LOCUS 010_IIG_Bs04_SNP 3867129 bp DNA circular UNA 12-JAN-2021 DEFINITION Bacillus subtilis strain Delta6 (hybrid trycycler assembly). ACCESSION urn.local...1d3-cvskbt3 VERSION urn.local...1d3-cvskbt3 KEYWORDS . SOURCE ORGANISM . FEATURES Location/Qualifiers S_feature complement(3867019..658) /Source="Nicolas_S_feature" /locus_tag="new_299_1067_c" /HighExp="S4, LoTm, S3, C30, S5, S7, S6, T5.0H, S8, M9-stat" /AntisenseName="dnaA" /AntisenseCor="-0.57810076860528403" /AntisenseRegPval="-24.7" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S4" CDS 1..1341 /gene="dnaA" /locus_tag="BSU_00010" /old_locus_tag="BSU00010" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:2167836, 2846289, 12682299, 16120674, 1779750, 28166228" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2167836, 2846289, 12682299, 16120674, 1779750, 28166228; Product type f : factor" /codon_start=1 /transl_table=11 /product="chromosomal replication initiator informational ATPase" /protein_id="NP_387882.1" /db_xref="EnsemblGenomes-Gn:BSU00010" /db_xref="EnsemblGenomes-Tr:CAB11777" /db_xref="GOA:P05648" /db_xref="InterPro:IPR001957" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR010921" /db_xref="InterPro:IPR013159" /db_xref="InterPro:IPR013317" /db_xref="InterPro:IPR018312" /db_xref="InterPro:IPR020591" /db_xref="InterPro:IPR024633" /db_xref="InterPro:IPR027417" /db_xref="PDB:4TPS" /db_xref="SubtiList:BG10065" /db_xref="UniProtKB/Swiss-Prot:P05648" /translation="MENILDLWNQALAQIEKKLSKPSFETWMKSTKAHSLQGDTLTIT APNEFARDWLESRYLHLIADTIYELTGEELSIKFVIPQNQDVEDFMPKPQVKKAVKED TSDFPQNMLNPKYTFDTFVIGSGNRFAHAASLAVAEAPAKAYNPLFIYGGVGLGKTHL MHAIGHYVIDHNPSAKVVYLSSEKFTNEFINSIRDNKAVDFRNRYRNVDVLLIDDIQF LAGKEQTQEEFFHTFNTLHEESKQIVISSDRPPKEIPTLEDRLRSRFEWGLITDITPP DLETRIAILRKKAKAEGLDIPNEVMLYIANQIDSNIRELEGALIRVVAYSSLINKDIN ADLAAEALKDIIPSSKPKVITIKEIQRVVGQQFNIKLEDFKAKKRTKSVAFPRQIAMY LSREMTDSSLPKIGEEFGGRDHTTVIHAHEKISKLLADDEQLQQHVKEIKEQLK*" /label="dnaA CDS" gene 1..1341 /gene="dnaA" /locus_tag="BSU_00010" /old_locus_tag="BSU00010" /label="dnaA gene" promotor_-10 complement(631..649) /Source="Nicolas_upshift_promotors" /id="U3" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1004 /SigmaFactorBS="ttcttcgtgtaatgtgttaaatgtatggaaaaattcttcctg ggtttGTTCTTtccccgctaaaaattGAATATCATCTATCAAAAGcacatcaacattt c" /listShort="S4, S2" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(657) /Source="Nicolas_upshifts" /id="U3" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1004 /SigmaFactorBS="ttcttcgtgtaatgtgttaaatgtatggaaaaattcttcctg ggtttGTTCTTtccccgctaaaaattGAATATCATCTATCAAAAGcacatcaacattt c" /listShort="S4, S2" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(665..670) /Source="Nicolas_upshift_promotors" /id="U3" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1004 /SigmaFactorBS="ttcttcgtgtaatgtgttaaatgtatggaaaaattcttcctg ggtttGTTCTTtccccgctaaaaattGAATATCATCTATCAAAAGcacatcaacattt c" /listShort="S4, S2" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1342..1529 /Source="Nicolas_S_feature" /locus_tag="new_1751_1938" /HighExp="G150, Heat, G180, G135, Paraq, Oxctl, dia0, LBGstat, S1, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S5" CDS 1530..2666 /gene="dnaN" /locus_tag="BSU_00020" /old_locus_tag="BSU00020" /EC_number="2.7.7.7" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:2846289, 11395445, 12682299, 20453097, 23228104, 28878042" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2846289, 11395445, 12682299, 20453097, 23228104, 28878042; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="DNA polymerase III (beta subunit)" /protein_id="NP_387883.1" /db_xref="EnsemblGenomes-Gn:BSU00020" /db_xref="EnsemblGenomes-Tr:CAB11778" /db_xref="GOA:P05649" /db_xref="InterPro:IPR001001" /db_xref="InterPro:IPR022634" /db_xref="InterPro:IPR022635" /db_xref="InterPro:IPR022637" /db_xref="PDB:4TR6" /db_xref="SubtiList:BG10066" /db_xref="UniProtKB/Swiss-Prot:P05649" /translation="MKFTIQKDRLVESVQDVLKAVSSRTTIPILTGIKIVASDDGVSF TGSDSDISIESFIPKEEGDKEIVTIEQPGSIVLQARFFSEIVKKLPMATVEIEVQNQY LTIIRSGKAEFNLNGLDADEYPHLPQIEEHHAIQIPTDLLKNLIRQTVFAVSTSETRP ILTGVNWKVEQSELLCTATDSHRLALRKAKLDIPEDRSYNVVIPGKSLTELSKILDDN QELVDIVITETQVLFKAKNVLFFSRLLDGNYPDTTSLIPQDSKTEIIVNTKEFLQAID RASLLAREGRNNVVKLSAKPAESIEISSNSPEIGKVVEAIVADQIEGEELNISFSPKY MLDALKVLEGAEIRVSFTGAMRPFLIRTPNDETIVQLILPVRTY*" /label="dnaN CDS" gene 1530..2666 /gene="dnaN" /locus_tag="BSU_00020" /old_locus_tag="BSU00020" /label="dnaN gene" downshifts 2650 /Source="Nicolas_upshifts" /id="D1" /incds=0 /nref=29 /ntot=161 /MaxReadThrough="5.22584" /MaxDrop="4.17087" /score="21.887269" /energy="-14.2" /TU="U1" /idTUdmin="U1" /TUdmin="-572" /isTUend="FALSE" /label="downshifts" promotor_-35 2731..2735 /Source="Nicolas_upshift_promotors" /id="U4" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.826173826173826" /psig="0.999000999001" /xcortree=2587 /SigmaFactorBS="ttctattcggtatctgctccgacaagttttcCCTTTccctaa ttcgttttttTTTAGTACAATTAGATATTAgtgatatttgaaagaggtcgatataatg g" /listShort="yaaA, recF, yaaB, gyrB, S6, gyrA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2752..2771 /Source="Nicolas_upshift_promotors" /id="U4" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.826173826173826" /psig="0.999000999001" /xcortree=2587 /SigmaFactorBS="ttctattcggtatctgctccgacaagttttcCCTTTccctaa ttcgttttttTTTAGTACAATTAGATATTAgtgatatttgaaagaggtcgatataatg g" /listShort="yaaA, recF, yaaB, gyrB, S6, gyrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2760 /Source="Nicolas_upshifts" /id="U4" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.826173826173826" /psig="0.999000999001" /xcortree=2587 /SigmaFactorBS="ttctattcggtatctgctccgacaagttttcCCTTTccctaa ttcgttttttTTTAGTACAATTAGATATTAgtgatatttgaaagaggtcgatataatg g" /listShort="yaaA, recF, yaaB, gyrB, S6, gyrA" /GFF_Attribute="listLong" /label="upshifts" CDS 2797..3012 /gene="rlbA" /locus_tag="BSU_00030" /old_locus_tag="BSU00030" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:24637032, 24939895" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 24637032, 24939895; Product type f: factor" /codon_start=1 /transl_table=11 /product="RNA binding protein involved in ribosome maturation" /protein_id="NP_387884.1" /db_xref="EnsemblGenomes-Gn:BSU00030" /db_xref="EnsemblGenomes-Tr:CAB11779" /db_xref="GOA:P05650" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR014330" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG10067" /db_xref="UniProtKB/Swiss-Prot:P05650" /translation="MANPISIDTEMITLGQFLKLADVIQSGGMAKWFLSEHEVLVNDE PDNRRGRKLYVGDVVEIEGFGSFQVVN*" /label="rlbA CDS" gene 2797..3012 /gene="rlbA" /locus_tag="BSU_00030" /old_locus_tag="BSU00030" /label="rlbA gene" CDS 3028..4140 /gene="recF" /locus_tag="BSU_00040" /old_locus_tag="BSU00040" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:15186413, 16061691, 16385024, 22342069" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15186413, 16061691, 16385024, 22342069; Product type f: factor" /codon_start=1 /transl_table=11 /product="RecA filament-DNA complex stabilisation, ssDNA and dsDNA binding, ATP binding" /protein_id="NP_387885.1" /db_xref="EnsemblGenomes-Gn:BSU00040" /db_xref="EnsemblGenomes-Tr:CAB11780" /db_xref="GOA:P05651" /db_xref="InterPro:IPR001238" /db_xref="InterPro:IPR003395" /db_xref="InterPro:IPR018078" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10068" /db_xref="UniProtKB/Swiss-Prot:P05651" /translation="MYIQNLELTSYRNYDHAELQFENKVNVIIGENAQGKTNLMEAIY VLSMAKSHRTSNDKELIRWDKDYAKIEGRVMKQNGAIPMQLVISKKGKKGKVNHIEQQ KLSQYVGALNTIMFAPEDLNLVKGSPQVRRRFLDMEIGQVSPVYLHDLSLYQKILSQR NHFLKQLQTRKQTDRTMLDVLTDQLVEVAAKVVVKRLQFTAQLEKWAQPIHAGISRGL EELTLKYHTALDVSDPLDLSKIGDSYQEAFSKLREKEIERGVTLSGPHRDDVLFYVNG RDVQTYGSQGQQRTTALSLKLAEIDLIHEEIGEYPILLLDDVLSELDDYRQSHLLHTI QGRVQTFVTTTSVDGIDHETLRQAGMFRVQNGALVK*" /label="recF CDS" gene 3028..4140 /gene="recF" /locus_tag="BSU_00040" /old_locus_tag="BSU00040" /label="recF gene" misc_feature 3226..3245 /Source="Nicolas_upshift_promotors" /id="U5" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2750 /SigmaFactorBS="cggacatcaaatgacaaagaacttatacggtgggacaaagac TATGCTAAAATAGAGGGAAGagtgatgaagcaaaacggggcgatcccgatgcagctcg t" /listShort="yaaB, gyrB, S6, gyrA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3244 /Source="Nicolas_upshifts" /id="U5" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2750 /SigmaFactorBS="cggacatcaaatgacaaagaacttatacggtgggacaaagac TATGCTAAAATAGAGGGAAGagtgatgaagcaaaacggggcgatcccgatgcagctcg t" /listShort="yaaB, gyrB, S6, gyrA" /GFF_Attribute="listLong" /label="upshifts" CDS 4158..4403 /gene="remB" /locus_tag="BSU_00050" /old_locus_tag="BSU00050" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:19363116" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19363116; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of extracellular matrix formation" /protein_id="NP_387886.2" /db_xref="EnsemblGenomes-Gn:BSU00050" /db_xref="EnsemblGenomes-Tr:CAB11781" /db_xref="InterPro:IPR007169" /db_xref="SubtiList:BG10069" /db_xref="UniProtKB/Swiss-Prot:P37525" /translation="MYIHLGDDFVVSTRDIVGIFDFKANMSPIVEEFLKKQKHKVVPS VNGTPKSIVVTVQNIYYSPLSSSTLKKRAQFMFEIDS*" /label="remB CDS" gene 4158..4403 /gene="remB" /locus_tag="BSU_00050" /old_locus_tag="BSU00050" /label="remB gene" CDS 4458..6374 /gene="gyrB" /locus_tag="BSU_00060" /old_locus_tag="BSU00060" /EC_number="5.99.1.3" /function="16.2: Construct biomass (Anabolism)" /function="16.9: Replicate" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12682299, 12767818, 17320901" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 12767818, 17320901; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA gyrase (subunit B)" /protein_id="NP_387887.1" /db_xref="EnsemblGenomes-Gn:BSU00060" /db_xref="EnsemblGenomes-Tr:CAB11782" /db_xref="GOA:P05652" /db_xref="InterPro:IPR001241" /db_xref="InterPro:IPR002288" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR006171" /db_xref="InterPro:IPR011557" /db_xref="InterPro:IPR013506" /db_xref="InterPro:IPR013759" /db_xref="InterPro:IPR013760" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR018522" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR034160" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG10070" /db_xref="UniProtKB/Swiss-Prot:P05652" /translation="MEQQQNSYDENQIQVLEGLEAVRKRPGMYIGSTNSKGLHHLVWE IVDNSIDEALAGYCTDINIQIEKDNSITVVDNGRGIPVGIHEKMGRPAVEVIMTVLHA GGKFDGSGYKVSGGLHGVGASVVNALSTELDVTVHRDGKIHRQTYKRGVPVTDLEIIG ETDHTGTTTHFVPDPEIFSETTEYDYDLLANRVRELAFLTKGVNITIEDKREGQERKN EYHYEGGIKSYVEYLNRSKEVVHEEPIYIEGEKDGITVEVALQYNDSYTSNIYSFTNN INTYEGGTHEAGFKTGLTRVINDYARKKGLIKENDPNLSGDDVREGLTAIISIKHPDP QFEGQTKTKLGNSEARTITDTLFSTAMETFMLENPDAAKKIVDKGLMAARARMAAKKA RELTRRKSALEISNLPGKLADCSSKDPSISELYIVEGDSAGGSAKQGRDRHFQAILPL RGKILNVEKARLDKILSNNEVRSMITALGTGIGEDFNLEKARYHKVVIMTDADVDGAH IRTLLLTFFYRYMRQIIENGYVYIAQPPLYKVQQGKRVEYAYNDKELEELLKTLPQTP KPGLQRYKGLGEMNATQLWETTMDPSSRTLLQVTLEDAMDADETFEMLMGDKVEPRRN FIEANARYVKNLDI*" /label="gyrB CDS" gene 4458..6374 /gene="gyrB" /locus_tag="BSU_00060" /old_locus_tag="BSU00060" /label="gyrB gene" promotor_-10 complement(6003..6021) /Source="Nicolas_upshift_promotors" /id="U6" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1200 /SigmaFactorBS="cggcggctgcgcaatgtacacgtAGCCATtttcgataatttg gcGCATATATCTGTAAAAGAAcgttaacagcagtgttctgatgtgcgcgccgtcaaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(6005) /Source="Nicolas_upshifts" /id="U6" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1200 /SigmaFactorBS="cggcggctgcgcaatgtacacgtAGCCATtttcgataatttg gcGCATATATCTGTAAAAGAAcgttaacagcagtgttctgatgtgcgcgccgtcaaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(6037..6042) /Source="Nicolas_upshift_promotors" /id="U6" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1200 /SigmaFactorBS="cggcggctgcgcaatgtacacgtAGCCATtttcgataatttg gcGCATATATCTGTAAAAGAAcgttaacagcagtgttctgatgtgcgcgccgtcaaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 6375..6584 /Source="Nicolas_S_feature" /locus_tag="new_6784_6993" /HighExp="Cold, H2O2, G180, Oxctl, G135, G150, Sw, dia15, LBGexp, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="SigA" /TUlongPSig=1 /label="S6" CDS 6585..9050 /gene="gyrA" /locus_tag="BSU_00070" /old_locus_tag="BSU00070" /EC_number="5.99.1.3" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:12682299, 12767818, 17320901, 27557712" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 12767818, 17320901, 27557712; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA gyrase (subunit A)" /protein_id="NP_387888.1" /db_xref="EnsemblGenomes-Gn:BSU00070" /db_xref="EnsemblGenomes-Tr:CAB11783" /db_xref="GOA:P05653" /db_xref="InterPro:IPR002205" /db_xref="InterPro:IPR005743" /db_xref="InterPro:IPR006691" /db_xref="InterPro:IPR013757" /db_xref="InterPro:IPR013758" /db_xref="InterPro:IPR013760" /db_xref="InterPro:IPR024946" /db_xref="InterPro:IPR035516" /db_xref="PDB:4DDQ" /db_xref="SubtiList:BG10071" /db_xref="UniProtKB/Swiss-Prot:P05653" /translation="MSEQNTPQVREINISQEMRTSFLDYAMSVIVSRALPDVRDGLKP VHRRILYAMNDLGMTSDKPYKKSARIVGEVIGKYHPHGDSAVYESMVRMAQDFNYRYM LVDGHGNFGSVDGDSAAAMRYTEARMSKISMEILRDITKDTIDYQDNYDGSEREPVVM PSRFPNLLVNGAAGIAVGMATNIPPHQLGEIIDGVLAVSENPDITIPELMEVIPGPDF PTAGQILGRSGIRKAYESGRGSITIRAKAEIEQTSSGKERIIVTELPYQVNKAKLIEK IADLVRDKKIEGITDLRDESDRTGMRIVIEIRRDANANVILNNLYKQTALQTSFGINL LALVDGQPKVLTLKQCLEHYLDHQKVVIRRRTAYELRKAEARAHILEGLRVALDHLDA VISLIRNSQTAEIARTGLIEQFSLTEKQAQAILDMRLQRLTGLEREKIEEEYQSLVKL IAELKDILANEYKVLEIIREELTEIKERFNDERRTEIVTSGLETIEDEDLIERENIVV TLTHNGYVKRLPASTYRSQKRGGKGVQGMGTNEDDFVEHLISTSTHDTILFFSNKGKV YRAKGYEIPEYGRTAKGIPIINLLEVEKGEWINAIIPVTEFNAELYLFFTTKHGVSKR TSLSQFANIRNNGLIALSLREDDELMGVRLTDGTKQIIIGTKNGLLIRFPETDVREMG RTAAGVKGITLTDDDVVVGMEILEEESHVLIVTEKGYGKRTPAEEYRTQSRGGKGLKT AKITENNGQLVAVKATKGEEDLMIITASGVLIRMDINDISITGRVTQGVRLIRMAEEE HVATVALVEKNEEDENEEEQEEV*" /label="gyrA CDS" gene 6585..9050 /gene="gyrA" /locus_tag="BSU_00070" /old_locus_tag="BSU00070" /label="gyrA gene" promotor_-35 8964..8967 /Source="Nicolas_upshift_promotors" /id="U7" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.418581418581419" /psig="0.9000999000999" /xcortree=2642 /SigmaFactorBS="tggacatcaatgatatctccatcaccggacgtgtcactcaag gtgtgcgtctcatcagaATGGcagaagaagagcatgtTGCTACAGTAGCTTTAGTtga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 8965 /Source="Nicolas_upshifts" /id="U7" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.418581418581419" /psig="0.9000999000999" /xcortree=2642 /SigmaFactorBS="tggacatcaatgatatctccatcaccggacgtgtcactcaag gtgtgcgtctcatcagaATGGcagaagaagagcatgtTGCTACAGTAGCTTTAGTtga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 8984..9001 /Source="Nicolas_upshift_promotors" /id="U7" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.418581418581419" /psig="0.9000999000999" /xcortree=2642 /SigmaFactorBS="tggacatcaatgatatctccatcaccggacgtgtcactcaag gtgtgcgtctcatcagaATGGcagaagaagagcatgtTGCTACAGTAGCTTTAGTtga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 9031 /Source="Nicolas_upshifts" /id="D2" /incds=0 /nref=251 /ntot=261 /MaxReadThrough="3.73971" /MaxDrop="8.1288" /score="33.5021066" /energy="-14.1" /TU="NA" /idTUdmin="U4" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 9095..9101 /Source="Nicolas_upshift_promotors" /id="U8" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2622 /SigmaFactorBS="cagctgaaatagctgcgcttttttgtgtcataaccCTTTACA gtcataaaaattaTGGTATAATCATTTCTGTTGtctttttaaagacacaagcatgacc a" /listShort="S7, rrnO-16S" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 9115..9134 /Source="Nicolas_upshift_promotors" /id="U8" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2622 /SigmaFactorBS="cagctgaaatagctgcgcttttttgtgtcataaccCTTTACA gtcataaaaattaTGGTATAATCATTTCTGTTGtctttttaaagacacaagcatgacc a" /listShort="S7, rrnO-16S" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 9120..9205 /Source="Nicolas_S_feature" /locus_tag="new_9529_9614" /HighExp="LBGstat, H2O2, Paraq, Oxctl, UNK1, LBGexp, LPhT, MG-0.2, MG 25, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S7" upshifts 9120 /Source="Nicolas_upshifts" /id="U8" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2622 /SigmaFactorBS="cagctgaaatagctgcgcttttttgtgtcataaccCTTTACA gtcataaaaattaTGGTATAATCATTTCTGTTGtctttttaaagacacaagcatgacc a" /listShort="S7, rrnO-16S" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 9191..9198 /Source="Nicolas_upshift_promotors" /id="U9" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.889110889110889" /psig=1 /xcortree=2634 /SigmaFactorBS="cacaagcatgaccattatgactagtaaaaactttttcaaaaa agTATTGACCtagttaactaaaaaTGTTACTATTAAGTAGTCGCtttgagagaagcac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 9207 /Source="Nicolas_upshifts" /id="U9" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.889110889110889" /psig=1 /xcortree=2634 /SigmaFactorBS="cacaagcatgaccattatgactagtaaaaactttttcaaaaa agTATTGACCtagttaactaaaaaTGTTACTATTAAGTAGTCGCtttgagagaagcac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 9213..9232 /Source="Nicolas_upshift_promotors" /id="U9" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.889110889110889" /psig=1 /xcortree=2634 /SigmaFactorBS="cacaagcatgaccattatgactagtaaaaactttttcaaaaa agTATTGACCtagttaactaaaaaTGTTACTATTAAGTAGTCGCtttgagagaagcac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" rRNA 9401..10955 /gene="rrnO-16S" /locus_tag="BSU_rRNA_1" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnO-16S rRNA" gene 9401..10955 /gene="rrnO-16S" /locus_tag="BSU_rRNA_1" /label="rrnO-16S gene" tRNA 11055..11131 /gene="trnO-Ile" /locus_tag="BSU_tRNA_5" /product="tRNA-Ile" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnO-Ile tRNA" gene 11055..11131 /gene="trnO-Ile" /locus_tag="BSU_tRNA_5" /label="trnO-Ile gene" tRNA 11143..11218 /gene="trnO-Ala" /locus_tag="BSU_tRNA_6" /product="tRNA-Ala" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ala(UGC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnO-Ala tRNA" gene 11143..11218 /gene="trnO-Ala" /locus_tag="BSU_tRNA_6" /label="trnO-Ala gene" rRNA 11300..14227 /gene="rrnO-23S" /locus_tag="BSU_rRNA_2" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnO-23S rRNA" gene 11300..14227 /gene="rrnO-23S" /locus_tag="BSU_rRNA_2" /label="rrnO-23S gene" rRNA 14283..14401 /gene="rrnO-5S" /locus_tag="BSU_rRNA_3" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnO-5S rRNA" gene 14283..14401 /gene="rrnO-5S" /locus_tag="BSU_rRNA_3" /label="rrnO-5S gene" S_feature 14402..15459 /Source="Nicolas_S_feature" /locus_tag="new_14811_15868" /HighExp="G180, T0.0H, T0.30H, G135, T-0.40H, LBGstat, Cold, Paraq, C30, Oxctl" /AntisenseName="yaaC" /AntisenseCor="-4.5985764709218099E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S8" CDS complement(14438..15385) /gene="yaaC" /locus_tag="BSU_00080" /old_locus_tag="BSU00080" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22333191" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_387889.1" /db_xref="EnsemblGenomes-Gn:BSU00080" /db_xref="EnsemblGenomes-Tr:CAB11784" /db_xref="InterPro:IPR026988" /db_xref="SubtiList:BG10072" /db_xref="UniProtKB/Swiss-Prot:P37526" /translation="MTYHEWKDLALFYSVESTQKFLEKVYILNGINDAKKNSFKNSER FIYFLKHAESFYKQAAYSPLEIKPILLFYGMAQLIKACLITRDPHYPSHTSVLAHGVT TRKRKKQNYCFSDDEVKIQRNGLCVHFMKHLFGQSDIVDERYTMKKLLMAIPELSDIF YFQQKERFMTKVEKDKNEIFVPEEVVINYKMSDSRFAEYMSHHYQWSFTKKNEHGLLF EISPQDKEPWTSTSLLFDMEKNQYYIPSQREQFLRLPEMTIHYLILYNVGMIARYETE WWYELLTQHISDDYVLIQQFLLVSEKKFPKYASQFLLHF*" /label="yaaC CDS" gene complement(14438..15385) /gene="yaaC" /locus_tag="BSU_00080" /old_locus_tag="BSU00080" /label="yaaC gene" promotor_-35 15438..15445 /Source="Nicolas_upshift_promotors" /id="U10" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.721278721278721" /psig=1 /xcortree=2668 /SigmaFactorBS="ctttccgttatctaaatatttcaactctttcccgcttCCTTG ACAtgctcttggctagtTGATAATCTACATATAATATtttgccgaaaagagggggatt t" /listShort="guaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 15460..15479 /Source="Nicolas_upshift_promotors" /id="U10" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.721278721278721" /psig=1 /xcortree=2668 /SigmaFactorBS="ctttccgttatctaaatatttcaactctttcccgcttCCTTG ACAtgctcttggctagtTGATAATCTACATATAATATtttgccgaaaagagggggatt t" /listShort="guaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 15461 /Source="Nicolas_upshifts" /id="U10" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.721278721278721" /psig=1 /xcortree=2668 /SigmaFactorBS="ctttccgttatctaaatatttcaactctttcccgcttCCTTG ACAtgctcttggctagtTGATAATCTACATATAATATtttgccgaaaagagggggatt t" /listShort="guaB" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(15466) /Source="Nicolas_upshifts" /id="U11" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.89010989010989" /psig="0.89010989010989" /xcortree=947 /SigmaFactorBS="tgaaaatttactttcccacaTTAGTAAatccccctcttttCG GCAAAATATTatatgtagattatcaactagccaagagcatgtcaaggaagcgggaaag a" /listShort="yaaC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(15475..15486) /Source="Nicolas_upshift_promotors" /id="U11" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.89010989010989" /psig="0.89010989010989" /xcortree=947 /SigmaFactorBS="tgaaaatttactttcccacaTTAGTAAatccccctcttttCG GCAAAATATTatatgtagattatcaactagccaagagcatgtcaaggaagcgggaaag a" /listShort="yaaC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(15500..15506) /Source="Nicolas_upshift_promotors" /id="U11" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.89010989010989" /psig="0.89010989010989" /xcortree=947 /SigmaFactorBS="tgaaaatttactttcccacaTTAGTAAatccccctcttttCG GCAAAATATTatatgtagattatcaactagccaagagcatgtcaaggaagcgggaaag a" /listShort="yaaC" /GFF_Attribute="listLong" /label="promotor_-35" CDS 15506..16972 /gene="guaB" /locus_tag="BSU_00090" /old_locus_tag="BSU00090" /EC_number="1.1.1.205" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 1722815, 17611193, 1979163, 3125411, 8917437" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 1722815, 17611193, 1979163, 3125411, 8917437; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="inosine-monophosphate dehydrogenase" /protein_id="NP_387890.1" /db_xref="EnsemblGenomes-Gn:BSU00090" /db_xref="EnsemblGenomes-Tr:CAB11785" /db_xref="GOA:P21879" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR001093" /db_xref="InterPro:IPR005990" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR015875" /db_xref="SubtiList:BG10073" /db_xref="UniProtKB/Swiss-Prot:P21879" /translation="MWESKFSKEGLTFDDVLLVPAKSEVLPRDVDLSVELTKTLKLNI PVISAGMDTVTESAMAIAMARQGGLGIIHKNMSIEQQAEQVDKVKRSERGVITNPFFL TPDHQVFDAEHLMGKYRISGVPIVNNEEDQKLVGIITNRDLRFISDYSMKISDVMTKE ELVTASVGTTLDEAEKILQKHKIEKLPLVDDQNKLKGLITIKDIEKVIEFPNSSKDIH GRLIVGAAVGVTGDTMTRVKKLVEANVDVIVIDTAHGHSQGVLNTVTKIRETYPELNI IAGNVATAEATRALIEAGADVVKVGIGPGSICTTRVVAGVGVPQITAIYDCATEARKH GKTIIADGGIKFSGDITKALAAGGHAVMLGSLLAGTSESPGETEIYQGRRFKVYRGMG SVAAMEKGSKDRYFQEENKKFVPEGIEGRTPYKGPVEETVYQLVGGLRSGMGYCGSKD LRALREEAQFIRMTGAGLRESHPHDVQITKESPNYTIS*" /label="guaB CDS" gene 15506..16972 /gene="guaB" /locus_tag="BSU_00090" /old_locus_tag="BSU00090" /label="guaB gene" downshifts complement(15510) /Source="Nicolas_upshifts" /id="D3" /incds=0 /nref=33 /ntot=102 /MaxReadThrough="1.81989" /MaxDrop="4.44626" /score="-6.76739893" /energy="-12.2" /TU="NA" /idTUdmin="U12" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_no_box complement(15536..15636) /Source="Nicolas_upshift_promotors" /id="U12" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.922077922077922" /psig="0.016983016983017" /xcortree=82 /SigmaFactorBS="atatttagctttaacgtttttgtaagttctacagataaatcc acatcacgcggaagtacctcagactttgctggtacaagcagcacatcgtcgaacgtta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(15576) /Source="Nicolas_upshifts" /id="U12" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.922077922077922" /psig="0.016983016983017" /xcortree=82 /SigmaFactorBS="atatttagctttaacgtttttgtaagttctacagataaatcc acatcacgcggaagtacctcagactttgctggtacaagcagcacatcgtcgaacgtta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(16829..17424) /Source="Nicolas_S_feature" /locus_tag="new_17238_17833_c" /HighExp="Etha, Gly, C30, Salt, S8, S6, HiTm, S7, Sw, C90" /AntisenseName="dacA" /AntisenseCor="-0.39306815699287101" /AntisenseRegPval="-10.6" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S9" downshifts 16960 /Source="Nicolas_upshifts" /id="D4" /incds=0 /nref=243 /ntot=277 /MaxReadThrough="3.34899" /MaxDrop="7.78161" /score="26.7620012" /energy="-10.6" /TU="NA" /idTUdmin="U10" /TUdmin="-14" /isTUend="TRUE" /label="downshifts" promotor_-35 17018..17022 /Source="Nicolas_upshift_promotors" /id="U13" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.948051948051948" /psig=1 /xcortree=2602 /SigmaFactorBS="aaattaaaaacatttgacagggtctctgactctgTCTATttt ttttatactgatTATGATAAAATTTATACTGTtgtgcattgaaaatgtccttaacggc t" /listShort="S10, dacA, S11, S12, pdxS, pdxT, NA, serS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 17038..17057 /Source="Nicolas_upshift_promotors" /id="U13" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.948051948051948" /psig=1 /xcortree=2602 /SigmaFactorBS="aaattaaaaacatttgacagggtctctgactctgTCTATttt ttttatactgatTATGATAAAATTTATACTGTtgtgcattgaaaatgtccttaacggc t" /listShort="S10, dacA, S11, S12, pdxS, pdxT, NA, serS" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 17044..17124 /Source="Nicolas_S_feature" /locus_tag="new_17453_17533" /HighExp="C30, LBGstat, G180, G150, LBGexp, G135, Lbexp, Oxctl, dia0, MG 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S10" upshifts 17044 /Source="Nicolas_upshifts" /id="U13" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.948051948051948" /psig=1 /xcortree=2602 /SigmaFactorBS="aaattaaaaacatttgacagggtctctgactctgTCTATttt ttttatactgatTATGATAAAATTTATACTGTtgtgcattgaaaatgtccttaacggc t" /listShort="S10, dacA, S11, S12, pdxS, pdxT, NA, serS" /GFF_Attribute="listLong" /label="upshifts" CDS 17125..18456 /gene="dacA" /locus_tag="BSU_00100" /old_locus_tag="BSU00100" /EC_number="3.4.16.4" /experiment="publication(s) with functional evidences, PMID:8370539, 9864321, 10383963, 21378199" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8370539, 9864321, 10383963, 21378199; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 5)" /protein_id="NP_387891.1" /db_xref="EnsemblGenomes-Gn:BSU00100" /db_xref="EnsemblGenomes-Tr:CAB11786" /db_xref="GOA:P08750" /db_xref="InterPro:IPR001967" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR012907" /db_xref="InterPro:IPR015956" /db_xref="InterPro:IPR018044" /db_xref="InterPro:IPR037167" /db_xref="SubtiList:BG10074" /db_xref="UniProtKB/Swiss-Prot:P08750" /translation="MNIKKCKQLLMSLVVLTLAVTCLAPMSKAKAASDPIDINASAAI MIEASSGKILYSKNADKRLPIASMTKMMTEYLLLEAIDQGKVKWDQTYTPDDYVYEIS QDNSLSNVPLRKDGKYTVKELYQATAIYSANAAAIAIAEIVAGSETKFVEKMNAKAKE LGLTDYKFVNATGLENKDLHGHQPEGTSVNEESEVSAKDMAVLADHLITDYPEILETS SIAKTKFREGTDDEMDMPNWNFMLKGLVSEYKKATVDGLKTGSTDSAGSCFTGTAERN GMRVITVVLNAKGNLHTGRFDETKKMFDYAFDNFSMKEIYAEGDQVKGHKTISVDKGK EKEVGIVTNKAFSLPVKNGEEKNYKAKVTLNKDNLTAPVKKGTKVGKLTAEYTGDEKD YGFLNSDLAGVDLVTKENVEKANWFVLTMRSIGGFFAGIWGSIVDTVTGWF*" /label="dacA CDS" gene 17125..18456 /gene="dacA" /locus_tag="BSU_00100" /old_locus_tag="BSU00100" /label="dacA gene" promotor_-10 complement(17413..17431) /Source="Nicolas_upshift_promotors" /id="U14" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=212 /SigmaFactorBS="tactgtgtatttcccgtctttccgaagaggaaCGTTTGAtaa gctgttatcttGGGAAATTTCATACACATAgtcatcaggcgtataggtttggtcccat t" /listShort="S9" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(17424) /Source="Nicolas_upshifts" /id="U14" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=212 /SigmaFactorBS="tactgtgtatttcccgtctttccgaagaggaaCGTTTGAtaa gctgttatcttGGGAAATTTCATACACATAgtcatcaggcgtataggtttggtcccat t" /listShort="S9" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(17446..17452) /Source="Nicolas_upshift_promotors" /id="U14" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=212 /SigmaFactorBS="tactgtgtatttcccgtctttccgaagaggaaCGTTTGAtaa gctgttatcttGGGAAATTTCATACACATAgtcatcaggcgtataggtttggtcccat t" /listShort="S9" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 18338 /Source="Nicolas_upshifts" /id="D5" /incds=1 /nref=1 /ntot=20 /MaxReadThrough="6.76335" /MaxDrop="2.1925" /score="26.7620012" /energy="-10.6" /TU="U13" /idTUdmin="U10" /TUdmin=1364 /isTUend="FALSE" /label="downshifts" S_feature 18457..18565 /Source="Nicolas_S_feature" /locus_tag="new_18866_18974" /HighExp="C30, MG 15, MG 10, MG-0.1, MG 25, BMM, ferm, Cold, MG 60, MG-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S11" promotor_-35 18535..18538 /Source="Nicolas_upshift_promotors" /id="U15" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.61038961038961" /psig="0.998001998001998" /xcortree=2311 /SigmaFactorBS="gaaaaaacccaatttttaataaaaaatgATTTtcaaagcgct aaaaACCGAATAAAATAGTATATAtgcatatgaattattggatttctaggatacaata a" /listShort="S12, pdxS, pdxT, NA, serS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 18553..18572 /Source="Nicolas_upshift_promotors" /id="U15" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.61038961038961" /psig="0.998001998001998" /xcortree=2311 /SigmaFactorBS="gaaaaaacccaatttttaataaaaaatgATTTtcaaagcgct aaaaACCGAATAAAATAGTATATAtgcatatgaattattggatttctaggatacaata a" /listShort="S12, pdxS, pdxT, NA, serS" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 18567..18652 /Source="Nicolas_S_feature" /locus_tag="new_18976_19061" /HighExp="BMM, MG 25, SMM, MG 15, UNK1, MG 10, GM 150, MG-0.1, MG 150, MG 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S12" upshifts 18567 /Source="Nicolas_upshifts" /id="U15" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.61038961038961" /psig="0.998001998001998" /xcortree=2311 /SigmaFactorBS="gaaaaaacccaatttttaataaaaaatgATTTtcaaagcgct aaaaACCGAATAAAATAGTATATAtgcatatgaattattggatttctaggatacaata a" /listShort="S12, pdxS, pdxT, NA, serS" /GFF_Attribute="listLong" /label="upshifts" CDS 18653..19537 /gene="pdxS" /locus_tag="BSU_00110" /old_locus_tag="BSU00110" /EC_number="4.3.3.6" /EC_number="4.-.-.-" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:14762015, 15771487, 15911615, 16157873, 17144654" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14762015, 15771487, 15911615, 16157873, 17144654; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamine amidotransferase for pyridoxal phosphate synthesis; pyridoxal 5'-phosphate synthase complex, synthase subunit" /protein_id="NP_387892.1" /db_xref="EnsemblGenomes-Gn:BSU00110" /db_xref="EnsemblGenomes-Tr:CAB11787" /db_xref="GOA:P37527" /db_xref="InterPro:IPR001852" /db_xref="InterPro:IPR011060" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR033755" /db_xref="PDB:2NV1" /db_xref="PDB:2NV2" /db_xref="SubtiList:BG10075" /db_xref="UniProtKB/Swiss-Prot:P37527" /translation="MAQTGTERVKRGMAEMQKGGVIMDVINAEQAKIAEEAGAVAVMA LERVPADIRAAGGVARMADPTIVEEVMNAVSIPVMAKARIGHIVEARVLEAMGVDYID ESEVLTPADEEFHLNKNEYTVPFVCGCRDLGEATRRIAEGASMLRTKGEPGTGNIVEA VRHMRKVNAQVRKVVAMSEDELMTEAKNLGAPYELLLQIKKDGKLPVVNFAAGGVATP ADAALMMQLGADGVFVGSGIFKSDNPAKFAKAIVEATTHFTDYKLIAELSKELGTAMK GIEISNLLPEQRMQERGW*" /label="pdxS CDS" gene 18653..19537 /gene="pdxS" /locus_tag="BSU_00110" /old_locus_tag="BSU00110" /label="pdxS gene" S_feature complement(18785..19514) /Source="Nicolas_S_feature" /locus_tag="new_19194_19923_c" /HighExp="S6, S8, S7, S5, S4, C30, S3, BT, C90, Gly" /AntisenseName="pdxS" /AntisenseCor="-0.65390240445415004" /AntisenseRegPval="-33.5" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S13" promotor_-10 complement(19502..19520) /Source="Nicolas_upshift_promotors" /id="U16" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1195 /SigmaFactorBS="cacctattgttaacatgtcagcagcgctcctatGTTCTTacc agccgcgttcttGCATACGCTGTTCTGGAAGtaagtttgagatttcaatccctttcat t" /listShort="S13" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(19514) /Source="Nicolas_upshifts" /id="U16" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1195 /SigmaFactorBS="cacctattgttaacatgtcagcagcgctcctatGTTCTTacc agccgcgttcttGCATACGCTGTTCTGGAAGtaagtttgagatttcaatccctttcat t" /listShort="S13" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(19536..19541) /Source="Nicolas_upshift_promotors" /id="U16" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1195 /SigmaFactorBS="cacctattgttaacatgtcagcagcgctcctatGTTCTTacc agccgcgttcttGCATACGCTGTTCTGGAAGtaagtttgagatttcaatccctttcat t" /listShort="S13" /GFF_Attribute="listLong" /label="promotor_-35" CDS 19559..20149 /gene="pdxT" /locus_tag="BSU_00120" /old_locus_tag="BSU00120" /EC_number="3.5.1.2" /EC_number="4.3.3.6" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:14585832, 14762015, 15771487, 17144654, 18271580, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14585832, 14762015, 15771487, 17144654, 18271580, 26735940; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="glutamine amidotransferase for pyridoxal phosphate synthesis; pyridoxal 5'-phosphate synthase complex, glutamine amidotransferase subunit PdxT" /protein_id="NP_387893.1" /db_xref="EnsemblGenomes-Gn:BSU00120" /db_xref="EnsemblGenomes-Tr:CAB11788" /db_xref="GOA:P37528" /db_xref="InterPro:IPR002161" /db_xref="InterPro:IPR021196" /db_xref="InterPro:IPR029062" /db_xref="PDB:1R9G" /db_xref="PDB:2NV0" /db_xref="PDB:2NV2" /db_xref="SubtiList:BG10076" /db_xref="UniProtKB/Swiss-Prot:P37528" /translation="MLTIGVLGLQGAVREHIHAIEACGAAGLVVKRPEQLNEVDGLIL PGGESTTMRRLIDTYQFMEPLREFAAQGKPMFGTCAGLIILAKEIAGSDNPHLGLLNV VVERNSFGRQVDSFEADLTIKGLDEPFTGVFIRAPHILEAGENVEVLSEHNGRIVAAK QGQFLGCSFHPELTEDHRVTQLFVEMVEEYKQKALV*" /label="pdxT CDS" gene 19559..20149 /gene="pdxT" /locus_tag="BSU_00120" /old_locus_tag="BSU00120" /label="pdxT gene" misc_RNA 20202..20414 /gene="tboS" /locus_tag="BSU_misc_RNA_1" /product="T-box riboswitch specific of serine tRNA ligase" /experiment="publication(s) with functional evidences, PMID:1317842, 9098041, 12165569, 12547201" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1317842, 9098041, 12165569, 12547201; Product type n: RNA" /function="16.3: Control" /label="tboS RNA" gene 20202..20414 /gene="tboS" /locus_tag="BSU_misc_RNA_1" /label="tboS gene" downshifts 20379 /Source="Nicolas_upshifts" /id="D6" /incds=0 /nref=9 /ntot=80 /MaxReadThrough="7.14793" /MaxDrop="4.37654" /score="41.1243331" /energy="-23.3" /TU="U13,U15" /idTUdmin="U13" /TUdmin="-1347" /isTUend="FALSE" /label="downshifts" CDS 20471..21748 /gene="serS" /locus_tag="BSU_00130" /old_locus_tag="BSU00130" /EC_number="6.1.1.11" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10546897, 12682299, 14732487" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10546897, 12682299, 14732487; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="seryl-tRNA synthetase" /protein_id="NP_387894.1" /db_xref="EnsemblGenomes-Gn:BSU00130" /db_xref="EnsemblGenomes-Tr:CAB11789" /db_xref="GOA:P37464" /db_xref="InterPro:IPR002314" /db_xref="InterPro:IPR002317" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR010978" /db_xref="InterPro:IPR015866" /db_xref="InterPro:IPR033729" /db_xref="SubtiList:BG10077" /db_xref="UniProtKB/Swiss-Prot:P37464" /translation="MLDTKMLRANFQEIKAKLVHKGEDLTDFDKFEALDDRRRELIGK VEELKGKRNEVSQQVAVLKREKKDADHIIKEMREVGEEIKKLDEELRTVEAELDTILL SIPNIPHESVPVGETEDDNVEVRKWGEKPSFAYEPKPHWDIADELGILDFERAAKVTG SRFVFYKGLGARLERALYNFMLDLHVDEYNYTEVIPPYMVNRASMTGTGQLPKFEEDA FKIREEDYFLIPTAEVPITNMHRDEILSGDSLPINYAAFSACFRSEAGSAGRDTRGLI RQHQFNKVELVKFVKPEDSYEELEKLTNQAERVLQLLELPYRVMSMCTGDLGFTAAKK YDIEVWIPSQDTYREISSCSNFEAFQARRANIRFRREAKGKPEHVHTLNGSGLAVGRT VAAILENYQQEDGSVVIPKVLRPYMGNREVMKP*" /label="serS CDS" gene 20471..21748 /gene="serS" /locus_tag="BSU_00130" /old_locus_tag="BSU00130" /label="serS gene" downshifts 21726 /Source="Nicolas_upshifts" /id="D7" /incds=0 /nref=234 /ntot=255 /MaxReadThrough="0.83411" /MaxDrop="7.38039" /score="17.6549558" /energy="-13.3" /TU="NA" /idTUdmin="U13" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 21837..21844 /Source="Nicolas_upshift_promotors" /id="U17" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.861138861138861" /psig=1 /xcortree=2413 /SigmaFactorBS="cggcattttcataaaaacaaaaaaagtttttaaaaatgCTTG ACCAcacgagaacatacgTGATATAGTTAGTCTTGTCGatacggaggaatacccaagt c" /listShort="trnSL-Ser1, S14, S15" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 21859..21878 /Source="Nicolas_upshift_promotors" /id="U17" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.861138861138861" /psig=1 /xcortree=2413 /SigmaFactorBS="cggcattttcataaaaacaaaaaaagtttttaaaaatgCTTG ACCAcacgagaacatacgTGATATAGTTAGTCTTGTCGatacggaggaatacccaagt c" /listShort="trnSL-Ser1, S14, S15" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 21859 /Source="Nicolas_upshifts" /id="U17" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.861138861138861" /psig=1 /xcortree=2413 /SigmaFactorBS="cggcattttcataaaaacaaaaaaagtttttaaaaatgCTTG ACCAcacgagaacatacgTGATATAGTTAGTCTTGTCGatacggaggaatacccaagt c" /listShort="trnSL-Ser1, S14, S15" /GFF_Attribute="listLong" /label="upshifts" tRNA 21883..21975 /gene="trnSL-Ser1" /locus_tag="BSU_tRNA_7" /product="tRNA-Ser" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ser(UGA); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Ser1 tRNA" gene 21883..21975 /gene="trnSL-Ser1" /locus_tag="BSU_tRNA_7" /label="trnSL-Ser1 gene" downshifts 21998 /Source="Nicolas_upshifts" /id="D8" /incds=0 /nref=168 /ntot=196 /MaxReadThrough="5.02201" /MaxDrop="8.36635" /score="29.7083093" /energy="-12.4" /TU="U17" /idTUdmin="U13" /TUdmin=272 /isTUend="FALSE" /label="downshifts" S_feature 22043..22120 /Source="Nicolas_S_feature" /locus_tag="new_22452_22529" /HighExp="Cold, H2O2, G180, Paraq, Oxctl, C30, G150, G135, BMM, Heat" /AntisenseName="dck" /AntisenseCor="0.61769771609764101" /AntisenseRegPval="-29" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S14" CDS complement(22087..22740) /gene="dck" /locus_tag="BSU_00140" /old_locus_tag="BSU00140" /EC_number="2.7.1.76" /EC_number="2.7.1.74" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:6251049, 11078735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6251049, 11078735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="deoxyadenosine/deoxycytidine kinase" /protein_id="NP_387895.1" /db_xref="EnsemblGenomes-Gn:BSU00140" /db_xref="EnsemblGenomes-Tr:CAB11790" /db_xref="GOA:P37529" /db_xref="InterPro:IPR002624" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031314" /db_xref="SubtiList:BG10078" /db_xref="UniProtKB/Swiss-Prot:P37529" /translation="MKEHHIPKNSIITVAGTVGVGKSTLTKTLAKRLGFKTSLEEVDH NPYLEKFYHDFERWSFHLQIYFLAERFKEQKTIFEAGGGFVQDRSIYEDTGIFAKMHA DKGTMSKVDYKTYTSLFEAMVMTPYFPHPDVLIYLEGDLENILNRIEQRGREMELQTS RSYWEEMHTRYENWISGFNACPVLKLRIEDYDLLNDENSIENIVDQIASVIHDNQKK* " /label="dck CDS" gene complement(22087..22740) /gene="dck" /locus_tag="BSU_00140" /old_locus_tag="BSU00140" /label="dck gene" promotor_-35 22106..22112 /Source="Nicolas_upshift_promotors" /id="U18" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.474525474525474" /psig="0.474525474525474" /xcortree=1189 /SigmaFactorBS="agaaaaagtgaatctcgactgagattcactttttttgattat caTGAATAActgaagcaatttgATCTACAATATTttcaatcgagttttcgtcgttcag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(22111) /Source="Nicolas_upshifts" /id="D9" /incds=0 /nref=88 /ntot=213 /MaxReadThrough="1.96668" /MaxDrop="4.49235" /score="14.5948578" /energy="-11" /TU="NA" /idTUdmin="U19" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" S_feature 22122..22758 /Source="Nicolas_S_feature" /locus_tag="new_22531_23167" /HighExp="G180, G135, Cold, C30, Paraq, H2O2, Oxctl, G150, S5, S6" /AntisenseName="dck" /AntisenseCor="0.15155468296621499" /AntisenseRegPval="-1.9" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S15" upshifts 22122 /Source="Nicolas_upshifts" /id="U18" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.474525474525474" /psig="0.474525474525474" /xcortree=1189 /SigmaFactorBS="agaaaaagtgaatctcgactgagattcactttttttgattat caTGAATAActgaagcaatttgATCTACAATATTttcaatcgagttttcgtcgttcag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 22126..22137 /Source="Nicolas_upshift_promotors" /id="U18" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.474525474525474" /psig="0.474525474525474" /xcortree=1189 /SigmaFactorBS="agaaaaagtgaatctcgactgagattcactttttttgattat caTGAATAActgaagcaatttgATCTACAATATTttcaatcgagttttcgtcgttcag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(22737..23360) /gene="dgk" /locus_tag="BSU_00150" /old_locus_tag="BSU00150" /EC_number="2.7.1.113" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11078735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11078735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="deoxyguanosine kinase" /protein_id="NP_387896.1" /db_xref="EnsemblGenomes-Gn:BSU00150" /db_xref="EnsemblGenomes-Tr:CAB11791" /db_xref="GOA:P37530" /db_xref="InterPro:IPR002624" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031314" /db_xref="SubtiList:BG10079" /db_xref="UniProtKB/Swiss-Prot:P37530" /translation="MNTAPFIAIEGPIGAGKTTLATMLSQKFGFPMINEIVEDNPYLD KFYDNIKEWSFQLEMFFLCHRYKQLEDTSDHFLKKGQPVIADYHIYKNVIFAERTLSP HQLEKYKKIYHLLTDDLPKPNFIIYIKASLPTLLHRIEKRGRPFEKKIETSYLEQLIS DYEVAIKQLQEADPELTVLTVDGDSKDFVLNKSDFERIAAHVKELIV*" /label="dgk CDS" gene complement(22737..23360) /gene="dgk" /locus_tag="BSU_00150" /old_locus_tag="BSU00150" /label="dgk gene" promotor_-10 complement(23401..23420) /Source="Nicolas_upshift_promotors" /id="U19" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.948051948051948" /psig=1 /xcortree=2605 /SigmaFactorBS="gtcaaaaagacgtttcgataatttggaaacgtcttttttTCA TGggggcacccaagggtTGTGATACAATATGAAGGTCggtaactgacgcacgtttttc a" /listShort="dgk, dck" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(23419) /Source="Nicolas_upshifts" /id="U19" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.948051948051948" /psig=1 /xcortree=2605 /SigmaFactorBS="gtcaaaaagacgtttcgataatttggaaacgtcttttttTCA TGggggcacccaagggtTGTGATACAATATGAAGGTCggtaactgacgcacgtttttc a" /listShort="dgk, dck" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(23436..23440) /Source="Nicolas_upshift_promotors" /id="U19" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.948051948051948" /psig=1 /xcortree=2605 /SigmaFactorBS="gtcaaaaagacgtttcgataatttggaaacgtcttttttTCA TGggggcacccaagggtTGTGATACAATATGAAGGTCggtaactgacgcacgtttttc a" /listShort="dgk, dck" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(23459..24742) /gene="sleL" /locus_tag="BSU_00160" /old_locus_tag="BSU00160" /EC_number="3.2.1.-" /function="16.8: Protect" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11011148, 11737650, 12177332, 10419957, 18456807, 18835992, 19933362, 28333204; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore peptidoglycan N-acetylglucosaminidase" /protein_id="NP_387897.1" /db_xref="EnsemblGenomes-Gn:BSU00160" /db_xref="EnsemblGenomes-Tr:CAB11792" /db_xref="GOA:P37531" /db_xref="InterPro:IPR001223" /db_xref="InterPro:IPR011583" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG10080" /db_xref="UniProtKB/Swiss-Prot:P37531" /translation="MVKQGDTLSAIASQYRTTTNDITETNEIPNPDSLVVGQTIVIPI AGQFYDVKRGDTLTSIARQFNTTAAELARVNRIQLNTVLQIGFRLYIPPAPKRDIESN AYLEPRGNQVSENLQQAAREASPYLTYLGAFSFQAQRNGTLVAPPLTNLRSITESQNT TLMMIITNLENQAFSDELGRILLNDETVKRRLLNEIVENARRYGFRDIHFDFEYLRPQ DREAYNQFLREARDLFHREGLEISTALAPKTSATQQGRWYEAHDYRAHGEIVDFVVLM TYEWGYSGGPPQAVSPIGPVRDVIEYALTEMPANKIVMGQNLYGYDWTLPYTAGGTPA RAVSPQQAIVIADQNNASIQYDQTAQAPFFRYTDAENRRHEVWFEDARSIQAKFNLIK ELNLRGISYWKLGLSFPQNWLLLSDQFNVVKKTFR*" /label="sleL CDS" gene complement(23459..24742) /gene="sleL" /locus_tag="BSU_00160" /old_locus_tag="BSU00160" /label="sleL gene" downshifts complement(23496) /Source="Nicolas_upshifts" /id="D10" /incds=0 /nref=40 /ntot=61 /MaxReadThrough="1.17442" /MaxDrop="6.30997" /score="3.66560192" /energy="-8.4" /TU="NA" /idTUdmin="U20" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(24773..24791) /Source="Nicolas_upshift_promotors" /id="U20" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1152 /SigmaFactorBS="tttcgcagaaattacgacggaagaacaaattatagaaaaata AACATGatcagcgcttttcttTCATACATTGATAGCGATAtgaaaggaggcgtttttc a" /listShort="yaaH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(24794) /Source="Nicolas_upshifts" /id="U20" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1152 /SigmaFactorBS="tttcgcagaaattacgacggaagaacaaattatagaaaaata AACATGatcagcgcttttcttTCATACATTGATAGCGATAtgaaaggaggcgtttttc a" /listShort="yaaH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(24807..24812) /Source="Nicolas_upshift_promotors" /id="U20" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1152 /SigmaFactorBS="tttcgcagaaattacgacggaagaacaaattatagaaaaata AACATGatcagcgcttttcttTCATACATTGATAGCGATAtgaaaggaggcgtttttc a" /listShort="yaaH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(24812..25357) /gene="yaaI" /locus_tag="BSU_00170" /old_locus_tag="BSU00170" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 2521622; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative amidase (isochorismatase family)" /protein_id="NP_387898.1" /db_xref="EnsemblGenomes-Gn:BSU00170" /db_xref="EnsemblGenomes-Tr:CAB11793" /db_xref="GOA:P37532" /db_xref="InterPro:IPR000868" /db_xref="InterPro:IPR036380" /db_xref="SubtiList:BG10081" /db_xref="UniProtKB/Swiss-Prot:P37532" /translation="MSKADKALLIVDMINNFEFDMGETLAKKTEKIVPHILSLKEHAR QNEWPIIYINDHYGLWQADIKNIQQECTNERSKDIITKIAPVDADYFLIKPKHSAFYE TALHTLLTELQVRHIIITGIAGNICVLFTANDAYMREYSITIPKDCIASNSDEDNEFA LTMMENVLFAEITTEEQIIEK*" /label="yaaI CDS" gene complement(24812..25357) /gene="yaaI" /locus_tag="BSU_00170" /old_locus_tag="BSU00170" /label="yaaI gene" promotor_-35 25223..25227 /Source="Nicolas_upshift_promotors" /id="U21" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.78921078921079" /psig="0.99000999000999" /xcortree=1810 /SigmaFactorBS="taatgatcattgatgtaaataatcggccattcattTTGTCtc gcgtgctcctttAATGATAAAATATGAGGAACgattttttctgtttttttagcgaggg t" /listShort="S16, tadA, S17, scr, S18" /listLong="dnaX, yaaK, recR, yaaL, bofA, S19, rrnA-16S" /label="promotor_-35" promotor_-10 25242..25261 /Source="Nicolas_upshift_promotors" /id="U21" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.78921078921079" /psig="0.99000999000999" /xcortree=1810 /SigmaFactorBS="taatgatcattgatgtaaataatcggccattcattTTGTCtc gcgtgctcctttAATGATAAAATATGAGGAACgattttttctgtttttttagcgaggg t" /listShort="S16, tadA, S17, scr, S18" /listLong="dnaX, yaaK, recR, yaaL, bofA, S19, rrnA-16S" /label="promotor_-10" S_feature 25246..25442 /Source="Nicolas_S_feature" /locus_tag="new_25655_25851" /HighExp="Diami, dia5, H2O2, dia15, T0.30H, T-0.40H, HiOs, T-1.10H, Salt, T0.0H" /AntisenseName="yaaI" /AntisenseCor="9.6546810160837798E-2" /AntisenseRegPval="-0.9" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S16" upshifts 25248 /Source="Nicolas_upshifts" /id="U21" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.78921078921079" /psig="0.99000999000999" /xcortree=1810 /SigmaFactorBS="taatgatcattgatgtaaataatcggccattcattTTGTCtc gcgtgctcctttAATGATAAAATATGAGGAACgattttttctgtttttttagcgaggg t" /listShort="S16, tadA, S17, scr, S18" /listLong="dnaX, yaaK, recR, yaaL, bofA, S19, rrnA-16S" /label="upshifts" promotor_-10 complement(25382..25400) /Source="Nicolas_upshift_promotors" /id="U22" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=248 /SigmaFactorBS="aaagttcatcttgtgtcataaggataagctctcttttcaaAG TTTTTtcattgcctaaaaaGGCTACATATTAACTATAActgaaacggaaaggagactg t" /listShort="yaaI, yaaH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(25401) /Source="Nicolas_upshifts" /id="U22" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=248 /SigmaFactorBS="aaagttcatcttgtgtcataaggataagctctcttttcaaAG TTTTTtcattgcctaaaaaGGCTACATATTAACTATAActgaaacggaaaggagactg t" /listShort="yaaI, yaaH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(25415..25421) /Source="Nicolas_upshift_promotors" /id="U22" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=248 /SigmaFactorBS="aaagttcatcttgtgtcataaggataagctctcttttcaaAG TTTTTtcattgcctaaaaaGGCTACATATTAACTATAActgaaacggaaaggagactg t" /listShort="yaaI, yaaH" /GFF_Attribute="listLong" /label="promotor_-35" CDS 25443..25928 /gene="tadA" /locus_tag="BSU_00180" /old_locus_tag="BSU00180" /EC_number="3.5.4.33" /function="10.3: tRNA and rRNA base modification" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15677468, 16014871, 16415880, 16700551, 23658230; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA specific adenosine A34 deaminase" /protein_id="NP_387899.1" /db_xref="EnsemblGenomes-Gn:BSU00180" /db_xref="EnsemblGenomes-Tr:CAB11794" /db_xref="GOA:P21335" /db_xref="InterPro:IPR002125" /db_xref="InterPro:IPR016192" /db_xref="InterPro:IPR016193" /db_xref="InterPro:IPR028883" /db_xref="SubtiList:BG10082" /db_xref="UniProtKB/Swiss-Prot:P21335" /translation="MTQDELYMKEAIKEAKKAEEKGEVPIGAVLVINGEIIARAHNLR ETEQRSIAHAEMLVIDEACKALGTWRLEGATLYVTLEPCPMCAGAVVLSRVEKVVFGA FDPKGGCSGTLMNLLQEERFNHQAEVVSGVLEEECGGMLSAFFRELRKKKKAARKNLS E*" /label="tadA CDS" gene 25443..25928 /gene="tadA" /locus_tag="BSU_00180" /old_locus_tag="BSU00180" /label="tadA gene" promotor_-35 25932..25938 /Source="Nicolas_upshift_promotors" /id="U23" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.403596403596404" /psig="0.899100899100899" /xcortree=1436 /SigmaFactorBS="aacttgtctgaatagtacGGTTGCAatttttaggggaaACAG ATATACTTAAGTGTGCatcgtaatagatgcaacataaaatttgatatttattttgccg t" /listShort="S17, scr, S18" /listLong="dnaX, yaaK, recR, yaaL, bofA, S19, rrnA-16S" /label="promotor_-35" promotor_-10 25952..25971 /Source="Nicolas_upshift_promotors" /id="U23" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.403596403596404" /psig="0.899100899100899" /xcortree=1436 /SigmaFactorBS="aacttgtctgaatagtacGGTTGCAatttttaggggaaACAG ATATACTTAAGTGTGCatcgtaatagatgcaacataaaatttgatatttattttgccg t" /listShort="S17, scr, S18" /listLong="dnaX, yaaK, recR, yaaL, bofA, S19, rrnA-16S" /label="promotor_-10" misc_RNA 25970..26323 /gene="scr" /locus_tag="BSU_misc_RNA_2" /product="small cytoplasmic RNA (scRNA, 4.5S RNA), signal recognition particle-like (SRP) component" /experiment="publication(s) with functional evidences, PMID:1372600, 1689715" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1372600, 1689715" /label="scr RNA" gene 25970..26323 /gene="scr" /locus_tag="BSU_misc_RNA_2" /label="scr gene" S_feature 25974..26123 /Source="Nicolas_S_feature" /locus_tag="new_26383_26532" /HighExp="T1.0H, T5.0H, T1.30H, T3.30H, T3.0H, T2.30H, T4.0H, S8, T-1.10H, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.899, 0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S17" upshifts 25974 /Source="Nicolas_upshifts" /id="U23" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.403596403596404" /psig="0.899100899100899" /xcortree=1436 /SigmaFactorBS="aacttgtctgaatagtacGGTTGCAatttttaggggaaACAG ATATACTTAAGTGTGCatcgtaatagatgcaacataaaatttgatatttattttgccg t" /listShort="S17, scr, S18" /listLong="dnaX, yaaK, recR, yaaL, bofA, S19, rrnA-16S" /label="upshifts" S_feature 26227..26322 /Source="Nicolas_S_feature" /locus_tag="new_26636_26731" /HighExp="S8, Sw, B60, B36, T2.30H, T3.30H, T1.0H, BC, T4.0H, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.899, 0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S18" downshifts 26279 /Source="Nicolas_upshifts" /id="D11" /incds=0 /nref=273 /ntot=278 /MaxReadThrough="4.46774" /MaxDrop="8.31255" /score="23.257527" /energy="-10.3" /TU="U21,U23" /idTUdmin="U21" /TUdmin="-89" /isTUend="FALSE" /label="downshifts" promotor_-35 26343..26346 /Source="Nicolas_upshift_promotors" /id="U24" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.863136863136863" /psig=1 /xcortree=2612 /SigmaFactorBS="attaggtgagttttttgttatgtaaaaagagctTTTGgaatc gaaacaaggTTCATGTATAATGGGAATGAtgaataacggaggagggcaaacccgtgag t" /listShort="dnaX, yaaK, recR, yaaL, bofA" /listLong="S19, rrnA-16S" /label="promotor_-35" promotor_-10 26361..26380 /Source="Nicolas_upshift_promotors" /id="U24" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.863136863136863" /psig=1 /xcortree=2612 /SigmaFactorBS="attaggtgagttttttgttatgtaaaaagagctTTTGgaatc gaaacaaggTTCATGTATAATGGGAATGAtgaataacggaggagggcaaacccgtgag t" /listShort="dnaX, yaaK, recR, yaaL, bofA" /listLong="S19, rrnA-16S" /label="promotor_-10" upshifts 26370 /Source="Nicolas_upshifts" /id="U24" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.863136863136863" /psig=1 /xcortree=2612 /SigmaFactorBS="attaggtgagttttttgttatgtaaaaagagctTTTGgaatc gaaacaaggTTCATGTATAATGGGAATGAtgaataacggaggagggcaaacccgtgag t" /listShort="dnaX, yaaK, recR, yaaL, bofA" /listLong="S19, rrnA-16S" /label="upshifts" CDS 26405..28096 /gene="dnaX" /locus_tag="BSU_00190" /old_locus_tag="BSU00190" /EC_number="2.7.7.7" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:9341154, 10844689, 12466528, 12974630, 14757052, 15927750, 25850333, 26786318" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9341154, 10844689, 12466528, 12974630, 14757052, 15927750, 25850333, 26786318; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA polymerase III subunit tau subunit" /protein_id="NP_387900.2" /db_xref="EnsemblGenomes-Gn:BSU00190" /db_xref="EnsemblGenomes-Tr:CAB11795" /db_xref="GOA:P09122" /db_xref="InterPro:IPR001270" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR008921" /db_xref="InterPro:IPR012763" /db_xref="InterPro:IPR022754" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10083" /db_xref="UniProtKB/Swiss-Prot:P09122" /translation="MSYQALYRVFRPQRFEDVVGQEHITKTLQNALLQKKFSHAYLFS GPRGTGKTSAAKIFAKAVNCEHAPVDEPCNECAACKGITNGSISDVIEIDAASNNGVD EIRDIRDKVKFAPSAVTYKVYIIDEVHMLSIGAFNALLKTLEEPPEHCIFILATTEPH KIPLTIISRCQRFDFKRITSQAIVGRMNKIVDAEQLQVEEGSLEIIASAADGGMRDAL SLLDQAISFSGDILKVEDALLITGAVSQLYIGKLAKSLHDKNVSDALETLNELLQQGK DPAKLIEDMIFYFRDMLLYKTAPGLEGVLEKVKVDETFRELSEQIPAQALYEMIDILN KSHQEMKWTNHPRIFFEVAVVKICQTSHQSAADLPEVDMLMKKIQQLEQEVERLKTTG IKAAAESPKKEAPRVPKGGKSNYKAPVGRIHEILKEATRPDLDLLRNSWGKLLAHLKQ QNKVSHAALLNDSEPVAAGSAAFVLKFKYEIHCKMVAEDNNGVRTNLEQILESMLGKR MDLIGVPEAQWGKIREEFLEDHQQENEGSNEPAEEDPLIAEAKKLVGADLIEIKD*" /label="dnaX CDS" gene 26405..28096 /gene="dnaX" /locus_tag="BSU_00190" /old_locus_tag="BSU00190" /label="dnaX gene" promotor_-35 27937..27944 /Source="Nicolas_upshift_promotors" /id="U25" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.761238761238761" /psig="0.999000999001" /xcortree=1923 /SigmaFactorBS="atgctcggaaaaagaatggatttGATTGGCGttccagaagca caaTGGGGTAAAATAAGAGAAGAatttttagaagatcatcagcaggaaaatgaaggat c" /listShort="yaaK, recR, yaaL, bofA" /listLong="S19, rrnA-16S" /label="promotor_-35" promotor_-10 27959..27978 /Source="Nicolas_upshift_promotors" /id="U25" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.761238761238761" /psig="0.999000999001" /xcortree=1923 /SigmaFactorBS="atgctcggaaaaagaatggatttGATTGGCGttccagaagca caaTGGGGTAAAATAAGAGAAGAatttttagaagatcatcagcaggaaaatgaaggat c" /listShort="yaaK, recR, yaaL, bofA" /listLong="S19, rrnA-16S" /label="promotor_-10" upshifts 27974 /Source="Nicolas_upshifts" /id="U25" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.761238761238761" /psig="0.999000999001" /xcortree=1923 /SigmaFactorBS="atgctcggaaaaagaatggatttGATTGGCGttccagaagca caaTGGGGTAAAATAAGAGAAGAatttttagaagatcatcagcaggaaaatgaaggat c" /listShort="yaaK, recR, yaaL, bofA" /listLong="S19, rrnA-16S" /label="upshifts" CDS 28120..28443 /gene="ebfC" /locus_tag="BSU_00200" /old_locus_tag="BSU00200" /function="16.9: Replicate" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16740939, 19208644, 19594923, 20639362, 22333191, 22544270; Product type f : factor" /codon_start=1 /transl_table=11 /product="nucleoid associated protein" /protein_id="NP_387901.1" /db_xref="EnsemblGenomes-Gn:BSU00200" /db_xref="EnsemblGenomes-Tr:CAB11796" /db_xref="GOA:P24281" /db_xref="InterPro:IPR004401" /db_xref="InterPro:IPR036894" /db_xref="SubtiList:BG10084" /db_xref="UniProtKB/Swiss-Prot:P24281" /translation="MRGGMGNMQKMMKQMQKMQKDMAKAQEELAEKVVEGTAGGGMVT VKANGQKEILDVIIKEEVVDPEDIDMLQDLVLAATNEALKKVDEITNETMGQFTKGMN MPGLF*" /label="ebfC CDS" gene 28120..28443 /gene="ebfC" /locus_tag="BSU_00200" /old_locus_tag="BSU00200" /label="ebfC gene" CDS 28458..29054 /gene="recR" /locus_tag="BSU_00210" /old_locus_tag="BSU00210" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12065426, 24285298, 24891441" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12065426, 24285298, 24891441; Product type f: factor" /codon_start=1 /transl_table=11 /product="recA filament-DNA complex stabilisation factor" /protein_id="NP_387902.1" /db_xref="EnsemblGenomes-Gn:BSU00210" /db_xref="EnsemblGenomes-Tr:CAB11797" /db_xref="GOA:P24277" /db_xref="InterPro:IPR000093" /db_xref="InterPro:IPR006171" /db_xref="InterPro:IPR015967" /db_xref="InterPro:IPR023170" /db_xref="InterPro:IPR023627" /db_xref="InterPro:IPR023628" /db_xref="InterPro:IPR034137" /db_xref="SubtiList:BG10085" /db_xref="UniProtKB/Swiss-Prot:P24277" /translation="MQYPEPISKLIDSFMKLPGIGPKTAVRLAFFVLGMKEDVVLDFA KALVNAKRNLTYCSVCGHITDQDPCYICEDTRRDKSVICVVQDPKDVIAMEKMKEYNG QYHVLHGAISPMDGIGPEDIKIPELLKRLQDDQVTEVILATNPNIEGEATAMYISRLL KPSGIKLSRIAHGLPVGGDLEYADEVTLSKALEGRREL*" /label="recR CDS" gene 28458..29054 /gene="recR" /locus_tag="BSU_00210" /old_locus_tag="BSU00210" /label="recR gene" CDS 29072..29296 /gene="yaaL" /locus_tag="BSU_00220" /old_locus_tag="BSU00220" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_387903.1" /db_xref="EnsemblGenomes-Gn:BSU00220" /db_xref="EnsemblGenomes-Tr:CAB11798" /db_xref="InterPro:IPR019644" /db_xref="SubtiList:BG10086" /db_xref="UniProtKB/Swiss-Prot:P37533" /translation="MGFLRKKTLRREFDEKLTEQLFKQKEEWNRQKKLVEKSLEPSAE VLYELKVAEAKYFFYLREAKQRNLKISRWK*" /label="yaaL CDS" gene 29072..29296 /gene="yaaL" /locus_tag="BSU_00220" /old_locus_tag="BSU00220" /label="yaaL gene" promotor_-35 29299..29304 /Source="Nicolas_upshift_promotors" /id="U26" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1161 /SigmaFactorBS="aagcgaagcagcgaaatttaaaaatcagccggtggaagtaag tGGTCTAaactcctggatcttcTCATAAGCTTGTACTAGAAcaagcgaaggagatgag a" /listShort="bofA, S19" /listLong="rrnA-16S" /label="promotor_-35" upshifts 29316 /Source="Nicolas_upshifts" /id="U26" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1161 /SigmaFactorBS="aagcgaagcagcgaaatttaaaaatcagccggtggaagtaag tGGTCTAaactcctggatcttcTCATAAGCTTGTACTAGAAcaagcgaaggagatgag a" /listShort="bofA, S19" /listLong="rrnA-16S" /label="upshifts" promotor_-10 29320..29338 /Source="Nicolas_upshift_promotors" /id="U26" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1161 /SigmaFactorBS="aagcgaagcagcgaaatttaaaaatcagccggtggaagtaag tGGTCTAaactcctggatcttcTCATAAGCTTGTACTAGAAcaagcgaaggagatgag a" /listShort="bofA, S19" /listLong="rrnA-16S" /label="promotor_-10" CDS 29363..29626 /gene="bofA" /locus_tag="BSU_00230" /old_locus_tag="BSU00230" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15087499, 17557826" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15087499, 17557826; Product type r: regulator" /codon_start=1 /transl_table=11 /product="inhibitor of the pro-sigma(K) processing machinery" /protein_id="NP_387904.2" /db_xref="EnsemblGenomes-Gn:BSU00230" /db_xref="EnsemblGenomes-Tr:CAB11799" /db_xref="GOA:P24282" /db_xref="InterPro:IPR010001" /db_xref="SubtiList:BG10087" /db_xref="UniProtKB/Swiss-Prot:P24282" /translation="MEPIFIIGIILGLVILLFLSGSAAKPLKWIGITAVKFVAGALLL VCVNMFGGSLGIHVPINLVTTAISGILGIPGIAALVVIKQFII*" /label="bofA CDS" gene 29363..29626 /gene="bofA" /locus_tag="BSU_00230" /old_locus_tag="BSU00230" /label="bofA gene" promotor_-35 29639..29646 /Source="Nicolas_upshift_promotors" /id="U27" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2620 /SigmaFactorBS="ttaagcaatttatcatttaattgatattatgtATTGACTTag acaactgaaggTGTTATTCTAATATACGTCGctgatgacgaacagcttttttgaaaag a" /listShort="S19, rrnA-16S" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 29660..29679 /Source="Nicolas_upshift_promotors" /id="U27" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2620 /SigmaFactorBS="ttaagcaatttatcatttaattgatattatgtATTGACTTag acaactgaaggTGTTATTCTAATATACGTCGctgatgacgaacagcttttttgaaaag a" /listShort="S19, rrnA-16S" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 29667..29869 /Source="Nicolas_S_feature" /locus_tag="new_30076_30278" /HighExp="LBGstat, Diami, C30, H2O2, Oxctl, HPh, BMM, GM 120, Paraq, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="1, 1" /TUlongSig="SigA, SigA, SigA, SigA" /TUlongPSig="0.999, 1, 0.899, 0.99" /label="S19" upshifts 29667 /Source="Nicolas_upshifts" /id="U27" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2620 /SigmaFactorBS="ttaagcaatttatcatttaattgatattatgtATTGACTTag acaactgaaggTGTTATTCTAATATACGTCGctgatgacgaacagcttttttgaaaag a" /listShort="S19, rrnA-16S" /GFF_Attribute="listLong" /label="upshifts" rRNA 29870..31423 /gene="rrnA-16S" /locus_tag="BSU_rRNA_4" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnA-16S" gene 29870..31423 /gene="rrnA-16S" /locus_tag="BSU_rRNA_4" /label="rrnA-16S gene" tRNA 31523..31599 /gene="trnA-Ile" /locus_tag="BSU_tRNA_8" /product="tRNA-Ile" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ile(GAU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnA-Ile" gene 31523..31599 /gene="trnA-Ile" /locus_tag="BSU_tRNA_8" /label="trnA-Ile gene" tRNA 31611..31686 /gene="trnA-Ala" /locus_tag="BSU_tRNA_9" /product="tRNA-Ala" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ala(UGC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnA-Ala" gene 31611..31686 /gene="trnA-Ala" /locus_tag="BSU_tRNA_9" /label="trnA-Ala gene" rRNA 31768..34694 /gene="rrnA-23S" /locus_tag="BSU_rRNA_5" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnA-23S" gene 31768..34694 /gene="rrnA-23S" /locus_tag="BSU_rRNA_5" /label="rrnA-23S gene" S_feature 34695..34827 /Source="Nicolas_S_feature" /locus_tag="new_35104_35236" /HighExp="LBGstat, G135, Oxctl, C30, HPh, Paraq, G180, LPh, T0.30H, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S20" rRNA 34828..34946 /gene="rrnA-5S" /locus_tag="BSU_rRNA_26" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnA-5S" gene 34828..34946 /gene="rrnA-5S" /locus_tag="BSU_rRNA_26" /label="rrnA-5S gene" S_feature 34947..35049 /Source="Nicolas_S_feature" /locus_tag="new_35356_35458" /HighExp="Oxctl, Paraq, H2O2, LBGstat, C30, G180, Cold, G135, Heat, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S21" promotor_-35 35010..35018 /Source="Nicolas_upshift_promotors" /id="U28" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.715284715284715" /psig="0.715284715284715" /xcortree=1057 /SigmaFactorBS="cgagaaaatcaaacaaataCAAACACCGagggcttatatagC CCATATACTGATTTAAAGTttcaaaaaggtctaaatagtgtatacaatatccgtttta a" /listShort="csfB, xpaC, yaaN, S22, yaaO, tmk" /listLong="yaaQ, yaaR, holB, yaaT" /label="promotor_-35" promotor_-10 35032..35051 /Source="Nicolas_upshift_promotors" /id="U28" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.715284715284715" /psig="0.715284715284715" /xcortree=1057 /SigmaFactorBS="cgagaaaatcaaacaaataCAAACACCGagggcttatatagC CCATATACTGATTTAAAGTttcaaaaaggtctaaatagtgtatacaatatccgtttta a" /listShort="csfB, xpaC, yaaN, S22, yaaO, tmk" /listLong="yaaQ, yaaR, holB, yaaT" /label="promotor_-10" upshifts 35051 /Source="Nicolas_upshifts" /id="U28" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.715284715284715" /psig="0.715284715284715" /xcortree=1057 /SigmaFactorBS="cgagaaaatcaaacaaataCAAACACCGagggcttatatagC CCATATACTGATTTAAAGTttcaaaaaggtctaaatagtgtatacaatatccgtttta a" /listShort="csfB, xpaC, yaaN, S22, yaaO, tmk" /listLong="yaaQ, yaaR, holB, yaaT" /label="upshifts" CDS 35122..35316 /gene="csfB" /locus_tag="BSU_00240" /old_locus_tag="BSU00240" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:8759874, 15044948, 21935351, 26929302" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8759874, 15044948, 21935351, 26929302; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="forespore-specific anti-sigma factor" /protein_id="NP_387905.1" /db_xref="EnsemblGenomes-Gn:BSU00240" /db_xref="EnsemblGenomes-Tr:CAB11800" /db_xref="GOA:P37534" /db_xref="InterPro:IPR019700" /db_xref="SubtiList:BG10088" /db_xref="UniProtKB/Swiss-Prot:P37534" /translation="MDETVKLNHTCVICDQEKNRGIHLYTKFICLDCERKVISTSTSD PDYAFYVKKLKSIHTPPLYS*" /label="csfB CDS" gene 35122..35316 /gene="csfB" /locus_tag="BSU_00240" /old_locus_tag="BSU00240" /label="csfB gene" downshifts 35300 /Source="Nicolas_upshifts" /id="D12" /incds=0 /nref=79 /ntot=215 /MaxReadThrough="5.37774" /MaxDrop="4.42494" /score="22.3916007" /energy="-6.7" /TU="U28" /idTUdmin="U27" /TUdmin=3938 /isTUend="FALSE" /label="downshifts" promotor_-35 35361..35370 /Source="Nicolas_upshift_promotors" /id="U29" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1675 /SigmaFactorBS="tctttttttgtactcttaataataaaaagaagaTGAAACTTG TttaaggattgaACGTAGTAGATAATAAtattaaaactgagtatagacacaggagtcg a" /listShort="xpaC, yaaN, S22, yaaO, tmk, yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 35382..35397 /Source="Nicolas_upshift_promotors" /id="U29" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1675 /SigmaFactorBS="tctttttttgtactcttaataataaaaagaagaTGAAACTTG TttaaggattgaACGTAGTAGATAATAAtattaaaactgagtatagacacaggagtcg a" /listShort="xpaC, yaaN, S22, yaaO, tmk, yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 35388 /Source="Nicolas_upshifts" /id="U29" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1675 /SigmaFactorBS="tctttttttgtactcttaataataaaaagaagaTGAAACTTG TttaaggattgaACGTAGTAGATAATAAtattaaaactgagtatagacacaggagtcg a" /listShort="xpaC, yaaN, S22, yaaO, tmk, yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /GFF_Attribute="listLong" /label="upshifts" CDS 35436..36050 /gene="xpaC" /locus_tag="BSU_00250" /old_locus_tag="BSU00250" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23155385; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphatase" /protein_id="NP_387906.1" /db_xref="EnsemblGenomes-Gn:BSU00250" /db_xref="EnsemblGenomes-Tr:CAB11801" /db_xref="GOA:P37467" /db_xref="InterPro:IPR018770" /db_xref="SubtiList:BG10089" /db_xref="UniProtKB/Swiss-Prot:P37467" /translation="MQRFFHFLVWSLTSSATFVFIGILSFFGLNQSIFLSIVYGLASG AAVYIAGIWNARRLFLKKHELTGREYAYIKKNLEEARQKMVRLRKALFQAKSIQMFKQ NAEMLRIVRRIYLLTKKEPKRFYQAERFFYQTLDSVVELTEKYAFLSSHPKKSKELSM SLSETRITLTELTKRLEEDLTQAMGDEIDELQFELDAAKHSLKK*" /label="xpaC CDS" gene 35436..36050 /gene="xpaC" /locus_tag="BSU_00250" /old_locus_tag="BSU00250" /label="xpaC gene" CDS 36069..37229 /gene="yaaN" /locus_tag="BSU_00260" /old_locus_tag="BSU00260" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12533473, 20713661" /codon_start=1 /transl_table=11 /product="putative toxic compound resistance protein" /protein_id="NP_387907.1" /db_xref="EnsemblGenomes-Gn:BSU00260" /db_xref="EnsemblGenomes-Tr:CAB11802" /db_xref="InterPro:IPR008863" /db_xref="SubtiList:BG10090" /db_xref="UniProtKB/Swiss-Prot:P37535" /translation="MNRDQSDLHIDELLADPFGGNIEIPGSEAVKAEKEQVRLVDVLP EENKEKAIQLAGQIDHKNMQSIVLYGSQAQSKLLNFSHDMINHVQKKDVGEIGEILGE LMKKLEQVNPDDLQSKKKGFLARMFGRVSSSLQEVLSKYQKTSVQIDRISLKLEHSKN ALISDNKLLEQLYEKNKEYFAALNVYIAAGELKLEELKTKTIPELKQQAESSDHNQMA VQEVNDLIQFADRLDKRVHDLLLSRQITIQSAPQIRLIQNTNQALAEKIQSSIVTAIP LWKNQVAIALTLLRQRNAVDAQQKVSDTTNELLLKNAELLKTNTIETARANERGLVDI DTLKKVQESLISTLEETLTIQEEGRIKRRQAEEELMMMEGDLKQKLITIKER*" /label="yaaN CDS" gene 36069..37229 /gene="yaaN" /locus_tag="BSU_00260" /old_locus_tag="BSU00260" /label="yaaN gene" S_feature 37230..37310 /Source="Nicolas_S_feature" /locus_tag="new_37639_37719" /HighExp="T0.0H, T-0.40H, T0.30H, T-1.10H, T-1.40H, Salt, T1.0H, G150, Diami, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY, SigK" /TUshortPSig="0.984, 0.715" /TUlongSig="NA" /TUlongPSig="NA" /label="S22" CDS 37311..38753 /gene="yaaO" /locus_tag="BSU_00270" /old_locus_tag="BSU00270" /EC_number="4.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9723923, 20876533, 24529384; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative decarboxylase" /protein_id="NP_387908.1" /db_xref="EnsemblGenomes-Gn:BSU00270" /db_xref="EnsemblGenomes-Tr:CAB11803" /db_xref="GOA:P37536" /db_xref="InterPro:IPR000310" /db_xref="InterPro:IPR008286" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036633" /db_xref="SubtiList:BG10091" /db_xref="UniProtKB/Swiss-Prot:P37536" /translation="MNTPLYKALIQHARRNSHSFHVPGHHNGDVFFDDAKSIFDPLLT IDVTELAGLDDLHHPSGVIKEAQELASQLYGSAESFFLVNGTTVGNLAMILSVCEPGD TILVQRNCHKSVFHAVDLSGAEPVYLAPDVDSAMHVPTHVPLGTIKEALEAYPDAKGL VLTNPTYYGHSADLTEIITEAHHYGIPVLVDEAHGAHFILGEPFPVSALKMGADIVVQ SAHKTLPAMTMGSYLHLNSSCRINRDRVAEYLNRLQSSSPSYPIMASLDIARAYVQHI IEEQKLSDILQRIETLKQTFDSLTNAEAVNPANPLIITDPLKLTIRSKRGHSGYTLQS ILERANIFTELADENQVLLVLPLGGKRRINAEIIRSIDEEIEKTPPDQTFVSAEWGVQ PVTVLPYPKKVLHSFKKEYVSFEEAAGRLNAEDIIPYPPGIPMIMAGERITKESVQKL SRLISMKTHVQGNMKIKEKQLLVYIEEEKS*" /label="yaaO CDS" gene 37311..38753 /gene="yaaO" /locus_tag="BSU_00270" /old_locus_tag="BSU00270" /label="yaaO gene" promotor_-35 38673..38679 /Source="Nicolas_upshift_promotors" /id="U30" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.513486513486514" /psig="0.513486513486514" /xcortree=105 /SigmaFactorBS="gaaagtgtgcaaaagctcagccgcttgatcAGCATGAaaacg catgttcaaGGGAATATGAAAATCAAAGagaaacaactacttgtttatatagaagagg a" /listShort="tmk" /listLong="yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /label="promotor_-35" promotor_-10 38694..38712 /Source="Nicolas_upshift_promotors" /id="U30" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.513486513486514" /psig="0.513486513486514" /xcortree=105 /SigmaFactorBS="gaaagtgtgcaaaagctcagccgcttgatcAGCATGAaaacg catgttcaaGGGAATATGAAAATCAAAGagaaacaactacttgtttatatagaagagg a" /listShort="tmk" /listLong="yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /label="promotor_-10" upshifts 38703 /Source="Nicolas_upshifts" /id="U30" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.513486513486514" /psig="0.513486513486514" /xcortree=105 /SigmaFactorBS="gaaagtgtgcaaaagctcagccgcttgatcAGCATGAaaacg catgttcaaGGGAATATGAAAATCAAAGagaaacaactacttgtttatatagaagagg a" /listShort="tmk" /listLong="yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /label="upshifts" CDS 38750..39388 /gene="tmk" /locus_tag="BSU_00280" /old_locus_tag="BSU00280" /EC_number="2.7.4.9" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9696781, 12682299, 18523102" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9696781, 12682299, 18523102; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thymidylate kinase" /protein_id="NP_387909.2" /db_xref="EnsemblGenomes-Gn:BSU00280" /db_xref="EnsemblGenomes-Tr:CAB11804" /db_xref="GOA:P37537" /db_xref="InterPro:IPR018094" /db_xref="InterPro:IPR018095" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10092" /db_xref="UniProtKB/Swiss-Prot:P37537" /translation="MSGLFITFEGPEGAGKTTVLQEIKNILTAEGLQVMATREPGGID IAEQIREVILNENNILMDPKTEALLYAAARRQHLVEKVKPALEQGFIVLCDRFIDSSL AYQGYARGLGIDEVLSINEFAIGDMMPHVTVYFSIDPEEGLKRIYANGSREKNRLDLE KLDFHTKVQEGYQELMKRFPERFHSVDAGQSKDLVVQDVLKVIDEALKKIQL*" /label="tmk CDS" gene 38750..39388 /gene="tmk" /locus_tag="BSU_00280" /old_locus_tag="BSU00280" /label="tmk gene" promotor_-35 39383..39390 /Source="Nicolas_upshift_promotors" /id="U31" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.478521478521479" /psig="0.964035964035964" /xcortree=91 /SigmaFactorBS="tgatcgatgaagcgttgaaaaaaattcaaTTGTGACCtgttt cccaataGTTGATATAATAATGTAAACgagatcacgttgtttccaatctaaaggaggc c" /listShort="yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 39403..39422 /Source="Nicolas_upshift_promotors" /id="U31" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.478521478521479" /psig="0.964035964035964" /xcortree=91 /SigmaFactorBS="tgatcgatgaagcgttgaaaaaaattcaaTTGTGACCtgttt cccaataGTTGATATAATAATGTAAACgagatcacgttgtttccaatctaaaggaggc c" /listShort="yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 39414 /Source="Nicolas_upshifts" /id="U31" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.478521478521479" /psig="0.964035964035964" /xcortree=91 /SigmaFactorBS="tgatcgatgaagcgttgaaaaaaattcaaTTGTGACCtgttt cccaataGTTGATATAATAATGTAAACgagatcacgttgtttccaatctaaaggaggc c" /listShort="yaaQ, yaaR, holB, yaaT, yabA, yabB, yazA, yabC" /GFF_Attribute="listLong" /label="upshifts" CDS 39462..39791 /gene="darA" /locus_tag="BSU_00290" /old_locus_tag="BSU00290" /experiment="publication(s) with functional evidences, PMID:10913081, 25433025" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10913081, 25433025; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="signal transduction receptor, cyclic di-AMP binding" /protein_id="NP_387910.1" /db_xref="EnsemblGenomes-Gn:BSU00290" /db_xref="EnsemblGenomes-Tr:CAB11805" /db_xref="InterPro:IPR010375" /db_xref="InterPro:IPR011322" /db_xref="InterPro:IPR015867" /db_xref="PDB:4RLE" /db_xref="SubtiList:BG10093" /db_xref="UniProtKB/Swiss-Prot:P37538" /translation="MKLIVAVVQDQDSNRLLKTLTDHNFRVTKLATTGGFLKSGNTTF MIGVEDIRVNKALSLIKENGQKRDQMIAPVSPMGGNADSYVPYPVEVEVGGATVFVLP VDEFHQF*" /label="darA CDS" gene 39462..39791 /gene="darA" /locus_tag="BSU_00290" /old_locus_tag="BSU00290" /label="darA gene" CDS 39804..40244 /gene="yaaR" /locus_tag="BSU_00300" /old_locus_tag="BSU00300" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22333191, 22720735" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_387911.1" /db_xref="EnsemblGenomes-Gn:BSU00300" /db_xref="EnsemblGenomes-Tr:CAB11806" /db_xref="InterPro:IPR005585" /db_xref="InterPro:IPR024042" /db_xref="SubtiList:BG10094" /db_xref="UniProtKB/Swiss-Prot:P37539" /translation="MKINKDIRTFIDNKQIPSVKTSEITASFKTSMENQSSKMKLDQL TRLLSDIEAFGKRLTKSRNFKDLARFKGLVKRFVKEAVDSGLSHETSKSFDLYGNSRT LGLVKEIDDKLIQLTEEMMDQEKPAIDLLERIGEIKGLLINLYT*" /label="yaaR CDS" gene 39804..40244 /gene="yaaR" /locus_tag="BSU_00300" /old_locus_tag="BSU00300" /label="yaaR gene" CDS 40256..41245 /gene="holB" /locus_tag="BSU_00310" /old_locus_tag="BSU00310" /EC_number="2.7.7.7" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:8509334, 12060778, 12682299, 22333191, 23525462" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8509334, 12060778, 12682299, 22333191, 23525462; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA polymerase III clamp loader delta' subunit" /protein_id="NP_387912.1" /db_xref="EnsemblGenomes-Gn:BSU00310" /db_xref="EnsemblGenomes-Tr:CAB11807" /db_xref="GOA:P37540" /db_xref="InterPro:IPR004622" /db_xref="InterPro:IPR015199" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10095" /db_xref="UniProtKB/Swiss-Prot:P37540" /translation="MAISWKEMNELQPRVMKLLYNSIEKDRLSHAYLFEGKKGTGKLD AALLLAKSFFCLEGGAEPCESCRNCKRIESGNHPDLHLVQPDGLSIKKAQIQALQEEF SKTGLESHKKLYIISHADQMTANAANSLLKFLEEPNKDTMAVLITEQPQRLLDTIISR CQTLPFQPLQPKAIEDRLIEQDVSPHMARLLANMTNNVAEAVELSRNDEFAESRAKVI KLYEVLHQRKGHAFFFIQDQWMPFFKEKTHQEMGLDMLLLIYRDVLSIQIGNEDKLIY QDLFQSIKQHALQSTQQSVTNQILAVLEAKKRLHSNVNVQGLMEHLVLMLQEG*" /label="holB CDS" gene 40256..41245 /gene="holB" /locus_tag="BSU_00310" /old_locus_tag="BSU00310" /label="holB gene" CDS 41248..42075 /gene="ricT" /locus_tag="BSU_00320" /old_locus_tag="BSU00320" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12270811, 23490197, 26434553, 27501195, 28295778" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12270811, 23490197, 26434553, 27501195, 28295778; Product type r: regulator" /codon_start=1 /transl_table=11 /product="subunit of a sporulation, competence and biofilmformation regulatory complex of RNaseY (RicAFT complex /FAD / two [4Fe-4S]2+)" /protein_id="NP_387913.1" /db_xref="EnsemblGenomes-Gn:BSU00320" /db_xref="EnsemblGenomes-Tr:CAB11808" /db_xref="GOA:P37541" /db_xref="InterPro:IPR007557" /db_xref="SubtiList:BG10096" /db_xref="UniProtKB/Swiss-Prot:P37541" /translation="MYNVIGVRFKKAGKIYYFDPNGFHIEHDSCVIVETVRGVEYGQV VIANKQVDEHDVVLPLRKVIRVADDRDLLIVEENKQEALSAFDICQKKVIEHGLDMKL VDVEFTFDRNKVIFYFTADGRVDFRELVKDLASIFKTRIELRQIGVRDEAKMLGGIGP CGRMLCCSTFLGDFEPVSIKMAKDQNLSLNPTKISGLCGRLMCCLKYENDEYETAKEQ LPDIGEMITTANGPAKVVGLNILERVLQVELINREKVIEYTWEELLEEGVVSAQTTD* " /label="ricT CDS" gene 41248..42075 /gene="ricT" /locus_tag="BSU_00320" /old_locus_tag="BSU00320" /label="ricT gene" CDS 42090..42449 /gene="dnaH" /locus_tag="BSU_00330" /old_locus_tag="BSU00330" /function="16.9: Replicate" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15927750, 16461910, 19737352, 21895792, 23909787, 28166228" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15927750, 16461910, 19737352, 21895792, 23909787, 28166228; Product type f : factor" /codon_start=1 /transl_table=11 /product="subunit of the DNA replication complex" /protein_id="NP_387914.1" /db_xref="EnsemblGenomes-Gn:BSU00330" /db_xref="EnsemblGenomes-Tr:CAB11809" /db_xref="GOA:P37542" /db_xref="InterPro:IPR010377" /db_xref="PDB:5DOL" /db_xref="SubtiList:BG10097" /db_xref="UniProtKB/Swiss-Prot:P37542" /translation="MDKKELFDTVINLEEQIGSLYRQLGDLKQHIGEMIEENHHLQLE NKHLRKRLDDTTQQIEKFKADKKESKTQKTEQTDIGEGYDNLARLYQEGFHICNVHYG SVRKEDCLFCLSFLNKK*" /label="dnaH CDS" gene 42090..42449 /gene="dnaH" /locus_tag="BSU_00330" /old_locus_tag="BSU00330" /label="dnaH gene" CDS 42508..43251 /gene="trmNF" /locus_tag="BSU_00340" /old_locus_tag="BSU00340" /EC_number="2.1.1.223" /function="10.3: tRNA and rRNA base modification" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 22905870, 24809820; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA1(Val) (adenine(37)-N6)-methyltransferase" /protein_id="NP_387915.1" /db_xref="EnsemblGenomes-Gn:BSU00340" /db_xref="EnsemblGenomes-Tr:CAB11810" /db_xref="GOA:P37543" /db_xref="InterPro:IPR007848" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG10098" /db_xref="UniProtKB/Swiss-Prot:P37543" /translation="MVSLHDDERLDYLLAEDMKIIQSPTVFAFSLDAVLLSKFAYVPI QKGKIVDLCTGNGIVPLLLSTRSKADILGVEIQERLHDMAVRSVEYNKLDDQIQIIHD DLKNMPEKLGHNRYDVVTCNPPYFKTPKQTEQNMNEHLRIARHEIHCTLEDVISVSSK LLKQGGKAALVHRPGRLLEIFELMKAYQIEPKRVQFVYPKQGKEANTILVEGIKGGRP DLKILPPLFVYDEQNEYTKEIRTILYGDK*" /label="trmNF CDS" gene 42508..43251 /gene="trmNF" /locus_tag="BSU_00340" /old_locus_tag="BSU00340" /label="trmNF gene" CDS 43238..43537 /gene="yazA" /locus_tag="BSU_00350" /old_locus_tag="BSU00350" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11483577; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative UvrC-Intron-type (URI) endonuclease" /protein_id="NP_387916.1" /db_xref="EnsemblGenomes-Gn:BSU00350" /db_xref="EnsemblGenomes-Tr:CAB11811" /db_xref="InterPro:IPR000305" /db_xref="InterPro:IPR035901" /db_xref="SubtiList:BG12700" /db_xref="UniProtKB/Swiss-Prot:O31414" /translation="METNNHFFYVVKCKDNSWYAGYTNDLHKRVKTHNDGKGAKYTKV RRPVELIFAESFSTKREAMQAEYYFKKLTRKKKELYIEEKRNSKEAVYVKAPNEL*" /label="yazA CDS" gene 43238..43537 /gene="yazA" /locus_tag="BSU_00350" /old_locus_tag="BSU00350" /label="yazA gene" CDS 43512..44390 /gene="rsmI" /locus_tag="BSU_00360" /old_locus_tag="BSU00360" /EC_number="2.1.1.198" /function="16.8: Protect" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16014871, 19965768, 25893373; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="16S rRNA 2'-O-ribose C1402 methyltransferase" /protein_id="NP_387917.1" /db_xref="EnsemblGenomes-Gn:BSU00360" /db_xref="EnsemblGenomes-Tr:CAB11812" /db_xref="GOA:P37544" /db_xref="InterPro:IPR000878" /db_xref="InterPro:IPR008189" /db_xref="InterPro:IPR014776" /db_xref="InterPro:IPR014777" /db_xref="InterPro:IPR018063" /db_xref="InterPro:IPR035996" /db_xref="SubtiList:BG10099" /db_xref="UniProtKB/Swiss-Prot:P37544" /translation="MLRRQMSFNGKSDMGILYLVPTPIGNLEDMTFRAIDTLKSVDAI AAEDTRQTKKLCHVYEIETPLVSYHEHNKESSGHKIIEWLKSGKNIALVSDAGLPTIS DPGAEIVKDFTDIGGYVVPLPGANAALTALIASGIVPQPFFFYGFLNRQKKEKKKELE ALKKRQETIIFYEAPHRLKETLSAMAEILGDREIAVTRELTKKYEEFIRGTISEVIGW ANEDQIRGEFCLVVEGSNNEEVDEEEQWWETLTAKEHVEHYISKGATSKEAIKKAAVD RNVPKREVYDAYHIKQ*" /label="rsmI CDS" gene 43512..44390 /gene="rsmI" /locus_tag="BSU_00360" /old_locus_tag="BSU00360" /label="rsmI gene" downshifts 44363 /Source="Nicolas_upshifts" /id="D13" /incds=0 /nref=23 /ntot=177 /MaxReadThrough="3.33195" /MaxDrop="3.72723" /score="5.97354542" /energy="-10.2" /TU="U29,U31" /idTUdmin="U29" /TUdmin="-23" /isTUend="FALSE" /label="downshifts" CDS complement(44439..44729) /gene="abrB" /locus_tag="BSU_00370" /old_locus_tag="BSU00370" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10754235, 10809710, 11101881, 11101897, 16159768, 16223496, 16702211, 25308864, 25381239, 18676675, 22183144, 23196984, 24832089, 24847778, 25288929" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10754235, 10809710, 11101881, 11101897, 16159768, 16223496, 16702211, 25308864, 25381239, 18676675, 22183144, 23196984, 24832089, 24847778, 25288929; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator for transition state genes (AbrB-SurF)" /protein_id="NP_387918.1" /db_xref="EnsemblGenomes-Gn:BSU00370" /db_xref="EnsemblGenomes-Tr:CAB11813" /db_xref="GOA:P08874" /db_xref="InterPro:IPR007159" /db_xref="PDB:1YFB" /db_xref="PDB:1YSF" /db_xref="PDB:1Z0R" /db_xref="PDB:2K1N" /db_xref="PDB:2MJG" /db_xref="PDB:2RO4" /db_xref="SubtiList:BG10100" /db_xref="UniProtKB/Swiss-Prot:P08874" /translation="MFMKSTGIVRKVDELGRVVIPIELRRTLGIAEKDALEIYVDDEK IILKKYKPNMTCQVTGEVSDDNLKLAGGKLVLSKEGAEQIISEIQNQLQNLK*" /label="abrB CDS" gene complement(44439..44729) /gene="abrB" /locus_tag="BSU_00370" /old_locus_tag="BSU00370" /label="abrB gene" downshifts complement(44441) /Source="Nicolas_upshifts" /id="D14" /incds=0 /nref=216 /ntot=263 /MaxReadThrough="2.17237" /MaxDrop="7.75729" /score="20.9582436" /energy="-10.2" /TU="U32" /idTUdmin="U32" /TUdmin="-23" /isTUend="FALSE" /label="downshifts" downshifts 44760 /Source="Nicolas_upshifts" /id="D15" /incds=0 /nref=1 /ntot=15 /MaxReadThrough="2.53543" /MaxDrop="4.31699" /score="13.7153159" /energy="-14.4" /TU="NA" /idTUdmin="U29" /TUdmin=374 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(44796..44815) /Source="Nicolas_upshift_promotors" /id="U32" /multdbtbs="SigA,SigA" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=2122 /SigmaFactorBS="tataagaactaattcttacaatcaatagtaaacaaaaTGATT GACgattattggaaacCTTGTTATGCTATGAAGGTAaggattttgtcgaataatgacg a" /listShort="abrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(44813) /Source="Nicolas_upshifts" /id="U32" /multdbtbs="SigA,SigA" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=2122 /SigmaFactorBS="tataagaactaattcttacaatcaatagtaaacaaaaTGATT GACgattattggaaacCTTGTTATGCTATGAAGGTAaggattttgtcgaataatgacg a" /listShort="abrB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(44815..44990) /Source="Nicolas_S_feature" /locus_tag="new_45224_45399_c" /HighExp="C30, H2O2, G180, Etha, S0, GM 25, Gly, G135, MG 25, MG-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S23" promotor_-35 complement(44829..44836) /Source="Nicolas_upshift_promotors" /id="U32" /multdbtbs="SigA,SigA" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=2122 /SigmaFactorBS="tataagaactaattcttacaatcaatagtaaacaaaaTGATT GACgattattggaaacCTTGTTATGCTATGAAGGTAaggattttgtcgaataatgacg a" /listShort="abrB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(44986..45005) /Source="Nicolas_upshift_promotors" /id="U33" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.603396603396603" /psig="0.993006993006993" /xcortree=2123 /SigmaFactorBS="aaatctttaatgaaaataaaaaaaGTCTGTTCgtgtcgaatt ttgTCGTATATAATCAAATGAAAtaaaaaactttggttcgaaagtcttgatttaaaag g" /listShort="S23" /listLong="abrB" /label="promotor_-10" upshifts complement(44990) /Source="Nicolas_upshifts" /id="U33" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.603396603396603" /psig="0.993006993006993" /xcortree=2123 /SigmaFactorBS="aaatctttaatgaaaataaaaaaaGTCTGTTCgtgtcgaatt ttgTCGTATATAATCAAATGAAAtaaaaaactttggttcgaaagtcttgatttaaaag g" /listShort="S23" /listLong="abrB" /label="upshifts" promotor_-35 complement(45019..45026) /Source="Nicolas_upshift_promotors" /id="U33" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.603396603396603" /psig="0.993006993006993" /xcortree=2123 /SigmaFactorBS="aaatctttaatgaaaataaaaaaaGTCTGTTCgtgtcgaatt ttgTCGTATATAATCAAATGAAAtaaaaaactttggttcgaaagtcttgatttaaaag g" /listShort="S23" /listLong="abrB" /label="promotor_-35" promotor_-35 45090..45094 /Source="Nicolas_upshift_promotors" /id="U34" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.803196803196803" /psig="0.999000999001" /xcortree=2569 /SigmaFactorBS="ttttaattattctttttcagggcgtatgtatatatTCTTGat cttaaaggctaaGATGGTATCATAGATAAAGGataaatataaataatattcatatatg a" /listShort="S24, metS, yabD, S26, yabE" /listLong="S27, rnmV, ksgA" /label="promotor_-35" promotor_-10 45109..45128 /Source="Nicolas_upshift_promotors" /id="U34" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.803196803196803" /psig="0.999000999001" /xcortree=2569 /SigmaFactorBS="ttttaattattctttttcagggcgtatgtatatatTCTTGat cttaaaggctaaGATGGTATCATAGATAAAGGataaatataaataatattcatatatg a" /listShort="S24, metS, yabD, S26, yabE" /listLong="S27, rnmV, ksgA" /label="promotor_-10" S_feature 45115..45223 /Source="Nicolas_S_feature" /locus_tag="new_45524_45632" /HighExp="LBGtran, Heat, dia5, dia15, LBGexp, Lbexp, dia0, H2O2, Diami, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S24" upshifts 45115 /Source="Nicolas_upshifts" /id="U34" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.803196803196803" /psig="0.999000999001" /xcortree=2569 /SigmaFactorBS="ttttaattattctttttcagggcgtatgtatatatTCTTGat cttaaaggctaaGATGGTATCATAGATAAAGGataaatataaataatattcatatatg a" /listShort="S24, metS, yabD, S26, yabE" /listLong="S27, rnmV, ksgA" /label="upshifts" CDS 45224..47218 /gene="metS" /locus_tag="BSU_00380" /old_locus_tag="BSU00380" /EC_number="6.1.1.10" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11233169, 12682299, 12792655; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methionyl-tRNA synthetase" /protein_id="NP_387919.1" /db_xref="EnsemblGenomes-Gn:BSU00380" /db_xref="EnsemblGenomes-Tr:CAB11814" /db_xref="GOA:P37465" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR002547" /db_xref="InterPro:IPR004495" /db_xref="InterPro:IPR009080" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR013155" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR014758" /db_xref="InterPro:IPR015413" /db_xref="InterPro:IPR023457" /db_xref="InterPro:IPR033911" /db_xref="SubtiList:BG10101" /db_xref="UniProtKB/Swiss-Prot:P37465" /translation="MPQENNTFYITTPIYYPSGKLHIGHAYTTVAGDAMARYKRLKGF DVRYLTGTDEHGQKIQQKAEQENITPQEYVDRAAADIQKLWKQLEISNDDFIRTTEKR HKVVIEKVFQKLLDNGDIYLDEYEGWYSIPDETFYTETQLVDIERNEKGEVIGGKSPD SGHPVELIKEESYFFRMGKYADRLLKYYEENPTFIQPESRKNEMINNFIKPGLEDLAV SRTTFDWGVKVPENPKHVVYVWIDALFNYLTALGYDTENDELYQKYWPADVHLVGKEI VRFHTIYWPIMLMALDLPLPKQVFAHGWLLMKDGKMSKSKGNVVDPVTLIERYGLDEL RYYLLREVPFGSDGVFTPEGFVERINYDLANDLGNLLNRTVAMINKYFDGQIGSYKGA VTEFDHTLTSVAEETVKAYEKAMENMEFSVALSTLWQLISRTNKYIDETAPWVLAKDP AKEEELRSVMYHLAESLRISAVLLQPFLTKTPEKMFEQLGITDESLKAWDSITAFGQL KDTKVQKGEPLFPRLEAEEEIAYIKGKMQGSAPAKEETKEEEPQEVDRLPEITIDQFM DVELRVAEVIEAEPVKKADRLLKLQLDLGFEKRQVVSGIAKHYTPEELVGKKLVCVTN LKPVKLRGELSQGMILAGEADGVLKVVSIDQSLPKGTRIK*" /label="metS CDS" gene 45224..47218 /gene="metS" /locus_tag="BSU_00380" /old_locus_tag="BSU00380" /label="metS gene" promotor_-10 complement(45972..45991) /Source="Nicolas_upshift_promotors" /id="U35" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1824 /SigmaFactorBS="cgactaaatgaacatcggcaggccaatatTTTTGataaagct catcattTTCTGTATCATAACCGAGTGccgttaaatagttaaatagtgcgtcaatcca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(45980) /Source="Nicolas_upshifts" /id="U35" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1824 /SigmaFactorBS="cgactaaatgaacatcggcaggccaatatTTTTGataaagct catcattTTCTGTATCATAACCGAGTGccgttaaatagttaaatagtgcgtcaatcca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(46007..46011) /Source="Nicolas_upshift_promotors" /id="U35" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1824 /SigmaFactorBS="cgactaaatgaacatcggcaggccaatatTTTTGataaagct catcattTTCTGTATCATAACCGAGTGccgttaaatagttaaatagtgcgtcaatcca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 47202 /Source="Nicolas_upshifts" /id="D16" /incds=0 /nref=18 /ntot=206 /MaxReadThrough="4.8491" /MaxDrop="2.9167" /score="13.7153159" /energy="-14.4" /TU="U34" /idTUdmin="U34" /TUdmin="-2288" /isTUend="FALSE" /label="downshifts" S_feature complement(47264..49610) /Source="Nicolas_S_feature" /locus_tag="new_47673_50019_c" /HighExp="T0.30H, T1.0H, T1.30H, Salt, C30, T2.0H, T-0.40H, T0.0H, T2.30H, T-1.10H" /AntisenseName="yabE" /AntisenseCor="-0.28154713646185298" /AntisenseRegPval="-5.6" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S25" CDS 47297..48064 /gene="dayD" /locus_tag="BSU_00390" /old_locus_tag="BSU00390" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10747959, 16014871, 16461678, 19332551; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-amino acyl-tRNA deacylase" /protein_id="NP_387920.1" /db_xref="EnsemblGenomes-Gn:BSU00390" /db_xref="EnsemblGenomes-Tr:CAB11815" /db_xref="GOA:P37545" /db_xref="InterPro:IPR001130" /db_xref="InterPro:IPR015991" /db_xref="InterPro:IPR018228" /db_xref="InterPro:IPR032466" /db_xref="SubtiList:BG10102" /db_xref="UniProtKB/Swiss-Prot:P37545" /translation="MLFDTHAHLNAEQYDTDLEEVIERAKAEKVERIVVVGFDRPTIT RAMEMIEEYDFIYAAIGWHPVDAIDMTEEDLAWIKELSAHEKVVAIGEMGLDYHWDKS PKDIQKEVFRNQIALAKEVNLPIIIHNRDATEDVVTILKEEGAEAVGGIMHCFTGSAE VARECMKMNFYLSFGGPVTFKNAKKPKEVVKEIPNDRLLIETDCPFLTPHPFRGKRNE PSYVKYVAEQIAELKEMTFEEIASITTENAKRLFRIN*" /label="dayD CDS" gene 47297..48064 /gene="dayD" /locus_tag="BSU_00390" /old_locus_tag="BSU00390" /label="dayD gene" S_feature 48065..48145 /Source="Nicolas_S_feature" /locus_tag="new_48474_48554" /HighExp="Heat, C30, LBGtran, LBGstat, C90, Etha, M40t45, LPhT, MG 15, Gly" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S26" promotor_-35 48122..48127 /Source="Nicolas_upshift_promotors" /id="U36" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.943056943056943" /psig="0.943056943056943" /xcortree=438 /SigmaFactorBS="taagagcttgtcccttacagcgtttttctataaaaGTTCTAc atgctttcttctccTCATAGGATAGGTTTGTCGacaagtctttcttccgtttctcagt g" /listShort="yabE, S27, rnmV, ksgA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 48143..48161 /Source="Nicolas_upshift_promotors" /id="U36" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.943056943056943" /psig="0.943056943056943" /xcortree=438 /SigmaFactorBS="taagagcttgtcccttacagcgtttttctataaaaGTTCTAc atgctttcttctccTCATAGGATAGGTTTGTCGacaagtctttcttccgtttctcagt g" /listShort="yabE, S27, rnmV, ksgA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 48147 /Source="Nicolas_upshifts" /id="U36" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.943056943056943" /psig="0.943056943056943" /xcortree=438 /SigmaFactorBS="taagagcttgtcccttacagcgtttttctataaaaGTTCTAc atgctttcttctccTCATAGGATAGGTTTGTCGacaagtctttcttccgtttctcagt g" /listShort="yabE, S27, rnmV, ksgA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 48172..48175 /Source="Nicolas_upshift_promotors" /id="U37" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.705294705294705" /psig="0.843156843156843" /xcortree=440 /SigmaFactorBS="aggataggtttgtcgacaagtctttCTTCcgtttctcagtgt aTTTCAGGATAATGAAGAGGAcactgagcttttgggagaaagagaagggagggttgac a" /listShort="yabE, S27" /listLong="rnmV, ksgA" /label="promotor_-35" promotor_-10 48190..48209 /Source="Nicolas_upshift_promotors" /id="U37" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.705294705294705" /psig="0.843156843156843" /xcortree=440 /SigmaFactorBS="aggataggtttgtcgacaagtctttCTTCcgtttctcagtgt aTTTCAGGATAATGAAGAGGAcactgagcttttgggagaaagagaagggagggttgac a" /listShort="yabE, S27" /listLong="rnmV, ksgA" /label="promotor_-10" upshifts 48207 /Source="Nicolas_upshifts" /id="U37" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.705294705294705" /psig="0.843156843156843" /xcortree=440 /SigmaFactorBS="aggataggtttgtcgacaagtctttCTTCcgtttctcagtgt aTTTCAGGATAATGAAGAGGAcactgagcttttgggagaaagagaagggagggttgac a" /listShort="yabE, S27" /listLong="rnmV, ksgA" /label="upshifts" CDS 48220..49533 /gene="yabE" /locus_tag="BSU_00400" /old_locus_tag="BSU00400" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15774001, 19047346; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative cell wall shaping enzyme" /protein_id="NP_387921.1" /db_xref="EnsemblGenomes-Gn:BSU00400" /db_xref="EnsemblGenomes-Tr:CAB11816" /db_xref="GOA:P37546" /db_xref="InterPro:IPR007137" /db_xref="InterPro:IPR010611" /db_xref="InterPro:IPR011098" /db_xref="InterPro:IPR036908" /db_xref="SubtiList:BG10103" /db_xref="UniProtKB/Swiss-Prot:P37546" /translation="MGEREGRVDSLLDTLYNLSEEKEAFFITQKMKKLFSVKLSKSKV ILVAACLLLAGSGTAYAAHELTKQSVSVSINGKKKHIRTHANTVGDLLETLDIKTRDE DKITPAKQTKITADMDVVYEAAKPVKLTINGEEKTLWSTAKTVGALLDEQDVDVKEQD QIDPAIDTDISKDMKINIEPAFQVTVNDAGKQKKIWTTSTTVADFLKQQKMNIKDEDK IKPALDAKLTKGKADITITRIEKVTDVVEEKIAFDVKKQEDASLEKGKEKVVQKGKEG KLKKHFEVVKENGKEVSRELVKEETAEQSKDKVIAVGTKQSSPKFETVSASGDSKTVV SRSNESTGKVMTVSSTAYTASCSGCSGHTATGVNLKNNPNAKVIAVDPNVIPLGSKVH VEGYGYAIAADTGSAIKGNKIDVFFPEKSSAYRWGNKTVKIKILN*" /label="yabE CDS" gene 48220..49533 /gene="yabE" /locus_tag="BSU_00400" /old_locus_tag="BSU00400" /label="yabE gene" promotor_-35 48240..48247 /Source="Nicolas_upshift_promotors" /id="U38" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.926073926073926" /psig=1 /xcortree=2420 /SigmaFactorBS="taatgaagaggacactgagcttttgggagaaagagaagggag GGTTGACAgccttttagatactCTATATAATCTCTCCGAGGAgaaggaggcgtttttc a" /listShort="yabE, S27, rnmV, ksgA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 48258 /Source="Nicolas_upshifts" /id="U38" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.926073926073926" /psig=1 /xcortree=2420 /SigmaFactorBS="taatgaagaggacactgagcttttgggagaaagagaagggag GGTTGACAgccttttagatactCTATATAATCTCTCCGAGGAgaaggaggcgtttttc a" /listShort="yabE, S27, rnmV, ksgA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 48262..48281 /Source="Nicolas_upshift_promotors" /id="U38" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.926073926073926" /psig=1 /xcortree=2420 /SigmaFactorBS="taatgaagaggacactgagcttttgggagaaagagaagggag GGTTGACAgccttttagatactCTATATAATCTCTCCGAGGAgaaggaggcgtttttc a" /listShort="yabE, S27, rnmV, ksgA" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 49494 /Source="Nicolas_upshifts" /id="D17" /incds=0 /nref=87 /ntot=220 /MaxReadThrough="5.02755" /MaxDrop="4.87493" /score="27.529638" /energy="-11.3" /TU="U36,U37,U38" /idTUdmin="U34" /TUdmin=4 /isTUend="TRUE" /label="downshifts" promotor_-35 49556..49560 /Source="Nicolas_upshift_promotors" /id="U39" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.928071928071928" /psig=1 /xcortree=2584 /SigmaFactorBS="taaaatcttaaattagtatatacttatgtattcagaggGTTT TgcgccctctgtttttTTCGTTATAATAGACAAAGTgcattttctgcttattagacgc t" /listShort="S27, rnmV, ksgA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 49576..49595 /Source="Nicolas_upshift_promotors" /id="U39" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.928071928071928" /psig=1 /xcortree=2584 /SigmaFactorBS="taaaatcttaaattagtatatacttatgtattcagaggGTTT TgcgccctctgtttttTTCGTTATAATAGACAAAGTgcattttctgcttattagacgc t" /listShort="S27, rnmV, ksgA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 49578..49677 /Source="Nicolas_S_feature" /locus_tag="new_49987_50086" /HighExp="LoTm, H2O2, G180, G135, G150, Paraq, Oxctl, C30, dia15, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigEF" /TUshortPSig="1, 1, 0.843, 0.943" /TUlongSig="SigA" /TUlongPSig="0.999" /label="S27" upshifts 49578 /Source="Nicolas_upshifts" /id="U39" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.928071928071928" /psig=1 /xcortree=2584 /SigmaFactorBS="taaaatcttaaattagtatatacttatgtattcagaggGTTT TgcgccctctgtttttTTCGTTATAATAGACAAAGTgcattttctgcttattagacgc t" /listShort="S27, rnmV, ksgA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(49602..49617) /Source="Nicolas_upshift_promotors" /id="U40" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2365 /SigmaFactorBS="ttatttcctccaagacaaaataaaaacttttgtatattcaTG AAACTTTTtcttatatcgaGCGTCTAATAAGCAGAaaatgcactttgtctattataac g" /listShort="S25" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(49618) /Source="Nicolas_upshifts" /id="U40" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2365 /SigmaFactorBS="ttatttcctccaagacaaaataaaaacttttgtatattcaTG AAACTTTTtcttatatcgaGCGTCTAATAAGCAGAaaatgcactttgtctattataac g" /listShort="S25" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(49629..49638) /Source="Nicolas_upshift_promotors" /id="U40" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2365 /SigmaFactorBS="ttatttcctccaagacaaaataaaaacttttgtatattcaTG AAACTTTTtcttatatcgaGCGTCTAATAAGCAGAaaatgcactttgtctattataac g" /listShort="S25" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 49674..49690 /Source="Nicolas_upshift_promotors" /id="U41" /multdbtbs="-" /comp="M11" /sig="Sig-" /pcomp="0.48051948051948" /psig="0.48051948051948" /xcortree=100 /SigmaFactorBS="aaaaagtttcatgaatatacaaaagtttttattttgtcttgg aggaAATAATGAAAATTAAAGagatcattgtggtcgaggggcgtgacgatacggcccg c" /listShort="rnmV, ksgA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 49678..50238 /gene="rnmV" /locus_tag="BSU_00410" /old_locus_tag="BSU00410" /EC_number="3.1.26.8" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11233981, 11976317, 12794188, 16077031" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11233981, 11976317, 12794188, 16077031; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease M5" /protein_id="NP_387922.1" /db_xref="EnsemblGenomes-Gn:BSU00410" /db_xref="EnsemblGenomes-Tr:CAB11817" /db_xref="GOA:P37547" /db_xref="InterPro:IPR004466" /db_xref="InterPro:IPR006171" /db_xref="InterPro:IPR025156" /db_xref="InterPro:IPR034141" /db_xref="SubtiList:BG10104" /db_xref="UniProtKB/Swiss-Prot:P37547" /translation="MKIKEIIVVEGRDDTARIKLAVDADTIETNGSAIDDHVIDQIRL AQKTRGVIILTDPDFPGEKIRKTISEAVPGCKHAFLPKHLAKPKNKRGIGVEHASVES IRACLENVHEEMEAQPSDISAEDLIHAGLIGGPAAKCRRERLGDLLKIGYTNGKQLQK RLQMFQIKKSDFMSALDTVMREEQNE*" /label="rnmV CDS" gene 49678..50238 /gene="rnmV" /locus_tag="BSU_00410" /old_locus_tag="BSU00410" /label="rnmV gene" upshifts 49688 /Source="Nicolas_upshifts" /id="U41" /multdbtbs="-" /comp="M11" /sig="Sig-" /pcomp="0.48051948051948" /psig="0.48051948051948" /xcortree=100 /SigmaFactorBS="aaaaagtttcatgaatatacaaaagtttttattttgtcttgg aggaAATAATGAAAATTAAAGagatcattgtggtcgaggggcgtgacgatacggcccg c" /listShort="rnmV, ksgA" /GFF_Attribute="listLong" /label="upshifts" CDS 50231..51109 /gene="rsmA" /locus_tag="BSU_00420" /old_locus_tag="BSU00420" /EC_number="2.1.1.-" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 99430, 6801425, 11327780, 1690648, 22391551; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dimethyladenosine 16S ribosomal RNA transferase" /protein_id="NP_387923.1" /db_xref="EnsemblGenomes-Gn:BSU00420" /db_xref="EnsemblGenomes-Tr:CAB11818" /db_xref="GOA:P37468" /db_xref="InterPro:IPR001737" /db_xref="InterPro:IPR011530" /db_xref="InterPro:IPR020596" /db_xref="InterPro:IPR020598" /db_xref="InterPro:IPR023165" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG10105" /db_xref="UniProtKB/Swiss-Prot:P37468" /translation="MNKDIATPIRTKEILKKYGFSFKKSLGQNFLIDTNILNRIVDHA EVTEKTGVIEIGPGIGALTEQLAKRAKKVVAFEIDQRLLPILKDTLSPYENVTVIHQD VLKADVKSVIEEQFQDCDEIMVVANLPYYVTTPIIMKLLEEHLPLKGIVVMLQKEVAE RMAADPSSKEYGSLSIAVQFYTEAKTVMIVPKTVFVPQPNVDSAVIRLILRDGPAVDV ENESFFFQLIKASFAQRRKTLLNNLVNNLPEGKAQKSTIEQVLEETNIDGKRRGESLS IEEFAALSNGLYKALF*" /label="rsmA CDS" gene 50231..51109 /gene="rsmA" /locus_tag="BSU_00420" /old_locus_tag="BSU00420" /label="rsmA gene" downshifts 51074 /Source="Nicolas_upshifts" /id="D18" /incds=0 /nref=152 /ntot=229 /MaxReadThrough="3.0815" /MaxDrop="4.58632" /score="20.4155562" /energy="-9.4" /TU="NA" /idTUdmin="U36" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 51124..51133 /Source="Nicolas_upshift_promotors" /id="U42" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1303 /SigmaFactorBS="ttgtataaagcccttttctaaaagggctttttgttTTGCGCA CCAcatggactgccgcTACATAGGCTAGAGAAGGACctttcattcaatgataagaaaa a" /listShort="S28, yabG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 51147..51166 /Source="Nicolas_upshift_promotors" /id="U42" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1303 /SigmaFactorBS="ttgtataaagcccttttctaaaagggctttttgttTTGCGCA CCAcatggactgccgcTACATAGGCTAGAGAAGGACctttcattcaatgataagaaaa a" /listShort="S28, yabG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 51149..51270 /Source="Nicolas_S_feature" /locus_tag="new_51558_51679" /HighExp="S7, S6, S8, BT, S5, B36, G/S, Pyr, B60, Etha" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S28" upshifts 51149 /Source="Nicolas_upshifts" /id="U42" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1303 /SigmaFactorBS="ttgtataaagcccttttctaaaagggctttttgttTTGCGCA CCAcatggactgccgcTACATAGGCTAGAGAAGGACctttcattcaatgataagaaaa a" /listShort="S28, yabG" /GFF_Attribute="listLong" /label="upshifts" CDS 51271..52143 /gene="prtG" /locus_tag="BSU_00430" /old_locus_tag="BSU00430" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10714992, 11040425, 16751597, 19060142, 19833771" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10714992, 11040425, 16751597, 19060142, 19833771; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="sporulation-specific protease" /protein_id="NP_387924.1" /db_xref="EnsemblGenomes-Gn:BSU00430" /db_xref="EnsemblGenomes-Tr:CAB11819" /db_xref="GOA:P37548" /db_xref="InterPro:IPR008764" /db_xref="SubtiList:BG10106" /db_xref="UniProtKB/Swiss-Prot:P37548" /translation="MQFQIGDMVARKSYQMDVLFRIIGIEQTSKGNSIAILHGDEVRL IADSDFSDLVAVKKDEQMMRKKKDESRMNESLELLRQDYKLLREKQEYYATSQYQHQE HYFHMPGKVLHLDGDEAYLKKCLNVYKKIGVPVYGIHCHEKKMSASIEVLLDKYRPDI LVITGHDAYSKQKGGIDDLNAYRHSKHFVETVQTARKKIPHLDQLVIFAGACQSHFES LIRAGANFASSPSRVNIHALDPVYIVAKISFTPFMERINVWEVLRNTLTREKGLGGIE TRGVLRIGMPYKSN*" /label="prtG CDS" gene 51271..52143 /gene="prtG" /locus_tag="BSU_00430" /old_locus_tag="BSU00430" /label="prtG gene" downshifts 52130 /Source="Nicolas_upshifts" /id="D19" /incds=0 /nref=15 /ntot=32 /MaxReadThrough="2.30424" /MaxDrop="7.1507" /score="26.6672651" /energy="-11.5" /TU="NA" /idTUdmin="U42" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 52240..52310 /Source="Nicolas_S_feature" /locus_tag="new_52649_52719" /HighExp="S8, S5, S7, S6, S4, BT, LoTm, G/S, nit, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S29" promotor_-35 52301..52308 /Source="Nicolas_upshift_promotors" /id="U43" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3089 /SigmaFactorBS="aaataattttattgacaacgtcttattaacgttgatataatt taaatttTATTTGACaaaaatgggctcgTGTTGTACAATAAATGTAGTgaggtggatg c" /listShort="veg, S30, sspF" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 52312 /Source="Nicolas_upshifts" /id="U43" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3089 /SigmaFactorBS="aaataattttattgacaacgtcttattaacgttgatataatt taaatttTATTTGACaaaaatgggctcgTGTTGTACAATAAATGTAGTgaggtggatg c" /listShort="veg, S30, sspF" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 52322..52341 /Source="Nicolas_upshift_promotors" /id="U43" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3089 /SigmaFactorBS="aaataattttattgacaacgtcttattaacgttgatataatt taaatttTATTTGACaaaaatgggctcgTGTTGTACAATAAATGTAGTgaggtggatg c" /listShort="veg, S30, sspF" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(52331..52345) /Source="Nicolas_upshift_promotors" /id="U44" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.996003996003996" /psig="0.000999000999001" /xcortree=718 /SigmaFactorBS="attcccatcaagcgatcttttaatatcggacaacgtcttcGC CATtgcatccaCCTCACTACATTTATtgtacaacacgagcccatttttgtcaaataaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(52338) /Source="Nicolas_upshifts" /id="U44" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.996003996003996" /psig="0.000999000999001" /xcortree=718 /SigmaFactorBS="attcccatcaagcgatcttttaatatcggacaacgtcttcGC CATtgcatccaCCTCACTACATTTATtgtacaacacgagcccatttttgtcaaataaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(52354..52358) /Source="Nicolas_upshift_promotors" /id="U44" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.996003996003996" /psig="0.000999000999001" /xcortree=718 /SigmaFactorBS="attcccatcaagcgatcttttaatatcggacaacgtcttcGC CATtgcatccaCCTCACTACATTTATtgtacaacacgagcccatttttgtcaaataaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 52354..52614 /gene="veg" /locus_tag="BSU_00440" /old_locus_tag="BSU00440" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12761295, 22720735, 23378512; Producttype ph: phenotype" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_387925.1" /db_xref="EnsemblGenomes-Gn:BSU00440" /db_xref="EnsemblGenomes-Tr:CAB11820" /db_xref="GOA:P37466" /db_xref="InterPro:IPR009366" /db_xref="SubtiList:BG10107" /db_xref="UniProtKB/Swiss-Prot:P37466" /translation="MAKTLSDIKRSLDGNLGKRLTLKANGGRRKTIERSGILAETYPS VFVIQLDQDENSFERVSYSYADILTETVELTFNDDAASSVAF*" /label="veg CDS" gene 52354..52614 /gene="veg" /locus_tag="BSU_00440" /old_locus_tag="BSU00440" /label="veg gene" downshifts 52526 /Source="Nicolas_upshifts" /id="D20" /incds=1 /nref=4 /ntot=158 /MaxReadThrough="8.09861" /MaxDrop="2.7867" /score="12.4853319" /energy="-9.9" /TU="U43" /idTUdmin="U42" /TUdmin=396 /isTUend="FALSE" /label="downshifts" downshifts 52613 /Source="Nicolas_upshifts" /id="D21" /incds=0 /nref=191 /ntot=264 /MaxReadThrough="5.88511" /MaxDrop="6.03144" /score="12.4853319" /energy="-9.9" /TU="U43" /idTUdmin="U43" /TUdmin="-331" /isTUend="FALSE" /label="downshifts" promotor_-35 52679..52685 /Source="Nicolas_upshift_promotors" /id="U45" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=844 /SigmaFactorBS="ttttgttttgcccttttttggtttccaataattttaaCGAAA GTtccatctgatttaACAAAAGATAAAacagtcacatattatcgtgacgtgcacgaat g" /listShort="S30, sspF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 52699..52710 /Source="Nicolas_upshift_promotors" /id="U45" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=844 /SigmaFactorBS="ttttgttttgcccttttttggtttccaataattttaaCGAAA GTtccatctgatttaACAAAAGATAAAacagtcacatattatcgtgacgtgcacgaat g" /listShort="S30, sspF" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 52702..52773 /Source="Nicolas_S_feature" /locus_tag="new_53111_53182" /HighExp="S8, Cold, S6, S7, ferm, S5, nit, Etha, G135, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigA" /TUshortPSig="0.96, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S30" upshifts 52702 /Source="Nicolas_upshifts" /id="U45" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=844 /SigmaFactorBS="ttttgttttgcccttttttggtttccaataattttaaCGAAA GTtccatctgatttaACAAAAGATAAAacagtcacatattatcgtgacgtgcacgaat g" /listShort="S30, sspF" /GFF_Attribute="listLong" /label="upshifts" CDS 52774..52959 /gene="sspF" /locus_tag="BSU_00450" /old_locus_tag="BSU00450" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7959056, 8982008, 11092849" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7959056, 8982008, 11092849; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein (alpha/beta-type SASP)" /protein_id="NP_387926.1" /db_xref="EnsemblGenomes-Gn:BSU00450" /db_xref="EnsemblGenomes-Tr:CAB11821" /db_xref="GOA:P37549" /db_xref="InterPro:IPR001448" /db_xref="InterPro:IPR018126" /db_xref="SubtiList:BG10108" /db_xref="UniProtKB/Swiss-Prot:P37549" /translation="MGRRRGVMSDEFKYELAKDLGFYDTVKNGGWGEIRARDAGNMVK RAIEIAEQQMAQNQNNR*" /label="sspF CDS" gene 52774..52959 /gene="sspF" /locus_tag="BSU_00450" /old_locus_tag="BSU00450" /label="sspF gene" downshifts 52944 /Source="Nicolas_upshifts" /id="D22" /incds=0 /nref=54 /ntot=153 /MaxReadThrough="2.67408" /MaxDrop="6.21058" /score="38.1065567" /energy="-12.6" /TU="NA" /idTUdmin="U43" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(52954..55308) /Source="Nicolas_S_feature" /locus_tag="new_53363_55717_c" /HighExp="S5, S4, S6, T5.0H, S3, S8, S7, T4.0H, T3.30H, C30" /AntisenseName="ispE" /AntisenseCor="-0.66604185700913698" /AntisenseRegPval="-35.1" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S31" promotor_-35 53037..53041 /Source="Nicolas_upshift_promotors" /id="U46" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.745254745254745" /psig=1 /xcortree=2586 /SigmaFactorBS="ttttggatataaatacataatgggctgaatatggataTGTTC atcctgtacttcaaaTGTGATACAATGTTCATACTtatgtttagatggagaagtaggt g" /listShort="ispE, purR, yabJ, S32" /listLong="spoVG" /label="promotor_-35" promotor_-10 53057..53076 /Source="Nicolas_upshift_promotors" /id="U46" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.745254745254745" /psig=1 /xcortree=2586 /SigmaFactorBS="ttttggatataaatacataatgggctgaatatggataTGTTC atcctgtacttcaaaTGTGATACAATGTTCATACTtatgtttagatggagaagtaggt g" /listShort="ispE, purR, yabJ, S32" /listLong="spoVG" /label="promotor_-10" upshifts 53060 /Source="Nicolas_upshifts" /id="U46" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.745254745254745" /psig=1 /xcortree=2586 /SigmaFactorBS="ttttggatataaatacataatgggctgaatatggataTGTTC atcctgtacttcaaaTGTGATACAATGTTCATACTtatgtttagatggagaagtaggt g" /listShort="ispE, purR, yabJ, S32" /listLong="spoVG" /label="upshifts" CDS 53107..53976 /gene="ispE" /locus_tag="BSU_00460" /old_locus_tag="BSU00460" /EC_number="2.7.1.148" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11361082, 12682299, 12771135, 17458547, 23840410; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase" /protein_id="NP_387927.1" /db_xref="EnsemblGenomes-Gn:BSU00460" /db_xref="EnsemblGenomes-Tr:CAB11822" /db_xref="GOA:P37550" /db_xref="InterPro:IPR004424" /db_xref="InterPro:IPR006204" /db_xref="InterPro:IPR013750" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR036554" /db_xref="SubtiList:BG10109" /db_xref="UniProtKB/Swiss-Prot:P37550" /translation="MRILEKAPAKINLSLDVTRKRPDGYHEVEMIMTTIDLADRIELT ELAEDEVRVSSHNRFVPDDQRNLAYQAAKLIKDRYNVKKGVSIMITKVIPVAAGLAGG SSDAAATLRGLNRLWNLNLSAETLAELGAEIGSDVSFCVYGGTALATGRGEKIKHIST PPHCWVILAKPTIGVSTAEVYRALKLDGIEHPDVQGMIEAIEEKSFQKMCSRLGNVLE SVTLDMHPEVAMIKNQMKRFGADAVLMSGSGPTVFGLVQYESKVQRIYNGLRGFCDQV YAVRMIGEQNALD*" /label="ispE CDS" gene 53107..53976 /gene="ispE" /locus_tag="BSU_00460" /old_locus_tag="BSU00460" /label="ispE gene" CDS 54032..54889 /gene="purR" /locus_tag="BSU_00470" /old_locus_tag="BSU00470" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11591660, 12837783, 12837784, 15629952, 16163456, 27329548" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11591660, 12837783, 12837784, 15629952, 16163456, 27329548; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of the purine biosynthesis operon (PurR-pRpp)" /protein_id="NP_387928.1" /db_xref="EnsemblGenomes-Gn:BSU00470" /db_xref="EnsemblGenomes-Tr:CAB11823" /db_xref="GOA:P37551" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR010078" /db_xref="InterPro:IPR015265" /db_xref="InterPro:IPR029057" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:1O57" /db_xref="PDB:1P4A" /db_xref="SubtiList:BG10110" /db_xref="UniProtKB/Swiss-Prot:P37551" /translation="MKFRRSGRLVDLTNYLLTHPHELIPLTFFSERYESAKSSISEDL TIIKQTFEQQGIGTLLTVPGAAGGVKYIPKMKQAEAEEFVQTLGQSLANPERILPGGY VYLTDILGKPSVLSKVGKLFASVFAEREIDVVMTVATKGIPLAYAAASYLNVPVVIVR KDNKVTEGSTVSINYVSGSSNRIQTMSLAKRSMKTGSNVLIIDDFMKAGGTINGMINL LDEFNANVAGIGVLVEAEGVDERLVDEYMSLLTLSTINMKEKSIEIQNGNFLRFFKDN LLKNGETES*" /label="purR CDS" gene 54032..54889 /gene="purR" /locus_tag="BSU_00470" /old_locus_tag="BSU00470" /label="purR gene" CDS 54886..55263 /gene="ridA" /locus_tag="BSU_00480" /old_locus_tag="BSU00480" /EC_number="3.5.99.10" /function="16.6: Maintain" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2113912, 12515541, 14729707, 10557275, 10919400, 10368157, 20562306, 23815688; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aminoacrylate/iminopropionate hydrolase/deaminase" /protein_id="NP_387929.1" /db_xref="EnsemblGenomes-Gn:BSU00480" /db_xref="EnsemblGenomes-Tr:CAB11824" /db_xref="GOA:P37552" /db_xref="InterPro:IPR006056" /db_xref="InterPro:IPR006175" /db_xref="InterPro:IPR019897" /db_xref="InterPro:IPR035959" /db_xref="PDB:1QD9" /db_xref="SubtiList:BG10111" /db_xref="UniProtKB/Swiss-Prot:P37552" /translation="MTKAVHTKHAPAAIGPYSQGIIVNNMFYSSGQIPLTPSGEMVNG DIKEQTHQVFSNLKAVLEEAGASFETVVKATVFIADMEQFAEVNEVYGQYFDTHKPAR SCVEVARLPKDALVEIEVIALVK*" /label="ridA CDS" gene 54886..55263 /gene="ridA" /locus_tag="BSU_00480" /old_locus_tag="BSU00480" /label="ridA gene" downshifts 55253 /Source="Nicolas_upshifts" /id="D23" /incds=0 /nref=172 /ntot=226 /MaxReadThrough="3.8891" /MaxDrop="4.63425" /score="22.9159767" /energy="-12.3" /TU="U46" /idTUdmin="U46" /TUdmin="-155" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(55297..55315) /Source="Nicolas_upshift_promotors" /id="U47" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1146 /SigmaFactorBS="ttttgaaaaaataggatatagttacacaattagGTCATAaag ctttcatttcggGCATAAGGTAAATAAAAAAgtgatcccggctctcccagaatcactt t" /listShort="S31" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 55298..55406 /Source="Nicolas_S_feature" /locus_tag="new_55707_55815" /HighExp="S8, S7, Etha, B36, LoTm, C30, Sw, B60, G135, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S32" upshifts complement(55309) /Source="Nicolas_upshifts" /id="U47" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1146 /SigmaFactorBS="ttttgaaaaaataggatatagttacacaattagGTCATAaag ctttcatttcggGCATAAGGTAAATAAAAAAgtgatcccggctctcccagaatcactt t" /listShort="S31" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(55331..55336) /Source="Nicolas_upshift_promotors" /id="U47" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1146 /SigmaFactorBS="ttttgaaaaaataggatatagttacacaattagGTCATAaag ctttcatttcggGCATAAGGTAAATAAAAAAgtgatcccggctctcccagaatcactt t" /listShort="S31" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 55386..55394 /Source="Nicolas_upshift_promotors" /id="U48" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=524 /SigmaFactorBS="actatatcctattttttcaaaaaatattttaaaaacgaGCAG GATTTcagaaaaaatCGTGGAATTGATACACTAAtgcttttatatagggaaaaggtgg t" /listShort="spoVG, S33, gcaD, prs" /listLong="ctc, pth, yabK, S34, mfd, S35, spoVT" /label="promotor_-35" promotor_-10 55405..55423 /Source="Nicolas_upshift_promotors" /id="U48" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=524 /SigmaFactorBS="actatatcctattttttcaaaaaatattttaaaaacgaGCAG GATTTcagaaaaaatCGTGGAATTGATACACTAAtgcttttatatagggaaaaggtgg t" /listShort="spoVG, S33, gcaD, prs" /listLong="ctc, pth, yabK, S34, mfd, S35, spoVT" /label="promotor_-10" upshifts 55408 /Source="Nicolas_upshifts" /id="U48" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=524 /SigmaFactorBS="actatatcctattttttcaaaaaatattttaaaaacgaGCAG GATTTcagaaaaaatCGTGGAATTGATACACTAAtgcttttatatagggaaaaggtgg t" /listShort="spoVG, S33, gcaD, prs" /listLong="ctc, pth, yabK, S34, mfd, S35, spoVT" /label="upshifts" CDS 55457..55750 /gene="spoVG" /locus_tag="BSU_00490" /old_locus_tag="BSU00490" /function="16.3: Control" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:9733708, 10348850, 10648512, 16428420, 27048798" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9733708, 10348850, 10648512, 16428420, 27048798; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator required for spore cortex synthesis (stage V sporulation)" /protein_id="NP_387930.1" /db_xref="EnsemblGenomes-Gn:BSU00490" /db_xref="EnsemblGenomes-Tr:CAB11825" /db_xref="GOA:P28015" /db_xref="InterPro:IPR007170" /db_xref="InterPro:IPR036751" /db_xref="PDB:2IA9" /db_xref="SubtiList:BG10112" /db_xref="UniProtKB/Swiss-Prot:P28015" /translation="MEVTDVRLRRVNTDGRMRAIASITLDHEFVVHDIRVIDGNNGLF VAMPSKRTPDGEFRDITHPINSSTRGKIQDAVLNEYHRLGDTEALEFEEAGAS*" /label="spoVG CDS" gene 55457..55750 /gene="spoVG" /locus_tag="BSU_00490" /old_locus_tag="BSU00490" /label="spoVG gene" downshifts 55739 /Source="Nicolas_upshifts" /id="D24" /incds=0 /nref=263 /ntot=285 /MaxReadThrough="5.11673" /MaxDrop="7.2673" /score="19.392304" /energy="-22.3" /TU="U48" /idTUdmin="U46" /TUdmin=331 /isTUend="FALSE" /label="downshifts" S_feature 55784..55895 /Source="Nicolas_S_feature" /locus_tag="new_56193_56304" /HighExp="B60, B36, M9-stat, S2, BT, LoTm, Etha, Lbstat, T0.30H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S33" promotor_-35 55877..55881 /Source="Nicolas_upshift_promotors" /id="U49" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.895104895104895" /psig="0.996003996003996" /xcortree=2611 /SigmaFactorBS="agttgcactcaatagaaaattcttgcacttcatgaagtctCC TTGaaatcagaagatattTAGGATATATTTTTCTATGGataaaagggatattggaggc c" /listShort="gcaD, prs, ctc, pth, yabK, S34, mfd, S35, spoVT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 55897..55916 /Source="Nicolas_upshift_promotors" /id="U49" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.895104895104895" /psig="0.996003996003996" /xcortree=2611 /SigmaFactorBS="agttgcactcaatagaaaattcttgcacttcatgaagtctCC TTGaaatcagaagatattTAGGATATATTTTTCTATGGataaaagggatattggaggc c" /listShort="gcaD, prs, ctc, pth, yabK, S34, mfd, S35, spoVT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 55897 /Source="Nicolas_upshifts" /id="U49" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.895104895104895" /psig="0.996003996003996" /xcortree=2611 /SigmaFactorBS="agttgcactcaatagaaaattcttgcacttcatgaagtctCC TTGaaatcagaagatattTAGGATATATTTTTCTATGGataaaagggatattggaggc c" /listShort="gcaD, prs, ctc, pth, yabK, S34, mfd, S35, spoVT" /GFF_Attribute="listLong" /label="upshifts" CDS 55943..57313 /gene="glmU" /locus_tag="BSU_00500" /old_locus_tag="BSU00500" /EC_number="2.3.1.157" /EC_number="2.7.7.23" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1328164, 8522540, 9648743, 11124906, 20495944, 23485416, 24915076" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1328164, 8522540, 9648743, 11124906, 20495944, 23485416, 24915076; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional glucosamine-1-phosphate N-acetyltransferase/UDP-N-acetylglucosamine pyrophosphorylase" /protein_id="NP_387931.1" /db_xref="EnsemblGenomes-Gn:BSU00500" /db_xref="EnsemblGenomes-Tr:CAB11826" /db_xref="GOA:P14192" /db_xref="InterPro:IPR001451" /db_xref="InterPro:IPR005835" /db_xref="InterPro:IPR005882" /db_xref="InterPro:IPR011004" /db_xref="InterPro:IPR018357" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG10113" /db_xref="UniProtKB/Swiss-Prot:P14192" /translation="MDKRFAVVLAAGQGTRMKSKLYKVLHPVCGKPMVEHVVDEALKL SLSKLVTIVGHGAEEVKKQLGDKSEYALQAKQLGTAHAVKQAQPFLADEKGVTIVICG DTPLLTAETMEQMLKEHTQREAKATILTAVAEDPTGYGRIIRSENGAVQKIVEHKDAS EEERLVTEINTGTYCFDNEALFRAIDQVSNDNAQGEYYLPDVIEILKNEGETVAAYQT GNFQETLGVNDRVALSQAEQFMKERINKRHMQNGVTLIDPMNTYISPDAVIGSDTVIY PGTVIKGEVQIGEDTIIGPHTEIMNSAIGSRTVIKQSVVNHSKVGNDVNIGPFAHIRP DSVIGNEVKIGNFVEIKKTQFGDRSKASHLSYVGDAEVGTDVNLGCGSITVNYDGKNK YLTKIEDGAFIGCNSNLVAPVTVGEGAYVAAGSTVTEDVPGKALAIARARQVNKDDYV KNIHKK*" /label="glmU CDS" gene 55943..57313 /gene="glmU" /locus_tag="BSU_00500" /old_locus_tag="BSU00500" /label="glmU gene" downshifts complement(57288) /Source="Nicolas_upshifts" /id="D25" /incds=0 /nref=5 /ntot=84 /MaxReadThrough="2.39379" /MaxDrop="3.65636" /score="-7.65702938" /energy="-13.8" /TU="NA" /idTUdmin="U47" /TUdmin="-4312" /isTUend="FALSE" /label="downshifts" CDS 57336..58289 /gene="prs" /locus_tag="BSU_00510" /old_locus_tag="BSU00510" /EC_number="2.7.6.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2169413, 3038693, 8522540, 22083279, 25890046" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2169413, 3038693, 8522540, 22083279, 25890046; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylpyrophosphate synthetase" /protein_id="NP_387932.1" /db_xref="EnsemblGenomes-Gn:BSU00510" /db_xref="EnsemblGenomes-Tr:CAB11827" /db_xref="GOA:P14193" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR000842" /db_xref="InterPro:IPR005946" /db_xref="InterPro:IPR029057" /db_xref="InterPro:IPR029099" /db_xref="PDB:1DKR" /db_xref="PDB:1DKU" /db_xref="PDB:1IBS" /db_xref="SubtiList:BG10114" /db_xref="UniProtKB/Swiss-Prot:P14193" /translation="MSNQYGDKNLKIFSLNSNPELAKEIADIVGVQLGKCSVTRFSDG EVQINIEESIRGCDCYIIQSTSDPVNEHIMELLIMVDALKRASAKTINIVIPYYGYAR QDRKARSREPITAKLFANLLETAGATRVIALDLHAPQIQGFFDIPIDHLMGVPILGEY FEGKNLEDIVIVSPDHGGVTRARKLADRLKAPIAIIDKRRPRPNVAEVMNIVGNIEGK TAILIDDIIDTAGTITLAANALVENGAKEVYACCTHPVLSGPAVERINNSTIKELVVT NSIKLPEEKKIERFKQLSVGPLLAEAIIRVHEQQSVSYLFS*" /label="prs CDS" gene 57336..58289 /gene="prs" /locus_tag="BSU_00510" /old_locus_tag="BSU00510" /label="prs gene" promotor_-35 58302..58308 /Source="Nicolas_upshift_promotors" /id="U50" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=265 /SigmaFactorBS="agcaatcagtcagctatctgttcagctaaaccatttttcgaG GTTTAAatccttatcgttatGGGTATTGTTTGTAATAGGacaactaaaacgacaagag g" /listShort="ctc, pth, yabK, S34, mfd, S35, spoVT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 58321 /Source="Nicolas_upshifts" /id="U50" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=265 /SigmaFactorBS="agcaatcagtcagctatctgttcagctaaaccatttttcgaG GTTTAAatccttatcgttatGGGTATTGTTTGTAATAGGacaactaaaacgacaagag g" /listShort="ctc, pth, yabK, S34, mfd, S35, spoVT" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 58323..58341 /Source="Nicolas_upshift_promotors" /id="U50" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=265 /SigmaFactorBS="agcaatcagtcagctatctgttcagctaaaccatttttcgaG GTTTAAatccttatcgttatGGGTATTGTTTGTAATAGGacaactaaaacgacaagag g" /listShort="ctc, pth, yabK, S34, mfd, S35, spoVT" /GFF_Attribute="listLong" /label="promotor_-10" CDS 58374..58988 /gene="ctc" /locus_tag="BSU_00520" /old_locus_tag="BSU00520" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8522540, 9669336, 10369900, 12432960, 17198710" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8522540, 9669336, 10369900, 12432960, 17198710; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosomal protein BL25 (Ctc), binding 5S RNA" /protein_id="NP_387933.1" /db_xref="EnsemblGenomes-Gn:BSU00520" /db_xref="EnsemblGenomes-Tr:CAB11828" /db_xref="GOA:P14194" /db_xref="InterPro:IPR001021" /db_xref="InterPro:IPR011035" /db_xref="InterPro:IPR020056" /db_xref="InterPro:IPR020057" /db_xref="InterPro:IPR029751" /db_xref="InterPro:IPR037121" /db_xref="SubtiList:BG10115" /db_xref="UniProtKB/Swiss-Prot:P14194" /translation="MATLTAKERTDFTRSSLRNIRTSGHVPGIIYGKDTGNKPVSLDS VELIKTLRDEGKNAVITLEVSGEKHSVMVTDLQTDPLKNEITHADFQVVNMSEDIEVE VPIHLTGEAIGVKNGGVLQQPLYALTVKAKPKAIPQTIEADISSLDVNEVLTIADLPA GGDYSFNHESDEVVASILPPQQQEAAEVDEEESADAQPEGENEQ*" /label="ctc CDS" gene 58374..58988 /gene="ctc" /locus_tag="BSU_00520" /old_locus_tag="BSU00520" /label="ctc gene" downshifts 58972 /Source="Nicolas_upshifts" /id="D26" /incds=0 /nref=120 /ntot=249 /MaxReadThrough="8.65206" /MaxDrop="5.4784" /score="1.94770319" /energy="-11.2" /TU="U49,U50" /idTUdmin="U48" /TUdmin=682 /isTUend="FALSE" /label="downshifts" CDS 59095..59661 /gene="pth" /locus_tag="BSU_00530" /old_locus_tag="BSU00530" /EC_number="3.1.1.29" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:8635758, 12100553, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8635758, 12100553, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peptidyl-tRNA hydrolase" /protein_id="NP_387934.1" /db_xref="EnsemblGenomes-Gn:BSU00530" /db_xref="EnsemblGenomes-Tr:CAB11829" /db_xref="GOA:P37470" /db_xref="InterPro:IPR001328" /db_xref="InterPro:IPR018171" /db_xref="InterPro:IPR036416" /db_xref="SubtiList:BG10116" /db_xref="UniProtKB/Swiss-Prot:P37470" /translation="MLVIAGLGNPGKNYENTRHNVGFMVIDQLAKEWNIELNQNKFNG LYGTGFVSGKKVLLVKPLTYMNLSGECLRPLMDYYDVDNEDLTVIYDDLDLPTGKIRL RTKGSAGGHNGIKSLIQHLGTSEFDRIRIGIGRPVNGMKVVDYVLGSFTKEEAPEIEE AVDKSVKACEASLSKPFLEVMNEFNAKV*" /label="pth CDS" gene 59095..59661 /gene="pth" /locus_tag="BSU_00530" /old_locus_tag="BSU00530" /label="pth gene" misc_feature 59274..59277 /Source="Nicolas_upshift_promotors" /id="U51" /multdbtbs="-" /comp="M11" /sig="Sig-" /pcomp="0.210789210789211" /psig="0.210789210789211" /xcortree=737 /SigmaFactorBS="taacggattatacggaaccggatttgtttccggcaaaaaggt tctacttgttaaACCGcttacatatatgaatttatcaggagaatgtttgcggccttta a" /listShort="yabK, S34, mfd, S35, spoVT" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 59280 /Source="Nicolas_upshifts" /id="U51" /multdbtbs="-" /comp="M11" /sig="Sig-" /pcomp="0.210789210789211" /psig="0.210789210789211" /xcortree=737 /SigmaFactorBS="taacggattatacggaaccggatttgtttccggcaaaaaggt tctacttgttaaACCGcttacatatatgaatttatcaggagaatgtttgcggccttta a" /listShort="yabK, S34, mfd, S35, spoVT" /GFF_Attribute="listLong" /label="upshifts" CDS 59721..59951 /gene="fin" /locus_tag="BSU_00540" /old_locus_tag="BSU00540" /experiment="publication(s) with functional evidences, PMID:21037003, 28598017" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21037003, 28598017; Product type f: factor" /codon_start=1 /transl_table=11 /product="protein required for the switch from F to G during sporulation (anti sigma F)" /protein_id="NP_387935.1" /db_xref="EnsemblGenomes-Gn:BSU00540" /db_xref="EnsemblGenomes-Tr:CAB11830" /db_xref="GOA:P37553" /db_xref="InterPro:IPR020115" /db_xref="PDB:5MSL" /db_xref="SubtiList:BG10117" /db_xref="UniProtKB/Swiss-Prot:P37553" /translation="MALHYYCRHCGVKVGSLESSMVSTDSLGFQHLTNEERNDMISYK ENGDVHVLTICEDCQEALDRNPHYHEYHTFIQ*" /label="fin CDS" gene 59721..59951 /gene="fin" /locus_tag="BSU_00540" /old_locus_tag="BSU00540" /label="fin gene" S_feature 59952..60020 /Source="Nicolas_S_feature" /locus_tag="new_60361_60429" /HighExp="Etha, S5, S4, S7, S8, S6, S3, H2O2, Diami, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigB, SigA" /TUshortPSig="0.211, 1, 0.996" /TUlongSig="SigH" /TUlongPSig=1 /label="S34" CDS 60021..63554 /gene="mfd" /locus_tag="BSU_00550" /old_locus_tag="BSU00550" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8594198, 9535092, 11065368, 16950921, 22248542, 25713353, 27399782, 27435260" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8594198, 9535092, 11065368, 16950921, 22248542, 25713353, 27399782, 27435260; Product type f: factor" /codon_start=1 /transl_table=11 /product="transcription-repair coupling factor" /protein_id="NP_387936.1" /db_xref="EnsemblGenomes-Gn:BSU00550" /db_xref="EnsemblGenomes-Tr:CAB11831" /db_xref="GOA:P37474" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR003711" /db_xref="InterPro:IPR004576" /db_xref="InterPro:IPR005118" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036101" /db_xref="SubtiList:BG10118" /db_xref="UniProtKB/Swiss-Prot:P37474" /translation="MDNIQTFIKESDDFKSIINGLHEGLKEQLLAGLSGSARSVFTSA LANETNKPIFLITHNLYQAQKVTDDLTSLLEDRSVLLYPVNELISSEIAVASPELRAQ RLDVINRLTNGEAPIVVAPVAAIRRMLPPVEVWKSSQMLIQVGHDIEPDQLASRLVEV GYERSDMVSAPGEFSIRGGIIDIYPLTSENPVRIELFDTEVDSIRSFNSDDQRSIETL TSINIGPAKELIIRPEEKARAMEKIDSGLAASLKKLKADKQKEILHANISHDKERLSE GQTDQELVKYLSYFYEKPASLLDYTPDNTLLILDEVSRIHEMEEQLQKEEAEFITNLL EEGKILHDIRLSFSFQKIVAEQKRPLLYYSLFLRHVHHTSPQNIVNVSGRQMQSFHGQ MNVLAGEMERFKKSNFTVVFLGANKERTQKLSSVLADYDIEAAMTDSKKALVQGQVYI MEGELQSGFELPLMKLAVITEEELFKNRVKKKPRKQKLTNAERIKSYSELQIGDYVVH INHGIGKYLGIETLEINGIHKDYLNIHYQGSDKLYVPVEQIDQVQKYVGSEGKEPKLY KLGGSEWKRVKKKVETSVQDIADDLIKLYAEREASKGYAFSPDHEMQREFESAFPYQE TEDQLRSIHEIKKDMERERPMDRLLCGDVGYGKTEVAIRAAFKAIGDGKQVALLVPTT ILAQQHYETIKERFQDYPINIGLLSRFRTRKEANETIKGLKNGTVDIVIGTHRLLSKD VVYKDLGLLIIDEEQRFGVTHKEKIKQIKANVDVLTLTATPIPRTLHMSMLGVRDLSV IETPPENRFPVQTYVVEYNGALVREAIERELARGGQVYFLYNRVEDIERKADEISMLV PDAKVAYAHGKMTENELETVMLSFLEGESDVLVSTTIIETGVDIPNVNTLIVFDADKM GLSQLYQLRGRVGRSNRVAYAYFTYRRDKVLTEVAEKRLQAIKEFTELGSGFKIAMRD LTIRGAGNLLGAQQHGFIDSVGFDLYSQMLKEAIEERKGDTAKTEQFETEIDVELDAY IPETYIQDGKQKIDMYKRFRSVATIEEKNELQDEMIDRFGNYPKEVEYLFTVAEMKVY ARQERVELIKQDKDAVRLTISEEASAEIDGQKLFELGNQYGRQIGLGMEGKKLKISIQ TKGRSADEWLDTVLGMLKGLKDVKKQTISST*" /label="mfd CDS" gene 60021..63554 /gene="mfd" /locus_tag="BSU_00550" /old_locus_tag="BSU00550" /label="mfd gene" promotor_-35 63572..63578 /Source="Nicolas_upshift_promotors" /id="U52" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=914 /SigmaFactorBS="agcaaaccatttcatcaacgtaaattttgttactctctggTG TATATtacatttgatgtgACGGATACTAATttcaagcgaggcggaaggtacataaagt a" /listShort="S35, spoVT" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 63592..63689 /Source="Nicolas_S_feature" /locus_tag="new_64001_64098" /HighExp="S5, S7, S8, S6, S4, Etha, S3, H2O2, G135, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, Sig-, SigB, SigA" /TUshortPSig="1, 0.211, 1, 0.996" /TUlongSig="SigH" /TUlongPSig=1 /label="S35" promotor_-10 63592..63603 /Source="Nicolas_upshift_promotors" /id="U52" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=914 /SigmaFactorBS="agcaaaccatttcatcaacgtaaattttgttactctctggTG TATATtacatttgatgtgACGGATACTAATttcaagcgaggcggaaggtacataaagt a" /listShort="S35, spoVT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 63592 /Source="Nicolas_upshifts" /id="U52" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=914 /SigmaFactorBS="agcaaaccatttcatcaacgtaaattttgttactctctggTG TATATtacatttgatgtgACGGATACTAATttcaagcgaggcggaaggtacataaagt a" /listShort="S35, spoVT" /GFF_Attribute="listLong" /label="upshifts" CDS 63690..64226 /gene="spoVT" /locus_tag="BSU_00560" /old_locus_tag="BSU00560" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8755877, 15063493, 15939023, 16159768, 18996130, 22522895, 27790204" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8755877, 15063493, 15939023, 16159768, 18996130, 22522895, 27790204; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of sporulation / germination" /protein_id="NP_387937.1" /db_xref="EnsemblGenomes-Gn:BSU00560" /db_xref="EnsemblGenomes-Tr:CAB11832" /db_xref="GOA:P37554" /db_xref="InterPro:IPR007159" /db_xref="InterPro:IPR014213" /db_xref="PDB:2RO5" /db_xref="PDB:2W1R" /db_xref="PDB:2W1T" /db_xref="SubtiList:BG10119" /db_xref="UniProtKB/Swiss-Prot:P37554" /translation="MKATGIVRRIDDLGRVVIPKEIRRTLRIREGDPLEIFVDRDGEV ILKKYSPISELGDFAKEYADALYDSLGHSVLICDRDVYIAVSGSSKKDYLNKSISEML ERTMDQRSSVLESDAKSVQLVNGIDEDMNSYTVGPIVANGDPIGAVVIFSKDQTMGEV EHKAVETAAGFLARQMEQ*" /label="spoVT CDS" gene 63690..64226 /gene="spoVT" /locus_tag="BSU_00560" /old_locus_tag="BSU00560" /label="spoVT gene" downshifts 64230 /Source="Nicolas_upshifts" /id="D27" /incds=0 /nref=236 /ntot=260 /MaxReadThrough="1.92082" /MaxDrop="6.20706" /score="-2.69593259" /energy="-11.6" /TU="NA" /idTUdmin="U49" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature 64326..64345 /Source="Nicolas_upshift_promotors" /id="U53" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.946053946053946" /psig=1 /xcortree=1839 /SigmaFactorBS="gacgctgttctttttcatgcgtgccgaaaaaggaatccaagg gttgggaTGTGGTATAATAACCTCGTTtttatttgtgccgcggtaatacgtgaaccgt a" /listShort="yabM, yabN, yabO, yabP, yabQ, divIC, yabR" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 64337 /Source="Nicolas_upshifts" /id="U53" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.946053946053946" /psig=1 /xcortree=1839 /SigmaFactorBS="gacgctgttctttttcatgcgtgccgaaaaaggaatccaagg gttgggaTGTGGTATAATAACCTCGTTtttatttgtgccgcggtaatacgtgaaccgt a" /listShort="yabM, yabN, yabO, yabP, yabQ, divIC, yabR" /GFF_Attribute="listLong" /label="upshifts" CDS 64408..66006 /gene="yabM" /locus_tag="BSU_00570" /old_locus_tag="BSU00570" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative exporter" /protein_id="NP_387938.1" /db_xref="EnsemblGenomes-Gn:BSU00570" /db_xref="EnsemblGenomes-Tr:CAB11833" /db_xref="GOA:P37555" /db_xref="InterPro:IPR002797" /db_xref="InterPro:IPR024923" /db_xref="InterPro:IPR029303" /db_xref="SubtiList:BG10120" /db_xref="UniProtKB/Swiss-Prot:P37555" /translation="MDDSIGVKRHWIWQGAFVLILAGVITKILSAVYRVPFQNIVGDV GFYIYQQVYPFLGIAVMLSTSGFPVIISKLMNDYSEKNHHTILKISALFLSLIGILLF LCLYLGAVPIALFMGDSHLAVLIQVAAYAFLLFPFVALLRGGFQGRHEMLPSALSQMT EQFLRVAVLLGLSFWLVKKGASLYTAGAAAASGSLAGSLVALIILGFFWFKTKRDNQT DRQNENVITTKELTKKLLLYSVTICVSSLLLLFIQLVDALNLYALLSGGEASEEAKCL KGIYDRGQPLLQLGSVFAVSIATSLVPYISMAVKNKELKIMKEKITSSLKLCLVLGTG ASAGLICILKPVNIMLFQNGEGTGALQVFSCSILFASLAVTAAAVLQGAGYTVFPAIA VGAGVAVKWVLNTLLVPRYGIEGASLATAASFAAVAGLNLYQLRQKEWLDKLRGVLIP IIGSALLMSAVLLAYTRLWTFLFPATGRGAAVIESLSAVAIGGAVFIYCMMRLGIFTD EELNSVPFGSKLSKFMRRREQNGG*" /label="yabM CDS" gene 64408..66006 /gene="yabM" /locus_tag="BSU_00570" /old_locus_tag="BSU00570" /label="yabM gene" promotor_-35 65877..65884 /Source="Nicolas_upshift_promotors" /id="U54" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.739260739260739" /psig="0.798201798201798" /xcortree=108 /SigmaFactorBS="gattgagagtctttctgctgttgcCATTGGTGgcgcggtgtt tattTATTGTATGATGAGATTGGGaatatttacagatgaagagctgaacagtgtgcca t" /listShort="yabN, yabO, yabP, yabQ" /listLong="divIC, yabR" /label="promotor_-35" promotor_-10 65899..65918 /Source="Nicolas_upshift_promotors" /id="U54" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.739260739260739" /psig="0.798201798201798" /xcortree=108 /SigmaFactorBS="gattgagagtctttctgctgttgcCATTGGTGgcgcggtgtt tattTATTGTATGATGAGATTGGGaatatttacagatgaagagctgaacagtgtgcca t" /listShort="yabN, yabO, yabP, yabQ" /listLong="divIC, yabR" /label="promotor_-10" upshifts 65913 /Source="Nicolas_upshifts" /id="U54" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.739260739260739" /psig="0.798201798201798" /xcortree=108 /SigmaFactorBS="gattgagagtctttctgctgttgcCATTGGTGgcgcggtgtt tattTATTGTATGATGAGATTGGGaatatttacagatgaagagctgaacagtgtgcca t" /listShort="yabN, yabO, yabP, yabQ" /listLong="divIC, yabR" /label="upshifts" CDS 65996..67465 /gene="yabN" /locus_tag="BSU_00580" /old_locus_tag="BSU00580" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11178267; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative fusion methylase and nucleotide pyrophosphohydrolase" /protein_id="NP_387939.1" /db_xref="EnsemblGenomes-Gn:BSU00580" /db_xref="EnsemblGenomes-Tr:CAB11834" /db_xref="GOA:P37556" /db_xref="InterPro:IPR000878" /db_xref="InterPro:IPR004518" /db_xref="InterPro:IPR011551" /db_xref="InterPro:IPR014777" /db_xref="InterPro:IPR024180" /db_xref="InterPro:IPR035013" /db_xref="InterPro:IPR035996" /db_xref="SubtiList:BG10121" /db_xref="UniProtKB/Swiss-Prot:P37556" /translation="MAGKITVVGLGAGDMDQLTIGIHKLLTKADTLYVRTKDHPLIEE LEKETKNIRFFDDIYEKHDQFEAVYEEIADILFEAARREDVVYAVPGHPFVAEKTVQL LTERQEKENVQVKVAGGQSFLDATFNVLQIDPIEGFQFVDAGTLSADELELRHHLIIC QVYDQMTASEVKLTLMEKLPDDYEVVIVTAAGSRGEEIRTVPLFELDRNVALNNLTSV YIPPIKEEKLLYHEFSTFRSIIRELRGPNGCPWDKKQTHQSLKQYMIEECYELLEAID EEDTDHMIEELGDVLLQVLLHAQIGEDEGYFTIDDVIKGISEKMVRRHPHVFKDVKVQ DENDVLANWEDIKKAEKNTSESSLLDSVPKTLPALSKAAKLQKKAAKVGFDWEDVSDI WEKVSEEMKEFSSEVSEAPHEHNLKAEFGDILFALVNVARFYKIEPEEALTMTNDKFR RRFSYIEETAKEEGVELADMSLEDMDKLWNEAKETERRS*" /label="yabN CDS" gene 65996..67465 /gene="yabN" /locus_tag="BSU_00580" /old_locus_tag="BSU00580" /label="yabN gene" promotor_-35 66637..66644 /Source="Nicolas_upshift_promotors" /id="U55" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2822 /SigmaFactorBS="tggaccgcaatgtcgctttgaacaaCTTAACAAgtgtgtata ttccGCCGATTAAAGAAGAGAAGctgctttatcacgaattctccacgttccgaagcat c" /listShort="yabO, yabP, yabQ, divIC, yabR" /listLong="trnSL-Met1" /label="promotor_-35" promotor_-10 66658..66676 /Source="Nicolas_upshift_promotors" /id="U55" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2822 /SigmaFactorBS="tggaccgcaatgtcgctttgaacaaCTTAACAAgtgtgtata ttccGCCGATTAAAGAAGAGAAGctgctttatcacgaattctccacgttccgaagcat c" /listShort="yabO, yabP, yabQ, divIC, yabR" /listLong="trnSL-Met1" /label="promotor_-10" upshifts 66672 /Source="Nicolas_upshifts" /id="U55" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2822 /SigmaFactorBS="tggaccgcaatgtcgctttgaacaaCTTAACAAgtgtgtata ttccGCCGATTAAAGAAGAGAAGctgctttatcacgaattctccacgttccgaagcat c" /listShort="yabO, yabP, yabQ, divIC, yabR" /listLong="trnSL-Met1" /label="upshifts" promotor_no_box complement(67060..67160) /Source="Nicolas_upshift_promotors" /id="U56" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.984015984015984" /psig="0.001998001998002" /xcortree=37 /SigmaFactorBS="cgtcttcccagtcaaaaccgaccttcgctgcttttttctgca atttagctgctttcgaaagagctggaagggttttcggtacgctgtctagtaatgatga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(67100) /Source="Nicolas_upshifts" /id="U56" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.984015984015984" /psig="0.001998001998002" /xcortree=37 /SigmaFactorBS="cgtcttcccagtcaaaaccgaccttcgctgcttttttctgca atttagctgctttcgaaagagctggaagggttttcggtacgctgtctagtaatgatga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 67468..67728 /gene="hslR" /locus_tag="BSU_00590" /old_locus_tag="BSU00590" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10675343, 10675344, 19013177; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosomal RNA binding protein involved in 50S recycling; heat shock protein" /protein_id="NP_387940.1" /db_xref="EnsemblGenomes-Gn:BSU00590" /db_xref="EnsemblGenomes-Tr:CAB11835" /db_xref="GOA:P37557" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR025490" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG10122" /db_xref="UniProtKB/Swiss-Prot:P37557" /translation="MRLDKFLKVSRLIKRRTLAKEVADQGRISINGNQAKASSDVKPG DELTVRFGQKLVTVQVNELKDTTKKEEAANMYTILKEEKLGE*" /label="hslR CDS" gene 67468..67728 /gene="hslR" /locus_tag="BSU_00590" /old_locus_tag="BSU00590" /label="hslR gene" promotor_-35 67733..67738 /Source="Nicolas_upshift_promotors" /id="U57" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1397 /SigmaFactorBS="aaaaactcggcgaataggcttGTTCTAaaaaaaccccccacc TCATACAATGCAGTAATAAtgctaaaagtatcgaggatatgggggctgaatagatgaa t" /listShort="yabP, yabQ, divIC, yabR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 67754..67772 /Source="Nicolas_upshift_promotors" /id="U57" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1397 /SigmaFactorBS="aaaaactcggcgaataggcttGTTCTAaaaaaaccccccacc TCATACAATGCAGTAATAAtgctaaaagtatcgaggatatgggggctgaatagatgaa t" /listShort="yabP, yabQ, divIC, yabR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 67772 /Source="Nicolas_upshifts" /id="U57" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1397 /SigmaFactorBS="aaaaactcggcgaataggcttGTTCTAaaaaaaccccccacc TCATACAATGCAGTAATAAtgctaaaagtatcgaggatatgggggctgaatagatgaa t" /listShort="yabP, yabQ, divIC, yabR" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(67804) /Source="Nicolas_upshifts" /id="D28" /incds=0 /nref=3 /ntot=19 /MaxReadThrough="1.93659" /MaxDrop="3.17193" /score="-0.425236437" /energy="-13.9" /TU="NA" /idTUdmin="U62" /TUdmin=3014 /isTUend="FALSE" /label="downshifts" CDS 67807..68109 /gene="spcP" /locus_tag="BSU_00600" /old_locus_tag="BSU00600" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10869437, 11283287, 15231775, 21904870, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10869437, 11283287, 15231775, 21904870, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="spore protein involved in the shaping of the spore coat" /protein_id="NP_387941.1" /db_xref="EnsemblGenomes-Gn:BSU00600" /db_xref="EnsemblGenomes-Tr:CAB11836" /db_xref="GOA:P37558" /db_xref="InterPro:IPR012504" /db_xref="InterPro:IPR022476" /db_xref="SubtiList:BG10123" /db_xref="UniProtKB/Swiss-Prot:P37558" /translation="MNSYYDQKGSSSVPEQHDVTMKGRKHLDISGVKHVESFDNEEFL LETVMGMLSVRGQNLQMKNLDVEKGIVSIKGRVFDLVYLDEQQGDKAKGFFSKLFK*" /label="spcP CDS" gene 67807..68109 /gene="spcP" /locus_tag="BSU_00600" /old_locus_tag="BSU00600" /label="spcP gene" CDS 68106..68741 /gene="spcQ" /locus_tag="BSU_00610" /old_locus_tag="BSU00610" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10869437, 11283287, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10869437, 11283287, 15849754, 16850406; Product type f: factor" /codon_start=1 /transl_table=11 /product="membrane protein of the forespore" /protein_id="NP_387942.1" /db_xref="EnsemblGenomes-Gn:BSU00610" /db_xref="EnsemblGenomes-Tr:CAB11837" /db_xref="GOA:P37559" /db_xref="InterPro:IPR014242" /db_xref="InterPro:IPR019074" /db_xref="SubtiList:BG10124" /db_xref="UniProtKB/Swiss-Prot:P37559" /translation="MTLTTQFYTMLAMSGMGLWLGASLDTYRLFVIRAKTARWLLFIH DILFWIMQGLLFFYVLLHVNEGEFRIYIFLAVLLGVATYQSLCKRIYIKILKFVIYLV VSVYQFFKKLIQHVLFRPIVWTCGAIIWLAAFLFKKTYSLIGFLLLCLYKIVMVLCFP IRFIAKQCLKLLPVKMRLTFRRYFEKGAGFLKKKKKLLITIRTTITRFLKR*" /label="spcQ CDS" gene 68106..68741 /gene="spcQ" /locus_tag="BSU_00610" /old_locus_tag="BSU00610" /label="spcQ gene" promotor_-35 68611..68620 /Source="Nicolas_upshift_promotors" /id="U58" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1706 /SigmaFactorBS="tgtgttttccgatccgttttatcgcgaaacaatgttTGAAAC TTCTtcctgtgaaaatGCGTCTAACTTTTAGAcgttattttgaaaaaggtgcaggatt t" /listShort="divIC, yabR, trnSL-Met1, trnSL-Glu1, S36" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 68633..68648 /Source="Nicolas_upshift_promotors" /id="U58" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1706 /SigmaFactorBS="tgtgttttccgatccgttttatcgcgaaacaatgttTGAAAC TTCTtcctgtgaaaatGCGTCTAACTTTTAGAcgttattttgaaaaaggtgcaggatt t" /listShort="divIC, yabR, trnSL-Met1, trnSL-Glu1, S36" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 68635 /Source="Nicolas_upshifts" /id="U58" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1706 /SigmaFactorBS="tgtgttttccgatccgttttatcgcgaaacaatgttTGAAAC TTCTtcctgtgaaaatGCGTCTAACTTTTAGAcgttattttgaaaaaggtgcaggatt t" /listShort="divIC, yabR, trnSL-Met1, trnSL-Glu1, S36" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 68667..68675 /Source="Nicolas_upshift_promotors" /id="U59" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=532 /SigmaFactorBS="tctaacttttagacgttattttgaaaaaggtGCAGGATTTct caaaaagaAGAAGAAACTATTGATAACcataagaacgaccatcacacggtttttgaag a" /listShort="divIC, yabR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 68686..68704 /Source="Nicolas_upshift_promotors" /id="U59" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=532 /SigmaFactorBS="tctaacttttagacgttattttgaaaaaggtGCAGGATTTct caaaaagaAGAAGAAACTATTGATAACcataagaacgaccatcacacggtttttgaag a" /listShort="divIC, yabR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 68696 /Source="Nicolas_upshifts" /id="U59" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=532 /SigmaFactorBS="tctaacttttagacgttattttgaaaaaggtGCAGGATTTct caaaaagaAGAAGAAACTATTGATAACcataagaacgaccatcacacggtttttgaag a" /listShort="divIC, yabR" /GFF_Attribute="listLong" /label="upshifts" CDS 68759..69136 /gene="divIC" /locus_tag="BSU_00620" /old_locus_tag="BSU00620" /function="16.13: Shape" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:10844672, 11283287, 11994149, 12682299, 16936019, 20870765, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10844672, 11283287, 11994149, 12682299, 16936019, 20870765, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="cell-division initiation protein" /protein_id="NP_387943.1" /db_xref="EnsemblGenomes-Gn:BSU00620" /db_xref="EnsemblGenomes-Tr:CAB11838" /db_xref="GOA:P37471" /db_xref="InterPro:IPR007060" /db_xref="SubtiList:BG10125" /db_xref="UniProtKB/Swiss-Prot:P37471" /translation="MNFSRERTITEIQNDYKEQVERQNQLKKRRRKGLYRRLTVFGAL VFLTAIVLASSVWSQTSSLSAKEEKKEQLEKELKSLKTKQTDLKEEISKLKDEDYVTE LARRDLFMSGDGEIIFNVEKKSK*" /label="divIC CDS" gene 68759..69136 /gene="divIC" /locus_tag="BSU_00620" /old_locus_tag="BSU00620" /label="divIC gene" CDS 69217..69603 /gene="yabR" /locus_tag="BSU_00630" /old_locus_tag="BSU00630" /EC_number="2.7.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9862121, 15066026, 16014871, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA degradation protein; polyribonucleotide nucleotidyltransferase or phosphorylase" /protein_id="NP_387944.1" /db_xref="EnsemblGenomes-Gn:BSU00630" /db_xref="EnsemblGenomes-Tr:CAB11839" /db_xref="GOA:P37560" /db_xref="InterPro:IPR003029" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR022967" /db_xref="SubtiList:BG10126" /db_xref="UniProtKB/Swiss-Prot:P37560" /translation="MSIEVGSKLQGKITGITNFGAFVELPGGSTGLVHISEVADNYVK DINDHLKVGDQVEVKVINVEKDGKIGLSIKKAKDRPQARPRNDFRPKESFEQKMNKFL KDSEDRLSSLKRNTESKRGGRGARRG*" /label="yabR CDS" gene 69217..69603 /gene="yabR" /locus_tag="BSU_00630" /old_locus_tag="BSU00630" /label="yabR gene" downshifts 69597 /Source="Nicolas_upshifts" /id="D29" /incds=0 /nref=247 /ntot=274 /MaxReadThrough="3.67278" /MaxDrop="8.3221" /score="23.2738869" /energy="-12.5" /TU="U58" /idTUdmin="U53" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 69711..69718 /Source="Nicolas_upshift_promotors" /id="U60" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.85914085914086" /psig=1 /xcortree=2412 /SigmaFactorBS="gaaaattacaacattaaagtttctGTTGACGAaagagacaaa cctTTGTATTATATAACTTGTGCttagaagcacaaaacaatatggcggtgtagctcag c" /listShort="trnSL-Met1, trnSL-Glu1, S36, spoIIE, yabS, yabT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 69732..69751 /Source="Nicolas_upshift_promotors" /id="U60" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.85914085914086" /psig=1 /xcortree=2412 /SigmaFactorBS="gaaaattacaacattaaagtttctGTTGACGAaagagacaaa cctTTGTATTATATAACTTGTGCttagaagcacaaaacaatatggcggtgtagctcag c" /listShort="trnSL-Met1, trnSL-Glu1, S36, spoIIE, yabS, yabT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 69747 /Source="Nicolas_upshifts" /id="U60" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.85914085914086" /psig=1 /xcortree=2412 /SigmaFactorBS="gaaaattacaacattaaagtttctGTTGACGAaagagacaaa cctTTGTATTATATAACTTGTGCttagaagcacaaaacaatatggcggtgtagctcag c" /listShort="trnSL-Met1, trnSL-Glu1, S36, spoIIE, yabS, yabT" /GFF_Attribute="listLong" /label="upshifts" tRNA 69772..69848 /gene="trnSL-Met1" /locus_tag="BSU_tRNA_10" /product="tRNA-Met" /inference="profile:tRNAscan:1.23" /note="methionine transfer RNA (CAU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Met1 tRNA" gene 69772..69848 /gene="trnSL-Met1" /locus_tag="BSU_tRNA_10" /label="trnSL-Met1 gene" tRNA 69858..69929 /gene="trnSL-Glu1" /locus_tag="BSU_tRNA_11" /product="tRNA-Glu" /inference="profile:tRNAscan:1.23" /note="glutamate transfer RNA (UUC); Evidence 2a: Functionfrom experimental evidences in other organisms; Producttype n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Glu1 tRNA" gene 69858..69929 /gene="trnSL-Glu1" /locus_tag="BSU_tRNA_11" /label="trnSL-Glu1 gene" downshifts 69928 /Source="Nicolas_upshifts" /id="D30" /incds=0 /nref=2 /ntot=58 /MaxReadThrough="4.83761" /MaxDrop="5.55326" /score="25.2769629" /energy="-10.8" /TU="U58,U60" /idTUdmin="U58" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" S_feature 69973..70084 /Source="Nicolas_S_feature" /locus_tag="new_70382_70493" /HighExp="Cold, G180, C30, G135, G150, Oxctl, Paraq, H2O2, Heat, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigWXY" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S36" misc_feature 70080..70099 /Source="Nicolas_upshift_promotors" /id="U61" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.632367632367632" /psig="0.99000999000999" /xcortree=442 /SigmaFactorBS="cgtcgaagatttctttggtattgttaccttcttttgacaaaa tcctatctgtgcTTTCGCTATAATGACAGGCAacgaatataacaggtgggagatgaga g" /listShort="spoIIE, yabS, yabT, tilS" /listLong="hprT, S38, ftsH" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 70086 /Source="Nicolas_upshifts" /id="U61" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.632367632367632" /psig="0.99000999000999" /xcortree=442 /SigmaFactorBS="cgtcgaagatttctttggtattgttaccttcttttgacaaaa tcctatctgtgcTTTCGCTATAATGACAGGCAacgaatataacaggtgggagatgaga g" /listShort="spoIIE, yabS, yabT, tilS" /listLong="hprT, S38, ftsH" /label="upshifts" CDS 70129..72612 /gene="spoIIE" /locus_tag="BSU_00640" /old_locus_tag="BSU00640" /EC_number="3.1.3.16" /function="16.3: Control" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10747015, 12180929, 15126482, 15866939, 15978076, 28358838" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10747015, 12180929, 15126482, 15866939, 15978076, 28358838; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="SpoIIAA-phosphate serine phosphatase" /protein_id="NP_387945.1" /db_xref="EnsemblGenomes-Gn:BSU00640" /db_xref="EnsemblGenomes-Tr:CAB11840" /db_xref="GOA:P37475" /db_xref="InterPro:IPR001932" /db_xref="InterPro:IPR014221" /db_xref="InterPro:IPR036457" /db_xref="PDB:3T91" /db_xref="PDB:3T9Q" /db_xref="PDB:5UCG" /db_xref="SubtiList:BG10127" /db_xref="UniProtKB/Swiss-Prot:P37475" /translation="MEKAERRVNGPMAGQALEKLQSFFNRGTKLVTHHLHSLFFYKGF IYVVIGFLLGRAFILSEVLPFALPFFGAMLLIRRDKAFYAVLAVLAGALTISPKHSLL ILAALLAFFVFSKVAAFITDDRVKALPIVVFFSMAAARAGFVYAQNGVFTTYDYVMAI VEAGLSFILTLIFLQSLPIFTVKKVKQSLKIEEIICFMILIASVLTGLAGLSYQGMQA EHILARYVVLSFSFIGGASIGCTVGVVTGLILGLANIGNLYQMSLLAFSGLLGGLLKE GKKAGAAIGLIVGSLLISLYGEGSAGLMTTLYESLIAVCLFLLTPQSITRKVARYIPG TVEHLQEQQQYARKIRDVTAQKVDQFSNVFHALSESFATFYQASDEQTDDSEVDLFLS KITEHSCQTCYKKNRCWVQNFDKTYDLMKQVMLETEEKEYASNRRLKKEFQQYCSKSK QVEELIEDELAHHHAHLTLKKKVQDSRRLVAEQLLGVSEVMADFSREIKREREQHFLQ EEQIIEALQHFGIEIQHVEIYSLEQGNIDIEMTIPFSGHGESEKIIAPMLSDILEEQI LVKAEQHSPHPNGYSHVAFGSTKSYRVSTGAAHAAKGGGLVSGDSYSMMELGARKYAA AISDGMGNGARAHFESNETIKLLEKILESGIDEKIAIKTINSILSLRTTDEIYSTLDL SIIDLQDASCKFLKVGSTPSFIKRGDQVMKVQASNLPIGIINEFDVEVVSEQLKAGDL LIMMSDGIFEGPKHVENHDLWMKRKMKGLKTNDPQEIADLLMEEVIRTRSGQIEDDMT VVVVRIDHNTPKWASIPVPAIFQNKQEIS*" /label="spoIIE CDS" gene 70129..72612 /gene="spoIIE" /locus_tag="BSU_00640" /old_locus_tag="BSU00640" /label="spoIIE gene" downshifts 70170 /Source="Nicolas_upshifts" /id="D31" /incds=0 /nref=1 /ntot=20 /MaxReadThrough="5.5737" /MaxDrop="3.93473" /score="25.2769629" /energy="-10.8" /TU="U60,U61" /idTUdmin="U58" /TUdmin=44 /isTUend="FALSE" /label="downshifts" S_feature complement(70781..71390) /Source="Nicolas_S_feature" /locus_tag="new_71190_71799_c" /HighExp="S8, S6, S4, S5, S3, S7, M9-stat, T5.0H, LoTm, Pyr" /AntisenseName="spoIIE" /AntisenseCor="0.685558251745638" /AntisenseRegPval="-38" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S37" downshifts complement(70807) /Source="Nicolas_upshifts" /id="D32" /incds=1 /nref=2 /ntot=11 /MaxReadThrough="2.2425" /MaxDrop="4.29972" /score="-0.425236437" /energy="-13.9" /TU="NA" /idTUdmin="U62" /TUdmin=11 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(71363..71381) /Source="Nicolas_upshift_promotors" /id="U62" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1071 /SigmaFactorBS="cttttttcagccttcggtttgatgcatattctttttcctctg tttcaAGCATAacttgtttcattaagTCATATGTTTTATCAAAGTtctgtacccagca c" /listShort="S37" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(71389) /Source="Nicolas_upshifts" /id="U62" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1071 /SigmaFactorBS="cttttttcagccttcggtttgatgcatattctttttcctctg tttcaAGCATAacttgtttcattaagTCATATGTTTTATCAAAGTtctgtacccagca c" /listShort="S37" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(71397..71402) /Source="Nicolas_upshift_promotors" /id="U62" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1071 /SigmaFactorBS="cttttttcagccttcggtttgatgcatattctttttcctctg tttcaAGCATAacttgtttcattaagTCATATGTTTTATCAAAGTtctgtacccagca c" /listShort="S37" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 71594..71600 /Source="Nicolas_upshift_promotors" /id="U63" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=158 /SigmaFactorBS="ccttgttgctgaacagcttttaggcgtttctgAGGTTATggc cgacttttctcGGGAAATAAAAAGAGAGCGagaacaacactttctgcaggaagagcaa a" /listShort="yabS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 71615..71633 /Source="Nicolas_upshift_promotors" /id="U63" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=158 /SigmaFactorBS="ccttgttgctgaacagcttttaggcgtttctgAGGTTATggc cgacttttctcGGGAAATAAAAAGAGAGCGagaacaacactttctgcaggaagagcaa a" /listShort="yabS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 71622 /Source="Nicolas_upshifts" /id="U63" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=158 /SigmaFactorBS="ccttgttgctgaacagcttttaggcgtttctgAGGTTATggc cgacttttctcGGGAAATAAAAAGAGAGCGagaacaacactttctgcaggaagagcaa a" /listShort="yabS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 72632..72635 /Source="Nicolas_upshift_promotors" /id="U64" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.842157842157842" /psig="0.842157842157842" /xcortree=1198 /SigmaFactorBS="aacaagaaatttcataacgcttccgtataaatcaaaTTTCtt ctggcgaagatgggaATATATGAATCTGAGAATcctcgtattctccaggaggaatgaa t" /listShort="yabS, yabT, tilS, hprT, S38, ftsH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 72653..72670 /Source="Nicolas_upshift_promotors" /id="U64" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.842157842157842" /psig="0.842157842157842" /xcortree=1198 /SigmaFactorBS="aacaagaaatttcataacgcttccgtataaatcaaaTTTCtt ctggcgaagatgggaATATATGAATCTGAGAATcctcgtattctccaggaggaatgaa t" /listShort="yabS, yabT, tilS, hprT, S38, ftsH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 72656 /Source="Nicolas_upshifts" /id="U64" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.842157842157842" /psig="0.842157842157842" /xcortree=1198 /SigmaFactorBS="aacaagaaatttcataacgcttccgtataaatcaaaTTTCtt ctggcgaagatgggaATATATGAATCTGAGAATcctcgtattctccaggaggaatgaa t" /listShort="yabS, yabT, tilS, hprT, S38, ftsH" /GFF_Attribute="listLong" /label="upshifts" CDS 72697..73434 /gene="yabS" /locus_tag="BSU_00650" /old_locus_tag="BSU00650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_387946.1" /db_xref="EnsemblGenomes-Gn:BSU00650" /db_xref="EnsemblGenomes-Tr:CAB11841" /db_xref="InterPro:IPR002035" /db_xref="InterPro:IPR036465" /db_xref="SubtiList:BG10128" /db_xref="UniProtKB/Swiss-Prot:P37561" /translation="MNNGHLNQILLITDGCSNHGEDPLAMAAFAKEQGITVNVIGIME ENQIDPEAMKEVEGIALAGGGVHQVVYASQLSQTVQMVTKKAMTQTLQGVVNQELKQI LGKNVEMEELSPEKRGEVMEVVDELGETVHLQVLVLVDTSASMAPKLPTVKEALIDLS VSLNSRIGNNEFAMCIFPGKKQEVELVLNWTPKLQSLSTLFAKLSTGGITPTGPAIRE ATLQFEKIRSRRGMLADDERRFDEFGM*" /label="yabS CDS" gene 72697..73434 /gene="yabS" /locus_tag="BSU_00650" /old_locus_tag="BSU00650" /label="yabS gene" CDS 73400..74416 /gene="prkT" /locus_tag="BSU_00660" /old_locus_tag="BSU00660" /EC_number="2.7.11.1" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:23634894, 24731262, 25278935" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23634894, 24731262, 25278935; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="serine/threonine-protein kinase" /protein_id="NP_387947.2" /db_xref="EnsemblGenomes-Gn:BSU00660" /db_xref="EnsemblGenomes-Tr:CAB11842" /db_xref="GOA:P37562" /db_xref="InterPro:IPR000719" /db_xref="InterPro:IPR011009" /db_xref="InterPro:IPR017441" /db_xref="SubtiList:BG10129" /db_xref="UniProtKB/Swiss-Prot:P37562" /translation="MMNDALTSLACSLKPGTTIKGKWNGNTYTLRKQLGKGANGIVYL AETSDGHVALKVSDDSLSITSEVNVLKSFSKAQSVTMGPSFFDTDDAYIPSANTKVSF YAMEYIKGPLLLKYVSDKGAEWIPVLMIQLLSSLSVLHQQGWIFGDLKPDNLIVTGPP ARIRCIDVGGTTKEGRAIKEYTEFYDRGYWGYGTRKAEPSYDLFAVAMIMINSVHKKE FKKTNQPKEQLRSLIEGNPLLQKYKKALFSALNGDYQSADEMKKDMLDAGQKAAQRKQ PIKASPQPATRQRQQKPRQGKITKTRYTPKQKPAKSGGLFETTLIVISVLALYFAYII FFLI*" /label="prkT CDS" gene 73400..74416 /gene="prkT" /locus_tag="BSU_00660" /old_locus_tag="BSU00660" /label="prkT gene" promotor_-35 73948..73954 /Source="Nicolas_upshift_promotors" /id="U65" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=159 /SigmaFactorBS="aaggaaggccgggcgataaaagagtatacggaGTTTTATgac agaggctattggGGGTATGGAACAAGAAAGGcagagccatcctatgatctgttcgcag t" /GFF_Attribute="listShort" /listLong="tilS, hprT, S38, ftsH" /label="promotor_-35" promotor_-10 73970..73988 /Source="Nicolas_upshift_promotors" /id="U65" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=159 /SigmaFactorBS="aaggaaggccgggcgataaaagagtatacggaGTTTTATgac agaggctattggGGGTATGGAACAAGAAAGGcagagccatcctatgatctgttcgcag t" /GFF_Attribute="listShort" /listLong="tilS, hprT, S38, ftsH" /label="promotor_-10" upshifts 73976 /Source="Nicolas_upshifts" /id="U65" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=159 /SigmaFactorBS="aaggaaggccgggcgataaaagagtatacggaGTTTTATgac agaggctattggGGGTATGGAACAAGAAAGGcagagccatcctatgatctgttcgcag t" /GFF_Attribute="listShort" /listLong="tilS, hprT, S38, ftsH" /label="upshifts" promotor_-35 74446..74453 /Source="Nicolas_upshift_promotors" /id="U66" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.723276723276723" /psig=1 /xcortree=1948 /SigmaFactorBS="atggtgcaaactgcagagcctatgcttctTCTTTGCTtggag gggttgaaAGTGTTAGGATATGAATATCtttaaaatacctgctcattgtgaggaggac a" /listShort="tilS, hprT, S38, ftsH, S39, S40, coaX, hslO, yacD" /listLong="cysK, pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="promotor_-35" promotor_-10 74467..74486 /Source="Nicolas_upshift_promotors" /id="U66" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.723276723276723" /psig=1 /xcortree=1948 /SigmaFactorBS="atggtgcaaactgcagagcctatgcttctTCTTTGCTtggag gggttgaaAGTGTTAGGATATGAATATCtttaaaatacctgctcattgtgaggaggac a" /listShort="tilS, hprT, S38, ftsH, S39, S40, coaX, hslO, yacD" /listLong="cysK, pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="promotor_-10" upshifts 74477 /Source="Nicolas_upshifts" /id="U66" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.723276723276723" /psig=1 /xcortree=1948 /SigmaFactorBS="atggtgcaaactgcagagcctatgcttctTCTTTGCTtggag gggttgaaAGTGTTAGGATATGAATATCtttaaaatacctgctcattgtgaggaggac a" /listShort="tilS, hprT, S38, ftsH, S39, S40, coaX, hslO, yacD" /listLong="cysK, pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="upshifts" CDS 74520..75938 /gene="tilS" /locus_tag="BSU_00670" /old_locus_tag="BSU00670" /EC_number="6.3.4.19" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14527414, 16039592, 17005971, 22720735, 24001521" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14527414, 16039592, 17005971, 22720735, 24001521; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="tRNA(ile2) lysidine synthetase" /protein_id="NP_387948.1" /db_xref="EnsemblGenomes-Gn:BSU00670" /db_xref="EnsemblGenomes-Tr:CAB11843" /db_xref="GOA:P37563" /db_xref="InterPro:IPR011063" /db_xref="InterPro:IPR012094" /db_xref="InterPro:IPR012795" /db_xref="InterPro:IPR012796" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR015262" /db_xref="InterPro:IPR020825" /db_xref="SubtiList:BG10130" /db_xref="UniProtKB/Swiss-Prot:P37563" /translation="MKSVKDFLNKHNLTLKGATIIVGVSGGPDSMALLHALHTLCGRS ANVIAAHVDHRFRGAESEEDMRFVQAYCKAEQLVCETAQINVTAYAQEKGLNKQAAAR DCRYQFFEEIMSKHQADYLALAHHGDDQVETMLMKLAKGTLGTGLAGMQPVRRFGTGR IIRPFLTITKEEILHYCHENGLSYRTDESNAKDDYTRNRFRKTVLPFLKQESPDVHKR FQKVSEALTEDEQFLQSLTKDEMNKVITSQSNTSVEINSSQLLALPMPLQRRGVQLIL NYLYENVPSSFSAHHIQQFLDWAENGGPSGVLDFPKGLKVVKSYQTCLFTFEQWQCKN VPFEYQISGAADETAVLPNGYLIEARHYADSPEEHGNAVFITSEKKVRFPLTIRTRKA GDRIKLKGMNGSKKVKDIFIDKKLPLQERDNWPIVTDASGEIIWIPGLKKSIFEDLVI PNSDRIVLQYRQHEKCRGQAKS*" /label="tilS CDS" gene 74520..75938 /gene="tilS" /locus_tag="BSU_00670" /old_locus_tag="BSU00670" /label="tilS gene" promotor_-35 75315..75322 /Source="Nicolas_upshift_promotors" /id="U67" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.721278721278721" /psig="0.999000999001" /xcortree=1885 /SigmaFactorBS="aaatcaattcctctcaattgcttgccctcccgatgCCTTTAC AaagaagaggagttcAACTAATATTAAACTATCTTtatgaaaacgttccatcatcctt t" /listShort="hprT, S38, ftsH, S39, S40, coaX, hslO, yacD" /listLong="cysK, pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="promotor_-35" promotor_-10 75337..75356 /Source="Nicolas_upshift_promotors" /id="U67" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.721278721278721" /psig="0.999000999001" /xcortree=1885 /SigmaFactorBS="aaatcaattcctctcaattgcttgccctcccgatgCCTTTAC AaagaagaggagttcAACTAATATTAAACTATCTTtatgaaaacgttccatcatcctt t" /listShort="hprT, S38, ftsH, S39, S40, coaX, hslO, yacD" /listLong="cysK, pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="promotor_-10" upshifts 75340 /Source="Nicolas_upshifts" /id="U67" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.721278721278721" /psig="0.999000999001" /xcortree=1885 /SigmaFactorBS="aaatcaattcctctcaattgcttgccctcccgatgCCTTTAC AaagaagaggagttcAACTAATATTAAACTATCTTtatgaaaacgttccatcatcctt t" /listShort="hprT, S38, ftsH, S39, S40, coaX, hslO, yacD" /listLong="cysK, pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="upshifts" downshifts complement(75933) /Source="Nicolas_upshifts" /id="D33" /incds=0 /nref=2 /ntot=142 /MaxReadThrough="2.51342" /MaxDrop="2.96272" /score="12.3455896" /energy="-9.1" /TU="NA" /idTUdmin="U68" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" CDS 75935..76477 /gene="hprT" /locus_tag="BSU_00680" /old_locus_tag="BSU00680" /EC_number="2.4.2.8" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:3110131, 6408059, 24001521" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3110131, 6408059, 24001521; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="hypoxanthine-guanine phosphoribosyltransferase" /protein_id="NP_387949.1" /db_xref="EnsemblGenomes-Gn:BSU00680" /db_xref="EnsemblGenomes-Tr:CAB11844" /db_xref="GOA:P37472" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR005904" /db_xref="InterPro:IPR029057" /db_xref="SubtiList:BG10131" /db_xref="UniProtKB/Swiss-Prot:P37472" /translation="MMKHDIEKVLISEEEIQKKVKELGAELTSEYQDTFPLAIGVLKG ALPFMADLIKHIDTYLEMDFMDVSSYGNSTVSSGEVKIIKDLDTSVEGRDILIIEDII DSGLTLSYLVELFRYRKAKSIKIVTLLDKPSGRKADIKADFVGFEVPDAFVVGYGLDY AERYRNLPYIGVLKPAVYES*" /label="hprT CDS" gene 75935..76477 /gene="hprT" /locus_tag="BSU_00680" /old_locus_tag="BSU00680" /label="hprT gene" upshifts complement(76340) /Source="Nicolas_upshifts" /id="U68" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.988011988011988" /psig="0.002997002997003" /xcortree=41 /SigmaFactorBS="aacccactacaaacgcgtcaggaacttcaaaacCGACaaagt ctgctttgatgtCCGCTtttcttccgctcggtttatccaaaagggtaacaatcttaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(76342..76346) /Source="Nicolas_upshift_promotors" /id="U68" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.988011988011988" /psig="0.002997002997003" /xcortree=41 /SigmaFactorBS="aacccactacaaacgcgtcaggaacttcaaaacCGACaaagt ctgctttgatgtCCGCTtttcttccgctcggtttatccaaaagggtaacaatcttaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(76364..76367) /Source="Nicolas_upshift_promotors" /id="U68" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.988011988011988" /psig="0.002997002997003" /xcortree=41 /SigmaFactorBS="aacccactacaaacgcgtcaggaacttcaaaacCGACaaagt ctgctttgatgtCCGCTtttcttccgctcggtttatccaaaagggtaacaatcttaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 76478..76574 /Source="Nicolas_S_feature" /locus_tag="new_76887_76983" /HighExp="Diami, H2O2, dia5, G135, dia15, G150, Paraq, C90, G180, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigEF" /TUshortPSig="0.999, 1, 0.842" /TUlongSig="SigB, SigA" /TUlongPSig="1, 0.99" /label="S38" CDS 76575..78488 /gene="ftsH" /locus_tag="BSU_00690" /old_locus_tag="BSU00690" /EC_number="3.4.24.-" /function="16.9: Replicate" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:9076729, 9084181, 9287010, 9352926, 10851010, 10913836, 12533473, 24001521, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9076729, 9084181, 9287010, 9352926, 10851010, 10913836, 12533473, 24001521, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent cytoplasmic membrane protease" /protein_id="NP_387950.1" /db_xref="EnsemblGenomes-Gn:BSU00690" /db_xref="EnsemblGenomes-Tr:CAB11845" /db_xref="GOA:P37476" /db_xref="InterPro:IPR000642" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR003959" /db_xref="InterPro:IPR003960" /db_xref="InterPro:IPR005936" /db_xref="InterPro:IPR011546" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR037219" /db_xref="SubtiList:BG10132" /db_xref="UniProtKB/Swiss-Prot:P37476" /translation="MNRVFRNTIFYLLILLVVIGVVSYFQTSNPKTENMSYSTFIKNL DDGKVDSVSVQPVRGVYEVKGQLKNYDKDQYFLTHVPEGKGADQIFNALKKTDVKVEP AQETSGWVTFLTTIIPFVIIFILFFFLLNQAQGGGSRVMNFGKSKAKLYTEEKKRVKF KDVAGADEEKQELVEVVEFLKDPRKFAELGARIPKGVLLVGPPGTGKTLLAKACAGEA GVPFFSISGSDFVEMFVGVGASRVRDLFENAKKNAPCLIFIDEIDAVGRQRGAGLGGG HDEREQTLNQLLVEMDGFSANEGIIIIAATNRADILDPALLRPGRFDRQITVDRPDVI GREAVLKVHARNKPLDETVNLKSIAMRTPGFSGADLENLLNEAALVAARQNKKKIDAR DIDEATDRVIAGPAKKSRVISKKERNIVAYHEGGHTVIGLVLDEADMVHKVTIVPRGQ AGGYAVMLPREDRYFQTKPELLDKIVGLLGGRVAEEIIFGEVSTGAHNDFQRATNIAR RMVTEFGMSEKLGPLQFGQSQGGQVFLGRDFNNEQNYSDQIAYEIDQEIQRIIKECYE RAKQILTENRDKLELIAQTLLKVETLDAEQIKHLIDHGTLPERNFSDDEKNDDVKVNI LTKTEEKKDDTKE*" /label="ftsH CDS" gene 76575..78488 /gene="ftsH" /locus_tag="BSU_00690" /old_locus_tag="BSU00690" /label="ftsH gene" downshifts 78486 /Source="Nicolas_upshifts" /id="D34" /incds=0 /nref=187 /ntot=269 /MaxReadThrough="5.00908" /MaxDrop="8.91482" /score="38.4132386" /energy="-12.9" /TU="U66,U67" /idTUdmin="U64" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(78525..78529) /Source="Nicolas_upshift_promotors" /id="U69" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.955044955044955" /psig="0.000999000999001" /xcortree=66 /SigmaFactorBS="aaatcgataccagaattggatgattgtaaaagccgcagctga gccaatcatttacataaaaaaaCTGCCagcgtcagccggcagtttttttagaaagaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 78531..78616 /Source="Nicolas_S_feature" /locus_tag="new_78940_79025" /HighExp="H2O2, G180, G135, dia15, Paraq, G150, Oxctl, Diami, Cold, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S39" upshifts complement(78533) /Source="Nicolas_upshifts" /id="U69" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.955044955044955" /psig="0.000999000999001" /xcortree=66 /SigmaFactorBS="aaatcgataccagaattggatgattgtaaaagccgcagctga gccaatcatttacataaaaaaaCTGCCagcgtcagccggcagtttttttagaaagaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 78593..78600 /Source="Nicolas_upshift_promotors" /id="U70" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig=1 /xcortree=1864 /SigmaFactorBS="gcggcttttacaatcatccaattctggtatcgattTGTTTAC AaatgagccgctgaTCGTGTATGGTATTGTAGAAtgtttgtaaaaagtaaagtagaga a" /listShort="S40, coaX, hslO, yacD, cysK" /listLong="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="promotor_-35" promotor_-10 78614..78633 /Source="Nicolas_upshift_promotors" /id="U70" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig=1 /xcortree=1864 /SigmaFactorBS="gcggcttttacaatcatccaattctggtatcgattTGTTTAC AaatgagccgctgaTCGTGTATGGTATTGTAGAAtgtttgtaaaaagtaaagtagaga a" /listShort="S40, coaX, hslO, yacD, cysK" /listLong="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="promotor_-10" S_feature 78618..78682 /Source="Nicolas_S_feature" /locus_tag="new_79027_79091" /HighExp="dia5, H2O2, dia15, Paraq, Diami, G180, LBGexp, Oxctl, G135, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S40" upshifts 78618 /Source="Nicolas_upshifts" /id="U70" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig=1 /xcortree=1864 /SigmaFactorBS="gcggcttttacaatcatccaattctggtatcgattTGTTTAC AaatgagccgctgaTCGTGTATGGTATTGTAGAAtgtttgtaaaaagtaaagtagaga a" /listShort="S40, coaX, hslO, yacD, cysK" /listLong="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="upshifts" CDS 78683..79459 /gene="coaX" /locus_tag="BSU_00700" /old_locus_tag="BSU00700" /EC_number="2.7.1.33" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15795230, 16905099, 24784177" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15795230, 16905099, 24784177; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pantothenate kinase type III" /protein_id="NP_387951.2" /db_xref="EnsemblGenomes-Gn:BSU00700" /db_xref="EnsemblGenomes-Tr:CAB11846" /db_xref="GOA:P37564" /db_xref="InterPro:IPR004619" /db_xref="SubtiList:BG10133" /db_xref="UniProtKB/Swiss-Prot:P37564" /translation="MLLVIDVGNTNTVLGVYHDGKLEYHWRIETSRHKTEDEFGMILR SLFDHSGLMFEQIDGIIISSVVPPIMFALERMCTKYFHIEPQIVGPGMKTGLNIKYDN PKEVGADRIVNAVAAIHLYGNPLIVVDFGTATTYCYIDENKQYMGGAIAPGITISTEA LYSRAAKLPRIEITRPDNIIGKNTVSAMQSGILFGYVGQVEGIVKRMKWQAKQEPKVI ATGGLAPLIANESDCIDIVDPFLTLKGLELIYERNRVGSV*" /label="coaX CDS" gene 78683..79459 /gene="coaX" /locus_tag="BSU_00700" /old_locus_tag="BSU00700" /label="coaX gene" CDS 79471..80346 /gene="hslO" /locus_tag="BSU_00710" /old_locus_tag="BSU00710" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11323724, 15023991; Product type f: factor" /codon_start=1 /transl_table=11 /product="disulfide bond chaperone (heat shock protein HSP33)" /protein_id="NP_387952.1" /db_xref="EnsemblGenomes-Gn:BSU00710" /db_xref="EnsemblGenomes-Tr:CAB11847" /db_xref="GOA:P37565" /db_xref="InterPro:IPR000397" /db_xref="InterPro:IPR016153" /db_xref="InterPro:IPR016154" /db_xref="PDB:1VZY" /db_xref="SubtiList:BG10134" /db_xref="UniProtKB/Swiss-Prot:P37565" /translation="MDYLVKALAYDGKVRAYAARTTDMVNEGQRRHGTWPTASAALGR TMTASLMLGAMLKGDDKLTVKIEGGGPIGAIVADANAKGEVRAYVSNPQVHFDLNEQG KLDVRRAVGTNGTLSVVKDLGLREFFTGQVEIVSGELGDDFTYYLVSSEQVPSSVGVG VLVNPDNTILAAGGFIIQLMPGTDDETITKIEQRLSQVEPISKLIQKGLTPEEILEEV LGEKPEILETMPVRFHCPCSKERFETAILGLGKKEIQDMIEEDGQAEAVCHFCNEKYL FTKEELEGLRDQTTR*" /label="hslO CDS" gene 79471..80346 /gene="hslO" /locus_tag="BSU_00710" /old_locus_tag="BSU00710" /label="hslO gene" CDS 80393..81286 /gene="yacD" /locus_tag="BSU_00720" /old_locus_tag="BSU00720" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15187182, 15856219; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative protein chaperone accessory lipoproteinfactor" /protein_id="NP_387953.1" /db_xref="EnsemblGenomes-Gn:BSU00720" /db_xref="EnsemblGenomes-Tr:CAB11848" /db_xref="GOA:P37566" /db_xref="InterPro:IPR000297" /db_xref="InterPro:IPR023058" /db_xref="InterPro:IPR027304" /db_xref="SubtiList:BG10135" /db_xref="UniProtKB/Swiss-Prot:P37566" /translation="MKSRTIWTIILGALLVCCIAVAYTLTKSQAGASSSGESIATIGG KSVTREEWLKEMEDQYGKSTLEDMINVRVVEQLAKKNKLKISKSEVDREFLLIKAVNN SFYEDEHTTEKEWKDQIRYNILLEDLLTRDIDISNKELESFYNKNKELYQFDDSYRIR HIVVKDEEEAREVLKELKGGSSFEAVAAERSTDRYTSPYGGDLGFVTEASDNIPSAYI EEAKTLKEDEWSQEPIKVSNGYAIIQLKEKLKARTFSFDEVKDQIRRQIAMDQLGDKA TVKTLWKEADVSWFYGEKSTK*" /label="yacD CDS" gene 80393..81286 /gene="yacD" /locus_tag="BSU_00720" /old_locus_tag="BSU00720" /label="yacD gene" promotor_-35 81016..81021 /Source="Nicolas_upshift_promotors" /id="U71" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1220 /SigmaFactorBS="catcaccatacggcggagatttaggttttgtcacagaGGCAT CagacaacattccatcaGCATACATTGAAGAGGCGAaaacactcaaagaggatgaatg g" /listShort="cysK" /listLong="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /label="promotor_-35" promotor_-10 81038..81056 /Source="Nicolas_upshift_promotors" /id="U71" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1220 /SigmaFactorBS="catcaccatacggcggagatttaggttttgtcacagaGGCAT CagacaacattccatcaGCATACATTGAAGAGGCGAaaacactcaaagaggatgaatg g" /listShort="cysK" /listLong="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /label="promotor_-10" upshifts 81039 /Source="Nicolas_upshifts" /id="U71" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1220 /SigmaFactorBS="catcaccatacggcggagatttaggttttgtcacagaGGCAT CagacaacattccatcaGCATACATTGAAGAGGCGAaaacactcaaagaggatgaatg g" /listShort="cysK" /listLong="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /label="upshifts" promotor_-35 81285..81292 /Source="Nicolas_upshift_promotors" /id="U72" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.844155844155844" /psig=1 /xcortree=1740 /SigmaFactorBS="tcttggttttatggggaaaaaagtactaagtGATTGACAaaa aattttgaaatTGATAGATTATATACATAATaccaatacaaatagtcggaaattgagg t" /listShort="cysK, pabB, pabA, pabC, sul" /listLong="folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="promotor_-35" promotor_-10 81307..81326 /Source="Nicolas_upshift_promotors" /id="U72" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.844155844155844" /psig=1 /xcortree=1740 /SigmaFactorBS="tcttggttttatggggaaaaaagtactaagtGATTGACAaaa aattttgaaatTGATAGATTATATACATAATaccaatacaaatagtcggaaattgagg t" /listShort="cysK, pabB, pabA, pabC, sul" /listLong="folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="promotor_-10" upshifts 81314 /Source="Nicolas_upshifts" /id="U72" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.844155844155844" /psig=1 /xcortree=1740 /SigmaFactorBS="tcttggttttatggggaaaaaagtactaagtGATTGACAaaa aattttgaaatTGATAGATTATATACATAATaccaatacaaatagtcggaaattgagg t" /listShort="cysK, pabB, pabA, pabC, sul" /listLong="folB, folK, yazB, dusB, S42, lysS, S43, rrnJ-16S" /label="upshifts" CDS 81362..82288 /gene="cysK" /locus_tag="BSU_00730" /old_locus_tag="BSU00730" /EC_number="2.5.1.47" /EC_number="4.4.1.1" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11390694, 15760717, 16267287, 16513748, 17056751, 18974048" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11390694, 15760717, 16267287, 16513748, 17056751, 18974048; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cysteine synthase" /protein_id="NP_387954.1" /db_xref="EnsemblGenomes-Gn:BSU00730" /db_xref="EnsemblGenomes-Tr:CAB11849" /db_xref="GOA:P37887" /db_xref="InterPro:IPR001216" /db_xref="InterPro:IPR001926" /db_xref="InterPro:IPR005856" /db_xref="InterPro:IPR005859" /db_xref="InterPro:IPR036052" /db_xref="SubtiList:BG10136" /db_xref="UniProtKB/Swiss-Prot:P37887" /translation="MVRVANSITELIGNTPIVKLNRLADENSADVYLKLEYMNPGSSV KDRIGLAMIEAAEKEGKLKAGNTIIEPTSGNTGIGLAMVAAAKGLKAILVMPDTMSME RRNLLRAYGAELVLTPGAEGMKGAIKKAEELAEKHGYFVPQQFNNPSNPEIHRQTTGK EIVEQFGDDQLDAFVAGIGTGGTITGAGEVLKEAYPSIKIYAVEPSDSPVLSGGKPGP HKIQGIGAGFVPDILNTEVYDEIFPVKNEEAFEYARRAAREEGILGGISSGAAIYAAL QVAKKLGKGKKVLAIIPSNGERYLSTPLYQFD*" /label="cysK CDS" gene 81362..82288 /gene="cysK" /locus_tag="BSU_00730" /old_locus_tag="BSU00730" /label="cysK gene" downshifts 82281 /Source="Nicolas_upshifts" /id="D35" /incds=0 /nref=156 /ntot=259 /MaxReadThrough="5.90023" /MaxDrop="5.38596" /score="41.7897705" /energy="-11.4" /TU="U72" /idTUdmin="U70" /TUdmin=10 /isTUend="TRUE" /label="downshifts" promotor_-35 82335..82343 /Source="Nicolas_upshift_promotors" /id="U73" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.787212787212787" /psig="0.787212787212787" /xcortree=1723 /SigmaFactorBS="aactcccggttcgccgggagtttttttatatttcgtGCATCA AATatgccatgtctgcGACGAATGTtattcttggaagagaaattcacttttttcacta a" /listShort="pabB" /listLong="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /label="promotor_-35" promotor_-10 82357..82365 /Source="Nicolas_upshift_promotors" /id="U73" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.787212787212787" /psig="0.787212787212787" /xcortree=1723 /SigmaFactorBS="aactcccggttcgccgggagtttttttatatttcgtGCATCA AATatgccatgtctgcGACGAATGTtattcttggaagagaaattcacttttttcacta a" /listShort="pabB" /listLong="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /label="promotor_-10" upshifts 82359 /Source="Nicolas_upshifts" /id="U73" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.787212787212787" /psig="0.787212787212787" /xcortree=1723 /SigmaFactorBS="aactcccggttcgccgggagtttttttatatttcgtGCATCA AATatgccatgtctgcGACGAATGTtattcttggaagagaaattcacttttttcacta a" /listShort="pabB" /listLong="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /label="upshifts" promotor_-35 82387..82390 /Source="Nicolas_upshift_promotors" /id="U74" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.7992007992008" /psig="0.998001998001998" /xcortree=2267 /SigmaFactorBS="gcgacgaatgttattcttggaagagaaattcaCTTTtttcac taacaacaTTGCTTTACAATTAAAAACAagtaaaaaagaaaatagaggaatgatacaa a" /listShort="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /listLong="S43, rrnJ-16S" /label="promotor_-35" promotor_-10 82405..82424 /Source="Nicolas_upshift_promotors" /id="U74" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.7992007992008" /psig="0.998001998001998" /xcortree=2267 /SigmaFactorBS="gcgacgaatgttattcttggaagagaaattcaCTTTtttcac taacaacaTTGCTTTACAATTAAAAACAagtaaaaaagaaaatagaggaatgatacaa a" /listShort="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /listLong="S43, rrnJ-16S" /label="promotor_-10" upshifts 82415 /Source="Nicolas_upshifts" /id="U74" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.7992007992008" /psig="0.998001998001998" /xcortree=2267 /SigmaFactorBS="gcgacgaatgttattcttggaagagaaattcaCTTTtttcac taacaacaTTGCTTTACAATTAAAAACAagtaaaaaagaaaatagaggaatgatacaa a" /listShort="pabB, pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /listLong="S43, rrnJ-16S" /label="upshifts" CDS 82455..83867 /gene="pabB" /locus_tag="BSU_00740" /old_locus_tag="BSU00740" /EC_number="2.6.1.85" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2123867, 9084182, 16605270, 17114263, 25288929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="4-amino-4-deoxychorismate synthase (para-aminobenzoate synthase)" /protein_id="NP_387955.1" /db_xref="EnsemblGenomes-Gn:BSU00740" /db_xref="EnsemblGenomes-Tr:CAB11850" /db_xref="GOA:P28820" /db_xref="InterPro:IPR005801" /db_xref="InterPro:IPR006805" /db_xref="InterPro:IPR015890" /db_xref="InterPro:IPR019999" /db_xref="SubtiList:BG10137" /db_xref="UniProtKB/Swiss-Prot:P28820" /translation="MAQRRPAGKKIPFQKDSFLQQFEKLAQSRKHHVLLESARGGRYS IAGLDPIATVKGKDGITTIKHGDEMLFKEGDPLRAFHSWFKTLETETNHEFPDFQGGA IGFLSYDYARYIENFKMLSLDDLETPDIYFLVFDDIAVYDHQEESLWLITHVNGSDQE TADVKLSELEQMWLTELPAVTSREMKPETAGSFAAPFTEDGFSQAVEKIKQYIASGDV FQVNLSIRQSQSLSVHPYQIYKTLREVNPSPYMAYLETPDFQIICGSPELLVSKKGKL LETRPIAGTRSRGKTNEEDEALANELIHNEKERAEHVMLVDLERNDLGRVSRYGSVRV NEFMAIEKYSHVMHIVSNVQGELQDGYDAVDIIHAVFPGGTITGAPKVRTMEIIEELE PTRRGLYTGSIGWFGYNHDLQFNIVIRTIYATGGQAFMQSGAGVVIDSVPKHEYKESF KKAFAMQRALELSEEETKIR*" /label="pabB CDS" gene 82455..83867 /gene="pabB" /locus_tag="BSU_00740" /old_locus_tag="BSU00740" /label="pabB gene" promotor_-35 83257..83259 /Source="Nicolas_upshift_promotors" /id="U75" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.416583416583417" /psig="0.621378621378621" /xcortree=608 /SigmaFactorBS="cctgatttccaaatcatttgcggatcgcctgaacTGCttgtc agcaaaaagggcAAGCTATTAGAGACGAGACcgattgcgggcacccgttccagaggga a" /GFF_Attribute="listShort" /listLong="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /label="promotor_-35" promotor_-10 83277..83295 /Source="Nicolas_upshift_promotors" /id="U75" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.416583416583417" /psig="0.621378621378621" /xcortree=608 /SigmaFactorBS="cctgatttccaaatcatttgcggatcgcctgaacTGCttgtc agcaaaaagggcAAGCTATTAGAGACGAGACcgattgcgggcacccgttccagaggga a" /GFF_Attribute="listShort" /listLong="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /label="promotor_-10" upshifts 83283 /Source="Nicolas_upshifts" /id="U75" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.416583416583417" /psig="0.621378621378621" /xcortree=608 /SigmaFactorBS="cctgatttccaaatcatttgcggatcgcctgaacTGCttgtc agcaaaaagggcAAGCTATTAGAGACGAGACcgattgcgggcacccgttccagaggga a" /GFF_Attribute="listShort" /listLong="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /label="upshifts" promotor_-35 83624..83631 /Source="Nicolas_upshift_promotors" /id="U76" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.57942057942058" /psig="0.998001998001998" /xcortree=2212 /SigmaFactorBS="agtaagaacgatggaaattatagaagaACTTGAGCcgacacg ccgagGGCTTTATACTGGATCTATAggatggtttggatataatcacgatctgcagttt a" /listShort="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /listLong="S43, rrnJ-16S" /label="promotor_-35" promotor_-10 83644..83663 /Source="Nicolas_upshift_promotors" /id="U76" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.57942057942058" /psig="0.998001998001998" /xcortree=2212 /SigmaFactorBS="agtaagaacgatggaaattatagaagaACTTGAGCcgacacg ccgagGGCTTTATACTGGATCTATAggatggtttggatataatcacgatctgcagttt a" /listShort="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /listLong="S43, rrnJ-16S" /label="promotor_-10" upshifts 83657 /Source="Nicolas_upshifts" /id="U76" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.57942057942058" /psig="0.998001998001998" /xcortree=2212 /SigmaFactorBS="agtaagaacgatggaaattatagaagaACTTGAGCcgacacg ccgagGGCTTTATACTGGATCTATAggatggtttggatataatcacgatctgcagttt a" /listShort="pabA, pabC, sul, folB, folK, yazB, dusB, S42, lysS" /listLong="S43, rrnJ-16S" /label="upshifts" CDS 83881..84465 /gene="pabA" /locus_tag="BSU_00750" /old_locus_tag="BSU00750" /EC_number="2.6.1.85" /EC_number="4.1.3.27" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9098056, 16605270, 17114263, 24847778; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="4-amino-4-deoxychorismate synthase; anthranilatesynthase (subunit II)" /protein_id="NP_387956.1" /db_xref="EnsemblGenomes-Gn:BSU00750" /db_xref="EnsemblGenomes-Tr:CAB11851" /db_xref="GOA:P28819" /db_xref="InterPro:IPR006221" /db_xref="InterPro:IPR017926" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG10138" /db_xref="UniProtKB/Swiss-Prot:P28819" /translation="MILMIDNYDSFTYNLVQYLGELGEELVVKRNDSITIDEIEELSP DFLMISPGPCSPDEAGISLEAIKHFAGKIPIFGVCLGHQSIAQVFGGDVVRAERLMHG KTSDIEHDGKTIFEGLKNPLVATRYHSLIVKPETLPSCFTVTAQTKEGEIMAIRHNDL PIEGVQFHPESIMTSFGKEMLRNFIETYRKEVIA*" /label="pabA CDS" gene 83881..84465 /gene="pabA" /locus_tag="BSU_00750" /old_locus_tag="BSU00750" /label="pabA gene" CDS 84465..85346 /gene="pabC" /locus_tag="BSU_00760" /old_locus_tag="BSU00760" /EC_number="4.1.3.38" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10876155, 1644759, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="4-amino-4-deoxychorismate pyruvate-lyase" /protein_id="NP_387957.1" /db_xref="EnsemblGenomes-Gn:BSU00760" /db_xref="EnsemblGenomes-Tr:CAB11852" /db_xref="GOA:P28821" /db_xref="InterPro:IPR001544" /db_xref="InterPro:IPR017824" /db_xref="InterPro:IPR018300" /db_xref="InterPro:IPR036038" /db_xref="SubtiList:BG10139" /db_xref="UniProtKB/Swiss-Prot:P28821" /translation="MIYVNGRYMEEKDAVLSPFDHGFLYGIGVFETFRLYEGCPFLLD WHIERLERALKDLQIEYTVSKHEILEMLDKLLKLNDIKDGNARVRLNISAGISDKGFV AQTYDKPTVLCFVNQLKPESLPLQKEGKVLSIRRNTPEGSFRLKSHHYLNNMYAKREI GNDPRVEGIFLTEDGAVAEGIISNVFWRKGRCIYTPSLDTGILDGVTRRFIIENAKDI GLELKTGRYELEALLTADEAWMTNSVLEIIPFTKIEEVNYGSQSGEATSALQLLYKKE IKNMIHEKGGRAWRSTQ*" /label="pabC CDS" gene 84465..85346 /gene="pabC" /locus_tag="BSU_00760" /old_locus_tag="BSU00760" /label="pabC gene" CDS 85328..86185 /gene="folP" /locus_tag="BSU_00770" /old_locus_tag="BSU00770" /EC_number="2.5.1.15" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2123867, 11007651; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydropteroate synthase" /protein_id="NP_387958.1" /db_xref="EnsemblGenomes-Gn:BSU00770" /db_xref="EnsemblGenomes-Tr:CAB11853" /db_xref="GOA:P28822" /db_xref="InterPro:IPR000489" /db_xref="InterPro:IPR006390" /db_xref="InterPro:IPR011005" /db_xref="SubtiList:BG10140" /db_xref="UniProtKB/Swiss-Prot:P28822" /translation="MAQHTIDQTQVIHTKPSALSYKEKTLVMGILNVTPDSFSDGGKY DSLDKALLHAKEMIDDGAHIIDIGGESTRPGAECVSEDEEMSRVIPVIERITKELGVP ISVDTYKASVADEAVKAGASIINDIWGAKHDPKMASVAAEHNVPIVLMHNRPERNYND LLPDMLSDLMESVKIAVEAGVDEKNIILDPGIGFAKTYHDNLAVMNKLEIFSGLGYPV LLATSRKRFIGRVLDLPPEERAEGTGATVCLGIQKGCDIVRVHDVKQIARMAKMMDAM LNKGGVHHG*" /label="folP CDS" gene 85328..86185 /gene="folP" /locus_tag="BSU_00770" /old_locus_tag="BSU00770" /label="folP gene" CDS 86178..86540 /gene="folB" /locus_tag="BSU_00780" /old_locus_tag="BSU00780" /EC_number="4.1.2.25" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16188473, 17176045, 17388809; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydroneopterin aldolase" /protein_id="NP_387959.1" /db_xref="EnsemblGenomes-Gn:BSU00780" /db_xref="EnsemblGenomes-Tr:CAB11854" /db_xref="GOA:P28823" /db_xref="InterPro:IPR006156" /db_xref="InterPro:IPR006157" /db_xref="SubtiList:BG10141" /db_xref="UniProtKB/Swiss-Prot:P28823" /translation="MDKVYVEGMEFYGYHGVFTEENKLGQRFKVDLTAELDLSKAGQT DDLEQTINYAELYHVCKDIVEGEPVKLVETLAERIAGTVLGKFQPVQQCTVKVIKPDP PIPGHYKSVAIEITRKKS*" /label="folB CDS" gene 86178..86540 /gene="folB" /locus_tag="BSU_00780" /old_locus_tag="BSU00780" /label="folB gene" CDS 86537..87040 /gene="folK" /locus_tag="BSU_00790" /old_locus_tag="BSU00790" /EC_number="2.7.6.3" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17029412; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase" /protein_id="NP_387960.1" /db_xref="EnsemblGenomes-Gn:BSU00790" /db_xref="EnsemblGenomes-Tr:CAB11855" /db_xref="GOA:P29252" /db_xref="InterPro:IPR000550" /db_xref="InterPro:IPR035907" /db_xref="SubtiList:BG10142" /db_xref="UniProtKB/Swiss-Prot:P29252" /translation="MNNIAYIALGSNIGDRETYLRQAVALLHQHAAVTVTKVSSIYET DPVGYEDQAQFLNMAVEIKTSLNPFELLELTQQIENELGRTREVRWGPRTADLDILLF NRENIETEQLIVPHPRMYERLFVLAPLAEICQQVEKEATSAETDQEGVRVWKQKSGVD EFVHSES*" /label="folK CDS" gene 86537..87040 /gene="folK" /locus_tag="BSU_00790" /old_locus_tag="BSU00790" /label="folK gene" CDS 86992..87201 /gene="yazB" /locus_tag="BSU_00800" /old_locus_tag="BSU00800" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_387961.1" /db_xref="EnsemblGenomes-Gn:BSU00800" /db_xref="EnsemblGenomes-Tr:CAB11856" /db_xref="GOA:O31417" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010982" /db_xref="SubtiList:BG12701" /db_xref="UniProtKB/Swiss-Prot:O31417" /translation="MEAEIWGRRIRAFRKLKGYTQEGFAKALGISVSILGEIERGNRL PSAAIIQDAADVLNISADELAPPEK*" /label="yazB CDS" gene 86992..87201 /gene="yazB" /locus_tag="BSU_00800" /old_locus_tag="BSU00800" /label="yazB gene" CDS 87225..88226 /gene="dusB" /locus_tag="BSU_00810" /old_locus_tag="BSU00810" /EC_number="1.-.-.-" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11983710, 15698474, 26112661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA-dihydrouridine synthase B" /protein_id="NP_387962.1" /db_xref="EnsemblGenomes-Gn:BSU00810" /db_xref="EnsemblGenomes-Tr:CAB11857" /db_xref="GOA:P37567" /db_xref="InterPro:IPR001269" /db_xref="InterPro:IPR004652" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR018517" /db_xref="InterPro:IPR024036" /db_xref="InterPro:IPR035587" /db_xref="SubtiList:BG10143" /db_xref="UniProtKB/Swiss-Prot:P37567" /translation="MFKIGDIQLKNRVVLAPMAGVCNSAFRLTVKEFGAGLVCAEMVS DKAILYNNARTMGMLYIDEREKPLSLQIFGGKKETLVEAAKFVDQNTTADIIDINMGC PVPKITKCDAGAKWLLDPDKIYEMVSAVVDAVNKPVTVKMRMGWDEDHIFAVKNAQAV ERAGGKAVALHGRTRVQMYEGTANWDIIKEVKQSVSIPVIGNGDVKTPQDAKRMLDET GVDGVMIGRAALGNPWMIYRTVQYLETGKLKEEPQVREKMAVCKLHLDRLIDLKGENV AVREMRKHAAWYLKGVKGNANVRNEINHCETREEFVQLLDAFTVEVEAKELQNAKVG* " /label="dusB CDS" gene 87225..88226 /gene="dusB" /locus_tag="BSU_00810" /old_locus_tag="BSU00810" /label="dusB gene" S_feature complement(87641..89157) /Source="Nicolas_S_feature" /locus_tag="new_88050_89566_c" /HighExp="LoTm, C30, S6, S8, S5, S7, S3, S4, C90, G135" /AntisenseName="dusB" /AntisenseCor="-0.60218706634778196" /AntisenseRegPval="-27.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S41" S_feature 88227..88317 /Source="Nicolas_S_feature" /locus_tag="new_88636_88726" /HighExp="H2O2, G180, G150, Paraq, G135, Oxctl, Diami, C30, LBGexp, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 0.998" /TUlongSig="SigA, SigI, SigA, SigEF, SigA, SigA, SigA" /TUlongPSig="0.621, 0.787, 1, 0.995, 1, 0.999, 1" /label="S42" CDS 88318..89817 /gene="lysS" /locus_tag="BSU_00820" /old_locus_tag="BSU00820" /EC_number="6.1.1.6" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14623972, 20649968" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14623972, 20649968; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="lysyl-tRNA synthetase" /protein_id="NP_387963.1" /db_xref="EnsemblGenomes-Gn:BSU00820" /db_xref="EnsemblGenomes-Tr:CAB11858" /db_xref="GOA:P37477" /db_xref="InterPro:IPR002313" /db_xref="InterPro:IPR004364" /db_xref="InterPro:IPR004365" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR018149" /db_xref="InterPro:IPR034762" /db_xref="SubtiList:BG10144" /db_xref="UniProtKB/Swiss-Prot:P37477" /translation="MSQEEHNHEELNDQLQVRRDKMNQLRDNGIDPFGARFERTHQSQ EVISAYQDLTKEELEEKAIEVTIAGRMMTKRGKGKAGFAHLQDLEGQIQIYVRKDSVG DDQYEIFKSSDLGDLIGVTGKVFKTNVGELSVKATSFELLTKALRPLPDKYHGLKDVE QRYRQRYLDLIVNPDSKHTFITRSKIIQAMRRYLDDHGYLEVETPTMHSIPGGASARP FITHHNALDIPLYMRIAIELHLKRLIVGGLEKVYEIGRVFRNEGVSTRHNPEFTMIEL YEAYADYKDIMSLTENLVAHIAQEVLGTTTIQYGEEQIDLKPEWKRIHMVDAVKEATG VDFWEEVTVEQAREYAKEHEVEIKDSMTVGHIINEFFEQKIEETLIQPTFIYGHPVEI SPLAKKNPEDPRFTDRFELFIVGREHANAFTELNDPIDQRERFEAQLKEREAGNDEAH LMDEDFVEALEYGMPPTGGLGIGIDRLVMLLTNAPSIRDVLLFPQMRQR*" /label="lysS CDS" gene 88318..89817 /gene="lysS" /locus_tag="BSU_00820" /old_locus_tag="BSU00820" /label="lysS gene" promotor_-10 complement(89141..89159) /Source="Nicolas_upshift_promotors" /id="U77" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1081 /SigmaFactorBS="ttcttgggcgatatgagcgacaaggttttcagttaagCTCAT GatatctttatagtccGCATATGCTTCATATAACTcaatcattgtaaattcagggtta t" /listShort="S41" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(89157) /Source="Nicolas_upshifts" /id="U77" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1081 /SigmaFactorBS="ttcttgggcgatatgagcgacaaggttttcagttaagCTCAT GatatctttatagtccGCATATGCTTCATATAACTcaatcattgtaaattcagggtta t" /listShort="S41" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(89175..89180) /Source="Nicolas_upshift_promotors" /id="U77" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1081 /SigmaFactorBS="ttcttgggcgatatgagcgacaaggttttcagttaagCTCAT GatatctttatagtccGCATATGCTTCATATAACTcaatcattgtaaattcagggtta t" /listShort="S41" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 89798 /Source="Nicolas_upshifts" /id="D36" /incds=0 /nref=104 /ntot=219 /MaxReadThrough="4.49559" /MaxDrop="4.89484" /score="4.33485487" /energy="-18.1" /TU="U76" /idTUdmin="U74" /TUdmin=3 /isTUend="TRUE" /label="downshifts" promotor_-35 89893..89900 /Source="Nicolas_upshift_promotors" /id="U78" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2623 /SigmaFactorBS="gatgccgctctttttaaatcccttagtatttcttcaaaaaaa ctATTGCACTattatttactaggTGGTATATTATTATTCGTTGccgctaaacaaggcg a" /listShort="S43, rrnJ-16S, rrnJ-23S, rrnJ-5S, trnJ-Val, trnJ-Thr, trnJ-Lys, trnJ-Leu1, trnJ-Gly, trnJ-Leu2, trnJ-Arg, trnJ-Pro" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 89909..90126 /Source="Nicolas_S_feature" /locus_tag="new_90318_90535" /HighExp="LBGstat, H2O2, Oxctl, Diami, dia15, Paraq, MG 25, Heat, MG 15, UNK1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA, SigA, SigA, SigA, SigA" /TUlongPSig="0.998, 0.998, 1, 1, 0.999, 1" /label="S43" upshifts 89909 /Source="Nicolas_upshifts" /id="U78" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2623 /SigmaFactorBS="gatgccgctctttttaaatcccttagtatttcttcaaaaaaa ctATTGCACTattatttactaggTGGTATATTATTATTCGTTGccgctaaacaaggcg a" /listShort="S43, rrnJ-16S, rrnJ-23S, rrnJ-5S, trnJ-Val, trnJ-Thr, trnJ-Lys, trnJ-Leu1, trnJ-Gly, trnJ-Leu2, trnJ-Arg, trnJ-Pro" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 89914..89933 /Source="Nicolas_upshift_promotors" /id="U78" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2623 /SigmaFactorBS="gatgccgctctttttaaatcccttagtatttcttcaaaaaaa ctATTGCACTattatttactaggTGGTATATTATTATTCGTTGccgctaaacaaggcg a" /listShort="S43, rrnJ-16S, rrnJ-23S, rrnJ-5S, trnJ-Val, trnJ-Thr, trnJ-Lys, trnJ-Leu1, trnJ-Gly, trnJ-Leu2, trnJ-Arg, trnJ-Pro" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(89959) /Source="Nicolas_upshifts" /id="D37" /incds=0 /nref=3 /ntot=51 /MaxReadThrough="3.16217" /MaxDrop="5.0092" /score="18.6635354" /energy="-16.9" /TU="NA" /idTUdmin="U77" /TUdmin="-2288" /isTUend="FALSE" /label="downshifts" rRNA 90127..91680 /gene="rrnJ-16S" /locus_tag="BSU_rRNA_6" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnJ-16S rRNA" gene 90127..91680 /gene="rrnJ-16S" /locus_tag="BSU_rRNA_6" /label="rrnJ-16S gene" rRNA 91845..94772 /gene="rrnJ-23S" /locus_tag="BSU_rRNA_7" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnJ-23S rRNA" gene 91845..94772 /gene="rrnJ-23S" /locus_tag="BSU_rRNA_7" /label="rrnJ-23S gene" rRNA 94828..94945 /gene="rrnJ-5S" /locus_tag="BSU_rRNA_8" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnJ-5S rRNA" gene 94828..94945 /gene="rrnJ-5S" /locus_tag="BSU_rRNA_8" /label="rrnJ-5S gene" tRNA 94966..95041 /gene="trnJ-Val" /locus_tag="BSU_tRNA_12" /product="tRNA-Val" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Val(UAC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnJ-Val tRNA" gene 94966..95041 /gene="trnJ-Val" /locus_tag="BSU_tRNA_12" /label="trnJ-Val gene" tRNA 95046..95121 /gene="trnJ-Thr" /locus_tag="BSU_tRNA_13" /product="tRNA-Thr" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Thr(UGU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnJ-Thr tRNA" gene 95046..95121 /gene="trnJ-Thr" /locus_tag="BSU_tRNA_13" /label="trnJ-Thr gene" tRNA 95158..95233 /gene="trnJ-Lys" /locus_tag="BSU_tRNA_14" /product="tRNA-Lys" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Lys(UUU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnJ-Lys tRNA" gene 95158..95233 /gene="trnJ-Lys" /locus_tag="BSU_tRNA_14" /label="trnJ-Lys gene" tRNA 95240..95322 /gene="trnJ-Leu1" /locus_tag="BSU_tRNA_15" /product="tRNA-Leu" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Leu(UAG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnJ-Leu1 tRNA" gene 95240..95322 /gene="trnJ-Leu1" /locus_tag="BSU_tRNA_15" /label="trnJ-Leu1 gene" tRNA 95363..95437 /gene="trnJ-Gly" /locus_tag="BSU_tRNA_16" /product="tRNA-Gly" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Gly(GCC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnJ-Gly tRNA" gene 95363..95437 /gene="trnJ-Gly" /locus_tag="BSU_tRNA_16" /label="trnJ-Gly gene" tRNA 95452..95537 /gene="trnJ-Leu2" /locus_tag="BSU_tRNA_17" /product="tRNA-Leu" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Leu(UAA); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnJ-Leu2 tRNA" gene 95452..95537 /gene="trnJ-Leu2" /locus_tag="BSU_tRNA_17" /label="trnJ-Leu2 gene" tRNA 95547..95623 /gene="trnJ-Arg" /locus_tag="BSU_tRNA_18" /product="tRNA-Arg" /inference="profile:tRNAscan:1.23" /note="arginine transfer RNA(ACG); Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 27749819; Product type n : RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnJ-Arg tRNA" gene 95547..95623 /gene="trnJ-Arg" /locus_tag="BSU_tRNA_18" /label="trnJ-Arg gene" tRNA 95651..95727 /gene="trnJ-Pro" /locus_tag="BSU_tRNA_19" /product="tRNA-Pro" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Pro(UGG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnJ-Pro tRNA" gene 95651..95727 /gene="trnJ-Pro" /locus_tag="BSU_tRNA_19" /label="trnJ-Pro gene" tRNA 95737..95812 /gene="trnJ-Ala" /locus_tag="BSU_tRNA_20" /product="tRNA-Ala" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ala(UGC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnJ-Ala tRNA" gene 95737..95812 /gene="trnJ-Ala" /locus_tag="BSU_tRNA_20" /label="trnJ-Ala gene" rRNA 95983..97536 /gene="rrnW-16S" /locus_tag="BSU_rRNA_9" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnW-16S rRNA" gene 95983..97536 /gene="rrnW-16S" /locus_tag="BSU_rRNA_9" /label="rrnW-16S gene" rRNA 97701..100628 /gene="rrnW-23S" /locus_tag="BSU_rRNA_10" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnW-23S rRNA" gene 97701..100628 /gene="rrnW-23S" /locus_tag="BSU_rRNA_10" /label="rrnW-23S gene" rRNA 100684..100802 /gene="rrnW-5S" /locus_tag="BSU_rRNA_11" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnW-5S rRNA" gene 100684..100802 /gene="rrnW-5S" /locus_tag="BSU_rRNA_11" /label="rrnW-5S gene" S_feature 100803..100880 /Source="Nicolas_S_feature" /locus_tag="new_101212_101289" /HighExp="G135, G180, G150, Cold, Paraq, Oxctl, H2O2, C30, BMM, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S44" promotor_-35 100850..100853 /Source="Nicolas_upshift_promotors" /id="U79" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.37962037962038" /psig="0.947052947052947" /xcortree=1441 /SigmaFactorBS="gctgggttttttgtattttggtttattgGTATcataaaattc cacttAACTGTATAATATAATAACTttataccgaattttaaatcagcaatcaggtttt g" /listShort="ctsR, mcsA, mcsB, clpC" /listLong="radA, disA, S45, yacL, ispD, ispF, gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-35" promotor_-10 100869..100888 /Source="Nicolas_upshift_promotors" /id="U79" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.37962037962038" /psig="0.947052947052947" /xcortree=1441 /SigmaFactorBS="gctgggttttttgtattttggtttattgGTATcataaaattc cacttAACTGTATAATATAATAACTttataccgaattttaaatcagcaatcaggtttt g" /listShort="ctsR, mcsA, mcsB, clpC" /listLong="radA, disA, S45, yacL, ispD, ispF, gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-10" upshifts 100882 /Source="Nicolas_upshifts" /id="U79" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.37962037962038" /psig="0.947052947052947" /xcortree=1441 /SigmaFactorBS="gctgggttttttgtattttggtttattgGTATcataaaattc cacttAACTGTATAATATAATAACTttataccgaattttaaatcagcaatcaggtttt g" /listShort="ctsR, mcsA, mcsB, clpC" /listLong="radA, disA, S45, yacL, ispD, ispF, gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="upshifts" promotor_-35 100916..100922 /Source="Nicolas_upshift_promotors" /id="U80" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=150 /SigmaFactorBS="ctttataccgaattttaaatcagcaatcaGGTTTTGtggacc gggaaaaTGGAAATAATGAAGGATAGAgcgagaaagttgaaaattctcgagaaacggc t" /listShort="ctsR, mcsA, mcsB, clpC, radA, disA, S45, yacL, ispD, ispF" /listLong="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /label="promotor_-35" promotor_-10 100936..100955 /Source="Nicolas_upshift_promotors" /id="U80" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=150 /SigmaFactorBS="ctttataccgaattttaaatcagcaatcaGGTTTTGtggacc gggaaaaTGGAAATAATGAAGGATAGAgcgagaaagttgaaaattctcgagaaacggc t" /listShort="ctsR, mcsA, mcsB, clpC, radA, disA, S45, yacL, ispD, ispF" /listLong="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /label="promotor_-10" upshifts 100947 /Source="Nicolas_upshifts" /id="U80" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=150 /SigmaFactorBS="ctttataccgaattttaaatcagcaatcaGGTTTTGtggacc gggaaaaTGGAAATAATGAAGGATAGAgcgagaaagttgaaaattctcgagaaacggc t" /listShort="ctsR, mcsA, mcsB, clpC, radA, disA, S45, yacL, ispD, ispF" /listLong="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /label="upshifts" promotor_-35 100962..100969 /Source="Nicolas_upshift_promotors" /id="U81" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.736263736263736" /psig=1 /xcortree=2024 /SigmaFactorBS="atggaaataatgaaggatagagcgagaAAGTTGAAaattctc gagaaaCGGCTTATAGTAAGATTAAAgtcaaatatagtcaaagtcagtaaaggagggg g" /listShort="ctsR, mcsA, mcsB, clpC, radA, disA, S45, yacL, ispD, ispF" /listLong="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-35" promotor_-10 100983..101002 /Source="Nicolas_upshift_promotors" /id="U81" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.736263736263736" /psig=1 /xcortree=2024 /SigmaFactorBS="atggaaataatgaaggatagagcgagaAAGTTGAAaattctc gagaaaCGGCTTATAGTAAGATTAAAgtcaaatatagtcaaagtcagtaaaggagggg g" /listShort="ctsR, mcsA, mcsB, clpC, radA, disA, S45, yacL, ispD, ispF" /listLong="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-10" upshifts 100995 /Source="Nicolas_upshifts" /id="U81" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.736263736263736" /psig=1 /xcortree=2024 /SigmaFactorBS="atggaaataatgaaggatagagcgagaAAGTTGAAaattctc gagaaaCGGCTTATAGTAAGATTAAAgtcaaatatagtcaaagtcagtaaaggagggg g" /listShort="ctsR, mcsA, mcsB, clpC, radA, disA, S45, yacL, ispD, ispF" /listLong="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="upshifts" CDS 101040..101504 /gene="ctsR" /locus_tag="BSU_00830" /old_locus_tag="BSU00830" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:2120829, 9852015, 11069659, 12618461, 16163393, 20852588, 24465625, 27388279" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2120829, 9852015, 11069659, 12618461, 16163393, 20852588, 24465625, 27388279; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of class III stress genes" /protein_id="NP_387964.1" /db_xref="EnsemblGenomes-Gn:BSU00830" /db_xref="EnsemblGenomes-Tr:CAB11859" /db_xref="GOA:P37568" /db_xref="InterPro:IPR008463" /db_xref="SubtiList:BG10145" /db_xref="UniProtKB/Swiss-Prot:P37568" /translation="MGHNISDIIEQYLKRVLDQNGKEILEIKRSEIADKFQCVPSQIN YVINTRFTSERGYIVESKRGGGGYIRIIKIKMNNEVVLINNIISQINTHLSQAASDDI ILRLLEDKVISEREAKMMVSVMDRSVLHIDLPERDELRARMMKAMLTSLKLK*" /label="ctsR CDS" gene 101040..101504 /gene="ctsR" /locus_tag="BSU_00830" /old_locus_tag="BSU00830" /label="ctsR gene" misc_feature complement(101151..101155) /Source="Nicolas_upshift_promotors" /id="U82" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.811188811188811" /psig="0.0769230769230769" /xcortree=50 /SigmaFactorBS="caacaatatatcctctttcgcttgtaaatctggtgttgatga cataatttatttgggaaggaACGCAttgaaatttatctgcaatttcacttcgtttaat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(101157) /Source="Nicolas_upshifts" /id="U82" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.811188811188811" /psig="0.0769230769230769" /xcortree=50 /SigmaFactorBS="caacaatatatcctctttcgcttgtaaatctggtgttgatga cataatttatttgggaaggaACGCAttgaaatttatctgcaatttcacttcgtttaat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 101518..102075 /gene="mcsA" /locus_tag="BSU_00840" /old_locus_tag="BSU00840" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16163393, 19189946, 24947607" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16163393, 19189946, 24947607; Product type f: factor" /codon_start=1 /transl_table=11 /product="activator of protein kinase McsB" /protein_id="NP_387965.1" /db_xref="EnsemblGenomes-Gn:BSU00840" /db_xref="EnsemblGenomes-Tr:CAB11860" /db_xref="GOA:P37569" /db_xref="InterPro:IPR001943" /db_xref="InterPro:IPR025542" /db_xref="InterPro:IPR029037" /db_xref="InterPro:IPR036876" /db_xref="SubtiList:BG10146" /db_xref="UniProtKB/Swiss-Prot:P37569" /translation="MICQECHERPATFHFTKVVNGEKIEVHICEQCAKENSDSYGISA NQGFSIHNLLSGLLNMDSSFQNAGTQMFSHSEQISACPKCGMTFQQFRKIGRFGCSEC YKTFHSNITPILRKVHSGNTVHAGKIPKRIGGNLHVRRQIDMLKKELESLIHQEEFEN AAHVRDQIRLLEQSLKSTDSEEEQE*" /label="mcsA CDS" gene 101518..102075 /gene="mcsA" /locus_tag="BSU_00840" /old_locus_tag="BSU00840" /label="mcsA gene" CDS 102075..103166 /gene="mcsB" /locus_tag="BSU_00850" /old_locus_tag="BSU00850" /EC_number="2.7.3.3" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16163393, 17380125, 19189946, 21622759, 25610436, 27749819" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16163393, 17380125, 19189946, 21622759, 25610436, 27749819; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="protein arginine kinase" /protein_id="NP_387966.1" /db_xref="EnsemblGenomes-Gn:BSU00850" /db_xref="EnsemblGenomes-Tr:CAB11861" /db_xref="GOA:P37570" /db_xref="InterPro:IPR000749" /db_xref="InterPro:IPR014746" /db_xref="InterPro:IPR022414" /db_xref="InterPro:IPR022415" /db_xref="InterPro:IPR023660" /db_xref="SubtiList:BG10147" /db_xref="UniProtKB/Swiss-Prot:P37570" /translation="MSLKHFIQDALSSWMKQKGPESDIVLSSRIRLARNFEHIRFPTR YSNEEASSIIQQFEDQFSEQEIPGIGKFVLIRMNDAQPLEKRVLVEKHLISPNLTESP FGGCLLSENEEVSVMLNEEDHIRIQCLFPGFQLLEAMKAANQVDDWIEEKVDYAFNEQ RGYLTSCPTNVGTGLRASVMMHLPALVLTRQINRIIPAINQLGLVVRGIYGEGSEAVG NIFQISNQITLGKSEQDIVEDLNSVAAQLIEQERSAREAIYQTSKIELEDRVYRSYGV LSNCRMIESKETAKCLSDVRLGIDLGIIKGLSSNILNELMILTQPGFLQQYSGGALRP NERDIRRAALIRERLHLEMNGKRQEDESI*" /label="mcsB CDS" gene 102075..103166 /gene="mcsB" /locus_tag="BSU_00850" /old_locus_tag="BSU00850" /label="mcsB gene" CDS 103163..105595 /gene="clpC" /locus_tag="BSU_00860" /old_locus_tag="BSU00860" /function="16.6: Maintain" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12354604, 15529410, 16525504, 26735940, 27749819" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354604, 15529410, 16525504, 26735940, 27749819; Product type f: factor" /codon_start=1 /transl_table=11 /product="class III stress response-related ATPase, AAA+ superfamily" /protein_id="NP_387967.1" /db_xref="EnsemblGenomes-Gn:BSU00860" /db_xref="EnsemblGenomes-Tr:CAB11862" /db_xref="GOA:P37571" /db_xref="InterPro:IPR001270" /db_xref="InterPro:IPR001943" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR003959" /db_xref="InterPro:IPR004176" /db_xref="InterPro:IPR018368" /db_xref="InterPro:IPR019489" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR028299" /db_xref="InterPro:IPR036628" /db_xref="PDB:2K77" /db_xref="PDB:2Y1Q" /db_xref="PDB:2Y1R" /db_xref="PDB:3J3R" /db_xref="PDB:3J3S" /db_xref="PDB:3J3T" /db_xref="PDB:3J3U" /db_xref="PDB:3PXG" /db_xref="PDB:3PXI" /db_xref="PDB:5HBN" /db_xref="SubtiList:BG10148" /db_xref="UniProtKB/Swiss-Prot:P37571" /translation="MMFGRFTERAQKVLALAQEEALRLGHNNIGTEHILLGLVREGEG IAAKALQALGLGSEKIQKEVESLIGRGQEMSQTIHYTPRAKKVIELSMDEARKLGHSY VGTEHILLGLIREGEGVAARVLNNLGVSLNKARQQVLQLLGSNETGSSAAGTNSNANT PTLDSLARDLTAIAKEDSLDPVIGRSKEIQRVIEVLSRRTKNNPVLIGEPGVGKTAIA EGLAQQIINNEVPEILRDKRVMTLDMGTVVAGTKYRGEFEDRLKKVMDEIRQAGNIIL FIDELHTLIGAGGAEGAIDASNILKPSLARGELQCIGATTLDEYRKYIEKDAALERRF QPIQVDQPSVDESIQILQGLRDRYEAHHRVSITDDAIEAAVKLSDRYISDRFLPDKAI DLIDEAGSKVRLRSFTTPPNLKELEQKLDEVRKEKDAAVQSQEFEKAASLRDTEQRLR EQVEDTKKSWKEKQGQENSEVTVDDIAMVVSSWTGVPVSKIAQTETDKLLNMENILHS RVIGQDEAVVAVAKAVRRARAGLKDPKRPIGSFIFLGPTGVGKTELARALAESIFGDE ESMIRIDMSEYMEKHSTSRLVGSPPGYVGYDEGGQLTEKVRRKPYSVVLLDEIEKAHP DVFNILLQVLEDGRLTDSKGRTVDFRNTILIMTSNVGASELKRNKYVGFNVQDETQNH KDMKDKVMGELKRAFRPEFINRIDEIIVFHSLEKKHLTEIVSLMSDQLTKRLKEQDLS IELTDAAKAKVAEEGVDLEYGARPLRRAIQKHVEDRLSEELLRGNIHKGQHIVLDVED GEFVVKTTAKTN*" /label="clpC CDS" gene 103163..105595 /gene="clpC" /locus_tag="BSU_00860" /old_locus_tag="BSU00860" /label="clpC gene" downshifts 105590 /Source="Nicolas_upshifts" /id="D38" /incds=0 /nref=57 /ntot=245 /MaxReadThrough="6.69446" /MaxDrop="4.4703" /score="-8.32149463" /energy="-11.7" /TU="U80,U81" /idTUdmin="U79" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS 105687..107063 /gene="radA" /locus_tag="BSU_00870" /old_locus_tag="BSU00870" /EC_number="2.1.1.63" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 10931349, 11810266, 15317759, 25616256; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA repair protein; 6-O-methylguanine-DNA methyltransferase" /protein_id="NP_387968.1" /db_xref="EnsemblGenomes-Gn:BSU00870" /db_xref="EnsemblGenomes-Tr:CAB11863" /db_xref="GOA:P37572" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004504" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR020588" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10149" /db_xref="UniProtKB/Swiss-Prot:P37572" /translation="MAKTKSKFICQSCGYESPKWMGKCPGCGAWNTMVEEMIKKAPAN RRAAFSHSVQTVQKPSPITSIETSEEPRVKTQLGEFNRVLGGGVVKGSLVLIGGDPGI GKSTLLLQVSAQLSGSSNSVLYISGEESVKQTKLRADRLGINNPSLHVLSETDMEYIS SAIQEMNPSFVVVDSIQTVYQSDITSAPGSVSQVRECTAELMKIAKTKGIPIFIVGHV TKEGSIAGPRLLEHMVDTVLYFEGERHHTFRILRAVKNRFGSTNEMGIFEMREEGLTE VLNPSEIFLEERSAGSAGSSITASMEGTRPILVEIQALISPTSFGNPRRMATGIDHNR VSLLMAVLEKRVGLLLQNQDAYLKVAGGVKLDEPAIDLAIVISIASSFRDTPPNPADC FIGEVGLTGEVRRVSRIEQRVKEAAKLGFKRMIIPAANLDGWTKPKGIEVIGVANVAE ALRTSLGG*" /label="radA CDS" gene 105687..107063 /gene="radA" /locus_tag="BSU_00870" /old_locus_tag="BSU00870" /label="radA gene" promotor_-35 106142..106151 /Source="Nicolas_upshift_promotors" /id="U83" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1648 /SigmaFactorBS="ctcggcattaataatccgtcactgcatgttttatcTGAAACC GATatggagtatattTCGTCTGCTATACAAGagatgaatccatcgtttgtcgttgttg a" /listShort="disA, S45, yacL, ispD, ispF, gltX, S46, cysE, cysS, mrnC, rlmB, yacP" /listLong="sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-35" promotor_-10 106164..106179 /Source="Nicolas_upshift_promotors" /id="U83" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1648 /SigmaFactorBS="ctcggcattaataatccgtcactgcatgttttatcTGAAACC GATatggagtatattTCGTCTGCTATACAAGagatgaatccatcgtttgtcgttgttg a" /listShort="disA, S45, yacL, ispD, ispF, gltX, S46, cysE, cysS, mrnC, rlmB, yacP" /listLong="sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-10" upshifts 106167 /Source="Nicolas_upshifts" /id="U83" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1648 /SigmaFactorBS="ctcggcattaataatccgtcactgcatgttttatcTGAAACC GATatggagtatattTCGTCTGCTATACAAGagatgaatccatcgtttgtcgttgttg a" /listShort="disA, S45, yacL, ispD, ispF, gltX, S46, cysE, cysS, mrnC, rlmB, yacP" /listLong="sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="upshifts" CDS 107067..108149 /gene="disA" /locus_tag="BSU_00880" /old_locus_tag="BSU00880" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16713562, 21566650, 24939848, 25616256, 27074767, 27150552, 28511132, 28961460" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16713562, 21566650, 24939848, 25616256, 27074767, 27150552, 28511132, 28961460; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="diadenylate cyclase; DNA integrity scanning protein; cell cycle checkpoint DNA scanning protein" /protein_id="NP_387969.1" /db_xref="EnsemblGenomes-Gn:BSU00880" /db_xref="EnsemblGenomes-Tr:CAB11864" /db_xref="GOA:P37573" /db_xref="InterPro:IPR003390" /db_xref="InterPro:IPR010994" /db_xref="InterPro:IPR018906" /db_xref="InterPro:IPR023763" /db_xref="InterPro:IPR036888" /db_xref="SubtiList:BG10150" /db_xref="UniProtKB/Swiss-Prot:P37573" /translation="MEKEKKGAKHELDLSSILQFVAPGTPLRAGMENVLRANTGGLIV VGYNDKVKEVVDGGFHINTAFSPAHLYELAKMDGAIILSDSGQKILYANTQLMPDATI SSSETGMRHRTAERVAKQTGCLVIAISERRNVITLYQENMKYTLKDIGFILTKANQAI QTLEKYKTILDKTINALNALEFEELVTFSDVLSVMHRYEMVLRIKNEINMYIKELGTE GHLIKLQVIELITDMEEEAALFIKDYVKEKIKDPFVLLKELQDMSSYDLLDDSIVYKL LGYPASTNLDDYVLPRGYRLLNKIPRLPMPIVENVVEAFGVLPRIIEASAEELDEVEG IGEVRAQKIKKGLKRLQEKHYLDRQL*" /label="disA CDS" gene 107067..108149 /gene="disA" /locus_tag="BSU_00880" /old_locus_tag="BSU00880" /label="disA gene" S_feature 108150..108264 /Source="Nicolas_S_feature" /locus_tag="new_108559_108673" /HighExp="Etha, Salt, Heat, dia15, Diami, M9-stat, B60, T-0.40H, T-1.10H, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY, SigA, SigB" /TUshortPSig="1, 1, 1" /TUlongSig="SigA" /TUlongPSig="0.947" /label="S45" CDS 108265..109365 /gene="yacL" /locus_tag="BSU_00890" /old_locus_tag="BSU00890" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 26999498; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein possibly involved in RNA binding" /protein_id="NP_387970.1" /db_xref="EnsemblGenomes-Gn:BSU00890" /db_xref="EnsemblGenomes-Tr:CAB11865" /db_xref="GOA:Q06754" /db_xref="InterPro:IPR002716" /db_xref="InterPro:IPR002792" /db_xref="InterPro:IPR029060" /db_xref="SubtiList:BG10151" /db_xref="UniProtKB/Swiss-Prot:Q06754" /translation="MLKRIVQAFFIIFGGVVGIFLIPELFVLLNIQDIPLITNAYTSA AIGAIIFFLISIWGTEYVVNWVKWIEDSLLKAPVPDLLFGSLGLVFGLIIAYLIVNVI PLDNIPYRIFSTIIPVFLAFFLGYLGFQVGFKKKDELISLFSISARMQKKKGTADEEH EVQDKKLKILDTSVIIDGRIADICQTGFLEGVIVIPQFVLEELQHIADSSDVLKRNRG RRGLDILNRIQKELDIEVEIYEGDFEDIQEVDSKLVKLAKLTSGVVVTNDFNLNKVCE LQKVAVLNINDLANAVKPVVLPGEEMNVQVIKDGKEHNQGVAYLDDGTMIVVEEGRNY IGKHIDVLVTSVLQTAAGRMIFAKPKLLEKAL*" /label="yacL CDS" gene 108265..109365 /gene="yacL" /locus_tag="BSU_00890" /old_locus_tag="BSU00890" /label="yacL gene" downshifts complement(109187) /Source="Nicolas_upshifts" /id="D39" /incds=1 /nref=1 /ntot=103 /MaxReadThrough="0.39171" /MaxDrop="2.87304" /score="-9.71423487" /energy="-11.8" /TU="NA" /idTUdmin="U82" /TUdmin="-8228" /isTUend="FALSE" /label="downshifts" CDS 109380..110078 /gene="ispD" /locus_tag="BSU_00900" /old_locus_tag="BSU00900" /EC_number="2.7.7.60" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15044829, 15379557, 16533036, 17081012, 17458547, 23840410, 27821871" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15044829, 15379557, 16533036, 17081012, 17458547, 23840410, 27821871; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase, nonmevalonate isoprenoid pathway" /protein_id="NP_387971.1" /db_xref="EnsemblGenomes-Gn:BSU00900" /db_xref="EnsemblGenomes-Tr:CAB11866" /db_xref="GOA:Q06755" /db_xref="InterPro:IPR001228" /db_xref="InterPro:IPR018294" /db_xref="InterPro:IPR029044" /db_xref="InterPro:IPR034683" /db_xref="PDB:5DDT" /db_xref="PDB:5DDV" /db_xref="PDB:5HS2" /db_xref="SubtiList:BG10152" /db_xref="UniProtKB/Swiss-Prot:Q06755" /translation="MSYDVVIPAAGQGKRMKAGRNKLFIELKGDPVIIHTLRVFDSHR QCDKIILVINEQEREHFQQLLSDYPFQTSIELVAGGDERQHSVYKGLKAVKQEKIVLV HDGARPFIKHEQIDELIAEAEQTGAAILAVPVKDTIKRVQDLQVSETIERSSLWAVQT PQAFRLSLLMKAHAEAERKGFLGTDDASLVEQMEGGSVRVVEGSYTNIKLTTPDDLTS AEAIMESESGNKHV*" /label="ispD CDS" gene 109380..110078 /gene="ispD" /locus_tag="BSU_00900" /old_locus_tag="BSU00900" /label="ispD gene" CDS 110071..110547 /gene="ispF" /locus_tag="BSU_00910" /old_locus_tag="BSU00910" /EC_number="4.6.1.12" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9622350, 11997478, 12270818, 12682299, 17458547, 23840410" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9622350, 11997478, 12270818, 12682299, 17458547, 23840410; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase" /protein_id="NP_387972.1" /db_xref="EnsemblGenomes-Gn:BSU00910" /db_xref="EnsemblGenomes-Tr:CAB11867" /db_xref="GOA:Q06756" /db_xref="InterPro:IPR003526" /db_xref="InterPro:IPR020555" /db_xref="InterPro:IPR036571" /db_xref="PDB:5IWX" /db_xref="PDB:5IWY" /db_xref="SubtiList:BG10153" /db_xref="UniProtKB/Swiss-Prot:Q06756" /translation="MFRIGQGFDVHQLVEGRPLIIGGIEIPYEKGLLGHSDADVLLHT VADACLGAVGEGDIGKHFPDTDPEFKDADSFKLLQHVWGIVKQKGYVLGNIDCTIIAQ KPKMLPYIEDMRKRIAEGLEADVSQVNVKATTTEKLGFTGRAEGIAAQATVLIQKG*" /label="ispF CDS" gene 110071..110547 /gene="ispF" /locus_tag="BSU_00910" /old_locus_tag="BSU00910" /label="ispF gene" promotor_-35 110551..110558 /Source="Nicolas_upshift_promotors" /id="U84" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.606393606393606" /psig="0.999000999001" /xcortree=2679 /SigmaFactorBS="cagtactgatacaaaaaggctaacttGTTTTGATgccgggtc tatttGGTGGTAGAATAGATTCATAcatttttgcctgaggccatacatgacatgaaag g" /listShort="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG" /listLong="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-35" promotor_-10 110572..110591 /Source="Nicolas_upshift_promotors" /id="U84" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.606393606393606" /psig="0.999000999001" /xcortree=2679 /SigmaFactorBS="cagtactgatacaaaaaggctaacttGTTTTGATgccgggtc tatttGGTGGTAGAATAGATTCATAcatttttgcctgaggccatacatgacatgaaag g" /listShort="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG" /listLong="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-10" upshifts 110585 /Source="Nicolas_upshifts" /id="U84" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.606393606393606" /psig="0.999000999001" /xcortree=2679 /SigmaFactorBS="cagtactgatacaaaaaggctaacttGTTTTGATgccgggtc tatttGGTGGTAGAATAGATTCATAcatttttgcctgaggccatacatgacatgaaag g" /listShort="gltX, S46, cysE, cysS, mrnC, rlmB, yacP, sigH, S47, rpmGB, secE, S48, nusG" /listLong="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="upshifts" CDS 110638..112089 /gene="gltX" /locus_tag="BSU_00920" /old_locus_tag="BSU00920" /EC_number="6.1.1.24" /EC_number="6.1.1.17" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2120226, 3079749, 9342321, 10024179, 10546897, 12682299, 14741355" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2120226, 3079749, 9342321, 10024179, 10546897, 12682299, 14741355; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamyl-tRNA synthetase" /protein_id="NP_387973.1" /db_xref="EnsemblGenomes-Gn:BSU00920" /db_xref="EnsemblGenomes-Tr:CAB11868" /db_xref="GOA:P22250" /db_xref="InterPro:IPR000924" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR004527" /db_xref="InterPro:IPR008925" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR020058" /db_xref="InterPro:IPR020061" /db_xref="InterPro:IPR020751" /db_xref="InterPro:IPR020752" /db_xref="InterPro:IPR033910" /db_xref="SubtiList:BG10154" /db_xref="UniProtKB/Swiss-Prot:P22250" /translation="MGNEVRVRYAPSPTGHLHIGNARTALFNYLFARNQGGKFIIRVE DTDKKRNIEGGEQSQLNYLKWLGIDWDESVDVGGEYGPYRQSERNDIYKVYYEELLEK GLAYKCYCTEEELEKEREEQIARGEMPRYSGKHRDLTQEEQEKFIAEGRKPSIRFRVP EGKVIAFNDIVKGEISFESDGIGDFVIVKKDGTPTYNFAVAIDDYLMKMTHVLRGEDH ISNTPKQIMIYQAFGWDIPQFGHMTLIVNESRKKLSKRDESIIQFIEQYKELGYLPEA LFNFIGLLGWSPVGEEELFTKEQFIEIFDVNRLSKSPALFDMHKLKWVNNQYVKKLDL DQVVELTLPHLQKAGKVGTELSAEEQEWVRKLISLYHEQLSYGAEIVELTDLFFTDEI EYNQEAKAVLEEEQVPEVLSTFAAKLEELEEFTPDNIKASIKAVQKETGHKGKKLFMP IRVAVTGQTHGPELPQSIELIGKETAIQRLKNI*" /label="gltX CDS" gene 110638..112089 /gene="gltX" /locus_tag="BSU_00920" /old_locus_tag="BSU00920" /label="gltX gene" promotor_-35 111567..111576 /Source="Nicolas_upshift_promotors" /id="U85" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1307 /SigmaFactorBS="agcagtttattgaaatttttgatgtaaatcgtttatcTAAAT CACCAgctttgtttgataTGCATAAGCTAAAATGGGTTaacaaccaatatgtgaagaa g" /listShort="S46, cysE, cysS, mrnC, rlmB, yacP" /listLong="sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA" /label="promotor_-35" promotor_-10 111590..111609 /Source="Nicolas_upshift_promotors" /id="U85" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1307 /SigmaFactorBS="agcagtttattgaaatttttgatgtaaatcgtttatcTAAAT CACCAgctttgtttgataTGCATAAGCTAAAATGGGTTaacaaccaatatgtgaagaa g" /listShort="S46, cysE, cysS, mrnC, rlmB, yacP" /listLong="sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA" /label="promotor_-10" upshifts 111590 /Source="Nicolas_upshifts" /id="U85" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1307 /SigmaFactorBS="agcagtttattgaaatttttgatgtaaatcgtttatcTAAAT CACCAgctttgtttgataTGCATAAGCTAAAATGGGTTaacaaccaatatgtgaagaa g" /listShort="S46, cysE, cysS, mrnC, rlmB, yacP" /listLong="sigH, S47, rpmGB, secE, S48, nusG, S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA" /label="upshifts" S_feature 112090..112390 /Source="Nicolas_S_feature" /locus_tag="new_112499_112799" /HighExp="S6, S8, S7, Diami, C90, LBGexp, G135, H2O2, dia5, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.17844199999999999" /TUshortSig="SigK, SigA, SigWXY" /TUshortPSig="1, 0.999, 1" /TUlongSig="SigA, SigB, SigA" /TUlongPSig="1, 1, 0.947" /label="S46" CDS 112391..113044 /gene="cysE" /locus_tag="BSU_00930" /old_locus_tag="BSU00930" /EC_number="2.3.1.30" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:7510287, 10737181, 10939241, 17056751, 18974048, 25731080" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7510287, 10737181, 10939241, 17056751, 18974048, 25731080; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="serine O-acetyltransferase" /protein_id="NP_387974.1" /db_xref="EnsemblGenomes-Gn:BSU00930" /db_xref="EnsemblGenomes-Tr:CAB11869" /db_xref="GOA:Q06750" /db_xref="InterPro:IPR001451" /db_xref="InterPro:IPR005881" /db_xref="InterPro:IPR010493" /db_xref="InterPro:IPR011004" /db_xref="InterPro:IPR018357" /db_xref="SubtiList:BG10155" /db_xref="UniProtKB/Swiss-Prot:Q06750" /translation="MFFRMLKEDIDTVFDQDPAARSYFEVILTYSGLHAIWAHRIAHA LYKRKFYFLARLISQVSRFFTGIEIHPGATIGRRFFIDHGMGVVIGETCEIGNNVTVF QGVTLGGTGKEKGKRHPTIKDDALIATGAKVLGSITVGEGSKIGAGSVVLHDVPDFST VVGIPGRVVVQNGKKVRRDLNHQDLPDPVADRFKSLEQQILELKAELEDRKERINQK* " /label="cysE CDS" gene 112391..113044 /gene="cysE" /locus_tag="BSU_00930" /old_locus_tag="BSU00930" /label="cysE gene" CDS 113041..114441 /gene="cysS" /locus_tag="BSU_00940" /old_locus_tag="BSU00940" /EC_number="6.1.1.16" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10024179, 10546897, 10931887, 12682299, 29079736" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10024179, 10546897, 10931887, 12682299, 29079736; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dual cysteinyl-tRNA synthetase; cysteine persulfide synthase" /protein_id="NP_387975.1" /db_xref="EnsemblGenomes-Gn:BSU00940" /db_xref="EnsemblGenomes-Tr:CAB11870" /db_xref="GOA:Q06752" /db_xref="InterPro:IPR009080" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR015273" /db_xref="InterPro:IPR015803" /db_xref="InterPro:IPR024909" /db_xref="InterPro:IPR032678" /db_xref="SubtiList:BG10156" /db_xref="UniProtKB/Swiss-Prot:Q06752" /translation="MTITLYNTLTRQKETFVPLEEGKVKMYVCGPTVYNYIHIGNARP AIVYDTVRNYLEYKGYDVQYVSNFTDVDDKLIKAANELGEDVPTISERFIKAYFEDVG ALGCRKADLHPRVMENMDAIIEFVDQLVKKGYAYESEGDVYFKTRAFEGYGKLSQQSI DELRSGARIRVGEKKEDALDFALWKAAKEGEISWDSPWGKGRPGWHIECSAMVKKYLG DQIDIHAGGQDLTFPHHENEIAQSEALTGKTFAKYWLHNGYINIDNEKMSKSLGNFVL VHDIIKQHDPQLLRFFMLSVHYRHPINYSEELLENTKSAFSRLKTAYSNLQHRLNSST NLTEDDDQWLEKVEEHRKAFEEEMDDDFNTANAISVLFDLAKHANYYLQKDHTADHVI TAFIEMFDRIVSVLGFSLGEQELLDQEIEDLIEKRNEARRNRDFALSDQIRDQLKSMN IILEDTAQGTRWKRGE*" /label="cysS CDS" gene 113041..114441 /gene="cysS" /locus_tag="BSU_00940" /old_locus_tag="BSU00940" /label="cysS gene" CDS 114445..114876 /gene="mrnC" /locus_tag="BSU_00950" /old_locus_tag="BSU00950" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16014871, 25634891, 27924926" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16014871, 25634891, 27924926; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease for 23S RNA maturation, mini-RNase III" /protein_id="NP_387976.1" /db_xref="EnsemblGenomes-Gn:BSU00950" /db_xref="EnsemblGenomes-Tr:CAB11871" /db_xref="GOA:O31418" /db_xref="InterPro:IPR000999" /db_xref="InterPro:IPR008226" /db_xref="InterPro:IPR036389" /db_xref="PDB:4OUN" /db_xref="SubtiList:BG12702" /db_xref="UniProtKB/Swiss-Prot:O31418" /translation="MLEFDTIKDSKQLNGLALAYIGDAIFEVYVRHHLLKQGFTKPND LHKKSSRIVSAKSQAEILFFLQNQSFFTEEEEAVLKRGRNAKSGTTPKNTDVQTYRYS TAFEALLGYLFLEKKEERLSQLVAEAIQFGTSGRKTNESAT*" /label="mrnC CDS" gene 114445..114876 /gene="mrnC" /locus_tag="BSU_00950" /old_locus_tag="BSU00950" /label="mrnC gene" CDS 114860..115609 /gene="rlmB" /locus_tag="BSU_00960" /old_locus_tag="BSU00960" /EC_number="2.1.1.185" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11698387, 12377117, 16014871; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="23S rRNA (Gm2251)-methyltransferase" /protein_id="NP_387977.1" /db_xref="EnsemblGenomes-Gn:BSU00960" /db_xref="EnsemblGenomes-Tr:CAB11872" /db_xref="GOA:Q06753" /db_xref="InterPro:IPR001537" /db_xref="InterPro:IPR004441" /db_xref="InterPro:IPR013123" /db_xref="InterPro:IPR029026" /db_xref="InterPro:IPR029028" /db_xref="InterPro:IPR029064" /db_xref="SubtiList:BG10157" /db_xref="UniProtKB/Swiss-Prot:Q06753" /translation="MSQQHDYVIGKNAVIETLKSDRKLYKLWMAENTVKGQAQQVIEL AKKQGITIQYVPRKKLDQMVTGQHQGVVAQVAAYEYAELDDLYKAAEEKNEQPFFLIL DELEDPHNLGSIMRTADAVGAHGIVIPKRRAVGLTTTVAKASTGAIEHIPVARVTNLA RTLEEMKERGIWVVGTDASAREDFRNMDGNMPLALVIGSEGKGMGRLVKEKCDFLIKL PMAGKVTSLNASVAAGLLMYEVYRKRNPVGE*" /label="rlmB CDS" gene 114860..115609 /gene="rlmB" /locus_tag="BSU_00960" /old_locus_tag="BSU00960" /label="rlmB gene" CDS 115616..116128 /gene="raeA" /locus_tag="BSU_00970" /old_locus_tag="BSU00970" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:17114934, 23355615, 28363943" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17114934, 23355615, 28363943; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribosome-dependent mRNA endonuclease" /protein_id="NP_387978.1" /db_xref="EnsemblGenomes-Gn:BSU00970" /db_xref="EnsemblGenomes-Tr:CAB11873" /db_xref="InterPro:IPR010298" /db_xref="PDB:5MQ8" /db_xref="PDB:5MQ9" /db_xref="SubtiList:BG10158" /db_xref="UniProtKB/Swiss-Prot:P37574" /translation="MDILLVDGYNMIGAWPQLKDLKANSFEEARDVLIQKMAEYQSYT GNRVIVVFDAHLVKGLEKKQTNHRVEVIFTKENETADERIEKLAQALNNIATQIHVAT SDYTEQWAIFGQGALRKSARELLREVETIERRIERRVRKITSEKPAGKIALSEEVLKT FEKWRRGDLD*" /label="raeA CDS" gene 115616..116128 /gene="raeA" /locus_tag="BSU_00970" /old_locus_tag="BSU00970" /label="raeA gene" promotor_-35 116127..116134 /Source="Nicolas_upshift_promotors" /id="U86" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.71028971028971" /psig=1 /xcortree=3212 /SigmaFactorBS="aaacgtttgaaaagtggaggcggggagacttagattAAGTTG ACgcttttttgcccaaTACTGTATAATATTTCTATCtacgtgcgccggggggatcgga g" /listShort="sigH, S47, rpmGB, secE, S48, nusG" /listLong="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-35" promotor_-10 116149..116168 /Source="Nicolas_upshift_promotors" /id="U86" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.71028971028971" /psig=1 /xcortree=3212 /SigmaFactorBS="aaacgtttgaaaagtggaggcggggagacttagattAAGTTG ACgcttttttgcccaaTACTGTATAATATTTCTATCtacgtgcgccggggggatcgga g" /listShort="sigH, S47, rpmGB, secE, S48, nusG" /listLong="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-10" upshifts 116151 /Source="Nicolas_upshifts" /id="U86" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.71028971028971" /psig=1 /xcortree=3212 /SigmaFactorBS="aaacgtttgaaaagtggaggcggggagacttagattAAGTTG ACgcttttttgcccaaTACTGTATAATATTTCTATCtacgtgcgccggggggatcgga g" /listShort="sigH, S47, rpmGB, secE, S48, nusG" /listLong="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC, S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="upshifts" CDS 116191..116847 /gene="sigH" /locus_tag="BSU_00980" /old_locus_tag="BSU00980" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12169614, 16339734, 25288929, 26712348" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12169614, 16339734, 25288929, 26712348; Product type f: factor" /codon_start=1 /transl_table=11 /product="RNA polymerase sigma-30 factor (sigma(H))" /protein_id="NP_387979.1" /db_xref="EnsemblGenomes-Gn:BSU00980" /db_xref="EnsemblGenomes-Tr:CAB11874" /db_xref="GOA:P17869" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR000943" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013249" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014218" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR016371" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10159" /db_xref="UniProtKB/Swiss-Prot:P17869" /translation="MNLQNNKGKFNKEQFCQLEDEQVIEKVHVGDSDALDYLITKYRN FVRAKARSYFLIGADREDIVQEGMIGLYKSIRDFKEDKLTSFKAFAELCITRQIITAI KTATRQKHIPLNSYASLDKPIFDEESDRTLLDVISGAKTLNPEEMIINQEEFDDIEMK MGELLSDLERKVLVLYLDGRSYQEISDELNRHVKSIDNALQRVKRKLEKYLEIREISL *" /label="sigH CDS" gene 116191..116847 /gene="sigH" /locus_tag="BSU_00980" /old_locus_tag="BSU00980" /label="sigH gene" downshifts complement(116645) /Source="Nicolas_upshifts" /id="D40" /incds=1 /nref=1 /ntot=107 /MaxReadThrough="2.38622" /MaxDrop="2.50464" /score="-2.56993398" /energy="-10.3" /TU="NA" /idTUdmin="U87" /TUdmin=836 /isTUend="FALSE" /label="downshifts" S_feature 116848..116939 /Source="Nicolas_S_feature" /locus_tag="new_117257_117348" /HighExp="T4.0H, T3.30H, T3.0H, T2.30H, S1, S2, T5.0H, HiOs, T2.0H, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="SigK, SigWXY, SigA, SigB, SigA" /TUlongPSig="1, 1, 1, 1, 0.947" /label="S47" CDS 116940..117089 /gene="rpmGB" /locus_tag="BSU_00990" /old_locus_tag="BSU00990" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14586115, 19648245, 23002217, 27561249" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14586115, 19648245, 23002217, 27561249; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosomal protein L33" /protein_id="NP_387980.1" /db_xref="EnsemblGenomes-Gn:BSU00990" /db_xref="EnsemblGenomes-Tr:CAB11875" /db_xref="GOA:Q06798" /db_xref="InterPro:IPR001705" /db_xref="InterPro:IPR011332" /db_xref="InterPro:IPR018264" /db_xref="SubtiList:BG10160" /db_xref="UniProtKB/Swiss-Prot:Q06798" /translation="MRKKITLACKTCGNRNYTTMKSSASAAERLEVKKYCSTCNSHTA HLETK*" /label="rpmGB CDS" gene 116940..117089 /gene="rpmGB" /locus_tag="BSU_00990" /old_locus_tag="BSU00990" /label="rpmGB gene" CDS 117123..117302 /gene="secE" /locus_tag="BSU_01000" /old_locus_tag="BSU01000" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11976315, 12682299, 16242710, 22304380, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11976315, 12682299, 16242710, 22304380, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="preprotein translocase subunit" /protein_id="NP_387981.1" /db_xref="EnsemblGenomes-Gn:BSU01000" /db_xref="EnsemblGenomes-Tr:CAB11876" /db_xref="GOA:Q06799" /db_xref="InterPro:IPR001901" /db_xref="InterPro:IPR005807" /db_xref="InterPro:IPR022943" /db_xref="SubtiList:BG10161" /db_xref="UniProtKB/Swiss-Prot:Q06799" /translation="MRIMKFFKDVGKEMKKVSWPKGKELTRYTITVISTVIFFVIFFA LLDTGISQLIRLIVE*" /label="secE CDS" gene 117123..117302 /gene="secE" /locus_tag="BSU_01000" /old_locus_tag="BSU01000" /label="secE gene" S_feature 117303..117480 /Source="Nicolas_S_feature" /locus_tag="new_117712_117889" /HighExp="Cold, G180, G150, H2O2, LoTm, Oxctl, G135, Paraq, LBGexp, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="SigK, SigWXY, SigA, SigB, SigA" /TUlongPSig="1, 1, 1, 1, 0.947" /label="S48" downshifts complement(117474) /Source="Nicolas_upshifts" /id="D41" /incds=0 /nref=37 /ntot=175 /MaxReadThrough="1.57397" /MaxDrop="4.03552" /score="-2.56993398" /energy="-10.3" /TU="NA" /idTUdmin="U87" /TUdmin=7 /isTUend="TRUE" /label="downshifts" CDS 117481..118014 /gene="nusG" /locus_tag="BSU_01010" /old_locus_tag="BSU01010" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11101662, 16014871, 16707701, 18852477, 26742846, 28507243" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11101662, 16014871, 16707701, 18852477, 26742846, 28507243; Product type f : factor" /codon_start=1 /transl_table=11 /product="RNA polymerase elongation pause factor" /protein_id="NP_387982.1" /db_xref="EnsemblGenomes-Gn:BSU01010" /db_xref="EnsemblGenomes-Tr:CAB11877" /db_xref="GOA:Q06795" /db_xref="InterPro:IPR001062" /db_xref="InterPro:IPR005824" /db_xref="InterPro:IPR006645" /db_xref="InterPro:IPR008991" /db_xref="InterPro:IPR014722" /db_xref="InterPro:IPR015869" /db_xref="InterPro:IPR036735" /db_xref="SubtiList:BG10162" /db_xref="UniProtKB/Swiss-Prot:Q06795" /translation="MEKNWYVVHTYSGYENKVKANLEKRVESMGMQDKIFRVVVPEEE ETDIKNGKKKVVKKKVFPGYVLVEIVMTDDSWYVVRNTPGVTGFVGSAGSGSKPTPLL PGEAETILKRMGMDERKTDIDFELKETVKVIDGPFANFTGSIEEIDYDKSKVKVFVNM FGRETPVELEFTQIDKL*" /label="nusG CDS" gene 117481..118014 /gene="nusG" /locus_tag="BSU_01010" /old_locus_tag="BSU01010" /label="nusG gene" upshifts complement(117569) /Source="Nicolas_upshifts" /id="U87" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.98001998001998" /psig="0.002997002997003" /xcortree=29 /SigmaFactorBS="tttttgatatccgtttcttcttcttcgggtacgACTACAcgg aaaattttatcCTGCAtccccattgattcaacacgcttttccaagttggcttttactt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(117572..117576) /Source="Nicolas_upshift_promotors" /id="U87" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.98001998001998" /psig="0.002997002997003" /xcortree=29 /SigmaFactorBS="tttttgatatccgtttcttcttcttcgggtacgACTACAcgg aaaattttatcCTGCAtccccattgattcaacacgcttttccaagttggcttttactt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(117591..117596) /Source="Nicolas_upshift_promotors" /id="U87" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.98001998001998" /psig="0.002997002997003" /xcortree=29 /SigmaFactorBS="tttttgatatccgtttcttcttcttcgggtacgACTACAcgg aaaattttatcCTGCAtccccattgattcaacacgcttttccaagttggcttttactt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 118025..118032 /Source="Nicolas_upshift_promotors" /id="U88" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.787212787212787" /psig=1 /xcortree=2652 /SigmaFactorBS="agctggaatttacccaaatcgataaattgtaatgtgaaaaaa CTTGAAATtgctatatataaaTGATAATATAGCAAAGGTACgtcttggacttatccaa g" /listShort="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-35" S_feature 118043..118181 /Source="Nicolas_S_feature" /locus_tag="new_118452_118590" /HighExp="T-1.40H, ferm, T-3.40H, T-5.40H, BI, B36, LoTm, SMM, T-2.40H, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigK, SigA, SigWXY, SigA, SigB, SigA" /TUlongPSig="1, 1, 0.999, 1, 1, 1, 0.947" /label="S49" upshifts 118043 /Source="Nicolas_upshifts" /id="U88" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.787212787212787" /psig=1 /xcortree=2652 /SigmaFactorBS="agctggaatttacccaaatcgataaattgtaatgtgaaaaaa CTTGAAATtgctatatataaaTGATAATATAGCAAAGGTACgtcttggacttatccaa g" /listShort="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="upshifts" promotor_-10 118046..118065 /Source="Nicolas_upshift_promotors" /id="U88" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.787212787212787" /psig=1 /xcortree=2652 /SigmaFactorBS="agctggaatttacccaaatcgataaattgtaatgtgaaaaaa CTTGAAATtgctatatataaaTGATAATATAGCAAAGGTACgtcttggacttatccaa g" /listShort="S49, rplK, S50, rplA, NA, rplJ, rplL, ybxB, S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-10" CDS 118182..118607 /gene="rplK" /locus_tag="BSU_01020" /old_locus_tag="BSU01020" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11244072, 19653700, 20441189" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11244072, 19653700, 20441189; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L11 (BL11)" /protein_id="NP_387983.2" /db_xref="EnsemblGenomes-Gn:BSU01020" /db_xref="EnsemblGenomes-Tr:CAB11878" /db_xref="GOA:Q06796" /db_xref="InterPro:IPR000911" /db_xref="InterPro:IPR006519" /db_xref="InterPro:IPR020783" /db_xref="InterPro:IPR020784" /db_xref="InterPro:IPR020785" /db_xref="InterPro:IPR036769" /db_xref="InterPro:IPR036796" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="SubtiList:BG10163" /db_xref="UniProtKB/Swiss-Prot:Q06796" /translation="MAKKVVKVVKLQIPAGKANPAPPVGPALGQAGVNIMGFCKEFNA RTADQAGLIIPVEISVYEDRSFTFITKTPPAAVLLKKAAGIESGSGEPNRNKVATVKR DKVREIAETKMPDLNAADVEAAMRMVEGTARSMGIVIED*" /label="rplK CDS" gene 118182..118607 /gene="rplK" /locus_tag="BSU_01020" /old_locus_tag="BSU01020" /label="rplK gene" S_feature 118608..118701 /Source="Nicolas_S_feature" /locus_tag="new_119017_119110" /HighExp="HPh, LPh, Lbexp, G180, LBGexp, G150, Heat, Cold, Fru, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigK, SigA, SigWXY, SigA, SigB, SigA" /TUlongPSig="1, 1, 0.999, 1, 1, 1, 0.947" /label="S50" CDS 118702..119400 /gene="rplA" /locus_tag="BSU_01030" /old_locus_tag="BSU01030" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 16352840, 17981968, 22720735; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L1 (BL1)" /protein_id="NP_387984.2" /db_xref="EnsemblGenomes-Gn:BSU01030" /db_xref="EnsemblGenomes-Tr:CAB11879" /db_xref="GOA:Q06797" /db_xref="InterPro:IPR002143" /db_xref="InterPro:IPR005878" /db_xref="InterPro:IPR016095" /db_xref="InterPro:IPR023673" /db_xref="InterPro:IPR023674" /db_xref="InterPro:IPR028364" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="SubtiList:BG10164" /db_xref="UniProtKB/Swiss-Prot:Q06797" /translation="MAKKGKKYVEAAKLVDRSKAYDVSEAVALVKKTNTAKFDATVEV AFRLGVDPRKNDQQIRGAVVLPNGTGKTQRVLVFAKGEKAKEAEAAGADFVGDTDYIN KIQQGWFDFDVIVATPDMMGEVGKIGRVLGPKGLMPNPKTGTVTFEVEKAIGEIKAGK VEYRVDKAGNIHVPIGKVSFEDEKLVENFTTMYDTILKAKPAAAKGVYVKNVAVTSTM GPGVKVDSSTFNVK*" /label="rplA CDS" gene 118702..119400 /gene="rplA" /locus_tag="BSU_01030" /old_locus_tag="BSU01030" /label="rplA gene" downshifts complement(119374) /Source="Nicolas_upshifts" /id="D42" /incds=0 /nref=3 /ntot=95 /MaxReadThrough="3.54108" /MaxDrop="3.36566" /score="-2.56993398" /energy="-10.3" /TU="NA" /idTUdmin="U89" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_RNA 119446..119586 /gene="ldlJ" /locus_tag="BSU_misc_RNA_3" /product="L10_leader" /experiment="publication(s) with functional evidences, PMID:26101249" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 26101249; Product type n: RNA" /label="ldlJ RNA" gene 119446..119586 /gene="ldlJ" /locus_tag="BSU_misc_RNA_3" /label="ldlJ gene" upshifts complement(119462) /Source="Nicolas_upshifts" /id="U89" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.603396603396603" /psig="0.248751248751249" /xcortree=60 /SigmaFactorBS="gctgtgataatatacacctcggtaggataattaagcggttag gcccctactgtCTACGgtataaatgatattctattttacaacattttgaataatatca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(119465..119469) /Source="Nicolas_upshift_promotors" /id="U89" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.603396603396603" /psig="0.248751248751249" /xcortree=60 /SigmaFactorBS="gctgtgataatatacacctcggtaggataattaagcggttag gcccctactgtCTACGgtataaatgatattctattttacaacattttgaataatatca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" downshifts 119518 /Source="Nicolas_upshifts" /id="D43" /incds=1 /nref=1 /ntot=19 /MaxReadThrough="9.14839" /MaxDrop="2.9211" /score="20.0562348" /energy="-13.2" /TU="U88" /idTUdmin="U84" /TUdmin=1497 /isTUend="FALSE" /label="downshifts" CDS 119652..120152 /gene="rplJ" /locus_tag="BSU_01040" /old_locus_tag="BSU01040" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9810686, 11341315, 12682299, 18247578, 26101249, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9810686, 11341315, 12682299, 18247578, 26101249, 22720735; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L10 (BL5)" /protein_id="NP_387985.2" /db_xref="EnsemblGenomes-Gn:BSU01040" /db_xref="EnsemblGenomes-Tr:CAB11880" /db_xref="GOA:P42923" /db_xref="InterPro:IPR001790" /db_xref="InterPro:IPR002363" /db_xref="InterPro:IPR022973" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11220" /db_xref="UniProtKB/Swiss-Prot:P42923" /translation="MSSAIETKKVVVEEIASKLKESKSTIIVDYRGLNVSEVTELRKQ LREANVEFKVYKNTMTRRAVEQAELNGLNDFLTGPNAIAFSTEDVVAPAKVLNDFAKN HEALEIKAGVIEGKVSTVEEVKALAELPSREGLLSMLLSVLQAPVRNLALAAKAVAEQ KEEQGA*" /label="rplJ CDS" gene 119652..120152 /gene="rplJ" /locus_tag="BSU_01040" /old_locus_tag="BSU01040" /label="rplJ gene" CDS 120198..120569 /gene="rplL" /locus_tag="BSU_01050" /old_locus_tag="BSU01050" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 6771249, 8755892, 26101249" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 6771249, 8755892, 26101249; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L12 (BL9)" /protein_id="NP_387986.1" /db_xref="EnsemblGenomes-Gn:BSU01050" /db_xref="EnsemblGenomes-Tr:CAB11881" /db_xref="GOA:P02394" /db_xref="InterPro:IPR000206" /db_xref="InterPro:IPR008932" /db_xref="InterPro:IPR013823" /db_xref="InterPro:IPR014719" /db_xref="InterPro:IPR036235" /db_xref="SubtiList:BG10726" /db_xref="UniProtKB/Swiss-Prot:P02394" /translation="MALNIEEIIASVKEATVLELNDLVKAIEEEFGVTAAAPVAVAGG AAAGGAAEEQSEFDLILAGAGSQKIKVIKVVREITGLGLKEAKELVDNTPKPLKEGIA KEEAEELKAKLEEVGASVEVK*" /label="rplL CDS" gene 120198..120569 /gene="rplL" /locus_tag="BSU_01050" /old_locus_tag="BSU01050" /label="rplL gene" downshifts 120485 /Source="Nicolas_upshifts" /id="D44" /incds=1 /nref=5 /ntot=149 /MaxReadThrough="8.89506" /MaxDrop="4.0945" /score="20.6066659" /energy="-11.7" /TU="U88" /idTUdmin="U84" /TUdmin=2464 /isTUend="FALSE" /label="downshifts" downshifts 120558 /Source="Nicolas_upshifts" /id="D45" /incds=0 /nref=25 /ntot=157 /MaxReadThrough="7.44654" /MaxDrop="4.0033" /score="20.6066659" /energy="-11.7" /TU="U88" /idTUdmin="U84" /TUdmin=2537 /isTUend="FALSE" /label="downshifts" CDS 120659..121264 /gene="rlmG" /locus_tag="BSU_01060" /old_locus_tag="BSU01060" /EC_number="2.1.1.174" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17010380; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="23S rRNA m2G1835 methyltransferase" /protein_id="NP_387987.1" /db_xref="EnsemblGenomes-Gn:BSU01060" /db_xref="EnsemblGenomes-Tr:CAB11882" /db_xref="GOA:P37872" /db_xref="InterPro:IPR007848" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG10727" /db_xref="UniProtKB/Swiss-Prot:P37872" /translation="MSEHYYSEKPSVKSNKQTWSFRLRNKDFTFTSDSGVFSKKEVDF GSRLLIDSFEEPEVEGGILDVGCGYGPIGLSLASDFKDRTIHMIDVNERAVELSNENA EQNGITNVKIYQSDLFSNVDSAQTFASILTNPPIRAGKKVVHAIFEKSAEHLKASGEL WIVIQKKQGAPSAIEKLEELFDEVSVVQKKKGYYIIKAKKV*" /label="rlmG CDS" gene 120659..121264 /gene="rlmG" /locus_tag="BSU_01060" /old_locus_tag="BSU01060" /label="rlmG gene" promotor_-35 121259..121263 /Source="Nicolas_upshift_promotors" /id="U90" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.586413586413586" /psig="0.997002997002997" /xcortree=2493 /SigmaFactorBS="gttcaaaaaaagaaaggctattatatcataaaagcaaaaaaa GTTTGactcggtattttaacTATGTTAATATTGTAAAATGccaatgtatatattttgc t" /listShort="S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-35" S_feature 121277..121509 /Source="Nicolas_S_feature" /locus_tag="new_121686_121918" /HighExp="G180, G150, H2O2, G135, Cold, T-5.40H, LoTm, T-3.40H, Oxctl, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 1" /TUlongSig="SigA, SigK, SigA, SigWXY, SigA, SigB, SigA" /TUlongPSig="1, 1, 0.999, 1, 1, 1, 0.947" /label="S51" upshifts 121277 /Source="Nicolas_upshifts" /id="U90" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.586413586413586" /psig="0.997002997002997" /xcortree=2493 /SigmaFactorBS="gttcaaaaaaagaaaggctattatatcataaaagcaaaaaaa GTTTGactcggtattttaacTATGTTAATATTGTAAAATGccaatgtatatattttgc t" /listShort="S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="upshifts" promotor_-10 121279..121298 /Source="Nicolas_upshift_promotors" /id="U90" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.586413586413586" /psig="0.997002997002997" /xcortree=2493 /SigmaFactorBS="gttcaaaaaaagaaaggctattatatcataaaagcaaaaaaa GTTTGactcggtattttaacTATGTTAATATTGTAAAATGccaatgtatatattttgc t" /listShort="S51, rpoB, rpoC, S52, rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-10" CDS 121510..125091 /gene="rpoB" /locus_tag="BSU_01070" /old_locus_tag="BSU01070" /EC_number="2.7.7.6" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10049799, 10744988, 12455702, 12682299, 15060052, 28163698" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10049799, 10744988, 12455702, 12682299, 15060052, 28163698; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="RNA polymerase (beta subunit)" /protein_id="NP_387988.2" /db_xref="EnsemblGenomes-Gn:BSU01070" /db_xref="EnsemblGenomes-Tr:CAB11883" /db_xref="GOA:P37870" /db_xref="InterPro:IPR007120" /db_xref="InterPro:IPR007121" /db_xref="InterPro:IPR007641" /db_xref="InterPro:IPR007642" /db_xref="InterPro:IPR007644" /db_xref="InterPro:IPR007645" /db_xref="InterPro:IPR010243" /db_xref="InterPro:IPR015712" /db_xref="InterPro:IPR019462" /db_xref="PDB:2LY7" /db_xref="SubtiList:BG10728" /db_xref="UniProtKB/Swiss-Prot:P37870" /translation="MTGQLVQYGRHRQRRSYARISEVLELPNLIEIQTSSYQWFLDEG LREMFQDISPIEDFTGNLSLEFIDYSLGEPKYPVEESKERDVTYSAPLRVKVRLINKE TGEVKDQDVFMGDFPIMTDTGTFIINGAERVIVSQLVRSPSVYFSGKVDKNGKKGFTA TVIPNRGAWLEYETDAKDVVYVRIDRTRKLPVTVLLRALGFGSDQEILDLIGENEYLR NTLDKDNTENSDKALLEIYERLRPGEPPTVENAKSLLDSRFFDPKRYDLANVGRYKIN KKLHIKNRLFNQRLAETLVDPETGEILAEKGQILDRRTLDKVLPYLENGIGFRKLYPN GGVVEDEVTLQSIKIFAPTDQEGEQVINVIGNAYIEEEIKNITPADIISSISYFFNLL HGVGDTDDIDHLGNRRLRSVGELLQNQFRIGLSRMERVVRERMSIQDTNTITPQQLIN IRPVIASIKEFFGSSQLSQFMDQTNPLAELTHKRRLSALGPGGLTRERAGMEVRDVHY SHYGRMCPIETPEGPNIGLINSLSSYAKVNRFGFIETPYRRVDPETGKVTGRIDYLTA DEEDNYVVAQANARLDDEGAFIDDSIVARFRGENTVVSRNRVDYMDVSPKQVVSAATA CIPFLENDDSNRALMGANMQRQAVPLMQPEAPFVGTGMEYVSGKDSGAAVICKHPGIV ERVEAKNVWVRRYEEVDGQKVKGNLDKYSLLKFVRSNQGTCYNQRPIVSVGDEVVKGE ILADGPSMELGELALGRNVMVGFMTWDGYNYEDAIIMSERLVKDDVYTSIHIEEYESE ARDTKLGPEEITRDIPNVGEDALRNLDDRGIIRIGAEVKDGDLLVGKVTPKGVTELTA EERLLHAIFGEKAREVRDTSLRVPHGGGGIIHDVKVFNREDGDELPPGVNQLVRVYIV QKRKISEGDKMAGRHGNKGVISKILPEEDMPYLPDGTPIDIMLNPLGVPSRMNIGQVL ELHMGMAARYLGIHIASPVFDGAREEDVWETLEEAGMSRDAKTVLYDGRTGEPFDNRV SVGIMYMIKLAHMVDDKLHARSTGPYSLVTQQPLGGKAQFGGQRFGEMEVWALEAYGA AYTLQEILTVKSDDVVGRVKTYEAIVKGDNVPEPGVPESFKVLIKELQSLGMDVKILS GDEEEIEMRDLEDEEDAKQADGLALSGDEEPEETASADVERDVVTKE*" /label="rpoB CDS" gene 121510..125091 /gene="rpoB" /locus_tag="BSU_01070" /old_locus_tag="BSU01070" /label="rpoB gene" promotor_-10 complement(123095..123114) /Source="Nicolas_upshift_promotors" /id="U91" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1252 /SigmaFactorBS="acgcggcgatatggcgtttcaATAAAGCCAAaacggtttact ttTGCATAAGATGATAGTGAGTtgatcaaaccgatgttcgggccctcaggcgtttcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(123098) /Source="Nicolas_upshifts" /id="U91" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1252 /SigmaFactorBS="acgcggcgatatggcgtttcaATAAAGCCAAaacggtttact ttTGCATAAGATGATAGTGAGTtgatcaaaccgatgttcgggccctcaggcgtttcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(123128..123137) /Source="Nicolas_upshift_promotors" /id="U91" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1252 /SigmaFactorBS="acgcggcgatatggcgtttcaATAAAGCCAAaacggtttact ttTGCATAAGATGATAGTGAGTtgatcaaaccgatgttcgggccctcaggcgtttcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(123966..123970) /Source="Nicolas_upshift_promotors" /id="U92" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96103896103896" /psig=0 /xcortree=63 /SigmaFactorBS="agatctccgtcttttacttctgccccaatacggatgattcCG CGGTCatcaagattgcgaaGCGCAtcttcaccgacgtttggaatatcgcgagtgattt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(123971) /Source="Nicolas_upshifts" /id="U92" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96103896103896" /psig=0 /xcortree=63 /SigmaFactorBS="agatctccgtcttttacttctgccccaatacggatgattcCG CGGTCatcaagattgcgaaGCGCAtcttcaccgacgtttggaatatcgcgagtgattt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(123985..123991) /Source="Nicolas_upshift_promotors" /id="U92" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96103896103896" /psig=0 /xcortree=63 /SigmaFactorBS="agatctccgtcttttacttctgccccaatacggatgattcCG CGGTCatcaagattgcgaaGCGCAtcttcaccgacgtttggaatatcgcgagtgattt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 125153..128752 /gene="rpoC" /locus_tag="BSU_01080" /old_locus_tag="BSU01080" /EC_number="2.7.7.6" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10672039, 10675340, 10910724, 11029421, 9795209, 10438769, 23070162, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10672039, 10675340, 10910724, 11029421, 9795209, 10438769, 23070162, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="RNA polymerase (beta' subunit)" /protein_id="NP_387989.2" /db_xref="EnsemblGenomes-Gn:BSU01080" /db_xref="EnsemblGenomes-Tr:CAB11884" /db_xref="GOA:P37871" /db_xref="InterPro:IPR000722" /db_xref="InterPro:IPR006592" /db_xref="InterPro:IPR007066" /db_xref="InterPro:IPR007080" /db_xref="InterPro:IPR007081" /db_xref="InterPro:IPR007083" /db_xref="InterPro:IPR012754" /db_xref="SubtiList:BG10729" /db_xref="UniProtKB/Swiss-Prot:P37871" /translation="MLDVNNFEYMNIGLASPDKIRSWSFGEVKKPETINYRTLKPEKD GLFCERIFGPTKDWECHCGKYKRVRYKGVVCDRCGVEVTRAKVRRERMGHIELAAPVS HIWYFKGIPSRMGLVLDMSPRALEEVIYFASYVVTDPANTPLEKKQLLSEKEYRAYLD KYGNKFQASMGAEAIHKLLQDIDLVKEVDMLKEELKTSQGQRRTRAIKRLEVLEAFRN SGNKPSWMILDVLPVIPPELRPMVQLDGGRFATSDLNDLYRRVINRNNRLKRLLDLGA PSIIVQNEKRMLQEAVDALIDNGRRGRPVTGPGNRPLKSLSHMLKGKQGRFRQNLLGK RVDYSGRSVIVVGPHLKMYQCGLPKEMALELFKPFVMKELVEKGLAHNIKSAKRKIER VQPEVWDVLESVIKEHPVLLNRAPTLHRLGIQAFEPTLVEGRAIRLHPLVCTAYNADF DGDQMAVHVPLSAEAQAEARILMLAAQNILNPKDGKPVVTPSQDMVLGNYYLTLERAG AVGEGMVFKNTDEALLAYQNGYVHLHTRVAVAANSLKNVTFTEEQRSKLLITTVGKLV FNEILPESFPYMNEPTKSNIEEKTPDRFFLEKGADVKAVIAQQPINAPFKKGILGKII AEIFKRFHITETSKMLDRMKNLGFKYSTKAGITVGVSDIVVLDDKQEILEEAQSKVDN VMKQFRRGLITEEERYERVISIWSAAKDVIQGKLMKSLDELNPIYMMSDSGARGNASN FTQLAGMRGLMANPAGRIIELPIKSSFREGLTVLEYFISTHGARKGLADTALKTADSG YLTRRLVDVAQDVIIRETDCGTDRGILAKPLKEGTETIERLEERLIGRFARKQVKHPE TGEVLVNENELIDEDKALEIVEAGIEEVWIRSAFTCNTPHGVCKRCYGRNLATGSDVE VGEAVGIIAAQSIGEPGTQLTMRTFHTGGVAGDDITQGLPRIQELFEARNPKGQATIT EIDGTVVEINEVRDKQQEIVVQGAVETRSYTAPYNSRLKVAEGDKITRGQVLTEGSID PKELLKVTDLTTVQEYLLHEVQKVYRMQGVEIGDKHVEVMVRQMLRKVRVIDAGDTDV LPGTLLDIHQFTEANKKVLLEGNRPATGRPVLLGITKASLETDSFLSAASFQETTRVL TDAAIKGKRDELLGLKENVIIGKLVPAGTGMMKYRKVKPVSNVQPTDDMVPVE*" /label="rpoC CDS" gene 125153..128752 /gene="rpoC" /locus_tag="BSU_01080" /old_locus_tag="BSU01080" /label="rpoC gene" downshifts complement(128217) /Source="Nicolas_upshifts" /id="D46" /incds=1 /nref=1 /ntot=76 /MaxReadThrough="3.40002" /MaxDrop="2.38911" /score="-2.05539956" /energy="-7.5" /TU="U93" /idTUdmin="U93" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" upshifts complement(128371) /Source="Nicolas_upshifts" /id="U93" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.952047952047952" /psig="0.000999000999001" /xcortree=64 /SigmaFactorBS="caatgtacctggaagcacatcagtgtcaccggcatcaatcaC Gcgtactttgcgaagcatctggcgaaccattacttctacgtgtttatcaccgatttca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(128389..128390) /Source="Nicolas_upshift_promotors" /id="U93" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.952047952047952" /psig="0.000999000999001" /xcortree=64 /SigmaFactorBS="caatgtacctggaagcacatcagtgtcaccggcatcaatcaC Gcgtactttgcgaagcatctggcgaaccattacttctacgtgtttatcaccgatttca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" downshifts complement(128701) /Source="Nicolas_upshifts" /id="D47" /incds=0 /nref=98 /ntot=210 /MaxReadThrough="1.61828" /MaxDrop="4.90549" /score="-2.05539956" /energy="-7.5" /TU="NA" /idTUdmin="U95" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 128753..128874 /Source="Nicolas_S_feature" /locus_tag="new_129162_129283" /HighExp="LoTm, HiOs, S3, SMMPr, Heat, S1, BC, Glu, S4, MG 45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 1" /TUlongSig="SigA, SigK, SigA, SigWXY, SigA, SigB, SigA" /TUlongPSig="1, 1, 0.999, 1, 1, 1, 0.947" /label="S52" promotor_-35 128856..128863 /Source="Nicolas_upshift_promotors" /id="U94" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.781218781218781" /psig=1 /xcortree=2650 /SigmaFactorBS="cactctatgagaagaacgaatctaaaaaatgtcataccttGT TGACATtcgtctcctagaaTGATAATATAACCAAGGTGCtcgaaataaacctgttact t" /listShort="rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-35" upshifts 128876 /Source="Nicolas_upshifts" /id="U94" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.781218781218781" /psig=1 /xcortree=2650 /SigmaFactorBS="cactctatgagaagaacgaatctaaaaaatgtcataccttGT TGACATtcgtctcctagaaTGATAATATAACCAAGGTGCtcgaaataaacctgttact t" /listShort="rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="upshifts" promotor_-10 128877..128896 /Source="Nicolas_upshift_promotors" /id="U94" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.781218781218781" /psig=1 /xcortree=2650 /SigmaFactorBS="cactctatgagaagaacgaatctaaaaaatgtcataccttGT TGACATtcgtctcctagaaTGATAATATAACCAAGGTGCtcgaaataaacctgttact t" /listShort="rplGB, S53, rpsL, rpsG, fusA, S54, tufA, ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_-10" misc_feature complement(128894..128898) /Source="Nicolas_upshift_promotors" /id="U95" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.909090909090909" /psig="0.023976023976024" /xcortree=67 /SigmaFactorBS="ggcctgtgatactttatcataagacataaacatatcctccaa agtaacaggtttatttcGAGCAccttggttatattatcattctaggagacgaatgtca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(128897) /Source="Nicolas_upshifts" /id="U95" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.909090909090909" /psig="0.023976023976024" /xcortree=67 /SigmaFactorBS="ggcctgtgatactttatcataagacataaacatatcctccaa agtaacaggtttatttcGAGCAccttggttatattatcattctaggagacgaatgtca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 128931..129179 /gene="rulS" /locus_tag="BSU_01090" /old_locus_tag="BSU01090" /function="16.8: Protect" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11574053, 11948165, 17468242, 7657605, 22355167, 23249744, 24204571, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11574053, 11948165, 17468242, 7657605, 22355167, 23249744, 24204571, 22720735; Product type s: structure" /codon_start=1 /transl_table=11 /product="K-turn RNA binding protein; alternative ribosomal protein L7A" /protein_id="NP_387990.1" /db_xref="EnsemblGenomes-Gn:BSU01090" /db_xref="EnsemblGenomes-Tr:CAB11885" /db_xref="GOA:P46350" /db_xref="InterPro:IPR000948" /db_xref="InterPro:IPR004038" /db_xref="InterPro:IPR023460" /db_xref="InterPro:IPR029064" /db_xref="PDB:3V7E" /db_xref="PDB:4LCK" /db_xref="PDB:4TZP" /db_xref="PDB:4TZV" /db_xref="PDB:4TZW" /db_xref="PDB:4TZZ" /db_xref="SubtiList:BG11365" /db_xref="UniProtKB/Swiss-Prot:P46350" /translation="MSYDKVSQAKSIIIGTKQTVKALKRGSVKEVVVAKDADPILTSS VVSLAEDQGISVSMVESMKKLGKACGIEVGAAAVAIIL*" /label="rulS CDS" gene 128931..129179 /gene="rulS" /locus_tag="BSU_01090" /old_locus_tag="BSU01090" /label="rulS gene" S_feature 129180..129292 /Source="Nicolas_S_feature" /locus_tag="new_129589_129701" /HighExp="T-3.40H, M/G, T-1.40H, T-5.40H, Salt, Mal, T-0.40H, G/S, M9-exp, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 0.997, 1" /TUlongSig="SigA, SigK, SigA, SigWXY, SigA, SigB, SigA" /TUlongPSig="1, 1, 0.999, 1, 1, 1, 0.947" /label="S53" CDS 129293..129709 /gene="rpsL" /locus_tag="BSU_01100" /old_locus_tag="BSU01100" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11489846, 12682299, 16484214, 18252828, 19383706, 20007320" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11489846, 12682299, 16484214, 18252828, 19383706, 20007320; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S12 (BS12)" /protein_id="NP_387991.2" /db_xref="EnsemblGenomes-Gn:BSU01100" /db_xref="EnsemblGenomes-Tr:CAB11886" /db_xref="GOA:P21472" /db_xref="InterPro:IPR005679" /db_xref="InterPro:IPR006032" /db_xref="InterPro:IPR012340" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG19009" /db_xref="UniProtKB/Swiss-Prot:P21472" /translation="MPTINQLIRKGRVSKVENSKSPALNKGYNSFKKEHTNVSSPQKR GVCTRVGTMTPKKPNSALRKYARVRLTNGIEVTAYIPGIGHNLQEHSVVLIRGGRVKD LPGVRYHIVRGALDTAGVENRAQGRSKYGTKKPKAK*" /label="rpsL CDS" gene 129293..129709 /gene="rpsL" /locus_tag="BSU_01100" /old_locus_tag="BSU01100" /label="rpsL gene" CDS 129751..130221 /gene="rpsG" /locus_tag="BSU_01110" /old_locus_tag="BSU01110" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8722036, 12682299, 19653700" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8722036, 12682299, 19653700; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S7 (BS7)" /protein_id="NP_387992.2" /db_xref="EnsemblGenomes-Gn:BSU01110" /db_xref="EnsemblGenomes-Tr:CAB11887" /db_xref="GOA:P21469" /db_xref="InterPro:IPR000235" /db_xref="InterPro:IPR005717" /db_xref="InterPro:IPR020606" /db_xref="InterPro:IPR023798" /db_xref="InterPro:IPR036823" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG19006" /db_xref="UniProtKB/Swiss-Prot:P21469" /translation="MPRKGPVAKRDVLPDPIYNSKLVSRLINKMMIDGKKGKSQTILY KSFDIIKERTGNDAMEVFEQALKNIMPVLEVKARRVGGANYQVPVEVRPERRTTLGLR WLVNYARLRGEKTMEERLANEILDAANNTGAAVKKREDTHKMAEANKAFAHYRW*" /label="rpsG CDS" gene 129751..130221 /gene="rpsG" /locus_tag="BSU_01110" /old_locus_tag="BSU01110" /label="rpsG gene" CDS 130275..132353 /gene="fusA" /locus_tag="BSU_01120" /old_locus_tag="BSU01120" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:815236, 815243, 1556067, 4629789, 19366171, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 815236, 815243, 1556067, 4629789, 19366171, 22720735; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="elongation factor G" /protein_id="NP_387993.2" /db_xref="EnsemblGenomes-Gn:BSU01120" /db_xref="EnsemblGenomes-Tr:CAB11888" /db_xref="GOA:P80868" /db_xref="InterPro:IPR000640" /db_xref="InterPro:IPR000795" /db_xref="InterPro:IPR004161" /db_xref="InterPro:IPR004540" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR005517" /db_xref="InterPro:IPR009000" /db_xref="InterPro:IPR009022" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031157" /db_xref="InterPro:IPR035647" /db_xref="InterPro:IPR035649" /db_xref="PDB:5VH6" /db_xref="SubtiList:BG11939" /db_xref="UniProtKB/Swiss-Prot:P80868" /translation="MAREFSLEKTRNIGIMAHIDAGKTTTTERILFYTGRIHKIGETH EGASQMDWMEQEQERGITITSAATTAQWKGYRVNIIDTPGHVDFTVEVERSLRVLDGA VAVLDAQSGVEPQTETVWRQATTYGVPRIVFVNKMDKIGADFLYSVGTLRDRLQANAH AIQLPIGAEDNFEGIIDLVENVAYFYEDDLGTRSDAKEIPEEYKEQAEELRNSLIEAV CELDEELMDKYLEGEEITIDELKAGIRKGTLNVEFYPVLVGSAFKNKGVQLVLDAVLD YLPAPTDVAAIKGTRPDTNEEIERHSSDEEPFSALAFKVMTDPYVGKLTFFRVYSGTL DSGSYVKNSTKGKRERVGRILQMHANSREEISTVYAGDIAAAVGLKDTTTGDTLCDEK DLVILESMEFPEPVIDVAIEPKSKADQDKMGIALAKLAEEDPTFRTQTNPETGQTIIS GMGELHLDIIVDRMKREFKVEANVGAPQVAYRETFRTGAKVEGKFVRQSGGRGQFGHV WIEFEPNEEGAGFEFENAIVGGVVPREYIPAVQAGLEDALENGVLAGFPLIDIKAKLF DGSYHDVDSNEMAFKVAASMALKNAVSKCNPVLLEPIMKVEVVIPEEYMGDIMGDITS RRGRVEGMEARGNAQVVRAMVPLAEMFGYATALRSNTQGRGTFTMHMDHYEEVPKSVA EEIIKKNKGE*" /label="fusA CDS" gene 130275..132353 /gene="fusA" /locus_tag="BSU_01120" /old_locus_tag="BSU01120" /label="fusA gene" S_feature 132354..132472 /Source="Nicolas_S_feature" /locus_tag="new_132763_132881" /HighExp="T-5.40H, T-4.40H, UNK1, SMM, HiTm, T-3.40H, T-2.40H, SMMPr, MG 90, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 0.997, 1" /TUlongSig="SigA, SigK, SigA, SigWXY, SigA, SigB, SigA" /TUlongPSig="1, 1, 0.999, 1, 1, 1, 0.947" /label="S54" CDS 132473..133663 /gene="tufA" /locus_tag="BSU_01130" /old_locus_tag="BSU01130" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10774755, 12682299, 7706132, 20133608, 22938038, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10774755, 12682299, 7706132, 20133608, 22938038, 22720735; Product type f : factor" /codon_start=1 /transl_table=11 /product="elongation factor Tu" /protein_id="NP_387994.1" /db_xref="EnsemblGenomes-Gn:BSU01130" /db_xref="EnsemblGenomes-Tr:CAB11889" /db_xref="GOA:P33166" /db_xref="InterPro:IPR000795" /db_xref="InterPro:IPR004160" /db_xref="InterPro:IPR004161" /db_xref="InterPro:IPR004541" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR009000" /db_xref="InterPro:IPR009001" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031157" /db_xref="InterPro:IPR033720" /db_xref="SubtiList:BG11056" /db_xref="UniProtKB/Swiss-Prot:P33166" /translation="MAKEKFDRSKSHANIGTIGHVDHGKTTLTAAITTVLHKKSGKGT AMAYDQIDGAPEERERGITISTAHVEYETETRHYAHVDCPGHADYVKNMITGAAQMDG AILVVSAADGPMPQTREHILLSKNVGVPYIVVFLNKCDMVDDEELLELVEMEVRDLLS EYDFPGDDVPVVKGSALKALEGDAEWEAKIFELMDAVDEYIPTPERDTEKPFMMPVED VFSITGRGTVATGRVERGQVKVGDEVEIIGLQEENKKTTVTGVEMFRKLLDYAEAGDN IGALLRGVSREEIQRGQVLAKPGTITPHSKFKAEVYVLSKEEGGRHTPFFSNYRPQFY FRTTDVTGIIHLPEGVEMVMPGDNTEMNVELISTIAIEEGTRFSIREGGRTVGSGVVS TITE*" /label="tufA CDS" gene 132473..133663 /gene="tufA" /locus_tag="BSU_01130" /old_locus_tag="BSU01130" /label="tufA gene" downshifts 133658 /Source="Nicolas_upshifts" /id="D48" /incds=0 /nref=258 /ntot=269 /MaxReadThrough="4.84568" /MaxDrop="8.56168" /score="39.3984056" /energy="-12.9" /TU="U88,U90,U94" /idTUdmin="U88" /TUdmin="-1081" /isTUend="FALSE" /label="downshifts" misc_feature complement(133689..133692) /Source="Nicolas_upshift_promotors" /id="U96" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.917082917082917" /psig="0.001998001998002" /xcortree=68 /SigmaFactorBS="acccctcgaatatgatagatcctattatacaagaaaaagata agcaaacaaaaaacgagacCCACaggggtctcgtttaaaaccatactattactcagtg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(133693) /Source="Nicolas_upshifts" /id="U96" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.917082917082917" /psig="0.001998001998002" /xcortree=68 /SigmaFactorBS="acccctcgaatatgatagatcctattatacaagaaaaagata agcaaacaaaaaacgagacCCACaggggtctcgtttaaaaccatactattactcagtg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 133719..133738 /Source="Nicolas_upshift_promotors" /id="U97" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=1878 /SigmaFactorBS="tatggttttaaacgagacccctgtgggtctcgttttttgttt gcttatctttTTCTTGTATAATAGGATCTAtcatattcgaggggttaatatttatgat t" /listShort="ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 133727 /Source="Nicolas_upshifts" /id="U97" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=1878 /SigmaFactorBS="tatggttttaaacgagacccctgtgggtctcgttttttgttt gcttatctttTTCTTGTATAATAGGATCTAtcatattcgaggggttaatatttatgat t" /listShort="ybaC" /listLong="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /label="upshifts" CDS 133762..134718 /gene="ybaC" /locus_tag="BSU_01140" /old_locus_tag="BSU01140" /EC_number="3.4.11.5" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative proline iminopeptidase" /protein_id="NP_387995.2" /db_xref="EnsemblGenomes-Gn:BSU01140" /db_xref="EnsemblGenomes-Tr:CAB11890" /db_xref="GOA:P70981" /db_xref="InterPro:IPR002410" /db_xref="InterPro:IPR022742" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG11988" /db_xref="UniProtKB/Swiss-Prot:P70981" /translation="MIPEKKSIAIMKELSIGNTKQMLMINGVDVKNPLLLFLHGGPGT PQIGYVRHYQKELEQYFTVVHWDQRGSGLSYSKRISHHSMTINHFIKDTIQVTQWLLA HFSKSKLYLAGHSWGSILALHVLQQRPDLFYTYYGISQVVNPQDEESTAYQHIREISE SKKASILSFLTRFIGAPPWKQDIQHLIYRFCVELTRGGFTHRHRQSLAVLFQMLTGNE YGVRNMHSFLNGLRFSKKHLTDELYRFNAFTSVPSIKVPCVFISGKHDLIVPAEISKQ YYQELEAPEKRWFQFENSAHTPHIEEPSLFANTLSRHARHHL*" /label="ybaC CDS" gene 133762..134718 /gene="ybaC" /locus_tag="BSU_01140" /old_locus_tag="BSU01140" /label="ybaC gene" promotor_-35 134725..134732 /Source="Nicolas_upshift_promotors" /id="U98" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=2656 /SigmaFactorBS="gcacgacaccatttatgatagatcCTTGATAAataagaaaaa cccCTGTATAATAAAAAAAGTGTgcaaatcatgcatattttaaataagtcttgcaaca t" /listShort="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 134746..134765 /Source="Nicolas_upshift_promotors" /id="U98" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=2656 /SigmaFactorBS="gcacgacaccatttatgatagatcCTTGATAAataagaaaaa cccCTGTATAATAAAAAAAGTGTgcaaatcatgcatattttaaataagtcttgcaaca t" /listShort="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 134761..134954 /Source="Nicolas_S_feature" /locus_tag="new_135170_135363" /HighExp="T-1.40H, T-2.40H, T-1.10H, SMM, T-3.40H, T-4.40H, BI, BMM, H2O2, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA, SigA, SigA, SigA, SigA, SigWXY, SigA, SigA" /TUlongPSig="1, 1, 0.997, 1, 1, 0.999, 1, 1, 0.947" /label="S55" upshifts 134761 /Source="Nicolas_upshifts" /id="U98" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=2656 /SigmaFactorBS="gcacgacaccatttatgatagatcCTTGATAAataagaaaaa cccCTGTATAATAAAAAAAGTGTgcaaatcatgcatattttaaataagtcttgcaaca t" /listShort="S55, rpsJ, rplC, rplD, rplW, rplB, rpsS, rplV, rpsC, rplP, rpmC, rpsQ, rplNA, rplX, rplE, rpsNA, rpsH, rplF, rplR, rpsE, rpmD, rplO, secY, adk, mapA, ybzG, infA, rpmJ, rpsM, rpsK, S56, rpoA, rplQ, S57, ybxA, ybaE, ybaF, truA, NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" /label="upshifts" CDS 134955..135263 /gene="rpsJ" /locus_tag="BSU_01150" /old_locus_tag="BSU01150" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 27964882" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 27964882; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S10 (BS13); transcription antitermination factor" /protein_id="NP_387996.1" /db_xref="EnsemblGenomes-Gn:BSU01150" /db_xref="EnsemblGenomes-Tr:CAB11891" /db_xref="GOA:P21471" /db_xref="InterPro:IPR001848" /db_xref="InterPro:IPR018268" /db_xref="InterPro:IPR027486" /db_xref="InterPro:IPR036838" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG19008" /db_xref="UniProtKB/Swiss-Prot:P21471" /translation="MAKQKIRIRLKAYDHRILDQSAEKIVETAKRSGASVSGPIPLPT EKSVYTILRAVHKYKDSREQFEMRTHKRLIDIVNPTPQTVDALMRLDLPSGVDIEIKL *" /label="rpsJ CDS" gene 134955..135263 /gene="rpsJ" /locus_tag="BSU_01150" /old_locus_tag="BSU01150" /label="rpsJ gene" CDS 135303..135932 /gene="rplC" /locus_tag="BSU_01160" /old_locus_tag="BSU01160" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 17981968, 19154332, 23759864" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17981968, 19154332, 23759864; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L3 (BL3)" /protein_id="NP_387997.1" /db_xref="EnsemblGenomes-Gn:BSU01160" /db_xref="EnsemblGenomes-Tr:CAB11892" /db_xref="GOA:P42920" /db_xref="InterPro:IPR000597" /db_xref="InterPro:IPR009000" /db_xref="InterPro:IPR019926" /db_xref="InterPro:IPR019927" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11218" /db_xref="UniProtKB/Swiss-Prot:P42920" /translation="MTKGILGRKIGMTQVFAENGDLIPVTVIEAAPNVVLQKKTAEND GYEAIQLGFDDKREKLSNKPEKGHVAKAETAPKRFVKELRGVEMDAYEVGQEVKVEIF SAGEIVDVTGVSKGKGFQGAIKRHGQSRGPMSHGSRYHRRPGSMGPVDPNRVFKGKLL PGRMGGEQITVQNLEIVKVDAERNLLLIKGNVPGAKKSLITVKSAVKSK*" /label="rplC CDS" gene 135303..135932 /gene="rplC" /locus_tag="BSU_01160" /old_locus_tag="BSU01160" /label="rplC gene" CDS 135960..136583 /gene="rplD" /locus_tag="BSU_01170" /old_locus_tag="BSU01170" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10898684, 12682299, 22720735; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L4" /protein_id="NP_387998.1" /db_xref="EnsemblGenomes-Gn:BSU01170" /db_xref="EnsemblGenomes-Tr:CAB11893" /db_xref="GOA:P42921" /db_xref="InterPro:IPR002136" /db_xref="InterPro:IPR013005" /db_xref="InterPro:IPR023574" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11219" /db_xref="UniProtKB/Swiss-Prot:P42921" /translation="MPKVALYNQNGSTAGDIELNASVFGIEPNESVVFDAILMQRASL RQGTHKVKNRSEVRGGGRKPWRQKGTGRARQGSIRSPQWRGGGVVFGPTPRSYSYKLP KKVRRLAIKSVLSSKVIDNNIIVLEDLTLDTAKTKEMAAILKGLSVEKKALIVTADAN EAVALSARNIPGVTVVEANGINVLDVVNHEKLLITKAAVEKVEEVLA*" /label="rplD CDS" gene 135960..136583 /gene="rplD" /locus_tag="BSU_01170" /old_locus_tag="BSU01170" /label="rplD gene" CDS 136583..136870 /gene="rplW" /locus_tag="BSU_01180" /old_locus_tag="BSU01180" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 17981968, 23002217" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17981968, 23002217; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L23" /protein_id="NP_387999.2" /db_xref="EnsemblGenomes-Gn:BSU01180" /db_xref="EnsemblGenomes-Tr:CAB11894" /db_xref="GOA:P42924" /db_xref="InterPro:IPR001014" /db_xref="InterPro:IPR012678" /db_xref="InterPro:IPR013025" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11221" /db_xref="UniProtKB/Swiss-Prot:P42924" /translation="MKDPRDVLKRPVITERSADLMTEKKYTFEVDVRANKTEVKDAVE SIFGVKVDKVNIMNYKGKSKRVGRYTGMTSRRRKAIVKLTADSKEIEIFEA*" /label="rplW CDS" gene 136583..136870 /gene="rplW" /locus_tag="BSU_01180" /old_locus_tag="BSU01180" /label="rplW gene" CDS 136902..137735 /gene="rplB" /locus_tag="BSU_01190" /old_locus_tag="BSU01190" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 23249812, 24637032" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 23249812, 24637032; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L2 (BL2)" /protein_id="NP_388000.2" /db_xref="EnsemblGenomes-Gn:BSU01190" /db_xref="EnsemblGenomes-Tr:CAB11895" /db_xref="GOA:P42919" /db_xref="InterPro:IPR002171" /db_xref="InterPro:IPR005880" /db_xref="InterPro:IPR008991" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR014722" /db_xref="InterPro:IPR014726" /db_xref="InterPro:IPR022666" /db_xref="InterPro:IPR022669" /db_xref="InterPro:IPR022671" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11217" /db_xref="UniProtKB/Swiss-Prot:P42919" /translation="MAIKKYKPTSNGRRGMTTSDFAEITTDKPEKSLLAPLHKKGGRN NQGKLTVRHQGGGHKRQYRVIDFKRDKDGIPGRVATVEYDPNRSANIALINYADGEKR YILAPKGIQVGTEIMSGPEADIKVGNALPLINIPVGTVVHNIELKPGKGGQLVRSAGT SAQVLGKEGKYVLVRLNSGEVRMILSACRASIGQVGNEQHELINIGKAGRSRWKGIRP TVRGSVMNPNDHPHGGGEGRAPIGRKSPMSPWGKPTLGFKTRKKKNKSDKFIVRRRKN K*" /label="rplB CDS" gene 136902..137735 /gene="rplB" /locus_tag="BSU_01190" /old_locus_tag="BSU01190" /label="rplB gene" downshifts complement(137038) /Source="Nicolas_upshifts" /id="D49" /incds=1 /nref=1 /ntot=47 /MaxReadThrough="3.39972" /MaxDrop="4.09052" /score="-4.16840603" /energy="-12.8" /TU="NA" /idTUdmin="U99" /TUdmin=1342 /isTUend="FALSE" /label="downshifts" CDS 137793..138071 /gene="rpsS" /locus_tag="BSU_01200" /old_locus_tag="BSU01200" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S19 (BS19)" /protein_id="NP_388001.1" /db_xref="EnsemblGenomes-Gn:BSU01200" /db_xref="EnsemblGenomes-Tr:CAB11896" /db_xref="GOA:P21476" /db_xref="InterPro:IPR002222" /db_xref="InterPro:IPR005732" /db_xref="InterPro:IPR020934" /db_xref="InterPro:IPR023575" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG19011" /db_xref="UniProtKB/Swiss-Prot:P21476" /translation="MARSLKKGPFVDGHLMTKIEKLNETDKKQVVKTWSRRSTIFPQF IGHTIAVYDGRKHVPVFISEDMVGHKLGEFAPTRTYKGHASDDKKTRR*" /label="rpsS CDS" gene 137793..138071 /gene="rpsS" /locus_tag="BSU_01200" /old_locus_tag="BSU01200" /label="rpsS gene" CDS 138088..138429 /gene="rplV" /locus_tag="BSU_01210" /old_locus_tag="BSU01210" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7928988, 12682299, 23002217" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7928988, 12682299, 23002217; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L22 (BL17)" /protein_id="NP_388002.1" /db_xref="EnsemblGenomes-Gn:BSU01210" /db_xref="EnsemblGenomes-Tr:CAB11897" /db_xref="GOA:P42060" /db_xref="InterPro:IPR001063" /db_xref="InterPro:IPR005727" /db_xref="InterPro:IPR018260" /db_xref="InterPro:IPR036394" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11078" /db_xref="UniProtKB/Swiss-Prot:P42060" /translation="MQAKAVARTVRIAPRKARLVMDLIRGKQVGEAVSILNLTPRAAS PIIEKVLKSAIANAEHNYEMDANNLVISQAFVDEGPTLKRFRPRAMGRASQINKRTSH ITIVVSEKKEG*" /label="rplV CDS" gene 138088..138429 /gene="rplV" /locus_tag="BSU_01210" /old_locus_tag="BSU01210" /label="rplV gene" CDS 138433..139089 /gene="rpsC" /locus_tag="BSU_01220" /old_locus_tag="BSU01220" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S3 (BS3)" /protein_id="NP_388003.2" /db_xref="EnsemblGenomes-Gn:BSU01220" /db_xref="EnsemblGenomes-Tr:CAB11898" /db_xref="GOA:P21465" /db_xref="InterPro:IPR001351" /db_xref="InterPro:IPR004044" /db_xref="InterPro:IPR004087" /db_xref="InterPro:IPR005704" /db_xref="InterPro:IPR009019" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR018280" /db_xref="InterPro:IPR036419" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG19005" /db_xref="UniProtKB/Swiss-Prot:P21465" /translation="MGQKVNPVGLRIGVIRDWESKWYAGKDYADFLHEDLKIREYISK RLSDASVSKVEIERAANRVNITIHTAKPGMVIGKGGSEVEALRKALNSLTGKRVHINI LEIKRADLDAQLVADNIARQLENRVSFRRAQKQQIQRTMRAGAQGVKTMVSGRLGGAD IARSEYYSEGTVPLHTLRADIDYATSEADTTYGKLGVKVWIYRGEVLPTKKKNEEGGK *" /label="rpsC CDS" gene 138433..139089 /gene="rpsC" /locus_tag="BSU_01220" /old_locus_tag="BSU01220" /label="rpsC gene" downshifts complement(138446) /Source="Nicolas_upshifts" /id="D50" /incds=0 /nref=1 /ntot=62 /MaxReadThrough="3.68388" /MaxDrop="2.1922" /score="-4.16840603" /energy="-12.8" /TU="U99" /idTUdmin="U99" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(138527..138531) /Source="Nicolas_upshift_promotors" /id="U99" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.972027972027972" /psig="0.00999000999001" /xcortree=77 /SigmaFactorBS="tactttagaaacagaagcgtcagaaaggcgtttgctaatgta ttCACgaatttttaaatcttcGTGCAggaagtcagcgtaatctttaccagcgtaccac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(138534) /Source="Nicolas_upshifts" /id="U99" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.972027972027972" /psig="0.00999000999001" /xcortree=77 /SigmaFactorBS="tactttagaaacagaagcgtcagaaaggcgtttgctaatgta ttCACgaatttttaaatcttcGTGCAggaagtcagcgtaatctttaccagcgtaccac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(138548..138550) /Source="Nicolas_upshift_promotors" /id="U99" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.972027972027972" /psig="0.00999000999001" /xcortree=77 /SigmaFactorBS="tactttagaaacagaagcgtcagaaaggcgtttgctaatgta ttCACgaatttttaaatcttcGTGCAggaagtcagcgtaatctttaccagcgtaccac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 139091..139525 /gene="rplP" /locus_tag="BSU_01230" /old_locus_tag="BSU01230" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 16390447, 24335279" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16390447, 24335279; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L16" /protein_id="NP_388004.1" /db_xref="EnsemblGenomes-Gn:BSU01230" /db_xref="EnsemblGenomes-Tr:CAB11899" /db_xref="GOA:P14577" /db_xref="InterPro:IPR000114" /db_xref="InterPro:IPR016180" /db_xref="InterPro:IPR020798" /db_xref="InterPro:IPR036920" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10755" /db_xref="UniProtKB/Swiss-Prot:P14577" /translation="MLLPKRVKYRREHRGKMRGRAKGGTEVHFGEFGIQALEASWITN RQIEAARIAMTRYMKRGGKVWIKIFPSKPYTAKPLEVRMGSGKGAPEGWVAVVKPGKV LFEISGVSEEVAREALRLASHKLPIKTKFVKREEIGGESNES*" /label="rplP CDS" gene 139091..139525 /gene="rplP" /locus_tag="BSU_01230" /old_locus_tag="BSU01230" /label="rplP gene" CDS 139515..139715 /gene="rpmC" /locus_tag="BSU_01240" /old_locus_tag="BSU01240" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 23002217" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 23002217; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L29" /protein_id="NP_388005.1" /db_xref="EnsemblGenomes-Gn:BSU01240" /db_xref="EnsemblGenomes-Tr:CAB11900" /db_xref="GOA:P12873" /db_xref="InterPro:IPR001854" /db_xref="InterPro:IPR018254" /db_xref="InterPro:IPR036049" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10756" /db_xref="UniProtKB/Swiss-Prot:P12873" /translation="MKANEIRDLTTAEIEQKVKSLKEELFNLRFQLATGQLENTARIR EVRKAIARMKTVIREREIAANK*" /label="rpmC CDS" gene 139515..139715 /gene="rpmC" /locus_tag="BSU_01240" /old_locus_tag="BSU01240" /label="rpmC gene" CDS 139738..140001 /gene="rpsQ" /locus_tag="BSU_01250" /old_locus_tag="BSU01250" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S17 (BS16)" /protein_id="NP_388006.1" /db_xref="EnsemblGenomes-Gn:BSU01250" /db_xref="EnsemblGenomes-Tr:CAB11901" /db_xref="GOA:P12874" /db_xref="InterPro:IPR000266" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR019979" /db_xref="InterPro:IPR019984" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10757" /db_xref="UniProtKB/Swiss-Prot:P12874" /translation="MSERNQRKVYQGRVVSDKMDKTITVVVETYKKHTLYGKRVKYSK KFKAHDENNQAKIGDIVKIMETRPLSATKRFRLVEVVEEAVII*" /label="rpsQ CDS" gene 139738..140001 /gene="rpsQ" /locus_tag="BSU_01250" /old_locus_tag="BSU01250" /label="rpsQ gene" CDS 140042..140410 /gene="rplNA" /locus_tag="BSU_01260" /old_locus_tag="BSU01260" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8722036, 8805509, 12682299, 22829778" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8722036, 8805509, 12682299, 22829778; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L14" /protein_id="NP_388007.1" /db_xref="EnsemblGenomes-Gn:BSU01260" /db_xref="EnsemblGenomes-Tr:CAB11902" /db_xref="GOA:P12875" /db_xref="InterPro:IPR000218" /db_xref="InterPro:IPR005745" /db_xref="InterPro:IPR019972" /db_xref="InterPro:IPR036853" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10758" /db_xref="UniProtKB/Swiss-Prot:P12875" /translation="MIQQETRLKVADNSGAREVLTIKVLGGSGRKTANIGDVIVCTVK QATPGGVVKKGEVVKAVIVRTKSGARRSDGSYISFDENACVIIRDDKSPRGTRIFGPV ARELRENNFMKIVSLAPEVI*" /label="rplNA CDS" gene 140042..140410 /gene="rplNA" /locus_tag="BSU_01260" /old_locus_tag="BSU01260" /label="rplNA gene" CDS 140448..140759 /gene="rplX" /locus_tag="BSU_01270" /old_locus_tag="BSU01270" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11278078, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11278078, 12682299; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L24 (BL23)" /protein_id="NP_388008.1" /db_xref="EnsemblGenomes-Gn:BSU01270" /db_xref="EnsemblGenomes-Tr:CAB11903" /db_xref="GOA:P0CI78" /db_xref="InterPro:IPR003256" /db_xref="InterPro:IPR005824" /db_xref="InterPro:IPR005825" /db_xref="InterPro:IPR008991" /db_xref="InterPro:IPR014722" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10759" /db_xref="UniProtKB/Swiss-Prot:P0CI78" /translation="MHVKKGDKVMVISGKDKGKQGTILAAFPKKDRVLVEGVNMVKKH SKPTQANPQGGISNQEAPIHVSNVMPLDPKTGEVTRVGYKVEDGKKVRVAKKSGQVLD K*" /label="rplX CDS" gene 140448..140759 /gene="rplX" /locus_tag="BSU_01270" /old_locus_tag="BSU01270" /label="rplX gene" CDS 140786..141325 /gene="rplE" /locus_tag="BSU_01280" /old_locus_tag="BSU01280" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L5 (BL6)" /protein_id="NP_388009.1" /db_xref="EnsemblGenomes-Gn:BSU01280" /db_xref="EnsemblGenomes-Tr:CAB11904" /db_xref="GOA:P12877" /db_xref="InterPro:IPR002132" /db_xref="InterPro:IPR020929" /db_xref="InterPro:IPR020930" /db_xref="InterPro:IPR022803" /db_xref="InterPro:IPR031309" /db_xref="InterPro:IPR031310" /db_xref="PDB:3J3V" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10760" /db_xref="UniProtKB/Swiss-Prot:P12877" /translation="MNRLKEKYNKEIAPALMTKFNYDSVMQVPKIEKIVINMGVGDAV QNAKAIDSAVEELTFIAGQKPVVTRAKKSIAGFRLREGMPIGAKVTLRGERMYDFLDK LISVSLPRVRDFRGVSKKSFDGRGNYTLGIKEQLIFPEIDYDKVTKVRGMDIVIVTTA NTDEEARELLTQVGMPFQK*" /label="rplE CDS" gene 140786..141325 /gene="rplE" /locus_tag="BSU_01280" /old_locus_tag="BSU01280" /label="rplE gene" CDS 141348..141533 /gene="rpsNA" /locus_tag="BSU_01290" /old_locus_tag="BSU01290" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 17163968, 19648245, 20208344, 27561249" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17163968, 19648245, 20208344, 27561249; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S14" /protein_id="NP_388010.1" /db_xref="EnsemblGenomes-Gn:BSU01290" /db_xref="EnsemblGenomes-Tr:CAB11905" /db_xref="GOA:P12878" /db_xref="InterPro:IPR001209" /db_xref="InterPro:IPR018271" /db_xref="InterPro:IPR023053" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10761" /db_xref="UniProtKB/Swiss-Prot:P12878" /translation="MAKKSMIAKQQRTPKFKVQEYTRCERCGRPHSVIRKFKLCRICF RELAYKGQIPGVKKASW*" /label="rpsNA CDS" gene 141348..141533 /gene="rpsNA" /locus_tag="BSU_01290" /old_locus_tag="BSU01290" /label="rpsNA gene" CDS 141565..141963 /gene="rpsH" /locus_tag="BSU_01300" /old_locus_tag="BSU01300" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S8 (BS8)" /protein_id="NP_388011.2" /db_xref="EnsemblGenomes-Gn:BSU01300" /db_xref="EnsemblGenomes-Tr:CAB11906" /db_xref="GOA:P12879" /db_xref="InterPro:IPR000630" /db_xref="InterPro:IPR035987" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10762" /db_xref="UniProtKB/Swiss-Prot:P12879" /translation="MVMTDPIADMLTRIRNANMVRHEKLEIPASKLKREIAEILKREG FIRDVEFVEDSKQGIIRVFLKYGQNNERVITGLKRISKPGLRVYAKSNEVPRVLNGLG IAIISTSQGVLTDKEARAKQAGGEVLAYVW*" /label="rpsH CDS" gene 141565..141963 /gene="rpsH" /locus_tag="BSU_01300" /old_locus_tag="BSU01300" /label="rpsH gene" downshifts complement(141966) /Source="Nicolas_upshifts" /id="D51" /incds=0 /nref=1 /ntot=74 /MaxReadThrough="2.68318" /MaxDrop="2.55712" /score="5.40276403" /energy="-15.9" /TU="NA" /idTUdmin="U99" /TUdmin="-3586" /isTUend="FALSE" /label="downshifts" CDS 141993..142532 /gene="rplF" /locus_tag="BSU_01310" /old_locus_tag="BSU01310" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 25330043; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L6 (BL8)" /protein_id="NP_388012.1" /db_xref="EnsemblGenomes-Gn:BSU01310" /db_xref="EnsemblGenomes-Tr:CAB11907" /db_xref="GOA:P46898" /db_xref="InterPro:IPR000702" /db_xref="InterPro:IPR002358" /db_xref="InterPro:IPR019906" /db_xref="InterPro:IPR020040" /db_xref="InterPro:IPR036789" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11408" /db_xref="UniProtKB/Swiss-Prot:P46898" /translation="MSRVGKKLLEIPSDVTVTLNDNNTVAVKGPKGELTRTFHPDMEI KVEDNVLTVARPSDQKEHRALHGTTRSLLGNMVEGVSKGFERGLELVGVGYRASKSGN KLVLNVGYSHPVEIVPEEGIEIEVPSQTKVVVKGTDKERVGAIAANIRAVRSPEPYKG KGIRYEGEVVRRKEGKSAK*" /label="rplF CDS" gene 141993..142532 /gene="rplF" /locus_tag="BSU_01310" /old_locus_tag="BSU01310" /label="rplF gene" CDS 142565..142927 /gene="rplR" /locus_tag="BSU_01320" /old_locus_tag="BSU01320" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L18" /protein_id="NP_388013.2" /db_xref="EnsemblGenomes-Gn:BSU01320" /db_xref="EnsemblGenomes-Tr:CAB11908" /db_xref="GOA:P46899" /db_xref="InterPro:IPR004389" /db_xref="InterPro:IPR005484" /db_xref="PDB:3J3V" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11409" /db_xref="UniProtKB/Swiss-Prot:P46899" /translation="MITKTSKNAARLKRHARVRAKLSGTAERPRLNVFRSNKHIYAQI IDDVNGVTLASASTLDKDLNVESTGDTSAATKVGELVAKRAAEKGISDVVFDRGGYLY HGRVKALADAAREAGLKF*" /label="rplR CDS" gene 142565..142927 /gene="rplR" /locus_tag="BSU_01320" /old_locus_tag="BSU01320" /label="rplR gene" CDS 142952..143452 /gene="rpsE" /locus_tag="BSU_01330" /old_locus_tag="BSU01330" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6211592, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6211592, 12682299; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S5" /protein_id="NP_388014.1" /db_xref="EnsemblGenomes-Gn:BSU01330" /db_xref="EnsemblGenomes-Tr:CAB11909" /db_xref="GOA:P21467" /db_xref="InterPro:IPR000851" /db_xref="InterPro:IPR005324" /db_xref="InterPro:IPR005712" /db_xref="InterPro:IPR013810" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR018192" /db_xref="InterPro:IPR020568" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10442" /db_xref="UniProtKB/Swiss-Prot:P21467" /translation="MRRIDPSKLELEERLVTVNRVAKVVKGGRRFRFAALVVVGDKNG HVGFGTGKAQEVPEAIRKAVEDAKKNLIEVPMVGTTIPHEIIGRFGAGNILLKPASEG TGVIAGGPVRAVLELAGVADILSKSLGSNTPINMIRATLQGLSELKRAEDVAKLRGKS VEELLG*" /label="rpsE CDS" gene 142952..143452 /gene="rpsE" /locus_tag="BSU_01330" /old_locus_tag="BSU01330" /label="rpsE gene" CDS 143466..143645 /gene="rpmD" /locus_tag="BSU_01340" /old_locus_tag="BSU01340" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L30 (BL27)" /protein_id="NP_388015.1" /db_xref="EnsemblGenomes-Gn:BSU01340" /db_xref="EnsemblGenomes-Tr:CAB11910" /db_xref="GOA:P19947" /db_xref="InterPro:IPR005996" /db_xref="InterPro:IPR016082" /db_xref="InterPro:IPR018038" /db_xref="InterPro:IPR036919" /db_xref="PDB:3J3V" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10443" /db_xref="UniProtKB/Swiss-Prot:P19947" /translation="MAKLEITLKRSVIGRPEDQRVTVRTLGLKKTNQTVVHEDNAAIR GMINKVSHLVSVKEQ*" /label="rpmD CDS" gene 143466..143645 /gene="rpmD" /locus_tag="BSU_01340" /old_locus_tag="BSU01340" /label="rpmD gene" CDS 143676..144116 /gene="rplO" /locus_tag="BSU_01350" /old_locus_tag="BSU01350" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15855514, 23002217" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15855514, 23002217; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L15" /protein_id="NP_388016.1" /db_xref="EnsemblGenomes-Gn:BSU01350" /db_xref="EnsemblGenomes-Tr:CAB11911" /db_xref="GOA:P19946" /db_xref="InterPro:IPR001196" /db_xref="InterPro:IPR005749" /db_xref="InterPro:IPR021131" /db_xref="InterPro:IPR030878" /db_xref="InterPro:IPR036227" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10444" /db_xref="UniProtKB/Swiss-Prot:P19946" /translation="MKLHELKPSEGSRKTRNRVGRGIGSGNGKTAGKGHKGQNARSGG GVRPGFEGGQMPLFQRLPKRGFTNINRKEYAVVNLDKLNGFAEGTEVTPELLLETGVI SKLNAGVKILGNGKLEKKLTVKANKFSASAKEAVEAAGGTAEVI*" /label="rplO CDS" gene 143676..144116 /gene="rplO" /locus_tag="BSU_01350" /old_locus_tag="BSU01350" /label="rplO gene" CDS 144118..145413 /gene="secY" /locus_tag="BSU_01360" /old_locus_tag="BSU01360" /function="16.1: Circulate" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9917412, 15341641, 15849754, 16850406, 23852076, 22720735, 27336478" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9917412, 15341641, 15849754, 16850406, 23852076, 22720735, 27336478; Product type t: transporter" /codon_start=1 /transl_table=11 /product="preprotein translocase subunit" /protein_id="NP_388017.1" /db_xref="EnsemblGenomes-Gn:BSU01360" /db_xref="EnsemblGenomes-Tr:CAB11912" /db_xref="GOA:P16336" /db_xref="InterPro:IPR002208" /db_xref="InterPro:IPR023201" /db_xref="InterPro:IPR026593" /db_xref="InterPro:IPR030659" /db_xref="SubtiList:BG10445" /db_xref="UniProtKB/Swiss-Prot:P16336" /translation="MFKTISNFMRVSDIRNKIIFTLLMLIVFRIGAFIPVPYVNAEAL QAQSQMGVFDLLNTFGGGALYQFSIFAMGITPYITASIIIQLLQMDVVPKFTEWSKQG EVGRRKLAQFTRYFTIVLGFIQALGMSYGFNNLANGMLIEKSGVSTYLIIALVLTGGT AFLMWLGEQITSHGVGNGISIIIFAGIVSSIPKTIGQIYETQFVGSNDQLFIHIVKVA LLVIAILAVIVGVIFIQQAVRKIAIQYAKGTGRSPAGGGQSTHLPLKVNPAGVIPVIF AVAFLITPRTIASFFGTNDVTKWIQNNFDNTHPVGMAIYVALIIAFTYFYAFVQVNPE QMADNLKKQGGYIPGVRPGKMTQDRITSILYRLTFVGSIFLAVISILPIFFIQFAGLP QSAQIGGTSLLIVVGVALETMKQLESQLVKRNYRGFMKN*" /label="secY CDS" gene 144118..145413 /gene="secY" /locus_tag="BSU_01360" /old_locus_tag="BSU01360" /label="secY gene" CDS 145468..146121 /gene="adk" /locus_tag="BSU_01370" /old_locus_tag="BSU01370" /EC_number="2.7.4.3" /function="16.2: Construct biomass (Anabolism)" /function="16.7: Manage energy" /experiment="publication(s) with functional evidences, PMID:8061005, 8288548, 9056261, 9715904, 11106368, 16452168" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8061005, 8288548, 9056261, 9715904, 11106368, 16452168; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="adenylate kinase" /protein_id="NP_388018.1" /db_xref="EnsemblGenomes-Gn:BSU01370" /db_xref="EnsemblGenomes-Tr:CAB11913" /db_xref="GOA:P16304" /db_xref="InterPro:IPR000850" /db_xref="InterPro:IPR006259" /db_xref="InterPro:IPR007862" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR033690" /db_xref="PDB:1P3J" /db_xref="PDB:2EU8" /db_xref="PDB:2OO7" /db_xref="PDB:2ORI" /db_xref="PDB:2OSB" /db_xref="PDB:2P3S" /db_xref="PDB:2QAJ" /db_xref="PDB:3DKV" /db_xref="PDB:3DL0" /db_xref="PDB:4MKF" /db_xref="PDB:4MKG" /db_xref="PDB:4MKH" /db_xref="PDB:4QBF" /db_xref="PDB:4QBG" /db_xref="PDB:4TYP" /db_xref="PDB:4TYQ" /db_xref="SubtiList:BG10446" /db_xref="UniProtKB/Swiss-Prot:P16304" /translation="MNLVLMGLPGAGKGTQGERIVEDYGIPHISTGDMFRAAMKEETP LGLEAKSYIDKGELVPDEVTIGIVKERLGKDDCERGFLLDGFPRTVAQAEALEEILEE YGKPIDYVINIEVDKDVLMERLTGRRICSVCGTTYHLVFNPPKTPGICDKDGGELYQR ADDNEETVSKRLEVNMKQTQPLLDFYSEKGYLANVNGQQDIQDVYADVKDLLGGLKK* " /label="adk CDS" gene 145468..146121 /gene="adk" /locus_tag="BSU_01370" /old_locus_tag="BSU01370" /label="adk gene" CDS 146118..146864 /gene="mapA" /locus_tag="BSU_01380" /old_locus_tag="BSU01380" /EC_number="3.4.11.18" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:16207374, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16207374, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methionine aminopeptidase" /protein_id="NP_388019.1" /db_xref="EnsemblGenomes-Gn:BSU01380" /db_xref="EnsemblGenomes-Tr:CAB11914" /db_xref="GOA:P19994" /db_xref="InterPro:IPR000994" /db_xref="InterPro:IPR001714" /db_xref="InterPro:IPR002467" /db_xref="InterPro:IPR036005" /db_xref="SubtiList:BG10447" /db_xref="UniProtKB/Swiss-Prot:P19994" /translation="MIICKTPRELGIMREAGRIVALTHEELKKHIKPGISTKELDQIA ERFIKKQGAIPSFKGYNGFRGSICVSVNEELVHGIPGSRVLKDGDIISIDIGAKLNGY HGDSAWTYPVGNISDDDKKLLEVTEESLYKGLQEAKPGERLSNISHAIQTYVENEQFS VVREYVGHGVGQDLHEDPQIPHYGPPNKGPRLKPGMVLAIEPMVNAGSRYVKTLADNW TVVTVDGKKCAHFEHTIAITETGFDILTRV*" /label="mapA CDS" gene 146118..146864 /gene="mapA" /locus_tag="BSU_01380" /old_locus_tag="BSU01380" /label="mapA gene" CDS 146903..147127 /gene="ybzG" /locus_tag="BSU_01389" /old_locus_tag="BSU01389" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17157877; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative ribosome binding protein" /protein_id="YP_003097669.1" /db_xref="EnsemblGenomes-Gn:BSU01389" /db_xref="EnsemblGenomes-Tr:CAX52539" /db_xref="UniProtKB/Swiss-Prot:C0H3S8" /translation="MIGQKAWVNIGKTEFILLLVVGILTIINVLTADGEKRTFHSPKK KNINHLTLYDCVSPEVQNSINETGRVTNFF*" /label="ybzG CDS" gene 146903..147127 /gene="ybzG" /locus_tag="BSU_01389" /old_locus_tag="BSU01389" /label="ybzG gene" CDS 147176..147394 /gene="infA" /locus_tag="BSU_01390" /old_locus_tag="BSU01390" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9868784, 20477873, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="initiation factor IF-I" /protein_id="NP_388020.1" /db_xref="EnsemblGenomes-Gn:BSU01390" /db_xref="EnsemblGenomes-Tr:CAB11915" /db_xref="GOA:P20458" /db_xref="InterPro:IPR004368" /db_xref="InterPro:IPR006196" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR022967" /db_xref="SubtiList:BG11043" /db_xref="UniProtKB/Swiss-Prot:P20458" /translation="MAKDDVIEVEGTIVETLPNAMFKVELENGHTVLAHVSGKIRMHF IRILPGDKVTVELSPYDLTRGRITYRYK*" /label="infA CDS" gene 147176..147394 /gene="infA" /locus_tag="BSU_01390" /old_locus_tag="BSU01390" /label="infA gene" CDS 147428..147541 /gene="rpmJ" /locus_tag="BSU_01400" /old_locus_tag="BSU01400" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1783905, 23002217, 24335279" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1783905, 23002217, 24335279; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosomal protein L36 (ribosomal protein B)" /protein_id="NP_388021.1" /db_xref="EnsemblGenomes-Gn:BSU01400" /db_xref="EnsemblGenomes-Tr:CAB11916" /db_xref="GOA:P20278" /db_xref="InterPro:IPR000473" /db_xref="InterPro:IPR035977" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11042" /db_xref="UniProtKB/Swiss-Prot:P20278" /translation="MKVRPSVKPICEKCKVIRRKGKVMVICENPKHKQKQG*" /label="rpmJ CDS" gene 147428..147541 /gene="rpmJ" /locus_tag="BSU_01400" /old_locus_tag="BSU01400" /label="rpmJ gene" CDS 147564..147929 /gene="rpsM" /locus_tag="BSU_01410" /old_locus_tag="BSU01410" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 22720735; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S13" /protein_id="NP_388022.2" /db_xref="EnsemblGenomes-Gn:BSU01410" /db_xref="EnsemblGenomes-Tr:CAB11917" /db_xref="GOA:P20282" /db_xref="InterPro:IPR001892" /db_xref="InterPro:IPR010979" /db_xref="InterPro:IPR018269" /db_xref="InterPro:IPR019980" /db_xref="InterPro:IPR027437" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10730" /db_xref="UniProtKB/Swiss-Prot:P20282" /translation="MARIAGVDIPRDKRVVISLTYIFGIGRTTAQQVLKEAGVSEDTR VRDLTEEELGKIRDIIDKLKVEGDLRREVSLNIKRLIEIGSYRGIRHRRGLPVRGQNS KNNARTRKGPRRTVANKKK*" /label="rpsM CDS" gene 147564..147929 /gene="rpsM" /locus_tag="BSU_01410" /old_locus_tag="BSU01410" /label="rpsM gene" CDS 147950..148345 /gene="rpsK" /locus_tag="BSU_01420" /old_locus_tag="BSU01420" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10217780, 12682299, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10217780, 12682299, 22720735; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S11 (BS11)" /protein_id="NP_388023.1" /db_xref="EnsemblGenomes-Gn:BSU01420" /db_xref="EnsemblGenomes-Tr:CAB11918" /db_xref="GOA:P04969" /db_xref="InterPro:IPR001971" /db_xref="InterPro:IPR018102" /db_xref="InterPro:IPR019981" /db_xref="InterPro:IPR036967" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10731" /db_xref="UniProtKB/Swiss-Prot:P04969" /translation="MAAARKSNTRKRRVKKNIESGIAHIRSTFNNTIVTITDTHGNAI SWSSAGALGFRGSRKSTPFAAQMAAETAAKGSIEHGLKTLEVTVKGPGSGREAAIRAL QAAGLEVTAIRDVTPVPHNGCRPPKRRRV*" /label="rpsK CDS" gene 147950..148345 /gene="rpsK" /locus_tag="BSU_01420" /old_locus_tag="BSU01420" /label="rpsK gene" S_feature 148346..148521 /Source="Nicolas_S_feature" /locus_tag="new_148755_148930" /HighExp="G135, dia5, Lbexp, S0, aero, dia0, T-4.40H, G150, Paraq, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA, SigA, SigA, SigA, SigA, SigWXY, SigA, SigA" /TUlongPSig="1, 1, 0.997, 1, 1, 0.999, 1, 1, 0.947" /label="S56" CDS 148522..149466 /gene="rpoA" /locus_tag="BSU_01430" /old_locus_tag="BSU01430" /EC_number="2.7.7.6" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1484484, 6811591, 9594570, 10972808, 12682299, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1484484, 6811591, 9594570, 10972808, 12682299, 22720735; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="RNA polymerase (alpha subunit)" /protein_id="NP_388024.1" /db_xref="EnsemblGenomes-Gn:BSU01430" /db_xref="EnsemblGenomes-Tr:CAB11919" /db_xref="GOA:P20429" /db_xref="InterPro:IPR011260" /db_xref="InterPro:IPR011262" /db_xref="InterPro:IPR011263" /db_xref="InterPro:IPR011773" /db_xref="InterPro:IPR036603" /db_xref="InterPro:IPR036643" /db_xref="PDB:1Z3E" /db_xref="PDB:3GFK" /db_xref="PDB:3IHQ" /db_xref="SubtiList:BG10732" /db_xref="UniProtKB/Swiss-Prot:P20429" /translation="MIEIEKPKIETVEISDDAKFGKFVVEPLERGYGTTLGNSLRRIL LSSLPGAAVTSIQIDGVLHEFSTIEGVVEDVTTIILHIKKLALKIYSDEEKTLEIDVQ GEGTVTAADITHDSDVEILNPDLHIATLGENASFRVRLTAQRGRGYTPADANKRDDQP IGVIPIDSIYTPVSRVSYQVENTRVGQVANYDKLTLDVWTDGSTGPKEAIALGSKILT EHLNIFVGLTDEAQHAEIMVEKEEDQKEKVLEMTIEELDLSVRSYNCLKRAGINTVQE LANKTEEDMMKVRNLGRKSLEEVKAKLEELGLGLRKDD*" /label="rpoA CDS" gene 148522..149466 /gene="rpoA" /locus_tag="BSU_01430" /old_locus_tag="BSU01430" /label="rpoA gene" CDS 149544..149906 /gene="rplQ" /locus_tag="BSU_01440" /old_locus_tag="BSU01440" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6801428, 10717392, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6801428, 10717392, 12682299; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L17 (BL15)" /protein_id="NP_388025.1" /db_xref="EnsemblGenomes-Gn:BSU01440" /db_xref="EnsemblGenomes-Tr:CAB11920" /db_xref="GOA:P20277" /db_xref="InterPro:IPR000456" /db_xref="InterPro:IPR036373" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11041" /db_xref="UniProtKB/Swiss-Prot:P20277" /translation="MSYRKLGRTSAQRKAMLRDLTTDLIINERIETTETRAKELRSVV EKMITLGKRGDLHARRQAAAYIRNEVANEENNQDALQKLFSDIATRYEERQGGYTRIM KLGPRRGDGAPMAIIELV*" /label="rplQ CDS" gene 149544..149906 /gene="rplQ" /locus_tag="BSU_01440" /old_locus_tag="BSU01440" /label="rplQ gene" downshifts 149908 /Source="Nicolas_upshifts" /id="D52" /incds=0 /nref=171 /ntot=259 /MaxReadThrough="7.50771" /MaxDrop="5.4374" /score="2.32634618" /energy="-10.5" /TU="U98" /idTUdmin="U98" /TUdmin="-5577" /isTUend="FALSE" /label="downshifts" S_feature 149953..150033 /Source="Nicolas_S_feature" /locus_tag="new_150362_150442" /HighExp="Cold, G180, G135, G150, H2O2, S0, C30, Oxctl, Paraq, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA, SigA, SigA, SigA, SigA, SigWXY, SigA, SigA" /TUlongPSig="1, 1, 0.997, 1, 1, 0.999, 1, 1, 0.947" /label="S57" CDS 150034..150879 /gene="ecfA" /locus_tag="BSU_01450" /old_locus_tag="BSU01450" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12110480, 21135102, 26052893; Product type t: transporter" /codon_start=1 /transl_table=11 /product="energizing coupling factor of ABC influx transporter (ATP-binding protein)" /protein_id="NP_388026.2" /db_xref="EnsemblGenomes-Gn:BSU01450" /db_xref="EnsemblGenomes-Tr:CAB11921" /db_xref="GOA:P40735" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR015856" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030947" /db_xref="SubtiList:BG11067" /db_xref="UniProtKB/Swiss-Prot:P40735" /translation="MNQNQLISVEDIVFRYRKDAERRALDGVSLQVYEGEWLAIVGHN GSGKSTLARALNGLILPESGDIEVAGIQLTEESVWEVRKKIGMVFQNPDNQFVGTTVR DDVAFGLENNGVPREEMIERVDWAVKQVNMQDFLDQEPHHLSGGQKQRVAIAGVIAAR PDIIILDEATSMLDPIGREEVLETVRHLKEQGMATVISITHDLNEAAKADRIIVMNGG KKYAEGPPEEIFKLNKELVRIGLDLPFSFQLSQLLRENGLALEENHLTQEGLVKELWT LQSKM*" /label="ecfA CDS" gene 150034..150879 /gene="ecfA" /locus_tag="BSU_01450" /old_locus_tag="BSU01450" /label="ecfA gene" CDS 150894..151724 /gene="ecfAB" /locus_tag="BSU_01460" /old_locus_tag="BSU01460" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12110480, 21135102, 26052893" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12110480, 21135102, 26052893; Product type t: transporter" /codon_start=1 /transl_table=11 /product="energizing coupling factor of ABC influx transporter (ATP-binding protein)" /protein_id="NP_388027.1" /db_xref="EnsemblGenomes-Gn:BSU01460" /db_xref="EnsemblGenomes-Tr:CAB11922" /db_xref="GOA:P70970" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR015856" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030946" /db_xref="SubtiList:BG11989" /db_xref="UniProtKB/Swiss-Prot:P70970" /translation="MKTPFERLALYDINASIKEGSYVAVIGHTGSGKSTLLQHLNGLL KPTKGQISLGSTVIQAGKKNKDLKKLRKKVGIVFQFPEHQLFEETVLKDISFGPMNFG VKKEDAEQKAREMLQLVGLSEELLDRSPFELSGGQMRRVAIAGVLAMDPEVLVLDEPT AGLDPRGRKEIMDMFYELHQRGNLTTILVTHSMEDAAAYADEMIVMHKGTIQASGSPR DLFLKGEEMAGWGLDLPETIKFQRHLEAALGVRFNEPMLTIEDAAAEIRALFQGEKTL *" /label="ecfAB CDS" gene 150894..151724 /gene="ecfAB" /locus_tag="BSU_01460" /old_locus_tag="BSU01460" /label="ecfAB gene" CDS 151721..152518 /gene="ecfT" /locus_tag="BSU_01470" /old_locus_tag="BSU01470" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16850406, 18931129, 21135102, 26052893; Product type t : transporter" /codon_start=1 /transl_table=11 /product="component of the influx ECF transporters" /protein_id="NP_388028.2" /db_xref="EnsemblGenomes-Gn:BSU01470" /db_xref="EnsemblGenomes-Tr:CAB11923" /db_xref="GOA:P70972" /db_xref="InterPro:IPR003339" /db_xref="InterPro:IPR024919" /db_xref="SubtiList:BG11990" /db_xref="UniProtKB/Swiss-Prot:P70972" /translation="MMDSMIIGKYVPGTSLVHRLDPRTKLITIFLFVCIVFLANNVQT YALLGLFTIGVVSLTRVPFSFLMKGLKPIIWIVLFTFLLHILMTHEGPIIFQIGFFKV YEGGLVQGIFISLRFVYLILITTLLTLTTTPIEITDGMEQLLNPLKKLKLPVHELALM MSISLRFIPTLMEETDKIMKAQMARGVDFTSGPVKERVKAIVPLLVPLFVSAFKRAEE LAVAMEARGYQGGEGRTKYRKLVWTGKDTSVIVSLIVLAALLFFLRA*" /label="ecfT CDS" gene 151721..152518 /gene="ecfT" /locus_tag="BSU_01470" /old_locus_tag="BSU01470" /label="ecfT gene" CDS 152528..153271 /gene="truA" /locus_tag="BSU_01480" /old_locus_tag="BSU01480" /EC_number="5.4.99.12" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10529181, 15353568, 17114947, 17466622; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA pseudouridine (38-40) synthase" /protein_id="NP_388029.2" /db_xref="EnsemblGenomes-Gn:BSU01480" /db_xref="EnsemblGenomes-Tr:CAB11924" /db_xref="GOA:P70973" /db_xref="InterPro:IPR001406" /db_xref="InterPro:IPR020095" /db_xref="InterPro:IPR020097" /db_xref="InterPro:IPR020103" /db_xref="SubtiList:BG11992" /db_xref="UniProtKB/Swiss-Prot:P70973" /translation="MRLKCTISYDGHLFNGYQVQPGKRTVQDELEKALAVLHKSKDRI PVVSSGRTDSGVHAAGQVIHFDTPLSIPAERWPYALNALLPDDIAVKQAEIADDGFHA RFSAVKKEYRYFVYTEKHPDVFKRHYAYHFSYRLNVQDMREAAKHLIGTHDFTSFCAA KTEVQDKVRTIYELDWTETADGLQMRITGSGFLYNMVRIIAGTLLDAGIGKISPDEVK SMLEAKDREAAGRTAPGHGLYLWNVYYDN*" /label="truA CDS" gene 152528..153271 /gene="truA" /locus_tag="BSU_01480" /old_locus_tag="BSU01480" /label="truA gene" S_feature complement(152630..153098) /Source="Nicolas_S_feature" /locus_tag="new_153039_153507_c" /HighExp="S6, S8, S7, C30, G135, BT, S5, C90, M/G, Pyr" /AntisenseName="truA" /AntisenseCor="-0.30232258010971202" /AntisenseRegPval="-6.4" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S58" promotor_-35 152763..152768 /Source="Nicolas_upshift_promotors" /id="U100" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.478521478521479" /psig="0.478521478521479" /xcortree=2469 /SigmaFactorBS="cggctgagagatggccatatgCCTTAAatgcactgcttccgG ACGATATCGCAGTCAAAcaggcagaaattgcggatgatgggttccatgcacgatttag c" /listShort="NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 152783..152800 /Source="Nicolas_upshift_promotors" /id="U100" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.478521478521479" /psig="0.478521478521479" /xcortree=2469 /SigmaFactorBS="cggctgagagatggccatatgCCTTAAatgcactgcttccgG ACGATATCGCAGTCAAAcaggcagaaattgcggatgatgggttccatgcacgatttag c" /listShort="NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 152802 /Source="Nicolas_upshifts" /id="U100" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.478521478521479" /psig="0.478521478521479" /xcortree=2469 /SigmaFactorBS="cggctgagagatggccatatgCCTTAAatgcactgcttccgG ACGATATCGCAGTCAAAcaggcagaaattgcggatgatgggttccatgcacgatttag c" /listShort="NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(153098..153117) /Source="Nicolas_upshift_promotors" /id="U101" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1250 /SigmaFactorBS="ttcacctcatcgggagaaatttttccaatacctgcatcaagC AAAGTACCCgcaataattctgACCATATTATATAAGAAACCgctgcctgtgatccgca t" /listShort="S58" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(153120) /Source="Nicolas_upshifts" /id="U101" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1250 /SigmaFactorBS="ttcacctcatcgggagaaatttttccaatacctgcatcaagC AAAGTACCCgcaataattctgACCATATTATATAAGAAACCgctgcctgtgatccgca t" /listShort="S58" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(153130..153139) /Source="Nicolas_upshift_promotors" /id="U101" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1250 /SigmaFactorBS="ttcacctcatcgggagaaatttttccaatacctgcatcaagC AAAGTACCCgcaataattctgACCATATTATATAAGAAACCgctgcctgtgatccgca t" /listShort="S58" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 153291..153297 /Source="Nicolas_upshift_promotors" /id="U102" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2644 /SigmaFactorBS="ttactatgacaactaaaccaggtgtataatattttCTTGACA gagtctgcataaagTTATAAGATATCATATGGTAtgtatttcaaccccacgataagcc c" /listShort="NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 153312..153331 /Source="Nicolas_upshift_promotors" /id="U102" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2644 /SigmaFactorBS="ttactatgacaactaaaccaggtgtataatattttCTTGACA gagtctgcataaagTTATAAGATATCATATGGTAtgtatttcaaccccacgataagcc c" /listShort="NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 153316 /Source="Nicolas_upshifts" /id="U102" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2644 /SigmaFactorBS="ttactatgacaactaaaccaggtgtataatattttCTTGACA gagtctgcataaagTTATAAGATATCATATGGTAtgtatttcaaccccacgataagcc c" /listShort="NA, rplM, rpsI, S59, ybaJ" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 153328..153384 /gene="ldlM" /locus_tag="BSU_misc_RNA_4" /product="putative L13_leader" /note="Evidence 3: Putative function from multiple computational evidences; Product type n: RNA" /label="ldlM RNA" gene 153328..153384 /gene="ldlM" /locus_tag="BSU_misc_RNA_4" /label="ldlM gene" CDS 153433..153870 /gene="rplM" /locus_tag="BSU_01490" /old_locus_tag="BSU01490" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10781545, 12682299, 23504016, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10781545, 12682299, 23504016, 22720735; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L13" /protein_id="NP_388030.2" /db_xref="EnsemblGenomes-Gn:BSU01490" /db_xref="EnsemblGenomes-Tr:CAB11925" /db_xref="GOA:P70974" /db_xref="InterPro:IPR005822" /db_xref="InterPro:IPR005823" /db_xref="InterPro:IPR023563" /db_xref="InterPro:IPR036899" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11970" /db_xref="UniProtKB/Swiss-Prot:P70974" /translation="MRTTPMANASTIERKWLVVDAAGKTLGRLSSEVAAILRGKHKPT YTPHVDTGDHVIIINAEKIELTGKKLTDKIYYRHTQHPGGLKSRTALEMRTNYPEKML ELAIKGMLPKGSLGRQMFKKLNVYRGSEHPHEAQKPEVYELRG*" /label="rplM CDS" gene 153433..153870 /gene="rplM" /locus_tag="BSU_01490" /old_locus_tag="BSU01490" /label="rplM gene" CDS 153891..154283 /gene="rpsI" /locus_tag="BSU_01500" /old_locus_tag="BSU01500" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 19653700, 22720735; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S9" /protein_id="NP_388031.1" /db_xref="EnsemblGenomes-Gn:BSU01500" /db_xref="EnsemblGenomes-Tr:CAB11926" /db_xref="GOA:P21470" /db_xref="InterPro:IPR000754" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR020574" /db_xref="InterPro:IPR023035" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG19007" /db_xref="UniProtKB/Swiss-Prot:P21470" /translation="MAQVQYYGTGRRKSSVARVRLVPGEGRIVVNNREISEHIPSAAL IEDIKQPLTLTETAGTYDVLVNVHGGGLSGQAGAIRHGIARALLEADPEYRTTLKRAG LLTRDARMKERKKYGLKGARRAPQFSKR*" /label="rpsI CDS" gene 153891..154283 /gene="rpsI" /locus_tag="BSU_01500" /old_locus_tag="BSU01500" /label="rpsI gene" downshifts 154258 /Source="Nicolas_upshifts" /id="D53" /incds=0 /nref=262 /ntot=282 /MaxReadThrough="4.65387" /MaxDrop="8.11906" /score="30.5093496" /energy="-13.3" /TU="U98,U100,U102" /idTUdmin="U98" /TUdmin="-1227" /isTUend="FALSE" /label="downshifts" promotor_-35 154400..154407 /Source="Nicolas_upshift_promotors" /id="U103" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.97002997002997" /psig="0.999000999001" /xcortree=2051 /SigmaFactorBS="ctgaatggacgcttgacggggttaagcaaatTGTTTGTTtat aaacggtctcTTTGTAATAATCATGGTAGAtttcattcttattcaattggaagttcgg t" /listShort="S59, ybaJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 154421..154440 /Source="Nicolas_upshift_promotors" /id="U103" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.97002997002997" /psig="0.999000999001" /xcortree=2051 /SigmaFactorBS="ctgaatggacgcttgacggggttaagcaaatTGTTTGTTtat aaacggtctcTTTGTAATAATCATGGTAGAtttcattcttattcaattggaagttcgg t" /listShort="S59, ybaJ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 154429..154710 /Source="Nicolas_S_feature" /locus_tag="new_154838_155119" /HighExp="H2O2, G180, G135, Paraq, Diami, dia15, Oxctl, Cold, Heat, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, Sig-, SigA" /TUshortPSig="0.999, 1, 0.479, 1" /TUlongSig="SigA, SigA, SigA, SigA, SigA, SigA, SigWXY, SigA, SigA" /TUlongPSig="1, 1, 0.997, 1, 1, 0.999, 1, 1, 0.947" /label="S59" upshifts 154429 /Source="Nicolas_upshifts" /id="U103" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.97002997002997" /psig="0.999000999001" /xcortree=2051 /SigmaFactorBS="ctgaatggacgcttgacggggttaagcaaatTGTTTGTTtat aaacggtctcTTTGTAATAATCATGGTAGAtttcattcttattcaattggaagttcgg t" /listShort="S59, ybaJ" /GFF_Attribute="listLong" /label="upshifts" misc_feature 154709..154728 /Source="Nicolas_upshift_promotors" /id="U104" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.625374625374625" /psig="0.804195804195804" /xcortree=3216 /SigmaFactorBS="gtttttatgaacttttttctaaatatgcaaagggaaagcgat atcaatctagaaataTTTGTTATACTCTATACATTaaagtaaggagaagattcatgaa t" /listShort="ybaJ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 154712 /Source="Nicolas_upshifts" /id="U104" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.625374625374625" /psig="0.804195804195804" /xcortree=3216 /SigmaFactorBS="gtttttatgaacttttttctaaatatgcaaagggaaagcgat atcaatctagaaataTTTGTTATACTCTATACATTaaagtaaggagaagattcatgaa t" /listShort="ybaJ" /GFF_Attribute="listLong" /label="upshifts" CDS 154747..155514 /gene="ybaJ" /locus_tag="BSU_01510" /old_locus_tag="BSU01510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 26582911; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative methyltransferase" /protein_id="NP_388032.2" /db_xref="EnsemblGenomes-Gn:BSU01510" /db_xref="EnsemblGenomes-Tr:CAB11927" /db_xref="GOA:P70976" /db_xref="InterPro:IPR013216" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11994" /db_xref="UniProtKB/Swiss-Prot:P70976" /translation="MNALVAHNSKAWDKKVETGNEWTVAVEQQVIEQAKKGNWDIRVT PMKDVPKDWFPPIKGLKVLCLASGGGQQGPVLAAAGADVTVLDNSEKQLNQDRMIAER DGLTIHTVKGSMDDLSVFNDESFDVIVHPVANVFVENVLPVWKEAYRVLKRNGILISG FVNPVVFLFDTELEQQGVLKVKHSIPYADPEDLPKHKVKKLIENNEALEFGHSLEDQI KGQIDAGFIVTGFYEDKGGFVLDQYIHTYSATRSVKV*" /label="ybaJ CDS" gene 154747..155514 /gene="ybaJ" /locus_tag="BSU_01510" /old_locus_tag="BSU01510" /label="ybaJ gene" downshifts 155505 /Source="Nicolas_upshifts" /id="D54" /incds=0 /nref=215 /ntot=251 /MaxReadThrough="2.69346" /MaxDrop="6.09641" /score="4.42269359" /energy="-10.3" /TU="NA" /idTUdmin="U100" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-35 155644..155650 /Source="Nicolas_upshift_promotors" /id="U105" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=864 /SigmaFactorBS="ccttcatttgggcgaatttccaaccgaattcgGGCATTGttt catcatccaaaCCTCAAAATAATcggtaaaaggagagtgaatttatatggcagaagta c" /listShort="ybaK, cwlD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 155665..155676 /Source="Nicolas_upshift_promotors" /id="U105" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=864 /SigmaFactorBS="ccttcatttgggcgaatttccaaccgaattcgGGCATTGttt catcatccaaaCCTCAAAATAATcggtaaaaggagagtgaatttatatggcagaagta c" /listShort="ybaK, cwlD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 155672 /Source="Nicolas_upshifts" /id="U105" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=864 /SigmaFactorBS="ccttcatttgggcgaatttccaaccgaattcgGGCATTGttt catcatccaaaCCTCAAAATAATcggtaaaaggagagtgaatttatatggcagaagta c" /listShort="ybaK, cwlD" /GFF_Attribute="listLong" /label="upshifts" CDS 155700..156143 /gene="ybaK" /locus_tag="BSU_01520" /old_locus_tag="BSU01520" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 14679227, 16267290" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388033.1" /db_xref="EnsemblGenomes-Gn:BSU01520" /db_xref="EnsemblGenomes-Tr:CAB11928" /db_xref="GOA:P50862" /db_xref="InterPro:IPR019667" /db_xref="SubtiList:BG11503" /db_xref="UniProtKB/Swiss-Prot:P50862" /translation="MAEVLSFMDVKRQKDFELEKNLLKELSLRQIIQSVKDCLEPLFP FLHDERDIITEGCIDFAIEAYLLGGRFGIFGYYGESMQSISARSAREEEELRMEFFDY LYNWIHEQYATFDKNTVYEAARKFIKDWWTAGFVQREKQCKLRMR*" /label="ybaK CDS" gene 155700..156143 /gene="ybaK" /locus_tag="BSU_01520" /old_locus_tag="BSU01520" /label="ybaK gene" promotor_-35 156143..156148 /Source="Nicolas_upshift_promotors" /id="U106" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=973 /SigmaFactorBS="gttcaaagagaaaaacagtgtaagcttcgcatgcggtaATCA TAtttcccgaccctgtcCCATAGTTATGTAATAACGgacaagcgggaggggaagggat g" /listShort="cwlD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 156164..156182 /Source="Nicolas_upshift_promotors" /id="U106" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=973 /SigmaFactorBS="gttcaaagagaaaaacagtgtaagcttcgcatgcggtaATCA TAtttcccgaccctgtcCCATAGTTATGTAATAACGgacaagcgggaggggaagggat g" /listShort="cwlD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 156165 /Source="Nicolas_upshifts" /id="U106" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=973 /SigmaFactorBS="gttcaaagagaaaaacagtgtaagcttcgcatgcggtaATCA TAtttcccgaccctgtcCCATAGTTATGTAATAACGgacaagcgggaggggaagggat g" /listShort="cwlD" /GFF_Attribute="listLong" /label="upshifts" CDS 156203..156916 /gene="cwlD" /locus_tag="BSU_01530" /old_locus_tag="BSU01530" /EC_number="3.5.1.28" /function="16.13: Shape" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:14679227, 16267290" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14679227, 16267290; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylmuramoyl-L-alanine amidase" /protein_id="NP_388034.1" /db_xref="EnsemblGenomes-Gn:BSU01530" /db_xref="EnsemblGenomes-Tr:CAB11929" /db_xref="GOA:P50864" /db_xref="InterPro:IPR002508" /db_xref="InterPro:IPR014234" /db_xref="SubtiList:BG11514" /db_xref="UniProtKB/Swiss-Prot:P50864" /translation="MRKKLKWLSFLLGFIILLFLFKYQFSNNDSWKPWSLPLSGKIIY LDPGHGGPDGGAVGGKLLEKDVTLEVAFRVRDYLQEQGALVIMTRESDTDLAPEGTKG YSRRKAEDLRQRVKLINHSEAELYISIHLNAIPSQKWSGAQSFYYGKYAENEKVAKYI QDELRRNLENTTRKAKRIHGIYLMQNVTKPGALIEVGFLSNPSEATLLGKPKYQDKVA SSIYKGILRYFTEKGDPPE*" /label="cwlD CDS" gene 156203..156916 /gene="cwlD" /locus_tag="BSU_01530" /old_locus_tag="BSU01530" /label="cwlD gene" upshifts 156961 /Source="Nicolas_upshifts" /id="U107" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.965034965034965" /psig="0.998001998001998" /xcortree=3187 /SigmaFactorBS="agaccctccggagtaatggagggttttcttgtggttctaagc ataagacacccgccatttatgTATGATATAATAATAATTGTaaacgaatacacaaaag g" /listShort="salA, S61, kbaA, S63, S64, rrnI-16S" /GFF_Attribute="listLong" /label="upshifts" misc_feature 156964..156983 /Source="Nicolas_upshift_promotors" /id="U107" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.965034965034965" /psig="0.998001998001998" /xcortree=3187 /SigmaFactorBS="agaccctccggagtaatggagggttttcttgtggttctaagc ataagacacccgccatttatgTATGATATAATAATAATTGTaaacgaatacacaaaag g" /listShort="salA, S61, kbaA, S63, S64, rrnI-16S" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 157012..158070 /gene="salA" /locus_tag="BSU_01540" /old_locus_tag="BSU01540" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11790741, 15126467, 26094643" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11790741, 15126467, 26094643; Product type r: regulator" /codon_start=1 /transl_table=11 /product="phosphorylation-dependent (Y327) transcriptionalregulator" /protein_id="NP_388035.1" /db_xref="EnsemblGenomes-Gn:BSU01540" /db_xref="EnsemblGenomes-Tr:CAB11930" /db_xref="GOA:P50863" /db_xref="InterPro:IPR000808" /db_xref="InterPro:IPR019591" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR033756" /db_xref="InterPro:IPR034904" /db_xref="SubtiList:BG11494" /db_xref="UniProtKB/Swiss-Prot:P50863" /translation="MIREDEVRKLVGEMREPFLQRPLGELDAVKEIKIKPEKRHISVK VALAKTGTAEQMQIQQEIVNVLKGAGAETVGLRFEELPEETVAKFRAPSAEKKTLLNM DNPPVFLAVASGKGGVGKSTVSVNLAISLARLGKKVGLIDADIYGFSVPDMMGITVRP TIEGEKLLPVERFGVKVMSMGFFVEENAPVVWRGPMLGKMLNNFFHEVEWGEVDYIVL DLPPGTGDVALDVHTMLPSCKEIIVSTPHPTAAFVAARAGSMAIKTDHEVVGVIENMA YYESAKTGEREYVFGKGGGDKLAEELNVPLLGRIPLKQPDWDKDQFAPSVYDENHPIG EIYQDIAKKIDAKMSVQV*" /label="salA CDS" gene 157012..158070 /gene="salA" /locus_tag="BSU_01540" /old_locus_tag="BSU01540" /label="salA gene" S_feature complement(157641..158105) /Source="Nicolas_S_feature" /locus_tag="new_158050_158514_c" /HighExp="S8, S7, S6, S5, C30, S4, C90, nit, ferm, Gly" /AntisenseName="salA" /AntisenseCor="-0.104183954485248" /AntisenseRegPval="-1.1000000000000001" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S60" downshifts 158056 /Source="Nicolas_upshifts" /id="D55" /incds=0 /nref=29 /ntot=155 /MaxReadThrough="5.44939" /MaxDrop="4.18382" /score="-4.46878413" /energy="-9.1" /TU="U107" /idTUdmin="U106" /TUdmin=1185 /isTUend="FALSE" /label="downshifts" S_feature 158101..158772 /Source="Nicolas_S_feature" /locus_tag="new_158510_159181" /HighExp="Lbtran, H2O2, Cold, Lbstat, dia5, M40t45, M0t90, M40t90, T0.30H, S1" /AntisenseName="gerD" /AntisenseCor="-0.24235509346425901" /AntisenseRegPval="-4.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S61" CDS complement(158106..158663) /gene="gerD" /locus_tag="BSU_01550" /old_locus_tag="BSU01550" /function="16.13: Shape" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17122337, 10618233, 10376819, 24530795" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17122337, 10618233, 10376819, 24530795; Product type f: factor" /codon_start=1 /transl_table=11 /product="lipoprotein factor mediating clustering of germination proteins" /protein_id="NP_388036.1" /db_xref="EnsemblGenomes-Gn:BSU01550" /db_xref="EnsemblGenomes-Tr:CAB11931" /db_xref="GOA:P16450" /db_xref="SubtiList:BG10644" /db_xref="UniProtKB/Swiss-Prot:P16450" /translation="MSKAKTLLMSCFLLLSVTACAPKDQAADMDYDQTKKMVVDILKT DDGKKAIKELLNDDAMNEALVIDQDAIKGTIEKTLTSKKGEEFWKNIFEDTDFAEGFA KTLQTEHEKVIKKLMKDPDYQKMLMSVMQDPGMDKKYSQLAKSQEFRSYLEEVINETL SSPLYKKQFEDELKKAAKDTAKESE*" /label="gerD CDS" gene complement(158106..158663) /gene="gerD" /locus_tag="BSU_01550" /old_locus_tag="BSU01550" /label="gerD gene" promotor_-10 complement(158695..158706) /Source="Nicolas_upshift_promotors" /id="U108" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=925 /SigmaFactorBS="tattcatcccctcaaaaatcgcgaacagcgatattttgttaT GTATAAttccaaacagatgAATCATATTAAAggtaagacaagtatgtgaaaggagctt a" /listShort="gerD, S60" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(158707) /Source="Nicolas_upshifts" /id="U108" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=925 /SigmaFactorBS="tattcatcccctcaaaaatcgcgaacagcgatattttgttaT GTATAAttccaaacagatgAATCATATTAAAggtaagacaagtatgtgaaaggagctt a" /listShort="gerD, S60" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(158720..158726) /Source="Nicolas_upshift_promotors" /id="U108" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=925 /SigmaFactorBS="tattcatcccctcaaaaatcgcgaacagcgatattttgttaT GTATAAttccaaacagatgAATCATATTAAAggtaagacaagtatgtgaaaggagctt a" /listShort="gerD, S60" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(158740..159369) /Source="Nicolas_S_feature" /locus_tag="new_159149_159778_c" /HighExp="S3, T5.0H, S4, S8, M9-stat, T4.0H, T3.30H, S7, T3.0H, S6" /AntisenseName="kbaA" /AntisenseCor="7.9344921760152495E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S62" CDS 158773..159369 /gene="kbaA" /locus_tag="BSU_01560" /old_locus_tag="BSU01560" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8576055, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8576055, 15849754, 16850406; Product type r: regulator" /codon_start=1 /transl_table=11 /product="inner membrane protein involved in activation ofthe KinB signaling pathway to sporulation" /protein_id="NP_388037.1" /db_xref="EnsemblGenomes-Gn:BSU01560" /db_xref="EnsemblGenomes-Tr:CAB11932" /db_xref="GOA:P16449" /db_xref="InterPro:IPR024164" /db_xref="SubtiList:BG10643" /db_xref="UniProtKB/Swiss-Prot:P16449" /translation="MKSRGLVRFFFSILAVGALITSIVGFALKWGEYRGLFLTFEAGQ IFSVLFWFIGVGMIFSVISQMGFFVFLTVHRFALEILRSSSLWNLLQLFFILFVAFDL MYVRFLFFGESGESLAGYAWLPVFLLIFGVITAYIKQKQSSKKTFVSSLFLMVVITAL EWFPALRVNDEDWLYLMLFPLMACNAFQLLMLPKFAAK*" /label="kbaA CDS" gene 158773..159369 /gene="kbaA" /locus_tag="BSU_01560" /old_locus_tag="BSU01560" /label="kbaA gene" S_feature 159370..160264 /Source="Nicolas_S_feature" /locus_tag="new_159779_160673" /HighExp="Lbstat, Lbtran, M0t90, M40t90, H2O2, BC, Glucon, S7, M40t45, S1" /AntisenseName="ybaN" /AntisenseCor="-2.6735901031407501E-2" /AntisenseRegPval="-0.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S63" CDS complement(159370..160134) /gene="pdaB" /locus_tag="BSU_01570" /old_locus_tag="BSU01570" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12662922, 15547282, 15598884" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12662922, 15547282, 15598884; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="polysaccharide deacetylase involved in sporulation" /protein_id="NP_388038.1" /db_xref="EnsemblGenomes-Gn:BSU01570" /db_xref="EnsemblGenomes-Tr:CAB11933" /db_xref="GOA:P50865" /db_xref="InterPro:IPR002509" /db_xref="InterPro:IPR011330" /db_xref="InterPro:IPR014132" /db_xref="SubtiList:BG11416" /db_xref="UniProtKB/Swiss-Prot:P50865" /translation="MNHFYVWHIKRVKQLIIILIAAFAAASFFYIQRAVPLPVFSTDT GPKAIYKGETDSKDISLTFDISWGDERAEPILNTLKANGIKNATFFLSASWAERHPDT VARIVKDGHQIGSMGYAYKNYANLESSEIKKDMNRAQTAFEKLGVKDIQLLRPPTGQF NKNVLKVAKQYNYTVVHYSVNSQDWTNPGVEKIIDNVTKQVSGGDIILLHASDSAKQT EEALPDIIHQLKEKGLKNVTVGDLIANSDAKSAEVK*" /label="pdaB CDS" gene complement(159370..160134) /gene="pdaB" /locus_tag="BSU_01570" /old_locus_tag="BSU01570" /label="pdaB gene" promotor_-10 complement(160165..160183) /Source="Nicolas_upshift_promotors" /id="U109" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=979 /SigmaFactorBS="caacacccaatttaggctgtatgtgaagagacattttatcgG TTATAttcaattgtccatgcTCATAAGATGTAAAACAAGaatgatggacaagataagg a" /listShort="ybaN, S62" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(160185) /Source="Nicolas_upshifts" /id="U109" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=979 /SigmaFactorBS="caacacccaatttaggctgtatgtgaagagacattttatcgG TTATAttcaattgtccatgcTCATAAGATGTAAAACAAGaatgatggacaagataagg a" /listShort="ybaN, S62" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(160199..160204) /Source="Nicolas_upshift_promotors" /id="U109" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=979 /SigmaFactorBS="caacacccaatttaggctgtatgtgaagagacattttatcgG TTATAttcaattgtccatgcTCATAAGATGTAAAACAAGaatgatggacaagataagg a" /listShort="ybaN, S62" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 160242..160249 /Source="Nicolas_upshift_promotors" /id="U110" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp=1 /psig=1 /xcortree=2624 /SigmaFactorBS="gataaaatgtctcttcacatacagcctaaattgggtGTTGAC CTtttgataatatccgTGATATATTATTATTCGTCGctgataaacagctgacatcaac t" /listShort="S64, rrnI-16S, rrnI-23S, rrnI-5S, trnI-Asn, trnI-Thr, trnI-Gly, trnI-Arg, trnI-Pro, trnI-Ala, rrnH-16S, rrnH-23S, rrnH-5S, rrnG-16S" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 160264..160283 /Source="Nicolas_upshift_promotors" /id="U110" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp=1 /psig=1 /xcortree=2624 /SigmaFactorBS="gataaaatgtctcttcacatacagcctaaattgggtGTTGAC CTtttgataatatccgTGATATATTATTATTCGTCGctgataaacagctgacatcaac t" /listShort="S64, rrnI-16S, rrnI-23S, rrnI-5S, trnI-Asn, trnI-Thr, trnI-Gly, trnI-Arg, trnI-Pro, trnI-Ala, rrnH-16S, rrnH-23S, rrnH-5S, rrnG-16S" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 160266..160483 /Source="Nicolas_S_feature" /locus_tag="new_160675_160892" /HighExp="Diami, LBGstat, UNK1, H2O2, MG 15, Oxctl, MG-0.1, BMM, T-1.10H, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S64" upshifts 160266 /Source="Nicolas_upshifts" /id="U110" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp=1 /psig=1 /xcortree=2624 /SigmaFactorBS="gataaaatgtctcttcacatacagcctaaattgggtGTTGAC CTtttgataatatccgTGATATATTATTATTCGTCGctgataaacagctgacatcaac t" /listShort="S64, rrnI-16S, rrnI-23S, rrnI-5S, trnI-Asn, trnI-Thr, trnI-Gly, trnI-Arg, trnI-Pro, trnI-Ala, rrnH-16S, rrnH-23S, rrnH-5S, rrnG-16S" /GFF_Attribute="listLong" /label="upshifts" rRNA 160484..162037 /gene="rrnI-16S" /locus_tag="BSU_rRNA_23" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnI-16S rRNA" gene 160484..162037 /gene="rrnI-16S" /locus_tag="BSU_rRNA_23" /modified_by="User" /label="rrnI-16S gene" Polymorphism join(160830,160832) /Source="geneious" /ID="SNP_BsDelta6_161240_161239" /Polymorphism_Type="Insertion" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=0 /Amino_Acid_Change /CDS_Position /Change="C" /Codon_Change /Coverage=45 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides /Variant_Nucleotides="C" /Variant_P_Value="4.2e-57" /Variant_Raw_Frequency=41 /comment="rrnI-16S rRNA" /modified_by="User" / /label="Polymorphism_Delta6" rRNA 162202..165129 /gene="rrnI-23S" /locus_tag="BSU_rRNA_14" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnI-23S rRNA" gene 162202..165129 /gene="rrnI-23S" /locus_tag="BSU_rRNA_14" /label="rrnI-23S gene" rRNA 165185..165301 /gene="rrnI-5S" /locus_tag="BSU_rRNA_15" /product="ribosomal RNA-5S" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnI-5S rRNA" gene 165185..165301 /gene="rrnI-5S" /locus_tag="BSU_rRNA_15" /label="rrnI-5S gene" Polymorphism join(165341,165342) /Source="geneious" /ID="SNP_BsDelta6_165748_165749" /Polymorphism_Type="Deletion" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=2 /Amino_Acid_Change /CDS_Position /Change="-TC" /Codon_Change /Coverage="172 -> 174" /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides="TC" /Variant_Nucleotides /Variant_P_Value="1.5e-307" /Variant_Raw_Frequency=152 /comment="BSU_tRNA_23_Asn" /modified_by="User" / /label="Polymorphism_Delta6" Polymorphism join(165342,165344) /Source="geneious" /ID="SNP_BsDelta6_165751_165751" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change /CDS_Position /Change="C -> T" /Codon_Change /Coverage=172 /locus_tag /Protein_Effect /Reference_Frequency="1.2%" /Reference_Nucleotides="C" /Variant_Nucleotides="T" /Variant_P_Value=0 /Variant_Raw_Frequency=168 /comment="BSU_tRNA_23_Asn" /modified_by="User" / /label="Polymorphism_Delta6" tRNA 165346..165417 /gene="trnI-Asn" /locus_tag="BSU_tRNA_23" /product="tRNA-Asn" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Asn(GUU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnI-Asn tRNA" gene 165346..165417 /gene="trnI-Asn" /locus_tag="BSU_tRNA_23" /label="trnI-Asn gene" Polymorphism join(165417,165419) /Source="geneious" /ID="SNP_BsDelta6_165826_165825" /Polymorphism_Type="Insertion" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=0 /Amino_Acid_Change /CDS_Position /Change="C" /Codon_Change /Coverage=163 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides /Variant_Nucleotides="C" /Variant_P_Value=0 /Variant_Raw_Frequency=160 /comment="BSU_tRNA_23_Asn" /modified_by="User" / /label="Polymorphism_Delta6" tRNA 165423..165495 /gene="trnI-Thr" /locus_tag="BSU_tRNA_24" /product="tRNA-Thr" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Thr(GGU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnI-Thr tRNA" gene 165423..165495 /gene="trnI-Thr" /locus_tag="BSU_tRNA_24" /label="trnI-Thr gene" tRNA 165552..165626 /gene="trnI-Gly" /locus_tag="BSU_tRNA_25" /product="tRNA-Gly" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Gly(GCC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnI-Gly tRNA" gene 165552..165626 /gene="trnI-Gly" /locus_tag="BSU_tRNA_25" /label="trnI-Gly gene" Polymorphism join(165630,165632) /Source="geneious" /ID="SNP_BsDelta6_166038_166037" /Polymorphism_Type="Insertion" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=0 /Amino_Acid_Change /CDS_Position /Change="T" /Codon_Change /Coverage=154 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides /Variant_Nucleotides="T" /Variant_P_Value=0 /Variant_Raw_Frequency=148 /comment="-" /modified_by="User" / /label="Polymorphism_Delta6" tRNA 165658..165734 /gene="trnI-Arg" /locus_tag="BSU_tRNA_26" /product="tRNA-Arg" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Arg(AGC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnI-Arg tRNA" gene 165658..165734 /gene="trnI-Arg" /locus_tag="BSU_tRNA_26" /label="trnI-Arg gene" tRNA 165762..165838 /gene="trnI-Pro" /locus_tag="BSU_tRNA_27" /product="tRNA-Pro" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnI-Pro tRNA" gene 165762..165838 /gene="trnI-Pro" /locus_tag="BSU_tRNA_27" /label="trnI-Pro gene" tRNA 165847..165922 /gene="trnI-Ala" /locus_tag="BSU_tRNA_28" /product="tRNA-Ala" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ala(UGC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnI-Ala tRNA" gene 165847..165922 /gene="trnI-Ala" /locus_tag="BSU_tRNA_28" /label="trnI-Ala gene" Polymorphism join(165937,165938) /Source="geneious" /ID="SNP_BsDelta6_166344_166344" /Polymorphism_Type="Deletion" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change /CDS_Position /Change="-G" /Codon_Change /Coverage=132 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides="G" /Variant_Nucleotides /Variant_P_Value="4.9e-75" /Variant_Raw_Frequency=130 /comment="-" /modified_by="User" / /label="Polymorphism_Delta6" rRNA 166093..167646 /gene="rrnH-16S" /locus_tag="BSU_rRNA_16" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnH-16S rRNA" gene 166093..167646 /gene="rrnH-16S" /locus_tag="BSU_rRNA_16" /label="rrnH-16S gene" rRNA 167811..170738 /gene="rrnH-23S" /locus_tag="BSU_rRNA_29" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnH-23S rRNA" gene 167811..170738 /gene="rrnH-23S" /locus_tag="BSU_rRNA_29" /label="rrnH-23S gene" rRNA 170794..170911 /gene="rrnH-5S" /locus_tag="BSU_rRNA_24" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnH-5S rRNA" gene 170794..170911 /gene="rrnH-5S" /locus_tag="BSU_rRNA_24" /label="rrnH-5S gene" rRNA 171095..172648 /gene="rrnG-16S" /locus_tag="BSU_rRNA_25" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnG-16S rRNA" gene 171095..172648 /gene="rrnG-16S" /locus_tag="BSU_rRNA_25" /label="rrnG-16S gene" rRNA 172813..175740 /gene="rrnG-23S" /locus_tag="BSU_rRNA_27" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnG-23S rRNA" gene 172813..175740 /gene="rrnG-23S" /locus_tag="BSU_rRNA_27" /label="rrnG-23S gene" rRNA 175796..175914 /gene="rrnG-5S" /locus_tag="BSU_rRNA_28" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnG-5S rRNA" gene 175796..175914 /gene="rrnG-5S" /locus_tag="BSU_rRNA_28" /label="rrnG-5S gene" S_feature 175915..176523 /Source="Nicolas_S_feature" /locus_tag="new_176316_176924" /HighExp="G180, G135, C30, Oxctl, Paraq, Cold, G150, H2O2, Heat, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S65" promotor_-35 176491..176495 /Source="Nicolas_upshift_promotors" /id="U111" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.95104895104895" /psig=1 /xcortree=2510 /SigmaFactorBS="tgagccatttttttcttcagcaatcaTCTTGcgtaattgata aaaaTTTATTATGATACTCTTTGTatgacaactccttgcctcaatacaatatactcaa c" /listShort="S66, ybaR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 176511..176530 /Source="Nicolas_upshift_promotors" /id="U111" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.95104895104895" /psig=1 /xcortree=2510 /SigmaFactorBS="tgagccatttttttcttcagcaatcaTCTTGcgtaattgata aaaaTTTATTATGATACTCTTTGTatgacaactccttgcctcaatacaatatactcaa c" /listShort="S66, ybaR" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 176525..176681 /Source="Nicolas_S_feature" /locus_tag="new_176926_177082" /HighExp="LBGstat, G180, G135, dia15, C30, Oxctl, LPhT, G150, Heat, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S66" upshifts 176525 /Source="Nicolas_upshifts" /id="U111" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.95104895104895" /psig=1 /xcortree=2510 /SigmaFactorBS="tgagccatttttttcttcagcaatcaTCTTGcgtaattgata aaaaTTTATTATGATACTCTTTGTatgacaactccttgcctcaatacaatatactcaa c" /listShort="S66, ybaR" /GFF_Attribute="listLong" /label="upshifts" CDS 176682..178118 /gene="ybaR" /locus_tag="BSU_01580" /old_locus_tag="BSU01580" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388039.1" /db_xref="EnsemblGenomes-Gn:BSU01580" /db_xref="EnsemblGenomes-Tr:CAB11934" /db_xref="GOA:P55189" /db_xref="InterPro:IPR001902" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR011547" /db_xref="InterPro:IPR018045" /db_xref="InterPro:IPR036513" /db_xref="SubtiList:BG11562" /db_xref="UniProtKB/Swiss-Prot:P55189" /translation="MNNSFTLKQQWFGNIRKDILAGILVALALIPEAIGFSIIAGVDP MVGLYASFCIAIIISIFGGRPGMISAATGSMAVVMVSLVADHGLQYLFAATILTGIIQ VILGISKIARLMKFIPRSVMIGFVNALAILIFSAQLPQFEGASWSMYAMLAGSLVIIY VLPRFTTAVPSPLVAIIVMTIIAVTFHVDVRTVGDMGNISSSLPHFLIPDVPFTFETL QIIFPYSIALAFVGLLESLLTAQIIDEMTDTDSDKNKESRGQGIANIVTGFFGGMAGC AMIGQSVINTKAGGRGRLSAFVAGAFLMFLIAVLSHVVVKIPMAALVAVMVMVSVGTF DWSSLKGLKKAPLTDSIVMVVTVVTVVVTDDLSKGVFVGVLLSAVFFVAKISKLKIVS HAEDQKLRTYQVKGQIFFASVTDLTNAFIYQEDIERVVIDLTEAHVWDDSGAAALDKI VAKFKEQGIEAELKGLNKASKSLMKQMA*" /label="ybaR CDS" gene 176682..178118 /gene="ybaR" /locus_tag="BSU_01580" /old_locus_tag="BSU01580" /label="ybaR gene" downshifts 178107 /Source="Nicolas_upshifts" /id="D56" /incds=0 /nref=144 /ntot=228 /MaxReadThrough="2.81758" /MaxDrop="4.71162" /score="18.4600501" /energy="-12" /TU="NA" /idTUdmin="U111" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-35 178161..178166 /Source="Nicolas_upshift_promotors" /id="U112" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.653346653346653" /psig="0.707292707292707" /xcortree=1448 /SigmaFactorBS="aatgagatctgggcttttttatatAACATAcacttaagcagc ATTGATATAATAGAGAGAAGagaaattttaaataggggacttgcatatgatgcttcag a" /listShort="ybaS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 178179..178198 /Source="Nicolas_upshift_promotors" /id="U112" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.653346653346653" /psig="0.707292707292707" /xcortree=1448 /SigmaFactorBS="aatgagatctgggcttttttatatAACATAcacttaagcagc ATTGATATAATAGAGAGAAGagaaattttaaataggggacttgcatatgatgcttcag a" /listShort="ybaS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 178197 /Source="Nicolas_upshifts" /id="U112" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.653346653346653" /psig="0.707292707292707" /xcortree=1448 /SigmaFactorBS="aatgagatctgggcttttttatatAACATAcacttaagcagc ATTGATATAATAGAGAGAAGagaaattttaaataggggacttgcatatgatgcttcag a" /listShort="ybaS" /GFF_Attribute="listLong" /label="upshifts" CDS 178264..179184 /gene="ybaS" /locus_tag="BSU_01590" /old_locus_tag="BSU01590" /function="7: Transport and binding proteins" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative sodium dependent transporter" /protein_id="NP_388040.2" /db_xref="EnsemblGenomes-Gn:BSU01590" /db_xref="EnsemblGenomes-Tr:CAB11935" /db_xref="GOA:P55190" /db_xref="InterPro:IPR002657" /db_xref="InterPro:IPR004710" /db_xref="SubtiList:BG11563" /db_xref="UniProtKB/Swiss-Prot:P55190" /translation="MPLLTPTSVVLGVLLSQFLNGYEWAVPWIFAFITFAGSLSANFQ SLRHALSHPLPMILALFVLHIFMPLFAWGSGHLIFKGDPLTITGLTLAVVIPTGITSL IWAAMYKGNVGLTLSIILVDTVLSPLIVPLSLSLLAGAQVHMDVWGMMKGLIVMVVIP SFLGMLFNQMSSPERTAFVSSALSPFSKLCLMAVIAINSSAIAPYFKSIDLRFAGIAV TVFFIALTGYAAAWLIGKMMKRRQEEIVSLIFTGGMRNISAGAVLAVTFFPSQVAVPV VIGMLFQQILAALFGYMLNRFELKPMLQKA*" /label="ybaS CDS" gene 178264..179184 /gene="ybaS" /locus_tag="BSU_01590" /old_locus_tag="BSU01590" /label="ybaS gene" downshifts 179165 /Source="Nicolas_upshifts" /id="D57" /incds=0 /nref=33 /ntot=224 /MaxReadThrough="1.3063" /MaxDrop="3.58628" /score="13.3102824" /energy="-10.5" /TU="NA" /idTUdmin="U112" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(179194..179946) /gene="eesA" /locus_tag="BSU_01600" /old_locus_tag="BSU01600" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 2974033, 17725565, 22210890, 28283524" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 2974033, 17725565, 22210890, 28283524; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="iron-chelator (enterobactin family) esterase" /protein_id="NP_388041.2" /db_xref="EnsemblGenomes-Gn:BSU01600" /db_xref="EnsemblGenomes-Tr:CAB11936" /db_xref="GOA:P55192" /db_xref="InterPro:IPR000801" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG11565" /db_xref="UniProtKB/Swiss-Prot:P55192" /translation="MKGSLSEHKAGNRRFTLYLPPSYSTDSGGFPAVYVQDGSSLFQN QIELLESAFQQQRLPELVLIGIEPENRLDEYTPWPAASLSDRFTDFGGMGYHYLSDIT NQFIPLIEENWNVTREPQSRGMIGASLGGLISMFAILKYPSMFGKIGSISGSYWYENA AETIHISSLKPGTARVFMSIGSEEGREKQSIQRHMLKKTKQVHQSLKEKGFTEDQLCL SIEKGAVHHHKYFCKQFINALEWLYGKNRSTL*" /label="eesA CDS" gene complement(179194..179946) /gene="eesA" /locus_tag="BSU_01600" /old_locus_tag="BSU01600" /label="eesA gene" downshifts complement(179218) /Source="Nicolas_upshifts" /id="D58" /incds=0 /nref=15 /ntot=115 /MaxReadThrough="0.3819" /MaxDrop="4.57603" /score="25.9728338" /energy="-10.5" /TU="NA" /idTUdmin="U114" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(179943..180953) /gene="feuC" /locus_tag="BSU_01610" /old_locus_tag="BSU01610" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 2651410, 15849754, 16850406, 27375568; Product type t: transporter" /codon_start=1 /transl_table=11 /product="iron-uptake protein" /protein_id="NP_388042.2" /db_xref="EnsemblGenomes-Gn:BSU01610" /db_xref="EnsemblGenomes-Tr:CAB11937" /db_xref="GOA:P40411" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG10837" /db_xref="UniProtKB/Swiss-Prot:P40411" /translation="MAKKYALFIALILVVSYFSLTSGSFSVRPAELLSTLFQIDPNPQ YEILLFDLRLPRVVMAAIIGLGLGIAGAVIQAITRNGLADPGILGINAGAGAGIVAFM LLFQGQKEVTSIAAAMGMPLFGLIGGLIAAILIYIFAWHRGNLDSGRIILVGIAINSG FSALSLFLSLKMDPQDYQMAMVWKNGSIWSANWTYITAVLPWMLLFIPILIGKSRLLD TIRFDEDTVRSLGISSNKEKTILLVACVAIISACVSVAGSMAFVGLIAPHISRRLAGV EHRYILPLSGLIGMLLVISADFAGKLFFQPAEVPAGIILAILGVPYFLYLLFKQKKGE NA*" /label="feuC CDS" gene complement(179943..180953) /gene="feuC" /locus_tag="BSU_01610" /old_locus_tag="BSU01610" /label="feuC gene" CDS complement(180946..181950) /gene="feuB" /locus_tag="BSU_01620" /old_locus_tag="BSU01620" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2651410, 15849754, 16850406, 17725565; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ferri-bacillibactin permease" /protein_id="NP_388043.1" /db_xref="EnsemblGenomes-Gn:BSU01620" /db_xref="EnsemblGenomes-Tr:CAB11938" /db_xref="GOA:P40410" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG10836" /db_xref="UniProtKB/Swiss-Prot:P40410" /translation="MYSKQWTRIILITSPFAIALSLLLSILYGAKHLSTDIVFTSLIH FDPGNTDHQIIWHSRIPRAAGALLIGAALAVSGALMQGITRNYLASPSIMGVSDGSAF IITLCMVLLPQSSSIEMMIYSFIGSALGAVLVFGLAAMMPNGFTPVQLAIIGTVTSML LSSLSAAMSIYFQISQDLSFWYSARLHQMSPDFLKLAAPFFLIGIIMAISLSKKVTAV SLGDDISKSLGQKKKTIKIMAMLSVIILTGSAVALAGKIAFVGLVVPHITRFLVGSDY SRLIPCSCILGGIFLTLCDLASRFINYPFETPIEVVTSIIGVPFFLYLIKRKGGEQNG *" /label="feuB CDS" gene complement(180946..181950) /gene="feuB" /locus_tag="BSU_01620" /old_locus_tag="BSU01620" /label="feuB gene" CDS complement(181969..182922) /gene="feuA" /locus_tag="BSU_01630" /old_locus_tag="BSU01630" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8388528, 16889643, 17725565, 21802011, 22303020, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8388528, 16889643, 17725565, 21802011, 22303020, 25355936; Product type lp : lipoprotein" /codon_start=1 /transl_table=11 /product="ferri-bacillibactin-binding lipoprotein" /protein_id="NP_388044.1" /db_xref="EnsemblGenomes-Gn:BSU01630" /db_xref="EnsemblGenomes-Tr:CAB11939" /db_xref="GOA:P40409" /db_xref="InterPro:IPR002491" /db_xref="PDB:2PHZ" /db_xref="PDB:2WHY" /db_xref="PDB:2WI8" /db_xref="PDB:2XUZ" /db_xref="PDB:2XV1" /db_xref="SubtiList:BG10835" /db_xref="UniProtKB/Swiss-Prot:P40409" /translation="MKKISLTLLILLLALTAAACGSKNESTASKASGTASEKKKIEYL DKTYEVTVPTDKIAITGSVESMEDAKLLDVHPQGAISFSGKFPDMFKDITDKAEPTGE KMEPNIEKILEMKPDVILASTKFPEKTLQKISTAGTTIPVSHISSNWKENMMLLAQLT GKEKKAKKIIADYEQDLKEIKTKINDKAKDSKALVIRIRQGNIYIYPEQVYFNSTLYG DLGLKAPNEVKAAKAQELSSLEKLSEMNPDHIFVQFSDDENADKPDALKDLEKNPIWK SLKAVKEDHVYVNSVDPLAQGGTAWSKVRFLKAAAEKLTQN*" /label="feuA CDS" gene complement(181969..182922) /gene="feuA" /locus_tag="BSU_01630" /old_locus_tag="BSU01630" /label="feuA gene" promotor_-35 182282..182288 /Source="Nicolas_upshift_promotors" /id="U113" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=157 /SigmaFactorBS="gccttaaggcctaaatcaccgtatagtgtgGAGTTGAaatac acctgttcaGGGTAAATGTAAATGTTGCcttgtctgattctgatgacaagcgcttttg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 182303..182321 /Source="Nicolas_upshift_promotors" /id="U113" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=157 /SigmaFactorBS="gccttaaggcctaaatcaccgtatagtgtgGAGTTGAaatac acctgttcaGGGTAAATGTAAATGTTGCcttgtctgattctgatgacaagcgcttttg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 182312 /Source="Nicolas_upshifts" /id="U113" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=157 /SigmaFactorBS="gccttaaggcctaaatcaccgtatagtgtgGAGTTGAaatac acctgttcaGGGTAAATGTAAATGTTGCcttgtctgattctgatgacaagcgcttttg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(182953..182972) /Source="Nicolas_upshift_promotors" /id="U114" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.52947052947053" /psig="0.984015984015984" /xcortree=2097 /SigmaFactorBS="gtccatgataaatcaggaatttgtccatggtgttatatctgt tcattcTCTATAATTCCAATTGATAAtagttatcaattgaacaggaggctctatagat g" /listShort="feuA, feuB, feuC, ybbA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(182960) /Source="Nicolas_upshifts" /id="U114" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.52947052947053" /psig="0.984015984015984" /xcortree=2097 /SigmaFactorBS="gtccatgataaatcaggaatttgtccatggtgttatatctgt tcattcTCTATAATTCCAATTGATAAtagttatcaattgaacaggaggctctatagat g" /listShort="feuA, feuB, feuC, ybbA" /GFF_Attribute="listLong" /label="upshifts" CDS complement(183013..184602) /gene="btr" /locus_tag="BSU_01640" /old_locus_tag="BSU01640" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16889643, 17725565, 17962296, 22210890" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16889643, 17725565, 17962296, 22210890; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional activator (AraC/XylS family) of synthesis and uptake of the siderophore bacillibactin" /protein_id="NP_388045.1" /db_xref="EnsemblGenomes-Gn:BSU01640" /db_xref="EnsemblGenomes-Tr:CAB11940" /db_xref="GOA:P40408" /db_xref="InterPro:IPR002491" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR018060" /db_xref="InterPro:IPR018062" /db_xref="InterPro:IPR020449" /db_xref="SubtiList:BG10834" /db_xref="UniProtKB/Swiss-Prot:P40408" /translation="MQNAVIYQPVQIEYLKKTSDLFSEQQLADSFVLIFHLKGNGYIS IGTNTNPLQKKTLYVCPPNETFGFTPAADGHIDACIIRLLSYIKETGQDIFTPCTESE LAKLKLMNVSHIENLAVRLQELAALWNESSQLSQLKCVIEVQSLIYDLFTASLSDQTD THSAIEKTKHYIETHADTKITLAQLSQMAGISAKHYSESFKKWTGQSVTEFITKTRIT KAKRLMAKSNCKLKEIAHQTGYQDEFYFSRIFKKYTGCSPTSYMKKRRKKIAAYGRGT MGHLIPLHHIPFAAALHPKWTSYYYQHYSTDIPVQLSAYRFNEKWEENLYTLSQAEPD VIVSMDSISPEEQDRLNRIAEVMYLPSEESWRTHFLQTASFLKEESEAEKWLADYDQQ TTAAKKTLQHVQGLRFLFLRLHKQNFYLAHNRSVREVFFGDLGFSSATTADTPSEQAI SLENIANYQADCMMLFLFKEPETIAYYQQLQQTEAWQNLSAVRDNRVYLLSLDPWNEY SACGHERIVQQTVSLLSGDCP*" /label="btr CDS" gene complement(183013..184602) /gene="btr" /locus_tag="BSU_01640" /old_locus_tag="BSU01640" /label="btr gene" promotor_-10 complement(184643..184662) /Source="Nicolas_upshift_promotors" /id="U115" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.506493506493506" /psig=1 /xcortree=2112 /SigmaFactorBS="tttttttcatgctaaaaacccacccgctttaTATAGGAAaac tttcatttattTGGTACAATTTTTATTGAAAatgattatcaattgaaagcttctgaaa a" /listShort="ybbB, feuA, feuB, feuC, ybbA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(184655) /Source="Nicolas_upshifts" /id="U115" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.506493506493506" /psig=1 /xcortree=2112 /SigmaFactorBS="tttttttcatgctaaaaacccacccgctttaTATAGGAAaac tttcatttattTGGTACAATTTTTATTGAAAatgattatcaattgaaagcttctgaaa a" /listShort="ybbB, feuA, feuB, feuC, ybbA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(184677..184684) /Source="Nicolas_upshift_promotors" /id="U115" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.506493506493506" /psig=1 /xcortree=2112 /SigmaFactorBS="tttttttcatgctaaaaacccacccgctttaTATAGGAAaac tttcatttattTGGTACAATTTTTATTGAAAatgattatcaattgaaagcttctgaaa a" /listShort="ybbB, feuA, feuB, feuC, ybbA" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(184764) /Source="Nicolas_upshifts" /id="D59" /incds=0 /nref=19 /ntot=58 /MaxReadThrough="1.28464" /MaxDrop="7.13916" /score="9.64466628" /energy="-10.1" /TU="NA" /idTUdmin="U116" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(184793..186037) /gene="ybbC" /locus_tag="BSU_01650" /old_locus_tag="BSU01650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388046.1" /db_xref="EnsemblGenomes-Gn:BSU01650" /db_xref="EnsemblGenomes-Tr:CAB11941" /db_xref="InterPro:IPR008302" /db_xref="SubtiList:BG10833" /db_xref="UniProtKB/Swiss-Prot:P40407" /translation="MRKTIFAFLTGLMMFGTITAASASPDSKNQTAKKPKVQTGIDTL LPDYKKQLKGKRIGLITNPAGVNTSLKSSVDILYENPDIKLTALFGPEHGVRGDAQAG DEVGSYIDEKTGVPVYSLYGKTKKPTPEMLKNVDILMFDIQDVGTRFYTYIYTMAYAM EAAKENGIPFMVLDRPNPQGGNHIEGPILEPEYASFVGLYPIPLKHGMTIGELASLFN KEFSIDADLTVVKMKHWKRKMDFDDTRLPFVLPSPNMPTVESTFVYPATGLIEGTNIS EGRGTTKPFELIGAPFIKSTELEETLNSLHLPGVTFRAASFTPTFSKHQGTLCHGVQL YVTDRDKFEAVKTGLSVIKTIHDLYPEDFEFLSTGSFDKLAGNGWIRTKIENGTSVEN IINSYEKTLQQFSKTRKKYLIY*" /label="ybbC CDS" gene complement(184793..186037) /gene="ybbC" /locus_tag="BSU_01650" /old_locus_tag="BSU01650" /label="ybbC gene" downshifts complement(184814) /Source="Nicolas_upshifts" /id="D60" /incds=0 /nref=11 /ntot=122 /MaxReadThrough="7.66074" /MaxDrop="4.10379" /score="9.64466628" /energy="-10.1" /TU="U116" /idTUdmin="U116" /TUdmin="-50" /isTUend="FALSE" /label="downshifts" CDS complement(186051..187979) /gene="nagZ" /locus_tag="BSU_01660" /old_locus_tag="BSU01660" /EC_number="3.2.1.52" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8063094, 20400549, 20826810, 23177201, 26963691" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8063094, 20400549, 20826810, 23177201, 26963691; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylglucosaminidase lipoprotein" /protein_id="NP_388047.1" /db_xref="EnsemblGenomes-Gn:BSU01660" /db_xref="EnsemblGenomes-Tr:CAB11942" /db_xref="GOA:P40406" /db_xref="InterPro:IPR001764" /db_xref="InterPro:IPR002772" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR019800" /db_xref="InterPro:IPR036881" /db_xref="InterPro:IPR036962" /db_xref="PDB:3BMX" /db_xref="PDB:3LK6" /db_xref="PDB:3NVD" /db_xref="PDB:4GYJ" /db_xref="PDB:4GYK" /db_xref="SubtiList:BG10832" /db_xref="UniProtKB/Swiss-Prot:P40406" /translation="MRPVFPLILSAVLFLSCFFGARQTEASASKRAIDANQIVNRMSL DEKLGQMLMPDFRNWQKEGESSPQALTKMNDEVASLVKKYQFGGIILFAENVKTTKQT VQLTDDYQKASPKIPLMLSIDQEGGIVTRLGEGTNFPGNMALGAARSRINAYQTGSII GKELSALGINTDFSPVVDINNNPDNPVIGVRSFSSNRELTSRLGLYTMKGLQRQDIAS ALKHFPGHGDTDVDSHYGLPLVSHGQERLREVELYPFQKAIDAGADMVMTAHVQFPAF DDTTYKSKLDGSDILVPATLSKKVMTGLLRQEMGFNGVIVTDALNMKAIADHFGQEEA VVMAVKAGVDIALMPASVTSLKEEQKFARVIQALKEAVKNGDIPEQQINNSVERIISL KIKRGMYPARNSDSTKEKIAKAKKIVGSKQHLKAEKKLAEKAVTVLKNEQHTLPFKPK KGSRILIVAPYEEQTASIEQTIHDLIKRKKIKPVSLSKMNFASQVFKTEHEKQVKEAD YIITGSYVVKNDPVVNDGVIDDTISDSSKWATVFPRAVMKAALQHNKPFVLMSLRNPY DAANFEEAKALIAVYGFKGYANGRYLQPNIPAGVMAIFGQAKPKGTLPVDIPSVTKPG NTLYPLGYGLNIKTGRPL*" /label="nagZ CDS" gene complement(186051..187979) /gene="nagZ" /locus_tag="BSU_01660" /old_locus_tag="BSU01660" /label="nagZ gene" CDS complement(188007..189332) /gene="amiE" /locus_tag="BSU_01670" /old_locus_tag="BSU01670" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16452451, 20400549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16452451, 20400549; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="amidase hydrolyzing N-acetylmuramyl-L-Ala bond of MurNAc peptides" /protein_id="NP_388048.2" /db_xref="EnsemblGenomes-Gn:BSU01670" /db_xref="EnsemblGenomes-Tr:CAB11943" /db_xref="InterPro:IPR001466" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR022849" /db_xref="SubtiList:BG11566" /db_xref="UniProtKB/Swiss-Prot:O05213" /translation="MKTKTLFIFSAILTLSIFAPNETFAQTAGNLIEPKIINAETAQF STKKLRKVDQMIERDIAAGFPGAVLVVVKDGRIIKKAAYGYSKKYEGSELLRRPAKMK TRTMFDLASNTKMYATNFALQRLVSQGKLDVYEKVSAYLPGFKDQPGDLIKGKDKIRV IDVLQHQSGLPSSFYFYTPEKAGKYYSQERDKTIEYLTKIPLDYQTGTKHVYSDIGYM LLGCIVEKLTGKPLDVYTEQELYKPLRLKHTLYNPLQKGFKPKQFAATERMGNTRDGV IQFPNIRTNTLQGEVHDEKAFYSMDGVSGHAGLFSNADDMAILLQVMLNKGSYRNISL FDQKTADLFTAPSATDPTFALGWRRNGSKSMEWMFGPHASENAYGHTGWTGTVTIIDP AYNLGIALLTNKKHTPVIDPEENPNVFEGDQFPTGSYGSVITAIYEAME*" /label="amiE CDS" gene complement(188007..189332) /gene="amiE" /locus_tag="BSU_01670" /old_locus_tag="BSU01670" /label="amiE gene" CDS complement(189389..190756) /gene="murP" /locus_tag="BSU_01680" /old_locus_tag="BSU01680" /EC_number="2.7.1.192" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15060041, 15849754, 16850406, 10627040, 20400549, 22960854; Product type t : transporter" /codon_start=1 /transl_table=11 /product="N-acetylmuramic acid PTS permease-MurP subunit" /protein_id="NP_388049.3" /db_xref="EnsemblGenomes-Gn:BSU01680" /db_xref="EnsemblGenomes-Tr:CAB11944" /db_xref="GOA:Q797S1" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="SubtiList:BG11567" /db_xref="UniProtKB/Swiss-Prot:Q797S1" /translation="MSKENNYHHLAQKILELCGGKSNISSYTHCMTRLRITPYDESKA DAQALRKLDGVLGVVEAETLQIILGTGVVNHVTAAFSKLVSAEEGADVKEAAAKKKAD INRKNATPFKLFLRKIASIFIPLIPALVASGLITGITKAIIQAGWLSADSQIAIILTV IGSGLFTYLGILVGINASKEFGGTPALGALAGILIINPEIAKISLFGEELLPGRGGLI GVLFAAIFIAYTEQFIRRFIPQSLDIIVTPTVSLLITGIVTYVVFMPLGGFISDAITS GLLSILDIGGIAAGFILGATFLPLVVTGLHQGLTPVHMELINSIGNDPLLPILAMGGA GQVGAAFAVFVKTKKTTLRKAIAGGLPSGLLGIGEPLIFGVTLPLGRPFLTACLGAGI GGAFQAYFQVATIAIGVSGLPLSFLVLPSQIILYIVGLFISYAAGFLLTYAFGYKDEM ASQFD*" /label="murP CDS" gene complement(189389..190756) /gene="murP" /locus_tag="BSU_01680" /old_locus_tag="BSU01680" /label="murP gene" CDS complement(190782..191633) /gene="murR" /locus_tag="BSU_01690" /old_locus_tag="BSU01690" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 20400549; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator MurR-N-acetylmuramic acid" /protein_id="NP_388050.1" /db_xref="EnsemblGenomes-Gn:BSU01690" /db_xref="EnsemblGenomes-Tr:CAB11945" /db_xref="GOA:Q45581" /db_xref="InterPro:IPR000281" /db_xref="InterPro:IPR001347" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR035472" /db_xref="InterPro:IPR036388" /db_xref="PDB:2O3F" /db_xref="SubtiList:BG11569" /db_xref="UniProtKB/Swiss-Prot:Q45581" /translation="MATGGLAIIQSMKHKLPPSERKLADYILAHPHKAIESTVNEISA LANSSDAAVIRLCKSLGLKGFQDLKMRVAGDLAKPTFQGYRDIVPHEPLPSISEKTAG NAIQAIQDTSDLMDYKELERAVSLLLKAHTVHFIGLGASGIVAKDAQQKWLRIHKQAT AFTDTHLVASLIANADKDDIVFAISFSGETQEIVELFAMAKEKGITTISLTQFSQTSV SALADVPLYTAHSNEALIRSAATSSRLAQLFIIDVLFLGMAAEQYETTTGYIDKTRAA IQSMRIK*" /label="murR CDS" gene complement(190782..191633) /gene="murR" /locus_tag="BSU_01690" /old_locus_tag="BSU01690" /label="murR gene" CDS complement(191650..192564) /gene="murQ" /locus_tag="BSU_01700" /old_locus_tag="BSU01700" /EC_number="4.2.1.126" /function="16.13: Shape" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15983044, 20400549, 16452451; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-lactyl ether N-acetylmuramic-6-phosphate acid etherase" /protein_id="NP_388051.1" /db_xref="EnsemblGenomes-Gn:BSU01700" /db_xref="EnsemblGenomes-Tr:CAB11946" /db_xref="GOA:Q45582" /db_xref="InterPro:IPR001347" /db_xref="InterPro:IPR005486" /db_xref="InterPro:IPR005488" /db_xref="SubtiList:BG11570" /db_xref="UniProtKB/Swiss-Prot:Q45582" /translation="MSEPLNLHRLTTESRNSQTVEIHKANTLGILKMINNEDMKVAAA VQEVLPDIKTAVDCAYESFQNGGRLIYTGAGTSGRLGVMDAVECPPTYSVSPDQVIGI MAGGPEAFLQAAEGIEDSEEAGAEDLRNIQLTSNDTVIAIAASGRTPYAAGALRYARK VGAHTIALTCNENSAISKDADHSIEVVVGPEAITGSTRMKAATAHKMILNMISTAVMV KIGKVYENLMVDVNVSNKKLKERAISIIQSLTNASYDTARYTLEQADHHVKTAIVMLK TSTDQKQAQTLLDEANGFIDKAIEHYHP*" /label="murQ CDS" gene complement(191650..192564) /gene="murQ" /locus_tag="BSU_01700" /old_locus_tag="BSU01700" /label="murQ gene" promotor_-10 complement(192595..192613) /Source="Nicolas_upshift_promotors" /id="U116" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.25974025974026" /psig="0.681318681318681" /xcortree=765 /SigmaFactorBS="agtgaaataaaatttcaaaaatttaaaaacatAGTTGAAAta tcataacagaaatGAATATACTGAATATTGAGatatatcattttaaaacagggggcat c" /listShort="murQ, ybbH, ybbF, ybbE, ybbD, ybbC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(192608) /Source="Nicolas_upshifts" /id="U116" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.25974025974026" /psig="0.681318681318681" /xcortree=765 /SigmaFactorBS="agtgaaataaaatttcaaaaatttaaaaacatAGTTGAAAta tcataacagaaatGAATATACTGAATATTGAGatatatcattttaaaacagggggcat c" /listShort="murQ, ybbH, ybbF, ybbE, ybbD, ybbC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(192629..192636) /Source="Nicolas_upshift_promotors" /id="U116" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.25974025974026" /psig="0.681318681318681" /xcortree=765 /SigmaFactorBS="agtgaaataaaatttcaaaaatttaaaaacatAGTTGAAAta tcataacagaaatGAATATACTGAATATTGAGatatatcattttaaaacagggggcat c" /listShort="murQ, ybbH, ybbF, ybbE, ybbD, ybbC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(192674..193156) /gene="ybbJ" /locus_tag="BSU_01710" /old_locus_tag="BSU01710" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyltransferase" /protein_id="NP_388052.2" /db_xref="EnsemblGenomes-Gn:BSU01710" /db_xref="EnsemblGenomes-Tr:CAB11947" /db_xref="GOA:Q45583" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG11571" /db_xref="UniProtKB/Swiss-Prot:Q45583" /translation="MTQDISLSFYKPEHLPELQSFTLTNDDKRFTSLPKEVLSQALGI QDRYPVVILKDDLPVGFFILHASKETLASYSNNPFALLLSSLSLTAVHHGKGYAKKAM LLLPAFVSGYFPWCDEIILAVNHLNIRAKHLYMKSGFLDKGRRRIGPLGEQLILHHFL *" /label="ybbJ CDS" gene complement(192674..193156) /gene="ybbJ" /locus_tag="BSU_01710" /old_locus_tag="BSU01710" /label="ybbJ gene" CDS complement(193169..193624) /gene="ybbK" /locus_tag="BSU_01720" /old_locus_tag="BSU01720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388053.2" /db_xref="EnsemblGenomes-Gn:BSU01720" /db_xref="EnsemblGenomes-Tr:CAB11948" /db_xref="InterPro:IPR007553" /db_xref="SubtiList:BG11572" /db_xref="UniProtKB/Swiss-Prot:Q45584" /translation="MILVSSCLGGIECRYNGSHAASEKIRKLVDEKKAVMACPELLGG FSTPREPAEIIGGTGEDVLNGTAKIVTASGEDVTELYMEGAAKTLAYAKEINASAVIL KENSPSCGSGFIYNGTFSGKKITGSGVTAALLKQAGYRVISENELNDIL*" /label="ybbK CDS" gene complement(193169..193624) /gene="ybbK" /locus_tag="BSU_01720" /old_locus_tag="BSU01720" /label="ybbK gene" promotor_-10 complement(193650..193669) /Source="Nicolas_upshift_promotors" /id="U117" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.7002997002997" /psig="0.992007992007992" /xcortree=3038 /SigmaFactorBS="ttttttattttcaaactttttaactccttttttaactgaaaa agccTCccaactaaagccatTTATTTTATGATAGAGACAAgcaaagcaagagaggaga a" /listShort="ybbK, ybbJ, murQ, ybbH, ybbF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(193671) /Source="Nicolas_upshifts" /id="U117" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.7002997002997" /psig="0.992007992007992" /xcortree=3038 /SigmaFactorBS="ttttttattttcaaactttttaactccttttttaactgaaaa agccTCccaactaaagccatTTATTTTATGATAGAGACAAgcaaagcaagagaggaga a" /listShort="ybbK, ybbJ, murQ, ybbH, ybbF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(193684..193685) /Source="Nicolas_upshift_promotors" /id="U117" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.7002997002997" /psig="0.992007992007992" /xcortree=3038 /SigmaFactorBS="ttttttattttcaaactttttaactccttttttaactgaaaa agccTCccaactaaagccatTTATTTTATGATAGAGACAAgcaaagcaagagaggaga a" /listShort="ybbK, ybbJ, murQ, ybbH, ybbF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 193744..193751 /Source="Nicolas_upshift_promotors" /id="U118" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.853146853146853" /psig=1 /xcortree=2416 /SigmaFactorBS="tttgaaaataaaaaatttaattttcctCTTTACAAacagggg gtgacctGTATATAATAACTTTTGTCAgctcgacgagaacacaacggcccgttggtca a" /listShort="trnSL-Glu2, trnSL-Val1, trnSL-Thr1, trnSL-Tyr1, trnSL-Gln2, S67" /listLong="sigW, rsiW, S68, ybbP, ybbR, glmM, NA, S69, glmS" /label="promotor_-35" promotor_-10 193766..193785 /Source="Nicolas_upshift_promotors" /id="U118" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.853146853146853" /psig=1 /xcortree=2416 /SigmaFactorBS="tttgaaaataaaaaatttaattttcctCTTTACAAacagggg gtgacctGTATATAATAACTTTTGTCAgctcgacgagaacacaacggcccgttggtca a" /listShort="trnSL-Glu2, trnSL-Val1, trnSL-Thr1, trnSL-Tyr1, trnSL-Gln2, S67" /listLong="sigW, rsiW, S68, ybbP, ybbR, glmM, NA, S69, glmS" /label="promotor_-10" upshifts 193777 /Source="Nicolas_upshifts" /id="U118" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.853146853146853" /psig=1 /xcortree=2416 /SigmaFactorBS="tttgaaaataaaaaatttaattttcctCTTTACAAacagggg gtgacctGTATATAATAACTTTTGTCAgctcgacgagaacacaacggcccgttggtca a" /listShort="trnSL-Glu2, trnSL-Val1, trnSL-Thr1, trnSL-Tyr1, trnSL-Gln2, S67" /listLong="sigW, rsiW, S68, ybbP, ybbR, glmM, NA, S69, glmS" /label="upshifts" tRNA 193804..193878 /gene="trnSL-Glu2" /locus_tag="BSU_tRNA_75" /product="tRNA-Glu" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Glu(UUC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Glu2 tRNA" gene 193804..193878 /gene="trnSL-Glu2" /locus_tag="BSU_tRNA_75" /label="trnSL-Glu2 gene" tRNA 193882..193957 /gene="trnSL-Val1" /locus_tag="BSU_tRNA_78" /product="tRNA-Val" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Val(UAC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Val1 tRNA" gene 193882..193957 /gene="trnSL-Val1" /locus_tag="BSU_tRNA_78" /label="trnSL-Val1 gene" tRNA 193962..194034 /gene="trnSL-Thr1" /locus_tag="BSU_tRNA_76" /product="tRNA-Thr" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Thr(UGU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Thr1 tRNA" gene 193962..194034 /gene="trnSL-Thr1" /locus_tag="BSU_tRNA_76" /label="trnSL-Thr1 gene" tRNA 194057..194141 /gene="trnSL-Tyr1" /locus_tag="BSU_tRNA_77" /product="tRNA-Tyr" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Tyr(GAU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Tyr1 tRNA" gene 194057..194141 /gene="trnSL-Tyr1" /locus_tag="BSU_tRNA_77" /label="trnSL-Tyr1 gene" tRNA 194146..194220 /gene="trnSL-Gln2" /locus_tag="BSU_tRNA_74" /product="tRNA-Gln" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Gln(UUG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Gln2 tRNA" gene 194146..194220 /gene="trnSL-Gln2" /locus_tag="BSU_tRNA_74" /label="trnSL-Gln2 gene" downshifts 194223 /Source="Nicolas_upshifts" /id="D61" /incds=0 /nref=10 /ntot=91 /MaxReadThrough="4.25215" /MaxDrop="3.84626" /score="25.5087424" /energy="-11.4" /TU="U118" /idTUdmin="U118" /TUdmin="-176" /isTUend="FALSE" /label="downshifts" S_feature 194268..194385 /Source="Nicolas_S_feature" /locus_tag="new_194669_194786" /HighExp="Paraq, BMM, H2O2, Heat, G180, G135, Oxctl, G150, C30, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S67" promotor_-35 194386..194395 /Source="Nicolas_upshift_promotors" /id="U119" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1680 /SigmaFactorBS="ttcacgaattaccatctacaccctgccaaaaatttgataaac ttattttataaaaaaatTGAAACCTTTtgaaacgaagcTCGTATACATACAGACcggt g" /listShort="sigW, rsiW" /listLong="S68, ybbP, ybbR, glmM, NA, S69, glmS" /label="promotor_-35" upshifts 194387 /Source="Nicolas_upshifts" /id="U119" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1680 /SigmaFactorBS="ttcacgaattaccatctacaccctgccaaaaatttgataaac ttattttataaaaaaatTGAAACCTTTtgaaacgaagcTCGTATACATACAGACcggt g" /listShort="sigW, rsiW" /listLong="S68, ybbP, ybbR, glmM, NA, S69, glmS" /label="upshifts" promotor_-10 194407..194422 /Source="Nicolas_upshift_promotors" /id="U119" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1680 /SigmaFactorBS="ttcacgaattaccatctacaccctgccaaaaatttgataaac ttattttataaaaaaatTGAAACCTTTtgaaacgaagcTCGTATACATACAGACcggt g" /listShort="sigW, rsiW" /listLong="S68, ybbP, ybbR, glmM, NA, S69, glmS" /label="promotor_-10" CDS 194448..195011 /gene="sigW" /locus_tag="BSU_01730" /old_locus_tag="BSU01730" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11866510, 15130127, 16629676, 21542858, 28319136, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11866510, 15130127, 16629676, 21542858, 28319136, 22720735; Product type r : regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase ECF(extracytoplasmic function)-type sigma factor W" /protein_id="NP_388054.1" /db_xref="EnsemblGenomes-Gn:BSU01730" /db_xref="EnsemblGenomes-Tr:CAB11949" /db_xref="GOA:Q45585" /db_xref="InterPro:IPR000838" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013249" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR014294" /db_xref="InterPro:IPR036388" /db_xref="PDB:5WUQ" /db_xref="PDB:5WUR" /db_xref="SubtiList:BG11573" /db_xref="UniProtKB/Swiss-Prot:Q45585" /translation="MEMMIKKRIKQVKKGDQDAFADIVDIYKDKIYQLCYRMLGNVHE AEDIAQEAFIRAYVNIDSFDINRKFSTWLYRIATNLTIDRIRKKKPDYYLDAEVAGTE GLTMYSQIVADGVLPEDAVVSLELSNTIQQKILKLPDKYRTVIVLKYIDELSLIEIGE ILNIPVGTVKTRIHRGREALRKQLRDL*" /label="sigW CDS" gene 194448..195011 /gene="sigW" /locus_tag="BSU_01730" /old_locus_tag="BSU01730" /label="sigW gene" CDS 195025..195651 /gene="rsiW" /locus_tag="BSU_01740" /old_locus_tag="BSU01740" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15130127, 28319136, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15130127, 28319136, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="anti-sigma(W) factor" /protein_id="NP_388055.1" /db_xref="EnsemblGenomes-Gn:BSU01740" /db_xref="EnsemblGenomes-Tr:CAB11950" /db_xref="GOA:Q45588" /db_xref="InterPro:IPR027383" /db_xref="PDB:5WUQ" /db_xref="PDB:5WUR" /db_xref="SubtiList:BG11574" /db_xref="UniProtKB/Swiss-Prot:Q45588" /translation="MSCPEQIVQLMHMHLDGDILPKDEHVLNEHLETCEKCRKHFYEM EKSIALVRSTSHVEAPADFTANVMAKLPKEKKRASVKRWFRTHPVIAAAAVFIILMGG GFFNSWHNDHNFSVSKQPNLVVHNHTVTVPEGETVKGDVTVKNGKLIIKGKIDGDVTV VNGEKYMASAGQVTGQIEEINQLFDWTWYKMKSAGKSVLDAFNPNGEE*" /label="rsiW CDS" gene 195025..195651 /gene="rsiW" /locus_tag="BSU_01740" /old_locus_tag="BSU01740" /label="rsiW gene" downshifts complement(195443) /Source="Nicolas_upshifts" /id="D62" /incds=1 /nref=2 /ntot=181 /MaxReadThrough="1.52124" /MaxDrop="3.24828" /score="0.305471631" /energy="-6.9" /TU="NA" /idTUdmin="U120" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_no_box complement(195601..195701) /Source="Nicolas_upshift_promotors" /id="U120" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95904095904096" /psig="0.002997002997003" /xcortree=56 /SigmaFactorBS="tgtgccagccctctcagcccgcaaaaaaagagcaaagcggct aacgcgctttactcttctccgttcggattgaatgcatcgagtacacttttccccgcag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" downshifts 195631 /Source="Nicolas_upshifts" /id="D63" /incds=0 /nref=251 /ntot=269 /MaxReadThrough="4.26924" /MaxDrop="8.34597" /score="7.39786279" /energy="-10.8" /TU="U119" /idTUdmin="U119" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" upshifts complement(195641) /Source="Nicolas_upshifts" /id="U120" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95904095904096" /psig="0.002997002997003" /xcortree=56 /SigmaFactorBS="tgtgccagccctctcagcccgcaaaaaaagagcaaagcggct aacgcgctttactcttctccgttcggattgaatgcatcgagtacacttttccccgcag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 195700..195707 /Source="Nicolas_upshift_promotors" /id="U121" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.73026973026973" /psig=1 /xcortree=1886 /SigmaFactorBS="tctttttttgcgggctgagagggctggcaCATTTCACttgct aaatcgaaaTGTGGTATAATGGGCTCGCTatgtaaagtacatatgcgtaacacgtaaa a" /listShort="S68, ybbP, ybbR, glmM" /listLong="NA, S69, glmS" /label="promotor_-35" promotor_-10 195722..195741 /Source="Nicolas_upshift_promotors" /id="U121" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.73026973026973" /psig=1 /xcortree=1886 /SigmaFactorBS="tctttttttgcgggctgagagggctggcaCATTTCACttgct aaatcgaaaTGTGGTATAATGGGCTCGCTatgtaaagtacatatgcgtaacacgtaaa a" /listShort="S68, ybbP, ybbR, glmM" /listLong="NA, S69, glmS" /label="promotor_-10" S_feature 195731..195811 /Source="Nicolas_S_feature" /locus_tag="new_196132_196212" /HighExp="dia5, Diami, H2O2, dia15, G135, Cold, G180, Paraq, G150, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigWXY, SigA" /TUlongPSig="1, 1" /label="S68" upshifts 195731 /Source="Nicolas_upshifts" /id="U121" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.73026973026973" /psig=1 /xcortree=1886 /SigmaFactorBS="tctttttttgcgggctgagagggctggcaCATTTCACttgct aaatcgaaaTGTGGTATAATGGGCTCGCTatgtaaagtacatatgcgtaacacgtaaa a" /listShort="S68, ybbP, ybbR, glmM" /listLong="NA, S69, glmS" /label="upshifts" CDS 195812..196633 /gene="cdaA" /locus_tag="BSU_01750" /old_locus_tag="BSU01750" /EC_number="2.7.7.85" /function="16.13: Shape" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:19901023, 21566650, 23192352, 25605729, 25616256, 26240071, 28420751" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19901023, 21566650, 23192352, 25605729, 25616256, 26240071, 28420751; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="diadenylate cyclase" /protein_id="NP_388056.2" /db_xref="EnsemblGenomes-Gn:BSU01750" /db_xref="EnsemblGenomes-Tr:CAB11951" /db_xref="GOA:Q45589" /db_xref="InterPro:IPR003390" /db_xref="InterPro:IPR014046" /db_xref="InterPro:IPR034701" /db_xref="InterPro:IPR036888" /db_xref="SubtiList:BG11577" /db_xref="UniProtKB/Swiss-Prot:Q45589" /translation="MAFEDIPFLQYLGNAVDILLVWYVIYKLIMVIRGTKAVQLLKGI VVIVLVRMASQYLGLSTLQWLMDQAITWGFLAIIIIFQPELRRALEQLGRGRFFSRSG TPVEEAQQKTIEAITKAINYMAKRRIGALLTIERDTGMGDYIETGIPLNAKVSSELLI NIFIPNTPLHDGAVIMKNNEIAAAACYLPLSESPFISKELGTRHRAAVGISEVTDSLT IIVSEETGGVSVAKNGDLHRELTEEALKEMLEAEFKKNTRDTSSNRWYWRGKKNG*" /label="cdaA CDS" gene 195812..196633 /gene="cdaA" /locus_tag="BSU_01750" /old_locus_tag="BSU01750" /label="cdaA gene" CDS 196626..198077 /gene="cdaR" /locus_tag="BSU_01760" /old_locus_tag="BSU01760" /experiment="publication(s) with functional evidences, PMID:16236721, 17406245, 20094656, 21154411, 22720735, 23192352, 27074767" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16236721, 17406245, 20094656, 21154411, 22720735, 23192352, 27074767; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of diadenylate cyclase activity" /protein_id="NP_388057.2" /db_xref="EnsemblGenomes-Gn:BSU01760" /db_xref="EnsemblGenomes-Tr:CAB11952" /db_xref="GOA:O34659" /db_xref="InterPro:IPR012505" /db_xref="InterPro:IPR015943" /db_xref="SubtiList:BG12703" /db_xref="UniProtKB/Swiss-Prot:O34659" /translation="MDKFLNNRWAVKIIALLFALLLYVAVNSNQAPTPKKPGESFFPT STTDEATLTDIPVKAYYDDENYVVTGVPQTVNVTIKGSTSAVKKARQTKNFEIYADME HLKTGTHKVELKAKNVSDGLTISINPSVTTVTIQERTTKSFPVEVEYYNKSKMKKGYS PEQPIVSPKNVQITGSKNVIDNISLVKASVNLENADETIEKEAKVTVYDKDGNALPVD VEPSVIKITVPVTSPSKKVPFKIERTGSLPDGVSIANIESSPSEVTVYGSQDVLDSLE FIDGVSLDLSKINKDSDIEADIPLPDGVKKISPSKVTLHIEVDSEADQKFENVPIKTV GLSSSQNIEFLDPESQAIDVTAKGSPTNINKLKKSDIELYVNVSDLEDGEHSVKLEVN GPQNVTWSLGRKNAKIKLTSKKSNTSTNDNSSNTSGNQDTDKQTNDQKNNQQEDTKNT DKNNNDQNQDGNKDQNQDQDEDESTANSQSSSE*" /label="cdaR CDS" gene 196626..198077 /gene="cdaR" /locus_tag="BSU_01760" /old_locus_tag="BSU01760" /label="cdaR gene" CDS 198096..199442 /gene="glmM" /locus_tag="BSU_01770" /old_locus_tag="BSU01770" /EC_number="5.4.2.10" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10671448, 10913078, 12089032, 21154411, 26240071, 27074767" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10671448, 10913078, 12089032, 21154411, 26240071, 27074767; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="phosphoglucosamine mutase" /protein_id="NP_388058.1" /db_xref="EnsemblGenomes-Gn:BSU01770" /db_xref="EnsemblGenomes-Tr:CAB11953" /db_xref="GOA:O34824" /db_xref="InterPro:IPR005841" /db_xref="InterPro:IPR005843" /db_xref="InterPro:IPR005844" /db_xref="InterPro:IPR005845" /db_xref="InterPro:IPR005846" /db_xref="InterPro:IPR006352" /db_xref="InterPro:IPR016055" /db_xref="InterPro:IPR016066" /db_xref="InterPro:IPR036900" /db_xref="SubtiList:BG12704" /db_xref="UniProtKB/Swiss-Prot:O34824" /translation="MGKYFGTDGVRGVANSELTPELAFKVGRFGGYVLTKDKQRPKVL IGRDTRISGHMLEGALVAGLLSIGAEVMRLGVISTPGVSYLTKAMDAEAGVMISASHN PVQDNGIKFFGGDGFKLSDEQEAEIERLMDEPEDKLPRPVGADLGLVNDYFEGGQKYL QFLKQTADEDFTGIHVALDCANGATSSLATHLFADLDADVSTMGTSPNGLNINDGVGS THPEALSAFVKEKNADLGLAFDGDGDRLIAVDEKGNIVDGDQIMYICSKHLKSEGRLK DDTVVSTVMSNLGFYKALEKEGIKSVQTAVGDRYVVEAMKKDGYNVGGEQSGHLIFLD YNTTGDGLLSAIMLMNTLKATGKPLSELAAEMQKFPQLLVNVRVTDKYKVEENEKVKA VISEVEKEMNGDGRILVRPSGTEPLVRVMAEAKTKELCDEYVNRIVEVVRSEMGLE*" /label="glmM CDS" gene 198096..199442 /gene="glmM" /locus_tag="BSU_01770" /old_locus_tag="BSU01770" /label="glmM gene" downshifts 199437 /Source="Nicolas_upshifts" /id="D64" /incds=0 /nref=126 /ntot=216 /MaxReadThrough="5.32721" /MaxDrop="5.02497" /score="13.5044076" /energy="-17.5" /TU="U121" /idTUdmin="U121" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" promotor_-35 199461..199469 /Source="Nicolas_upshift_promotors" /id="U122" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.754245754245754" /psig="0.754245754245754" /xcortree=649 /SigmaFactorBS="tccggtcagaaatgggattagagtaacgaagtctattatcag agAGTGAACAAgacaagcgaggttTACATAAGATAATTGTGAGAcatacggcaaagtt g" /listShort="NA, S69, glmS" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 199477 /Source="Nicolas_upshifts" /id="U122" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.754245754245754" /psig="0.754245754245754" /xcortree=649 /SigmaFactorBS="tccggtcagaaatgggattagagtaacgaagtctattatcag agAGTGAACAAgacaagcgaggttTACATAAGATAATTGTGAGAcatacggcaaagtt g" /listShort="NA, S69, glmS" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 199483..199502 /Source="Nicolas_upshift_promotors" /id="U122" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.754245754245754" /psig="0.754245754245754" /xcortree=649 /SigmaFactorBS="tccggtcagaaatgggattagagtaacgaagtctattatcag agAGTGAACAAgacaagcgaggttTACATAAGATAATTGTGAGAcatacggcaaagtt g" /listShort="NA, S69, glmS" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 199529..199534 /Source="Nicolas_upshift_promotors" /id="U123" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.623376623376623" /psig="0.999000999001" /xcortree=1722 /SigmaFactorBS="tgtgagacatacggcaaagttgcttaaaaaacaATTGACcgt ttatgccacatgTTGTAAAATCAAGCTTGTCTtgttcttattttctcaataggaaaag a" /listShort="NA, S69, glmS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 199550..199569 /Source="Nicolas_upshift_promotors" /id="U123" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.623376623376623" /psig="0.999000999001" /xcortree=1722 /SigmaFactorBS="tgtgagacatacggcaaagttgcttaaaaaacaATTGACcgt ttatgccacatgTTGTAAAATCAAGCTTGTCTtgttcttattttctcaataggaaaag a" /listShort="NA, S69, glmS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 199556 /Source="Nicolas_upshifts" /id="U123" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.623376623376623" /psig="0.999000999001" /xcortree=1722 /SigmaFactorBS="tgtgagacatacggcaaagttgcttaaaaaacaATTGACcgt ttatgccacatgTTGTAAAATCAAGCTTGTCTtgttcttattttctcaataggaaaag a" /listShort="NA, S69, glmS" /GFF_Attribute="listLong" /label="upshifts" misc_feature 199600..199616 /Source="Nicolas_upshift_promotors" /id="U124" /multdbtbs="-" /comp="M18" /sig="Sig-" /pcomp="0.497502497502497" /psig="0.497502497502497" /xcortree=336 /SigmaFactorBS="taaaatcaagcttgtcttgttcttattttctcaataggaaaa gaagaCGGGATTATTGCTTTACctataattatagcgcccgaactaagcgcccggaaaa a" /listShort="NA, S69, glmS" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 199613 /Source="Nicolas_upshifts" /id="U124" /multdbtbs="-" /comp="M18" /sig="Sig-" /pcomp="0.497502497502497" /psig="0.497502497502497" /xcortree=336 /SigmaFactorBS="taaaatcaagcttgtcttgttcttattttctcaataggaaaa gaagaCGGGATTATTGCTTTACctataattatagcgcccgaactaagcgcccggaaaa a" /listShort="NA, S69, glmS" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 199616..199786 /gene="glmSA" /locus_tag="BSU_misc_RNA_5" /product="riboswitch and ribozyme (GlmS-glucosamine-6-P)" /experiment="publication(s) with functional evidences, PMID:16298301, 16484375, 16990543, 17114942, 17283212, 18079181, 19228039, 21317896, 21395279, 21936556, 25038539, 26240071, 28012261" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16298301, 16484375, 16990543, 17114942, 17283212, 18079181, 19228039, 21317896, 21395279, 21936556, 25038539, 26240071, 28012261; Product type n: RNA" /label="glmSA RNA" gene 199616..199786 /gene="glmSA" /locus_tag="BSU_misc_RNA_5" /label="glmSA gene" S_feature 199787..199875 /Source="Nicolas_S_feature" /locus_tag="new_200188_200276" /HighExp="M40t90, M0t90, M9-stat, Lbstat, T2.30H, T2.0H, T3.0H, T1.30H, T1.0H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, SigK" /TUshortPSig="0.498, 0.999, 0.754" /TUlongSig="SigA, SigWXY, SigA" /TUlongPSig="1, 1, 1" /label="S69" CDS 199876..201678 /gene="glmS" /locus_tag="BSU_01780" /old_locus_tag="BSU01780" /EC_number="2.6.1.16" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 15029187, 17114942, 17283212, 17322533, 23874669; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="L-glutamine-D-fructose-6-phosphate amidotransferase" /protein_id="NP_388059.1" /db_xref="EnsemblGenomes-Gn:BSU01780" /db_xref="EnsemblGenomes-Tr:CAB11954" /db_xref="GOA:P0CI73" /db_xref="InterPro:IPR001347" /db_xref="InterPro:IPR005855" /db_xref="InterPro:IPR017932" /db_xref="InterPro:IPR029055" /db_xref="InterPro:IPR035466" /db_xref="InterPro:IPR035490" /db_xref="SubtiList:BG10948" /db_xref="UniProtKB/Swiss-Prot:P0CI73" /translation="MCGIVGYIGQLDAKEILLKGLEKLEYRGYDSAGIAVANEQGIHV FKEKGRIADLREVVDANVEAKAGIGHTRWATHGEPSYLNAHPHQSALGRFTLVHNGVI ENYVQLKQEYLQDVELKSDTDTEVVVQVIEQFVNGGLETEEAFRKTLTLLKGSYAIAL FDNDNRETIFVAKNKSPLLVGLGDTFNVVASDAMAMLQVTNEYVELMDKEMVIVTDDQ VVIKNLDGDVITRASYIAELDASDIEKGTYPHYMLKETDEQPVVMRKIIQTYQDENGK LSVPGDIAAAVAEADRIYIIGCGTSYHAGLVGKQYIEMWANVPVEVHVASEFSYNMPL LSKKPLFIFLSQSGETADSRAVLVQVKALGHKALTITNVPGSTLSREADYTLLLHAGP EIAVASTKAYTAQIAVLAVLASVAADKNGINIGFDLVKELGIAANAMEALCDQKDEME MIAREYLTVSRNAFFIGRGLDYFVCVEGALKLKEISYIQAEGFAGGELKHGTIALIEQ GTPVFALATQEHVNLSIRGNVKEVAARGANTCIISLKGLDDADDRFVLPEVNPALAPL VSVVPLQLIAYYAALHRGCDVDKPRNLAKSVTVE*" /label="glmS CDS" gene 199876..201678 /gene="glmS" /locus_tag="BSU_01780" /old_locus_tag="BSU01780" /label="glmS gene" S_feature complement(201401..>201681) /Source="Nicolas_S_feature" /locus_tag="new_201802_202546_c" /HighExp="S8, S7, S6, S5, S4, BC, S3, Sw, C30, LoTm" /AntisenseName="glmS" /AntisenseCor="4.5056549205256403E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.963" /TUlongSig="NA" /TUlongPSig="NA" /label="S70" downshifts 201664 /Source="Nicolas_upshifts" /id="D65" /incds=0 /nref=260 /ntot=277 /MaxReadThrough="3.18134" /MaxDrop="7.61794" /score="13.5044076" /energy="-17.5" /TU="NA" /idTUdmin="U122" /TUdmin=2 /isTUend="TRUE" /label="downshifts" SCAR join(201681,201727) /created_by="User" /note="deletion occured in betwen marked nucleotides" /modified_by="User" /label="Delta4" N_region 201682..201726 /note="insertion of 45 bases of unknown origin" /modified_by="User" /label="Delta4" S_feature <201727..201845 /Source="Nicolas_S_feature" /locus_tag="new_220105_220278" /HighExp="LoTm, T5.0H, T4.0H, T3.30H, Pyr, T-2.40H, T3.0H, T-5.40H, S2, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.984" /TUlongSig="NA" /TUlongPSig="NA" /label="S79" CDS 201846..202823 /gene="ybdG" /locus_tag="BSU_01990" /old_locus_tag="BSU01990" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase/transferase" /protein_id="NP_388081.2" /db_xref="EnsemblGenomes-Gn:BSU01990" /db_xref="EnsemblGenomes-Tr:CAB11993" /db_xref="GOA:O31431" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12722" /db_xref="UniProtKB/Swiss-Prot:O31431" /translation="MKTLWKVLKIVFVSLAALVLLVSVSVFIYHHFQLNKEAALLKGK GTVVDVDGKKMNVYQEGSGKDTFVFMSGSGIAAPAYEMKGLYSKFSKENKIAVVDRAG YGYSEVSHDDRDIDTVLEQTRKALMKSGNKPPYILMPHSISGIEAMYWAQKYPKEIKA IIAMDIGLPQQYVTYKLSGVDRLKVRGFHLLTSIGFHRFIPSAVYNPEVIRQSFLTDE EKEIYKAINFKQFFNADMEHELLQSYQNGSKSVNLPAPKETPVLILDAVSDQNRHSKY AIQNRKDYEAFAAQFNTADIKELRGTHSIYLYQPDQIYKLSMEFMRKVR*" /label="ybdG CDS" gene 201846..202823 /gene="ybdG" /locus_tag="BSU_01990" /old_locus_tag="BSU01990" /label="ybdG gene" CDS 202825..203496 /gene="ybdJ" /locus_tag="BSU_02000" /old_locus_tag="BSU02000" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 20035725" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 20035725; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component system response regulator [YbdK]" /protein_id="NP_388082.1" /db_xref="EnsemblGenomes-Gn:BSU02000" /db_xref="EnsemblGenomes-Tr:CAB11994" /db_xref="GOA:O31432" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12723" /db_xref="UniProtKB/Swiss-Prot:O31432" /translation="MKGYRILIVEDDVMIGDLLQKILQREGYRVIWKTDGADVLSVIQ KVDLVIMDVMLPGEDGYQMSAKIKKLGLGIPVIFLSARNDMDSKLQGLQIGEDYMVKP FDPRELLLRMRNMLEHHYGTFTQIKHLYIDAVTKKVFNESLHDEVLFTAIERKIFFYL YENRDSILTKEHFFEYLWQLEDRNPNIVNVHIKKIRAKINDQAGEMIENIYGEGYRLN TVVKK*" /label="ybdJ CDS" gene 202825..203496 /gene="ybdJ" /locus_tag="BSU_02000" /old_locus_tag="BSU02000" /label="ybdJ gene" promotor_-35 203390..203396 /Source="Nicolas_upshift_promotors" /id="U135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.929070929070929" /xcortree=2962 /SigmaFactorBS="gatagaaacccgaatattgtcaATGTGCAtattaaaaaaatt AGAGCTAAAATCAATGATCAagcgggtgagatgattgaaaatatatatggagaagggt a" /listShort="ybdK, ybzI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 203410..203429 /Source="Nicolas_upshift_promotors" /id="U135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.929070929070929" /xcortree=2962 /SigmaFactorBS="gatagaaacccgaatattgtcaATGTGCAtattaaaaaaatt AGAGCTAAAATCAATGATCAagcgggtgagatgattgaaaatatatatggagaagggt a" /listShort="ybdK, ybzI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 203428 /Source="Nicolas_upshifts" /id="U135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.929070929070929" /xcortree=2962 /SigmaFactorBS="gatagaaacccgaatattgtcaATGTGCAtattaaaaaaatt AGAGCTAAAATCAATGATCAagcgggtgagatgattgaaaatatatatggagaagggt a" /listShort="ybdK, ybzI" /GFF_Attribute="listLong" /label="upshifts" CDS 203517..204479 /gene="ybdK" /locus_tag="BSU_02010" /old_locus_tag="BSU02010" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 20035725" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 20035725; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component system sensor histidine kinase [YbdJ]" /protein_id="NP_388083.1" /db_xref="EnsemblGenomes-Gn:BSU02010" /db_xref="EnsemblGenomes-Tr:CAB11995" /db_xref="GOA:O31433" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12724" /db_xref="UniProtKB/Swiss-Prot:O31433" /translation="MLLFTAVISVPMLLLAVSVLMSVIYDSMFKPMNHGMPFHRSFAY PAMIVVFLISLLLLAFLFSKSIHSLLHKINLLNQTIRHLASDQRVPDKIEVKRADEIG ELIKSVNLLIERTTYRELELRQQEEIKKELLQKLRHDINTPLTALRLQLFYLEDQCHG QAVFESLYQQIEYISELTNEFNLYSAETLESSYIVNEEVRLNELLETAVKKWDYLYSM SGIELHYKPADQDVIWMSNTLWMERLFDNIFQNTLRHSKAKKMEVTIEHGDVFIRDDG IGFDRNESSEGLGLKIIEDTCRLLAITYELHTNDNGTGFLFSKE*" /label="ybdK CDS" gene 203517..204479 /gene="ybdK" /locus_tag="BSU_02010" /old_locus_tag="BSU02010" /label="ybdK gene" promotor_-35 204491..204493 /Source="Nicolas_upshift_promotors" /id="U136" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.866133866133866" /psig="0.999000999001" /xcortree=2204 /SigmaFactorBS="aacggggttcttgttttcaaaagagtgaccccgctgatgTTT ttctttctcctataaAATTTATATAATAGGGAGAAagaaatggggtgaacatcatatg t" /listShort="ybzI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 204509..204528 /Source="Nicolas_upshift_promotors" /id="U136" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.866133866133866" /psig="0.999000999001" /xcortree=2204 /SigmaFactorBS="aacggggttcttgttttcaaaagagtgaccccgctgatgTTT ttctttctcctataaAATTTATATAATAGGGAGAAagaaatggggtgaacatcatatg t" /listShort="ybzI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 204512 /Source="Nicolas_upshifts" /id="U136" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.866133866133866" /psig="0.999000999001" /xcortree=2204 /SigmaFactorBS="aacggggttcttgttttcaaaagagtgaccccgctgatgTTT ttctttctcctataaAATTTATATAATAGGGAGAAagaaatggggtgaacatcatatg t" /listShort="ybzI" /GFF_Attribute="listLong" /label="upshifts" CDS 204538..204801 /gene="ybzI" /locus_tag="BSU_02019" /old_locus_tag="BSU02019" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097672.1" /db_xref="EnsemblGenomes-Gn:BSU02019" /db_xref="EnsemblGenomes-Tr:CAX52542" /db_xref="UniProtKB/Swiss-Prot:C0H3T1" /translation="MNIICLKKSSKRLSTSQAVLVTDIADTGITAAAGADIIAATAAV RAKEDTTTVMAAVIVTNAGATAAVNPKKVLVPLLGQGFFYVTD*" /label="ybzI CDS" gene 204538..204801 /gene="ybzI" /locus_tag="BSU_02019" /old_locus_tag="BSU02019" /label="ybzI gene" downshifts 204742 /Source="Nicolas_upshifts" /id="D73" /incds=0 /nref=120 /ntot=235 /MaxReadThrough="2.82444" /MaxDrop="4.652" /score="22.3698707" /energy="-12.1" /TU="U135" /idTUdmin="U136" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" CDS complement(204786..205556) /gene="ybdM" /locus_tag="BSU_02030" /old_locus_tag="BSU02030" /EC_number="2.7.11.-" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 21304896; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative protein kinase" /protein_id="NP_388085.1" /db_xref="EnsemblGenomes-Gn:BSU02030" /db_xref="EnsemblGenomes-Tr:CAB11997" /db_xref="GOA:O31435" /db_xref="InterPro:IPR000719" /db_xref="InterPro:IPR011009" /db_xref="InterPro:IPR017441" /db_xref="SubtiList:BG12726" /db_xref="UniProtKB/Swiss-Prot:O31435" /translation="MALKLLKKLLFDRPLKNGVILNHQYKIEECLGMGGYGLVYLCTD ILAQTPYVLKQLRPTKAKKEKEKVRFQQEIKLLKNIHHPQIPGFIDEFIIDGQAYYVM QFIEGENIEELLFFRKQPFTELMALQLISQLLEIIEYLHDRLIFHSDIRTPNIIINDG RLCLIDFGLAKQLTPEEMEEIKVRKQDDFFDLGETLLFLLYSQYKGKKKKNGTWLEEL TLTKEVTLLLKRLLGIEEEYQHTASIREDLNRAIQSVT*" /label="ybdM CDS" gene complement(204786..205556) /gene="ybdM" /locus_tag="BSU_02030" /old_locus_tag="BSU02030" /label="ybdM gene" CDS complement(205642..206499) /gene="ybdN" /locus_tag="BSU_02040" /old_locus_tag="BSU02040" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16794953; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative phage protein; prophage region 1" /protein_id="NP_388086.1" /db_xref="EnsemblGenomes-Gn:BSU02040" /db_xref="EnsemblGenomes-Tr:CAB11998" /db_xref="SubtiList:BG12727" /db_xref="UniProtKB/Swiss-Prot:O31436" /translation="MVKKWLIQFAVMLSVLSTFTYSASAVGVTAITGNNSFDTAMPIG YWKYKNIDTTILEAGQDEAYFTFTANKGEKVYMRSTYQSAYTGMKIEIYDKNRIPVSQ GTEVINPNTFSSFIYANADAQNTTDTFYVKVSRGTYTGNMYFTLSIEDRIKSGSGTFQ FSGVAENKGNTSLSPSGSDSSVIKVDLTNQSGIPRDAIVTRVQTTATQTPSQGNTRHL IMTSENNEWSRALVNSSTSGSYDISLSDQLSVAKVWSFKYNTLATARSTMSNVKAKID YEYDVTKQF*" /label="ybdN CDS" gene complement(205642..206499) /gene="ybdN" /locus_tag="BSU_02040" /old_locus_tag="BSU02040" /label="ybdN gene" downshifts complement(205664) /Source="Nicolas_upshifts" /id="D74" /incds=0 /nref=95 /ntot=184 /MaxReadThrough="1.56932" /MaxDrop="4.95806" /score="36.4950689" /energy="-11.9" /TU="NA" /idTUdmin="U137" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(205713..205732) /Source="Nicolas_upshift_promotors" /id="U137" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1343 /SigmaFactorBS="ttgtaaacagctcgacttcagggtcttatgatatctctttgt cggatcaactcAGTGTGGCAAaggtatggagtttTAAATATAATACATTAGCGAcagc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(205746..205755) /Source="Nicolas_upshift_promotors" /id="U137" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1343 /SigmaFactorBS="ttgtaaacagctcgacttcagggtcttatgatatctctttgt cggatcaactcAGTGTGGCAAaggtatggagtttTAAATATAATACATTAGCGAcagc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(205748) /Source="Nicolas_upshifts" /id="U137" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1343 /SigmaFactorBS="ttgtaaacagctcgacttcagggtcttatgatatctctttgt cggatcaactcAGTGTGGCAAaggtatggagtttTAAATATAATACATTAGCGAcagc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(206512..206531) /Source="Nicolas_upshift_promotors" /id="U138" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2923 /SigmaFactorBS="ttttatcggcgaatataatgtatatattaacctcaaaaaaca ttTATTTACAcctaaatcgttattATGTATGATGGAAATAAAAGgaggttgtttgcat g" /listShort="ybdN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(206537) /Source="Nicolas_upshifts" /id="U138" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2923 /SigmaFactorBS="ttttatcggcgaatataatgtatatattaacctcaaaaaaca ttTATTTACAcctaaatcgttattATGTATGATGGAAATAAAAGgaggttgtttgcat g" /listShort="ybdN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(206546..206553) /Source="Nicolas_upshift_promotors" /id="U138" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2923 /SigmaFactorBS="ttttatcggcgaatataatgtatatattaacctcaaaaaaca ttTATTTACAcctaaatcgttattATGTATGATGGAAATAAAAGgaggttgtttgcat g" /listShort="ybdN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 206567..206574 /Source="Nicolas_upshift_promotors" /id="U139" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2834 /SigmaFactorBS="ataataacgatttaggtgtaaataaatgttttttgagGTTAA TATatacattatattcGCCGATAAAAAAGAATAAGagagaatactcgggagggaattc a" /listShort="ybdO" /listLong="S80, ybxG" /label="promotor_-35" promotor_-10 206588..206606 /Source="Nicolas_upshift_promotors" /id="U139" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2834 /SigmaFactorBS="ataataacgatttaggtgtaaataaatgttttttgagGTTAA TATatacattatattcGCCGATAAAAAAGAATAAGagagaatactcgggagggaattc a" /listShort="ybdO" /listLong="S80, ybxG" /label="promotor_-10" upshifts 206590 /Source="Nicolas_upshifts" /id="U139" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2834 /SigmaFactorBS="ataataacgatttaggtgtaaataaatgttttttgagGTTAA TATatacattatattcGCCGATAAAAAAGAATAAGagagaatactcgggagggaattc a" /listShort="ybdO" /listLong="S80, ybxG" /label="upshifts" CDS 206631..207815 /gene="ybdO" /locus_tag="BSU_02050" /old_locus_tag="BSU02050" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15033535; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative phage protein; prophage region 1" /protein_id="NP_388087.1" /db_xref="EnsemblGenomes-Gn:BSU02050" /db_xref="EnsemblGenomes-Tr:CAB11999" /db_xref="InterPro:IPR032617" /db_xref="SubtiList:BG12728" /db_xref="UniProtKB/Swiss-Prot:O31437" /translation="MRLNRQFIRTQLIAQNILSKNAPAKRENATENPAAVLEKAYSRL KSQSSTGGINQFNYSKTSVSGNSGTFSKVYQSANDRTVTDTGEETVIQSQNPYESESD IRIKILDEKYSRMNAINKTKSDPLGYIKDKYQNSKSPYFRSDLSAAERQAAYDNETEW LFKGKAQNYNLQDAVFRNVTFHGEVEAENEKVYQRGQVNQQLQVLLNRNHIHIPEGTE LTFTITPIDYQVRVSGTDDQDLIKQIEQVLQSGDNSKELFLHIMKSQSSDSAQFSEEA YKKYQAAREMYEVTGYHLKDLEVIDGRYVTPEGRDLMDVYKEELEKDPVQKQTASYAI SYYRSELSKIAEAGYNAIPDFILSIDYSNGSLRDVGQSKSYGTGDTGWLEALKRQTGV NY*" /label="ybdO CDS" gene 206631..207815 /gene="ybdO" /locus_tag="BSU_02050" /old_locus_tag="BSU02050" /label="ybdO gene" downshifts 207801 /Source="Nicolas_upshifts" /id="D75" /incds=0 /nref=107 /ntot=207 /MaxReadThrough="2.98334" /MaxDrop="4.9582" /score="-3.87053033" /energy="-8.3" /TU="U139" /idTUdmin="U139" /TUdmin="-181" /isTUend="FALSE" /label="downshifts" promotor_-35 207969..207975 /Source="Nicolas_upshift_promotors" /id="U140" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.430569430569431" /psig="0.999000999001" /xcortree=2998 /SigmaFactorBS="aacaaaggtgtttacctgaaaaaaacAATTGTAttttccaga gaaaTTTATTATGATGAAATAAGTaatttaggagattatataacaattttaagtttga a" /listShort="S80, ybxG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 207989..208008 /Source="Nicolas_upshift_promotors" /id="U140" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.430569430569431" /psig="0.999000999001" /xcortree=2998 /SigmaFactorBS="aacaaaggtgtttacctgaaaaaaacAATTGTAttttccaga gaaaTTTATTATGATGAAATAAGTaatttaggagattatataacaattttaagtttga a" /listShort="S80, ybxG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 208003..208132 /Source="Nicolas_S_feature" /locus_tag="new_226436_226565" /HighExp="Glu, LoTm, M9-stat, G135, GM-0.2, T-0.40H, Fru, UNK1, MG 120, GM-0.1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigD" /TUlongPSig=1 /label="S80" upshifts 208003 /Source="Nicolas_upshifts" /id="U140" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.430569430569431" /psig="0.999000999001" /xcortree=2998 /SigmaFactorBS="aacaaaggtgtttacctgaaaaaaacAATTGTAttttccaga gaaaTTTATTATGATGAAATAAGTaatttaggagattatataacaattttaagtttga a" /listShort="S80, ybxG" /GFF_Attribute="listLong" /label="upshifts" CDS 208133..209521 /gene="ybxG" /locus_tag="BSU_02060" /old_locus_tag="BSU02060" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative amino acid permease" /protein_id="NP_388088.1" /db_xref="EnsemblGenomes-Gn:BSU02060" /db_xref="EnsemblGenomes-Tr:CAB12000" /db_xref="GOA:P54425" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG11505" /db_xref="UniProtKB/Swiss-Prot:P54425" /translation="MANKELKRGLGARHIQMIALGGTIGVGLFMGSASTISWTGPSVL LAYAICGIFIFFIMRAMGEMLYVEPSTGSFATFGHQYIHPMAGYITAWSNWFQWIIVG MSEIIAVGSYTKYWFPDLPAWIPGIVAMVILGAANLISVKSFGEFEFWFAMIKIVTII LMIIAGIGIIFFGFGNGGDAIGLSNLWSHGGFFAGGFSGFFFALSLVIAAYQGVELIG ITAGEAKDPQNTLRNAIQSIIWRILIFYIGAIFVIVTVYPWDELNSLGSPFVSTFSKI GITAAAGIINFVVITAAMSGCNSGIFSAGRMLYTLGVNGQAPKFFKKISRNGVPLYGT IAVLIGLAVGVVLNYIAPPKIFVYVYSASVLPGMIPWFIILISHIGFRKAKGAALDKH PFKMPFAPFTNYLTIAFLLMVLVGMWFNDDTRISLIVGVIFLALVVISYYVFGIGKRT QANLTKSEQAAE*" /label="ybxG CDS" gene 208133..209521 /gene="ybxG" /locus_tag="BSU_02060" /old_locus_tag="BSU02060" /label="ybxG gene" downshifts 209529 /Source="Nicolas_upshifts" /id="D76" /incds=0 /nref=121 /ntot=219 /MaxReadThrough="2.32902" /MaxDrop="5.72049" /score="28.6554212" /energy="-8.5" /TU="NA" /idTUdmin="U140" /TUdmin="-15" /isTUend="TRUE" /label="downshifts" promotor_-35 209567..209573 /Source="Nicolas_upshift_promotors" /id="U141" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=938 /SigmaFactorBS="aaaagagacattcacggatgtctctttttttatttttcgCGT ATGGattttccctatttTAGCAAGCTATAgggtaaagatagcagaaggaaaggtgttc a" /listShort="csgA, ybxH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 209587..209598 /Source="Nicolas_upshift_promotors" /id="U141" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=938 /SigmaFactorBS="aaaagagacattcacggatgtctctttttttatttttcgCGT ATGGattttccctatttTAGCAAGCTATAgggtaaagatagcagaaggaaaggtgttc a" /listShort="csgA, ybxH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 209588 /Source="Nicolas_upshifts" /id="U141" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=938 /SigmaFactorBS="aaaagagacattcacggatgtctctttttttatttttcgCGT ATGGattttccctatttTAGCAAGCTATAgggtaaagatagcagaaggaaaggtgttc a" /listShort="csgA, ybxH" /GFF_Attribute="listLong" /label="upshifts" CDS 209633..209881 /gene="csgA" /locus_tag="BSU_02070" /old_locus_tag="BSU02070" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9016963" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9016963; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="sporulation-specific SASP protein" /protein_id="NP_388089.1" /db_xref="EnsemblGenomes-Gn:BSU02070" /db_xref="EnsemblGenomes-Tr:CAB12001" /db_xref="GOA:P54379" /db_xref="InterPro:IPR020255" /db_xref="SubtiList:BG11504" /db_xref="UniProtKB/Swiss-Prot:P54379" /translation="MDVTLGYLRESLSNHLENEVCQRICKKMLAKRYANEEEFVKDLD DNEMSFLNHVLEKEIKYAQNEQDQKRAKELNEVYELLL*" /label="csgA CDS" gene 209633..209881 /gene="csgA" /locus_tag="BSU_02070" /old_locus_tag="BSU02070" /label="csgA gene" CDS 209898..210089 /gene="ybxH" /locus_tag="BSU_02080" /old_locus_tag="BSU02080" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388090.1" /db_xref="EnsemblGenomes-Gn:BSU02080" /db_xref="EnsemblGenomes-Tr:CAB12002" /db_xref="InterPro:IPR035314" /db_xref="SubtiList:BG11506" /db_xref="UniProtKB/Swiss-Prot:P54426" /translation="MGAIERSGYTFQPEFSVVRQNGAIHVYHQGEFVEEIEFEFNGEY PDHDLIEELVNHYCFEHEI*" /label="ybxH CDS" gene 209898..210089 /gene="ybxH" /locus_tag="BSU_02080" /old_locus_tag="BSU02080" /label="ybxH gene" downshifts 210071 /Source="Nicolas_upshifts" /id="D77" /incds=0 /nref=17 /ntot=40 /MaxReadThrough="0.194030000000001" /MaxDrop="4.779" /score="29.4617878" /energy="-15.6" /TU="NA" /idTUdmin="U141" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(210116..210919) /gene="ybxI" /locus_tag="BSU_02090" /old_locus_tag="BSU02090" /EC_number="3.5.2.6" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14742199" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14742199; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exported beta-lactamase" /protein_id="NP_388091.1" /db_xref="EnsemblGenomes-Gn:BSU02090" /db_xref="EnsemblGenomes-Tr:CAB12003" /db_xref="GOA:P54427" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR002137" /db_xref="InterPro:IPR012338" /db_xref="PDB:5E2F" /db_xref="SubtiList:BG11507" /db_xref="UniProtKB/Swiss-Prot:P54427" /translation="MKKWIYVVLVLSIAGIGGFSVHAASSAHEKHLNVSKMNVDDEFK DTDGTFILHDLQKDQTFVYNRKRANQRQTPQSTFKVVNALIGLQVKAVRDEYDVKRWD GVKREFESWNRDHTLGSAMRESAIWYYQALARDIGEERMKTWLHTLSYGNEDISGGID QFWLQSSLTISPLEQETFLEKLAKEELPFDKPVMKIVKRMMIQEEGDHYTLYGKTGTR LTDMGLGWFVGFIKTEHGSYVFVTNVDDSGTKAKNITVDILKKYGLITS*" /label="ybxI CDS" gene complement(210116..210919) /gene="ybxI" /locus_tag="BSU_02090" /old_locus_tag="BSU02090" /label="ybxI gene" promotor_-10 complement(210941..210959) /Source="Nicolas_upshift_promotors" /id="U142" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=3196 /SigmaFactorBS="accaaatttaagcgctttttgattattttttAAAGGAAGAac aaacgaaaGAGAGAAAAGGTAGTTAATcaaaacgaaggggagaacaaaatgaaaaaat g" /listShort="ybxI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(210949) /Source="Nicolas_upshifts" /id="U142" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=3196 /SigmaFactorBS="accaaatttaagcgctttttgattattttttAAAGGAAGAac aaacgaaaGAGAGAAAAGGTAGTTAATcaaaacgaaggggagaacaaaatgaaaaaat g" /listShort="ybxI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(210970..210978) /Source="Nicolas_upshift_promotors" /id="U142" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=3196 /SigmaFactorBS="accaaatttaagcgctttttgattattttttAAAGGAAGAac aaacgaaaGAGAGAAAAGGTAGTTAATcaaaacgaaggggagaacaaaatgaaaaaat g" /listShort="ybxI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 211033..211039 /Source="Nicolas_upshift_promotors" /id="U143" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=163 /SigmaFactorBS="taaatttggttttgcaaacaaatactgttactgGGTTTATag tcggaagataacGTGAAAATAGAGGGTAAAAaggaaggcagggtaagcggatgaatga g" /listShort="cypC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 211054..211072 /Source="Nicolas_upshift_promotors" /id="U143" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=163 /SigmaFactorBS="taaatttggttttgcaaacaaatactgttactgGGTTTATag tcggaagataacGTGAAAATAGAGGGTAAAAaggaaggcagggtaagcggatgaatga g" /listShort="cypC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 211060 /Source="Nicolas_upshifts" /id="U143" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=163 /SigmaFactorBS="taaatttggttttgcaaacaaatactgttactgGGTTTATag tcggaagataacGTGAAAATAGAGGGTAAAAaggaaggcagggtaagcggatgaatga g" /listShort="cypC" /GFF_Attribute="listLong" /label="upshifts" CDS 211092..212345 /gene="cypC" /locus_tag="BSU_02100" /old_locus_tag="BSU02100" /EC_number="1.11.2.4" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10529095, 12519760, 21673922" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10529095, 12519760, 21673922; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fatty acid beta-hydroxylating cytochrome P450" /protein_id="NP_388092.1" /db_xref="EnsemblGenomes-Gn:BSU02100" /db_xref="EnsemblGenomes-Tr:CAB12004" /db_xref="GOA:O31440" /db_xref="InterPro:IPR001128" /db_xref="InterPro:IPR002401" /db_xref="InterPro:IPR036396" /db_xref="PDB:1IZO" /db_xref="PDB:2ZQJ" /db_xref="PDB:2ZQX" /db_xref="SubtiList:BG12729" /db_xref="UniProtKB/Swiss-Prot:O31440" /translation="MNEQIPHDKSLDNSLTLLKEGYLFIKNRTERYNSDLFQARLLGK NFICMTGAEAAKVFYDTDRFQRQNALPKRVQKSLFGVNAIQGMDGSAHIHRKMLFLSL MTPPHQKRLAELMTEEWKAAVTRWEKADEVVLFEEAKEILCRVACYWAGVPLKETEVK ERADDFIDMVDAFGAVGPRHWKGRRARPRAEEWIEVMIEDARAGLLKTTSGTALHEMA FHTQEDGSQLDSRMAAIELINVLRPIVAISYFLVFSALALHEHPKYKEWLRSGNSRER EMFVQEVRRYYPFGPFLGALVKKDFVWNNCEFKKGTSVLLDLYGTNHDPRLWDHPDEF RPERFAEREENLFDMIPQGGGHAEKGHRCPGEGITIEVMKASLDFLVHQIEYDVPEQS LHYSLARMPSLPESGFVMSGIRRKS*" /label="cypC CDS" gene 211092..212345 /gene="cypC" /locus_tag="BSU_02100" /old_locus_tag="BSU02100" /label="cypC gene" misc_feature 211404..211411 /Source="Nicolas_upshift_promotors" /id="U144" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.454545454545455" /psig="0.013986013986014" /xcortree=116 /SigmaFactorBS="atggcagcgcgcatatccatcggaagatgctttttctgtcat tgatgacaCCGCCGCAtcaaaaacgtttggctgagttgatgacagaggagtggaaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 211414 /Source="Nicolas_upshifts" /id="U144" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.454545454545455" /psig="0.013986013986014" /xcortree=116 /SigmaFactorBS="atggcagcgcgcatatccatcggaagatgctttttctgtcat tgatgacaCCGCCGCAtcaaaaacgtttggctgagttgatgacagaggagtggaaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 212338 /Source="Nicolas_upshifts" /id="D78" /incds=0 /nref=5 /ntot=36 /MaxReadThrough="2.65245" /MaxDrop="6.12325" /score="-7.42298703" /energy="-14.7" /TU="NA" /idTUdmin="U143" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(212386..212646) /gene="ybyB" /locus_tag="BSU_02110" /old_locus_tag="BSU02110" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388093.1" /db_xref="EnsemblGenomes-Gn:BSU02110" /db_xref="EnsemblGenomes-Tr:CAB12005" /db_xref="SubtiList:BG12754" /db_xref="UniProtKB/Swiss-Prot:O31441" /translation="MKQKLLLSGLAVSTVGITSYLLKDPSNRQKAREFIHSMKMKITK QPDMETFPVDKAGHPDPQDIEDNKMVSEGSMYPVQYYDEKKK*" /label="ybyB CDS" gene complement(212386..212646) /gene="ybyB" /locus_tag="BSU_02110" /old_locus_tag="BSU02110" /label="ybyB gene" downshifts complement(212405) /Source="Nicolas_upshifts" /id="D79" /incds=0 /nref=155 /ntot=247 /MaxReadThrough="3.63752" /MaxDrop="7.83539" /score="8.86703843" /energy="-12.4" /TU="U145" /idTUdmin="U145" /TUdmin="-387" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(212676..212694) /Source="Nicolas_upshift_promotors" /id="U145" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=227 /SigmaFactorBS="tactgttaattccaatgataaaaacacaacaGGTTTAGcaat ttccaaaacGGGAATGATACAGGAAACActattcttaaaatagaaaggagtatcacca t" /listShort="ybyB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(212685) /Source="Nicolas_upshifts" /id="U145" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=227 /SigmaFactorBS="tactgttaattccaatgataaaaacacaacaGGTTTAGcaat ttccaaaacGGGAATGATACAGGAAACActattcttaaaatagaaaggagtatcacca t" /listShort="ybyB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(212708..212714) /Source="Nicolas_upshift_promotors" /id="U145" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=227 /SigmaFactorBS="tactgttaattccaatgataaaaacacaacaGGTTTAGcaat ttccaaaacGGGAATGATACAGGAAACActattcttaaaatagaaaggagtatcacca t" /listShort="ybyB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 212838..212845 /Source="Nicolas_upshift_promotors" /id="U146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2207 /SigmaFactorBS="atatacattgacttattatagatttcagtcaaaattcgataa aTATTGACAaagtaaagtaatcagAATAATAATATAATTAGCAAgagaatgtcatcat a" /listShort="ybeC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 212855 /Source="Nicolas_upshifts" /id="U146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2207 /SigmaFactorBS="atatacattgacttattatagatttcagtcaaaattcgataa aTATTGACAaagtaaagtaatcagAATAATAATATAATTAGCAAgagaatgtcatcat a" /listShort="ybeC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 212861..212880 /Source="Nicolas_upshift_promotors" /id="U146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2207 /SigmaFactorBS="atatacattgacttattatagatttcagtcaaaattcgataa aTATTGACAaagtaaagtaatcagAATAATAATATAATTAGCAAgagaatgtcatcat a" /listShort="ybeC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 212915..214534 /gene="ybeC" /locus_tag="BSU_02120" /old_locus_tag="BSU02120" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative H+/amino acid transporter" /protein_id="NP_388094.2" /db_xref="EnsemblGenomes-Gn:BSU02120" /db_xref="EnsemblGenomes-Tr:CAB12006" /db_xref="GOA:Q45577" /db_xref="InterPro:IPR002293" /db_xref="SubtiList:BG12730" /db_xref="UniProtKB/Swiss-Prot:Q45577" /translation="MNQLHRRMGTFSLMMVGLGSMIGSGWLFGAWRAAQIAGPAAIIS WVIGMVVILFIALSYSELGSMFPEAGGMVKYTQYSHGSFIGFIAGWANWIAIVSVIPV EAVASVQYMSSWPWEWAKWTSGLVKNGTLTGEGLAFASVLLLIYFLLNYWTVNLFSKA NSLITIFKIIIPGLTIGALLFVGFHGENFTGGQSIAPNGWASVLTAVATSGIVFAFNG FQSPINMAGEAKNPGKSIPIAVVGSLFVATVIYVLLQIAFIGAVNPSDIAHGWSHLNF NSPFADLAIALNINWLVIVLYADAFVSPSGTGITYTATTSRMIYGMEKNKYMPSIFGK LHPIYGVPRQAMFFNLIVSFIFLFLFRGWGVLAEIISVATLISYITGPITVMTLRRTG KDLYRPLRLKGLNVIAPLGFIFASLVLYWARWPLTGQVLFIILIGLPIYFYYQAKAKW KGFGRNFKAGVWMVFYLLAMMVISYLGSDKFGGLNVIHYGWDMVLIAMVSLVFYVWAL KSGYQTEYLKDAKEINSQLLNGQSEAAAGKE*" /label="ybeC CDS" gene 212915..214534 /gene="ybeC" /locus_tag="BSU_02120" /old_locus_tag="BSU02120" /label="ybeC gene" downshifts 214517 /Source="Nicolas_upshifts" /id="D80" /incds=0 /nref=183 /ntot=273 /MaxReadThrough="0.8051" /MaxDrop="6.79949" /score="24.7668372" /energy="-12.2" /TU="NA" /idTUdmin="U146" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" CDS complement(214581..215462) /gene="glpQA" /locus_tag="BSU_02130" /old_locus_tag="BSU02130" /EC_number="3.1.4.46" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10913081, 21966272" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10913081, 21966272; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="secreted glycerophosphoryl diester phosphodiesterase" /protein_id="NP_388095.1" /db_xref="EnsemblGenomes-Gn:BSU02130" /db_xref="EnsemblGenomes-Tr:CAB12007" /db_xref="GOA:P37965" /db_xref="InterPro:IPR004129" /db_xref="InterPro:IPR017946" /db_xref="InterPro:IPR030395" /db_xref="PDB:5T91" /db_xref="PDB:5T9B" /db_xref="PDB:5T9C" /db_xref="SubtiList:BG10646" /db_xref="UniProtKB/Swiss-Prot:P37965" /translation="MRKNRILALFVLSLGLLSFMVTPVSAASKGNLLSPDRILTVAHR GASGYVPEHTILSYETAQKMKADFIELDLQMTKDGKLIVMHDEKLDRTTNGMGWVKDH TLADIKKLDAGSWFNEAYPEKAKPQYVGLKVPTLEEVLDRFGKHANYYIETKSPDTYP GMEEKLIASLQKHKLLGKHSKPGQVIIQSFSKESLVKVHQLQPNLPTVQLLEAKQMAS MTDAALEEIKTYAVGAGPDYKALNQENVRMIRSHGLLLHPYTVNNEADMHRLLDWGVT GVFTNYPDLFHKVKKGY*" /label="glpQA CDS" gene complement(214581..215462) /gene="glpQA" /locus_tag="BSU_02130" /old_locus_tag="BSU02130" /label="glpQA gene" downshifts complement(214592) /Source="Nicolas_upshifts" /id="D81" /incds=0 /nref=61 /ntot=107 /MaxReadThrough="2.31368" /MaxDrop="7.76277" /score="9.56390732" /energy="-11.4" /TU="NA" /idTUdmin="U147" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts complement(215505) /Source="Nicolas_upshifts" /id="U147" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.738261738261738" /psig="0.0999000999001" /xcortree=4 /SigmaFactorBS="tttaagaaagacacataaaaGATTAATagttttccAACACGC CGTTTACATCcgttttttattatgaaagacaggtagtgcttatctataaggaggagaa a" /listShort="glpQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(215514..215530) /Source="Nicolas_upshift_promotors" /id="U147" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.738261738261738" /psig="0.0999000999001" /xcortree=4 /SigmaFactorBS="tttaagaaagacacataaaaGATTAATagttttccAACACGC CGTTTACATCcgttttttattatgaaagacaggtagtgcttatctataaggaggagaa a" /listShort="glpQ" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(215539..215545) /Source="Nicolas_upshift_promotors" /id="U147" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.738261738261738" /psig="0.0999000999001" /xcortree=4 /SigmaFactorBS="tttaagaaagacacataaaaGATTAATagttttccAACACGC CGTTTACATCcgttttttattatgaaagacaggtagtgcttatctataaggaggagaa a" /listShort="glpQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(215561..216895) /gene="glpT" /locus_tag="BSU_02140" /old_locus_tag="BSU02140" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8012593, 11929549, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8012593, 11929549, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="sn-glycerol-3-phosphate permease" /protein_id="NP_388096.1" /db_xref="EnsemblGenomes-Gn:BSU02140" /db_xref="EnsemblGenomes-Tr:CAB12008" /db_xref="GOA:P37948" /db_xref="InterPro:IPR000849" /db_xref="InterPro:IPR005267" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR021159" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10645" /db_xref="UniProtKB/Swiss-Prot:P37948" /translation="MLNIFKPAPHIERLDDSKMDAAYKRLRLQVFIGIFIGYAGYYLL RKNFAFAIPYLQEQGFSKTELGLVLAAVSIAYGFSKFIMGMVSDRCNPRYFLATGLFL SAIVNILFVSMPWVTSSVTIMFIFMFINGWFQGMGWPPCGRTMAHWFSISERGTKMSI WNVAHNIGGGILAPLVTLGIAMFVTWKSVFFFPAIIAIIISFLIVLLVRDTPQSCGLP PIEEYRNDYPKHAFKNQEKELTTKEILFQYVLNNKFLWYIAFANVFVYFVRYGVVDWA PTYLTEAKGFSPEDSRWSYFLYEYAGIPGTILCGWISDRFFKSRRAPAGVLFMAGVFI AVLVYWLNPAGNPLVDNIALISIGFLIYGPVMLIGLQAIDLAPKKAAGTAAGLTGFFG YIGGSAFANAIMGFVVDRFNWNGGFIMLISSCILAIVFLALTWNTGKRAEHV*" /label="glpT CDS" gene complement(215561..216895) /gene="glpT" /locus_tag="BSU_02140" /old_locus_tag="BSU02140" /label="glpT gene" promotor_-35 216543..216552 /Source="Nicolas_upshift_promotors" /id="U148" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1339 /SigmaFactorBS="cgttgataaacataaaaataaacatgatggtgacgctcGAAG TCACCCaaggcattgaaaCGAATAGAATATTAACGATTgctgataaaaataggcctgt c" /listShort="S81, ybeF, ybfA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 216565..217191 /Source="Nicolas_S_feature" /locus_tag="new_234998_235624" /HighExp="S6, S8, S7, S5, BT, B36, G/S, C30, Pyr, B60" /AntisenseName="glpT" /AntisenseCor="-5.0958691169636701E-2" /AntisenseRegPval="-0.4" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S81" promotor_-10 216565..216584 /Source="Nicolas_upshift_promotors" /id="U148" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1339 /SigmaFactorBS="cgttgataaacataaaaataaacatgatggtgacgctcGAAG TCACCCaaggcattgaaaCGAATAGAATATTAACGATTgctgataaaaataggcctgt c" /listShort="S81, ybeF, ybfA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 216565 /Source="Nicolas_upshifts" /id="U148" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1339 /SigmaFactorBS="cgttgataaacataaaaataaacatgatggtgacgctcGAAG TCACCCaaggcattgaaaCGAATAGAATATTAACGATTgctgataaaaataggcctgt c" /listShort="S81, ybeF, ybfA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(216896..216968) /Source="Nicolas_S_feature" /locus_tag="new_235329_235401_c" /HighExp="G150, Oxctl, Paraq, S0, Diami, H2O2, Lbexp, dia5, dia0, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.042, 0.935" /TUlongSig="NA" /TUlongPSig="NA" /label="S82" promotor_no_box complement(216928..217028) /Source="Nicolas_upshift_promotors" /id="U149" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.370629370629371" /psig="0.041958041958042" /xcortree=1566 /SigmaFactorBS="tagcttggatggagatgaggagagccaggaatccaacccctt ttgacaaggggtgttttctggctctttttgtttttcgggaaaggaggcacgccacaca t" /listShort="S82, glpT, glpQ" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(216968) /Source="Nicolas_upshifts" /id="U149" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.370629370629371" /psig="0.041958041958042" /xcortree=1566 /SigmaFactorBS="tagcttggatggagatgaggagagccaggaatccaacccctt ttgacaaggggtgttttctggctctttttgtttttcgggaaaggaggcacgccacaca t" /listShort="S82, glpT, glpQ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(216970..217056) /Source="Nicolas_S_feature" /locus_tag="new_235403_235489_c" /HighExp="G150, Oxctl, S0, Diami, Lbexp, dia5, Paraq, dia0, T0.30H, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.935" /TUlongSig="NA" /TUlongPSig="NA" /label="S83" promotor_-10 complement(217046..217065) /Source="Nicolas_upshift_promotors" /id="U150" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.396603396603397" /psig="0.935064935064935" /xcortree=1567 /SigmaFactorBS="tattcacttccctaaggcccaatttgaaaattaccCGTTTAC AttcgctccggacTATGATAATTTAAGAAAGCGctatcatgataagttaatagcttgg a" /listShort="S83, S82, glpT, glpQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(217060) /Source="Nicolas_upshifts" /id="U150" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.396603396603397" /psig="0.935064935064935" /xcortree=1567 /SigmaFactorBS="tattcacttccctaaggcccaatttgaaaattaccCGTTTAC AttcgctccggacTATGATAATTTAAGAAAGCGctatcatgataagttaatagcttgg a" /listShort="S83, S82, glpT, glpQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(217078..217085) /Source="Nicolas_upshift_promotors" /id="U150" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.396603396603397" /psig="0.935064935064935" /xcortree=1567 /SigmaFactorBS="tattcacttccctaaggcccaatttgaaaattaccCGTTTAC AttcgctccggacTATGATAATTTAAGAAAGCGctatcatgataagttaatagcttgg a" /listShort="S83, S82, glpT, glpQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS 217192..217440 /gene="ybeF" /locus_tag="BSU_02150" /old_locus_tag="BSU02150" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388097.1" /db_xref="EnsemblGenomes-Gn:BSU02150" /db_xref="EnsemblGenomes-Tr:CAB12009" /db_xref="GOA:O31442" /db_xref="InterPro:IPR020258" /db_xref="SubtiList:BG12731" /db_xref="UniProtKB/Swiss-Prot:O31442" /translation="MDELDIAFFILPLGIMLLSIVGTCICKNPYLMPMLSLVISLVLT FTIFNQSFLGWAVVYSLVSLALSYITLIVVRKRKESGN*" /label="ybeF CDS" gene 217192..217440 /gene="ybeF" /locus_tag="BSU_02150" /old_locus_tag="BSU02150" /label="ybeF gene" promotor_-35 217464..217471 /Source="Nicolas_upshift_promotors" /id="U151" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.801198801198801" /psig="0.984015984015984" /xcortree=3080 /SigmaFactorBS="gtaaggaaaaggaaggaatcaggaaattaaaaagacctcact ttctaacatatCGTTGACTaaagcaactatatgtGATTATAATTGCTTTAGTCAacga t" /listShort="ybfA, ybfB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 217471 /Source="Nicolas_upshifts" /id="U151" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.801198801198801" /psig="0.984015984015984" /xcortree=3080 /SigmaFactorBS="gtaaggaaaaggaaggaatcaggaaattaaaaagacctcact ttctaacatatCGTTGACTaaagcaactatatgtGATTATAATTGCTTTAGTCAacga t" /listShort="ybfA, ybfB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 217487..217506 /Source="Nicolas_upshift_promotors" /id="U151" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.801198801198801" /psig="0.984015984015984" /xcortree=3080 /SigmaFactorBS="gtaaggaaaaggaaggaatcaggaaattaaaaagacctcact ttctaacatatCGTTGACTaaagcaactatatgtGATTATAATTGCTTTAGTCAacga t" /listShort="ybfA, ybfB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 217532..218449 /gene="ybfA" /locus_tag="BSU_02160" /old_locus_tag="BSU02160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator with acetyltransferase domain" /protein_id="NP_388098.1" /db_xref="EnsemblGenomes-Gn:BSU02160" /db_xref="EnsemblGenomes-Tr:CAB12010" /db_xref="GOA:O31443" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12732" /db_xref="UniProtKB/Swiss-Prot:O31443" /translation="MKTRESSVGLKFRKFNRFYTNVLGFLNEHIYDSPFSLTETRILF EIYNTPNCTAKALQDKLGLDRGYVSRIVKQFEKEDLIYKQRSKDDARHHYIFVTETGK TIYKKLEEKANEQVELMLKVINQKEQHKLAEAMAEIEAILSQSLSARASEISIRDYFL SEDLQLLIEKQRQFYAEAHGWDDTFLAYLQETFDADIEKIWIAESGGKFAGSVGLVKH DEKTVQLRWFLVDADFRGRGLGTQLLEHLVAYCQDMKFDRIFLWTVSTMAEARPLYKK FGFRISEVKQEAPLWGQQLTEERWDLELS*" /label="ybfA CDS" gene 217532..218449 /gene="ybfA" /locus_tag="BSU_02160" /old_locus_tag="BSU02160" /label="ybfA gene" CDS 218446..219696 /gene="ybfB" /locus_tag="BSU_02170" /old_locus_tag="BSU02170" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative carboxylate transporter" /protein_id="NP_388099.1" /db_xref="EnsemblGenomes-Gn:BSU02170" /db_xref="EnsemblGenomes-Tr:CAB12011" /db_xref="GOA:O31444" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12733" /db_xref="UniProtKB/Swiss-Prot:O31444" /translation="MKRLHYAWIIVSVTFLILLAVQGVRLSFGAFVEPWERQFSIDRS TISLISTVSFIVYGISQPVIGRLVDKWGARAVLAWSALLTGVSIFLTYLVTSPWQLFL LYGLGVSLGVGGASNVAASVLVVNWFSKKRGLAFGIMEAGFGAGQMLLVPGSLMLIHW FSWKLTVVVLGLLLIVIVFPAALLMLRNNPSEKNTEPIGGLAASEKETAPKTTALSVA GMFRMRQFWFLIFPFLICGFTTVGLMDTHLIPFSHDHGFSTTVTSAAVSLLAGFNIAG ILLSGIVADRWSSRKILCILYAVRALSIVILIYSHEPYLLLAFAILFGLVDFATVAPT QMLATQYFQNYSIGLMIGWLSLAHQIGSALGAYVPGVIYTVTGEYTLAFYLSIGMLVL ASVMNVMLREPAAVTRDSAAVVDK*" /label="ybfB CDS" gene 218446..219696 /gene="ybfB" /locus_tag="BSU_02170" /old_locus_tag="BSU02170" /label="ybfB gene" downshifts 219686 /Source="Nicolas_upshifts" /id="D82" /incds=0 /nref=57 /ntot=187 /MaxReadThrough="1.17226" /MaxDrop="5.55429" /score="12.1347284" /energy="-9.5" /TU="NA" /idTUdmin="U151" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(219731..220015) /gene="ybfEc" /locus_tag="BSU_02180" /old_locus_tag="BSU02180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (C-terminal end)" /db_xref="EnsemblGenomes-Gn:BSU02180" /db_xref="EnsemblGenomes-Tr:CAB12012" /db_xref="GOA:O31445" /db_xref="PSEUDO:CAB12012.2" /db_xref="SubtiList:BG12734" /db_xref="UniProtKB/Swiss-Prot:O31445" /translation="MNHCLHSNTLAKIVCTVTLITLYFYFFSTRFNELIELAVQMFFA LIGLFWVFIVSPFSRKVQISERFKQKSENARIVGMIDFVLEQKYKKSISE*" /label="ybfEc CDS" gene complement(219731..220015) /gene="ybfEc" /locus_tag="BSU_02180" /old_locus_tag="BSU02180" /pseudo /label="ybfEc gene" downshifts complement(219784) /Source="Nicolas_upshifts" /id="D83" /incds=0 /nref=4 /ntot=189 /MaxReadThrough="2.49989" /MaxDrop="3.7302" /score="13.7144473" /energy="-12.6" /TU="U153" /idTUdmin="U153" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(219921..220043) /gene="ybfEn" /locus_tag="BSU_02181" /old_locus_tag="BSU02181" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved protein of unknown function YbfE (N-terminal fragment)" /db_xref="PSEUDO:SOX90538.1" /translation="MLNQLKVFFSEPLLTFKHTCQNRMYCDINNVILLFFQHSF*" /label="ybfEn CDS" gene complement(219921..220043) /gene="ybfEn" /locus_tag="BSU_02181" /old_locus_tag="BSU02181" /pseudo /label="ybfEn gene" S_feature complement(220016..220136) /Source="Nicolas_S_feature" /locus_tag="new_238449_238569_c" /HighExp="Lbexp, dia0, LBGexp, G150, Mt0, H2O2, dia5, M0t45, G135, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, Sig-" /TUshortPSig="0.899, 0" /TUlongSig="NA" /TUlongPSig="NA" /label="S84" promotor_-10 complement(220121..220139) /Source="Nicolas_upshift_promotors" /id="U152" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.899100899100899" /psig="0.899100899100899" /xcortree=1463 /SigmaFactorBS="tactaagaaatactcaatttttatactttaagagaTGTATAt attgaatgtagaccaCCATACATATAAAGAAACAgaaacagcaactttattttagaac a" /listShort="S84, ybfE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(220136) /Source="Nicolas_upshifts" /id="U152" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.899100899100899" /psig="0.899100899100899" /xcortree=1463 /SigmaFactorBS="tactaagaaatactcaatttttatactttaagagaTGTATAt attgaatgtagaccaCCATACATATAAAGAAACAgaaacagcaactttattttagaac a" /listShort="S84, ybfE" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(220138..220210) /Source="Nicolas_S_feature" /locus_tag="new_238571_238643_c" /HighExp="Lbexp, dia0, LBGexp, HPh, G150, H2O2, dia5, Mt0, M0t45, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig=0 /TUlongSig="NA" /TUlongPSig="NA" /label="S85" promotor_-35 complement(220156..220161) /Source="Nicolas_upshift_promotors" /id="U152" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.899100899100899" /psig="0.899100899100899" /xcortree=1463 /SigmaFactorBS="tactaagaaatactcaatttttatactttaagagaTGTATAt attgaatgtagaccaCCATACATATAAAGAAACAgaaacagcaactttattttagaac a" /listShort="S84, ybfE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(220211..221122) /gene="ybfF" /locus_tag="BSU_02190" /old_locus_tag="BSU02190" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388101.1" /db_xref="EnsemblGenomes-Gn:BSU02190" /db_xref="EnsemblGenomes-Tr:CAB12013" /db_xref="GOA:O31446" /db_xref="SubtiList:BG12735" /db_xref="UniProtKB/Swiss-Prot:O31446" /translation="MKNDQIVFEKTKNIAHDINQMQNQQEIIDYLFRQDSLTLNQLKH YYSEPSLPLQFLVKVAVLCMFISMTLASFLFIQAKEVFTNTILSDISPAVFSIFTVIC IFMTYTKIIKKGNKNKGKASLNQRSEFYEKNKLINTILYKKYKMDQQNIQANKHTASD NEDSMNFSAVLNHVLTISKNDKELLGYLDTRDNAMLSQLKAYFSTRPFSLPHYMSLMF CGSIIVVYATSLFSGQINYIDIPHIFIFLLLIIFLKILIDLIKLLNISRKGQLHTVLH FAQRAEYLRMRGVIDFILTERYNKKIM*" /label="ybfF CDS" gene complement(220211..221122) /gene="ybfF" /locus_tag="BSU_02190" /old_locus_tag="BSU02190" /label="ybfF gene" S_feature complement(221123..221210) /Source="Nicolas_S_feature" /locus_tag="new_239556_239643_c" /HighExp="LBGexp, Lbexp, G150, dia5, dia0, G135, Oxctl, H2O2, Mt0, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig=0 /TUlongSig="NA" /TUlongPSig="NA" /label="S86" CDS complement(221211..223409) /gene="ybfG" /locus_tag="BSU_02200" /old_locus_tag="BSU02200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative pepdidoglycan binding protein" /protein_id="NP_388102.1" /db_xref="EnsemblGenomes-Gn:BSU02200" /db_xref="EnsemblGenomes-Tr:CAB12014" /db_xref="GOA:O31447" /db_xref="InterPro:IPR002477" /db_xref="InterPro:IPR015020" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR036365" /db_xref="InterPro:IPR036366" /db_xref="SubtiList:BG12736" /db_xref="UniProtKB/Swiss-Prot:O31447" /translation="MVDEMVLITQQWLNDTYSGKHGYNPVEESGKTGWDTIYGLTRAL QIELGISEPADNFGPTTQRLFKPLKRQAPDSKPSNMNFILQGALWCKGFNPGGFTGVF YEKTENAVKEFQKAAGLTTQDGIVTTLIMKALLDMSAFKLVSGGDSRIRQIQQNLNRD YNDYIGLMPCDGLYGRDTNKALIYALQKEEGMSTSVANGFFGNGTTSLCPTLTPGDSR TGFVLIVQYALYCNGKSFDPGEFDGKYGVGVVSAVKAFQEFMCLPQTGYADMPTIKAL LSSSGDTTRTASACDTATIITAEKAQTLRNNGYKTVGRYLTGNVRTSSGLTSKALTSK ELAVILDAGLKVFPIYQDGGYESSYFVKDQGTRDAYSAASAARRLGFPSGTTIYFAVD FDAYDYEVTDKIIPYFQEIKSAFTKMQTFSTAPKYEIGVYGPRNICIRTSEAGLTKYS FVANMSTGFSGNLGYPMPNNWAFDQFYEGTIGSGSGSIGIDKDGYSGRDSGASNVNPP SDPVYDARLRTLTDILSTIPALENLTSLANAMFEFDTTETIFTSPELDIILSTSLLAT IPSEGSPNTITITNGKPGAYITGLLGDTQTSLTASQIDSYQNLLNSLSLSVRNGYLEV YVNPTAESLNIQIKIYTPDIPVGDNVTTGLTTTITFKIKTYKGVPVTSPESELALDWP SYDQYLFPVVGVAALLLIGNMGSDLTNNKGVKVATALSAMLLAIFAYYTS*" /label="ybfG CDS" gene complement(221211..223409) /gene="ybfG" /locus_tag="BSU_02200" /old_locus_tag="BSU02200" /label="ybfG gene" misc_feature complement(223444..223462) /Source="Nicolas_upshift_promotors" /id="U153" /multdbtbs="-" /comp="M12" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=1523 /SigmaFactorBS="ctgttggagaacggatgtaaaatggatgcttaacggcatcca tttttttattttGTCCTACGTTTGCCACCTAtaaatgaacgcaatctaacaaaggagg a" /listShort="ybfG, S86, ybfF, S85, S84, ybfE" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(223456) /Source="Nicolas_upshifts" /id="U153" /multdbtbs="-" /comp="M12" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=1523 /SigmaFactorBS="ctgttggagaacggatgtaaaatggatgcttaacggcatcca tttttttattttGTCCTACGTTTGCCACCTAtaaatgaacgcaatctaacaaaggagg a" /listShort="ybfG, S86, ybfF, S85, S84, ybfE" /GFF_Attribute="listLong" /label="upshifts" CDS complement(223484..224404) /gene="ybfH" /locus_tag="BSU_02210" /old_locus_tag="BSU02210" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388103.1" /db_xref="EnsemblGenomes-Gn:BSU02210" /db_xref="EnsemblGenomes-Tr:CAB12015" /db_xref="GOA:O31448" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG12737" /db_xref="UniProtKB/Swiss-Prot:O31448" /translation="MNIQRETSGHIAAIVTILIWGTTFISTKVLLADFSPMEILFYRF LMGFIALILVRPNMIPFRNWRQELLFAGAGLFGVTLYFLLENIALTYTYASNVGMIVS IIPMITAVLAHFLLEGEKLRLTFLIGFISALIGLLLITFNGNVVLRLNPLGDIMAAGA ALVFGGYSIFMKKLSAYEYHIIELTQRVFLYGLLFMVPALFLFDFHFDLSRFSSASNI LNMLFLGIGASALCFATWNYSVGVLGAVKSSAYIYMVPVITIAASVLILHENMTWIAL LGGALTLLGLYISELKPKAKLLENGCKMDA*" /label="ybfH CDS" gene complement(223484..224404) /gene="ybfH" /locus_tag="BSU_02210" /old_locus_tag="BSU02210" /label="ybfH gene" CDS complement(224401..225228) /gene="ybfI" /locus_tag="BSU_02220" /old_locus_tag="BSU02220" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (AraC/XylS family, cupin family)" /protein_id="NP_388104.1" /db_xref="EnsemblGenomes-Gn:BSU02220" /db_xref="EnsemblGenomes-Tr:CAB12016" /db_xref="GOA:O31449" /db_xref="InterPro:IPR003313" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR018060" /db_xref="SubtiList:BG12738" /db_xref="UniProtKB/Swiss-Prot:O31449" /translation="MQNETRTLQLDPHLHIEAYRFKGIMQKFPNHFHDYYVIGFIEKG QRYLACQDQEYIINPGDLLLFNPRDTHSCEQIDGRTLDYRCINVMPDIMEKAVKEITG SGHLPYFSQHVLFRHELTASLQELHILISEEKQALRKEELFLHLLEELIRHYSDVTFL SSVPEPSDEVKMVCEFLEEHYAENVTLNDLSELTGWSKYHLLRSFTKQKGITPNSYME TIRINQAKKLLEQGVRPIDAAFQTGFSDQSHMTKFFKRQVGLTPKQYMKIFEKELHR* " /label="ybfI CDS" gene complement(224401..225228) /gene="ybfI" /locus_tag="BSU_02220" /old_locus_tag="BSU02220" /label="ybfI gene" misc_feature complement(225255..225274) /Source="Nicolas_upshift_promotors" /id="U154" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig="0.999000999001" /xcortree=583 /SigmaFactorBS="ctttctctattcctaaacagcaacatcatacaagaaatcccc caaaatCATGCTACACTTAATCCAAGaccaccacaccgacaggaggcatcccatgcaa a" /listShort="ybfI" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(225262) /Source="Nicolas_upshifts" /id="U154" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig="0.999000999001" /xcortree=583 /SigmaFactorBS="ctttctctattcctaaacagcaacatcatacaagaaatcccc caaaatCATGCTACACTTAATCCAAGaccaccacaccgacaggaggcatcccatgcaa a" /listShort="ybfI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 225402..225405 /Source="Nicolas_upshift_promotors" /id="U155" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.999000999001" /xcortree=2313 /SigmaFactorBS="tttaaccctcaataataattttatcttttttaataaaAATTt atttttcaaatatTTCAGTTATAATGGTTTGGAacagataggaggggcaaagatgtat c" /listShort="purT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 225420..225439 /Source="Nicolas_upshift_promotors" /id="U155" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.999000999001" /xcortree=2313 /SigmaFactorBS="tttaaccctcaataataattttatcttttttaataaaAATTt atttttcaaatatTTCAGTTATAATGGTTTGGAacagataggaggggcaaagatgtat c" /listShort="purT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 225425 /Source="Nicolas_upshifts" /id="U155" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.999000999001" /xcortree=2313 /SigmaFactorBS="tttaaccctcaataataattttatcttttttaataaaAATTt atttttcaaatatTTCAGTTATAATGGTTTGGAacagataggaggggcaaagatgtat c" /listShort="purT" /GFF_Attribute="listLong" /label="upshifts" CDS 225459..226613 /gene="purT" /locus_tag="BSU_02230" /old_locus_tag="BSU02230" /EC_number="2.1.2.-" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7496533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7496533; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylglycinamide formyltransferase 2" /protein_id="NP_388105.1" /db_xref="EnsemblGenomes-Gn:BSU02230" /db_xref="EnsemblGenomes-Tr:CAB12017" /db_xref="GOA:P39771" /db_xref="InterPro:IPR003135" /db_xref="InterPro:IPR005862" /db_xref="InterPro:IPR011054" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="SubtiList:BG10924" /db_xref="UniProtKB/Swiss-Prot:P39771" /translation="MYQSKKVLLLGSGELGKEVVIEAQRLGVQTVAVDSYEHAPAMQV AHNSYVVDMLDPEQIRTIIEKENPDLIVPEVEAIATDELLKLEEEGFHVIPNARAAKL TMDREGIRRLAAETLGLATAGYEFANTYDEFIQAAAQIGFPCVVKPLMSSSGKGQSVC RSEADLESCWETAMEGGRVKNGRVIVEEFIPFESEITLLTVRAVNGTAFCEPIGHVQK DGDYIESWQPHDMTEQQIEEAKHIAKTITDELGGYGLFGVELFLAKDRVYFSEVSPRP HDTGLVTLVTQNLSEFALHVRAILGFPITEITQLSPGASRPLKAPEELADYTVEGLEN ALAVPKTQVRVFGKPITKAGRRMAVALSAADSVETARENAKKALDQLILK*" /label="purT CDS" gene 225459..226613 /gene="purT" /locus_tag="BSU_02230" /old_locus_tag="BSU02230" /label="purT gene" downshifts 226594 /Source="Nicolas_upshifts" /id="D84" /incds=0 /nref=100 /ntot=189 /MaxReadThrough="2.6996" /MaxDrop="5.22319" /score="39.2561117" /energy="-15.1" /TU="NA" /idTUdmin="U155" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 226674..226679 /Source="Nicolas_upshift_promotors" /id="U156" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=1104 /SigmaFactorBS="ttgtcatgggacaaggcctgtttttttctttctccgtaaaag ttttATCATAagaatcagaaacctGATTATAATGTAAAAGTCTtccatcgatacgggt g" /listShort="mpr, ybfJ" /listLong="S87, ybfK, S88, pssA, ybfM, psd" /label="promotor_-35" upshifts 226688 /Source="Nicolas_upshifts" /id="U156" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=1104 /SigmaFactorBS="ttgtcatgggacaaggcctgtttttttctttctccgtaaaag ttttATCATAagaatcagaaacctGATTATAATGTAAAAGTCTtccatcgatacgggt g" /listShort="mpr, ybfJ" /listLong="S87, ybfK, S88, pssA, ybfM, psd" /label="upshifts" promotor_-10 226694..226712 /Source="Nicolas_upshift_promotors" /id="U156" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=1104 /SigmaFactorBS="ttgtcatgggacaaggcctgtttttttctttctccgtaaaag ttttATCATAagaatcagaaacctGATTATAATGTAAAAGTCTtccatcgatacgggt g" /listShort="mpr, ybfJ" /listLong="S87, ybfK, S88, pssA, ybfM, psd" /label="promotor_-10" promotor_-35 226728..226735 /Source="Nicolas_upshift_promotors" /id="U157" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.390609390609391" /psig=1 /xcortree=760 /SigmaFactorBS="acctgattataatgtaaaagtcttccatcgatacgggtGGTT GACActaaaggagggagaTGACAAAATGAAATTAGTTCcaagattcagaaaacaatgg t" /listShort="mpr, ybfJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 226750..226769 /Source="Nicolas_upshift_promotors" /id="U157" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.390609390609391" /psig=1 /xcortree=760 /SigmaFactorBS="acctgattataatgtaaaagtcttccatcgatacgggtGGTT GACActaaaggagggagaTGACAAAATGAAATTAGTTCcaagattcagaaaacaatgg t" /listShort="mpr, ybfJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 226750 /Source="Nicolas_upshifts" /id="U157" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.390609390609391" /psig=1 /xcortree=760 /SigmaFactorBS="acctgattataatgtaaaagtcttccatcgatacgggtGGTT GACActaaaggagggagaTGACAAAATGAAATTAGTTCcaagattcagaaaacaatgg t" /listShort="mpr, ybfJ" /GFF_Attribute="listLong" /label="upshifts" CDS 226757..227698 /gene="mpr" /locus_tag="BSU_02240" /old_locus_tag="BSU02240" /EC_number="3.4.21.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 15205417, 15375126, 21819557, 25666135; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="extracellular glutamyl-endopeptidase" /protein_id="NP_388106.1" /db_xref="EnsemblGenomes-Gn:BSU02240" /db_xref="EnsemblGenomes-Tr:CAB12018" /db_xref="GOA:P39790" /db_xref="InterPro:IPR000126" /db_xref="InterPro:IPR001254" /db_xref="InterPro:IPR008256" /db_xref="InterPro:IPR009003" /db_xref="InterPro:IPR018114" /db_xref="InterPro:IPR028301" /db_xref="SubtiList:BG10690" /db_xref="UniProtKB/Swiss-Prot:P39790" /translation="MKLVPRFRKQWFAYLTVLCLALAAAVSFGVPAKAAENPQTSVSN TGKEADATKNQTSKADQVSAPYEGTGKTSKSLYGGQTELEKNIQTLQPSSIIGTDERT RISSTTSFPYRATVQLSIKYPNTSSTYGCTGFLVNPNTVVTAGHCVYSQDHGWASTIT AAPGRNGSSYPYGTYSGTMFYSVKGWTESKDTNYDYGAIKLNGSPGNTVGWYGYRTTN SSSPVGLSSSVTGFPCDKTFGTMWSDTKPIRSAETYKLTYTTDTYGCQSGSPVYRNYS DTGQTAIAIHTNGGSSYNLGTRVTNDVFNNIQYWANQ*" /label="mpr CDS" gene 226757..227698 /gene="mpr" /locus_tag="BSU_02240" /old_locus_tag="BSU02240" /label="mpr gene" CDS 227661..228059 /gene="ybfJ" /locus_tag="BSU_02250" /old_locus_tag="BSU02250" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_388107.1" /db_xref="EnsemblGenomes-Gn:BSU02250" /db_xref="EnsemblGenomes-Tr:CAB12019" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR019730" /db_xref="SubtiList:BG12739" /db_xref="UniProtKB/Swiss-Prot:O31451" /translation="MYSTIFNIGQINKYSKLAIFMSILFLCGCSSQTHSSQKETTIPV TLHVEDAKGLPVEGVQVTIVKAPSSDEEPSTEIGEILGKTDKNGDIKWDTGRKGDYSV ALTKGETSVTHHISLTEDKKDHAIPLVFKE*" /label="ybfJ CDS" gene 227661..228059 /gene="ybfJ" /locus_tag="BSU_02250" /old_locus_tag="BSU02250" /label="ybfJ gene" promotor_-10 complement(227753..227767) /Source="Nicolas_upshift_promotors" /id="U158" /multdbtbs="-" /comp="M1" /sig="Sig-" /pcomp="0.418581418581419" /psig="0.418581418581419" /xcortree=776 /SigmaFactorBS="gcagccccttagcatcctccacatgaagagtgacaGGAATAg tcgtttctttttgaGAAGAATGCGTCTGCgaactgcacccgcataaaaacaaaataga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(227763) /Source="Nicolas_upshifts" /id="U158" /multdbtbs="-" /comp="M1" /sig="Sig-" /pcomp="0.418581418581419" /psig="0.418581418581419" /xcortree=776 /SigmaFactorBS="gcagccccttagcatcctccacatgaagagtgacaGGAATAg tcgtttctttttgaGAAGAATGCGTCTGCgaactgcacccgcataaaaacaaaataga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(227783..227788) /Source="Nicolas_upshift_promotors" /id="U158" /multdbtbs="-" /comp="M1" /sig="Sig-" /pcomp="0.418581418581419" /psig="0.418581418581419" /xcortree=776 /SigmaFactorBS="gcagccccttagcatcctccacatgaagagtgacaGGAATAg tcgtttctttttgaGAAGAATGCGTCTGCgaactgcacccgcataaaaacaaaataga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 228046 /Source="Nicolas_upshifts" /id="D85" /incds=0 /nref=19 /ntot=51 /MaxReadThrough="3.50775" /MaxDrop="5.06025" /score="29.4582027" /energy="-15.4" /TU="U156" /idTUdmin="U157" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 228115..228122 /Source="Nicolas_upshift_promotors" /id="U159" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.833166833166833" /psig=1 /xcortree=2185 /SigmaFactorBS="ttttatttattgcaggaaaccaaacTATATACTggaaattta ttatgTGAGATAATAAGAAATAGGTattttttcttacgagacaaaaggggcgttatcc t" /listShort="S87, ybfK, S88, pssA, ybfM, psd" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 228137..228156 /Source="Nicolas_upshift_promotors" /id="U159" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.833166833166833" /psig=1 /xcortree=2185 /SigmaFactorBS="ttttatttattgcaggaaaccaaacTATATACTggaaattta ttatgTGAGATAATAAGAAATAGGTattttttcttacgagacaaaaggggcgttatcc t" /listShort="S87, ybfK, S88, pssA, ybfM, psd" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 228150..228224 /Source="Nicolas_S_feature" /locus_tag="new_246583_246657" /HighExp="Cold, LoTm, S0, aero, ferm, T-4.40H, nit, T-5.40H, T-0.40H, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigEF" /TUlongPSig="0.973" /label="S87" upshifts 228150 /Source="Nicolas_upshifts" /id="U159" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.833166833166833" /psig=1 /xcortree=2185 /SigmaFactorBS="ttttatttattgcaggaaaccaaacTATATACTggaaattta ttatgTGAGATAATAAGAAATAGGTattttttcttacgagacaaaaggggcgttatcc t" /listShort="S87, ybfK, S88, pssA, ybfM, psd" /GFF_Attribute="listLong" /label="upshifts" CDS 228225..229115 /gene="cesB" /locus_tag="BSU_02260" /old_locus_tag="BSU02260" /EC_number="3.1.1.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11389736, 24418394" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11389736, 24418394; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enantioselective carboxylesterase" /protein_id="NP_388108.1" /db_xref="EnsemblGenomes-Gn:BSU02260" /db_xref="EnsemblGenomes-Tr:CAB12020" /db_xref="GOA:O31452" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="PDB:4CCY" /db_xref="SubtiList:BG12740" /db_xref="UniProtKB/Swiss-Prot:O31452" /translation="MIQDSMQFAAVESGLRFYQAYDQSLSLWPIESEAFYVSTRFGKT HIIASGPKDAPSLILLHGGLFSSAMWYPNIAAWSSQFRTYAVDIIGDKNKSIPSAAME TRADFAEWMKDVFDSLGLETAHLAGLSLGGSHIVNFLLRAPERVERAVVISPAEAFIS FHPDVYKYAAELTGARGAESYIKWITGDSYDLHPLLQRQIVAGVEWQDEQRSLKPTEN GFPYVFTDQELKSIQVPVLLMFGEHEAMYHQQMAFERASVLVPGIQAEIVKNAGHLLS LEQPEYVNQRVLSFLCGGIK*" /label="cesB CDS" gene 228225..229115 /gene="cesB" /locus_tag="BSU_02260" /old_locus_tag="BSU02260" /label="cesB gene" promotor_-35 228459..228466 /Source="Nicolas_upshift_promotors" /id="U160" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.867132867132867" /psig="0.867132867132867" /xcortree=2736 /SigmaFactorBS="ttttcagctctgcgatgtggtatccgaatatcgcagcgtgga gcAGTCAATTtcgtacatatgcgGTCGATATAATAGGAGACAaaaataaaagtatacc a" /listShort="S88, pssA, ybfM, psd" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 228475 /Source="Nicolas_upshifts" /id="U160" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.867132867132867" /psig="0.867132867132867" /xcortree=2736 /SigmaFactorBS="ttttcagctctgcgatgtggtatccgaatatcgcagcgtgga gcAGTCAATTtcgtacatatgcgGTCGATATAATAGGAGACAaaaataaaagtatacc a" /listShort="S88, pssA, ybfM, psd" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 228480..228498 /Source="Nicolas_upshift_promotors" /id="U160" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.867132867132867" /psig="0.867132867132867" /xcortree=2736 /SigmaFactorBS="ttttcagctctgcgatgtggtatccgaatatcgcagcgtgga gcAGTCAATTtcgtacatatgcgGTCGATATAATAGGAGACAaaaataaaagtatacc a" /listShort="S88, pssA, ybfM, psd" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 229116..229310 /Source="Nicolas_S_feature" /locus_tag="new_247549_247743" /HighExp="Cold, LBGstat, Paraq, Oxctl, H2O2, dia15, G135, Diami, Lbexp, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigA" /TUshortPSig="0.867, 1" /TUlongSig="SigEF" /TUlongPSig="0.973" /label="S88" CDS 229311..229844 /gene="pssA" /locus_tag="BSU_02270" /old_locus_tag="BSU02270" /EC_number="2.7.8.8" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14762009, 15743965, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14762009, 15743965, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphatidylserine synthase" /protein_id="NP_388109.1" /db_xref="EnsemblGenomes-Gn:BSU02270" /db_xref="EnsemblGenomes-Tr:CAB12021" /db_xref="GOA:P39823" /db_xref="InterPro:IPR000462" /db_xref="InterPro:IPR004533" /db_xref="SubtiList:BG11012" /db_xref="UniProtKB/Swiss-Prot:P39823" /translation="MNYIPCMITIGNFICGLLAIHSLLYHNIHSAVLFIFTGMFLDFF DGMAARKLNAVSDMGRELDSFADLVTFGVAPSMLAYSVALYTLPFIGILCALTYSICG MLRLSKFNIEQSKLPTFIGMPIPFAGMCLVILSFTYNPILLAIGTCGLSYLMVSKIKF PHFKKHAAENLESGRWN*" /label="pssA CDS" gene 229311..229844 /gene="pssA" /locus_tag="BSU_02270" /old_locus_tag="BSU02270" /label="pssA gene" CDS 229835..230323 /gene="ybfM" /locus_tag="BSU_02280" /old_locus_tag="BSU02280" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12682299, 14762009, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane phosphatase" /protein_id="NP_388110.1" /db_xref="EnsemblGenomes-Gn:BSU02280" /db_xref="EnsemblGenomes-Tr:CAB12022" /db_xref="GOA:O31453" /db_xref="InterPro:IPR032816" /db_xref="SubtiList:BG12741" /db_xref="UniProtKB/Swiss-Prot:O31453" /translation="MELVQQLIADYGYLAIFLMLVLGIVGLPIPDEVMMTVVGYFTHT DVLNYELSILISFVGALLGMLISYMIGRKAGRPFIDKYGKWVGLKEKRMMKVEKWMKK YGPYSLILGYFIPGVRHVTCYFSGIGKMDLKTYVAFAAIGAFLWCFVFITIGRVIGII HV*" /label="ybfM CDS" gene 229835..230323 /gene="ybfM" /locus_tag="BSU_02280" /old_locus_tag="BSU02280" /label="ybfM gene" CDS 230316..231107 /gene="psd" /locus_tag="BSU_02290" /old_locus_tag="BSU02290" /EC_number="4.1.1.65" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 14762009, 9422599" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14762009, 9422599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphatidylserine decarboxylase; 32 kDa precursor processed into a 29 kDa protein" /protein_id="NP_388111.1" /db_xref="EnsemblGenomes-Gn:BSU02290" /db_xref="EnsemblGenomes-Tr:CAB12023" /db_xref="GOA:P39822" /db_xref="InterPro:IPR003817" /db_xref="InterPro:IPR033177" /db_xref="InterPro:IPR033178" /db_xref="SubtiList:BG11013" /db_xref="UniProtKB/Swiss-Prot:P39822" /translation="MFNTAVKILYRSLIELTNHRLSSYLIKGFCESKISKPVIPLFSK HFRLNWDDVDGTAADYGSLSELFIRQINLERRPVSKEAHAVVSPVDGVVQTVGIINPN QTFTVKGKDYSFAELTGCKSADHQYNGGYFVVLYLSPRHYHRFHSPISCRYQKLAELG NRSYPVNQLGLKYGKDVLSKNYRFVYELNSGSRNVLMIPVGAMNINSIVQTNTRTELE IGEELGYFSFGSTVILVFEKDAFQPSAHLAEGQEVQVGELIGYEE*" /label="psd CDS" gene 230316..231107 /gene="psd" /locus_tag="BSU_02290" /old_locus_tag="BSU02290" /label="psd gene" downshifts 231082 /Source="Nicolas_upshifts" /id="D86" /incds=0 /nref=101 /ntot=236 /MaxReadThrough="3.18138" /MaxDrop="4.25536" /score="-2.98360164" /energy="-8" /TU="U159" /idTUdmin="U160" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 231162..231440 /gene="ybfN" /locus_tag="BSU_02300" /old_locus_tag="BSU02300" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388112.1" /db_xref="EnsemblGenomes-Gn:BSU02300" /db_xref="EnsemblGenomes-Tr:CAB12024" /db_xref="SubtiList:BG12742" /db_xref="UniProtKB/Swiss-Prot:O31454" /translation="MEKQIISWITDYQNTGDEAVLRQVREVCWPIVEAVLQEKVMDDE QANNLREKGIERFPFIISKYQADVQLPVETFLQNTYRFYFHQVMRESS*" /label="ybfN CDS" gene 231162..231440 /gene="ybfN" /locus_tag="BSU_02300" /old_locus_tag="BSU02300" /label="ybfN gene" promotor_-35 231483..231492 /Source="Nicolas_upshift_promotors" /id="U161" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1688 /SigmaFactorBS="agcttctttcaacagagaagcttttttttgttggcaggaaaa GGAAACTTTTtctatatctatcTCGTAATGACTAGAGAacctagcagaaaaggagaga t" /listShort="ybfO, ybfP, S89, ybfQ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 231501 /Source="Nicolas_upshifts" /id="U161" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1688 /SigmaFactorBS="agcttctttcaacagagaagcttttttttgttggcaggaaaa GGAAACTTTTtctatatctatcTCGTAATGACTAGAGAacctagcagaaaaggagaga t" /listShort="ybfO, ybfP, S89, ybfQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 231505..231520 /Source="Nicolas_upshift_promotors" /id="U161" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1688 /SigmaFactorBS="agcttctttcaacagagaagcttttttttgttggcaggaaaa GGAAACTTTTtctatatctatcTCGTAATGACTAGAGAacctagcagaaaaggagaga t" /listShort="ybfO, ybfP, S89, ybfQ" /GFF_Attribute="listLong" /label="promotor_-10" CDS 231546..232886 /gene="ybfO" /locus_tag="BSU_02310" /old_locus_tag="BSU02310" /EC_number="3.-.-.-" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative exported hydrolase" /protein_id="NP_388113.1" /db_xref="EnsemblGenomes-Gn:BSU02310" /db_xref="EnsemblGenomes-Tr:CAB12025" /db_xref="GOA:O31455" /db_xref="InterPro:IPR007815" /db_xref="SubtiList:BG12743" /db_xref="UniProtKB/Swiss-Prot:O31455" /translation="MKRMIVRMTLPLLIVCLAFSSFSASARAASEEKYWDHWIERHAQ PLDASNASNKDLRFLKKVLKGKRIVQLGETTHGAGEINATKVRMIKYLHEELGYDVLA FESGFPDTNASYLNMDQLTPKSTMKNSIYAVWHTEDVVELFDYMKEQKEKGDPLILTG FDIQSMKNSFNVAATQWVKAVDPEKAELLSQSENDFSTLVTDSNTFDEFSQKKEKLVK NYQKLIKFTKTHASELKENLPKEPKAYEMFMHSLQLRIDVMETYMLEEMKEKLEEYPE NIEDFSFFMRDRMMAEQFQWVADTLYPKKKIIVWGHNYHLRKQNTKMIKDWVQLNGPN MGDYLPERLKKQTYTIGIYAYSGASLDSSDNKTVKPVTSPPPSGSLEALLKAADRPAV FVDFLHTKNKKGTSWMYTPRTALYWGYMEEQMILKEQYDGVIWLEHITPSVIIK*" /label="ybfO CDS" gene 231546..232886 /gene="ybfO" /locus_tag="BSU_02310" /old_locus_tag="BSU02310" /label="ybfO gene" downshifts 232886 /Source="Nicolas_upshifts" /id="D87" /incds=0 /nref=12 /ntot=60 /MaxReadThrough="3.64301" /MaxDrop="6.34998" /score="14.4442651" /energy="-13.3" /TU="U161" /idTUdmin="U162" /TUdmin="-1122" /isTUend="FALSE" /label="downshifts" upshifts 232952 /Source="Nicolas_upshifts" /id="U162" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.582417582417582" /psig="0.838161838161838" /xcortree=1579 /SigmaFactorBS="gtcccctgtggtaaacaggggatttttacatatcgcaaaaat aatcaaaacatataatccgtgATCCATTATTCTAAAACAGAaaggagattggagcgtg c" /listShort="ybfP, S89" /listLong="ybfQ" /label="upshifts" misc_feature 232955..232974 /Source="Nicolas_upshift_promotors" /id="U162" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.582417582417582" /psig="0.838161838161838" /xcortree=1579 /SigmaFactorBS="gtcccctgtggtaaacaggggatttttacatatcgcaaaaat aatcaaaacatataatccgtgATCCATTATTCTAAAACAGAaaggagattggagcgtg c" /listShort="ybfP, S89" /listLong="ybfQ" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 232994..233881 /gene="ybfP" /locus_tag="BSU_02320" /old_locus_tag="BSU02320" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (AraC/XylS family)" /protein_id="NP_388114.1" /db_xref="EnsemblGenomes-Gn:BSU02320" /db_xref="EnsemblGenomes-Tr:CAB12026" /db_xref="GOA:O31456" /db_xref="InterPro:IPR008979" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR018060" /db_xref="SubtiList:BG12744" /db_xref="UniProtKB/Swiss-Prot:O31456" /translation="MYYEKAVQKTINWIESHLHEQISNEDIVNVSSFSKFHFHRIFQK EVGMSVASYIRLRRLANAAAALLYTDHRIIDIALYYQFESQEAFTRTFKKMYHMPPGA YRTFMKRFTSKKEESYMEKKMKGWVLSGSHPFQFEMGIDRENVHQGKASGYLKSTMVQ DIGEFATMMQQFKADRYLGKRLRLSSFIKTKGVQHFASLWMRVDSAADDVLQFDNMSN RPITGTTNWNHYAIVLDVPENSAVISFGVQLSGPGQVWMDHVVFEEVDESVPSTNLEM PGELLDEPVNLSFEEELQK*" /label="ybfP CDS" gene 232994..233881 /gene="ybfP" /locus_tag="BSU_02320" /old_locus_tag="BSU02320" /label="ybfP gene" S_feature 233882..234025 /Source="Nicolas_S_feature" /locus_tag="new_252315_252458" /HighExp="T0.30H, T-1.40H, T0.0H, T-1.10H, Salt, aero, ferm, T-0.40H, T-2.40H, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigWXY" /TUshortPSig="0.838, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S89" promotor_-35 233997..234004 /Source="Nicolas_upshift_promotors" /id="U163" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2069 /SigmaFactorBS="gcttggatatttttatcagtctgggcggatCTGTTCATcttt gcggcatttTCCTGTATGATATAGTAAGAgtgtgcatagcaactaactataattgaac a" /listShort="ybfQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 234018..234037 /Source="Nicolas_upshift_promotors" /id="U163" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2069 /SigmaFactorBS="gcttggatatttttatcagtctgggcggatCTGTTCATcttt gcggcatttTCCTGTATGATATAGTAAGAgtgtgcatagcaactaactataattgaac a" /listShort="ybfQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 234027 /Source="Nicolas_upshifts" /id="U163" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.754245754245754" /psig=1 /xcortree=2069 /SigmaFactorBS="gcttggatatttttatcagtctgggcggatCTGTTCATcttt gcggcatttTCCTGTATGATATAGTAAGAgtgtgcatagcaactaactataattgaac a" /listShort="ybfQ" /GFF_Attribute="listLong" /label="upshifts" CDS 234081..235049 /gene="ybfQ" /locus_tag="BSU_02330" /old_locus_tag="BSU02330" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10939241, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme with rhodanese domain" /protein_id="NP_388115.1" /db_xref="EnsemblGenomes-Gn:BSU02330" /db_xref="EnsemblGenomes-Tr:CAB12027" /db_xref="InterPro:IPR001763" /db_xref="InterPro:IPR020936" /db_xref="InterPro:IPR022111" /db_xref="InterPro:IPR036873" /db_xref="SubtiList:BG12745" /db_xref="UniProtKB/Swiss-Prot:O31457" /translation="MEKQYRVLLYYKYVPIEDPEAFREQHLAFCKELGLLGRILVSSE GINGTVSGTVEQTEKYMETMKADPRFADMVFKIDEAEGHAFKKIFVRHKKELVTLRLE DDVDPNETTGQHLKPAEFYEKMQDPNTIVIDARNDYEYDLGHFRGAVRPDIEAFRELP EWIEEHKDMLEGKKILTYCTGGVRCEKFSGWLVKQGFEDVAQLDGGIVTYGKDPEVQG KLWDGQCYVFDERISVPVNRVEHVIVGKDYFTGEPCERYVNCANPSCNKKMICTPENE YKYMRSCSHECRTNPRNLYVKEHNMTEEEVNARLAAIETEDHAAAE*" /label="ybfQ CDS" gene 234081..235049 /gene="ybfQ" /locus_tag="BSU_02330" /old_locus_tag="BSU02330" /label="ybfQ gene" promotor_-10 complement(234903..234921) /Source="Nicolas_upshift_promotors" /id="U164" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=798 /SigmaFactorBS="attatgctctttcacatacaggtttcttgggttcgtgcGGCA TTcgtggctgcagctgcGCATATATTTATACTCATTttccggtgtgcatatcattttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(234920) /Source="Nicolas_upshifts" /id="U164" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=798 /SigmaFactorBS="attatgctctttcacatacaggtttcttgggttcgtgcGGCA TTcgtggctgcagctgcGCATATATTTATACTCATTttccggtgtgcatatcattttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(234937..234942) /Source="Nicolas_upshift_promotors" /id="U164" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=798 /SigmaFactorBS="attatgctctttcacatacaggtttcttgggttcgtgcGGCA TTcgtggctgcagctgcGCATATATTTATACTCATTttccggtgtgcatatcattttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 235046 /Source="Nicolas_upshifts" /id="D88" /incds=0 /nref=238 /ntot=271 /MaxReadThrough="2.06825" /MaxDrop="7.49655" /score="4.11635522" /energy="-7.8" /TU="U163" /idTUdmin="U161" /TUdmin=4 /isTUend="TRUE" /label="downshifts" downshifts complement(235085) /Source="Nicolas_upshifts" /id="D89" /incds=0 /nref=59 /ntot=147 /MaxReadThrough="0.54212" /MaxDrop="6.33244" /score="2.56774646" /energy="-7.5" /TU="NA" /idTUdmin="U165" /TUdmin=11 /isTUend="TRUE" /label="downshifts" CDS complement(235085..236329) /gene="gltP" /locus_tag="BSU_02340" /old_locus_tag="BSU02340" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7751298, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7751298, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="proton/glutamate symport protein" /protein_id="NP_388116.1" /db_xref="EnsemblGenomes-Gn:BSU02340" /db_xref="EnsemblGenomes-Tr:CAB12028" /db_xref="GOA:P39817" /db_xref="InterPro:IPR001991" /db_xref="InterPro:IPR018107" /db_xref="InterPro:IPR033380" /db_xref="InterPro:IPR036458" /db_xref="SubtiList:BG11015" /db_xref="UniProtKB/Swiss-Prot:P39817" /translation="MKKLIAFQILIALAVGAVIGHFFPDFGMALRPVGDGFIRLIKMI VVPIVFSTIVIGAAGSGSMKKMGSLGIKTIIWFEVITTLVLGLGLLLANVLKPGVGLD LSHLAKKDIHELSGYTDKVVDFKQMILDIIPTNIIDVMARNDLLAVIFFAILFGVAAA GIGKASEPVMKFFESTAQIMFKLTQIVMVTAPIGVLALMAASVGQYGIELLLPMFKLV GTVFLGLFLILFVLFPLVGLIFQIKYFEVLKMIWDLFLIAFSTTSTETILPQLMDRME KYGCPKRVVSFVVPSGLSLNCDGSSLYLSVSCIFLAQAFQVDMTLSQQLLMMLVLVMT SKGIAAVPSGSLVVLLATANAVGLPAEGVAIIAGVDRVMDMARTGVNVPGHAIACIVV SKWEKAFRQKEWVSANSQTESI*" /label="gltP CDS" gene complement(235085..236329) /gene="gltP" /locus_tag="BSU_02340" /old_locus_tag="BSU02340" /label="gltP gene" promotor_-10 complement(236363..236381) /Source="Nicolas_upshift_promotors" /id="U165" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=525 /SigmaFactorBS="tgaaagcgctgtcaaaataaaataacttgaaaAAAGGTGTTt gcatttgaaTCACGAATGATATGAATATgcctacattctatcgttctaaagggggatt c" /listShort="gltP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(236372) /Source="Nicolas_upshifts" /id="U165" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=525 /SigmaFactorBS="tgaaagcgctgtcaaaataaaataacttgaaaAAAGGTGTTt gcatttgaaTCACGAATGATATGAATATgcctacattctatcgttctaaagggggatt c" /listShort="gltP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(236392..236400) /Source="Nicolas_upshift_promotors" /id="U165" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=525 /SigmaFactorBS="tgaaagcgctgtcaaaataaaataacttgaaaAAAGGTGTTt gcatttgaaTCACGAATGATATGAATATgcctacattctatcgttctaaagggggatt c" /listShort="gltP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(236400..236418) /Source="Nicolas_upshift_promotors" /id="U166" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.949050949050949" /psig="0.949050949050949" /xcortree=797 /SigmaFactorBS="taaaaaagtcccccctgctgcgggggactttttcgccAACAT AatgaaagcgctgtcaAAATAAAATAACTTGAAAAaaggtgtttgcatttgaatcacg a" /listShort="gltP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(236416) /Source="Nicolas_upshifts" /id="U166" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.949050949050949" /psig="0.949050949050949" /xcortree=797 /SigmaFactorBS="taaaaaagtcccccctgctgcgggggactttttcgccAACAT AatgaaagcgctgtcaAAATAAAATAACTTGAAAAaaggtgtttgcatttgaatcacg a" /listShort="gltP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(236434..236439) /Source="Nicolas_upshift_promotors" /id="U166" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.949050949050949" /psig="0.949050949050949" /xcortree=797 /SigmaFactorBS="taaaaaagtcccccctgctgcgggggactttttcgccAACAT AatgaaagcgctgtcaAAATAAAATAACTTGAAAAaaggtgtttgcatttgaatcacg a" /listShort="gltP" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(236474..238369) /gene="gamP" /locus_tag="BSU_02350" /old_locus_tag="BSU02350" /EC_number="2.7.1.193" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10627040, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) glucosamine-specific enzyme IICBA component" /protein_id="NP_388117.1" /db_xref="EnsemblGenomes-Gn:BSU02350" /db_xref="EnsemblGenomes-Tr:CAB12029" /db_xref="GOA:P39816" /db_xref="InterPro:IPR001127" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR011055" /db_xref="InterPro:IPR011299" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="SubtiList:BG11014" /db_xref="UniProtKB/Swiss-Prot:P39816" /translation="MFKKAFQILQQLGRALMTPVAVLPAAGLLLRFGDKDLLNIPIIK DAGGVVFDNLPLIFAVGVAIGLAGGEGVAGLAAVIGYLILTVTLDNMGKLLGLQPPYE GAEHLIDMGVFGGIIIGLLAAYLYKRFSSIELHPVLGFFSGKRFVPIITSVSSLVIGV IFSFVWPLIQNGINAASSLIADSTVGLFFYATIYRLLIPFGLHHIFYTPFYFMMGEYT DPSTGNTVTGDLTRFFAGDPTAGRFMMGDFPYMIFCLPAVALAIIHTARPEKKKMISG VMISAALTSMLTGITEPVEFSFLFVAPVLYLINSILAGVIFVVCDLFHVRHGYTFSGG GIDYVLNYGLSTNGWVVIPVGIVFAFIYYYLFRFAILKWNLKTPGRETDEDGQNEEKA PVAKDQLAFHVLQALGGQQNIANLDACITRLRVTVHQPSQVCKDELKRLGAVGVLEVN NNFQAIFGTKSDALKDDIKTIMAGGVPATAAALDTVTDKPLKPDSDETFIYPIKGETV SLGDVPDQVFSEKMMGEGFAIIPSEGKVVAPADGEIVSIFPTKHAIGFMSAGGTEILI HVGIDTVKLNGEGFEAHVTSGQAVKQGELLLTFDLNYIKQHAASAITPVIFTNTSEED LKHIQMK*" /label="gamP CDS" gene complement(236474..238369) /gene="gamP" /locus_tag="BSU_02350" /old_locus_tag="BSU02350" /label="gamP gene" downshifts complement(236490) /Source="Nicolas_upshifts" /id="D90" /incds=0 /nref=56 /ntot=192 /MaxReadThrough="1.9947" /MaxDrop="6.51864" /score="5.87664177" /energy="-12.1" /TU="NA" /idTUdmin="U168" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" misc_feature 238235..238254 /Source="Nicolas_upshift_promotors" /id="U167" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.701298701298701" /psig="0.975024975024975" /xcortree=2747 /SigmaFactorBS="cggcgaaaatcagcggaaggttatcgaatacaacgccgcccg cATCCTTTATAATAGGGATGTtcagtaaatccttgtctccgaaacggagcaaaagacc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 238252 /Source="Nicolas_upshifts" /id="U167" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.701298701298701" /psig="0.975024975024975" /xcortree=2747 /SigmaFactorBS="cggcgaaaatcagcggaaggttatcgaatacaacgccgcccg cATCCTTTATAATAGGGATGTtcagtaaatccttgtctccgaaacggagcaaaagacc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(238390..239139) /gene="gamA" /locus_tag="BSU_02360" /old_locus_tag="BSU02360" /EC_number="3.5.99.6" /function="16.11: Scavenge (Catabolism)" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:23667565, 27002132" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23667565, 27002132; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucosamine-6-phosphate deaminase" /protein_id="NP_388118.1" /db_xref="EnsemblGenomes-Gn:BSU02360" /db_xref="EnsemblGenomes-Tr:CAB12030" /db_xref="GOA:O31458" /db_xref="InterPro:IPR004547" /db_xref="InterPro:IPR006148" /db_xref="InterPro:IPR018321" /db_xref="SubtiList:BG12746" /db_xref="UniProtKB/Swiss-Prot:O31458" /translation="MKILIAEHYEELCKLSAAIIKEQIQAKKDAVLGLATGSTPVGLY KQLISDYQAGEIDFSKVTTFNLDEYAGLSPSHPQSYNHFMHEHLFQHINMQPDHIHIP QGDNPQLEAACKVYEDLIRQAGGIDVQILGIGANGHIGFNEPGSDFEDRTRVVKLSES TIQANARFFGGDPVLVPRLAISMGIKTIMEFSKHIVLLASGEEKADAIQKMAEGPVTT DVPASILQKHNHVTVIADYKAAQKLKSASFS*" /label="gamA CDS" gene complement(238390..239139) /gene="gamA" /locus_tag="BSU_02360" /old_locus_tag="BSU02360" /label="gamA gene" S_feature 239112..239293 /Source="Nicolas_S_feature" /locus_tag="new_257545_257726" /HighExp="H2O2, T1.30H, G135, dia15, G150, G180, LBGstat, T2.0H, T0.30H, M9-stat" /AntisenseName="nagBB" /AntisenseCor="0.458837556034909" /AntisenseRegPval="-14.7" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S90" S_feature complement(239140..239210) /Source="Nicolas_S_feature" /locus_tag="new_257573_257643_c" /HighExp="S1, Diami, MG 5, MG t5, dia5, MG 15, MG 10, LPhT, Paraq, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S91" promotor_-10 complement(239199..239218) /Source="Nicolas_upshift_promotors" /id="U168" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2202 /SigmaFactorBS="atccttcttttataacaaattttcagaaattaaTATTGACAg tttgataagggcggTGCTAAATTCGTAATGACAAgtatcataaattggtcataacaaa t" /listShort="S91, nagBB, nagP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(239214) /Source="Nicolas_upshifts" /id="U168" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2202 /SigmaFactorBS="atccttcttttataacaaattttcagaaattaaTATTGACAg tttgataagggcggTGCTAAATTCGTAATGACAAgtatcataaattggtcataacaaa t" /listShort="S91, nagBB, nagP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(239234..239241) /Source="Nicolas_upshift_promotors" /id="U168" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2202 /SigmaFactorBS="atccttcttttataacaaattttcagaaattaaTATTGACAg tttgataagggcggTGCTAAATTCGTAATGACAAgtatcataaattggtcataacaaa t" /listShort="S91, nagBB, nagP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 239280..239287 /Source="Nicolas_upshift_promotors" /id="U169" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.662337662337662" /psig=1 /xcortree=1865 /SigmaFactorBS="gtcaatattaatttctgaaaatttgttataaaagaaggatac aaaTCTTTCATattgggagggcaAATGGTATTATGGTCTCAATgaaaaagaacggatt g" /listShort="ybgA, ybgB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 239295 /Source="Nicolas_upshifts" /id="U169" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.662337662337662" /psig=1 /xcortree=1865 /SigmaFactorBS="gtcaatattaatttctgaaaatttgttataaaagaaggatac aaaTCTTTCATattgggagggcaAATGGTATTATGGTCTCAATgaaaaagaacggatt g" /listShort="ybgA, ybgB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 239300..239319 /Source="Nicolas_upshift_promotors" /id="U169" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.662337662337662" /psig=1 /xcortree=1865 /SigmaFactorBS="gtcaatattaatttctgaaaatttgttataaaagaaggatac aaaTCTTTCATattgggagggcaAATGGTATTATGGTCTCAATgaaaaagaacggatt g" /listShort="ybgA, ybgB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 239358..240065 /gene="gamR" /locus_tag="BSU_02370" /old_locus_tag="BSU02370" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:23667565, 24673833" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23667565, 24673833; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator-GlcN6P (GntR family)" /protein_id="NP_388119.1" /db_xref="EnsemblGenomes-Gn:BSU02370" /db_xref="EnsemblGenomes-Tr:CAB12031" /db_xref="GOA:O31459" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR011663" /db_xref="InterPro:IPR028978" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12747" /db_xref="UniProtKB/Swiss-Prot:O31459" /translation="MTALYSVIKFKIIELIKSGKYQANDQLPTESEFCEQYDVSRTTV RLALQQLELEGYIKRIQGKGTFVSAAKIQTPIPHKITSFAEQMRGLRSESKVLELVVI PADHSIAELLKMKENEPVNKLVRVRYAEGEPLQYHTSYIPWKAAPGLAQEECTGSLFE LLRTKYNIEISRGTESIEPILTDETISGHLLTNVGAPAFLSESLTYDKNEEVVEYAQI ITRGDRTKFTVEQSYHS*" /label="gamR CDS" gene 239358..240065 /gene="gamR" /locus_tag="BSU_02370" /old_locus_tag="BSU02370" /label="gamR gene" promotor_-35 240031..240032 /Source="Nicolas_upshift_promotors" /id="U170" /multdbtbs="SigY" /comp="M9" /sig="Sig-" /pcomp="0.41958041958042" /psig="0.41958041958042" /xcortree=1684 /SigmaFactorBS="aatatgcgcaaattattacacggggagaccgaaCGaaattca ccgtagaaCAGTCATATCATTCAtaaagcaatgtgttttaagaagggaatggtggttc t" /listShort="ybgB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 240048..240062 /Source="Nicolas_upshift_promotors" /id="U170" /multdbtbs="SigY" /comp="M9" /sig="Sig-" /pcomp="0.41958041958042" /psig="0.41958041958042" /xcortree=1684 /SigmaFactorBS="aatatgcgcaaattattacacggggagaccgaaCGaaattca ccgtagaaCAGTCATATCATTCAtaaagcaatgtgttttaagaagggaatggtggttc t" /listShort="ybgB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 240058 /Source="Nicolas_upshifts" /id="U170" /multdbtbs="SigY" /comp="M9" /sig="Sig-" /pcomp="0.41958041958042" /psig="0.41958041958042" /xcortree=1684 /SigmaFactorBS="aatatgcgcaaattattacacggggagaccgaaCGaaattca ccgtagaaCAGTCATATCATTCAtaaagcaatgtgttttaagaagggaatggtggttc t" /listShort="ybgB" /GFF_Attribute="listLong" /label="upshifts" CDS 240099..240374 /gene="ybgB" /locus_tag="BSU_02380" /old_locus_tag="BSU02380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12897008, 23667565" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (B. subtilis-specific)" /protein_id="NP_388120.1" /db_xref="EnsemblGenomes-Gn:BSU02380" /db_xref="EnsemblGenomes-Tr:CAB12032" /db_xref="GOA:O31460" /db_xref="InterPro:IPR012867" /db_xref="SubtiList:BG12748" /db_xref="UniProtKB/Swiss-Prot:O31460" /translation="MFLFTNGKVLWGAVIAAFILSIVFYPFLPTQMPIHYDVANSPDL TVNKLAGTVMLPVLMVVFAWARKINWQFVFAVYILLICHIVVLCLAL*" /label="ybgB CDS" gene 240099..240374 /gene="ybgB" /locus_tag="BSU_02380" /old_locus_tag="BSU02380" /label="ybgB gene" promotor_-10 complement(240157..240175) /Source="Nicolas_upshift_promotors" /id="U171" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=112 /SigmaFactorBS="ggactgttcgcaacatcataatgaatcGGCATCTgcgtcggc agaaaaGGGTAAAATACAATTGAAAggatgaatgcagcaatcactgctccccacagca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(240163) /Source="Nicolas_upshifts" /id="U171" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=112 /SigmaFactorBS="ggactgttcgcaacatcataatgaatcGGCATCTgcgtcggc agaaaaGGGTAAAATACAATTGAAAggatgaatgcagcaatcactgctccccacagca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(240190..240196) /Source="Nicolas_upshift_promotors" /id="U171" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=112 /SigmaFactorBS="ggactgttcgcaacatcataatgaatcGGCATCTgcgtcggc agaaaaGGGTAAAATACAATTGAAAggatgaatgcagcaatcactgctccccacagca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 240366 /Source="Nicolas_upshifts" /id="D91" /incds=0 /nref=20 /ntot=130 /MaxReadThrough="2.42422" /MaxDrop="3.75723" /score="4.58454735" /energy="-9.4" /TU="NA" /idTUdmin="U169" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 240417..240421 /Source="Nicolas_upshift_promotors" /id="U172" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.641358641358641" /psig="0.998001998001998" /xcortree=2879 /SigmaFactorBS="gccagaataaaactggctgttttctttaatttcaGCTTCatc tgacaatgaatgTGGTGTATAATAGCTGATGAtcctaaagaatattctgaaatttata g" /listShort="S92, ilvE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 240437..240456 /Source="Nicolas_upshift_promotors" /id="U172" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.641358641358641" /psig="0.998001998001998" /xcortree=2879 /SigmaFactorBS="gccagaataaaactggctgttttctttaatttcaGCTTCatc tgacaatgaatgTGGTGTATAATAGCTGATGAtcctaaagaatattctgaaatttata g" /listShort="S92, ilvE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 240443 /Source="Nicolas_upshifts" /id="U172" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.641358641358641" /psig="0.998001998001998" /xcortree=2879 /SigmaFactorBS="gccagaataaaactggctgttttctttaatttcaGCTTCatc tgacaatgaatgTGGTGTATAATAGCTGATGAtcctaaagaatattctgaaatttata g" /listShort="S92, ilvE" /GFF_Attribute="listLong" /label="upshifts" S_feature 240454..240582 /Source="Nicolas_S_feature" /locus_tag="new_258887_259015" /HighExp="T2.30H, S5, T2.0H, T1.30H, M9-stat, T3.0H, T3.30H, S4, T1.0H, T-0.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S92" CDS 240583..241653 /gene="ilvE" /locus_tag="BSU_02390" /old_locus_tag="BSU02390" /EC_number="2.6.1.42" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12670965, 15060025, 15102328, 20332210, 23429746" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12670965, 15060025, 15102328, 20332210, 23429746; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isoleucine-valine aminotransferase / aromatic amino acid aminotransferase" /protein_id="NP_388121.1" /db_xref="EnsemblGenomes-Gn:BSU02390" /db_xref="EnsemblGenomes-Tr:CAB12033" /db_xref="GOA:O31461" /db_xref="InterPro:IPR001544" /db_xref="InterPro:IPR005786" /db_xref="InterPro:IPR018300" /db_xref="InterPro:IPR033939" /db_xref="InterPro:IPR036038" /db_xref="SubtiList:BG12749" /db_xref="UniProtKB/Swiss-Prot:O31461" /translation="MNKLIEREKTVYYKEKPDPSSLGFGQYFTDYMFVMDYEEGIGWH HPRIAPYAPLTLDPSSSVFHYGQAVFEGLKAYRTDDGRVLLFRPDQNIKRLNRSCERM SMPPLDEELVLEALTQLVELEKDWVPKEKGTSLYIRPFVIATEPSLGVKASRSYTFMI VLSPVGSYYGDDQLKPVRIYVEDEYVRAVNGGVGFAKTAGNYAASLQAQRKANELGYD QVLWLDAIEKKYVEEVGSMNIFFVINGEAVTPALSGSILSGVTRASAIELIRSWGIPV REERISIDEVYAASARGELTEVFGTGTAAVVTPVGELNIHGKTVIVGDGQIGDLSKKL YETITDIQLGKVKGPFNWTVEV*" /label="ilvE CDS" gene 240583..241653 /gene="ilvE" /locus_tag="BSU_02390" /old_locus_tag="BSU02390" /label="ilvE gene" downshifts 241642 /Source="Nicolas_upshifts" /id="D92" /incds=0 /nref=124 /ntot=245 /MaxReadThrough="1.34575" /MaxDrop="6.88046" /score="13.1364544" /energy="-9.4" /TU="NA" /idTUdmin="U172" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(241690..243102) /gene="ybgF" /locus_tag="BSU_02400" /old_locus_tag="BSU02400" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7704263, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative aminoacid permease" /protein_id="NP_388122.1" /db_xref="EnsemblGenomes-Gn:BSU02400" /db_xref="EnsemblGenomes-Tr:CAB12034" /db_xref="GOA:O31462" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG12750" /db_xref="UniProtKB/Swiss-Prot:O31462" /translation="MNSAHNKNETTFQRSMKSRHLFMLSLGGVIGTGLFLSSGYTIQQ AGPAGTILAYLVGAGIVYLVMLCLGELSVAMPVTGAFHTYAAKYIGPGTGFTVAWLYW LTWTVALGSEFTAAGLLMQRWFPHTSVWMWSAVFALFIFLLNAFSVKFFAESEFWFSS IKVLAIVLFILLGGSAMFGIIPIKGGEAAPMLSNFTAEGGLFPNGFVPILMTMLSVNF AFSGTELIGIAAGESVDPDKTIPKAIKTTVWRLSLFFVGTIFVLSGLIPIQDAGVIKS PFVAVFDRVGVPYAADIMNFVILTAILSAANSGLYASSRMLWSLSKEKTLHPTFAKLT SKGTPFNALVFSMIGGILSLLSSVFAPDTVYVVLVSISGFAVVVVWMGIAASQFMFRK RYIEAGNKVTDLKYRTPLYPFVPIAAFLLCLASVVGIAFDPNQRIALYCGVPFMAICY AIYYVKNRKSQPAADMTHSK*" /label="ybgF CDS" gene complement(241690..243102) /gene="ybgF" /locus_tag="BSU_02400" /old_locus_tag="BSU02400" /label="ybgF gene" downshifts complement(241707) /Source="Nicolas_upshifts" /id="D93" /incds=0 /nref=43 /ntot=166 /MaxReadThrough="0.37503" /MaxDrop="5.92001" /score="6.94246417" /energy="-9.4" /TU="NA" /idTUdmin="U173" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" S_feature complement(243103..243214) /Source="Nicolas_S_feature" /locus_tag="new_261536_261647_c" /HighExp="BMM, S1, MG 45, MG 60, UNK1, MG t5, MG 10, MG 90, MG-0.2, M9-exp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.999" /label="S93" promotor_-10 complement(243187..243206) /Source="Nicolas_upshift_promotors" /id="U173" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=3071 /SigmaFactorBS="cgaaaatattcaagaaattgcggcttgggcccgctctttaaa aacaACTTGACTtatcggaatagtttGTATATTCTAACTTAAAGCCggttcgccggag t" /listShort="S93, ybgF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(243214) /Source="Nicolas_upshifts" /id="U173" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=3071 /SigmaFactorBS="cgaaaatattcaagaaattgcggcttgggcccgctctttaaa aacaACTTGACTtatcggaatagtttGTATATTCTAACTTAAAGCCggttcgccggag t" /listShort="S93, ybgF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(243221..243228) /Source="Nicolas_upshift_promotors" /id="U173" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=3071 /SigmaFactorBS="cgaaaatattcaagaaattgcggcttgggcccgctctttaaa aacaACTTGACTtatcggaatagtttGTATATTCTAACTTAAAGCCggttcgccggag t" /listShort="S93, ybgF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(243223..244170) /gene="ybgG" /locus_tag="BSU_02410" /old_locus_tag="BSU02410" /EC_number="2.1.1.10" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11267663, 15995196, 17264075; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="homocysteine methylase using (R,S)AdoMet" /protein_id="NP_388123.1" /db_xref="EnsemblGenomes-Gn:BSU02410" /db_xref="EnsemblGenomes-Tr:CAB12035" /db_xref="GOA:O31463" /db_xref="InterPro:IPR003726" /db_xref="InterPro:IPR017226" /db_xref="InterPro:IPR036589" /db_xref="SubtiList:BG12751" /db_xref="UniProtKB/Swiss-Prot:O31463" /translation="MNPIQHILDTYPLIVLDGAMATELERKGCNLNDSLWSAKILMEE PELIKQVHTDYFAAGADCAITASYQSTFEGFAARGLSEAEARRLIELSVSIAAEARDE FWSLEENRLNRPKPIIAASIGPYGAYLADGSEYRGNYAISEDELIEFHRPRMKALIEA GADVLACETIPCLTEAKAIVRLLKEFPETYAWISFSAKDGLHISDGTPAADCASWLDE HRQIAALGINCTPLQHIPSLIEELKKNTSKPIIVYPNSGEQYDPETKTWNGAACAESY GASARTWHEKGARLIGGCCRTKPENIQEIAAWARSLKTT*" /label="ybgG CDS" gene complement(243223..244170) /gene="ybgG" /locus_tag="BSU_02410" /old_locus_tag="BSU02410" /label="ybgG gene" promotor_-10 complement(244208..244227) /Source="Nicolas_upshift_promotors" /id="U174" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig="0.999000999001" /xcortree=3068 /SigmaFactorBS="agacatatgggctgaacacctttctctttttgcgttTATTGA CAaacacgtaagcctcCATTACGATTTTCATATCTTtttcaaaaaaatctgaaagaag g" /listShort="ybgG" /listLong="S93, ybgF" /label="promotor_-10" upshifts complement(244225) /Source="Nicolas_upshifts" /id="U174" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig="0.999000999001" /xcortree=3068 /SigmaFactorBS="agacatatgggctgaacacctttctctttttgcgttTATTGA CAaacacgtaagcctcCATTACGATTTTCATATCTTtttcaaaaaaatctgaaagaag g" /listShort="ybgG" /listLong="S93, ybgF" /label="upshifts" promotor_-35 complement(244242..244249) /Source="Nicolas_upshift_promotors" /id="U174" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig="0.999000999001" /xcortree=3068 /SigmaFactorBS="agacatatgggctgaacacctttctctttttgcgttTATTGA CAaacacgtaagcctcCATTACGATTTTCATATCTTtttcaaaaaaatctgaaagaag g" /listShort="ybgG" /listLong="S93, ybgF" /label="promotor_-35" CDS complement(244299..245735) /gene="glnT" /locus_tag="BSU_02420" /old_locus_tag="BSU02420" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15849754, 15995196, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="glutamine transporter" /protein_id="NP_388124.2" /db_xref="EnsemblGenomes-Gn:BSU02420" /db_xref="EnsemblGenomes-Tr:CAB12036" /db_xref="GOA:O31464" /db_xref="InterPro:IPR001463" /db_xref="SubtiList:BG12752" /db_xref="UniProtKB/Swiss-Prot:O31464" /translation="MQQILEHIVGIANDLLWSKLLIVLLLSFGIYFTFRLKFLQVRML KEMVRVLREGAASRSKNSISPFQAFCISMAARVGTGNITGIAIAIALGGPGAIFWMWI IAIIGSASSFVESTLAQIYKVKDVNGFRGGPAYYMEKGLNKRWMGALFAVLITLSFGI VFNSVQSNTVSLAFENAFGTNRLTLGLILIAVFGTIIFGGVKRIAKLAESIVVVLAVL YIGVAFFVIFSNITQLPGVLALIVKNAFGFDQAAGGALGAALMQGVRRGIFSNEAGMG SAPNAAATATTSHPVKQGLIQAFGVLTDTLVICTSTAFIILFSDAYHTPGLSGIALTQ ASLSSHVGSWASGFLAILILLFGFCALIGNYYYGETNIGFLNKSKKLIFVYRIGVLAM IVFGCVAKVQLVWDLADLFMGLMVIVNLIAIFLLSKVVFTALKDYTRQKKAGKDPVFY KDVLKNHNGIECWPVSDTKTDTHNKQIS*" /label="glnT CDS" gene complement(244299..245735) /gene="glnT" /locus_tag="BSU_02420" /old_locus_tag="BSU02420" /label="glnT gene" downshifts complement(244314) /Source="Nicolas_upshifts" /id="D94" /incds=0 /nref=3 /ntot=3 /MaxReadThrough="0.598370000000001" /MaxDrop="4.3935" /score="-7.90227391" /energy="-11.4" /TU="NA" /idTUdmin="U174" /TUdmin="-1078" /isTUend="FALSE" /label="downshifts" CDS complement(245758..246741) /gene="glsA" /locus_tag="BSU_02430" /old_locus_tag="BSU02430" /EC_number="3.5.1.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15995196, 18459799, 20050917" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15995196, 18459799, 20050917; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutaminase" /protein_id="NP_388125.1" /db_xref="EnsemblGenomes-Gn:BSU02430" /db_xref="EnsemblGenomes-Tr:CAB12037" /db_xref="GOA:O31465" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR015868" /db_xref="PDB:1MKI" /db_xref="PDB:2OSU" /db_xref="PDB:3AGF" /db_xref="PDB:3BRM" /db_xref="SubtiList:BG12753" /db_xref="UniProtKB/Swiss-Prot:O31465" /translation="MKELIKEHQKDINPALQLHDWVEYYRPFAANGQSANYIPALGKV NDSQLGICVLEPDGTMIHAGDWNVSFTMQSISKVISFIAACMSRGIPYVLDRVDVEPT GDAFNSIIRLEINKPGKPFNPMINAGALTIASILPGESAYEKLEFLYSVMETLIGKRP RIHEEVFRSEWETAHRNRALAYYLKETNFLEAEVEETLEVYLKQCAMESTTEDIALIG LILAHDGYHPIRHEQVIPKDVAKLAKALMLTCGMYNASGKYAAFVGVPAKSGVSGGIM ALVPPSARREQPFQSGCGIGIYGPAIDEYGNSLTGGMLLKHMAQEWELSIF*" /label="glsA CDS" gene complement(245758..246741) /gene="glsA" /locus_tag="BSU_02430" /old_locus_tag="BSU02430" /label="glsA gene" promotor_-10 complement(246835..246852) /Source="Nicolas_upshift_promotors" /id="U175" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.71028971028971" /psig="0.97002997002997" /xcortree=1548 /SigmaFactorBS="tgcttattttcaaaatgtttttgtcgtATTTTGTAtgattct gtagtctcCATTATACAGTAATTATAccttccgctattatgaaagcgtttaacgcccc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature 246840..246859 /Source="Nicolas_upshift_promotors" /id="U176" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.908091908091908" /psig=1 /xcortree=1812 /SigmaFactorBS="tcaaaacgaaggctaagggggcgttaaacgctttcataatag cggaaggtataaTTACTGTATAATGGAGACTAcagaatcatacaaaatacgacaaaaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(246842) /Source="Nicolas_upshifts" /id="U175" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.71028971028971" /psig="0.97002997002997" /xcortree=1548 /SigmaFactorBS="tgcttattttcaaaatgtttttgtcgtATTTTGTAtgattct gtagtctcCATTATACAGTAATTATAccttccgctattatgaaagcgtttaacgcccc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts 246846 /Source="Nicolas_upshifts" /id="U176" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.908091908091908" /psig=1 /xcortree=1812 /SigmaFactorBS="tcaaaacgaaggctaagggggcgttaaacgctttcataatag cggaaggtataaTTACTGTATAATGGAGACTAcagaatcatacaaaatacgacaaaaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(246868..246875) /Source="Nicolas_upshift_promotors" /id="U175" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.71028971028971" /psig="0.97002997002997" /xcortree=1548 /SigmaFactorBS="tgcttattttcaaaatgtttttgtcgtATTTTGTAtgattct gtagtctcCATTATACAGTAATTATAccttccgctattatgaaagcgtttaacgcccc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 247043..248275 /gene="glnJ" /locus_tag="BSU_02440" /old_locus_tag="BSU02440" /EC_number="2.7.13.3" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295, 15995196, 17001076, 21435182, 23461034, 25691471" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15995196, 17001076, 21435182, 23461034, 25691471; Product type rc : receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [GlnL] forglutamine degradation" /protein_id="NP_388126.2" /db_xref="EnsemblGenomes-Gn:BSU02440" /db_xref="EnsemblGenomes-Tr:CAB12038" /db_xref="GOA:P40758" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG10871" /db_xref="UniProtKB/Swiss-Prot:P40758" /translation="MLITVPLAGELKFYPLNEEFRVSFGAPVFFFFLSLLRHVPAVLP GFLTGAAVFIFRVFLELWGGGHNGLTPILYDQASGFFFYMTYACLFSILKANRFRERP IMLGFIGFMIEVVSDCVELTVQFLIFHTVVTPEKITDIAVIAISHTFIVMSFYSVLKL YETQSREKQTRQQHEHMLMIVSNLYEETVHLKKTLKTTEKVTNDSYQLYREMKGKDVQ LSGRILRLAGEIHEVKKDNQRIFAGLSKLISNESLRDYMRASDLLQLVIRMNEKYAEA LGKQIDFYCSIEGEHDEYHVFIVLSIINNLTANAVEAMDEEGMVSLRLRKPNESMVEF QVEDNGPGISEKIGDIVFDPGFTSKYDEFGTPSTGIGLSYVKEIVTELEGDITFDNQQ RGVVFAIRLPVRHLIQKG*" /label="glnJ CDS" gene 247043..248275 /gene="glnJ" /locus_tag="BSU_02440" /old_locus_tag="BSU02440" /label="glnJ gene" CDS 248286..249230 /gene="glnL" /locus_tag="BSU_02450" /old_locus_tag="BSU02450" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 15995196" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15995196; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [GlnJ] for glutamine utilisation" /protein_id="NP_388127.1" /db_xref="EnsemblGenomes-Gn:BSU02450" /db_xref="EnsemblGenomes-Tr:CAB12039" /db_xref="GOA:P40759" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR013972" /db_xref="SubtiList:BG10872" /db_xref="UniProtKB/Swiss-Prot:P40759" /translation="MRFFIADDDRAVRSILRQIIEDEDLGEAAGEADDGSQVEGHMLQ FKQIDILLIDLLMPGRDGIETIRQIQNTYSGKIVMISQVEAKEMVGEAYSLGIEYFIH KPINRIEIVTVLQKVKERIELEHSIGAIQHSLSRLVNRTERKARPQQKSDSGLKEAGT FLLSELGMMGEGGAHDLMAVLQYLAEHEQSEPHEKQSPSLKQIFTQVAVRKLGTGASQ TEVNREMKASEQRIRRAIIHSLHHFASLGTTDFSNPKFETYASKFFDFPVVSQKMKEL QSKDAKPLAPARINMKKFIHVFFLEAKLLHETMKQRRI*" /label="glnL CDS" gene 248286..249230 /gene="glnL" /locus_tag="BSU_02450" /old_locus_tag="BSU02450" /label="glnL gene" downshifts 249207 /Source="Nicolas_upshifts" /id="D95" /incds=0 /nref=45 /ntot=191 /MaxReadThrough="1.43757" /MaxDrop="3.64091" /score="2.73020459" /energy="-6.2" /TU="NA" /idTUdmin="U177" /TUdmin="-484" /isTUend="FALSE" /label="downshifts" promotor_-35 249327..249334 /Source="Nicolas_upshift_promotors" /id="U177" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.982017982017982" /psig="0.999000999001" /xcortree=370 /SigmaFactorBS="gccggacagtgatttaccgcttttttataaaatatcagaaaa taaagaTATTGACTtattgtttatttgTCTTACAATTAAACAAAAGGatatatgggaa g" /listShort="S94, ycbC" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 249339..249456 /Source="Nicolas_S_feature" /locus_tag="new_267772_267889" /HighExp="Sw, BC, M40t90, Etha, MG-0.2, HiTm, HiOs, G135, UNK1, MG-0.1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S94" upshifts 249339 /Source="Nicolas_upshifts" /id="U177" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.982017982017982" /psig="0.999000999001" /xcortree=370 /SigmaFactorBS="gccggacagtgatttaccgcttttttataaaatatcagaaaa taaagaTATTGACTtattgtttatttgTCTTACAATTAAACAAAAGGatatatgggaa g" /listShort="S94, ycbC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 249348..249367 /Source="Nicolas_upshift_promotors" /id="U177" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.982017982017982" /psig="0.999000999001" /xcortree=370 /SigmaFactorBS="gccggacagtgatttaccgcttttttataaaatatcagaaaa taaagaTATTGACTtattgtttatttgTCTTACAATTAAACAAAAGGatatatgggaa g" /listShort="S94, ycbC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 249457..250383 /gene="kdgD" /locus_tag="BSU_02460" /old_locus_tag="BSU02460" /EC_number="4.2.1.41" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12044674; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="5-dehydro-4-deoxyglucarate dehydratase" /protein_id="NP_388128.2" /db_xref="EnsemblGenomes-Gn:BSU02460" /db_xref="EnsemblGenomes-Tr:CAB12040" /db_xref="GOA:P42235" /db_xref="InterPro:IPR002220" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR017655" /db_xref="SubtiList:BG11158" /db_xref="UniProtKB/Swiss-Prot:P42235" /translation="MSRIRKAPAGILGFPVAPFNTQGKLEEEALFQNIEFLLNEGLEA IFIACGSGEFQSLSQKEYEQMVEVAVSAAGGKVPVYTGVGGNLSTALDWAQLSEKKGA DGYLILPPYLVHGEQEGLYQYAKTIIESTDLNAILYQRDNAVLSVEQIKRLTECEQLV GVKDGVGNMDLNINLVYTIGDRLGWLNGMPMAEVTMPAYLPIGFHSYSSAISNYIPHI SRMFYDALKNGNDELVKELYRHVILPINDIRKQRKGYAVSLIKAGMEIMGLNVRNTAR PPVGPVEKDHYQQLEAILKQAADRFPKKAATV*" /label="kdgD CDS" gene 249457..250383 /gene="kdgD" /locus_tag="BSU_02460" /old_locus_tag="BSU02460" /label="kdgD gene" CDS 250413..251879 /gene="gucD" /locus_tag="BSU_02470" /old_locus_tag="BSU02470" /EC_number="1.2.1.26" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12044674, 17202142; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2,5-dioxovalerate dehydrogenase (alpha-ketoglutaric semialdehyde dehydrogenase)" /protein_id="NP_388129.1" /db_xref="EnsemblGenomes-Gn:BSU02470" /db_xref="EnsemblGenomes-Tr:CAB12041" /db_xref="GOA:P42236" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016160" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="SubtiList:BG11159" /db_xref="UniProtKB/Swiss-Prot:P42236" /translation="MSVITEQNTYLNFINGEWVKSQSGDMVKVENPADVNDIVGYVQN STAEDVERAVTAANEAKTAWRKLTGAERGQYLYKTADIMEQRLEEIAACATREMGKTL PEAKGETARGIAILRYYAGEGMRKTGDVIPSTDKDALMFTTRVPLGVVGVISPWNFPV AIPIWKMAPALVYGNTVVIKPATETAVTCAKIIACFEEAGLPAGVINLVTGPGSVVGQ GLAEHDGVNAVTFTGSNQVGKIIGQAALARGAKYQLEMGGKNPVIVADDADLEAAAEA VITGAFRSTGQKCTATSRVIVQSGIYERFKEKLLQRTKDITIGDSLKEDVWMGPIASK NQLDNCLSYIEKGKQEGASLLIGGEKLENGKYQNGYYVQPAIFDNVTSEMTIAQEEIF GPVIALIKVDSIEEALNIANDVKFGLSASIFTENIGRMLSFIDEIDAGLVRINAESAG VELQAPFGGMKQSSSHSREQGEAAKDFFTAIKTVFVKP*" /label="gucD CDS" gene 250413..251879 /gene="gucD" /locus_tag="BSU_02470" /old_locus_tag="BSU02470" /label="gucD gene" CDS 251963..253330 /gene="gudP" /locus_tag="BSU_02480" /old_locus_tag="BSU02480" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12044674, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12044674, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="glucarate transporter" /protein_id="NP_388130.2" /db_xref="EnsemblGenomes-Gn:BSU02480" /db_xref="EnsemblGenomes-Tr:CAB12042" /db_xref="GOA:P42237" /db_xref="InterPro:IPR000849" /db_xref="InterPro:IPR004744" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11160" /db_xref="UniProtKB/Swiss-Prot:P42237" /translation="MKKDFASVTPAGKKTSVRWFIVFMLFLVTSINYADRATLSITGD SVQHDLGLDSVAMGYVFSAFGWAYVIGQLPGGWLLDRFGSKTIIALSIFFWSFFTLLQ GAIGFFSAGTAIILLFALRFLVGLSEAPSFPGNGRVVASWFPSSERGTASAFFNSAQY FAIVIFSPLMGWLTHSFGWHSVFVVMGIAGILLAVIWLKTVYEPKKHPKVNEAELAYI EQGGGLISMDDSKSKQETESKWPYIKQLLTNRMLIGVYIAQYCITTLTYFFLTWFPVY LVQARGMSILEAGFVASLPALCGFAGGVLGGIVSDILLKKGRSLTFARKVPIIAGMLL SCSMIVCNYTDSAWLVVVIMSLAFFGKGFGALGWAVVSDTSPKECAGLSGGLFNTFGN IASITTPIIIGYIVNATGSFNGALVFVGANAIAAILSYLLLVGPIKRVVLKKQEQDPD QSLPV*" /label="gudP CDS" gene 251963..253330 /gene="gudP" /locus_tag="BSU_02480" /old_locus_tag="BSU02480" /label="gudP gene" CDS 253367..254734 /gene="gudD" /locus_tag="BSU_02490" /old_locus_tag="BSU02490" /EC_number="4.2.1.40" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9772161, 12044674; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucarate dehydratase" /protein_id="NP_388131.2" /db_xref="EnsemblGenomes-Gn:BSU02490" /db_xref="EnsemblGenomes-Tr:CAB12043" /db_xref="GOA:P42238" /db_xref="InterPro:IPR013342" /db_xref="InterPro:IPR017653" /db_xref="InterPro:IPR029017" /db_xref="InterPro:IPR029065" /db_xref="InterPro:IPR034390" /db_xref="InterPro:IPR034598" /db_xref="InterPro:IPR036849" /db_xref="SubtiList:BG11161" /db_xref="UniProtKB/Swiss-Prot:P42238" /translation="MSSPIQEQVQKEKRSNIPSISEMKVIPVAGHDSMLLNLSGAHSP FFTRNIVILTDSSGNQGVGEVPGGEHIRRTLELSEPLVVGKSIGAYQAILQTVRKQFG DQDRGGRGNQTFDLRTTVHAVTALEAALLDLLGKFLQEPVAALLGEGKQRDEVKMLGY LFYIGDRNRTTLPYQSDEQSDCAWFRLRHEEALTPEAIVRLAESAQERYGFQDFKLKG GVLRGEEEIEAVTALSKRFPEARITLDPNGAWSLEEAIALCKGKQDVLAYAEDPCGDE NGYSAREVMAEFRRATGLPTATNMIATDWREMGHAIQLHAVDIPLADPHFWTMQGSVR VAQMCHDWGLTWGSHSNNHFDISLAMFTHVAAAAPGRITAIDTHWIWQDGQRLTKQPF EISSGCVKVPDKPGLGVDIDMEQVEKAHEIYRKMNLGARNDAIPMQFLISNWEFDRKR PCLVR*" /label="gudD CDS" gene 253367..254734 /gene="gudD" /locus_tag="BSU_02490" /old_locus_tag="BSU02490" /label="gudD gene" promotor_-35 254748..254755 /Source="Nicolas_upshift_promotors" /id="U178" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig="0.999000999001" /xcortree=2135 /SigmaFactorBS="gcgcccgtgtcttgtgcgataagtttgattgtaaaTATTGTC AtatccgctattttgTCTTACAATTGAACAACTgaagggagagttgttcgtgtacgaa g" /listShort="ycbG, garD" /listLong="S95, ycbJ, NA" /label="promotor_-35" promotor_-10 254770..254787 /Source="Nicolas_upshift_promotors" /id="U178" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig="0.999000999001" /xcortree=2135 /SigmaFactorBS="gcgcccgtgtcttgtgcgataagtttgattgtaaaTATTGTC AtatccgctattttgTCTTACAATTGAACAACTgaagggagagttgttcgtgtacgaa g" /listShort="ycbG, garD" /listLong="S95, ycbJ, NA" /label="promotor_-10" upshifts 254773 /Source="Nicolas_upshifts" /id="U178" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig="0.999000999001" /xcortree=2135 /SigmaFactorBS="gcgcccgtgtcttgtgcgataagtttgattgtaaaTATTGTC AtatccgctattttgTCTTACAATTGAACAACTgaagggagagttgttcgtgtacgaa g" /listShort="ycbG, garD" /listLong="S95, ycbJ, NA" /label="upshifts" CDS 254804..255505 /gene="garR" /locus_tag="BSU_02500" /old_locus_tag="BSU02500" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12044674" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12044674; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (GntR family)" /protein_id="NP_388132.2" /db_xref="EnsemblGenomes-Gn:BSU02500" /db_xref="EnsemblGenomes-Tr:CAB12044" /db_xref="GOA:P42239" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR008920" /db_xref="InterPro:IPR011711" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11162" /db_xref="UniProtKB/Swiss-Prot:P42239" /translation="MYEGLEDLKVDTVNRKTLAKQVIERIVHLLSSGQLRAGDKLPTE MELMDILHVSRPVLREALSSLETLGVITRKTRGGTYFNDKIGMQPFSVMLALATDNLP AIIEARMALELGLVTIAAEKINEEELQRLQKTIDDIANSTDNHYGEADKEFHRIIALS ANNPVVEGMIQSLLITHAKIDSQIPYRERDVTVEYHKKIYDALAKRDPYKAHYHMYEH LKFVRDKILKGMDEK*" /label="garR CDS" gene 254804..255505 /gene="garR" /locus_tag="BSU_02500" /old_locus_tag="BSU02500" /label="garR gene" downshifts 255455 /Source="Nicolas_upshifts" /id="D96" /incds=0 /nref=1 /ntot=35 /MaxReadThrough="3.59234" /MaxDrop="2.3923" /score="4.10541728" /energy="-9.5" /TU="U178" /idTUdmin="U178" /TUdmin="-1694" /isTUend="FALSE" /label="downshifts" downshifts 255499 /Source="Nicolas_upshifts" /id="D97" /incds=0 /nref=1 /ntot=82 /MaxReadThrough="3.21794" /MaxDrop="2.49226" /score="4.10541728" /energy="-9.5" /TU="U178" /idTUdmin="U178" /TUdmin="-1650" /isTUend="FALSE" /label="downshifts" CDS 255596..257128 /gene="garD" /locus_tag="BSU_02510" /old_locus_tag="BSU02510" /EC_number="4.2.1.42" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9772162; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="D-galactarate dehydratase" /protein_id="NP_388133.2" /db_xref="EnsemblGenomes-Gn:BSU02510" /db_xref="EnsemblGenomes-Tr:CAB12045" /db_xref="GOA:P42240" /db_xref="InterPro:IPR007392" /db_xref="InterPro:IPR013974" /db_xref="InterPro:IPR017654" /db_xref="SubtiList:BG11163" /db_xref="UniProtKB/Swiss-Prot:P42240" /translation="MAMNLRKNQAPLYIKVHEIDNTAIIVNDGGLPKGTVFSCGLVLE EDVPQGHKVALTDLNQGDEIVRYGEVIGFADETIKRGSWIREALVRMPAPPALDDLPL ANRVPQPRPPLEGYTFEGYRNADGSAGTKNILGITTSVQCVVGVLDYAVKRIKEELLP KYPNVDDVVPLHHQYGCGVAINAPDAVIPIRTIQNLAKHPNFGGEVMVIGLGCEKLLP ERIASENDDDILSLQDHRGFAAMIQSILEMAEERLIRLNSRTRVSCPVSDLVIGLQCG GSDAFSGVTANPAVGYAADLLVRAGATVLFSEVTEVRDAIHLLTPRAVSEEVGQSLIK EMKWYDSYLRRGDADRSANPSPGNKKGGLSNVVEKALGSVAKSGTSPISGVLGPGERA KQKGLLFAATPASDFVCGTLQLAAGMNLQVFTTGRGTPYGLAAAPVLKVSTRHSLSEH WADLIDINAGRIATGEASIEDVGWEIFRTILDVASGRKQTWADRWGLHNDLCLFNPAP VT*" /label="garD CDS" gene 255596..257128 /gene="garD" /locus_tag="BSU_02510" /old_locus_tag="BSU02510" /label="garD gene" promotor_-35 257140..257143 /Source="Nicolas_upshift_promotors" /id="U179" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=422 /SigmaFactorBS="tcctgctccagtgacttgattcatgtttttATAGcggaaaga tggaatATGCTGTAAAATGAAAATCAgcgtataggaaacggaggggttacagcatggc a" /listShort="S95, ycbJ, NA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 257158..257177 /Source="Nicolas_upshift_promotors" /id="U179" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=422 /SigmaFactorBS="tcctgctccagtgacttgattcatgtttttATAGcggaaaga tggaatATGCTGTAAAATGAAAATCAgcgtataggaaacggaggggttacagcatggc a" /listShort="S95, ycbJ, NA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 257170..257404 /Source="Nicolas_S_feature" /locus_tag="new_275603_275837" /HighExp="LoTm, Sw, BC, BI, B60, B36, T3.30H, T5.0H, T4.0H, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.50265400000000005" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.999" /label="S95" upshifts 257170 /Source="Nicolas_upshifts" /id="U179" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=422 /SigmaFactorBS="tcctgctccagtgacttgattcatgtttttATAGcggaaaga tggaatATGCTGTAAAATGAAAATCAgcgtataggaaacggaggggttacagcatggc a" /listShort="S95, ycbJ, NA" /GFF_Attribute="listLong" /label="upshifts" CDS 257405..258325 /gene="ycbJ" /locus_tag="BSU_02520" /old_locus_tag="BSU02520" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12044674; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphotransferase" /protein_id="NP_388134.1" /db_xref="EnsemblGenomes-Gn:BSU02520" /db_xref="EnsemblGenomes-Tr:CAB12046" /db_xref="GOA:P42242" /db_xref="InterPro:IPR002575" /db_xref="InterPro:IPR011009" /db_xref="SubtiList:BG11165" /db_xref="UniProtKB/Swiss-Prot:P42242" /translation="MTNLNEKQLITEIVGLARSQGLTVHSENAQLNETGMDFQVVFAK DDTGMPWVLRKPRRSDVVERASAEGITLAFLRANLTADVPDWRIHTPELIAYPMLKGT PAAGIDLEQKQYVWNMDHQPPSDDFVRTLADILAELHGTDQISAGQSGIEVIRPEDFR QMTADSMVDVKNKLGVSTTLWERWQKWVDDDAYWPGFSSLIHGDLHPPHILIDQNGRV TGLLDWTEAKVADPAKDFVLYQTIFGEKETARLLEYYDQAGGRIWAKMQEHISEMQAA YPVEIAKLALQTQQEEHINMALEALGVTSD*" /label="ycbJ CDS" gene 257405..258325 /gene="ycbJ" /locus_tag="BSU_02520" /old_locus_tag="BSU02520" /label="ycbJ gene" promotor_-35 258327..258334 /Source="Nicolas_upshift_promotors" /id="U180" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.869130869130869" /psig=1 /xcortree=572 /SigmaFactorBS="gaagcacttggtgtaacatcggattaagAATTGACTtcgttt catgaaccGAGTATTATAAACTCTACAAataatagaacggattaacaatcgtgaggaa g" /listShort="NA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 258349..258368 /Source="Nicolas_upshift_promotors" /id="U180" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.869130869130869" /psig=1 /xcortree=572 /SigmaFactorBS="gaagcacttggtgtaacatcggattaagAATTGACTtcgttt catgaaccGAGTATTATAAACTCTACAAataatagaacggattaacaatcgtgaggaa g" /listShort="NA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 258359 /Source="Nicolas_upshifts" /id="U180" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.869130869130869" /psig=1 /xcortree=572 /SigmaFactorBS="gaagcacttggtgtaacatcggattaagAATTGACTtcgttt catgaaccGAGTATTATAAACTCTACAAataatagaacggattaacaatcgtgaggaa g" /listShort="NA" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 258382..258629 /gene="tboW" /locus_tag="BSU_misc_RNA_6" /product="T-box riboswitch specific of tryptophan tRNA ligase" /experiment="publication(s) with functional evidences, PMID:1317842, 9098041, 10706627, 12165569, 12547201" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1317842, 9098041, 10706627, 12165569, 12547201; Product type n: RNA" /label="tboW RNA" gene 258382..258629 /gene="tboW" /locus_tag="BSU_misc_RNA_6" /label="tboW gene" downshifts 258598 /Source="Nicolas_upshifts" /id="D98" /incds=0 /nref=225 /ntot=264 /MaxReadThrough="2.36361" /MaxDrop="6.52913" /score="36.5571172" /energy="-16.6" /TU="NA" /idTUdmin="U179" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" CDS 258727..258888 /gene="rtpA" /locus_tag="BSU_02530" /old_locus_tag="BSU02530" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10706627, 11557884, 12855807, 15099736, 15213402, 15743934, 16306262" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10706627, 11557884, 12855807, 15099736, 15213402, 15743934, 16306262; Product type r: regulator" /codon_start=1 /transl_table=11 /product="anti-TRAP regulator" /protein_id="NP_388135.1" /db_xref="EnsemblGenomes-Gn:BSU02530" /db_xref="EnsemblGenomes-Tr:CAB12047" /db_xref="GOA:O31466" /db_xref="InterPro:IPR031538" /db_xref="InterPro:IPR036410" /db_xref="PDB:2BX9" /db_xref="PDB:2KO8" /db_xref="PDB:2ZP8" /db_xref="PDB:2ZP9" /db_xref="SubtiList:BG12776" /db_xref="UniProtKB/Swiss-Prot:O31466" /translation="MVIATDDLEVACPKCERAGEIEGTPCPACSGKGVILTAQGYTLL DFIQKHLNK*" /label="rtpA CDS" gene 258727..258888 /gene="rtpA" /locus_tag="BSU_02530" /old_locus_tag="BSU02530" /label="rtpA gene" promotor_no_box 258805..258905 /Source="Nicolas_upshift_promotors" /id="U181" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.544455544455544" /psig="0.010989010989011" /xcortree=1479 /SigmaFactorBS="ccggcctgcagcggaaaaggtgttattctgactgctcaagga tatacgcttctcgattttatccaaaagcatttgaataagtaaaggagaaaagctgagc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 258865 /Source="Nicolas_upshifts" /id="U181" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.544455544455544" /psig="0.010989010989011" /xcortree=1479 /SigmaFactorBS="ccggcctgcagcggaaaaggtgttattctgactgctcaagga tatacgcttctcgattttatccaaaagcatttgaataagtaaaggagaaaagctgagc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 258909..259847 /gene="ycbK" /locus_tag="BSU_02540" /old_locus_tag="BSU02540" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10706627, 15063849, 15849754, 16850406, 16879415, 17114263; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative tryptophan or indole exporter" /protein_id="NP_388136.1" /db_xref="EnsemblGenomes-Gn:BSU02540" /db_xref="EnsemblGenomes-Tr:CAB12048" /db_xref="GOA:P42243" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG11166" /db_xref="UniProtKB/Swiss-Prot:P42243" /translation="MRAEEQSKIREAAAGTIFLLIGTVCFASKSIWIKWAYQMGAEPD AVLLYRQLLAVPLFWLIFLIYRPPMPDGKKKGDLWKACGAGVFCFFLSPLLDFIGLNH VSAMVERILLMSYPLFVFGFTACRDRKMSSIQDLFAVLAVMFGLFLALGGWNAELFQA NMIGAVFILLSSAVYAGYLVLSGHLVHQIGGIRLNAYGMTAAGAAMMLYTGIKSAAGM NTPMAAYPLSMYGLFAVIAVVTTVIPFVLMLEGIKRIGAQRAAAISMAGPILTIFYGA LFLGERLGLIQVIGCGGVFFVITGMEYRKLKTGKKE*" /label="ycbK CDS" gene 258909..259847 /gene="ycbK" /locus_tag="BSU_02540" /old_locus_tag="BSU02540" /label="ycbK gene" downshifts 258953 /Source="Nicolas_upshifts" /id="D99" /incds=0 /nref=1 /ntot=7 /MaxReadThrough="3.05417" /MaxDrop="3.72787" /score="0.773303272" /energy="-9" /TU="NA" /idTUdmin="U181" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature 259870..259889 /Source="Nicolas_upshift_promotors" /id="U182" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.699300699300699" /psig="0.998001998001998" /xcortree=2265 /SigmaFactorBS="tacaggaagctgaaaacaggaaaaaaagaataatttttataa aacacacacgtttTTCAATTACAATAAGTGTAAttacgtgtgtgttttttgattttgt a" /listShort="S96, ycbL, ycbM" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 259875..259943 /Source="Nicolas_S_feature" /locus_tag="new_278308_278376" /HighExp="C90, dia5, Lbtran, Lbexp, LBGexp, SMM, dia0, dia15, BMM, T-3.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S96" upshifts 259875 /Source="Nicolas_upshifts" /id="U182" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.699300699300699" /psig="0.998001998001998" /xcortree=2265 /SigmaFactorBS="tacaggaagctgaaaacaggaaaaaaagaataatttttataa aacacacacgtttTTCAATTACAATAAGTGTAAttacgtgtgtgttttttgattttgt a" /listShort="S96, ycbL, ycbM" /GFF_Attribute="listLong" /label="upshifts" CDS 259944..260624 /gene="ycbL" /locus_tag="BSU_02550" /old_locus_tag="BSU02550" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YcbM]" /protein_id="NP_388137.2" /db_xref="EnsemblGenomes-Gn:BSU02550" /db_xref="EnsemblGenomes-Tr:CAB12049" /db_xref="GOA:P42244" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11167" /db_xref="UniProtKB/Swiss-Prot:P42244" /translation="MLVEDDHSISEMVDHYLTKEGFGIVHAFDGEEGIRLFQQGSYDL VLLDIMLPKLNGMDFLKIIREKSNIPVLMISAKDGDVDKALGLGFGADDYIAKPFSMI ELTARVKAAIRRATQYSAEEPAVNKVIRIHQLAIDIDNVSVLKNGEPLQLTSTEWQLL CLFASNPKKVFTKEQIYRSVWNEEYFDDQNIINVHMRRLREKIEDDPSSPQYIKTLWG IGYKLGEF*" /label="ycbL CDS" gene 259944..260624 /gene="ycbL" /locus_tag="BSU_02550" /old_locus_tag="BSU02550" /label="ycbL gene" CDS 260626..261561 /gene="ycbM" /locus_tag="BSU_02560" /old_locus_tag="BSU02560" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YcbL]" /protein_id="NP_388138.2" /db_xref="EnsemblGenomes-Gn:BSU02560" /db_xref="EnsemblGenomes-Tr:CAB12050" /db_xref="GOA:P42245" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG11168" /db_xref="UniProtKB/Swiss-Prot:P42245" /translation="MTVLWVAAVIALACLNVIQFIMKKKRDGNLAYTADQLSYMLSRD SAGQILLPTDDHALKDLLVNINLIVENRQQISAQFAKTEQSMKRMLTNMSHDLKTPLT VILGYIEAIQSDPNMPDEERERLLGKLRQKTNELIQMINSFFDLAKLESEDKEIPITK VHMNDICKRNILHYYDAVQSKGFQAAIDIPDTPVYAQANEEALDRILQNLLSNAIQYG AAGKLIGLTLSYDERNIAITVWDRGKGISETDQQRVFERLYTLEESRNKAFQGSGLGL TITKRLTEKMGGIISVQSKPYERTAFTITLKRMTY*" /label="ycbM CDS" gene 260626..261561 /gene="ycbM" /locus_tag="BSU_02560" /old_locus_tag="BSU02560" /label="ycbM gene" CDS 261653..262576 /gene="ycbN" /locus_tag="BSU_02570" /old_locus_tag="BSU02570" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12486040; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC efflux transporter (ATP-binding protein)" /protein_id="NP_388139.2" /db_xref="EnsemblGenomes-Gn:BSU02570" /db_xref="EnsemblGenomes-Tr:CAB12051" /db_xref="GOA:P42246" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11169" /db_xref="UniProtKB/Swiss-Prot:P42246" /translation="MTYIVQTNGLTKTYQGKEVVSNVSMHIKKGEIYGFLGPNGAGKT TIMKMLTSLVKPTSGEIIILGNKFTHTSYEVLGNIGSMIEYPIFYENLTAEENLDLHC EYMGYHNKKAIQEVLDMVNLKQIDKKPVKTFSLGMKQRLGIARAILTKPDLLILDEPV NGLDPLGIKKIRQLFQVLSKEYGMTLLISSHLLGEIEQIADTIGVIRDGRLLEEVSME DVRGQNTEYIELVTPNQTRACFVLEKELQLTNFKILNEKTIRIYEAEASQAAISKALI LNDVDIESMNKKYTSLEDYFIKLINGNSISA*" /label="ycbN CDS" gene 261653..262576 /gene="ycbN" /locus_tag="BSU_02570" /old_locus_tag="BSU02570" /label="ycbN gene" S_feature complement(262123..263307) /Source="Nicolas_S_feature" /locus_tag="new_280556_281740_c" /HighExp="Etha, Sw, Gly, B36, LoTm, B60, GM 150, Salt, C30, ferm" /AntisenseName="ycbO" /AntisenseCor="-0.38911425676406203" /AntisenseRegPval="-10.4" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S97" CDS 262595..263281 /gene="ycbO" /locus_tag="BSU_02580" /old_locus_tag="BSU02580" /function="16.1: Circulate" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative Na+-driven exporter" /protein_id="NP_388140.3" /db_xref="EnsemblGenomes-Gn:BSU02580" /db_xref="EnsemblGenomes-Tr:CAB12052" /db_xref="GOA:P42247" /db_xref="InterPro:IPR032688" /db_xref="SubtiList:BG11170" /db_xref="UniProtKB/Swiss-Prot:P42247" /translation="MNLIRIELRKMKMGWYIRGALIANVIIMGFMWLISYSEKADGGV SFQSTDEAFLIIGTFVRAVFIVFGAVLIVKLVISEYKNKTILVMFTYPISRKKLLTAK LMIAGGLTFITILLSNILIAAGFFWLNSICHFIPGELTSEIISQQAVKMAVFAFGAAG TSLVPIFFGMRRHSVPATIISSVVIVMLISSTSPGFSISSVVYIPLSLAAFGLFFSYM AIRNADKQDA*" /label="ycbO CDS" gene 262595..263281 /gene="ycbO" /locus_tag="BSU_02580" /old_locus_tag="BSU02580" /label="ycbO gene" CDS complement(263242..263376) /locus_tag="BSU_02585" /old_locus_tag="BSU02585" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513940.1" /translation="MARSIILKQEQTHNGKAGADSIGLLYILGAFVYASCLSAFLIAM *" /label="hypothetical protein CDS" gene complement(263242..263376) /locus_tag="BSU_02585" /old_locus_tag="BSU02585" /label="gene" downshifts 263276 /Source="Nicolas_upshifts" /id="D100" /incds=0 /nref=8 /ntot=120 /MaxReadThrough="1.13131" /MaxDrop="3.44039" /score="18.1873505" /energy="-11.4" /TU="NA" /idTUdmin="U184" /TUdmin="-1166" /isTUend="FALSE" /label="downshifts" CDS complement(263336..263722) /gene="ycbP" /locus_tag="BSU_02590" /old_locus_tag="BSU02590" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22582280; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative inner integral membrane protein" /protein_id="NP_388141.1" /db_xref="EnsemblGenomes-Gn:BSU02590" /db_xref="EnsemblGenomes-Tr:CAB12053" /db_xref="GOA:P42248" /db_xref="InterPro:IPR019649" /db_xref="SubtiList:BG11171" /db_xref="UniProtKB/Swiss-Prot:P42248" /translation="MTHVKALAIKGIMTIIVLYLVLGLGFGFTFGDTLLMTIVLGVIS YLLGDLYVLPKWNNMIATLADFGLAFLVIWLMGMPLSMGMTGGEVALAALFGAIVMAI GEYCFHFYMMSKEIGKKHYLETRTDS*" /label="ycbP CDS" gene complement(263336..263722) /gene="ycbP" /locus_tag="BSU_02590" /old_locus_tag="BSU02590" /label="ycbP gene" downshifts complement(263352) /Source="Nicolas_upshifts" /id="D101" /incds=0 /nref=148 /ntot=217 /MaxReadThrough="6.64196" /MaxDrop="7.40353" /score="13.8182557" /energy="-15.6" /TU="U183" /idTUdmin="U185" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(263748..263766) /Source="Nicolas_upshift_promotors" /id="U183" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=164 /SigmaFactorBS="ctctccccagcagatttgcacccgcctccgaaaagaaataaG GTTTAActttttacatttgAGGAATTATACATAACAAAtcaaatgacaaaaggaggaa t" /listShort="ycbP, S97" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(263767) /Source="Nicolas_upshifts" /id="U183" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=164 /SigmaFactorBS="ctctccccagcagatttgcacccgcctccgaaaagaaataaG GTTTAActttttacatttgAGGAATTATACATAACAAAtcaaatgacaaaaggaggaa t" /listShort="ycbP, S97" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(263780..263786) /Source="Nicolas_upshift_promotors" /id="U183" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=164 /SigmaFactorBS="ctctccccagcagatttgcacccgcctccgaaaagaaataaG GTTTAActttttacatttgAGGAATTATACATAACAAAtcaaatgacaaaaggaggaa t" /listShort="ycbP, S97" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(263800..264798) /Source="Nicolas_S_feature" /locus_tag="new_282233_283231_c" /HighExp="GM 150, T0.30H, C30, T1.30H, T1.0H, T-0.40H, T-3.40H, T2.0H, T2.30H, T-4.40H" /AntisenseName="cwlJ" /AntisenseCor="0.11463160303596701" /AntisenseRegPval="-1.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.975" /TUlongSig="NA" /TUlongPSig="NA" /label="S98" downshifts complement(263843) /Source="Nicolas_upshifts" /id="D102" /incds=0 /nref=3 /ntot=10 /MaxReadThrough="5.23914" /MaxDrop="3.14515" /score="13.8182557" /energy="-15.6" /TU="U185,U187" /idTUdmin="U185" /TUdmin="-491" /isTUend="FALSE" /label="downshifts" promotor_-35 263979..263984 /Source="Nicolas_upshift_promotors" /id="U184" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1108 /SigmaFactorBS="gtttttagatgaataaatttaaaaacttctcctgtccctccG TCATCacttctgaagtaatgAAATATGATGAAAAGAGATcaaggggaggtgacgtgat g" /listShort="cwlJ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 263998 /Source="Nicolas_upshifts" /id="U184" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1108 /SigmaFactorBS="gtttttagatgaataaatttaaaaacttctcctgtccctccG TCATCacttctgaagtaatgAAATATGATGAAAAGAGATcaaggggaggtgacgtgat g" /listShort="cwlJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 264000..264018 /Source="Nicolas_upshift_promotors" /id="U184" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1108 /SigmaFactorBS="gtttttagatgaataaatttaaaaacttctcctgtccctccG TCATCacttctgaagtaatgAAATATGATGAAAAGAGATcaaggggaggtgacgtgat g" /listShort="cwlJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(264012) /Source="Nicolas_upshifts" /id="U185" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=680 /SigmaFactorBS="aatcgacatccgcactcgttgctctcacgaccGCCATcacgt caCCTCCCCTTGATCTCttttcatcatatttcattacttcagaagtgatgacggaggg a" /listShort="ycbP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(264014..264028) /Source="Nicolas_upshift_promotors" /id="U185" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=680 /SigmaFactorBS="aatcgacatccgcactcgttgctctcacgaccGCCATcacgt caCCTCCCCTTGATCTCttttcatcatatttcattacttcagaagtgatgacggaggg a" /listShort="ycbP" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(264034) /Source="Nicolas_upshifts" /id="D103" /incds=0 /nref=2 /ntot=5 /MaxReadThrough="5.64474" /MaxDrop="3.76775" /score="13.8182557" /energy="-15.6" /TU="U187" /idTUdmin="U185" /TUdmin="-682" /isTUend="FALSE" /label="downshifts" promotor_-35 complement(264036..264040) /Source="Nicolas_upshift_promotors" /id="U185" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=680 /SigmaFactorBS="aatcgacatccgcactcgttgctctcacgaccGCCATcacgt caCCTCCCCTTGATCTCttttcatcatatttcattacttcagaagtgatgacggaggg a" /listShort="ycbP" /GFF_Attribute="listLong" /label="promotor_-35" CDS 264036..264464 /gene="cwlJ" /locus_tag="BSU_02600" /old_locus_tag="BSU02600" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9515903, 11466292, 11807087, 12177332, 16936016, 26190134, 28333204" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9515903, 11466292, 11807087, 12177332, 16936016, 26190134, 28333204; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore cortex cell wall hydrolase" /protein_id="NP_388142.2" /db_xref="EnsemblGenomes-Gn:BSU02600" /db_xref="EnsemblGenomes-Tr:CAB12054" /db_xref="GOA:P42249" /db_xref="InterPro:IPR011105" /db_xref="SubtiList:BG11172" /db_xref="UniProtKB/Swiss-Prot:P42249" /translation="MAVVRATSADVDLMARLLRAEAEGEGKQGMLLVGNVGINRLRAN CSDFKGLRTIRQMIYQPHAFEAVTHGYFYQRARDSERALARRSINGERRWPAKFSLWY FRPQGDCPAQWYNQPFVARFKSHCFYQPTAETCENVYNTF*" /label="cwlJ CDS" gene 264036..264464 /gene="cwlJ" /locus_tag="BSU_02600" /old_locus_tag="BSU02600" /label="cwlJ gene" downshifts 264443 /Source="Nicolas_upshifts" /id="D104" /incds=0 /nref=44 /ntot=63 /MaxReadThrough="2.30044" /MaxDrop="5.89045" /score="18.1873505" /energy="-11.4" /TU="NA" /idTUdmin="U184" /TUdmin=1 /isTUend="TRUE" /label="downshifts" promotor_-35 264509..264515 /Source="Nicolas_upshift_promotors" /id="U186" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.535464535464535" /psig="0.973026973026973" /xcortree=1784 /SigmaFactorBS="ggacaccgttcaaattgaacggtgtttttctttgaaaagATG CAATgcaaaatattccTGTGAGATAATCAAAGAAAAaagagctgacggagatgacaga a" /listShort="ycbR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 264528..264547 /Source="Nicolas_upshift_promotors" /id="U186" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.535464535464535" /psig="0.973026973026973" /xcortree=1784 /SigmaFactorBS="ggacaccgttcaaattgaacggtgtttttctttgaaaagATG CAATgcaaaatattccTGTGAGATAATCAAAGAAAAaagagctgacggagatgacaga a" /listShort="ycbR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 264530 /Source="Nicolas_upshifts" /id="U186" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.535464535464535" /psig="0.973026973026973" /xcortree=1784 /SigmaFactorBS="ggacaccgttcaaattgaacggtgtttttctttgaaaagATG CAATgcaaaatattccTGTGAGATAATCAAAGAAAAaagagctgacggagatgacaga a" /listShort="ycbR" /GFF_Attribute="listLong" /label="upshifts" CDS 264570..265301 /gene="ycbR" /locus_tag="BSU_02610" /old_locus_tag="BSU02610" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388143.2" /db_xref="EnsemblGenomes-Gn:BSU02610" /db_xref="EnsemblGenomes-Tr:CAB12055" /db_xref="InterPro:IPR002035" /db_xref="InterPro:IPR019303" /db_xref="InterPro:IPR036465" /db_xref="SubtiList:BG11173" /db_xref="UniProtKB/Swiss-Prot:P42250" /translation="MATIDLQKKSVKIVLEKKQLTKVTARVGLVLDITGSMRPLYKNG TVQNVVERILAVADQFDDNGLLDVWVYDNEFSRLKPVSEKDFSGYVDREILNNDRLHK FGRNDEPPVMKDVLRKYVTEEPSSYPAFIVFINDGGCKKSIKPIIEASSDKPVFWQFV GIGNGNFDFLNKLDTLEGRVIDNTNFLHIEEIDRISDDELYDALLAEFPFWLKEAKEK GIVREQEPPAEKPKKKGFFSRLFSK*" /label="ycbR CDS" gene 264570..265301 /gene="ycbR" /locus_tag="BSU_02610" /old_locus_tag="BSU02610" /label="ycbR gene" promotor_-10 complement(264772..264791) /Source="Nicolas_upshift_promotors" /id="U187" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.932067932067932" /psig="0.975024975024975" /xcortree=2967 /SigmaFactorBS="tatttaaaatttcacgatcgacatagcccgaaaaatcctttt ctgaAACTGGCTttaatcgggaaaaTTCATTATCATACACCCATAcatccagcaaacc g" /listShort="S98, ycbP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(264798) /Source="Nicolas_upshifts" /id="U187" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.932067932067932" /psig="0.975024975024975" /xcortree=2967 /SigmaFactorBS="tatttaaaatttcacgatcgacatagcccgaaaaatcctttt ctgaAACTGGCTttaatcgggaaaaTTCATTATCATACACCCATAcatccagcaaacc g" /listShort="S98, ycbP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(264805..264812) /Source="Nicolas_upshift_promotors" /id="U187" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.932067932067932" /psig="0.975024975024975" /xcortree=2967 /SigmaFactorBS="tatttaaaatttcacgatcgacatagcccgaaaaatcctttt ctgaAACTGGCTttaatcgggaaaaTTCATTATCATACACCCATAcatccagcaaacc g" /listShort="S98, ycbP" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 265219 /Source="Nicolas_upshifts" /id="D105" /incds=1 /nref=9 /ntot=148 /MaxReadThrough="1.70712" /MaxDrop="3.61288" /score="25.6672471" /energy="-14.1" /TU="NA" /idTUdmin="U186" /TUdmin=7 /isTUend="TRUE" /label="downshifts" CDS 265383..265559 /gene="yczK" /locus_tag="BSU_02619" /old_locus_tag="BSU02619" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097673.1" /db_xref="EnsemblGenomes-Gn:BSU02619" /db_xref="EnsemblGenomes-Tr:CAX52543" /db_xref="UniProtKB/Swiss-Prot:C0H3T2" /translation="MGGLQTTGYAENASFSQLSACFSSRLVREDLFLMFSAYNQFTLL HSRLTMISYNGDDQ*" /label="yczK CDS" gene 265383..265559 /gene="yczK" /locus_tag="BSU_02619" /old_locus_tag="BSU02619" /label="yczK gene" promotor_-35 265511..265517 /Source="Nicolas_upshift_promotors" /id="U188" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.942057942057942" /psig="0.056943056943057" /xcortree=6 /SigmaFactorBS="gtttttaatgttcagcgcttacaatcagttcacactTCTTCA CagtcgtTTAACAATGATTTCCTATaatggagacgatcaatgaggagagaggggatct t" /listShort="phoD, tatAD, S99, tatCD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 265524..265541 /Source="Nicolas_upshift_promotors" /id="U188" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.942057942057942" /psig="0.056943056943057" /xcortree=6 /SigmaFactorBS="gtttttaatgttcagcgcttacaatcagttcacactTCTTCA CagtcgtTTAACAATGATTTCCTATaatggagacgatcaatgaggagagaggggatct t" /listShort="phoD, tatAD, S99, tatCD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 265535 /Source="Nicolas_upshifts" /id="U188" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.942057942057942" /psig="0.056943056943057" /xcortree=6 /SigmaFactorBS="gtttttaatgttcagcgcttacaatcagttcacactTCTTCA CagtcgtTTAACAATGATTTCCTATaatggagacgatcaatgaggagagaggggatct t" /listShort="phoD, tatAD, S99, tatCD" /GFF_Attribute="listLong" /label="upshifts" CDS 265578..267329 /gene="phoD" /locus_tag="BSU_02620" /old_locus_tag="BSU02620" /EC_number="3.1.4.46" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11719524, 12867413, 16698798, 19395490, 19616508, 21479178, 27780866" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11719524, 12867413, 16698798, 19395490, 19616508, 21479178, 27780866; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="secreted phosphodiesterase (endo-hydrolysis at non-specific sites throughout the cell wall teichoic acid polymer)" /protein_id="NP_388144.2" /db_xref="EnsemblGenomes-Gn:BSU02620" /db_xref="EnsemblGenomes-Tr:CAB12056" /db_xref="GOA:P42251" /db_xref="InterPro:IPR008963" /db_xref="InterPro:IPR018946" /db_xref="InterPro:IPR029052" /db_xref="InterPro:IPR032093" /db_xref="PDB:2YEQ" /db_xref="SubtiList:BG11174" /db_xref="UniProtKB/Swiss-Prot:P42251" /translation="MAYDSRFDEWVQKLKEESFQNNTFDRRKFIQGAGKIAGLSLGLT IAQSVGAFEVNAAPNFSSYPFTLGVASGDPLSDSVVLWTRLAPDPLNGGGMPKQAVPV KWEVAKDEHFRKIVRKGTEMAKPSLAHSVHVEADGLEPNKVYYYRFKTGHELSPVGKT KTLPAPGANVPQMTFAFASCQQYEHGYYTAYKHMAKEKLDLVFHLGDYIYEYGPNEYV SKTGNVRTHNSAEIITLQDYRNRHAQYRSDANLKAAHAAFPWVVTWDDHEVENNYANK IPEKGQSVEAFVLRRAAAYQAYYEHMPLRISSLPNGPDMQLYRHFTYGNLASFNVLDT RQYRDDQANNDGNKPPSDESRNPNRTLLGKEQEQWLFNNLGSSTAHWNVLAQQIFFAK WNFGTSASPIYSMDSWDGYPAQRERVINFIKSKNLNNVVVLTGDVHASWASNLHVDFE KTSSKIFGAEFVGTSITSGGNGADKRADTDQILKENPHIQFFNDYRGYVRCTVTPHQW KADYRVMPFVTEPGAAISTRASFVYQKDQTGLRKVSSTTIQGGVKQSDEVEEDRFFSH NKAHEKQMIKKRAKITN*" /label="phoD CDS" gene 265578..267329 /gene="phoD" /locus_tag="BSU_02620" /old_locus_tag="BSU02620" /label="phoD gene" promotor_-10 complement(265632..265647) /Source="Nicolas_upshift_promotors" /id="U189" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.875124875124875" /psig="0.875124875124875" /xcortree=1703 /SigmaFactorBS="gagaaagtcctgcaatcttccccgctcctTGAATAAATTtgc ggcggtcaaACGTATTGTTTTGAAAgctttcctctttcagtttctgtacccattcatc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(265638) /Source="Nicolas_upshifts" /id="U189" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.875124875124875" /psig="0.875124875124875" /xcortree=1703 /SigmaFactorBS="gagaaagtcctgcaatcttccccgctcctTGAATAAATTtgc ggcggtcaaACGTATTGTTTTGAAAgctttcctctttcagtttctgtacccattcatc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(265660..265669) /Source="Nicolas_upshift_promotors" /id="U189" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.875124875124875" /psig="0.875124875124875" /xcortree=1703 /SigmaFactorBS="gagaaagtcctgcaatcttccccgctcctTGAATAAATTtgc ggcggtcaaACGTATTGTTTTGAAAgctttcctctttcagtttctgtacccattcatc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 267342..267554 /gene="tatAD" /locus_tag="BSU_02630" /old_locus_tag="BSU02630" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12867413, 15554971, 16678787, 19049517, 21479530, 27984091" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12867413, 15554971, 16678787, 19049517, 21479530, 27984091; Product type t : transporter" /codon_start=1 /transl_table=11 /product="component of the twin-arginine pre-protein translocation pathway" /protein_id="NP_388145.2" /db_xref="EnsemblGenomes-Gn:BSU02630" /db_xref="EnsemblGenomes-Tr:CAB12057" /db_xref="GOA:O31467" /db_xref="InterPro:IPR003369" /db_xref="InterPro:IPR003998" /db_xref="InterPro:IPR006312" /db_xref="PDB:2L16" /db_xref="SubtiList:BG12777" /db_xref="UniProtKB/Swiss-Prot:O31467" /translation="MFSNIGIPGLILIFVIALIIFGPSKLPEIGRAAGRTLLEFKSAT KSLVSGDEKEEKSAELTAVKQDKNAG*" /label="tatAD CDS" gene 267342..267554 /gene="tatAD" /locus_tag="BSU_02630" /old_locus_tag="BSU02630" /label="tatAD gene" S_feature 267555..267614 /Source="Nicolas_S_feature" /locus_tag="new_285988_286047" /HighExp="LPhT, BI, Paraq, C90, H2O2, M40t90, C30, M0t90, GM 60, GM 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.0569" /TUlongSig="NA" /TUlongPSig="NA" /label="S99" CDS 267615..268343 /gene="tatCD" /locus_tag="BSU_02640" /old_locus_tag="BSU02640" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16698798, 19049517, 27984091" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16698798, 19049517, 27984091; Product type t: transporter" /codon_start=1 /transl_table=11 /product="component of the twin-arginine pre-protein translocation pathway" /protein_id="NP_388146.2" /db_xref="EnsemblGenomes-Gn:BSU02640" /db_xref="EnsemblGenomes-Tr:CAB12058" /db_xref="GOA:P42252" /db_xref="InterPro:IPR002033" /db_xref="InterPro:IPR019820" /db_xref="SubtiList:BG11175" /db_xref="UniProtKB/Swiss-Prot:P42252" /translation="MDKKETHLIGHLEELRRRIIVTLAAFFLFLITAFLFVQDIYDWL IRDLDGKLAVLGPSEILWVYMMLSGICAIAASIPVAAYQLWRFVAPALTKTERKVTLM YIPGLFALFLAGISFGYFVLFPIVLSFLTHLSSGHFETMFTADRYFRFMVNLSLPFGF LFEMPLVVMFLTRLGILNPYRLAKARKLSYFLLIVVSILITPPDFISDFLVMIPLLVL FEVSVTLSAFVYKKRMREETAAAA*" /label="tatCD CDS" gene 267615..268343 /gene="tatCD" /locus_tag="BSU_02640" /old_locus_tag="BSU02640" /label="tatCD gene" downshifts complement(267623) /Source="Nicolas_upshifts" /id="D106" /incds=0 /nref=4 /ntot=146 /MaxReadThrough="1.2763" /MaxDrop="3.13944" /score="-9.00478071" /energy="-8.5" /TU="NA" /idTUdmin="U190" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" CDS complement(268340..268987) /gene="pcp" /locus_tag="BSU_02650" /old_locus_tag="BSU02650" /EC_number="3.4.19.3" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1362573, 28830929" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1362573, 28830929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyrrolidone-carboxylate (pyroglutamate) peptidase" /protein_id="NP_388147.1" /db_xref="EnsemblGenomes-Gn:BSU02650" /db_xref="EnsemblGenomes-Tr:CAB12059" /db_xref="GOA:P28618" /db_xref="InterPro:IPR000816" /db_xref="InterPro:IPR016125" /db_xref="InterPro:IPR029762" /db_xref="InterPro:IPR033693" /db_xref="InterPro:IPR033694" /db_xref="InterPro:IPR036440" /db_xref="SubtiList:BG10873" /db_xref="UniProtKB/Swiss-Prot:P28618" /translation="MRKKVLITGFDPFDKETVNPSWEAAKRLNGFETEEAIITAEQIP TVFRSALDTLRQAIQKHQPDIVICVGQAGGRMQITPERVAINLADARIPDNEGHQPID EEISPDGPAAYWTRLPVKRMTAKMKEHGIPAAVSYTAGTFVCNYLFYGLMDHISRTSP HIRGGFIHIPYIPQQTIDKTAPSLSLDTIVRALRIAAVTAAQYDEDVKSPGGTLH*" /label="pcp CDS" gene complement(268340..268987) /gene="pcp" /locus_tag="BSU_02650" /old_locus_tag="BSU02650" /label="pcp gene" promotor_-10 complement(269002..269021) /Source="Nicolas_upshift_promotors" /id="U190" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.487512487512487" /psig="0.957042957042957" /xcortree=559 /SigmaFactorBS="aaatgctccattatgattcactcctttacattatttTGATGa aaaacccataaatAAACAATAGAATAAAAGAAAaaggagatgggagaatgagaaaaaa a" /listShort="pcp" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 269015..269021 /Source="Nicolas_upshift_promotors" /id="U191" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.603396603396603" /psig="0.988011988011988" /xcortree=2718 /SigmaFactorBS="tttttctcattctcccatctcctttttcttttattctATTGT TTatttatgggtttttCATCAAAATAATGTAAAGGAgtgaatcataatggagcatttg c" /listShort="ycbU" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(269016) /Source="Nicolas_upshifts" /id="U190" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.487512487512487" /psig="0.957042957042957" /xcortree=559 /SigmaFactorBS="aaatgctccattatgattcactcctttacattatttTGATGa aaaacccataaatAAACAATAGAATAAAAGAAAaaggagatgggagaatgagaaaaaa a" /listShort="pcp" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(269036..269040) /Source="Nicolas_upshift_promotors" /id="U190" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.487512487512487" /psig="0.957042957042957" /xcortree=559 /SigmaFactorBS="aaatgctccattatgattcactcctttacattatttTGATGa aaaacccataaatAAACAATAGAATAAAAGAAAaaggagatgggagaatgagaaaaaa a" /listShort="pcp" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 269036..269055 /Source="Nicolas_upshift_promotors" /id="U191" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.603396603396603" /psig="0.988011988011988" /xcortree=2718 /SigmaFactorBS="tttttctcattctcccatctcctttttcttttattctATTGT TTatttatgggtttttCATCAAAATAATGTAAAGGAgtgaatcataatggagcatttg c" /listShort="ycbU" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 269038 /Source="Nicolas_upshifts" /id="U191" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.603396603396603" /psig="0.988011988011988" /xcortree=2718 /SigmaFactorBS="tttttctcattctcccatctcctttttcttttattctATTGT TTatttatgggtttttCATCAAAATAATGTAAAGGAgtgaatcataatggagcatttg c" /listShort="ycbU" /GFF_Attribute="listLong" /label="upshifts" CDS 269066..270178 /gene="ycbU" /locus_tag="BSU_02660" /old_locus_tag="BSU02660" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative lyase (PLP-dependent)" /protein_id="NP_388148.2" /db_xref="EnsemblGenomes-Gn:BSU02660" /db_xref="EnsemblGenomes-Tr:CAB12060" /db_xref="GOA:P42253" /db_xref="InterPro:IPR000192" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR020578" /db_xref="SubtiList:BG11176" /db_xref="UniProtKB/Swiss-Prot:P42253" /translation="MEHLPEQYRQLFPTLQTHTMLASCSQSALAEPVSRAIQDYYDSL LYKGTNWKEAIEKTEFARNEFAKLIGAEPDEVAIVPSVSDALVSVASSLTAFGKKHVV YTDMDFPAVPHVWQAHSDYTVSVIPSIDGVLPLEQYETHISDETVLTCVPHVHYRDGY VQDIKAIAEISQRKGSLLFVDAYQSAGHIPIDVKEWGVDMLAAGTRKYLLGIPGVAFL YVRKELADALKPKASAWFGRESGFDGAYAKVARRFQTGTPAFISVYAAAAALSLLNHI GVSHIRDHVKTICADAVQYAAEKGLQLAAAQGGIQPGMVAIRDERASETAGLLKKKKV ICAPRENVIRLAPHFYNTKEEMRHAIDEIAAKTIHK*" /label="ycbU CDS" gene 269066..270178 /gene="ycbU" /locus_tag="BSU_02660" /old_locus_tag="BSU02660" /label="ycbU gene" upshifts complement(269412) /Source="Nicolas_upshifts" /id="U192" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=2851 /SigmaFactorBS="tcaagcggcagcacgccgTCTATtgatggaatgacggaTACG GTATAATCGGAGTGTGcctgccaaacatgaggcaccgccggaaaatccatatctgtat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(269415..269434) /Source="Nicolas_upshift_promotors" /id="U192" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=2851 /SigmaFactorBS="tcaagcggcagcacgccgTCTATtgatggaatgacggaTACG GTATAATCGGAGTGTGcctgccaaacatgaggcaccgccggaaaatccatatctgtat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(269450..269454) /Source="Nicolas_upshift_promotors" /id="U192" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=2851 /SigmaFactorBS="tcaagcggcagcacgccgTCTATtgatggaatgacggaTACG GTATAATCGGAGTGTGcctgccaaacatgaggcaccgccggaaaatccatatctgtat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 270172 /Source="Nicolas_upshifts" /id="D107" /incds=0 /nref=45 /ntot=226 /MaxReadThrough="1.10091" /MaxDrop="4.52742" /score="6.75687898" /energy="-14" /TU="NA" /idTUdmin="U191" /TUdmin=814 /isTUend="FALSE" /label="downshifts" CDS complement(270220..271659) /gene="lmrB" /locus_tag="BSU_02670" /old_locus_tag="BSU02670" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15317768, 15849754, 16850406, 17483215" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15317768, 15849754, 16850406, 17483215; Product type t: transporter" /codon_start=1 /transl_table=11 /product="flavonoid efflux transporter; drug-export protein" /protein_id="NP_388149.1" /db_xref="EnsemblGenomes-Gn:BSU02670" /db_xref="EnsemblGenomes-Tr:CAB12061" /db_xref="GOA:O35018" /db_xref="InterPro:IPR004638" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12613" /db_xref="UniProtKB/Swiss-Prot:O35018" /translation="MILETTAKASQQYKVMPIMISLLLAGFIGMFSETALNIALTDLM KELNITAATVQWLTTGYLLVLGILVPVSGLLLQWFTTRQLFTVSLIFSILGTFIAALA PSFSFLLAARIVQALGTGLLLPLMFNTILVIFPPHKRGAAMGTIGLVIMFAPAIGPTF SGLVLEHLNWHWIFWISLPFLVLALVFGIAYMQNVSETTKPKIDVLSIILSTIGFGGI VFGFSNAGEGSGGWSSPTVIVSLIVGVVGLILFSIRQLTMKQPMMNLRAFKYPMFILG VIMVFICMMVILSSMLLLPMYLQGGLVLTAFASGLVLLPGGILNGFMSPVTGRLFDKY GPKWLVIPGFVIVTVVLWFFSNVTTTSTAVLIIILHTCLMIGISMIMMPAQTNGLNQL PREFYPDGTAIMNTLQQMAGAIGTAVAVSIMAAGQHDYMSTVKNPADPAVIPQALTAG VQHAFVFAMIVAIIGLIGAFFMKRVKVDH*" /label="lmrB CDS" gene complement(270220..271659) /gene="lmrB" /locus_tag="BSU_02670" /old_locus_tag="BSU02670" /label="lmrB gene" downshifts complement(270227) /Source="Nicolas_upshifts" /id="D108" /incds=0 /nref=162 /ntot=245 /MaxReadThrough="0.65833" /MaxDrop="6.75228" /score="18.3484535" /energy="-14" /TU="U193" /idTUdmin="U193" /TUdmin="-23" /isTUend="FALSE" /label="downshifts" CDS complement(271699..272265) /gene="lmrA" /locus_tag="BSU_02680" /old_locus_tag="BSU02680" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12718394, 15317768, 17483215" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12718394, 15317768, 17483215; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of lmrAB and yxaGH operons (flavonoid and antibiotic resistance)" /protein_id="NP_388150.1" /db_xref="EnsemblGenomes-Gn:BSU02680" /db_xref="EnsemblGenomes-Tr:CAB12062" /db_xref="GOA:O34619" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036271" /db_xref="SubtiList:BG12612" /db_xref="UniProtKB/Swiss-Prot:O34619" /translation="MSYGDSREKILSAATRLFQLQGYYGTGLNQIIKESGAPKGSLYY HFPGGKEQLAIEAVNEMKEYIRQKIADCMEACTDPAEGIQAFLKELSCQFSCTEDIEG LPVGLLAAETSLKSEPLREACHEAYKEWASVYEEKLRQTGCSESRAKEASTVVNAMIE GGILLSLTAKNSTPLLHISSCIPDLLKR*" /label="lmrA CDS" gene complement(271699..272265) /gene="lmrA" /locus_tag="BSU_02680" /old_locus_tag="BSU02680" /label="lmrA gene" promotor_-10 complement(272303..272322) /Source="Nicolas_upshift_promotors" /id="U193" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2398 /SigmaFactorBS="cttctttttttgtcttttcatacaatgaattttTCTTGACAa ttgatgattgaatCAAGATAATAGACCAGTCACtatatttttgattgcaattcagtaa g" /listShort="lmrA, lmrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(272317) /Source="Nicolas_upshifts" /id="U193" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2398 /SigmaFactorBS="cttctttttttgtcttttcatacaatgaattttTCTTGACAa ttgatgattgaatCAAGATAATAGACCAGTCACtatatttttgattgcaattcagtaa g" /listShort="lmrA, lmrB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(272337..272344) /Source="Nicolas_upshift_promotors" /id="U193" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2398 /SigmaFactorBS="cttctttttttgtcttttcatacaatgaattttTCTTGACAa ttgatgattgaatCAAGATAATAGACCAGTCACtatatttttgattgcaattcagtaa g" /listShort="lmrA, lmrB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 272419..272425 /Source="Nicolas_upshift_promotors" /id="U194" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.368631368631369" /psig="0.652347652347652" /xcortree=316 /SigmaFactorBS="acaaaaaatactgagagaaaagctgactgatcTTTTGACtga atagataaaatgTACAATGATTAATCATCAtatggatgtaaggagagaaatagatgaa a" /listShort="ansZ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 272441..272458 /Source="Nicolas_upshift_promotors" /id="U194" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.368631368631369" /psig="0.652347652347652" /xcortree=316 /SigmaFactorBS="acaaaaaatactgagagaaaagctgactgatcTTTTGACtga atagataaaatgTACAATGATTAATCATCAtatggatgtaaggagagaaatagatgaa a" /listShort="ansZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 272447 /Source="Nicolas_upshifts" /id="U194" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.368631368631369" /psig="0.652347652347652" /xcortree=316 /SigmaFactorBS="acaaaaaatactgagagaaaagctgactgatcTTTTGACtga atagataaaatgTACAATGATTAATCATCAtatggatgtaaggagagaaatagatgaa a" /listShort="ansZ" /GFF_Attribute="listLong" /label="upshifts" CDS 272482..273609 /gene="ansZ" /locus_tag="BSU_02690" /old_locus_tag="BSU02690" /EC_number="3.5.1.1" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11914346, 17686772" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11914346, 17686772; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-asparaginase 2 (putative lipoprotein)" /protein_id="NP_388151.1" /db_xref="EnsemblGenomes-Gn:BSU02690" /db_xref="EnsemblGenomes-Tr:CAB12063" /db_xref="GOA:O34482" /db_xref="InterPro:IPR004550" /db_xref="InterPro:IPR006034" /db_xref="InterPro:IPR020827" /db_xref="InterPro:IPR027473" /db_xref="InterPro:IPR027474" /db_xref="InterPro:IPR027475" /db_xref="InterPro:IPR036152" /db_xref="InterPro:IPR037152" /db_xref="SubtiList:BG12755" /db_xref="UniProtKB/Swiss-Prot:O34482" /translation="MKKQRMLVLFTALLFVFTGCSHSPETKESPKEKAQTQKVSSASA SEKKDLPNIRILATGGTIAGADQSKTSTTEYKAGVVGVESLIEAVPEMKDIANVSGEQ IVNVGSTNIDNKILLKLAKRINHLLASDDVDGIVVTHGTDTLEETAYFLNLTVKSDKP VVIVGSMRPSTAISADGPSNLYNAVKVAGAPEAKGKGTLVVLNDRIASARYVTKTNTT TTDTFKSEEMGFVGTIADDIYFNNEITRKHTKDTDFSVSNLDELPQVDIIYGYQNDGS YLFDAAVKAGAKGIVFAGSGNGSLSDAAEKGADSAVKKGVTVVRSTRTGNGVVTPNQD YAEKDLLASNSLNPQKARMLLMLALTKTNDPQKIQAYFNEY*" /label="ansZ CDS" gene 272482..273609 /gene="ansZ" /locus_tag="BSU_02690" /old_locus_tag="BSU02690" /label="ansZ gene" downshifts 273582 /Source="Nicolas_upshifts" /id="D109" /incds=0 /nref=3 /ntot=26 /MaxReadThrough="1.70459" /MaxDrop="4.27333" /score="23.2201078" /energy="-7.6" /TU="NA" /idTUdmin="U194" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 273706..273712 /Source="Nicolas_upshift_promotors" /id="U195" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.455544455544456" /psig=1 /xcortree=3077 /SigmaFactorBS="tctgaatcttaaaatttctttaaaaataagccaaaattacCC TTTACttaattaatttggTAACGTAATATAATTGGAGAatttgttacaaaaaaaggag g" /listShort="estA, S100, yccF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 273726..273745 /Source="Nicolas_upshift_promotors" /id="U195" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.455544455544456" /psig=1 /xcortree=3077 /SigmaFactorBS="tctgaatcttaaaatttctttaaaaataagccaaaattacCC TTTACttaattaatttggTAACGTAATATAATTGGAGAatttgttacaaaaaaaggag g" /listShort="estA, S100, yccF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 273726 /Source="Nicolas_upshifts" /id="U195" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.455544455544456" /psig=1 /xcortree=3077 /SigmaFactorBS="tctgaatcttaaaatttctttaaaaataagccaaaattacCC TTTACttaattaatttggTAACGTAATATAATTGGAGAatttgttacaaaaaaaggag g" /listShort="estA, S100, yccF" /GFF_Attribute="listLong" /label="upshifts" CDS 273772..274410 /gene="estA" /locus_tag="BSU_02700" /old_locus_tag="BSU02700" /EC_number="3.1.1.3" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8396026, 15812018, 18053819, 11029590, 24827611, 28963005" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8396026, 15812018, 18053819, 11029590, 24827611, 28963005; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="secreted alkaliphilic lipase" /protein_id="NP_388152.1" /db_xref="EnsemblGenomes-Gn:BSU02700" /db_xref="EnsemblGenomes-Tr:CAB12064" /db_xref="GOA:P37957" /db_xref="InterPro:IPR002918" /db_xref="InterPro:IPR029058" /db_xref="PDB:1I6W" /db_xref="PDB:1ISP" /db_xref="PDB:1R4Z" /db_xref="PDB:1R50" /db_xref="PDB:1T2N" /db_xref="PDB:1T4M" /db_xref="PDB:2QXT" /db_xref="PDB:2QXU" /db_xref="PDB:3D2A" /db_xref="PDB:3D2B" /db_xref="PDB:3D2C" /db_xref="PDB:3QMM" /db_xref="PDB:3QZU" /db_xref="PDB:5CRI" /db_xref="PDB:5CT4" /db_xref="PDB:5CT5" /db_xref="PDB:5CT6" /db_xref="PDB:5CT8" /db_xref="PDB:5CT9" /db_xref="PDB:5CTA" /db_xref="PDB:5CUR" /db_xref="SubtiList:BG10679" /db_xref="UniProtKB/Swiss-Prot:P37957" /translation="MKFVKRRIIALVTILMLSVTSLFALQPSAKAAEHNPVVMVHGIG GASFNFAGIKSYLVSQGWSRDKLYAVDFWDKTGTNYNNGPVLSRFVQKVLDETGAKKV DIVAHSMGGANTLYYIKNLDGGNKVANVVTLGGANRLTTGKALPGTDPNQKILYTSIY SSADMIVMNYLSRLDGARNVQIHGVGHIGLLYSSQVNSLIKEGLNGGGQNTN*" /label="estA CDS" gene 273772..274410 /gene="estA" /locus_tag="BSU_02700" /old_locus_tag="BSU02700" /label="estA gene" downshifts 274396 /Source="Nicolas_upshifts" /id="D110" /incds=0 /nref=15 /ntot=117 /MaxReadThrough="4.54554" /MaxDrop="4.10395" /score="23.2201078" /energy="-7.6" /TU="U195" /idTUdmin="U194" /TUdmin=814 /isTUend="FALSE" /label="downshifts" S_feature 274441..275031 /Source="Nicolas_S_feature" /locus_tag="new_292874_293464" /HighExp="M9-tran, GM 150, LoTm, MG 150, GM 120, aero, T-1.40H, M/G, S2, GM 90" /AntisenseName="yczC" /AntisenseCor="3.5651747957185502E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S100" CDS complement(274448..274831) /gene="yczC" /locus_tag="BSU_02710" /old_locus_tag="BSU02710" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406; Product type m:membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein of unknown function" /protein_id="NP_388153.1" /db_xref="EnsemblGenomes-Gn:BSU02710" /db_xref="EnsemblGenomes-Tr:CAB12065" /db_xref="GOA:O31469" /db_xref="InterPro:IPR010432" /db_xref="SubtiList:BG12778" /db_xref="UniProtKB/Swiss-Prot:O31469" /translation="MELAGFMLRACALLLDVIIAAAVILAAGFTFGDGSAGVIIVAIL MLIVYPLLMPLTNWKGTLGKKIIGLQIVRDETYKKISFPQAIVRYLIAWVHVFSRLIY LTAAFTKKKQTVHDMAAKTIVLKAE*" /label="yczC CDS" gene complement(274448..274831) /gene="yczC" /locus_tag="BSU_02710" /old_locus_tag="BSU02710" /label="yczC gene" downshifts complement(274472) /Source="Nicolas_upshifts" /id="D111" /incds=0 /nref=4 /ntot=94 /MaxReadThrough="0.85389" /MaxDrop="2.7858" /score="15.0330092" /energy="-12.1" /TU="NA" /idTUdmin="U196" /TUdmin=0 /isTUend="TRUE" /label="downshifts" Polymorphism join(274645,274647) /Source="geneious" /ID="SNP_BsDelta6_293079_293079" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change /CDS_Position=186 /Change="C -> T" /Codon_Change="CTG -> CTA" /Coverage=154 /locus_tag="BSU_02710" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="C" /Variant_Nucleotides="T" /Variant_P_Value=0 /Variant_Raw_Frequency=154 /comment="silent" /modified_by="User" / /label="Polymorphism_Delta6" promotor_-10 complement(274861..274880) /Source="Nicolas_upshift_promotors" /id="U196" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.507492507492508" /psig="0.835164835164835" /xcortree=3082 /SigmaFactorBS="aacttttgtgatttaaggcttatcaccTATTCCCActttagg cccttcTTTTTTACAATCATTAGGTGtttatttaacattttaaggagtgtttctattg g" /listShort="yczC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(274868) /Source="Nicolas_upshifts" /id="U196" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.507492507492508" /psig="0.835164835164835" /xcortree=3082 /SigmaFactorBS="aacttttgtgatttaaggcttatcaccTATTCCCActttagg cccttcTTTTTTACAATCATTAGGTGtttatttaacattttaaggagtgtttctattg g" /listShort="yczC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(274894..274901) /Source="Nicolas_upshift_promotors" /id="U196" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.507492507492508" /psig="0.835164835164835" /xcortree=3082 /SigmaFactorBS="aacttttgtgatttaaggcttatcaccTATTCCCActttagg cccttcTTTTTTACAATCATTAGGTGtttatttaacattttaaggagtgtttctattg g" /listShort="yczC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 275003..275006 /Source="Nicolas_upshift_promotors" /id="U197" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.916083916083916" /psig="0.999000999001" /xcortree=2575 /SigmaFactorBS="acattaccaaattcttttttagcccgaaacCAAGccctcaga agttattTTTGTTAAAATAGAAAAGTTacaacagaattcggagggtttattgtgggaa a" /listShort="yccF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 275022..275041 /Source="Nicolas_upshift_promotors" /id="U197" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.916083916083916" /psig="0.999000999001" /xcortree=2575 /SigmaFactorBS="acattaccaaattcttttttagcccgaaacCAAGccctcaga agttattTTTGTTAAAATAGAAAAGTTacaacagaattcggagggtttattgtgggaa a" /listShort="yccF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 275033 /Source="Nicolas_upshifts" /id="U197" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.916083916083916" /psig="0.999000999001" /xcortree=2575 /SigmaFactorBS="acattaccaaattcttttttagcccgaaacCAAGccctcaga agttattTTTGTTAAAATAGAAAAGTTacaacagaattcggagggtttattgtgggaa a" /listShort="yccF" /GFF_Attribute="listLong" /label="upshifts" CDS 275066..276142 /gene="yccF" /locus_tag="BSU_02720" /old_locus_tag="BSU02720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388154.1" /db_xref="EnsemblGenomes-Gn:BSU02720" /db_xref="EnsemblGenomes-Tr:CAB12066" /db_xref="GOA:O34478" /db_xref="InterPro:IPR004027" /db_xref="InterPro:IPR007889" /db_xref="InterPro:IPR036915" /db_xref="SubtiList:BG12756" /db_xref="UniProtKB/Swiss-Prot:O34478" /translation="MGKVKRNAPCPCGSGKKYKKCCGSKVVDFPAELAAKEAKQIQED LVEYAFTVHRESISGFINQHDFLSAMDRQTKDISVFNLGIWGIFFHPLAGEKTIFEEY LQKKGDSITRPKTREIVESWQSMTPALLLLKDLKEGIIHFEDVITAKQFEVEMDASNQ DLPPVGSLILGYPIHEAEKAEFFMQFTIFPVKRTEALISKVKKYADAAVKDGKTPEDF MKQEFNNVLFALLAEKDEEPQAEKAEVSTVEWANDLEKETAAAIEEGMSGEEYPTELI PAVIDIWKTFCEKKSPVIRKPEAFAAAVEYYVNAISLNGASVSQAKLAKKYGVSASTI SSRYKEIESTLQDEADRFAQALSS*" /label="yccF CDS" gene 275066..276142 /gene="yccF" /locus_tag="BSU_02720" /old_locus_tag="BSU02720" /label="yccF gene" downshifts 276136 /Source="Nicolas_upshifts" /id="D112" /incds=0 /nref=60 /ntot=248 /MaxReadThrough="1.55048" /MaxDrop="5.18328" /score="33.0000484" /energy="-12.9" /TU="NA" /idTUdmin="U197" /TUdmin=2 /isTUend="TRUE" /label="downshifts" CDS complement(276182..277138) /gene="natK" /locus_tag="BSU_02730" /old_locus_tag="BSU02730" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295, 17322186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 17322186; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [NatR]" /protein_id="NP_388155.1" /db_xref="EnsemblGenomes-Gn:BSU02730" /db_xref="EnsemblGenomes-Tr:CAB12067" /db_xref="GOA:P70954" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR032834" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG11997" /db_xref="UniProtKB/Swiss-Prot:P70954" /translation="MITLFQCLYLILFSFICYQGAAAFSHSTAASWLAAALGAAAAGL YIWNTKRVWKHCSSGLCAWIAVIQVMSVGVVLIGTDIMPVLCVIAIFAGCEGLRIGQS ALQARLSDQIDKLTQAEQHANQMLIDVRSRNHDTMKHITAIKSAQPKADTQAYIQNWA DQYSQYDRFLKGENAYVAGVLYDFLEKARASNVSVSLHMHTPLSSLPFSPADQVSLVG NILENALDSAAEAREKAEIKLETSLRSGLYVLTCENSTPGMDPKVLDTIYQSFGRSTK NGAHEGMGTYIIQKLVKGAFGRLDFTYRHPIFRLEIKIPFQK*" /label="natK CDS" gene complement(276182..277138) /gene="natK" /locus_tag="BSU_02730" /old_locus_tag="BSU02730" /label="natK gene" downshifts complement(276210) /Source="Nicolas_upshifts" /id="D113" /incds=0 /nref=1 /ntot=129 /MaxReadThrough="0.86926" /MaxDrop="2.67125" /score="14.02819" /energy="-12.9" /TU="NA" /idTUdmin="U198" /TUdmin=176 /isTUend="FALSE" /label="downshifts" CDS complement(277151..277852) /gene="natR" /locus_tag="BSU_02740" /old_locus_tag="BSU02740" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 17322186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 17322186; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [NatK]" /protein_id="NP_388156.1" /db_xref="EnsemblGenomes-Gn:BSU02740" /db_xref="EnsemblGenomes-Tr:CAB12068" /db_xref="GOA:P70955" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR007492" /db_xref="InterPro:IPR011006" /db_xref="SubtiList:BG11998" /db_xref="UniProtKB/Swiss-Prot:P70955" /translation="MVKVGLVDDYRVDLEKLEAIVSRMQDVEIVFSTDSAKEAYRRVK NGDIDLLLADIEMPHMSGYELADLIKSHSLDVDVIFVTGHGGYAVHAFDLNVHDYIMK PYYADRLAASFDRYLKKKTETSLNGRILIKQKSEMHVLQKKDIIFAERTGRSTTIVTT AEEVQTYQTLNDIKGDLPEKDFLRSHRSFIINIHYIKHFSAYTKHSFTVSFEGTSKKA MITKQQLDYFQNYYF*" /label="natR CDS" gene complement(277151..277852) /gene="natR" /locus_tag="BSU_02740" /old_locus_tag="BSU02740" /label="natR gene" promotor_-10 complement(277876..277895) /Source="Nicolas_upshift_promotors" /id="U198" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.397602397602398" /psig="0.992007992007992" /xcortree=2173 /SigmaFactorBS="attagttggataaagttgtcgcgaagagTTCTttttatgtcg tgaaaTGGGATAGAATAAAGATGATtctatgtaactaggggaatgataatggtaaaag t" /listShort="natR, natK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(277882) /Source="Nicolas_upshifts" /id="U198" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.397602397602398" /psig="0.992007992007992" /xcortree=2173 /SigmaFactorBS="attagttggataaagttgtcgcgaagagTTCTttttatgtcg tgaaaTGGGATAGAATAAAGATGATtctatgtaactaggggaatgataatggtaaaag t" /listShort="natR, natK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(277911..277914) /Source="Nicolas_upshift_promotors" /id="U198" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.397602397602398" /psig="0.992007992007992" /xcortree=2173 /SigmaFactorBS="attagttggataaagttgtcgcgaagagTTCTttttatgtcg tgaaaTGGGATAGAATAAAGATGATtctatgtaactaggggaatgataatggtaaaag t" /listShort="natR, natK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 277932..277935 /Source="Nicolas_upshift_promotors" /id="U199" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.356643356643357" /psig="0.844155844155844" /xcortree=1785 /SigmaFactorBS="cgacataaaaagaactcttcgcgacaactttATCCaactaat ccagctttTCGTATATAGTCATTACTAGaaataaagataagggagattgtgacatgat t" /listShort="natA, natB, yccK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 277951..277970 /Source="Nicolas_upshift_promotors" /id="U199" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.356643356643357" /psig="0.844155844155844" /xcortree=1785 /SigmaFactorBS="cgacataaaaagaactcttcgcgacaactttATCCaactaat ccagctttTCGTATATAGTCATTACTAGaaataaagataagggagattgtgacatgat t" /listShort="natA, natB, yccK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 277961 /Source="Nicolas_upshifts" /id="U199" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.356643356643357" /psig="0.844155844155844" /xcortree=1785 /SigmaFactorBS="cgacataaaaagaactcttcgcgacaactttATCCaactaat ccagctttTCGTATATAGTCATTACTAGaaataaagataagggagattgtgacatgat t" /listShort="natA, natB, yccK" /GFF_Attribute="listLong" /label="upshifts" CDS 277996..278736 /gene="natA" /locus_tag="BSU_02750" /old_locus_tag="BSU02750" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10356997, 17322186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10356997, 17322186; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Na+ ABC efflux transporter (ATP-binding protein)" /protein_id="NP_388157.1" /db_xref="EnsemblGenomes-Gn:BSU02750" /db_xref="EnsemblGenomes-Tr:CAB12069" /db_xref="GOA:P46903" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11338" /db_xref="UniProtKB/Swiss-Prot:P46903" /translation="MITLTDCSRRFQDKKKVVKAVRDVSLTIEKGEVVGILGENGAGK TTMLRMIASLLEPSQGVITVDGFDTVKQPAEVKQRIGVLFGGETGLYDRMTAKENLQY FGRLYGLNRHEIKARIEDLSKRFGMRDYMNRRVGGFSKGMRQKVAIARALIHDPDIIL FDEPTTGLDITSSNIFREFIQQLKREQKTILFSSHIMEEVQALCDSVIMIHSGEVIYR GALESLYESERSEDLNYIFMSKLVRGIS*" /label="natA CDS" gene 277996..278736 /gene="natA" /locus_tag="BSU_02750" /old_locus_tag="BSU02750" /label="natA gene" CDS 278737..279897 /gene="natB" /locus_tag="BSU_02760" /old_locus_tag="BSU02760" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10356997, 15849754, 16850406, 17322186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10356997, 15849754, 16850406, 17322186; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Na+ ABC efflux transporter (permease)" /protein_id="NP_388158.1" /db_xref="EnsemblGenomes-Gn:BSU02760" /db_xref="EnsemblGenomes-Tr:CAB12070" /db_xref="GOA:P46904" /db_xref="InterPro:IPR032688" /db_xref="SubtiList:BG11339" /db_xref="UniProtKB/Swiss-Prot:P46904" /translation="MLSHIYKKEMIDALRDRKTILLTILVPMIMMLGLVFFYESMLSD KGEQYTLAVGHSLPPALESKLNEIDEISVKTFAKPEEAVDEGKADAYLNVPKEFDSYV NSMTPFKVDVYGNSIDQGSSNAMQLVQSALDQYKNEIVQQRLTNKHIDQSVIQPFTIQ QKEADEEKGTSAIMLSAILPMLILTSIVSGAMPIALDIMAGEKDRKSIEALLLTPVSR NKVLVGKWLAVSTFGVASGVFALVFLILSTVLFTENLKTAFQLGDHMWSVIGASALII VLSALLISAMELFISIMSSSVKEAQSYMSLVVFLPVFPMFFIFSKAPNQFDLSYFLIP FLNLHALFKQLLFGMVDPATILSTSGTIAVLIAIFFLLARACFLKDKWVLPK*" /label="natB CDS" gene 278737..279897 /gene="natB" /locus_tag="BSU_02760" /old_locus_tag="BSU02760" /label="natB gene" promotor_-35 279948..279956 /Source="Nicolas_upshift_promotors" /id="U200" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=430 /SigmaFactorBS="ggagaaatacactttctcctttttgtatatcctgaaaaaaGA AGGAAAAtagaaaaaggaTATCTAATACAAAAAGTGAccctgcactatttttcatcaa a" /listShort="yccK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 279968..279986 /Source="Nicolas_upshift_promotors" /id="U200" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=430 /SigmaFactorBS="ggagaaatacactttctcctttttgtatatcctgaaaaaaGA AGGAAAAtagaaaaaggaTATCTAATACAAAAAGTGAccctgcactatttttcatcaa a" /listShort="yccK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 279968 /Source="Nicolas_upshifts" /id="U200" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=430 /SigmaFactorBS="ggagaaatacactttctcctttttgtatatcctgaaaaaaGA AGGAAAAtagaaaaaggaTATCTAATACAAAAAGTGAccctgcactatttttcatcaa a" /listShort="yccK" /GFF_Attribute="listLong" /label="upshifts" CDS 280033..280965 /gene="yccK" /locus_tag="BSU_02770" /old_locus_tag="BSU02770" /EC_number="1.-.-.-" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17322186, 24330391; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ion channel associated aldo-keto reductase" /protein_id="NP_388159.1" /db_xref="EnsemblGenomes-Gn:BSU02770" /db_xref="EnsemblGenomes-Tr:CAB12071" /db_xref="GOA:P46905" /db_xref="InterPro:IPR020471" /db_xref="InterPro:IPR023210" /db_xref="InterPro:IPR036812" /db_xref="SubtiList:BG11340" /db_xref="UniProtKB/Swiss-Prot:P46905" /translation="MDQTRTLGKTKLKVKRIGFGANAVGGHNLFPNLNDETGKDLVRT ALDGGVNFIDTAFIYGLGRSEELIGEVVQERGVRNELIIATKGAHKEVDGSIELDNSR EFLRSEVEKSLKRLKTDYIDLYYVHFPDGKTPLAEVAGTLKELKDEGKIKAIGASNLD YQQLQDFNADGYLEVFQAEYSLIQRDAEKELLPYCEKQGISFIPYFPLASGLLTGKFT QDTVFDDFRKDKPQFQGETFIHNLKKVDKLKAVAEEKQADTAHVALAWLLTRPAIDAI IPGAKRPEQLQDNLKTLNIELTEDEVNFISDIFK*" /label="yccK CDS" gene 280033..280965 /gene="yccK" /locus_tag="BSU_02770" /old_locus_tag="BSU02770" /label="yccK gene" CDS complement(281005..282069) /gene="ycdA" /locus_tag="BSU_02780" /old_locus_tag="BSU02780" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 22496484; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="lipoprotein involved in swarming behaviour" /protein_id="NP_388160.1" /db_xref="EnsemblGenomes-Gn:BSU02780" /db_xref="EnsemblGenomes-Tr:CAB12072" /db_xref="GOA:O34538" /db_xref="InterPro:IPR029050" /db_xref="InterPro:IPR029051" /db_xref="InterPro:IPR031343" /db_xref="PDB:4R4G" /db_xref="SubtiList:BG12757" /db_xref="UniProtKB/Swiss-Prot:O34538" /translation="MFQKKTYAVFLILLLMMFTAACSGSKTSAEKKESETEKSSDIAQ VKIKDVSYTLPSKYDKSTSDDQLVLKVNVAVKNTGKDPLNVDSMDFTLYQGDTKMSDT DPEDYSEKLQGSTINADKSVEGNLFFVVDKGKQYELNYTPESYGDKKPKSVTFKIDGK DKKILATADKLQDSAKALSAYVDVLLFGKDNADFEKITGANKNEIVNDFNESAKDGYL SASGLSSTYADSKALDNIVNGIKEGLSKNSSIQAKTTSISKDEAIVEATVKPVDASSL SDRIEDKVKDYYSKNSSASYEEAVKYALQVYPEEFKKLGPASSEKTVEVKMKKNDIDQ WQLDMDDYRAAELVEAFIKE*" /label="ycdA CDS" gene complement(281005..282069) /gene="ycdA" /locus_tag="BSU_02780" /old_locus_tag="BSU02780" /label="ycdA gene" downshifts complement(281006) /Source="Nicolas_upshifts" /id="D114" /incds=0 /nref=198 /ntot=222 /MaxReadThrough="0.57029" /MaxDrop="8.85093" /score="27.0612397" /energy="-13.7" /TU="NA" /idTUdmin="U201" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(282070..282260) /Source="Nicolas_S_feature" /locus_tag="new_300503_300693_c" /HighExp="S5, S4, MG 45, MG 15, MG-0.2, MG 25, MG-0.1, MG 10, S3, MG t5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S101" CDS complement(282092..282223) /locus_tag="BSU_02785" /old_locus_tag="BSU02785" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513941.1" /translation="MTKEGGVSRKSGENREKRTDFFGYMMLIHSKRSISQRQKTPLS* " /label="hypothetical protein CDS" gene complement(282092..282223) /locus_tag="BSU_02785" /old_locus_tag="BSU02785" /label="gene" promotor_-10 complement(282245..282264) /Source="Nicolas_upshift_promotors" /id="U201" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.997002997002997" /xcortree=2915 /SigmaFactorBS="ttaccagaacatttttcaccaaaaataggatgatgaaccTAT TCAATataaaagctaataaTCTTAAAATTAATTCCGTTGtaactttttataggtccat t" /listShort="S101, ycdA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(282265) /Source="Nicolas_upshifts" /id="U201" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.997002997002997" /xcortree=2915 /SigmaFactorBS="ttaccagaacatttttcaccaaaaataggatgatgaaccTAT TCAATataaaagctaataaTCTTAAAATTAATTCCGTTGtaactttttataggtccat t" /listShort="S101, ycdA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(282279..282286) /Source="Nicolas_upshift_promotors" /id="U201" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.997002997002997" /xcortree=2915 /SigmaFactorBS="ttaccagaacatttttcaccaaaaataggatgatgaaccTAT TCAATataaaagctaataaTCTTAAAATTAATTCCGTTGtaactttttataggtccat t" /listShort="S101, ycdA" /GFF_Attribute="listLong" /label="promotor_-35" CDS 282397..283815 /gene="ycdB" /locus_tag="BSU_02790" /old_locus_tag="BSU02790" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388161.1" /db_xref="EnsemblGenomes-Gn:BSU02790" /db_xref="EnsemblGenomes-Tr:CAB12073" /db_xref="InterPro:IPR032599" /db_xref="SubtiList:BG12758" /db_xref="UniProtKB/Swiss-Prot:O34621" /translation="MKGAAFVKKEGLKQKALEIGRVPTHLKLEIEDYGGDDKRAHFCW ADPQDENTGIIVELGPDGELESLSRDIEPESGERLSEEKLEDIMRQFVETHHPGALSA FVREENDRAYGDKVRFSYVQMEAGLPLPMSGFMADVSLSGEIVYFRYYGEAGSIIKPK RVADVEEALAFIKKDVEFDLLFEVLHRSVYKNGDDQPHLVYEPEGRAITVPADLVQEE QAVDDDDDYREPESFPLPLFEGIREKADPDSMIGIENGFVKEREADLGDGRIGIVWRN PDDPVYQPADKSMDSWFKGRTHQVLKTIYNKETGKLEGVMSFMEKKGPLTVTLAECEK IALRFLFALFPNADQYFRIRYDEKDEEENAVAGFTFEAHCHGVPLRFGQIRICVSRQT GYITVYMGPDIDPNKLATIDPVPAISVEQAKSIFWQHFKVELGWEREYGDDEEHSYRL VYKPVYPHFIDAHTGEPVFSIW*" /label="ycdB CDS" gene 282397..283815 /gene="ycdB" /locus_tag="BSU_02790" /old_locus_tag="BSU02790" /label="ycdB gene" promotor_-10 complement(283858..283876) /Source="Nicolas_upshift_promotors" /id="U202" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.685314685314685" /psig="0.96903096903097" /xcortree=2432 /SigmaFactorBS="agtgaagaaaggtccttttctattattgtCATTGTTTtttga gattctttCTGTTACTTTCATCACATActctcttctatatctgaggcaattgcgtgac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(283866) /Source="Nicolas_upshifts" /id="U202" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.685314685314685" /psig="0.96903096903097" /xcortree=2432 /SigmaFactorBS="agtgaagaaaggtccttttctattattgtCATTGTTTtttga gattctttCTGTTACTTTCATCACATActctcttctatatctgaggcaattgcgtgac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(283890..283897) /Source="Nicolas_upshift_promotors" /id="U202" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.685314685314685" /psig="0.96903096903097" /xcortree=2432 /SigmaFactorBS="agtgaagaaaggtccttttctattattgtCATTGTTTtttga gattctttCTGTTACTTTCATCACATActctcttctatatctgaggcaattgcgtgac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 283922..284001 /Source="Nicolas_S_feature" /locus_tag="new_302355_302434" /HighExp="ferm, M40t45, M0t45, Lbstat, S0, nit, LBGtran, Lbtran, G135, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.868" /TUlongSig="NA" /TUlongPSig="NA" /label="S102" upshifts 283922 /Source="Nicolas_upshifts" /id="U203" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.48051948051948" /psig="0.868131868131868" /xcortree=1586 /SigmaFactorBS="tgatgaaagtaacagaaagaatctcaaaaaacaatgacaata atagaaaaggacctttcttcACTTTAAatgaagaaaggtctTTTTATATAATAAACAG G" /listShort="S102, ycdC, S103" /listLong="rapJ" /label="upshifts" promotor_-35 283924..283930 /Source="Nicolas_upshift_promotors" /id="U203" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.48051948051948" /psig="0.868131868131868" /xcortree=1586 /SigmaFactorBS="tgatgaaagtaacagaaagaatctcaaaaaacaatgacaata atagaaaaggacctttcttcACTTTAAatgaagaaaggtctTTTTATATAATAAACAG G" /listShort="S102, ycdC, S103" /listLong="rapJ" /label="promotor_-35" promotor_-10 283945..283962 /Source="Nicolas_upshift_promotors" /id="U203" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.48051948051948" /psig="0.868131868131868" /xcortree=1586 /SigmaFactorBS="tgatgaaagtaacagaaagaatctcaaaaaacaatgacaata atagaaaaggacctttcttcACTTTAAatgaagaaaggtctTTTTATATAATAAACAG G" /listShort="S102, ycdC, S103" /listLong="rapJ" /label="promotor_-10" CDS 284002..285363 /gene="ycdC" /locus_tag="BSU_02800" /old_locus_tag="BSU02800" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388162.1" /db_xref="EnsemblGenomes-Gn:BSU02800" /db_xref="EnsemblGenomes-Tr:CAB12074" /db_xref="InterPro:IPR032599" /db_xref="SubtiList:BG12759" /db_xref="UniProtKB/Swiss-Prot:O34772" /translation="MVNKQLKKKAQEIGNVPTHYELEIEDYDQKQKKYGQAYFIWKDP KDPEKHITVELRNDGALLTFSTTVHSETDKKLPDAELKLTALQFAAANHPGTFMNFHF QGKEERGQHIRFVYTKMELGLPIPNSGFLIDMTRSGQIVHFLYYGEGHKAEVPTEFVA KEKVVSHYLNTMSFELMYDVIDGEQEPRLVYEPILPGYSYPADVDEIVPDQHIADERI ENTAPLPPLQNKEEVDIFALLGFTSDMQKVSERDFGEQIGSTWRRGAAPERKDLSIGS YFETRNKNTIKMKTDKRTGKLKAALSFMDWRNNLQCSTEECQEIALQFLYALYPRAAE FFRVNPVRIDERGRVRNHFSVWYKGVPLRFGAARIIVNPETGLIDAFMAPDIEPEQLE AINHRPDVSAEEAKEAFLAAFDVKLEWQPDFTAGSDQHCKLVYKPVYPSYIDAHIRKK KRL*" /label="ycdC CDS" gene 284002..285363 /gene="ycdC" /locus_tag="BSU_02800" /old_locus_tag="BSU02800" /label="ycdC gene" S_feature 285364..285944 /Source="Nicolas_S_feature" /locus_tag="new_303797_304377" /HighExp="ferm, M0t45, G135, G180, H2O2, M40t45, G150, Paraq, S0, nit" /AntisenseName="cwlK" /AntisenseCor="0.27553388443794402" /AntisenseRegPval="-5.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.868" /TUlongSig="NA" /TUlongPSig="NA" /label="S103" CDS complement(285371..285874) /gene="cwlK" /locus_tag="BSU_02810" /old_locus_tag="BSU02810" /EC_number="3.4.-.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17588176" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17588176; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="murein L,D:-endopeptidase" /protein_id="NP_388163.1" /db_xref="EnsemblGenomes-Gn:BSU02810" /db_xref="EnsemblGenomes-Tr:CAB12075" /db_xref="GOA:O34360" /db_xref="InterPro:IPR009045" /db_xref="SubtiList:BG12760" /db_xref="UniProtKB/Swiss-Prot:O34360" /translation="MNLPAKTFVILCILFLLDLCFSYIRHEWHSQNALQDMPVPSDLH PIVKQNADALKAAAANKGIDVVITEGFRSFKEQDELYKQGRTKKGNIVTYARGGESYH NYGLAIDFALQKKDGSIIWDMEYDGNQNGKSDWLEVVEIAKTLGFEWGGDWKRFKDYP HLEMIPN*" /label="cwlK CDS" gene complement(285371..285874) /gene="cwlK" /locus_tag="BSU_02810" /old_locus_tag="BSU02810" /label="cwlK gene" S_feature complement(285875..285956) /Source="Nicolas_S_feature" /locus_tag="new_304308_304389_c" /HighExp="Cold, T0.30H, LBGstat, C30, T-0.40H, T1.0H, T1.30H, H2O2, T0.0H, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.946" /TUlongSig="NA" /TUlongPSig="NA" /label="S104" upshifts 285946 /Source="Nicolas_upshifts" /id="U204" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2275 /SigmaFactorBS="tttctcaagatgtgctgaatgttaacgcttttaagtgattga ctctctctaaaagcgaacagcTATGATAAAATATAACATAAatagtagcaggaggaag g" /listShort="rapJ" /listLong="ycdF, ycdG, adcA, adcC, adcB" /label="upshifts" promotor_-10 complement(285948..285967) /Source="Nicolas_upshift_promotors" /id="U205" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.576423576423576" /psig="0.946053946053946" /xcortree=2433 /SigmaFactorBS="tgatggaatctttgctctcatcggtctgcctccttccTcctg ctactattTATGTTATATTTTATCATAGctgttcgcttttagagagagtcaatcactt a" /listShort="S104, cwlK" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature 285949..285968 /Source="Nicolas_upshift_promotors" /id="U204" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2275 /SigmaFactorBS="tttctcaagatgtgctgaatgttaacgcttttaagtgattga ctctctctaaaagcgaacagcTATGATAAAATATAACATAAatagtagcaggaggaag g" /listShort="rapJ" /listLong="ycdF, ycdG, adcA, adcC, adcB" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(285957) /Source="Nicolas_upshifts" /id="U205" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.576423576423576" /psig="0.946053946053946" /xcortree=2433 /SigmaFactorBS="tgatggaatctttgctctcatcggtctgcctccttccTcctg ctactattTATGTTATATTTTATCATAGctgttcgcttttagagagagtcaatcactt a" /listShort="S104, cwlK" /GFF_Attribute="listLong" /label="upshifts" CDS 285997..287118 /gene="rapJ" /locus_tag="BSU_02820" /old_locus_tag="BSU02820" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16816200" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16816200; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="response regulator aspartate phosphatase" /protein_id="NP_388164.1" /db_xref="EnsemblGenomes-Gn:BSU02820" /db_xref="EnsemblGenomes-Tr:CAB12076" /db_xref="GOA:O34327" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="PDB:4GYO" /db_xref="SubtiList:BG12663" /db_xref="UniProtKB/Swiss-Prot:O34327" /translation="MRAKIPSEEVAVKLNEWYKLIRAFEADQAEALKQEIEYDLEDME ENQDLLLYFSLMEFRHRIMLDKLMPVKDSDTKPPFSDMLNEIESNQQKLTGLLEYYFY YFRGMYEFKQKNFILAIDHYKHAEEKLEYVEDEIEKAEFLFKVAEVYYHIKQTYFSMN YASQALDIYTKYELYGRRRVQCEFIIAGNLTDVYHHEKALTHLCSALEHARQLEEAYM IAAAYYNVGHCKYSLGDYKEAEGYFKTAAAIFEEHNFQQAVQAVFSLTHIYCKEGKYD KAVEAYDRGIKSAAEWEDDMYLTKFRLIHELYLGSGDLNVLTECFDLLESRQLLADAE DLLHDTAERFNQLEHYESAAFFYRRLMNIKKKLAEQRFQ*" /label="rapJ CDS" gene 285997..287118 /gene="rapJ" /locus_tag="BSU_02820" /old_locus_tag="BSU02820" /label="rapJ gene" downshifts 287112 /Source="Nicolas_upshifts" /id="D115" /incds=0 /nref=88 /ntot=228 /MaxReadThrough="3.8438" /MaxDrop="5.06867" /score="32.2653577" /energy="-13.2" /TU="U204" /idTUdmin="U204" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" promotor_-35 287159..287165 /Source="Nicolas_upshift_promotors" /id="U206" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=187 /SigmaFactorBS="tggcagagaactacaggttctctgctttttttgtgcTGTTTT CaactcggaaaaacaGGGTATTTTCCACTGCATAgtgagaaacagaggaggatatcaa g" /listShort="ycdF, ycdG, adcA, adcC, adcB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 287180..287198 /Source="Nicolas_upshift_promotors" /id="U206" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=187 /SigmaFactorBS="tggcagagaactacaggttctctgctttttttgtgcTGTTTT CaactcggaaaaacaGGGTATTTTCCACTGCATAgtgagaaacagaggaggatatcaa g" /listShort="ycdF, ycdG, adcA, adcC, adcB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 287183 /Source="Nicolas_upshifts" /id="U206" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=187 /SigmaFactorBS="tggcagagaactacaggttctctgctttttttgtgcTGTTTT CaactcggaaaaacaGGGTATTTTCCACTGCATAgtgagaaacagaggaggatatcaa g" /listShort="ycdF, ycdG, adcA, adcC, adcB" /GFF_Attribute="listLong" /label="upshifts" CDS 287225..288001 /gene="ycdF" /locus_tag="BSU_02830" /old_locus_tag="BSU02830" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10220166, 11948145, 15805528; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388165.1" /db_xref="EnsemblGenomes-Gn:BSU02830" /db_xref="EnsemblGenomes-Tr:CAB12077" /db_xref="GOA:P80869" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12761" /db_xref="UniProtKB/Swiss-Prot:P80869" /translation="MYKDLTGKTAIVTGSSKGIGKAIAERFGKEKMNVVVNYHSDPSG ADETLEIIKQNGGKAVSVEADVSKEEGIQALLDTALEHFGTLDVMVNNSGFNGVEAMP HEMSLEDWQRVIDVNVTGTFLGAKAALNHMMKNNIKGNVLNISSVHQQIPRPVNVQYS TSKGGIKMMTETLALNYADKGIRVNAIAPGTIATESNVDTKKEESRQKQLKKIPMKAF GKPEEVAAAAAWLVSEEASYVTGATLFVDGGMTLYPSQLE*" /label="ycdF CDS" gene 287225..288001 /gene="ycdF" /locus_tag="BSU_02830" /old_locus_tag="BSU02830" /label="ycdF gene" downshifts complement(287232) /Source="Nicolas_upshifts" /id="D116" /incds=0 /nref=10 /ntot=23 /MaxReadThrough="0.31912" /MaxDrop="4.8095" /score="0.506500496" /energy="-5.8" /TU="NA" /idTUdmin="U205" /TUdmin="-1914" /isTUend="FALSE" /label="downshifts" CDS 288026..289711 /gene="ycdG" /locus_tag="BSU_02840" /old_locus_tag="BSU02840" /EC_number="3.2.1.10" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11544224; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oligo-carbohydrate hydrolase" /protein_id="NP_388166.1" /db_xref="EnsemblGenomes-Gn:BSU02840" /db_xref="EnsemblGenomes-Tr:CAB12078" /db_xref="GOA:O34364" /db_xref="InterPro:IPR006047" /db_xref="InterPro:IPR017853" /db_xref="SubtiList:BG12762" /db_xref="UniProtKB/Swiss-Prot:O34364" /translation="MKTDWWKDAVVYQIYPRSFQDSNGDGIGDLRGIISRLDYIKELG ADVIWICPIYPSPNVDYGYDVTNHKAIMDSYGTMDDFHELLDQVHQRGLKLVMDFVLN HTSVEHPWFKEAELDKNSKYRSYYYWRPGTKNGPPTDWLSNYGCPVWQYEEHTGEYYL HMNAVKQADLNWENPEVRQAVYDMMKFWLDKGVDGLRIDQLHLISKKEYLPSYEDYIN QQAEPKPFQPNGERIHDYLKEITDEVFSHYDVMSVGEVGSVTPEEGLKYTGTDKHELN MIFHFQHMELDQQPGKEHWDLKPLELSDLKSVLTKWQKKLEHQGWNTLFWCNHDQPRI VSRFGDDGEYRKASAKMLAAVIYFMKGTPYIYQGEEIGMTNAPFTRIEDYKDIQTINM YHKRVFEKGYDPNDVMRSILAKSRDHARTPMQWNSGKNAGFTDGTPWLKVNPNFTAIN VEEAQGDPDSVLNYYKKLISLRKQYADLMKGSFDLLLPDDPQLFVYMRENSKQQLLSV NNFSKEQAVFQWPKNCGKAQASLLLSNYNNDDLDDEMVFRPYESRVYLLDKTN*" /label="ycdG CDS" gene 288026..289711 /gene="ycdG" /locus_tag="BSU_02840" /old_locus_tag="BSU02840" /label="ycdG gene" promotor_no_box 288966..289066 /Source="Nicolas_upshift_promotors" /id="U207" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.487512487512487" /psig="0.044955044955045" /xcortree=117 /SigmaFactorBS="agaagcttgaacatcaaggctggaatacattgttttggtgca accacgaccagccccggattgtgtccagattcggagacgatggggaataccgcaaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 289026 /Source="Nicolas_upshifts" /id="U207" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.487512487512487" /psig="0.044955044955045" /xcortree=117 /SigmaFactorBS="agaagcttgaacatcaaggctggaatacattgttttggtgca accacgaccagccccggattgtgtccagattcggagacgatggggaataccgcaaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 289092 /Source="Nicolas_upshifts" /id="D117" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="7.77365" /MaxDrop="2.18547" /score="23.9074448" /energy="-10.2" /TU="U206" /idTUdmin="U204" /TUdmin=1914 /isTUend="FALSE" /label="downshifts" downshifts 289708 /Source="Nicolas_upshifts" /id="D118" /incds=0 /nref=13 /ntot=56 /MaxReadThrough="5.8252" /MaxDrop="5.18702" /score="23.9074448" /energy="-10.2" /TU="U206" /idTUdmin="U204" /TUdmin=2530 /isTUend="FALSE" /label="downshifts" promotor_-35 289802..289809 /Source="Nicolas_upshift_promotors" /id="U208" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.401598401598402" /psig="0.999000999001" /xcortree=669 /SigmaFactorBS="ggcgggaagaataaatgaaaatgaaatttatTCTTGCAAaac gtaatgacttcgGTTTATTATGATATAGGATTacaaaatcgttatcattttgatttaa a" /listShort="adcA, adcC, adcB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 289825..289844 /Source="Nicolas_upshift_promotors" /id="U208" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.401598401598402" /psig="0.999000999001" /xcortree=669 /SigmaFactorBS="ggcgggaagaataaatgaaaatgaaatttatTCTTGCAAaac gtaatgacttcgGTTTATTATGATATAGGATTacaaaatcgttatcattttgatttaa a" /listShort="adcA, adcC, adcB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 289831 /Source="Nicolas_upshifts" /id="U208" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.401598401598402" /psig="0.999000999001" /xcortree=669 /SigmaFactorBS="ggcgggaagaataaatgaaaatgaaatttatTCTTGCAAaac gtaatgacttcgGTTTATTATGATATAGGATTacaaaatcgttatcattttgatttaa a" /listShort="adcA, adcC, adcB" /GFF_Attribute="listLong" /label="upshifts" CDS 289899..290858 /gene="znuA" /locus_tag="BSU_02850" /old_locus_tag="BSU02850" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9379902, 12426338, 14730579, 21813502; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="Zn(II)-binding lipoprotein" /protein_id="NP_388167.1" /db_xref="EnsemblGenomes-Gn:BSU02850" /db_xref="EnsemblGenomes-Tr:CAB12079" /db_xref="GOA:O34966" /db_xref="InterPro:IPR006127" /db_xref="InterPro:IPR006128" /db_xref="InterPro:IPR006129" /db_xref="PDB:2O1E" /db_xref="SubtiList:BG12763" /db_xref="UniProtKB/Swiss-Prot:O34966" /translation="MFKKWSGLFVIAACFLLVAACGNSSTKGSADSKGDKLHVVTTFY PMYEFTKQIVKDKGDVDLLIPSSVEPHDWEPTPKDIANIQDADLFVYNSEYMETWVPS AEKSMGQGHAVFVNASKGIDLMEGSEEEHEEHDHGEHEHSHAMDPHVWLSPVLAQKEV KNITAQIVKQDPDNKEYYEKNSKEYIAKLQDLDKLYRTTAKKAEKKEFITQHTAFGYL AKEYGLKQVPIAGLSPDQEPSAASLAKLKTYAKEHNVKVIYFEEIASSKVADTLASEI GAKTEVLNTLEGLSKEEQDKGLGYIDIMKQNLDALKDSLLVKS*" /label="znuA CDS" gene 289899..290858 /gene="znuA" /locus_tag="BSU_02850" /old_locus_tag="BSU02850" /label="znuA gene" promotor_-35 290454..290460 /Source="Nicolas_upshift_promotors" /id="U209" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.461538461538462" /psig="0.998001998001998" /xcortree=670 /SigmaFactorBS="aacaaagaatactatgagaaaaatagtaaagaatatATTGCA AaactgcaggatctTGATAAACTATATCGTACAAccgcaaaaaaagcggagaaaaaag a" /listShort="adcC, adcB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 290474..290493 /Source="Nicolas_upshift_promotors" /id="U209" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.461538461538462" /psig="0.998001998001998" /xcortree=670 /SigmaFactorBS="aacaaagaatactatgagaaaaatagtaaagaatatATTGCA AaactgcaggatctTGATAAACTATATCGTACAAccgcaaaaaaagcggagaaaaaag a" /listShort="adcC, adcB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 290478 /Source="Nicolas_upshifts" /id="U209" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.461538461538462" /psig="0.998001998001998" /xcortree=670 /SigmaFactorBS="aacaaagaatactatgagaaaaatagtaaagaatatATTGCA AaactgcaggatctTGATAAACTATATCGTACAAccgcaaaaaaagcggagaaaaaag a" /listShort="adcC, adcB" /GFF_Attribute="listLong" /label="upshifts" downshifts 290830 /Source="Nicolas_upshifts" /id="D119" /incds=0 /nref=140 /ntot=250 /MaxReadThrough="6.07181" /MaxDrop="5.15011" /score="8.99106569" /energy="-15.9" /TU="U206,U208,U209" /idTUdmin="U206" /TUdmin="-1562" /isTUend="FALSE" /label="downshifts" CDS 290914..291609 /gene="znuC" /locus_tag="BSU_02860" /old_locus_tag="BSU02860" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9379902, 9811636, 21813502" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9379902, 9811636, 21813502; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Zn(II) transporter (ATP-binding protein)" /protein_id="NP_388168.1" /db_xref="EnsemblGenomes-Gn:BSU02860" /db_xref="EnsemblGenomes-Tr:CAB12080" /db_xref="GOA:O34946" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12764" /db_xref="UniProtKB/Swiss-Prot:O34946" /translation="MNLVSLKDIVFGYSHTPVLDKVSLDIESGEFVGITGPNGASKST LIKVMLGMLKPWEGTVTISKRNTEGKRLTIGYVPQQISSFNAGFPSTVLELVQSGRYT KGKWFKRLNEEDHLEVEKALKMVEMWDLRHRKIGDLSGGQKQKICIARMLASNPDLLM LDEPTTAVDYDSRKGFYEFMHHLVKNHNRTVVMVTHEQNEVQQFLDKVIRLERGEKGG WKCLTWNSCDELF*" /label="znuC CDS" gene 290914..291609 /gene="znuC" /locus_tag="BSU_02860" /old_locus_tag="BSU02860" /label="znuC gene" CDS 291567..292409 /gene="znuB" /locus_tag="BSU_02870" /old_locus_tag="BSU02870" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 9379902, 9811636, 21813502" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 9379902, 9811636, 21813502; Product type t: transporter" /codon_start=1 /transl_table=11 /product="high affinity Zn(II) ABC transporter (permease)" /protein_id="NP_388169.1" /db_xref="EnsemblGenomes-Gn:BSU02870" /db_xref="EnsemblGenomes-Tr:CAB12081" /db_xref="GOA:O34610" /db_xref="InterPro:IPR001626" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG12765" /db_xref="UniProtKB/Swiss-Prot:O34610" /translation="MEMFDLEFMRRAFLAGGMIAVMAPILGVYLVLRRQALMADTLSH ISLSGVAIGFFLSTNITAASIVVVTIGAIGIEYMRRAYRTYSEVSIAILMAAGLSFAM FLISLSKGTANMSIDQYLFGSLVTVNQQQVYIISIITLLILLYFIVLRRPLYLLTFDE ATAKTSGINTNVLSLSFSIVTGLAISVIIPIIGVLLVSALLVLPAAFAIRIAKGFNMV FITAILISLFSVFTGLTSSYQLGTPPGPSITLLLIVLLLIGFAVQGVWTFIKKEAQRK KRSR*" /label="znuB CDS" gene 291567..292409 /gene="znuB" /locus_tag="BSU_02870" /old_locus_tag="BSU02870" /label="znuB gene" downshifts 292396 /Source="Nicolas_upshifts" /id="D120" /incds=0 /nref=168 /ntot=266 /MaxReadThrough="2.4865" /MaxDrop="6.44929" /score="27.8218406" /energy="-13.6" /TU="NA" /idTUdmin="U206" /TUdmin=4 /isTUend="TRUE" /label="downshifts" CDS complement(292447..293442) /gene="yceB" /locus_tag="BSU_02880" /old_locus_tag="BSU02880" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16428414; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative luciferase-like monooxygenase" /protein_id="NP_388170.2" /db_xref="EnsemblGenomes-Gn:BSU02880" /db_xref="EnsemblGenomes-Tr:CAB12082" /db_xref="GOA:O34504" /db_xref="InterPro:IPR011251" /db_xref="InterPro:IPR019949" /db_xref="InterPro:IPR036661" /db_xref="SubtiList:BG12766" /db_xref="UniProtKB/Swiss-Prot:O34504" /translation="MIHLSILDQAPVSKGESPVTTLQHSVELAQLSEQWGYKRYWFAE HHSTKGLASTAPEIMIARIAAQTNTIRVGSGGVLLPQYSPFKVAETFRQLEALYPNRI DLGVGRSPGGTTKTRLALTDGVKKSLTEFNRQLQDVSYFLTDSLPPDHPYAGIKAAPL IGTAPELWVLGLGENSARRAAHQGIGYVFGHFINPERGENAFRIYRESFRPSAHFSNP SALFTIFVICAKTDEEAEELALSQDLWLLRVGKGLDSRVPSIEEAKAHPYTASDKKLI EENRKRMVIGSPTTVKQQLLDLTGCYETNEIMVLCNVFDFEAKKESYERLAELFL*" /label="yceB CDS" gene complement(292447..293442) /gene="yceB" /locus_tag="BSU_02880" /old_locus_tag="BSU02880" /label="yceB gene" promotor_-35 293398..293405 /Source="Nicolas_upshift_promotors" /id="U210" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig="0.997002997002997" /xcortree=1949 /SigmaFactorBS="accgaatgctggagagttgtcacagggctttcTCCTTTAGaa acaggtgcctgaTCAAGTATGCTTAAATGAATcaaaaggccgcttcctttctgtctgt t" /listShort="S105" /listLong="S106, yceC, yceD, yceE, yceF, yceG, yceH" /label="promotor_-35" promotor_-10 293420..293439 /Source="Nicolas_upshift_promotors" /id="U210" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig="0.997002997002997" /xcortree=1949 /SigmaFactorBS="accgaatgctggagagttgtcacagggctttcTCCTTTAGaa acaggtgcctgaTCAAGTATGCTTAAATGAATcaaaaggccgcttcctttctgtctgt t" /listShort="S105" /listLong="S106, yceC, yceD, yceE, yceF, yceG, yceH" /label="promotor_-10" S_feature 293426..293628 /Source="Nicolas_S_feature" /locus_tag="new_311859_312061" /HighExp="Diami, Etha, dia5, Salt, H2O2, dia15, Paraq, T-0.40H, T0.30H, G135" /AntisenseName="yceB" /AntisenseCor="0.84300534435872998" /AntisenseRegPval="-73.099999999999994" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S105" upshifts 293426 /Source="Nicolas_upshifts" /id="U210" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig="0.997002997002997" /xcortree=1949 /SigmaFactorBS="accgaatgctggagagttgtcacagggctttcTCCTTTAGaa acaggtgcctgaTCAAGTATGCTTAAATGAATcaaaaggccgcttcctttctgtctgt t" /listShort="S105" /listLong="S106, yceC, yceD, yceE, yceF, yceG, yceH" /label="upshifts" promotor_-10 complement(293474..293493) /Source="Nicolas_upshift_promotors" /id="U211" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig="0.992007992007992" /xcortree=1952 /SigmaFactorBS="gctataaagtgcgcttcttaaacaaacCATTTGACgcgggca agtcattTTGCCTATTCTGGTGTCACCatctaaaaacagacagaaaggaagcggcctt t" /listShort="yceB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(293482) /Source="Nicolas_upshifts" /id="U211" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig="0.992007992007992" /xcortree=1952 /SigmaFactorBS="gctataaagtgcgcttcttaaacaaacCATTTGACgcgggca agtcattTTGCCTATTCTGGTGTCACCatctaaaaacagacagaaaggaagcggcctt t" /listShort="yceB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(293508..293515) /Source="Nicolas_upshift_promotors" /id="U211" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig="0.992007992007992" /xcortree=1952 /SigmaFactorBS="gctataaagtgcgcttcttaaacaaacCATTTGACgcgggca agtcattTTGCCTATTCTGGTGTCACCatctaaaaacagacagaaaggaagcggcctt t" /listShort="yceB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 293612..293621 /Source="Nicolas_upshift_promotors" /id="U212" /multdbtbs="SigA,SigW" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1676 /SigmaFactorBS="agttttttttcgaggtttttcgtcaattattcttaactttta CGAAACTTTGatataataacaaACGTATATATTAGTAAtttacggcttattttccttg t" /listShort="S106, yceC, yceD, yceE, yceF, yceG, yceH, yceI" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 293630..293725 /Source="Nicolas_S_feature" /locus_tag="new_312063_312158" /HighExp="T0.0H, T-0.40H, T-1.10H, T0.30H, Salt, T1.0H, Etha, T-1.40H, T1.30H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.999" /TUlongSig="SigA" /TUlongPSig="0.997" /label="S106" upshifts 293630 /Source="Nicolas_upshifts" /id="U212" /multdbtbs="SigA,SigW" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1676 /SigmaFactorBS="agttttttttcgaggtttttcgtcaattattcttaactttta CGAAACTTTGatataataacaaACGTATATATTAGTAAtttacggcttattttccttg t" /listShort="S106, yceC, yceD, yceE, yceF, yceG, yceH, yceI" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 293634..293649 /Source="Nicolas_upshift_promotors" /id="U212" /multdbtbs="SigA,SigW" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1676 /SigmaFactorBS="agttttttttcgaggtttttcgtcaattattcttaactttta CGAAACTTTGatataataacaaACGTATATATTAGTAAtttacggcttattttccttg t" /listShort="S106, yceC, yceD, yceE, yceF, yceG, yceH, yceI" /GFF_Attribute="listLong" /label="promotor_-10" CDS 293726..294325 /gene="yceC" /locus_tag="BSU_02890" /old_locus_tag="BSU02890" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 24366250; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative stress adaptation protein (tellurite resistance)" /protein_id="NP_388171.1" /db_xref="EnsemblGenomes-Gn:BSU02890" /db_xref="EnsemblGenomes-Tr:CAB12083" /db_xref="GOA:P81100" /db_xref="InterPro:IPR003325" /db_xref="SubtiList:BG12767" /db_xref="UniProtKB/Swiss-Prot:P81100" /translation="MAISLEKGQRIDLTKGKAGLSKLMVGLGWDPVSSGGGFFSKLLG GGGPNIDCDASVLMLENGKFTDKKNLIYFGNLKSRCGGVQHTGDNLTGDGAGDDEQIM IDLDKVPGNIDKLVFVVNIYDCVRRKQDFGMIQNAFIRVVDQSNHEEMLKYNLRDNYA GRTSLITAEIYRSGSEWKFAAVGEGTNDTRLEDIISRYV*" /label="yceC CDS" gene 293726..294325 /gene="yceC" /locus_tag="BSU_02890" /old_locus_tag="BSU02890" /label="yceC gene" CDS 294347..294928 /gene="yceD" /locus_tag="BSU_02900" /old_locus_tag="BSU02900" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735, 24366250; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative stress adaptation protein (tellurite resistance)" /protein_id="NP_388172.1" /db_xref="EnsemblGenomes-Gn:BSU02900" /db_xref="EnsemblGenomes-Tr:CAB12084" /db_xref="GOA:P80875" /db_xref="InterPro:IPR003325" /db_xref="SubtiList:BG12768" /db_xref="UniProtKB/Swiss-Prot:P80875" /translation="MTISLAKGQKVDLTKTNPGLSKVVVGLGWDTNKYDGGHDFDLDS SVFLLDAAGKCASPNDFIFYNQLEGGNGSVVHSGDNLTGAGEGDDENVKVNLSAVPAN IDKISFVITIHDAEARSQNFGQVSNAFVRIVNEETNEELIRYDLAEDFSIETAIIAGE LYRHNGEWKFSAIGSGYQGGLARIATDYGLQVG*" /label="yceD CDS" gene 294347..294928 /gene="yceD" /locus_tag="BSU_02900" /old_locus_tag="BSU02900" /label="yceD gene" CDS 294963..295541 /gene="yceE" /locus_tag="BSU_02910" /old_locus_tag="BSU02910" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735, 24366250, 25355936; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative stress adaptation protein (tellurite resistance)" /protein_id="NP_388173.1" /db_xref="EnsemblGenomes-Gn:BSU02910" /db_xref="EnsemblGenomes-Tr:CAB12085" /db_xref="GOA:O34384" /db_xref="InterPro:IPR003325" /db_xref="SubtiList:BG12769" /db_xref="UniProtKB/Swiss-Prot:O34384" /translation="MAIQLSKGQRIDLTKTNPGLTKAVIGLGWDTNKYSGGHDFDLDA SAFLVDAHDNCVNDLDFVFYNNLEHPSGGVIHTGDNRTGEGDGDDEQIIVDFSKIPAH IEKIGITVTIHDAEARSQNFGQVSNAFVRVVDEETQNELLRFDLGEDFSIETAVVVCE LYRHGGEWKFNAIGSGFSGGLAALCRNYGLQV*" /label="yceE CDS" gene 294963..295541 /gene="yceE" /locus_tag="BSU_02910" /old_locus_tag="BSU02910" /label="yceE gene" CDS 295592..296365 /gene="yceF" /locus_tag="BSU_02920" /old_locus_tag="BSU02920" /function="16.8: Protect" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735, 24366250; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative stress adaptation transporter (tellurite resistance)" /protein_id="NP_388174.1" /db_xref="EnsemblGenomes-Gn:BSU02920" /db_xref="EnsemblGenomes-Tr:CAB12086" /db_xref="GOA:O34447" /db_xref="InterPro:IPR005496" /db_xref="InterPro:IPR022493" /db_xref="SubtiList:BG12770" /db_xref="UniProtKB/Swiss-Prot:O34447" /translation="MDFLHHILSTYASFFDWKMWGEVLTDPVSWGLIGSLVVLEGLLS ADNALVLAVMVKHLPEKQRKKALTYGLFGAYIFRFIFIGLGMLLIKFWWIKVLGALYL AWLVIKHFWIGEKEEEADGMKKNSWMVRTFGIFWATVISVELMDLAFSVDSILAAFAV SEKVWVLLIGGMLGILMMRTVAKVFLVLIDKIPELENTAFVLIGIIALKMAGSAFHYE MPHSVFFIIIIAAFAVTLIIHYINKQKQVREQTAASKEE*" /label="yceF CDS" gene 295592..296365 /gene="yceF" /locus_tag="BSU_02920" /old_locus_tag="BSU02920" /label="yceF gene" downshifts 296352 /Source="Nicolas_upshifts" /id="D121" /incds=0 /nref=46 /ntot=239 /MaxReadThrough="6.82513" /MaxDrop="4.0674" /score="4.0495978" /energy="-8.2" /TU="U212" /idTUdmin="U210" /TUdmin=2728 /isTUend="FALSE" /label="downshifts" CDS 296450..298063 /gene="yceG" /locus_tag="BSU_02930" /old_locus_tag="BSU02930" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 24366250; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative toxic compound adaptation protein (tellurite resistance)" /protein_id="NP_388175.1" /db_xref="EnsemblGenomes-Gn:BSU02930" /db_xref="EnsemblGenomes-Tr:CAB12087" /db_xref="InterPro:IPR025647" /db_xref="SubtiList:BG12771" /db_xref="UniProtKB/Swiss-Prot:O34809" /translation="MRQEELTIHKALPADGDWKSLLFQPLPERDHYETAQGLSFSRLA GQILGTPIDETDYYNELYELSVNDRITILSETLDKTIEPETFQKLQHIHSINQKEKGL SVSRFVAFLDGEKLIAKHSNPLMHRHLRKALMTLLHTFADSHEKGLNHPDFRRVLLDV SKFSLNHLNPWLEKTDIEREMPKVVWYGDATKSQLYFLYYLMLVGCDVLLFHPAGTDQ LALVDPKQELGFTEKLPDVSELQPFPKEKPDRKSTVAYRSTKEIEHVLNHEESMLYKP WQFRDHTPVSVTLKTTYDELFLITKERAFIRPNFKADKHSIEIPNVFAKIMGVSKDNK EYWNRLHTLADYQETEMVRSFPFTEEIKSNYQFHYSHALDQEGNIDPDKLMASNVWQY KQLPAGVQTAIAKTISRMCRYPRLKALHQEQVKDVQIYLFKQTTNLPANLLKLIQMFD YAQTVPKLVLYHTEMSGGLTRSDAAALLFLNEIGIDIIIYNPPGHQDIEQFIEEDQYD IHWLDDMVFQQDYKEPSLVKRLFRTITQK*" /label="yceG CDS" gene 296450..298063 /gene="yceG" /locus_tag="BSU_02930" /old_locus_tag="BSU02930" /label="yceG gene" CDS 298079..299170 /gene="yceH" /locus_tag="BSU_02940" /old_locus_tag="BSU02940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735, 24366250; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative reactive oxygen species resistance protein" /protein_id="NP_388176.1" /db_xref="EnsemblGenomes-Gn:BSU02940" /db_xref="EnsemblGenomes-Tr:CAB12088" /db_xref="InterPro:IPR008863" /db_xref="SubtiList:BG12772" /db_xref="UniProtKB/Swiss-Prot:O34833" /translation="MTTENQNPLVLDKNEEISQQKADDIRLQLRQEPEVKRLAQQIDV KNQMELLEYGKEPAVEISKFSDRILGMMKTTSVTDSGTMLTQLGKIMDRFDKNDFDEP KGLMAKIFKRGGSMIEKIFKKYQTLGGEIEKIHVEISKYKDEMTKTNYTLDEMYENNI KYYMELEKYVVAGQMKLEEMQSILPSYEEKAASGNQLAQMQLDTLRNGIQALEERVYD LDMARMVALQTAPQIRLLQRGNAKLIGKINSAFIITIPIFKNGIIQAVTVKRQKLVAD SMSELDRRTNEMLKRNAENISSQSVEIARMAGRPSIDIETIESSWNTIVSGMQETKQI EEENKRLREDGARRIAQLQDNIKKAALQQ*" /label="yceH CDS" gene 298079..299170 /gene="yceH" /locus_tag="BSU_02940" /old_locus_tag="BSU02940" /label="yceH gene" downshifts 299144 /Source="Nicolas_upshifts" /id="D122" /incds=0 /nref=85 /ntot=228 /MaxReadThrough="4.46836" /MaxDrop="4.05585" /score="-6.59172775" /energy="-17.5" /TU="U212" /idTUdmin="U212" /TUdmin="-1322" /isTUend="FALSE" /label="downshifts" promotor_-35 299224..299231 /Source="Nicolas_upshift_promotors" /id="U213" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig="0.998001998001998" /xcortree=2427 /SigmaFactorBS="aagcggggtatttcaattacatcatttagtTAATGACAatgt gtaaagacagGTGTAAACTTAAACGGTAATcattttgcatatcagaggtgttggcaat g" /listShort="yceI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 299246..299265 /Source="Nicolas_upshift_promotors" /id="U213" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig="0.998001998001998" /xcortree=2427 /SigmaFactorBS="aagcggggtatttcaattacatcatttagtTAATGACAatgt gtaaagacagGTGTAAACTTAAACGGTAATcattttgcatatcagaggtgttggcaat g" /listShort="yceI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 299254 /Source="Nicolas_upshifts" /id="U213" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig="0.998001998001998" /xcortree=2427 /SigmaFactorBS="aagcggggtatttcaattacatcatttagtTAATGACAatgt gtaaagacagGTGTAAACTTAAACGGTAATcattttgcatatcagaggtgttggcaat g" /listShort="yceI" /GFF_Attribute="listLong" /label="upshifts" CDS 299292..300494 /gene="niaP" /locus_tag="BSU_02950" /old_locus_tag="BSU02950" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 18276644, 21953179" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 18276644, 21953179; Product type t: transporter" /codon_start=1 /transl_table=11 /product="niacin permease" /protein_id="NP_388177.1" /db_xref="EnsemblGenomes-Gn:BSU02950" /db_xref="EnsemblGenomes-Tr:CAB12089" /db_xref="GOA:O34691" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12773" /db_xref="UniProtKB/Swiss-Prot:O34691" /translation="MGKQQPISQRKLLGVAGLGWLFDAMDVGILSFIIAALHVEWNLS PEEMKWIGSVNSIGMAAGAFLFGLLADRIGRKKVFIITLLCFSIGSGISAFVTSLSAF LILRFVIGMGLGGELPVASTLVSEAVVPEKRGRVIVLLESFWAVGWLAAALISYFVIP SFGWQAALLLTALTAFYALYLRTSLPDSPKYESLSAKKRSMWENVKSVWARQYIRPTV MLSIVWFCVVFSYYGMFLWLPSVMLLKGFSMIQSFEYVLLMTLAQLPGYFSAAWLIEK AGRKWILVVYLIGTAGSAYFFGTADSLSLLLTAGVLLSFFNLGAWGVLYAYTPEQYPT AIRATGSGTTAAFGRIGGIFGPLLVGTLAARHISFSVIFSIFCIAILLAVACILIMGK ETKQTELE*" /label="niaP CDS" gene 299292..300494 /gene="niaP" /locus_tag="BSU_02950" /old_locus_tag="BSU02950" /label="niaP gene" downshifts 300474 /Source="Nicolas_upshifts" /id="D123" /incds=0 /nref=8 /ntot=184 /MaxReadThrough="4.1968" /MaxDrop="3.48367" /score="13.0427769" /energy="-10.6" /TU="U213" /idTUdmin="U212" /TUdmin=8 /isTUend="TRUE" /label="downshifts" CDS complement(300747..301919) /gene="yceJ" /locus_tag="BSU_02960" /old_locus_tag="BSU02960" /function="16.8: Protect" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative carbohydrate transporter (possibly exporter)" /protein_id="NP_388178.1" /db_xref="EnsemblGenomes-Gn:BSU02960" /db_xref="EnsemblGenomes-Tr:CAB12090" /db_xref="GOA:O34724" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12774" /db_xref="UniProtKB/Swiss-Prot:O34724" /translation="MNRIWLFFSVMFVIGTDTFLLSPLLPLLQDQFHVSTDLSGWMVS AYALGYALFAFIAGPISDRLNRKTVMLWGLAGFIVSTFLCGIAPSFAAMCLFRFAAGV SAAFVTPQIWASIPVIVQPSQIIKGMGIATAGLAASQMLGLPIGGFLASFTWHTPFFV LSACSLILLLILAAVMPGIRPSEPLARPSIVNPYRELFSLPKTSVILLAYFLFQTGNF ASFSFLGTWLSADYHLTVSQIGAAMLVLGLGNMLGSLIGSRVSEKLGMFKTLISGMLL MGALYFALPFFPNLFLVEAGFFLTFFTAGIIFPLMMGVFQSIAPNARGTIASLSNAAM YAGTTVGTSIAGFLYQSTQHFGAVTGFTAILFILSMTLYQTISKTGKRQSTARAQL*" /label="yceJ CDS" gene complement(300747..301919) /gene="yceJ" /locus_tag="BSU_02960" /old_locus_tag="BSU02960" /label="yceJ gene" downshifts complement(300762) /Source="Nicolas_upshifts" /id="D124" /incds=0 /nref=1 /ntot=7 /MaxReadThrough="2.6211" /MaxDrop="2.7452" /score="9.21991741" /energy="-12.6" /TU="NA" /idTUdmin="U214" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(301988..302290) /gene="yceK" /locus_tag="BSU_02970" /old_locus_tag="BSU02970" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (ArsR family)" /protein_id="NP_388179.1" /db_xref="EnsemblGenomes-Gn:BSU02970" /db_xref="EnsemblGenomes-Tr:CAB12091" /db_xref="GOA:O34464" /db_xref="InterPro:IPR001845" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12775" /db_xref="UniProtKB/Swiss-Prot:O34464" /translation="MYYSFMTMKQSDDQIRAQIFKALSDESRLAIIRTLYVSGKELSC GEVGEKCNIVKTTASYHFKTLREAGLTATRKDSRTKYVSLREDTFQTYLPGFLETL*" /label="yceK CDS" gene complement(301988..302290) /gene="yceK" /locus_tag="BSU_02970" /old_locus_tag="BSU02970" /label="yceK gene" downshifts complement(302016) /Source="Nicolas_upshifts" /id="D125" /incds=0 /nref=221 /ntot=261 /MaxReadThrough="5.67096" /MaxDrop="6.89889" /score="2.01231069" /energy="-4.8" /TU="U214" /idTUdmin="U214" /TUdmin="-1254" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(302273..302292) /Source="Nicolas_upshift_promotors" /id="U214" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.455544455544456" /psig="0.999000999001" /xcortree=635 /SigmaFactorBS="ccttcctcttatgacttcctgctcctttactggaaaaataAG TTGCTttttcaacacccaTTATGTATTATAGTTTCATGactatgaaacaatcagatga t" /listShort="yceK, yceJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(302292) /Source="Nicolas_upshifts" /id="U214" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.455544455544456" /psig="0.999000999001" /xcortree=635 /SigmaFactorBS="ccttcctcttatgacttcctgctcctttactggaaaaataAG TTGCTttttcaacacccaTTATGTATTATAGTTTCATGactatgaaacaatcagatga t" /listShort="yceK, yceJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(302306..302312) /Source="Nicolas_upshift_promotors" /id="U214" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.455544455544456" /psig="0.999000999001" /xcortree=635 /SigmaFactorBS="ccttcctcttatgacttcctgctcctttactggaaaaataAG TTGCTttttcaacacccaTTATGTATTATAGTTTCATGactatgaaacaatcagatga t" /listShort="yceK, yceJ" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 302539..302558 /Source="Nicolas_upshift_promotors" /id="U215" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.555444555444555" /psig="0.99100899100899" /xcortree=2422 /SigmaFactorBS="gtttataaagaaatggtacagaataaaagagaatatgctgtt tgtgtgggaagttacataAATGTTACGGTAATAAAGATtgcttaatatggagggaaaa t" /listShort="opuAA, opuAB, opuAC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 302539 /Source="Nicolas_upshifts" /id="U215" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.555444555444555" /psig="0.99100899100899" /xcortree=2422 /SigmaFactorBS="gtttataaagaaatggtacagaataaaagagaatatgctgtt tgtgtgggaagttacataAATGTTACGGTAATAAAGATtgcttaatatggagggaaaa t" /listShort="opuAA, opuAB, opuAC" /GFF_Attribute="listLong" /label="upshifts" CDS 302580..303836 /gene="opuAA" /locus_tag="BSU_02980" /old_locus_tag="BSU02980" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7622480, 16225868, 16645306, 25012968" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7622480, 16225868, 16645306, 25012968; Product type t: transporter" /codon_start=1 /transl_table=11 /product="L-proline betaine and betonicine ABC transporter(ATP-binding protein)" /protein_id="NP_388180.2" /db_xref="EnsemblGenomes-Gn:BSU02980" /db_xref="EnsemblGenomes-Tr:CAB12092" /db_xref="GOA:P46920" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR005892" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11370" /db_xref="UniProtKB/Swiss-Prot:P46920" /translation="MSVDEKPIKIKVEKVSKIFGKQTKKAVQMLANGKTKKEILKATG STVGVNQADFEVYDGEIFVIMGLSGSGKSTLVRMLNRLIEPTAGNIYIDGDMITNMSK DQLREVRRKKISMVFQKFALFPHRTILENTEYGLELQGVDKQERQQKALESLKLVGLE GFEHQYPDQLSGGMQQRVGLARALTNDPDILLMDEAFSALDPLIRKDMQDELLDLHDN VGKTIIFITHDLDEALRIGDRIVLMKDGNIVQIGTPEEILMNPSNEYVEKFVEDVDLS KVLTAGHIMKRAETVRIDKGPRVALTLMKNLGISSIYAVDKQKKLLGVIYASDAKKAA ESDLSLQDILNTEFTTVPENTYLTEIFDVVSDANIPIAVVDEKQRMKGIVVRGALIGA LAGNNEYINAEGTNEQTQDPSAQEVK*" /label="opuAA CDS" gene 302580..303836 /gene="opuAA" /locus_tag="BSU_02980" /old_locus_tag="BSU02980" /label="opuAA gene" downshifts complement(302588) /Source="Nicolas_upshifts" /id="D126" /incds=0 /nref=108 /ntot=175 /MaxReadThrough="2.83797" /MaxDrop="5.18503" /score="2.01231069" /energy="-4.8" /TU="NA" /idTUdmin="U214" /TUdmin="-1826" /isTUend="FALSE" /label="downshifts" CDS 303838..304686 /gene="opuAB" /locus_tag="BSU_02990" /old_locus_tag="BSU02990" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8752321, 15849754, 16225868, 16645306, 16850406, 25012968" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8752321, 15849754, 16225868, 16645306, 16850406, 25012968; Product type t : transporter" /codon_start=1 /transl_table=11 /product="L-proline betaine and betonicine ABC transporter(permease)" /protein_id="NP_388181.1" /db_xref="EnsemblGenomes-Gn:BSU02990" /db_xref="EnsemblGenomes-Tr:CAB12093" /db_xref="GOA:P46921" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11371" /db_xref="UniProtKB/Swiss-Prot:P46921" /translation="MDRLPRIPLADIIDRFVDWITMTFGGFFDGIANGLAAFVNGIVT GLGFIPSILLTIIFAALAWWISTRGIALFTLIGFLLIDYLGYWDPMLQTLALVLTSVI ISIVVGVPIGIWASQKETVRRIVTPILDLMQTMPAFVYLLPAIFFFNIGVVPGVVASV IFAMPPTIRMTVLGIKQVPADLIEATEAFGSTTAQRLFKVQLPLATKTILAGINQSIM LALSMVVIAAMVGAPGLGSEVYSAVTQLKTGVGVEAGIAIVIVAITLDRITQNIKVKK KSRGNA*" /label="opuAB CDS" gene 303838..304686 /gene="opuAB" /locus_tag="BSU_02990" /old_locus_tag="BSU02990" /label="opuAB gene" CDS 304686..305567 /gene="opuAC" /locus_tag="BSU_03000" /old_locus_tag="BSU03000" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7622480, 16225868, 16645306, 25012968" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7622480, 16225868, 16645306, 25012968; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="L-proline betaine and betonicine ABC transporterABC transporter (glycine betaine-binding lipoprotein)" /protein_id="NP_388182.1" /db_xref="EnsemblGenomes-Gn:BSU03000" /db_xref="EnsemblGenomes-Tr:CAB12094" /db_xref="GOA:P46922" /db_xref="InterPro:IPR007210" /db_xref="PDB:2B4L" /db_xref="PDB:2B4M" /db_xref="PDB:3CHG" /db_xref="SubtiList:BG11372" /db_xref="UniProtKB/Swiss-Prot:P46922" /translation="MLKKIIGIGVSAMLALSLAACGSENDENASAAEQVNKTIIGIDP GSGIMSLTDKAMKDYDLNDWTLISASSAAMTATLKKSYDRKKPIIITGWTPHWMFSRY KLKYLDDPKQSYGSAEEIHTITRKGFSKEQPNAAKLLSQFKWTQDEMGEIMIKVEEGE KPAKVAAEYVNKHKDQIAEWTKGVQKVKGDKINLAYVAWDSEIASTNVIGKVLEDLGY EVTLTQVEAGPMWTAIATGSADASLSAWLPNTHKAYAAKYKGKYDDIGTSMTGVKMGL VVPQYMKNVNSIEDLKK*" /label="opuAC CDS" gene 304686..305567 /gene="opuAC" /locus_tag="BSU_03000" /old_locus_tag="BSU03000" /label="opuAC gene" downshifts 305548 /Source="Nicolas_upshifts" /id="D127" /incds=0 /nref=254 /ntot=269 /MaxReadThrough="0.74967" /MaxDrop="8.21394" /score="33.6263027" /energy="-12.2" /TU="NA" /idTUdmin="U215" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(305580) /Source="Nicolas_upshifts" /id="D128" /incds=0 /nref=2 /ntot=62 /MaxReadThrough="4.29566" /MaxDrop="3.9514" /score="29.8489328" /energy="-12.2" /TU="U216" /idTUdmin="U216" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" CDS complement(305605..306756) /gene="amhX" /locus_tag="BSU_03010" /old_locus_tag="BSU03010" /EC_number="3.5.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8768514; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative amidohydrolase" /protein_id="NP_388183.2" /db_xref="EnsemblGenomes-Gn:BSU03010" /db_xref="EnsemblGenomes-Tr:CAB12095" /db_xref="GOA:P54983" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR017439" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG11789" /db_xref="UniProtKB/Swiss-Prot:P54983" /translation="MQKLSEEMKQTIMDIFEHLHANPEVSWKEYETTSFLKQKLEDLG CRTRTFSDCTGVVGEIGSGSPVVAVRADIDALWQEVNGTFRANHSCGHDSHMTMALGT LMLLKKQPELPKGTIRFIFQPAEEKGGGALKMIEEGVLDDIDYLYGVHVRPIQETQNG RCAPSILHGSSQHIEGTIIGEEAHGARPHLGKNSIEIAAFLVHKLGLIHIDPQIPHTV KMTKLQAGGESSNIIPGKASFSLDLRAQTNEAMEALIAETERACEAAAAAFGAKIELH KEHSLPAATQNKEAEAIMAEAITEIIGAERLDDPLVTTGGEDFHFYAVKVPNLKTTML GLGCGLQPGLHHPHMTFDRNAMFTGIHILANAVLKTFQKAESLAAANAS*" /label="amhX CDS" gene complement(305605..306756) /gene="amhX" /locus_tag="BSU_03010" /old_locus_tag="BSU03010" /label="amhX gene" downshifts complement(305624) /Source="Nicolas_upshifts" /id="D129" /incds=0 /nref=2 /ntot=70 /MaxReadThrough="4.33606" /MaxDrop="3.5225" /score="29.8489328" /energy="-12.2" /TU="U216" /idTUdmin="U216" /TUdmin="-264" /isTUend="FALSE" /label="downshifts" S_feature complement(306757..306844) /Source="Nicolas_S_feature" /locus_tag="new_325190_325277_c" /HighExp="Etha, T1.30H, M9-stat, T2.30H, S1, T3.30H, T5.0H, T4.0H, Sw, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S107" promotor_-35 306812..306819 /Source="Nicolas_upshift_promotors" /id="U217" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.758241758241758" /psig="0.999000999001" /xcortree=2902 /SigmaFactorBS="atttttaccttctttactttatttaTATTGAAAcaggaagat aggctGTATATAATATAGCACATATtgctactattcagaataattaatattttcaaac a" /listShort="ycgA" /listLong="ycgB, S108, amyE" /label="promotor_-35" promotor_-10 complement(306831..306850) /Source="Nicolas_upshift_promotors" /id="U216" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.632367632367632" /psig=1 /xcortree=2878 /SigmaFactorBS="tttcgatccatcccctctgtttgaaaatattaattATTCTGA atagtagcaataTGTGCTATATTATATACAGCctatcttcctgtttcaatataaataa a" /listShort="S107, amhX" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 306834..306853 /Source="Nicolas_upshift_promotors" /id="U217" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.758241758241758" /psig="0.999000999001" /xcortree=2902 /SigmaFactorBS="atttttaccttctttactttatttaTATTGAAAcaggaagat aggctGTATATAATATAGCACATATtgctactattcagaataattaatattttcaaac a" /listShort="ycgA" /listLong="ycgB, S108, amyE" /label="promotor_-10" upshifts complement(306844) /Source="Nicolas_upshifts" /id="U216" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.632367632367632" /psig=1 /xcortree=2878 /SigmaFactorBS="tttcgatccatcccctctgtttgaaaatattaattATTCTGA atagtagcaataTGTGCTATATTATATACAGCctatcttcctgtttcaatataaataa a" /listShort="S107, amhX" /GFF_Attribute="listLong" /label="upshifts" upshifts 306847 /Source="Nicolas_upshifts" /id="U217" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.758241758241758" /psig="0.999000999001" /xcortree=2902 /SigmaFactorBS="atttttaccttctttactttatttaTATTGAAAcaggaagat aggctGTATATAATATAGCACATATtgctactattcagaataattaatattttcaaac a" /listShort="ycgA" /listLong="ycgB, S108, amyE" /label="upshifts" promotor_-35 complement(306863..306869) /Source="Nicolas_upshift_promotors" /id="U216" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.632367632367632" /psig=1 /xcortree=2878 /SigmaFactorBS="tttcgatccatcccctctgtttgaaaatattaattATTCTGA atagtagcaataTGTGCTATATTATATACAGCctatcttcctgtttcaatataaataa a" /listShort="S107, amhX" /GFF_Attribute="listLong" /label="promotor_-35" CDS 306906..308339 /gene="ycgA" /locus_tag="BSU_03020" /old_locus_tag="BSU03020" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 21747963, 21764931; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative branched chain amino acid permease" /protein_id="NP_388184.2" /db_xref="EnsemblGenomes-Gn:BSU03020" /db_xref="EnsemblGenomes-Tr:CAB12096" /db_xref="GOA:P55908" /db_xref="InterPro:IPR018385" /db_xref="SubtiList:BG11999" /db_xref="UniProtKB/Swiss-Prot:P55908" /translation="MSMPAAETQPKKKRMTFKMPDAYVLLFMIAFICAIASYIVPAGE FDRVTKGDVTTAVPGSYHSIEQSPVRLISFFTSLQDGMVGSAPIIFLILFTGGTIAIL EKTGAINGLIYNVISKFRTKQLLFICIVGALFSILGTTGIVVNSVIGFIPIGLIVARS LKWDAVAGAAVIYIGCYAGFNSTILSPSPLGLSQSIAELPLFSGIGLRVVIYICFLLS SIIYIYLYTRKLKKSKDASVLGTDWFPAAGMGEAGKEEDQSVPFTVRHKLILAVAGLS LVGFLYGALKLGWSDSQMAATFIFISVLAGLIGGLAANDIAKTFITGCQSLVYGALIV GMARSISVILENGKLLDTVVNALASLLDGFSPIAGAIGMYIASALLHFLISSGSGEAV VFIPILAPLADLMGITRQVAVEAVMLGEGVVNCVNPTSGVLMAVLAASGIPYVKWLRF MVPLALIWFLIGLVFIVIGVMINWGPF*" /label="ycgA CDS" gene 306906..308339 /gene="ycgA" /locus_tag="BSU_03020" /old_locus_tag="BSU03020" /label="ycgA gene" promotor_-35 307644..307652 /Source="Nicolas_upshift_promotors" /id="U218" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=498 /SigmaFactorBS="ggaacagattggttccctgcgGCAGGAATGggcgaagccggT AAAGAAGAAGATCAGTCAgtgccgtttaccgttcgccataagctgattttggctgtgg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 307664..307682 /Source="Nicolas_upshift_promotors" /id="U218" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=498 /SigmaFactorBS="ggaacagattggttccctgcgGCAGGAATGggcgaagccggT AAAGAAGAAGATCAGTCAgtgccgtttaccgttcgccataagctgattttggctgtgg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 307683 /Source="Nicolas_upshifts" /id="U218" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=498 /SigmaFactorBS="ggaacagattggttccctgcgGCAGGAATGggcgaagccggT AAAGAAGAAGATCAGTCAgtgccgtttaccgttcgccataagctgattttggctgtgg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 308321 /Source="Nicolas_upshifts" /id="D130" /incds=0 /nref=1 /ntot=74 /MaxReadThrough="3.53497" /MaxDrop="3.31444" /score="12.0135493" /energy="-15.6" /TU="U217" /idTUdmin="U218" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 308382..308389 /Source="Nicolas_upshift_promotors" /id="U219" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig="0.999000999001" /xcortree=1929 /SigmaFactorBS="ccggcttgtacggcgggcttttgagttatTCATTGCAgaagc gcaggctgtTATTGTAACATGTAAGCCATaagccattcgtaaaagtgcgggaggaagg t" /listShort="ycgB, S108, amyE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 308404..308423 /Source="Nicolas_upshift_promotors" /id="U219" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig="0.999000999001" /xcortree=1929 /SigmaFactorBS="ccggcttgtacggcgggcttttgagttatTCATTGCAgaagc gcaggctgtTATTGTAACATGTAAGCCATaagccattcgtaaaagtgcgggaggaagg t" /listShort="ycgB, S108, amyE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 308413 /Source="Nicolas_upshifts" /id="U219" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig="0.999000999001" /xcortree=1929 /SigmaFactorBS="ccggcttgtacggcgggcttttgagttatTCATTGCAgaagc gcaggctgtTATTGTAACATGTAAGCCATaagccattcgtaaaagtgcgggaggaagg t" /listShort="ycgB, S108, amyE" /GFF_Attribute="listLong" /label="upshifts" CDS 308455..309036 /gene="ycgB" /locus_tag="BSU_03030" /old_locus_tag="BSU03030" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406, 22720735; Producttype m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein of unknown function" /protein_id="NP_388185.2" /db_xref="EnsemblGenomes-Gn:BSU03030" /db_xref="EnsemblGenomes-Tr:CAB12097" /db_xref="SubtiList:BG12000" /db_xref="UniProtKB/Swiss-Prot:P55909" /translation="MNNLRNRLSGVNGKNKRVKEKEQKIWSEIGMIAGAFALLDVIIR GIMFEFPFKEWAASLVFLFIIILYYCIRAAASGMLMPRIDTKEELQKRVKQQRIESIA VAFAVVVLTMYDRGIPHTFFAWLKMILLFIVCGGVLFLLRYVIVKLAYRRAVKEEIKK KSSFLFGKRGKRSQFRAAFFIGTLICIHSAKLF*" /label="ycgB CDS" gene 308455..309036 /gene="ycgB" /locus_tag="BSU_03030" /old_locus_tag="BSU03030" /label="ycgB gene" upshifts 308849 /Source="Nicolas_upshifts" /id="U220" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.288711288711289" /psig="0.241758241758242" /xcortree=1550 /SigmaFactorBS="tgtacgacagggggattccccatacattcttcgcttggctga aaatgattcttctttttatcgtCTGCGgcggcgttctgtttctgcttcggtatgtgat t" /listShort="S108, amyE" /GFF_Attribute="listLong" /label="upshifts" misc_feature 308853..308857 /Source="Nicolas_upshift_promotors" /id="U220" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.288711288711289" /psig="0.241758241758242" /xcortree=1550 /SigmaFactorBS="tgtacgacagggggattccccatacattcttcgcttggctga aaatgattcttctttttatcgtCTGCGgcggcgttctgtttctgcttcggtatgtgat t" /listShort="S108, amyE" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-35 309012..309019 /Source="Nicolas_upshift_promotors" /id="U221" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.892107892107892" /psig="0.999000999001" /xcortree=365 /SigmaFactorBS="ctttttttataggaacattgatttgTATTCACTctgccaagt tgtttTGATAGAGTGATTGTGATAAttttaaatgtaagcgttaacaaaattctccagt c" /listShort="S108, amyE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 309034..309053 /Source="Nicolas_upshift_promotors" /id="U221" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.892107892107892" /psig="0.999000999001" /xcortree=365 /SigmaFactorBS="ctttttttataggaacattgatttgTATTCACTctgccaagt tgtttTGATAGAGTGATTGTGATAAttttaaatgtaagcgttaacaaaattctccagt c" /listShort="S108, amyE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 309047..309184 /Source="Nicolas_S_feature" /locus_tag="new_327480_327617" /HighExp="BC, M0t90, M40t90, S2, M9-stat, T4.0H, Sw, T3.30H, Lbtran, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-, SigA" /TUshortPSig="0.999, 0.242, 0.999" /TUlongSig="SigA" /TUlongPSig="0.999" /label="S108" upshifts 309047 /Source="Nicolas_upshifts" /id="U221" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.892107892107892" /psig="0.999000999001" /xcortree=365 /SigmaFactorBS="ctttttttataggaacattgatttgTATTCACTctgccaagt tgtttTGATAGAGTGATTGTGATAAttttaaatgtaagcgttaacaaaattctccagt c" /listShort="S108, amyE" /GFF_Attribute="listLong" /label="upshifts" CDS 309185..311164 /gene="amyE" /locus_tag="BSU_03040" /old_locus_tag="BSU03040" /EC_number="3.2.1.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:3117969, 9353930" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3117969, 9353930; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alpha-amylase" /protein_id="NP_388186.2" /db_xref="EnsemblGenomes-Gn:BSU03040" /db_xref="EnsemblGenomes-Tr:CAB12098" /db_xref="GOA:P00691" /db_xref="InterPro:IPR006046" /db_xref="InterPro:IPR006047" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR031319" /db_xref="InterPro:IPR031965" /db_xref="PDB:1BAG" /db_xref="PDB:1UA7" /db_xref="SubtiList:BG10473" /db_xref="UniProtKB/Swiss-Prot:P00691" /translation="MFAKRFKTSLLPLFAGFLLLFHLVLAGPAAASAETANKSNELTA PSIKSGTILHAWNWSFNTLKHNMKDIHDAGYTAIQTSPINQVKEGNQGDKSMSNWYWL YQPTSYQIGNRYLGTEQEFKEMCAAAEEYGIKVIVDAVINHTTSDYAAISNEVKSIPN WTHGNTQIKNWSDRWDVTQNSLLGLYDWNTQNTQVQSYLKRFLDRALNDGADGFRFDA AKHIELPDDGSYGSQFWPNITNTSAEFQYGEILQDSASRDAAYANYMDVTASNYGHSI RSALKNRNLGVSNISHYASDVSADKLVTWVESHDTYANDDEESTWMSDDDIRLGWAVI ASRSGSTPLFFSRPEGGGNGVRFPGKSQIGDRGSALFEDQAITAVNRFHNVMAGQPEE LSNPNGNNQIFMNQRGSHGVVLANAGSSSVSINTATKLPDGRYDNKAGAGSFQVNDGK LTGTINARSVAVLYPDDIAKAPHVFLENYKTGVTHSFNDQLTITLRADANTTKAVYQI NNGPETAFKDGDQFTIGKGDPFGKTYTIMLKGTNSDGVTRTEKYSFVKRDPASAKTIG YQNPNHWSQVNAYIYKHDGSRVIELTGSWPGKPMTKNADGIYTLTLPADTDTTNAKVI FNNGSAQVPGQNQPGFDYVLNGLYNDSGLSGSLPH*" /label="amyE CDS" gene 309185..311164 /gene="amyE" /locus_tag="BSU_03040" /old_locus_tag="BSU03040" /label="amyE gene" downshifts 311178 /Source="Nicolas_upshifts" /id="D131" /incds=0 /nref=57 /ntot=131 /MaxReadThrough="1.64783" /MaxDrop="6.55823" /score="-8.82332571" /energy="-3.4" /TU="U221" /idTUdmin="U219" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 311244..311251 /Source="Nicolas_upshift_promotors" /id="U222" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.753246753246753" /psig=1 /xcortree=1599 /SigmaFactorBS="caatgatggtttcttttttgttcataaatcagacaaaacttt tCTCTTGCAaaagtttgtgaagTGTTGCACAATATAAATGTGaaatacttcacaaaca a" /listShort="ldh, lctP" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 311261 /Source="Nicolas_upshifts" /id="U222" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.753246753246753" /psig=1 /xcortree=1599 /SigmaFactorBS="caatgatggtttcttttttgttcataaatcagacaaaacttt tCTCTTGCAaaagtttgtgaagTGTTGCACAATATAAATGTGaaatacttcacaaaca a" /listShort="ldh, lctP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 311265..311284 /Source="Nicolas_upshift_promotors" /id="U222" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.753246753246753" /psig=1 /xcortree=1599 /SigmaFactorBS="caatgatggtttcttttttgttcataaatcagacaaaacttt tCTCTTGCAaaagtttgtgaagTGTTGCACAATATAAATGTGaaatacttcacaaaca a" /listShort="ldh, lctP" /GFF_Attribute="listLong" /label="promotor_-10" CDS 311341..312306 /gene="lctE" /locus_tag="BSU_03050" /old_locus_tag="BSU03050" /EC_number="1.1.1.27" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10809684, 16207915, 19383131" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10809684, 16207915, 19383131; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-lactate dehydrogenase" /protein_id="NP_388187.2" /db_xref="EnsemblGenomes-Gn:BSU03050" /db_xref="EnsemblGenomes-Tr:CAB12099" /db_xref="GOA:P13714" /db_xref="InterPro:IPR001236" /db_xref="InterPro:IPR001557" /db_xref="InterPro:IPR011304" /db_xref="InterPro:IPR015955" /db_xref="InterPro:IPR018177" /db_xref="InterPro:IPR022383" /db_xref="InterPro:IPR036291" /db_xref="PDB:3PQD" /db_xref="PDB:3PQE" /db_xref="PDB:3PQF" /db_xref="SubtiList:BG19003" /db_xref="UniProtKB/Swiss-Prot:P13714" /translation="MMNKHVNKVALIGAGFVGSSYAFALINQGITDELVVIDVNKEKA MGDVMDLNHGKAFAPQPVKTSYGTYEDCKDADIVCICAGANQKPGETRLELVEKNLKI FKGIVSEVMASGFDGIFLVATNPVDILTYATWKFSGLPKERVIGSGTTLDSARFRFML SEYFGAAPQNVHAHIIGEHGDTELPVWSHANVGGVPVSELVEKNDAYKQEELDQIVDD VKNAAYHIIEKKGATYYGVAMSLARITKAILHNENSILTVSTYLDGQYGADDVYIGVP AVVNRGGIAGITELNLNEKEKEQFLHSAGVLKNILKPHFAEQKVN*" /label="lctE CDS" gene 311341..312306 /gene="lctE" /locus_tag="BSU_03050" /old_locus_tag="BSU03050" /label="lctE gene" CDS 312338..313963 /gene="lctP" /locus_tag="BSU_03060" /old_locus_tag="BSU03060" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10809684, 15849754, 16428414, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10809684, 15849754, 16428414, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="L-lactate permease" /protein_id="NP_388188.2" /db_xref="EnsemblGenomes-Gn:BSU03060" /db_xref="EnsemblGenomes-Tr:CAB12100" /db_xref="GOA:P55910" /db_xref="InterPro:IPR003804" /db_xref="SubtiList:BG12001" /db_xref="UniProtKB/Swiss-Prot:P55910" /translation="MWEQLYDPFGNEYVSALVALTPILFFLLALTVLKMKGILAAFLT LAVSFFVSVWAFHMPVEKAISSVLLGIGSGLWPIGYIVLMAVWLYKIAVKTGKFTIIR SSIAGISPDQRLQLLLIGFCFNAFLEGAAGFGVPIAISAALLVELGFKPLKAAALCLI ANAASGAFGAIGIPVITGAQIGDLSALELSRTLMWTLPMISFLIPFLLVFLLDRMKGI KQTWPALLVVSGGYTAVQTLTMAVLGPELANILAALFSMGGLALFLRKWQPKEIYREE GAGDAGEKKAYRAADIAKAWSPFYILTAAITIWSLPAFKALFQEGGLLYQSTLLFKMP FLHQQIMKMPPIAPSAMPLDAVFKVDLLSATGTAILAAVIVTGLFSKKFSSRDAFASL KETGKELWVPIMTICFVMGFANLANFAGLSSSIGLALAKTGDLFPFVSPVLGWIGVFI TGSVVSNNALFGHLQVVTGAQIGAGSDLLLAANTAGGVMAKLVSPQSIAIAAAAVGQT GKESKLFKRTVAYSLILLLIICIWTFILARLGV*" /label="lctP CDS" gene 312338..313963 /gene="lctP" /locus_tag="BSU_03060" /old_locus_tag="BSU03060" /label="lctP gene" downshifts 312344 /Source="Nicolas_upshifts" /id="D132" /incds=0 /nref=1 /ntot=16 /MaxReadThrough="8.56142" /MaxDrop="2.8862" /score="-8.82332571" /energy="-3.4" /TU="U222" /idTUdmin="U221" /TUdmin=1144 /isTUend="FALSE" /label="downshifts" downshifts 313950 /Source="Nicolas_upshifts" /id="D133" /incds=0 /nref=51 /ntot=118 /MaxReadThrough="2.31168" /MaxDrop="7.73065" /score="39.575264" /energy="-15.6" /TU="NA" /idTUdmin="U222" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(314008..315546) /gene="mdr" /locus_tag="BSU_03070" /old_locus_tag="BSU03070" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9023234, 15489457, 15849754, 16850406, 21690368" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9023234, 15489457, 15849754, 16850406, 21690368; Product type t : transporter" /codon_start=1 /transl_table=11 /product="multidrug-efflux transporter" /protein_id="NP_388189.2" /db_xref="EnsemblGenomes-Gn:BSU03070" /db_xref="EnsemblGenomes-Tr:CAB12101" /db_xref="GOA:P96712" /db_xref="InterPro:IPR004638" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12002" /db_xref="UniProtKB/Swiss-Prot:P96712" /translation="MDTTTAKQASTKFVVLGLLLGILMSAMDNTIVATAMGNIVADLG SFDKFAWVTASYMVAVMAGMPIYGKLSDMYGRKRFFLFGLIFFLIGSALCGIAQTMNQ LIIFRAIQGIGGGALLPIAFTIIFDLFPPEKRGKMSGMFGAVFGLSSVLGPLLGAIIT DSISWHWVFYINVPIGALSLFFIIRYYKESLEHRKQKIDWGGAITLVVSIVCLMFALE LGGKTYDWNSIQIIGLFIVFAVFFIAFFIVERKAEEPIISFWMFKNRLFATAQILAFL YGGTFIILAVFIPIFVQAVYGSSATSAGFILTPMMIGSVIGSMIGGIFQTKASFRNLM LISVIAFFIGMLLLSNMTPDTARVWLTVFMMISGFGVGFNFSLLPAASMNDLEPRFRG TANSTNSFLRSFGMTLGVTIFGTVQTNVFTNKLNDAFSGMKGSAGSGAAQNIGDPQEI FQAGTRSQIPDAILNRIIDAMSSSITYVFLLALIPIVLAAVTILFMGKARVKTTAEMT KKAN*" /label="mdr CDS" gene complement(314008..315546) /gene="mdr" /locus_tag="BSU_03070" /old_locus_tag="BSU03070" /label="mdr gene" downshifts complement(314026) /Source="Nicolas_upshifts" /id="D134" /incds=0 /nref=70 /ntot=182 /MaxReadThrough="1.04964" /MaxDrop="4.53635" /score="30.8374042" /energy="-15.6" /TU="NA" /idTUdmin="U225" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_no_box complement(314600..314700) /Source="Nicolas_upshift_promotors" /id="U223" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.495504495504495" /psig="0.002997002997003" /xcortree=1728 /SigmaFactorBS="attttagcggtatttattccgattttcgttcaggcggtctac ggcagctcggcgacaagcgcgggcttcattctgacgccgatgatgattggatcagtca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(314640) /Source="Nicolas_upshifts" /id="U223" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.495504495504495" /psig="0.002997002997003" /xcortree=1728 /SigmaFactorBS="attttagcggtatttattccgattttcgttcaggcggtctac ggcagctcggcgacaagcgcgggcttcattctgacgccgatgatgattggatcagtca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 315560..315564 /Source="Nicolas_upshift_promotors" /id="U224" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.772227772227772" /psig="0.971028971028971" /xcortree=2583 /SigmaFactorBS="ttgttgtgtccatttgttctacctccTCTTActtttctatgt aagtTCTGATATCATGATAATAGTttgattgttgaatatctcgattatcaagataaac t" /listShort="ycgE, ycgF, ycgG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 315580..315599 /Source="Nicolas_upshift_promotors" /id="U224" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.772227772227772" /psig="0.971028971028971" /xcortree=2583 /SigmaFactorBS="ttgttgtgtccatttgttctacctccTCTTActtttctatgt aagtTCTGATATCATGATAATAGTttgattgttgaatatctcgattatcaagataaac t" /listShort="ycgE, ycgF, ycgG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 315594 /Source="Nicolas_upshifts" /id="U224" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.772227772227772" /psig="0.971028971028971" /xcortree=2583 /SigmaFactorBS="ttgttgtgtccatttgttctacctccTCTTActtttctatgt aagtTCTGATATCATGATAATAGTttgattgttgaatatctcgattatcaagataaac t" /listShort="ycgE, ycgF, ycgG" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(315626..315645) /Source="Nicolas_upshift_promotors" /id="U225" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.501498501498502" /psig="0.999000999001" /xcortree=2540 /SigmaFactorBS="ccaactcacttctggaatttcttGTTGACAactgacagtcct ccCTATAAAATCGAGTTTATCTtgataatcgagatattcaacaatcaaactattatca t" /listShort="mdr" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(315629) /Source="Nicolas_upshifts" /id="U225" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.501498501498502" /psig="0.999000999001" /xcortree=2540 /SigmaFactorBS="ccaactcacttctggaatttcttGTTGACAactgacagtcct ccCTATAAAATCGAGTTTATCTtgataatcgagatattcaacaatcaaactattatca t" /listShort="mdr" /GFF_Attribute="listLong" /label="upshifts" CDS 315659..316123 /gene="ycgE" /locus_tag="BSU_03080" /old_locus_tag="BSU03080" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_388190.2" /db_xref="EnsemblGenomes-Gn:BSU03080" /db_xref="EnsemblGenomes-Tr:CAB12102" /db_xref="GOA:O31472" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12003" /db_xref="UniProtKB/Swiss-Prot:O31472" /translation="MSTRNSRSELEKTAVQLFRKLGTRTVLFHQAAAQALGLFPTDLK SADILNEAGPMTAGELGKKTGLSTGSVTALVDRLEKAGYVAREKDPNDRRRVVIVPLT ASKKHIKDLFRPLSESTMDLCREYTEEELELIFSFVGKAADIMEEELERLKQ*" /label="ycgE CDS" gene 315659..316123 /gene="ycgE" /locus_tag="BSU_03080" /old_locus_tag="BSU03080" /label="ycgE gene" promotor_-35 complement(315660..315666) /Source="Nicolas_upshift_promotors" /id="U225" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.501498501498502" /psig="0.999000999001" /xcortree=2540 /SigmaFactorBS="ccaactcacttctggaatttcttGTTGACAactgacagtcct ccCTATAAAATCGAGTTTATCTtgataatcgagatattcaacaatcaaactattatca t" /listShort="mdr" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 316133..316138 /Source="Nicolas_upshift_promotors" /id="U226" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=970 /SigmaFactorBS="ttgaacgtctgaaacagtaagtgaatttgTGCATAgcttggc ccgttcccGAATAAATTGTACAAGTTAcataagagaagggagtacgggccggtgaaca t" /listShort="ycgF, ycgG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 316154..316172 /Source="Nicolas_upshift_promotors" /id="U226" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=970 /SigmaFactorBS="ttgaacgtctgaaacagtaagtgaatttgTGCATAgcttggc ccgttcccGAATAAATTGTACAAGTTAcataagagaagggagtacgggccggtgaaca t" /listShort="ycgF, ycgG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 316164 /Source="Nicolas_upshifts" /id="U226" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=970 /SigmaFactorBS="ttgaacgtctgaaacagtaagtgaatttgTGCATAgcttggc ccgttcccGAATAAATTGTACAAGTTAcataagagaagggagtacgggccggtgaaca t" /listShort="ycgF, ycgG" /GFF_Attribute="listLong" /label="upshifts" CDS 316197..316826 /gene="ycgF" /locus_tag="BSU_03090" /old_locus_tag="BSU03090" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative aminoacid export permease" /protein_id="NP_388191.1" /db_xref="EnsemblGenomes-Gn:BSU03090" /db_xref="EnsemblGenomes-Tr:CAB12103" /db_xref="GOA:P94381" /db_xref="InterPro:IPR001123" /db_xref="SubtiList:BG12004" /db_xref="UniProtKB/Swiss-Prot:P94381" /translation="MNIFLSYIVLGLSLSAPVGPVNAAQIDKGIKNGFWHAWIFGLGA MTADGLYMLFIYFGLSQFLTAPFVKTFLWLFGFFVLTYTGIETLKNVREPMDVRSSRG KPSYRKTFASGFLISLSNPLSILFWLGIYGSILAKTAEAYNMNQLLIYSSGIMIGILI WDFCMAITASTFRNLLHEKLLRGLTGIAGVSLLVFGFYFGYQGIKQLLG*" /label="ycgF CDS" gene 316197..316826 /gene="ycgF" /locus_tag="BSU_03090" /old_locus_tag="BSU03090" /label="ycgF gene" promotor_-35 316837..316846 /Source="Nicolas_upshift_promotors" /id="U227" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1281 /SigmaFactorBS="caaacagttattgggctgattcatgaaggACAGTCACCTgcc gcttccagttTTAATATAGTATCCAGATGAtactggaggtggatcaatggtgaatggg a" /listShort="ycgG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 316860..316879 /Source="Nicolas_upshift_promotors" /id="U227" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1281 /SigmaFactorBS="caaacagttattgggctgattcatgaaggACAGTCACCTgcc gcttccagttTTAATATAGTATCCAGATGAtactggaggtggatcaatggtgaatggg a" /listShort="ycgG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 316868 /Source="Nicolas_upshifts" /id="U227" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1281 /SigmaFactorBS="caaacagttattgggctgattcatgaaggACAGTCACCTgcc gcttccagttTTAATATAGTATCCAGATGAtactggaggtggatcaatggtgaatggg a" /listShort="ycgG" /GFF_Attribute="listLong" /label="upshifts" CDS 316896..317657 /gene="ycgG" /locus_tag="BSU_03100" /old_locus_tag="BSU03100" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (similar to phage protein)" /protein_id="NP_388192.2" /db_xref="EnsemblGenomes-Gn:BSU03100" /db_xref="EnsemblGenomes-Tr:CAB12104" /db_xref="InterPro:IPR014988" /db_xref="SubtiList:BG12005" /db_xref="UniProtKB/Swiss-Prot:P94382" /translation="MVNGIYTKSFLERIQEELPEWQRIAFELLAETLGDDADTFPCIP GRQAFLTDQLRIAFAGDPRENRTAEELAPLLAEYGKISRDTGKYASLVVLFDTPEDLA EHYSIEAYEELFWRFLNRLSHQDEKEWPEDIPADPEHYKWEFCFDGEPYFILCATPGH EARRSRSFPFFMVTFQPRWVFDDLNGSTAFGRNMSRLIRSRLEAYDQAPIHPQLGWYG GKDNREWKQYFLRDDEKQVSKCPFSYLKNMFNKMK*" /label="ycgG CDS" gene 316896..317657 /gene="ycgG" /locus_tag="BSU_03100" /old_locus_tag="BSU03100" /label="ycgG gene" S_feature complement(317296..317658) /Source="Nicolas_S_feature" /locus_tag="new_335729_336091_c" /HighExp="S8, S7, S5, S6, S4, nit, ferm, BT, Pyr, G/S" /AntisenseName="ycgG" /AntisenseCor="0.73875580854115197" /AntisenseRegPval="-46.9" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S109" downshifts 317654 /Source="Nicolas_upshifts" /id="D135" /incds=0 /nref=21 /ntot=174 /MaxReadThrough="1.53211" /MaxDrop="4.92685" /score="6.36985882" /energy="-8.6" /TU="NA" /idTUdmin="U227" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" CDS complement(317659..318999) /gene="ycgH" /locus_tag="BSU_03110" /old_locus_tag="BSU03110" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative amino acid transporter" /protein_id="NP_388193.2" /db_xref="EnsemblGenomes-Gn:BSU03110" /db_xref="EnsemblGenomes-Tr:CAB12105" /db_xref="GOA:P94383" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG12006" /db_xref="UniProtKB/Swiss-Prot:P94383" /translation="MSQTKKDQPKGNLAWWQLSLIGVGCTIGTGFFLGSSIAIVKSGF SVLLSFLIAGIGTYFVFEQLAKLSAKQPEKGSFCAYARKAFGKWAGFSNGWVYWTSEM LITGSQLTAISLFTKHWFPQVPLWVFASIYAVLGLLIIFTGLSVFEKTENVLAVIKTA AIFMFIVIAILALCGILSGGNHGIHVPNKTSEFFPYGAMGLWTGLIYAFYAFGGIEVM GLMAVHLKKPEEASKSGKLMLATLAIIYIISIGLALLLVPLHTFTEQDSPFITSLKGY NLEIILDIFNGIFIIAGFSTLVASLFAVTTLLCTMADDGDAPKCFTLKEGKKICWPAL GLTFAGLVLSIILSLVLPKNIYEHMTTAAGLMLLYTWLFILFSSKKLTDPEGMGKTQI YLAMVLIAAAVSGTLFEKSSRPGFFVSIGFLVIIAIVTMIYQKKQGHKDRPASP*" /label="ycgH CDS" gene complement(317659..318999) /gene="ycgH" /locus_tag="BSU_03110" /old_locus_tag="BSU03110" /label="ycgH gene" promotor_-10 complement(319026..319037) /Source="Nicolas_upshift_promotors" /id="U228" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=918 /SigmaFactorBS="ctgcttccttctccatgtaaaaagaggcaaaaatccgaTGTA TATaagctttggacagaTCACAATCTAACcttagataaaaggggttgaataaataatg a" /listShort="ycgH, S109" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(319036) /Source="Nicolas_upshifts" /id="U228" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=918 /SigmaFactorBS="ctgcttccttctccatgtaaaaagaggcaaaaatccgaTGTA TATaagctttggacagaTCACAATCTAACcttagataaaaggggttgaataaataatg a" /listShort="ycgH, S109" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(319052..319058) /Source="Nicolas_upshift_promotors" /id="U228" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=918 /SigmaFactorBS="ctgcttccttctccatgtaaaaagaggcaaaaatccgaTGTA TATaagctttggacagaTCACAATCTAACcttagataaaaggggttgaataaataatg a" /listShort="ycgH, S109" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 319078..319084 /Source="Nicolas_upshift_promotors" /id="U229" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=817 /SigmaFactorBS="ttgtgatctgtccaaagcttatatacatcggatttttgcctc ttttTACATGGagaaggaagcagacGCTCATACTAATgaaaaaaggagcaaaccaatg a" /listShort="ycgI" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 319092 /Source="Nicolas_upshifts" /id="U229" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=817 /SigmaFactorBS="ttgtgatctgtccaaagcttatatacatcggatttttgcctc ttttTACATGGagaaggaagcagacGCTCATACTAATgaaaaaaggagcaaaccaatg a" /listShort="ycgI" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 319099..319110 /Source="Nicolas_upshift_promotors" /id="U229" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=817 /SigmaFactorBS="ttgtgatctgtccaaagcttatatacatcggatttttgcctc ttttTACATGGagaaggaagcagacGCTCATACTAATgaaaaaaggagcaaaccaatg a" /listShort="ycgI" /GFF_Attribute="listLong" /label="promotor_-10" CDS 319129..319725 /gene="ycgI" /locus_tag="BSU_03120" /old_locus_tag="BSU03120" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 16433904, 28898812; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xenotiotic metabolite methyltransferase" /protein_id="NP_388194.3" /db_xref="EnsemblGenomes-Gn:BSU03120" /db_xref="EnsemblGenomes-Tr:CAB12106" /db_xref="InterPro:IPR018959" /db_xref="SubtiList:BG12007" /db_xref="UniProtKB/Swiss-Prot:O31473" /translation="MTQQYIVEPKKGLGLKLKKGQILKVVDVEGQQVADFVAYHAKDF YEHLDQGATIDANHSIHVKVNDHLYSNLYKPMLTLIEDTVGKHDLLLPACRPDMNRLL YGKQKDEFQDTCYDNMNRALEQFGVPKPHMHYPFAIFMNTVLDEKGNLSVETPLSNAG DYVRLRAEMDLIVAFSSCPIEKGKCNGDSVTSIRVEVS*" /label="ycgI CDS" gene 319129..319725 /gene="ycgI" /locus_tag="BSU_03120" /old_locus_tag="BSU03120" /label="ycgI gene" promotor_-35 319733..319740 /Source="Nicolas_upshift_promotors" /id="U230" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.471528471528472" /psig="0.99100899100899" /xcortree=104 /SigmaFactorBS="gtgtgacatccatacgggttgaagtcagctgatctctctTGT TCACAgtgaatgaagaccTGTGCTATATTTAATAGGGAtacataacagtcatgattca t" /listShort="S110, nadE" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 319754..319854 /Source="Nicolas_S_feature" /locus_tag="new_338187_338287" /HighExp="dia15, LBGtran, dia5, Etha, dia0, LBGexp, M0t45, Lbexp, Diami, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.991" /TUlongSig="NA" /TUlongPSig="NA" /label="S110" promotor_-10 319754..319773 /Source="Nicolas_upshift_promotors" /id="U230" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.471528471528472" /psig="0.99100899100899" /xcortree=104 /SigmaFactorBS="gtgtgacatccatacgggttgaagtcagctgatctctctTGT TCACAgtgaatgaagaccTGTGCTATATTTAATAGGGAtacataacagtcatgattca t" /listShort="S110, nadE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 319754 /Source="Nicolas_upshifts" /id="U230" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.471528471528472" /psig="0.99100899100899" /xcortree=104 /SigmaFactorBS="gtgtgacatccatacgggttgaagtcagctgatctctctTGT TCACAgtgaatgaagaccTGTGCTATATTTAATAGGGAtacataacagtcatgattca t" /listShort="S110, nadE" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(319850) /Source="Nicolas_upshifts" /id="D136" /incds=0 /nref=3 /ntot=24 /MaxReadThrough="1.2989" /MaxDrop="4.67402" /score="15.0992897" /energy="-14.1" /TU="NA" /idTUdmin="U233" /TUdmin=1562 /isTUend="FALSE" /label="downshifts" CDS 319855..320673 /gene="nadE" /locus_tag="BSU_03130" /old_locus_tag="BSU03130" /EC_number="6.3.1.5" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7890752, 9271869, 12682299, 19204287" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7890752, 9271869, 12682299, 19204287; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ammonium-dependent NAD+ synthetase" /protein_id="NP_388195.1" /db_xref="EnsemblGenomes-Gn:BSU03130" /db_xref="EnsemblGenomes-Tr:CAB12107" /db_xref="GOA:P08164" /db_xref="InterPro:IPR003694" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR022310" /db_xref="InterPro:IPR022926" /db_xref="PDB:1EE1" /db_xref="PDB:1FYD" /db_xref="PDB:1IFX" /db_xref="PDB:1IH8" /db_xref="PDB:1KQP" /db_xref="PDB:1NSY" /db_xref="PDB:2NSY" /db_xref="SubtiList:BG10694" /db_xref="UniProtKB/Swiss-Prot:P08164" /translation="MSMQEKIMRELHVKPSIDPKQEIEDRVNFLKQYVKKTGAKGFVL GISGGQDSTLAGRLAQLAVESIREEGGDAQFIAVRLPHGTQQDEDDAQLALKFIKPDK SWKFDIKSTVSAFSDQYQQETGDQLTDFNKGNVKARTRMIAQYAIGGQEGLLVLGTDH AAEAVTGFFTKYGDGGADLLPLTGLTKRQGRTLLKELGAPERLYLKEPTADLLDEKPQ QSDETELGISYDEIDDYLEGKEVSAKVSEALEKRYSMTEHKRQVPASMFDDWWK*" /label="nadE CDS" gene 319855..320673 /gene="nadE" /locus_tag="BSU_03130" /old_locus_tag="BSU03130" /label="nadE gene" downshifts 320655 /Source="Nicolas_upshifts" /id="D137" /incds=0 /nref=144 /ntot=271 /MaxReadThrough="2.68866" /MaxDrop="6.24927" /score="20.6612287" /energy="-14.1" /TU="U230" /idTUdmin="U230" /TUdmin="-65" /isTUend="FALSE" /label="downshifts" CDS complement(320723..321316) /gene="tmrB" /locus_tag="BSU_03140" /old_locus_tag="BSU03140" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:1624425, 7766032, 15131133, 27315722" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1624425, 7766032, 15131133, 27315722; Product type f: factor" /codon_start=1 /transl_table=11 /product="ATP-binding tunicamycin resistance protein" /protein_id="NP_388196.2" /db_xref="EnsemblGenomes-Gn:BSU03140" /db_xref="EnsemblGenomes-Tr:CAB12108" /db_xref="GOA:P12921" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10456" /db_xref="UniProtKB/Swiss-Prot:P12921" /translation="MIIWINGAFGSGKTQTAFELHRRLNPSYVYDPEKMGFALRSMVP QEIAKDDFQSYPLWRAFNYSLLASLTDTYRGILIVPMTIVHPEYFNEIIGRLRQEGRI VHHFTLMASKETLLKRLRTRAEGKNSWAAKQIDRCVEGLSSPIFEDHIQTDNLSIQDV AENIAARAELPLDPDTRGSLRRFADRLMVKLNHIRIK*" /label="tmrB CDS" gene complement(320723..321316) /gene="tmrB" /locus_tag="BSU_03140" /old_locus_tag="BSU03140" /label="tmrB gene" downshifts complement(320730) /Source="Nicolas_upshifts" /id="D138" /incds=0 /nref=10 /ntot=143 /MaxReadThrough="0.60282" /MaxDrop="3.74815" /score="15.0992897" /energy="-14.1" /TU="NA" /idTUdmin="U233" /TUdmin=682 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(321331..321350) /Source="Nicolas_upshift_promotors" /id="U231" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.999000999001" /xcortree=3131 /SigmaFactorBS="gttaaaaccttccgcctttattgtttttccagctgactCTTC gatggaagggtcttTTTCTGTATGATAAATAGGAagggagaaatggcgatgatcattt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(321346) /Source="Nicolas_upshifts" /id="U231" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.999000999001" /xcortree=3131 /SigmaFactorBS="gttaaaaccttccgcctttattgtttttccagctgactCTTC gatggaagggtcttTTTCTGTATGATAAATAGGAagggagaaatggcgatgatcattt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(321365..321368) /Source="Nicolas_upshift_promotors" /id="U231" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.999000999001" /xcortree=3131 /SigmaFactorBS="gttaaaaccttccgcctttattgtttttccagctgactCTTC gatggaagggtcttTTTCTGTATGATAAATAGGAagggagaaatggcgatgatcattt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(321374..321522) /Source="Nicolas_S_feature" /locus_tag="new_339807_339955_c" /HighExp="S4, S3, S6, S5, S7, BT, S8, LoTm, T5.0H, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S111" promotor_-35 321424..321431 /Source="Nicolas_upshift_promotors" /id="U232" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.495504495504495" /psig="0.997002997002997" /xcortree=3017 /SigmaFactorBS="aaaggcggaaggttttaacgcttttttgcgtcgaagTATTAA AAtacctgcagaaaTGTTGTACAATGAATGTCATtcaggcaaaaatggctacaacaaa g" /listShort="S112, aroK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 321444..321463 /Source="Nicolas_upshift_promotors" /id="U232" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.495504495504495" /psig="0.997002997002997" /xcortree=3017 /SigmaFactorBS="aaaggcggaaggttttaacgcttttttgcgtcgaagTATTAA AAtacctgcagaaaTGTTGTACAATGAATGTCATtcaggcaaaaatggctacaacaaa g" /listShort="S112, aroK" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 321446..321554 /Source="Nicolas_S_feature" /locus_tag="new_339879_339987" /HighExp="Diami, BMM, GM 15, GM 25, GM 120, GM 60, GM 10, G180, GM 45, M9-exp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S112" upshifts 321448 /Source="Nicolas_upshifts" /id="U232" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.495504495504495" /psig="0.997002997002997" /xcortree=3017 /SigmaFactorBS="aaaggcggaaggttttaacgcttttttgcgtcgaagTATTAA AAtacctgcagaaaTGTTGTACAATGAATGTCATtcaggcaaaaatggctacaacaaa g" /listShort="S112, aroK" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(321516..321534) /Source="Nicolas_upshift_promotors" /id="U233" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1121 /SigmaFactorBS="tcttcggcgaaatcctcctaaggaatgaaattatataTTCAT TatatgcttatttagcGAATATTTATATAGATACCggctttaccggtcaagcttatag t" /listShort="S111" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 321522..321529 /Source="Nicolas_upshift_promotors" /id="U234" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.943056943056943" /psig="0.988011988011988" /xcortree=1750 /SigmaFactorBS="taagcttgaccggtaaagccggtatcTATATAAAtattcgct aaataaGCATATAATGAATATATAATttcattccttaggaggatttcgccgaagatga a" /listShort="aroK" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(321532) /Source="Nicolas_upshifts" /id="U233" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1121 /SigmaFactorBS="tcttcggcgaaatcctcctaaggaatgaaattatataTTCAT TatatgcttatttagcGAATATTTATATAGATACCggctttaccggtcaagcttatag t" /listShort="S111" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 321544..321563 /Source="Nicolas_upshift_promotors" /id="U234" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.943056943056943" /psig="0.988011988011988" /xcortree=1750 /SigmaFactorBS="taagcttgaccggtaaagccggtatcTATATAAAtattcgct aaataaGCATATAATGAATATATAATttcattccttaggaggatttcgccgaagatga a" /listShort="aroK" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(321550..321555) /Source="Nicolas_upshift_promotors" /id="U233" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1121 /SigmaFactorBS="tcttcggcgaaatcctcctaaggaatgaaattatataTTCAT TatatgcttatttagcGAATATTTATATAGATACCggctttaccggtcaagcttatag t" /listShort="S111" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 321556 /Source="Nicolas_upshifts" /id="U234" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.943056943056943" /psig="0.988011988011988" /xcortree=1750 /SigmaFactorBS="taagcttgaccggtaaagccggtatcTATATAAAtattcgct aaataaGCATATAATGAATATATAATttcattccttaggaggatttcgccgaagatga a" /listShort="aroK" /GFF_Attribute="listLong" /label="upshifts" CDS 321592..322152 /gene="aroK" /locus_tag="BSU_03150" /old_locus_tag="BSU03150" /EC_number="2.7.1.71" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 170268, 7612934, 27339308; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="shikimate kinase" /protein_id="NP_388197.2" /db_xref="EnsemblGenomes-Gn:BSU03150" /db_xref="EnsemblGenomes-Tr:CAB12109" /db_xref="GOA:P37944" /db_xref="InterPro:IPR000623" /db_xref="InterPro:IPR023000" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031322" /db_xref="SubtiList:BG10457" /db_xref="UniProtKB/Swiss-Prot:P37944" /translation="MNAKRAIPVRERNIVLIGFMGVGKTTIGQLVAKKLYRDFIDIDQ QIEKDFNMSIPEIFEKKGEDFFRKTEKEYILDICHHKRFKIVSLGGGSFKQEEIRNCC LENCLVLHLDLSWENWKQRADLLIESRPVLHNRSMDEMEQLFNERKVIYDKHNSKVAT DNLSPEEVADYIVETLKIGWDLYQPM*" /label="aroK CDS" gene 321592..322152 /gene="aroK" /locus_tag="BSU_03150" /old_locus_tag="BSU03150" /label="aroK gene" downshifts 322129 /Source="Nicolas_upshifts" /id="D139" /incds=0 /nref=21 /ntot=239 /MaxReadThrough="2.07607" /MaxDrop="4.67156" /score="44.9099474" /energy="-13.1" /TU="NA" /idTUdmin="U232" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(322180..322941) /gene="ycgJ" /locus_tag="BSU_03160" /old_locus_tag="BSU03160" /EC_number="2.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 28898812; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xenotiotic metabolite methyltransferase" /protein_id="NP_388198.2" /db_xref="EnsemblGenomes-Gn:BSU03160" /db_xref="EnsemblGenomes-Tr:CAB12110" /db_xref="GOA:O31474" /db_xref="InterPro:IPR013216" /db_xref="InterPro:IPR029063" /db_xref="PDB:1XXL" /db_xref="PDB:2GLU" /db_xref="SubtiList:BG12008" /db_xref="UniProtKB/Swiss-Prot:O31474" /translation="MTNETPFSKNAEMYRDEKVFAEGEDLGLMIKTAECRAEHRVLDI GAGAGHTALAFSPYVQECIGVDATKEMVEVASSFAQEKGVENVRFQQGTAESLPFPDD SFDIITCRYAAHHFSDVRKAVREVARVLKQDGRFLLVDHYAPEDPVLDEFVNHLNRLR DPSHVRESSLSEWQAMFSANQLAYQDIQKWNLPIQYDSWIKRGGTPADREKQIITHLN HASDEARDTFCITLNQNGQPISFCLKAILIQGIKR*" /label="ycgJ CDS" gene complement(322180..322941) /gene="ycgJ" /locus_tag="BSU_03160" /old_locus_tag="BSU03160" /label="ycgJ gene" downshifts complement(322204) /Source="Nicolas_upshifts" /id="D140" /incds=0 /nref=3 /ntot=55 /MaxReadThrough="0.31391" /MaxDrop="3.85249" /score="18.9843263" /energy="-13.1" /TU="NA" /idTUdmin="U235" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(322973..322992) /Source="Nicolas_upshift_promotors" /id="U235" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.392607392607393" /psig="0.942057942057942" /xcortree=1808 /SigmaFactorBS="acctatcattttcatcatttttatatcTTGGACgaatcataa cagaaATTGCTAACATAATCCATATcatcatttacgaaaagaaggagctggttcaaat g" /listShort="ycgJ" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 322974..322981 /Source="Nicolas_upshift_promotors" /id="U236" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.662337662337662" /psig="0.983016983016983" /xcortree=1867 /SigmaFactorBS="cagctccttcttttcgtaaatgatgaTATGGATTatgttagc aatttcTGTTATGATTCGTCCAAGATataaaaatgatgaaaatgataggttcaaccta t" /listShort="ycgK, S113, cah, S114, ycgL" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(322979) /Source="Nicolas_upshifts" /id="U235" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.392607392607393" /psig="0.942057942057942" /xcortree=1808 /SigmaFactorBS="acctatcattttcatcatttttatatcTTGGACgaatcataa cagaaATTGCTAACATAATCCATATcatcatttacgaaaagaaggagctggttcaaat g" /listShort="ycgJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 322996..323015 /Source="Nicolas_upshift_promotors" /id="U236" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.662337662337662" /psig="0.983016983016983" /xcortree=1867 /SigmaFactorBS="cagctccttcttttcgtaaatgatgaTATGGATTatgttagc aatttcTGTTATGATTCGTCCAAGATataaaaatgatgaaaatgataggttcaaccta t" /listShort="ycgK, S113, cah, S114, ycgL" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(323007..323012) /Source="Nicolas_upshift_promotors" /id="U235" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.392607392607393" /psig="0.942057942057942" /xcortree=1808 /SigmaFactorBS="acctatcattttcatcatttttatatcTTGGACgaatcataa cagaaATTGCTAACATAATCCATATcatcatttacgaaaagaaggagctggttcaaat g" /listShort="ycgJ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 323008 /Source="Nicolas_upshifts" /id="U236" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.662337662337662" /psig="0.983016983016983" /xcortree=1867 /SigmaFactorBS="cagctccttcttttcgtaaatgatgaTATGGATTatgttagc aatttcTGTTATGATTCGTCCAAGATataaaaatgatgaaaatgataggttcaaccta t" /listShort="ycgK, S113, cah, S114, ycgL" /GFF_Attribute="listLong" /label="upshifts" CDS 323059..324033 /gene="ycgK" /locus_tag="BSU_03170" /old_locus_tag="BSU03170" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10939241; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (LysR family)" /protein_id="NP_388199.2" /db_xref="EnsemblGenomes-Gn:BSU03170" /db_xref="EnsemblGenomes-Tr:CAB12111" /db_xref="GOA:P94387" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12009" /db_xref="UniProtKB/Swiss-Prot:P94387" /translation="MDIKVMEYAAEIARRQSFTKAAEHLHIAQPSLSQQIKKLEAELG LTLFHRSHGSVTLTPHGRRFIEKAEDIIRSRDDLLREMQERSQGIGHKLSIGIPAVTG RYLFPPLLKQFLARYPHVEVQLVEKDPVSLEKMTAKGEVDLSVLSLPIEDERLSITPL LTEPVVLAVPKEKQRWMPPELVALIEKALEEDEGRQPCVPIDMVRNVPFILLKEGFGF RRTVLDLCAESGFKPNAAFKTSHIETAQSLVANGLGVTMAPNMVRRDKDPGVIYLSIQ SAPSRTLVFVFLKNRYVSLTAQAFMELSRESLKQTFDEGCLGNKDENI*" /label="ycgK CDS" gene 323059..324033 /gene="ycgK" /locus_tag="BSU_03170" /old_locus_tag="BSU03170" /label="ycgK gene" S_feature 324034..324104 /Source="Nicolas_S_feature" /locus_tag="new_342467_342537" /HighExp="Diami, dia5, dia15, S1, dia0, C90, LBGexp, Heat, Lbexp, GM 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.983" /TUlongSig="NA" /TUlongPSig="NA" /label="S113" CDS 324105..325061 /gene="cah" /locus_tag="BSU_03180" /old_locus_tag="BSU03180" /EC_number="3.1.1.41" /EC_number="3.1.1.72" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12842474, 19837798, 21382014" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12842474, 19837798, 21382014; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous acetyl xylan esterase-cephalosporin C deacetylase" /protein_id="NP_388200.1" /db_xref="EnsemblGenomes-Gn:BSU03180" /db_xref="EnsemblGenomes-Tr:CAB12112" /db_xref="GOA:P94388" /db_xref="InterPro:IPR008391" /db_xref="InterPro:IPR029058" /db_xref="PDB:1L7A" /db_xref="PDB:1ODS" /db_xref="PDB:1ODT" /db_xref="SubtiList:BG11919" /db_xref="UniProtKB/Swiss-Prot:P94388" /translation="MQLFDLPLDQLQTYKPEKTAPKDFSEFWKLSLEELAKVQAEPDL QPVDYPADGVKVYRLTYKSFGNARITGWYAVPDKEGPHPAIVKYHGYNASYDGEIHEM VNWALHGYATFGMLVRGQQSSEDTSISPHGHALGWMTKGILDKDTYYYRGVYLDAVRA LEVISSFDEVDETRIGVTGGSQGGGLTIAAAALSDIPKAAVADYPYLSNFERAIDVAL EQPYLEINSFFRRNGSPETEVQAMKTLSYFDIMNLADRVKVPVLMSIGLIDKVTPPST VFAAYNHLETKKELKVYRYFGHEYIPAFQTEKLAFFKQHLKG*" /label="cah CDS" gene 324105..325061 /gene="cah" /locus_tag="BSU_03180" /old_locus_tag="BSU03180" /label="cah gene" promotor_-35 324520..324526 /Source="Nicolas_upshift_promotors" /id="U237" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=806 /SigmaFactorBS="ttcaccgcacggtcacgctttgggctggatgaCGAAAGGaat tcttgataaagATACATACTATTaccgcggtgtttatttggacgccgtccgcgcgctt g" /listShort="S114, ycgL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 324541..324552 /Source="Nicolas_upshift_promotors" /id="U237" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=806 /SigmaFactorBS="ttcaccgcacggtcacgctttgggctggatgaCGAAAGGaat tcttgataaagATACATACTATTaccgcggtgtttatttggacgccgtccgcgcgctt g" /listShort="S114, ycgL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 324548 /Source="Nicolas_upshifts" /id="U237" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=806 /SigmaFactorBS="ttcaccgcacggtcacgctttgggctggatgaCGAAAGGaat tcttgataaagATACATACTATTaccgcggtgtttatttggacgccgtccgcgcgctt g" /listShort="S114, ycgL" /GFF_Attribute="listLong" /label="upshifts" S_feature 325062..325140 /Source="Nicolas_S_feature" /locus_tag="new_343495_343573" /HighExp="dia5, dia15, Diami, dia0, B36, S1, MG 10, BT, B60, MG t5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigA" /TUshortPSig="0.998, 0.983" /TUlongSig="NA" /TUlongPSig="NA" /label="S114" promotor_-35 325115..325120 /Source="Nicolas_upshift_promotors" /id="U238" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1193 /SigmaFactorBS="atatcatcaggcggtttttttctgcaaactgccGGAATGaga acagactggagacGAATAGATATGAAACAAAGaatcattgatgaattaaaacggatcg a" /listShort="ycgL, S115, ycgM, ycgN, S116, ycgO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 325137..325155 /Source="Nicolas_upshift_promotors" /id="U238" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1193 /SigmaFactorBS="atatcatcaggcggtttttttctgcaaactgccGGAATGaga acagactggagacGAATAGATATGAAACAAAGaatcattgatgaattaaaacggatcg a" /listShort="ycgL, S115, ycgM, ycgN, S116, ycgO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 325142 /Source="Nicolas_upshifts" /id="U238" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1193 /SigmaFactorBS="atatcatcaggcggtttttttctgcaaactgccGGAATGaga acagactggagacGAATAGATATGAAACAAAGaatcattgatgaattaaaacggatcg a" /listShort="ycgL, S115, ycgM, ycgN, S116, ycgO" /GFF_Attribute="listLong" /label="upshifts" CDS 325145..325927 /gene="ycgL" /locus_tag="BSU_03190" /old_locus_tag="BSU03190" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388201.1" /db_xref="EnsemblGenomes-Gn:BSU03190" /db_xref="EnsemblGenomes-Tr:CAB12113" /db_xref="InterPro:IPR018775" /db_xref="SubtiList:BG12010" /db_xref="UniProtKB/Swiss-Prot:P94389" /translation="MKQRIIDELKRIEQSYGVKIVYAVESGSRAWGFPSQDSDYDVRF IYVPKKEWYFSIEQERDVIEEPIHDLLDISGWELRKTLRLFKKSNPPLLEWLSSDIVY YEAFTTAEQLRKLRTEAFKPEASVYHYINMARRNVKDYLQGQEVKIKKYFYVLRPILA CQWIEKHGTIPPMDFTVLMNELVAEPELKAEMETLLERKRRGEELDLEARIDVIHQFI ETEIERIMEAAKELKAEKKDMTSELNRLLLNTVEEVWKDGGS*" /label="ycgL CDS" gene 325145..325927 /gene="ycgL" /locus_tag="BSU_03190" /old_locus_tag="BSU03190" /label="ycgL gene" downshifts 325892 /Source="Nicolas_upshifts" /id="D141" /incds=0 /nref=11 /ntot=63 /MaxReadThrough="3.94077" /MaxDrop="4.37398" /score="0.421649027" /energy="-5.9" /TU="U238" /idTUdmin="U236" /TUdmin=2 /isTUend="TRUE" /label="downshifts" S_feature 325937..326064 /Source="Nicolas_S_feature" /locus_tag="new_344370_344497" /HighExp="S5, S6, S8, S4, S7, B36, B60, BT, S3, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S115" promotor_-35 326041..326045 /Source="Nicolas_upshift_promotors" /id="U239" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.472527472527473" /psig="0.922077922077922" /xcortree=391 /SigmaFactorBS="cacaaaaataatcagaatctttgtattttgagaatATTGTga acgctggttttgTCCATTTACAATAAACTCATacaaatacttcttagattgcggggtg t" /listShort="ycgM, ycgN, S116, ycgO, S118, ycgP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 326060..326079 /Source="Nicolas_upshift_promotors" /id="U239" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.472527472527473" /psig="0.922077922077922" /xcortree=391 /SigmaFactorBS="cacaaaaataatcagaatctttgtattttgagaatATTGTga acgctggttttgTCCATTTACAATAAACTCATacaaatacttcttagattgcggggtg t" /listShort="ycgM, ycgN, S116, ycgO, S118, ycgP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 326066 /Source="Nicolas_upshifts" /id="U239" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.472527472527473" /psig="0.922077922077922" /xcortree=391 /SigmaFactorBS="cacaaaaataatcagaatctttgtattttgagaatATTGTga acgctggttttgTCCATTTACAATAAACTCATacaaatacttcttagattgcggggtg t" /listShort="ycgM, ycgN, S116, ycgO, S118, ycgP" /GFF_Attribute="listLong" /label="upshifts" CDS 326118..327029 /gene="putB" /locus_tag="BSU_03200" /old_locus_tag="BSU03200" /EC_number="1.5.5.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17536821, 2118500, 21840319, 22139509, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17536821, 2118500, 21840319, 22139509, 26735940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="proline oxidase" /protein_id="NP_388202.1" /db_xref="EnsemblGenomes-Gn:BSU03200" /db_xref="EnsemblGenomes-Tr:CAB12114" /db_xref="GOA:P94390" /db_xref="InterPro:IPR002872" /db_xref="InterPro:IPR008219" /db_xref="InterPro:IPR015659" /db_xref="InterPro:IPR029041" /db_xref="SubtiList:BG12011" /db_xref="UniProtKB/Swiss-Prot:P94390" /translation="MITRDFFLFLSKSGFLNKMARNWGSRVAAGKIIGGNDFNSSIPT IRQLNSQGLSVTVDHLGEFVNSAEVARERTEECIQTIATIADQELNSHVSLKMTSLGL DIDMDLVYENMTKILQTAEKHKIMVTIDMEDEVRCQKTLDIFKDFRKKYEHVSTVLQA YLYRTEKDIDDLDSLNPFLRLVKGAYKESEKVAFPEKSDVDENYKKIIRKQLLNGHYT AIATHDDKMIDFTKQLAKEHGIANDKFEFQMLYGMRSQTQLSLVKEGYNMRVYLPYGE DWYGYFMRRLAERPSNIAFAFKGMTKK*" /label="putB CDS" gene 326118..327029 /gene="putB" /locus_tag="BSU_03200" /old_locus_tag="BSU03200" /label="putB gene" CDS 327046..328593 /gene="putC" /locus_tag="BSU_03210" /old_locus_tag="BSU03210" /EC_number="1.2.1.88" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11418582, 17183215, 21840319, 22139509, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11418582, 17183215, 21840319, 22139509, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="1-pyrroline-5-carboxylate dehydrogenase" /protein_id="NP_388203.2" /db_xref="EnsemblGenomes-Gn:BSU03210" /db_xref="EnsemblGenomes-Tr:CAB12115" /db_xref="GOA:P94391" /db_xref="InterPro:IPR005932" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016160" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="SubtiList:BG12012" /db_xref="UniProtKB/Swiss-Prot:P94391" /translation="MTTPYKHEPFTNFQDQNNVEAFKKALATVSEYLGKDYPLVINGE RVETEAKIVSINPADKEEVVGRVSKASQEHAEQAIQAAAKAFEEWRYTSPEERAAVLF RAAAKVRRRKHEFSALLVKEAGKPWNEADADTAEAIDFMEYYARQMIELAKGKPVNSR EGEKNQYVYTPTGVTVVIPPWNFLFAIMAGTTVAPIVTGNTVVLKPASATPVIAAKFV EVLEESGLPKGVVNFVPGSGAEVGDYLVDHPKTSLITFTGSREVGTRIFERAAKVQPG QQHLKRVIAEMGGKDTVVVDEDADIELAAQSIFTSAFGFAGQKCSAGSRAVVHEKVYD QVLERVIEITESKVTAKPDSADVYMGPVIDQGSYDKIMSYIEIGKQEGRLVSGGTGDD SKGYFIKPTIFADLDPKARLMQEEIFGPVVAFCKVSDFDEALEVANNTEYGLTGAVIT NNRKHIERAKQEFHVGNLYFNRNCTGAIVGYHPFGGFKMSGTDSKAGGPDYLALHMQA KTISEMF*" /label="putC CDS" gene 327046..328593 /gene="putC" /locus_tag="BSU_03210" /old_locus_tag="BSU03210" /label="putC gene" promotor_-35 328017..328023 /Source="Nicolas_upshift_promotors" /id="U240" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.411588411588412" /psig="0.994005994005994" /xcortree=2488 /SigmaFactorBS="ggctttgcgggacaaaaatgctctgcaggttcACGTGCAgta gttcatgaaaAAGTGTATGATCAAGTATTAgagcgtgtcattgaaattacggaatcaa a" /listShort="S116, ycgO, S118, ycgP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 328037..328056 /Source="Nicolas_upshift_promotors" /id="U240" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.411588411588412" /psig="0.994005994005994" /xcortree=2488 /SigmaFactorBS="ggctttgcgggacaaaaatgctctgcaggttcACGTGCAgta gttcatgaaaAAGTGTATGATCAAGTATTAgagcgtgtcattgaaattacggaatcaa a" /listShort="S116, ycgO, S118, ycgP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 328045 /Source="Nicolas_upshifts" /id="U240" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.411588411588412" /psig="0.994005994005994" /xcortree=2488 /SigmaFactorBS="ggctttgcgggacaaaaatgctctgcaggttcACGTGCAgta gttcatgaaaAAGTGTATGATCAAGTATTAgagcgtgtcattgaaattacggaatcaa a" /listShort="S116, ycgO, S118, ycgP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 328128..328134 /Source="Nicolas_upshift_promotors" /id="U241" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.793206793206793" /psig=1 /xcortree=2403 /SigmaFactorBS="aaacctgacagtgcagatgtttatatgggaccTGTCATTgac caaggttctTATGATAAAATTATGAGCTAtattgagatcggaaaacaggaagggcgtt t" /listShort="S116, ycgO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 328147..328166 /Source="Nicolas_upshift_promotors" /id="U241" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.793206793206793" /psig=1 /xcortree=2403 /SigmaFactorBS="aaacctgacagtgcagatgtttatatgggaccTGTCATTgac caaggttctTATGATAAAATTATGAGCTAtattgagatcggaaaacaggaagggcgtt t" /listShort="S116, ycgO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 328156 /Source="Nicolas_upshifts" /id="U241" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.793206793206793" /psig=1 /xcortree=2403 /SigmaFactorBS="aaacctgacagtgcagatgtttatatgggaccTGTCATTgac caaggttctTATGATAAAATTATGAGCTAtattgagatcggaaaacaggaagggcgtt t" /listShort="S116, ycgO" /GFF_Attribute="listLong" /label="upshifts" misc_feature 328592..328596 /Source="Nicolas_upshift_promotors" /id="U242" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.315684315684316" /psig="0.248751248751249" /xcortree=3009 /SigmaFactorBS="cgggccggattacttggctctgcatatgcaagcaaaaacaat cagtgaaatgttctAAGCGggactaaatgggcatcctccctgcgggggtgtccatttc a" /listShort="S116, ycgO, S118, ycgP" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 328594..328716 /Source="Nicolas_S_feature" /locus_tag="new_347027_347149" /HighExp="S1, T2.0H, T2.30H, Lbstat, aero, HiOs, BC, Sw, LPh, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.52312199999999998" /TUshortSig="Sig-, SigA, SigA, SigA, SigEF" /TUshortPSig="0.249, 1, 0.994, 0.922, 0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S116" upshifts 328596 /Source="Nicolas_upshifts" /id="U242" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.315684315684316" /psig="0.248751248751249" /xcortree=3009 /SigmaFactorBS="cgggccggattacttggctctgcatatgcaagcaaaaacaat cagtgaaatgttctAAGCGggactaaatgggcatcctccctgcgggggtgtccatttc a" /listShort="S116, ycgO, S118, ycgP" /GFF_Attribute="listLong" /label="upshifts" CDS 328717..330138 /gene="putP" /locus_tag="BSU_03220" /old_locus_tag="BSU03220" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11902719, 14976255, 15849754, 16850406, 21840319, 22139509, 24142252" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11902719, 14976255, 15849754, 16850406, 21840319, 22139509, 24142252; Product type t: transporter" /codon_start=1 /transl_table=11 /product="proline permease" /protein_id="NP_388204.2" /db_xref="EnsemblGenomes-Gn:BSU03220" /db_xref="EnsemblGenomes-Tr:CAB12116" /db_xref="GOA:P94392" /db_xref="InterPro:IPR001734" /db_xref="InterPro:IPR011851" /db_xref="InterPro:IPR018212" /db_xref="SubtiList:BG12013" /db_xref="UniProtKB/Swiss-Prot:P94392" /translation="MLLIGYFAYKRTSNLTDYMLGGRSLGPAVTALSAGAADMSGWLL MGLPGAMFSTGLSGAWIVIGLCLGAWANWLYVAPRLRTYTEKAGNSITIPGFLENRFG DQTKLLRLFSGIVILVFFTFYVSSGMVSGGVLFNSILGMDYHTGLWIVTGVVVAYTLF GGFLAVSWTDFVQGIIMFAALILVPIVTFFHTGGAGDTVAEIRSVDPDMFNIFKGTSV LGIISLFAWGLGYFGQPHIIVRFMAITSVKEIKRARRIGMGWMILSAVGAVLTGLGGI AYYHQRGMTLKDPETIFIQLGNILFHPIITGFLISAILAAIMSTISSQLLVTSSSLVE DLYKSMFRRSASDKELVFLGRLAVLAVSIVALVLAWEKNNTILGLVSYAWAGFGASFG PVVLLSLFWKRMTKWGALAGMIVGAATVIIWANAGLSDFLYEMIPGFAASLLSVFFVS ILTQAPSQAVTDQFNDYQDTMSQ*" /label="putP CDS" gene 328717..330138 /gene="putP" /locus_tag="BSU_03220" /old_locus_tag="BSU03220" /label="putP gene" S_feature complement(329237..331092) /Source="Nicolas_S_feature" /locus_tag="new_347670_349525_c" /HighExp="T1.0H, T1.30H, T0.30H, T2.0H, T2.30H, T3.0H, T3.30H, C30, T4.0H, Lbstat" /AntisenseName="ycgP" /AntisenseCor="0.143781082577395" /AntisenseRegPval="-1.7" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig="0.679" /TUlongSig="NA" /TUlongPSig="NA" /label="S117" downshifts 330118 /Source="Nicolas_upshifts" /id="D142" /incds=0 /nref=21 /ntot=160 /MaxReadThrough="5.09597" /MaxDrop="4.17771" /score="5.89792272" /energy="-15.9" /TU="U239,U240,U242" /idTUdmin="U238" /TUdmin=4 /isTUend="TRUE" /label="downshifts" S_feature 330163..330259 /Source="Nicolas_S_feature" /locus_tag="new_348596_348692" /HighExp="S1, LPh, T2.0H, HPh, aero, Lbstat, LoTm, T2.30H, Cold, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, SigA" /TUshortPSig="0.249, 0.994, 0.922" /TUlongSig="NA" /TUlongPSig="NA" /label="S118" promotor_-35 330230..330237 /Source="Nicolas_upshift_promotors" /id="U243" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2392 /SigmaFactorBS="tttttcttttggaaacaaacgtattttttTCTATACAaaaag accccgtatGGATATGATTAAAGTAAAAAaagtataggagaaaaaggtatggaagagc t" /listShort="ycgP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 330252..330271 /Source="Nicolas_upshift_promotors" /id="U243" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2392 /SigmaFactorBS="tttttcttttggaaacaaacgtattttttTCTATACAaaaag accccgtatGGATATGATTAAAGTAAAAAaagtataggagaaaaaggtatggaagagc t" /listShort="ycgP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 330261 /Source="Nicolas_upshifts" /id="U243" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2392 /SigmaFactorBS="tttttcttttggaaacaaacgtattttttTCTATACAaaaag accccgtatGGATATGATTAAAGTAAAAAaagtataggagaaaaaggtatggaagagc t" /listShort="ycgP" /GFF_Attribute="listLong" /label="upshifts" CDS 330291..331526 /gene="putR" /locus_tag="BSU_03230" /old_locus_tag="BSU03230" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:21840319, 21964733, 22139509" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21840319, 21964733, 22139509; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional activator of proline degradationoperon" /protein_id="NP_388205.2" /db_xref="EnsemblGenomes-Gn:BSU03230" /db_xref="EnsemblGenomes-Tr:CAB12117" /db_xref="GOA:P94393" /db_xref="InterPro:IPR025736" /db_xref="InterPro:IPR029016" /db_xref="SubtiList:BG12014" /db_xref="UniProtKB/Swiss-Prot:P94393" /translation="MEELLERVFSFSDVDKLIDFISYELQKPVILESADFFLLAYNSY YINHFDSANQQTIFSKKCPVQIFERFLKDGIIEKLKTEPEPFRVNKIESIGLNQRVVV SAKHKGEVMGYIWIQELDQNLTDEELDFLYETSFHVGKIIYKTNKLKQEKEEKAEDLI KRAIYQQFTSEKELRREAERINTVLPSMFSVVILHAANGDGEAVEDLKENIRSYLNLR DKVSHVLTIESNIVIVVASFSQKSSVSSAASEFINKLLTHFHFQKIPTPIYIGIGNEY NHLLKLGKSYTEALEVIKAAEITGNQENIPYEYAKLGIYRYLESIEQKNEFLEYENKD LALLKAKDEESSTELLKTLEIYLLNNCKTKPAAEQLFIHQNTLNYRIKQITEMTSIDL SDFRTRCQLYLDLMLMKKK*" /label="putR CDS" gene 330291..331526 /gene="putR" /locus_tag="BSU_03230" /old_locus_tag="BSU03230" /label="putR gene" promotor_-10 complement(331085..331103) /Source="Nicolas_upshift_promotors" /id="U244" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.679320679320679" /psig="0.679320679320679" /xcortree=1717 /SigmaFactorBS="tcaagtgcttctgtgtagctcttgccaagttttaatagGTGA TTATattcgtttccgatACCGATATAAATAGGGGTAggtattttttgaaagtgaaaat g" /listShort="S117" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(331102) /Source="Nicolas_upshifts" /id="U244" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.679320679320679" /psig="0.679320679320679" /xcortree=1717 /SigmaFactorBS="tcaagtgcttctgtgtagctcttgccaagttttaatagGTGA TTATattcgtttccgatACCGATATAAATAGGGGTAggtattttttgaaagtgaaaat g" /listShort="S117" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(331117..331124) /Source="Nicolas_upshift_promotors" /id="U244" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.679320679320679" /psig="0.679320679320679" /xcortree=1717 /SigmaFactorBS="tcaagtgcttctgtgtagctcttgccaagttttaatagGTGA TTATattcgtttccgatACCGATATAAATAGGGGTAggtattttttgaaagtgaaaat g" /listShort="S117" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(331510) /Source="Nicolas_upshifts" /id="D143" /incds=0 /nref=1 /ntot=5 /MaxReadThrough="0.0291099999999993" /MaxDrop="3.08474" /score="-9.94728494" /energy="-16.9" /TU="NA" /idTUdmin="U245" /TUdmin=66 /isTUend="FALSE" /label="downshifts" CDS complement(331563..332420) /gene="ycgQ" /locus_tag="BSU_03240" /old_locus_tag="BSU03240" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388206.1" /db_xref="EnsemblGenomes-Gn:BSU03240" /db_xref="EnsemblGenomes-Tr:CAB12118" /db_xref="GOA:P94394" /db_xref="InterPro:IPR015402" /db_xref="SubtiList:BG12015" /db_xref="UniProtKB/Swiss-Prot:P94394" /translation="MFRLLVLMGFTFFFYHLHASGNLTKYINMKYAYLSFIAIFLLAI LTAVQAYLFIKSPEKSGHHHDHDCGCGHDHEHDHEQNKPFYQRYLIYVVFLFPLVSGI FFPIATLDSSIVKTKGFSFKAMESGDHYSQTQYLRPDASLYYAQDSYDKQMKQLFNKY SSKKEISLTDDDFLKGMETIYNYPGEFLGRTIEFHGFAYKGNAINKNQLFVLRFGIIH CIADSGVYGMLVEFPKDMDIKDDEWIHIKGTLASEYYQPFKSTLPVVKVTDWNTIKKP DDPYVYRGF*" /label="ycgQ CDS" gene complement(331563..332420) /gene="ycgQ" /locus_tag="BSU_03240" /old_locus_tag="BSU03240" /label="ycgQ gene" downshifts complement(331576) /Source="Nicolas_upshifts" /id="D144" /incds=0 /nref=48 /ntot=167 /MaxReadThrough="1.97725" /MaxDrop="4.53007" /score="-9.94728494" /energy="-16.9" /TU="NA" /idTUdmin="U245" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(332425..333309) /gene="ycgR" /locus_tag="BSU_03250" /old_locus_tag="BSU03250" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388207.1" /db_xref="EnsemblGenomes-Gn:BSU03250" /db_xref="EnsemblGenomes-Tr:CAB12119" /db_xref="GOA:P94395" /db_xref="InterPro:IPR005524" /db_xref="SubtiList:BG12016" /db_xref="UniProtKB/Swiss-Prot:P94395" /translation="MTAQSSFLQLNSIFISILIEAIPFILIGVILSGIIQMFVSEEMI ARIMPKNRFLAVLFGALAGVLFPACECGIIPITRRLLLKGVPLHAGVAFMLTAPIINP IVLFSTYIAFGNRWSVVFYRGGLALAVSLIIGVILSYQFKDNQLLKPDEPGHHHHHHG TLLQKLGGTLRHAIDEFFSVGKYLIIGAFIAAAMQTYVKTSTLLAIGQNDVSSSLVMM GLAFVLSLCSEVDAFIASSFSSTFSLGSLIAFLVFGAMVDIKNLLMMLAAFKKRFVFL LITYIVVIVLAGSLLVKG*" /label="ycgR CDS" gene complement(332425..333309) /gene="ycgR" /locus_tag="BSU_03250" /old_locus_tag="BSU03250" /label="ycgR gene" upshifts complement(333361) /Source="Nicolas_upshifts" /id="U245" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.566433566433566" /psig="0.566433566433566" /xcortree=2523 /SigmaFactorBS="tttggaatcctaaccaaagTGAAACGATcctttcccctcctc CGTCAAACAAGCAGtgcctttttttctggtatcataagaaaggcagcttaacatgagc g" /listShort="ycgR, ycgQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(333366..333379) /Source="Nicolas_upshift_promotors" /id="U245" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.566433566433566" /psig="0.566433566433566" /xcortree=2523 /SigmaFactorBS="tttggaatcctaaccaaagTGAAACGATcctttcccctcctc CGTCAAACAAGCAGtgcctttttttctggtatcataagaaaggcagcttaacatgagc g" /listShort="ycgR, ycgQ" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(333394..333402) /Source="Nicolas_upshift_promotors" /id="U245" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.566433566433566" /psig="0.566433566433566" /xcortree=2523 /SigmaFactorBS="tttggaatcctaaccaaagTGAAACGATcctttcccctcctc CGTCAAACAAGCAGtgcctttttttctggtatcataagaaaggcagcttaacatgagc g" /listShort="ycgR, ycgQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(333409..334263) /gene="ycgS" /locus_tag="BSU_03260" /old_locus_tag="BSU03260" /EC_number="3.7.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aromatic hydrocarbon hydrolase" /protein_id="NP_388208.1" /db_xref="EnsemblGenomes-Gn:BSU03260" /db_xref="EnsemblGenomes-Tr:CAB12120" /db_xref="GOA:P94396" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12017" /db_xref="UniProtKB/Swiss-Prot:P94396" /translation="MKRRVETITFDGGTLEYSVTGKGTPILVMHGGHSNCYEEFGYTA LIEQGYSIITPSRPGYGRTSKEIGKSLANACRFYVKLLDHLQIESVHVIAISAGGPSG ICFASHYPERVNTLTLQSAVTKEWLTPKDTEYKLGEILFRPPVEKWIWKLISSLNNAF PRLMFRAMSPQFSTLPFQRIKSLMNEKDIEAFRKMNSRQRSGEGFLIDLSQTAAVSLK DLQAIICPVLIMQSVYDGLVDLSHAHHAKEHIRGAVLCLLHSWGHLIWLGKEAAETGS ILLGFLES*" /label="ycgS CDS" gene complement(333409..334263) /gene="ycgS" /locus_tag="BSU_03260" /old_locus_tag="BSU03260" /label="ycgS gene" promotor_-10 complement(334282..334301) /Source="Nicolas_upshift_promotors" /id="U246" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.715284715284715" /psig=1 /xcortree=1859 /SigmaFactorBS="gtatatcatatttcaagggcctttgtttattcatttcttcta cCTTGtggtcaattgctgaAAACTCTATAATAGGCAAAAaccaattgggtgaaacaga t" /listShort="ycgS, ycgR" /listLong="ycgQ" /label="promotor_-10" upshifts complement(334302) /Source="Nicolas_upshifts" /id="U246" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.715284715284715" /psig=1 /xcortree=1859 /SigmaFactorBS="gtatatcatatttcaagggcctttgtttattcatttcttcta cCTTGtggtcaattgctgaAAACTCTATAATAGGCAAAAaccaattgggtgaaacaga t" /listShort="ycgS, ycgR" /listLong="ycgQ" /label="upshifts" promotor_-35 complement(334316..334319) /Source="Nicolas_upshift_promotors" /id="U246" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.715284715284715" /psig=1 /xcortree=1859 /SigmaFactorBS="gtatatcatatttcaagggcctttgtttattcatttcttcta cCTTGtggtcaattgctgaAAACTCTATAATAGGCAAAAaccaattgggtgaaacaga t" /listShort="ycgS, ycgR" /listLong="ycgQ" /label="promotor_-35" misc_feature 334353..334372 /Source="Nicolas_upshift_promotors" /id="U247" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig="0.993006993006993" /xcortree=2116 /SigmaFactorBS="ttcagcaattgaccacaaggtagaagaaatgaataaacaaag gcccttgaaaTATGATATACTTTGTATTGAtattcattctcaattaaaactttgatat a" /listShort="S119, ycgT, S120" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(334353..334371) /Source="Nicolas_upshift_promotors" /id="U248" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=774 /SigmaFactorBS="agccatccgtcctgcctcccgttcacatctatatcaaaGTTT TAattgagaatgaatatCAATACAAAGTATATCATAtttcaagggcctttgtttattc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 334360..334424 /Source="Nicolas_S_feature" /locus_tag="new_352793_352857" /HighExp="B60, Lbexp, LBGexp, dia0, B36, HiOs, GM 15, GM 10, Salt, dia5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S119" upshifts 334361 /Source="Nicolas_upshifts" /id="U247" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig="0.993006993006993" /xcortree=2116 /SigmaFactorBS="ttcagcaattgaccacaaggtagaagaaatgaataaacaaag gcccttgaaaTATGATATACTTTGTATTGAtattcattctcaattaaaactttgatat a" /listShort="S119, ycgT, S120" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(334370) /Source="Nicolas_upshifts" /id="U248" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=774 /SigmaFactorBS="agccatccgtcctgcctcccgttcacatctatatcaaaGTTT TAattgagaatgaatatCAATACAAAGTATATCATAtttcaagggcctttgtttattc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(334387..334392) /Source="Nicolas_upshift_promotors" /id="U248" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=774 /SigmaFactorBS="agccatccgtcctgcctcccgttcacatctatatcaaaGTTT TAattgagaatgaatatCAATACAAAGTATATCATAtttcaagggcctttgtttattc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 334425..335435 /gene="ffoR" /locus_tag="BSU_03270" /old_locus_tag="BSU03270" /EC_number="1.18.1.-" /EC_number="1.8.1.-" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16672620, 25826316" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16672620, 25826316; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="Fur-regulated NADPH:ferredoxin oxidoreductase" /protein_id="NP_388209.1" /db_xref="EnsemblGenomes-Gn:BSU03270" /db_xref="EnsemblGenomes-Tr:CAB12121" /db_xref="GOA:O31475" /db_xref="InterPro:IPR000103" /db_xref="InterPro:IPR022890" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG12018" /db_xref="UniProtKB/Swiss-Prot:O31475" /translation="MAENQEVYDVTIIGGGPIGLFTAFYCGMRELKTKVIEFLPKLGG KVSLFFPEKIIRDIGGIPGIAGKQLIEQLKEQAATFDPDIVLNQRVTGFERLDDGTIV LTGSEGKKHYTRTVILACGMGTLEVNEFDSEDAARYAGKNLHYGVEKLDAFKGKRVVI SGGGDTAVDWANELEPIAASVTVVHRREEFGGMESSVTKMKQSSVRVLTPYRLEQLNG DEEGIKSVTVCHTESGQRKDIEIDELIINHGFKIDLGPMMEWGLEIEEGRVKADRHMR TNLPGVFVAGDAAFYESKLRLIAGGFTEGPTAVNSAKAYLDPKAENMAMYSTHHKKLV HK*" /label="ffoR CDS" gene 334425..335435 /gene="ffoR" /locus_tag="BSU_03270" /old_locus_tag="BSU03270" /label="ffoR gene" S_feature 335436..337883 /Source="Nicolas_S_feature" /locus_tag="new_353869_356316" /HighExp="B60, Lbexp, GM 10, GM 25, HiOs, GM 15, dia0, GM 45, LBGexp, H2O2" /AntisenseName="nasF" /AntisenseCor="-0.30348565853404702" /AntisenseRegPval="-6.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S120" CDS complement(335467..336918) /gene="nasF" /locus_tag="BSU_03280" /old_locus_tag="BSU03280" /EC_number="2.1.1.107" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9765565, 10217486, 15028686" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9765565, 10217486, 15028686; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="uroporphyrin-III C-methyltransferase" /protein_id="NP_388210.1" /db_xref="EnsemblGenomes-Gn:BSU03280" /db_xref="EnsemblGenomes-Tr:CAB12122" /db_xref="GOA:P42437" /db_xref="InterPro:IPR000878" /db_xref="InterPro:IPR003043" /db_xref="InterPro:IPR006366" /db_xref="InterPro:IPR012409" /db_xref="InterPro:IPR014776" /db_xref="InterPro:IPR014777" /db_xref="InterPro:IPR035996" /db_xref="InterPro:IPR036108" /db_xref="SubtiList:BG11098" /db_xref="UniProtKB/Swiss-Prot:P42437" /translation="MIMKNGIVYFVGAGPGDPGLLTIKGKQALKEADVILYDRLANPK LLEFASPDCQFIYCGKLPNRHFMKQKEINALLVEKALNGLTVVRLKGGDPSVFGRVGE EADALHEHGIRYEMVPGITSGIAAPLYAGIPVTHRDFASSFAMITAHDKSLKGTPNLD WEGLARSVQTLVFYMGVKNLSYICQQLISYGKSPSVPVIVIQWGTWGRQRSVKGTLEN IQQKVQEHQITNPAIIVIGDIVNFQTHSWFESKPLIGRHLMVVTHGEDEDPLADKLRD SGADLIEWPKWRTENMPVNEEILRKIGTFEDVFFTSRRAVCEFFRALASQKIDIRQLT AKLSAASEQAKTELEKRGFLVTAIQPDSEKRLVVGSRHAVENMQKHESCSFYITHENV IDDRFTHMIQRTISESPLHMVICPNKLSVQQLINGGEQIGILPEPSASRPPIVCIGDD SAAGIYGFTAVQEQDELLAFIHNQHAEKKLLHT*" /label="nasF CDS" gene complement(335467..336918) /gene="nasF" /locus_tag="BSU_03280" /old_locus_tag="BSU03280" /label="nasF gene" downshifts complement(335471) /Source="Nicolas_upshifts" /id="D145" /incds=0 /nref=131 /ntot=230 /MaxReadThrough="1.40657" /MaxDrop="6.58881" /score="10.9556399" /energy="-11.7" /TU="NA" /idTUdmin="U250" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(336979..337299) /gene="nasE" /locus_tag="BSU_03290" /old_locus_tag="BSU03290" /EC_number="1.7.1.4" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10217486, 15028686, 9765565, 22103536" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10217486, 15028686, 9765565, 22103536; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="assimilatory nitrite reductase subunit" /protein_id="NP_388211.1" /db_xref="EnsemblGenomes-Gn:BSU03290" /db_xref="EnsemblGenomes-Tr:CAB12123" /db_xref="GOA:P42436" /db_xref="InterPro:IPR012748" /db_xref="InterPro:IPR017941" /db_xref="InterPro:IPR036922" /db_xref="SubtiList:BG11097" /db_xref="UniProtKB/Swiss-Prot:P42436" /translation="MVNKDVTKVCIGKIEELPEQLGKTVYIEDKELAVFKLSDGSIRA IENRCPHKGGVLAEGIVSGQYVFCPMHDWKISLEDGIVQEPDHGCVKTYETLIEGEHV YLVY*" /label="nasE CDS" gene complement(336979..337299) /gene="nasE" /locus_tag="BSU_03290" /old_locus_tag="BSU03290" /label="nasE gene" promotor_-35 337150..337155 /Source="Nicolas_upshift_promotors" /id="U249" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.00899100899100899" /xcortree=84 /SigmaFactorBS="tgacgatgccttctgccaggacgccgcccttatgCGGACAgc ggttttcaatgGCGCGgatgcttccgtctgaaagcttgaaaaccgcgagctccttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 337169..337173 /Source="Nicolas_upshift_promotors" /id="U249" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.00899100899100899" /xcortree=84 /SigmaFactorBS="tgacgatgccttctgccaggacgccgcccttatgCGGACAgc ggttttcaatgGCGCGgatgcttccgtctgaaagcttgaaaaccgcgagctccttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 337176 /Source="Nicolas_upshifts" /id="U249" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.00899100899100899" /xcortree=84 /SigmaFactorBS="tgacgatgccttctgccaggacgccgcccttatgCGGACAgc ggttttcaatgGCGCGgatgcttccgtctgaaagcttgaaaaccgcgagctccttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(337208) /Source="Nicolas_upshifts" /id="U250" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.853146853146853" /psig="0.957042957042957" /xcortree=1590 /SigmaFactorBS="tcggaaaaattgaagaatTGCCTGAAcaattaggcaaaaCAG TGTATATTGAAGATAAGgagctcgcggttttcaagctttcagacggaagcatccgcgc c" /listShort="nasF" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(337210..337229) /Source="Nicolas_upshift_promotors" /id="U250" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.853146853146853" /psig="0.957042957042957" /xcortree=1590 /SigmaFactorBS="tcggaaaaattgaagaatTGCCTGAAcaattaggcaaaaCAG TGTATATTGAAGATAAGgagctcgcggttttcaagctttcagacggaagcatccgcgc c" /listShort="nasF" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(337243..337250) /Source="Nicolas_upshift_promotors" /id="U250" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.853146853146853" /psig="0.957042957042957" /xcortree=1590 /SigmaFactorBS="tcggaaaaattgaagaatTGCCTGAAcaattaggcaaaaCAG TGTATATTGAAGATAAGgagctcgcggttttcaagctttcagacggaagcatccgcgc c" /listShort="nasF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(337331..339748) /gene="nasD" /locus_tag="BSU_03300" /old_locus_tag="BSU03300" /EC_number="1.7.1.4" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10972836, 15028686, 9765565, 16428414, 22103536" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10972836, 15028686, 9765565, 16428414, 22103536; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="assimilatory nitrite reductase subunit" /protein_id="NP_388212.1" /db_xref="EnsemblGenomes-Gn:BSU03300" /db_xref="EnsemblGenomes-Tr:CAB12124" /db_xref="GOA:P42435" /db_xref="InterPro:IPR005117" /db_xref="InterPro:IPR006066" /db_xref="InterPro:IPR006067" /db_xref="InterPro:IPR007419" /db_xref="InterPro:IPR012744" /db_xref="InterPro:IPR017121" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036136" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG11096" /db_xref="UniProtKB/Swiss-Prot:P42435" /translation="MGKKQLVLVGNGMAGVRAIEEILSVAKDEFQITIFGAEPHPNYN RILLSKVLQGDTDIKDITLNDWDWYEENNIQLYTNETVIKVDTENKTVITDADRIQPY DELILATGSVPFILPIPGADKKGVTAFRDIKDTDTMLAASKQYKKAAVIGGGLLGLEA ARGLLNLGMDVSVIHLAPFLMERQLDATAGRLLQNELEKQGMTFLLEKQTEEIVGDDR VEGLRFKDGTSIEADLVVMAVGIRPNTTLGAESGIPVNRGIIVNDYMQTEIPHIYAVG ECAEHRGIAYGLVAPLYEQAKVLAKHMCGIETKPYEGSVLSTQLKVSGVEVFSAGDFN ESEEKKAIKVFDEQDGIYKKIVLRGNQIVGAVLFGDSSEGNRLFSMIQKEADISETSK ISILQPLSQEAGTSITAAMSDDEIICGCNGVSKGAIIQAIQEKGCSSTDEIKACTGAS RSCGGCKPLVEEILQHTLGSDFDASAQKEAICGCTTLSRDEVVEEIKAKGLSHTREVM NVLGWKTPEGCSKCRPALNYYLGMINPTKYEDDRTSRFVNERMHANIQKDGTYSVVPR MYGGVTNSTDLRKIADVVDKYEIPLVKMTGGQRIDLIGVKKEDLPKVWEDLDMPSGYA YGKTLRTVKTCVGEQFCRFGTQDSMALGIALEKKFEGLNTPHKVKMAVSACPRNCAES GIKDLGVVGIDGGWELYVGGNGGTHLRAGDLLMKVKTNEEVLEYAGAYLQYYRETANY LERTSAWLERVGLSHVQSVLNDPEKRQELNGRMNETLSVHKDPWKDFLEDKQTSKELF ENVVTTS*" /label="nasD CDS" gene complement(337331..339748) /gene="nasD" /locus_tag="BSU_03300" /old_locus_tag="BSU03300" /label="nasD gene" promotor_-10 complement(339773..339792) /Source="Nicolas_upshift_promotors" /id="U251" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.915084915084915" /psig="0.998001998001998" /xcortree=1620 /SigmaFactorBS="cttttcgtatattttgttacattttataacatgtatcTTAAA TAttcctttttgcTGTGCTACGCTGGAAAAAACatttgataaggagcggatcatctga t" /listShort="nasD, nasE, nasF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(339787) /Source="Nicolas_upshifts" /id="U251" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.915084915084915" /psig="0.998001998001998" /xcortree=1620 /SigmaFactorBS="cttttcgtatattttgttacattttataacatgtatcTTAAA TAttcctttttgcTGTGCTACGCTGGAAAAAACatttgataaggagcggatcatctga t" /listShort="nasD, nasE, nasF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(339804..339810) /Source="Nicolas_upshift_promotors" /id="U251" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.915084915084915" /psig="0.998001998001998" /xcortree=1620 /SigmaFactorBS="cttttcgtatattttgttacattttataacatgtatcTTAAA TAttcctttttgcTGTGCTACGCTGGAAAAAACatttgataaggagcggatcatctga t" /listShort="nasD, nasE, nasF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(339870..342002) /gene="nasC" /locus_tag="BSU_03310" /old_locus_tag="BSU03310" /EC_number="1.7.99.4" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10972836, 15028686, 9765565" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10972836, 15028686, 9765565; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="assimilatory nitrate reductase (catalytic subunit)" /protein_id="NP_388213.2" /db_xref="EnsemblGenomes-Gn:BSU03310" /db_xref="EnsemblGenomes-Tr:CAB12125" /db_xref="GOA:P42434" /db_xref="InterPro:IPR006655" /db_xref="InterPro:IPR006656" /db_xref="InterPro:IPR006657" /db_xref="InterPro:IPR006963" /db_xref="InterPro:IPR009010" /db_xref="InterPro:IPR027467" /db_xref="SubtiList:BG11095" /db_xref="UniProtKB/Swiss-Prot:P42434" /translation="MTERLLRYFRDKQQDVQSEKTYDTQCPFCSMQCKMQLVEQTIVT RKKYTAIGIDNPTTQGRLCIKGMNAHQHALNSSRITRPLLKKNGEFMPVSWEEALNHI KDQVTMIQTEHGHDAMAVYGSASITNEEAYLLGKFARVGLQTKYIDYNGRLCMSAAAT AANQTFGADRGLTNPLSDIPHTRVIILAGTNIAECQPTIMPYFEKAKENGAYFIAIDP RETATTKIADLHLKIKPGTDAALANGLVKIIIDEQLINEDFIQSRTNGFEELKQHTDS LDLNDIAEQTSVSLVDIRKAAVKFAKETSGMLFTARGIEQQTDGTAAVKGFLNMVLIT GKIGKPYSGYGAITGQGNGQGAREHGQKADQLPGYRSIENEEHRAHIAKVWGIHQDEL PRKGVSAYEMMEKINDGDIKGLFLMCSNPAVSSPNANLVKKALRRLTFFVAIDLFISE TAKYADVILPASSYLEDEGTMTNVEGRVTLREASRPCPGEAKHDWQIICDLASALGKG RYFSYTSAEDIFNELREASRGGIADYSGISYGRLRREGGIHWPCPESDHPGTGRLFTE SFAHPDQKAALSVIPNEPPVPKEKPTADYPLYLTTGRVMSHYLTGVQTRKSAALAARH FESFMEIHPQTAATYNIEDRVLVKIESPRGSITVRSKLSEQIRKDTVFVPIHWADAQN VNDLIGEALDPACKMPGFKVCAVRIIPI*" /label="nasC CDS" gene complement(339870..342002) /gene="nasC" /locus_tag="BSU_03310" /old_locus_tag="BSU03310" /label="nasC gene" CDS complement(342009..344324) /gene="nasB" /locus_tag="BSU_03320" /old_locus_tag="BSU03320" /EC_number="1.7.1.3" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7836289, 8799114, 9765565, 10940050, 10972836, 15028686, 24122235" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7836289, 8799114, 9765565, 10940050, 10972836, 15028686, 24122235; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="assimilatory nitrate reductase (electron transfer subunit NasB)" /protein_id="NP_388214.2" /db_xref="EnsemblGenomes-Gn:BSU03320" /db_xref="EnsemblGenomes-Tr:CAB12126" /db_xref="GOA:P42433" /db_xref="InterPro:IPR005117" /db_xref="InterPro:IPR007419" /db_xref="InterPro:IPR012744" /db_xref="InterPro:IPR017121" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036136" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG11094" /db_xref="UniProtKB/Swiss-Prot:P42433" /translation="MKKQRLVLAGNGMAGIRCIEEVLKLNRHMFEIVIFGSEPHPNYN RILLSSVLQGEASLDDITLNSKDWYDKHGITLYTGETVIQIDTDQQQVITDRKRTLSY DKLIVATGSSPHILPIPGADKKGVYGFRTIEDCQALMNMAQHFQKAAVIGAGLLGLEA AVGLQHLGMDVSVIHHSAGIMQKQLDQTAARLLQTELEQKGLTFLLEKDTVSISGATK ADRIHFKDGSSLKADLIVMAAGVKPNIELAVSAGIKVNRGIIVNDFMQTSEPNIYAVG ECAEHNGTVYGLVAPLYEQGKALASHICGVPCEEYQGSAPSAALKIAGIDVWSAGKIQ EDERTTSIKIYDEQAGVYKKALFVDDKLAGVILFGDTRDKQRLLDSLLKQRDISIAKK QIIEPETSGPLFESMPSSETICQCNTVTKGAIEDAVHTNSLTTVEEVKHCTKATGSCG GCKPLVEDLLRYMTNSEYTKPASTPSFCSCTDFTEDDIIAELQRRPFTNPAEVMNQLD WKTKNGCSTCVPAIQYYLEMLYPGFVQPEPATEETCILIPQMYGGRTNAEQLRTIANI IEAYSIPDVSITHGQRLKLSGIKPADLPNMKKDLKMPVYTNEHRHALQSIKACTCGQN RSIQQLAAQIERQLEMLPLPAPISISLSCETDCTEAALQDVGAIRTQAGWDIHIGGVR GTHARSGALFCVTENEDSTAGMIKGLIQYYRETAHYLEGVHQWIDRLGIVHIREVLFE EDLRAQLLESLQTDLSLIQNPTVETGAYKKG*" /label="nasB CDS" gene complement(342009..344324) /gene="nasB" /locus_tag="BSU_03320" /old_locus_tag="BSU03320" /label="nasB gene" promotor_no_box complement(344343..344443) /Source="Nicolas_upshift_promotors" /id="U252" /multdbtbs="SigA" /comp="M21" /sig="Sig-" /pcomp="0.241758241758242" /psig="0.410589410589411" /xcortree=313 /SigmaFactorBS="ttattttctggaaaagacatgtgtaagtttttgtgacacgtt taatgcgttaacaatgcattgtgacataatttttaataggagaaaacttacgagcttc g" /listShort="nasB, nasC, nasD, nasE, nasF" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(344383) /Source="Nicolas_upshifts" /id="U252" /multdbtbs="SigA" /comp="M21" /sig="Sig-" /pcomp="0.241758241758242" /psig="0.410589410589411" /xcortree=313 /SigmaFactorBS="ttattttctggaaaagacatgtgtaagtttttgtgacacgtt taatgcgttaacaatgcattgtgacataatttttaataggagaaaacttacgagcttc g" /listShort="nasB, nasC, nasD, nasE, nasF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 344426..344433 /Source="Nicolas_upshift_promotors" /id="U253" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.613386613386613" /psig="0.928071928071928" /xcortree=319 /SigmaFactorBS="ttaaacgtgtcacaaaaacttacacatGTCTTTTCcagaaaa taatggTCCTATATCCTTGATTCAGAaaatgtaaaataatgagggtctagaaagggga a" /listShort="nasA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 344447..344466 /Source="Nicolas_upshift_promotors" /id="U253" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.613386613386613" /psig="0.928071928071928" /xcortree=319 /SigmaFactorBS="ttaaacgtgtcacaaaaacttacacatGTCTTTTCcagaaaa taatggTCCTATATCCTTGATTCAGAaaatgtaaaataatgagggtctagaaagggga a" /listShort="nasA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 344459 /Source="Nicolas_upshifts" /id="U253" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.613386613386613" /psig="0.928071928071928" /xcortree=319 /SigmaFactorBS="ttaaacgtgtcacaaaaacttacacatGTCTTTTCcagaaaa taatggTCCTATATCCTTGATTCAGAaaatgtaaaataatgagggtctagaaagggga a" /listShort="nasA" /GFF_Attribute="listLong" /label="upshifts" CDS 344504..345709 /gene="nasA" /locus_tag="BSU_03330" /old_locus_tag="BSU03330" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7868621, 12823818, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative nitrate transporter" /protein_id="NP_388215.2" /db_xref="EnsemblGenomes-Gn:BSU03330" /db_xref="EnsemblGenomes-Tr:CAB12127" /db_xref="GOA:P42432" /db_xref="InterPro:IPR004737" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11093" /db_xref="UniProtKB/Swiss-Prot:P42432" /translation="MKLSELKTSGHPLTLLCSFLYFDVSFMIWVMLGALGVYISQDFG LSPFEKGLVVAVPILSGSVFRIILGILTDRIGPKKTAVIGMLVTMIPLLWGTFGGRSL TELYAIGILLGVAGASFAVALPMASRWYPPHLQGLAMGIAGAGNSGTLFATLFGPRLA EQFGWHIVMGIALIPLLIVFILFVSMAKDSPAQPSPQPLKSYLHVFGQKETWFFCLLY SVTFGGFVGLSSFLSIFFVDQYQLSKIHAGDFVTLCVAAGSFFRPVGGLISDRVGGTK VLSVLFVIVALCMAGVSSLPSLSMVIVLLFVGMMGLGMGNGAVFQLVPQRFRKEIGMV TGIVGAAGGIGGFFLPNILGSLKQMTGTYAIGFITFSCIALLAFALVLAAGYYWRKSW SAESSPADV*" /label="nasA CDS" gene 344504..345709 /gene="nasA" /locus_tag="BSU_03330" /old_locus_tag="BSU03330" /label="nasA gene" downshifts 345694 /Source="Nicolas_upshifts" /id="D146" /incds=0 /nref=1 /ntot=3 /MaxReadThrough="2.02479" /MaxDrop="3.6823" /score="39.2612286" /energy="-11.9" /TU="NA" /idTUdmin="U253" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 345753..345759 /Source="Nicolas_upshift_promotors" /id="U254" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.362637362637363" /psig="0.998001998001998" /xcortree=667 /SigmaFactorBS="cacgcgtttgtgcgtgtcttttttattttctCTTGATTttca acagtgaaccGATCAAAATAAATAGTAATTattacgatttgttagtgagaggagtttt c" /listShort="folEB, yciB" /listLong="yczL, yciC" /label="promotor_-35" promotor_-10 345774..345793 /Source="Nicolas_upshift_promotors" /id="U254" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.362637362637363" /psig="0.998001998001998" /xcortree=667 /SigmaFactorBS="cacgcgtttgtgcgtgtcttttttattttctCTTGATTttca acagtgaaccGATCAAAATAAATAGTAATTattacgatttgttagtgagaggagtttt c" /listShort="folEB, yciB" /listLong="yczL, yciC" /label="promotor_-10" upshifts 345782 /Source="Nicolas_upshifts" /id="U254" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.362637362637363" /psig="0.998001998001998" /xcortree=667 /SigmaFactorBS="cacgcgtttgtgcgtgtcttttttattttctCTTGATTttca acagtgaaccGATCAAAATAAATAGTAATTattacgatttgttagtgagaggagtttt c" /listShort="folEB, yciB" /listLong="yczL, yciC" /label="upshifts" CDS 345826..346740 /gene="folEB" /locus_tag="BSU_03340" /old_locus_tag="BSU03340" /EC_number="3.5.4.16" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12426338, 17032654, 19767425" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12426338, 17032654, 19767425; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="GTP cyclohydrolase I" /protein_id="NP_388216.2" /db_xref="EnsemblGenomes-Gn:BSU03340" /db_xref="EnsemblGenomes-Tr:CAB12128" /db_xref="GOA:P94398" /db_xref="InterPro:IPR003801" /db_xref="InterPro:IPR022838" /db_xref="SubtiList:BG12019" /db_xref="UniProtKB/Swiss-Prot:P94398" /translation="MNQHTLLPKKTERLQYFGSVSPIKGEKPVEKEKMKDLQNIRKDY FFDIQHVGVANVSHPVTITSAMMPAEQTTAANFTMTCNLPRNQKGINMSRLTELLQVY HQNGWILSFSSLQQFTKELAENMDTSSATVEVRFPWFFERKSPKLEKAGLMHADIFMS VTYRKDQPFKQRAGISAKVTTLCPCSKEISEYSAHNQRGTVSIWADIHPAASLPSDVK ADLLHAAESNASARLHPVLKRPDEKAVTETAYENPRFVEDLARLIAADLFELEWVSAF EIECRNEESIHLHDAYAKLCFSKEVDKI*" /label="folEB CDS" gene 345826..346740 /gene="folEB" /locus_tag="BSU_03340" /old_locus_tag="BSU03340" /label="folEB gene" CDS 346737..347321 /gene="yciB" /locus_tag="BSU_03350" /old_locus_tag="BSU03350" /function="16.1: Circulate" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12426338, 20013255; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative Zn(2+)-dependent division lipoprotein (schizosome)" /protein_id="NP_388217.2" /db_xref="EnsemblGenomes-Gn:BSU03350" /db_xref="EnsemblGenomes-Tr:CAB12129" /db_xref="GOA:C0SP99" /db_xref="InterPro:IPR005490" /db_xref="SubtiList:BG12020" /db_xref="UniProtKB/Swiss-Prot:C0SP99" /translation="MKLSLFIIAVLMPVILLSACSDHAEEHASINTKKTVENITDVRK TAKTSIDWTKPSGGEYPDIKQKHVWIDVNVKEQKAYIKEGSNTIYTMMISSGLDQTKD DATPKGTFYVEPERGEWFFSEGYQEGAEYWVSWKNHGEFLFHSVPMTKDQKVIKTEAE KLGTKASHGCIRLTIPDAKWVYENIPEHTKVVIS*" /label="yciB CDS" gene 346737..347321 /gene="yciB" /locus_tag="BSU_03350" /old_locus_tag="BSU03350" /label="yciB gene" promotor_-35 347332..347339 /Source="Nicolas_upshift_promotors" /id="U255" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.671328671328671" /psig=1 /xcortree=668 /SigmaFactorBS="aaaagtggtgatcagctgaattgaaaaccGTTGACAAaaagg aaaaaagaCCATACAATTTAAATCGTAAcaattacgttttatgataaatggcttatca t" /listShort="yczL, yciC, S121" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 347353..347372 /Source="Nicolas_upshift_promotors" /id="U255" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.671328671328671" /psig=1 /xcortree=668 /SigmaFactorBS="aaaagtggtgatcagctgaattgaaaaccGTTGACAAaaagg aaaaaagaCCATACAATTTAAATCGTAAcaattacgttttatgataaatggcttatca t" /listShort="yczL, yciC, S121" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 347363 /Source="Nicolas_upshifts" /id="U255" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.671328671328671" /psig=1 /xcortree=668 /SigmaFactorBS="aaaagtggtgatcagctgaattgaaaaccGTTGACAAaaagg aaaaaagaCCATACAATTTAAATCGTAAcaattacgttttatgataaatggcttatca t" /listShort="yczL, yciC, S121" /GFF_Attribute="listLong" /label="upshifts" CDS 347417..347602 /gene="yczL" /locus_tag="BSU_03359" /old_locus_tag="BSU03359" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097674.1" /db_xref="EnsemblGenomes-Gn:BSU03359" /db_xref="EnsemblGenomes-Tr:CAX52544" /db_xref="UniProtKB/Swiss-Prot:C0H3U7" /translation="MKSGKASIKDLAVGKGKDLRWGKGLNAVGVFTDLEIGRQREMSA KSCSTPLYIRRSIQFKS*" /label="yczL CDS" gene 347417..347602 /gene="yczL" /locus_tag="BSU_03359" /old_locus_tag="BSU03359" /label="yczL gene" CDS 347630..348823 /gene="zinU" /locus_tag="BSU_03360" /old_locus_tag="BSU03360" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:2013568, 9811636, 12426338, 18344368, 19648245, 27060116, 27561249" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2013568, 9811636, 12426338, 18344368, 19648245, 27060116, 27561249; Product type t: transporter" /codon_start=1 /transl_table=11 /product="zinc metallochaperone with NTPase activity" /protein_id="NP_388218.1" /db_xref="EnsemblGenomes-Gn:BSU03360" /db_xref="EnsemblGenomes-Tr:CAB12130" /db_xref="GOA:P94400" /db_xref="InterPro:IPR003495" /db_xref="InterPro:IPR011629" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036627" /db_xref="SubtiList:BG12021" /db_xref="UniProtKB/Swiss-Prot:P94400" /translation="MKKIPVTVLSGYLGAGKTTLLNSILQNREGLKIAVIVNDMSEVN IDAGLVKQEGGLSRTDEKLVEMSNGCICCTLREDLLIEVEKLAKDGRFDYIVIESTGI SEPIPVAQTFSYIDEEMGIDLTKFCQLDTMVTVVDANRFWHDYQSGESLLDRKEALGE KDEREIADLLIDQIEFCDVLILNKCDLVSEQELEQLENVLRKLQPRARFIRSVKGNVK PQEILHTGLFNFEEASGSAGWIQELTAGHAEHTPETEEYGISSFVYKRRLPFHSTRFY RWLDQMPKNVVRAKGIVWCASHNNLALLMSQAGPSVTIEPVSYWVAALPKLEQEQVKQ QEPEILEEWDPEFGDRLTQLVFIGTDLDEETITKELDQCLLTEYEFDSDWSLFEDPFK WKLNQ*" /label="zinU CDS" gene 347630..348823 /gene="zinU" /locus_tag="BSU_03360" /old_locus_tag="BSU03360" /label="zinU gene" downshifts 348815 /Source="Nicolas_upshifts" /id="D147" /incds=0 /nref=26 /ntot=45 /MaxReadThrough="5.12378" /MaxDrop="5.8275" /score="15.6427627" /energy="-9.2" /TU="U255" /idTUdmin="U255" /TUdmin="-792" /isTUend="FALSE" /label="downshifts" S_feature 348860..350529 /Source="Nicolas_S_feature" /locus_tag="new_367293_368962" /HighExp="Etha, B60, Cold, Heat, B36, C30, BMM, S6, C90, S2" /AntisenseName="yckB" /AntisenseCor="-0.170121935628575" /AntisenseRegPval="-2.2999999999999998" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S121" CDS complement(348872..349552) /gene="yckA" /locus_tag="BSU_03370" /old_locus_tag="BSU03370" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15849754, 16850406, 23038252; Product type t: transporter" /codon_start=1 /transl_table=11 /product="aminoacid ABC transporter (permease subunit)" /protein_id="NP_388219.1" /db_xref="EnsemblGenomes-Gn:BSU03370" /db_xref="EnsemblGenomes-Tr:CAB12131" /db_xref="GOA:P42399" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR010065" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11177" /db_xref="UniProtKB/Swiss-Prot:P42399" /translation="MINSIQWEYIFNTKLAIESFPYVIKGIGYTLLISFVSMFAGTVI GLFISLARMSKLALLRWPAKLYISFMRGVPILVILFILYFGFPYIGIEFSAVTAALIG FSLNSAAYIAEINRSAISSVEKGQWEAASSLGLSYWQTMRGIILPQSIRIALPPLANV LLDLIKASSLAAMITVPELLQHAKIIGGREFDYMTMYILTALIYWAICSIAAVFQNIL EKKYAHYV*" /label="yckA CDS" gene complement(348872..349552) /gene="yckA" /locus_tag="BSU_03370" /old_locus_tag="BSU03370" /label="yckA gene" downshifts complement(348878) /Source="Nicolas_upshifts" /id="D148" /incds=0 /nref=101 /ntot=231 /MaxReadThrough="0.41655" /MaxDrop="6.18136" /score="40.1548023" /energy="-12.6" /TU="NA" /idTUdmin="U256" /TUdmin="-9" /isTUend="TRUE" /label="downshifts" CDS complement(349562..350425) /gene="yckB" /locus_tag="BSU_03380" /old_locus_tag="BSU03380" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:23038252" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23038252; Product type t: transporter" /codon_start=1 /transl_table=11 /product="amino acid ABC transporter (binding lipoprotein subunit)" /protein_id="NP_388220.1" /db_xref="EnsemblGenomes-Gn:BSU03380" /db_xref="EnsemblGenomes-Tr:CAB12132" /db_xref="GOA:P42400" /db_xref="InterPro:IPR001638" /db_xref="InterPro:IPR018313" /db_xref="PDB:2IEE" /db_xref="SubtiList:BG11178" /db_xref="UniProtKB/Swiss-Prot:P42400" /translation="MKSFMHSKAVIFSFTMAFFLILAACSGKNEADSKDTGWEQIKDK GKIVVATSGTLYPTSYHDTDSGSDKLTGYEVEVVREAAKRLGLKVEFKEMGIDGMLTA VNSGQVDAAANDIDVTKDREEKFAFSTPYKYSYGTAIVRKDDLSGIKTLKDLKGKKAA GAATTVYMEVARKYGAKEVIYDNATNEQYLKDVANGRTDVILNDYYLQTLALAAFPDL NITIHPDIKYMPNKQALVMKKSNAALQKKMNEALKEMSKDGSLTKLSKQFFNKADVSK KIDADVQDVDL*" /label="yckB CDS" gene complement(349562..350425) /gene="yckB" /locus_tag="BSU_03380" /old_locus_tag="BSU03380" /label="yckB gene" promotor_-10 complement(350447..350466) /Source="Nicolas_upshift_promotors" /id="U256" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.791208791208791" /psig="0.983016983016983" /xcortree=1804 /SigmaFactorBS="caattcgaactttttgaaaacgcgatcaacaTATTGCAAccc cttatgttcaaTGCTATCTTTTTAGTTGATTaacagattgggggaactataggtgaaa t" /listShort="yckB, yckA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(350459) /Source="Nicolas_upshifts" /id="U256" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.791208791208791" /psig="0.983016983016983" /xcortree=1804 /SigmaFactorBS="caattcgaactttttgaaaacgcgatcaacaTATTGCAAccc cttatgttcaaTGCTATCTTTTTAGTTGATTaacagattgggggaactataggtgaaa t" /listShort="yckB, yckA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(350461..353295) /Source="Nicolas_S_feature" /locus_tag="new_368894_371728_c" /HighExp="GM 150, T-4.40H, G/S, Pyr, S2, C30, T-5.40H, C90, T-3.40H, T0.30H" /AntisenseName="bglC" /AntisenseCor="-0.37749573319969598" /AntisenseRegPval="-9.8000000000000007" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, Sig-" /TUshortPSig="0.248, 0.994, 0.0879" /TUlongSig="SigD" /TUlongPSig=1 /label="S122" promotor_-35 complement(350481..350488) /Source="Nicolas_upshift_promotors" /id="U256" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.791208791208791" /psig="0.983016983016983" /xcortree=1804 /SigmaFactorBS="caattcgaactttttgaaaacgcgatcaacaTATTGCAAccc cttatgttcaaTGCTATCTTTTTAGTTGATTaacagattgggggaactataggtgaaa t" /listShort="yckB, yckA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 350498..350504 /Source="Nicolas_upshift_promotors" /id="U257" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=154 /SigmaFactorBS="acataaggggttgcaatatgttgatcgCGTTTTCaaaaagtt cgaattGTGTATACAAAAAGCATGGgtgggtgtttaaaagcgtctatgaagggaagag g" /listShort="S123, yckC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 350519..350537 /Source="Nicolas_upshift_promotors" /id="U257" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=154 /SigmaFactorBS="acataaggggttgcaatatgttgatcgCGTTTTCaaaaagtt cgaattGTGTATACAAAAAGCATGGgtgggtgtttaaaagcgtctatgaagggaagag g" /listShort="S123, yckC" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 350531..350753 /Source="Nicolas_S_feature" /locus_tag="new_368964_369186" /HighExp="Etha, Salt, B60, Sw, B36, Gly, Heat, S6, Cold, S7" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99896700000000005" /TUshortSig="SigB" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S123" upshifts 350531 /Source="Nicolas_upshifts" /id="U257" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=154 /SigmaFactorBS="acataaggggttgcaatatgttgatcgCGTTTTCaaaaagtt cgaattGTGTATACAAAAAGCATGGgtgggtgtttaaaagcgtctatgaagggaagag g" /listShort="S123, yckC" /GFF_Attribute="listLong" /label="upshifts" CDS 350587..350784 /locus_tag="BSU_03385" /old_locus_tag="BSU03385" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513942.1" /translation="MSKDECQTYQGNACESEGCSRPVTHLCQYRKKWSRGMKPIFRIN LSLADAPKAYDIFDEKENGNI*" /label="hypothetical protein CDS" gene 350587..350784 /locus_tag="BSU_03385" /old_locus_tag="BSU03385" /label="gene" promotor_-35 350722..350727 /Source="Nicolas_upshift_promotors" /id="U258" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=779 /SigmaFactorBS="atgaaaccgatcttcagaataaatttaAGTCTTgctgatgcc cctaagGCATATGATATATTCGATGagaaagaaaatggaaacatttaaaccataatgg g" /listShort="yckC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 350743..350761 /Source="Nicolas_upshift_promotors" /id="U258" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=779 /SigmaFactorBS="atgaaaccgatcttcagaataaatttaAGTCTTgctgatgcc cctaagGCATATGATATATTCGATGagaaagaaaatggaaacatttaaaccataatgg g" /listShort="yckC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 350755 /Source="Nicolas_upshifts" /id="U258" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=779 /SigmaFactorBS="atgaaaccgatcttcagaataaatttaAGTCTTgctgatgcc cctaagGCATATGATATATTCGATGagaaagaaaatggaaacatttaaaccataatgg g" /listShort="yckC" /GFF_Attribute="listLong" /label="upshifts" CDS 350803..351258 /gene="yckC" /locus_tag="BSU_03390" /old_locus_tag="BSU03390" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406; Product type m:membrane component" /codon_start=1 /transl_table=11 /product="conserved integral membrane protein of unknown function" /protein_id="NP_388221.1" /db_xref="EnsemblGenomes-Gn:BSU03390" /db_xref="EnsemblGenomes-Tr:CAB12133" /db_xref="GOA:P42401" /db_xref="InterPro:IPR010432" /db_xref="SubtiList:BG11179" /db_xref="UniProtKB/Swiss-Prot:P42401" /translation="MNIYKPAGFWIRLGAALLDYIIVSVPLLLIYWLITGKDPNDSMF ISLVVLLYSILLPMFWRGYLIGKRICGIRIVKKDGSQVSLLTMFLRVIVAGLVYCITF GLGLIASLILIAVREDKRTLHDLIAGTYVTYATPGEEELNADEEIRKSE*" /label="yckC CDS" gene 350803..351258 /gene="yckC" /locus_tag="BSU_03390" /old_locus_tag="BSU03390" /label="yckC gene" downshifts 351233 /Source="Nicolas_upshifts" /id="D149" /incds=0 /nref=40 /ntot=193 /MaxReadThrough="1.14817" /MaxDrop="5.48303" /score="23.1539807" /energy="-9.8" /TU="NA" /idTUdmin="U257" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-35 351281..351287 /Source="Nicolas_upshift_promotors" /id="U259" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=899 /SigmaFactorBS="cgaagagattagaaagagcgaataatggttcgctctttttat ttttaTGCATAAaaaatacaaggcaGCAAAACATATGaaaaataggattggaggaata a" /listShort="yckD" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 351294 /Source="Nicolas_upshifts" /id="U259" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=899 /SigmaFactorBS="cgaagagattagaaagagcgaataatggttcgctctttttat ttttaTGCATAAaaaatacaaggcaGCAAAACATATGaaaaataggattggaggaata a" /listShort="yckD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 351301..351312 /Source="Nicolas_upshift_promotors" /id="U259" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=899 /SigmaFactorBS="cgaagagattagaaagagcgaataatggttcgctctttttat ttttaTGCATAAaaaatacaaggcaGCAAAACATATGaaaaataggattggaggaata a" /listShort="yckD" /GFF_Attribute="listLong" /label="promotor_-10" CDS 351340..351672 /gene="yckD" /locus_tag="BSU_03400" /old_locus_tag="BSU03400" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_388222.1" /db_xref="EnsemblGenomes-Gn:BSU03400" /db_xref="EnsemblGenomes-Tr:CAB12134" /db_xref="InterPro:IPR024485" /db_xref="SubtiList:BG11180" /db_xref="UniProtKB/Swiss-Prot:P42402" /translation="MKRITINIITMFIAAAVISLTGTAEAAEKQQQSPANVTLTDQQK KEIEQLEAEILKKRKDVISKYVQYGILPKERGEHIKNHLDKHFEMMKQNGFVPKHHPH PHKFEKRH*" /label="yckD CDS" gene 351340..351672 /gene="yckD" /locus_tag="BSU_03400" /old_locus_tag="BSU03400" /label="yckD gene" downshifts 351653 /Source="Nicolas_upshifts" /id="D150" /incds=0 /nref=20 /ntot=44 /MaxReadThrough="2.48743" /MaxDrop="4.3022" /score="-1.40416926" /energy="-11.8" /TU="NA" /idTUdmin="U259" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 351758..351765 /Source="Nicolas_upshift_promotors" /id="U260" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.936063936063936" /psig="0.953046953046953" /xcortree=1581 /SigmaFactorBS="caatattagctgagctgttccgcgactaacatcGAGTTGATa tgaaacgcgtttcaTAGCCTATGATAGGTTTATCaaataattcaggagtgataaacac t" /listShort="bglC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 351781..351800 /Source="Nicolas_upshift_promotors" /id="U260" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.936063936063936" /psig="0.953046953046953" /xcortree=1581 /SigmaFactorBS="caatattagctgagctgttccgcgactaacatcGAGTTGATa tgaaacgcgtttcaTAGCCTATGATAGGTTTATCaaataattcaggagtgataaacac t" /listShort="bglC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 351785 /Source="Nicolas_upshifts" /id="U260" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.936063936063936" /psig="0.953046953046953" /xcortree=1581 /SigmaFactorBS="caatattagctgagctgttccgcgactaacatcGAGTTGATa tgaaacgcgtttcaTAGCCTATGATAGGTTTATCaaataattcaggagtgataaacac t" /listShort="bglC" /GFF_Attribute="listLong" /label="upshifts" CDS 351826..353259 /gene="bglC" /locus_tag="BSU_03410" /old_locus_tag="BSU03410" /EC_number="3.2.1.86" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14652714, 15139916, 18069788" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14652714, 15139916, 18069788; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aryl-phospho-beta-d-glucosidase" /protein_id="NP_388223.1" /db_xref="EnsemblGenomes-Gn:BSU03410" /db_xref="EnsemblGenomes-Tr:CAB12135" /db_xref="GOA:P42403" /db_xref="InterPro:IPR001360" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR018120" /db_xref="InterPro:IPR033132" /db_xref="SubtiList:BG11181" /db_xref="UniProtKB/Swiss-Prot:P42403" /translation="MIHQHPESFPKHFLWGSASAAYQIEGAWNEDGKGPSVWDVFTKI PGKTFKGTNGEIAVDHYHRFKEDVALMAEMGLKAYRFSVSWPRVFPKGKGEINEAGLA FYDSLIDELLSHHIEPVLTLYHWDLPQALMDEYGGFESRNIIEDFNHYCITLYKRFGD RVKYWVTLNEQNYNFNHGFITAMHPPGVKDRKRFYEANHIAFLANAKAIESFREYVPE GKIGPSFAYSPAYPLSSHPEDILAFENAEEFTNNWWLDMYCWGTYPQIPFRCLEKQGW APTIEAGDMDLLAKGKPDFVGVNYYQTITYERNPLDGVSEGKMNTTGQKGTNQETGIP GVFKTKKNPHLTTSNWDWTIDPIGLRIGLRRITSRYQLPVFITENGLGEFDKVEDGTV QDDYRIDYLRSHLEQCRQAISDGVDLIGYCSWSFTDLLSWLNGYQKRYGFVYVNRDEE STSDLKRLKKKSFYWYQDVIKTNGESL*" /label="bglC CDS" gene 351826..353259 /gene="bglC" /locus_tag="BSU_03410" /old_locus_tag="BSU03410" /label="bglC gene" downshifts 353237 /Source="Nicolas_upshifts" /id="D151" /incds=0 /nref=12 /ntot=61 /MaxReadThrough="1.51167" /MaxDrop="4.6748" /score="18.0928088" /energy="-15.9" /TU="NA" /idTUdmin="U260" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(353296..353694) /gene="nin" /locus_tag="BSU_03420" /old_locus_tag="BSU03420" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11359569, 11814663, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11359569, 11814663, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="inhibitor of the DNA degrading activity of NucA (competence)" /protein_id="NP_388224.1" /db_xref="EnsemblGenomes-Gn:BSU03420" /db_xref="EnsemblGenomes-Tr:CAB12136" /db_xref="GOA:P12669" /db_xref="InterPro:IPR020354" /db_xref="PDB:4MQD" /db_xref="SubtiList:BG10839" /db_xref="UniProtKB/Swiss-Prot:P12669" /translation="MIKSWKPQELSISYHQFTVFQKDSTPPVMDWTDEAIEKGYAAAD GAISFEAQRNTKAFILFRLNSSETVNSYEKKVTVPFHVTENGIHIESIMSKRLSFDLP KGDYQLTCWTVPAEMSDLHADTYIIDAVSV*" /label="nin CDS" gene complement(353296..353694) /gene="nin" /locus_tag="BSU_03420" /old_locus_tag="BSU03420" /label="nin gene" promotor_no_box complement(353691..353791) /Source="Nicolas_upshift_promotors" /id="U261" /multdbtbs="-" /comp="M18" /sig="Sig-" /pcomp="0.234765234765235" /psig="0.247752247752248" /xcortree=1715 /SigmaFactorBS="caggctcttgggtcgggcatcggcttaccgattacccagacg gcacaaaggttttattcacaattcagtaaacagtacatagaggaggaacagcacattg a" /listShort="nin, S122" /GFF_Attribute="listLong" /label="promotor_no_box" CDS complement(353721..354170) /gene="nucA" /locus_tag="BSU_03430" /old_locus_tag="BSU03430" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:2841296, 7746143, 11359569, 11814663" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2841296, 7746143, 11359569, 11814663; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endonuclease" /protein_id="NP_388225.3" /db_xref="EnsemblGenomes-Gn:BSU03430" /db_xref="EnsemblGenomes-Tr:CAB12137" /db_xref="GOA:P12667" /db_xref="InterPro:IPR029476" /db_xref="SubtiList:BG10838" /db_xref="UniProtKB/Swiss-Prot:P12667" /translation="MNITTDIIKTILLVIVIIAAAAVGLIKGDFFSADQKTSQTKEYD ETMAFPSDRYPETAKHIKDAINEGHSEVCTIDRDGAEERREQSLKDVPSKKGYDRDEW PMAMCKEGGEGASVEYISPADNRGAGSWVGHRLTDYPDGTKVLFTIQ*" /label="nucA CDS" gene complement(353721..354170) /gene="nucA" /locus_tag="BSU_03430" /old_locus_tag="BSU03430" /label="nucA gene" upshifts complement(353731) /Source="Nicolas_upshifts" /id="U261" /multdbtbs="-" /comp="M18" /sig="Sig-" /pcomp="0.234765234765235" /psig="0.247752247752248" /xcortree=1715 /SigmaFactorBS="caggctcttgggtcgggcatcggcttaccgattacccagacg gcacaaaggttttattcacaattcagtaaacagtacatagaggaggaacagcacattg a" /listShort="nin, S122" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(354185..354204) /Source="Nicolas_upshift_promotors" /id="U262" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.994005994005994" /xcortree=2957 /SigmaFactorBS="taaactgatcgtaaaacataaaatttaaACCTTTACaccaaa tgctttcTGGATTACTCTTGTGTCAGTtttaaaagcgggaggtgaacatcacgacgga c" /listShort="nucA, nin, S122, yckB, yckA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(354193) /Source="Nicolas_upshifts" /id="U262" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.994005994005994" /xcortree=2957 /SigmaFactorBS="taaactgatcgtaaaacataaaatttaaACCTTTACaccaaa tgctttcTGGATTACTCTTGTGTCAGTtttaaaagcgggaggtgaacatcacgacgga c" /listShort="nucA, nin, S122, yckB, yckA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(354195..354337) /Source="Nicolas_S_feature" /locus_tag="new_372628_372770_c" /HighExp="C30, Diami, M40t45, Cold, Lbstat, T0.30H, M0t90, dia15, C90, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigD" /TUshortPSig="0.0879, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S124" promotor_-35 complement(354218..354225) /Source="Nicolas_upshift_promotors" /id="U262" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.994005994005994" /xcortree=2957 /SigmaFactorBS="taaactgatcgtaaaacataaaatttaaACCTTTACaccaaa tgctttcTGGATTACTCTTGTGTCAGTtttaaaagcgggaggtgaacatcacgacgga c" /listShort="nucA, nin, S122, yckB, yckA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(354338..356059) /gene="tlpC" /locus_tag="BSU_03440" /old_locus_tag="BSU03440" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:7704255, 7921238, 15187186, 27899502" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7704255, 7921238, 15187186, 27899502; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="methyl-accepting chemotaxis protein (plant colonization)" /protein_id="NP_388226.2" /db_xref="EnsemblGenomes-Gn:BSU03440" /db_xref="EnsemblGenomes-Tr:CAB12138" /db_xref="GOA:P39209" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR004090" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR033463" /db_xref="SubtiList:BG10790" /db_xref="UniProtKB/Swiss-Prot:P39209" /translation="MLIKRFKMKLGTKILCLVFVVILLFSASVGTVMLKEITESMKQM ATEKAKGDLALSSTYIDDVMSGDWQVKNNKLYKGQTQINGNEDIVDLLGEKTGDTITI FQGDTRVATNVMKNGERAVGTQASSEVIAAVLKKGKRFYGQADVAGSSYQTAYMPLKD QNGNIIGMLYTGANQSILASLTQSLFTQFAIVLVIVIMVSVILVLVFTRKINKRLNAL KSAFESAGNGDMTIEVSDKTGDELSELSVYYNKMRMKLNDTIQTVQQSALQLASASQQ LSAGAEETNQASEKITEAVQQIANGAQDQITRIENSESSLKQASADIRDISANTAAIA DKGQLAQSKADIGQKEIANVQAQMDAIHQSIQKSGEIIHQLDGRSKQIEQILSVITQI ADQTNLLALNAAIEAARAGEQGKGFAVVADEVRKLAEESQQSAGQISKLIIEIQKDMN RSARSVEHVKTEAAEGVTMIQRTRDAFKEIAAATGEISAEISDLSASVTNISASAHQI NDSFAANTADIKESTKNTRQAAALTEEQFAAMEEITAASETLSQLAEELTGIISQFKM INQAENG*" /label="tlpC CDS" gene complement(354338..356059) /gene="tlpC" /locus_tag="BSU_03440" /old_locus_tag="BSU03440" /label="tlpC gene" promotor_-35 354350..354357 /Source="Nicolas_upshift_promotors" /id="U263" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig="0.996003996003996" /xcortree=2959 /SigmaFactorBS="ttgccaatttacaataatgatagtaagtcatcagccgttttc GGCTTGATtaatcattttaaatTGGCTTATGATACCGGTAAGctcctcagctaattga g" /listShort="S125, hxlR" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 354368..357511 /Source="Nicolas_S_feature" /locus_tag="new_372801_375944" /HighExp="T1.0H, T1.30H, T0.30H, T2.0H, T2.30H, T3.0H, T3.30H, T4.0H, T0.0H, T-0.40H" /AntisenseName="tlpC" /AntisenseCor="-0.40398083053643302" /AntisenseRegPval="-11.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S125" upshifts 354368 /Source="Nicolas_upshifts" /id="U263" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig="0.996003996003996" /xcortree=2959 /SigmaFactorBS="ttgccaatttacaataatgatagtaagtcatcagccgttttc GGCTTGATtaatcattttaaatTGGCTTATGATACCGGTAAGctcctcagctaattga g" /listShort="S125, hxlR" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 354372..354391 /Source="Nicolas_upshift_promotors" /id="U263" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig="0.996003996003996" /xcortree=2959 /SigmaFactorBS="ttgccaatttacaataatgatagtaagtcatcagccgttttc GGCTTGATtaatcattttaaatTGGCTTATGATACCGGTAAGctcctcagctaattga g" /listShort="S125, hxlR" /GFF_Attribute="listLong" /label="promotor_-10" promotor_no_box complement(354373..354473) /Source="Nicolas_upshift_promotors" /id="U264" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.452547452547453" /psig="0.0879120879120879" /xcortree=2190 /SigmaFactorBS="ggctgcattaacagaggagcaatttgctgcaatggaggagat taccgcagcttctgaaacactttctcaattagctgaggagcttaccggtatcataagc c" /listShort="S124, nucA, nin, S122" /listLong="yckB, yckA" /label="promotor_no_box" upshifts complement(354413) /Source="Nicolas_upshifts" /id="U264" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.452547452547453" /psig="0.0879120879120879" /xcortree=2190 /SigmaFactorBS="ggctgcattaacagaggagcaatttgctgcaatggaggagat taccgcagcttctgaaacactttctcaattagctgaggagcttaccggtatcataagc c" /listShort="S124, nucA, nin, S122" /listLong="yckB, yckA" /label="upshifts" promotor_-10 complement(356083..356101) /Source="Nicolas_upshift_promotors" /id="U265" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2796 /SigmaFactorBS="cggcctgaagatcaggccggttttattttttctaaaATAAAA CTttaaacccaaaaaCCCGATAAGTAATATGACCtgcaaatcgtaaagggaggaatta t" /listShort="tlpC, S124, nucA, nin" /listLong="S122" /label="promotor_-10" upshifts complement(356098) /Source="Nicolas_upshifts" /id="U265" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2796 /SigmaFactorBS="cggcctgaagatcaggccggttttattttttctaaaATAAAA CTttaaacccaaaaaCCCGATAAGTAATATGACCtgcaaatcgtaaagggaggaatta t" /listShort="tlpC, S124, nucA, nin" /listLong="S122" /label="upshifts" promotor_-35 complement(356115..356122) /Source="Nicolas_upshift_promotors" /id="U265" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2796 /SigmaFactorBS="cggcctgaagatcaggccggttttattttttctaaaATAAAA CTttaaacccaaaaaCCCGATAAGTAATATGACCtgcaaatcgtaaagggaggaatta t" /listShort="tlpC, S124, nucA, nin" /listLong="S122" /label="promotor_-35" CDS complement(356170..356727) /gene="hxlB" /locus_tag="BSU_03450" /old_locus_tag="BSU03450" /EC_number="5.3.1.27" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10572115, 15978081" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10572115, 15978081; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="6-phospho-3-hexuloisomerase (PHI)" /protein_id="NP_388227.1" /db_xref="EnsemblGenomes-Gn:BSU03450" /db_xref="EnsemblGenomes-Tr:CAB12139" /db_xref="GOA:P42404" /db_xref="InterPro:IPR001347" /db_xref="InterPro:IPR017552" /db_xref="PDB:1M3S" /db_xref="PDB:1VIV" /db_xref="SubtiList:BG11182" /db_xref="UniProtKB/Swiss-Prot:P42404" /translation="MKTTEYVAEILNELHNSAAYISNEEADQLADHILSSHQIFTAGA GRSGLMAKSFAMRLMHMGFNAHIVGEILTPPLAEGDLVIIGSGSGETKSLIHTAAKAK SLHGIVAALTINPESSIGKQADLIIRMPGSPKDQSNGSYKTIQPMGSLFEQTLLLFYD AVILKLMEKKGLDSETMFTHHANLE*" /label="hxlB CDS" gene complement(356170..356727) /gene="hxlB" /locus_tag="BSU_03450" /old_locus_tag="BSU03450" /label="hxlB gene" downshifts complement(356173) /Source="Nicolas_upshifts" /id="D152" /incds=0 /nref=51 /ntot=130 /MaxReadThrough="1.98332" /MaxDrop="6.56052" /score="42.3682356" /energy="-15.4" /TU="NA" /idTUdmin="U266" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(356733..357365) /gene="hxlA" /locus_tag="BSU_03460" /old_locus_tag="BSU03460" /EC_number="4.1.2.43" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10572115, 15978081" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10572115, 15978081; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-hexulose-6-phosphate synthase (HPS)" /protein_id="NP_388228.1" /db_xref="EnsemblGenomes-Gn:BSU03460" /db_xref="EnsemblGenomes-Tr:CAB12140" /db_xref="GOA:P42405" /db_xref="InterPro:IPR001754" /db_xref="InterPro:IPR011060" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR017553" /db_xref="SubtiList:BG11183" /db_xref="UniProtKB/Swiss-Prot:P42405" /translation="MELQLALDLVNIPEAIELVKEVEQYIDVVEIGTPVVINEGLRAV KEIKEAFPQLKVLADLKIMDAGGYEIMKASEAGADIITVLGATDDATIKGAVEEAKKQ KKKILVDMINVKDIESRAKEIDALGVDYICVHTGYDLQAEGKNSFEELTTIKNTVKNA KTAIAGGIKLDTLPEVIQQKPDLVIVGGGITSAADKAETASKMKQLIVQG*" /label="hxlA CDS" gene complement(356733..357365) /gene="hxlA" /locus_tag="BSU_03460" /old_locus_tag="BSU03460" /label="hxlA gene" promotor_-10 complement(357391..357410) /Source="Nicolas_upshift_promotors" /id="U266" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.658341658341658" /psig="0.987012987012987" /xcortree=1517 /SigmaFactorBS="agtatcctccaagtaacttgttgacttcaaagtgcctaCTTC tcaacaaaagaaggAACCTATAGAATGAACAATAattcgaaaaagggagtggatcaac a" /listShort="hxlA, hxlB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(357406) /Source="Nicolas_upshifts" /id="U266" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.658341658341658" /psig="0.987012987012987" /xcortree=1517 /SigmaFactorBS="agtatcctccaagtaacttgttgacttcaaagtgcctaCTTC tcaacaaaagaaggAACCTATAGAATGAACAATAattcgaaaaagggagtggatcaac a" /listShort="hxlA, hxlB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(357425..357428) /Source="Nicolas_upshift_promotors" /id="U266" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.658341658341658" /psig="0.987012987012987" /xcortree=1517 /SigmaFactorBS="agtatcctccaagtaacttgttgacttcaaagtgcctaCTTC tcaacaaaagaaggAACCTATAGAATGAACAATAattcgaaaaagggagtggatcaac a" /listShort="hxlA, hxlB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 357489..357492 /Source="Nicolas_upshift_promotors" /id="U267" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.536463536463537" /psig=1 /xcortree=1957 /SigmaFactorBS="acttggaggatactgtgaggagagacaatcagatttCTTTcg cttgattttatgAGTGAGTATAATGAAAAAAGagtctgcaaaaaagtaagtaagtgat g" /listShort="hxlR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 357507..357526 /Source="Nicolas_upshift_promotors" /id="U267" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.536463536463537" /psig=1 /xcortree=1957 /SigmaFactorBS="acttggaggatactgtgaggagagacaatcagatttCTTTcg cttgattttatgAGTGAGTATAATGAAAAAAGagtctgcaaaaaagtaagtaagtgat g" /listShort="hxlR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 357513 /Source="Nicolas_upshifts" /id="U267" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.536463536463537" /psig=1 /xcortree=1957 /SigmaFactorBS="acttggaggatactgtgaggagagacaatcagatttCTTTcg cttgattttatgAGTGAGTATAATGAAAAAAGagtctgcaaaaaagtaagtaagtgat g" /listShort="hxlR" /GFF_Attribute="listLong" /label="upshifts" CDS 357599..357961 /gene="hxlR" /locus_tag="BSU_03470" /old_locus_tag="BSU03470" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15978081, 26973631" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15978081, 26973631; Product type r: regulator" /codon_start=1 /transl_table=11 /product="positive regulator of hxlAB expression (formaldehyde sensing)" /protein_id="NP_388229.2" /db_xref="EnsemblGenomes-Gn:BSU03470" /db_xref="EnsemblGenomes-Tr:CAB12141" /db_xref="GOA:P42406" /db_xref="InterPro:IPR002577" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11184" /db_xref="UniProtKB/Swiss-Prot:P42406" /translation="MSRMDDKRFNCEKELTLAVIGGKWKMLILWHLGKEGTKRFNELK TLIPDITQKILVNQLRELEQDMIVHREVYPVVPPKVEYSLTPHGESLMPILEAMYEWG KGYMELIDIDKNVMKESL*" /label="hxlR CDS" gene 357599..357961 /gene="hxlR" /locus_tag="BSU_03470" /old_locus_tag="BSU03470" /label="hxlR gene" downshifts 357945 /Source="Nicolas_upshifts" /id="D153" /incds=0 /nref=14 /ntot=154 /MaxReadThrough="3.13609" /MaxDrop="3.66949" /score="20.4643411" /energy="-9.6" /TU="U267" /idTUdmin="U263" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-35 358208..358211 /Source="Nicolas_upshift_promotors" /id="U268" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.658341658341658" /psig="0.994005994005994" /xcortree=3241 /SigmaFactorBS="cggcatcccgcatgaaacttttcacccatttttcGGTGataa aaacatttttTTCATTTAAACTGAACGGTAgaaagataaaaaatattgaaaacaatga a" /listShort="S126, srfAA, srfAB, comS, srfAC, srfAD, ycxA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 358226..358245 /Source="Nicolas_upshift_promotors" /id="U268" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.658341658341658" /psig="0.994005994005994" /xcortree=3241 /SigmaFactorBS="cggcatcccgcatgaaacttttcacccatttttcGGTGataa aaacatttttTTCATTTAAACTGAACGGTAgaaagataaaaaatattgaaaacaatga a" /listShort="S126, srfAA, srfAB, comS, srfAC, srfAD, ycxA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 358234..358534 /Source="Nicolas_S_feature" /locus_tag="new_376667_376967" /HighExp="HiOs, T-1.10H, T5.0H, T4.0H, T-1.40H, S2, M9-stat, T3.30H, T0.0H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.20585600000000001" /TUshortSig="SigA" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S126" upshifts 358234 /Source="Nicolas_upshifts" /id="U268" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.658341658341658" /psig="0.994005994005994" /xcortree=3241 /SigmaFactorBS="cggcatcccgcatgaaacttttcacccatttttcGGTGataa aaacatttttTTCATTTAAACTGAACGGTAgaaagataaaaaatattgaaaacaatga a" /listShort="S126, srfAA, srfAB, comS, srfAC, srfAD, ycxA" /GFF_Attribute="listLong" /label="upshifts" CDS 358535..369298 /gene="srfAA" /locus_tag="BSU_03480" /old_locus_tag="BSU03480" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15066026, 16166527, 8288534, 8441623, 14762003, 16707694, 26284661, 26268540, 14762003" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15066026, 16166527, 8288534, 8441623, 14762003, 16707694, 26284661, 26268540, 14762003; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="surfactin synthetase" /protein_id="NP_388230.2" /db_xref="EnsemblGenomes-Gn:BSU03480" /db_xref="EnsemblGenomes-Tr:CAB12142" /db_xref="GOA:P27206" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR001242" /db_xref="InterPro:IPR006162" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR010060" /db_xref="InterPro:IPR010071" /db_xref="InterPro:IPR013321" /db_xref="InterPro:IPR020806" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="InterPro:IPR036736" /db_xref="SubtiList:BG10168" /db_xref="UniProtKB/Swiss-Prot:P27206" /translation="MEITFYPLTDAQKRIWYTEKFYPHTSISNLAGIGKLVSADAIDY VLVEQAIQEFIRRNDAMRLRLRLDENGEPVQYISEYRPVDIKHTDTTEDPNAIEFISQ WSREETKKPLPLYDCDLFRFSLFTIKENEVWFYANVHHVISDGISMNILGNAIMHIYL ELASGSETKEGISHSFIDHVLSEQEYAQSKRFEKDKAFWNKQFESVPELVSLKRNASA GGSLDAERFSKDVPEALHQQILSFCEANKVSVLSVFQSLLAAYLYRVSGQNDVVTGTF MGNRTNAKEKQMLGMFVSTVPLRTNIDGGQAFSEFVKDRMKDLMKTLRHQKYPYNLLI NDLRETKSSLTKLFTVSLEYQVMQWQKEEDLAFLTEPIFSGSGLNDVSIHVKDRWDTG KLTIDFDYRTDLFSREEINMICERMITMLENALTHPEHTIDELTLISDAEKEKLLARA GGKSVSYRKDMTIPELFQEKAELLSDHPAVVFEDRTLSYRTLHEQSARIANVLKQKGV GPDSPVAVLIERSERMITAIMGILKAGGAYVPIDPGFPAERIQYILEDCGADFILTES KVAAPEADAELIDLDQAIEEGAEESLNADVNARNLAYIIYTSGTTGRPKGVMIEHRQV HHLVESLQQTIYQSGSQTLRMALLAPFHFDASVKQIFASLLLGQTLYIVPKKTVTNGA ALTAYYRKNSIEATDGTPAHLQMLAAAGDFEGLKLKHMLIGGEGLSSVVADKLLKLFK EAGTAPRLTNVYGPTETCVDASVHPVIPENAVQSAYVPIGKALGNNRLYILDQKGRLQ PEGVAGELYIAGDGVGRGYLHLPELTEEKFLQDPFVPGDRMYRTGDVVRWLPDGTIEY LGREDDQVKVRGYRIELGEIEAVIQQAPDVAKAVVLARPDEQGNLEVCAYVVQKPGSE FAPAGLREHAARQLPDYMVPAYFTEVTEIPLTPSGKVDRRKLFALEVKAVSGTAYTAP RNETEKAIAAIWQDVLNVEKAGIFDNFFETGGHSLKAMTLLTKIHKETGIEIPLQFLF EHPTITALAEEADHRESKAFAVIEPAEKQEHYPLSLAQQRTYIVSQFEDAGVGYNMPA AAILEGPLDIQKLERAFQGLIRRHESLRTSFVLENSTPRQKIHDSVDFNIEMIERGGR SDEAIMASFVRTFDLAKAPLFRIGLLGLEENRHMLLFDMHHLISDGVSIGIMLEELAR IYKGEQLPDLRLQYKDYAVWQSRQAAEGYKKDQAYWKEVFAGELPVLQLLSDYPRPPV QSFEGDRVSIKLDAGVKDRLNRLAEQNGATLYMVMLSAYYTLLSKYTGQDDIIVGTPS AGRNHSDTEGIIGMFVNTLAIRSEVKQNETFTQLISRVRKRVLDAFSHQDYPFEWLVE DLNIPRDVSRHPLFDTMFSLQNATEGIPAVGDLSLSVQETNFKIAKFDLTVQARETDE GIEIDVDYSTKLFKQSTADRLLTHFARLLEDAAADPEKPISEYKLLSEEEAASQIQQF NPGRTPYPKDKTIVQLFEEQAANTPDHTALQYEGESLTYRELNERANRLARGILSLGA GEGRTAAVLCERSMDMIVSILAVLKSGSAYVPIDPEHPIQRMQHFFRDSGAKVLLTQR KLKALAEEAEFKGVIVLADEEESYHADARNLALPLDSAAMANLTYTSGTTGTPKGNIV THANILRTVKETNYLSITEQDTILGLSNYVFDAFMFDMFGSLLNGAKLVLIPKETVLD MARLSRVIERENISILMITTALFHLLVDLNPACLSTLRKIMFGGERASVEHVRKALQT VGKGKLLHMYGPSESTVFATYHPVDELEEHTLSVPIGKPVSNTEVYILDRTGHVQPAG IAGELCVSGEGLVKGYYNRPELTEEKFVPHPFTSGERMYKTGDLARWLPNGDIEFIGR IDHQVKIRGQRIELGEIEHQLQTHDRVQESVVLAVDQGAGDKLLCAYYVGEGDISSQE MREHAAKDLPAYMVPAVFIQMDELPLTGNGKIDRRALPIPDANVSRGVSYVAPRNGTE QKVADIWAQVLQAEQVGAYDHFFDIGGHSLAGMKMLALVHQELGVELSLKDLFQSPTV EGLAQVIASAEKGTAASISPAEKQDTYPVSSPQKRMYVLQQLEDAQTSYNMPAVLRLT GELDVERLNSVMQQLMQRHEALRTTFEIKDGETVQRIWEEAECEIAYFEAPEEETERI VSEFIKPFKIDQLPLFRIGLIKHSDTEHVLLFDMHHIISDGASVGVLIEELSKLYDGE TLEPLRIQYKDYAVWQQQFIQSELYKKQEEHWLKELDGELPVLTLPTDYSRPAVQTFE GDRIAFSLEAGKADALRRLAKETDSTLYMVLLASYSAFLSKISGQDDIIVGSPVAGRS QADVSRVIGMFVNTLALRTYPKGEKTFADYLNEVKETALSAFDAQDYPLEDLIGNVQV QRDTSRNPLFDAVFSMQNANIKDLTMKGIQLEPHPFERKTAKFDLTLTADETDGGLTF VLEYNTALFKQETIERWKQYWMELLDAVTGNPNQPLSSLSLVTETEKQALLEAWKGKA LPVPTDKTVHQLFEETAQRHKDRPAVTYNGQSWTYGELNAKANRLARILMDCGISPDD RVGVLTKPSLEMSAAVLGVLKAGAAFVPIDPDYPDQRIEYILQDSGAKLLLKQEGISV PDSYTGDVILLDGSRTILSLPLDENDEENPETAVTAENLAYMIYTSGTTGQPKGVMVE HHALVNLCFWHHDAFSMTAEDRSAKYAGFGFDASIWEMFPTWTIGAELHVIEEAIRLD IVRLNDYFETNGVTITFLPTQLAEQFMELENTSLRVLLTGGDKLKRAVKKPYTLVNNY GPTENTVVATSAEIHPEEGSLSIGRAIANTRVYILGEGNQVQPEGVAGELCVAGRGLA RGYLNREDETAKRFVADPFVPGERMYRTGDLVKWTGGGIEYIGRIDQQVKVRGYRIEL SEIEVQLAQLSEVQDAAVTAVKDKGGNTAIAAYVTPESADIEALKSALKETLPDYMIP AFWVTLNELPVTANGKVDRKALPEPDIEAGSGEYKAPTTDMEELLAGIWQDVLGMSEV GVTDNFFSLGGDSIKGIQMASRLNQHGWKLEMKDLFQHPTIEELTQYVERAEGKQADQ GPVEGEVILTPIQRWFFEKNFTNKHHWNQSVMLHAKKGFDPERVEKTLQALIEHHDAL RMVYREGQEDVIQYNRGLEAASAQLEVIQIEGQAADYEDRIEREAERLQSSIDLQEGG LLKAGLFQAEDGDHLLLAIHHLVVDGVSWRILLEDFAAVYTQLEQGNEPVLPQKTHSF AEYAERLQDFANSKAFLKEKEYWRQLEEQAVAAKLPKDRESGDQRMKHTKTIEFSLTA EETEQLTTKVHEAYHTEMNDILLTAFGLAMKEWTGQDRVSVHLEGHGREEIIEDLTIS RTVGWFTSMYPMVLDMKHADDLGYQLKQMKEDIRHVPNKGVGYGILRYLTAPEHKEDV AFSIQPDVSFNYLGQFDEMSDAGLFTRSELPSGQSLSPETEKPNALDVVGYIENGKLT MSLAYHSLEFHEKTVQTFSDSFKAHLLRIIEHCLSQDGTELTPSDLGDDDLTLDELDK LMEIF*" /label="srfAA CDS" gene 358535..369298 /gene="srfAA" /locus_tag="BSU_03480" /old_locus_tag="BSU03480" /label="srfAA gene" CDS 369311..380062 /gene="srfAB" /locus_tag="BSU_03490" /old_locus_tag="BSU03490" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15066026, 16166527, 16553878, 17227471, 14762003, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15066026, 16166527, 16553878, 17227471, 14762003, 26284661; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="surfactin synthetase" /protein_id="NP_388231.2" /db_xref="EnsemblGenomes-Gn:BSU03490" /db_xref="EnsemblGenomes-Tr:CAB12143" /db_xref="GOA:Q04747" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR001242" /db_xref="InterPro:IPR006162" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR010060" /db_xref="InterPro:IPR010071" /db_xref="InterPro:IPR020806" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="InterPro:IPR036736" /db_xref="SubtiList:BG10169" /db_xref="UniProtKB/Swiss-Prot:Q04747" /translation="MSKKSIQKVYALTPMQEGMLYHAMLDPHSSSYFTQLELGIHGAF DLEIFEKSVNELIRSYDILRTVFVHQQLQKPRQVVLAERKTKVHYEDISHADENRQKE HIERYKQDVQRQGFNLAKDILFKVAVFRLAADQLYLVWSNHHIMMDGWSMGVLMKSLF QNYEALRAGRTPANGQGKPYSDYIKWLGKQDNEEAESYWSERLAGFEQPSVLPGRLPV KKDEYVNKEYSFTWDETLVARIQQTANLHQVTGPNLFQAVWGIVLSKYNFTDDVIFGT VVSGRPSEINGIETMAGLFINTIPVRVKVERDAAFADIFTAVQQHAVEAERYDYVPLY EIQKRSALDGNLLNHLVAFENYPLDQELENGSMEDRLGFSIKVESAFEQTSFDFNLIV YPGKTWTVKIKYNGAAFDSAFIERTAEHLTRMMEAAVDQPAAFVREYGLVGDEEQRQI VEVFNSTKAELPEGMAVHQVFEEQAKRTPASTAVVYEGTKLTYRELNAAANRLARKLV EHGLQKGETAAIMNDRSVETVVGMLAVLKAGAAYVPLDPALPGDRLRFMAEDSSVRMV LIGNSYTGQAHQLQVPVLTLDIGFEESEAADNLNLPSAPSDLAYIMYTSGSTGKPKGV MIEHKSILRLVKNAGYVPVTEEDRMAQTGAVSFDAGTFEVFGALLNGAALYPVKKETL LDAKQFAAFLREQSITTMWLTSPLFNQLAAKDAGMFGTLRHLIIGGDALVPHIVSKVK QASPSLSLWNGYGPTENTTFSTSFLIDREYGGSIPIGKPIGNSTAYIMDEQQCLQPIG APGELCVGGIGVARGYVNLPELTEKQFLEDPFRPGERIYRTGDLARWLPDGNIEFLGR IDNQVKVRGFRIELGEIETKLNMAEHVTEAAVIIRKNKADENEICAYFTADREVAVSE LRKTLSQSLPDYMVPAHLIQMDSLPLTPNGKINKKELPAPQSEAVQPEYAAPKTESEK KLAEIWEGILGVKAGVTDNFFMIGGHSLKAMMMTAKIQEHFHKEVPIKVLFEKPTIQE LALYLEENESKEEQTFEPIRQASYQQHYPVSPAQRRMYILNQLGQANTSYNVPAVLLL EGEVDKDRLENAIQQLINRHEILRTSFDMIDGEVVQTVHKNISFQLEAAKGREEDAEE IIKAFVQPFELNRAPLVRSKLVQLEEKRHLLLIDMHHIITDGSSTGILIGDLAKIYQG ADLELPQIHYKDYAVWHKEQTNYQKDEEYWLDVFKGELPILDLPADFERPAERSFAGE RVMFGLDKQITAQIKSLMAETDTTMYMFLLAAFNVLLSKYASQDDIIVGSPTAGRTHP DLQGVPGMFVNTVALRTAPAGDKTFAQFLEEVKTASLQAFEHQSYPLEELIEKLPLTR DTSRSPLFSVMFNMQNMEIPSLRLGDLKISSYSMLHHVAKFDLSLEAVEREEDIGLSF DYATALFKDETIRRWSRHFVNIIKAAAANPNVRLSDVDLLSSAETAALLEERHMTQIT EATFAALFEKQAQQTPDHSAVKAGGNLLTYRELDEQANQLAHHLRAQGAGNEDIVAIV MDRSAEVMVSILGVMKAGAAFLPIDPDTPEERIRYSLEDSGAKFAVVNERNMTAIGQY EGIIVSLDDGKWRNESKERPSSISGSRNLAYVIYTSGTTGKPKGVQIEHRNLTNYVSW FSEEAGLTENDKTVLLSSYAFDLGYTSMFPVLLGGGELHIVQKETYTAPDEIAHYIKE HGITYIKLTPSLFHTIVNTASFAKDANFESLRLIVLGGEKIIPTDVIAFRKMYGHTEF INHYGPTEATIGAIAGRVDLYEPDAFAKRPTIGRPIANAGALVLNEALKLVPPGASGQ LYITGQGLARGYLNRPQLTAERFVENPYSPGSLMYKTGDVVRRLSDGTLAFIGRADDQ VKIRGYRIEPKEIETVMLSLSGIQEAVVLAVSEGGLQELCAYYTSDQDIEKAELRYQL SLTLPSHMIPAFFVQVDAIPLTANGKTDRNALPKPNAAQSGGKALAAPETALEESLCR IWQKTLGIEAIGIDDNFFDLGGHSLKGMMLIANIQAELEKSVPLKALFEQPTVRQLAA YMEASAVSGGHQVLKPADKQDMYPLSSAQKRMYVLNQLDRQTISYNMPSVLLMEGELD ISRLRDSLNQLVNRHESLRTSFMEANGEPVQRIIEKAEVDLHVFEAKEDEADQKIKEF IRPFDLNDAPLIRAALLRIEAKKHLLLLDMHHIIADGVSRGIFVKELALLYKGEQLPE PTLHYKDFAVWQNEAEQKERMKEHEAYWMSVLSGELPELDLPLDYARPPVQSFKGDTI RFRTGSETAKAVEKLLAETGTTLHMVLHAVFHVFLSKISGQRDIVIGSVTAGRTNADV QDMPGMFVNTLALRMEAKEQQTFAELLELAKQTNLSALEHQEYPFEDLVNQLDLPRDM SRNPLFNVMVTTENPDKEQLTLQNLSISPYEAHQGTSKFDLTLGGFTDENGIGLQLEY ATDLFAKETAEKWSEYVLRLLKAVADNPNQPLSSLLLVTETEKQALLEAWKGKALPVP TDKTVHQLFEETVQRHKDRPAVTYNGQSWTYGELNAKANRLARILMDCGISPDDRVGV LTKPSLEMSAAVLGVLKAGAAFVPIDPDYPDQRIEYILQDSGAKLLLKQEGISVPDSY TGDVILLDGSRTILSLPLDENDEGNPETAVTAENLAYMIYTSGTTGQPKGVMVEHHAL VNLCFWHHDAFSMTAEDRSAKYAGFGFDASIWEMFPTWTIGAELHVIDEAIRLDIVRL NDYFETNGVTITFLPTQLAEQFMELENTSLRVLLTGGDKLKRAVKKPYTLVNNYGPTE NTVVATSAEIHPEEGSLSIGRAIANTRVYILGEGNQVQPEGVAGELCVAGRGLARGYL NREDETAKRFVADPFVPGERMYRTGDLVKWVNGGIEYIGRIDQQVKVRGYRIELSEIE VQLAQLSEVQDAAVTAVKDKGGNTAIAAYVTPETADIEALKSTLKETLPDYMIPAFWV TLNELPVTANGKVDRKALPEPDIEAGSGEYKAPTTDMEELLAGIWQDVLGMSEVGVTD NFFSLGGDSIKGIQMASRLNQHGWKLEMKDLFQHPTIEELTQYVERAEGKQADQGPVE GEVILTPIQRWFFEKNFTNKHHWNQSVMLHAKKGFDPERVEKTLQALIEHHDALRMVY REENGDIVQVYKPIGESKVSFEIVDLYGSDEEMLRSQIKLLANKLQSSLDLRNGPLLK AEQYRTEAGDHLLIAVHHLVVDGVSWRILLEDFASGYMQAEKEESLVFPQKTNSFKDW AEELAAFSQSAHLLQQAEYWSQIAAEQVSPLPKDCETEQRIVKDTSSVLCELTAEDTK HLLTDVHQPYGTEINDILLSALGLTMKEWTKGAKIGINLEGHGREDIIPNVNISRTVG WFTAQYPVVLDISDADASAVIKTVKENLRRIPDKGVGYGILRYFTETAETKGFTPEIS FNYLGQFDSEVKTDFFEPSAFDMGRQVSGESEALYALSFSGMIRNGRFVLSCSYNEKE FERATVEEQMERFKENLLMLIRHCTEKEDKEFTPSDFSAEDLEMDEMGDIFDMLEENL K*" /label="srfAB CDS" gene 369311..380062 /gene="srfAB" /locus_tag="BSU_03490" /old_locus_tag="BSU03490" /label="srfAB gene" CDS 372447..372587 /gene="comS" /locus_tag="BSU_03500" /old_locus_tag="BSU03500" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10361283, 16554821, 8752331, 9696775, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10361283, 16554821, 8752331, 9696775, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of genetic competence" /protein_id="NP_388232.1" /db_xref="EnsemblGenomes-Gn:BSU03500" /db_xref="EnsemblGenomes-Tr:CAB12144" /db_xref="GOA:P80355" /db_xref="InterPro:IPR035139" /db_xref="SubtiList:BG11045" /db_xref="UniProtKB/Swiss-Prot:P80355" /translation="MNRSGKHLISSIILYPRPSGECISSISLDKQTQATTSPLYFCWR EK*" /label="comS CDS" gene 372447..372587 /gene="comS" /locus_tag="BSU_03500" /old_locus_tag="BSU03500" /label="comS gene" CDS 380099..383926 /gene="srfAC" /locus_tag="BSU_03510" /old_locus_tag="BSU03510" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15066026, 16166527, 16553878, 17227471, 14762003, 22720735, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15066026, 16166527, 16553878, 17227471, 14762003, 22720735, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="surfactin synthetase" /protein_id="NP_388233.2" /db_xref="EnsemblGenomes-Gn:BSU03510" /db_xref="EnsemblGenomes-Tr:CAB12145" /db_xref="GOA:Q08787" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR001031" /db_xref="InterPro:IPR001242" /db_xref="InterPro:IPR006162" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR010071" /db_xref="InterPro:IPR020806" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="InterPro:IPR029058" /db_xref="InterPro:IPR036736" /db_xref="PDB:1JMK" /db_xref="PDB:2VSQ" /db_xref="SubtiList:BG10170" /db_xref="UniProtKB/Swiss-Prot:Q08787" /translation="MSQFSKDQVQDMYYLSPMQEGMLFHAILNPGQSFYLEQITMKVK GSLNIKCLEESMNVIMDRYDVFRTVFIHEKVKRPVQVVLKKRQFHIEEIDLTHLTGSE QTAKINEYKEQDKIRGFDLTRDIPMRAAIFKKAEESFEWVWSYHHIILDGWCFGIVVQ DLFKVYNALREQKPYSLPPVKPYKDYIKWLEKQDKQASLRYWREYLEGFEGQTTFAEQ RKKQKDGYEPKELLFSLSEAETKAFTELAKSQHTTLSTALQAVWSVLISRYQQSGDLA FGTVVSGRPAEIKGVEHMVGLFINVVPRRVKLSEGITFNGLLKRLQEQSLQSEPHQYV PLYDIQSQADQPKLIDHIIVFENYPLQDAKNEESSENGFDMVDVHVFEKSNYDLNLMA SPGDEMLIKLAYNENVFDEAFILRLKSQLLTAIQQLIQNPDQPVSTINLVDDREREFL LTGLNPPAQAHETKPLTYWFKEAVNANPDAPALTYSGQTLSYRELDEEANRIARRLQK HGAGKGSVVALYTKRSLELVIGILGVLKAGAAYLPVDPKLPEDRISYMLADSAAACLL THQEMKEQAAELPYTGTTLFIDDQTRFEEQASDPATAIDPNDPAYIMYTSGTTGKPKG NITTHANIQGLVKHVDYMAFSDQDTFLSVSNYAFDAFTFDFYASMLNAARLIIADEHT LLDTERLTDLILQENVNVMFATTALFNLLTDAGEDWMKGLRCILFGGERASVPHVRKA LRIMGPGKLINCYGPTEGTVFATAHVVHDLPDSISSLPIGKPISNASVYILNEQSQLQ PFGAVGELCISGMGVSKGYVNRADLTKEKFIENPFKPGETLYRTGDLARWLPDGTIEY AGRIDDQVKIRGHRIELEEIEKQLQEYPGVKDAVVVADRHESGDASINAYLVNRTQLS AEDVKAHLKKQLPAYMVPQTFTFLDELPLTTNGKVNKRLLPKPDQDQLAEEWIGPRNE MEETIAQIWSEVLGRKQIGIHDDFFALGGHSLKAMTAASRIKKELGIDLPVKLLFEAP TIAGISAYLKNGGSDGLQDVTIMNQDQEQIIFAFPPVLGYGLMYQNLSSRLPSYKLCA FDFIEEEDRLDRYADLIQKLQPEGPLTLFGYSAGCSLAFEAAKKLEEQGRIVQRIIMV DSYKKQGVSDLDGRTVESDVEALMNVNRDNEALNSEAVKHGLKQKTHAFYSYYVNLIS TGQVKADIDLLTSGADFDMPEWLASWEEATTGVYRVKRGFGTHAEMLQGETLDRNAEI LLEFLNTQTVTVS*" /label="srfAC CDS" gene 380099..383926 /gene="srfAC" /locus_tag="BSU_03510" /old_locus_tag="BSU03510" /label="srfAC gene" CDS 383955..384683 /gene="srfAD" /locus_tag="BSU_03520" /old_locus_tag="BSU03520" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:16166527, 16553878, 17227471, 14762003, 22720735, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16166527, 16553878, 17227471, 14762003, 22720735, 26284661; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="surfactin synthetase" /protein_id="NP_388234.1" /db_xref="EnsemblGenomes-Gn:BSU03520" /db_xref="EnsemblGenomes-Tr:CAB12146" /db_xref="GOA:Q08788" /db_xref="InterPro:IPR001031" /db_xref="InterPro:IPR012223" /db_xref="InterPro:IPR029058" /db_xref="PDB:2K2Q" /db_xref="PDB:2RON" /db_xref="SubtiList:BG10171" /db_xref="UniProtKB/Swiss-Prot:Q08788" /translation="MSQLFKSFDASEKTQLICFPFAGGYSASFRPLHAFLQGECEMLA AEPPGHGTNQTSAIEDLEELTDLYKQELNLRPDRPFVLFGHSMGGMITFRLAQKLERE GIFPQAVIISAIQPPHIQRKKVSHLPDDQFLDHIIQLGGMPAELVENKEVMSFFLPSF RSDYRALEQFELYDLAQIQSPVHVFNGLDDKKCIRDAEGWKKWAKDITFHQFDGGHMF LLSQTEEVAERIFAILNQHPIIQP*" /label="srfAD CDS" gene 383955..384683 /gene="srfAD" /locus_tag="BSU_03520" /old_locus_tag="BSU03520" /label="srfAD gene" downshifts 384665 /Source="Nicolas_upshifts" /id="D154" /incds=0 /nref=196 /ntot=261 /MaxReadThrough="4.65721" /MaxDrop="6.48992" /score="24.9581454" /energy="-11.1" /TU="U268" /idTUdmin="U268" /TUdmin="-1339" /isTUend="FALSE" /label="downshifts" promotor_-35 384721..384728 /Source="Nicolas_upshift_promotors" /id="U269" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.795204795204795" /psig=1 /xcortree=2955 /SigmaFactorBS="cattcaaccgtgatcaaaagcggacagcttcggctgttccgc tttttttgTGTTGAATgccaatttctgCATGGTATAATAGTCGAAATactcaaataaa g" /listShort="ycxA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 384731 /Source="Nicolas_upshifts" /id="U269" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.795204795204795" /psig=1 /xcortree=2955 /SigmaFactorBS="cattcaaccgtgatcaaaagcggacagcttcggctgttccgc tttttttgTGTTGAATgccaatttctgCATGGTATAATAGTCGAAATactcaaataaa g" /listShort="ycxA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 384740..384759 /Source="Nicolas_upshift_promotors" /id="U269" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.795204795204795" /psig=1 /xcortree=2955 /SigmaFactorBS="cattcaaccgtgatcaaaagcggacagcttcggctgttccgc tttttttgTGTTGAATgccaatttctgCATGGTATAATAGTCGAAATactcaaataaa g" /listShort="ycxA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 384784..386010 /gene="srfT" /locus_tag="BSU_03530" /old_locus_tag="BSU03530" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 15849754, 16850406, 25366377; Product type t: transporter" /codon_start=1 /transl_table=11 /product="surfactin exporter" /protein_id="NP_388235.2" /db_xref="EnsemblGenomes-Gn:BSU03530" /db_xref="EnsemblGenomes-Tr:CAB12147" /db_xref="GOA:Q08791" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10172" /db_xref="UniProtKB/Swiss-Prot:Q08791" /translation="MRTSPRMKWFVLLFTFVFAIGMNSFRNSFQFFMLPMADAFHADR SLISVSVSIFMITTGIVQFFVGFFIDRFSVRKIMALGAVCISASFLVLPYSPNVHVFS AIYGVLGGIGYSCAVGVTTQYFISCWFDTHKGLALAILTNANSAGLLLLSPIWAAAPY HAGWQSTYTILGIVMAAVLLPLLVFGMKHPPHAQAETVKKSYDWRGFWNVMKQSRLIH ILYFGVFTCGFTMGIIDAHLVPILKDAHVSHVNGMMAAFGAFIIIGGLLAGWLSDLLG SRSVMLSILFFIRLLSLICLLIPILGIHHSDLWYFGFILLFGLSYTGVIPLTAASISE SYQTGLIGSLLGINFFIHQVAGALSVYAGGLFFDMTHGYLLIVAVCIVFVGLSAVIEL VPFLDKQKAKETHHSI*" /label="srfT CDS" gene 384784..386010 /gene="srfT" /locus_tag="BSU_03530" /old_locus_tag="BSU03530" /label="srfT gene" downshifts 386004 /Source="Nicolas_upshifts" /id="D155" /incds=0 /nref=15 /ntot=198 /MaxReadThrough="2.67601" /MaxDrop="4.06773" /score="7.33278866" /energy="-13.2" /TU="NA" /idTUdmin="U268" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(386025..386582) /gene="ycxB" /locus_tag="BSU_03540" /old_locus_tag="BSU03540" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 21965396" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_388236.1" /db_xref="EnsemblGenomes-Gn:BSU03540" /db_xref="EnsemblGenomes-Tr:CAB12148" /db_xref="GOA:Q08793" /db_xref="InterPro:IPR025588" /db_xref="SubtiList:BG10173" /db_xref="UniProtKB/Swiss-Prot:Q08793" /translation="MIQYASESINLPGEITFKDVREIFFYQIAKISCFYFLLFCAIFA AVNFINGWPRIVYGSDALNLFMNSMLIIVMSVLFTLLLLLLLYVKFSRAYKKNERMKS KRTYTLNQEGIRICSKKYDLIFNWDEITAVFEYKNIFRVNTSSGQYIAIPKHFFHSEE EMNRFKEIILKNTETKKLKFKKDQH*" /label="ycxB CDS" gene complement(386025..386582) /gene="ycxB" /locus_tag="BSU_03540" /old_locus_tag="BSU03540" /label="ycxB gene" promotor_no_box complement(386040..386140) /Source="Nicolas_upshift_promotors" /id="U270" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.725274725274725" /psig="0.024975024975025" /xcortree=283 /SigmaFactorBS="atattgcgatccccaaacatttttttcactccgaagaggaga tgaacagattcaaggagattatccttaaaaataccgaaacaaaaaaactcaaatttaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" downshifts complement(386062) /Source="Nicolas_upshifts" /id="D156" /incds=0 /nref=46 /ntot=241 /MaxReadThrough="0.9216" /MaxDrop="4.25654" /score="8.42655219" /energy="-14.3" /TU="U270" /idTUdmin="U271" /TUdmin=18 /isTUend="TRUE" /label="downshifts" upshifts complement(386080) /Source="Nicolas_upshifts" /id="U270" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.725274725274725" /psig="0.024975024975025" /xcortree=283 /SigmaFactorBS="atattgcgatccccaaacatttttttcactccgaagaggaga tgaacagattcaaggagattatccttaaaaataccgaaacaaaaaaactcaaatttaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(386611..386630) /Source="Nicolas_upshift_promotors" /id="U271" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.942057942057942" /psig=1 /xcortree=3105 /SigmaFactorBS="aaaaaacaaagcgccctggtatgcctgcaaaaaaatgagaaa tTATGCTAGACTAAAAGGAAAaacatggttagaggtgtaggtttaccgtatgattcaa t" /listShort="ycxB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(386613) /Source="Nicolas_upshifts" /id="U271" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.942057942057942" /psig=1 /xcortree=3105 /SigmaFactorBS="aaaaaacaaagcgccctggtatgcctgcaaaaaaatgagaaa tTATGCTAGACTAAAAGGAAAaacatggttagaggtgtaggtttaccgtatgattcaa t" /listShort="ycxB" /GFF_Attribute="listLong" /label="upshifts" CDS complement(386636..387574) /gene="ycxC" /locus_tag="BSU_03550" /old_locus_tag="BSU03550" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388237.2" /db_xref="EnsemblGenomes-Gn:BSU03550" /db_xref="EnsemblGenomes-Tr:CAB12149" /db_xref="GOA:Q08794" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG10174" /db_xref="UniProtKB/Swiss-Prot:Q08794" /translation="MVKHQQTPAYIAAILYSFIIGLSFLFVKIALQTAEPFDILAHRF TIAFAAATVPILFGWVKLSIRVKDVIDILPLALLYPALFFSFQAFGLVYSSSSEAGII QAAIPIFTMVFAAYVLKERPTWTQKGFTVLSVAGVMFIFVMKGVDVESASLKGSLLIL LSALSSAMYNTAARKMTQRFKLTELTYIMSAIGFVVFNAIALVRHGAAGTVGTYFLPF REPGFVLAIVYLGVLSSLVTSFLSNYTLSRIEAFKMSAFNHVSTIVTMIAGFVILNES LAWYHLAGAVCIMIGVVGSNINLEKKTKRPGMPAKK*" /label="ycxC CDS" gene complement(386636..387574) /gene="ycxC" /locus_tag="BSU_03550" /old_locus_tag="BSU03550" /label="ycxC gene" promotor_-10 complement(387613..387631) /Source="Nicolas_upshift_promotors" /id="U272" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.536463536463537" /psig="0.536463536463537" /xcortree=793 /SigmaFactorBS="tgtaccggtacagttcattgtttttctcATTGTAccgttctg accgcggCCATACAATAAAGGGAGCGaccggcgctgcaattcaggtaaaggagccctt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(387620) /Source="Nicolas_upshifts" /id="U272" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.536463536463537" /psig="0.536463536463537" /xcortree=793 /SigmaFactorBS="tgtaccggtacagttcattgtttttctcATTGTAccgttctg accgcggCCATACAATAAAGGGAGCGaccggcgctgcaattcaggtaaaggagccctt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(387647..387652) /Source="Nicolas_upshift_promotors" /id="U272" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.536463536463537" /psig="0.536463536463537" /xcortree=793 /SigmaFactorBS="tgtaccggtacagttcattgtttttctcATTGTAccgttctg accgcggCCATACAATAAAGGGAGCGaccggcgctgcaattcaggtaaaggagccctt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 387698..389032 /gene="ycxD" /locus_tag="BSU_03560" /old_locus_tag="BSU03560" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15223311, 26585522; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative PLP-dependent transcriptional regulator" /protein_id="NP_388238.1" /db_xref="EnsemblGenomes-Gn:BSU03560" /db_xref="EnsemblGenomes-Tr:CAB12150" /db_xref="GOA:Q08792" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10175" /db_xref="UniProtKB/Swiss-Prot:Q08792" /translation="MEKYMSLLTRIEEMMQSTSYQEGDRLPSIRQLSARYQVSKSTVI RALQELEKRHLIYSVPKSGYYIVKKSGKSKSGQPGPIDFATSAPDPDVFPYLDFQHCI NKAIDTYKNDLFIYGTPKGLPSLIRVLRKLLATQQVFADERHIFITSGVQQALSLLCA MPFPNGKEKIAIEQPGYHLMVEQLETLGIPAIGVKRTEEGLDIAKVERLFQTESIKFF YTMPRFHNPLGCSLSERDKQELVRLAEAYDVYLVEDDYLGDLEENKKADPLYAYDLSS HVIYLKSFSKMMFPGLRVGAAVLPEALTDTFYAYKKLNDIDCSMISQAALEIYLKSGM YGRHKEKIRDSYKERSLRLHQAIRTHRQLGSGRFTFSSGQAPCMHTHLVLPQDLPASR VIHRLEKQGVLLEAIDRHYLSDYPKENLLKINISNVKTEDIERGVKLLMSHL*" /label="ycxD CDS" gene 387698..389032 /gene="ycxD" /locus_tag="BSU_03560" /old_locus_tag="BSU03560" /label="ycxD gene" CDS complement(389027..389194) /gene="sfpAc" /locus_tag="BSU_03569" /old_locus_tag="BSU03569" /EC_number="2.7.8.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 10568751, 17376553, 2848009, 9384377, 14762003, 16707694, 19061923, 20971906, 25288929, 26268540; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="C-terminal part of 4'-phosphopantetheinyl transferase (Surfactin synthetase-activating enzyme)" /db_xref="PSEUDO:CAX52545.1" /translation="MRLHQDGQVSIELPDSHSPCYIKTYEVDPGYKMAVCAVHPDFPE DITMVSYEELL*" /label="sfpAc CDS" gene complement(389027..389194) /gene="sfpAc" /locus_tag="BSU_03569" /old_locus_tag="BSU03569" /pseudo /label="sfpAc gene" CDS complement(389205..389702) /gene="sfpAn" /locus_tag="BSU_03570" /old_locus_tag="BSU03570" /EC_number="2.7.8.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 10568751, 17376553, 2848009, 9384377, 14762003, 16707694, 19061923, 20971906, 25288929, 26268540; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="N-terminal part of 4'-phosphopantetheinyl transferase (surfactin synthetase-activating enzyme)" /db_xref="GOA:P39135" /db_xref="InterPro:IPR004568" /db_xref="InterPro:IPR008278" /db_xref="InterPro:IPR037143" /db_xref="PDB:1QR0" /db_xref="PDB:2GE0" /db_xref="PDB:2GE1" /db_xref="PDB:4MRT" /db_xref="PSEUDO:CAB12151.2" /db_xref="SubtiList:BG10176" /db_xref="UniProtKB/Swiss-Prot:P39135" /translation="MKIYGIYMDRPLSQEENERFMSFISPEKREKCRRFYHKEDAHRT LLGDVLVRSVISRQYQLDKSDIRFSTQEYGKPCIPDLPDAHFNISHSGRWVICAFDSQ PIGIDIEKTKPISLEIAKRFFSKTEYSDLLAKDKDEQTDYFYHLWSMKESFIKQGRQR LIASA*" /label="sfpAn CDS" gene complement(389205..389702) /gene="sfpAn" /locus_tag="BSU_03570" /old_locus_tag="BSU03570" /pseudo /label="sfpAn gene" misc_feature complement(389729..389748) /Source="Nicolas_upshift_promotors" /id="U273" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2243 /SigmaFactorBS="agccgccttggctttgtttttttattttctcctctatatgag tcttgtggaagTATGATAGGATGGTTTTGACaatcttttgcagacggaggatctagaa t" /listShort="sfp, sfp" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(389741) /Source="Nicolas_upshifts" /id="U273" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2243 /SigmaFactorBS="agccgccttggctttgtttttttattttctcctctatatgag tcttgtggaagTATGATAGGATGGTTTTGACaatcttttgcagacggaggatctagaa t" /listShort="sfp, sfp" /GFF_Attribute="listLong" /label="upshifts" CDS complement(389807..390454) /gene="yczE" /locus_tag="BSU_03580" /old_locus_tag="BSU03580" /function="15.11: Biosynthesis of natural products" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16850406, 17827323, 14762003, 16707694, 17827323, 25288929; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="integral inner membrane protein regulating antibiotic production" /protein_id="NP_388240.2" /db_xref="EnsemblGenomes-Gn:BSU03580" /db_xref="EnsemblGenomes-Tr:CAB12152" /db_xref="GOA:O34927" /db_xref="SubtiList:BG12779" /db_xref="UniProtKB/Swiss-Prot:O34927" /translation="MKQELVLRWTFYFAGLIILAFGVSLTIEGKALGISPWDAFHYSL FQHFGLTVGQWSIIIGALIVGFTSLFTRAWPKIGALLNMVLIGVFIDFFNFILPALST YTGSIIVFSLGVVLIGYGVGVYVSAGLGAGPRDSLMMLITEKTGWNVQWVRNGMELTI LFAAWGMGGPIGFGTILTAILTGLILRFSLPQSIQLLNYAVARRTAAVKASPPVH*" /label="yczE CDS" gene complement(389807..390454) /gene="yczE" /locus_tag="BSU_03580" /old_locus_tag="BSU03580" /label="yczE gene" promotor_-10 complement(390483..390502) /Source="Nicolas_upshift_promotors" /id="U274" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.866133866133866" /psig=1 /xcortree=2616 /SigmaFactorBS="tttttttgttgagcccctttcgccTATTCcgcccttctgtca gaTGTGCTACAATGACAATCGActgatttttacgaaagaagggacctcacgtgaagca a" /listShort="yczE, sfp, sfp" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(390486) /Source="Nicolas_upshifts" /id="U274" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.866133866133866" /psig=1 /xcortree=2616 /SigmaFactorBS="tttttttgttgagcccctttcgccTATTCcgcccttctgtca gaTGTGCTACAATGACAATCGActgatttttacgaaagaagggacctcacgtgaagca a" /listShort="yczE, sfp, sfp" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(390518..390522) /Source="Nicolas_upshift_promotors" /id="U274" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.866133866133866" /psig=1 /xcortree=2616 /SigmaFactorBS="tttttttgttgagcccctttcgccTATTCcgcccttctgtca gaTGTGCTACAATGACAATCGActgatttttacgaaagaagggacctcacgtgaagca a" /listShort="yczE, sfp, sfp" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(390623..390774) /Source="Nicolas_S_feature" /locus_tag="new_409056_409207_c" /HighExp="G180, G135, dia15, H2O2, Diami, S8, Oxctl, G150, LPhT, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S127" CDS complement(390775..391518) /gene="tcyC" /locus_tag="BSU_03590" /old_locus_tag="BSU03590" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15262924, 16513748, 22212096" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15262924, 16513748, 22212096; Product type t: transporter" /codon_start=1 /transl_table=11 /product="cystine ABC transporter (ATP-binding protein)" /protein_id="NP_388241.2" /db_xref="EnsemblGenomes-Gn:BSU03590" /db_xref="EnsemblGenomes-Tr:CAB12153" /db_xref="GOA:P39456" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030679" /db_xref="SubtiList:BG11185" /db_xref="UniProtKB/Swiss-Prot:P39456" /translation="MLTVKGLNKSFGENEILKKIDMKIEKGKVIAILGPSGSGKTTLL RCLNALEIPNRGELAFDDFSIDFSKKVKQADILKLRRKSGMVFQAYHLFPHRTALENV MEGPVQVQKRNKEEVRKEAIQLLDKVGLKDKMDLYPFQLSGGQQQRVGIARALAIQPE LMLFDEPTSALDPELVGEVLKVIKDLANEGWTMVVVTHEIKFAQEVADEVIFIDGGVI VEQGPPEQIFSAPKEERTQRFLNRILNPL*" /label="tcyC CDS" gene complement(390775..391518) /gene="tcyC" /locus_tag="BSU_03590" /old_locus_tag="BSU03590" /label="tcyC gene" downshifts complement(390831) /Source="Nicolas_upshifts" /id="D157" /incds=0 /nref=72 /ntot=232 /MaxReadThrough="4.60958" /MaxDrop="4.44283" /score="1.62131565" /energy="-12.6" /TU="U275" /idTUdmin="U276" /TUdmin=4 /isTUend="TRUE" /label="downshifts" CDS complement(391532..392236) /gene="tcyB" /locus_tag="BSU_03600" /old_locus_tag="BSU03600" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15262924, 15849754, 16850406, 22212096" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15262924, 15849754, 16850406, 22212096; Product type t: transporter" /codon_start=1 /transl_table=11 /product="cystine ABC transporter (permease)" /protein_id="NP_388242.1" /db_xref="EnsemblGenomes-Gn:BSU03600" /db_xref="EnsemblGenomes-Tr:CAB12154" /db_xref="GOA:P42200" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR010065" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11186" /db_xref="UniProtKB/Swiss-Prot:P42200" /translation="MFLNNLPALTLGTAIPWDLVQQSFWPILSGGIYYTIPLTILSFI FGMILALITALARMSKVRPLRWVFSVYVSAIRGTPLLVQLFIIFYLFPAFNVTLDPFP SAVIAFSLNVGAYASEIIRASILSVPKGQWEAGYTIGMTHQKTLFRVILPQAFRVSIP PLSNTFISLIKDTSLASQILVAELFRKAQEIGARNLDQILVIYIEAAFIYWIICFLLS LVQHVIERRLDRYVAK*" /label="tcyB CDS" gene complement(391532..392236) /gene="tcyB" /locus_tag="BSU_03600" /old_locus_tag="BSU03600" /label="tcyB gene" CDS complement(392223..393029) /gene="tcyA" /locus_tag="BSU_03610" /old_locus_tag="BSU03610" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15262924, 22212096" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15262924, 22212096; Product type t: transporter" /codon_start=1 /transl_table=11 /product="cystine ABC transporter (substrate-binding lipoprotein)" /protein_id="NP_388243.2" /db_xref="EnsemblGenomes-Gn:BSU03610" /db_xref="EnsemblGenomes-Tr:CAB12155" /db_xref="GOA:P42199" /db_xref="InterPro:IPR001638" /db_xref="InterPro:IPR018313" /db_xref="SubtiList:BG11187" /db_xref="UniProtKB/Swiss-Prot:P42199" /translation="MKKALLALFMVVSIAALAACGAGNDNQSKDNAKDGDLWASIKKK GVLTVGTEGTYEPFTYHDKDTDKLTGYDVEVITEVAKRLGLKVDFKETQWDSMFAGLN SKRFDVVANQVGKTDREDKYDFSDKYTTSRAVVVTKKDNNDIKSEADVKGKTSAQSLT SNYNKLATNAGAKVEGVEGMAQALQMIQQGRVDMTYNDKLAVLNYLKTSGNKNVKIAF ETGEPQSTYFTFRKGSGEVVDQVNKALKEMKEDGTLSKISKKWFGEDVSK*" /label="tcyA CDS" gene complement(392223..393029) /gene="tcyA" /locus_tag="BSU_03610" /old_locus_tag="BSU03610" /label="tcyA gene" promotor_-10 complement(393078..393097) /Source="Nicolas_upshift_promotors" /id="U275" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.913086913086913" /psig="0.987012987012987" /xcortree=1798 /SigmaFactorBS="ttttaaaagattttgtcttatgaaaaccaaatACTTGACTca tactaaaaaaaAGTTATCCTTTAGATTTGTAagctaattttttatttcaataaaatca a" /listShort="tcyA, tcyB, tcyC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(393090) /Source="Nicolas_upshifts" /id="U275" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.913086913086913" /psig="0.987012987012987" /xcortree=1798 /SigmaFactorBS="ttttaaaagattttgtcttatgaaaaccaaatACTTGACTca tactaaaaaaaAGTTATCCTTTAGATTTGTAagctaattttttatttcaataaaatca a" /listShort="tcyA, tcyB, tcyC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(393111..393118) /Source="Nicolas_upshift_promotors" /id="U275" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.913086913086913" /psig="0.987012987012987" /xcortree=1798 /SigmaFactorBS="ttttaaaagattttgtcttatgaaaaccaaatACTTGACTca tactaaaaaaaAGTTATCCTTTAGATTTGTAagctaattttttatttcaataaaatca a" /listShort="tcyA, tcyB, tcyC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(393145..394017) /gene="bsdA" /locus_tag="BSU_03620" /old_locus_tag="BSU03620" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17295427" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17295427; Product type r: regulator" /codon_start=1 /transl_table=11 /product="HTH-type transcriptional regulator BsdA (LysR family)" /protein_id="NP_388244.1" /db_xref="EnsemblGenomes-Gn:BSU03620" /db_xref="EnsemblGenomes-Tr:CAB12156" /db_xref="GOA:P94403" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12022" /db_xref="UniProtKB/Swiss-Prot:P94403" /translation="MDIRQLRYFITIAQEQKITSAAKKLHMAQPPLSRQLKQLEDELG VVLFDRNKKKQMTLTYEGAVFLKRAKEILHRFEDAVIEVQELKEEVAGTLAVGSTIYC AALMLEKVTQIKERYPHLTFNIWENEPATLLELLESRQIDAAVTTTLIKSDTVQFKQL DDIPCVLVLSDEAGYPCGDTIKMVDIPSFPLILLRPVNGKGVYNQVMNEFHRLNLEPR IVCECHDSATLLSLVSSGFGASILPVTMIPVHMRNHVHTVHIENNPFIMTPAVMWRTD SYLPKPAQQFLDLF*" /label="bsdA CDS" gene complement(393145..394017) /gene="bsdA" /locus_tag="BSU_03620" /old_locus_tag="BSU03620" /label="bsdA gene" promotor_-10 complement(393755..393773) /Source="Nicolas_upshift_promotors" /id="U276" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=148 /SigmaFactorBS="ctaaaaagagcaaaagagattctgcataGGTTTGAagatgca gtcattgAGGTACAGGAGCTGAAGGAggaagtagccggtacacttgccgtgggatcaa c" /listShort="tcyA, tcyB, tcyC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(393762) /Source="Nicolas_upshifts" /id="U276" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=148 /SigmaFactorBS="ctaaaaagagcaaaagagattctgcataGGTTTGAagatgca gtcattgAGGTACAGGAGCTGAAGGAggaagtagccggtacacttgccgtgggatcaa c" /listShort="tcyA, tcyB, tcyC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(393788..393794) /Source="Nicolas_upshift_promotors" /id="U276" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=148 /SigmaFactorBS="ctaaaaagagcaaaagagattctgcataGGTTTGAagatgca gtcattgAGGTACAGGAGCTGAAGGAggaagtagccggtacacttgccgtgggatcaa c" /listShort="tcyA, tcyB, tcyC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 394071..394078 /Source="Nicolas_upshift_promotors" /id="U278" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.947052947052947" /psig="0.97902097902098" /xcortree=1580 /SigmaFactorBS="ccttttaggtattaattatagatttaatagaTATTTTTCata tggatatatcAGGAGTATGATTGAAATGAAagcagaattcaagcgtaaaggagggggc a" /listShort="ubiX, ubiD, bsdD, yclD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(394086..394105) /Source="Nicolas_upshift_promotors" /id="U277" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.978021978021978" /psig="0.985014985014985" /xcortree=1966 /SigmaFactorBS="cgagtttcactttgccccctcctttaCGCTTGAAttctgctt tcattTCAATCATACTCCTGATATAtccatatgaaaaatatctattaaatctataatt a" /listShort="yclA" /listLong="tcyA, tcyB, tcyC" /label="promotor_-10" promotor_-10 394092..394111 /Source="Nicolas_upshift_promotors" /id="U278" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.947052947052947" /psig="0.97902097902098" /xcortree=1580 /SigmaFactorBS="ccttttaggtattaattatagatttaatagaTATTTTTCata tggatatatcAGGAGTATGATTGAAATGAAagcagaattcaagcgtaaaggagggggc a" /listShort="ubiX, ubiD, bsdD, yclD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(394092) /Source="Nicolas_upshifts" /id="U277" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.978021978021978" /psig="0.985014985014985" /xcortree=1966 /SigmaFactorBS="cgagtttcactttgccccctcctttaCGCTTGAAttctgctt tcattTCAATCATACTCCTGATATAtccatatgaaaaatatctattaaatctataatt a" /listShort="yclA" /listLong="tcyA, tcyB, tcyC" /label="upshifts" upshifts 394100 /Source="Nicolas_upshifts" /id="U278" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.947052947052947" /psig="0.97902097902098" /xcortree=1580 /SigmaFactorBS="ccttttaggtattaattatagatttaatagaTATTTTTCata tggatatatcAGGAGTATGATTGAAATGAAagcagaattcaagcgtaaaggagggggc a" /listShort="ubiX, ubiD, bsdD, yclD" /GFF_Attribute="listLong" /label="upshifts" CDS 394107..394721 /gene="ubiX" /locus_tag="BSU_03630" /old_locus_tag="BSU03630" /EC_number="4.1.1.-" /EC_number="4.1.1.61" /function="3.2: Degradation" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 10919793, 15979273, 17295427, 18388975, 26083743, 26658822, 26337367; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phenolic acid decarboxylase-flavin prenyltransferase subunit" /protein_id="NP_388245.1" /db_xref="EnsemblGenomes-Gn:BSU03630" /db_xref="EnsemblGenomes-Tr:CAB12157" /db_xref="GOA:P94404" /db_xref="InterPro:IPR003382" /db_xref="InterPro:IPR004507" /db_xref="InterPro:IPR032901" /db_xref="InterPro:IPR036551" /db_xref="SubtiList:BG12023" /db_xref="UniProtKB/Swiss-Prot:P94404" /translation="MKAEFKRKGGGKVKLVVGMTGATGAIFGVRLLQWLKAAGVETHL VVSPWANVTIKHETGYTLQEVEQLATYTYSHKDQAAAISSGSFDTDGMIVAPCSMKSL ASIRTGMADNLLTRAADVMLKERKKLVLLTRETPLNQIHLENMLALTKMGTIILPPMP AFYNRPRSLEEMVDHIVFRTLDQFGIRLPEAKRWNGIEKQKGGA*" /label="ubiX CDS" gene 394107..394721 /gene="ubiX" /locus_tag="BSU_03630" /old_locus_tag="BSU03630" /label="ubiX gene" promotor_-35 complement(394119..394126) /Source="Nicolas_upshift_promotors" /id="U277" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.978021978021978" /psig="0.985014985014985" /xcortree=1966 /SigmaFactorBS="cgagtttcactttgccccctcctttaCGCTTGAAttctgctt tcattTCAATCATACTCCTGATATAtccatatgaaaaatatctattaaatctataatt a" /listShort="yclA" /listLong="tcyA, tcyB, tcyC" /label="promotor_-35" CDS 394724..396145 /gene="bsdC" /locus_tag="BSU_03640" /old_locus_tag="BSU03640" /EC_number="4.1.1.61" /EC_number="4.1.1.-" /function="3.2: Degradation" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 11029449, 15979273, 17295427, 18388975, 26658822, 26337367; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="promiscuous phenolic acid decarboxylase subunit;1,4-dihydroxy-2-naphtoate-heptaprenyl diphosphatedecarboxylase" /protein_id="NP_388246.1" /db_xref="EnsemblGenomes-Gn:BSU03640" /db_xref="EnsemblGenomes-Tr:CAB12158" /db_xref="GOA:P94405" /db_xref="InterPro:IPR002830" /db_xref="InterPro:IPR012349" /db_xref="InterPro:IPR032902" /db_xref="SubtiList:BG12024" /db_xref="UniProtKB/Swiss-Prot:P94405" /translation="MAYQDFREFLAALEKEGQLLTVNEEVKPEPDLGASARAASNLGD KSPALLFNNIYGYHNARIAMNVIGSWPNHAMMLGMPKDTPVKEQFFEFAKRYDQFPMP VKREETAPFHENEITEDINLFDILPLFRINQGDGGYYLDKACVISRDLEDPDNFGKQN VGIYRMQVKGKDRLGIQPVPQHDIAIHLRQAEERGINLPVTIALGCEPVITTAASTPL LYDQSEYEMAGAIQGEPYRIVKSKLSDLDVPWGAEVVLEGEIIAGEREYEGPFGEFTG HYSGGRSMPIIKIKRVYHRNNPIFEHLYLGMPWTECDYMIGINTCVPLYQQLKEAYPN EIVAVNAMYTHGLIAIVSTKTRYGGFAKAVGMRALTTPHGLGYCKMVIVVDEDVDPFN LPQVMWALSTKMHPKHDAVIIPDLSVLPLDPGSNPSGITHKMILDATTPVAPETRGHY SQPLDSPLTTKEWEQKLMDLMNK*" /label="bsdC CDS" gene 394724..396145 /gene="bsdC" /locus_tag="BSU_03640" /old_locus_tag="BSU03640" /label="bsdC gene" CDS 396162..396389 /gene="bsdD" /locus_tag="BSU_03651" /old_locus_tag="BSU03651" /EC_number="4.1.1.91" /EC_number="4.1.1.-" /EC_number="4.1.1.61" /function="3.2: Degradation" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 15979273, 17295427, 18388975, 26658822; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phenolic acid decarboxylase subunit" /protein_id="YP_003097675.1" /db_xref="EnsemblGenomes-Gn:BSU03651" /db_xref="EnsemblGenomes-Tr:CAX52546" /db_xref="GOA:C0H3U9" /db_xref="UniProtKB/Swiss-Prot:C0H3U9" /translation="MHTCPRCDSKKGEVMSKSPVEGAWEVYQCQTCFFTWRSCEPESI TNPEKYNPAFKIDPKETETAIEVPAVPERKA*" /label="bsdD CDS" gene 396162..396389 /gene="bsdD" /locus_tag="BSU_03651" /old_locus_tag="BSU03651" /label="bsdD gene" CDS 396386..396850 /gene="yclD" /locus_tag="BSU_03652" /old_locus_tag="BSU03652" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15979273, 18388975; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative FMN-binding enzyme subunit" /protein_id="NP_388247.2" /db_xref="EnsemblGenomes-Gn:BSU03652" /db_xref="EnsemblGenomes-Tr:CAB12159" /db_xref="GOA:C0SPB5" /db_xref="InterPro:IPR012349" /db_xref="SubtiList:BG12025" /db_xref="UniProtKB/Swiss-Prot:C0SPB5" /translation="MIRVNCMSDRLFELLDGSCLNEKQHEAFVLQTVSEDGWPHAAMI SAGEIIALSRTDIRIALWKNTMTSANILRTGKAQFTAWWKGAAYYVKLECAPLPPLKD AEYERDRFSCRIVSVKEDVAKYADLTSGVRIQLHSPEEVLSRWKKTLEDLKR*" /label="yclD CDS" gene 396386..396850 /gene="yclD" /locus_tag="BSU_03652" /old_locus_tag="BSU03652" /label="yclD gene" downshifts 396831 /Source="Nicolas_upshifts" /id="D158" /incds=0 /nref=1 /ntot=4 /MaxReadThrough="3.32586" /MaxDrop="3.88166" /score="45.8937489" /energy="-15.1" /TU="NA" /idTUdmin="U278" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature 396857..396858 /Source="Nicolas_upshift_promotors" /id="U279" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.357642357642358" /psig="0.557442557442557" /xcortree=3132 /SigmaFactorBS="ctgaagaggtgctgagcagatggaaaaagaccctggaagatt taaaacggtaatatcgaTAgcctgacgccatgcgtcaggctttttttatataatgaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 396858 /Source="Nicolas_upshifts" /id="U279" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.357642357642358" /psig="0.557442557442557" /xcortree=3132 /SigmaFactorBS="ctgaagaggtgctgagcagatggaaaaagaccctggaagatt taaaacggtaatatcgaTAgcctgacgccatgcgtcaggctttttttatataatgaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 396917..397762 /gene="yclE" /locus_tag="BSU_03660" /old_locus_tag="BSU03660" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_388248.2" /db_xref="EnsemblGenomes-Gn:BSU03660" /db_xref="EnsemblGenomes-Tr:CAB12160" /db_xref="GOA:P94407" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12026" /db_xref="UniProtKB/Swiss-Prot:P94407" /translation="MERAGICHSDGFDLAYRIEGEGAPILVIGSAVYYPRLFSSDIKQ KYQWVFVDHRGFAKPKRELRAEDSRLDAVLADIERMRTFLQLEDVTILGHSGHAFMAL EYARTYPKQVRKVALFNTAPDNSEERQRKSESFFMETASLERKKRFEKDIENLPQDID KDPERRFVHMCIRAEAKSFYQERPHAAALWDGVFTNMPIIDELWGNTFARIDLLQRLA DVRMPVYIGLGRYDYLVAPVSLWDAVDGLYPHVDKVIFEKSGHQPMLEEPEAFDQSFR KWLDQ*" /label="yclE CDS" gene 396917..397762 /gene="yclE" /locus_tag="BSU_03660" /old_locus_tag="BSU03660" /label="yclE gene" CDS complement(397802..399280) /gene="dtpT" /locus_tag="BSU_03670" /old_locus_tag="BSU03670" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8458848, 11717292, 15849754, 16204487, 16850406, 17496096, 23144141, 25966844; Product type t: transporter" /codon_start=1 /transl_table=11 /product="di-tripeptide-proton ABC symporter" /protein_id="NP_388249.2" /db_xref="EnsemblGenomes-Gn:BSU03670" /db_xref="EnsemblGenomes-Tr:CAB12175" /db_xref="GOA:P94408" /db_xref="InterPro:IPR000109" /db_xref="InterPro:IPR005279" /db_xref="InterPro:IPR018456" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12027" /db_xref="UniProtKB/Swiss-Prot:P94408" /translation="MASIDNESIIKSVPQKGFFGHPRGLFTLFFTEFWERFSYYGMRA ILLYYLYTETVNGGLGFDKGTAVAIMSIYGSLVYMSTIIGGWLADRVFGTANTVFYGG IFIMFGHIALAYPGSSIAFYISMVLIIVGTGLLKPNVSSVVGDLYTKEDPRRDSGFSI FYMGINLGGLLAPLIVGTLGQKYNYHLGFGAAAVGMLLGLIVFALTRKKNLGLAGSNV PNPLSKKSAIGTGIGVIIVAIAVIISVQTGVLTIKRFIDLVSILGILIPVIYFIIMFT SKKADKTEKSRLAAYVPLFIGAVMFWAIQEQGATILAVYADERIRLSLGGFELQSSWF QSLNPLFVVIFAPIFAWLWMKLGKRQPSTPVKFSIGIILAGLSFIIMVFPAMQGKEAL VSPLWLVLSFLLVVLGELCLSPVGLSVTTKLAPAAFSAQTMSMWFLTNAAAQAINAQV AGLFDKIPETMYFGTIGLISIVLGGILLLLSPVIKRAMKGVL*" /label="dtpT CDS" gene complement(397802..399280) /gene="dtpT" /locus_tag="BSU_03670" /old_locus_tag="BSU03670" /label="dtpT gene" downshifts complement(397810) /Source="Nicolas_upshifts" /id="D159" /incds=0 /nref=17 /ntot=90 /MaxReadThrough="1.40624" /MaxDrop="3.91827" /score="43.5753464" /energy="-21" /TU="NA" /idTUdmin="U281" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 399307..399309 /Source="Nicolas_upshift_promotors" /id="U280" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.257742257742258" /psig="0.581418581418581" /xcortree=1444 /SigmaFactorBS="ctttcgttatcaatcgaagccatgtcagccaaaccctttcta aaaaaagTGTattataaaaatcatatTCTTATATAATACTTGTGTcaatataatttat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(399308..399327) /Source="Nicolas_upshift_promotors" /id="U281" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.97002997002997" /xcortree=1442 /SigmaFactorBS="tttttccaatatggaactatttgaaatgagtataaattaTAT TGACAcaagtattatataaGAATATGATTTTTATAATACactttttttagaaagggtt t" /listShort="dtpT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 399318 /Source="Nicolas_upshifts" /id="U280" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.257742257742258" /psig="0.581418581418581" /xcortree=1444 /SigmaFactorBS="ctttcgttatcaatcgaagccatgtcagccaaaccctttcta aaaaaagTGTattataaaaatcatatTCTTATATAATACTTGTGTcaatataatttat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 399326..399344 /Source="Nicolas_upshift_promotors" /id="U280" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.257742257742258" /psig="0.581418581418581" /xcortree=1444 /SigmaFactorBS="ctttcgttatcaatcgaagccatgtcagccaaaccctttcta aaaaaagTGTattataaaaatcatatTCTTATATAATACTTGTGTcaatataatttat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(399328) /Source="Nicolas_upshifts" /id="U281" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.97002997002997" /xcortree=1442 /SigmaFactorBS="tttttccaatatggaactatttgaaatgagtataaattaTAT TGACAcaagtattatataaGAATATGATTTTTATAATACactttttttagaaagggtt t" /listShort="dtpT" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(399330..399834) /Source="Nicolas_S_feature" /locus_tag="new_417763_418267_c" /HighExp="S3, S4, LoTm, S5, S6, T5.0H, T4.0H, M9-stat, S8, T3.30H" /AntisenseName="yclG" /AntisenseCor="0.33937447534762299" /AntisenseRegPval="-7.9" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S128" promotor_-35 complement(399342..399349) /Source="Nicolas_upshift_promotors" /id="U281" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.97002997002997" /xcortree=1442 /SigmaFactorBS="tttttccaatatggaactatttgaaatgagtataaattaTAT TGACAcaagtattatataaGAATATGATTTTTATAATACactttttttagaaagggtt t" /listShort="dtpT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 399498..399507 /Source="Nicolas_upshift_promotors" /id="U282" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1425 /SigmaFactorBS="attcctttatatttttttaataaaattttagagaaatGTACA AGCAGatcgggcctttgTGAGTAACATGATAGTAATCatagagaaggaggctcgcaat t" /listShort="yclG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 399520..399539 /Source="Nicolas_upshift_promotors" /id="U282" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1425 /SigmaFactorBS="attcctttatatttttttaataaaattttagagaaatGTACA AGCAGatcgggcctttgTGAGTAACATGATAGTAATCatagagaaggaggctcgcaat t" /listShort="yclG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 399521 /Source="Nicolas_upshifts" /id="U282" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1425 /SigmaFactorBS="attcctttatatttttttaataaaattttagagaaatGTACA AGCAGatcgggcctttgTGAGTAACATGATAGTAATCatagagaaggaggctcgcaat t" /listShort="yclG" /GFF_Attribute="listLong" /label="upshifts" CDS 399560..401314 /gene="yclG" /locus_tag="BSU_03680" /old_locus_tag="BSU03680" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative uronase" /protein_id="NP_388250.1" /db_xref="EnsemblGenomes-Gn:BSU03680" /db_xref="EnsemblGenomes-Tr:CAB12176" /db_xref="InterPro:IPR006626" /db_xref="InterPro:IPR006633" /db_xref="InterPro:IPR011050" /db_xref="InterPro:IPR012334" /db_xref="InterPro:IPR024535" /db_xref="SubtiList:BG12028" /db_xref="UniProtKB/Swiss-Prot:P94409" /translation="MAEFILNAADFGVPRDGKTDSTERINQCLSTAVSKGYHTVWFPK GTYLIDATLGGDLNQRFRNAGIIVPGNLEIMMDPECIMKVIPNSSWGYSAFYVGKQEN ITISGGQIIGERDEHTYASAGIRSTHEWGFGICIEGCSNVVIDDVKISDFTGDGIIVS PRGLKTNQDYRTSEQIIIRRCEVRRSRRNNISITGCDMVTVEECLIEDAGTGNGTAPK FGIDIEGYGEGDVDYEEPINVSIRNNHFVGNVSSSVTNFNGYGILIEGNHSDNTISYG YGTQTVIKGNILRRPEDAAAAPRVGITGLGVSQGKETSDAVIAGNLITGFSTGIDVRG KSVLVTNNKISNFENTGILVYQSSDVKVDGNQIQNGLSETRRSIGLRAVLSDDIAFLN NCLIQVVDGVNVSGGNMIIKDNLLRKFSRGIWIAQGNAVIEGNTLNPDAFEAVPESYS VSVTNNAGAIIKNNTFKEFKNYPIYCSTSAKTSIIGNHLERSPLLVTIYISAGVHEIF DNTISVNRTAGNPIVIYLNGSAGSIISGNTINNLSAGTATAIQTNTSTNSKIIGNRIF KGTINKHSSDTIDGNMIV*" /label="yclG CDS" gene 399560..401314 /gene="yclG" /locus_tag="BSU_03680" /old_locus_tag="BSU03680" /label="yclG gene" promotor_-10 complement(399831..399849) /Source="Nicolas_upshift_promotors" /id="U283" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1003 /SigmaFactorBS="atcccgttcgccgataatttgtcctccggaaataGTTATAtt ctcttgcttgcctACATAAAATGCGGAATAACcccacgaactattcggtatcactttc a" /listShort="S128, dtpT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(399844) /Source="Nicolas_upshifts" /id="U283" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1003 /SigmaFactorBS="atcccgttcgccgataatttgtcctccggaaataGTTATAtt ctcttgcttgcctACATAAAATGCGGAATAACcccacgaactattcggtatcactttc a" /listShort="S128, dtpT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(399865..399870) /Source="Nicolas_upshift_promotors" /id="U283" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1003 /SigmaFactorBS="atcccgttcgccgataatttgtcctccggaaataGTTATAtt ctcttgcttgcctACATAAAATGCGGAATAACcccacgaactattcggtatcactttc a" /listShort="S128, dtpT" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 401305 /Source="Nicolas_upshifts" /id="D160" /incds=0 /nref=6 /ntot=21 /MaxReadThrough="0.325519999999999" /MaxDrop="4.9689" /score="4.29139266" /energy="-5.4" /TU="NA" /idTUdmin="U282" /TUdmin=7 /isTUend="TRUE" /label="downshifts" CDS complement(401330..401551) /gene="yczF" /locus_tag="BSU_03690" /old_locus_tag="BSU03690" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388251.1" /db_xref="EnsemblGenomes-Gn:BSU03690" /db_xref="EnsemblGenomes-Tr:CAB12177" /db_xref="GOA:O31479" /db_xref="SubtiList:BG12780" /db_xref="UniProtKB/Swiss-Prot:O31479" /translation="MKILGVTGFILICLLAISVLMDMLQGFSLTKAVYNNMSSFKMTT FAEWVVLLFFVLVLVREMYVIYKSKKKNP*" /label="yczF CDS" gene complement(401330..401551) /gene="yczF" /locus_tag="BSU_03690" /old_locus_tag="BSU03690" /label="yczF gene" promotor_-10 complement(401570..401581) /Source="Nicolas_upshift_promotors" /id="U284" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=857 /SigmaFactorBS="aaattgagattatgcattagggttagatgcGGTATAActtct ccgccaaagATAGACACTAAAagcggaggatgatgaagcatgaagatattgggcgtga c" /listShort="yczF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(401572) /Source="Nicolas_upshifts" /id="U284" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=857 /SigmaFactorBS="aaattgagattatgcattagggttagatgcGGTATAActtct ccgccaaagATAGACACTAAAagcggaggatgatgaagcatgaagatattgggcgtga c" /listShort="yczF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(401596..401602) /Source="Nicolas_upshift_promotors" /id="U284" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=857 /SigmaFactorBS="aaattgagattatgcattagggttagatgcGGTATAActtct ccgccaaagATAGACACTAAAagcggaggatgatgaagcatgaagatattgggcgtga c" /listShort="yczF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 401617..401623 /Source="Nicolas_upshift_promotors" /id="U285" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=903 /SigmaFactorBS="gagaagttataccgcatctaaccctaaTGCATAAtctcaatt ttaaaAGGAAGAATATGagaaaacgacaaggaaaggtatttgtgtatgcctttatttt c" /listShort="gerKA, gerKC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 401637..401648 /Source="Nicolas_upshift_promotors" /id="U285" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=903 /SigmaFactorBS="gagaagttataccgcatctaaccctaaTGCATAAtctcaatt ttaaaAGGAAGAATATGagaaaacgacaaggaaaggtatttgtgtatgcctttatttt c" /listShort="gerKA, gerKC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 401650 /Source="Nicolas_upshifts" /id="U285" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=903 /SigmaFactorBS="gagaagttataccgcatctaaccctaaTGCATAAtctcaatt ttaaaAGGAAGAATATGagaaaacgacaaggaaaggtatttgtgtatgcctttatttt c" /listShort="gerKA, gerKC" /GFF_Attribute="listLong" /label="upshifts" CDS 401677..403311 /gene="gerKA" /locus_tag="BSU_03700" /old_locus_tag="BSU03700" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10762253, 16707705, 16740944" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10762253, 16707705, 16740944; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination receptor subunit" /protein_id="NP_388252.1" /db_xref="EnsemblGenomes-Gn:BSU03700" /db_xref="EnsemblGenomes-Tr:CAB12178" /db_xref="GOA:P49939" /db_xref="InterPro:IPR004995" /db_xref="SubtiList:BG11392" /db_xref="UniProtKB/Swiss-Prot:P49939" /translation="MPLFSKRKNNTDSKDKQNTDERNQEQQQEKERPVLISPSLAKNI AETKKEVGSSSDVIIREIKIGEQDHVHLAVIYISGLVDNNTIHESLIDPLVQDESIQN THAIQQILEKTLPLGGVKAEKSWDKLFSELMLGNALIFADGHDEALICSTQGGEQRSI QEPSTQVSFRGPRQGFTESLQTNISMIRRYIKNPNLWVEKMKKGSVTNTDIALMYIQG ICDEKVLKEVKQRLEKIDIDSILESGYIEQLIEDETFTTFPTMYHTERPDVVAGNLLE GRFAIIVDGTPFVLIAPALFVQFFQSVEDYYSRFDIATSIRILRVLVFFISLVAPAVY VAATTFHQEMIPTQLLVVIAAQREIVPFPAVVEALTMEVAFEILREAGVRLPRVVGSA VSIVGALVIGQAAVQAGIVSPAMVIIVALTAIASFATPAFAMAISARLIRFIFIIASA VMGFYGLILGIIMMFVHLCSLRSFGVPYMSPLAPFSSQGVKDALFRVPWWADEKRPES VSKEDKVRQGKDQRPEPAASRGMVNKDLEEGDQNGT*" /label="gerKA CDS" gene 401677..403311 /gene="gerKA" /locus_tag="BSU_03700" /old_locus_tag="BSU03700" /label="gerKA gene" CDS 403301..404524 /gene="gerKC" /locus_tag="BSU_03710" /old_locus_tag="BSU03710" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10762253, 16707705, 16740944, 19363077" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10762253, 16707705, 16740944, 19363077; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination receptor subunit" /protein_id="NP_388253.1" /db_xref="EnsemblGenomes-Gn:BSU03710" /db_xref="EnsemblGenomes-Tr:CAB12179" /db_xref="GOA:P49941" /db_xref="InterPro:IPR008844" /db_xref="SubtiList:BG11394" /db_xref="UniProtKB/Swiss-Prot:P49941" /translation="MVRKCLLAVLMLLSVIVLPGCWDKRELTDLAIISAIGIDRTNDS NYVLHLQIINPGNVAGGLQGGGAGDRPPVSVYSIEGNNITEALRKASMKVSRRLYFAH TNLVVINEKLAKEEGLDFVLDNLDRDTEFRTTATFVVAHKTKAENIVKILTPIDKIPS NKVNKTLDFTEAQYGRVVKINIQDVLKTLAANTMAPVIPGYMMIGDDKKGVSMENTQA TDPKAILQADGLAVFDKAGYLKYWLEDDESVGAVWLMNKIQHTFINADWGKTKDAVSL QVTHQDTKLVPKMRNGRPYIHVKVSVEGIIDAVKYPFQLSDPKVLAAIEKALNKELEK EISHTVKKIKKNKIDFIGFGDTIYRKYPEQWEKMKDTWDKEYLPELPIDVKAETYIRR TGLRNNPIKHQFKDD*" /label="gerKC CDS" gene 403301..404524 /gene="gerKC" /locus_tag="BSU_03710" /old_locus_tag="BSU03710" /label="gerKC gene" CDS 404549..405670 /gene="gerKB" /locus_tag="BSU_03720" /old_locus_tag="BSU03720" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10762253, 15849754, 16707705, 16740944, 16850406, 19363077" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10762253, 15849754, 16707705, 16740944, 16850406, 19363077; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="spore germination receptor subunit" /protein_id="NP_388254.1" /db_xref="EnsemblGenomes-Gn:BSU03720" /db_xref="EnsemblGenomes-Tr:CAB12180" /db_xref="GOA:P49940" /db_xref="InterPro:IPR004761" /db_xref="SubtiList:BG11393" /db_xref="UniProtKB/Swiss-Prot:P49940" /translation="MEKARISIRQLFVMIIIFELGSSLLITPGSMAGRDAWIAVLLGC AIGLFLFYLYQGIYQCYPNSSPKEYMDDMLGTKLSWLFSFLYILYFAYIAARVLRDFG EMLLTFAYHDTPIIIVNALLMVVSIYAVRKGIEVLARAAELLFGAMYLLGAIGLVLII VSGTIDPHNLKPVLANGISPVLHSVFTQTMYVPFGEVVLFVMIFPNLNDRKDVKKMGM IAMAISGLIVALTVAINISVLDVDLTLRSQFPLLSTIQTIKVEEFLDRLDVFFMLALI IGGFFKVSLYLYATVVGTSTLFKEKNPSQLAYPMGLGILILSITIATNFSEHLNEGLN VVPLYIHLPFQLLFPLFLFIVAVWKKKRREKSKGEEAKK*" /label="gerKB CDS" gene 404549..405670 /gene="gerKB" /locus_tag="BSU_03720" /old_locus_tag="BSU03720" /label="gerKB gene" downshifts 405654 /Source="Nicolas_upshifts" /id="D161" /incds=0 /nref=6 /ntot=58 /MaxReadThrough="2.55658" /MaxDrop="3.73002" /score="3.39927899" /energy="-10.5" /TU="NA" /idTUdmin="U285" /TUdmin=2200 /isTUend="FALSE" /label="downshifts" CDS complement(405775..406455) /gene="yclH" /locus_tag="BSU_03730" /old_locus_tag="BSU03730" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATPase component)" /protein_id="NP_388255.1" /db_xref="EnsemblGenomes-Gn:BSU03730" /db_xref="EnsemblGenomes-Tr:CAB12181" /db_xref="GOA:P94411" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12029" /db_xref="UniProtKB/Swiss-Prot:P94411" /translation="MSLLQFQQVGYWYKNKSQPLFQDINISFQKGKFYTIVGTSGTGK TTFLSLAGGLDAPKEGNILYDGKAVSKIGLTNFRNQYVSIVFQAYNLLPYMTALQNVT TAMEITGSKEKNKESYALDMLQKVGINEKQARQKVLTLSGGQQQRVSITRAFCCDTDL IVADEPTGNLDEDTSKEIVRLFQDLAHKEDKCVIMVTHDEQIAKVSDINIRLSRGSFT VKENVAVV*" /label="yclH CDS" gene complement(405775..406455) /gene="yclH" /locus_tag="BSU_03730" /old_locus_tag="BSU03730" /label="yclH gene" CDS complement(406471..407931) /gene="yclI" /locus_tag="BSU_03740" /old_locus_tag="BSU03740" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_388256.2" /db_xref="EnsemblGenomes-Gn:BSU03740" /db_xref="EnsemblGenomes-Tr:CAB12182" /db_xref="GOA:P94412" /db_xref="InterPro:IPR003838" /db_xref="InterPro:IPR025857" /db_xref="SubtiList:BG12030" /db_xref="UniProtKB/Swiss-Prot:P94412" /translation="MNFIKRAFWNMKAKKGKTLLQLFVFTVICVFVLSGLAIQSAAQK SSELARQELGGSVTLQVDRQKQMEKQQDSGEKRSFESTPIKVSDANKLAALDHVKSYN YTTSASANAGNFDAIESSSSSDSSSSSSSSNAKNSQGGGQGGPQMVQADLSIEGVIST ALVDDFSDGDSKITDGRAITKSDVGKKVTVINETLAEENDLSVGDSITIESATDEDTT VKLKIVGIYKTTSSGDDQAQNFSFLNPYNKLYTPYTATAALKGDDYKNTIDSAVYYMD DAKNMDTFVKAAKKTSIDFDTYTLNTNDQLYQQMVGPIENVASFSKNVVYLVSVAGAV ILGLIVMMSIRERKYEMGVLMAIGEKRWKLIGQFLTEILIVAVIAIGLASVTGNLVAN QLGNQLLSQQISSSTDSTQTASGQMPGGGGGMGGKMFGHSSSNVDVIDSLNVAVSMND MLILGGIGILIAIIATLLPSISVLRLHPKTILTKQE*" /label="yclI CDS" gene complement(406471..407931) /gene="yclI" /locus_tag="BSU_03740" /old_locus_tag="BSU03740" /label="yclI gene" misc_feature 408101..408120 /Source="Nicolas_upshift_promotors" /id="U286" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.647352647352647" /psig="0.962037962037962" /xcortree=1584 /SigmaFactorBS="tctagttgatgaaataaaaactaacaattgtgaaacgcaaaa ccttctgtttaaaatGGTGCTATTATATAAAAAAGcatcaaaacaaccggaggatata a" /listShort="yclJ, yclK, S129, rapC, phrC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 408104 /Source="Nicolas_upshifts" /id="U286" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.647352647352647" /psig="0.962037962037962" /xcortree=1584 /SigmaFactorBS="tctagttgatgaaataaaaactaacaattgtgaaacgcaaaa ccttctgtttaaaatGGTGCTATTATATAAAAAAGcatcaaaacaaccggaggatata a" /listShort="yclJ, yclK, S129, rapC, phrC" /GFF_Attribute="listLong" /label="upshifts" CDS 408144..408827 /gene="yclJ" /locus_tag="BSU_03750" /old_locus_tag="BSU03750" /function="16.10: Respire" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 15375128, 20512483" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15375128, 20512483; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YclK] (possibly involved in arabinogalactan metabolism)" /protein_id="NP_388257.1" /db_xref="EnsemblGenomes-Gn:BSU03750" /db_xref="EnsemblGenomes-Tr:CAB12183" /db_xref="GOA:P94413" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12031" /db_xref="UniProtKB/Swiss-Prot:P94413" /translation="MKILMIEDNVSVCTMTEMFFFKEGFEAEFVHDGLEGYQRFTEEN WDLIILDIMLPSMDGVTICRKIRETSTVPIIMLTAKDTESDQVIGFEMGADDYVTKPF SPLTLVARIKAVIRRYKATGKAVIDEDMIETECFTINKKTREVLLNGEPVENLTPKEF DLLYYLVQNPRQVFSREQLLEQVWGYQFYGDERTVDVHIKRLRKKLASEDKPFLYTVW GVGYKFDED*" /label="yclJ CDS" gene 408144..408827 /gene="yclJ" /locus_tag="BSU_03750" /old_locus_tag="BSU03750" /label="yclJ gene" CDS 408814..410235 /gene="yclK" /locus_tag="BSU_03760" /old_locus_tag="BSU03760" /function="16.3: Control" /function="16.10: Respire" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295, 15375128, 20512483" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15375128, 20512483; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YclJ]" /protein_id="NP_388258.1" /db_xref="EnsemblGenomes-Gn:BSU03760" /db_xref="EnsemblGenomes-Tr:CAB12184" /db_xref="GOA:P94414" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12032" /db_xref="UniProtKB/Swiss-Prot:P94414" /translation="MMKIKYLYQLLLSHISILILAFVIIISLFSHFVKEFAYQNKVEE LTSYAVQIANEFQSGQVDMRRLYPYQDILSTRKTQFIIFNEEQQPYFLPEGFHHPPRE QLKKSEWNKLKKGQTVTIRADGRFDDEVSLVAQPIFVQNEFKGAVLLISPISGVEQMV NQVNLYMFYAVISTLVITILVSWLLSKFHVKRIQKLREATDKVASGDYDIHLENSYGD EIGVLASDFNIMAKKLKQSRDEIERLEKRRRQFIADVSHELKTPLTTINGLVEGLNSH TIPEDKKDKCFSLISEETKRMLRLVKENLDYEKIRSQQITLNKLDVPLIEVFEIVKEH LQQQAEEKQNKLMIQVEDHVIVHADYDRFIQILVNITKNSIQFTQNGDIWLRGMEGYK ETIIEIEDTGIGIPKEDIEHIWERFYKADISRTNTAYGEYGLGLSIVRQLVEMHQGTV EIKSEEGKGTKFIIRLPLTAKQQ*" /label="yclK CDS" gene 408814..410235 /gene="yclK" /locus_tag="BSU_03760" /old_locus_tag="BSU03760" /label="yclK gene" downshifts 410211 /Source="Nicolas_upshifts" /id="D162" /incds=0 /nref=20 /ntot=169 /MaxReadThrough="3.43905" /MaxDrop="4.91565" /score="13.4599201" /energy="-15" /TU="U286" /idTUdmin="U286" /TUdmin="-1427" /isTUend="FALSE" /label="downshifts" S_feature 410256..410360 /Source="Nicolas_S_feature" /locus_tag="new_428689_428793" /HighExp="Lbstat, nit, ferm, BI, M0t45, M40t45, M0t90, S0, S2, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.962" /TUlongSig="NA" /TUlongPSig="NA" /label="S129" misc_feature 410350..410369 /Source="Nicolas_upshift_promotors" /id="U287" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.96903096903097" /psig="0.986013986013986" /xcortree=678 /SigmaFactorBS="tcccgaaaacaaagattgcgtgtttttcgggttgggacggcc tataaaCATGATAAAATATGACATAAacagtttttgatgggagagggtgaaggaatga a" /listShort="rapC, phrC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 410362 /Source="Nicolas_upshifts" /id="U287" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.96903096903097" /psig="0.986013986013986" /xcortree=678 /SigmaFactorBS="tcccgaaaacaaagattgcgtgtttttcgggttgggacggcc tataaaCATGATAAAATATGACATAAacagtttttgatgggagagggtgaaggaatga a" /listShort="rapC, phrC" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(410394) /Source="Nicolas_upshifts" /id="D163" /incds=0 /nref=2 /ntot=81 /MaxReadThrough="1.74985" /MaxDrop="4.10695" /score="1.47729412" /energy="-10.3" /TU="NA" /idTUdmin="U290" /TUdmin=1320 /isTUend="FALSE" /label="downshifts" CDS 410398..411546 /gene="rapC" /locus_tag="BSU_03770" /old_locus_tag="BSU03770" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10464187, 12456319, 12897006, 12950917, 15968044, 19202088" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10464187, 12456319, 12897006, 12950917, 15968044, 19202088; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="response regulator aspartate phosphatase" /protein_id="NP_388259.1" /db_xref="EnsemblGenomes-Gn:BSU03770" /db_xref="EnsemblGenomes-Tr:CAB12185" /db_xref="GOA:P94415" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="SubtiList:BG11966" /db_xref="UniProtKB/Swiss-Prot:P94415" /translation="MKSGVIPSSAVGQKINEWYRYIRTFSVPDAEVLKAEIQQELKHM QHDSNLLLYYSLMEFRHQLMLDYLEPLEKLNIEDQPSLSELSRNIDSNQADLKGLLDY YVNFFRGMYEFDKREFISAITYYKQAEKKLSFVADHIERAEFYFKIAEAYYYMKQTYF SLINIKNAYEIYVEQETYNVRIIQCHFVFGVNLMDERNFEQAARHFKLALNMAQAEQK AQLVGRAYYNLGLCYYNQDLLDPAIDYFEKAVSTFESSRIVNSLPQAYFLITLIYYKQ GKHDKASEYHKRGYEYAKETDDADYAVKFEFLQSLYLDQPNEEGIERCFQYLKNKNMY ADIEDLALEVAKYYYEQKWFKLSASYFLQVEEARKQIQRSEGLYEIEI*" /label="rapC CDS" gene 410398..411546 /gene="rapC" /locus_tag="BSU_03770" /old_locus_tag="BSU03770" /label="rapC gene" promotor_-35 411246..411251 /Source="Nicolas_upshift_promotors" /id="U288" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.776223776223776" /psig="0.776223776223776" /xcortree=1063 /SigmaFactorBS="caccctgatttattataaacagggaaaacatgataaagcttc GGAATAtcacaagcggggctatGAATATGCTAAAGAAACAGacgatgcagactatgcc g" /listShort="phrC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 411264 /Source="Nicolas_upshifts" /id="U288" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.776223776223776" /psig="0.776223776223776" /xcortree=1063 /SigmaFactorBS="caccctgatttattataaacagggaaaacatgataaagcttc GGAATAtcacaagcggggctatGAATATGCTAAAGAAACAGacgatgcagactatgcc g" /listShort="phrC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 411268..411286 /Source="Nicolas_upshift_promotors" /id="U288" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.776223776223776" /psig="0.776223776223776" /xcortree=1063 /SigmaFactorBS="caccctgatttattataaacagggaaaacatgataaagcttc GGAATAtcacaagcggggctatGAATATGCTAAAGAAACAGacgatgcagactatgcc g" /listShort="phrC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 411408..411416 /Source="Nicolas_upshift_promotors" /id="U289" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.753246753246753" /psig="0.753246753246753" /xcortree=788 /SigmaFactorBS="taaaaaataaaaatatgtacgctgatatAGAGGATTTagccc tagaagTAGCAAAATATTACTATGAacagaaatggtttaaactgtctgcttcctactt t" /listShort="phrC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 411428..411446 /Source="Nicolas_upshift_promotors" /id="U289" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.753246753246753" /psig="0.753246753246753" /xcortree=788 /SigmaFactorBS="taaaaaataaaaatatgtacgctgatatAGAGGATTTagccc tagaagTAGCAAAATATTACTATGAacagaaatggtttaaactgtctgcttcctactt t" /listShort="phrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 411440 /Source="Nicolas_upshifts" /id="U289" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.753246753246753" /psig="0.753246753246753" /xcortree=788 /SigmaFactorBS="taaaaaataaaaatatgtacgctgatatAGAGGATTTagccc tagaagTAGCAAAATATTACTATGAacagaaatggtttaaactgtctgcttcctactt t" /listShort="phrC" /GFF_Attribute="listLong" /label="upshifts" CDS 411530..411652 /gene="phrC" /locus_tag="BSU_03780" /old_locus_tag="BSU03780" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10464187, 12456319, 12897006, 12950917, 16816200, 19202088" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10464187, 12456319, 12897006, 12950917, 16816200, 19202088; Product type r : regulator" /codon_start=1 /transl_table=11 /product="secreted regulator of the activity of phosphatase RapC and competence and sporulation stimulating factor (CSF)" /protein_id="NP_388260.1" /db_xref="EnsemblGenomes-Gn:BSU03780" /db_xref="EnsemblGenomes-Tr:CAB12186" /db_xref="GOA:P94416" /db_xref="InterPro:IPR020243" /db_xref="InterPro:IPR025899" /db_xref="SubtiList:BG11959" /db_xref="UniProtKB/Swiss-Prot:P94416" /translation="MKLKSKLFVICLAAAAIFTAAGVSANAEALDFHVTERGMT*" /label="phrC CDS" gene 411530..411652 /gene="phrC" /locus_tag="BSU_03780" /old_locus_tag="BSU03780" /label="phrC gene" downshifts 411639 /Source="Nicolas_upshifts" /id="D164" /incds=0 /nref=260 /ntot=275 /MaxReadThrough="3.24518" /MaxDrop="7.70367" /score="26.3182765" /energy="-14" /TU="NA" /idTUdmin="U286" /TUdmin=1 /isTUend="TRUE" /label="downshifts" downshifts complement(411707) /Source="Nicolas_upshifts" /id="D165" /incds=0 /nref=3 /ntot=64 /MaxReadThrough="0.60499" /MaxDrop="7.4475" /score="-1.25354129" /energy="-15.8" /TU="NA" /idTUdmin="U290" /TUdmin=7 /isTUend="TRUE" /label="downshifts" CDS complement(411752..411841) /gene="yczM" /locus_tag="BSU_03788" /old_locus_tag="BSU03788" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20156992, 21670523; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative type I toxin" /protein_id="YP_003097676.1" /db_xref="EnsemblGenomes-Gn:BSU03788" /db_xref="EnsemblGenomes-Tr:CAX52547" /db_xref="GOA:C0H3V0" /db_xref="InterPro:IPR010070" /db_xref="UniProtKB/Swiss-Prot:C0H3V0" /translation="MSGYGTSFALIVVLFILLIIVGTAFVGGY*" /label="yczM CDS" gene complement(411752..411841) /gene="yczM" /locus_tag="BSU_03788" /old_locus_tag="BSU03788" /label="yczM gene" downshifts complement(411912) /Source="Nicolas_upshifts" /id="D166" /incds=0 /nref=25 /ntot=113 /MaxReadThrough="7.05273" /MaxDrop="3.3619" /score="32.1465401" /energy="-16.5" /TU="U290" /idTUdmin="U290" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" CDS complement(411923..412036) /gene="yczN" /locus_tag="BSU_03789" /old_locus_tag="BSU03789" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 21670523; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative spore and germination protein" /protein_id="YP_003097677.1" /db_xref="EnsemblGenomes-Gn:BSU03789" /db_xref="EnsemblGenomes-Tr:CAX52548" /db_xref="GOA:C0H3V1" /db_xref="InterPro:IPR010070" /db_xref="UniProtKB/Swiss-Prot:C0H3V1" /translation="MSGYSNGGGYGGISSFALIVVLFILLIIVGTAFVGGF*" /label="yczN CDS" gene complement(411923..412036) /gene="yczN" /locus_tag="BSU_03789" /old_locus_tag="BSU03789" /label="yczN gene" promotor_-10 complement(412057..412076) /Source="Nicolas_upshift_promotors" /id="U290" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1406 /SigmaFactorBS="attcttcattttttctcttgtccactattaTCCCTGCCAAat ggatcggttcAGCATATCTTATAGTATCCTtcatagggaggtgaaaccttatgtcagg a" /listShort="yczN, yczM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(412068) /Source="Nicolas_upshifts" /id="U290" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1406 /SigmaFactorBS="attcttcattttttctcttgtccactattaTCCCTGCCAAat ggatcggttcAGCATATCTTATAGTATCCTtcatagggaggtgaaaccttatgtcagg a" /listShort="yczN, yczM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(412089..412098) /Source="Nicolas_upshift_promotors" /id="U290" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1406 /SigmaFactorBS="attcttcattttttctcttgtccactattaTCCCTGCCAAat ggatcggttcAGCATATCTTATAGTATCCTtcatagggaggtgaaaccttatgtcagg a" /listShort="yczN, yczM" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(412190..413554) /gene="thrD" /locus_tag="BSU_03790" /old_locus_tag="BSU03790" /EC_number="2.7.2.4" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2152900, 11471740, 27260660" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2152900, 11471740, 27260660; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aspartate kinase III" /protein_id="NP_388261.1" /db_xref="EnsemblGenomes-Gn:BSU03790" /db_xref="EnsemblGenomes-Tr:CAB12187" /db_xref="GOA:P94417" /db_xref="InterPro:IPR001048" /db_xref="InterPro:IPR001341" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR005260" /db_xref="InterPro:IPR018042" /db_xref="InterPro:IPR027795" /db_xref="InterPro:IPR035804" /db_xref="InterPro:IPR036393" /db_xref="SubtiList:BG12033" /db_xref="UniProtKB/Swiss-Prot:P94417" /translation="MKVVKFGGSSLASGAQLDKVFHIVTSDPARKAVVVSAPGKHYAE DTKVTDLLIACAEQYLATGSAPELAEAVVERYALIANELQLGQSIIEKIRDDLFTLLE GDKSNPEQYLDAVKASGEDNNAKLIAAYFRYKGVKAEYVNPKDAGLFVTNEPGNAQVL PESYQNLYRLRERDGLIIFPGFFGFSKDGDVITFSRSGSDITGSILANGLQADLYENF TDVDAVYSVNPSFVENPKEISELTYREMRELSYAGFSVFHDEALIPAFRAGIPVQIKN TNNPSAEGTRVVSKRDNTNGPVVGIASDTGFCSIYISKYLMNREIGFGRRALQILEEH GLTYEHVPSGIDDMTIILRQGQMDAATERSVIKRIEEDLHADEVIVEHHLALIMVVGE AMRHNVGTTARAAKALSEAQVNIEMINQGSSEVSMMFGVKEAEERKAVQALYQEFFAG VLIS*" /label="thrD CDS" gene complement(412190..413554) /gene="thrD" /locus_tag="BSU_03790" /old_locus_tag="BSU03790" /label="thrD gene" downshifts complement(412198) /Source="Nicolas_upshifts" /id="D167" /incds=0 /nref=23 /ntot=129 /MaxReadThrough="2.21842" /MaxDrop="4.81019" /score="44.9085917" /energy="-15" /TU="NA" /idTUdmin="U291" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(412242) /Source="Nicolas_upshifts" /id="D168" /incds=0 /nref=1 /ntot=17 /MaxReadThrough="5.53807" /MaxDrop="2.54279" /score="44.9085917" /energy="-15" /TU="U291" /idTUdmin="U291" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(413590..413609) /Source="Nicolas_upshift_promotors" /id="U291" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.946053946053946" /psig="0.999000999001" /xcortree=3042 /SigmaFactorBS="aaaaatacaaatgttctcctgagaaagaaattcccCCTTGAT TtacagtactgaaagAGAGATAATAAATACTAAATttgtgtgaaaattttaaacatta g" /listShort="yclM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(413606) /Source="Nicolas_upshifts" /id="U291" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.946053946053946" /psig="0.999000999001" /xcortree=3042 /SigmaFactorBS="aaaaatacaaatgttctcctgagaaagaaattcccCCTTGAT TtacagtactgaaagAGAGATAATAAATACTAAATttgtgtgaaaattttaaacatta g" /listShort="yclM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(413624..413631) /Source="Nicolas_upshift_promotors" /id="U291" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.946053946053946" /psig="0.999000999001" /xcortree=3042 /SigmaFactorBS="aaaaatacaaatgttctcctgagaaagaaattcccCCTTGAT TtacagtactgaaagAGAGATAATAAATACTAAATttgtgtgaaaattttaaacatta g" /listShort="yclM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 413745..413749 /Source="Nicolas_upshift_promotors" /id="U292" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.843156843156843" /psig="0.997002997002997" /xcortree=2746 /SigmaFactorBS="aaatatggtaaacagcctaacgttttggGATGGaaaatggtt agaatgATTAGTAAAATTGATAAATGactaggttaatatttttaaagaatattgacta a" /listShort="S130, yclN, yclO, yclP, yclQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 413765..413784 /Source="Nicolas_upshift_promotors" /id="U292" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.843156843156843" /psig="0.997002997002997" /xcortree=2746 /SigmaFactorBS="aaatatggtaaacagcctaacgttttggGATGGaaaatggtt agaatgATTAGTAAAATTGATAAATGactaggttaatatttttaaagaatattgacta a" /listShort="S130, yclN, yclO, yclP, yclQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 413777 /Source="Nicolas_upshifts" /id="U292" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.843156843156843" /psig="0.997002997002997" /xcortree=2746 /SigmaFactorBS="aaatatggtaaacagcctaacgttttggGATGGaaaatggtt agaatgATTAGTAAAATTGATAAATGactaggttaatatttttaaagaatattgacta a" /listShort="S130, yclN, yclO, yclP, yclQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 413808..413815 /Source="Nicolas_upshift_promotors" /id="U293" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.926073926073926" /psig=1 /xcortree=2099 /SigmaFactorBS="ataaatgactaggttaatatttttaaagaaTATTGACTaacc ctataaaaaTGGTAATATGTAAATGATAAtgataatcaattactatatggccatattg t" /listShort="S130, yclN, yclO, yclP, yclQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 413829..413848 /Source="Nicolas_upshift_promotors" /id="U293" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.926073926073926" /psig=1 /xcortree=2099 /SigmaFactorBS="ataaatgactaggttaatatttttaaagaaTATTGACTaacc ctataaaaaTGGTAATATGTAAATGATAAtgataatcaattactatatggccatattg t" /listShort="S130, yclN, yclO, yclP, yclQ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 413838..413938 /Source="Nicolas_S_feature" /locus_tag="new_432271_432371" /HighExp="LBGexp, Lbexp, G150, dia0, G135, H2O2, Paraq, dia15, G180, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S130" upshifts 413838 /Source="Nicolas_upshifts" /id="U293" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.926073926073926" /psig=1 /xcortree=2099 /SigmaFactorBS="ataaatgactaggttaatatttttaaagaaTATTGACTaacc ctataaaaaTGGTAATATGTAAATGATAAtgataatcaattactatatggccatattg t" /listShort="S130, yclN, yclO, yclP, yclQ" /GFF_Attribute="listLong" /label="upshifts" CDS 413939..414889 /gene="pbtN" /locus_tag="BSU_03800" /old_locus_tag="BSU03800" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 15849754, 16850406, 19955416" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15849754, 16850406, 19955416; Product type t: transporter" /codon_start=1 /transl_table=11 /product="petrobactin iron-siderophore ABC transporter (permease)" /protein_id="NP_388262.1" /db_xref="EnsemblGenomes-Gn:BSU03800" /db_xref="EnsemblGenomes-Tr:CAB12188" /db_xref="GOA:P94418" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG12034" /db_xref="UniProtKB/Swiss-Prot:P94418" /translation="MKLRYLFILLIILAVTSVFIGVEDLSPLDLFDLSKQEASTLFAS RLPRLISIVIAGLSMSICGLIMQQISRNKFVSPTTAGTMDWARLGILISLLLFTSASP LIKMLVAFVFALAGNFLFMKILERIKFNDTIFIPLVGLMLGNIVSSIATFIAYKYDLI QNVSSWLQGDFSLVVKGRYELLYLSIPLVIIAYVYADKFTLAGMGESFSVNLGLKYKR VVNIGLIIVSLITSLVILTVGMLPFLGLIIPNIVSIYRGDNLKSSLPHTVLLGAVFVL FCDILGRIIIFPYEISIGLMVGIIGSGIFLFMLLRRKAYA*" /label="pbtN CDS" gene 413939..414889 /gene="pbtN" /locus_tag="BSU_03800" /old_locus_tag="BSU03800" /label="pbtN gene" CDS 414882..415829 /gene="pbtO" /locus_tag="BSU_03810" /old_locus_tag="BSU03810" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 15849754, 16850406, 19955416" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15849754, 16850406, 19955416; Product type t: transporter" /codon_start=1 /transl_table=11 /product="petrobactin iron-siderophore ABC transporter (permease)" /protein_id="NP_388263.1" /db_xref="EnsemblGenomes-Gn:BSU03810" /db_xref="EnsemblGenomes-Tr:CAB12189" /db_xref="GOA:P94419" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG12035" /db_xref="UniProtKB/Swiss-Prot:P94419" /translation="MRNQMKIALLVGLAIVCIGLFLFYDLGNWDYTLPRRIKKVAAIV LTGGAIAFSTMIFQTITNNRILTPSILGLDSLYMLIQTGIIFLFGSANMVIMNKNINF IISVLLMILFSLVLYQIMFKGEGRNIFFLLLIGIVFGTLFSSLSSFMQMLIDPNEFQV VQDKMFASFNNINTDLLWLAFIIFLLTGVYVWRFTKFFDVLSLGREHAVNLGIDYDKV VKQMLIVVAILVSVSTALVGPIMFLGLLVVNLAREFLKTYKHSYLIAGSVFISIIALV GGQFVVEKVFTFSTTLSVIINFAGGIYFIYLLLKENKSW*" /label="pbtO CDS" gene 414882..415829 /gene="pbtO" /locus_tag="BSU_03810" /old_locus_tag="BSU03810" /label="pbtO gene" CDS 415823..416581 /gene="pbtP" /locus_tag="BSU_03820" /old_locus_tag="BSU03820" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 19955416" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 19955416; Product type t: transporter" /codon_start=1 /transl_table=11 /product="petrobactin iron-siderophore ABC transporter (ATP-binding protein)" /protein_id="NP_388264.1" /db_xref="EnsemblGenomes-Gn:BSU03820" /db_xref="EnsemblGenomes-Tr:CAB12190" /db_xref="GOA:P94420" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12036" /db_xref="UniProtKB/Swiss-Prot:P94420" /translation="MVEVRNVSKQYGGKVVLEETSVTIQKGKITSFIGPNGAGKSTLL SIMSRLIKKDSGEIYIDGQEIGACDSKELAKKMSILKQANQINIRLTIKDLVSFGRFP YSQGRLTEEDWVHINQALSYMKLEDIQDKYLDQLSGGQCQRAFIAMVIAQDTDYIFLD EPLNNLDMKHSVEIMKLLKRLVEELGKTIVIVIHDINFASVYSDYIVALKNGRIVKEG PPEEMIETSVLEEIYDMTIPIQTIDNQRIGVYFS*" /label="pbtP CDS" gene 415823..416581 /gene="pbtP" /locus_tag="BSU_03820" /old_locus_tag="BSU03820" /label="pbtP gene" CDS 416603..417556 /gene="pbtQ" /locus_tag="BSU_03830" /old_locus_tag="BSU03830" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 19955416, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 19955416, 25355936; Product type t: transporter" /codon_start=1 /transl_table=11 /product="petrobactin iron-siderophore ABC transporter (binding lipoprotein)" /protein_id="NP_388265.1" /db_xref="EnsemblGenomes-Gn:BSU03830" /db_xref="EnsemblGenomes-Tr:CAB12191" /db_xref="GOA:P94421" /db_xref="InterPro:IPR002491" /db_xref="InterPro:IPR033870" /db_xref="PDB:3GFV" /db_xref="SubtiList:BG12037" /db_xref="UniProtKB/Swiss-Prot:P94421" /translation="MKKFALLFIALVTAVVISACGNQSTSSKGSDTKKEQITVKHQLD KNGTKVPKNPKKVVVFDFGSLDTLDKLGLDDIVAGLPKQVLPKYLSKFKDDKYADVGS LKEPDFDKVAELDPDLIIISARQSESYKEFSKIAPTIYLGVDTAKYMESFKSDAETIG KIFDKEDKVKDELANIDHSIADVKKTAEKLNKNGLVIMANDGKISAFGPKSRYGLIHD VFGVAPADQNIKASTHGQSVSYEYISKTNPDYLFVIDRGTAIGETSSTKQVVENDYVK NVNAVKNGHVIYLDSATWYLSGGGLESMTQMIKEVKDGLEK*" /label="pbtQ CDS" gene 416603..417556 /gene="pbtQ" /locus_tag="BSU_03830" /old_locus_tag="BSU03830" /label="pbtQ gene" downshifts 417539 /Source="Nicolas_upshifts" /id="D169" /incds=0 /nref=161 /ntot=280 /MaxReadThrough="3.87669" /MaxDrop="7.4722" /score="31.9942335" /energy="-13.8" /TU="U293" /idTUdmin="U292" /TUdmin=5 /isTUend="TRUE" /label="downshifts" CDS complement(417603..419021) /gene="ycnB" /locus_tag="BSU_03840" /old_locus_tag="BSU03840" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 15855514, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388266.1" /db_xref="EnsemblGenomes-Gn:BSU03840" /db_xref="EnsemblGenomes-Tr:CAB12192" /db_xref="GOA:P94422" /db_xref="InterPro:IPR004638" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12038" /db_xref="UniProtKB/Swiss-Prot:P94422" /translation="MNTSIEQKPFNRSVIVGILLAGAFVAILNQTLLITALPHIMRDF NVDANQAQWLTTSFMLTNGILIPITAFLIEKFTSRALLITAMSIFTAGTVVGAFAPNF PVLLTARIIQAAGAGIMMPLMQTVFLTIFPIEKRGQAMGMVGLVISFAPAIGPTLSGW AVEAFSWRSLFYIILPFAVIDLILASILMKNVTTLRKTQIDILSVILSTFGFGGLLYG FSSVGSYGWSSSTVLISLLVGVIALLLFITRQMKLKKPMLEFRVFTFGVFSLTTLLGT LVFALLIGTETILPLYTQNVRDVTAFDTGLMLLPGAVVMGFMSPIIGRIFDRVGGRGL AIAGFCIIFLTSLPFMQLTDHTSLAWIVVLYTVRLLGTAMIMMPVTTAGINALPRHLI PHGTAMNNTIRQVGGSIGTALLVSVMSNQAAHAGTTNVKHAALHGMNAAFIVAAVIAL VGFLLSFTLKKPQRPAEQQPAR*" /label="ycnB CDS" gene complement(417603..419021) /gene="ycnB" /locus_tag="BSU_03840" /old_locus_tag="BSU03840" /label="ycnB gene" downshifts complement(417624) /Source="Nicolas_upshifts" /id="D170" /incds=0 /nref=8 /ntot=150 /MaxReadThrough="2.00954" /MaxDrop="5.13029" /score="17.5501827" /energy="-13.8" /TU="NA" /idTUdmin="U294" /TUdmin="-14" /isTUend="TRUE" /label="downshifts" CDS complement(419041..419919) /gene="ycnC" /locus_tag="BSU_03850" /old_locus_tag="BSU03850" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (TetR/AcrR family)" /protein_id="NP_388267.2" /db_xref="EnsemblGenomes-Gn:BSU03850" /db_xref="EnsemblGenomes-Tr:CAB12193" /db_xref="GOA:P94423" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="SubtiList:BG12039" /db_xref="UniProtKB/Swiss-Prot:P94423" /translation="MLDKKTDILLAARKLFSEKDFTSVSMQAIAEECKMSKASIYKLF QSKEDLLLELLSFNQKQMVAAASRLQENTALTPEERLTQKVKMELEGFRRNQQFFNML TYGNPKLHNDRVKQHIHQTRSTIICWHRDSLIQAYGETILPFVWDLVIILHGMMREFL MLIKIEEKPLELDPIAEFIISTLNQIIKNRETRQSLLPPEAIELYIHSASSYKPKDKS VLLSESLKELHKGISSLSAADYDVDELTSAAAMLEEEAKKEEPRAFLLKSLIGYLEQT GVLTQPVSMLKTLLIT*" /label="ycnC CDS" gene complement(419041..419919) /gene="ycnC" /locus_tag="BSU_03850" /old_locus_tag="BSU03850" /label="ycnC gene" S_feature complement(419920..419986) /Source="Nicolas_S_feature" /locus_tag="new_438353_438419_c" /HighExp="dia15, H2O2, Diami, Paraq, Oxctl, Cold, G180, Salt, BMM, GM 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S131" promotor_-10 complement(419985..420004) /Source="Nicolas_upshift_promotors" /id="U294" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.373626373626374" /psig="0.999000999001" /xcortree=2489 /SigmaFactorBS="gcaggcctttcatttacccggttaaaatcCATTGACttctat tttgtttaTCTGGTAAAATTTTTTCATTgttactcattggttttctgtgaaccaatgg g" /listShort="S131, ycnC, ycnB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(419994) /Source="Nicolas_upshifts" /id="U294" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.373626373626374" /psig="0.999000999001" /xcortree=2489 /SigmaFactorBS="gcaggcctttcatttacccggttaaaatcCATTGACttctat tttgtttaTCTGGTAAAATTTTTTCATTgttactcattggttttctgtgaaccaatgg g" /listShort="S131, ycnC, ycnB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(420019..420025) /Source="Nicolas_upshift_promotors" /id="U294" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.373626373626374" /psig="0.999000999001" /xcortree=2489 /SigmaFactorBS="gcaggcctttcatttacccggttaaaatcCATTGACttctat tttgtttaTCTGGTAAAATTTTTTCATTgttactcattggttttctgtgaaccaatgg g" /listShort="S131, ycnC, ycnB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(420083..420832) /gene="nfrAB" /locus_tag="BSU_03860" /old_locus_tag="BSU03860" /EC_number="1.5.1.39" /EC_number="1.6.99.-" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16229462, 9836433, 20862523" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16229462, 9836433, 20862523; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADPH-FMN oxidoreductase (nitroreductase)" /protein_id="NP_388268.1" /db_xref="EnsemblGenomes-Gn:BSU03860" /db_xref="EnsemblGenomes-Tr:CAB12194" /db_xref="GOA:P94424" /db_xref="InterPro:IPR000415" /db_xref="InterPro:IPR016446" /db_xref="InterPro:IPR029479" /db_xref="PDB:1ZCH" /db_xref="SubtiList:BG12040" /db_xref="UniProtKB/Swiss-Prot:P94424" /translation="MNEVIKSLTDHRSIRSYTDEPVAQEQLDQIIEAVQSAPSSINGQ QVTVITVQDKERKKKISELAGGQPWIDQAPVFLLFCADFNRAKIALEDLHDFKMEITN GLESVLVGAVDAGIALGTATAAAESLGLGTVPIGAVRGNPQELIELLELPKYVFPLSG LVIGHPADRSAKKPRLPQEAVNHQETYLNQDELTSHIQAYDEQMSEYMNKRTNGKETR NWSQSIASYYERLYYPHIREMLEKQGFKVEK*" /label="nfrAB CDS" gene complement(420083..420832) /gene="nfrAB" /locus_tag="BSU_03860" /old_locus_tag="BSU03860" /label="nfrAB gene" downshifts complement(420096) /Source="Nicolas_upshifts" /id="D171" /incds=0 /nref=136 /ntot=243 /MaxReadThrough="2.08639" /MaxDrop="5.10745" /score="11.1864402" /energy="-18.6" /TU="NA" /idTUdmin="U296" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(420849..421136) /gene="ycnE" /locus_tag="BSU_03870" /old_locus_tag="BSU03870" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17274596, 21454635; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative AI-2 degrading enzyme" /protein_id="NP_388269.1" /db_xref="EnsemblGenomes-Gn:BSU03870" /db_xref="EnsemblGenomes-Tr:CAB12195" /db_xref="GOA:P94425" /db_xref="InterPro:IPR007138" /db_xref="InterPro:IPR011008" /db_xref="SubtiList:BG12041" /db_xref="UniProtKB/Swiss-Prot:P94425" /translation="MIVLQAYIKVKPEKREEFLSEAQSLVQHSRAEEGNAQYDLFEKV GEENTFVMLEKWKDEAAMKFHNETAHFQGFVAKGKELLSAPLDVVRTELSE*" /label="ycnE CDS" gene complement(420849..421136) /gene="ycnE" /locus_tag="BSU_03870" /old_locus_tag="BSU03870" /label="ycnE gene" promotor_-35 421102..421109 /Source="Nicolas_upshift_promotors" /id="U295" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.966033966033966" /psig="0.993006993006993" /xcortree=1982 /SigmaFactorBS="aaaattcctcgcgtttttctGGTTTTACtttgatgtaagctT GTAATACGATCATGTAAATctcctccgtcgttatgcgaatttattgttcgaatttcat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 421123..421142 /Source="Nicolas_upshift_promotors" /id="U295" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.966033966033966" /psig="0.993006993006993" /xcortree=1982 /SigmaFactorBS="aaaattcctcgcgtttttctGGTTTTACtttgatgtaagctT GTAATACGATCATGTAAATctcctccgtcgttatgcgaatttattgttcgaatttcat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 421142 /Source="Nicolas_upshifts" /id="U295" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.966033966033966" /psig="0.993006993006993" /xcortree=1982 /SigmaFactorBS="aaaattcctcgcgtttttctGGTTTTACtttgatgtaagctT GTAATACGATCATGTAAATctcctccgtcgttatgcgaatttattgttcgaatttcat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(421180..421199) /Source="Nicolas_upshift_promotors" /id="U296" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.573426573426573" /psig=1 /xcortree=1945 /SigmaFactorBS="acaattagaatgacaattttactatataagggttttTCCTTT ACctcatttagaataCATGTTACATTTAGTTCGATgaaattcgaacaataaattcgca t" /listShort="ycnE, ycnD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(421196) /Source="Nicolas_upshifts" /id="U296" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.573426573426573" /psig=1 /xcortree=1945 /SigmaFactorBS="acaattagaatgacaattttactatataagggttttTCCTTT ACctcatttagaataCATGTTACATTTAGTTCGATgaaattcgaacaataaattcgca t" /listShort="ycnE, ycnD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(421213..421220) /Source="Nicolas_upshift_promotors" /id="U296" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.573426573426573" /psig=1 /xcortree=1945 /SigmaFactorBS="acaattagaatgacaattttactatataagggttttTCCTTT ACctcatttagaataCATGTTACATTTAGTTCGATgaaattcgaacaataaattcgca t" /listShort="ycnE, ycnD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 421241..421248 /Source="Nicolas_upshift_promotors" /id="U297" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.614385614385614" /psig="0.955044955044955" /xcortree=576 /SigmaFactorBS="taacatgtattctaaatgaggtaaaggaaaaacccttatata gtaaaaTTGTCATTctaattgttgTATGATACATTTGTGTCATGaacattccaaacca t" /listShort="yczG" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 421253 /Source="Nicolas_upshifts" /id="U297" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.614385614385614" /psig="0.955044955044955" /xcortree=576 /SigmaFactorBS="taacatgtattctaaatgaggtaaaggaaaaacccttatata gtaaaaTTGTCATTctaattgttgTATGATACATTTGTGTCATGaacattccaaacca t" /listShort="yczG" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 421259..421278 /Source="Nicolas_upshift_promotors" /id="U297" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.614385614385614" /psig="0.955044955044955" /xcortree=576 /SigmaFactorBS="taacatgtattctaaatgaggtaaaggaaaaacccttatata gtaaaaTTGTCATTctaattgttgTATGATACATTTGTGTCATGaacattccaaacca t" /listShort="yczG" /GFF_Attribute="listLong" /label="promotor_-10" CDS 421276..421590 /gene="yczG" /locus_tag="BSU_03880" /old_locus_tag="BSU03880" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (ArsR family)" /protein_id="NP_388270.1" /db_xref="EnsemblGenomes-Gn:BSU03880" /db_xref="EnsemblGenomes-Tr:CAB12196" /db_xref="GOA:O31480" /db_xref="InterPro:IPR001845" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12781" /db_xref="UniProtKB/Swiss-Prot:O31480" /translation="MNIPNHPETETLQLTKVLHALSDPLRLELVKQLAEAKEKTCSTC ADVQVAKSTLSHHFKVLRESGIAQVRIEGKRRYYSLRAEDLEKAFPGLLEAVLNVDQD RW*" /label="yczG CDS" gene 421276..421590 /gene="yczG" /locus_tag="BSU_03880" /old_locus_tag="BSU03880" /label="yczG gene" downshifts 421582 /Source="Nicolas_upshifts" /id="D172" /incds=0 /nref=173 /ntot=262 /MaxReadThrough="0.52252" /MaxDrop="5.32898" /score="20.7855667" /energy="-7.4" /TU="NA" /idTUdmin="U297" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(421592..423031) /gene="gabR" /locus_tag="BSU_03890" /old_locus_tag="BSU03890" /experiment="publication(s) with functional evidences, PMID:15223311, 24127574, 25388514, 27640111, 28348215, 28412355" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15223311, 24127574, 25388514, 27640111, 28348215, 28412355; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (GntR/MocR family) with PLP binding site (GabR-GABA-PLP aldimine)" /protein_id="NP_388271.1" /db_xref="EnsemblGenomes-Gn:BSU03890" /db_xref="EnsemblGenomes-Tr:CAB12197" /db_xref="GOA:P94426" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:4MGR" /db_xref="PDB:4N0B" /db_xref="PDB:4TV7" /db_xref="PDB:5T4J" /db_xref="PDB:5T4K" /db_xref="PDB:5X03" /db_xref="SubtiList:BG12042" /db_xref="UniProtKB/Swiss-Prot:P94426" /translation="MDITITLDRSEQADYIYQQIYQKLKKEILSRNLLPHSKVPSKRE LAENLKVSVNSVNSAYQQLLAEGYLYAIERKGFFVEELDMFSAEEHPPFALPDDLKEI HIDQSDWISFSHMSSDTDHFPIKSWFRCEQKAASRSYRTLGDMSHPQGIYEVRAAITR LISLTRGVKCRPEQMIIGAGTQVLMQLLTELLPKEAVYAMEEPGYRRMYQLLKNAGKQ VKTIMLDEKGMSIAEITRQQPDVLVTTPSHQFPSGTIMPVSRRIQLLNWAAEEPRRYI IEDDYDSEFTYDVDSIPALQSLDRFQNVIYMGTFSKSLLPGLRISYMVLPPELLRAYK QRGYDLQTCSSLTQLTLQEFIESGEYQKHIKKMKQHYKEKRERLITALEAEFSGEVTV KGANAGLHFVTEFDTRRTEQDILSHAAGLQLEIFGMSRFNLKENKRQTGRPALIIGFA RLKEEDIQEGVQRLFKAVYGHKKIPVTGD*" /label="gabR CDS" gene complement(421592..423031) /gene="gabR" /locus_tag="BSU_03890" /old_locus_tag="BSU03890" /label="gabR gene" promotor_-10 complement(421916..421927) /Source="Nicolas_upshift_promotors" /id="U298" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=919 /SigmaFactorBS="cctgcaggaatttatcgagtctggtgaatatcagaAGCATAT aaaaaaaatgaagCAGCATTATAAAgaaaagagagaacgcctgatcaccgctttagaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(421922) /Source="Nicolas_upshifts" /id="U298" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=919 /SigmaFactorBS="cctgcaggaatttatcgagtctggtgaatatcagaAGCATAT aaaaaaaatgaagCAGCATTATAAAgaaaagagagaacgcctgatcaccgctttagaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(421941..421947) /Source="Nicolas_upshift_promotors" /id="U298" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=919 /SigmaFactorBS="cctgcaggaatttatcgagtctggtgaatatcagaAGCATAT aaaaaaaatgaagCAGCATTATAAAgaaaagagagaacgcctgatcaccgctttagaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(423074..423093) /Source="Nicolas_upshift_promotors" /id="U299" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.728271728271728" /psig="0.999000999001" /xcortree=2992 /SigmaFactorBS="tcatgtgaatatccccctgtcggtattttcTTATCATTctga cttctcTTTGGTATGATGAAAAGTACcaattataactttttgatggtatcagaaggag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 423075..423082 /Source="Nicolas_upshift_promotors" /id="U300" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.537462537462537" /psig="0.942057942057942" /xcortree=377 /SigmaFactorBS="ttctccttctgataccatcaaaaagttataattggTACTTTT CatcataccaaagaGAAGTCAGAATGATAAGAAAataccgacagggggatattcacat g" /listShort="gabT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(423081) /Source="Nicolas_upshifts" /id="U299" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.728271728271728" /psig="0.999000999001" /xcortree=2992 /SigmaFactorBS="tcatgtgaatatccccctgtcggtattttcTTATCATTctga cttctcTTTGGTATGATGAAAAGTACcaattataactttttgatggtatcagaaggag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 423096..423115 /Source="Nicolas_upshift_promotors" /id="U300" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.537462537462537" /psig="0.942057942057942" /xcortree=377 /SigmaFactorBS="ttctccttctgataccatcaaaaagttataattggTACTTTT CatcataccaaagaGAAGTCAGAATGATAAGAAAataccgacagggggatattcacat g" /listShort="gabT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 423100 /Source="Nicolas_upshifts" /id="U300" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.537462537462537" /psig="0.942057942057942" /xcortree=377 /SigmaFactorBS="ttctccttctgataccatcaaaaagttataattggTACTTTT CatcataccaaagaGAAGTCAGAATGATAAGAAAataccgacagggggatattcacat g" /listShort="gabT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(423104..423111) /Source="Nicolas_upshift_promotors" /id="U299" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.728271728271728" /psig="0.999000999001" /xcortree=2992 /SigmaFactorBS="tcatgtgaatatccccctgtcggtattttcTTATCATTctga cttctcTTTGGTATGATGAAAAGTACcaattataactttttgatggtatcagaaggag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 423138..424448 /gene="gabT" /locus_tag="BSU_03900" /old_locus_tag="BSU03900" /EC_number="2.6.1.19" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:4590473, 12123465, 12354229, 15590624, 9723923, 19854901, 24529384" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4590473, 12123465, 12354229, 15590624, 9723923, 19854901, 24529384; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="4-aminobutyrate aminotransferase" /protein_id="NP_388272.1" /db_xref="EnsemblGenomes-Gn:BSU03900" /db_xref="EnsemblGenomes-Tr:CAB12198" /db_xref="GOA:P94427" /db_xref="InterPro:IPR004632" /db_xref="InterPro:IPR005814" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG12043" /db_xref="UniProtKB/Swiss-Prot:P94427" /translation="MSQTTASITTAQWQQKRDQFVSKGVSNGNRSLAVKGEGAELYDL DGRRFIDFAGAIGTLNVGHSHPKVVEAVKRQAEELIHPGFNVMMYPTYIELAEKLCGI APGSHEKKAIFLNSGAEAVENAVKIARKYTKRQGVVSFTRGFHGRTNMTMSMTSKVKP YKFGFGPFAPEVYQAPFPYYYQKPAGMSDESYDDMVIQAFNDFFIASVAPETVACVVM EPVQGEGGFIIPSKRFVQHVASFCKEHGIVFVADEIQTGFARTGTYFAIEHFDVVPDL ITVSKSLAAGLPLSGVIGRAEMLDAAAPGELGGTYAGSPLGCAAALAVLDIIEEEGLN ERSEEIGKIIEDKAYEWKQEFPFIGDIRRLGAMAAIEIVKDPDTREPDKTKAAAIAAY ANQNGLLLLTAGINGNIIRFLTPLVISDSLLNEGLSILEAGLRA*" /label="gabT CDS" gene 423138..424448 /gene="gabT" /locus_tag="BSU_03900" /old_locus_tag="BSU03900" /label="gabT gene" promotor_-35 424326..424332 /Source="Nicolas_upshift_promotors" /id="U301" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=250 /SigmaFactorBS="cagcagcgatcgcggcctatgcgaatcaaaacGGATTACttt tgctgacagcGGGAATTAACGGTAATATCatccgctttttgacaccgctcgtcatctc a" /listShort="gabD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 424346..424364 /Source="Nicolas_upshift_promotors" /id="U301" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=250 /SigmaFactorBS="cagcagcgatcgcggcctatgcgaatcaaaacGGATTACttt tgctgacagcGGGAATTAACGGTAATATCatccgctttttgacaccgctcgtcatctc a" /listShort="gabD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 424354 /Source="Nicolas_upshifts" /id="U301" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=250 /SigmaFactorBS="cagcagcgatcgcggcctatgcgaatcaaaacGGATTACttt tgctgacagcGGGAATTAACGGTAATATCatccgctttttgacaccgctcgtcatctc a" /listShort="gabD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 424450..424457 /Source="Nicolas_upshift_promotors" /id="U302" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig="0.998001998001998" /xcortree=2034 /SigmaFactorBS="catcttggaggcgggcctgcgagcttaatCATTGGAAagaaa atggccgggTCTGCTATCATTTTAAGTAAtcatgaaaagaaaggaatgttcaatatgc c" /listShort="gabD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 424472..424491 /Source="Nicolas_upshift_promotors" /id="U302" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig="0.998001998001998" /xcortree=2034 /SigmaFactorBS="catcttggaggcgggcctgcgagcttaatCATTGGAAagaaa atggccgggTCTGCTATCATTTTAAGTAAtcatgaaaagaaaggaatgttcaatatgc c" /listShort="gabD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 424481 /Source="Nicolas_upshifts" /id="U302" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig="0.998001998001998" /xcortree=2034 /SigmaFactorBS="catcttggaggcgggcctgcgagcttaatCATTGGAAagaaa atggccgggTCTGCTATCATTTTAAGTAAtcatgaaaagaaaggaatgttcaatatgc c" /listShort="gabD" /GFF_Attribute="listLong" /label="upshifts" CDS 424517..425905 /gene="gabD" /locus_tag="BSU_03910" /old_locus_tag="BSU03910" /EC_number="1.2.1.24" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12354229, 15590624, 9723923, 12123465, 24529384, 24809290, 25911692" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15590624, 9723923, 12123465, 24529384, 24809290, 25911692; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="succinate-semialdehyde dehydrogenase" /protein_id="NP_388273.1" /db_xref="EnsemblGenomes-Gn:BSU03910" /db_xref="EnsemblGenomes-Tr:CAB12199" /db_xref="GOA:P94428" /db_xref="InterPro:IPR010102" /db_xref="InterPro:IPR012394" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016160" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="SubtiList:BG12044" /db_xref="UniProtKB/Swiss-Prot:P94428" /translation="MPDQLTVYNPATGEEIKTIPQQSATEVEEAIERSHQAFKTWSKT SANERTSLLKKWYELIVEHKEELADLITKENGKPYQEAVGEVLYGAGYIEWFAEEAKR VYGRTVPAPTTGKRIVVTRQPVGPVAAITPWNFPNAMITRKAAPALAAGCTFIIKPAP DTPLSAYELARLAYEAGIPKDVLQVVIGDGEEIGNVFTSSPKIRKITFTGSTPVGKIL MKNSADTVKHVSMELGGHAPLIVDEDADIDLAVEQAMASKYRNAGQTCVCANRLIVHE SIKDEFAAKLSEQVSKLKVGNGLEEGVNVGPIINKRGFEKIVSQIDDAVEKGAKVIAG GTYDRNDDKGCYFVNPTVLTDVDTSMNIMHEETFGPVAPIVTFSDIDEAIQLANDTPY GLAAYFFTENYRRGIYISENLEYGIIGWNDGGPSAVQAPFGGMKESGIGREGGSEGIE PYLETKYLSIGL*" /label="gabD CDS" gene 424517..425905 /gene="gabD" /locus_tag="BSU_03910" /old_locus_tag="BSU03910" /label="gabD gene" downshifts 425913 /Source="Nicolas_upshifts" /id="D173" /incds=0 /nref=107 /ntot=240 /MaxReadThrough="0.105510000000001" /MaxDrop="6.52053" /score="38.677658" /energy="-19.9" /TU="NA" /idTUdmin="U301" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" promotor_-35 425963..425969 /Source="Nicolas_upshift_promotors" /id="U303" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=885 /SigmaFactorBS="gagctgccggattttccggcagctctttttgtgttccggCGA ATAAtcacaacaattccAGCCAAAATAACagcaaatacattttgaaagaaggttcccc a" /listShort="glcU, gdh" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 425983..425994 /Source="Nicolas_upshift_promotors" /id="U303" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=885 /SigmaFactorBS="gagctgccggattttccggcagctctttttgtgttccggCGA ATAAtcacaacaattccAGCCAAAATAACagcaaatacattttgaaagaaggttcccc a" /listShort="glcU, gdh" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 425984 /Source="Nicolas_upshifts" /id="U303" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=885 /SigmaFactorBS="gagctgccggattttccggcagctctttttgtgttccggCGA ATAAtcacaacaattccAGCCAAAATAACagcaaatacattttgaaagaaggttcccc a" /listShort="glcU, gdh" /GFF_Attribute="listLong" /label="upshifts" CDS 426028..426891 /gene="glcU" /locus_tag="BSU_03920" /old_locus_tag="BSU03920" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10438764, 15849754, 16850406, 19054326, 21564334, 27329749; Product type t : transporter" /codon_start=1 /transl_table=11 /product="glucose uptake protein" /protein_id="NP_388274.1" /db_xref="EnsemblGenomes-Gn:BSU03920" /db_xref="EnsemblGenomes-Tr:CAB12200" /db_xref="GOA:P40420" /db_xref="InterPro:IPR010651" /db_xref="SubtiList:BG11066" /db_xref="UniProtKB/Swiss-Prot:P40420" /translation="MDLLLALLPALFWGSIVLFNVKLGGGPYSQTLGTTIGALIVSIV IYFFVQPVLSLRIFIVGIVSGLFWSLGQANQLKSIQLMGVSKTMPISTGMQLVSTSLF GVIVFREWSTPIAITLGVLALIFIIVGIILTSLEDKNDKKEGEPSNLKKGILILLVST LGYLVYVVVARLFNVSGWSALLPQAIGMVVGGLVLTYRHKPFNKYAIRNILPGLIWAG GNMFLFISQPRVGVATSFSLSQMGIVISTLGGIFILREKKTKRQLIAIAIGIILIIAA AVFLGIAKTNS*" /label="glcU CDS" gene 426028..426891 /gene="glcU" /locus_tag="BSU_03920" /old_locus_tag="BSU03920" /label="glcU gene" CDS 426911..427696 /gene="gdh" /locus_tag="BSU_03930" /old_locus_tag="BSU03930" /EC_number="1.1.1.47" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:2493633, 3141376, 6438057, 16912926" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2493633, 3141376, 6438057, 16912926; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="forespore glucose 1-dehydrogenase" /protein_id="NP_388275.1" /db_xref="EnsemblGenomes-Gn:BSU03930" /db_xref="EnsemblGenomes-Tr:CAB12201" /db_xref="GOA:P12310" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10545" /db_xref="UniProtKB/Swiss-Prot:P12310" /translation="MYPDLKGKVVAITGAASGLGKAMAIRFGKEQAKVVINYYSNKQD PNEVKEEVIKAGGEAVVVQGDVTKEEDVKNIVQTAIKEFGTLDIMINNAGLENPVPSH EMPLKDWDKVIGTNLTGAFLGSREAIKYFVENDIKGNVINMSSVHEVIPWPLFVHYAA SKGGIKLMTETLALEYAPKGIRVNNIGPGAINTPINAEKFADPKQKADVESMIPMGYI GEPEEIAAVAAWLASKEASYVTGITLFADGGMTQYPSFQAGRG*" /label="gdh CDS" gene 426911..427696 /gene="gdh" /locus_tag="BSU_03930" /old_locus_tag="BSU03930" /label="gdh gene" misc_feature 427016..427035 /Source="Nicolas_upshift_promotors" /id="U304" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.692307692307692" /psig="0.732267732267732" /xcortree=1477 /SigmaFactorBS="gcttcagggctcggaaaggcgatggccattcgcttcggcaag gagcaggcaaaagtggttATCAACTATTATAGTAATAAacaagatccgaacgaggtaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 427016 /Source="Nicolas_upshifts" /id="U304" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.692307692307692" /psig="0.732267732267732" /xcortree=1477 /SigmaFactorBS="gcttcagggctcggaaaggcgatggccattcgcttcggcaag gagcaggcaaaagtggttATCAACTATTATAGTAATAAacaagatccgaacgaggtaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 427104 /Source="Nicolas_upshifts" /id="D174" /incds=1 /nref=1 /ntot=3 /MaxReadThrough="6.44884" /MaxDrop="2.47712" /score="-5.4075438" /energy="-11.7" /TU="U303" /idTUdmin="U301" /TUdmin=1188 /isTUend="FALSE" /label="downshifts" downshifts 427698 /Source="Nicolas_upshifts" /id="D175" /incds=0 /nref=4 /ntot=40 /MaxReadThrough="2.7861" /MaxDrop="4.2307" /score="-5.4075438" /energy="-11.7" /TU="U303" /idTUdmin="U303" /TUdmin="-836" /isTUend="FALSE" /label="downshifts" CDS complement(427741..428355) /gene="cutI" /locus_tag="BSU_03940" /old_locus_tag="BSU03940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 19168619, 22904286, 27010565, 26822828; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative membrane protein involved in copper intake" /protein_id="NP_388276.1" /db_xref="EnsemblGenomes-Gn:BSU03940" /db_xref="EnsemblGenomes-Tr:CAB12202" /db_xref="GOA:P94431" /db_xref="InterPro:IPR012533" /db_xref="SubtiList:BG12045" /db_xref="UniProtKB/Swiss-Prot:P94431" /translation="MLKKIALTLCPAIVGSLLFFTAPASAHVSVKPAESAAGSWETYT MKVPSEKNLPTTKVVLKMPKDVEFQQYEPIPGWKVSTQKHDDKSVSVTWEATDGGIQE GQFQQFTFVAKNPDKAEEAAWDAYQYYKDGSIVEWTGDEDADTPHSITNITSAKQVTD EHGATKTEDDSENSGSSALDITAMVLSAAAIILSVAALVKKKRA*" /label="cutI CDS" gene complement(427741..428355) /gene="cutI" /locus_tag="BSU_03940" /old_locus_tag="BSU03940" /label="cutI gene" downshifts complement(427752) /Source="Nicolas_upshifts" /id="D176" /incds=0 /nref=95 /ntot=219 /MaxReadThrough="0.879290000000001" /MaxDrop="6.67627" /score="21.5633403" /energy="-16" /TU="NA" /idTUdmin="U305" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(428368..429993) /gene="cutJ" /locus_tag="BSU_03950" /old_locus_tag="BSU03950" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15101989, 15849754, 16850406, 19168619, 22904286, 23012364" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15101989, 15849754, 16850406, 19168619, 22904286, 23012364; Product type t : transporter" /codon_start=1 /transl_table=11 /product="copper import permease subunit" /protein_id="NP_388277.2" /db_xref="EnsemblGenomes-Gn:BSU03950" /db_xref="EnsemblGenomes-Tr:CAB12203" /db_xref="GOA:C0SP95" /db_xref="InterPro:IPR007348" /db_xref="InterPro:IPR008457" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR014756" /db_xref="InterPro:IPR032693" /db_xref="InterPro:IPR032694" /db_xref="SubtiList:BG12046" /db_xref="UniProtKB/Swiss-Prot:C0SP95" /translation="MKRNRWWIILLLFLVFLPKTSFAHAYIVKSSPGENSELKSAPAQ VEIEFNEPVEEGFHYIKVYNSNGDRVDTDKTEIKKDNHHIMTVKLKKNLPKDVYRAEW NAVSADGHPVSGVIPFSIGKADGGFSSQKAADSALNPGTAADRAILYTALSLFIGTVF FHLFWYKGKSEQLVKRTRRILTGSIAALGLALLLQLPIQTKANAGGGWGSAFQPGYIR ETLFETAGGSIWIIQAALFVLLALSVIPAIRKNRFSSFGYWTAPLIFFFGLLLAKAFT GHAAVVEEKTVGILMDFLHLTSASIWVGGIAALVLLLSKEWRQPDKTLAWETVRRFSP WALTAVGVILFSGLLNGFFIIRSMDSLFHTAYGQALLVKSGLFVFMLVLGAIHFLLTR KQRRTGISRTLKAEWAIGIAVLITAAVFTSLPSPPEPAPEPFYQTKAIENGQSVSLSI SPNQPGKNVFELRVTDHNGDPVKNIQQITLTVYKTGLSGSENKSTFTLKEKTKGVFQD QNLSINEKGNWKIKVHGLTGDFNEINIMFTKTN*" /label="cutJ CDS" gene complement(428368..429993) /gene="cutJ" /locus_tag="BSU_03950" /old_locus_tag="BSU03950" /label="cutJ gene" CDS complement(430028..430600) /gene="cutR" /locus_tag="BSU_03960" /old_locus_tag="BSU03960" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15101989, 22904286, 23012364" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15101989, 22904286, 23012364; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of copper intake (CutR-Cu(+))" /protein_id="NP_388278.1" /db_xref="EnsemblGenomes-Gn:BSU03960" /db_xref="EnsemblGenomes-Tr:CAB12204" /db_xref="GOA:P94433" /db_xref="InterPro:IPR001034" /db_xref="InterPro:IPR008719" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12047" /db_xref="UniProtKB/Swiss-Prot:P94433" /translation="MLPINRQQHILKWLKEEGSLRISDISARFGVSEMTVYRDVNQLV QSNQVIKTAGGITLPVRTPQTDHMCSYCLKPVNQAHSVQLITVNQDIEQLCCAHCAFL RYADKTEEVSHLICRDFLLQTTVSAGSAYFVVNAELNLHCCQPQAIPFATLDHAERFQ KGFGGAVCTFDQALEDMLQDRKKRCTCTKK*" /label="cutR CDS" gene complement(430028..430600) /gene="cutR" /locus_tag="BSU_03960" /old_locus_tag="BSU03960" /label="cutR gene" promotor_-10 complement(430622..430641) /Source="Nicolas_upshift_promotors" /id="U305" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.944055944055944" /psig="0.999000999001" /xcortree=1591 /SigmaFactorBS="tgttcaacacattttcacattttttatcatccactTACTTGT CtccgtctctaaaaTCCTCTACGCTTAAATAGATcttaatgaagagggtgtatgaatg c" /listShort="ycnK, ycnJ, ycnI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(430637) /Source="Nicolas_upshifts" /id="U305" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.944055944055944" /psig="0.999000999001" /xcortree=1591 /SigmaFactorBS="tgttcaacacattttcacattttttatcatccactTACTTGT CtccgtctctaaaaTCCTCTACGCTTAAATAGATcttaatgaagagggtgtatgaatg c" /listShort="ycnK, ycnJ, ycnI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(430655..430662) /Source="Nicolas_upshift_promotors" /id="U305" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.944055944055944" /psig="0.999000999001" /xcortree=1591 /SigmaFactorBS="tgttcaacacattttcacattttttatcatccactTACTTGT CtccgtctctaaaaTCCTCTACGCTTAAATAGATcttaatgaagagggtgtatgaatg c" /listShort="ycnK, ycnJ, ycnI" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 430722..430741 /Source="Nicolas_upshift_promotors" /id="U306" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.764235764235764" /psig="0.999000999001" /xcortree=2504 /SigmaFactorBS="aaaaatgtgaaaatgtgttgaacagcaacaaaacgaaacaga agggacTCTGGTATAATAGACAGATGgaatagaaagtgaggaataccctatgaaagaa a" /listShort="ycnL" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 430734 /Source="Nicolas_upshifts" /id="U306" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.764235764235764" /psig="0.999000999001" /xcortree=2504 /SigmaFactorBS="aaaaatgtgaaaatgtgttgaacagcaacaaaacgaaacaga agggacTCTGGTATAATAGACAGATGgaatagaaagtgaggaataccctatgaaagaa a" /listShort="ycnL" /GFF_Attribute="listLong" /label="upshifts" CDS 430765..431118 /gene="ycnL" /locus_tag="BSU_03970" /old_locus_tag="BSU03970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 18307109, 27010565; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative reductase or disulfide isomerase" /protein_id="NP_388279.1" /db_xref="EnsemblGenomes-Gn:BSU03970" /db_xref="EnsemblGenomes-Tr:CAB12205" /db_xref="GOA:P94434" /db_xref="SubtiList:BG12048" /db_xref="UniProtKB/Swiss-Prot:P94434" /translation="MKETPCPNCGKPLTGDMVRSSNVPCQFRCGHCRERLYEYKVSAP IMLVSLAAIVLLIYLLMLLRNAAGSVLPAVQHVPMAVFALVCAYPVFIVSERMIAKYV IQNGNIIYRGKRKGS*" /label="ycnL CDS" gene 430765..431118 /gene="ycnL" /locus_tag="BSU_03970" /old_locus_tag="BSU03970" /label="ycnL gene" downshifts 431089 /Source="Nicolas_upshifts" /id="D177" /incds=0 /nref=136 /ntot=248 /MaxReadThrough="0.860829999999999" /MaxDrop="6.25982" /score="38.4886131" /energy="-13.4" /TU="NA" /idTUdmin="U306" /TUdmin="-19" /isTUend="TRUE" /label="downshifts" promotor_-35 431182..431189 /Source="Nicolas_upshift_promotors" /id="U307" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1546 /SigmaFactorBS="tgtcacagtcatgtgccaaagtcctctttactttCAATTGTA tagggactgtaagCGTTTTAACATAGAGTCAAAgggaagcatcattctctgaacatat t" /listShort="S132, mtlA, mtlF, mtlD, ycsA, sipU, S133" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 431203..431222 /Source="Nicolas_upshift_promotors" /id="U307" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1546 /SigmaFactorBS="tgtcacagtcatgtgccaaagtcctctttactttCAATTGTA tagggactgtaagCGTTTTAACATAGAGTCAAAgggaagcatcattctctgaacatat t" /listShort="S132, mtlA, mtlF, mtlD, ycsA, sipU, S133" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 431208 /Source="Nicolas_upshifts" /id="U307" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1546 /SigmaFactorBS="tgtcacagtcatgtgccaaagtcctctttactttCAATTGTA tagggactgtaagCGTTTTAACATAGAGTCAAAgggaagcatcattctctgaacatat t" /listShort="S132, mtlA, mtlF, mtlD, ycsA, sipU, S133" /GFF_Attribute="listLong" /label="upshifts" S_feature 431218..431290 /Source="Nicolas_S_feature" /locus_tag="new_449651_449723" /HighExp="S0, dia5, Gly, G135, B60, T0.30H, BT, G180, G150, M40t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S132" CDS 431291..432727 /gene="mtlA" /locus_tag="BSU_03981" /old_locus_tag="BSU03981" /EC_number="2.7.1.197" /function="16.1: Circulate" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12897001, 23279188" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12897001, 23279188; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) mannitol-specific enzyme IICB component" /protein_id="NP_388280.2" /db_xref="EnsemblGenomes-Gn:BSU03981" /db_xref="EnsemblGenomes-Tr:CAB12206" /db_xref="GOA:P42956" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR003501" /db_xref="InterPro:IPR004718" /db_xref="InterPro:IPR013011" /db_xref="InterPro:IPR013014" /db_xref="InterPro:IPR029503" /db_xref="InterPro:IPR036095" /db_xref="SubtiList:BG11215" /db_xref="UniProtKB/Swiss-Prot:P42956" /translation="MQQQEQQQGGMKVKVQRFGSYLSGMIMPNIGAFIAWGIITALFI PAGWFPNEQLNTLVSPMITYLLPLLIAYTGGKMIYDHRGGVVGATAAIGVIVGSDIPM FLGAMIMGPLGGYLIKQTDKLFKDKVKQGFEMLINNFTAGIVGAALTILAFYAIGPVV LTLNKLLAAGVEVIVHANLLPVASVFVEPAKVLFLNNAINHGILSPIGIEQASQTGKS ILFLVEANPGPGLGILLAYMFFGKGSSKSTAPGAAIIHFFGGIHEIYFPYILMKPALI LAAIAGGASGLLTFTIFNAGLVAAASPGSIIALMAMTPRGGYFGVLAGVLVAAAVSFI VSAVILKSSKASEEDLAAATEKMQSMKGKKSQAAAALEAEQAKAEEASELSPESVNKI IFACDAGMGSSAMGASILRNKVKKAELDISVTNTAINNLPSDADIVITHKDLTDRAKA KLPNATHISVDNFLNSPKYDELIEKLKK*" /label="mtlA CDS" gene 431291..432727 /gene="mtlA" /locus_tag="BSU_03981" /old_locus_tag="BSU03981" /label="mtlA gene" CDS 432752..433183 /gene="mtlF" /locus_tag="BSU_03982" /old_locus_tag="BSU03982" /EC_number="2.7.1.197" /function="16.1: Circulate" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12897001, 23279188" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12897001, 23279188; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) mannitol-specific enzyme IIA component" /protein_id="YP_003097678.1" /db_xref="EnsemblGenomes-Gn:BSU03982" /db_xref="EnsemblGenomes-Tr:CAX52549" /db_xref="GOA:C0H3V2" /db_xref="InterPro:IPR002178" /db_xref="InterPro:IPR016152" /db_xref="UniProtKB/Swiss-Prot:C0H3V2" /translation="MQVLAKENIKLNQTVSSKEEAIKLAGQTLIDNGYVTEDYISKMF EREETSSTFMGNFIAIPHGTEEAKSEVLHSGISIIQIPEGVEYGEGNTAKVVFGIAGK NNEHLDILSNIAIICSEEENIERLISAKSEEDLIAIFNEVN*" /label="mtlF CDS" gene 432752..433183 /gene="mtlF" /locus_tag="BSU_03982" /old_locus_tag="BSU03982" /label="mtlF gene" CDS 433185..434306 /gene="mtlD" /locus_tag="BSU_03990" /old_locus_tag="BSU03990" /EC_number="1.1.1.17" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12897001, 22014119, 23279188" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12897001, 22014119, 23279188; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="mannitol-1-phosphate 5-dehydrogenase" /protein_id="NP_388281.2" /db_xref="EnsemblGenomes-Gn:BSU03990" /db_xref="EnsemblGenomes-Tr:CAB12207" /db_xref="GOA:P42957" /db_xref="InterPro:IPR000669" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013118" /db_xref="InterPro:IPR013131" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR023027" /db_xref="InterPro:IPR023028" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11216" /db_xref="UniProtKB/Swiss-Prot:P42957" /translation="MIALHFGAGNIGRGFIGALLHHSGYDVVFADVNETMVSLLNEKK EYTVELAEEGRSSEIIGPVSAINSGSQTEELYRLMNEAALITTAVGPNVLKLIAPSIA EGLRRRNTANTLNIIACENMIGGSSFLKKEIYSHLTEAEQKSVSETVGFPNSAVDRIV PIQHHEDPLKVSVEPFFEWVIDESGFKGKTPVINGALFVDDLTPYIERKLFTVNTGHA VTAYVGYQRGLKTVKEAIDHPEIRRVVHSALLETGDYLVKSYGFKQTEHEQYIKKIIG RFENPFISDDVTRVARSPLRKLGENDRLVGPAKKIKEPNALAEGIAAALRFDFTGDPE AVELQALIEEKGYSGVLQEVCGIQSHEPLHAIILKKLNQ*" /label="mtlD CDS" gene 433185..434306 /gene="mtlD" /locus_tag="BSU_03990" /old_locus_tag="BSU03990" /label="mtlD gene" downshifts 434289 /Source="Nicolas_upshifts" /id="D178" /incds=0 /nref=46 /ntot=156 /MaxReadThrough="5.56503" /MaxDrop="4.72154" /score="32.3837677" /energy="-13.4" /TU="U307" /idTUdmin="U308" /TUdmin="-1254" /isTUend="FALSE" /label="downshifts" promotor_-35 434335..434338 /Source="Nicolas_upshift_promotors" /id="U308" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.964035964035964" /psig=1 /xcortree=1552 /SigmaFactorBS="ttaatcaataaccgaccacccgtgacacaatgtcacgggCTT TttttactatctcgcaATCTAGTATAATAGAAAGCGcttacgataacaggggaaggag a" /listShort="ycsA" /listLong="sipU, S133, ycsD" /label="promotor_-35" promotor_-10 434354..434373 /Source="Nicolas_upshift_promotors" /id="U308" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.964035964035964" /psig=1 /xcortree=1552 /SigmaFactorBS="ttaatcaataaccgaccacccgtgacacaatgtcacgggCTT TttttactatctcgcaATCTAGTATAATAGAAAGCGcttacgataacaggggaaggag a" /listShort="ycsA" /listLong="sipU, S133, ycsD" /label="promotor_-10" upshifts 434356 /Source="Nicolas_upshifts" /id="U308" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.964035964035964" /psig=1 /xcortree=1552 /SigmaFactorBS="ttaatcaataaccgaccacccgtgacacaatgtcacgggCTT TttttactatctcgcaATCTAGTATAATAGAAAGCGcttacgataacaggggaaggag a" /listShort="ycsA" /listLong="sipU, S133, ycsD" /label="upshifts" CDS 434397..435461 /gene="ycsA" /locus_tag="BSU_04000" /old_locus_tag="BSU04000" /EC_number="1.1.1.93" /EC_number="1.1.1.83" /EC_number="4.1.1.73" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10568751, 12356321; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative tartrate dehydrogenase" /protein_id="NP_388282.3" /db_xref="EnsemblGenomes-Gn:BSU04000" /db_xref="EnsemblGenomes-Tr:CAB12208" /db_xref="GOA:P42958" /db_xref="InterPro:IPR011829" /db_xref="InterPro:IPR019818" /db_xref="InterPro:IPR024084" /db_xref="SubtiList:BG11222" /db_xref="UniProtKB/Swiss-Prot:P42958" /translation="MTMKQFEIAAIPGDGVGKEVVAAAEKVLHTAAEVHGGLSFSFTA FPWSCDYYLEHGKMMPEDGIHTLTQFEAVFLGAVGNPKLVPDHISLWGLLLKIRRELE LSINMRPAKQMAGITSPLLHPNDFDFVVIRENSEGEYSEVGGRIHRGDDEIAIQNAVF TRKATERVMRFAFELAKKRRSHVTSATKSNGIYHAMPFWDEVFQQTAADYSGIETSSQ HIDALAAFFVTRPETFDVIVASNLFGDILTDISSSLMGSIGIAPSANINPSGKYPSMF EPVHGSAPDIAGQGLANPIGQIWTAKLMLDHFGEEELGAKILDVMEQVTADGIKTRDI GGQSTTAEVTDEICSRLRKL*" /label="ycsA CDS" gene 434397..435461 /gene="ycsA" /locus_tag="BSU_04000" /old_locus_tag="BSU04000" /label="ycsA gene" promotor_-35 434631..434639 /Source="Nicolas_upshift_promotors" /id="U309" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.96903096903097" /psig="0.96903096903097" /xcortree=1234 /SigmaFactorBS="atttgaagcagtttttttgggagctgtcGGAAATCCGaagct ggttcccgATCATATATCGTTATGGGGGctgctgctgaaaatccggagggagcttgag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 434653..434672 /Source="Nicolas_upshift_promotors" /id="U309" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.96903096903097" /psig="0.96903096903097" /xcortree=1234 /SigmaFactorBS="atttgaagcagtttttttgggagctgtcGGAAATCCGaagct ggttcccgATCATATATCGTTATGGGGGctgctgctgaaaatccggagggagcttgag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 434663 /Source="Nicolas_upshifts" /id="U309" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.96903096903097" /psig="0.96903096903097" /xcortree=1234 /SigmaFactorBS="atttgaagcagtttttttgggagctgtcGGAAATCCGaagct ggttcccgATCATATATCGTTATGGGGGctgctgctgaaaatccggagggagcttgag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 435455 /Source="Nicolas_upshifts" /id="D179" /incds=0 /nref=7 /ntot=41 /MaxReadThrough="4.24123" /MaxDrop="4.42639" /score="9.70532694" /energy="-11.6" /TU="U307,U308" /idTUdmin="U308" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" promotor_-35 435528..435535 /Source="Nicolas_upshift_promotors" /id="U310" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.567432567432567" /psig="0.996003996003996" /xcortree=2303 /SigmaFactorBS="atttccttacgaaaatttccacgaaagTCTAACCAagcagat ccaaaTGCTGTATAATAATTTGGAAttcttaggaaagcatcgggtgaaggaagttgaa t" /listShort="sipU, S133, ycsD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 435548..435567 /Source="Nicolas_upshift_promotors" /id="U310" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.567432567432567" /psig="0.996003996003996" /xcortree=2303 /SigmaFactorBS="atttccttacgaaaatttccacgaaagTCTAACCAagcagat ccaaaTGCTGTATAATAATTTGGAAttcttaggaaagcatcgggtgaaggaagttgaa t" /listShort="sipU, S133, ycsD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 435561 /Source="Nicolas_upshifts" /id="U310" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.567432567432567" /psig="0.996003996003996" /xcortree=2303 /SigmaFactorBS="atttccttacgaaaatttccacgaaagTCTAACCAagcagat ccaaaTGCTGTATAATAATTTGGAAttcttaggaaagcatcgggtgaaggaagttgaa t" /listShort="sipU, S133, ycsD" /GFF_Attribute="listLong" /label="upshifts" CDS 435596..436159 /gene="sipU" /locus_tag="BSU_04010" /old_locus_tag="BSU04010" /EC_number="3.4.21.89" /function="16.1: Circulate" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9325333, 10198007, 11856304, 14568161" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9325333, 10198007, 11856304, 14568161; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="type I signal peptidase" /protein_id="NP_388283.1" /db_xref="EnsemblGenomes-Gn:BSU04010" /db_xref="EnsemblGenomes-Tr:CAB12209" /db_xref="GOA:P42959" /db_xref="InterPro:IPR000223" /db_xref="InterPro:IPR015927" /db_xref="InterPro:IPR019756" /db_xref="InterPro:IPR019757" /db_xref="InterPro:IPR019758" /db_xref="InterPro:IPR036286" /db_xref="SubtiList:BG11223" /db_xref="UniProtKB/Swiss-Prot:P42959" /translation="MNAKTITLKKKRKIKTIVVLSIIMIAALIFTIRLVFYKPFLIEG SSMAPTLKDSERILVDKAVKWTGGFHRGDIIVIHDKKSGRSFVKRLIGLPGDSIKMKN DQLYINDKKVEEPYLKEYKQEVKESGVTLTGDFEVEVPSGKYFVMGDNRLNSLDSRNG MGMPSEDDIIGTESLVFYPFGEMRQAK*" /label="sipU CDS" gene 435596..436159 /gene="sipU" /locus_tag="BSU_04010" /old_locus_tag="BSU04010" /label="sipU gene" S_feature 436160..436884 /Source="Nicolas_S_feature" /locus_tag="new_454593_455317" /HighExp="G150, Oxctl, Lbexp, G135, Paraq, dia0, LBGexp, Mt0, G180, dia15" /AntisenseName="yczH" /AntisenseCor="0.134432865921808" /AntisenseRegPval="-1.6" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.996, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S133" CDS complement(436219..436827) /gene="yczH" /locus_tag="BSU_04020" /old_locus_tag="BSU04020" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_388284.2" /db_xref="EnsemblGenomes-Gn:BSU04020" /db_xref="EnsemblGenomes-Tr:CAB12210" /db_xref="GOA:O31482" /db_xref="InterPro:IPR002925" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12782" /db_xref="UniProtKB/Swiss-Prot:O31482" /translation="MFPKPLVILAHEIYGVNSHMKKMGRLIKMAGYDVLTPNLLGEDE VYTLKEEKTAYEQFTKHERLKTGETIIQNVIRQNAGRHIFVIGFSVGATIAWKCSSMP EVSGSVCYYGSRIRDSLHHMPACPVLLFFPNYEPSFDVALLIKKLREKQHTHLEIYQF DALHGFANPDSVYFNRALFFKTLSIIKNGAESRLRTVSSSFF*" /label="yczH CDS" gene complement(436219..436827) /gene="yczH" /locus_tag="BSU_04020" /old_locus_tag="BSU04020" /label="yczH gene" misc_feature complement(436845..436864) /Source="Nicolas_upshift_promotors" /id="U311" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.397602397602398" /psig="0.993006993006993" /xcortree=2931 /SigmaFactorBS="aagataatgagttcattttatatctcctttttttgaccatta tatctcagcctaaagtgaaacgATAGGATATAATGGAAAAAAcacaaaaggaggccgt t" /listShort="yczH" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-35 436861..436867 /Source="Nicolas_upshift_promotors" /id="U312" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.572427572427572" /psig="0.995004995004995" /xcortree=3001 /SigmaFactorBS="ataacggcctccttttgtgttttttccattatatcCTATCGT ttcactttaggcTGAGATATAATGGTCAAAAAaaggagatataaaatgaactcattat c" /listShort="ycsD" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(436868) /Source="Nicolas_upshifts" /id="U311" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.397602397602398" /psig="0.993006993006993" /xcortree=2931 /SigmaFactorBS="aagataatgagttcattttatatctcctttttttgaccatta tatctcagcctaaagtgaaacgATAGGATATAATGGAAAAAAcacaaaaggaggccgt t" /listShort="yczH" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 436880..436899 /Source="Nicolas_upshift_promotors" /id="U312" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.572427572427572" /psig="0.995004995004995" /xcortree=3001 /SigmaFactorBS="ataacggcctccttttgtgttttttccattatatcCTATCGT ttcactttaggcTGAGATATAATGGTCAAAAAaaggagatataaaatgaactcattat c" /listShort="ycsD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 436886 /Source="Nicolas_upshifts" /id="U312" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.572427572427572" /psig="0.995004995004995" /xcortree=3001 /SigmaFactorBS="ataacggcctccttttgtgttttttccattatatcCTATCGT ttcactttaggcTGAGATATAATGGTCAAAAAaaggagatataaaatgaactcattat c" /listShort="ycsD" /GFF_Attribute="listLong" /label="upshifts" CDS 436913..437305 /gene="ycsD" /locus_tag="BSU_04030" /old_locus_tag="BSU04030" /EC_number="4.2.1.-" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12682299, 16291680, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydroxyacyl-(acyl carrier protein) dehydratase" /protein_id="NP_388285.2" /db_xref="EnsemblGenomes-Gn:BSU04030" /db_xref="EnsemblGenomes-Tr:CAB12211" /db_xref="InterPro:IPR013114" /db_xref="InterPro:IPR029069" /db_xref="SubtiList:BG11225" /db_xref="UniProtKB/Swiss-Prot:P42961" /translation="MNSLSLPHRYPFLFIDGVTDSEPGKHAAAYKLISENDWFITDTQ TEMPFSLVIEALAQTAAFTGITDENSLGLLSSVKKAEKLGEAVPGDRLDLTFEVTRNR RGFVFGHAKASVGEQPVAEAEIGIYIEK*" /label="ycsD CDS" gene 436913..437305 /gene="ycsD" /locus_tag="BSU_04030" /old_locus_tag="BSU04030" /label="ycsD gene" downshifts 437282 /Source="Nicolas_upshifts" /id="D180" /incds=0 /nref=23 /ntot=189 /MaxReadThrough="1.8721" /MaxDrop="3.42324" /score="-5.4921522" /energy="-13.6" /TU="NA" /idTUdmin="U310" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(437338..437502) /gene="yczO" /locus_tag="BSU_04039" /old_locus_tag="BSU04039" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097679.1" /db_xref="EnsemblGenomes-Gn:BSU04039" /db_xref="EnsemblGenomes-Tr:CAX52550" /db_xref="UniProtKB/Swiss-Prot:C0H3V3" /translation="MTEKKQQNKPNENPEHNDLTDPIPNEELKENMNDEKHKRQQRDN SQSERDYDTK*" /label="yczO CDS" gene complement(437338..437502) /gene="yczO" /locus_tag="BSU_04039" /old_locus_tag="BSU04039" /label="yczO gene" downshifts complement(437358) /Source="Nicolas_upshifts" /id="D181" /incds=0 /nref=101 /ntot=193 /MaxReadThrough="1.44096" /MaxDrop="6.55741" /score="22.582242" /energy="-10.6" /TU="NA" /idTUdmin="U313" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(437512..437530) /Source="Nicolas_upshift_promotors" /id="U313" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=206 /SigmaFactorBS="ttctaatacattatacccagcgggacaaaaaagcgatttcct aTGTTTGAggagaatgaataagAGGAAAACAAACGGTGAGGtgatcaaacatgacaga a" /listShort="yczO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(437534) /Source="Nicolas_upshifts" /id="U313" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=206 /SigmaFactorBS="ttctaatacattatacccagcgggacaaaaaagcgatttcct aTGTTTGAggagaatgaataagAGGAAAACAAACGGTGAGGtgatcaaacatgacaga a" /listShort="yczO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(437545..437551) /Source="Nicolas_upshift_promotors" /id="U313" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=206 /SigmaFactorBS="ttctaatacattatacccagcgggacaaaaaagcgatttcct aTGTTTGAggagaatgaataagAGGAAAACAAACGGTGAGGtgatcaaacatgacaga a" /listShort="yczO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 437564..437571 /Source="Nicolas_upshift_promotors" /id="U314" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.809190809190809" /psig=1 /xcortree=2352 /SigmaFactorBS="cctcttattcattctcctcaaacataggaaatcgctTTTTTG TCccgctgggtataaTGTATTAGAATAGAGAGAAGcacaacaaaaagataaagagagg t" /listShort="ycsE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 437585..437604 /Source="Nicolas_upshift_promotors" /id="U314" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.809190809190809" /psig=1 /xcortree=2352 /SigmaFactorBS="cctcttattcattctcctcaaacataggaaatcgctTTTTTG TCccgctgggtataaTGTATTAGAATAGAGAGAAGcacaacaaaaagataaagagagg t" /listShort="ycsE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 437588 /Source="Nicolas_upshifts" /id="U314" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.809190809190809" /psig=1 /xcortree=2352 /SigmaFactorBS="cctcttattcattctcctcaaacataggaaatcgctTTTTTG TCccgctgggtataaTGTATTAGAATAGAGAGAAGcacaacaaaaagataaagagagg t" /listShort="ycsE" /GFF_Attribute="listLong" /label="upshifts" CDS 437635..438384 /gene="ribZ" /locus_tag="BSU_04040" /old_locus_tag="BSU04040" /EC_number="3.1.3.-" /function="4.9: Riboflavin, FMN, and FAD" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 26316208, 27435445, 27784292; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5-amino-6-ribitylamino-2,4(1H, 3H)-pyrimidinedione 5'-phosphate phosphatase / 5' nucleotidase" /protein_id="NP_388286.2" /db_xref="EnsemblGenomes-Gn:BSU04040" /db_xref="EnsemblGenomes-Tr:CAB12212" /db_xref="GOA:P42962" /db_xref="InterPro:IPR006379" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG11226" /db_xref="UniProtKB/Swiss-Prot:P42962" /translation="MSVQREDVDIKLIAIDMDGTLLNDEQLISDENRKAIREAEDKGV YVVISTGRTLMTCRELAESLKLSSFLITANGSEIWDSNFNLVERKLLHTDHIQMMWDL RNKHNTNFWASTVNKVWRGEFPENITDHEWLKFGFDIEDDDIRNEVLEELRKNKELEI TNSSPTNIEVNALGINKAAALAKVTEKLGFTMENVMAMGDSLNDIAMIKEAGLGVAMG NAQDIVKETADYITDTNIEDGVAKAIRHWVL*" /label="ribZ CDS" gene 437635..438384 /gene="ribZ" /locus_tag="BSU_04040" /old_locus_tag="BSU04040" /label="ribZ gene" downshifts 438361 /Source="Nicolas_upshifts" /id="D182" /incds=0 /nref=219 /ntot=253 /MaxReadThrough="3.23506" /MaxDrop="6.84998" /score="19.5535298" /energy="-11.7" /TU="NA" /idTUdmin="U314" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" downshifts complement(438437) /Source="Nicolas_upshifts" /id="D183" /incds=0 /nref=1 /ntot=7 /MaxReadThrough="0.52326" /MaxDrop="2.84763" /score="25.9755124" /energy="-11.7" /TU="NA" /idTUdmin="U313" /TUdmin="-1079" /isTUend="FALSE" /label="downshifts" promotor_-35 438467..438473 /Source="Nicolas_upshift_promotors" /id="U315" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.386613386613387" /psig="0.996003996003996" /xcortree=2194 /SigmaFactorBS="attctgggaccatggtaggttttctgacaaaagtATTTCACa aactgatatgatTCACTTATAATGAAATAAAGttcaaaaattcggaatagtcgttccg a" /listShort="S134, ycsF, ycsG, ycsI, kipI, kipA, kipR, lipC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 438487..438506 /Source="Nicolas_upshift_promotors" /id="U315" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.386613386613387" /psig="0.996003996003996" /xcortree=2194 /SigmaFactorBS="attctgggaccatggtaggttttctgacaaaagtATTTCACa aactgatatgatTCACTTATAATGAAATAAAGttcaaaaattcggaatagtcgttccg a" /listShort="S134, ycsF, ycsG, ycsI, kipI, kipA, kipR, lipC" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 438493..438589 /Source="Nicolas_S_feature" /locus_tag="new_456926_457022" /HighExp="S1, Cold, S0, GM 5, BMM, MG 25, Lbtran, aero, GM 10, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S134" upshifts 438493 /Source="Nicolas_upshifts" /id="U315" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.386613386613387" /psig="0.996003996003996" /xcortree=2194 /SigmaFactorBS="attctgggaccatggtaggttttctgacaaaagtATTTCACa aactgatatgatTCACTTATAATGAAATAAAGttcaaaaattcggaatagtcgttccg a" /listShort="S134, ycsF, ycsG, ycsI, kipI, kipA, kipR, lipC" /GFF_Attribute="listLong" /label="upshifts" CDS 438590..439363 /gene="pxpA" /locus_tag="BSU_04050" /old_locus_tag="BSU04050" /EC_number="3.5.2.9" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9334321, 28830929" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9334321, 28830929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="oxoprolinase subunit A" /protein_id="NP_388287.3" /db_xref="EnsemblGenomes-Gn:BSU04050" /db_xref="EnsemblGenomes-Tr:CAB12213" /db_xref="GOA:P42963" /db_xref="InterPro:IPR005501" /db_xref="InterPro:IPR011330" /db_xref="SubtiList:BG11227" /db_xref="UniProtKB/Swiss-Prot:P42963" /translation="MFQIDLNCDLGESFGAYKIGLDQDILEYVTSANIACGFHAGDPS VMRKTVALAAERGVKMGAHPGLPDLLGFGRRNMAISPEEAYDLVVYQIGALSGFLKAE GLHMQHVKPHGALYNMAAVDQKLSDAIAKAVYKVDPGLILFGLAESELVKAGERIGLQ TANEVFADRTYQSDGTLTPRSQPDALIESDDAAVTQVIKMVKEGAVKSQQGHDVSLKA DTVCIHGDGAHALTFAQKIRKQLKAAGIEVTAISEQRST*" /label="pxpA CDS" gene 438590..439363 /gene="pxpA" /locus_tag="BSU_04050" /old_locus_tag="BSU04050" /label="pxpA gene" CDS 439378..440592 /gene="pxpG" /locus_tag="BSU_04060" /old_locus_tag="BSU04060" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 9334321, 15849754, 16850406, 28830929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5-oxoproline transporter" /protein_id="NP_388288.3" /db_xref="EnsemblGenomes-Gn:BSU04060" /db_xref="EnsemblGenomes-Tr:CAB12214" /db_xref="GOA:P42964" /db_xref="InterPro:IPR001046" /db_xref="SubtiList:BG11228" /db_xref="UniProtKB/Swiss-Prot:P42964" /translation="MEQQKKTAGKKAGSWSLLMGAAFLMATSAIGPGFLTQTATFTNT LAASFGFVILISIILDIFAQTNVWRIIAVSGKRGQEIANMVLPGLGYFIAILVVLGGL AFNIGNIGGAGLGLQVLFGITPETGALISAVIAILIFVIKEAGKAMDRFTQIAGFVMI ILTVYVAATTAPPVGQAVANTFVPEHISIFAIVTLVGGTVGGYITFAGGHRLLDAGIK GKESIPQVTKSSVVGILITSVMRIALFLAVLGVVSKGLHIDESNPAASVFKLAAGNVG YKIFGLIMWSAAITSVIGAAYTSVSFFKTFSPKIEKNSRGIIIGFIVVSTLAFVTIGQ PAKILVLVGSLNGLILPIALGTLLVAAYKKNIVGDYKHPLWLTSTGALVVIVMAVMGI YTLCTQLPQLWS*" /label="pxpG CDS" gene 439378..440592 /gene="pxpG" /locus_tag="BSU_04060" /old_locus_tag="BSU04060" /label="pxpG gene" CDS 440616..441389 /gene="pxpI" /locus_tag="BSU_04070" /old_locus_tag="BSU04070" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8186229, 9334321, 28830929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative D-5-oxoproline epimerase" /protein_id="NP_388289.3" /db_xref="EnsemblGenomes-Gn:BSU04070" /db_xref="EnsemblGenomes-Tr:CAB12215" /db_xref="GOA:P42966" /db_xref="InterPro:IPR009906" /db_xref="InterPro:IPR016938" /db_xref="SubtiList:BG11230" /db_xref="UniProtKB/Swiss-Prot:P42966" /translation="MAPKDVRALIREGKINGPTAGMSGGYAQANLVVLKKDLAFDFLL FCQRNQKPCPVLDVTEAGSPVPSLAAPDADIRTDFPKYRIYRHGILTEEVSDITPYWE DDFVGFLIGCSFSFEQALINNGIAVRHIDEGTNVSMYKTNIDCVPAGAFHGQMVVSMR PVPERLAVRAAQVTSRFPAVHGGPIHIGNPGAIGIRDLGKPDFGDAVSIRDGEVPVFW ACGVTPQAVAMNVKPEMVITHAPGHMLITDIRDESLAVL*" /label="pxpI CDS" gene 440616..441389 /gene="pxpI" /locus_tag="BSU_04070" /old_locus_tag="BSU04070" /label="pxpI gene" CDS 441434..442156 /gene="pxpB" /locus_tag="BSU_04080" /old_locus_tag="BSU04080" /EC_number="3.5.2.9" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9334321, 18823995, 19040634, 20524093, 21050859, 21245531, 22277658, 28830929" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9334321, 18823995, 19040634, 20524093, 21050859, 21245531, 22277658, 28830929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-5-oxoprolinase (ATP-dependent) subunit B" /protein_id="NP_388290.2" /db_xref="EnsemblGenomes-Gn:BSU04080" /db_xref="EnsemblGenomes-Tr:CAB12216" /db_xref="GOA:P60495" /db_xref="InterPro:IPR003833" /db_xref="InterPro:IPR010016" /db_xref="InterPro:IPR024946" /db_xref="InterPro:IPR029000" /db_xref="PDB:2KWA" /db_xref="PDB:2ZP2" /db_xref="SubtiList:BG11231" /db_xref="UniProtKB/Swiss-Prot:P60495" /translation="MTVRYQIEQLGDSAMMIRFGEEINEQVNGIVHAAAAYIEEQPFP GFIECIPAFTSLTVFYDMYEVYKHLPQGISSPFESVKRDVEERLAEIAEDYEVNRRIV EIPVCYGGEFGPDLEEVAKINQLSPEEVIDIHTNGEYVVYMLGFAPGFPFLGGMSKRI AAPRKSSPRPSIPAGSVGIAGLQTGVYPISTPGGWQLIGKTPLALFRPQENPPTLLRA GDIVKFVRISEKDYHAYKEESN*" /label="pxpB CDS" gene 441434..442156 /gene="pxpB" /locus_tag="BSU_04080" /old_locus_tag="BSU04080" /label="pxpB gene" CDS 442159..443166 /gene="pxpC" /locus_tag="BSU_04090" /old_locus_tag="BSU04090" /EC_number="3.5.2.9" /function="16.6: Maintain" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9334321, 18823995, 19040634, 20524093, 21050859, 21245531, 22277658, 28830929" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9334321, 18823995, 19040634, 20524093, 21050859, 21245531, 22277658, 28830929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-5-oxoprolinase (ATP-dependent) subunit C" /protein_id="YP_054571.2" /db_xref="EnsemblGenomes-Gn:BSU04090" /db_xref="EnsemblGenomes-Tr:CAE01447" /db_xref="GOA:Q7WY77" /db_xref="InterPro:IPR003778" /db_xref="InterPro:IPR029000" /db_xref="SubtiList:BG14193" /db_xref="UniProtKB/Swiss-Prot:Q7WY77" /translation="MKVLKPGLLTTVQDIGRTGYQKYGVLASGAMDTVSLRIANLLIG NGENEAGLEITMMGPGPSFHFSKQTLIAVTGADFTLRINDEEAPLWKPVLIKENSTVS FGPCKLGSRAYLAAAGGIEVPAVMESKSTYVRGSIGGLHGRALQKEDELNIGEMSALS QTILSRLSSQLGKQGFAAPKWSVSRGRFLPLKKNPVIRVLEGKQFAFFTEESKTRFYE EAFRVTPQSDRMGYRLKGEPLELKAPLEMVSEAVSFGTVQVPPDGNPIILLADRQTTG GYPRIAHIISADLPIVSQIMPGEHVQFEPVSLQEAEALAVEREQHIKELKTRMKMEWL T*" /label="pxpC CDS" gene 442159..443166 /gene="pxpC" /locus_tag="BSU_04090" /old_locus_tag="BSU04090" /label="pxpC gene" downshifts 442652 /Source="Nicolas_upshifts" /id="D184" /incds=1 /nref=6 /ntot=27 /MaxReadThrough="5.04721" /MaxDrop="4.5277" /score="-7.2426149" /energy="-12.4" /TU="U315" /idTUdmin="U315" /TUdmin="-1975" /isTUend="FALSE" /label="downshifts" promotor_no_box 442746..442846 /Source="Nicolas_upshift_promotors" /id="U316" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.645354645354645" /psig="0.020979020979021" /xcortree=1726 /SigmaFactorBS="cattcgggtgctggaaggaaagcaatttgcctttttcacaga agaatcaaaaacgcgtttttatgaagaagcatttcgtgtcacgccgcagtccgaccgt a" /listShort="kipR, lipC" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 442806 /Source="Nicolas_upshifts" /id="U316" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.645354645354645" /psig="0.020979020979021" /xcortree=1726 /SigmaFactorBS="cattcgggtgctggaaggaaagcaatttgcctttttcacaga agaatcaaaaacgcgtttttatgaagaagcatttcgtgtcacgccgcagtccgaccgt a" /listShort="kipR, lipC" /GFF_Attribute="listLong" /label="upshifts" CDS 443182..443934 /gene="pxpR" /locus_tag="BSU_04100" /old_locus_tag="BSU04100" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9334321; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of the pxp operon (IclR family)" /protein_id="NP_388291.2" /db_xref="EnsemblGenomes-Gn:BSU04100" /db_xref="EnsemblGenomes-Tr:CAB12217" /db_xref="GOA:P42968" /db_xref="InterPro:IPR005471" /db_xref="InterPro:IPR014757" /db_xref="InterPro:IPR029016" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11214" /db_xref="UniProtKB/Swiss-Prot:P42968" /translation="MQNKNKTVVKSMALLNLFLHKPSLTLSELVSLTGMPKTSVHRMV SSLEEMGFLSRDASGAYSLGLVFLEFGQLVADRLDIRKIAKPVMEELCREVDEAVQLI MRDGNEAIYVEKIEGTQTVRLYTAIGRRSPLYAGACARSILSFLPREEIEAYIKQTEL ISIGSGTITDPEKLLQEIDASVQNGYTVSYSELENYTAAIGAPIFNHERQVAAGISIA GFEARFTEDRLPYLTEKVKDAALQISRKIGYT*" /label="pxpR CDS" gene 443182..443934 /gene="pxpR" /locus_tag="BSU_04100" /old_locus_tag="BSU04100" /label="pxpR gene" promotor_-35 443932..443941 /Source="Nicolas_upshift_promotors" /id="U317" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1275 /SigmaFactorBS="cagatttcaagaaaaataggatatacaTAAGTAGCCAatctt ttctctgcTGCGTACATTAACGTATCGAcgttcaagagtggaggaaagaacatggtgc t" /listShort="lipC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 443955..443974 /Source="Nicolas_upshift_promotors" /id="U317" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1275 /SigmaFactorBS="cagatttcaagaaaaataggatatacaTAAGTAGCCAatctt ttctctgcTGCGTACATTAACGTATCGAcgttcaagagtggaggaaagaacatggtgc t" /listShort="lipC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 443965 /Source="Nicolas_upshifts" /id="U317" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1275 /SigmaFactorBS="cagatttcaagaaaaataggatatacaTAAGTAGCCAatctt ttctctgcTGCGTACATTAACGTATCGAcgttcaagagtggaggaaagaacatggtgc t" /listShort="lipC" /GFF_Attribute="listLong" /label="upshifts" CDS 443998..444639 /gene="lipC" /locus_tag="BSU_04110" /old_locus_tag="BSU04110" /EC_number="3.1.1.-" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9334321, 17220230, 20057119" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9334321, 17220230, 20057119; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore coat phospholipase B" /protein_id="NP_388292.1" /db_xref="EnsemblGenomes-Gn:BSU04110" /db_xref="EnsemblGenomes-Tr:CAB12218" /db_xref="GOA:P42969" /db_xref="InterPro:IPR013830" /db_xref="InterPro:IPR036514" /db_xref="SubtiList:BG11232" /db_xref="UniProtKB/Swiss-Prot:P42969" /translation="MVLRYTALGDSLTTGRGSGLFSPGFVQRFGDMMEADLKTRTAIN IFARSGLNTEEILGLLSYPYVQKCIRDADMITITGCGNDLIDSVLAYQTSKDETIFSR VSAHCHENFEKMIAKVAEIKGENPSPYAIRVFNLYNPFPEIDIAGKWITSFNSHLETL ASAPHVKIADAYSIFKGKEQEYLSFDGVHPNSKGYQAMAEAVHKLGYKELSVS*" /label="lipC CDS" gene 443998..444639 /gene="lipC" /locus_tag="BSU_04110" /old_locus_tag="BSU04110" /label="lipC gene" downshifts 444625 /Source="Nicolas_upshifts" /id="D185" /incds=0 /nref=106 /ntot=223 /MaxReadThrough="0.550230000000001" /MaxDrop="6.63515" /score="26.7371783" /energy="-11.8" /TU="NA" /idTUdmin="U315" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" S_feature complement(444637..445062) /Source="Nicolas_S_feature" /locus_tag="new_463070_463495_c" /HighExp="S1, Sw, BC, S2, Lbtran, M0t90, LPhT, BI, M40t45, C90" /AntisenseName="yczI" /AntisenseCor="-0.57558682544748696" /AntisenseRegPval="-24.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.965" /TUlongSig="NA" /TUlongPSig="NA" /label="S135" downshifts complement(444682) /Source="Nicolas_upshifts" /id="D186" /incds=0 /nref=171 /ntot=252 /MaxReadThrough="1.91715" /MaxDrop="5.13764" /score="6.4765859" /energy="-11.8" /TU="NA" /idTUdmin="U319" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 444715..444721 /Source="Nicolas_upshift_promotors" /id="U318" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.361638361638362" /psig="0.998001998001998" /xcortree=2779 /SigmaFactorBS="gatcgaaatattaaaagaaacttaaaattctctgtcttcTGT TCTAcagacaaacaaagTGCGCTAGAATAATGGAGGGcgtaggcaaatatagccataa c" /listShort="yczI, S136, pbpC, S137, ycsN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 444735..444754 /Source="Nicolas_upshift_promotors" /id="U318" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.361638361638362" /psig="0.998001998001998" /xcortree=2779 /SigmaFactorBS="gatcgaaatattaaaagaaacttaaaattctctgtcttcTGT TCTAcagacaaacaaagTGCGCTAGAATAATGGAGGGcgtaggcaaatatagccataa c" /listShort="yczI, S136, pbpC, S137, ycsN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 444736 /Source="Nicolas_upshifts" /id="U318" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.361638361638362" /psig="0.998001998001998" /xcortree=2779 /SigmaFactorBS="gatcgaaatattaaaagaaacttaaaattctctgtcttcTGT TCTAcagacaaacaaagTGCGCTAGAATAATGGAGGGcgtaggcaaatatagccataa c" /listShort="yczI, S136, pbpC, S137, ycsN" /GFF_Attribute="listLong" /label="upshifts" CDS 444812..445057 /gene="yczI" /locus_tag="BSU_04120" /old_locus_tag="BSU04120" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388293.1" /db_xref="EnsemblGenomes-Gn:BSU04120" /db_xref="EnsemblGenomes-Tr:CAB12219" /db_xref="GOA:P42970" /db_xref="InterPro:IPR025018" /db_xref="SubtiList:BG12783" /db_xref="UniProtKB/Swiss-Prot:P42970" /translation="MFRIFKMSFAVIIIILALIAFNYTEHTSVIQSVMLVFLGAVMFM QGLEERKKENDGSGAFNIYTAVFVWSVSLIGFTLHII*" /label="yczI CDS" gene 444812..445057 /gene="yczI" /locus_tag="BSU_04120" /old_locus_tag="BSU04120" /label="yczI gene" S_feature 445058..445468 /Source="Nicolas_S_feature" /locus_tag="new_463491_463901" /HighExp="T5.0H, T2.30H, T3.30H, T2.0H, T3.0H, T4.0H, T1.30H, M9-stat, T-4.40H, T-3.40H" /AntisenseName="yczJ" /AntisenseCor="-0.20847541933848601" /AntisenseRegPval="-3.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S136" CDS complement(445063..445350) /gene="yczJ" /locus_tag="BSU_04130" /old_locus_tag="BSU04130" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388294.1" /db_xref="EnsemblGenomes-Gn:BSU04130" /db_xref="EnsemblGenomes-Tr:CAB12220" /db_xref="InterPro:IPR007138" /db_xref="InterPro:IPR011008" /db_xref="SubtiList:BG12784" /db_xref="UniProtKB/Swiss-Prot:O31484" /translation="MVREAAMLHIKEGLEQEFEDAFRQAAPIISGMKGYITHSLSKCM EETHKYLLLVEWETLEDHTEGFRGSSEYQEWKALLHRFYTPFPTVEHFQDV*" /label="yczJ CDS" gene complement(445063..445350) /gene="yczJ" /locus_tag="BSU_04130" /old_locus_tag="BSU04130" /label="yczJ gene" misc_feature complement(445371..445390) /Source="Nicolas_upshift_promotors" /id="U319" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.542457542457542" /psig="0.965034965034965" /xcortree=1595 /SigmaFactorBS="aagatttttttgaaaatgaaggaaaagttcaccgattttgca gaaatctcctatcgtTTGCTGTAGACTATTTGAAAagacagaaagaagggatagcatg g" /listShort="yczJ, S135" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(445387) /Source="Nicolas_upshifts" /id="U319" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.542457542457542" /psig="0.965034965034965" /xcortree=1595 /SigmaFactorBS="aagatttttttgaaaatgaaggaaaagttcaccgattttgca gaaatctcctatcgtTTGCTGTAGACTATTTGAAAagacagaaagaagggatagcatg g" /listShort="yczJ, S135" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 445444..445448 /Source="Nicolas_upshift_promotors" /id="U320" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.855144855144855" /psig="0.946053946053946" /xcortree=2681 /SigmaFactorBS="aaatcggtgaacttttccttcattttcaaaaaaaTCTTGcac gcaccaattcaatTAAGAGAAAATAACAAGTGGaaggcaggggaaagtcatgttaaaa a" /listShort="pbpC, S137, ycsN, S138, mtlR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 445465..445484 /Source="Nicolas_upshift_promotors" /id="U320" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.855144855144855" /psig="0.946053946053946" /xcortree=2681 /SigmaFactorBS="aaatcggtgaacttttccttcattttcaaaaaaaTCTTGcac gcaccaattcaatTAAGAGAAAATAACAAGTGGaaggcaggggaaagtcatgttaaaa a" /listShort="pbpC, S137, ycsN, S138, mtlR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 445470 /Source="Nicolas_upshifts" /id="U320" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.855144855144855" /psig="0.946053946053946" /xcortree=2681 /SigmaFactorBS="aaatcggtgaacttttccttcattttcaaaaaaaTCTTGcac gcaccaattcaatTAAGAGAAAATAACAAGTGGaaggcaggggaaagtcatgttaaaa a" /listShort="pbpC, S137, ycsN, S138, mtlR" /GFF_Attribute="listLong" /label="upshifts" CDS 445501..447507 /gene="pbpC" /locus_tag="BSU_04140" /old_locus_tag="BSU04140" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8830698, 10648534" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8830698, 10648534; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="penicillin-binding lipoprotein 3; transpeptidase" /protein_id="NP_388295.1" /db_xref="EnsemblGenomes-Gn:BSU04140" /db_xref="EnsemblGenomes-Tr:CAB12221" /db_xref="GOA:P42971" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR005311" /db_xref="InterPro:IPR007887" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR032710" /db_xref="InterPro:IPR036138" /db_xref="SubtiList:BG11234" /db_xref="UniProtKB/Swiss-Prot:P42971" /translation="MLKKCILLVFLCVGLIGLIGCSKTDSPEDRMEAFVKQWNDQQFD DMYQSLTKDVKKEISKKDFVNRYKAIYEQAGVKNLKVTAGEVDKDDQDNKTMKHIPYK VSMNTNAGKVSFKNTAVLKLEKTDDEESWNIDWDPSFIFKQLADDKTVQIMSIEPKRG QIYDKNGKGLAVNTDVPEIGIVPGELGDKKEKVIKELAKKLDLTEDDIKKKLDQGWVK DDSFVPLKKVKPDQEKLVSEATSLQGVTRTNVSSRYYPYGEKTAHLTGYVRAITAEEL KKKKEGTYSDTSNIGIAGLENVYEDKLRGTTGWKIYVPQTGEVIAEKKAKDGEDLHLT IDIKTQMKLYDELKDDSGAAVALQPKTGETLALVSAPSYDPNGFIFGWSDKEWKKLNK DKNNPFSAKFNKTYAPGSTIKPIAAAIGIKNGTLKADEKKTIKGKEWQKDSSWGGYSV TRVSERLQQVDLENALITSDNIYFAQNALDMGADTFTKGLKTFGFSEDVPYEFPIQKS SIANDKLDSDILLADTGYGQGQMQMSPLHLATAYTPFVDNGDLVKPTLIKKDSQTADV WHKQVVTKEGAADITKGLKGVVEDERGSAYQPVVKGITVAGKTGTAELKTSKDDKDGT ENGWFVGYDYENKDLLVAMMIQNVQDRGGSHYVVEKAKKQFQSN*" /label="pbpC CDS" gene 445501..447507 /gene="pbpC" /locus_tag="BSU_04140" /old_locus_tag="BSU04140" /label="pbpC gene" S_feature 447508..447608 /Source="Nicolas_S_feature" /locus_tag="new_465941_466041" /HighExp="LBGstat, T5.0H, M0t45, T3.30H, S0, LBGtran, Oxctl, T4.0H, C30, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.946, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S137" CDS 447609..448511 /gene="ycsN" /locus_tag="BSU_04150" /old_locus_tag="BSU04150" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388296.1" /db_xref="EnsemblGenomes-Gn:BSU04150" /db_xref="EnsemblGenomes-Tr:CAB12222" /db_xref="GOA:P42972" /db_xref="InterPro:IPR020471" /db_xref="InterPro:IPR023210" /db_xref="InterPro:IPR036812" /db_xref="SubtiList:BG11235" /db_xref="UniProtKB/Swiss-Prot:P42972" /translation="MQRIQLAEDLQFSRVIHGLWRLNEWNYSDAELLSLIEWCIDHGI TTFDHADIYGGYTCEKLFGNALALSPGLRENIELVTKCGIVLESPERPAHRSHHYNTS KSHILASVEQSLMNLRTDYIDMLLIHRPDPLMDPEGVAEAFQALKCSGKVRYFGVSNF KDHQYRMLESYLPEKLVTNQIELSAYELENMLDGTLNLCQEKRIPPMAWSPLAGGKVF TENTDKDRRVRTALESVQGEIGAASLDEVMYAWLYTHPAGIMPIVGSGKRERISAAIN ALSYKLDQDQWFRIFTAVQGYDIP*" /label="ycsN CDS" gene 447609..448511 /gene="ycsN" /locus_tag="BSU_04150" /old_locus_tag="BSU04150" /label="ycsN gene" downshifts 448491 /Source="Nicolas_upshifts" /id="D187" /incds=0 /nref=48 /ntot=206 /MaxReadThrough="3.20352" /MaxDrop="4.57855" /score="1.36962171" /energy="-10.6" /TU="U320" /idTUdmin="U318" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" promotor_-35 448584..448591 /Source="Nicolas_upshift_promotors" /id="U321" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.779220779220779" /psig="0.995004995004995" /xcortree=1547 /SigmaFactorBS="gtcacaccgcttagtgccaaattaccatttataagTGATTGA TtctttcttgaaagCGTTTTATATTAAAAGGAAAcctctctatatcctctactgcatc t" /listShort="S138, mtlR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 448605..448624 /Source="Nicolas_upshift_promotors" /id="U321" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.779220779220779" /psig="0.995004995004995" /xcortree=1547 /SigmaFactorBS="gtcacaccgcttagtgccaaattaccatttataagTGATTGA TtctttcttgaaagCGTTTTATATTAAAAGGAAAcctctctatatcctctactgcatc t" /listShort="S138, mtlR" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 448609..448696 /Source="Nicolas_S_feature" /locus_tag="new_467042_467129" /HighExp="S0, Gly, BC, Lbstat, S2, M9-stat, G135, dia5, T0.30H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.995, 0.946" /TUlongSig="NA" /TUlongPSig="NA" /label="S138" upshifts 448609 /Source="Nicolas_upshifts" /id="U321" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.779220779220779" /psig="0.995004995004995" /xcortree=1547 /SigmaFactorBS="gtcacaccgcttagtgccaaattaccatttataagTGATTGA TtctttcttgaaagCGTTTTATATTAAAAGGAAAcctctctatatcctctactgcatc t" /listShort="S138, mtlR" /GFF_Attribute="listLong" /label="upshifts" CDS 448697..450781 /gene="mtlR" /locus_tag="BSU_04160" /old_locus_tag="BSU04160" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12897001, 23279188, 24196428, 26159071" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12897001, 23279188, 24196428, 26159071; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator, PTS-dependent activator" /protein_id="NP_388297.1" /db_xref="EnsemblGenomes-Gn:BSU04160" /db_xref="EnsemblGenomes-Tr:CAB12223" /db_xref="GOA:P96574" /db_xref="InterPro:IPR002178" /db_xref="InterPro:IPR003501" /db_xref="InterPro:IPR007737" /db_xref="InterPro:IPR011608" /db_xref="InterPro:IPR013011" /db_xref="InterPro:IPR013196" /db_xref="InterPro:IPR016152" /db_xref="InterPro:IPR036095" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="InterPro:IPR036634" /db_xref="SubtiList:BG12049" /db_xref="UniProtKB/Swiss-Prot:P96574" /translation="MYMTAREQKLLKHLLLQNRYITVTELAELMQVSTRTIHRELKSI KPLMETVGLTLDKQPGKGLKAVGSPEGKQKLLTDLSYEQHEYSADERKLLILCSLLES QEPVKLYTLAHDLQVTNATVSYDLDELEKWISPFGLTLIRKRGFGIQLIGPENAKRKI VGNLIVNRLDIQMFLEAVELNIKGKTDSSEKMFGVVSKGELLKMERILFQLKEKIAFS LSDSSYIALVVHLTYAIERIKLGETITMEQNELEELMNAKEYSSALEIAGELERAFGV TIPEAEVGYITIHLRSANRKYKTEYKAQEIELETALQTKRLIAFISDKIRMDLTKNYS LYEGLIAHLEPAVSRIKENIEIYNPMKEQIKRDYFLLYMAIEEGVEKYFPGMSFSDDE IAFIVLHFGSALEIKKEEAKVKALVVCSSGIGSSKMLASRLKKELPEIESFDMSSLIE LKGKDVQAYDMIVSTVPIPYENIDYIMVSPLLNEEDANQVKQYIKRKIPLILNKKRSS KEEAQQADVPDMLEAAESIGRYMEVIQDVLRHFTLAQLKTNPDHSMLLLELFQQLKKD GLIRDPEKAAVCLAEREKQGGLGIPGTNMALYHLKNDEIVLPFFKMFDLSTPYEVDGM DGNTLRMTRILVMMAPGSLSAEGSEILSAISSAIIESGESMAGFQEEGGQELYQRLNR IFFTWMKEKNIL*" /label="mtlR CDS" gene 448697..450781 /gene="mtlR" /locus_tag="BSU_04160" /old_locus_tag="BSU04160" /label="mtlR gene" downshifts 450768 /Source="Nicolas_upshifts" /id="D188" /incds=0 /nref=107 /ntot=220 /MaxReadThrough="1.91059" /MaxDrop="5.63565" /score="9.4904968" /energy="-12.4" /TU="NA" /idTUdmin="U321" /TUdmin="-19" /isTUend="TRUE" /label="downshifts" promotor_-35 450810..450816 /Source="Nicolas_upshift_promotors" /id="U322" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=739 /SigmaFactorBS="acctgcatggcacacgtcaaaaatttggCGTGTGTttttctg tggatgGGGAACAAAATAAGAAAATgtgggactattttatcattcagtattggaataa t" /listShort="S139, ydaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 450830..450848 /Source="Nicolas_upshift_promotors" /id="U322" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=739 /SigmaFactorBS="acctgcatggcacacgtcaaaaatttggCGTGTGTttttctg tggatgGGGAACAAAATAAGAAAATgtgggactattttatcattcagtattggaataa t" /listShort="S139, ydaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 450842 /Source="Nicolas_upshifts" /id="U322" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=739 /SigmaFactorBS="acctgcatggcacacgtcaaaaatttggCGTGTGTttttctg tggatgGGGAACAAAATAAGAAAATgtgggactattttatcattcagtattggaataa t" /listShort="S139, ydaB" /GFF_Attribute="listLong" /label="upshifts" S_feature 450853..450934 /Source="Nicolas_S_feature" /locus_tag="new_469286_469367" /HighExp="Etha, S5, S6, ferm, S8, nit, S7, BT, Salt, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S139" promotor_-35 450896..450903 /Source="Nicolas_upshift_promotors" /id="U323" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.69030969030969" /psig="0.992007992007992" /xcortree=1439 /SigmaFactorBS="gaataattccaaaatgaaatAGTTTTACaagttatctttttT GGGTTAAAATGGGTGAGGTaaggaagaaaatctaacaaattattgaagattcaagaga a" /listShort="ydaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 450917..450936 /Source="Nicolas_upshift_promotors" /id="U323" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.69030969030969" /psig="0.992007992007992" /xcortree=1439 /SigmaFactorBS="gaataattccaaaatgaaatAGTTTTACaagttatctttttT GGGTTAAAATGGGTGAGGTaaggaagaaaatctaacaaattattgaagattcaagaga a" /listShort="ydaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 450936 /Source="Nicolas_upshifts" /id="U323" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.69030969030969" /psig="0.992007992007992" /xcortree=1439 /SigmaFactorBS="gaataattccaaaatgaaatAGTTTTACaagttatctttttT GGGTTAAAATGGGTGAGGTaaggaagaaaatctaacaaattattgaagattcaagaga a" /listShort="ydaB" /GFF_Attribute="listLong" /label="upshifts" CDS 450993..452504 /gene="ydaB" /locus_tag="BSU_04170" /old_locus_tag="BSU04170" /EC_number="6.2.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyl-CoA ligase" /protein_id="NP_388298.2" /db_xref="EnsemblGenomes-Gn:BSU04170" /db_xref="EnsemblGenomes-Tr:CAB12224" /db_xref="GOA:P96575" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="SubtiList:BG12050" /db_xref="UniProtKB/Swiss-Prot:P96575" /translation="METLQHLILHDMPNSEEIEAVKSGDHTLTYKGYRKRINQLANAM LQKGIQKGDRVALLCKNGHPASTVMFAALEIGAVVVPVSWQLKPYEMTGILKASEPKA MFYGAEFKEILDEVLPELSSLCVTMETGTAYETSAEFEALFAGPDHLPETEMVSPDDT ALLMFTSGTTGNPKRCMITHGGIYRYVKKSNSSIARMKGLRFLACHPIYHTSALICIM LGTFAETTFVFTKDQDPVHMLKVIEEEKIQTVMALPVFYTYLLEAWEKHQTDLSSLVI LMTGGTKVPSSLISRYLDIGIPLAHGYGSTEAWGISTWTPDMGMDKAASAGKPVAGVK VKVEDPLTGEELPQGEIGEIVVHTPFLFKGYEDNPEATAKVLQNGWFRTGDSGYVDED GFIFITGRYKDVIIYGGDNVYPDQVEEVIQQIPGILETAVVGIPDPLYGEKPKAFIVK NGGQRITEEDVIAFCKERLSAYKIPEVEFVNELPKNNLGKVKKDVLRNQAVHS*" /label="ydaB CDS" gene 450993..452504 /gene="ydaB" /locus_tag="BSU_04170" /old_locus_tag="BSU04170" /label="ydaB gene" downshifts 452488 /Source="Nicolas_upshifts" /id="D189" /incds=0 /nref=3 /ntot=55 /MaxReadThrough="0.57376" /MaxDrop="3.70168" /score="9.4904968" /energy="-12.4" /TU="NA" /idTUdmin="U323" /TUdmin=73 /isTUend="FALSE" /label="downshifts" CDS complement(452524..453069) /gene="ydaC" /locus_tag="BSU_04180" /old_locus_tag="BSU04180" /EC_number="2.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative methyltransferase" /protein_id="NP_388299.1" /db_xref="EnsemblGenomes-Gn:BSU04180" /db_xref="EnsemblGenomes-Tr:CAB12225" /db_xref="GOA:P96576" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG12051" /db_xref="UniProtKB/Swiss-Prot:P96576" /translation="MIAGYIMAAENQTLNQWTINQLGITRGDSILEVGFGPGYCMQQM LKREKDVHLHGIDVSEAMLKLAARRVKPKGVRLIQGSIETFPLPASFYDKVISVNNYT IWNDQTKGIKQIYRALKPGGKAAITMQPREADASPEKTKSFGRQMIADFKAAGFEDID IQFKNIKPELSVCATAKKPAT*" /label="ydaC CDS" gene complement(452524..453069) /gene="ydaC" /locus_tag="BSU_04180" /old_locus_tag="BSU04180" /label="ydaC gene" downshifts complement(452557) /Source="Nicolas_upshifts" /id="D190" /incds=0 /nref=3 /ntot=11 /MaxReadThrough="1.44039" /MaxDrop="3.73662" /score="-9.35066962" /energy="-11.5" /TU="NA" /idTUdmin="U324" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(453136..453154) /Source="Nicolas_upshift_promotors" /id="U324" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=211 /SigmaFactorBS="tggcttggcaccttcgcattgctttatcagaaaaaTGTTTCA catggaacgctgagAGGAAATTAACTCAAAAAGggggttggttgctgaatgattaaca t" /listShort="ydaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(453150) /Source="Nicolas_upshifts" /id="U324" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=211 /SigmaFactorBS="tggcttggcaccttcgcattgctttatcagaaaaaTGTTTCA catggaacgctgagAGGAAATTAACTCAAAAAGggggttggttgctgaatgattaaca t" /listShort="ydaC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(453169..453175) /Source="Nicolas_upshift_promotors" /id="U324" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=211 /SigmaFactorBS="tggcttggcaccttcgcattgctttatcagaaaaaTGTTTCA catggaacgctgagAGGAAATTAACTCAAAAAGggggttggttgctgaatgattaaca t" /listShort="ydaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 453211..453217 /Source="Nicolas_upshift_promotors" /id="U325" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=191 /SigmaFactorBS="tgaaacatttttctgataaagcaatgcgaaggtgccaagcca TGTTTATccaaagagtgtgtgAGGTACACAACAAATAGACatgaaaacaaaggaggag a" /listShort="ydaD, ydaE, ydaF" /listLong="ydaG, S140" /label="promotor_-35" upshifts 453229 /Source="Nicolas_upshifts" /id="U325" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=191 /SigmaFactorBS="tgaaacatttttctgataaagcaatgcgaaggtgccaagcca TGTTTATccaaagagtgtgtgAGGTACACAACAAATAGACatgaaaacaaaggaggag a" /listShort="ydaD, ydaE, ydaF" /listLong="ydaG, S140" /label="upshifts" promotor_-10 453232..453250 /Source="Nicolas_upshift_promotors" /id="U325" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=191 /SigmaFactorBS="tgaaacatttttctgataaagcaatgcgaaggtgccaagcca TGTTTATccaaagagtgtgtgAGGTACACAACAAATAGACatgaaaacaaaggaggag a" /listShort="ydaD, ydaE, ydaF" /listLong="ydaG, S140" /label="promotor_-10" CDS 453276..454136 /gene="ydaD" /locus_tag="BSU_04190" /old_locus_tag="BSU04190" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10220166, 11948145, 15805528, 21520290, 28197687; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dehydrogenase" /protein_id="NP_388300.1" /db_xref="EnsemblGenomes-Gn:BSU04190" /db_xref="EnsemblGenomes-Tr:CAB12226" /db_xref="GOA:P80873" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12052" /db_xref="UniProtKB/Swiss-Prot:P80873" /translation="MANYPKELPAQTQSRQPGIESEMNPSPVYEYEDYKGADKLKGKV ALITGGDSGIGRAVSVAYAKEGADIAIVYKDEHEDAEETKKRVEQEGVKCLLIAGDVG EEEFCNEAVEKTVKELGGLDILVNNAGEQHPKESIKDITSEQLHRTFKTNFYSQFYLT KKAIDYLKPGSAIINTTSINPYVGNPTLIDYTATKGAINAFTRTMAQALVKDGIRVNA VAPGPIWTPLIPATFPEETVAQFGQDTPMGRPGQPVEHVGCYVLLASDESSYMTGQTL HVNGGNFVTT*" /label="ydaD CDS" gene 453276..454136 /gene="ydaD" /locus_tag="BSU_04190" /old_locus_tag="BSU04190" /label="ydaD gene" CDS 454152..454655 /gene="lyxE" /locus_tag="BSU_04200" /old_locus_tag="BSU04200" /EC_number="5.3.1.15" /experiment="publication(s) with functional evidences, PMID:10220166, 15805528, 21421786, 21520290" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10220166, 15805528, 21421786, 21520290; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-lyxose ketol isomerase" /protein_id="NP_388301.1" /db_xref="EnsemblGenomes-Gn:BSU04200" /db_xref="EnsemblGenomes-Tr:CAB12227" /db_xref="GOA:P96578" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014710" /db_xref="PDB:2Y0O" /db_xref="SubtiList:BG12053" /db_xref="UniProtKB/Swiss-Prot:P96578" /translation="MGITKEEVNSYYQKAGIVLTDEEVDQIQLMDYGLGKERKVGLQL FVYVNTDRYCSKELVLFPGQTCPEHRHPPVDGQEGKQETFRCRYGKVYLYVEGEKTPL PKVLPPQEDREHYTVWHEIELEPGGQYTIPPNTKHWFQAGEEGAVVTEMSSTSTDKHD IFTDPRI*" /label="lyxE CDS" gene 454152..454655 /gene="lyxE" /locus_tag="BSU_04200" /old_locus_tag="BSU04200" /label="lyxE gene" downshifts 454636 /Source="Nicolas_upshifts" /id="D191" /incds=0 /nref=16 /ntot=26 /MaxReadThrough="4.81615" /MaxDrop="6.21035" /score="29.8440619" /energy="-15.5" /TU="U325" /idTUdmin="U325" /TUdmin="-683" /isTUend="FALSE" /label="downshifts" promotor_-35 454684..454691 /Source="Nicolas_upshift_promotors" /id="U326" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2929 /SigmaFactorBS="agaatataaggatgggcttaacagcccatcctttttgTATTG AAAaaaacagaatcatCGCTATAATGGGTAAAAAAGgaaagagggcgaggcaatgttc a" /listShort="ydaF, ydaG, S140" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 454705..454724 /Source="Nicolas_upshift_promotors" /id="U326" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2929 /SigmaFactorBS="agaatataaggatgggcttaacagcccatcctttttgTATTG AAAaaaacagaatcatCGCTATAATGGGTAAAAAAGgaaagagggcgaggcaatgttc a" /listShort="ydaF, ydaG, S140" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 454707 /Source="Nicolas_upshifts" /id="U326" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2929 /SigmaFactorBS="agaatataaggatgggcttaacagcccatcctttttgTATTG AAAaaaacagaatcatCGCTATAATGGGTAAAAAAGgaaagagggcgaggcaatgttc a" /listShort="ydaF, ydaG, S140" /GFF_Attribute="listLong" /label="upshifts" CDS 454741..455292 /gene="ydaF" /locus_tag="BSU_04210" /old_locus_tag="BSU04210" /EC_number="2.3.1.-" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15468321; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ribosomal protein N-acetyltransferase" /protein_id="NP_388302.1" /db_xref="EnsemblGenomes-Gn:BSU04210" /db_xref="EnsemblGenomes-Tr:CAB12228" /db_xref="GOA:P96579" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="PDB:1NSL" /db_xref="SubtiList:BG12054" /db_xref="UniProtKB/Swiss-Prot:P96579" /translation="MFTCKVNEHITIRLLEPKDAERLAELIIQNQQRLGKWLFFAENP SSADTYRETIIPDWRRQYADLNGIEAGLLYDGSLCGMISLHNLDQVNRKAEIGYWIAK EFEGKGIITAACRKLITYAFEELELNRVAICAAVGNEKSRAVPERIGFLEEGKARDGL YVNGMHHDLVYYSLLKREWEGEK*" /label="ydaF CDS" gene 454741..455292 /gene="ydaF" /locus_tag="BSU_04210" /old_locus_tag="BSU04210" /label="ydaF gene" promotor_-35 455307..455313 /Source="Nicolas_upshift_promotors" /id="U327" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=268 /SigmaFactorBS="ggcgaaaaataaagagcacactttctTGTTTAAatcttcccc ggatgTGGAAAAGTAACAGCGGAGacgttaaaaaggagtgattcgagatgaatcagca a" /listShort="ydaG, S140" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 455328..455346 /Source="Nicolas_upshift_promotors" /id="U327" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=268 /SigmaFactorBS="ggcgaaaaataaagagcacactttctTGTTTAAatcttcccc ggatgTGGAAAAGTAACAGCGGAGacgttaaaaaggagtgattcgagatgaatcagca a" /listShort="ydaG, S140" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 455341 /Source="Nicolas_upshifts" /id="U327" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=268 /SigmaFactorBS="ggcgaaaaataaagagcacactttctTGTTTAAatcttcccc ggatgTGGAAAAGTAACAGCGGAGacgttaaaaaggagtgattcgagatgaatcagca a" /listShort="ydaG, S140" /GFF_Attribute="listLong" /label="upshifts" CDS 455370..455792 /gene="ydaG" /locus_tag="BSU_04220" /old_locus_tag="BSU04220" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10220166; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative general stress protein" /protein_id="NP_388303.1" /db_xref="EnsemblGenomes-Gn:BSU04220" /db_xref="EnsemblGenomes-Tr:CAB12229" /db_xref="GOA:P80238" /db_xref="InterPro:IPR012349" /db_xref="SubtiList:BG19017" /db_xref="UniProtKB/Swiss-Prot:P80238" /translation="MNQQDIKQKVLDVLDHHKVGSLATVQKGKPHSRYMTFFHDGLTI YTPTSKETHKAEEIENNPNVHILLGYDCEGFGDAYVEVAGKAKINNSAELKDKIWSSK LERWFDGKDDPNLVILEIEPEDIRLMNAGEKTPVSLEL*" /label="ydaG CDS" gene 455370..455792 /gene="ydaG" /locus_tag="BSU_04220" /old_locus_tag="BSU04220" /label="ydaG gene" promotor_-35 455797..455805 /Source="Nicolas_upshift_promotors" /id="U328" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.753246753246753" /psig="0.993006993006993" /xcortree=273 /SigmaFactorBS="gtctcactcgaactataaaaaaTTTGTGTTTtcaggggcgaT ATGTTATTATGAATAGCTAgtaagaaaaataagcaaataaaaaagaaagtaaacttct t" /listShort="S140" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 455816..455835 /Source="Nicolas_upshift_promotors" /id="U328" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.753246753246753" /psig="0.993006993006993" /xcortree=273 /SigmaFactorBS="gtctcactcgaactataaaaaaTTTGTGTTTtcaggggcgaT ATGTTATTATGAATAGCTAgtaagaaaaataagcaaataaaaaagaaagtaaacttct t" /listShort="S140" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 455835..456201 /Source="Nicolas_S_feature" /locus_tag="new_474268_474634" /HighExp="Etha, Salt, Cold, Sw, B60, Gly, M9-stat, LPhT, B36, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB, SigA" /TUshortPSig="0.993, 0.999, 1" /TUlongSig="SigB" /TUlongPSig=1 /label="S140" upshifts 455835 /Source="Nicolas_upshifts" /id="U328" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.753246753246753" /psig="0.993006993006993" /xcortree=273 /SigmaFactorBS="gtctcactcgaactataaaaaaTTTGTGTTTtcaggggcgaT ATGTTATTATGAATAGCTAgtaagaaaaataagcaaataaaaaagaaagtaaacttct t" /listShort="S140" /GFF_Attribute="listLong" /label="upshifts" promotor_no_box complement(455861..455961) /Source="Nicolas_upshift_promotors" /id="U329" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.725274725274725" /psig="0.010989010989011" /xcortree=121 /SigmaFactorBS="aggggcgatttgttatgaaggaaaagaataagggcagctggt tatgctgcttgggaagcggtaagcttctctctcaaaacagaaaaaagaagtttacttt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" misc_RNA complement(455896..456164) /gene="bsrC" /locus_tag="BSU_misc_RNA_64" /product="small regulatory RNA" /experiment="publication(s) with functional evidences, PMID:18948176, 23457461" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18948176, 23457461; Product type n: RNA" /label="bsrC RNA" gene complement(455896..456164) /gene="bsrC" /locus_tag="BSU_misc_RNA_64" /label="bsrC gene" upshifts complement(455901) /Source="Nicolas_upshifts" /id="U329" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.725274725274725" /psig="0.010989010989011" /xcortree=121 /SigmaFactorBS="aggggcgatttgttatgaaggaaaagaataagggcagctggt tatgctgcttgggaagcggtaagcttctctctcaaaacagaaaaaagaagtttacttt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 456158 /Source="Nicolas_upshifts" /id="D192" /incds=0 /nref=124 /ntot=275 /MaxReadThrough="2.67264" /MaxDrop="7.35087" /score="29.9942993" /energy="-12" /TU="NA" /idTUdmin="U326" /TUdmin=3 /isTUend="TRUE" /label="downshifts" promotor_-35 456238..456247 /Source="Nicolas_upshift_promotors" /id="U330" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1651 /SigmaFactorBS="gacggtttttttattgcaaaaaacacatcgtacTGAAACCTC CttgtcttctttcCAGTCTTATCTCTAGGatgaaattggaggaagaataacgtgcatg t" /listShort="ydaH, lrpC, topB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 456260..456275 /Source="Nicolas_upshift_promotors" /id="U330" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1651 /SigmaFactorBS="gacggtttttttattgcaaaaaacacatcgtacTGAAACCTC CttgtcttctttcCAGTCTTATCTCTAGGatgaaattggaggaagaataacgtgcatg t" /listShort="ydaH, lrpC, topB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 456265 /Source="Nicolas_upshifts" /id="U330" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1651 /SigmaFactorBS="gacggtttttttattgcaaaaaacacatcgtacTGAAACCTC CttgtcttctttcCAGTCTTATCTCTAGGatgaaattggaggaagaataacgtgcatg t" /listShort="ydaH, lrpC, topB" /GFF_Attribute="listLong" /label="upshifts" CDS 456298..457107 /gene="amj" /locus_tag="BSU_04230" /old_locus_tag="BSU04230" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 25918422, 27537185" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 25918422, 27537185; Product type t: transporter" /codon_start=1 /transl_table=11 /product="lipid II flippase" /protein_id="NP_388304.1" /db_xref="EnsemblGenomes-Gn:BSU04230" /db_xref="EnsemblGenomes-Tr:CAB12230" /db_xref="GOA:P96581" /db_xref="InterPro:IPR021260" /db_xref="SubtiList:BG12055" /db_xref="UniProtKB/Swiss-Prot:P96581" /translation="MHVITTQVLFIFCFLLLIHSIETLAYATRLSGARVGFIASALSL FNVMVIVSRMSNMVQQPFTGHLIDDAGKNALAIVGEQFRFLIFGSTVGTILGIILLPS FVALFSRAIIHLAGGGGSVFQVFRKGFSKQGFKNALSYLRLPSISYVKGFHMRLIPKR LFVINMLITSIYTIGVLSALYAGLLAPERSTTAVMASGLINGIATMLLAIFVDPKVSV LADDVAKGKRSYIYLKWTSVTMVTSRVAGTLLAQLMFIPGAYYIAWLTKWF*" /label="amj CDS" gene 456298..457107 /gene="amj" /locus_tag="BSU_04230" /old_locus_tag="BSU04230" /label="amj gene" downshifts 457088 /Source="Nicolas_upshifts" /id="D193" /incds=0 /nref=5 /ntot=103 /MaxReadThrough="2.92236" /MaxDrop="3.54247" /score="15.7032536" /energy="-14.9" /TU="U330" /idTUdmin="U327" /TUdmin=911 /isTUend="FALSE" /label="downshifts" CDS complement(457151..457441) /gene="ydzA" /locus_tag="BSU_04240" /old_locus_tag="BSU04240" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388305.1" /db_xref="EnsemblGenomes-Gn:BSU04240" /db_xref="EnsemblGenomes-Tr:CAB12231" /db_xref="GOA:O31485" /db_xref="InterPro:IPR023845" /db_xref="SubtiList:BG12807" /db_xref="UniProtKB/Swiss-Prot:O31485" /translation="MLHTPIGRLRTMGFIEGMSLLILLFIAMPLKYWAGLPLAVTIVG SVHGGLFILYLLVLAYATFSVKWPLKWSAAGFIAAFVPFGNFLYDRGLRNYK*" /label="ydzA CDS" gene complement(457151..457441) /gene="ydzA" /locus_tag="BSU_04240" /old_locus_tag="BSU04240" /label="ydzA gene" downshifts complement(457155) /Source="Nicolas_upshifts" /id="D194" /incds=0 /nref=235 /ntot=260 /MaxReadThrough="1.23465" /MaxDrop="7.74945" /score="10.1798531" /energy="-14.9" /TU="NA" /idTUdmin="U332" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(457469..457488) /Source="Nicolas_upshift_promotors" /id="U332" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.653346653346653" /psig="0.967032967032967" /xcortree=1622 /SigmaFactorBS="catgtaaaaatgaatgttttccgaacattttttgaaagctgt catatgcccccccggATTGTTTATAGTATAAAATGaaaacgtgtccacaaggagggcg a" /listShort="ydzA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" misc_feature 457469..457487 /Source="Nicolas_upshift_promotors" /id="U331" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.343656343656344" /psig="0.691308691308691" /xcortree=306 /SigmaFactorBS="aagtcttccgatcggcgtgtgcagcataaatcgccctccttg tggacacgttttCATTTTATACTATAAACAAtccgggggggcatatgacagctttcaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 457475 /Source="Nicolas_upshifts" /id="U331" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.343656343656344" /psig="0.691308691308691" /xcortree=306 /SigmaFactorBS="aagtcttccgatcggcgtgtgcagcataaatcgccctccttg tggacacgttttCATTTTATACTATAAACAAtccgggggggcatatgacagctttcaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(457485) /Source="Nicolas_upshifts" /id="U332" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.653346653346653" /psig="0.967032967032967" /xcortree=1622 /SigmaFactorBS="catgtaaaaatgaatgttttccgaacattttttgaaagctgt catatgcccccccggATTGTTTATAGTATAAAATGaaaacgtgtccacaaggagggcg a" /listShort="ydzA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 457563..457570 /Source="Nicolas_upshift_promotors" /id="U333" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.765234765234765" /psig="0.999000999001" /xcortree=2269 /SigmaFactorBS="aacattcatttttacatgccttttctagggaactgTACTTGT CatttacaaaaataCCCGAGATAATGTGTACAAAatcaaaaaagaaggatgttgaaat g" /listShort="lrpC, topB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 457584..457603 /Source="Nicolas_upshift_promotors" /id="U333" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.765234765234765" /psig="0.999000999001" /xcortree=2269 /SigmaFactorBS="aacattcatttttacatgccttttctagggaactgTACTTGT CatttacaaaaataCCCGAGATAATGTGTACAAAatcaaaaaagaaggatgttgaaat g" /listShort="lrpC, topB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 457588 /Source="Nicolas_upshifts" /id="U333" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.765234765234765" /psig="0.999000999001" /xcortree=2269 /SigmaFactorBS="aacattcatttttacatgccttttctagggaactgTACTTGT CatttacaaaaataCCCGAGATAATGTGTACAAAatcaaaaaagaaggatgttgaaat g" /listShort="lrpC, topB" /GFF_Attribute="listLong" /label="upshifts" CDS 457626..458060 /gene="lrpC" /locus_tag="BSU_04250" /old_locus_tag="BSU04250" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9341680, 10606655, 10913073, 12458218, 16407330, 16528101" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9341680, 10606655, 10913073, 12458218, 16407330, 16528101; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (Lrp/AsnC family)" /protein_id="NP_388306.1" /db_xref="EnsemblGenomes-Gn:BSU04250" /db_xref="EnsemblGenomes-Tr:CAB12232" /db_xref="GOA:P96582" /db_xref="InterPro:IPR000485" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR019887" /db_xref="InterPro:IPR019888" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2CFX" /db_xref="SubtiList:BG12056" /db_xref="UniProtKB/Swiss-Prot:P96582" /translation="MKLDQIDLNIIEELKKDSRLSMRELGRKIKLSPPSVTERVRQLE SFGIIKQYTLEVDQKKLGLPVSCIVEATVKNADYERFKSYIQTLPNIEFCYRIAGAAC YMLKINAESLEAVEDFINKTSPYAQTVTHVIFSEIDTKNGRG*" /label="lrpC CDS" gene 457626..458060 /gene="lrpC" /locus_tag="BSU_04250" /old_locus_tag="BSU04250" /label="lrpC gene" promotor_-35 458057..458060 /Source="Nicolas_upshift_promotors" /id="U334" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.685314685314685" /psig="0.988011988011988" /xcortree=2491 /SigmaFactorBS="cgtcactcacgtcattttctcagaaattgacacgaaaaacgg gcgcggTTAGagagtgccgcgcgaagTCTGTTATAATAACAGGATGagcgtgaaagaa a" /listShort="topB, S141, ydaJ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 458069 /Source="Nicolas_upshifts" /id="U334" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.685314685314685" /psig="0.988011988011988" /xcortree=2491 /SigmaFactorBS="cgtcactcacgtcattttctcagaaattgacacgaaaaacgg gcgcggTTAGagagtgccgcgcgaagTCTGTTATAATAACAGGATGagcgtgaaagaa a" /listShort="topB, S141, ydaJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 458077..458096 /Source="Nicolas_upshift_promotors" /id="U334" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.685314685314685" /psig="0.988011988011988" /xcortree=2491 /SigmaFactorBS="cgtcactcacgtcattttctcagaaattgacacgaaaaacgg gcgcggTTAGagagtgccgcgcgaagTCTGTTATAATAACAGGATGagcgtgaaagaa a" /listShort="topB, S141, ydaJ" /GFF_Attribute="listLong" /label="promotor_-10" CDS 458125..460308 /gene="topB" /locus_tag="BSU_04260" /old_locus_tag="BSU04260" /EC_number="5.99.1.2" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 16192570, 16556226; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA topoisomerase III" /protein_id="NP_388307.1" /db_xref="EnsemblGenomes-Gn:BSU04260" /db_xref="EnsemblGenomes-Tr:CAB12233" /db_xref="GOA:P96583" /db_xref="InterPro:IPR000380" /db_xref="InterPro:IPR003601" /db_xref="InterPro:IPR003602" /db_xref="InterPro:IPR005738" /db_xref="InterPro:IPR006171" /db_xref="InterPro:IPR013497" /db_xref="InterPro:IPR013825" /db_xref="InterPro:IPR023405" /db_xref="InterPro:IPR023406" /db_xref="InterPro:IPR034144" /db_xref="SubtiList:BG11979" /db_xref="UniProtKB/Swiss-Prot:P96583" /translation="MSKTVVLAEKPSVGRDLARVLKCHKKGNGYLEGDQYIVTWALGH LVTLADPEGYGKEFQSWRLEDLPIIPEPLKLVVIKKTGKQFNAVKSQLTRKDVNQIVI ATDAGREGELVARWIIEKANVRKPIKRLWISSVTDKAIKEGFQKLRSGKEYENLYHSA VARAEADWIVGINATRALTTKFNAQLSCGRVQTPTLAMIAKREADIQAFTPVPYYGIR AAVDGMTLTWQDKKSKQTRTFNQDVTSRLLKNLQGKQAVVAELKKTAKKSFAPALYDL TELQRDAHKRFGFSAKETLSVLQKLYEQHKLVTYPRTDSRFLSSDIVPTLKDRLEGME VKPYAQYVSQIKKRGIKSHKGYVNDAKVSDHHAIIPTEEPLVLSSLSDKERKLYDLIA KRFLAVLMPAFEYEETKVIAEIGGETFTAKGKTVQSQGWKAVYDMAEEDDEQEDDRDQ TLPALQKGDTLAVRTLTETSGQTKPPARFNEGTLLSAMENPSAFMQGEEKGLVKTLGE TGGLGTVATRADIIEKLFNSFLIEKKGQDIFITSKGKQLLQLVPEDLKSPALTAEWEQ KLSAIAAGKLKSAVFIKDMKAYAHQTVKEIKNSSQTFRHDNITGTACPECGKMMLKVN GKRGTMLVCQDRECGSRKTIARKTNARCPNCHKRMELRGQGEGQTFACVCGHREKLSV FEKRKNKDKARATKRDVSSYMKKQNKDEPINNALAEQLKKLGLDK*" /label="topB CDS" gene 458125..460308 /gene="topB" /locus_tag="BSU_04260" /old_locus_tag="BSU04260" /label="topB gene" downshifts 460291 /Source="Nicolas_upshifts" /id="D195" /incds=0 /nref=133 /ntot=245 /MaxReadThrough="3.22367" /MaxDrop="6.18597" /score="23.5229393" /energy="-10.4" /TU="U334" /idTUdmin="U333" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 460357..460363 /Source="Nicolas_upshift_promotors" /id="U335" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=179 /SigmaFactorBS="tgtgcctatcgcacaggttttttattggacttaggtccTGTT TTCttaatgttcaaaaaGGGAAAAAAAAGCTAGCAAtctgcattttttttcttttata g" /listShort="S141, ydaJ, ydaK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 460378..460396 /Source="Nicolas_upshift_promotors" /id="U335" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=179 /SigmaFactorBS="tgtgcctatcgcacaggttttttattggacttaggtccTGTT TTCttaatgttcaaaaaGGGAAAAAAAAGCTAGCAAtctgcattttttttcttttata g" /listShort="S141, ydaJ, ydaK" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 460379..460510 /Source="Nicolas_S_feature" /locus_tag="new_478812_478943" /HighExp="Etha, Salt, Heat, Cold, H2O2, G180, LPhT, Oxctl, Paraq, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigA" /TUshortPSig="1, 0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S141" upshifts 460379 /Source="Nicolas_upshifts" /id="U335" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=179 /SigmaFactorBS="tgtgcctatcgcacaggttttttattggacttaggtccTGTT TTCttaatgttcaaaaaGGGAAAAAAAAGCTAGCAAtctgcattttttttcttttata g" /listShort="S141, ydaJ, ydaK" /GFF_Attribute="listLong" /label="upshifts" CDS 460511..461599 /gene="epsJ" /locus_tag="BSU_04270" /old_locus_tag="BSU04270" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15661000, 26078454, 27897378" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15661000, 26078454, 27897378; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="glycosyl hydrolase lipoprotein" /protein_id="NP_388308.1" /db_xref="EnsemblGenomes-Gn:BSU04270" /db_xref="EnsemblGenomes-Tr:CAB12234" /db_xref="GOA:O31486" /db_xref="InterPro:IPR008928" /db_xref="SubtiList:BG12057" /db_xref="UniProtKB/Swiss-Prot:O31486" /translation="MRHVLIAVILFFLSIGLSAGCAEAGNKTQNQSATEVNASPLQPA EYFIYHNLMNDKGLIKTDFSDQPSYLSESLGLWMEFLLSKNDAPHFQDQYQHLTDSFL MSNHLVTWKIQNGQASGTNALIDDMRIMLSLDQAAAKWGRSDYAQTARDIGTSLKTYN MNNGFFTDFYDSQAASKDVTLSYVMPDALAVLKKNGIIDEETEQRNANVLYSAPLKNG FLPKTYSSETKEYTYDSEINLIDQLYAAWHLPEGDEKASVLADWIKQEFQKNGKLYGR YSAYTKEPAVQYESPSVYALAVLFLTKQHENSSVIKAIYDRMNDFEIHDPVKSYYGGY MSGTQTHSFDNLLPLLAERKLFNENIIQ*" /label="epsJ CDS" gene 460511..461599 /gene="epsJ" /locus_tag="BSU_04270" /old_locus_tag="BSU04270" /label="epsJ gene" CDS 461580..462431 /gene="epsK" /locus_tag="BSU_04280" /old_locus_tag="BSU04280" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:23893111, 27897378" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23893111, 27897378; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="cyclic-di-GMP receptor" /protein_id="NP_388309.1" /db_xref="EnsemblGenomes-Gn:BSU04280" /db_xref="EnsemblGenomes-Tr:CAB12235" /db_xref="GOA:P96585" /db_xref="InterPro:IPR000160" /db_xref="InterPro:IPR029787" /db_xref="SubtiList:BG12058" /db_xref="UniProtKB/Swiss-Prot:P96585" /translation="MKISFSESQKLFAYFSGLIAALSLFIYYVSAQQSEGALILCITF GVIAAGIWFGPIYALAVTLIVLFVLGTLMMFFQTGQTSLFPAEEGLRMLVVWGIALLL FSFISGRIHDITAELRRSMTRLQSEIKSYVAVDRVTGFDNKQRMKLELSEEIKRAERY GNSFVFLLLHMHYFKEFKSLYGEKETDRLFQYVGQQIRTSVRETDKKFRPSDERIGIV LTHTPAEHMPAVLTKLKKQLDTYQLENGKYVSLTFHVCYLPYRNDIQTADQFLEELEN EMMMNEL*" /label="epsK CDS" gene 461580..462431 /gene="epsK" /locus_tag="BSU_04280" /old_locus_tag="BSU04280" /label="epsK gene" CDS 462442..464151 /gene="ydaL" /locus_tag="BSU_04290" /old_locus_tag="BSU04290" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 27897378; Product type ph :phenotype" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388310.1" /db_xref="EnsemblGenomes-Gn:BSU04290" /db_xref="EnsemblGenomes-Tr:CAB12236" /db_xref="GOA:O31487" /db_xref="InterPro:IPR018763" /db_xref="SubtiList:BG12059" /db_xref="UniProtKB/Swiss-Prot:O31487" /translation="MLCVMMLLFSAIASFPVSAQAKDQDAGILIIYSTLDGKESSQVK MLDLLAGHFTSHVTVKKDSDVEASDFKGKDHVIYYGQTKRKLSQKLLSLISGVKKPVV AIGYNAGQISQFSGLSLARKENVFQVHSRSEKADVSLESGLNVLSVSGLKGTALYTFK ADEGTTHSFIWKTKKGNVYIGLTNLLNDNLIVAKQLREAFGEKAGTTLLYLRLEDISP MSDEKLLLQAGTYLHKRHIPFILAVIPVYLNPETGDKVYLSNQPKMVKVLKKLQSMGG SIIVHGYTHAYRYSETGEGFEFWDAKADQPITSGNAEDPPSILEKEQDFPNEQAYHSY LEPFREKEETYTKQKLTRAIEDLTSSGLYPLAFEAPHYTMSEYGYQIASQYFTSIFGQ VQLSSTTWKTSGAPPFVTAPSMLHGMTLYPETIGFVDTSKQNPLGEMEEHISQMIDFE GGVAGGFYHPYLGMKYLPELVDQMERIPDSEWLDLKKTKQTVKTDKVEIHTSGDGTIQ VKNGVSPIYEFFDHHRQTPLEKALWILSAVVLLFVIMFVSYTFYLRATLKKRIFKERR SLG*" /label="ydaL CDS" gene 462442..464151 /gene="ydaL" /locus_tag="BSU_04290" /old_locus_tag="BSU04290" /label="ydaL gene" CDS 464144..465406 /gene="ydaM" /locus_tag="BSU_04300" /old_locus_tag="BSU04300" /EC_number="2.4.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 27897378, 28296273; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase associated to biofilm formation" /protein_id="NP_388311.1" /db_xref="EnsemblGenomes-Gn:BSU04300" /db_xref="EnsemblGenomes-Tr:CAB12237" /db_xref="GOA:P96587" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG12060" /db_xref="UniProtKB/Swiss-Prot:P96587" /translation="MGNTLFFISLSLIWVMLLYHMFLMQGGFRHYMTFERNIPKWREN MKELPKVSVLIPAHNEEVVIRQTLKAMVNLYYPKDRLEIIVVNDNSSDRTGDIVNEFS EKYDFIKMVITKPPNAGKGKSSALNSGFAESNGDVICVYDADNTPEKMAVYYLVLGLM NDEKAGAVVGKFRVINAAKTLLTRFINIETICFQWMAQGGRWKWFKIATIPGTNFAIR RSIIEKLGGWDDKALAEDTELTIRVYNLGYHIRFFPAAITWEQEPETWKVWWRQRTRW ARGNQYVVLKFLAQFFKLKRKRIIFDLFYFFFTYFLFFFGVIMSNAIFVVNLFYDLHL SVGFLAMILWILAFFLFMTEVMITLSIEKTEMNKQNFFIVFLMYFTYSQAWIVLVIYS LFVEIKHRLFKQEVKWYKTERYNQHKSG*" /label="ydaM CDS" gene 464144..465406 /gene="ydaM" /locus_tag="BSU_04300" /old_locus_tag="BSU04300" /label="ydaM gene" CDS 465412..467523 /gene="ydaN" /locus_tag="BSU_04310" /old_locus_tag="BSU04310" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 27897378; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative regulator of exopolysaccharide synthesis" /protein_id="NP_388312.1" /db_xref="EnsemblGenomes-Gn:BSU04310" /db_xref="EnsemblGenomes-Tr:CAB12238" /db_xref="GOA:O31488" /db_xref="InterPro:IPR008979" /db_xref="InterPro:IPR018513" /db_xref="SubtiList:BG12061" /db_xref="UniProtKB/Swiss-Prot:O31488" /translation="MKQIMIFLTSFMLLAMTGQTALAKDVQVSGSLLGKSSQEQAKQQ VLTSELITLYGSKDSAELTYQIPAGASSGNQQLVIEYEASNLLISPSSLTVVIDDEPV KTLKLDGDSKRKTVKLNLNKSQSAQGYHNVSLKFYGVMKEGVCVRQDTSGNWIKIYPD SRLTLADSSEAKGTSLDHYPYPFAQSGNTAEETAIVIPDNPSSAEIEAAVKTEGYLKT VDSSVSIAYVTESELKKIDKPTIVIGVDKHWNGKVKKLLKQAGLQAKGENLLLAERVL KAEGKQQPVLFAQAASEDALTKKISVMTDQTYTGQLSGDTLSISKLQQTEKKESDKLT LENFGAGDITIGADKTSSAHYFYPASAVLDENQSAKLSLKLKKSETIQASTAENESAS QAAELKVMINGQPHSVRLDELGKEDKNGFYHVTVKVDPKLLQKNRYIDIQFVTTGLKE NNPCNTTDEEKWVFIDKNSTLSYAIKGMSPSADFQEWPLPYAGNQDQTTLIVLPDTVS QSKLEELSLVTESFGNEAQHSYTVKKSSDVTANDAKGRNLIFIGGINQFSLLKEKSSD LLVPQEKNGSFDVSSFEMLNETTKQVVFTQASVWDSRYTMAVFAPSKGDGTAVTKEII SYLNSNDESATVLNETNSQQVFTNHQQLKSETNSSDAEQPTQDHSQKWMYIGVLALIM VVAAVFIWIAVRRKKRKTDTE*" /label="ydaN CDS" gene 465412..467523 /gene="ydaN" /locus_tag="BSU_04310" /old_locus_tag="BSU04310" /label="ydaN gene" downshifts 467507 /Source="Nicolas_upshifts" /id="D196" /incds=0 /nref=18 /ntot=91 /MaxReadThrough="0.438479999999999" /MaxDrop="4.36576" /score="34.1370207" /energy="-9.9" /TU="NA" /idTUdmin="U336" /TUdmin="-4598" /isTUend="FALSE" /label="downshifts" promotor_-35 467620..467627 /Source="Nicolas_upshift_promotors" /id="U336" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.976023976023976" /psig="0.998001998001998" /xcortree=2720 /SigmaFactorBS="cattttatttttttctctcagccaataagccTCTTTACAacg tgcgggaacggGAGTATGATCTCTTTTAGAAaacaaatcgcttaatctgaaatcagag c" /listShort="NA, S142, ydaO, mutT, ydaP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 467642..467661 /Source="Nicolas_upshift_promotors" /id="U336" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.976023976023976" /psig="0.998001998001998" /xcortree=2720 /SigmaFactorBS="cattttatttttttctctcagccaataagccTCTTTACAacg tgcgggaacggGAGTATGATCTCTTTTAGAAaacaaatcgcttaatctgaaatcagag c" /listShort="NA, S142, ydaO, mutT, ydaP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 467649 /Source="Nicolas_upshifts" /id="U336" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.976023976023976" /psig="0.998001998001998" /xcortree=2720 /SigmaFactorBS="cattttatttttttctctcagccaataagccTCTTTACAacg tgcgggaacggGAGTATGATCTCTTTTAGAAaacaaatcgcttaatctgaaatcagag c" /listShort="NA, S142, ydaO, mutT, ydaP" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 467659..467802 /gene="swaO" /locus_tag="BSU_misc_RNA_7" /product="ATP-, cyclic di-AMP-sensing riboswitch" /experiment="publication(s) with functional evidences, PMID:15096624, 20511502, 23086297, 25086507, 25086509" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15096624, 20511502, 23086297, 25086507, 25086509; Product type n: RNA" /function="16.3: Control" /label="swaO RNA" gene 467659..467802 /gene="swaO" /locus_tag="BSU_misc_RNA_7" /label="swaO gene" downshifts 467800 /Source="Nicolas_upshifts" /id="D197" /incds=0 /nref=10 /ntot=52 /MaxReadThrough="7.43698" /MaxDrop="5.83561" /score="30.4392599" /energy="-14.7" /TU="U336" /idTUdmin="U336" /TUdmin="-4305" /isTUend="FALSE" /label="downshifts" S_feature 467845..467998 /Source="Nicolas_S_feature" /locus_tag="new_486278_486431" /HighExp="LPhT, LBGstat, LPh, T-1.10H, T-0.40H, G135, G180, T-1.40H, G150, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S142" CDS 467999..469822 /gene="kimA" /locus_tag="BSU_04320" /old_locus_tag="BSU04320" /function="16.3: Control" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15096624, 15849754, 16850406, 20511502, 25086509, 26789423, 28420751" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15096624, 15849754, 16850406, 20511502, 25086509, 26789423, 28420751; Product type t: transporter" /codon_start=1 /transl_table=11 /product="cyclic di-AMP controlled transporter of potassium" /protein_id="NP_388313.1" /db_xref="EnsemblGenomes-Gn:BSU04320" /db_xref="EnsemblGenomes-Tr:CAB12239" /db_xref="GOA:P96589" /db_xref="InterPro:IPR002293" /db_xref="SubtiList:BG12062" /db_xref="UniProtKB/Swiss-Prot:P96589" /translation="MYHSIKRFLIGKPLKSQAAGEQKLTKLKALAMLSSDALSSVAYG TEQILIILATISAAAFWYSIPIAVGVLILLLALILSYRQIIYAYPQGGGAYIVSKENL GEKPGLIAGGSLLVDYILTVAVSISAGTDAITSAFPALHDYHVPIAIFLVLVIMILNL RGLSESASILAYPVYLFVVALLVLIAVGLFKLMTGQIDQPAHHTSLGTPVAGITLFLL LKAFSSGCSALTGVEAISNAIPAFKNPPARNAARTLAMMGILLAILFSGITVLAYGYG TAPKPDETVVSQIASETFGRNVFYYVIQGVTSLILVLAANTGFSAFPQLAFNLARDQY MPRMFTVRGDRLGFSNGIIFLGFASIVLIILFGGQTEHLIPLYAVGVFIPFTLSQTGM CMKWIKQKPKGWIGKMLINSCGALISFMVLSILFVTKFNVVWPVLIFMPIVVLLFFAI KNHYTAVGEQLRIVDKEPEEIKGTVVIVPVAGVTTVVQKSIHYAKSLSDQVIAVHVSF DREQEKKFEKRWEELNNGVRLVTLHSSYRSLVHPFDKFLETVEAKAKKEQFSVMVLFP QFITKKRWHTILHNQSAFLLRVRLFWKKDIMVATLPYHFKK*" /label="kimA CDS" gene 467999..469822 /gene="kimA" /locus_tag="BSU_04320" /old_locus_tag="BSU04320" /label="kimA gene" downshifts 469814 /Source="Nicolas_upshifts" /id="D198" /incds=0 /nref=50 /ntot=181 /MaxReadThrough="3.55206" /MaxDrop="4.7232" /score="6.00201196" /energy="-13.9" /TU="U336" /idTUdmin="U336" /TUdmin="-2291" /isTUend="FALSE" /label="downshifts" CDS 469881..470330 /gene="nudT" /locus_tag="BSU_04330" /old_locus_tag="BSU04330" /EC_number="3.6.1.-" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15576788, 16513759; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NTP pyrophosphohydrolase" /protein_id="NP_388314.1" /db_xref="EnsemblGenomes-Gn:BSU04330" /db_xref="EnsemblGenomes-Tr:CAB12240" /db_xref="GOA:P96590" /db_xref="InterPro:IPR000086" /db_xref="InterPro:IPR015797" /db_xref="InterPro:IPR020084" /db_xref="InterPro:IPR020476" /db_xref="SubtiList:BG11956" /db_xref="UniProtKB/Swiss-Prot:P96590" /translation="MYTQGAFVIVLNESQQILLVKRKDVPLWDLPGGRVDPGESAEEA AVREILEETGYNAALSAKIGVYQRPKFQDEQHLFFGSITGGQAMADGTETAGLKWVSP GRLPLFMVPNRKRQINDFKNGAQDVNVTVKDSGLLAAIDLLKRRLGK*" /label="nudT CDS" gene 469881..470330 /gene="nudT" /locus_tag="BSU_04330" /old_locus_tag="BSU04330" /label="nudT gene" promotor_-35 470343..470349 /Source="Nicolas_upshift_promotors" /id="U337" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=192 /SigmaFactorBS="tgttgaaaagaagactgggcaagtgattcaggtctccgGGTT TTAaagcctttctcctgTGGTATTGAAAAAAGGAAAaaggaggatacgttatggcaca c" /listShort="ydaP, S145" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 470364..470382 /Source="Nicolas_upshift_promotors" /id="U337" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=192 /SigmaFactorBS="tgttgaaaagaagactgggcaagtgattcaggtctccgGGTT TTAaagcctttctcctgTGGTATTGAAAAAAGGAAAaaggaggatacgttatggcaca c" /listShort="ydaP, S145" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 470365 /Source="Nicolas_upshifts" /id="U337" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=192 /SigmaFactorBS="tgttgaaaagaagactgggcaagtgattcaggtctccgGGTT TTAaagcctttctcctgTGGTATTGAAAAAAGGAAAaaggaggatacgttatggcaca c" /listShort="ydaP, S145" /GFF_Attribute="listLong" /label="upshifts" CDS 470397..472121 /gene="poxB" /locus_tag="BSU_04340" /old_locus_tag="BSU04340" /EC_number="1.2.3.3" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16291680, 16513748, 10220166, 23611909; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetyl-phosphate generating pyruvate oxidase" /protein_id="NP_388315.1" /db_xref="EnsemblGenomes-Gn:BSU04340" /db_xref="EnsemblGenomes-Tr:CAB12241" /db_xref="GOA:P96591" /db_xref="InterPro:IPR000399" /db_xref="InterPro:IPR011766" /db_xref="InterPro:IPR012000" /db_xref="InterPro:IPR012001" /db_xref="InterPro:IPR029035" /db_xref="InterPro:IPR029061" /db_xref="SubtiList:BG12063" /db_xref="UniProtKB/Swiss-Prot:P96591" /translation="MAHKTAGQAMTELLEQWGVDHVYGIPGDSINEFIEELRHERNQL KFIQTRHEEVAALAAAAEAKLTGKIGVCLSIAGPGAVHLLNGLYDAKADGAPVLAIAG QVSSGEVGRDYFQEIKLEQMFEDVAVFNREVHSAESLPDLLNQAIRTAYSKKGVAVLS VSDDLFAEKIKREPVYTSPVYIEGNLEPKKEQLVTCAQYINNAKKPIILAGQGMKKAK RELLEFADKAAAPIVVTLPAKGVVPDKHPHFLGNLGQIGTKPAYEAMEECDLLIMLGT SFPYRDYLPDDTPAIQLDSDPAKIGKRYPVTAGLVCDSALGLRELTEYIERKEDRRFL NACTEHMQHWWNEIEKDETEATTPLKPQQVVARLQEAAADDAVLSVDVGTVTVWMARH FKMNANQDFIVSSWLATMGCGLPGAIAASLSEPERQAIAVCGDGGFSMVMQDLPTAVK YKLPITVVILNNENLGMIEYEQQVKGNIDYVTKLQNVDYAAFAESCGAKGIKVTKAEE LAPAFHEALHSDQPVVVDVMIGNEPPLPGKITYGQAKGFSKYMLKNFFENQKFEMPSL KKSLKRLF*" /label="poxB CDS" gene 470397..472121 /gene="poxB" /locus_tag="BSU_04340" /old_locus_tag="BSU04340" /label="poxB gene" S_feature complement(471233..472092) /Source="Nicolas_S_feature" /locus_tag="new_489666_490525_c" /HighExp="H2O2, Paraq, G180, G150, Oxctl, Diami, dia15, G135, C30, dia5" /AntisenseName="ydaP" /AntisenseCor="-5.0529608261635599E-2" /AntisenseRegPval="-0.4" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, SigA" /TUshortPSig="0.113, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S143" S_feature complement(472094..472205) /Source="Nicolas_S_feature" /locus_tag="new_490527_490638_c" /HighExp="dia5, M0t45, S0, S2, S1, Paraq, GM 120, Lbstat, MG 5, UNK1" /AntisenseName="ydaP" /AntisenseCor="1.7026698118644101E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, SigA" /TUshortPSig="0.113, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S144" downshifts 472105 /Source="Nicolas_upshifts" /id="D199" /incds=0 /nref=50 /ntot=166 /MaxReadThrough="5.18566" /MaxDrop="6.66568" /score="7.55338633" /energy="-5.3" /TU="U337" /idTUdmin="U336" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(472113..472316) /locus_tag="BSU_04345" /old_locus_tag="BSU04345" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513943.1" /translation="MIRISMQGQMHLPLKQDAFVLLSVSSMAKSVPNTYTDHFMNSNM LKIHLFPKKKKKTRALRAPVFLK*" /label="hypothetical protein CDS" gene complement(472113..472316) /locus_tag="BSU_04345" /old_locus_tag="BSU04345" /label="gene" downshifts complement(472137) /Source="Nicolas_upshifts" /id="D200" /incds=0 /nref=5 /ntot=55 /MaxReadThrough="4.75809" /MaxDrop="8.06239" /score="11.2659249" /energy="-9.1" /TU="U338,U340,U341" /idTUdmin="U338" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" promotor_no_box complement(472165..472265) /Source="Nicolas_upshift_promotors" /id="U338" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.445554445554446" /psig="0.112887112887113" /xcortree=1496 /SigmaFactorBS="gcatttgtccttttgtctgtttcgagtatggcgaaatcagtt cctaatacatataccgatcattttatgaattcaaacatgctgaaaatacatttgtttc c" /listShort="S144, S143" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-35 472174..472179 /Source="Nicolas_upshift_promotors" /id="U339" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.914085914085914" /psig="0.914085914085914" /xcortree=1216 /SigmaFactorBS="tgtttttttttttttttttggaaacaaaTGTATTttcagcat gtttgaatTCATAAAATGATCGGTATAtgtattaggaactgatttcgccatactcgaa a" /listShort="S145" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 472196..472214 /Source="Nicolas_upshift_promotors" /id="U339" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.914085914085914" /psig="0.914085914085914" /xcortree=1216 /SigmaFactorBS="tgtttttttttttttttttggaaacaaaTGTATTttcagcat gtttgaatTCATAAAATGATCGGTATAtgtattaggaactgatttcgccatactcgaa a" /listShort="S145" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(472205) /Source="Nicolas_upshifts" /id="U338" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.445554445554446" /psig="0.112887112887113" /xcortree=1496 /SigmaFactorBS="gcatttgtccttttgtctgtttcgagtatggcgaaatcagtt cctaatacatataccgatcattttatgaattcaaacatgctgaaaatacatttgtttc c" /listShort="S144, S143" /GFF_Attribute="listLong" /label="upshifts" S_feature 472206..472421 /Source="Nicolas_S_feature" /locus_tag="new_490639_490854" /HighExp="Etha, S4, S8, S5, C30, S7, B60, S6, Salt, B36" /AntisenseName="ydzK" /AntisenseCor="3.8830946787094797E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigB" /TUshortPSig="0.914, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S145" upshifts 472206 /Source="Nicolas_upshifts" /id="U339" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.914085914085914" /psig="0.914085914085914" /xcortree=1216 /SigmaFactorBS="tgtttttttttttttttttggaaacaaaTGTATTttcagcat gtttgaatTCATAAAATGATCGGTATAtgtattaggaactgatttcgccatactcgaa a" /listShort="S145" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(472272..472343) /Source="Nicolas_S_feature" /locus_tag="new_490705_490776_c" /HighExp="Sw, B60, dia15, dia5, BI, Etha, BC, M9-stat, C90, M0t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S146" downshifts complement(472315) /Source="Nicolas_upshifts" /id="D201" /incds=0 /nref=21 /ntot=191 /MaxReadThrough="5.39949" /MaxDrop="5.81865" /score="3.34912028" /energy="-20.3" /TU="U340,U341" /idTUdmin="U343" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(472344..472610) /gene="ydzK" /locus_tag="BSU_04359" /old_locus_tag="BSU04359" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="YP_003097680.1" /db_xref="EnsemblGenomes-Gn:BSU04359" /db_xref="EnsemblGenomes-Tr:CAX52551" /db_xref="GOA:C0H3V4" /db_xref="UniProtKB/Swiss-Prot:C0H3V4" /translation="MSVFILFYLWIVPIVIGILCSVAAHKSKGKMRVAPGIAMIVLSI ISLITAFTAGHTNFHVFIGGMFLFGTFLVGSAFPFFFGLKKKEK*" /label="ydzK CDS" gene complement(472344..472610) /gene="ydzK" /locus_tag="BSU_04359" /old_locus_tag="BSU04359" /label="ydzK gene" promotor_-10 complement(472626..472645) /Source="Nicolas_upshift_promotors" /id="U340" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.637362637362637" /psig=1 /xcortree=2076 /SigmaFactorBS="cttctaaagccggtttttatttttccgcaaaagctcattgAT ACCCTTtttgacagaaaTTTGTTATGATAGAAGAAAAatcggagttttgatgatgtca g" /listShort="ydzK, S146, S144, S143" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(472644) /Source="Nicolas_upshifts" /id="U340" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.637362637362637" /psig=1 /xcortree=2076 /SigmaFactorBS="cttctaaagccggtttttatttttccgcaaaagctcattgAT ACCCTTtttgacagaaaTTTGTTATGATAGAAGAAAAatcggagttttgatgatgtca g" /listShort="ydzK, S146, S144, S143" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(472657..472664) /Source="Nicolas_upshift_promotors" /id="U340" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.637362637362637" /psig=1 /xcortree=2076 /SigmaFactorBS="cttctaaagccggtttttatttttccgcaaaagctcattgAT ACCCTTtttgacagaaaTTTGTTATGATAGAAGAAAAatcggagttttgatgatgtca g" /listShort="ydzK, S146, S144, S143" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(472714..473991) /gene="mntH" /locus_tag="BSU_04360" /old_locus_tag="BSU04360" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12029030, 12950915, 14580210, 15849754, 16850406, 27573840, 27748968" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12029030, 12950915, 14580210, 15849754, 16850406, 27573840, 27748968; Product type t: transporter" /codon_start=1 /transl_table=11 /product="proton-coupled manganese transporter" /protein_id="NP_388317.1" /db_xref="EnsemblGenomes-Gn:BSU04360" /db_xref="EnsemblGenomes-Tr:CAB12243" /db_xref="GOA:P96593" /db_xref="InterPro:IPR001046" /db_xref="SubtiList:BG12065" /db_xref="UniProtKB/Swiss-Prot:P96593" /translation="MMNKDITAQSPRSKAVQDALDGKIRGFRGLLPFLGPAFIAAIAY IDPGNFATNISAGSKYGYMLLWVILFSNIMALLIQSLSAKLGIATGKNLPEVAREEFP KPVSIGLWIQGELVIIATDLAEFIGAALGLYLLFGIPMLEASIIAAIGSFAILELQRR GYRSLEAGIAGMLFVVVIAFALQTFFAKPDAVSVMKGLFVPAFHGTDSVLLAAGILGA TVMPHAIYLHSALTQRRVVGKTDAERKKIFRFEFIDILIAMLIAGAINASMLIVAAAL FFKNGLFVEDLDVAFQQFGHLVSPMSAALFGIGLLVAGLSSSSVGTLSGDVIMQGFIN YRIPLYVRRFITIIPPILIIASGVNPTTALVLSQVVLSFGIAFALIPLIMFTSNKRIM GSLINAKWITVVSWLIAVLIVALNVFLIVDTFR*" /label="mntH CDS" gene complement(472714..473991) /gene="mntH" /locus_tag="BSU_04360" /old_locus_tag="BSU04360" /label="mntH gene" downshifts complement(472733) /Source="Nicolas_upshifts" /id="D202" /incds=0 /nref=170 /ntot=242 /MaxReadThrough="5.8826" /MaxDrop="4.8109" /score="28.3182556" /energy="-9.6" /TU="U341,U343" /idTUdmin="U342" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(474053..474072) /Source="Nicolas_upshift_promotors" /id="U341" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig=1 /xcortree=1525 /SigmaFactorBS="ggaaaaattcagaagtgtattttgaacattttcGGTTGACAa gaaaccgggatGGTCATATGATGTAGATAAAataatttgccttaaggaaactctttgt t" /listShort="mntH, ydzK, S146, S144, S143" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(474065) /Source="Nicolas_upshifts" /id="U341" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig=1 /xcortree=1525 /SigmaFactorBS="ggaaaaattcagaagtgtattttgaacattttcGGTTGACAa gaaaccgggatGGTCATATGATGTAGATAAAataatttgccttaaggaaactctttgt t" /listShort="mntH, ydzK, S146, S144, S143" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(474067..474144) /Source="Nicolas_S_feature" /locus_tag="new_492500_492577_c" /HighExp="S6, S8, S7, Etha, S5, Salt, BT, Heat, B36, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigB" /TUshortPSig="1, 0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S147" promotor_-35 complement(474085..474092) /Source="Nicolas_upshift_promotors" /id="U341" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig=1 /xcortree=1525 /SigmaFactorBS="ggaaaaattcagaagtgtattttgaacattttcGGTTGACAa gaaaccgggatGGTCATATGATGTAGATAAAataatttgccttaaggaaactctttgt t" /listShort="mntH, ydzK, S146, S144, S143" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(474128..474147) /Source="Nicolas_upshift_promotors" /id="U342" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1312 /SigmaFactorBS="aggcatcgtttcgaaatgaaacgatgtctttttaTATGGGAC CTtatcacgaatcccTACATATCATGTTACATAACagggaaaaattcagaagtgtatt t" /listShort="S147, mntH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(474144) /Source="Nicolas_upshifts" /id="U342" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1312 /SigmaFactorBS="aggcatcgtttcgaaatgaaacgatgtctttttaTATGGGAC CTtatcacgaatcccTACATATCATGTTACATAACagggaaaaattcagaagtgtatt t" /listShort="S147, mntH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(474161..474170) /Source="Nicolas_upshift_promotors" /id="U342" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1312 /SigmaFactorBS="aggcatcgtttcgaaatgaaacgatgtctttttaTATGGGAC CTtatcacgaatcccTACATATCATGTTACATAACagggaaaaattcagaagtgtatt t" /listShort="S147, mntH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(474221..474478) /gene="ydaS" /locus_tag="BSU_04370" /old_locus_tag="BSU04370" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388318.1" /db_xref="EnsemblGenomes-Gn:BSU04370" /db_xref="EnsemblGenomes-Tr:CAB12244" /db_xref="GOA:P96594" /db_xref="InterPro:IPR007341" /db_xref="SubtiList:BG12066" /db_xref="UniProtKB/Swiss-Prot:P96594" /translation="MLSFLVSLVVAIVIGLIGSAIVGNRLPGGIFGSMIAGLIGAWIG HGLLGTWGPSLAGFAIFPAIIGAAIFVFLLGLIFRGLRKEA*" /label="ydaS CDS" gene complement(474221..474478) /gene="ydaS" /locus_tag="BSU_04370" /old_locus_tag="BSU04370" /label="ydaS gene" downshifts complement(474229) /Source="Nicolas_upshifts" /id="D203" /incds=0 /nref=7 /ntot=33 /MaxReadThrough="4.70076" /MaxDrop="4.7213" /score="7.04635537" /energy="-13.4" /TU="U343" /idTUdmin="U342" /TUdmin="-1496" /isTUend="FALSE" /label="downshifts" downshifts complement(474295) /Source="Nicolas_upshifts" /id="D204" /incds=1 /nref=2 /ntot=69 /MaxReadThrough="7.55545" /MaxDrop="2.8244" /score="7.04635537" /energy="-13.4" /TU="U343" /idTUdmin="U342" /TUdmin="-1562" /isTUend="FALSE" /label="downshifts" CDS complement(474556..475008) /gene="ydaT" /locus_tag="BSU_04380" /old_locus_tag="BSU04380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388319.1" /db_xref="EnsemblGenomes-Gn:BSU04380" /db_xref="EnsemblGenomes-Tr:CAB12245" /db_xref="InterPro:IPR018691" /db_xref="SubtiList:BG12067" /db_xref="UniProtKB/Swiss-Prot:P96595" /translation="MPWSMKDYPASLKNLEKPVRKKAIDIANAMIDEGYEEGRAIPIA TSKAKEWAENASTDEIDDFLTHDDETERDADPSSGSGPELMNKAEHVIKHKKGWAVKA EGAKRVSEIKDTKKEAIERAKEIAAHKGTEVIVHLADGSVQRKIKTGS*" /label="ydaT CDS" gene complement(474556..475008) /gene="ydaT" /locus_tag="BSU_04380" /old_locus_tag="BSU04380" /label="ydaT gene" promotor_-10 complement(475027..475045) /Source="Nicolas_upshift_promotors" /id="U343" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=230 /SigmaFactorBS="ttttttctactatatagtataccttcattttttcggatgCGT TTTTatttttcacctgcGGGTACCATTTTTATAAAAggaaaaggagtgatagacatgc c" /listShort="ydaT, ydaS, S147, mntH, ydzK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(475044) /Source="Nicolas_upshifts" /id="U343" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=230 /SigmaFactorBS="ttttttctactatatagtataccttcattttttcggatgCGT TTTTatttttcacctgcGGGTACCATTTTTATAAAAggaaaaggagtgatagacatgc c" /listShort="ydaT, ydaS, S147, mntH, ydzK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(475059..475065) /Source="Nicolas_upshift_promotors" /id="U343" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=230 /SigmaFactorBS="ttttttctactatatagtataccttcattttttcggatgCGT TTTTatttttcacctgcGGGTACCATTTTTATAAAAggaaaaggagtgatagacatgc c" /listShort="ydaT, ydaS, S147, mntH, ydzK" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 475077 /Source="Nicolas_upshifts" /id="U344" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.795204795204795" /psig="0.993006993006993" /xcortree=2375 /SigmaFactorBS="ctccttttccttttataaaaatggtacccgcaggtgaaaaat aaaaacgcatccgaaaaaatgaaggtATACTATATAGTAGAAAAAAcggaagggaagt g" /listShort="ydbA" /GFF_Attribute="listLong" /label="upshifts" misc_feature 475085..475104 /Source="Nicolas_upshift_promotors" /id="U344" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.795204795204795" /psig="0.993006993006993" /xcortree=2375 /SigmaFactorBS="ctccttttccttttataaaaatggtacccgcaggtgaaaaat aaaaacgcatccgaaaaaatgaaggtATACTATATAGTAGAAAAAAcggaagggaagt g" /listShort="ydbA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 475126..475944 /gene="ydbA" /locus_tag="BSU_04390" /old_locus_tag="BSU04390" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388320.1" /db_xref="EnsemblGenomes-Gn:BSU04390" /db_xref="EnsemblGenomes-Tr:CAB12246" /db_xref="InterPro:IPR024787" /db_xref="SubtiList:BG12068" /db_xref="UniProtKB/Swiss-Prot:P96596" /translation="MPTERKEDLHQQLKEIEKWEKDQQKVWFWEKLSRLPFQLLDKLT PEFIQKKIGKLLDEVGSFVQTGGQYLTSEKQIIRMFQKKLPEEIFESLEDIRKAPLPV MDEIAEGMGKNRTNAATVQGATTGVGGVFTLAADIPAVLGLSLKTLQDIAVAYGYDPK EKKERVFIVKCLQLTSADVVGKRSILQELKHYDQDRTYKNVASQIQGWREVVLGYRDT FGWKKLFQIVPVAGMVFGAAANRSTLNDITETGMMLYKKRRILERLKETEREME*" /label="ydbA CDS" gene 475126..475944 /gene="ydbA" /locus_tag="BSU_04390" /old_locus_tag="BSU04390" /label="ydbA gene" downshifts 475935 /Source="Nicolas_upshifts" /id="D205" /incds=0 /nref=118 /ntot=223 /MaxReadThrough="0.66117" /MaxDrop="4.41502" /score="5.38936313" /energy="-9.2" /TU="NA" /idTUdmin="U344" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 476012..476018 /Source="Nicolas_upshift_promotors" /id="U345" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=219 /SigmaFactorBS="ttttagtggaaacatacccaatgtgttttgttTGTTTAAaag aattgtgagcGGGAATACAACAACCAACAccaattaaaggaggaattcaaaatggcag a" /listShort="gsiB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 476032..476050 /Source="Nicolas_upshift_promotors" /id="U345" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=219 /SigmaFactorBS="ttttagtggaaacatacccaatgtgttttgttTGTTTAAaag aattgtgagcGGGAATACAACAACCAACAccaattaaaggaggaattcaaaatggcag a" /listShort="gsiB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 476040 /Source="Nicolas_upshifts" /id="U345" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=219 /SigmaFactorBS="ttttagtggaaacatacccaatgtgttttgttTGTTTAAaag aattgtgagcGGGAATACAACAACCAACAccaattaaaggaggaattcaaaatggcag a" /listShort="gsiB" /GFF_Attribute="listLong" /label="upshifts" CDS 476073..476444 /gene="gsiB" /locus_tag="BSU_04400" /old_locus_tag="BSU04400" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7651322, 9669336, 9763714, 12562800, 21421783" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7651322, 9669336, 9763714, 12562800, 21421783; Product type f: factor" /codon_start=1 /transl_table=11 /product="general stress protein glucose starvation induced" /protein_id="NP_388321.1" /db_xref="EnsemblGenomes-Gn:BSU04400" /db_xref="EnsemblGenomes-Tr:CAB12247" /db_xref="InterPro:IPR019626" /db_xref="SubtiList:BG10826" /db_xref="UniProtKB/Swiss-Prot:P26907" /translation="MADNNKMSREEAGRKGGETTSKNHDKEFYQEIGQKGGEATSKNH DKEFYQEIGEKGGEATSKNHDKEFYQEIGEKGGEATSENHDKEFYQEIGRKGGEATSK NHDKEFYQEIGSKGGNARNND*" /label="gsiB CDS" gene 476073..476444 /gene="gsiB" /locus_tag="BSU_04400" /old_locus_tag="BSU04400" /label="gsiB gene" downshifts complement(476077) /Source="Nicolas_upshifts" /id="D206" /incds=0 /nref=1 /ntot=25 /MaxReadThrough="1.50212" /MaxDrop="4.6705" /score="-7.76438364" /energy="-14.2" /TU="NA" /idTUdmin="U346" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 476461 /Source="Nicolas_upshifts" /id="D207" /incds=0 /nref=153 /ntot=219 /MaxReadThrough="3.75525" /MaxDrop="8.3301" /score="39.7307477" /energy="-16.6" /TU="U345" /idTUdmin="U345" /TUdmin="-24" /isTUend="FALSE" /label="downshifts" upshifts complement(476495) /Source="Nicolas_upshifts" /id="U346" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.738261738261738" /psig="0.00899100899100899" /xcortree=120 /SigmaFactorBS="cttattgtatctcaatagcggcataaattgagaagattccaa aaaaaagcgatcCAGCtgatgtgccggatcgcttttttatttacaggttgtctgcctt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(476498..476501) /Source="Nicolas_upshift_promotors" /id="U346" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.738261738261738" /psig="0.00899100899100899" /xcortree=120 /SigmaFactorBS="cttattgtatctcaatagcggcataaattgagaagattccaa aaaaaagcgatcCAGCtgatgtgccggatcgcttttttatttacaggttgtctgcctt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-35 476523..476530 /Source="Nicolas_upshift_promotors" /id="U347" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=2941 /SigmaFactorBS="ggcacatcagctggatcgcttttttttggaatctTCTCAATT tatgccgctatTGAGATACAATAAGTGAAAAaggggttttcgctaatgtccaagatgc a" /listShort="ydbB, ydbC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 476542..476561 /Source="Nicolas_upshift_promotors" /id="U347" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=2941 /SigmaFactorBS="ggcacatcagctggatcgcttttttttggaatctTCTCAATT tatgccgctatTGAGATACAATAAGTGAAAAaggggttttcgctaatgtccaagatgc a" /listShort="ydbB, ydbC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 476549 /Source="Nicolas_upshifts" /id="U347" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=2941 /SigmaFactorBS="ggcacatcagctggatcgcttttttttggaatctTCTCAATT tatgccgctatTGAGATACAATAAGTGAAAAaggggttttcgctaatgtccaagatgc a" /listShort="ydbB, ydbC" /GFF_Attribute="listLong" /label="upshifts" CDS 476576..476917 /gene="ydbB" /locus_tag="BSU_04410" /old_locus_tag="BSU04410" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10704478; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme; cupin family" /protein_id="NP_388322.1" /db_xref="EnsemblGenomes-Gn:BSU04410" /db_xref="EnsemblGenomes-Tr:CAB12248" /db_xref="GOA:P96597" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR013096" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR019780" /db_xref="SubtiList:BG12069" /db_xref="UniProtKB/Swiss-Prot:P96597" /translation="MSKMQNLLAIANEVKEKHANFSISEVNDHCVRLAVFTGEYDWHH HPDSDELFIVLEGELLIDFKDKETAVLKANDSLLIPKGTVHRTRSYVRTVNLCVEHKQ AETVIIEEQPC*" /label="ydbB CDS" gene 476576..476917 /gene="ydbB" /locus_tag="BSU_04410" /old_locus_tag="BSU04410" /label="ydbB gene" CDS 476911..477270 /gene="ydbC" /locus_tag="BSU_04420" /old_locus_tag="BSU04420" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388323.1" /db_xref="EnsemblGenomes-Gn:BSU04420" /db_xref="EnsemblGenomes-Tr:CAB12249" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR032555" /db_xref="SubtiList:BG12070" /db_xref="UniProtKB/Swiss-Prot:P96598" /translation="MLIKKMICEVDAANAEAFAKAQSQWEALSHISGFIKQAGGWRKT IDEPLTAEIISVWENREAYDHFMENEHDSIYEENDQKAVILSIEVTVYEEDKPFVHDL LHNPDIRYEPNWTVLKA*" /label="ydbC CDS" gene 476911..477270 /gene="ydbC" /locus_tag="BSU_04420" /old_locus_tag="BSU04420" /label="ydbC gene" S_feature complement(476973..477266) /Source="Nicolas_S_feature" /locus_tag="new_495406_495699_c" /HighExp="Etha, Salt, M9-stat, C30, Heat, Sw, B60, S8, C90, UNK1" /AntisenseName="ydbC" /AntisenseCor="0.16172626521480701" /AntisenseRegPval="-2.1" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S148" downshifts 477211 /Source="Nicolas_upshifts" /id="D208" /incds=0 /nref=2 /ntot=130 /MaxReadThrough="1.8663" /MaxDrop="2.67081" /score="39.7307477" /energy="-16.6" /TU="NA" /idTUdmin="U347" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 477255 /Source="Nicolas_upshifts" /id="D209" /incds=0 /nref=1 /ntot=28 /MaxReadThrough="0.252220000000001" /MaxDrop="2.61185" /score="39.7307477" /energy="-16.6" /TU="NA" /idTUdmin="U347" /TUdmin=44 /isTUend="FALSE" /label="downshifts" CDS complement(477307..478128) /gene="ydbD" /locus_tag="BSU_04430" /old_locus_tag="BSU04430" /EC_number="1.11.1.6" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15231799; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative manganese-containing catalase" /protein_id="NP_388324.1" /db_xref="EnsemblGenomes-Gn:BSU04430" /db_xref="EnsemblGenomes-Tr:CAB12250" /db_xref="GOA:P80878" /db_xref="InterPro:IPR007760" /db_xref="InterPro:IPR009078" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR027407" /db_xref="SubtiList:BG12071" /db_xref="UniProtKB/Swiss-Prot:P80878" /translation="MFKHTKMLQHPAKPDRPDPLFAKKMQEILGGQFGEISVAMQYLF QGWNTRGNEKYKDLLMDTATEELGHVEMIATMIARLLEDAPLDQQEKAAEDPVIGSIL GGMNPHHAIVSGLGAMPESSTGVPWSGGYIVASGNLLADFRANLNAESQGRLQVARLF EMTDDKGVKDMLSFLLARDTMHQNQWLAAIKELEAQEGPVVPGTFPKALEKQEFSHQL INFSEGEVSAEQNWLNEKAPDGEAFEYVKEAKTFGEKPELKPAPPFVHNTLPGRE*" /label="ydbD CDS" gene complement(477307..478128) /gene="ydbD" /locus_tag="BSU_04430" /old_locus_tag="BSU04430" /label="ydbD gene" downshifts complement(477311) /Source="Nicolas_upshifts" /id="D210" /incds=0 /nref=62 /ntot=214 /MaxReadThrough="4.23505" /MaxDrop="6.82771" /score="-6.55917314" /energy="-13.1" /TU="U348" /idTUdmin="U348" /TUdmin="-310" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(478150..478168) /Source="Nicolas_upshift_promotors" /id="U348" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=193 /SigmaFactorBS="gctgcgaaaagattcatagttcccatctcgatacgctgtttt tCGTTTATctttctatcgatcGGAAATATAAAAAGAGATAaacgaaaaaggagatggg t" /listShort="ydbD, S148" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(478171) /Source="Nicolas_upshifts" /id="U348" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=193 /SigmaFactorBS="gctgcgaaaagattcatagttcccatctcgatacgctgtttt tCGTTTATctttctatcgatcGGAAATATAAAAAGAGATAaacgaaaaaggagatggg t" /listShort="ydbD, S148" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(478182..478188) /Source="Nicolas_upshift_promotors" /id="U348" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=193 /SigmaFactorBS="gctgcgaaaagattcatagttcccatctcgatacgctgtttt tCGTTTATctttctatcgatcGGAAATATAAAAAGAGATAaacgaaaaaggagatggg t" /listShort="ydbD, S148" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(478213..479265) /gene="dctB" /locus_tag="BSU_04440" /old_locus_tag="BSU04440" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:1809844, 10708364, 11566984, 24375102" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1809844, 10708364, 11566984, 24375102; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="membrane bound C4-dicarboxylate binding sensor protein" /protein_id="NP_388325.1" /db_xref="EnsemblGenomes-Gn:BSU04440" /db_xref="EnsemblGenomes-Tr:CAB12251" /db_xref="GOA:P96600" /db_xref="InterPro:IPR004682" /db_xref="InterPro:IPR018389" /db_xref="SubtiList:BG12072" /db_xref="UniProtKB/Swiss-Prot:P96600" /translation="MKSLLACLALMIAGIATALFIGFHDHTGNKKIVYDDDQEGLQDQ IVFKFSHVVAENTPKGLAANKFADLVNEKSGGKIKIEVFPNGSLYSDIEEIEALQNGD VQFIAPSTSKLGMLSPEWGVLDLPYAFTDYNAVKKGLNGSIGTQLFDSLKKNQLKGLA YWTNGFKQITTNQGPVKTPDDLKGQDLRIMQSDVIEDQFKLLGATPHQESFNSTFQLL ENNVVDGEENTISNIYSKKFYNVQDYLTISSHGYLGYAVMTDEHFWKAQTPETRRILT EAMKETTEWNETYAEQMNKEQLEEIKKNSAIHIYELSDKEKQEWMKRLDPVYRQYEPI FGRELIRELLELRKDS*" /label="dctB CDS" gene complement(478213..479265) /gene="dctB" /locus_tag="BSU_04440" /old_locus_tag="BSU04440" /label="dctB gene" promotor_-35 478525..478532 /Source="Nicolas_upshift_promotors" /id="U349" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.882117882117882" /psig=1 /xcortree=1811 /SigmaFactorBS="cagtcatgacagcgtagccgagataaccgtggctgctTATTG TCAaatagtcctgaacaTTATAAAATTTTTTAGAATAgatgtttgaaattgtattttc t" /listShort="S149, dctS" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 478547..479334 /Source="Nicolas_S_feature" /locus_tag="new_496980_497767" /HighExp="LBGstat, Diami, T-0.40H, T0.0H, T0.30H, Heat, UNK1, GM-0.1, MG 90, Fru" /AntisenseName="dctB" /AntisenseCor="0.64205060306327899" /AntisenseRegPval="-31.9" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S149" promotor_-10 478547..478566 /Source="Nicolas_upshift_promotors" /id="U349" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.882117882117882" /psig=1 /xcortree=1811 /SigmaFactorBS="cagtcatgacagcgtagccgagataaccgtggctgctTATTG TCAaatagtcctgaacaTTATAAAATTTTTTAGAATAgatgtttgaaattgtattttc t" /listShort="S149, dctS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 478548 /Source="Nicolas_upshifts" /id="U349" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.882117882117882" /psig=1 /xcortree=1811 /SigmaFactorBS="cagtcatgacagcgtagccgagataaccgtggctgctTATTG TCAaatagtcctgaacaTTATAAAATTTTTTAGAATAgatgtttgaaattgtattttc t" /listShort="S149, dctS" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(479278..479297) /Source="Nicolas_upshift_promotors" /id="U350" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig="0.937062937062937" /xcortree=1551 /SigmaFactorBS="tttgttcatcagcttctcctttcagGTCTTTACgaatgtcat agccCCCATTATCCTTAACATAGGggagggcttttcatgaagagtttgcttgcatgtc t" /listShort="dctB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(479283) /Source="Nicolas_upshifts" /id="U350" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig="0.937062937062937" /xcortree=1551 /SigmaFactorBS="tttgttcatcagcttctcctttcagGTCTTTACgaatgtcat agccCCCATTATCCTTAACATAGGggagggcttttcatgaagagtttgcttgcatgtc t" /listShort="dctB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(479311..479318) /Source="Nicolas_upshift_promotors" /id="U350" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig="0.937062937062937" /xcortree=1551 /SigmaFactorBS="tttgttcatcagcttctcctttcagGTCTTTACgaatgtcat agccCCCATTATCCTTAACATAGGggagggcttttcatgaagagtttgcttgcatgtc t" /listShort="dctB" /GFF_Attribute="listLong" /label="promotor_-35" CDS 479335..480942 /gene="dctS" /locus_tag="BSU_04450" /old_locus_tag="BSU04450" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:10627041, 11717295, 1290636, 12949159, 24375102" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10627041, 11717295, 1290636, 12949159, 24375102; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase" /protein_id="NP_388326.1" /db_xref="EnsemblGenomes-Gn:BSU04450" /db_xref="EnsemblGenomes-Tr:CAB12252" /db_xref="GOA:P96601" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR016120" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR033463" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12073" /db_xref="UniProtKB/Swiss-Prot:P96601" /translation="MNKKKLSIRWKITILSYILVIFSFLIGGIVLIGNIQHTEERELK KRLMNTARTVSEMTEVKEALARKKQTEAVRHAVEEIRMINEADYIVVMDMNHIRYTHP VSTSIGKKSEGADEEAAFAEHIYFSEAKGEIGTAVRAFYPVKDQDLNQIGVVLVGKTL PGIADILLHLKRDIAFIVVLTLGFGLAGSFLLARHIKKQMFQLEPHEIVRMYEERTAT FHSMNEGVIAIDNRLVITIFNEKAKQIFEVQGDLIGKVIWEVLKDSRLPEIVERNKAV YNEEIRVSGKVIMSSRIPIVMKKKVIGAVAIFQDRTEAAKMAEELTGVRNFVEALRVQ NHEHMNKLHTIAGLIQLGKSEKALQLAFQASTEQENVTEFLHRSIQNDAAAGLLLSKI RRGRELGIAVHIDENSSLQQFPEHVDQHDIVVLLGNLIENAFGSFETVQSEDKRIDIS IEQTDDILAILIEDNGCGIEPTHMPRLYDKGFTVNKTGGTGYGLYLVKQIIDKGSGTI EVDSHAGQGTSFSIVFPMKGEEAQHGS*" /label="dctS CDS" gene 479335..480942 /gene="dctS" /locus_tag="BSU_04450" /old_locus_tag="BSU04450" /label="dctS gene" CDS 480932..481612 /gene="dctR" /locus_tag="BSU_04460" /old_locus_tag="BSU04460" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10627041, 11717295, 1290636, 12949159" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10627041, 11717295, 1290636, 12949159; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator" /protein_id="NP_388327.1" /db_xref="EnsemblGenomes-Gn:BSU04460" /db_xref="EnsemblGenomes-Tr:CAB12253" /db_xref="GOA:P96602" /db_xref="InterPro:IPR001034" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR024187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12074" /db_xref="UniProtKB/Swiss-Prot:P96602" /translation="MARKEWKVLLIEDDPMVQEVNKDFITTVKGVTVCATAGNGEEGM KLIKEEQPDLVILDVYMPKKDGIKTLQEIRKQKLEVDVIVVSAAKDKETISLMLQNGA VDYILKPFKLERMRQALEKYKQYKQKIEANDTLSQEQLDAILNIPQQAVQDLPKGLNH FTMNEVTAFLKQQTASLSAEEVAKALGIARVTARRYLDYLEKTGIIKLDVQYGGVGRP VNRYVLKG*" /label="dctR CDS" gene 480932..481612 /gene="dctR" /locus_tag="BSU_04460" /old_locus_tag="BSU04460" /label="dctR gene" S_feature 481613..481687 /Source="Nicolas_S_feature" /locus_tag="new_500046_500120" /HighExp="Sw, Diami, Mt0, G150, BI, Lbstat, M40t45, Lbtran, Mal, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S150" promotor_-35 481654..481661 /Source="Nicolas_upshift_promotors" /id="U351" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.450549450549451" /psig="0.96003996003996" /xcortree=1558 /SigmaFactorBS="accaaaatgtccgttatgatcataaACTTCCCCagactgtat gaaaaCGCTATCATTCTAGTAAGaaagacacaaaaggcgaataggacagggggatgaa g" /listShort="dctP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 481676..481693 /Source="Nicolas_upshift_promotors" /id="U351" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.450549450549451" /psig="0.96003996003996" /xcortree=1558 /SigmaFactorBS="accaaaatgtccgttatgatcataaACTTCCCCagactgtat gaaaaCGCTATCATTCTAGTAAGaaagacacaaaaggcgaataggacagggggatgaa g" /listShort="dctP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 481689 /Source="Nicolas_upshifts" /id="U351" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.450549450549451" /psig="0.96003996003996" /xcortree=1558 /SigmaFactorBS="accaaaatgtccgttatgatcataaACTTCCCCagactgtat gaaaaCGCTATCATTCTAGTAAGaaagacacaaaaggcgaataggacagggggatgaa g" /listShort="dctP" /GFF_Attribute="listLong" /label="upshifts" CDS 481733..482998 /gene="dctP" /locus_tag="BSU_04470" /old_locus_tag="BSU04470" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10627041, 10708364, 12949159, 15849754, 16850406, 20363944, 22389480" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10627041, 10708364, 12949159, 15849754, 16850406, 20363944, 22389480; Product type t: transporter" /codon_start=1 /transl_table=11 /product="C4-dicarboxylate transport protein" /protein_id="NP_388328.1" /db_xref="EnsemblGenomes-Gn:BSU04470" /db_xref="EnsemblGenomes-Tr:CAB12254" /db_xref="GOA:P96603" /db_xref="InterPro:IPR001991" /db_xref="InterPro:IPR018107" /db_xref="InterPro:IPR023954" /db_xref="InterPro:IPR036458" /db_xref="SubtiList:BG12075" /db_xref="UniProtKB/Swiss-Prot:P96603" /translation="MKLFKNLTVQVITAVIIGVIVGLVWPDVGKEMKPLGDTFINAVK MVIAPIIFFTIVLGIAKMGDMKKVGKVGGKAFIYFEVVTTLALIIGLFVVNIMKPGAG LDYSKLEKGDVSQYTQNGGQGIDWIEFITHIVPSNMVDAFAKGDILQVLFFSILFGVG LAALGEKGKSVIDFFDKVSHVFFKIIGYIMRAAPIGAFGAMAYTIGHFGLDSIKPLAS LMMSVYITMFLFVFVALNIICKLYGFSLWNYLRFIKDELLIVLGTSSSESVLPRMMDK MERYGCSKSVVGLVIPTGYSFNLDGTSIYLSMATVFLAQVFGVDLSIGQQITIILVLM LTSKGAAGVTGSGFIVLASTLSALQVIPLEGLALLLGVDRFMSEGRAIVNLIGNGIAT IIVAKSENEFDEAKSIEAVEGMKKMKTAV*" /label="dctP CDS" gene 481733..482998 /gene="dctP" /locus_tag="BSU_04470" /old_locus_tag="BSU04470" /label="dctP gene" downshifts 482991 /Source="Nicolas_upshifts" /id="D211" /incds=0 /nref=175 /ntot=235 /MaxReadThrough="3.99042" /MaxDrop="7.04798" /score="45.0636559" /energy="-12.6" /TU="NA" /idTUdmin="U351" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(483045) /Source="Nicolas_upshifts" /id="D212" /incds=0 /nref=1 /ntot=9 /MaxReadThrough="0.588190000000001" /MaxDrop="3.06255" /score="19.3433396" /energy="-12.6" /TU="NA" /idTUdmin="U350" /TUdmin="-4818" /isTUend="FALSE" /label="downshifts" misc_feature 483082..483099 /Source="Nicolas_upshift_promotors" /id="U352" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.423576423576424" /psig="0.483516483516484" /xcortree=1457 /SigmaFactorBS="gtttttttaattgtttaagaattattaaggtaaggacagaga cctcagcatttttttgTTATATAATTTACAAATGgatactatattgaatgaaggacgt t" /listShort="ydbI, S151, ydbJ, ydbK, ydbL, S152, ydbM" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 483084 /Source="Nicolas_upshifts" /id="U352" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.423576423576424" /psig="0.483516483516484" /xcortree=1457 /SigmaFactorBS="gtttttttaattgtttaagaattattaaggtaaggacagaga cctcagcatttttttgTTATATAATTTACAAATGgatactatattgaatgaaggacgt t" /listShort="ydbI, S151, ydbJ, ydbK, ydbL, S152, ydbM" /GFF_Attribute="listLong" /label="upshifts" CDS 483146..484198 /gene="ydbI" /locus_tag="BSU_04480" /old_locus_tag="BSU04480" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388329.1" /db_xref="EnsemblGenomes-Gn:BSU04480" /db_xref="EnsemblGenomes-Tr:CAB12255" /db_xref="GOA:P96604" /db_xref="InterPro:IPR002549" /db_xref="SubtiList:BG12076" /db_xref="UniProtKB/Swiss-Prot:P96604" /translation="MAALVKFFQHPGVRRFSIFVVLTGVLYLFKSMINLILLTFIFTF LMDRLELVVRQFVSQFFRVSQRVVITFLYMLLAVLLTVGGFVFYPVVAAQIQQLVKQI KHIAYHPDSIPFFDEITSVFGDINISSYVKEGFNVVYTYLADISTFGLQVVMALILSM FFLFEKKRLSEFMAKFKTSKLRVFYEEIAFFGSKFARTFGKVLEAQFIIALVNCILTF IALWIMHFPQLFGLSIMVFFLGLIPVAGVVISLIPLSIIAYSTGGGMYVLYIVLVIFA IHAIETYFLNPKLMSAKTELPIFFTFTVLIFSEHFFGIWGLIIGIPIFVFLLDILDVT NKEDRSKGPRENSDKK*" /label="ydbI CDS" gene 483146..484198 /gene="ydbI" /locus_tag="BSU_04480" /old_locus_tag="BSU04480" /label="ydbI gene" S_feature 484199..484442 /Source="Nicolas_S_feature" /locus_tag="new_502632_502875" /HighExp="S8, S5, S6, LoTm, S7, S3, LBGstat, LBGexp, Paraq, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.87223499999999998" /TUshortSig="Sig-" /TUshortPSig="0.484" /TUlongSig="NA" /TUlongPSig="NA" /label="S151" downshifts 484399 /Source="Nicolas_upshifts" /id="D213" /incds=0 /nref=6 /ntot=45 /MaxReadThrough="6.05001" /MaxDrop="3.52626" /score="17.6400305" /energy="-12.4" /TU="U352" /idTUdmin="U351" /TUdmin=1408 /isTUend="FALSE" /label="downshifts" CDS 484475..485401 /gene="ydbJ" /locus_tag="BSU_04490" /old_locus_tag="BSU04490" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding subunit)" /protein_id="NP_388330.1" /db_xref="EnsemblGenomes-Gn:BSU04490" /db_xref="EnsemblGenomes-Tr:CAB12256" /db_xref="GOA:P96605" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12077" /db_xref="UniProtKB/Swiss-Prot:P96605" /translation="MAEPILHIEGLDKKIGSKQILKQISMDVMEGEIIGLLGPNGSGK TTLIRIIVGLLKQNSGSVTISGFQHDTEFEKAMEAVGAIVENPEFYPYLTGWENLKHF ANMHKKIADERLDEVVERVGLTSAIHDKVKTYSLGMRQRLGIAQAILHRPKLLILDEP TNGLDPAGMKDFRDHIKELAEMEGTAVLFATHLLREVEDLCDRVIIIQKGEIKAEVSL QGTDQTTEKAIIEVQPQEKALNWLTGNQYQAESQDGTIVVEVAKENIPELNRSLVGQD LNVFSITPYTQSLEDEFIKATTAHQEEGEELV*" /label="ydbJ CDS" gene 484475..485401 /gene="ydbJ" /locus_tag="BSU_04490" /old_locus_tag="BSU04490" /label="ydbJ gene" CDS 485421..486161 /gene="ydbK" /locus_tag="BSU_04500" /old_locus_tag="BSU04500" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12486040, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux ABC-transporter (permease subunit)" /protein_id="NP_388331.1" /db_xref="EnsemblGenomes-Gn:BSU04500" /db_xref="EnsemblGenomes-Tr:CAB12257" /db_xref="GOA:P96606" /db_xref="InterPro:IPR032688" /db_xref="SubtiList:BG12078" /db_xref="UniProtKB/Swiss-Prot:P96606" /translation="MKLFNRKVTLVSLILMAVFQFFMALIIKRIVISAGTDENFIGYL SYTPSLNILLQALTIVIAATIVSMEFDKKTIKFLLIRPVKRQKVFWSKLITVVMVSFY LYLAYYILALLFGLLFFGTSVTAESKTLLVNTLALIGSNWLEAVMMGLFGLLCSSLFR NSAVAVVVSFVVLYGASTLVQLMKLFENKWGSFLLFANTDFTQYRSGETALFSGMTPL FSIGILIIHAIFFIVVGWWCFCKRDVRV*" /label="ydbK CDS" gene 485421..486161 /gene="ydbK" /locus_tag="BSU_04500" /old_locus_tag="BSU04500" /label="ydbK gene" misc_feature 486220..486239 /Source="Nicolas_upshift_promotors" /id="U353" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.612387612387612" /psig="0.99000999000999" /xcortree=1624 /SigmaFactorBS="caaggaatgacatttttgtgaaaaagctcacgtaaatcaata tcatttgatatttTGGTTTATACTAAAGGTACTgacggaggtgtctcgattgaggaac t" /listShort="ydbL, S152, ydbM" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 486225 /Source="Nicolas_upshifts" /id="U353" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.612387612387612" /psig="0.99000999000999" /xcortree=1624 /SigmaFactorBS="caaggaatgacatttttgtgaaaaagctcacgtaaatcaata tcatttgatatttTGGTTTATACTAAAGGTACTgacggaggtgtctcgattgaggaac t" /listShort="ydbL, S152, ydbM" /GFF_Attribute="listLong" /label="upshifts" CDS 486256..486591 /gene="ydbL" /locus_tag="BSU_04510" /old_locus_tag="BSU04510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17928292; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative glyco-prenyl flippase subunit" /protein_id="NP_388332.1" /db_xref="EnsemblGenomes-Gn:BSU04510" /db_xref="EnsemblGenomes-Tr:CAB12258" /db_xref="GOA:P96607" /db_xref="SubtiList:BG12079" /db_xref="UniProtKB/Swiss-Prot:P96607" /translation="MRNFITALPIVLLLGFSFVSFMFQFEHLVYFRLALGLFSLVGLY MIYKMKTGIRYFIIYLYASWIVLAAVTAFEEPIFSSFFFGGLVMTMGYLTYMLIYLGM KQDRDANPV*" /label="ydbL CDS" gene 486256..486591 /gene="ydbL" /locus_tag="BSU_04510" /old_locus_tag="BSU04510" /label="ydbL gene" downshifts 486566 /Source="Nicolas_upshifts" /id="D214" /incds=0 /nref=2 /ntot=99 /MaxReadThrough="5.33473" /MaxDrop="5.39081" /score="25.8152101" /energy="-18.4" /TU="U352,U353" /idTUdmin="U352" /TUdmin="-1177" /isTUend="FALSE" /label="downshifts" S_feature 486611..486680 /Source="Nicolas_S_feature" /locus_tag="new_505044_505113" /HighExp="ferm, nit, S2, S0, Gly, M0t45, M0t90, Lbstat, M/G, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="0.99, 0.484" /TUlongSig="NA" /TUlongPSig="NA" /label="S152" promotor_-35 486646..486653 /Source="Nicolas_upshift_promotors" /id="U354" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.572427572427572" /psig="0.973026973026973" /xcortree=1741 /SigmaFactorBS="ttttctatactgggcaaaaggttaaCAGTTGCGgaaaaatgg caggAAATCTATAATACATATTAAatttatcggaattaaaactggggggctgccggat g" /listShort="ydbM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 486667..486686 /Source="Nicolas_upshift_promotors" /id="U354" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.572427572427572" /psig="0.973026973026973" /xcortree=1741 /SigmaFactorBS="ttttctatactgggcaaaaggttaaCAGTTGCGgaaaaatgg caggAAATCTATAATACATATTAAatttatcggaattaaaactggggggctgccggat g" /listShort="ydbM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 486681 /Source="Nicolas_upshifts" /id="U354" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.572427572427572" /psig="0.973026973026973" /xcortree=1741 /SigmaFactorBS="ttttctatactgggcaaaaggttaaCAGTTGCGgaaaaatgg caggAAATCTATAATACATATTAAatttatcggaattaaaactggggggctgccggat g" /listShort="ydbM" /GFF_Attribute="listLong" /label="upshifts" CDS 486719..487864 /gene="ydbM" /locus_tag="BSU_04520" /old_locus_tag="BSU04520" /EC_number="1.3.99.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12193636, 16513748, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyl-CoA dehydrogenase" /protein_id="NP_388333.1" /db_xref="EnsemblGenomes-Gn:BSU04520" /db_xref="EnsemblGenomes-Tr:CAB12259" /db_xref="GOA:P96608" /db_xref="InterPro:IPR006091" /db_xref="InterPro:IPR009100" /db_xref="InterPro:IPR013107" /db_xref="InterPro:IPR013786" /db_xref="InterPro:IPR036250" /db_xref="InterPro:IPR037069" /db_xref="SubtiList:BG12080" /db_xref="UniProtKB/Swiss-Prot:P96608" /translation="MSLFIQNDQQRQWMEKIGRIADEFQQTAAEDDEQGRFPAEKIQK LRDAGYTALTLPASHGGGGISVYDMLLFQERLARGDAPTALSIGWHLSVIGELGEGNS WDEDVFAFVAKEVQNGAVINRAATEAKTGSPTRGGRPGTHAVKKDGKWAVNGRKTFTT MSQALDYFLVTAWIEDKQTTGVFLIHKDDPGLSIEETWDMMAMRATGSHDLVLNEVML DENKLVELLQGPRGAKPNGWLLHIPAIYLGVAQAARDYAVQFASEYSPNSLNGPIKNV PAVQQRTGEMELELLNARHFLFHIAQLYDDPVRRPHLTSELGAAKHIVTNAALSVVDK AMRIVGAKSLERTNPLQRYYRDVRAGLHNPPMDDAVIHKLAAEAFES*" /label="ydbM CDS" gene 486719..487864 /gene="ydbM" /locus_tag="BSU_04520" /old_locus_tag="BSU04520" /label="ydbM gene" downshifts 487846 /Source="Nicolas_upshifts" /id="D215" /incds=0 /nref=13 /ntot=123 /MaxReadThrough="2.90782" /MaxDrop="4.20573" /score="9.48525091" /energy="-7" /TU="NA" /idTUdmin="U353" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" CDS complement(487889..488068) /gene="fbpB" /locus_tag="BSU_04530" /old_locus_tag="BSU04530" /experiment="publication(s) with functional evidences, PMID:12354229, 16428414, 18697947, 22427629" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 16428414, 18697947, 22427629; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of iron homeostasis" /protein_id="NP_388334.1" /db_xref="EnsemblGenomes-Gn:BSU04530" /db_xref="EnsemblGenomes-Tr:CAB12260" /db_xref="GOA:P96609" /db_xref="InterPro:IPR025004" /db_xref="SubtiList:BG12081" /db_xref="UniProtKB/Swiss-Prot:P96609" /translation="MNTNMSGGRRSMPKRKVKTYQQLIQENKEAIMGNPKLMNVIYDR IDRKHQKNLQEQNNT*" /label="fbpB CDS" gene complement(487889..488068) /gene="fbpB" /locus_tag="BSU_04530" /old_locus_tag="BSU04530" /label="fbpB gene" downshifts complement(487907) /Source="Nicolas_upshifts" /id="D216" /incds=0 /nref=158 /ntot=207 /MaxReadThrough="2.35872" /MaxDrop="6.38199" /score="26.3317207" /energy="-7" /TU="NA" /idTUdmin="U355" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(488022..488186) /gene="fbpA" /locus_tag="BSU_04536" /old_locus_tag="BSU04536" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:18697947" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18697947; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of iron homeostasis" /protein_id="YP_009513944.1" /db_xref="EnsemblGenomes-Gn:BSU04536" /db_xref="EnsemblGenomes-Tr:CCQ48594" /db_xref="InterPro:IPR025072" /db_xref="UniProtKB/TrEMBL:L8ECQ9" /translation="MTPQSAEIRKKQLIHLLIQNGIYKKSKRHLYELSLTELESEYKH VRRAPEHAEA*" /label="fbpA CDS" gene complement(488022..488186) /gene="fbpA" /locus_tag="BSU_04536" /old_locus_tag="BSU04536" /label="fbpA gene" S_feature complement(488069..488237) /Source="Nicolas_S_feature" /locus_tag="new_506502_506670_c" /HighExp="B60, nit, B36, Lbexp, GM 15, GM 10, dia0, S2, GM 25, BI" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99141199999999996" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S153" promotor_-10 complement(488229..488248) /Source="Nicolas_upshift_promotors" /id="U355" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2111 /SigmaFactorBS="taaattggccaagaataggactcttttcaTCTTTACAggcta ttgcggacaTTGTATACTGAAGTTAATTGataatgattatcaatatcgtttgattgga g" /listShort="S153, ydbN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(488239) /Source="Nicolas_upshifts" /id="U355" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2111 /SigmaFactorBS="taaattggccaagaataggactcttttcaTCTTTACAggcta ttgcggacaTTGTATACTGAAGTTAATTGataatgattatcaatatcgtttgattgga g" /listShort="S153, ydbN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(488263..488270) /Source="Nicolas_upshift_promotors" /id="U355" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2111 /SigmaFactorBS="taaattggccaagaataggactcttttcaTCTTTACAggcta ttgcggacaTTGTATACTGAAGTTAATTGataatgattatcaatatcgtttgattgga g" /listShort="S153, ydbN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 488378..488383 /Source="Nicolas_upshift_promotors" /id="U356" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.933066933066933" /psig="0.933066933066933" /xcortree=1191 /SigmaFactorBS="tgctgtcgaaatattccgcttcattgaacgcacccTGCTATt tttcatgttttgaaCCATACTATGTAATAGAATggaggctggtattcaatggagcgga c" /listShort="ydbO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 488399..488417 /Source="Nicolas_upshift_promotors" /id="U356" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.933066933066933" /psig="0.933066933066933" /xcortree=1191 /SigmaFactorBS="tgctgtcgaaatattccgcttcattgaacgcacccTGCTATt tttcatgttttgaaCCATACTATGTAATAGAATggaggctggtattcaatggagcgga c" /listShort="ydbO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 488403 /Source="Nicolas_upshifts" /id="U356" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.933066933066933" /psig="0.933066933066933" /xcortree=1191 /SigmaFactorBS="tgctgtcgaaatattccgcttcattgaacgcacccTGCTATt tttcatgttttgaaCCATACTATGTAATAGAATggaggctggtattcaatggagcgga c" /listShort="ydbO" /GFF_Attribute="listLong" /label="upshifts" CDS 488433..489305 /gene="ydbO" /locus_tag="BSU_04540" /old_locus_tag="BSU04540" /function="16.8: Protect" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative cation efflux system" /protein_id="NP_388335.1" /db_xref="EnsemblGenomes-Gn:BSU04540" /db_xref="EnsemblGenomes-Tr:CAB12261" /db_xref="GOA:P96610" /db_xref="InterPro:IPR002524" /db_xref="InterPro:IPR027469" /db_xref="InterPro:IPR027470" /db_xref="InterPro:IPR036837" /db_xref="SubtiList:BG12082" /db_xref="UniProtKB/Swiss-Prot:P96610" /translation="MERTENLKKGEKGALLNIFAYVILAVVKLVIGILYHSEALRADG LNNGTDIVASVAVLIGLRISQRPADSDHPYGHYRAETISSLVASFIMMAVGIEVLIGG GKAIAGGTTETPNLIAAWTALGSAVFMYGIYLYNKRLAASIKSSALMAAAKDSRSDAF VSAGAFIGVFSSQLKLPWVDPVTAFIIGIIICKTAWDIFKDASHSLTDGFHLKDLEPY KQTVGRIENVHRLKDVKARYLGSTVHIEMVITVDPKLTVEEGHGVADEVEDKIKHEHD VTHVHVHVEPDDIK*" /label="ydbO CDS" gene 488433..489305 /gene="ydbO" /locus_tag="BSU_04540" /old_locus_tag="BSU04540" /label="ydbO gene" promotor_-35 488669..488678 /Source="Nicolas_upshift_promotors" /id="U357" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1650 /SigmaFactorBS="gctgacagcgatcatccatacggccattatcgggcTGAAACA ATTtcgtctcttgttGCGTCTTTTATTATGAtggcagtcggcattgaagtgttaatcg g" /listShort="S155, S156, ddl, murF, S157, S158, cshA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 488691..488706 /Source="Nicolas_upshift_promotors" /id="U357" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1650 /SigmaFactorBS="gctgacagcgatcatccatacggccattatcgggcTGAAACA ATTtcgtctcttgttGCGTCTTTTATTATGAtggcagtcggcattgaagtgttaatcg g" /listShort="S155, S156, ddl, murF, S157, S158, cshA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 488694 /Source="Nicolas_upshifts" /id="U357" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1650 /SigmaFactorBS="gctgacagcgatcatccatacggccattatcgggcTGAAACA ATTtcgtctcttgttGCGTCTTTTATTATGAtggcagtcggcattgaagtgttaatcg g" /listShort="S155, S156, ddl, murF, S157, S158, cshA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(489250..489319) /Source="Nicolas_S_feature" /locus_tag="new_507683_507752_c" /HighExp="LPhT, dia15, dia5, Diami, Etha, Lbtran, LBGtran, LBGstat, Mt0, M0t45" /AntisenseName="ydbO" /AntisenseCor="0.18463882527998399" /AntisenseRegPval="-2.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S154" downshifts complement(489293) /Source="Nicolas_upshifts" /id="D217" /incds=0 /nref=145 /ntot=242 /MaxReadThrough="3.07579" /MaxDrop="6.00116" /score="9.69023537" /energy="-12.3" /TU="U359" /idTUdmin="U359" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" S_feature 489306..489655 /Source="Nicolas_S_feature" /locus_tag="new_507739_508088" /HighExp="Salt, Paraq, G135, ferm, Oxctl, T-0.40H, G150, Lbexp, T3.0H, T2.30H" /AntisenseName="ydbP" /AntisenseCor="-0.27800721625230801" /AntisenseRegPval="-5.4" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S155" CDS complement(489320..489640) /gene="ydbP" /locus_tag="BSU_04550" /old_locus_tag="BSU04550" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10482513; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative thioredoxin or thiol-disulfide isomerase" /protein_id="NP_388336.1" /db_xref="EnsemblGenomes-Gn:BSU04550" /db_xref="EnsemblGenomes-Tr:CAB12262" /db_xref="GOA:P96611" /db_xref="InterPro:IPR005746" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG12083" /db_xref="UniProtKB/Swiss-Prot:P96611" /translation="MKKITTNEQFNELIQSDKEIIVKFYADWCPDCTRMNMFIGDILE EYNQNDWYELNKDELPDLAEKYQVMGIPSLLIFKNGEKTAHLHSANAKTPEEVTEFLS EHIS*" /label="ydbP CDS" gene complement(489320..489640) /gene="ydbP" /locus_tag="BSU_04550" /old_locus_tag="BSU04550" /label="ydbP gene" promotor_-35 489636..489640 /Source="Nicolas_upshift_promotors" /id="U358" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.65034965034965" /psig="0.298701298701299" /xcortree=1554 /SigmaFactorBS="tgaatcagttcattaaattgttcgtttgttgtgatttttTTC ATatgtcacaTCTCCTTTTCAATGCcattttaatataaaataaaaaggaattacatac a" /listShort="S156, ddl, murF, S157, S158, cshA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 489649..489663 /Source="Nicolas_upshift_promotors" /id="U358" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.65034965034965" /psig="0.298701298701299" /xcortree=1554 /SigmaFactorBS="tgaatcagttcattaaattgttcgtttgttgtgatttttTTC ATatgtcacaTCTCCTTTTCAATGCcattttaatataaaataaaaaggaattacatac a" /listShort="S156, ddl, murF, S157, S158, cshA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 489657..489814 /Source="Nicolas_S_feature" /locus_tag="new_508090_508247" /HighExp="Lbexp, dia0, LBGexp, H2O2, Paraq, Oxctl, G180, Salt, M0t45, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigWXY" /TUshortPSig="0.299, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S156" upshifts 489657 /Source="Nicolas_upshifts" /id="U358" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.65034965034965" /psig="0.298701298701299" /xcortree=1554 /SigmaFactorBS="tgaatcagttcattaaattgttcgtttgttgtgatttttTTC ATatgtcacaTCTCCTTTTCAATGCcattttaatataaaataaaaaggaattacatac a" /listShort="S156, ddl, murF, S157, S158, cshA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(489661..489680) /Source="Nicolas_upshift_promotors" /id="U359" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=2021 /SigmaFactorBS="gatctaattatttttgggcatgctgatgttgaatgCATTTGT AtgtaattccttttTATTTTATATTAAAATGGCAttgaaaaggagatgtgacatatga a" /listShort="ydbP, S154" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(489676) /Source="Nicolas_upshifts" /id="U359" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=2021 /SigmaFactorBS="gatctaattatttttgggcatgctgatgttgaatgCATTTGT AtgtaattccttttTATTTTATATTAAAATGGCAttgaaaaggagatgtgacatatga a" /listShort="ydbP, S154" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(489694..489701) /Source="Nicolas_upshift_promotors" /id="U359" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=2021 /SigmaFactorBS="gatctaattatttttgggcatgctgatgttgaatgCATTTGT AtgtaattccttttTATTTTATATTAAAATGGCAttgaaaaggagatgtgacatatga a" /listShort="ydbP, S154" /GFF_Attribute="listLong" /label="promotor_-35" CDS 489815..490879 /gene="ddlA" /locus_tag="BSU_04560" /old_locus_tag="BSU04560" /EC_number="6.3.2.4" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8662022, 12682299, 22407814; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-alanyl-D-alanine ligase A" /protein_id="NP_388337.1" /db_xref="EnsemblGenomes-Gn:BSU04560" /db_xref="EnsemblGenomes-Tr:CAB12263" /db_xref="GOA:P96612" /db_xref="InterPro:IPR000291" /db_xref="InterPro:IPR005905" /db_xref="InterPro:IPR011095" /db_xref="InterPro:IPR011127" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="SubtiList:BG11932" /db_xref="UniProtKB/Swiss-Prot:P96612" /translation="MYGGKSAEHNVSLQTALAVIKALNTEKFDIHPIYITEKGEWVRG ARLTEPVSNVKMLQFEQGGSAFSPAALNQEMFPQEASQQNEAIDVVFPLLHGPNGEDG TIQGMLELLNIPYVGNGVLASSAGMDKVVMKHLFAQVGLAQAKYAAFLKKDWTRSPKE SCEEVEQELGYPCFVKPANLGSSVGISKCRNREELQKAFELAFQYDRKVVVEEGINGR EIEIGVLGNDDPKCSVVGEIAPKTDFYDYKAKYEDGDTDLMIPAIVTDEEYATISDMA IKAFKAIDGSGLVRADFFLTADGEVLINEVNTMPGFTPFSMFPLLWKEAGVEYADLIE QLVELAKERHAEKQLIKHTF*" /label="ddlA CDS" gene 489815..490879 /gene="ddlA" /locus_tag="BSU_04560" /old_locus_tag="BSU04560" /label="ddlA gene" downshifts 490867 /Source="Nicolas_upshifts" /id="D218" /incds=0 /nref=1 /ntot=59 /MaxReadThrough="5.68418" /MaxDrop="2.53103" /score="3.92144467" /energy="-9.6" /TU="U357,U358" /idTUdmin="U356" /TUdmin=2310 /isTUend="FALSE" /label="downshifts" CDS 490951..492324 /gene="murF" /locus_tag="BSU_04570" /old_locus_tag="BSU04570" /EC_number="6.3.2.10" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 17714441; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate-D-alanyl-D-alanine ligase" /protein_id="NP_388338.1" /db_xref="EnsemblGenomes-Gn:BSU04570" /db_xref="EnsemblGenomes-Tr:CAB12264" /db_xref="GOA:P96613" /db_xref="InterPro:IPR000713" /db_xref="InterPro:IPR004101" /db_xref="InterPro:IPR005863" /db_xref="InterPro:IPR013221" /db_xref="InterPro:IPR035911" /db_xref="InterPro:IPR036565" /db_xref="InterPro:IPR036615" /db_xref="SubtiList:BG12084" /db_xref="UniProtKB/Swiss-Prot:P96613" /translation="MIKRTVKNIAEMVKGTLANPQYEQTVIHGVATDTRKLEQHQLFI PLKGERFDGHSFVEQAFEAGVAAVLWDRSVPNPPENHAVILVDDTLTALQQLAKAYLQ ELGTRVIGVTGSNGKTTTKDMIHAVLGTQYRVHKTGGNFNNHIGLPLTVLAMPENTEI AVLEMGMSAKGEIDLLSRLANPDAAVITNIGESHMQDLGSREGIAEAKLEIINGLKED GVLIYIGDEPLLQNAYSCQTKTYGTGTHNDYQLQDVSQSEEGTHFTIKGIENTFFIPI LGKHNVMNAMAAIAAGAYFGIAPEDAAKGLSGLKVTGMRLELIKTDSGLSIINDAYNA SPTSMKAAIQLTESLEGYGKKMLVLGDMLELGDLEETFHKECGAVISPDKIDRVFTYG KLGAFIAEGALKHFEKDRVSHYTEKKDLLQAVKENASKGDLILFKASRGMKLEEIVKD LIESPLS*" /label="murF CDS" gene 490951..492324 /gene="murF" /locus_tag="BSU_04570" /old_locus_tag="BSU04570" /label="murF gene" promotor_-35 492355..492361 /Source="Nicolas_upshift_promotors" /id="U360" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=849 /SigmaFactorBS="gaaaatattttgcgaaaaaacgcatattgcATCATAAaataa cctgatatGCAAACACTAATgtatgccggccgaaaattatgtatatctggccggctgc g" /listShort="S157, S158, cshA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 492375..492386 /Source="Nicolas_upshift_promotors" /id="U360" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=849 /SigmaFactorBS="gaaaatattttgcgaaaaaacgcatattgcATCATAAaataa cctgatatGCAAACACTAATgtatgccggccgaaaattatgtatatctggccggctgc g" /listShort="S157, S158, cshA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 492385 /Source="Nicolas_upshifts" /id="U360" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=849 /SigmaFactorBS="gaaaatattttgcgaaaaaacgcatattgcATCATAAaataa cctgatatGCAAACACTAATgtatgccggccgaaaattatgtatatctggccggctgc g" /listShort="S157, S158, cshA" /GFF_Attribute="listLong" /label="upshifts" misc_feature 492428..492447 /Source="Nicolas_upshift_promotors" /id="U361" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.958041958041958" /psig=1 /xcortree=2138 /SigmaFactorBS="tgatatgcaaacactaatgtatgccggccgaaaattatgtat atctggccggctgcggcTATGATACAATATATATAGGttatttcgcgatacgaacata t" /listShort="S157, S158, cshA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 492429..492603 /Source="Nicolas_S_feature" /locus_tag="new_510862_511036" /HighExp="Cold, ferm, nit, G135, S5, LBGexp, G150, S8, S7, BI" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.76694499999999999" /TUshortSig="SigA, SigGF, Sig-, SigWXY" /TUshortPSig="1, 1, 0.299, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S157" upshifts 492429 /Source="Nicolas_upshifts" /id="U361" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.958041958041958" /psig=1 /xcortree=2138 /SigmaFactorBS="tgatatgcaaacactaatgtatgccggccgaaaattatgtat atctggccggctgcggcTATGATACAATATATATAGGttatttcgcgatacgaacata t" /listShort="S157, S158, cshA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 492571..492578 /Source="Nicolas_upshift_promotors" /id="U362" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=1884 /SigmaFactorBS="tcgagatgccgatctgcttctcatctTATTGAAAaacaaata gtgtaaTGGTAAGATAAAACTTAAAGtaattcgggctttgtatacggatggatcctgt c" /listShort="S158, cshA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 492593..492612 /Source="Nicolas_upshift_promotors" /id="U362" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=1884 /SigmaFactorBS="tcgagatgccgatctgcttctcatctTATTGAAAaacaaata gtgtaaTGGTAAGATAAAACTTAAAGtaattcgggctttgtatacggatggatcctgt c" /listShort="S158, cshA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 492605..492672 /Source="Nicolas_S_feature" /locus_tag="new_511038_511105" /HighExp="Cold, G150, T-3.40H, HPh, Salt, LPh, G180, G135, Oxctl, T-5.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigGF, Sig-, SigWXY" /TUshortPSig="1, 1, 1, 0.299, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S158" upshifts 492605 /Source="Nicolas_upshifts" /id="U362" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=1884 /SigmaFactorBS="tcgagatgccgatctgcttctcatctTATTGAAAaacaaata gtgtaaTGGTAAGATAAAACTTAAAGtaattcgggctttgtatacggatggatcctgt c" /listShort="S158, cshA" /GFF_Attribute="listLong" /label="upshifts" CDS 492724..494208 /gene="cshA" /locus_tag="BSU_04580" /old_locus_tag="BSU04580" /EC_number="3.6.1.-" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16352840, 27965645" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16352840, 27965645; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent RNA helicase; cold shock" /protein_id="NP_388339.2" /db_xref="EnsemblGenomes-Gn:BSU04580" /db_xref="EnsemblGenomes-Tr:CAB12265" /db_xref="GOA:P96614" /db_xref="InterPro:IPR000629" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR014014" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030880" /db_xref="SubtiList:BG12085" /db_xref="UniProtKB/Swiss-Prot:P96614" /translation="MTITFQDFNLSSDLMKAINRMGFEEATPIQAQTIPLGLSNKDVI GQAQTGTGKTAAFGIPLVEKINPESPNIQAIVIAPTRELAIQVSEELYKIGQDKRAKV LPIYGGQDIGRQIRALKKNPNIIVGTPGRLLDHINRRTIRLNNVNTVVMDEADEMLNM GFIDDIESILSNVPSEHQTLLFSATMPAPIKRIAERFMTEPEHVKVKAKEMTVSNIQQ FYLEVQERKKFDTLTRLLDIQSPELAIVFGRTKRRVDELAEALNLRGYAAEGIHGDLT QAKRMVALRKFKEGAIEVLVATDVAARGLDISGVTHVYNFDVPQDPESYVHRIGRTGR AGKTGMAMTFITPREKSMLRAIEQTTKRKMDRMKEPTLDEALEGQQQVTVERLRTTIS ENNLNFYMTAAAELLEDHDAVTVVAAAIKMATKEPDDTPVRLTDEAPMVSKRYKNQRS SKRRDGQGGGYRGGKGKSNNRSSYDKKRSNDRRSSGDRRQKKSY*" /label="cshA CDS" gene 492724..494208 /gene="cshA" /locus_tag="BSU_04580" /old_locus_tag="BSU04580" /label="cshA gene" downshifts 494201 /Source="Nicolas_upshifts" /id="D219" /incds=0 /nref=309 /ntot=313 /MaxReadThrough="1.91428" /MaxDrop="8.13079" /score="26.104757" /energy="-13.1" /TU="NA" /idTUdmin="U358" /TUdmin="-10" /isTUend="TRUE" /label="downshifts" S_feature 494321..494380 /Source="Nicolas_S_feature" /locus_tag="new_512754_512813" /HighExp="Etha, LBGexp, G180, Cold, Lbtran, dia0, G150, BMM, UNK1, MG-0.1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S159" promotor_-35 494321..494330 /Source="Nicolas_upshift_promotors" /id="U363" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1673 /SigmaFactorBS="tttgttattcagcaaactttcagctgacggaagccatttttc tctgtatgcttaagaaTGAAACCTTTctgtaaaagagACGTATAAATAACGACgaaaa a" /listShort="S159, ydbS, ydbT, S160, S161, acpS, S162, ydcC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 494323 /Source="Nicolas_upshifts" /id="U363" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1673 /SigmaFactorBS="tttgttattcagcaaactttcagctgacggaagccatttttc tctgtatgcttaagaaTGAAACCTTTctgtaaaagagACGTATAAATAACGACgaaaa a" /listShort="S159, ydbS, ydbT, S160, S161, acpS, S162, ydcC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 494342..494357 /Source="Nicolas_upshift_promotors" /id="U363" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1673 /SigmaFactorBS="tttgttattcagcaaactttcagctgacggaagccatttttc tctgtatgcttaagaaTGAAACCTTTctgtaaaagagACGTATAAATAACGACgaaaa a" /listShort="S159, ydbS, ydbT, S160, S161, acpS, S162, ydcC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 494381..494860 /gene="ydbS" /locus_tag="BSU_04590" /old_locus_tag="BSU04590" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16629676" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16629676; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="resistance to heterologous antibiotics" /protein_id="NP_388340.1" /db_xref="EnsemblGenomes-Gn:BSU04590" /db_xref="EnsemblGenomes-Tr:CAB12266" /db_xref="GOA:P96615" /db_xref="InterPro:IPR005182" /db_xref="SubtiList:BG12086" /db_xref="UniProtKB/Swiss-Prot:P96615" /translation="MREQPKNQISPDGLKVWRLQEIIISAVCLLIVIAVAVLSYYFHW PYWISGVLGAVWLLGSIVTVFIIPKVRHKVWRYEVHEHEIDIQSGIFVVTRVIVPMVR VQHVDTSQGPLLKKYNLATVKISTAATVHSIPALEMEEADRLRDSISRLARVTDDDV* " /label="ydbS CDS" gene 494381..494860 /gene="ydbS" /locus_tag="BSU_04590" /old_locus_tag="BSU04590" /label="ydbS gene" CDS 494850..496331 /gene="ydbT" /locus_tag="BSU_04600" /old_locus_tag="BSU04600" /experiment="publication(s) with functional evidences, PMID:16629676" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16629676; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="resistance to heterologous antibiotics" /protein_id="NP_388341.1" /db_xref="EnsemblGenomes-Gn:BSU04600" /db_xref="EnsemblGenomes-Tr:CAB12267" /db_xref="GOA:P96616" /db_xref="InterPro:IPR005182" /db_xref="InterPro:IPR014529" /db_xref="SubtiList:BG12087" /db_xref="UniProtKB/Swiss-Prot:P96616" /translation="MMSEPKRLHPVAVILNLCHTIIQTIKNIILPFFFVYIVNSNHTV RFYGAIALGVLFIWLVAASIIKWRRFTYRIEDDEFRIEEGLFVTKKRYISIDRIQTMN TSAGLVQQIFKLVKLQIETAGGGKEAEAVLSAISVEEAERIKEAVFKKKAQRRENELD EERLEAEEELDPSVEVQEHYRMNAKELLMAASTSGGIGVIISAVFALISQLDEVLPMD WLFDKFSFLQHASIGIYAVLIFIGLFIAWIFSIAGMMFRYANFQIIKKEQELVISRGI IEKHQVTIPLRKIQAIKIKENIIRQLFGFVTVSIVSAGGGDREKEEGALTILFPMIHK KKLPHMLRTFTPEYTLEENCRRLPRRALKRYLFRSVIFSLFLIIPLCIFFQPWGYLSV ILLPIELLFGYLAYKEAAWTINGDRLQLTSRFIGRTTAIVLKKRMQVCKFSQSYFQKK GRLYTISTSVKSSSHMEELTVRDVGEEDAAFILKWYSYEKADG*" /label="ydbT CDS" gene 494850..496331 /gene="ydbT" /locus_tag="BSU_04600" /old_locus_tag="BSU04600" /label="ydbT gene" downshifts 496301 /Source="Nicolas_upshifts" /id="D220" /incds=0 /nref=6 /ntot=162 /MaxReadThrough="4.90913" /MaxDrop="3.0931" /score="48.2239319" /energy="-17.1" /TU="U363" /idTUdmin="U364" /TUdmin="-638" /isTUend="FALSE" /label="downshifts" S_feature 496346..496673 /Source="Nicolas_S_feature" /locus_tag="new_514779_515106" /HighExp="Salt, T0.30H, G135, T1.0H, T1.30H, G150, G180, Oxctl, T-0.40H, aero" /AntisenseName="ydcA" /AntisenseCor="-0.25636523135066602" /AntisenseRegPval="-4.7" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S160" downshifts complement(496355) /Source="Nicolas_upshifts" /id="D221" /incds=0 /nref=1 /ntot=66 /MaxReadThrough="0.258529999999999" /MaxDrop="3.15455" /score="-3.74867023" /energy="-8.8" /TU="NA" /idTUdmin="U365" /TUdmin=220 /isTUend="FALSE" /label="downshifts" CDS complement(496583..497182) /gene="ydcA" /locus_tag="BSU_04610" /old_locus_tag="BSU04610" /EC_number="3.4.21.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15616571, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative rhomboid protease" /protein_id="NP_388342.1" /db_xref="EnsemblGenomes-Gn:BSU04610" /db_xref="EnsemblGenomes-Tr:CAB12268" /db_xref="GOA:P96617" /db_xref="InterPro:IPR022764" /db_xref="InterPro:IPR035952" /db_xref="SubtiList:BG12088" /db_xref="UniProtKB/Swiss-Prot:P96617" /translation="MFIRTENFQTFIRLYPVVTFILALQAVLWLFFSLPAHSVVLWRD TVTGYNLGVANGEWWRLITPILLHAGFTHLLFNSMSIFLFAPALERMLGKARFLLVYA GSGIIGNIGTYVTEPLDYVHVGASGAIFGLFGVYLFMVLFRNELIGQEHSKMIITLLA FAVLMSFINSNINMMAHLFGLCGGFLLSFLCVQKKERRY*" /label="ydcA CDS" gene complement(496583..497182) /gene="ydcA" /locus_tag="BSU_04610" /old_locus_tag="BSU04610" /label="ydcA gene" promotor_-35 496643..496648 /Source="Nicolas_upshift_promotors" /id="U364" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2751 /SigmaFactorBS="aaaacgaaagaagaaacccgccgcatagTCCAAAcaaatggg ccatCATGTTAATATTGGAGTTGAtaaacgacatgagaacggcaaatgcgagcagtgt g" /listShort="S161" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 496661..496680 /Source="Nicolas_upshift_promotors" /id="U364" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2751 /SigmaFactorBS="aaaacgaaagaagaaacccgccgcatagTCCAAAcaaatggg ccatCATGTTAATATTGGAGTTGAtaaacgacatgagaacggcaaatgcgagcagtgt g" /listShort="S161" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 496675..497276 /Source="Nicolas_S_feature" /locus_tag="new_515108_515709" /HighExp="Salt, G135, G150, T0.30H, G180, T1.0H, T1.30H, H2O2, Paraq, Oxctl" /AntisenseName="ydcA" /AntisenseCor="-0.11975373672841701" /AntisenseRegPval="-1.3" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigWXY" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S161" upshifts 496675 /Source="Nicolas_upshifts" /id="U364" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2751 /SigmaFactorBS="aaaacgaaagaagaaacccgccgcatagTCCAAAcaaatggg ccatCATGTTAATATTGGAGTTGAtaaacgacatgagaacggcaaatgcgagcagtgt g" /listShort="S161" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(497206..497225) /Source="Nicolas_upshift_promotors" /id="U365" /multdbtbs="SigE" /comp="M4" /sig="SigA" /pcomp="0.879120879120879" /psig="0.907092907092907" /xcortree=1402 /SigmaFactorBS="tgtatgataacctcctttgcgtacgtactatttaaatggttt gtctcataaaCGTGTTACTATAGATATACCaaaatgaagaaaaggggctcggaatgtt t" /listShort="ydcA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(497217) /Source="Nicolas_upshifts" /id="U365" /multdbtbs="SigE" /comp="M4" /sig="SigA" /pcomp="0.879120879120879" /psig="0.907092907092907" /xcortree=1402 /SigmaFactorBS="tgtatgataacctcctttgcgtacgtactatttaaatggttt gtctcataaaCGTGTTACTATAGATATACCaaaatgaagaaaaggggctcggaatgtt t" /listShort="ydcA" /GFF_Attribute="listLong" /label="upshifts" CDS 497277..497642 /gene="acpS" /locus_tag="BSU_04620" /old_locus_tag="BSU04620" /EC_number="2.7.8.7" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11489886, 11525165, 11867633, 12682299, 12926246, 15955059, 16597923; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="holo-acyl carrier protein synthase (phosphopantetheinyl transferase)" /protein_id="NP_388343.1" /db_xref="EnsemblGenomes-Gn:BSU04620" /db_xref="EnsemblGenomes-Tr:CAB12269" /db_xref="GOA:P96618" /db_xref="InterPro:IPR002582" /db_xref="InterPro:IPR004568" /db_xref="InterPro:IPR008278" /db_xref="InterPro:IPR037143" /db_xref="PDB:1F7L" /db_xref="PDB:1F7T" /db_xref="PDB:1F80" /db_xref="SubtiList:BG12089" /db_xref="UniProtKB/Swiss-Prot:P96618" /translation="MIYGIGLDITELKRIASMAGRQKRFAERILTRSELDQYYELSEK RKNEFLAGRFAAKEAFSKAFGTGIGRQLSFQDIEIRKDQNGKPYIICTKLSQAAVHVS ITHTKEYAAAQVVIERLSS*" /label="acpS CDS" gene 497277..497642 /gene="acpS" /locus_tag="BSU_04620" /old_locus_tag="BSU04620" /label="acpS gene" promotor_-35 497645..497650 /Source="Nicolas_upshift_promotors" /id="U366" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=976 /SigmaFactorBS="tgccgcgcaggttgtgattgaaaggttgtcaagctagtcTGC ATAttagggaaaccccacTCATATATTTGATAGTGCAttaagggagacaagttgtttg a" /listShort="S162, ydcC, alrA" /listLong="endB, ndoA" /label="promotor_-35" S_feature 497666..497807 /Source="Nicolas_S_feature" /locus_tag="new_516099_516240" /HighExp="S3, S4, BT, LoTm, S5, T5.0H, M9-stat, S7, T4.0H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigWXY" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S162" promotor_-10 497666..497684 /Source="Nicolas_upshift_promotors" /id="U366" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=976 /SigmaFactorBS="tgccgcgcaggttgtgattgaaaggttgtcaagctagtcTGC ATAttagggaaaccccacTCATATATTTGATAGTGCAttaagggagacaagttgtttg a" /listShort="S162, ydcC, alrA" /listLong="endB, ndoA" /label="promotor_-10" upshifts 497666 /Source="Nicolas_upshifts" /id="U366" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=976 /SigmaFactorBS="tgccgcgcaggttgtgattgaaaggttgtcaagctagtcTGC ATAttagggaaaccccacTCATATATTTGATAGTGCAttaagggagacaagttgtttg a" /listShort="S162, ydcC, alrA" /listLong="endB, ndoA" /label="upshifts" CDS 497808..498824 /gene="ydcC" /locus_tag="BSU_04630" /old_locus_tag="BSU04630" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14523133; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_388344.2" /db_xref="EnsemblGenomes-Gn:BSU04630" /db_xref="EnsemblGenomes-Tr:CAB12270" /db_xref="GOA:P96619" /db_xref="InterPro:IPR029046" /db_xref="SubtiList:BG12090" /db_xref="UniProtKB/Swiss-Prot:P96619" /translation="MKKVRKSFVLLLTGLLAVLILSACGQKTQQDIVAGLDEKAKEYT SYKAKAKMTIETGSEPQVYNVEIWHKKPSLYRVYLENPKKDQNQVILRNENGVFVLTP SLNKSFRFQSDWPNNSSQVYLFESLVKDVQNDSDAVFTAKEKKYVFETKTNYQHNKML PTQEITFNKKDMSPSSVKVMDTDRKVMVKVEFSSFEFNKQFDKESFDEKKNMTLSQMD VATSAKPSDTFAVKTPLELPLGVKLLEEKDISTEDGKRIIMTYGGEKSFTLIQEKAQI AKASSSVTLNGEPVNLGYTIGALSDASLSWTYDGVDYLLSSKDLSKEEMVTVAKSMQG QSSK*" /label="ydcC CDS" gene 497808..498824 /gene="ydcC" /locus_tag="BSU_04630" /old_locus_tag="BSU04630" /label="ydcC gene" downshifts 498809 /Source="Nicolas_upshifts" /id="D222" /incds=0 /nref=193 /ntot=256 /MaxReadThrough="3.39815" /MaxDrop="6.13946" /score="22.0391647" /energy="-9.5" /TU="U366" /idTUdmin="U363" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 498869..498876 /Source="Nicolas_upshift_promotors" /id="U367" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.652347652347652" /psig=1 /xcortree=1877 /SigmaFactorBS="aaacatgatttggcctttttttcgttagacatCGTTTCCCtt tagcctttaatTTTAGTATGATATGTAAATGatattgaataaaagctaggaagtgtcg t" /listShort="alrA, endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 498890..498909 /Source="Nicolas_upshift_promotors" /id="U367" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.652347652347652" /psig=1 /xcortree=1877 /SigmaFactorBS="aaacatgatttggcctttttttcgttagacatCGTTTCCCtt tagcctttaatTTTAGTATGATATGTAAATGatattgaataaaagctaggaagtgtcg t" /listShort="alrA, endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 498897 /Source="Nicolas_upshifts" /id="U367" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.652347652347652" /psig=1 /xcortree=1877 /SigmaFactorBS="aaacatgatttggcctttttttcgttagacatCGTTTCCCtt tagcctttaatTTTAGTATGATATGTAAATGatattgaataaaagctaggaagtgtcg t" /listShort="alrA, endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="upshifts" CDS 498939..500108 /gene="alrA" /locus_tag="BSU_04640" /old_locus_tag="BSU04640" /EC_number="5.1.1.1" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 2835089, 12682299, 15043879, 18399999, 25227915; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-alanine racemase" /protein_id="NP_388345.1" /db_xref="EnsemblGenomes-Gn:BSU04640" /db_xref="EnsemblGenomes-Tr:CAB12271" /db_xref="GOA:P10725" /db_xref="InterPro:IPR000821" /db_xref="InterPro:IPR001608" /db_xref="InterPro:IPR009006" /db_xref="InterPro:IPR011079" /db_xref="InterPro:IPR020622" /db_xref="InterPro:IPR029066" /db_xref="SubtiList:BG10950" /db_xref="UniProtKB/Swiss-Prot:P10725" /translation="MSTKPFYRDTWAEIDLSAIKENVSNMKKHIGEHVHLMAVVKANA YGHGDAETAKAALDAGASCLAVAILDEAISLRKKGLKAPILVLGAVPPEYVAIAAEYD VTLTGYSVEWLQEAARHTKKGSLHFHLKVDTGMNRLGVKTEEEVQNVMAILDRNPRLK CKGVFTHFATADEKERGYFLMQFERFKELIAPLPLKNLMVHCANSAAGLRLKKGFFNA VRFGIGMYGLRPSADMSDEIPFQLRPAFTLHSTLSHVKLIRKGESVSYGAEYTAEKDT WIGTVPVGYADGWLRKLKGTDILVKGKRLKIAGRICMDQFMVELDQEYPPGTKVTLIG RQGDEYISMDEIAGRLETINYEVACTISSRVPRMFLENGSIMEVRNPLLQVNISN*" /label="alrA CDS" gene 498939..500108 /gene="alrA" /locus_tag="BSU_04640" /old_locus_tag="BSU04640" /label="alrA gene" promotor_-35 500037..500042 /Source="Nicolas_upshift_promotors" /id="U368" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.93906093906094" /psig="0.93906093906094" /xcortree=1177 /SigmaFactorBS="tgaggtggcctgtacaataagttcccgtgttcccCGTATGtt tttggaaaatggGAGTATAATGGAAGTAAGAaatcctttattgcaggtaaatataagc a" /listShort="endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 500057..500075 /Source="Nicolas_upshift_promotors" /id="U368" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.93906093906094" /psig="0.93906093906094" /xcortree=1177 /SigmaFactorBS="tgaggtggcctgtacaataagttcccgtgttcccCGTATGtt tttggaaaatggGAGTATAATGGAAGTAAGAaatcctttattgcaggtaaatataagc a" /listShort="endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 500063 /Source="Nicolas_upshifts" /id="U368" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.93906093906094" /psig="0.93906093906094" /xcortree=1177 /SigmaFactorBS="tgaggtggcctgtacaataagttcccgtgttcccCGTATGtt tttggaaaatggGAGTATAATGGAAGTAAGAaatcctttattgcaggtaaatataagc a" /listShort="endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 500138..500141 /Source="Nicolas_upshift_promotors" /id="U369" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.527472527472527" /psig=1 /xcortree=2132 /SigmaFactorBS="taagcaattaacttacctaaatggagaattcataaaacagCT TTgcttgaagagtgaatAATGGTATCATTATCACTGGatggataaaagagtcgtatcc g" /listShort="endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 500157..500176 /Source="Nicolas_upshift_promotors" /id="U369" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.527472527472527" /psig=1 /xcortree=2132 /SigmaFactorBS="taagcaattaacttacctaaatggagaattcataaaacagCT TTgcttgaagagtgaatAATGGTATCATTATCACTGGatggataaaagagtcgtatcc g" /listShort="endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 500158 /Source="Nicolas_upshifts" /id="U369" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.527472527472527" /psig=1 /xcortree=2132 /SigmaFactorBS="taagcaattaacttacctaaatggagaattcataaaacagCT TTgcttgaagagtgaatAATGGTATCATTATCACTGGatggataaaagagtcgtatcc g" /listShort="endB, ndoA, rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="upshifts" CDS 500224..500505 /gene="ndoAI" /locus_tag="BSU_04650" /old_locus_tag="BSU04650" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15882409, 21763692, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15882409, 21763692, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="antitoxin EndoAI" /protein_id="NP_388346.1" /db_xref="EnsemblGenomes-Gn:BSU04650" /db_xref="EnsemblGenomes-Tr:CAB12272" /db_xref="GOA:P96621" /db_xref="InterPro:IPR002145" /db_xref="InterPro:IPR010985" /db_xref="InterPro:IPR013321" /db_xref="PDB:4ME7" /db_xref="SubtiList:BG12091" /db_xref="UniProtKB/Swiss-Prot:P96621" /translation="MSESSARTEMKISLPENLVAELDGVAMREKRSRNELISQAVRAY VSERTTRHNRDLMRRGYMEMAKINLNISSEAHFAECEAETTVERLVSGG*" /label="ndoAI CDS" gene 500224..500505 /gene="ndoAI" /locus_tag="BSU_04650" /old_locus_tag="BSU04650" /label="ndoAI gene" CDS 500510..500860 /gene="ndoA" /locus_tag="BSU_04660" /old_locus_tag="BSU04660" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15882409, 21763692, 21897862, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15882409, 21763692, 21897862, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endoribonuclease toxin" /protein_id="NP_388347.1" /db_xref="EnsemblGenomes-Gn:BSU04660" /db_xref="EnsemblGenomes-Tr:CAB12273" /db_xref="GOA:P96622" /db_xref="InterPro:IPR003477" /db_xref="InterPro:IPR011067" /db_xref="PDB:1NE8" /db_xref="PDB:4MDX" /db_xref="PDB:4ME7" /db_xref="SubtiList:BG12092" /db_xref="UniProtKB/Swiss-Prot:P96622" /translation="MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTAIV AAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQIRTIDKQRLTDKITHLDDEMMDK VDEALQISLALIDF*" /label="ndoA CDS" gene 500510..500860 /gene="ndoA" /locus_tag="BSU_04660" /old_locus_tag="BSU04660" /label="ndoA gene" S_feature complement(500650..501126) /Source="Nicolas_S_feature" /locus_tag="new_519083_519559_c" /HighExp="Etha, Gly, Sw, S8, C30, S6, LBGstat, T0.30H, S7, Salt" /AntisenseName="ndoA" /AntisenseCor="-0.36117231948253697" /AntisenseRegPval="-9" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigB, SigK" /TUshortPSig="1, 1, 0.973" /TUlongSig="NA" /TUlongPSig="NA" /label="S163" downshifts complement(500693) /Source="Nicolas_upshifts" /id="D223" /incds=1 /nref=6 /ntot=171 /MaxReadThrough="3.51096" /MaxDrop="3.79912" /score="-8.86444162" /energy="-10.2" /TU="U372" /idTUdmin="U371" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" downshifts 500840 /Source="Nicolas_upshifts" /id="D224" /incds=0 /nref=143 /ntot=254 /MaxReadThrough="5.57908" /MaxDrop="5.74865" /score="29.7721113" /energy="-8.9" /TU="U367,U368,U369" /idTUdmin="U366" /TUdmin=799 /isTUend="FALSE" /label="downshifts" promotor_-35 500894..500901 /Source="Nicolas_upshift_promotors" /id="U370" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.772227772227772" /psig="0.999000999001" /xcortree=1992 /SigmaFactorBS="atatttgcaggttgctcaaatagagcaacttTTTTTGTTttc aaaaaacataAACGATATAATAGTGAAATAacgaaaaaatatgttgttttttattggg a" /listShort="rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 500915..500934 /Source="Nicolas_upshift_promotors" /id="U370" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.772227772227772" /psig="0.999000999001" /xcortree=1992 /SigmaFactorBS="atatttgcaggttgctcaaatagagcaacttTTTTTGTTttc aaaaaacataAACGATATAATAGTGAAATAacgaaaaaatatgttgttttttattggg a" /listShort="rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 500923 /Source="Nicolas_upshifts" /id="U370" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.772227772227772" /psig="0.999000999001" /xcortree=1992 /SigmaFactorBS="atatttgcaggttgctcaaatagagcaacttTTTTTGTTttc aaaaaacataAACGATATAATAGTGAAATAacgaaaaaatatgttgttttttattggg a" /listShort="rsbRA, rsbS, rsbT, rsbU, rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="upshifts" CDS 500975..501799 /gene="rsbRA" /locus_tag="BSU_04670" /old_locus_tag="BSU04670" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15312768, 15583165, 16963570, 17158665, 11157946, 20019076, 21362065, 22287516, 23320651, 28271471" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15312768, 15583165, 16963570, 17158665, 11157946, 20019076, 21362065, 22287516, 23320651, 28271471; Product type f: factor" /codon_start=1 /transl_table=11 /product="component of the anxiosome (stressosome); positive regulation of sigma(B) activity in response to salt and heat stress" /protein_id="NP_388348.1" /db_xref="EnsemblGenomes-Gn:BSU04670" /db_xref="EnsemblGenomes-Tr:CAB12274" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR014792" /db_xref="InterPro:IPR036513" /db_xref="PDB:2BNL" /db_xref="SubtiList:BG11090" /db_xref="UniProtKB/Swiss-Prot:P42409" /translation="MMSNQTVYQFIAENQNELLQLWTDTLKELSEQESYQLTDQVYEN ISKEYIDILLLSVKDENAAESQISELALRAVQIGLSMKFLATALAEFWKRLYTKMNDK RLPDQESTELIWQIDRFFSPINTEIFNQYSISWEKTVSLQKIALQELSAPLIPVFENI TVMPLVGTIDTERAKRIMENLLNGVVKHRSQVVLIDITGVPVVDTMVAHHIIQASEAV RLVGAKCLLAGIRPEIAQTIVNLGIDLSQVITKNTLQKGIQTALEMTDRKIVSLGE*" /label="rsbRA CDS" gene 500975..501799 /gene="rsbRA" /locus_tag="BSU_04670" /old_locus_tag="BSU04670" /label="rsbRA gene" promotor_-10 complement(501109..501127) /Source="Nicolas_upshift_promotors" /id="U371" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2828 /SigmaFactorBS="gccagttcgctgatttggctttcagcagcattttcgtcCTTA ACAGacagcagcagaatGTCGATATATTCTTTAGATatattttcatacacttggtcag t" /listShort="S163" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(501126) /Source="Nicolas_upshifts" /id="U371" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2828 /SigmaFactorBS="gccagttcgctgatttggctttcagcagcattttcgtcCTTA ACAGacagcagcagaatGTCGATATATTCTTTAGATatattttcatacacttggtcag t" /listShort="S163" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(501128..501727) /Source="Nicolas_S_feature" /locus_tag="new_519561_520160_c" /HighExp="Etha, Sw, Gly, S6, S8, S7, B60, Salt, BT, M9-stat" /AntisenseName="rsbRA" /AntisenseCor="-0.53924606340364201" /AntisenseRegPval="-21" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigK" /TUshortPSig="1, 0.973" /TUlongSig="NA" /TUlongPSig="NA" /label="S164" promotor_-35 complement(501141..501148) /Source="Nicolas_upshift_promotors" /id="U371" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2828 /SigmaFactorBS="gccagttcgctgatttggctttcagcagcattttcgtcCTTA ACAGacagcagcagaatGTCGATATATTCTTTAGATatattttcatacacttggtcag t" /listShort="S163" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(501716..501734) /Source="Nicolas_upshift_promotors" /id="U372" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=202 /SigmaFactorBS="tgaaacgatttttcgatccgtcatttccaatgcTGTTTGAat tcctttttgcaGGGTATTCTTAGTTATAACttgggataaatcaatccccaggttgacg a" /listShort="S164, S163" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(501727) /Source="Nicolas_upshifts" /id="U372" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=202 /SigmaFactorBS="tgaaacgatttttcgatccgtcatttccaatgcTGTTTGAat tcctttttgcaGGGTATTCTTAGTTATAACttgggataaatcaatccccaggttgacg a" /listShort="S164, S163" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(501729..502317) /Source="Nicolas_S_feature" /locus_tag="new_520162_520750_c" /HighExp="S6, S8, S7, BT, C30, S5, G135, C90, Gly, Fru" /AntisenseName="rsbS" /AntisenseCor="-0.57706416777859804" /AntisenseRegPval="-24.6" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.973" /TUlongSig="NA" /TUlongPSig="NA" /label="S165" promotor_-35 complement(501748..501754) /Source="Nicolas_upshift_promotors" /id="U372" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=202 /SigmaFactorBS="tgaaacgatttttcgatccgtcatttccaatgcTGTTTGAat tcctttttgcaGGGTATTCTTAGTTATAACttgggataaatcaatccccaggttgacg a" /listShort="S164, S163" /GFF_Attribute="listLong" /label="promotor_-35" CDS 501804..502169 /gene="rsbS" /locus_tag="BSU_04680" /old_locus_tag="BSU04680" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15583165, 16963570, 17158665, 11157946, 23320651, 28271471" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15583165, 16963570, 17158665, 11157946, 23320651, 28271471; Product type f : factor" /codon_start=1 /transl_table=11 /product="antagonist of RsbT" /protein_id="NP_388349.1" /db_xref="EnsemblGenomes-Gn:BSU04680" /db_xref="EnsemblGenomes-Tr:CAB12275" /db_xref="GOA:P42410" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR036513" /db_xref="SubtiList:BG11091" /db_xref="UniProtKB/Swiss-Prot:P42410" /translation="MRHPKIPILKLYNCLLVSIQWELDDQTALTFQEDLLNKIYETGA NGVVIDLTSVDMIDSFIAKVLGDVITMSKLMGAKVVLTGIQPAVAVTLIELGIALEEI ETALDLEQGLETLKRELGE*" /label="rsbS CDS" gene 501804..502169 /gene="rsbS" /locus_tag="BSU_04680" /old_locus_tag="BSU04680" /label="rsbS gene" CDS 502173..502574 /gene="rsbT" /locus_tag="BSU_04690" /old_locus_tag="BSU04690" /EC_number="2.7.11.1" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15583165, 16963570, 17158665, 11157946, 20019076, 20558511, 21362065, 21979936, 23320651" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15583165, 16963570, 17158665, 11157946, 20019076, 20558511, 21362065, 21979936, 23320651; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="switch protein/serine-threonine kinase; controlsthe activity of the anxiosome (stressosome)" /protein_id="NP_388350.1" /db_xref="EnsemblGenomes-Gn:BSU04690" /db_xref="EnsemblGenomes-Tr:CAB12276" /db_xref="GOA:P42411" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG11092" /db_xref="UniProtKB/Swiss-Prot:P42411" /translation="MNDQSCVRIMTEWDIVAARQLGRNVAKELGFGTVDQARITTAIS ELARNIYLYAGKGQIGIEQVADRGKKGLKIIAEDQGPGIPDIRKVMEDGFSTSGGLGA GLPGVKRLMDEFSLNSVAGEGTEIQAIKWLR*" /label="rsbT CDS" gene 502173..502574 /gene="rsbT" /locus_tag="BSU_04690" /old_locus_tag="BSU04690" /label="rsbT gene" promotor_-10 complement(502315..502334) /Source="Nicolas_upshift_promotors" /id="U373" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=1334 /SigmaFactorBS="ttttcaggcctttttttcctctgtctgcgacctgtTCAATTC CAAtctgccctttgccGGCATATAAATAAATATTCCtggctaattctgaaatagccgt t" /listShort="S165, S164, S163" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(502332) /Source="Nicolas_upshifts" /id="U373" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=1334 /SigmaFactorBS="ttttcaggcctttttttcctctgtctgcgacctgtTCAATTC CAAtctgccctttgccGGCATATAAATAAATATTCCtggctaattctgaaatagccgt t" /listShort="S165, S164, S163" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(502348..502357) /Source="Nicolas_upshift_promotors" /id="U373" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=1334 /SigmaFactorBS="ttttcaggcctttttttcctctgtctgcgacctgtTCAATTC CAAtctgccctttgccGGCATATAAATAAATATTCCtggctaattctgaaatagccgt t" /listShort="S165, S164, S163" /GFF_Attribute="listLong" /label="promotor_-35" CDS 502586..503593 /gene="rsbU" /locus_tag="BSU_04700" /old_locus_tag="BSU04700" /EC_number="3.1.3.3" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15583165, 16963570, 17158665, 17303566, 21979936, 28461450" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15583165, 16963570, 17158665, 17303566, 21979936, 28461450; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="protein serine phosphatase; controls the activity of the anxiosome (stressosome)" /protein_id="NP_388351.1" /db_xref="EnsemblGenomes-Gn:BSU04700" /db_xref="EnsemblGenomes-Tr:CAB12277" /db_xref="GOA:P40399" /db_xref="InterPro:IPR001932" /db_xref="InterPro:IPR014787" /db_xref="InterPro:IPR017944" /db_xref="InterPro:IPR036457" /db_xref="PDB:1W53" /db_xref="PDB:2J6Y" /db_xref="PDB:2J6Z" /db_xref="PDB:2J70" /db_xref="SubtiList:BG11057" /db_xref="UniProtKB/Swiss-Prot:P40399" /translation="MDFREVIEQRYHQLLSRYIAELTETSLYQAQKFSRKTIEHQIPP EEIISIHRKVLKELYPSLPEDVFHSLDFLIEVMIGYGMAYQEHQTLRGIQQEIKSEIE IAANVQQTLLGTKVPQEEALDIGAISVPAKQMSGDYYHFVKDKESINIAIADVIGKGI PAALCMSMIKYAMDSLPETGIHPSQVLKNLNRVVEQNVDASMFITMFYANYNMDKHQF TYASAGHEPGFYYSQKDNTFYDLEAKGLVLGISQDYDYKQFDQHLEKGDMIVLFSDGV TECRTENGFLERPDLQKLIEEHMCSSAQEMVKNIYDSLLKLQDFQLHDDFTLIVLRRK V*" /label="rsbU CDS" gene 502586..503593 /gene="rsbU" /locus_tag="BSU_04700" /old_locus_tag="BSU04700" /label="rsbU gene" promotor_-35 503587..503593 /Source="Nicolas_upshift_promotors" /id="U374" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=260 /SigmaFactorBS="cgatgattttacgttaattgttttgcggagaaaGGTTTAAcg tctgtcagacgaGGGTATAAAGCAACTAGTGatttgaaggaaaatttgaggtgatacg a" /listShort="rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 503608..503626 /Source="Nicolas_upshift_promotors" /id="U374" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=260 /SigmaFactorBS="cgatgattttacgttaattgttttgcggagaaaGGTTTAAcg tctgtcagacgaGGGTATAAAGCAACTAGTGatttgaaggaaaatttgaggtgatacg a" /listShort="rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 503614 /Source="Nicolas_upshifts" /id="U374" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=260 /SigmaFactorBS="cgatgattttacgttaattgttttgcggagaaaGGTTTAAcg tctgtcagacgaGGGTATAAAGCAACTAGTGatttgaaggaaaatttgaggtgatacg a" /listShort="rsbV, rsbW, sigB, rsbX" /GFF_Attribute="listLong" /label="upshifts" CDS 503655..503984 /gene="rsbV" /locus_tag="BSU_04710" /old_locus_tag="BSU04710" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15342585, 15583165, 16077134, 16885458, 20454630, 21979936, 27977677" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15342585, 15583165, 16077134, 16885458, 20454630, 21979936, 27977677; Product type f: factor" /codon_start=1 /transl_table=11 /product="anti-anti-sigma factor (antagonist of RsbW)" /protein_id="NP_388352.1" /db_xref="EnsemblGenomes-Gn:BSU04710" /db_xref="EnsemblGenomes-Tr:CAB12278" /db_xref="GOA:P17903" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR003658" /db_xref="InterPro:IPR036513" /db_xref="SubtiList:BG10733" /db_xref="UniProtKB/Swiss-Prot:P17903" /translation="MNINVDVKQNENDIQVNIAGEIDVYSAPVLREKLVPLAEQGADL RICLKDVSYMDSTGLGVFVGTFKMVKKQGGSLKLENLSERLIRLFDITGLKDIIDISA KSEGGVQ*" /label="rsbV CDS" gene 503655..503984 /gene="rsbV" /locus_tag="BSU_04710" /old_locus_tag="BSU04710" /label="rsbV gene" CDS 503981..504463 /gene="rsbW" /locus_tag="BSU_04720" /old_locus_tag="BSU04720" /EC_number="2.7.11.1" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15342585, 15583165, 16077134, 16885458, 21979936, 27977677" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15342585, 15583165, 16077134, 16885458, 21979936, 27977677; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="switch protein/serine kinase and anti-sigma factor (inhibitory sigma-B binding protein)" /protein_id="NP_388353.1" /db_xref="EnsemblGenomes-Gn:BSU04720" /db_xref="EnsemblGenomes-Tr:CAB12279" /db_xref="GOA:P17904" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR010193" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG10734" /db_xref="UniProtKB/Swiss-Prot:P17904" /translation="MKNNADYIEMKVPAQPEYVGIIRLTLSGVASRMGYTYDEIEDLK IAVSEACTNAVQHAYKEDKNGEVSIRFGVFEDRLEVIVADEGDSFDFDQKQQDLGPYT PSHTVDQLSEGGLGLYLMETLMDEVRVQNHSGVTVAMTKYLNGERVDHDTTIKNYETN *" /label="rsbW CDS" gene 503981..504463 /gene="rsbW" /locus_tag="BSU_04720" /old_locus_tag="BSU04720" /label="rsbW gene" CDS 504429..505217 /gene="sigB" /locus_tag="BSU_04730" /old_locus_tag="BSU04730" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15312768, 15805528, 16077134, 16267279, 16321960, 17158665, 28271471" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15312768, 15805528, 16077134, 16267279, 16321960, 17158665, 28271471; Product type r: regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase sigma-37 factor (sigma(B))" /protein_id="NP_388354.2" /db_xref="EnsemblGenomes-Gn:BSU04730" /db_xref="EnsemblGenomes-Tr:CAB12280" /db_xref="GOA:P06574" /db_xref="InterPro:IPR000943" /db_xref="InterPro:IPR007624" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR007630" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR014288" /db_xref="InterPro:IPR014322" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10735" /db_xref="UniProtKB/Swiss-Prot:P06574" /translation="MTQPSKTTKLTKDEVDRLISDYQTKQDEQAQETLVRVYTNLVDM LAKKYSKGKSFHEDLRQVGMIGLLGAIKRYDPVVGKSFEAFAIPTIIGEIKRFLRDKT WSVHVPRRIKELGPRIKMAVDQLTTETQRSPKVEEIAEFLDVSEEEVLETMEMGKSYQ ALSVDHSIEADSDGSTVTILDIVGSQEDGYERVNQQLMLQSVLHVLSDREKQIIDLTY IQNKSQKETGDILGISQMHVSRLQRKAVKKLREALIEDPSMELM*" /label="sigB CDS" gene 504429..505217 /gene="sigB" /locus_tag="BSU_04730" /old_locus_tag="BSU04730" /label="sigB gene" CDS 505217..505816 /gene="rsbX" /locus_tag="BSU_04740" /old_locus_tag="BSU04740" /EC_number="3.1.3.3" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10671474, 12950928, 15466036, 9068644, 9658013, 21979936, 26057679" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10671474, 12950928, 15466036, 9068644, 9658013, 21979936, 26057679; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="serine phosphatase" /protein_id="NP_388355.1" /db_xref="EnsemblGenomes-Gn:BSU04740" /db_xref="EnsemblGenomes-Tr:CAB12281" /db_xref="GOA:P17906" /db_xref="InterPro:IPR001932" /db_xref="InterPro:IPR036457" /db_xref="PDB:3W40" /db_xref="PDB:3W41" /db_xref="PDB:3W42" /db_xref="PDB:3W43" /db_xref="PDB:3W44" /db_xref="PDB:3W45" /db_xref="SubtiList:BG10736" /db_xref="UniProtKB/Swiss-Prot:P17906" /translation="MIQVEENEHIQTLVYQLNKEGKSICGDSFFMKADDKELICAVAD GLGSGSLANESSAAIKDLVENYASEDVESIIERCNQAMKNKRGATASILKINFEQRQF TYCSVGNVRFILHSPSGESFYPLPISGYLSGKPQKYKTHTATYEKGSKFIIHTDGLNV PDIRSHLKKGQSVEEISNSLKMYTTSRKDDLTYILGQLS*" /label="rsbX CDS" gene 505217..505816 /gene="rsbX" /locus_tag="BSU_04740" /old_locus_tag="BSU04740" /label="rsbX gene" downshifts 505802 /Source="Nicolas_upshifts" /id="D225" /incds=0 /nref=267 /ntot=278 /MaxReadThrough="2.46753" /MaxDrop="7.92167" /score="1.26147577" /energy="-6" /TU="NA" /idTUdmin="U369" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" promotor_-35 505860..505866 /Source="Nicolas_upshift_promotors" /id="U375" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.427572427572428" /psig=1 /xcortree=2529 /SigmaFactorBS="gctggacatccggcttcttttttttgcGGTTGACtattaata agtgcgCTTATTATAATTAATAAGTGaacttatcattctgggagcttatgggatgtgg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 505881..505900 /Source="Nicolas_upshift_promotors" /id="U375" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.427572427572428" /psig=1 /xcortree=2529 /SigmaFactorBS="gctggacatccggcttcttttttttgcGGTTGACtattaata agtgcgCTTATTATAATTAATAAGTGaacttatcattctgggagcttatgggatgtgg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" Polymorphism join(505889,505891) /Source="geneious" /ID="SNP_BsDelta6_524323_524323" /Polymorphism_Type="SNP (transversion)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change /CDS_Position /Change="A -> C" /Codon_Change /Coverage=183 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides="A" /Variant_Nucleotides="C" /Variant_P_Value=0 /Variant_Raw_Frequency=183 /comment="BSU_04745_promoter_down_mutation" /modified_by="User" / /label="Polymorphism_Delta6" upshifts 505893 /Source="Nicolas_upshifts" /id="U375" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.427572427572428" /psig=1 /xcortree=2529 /SigmaFactorBS="gctggacatccggcttcttttttttgcGGTTGACtattaata agtgcgCTTATTATAATTAATAAGTGaacttatcattctgggagcttatgggatgtgg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 505927..506043 /locus_tag="BSU_04745" /old_locus_tag="BSU04745" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513945.1" /translation="MWNYEYTAIADVDVGKPGTVIRKQKQWINGRRVLHQIL*" /label="hypothetical protein CDS" gene 505927..506043 /locus_tag="BSU_04745" /old_locus_tag="BSU04745" /label="gene" CDS 506059..506352 /gene="ydcF" /locus_tag="BSU_04750" /old_locus_tag="BSU04750" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388356.1" /db_xref="EnsemblGenomes-Gn:BSU04750" /db_xref="EnsemblGenomes-Tr:CAB12282" /db_xref="SubtiList:BG12093" /db_xref="UniProtKB/Swiss-Prot:P96623" /translation="MERKEHCFCKEKQFSYGLSMWRNIGRFLSWSTCPHSNVIMEFFH VLQKQKEDLCITYGIVLEGAEAKKWGEIIGTELSKDMPTAVSRLVHLYGGVIK*" /label="ydcF CDS" gene 506059..506352 /gene="ydcF" /locus_tag="BSU_04750" /old_locus_tag="BSU04750" /label="ydcF gene" promotor_-35 506320..506328 /Source="Nicolas_upshift_promotors" /id="U376" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.65034965034965" /psig=1 /xcortree=2272 /SigmaFactorBS="agacatgccgacggctgtcagcaggCTTGTCCATctttacgg aggAGTGATAAAATGAACACAAAttactggatcggcgttgtgtcagagcaacatgtat t" /listShort="ydcG, ydcH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 506340..506359 /Source="Nicolas_upshift_promotors" /id="U376" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.65034965034965" /psig=1 /xcortree=2272 /SigmaFactorBS="agacatgccgacggctgtcagcaggCTTGTCCATctttacgg aggAGTGATAAAATGAACACAAAttactggatcggcgttgtgtcagagcaacatgtat t" /listShort="ydcG, ydcH" /GFF_Attribute="listLong" /label="promotor_-10" CDS 506349..506789 /gene="ydcG" /locus_tag="BSU_04760" /old_locus_tag="BSU04760" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388357.1" /db_xref="EnsemblGenomes-Gn:BSU04760" /db_xref="EnsemblGenomes-Tr:CAB12283" /db_xref="InterPro:IPR002740" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR022996" /db_xref="SubtiList:BG12094" /db_xref="UniProtKB/Swiss-Prot:P96624" /translation="MNTNYWIGVVSEQHVLKGAAGGFAQLCHGKKAPLAKMKEGDWLI YYSPRDAYPDGKLLRSFTAIGKVKSGNIYPYQMAPNFIPYRLDIDYYPCHKIGFYDIK SKLEFVQETKHLGFLFRRGHFEISKKDFLTIAQAMGVNISGMAL*" /label="ydcG CDS" gene 506349..506789 /gene="ydcG" /locus_tag="BSU_04760" /old_locus_tag="BSU04760" /label="ydcG gene" upshifts 506355 /Source="Nicolas_upshifts" /id="U376" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.65034965034965" /psig=1 /xcortree=2272 /SigmaFactorBS="agacatgccgacggctgtcagcaggCTTGTCCATctttacgg aggAGTGATAAAATGAACACAAAttactggatcggcgttgtgtcagagcaacatgtat t" /listShort="ydcG, ydcH" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(506588..509643) /Source="Nicolas_S_feature" /locus_tag="new_525021_528076_c" /HighExp="S6, S8, S7, S5, B36, S4, B60, BT, Pyr, C30" /AntisenseName="ydcI" /AntisenseCor="-0.61304426345041496" /AntisenseRegPval="-28.4" /CDS_PredictionProba="0.40759499999999999" /TUshortSig="SigK" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S166" CDS 506773..507216 /gene="ydcH" /locus_tag="BSU_04770" /old_locus_tag="BSU04770" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12088660; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_388358.1" /db_xref="EnsemblGenomes-Gn:BSU04770" /db_xref="EnsemblGenomes-Tr:CAB12284" /db_xref="GOA:P96625" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12095" /db_xref="UniProtKB/Swiss-Prot:P96625" /translation="MEWHSKFSGPNTSPGFLLWQATQSWQRKVGKALAEFDLTHVQFV LLTSCKYMIAHGETVTQKKLASFSQTNIMMVSEVVRTLEKKGFIERSKNPQDKREVLL SLTEIGGEKVTAALPIVEKIDQAFFAAAMKKENFLSGLQELLKHE*" /label="ydcH CDS" gene 506773..507216 /gene="ydcH" /locus_tag="BSU_04770" /old_locus_tag="BSU04770" /label="ydcH gene" downshifts 507191 /Source="Nicolas_upshifts" /id="D226" /incds=0 /nref=11 /ntot=147 /MaxReadThrough="2.17786" /MaxDrop="3.86856" /score="21.3746204" /energy="-6.8" /TU="NA" /idTUdmin="U376" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 507247..507248 /Source="Nicolas_upshift_promotors" /id="U377" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.712287712287712" /psig="0.997002997002997" /xcortree=1998 /SigmaFactorBS="gaaacatgagtaaagatacgggcagcgccagctgtctttttt tATgtgtttttttcggttTTTGATACACTAGAGAAAGAacgacaaaattggaggcttt g" /listShort="ydcI, S167, ydcK" /listLong="S168, trnS-Asn, trnS-Ser, trnS-Glu, trnS-Gln, trnS-Lys, trnS-Leu1, trnS-Leu2" /label="promotor_-35" promotor_-10 507264..507283 /Source="Nicolas_upshift_promotors" /id="U377" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.712287712287712" /psig="0.997002997002997" /xcortree=1998 /SigmaFactorBS="gaaacatgagtaaagatacgggcagcgccagctgtctttttt tATgtgtttttttcggttTTTGATACACTAGAGAAAGAacgacaaaattggaggcttt g" /listShort="ydcI, S167, ydcK" /listLong="S168, trnS-Asn, trnS-Ser, trnS-Glu, trnS-Gln, trnS-Lys, trnS-Leu1, trnS-Leu2" /label="promotor_-10" upshifts 507264 /Source="Nicolas_upshifts" /id="U377" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.712287712287712" /psig="0.997002997002997" /xcortree=1998 /SigmaFactorBS="gaaacatgagtaaagatacgggcagcgccagctgtctttttt tATgtgtttttttcggttTTTGATACACTAGAGAAAGAacgacaaaattggaggcttt g" /listShort="ydcI, S167, ydcK" /listLong="S168, trnS-Asn, trnS-Ser, trnS-Glu, trnS-Gln, trnS-Lys, trnS-Leu1, trnS-Leu2" /label="upshifts" CDS 507310..509469 /gene="tex" /locus_tag="BSU_04780" /old_locus_tag="BSU04780" /function="16.3: Control" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8755871, 12910271, 15383836, 16282592; Product type f: factor" /codon_start=1 /transl_table=11 /product="RNA helicase transcriptional accessory protein" /protein_id="NP_388359.2" /db_xref="EnsemblGenomes-Gn:BSU04780" /db_xref="EnsemblGenomes-Tr:CAB12285" /db_xref="GOA:O31489" /db_xref="InterPro:IPR003029" /db_xref="InterPro:IPR006641" /db_xref="InterPro:IPR010994" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR018974" /db_xref="InterPro:IPR022967" /db_xref="InterPro:IPR023319" /db_xref="InterPro:IPR023323" /db_xref="InterPro:IPR032639" /db_xref="SubtiList:BG12096" /db_xref="UniProtKB/Swiss-Prot:O31489" /translation="METSALLKQQIAKEIGLSQKHVESVIRLLEDGNTVPFIARYRKE QTGSMDEVQIQTISERWQYIQNLNQRKEEVIRLIAEQDKLTDNLKRKIEQSVKLQEVE DLYRPYKQKRKTKATVAKSKGLEPLADYILTLPQDDHLAATADQYISEEKEVFTREEA IEGAKHIIAEQISDEPTFRKWIRQETFKRGTIKSAAGKSADTDEKNVYEMYYEYEEPI AKVVPHRVLAMNRGEKEDILKVAIEPPADHIKAYLEKQIIKNRSTSVREILQETIEDS YKRLIQPAIEREIRKELSEKADEQAIHIFSENLRKLLLQPPMKGKTVLGVDPAFRTGC KLAVSDETGKVLKIDVIYPHAPVNKTKEAHEKVKKILEQYQVEMVAIGNGTASRETEQ FIVNVLRDMPRKIYYVIVNEAGASVYSASELAREEFPDLKVEERSAVSIARRLQDPLA ELVKIDPKSVGVGQYQHDVSQKRLNESLRFVVETVVNQVGVNVNTASAALLQYVAGLS KSVAGNVVKKREEIGKFSNRKELKDIPRLGAKTYEQCIGFLRVQEGTEPLDRTGIHPE SYKETKALLKKLGLSTEHIGTAELKDKINQLALSETAKELGIGEITLKDICEQLTRPE RDPRDKVPKPLLKTDVLQLEDLKEGMELQGTVRNVVDFGAFVDIGVKQDGLVHISKLS NQFVKHPLDVVSVGDIVTVWVDGVDVQKGRVSLSMVK*" /label="tex CDS" gene 507310..509469 /gene="tex" /locus_tag="BSU_04780" /old_locus_tag="BSU04780" /label="tex gene" misc_feature 509457..509476 /Source="Nicolas_upshift_promotors" /id="U378" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig="0.999000999001" /xcortree=2162 /SigmaFactorBS="gacggcgtagatgtacaaaaaggcagagtatcgctgtcTATG GTAAAATAAAAGCACTgcttacgagcagtgttttttcctatagaaataccagcattga t" /listShort="S167, ydcK, S168, trnS-Asn, trnS-Ser, trnS-Glu, trnS-Gln, trnS-Lys, trnS-Leu1" /listLong="trnS-Leu2, S169" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 509479..509695 /Source="Nicolas_S_feature" /locus_tag="new_527912_528128" /HighExp="Cold, Etha, LBGstat, dia5, LPhT, T4.0H, dia15, T3.0H, T2.30H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S167" upshifts 509479 /Source="Nicolas_upshifts" /id="U378" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig="0.999000999001" /xcortree=2162 /SigmaFactorBS="gacggcgtagatgtacaaaaaggcagagtatcgctgtcTATG GTAAAATAAAAGCACTgcttacgagcagtgttttttcctatagaaataccagcattga t" /listShort="S167, ydcK, S168, trnS-Asn, trnS-Ser, trnS-Glu, trnS-Gln, trnS-Lys, trnS-Leu1" /listLong="trnS-Leu2, S169" /label="upshifts" CDS complement(509479..509592) /gene="cmpA" /locus_tag="BSU_04785" /old_locus_tag="BSU04785" /function="16.3: Control" /function="16.6: Maintain" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:22463703, 26387458" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22463703, 26387458; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor allowing degradation of SpoIVA by ClpXP" /protein_id="YP_009513946.1" /translation="MPNWLKKQMQKAFLEKDNYQIKLLNQCWYFYRKKHCS*" /label="cmpA CDS" gene complement(509479..509592) /gene="cmpA" /locus_tag="BSU_04785" /old_locus_tag="BSU04785" /label="cmpA gene" promotor_-10 complement(509632..509651) /Source="Nicolas_upshift_promotors" /id="U379" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1320 /SigmaFactorBS="tctttgttatccatggtgcacctcacttaaaaaacATTGAAC GGgacaattcaccgttCGCATACAATATGGTAATCActgtccctcttatgataaaagc t" /listShort="S166" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(509649) /Source="Nicolas_upshifts" /id="U379" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1320 /SigmaFactorBS="tctttgttatccatggtgcacctcacttaaaaaacATTGAAC GGgacaattcaccgttCGCATACAATATGGTAATCActgtccctcttatgataaaagc t" /listShort="S166" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(509666..509674) /Source="Nicolas_upshift_promotors" /id="U379" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1320 /SigmaFactorBS="tctttgttatccatggtgcacctcacttaaaaaacATTGAAC GGgacaattcaccgttCGCATACAATATGGTAATCActgtccctcttatgataaaagc t" /listShort="S166" /GFF_Attribute="listLong" /label="promotor_-35" CDS 509696..510148 /gene="ydcK" /locus_tag="BSU_04790" /old_locus_tag="BSU04790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388360.1" /db_xref="EnsemblGenomes-Gn:BSU04790" /db_xref="EnsemblGenomes-Tr:CAB12286" /db_xref="GOA:P96628" /db_xref="InterPro:IPR006640" /db_xref="InterPro:IPR023524" /db_xref="InterPro:IPR035240" /db_xref="SubtiList:BG12098" /db_xref="UniProtKB/Swiss-Prot:P96628" /translation="MDNKELQKLTEDISETYFKKPFRHQALFNDRLKTTGGRYLLTSH NIELNRKYLIEHGREELIGIIKHELCHYHLHLEGKGYKHRDRDFRMLLQQVNAPRFCT PLKKKAENKKTYMYICTTCGQQYIKKRAMNPDRYRCGKCRGKIKRIFS*" /label="ydcK CDS" gene 509696..510148 /gene="ydcK" /locus_tag="BSU_04790" /old_locus_tag="BSU04790" /label="ydcK gene" promotor_-35 510154..510160 /Source="Nicolas_upshift_promotors" /id="U380" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2626 /SigmaFactorBS="gaaaaataaaaagaattttttcgtgaaaaagGTTGACGaata tggcaagcctATGTTACATTATAAAAGTCGtcacgagagataaataaaaacatttacc t" /listShort="S168, trnS-Asn, trnS-Ser, trnS-Glu, trnS-Gln, trnS-Lys, trnS-Leu1, trnS-Leu2, S169" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 510175..510194 /Source="Nicolas_upshift_promotors" /id="U380" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2626 /SigmaFactorBS="gaaaaataaaaagaattttttcgtgaaaaagGTTGACGaata tggcaagcctATGTTACATTATAAAAGTCGtcacgagagataaataaaaacatttacc t" /listShort="S168, trnS-Asn, trnS-Ser, trnS-Glu, trnS-Gln, trnS-Lys, trnS-Leu1, trnS-Leu2, S169" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 510183..510270 /Source="Nicolas_S_feature" /locus_tag="new_528616_528703" /HighExp="C30, LBGstat, Cold, UNK1, GM 25, GM 120, GM 15, Heat, T-3.40H, GM 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="SigA" /TUlongPSig="0.997" /label="S168" upshifts 510183 /Source="Nicolas_upshifts" /id="U380" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2626 /SigmaFactorBS="gaaaaataaaaagaattttttcgtgaaaaagGTTGACGaata tggcaagcctATGTTACATTATAAAAGTCGtcacgagagataaataaaaacatttacc t" /listShort="S168, trnS-Asn, trnS-Ser, trnS-Glu, trnS-Gln, trnS-Lys, trnS-Leu1, trnS-Leu2, S169" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(510215) /Source="Nicolas_upshifts" /id="D227" /incds=0 /nref=1 /ntot=28 /MaxReadThrough="2.50342" /MaxDrop="3.97305" /score="8.78044068" /energy="-9.2" /TU="NA" /idTUdmin="U381" /TUdmin=704 /isTUend="FALSE" /label="downshifts" tRNA 510271..510345 /gene="trnS-Asn" /locus_tag="BSU_tRNA_45" /product="tRNA-Asn" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Asn(GUU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnS-Asn tRNA" gene 510271..510345 /gene="trnS-Asn" /locus_tag="BSU_tRNA_45" /label="trnS-Asn gene" tRNA 510350..510440 /gene="trnS-Ser" /locus_tag="BSU_tRNA_46" /product="tRNA-Ser" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ser(GCU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnS-Ser tRNA" gene 510350..510440 /gene="trnS-Ser" /locus_tag="BSU_tRNA_46" /label="trnS-Ser gene" tRNA 510470..510541 /gene="trnS-Glu" /locus_tag="BSU_tRNA_47" /product="tRNA-Glu" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnS-Glu tRNA" gene 510470..510541 /gene="trnS-Glu" /locus_tag="BSU_tRNA_47" /label="trnS-Glu gene" tRNA 510553..510627 /gene="trnS-Gln" /locus_tag="BSU_tRNA_48" /product="tRNA-Gln" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Gln(UUG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnS-Gln tRNA" gene 510553..510627 /gene="trnS-Gln" /locus_tag="BSU_tRNA_48" /label="trnS-Gln gene" tRNA 510654..510729 /gene="trnS-Lys" /locus_tag="BSU_tRNA_49" /product="tRNA-Lys" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Lys(UUU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnS-Lys tRNA" gene 510654..510729 /gene="trnS-Lys" /locus_tag="BSU_tRNA_49" /label="trnS-Lys gene" tRNA 510741..510822 /gene="trnS-Leu1" /locus_tag="BSU_tRNA_50" /product="tRNA-Leu" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Leu(UAG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnS-Leu1 tRNA" gene 510741..510822 /gene="trnS-Leu1" /locus_tag="BSU_tRNA_50" /label="trnS-Leu1 gene" downshifts 510887 /Source="Nicolas_upshifts" /id="D228" /incds=0 /nref=3 /ntot=136 /MaxReadThrough="6.94232" /MaxDrop="3.5424" /score="34.987622" /energy="-13.7" /TU="U380" /idTUdmin="U378" /TUdmin=0 /isTUend="TRUE" /label="downshifts" tRNA 510903..>510988 /gene="trnS-Leu2" /locus_tag="BSU_tRNA_51" /product="tRNA-Leu" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Leu (GAG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnS-Leu2 tRNA" gene 510903..>510988 /gene="trnS-Leu2" /locus_tag="BSU_tRNA_51" /modified_by="User" /label="trnS-Leu2 gene" SCAR 510988..510989 /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="Delta6_2" S_feature complement(<510989..511295) /Source="Nicolas_S_feature" /locus_tag="new_549923_550239_c" /HighExp="Diami, dia15, dia5, HPh, Etha, H2O2, Cold, LPh, C90, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /modified_by="User" /label="S175" downshifts 511008 /Source="Nicolas_upshifts" /id="D238" /incds=0 /nref=3 /ntot=115 /MaxReadThrough="0.144629999999999" /MaxDrop="3.58923" /score="4.45688042" /energy="-12.2" /TU="NA" /idTUdmin="U389" /TUdmin=84 /isTUend="FALSE" /label="downshifts" downshifts complement(511040) /Source="Nicolas_upshifts" /id="D239" /incds=0 /nref=3 /ntot=21 /MaxReadThrough="2.31925" /MaxDrop="3.67068" /score="-2.66780619" /energy="-18.7" /TU="NA" /idTUdmin="U391" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(511296..512315) /gene="yddN" /locus_tag="BSU_05040" /old_locus_tag="BSU05040" /EC_number="1.14.14.-" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9836433; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative alkanal monooxygenase" /protein_id="NP_388385.1" /db_xref="EnsemblGenomes-Gn:BSU05040" /db_xref="EnsemblGenomes-Tr:CAB12311" /db_xref="GOA:P96651" /db_xref="InterPro:IPR011251" /db_xref="InterPro:IPR019949" /db_xref="InterPro:IPR036661" /db_xref="SubtiList:BG12121" /db_xref="UniProtKB/Swiss-Prot:P96651" /translation="MKKFDISVLSVAPLRQGETMKQGIDSAVSLAKAVDNMGYKRIWF AEHHNHDAYASAATVSIVQHILANTKDIRVGSGGIMLPNHSPLIVAEQFGTLETLYPN RVDLALGRAPGTDQKTADVIRRSNHNGVFFFEREVNDILRFVGDKSVQGEVRAYPGIG THVPVFVLGSSTDSAEIAAKLGLPYAFGAQFSPHSMEEALSIYRENFQPSSYLQEPYV IACINVIAAESIDEASFISASHLQVYIDIYTNNLSKLIPPTENFLESLSQFELEILHS RLGYTIMGDRETIRRELIDFQQMYHADELIVLSNIYELSKEIQSYEILKQVVDELFKK RMEQL*" /label="yddN CDS" gene complement(511296..512315) /gene="yddN" /locus_tag="BSU_05040" /old_locus_tag="BSU05040" /label="yddN gene" promotor_-10 complement(511991..512010) /Source="Nicolas_upshift_promotors" /id="U391" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig="0.999000999001" /xcortree=1980 /SigmaFactorBS="ttccccattaatcgtagcggagcaatttggaaCACTTGAAac attatatccaaaTCGTGTAGATTTGGCATTAGgacgcgcacccggaacggatcaaaaa a" /listShort="S175" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(512004) /Source="Nicolas_upshifts" /id="U391" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig="0.999000999001" /xcortree=1980 /SigmaFactorBS="ttccccattaatcgtagcggagcaatttggaaCACTTGAAac attatatccaaaTCGTGTAGATTTGGCATTAGgacgcgcacccggaacggatcaaaaa a" /listShort="S175" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(512025..512032) /Source="Nicolas_upshift_promotors" /id="U391" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig="0.999000999001" /xcortree=1980 /SigmaFactorBS="ttccccattaatcgtagcggagcaatttggaaCACTTGAAac attatatccaaaTCGTGTAGATTTGGCATTAGgacgcgcacccggaacggatcaaaaa a" /listShort="S175" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 512104..512108 /Source="Nicolas_upshift_promotors" /id="U392" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2543 /SigmaFactorBS="ttggcaacataataccccctgaacctacgcgaatgTCTTTtg tatttgctaatataTGTTGTACAATTGATACGGTtgctgcacttgcataagcgtcgtg a" /listShort="S176, lrpA, S177" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 512125..512144 /Source="Nicolas_upshift_promotors" /id="U392" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2543 /SigmaFactorBS="ttggcaacataataccccctgaacctacgcgaatgTCTTTtg tatttgctaatataTGTTGTACAATTGATACGGTtgctgcacttgcataagcgtcgtg a" /listShort="S176, lrpA, S177" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 512129 /Source="Nicolas_upshifts" /id="U392" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2543 /SigmaFactorBS="ttggcaacataataccccctgaacctacgcgaatgTCTTTtg tatttgctaatataTGTTGTACAATTGATACGGTtgctgcacttgcataagcgtcgtg a" /listShort="S176, lrpA, S177" /GFF_Attribute="listLong" /label="upshifts" S_feature 512130..512574 /Source="Nicolas_S_feature" /locus_tag="new_551074_551518" /HighExp="dia15, dia5, H2O2, G180, G135, Paraq, HPh, LBGexp, Lbexp, G150" /AntisenseName="yddN" /AntisenseCor="0.70327972625798696" /AntisenseRegPval="-40.700000000000003" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S176" CDS 512575..512985 /gene="lrpA" /locus_tag="BSU_05050" /old_locus_tag="BSU05050" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11902725, 12675791, 17223133" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11902725, 12675791, 17223133; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (Lrp/AsnC family)" /protein_id="NP_388386.1" /db_xref="EnsemblGenomes-Gn:BSU05050" /db_xref="EnsemblGenomes-Tr:CAB12312" /db_xref="GOA:P96652" /db_xref="InterPro:IPR000485" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR019887" /db_xref="InterPro:IPR019888" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12122" /db_xref="UniProtKB/Swiss-Prot:P96652" /translation="MIDEIDKKILDELSKNSRLTMKKLGEKVHLTAPATASRVVKLID NGIIKGCSIEVNQVKLGFSIHAFLNIYIEKIHHQPYLAFIETQDNYVINNYKVSGDGC YLLECKFPSNEVLDQFLNDLNKHANYKVSIVIGK*" /label="lrpA CDS" gene 512575..512985 /gene="lrpA" /locus_tag="BSU_05050" /old_locus_tag="BSU05050" /label="lrpA gene" S_feature 512986..513055 /Source="Nicolas_S_feature" /locus_tag="new_551930_551999" /HighExp="dia15, dia5, H2O2, HPh, G180, G135, LBGtran, Paraq, dia0, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S177" downshifts 513012 /Source="Nicolas_upshifts" /id="D240" /incds=0 /nref=45 /ntot=194 /MaxReadThrough="2.99689" /MaxDrop="3.6808" /score="-1.98969146" /energy="-15.7" /TU="U392" /idTUdmin="U392" /TUdmin="-350" /isTUend="FALSE" /label="downshifts" CDS complement(513108..513557) /gene="lrpB" /locus_tag="BSU_05060" /old_locus_tag="BSU05060" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11902725, 12675791, 17223133" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11902725, 12675791, 17223133; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (Lrp/AsnC family)" /protein_id="NP_388387.1" /db_xref="EnsemblGenomes-Gn:BSU05060" /db_xref="EnsemblGenomes-Tr:CAB12313" /db_xref="GOA:P96653" /db_xref="InterPro:IPR000485" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR019887" /db_xref="InterPro:IPR019888" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12123" /db_xref="UniProtKB/Swiss-Prot:P96653" /translation="MQIDSIDFQILQLLNKNARIQWKEIGEKIHMTGQAVGNRIKKME DNGIIKAYSIVVDELKMGFSFTAFVFFFMNAYMHDDLLKFIATRNEISEAHRVSGDAC YLLKVTVHSQEVLNHLLNDLLKYGNYQLYLSIKEVKKHYNTSLMSDE*" /label="lrpB CDS" gene complement(513108..513557) /gene="lrpB" /locus_tag="BSU_05060" /old_locus_tag="BSU05060" /label="lrpB gene" CDS 513672..514214 /gene="yddQ" /locus_tag="BSU_05070" /old_locus_tag="BSU05070" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_388388.1" /db_xref="EnsemblGenomes-Gn:BSU05070" /db_xref="EnsemblGenomes-Tr:CAB12314" /db_xref="GOA:P96654" /db_xref="InterPro:IPR000868" /db_xref="InterPro:IPR036380" /db_xref="SubtiList:BG12124" /db_xref="UniProtKB/Swiss-Prot:P96654" /translation="MTTALLVIDIQNDYFPNGKMALTNPEKAAQNAAKLLSHFRNTGA PVFHVQHITEGNIAHFFHPNTEGVEIHESVRPLEKETVIVKHMPNSFFNTDLNGKLQE EGVKELVVCGMMSHMCIDATVRSAVEHGYVCQVVEDACATTTLQIEDKIVPAEHVHYA FMAALNGVYATVKTTEAFLK*" /label="yddQ CDS" gene 513672..514214 /gene="yddQ" /locus_tag="BSU_05070" /old_locus_tag="BSU05070" /label="yddQ gene" promotor_-35 514687..514691 /Source="Nicolas_upshift_promotors" /id="U393" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=2688 /SigmaFactorBS="agtcaaagagttaaaacacttttttttatcTATGTattcgaa cactgctgaTATTATACACTTAACTCTGTcgatctaagacaaataaaaaaagaaagtg a" /listShort="yddR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 514708..514727 /Source="Nicolas_upshift_promotors" /id="U393" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=2688 /SigmaFactorBS="agtcaaagagttaaaacacttttttttatcTATGTattcgaa cactgctgaTATTATACACTTAACTCTGTcgatctaagacaaataaaaaaagaaagtg a" /listShort="yddR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 514717 /Source="Nicolas_upshifts" /id="U393" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=2688 /SigmaFactorBS="agtcaaagagttaaaacacttttttttatcTATGTattcgaa cactgctgaTATTATACACTTAACTCTGTcgatctaagacaaataaaaaaagaaagtg a" /listShort="yddR" /GFF_Attribute="listLong" /label="upshifts" CDS 514767..515531 /gene="yddR" /locus_tag="BSU_05080" /old_locus_tag="BSU05080" /EC_number="3.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent hydrolase" /protein_id="NP_388389.1" /db_xref="EnsemblGenomes-Gn:BSU05080" /db_xref="EnsemblGenomes-Tr:CAB12315" /db_xref="GOA:P96655" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG12125" /db_xref="UniProtKB/Swiss-Prot:P96655" /translation="MNITQIRNATIVVKYANKKFLIDPMLAEKGTYATFPETIRQDLF NPLVSLPTSIDNILDGVDAVIVTHLHLDHFDDVAKNVLPKNIKMFVQNEADAKEVKAS GFKNVEVLHQDTVFEGIQLVKTKGEHGRGEELLNLMGDVCGLVFKHPSEKVLYVAGDT VWYDAIEDEIHTHQPEIIVVNGGDNQRLDLGSLIMGKEDIYEVHKAAPHAKIISVHME AVNHWTLSREELKNFSKEKGFSSNILVPEDGESYTF*" /label="yddR CDS" gene 514767..515531 /gene="yddR" /locus_tag="BSU_05080" /old_locus_tag="BSU05080" /label="yddR gene" CDS 515725..517035 /gene="yddS" /locus_tag="BSU_05090" /old_locus_tag="BSU05090" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388390.1" /db_xref="EnsemblGenomes-Gn:BSU05090" /db_xref="EnsemblGenomes-Tr:CAB12316" /db_xref="GOA:P96656" /db_xref="InterPro:IPR005828" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12126" /db_xref="UniProtKB/Swiss-Prot:P96656" /translation="MVMTKKDTNISTQQPLWLQGYIDSPEKQNQLYKKTLKILIFSQI FGGAGLGAGITVGALLAQDMIGSENVAGIPTALFTFGSAVAALLIGASSQRFGRRAGL AGGFLIGGLGAIGVIIAALINSVALLFVSLLIYGAGMASNLQVRYAGTDLANEKQRAT AASMALVSTTLGAVVGPNLVNTMGEFADSIGVPNLAGPFIMSGAAFIIAGIILLIFLR PDPLFVSTAIANAEKKDDKVQIGGSLKNPAIDKKGIMVGAVIMILAQLIMTAIMTMTP VHMGHHGHGLSEVGLVIGLHIAAMYLPSPLTGLLVDKFGRTTMAIASGATLLAAGLVA AIAPADSLSLLILALVLLGVGWNFGLLTGTALIIDSTHPSLRAKTQGTFDVLLALSGA AGGALSGMVVAHSSYTILSISGAVLSLLLIPVVIWYFRRIQEKA*" /label="yddS CDS" gene 515725..517035 /gene="yddS" /locus_tag="BSU_05090" /old_locus_tag="BSU05090" /label="yddS gene" S_feature 517058..517617 /Source="Nicolas_S_feature" /locus_tag="new_556002_556561" /HighExp="S8, C30, Cold, BMM, C90, GM 25, MG 15, M/G, LPh, S7" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S178" CDS 517618..517794 /gene="ydzM" /locus_tag="BSU_05099" /old_locus_tag="BSU05099" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="conserved phage protein of unknown function" /protein_id="YP_003097682.1" /db_xref="EnsemblGenomes-Gn:BSU05099" /db_xref="EnsemblGenomes-Tr:CAX52553" /db_xref="GOA:Q9K3A9" /db_xref="UniProtKB/Swiss-Prot:Q9K3A9" /translation="MNNKKNIFDIVMYIIFGVLSLFLVAKTDYGTGVLVFVAILYLAV IAYKIKQVFSNSDS*" /label="ydzM CDS" gene 517618..517794 /gene="ydzM" /locus_tag="BSU_05099" /old_locus_tag="BSU05099" /label="ydzM gene" CDS 517819..518505 /gene="yddT" /locus_tag="BSU_05100" /old_locus_tag="BSU05100" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative exported phage protein" /protein_id="NP_388391.1" /db_xref="EnsemblGenomes-Gn:BSU05100" /db_xref="EnsemblGenomes-Tr:CAB12317" /db_xref="SubtiList:BG12127" /db_xref="UniProtKB/Swiss-Prot:P96657" /translation="MRKKRVITCVMAASLTLGSLLPAGYASAKEDSKTTPSYEELALH YKMKSEKISSNGKLVEIEYVSGNETHKVQMNGNNHTVKVDGIEQKGLNFEYDENVAKR TNYENNNLKSNEFTTQAAKPKKGYHYVGTLSGHTKAAKNALSVTMSLVGIVPGLGWGS KAATILFSYWAKEQIPDAYYKYDLYEKGAMTDSWYQYATVQFFEDKAHKKKMGKPWTS TPAKVDLPNS*" /label="yddT CDS" gene 517819..518505 /gene="yddT" /locus_tag="BSU_05100" /old_locus_tag="BSU05100" /label="yddT gene" promotor_-35 518847..518851 /Source="Nicolas_upshift_promotors" /id="U394" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.383616383616384" /psig="0.999000999001" /xcortree=2778 /SigmaFactorBS="gaaaggtttaagattagatattgaaaaattttaTATATtttc aataaaatacTGGTACTATAATAAATGTATacagattgtatggagatgtaattaatta a" /listShort="ydzN, ydeA" /listLong="S179, cspC" /label="promotor_-35" promotor_-10 518866..518885 /Source="Nicolas_upshift_promotors" /id="U394" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.383616383616384" /psig="0.999000999001" /xcortree=2778 /SigmaFactorBS="gaaaggtttaagattagatattgaaaaattttaTATATtttc aataaaatacTGGTACTATAATAAATGTATacagattgtatggagatgtaattaatta a" /listShort="ydzN, ydeA" /listLong="S179, cspC" /label="promotor_-10" upshifts 518874 /Source="Nicolas_upshifts" /id="U394" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.383616383616384" /psig="0.999000999001" /xcortree=2778 /SigmaFactorBS="gaaaggtttaagattagatattgaaaaattttaTATATtttc aataaaatacTGGTACTATAATAAATGTATacagattgtatggagatgtaattaatta a" /listShort="ydzN, ydeA" /listLong="S179, cspC" /label="upshifts" Polymorphism join(518921,518923) /Source="geneious" /ID="SNP_BsDelta6_557866_557865" /Polymorphism_Type="Insertion (tandem repeat)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=0 /Amino_Acid_Change /CDS_Position /Change="(T)5 -> (T)6" /Codon_Change /Coverage=35 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides /Variant_Nucleotides="T" /Variant_P_Value="3.2e-123" /Variant_Raw_Frequency=35 /comment="ydzN_translation_signal_variant" /modified_by="User" / /label="Polymorphism_Delta6" CDS 518930..519115 /gene="ydzN" /locus_tag="BSU_05109" /old_locus_tag="BSU05109" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097683.1" /db_xref="EnsemblGenomes-Gn:BSU05109" /db_xref="EnsemblGenomes-Tr:CAX52554" /db_xref="GOA:C0H3V7" /db_xref="UniProtKB/Swiss-Prot:C0H3V7" /translation="MRWSKWFNVFCIVALGSIYGYKLFTNQEVSTTRLIIASVIVLWN IVGLFSKESVKQAQQAN*" /label="ydzN CDS" gene 518930..519115 /gene="ydzN" /locus_tag="BSU_05109" /old_locus_tag="BSU05109" /label="ydzN gene" downshifts 519114 /Source="Nicolas_upshifts" /id="D241" /incds=0 /nref=9 /ntot=125 /MaxReadThrough="3.39785" /MaxDrop="3.7067" /score="-6.31330934" /energy="-12.8" /TU="U394" /idTUdmin="U394" /TUdmin="-1068" /isTUend="FALSE" /label="downshifts" CDS 519465..520058 /gene="sufLC" /locus_tag="BSU_05110" /old_locus_tag="BSU05110" /experiment="publication(s) with functional evidences, PMID:24330391" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 24330391; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glyoxalase III homolog, deglycase" /protein_id="NP_388392.1" /db_xref="EnsemblGenomes-Gn:BSU05110" /db_xref="EnsemblGenomes-Tr:CAB12318" /db_xref="GOA:P96658" /db_xref="InterPro:IPR002818" /db_xref="InterPro:IPR029062" /db_xref="PDB:3F5D" /db_xref="SubtiList:BG12128" /db_xref="UniProtKB/Swiss-Prot:P96658" /translation="MKKALFLILDQYADWEGVYLASALNQREDWSVHTVSLDPIVSSI GGFKTSVDYIIGLEPANFNLLVMIGGDSWSNDNKKLLHFVKTAFQKNIPIAAICGAVD FLAKNGLLNNHSHTGNFVYLWKDYKQYKPISSFVEKQAVRDKNLVTANGTAPIEFTNL ILEMIDFDTPENIEKMMYMNRYGFYHFCDKYGNPFVD*" /label="sufLC CDS" gene 519465..520058 /gene="sufLC" /locus_tag="BSU_05110" /old_locus_tag="BSU05110" /label="sufLC gene" promotor_-35 520171..520178 /Source="Nicolas_upshift_promotors" /id="U395" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.561438561438561" /psig=1 /xcortree=3090 /SigmaFactorBS="aagtttaacaaataatgccatcaatattAATTTGCAgttatt tccgattCCTGATATAATAAAGAAGAAttatttttgttcggtgtaaaggatagtatga a" /listShort="S179, cspC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 520192..520211 /Source="Nicolas_upshift_promotors" /id="U395" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.561438561438561" /psig=1 /xcortree=3090 /SigmaFactorBS="aagtttaacaaataatgccatcaatattAATTTGCAgttatt tccgattCCTGATATAATAAAGAAGAAttatttttgttcggtgtaaaggatagtatga a" /listShort="S179, cspC" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 520203..520320 /Source="Nicolas_S_feature" /locus_tag="new_559146_559263" /HighExp="B60, LoTm, T5.0H, T3.30H, M9-stat, BI, BC, C90, T3.0H, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.999" /label="S179" upshifts 520203 /Source="Nicolas_upshifts" /id="U395" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.561438561438561" /psig=1 /xcortree=3090 /SigmaFactorBS="aagtttaacaaataatgccatcaatattAATTTGCAgttatt tccgattCCTGATATAATAAAGAAGAAttatttttgttcggtgtaaaggatagtatga a" /listShort="S179, cspC" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(520238) /Source="Nicolas_upshifts" /id="D242" /incds=0 /nref=10 /ntot=93 /MaxReadThrough="1.86628" /MaxDrop="4.19111" /score="25.1917407" /energy="-12.9" /TU="NA" /idTUdmin="U396" /TUdmin=328 /isTUend="FALSE" /label="downshifts" CDS 520321..520521 /gene="cspC" /locus_tag="BSU_05120" /old_locus_tag="BSU05120" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9379903, 9914312, 9920884, 10517332, 11591689, 12427936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9379903, 9914312, 9920884, 10517332, 11591689, 12427936; Product type f : factor" /codon_start=1 /transl_table=11 /product="cold-shock protein" /protein_id="NP_388393.1" /db_xref="EnsemblGenomes-Gn:BSU05120" /db_xref="EnsemblGenomes-Tr:CAB12319" /db_xref="GOA:P39158" /db_xref="InterPro:IPR002059" /db_xref="InterPro:IPR011129" /db_xref="InterPro:IPR012156" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR019844" /db_xref="SubtiList:BG11024" /db_xref="UniProtKB/Swiss-Prot:P39158" /translation="MEQGTVKWFNAEKGFGFIERENGDDVFVHFSAIQSDGFKSLDEG QKVSFDVEQGARGAQAANVQKA*" /label="cspC CDS" gene 520321..520521 /gene="cspC" /locus_tag="BSU_05120" /old_locus_tag="BSU05120" /label="cspC gene" S_feature complement(520419..521207) /Source="Nicolas_S_feature" /locus_tag="new_559362_560150_c" /HighExp="LoTm, B60, Cold, M9-stat, LPhT, B36, Sw, BC, S8, Salt" /AntisenseName="cspC" /AntisenseCor="0.39074308987975698" /AntisenseRegPval="-10.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S180" downshifts 520424 /Source="Nicolas_upshifts" /id="D243" /incds=1 /nref=19 /ntot=179 /MaxReadThrough="8.05368" /MaxDrop="3.4464" /score="27.3387234" /energy="-11.3" /TU="U395" /idTUdmin="U394" /TUdmin=242 /isTUend="FALSE" /label="downshifts" downshifts 520525 /Source="Nicolas_upshifts" /id="D244" /incds=0 /nref=65 /ntot=246 /MaxReadThrough="5.78621" /MaxDrop="5.83905" /score="27.3387234" /energy="-11.3" /TU="U395" /idTUdmin="U394" /TUdmin=343 /isTUend="FALSE" /label="downshifts" misc_RNA complement(520589..520667) /gene="sncZ" /locus_tag="BSU_misc_RNA_66" /product="putative small conserved untranslated RNA" /experiment="publication(s) with functional evidences, PMID:20525796" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20525796; Product type n: RNA" /label="sncZ RNA" gene complement(520589..520667) /gene="sncZ" /locus_tag="BSU_misc_RNA_66" /label="sncZ gene" CDS complement(521208..521669) /gene="cdnL" /locus_tag="BSU_05130" /old_locus_tag="BSU05130" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 26849219; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator for repair and outgrowth of heat damaged spores" /protein_id="NP_388394.1" /db_xref="EnsemblGenomes-Gn:BSU05130" /db_xref="EnsemblGenomes-Tr:CAB12320" /db_xref="InterPro:IPR003711" /db_xref="InterPro:IPR036101" /db_xref="SubtiList:BG12129" /db_xref="UniProtKB/Swiss-Prot:P96659" /translation="MFQIGDNIVYPMHGAGIIEAIEEKEFLEEKQQYYVIRMSISNMT VMIPTSKILSSNIRPVTDILALKHIMHIFQHGESDRLLPWKQRYKINTDKIKTGEIQE GAEVVRDLMRMKKEKALNASEKKMLDNAYEFLISELEVIKGITEKQIKSFG*" /label="cdnL CDS" gene complement(521208..521669) /gene="cdnL" /locus_tag="BSU_05130" /old_locus_tag="BSU05130" /label="cdnL gene" S_feature 521678..522223 /Source="Nicolas_S_feature" /locus_tag="new_560621_561166" /HighExp="Cold, G135, S8, G180, LoTm, S7, G150, HPh, Paraq, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S181" upshifts complement(521721) /Source="Nicolas_upshifts" /id="U396" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=427 /SigmaFactorBS="ttcaaaaaagtTATTGACAtcaaaaattcgatcaTGTTATTA TTAAAATTTTGAtattacacctccatatatggtaatcttaagaaggataccatatatg g" /listShort="ydeB, S180" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(521728..521747) /Source="Nicolas_upshift_promotors" /id="U396" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=427 /SigmaFactorBS="ttcaaaaaagtTATTGACAtcaaaaattcgatcaTGTTATTA TTAAAATTTTGAtattacacctccatatatggtaatcttaagaaggataccatatatg g" /listShort="ydeB, S180" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(521763..521770) /Source="Nicolas_upshift_promotors" /id="U396" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=427 /SigmaFactorBS="ttcaaaaaagtTATTGACAtcaaaaattcgatcaTGTTATTA TTAAAATTTTGAtattacacctccatatatggtaatcttaagaaggataccatatatg g" /listShort="ydeB, S180" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 522190 /Source="Nicolas_upshifts" /id="D245" /incds=0 /nref=7 /ntot=141 /MaxReadThrough="0.289110000000001" /MaxDrop="4.3701" /score="26.1823933" /energy="-9.5" /TU="NA" /idTUdmin="U395" /TUdmin=864 /isTUend="FALSE" /label="downshifts" CDS complement(522237..522473) /gene="ydzE" /locus_tag="BSU_05140" /old_locus_tag="BSU05140" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388395.1" /db_xref="EnsemblGenomes-Gn:BSU05140" /db_xref="EnsemblGenomes-Tr:CAB12321" /db_xref="GOA:O31493" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG12808" /db_xref="UniProtKB/Swiss-Prot:O31493" /translation="MYLGIVSTACAFLLWNHGLQLLNASSGGLFFFFQPLVGTLLGWI LLGEQIGGTFWIGSFLILSGVLLVIKEKEKEVKS*" /label="ydzE CDS" gene complement(522237..522473) /gene="ydzE" /locus_tag="BSU_05140" /old_locus_tag="BSU05140" /label="ydzE gene" CDS complement(522571..523446) /gene="ydeC" /locus_tag="BSU_05150" /old_locus_tag="BSU05150" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10704478; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (AraC/XylS family)" /protein_id="NP_388396.1" /db_xref="EnsemblGenomes-Gn:BSU05150" /db_xref="EnsemblGenomes-Tr:CAB12322" /db_xref="GOA:P96660" /db_xref="InterPro:IPR003313" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR018060" /db_xref="InterPro:IPR018062" /db_xref="InterPro:IPR020449" /db_xref="SubtiList:BG12130" /db_xref="UniProtKB/Swiss-Prot:P96660" /translation="MKNFVIDQNLKELTEHRTVELPVACYKTTINQNINGYIPLHWHD EIQFVLILKGIALFQINEEKIEVHEGDGLFINSGYLHMAEEKEGSDCTYICLNVSPHF VLSQELYSSYVQPYMFSTNLPYLFLAGNQQWAKNILDAVKKINQLIQQKTSLYEIDIT MQLTLMWKNLVVNGFQLEYDQSEMIKSHRMKQMLNWIHLHYVEKITLEDIAKAGQLSR SECCRYFKRMLNKTPLRYVMDYRIQKSLLLLQHPESNVTEVSYQVGFNSTSYFISKFQ QAMNMTPLSYKKMNS*" /label="ydeC CDS" gene complement(522571..523446) /gene="ydeC" /locus_tag="BSU_05150" /old_locus_tag="BSU05150" /label="ydeC gene" CDS 523559..524518 /gene="ydeD" /locus_tag="BSU_05160" /old_locus_tag="BSU05160" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388397.1" /db_xref="EnsemblGenomes-Gn:BSU05160" /db_xref="EnsemblGenomes-Tr:CAB12323" /db_xref="GOA:P96661" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG12131" /db_xref="UniProtKB/Swiss-Prot:P96661" /translation="MNTSNRRMGLFYVITGATCWGIGGTVAKKLFQEYQIDVNWLVTT RLLTAGMLLLMLQLFRKDRSQVIEVWKHKASAGQLLIFGLLGMLAVQYTYMASIQHGN AAVATLLQYLSPVIVIIYTLLRKQTVLTKQDIITVVLALVGCFFLLTNGSMSQLSVPA AAVVWGVLSGFAAAFYTLYAVGLLNKFDSLVVVGWAMIIGGFALGFIHPPWQLDFQRL TAEAYAYILFVILFGTMIAFWFFIKSLESLSPKETSLLGSLEPLSAVVTTVVWLKAPF GSFQWIGAICIIGITLILALHKEPSMESEKSILKIRNHANRDI*" /label="ydeD CDS" gene 523559..524518 /gene="ydeD" /locus_tag="BSU_05160" /old_locus_tag="BSU05160" /label="ydeD gene" upshifts complement(523580) /Source="Nicolas_upshifts" /id="U397" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.555444555444555" /psig="0.808191808191808" /xcortree=1969 /SigmaFactorBS="tggctactgtgcctccaatcccccaacatgtcgccccTGTGA TAACATAGAACAATCccattcttctattggaagtattcatacatgactcctcactaat a" /listShort="ydeC" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(523584..523603) /Source="Nicolas_upshift_promotors" /id="U397" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.555444555444555" /psig="0.808191808191808" /xcortree=1969 /SigmaFactorBS="tggctactgtgcctccaatcccccaacatgtcgccccTGTGA TAACATAGAACAATCccattcttctattggaagtattcatacatgactcctcactaat a" /listShort="ydeC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(524671..525543) /gene="ydeE" /locus_tag="BSU_05170" /old_locus_tag="BSU05170" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (AraC/XylS family)" /protein_id="NP_388398.1" /db_xref="EnsemblGenomes-Gn:BSU05170" /db_xref="EnsemblGenomes-Tr:CAB12324" /db_xref="GOA:P96662" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR010499" /db_xref="InterPro:IPR011256" /db_xref="InterPro:IPR018060" /db_xref="InterPro:IPR018062" /db_xref="InterPro:IPR020449" /db_xref="InterPro:IPR029442" /db_xref="SubtiList:BG12132" /db_xref="UniProtKB/Swiss-Prot:P96662" /translation="MDLLKSMNRALKYIEENLTNDIDFQEAAKLAFCSEYHFKRMFSF LAGISLSEYIRRRRLTLAAFELKDSNVKVIDIAIKYGYNSPDSFARAFQNLHGINPSK ARFNGHSLKAYPRMTFQLTIKGGNEMNYRIEEKEAFRIVGIKKRVPIIFKGINPEIAS MWESLDEKAINKLKELSNVAPSGLISASTNFSEGRTEENGELDHYIGAATTKRCPDNF SRLEVPASTWAVFESIGPFPDTLQEVWGRIYSEWFPSSNYEQIEGPEILWNEHKDVTS PSFKSEIWIPITKK*" /label="ydeE CDS" gene complement(524671..525543) /gene="ydeE" /locus_tag="BSU_05170" /old_locus_tag="BSU05170" /label="ydeE gene" promotor_-10 complement(525636..525641) /Source="Nicolas_upshift_promotors" /id="U398" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.380619380619381" /psig="0.432567432567433" /xcortree=1464 /SigmaFactorBS="cttttattgatgcctttttatgaacagcatgcttcaataaaa cctgtacaaatacaagtgaatcACtTACTTTatttcatataagtcatcctgcaaaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(525643..525644) /Source="Nicolas_upshift_promotors" /id="U398" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.380619380619381" /psig="0.432567432567433" /xcortree=1464 /SigmaFactorBS="cttttattgatgcctttttatgaacagcatgcttcaataaaa cctgtacaaatacaagtgaatcACtTACTTTatttcatataagtcatcctgcaaaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(525648) /Source="Nicolas_upshifts" /id="U398" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.380619380619381" /psig="0.432567432567433" /xcortree=1464 /SigmaFactorBS="cttttattgatgcctttttatgaacagcatgcttcaataaaa cctgtacaaatacaagtgaatcACtTACTTTatttcatataagtcatcctgcaaaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 525717..525723 /Source="Nicolas_upshift_promotors" /id="U399" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.408591408591409" /psig="0.98101898101898" /xcortree=1860 /SigmaFactorBS="attgaagcatgctgttcataaaaaggcatcaataaaagaaag ttatAATTGTCttataaacggcacATTCATATAATTGAGTGAAAaaggatgcgtatca t" /listShort="ydeF" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 525731 /Source="Nicolas_upshifts" /id="U399" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.408591408591409" /psig="0.98101898101898" /xcortree=1860 /SigmaFactorBS="attgaagcatgctgttcataaaaaggcatcaataaaagaaag ttatAATTGTCttataaacggcacATTCATATAATTGAGTGAAAaaggatgcgtatca t" /listShort="ydeF" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 525737..525756 /Source="Nicolas_upshift_promotors" /id="U399" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.408591408591409" /psig="0.98101898101898" /xcortree=1860 /SigmaFactorBS="attgaagcatgctgttcataaaaaggcatcaataaaagaaag ttatAATTGTCttataaacggcacATTCATATAATTGAGTGAAAaaggatgcgtatca t" /listShort="ydeF" /GFF_Attribute="listLong" /label="promotor_-10" CDS 525770..527158 /gene="ydeF" /locus_tag="BSU_05180" /old_locus_tag="BSU05180" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15223311, 28348215; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative PLP-dependent transcriptional regulator" /protein_id="NP_388399.2" /db_xref="EnsemblGenomes-Gn:BSU05180" /db_xref="EnsemblGenomes-Tr:CAB12325" /db_xref="GOA:P96663" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12133" /db_xref="UniProtKB/Swiss-Prot:P96663" /translation="MPINSFENYPMSWKPSIDKAEKPIYKALAGQLEQDILNGVLLPG TKLPPQRELADYLDLNVSTISKAFKVCELKGLLSATVGSGTFVSYDALSNAYLLEDTK PTHLIEMGAILPDHASYEPLLYQLKNMVHEEDYEKWFSYGRAGESLWQKDAAVKLIQR GGFETSVDHILFANGGQNAIAATLASLCKPGDRIGVDHHTYPGLKTVASLLSVQIVPI KSENDEMSPESLEYACKNENIKGLYLIPDYHNPTTSFMSVENRRMVADIVKKYNLFVI EDASYHLLNKNPLPALASFAPQQVIHIASLSKSLAPGLRLAYVAVPRQYKEPISKALY NLNITVSPLLAELTARTIVSNQFEVLIESHREQTIRRNQLVNRYVAGYTCLGVETGIF RWLLLPGKMSGAEFEELAARLGVQVYAAERFVVGNSCPERAVRVSVCAPKTLEELEQG LMILRRLLDDLT*" /label="ydeF CDS" gene 525770..527158 /gene="ydeF" /locus_tag="BSU_05180" /old_locus_tag="BSU05180" /label="ydeF gene" downshifts 527134 /Source="Nicolas_upshifts" /id="D246" /incds=0 /nref=2 /ntot=61 /MaxReadThrough="0.91547" /MaxDrop="3.65963" /score="12.298375" /energy="-12.2" /TU="NA" /idTUdmin="U399" /TUdmin=176 /isTUend="FALSE" /label="downshifts" CDS 527268..528560 /gene="ydeG" /locus_tag="BSU_05190" /old_locus_tag="BSU05190" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388400.1" /db_xref="EnsemblGenomes-Gn:BSU05190" /db_xref="EnsemblGenomes-Tr:CAB12326" /db_xref="GOA:P96664" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12134" /db_xref="UniProtKB/Swiss-Prot:P96664" /translation="MMLDKDSVKAIDVQTASLQSYISSPEKQKSLYKRTLFVVSISQI FGGAGLAAGVTVGALIAQQMLGTDAFAGLPSALFTLGSAGSALIVGRLSQRYGRRTGL SAGFMIGGLGAIGVIMAAIINSIFLLFISLLIYGAGTATNLQARYAGTDLANHKQRAT AVSITMVFTTFGAVAGPSLVNVMGDFALSIGVPSLAGPFILAAAAYMLAGVVLFIMLR PDPLVIARTIEAANEEPGDKGHLAATEHTENKKGIIVGATVMVLTQIVMVAIMTMTPV HMRHHGHDLGAVGLVIGFHIGAMYLPSLVTGVLVDRLGRTAMAISSGTTLLLAGVIAA FAPGESMILLVIALSLLGLGWNFGLISGTALIVDSTDTATRAKTQGTVDVLIALSGAA GGALSGMIVAGSSYLALSLIGGILSLLLIPVVVWSRGR*" /label="ydeG CDS" gene 527268..528560 /gene="ydeG" /locus_tag="BSU_05190" /old_locus_tag="BSU05190" /label="ydeG gene" promotor_-35 528569..528575 /Source="Nicolas_upshift_promotors" /id="U400" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.737262737262737" /psig=1 /xcortree=2927 /SigmaFactorBS="gtggtatggtctaggggccgctaaagggtaggATTGTTTaat ttacattaattTGTTATATTGTTAGATAAAGtatattgcagcatctaatattctaacg a" /listShort="S182, ydeH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 528590..528609 /Source="Nicolas_upshift_promotors" /id="U400" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.737262737262737" /psig=1 /xcortree=2927 /SigmaFactorBS="gtggtatggtctaggggccgctaaagggtaggATTGTTTaat ttacattaattTGTTATATTGTTAGATAAAGtatattgcagcatctaatattctaacg a" /listShort="S182, ydeH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 528597 /Source="Nicolas_upshifts" /id="U400" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.737262737262737" /psig=1 /xcortree=2927 /SigmaFactorBS="gtggtatggtctaggggccgctaaagggtaggATTGTTTaat ttacattaattTGTTATATTGTTAGATAAAGtatattgcagcatctaatattctaacg a" /listShort="S182, ydeH" /GFF_Attribute="listLong" /label="upshifts" S_feature 528608..528718 /Source="Nicolas_S_feature" /locus_tag="new_567551_567661" /HighExp="LoTm, T4.0H, T3.30H, T2.30H, T3.0H, T2.0H, T1.30H, T5.0H, T1.0H, T-0.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S182" CDS 528719..529165 /gene="ydeH" /locus_tag="BSU_05200" /old_locus_tag="BSU05200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388401.1" /db_xref="EnsemblGenomes-Gn:BSU05200" /db_xref="EnsemblGenomes-Tr:CAB12327" /db_xref="GOA:P96665" /db_xref="SubtiList:BG12135" /db_xref="UniProtKB/Swiss-Prot:P96665" /translation="MNHIKWLSDLKKAGLLALGKGVITLLKRFSLVIVTLMMSIVVVL AAAKESPGDHVISFDEPIILMISIGIVVFLLIPPLVMSFFGNLVVRIISGVYQCFIVF TFLGLIPIGFLIPNGFLTILVSIAGTLVSIASVAVTLCIGKNKKDI*" /label="ydeH CDS" gene 528719..529165 /gene="ydeH" /locus_tag="BSU_05200" /old_locus_tag="BSU05200" /label="ydeH gene" downshifts 529194 /Source="Nicolas_upshifts" /id="D247" /incds=0 /nref=200 /ntot=251 /MaxReadThrough="2.56495" /MaxDrop="6.50538" /score="-1.7193297" /energy="-4.5" /TU="NA" /idTUdmin="U400" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" promotor_-35 529245..529252 /Source="Nicolas_upshift_promotors" /id="U401" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.921078921078921" /psig="0.99100899100899" /xcortree=2390 /SigmaFactorBS="tacaaaaagagaaggcttgtgggccttctttttttgtTGTTG CATcatccccactttgaGCTTAATCTATTGAATAATAagagaaggaacctatagaaga a" /listShort="ydeI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 529267..529286 /Source="Nicolas_upshift_promotors" /id="U401" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.921078921078921" /psig="0.99100899100899" /xcortree=2390 /SigmaFactorBS="tacaaaaagagaaggcttgtgggccttctttttttgtTGTTG CATcatccccactttgaGCTTAATCTATTGAATAATAagagaaggaacctatagaaga a" /listShort="ydeI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 529268 /Source="Nicolas_upshifts" /id="U401" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.921078921078921" /psig="0.99100899100899" /xcortree=2390 /SigmaFactorBS="tacaaaaagagaaggcttgtgggccttctttttttgtTGTTG CATcatccccactttgaGCTTAATCTATTGAATAATAagagaaggaacctatagaaga a" /listShort="ydeI" /GFF_Attribute="listLong" /label="upshifts" CDS 529402..529995 /gene="ydeI" /locus_tag="BSU_05210" /old_locus_tag="BSU05210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16390439" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388402.1" /db_xref="EnsemblGenomes-Gn:BSU05210" /db_xref="EnsemblGenomes-Tr:CAB12328" /db_xref="InterPro:IPR014922" /db_xref="InterPro:IPR016786" /db_xref="SubtiList:BG12136" /db_xref="UniProtKB/Swiss-Prot:P96666" /translation="MTNSRTNPKVDEFLSKAKKWKEEFEKLRTIILDCELTEDFKWMH PCYTYHNKNIVLIHGFKEYCALLFHKGVLLQDTDGILIQQTENVQAARQIRFTNVQEI NELENILKAYIHEAIEVEKAGLKVDVNKNIELNIPEELQNKFDEIPALKIAFEALTPG RQRAYTLYFSQAKQSKTRESRVEKYVQKILDGKGLKD*" /label="ydeI CDS" gene 529402..529995 /gene="ydeI" /locus_tag="BSU_05210" /old_locus_tag="BSU05210" /label="ydeI gene" downshifts 530038 /Source="Nicolas_upshifts" /id="D248" /incds=0 /nref=2 /ntot=40 /MaxReadThrough="1.63432" /MaxDrop="2.96785" /score="2.93671425" /energy="-6.9" /TU="NA" /idTUdmin="U401" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(530114) /Source="Nicolas_upshifts" /id="D249" /incds=0 /nref=1 /ntot=64 /MaxReadThrough="2.19009" /MaxDrop="2.9369" /score="-1.28013562" /energy="-6.9" /TU="NA" /idTUdmin="U403" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 530127..530134 /Source="Nicolas_upshift_promotors" /id="U402" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.707292707292707" /psig="0.996003996003996" /xcortree=378 /SigmaFactorBS="tcttaggacaacattcacttactgctgaaatgcttctaaCAT TGTATgccactagacagcgTTATAAAATATTAATGCAACacctagaaatctatccaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 530148 /Source="Nicolas_upshifts" /id="U402" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.707292707292707" /psig="0.996003996003996" /xcortree=378 /SigmaFactorBS="tcttaggacaacattcacttactgctgaaatgcttctaaCAT TGTATgccactagacagcgTTATAAAATATTAATGCAACacctagaaatctatccaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 530149..530168 /Source="Nicolas_upshift_promotors" /id="U402" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.707292707292707" /psig="0.996003996003996" /xcortree=378 /SigmaFactorBS="tcttaggacaacattcacttactgctgaaatgcttctaaCAT TGTATgccactagacagcgTTATAAAATATTAATGCAACacctagaaatctatccaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(530347..531006) /gene="ydeJ" /locus_tag="BSU_05220" /old_locus_tag="BSU05220" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_388403.1" /db_xref="EnsemblGenomes-Gn:BSU05220" /db_xref="EnsemblGenomes-Tr:CAB12329" /db_xref="GOA:P96667" /db_xref="SubtiList:BG12137" /db_xref="UniProtKB/Swiss-Prot:P96667" /translation="MKKRRKICYCNTALLLMILLAGCTDSKDGEAQQPSNQASAVQTD EKHTEPEESTKIRKDEAEPITESEESATKAANDTSSAEEKSKEDNVLAAYSSEKIEYA RVWLQLGPNQEIDELNVRHIAAGEPINPNDDTSASYPENVTQLAGSRLVDGSVTYHGN GDGTIHVYNVPLRWDSADDIEKGVMREVTESIIKNRKTVYVDTGDDEKIKRLIDIMMI H*" /label="ydeJ CDS" gene complement(530347..531006) /gene="ydeJ" /locus_tag="BSU_05220" /old_locus_tag="BSU05220" /label="ydeJ gene" promotor_-10 complement(531055..531074) /Source="Nicolas_upshift_promotors" /id="U403" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.987012987012987" /psig="0.997002997002997" /xcortree=3174 /SigmaFactorBS="agatcgtttcctcttcttaaacagttttcaaTATCATcctat ctattcCATGGTAATATTTAGATACAtaaacttatatatgaagctgacctgaattaat a" /listShort="ydeJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(531062) /Source="Nicolas_upshifts" /id="U403" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.987012987012987" /psig="0.997002997002997" /xcortree=3174 /SigmaFactorBS="agatcgtttcctcttcttaaacagttttcaaTATCATcctat ctattcCATGGTAATATTTAGATACAtaaacttatatatgaagctgacctgaattaat a" /listShort="ydeJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(531086..531091) /Source="Nicolas_upshift_promotors" /id="U403" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.987012987012987" /psig="0.997002997002997" /xcortree=3174 /SigmaFactorBS="agatcgtttcctcttcttaaacagttttcaaTATCATcctat ctattcCATGGTAATATTTAGATACAtaaacttatatatgaagctgacctgaattaat a" /listShort="ydeJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(531428..532291) /gene="ydeK" /locus_tag="BSU_05230" /old_locus_tag="BSU05230" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_388404.1" /db_xref="EnsemblGenomes-Gn:BSU05230" /db_xref="EnsemblGenomes-Tr:CAB12330" /db_xref="GOA:P96668" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG12138" /db_xref="UniProtKB/Swiss-Prot:P96668" /translation="MNKTTNGWINGFIGVLIFSGSLPATRLAVSDFDPLFLTVCRAAI AGVLAGGLLLIFRQQHPAKRDLISLLVVAFGVVIGFPLLTALALQHVTSAHAIVFIGL LPLATAVFGVLRGGERPRPVFWIFSAAGSLLVAGFALIQGGGSSPLGDAYMLASIVVC GLGYAEGAKLSRRLGNWQVISWALVLSLPLMLPLSFFFTPDSWSAIGVPALLSLAYVS LFSMLIGFVFWYRGLAQGGIAAVGQLQLLQPFFGLLLASVILHEKVGWALVAVNIAVI MCVAAARRFAK*" /label="ydeK CDS" gene complement(531428..532291) /gene="ydeK" /locus_tag="BSU_05230" /old_locus_tag="BSU05230" /label="ydeK gene" promotor_-35 532334..532340 /Source="Nicolas_upshift_promotors" /id="U404" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.548451548451548" /psig="0.97002997002997" /xcortree=639 /SigmaFactorBS="ctttcttgttcattgtctgtatttTCTTAACaaaaccagcag ctaAGGATTACAATGACTATAAActggaattggccttttataaacagccagttttcat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 532355..532374 /Source="Nicolas_upshift_promotors" /id="U404" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.548451548451548" /psig="0.97002997002997" /xcortree=639 /SigmaFactorBS="ctttcttgttcattgtctgtatttTCTTAACaaaaccagcag ctaAGGATTACAATGACTATAAActggaattggccttttataaacagccagttttcat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(532356..532375) /Source="Nicolas_upshift_promotors" /id="U405" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.811188811188811" /psig="0.997002997002997" /xcortree=412 /SigmaFactorBS="cgttgttctcctaactggtatgcatttttttatgaaaactgg cTGTTTATAaaaggccaattccaGTTTATAGTCATTGTAATCCttagctgctggtttt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 532370 /Source="Nicolas_upshifts" /id="U404" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.548451548451548" /psig="0.97002997002997" /xcortree=639 /SigmaFactorBS="ctttcttgttcattgtctgtatttTCTTAACaaaaccagcag ctaAGGATTACAATGACTATAAActggaattggccttttataaacagccagttttcat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(532380) /Source="Nicolas_upshifts" /id="U405" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.811188811188811" /psig="0.997002997002997" /xcortree=412 /SigmaFactorBS="cgttgttctcctaactggtatgcatttttttatgaaaactgg cTGTTTATAaaaggccaattccaGTTTATAGTCATTGTAATCCttagctgctggtttt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(532390..532397) /Source="Nicolas_upshift_promotors" /id="U405" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.811188811188811" /psig="0.997002997002997" /xcortree=412 /SigmaFactorBS="cgttgttctcctaactggtatgcatttttttatgaaaactgg cTGTTTATAaaaggccaattccaGTTTATAGTCATTGTAATCCttagctgctggtttt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 532446..533837 /gene="ydeL" /locus_tag="BSU_05240" /old_locus_tag="BSU05240" /function="16.3: Control" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15223311, 28348215; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative PLP-dependent transcriptional regulator" /protein_id="NP_388405.1" /db_xref="EnsemblGenomes-Gn:BSU05240" /db_xref="EnsemblGenomes-Tr:CAB12331" /db_xref="GOA:P96669" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12139" /db_xref="UniProtKB/Swiss-Prot:P96669" /translation="MDITPFLNRTLDIPLYQQLYRYFKENMHRGRIQKGMKLPSKRLL ANQLSISQTTVERAYEQLAAEGYIVSKPRSGWFADYHDSDFAYDRMPSTTPIQQEAEE NKQWIDFHYGNVDSSYFPFSAWRKSMVNSLDQYGHELYRPGHVLGEFELRTLIAEYLY QSRGVHCGPEQVIIGAGNPILLQILCQVFEPNISIGYEDPGYPRARKIFEANRMNIVP IPVDDEGICIQKIKEQQPNLVYVTPSHQFTLGTIMTINRRIQLLKWAAENQSFIIEDD YDGEFRYTGQPVPSLQGLDQHNRVIYMGTFSKSLLPSLRISYMILPSPLLKKGHEITS LYKQTVSCHSQLTLAEFIKNGEWQKHINRMRKLYRKKRAIVLEAVQRELGEHVRIRGE NSGLRILLDVYLPFGEKELIEKAKKHGVKIYPVSLSYQHHPPTKTVSLGFAGVSESDI REGIKKLKAAWKI*" /label="ydeL CDS" gene 532446..533837 /gene="ydeL" /locus_tag="BSU_05240" /old_locus_tag="BSU05240" /label="ydeL gene" promotor_-35 533965..533972 /Source="Nicolas_upshift_promotors" /id="U406" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2260 /SigmaFactorBS="gatacgtctgtttagcgaaaaacagaatTTTTTATTtgctcc tcacAGTGCTAAAATAAACAAAATagacaattgaaaaaatagaggtgtaagaatgaag t" /listShort="ydeM, S183" /listLong="ydeO" /label="promotor_-35" promotor_-10 533983..534002 /Source="Nicolas_upshift_promotors" /id="U406" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2260 /SigmaFactorBS="gatacgtctgtttagcgaaaaacagaatTTTTTATTtgctcc tcacAGTGCTAAAATAAACAAAATagacaattgaaaaaatagaggtgtaagaatgaag t" /listShort="ydeM, S183" /listLong="ydeO" /label="promotor_-10" upshifts 533997 /Source="Nicolas_upshifts" /id="U406" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2260 /SigmaFactorBS="gatacgtctgtttagcgaaaaacagaatTTTTTATTtgctcc tcacAGTGCTAAAATAAACAAAATagacaattgaaaaaatagaggtgtaagaatgaag t" /listShort="ydeM, S183" /listLong="ydeO" /label="upshifts" CDS 534031..534456 /gene="ydeM" /locus_tag="BSU_05250" /old_locus_tag="BSU05250" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 1556068, 26349822; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dehydratase" /protein_id="NP_388406.1" /db_xref="EnsemblGenomes-Gn:BSU05250" /db_xref="EnsemblGenomes-Tr:CAB12332" /db_xref="InterPro:IPR002539" /db_xref="InterPro:IPR029069" /db_xref="SubtiList:BG12140" /db_xref="UniProtKB/Swiss-Prot:P96670" /translation="MKLDEFTIGQVFKTKSLKVSKDDIMRFAGEFDPQYMHVDEEKAS KGRFNGIIASGIQTLAISFKLWIEEGFYGDDIIAGTEMNHMTFIKPVYPDDELFTIVE VLDKQPKRNELGILTVLLSTYNQKEVKVFEGELSVLIKR*" /label="ydeM CDS" gene 534031..534456 /gene="ydeM" /locus_tag="BSU_05250" /old_locus_tag="BSU05250" /label="ydeM gene" S_feature 534457..535711 /Source="Nicolas_S_feature" /locus_tag="new_573400_574654" /HighExp="G135, H2O2, G150, HiOs, G180, Cold, Paraq, UNK1, MG 15, LBGexp" /AntisenseName="ydeN" /AntisenseCor="0.40423774227585801" /AntisenseRegPval="-11.3" /CDS_PredictionProba="0.127641" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S183" CDS complement(534509..535081) /gene="ydeN" /locus_tag="BSU_05260" /old_locus_tag="BSU05260" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15159570; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative alpha/beta hydrolase" /protein_id="NP_388407.1" /db_xref="EnsemblGenomes-Gn:BSU05260" /db_xref="EnsemblGenomes-Tr:CAB12333" /db_xref="GOA:P96671" /db_xref="InterPro:IPR010662" /db_xref="InterPro:IPR029058" /db_xref="PDB:1UXO" /db_xref="SubtiList:BG12141" /db_xref="UniProtKB/Swiss-Prot:P96671" /translation="MTKQVYIIHGYRASSTNHWFPWLKKRLLADGVQADILNMPNPLQ PRLEDWLDTLSLYQHTLHENTYLVAHSLGCPAILRFLEHLQLRKQLGGIILVSGFAKS LPTLQMLDEFTQGSFDHQKIIESAKHRAVIASKDDQIVPFSFSKDLAQQIDAALYEVQ HGGHFLEDEGFTSLPIVYDVLTSYFSKETR*" /label="ydeN CDS" gene complement(534509..535081) /gene="ydeN" /locus_tag="BSU_05260" /old_locus_tag="BSU05260" /label="ydeN gene" downshifts complement(534514) /Source="Nicolas_upshifts" /id="D250" /incds=0 /nref=16 /ntot=160 /MaxReadThrough="1.96868" /MaxDrop="3.80195" /score="2.50673989" /energy="-11.3" /TU="NA" /idTUdmin="U407" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(535082..535162) /Source="Nicolas_S_feature" /locus_tag="new_574025_574105_c" /HighExp="dia15, dia5, Diami, Etha, LPhT, Lbtran, Heat, H2O2, Sw, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.955" /TUlongSig="NA" /TUlongPSig="NA" /label="S184" CDS complement(535163..535492) /gene="ydzF" /locus_tag="BSU_05270" /old_locus_tag="BSU05270" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_388408.1" /db_xref="EnsemblGenomes-Gn:BSU05270" /db_xref="EnsemblGenomes-Tr:CAB12334" /db_xref="GOA:O31494" /db_xref="InterPro:IPR002577" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12809" /db_xref="UniProtKB/Swiss-Prot:O31494" /translation="MNSLCRSKQAPFEYTLSLIGGKWKMRILYELGCEKTMRYGELKR AMPFITHKMLSAQLKELQTDGLIHRSEVSHTPLKVEYSLSDRGRSLYPLIDEMCKWGM AQGGPHM*" /label="ydzF CDS" gene complement(535163..535492) /gene="ydzF" /locus_tag="BSU_05270" /old_locus_tag="BSU05270" /label="ydzF gene" misc_feature complement(535509..535528) /Source="Nicolas_upshift_promotors" /id="U407" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.416583416583417" /psig="0.955044955044955" /xcortree=1959 /SigmaFactorBS="cctttcacttcagatcgtgaatcgccctcaaacttcaacacc gaaaatcctaatttatTCTGATATGATACTTAAAAAaggaggtttgattacaatgaat a" /listShort="ydzF, S184, ydeN" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(535526) /Source="Nicolas_upshifts" /id="U407" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.416583416583417" /psig="0.955044955044955" /xcortree=1959 /SigmaFactorBS="cctttcacttcagatcgtgaatcgccctcaaacttcaacacc gaaaatcctaatttatTCTGATATGATACTTAAAAAaggaggtttgattacaatgaat a" /listShort="ydzF, S184, ydeN" /GFF_Attribute="listLong" /label="upshifts" misc_feature 535700..535719 /Source="Nicolas_upshift_promotors" /id="U408" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.78021978021978" /psig=1 /xcortree=2345 /SigmaFactorBS="agttactttatttaaaaaaacgcatgtttttagctgaaaata tctatTATGGTATATTTAAATATAAagaaatatttgagaaatgaggaatggtatgaat a" /listShort="ydeO" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 535713 /Source="Nicolas_upshifts" /id="U408" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.78021978021978" /psig=1 /xcortree=2345 /SigmaFactorBS="agttactttatttaaaaaaacgcatgtttttagctgaaaata tctatTATGGTATATTTAAATATAAagaaatatttgagaaatgaggaatggtatgaat a" /listShort="ydeO" /GFF_Attribute="listLong" /label="upshifts" CDS 535747..536619 /gene="ydeO" /locus_tag="BSU_05280" /old_locus_tag="BSU05280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388409.1" /db_xref="EnsemblGenomes-Gn:BSU05280" /db_xref="EnsemblGenomes-Tr:CAB12335" /db_xref="GOA:P96672" /db_xref="InterPro:IPR003740" /db_xref="InterPro:IPR019264" /db_xref="SubtiList:BG12142" /db_xref="UniProtKB/Swiss-Prot:P96672" /translation="MNTPKKHKKFKAKMILQIIMVIIGGIIAAYGLETVLIPNSVSDG GVTGLSIVGSQLFNLPLGILIAVINIPFVWLGYKQIGKSFALLSIIGIVSLAAGTSFF HHTPAIIEGDTLLITVVGGIILGFGMGLALRNGGALDGIDMLAVLLSRKLPFGTSDLI LFLNLFVFIFVSTVFGLQGALLSVIAYYIASKVIHVVEEGLSGSKTFQIITTQPELMV ETIRDQLGRSATYKEAYGGFSHEKFKEITCVINRLEETKLKEIINDIDKTAFVTVYDV AEVKGSNFRNLNHH*" /label="ydeO CDS" gene 535747..536619 /gene="ydeO" /locus_tag="BSU_05280" /old_locus_tag="BSU05280" /label="ydeO gene" downshifts 536506 /Source="Nicolas_upshifts" /id="D251" /incds=1 /nref=7 /ntot=181 /MaxReadThrough="3.84278" /MaxDrop="2.68681" /score="15.0132064" /energy="-12.2" /TU="U408" /idTUdmin="U408" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" downshifts 536704 /Source="Nicolas_upshifts" /id="D252" /incds=0 /nref=54 /ntot=208 /MaxReadThrough="1.19842" /MaxDrop="3.77294" /score="15.0132064" /energy="-12.2" /TU="NA" /idTUdmin="U408" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(536769..537155) /gene="ydeP" /locus_tag="BSU_05290" /old_locus_tag="BSU05290" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_388410.1" /db_xref="EnsemblGenomes-Gn:BSU05290" /db_xref="EnsemblGenomes-Tr:CAB12336" /db_xref="GOA:P96673" /db_xref="InterPro:IPR002577" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12143" /db_xref="UniProtKB/Swiss-Prot:P96673" /translation="MRNRKLGIDYSSDDFEGCPVETTLDIIGGKWKGILLYHLIDGKK RFNEFRKLYPKITQRMLTLQLRELERDGVIHREVYKQVPPKVEYSLTEFGRTLEPVIL HMKDWGEKYKDRIDKLEAARKAEDKI*" /label="ydeP CDS" gene complement(536769..537155) /gene="ydeP" /locus_tag="BSU_05290" /old_locus_tag="BSU05290" /label="ydeP gene" downshifts complement(536781) /Source="Nicolas_upshifts" /id="D253" /incds=0 /nref=29 /ntot=191 /MaxReadThrough="0.85093" /MaxDrop="4.4837" /score="-9.3516261" /energy="-12.9" /TU="NA" /idTUdmin="U409" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" S_feature complement(537156..537220) /Source="Nicolas_S_feature" /locus_tag="new_576099_576163_c" /HighExp="Diami, dia5, Salt, dia15, Etha, Heat, G180, HiOs, LBGexp, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S185" promotor_-35 537208..537215 /Source="Nicolas_upshift_promotors" /id="U410" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.67032967032967" /psig="0.936063936063936" /xcortree=1790 /SigmaFactorBS="agtatactttttgatactatatacattcaatgtgcgTACTTT TTatattttaatataCATCATATAATGATGTCACAtctaaggaatgaaaggaatggat c" /listShort="ydeQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(537209..537228) /Source="Nicolas_upshift_promotors" /id="U409" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.568431568431568" /psig="0.999000999001" /xcortree=1896 /SigmaFactorBS="gttttcatatgatccattcctttcattccttaGATGTGACat cattatatgatgTATATTAAAATATAAAAAGTacgcacattgaatgtatatagtatca a" /listShort="S185, ydeP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(537222) /Source="Nicolas_upshifts" /id="U409" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.568431568431568" /psig="0.999000999001" /xcortree=1896 /SigmaFactorBS="gttttcatatgatccattcctttcattccttaGATGTGACat cattatatgatgTATATTAAAATATAAAAAGTacgcacattgaatgtatatagtatca a" /listShort="S185, ydeP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 537229..537248 /Source="Nicolas_upshift_promotors" /id="U410" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.67032967032967" /psig="0.936063936063936" /xcortree=1790 /SigmaFactorBS="agtatactttttgatactatatacattcaatgtgcgTACTTT TTatattttaatataCATCATATAATGATGTCACAtctaaggaatgaaaggaatggat c" /listShort="ydeQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 537232 /Source="Nicolas_upshifts" /id="U410" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.67032967032967" /psig="0.936063936063936" /xcortree=1790 /SigmaFactorBS="agtatactttttgatactatatacattcaatgtgcgTACTTT TTatattttaatataCATCATATAATGATGTCACAtctaaggaatgaaaggaatggat c" /listShort="ydeQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(537243..537250) /Source="Nicolas_upshift_promotors" /id="U409" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.568431568431568" /psig="0.999000999001" /xcortree=1896 /SigmaFactorBS="gttttcatatgatccattcctttcattccttaGATGTGACat cattatatgatgTATATTAAAATATAAAAAGTacgcacattgaatgtatatagtatca a" /listShort="S185, ydeP" /GFF_Attribute="listLong" /label="promotor_-35" CDS 537266..537859 /gene="ydeQ" /locus_tag="BSU_05300" /old_locus_tag="BSU05300" /EC_number="1.6.99.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NAD(P)H oxidoreductase involved in regulating potassium efflux" /protein_id="NP_388411.1" /db_xref="EnsemblGenomes-Gn:BSU05300" /db_xref="EnsemblGenomes-Tr:CAB12337" /db_xref="GOA:P96674" /db_xref="InterPro:IPR003680" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG12144" /db_xref="UniProtKB/Swiss-Prot:P96674" /translation="MDHMKTLVLVVHPNIESSRINKKWKEAVLSEPDVTVHDLYEKYR DQPIDVEFEQQQLLAHDRIVFQFPLYWYSSPPLLKQWFDEVFTFGWAHGPGGNKLKGK EWVTAMSIGSPEHSYQAGGYNLFSISELTKPFQASAHLVGMTYLPSFAEYRANTISDQ EIAESANRYVKHITNIELNPKVRLQRYLKQLESVDLT*" /label="ydeQ CDS" gene 537266..537859 /gene="ydeQ" /locus_tag="BSU_05300" /old_locus_tag="BSU05300" /label="ydeQ gene" CDS complement(538003..539190) /gene="ydeR" /locus_tag="BSU_05310" /old_locus_tag="BSU05310" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388412.1" /db_xref="EnsemblGenomes-Gn:BSU05310" /db_xref="EnsemblGenomes-Tr:CAB12338" /db_xref="GOA:P96675" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12145" /db_xref="UniProtKB/Swiss-Prot:P96675" /translation="MANGNKQAGQRISPSLTLLLATACGIIVANLYYAQPLVGLISKA IGLSPSGAGLIVTLTQIGYVAGLLFLVPLGDIIENKKLIVVSLLLSAAALTLTAFVKH GTLFLAAAFFVGLGSIAAQVLVPFASYLASDAARGRVVGNVMSGLLLGIMLSRPISSL VADIWGWNAIFALSAVVSVILAIVLSKVLPARKPTANTNYTALLGSMWKLLRTTPVLR RRAIYHAFVFGAFSLFWTTVPLLLSGPDFHFSQKAIALYALVGIAGAVTAPIGGRLAD RGLTRLATGIALGVVVVSLLLPLMIQSSSPVGITVLVAAAILLDMGVSANLVLSQRAI FSLAPEIRSRLNGLFMAIFFLGGAIGSSIGGWAYASGGWSTALWIGIAFPVIALLYFI TEK*" /label="ydeR CDS" gene complement(538003..539190) /gene="ydeR" /locus_tag="BSU_05310" /old_locus_tag="BSU05310" /label="ydeR gene" promotor_-35 539326..539330 /Source="Nicolas_upshift_promotors" /id="U411" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.605394605394605" /psig="0.999000999001" /xcortree=2381 /SigmaFactorBS="aaaaataatatactaaacgttcagttttgtaaatggatttct GTTTTctttttttattcaaTTTAAGTATACTGAACGTATagtttatattgcgggaagg a" /listShort="ydeS, ydzO" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 539344 /Source="Nicolas_upshifts" /id="U411" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.605394605394605" /psig="0.999000999001" /xcortree=2381 /SigmaFactorBS="aaaaataatatactaaacgttcagttttgtaaatggatttct GTTTTctttttttattcaaTTTAAGTATACTGAACGTATagtttatattgcgggaagg a" /listShort="ydeS, ydzO" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 539345..539364 /Source="Nicolas_upshift_promotors" /id="U411" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.605394605394605" /psig="0.999000999001" /xcortree=2381 /SigmaFactorBS="aaaaataatatactaaacgttcagttttgtaaatggatttct GTTTTctttttttattcaaTTTAAGTATACTGAACGTATagtttatattgcgggaagg a" /listShort="ydeS, ydzO" /GFF_Attribute="listLong" /label="promotor_-10" CDS 539394..539990 /gene="ydeS" /locus_tag="BSU_05320" /old_locus_tag="BSU05320" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15944459; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (TetR/AcrR family)" /protein_id="NP_388413.1" /db_xref="EnsemblGenomes-Gn:BSU05320" /db_xref="EnsemblGenomes-Tr:CAB12339" /db_xref="GOA:P96676" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR011075" /db_xref="InterPro:IPR036271" /db_xref="SubtiList:BG12146" /db_xref="UniProtKB/Swiss-Prot:P96676" /translation="MQSKRGRPRDEGTHKAILSAAYDLLLEKGFDAVTVDKIAERAKV SKATIYKWWSNKAAVIMDSFLSTATDRLPVPDTGSSVQDIVTHATNLARFLTSREGTV IKELIGAGQLDEKLAEEYRTRFFQPRRLQAKGLLEKGIQKGELRENLDIEVSIDLIYG PIFYRLLITGDEVNDSYVRDLVMNAFKGVQATSATESM*" /label="ydeS CDS" gene 539394..539990 /gene="ydeS" /locus_tag="BSU_05320" /old_locus_tag="BSU05320" /label="ydeS gene" CDS 540104..540289 /gene="ydzO" /locus_tag="BSU_05329" /old_locus_tag="BSU05329" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097684.1" /db_xref="EnsemblGenomes-Gn:BSU05329" /db_xref="EnsemblGenomes-Tr:CAX52555" /db_xref="UniProtKB/Swiss-Prot:C0H3V9" /translation="MSKKKSFNREYITSYYYIPFHRLEQGFYTSMEYRKVGVFKQQGK IDGHYVGVMAMEKILAM*" /label="ydzO CDS" gene 540104..540289 /gene="ydzO" /locus_tag="BSU_05329" /old_locus_tag="BSU05329" /label="ydzO gene" downshifts 540268 /Source="Nicolas_upshifts" /id="D254" /incds=0 /nref=5 /ntot=123 /MaxReadThrough="1.06987" /MaxDrop="2.89833" /score="-5.04743481" /energy="-6.3" /TU="NA" /idTUdmin="U411" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 540401..540404 /Source="Nicolas_upshift_promotors" /id="U412" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.356643356643357" /psig="0.99000999000999" /xcortree=2480 /SigmaFactorBS="tctatgaccactcccataactgaaatagtctaatatttatac cagaagggATTGtttatataaataaaAGTTTATATAATGACGGGGGcgctaaggaaac g" /listShort="S186, aseR, ydfA, ydzS, ydzS" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 540411..540597 /Source="Nicolas_S_feature" /locus_tag="new_579354_579540" /HighExp="LBGstat, G180, LBGexp, G135, Paraq, G150, Oxctl, dia0, Diami, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S186" upshifts 540411 /Source="Nicolas_upshifts" /id="U412" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.356643356643357" /psig="0.99000999000999" /xcortree=2480 /SigmaFactorBS="tctatgaccactcccataactgaaatagtctaatatttatac cagaagggATTGtttatataaataaaAGTTTATATAATGACGGGGGcgctaaggaaac g" /listShort="S186, aseR, ydfA, ydzS, ydzS" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 540419..540438 /Source="Nicolas_upshift_promotors" /id="U412" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.356643356643357" /psig="0.99000999000999" /xcortree=2480 /SigmaFactorBS="tctatgaccactcccataactgaaatagtctaatatttatac cagaagggATTGtttatataaataaaAGTTTATATAATGACGGGGGcgctaaggaaac g" /listShort="S186, aseR, ydfA, ydzS, ydzS" /GFF_Attribute="listLong" /label="promotor_-10" CDS 540598..540933 /gene="aseR" /locus_tag="BSU_05330" /old_locus_tag="BSU05330" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:15948947, 16430705" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15948947, 16430705; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (metals sensing ArsR-SmtB repressors family)" /protein_id="NP_388414.1" /db_xref="EnsemblGenomes-Gn:BSU05330" /db_xref="EnsemblGenomes-Tr:CAB12340" /db_xref="GOA:P96677" /db_xref="InterPro:IPR001845" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12147" /db_xref="UniProtKB/Swiss-Prot:P96677" /translation="MTIDVAAMTRCLKTLSDQTRLIMMRLFLEQEYCVCQLVDMFEMS QPAISQHLRKLKNAGFVNEDRRGQWRYYSINGSCPEFDTLQLILHQIDQEDELLNHIK QKKTQACCQ*" /label="aseR CDS" gene 540598..540933 /gene="aseR" /locus_tag="BSU_05330" /old_locus_tag="BSU05330" /label="aseR gene" CDS 540946..542253 /gene="arsF" /locus_tag="BSU_05340" /old_locus_tag="BSU05340" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12950922, 14970228, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="arsenite/antimonite/H+ antiporter" /protein_id="NP_388415.1" /db_xref="EnsemblGenomes-Gn:BSU05340" /db_xref="EnsemblGenomes-Tr:CAB12341" /db_xref="GOA:P96678" /db_xref="InterPro:IPR000802" /db_xref="SubtiList:BG12148" /db_xref="UniProtKB/Swiss-Prot:P96678" /translation="MTSMILAVFIFLLTLVLVIWQPKNLSIGWSACGGAVLALIAGVV NFHDVLTVTGIVWNATLAFVAIILISLILDNIGFFEWAALHMAKAAKGYGVRMFVYVS LLGAIVAALFANDGAALILTPIVLAMVRALHFNEKLVFPFIIASGFIADTTSLPFVVS NLVNIVSADYFHITFIDYASRMVVPYLFSLLASIIVLYLFFRKSIPKRYDLTEVKKPV EAIKDQNMFRLSWYILGLLLIGYFASEFFSIPVSVVAGSIAIIFLIAAQKSPAVHTKK VVKEAPWAIVFFSIGMYVVVYGVRNAGLTDVLSDVIQAAADQGLFAGTIGMGFIAAIL SSIMNNLPTVMIDALAIAGTDTHGMMREALIYANVIGSDLGPKITPIGSLATLLWLHV LSHKGMKISWGTYFKTGIILTIPTLLITLVGLYIWLLIIHSCF*" /label="arsF CDS" gene 540946..542253 /gene="arsF" /locus_tag="BSU_05340" /old_locus_tag="BSU05340" /label="arsF gene" CDS 542285..542389 /gene="ydzSn" /locus_tag="BSU_05343" /old_locus_tag="BSU05343" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; N-terminal part of ydzS" /translation="CTGNSCRSQMAEGWGRKYLGAKWNVYSAGIEAQG*" /label="ydzSn CDS" gene 542285..542389 /gene="ydzSn" /locus_tag="BSU_05343" /old_locus_tag="BSU05343" /pseudo /label="ydzSn gene" CDS 542398..542511 /gene="ydzSc" /locus_tag="BSU_05344" /old_locus_tag="BSU05344" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; C-terminal part of ydzS" /translation="AVKAMKEAGIDISNQTSEKFDDPAKAHGTEEVFPKGP*" /label="ydzSc CDS" gene 542398..542511 /gene="ydzSc" /locus_tag="BSU_05344" /old_locus_tag="BSU05344" /pseudo /label="ydzSc gene" promotor_-35 542697..542705 /Source="Nicolas_upshift_promotors" /id="U413" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=429 /SigmaFactorBS="cagggaagttatttagctggtgacAGAGGAAAAttgatttgt gAACAGAATCATGAAGGAGAcggtgttttaaaggagttgtctgttttgcaggaattaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 542716..542734 /Source="Nicolas_upshift_promotors" /id="U413" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=429 /SigmaFactorBS="cagggaagttatttagctggtgacAGAGGAAAAttgatttgt gAACAGAATCATGAAGGAGAcggtgttttaaaggagttgtctgttttgcaggaattaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 542733 /Source="Nicolas_upshifts" /id="U413" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=429 /SigmaFactorBS="cagggaagttatttagctggtgacAGAGGAAAAttgatttgt gAACAGAATCATGAAGGAGAcggtgttttaaaggagttgtctgttttgcaggaattaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 542751..543536 /gene="ydfB" /locus_tag="BSU_05350" /old_locus_tag="BSU05350" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12793527; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_388416.1" /db_xref="EnsemblGenomes-Gn:BSU05350" /db_xref="EnsemblGenomes-Tr:CAB12342" /db_xref="GOA:P96679" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR027365" /db_xref="SubtiList:BG12149" /db_xref="UniProtKB/Swiss-Prot:P96679" /translation="MSVLQELTKKKYSSLKTMFDDKYCPTFVYSILDQTIPGAVYADD QTFPKSFFIGTESGIYFIAGDQGNRDFHDFIAGYYEEQVKSSKRFTLFSSSDTWDSVL KPILKDDLNQMRRAAFSYQPKSFKKTLQLPKGLVLKRIDEDIISHSTAFNSAYYEEYW NSVSQFASKGFGFAVLHGNHVVSECTSIFLGHNRAEMDIYTLEEYRGLGLAYCVANRF IAFCMENGIVPSWDCDICNNSSIALAAKLGFKTVTEYTIYYSG*" /label="ydfB CDS" gene 542751..543536 /gene="ydfB" /locus_tag="BSU_05350" /old_locus_tag="BSU05350" /label="ydfB gene" downshifts 542798 /Source="Nicolas_upshifts" /id="D255" /incds=0 /nref=3 /ntot=24 /MaxReadThrough="2.67554" /MaxDrop="5.08398" /score="39.1565399" /energy="-19.2" /TU="NA" /idTUdmin="U413" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 543546 /Source="Nicolas_upshifts" /id="D256" /incds=0 /nref=2 /ntot=90 /MaxReadThrough="0.161840000000001" /MaxDrop="3.51451" /score="-0.169292431" /energy="-13.6" /TU="NA" /idTUdmin="U413" /TUdmin=748 /isTUend="FALSE" /label="downshifts" CDS complement(543593..544513) /gene="ydfC" /locus_tag="BSU_05360" /old_locus_tag="BSU05360" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative aminoacid exporter" /protein_id="NP_388417.1" /db_xref="EnsemblGenomes-Gn:BSU05360" /db_xref="EnsemblGenomes-Tr:CAB12343" /db_xref="GOA:P96680" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG12150" /db_xref="UniProtKB/Swiss-Prot:P96680" /translation="MRKKTVQIMISHSLMIGLWASAFPGIRAGLEGYTPEHLALFRLL IGSMALLLFAVLTQMRLPDLKDIPAIFLLGFLGFAFYHILLNIGEKTVSAGVASLLVT TAPIFSAMLSRLFYKEHFGFTKWLGSMISLLGVLLIAFGAGDFTYSMSGILVILLAAF SESIYFVFQARYIKKYGFIPFVTFTIWGGTIPMLVFLPGLGEEMMNASISATLSIVYL GLLPTVIPYFALAYVTSFVGASEATLSLYVTPALALIISWLWIGEIPTLLSLLGGVVT VGGVCFTYLKVNKMNKIFITHFSAKRVKKL*" /label="ydfC CDS" gene complement(543593..544513) /gene="ydfC" /locus_tag="BSU_05360" /old_locus_tag="BSU05360" /label="ydfC gene" CDS 544646..546094 /gene="ydfD" /locus_tag="BSU_05370" /old_locus_tag="BSU05370" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15223311, 28348215; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative PLP-dependent transcriptional regulator" /protein_id="NP_388418.1" /db_xref="EnsemblGenomes-Gn:BSU05370" /db_xref="EnsemblGenomes-Tr:CAB12344" /db_xref="GOA:P96681" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12151" /db_xref="UniProtKB/Swiss-Prot:P96681" /translation="MSFPEEKKMKKLPKYRQIVHFIKEKIGNGEWPIGSKIPSQRTLA KDFQVNRSTVITALEELMADGLIEGTMGKGTVVINNTWTLMAKNSAPDWDQYVTSGIQ MPSRKIVQEINQSESNTDLIQLSKGELSAEIFPLAVMKEMMGKVSQHMEAFGYEEPKG YLPLREALSNYLKTIGINVSSSSILIVSGALQALQLISMGLLQRGSTVYLDQPSYLYS LHVFQSAGMKLTGLPMDNEGLLPENVHLTRGERGRAILYTNPCFHNPTGILMSKKRRE EILAVSENTQLPIIEDDIYRELWIDEIPPYPIKTIDKNGHVLYIGSLSKTLSPGLRIG WIVGPEPVIERLSDIKMQTDYGSSSLSQRVAAEWFTSGHYQQHVEKVRQQLKVRRELA LSALETHLKEVATWNIPKGGFFVWIKILPSISMKLLYTKALSKGILINLGSIYAQEKG NYIRLSYAYASLEDLQKGIYELGLMIKELASR*" /label="ydfD CDS" gene 544646..546094 /gene="ydfD" /locus_tag="BSU_05370" /old_locus_tag="BSU05370" /label="ydfD gene" CDS complement(546212..546835) /gene="ydfE" /locus_tag="BSU_05380" /old_locus_tag="BSU05380" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative flavoprotein" /protein_id="NP_388419.1" /db_xref="EnsemblGenomes-Gn:BSU05380" /db_xref="EnsemblGenomes-Tr:CAB12345" /db_xref="GOA:P96682" /db_xref="InterPro:IPR002563" /db_xref="InterPro:IPR012349" /db_xref="SubtiList:BG12152" /db_xref="UniProtKB/Swiss-Prot:P96682" /translation="MDIKKQDTRRFKEIKPKIMYYGTSTFLLTTLNEDGTTNISPMSS SWALGHYIILGVGLGGKAIDNLERHKECVINLPGPDLWENVERISSYSGKKSIPPLKK QIGFTYKKEKYEAAGLTPLQSKTVSPTRIKECPIQIEAEVKHIRLPEYESSFAIVETQ ALHFHAEESIILDENHINPSKWSPLIYNFRHYFGLGREVGKTFRSET*" /label="ydfE CDS" gene complement(546212..546835) /gene="ydfE" /locus_tag="BSU_05380" /old_locus_tag="BSU05380" /label="ydfE gene" promotor_-10 complement(546859..546878) /Source="Nicolas_upshift_promotors" /id="U414" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.398601398601399" /psig="0.999000999001" /xcortree=2726 /SigmaFactorBS="atattaggattcatgattttcctccttacattcatatttCGA TGATagttgaaatgttaaTCCTTTACAATATAAATGTAagcgtgacaaggaggaaaaa a" /listShort="ydfE" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 546867..546874 /Source="Nicolas_upshift_promotors" /id="U415" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.815184815184815" /psig=1 /xcortree=2389 /SigmaFactorBS="tccaacgttttttcctccttgtcacgcttacatttaTATTGT AAaggattaacatttcAACTATCATCGAAATATGAAtgtaaggaggaaaatcatgaat c" /listShort="ydfF" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(546878) /Source="Nicolas_upshifts" /id="U414" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.398601398601399" /psig="0.999000999001" /xcortree=2726 /SigmaFactorBS="atattaggattcatgattttcctccttacattcatatttCGA TGATagttgaaatgttaaTCCTTTACAATATAAATGTAagcgtgacaaggaggaaaaa a" /listShort="ydfE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 546889..546908 /Source="Nicolas_upshift_promotors" /id="U415" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.815184815184815" /psig=1 /xcortree=2389 /SigmaFactorBS="tccaacgttttttcctccttgtcacgcttacatttaTATTGT AAaggattaacatttcAACTATCATCGAAATATGAAtgtaaggaggaaaatcatgaat c" /listShort="ydfF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 546891 /Source="Nicolas_upshifts" /id="U415" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.815184815184815" /psig=1 /xcortree=2389 /SigmaFactorBS="tccaacgttttttcctccttgtcacgcttacatttaTATTGT AAaggattaacatttcAACTATCATCGAAATATGAAtgtaaggaggaaaatcatgaat c" /listShort="ydfF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(546893..546899) /Source="Nicolas_upshift_promotors" /id="U414" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.398601398601399" /psig="0.999000999001" /xcortree=2726 /SigmaFactorBS="atattaggattcatgattttcctccttacattcatatttCGA TGATagttgaaatgttaaTCCTTTACAATATAAATGTAagcgtgacaaggaggaaaaa a" /listShort="ydfE" /GFF_Attribute="listLong" /label="promotor_-35" CDS 546925..547605 /gene="ydfF" /locus_tag="BSU_05390" /old_locus_tag="BSU05390" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_388420.1" /db_xref="EnsemblGenomes-Gn:BSU05390" /db_xref="EnsemblGenomes-Tr:CAB12346" /db_xref="GOA:P96683" /db_xref="InterPro:IPR001845" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12153" /db_xref="UniProtKB/Swiss-Prot:P96683" /translation="MNPNIAKISSLLSDPSRSSILLSLMDGRIHPAGELAYLANIKPQ TASFHLNKLLEAKLISVEKHGRHRYYRLADSDAANVIEQLLHIAPKAKVKSLKESKEK KDLHFARTCYDHLAGYVGVQMAHSLVEQGMLKKVDLNFEVTSEGALFFSKLGINEEQQ RNKRRAFARCCLDWSERQHHIAGALGNALLVRMLEEEWIVRMPKTRAIRITQSGKIAF EKHLNVKI*" /label="ydfF CDS" gene 546925..547605 /gene="ydfF" /locus_tag="BSU_05390" /old_locus_tag="BSU05390" /label="ydfF gene" downshifts 547638 /Source="Nicolas_upshifts" /id="D257" /incds=0 /nref=113 /ntot=245 /MaxReadThrough="0.50202" /MaxDrop="4.24716" /score="-7.74889591" /energy="-4.5" /TU="U415" /idTUdmin="U415" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(547685..548128) /gene="ydfG" /locus_tag="BSU_05400" /old_locus_tag="BSU05400" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388421.1" /db_xref="EnsemblGenomes-Gn:BSU05400" /db_xref="EnsemblGenomes-Tr:CAB12347" /db_xref="GOA:P96684" /db_xref="InterPro:IPR003779" /db_xref="InterPro:IPR004675" /db_xref="InterPro:IPR029032" /db_xref="SubtiList:BG12154" /db_xref="UniProtKB/Swiss-Prot:P96684" /translation="MSQRVSYYEIAPEGMKIMMDMEKYTKQSSINRTTRELIKIRVSQ MNGCAFCIDMHTSDARKMGETEQRIYCLHAWNECDFYSPEEKAALELSEHITLIPSKR VPDELYHRVREHYDEEQYVDLVLIINQINSWNRISIAMGNRAASK*" /label="ydfG CDS" gene complement(547685..548128) /gene="ydfG" /locus_tag="BSU_05400" /old_locus_tag="BSU05400" /label="ydfG gene" downshifts complement(547690) /Source="Nicolas_upshifts" /id="D258" /incds=0 /nref=10 /ntot=187 /MaxReadThrough="1.76648" /MaxDrop="3.73786" /score="0.225628164" /energy="-10.8" /TU="NA" /idTUdmin="U416" /TUdmin=2 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(548151..548170) /Source="Nicolas_upshift_promotors" /id="U416" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2022 /SigmaFactorBS="gcttctttccaaaagacgctgaaacagctgtcattcaaaccg caCATTGGTAaaatgatcaatacCGGGATACAATCTAGGTATTctatggaaaggagtc t" /listShort="ydfG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(548175) /Source="Nicolas_upshifts" /id="U416" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2022 /SigmaFactorBS="gcttctttccaaaagacgctgaaacagctgtcattcaaaccg caCATTGGTAaaatgatcaatacCGGGATACAATCTAGGTATTctatggaaaggagtc t" /listShort="ydfG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(548184..548191) /Source="Nicolas_upshift_promotors" /id="U416" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2022 /SigmaFactorBS="gcttctttccaaaagacgctgaaacagctgtcattcaaaccg caCATTGGTAaaatgatcaatacCGGGATACAATCTAGGTATTctatggaaaggagtc t" /listShort="ydfG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(548214..548393) /gene="ydzP" /locus_tag="BSU_05408" /old_locus_tag="BSU05408" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097685.1" /db_xref="EnsemblGenomes-Gn:BSU05408" /db_xref="EnsemblGenomes-Tr:CAX52558" /db_xref="GOA:C0H3W0" /db_xref="UniProtKB/Swiss-Prot:C0H3W0" /translation="MNMYWFLGALLYFLIGTYIFIRVTRDSQSGSWILLALAAPLIIA GYPYFYSKKLLSKRR*" /label="ydzP CDS" gene complement(548214..548393) /gene="ydzP" /locus_tag="BSU_05408" /old_locus_tag="BSU05408" /label="ydzP gene" CDS complement(548390..548533) /gene="ydzQ" /locus_tag="BSU_05409" /old_locus_tag="BSU05409" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097686.1" /db_xref="EnsemblGenomes-Gn:BSU05409" /db_xref="EnsemblGenomes-Tr:CAX52559" /db_xref="UniProtKB/Swiss-Prot:C0H3W1" /translation="MKSIDLTILSLKRKGIRTEKVLKNQNPDRLSHMTDKNAQPKSKE KEE*" /label="ydzQ CDS" gene complement(548390..548533) /gene="ydzQ" /locus_tag="BSU_05409" /old_locus_tag="BSU05409" /label="ydzQ gene" promotor_-35 548484..548486 /Source="Nicolas_upshift_promotors" /id="U417" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.649350649350649" /psig="0.998001998001998" /xcortree=2487 /SigmaFactorBS="tctgattttttaataccttttcggtcCGGattccttttctct ttAATGATAAAATTGTGAGATCaatcgatttcaatgatgatcattccttcaatgaata g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 548502..548521 /Source="Nicolas_upshift_promotors" /id="U417" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.649350649350649" /psig="0.998001998001998" /xcortree=2487 /SigmaFactorBS="tctgattttttaataccttttcggtcCGGattccttttctct ttAATGATAAAATTGTGAGATCaatcgatttcaatgatgatcattccttcaatgaata g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 548518 /Source="Nicolas_upshifts" /id="U417" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.649350649350649" /psig="0.998001998001998" /xcortree=2487 /SigmaFactorBS="tctgattttttaataccttttcggtcCGGattccttttctct ttAATGATAAAATTGTGAGATCaatcgatttcaatgatgatcattccttcaatgaata g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 548801..550024 /gene="ydfH" /locus_tag="BSU_05410" /old_locus_tag="BSU05410" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295, 15941986" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15941986; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YdfI]" /protein_id="NP_388422.1" /db_xref="EnsemblGenomes-Gn:BSU05410" /db_xref="EnsemblGenomes-Tr:CAB12348" /db_xref="GOA:P96685" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12155" /db_xref="UniProtKB/Swiss-Prot:P96685" /translation="MLIRNPFKDKYYSHDRRALNMLALRVPGLAFILMIYIASIVLQF VSGGWSILLLYAFTILIAIFALLHWHSYRWVKKRVILYFAVQGLITFALANLMTGFFI LVIIGLYAFLIGQIIGMADRRRTFLILYLLLLLVINSAYHLHKGEVLHFIVIAAPIMI VIITYAATFFAQVDEKIKAQLTLERLELAHQQVEQLTLQNERQRMARDLHDTLAQGLV SLNMQLDAIHVHLAKGNTERAKEIIQQSMKRVKSTIADARSAIDDLRSKSEEIGVLKE RITSLMDHFIESTGMACLLDYRLHQVLDVRTAENCYYIIGECMTNAAKHAEAKTIWIS IWDDEKGRLHLTVKDNGKGFDVEKGKKKRGHYGLLGIQERVRAINGQFNIKSTKLKGT QIEITVPIQGEMQDE*" /label="ydfH CDS" gene 548801..550024 /gene="ydfH" /locus_tag="BSU_05410" /old_locus_tag="BSU05410" /label="ydfH gene" CDS 550017..550658 /gene="ydfI" /locus_tag="BSU_05420" /old_locus_tag="BSU05420" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 15941986" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15941986; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YdfH]" /protein_id="NP_388423.1" /db_xref="EnsemblGenomes-Gn:BSU05420" /db_xref="EnsemblGenomes-Tr:CAB12349" /db_xref="GOA:P96686" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12156" /db_xref="UniProtKB/Swiss-Prot:P96686" /translation="MNKVLIVDDHLVVREGLKLLIETNDQYTIIGEAENGKVAVRLAD ELEPDIILMDLYMPEMSGLEAIKQIKEKHDTPIIILTTYNEDHLMIEGIELGAKGYLL KDTSSETLFHTMDAAIRGNVLLQPDILKRLQEIQFERMKKQRNETQLTEKEVIVLKAI AKGLKSKAIAFDLGVSERTVKSRLTSIYNKLGANSRTEAVTIAMQKGILTIDN*" /label="ydfI CDS" gene 550017..550658 /gene="ydfI" /locus_tag="BSU_05420" /old_locus_tag="BSU05420" /label="ydfI gene" downshifts 550652 /Source="Nicolas_upshifts" /id="D259" /incds=0 /nref=5 /ntot=147 /MaxReadThrough="1.15378" /MaxDrop="2.65603" /score="8.33575703" /energy="-6.4" /TU="NA" /idTUdmin="U419" /TUdmin="-176" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(550685..550704) /Source="Nicolas_upshift_promotors" /id="U418" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.796203796203796" /psig="0.999000999001" /xcortree=1843 /SigmaFactorBS="tcctttcaacacattgcttgatcacattctttctcattgtaG TTGACAAtgaaatgaaaaaaACGTACATTCGGGCATGTACgtttgggcaattttcaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(550706) /Source="Nicolas_upshifts" /id="U418" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.796203796203796" /psig="0.999000999001" /xcortree=1843 /SigmaFactorBS="tcctttcaacacattgcttgatcacattctttctcattgtaG TTGACAAtgaaatgaaaaaaACGTACATTCGGGCATGTACgtttgggcaattttcaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(550718..550725) /Source="Nicolas_upshift_promotors" /id="U418" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.796203796203796" /psig="0.999000999001" /xcortree=1843 /SigmaFactorBS="tcctttcaacacattgcttgatcacattctttctcattgtaG TTGACAAtgaaatgaaaaaaACGTACATTCGGGCATGTACgtttgggcaattttcaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 550766..550771 /Source="Nicolas_upshift_promotors" /id="U419" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.833166833166833" /psig="0.833166833166833" /xcortree=1016 /SigmaFactorBS="actacaatgagaaagaatgtgatcaagcaatgtgttgaaagg AGATTAtcatgtcaaaaatgTTATATACATTAGGAGGATgggttgctcgcaatcgcat a" /listShort="ydfJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS 550774..552948 /gene="ydfJ" /locus_tag="BSU_05430" /old_locus_tag="BSU05430" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15941986; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative proton metabolite efflux transporter" /protein_id="NP_388424.1" /db_xref="EnsemblGenomes-Gn:BSU05430" /db_xref="EnsemblGenomes-Tr:CAB12350" /db_xref="GOA:P96687" /db_xref="InterPro:IPR000731" /db_xref="InterPro:IPR004869" /db_xref="SubtiList:BG12157" /db_xref="UniProtKB/Swiss-Prot:P96687" /translation="MSKMLYTLGGWVARNRIKAICAWIVVLVAAIGLAVTLKPSFSED MSIPDTPSEKAMDVIQKEFPHGPDKGSIRVIFGAGDGEKLTGKPAKKAIEDTFKEISK DDSVDSIASPFVTGTIAKDGTVAYADIQYKSSADDIKDYSIKHLKDSLKMADDEGLQT ELSGDVPGAEMEIGGVSEIVGIILAFVVLAITFGSLLIAGLPILTALIGLGVSIGLVL IGTQVFDIASVSLSLAGMIGLAVGIDYALFIFTKHRQFLGEGIQKNESIARAVGTAGS AVVFAGLTVIVALCGLTVVNIPFMSAMGLTAGLSVLMAVLASITLVPAVLSIAGKRMI PKSNKKIEKQSTETNVWGRFVTKNPIMLSVCSILILIVISIPSMHLELGLPDAGMKAK DNPDRRAYDLLAEGFGEGFNGQLTIVADATNATENKAEAFADAVKEIKGLDHVASVTP AMPNKEGNFAIITVVPETGPNDVTTKDLVHDVRSLSDKNGVDLLVTGSTAVNIDISDR LNDAIPVFAVLIVGFAFVLLTIVFRSLLVPLVAVAGFMLTMTATLGICVFVLQDGNLI DFFKIPEKGPILAFLPILSIGILFGLAMDYQVFLVSRMREEYVKTNNPVQAIQAGLKH SGPVVTAAGLIMIFVFAGFIFAGEASIKANGLALSFGVLFDAFIVRMTLIPSVMKLMG NAAWYLPKWLDKIIPNVDIEGHQLTKEIQPEIDHEQKKQISV*" /label="ydfJ CDS" gene 550774..552948 /gene="ydfJ" /locus_tag="BSU_05430" /old_locus_tag="BSU05430" /label="ydfJ gene" upshifts 550784 /Source="Nicolas_upshifts" /id="U419" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.833166833166833" /psig="0.833166833166833" /xcortree=1016 /SigmaFactorBS="actacaatgagaaagaatgtgatcaagcaatgtgttgaaagg AGATTAtcatgtcaaaaatgTTATATACATTAGGAGGATgggttgctcgcaatcgcat a" /listShort="ydfJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 550786..550804 /Source="Nicolas_upshift_promotors" /id="U419" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.833166833166833" /psig="0.833166833166833" /xcortree=1016 /SigmaFactorBS="actacaatgagaaagaatgtgatcaagcaatgtgttgaaagg AGATTAtcatgtcaaaaatgTTATATACATTAGGAGGATgggttgctcgcaatcgcat a" /listShort="ydfJ" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature complement(551850..551868) /Source="Nicolas_upshift_promotors" /id="U420" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.763236763236763" /psig="0.763236763236763" /xcortree=1205 /SigmaFactorBS="atgcatagatgggatactaatgacgatcaaaatcagaatgct GCATACACTTAGCATGATAggatttttggtgacaaagcgtccccagacatttgtttca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(551850) /Source="Nicolas_upshifts" /id="U420" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.763236763236763" /psig="0.763236763236763" /xcortree=1205 /SigmaFactorBS="atgcatagatgggatactaatgacgatcaaaatcagaatgct GCATACACTTAGCATGATAggatttttggtgacaaagcgtccccagacatttgtttca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(552952..553359) /Source="Nicolas_S_feature" /locus_tag="new_591895_592302_c" /HighExp="Paraq, H2O2, Oxctl, aero, LBGexp, dia15, GM 150, M/G, ferm, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S187" promotor_-35 552969..552973 /Source="Nicolas_upshift_promotors" /id="U421" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=3115 /SigmaFactorBS="aacaaaagaaacaaatcagtgtgtaatagaaaaagcagatct tttaTGATCtgctcttttgctTATGGTAGTATTTAGAAGATgaagtcggcagttaaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 552983 /Source="Nicolas_upshifts" /id="U421" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=3115 /SigmaFactorBS="aacaaaagaaacaaatcagtgtgtaatagaaaaagcagatct tttaTGATCtgctcttttgctTATGGTAGTATTTAGAAGATgaagtcggcagttaaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 552986..553005 /Source="Nicolas_upshift_promotors" /id="U421" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=3115 /SigmaFactorBS="aacaaaagaaacaaatcagtgtgtaatagaaaaagcagatct tttaTGATCtgctcttttgctTATGGTAGTATTTAGAAGATgaagtcggcagttaaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(552997) /Source="Nicolas_upshifts" /id="D260" /incds=0 /nref=22 /ntot=134 /MaxReadThrough="-0.100210000000001" /MaxDrop="3.637" /score="4.29161871" /energy="-8.8" /TU="NA" /idTUdmin="U422" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" CDS complement(553360..554262) /gene="cesA" /locus_tag="BSU_05440" /old_locus_tag="BSU05440" /EC_number="3.1.1.1" /function="16.8: Protect" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7765103, 22248594, 24418394" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7765103, 22248594, 24418394; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="carboxylesterase NP" /protein_id="NP_388425.1" /db_xref="EnsemblGenomes-Gn:BSU05440" /db_xref="EnsemblGenomes-Tr:CAB12351" /db_xref="GOA:P96688" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="PDB:2R11" /db_xref="SubtiList:BG11957" /db_xref="UniProtKB/Swiss-Prot:P96688" /translation="MSNHSSSIPELSDNGIRYYQTYNESLSLWPVRCKSFYISTRFGQ THVIASGPEDAPPLVLLHGALFSSTMWYPNIADWSSKYRTYAVDIIGDKNKSIPENVS GTRTDYANWLLDVFDNLGIEKSHMIGLSLGGLHTMNFLLRMPERVKSAAILSPAETFL PFHHDFYKYALGLTASNGVETFLNWMMNDQNVLHPIFVKQFKAGVMWQDGSRNPNPNA DGFPYVFTDEELRSARVPILLLLGEHEVIYDPHSALHRASSFVPDIEAEVIKNAGHVL SMEQPTYVNERVMRFFNAETGISR*" /label="cesA CDS" gene complement(553360..554262) /gene="cesA" /locus_tag="BSU_05440" /old_locus_tag="BSU05440" /label="cesA gene" S_feature complement(554263..554358) /Source="Nicolas_S_feature" /locus_tag="new_593206_593301_c" /HighExp="nit, ferm, aero, LoTm, M/G, GM 150, Diami, Paraq, dia15, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S188" promotor_-10 complement(554338..554357) /Source="Nicolas_upshift_promotors" /id="U422" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=2448 /SigmaFactorBS="tcaataatctgtttcaatcgtttttttccttttcatcttgGA TTTGACgtctaataacaacTGTATTATATTGTAAATAAAgtctgttatatcaaaatca g" /listShort="S188, nap, S187" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(554358) /Source="Nicolas_upshifts" /id="U422" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=2448 /SigmaFactorBS="tcaataatctgtttcaatcgtttttttccttttcatcttgGA TTTGACgtctaataacaacTGTATTATATTGTAAATAAAgtctgttatatcaaaatca g" /listShort="S188, nap, S187" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(554371..554378) /Source="Nicolas_upshift_promotors" /id="U422" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=2448 /SigmaFactorBS="tcaataatctgtttcaatcgtttttttccttttcatcttgGA TTTGACgtctaataacaacTGTATTATATTGTAAATAAAgtctgttatatcaaaatca g" /listShort="S188, nap, S187" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(554464..555153) /gene="ydfK" /locus_tag="BSU_05450" /old_locus_tag="BSU05450" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10200972, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388426.1" /db_xref="EnsemblGenomes-Gn:BSU05450" /db_xref="EnsemblGenomes-Tr:CAB12352" /db_xref="GOA:P96689" /db_xref="InterPro:IPR007563" /db_xref="SubtiList:BG12158" /db_xref="UniProtKB/Swiss-Prot:P96689" /translation="MFGTIFNTVMIIAGSIIGGIFKKGIKDEYQDILMQAMGFAAVAL GINAITQHLPDSKYPILFIVSLAIGGLLGQIINLELRFNKLVNKFSKSNLAEGLSTAV LLFCIGSLSILGPVEAALHGDYTYLLTNGMLDGITSIVLASTFGFGIAAAALVLFSWQ GSIYLFAQVMESAINTDLINEITIVGGILILSSGLSILGIKKFKTLNLLPSLLIPPVV IFVIHAFGLRF*" /label="ydfK CDS" gene complement(554464..555153) /gene="ydfK" /locus_tag="BSU_05450" /old_locus_tag="BSU05450" /label="ydfK gene" CDS complement(555243..556055) /gene="ydfL" /locus_tag="BSU_05460" /old_locus_tag="BSU05460" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator of efflux transporter" /protein_id="NP_388427.1" /db_xref="EnsemblGenomes-Gn:BSU05460" /db_xref="EnsemblGenomes-Tr:CAB12353" /db_xref="GOA:P96690" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="InterPro:IPR010499" /db_xref="InterPro:IPR011256" /db_xref="InterPro:IPR029442" /db_xref="SubtiList:BG12159" /db_xref="UniProtKB/Swiss-Prot:P96690" /translation="MKEFFSIGEVSKLFNVKISALRYYDEIGLLKPEYKDEQTNYRYY STQQFERLDTIKYLRALGLPINKLLDFYNSQNTNTLLHLLKSQQVEIDRKKKELERIE RKISRRITHIEDAVNMPLHQISKIKLPAMRVAYLQHEYVLGHDIEHSLAELRTHLNVN EDIFIGKIGLSISAANVKAKQFDKYSSIFMILEDENEKTSSEIIFPSREYLQIRFKGS HPEAEPYYKKLLAYMKEHHYEVAGDSIEITLIDYGITNNLDNYVTEILLPIK*" /label="ydfL CDS" gene complement(555243..556055) /gene="ydfL" /locus_tag="BSU_05460" /old_locus_tag="BSU05460" /label="ydfL gene" promotor_-10 complement(556084..556103) /Source="Nicolas_upshift_promotors" /id="U423" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=1898 /SigmaFactorBS="tttttagaaggagttttttctttatgctgcaAACTTTACctt tagtactcgccgTACTATATAATGTGTGTATAtcaatcataggacagaaaggttgtta g" /listShort="ydfL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(556097) /Source="Nicolas_upshifts" /id="U423" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=1898 /SigmaFactorBS="tttttagaaggagttttttctttatgctgcaAACTTTACctt tagtactcgccgTACTATATAATGTGTGTATAtcaatcataggacagaaaggttgtta g" /listShort="ydfL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(556119..556126) /Source="Nicolas_upshift_promotors" /id="U423" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=1898 /SigmaFactorBS="tttttagaaggagttttttctttatgctgcaAACTTTACctt tagtactcgccgTACTATATAATGTGTGTATAtcaatcataggacagaaaggttgtta g" /listShort="ydfL" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(556166..557059) /gene="mneP" /locus_tag="BSU_05470" /old_locus_tag="BSU05470" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:27748968" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 27748968; Product type t: transporter" /codon_start=1 /transl_table=11 /product="primary Mn(II) efflux pump" /protein_id="NP_388428.2" /db_xref="EnsemblGenomes-Gn:BSU05470" /db_xref="EnsemblGenomes-Tr:CAB12354" /db_xref="GOA:C0SP78" /db_xref="InterPro:IPR002524" /db_xref="InterPro:IPR027469" /db_xref="InterPro:IPR027470" /db_xref="InterPro:IPR036837" /db_xref="SubtiList:BG12160" /db_xref="UniProtKB/Swiss-Prot:C0SP78" /translation="MASEREQISRKVALIALIANLILMAGKVFFGLVGDSEAVFADGI HSAADVVASIAVLAVIGISNKPPDQDHPFGHGKAEVISEAIVGIILVIVSVYILIEAI LSFVKGPSVPQYSALFAALISYVAKEILYRYSIKQGKKWNSKAIIAIAYDHKGDIVAS LAAFIGVLLAIIGNSRGWSYLLYADAIASAIVAYLIFKISMELIRPSVDVLMEKSVDP ELIEEYKAVIFQCDQVKRIDRIRAREHGHYKLLDVRLSLDHDLTIKQGHDIAREIRNE IKRQFSDVEEVLIHVNPYFEE*" /label="mneP CDS" gene complement(556166..557059) /gene="mneP" /locus_tag="BSU_05470" /old_locus_tag="BSU05470" /label="mneP gene" downshifts complement(556186) /Source="Nicolas_upshifts" /id="D261" /incds=0 /nref=23 /ntot=121 /MaxReadThrough="1.07979" /MaxDrop="4.0938" /score="12.079524" /energy="-6.2" /TU="NA" /idTUdmin="U424" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" S_feature complement(557060..557152) /Source="Nicolas_S_feature" /locus_tag="new_596003_596095_c" /HighExp="LPh, HPh, LPhT, UNK1, MG t5, MG 5, MG 15, BMM, GM 120, Fru" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S189" promotor_-10 complement(557133..557152) /Source="Nicolas_upshift_promotors" /id="U424" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=1748 /SigmaFactorBS="caccttatttattagtaaacaggaaacaacgttgcTATAGAC CcactcgaaattgaatTGGTATGATAAACAAAGTGAttacacaggaaaggatacggag a" /listShort="S189, ydfM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(557150) /Source="Nicolas_upshifts" /id="U424" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=1748 /SigmaFactorBS="caccttatttattagtaaacaggaaacaacgttgcTATAGAC CcactcgaaattgaatTGGTATGATAAACAAAGTGAttacacaggaaaggatacggag a" /listShort="S189, ydfM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(557168..557175) /Source="Nicolas_upshift_promotors" /id="U424" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=1748 /SigmaFactorBS="caccttatttattagtaaacaggaaacaacgttgcTATAGAC CcactcgaaattgaatTGGTATGATAAACAAAGTGAttacacaggaaaggatacggag a" /listShort="S189, ydfM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 557341..557348 /Source="Nicolas_upshift_promotors" /id="U425" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=3024 /SigmaFactorBS="agtgaaaaatttccacctaattttcaaaaaccTATTGACAtg agaagatctgtaTTTTACTATTATCTCATATTcaagatattttaatttgagatatttg g" /listShort="ydfN, ydfO, S190, ydfP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 557363..557382 /Source="Nicolas_upshift_promotors" /id="U425" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=3024 /SigmaFactorBS="agtgaaaaatttccacctaattttcaaaaaccTATTGACAtg agaagatctgtaTTTTACTATTATCTCATATTcaagatattttaatttgagatatttg g" /listShort="ydfN, ydfO, S190, ydfP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 557369 /Source="Nicolas_upshifts" /id="U425" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=3024 /SigmaFactorBS="agtgaaaaatttccacctaattttcaaaaaccTATTGACAtg agaagatctgtaTTTTACTATTATCTCATATTcaagatattttaatttgagatatttg g" /listShort="ydfN, ydfO, S190, ydfP" /GFF_Attribute="listLong" /label="upshifts" CDS 557535..558155 /gene="ydfN" /locus_tag="BSU_05480" /old_locus_tag="BSU05480" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17407181; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388429.1" /db_xref="EnsemblGenomes-Gn:BSU05480" /db_xref="EnsemblGenomes-Tr:CAB12355" /db_xref="GOA:P96692" /db_xref="InterPro:IPR000415" /db_xref="InterPro:IPR029479" /db_xref="PDB:3BEM" /db_xref="SubtiList:BG12161" /db_xref="UniProtKB/Swiss-Prot:P96692" /translation="MAEFTHLVNERRSASNFLSGHPITKEDLNEMFELVALAPSAFNL QHTKYVTVLDQDVKEKLKQAANGQYKVVSSSAVLLVLGDKQAYQQAADIYEGLKVLGI LNKQEYDHMVQDTVSFYENRGEQFKRDEAIRNASLSAMMFMLSAKEKGWDTCPMIGFD AEAVKRILNIDDQFEVVMMITIGKEKTESRRPRGYRKPVNEFVEYM*" /label="ydfN CDS" gene 557535..558155 /gene="ydfN" /locus_tag="BSU_05480" /old_locus_tag="BSU05480" /label="ydfN gene" promotor_-35 557879..557885 /Source="Nicolas_upshift_promotors" /id="U426" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=151 /SigmaFactorBS="tattggggatattaaataagcaagagtatgaccacatggtgc aagacacCGTTTCGttttatgaaaacaGGGGAGAACAATTTAAGAGagatgaggcgat a" /listShort="ydfO, S190, ydfP" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 557890 /Source="Nicolas_upshifts" /id="U426" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=151 /SigmaFactorBS="tattggggatattaaataagcaagagtatgaccacatggtgc aagacacCGTTTCGttttatgaaaacaGGGGAGAACAATTTAAGAGagatgaggcgat a" /listShort="ydfO, S190, ydfP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 557899..557917 /Source="Nicolas_upshift_promotors" /id="U426" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=151 /SigmaFactorBS="tattggggatattaaataagcaagagtatgaccacatggtgc aagacacCGTTTCGttttatgaaaacaGGGGAGAACAATTTAAGAGagatgaggcgat a" /listShort="ydfO, S190, ydfP" /GFF_Attribute="listLong" /label="promotor_-10" CDS 558171..559109 /gene="ydfO" /locus_tag="BSU_05490" /old_locus_tag="BSU05490" /EC_number="1.13.11.-" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17407181; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dioxygenase" /protein_id="NP_388430.1" /db_xref="EnsemblGenomes-Gn:BSU05490" /db_xref="EnsemblGenomes-Tr:CAB12356" /db_xref="GOA:P96693" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="PDB:3OAJ" /db_xref="SubtiList:BG12162" /db_xref="UniProtKB/Swiss-Prot:P96693" /translation="MAKKTMGIHHITAIVGHPQENTDFYAGVLGLRLVKQTVNFDDPG TYHLYFGNEGGKPGTIITFFPWAGARQGVIGDGQVGVTSYVVPKGAMAFWEKRLEKFN VPYTKIERFGEQYVEFDDPHGLHLEIVEREEGEANTWTFGEVTPDVAIKGFGGATLLS EQPDKTADLLENIMGLERVGKEGDFVRYRSAGDIGNVIDLKLTPIGRGQMGAGTVHHI AWRANDDEDQLDWQRYIASHGYGVTPVRDRNYFNAIYFREHGEILFEIATDPPGFAHD ETQETMGEKLMLPVQYEPHRTQIEQGLLPFEVRELD*" /label="ydfO CDS" gene 558171..559109 /gene="ydfO" /locus_tag="BSU_05490" /old_locus_tag="BSU05490" /label="ydfO gene" promotor_-35 559097..559100 /Source="Nicolas_upshift_promotors" /id="U427" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.658341658341658" /psig="0.658341658341658" /xcortree=729 /SigmaFactorBS="caaattgaacaagggctgctgccgtttgaagtaagAGAGtta gattgatttgaCACATAAAAAATAAAGAAACatatattcaattgatgattgctggatg g" /listShort="S190, ydfP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 559115..559134 /Source="Nicolas_upshift_promotors" /id="U427" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.658341658341658" /psig="0.658341658341658" /xcortree=729 /SigmaFactorBS="caaattgaacaagggctgctgccgtttgaagtaagAGAGtta gattgatttgaCACATAAAAAATAAAGAAACatatattcaattgatgattgctggatg g" /listShort="S190, ydfP" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 559122..559210 /Source="Nicolas_S_feature" /locus_tag="new_598065_598153" /HighExp="Etha, BT, S6, S7, S8, G/S, GM 10, Gly, GM 15, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigB, SigA" /TUshortPSig="0.658, 0.993, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S190" upshifts 559122 /Source="Nicolas_upshifts" /id="U427" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.658341658341658" /psig="0.658341658341658" /xcortree=729 /SigmaFactorBS="caaattgaacaagggctgctgccgtttgaagtaagAGAGtta gattgatttgaCACATAAAAAATAAAGAAACatatattcaattgatgattgctggatg g" /listShort="S190, ydfP" /GFF_Attribute="listLong" /label="upshifts" CDS 559211..559600 /gene="ydfP" /locus_tag="BSU_05500" /old_locus_tag="BSU05500" /EC_number="1.-.-.-" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15306018, 15849754, 16850406, 17407181; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane bound oxidoreductase" /protein_id="NP_388431.1" /db_xref="EnsemblGenomes-Gn:BSU05500" /db_xref="EnsemblGenomes-Tr:CAB12357" /db_xref="GOA:P96694" /db_xref="InterPro:IPR032808" /db_xref="SubtiList:BG12163" /db_xref="UniProtKB/Swiss-Prot:P96694" /translation="MEDAGLLLIRIMIGVVFLFYGTQKLFGWFGGYGIKGTGQWFESI GVKPGNVAAALSGLGELVSGILFILGVFLPLGAAIITIIMLGAIVKVHGAKGFANGAG GFEYNLVLIAVSIGVALIGSGAYALHF*" /label="ydfP CDS" gene 559211..559600 /gene="ydfP" /locus_tag="BSU_05500" /old_locus_tag="BSU05500" /label="ydfP gene" downshifts 559591 /Source="Nicolas_upshifts" /id="D262" /incds=0 /nref=3 /ntot=91 /MaxReadThrough="1.0642" /MaxDrop="3.85597" /score="-8.69038499" /energy="-9.3" /TU="NA" /idTUdmin="U427" /TUdmin=29 /isTUend="FALSE" /label="downshifts" misc_feature 559714..559733 /Source="Nicolas_upshift_promotors" /id="U428" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.665334665334665" /psig="0.946053946053946" /xcortree=2048 /SigmaFactorBS="cattttcggcaagcttgcaggtactctgcaaagcaaaaaagc ggatatcataaatataAATCTGTATAGTGAATGATAcgtattgatgagcttggtcatg a" /listShort="S191, ydfQ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 559716..559785 /Source="Nicolas_S_feature" /locus_tag="new_598659_598728" /HighExp="Diami, dia5, H2O2, dia15, Etha, S8, Paraq, Salt, LPhT, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.946" /TUlongSig="NA" /TUlongPSig="NA" /label="S191" upshifts 559716 /Source="Nicolas_upshifts" /id="U428" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.665334665334665" /psig="0.946053946053946" /xcortree=2048 /SigmaFactorBS="cattttcggcaagcttgcaggtactctgcaaagcaaaaaagc ggatatcataaatataAATCTGTATAGTGAATGATAcgtattgatgagcttggtcatg a" /listShort="S191, ydfQ" /GFF_Attribute="listLong" /label="upshifts" CDS 559786..560124 /gene="ydfQ" /locus_tag="BSU_05510" /old_locus_tag="BSU05510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15937154; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative thioredoxin or thiol-disulfide isomerase" /protein_id="NP_388432.1" /db_xref="EnsemblGenomes-Gn:BSU05510" /db_xref="EnsemblGenomes-Tr:CAB12358" /db_xref="GOA:P96695" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG12164" /db_xref="UniProtKB/Swiss-Prot:P96695" /translation="MKEMTGLHSLVSIENFIKQHKFSFIYISRPGCTVCHAVLPQLRI VLDQFPNIKLGHINADDVAEVAGRFSVFTVPVLLLFIDGTEFLREARFVHFEQLEQKL KRVYRLYEGE*" /label="ydfQ CDS" gene 559786..560124 /gene="ydfQ" /locus_tag="BSU_05510" /old_locus_tag="BSU05510" /label="ydfQ gene" downshifts 560112 /Source="Nicolas_upshifts" /id="D263" /incds=0 /nref=9 /ntot=28 /MaxReadThrough="1.76745" /MaxDrop="4.78737" /score="17.861178" /energy="-6" /TU="NA" /idTUdmin="U428" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(560164..560400) /gene="ydzH" /locus_tag="BSU_05520" /old_locus_tag="BSU05520" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein, sporulation-related" /protein_id="NP_388433.1" /db_xref="EnsemblGenomes-Gn:BSU05520" /db_xref="EnsemblGenomes-Tr:CAB12359" /db_xref="InterPro:IPR019618" /db_xref="SubtiList:BG12810" /db_xref="UniProtKB/Swiss-Prot:O31496" /translation="MRSQINISNLTINGMTQNANTDIGQNLQNSHTANSKNYGVNFTL GDYSPSHSIIISASCDNDTSDQGQVDNPSSPSEE*" /label="ydzH CDS" gene complement(560164..560400) /gene="ydzH" /locus_tag="BSU_05520" /old_locus_tag="BSU05520" /label="ydzH gene" downshifts complement(560188) /Source="Nicolas_upshifts" /id="D264" /incds=0 /nref=1 /ntot=10 /MaxReadThrough="3.87679" /MaxDrop="2.5881" /score="9.38580075" /energy="-6" /TU="NA" /idTUdmin="U430" /TUdmin=418 /isTUend="FALSE" /label="downshifts" promotor_-35 560212..560218 /Source="Nicolas_upshift_promotors" /id="U429" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.722277722277722" /psig="0.722277722277722" /xcortree=1208 /SigmaFactorBS="aagggttatcaacctgcccttgatcactTGTATCAttatcac aacttgcTGAAATAATAATtgaatgagaaggagagtaatctcctaatgtgaaattcac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 560233..560244 /Source="Nicolas_upshift_promotors" /id="U429" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.722277722277722" /psig="0.722277722277722" /xcortree=1208 /SigmaFactorBS="aagggttatcaacctgcccttgatcactTGTATCAttatcac aacttgcTGAAATAATAATtgaatgagaaggagagtaatctcctaatgtgaaattcac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 560244 /Source="Nicolas_upshifts" /id="U429" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.722277722277722" /psig="0.722277722277722" /xcortree=1208 /SigmaFactorBS="aagggttatcaacctgcccttgatcactTGTATCAttatcac aacttgcTGAAATAATAATtgaatgagaaggagagtaatctcctaatgtgaaattcac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(560401..560562) /Source="Nicolas_S_feature" /locus_tag="new_599344_599505_c" /HighExp="BT, B36, S8, S7, G135, S5, S6, G180, Pyr, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S192" S_feature complement(560566..560931) /Source="Nicolas_S_feature" /locus_tag="new_599509_599874_c" /HighExp="BT, B36, S8, S7, S6, G/S, S5, Pyr, B60, S4" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigGF, SigK" /TUshortPSig="0.994, 0.989, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S193" downshifts complement(560606) /Source="Nicolas_upshifts" /id="D265" /incds=0 /nref=26 /ntot=52 /MaxReadThrough="2.64253" /MaxDrop="4.6761" /score="8.29803249" /energy="-12.4" /TU="NA" /idTUdmin="U430" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(560932..561162) /gene="ydzR" /locus_tag="BSU_05529" /old_locus_tag="BSU05529" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 19383706, 20709900" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein, sporulation-related" /protein_id="YP_003097687.1" /db_xref="EnsemblGenomes-Gn:BSU05529" /db_xref="EnsemblGenomes-Tr:CAX52560" /db_xref="InterPro:IPR019618" /db_xref="UniProtKB/Swiss-Prot:C0H3W2" /translation="MMKFPVYIHSISGNSVFNNGFAVSISPFSVSKTTEGSGGSNTGL VFESNALSQTSSANQAQNVTYAIQELLSKLLA*" /label="ydzR CDS" gene complement(560932..561162) /gene="ydzR" /locus_tag="BSU_05529" /old_locus_tag="BSU05529" /label="ydzR gene" downshifts 561146 /Source="Nicolas_upshifts" /id="D266" /incds=0 /nref=1 /ntot=4 /MaxReadThrough="1.08051" /MaxDrop="3.36374" /score="17.861178" /energy="-6" /TU="NA" /idTUdmin="U428" /TUdmin=1034 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(561183..561202) /Source="Nicolas_upshift_promotors" /id="U430" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1432 /SigmaFactorBS="ggtttttgtctcttactgaaagtttttgccgttttGTTTAAG CAActgctgctcacacACCATATTGTATAAACAGTCataacagagaggagagatgaat g" /listShort="ydzR, S193" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(561200) /Source="Nicolas_upshifts" /id="U430" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1432 /SigmaFactorBS="ggtttttgtctcttactgaaagtttttgccgttttGTTTAAG CAActgctgctcacacACCATATTGTATAAACAGTCataacagagaggagagatgaat g" /listShort="ydzR, S193" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(561202..561285) /Source="Nicolas_S_feature" /locus_tag="new_600145_600228_c" /HighExp="S8, S5, S7, S6, S4, nit, ferm, BT, Pyr, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigK" /TUshortPSig="0.989, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S194" promotor_-35 complement(561216..561225) /Source="Nicolas_upshift_promotors" /id="U430" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1432 /SigmaFactorBS="ggtttttgtctcttactgaaagtttttgccgttttGTTTAAG CAActgctgctcacacACCATATTGTATAAACAGTCataacagagaggagagatgaat g" /listShort="ydzR, S193" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(561286..561963) /gene="ydfR" /locus_tag="BSU_05530" /old_locus_tag="BSU05530" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="NP_388434.1" /db_xref="EnsemblGenomes-Gn:BSU05530" /db_xref="EnsemblGenomes-Tr:CAB12360" /db_xref="GOA:P96696" /db_xref="InterPro:IPR007353" /db_xref="InterPro:IPR023090" /db_xref="SubtiList:BG12165" /db_xref="UniProtKB/Swiss-Prot:P96696" /translation="MNRLPFGYIKLRLAGRKANPMTNLIHHWSGGSMNFTWESLVLIV AGVILLRISGRKSIAQMTSTQTVVMISIGTIIVQPIIEYSLFKTLIAAAIFTSTLIVM EWIQMKSNTIEKMLTGKAKIVIENGQLHIENLKKMRLTADQLEMQLRLHGVTAIQDVK IATLEANGQLGIELTDDAKPLTVRDLKKLIHPDFINKDGQAQSGNQNIFDEVGKKNKK NVPKKLH*" /label="ydfR CDS" gene complement(561286..561963) /gene="ydfR" /locus_tag="BSU_05530" /old_locus_tag="BSU05530" /label="ydfR gene" promotor_-10 complement(561934..561945) /Source="Nicolas_upshift_promotors" /id="U431" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=782 /SigmaFactorBS="taatatatccatctataccaaaaatattgttcggttcaggac AGAATGAaccgactgcctttcGGATATATTAAAttgcgattggccggaagaaaagcca a" /listShort="ydfR, S194, ydzR, S193" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(561948) /Source="Nicolas_upshifts" /id="U431" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=782 /SigmaFactorBS="taatatatccatctataccaaaaatattgttcggttcaggac AGAATGAaccgactgcctttcGGATATATTAAAttgcgattggccggaagaaaagcca a" /listShort="ydfR, S194, ydzR, S193" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(561960..561966) /Source="Nicolas_upshift_promotors" /id="U431" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=782 /SigmaFactorBS="taatatatccatctataccaaaaatattgttcggttcaggac AGAATGAaccgactgcctttcGGATATATTAAAttgcgattggccggaagaaaagcca a" /listShort="ydfR, S194, ydzR, S193" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(561964..562797) /Source="Nicolas_S_feature" /locus_tag="new_600907_601740_c" /HighExp="S6, S8, S7, S5, BT, B36, G/S, Pyr, nit, B60" /AntisenseName="ydfS" /AntisenseCor="0.65823831974361602" /AntisenseRegPval="-34.1" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S195" promotor_-35 561979..561984 /Source="Nicolas_upshift_promotors" /id="U432" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.944055944055944" /psig="0.944055944055944" /xcortree=781 /SigmaFactorBS="ccgaaaggcagtcggttcattctgtcctgaaccgaACAATAt ttttggtatagatGGATATATTAAGccaaacaatgatagcaacaggagttttttggcc g" /listShort="ydfS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 561999..562010 /Source="Nicolas_upshift_promotors" /id="U432" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.944055944055944" /psig="0.944055944055944" /xcortree=781 /SigmaFactorBS="ccgaaaggcagtcggttcattctgtcctgaaccgaACAATAt ttttggtatagatGGATATATTAAGccaaacaatgatagcaacaggagttttttggcc g" /listShort="ydfS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 562004 /Source="Nicolas_upshifts" /id="U432" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.944055944055944" /psig="0.944055944055944" /xcortree=781 /SigmaFactorBS="ccgaaaggcagtcggttcattctgtcctgaaccgaACAATAt ttttggtatagatGGATATATTAAGccaaacaatgatagcaacaggagttttttggcc g" /listShort="ydfS" /GFF_Attribute="listLong" /label="upshifts" CDS 562076..562783 /gene="ydfS" /locus_tag="BSU_05540" /old_locus_tag="BSU05540" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388435.1" /db_xref="EnsemblGenomes-Gn:BSU05540" /db_xref="EnsemblGenomes-Tr:CAB12361" /db_xref="GOA:P96697" /db_xref="InterPro:IPR007353" /db_xref="InterPro:IPR023090" /db_xref="SubtiList:BG12166" /db_xref="UniProtKB/Swiss-Prot:P96697" /translation="MIELEVVIRTVASFGLLLIAERILGKQTISQMTIFDFIAAITLG AIAAGLAYNTSIKPHNMAISFSIFVLTIFLISFLSIKNRKLRKFFAGDPTVLIQNGKI LESNMRKMRYTLDYLNQQLREKEIFNIEEVLFAILETNGQLTVLRKPQFRHVTKQDLM IAVNQEQRLPIELIMDGEIIENNLKQNRLTESWLLEELRKRDIKVKETVYAVLLGNGD IYVDQYKDHISVPMDKE*" /label="ydfS CDS" gene 562076..562783 /gene="ydfS" /locus_tag="BSU_05540" /old_locus_tag="BSU05540" /label="ydfS gene" CDS complement(562798..563229) /gene="cotP" /locus_tag="BSU_05550" /old_locus_tag="BSU05550" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11150673" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11150673; Product type s: structure" /codon_start=1 /transl_table=11 /product="spore coat protein" /protein_id="NP_388436.1" /db_xref="EnsemblGenomes-Gn:BSU05550" /db_xref="EnsemblGenomes-Tr:CAB12362" /db_xref="GOA:P96698" /db_xref="InterPro:IPR002068" /db_xref="InterPro:IPR008978" /db_xref="InterPro:IPR031107" /db_xref="SubtiList:BG12167" /db_xref="UniProtKB/Swiss-Prot:P96698" /translation="MDFEKIRKWLEITNEYKQSDFWTNVLKYKAPEHFFDSEASTFVY DFYQDEEYNFIIVEMPGVYEEELTIRLLSKTQLLIKGTITPVFPAEMEVLRERYYGEI ERIIQLPEAAETHLLQIQLLNGLLHISYPRQVETVAFNKGL*" /label="cotP CDS" gene complement(562798..563229) /gene="cotP" /locus_tag="BSU_05550" /old_locus_tag="BSU05550" /label="cotP gene" CDS complement(563242..563484) /gene="ydgA" /locus_tag="BSU_05560" /old_locus_tag="BSU05560" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; putative germination protein" /protein_id="NP_388437.1" /db_xref="EnsemblGenomes-Gn:BSU05560" /db_xref="EnsemblGenomes-Tr:CAB12363" /db_xref="InterPro:IPR019618" /db_xref="SubtiList:BG12168" /db_xref="UniProtKB/Swiss-Prot:P96699" /translation="MPYQINIANIKINGVTQNGNIDVGPTVHNSHTANSKYFGANFSL GDLSPTSSLLNTGNIDSDVSDQDQIGNPSAPISNQI*" /label="ydgA CDS" gene complement(563242..563484) /gene="ydgA" /locus_tag="BSU_05560" /old_locus_tag="BSU05560" /label="ydgA gene" CDS complement(563498..563770) /gene="ydgB" /locus_tag="BSU_05570" /old_locus_tag="BSU05570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; putative germination protein" /protein_id="NP_388438.1" /db_xref="EnsemblGenomes-Gn:BSU05570" /db_xref="EnsemblGenomes-Tr:CAB12364" /db_xref="InterPro:IPR019618" /db_xref="SubtiList:BG12169" /db_xref="UniProtKB/Swiss-Prot:P96700" /translation="MPSTVINLYYLKINSISGNGSITIGEAAYNSPTNNQKSQGTNSS FGDTSPTESVMENFLNDPDVNDQTSIGNSDTSNVNAPPIAPPPILD*" /label="ydgB CDS" gene complement(563498..563770) /gene="ydgB" /locus_tag="BSU_05570" /old_locus_tag="BSU05570" /label="ydgB gene" promotor_-10 complement(563792..563811) /Source="Nicolas_upshift_promotors" /id="U433" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1305 /SigmaFactorBS="gatagagttttgcccgtaaatgCAAGGAACAAttgggtgcag cggCGCATAATGTACTGTACAGAaagatggaagggtgtgatgggatgccgtctacagt a" /listShort="ydgB, ydgA, cotP, S195, ydfR, S194, ydzR, S193" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(563796) /Source="Nicolas_upshifts" /id="U433" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1305 /SigmaFactorBS="gatagagttttgcccgtaaatgCAAGGAACAAttgggtgcag cggCGCATAATGTACTGTACAGAaagatggaagggtgtgatgggatgccgtctacagt a" /listShort="ydgB, ydgA, cotP, S195, ydfR, S194, ydzR, S193" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(563825..563834) /Source="Nicolas_upshift_promotors" /id="U433" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1305 /SigmaFactorBS="gatagagttttgcccgtaaatgCAAGGAACAAttgggtgcag cggCGCATAATGTACTGTACAGAaagatggaagggtgtgatgggatgccgtctacagt a" /listShort="ydgB, ydgA, cotP, S195, ydfR, S194, ydzR, S193" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 563989..563996 /Source="Nicolas_upshift_promotors" /id="U434" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.786213786213786" /psig="0.997002997002997" /xcortree=1917 /SigmaFactorBS="gaagctggcaaacaggatcagtttgaaatAATTGACAatgaa gctaatgccaTGAAATAATACTCGTGAGTAacattactcgtgggtattatttttgggg t" /listShort="ydgC, ydgD, S196, ydgE, S197" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 564012..564031 /Source="Nicolas_upshift_promotors" /id="U434" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.786213786213786" /psig="0.997002997002997" /xcortree=1917 /SigmaFactorBS="gaagctggcaaacaggatcagtttgaaatAATTGACAatgaa gctaatgccaTGAAATAATACTCGTGAGTAacattactcgtgggtattatttttgggg t" /listShort="ydgC, ydgD, S196, ydgE, S197" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 564020 /Source="Nicolas_upshifts" /id="U434" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.786213786213786" /psig="0.997002997002997" /xcortree=1917 /SigmaFactorBS="gaagctggcaaacaggatcagtttgaaatAATTGACAatgaa gctaatgccaTGAAATAATACTCGTGAGTAacattactcgtgggtattatttttgggg t" /listShort="ydgC, ydgD, S196, ydgE, S197" /GFF_Attribute="listLong" /label="upshifts" CDS 564069..564656 /gene="ydgC" /locus_tag="BSU_05580" /old_locus_tag="BSU05580" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_388439.1" /db_xref="EnsemblGenomes-Gn:BSU05580" /db_xref="EnsemblGenomes-Tr:CAB12365" /db_xref="GOA:P96701" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036271" /db_xref="SubtiList:BG12170" /db_xref="UniProtKB/Swiss-Prot:P96701" /translation="MKSKGVESRKRLLKAAANEFSVRGFHDAKVSEIVKKAGFTQPSF YLYFQSKEAIFAELITDFHSRVRKLTESLLLENGLNTEDVSKRVLLAVETVFQFLDED KDLTKIGFFLNPEAKQMKKDLAMVLKENLEAEQRLGYFHSELDMETVAECLVGMIEHL TESFLLTGIKDPASLAAEVVNLLIYGMLPKGNDVR*" /label="ydgC CDS" gene 564069..564656 /gene="ydgC" /locus_tag="BSU_05580" /old_locus_tag="BSU05580" /label="ydgC gene" CDS 564653..564997 /gene="ydgD" /locus_tag="BSU_05590" /old_locus_tag="BSU05590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388440.1" /db_xref="EnsemblGenomes-Gn:BSU05590" /db_xref="EnsemblGenomes-Tr:CAB12366" /db_xref="GOA:P96702" /db_xref="InterPro:IPR032808" /db_xref="SubtiList:BG12171" /db_xref="UniProtKB/Swiss-Prot:P96702" /translation="MISIMMKVSLAVFMLAGGIIKVSRVPFQVEHWRHYQYPLWFLTV TGILEIAGALAMTAGIWNRYAAIGAGVLFVVLMAGAIHAHMFRARQSVIMAIQAMICL IVSIMIIMGSYT*" /label="ydgD CDS" gene 564653..564997 /gene="ydgD" /locus_tag="BSU_05590" /old_locus_tag="BSU05590" /label="ydgD gene" S_feature 564998..565159 /Source="Nicolas_S_feature" /locus_tag="new_603941_604102" /HighExp="Salt, Diami, dia15, dia5, aero, H2O2, SMMPr, Etha, Lbtran, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S196" CDS 565160..565633 /gene="ydgE" /locus_tag="BSU_05600" /old_locus_tag="BSU05600" /EC_number="2.3.1.-" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_388441.1" /db_xref="EnsemblGenomes-Gn:BSU05600" /db_xref="EnsemblGenomes-Tr:CAB12367" /db_xref="GOA:P96703" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG12172" /db_xref="UniProtKB/Swiss-Prot:P96703" /translation="MAFTLEDMTEEEFEAFRGMSVQNFAKQNITSGTWTEKEAFEKSE QAYENMIPNGRDSSNHYFWNITNDQGERMGWLWLYADPLHPQKEAFIYSFGLYEAFRG KGLAQLALQTLDERARELGAERLALHVFAHNETAVYLYQKMGYAMTNIRMRKQLC*" /label="ydgE CDS" gene 565160..565633 /gene="ydgE" /locus_tag="BSU_05600" /old_locus_tag="BSU05600" /label="ydgE gene" S_feature 565634..566326 /Source="Nicolas_S_feature" /locus_tag="new_604577_605269" /HighExp="Salt, H2O2, dia15, aero, T-2.40H, Diami, T-3.40H, T-1.40H, T-4.40H, T-0.40H" /AntisenseName="vmlR" /AntisenseCor="-7.1224465259194999E-2" /AntisenseRegPval="-0.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S197" downshifts complement(565776) /Source="Nicolas_upshifts" /id="D267" /incds=0 /nref=4 /ntot=88 /MaxReadThrough="0.39199" /MaxDrop="3.39645" /score="18.2783449" /energy="-8.8" /TU="NA" /idTUdmin="U436" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(565793..567436) /gene="vmlR" /locus_tag="BSU_05610" /old_locus_tag="BSU05610" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16109936, 22226636, 24687494, 25891423" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16109936, 22226636, 24687494, 25891423; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ATP-binding cassette efflux transporter" /protein_id="NP_388442.1" /db_xref="EnsemblGenomes-Gn:BSU05610" /db_xref="EnsemblGenomes-Tr:CAB12368" /db_xref="GOA:P39115" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR032781" /db_xref="SubtiList:BG10767" /db_xref="UniProtKB/Swiss-Prot:P39115" /translation="MKEIVTLTNVSYEVKDQTVFKHVNASVQQGDIIGIIGKNGAGKS TLLHLIHNDLAPAQGQILRKDIKLALVEQETAAYSFADQTPAEKKLLEKWHVPLRDFH QLSGGEKLKARLAKGLSEDADLLLLDEPTNHLDEKSLQFLIQQLKHYNGTVILVSHDR YFLDEAATKIWSLEDQTLIEFKGNYSGYMKFREKKRLTQQREYEKQQKMVERIEAQMN GLASWSEKAHAQSTKKEGFKEYHRVKAKRTDAQIKSKQKRLEKELEKAKAEPVTPEYT VRFSIDTTHKTGKRFLEVQNVTKAFGERTLFKNANFTIQHGEKVAIIGPNGSGKTTLL NIILGQETAEGSVWVSPSANIGYLTQEVFDLPLEQTPEELFENETFKARGHVQNLMRH LGFTAAQWTEPIKHMSMGERVKIKLMAYILEEKDVLILDEPTNHLDLPSREQLEETLS QYSGTLLAVSHDRYFLEKTTNSKLVISNNGIEKQLNDVPSERNEREELRLKLETERQE VLGKLSFMTPNDKGYKELDQAFNELTKRIKELDHQDKKD*" /label="vmlR CDS" gene complement(565793..567436) /gene="vmlR" /locus_tag="BSU_05610" /old_locus_tag="BSU05610" /label="vmlR gene" S_feature complement(567471..567668) /Source="Nicolas_S_feature" /locus_tag="new_606414_606611_c" /HighExp="BC, Sw, B60, B36, LoTm, S7, HiOs, S4, BI, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S198" promotor_-35 567485..567487 /Source="Nicolas_upshift_promotors" /id="U435" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.433566433566434" /psig="0.494505494505494" /xcortree=34 /SigmaFactorBS="gctttaaagggagaataaaaaaatcctcccaaatgtgTTGga aggattagccgtgcCTGTGCATGATCAAATAAGctattttttataaatagcagtgtcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 567504..567522 /Source="Nicolas_upshift_promotors" /id="U435" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.433566433566434" /psig="0.494505494505494" /xcortree=34 /SigmaFactorBS="gctttaaagggagaataaaaaaatcctcccaaatgtgTTGga aggattagccgtgcCTGTGCATGATCAAATAAGctattttttataaatagcagtgtcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 567508 /Source="Nicolas_upshifts" /id="U435" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.433566433566434" /psig="0.494505494505494" /xcortree=34 /SigmaFactorBS="gctttaaagggagaataaaaaaatcctcccaaatgtgTTGga aggattagccgtgcCTGTGCATGATCAAATAAGctattttttataaatagcagtgtcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(567514) /Source="Nicolas_upshifts" /id="D268" /incds=0 /nref=210 /ntot=265 /MaxReadThrough="3.59768" /MaxDrop="6.27457" /score="29.5863709" /energy="-11.8" /TU="U436" /idTUdmin="U437" /TUdmin=242 /isTUend="FALSE" /label="downshifts" downshifts 567634 /Source="Nicolas_upshifts" /id="D269" /incds=0 /nref=35 /ntot=150 /MaxReadThrough="1.71902" /MaxDrop="4.95368" /score="-7.23582918" /energy="-13.3" /TU="NA" /idTUdmin="U435" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(567660..567679) /Source="Nicolas_upshift_promotors" /id="U436" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.717282717282717" /psig=1 /xcortree=414 /SigmaFactorBS="atgagagcaggagtttttttgatgaaaatgaccTTTGCTTTt gaatttaaaggTATGCTATAGTGTTTGTAATcaaaacaagaagggatgatgggtggac a" /listShort="S198, vmlR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(567672) /Source="Nicolas_upshifts" /id="U436" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.717282717282717" /psig=1 /xcortree=414 /SigmaFactorBS="atgagagcaggagtttttttgatgaaaatgaccTTTGCTTTt gaatttaaaggTATGCTATAGTGTTTGTAATcaaaacaagaagggatgatgggtggac a" /listShort="S198, vmlR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(567692..567699) /Source="Nicolas_upshift_promotors" /id="U436" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.717282717282717" /psig=1 /xcortree=414 /SigmaFactorBS="atgagagcaggagtttttttgatgaaaatgaccTTTGCTTTt gaatttaaaggTATGCTATAGTGTTTGTAATcaaaacaagaagggatgatgggtggac a" /listShort="S198, vmlR" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(567755) /Source="Nicolas_upshifts" /id="D270" /incds=0 /nref=92 /ntot=203 /MaxReadThrough="2.22553" /MaxDrop="5.71399" /score="18.9878298" /energy="-13.3" /TU="NA" /idTUdmin="U437" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(567756..569132) /gene="ydgF" /locus_tag="BSU_05620" /old_locus_tag="BSU05620" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16109936, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative amino acid permease" /protein_id="NP_388443.1" /db_xref="EnsemblGenomes-Gn:BSU05620" /db_xref="EnsemblGenomes-Tr:CAB12369" /db_xref="GOA:P96704" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG12173" /db_xref="UniProtKB/Swiss-Prot:P96704" /translation="MTDDMTKDNINQQTLQRGLKNRHIQLIAIGGAIGTGLFLGSGKS IHFAGPSILFAYMITGIICFLIMRSLGELLLSNLNYHSFVDFVQDYLGDMAAFITGWT YWFCWISIAMADLTAVGLYTQYWLPGVPQWVPGLIALIILLIMNLATVKLFGELEFWF ALIKVIAILALIVIGLVMIFKGFSTSSGVSSFTNLWSHGGLFPNGMHGFILSFQMVVF AFVGIELVGLTAGETENPEKVIPKAINNIPVRVLLFYIGALLVIMSIYPWDIINPSES PFVQVFVAVGIVGAASIINFVVLTSAASACNSAVFSTSRMVYSLAKDHNAPESMAKLT QRKVPRNALFFSAIVILIGVTLNYIMPEGVFTLITSISTVCFIYIWGITVICHMKYRK TRPELAKTNKFKLPLYPFTNYLILAFLAFVLVVLALAQDTRVSLFVTPVWFILLIVIY KVRKAKHQ*" /label="ydgF CDS" gene complement(567756..569132) /gene="ydgF" /locus_tag="BSU_05620" /old_locus_tag="BSU05620" /label="ydgF gene" misc_feature complement(569182..569201) /Source="Nicolas_upshift_promotors" /id="U437" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.897102897102897" /psig=1 /xcortree=1890 /SigmaFactorBS="aatcacattaaaattcttttcatcaatccttttttagtaaaa aagatagaaattttAGTGTTATAATAATCATTAAaaatagattgctgactcaataaac a" /listShort="ydgF" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(569197) /Source="Nicolas_upshifts" /id="U437" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.897102897102897" /psig=1 /xcortree=1890 /SigmaFactorBS="aatcacattaaaattcttttcatcaatccttttttagtaaaa aagatagaaattttAGTGTTATAATAATCATTAAaaatagattgctgactcaataaac a" /listShort="ydgF" /GFF_Attribute="listLong" /label="upshifts" Polymorphism join(569271,569273) /Source="geneious" /ID="SNP_BsDelta6_608215_608214" /Polymorphism_Type="Insertion (tandem repeat)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=0 /Amino_Acid_Change /CDS_Position /Change="(A)5 -> (A)6" /Codon_Change /Coverage=41 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides /Variant_Nucleotides="A" /Variant_P_Value="8.2e-115" /Variant_Raw_Frequency=39 /comment="dinB_terminator_improvement" /modified_by="User" / /label="Polymorphism_Delta6" terminator 569272..569305 /created_by="User" /comment="dinB_terminator_improvement" /modified_by="User" /label="Delta6_dinB_Terminator" CDS complement(569304..569822) /gene="dinB" /locus_tag="BSU_05630" /old_locus_tag="BSU05630" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 1847907, 3110138, 12644484, 16267290, 22059487; Product type r: regulator" /codon_start=1 /transl_table=11 /product="nuclease inhibitor" /protein_id="NP_388444.1" /db_xref="EnsemblGenomes-Gn:BSU05630" /db_xref="EnsemblGenomes-Tr:CAB12370" /db_xref="GOA:Q02886" /db_xref="InterPro:IPR007837" /db_xref="InterPro:IPR034660" /db_xref="SubtiList:BG10539" /db_xref="UniProtKB/Swiss-Prot:Q02886" /translation="MSDFAFKLYEYNVWANQQIFNRLKELPKEIYHQEIQSVFPSISH VLSHVYLSDLGWIEVFSGKTLSDALALAEQLKEQTEAKEIEEMEDLFLRLSERYILFL QQKEQLNKPLQIQNPSSGIMKTTVSELLPHVVNHGTYHRGNITAMLRQAGYASAPTDY GLYLFMTKTEKA*" /label="dinB CDS" gene complement(569304..569822) /gene="dinB" /locus_tag="BSU_05630" /old_locus_tag="BSU05630" /label="dinB gene" downshifts complement(569318) /Source="Nicolas_upshifts" /id="D271" /incds=0 /nref=35 /ntot=176 /MaxReadThrough="2.77148" /MaxDrop="6.32316" /score="16.2748201" /energy="-15" /TU="NA" /idTUdmin="U438" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(569848..569867) /Source="Nicolas_upshift_promotors" /id="U438" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.839160839160839" /psig=1 /xcortree=1506 /SigmaFactorBS="tcctctaaactatatatgtcaacaaattttattttcgagcaC TCTacataagaactcatgTTCGTGTATAATGAAAGCTAtacacacgaaagggggaatt t" /listShort="dinB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(569867) /Source="Nicolas_upshifts" /id="U438" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.839160839160839" /psig=1 /xcortree=1506 /SigmaFactorBS="tcctctaaactatatatgtcaacaaattttattttcgagcaC TCTacataagaactcatgTTCGTGTATAATGAAAGCTAtacacacgaaagggggaatt t" /listShort="dinB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(569883..569886) /Source="Nicolas_upshift_promotors" /id="U438" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.839160839160839" /psig=1 /xcortree=1506 /SigmaFactorBS="tcctctaaactatatatgtcaacaaattttattttcgagcaC TCTacataagaactcatgTTCGTGTATAATGAAAGCTAtacacacgaaagggggaatt t" /listShort="dinB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 569904..569911 /Source="Nicolas_upshift_promotors" /id="U439" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig="0.97002997002997" /xcortree=2440 /SigmaFactorBS="gagtgctcgaaaataaaattTGTTGACAtatatagtttagag GAATAAACTAATTGACATTGaacataaagtttagcggggtaaactataatgaggaggg g" /listShort="ydgG, ydgH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 569926..569945 /Source="Nicolas_upshift_promotors" /id="U439" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig="0.97002997002997" /xcortree=2440 /SigmaFactorBS="gagtgctcgaaaataaaattTGTTGACAtatatagtttagag GAATAAACTAATTGACATTGaacataaagtttagcggggtaaactataatgaggaggg g" /listShort="ydgG, ydgH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 569944 /Source="Nicolas_upshifts" /id="U439" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig="0.97002997002997" /xcortree=2440 /SigmaFactorBS="gagtgctcgaaaataaaattTGTTGACAtatatagtttagag GAATAAACTAATTGACATTGaacataaagtttagcggggtaaactataatgaggaggg g" /listShort="ydgG, ydgH" /GFF_Attribute="listLong" /label="upshifts" CDS 569991..570449 /gene="ydgG" /locus_tag="BSU_05640" /old_locus_tag="BSU05640" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MarR family)" /protein_id="NP_388445.1" /db_xref="EnsemblGenomes-Gn:BSU05640" /db_xref="EnsemblGenomes-Tr:CAB12371" /db_xref="GOA:P96705" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12174" /db_xref="UniProtKB/Swiss-Prot:P96705" /translation="MNEQKLCQAINLFVEVLLEGTEFVHREINQDVFKHISREQADLL KILKVKGPTSPGSLAMYQNVHKSAISNRLKKLLEKGLVQWDDCPEKSDRRSKLINITP SGEHILEELDSAIFNALKPLIDDIDEEHLHSIIEIFTILKSKFKGGDSAE*" /label="ydgG CDS" gene 569991..570449 /gene="ydgG" /locus_tag="BSU_05640" /old_locus_tag="BSU05640" /label="ydgG gene" CDS 570446..573103 /gene="ydgH" /locus_tag="BSU_05650" /old_locus_tag="BSU05650" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15941986; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane component" /protein_id="NP_388446.1" /db_xref="EnsemblGenomes-Gn:BSU05650" /db_xref="EnsemblGenomes-Tr:CAB12372" /db_xref="GOA:P96706" /db_xref="InterPro:IPR000731" /db_xref="InterPro:IPR004869" /db_xref="SubtiList:BG12175" /db_xref="UniProtKB/Swiss-Prot:P96706" /translation="MRAIIKFKWAIAAIVLALTVVLSLFSPNLTELANQKGQAQLPAD AVSERANAILKQAGEDNNSISVVFTLDNAIKKETENQLRIIIDKIKKIDGVEEVTSPL SAEKEVKDQLMSKDKKTVLMPVTITGSDKKAEKIADEIYQIVPDDLTAYITGASLINQ DFAHSSEEGLKKTEVITVCLIIGLLLIVFRSVVTPFIPIVVVGFSYLISQSILGILVY NVDFPISTFTQTFLVAILFGIGTDYCILLLTRFREELANGHDKKEAALIAYRTGGKTL FISGFAVLIGFSALGFAKFAIFQSAVGVAVGVGILMIILYTLLPLFMVTLGEKLFWPS KKVLSHSDNKLWAFLGRHSVARPFLFIVITVVITLPFILTYDDQISFDSTAEISSDYK SIKALEAIKDGFGEGKAFPINVVVKGDKDLTTADTIPYLGNISKAIEKVDHVDSVMTI TQPTGKKIKDLYIDNQLGSVSDGLDKTVKGIADVQSGLTDIENGLNQMAGQTGSASNG GSGGSLGDAADGLGKINQQLQLVSKQISQTGNTAQTVQQLTAISGQLGQIQTGLEQAN QQLSGQQAQAGTLTESLKKLSEGVKSANEGLTKVSDGITASSDILEDMSKSPTVRDTG IFIPDQVMKDKDFKKSIDQYSFADGKGVQLSVVLDSNPYSEQAITTINQIKKAVANEV DGTPLENAQIVYGGVTSMNADLKELSTTDFSRTMVIMIIGLFIVLTILFRSMIMPIYM IASLLLTYYTSISITELIFVNGLGNAGVSWAVPFFSFVILIALGVDYSIFLLDRFKEE VHLGIEQGVVRSMSKMGSVIITAAIILAGTFAAMMPSGVNTLMQVASVIIIGLLLYGL VILPLFIPAIIATFGEGNWWPFGRKKGKE*" /label="ydgH CDS" gene 570446..573103 /gene="ydgH" /locus_tag="BSU_05650" /old_locus_tag="BSU05650" /label="ydgH gene" downshifts 573224 /Source="Nicolas_upshifts" /id="D272" /incds=0 /nref=3 /ntot=27 /MaxReadThrough="0.245049999999999" /MaxDrop="4.45167" /score="13.780898" /energy="-13.9" /TU="NA" /idTUdmin="U439" /TUdmin=22 /isTUend="TRUE" /label="downshifts" CDS complement(573249..573878) /gene="ydgI" /locus_tag="BSU_05660" /old_locus_tag="BSU05660" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 26415543; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="nitroreductase of unidentified specificity (reduces 5-(aziridin-1-yl)-2,4-dinitrobenzamide prodrug)" /protein_id="NP_388447.1" /db_xref="EnsemblGenomes-Gn:BSU05660" /db_xref="EnsemblGenomes-Tr:CAB12385" /db_xref="GOA:P96707" /db_xref="InterPro:IPR000415" /db_xref="InterPro:IPR029479" /db_xref="SubtiList:BG12176" /db_xref="UniProtKB/Swiss-Prot:P96707" /translation="MIKTNDFMEIMKGRRSIRNYDPAVKISKEEMTEILEEATTAPSS VNAQPWRFLVIDSPEGKEKLAPLASFNQTQVTTSSAVIAVFADMNNADYLEEIYSKAV ELGYMPQEVKDRQIAALTAHFEKLPAQVNRETILIDGGLVSMQLMLTARAHGYDTNPI GGYDKENIAETFGLDKERYVPVMLLSIGKAADEGYASYRLPIDTIAEWK*" /label="ydgI CDS" gene complement(573249..573878) /gene="ydgI" /locus_tag="BSU_05660" /old_locus_tag="BSU05660" /label="ydgI gene" downshifts complement(573253) /Source="Nicolas_upshifts" /id="D273" /incds=0 /nref=21 /ntot=184 /MaxReadThrough="2.66406" /MaxDrop="6.06581" /score="21.7451043" /energy="-16.6" /TU="NA" /idTUdmin="U440" /TUdmin=3 /isTUend="TRUE" /label="downshifts" CDS complement(573894..574388) /gene="ydgJ" /locus_tag="BSU_05670" /old_locus_tag="BSU05670" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MarR family)" /protein_id="NP_388448.1" /db_xref="EnsemblGenomes-Gn:BSU05670" /db_xref="EnsemblGenomes-Tr:CAB12386" /db_xref="GOA:P96708" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR001845" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12177" /db_xref="UniProtKB/Swiss-Prot:P96708" /translation="MTCQSLIYQLIVLTGKKGWVLASFCSEEAEILYQLQGVNKVIGV KFEACTGISQSRLELLTLLYHADEISQSDLQKKVNIDSAAVTRHLKQLESKGMVSRRR KPEDNRITLVRLTDQGRERIESSKKEKERFMKEMLANVSAEERRLLIDVLARMRNNIN NIEA*" /label="ydgJ CDS" gene complement(573894..574388) /gene="ydgJ" /locus_tag="BSU_05670" /old_locus_tag="BSU05670" /label="ydgJ gene" promotor_-10 complement(574380..574399) /Source="Nicolas_upshift_promotors" /id="U440" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=1967 /SigmaFactorBS="ttatgcgctgggaggttgttcaaaagtgcaaatggCTTGCAa gatgaaatcaatcgTTGTATATTAATTGACGTGTcaatcattgatatatcaattaata g" /listShort="ydgJ, ydgI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(574395) /Source="Nicolas_upshifts" /id="U440" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=1967 /SigmaFactorBS="ttatgcgctgggaggttgttcaaaagtgcaaatggCTTGCAa gatgaaatcaatcgTTGTATATTAATTGACGTGTcaatcattgatatatcaattaata g" /listShort="ydgJ, ydgI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(574415..574420) /Source="Nicolas_upshift_promotors" /id="U440" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=1967 /SigmaFactorBS="ttatgcgctgggaggttgttcaaaagtgcaaatggCTTGCAa gatgaaatcaatcgTTGTATATTAATTGACGTGTcaatcattgatatatcaattaata g" /listShort="ydgJ, ydgI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 574586..574588 /Source="Nicolas_upshift_promotors" /id="U441" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.786213786213786" /psig=1 /xcortree=2606 /SigmaFactorBS="ttcggaatatcactttgccggcccgtgctcaagcggCTTtca caggctgaaagtTATGATACAATATACAAATGtttcacagcttcaatccatagttgga g" /listShort="S199, ydgK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 574604..574623 /Source="Nicolas_upshift_promotors" /id="U441" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.786213786213786" /psig=1 /xcortree=2606 /SigmaFactorBS="ttcggaatatcactttgccggcccgtgctcaagcggCTTtca caggctgaaagtTATGATACAATATACAAATGtttcacagcttcaatccatagttgga g" /listShort="S199, ydgK" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 574610..574698 /Source="Nicolas_S_feature" /locus_tag="new_613552_613640" /HighExp="H2O2, G180, G135, Diami, Paraq, Oxctl, G150, LBGexp, LPh, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S199" upshifts 574610 /Source="Nicolas_upshifts" /id="U441" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.786213786213786" /psig=1 /xcortree=2606 /SigmaFactorBS="ttcggaatatcactttgccggcccgtgctcaagcggCTTtca caggctgaaagtTATGATACAATATACAAATGtttcacagcttcaatccatagttgga g" /listShort="S199, ydgK" /GFF_Attribute="listLong" /label="upshifts" CDS 574699..575907 /gene="ydgK" /locus_tag="BSU_05680" /old_locus_tag="BSU05680" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388449.1" /db_xref="EnsemblGenomes-Gn:BSU05680" /db_xref="EnsemblGenomes-Tr:CAB12387" /db_xref="GOA:P96709" /db_xref="InterPro:IPR004812" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12178" /db_xref="UniProtKB/Swiss-Prot:P96709" /translation="MLHNPTGKERLALAFLLGMLAILGPLNIDMYLPSFPEIAKDLSA SASLVQLSLTACLVGLTIGQLIVGPVSDAQGRRKPLLICIFLFALSSLFCALSPNITT LVAARFLQGFTASAGLVLSRAIVRDVFTGRELSKFFSLLMVITAVAPMVAPMTGGAIL LLPFATWHTIFHVLMIIGFLLVLLIALRLKETLPLEKRIPSSIGTSVKTMGSLLKDRS FMGYALTVGFIHGGSFAYVSGTPFVYQDIYGVSPQVFSILFGINGLAIISGSFIIGRF GGIIHEKSLLRIAVITAMIATAVLLTMTMIHGPLATLVISIFIYMITIGMVLTSTFTL AMEKQGHRAGSASALLGMLPLLLGSIVSPLVGINETTAVPMGAIMFVTAVIGSLAFFG LTKERVGQNS*" /label="ydgK CDS" gene 574699..575907 /gene="ydgK" /locus_tag="BSU_05680" /old_locus_tag="BSU05680" /label="ydgK gene" downshifts 575886 /Source="Nicolas_upshifts" /id="D274" /incds=0 /nref=23 /ntot=112 /MaxReadThrough="0.507390000000001" /MaxDrop="3.27202" /score="25.806679" /energy="-7.5" /TU="NA" /idTUdmin="U441" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(575943..576680) /gene="ydhB" /locus_tag="BSU_05690" /old_locus_tag="BSU05690" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388450.2" /db_xref="EnsemblGenomes-Gn:BSU05690" /db_xref="EnsemblGenomes-Tr:CAB12388" /db_xref="GOA:O05493" /db_xref="InterPro:IPR002781" /db_xref="SubtiList:BG12179" /db_xref="UniProtKB/Swiss-Prot:O05493" /translation="MLIILVMFLLGIILGFIGAGGAGFVIALLTLLFHIPIHTALGTS LAGMAFTSLSGAYSHYREGNIQMKIGLIVGGFAAVGSFFGAKLTSFIPADLLHYLTAG MLFLSAILILIRLFILKEKAQVNQSTLSTYTRAVILGIAAGVLSGTFGIGSAPFIQIG LMIMLNLSIRHSVGTTMLVIIPLAVGGGIGYITEGFVDYVLLVKVLVGTMCGAYVGAK FTNLMPKVVLKSAIFLTPAIAGLLLLF*" /label="ydhB CDS" gene complement(575943..576680) /gene="ydhB" /locus_tag="BSU_05690" /old_locus_tag="BSU05690" /label="ydhB gene" S_feature complement(576681..576819) /Source="Nicolas_S_feature" /locus_tag="new_615623_615761_c" /HighExp="T0.30H, T1.30H, T1.0H, T-0.40H, T2.0H, T0.0H, LBGstat, T2.30H, T-1.10H, T-1.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.108111" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S200" promotor_-10 complement(576807..576826) /Source="Nicolas_upshift_promotors" /id="U442" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.773226773226773" /psig="0.999000999001" /xcortree=1711 /SigmaFactorBS="atataacagatggtaatgggaagcaacaaactGCCTTGTCag atccctgaattTGAGGTACGATATGTTTGCTgaacgacggtcgacggactactggcaa c" /listShort="S200, ydhB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(576819) /Source="Nicolas_upshifts" /id="U442" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.773226773226773" /psig="0.999000999001" /xcortree=1711 /SigmaFactorBS="atataacagatggtaatgggaagcaacaaactGCCTTGTCag atccctgaattTGAGGTACGATATGTTTGCTgaacgacggtcgacggactactggcaa c" /listShort="S200, ydhB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(576840..576847) /Source="Nicolas_upshift_promotors" /id="U442" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.773226773226773" /psig="0.999000999001" /xcortree=1711 /SigmaFactorBS="atataacagatggtaatgggaagcaacaaactGCCTTGTCag atccctgaattTGAGGTACGATATGTTTGCTgaacgacggtcgacggactactggcaa c" /listShort="S200, ydhB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 576851..576858 /Source="Nicolas_upshift_promotors" /id="U443" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.947052947052947" /psig="0.999000999001" /xcortree=1978 /SigmaFactorBS="atcgtacctcaaattcagggatctgacaaggcagtTTGTTGC TtcccattaccatcTGTTATATGATTTTGATGAAgaaaagcccttgaatatattcaaa a" /listShort="ydhC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 576872..576891 /Source="Nicolas_upshift_promotors" /id="U443" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.947052947052947" /psig="0.999000999001" /xcortree=1978 /SigmaFactorBS="atcgtacctcaaattcagggatctgacaaggcagtTTGTTGC TtcccattaccatcTGTTATATGATTTTGATGAAgaaaagcccttgaatatattcaaa a" /listShort="ydhC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 576876 /Source="Nicolas_upshifts" /id="U443" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.947052947052947" /psig="0.999000999001" /xcortree=1978 /SigmaFactorBS="atcgtacctcaaattcagggatctgacaaggcagtTTGTTGC TtcccattaccatcTGTTATATGATTTTGATGAAgaaaagcccttgaatatattcaaa a" /listShort="ydhC" /GFF_Attribute="listLong" /label="upshifts" CDS 576929..577603 /gene="ydhC" /locus_tag="BSU_05700" /old_locus_tag="BSU05700" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (GntR family)" /protein_id="NP_388451.1" /db_xref="EnsemblGenomes-Gn:BSU05700" /db_xref="EnsemblGenomes-Tr:CAB12389" /db_xref="GOA:O05494" /db_xref="InterPro:IPR000485" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR008920" /db_xref="InterPro:IPR011711" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12180" /db_xref="UniProtKB/Swiss-Prot:O05494" /translation="MDDFKLDKPTPYYLQFYNQLKKMIFNGTFKPGERINETQLAKSF GVSRSPIREAMRLLEKDGLLKADDRNGFSITSLTAKDVDEIYKIRIPLEQLAVELVID EADEEELTILEKQLEETEKAIHNGTEDTEIIRLNQKFHELLVDFSHNRHLKNLLEHVN DLIHFCRILNYTGDHRAETILREHRRIFEEVKKKNKEAAKQHVLAHFNHDCEHLKHVL EEGKEN*" /label="ydhC CDS" gene 576929..577603 /gene="ydhC" /locus_tag="BSU_05700" /old_locus_tag="BSU05700" /label="ydhC gene" promotor_-35 577662..577667 /Source="Nicolas_upshift_promotors" /id="U444" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1131 /SigmaFactorBS="agcagaacccttggtatttttttatgtattcacCACATAtct aagaggccccgtTAATAAGATTTTATGATGGtttgactaacgaataatgggggttaaa t" /listShort="ydhD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 577683..577701 /Source="Nicolas_upshift_promotors" /id="U444" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1131 /SigmaFactorBS="agcagaacccttggtatttttttatgtattcacCACATAtct aagaggccccgtTAATAAGATTTTATGATGGtttgactaacgaataatgggggttaaa t" /listShort="ydhD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 577689 /Source="Nicolas_upshifts" /id="U444" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1131 /SigmaFactorBS="agcagaacccttggtatttttttatgtattcacCACATAtct aagaggccccgtTAATAAGATTTTATGATGGtttgactaacgaataatgggggttaaa t" /listShort="ydhD" /GFF_Attribute="listLong" /label="upshifts" CDS 577730..578992 /gene="spoL" /locus_tag="BSU_05710" /old_locus_tag="BSU05710" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11011148, 12177332; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore cortex lytic enzyme" /protein_id="NP_388452.2" /db_xref="EnsemblGenomes-Gn:BSU05710" /db_xref="EnsemblGenomes-Tr:CAB12390" /db_xref="GOA:O05495" /db_xref="InterPro:IPR001223" /db_xref="InterPro:IPR011583" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="PDB:3CZ8" /db_xref="SubtiList:BG12181" /db_xref="UniProtKB/Swiss-Prot:O05495" /translation="MFIHIVGPGDSLFSIGRRYGASVDQIRGVNGLDETNIVPGQALL IPLYVYTVQPRDTLTAIAAKAFVPLERLRAANPGISPNALQAGAKITIPSISNYIAGT LSFYVLRNPDLDRELINDYAPYSSSISIFEYHIAPNGDIANQLNDAAAIETTWQRRVT PLATITNLTSGGFSTEIVHQVLNNPTARTNLVNNIYDLVSTRGYGGVTIDFEQVSAAD RDLFTGFLRQLRDRLQAGGYVLTIAVPAKTSDNIPWLRGYDYGGIGAVVNYMFIMAYD WHHAGSEPGPVAPITEIRRTIEFTIAQVPSRKIIIGVPLYGYDWIIPYQPGTVASAIS NQNAIERAMRYQAPIQYSAEYQSPFFRYSDQQGRTHEVWFEDVRSMSRKMQIVREYRL QAIGAWQLTLGFTPGPWLLRKFFTIRKV*" /label="spoL CDS" gene 577730..578992 /gene="spoL" /locus_tag="BSU_05710" /old_locus_tag="BSU05710" /label="spoL gene" downshifts 578966 /Source="Nicolas_upshifts" /id="D275" /incds=0 /nref=33 /ntot=81 /MaxReadThrough="2.3134" /MaxDrop="5.20337" /score="15.7593331" /energy="-7.1" /TU="NA" /idTUdmin="U444" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 579064..579071 /Source="Nicolas_upshift_promotors" /id="U445" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.612387612387612" /psig="0.999000999001" /xcortree=1616 /SigmaFactorBS="taagtccagagcagcagaatagttcattcatttgtACCTTGC AtgggttgtgttccCATTTTACGATTAGTAGTAGtctgatcaaacaaagagtcagaat a" /listShort="ydhE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 579085..579104 /Source="Nicolas_upshift_promotors" /id="U445" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.612387612387612" /psig="0.999000999001" /xcortree=1616 /SigmaFactorBS="taagtccagagcagcagaatagttcattcatttgtACCTTGC AtgggttgtgttccCATTTTACGATTAGTAGTAGtctgatcaaacaaagagtcagaat a" /listShort="ydhE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 579089 /Source="Nicolas_upshifts" /id="U445" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.612387612387612" /psig="0.999000999001" /xcortree=1616 /SigmaFactorBS="taagtccagagcagcagaatagttcattcatttgtACCTTGC AtgggttgtgttccCATTTTACGATTAGTAGTAGtctgatcaaacaaagagtcagaat a" /listShort="ydhE" /GFF_Attribute="listLong" /label="upshifts" CDS 579153..580340 /gene="ydhE" /locus_tag="BSU_05720" /old_locus_tag="BSU05720" /function="18.1: Enzymes of unknown specificity" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20639339; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_388453.2" /db_xref="EnsemblGenomes-Gn:BSU05720" /db_xref="EnsemblGenomes-Tr:CAB12391" /db_xref="GOA:O05496" /db_xref="InterPro:IPR002213" /db_xref="InterPro:IPR006326" /db_xref="SubtiList:BG12182" /db_xref="UniProtKB/Swiss-Prot:O05496" /translation="MKTVLILNFPAEGHVNPTLGITKAFSDKGYDVHYISTEKYKKRL EAAGATVHLHRDLLRTTPIHVGSPNGILDFVKIHIKTSLDILQIVKDLSKSIQFDFVY YDKFGAGELVRDYLDIPGVSSSASFLFGEEHLKILPLHPESGAPLELDQECEDLLAKM KETYGVAPKNLVQFMNNKGELNVVYTSRYFQPESDRFGDECLFIGPSFPKRAEKTDFP IEQLKDEKVIYISMGTVLDHTEDFFNLCIDAFSGFNGKVVIAAGEKADLTKLKQAPEN FIIAPYVPQLEVLEQSDVFITHGGMNSVNEGIHFSVPLVVMPHDKDQPMVAQRLSELH AGYVISKDEVNAQILKQAVDEVLRNDQYTAGIKKINQSFKECMDMEEVMERIDELIRQ KNK*" /label="ydhE CDS" gene 579153..580340 /gene="ydhE" /locus_tag="BSU_05720" /old_locus_tag="BSU05720" /label="ydhE gene" downshifts 580352 /Source="Nicolas_upshifts" /id="D276" /incds=0 /nref=17 /ntot=224 /MaxReadThrough="1.77672" /MaxDrop="5.25325" /score="-6.36206618" /energy="-12.6" /TU="NA" /idTUdmin="U445" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(580379..581089) /gene="ydhF" /locus_tag="BSU_05730" /old_locus_tag="BSU05730" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10913081, 11557812; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative phosphate-starvation lipoprotein" /protein_id="NP_388454.1" /db_xref="EnsemblGenomes-Gn:BSU05730" /db_xref="EnsemblGenomes-Tr:CAB12392" /db_xref="InterPro:IPR029050" /db_xref="InterPro:IPR029051" /db_xref="SubtiList:BG12183" /db_xref="UniProtKB/Swiss-Prot:O05497" /translation="MRRILSILVFAIMLAGCSSNASTEKQHAGGEKTVKAEPQSTSSQ KDSTDDYQPNSQVTDDRTLHKVGQTFSDDKGKAVLKDIKQVNKTYKIGDVELTVKEMK LIHLRPDYSMIDYFHELTHDEEFDFVKVFVDIKNTSTKKVNVAPIALMKTNTGETFDW NKDIYLEELNGELEGGAEKSGNLGFIVNASSGHAHDKAADAEKKTKEIKWIEITTSDV FDHNHKKISDAQKIKIKF*" /label="ydhF CDS" gene complement(580379..581089) /gene="ydhF" /locus_tag="BSU_05730" /old_locus_tag="BSU05730" /label="ydhF gene" downshifts complement(580405) /Source="Nicolas_upshifts" /id="D277" /incds=0 /nref=11 /ntot=36 /MaxReadThrough="4.05808" /MaxDrop="4.7318" /score="13.7192471" /energy="-12.6" /TU="NA" /idTUdmin="U446" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(581155..582543) /gene="phoB" /locus_tag="BSU_05740" /old_locus_tag="BSU05740" /EC_number="3.1.3.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9335276, 10913081, 16030210, 16491025, 26382712, 27226549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9335276, 10913081, 16030210, 16491025, 26382712, 27226549; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="alkaline phosphatase III (promiscuous, heptaprenylglyceryl phosphate is a substrate)" /protein_id="NP_388455.2" /db_xref="EnsemblGenomes-Gn:BSU05740" /db_xref="EnsemblGenomes-Tr:CAB12393" /db_xref="GOA:P19405" /db_xref="InterPro:IPR001952" /db_xref="InterPro:IPR017849" /db_xref="InterPro:IPR017850" /db_xref="InterPro:IPR018299" /db_xref="SubtiList:BG10697" /db_xref="UniProtKB/Swiss-Prot:P19405" /translation="MKKFPKKLLPIAVLSSIAFSSLASGSVPEASAQEKKKGNQDEIK NVIVLIGDGMGVSYTSAYRYLKDNKKTKVVEPTAFDQYLVGQQTTYPDDPEQNVTDSA AAATAMSAGIKTYNNAIAVDNDGSEAKTVLEAAKEKGKATGLVATSEITHATPASFGS HDHSRKNMNSIADDYFDEMVNGKHKIDVLLGGGKSNFDRKDRNLIKEFKKAGYSYVDD RKDMLKNKDSQVLGLFADGGLPKKIDRTKDIPSLKDMTNTAIKKLNKDKDGFFLMVEG SQIDWAGHDNDIVGAMSEMEDFEQAYKAAIDFAKKDKHTLVVATADHSTGGYSIGADG IYNWFSEPIKAAKRTPDFMAEKIADGADVEKTLKTYIDQKKLALTKAEIQSVEEAAKS KEVLDIDNAIENIFNKRSHTGWTTGGHTGEDVPVYAYGPSSETFAGQIDNTEIAKNVF KALQYNIKINDK*" /label="phoB CDS" gene complement(581155..582543) /gene="phoB" /locus_tag="BSU_05740" /old_locus_tag="BSU05740" /label="phoB gene" promotor_-10 complement(582600..582617) /Source="Nicolas_upshift_promotors" /id="U446" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.982017982017982" /psig="0.011988011988012" /xcortree=9 /SigmaFactorBS="ggtgccagttcattattcttgtaaatccaaTCTTTAAAatcg atTAATACTAGCTTAACAGTttaaaaatataattgggttgtcattgagattcatctat a" /listShort="phoB, ydhF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(582601) /Source="Nicolas_upshifts" /id="U446" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.982017982017982" /psig="0.011988011988012" /xcortree=9 /SigmaFactorBS="ggtgccagttcattattcttgtaaatccaaTCTTTAAAatcg atTAATACTAGCTTAACAGTttaaaaatataattgggttgtcattgagattcatctat a" /listShort="phoB, ydhF" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(582603..582671) /Source="Nicolas_S_feature" /locus_tag="new_621545_621613_c" /HighExp="S6, S4, S5, S3, S7, LoTm, S8, T5.0H, B36, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S201" promotor_-35 complement(582624..582631) /Source="Nicolas_upshift_promotors" /id="U446" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.982017982017982" /psig="0.011988011988012" /xcortree=9 /SigmaFactorBS="ggtgccagttcattattcttgtaaatccaaTCTTTAAAatcg atTAATACTAGCTTAACAGTttaaaaatataattgggttgtcattgagattcatctat a" /listShort="phoB, ydhF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(582661..582679) /Source="Nicolas_upshift_promotors" /id="U447" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1157 /SigmaFactorBS="tattcctccaatttatttctttagtactatcgctctttcCTT CTAaaacttctcataaaaGAATAACCATTATTTAAGGgtgccagttcattattcttgt a" /listShort="S201, phoB, ydhF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(582679) /Source="Nicolas_upshifts" /id="U447" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1157 /SigmaFactorBS="tattcctccaatttatttctttagtactatcgctctttcCTT CTAaaacttctcataaaaGAATAACCATTATTTAAGGgtgccagttcattattcttgt a" /listShort="S201, phoB, ydhF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(582695..582700) /Source="Nicolas_upshift_promotors" /id="U447" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1157 /SigmaFactorBS="tattcctccaatttatttctttagtactatcgctctttcCTT CTAaaacttctcataaaaGAATAACCATTATTTAAGGgtgccagttcattattcttgt a" /listShort="S201, phoB, ydhF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 582748..582755 /Source="Nicolas_upshift_promotors" /id="U448" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.642357642357642" /psig="0.997002997002997" /xcortree=1887 /SigmaFactorBS="tagtactaaagaaataaattggaggaatagatactggCCGTG GATaggcggactgaaaTCTGCTATAGTCGCATAGAAgcaacccgcttacatcttgaac a" /listShort="S202, ydhG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 582769..582788 /Source="Nicolas_upshift_promotors" /id="U448" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.642357642357642" /psig="0.997002997002997" /xcortree=1887 /SigmaFactorBS="tagtactaaagaaataaattggaggaatagatactggCCGTG GATaggcggactgaaaTCTGCTATAGTCGCATAGAAgcaacccgcttacatcttgaac a" /listShort="S202, ydhG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 582771..582904 /Source="Nicolas_S_feature" /locus_tag="new_621713_621846" /HighExp="Diami, dia15, H2O2, Paraq, Oxctl, HPh, G180, G135, LPh, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S202" upshifts 582771 /Source="Nicolas_upshifts" /id="U448" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.642357642357642" /psig="0.997002997002997" /xcortree=1887 /SigmaFactorBS="tagtactaaagaaataaattggaggaatagatactggCCGTG GATaggcggactgaaaTCTGCTATAGTCGCATAGAAgcaacccgcttacatcttgaac a" /listShort="S202, ydhG" /GFF_Attribute="listLong" /label="upshifts" CDS 582905..583276 /gene="fra" /locus_tag="BSU_05750" /old_locus_tag="BSU05750" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:20087498, 21744456, 25826316" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20087498, 21744456, 25826316; Product type f: factor" /codon_start=1 /transl_table=11 /product="frataxin; iron/sulfur chaperone" /protein_id="NP_388456.1" /db_xref="EnsemblGenomes-Gn:BSU05750" /db_xref="EnsemblGenomes-Tr:CAB12394" /db_xref="GOA:Q797E6" /db_xref="InterPro:IPR014922" /db_xref="PDB:2OC6" /db_xref="SubtiList:BG12184" /db_xref="UniProtKB/Swiss-Prot:Q797E6" /translation="MDVFSEYLAGIADPFHRERTEEVLTWIKNKYPNLHTEIKWNQPM FTDHGTFIIGFSVSKKHLAVAPEKVTIAHVEDDIVKAGYDYTEQLIRIPWNGPVDYTL LEKMIEFNILDKADCSTFWRK*" /label="fra CDS" gene 582905..583276 /gene="fra" /locus_tag="BSU_05750" /old_locus_tag="BSU05750" /label="fra gene" downshifts 583255 /Source="Nicolas_upshifts" /id="D278" /incds=0 /nref=9 /ntot=150 /MaxReadThrough="2.88587" /MaxDrop="3.59127" /score="28.8500849" /energy="-8.1" /TU="NA" /idTUdmin="U448" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(583350) /Source="Nicolas_upshifts" /id="D279" /incds=0 /nref=9 /ntot=187 /MaxReadThrough="1.63268" /MaxDrop="2.98181" /score="0.51805655" /energy="-13" /TU="NA" /idTUdmin="U450" /TUdmin=2 /isTUend="TRUE" /label="downshifts" CDS complement(583351..583848) /gene="ydhH" /locus_tag="BSU_05760" /old_locus_tag="BSU05760" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388457.1" /db_xref="EnsemblGenomes-Gn:BSU05760" /db_xref="EnsemblGenomes-Tr:CAB12395" /db_xref="GOA:O05500" /db_xref="InterPro:IPR032545" /db_xref="SubtiList:BG12185" /db_xref="UniProtKB/Swiss-Prot:O05500" /translation="MSSHYKYPLIFTAFLLIAFCLIFFSYHLIHHVRLEYPNWQGESK DQNWEAVFTKNEDAPNEYSGKLYWIGDTIEIDNTYLESLIVKKDDEVLLSSDTEIPMH DYAGGTFSDGSAKEKSVSFLERLDEHELEGHDITIEVKWKQGNHYSASQLTLNEKTLF DEKQQ*" /label="ydhH CDS" gene complement(583351..583848) /gene="ydhH" /locus_tag="BSU_05760" /old_locus_tag="BSU05760" /label="ydhH gene" CDS complement(583866..584348) /gene="ydhI" /locus_tag="BSU_05770" /old_locus_tag="BSU05770" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_388458.1" /db_xref="EnsemblGenomes-Gn:BSU05770" /db_xref="EnsemblGenomes-Tr:CAB12396" /db_xref="GOA:O05501" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG12186" /db_xref="UniProtKB/Swiss-Prot:O05501" /translation="MMIIIPNNEIAKHMLTDFFAKHWGTPEMAISSGIFRCDELDGFA AVNESGEIIGCITYTIDGKDCEIISLDSMIENKGIGTALLQQVEEKAKHAHCQRIKLI TTNDNVNAIAFYQKRGYQFAAVFPNAVEKARRLKPEIPEVAENGILIRDEILFSKVID *" /label="ydhI CDS" gene complement(583866..584348) /gene="ydhI" /locus_tag="BSU_05770" /old_locus_tag="BSU05770" /label="ydhI gene" promotor_-35 584021..584028 /Source="Nicolas_upshift_promotors" /id="U449" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.767232767232767" /psig=1 /xcortree=2430 /SigmaFactorBS="gaattgatagcctctcttttgataaaacgctatcgCATTTAC AttatcattcgttgTGATAAGCTTTATTCGTTGAcaatgtgcatgtttagccttctct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 584042..584061 /Source="Nicolas_upshift_promotors" /id="U449" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.767232767232767" /psig=1 /xcortree=2430 /SigmaFactorBS="gaattgatagcctctcttttgataaaacgctatcgCATTTAC AttatcattcgttgTGATAAGCTTTATTCGTTGAcaatgtgcatgtttagccttctct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 584046 /Source="Nicolas_upshifts" /id="U449" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.767232767232767" /psig=1 /xcortree=2430 /SigmaFactorBS="gaattgatagcctctcttttgataaaacgctatcgCATTTAC AttatcattcgttgTGATAAGCTTTATTCGTTGAcaatgtgcatgtttagccttctct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(584377..584396) /Source="Nicolas_upshift_promotors" /id="U450" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.619380619380619" /psig="0.994005994005994" /xcortree=2264 /SigmaFactorBS="atatcgctgatttccatgccgtcacctcaacatCTATttttt ttgttatatATTGTTTATATTGATAGTACatatgcaatctttcaatagaggagtgtta t" /listShort="ydhI, ydhH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(584387) /Source="Nicolas_upshifts" /id="U450" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.619380619380619" /psig="0.994005994005994" /xcortree=2264 /SigmaFactorBS="atatcgctgatttccatgccgtcacctcaacatCTATttttt ttgttatatATTGTTTATATTGATAGTACatatgcaatctttcaatagaggagtgtta t" /listShort="ydhI, ydhH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(584411..584414) /Source="Nicolas_upshift_promotors" /id="U450" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.619380619380619" /psig="0.994005994005994" /xcortree=2264 /SigmaFactorBS="atatcgctgatttccatgccgtcacctcaacatCTATttttt ttgttatatATTGTTTATATTGATAGTACatatgcaatctttcaatagaggagtgtta t" /listShort="ydhI, ydhH" /GFF_Attribute="listLong" /label="promotor_-35" CDS 584431..585408 /gene="ydhJ" /locus_tag="BSU_05780" /old_locus_tag="BSU05780" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent phosphohydrolase" /protein_id="NP_388459.1" /db_xref="EnsemblGenomes-Gn:BSU05780" /db_xref="EnsemblGenomes-Tr:CAB12397" /db_xref="GOA:O05502" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR006674" /db_xref="SubtiList:BG12187" /db_xref="UniProtKB/Swiss-Prot:O05502" /translation="MEISDIIYGQHHIDGVLEELIKSAPVQRLKGIYQGGASFLVNRK WNVTRYEHSIGVMLLIKKLGGTIEEQIAGLLHDVSHTAFSHVVDVVFENQAEDYHENI FQQVIVHSEIPDILQKHGYHTEELLSDDSRWTLLEQPAPELCADRTDYTLRDMYRYGH INLHEAQTFLDHLIVRNGRMFPDSIEAAEWFVSVYYKEVIDFFLNPVNVYGYEYLARA LKAALRHDVISAEDLLKTDQEVLNILRASKNEEVLSLLTSIHPGIQVIEDDIQYDFHQ KKKMRLIDPSIFLDDKWIKSSGVSEKVRKMGEAAYQKAKKGVYIKILKQ*" /label="ydhJ CDS" gene 584431..585408 /gene="ydhJ" /locus_tag="BSU_05780" /old_locus_tag="BSU05780" /label="ydhJ gene" downshifts 585388 /Source="Nicolas_upshifts" /id="D280" /incds=0 /nref=2 /ntot=92 /MaxReadThrough="2.31799" /MaxDrop="3.19063" /score="28.8500849" /energy="-8.1" /TU="NA" /idTUdmin="U451" /TUdmin="-770" /isTUend="FALSE" /label="downshifts" promotor_-35 585435..585441 /Source="Nicolas_upshift_promotors" /id="U451" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=176 /SigmaFactorBS="agtaattgccgcctgacagcggctttttttaTGTTTGGcttt gcaaacaaagGGGAATAGGACAAACTGCGggaacgctttatgagaatatcagcgtatt t" /listShort="ydhK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 585456..585474 /Source="Nicolas_upshift_promotors" /id="U451" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=176 /SigmaFactorBS="agtaattgccgcctgacagcggctttttttaTGTTTGGcttt gcaaacaaagGGGAATAGGACAAACTGCGggaacgctttatgagaatatcagcgtatt t" /listShort="ydhK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 585464 /Source="Nicolas_upshifts" /id="U451" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=176 /SigmaFactorBS="agtaattgccgcctgacagcggctttttttaTGTTTGGcttt gcaaacaaagGGGAATAGGACAAACTGCGggaacgctttatgagaatatcagcgtatt t" /listShort="ydhK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 585500..585507 /Source="Nicolas_upshift_promotors" /id="U452" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.434565434565435" /psig="0.98001998001998" /xcortree=1765 /SigmaFactorBS="ataggacaaactgcgggaacgctttatgagaatatcagcgTA TTTACAtaccgttcgggggTATAGTATTATCGAGAGGGCatgttttcattgtctgcgg g" /listShort="ydhK" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 585520 /Source="Nicolas_upshifts" /id="U452" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.434565434565435" /psig="0.98001998001998" /xcortree=1765 /SigmaFactorBS="ataggacaaactgcgggaacgctttatgagaatatcagcgTA TTTACAtaccgttcgggggTATAGTATTATCGAGAGGGCatgttttcattgtctgcgg g" /listShort="ydhK" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 585521..585540 /Source="Nicolas_upshift_promotors" /id="U452" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.434565434565435" /psig="0.98001998001998" /xcortree=1765 /SigmaFactorBS="ataggacaaactgcgggaacgctttatgagaatatcagcgTA TTTACAtaccgttcgggggTATAGTATTATCGAGAGGGCatgttttcattgtctgcgg g" /listShort="ydhK" /GFF_Attribute="listLong" /label="promotor_-10" CDS 585550..586167 /gene="ydhK" /locus_tag="BSU_05790" /old_locus_tag="BSU05790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_388460.1" /db_xref="EnsemblGenomes-Gn:BSU05790" /db_xref="EnsemblGenomes-Tr:CAB12398" /db_xref="InterPro:IPR011438" /db_xref="PDB:2KY9" /db_xref="PDB:4FIB" /db_xref="PDB:4MDW" /db_xref="SubtiList:BG12188" /db_xref="UniProtKB/Swiss-Prot:O05503" /translation="MSAGKSYRKKMKQRRMNMKISKYALGILMLSLVFVLSACGNNNS TKESTHDNHSDSSTHEEMDHSGSADVPEGLQESKNPKYKVGSQVIINTSHMKGMKGAE ATVTGAYDTTAYVVSYTPTNGGQRVDHHKWVIQEEIKDAGDKTLQPGDQVILEASHMK GMKGATAEIDSAEKTTVYMVDYTSTTSGEKVKNHKWVTEDELSAK*" /label="ydhK CDS" gene 585550..586167 /gene="ydhK" /locus_tag="BSU_05790" /old_locus_tag="BSU05790" /label="ydhK gene" downshifts 586154 /Source="Nicolas_upshifts" /id="D281" /incds=0 /nref=62 /ntot=212 /MaxReadThrough="1.07295" /MaxDrop="7.27889" /score="30.3859931" /energy="-11.4" /TU="U452" /idTUdmin="U451" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS complement(586183..587349) /gene="pbuE" /locus_tag="BSU_05800" /old_locus_tag="BSU05800" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12923093, 15849754, 16850406, 17935948, 25573585" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12923093, 15849754, 16850406, 17935948, 25573585; Product type t : transporter" /codon_start=1 /transl_table=11 /product="hypoxanthine efflux transporter" /protein_id="NP_388461.2" /db_xref="EnsemblGenomes-Gn:BSU05800" /db_xref="EnsemblGenomes-Tr:CAB12399" /db_xref="GOA:Q797E3" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12189" /db_xref="UniProtKB/Swiss-Prot:Q797E3" /translation="MNFKVFLLAASTIAVGLVELIVGGILPQIANDLDISIVSAGQLI SVFALGYAVSGPLLLALTAKIERKRLYLIALFVFFLSNLVAYFSPNFATLMVSRVLAA MSTGLIVVLSLTIAPKIVAPEYRARAIGIIFMGFSSAIALGVPLGILISDSFGWRILF LGIGLLALISMLIISIFFERIPAEKMIPFREQLKTIGNLKIASSHLVTMFTLAGHYTL YAYFAPFLEETLHLSSFWVSICYFLFGISAVCGGPFGGALSDRLGSFKSILLVTGSFA IIMFLLPLSTSSMIFFLPVMVIWGLLSWSLAPAQQSYLIEIAPDSSDIQQSFNTSALQ VGIALGSAIGGVVLDQTGTVVSTAWCGGSIVIIAVLFAFISLTRPVQTAKKSSL*" /label="pbuE CDS" gene complement(586183..587349) /gene="pbuE" /locus_tag="BSU_05800" /old_locus_tag="BSU05800" /label="pbuE gene" downshifts complement(586212) /Source="Nicolas_upshifts" /id="D282" /incds=0 /nref=40 /ntot=58 /MaxReadThrough="2.22188" /MaxDrop="4.89202" /score="36.362851" /energy="-12.4" /TU="NA" /idTUdmin="U453" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_RNA complement(587404..587504) /gene="aswA" /locus_tag="BSU_misc_RNA_8" /product="adenine riboswitch" /experiment="publication(s) with functional evidences, PMID:14718920, 16201765, 19603494, 20022916, 21283784, 23087247, 25573585" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14718920, 16201765, 19603494, 20022916, 21283784, 23087247, 25573585; Product type n: RNA" /label="aswA RNA" gene complement(587404..587504) /gene="aswA" /locus_tag="BSU_misc_RNA_8" /label="aswA gene" downshifts complement(587445) /Source="Nicolas_upshifts" /id="D283" /incds=0 /nref=38 /ntot=127 /MaxReadThrough="5.85661" /MaxDrop="6.06248" /score="33.0784595" /energy="-19.4" /TU="U453" /idTUdmin="U453" /TUdmin="-1233" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(587514..587533) /Source="Nicolas_upshift_promotors" /id="U453" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.95104895104895" /psig=1 /xcortree=2453 /SigmaFactorBS="tatttttttccggttcaccgttttataaatttttcTATGGaa gattcattcataaTGTGGTACACTCATCAACGGaaacgaatcaattaaatagctatta t" /listShort="NA, pbuE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(587528) /Source="Nicolas_upshifts" /id="U453" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.95104895104895" /psig=1 /xcortree=2453 /SigmaFactorBS="tatttttttccggttcaccgttttataaatttttcTATGGaa gattcattcataaTGTGGTACACTCATCAACGGaaacgaatcaattaaatagctatta t" /listShort="NA, pbuE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(587549..587553) /Source="Nicolas_upshift_promotors" /id="U453" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.95104895104895" /psig=1 /xcortree=2453 /SigmaFactorBS="tatttttttccggttcaccgttttataaatttttcTATGGaa gattcattcataaTGTGGTACACTCATCAACGGaaacgaatcaattaaatagctatta t" /listShort="NA, pbuE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 587612..587619 /Source="Nicolas_upshift_promotors" /id="U454" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.85914085914086" /psig="0.999000999001" /xcortree=1575 /SigmaFactorBS="aaaaaaatatgattatatttattttataaaagTATAGACAtt taaaattaaatGACTATAATAATCAATGTAAgcgttttaataacaggggggatagcag t" /listShort="gmuB, gmuA, gmuC, gmuD, S203, gmuR, gmuE, gmuF, gmuG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 587633..587652 /Source="Nicolas_upshift_promotors" /id="U454" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.85914085914086" /psig="0.999000999001" /xcortree=1575 /SigmaFactorBS="aaaaaaatatgattatatttattttataaaagTATAGACAtt taaaattaaatGACTATAATAATCAATGTAAgcgttttaataacaggggggatagcag t" /listShort="gmuB, gmuA, gmuC, gmuD, S203, gmuR, gmuE, gmuF, gmuG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 587640 /Source="Nicolas_upshifts" /id="U454" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.85914085914086" /psig="0.999000999001" /xcortree=1575 /SigmaFactorBS="aaaaaaatatgattatatttattttataaaagTATAGACAtt taaaattaaatGACTATAATAATCAATGTAAgcgttttaataacaggggggatagcag t" /listShort="gmuB, gmuA, gmuC, gmuD, S203, gmuR, gmuE, gmuF, gmuG" /GFF_Attribute="listLong" /label="upshifts" CDS 587680..587991 /gene="gmuB" /locus_tag="BSU_05810" /old_locus_tag="BSU05810" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 18177310; Product type t : transporter" /codon_start=1 /transl_table=11 /product="oligo-alpha-mannoside phosphotransferase system enzyme IIB" /protein_id="NP_388462.1" /db_xref="EnsemblGenomes-Gn:BSU05810" /db_xref="EnsemblGenomes-Tr:CAB12400" /db_xref="GOA:O05505" /db_xref="InterPro:IPR003501" /db_xref="InterPro:IPR013012" /db_xref="InterPro:IPR036095" /db_xref="SubtiList:BG12190" /db_xref="UniProtKB/Swiss-Prot:O05505" /translation="MKKILLACSSGMSTSLLVTKMKEYAQSIGEEAEIWAVGQDKAKE DMRKADAVLIGPQMSFLKSELQKEADQYNIQVEVIDMMAYGMADGKKAYEQALSLMVN Q*" /label="gmuB CDS" gene 587680..587991 /gene="gmuB" /locus_tag="BSU_05810" /old_locus_tag="BSU05810" /label="gmuB gene" CDS 587991..588323 /gene="gmuA" /locus_tag="BSU_05820" /old_locus_tag="BSU05820" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type t: transporter" /codon_start=1 /transl_table=11 /product="oligo-alpha-mannoside phosphotransferase system enzyme IIA" /protein_id="NP_388463.2" /db_xref="EnsemblGenomes-Gn:BSU05820" /db_xref="EnsemblGenomes-Tr:CAB12401" /db_xref="GOA:O05506" /db_xref="InterPro:IPR003188" /db_xref="InterPro:IPR036542" /db_xref="SubtiList:BG12191" /db_xref="UniProtKB/Swiss-Prot:O05506" /translation="MEQMKITNLTDEQISFQLILHSGNARSCIIQSLRAYKEGKKDEA DALIAKAEQDLSAAHDIHFQMIQKESGGEATAFSLLLMHAEDHLMSTLSMKELVKEML DLFKTKNI*" /label="gmuA CDS" gene 587991..588323 /gene="gmuA" /locus_tag="BSU_05820" /old_locus_tag="BSU05820" /label="gmuA gene" CDS 588342..589670 /gene="gmuC" /locus_tag="BSU_05830" /old_locus_tag="BSU05830" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16850406, 18177310; Product type t: transporter" /codon_start=1 /transl_table=11 /product="oligo-alpha-mannoside phosphotransferase system enzyme IIC" /protein_id="NP_388464.1" /db_xref="EnsemblGenomes-Gn:BSU05830" /db_xref="EnsemblGenomes-Tr:CAB12402" /db_xref="GOA:O05507" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR004501" /db_xref="InterPro:IPR004796" /db_xref="SubtiList:BG12192" /db_xref="UniProtKB/Swiss-Prot:O05507" /translation="MFEKISQFLVPIAGRLNNNRYLQVLRDAFMLAFPLTIFGSIFVV LTNLPFLNKIMNASMLTSFQSHFGIASTATMGIMSVFVVFGIGYYLSKSYQVEAVFGG AIALVSFLLLTPFIIQPETGDAITGVIPVDRLGAKGMFLGMITAFLSGEIYRRIVQKN LTIKMPAGVPPAVAKSFAALIPAFITLTVFLLINVMVTLFFKTNMHDVIYHAIQAPLV GLGSGIIPTLIAVFFIQILWFFGLHGQIIINSVMDPIWNTLQVENLSAYTAGKEIPHI ISKPFMEIYTVGMGGTGMTLAIVFTILIFMKSRQMKQVSKLGLAPGIFNVNEPIIFGL PIVMNPIIIVPWVLAPMVVTLVTYLAMSAGLVPPPTGVTVPWTVPLFINGIMATNSIM GGVMQLINLLIVFVIWFPFLKAMDKLNLAKEKEQAVQETAAQQNDNSIKM*" /label="gmuC CDS" gene 588342..589670 /gene="gmuC" /locus_tag="BSU_05830" /old_locus_tag="BSU05830" /label="gmuC gene" CDS 589688..591085 /gene="gmuD" /locus_tag="BSU_05840" /old_locus_tag="BSU05840" /EC_number="3.2.1.86" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14652714, 15139916, 18177310" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14652714, 15139916, 18177310; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="mannoside-phospho-beta-d-glucosidase" /protein_id="NP_388465.1" /db_xref="EnsemblGenomes-Gn:BSU05840" /db_xref="EnsemblGenomes-Tr:CAB12403" /db_xref="GOA:O05508" /db_xref="InterPro:IPR001360" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR018120" /db_xref="SubtiList:BG12193" /db_xref="UniProtKB/Swiss-Prot:O05508" /translation="MAHTEQYRFPKDFWWGSSASATQMEGAADRDGKGQNIWDYWFEK EPHRFFDHVGPADTSQFYDNYKEDIRLMKELGHNSFRMSISWSRLIPNGTGEINDKAA DFYNNVIDELIANGIEPFVNLFHFDMPMALQKIGGWVNRETVDAYENYARTCFRLFGG RVKKWFTHNEPIVPVEGGYLYDFHYPNKVDFKEAVQVGFHTMLSSARAIQAYREMKQD GKIGIILNLTPSYPRSSHPADVKAGEIADAFFNRSFLDPSVKGEFPKELVDILKHEGF MPDYNAEDLDIIKKNTVDLLGVNYYQPRRVKAKEHLPNPDAPFLPDRYFDPYVMPGRK MNPHRGWEIYEKGVYDILINLKENYGNIECFISENGMGVEGEERFRDEQGIIQDDYRI EFIKEHLKWIHRAIQEGSNVKGYHLWTFMDNWSWTNAYKNRYGFVSVNLEKDGERTVK KSGKWFKEVAEHSGF*" /label="gmuD CDS" gene 589688..591085 /gene="gmuD" /locus_tag="BSU_05840" /old_locus_tag="BSU05840" /label="gmuD gene" S_feature 591086..591172 /Source="Nicolas_S_feature" /locus_tag="new_630028_630114" /HighExp="G150, T0.30H, T1.0H, M40t90, T1.30H, Mt0, M0t90, Lbexp, dia0, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S203" promotor_-35 591150..591157 /Source="Nicolas_upshift_promotors" /id="U455" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74025974025974" /psig="0.997002997002997" /xcortree=640 /SigmaFactorBS="aatcatcataacgaatagagatgacgaaaatccgcaACATTG ATgaaatagggaaaaGAACTTATGATATCCGTAAAagcttatgtgatatcaaacagct g" /listShort="gmuR, gmuE, gmuF, gmuG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 591171..591190 /Source="Nicolas_upshift_promotors" /id="U455" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74025974025974" /psig="0.997002997002997" /xcortree=640 /SigmaFactorBS="aatcatcataacgaatagagatgacgaaaatccgcaACATTG ATgaaatagggaaaaGAACTTATGATATCCGTAAAagcttatgtgatatcaaacagct g" /listShort="gmuR, gmuE, gmuF, gmuG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 591174 /Source="Nicolas_upshifts" /id="U455" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74025974025974" /psig="0.997002997002997" /xcortree=640 /SigmaFactorBS="aatcatcataacgaatagagatgacgaaaatccgcaACATTG ATgaaatagggaaaaGAACTTATGATATCCGTAAAagcttatgtgatatcaaacagct g" /listShort="gmuR, gmuE, gmuF, gmuG" /GFF_Attribute="listLong" /label="upshifts" CDS 591228..591941 /gene="gmuR" /locus_tag="BSU_05850" /old_locus_tag="BSU05850" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:18177310" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18177310; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (GntR family)" /protein_id="NP_388466.1" /db_xref="EnsemblGenomes-Gn:BSU05850" /db_xref="EnsemblGenomes-Tr:CAB12404" /db_xref="GOA:O05509" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR011663" /db_xref="InterPro:IPR028978" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12194" /db_xref="UniProtKB/Swiss-Prot:O05509" /translation="MNKYEIIANEMRNRIKNNVYPIDQPIPDEVSLAKEFNSSRMTMK RALDNLVAEGLLFRKRGHGTFIIQSAIQDDHVHVVSNEILGLTNLLKDKKIKSKVIQF EVQFPTEEVAAHLSIDQKTPVYYVVRLRIVEGEPYVLEKTYMPTHLIPGINDDVLHDS IYNHITNVLQLKIAGTHRKIRACKSDHIDQQHLGCKQDDPILEVEHVGFLDTGIPFEY SFSRHRHDKFVVTSVNIRR*" /label="gmuR CDS" gene 591228..591941 /gene="gmuR" /locus_tag="BSU_05850" /old_locus_tag="BSU05850" /label="gmuR gene" CDS 591970..592869 /gene="gmuE" /locus_tag="BSU_05860" /old_locus_tag="BSU05860" /EC_number="2.7.1.4" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15018644, 18177310, 21185308" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15018644, 18177310, 21185308; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ROK fructokinase; glucomannan utilization protein E" /protein_id="NP_388467.1" /db_xref="EnsemblGenomes-Gn:BSU05860" /db_xref="EnsemblGenomes-Tr:CAB12405" /db_xref="GOA:O05510" /db_xref="InterPro:IPR000600" /db_xref="PDB:1XC3" /db_xref="PDB:3LM9" /db_xref="PDB:3OHR" /db_xref="SubtiList:BG12195" /db_xref="UniProtKB/Swiss-Prot:O05510" /translation="MLGGIEAGGTKFVCAVGREDGTIIDRIEFPTKMPDETIEKVIQY FSQFSLQAIGIGSFGPVDNDKTSQTYGTITATPKAGWRHYPFLQTVKNEMKIPVGFST DVNAAALGEFLFGEAKGLDSCLYITIGTGIGAGAIVEGRLLQGLSHPEMGHIYIRRHP DDVYQGKCPYHGDCFEGLASGPAIEARWGKKAADLSDIAQVWELEGYYIAQALAQYIL ILAPKKIILGGGVMQQKQVFSYIYQYVPKIMNSYLDFSELSDDISDYIVPPRLGSNAG IIGTLVLAHQALQAEAASGEVRS*" /label="gmuE CDS" gene 591970..592869 /gene="gmuE" /locus_tag="BSU_05860" /old_locus_tag="BSU05860" /label="gmuE gene" CDS 592866..593813 /gene="gmuF" /locus_tag="BSU_05870" /old_locus_tag="BSU05870" /EC_number="5.3.1.8" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 10704478, 18177310, 3017192; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphohexomutase; cupin family" /protein_id="NP_388468.1" /db_xref="EnsemblGenomes-Gn:BSU05870" /db_xref="EnsemblGenomes-Tr:CAB12406" /db_xref="GOA:O05511" /db_xref="InterPro:IPR001250" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014628" /db_xref="InterPro:IPR014710" /db_xref="SubtiList:BG12196" /db_xref="UniProtKB/Swiss-Prot:O05511" /translation="MTHPLFLEPVFKERLWGGTKLRDAFGYAIPSQKTGECWAVSAHA HGSSSVKNGPLAGKTLDQVWKDHPEIFGFPDGKVFPLLVKLLDANMDLSVQVHPDDDY AKLHENGDLGKTECWYIIDCKDDAELILGHHASTKEEFKQRIESGDWNGLLRRIKIKP GDFFYVPSGTLHALCKGTLVLEIQQNSDTTYRVYDYDRCNDQGQKRTLHIEKAMEVIT IPHIDKVHTPEVKEVGNAEIIVYVQSDYFSVYKWKISGRAAFPSYQTYLLGSVLSGSG RIINNGIQYECNAGSHFILPAHFGEFTIEGTCEFMISHP*" /label="gmuF CDS" gene 592866..593813 /gene="gmuF" /locus_tag="BSU_05870" /old_locus_tag="BSU05870" /label="gmuF gene" CDS 593832..594920 /gene="gmuG" /locus_tag="BSU_05880" /old_locus_tag="BSU05880" /EC_number="3.2.1.78" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:2694961, 7727534, 18177310, 28101462, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2694961, 7727534, 18177310, 28101462, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exported mannan endo-1,4-beta-mannosidase" /protein_id="NP_388469.2" /db_xref="EnsemblGenomes-Gn:BSU05880" /db_xref="EnsemblGenomes-Tr:CAB12407" /db_xref="GOA:O05512" /db_xref="InterPro:IPR000805" /db_xref="InterPro:IPR016714" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR022790" /db_xref="PDB:2WHK" /db_xref="PDB:3CBW" /db_xref="SubtiList:BG12197" /db_xref="UniProtKB/Swiss-Prot:O05512" /translation="MFKKHTISLLIIFLLASAVLAKPIEAHTVSPVNPNAQQTTKTVM NWLAHLPNRTENRVLSGAFGGYSHDTFSMAEADRIRSATGQSPAIYGCDYARGWLETA NIEDSIDVSCNGDLMSYWKNGGIPQISLHLANPAFQSGHFKTPITNDQYKKILDSSTV EGKRLNAMLSKIADGLQELENQGVPVLFRPLHEMNGEWFWWGLTSYNQKDNERISLYK QLYKKIYHYMTDTRGLDHLIWVYSPDANRDFKTDFYPGASYVDIVGLDAYFQDAYSIN GYDQLTALNKPFAFTEVGPQTANGSFDYSLFINAIKQKYPKTIYFLAWNDEWSAAVNK GASALYHDSWTLNKGEIWNGDSLTPIVE*" /label="gmuG CDS" gene 593832..594920 /gene="gmuG" /locus_tag="BSU_05880" /old_locus_tag="BSU05880" /label="gmuG gene" downshifts 594914 /Source="Nicolas_upshifts" /id="D284" /incds=0 /nref=1 /ntot=17 /MaxReadThrough="1.56881" /MaxDrop="2.87204" /score="7.63230089" /energy="-5.4" /TU="NA" /idTUdmin="U454" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(594981..595709) /gene="ydhUc" /locus_tag="BSU_05890" /old_locus_tag="BSU05890" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; Product type e : enzyme" /pseudo /codon_start=1 /transl_table=11 /product="Mn catalase fragment; C-terminal part of YhdU" /db_xref="SubtiList:BG12198" /translation="FFQSSNFRGKQKQYRDLLRGIFLEEIAHVELVQNTINALLDESG GEGVGSQGTDQAPLDEAVKHANPHHYIIGAQSSLPVDAGGNPWNGSWVYNHGNLITDL LDNLLLESTGVLQKTRIYEMSSNQTFRETLAFLIVRDNAHQNAFAKALETLGVEWAKL LPVPNYDINKYPECRKYVELGYHNTHFNFRLDETRISEIYQGKSPSRNGGELQVIDPP AGFPVPVLPEIPNEHSPGLGDMNA*" /label="ydhUc CDS" gene complement(594981..595709) /gene="ydhUc" /locus_tag="BSU_05890" /old_locus_tag="BSU05890" /pseudo /label="ydhUc gene" downshifts complement(595031) /Source="Nicolas_upshifts" /id="D285" /incds=0 /nref=13 /ntot=37 /MaxReadThrough="1.1517" /MaxDrop="5.0503" /score="0.317473754" /energy="-17.6" /TU="NA" /idTUdmin="U456" /TUdmin=3 /isTUend="TRUE" /label="downshifts" CDS complement(595640..595834) /gene="ydhUn" /locus_tag="BSU_05899" /old_locus_tag="BSU05899" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; Product type e : enzyme" /pseudo /codon_start=1 /transl_table=11 /product="Mn catalase fragment; N-terminal part of YhdU" /translation="MYYYKEELINIIKPDKPDPAAAKVLQEILGGHYGEMRTMMQFFS KALISEESRNSTAICFAAFF*" /label="ydhUn CDS" gene complement(595640..595834) /gene="ydhUn" /locus_tag="BSU_05899" /old_locus_tag="BSU05899" /pseudo /label="ydhUn gene" promotor_-10 complement(595867..595878) /Source="Nicolas_upshift_promotors" /id="U456" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=907 /SigmaFactorBS="ttattttcttctttcacgccttcccatgcttatcatgTATAT ATtttatctcatcttACAAATAATATAagaaaatctcttaagaagaaatgaggcgtgt t" /listShort="ydhU, ydhU" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(595875) /Source="Nicolas_upshifts" /id="U456" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=907 /SigmaFactorBS="ttattttcttctttcacgccttcccatgcttatcatgTATAT ATtttatctcatcttACAAATAATATAagaaaatctcttaagaagaaatgaggcgtgt t" /listShort="ydhU, ydhU" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(595892..595898) /Source="Nicolas_upshift_promotors" /id="U456" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=907 /SigmaFactorBS="ttattttcttctttcacgccttcccatgcttatcatgTATAT ATtttatctcatcttACAAATAATATAagaaaatctcttaagaagaaatgaggcgtgt t" /listShort="ydhU, ydhU" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 595953..595960 /Source="Nicolas_upshift_promotors" /id="U457" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2625 /SigmaFactorBS="cgtgaaagaagaaaataaaaaaatacaggaaaagtGTTGACC AaataaaacaggcaTGGTATATTATTAAACGTCGctgatgaacagcgtgaaacaaaac a" /listShort="S204, trnE-Arg, trnE-Gly, rrnE-16S" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 595974..595993 /Source="Nicolas_upshift_promotors" /id="U457" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2625 /SigmaFactorBS="cgtgaaagaagaaaataaaaaaatacaggaaaagtGTTGACC AaataaaacaggcaTGGTATATTATTAAACGTCGctgatgaacagcgtgaaacaaaac a" /listShort="S204, trnE-Arg, trnE-Gly, rrnE-16S" /GFF_Attribute="listLong" /label="promotor_-10" promotor_no_box 595976..596076 /Source="Nicolas_upshift_promotors" /id="U458" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.604395604395604" /psig="0.0919080919080919" /xcortree=1636 /SigmaFactorBS="gtatattattaaacgtcgctgatgaacagcgtgaaacaaaac agaaaaacaaaaaagttttcctaaggtgtttacaagattttaaaaatgtgtataataa g" /listShort="S204, trnE-Arg, trnE-Gly, rrnE-16S" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 595978 /Source="Nicolas_upshifts" /id="U457" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2625 /SigmaFactorBS="cgtgaaagaagaaaataaaaaaatacaggaaaagtGTTGACC AaataaaacaggcaTGGTATATTATTAAACGTCGctgatgaacagcgtgaaacaaaac a" /listShort="S204, trnE-Arg, trnE-Gly, rrnE-16S" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(596024) /Source="Nicolas_upshifts" /id="D286" /incds=0 /nref=1 /ntot=54 /MaxReadThrough="2.24619" /MaxDrop="4.20389" /score="11.9939391" /energy="-9" /TU="NA" /idTUdmin="U456" /TUdmin="-990" /isTUend="FALSE" /label="downshifts" upshifts 596036 /Source="Nicolas_upshifts" /id="U458" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.604395604395604" /psig="0.0919080919080919" /xcortree=1636 /SigmaFactorBS="gtatattattaaacgtcgctgatgaacagcgtgaaacaaaac agaaaaacaaaaaagttttcctaaggtgtttacaagattttaaaaatgtgtataataa g" /listShort="S204, trnE-Arg, trnE-Gly, rrnE-16S" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 596044..596051 /Source="Nicolas_upshift_promotors" /id="U459" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.418581418581419" /psig="0.96003996003996" /xcortree=1634 /SigmaFactorBS="aaaaacaaaaaagttttcctaaggTGTTTACAagattttaaa aatGTGTATAATAAGAAAAGTCGaattgaaaaagattcgaaaaaacattaaaaaactt c" /listShort="S204, trnE-Arg, trnE-Gly, rrnE-16S" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 596065..596084 /Source="Nicolas_upshift_promotors" /id="U459" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.418581418581419" /psig="0.96003996003996" /xcortree=1634 /SigmaFactorBS="aaaaacaaaaaagttttcctaaggTGTTTACAagattttaaa aatGTGTATAATAAGAAAAGTCGaattgaaaaagattcgaaaaaacattaaaaaactt c" /listShort="S204, trnE-Arg, trnE-Gly, rrnE-16S" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 596080..596167 /Source="Nicolas_S_feature" /locus_tag="new_635022_635109" /HighExp="LBGstat, C30, Cold, Heat, Oxctl, T-1.10H, T-0.40H, T-1.40H, UNK1, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-, SigA" /TUshortPSig="0.96, 0.0919, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S204" upshifts 596080 /Source="Nicolas_upshifts" /id="U459" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.418581418581419" /psig="0.96003996003996" /xcortree=1634 /SigmaFactorBS="aaaaacaaaaaagttttcctaaggTGTTTACAagattttaaa aatGTGTATAATAAGAAAAGTCGaattgaaaaagattcgaaaaaacattaaaaaactt c" /listShort="S204, trnE-Arg, trnE-Gly, rrnE-16S" /GFF_Attribute="listLong" /label="upshifts" tRNA 596168..596244 /gene="trnE-Arg" /locus_tag="BSU_tRNA_79" /product="tRNA-Arg" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnE-Arg tRNA" gene 596168..596244 /gene="trnE-Arg" /locus_tag="BSU_tRNA_79" /label="trnE-Arg gene" tRNA 596258..596331 /gene="trnE-Gly" /locus_tag="BSU_tRNA_80" /product="tRNA-Gly" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Gly(UCC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnE-Gly tRNA" gene 596258..596331 /gene="trnE-Gly" /locus_tag="BSU_tRNA_80" /label="trnE-Gly gene" rRNA 596491..598045 /gene="rrnE-16S" /locus_tag="BSU_rRNA_30" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnE-16S rRNA" gene 596491..598045 /gene="rrnE-16S" /locus_tag="BSU_rRNA_30" /label="rrnE-16S gene" rRNA 598213..601140 /gene="rrnE-23S" /locus_tag="BSU_rRNA_12" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnE-23S rRNA" gene 598213..601140 /gene="rrnE-23S" /locus_tag="BSU_rRNA_12" /label="rrnE-23S gene" rRNA 601196..601312 /gene="rrnE-5S" /locus_tag="BSU_rRNA_13" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnE-5S rRNA" gene 601196..601312 /gene="rrnE-5S" /locus_tag="BSU_rRNA_13" /label="rrnE-5S gene" tRNA 601326..601402 /gene="trnE-Met" /locus_tag="BSU_tRNA_21" /product="tRNA-Met" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Met(CAU); Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnE-Met tRNA" gene 601326..601402 /gene="trnE-Met" /locus_tag="BSU_tRNA_21" /label="trnE-Met gene" tRNA 601463..601539 /gene="trnE-Asp" /locus_tag="BSU_tRNA_22" /product="tRNA-Asp" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Asp(GUC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnE-Asp tRNA" gene 601463..601539 /gene="trnE-Asp" /locus_tag="BSU_tRNA_22" /label="trnE-Asp gene" downshifts 601536 /Source="Nicolas_upshifts" /id="D287" /incds=0 /nref=38 /ntot=211 /MaxReadThrough="6.00554" /MaxDrop="5.14761" /score="7.63230089" /energy="-5.4" /TU="NA" /idTUdmin="U460" /TUdmin="-3784" /isTUend="FALSE" /label="downshifts" promotor_-35 601640..601644 /Source="Nicolas_upshift_promotors" /id="U460" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.942057942057942" /psig=1 /xcortree=2461 /SigmaFactorBS="tggtgtcatagccaagctttctttatatcgggaacaTCTTGg atattccagcaaaaTTCGATAAACTAGGAAGAGCacaaataggcataagcagggttga a" /listShort="thiL, ydiB, ydiC, rimI, gcp" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 601660..601679 /Source="Nicolas_upshift_promotors" /id="U460" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.942057942057942" /psig=1 /xcortree=2461 /SigmaFactorBS="tggtgtcatagccaagctttctttatatcgggaacaTCTTGg atattccagcaaaaTTCGATAAACTAGGAAGAGCacaaataggcataagcagggttga a" /listShort="thiL, ydiB, ydiC, rimI, gcp" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 601664 /Source="Nicolas_upshifts" /id="U460" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.942057942057942" /psig=1 /xcortree=2461 /SigmaFactorBS="tggtgtcatagccaagctttctttatatcgggaacaTCTTGg atattccagcaaaaTTCGATAAACTAGGAAGAGCacaaataggcataagcagggttga a" /listShort="thiL, ydiB, ydiC, rimI, gcp" /GFF_Attribute="listLong" /label="upshifts" CDS 601720..602697 /gene="thiL" /locus_tag="BSU_05900" /old_locus_tag="BSU05900" /EC_number="2.7.4.16" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16291685, 26443755; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thiamine-monophosphate kinase" /protein_id="NP_388471.1" /db_xref="EnsemblGenomes-Gn:BSU05900" /db_xref="EnsemblGenomes-Tr:CAB12409" /db_xref="GOA:O05514" /db_xref="InterPro:IPR006283" /db_xref="InterPro:IPR010918" /db_xref="InterPro:IPR016188" /db_xref="InterPro:IPR036676" /db_xref="InterPro:IPR036921" /db_xref="SubtiList:BG10693" /db_xref="UniProtKB/Swiss-Prot:O05514" /translation="MDEFDLIHSITPRTIHHSSVDVGIGDDAALYTAKHGVQEIVCVD TMVEDVHFKLHYSSPEDIGYKALAVNISDIAAMGGIPKFYLVSLAVPSKWTESEIKAM YEGMNELAKLYHMDLIGGDTVSTADKLVVTVTVIGEIEKGQACLRSLAKPNDIVFVTG EIGSSAAGLSLLLEETNPQNSSVETDYFIHRHKRPEPRVSVGRLCSIFKRAALNDVSD GLASELNEIAEASCVSIEIVESMLPIHSDLPKLHPNWKEWALFGGEDFELTGTVSNEE WEVLKQECAALHLPITKIGYVREKTKSKVILKTDQTSMILEKKGYNHFK*" /label="thiL CDS" gene 601720..602697 /gene="thiL" /locus_tag="BSU_05900" /old_locus_tag="BSU05900" /label="thiL gene" CDS 602712..603188 /gene="tsaE" /locus_tag="BSU_05910" /old_locus_tag="BSU05910" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 17005971, 19246765, 19376873, 19578062, 20701780, 20824107, 21183954, 21285948, 22378793, 23072323" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17005971, 19246765, 19376873, 19578062, 20701780, 20824107, 21183954, 21285948, 22378793, 23072323; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="tRNA(NNU) t(6)A37 threonylcarbamoyladenosine modification; ADP binding protein" /protein_id="NP_388472.1" /db_xref="EnsemblGenomes-Gn:BSU05910" /db_xref="EnsemblGenomes-Tr:CAB12410" /db_xref="GOA:O05515" /db_xref="InterPro:IPR003442" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12199" /db_xref="UniProtKB/Swiss-Prot:O05515" /translation="MKQLKWRTVNPEETKAIAKLTAAFAKPGDVLTLEGDLGAGKTTF TKGFAEGLGITRIVNSPTFTIIKEYNDGVLPLYHMDVYRMEDESEDLGLDEYFHGQGV CLVEWAHLIEEQLPQERLQIVIKRAGDDEREITFTAVGNRYEMLCEELSRHDNISN*" /label="tsaE CDS" gene 602712..603188 /gene="tsaE" /locus_tag="BSU_05910" /old_locus_tag="BSU05910" /label="tsaE gene" CDS 603169..603858 /gene="tsaB" /locus_tag="BSU_05920" /old_locus_tag="BSU05920" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12682299, 17005971, 20944216, 19376873, 19578062, 20701780, 20824107, 21183954, 21285948, 22378793, 23072323" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17005971, 20944216, 19376873, 19578062, 20701780, 20824107, 21183954, 21285948, 22378793, 23072323; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="tRNA(NNU) t(6)A37 threonylcarbamoyladenosine modification; protease involved in TsaD function" /protein_id="NP_388473.1" /db_xref="EnsemblGenomes-Gn:BSU05920" /db_xref="EnsemblGenomes-Tr:CAB12411" /db_xref="GOA:O05516" /db_xref="InterPro:IPR000905" /db_xref="InterPro:IPR022496" /db_xref="SubtiList:BG12200" /db_xref="UniProtKB/Swiss-Prot:O05516" /translation="MTILAIDTSNYTLGIALLREDTVIAEYITYLKKNHSVRAMPAVH SLLNDCDMAPQDLSKIVVAKGPGSYTGVRIGVTLAKTLAWSLDIPISAVSSLETLAAN GRHFDGLISPIFDARRGQVYTGLYQYKNGLLEQVVPDQNVMLADWLEMLKEKDRPVLF LGHDTSLHKQMIEDVLGTKGFIGTAAQHNPRPSELAFLGKEKEAADVHGLVPDYLRLA EAEAKWIESQK*" /label="tsaB CDS" gene 603169..603858 /gene="tsaB" /locus_tag="BSU_05920" /old_locus_tag="BSU05920" /label="tsaB gene" CDS 603868..604323 /gene="rimI" /locus_tag="BSU_05930" /old_locus_tag="BSU05930" /EC_number="2.3.1.267" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2828880; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ribosomal protein S18 alanine N-acetyltransferase" /protein_id="NP_388474.1" /db_xref="EnsemblGenomes-Gn:BSU05930" /db_xref="EnsemblGenomes-Tr:CAB12412" /db_xref="GOA:O05517" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR006464" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG12201" /db_xref="UniProtKB/Swiss-Prot:O05517" /translation="MKTKAAVRNMRLEDIDHVYEIEASSFTSPWTKDSFYHELLENPY AHYLVIEKDGHLAGYCGIWIVMDDAQITNIAIKPEYRGQSLGETLFRSAVELCKEKDA RRLSLEVRVSNHPAQGLYKKFGMQPGGIRKNYYTDNGEDALIMWVTINE*" /label="rimI CDS" gene 603868..604323 /gene="rimI" /locus_tag="BSU_05930" /old_locus_tag="BSU05930" /label="rimI gene" CDS 604316..605356 /gene="tsaD" /locus_tag="BSU_05940" /old_locus_tag="BSU05940" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11073929, 12682299, 9743119, 20824107, 21625506, 21873492, 19376873, 19578062, 20701780, 20824107, 21183954, 21285948, 22378793; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA(NNU) t(6)A37 threonylcarbamoyladenosine modification; glycation binding protein" /protein_id="NP_388475.1" /db_xref="EnsemblGenomes-Gn:BSU05940" /db_xref="EnsemblGenomes-Tr:CAB12413" /db_xref="GOA:O05518" /db_xref="InterPro:IPR000905" /db_xref="InterPro:IPR017860" /db_xref="InterPro:IPR017861" /db_xref="InterPro:IPR022450" /db_xref="SubtiList:BG12202" /db_xref="UniProtKB/Swiss-Prot:O05518" /translation="MSEQKDMYVLGIETSCDETAAAIVKNGKEIISNVVASQIESHKR FGGVVPEIASRHHVEQITLVIEEAFRKAGMTYSDIDAIAVTEGPGLVGALLIGVNAAK ALSFAYNIPLVGVHHIAGHIYANRLVEDIVFPALALVVSGGHTELVYMKEHGSFEVIG ETLDDAAGEAYDKVARTMGLPYPGGPQIDKLAEKGNDNIPLPRAWLEEGSYNFSFSGL KSAVINTLHNASQKGQEIAPEDLSASFQNSVIDVLVTKTARAAKEYDVKQVLLAGGVA ANRGLRAALEKEFAQHEGITLVIPPLALCTDNAAMIAAAGTIAFEKGIRGAYDMNGQP GLELTSYQSLTR*" /label="tsaD CDS" gene 604316..605356 /gene="tsaD" /locus_tag="BSU_05940" /old_locus_tag="BSU05940" /label="tsaD gene" downshifts 605320 /Source="Nicolas_upshifts" /id="D288" /incds=0 /nref=39 /ntot=222 /MaxReadThrough="3.15518" /MaxDrop="4.65228" /score="3.97936019" /energy="-10.1" /TU="NA" /idTUdmin="U460" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(605586..607514) /gene="ydiF" /locus_tag="BSU_05950" /old_locus_tag="BSU05950" /function="16.8: Protect" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11916677, 16109936, 24389466; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative energy-sensing inhibitor of translation" /protein_id="NP_388476.2" /db_xref="EnsemblGenomes-Gn:BSU05950" /db_xref="EnsemblGenomes-Tr:CAB12414" /db_xref="GOA:O05519" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR032524" /db_xref="InterPro:IPR032781" /db_xref="SubtiList:BG12203" /db_xref="UniProtKB/Swiss-Prot:O05519" /translation="MMILQVNQLSKSFGADTILNNIKLEVRNRDRIAIVGRNGAGKST LLKIIAGQLSYEKGEIIKPKDITMGYLAQHTGLDSKLTIKEELLTVFDHLKAMEKEMR AMEEKMAAADPGELESIMKTYDRLQQEFKDKGGYQYEADVRSVLHGLGFSHFDDSTQV QSLSGGQKTRLALGKLLLTQPDLLILDEPTNHLDIDTLTWLEHYLQGYSGAILIVSHD RYFLDKVVNQVYEVSRAESKKYHGNYSAYLDQKAAQYEKDLKMYEKQQDEIAKLQDFV DRNLARASTTKRAQSRRKQLERMDVMSKPLGDEKSANFHFDITKQSGNEVLRVQDLTI SYENQPPLLTEVSFMLTRGESAALVGPNGIGKSTLLKTLIDTLKPDQGTISYGSNVSV GYYDQEQAELTSSKRVLDELWDEYPGLPEKEIRTCLGNFLFSGDDVLKPVHSLSGGEK ARLALAKLMLQKANFLILDEPTNHLDLDSKEVLENALIDYPGTLLFVSHDRYFINRIA TRVLELSSSHIEEYLGDYDYYTEKKTEQLELEKMNQQEETDKTPATVKSDSKRSYEEE KEWKKKERQRLRRIEEIETTVQTIEENISRNDELLCDPEVYQDHEKVQAIHADNEKLN QELESLLSEWEELSTEED*" /label="ydiF CDS" gene complement(605586..607514) /gene="ydiF" /locus_tag="BSU_05950" /old_locus_tag="BSU05950" /label="ydiF gene" downshifts complement(605603) /Source="Nicolas_upshifts" /id="D289" /incds=0 /nref=170 /ntot=266 /MaxReadThrough="1.32926" /MaxDrop="5.81869" /score="16.702581" /energy="-12.6" /TU="NA" /idTUdmin="U463" /TUdmin="-9" /isTUend="TRUE" /label="downshifts" misc_feature 607266..607285 /Source="Nicolas_upshift_promotors" /id="U461" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.821178821178821" /psig="0.98901098901099" /xcortree=2080 /SigmaFactorBS="tccttttccattgcttttaagtggtcaaaaacagtcagcagc tcttctttTATGGTAAGCTTAGAATCCAagccagtatgctgggcgagatatcccattg t" /listShort="S205, S206, moaC, rex, tatAY, tatCY" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 607276 /Source="Nicolas_upshifts" /id="U461" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.821178821178821" /psig="0.98901098901099" /xcortree=2080 /SigmaFactorBS="tccttttccattgcttttaagtggtcaaaaacagtcagcagc tcttctttTATGGTAAGCTTAGAATCCAagccagtatgctgggcgagatatcccattg t" /listShort="S205, S206, moaC, rex, tatAY, tatCY" /GFF_Attribute="listLong" /label="upshifts" S_feature 607278..607467 /Source="Nicolas_S_feature" /locus_tag="new_646220_646409" /HighExp="Diami, H2O2, dia5, Paraq, G135, G180, G150, Cold, dia15, BC" /AntisenseName="ydiF" /AntisenseCor="0.47406689574609401" /AntisenseRegPval="-15.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.989" /TUlongSig="NA" /TUlongPSig="NA" /label="S205" promotor_-35 607432..607439 /Source="Nicolas_upshift_promotors" /id="U462" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig="0.997002997002997" /xcortree=2055 /SigmaFactorBS="ctacaatggcgatgcgatcacgaTTTCTGACttccagcttta taTTGTTTAAAATAGTATCAGCaccaaatgatttggacagctgattaacttgtaagat c" /listShort="S206, moaC, rex, tatAY, tatCY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 607453..607472 /Source="Nicolas_upshift_promotors" /id="U462" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig="0.997002997002997" /xcortree=2055 /SigmaFactorBS="ctacaatggcgatgcgatcacgaTTTCTGACttccagcttta taTTGTTTAAAATAGTATCAGCaccaaatgatttggacagctgattaacttgtaagat c" /listShort="S206, moaC, rex, tatAY, tatCY" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 607469..607639 /Source="Nicolas_S_feature" /locus_tag="new_646411_646581" /HighExp="Diami, dia5, dia15, H2O2, Etha, G180, G150, Oxctl, Mt0, Paraq" /AntisenseName="ydiF" /AntisenseCor="0.63697451027099605" /AntisenseRegPval="-31.3" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 0.989" /TUlongSig="NA" /TUlongPSig="NA" /label="S206" upshifts 607469 /Source="Nicolas_upshifts" /id="U462" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig="0.997002997002997" /xcortree=2055 /SigmaFactorBS="ctacaatggcgatgcgatcacgaTTTCTGACttccagcttta taTTGTTTAAAATAGTATCAGCaccaaatgatttggacagctgattaacttgtaagat c" /listShort="S206, moaC, rex, tatAY, tatCY" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(607534..607553) /Source="Nicolas_upshift_promotors" /id="U463" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=2085 /SigmaFactorBS="tttcttctctatgtcttatatggccaatgtatTGTTTGCTga cttctggttcaTAAGCTACACTTAACTTATTatagcagaggtgaaataatatgatgat c" /listShort="ydiF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(607546) /Source="Nicolas_upshifts" /id="U463" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=2085 /SigmaFactorBS="tttcttctctatgtcttatatggccaatgtatTGTTTGCTga cttctggttcaTAAGCTACACTTAACTTATTatagcagaggtgaaataatatgatgat c" /listShort="ydiF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(607567..607574) /Source="Nicolas_upshift_promotors" /id="U463" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=2085 /SigmaFactorBS="tttcttctctatgtcttatatggccaatgtatTGTTTGCTga cttctggttcaTAAGCTACACTTAACTTATTatagcagaggtgaaataatatgatgat c" /listShort="ydiF" /GFF_Attribute="listLong" /label="promotor_-35" CDS 607640..608152 /gene="moaC" /locus_tag="BSU_05960" /old_locus_tag="BSU05960" /EC_number="4.6.1.17" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10903949, 16632608, 18607082, 20606263, 25941396, 26575208; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="molybdenum cofactor biosynthesis protein C" /protein_id="NP_388477.1" /db_xref="EnsemblGenomes-Gn:BSU05960" /db_xref="EnsemblGenomes-Tr:CAB12415" /db_xref="GOA:O05520" /db_xref="InterPro:IPR002820" /db_xref="InterPro:IPR023045" /db_xref="InterPro:IPR036522" /db_xref="SubtiList:BG12204" /db_xref="UniProtKB/Swiss-Prot:O05520" /translation="MNGFSHFNEQGRAQMVDISEKSSTVRTAAAVSSVHMKNEVYEKI QSHDIGKGDVLAVAQVAGIMAAKQTSNIIPMCHPLSLSGVDISFDWKIKEAEVILHIK AQVKTKGSTGVEMEALTSASVCALTVYDMCKALDKGMVIGPTFLLEKTGGKNGDFKRE LSEYNLEDQK*" /label="moaC CDS" gene 607640..608152 /gene="moaC" /locus_tag="BSU_05960" /old_locus_tag="BSU05960" /label="moaC gene" CDS 608149..608796 /gene="rex" /locus_tag="BSU_05970" /old_locus_tag="BSU05970" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15231791, 16207915, 17015645, 17322317, 18485070, 21402078, 23046954, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15231791, 16207915, 17015645, 17322317, 18485070, 21402078, 23046954, 26735940; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcription repressor of cydABCD and yjlC-ndh expression" /protein_id="NP_388478.1" /db_xref="EnsemblGenomes-Gn:BSU05970" /db_xref="EnsemblGenomes-Tr:CAB12416" /db_xref="GOA:O05521" /db_xref="InterPro:IPR003781" /db_xref="InterPro:IPR009718" /db_xref="InterPro:IPR022876" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2VT2" /db_xref="PDB:2VT3" /db_xref="SubtiList:BG12205" /db_xref="UniProtKB/Swiss-Prot:O05521" /translation="MNKDQSKIPQATAKRLPLYYRFLKNLHASGKQRVSSAELSDAVK VDSATIRRDFSYFGALGKKGYGYNVDYLLSFFRKTLDQDEMTDVILIGVGNLGTAFLH YNFTKNNNTKISMAFDINESKIGTEVGGVPVYNLDDLEQHVKDESVAILTVPAVAAQS ITDRLVALGIKGILNFTPARLNVPEHIRIHHIDLAVELQSLVYFLKHYSVLEEIE*" /label="rex CDS" gene 608149..608796 /gene="rex" /locus_tag="BSU_05970" /old_locus_tag="BSU05970" /label="rex gene" promotor_no_box 608626..608726 /Source="Nicolas_upshift_promotors" /id="U464" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.386613386613387" /psig="0.386613386613387" /xcortree=511 /SigmaFactorBS="tccattacagacagattggtcgcattaggaatcaagggaatc cttaattttacgccggcccgtttgaatgtgccggaacacattcgaattcatcatatag a" /listShort="tatAY, tatCY" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 608686 /Source="Nicolas_upshifts" /id="U464" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.386613386613387" /psig="0.386613386613387" /xcortree=511 /SigmaFactorBS="tccattacagacagattggtcgcattaggaatcaagggaatc cttaattttacgccggcccgtttgaatgtgccggaacacattcgaattcatcatatag a" /listShort="tatAY, tatCY" /GFF_Attribute="listLong" /label="upshifts" CDS 608818..608991 /gene="tatAY" /locus_tag="BSU_05980" /old_locus_tag="BSU05980" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15187182, 19049517, 22041895, 22544248, 24652282, 26239117, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15187182, 19049517, 22041895, 22544248, 24652282, 26239117, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="component of the twin-arginine pre-protein translocation pathway" /protein_id="NP_388479.1" /db_xref="EnsemblGenomes-Gn:BSU05980" /db_xref="EnsemblGenomes-Tr:CAB12417" /db_xref="GOA:O05522" /db_xref="InterPro:IPR003369" /db_xref="InterPro:IPR006312" /db_xref="SubtiList:BG12206" /db_xref="UniProtKB/Swiss-Prot:O05522" /translation="MPIGPGSLAVIAIVALIIFGPKKLPELGKAAGDTLREFKNATKG LTSDEEEKKKEDQ*" /label="tatAY CDS" gene 608818..608991 /gene="tatAY" /locus_tag="BSU_05980" /old_locus_tag="BSU05980" /label="tatAY gene" CDS 608998..609762 /gene="tatCY" /locus_tag="BSU_05990" /old_locus_tag="BSU05990" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11007775, 15187182, 15849754, 16850406, 19049517, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11007775, 15187182, 15849754, 16850406, 19049517, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="component of the twin-arginine pre-protein translocation pathway" /protein_id="NP_388480.1" /db_xref="EnsemblGenomes-Gn:BSU05990" /db_xref="EnsemblGenomes-Tr:CAB12418" /db_xref="GOA:O05523" /db_xref="InterPro:IPR002033" /db_xref="InterPro:IPR019820" /db_xref="SubtiList:BG12207" /db_xref="UniProtKB/Swiss-Prot:O05523" /translation="MTRMKVNQMSLLEHIAELRKRLLIVALAFVVFFIAGFFLAKPII VYLQETDEAKQLTLNAFNLTDPLYVFMQFAFIIGIVLTSPVILYQLWAFVSPGLYEKE RKVTLSYIPVSILLFLAGLSFSYYILFPFVVDFMKRISQDLNVNQVIGINEYFHFLLQ LTIPFGLLFQMPVILMFLTRLGIVTPMFLAKIRKYAYFTLLVIAALITPPELLSHMMV TVPLLILYEISILISKAAYRKAQKSSAADRDVSSGQ*" /label="tatCY CDS" gene 608998..609762 /gene="tatCY" /locus_tag="BSU_05990" /old_locus_tag="BSU05990" /label="tatCY gene" downshifts 609742 /Source="Nicolas_upshifts" /id="D290" /incds=0 /nref=151 /ntot=251 /MaxReadThrough="4.01237" /MaxDrop="6.80817" /score="19.4098216" /energy="-12.7" /TU="NA" /idTUdmin="U461" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(609800..609991) /gene="ydiK" /locus_tag="BSU_06000" /old_locus_tag="BSU06000" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388481.1" /db_xref="EnsemblGenomes-Gn:BSU06000" /db_xref="EnsemblGenomes-Tr:CAB12419" /db_xref="GOA:O05524" /db_xref="InterPro:IPR025426" /db_xref="SubtiList:BG12208" /db_xref="UniProtKB/Swiss-Prot:O05524" /translation="MRNPVVWGMIYFAVGCIFTYLAASSPGSMWSFYSILLMVFAAYN ISISFKMFAFSFKIKKNQK*" /label="ydiK CDS" gene complement(609800..609991) /gene="ydiK" /locus_tag="BSU_06000" /old_locus_tag="BSU06000" /label="ydiK gene" downshifts complement(609817) /Source="Nicolas_upshifts" /id="D291" /incds=0 /nref=211 /ntot=258 /MaxReadThrough="0.81338" /MaxDrop="6.43897" /score="25.5376889" /energy="-12.7" /TU="NA" /idTUdmin="U467" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" CDS complement(609988..610722) /gene="ydiL" /locus_tag="BSU_06010" /old_locus_tag="BSU06010" /EC_number="3.4.-.-" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane protease" /protein_id="NP_388482.1" /db_xref="EnsemblGenomes-Gn:BSU06010" /db_xref="EnsemblGenomes-Tr:CAB12420" /db_xref="GOA:O05525" /db_xref="InterPro:IPR003675" /db_xref="SubtiList:BG12209" /db_xref="UniProtKB/Swiss-Prot:O05525" /translation="MRKQYWFIILTYIIMQFSALIAIPLLFKFGYAGGQPTDENMLHA QGLWSVISFIACLVVVLLILRTVPKETLRNGQKDSIGLSILWAIAGFFIALFSQGIAG SIEYYVFGIGRESENTQAILDVIQAVPLMIIVSSIVGPILEEIIFRKIIFGALYEKTN FFFAGLISSVIFGIVHADLKHLLLYTAMGFTFAFLYARTKRIWVPIFAHLMMNTFVVI MQLEPVRNYLEQQSTQMQLIIGGLFL*" /label="ydiL CDS" gene complement(609988..610722) /gene="ydiL" /locus_tag="BSU_06010" /old_locus_tag="BSU06010" /label="ydiL gene" promotor_-35 610380..610385 /Source="Nicolas_upshift_promotors" /id="U465" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.952047952047952" /psig="0.952047952047952" /xcortree=1034 /SigmaFactorBS="tgcctgaatgacatccagaatcgcttgtgtattttctgATTC TCttccgatgccaaaaACATAATATTCAATAGAGCctgctattccttgagagaaaagg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 610400..610418 /Source="Nicolas_upshift_promotors" /id="U465" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.952047952047952" /psig="0.952047952047952" /xcortree=1034 /SigmaFactorBS="tgcctgaatgacatccagaatcgcttgtgtattttctgATTC TCttccgatgccaaaaACATAATATTCAATAGAGCctgctattccttgagagaaaagg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 610402 /Source="Nicolas_upshifts" /id="U465" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.952047952047952" /psig="0.952047952047952" /xcortree=1034 /SigmaFactorBS="tgcctgaatgacatccagaatcgcttgtgtattttctgATTC TCttccgatgccaaaaACATAATATTCAATAGAGCctgctattccttgagagaaaagg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 610721..610722 /Source="Nicolas_upshift_promotors" /id="U466" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.508491508491508" /psig="0.237762237762238" /xcortree=1461 /SigmaFactorBS="aaaataataaaccaatactgttttctcAAatggtatgtACTC CTTTGTTAAGTgggtttcgttcatctacagctattgtaacataatcggtacgggggtg a" /listShort="S207" /listLong="S208, groES, groEL, S209, S210, ydiM, S211, ydzU, ydzV, S212, S213, ydiO, ydiP" /label="promotor_-35" promotor_-10 610732..610746 /Source="Nicolas_upshift_promotors" /id="U466" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.508491508491508" /psig="0.237762237762238" /xcortree=1461 /SigmaFactorBS="aaaataataaaccaatactgttttctcAAatggtatgtACTC CTTTGTTAAGTgggtttcgttcatctacagctattgtaacataatcggtacgggggtg a" /listShort="S207" /listLong="S208, groES, groEL, S209, S210, ydiM, S211, ydzU, ydzV, S212, S213, ydiO, ydiP" /label="promotor_-10" upshifts 610754 /Source="Nicolas_upshifts" /id="U466" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.508491508491508" /psig="0.237762237762238" /xcortree=1461 /SigmaFactorBS="aaaataataaaccaatactgttttctcAAatggtatgtACTC CTTTGTTAAGTgggtttcgttcatctacagctattgtaacataatcggtacgggggtg a" /listShort="S207" /listLong="S208, groES, groEL, S209, S210, ydiM, S211, ydzU, ydzV, S212, S213, ydiO, ydiP" /label="upshifts" promotor_-10 complement(610759..610778) /Source="Nicolas_upshift_promotors" /id="U467" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.671328671328671" /psig=1 /xcortree=2332 /SigmaFactorBS="tcacgcttacatcattcttttccgctcccttttccgttagct TTTTCAcccccgtaccgatTATGTTACAATAGCTGTAGAtgaacgaaacccacttaac a" /listShort="ydiL, ydiK" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 610776..610884 /Source="Nicolas_S_feature" /locus_tag="new_649718_649826" /HighExp="S4, S5, H2O2, S3, S8, S6, Diami, Oxctl, G180, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.238" /TUlongSig="NA" /TUlongPSig="NA" /label="S207" upshifts complement(610779) /Source="Nicolas_upshifts" /id="U467" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.671328671328671" /psig=1 /xcortree=2332 /SigmaFactorBS="tcacgcttacatcattcttttccgctcccttttccgttagct TTTTCAcccccgtaccgatTATGTTACAATAGCTGTAGAtgaacgaaacccacttaac a" /listShort="ydiL, ydiK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(610792..610797) /Source="Nicolas_upshift_promotors" /id="U467" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.671328671328671" /psig=1 /xcortree=2332 /SigmaFactorBS="tcacgcttacatcattcttttccgctcccttttccgttagct TTTTCAcccccgtaccgatTATGTTACAATAGCTGTAGAtgaacgaaacccacttaac a" /listShort="ydiL, ydiK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 610858..610864 /Source="Nicolas_upshift_promotors" /id="U468" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.495504495504495" /psig="0.999000999001" /xcortree=2363 /SigmaFactorBS="tgatgtaagcgtgaaaaattttttatcttatcACTTGAAatt ggaagggagaTTCTTTATTATAAGAATTGTgttagcactctttagtgctgagtgctaa a" /listShort="S208, groES, groEL, S209, S210, ydiM, S211, ydzU, ydzV, S212, S213, ydiO, ydiP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 610878..610897 /Source="Nicolas_upshift_promotors" /id="U468" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.495504495504495" /psig="0.999000999001" /xcortree=2363 /SigmaFactorBS="tgatgtaagcgtgaaaaattttttatcttatcACTTGAAatt ggaagggagaTTCTTTATTATAAGAATTGTgttagcactctttagtgctgagtgctaa a" /listShort="S208, groES, groEL, S209, S210, ydiM, S211, ydzU, ydzV, S212, S213, ydiO, ydiP" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 610886..610960 /Source="Nicolas_S_feature" /locus_tag="new_649828_649902" /HighExp="HiTm, Etha, dia15, Heat, C90, dia5, LoTm, Lbexp, H2O2, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="Sig-" /TUlongPSig="0.238" /label="S208" upshifts 610886 /Source="Nicolas_upshifts" /id="U468" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.495504495504495" /psig="0.999000999001" /xcortree=2363 /SigmaFactorBS="tgatgtaagcgtgaaaaattttttatcttatcACTTGAAatt ggaagggagaTTCTTTATTATAAGAATTGTgttagcactctttagtgctgagtgctaa a" /listShort="S208, groES, groEL, S209, S210, ydiM, S211, ydzU, ydzV, S212, S213, ydiO, ydiP" /GFF_Attribute="listLong" /label="upshifts" CDS 610961..611245 /gene="groES" /locus_tag="BSU_06020" /old_locus_tag="BSU06020" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11407116, 17031040, 9303302" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11407116, 17031040, 9303302; Product type f: factor" /codon_start=1 /transl_table=11 /product="chaperonin small subunit" /protein_id="NP_388483.2" /db_xref="EnsemblGenomes-Gn:BSU06020" /db_xref="EnsemblGenomes-Tr:CAB12421" /db_xref="GOA:P28599" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR018369" /db_xref="InterPro:IPR020818" /db_xref="InterPro:IPR037124" /db_xref="SubtiList:BG10422" /db_xref="UniProtKB/Swiss-Prot:P28599" /translation="MLKPLGDRVVIELVESEEKTASGIVLPDSAKEKPQEGKIVAAGS GRVLESGERVALEVKEGDRIIFSKYAGTEVKYEGTEYLILRESDILAVIG*" /label="groES CDS" gene 610961..611245 /gene="groES" /locus_tag="BSU_06020" /old_locus_tag="BSU06020" /label="groES gene" CDS 611292..612926 /gene="groEL" /locus_tag="BSU_06030" /old_locus_tag="BSU06030" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:9303302, 11407116, 17031040, 17420574, 22268681" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9303302, 11407116, 17031040, 17420574, 22268681; Product type f: factor" /codon_start=1 /transl_table=11 /product="chaperonin large subunit" /protein_id="NP_388484.1" /db_xref="EnsemblGenomes-Gn:BSU06030" /db_xref="EnsemblGenomes-Tr:CAB12422" /db_xref="GOA:P28598" /db_xref="InterPro:IPR001844" /db_xref="InterPro:IPR002423" /db_xref="InterPro:IPR018370" /db_xref="InterPro:IPR027409" /db_xref="InterPro:IPR027410" /db_xref="InterPro:IPR027413" /db_xref="SubtiList:BG10423" /db_xref="UniProtKB/Swiss-Prot:P28598" /translation="MAKEIKFSEEARRAMLRGVDALADAVKVTLGPKGRNVVLEKKFG SPLITNDGVTIAKEIELEDAFENMGAKLVAEVASKTNDVAGDGTTTATVLAQAMIREG LKNVTAGANPVGVRKGMEQAVAVAIENLKEISKPIEGKESIAQVAAISAADEEVGSLI AEAMERVGNDGVITIEESKGFTTELEVVEGMQFDRGYASPYMVTDSDKMEAVLDNPYI LITDKKITNIQEILPVLEQVVQQGKPLLLIAEDVEGEALATLVVNKLRGTFNAVAVKA PGFGDRRKAMLEDIAVLTGGEVITEDLGLDLKSTQIAQLGRASKVVVTKENTTIVEGA GETDKISARVTQIRAQVEETTSEFDREKLQERLAKLAGGVAVIKVGAATETELKERKL RIEDALNSTRAAVEEGIVSGGGTALVNVYNKVAAVEAEGDAQTGINIVLRALEEPIRQ IAHNAGLEGSVIVERLKNEEIGVGFNAATGEWVNMIEKGIVDPTKVTRSALQNAASVA AMFLTTEAVVADKPEENGGGAGMPDMGGMGGMGGMM*" /label="groEL CDS" gene 611292..612926 /gene="groEL" /locus_tag="BSU_06030" /old_locus_tag="BSU06030" /label="groEL gene" S_feature 612927..613019 /Source="Nicolas_S_feature" /locus_tag="new_651869_651961" /HighExp="HiTm, Etha, dia15, Heat, Diami, dia5, C90, S1, S2, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="Sig-" /TUlongPSig="0.238" /label="S209" downshifts 612976 /Source="Nicolas_upshifts" /id="D292" /incds=0 /nref=228 /ntot=267 /MaxReadThrough="6.24882" /MaxDrop="5.77437" /score="-6.71161833" /energy="-16.3" /TU="U468" /idTUdmin="U466" /TUdmin=2112 /isTUend="FALSE" /label="downshifts" CDS complement(613014..613142) /gene="ydzTc" /locus_tag="BSU_06033" /old_locus_tag="BSU06033" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein; putative integrase (fragment); C-terminal part of YdzT; defective prophage 3" /translation="EAGVGIKEIQQQFGHSDINTTMDIYAHMTANMEKRSPNSLVN*" /label="ydzTc CDS" gene complement(613014..613142) /gene="ydzTc" /locus_tag="BSU_06033" /old_locus_tag="BSU06033" /pseudo /label="ydzTc gene" S_feature 613021..>614247 /Source="Nicolas_S_feature" /locus_tag="new_651963_653431" /HighExp="H2O2, Heat, dia15, Diami, S1, G135, G150, S2, G180, dia5" /AntisenseName="ydzT" /AntisenseCor="-2.9485116084752801E-2" /AntisenseRegPval="-0.2" /CDS_PredictionProba="0.23100000000000001" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="Sig-" /TUlongPSig="0.238" /label="S210" CDS complement(613145..613303) /gene="ydzT" /locus_tag="BSU_06034" /old_locus_tag="BSU06034" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein; putative integrase (fragment); internal part of YdzT" /db_xref="PSEUDO:CAX52563.1" /translation="MIYQDSSFIFEREDGHPQLRKVIETRLKRLLKKAGIKRMSPPTL LGIPIPPY*" /label="ydzT CDS" gene complement(613145..613303) /gene="ydzT" /locus_tag="BSU_06034" /old_locus_tag="BSU06034" /pseudo /label="ydzT gene" CDS complement(613348..613476) /gene="ydzT" /locus_tag="BSU_06036" /old_locus_tag="BSU06036" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein; putative integrase (fragment); internal part of YdzT" /db_xref="PSEUDO:CAX52564.1" /translation="MISQVTKTLYTPNNQIEKYQLLTPKTTGSVDIVRIDETMSIY*" /label="ydzT CDS" gene complement(613348..613476) /gene="ydzT" /locus_tag="BSU_06036" /old_locus_tag="BSU06036" /pseudo /label="ydzT gene" CDS complement(613569..613778) /gene="ydzT" /locus_tag="BSU_06037" /old_locus_tag="BSU06037" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; Product type e : enzyme" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein; putative integrase (fragment); internal part of YdzT" /db_xref="PSEUDO:CAX52565.1" /translation="MYEDRTLELNEQYSHNCLGGIHACGRMIFRKAKTQGIIKMNPTG DFQLPKKQQSIGKRGADTFSKARSI*" /label="ydzT CDS" gene complement(613569..613778) /gene="ydzT" /locus_tag="BSU_06037" /old_locus_tag="BSU06037" /pseudo /label="ydzT gene" CDS complement(613771..614076) /gene="ydzTn" /locus_tag="BSU_06038" /old_locus_tag="BSU06038" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein; putative integrase (fragment); N-terminal part of YdzT; defective prophage 3" /db_xref="PSEUDO:CAX52566.1" /translation="MELSYLLGIDPLTKKRLEISKGRFKTKKEAPVAARHVELQNDNG TFIKESDMPFKTFAKGWLKIYNRSGVKISSVRASEKKMMHFIAVLGQYPISKTQKNV* " /label="ydzTn CDS" gene complement(613771..614076) /gene="ydzTn" /locus_tag="BSU_06038" /old_locus_tag="BSU06038" /pseudo /label="ydzTn gene" SCAR join(614247,614254) /created_by="AR/SM" /note="deletion occured in betwen marked nucleotides" /label="Delta6_1" N_region 614248..614253 /note="KpnI site (GGTACC)" /created_by="User" /label="Delta6_1" CDS complement(614352..616841) /gene="gutR" /locus_tag="BSU_06140" /old_locus_tag="BSU06140" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11118449, 11390381, 12897001" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11118449, 11390381, 12897001; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of the glucitol operon" /protein_id="NP_388495.1" /db_xref="EnsemblGenomes-Gn:BSU06140" /db_xref="EnsemblGenomes-Tr:CAB12433" /db_xref="GOA:P39143" /db_xref="InterPro:IPR002182" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="InterPro:IPR024123" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10178" /db_xref="UniProtKB/Swiss-Prot:P39143" /translation="MAELENRKQFAQMLAPGVKTLKLHPDYKVRRKKNEKTGQSYIDK IALQLGVSPNTIKSWIGQMGANYIPGRIDDGKLFGMIWIILEKTDLDIEWLTDLLEAT TIPVIKPALPVWAASCLKKAKILRKDGLFGAPSEGEIENVVKRLFHDRPGQETNALTE QPITHNLPSRWSGRFIGRSFDMEAIRQWMLSPSPVCLITGWAGMGKTTIALEAAYSCV DDTSVWPAFNSIIWVSADWKGLSFSDFLNTIAYQLGRKEQIDKSINVKRFVVRNALAN YTREKPILLIVDSIDTAERDIHEFITSLPQGVKVLLTARENVKQTYRESFGEMTAIQL SGLDQTDAHEFFQQEVHHCLQTCNLPRKREKLEQLLHLSSDLKNEFISATAGNPKAMA LSIAYMSDDDIPAQQLIHELGKAGYSLLELFEFLFGRTWDRCNEDTRKLWQTLCFFSK PPDEKSLAAAAGLDARRFHYAMEQMRSYALIQPERSQGRTQYLAHQTVVAYGEQHLSE QHEYEKEARNRWAHYYIDYAETHLKREQPNSIYWSYLLGRNLDQMKQEWPNILKVIQW ASETEQKEILIELITRISHFLSRINLPLRIEYGRKAADAAHHLGQHTREAYFRIDTSG WALMEVNDLDGALQQIEAGLKILEQSDAHDAYDLKVWGHALKARLFLKDGQQEKAETI LNEIENQPISPTIQHRVLLVRGDLSFARGYHVEAIQLYEAANEISSTYGGEKTIEAYF NLGVAYVKCDQFEKAEEAFEQMLYDKHNANQVELIYYHYGMAQLLYRKGEKTKAVESN QKAIRLIDSWEPAIGIRGEVERLARATKENE*" /label="gutR CDS" gene complement(614352..616841) /gene="gutR" /locus_tag="BSU_06140" /old_locus_tag="BSU06140" /label="gutR gene" downshifts complement(614374) /Source="Nicolas_upshifts" /id="D298" /incds=0 /nref=56 /ntot=209 /MaxReadThrough="0.69715" /MaxDrop="4.256" /score="0.285109352" /energy="-13.9" /TU="NA" /idTUdmin="U474" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(616855..616874) /Source="Nicolas_upshift_promotors" /id="U474" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.573426573426573" /psig="0.995004995004995" /xcortree=2305 /SigmaFactorBS="ctttcctgctgtataaaaggacagcggcactgtacttttatt ttttCATATACAaaaaacgctggatTGATAAAATAGTACTAATAGgaggtgcaggctt a" /listShort="gutR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(616881) /Source="Nicolas_upshifts" /id="U474" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.573426573426573" /psig="0.995004995004995" /xcortree=2305 /SigmaFactorBS="ctttcctgctgtataaaaggacagcggcactgtacttttatt ttttCATATACAaaaaacgctggatTGATAAAATAGTACTAATAGgaggtgcaggctt a" /listShort="gutR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(616888..616895) /Source="Nicolas_upshift_promotors" /id="U474" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.573426573426573" /psig="0.995004995004995" /xcortree=2305 /SigmaFactorBS="ctttcctgctgtataaaaggacagcggcactgtacttttatt ttttCATATACAaaaaacgctggatTGATAAAATAGTACTAATAGgaggtgcaggctt a" /listShort="gutR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 616944..616945 /Source="Nicolas_upshift_promotors" /id="U475" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.481518481518482" /psig="0.848151848151848" /xcortree=335 /SigmaFactorBS="aataaaagtacagtgccgctgtccttttatacagcaggaaag gcTGttgaacgtgttaaaaAGCAGATAAAATGGGGGCAGtaacagagaaaacaaaaat g" /listShort="S220, gutB, gutP, ydjE" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 616960..617042 /Source="Nicolas_S_feature" /locus_tag="new_667383_667465" /HighExp="Lbstat, BI, M40t90, Mt0, M0t90, dia5, dia0, Lbexp, Lbtran, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.848" /TUlongSig="NA" /TUlongPSig="NA" /label="S220" upshifts 616960 /Source="Nicolas_upshifts" /id="U475" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.481518481518482" /psig="0.848151848151848" /xcortree=335 /SigmaFactorBS="aataaaagtacagtgccgctgtccttttatacagcaggaaag gcTGttgaacgtgttaaaaAGCAGATAAAATGGGGGCAGtaacagagaaaacaaaaat g" /listShort="S220, gutB, gutP, ydjE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 616961..616980 /Source="Nicolas_upshift_promotors" /id="U475" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.481518481518482" /psig="0.848151848151848" /xcortree=335 /SigmaFactorBS="aataaaagtacagtgccgctgtccttttatacagcaggaaag gcTGttgaacgtgttaaaaAGCAGATAAAATGGGGGCAGtaacagagaaaacaaaaat g" /listShort="S220, gutB, gutP, ydjE" /GFF_Attribute="listLong" /label="promotor_-10" CDS 617043..618104 /gene="gutB" /locus_tag="BSU_06150" /old_locus_tag="BSU06150" /EC_number="1.1.1.14" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1460002, 8195086, 8195087, 12897001, 19784641" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1460002, 8195086, 8195087, 12897001, 19784641; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucitol (sorbitol) dehydrogenase" /protein_id="NP_388496.1" /db_xref="EnsemblGenomes-Gn:BSU06150" /db_xref="EnsemblGenomes-Tr:CAB12434" /db_xref="GOA:Q06004" /db_xref="InterPro:IPR002328" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR020843" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10177" /db_xref="UniProtKB/Swiss-Prot:Q06004" /translation="MTHTVPQNMKAAVMHNTREIKIETLPVPDINHDEVLIKVMAVGI CGSDLHYYTNGRIGNYVVEKPFILGHECAGEIAAVGSSVDQFKVGDRVAVEPGVTCGR CEACKEGRYNLCPDVQFLATPPVDGAFVQYIKMRQDFVFLIPDSLSYEEAALIEPFSV GIHAAARTKLQPGSTIAIMGMGPVGLMAVAAAKAFGAGTIIVTDLEPLRLEAAKKMGA THIINIREQDALEEIKTITNDRGVDVAWETAGNPAALQSALASVRRGGKLAIVGLPSQ NEIPLNVPFIADNEIDIYGIFRYANTYPKGIEFLASGIVDTKHLVTDQYSLEQTQDAM ERALQFKNECLKVMVYPNR*" /label="gutB CDS" gene 617043..618104 /gene="gutB" /locus_tag="BSU_06150" /old_locus_tag="BSU06150" /label="gutB gene" CDS 618178..619569 /gene="gutP" /locus_tag="BSU_06160" /old_locus_tag="BSU06160" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12897001, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="H+-glucitol symporter; prophage region 3" /protein_id="NP_388497.1" /db_xref="EnsemblGenomes-Gn:BSU06160" /db_xref="EnsemblGenomes-Tr:CAB12435" /db_xref="GOA:O34368" /db_xref="InterPro:IPR001927" /db_xref="InterPro:IPR018043" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12795" /db_xref="UniProtKB/Swiss-Prot:O34368" /translation="MIGTEKVTALKAKHQSKSSTGLSWFERIGYGFGDMSYNIIFQFV NAYLLFYYTDVGGIQPAVIATLFLVVRVLDAIFDPIMGLILDKTNTRWGKARPYLLWV AFPFALFTFLCFTTPHFGETGNMVYAYVTYILLGMSFSMQTIPVNSLTGRMTNSVEER TVLTTTRMILVYIGILLSISCATPLATAIGGEDQAFGFQMTALIYAAVSIVLNLFSFF TVRERIQPKKRKKQGIKKTLSVLFKNKPLLMLISSFLAFAIGFNIKLSTMVYYFTYNV NHKEFVFMGTVLFFGAALISNLFIPFFSEKWGRKQVMIITAALSLISYAGLHFTPYSS IPLIFIWLFASGFFTTPLNTLAWGMVADCVDYAEWKTGIRADGVVISSMSFINKLGVA LAGSFSAIYLGIAGYVANTDQTVASLNAIKNMNALIPGFFILLSIILIAFYPLTEKRY KHIISELEQRSAR*" /label="gutP CDS" gene 618178..619569 /gene="gutP" /locus_tag="BSU_06160" /old_locus_tag="BSU06160" /label="gutP gene" promotor_-35 619596..619603 /Source="Nicolas_upshift_promotors" /id="U476" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.871128871128871" /psig="0.997002997002997" /xcortree=489 /SigmaFactorBS="cgagataaatagatgtaaaatttttaatattcaaTGTTGTAT ttatggcaaaaagTAATATACTGAGACTGTAATctagactttataaatgagtgtgata a" /listShort="ydjE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 619617..619636 /Source="Nicolas_upshift_promotors" /id="U476" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.871128871128871" /psig="0.997002997002997" /xcortree=489 /SigmaFactorBS="cgagataaatagatgtaaaatttttaatattcaaTGTTGTAT ttatggcaaaaagTAATATACTGAGACTGTAATctagactttataaatgagtgtgata a" /listShort="ydjE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 619622 /Source="Nicolas_upshifts" /id="U476" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.871128871128871" /psig="0.997002997002997" /xcortree=489 /SigmaFactorBS="cgagataaatagatgtaaaatttttaatattcaaTGTTGTAT ttatggcaaaaagTAATATACTGAGACTGTAATctagactttataaatgagtgtgata a" /listShort="ydjE" /GFF_Attribute="listLong" /label="upshifts" CDS 619664..620626 /gene="ydjE" /locus_tag="BSU_06170" /old_locus_tag="BSU06170" /EC_number="2.7.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 26483775, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sugar kinase (ribokinase family); prophage region 3" /protein_id="NP_388498.1" /db_xref="EnsemblGenomes-Gn:BSU06170" /db_xref="EnsemblGenomes-Tr:CAB12436" /db_xref="GOA:O34768" /db_xref="InterPro:IPR002173" /db_xref="InterPro:IPR011611" /db_xref="InterPro:IPR029056" /db_xref="SubtiList:BG12796" /db_xref="UniProtKB/Swiss-Prot:O34768" /translation="MRSHSVVCIGELLIDFFCTDVDVDLMEGRQFLKSAGGAPANVSA AIAKLGGDAAFSGKVGKDPFGYFLKRTLDAVHVDTSMLVMDEKAPTTLAFVSLKQNGE RDFVFNRGADALFTLEDIDQEKLNEAKILHFGSATALLSDPFCSAYLRLMSIAKDNGQ FISFDPNYREDLWRGRVSEFVSVAKKAIAVSDFVKVSDEELEIISGVKDHEKGVAILH EIGANIVAVTLGKSGTLLSNGKDREIIPSIPVTSIDSTGAGDAFVGAALYQLANTDQI QSVDADFVKLREIVAFANKVGALVCTKIGAIDALPSLDEIGVSL*" /label="ydjE CDS" gene 619664..620626 /gene="ydjE" /locus_tag="BSU_06170" /old_locus_tag="BSU06170" /label="ydjE gene" downshifts 620611 /Source="Nicolas_upshifts" /id="D299" /incds=0 /nref=86 /ntot=213 /MaxReadThrough="2.99546" /MaxDrop="4.52045" /score="16.4550614" /energy="-14" /TU="NA" /idTUdmin="U475" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 620751..620760 /Source="Nicolas_upshift_promotors" /id="U477" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1663 /SigmaFactorBS="agttgtatattttttgtttgaaatgtcattttttattaaaaa agTGAAACTTTTaacgataataaaTAGTATATGTAACAAGggttaccgaattagcttt a" /listShort="pspA, S221, ydjG, ydjH, ydjI" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 620767 /Source="Nicolas_upshifts" /id="U477" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1663 /SigmaFactorBS="agttgtatattttttgtttgaaatgtcattttttattaaaaa agTGAAACTTTTaacgataataaaTAGTATATGTAACAAGggttaccgaattagcttt a" /listShort="pspA, S221, ydjG, ydjH, ydjI" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 620773..620788 /Source="Nicolas_upshift_promotors" /id="U477" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1663 /SigmaFactorBS="agttgtatattttttgtttgaaatgtcattttttattaaaaa agTGAAACTTTTaacgataataaaTAGTATATGTAACAAGggttaccgaattagcttt a" /listShort="pspA, S221, ydjG, ydjH, ydjI" /GFF_Attribute="listLong" /label="promotor_-10" CDS 620822..621505 /gene="pspA" /locus_tag="BSU_06180" /old_locus_tag="BSU06180" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:11454200" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11454200; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="phage shock protein A homolog regulator; prophage region 3" /protein_id="NP_388499.1" /db_xref="EnsemblGenomes-Gn:BSU06180" /db_xref="EnsemblGenomes-Tr:CAB12437" /db_xref="GOA:P54617" /db_xref="InterPro:IPR007157" /db_xref="SubtiList:BG12797" /db_xref="UniProtKB/Swiss-Prot:P54617" /translation="MSIIGRFKDIMSANINALLDKAENPEKMVDQYLRNMNSDLAKVK AETAAVMAEEQRAKREYHECQADMEKMESYAMKALQAGNESDARKFLERKTSLESKLS ELQAANQIAATNAAQMRKMHDKLVSDIGELEARKNMIKAKWAVAKTQERMNKLGASVS STSQSMSAFGRMEDKVNKALDQANAMAELNSAPQDDMADLSAKYDTGGSSQVDDELAA LKAKMMLDK*" /label="pspA CDS" gene 620822..621505 /gene="pspA" /locus_tag="BSU_06180" /old_locus_tag="BSU06180" /label="pspA gene" S_feature 621506..621570 /Source="Nicolas_S_feature" /locus_tag="new_671929_671993" /HighExp="Salt, S0, aero, T-0.40H, T-1.40H, SMMPr, T-1.10H, T0.0H, Cold, GM 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S221" CDS 621571..622596 /gene="ydjG" /locus_tag="BSU_06190" /old_locus_tag="BSU06190" /function="16.5: Explore" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative phage replication protein; prophage region 3" /protein_id="NP_388500.1" /db_xref="EnsemblGenomes-Gn:BSU06190" /db_xref="EnsemblGenomes-Tr:CAB12438" /db_xref="GOA:O34434" /db_xref="InterPro:IPR013137" /db_xref="SubtiList:BG12798" /db_xref="UniProtKB/Swiss-Prot:O34434" /translation="MIISYKCPNCGSDMAFDSETGSLSCSSCGRQDNIESLPKENIAA RFSDDEAKEYQCKNCGAVLITEAETTATTCSFCGGAAILADRLSGHLAPAKVIPFTIS KQEAEQAFRKWCKKGLLTPRGFMSADRIKSITGMYIPFWMFDLNSEVQVRANCTRVHQ YEEGDYICTETEHFEAFRDINLDYLKIPVDASEKMKDELMDKLEPYSYEELKDFQTAY LAGYIAEKYNYTDEELFPRAKEKISSYIDSYIHSTFSGYTSVNVRDKHIHTKNVNSFY VLLPVWMVSYDYERAEHIFAMNGQTGKVVGKPPISRGKVAAWFSGIAGGTFLALKLVS LMMGGGF*" /label="ydjG CDS" gene 621571..622596 /gene="ydjG" /locus_tag="BSU_06190" /old_locus_tag="BSU06190" /label="ydjG gene" CDS 622596..623360 /gene="ydjH" /locus_tag="BSU_06200" /old_locus_tag="BSU06200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; prophage region 3" /protein_id="NP_388501.1" /db_xref="EnsemblGenomes-Gn:BSU06200" /db_xref="EnsemblGenomes-Tr:CAB12439" /db_xref="GOA:O35004" /db_xref="InterPro:IPR007621" /db_xref="SubtiList:BG12799" /db_xref="UniProtKB/Swiss-Prot:O35004" /translation="MRGFFGKAIFVVLAVFIMMPLLGIEAVRASELQQHVYDRAHLLS KAEIGKLESLSAKLGAKRDTDFIIITTKSTNGEDIADYTGDFYDRYGKGSTAILTIDM TNREVFIAGFKKAEQYLDNSRLNSIRNTISSDLSNENYFEAFETYIQLSYKDMGIKPG VNPDNIFFTWWFQLIAAIAVGGIAVSIMLYHAGGKVTVNGSTYMDQRTSDVIDQYDTY IRTTVTRERKPSDKDSGSDGGVTKGGTSYSGSRGSF*" /label="ydjH CDS" gene 622596..623360 /gene="ydjH" /locus_tag="BSU_06200" /old_locus_tag="BSU06200" /label="ydjH gene" CDS 623391..624362 /gene="ydjI" /locus_tag="BSU_06210" /old_locus_tag="BSU06210" /function="16.5: Explore" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative phage protein" /protein_id="NP_388502.1" /db_xref="EnsemblGenomes-Gn:BSU06210" /db_xref="EnsemblGenomes-Tr:CAB12440" /db_xref="InterPro:IPR033880" /db_xref="InterPro:IPR036013" /db_xref="SubtiList:BG12800" /db_xref="UniProtKB/Swiss-Prot:O34789" /translation="MSFFRNQLANVVEWEEFRDDMIFYKWNNREIKKGSRLIIRPGQD AVFLNNGRVEGVFQDDGDYDIESEIIPFLSTLKGFKFGFNSGMRAEVLFVNTKEFTVR WGTKQAINIPAAGMPGGMPIRANGTFNFKVQDYISLIDKIAGVKDQYFVEDIKTRIIS ILDQLLMKWITREGKDMFNLQANAFDIAKGIQEDLDMQLISDGMTVTGFQIMSFNYPQ EVQDMITKNASYGMVGDVNRYQQISMTDGMASGKMSGSGAASDMAGMMMGMNMANQMM NQMNQNQQAQSSGPQSTGSGSKPNFCPNCGTKTGEANFCPNCGQKLV*" /label="ydjI CDS" gene 623391..624362 /gene="ydjI" /locus_tag="BSU_06210" /old_locus_tag="BSU06210" /label="ydjI gene" downshifts 624352 /Source="Nicolas_upshifts" /id="D300" /incds=0 /nref=180 /ntot=247 /MaxReadThrough="2.71622" /MaxDrop="5.81579" /score="16.72046" /energy="-11.1" /TU="U477" /idTUdmin="U477" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" downshifts 624396 /Source="Nicolas_upshifts" /id="D301" /incds=0 /nref=1 /ntot=2 /MaxReadThrough="2.13813" /MaxDrop="3.25329" /score="16.72046" /energy="-11.1" /TU="NA" /idTUdmin="U477" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(624409..625434) /gene="ydjJ" /locus_tag="BSU_06220" /old_locus_tag="BSU06220" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative membrane associated potassium channel; prophage region 3" /protein_id="NP_388503.1" /db_xref="EnsemblGenomes-Gn:BSU06220" /db_xref="EnsemblGenomes-Tr:CAB12441" /db_xref="GOA:O34733" /db_xref="InterPro:IPR013099" /db_xref="SubtiList:BG12801" /db_xref="UniProtKB/Swiss-Prot:O34733" /translation="MNEGYIIAGLLLLTAGMIDFLWTTLWLESGAGPITRCLSAWLWK GCRKISGDHAKVLSMAGPLLLCLTLVIWISLFWSGWVLIYSSDPHSLMETQSKEPASW SDRIYFSGYVMFTLGNGDLAPNGGLWKLVTIIETAQGLLTITFSVTYLISVLSAVNQK RSFAQSVLSLGHDGTEIVHNAWNGKDFHDIDFLLVAASSELGKLTAQHNAFPILHFYH STQHQESSIIAVAVLDEALTIFKYGIPEQYQPNQLHIKEARSSIKNYLDTVHTAYIHP AEQAPPEPDISKLQQSGIPALSKQTFQIAVNSIKERRQLLLGIIQAGARKWPVQEQAI GNAYSPK*" /label="ydjJ CDS" gene complement(624409..625434) /gene="ydjJ" /locus_tag="BSU_06220" /old_locus_tag="BSU06220" /label="ydjJ gene" promotor_-10 complement(625466..625485) /Source="Nicolas_upshift_promotors" /id="U478" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=251 /SigmaFactorBS="ccacctatttttctctgtaaaatcaaacattcgttcaatTGT TTCAgactcaggataaaAGGAAATAGAGAAGAAAATAaaagaaggctgacttaaggga g" /listShort="ydjJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(625484) /Source="Nicolas_upshifts" /id="U478" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=251 /SigmaFactorBS="ccacctatttttctctgtaaaatcaaacattcgttcaatTGT TTCAgactcaggataaaAGGAAATAGAGAAGAAAATAaaagaaggctgacttaaggga g" /listShort="ydjJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(625499..625505) /Source="Nicolas_upshift_promotors" /id="U478" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=251 /SigmaFactorBS="ccacctatttttctctgtaaaatcaaacattcgttcaatTGT TTCAgactcaggataaaAGGAAATAGAGAAGAAAATAaaagaaggctgacttaaggga g" /listShort="ydjJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 625694..625701 /Source="Nicolas_upshift_promotors" /id="U479" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=323 /SigmaFactorBS="tgattttccttttatagagtaaaaaattttcagaaatttaTA TTGACTgaaagcgtttttatAATTATGATAATATCAGATAtaacaaaaatgtcactat a" /listShort="S222, iolT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 625714 /Source="Nicolas_upshifts" /id="U479" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=323 /SigmaFactorBS="tgattttccttttatagagtaaaaaattttcagaaatttaTA TTGACTgaaagcgtttttatAATTATGATAATATCAGATAtaacaaaaatgtcactat a" /listShort="S222, iolT" /GFF_Attribute="listLong" /label="upshifts" S_feature 625716..626018 /Source="Nicolas_S_feature" /locus_tag="new_676139_676441" /HighExp="M0t90, M40t90, Lbtran, T0.30H, BI, T1.0H, M9-stat, S1, T1.30H, S0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.28450700000000001" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S222" promotor_-10 625716..625735 /Source="Nicolas_upshift_promotors" /id="U479" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=323 /SigmaFactorBS="tgattttccttttatagagtaaaaaattttcagaaatttaTA TTGACTgaaagcgtttttatAATTATGATAATATCAGATAtaacaaaaatgtcactat a" /listShort="S222, iolT" /GFF_Attribute="listLong" /label="promotor_-10" CDS 626019..627440 /gene="iolT" /locus_tag="BSU_06230" /old_locus_tag="BSU06230" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11807058, 15849754, 16850406, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11807058, 15849754, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="myo-inositol transporter" /protein_id="NP_388504.1" /db_xref="EnsemblGenomes-Gn:BSU06230" /db_xref="EnsemblGenomes-Tr:CAB12442" /db_xref="GOA:O34718" /db_xref="InterPro:IPR003663" /db_xref="InterPro:IPR005828" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12802" /db_xref="UniProtKB/Swiss-Prot:O34718" /translation="MNKQGNQMSFLRTIILVSTFGGLLFGYDTGVLNGALPYMGEPDQ LNLNAFTEGLVTSSLLFGAALGAVFGGRMSDFNGRRKNILFLAVIFFISTIGCTFAPN VTVMIISRFVLGIAVGGASVTVPAYLAEMSPVESRGRMVTQNELMIVSGQLLAFVFNA ILGTTMGDNSHVWRFMLVIASLPALFLFFGMIRMPESPRWLVSKGRKEDALRVLKKIR DEKRAAAELQEIEFAFKKEDQLEKATFKDLSVPWVRRIVFIGLGIAIVQQITGVNSIM YYGTEILRNSGFQTEAALIGNIANGVISVLATFVGIWLLGRVGRRPMLMTGLIGTTTA LLLIGIFSLVLEGSPALPYVVLSLTVTFLAFQQGAISPVTWLMLSEIFPLRLRGLGMG VTVFCLWMVNFAVSFTFPILLAAIGLSTTFFIFVGLGICSVLFVKRFLPETKGLSLEQ LEENFRAYDHSGAKKDSGAEVIG*" /label="iolT CDS" gene 626019..627440 /gene="iolT" /locus_tag="BSU_06230" /old_locus_tag="BSU06230" /label="iolT gene" downshifts 627432 /Source="Nicolas_upshifts" /id="D302" /incds=0 /nref=11 /ntot=24 /MaxReadThrough="2.82455" /MaxDrop="8.02371" /score="11.3880907" /energy="-11.2" /TU="NA" /idTUdmin="U479" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(627488) /Source="Nicolas_upshifts" /id="D303" /incds=0 /nref=242 /ntot=272 /MaxReadThrough="1.00274" /MaxDrop="9.32541" /score="13.6781112" /energy="-11.2" /TU="NA" /idTUdmin="U482" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(627488..628528) /gene="bdhA" /locus_tag="BSU_06240" /old_locus_tag="BSU06240" /EC_number="1.1.1.4" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12469342, 18820069, 24525333, 26428232, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12469342, 18820069, 24525333, 26428232, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetoin reductase/2,3-butanediol dehydrogenase" /protein_id="NP_388505.1" /db_xref="EnsemblGenomes-Gn:BSU06240" /db_xref="EnsemblGenomes-Tr:CAB12443" /db_xref="GOA:O34788" /db_xref="InterPro:IPR002328" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR020843" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12803" /db_xref="UniProtKB/Swiss-Prot:O34788" /translation="MKAARWHNQKDIRIEHIEEPKTEPGKVKIKVKWCGICGSDLHEY LGGPIFIPVDKPHPLTNETAPVTMGHEFSGEVVEVGEGVENYKVGDRVVVEPIFATHG HQGAYNLDEQMGFLGLAGGGGGFSEYVSVDEELLFKLPDELSYEQGALVEPSAVALYA VRSSKLKAGDKAAVFGCGPIGLLVIEALKAAGATDIYAVELSPERQQKAEELGAIIVD PSKTDDVVAEIAERTGGGVDVAFEVTGVPVVLRQAIQSTTIAGETVIVSIWEKGAEIH PNDIVIKERTVKGIIGYRDIFPAVLSLMKEGYFSADKLVTKKIVLDDLIEEGFGALIK EKSQVKILVRPN*" /label="bdhA CDS" gene complement(627488..628528) /gene="bdhA" /locus_tag="BSU_06240" /old_locus_tag="BSU06240" /label="bdhA gene" promotor_-35 628068..628077 /Source="Nicolas_upshift_promotors" /id="U480" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1246 /SigmaFactorBS="agtttgcttgagcggacagcgtatagagcaactgcaGAAGGT TCAAcgagcgcgccttgTTCATATGATAATTCATCAGgaagtttgaacaaaagctctt c" /listShort="S223" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 628091..628110 /Source="Nicolas_upshift_promotors" /id="U480" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1246 /SigmaFactorBS="agtttgcttgagcggacagcgtatagagcaactgcaGAAGGT TCAAcgagcgcgccttgTTCATATGATAATTCATCAGgaagtttgaacaaaagctctt c" /listShort="S223" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 628092..628627 /Source="Nicolas_S_feature" /locus_tag="new_678515_679050" /HighExp="C30, Gly, S6, C90, S8, BT, S7, Sw, Fru, Lbstat" /AntisenseName="bdhA" /AntisenseCor="-0.174163895138467" /AntisenseRegPval="-2.4" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S223" upshifts 628092 /Source="Nicolas_upshifts" /id="U480" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1246 /SigmaFactorBS="agtttgcttgagcggacagcgtatagagcaactgcaGAAGGT TCAAcgagcgcgccttgTTCATATGATAATTCATCAGgaagtttgaacaaaagctctt c" /listShort="S223" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(628529..628823) /Source="Nicolas_S_feature" /locus_tag="new_678952_679246_c" /HighExp="Lbtran, BI, T1.0H, M40t90, LBGstat, LoTm, T0.30H, LPhT, Lbstat, ferm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S224" misc_feature 628628..628647 /Source="Nicolas_upshift_promotors" /id="U481" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.866133866133866" /psig="0.994005994005994" /xcortree=1752 /SigmaFactorBS="accggtcaatatgaactgttcacaaaatcgccatttttaaaa ccaaaaaagaaatgaaaTTTTTATATAATATAATCTAcgtttttttgaaaaaaagaaa c" /listShort="S225" /listLong="ydjM, ydjN" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 628629..628926 /Source="Nicolas_S_feature" /locus_tag="new_679052_679349" /HighExp="G180, Paraq, Oxctl, H2O2, G135, G150, MG 5, C30, UNK1, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S225" upshifts 628629 /Source="Nicolas_upshifts" /id="U481" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.866133866133866" /psig="0.994005994005994" /xcortree=1752 /SigmaFactorBS="accggtcaatatgaactgttcacaaaatcgccatttttaaaa ccaaaaaagaaatgaaaTTTTTATATAATATAATCTAcgtttttttgaaaaaaagaaa c" /listShort="S225" /listLong="ydjM, ydjN" /label="upshifts" misc_feature complement(628818..628832) /Source="Nicolas_upshift_promotors" /id="U482" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.598401598401598" /psig="0.99000999000999" /xcortree=3201 /SigmaFactorBS="tacaaagtcaaaaaagttacctctgctaaaataaaccatgga agattatccTATTATAATAGCAGTattagagttataattattgatagagtagttgtcg c" /listShort="S224, bdhA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(628823) /Source="Nicolas_upshifts" /id="U482" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.598401598401598" /psig="0.99000999000999" /xcortree=3201 /SigmaFactorBS="tacaaagtcaaaaaagttacctctgctaaaataaaccatgga agattatccTATTATAATAGCAGTattagagttataattattgatagagtagttgtcg c" /listShort="S224, bdhA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 628925..628944 /Source="Nicolas_upshift_promotors" /id="U483" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.462537462537463" /psig="0.998001998001998" /xcortree=3034 /SigmaFactorBS="cttttttgactttgtaacattactgtaaggatattgaaAtaa aaaatagctggttgaTCGTGTATAATCTTCCTAGAtgttaacaaacagggggacgaaa t" /listShort="ydjM, ydjN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 628928 /Source="Nicolas_upshifts" /id="U483" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.462537462537463" /psig="0.998001998001998" /xcortree=3034 /SigmaFactorBS="cttttttgactttgtaacattactgtaaggatattgaaAtaa aaaatagctggttgaTCGTGTATAATCTTCCTAGAtgttaacaaacagggggacgaaa t" /listShort="ydjM, ydjN" /GFF_Attribute="listLong" /label="upshifts" CDS 628967..629338 /gene="walM" /locus_tag="BSU_06250" /old_locus_tag="BSU06250" /experiment="publication(s) with functional evidences, PMID:17581128, 20487291" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17581128, 20487291; Product type f: factor" /codon_start=1 /transl_table=11 /product="protein involved in cell wall metabolism" /protein_id="NP_388506.1" /db_xref="EnsemblGenomes-Gn:BSU06250" /db_xref="EnsemblGenomes-Tr:CAB12444" /db_xref="InterPro:IPR009009" /db_xref="InterPro:IPR036908" /db_xref="SubtiList:BG11036" /db_xref="UniProtKB/Swiss-Prot:P40775" /translation="MLKKVILAAFILVGSTLGAFSFSSDASAKHVNGNITWYNGVGKK GSSGKKLGHWDCATKIGFDVPRNGTKIRAYAKAKPKKVITVYKNDVGRMPNAVLDVSP KAFKALGYPLSKGKVAGHYSY*" /label="walM CDS" gene 628967..629338 /gene="walM" /locus_tag="BSU_06250" /old_locus_tag="BSU06250" /label="walM gene" downshifts 629324 /Source="Nicolas_upshifts" /id="D304" /incds=0 /nref=5 /ntot=52 /MaxReadThrough="5.74148" /MaxDrop="2.8439" /score="-1.55787542" /energy="-7.4" /TU="U483" /idTUdmin="U481" /TUdmin=418 /isTUend="FALSE" /label="downshifts" CDS 629404..630450 /gene="ydjN" /locus_tag="BSU_06260" /old_locus_tag="BSU06260" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="NP_388507.1" /db_xref="EnsemblGenomes-Gn:BSU06260" /db_xref="EnsemblGenomes-Tr:CAB12445" /db_xref="InterPro:IPR011659" /db_xref="InterPro:IPR015943" /db_xref="SubtiList:BG12804" /db_xref="UniProtKB/Swiss-Prot:O34353" /translation="MKKRIILLLAVIIAAAAAGVAFYVAKDKGHEKAADVSVNTESGD ELLVSITDTDLLTKYYENDKVIHEEKLTSYPAFALDQKQQVLYYTGNNEQNEMRLFKL DLKSHKKTMLYKGAESADSLFLSKDRSTIYFRLGKADESNFRIAAFDLKTKKYKNLYP AANDQDDTVSSFFYNQKNDSFALLHYSVEEDYKKTDEANEKGIDPEPTTIHFAEGRQN KFNELKSLNQFISDIAVSDDDKRILFTSYTQKGTEQTASIQMLNADTKKYESIISNQK SFKLLIDAQPQFSKDGKNIYFLAEAKGAKKLKDETGREAKVRTIYSYSLENKTFKKVW ENPNGIINSFFVIN*" /label="ydjN CDS" gene 629404..630450 /gene="ydjN" /locus_tag="BSU_06260" /old_locus_tag="BSU06260" /label="ydjN gene" downshifts 630424 /Source="Nicolas_upshifts" /id="D305" /incds=0 /nref=41 /ntot=177 /MaxReadThrough="1.73572" /MaxDrop="4.49184" /score="21.8200083" /energy="-13.9" /TU="NA" /idTUdmin="U483" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(630484..630642) /gene="ydzJ" /locus_tag="BSU_06269" /old_locus_tag="BSU06269" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097689.1" /db_xref="EnsemblGenomes-Gn:BSU06269" /db_xref="EnsemblGenomes-Tr:CAX52576" /db_xref="GOA:O24817" /db_xref="UniProtKB/Swiss-Prot:O24817" /translation="MISNQQQKDLKKRAAFKKLNVAMNSYVELLFLSVPLIHIFKWLG SLALHLIH*" /label="ydzJ CDS" gene complement(630484..630642) /gene="ydzJ" /locus_tag="BSU_06269" /old_locus_tag="BSU06269" /label="ydzJ gene" downshifts complement(630500) /Source="Nicolas_upshifts" /id="D306" /incds=0 /nref=23 /ntot=155 /MaxReadThrough="0.7906" /MaxDrop="3.61386" /score="9.10659473" /energy="-10.1" /TU="NA" /idTUdmin="U487" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(630699..630831) /Source="Nicolas_S_feature" /locus_tag="new_681122_681254_c" /HighExp="LoTm, S8, S5, S6, S4, B36, S7, Cold, B60, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF, SigWXY" /TUshortPSig="0.994, 1, 1" /TUlongSig="SigK" /TUlongPSig="0.994" /label="S226" downshifts complement(630742) /Source="Nicolas_upshifts" /id="D307" /incds=0 /nref=57 /ntot=272 /MaxReadThrough="3.03092" /MaxDrop="6.46708" /score="5.41743429" /energy="-8.4" /TU="U484,U486,U487" /idTUdmin="U484" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(630832..631041) /gene="ydjO" /locus_tag="BSU_06270" /old_locus_tag="BSU06270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 28197687" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388508.1" /db_xref="EnsemblGenomes-Gn:BSU06270" /db_xref="EnsemblGenomes-Tr:CAB12446" /db_xref="InterPro:IPR025916" /db_xref="SubtiList:BG12805" /db_xref="UniProtKB/Swiss-Prot:O34759" /translation="MSYYNKRNQEPLPKEDVSTWECTKEDCNGWTRKNFASSDTPLCP LCGSKMVDGIRSLVNLQNNSQTKTS*" /label="ydjO CDS" gene complement(630832..631041) /gene="ydjO" /locus_tag="BSU_06270" /old_locus_tag="BSU06270" /label="ydjO gene" promotor_-10 complement(631074..631093) /Source="Nicolas_upshift_promotors" /id="U484" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.66033966033966" /psig="0.994005994005994" /xcortree=586 /SigmaFactorBS="tggggttattggaaagtcataaagaaaaaggaattAggagat tagggaaaagTATGAGACAATAGGAAATGTgcagtaaaatacatgagggaagaagtga c" /listShort="ydjO, S226" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(631085) /Source="Nicolas_upshifts" /id="U484" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.66033966033966" /psig="0.994005994005994" /xcortree=586 /SigmaFactorBS="tggggttattggaaagtcataaagaaaaaggaattAggagat tagggaaaagTATGAGACAATAGGAAATGTgcagtaaaatacatgagggaagaagtga c" /listShort="ydjO, S226" /GFF_Attribute="listLong" /label="upshifts" CDS complement(631124..631939) /gene="ydjP" /locus_tag="BSU_06280" /old_locus_tag="BSU06280" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9987136; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aminoacrylate hydrolase" /protein_id="NP_388509.1" /db_xref="EnsemblGenomes-Gn:BSU06280" /db_xref="EnsemblGenomes-Tr:CAB12447" /db_xref="GOA:O34592" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12806" /db_xref="UniProtKB/Swiss-Prot:O34592" /translation="MPYIILEDQTRLYYETHGSGTPILFIHGVLMSGQFFHKQFSVLS ANYQCIRLDLRGHGESDKVLHGHTISQYARDIREFLNAMELDHVVLAGWSMGAFVVWD YLNQFGNDNIQAAVIIDQSASDYQWEGWEHGPFDFDGLKTAMHAIQTDPLPFYESFIQ NMFAEPPAETETEWMLAEILKQPAAISSTILFNQTAADYRGTLQNINVPALLCFGEDK KFFSTAAGEHLRSNIPNATLVTFPKSSHCPFLEEPDAFNSTLLSFLDGVIGKS*" /label="ydjP CDS" gene complement(631124..631939) /gene="ydjP" /locus_tag="BSU_06280" /old_locus_tag="BSU06280" /label="ydjP gene" promotor_-35 631766..631775 /Source="Nicolas_upshift_promotors" /id="U485" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1434 /SigmaFactorBS="tgggaaatggtgtggccgtgaagcactttgtcagattcGCCG TGTCCTctaagatcaagaCGAATACATTGATAATTGGCagaaagcaccgaaaattgtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 631788..631807 /Source="Nicolas_upshift_promotors" /id="U485" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1434 /SigmaFactorBS="tgggaaatggtgtggccgtgaagcactttgtcagattcGCCG TGTCCTctaagatcaagaCGAATACATTGATAATTGGCagaaagcaccgaaaattgtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 631788 /Source="Nicolas_upshifts" /id="U485" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1434 /SigmaFactorBS="tgggaaatggtgtggccgtgaagcactttgtcagattcGCCG TGTCCTctaagatcaagaCGAATACATTGATAATTGGCagaaagcaccgaaaattgtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(631952..632941) /gene="yeaA" /locus_tag="BSU_06290" /old_locus_tag="BSU06290" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388510.1" /db_xref="EnsemblGenomes-Gn:BSU06290" /db_xref="EnsemblGenomes-Tr:CAB12448" /db_xref="InterPro:IPR025062" /db_xref="SubtiList:BG12210" /db_xref="UniProtKB/Swiss-Prot:O34803" /translation="MLTHDLHEKTKHYISIYAELKTKLKWKVSHDQILMLISSAYIVN KREFDFQRFYDLSSYIKSNIGSFSTLNSHHRFTVASILDIHFQHEAKQTFQTFIDVYN EMVKLGYKRDMFTYLSALILLTGKSETTNQKEQMNMGLAVYQQMKKNHYFLTSTQNVP LAVLLGENGKGLQALQKAETCYQLLAANGFKKGQYLHQVSHILALQSEKEPEMLVSAC KQIYQSITESVKKTKDYHYPDLALLTFLEEPDIKTVLCITDELNQEKAFKWQKEMNFK IAVSLYLSEHMEKNLLMESGLYTAIETVIQAQQAAATAAIISSTAASHTHDGN*" /label="yeaA CDS" gene complement(631952..632941) /gene="yeaA" /locus_tag="BSU_06290" /old_locus_tag="BSU06290" /label="yeaA gene" promotor_-10 complement(632806..632824) /Source="Nicolas_upshift_promotors" /id="U486" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1147 /SigmaFactorBS="aattaaaatggaaagtttcacacgatcagATATTAatgctca tttcttctGCATATATTGTGAATAAAAgagagtttgattttcagcgcttttatgattt g" /listShort="ydjP, ydjO, S226" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(632814) /Source="Nicolas_upshifts" /id="U486" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1147 /SigmaFactorBS="aattaaaatggaaagtttcacacgatcagATATTAatgctca tttcttctGCATATATTGTGAATAAAAgagagtttgattttcagcgcttttatgattt g" /listShort="ydjP, ydjO, S226" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(632840..632845) /Source="Nicolas_upshift_promotors" /id="U486" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1147 /SigmaFactorBS="aattaaaatggaaagtttcacacgatcagATATTAatgctca tttcttctGCATATATTGTGAATAAAAgagagtttgattttcagcgcttttatgattt g" /listShort="ydjP, ydjO, S226" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(632963..632978) /Source="Nicolas_upshift_promotors" /id="U487" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1666 /SigmaFactorBS="aaataacccgacaaacttgcctctagcaggcaagttttttct ttaTGAAACCTTTggccctatttaTCGTATTACGTAAAAAcaacaaaaggagctgctt t" /listShort="yeaA, ydjP, ydjO, S226, ydzJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(632984) /Source="Nicolas_upshifts" /id="U487" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1666 /SigmaFactorBS="aaataacccgacaaacttgcctctagcaggcaagttttttct ttaTGAAACCTTTggccctatttaTCGTATTACGTAAAAAcaacaaaaggagctgctt t" /listShort="yeaA, ydjP, ydjO, S226, ydzJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(632990..632999) /Source="Nicolas_upshift_promotors" /id="U487" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1666 /SigmaFactorBS="aaataacccgacaaacttgcctctagcaggcaagttttttct ttaTGAAACCTTTggccctatttaTCGTATTACGTAAAAAcaacaaaaggagctgctt t" /listShort="yeaA, ydjP, ydjO, S226, ydzJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(633039..634580) /gene="cotA" /locus_tag="BSU_06300" /old_locus_tag="BSU06300" /EC_number="1.3.3.5" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11514528, 12637519, 16391148, 17242517, 18031270, 19933362, 22112278, 25259857, 27050268" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11514528, 12637519, 16391148, 17242517, 18031270, 19933362, 22112278, 25259857, 27050268; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="outer spore coat copper-dependent promiscuous laccase" /protein_id="NP_388511.1" /db_xref="EnsemblGenomes-Gn:BSU06300" /db_xref="EnsemblGenomes-Tr:CAB12449" /db_xref="GOA:P07788" /db_xref="InterPro:IPR001117" /db_xref="InterPro:IPR008972" /db_xref="InterPro:IPR011706" /db_xref="InterPro:IPR011707" /db_xref="PDB:1GSK" /db_xref="PDB:1OF0" /db_xref="PDB:1W6L" /db_xref="PDB:1W6W" /db_xref="PDB:1W8E" /db_xref="PDB:2BHF" /db_xref="PDB:2WSD" /db_xref="PDB:2X87" /db_xref="PDB:2X88" /db_xref="PDB:3ZDW" /db_xref="PDB:4A66" /db_xref="PDB:4A67" /db_xref="PDB:4A68" /db_xref="PDB:4AKO" /db_xref="PDB:4AKP" /db_xref="PDB:4AKQ" /db_xref="PDB:4Q89" /db_xref="PDB:4Q8B" /db_xref="PDB:4YVN" /db_xref="PDB:4YVU" /db_xref="SubtiList:BG10490" /db_xref="UniProtKB/Swiss-Prot:P07788" /translation="MTLEKFVDALPIPDTLKPVQQSKEKTYYEVTMEECTHQLHRDLP PTRLWGYNGLFPGPTIEVKRNENVYVKWMNNLPSTHFLPIDHTIHHSDSQHEEPEVKT VVHLHGGVTPDDSDGYPEAWFSKDFEQTGPYFKREVYHYPNQQRGAILWYHDHAMALT RLNVYAGLVGAYIIHDPKEKRLKLPSDEYDVPLLITDRTINEDGSLFYPSAPENPSPS LPNPSIVPAFCGETILVNGKVWPYLEVEPRKYRFRVINASNTRTYNLSLDNGGDFIQI GSDGGLLPRSVKLNSFSLAPAERYDIIIDFTAYEGESIILANSAGCGGDVNPETDANI MQFRVTKPLAQKDESRKPKYLASYPSVQHERIQNIRTLKLAGTQDEYGRPVLLLNNKR WHDPVTETPKVGTTEIWSIINPTRGTHPIHLHLVSFRVLDRRPFDIARYQESGELSYT GPAVPPPPSEKGWKDTIQAHAGEVLRIAATFGPYSGRYVWHCHILEHEDYDMMRPMDI TDPHK*" /label="cotA CDS" gene complement(633039..634580) /gene="cotA" /locus_tag="BSU_06300" /old_locus_tag="BSU06300" /label="cotA gene" downshifts complement(633052) /Source="Nicolas_upshifts" /id="D308" /incds=0 /nref=46 /ntot=93 /MaxReadThrough="2.97674" /MaxDrop="5.60726" /score="22.3755425" /energy="-9.1" /TU="U488" /idTUdmin="U488" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(634611..634630) /Source="Nicolas_upshift_promotors" /id="U488" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1297 /SigmaFactorBS="tcttcttcgggcgggctgcagcacgaagatttTTTGTAACCA tcacgtccttattGTCATTAACTATAGTACCAAtttggaaaatttagataaggacaga t" /listShort="cotA" /listLong="yeaA, ydjP, ydjO, S226" /label="promotor_-10" upshifts complement(634625) /Source="Nicolas_upshifts" /id="U488" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1297 /SigmaFactorBS="tcttcttcgggcgggctgcagcacgaagatttTTTGTAACCA tcacgtccttattGTCATTAACTATAGTACCAAtttggaaaatttagataaggacaga t" /listShort="cotA" /listLong="yeaA, ydjP, ydjO, S226" /label="upshifts" promotor_-35 complement(634644..634653) /Source="Nicolas_upshift_promotors" /id="U488" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1297 /SigmaFactorBS="tcttcttcgggcgggctgcagcacgaagatttTTTGTAACCA tcacgtccttattGTCATTAACTATAGTACCAAtttggaaaatttagataaggacaga t" /listShort="cotA" /listLong="yeaA, ydjP, ydjO, S226" /label="promotor_-35" CDS complement(634732..636141) /gene="gabP" /locus_tag="BSU_06310" /old_locus_tag="BSU06310" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15849754, 16547045, 16850406, 8951816, 9677314, 24142252" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16547045, 16850406, 8951816, 9677314, 24142252; Product type t : transporter" /codon_start=1 /transl_table=11 /product="gamma-aminobutyrate (GABA) permease; proline permease" /protein_id="NP_388512.2" /db_xref="EnsemblGenomes-Gn:BSU06310" /db_xref="EnsemblGenomes-Tr:CAB12450" /db_xref="GOA:P46349" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="InterPro:IPR011265" /db_xref="SubtiList:BG11328" /db_xref="UniProtKB/Swiss-Prot:P46349" /translation="MNQSQSGLKKELKTRHMTMISIAGVIGAGLFVGSGSVIHSTGPG AVVSYALAGLLVIFIMRMLGEMSAVNPTSGSFSQYAHDAIGPWAGFTIGWLYWFFWVI VIAIEAIAGAGIIQYWFHDIPLWLTSLILTIVLTLTNVYSVKSFGEFEYWFSLIKVVT IIAFLIVGFAFIFGFAPGSEPVGFSNLTGKGGFFPEGISSVLLGIVVVIFSFMGTEIV AIAAGETSNPIESVTKATRSVVWRIIVFYVGSIAIVVALLPWNSANILESPFVAVLEH IGVPAAAQIMNFIVLTAVLSCLNSGLYTTSRMLYSLAERNEAPRRFMKLSKKGVPVQA IVAGTFFSYIAVVMNYFSPDTVFLFLVNSSGAIALLVYLVIAVSQLKMRKKLEKTNPE ALKIKMWLFPFLTYLTIIAICGILVSMAFIDSMRDELLLTGVITGIVLISYLVFRKRK VSEKAAANPVTQQQPDILP*" /label="gabP CDS" gene complement(634732..636141) /gene="gabP" /locus_tag="BSU_06310" /old_locus_tag="BSU06310" /label="gabP gene" downshifts complement(634746) /Source="Nicolas_upshifts" /id="D309" /incds=0 /nref=124 /ntot=216 /MaxReadThrough="3.22899" /MaxDrop="5.0359" /score="18.985683" /energy="-13.5" /TU="U489" /idTUdmin="U489" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" CDS complement(636179..636466) /gene="ydzX" /locus_tag="BSU_06319" /old_locus_tag="BSU06319" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097690.1" /db_xref="EnsemblGenomes-Gn:BSU06319" /db_xref="EnsemblGenomes-Tr:CAX52577" /db_xref="UniProtKB/Swiss-Prot:C0H3X2" /translation="MIHPPQKNSDEGTLFLSSNLFAPPKIPSNPRTPVLLAFYRIVNI TQNHTANKKRNIFSTHSLKAQTKHYKFEISWYIFLHEFSTNCIFMIEFQLS*" /label="ydzX CDS" gene complement(636179..636466) /gene="ydzX" /locus_tag="BSU_06319" /old_locus_tag="BSU06319" /label="ydzX gene" misc_feature complement(636182..636201) /Source="Nicolas_upshift_promotors" /id="U489" /multdbtbs="SigA,SigA" /comp="M14" /sig="SigA" /pcomp="0.447552447552448" /psig="0.996003996003996" /xcortree=2898 /SigmaFactorBS="tttgaaataagctggtatattttcttacacgaattttcgaca aactgtatatttaTGATAGAGTTTCAATTATCAtaatattcagtaatgattgcatttt a" /listShort="gabP" /listLong="cotA" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(636196) /Source="Nicolas_upshifts" /id="U489" /multdbtbs="SigA,SigA" /comp="M14" /sig="SigA" /pcomp="0.447552447552448" /psig="0.996003996003996" /xcortree=2898 /SigmaFactorBS="tttgaaataagctggtatattttcttacacgaattttcgaca aactgtatatttaTGATAGAGTTTCAATTATCAtaatattcagtaatgattgcatttt a" /listShort="gabP" /listLong="cotA" /label="upshifts" promotor_-35 636472..636479 /Source="Nicolas_upshift_promotors" /id="U490" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.748251748251748" /psig="0.999000999001" /xcortree=1749 /SigmaFactorBS="cgtcactatttttctgtggcgggtgaatcatgtttcTGTAGA CCcactgcggatcagctTTGTAAGATAATAATAGGAAaatgtgagcgagaggaggttt t" /listShort="yeaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 636495..636514 /Source="Nicolas_upshift_promotors" /id="U490" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.748251748251748" /psig="0.999000999001" /xcortree=1749 /SigmaFactorBS="cgtcactatttttctgtggcgggtgaatcatgtttcTGTAGA CCcactgcggatcagctTTGTAAGATAATAATAGGAAaatgtgagcgagaggaggttt t" /listShort="yeaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 636496 /Source="Nicolas_upshifts" /id="U490" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.748251748251748" /psig="0.999000999001" /xcortree=1749 /SigmaFactorBS="cgtcactatttttctgtggcgggtgaatcatgtttcTGTAGA CCcactgcggatcagctTTGTAAGATAATAATAGGAAaatgtgagcgagaggaggttt t" /listShort="yeaB" /GFF_Attribute="listLong" /label="upshifts" CDS 636539..637411 /gene="mneS" /locus_tag="BSU_06320" /old_locus_tag="BSU06320" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:27748968" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 27748968; Product type t: transporter" /codon_start=1 /transl_table=11 /product="secondary Mn(II) exporter, promiscuous" /protein_id="NP_388513.1" /db_xref="EnsemblGenomes-Gn:BSU06320" /db_xref="EnsemblGenomes-Tr:CAB12451" /db_xref="GOA:P46348" /db_xref="InterPro:IPR002524" /db_xref="InterPro:IPR027469" /db_xref="InterPro:IPR027470" /db_xref="InterPro:IPR036837" /db_xref="SubtiList:BG11329" /db_xref="UniProtKB/Swiss-Prot:P46348" /translation="MERYDELKKGESGALVSIAAYLVLSAIKLIIGYLFHSEALTADG LNNTTDIIASVAVLIGLRISQKPPDEDHPYGHFRAETIASLIASFIMMVVGLQVLFSA GESIFSAKQETPDMIAAWTAAGGAVLMLIVYRYNKRLAKKVKSQALLAAAADNKSDAF VSIGTFIGIVAAQFHLAWIDTVTAFVIGLLICKTAWDIFKESSHSLTDGFDIKDISAY KQTIEKISGVSRLKDIKARYLGSTVHVDVVVEVSADLNITESHDIANEIERRMKEEHA IDYSHVHMEPLEQK*" /label="mneS CDS" gene 636539..637411 /gene="mneS" /locus_tag="BSU_06320" /old_locus_tag="BSU06320" /label="mneS gene" downshifts 637376 /Source="Nicolas_upshifts" /id="D310" /incds=0 /nref=2 /ntot=88 /MaxReadThrough="1.72291" /MaxDrop="2.86431" /score="24.8167732" /energy="-10.2" /TU="U490" /idTUdmin="U490" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" downshifts complement(637651) /Source="Nicolas_upshifts" /id="D311" /incds=0 /nref=1 /ntot=3 /MaxReadThrough="0.65827" /MaxDrop="3.33542" /score="-0.424989042" /energy="-12.9" /TU="NA" /idTUdmin="U489" /TUdmin="-3015" /isTUend="FALSE" /label="downshifts" misc_feature 637705..637724 /Source="Nicolas_upshift_promotors" /id="U491" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=2248 /SigmaFactorBS="ctttattggtaacaatttgctagaatcgtttttttatacaga ttgcttttTGTGGTAAAGTTAGGTTACAttatgatgaattttgtagatgactaggagg a" /listShort="yeaC, yeaD, yebA" /listLong="S227, guaA" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 637715 /Source="Nicolas_upshifts" /id="U491" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=2248 /SigmaFactorBS="ctttattggtaacaatttgctagaatcgtttttttatacaga ttgcttttTGTGGTAAAGTTAGGTTACAttatgatgaattttgtagatgactaggagg a" /listShort="yeaC, yeaD, yebA" /listLong="S227, guaA" /label="upshifts" CDS 637761..638723 /gene="yeaC" /locus_tag="BSU_06330" /old_locus_tag="BSU06330" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 21907250, 26933057; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative MoxR-like ATPase" /protein_id="NP_388514.2" /db_xref="EnsemblGenomes-Gn:BSU06330" /db_xref="EnsemblGenomes-Tr:CAB12452" /db_xref="GOA:P94474" /db_xref="InterPro:IPR011703" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12211" /db_xref="UniProtKB/Swiss-Prot:P94474" /translation="MAYQEDLHPLLGKAVEHINRVMVGKRDIAILSLAALLAKGHVLL EDVPGVGKTMMVRALAKSIGADFKRIQFTPDLLPSDVTGVSIYNAKTMEFEYRPGPIM GNIVLADEINRTSPKTQSALLEAMEEGSVTVDGHTMQLADPFFVMATQNPVEYEGTYP LPEAQLDRFLFKLRMGYPSFNEELDVLSLQEKSHPIETLEPVIAKEDFIFLQREVQNV RADDSIKEYIVEIVQKTRQHPSVQLGVSPRGSIALMKAAQAYALLHHRDYVIPDDIQY LAPFTLPHRMMLHPEAKFEGIQAEAIVREIMSAVKVPVQRSAVR*" /label="yeaC CDS" gene 637761..638723 /gene="yeaC" /locus_tag="BSU_06330" /old_locus_tag="BSU06330" /label="yeaC gene" CDS 638723..639919 /gene="yeaD" /locus_tag="BSU_06340" /old_locus_tag="BSU06340" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388515.2" /db_xref="EnsemblGenomes-Gn:BSU06340" /db_xref="EnsemblGenomes-Tr:CAB12453" /db_xref="InterPro:IPR002881" /db_xref="InterPro:IPR036465" /db_xref="SubtiList:BG12212" /db_xref="UniProtKB/Swiss-Prot:P94475" /translation="MNKKWQWLVYGWKLIILTLLTAAVFSYAMFQGGFVSWFLFYAFL PFVLYAGLLALYPLRSFQASRQMDKTQLHAGDRLGVTVTLRRKLPFPLMYMVIEDCLP EGIESLNRDGAAAKRLVFPWFKRSMTMSYELARVPRGEHHFHSVRVRTGDVLGLIEKT AFFELDDTLFVYPFYQRFSYQVNERHQEDGVSGSSPIHQHHSSVAASVRNYQPGDRFA ALDWKTSARRSQLMTKEFEPSRSKNLFLLMDRFSSDAFEEVVSVTASILHSVLKNGAG AGLASIGKEKNIFPIQEGDQHFKHMLRHLAIAHCDAADPISRYAREELGKPSVRQADQ VVVTGQLTEDMLHLAEIGGGRVTVILAKEKDAELSQAENVMIERMMKRQIRVRIMRGG RVSRVV*" /label="yeaD CDS" gene 638723..639919 /gene="yeaD" /locus_tag="BSU_06340" /old_locus_tag="BSU06340" /label="yeaD gene" CDS 639941..642154 /gene="yebA" /locus_tag="BSU_06350" /old_locus_tag="BSU06350" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388516.2" /db_xref="EnsemblGenomes-Gn:BSU06350" /db_xref="EnsemblGenomes-Tr:CAB12454" /db_xref="GOA:P94476" /db_xref="InterPro:IPR002931" /db_xref="InterPro:IPR025403" /db_xref="InterPro:IPR036985" /db_xref="SubtiList:BG12213" /db_xref="UniProtKB/Swiss-Prot:P94476" /translation="MPHDDHKGSRLSLLLFYFLAFLLLWEWLRPLDSFTETKHTGFFS VFIGLTFLLTFFRMRWFVTVPFCVIFTLISIHILFYQGSIFDLSWVSSFLQDVYLNIT LIQSGQWNDMIPSFRTLLFFVLLWLLVYLLHYWVIYQRRILFFFLMTVAYITILDTFT PYDATFAVIRIVLIGFFMLGLLYLERIKLMERITLPKTSVLKWFLPLSVLVLAATGFG LAAPKSEPAWPDPVPFLKKITHQDRVSAGESKIGYGNHDESLGGPFQQDATPVFTWQG KERTYFRVETKDTYTGKGWIETDTGMSYQLSNGKVENLWFDHKVATERRTVRVKVDKH YGYNHLMYPIGAETIQPKQAVSLEMNGNTEQISPISEQAGEIRNMGNYTVTYNSPVYK LDELRKVKVRKNSEEYTFSDRYMQLPDSLPERVRTLAIKLTQDHDNMFDKVKAVEDYL GSNAFTYETENVTIPKNDEDYVDQFLFETKMGYCDNFSSAMVVLLRSAGIPARWVKGY TSGEYKEAGNKNGSIYEVTNNNAHSWVEVYFPEQGWVTFEPTKGFTNPAQFTSSDTKD SGSDSSSSPKKAKEKQKEEKKQPQKEEKQKEKREPAVSKKPSASHTNAGAGLYAALAV LAVLLVAAVLLYVFRSLWIPVFAVRKLKRRSDQHAFFEAYGALLKQLKRKGLPKRDSE TLRDYAKRIDEKYDIEDMSKLTLSYERALYRNEDSSALWNDSRELWENLIKRRWS*" /label="yebA CDS" gene 639941..642154 /gene="yebA" /locus_tag="BSU_06350" /old_locus_tag="BSU06350" /label="yebA gene" promotor_-35 642149..642156 /Source="Nicolas_upshift_promotors" /id="U492" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.912087912087912" /psig="0.999000999001" /xcortree=2555 /SigmaFactorBS="aaatttaattaaaagaagatggTCTTGACCgcttatcgacgt gtTGTTAGAATTAGTGAATATTatcggagtctgggagcgagttggcctgactccggca a" /listShort="S227, guaA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 642171..642190 /Source="Nicolas_upshift_promotors" /id="U492" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.912087912087912" /psig="0.999000999001" /xcortree=2555 /SigmaFactorBS="aaatttaattaaaagaagatggTCTTGACCgcttatcgacgt gtTGTTAGAATTAGTGAATATTatcggagtctgggagcgagttggcctgactccggca a" /listShort="S227, guaA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 642187..642316 /Source="Nicolas_S_feature" /locus_tag="new_692610_692739" /HighExp="G180, Oxctl, G135, LBGexp, G150, Paraq, C30, LPh, MG 25, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.63292099999999996" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigA" /TUlongPSig=1 /label="S227" upshifts 642187 /Source="Nicolas_upshifts" /id="U492" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.912087912087912" /psig="0.999000999001" /xcortree=2555 /SigmaFactorBS="aaatttaattaaaagaagatggTCTTGACCgcttatcgacgt gtTGTTAGAATTAGTGAATATTatcggagtctgggagcgagttggcctgactccggca a" /listShort="S227, guaA" /GFF_Attribute="listLong" /label="upshifts" CDS 642317..643858 /gene="guaA" /locus_tag="BSU_06360" /old_locus_tag="BSU06360" /EC_number="6.3.5.2" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1312531, 21856856; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="GMP synthetase" /protein_id="NP_388517.2" /db_xref="EnsemblGenomes-Gn:BSU06360" /db_xref="EnsemblGenomes-Tr:CAB12455" /db_xref="GOA:P29727" /db_xref="InterPro:IPR001674" /db_xref="InterPro:IPR004739" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR017926" /db_xref="InterPro:IPR022310" /db_xref="InterPro:IPR022955" /db_xref="InterPro:IPR025777" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG10647" /db_xref="UniProtKB/Swiss-Prot:P29727" /translation="MTKLVNEMILVLDFGSQYNQLITRRIREFGVYSELHPHTLTAEE IKKMNPKGIILSGGPNSVYDENSFRCDEKIFELDIPVLGICYGMQLMTHYLGGKVEAA SQREYGKANIRIEGTPDLFRDLPNEQVVWMSHGDLVVEVPEGFTVDATSHHCPNSAMS KADKKWYGVQFHPEVRHSEYGNDLLKNFVFGVCECEGEWSMENFIEIEMQKIRETVGD KQVLCALSGGVDSSVVAVLIHKAIGDQLTCIFVDHGLLRKGEAEGVMKTFSEGFNMNV IKVDAKDRFLNKLKGVSDPEQKRKIIGNEFIYVFDDEADKLKGIDYLAQGTLYTDIIE SGTATAQTIKSHHNVGGLPEDMQFELIEPLNTLFKDEVRALGTELGIPDEIVWRQPFP GPGLGIRVLGEVTEEKLEIVRESDAILREEIANHGLERDIWQYFTVLPDIRSVGVMGD ARTYDYTIGIRAVTSIDGMTSDWARIPWDVLEVISTRIVNEVKHINRVVYDITSKPPA TIEWE*" /label="guaA CDS" gene 642317..643858 /gene="guaA" /locus_tag="BSU_06360" /old_locus_tag="BSU06360" /label="guaA gene" downshifts 643844 /Source="Nicolas_upshifts" /id="D312" /incds=0 /nref=247 /ntot=268 /MaxReadThrough="2.12151" /MaxDrop="7.3702" /score="22.5795134" /energy="-18.5" /TU="NA" /idTUdmin="U492" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 643965..643969 /Source="Nicolas_upshift_promotors" /id="U493" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.767232767232767" /psig=1 /xcortree=2631 /SigmaFactorBS="cgattttgcgcgactattgttcgctttttgTATTGttttttc aaaatgaaCTTGGTACAATAGACACAGAaatcaaataagatgaattcgtataatcgcg g" /listShort="NA, pbuG" /listLong="S228, yebC" /label="promotor_-35" promotor_-10 643985..644004 /Source="Nicolas_upshift_promotors" /id="U493" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.767232767232767" /psig=1 /xcortree=2631 /SigmaFactorBS="cgattttgcgcgactattgttcgctttttgTATTGttttttc aaaatgaaCTTGGTACAATAGACACAGAaatcaaataagatgaattcgtataatcgcg g" /listShort="NA, pbuG" /listLong="S228, yebC" /label="promotor_-10" upshifts 643995 /Source="Nicolas_upshifts" /id="U493" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.767232767232767" /psig=1 /xcortree=2631 /SigmaFactorBS="cgattttgcgcgactattgttcgctttttgTATTGttttttc aaaatgaaCTTGGTACAATAGACACAGAaatcaaataagatgaattcgtataatcgcg g" /listShort="NA, pbuG" /listLong="S228, yebC" /label="upshifts" misc_RNA 644002..644104 /gene="gswC" /locus_tag="BSU_misc_RNA_9" /product="guanine riboswitch" /experiment="publication(s) with functional evidences, PMID:12787499, 15549109, 18072940, 19603494, 20022916, 20200045, 20204714, 21439477, 25023436, 27941758" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12787499, 15549109, 18072940, 19603494, 20022916, 20200045, 20204714, 21439477, 25023436, 27941758; Product type n: RNA" /label="gswC RNA" gene 644002..644104 /gene="gswC" /locus_tag="BSU_misc_RNA_9" /label="gswC gene" downshifts 644130 /Source="Nicolas_upshifts" /id="D313" /incds=0 /nref=11 /ntot=56 /MaxReadThrough="8.01916" /MaxDrop="4.7859" /score="24.3821572" /energy="-11.3" /TU="U493" /idTUdmin="U492" /TUdmin=286 /isTUend="FALSE" /label="downshifts" CDS 644239..645561 /gene="pbuG" /locus_tag="BSU_06370" /old_locus_tag="BSU06370" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:3110131, 11591660, 12923093, 15849754, 16850406, 19446032" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3110131, 11591660, 12923093, 15849754, 16850406, 19446032; Product type t : transporter" /codon_start=1 /transl_table=11 /product="hypoxanthine/guanine permease" /protein_id="NP_388518.1" /db_xref="EnsemblGenomes-Gn:BSU06370" /db_xref="EnsemblGenomes-Tr:CAB12456" /db_xref="GOA:O34987" /db_xref="InterPro:IPR006043" /db_xref="InterPro:IPR026033" /db_xref="SubtiList:BG12811" /db_xref="UniProtKB/Swiss-Prot:O34987" /translation="MKTFFQFDELGTSYRNEIIGGLTTFLSMAYILFVNPITLALESV KDFPEALRIDQGAVFTATALASAAGCILMGLIARYPIAIAPGMGLNAFFAFSVVLGMG ISWQAALSGVFISGLIFVALSLTGFREKIINAIPPELKLAVGAGIGLFITFVGLQGSG IITANPSTLVTIGNIHSGPVLLTIFGVIVTVILMVLRVNAGVFIGMLLTAVAGMIFGL VPVPTQIIGSVPSLAPTFGQAWIHLPDIFSVQMLIVILTFLFVGFFDTAGTLVAVATQ AGLMKENKLPRAGRALLADSSSIVIGAVLGTSTTTSYVESSSGVAAGARSGFAAIVTG ILFLLATFFSPLLSVVTSNVTAPALIIVGALMVAPLGKIAWDKFEVAVPAFLTMIMMP LTYSIATGIAIGFIFYPITMVCKGKAKEVHPIMYGLFVVFILYFIFLK*" /label="pbuG CDS" gene 644239..645561 /gene="pbuG" /locus_tag="BSU_06370" /old_locus_tag="BSU06370" /label="pbuG gene" downshifts 645539 /Source="Nicolas_upshifts" /id="D314" /incds=0 /nref=47 /ntot=153 /MaxReadThrough="4.18958" /MaxDrop="4.86237" /score="42.0241443" /energy="-13.4" /TU="U493" /idTUdmin="U493" /TUdmin="-86" /isTUend="FALSE" /label="downshifts" downshifts 645582 /Source="Nicolas_upshifts" /id="D315" /incds=0 /nref=1 /ntot=29 /MaxReadThrough="3.09696" /MaxDrop="3.87785" /score="42.0241443" /energy="-13.4" /TU="U493" /idTUdmin="U493" /TUdmin="-43" /isTUend="FALSE" /label="downshifts" promotor_-35 645611..645620 /Source="Nicolas_upshift_promotors" /id="U494" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1642 /SigmaFactorBS="aaccagctgcactggcagctggtttttttgttgcaaaagaTA AAACCATTtcatacgatataCCGTCATGTAGATGTGccgccatgctttacttaaatgg a" /listShort="S228, yebC" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 645631..645771 /Source="Nicolas_S_feature" /locus_tag="new_696054_696194" /HighExp="T1.30H, T1.0H, T2.0H, T0.30H, B60, T2.30H, T-0.40H, T0.0H, T3.0H, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.998" /TUlongSig="SigA" /TUlongPSig=1 /label="S228" upshifts 645631 /Source="Nicolas_upshifts" /id="U494" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1642 /SigmaFactorBS="aaccagctgcactggcagctggtttttttgttgcaaaagaTA AAACCATTtcatacgatataCCGTCATGTAGATGTGccgccatgctttacttaaatgg a" /listShort="S228, yebC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 645633..645648 /Source="Nicolas_upshift_promotors" /id="U494" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1642 /SigmaFactorBS="aaccagctgcactggcagctggtttttttgttgcaaaagaTA AAACCATTtcatacgatataCCGTCATGTAGATGTGccgccatgctttacttaaatgg a" /listShort="S228, yebC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 645772..646575 /gene="yebC" /locus_tag="BSU_06380" /old_locus_tag="BSU06380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388519.2" /db_xref="EnsemblGenomes-Gn:BSU06380" /db_xref="EnsemblGenomes-Tr:CAB12457" /db_xref="GOA:O34341" /db_xref="SubtiList:BG12812" /db_xref="UniProtKB/Swiss-Prot:O34341" /translation="MTEERKETFEEEINQSERIDADEEPLSRMSRKASRQSKQKQKQK QKPRQERGESTVKDKLASVWAAINRYCGFAFSILKSPAKTVVTDGFSHYKYGLISMLI FSIIFSIGNWFQLKASWNRPLGFGERHHAFYDGFLVVLVYLLIFFAVMVFAIWAVSRY MMKQKVTFREAAAVLGSLLVPVIAVSILWLIFAIVNIPMLTVLFTVLILFSIFFIIAL YVQRVYQAAQDAPIDYIYCVFAVVAIALLFTAVTWPFISEYITASLIPL*" /label="yebC CDS" gene 645772..646575 /gene="yebC" /locus_tag="BSU_06380" /old_locus_tag="BSU06380" /label="yebC gene" downshifts 646560 /Source="Nicolas_upshifts" /id="D316" /incds=0 /nref=218 /ntot=263 /MaxReadThrough="1.47691" /MaxDrop="7.03926" /score="33.0377004" /energy="-10.7" /TU="NA" /idTUdmin="U494" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 646643..646650 /Source="Nicolas_upshift_promotors" /id="U495" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig=1 /xcortree=527 /SigmaFactorBS="tgtcacactttttacaaatatatctaaaaaacaTAGTTGATt tgtaggattaacCCGTGTATGATGGGGAAAATgctgaaaacgtccagcgcaaaaacct t" /listShort="S229, yebD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 646664..646683 /Source="Nicolas_upshift_promotors" /id="U495" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig=1 /xcortree=527 /SigmaFactorBS="tgtcacactttttacaaatatatctaaaaaacaTAGTTGATt tgtaggattaacCCGTGTATGATGGGGAAAATgctgaaaacgtccagcgcaaaaacct t" /listShort="S229, yebD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 646670..646733 /Source="Nicolas_S_feature" /locus_tag="new_697093_697156" /HighExp="B60, S2, S7, S8, Lbstat, nit, S4, BC, BT, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S229" upshifts 646670 /Source="Nicolas_upshifts" /id="U495" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig=1 /xcortree=527 /SigmaFactorBS="tgtcacactttttacaaatatatctaaaaaacaTAGTTGATt tgtaggattaacCCGTGTATGATGGGGAAAATgctgaaaacgtccagcgcaaaaacct t" /listShort="S229, yebD" /GFF_Attribute="listLong" /label="upshifts" CDS 646734..646901 /gene="yebD" /locus_tag="BSU_06390" /old_locus_tag="BSU06390" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_388520.3" /db_xref="EnsemblGenomes-Gn:BSU06390" /db_xref="EnsemblGenomes-Tr:CAB12458" /db_xref="InterPro:IPR025072" /db_xref="SubtiList:BG12813" /db_xref="UniProtKB/Swiss-Prot:O34904" /translation="MADVLRRAINQKKQFLKTKLLLSEFYQGRGEQLADYTLSELEKE YKSLQKMKKEI*" /label="yebD CDS" gene 646734..646901 /gene="yebD" /locus_tag="BSU_06390" /old_locus_tag="BSU06390" /label="yebD gene" downshifts 646908 /Source="Nicolas_upshifts" /id="D317" /incds=0 /nref=64 /ntot=163 /MaxReadThrough="2.85884" /MaxDrop="5.66286" /score="29.2645456" /energy="-9" /TU="NA" /idTUdmin="U495" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-35 646952..646958 /Source="Nicolas_upshift_promotors" /id="U496" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=744 /SigmaFactorBS="aggtgagtctgctgaaaagcgggcttttttgttttgATTTTG AaaaggcgagaaagaGGGTAAACTACTACTGTTCaacacataaaagcgtgtcgaaata t" /listShort="S230, yebE, yebG, NA, S231" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 646973..646991 /Source="Nicolas_upshift_promotors" /id="U496" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=744 /SigmaFactorBS="aggtgagtctgctgaaaagcgggcttttttgttttgATTTTG AaaaggcgagaaagaGGGTAAACTACTACTGTTCaacacataaaagcgtgtcgaaata t" /listShort="S230, yebE, yebG, NA, S231" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 646976..647062 /Source="Nicolas_S_feature" /locus_tag="new_697399_697485" /HighExp="Etha, Gly, M9-stat, Sw, B60, S4, S6, LPhT, S3, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.966" /TUlongSig="NA" /TUlongPSig="NA" /label="S230" upshifts 646976 /Source="Nicolas_upshifts" /id="U496" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=744 /SigmaFactorBS="aggtgagtctgctgaaaagcgggcttttttgttttgATTTTG AaaaggcgagaaagaGGGTAAACTACTACTGTTCaacacataaaagcgtgtcgaaata t" /listShort="S230, yebE, yebG, NA, S231" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 647041..647048 /Source="Nicolas_upshift_promotors" /id="U497" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.876123876123876" /psig="0.999000999001" /xcortree=2463 /SigmaFactorBS="cgtgtcgaaatattttgcttaagcttacgggcgaagcTGATT GTAaacggctcatttcTCTAGTAGAATATGAATGCTttgtgcaagctgaagagtaggg g" /listShort="yebE, yebG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 647062..647081 /Source="Nicolas_upshift_promotors" /id="U497" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.876123876123876" /psig="0.999000999001" /xcortree=2463 /SigmaFactorBS="cgtgtcgaaatattttgcttaagcttacgggcgaagcTGATT GTAaacggctcatttcTCTAGTAGAATATGAATGCTttgtgcaagctgaagagtaggg g" /listShort="yebE, yebG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 647064 /Source="Nicolas_upshifts" /id="U497" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.876123876123876" /psig="0.999000999001" /xcortree=2463 /SigmaFactorBS="cgtgtcgaaatattttgcttaagcttacgggcgaagcTGATT GTAaacggctcatttcTCTAGTAGAATATGAATGCTttgtgcaagctgaagagtaggg g" /listShort="yebE, yebG" /GFF_Attribute="listLong" /label="upshifts" CDS 647115..647669 /gene="yebE" /locus_tag="BSU_06400" /old_locus_tag="BSU06400" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388521.2" /db_xref="EnsemblGenomes-Gn:BSU06400" /db_xref="EnsemblGenomes-Tr:CAB12459" /db_xref="GOA:O34624" /db_xref="InterPro:IPR019264" /db_xref="InterPro:IPR022930" /db_xref="SubtiList:BG12814" /db_xref="UniProtKB/Swiss-Prot:O34624" /translation="MMQTILSNGIAMVLIILIINIVYVSFFTIRMILTLKGQRYLAAG ISTIEILVYVTGLSLVLDNLDQIQNVIAYALGYGLGVIVGMKIEEKLALGYIMVNVIT KELDLDLPKQLREKGYGVTNWVAGGLEGDRTALQILTPRRYELQLYDTIKTLDSKAFI IAYEPKTIHGGFWVKAVKKRRIKE*" /label="yebE CDS" gene 647115..647669 /gene="yebE" /locus_tag="BSU_06400" /old_locus_tag="BSU06400" /label="yebE gene" CDS 647669..647866 /gene="yebG" /locus_tag="BSU_06410" /old_locus_tag="BSU06410" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388523.1" /db_xref="EnsemblGenomes-Gn:BSU06410" /db_xref="EnsemblGenomes-Tr:CAB12461" /db_xref="InterPro:IPR025930" /db_xref="SubtiList:BG12816" /db_xref="UniProtKB/Swiss-Prot:O34700" /translation="MAKPKKKKFEVTEQQTIDAVLQQMKEEGYLPVRRMEEPIFMEKK ENGSIQIVPCGKKIVFEGKLI*" /label="yebG CDS" gene 647669..647866 /gene="yebG" /locus_tag="BSU_06410" /old_locus_tag="BSU06410" /label="yebG gene" downshifts 647856 /Source="Nicolas_upshifts" /id="D318" /incds=0 /nref=2 /ntot=91 /MaxReadThrough="2.80904" /MaxDrop="2.65424" /score="17.462689" /energy="-17.6" /TU="U496" /idTUdmin="U497" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 647912..647919 /Source="Nicolas_upshift_promotors" /id="U498" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2428 /SigmaFactorBS="attagtagaatgaatttttgtatcgttcgataatatCGTTGA CAttatccatgtccgtTGTTAAGATAAACATGAAATcaaaacacgacctcatataatc t" /listShort="NA, S231, purE, purK, purB, purC, purS, purQ, purL, purF, S232, purM, purN, purH, purD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 647934..647953 /Source="Nicolas_upshift_promotors" /id="U498" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2428 /SigmaFactorBS="attagtagaatgaatttttgtatcgttcgataatatCGTTGA CAttatccatgtccgtTGTTAAGATAAACATGAAATcaaaacacgacctcatataatc t" /listShort="NA, S231, purE, purK, purB, purC, purS, purQ, purL, purF, S232, purM, purN, purH, purD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 647936 /Source="Nicolas_upshifts" /id="U498" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2428 /SigmaFactorBS="attagtagaatgaatttttgtatcgttcgataatatCGTTGA CAttatccatgtccgtTGTTAAGATAAACATGAAATcaaaacacgacctcatataatc t" /listShort="NA, S231, purE, purK, purB, purC, purS, purQ, purL, purF, S232, purM, purN, purH, purD" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 647946..648048 /gene="gswD" /locus_tag="BSU_misc_RNA_10" /product="guanine riboswitch" /experiment="publication(s) with functional evidences, PMID:12787499, 15549109, 18072940, 19603494, 20022916, 20200045, 20204714, 21439477, 25023436, 27941758" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12787499, 15549109, 18072940, 19603494, 20022916, 20200045, 20204714, 21439477, 25023436, 27941758; Product type n: RNA" /label="gswD RNA" gene 647946..648048 /gene="gswD" /locus_tag="BSU_misc_RNA_10" /label="gswD gene" S_feature 648049..648188 /Source="Nicolas_S_feature" /locus_tag="new_698472_698611" /HighExp="MG 10, MG 15, MG t5, BMM, MG 25, MG 5, HPh, GM 45, GM 90, M9-exp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="1, 0.966" /TUlongSig="NA" /TUlongPSig="NA" /label="S231" CDS 648189..648677 /gene="purE" /locus_tag="BSU_06420" /old_locus_tag="BSU06420" /EC_number="5.4.99.18" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 12787499, 16138311, 9683488; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N5-carboxyaminoimidazole ribonucleotide mutase" /protein_id="NP_388524.1" /db_xref="EnsemblGenomes-Gn:BSU06420" /db_xref="EnsemblGenomes-Tr:CAB12462" /db_xref="GOA:P12044" /db_xref="InterPro:IPR000031" /db_xref="InterPro:IPR024694" /db_xref="InterPro:IPR033747" /db_xref="InterPro:IPR035893" /db_xref="SubtiList:BG10700" /db_xref="UniProtKB/Swiss-Prot:P12044" /translation="MQPLVGIIMGSTSDWETMKHACDILDELNVPYEKKVVSAHRTPD FMFEYAETARERGIKVIIAGAGGAAHLPGMTAAKTTLPVIGVPVQSKALNGMDSLLSI VQMPGGVPVATTSIGKAGAVNAGLLAAQILSAFDEDLARKLDERRENTKQTVLESSDQ LV*" /label="purE CDS" gene 648189..648677 /gene="purE" /locus_tag="BSU_06420" /old_locus_tag="BSU06420" /label="purE gene" CDS 648670..649812 /gene="purK" /locus_tag="BSU_06430" /old_locus_tag="BSU06430" /EC_number="6.3.4.18" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 8998996, 9683488, 21931218, 25372694; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N5-carboxyaminoimidazole ribonucleotide synthase" /protein_id="NP_388525.2" /db_xref="EnsemblGenomes-Gn:BSU06430" /db_xref="EnsemblGenomes-Tr:CAB12463" /db_xref="GOA:P12045" /db_xref="InterPro:IPR003135" /db_xref="InterPro:IPR005875" /db_xref="InterPro:IPR006115" /db_xref="InterPro:IPR011054" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="SubtiList:BG10701" /db_xref="UniProtKB/Swiss-Prot:P12045" /translation="MSKQIIYPGAVIGIIGGGQLGKMMAVSAKQMGYKVAVVDPVKDS PCGQVADVEITAHYNDREAIRKLAEISDIITYEFENIDYDALHWLKDHAYLPQGSELL LITQNRETEKKAIQSAGCEVAPYSIVKTKNELKQAVQELRLPAVLKTCRGGYDGKGQF VIKEEAQMEQAAALLEHGTCILESWVSFKMELSVIVVRSVNGEISTFPTAENIHHNNI LFQSIVPARVEKGIQQKAADLAVKLADELNLVGPLAVEMFLTEDGELLVNELAPRPHN SGHYTLDLCETSQFEQHIRAVCGLPLGKTDLLKPGMMVNLLGDEVKLVEEDPELLKEA KLYIYGKHEIKKGRKMGHITFMKQPEDEWIQEITNKWMNRDGGQAE*" /label="purK CDS" gene 648670..649812 /gene="purK" /locus_tag="BSU_06430" /old_locus_tag="BSU06430" /label="purK gene" CDS 649809..651104 /gene="purB" /locus_tag="BSU_06440" /old_locus_tag="BSU06440" /EC_number="4.3.2.2" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9622500, 9683488, 9890879, 11063569, 12787499; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="adenylosuccinate lyase" /protein_id="NP_388526.1" /db_xref="EnsemblGenomes-Gn:BSU06440" /db_xref="EnsemblGenomes-Tr:CAB12464" /db_xref="GOA:P12047" /db_xref="InterPro:IPR000362" /db_xref="InterPro:IPR004769" /db_xref="InterPro:IPR008948" /db_xref="InterPro:IPR019468" /db_xref="InterPro:IPR020557" /db_xref="InterPro:IPR022761" /db_xref="InterPro:IPR024083" /db_xref="PDB:1F1O" /db_xref="SubtiList:BG10702" /db_xref="UniProtKB/Swiss-Prot:P12047" /translation="MIERYSRPEMSAIWTDENRFQAWLEVEILACEAWAELGVIPKED VKVMRENASFDINRILEIEKDTRHDVVAFTRAVSESLGEERKWVHYGLTSTDVVDTAL SYLLKQANDILLKDLERFVDIIKEKAKEHKYTVMMGRTHGVHAEPTTFGLKLALWHEE MKRNLERFKQAKAGIEVGKISGAVGTYANIDPFVEQYVCEKLGLKAAPISTQTLQRDR HADYMATLALIATSIEKFAVEIRGLQKSETREVEEFFAKGQKGSSAMPHKRNPIGSEN MTGMARVIRGYMMTAYENVPLWHERDISHSSAERIILPDATIALNYMLNRFSNIVKNL TVFPENMKRNMDRTLGLIYSQRVLLALIDTGLTREEAYDTVQPKAMEAWEKQVPFREL VEAEEKITSRLSPEKIADCFDYNYHLKNVDLIFERLGLA*" /label="purB CDS" gene 649809..651104 /gene="purB" /locus_tag="BSU_06440" /old_locus_tag="BSU06440" /label="purB gene" promotor_-10 complement(650114..650133) /Source="Nicolas_upshift_promotors" /id="U499" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.791208791208791" /psig="0.993006993006993" /xcortree=1708 /SigmaFactorBS="tttcgctttttcttttataatgtcaacaaatctctcaagaTC CTTGAGcaaaatatcgtttgCCTGTTTTAATAAGTAGGAAagagccgtatcaacaacg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(650135) /Source="Nicolas_upshifts" /id="U499" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.791208791208791" /psig="0.993006993006993" /xcortree=1708 /SigmaFactorBS="tttcgctttttcttttataatgtcaacaaatctctcaagaTC CTTGAGcaaaatatcgtttgCCTGTTTTAATAAGTAGGAAagagccgtatcaacaacg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(650148..650155) /Source="Nicolas_upshift_promotors" /id="U499" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.791208791208791" /psig="0.993006993006993" /xcortree=1708 /SigmaFactorBS="tttcgctttttcttttataatgtcaacaaatctctcaagaTC CTTGAGcaaaatatcgtttgCCTGTTTTAATAAGTAGGAAagagccgtatcaacaacg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 651178..651903 /gene="purC" /locus_tag="BSU_06450" /old_locus_tag="BSU06450" /EC_number="6.3.2.6" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 2495272, 9683488, 10784038, 12787499, 26118696; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylaminoimidazole succinocarboxamide synthetase" /protein_id="NP_388527.1" /db_xref="EnsemblGenomes-Gn:BSU06450" /db_xref="EnsemblGenomes-Tr:CAB12465" /db_xref="GOA:P12046" /db_xref="InterPro:IPR001636" /db_xref="InterPro:IPR018236" /db_xref="InterPro:IPR028923" /db_xref="InterPro:IPR033934" /db_xref="SubtiList:BG10703" /db_xref="UniProtKB/Swiss-Prot:P12046" /translation="MNIVKNELLYEGKAKKIYKTDDENTLYVVYKDSATAFNGEKKAE ISGKGRLNNEISSLIFKHLHAKGINNHFIERISETEQLIKKVTIVPLEVVVRNVVAGS MSKRLGIPEGTELEQPIIEFYYKDDALGDPLITEDHIWLLKAATPEQVETIKSITTIV NEELQSIFDDCHVRLIDFKLEFGLDAEGQVLLADEISPDTCRLWDKETNEKLDKDLFR RNLGSLTDAYEEIFNRLGGIHHV*" /label="purC CDS" gene 651178..651903 /gene="purC" /locus_tag="BSU_06450" /old_locus_tag="BSU06450" /label="purC gene" CDS 651896..652150 /gene="purS" /locus_tag="BSU_06460" /old_locus_tag="BSU06460" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10784038, 12787499" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10784038, 12787499; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor required for phosphoribosylformylglycinamidine synthetase activity" /protein_id="NP_388528.1" /db_xref="EnsemblGenomes-Gn:BSU06460" /db_xref="EnsemblGenomes-Tr:CAB12466" /db_xref="GOA:P12049" /db_xref="InterPro:IPR003850" /db_xref="InterPro:IPR036604" /db_xref="PDB:1T4A" /db_xref="PDB:1TWJ" /db_xref="SubtiList:BG10704" /db_xref="UniProtKB/Swiss-Prot:P12049" /translation="MYKVKVYVSLKESVLDPQGSAVQHALHSMTYNEVQDVRIGKYME LTIEKSDRDLDVLVKEMCEKLLANTVIEDYRYEVEEVVAQ*" /label="purS CDS" gene 651896..652150 /gene="purS" /locus_tag="BSU_06460" /old_locus_tag="BSU06460" /label="purS gene" CDS 652147..652830 /gene="purQ" /locus_tag="BSU_06470" /old_locus_tag="BSU06470" /EC_number="6.3.5.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12787499, 15301530, 15301532, 10784038, 9683488" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12787499, 15301530, 15301532, 10784038, 9683488; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylformylglycinamidine synthetase subunit I" /protein_id="NP_388529.1" /db_xref="EnsemblGenomes-Gn:BSU06470" /db_xref="EnsemblGenomes-Tr:CAB12467" /db_xref="GOA:P12041" /db_xref="InterPro:IPR010075" /db_xref="InterPro:IPR017926" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG10706" /db_xref="UniProtKB/Swiss-Prot:P12041" /translation="MKFAVIVLPGSNCDIDMYHAVKDELGHEVEYVWHEETSLDGFDG VLIPGGFSYGDYLRCGAIARFANIMPAVKQAAAEGKPVLGVCNGFQILQELGLLPGAM RRNKDLKFICRPVELIVQNDETLFTASYEKGESITIPVAHGEGNFYCDDETLATLKEN NQIAFTYGSNINGSVSDIAGVVNEKGNVLGMMPHPERAVDELLGSADGLKLFQSIVKN WRETHVTTA*" /label="purQ CDS" gene 652147..652830 /gene="purQ" /locus_tag="BSU_06470" /old_locus_tag="BSU06470" /label="purQ gene" CDS 652814..655042 /gene="purL" /locus_tag="BSU_06480" /old_locus_tag="BSU06480" /EC_number="6.3.5.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12787499, 15301532, 10784038, 9683488, 21671997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12787499, 15301532, 10784038, 9683488, 21671997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylformylglycinamidine synthetase subunit II" /protein_id="NP_388530.2" /db_xref="EnsemblGenomes-Gn:BSU06480" /db_xref="EnsemblGenomes-Tr:CAB12468" /db_xref="GOA:P12042" /db_xref="InterPro:IPR010074" /db_xref="InterPro:IPR010918" /db_xref="InterPro:IPR016188" /db_xref="InterPro:IPR036676" /db_xref="InterPro:IPR036921" /db_xref="SubtiList:BG10705" /db_xref="UniProtKB/Swiss-Prot:P12042" /translation="MSLLLEPSKEQIKEEKLYQQMGVSDDEFALIESILGRLPNYTEI GIFSVMWSEHCSYKNSKPILRKFPTSGERVLQGPGEGAGIVDIGDNQAVVFKIESHNH PSALEPYQGAATGVGGIIRDVFSMGARPIAVLNSLRFGELTSPRVKYLFEEVVAGIAG YGNCIGIPTVGGEVQFDSSYEGNPLVNAMCVGLINHEDIKKGQAKGVGNTVMYVGAKT GRDGIHGATFASEEMSDSSEEKRSAVQVGDPFMEKLLLEACLEVIQCDALVGIQDMGA AGLTSSSAEMASKAGSGIEMNLDLIPQRETGMTAYEMMLSESQERMLLVIERGREQEI IDIFDKYDLEAVSVGHVTDDKMLRLTHKGEVVCELPVDALAEEAPVYHKPSQEPAYYR EFLETDVPAPQIEDANEMLKALLQQPTIASKEWVYDQYDYMVRTNTVVAPGSDAGVLR IRGTKKALAMTTDCNARYLYLDPEVGGKIAVAEAARNIICSGAEPLAVTDNLNFGNPE KPEIFWQIEKAADGISEACNVLSTPVIGGNVSLYNESNGTAIYPTPVIGMVGLIEDTA HITTQHFKQAGDLVYVIGETKPEFAGSELQKMTEGRIYGKAPQIDLDVELSRQKALLD AIKKGFVQSAHDVSEGGLGVAIAESVMTTENLGANVTVEGEAALLFSESQSRFVVSVK KEHQAAFEATVKDAVHIGEVTADGILAIQNQDGQQMIHAQTKELERVWKGAIPCLLKS KA*" /label="purL CDS" gene 652814..655042 /gene="purL" /locus_tag="BSU_06480" /old_locus_tag="BSU06480" /label="purL gene" downshifts complement(653062) /Source="Nicolas_upshifts" /id="D319" /incds=1 /nref=1 /ntot=47 /MaxReadThrough="0.69202" /MaxDrop="3.99287" /score="-6.56256716" /energy="-16.7" /TU="NA" /idTUdmin="U499" /TUdmin="-3147" /isTUend="FALSE" /label="downshifts" CDS 655018..656448 /gene="purF" /locus_tag="BSU_06490" /old_locus_tag="BSU06490" /EC_number="2.4.2.14" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9683488, 10049369, 12787499, 16321950, 17981983" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9683488, 10049369, 12787499, 16321950, 17981983; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamine phosphoribosylpyrophosphate amidotransferase" /protein_id="NP_388531.2" /db_xref="EnsemblGenomes-Gn:BSU06490" /db_xref="EnsemblGenomes-Tr:CAB12469" /db_xref="GOA:P00497" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR005854" /db_xref="InterPro:IPR017932" /db_xref="InterPro:IPR029055" /db_xref="InterPro:IPR029057" /db_xref="InterPro:IPR035584" /db_xref="PDB:1AO0" /db_xref="PDB:1GPH" /db_xref="SubtiList:BG10707" /db_xref="UniProtKB/Swiss-Prot:P00497" /translation="MLAEIKGLNEECGVFGIWGHEEAPQITYYGLHSLQHRGQEGAGI VATDGEKLTAHKGQGLITEVFQNGELSKVKGKGAIGHVRYATAGGGGYENVQPLLFRS QNNGSLALAHNGNLVNATQLKQQLENQGSIFQTSSDTEVLAHLIKRSGHFTLKDQIKN SLSMLKGAYAFLIMTETEMIVALDPNGLRPLSIGMMGDAYVVASETCAFDVVGATYLR EVEPGEMLIINDEGMKSERFSMNINRSICSMEYIYFSRPDSNIDGINVHSARKNLGKM LAQESAVEADVVTGVPDSSISAAIGYAEATGIPYELGLIKNRYVGRTFIQPSQALREQ GVRMKLSAVRGVVEGKRVVMVDDSIVRGTTSRRIVTMLREAGATEVHVKISSPPIAHP CFYGIDTSTHEELIASSHSVEEIRQEIGADTLSFLSVEGLLKGIGRKYDDSNCGQCLA CFTGKYPTEIYQDTVLPHVKEAVLTK*" /label="purF CDS" gene 655018..656448 /gene="purF" /locus_tag="BSU_06490" /old_locus_tag="BSU06490" /label="purF gene" S_feature 656449..656549 /Source="Nicolas_S_feature" /locus_tag="new_706872_706972" /HighExp="MG 15, MG 25, MG 10, MG 5, aero, S0, MG t5, Gly, LPh, GM 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S232" CDS 656550..657590 /gene="purM" /locus_tag="BSU_06500" /old_locus_tag="BSU06500" /EC_number="6.3.3.1" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9683488, 10508786, 12787499, 16321950; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylaminoimidazole synthetase" /protein_id="NP_388532.2" /db_xref="EnsemblGenomes-Gn:BSU06500" /db_xref="EnsemblGenomes-Tr:CAB12470" /db_xref="GOA:P12043" /db_xref="InterPro:IPR004733" /db_xref="InterPro:IPR010918" /db_xref="InterPro:IPR016188" /db_xref="InterPro:IPR036676" /db_xref="InterPro:IPR036921" /db_xref="SubtiList:BG10708" /db_xref="UniProtKB/Swiss-Prot:P12043" /translation="MSEAYKNAGVDIEAGYEAVKRMKKHVERTKRLGVMGSLGGFGGM FDLSELSYQKPVLISGTDGVGTKLKLAFSMDKHDTIGVDAVAMCVNDVLAQGAEPLFF LDYLAVGKADPVKIEQIVQGVAEGCEQSGSALVGGETAEMPGLYTADEYDIAGFSVGV AEKDEIVTGEKIEEGHLLIGLSSSGLHSNGFSLVRKVLLDDAELDLDTTYEPFERPLG EELLEPTRIYVKPVLAAVKSGKIDGMAHVTGGGFIENIPRMLPEGLSAEIDHGSWPIP PIFSFLQEYGKLKEEDMFNVFNMGIGFVLAVKEEHLTDVIGTLESHGEKAYLIGRVKK GEGVTFGGAALS*" /label="purM CDS" gene 656550..657590 /gene="purM" /locus_tag="BSU_06500" /old_locus_tag="BSU06500" /label="purM gene" CDS 657587..658174 /gene="purN" /locus_tag="BSU_06510" /old_locus_tag="BSU06510" /EC_number="2.1.2.2" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9683488, 10569930, 12787499, 19574646; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylglycinamide formyltransferase" /protein_id="NP_388533.2" /db_xref="EnsemblGenomes-Gn:BSU06510" /db_xref="EnsemblGenomes-Tr:CAB12471" /db_xref="GOA:P12040" /db_xref="InterPro:IPR001555" /db_xref="InterPro:IPR002376" /db_xref="InterPro:IPR004607" /db_xref="InterPro:IPR036477" /db_xref="SubtiList:BG10709" /db_xref="UniProtKB/Swiss-Prot:P12040" /translation="MKKFAVFASGNGSNFEAIVTRLKEENWDASAALLVCDKPQAKVI ERAEAFHIPSFAFEPKSYENKAAFEQAIIEQLRLHEVELIALAGYMRLIGDTLLQAYG GKIINIHPSLLPAFPGIDAVGQAFRAGVKVAGITVHYVDEGMDTGPIIAQKAIEIDEH DTLETIEQRIHKLEHKWYPSVIKQLLGLNNRGEKA*" /label="purN CDS" gene 657587..658174 /gene="purN" /locus_tag="BSU_06510" /old_locus_tag="BSU06510" /label="purN gene" misc_feature 657597..657611 /Source="Nicolas_upshift_promotors" /id="U500" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.52947052947053" /psig="0.52947052947053" /xcortree=2706 /SigmaFactorBS="aaaaaaggtgaaggcgtcacattcggcggtgcggcactttca tgaaaaagtTTGCGGTATTTGCATcaggaaacggttcaaacttcgaagccatcgtcac g" /listShort="purN, purH, purD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 657606 /Source="Nicolas_upshifts" /id="U500" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.52947052947053" /psig="0.52947052947053" /xcortree=2706 /SigmaFactorBS="aaaaaaggtgaaggcgtcacattcggcggtgcggcactttca tgaaaaagtTTGCGGTATTTGCATcaggaaacggttcaaacttcgaagccatcgtcac g" /listShort="purN, purH, purD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(657873..657891) /Source="Nicolas_upshift_promotors" /id="U501" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1204 /SigmaFactorBS="tccaggaaacgccggaagaagcgatgggTGAATGttaatgat ttttcccCCATATGCTTGAAGGAGCGtatcaccgatcagcctcatatagccggcaaga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(657880) /Source="Nicolas_upshifts" /id="U501" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1204 /SigmaFactorBS="tccaggaaacgccggaagaagcgatgggTGAATGttaatgat ttttcccCCATATGCTTGAAGGAGCGtatcaccgatcagcctcatatagccggcaaga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(657907..657912) /Source="Nicolas_upshift_promotors" /id="U501" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1204 /SigmaFactorBS="tccaggaaacgccggaagaagcgatgggTGAATGttaatgat ttttcccCCATATGCTTGAAGGAGCGtatcaccgatcagcctcatatagccggcaaga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 658171..659709 /gene="purH" /locus_tag="BSU_06520" /old_locus_tag="BSU06520" /EC_number="2.1.2.3" /EC_number="3.5.4.10" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12787499, 1937050, 9683488; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fused phosphoribosylaminoimidazole carboxy formyl formyltransferase; inosine-monophosphate cyclohydrolase" /protein_id="NP_388534.2" /db_xref="EnsemblGenomes-Gn:BSU06520" /db_xref="EnsemblGenomes-Tr:CAB12472" /db_xref="GOA:P12048" /db_xref="InterPro:IPR002695" /db_xref="InterPro:IPR011607" /db_xref="InterPro:IPR016193" /db_xref="InterPro:IPR024051" /db_xref="InterPro:IPR036914" /db_xref="SubtiList:BG10710" /db_xref="UniProtKB/Swiss-Prot:P12048" /translation="MTIKRALISVSDKTNLVPFVKELTELGVEVISTGGTKKLLQENG VDVIGISEVTGFPEIMDGRLKTLHPNIHGGLLAVRGNEEHMAQINEHGIQPIDLVVVN LYPFKETISKEDVTYEEAIENIDIGGPGMLRAASKNHQDVTVIVDPADYSPVLNQIKE EGSVSLQKKRELAAKVFRHTAAYDALIADYLTNVVGEKEPEQFTVTFEKKQSLRYGEN PHQEATFYQTALPVKGSIAQAEQLHGKELSYNNIKDADAAVQIVREFTEPAAVAVKHM NPCGVGTGKTIAEAFDRAFEADKTSIFGGIIALNREVDKATAEALHNIFLEIIIAPSF SQEALDVLTAKKNLRLLTLDVSAAVQKEKQLTSVQGGLLIQDLDMHGFDDAEISIPTK REPNEQEWEDLKLAWKVVKHVKSNAIVLAKDNMTVGVGAGQMNRVGSAKIAIEQAGEK AKGSALGSDAYFPMPDTVEEAAKAGVTAIIQPGGSIRDEDSIKKADEYGIAMVFTGIR HFKH*" /label="purH CDS" gene 658171..659709 /gene="purH" /locus_tag="BSU_06520" /old_locus_tag="BSU06520" /label="purH gene" CDS 659725..660993 /gene="purD" /locus_tag="BSU_06530" /old_locus_tag="BSU06530" /EC_number="6.3.4.13" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9683488, 12787499, 16321950" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9683488, 12787499, 16321950; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylglycinamide synthetase" /protein_id="NP_388535.1" /db_xref="EnsemblGenomes-Gn:BSU06530" /db_xref="EnsemblGenomes-Tr:CAB12473" /db_xref="GOA:P12039" /db_xref="InterPro:IPR000115" /db_xref="InterPro:IPR011054" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="InterPro:IPR020559" /db_xref="InterPro:IPR020560" /db_xref="InterPro:IPR020561" /db_xref="InterPro:IPR020562" /db_xref="InterPro:IPR037123" /db_xref="PDB:2XCL" /db_xref="PDB:2XD4" /db_xref="SubtiList:BG10711" /db_xref="UniProtKB/Swiss-Prot:P12039" /translation="MNVLIIGKGGREHTLAWKAAQSSLVENVFAAPGNDGMAASAQLV NIEESDHAGLVSFAKQNQVGLTIVGPEVPLIEGLVDEFEKAGLHVFGPSKAAAIIEGS KQFAKDLMKKYDIPTAEYETFTSFDEAKAYVQEKGAPIVIKADGLAAGKGVTVAMTEE EAIACLHDFLEDEKFGDASASVVIEEYLSGEEFSLMAFVKGEKVYPMVIAQDHKRAFD GDKGPNTGGMGAYSPVPQISEETVRHAVETIVKPAAKAMVQEGRSFTGVLYAGLMLTE NGSKVIEFNARFGDPETQVVLPRMESDLVQVLLDLLDDKEVDLRWKDTAAVSVVLASE GYPESYAKGTPIGSLAAETEQVVVFHAGTKAEGGEFVTNGGRVANVTAFDETFEAARD RVYKAVDEIFKPGLFFRKDIGARALKAAQK*" /label="purD CDS" gene 659725..660993 /gene="purD" /locus_tag="BSU_06530" /old_locus_tag="BSU06530" /label="purD gene" downshifts 660978 /Source="Nicolas_upshifts" /id="D320" /incds=0 /nref=140 /ntot=249 /MaxReadThrough="2.77191" /MaxDrop="5.90939" /score="30.0999687" /energy="-11.4" /TU="NA" /idTUdmin="U500" /TUdmin=6 /isTUend="TRUE" /label="downshifts" CDS complement(661033..661452) /gene="yezC" /locus_tag="BSU_06540" /old_locus_tag="BSU06540" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (Lrp/AsnC family)" /protein_id="NP_388536.2" /db_xref="EnsemblGenomes-Gn:BSU06540" /db_xref="EnsemblGenomes-Tr:CAB12474" /db_xref="GOA:O31497" /db_xref="InterPro:IPR000485" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR019885" /db_xref="InterPro:IPR019887" /db_xref="InterPro:IPR019888" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12874" /db_xref="UniProtKB/Swiss-Prot:O31497" /translation="MDDTDLQILSHLQRNGRLTMVELGKLVGLSSPSAAERVRKLEDK GVITGYSANICYEKLNKHVTAFILMEPKSCKHYAAFATSHPDVAENHRITGMYSYVTK VVTESVHTLEDFIDTSMAHGKPTTLVVLSSSSCHPAF*" /label="yezC CDS" gene complement(661033..661452) /gene="yezC" /locus_tag="BSU_06540" /old_locus_tag="BSU06540" /label="yezC gene" misc_feature complement(661522..661541) /Source="Nicolas_upshift_promotors" /id="U502" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig="0.999000999001" /xcortree=3125 /SigmaFactorBS="ccccctctctgattgatggctttattatagaaaaaataagac ggcatccaTATGCTACAATGAAGTTAAAtcaacagcattaccttacgatcaaaggaat t" /listShort="yezC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(661531) /Source="Nicolas_upshifts" /id="U502" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig="0.999000999001" /xcortree=3125 /SigmaFactorBS="ccccctctctgattgatggctttattatagaaaaaataagac ggcatccaTATGCTACAATGAAGTTAAAtcaacagcattaccttacgatcaaaggaat t" /listShort="yezC" /GFF_Attribute="listLong" /label="upshifts" CDS 661596..662870 /gene="yecA" /locus_tag="BSU_06550" /old_locus_tag="BSU06550" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 26319875, 27723097, 24678831; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative amino acid exporter" /protein_id="NP_388537.2" /db_xref="EnsemblGenomes-Gn:BSU06550" /db_xref="EnsemblGenomes-Tr:CAB12475" /db_xref="GOA:O34560" /db_xref="InterPro:IPR002293" /db_xref="SubtiList:BG12817" /db_xref="UniProtKB/Swiss-Prot:O34560" /translation="MLPELQRSITWIQGTALTIGAVLGCGILILPSVTADTAGPASLF VWVFMSFLSFFLVGTLARLVKIAPSAGGITAYVQLAFQKKAGAILGWIMLGSVPIGVP IIALTGAHYVSYITEAADWQITLIAGCMLAISILLHMRGIQLSANISTLVICVIVFLL VTSIAVSLPHVTIAEFKPFLPHGWSAAGSVSVMIFFSFVGWEMITPLAEEFHRPEKDV PLSLFLAASCVAGLYIMLSFVTVGTHSYGENGEIASLAMLISKGAGESGVYVTVCLAL FITFATIHANIAGFSRMVYALAREGHIPVFFGKLSATKRTPIRVLTAMAAVFGLVLAA HGLFQIDLTTLLKGPSAAFIASYICTMAAALKLLGRRDIGWWMALGAFVACAVIYSFS GWALLYPAVLAAAGYFYMKTKGGHKKKLDHVL*" /label="yecA CDS" gene 661596..662870 /gene="yecA" /locus_tag="BSU_06550" /old_locus_tag="BSU06550" /label="yecA gene" downshifts 662819 /Source="Nicolas_upshifts" /id="D321" /incds=0 /nref=4 /ntot=64 /MaxReadThrough="0.796809999999999" /MaxDrop="2.92696" /score="1.68718502" /energy="-14.2" /TU="NA" /idTUdmin="U498" /TUdmin=1825 /isTUend="FALSE" /label="downshifts" CDS complement(662885..663112) /gene="yezF" /locus_tag="BSU_06559" /old_locus_tag="BSU06559" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097691.1" /db_xref="EnsemblGenomes-Gn:BSU06559" /db_xref="EnsemblGenomes-Tr:CAX52578" /db_xref="GOA:C0H3X3" /db_xref="InterPro:IPR021309" /db_xref="UniProtKB/Swiss-Prot:C0H3X3" /translation="MKPNISLINAVFRIACGLTIMSAASAKFTKKPWCRMHLFYIFMG AMKAGSGILRFCPVTYMFQHSDSGNNEHQNG*" /label="yezF CDS" gene complement(662885..663112) /gene="yezF" /locus_tag="BSU_06559" /old_locus_tag="BSU06559" /label="yezF gene" downshifts complement(662896) /Source="Nicolas_upshifts" /id="D322" /incds=0 /nref=29 /ntot=46 /MaxReadThrough="0.14199" /MaxDrop="6.82335" /score="34.1397958" /energy="-13.9" /TU="NA" /idTUdmin="U504" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(663113..663533) /Source="Nicolas_S_feature" /locus_tag="new_713536_713956_c" /HighExp="S8, S7, S5, S6, S4, ferm, nit, BT, Pyr, T5.0H" /AntisenseName="yerA" /AntisenseCor="0.38264258041500998" /AntisenseRegPval="-10.1" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S233" promotor_-35 663180..663185 /Source="Nicolas_upshift_promotors" /id="U503" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.59040959040959" /psig=1 /xcortree=1592 /SigmaFactorBS="aaaagttttttaatcgaaccttcaaaaatttgtaacgttttt atCGTGCGtgatgaggaaggaTGTGATACCATGAGTCTAATacatgtaaaggagagta t" /listShort="yerA, yerB, yerC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 663196 /Source="Nicolas_upshifts" /id="U503" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.59040959040959" /psig=1 /xcortree=1592 /SigmaFactorBS="aaaagttttttaatcgaaccttcaaaaatttgtaacgttttt atCGTGCGtgatgaggaaggaTGTGATACCATGAGTCTAATacatgtaaaggagagta t" /listShort="yerA, yerB, yerC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 663199..663218 /Source="Nicolas_upshift_promotors" /id="U503" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.59040959040959" /psig=1 /xcortree=1592 /SigmaFactorBS="aaaagttttttaatcgaaccttcaaaaatttgtaacgttttt atCGTGCGtgatgaggaaggaTGTGATACCATGAGTCTAATacatgtaaaggagagta t" /listShort="yerA, yerB, yerC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 663241..664983 /gene="yerA" /locus_tag="BSU_06560" /old_locus_tag="BSU06560" /EC_number="3.5.4.2" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23109554; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative adenine deaminase YerA" /protein_id="NP_388538.1" /db_xref="EnsemblGenomes-Gn:BSU06560" /db_xref="EnsemblGenomes-Tr:CAB12476" /db_xref="GOA:O34909" /db_xref="InterPro:IPR006679" /db_xref="InterPro:IPR006680" /db_xref="InterPro:IPR011059" /db_xref="InterPro:IPR026912" /db_xref="InterPro:IPR032466" /db_xref="SubtiList:BG12829" /db_xref="UniProtKB/Swiss-Prot:O34909" /translation="MSERTFNWKNKDIRAQVDVVDSKLLPTLLLRNALVLNPYVKQWL KKNIWIYQDRIVYVGHELPNRAEEIHTIDCEGKYIVPGYIEPHAHPFQIYNPQTLAEY VSQYGTTTFVNDNLFLLLQSGKKKALTILNELKKQPVQYFWWSRYDLQTEVLNEDHVL PFDVRKQWIEHPDVIQGGEMTGWPRLVDGDDLMLHCMQATKKQRKRIEGHFPGASDKT LTKMKLFGADCDHEAMTGDEVMRRLELGYYVSLRNSSIRPDVRKILQELHEKGFRYYD HFFYTTDGATPNFYKGGMTNELIRIALEEGVPAIDAYNMASFNIAKYYQMDDYLGVVG PGRLASLNILEDPLNPNPVTVLSKGTILRENGCDLKAFTKTDWHKGGLVPLELSYDMT MDDLQFSMPMGVKMRNAVIMEPYMIEIDNSMEQLSFDHDESYLTMLDRHGKWRVNTMI KGFASSVQGFVSSFTTTGDIVAIGKNKADMLLAFARMKEIGGGIVLAENGNILHEIPL ALCGCASSEAYEDVLEKEQKLRDLLTERGYEFCDPIYTLLFLQSTHLPYIRITPRGIF DVMKKTVLFPSIMR*" /label="yerA CDS" gene 663241..664983 /gene="yerA" /locus_tag="BSU_06560" /old_locus_tag="BSU06560" /label="yerA gene" promotor_-10 complement(663518..663529) /Source="Nicolas_upshift_promotors" /id="U504" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=923 /SigmaFactorBS="aaaaataagttatcattcacgaatgtcgttgttccgtattga gaCACATATtccgccagtgtttGGGGATTATATAtttgaaaaggatgtgcgtgcggtt c" /listShort="S233, yezF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(663533) /Source="Nicolas_upshifts" /id="U504" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=923 /SigmaFactorBS="aaaaataagttatcattcacgaatgtcgttgttccgtattga gaCACATATtccgccagtgtttGGGGATTATATAtttgaaaaggatgtgcgtgcggtt c" /listShort="S233, yezF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(663543..663549) /Source="Nicolas_upshift_promotors" /id="U504" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=923 /SigmaFactorBS="aaaaataagttatcattcacgaatgtcgttgttccgtattga gaCACATATtccgccagtgtttGGGGATTATATAtttgaaaaggatgtgcgtgcggtt c" /listShort="S233, yezF" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 663564 /Source="Nicolas_upshifts" /id="D323" /incds=1 /nref=13 /ntot=109 /MaxReadThrough="7.92321" /MaxDrop="3.44855" /score="1.68718502" /energy="-14.2" /TU="U503" /idTUdmin="U498" /TUdmin=2570 /isTUend="FALSE" /label="downshifts" promotor_-35 664957..664963 /Source="Nicolas_upshift_promotors" /id="U505" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.4995004995005" /psig="0.996003996003996" /xcortree=2171 /SigmaFactorBS="cgcattacgccaagaggaatattcgacgtcatgaaaaaaact GTACTCTttccatcgataaTGCGTTAAAATATAAAAGAGcagggagccgacatatgaa a" /listShort="yerB, yerC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 664975 /Source="Nicolas_upshifts" /id="U505" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.4995004995005" /psig="0.996003996003996" /xcortree=2171 /SigmaFactorBS="cgcattacgccaagaggaatattcgacgtcatgaaaaaaact GTACTCTttccatcgataaTGCGTTAAAATATAAAAGAGcagggagccgacatatgaa a" /listShort="yerB, yerC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 664976..664995 /Source="Nicolas_upshift_promotors" /id="U505" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.4995004995005" /psig="0.996003996003996" /xcortree=2171 /SigmaFactorBS="cgcattacgccaagaggaatattcgacgtcatgaaaaaaact GTACTCTttccatcgataaTGCGTTAAAATATAAAAGAGcagggagccgacatatgaa a" /listShort="yerB, yerC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 665010..666005 /gene="yerB" /locus_tag="BSU_06570" /old_locus_tag="BSU06570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12073041; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_388539.1" /db_xref="EnsemblGenomes-Gn:BSU06570" /db_xref="EnsemblGenomes-Tr:CAB12477" /db_xref="GOA:O34968" /db_xref="InterPro:IPR021416" /db_xref="InterPro:IPR023158" /db_xref="InterPro:IPR035328" /db_xref="PDB:2PSB" /db_xref="SubtiList:BG12830" /db_xref="UniProtKB/Swiss-Prot:O34968" /translation="MKKWMTVCALCFVFFLLVSCQQKDAVPDTAKKLKAPLTGLKTEQ KVTERRPVAVVVNNHPKARPQSGLSKADIVIEALAEGQITRFLAIFQSQMPETVGPVR SAREYFVTLSNGFDSIFVHHGWSPGAKKQLESGAADYMNGLDFDGSLFWRADFSKPPH NSYTSYDYIKKAAEQKGYKLKQETNPLLFQTSDAKPANESYNVRVDYGTNNVTNLVEY NYDKKAEFYTRSSDGVITTDRETGKPVAMQNIFIVEASHHIIDQDGRRDIDLESGGKG LLFQHGNVIETDWKQVNGRIVPVKDGKWLPFVPGKTWINIVPDLDAASISKGEGV*" /label="yerB CDS" gene 665010..666005 /gene="yerB" /locus_tag="BSU_06570" /old_locus_tag="BSU06570" /label="yerB gene" CDS 666008..666322 /gene="yerC" /locus_tag="BSU_06580" /old_locus_tag="BSU06580" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 23504016, 26735940; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor-histidine operons" /protein_id="NP_388540.1" /db_xref="EnsemblGenomes-Gn:BSU06580" /db_xref="EnsemblGenomes-Tr:CAB12478" /db_xref="GOA:Q7BVT7" /db_xref="InterPro:IPR000831" /db_xref="InterPro:IPR010921" /db_xref="InterPro:IPR013368" /db_xref="SubtiList:BG12831" /db_xref="UniProtKB/Swiss-Prot:Q7BVT7" /translation="MQIDKLRGKELDQLFNSILSLKDLEECYRFFDDLCTINEIQSLA QRLEVARMLREGNTYHKIETETGASTATISRVKRCLNYGNDAYEMALDRVKETETESS SK*" /label="yerC CDS" gene 666008..666322 /gene="yerC" /locus_tag="BSU_06580" /old_locus_tag="BSU06580" /label="yerC gene" downshifts 666185 /Source="Nicolas_upshifts" /id="D324" /incds=1 /nref=1 /ntot=25 /MaxReadThrough="7.1005" /MaxDrop="2.3494" /score="10.9674476" /energy="-15.8" /TU="U503,U505" /idTUdmin="U503" /TUdmin="-374" /isTUend="FALSE" /label="downshifts" downshifts 666327 /Source="Nicolas_upshifts" /id="D325" /incds=0 /nref=78 /ntot=262 /MaxReadThrough="3.58776" /MaxDrop="5.59364" /score="10.9674476" /energy="-15.8" /TU="U503,U505" /idTUdmin="U503" /TUdmin="-232" /isTUend="FALSE" /label="downshifts" CDS complement(666357..667934) /gene="yerD" /locus_tag="BSU_06590" /old_locus_tag="BSU06590" /EC_number="1.4.1.13" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15805528, 17114254, 19948795; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative osmotic shock glutamate synthase subunit (flavoprotein subunit, ferredoxin-dependent)" /protein_id="NP_388541.1" /db_xref="EnsemblGenomes-Gn:BSU06590" /db_xref="EnsemblGenomes-Tr:CAB12479" /db_xref="GOA:O34849" /db_xref="InterPro:IPR002932" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR024188" /db_xref="InterPro:IPR027283" /db_xref="SubtiList:BG12832" /db_xref="UniProtKB/Swiss-Prot:O34849" /translation="METIIIALIAFIIGIIAIPIVLFAWIYIKDEKQQEHSILRNYPV IGRFRYILEKIGPELRQYLYSNDNEEQPFSRKEYEQTVISGKYKSRMMGFGSVRDFDK PGYYIRNAMFPKQREEMHVNQTPKIETQIYKMDADNLFKRKEHAEHIKADPYFLHPDD VQVIGEHTCEKPFYVKGLVGQSAMSYGSLGERAVTALSKGLHLAGGTWMNTGEGGLSE YHLKGGADIICQIGPGLFGVRKRNGEFSWEEFKRKSRIDQIKAFELKLAQGAKTRGGH VDGAKVSEEVADIRNVEPGKSIDSPNRFYEFSNPPEMLDFIEKLRDVGQKPVGIKLVA GHPEELHELFSHMQKSGKHPDFITIDGSEGGTGASFYELADTVGLPIMTALPIVDTLL KQYGLRSQLKIFASGKLLTPDKIAVALALGADFVNIARGMMFSVGCIRALVCHTNTCP AGVATTDPKLQKALSVEEKQHRVCNYVISLREGLFNLAAAAGINSPIHFSKEHVVYRK EDGSIINIDNLIHQFVS*" /label="yerD CDS" gene complement(666357..667934) /gene="yerD" /locus_tag="BSU_06590" /old_locus_tag="BSU06590" /label="yerD gene" downshifts complement(666371) /Source="Nicolas_upshifts" /id="D326" /incds=0 /nref=7 /ntot=24 /MaxReadThrough="2.99325" /MaxDrop="5.6389" /score="34.8793815" /energy="-15.8" /TU="U506" /idTUdmin="U506" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(667948..667967) /Source="Nicolas_upshift_promotors" /id="U506" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=244 /SigmaFactorBS="ggcaggagcacacatttttcaccagattccttctgctatTGT TTGGaaagtgttctactgTGGAAATGGTTACATAAAAAgggaggctgagagatggaaa c" /listShort="yerD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(667967) /Source="Nicolas_upshifts" /id="U506" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=244 /SigmaFactorBS="ggcaggagcacacatttttcaccagattccttctgctatTGT TTGGaaagtgttctactgTGGAAATGGTTACATAAAAAgggaggctgagagatggaaa c" /listShort="yerD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(667982..667988) /Source="Nicolas_upshift_promotors" /id="U506" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=244 /SigmaFactorBS="ggcaggagcacacatttttcaccagattccttctgctatTGT TTGGaaagtgttctactgTGGAAATGGTTACATAAAAAgggaggctgagagatggaaa c" /listShort="yerD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 668131..668134 /Source="Nicolas_upshift_promotors" /id="U507" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2610 /SigmaFactorBS="aaaacacctttttcagtgaataacgagattaacggctttttc cGTTTttccgcgctatgtgaaTTTGTTATAATGTTTAAATGgtaacaaacgaatggag g" /listShort="pcrB, pcrA, ligA, yerH, S234, yerI" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 668148 /Source="Nicolas_upshifts" /id="U507" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2610 /SigmaFactorBS="aaaacacctttttcagtgaataacgagattaacggctttttc cGTTTttccgcgctatgtgaaTTTGTTATAATGTTTAAATGgtaacaaacgaatggag g" /listShort="pcrB, pcrA, ligA, yerH, S234, yerI" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 668151..668170 /Source="Nicolas_upshift_promotors" /id="U507" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2610 /SigmaFactorBS="aaaacacctttttcagtgaataacgagattaacggctttttc cGTTTttccgcgctatgtgaaTTTGTTATAATGTTTAAATGgtaacaaacgaatggag g" /listShort="pcrB, pcrA, ligA, yerH, S234, yerI" /GFF_Attribute="listLong" /label="promotor_-10" CDS 668199..668885 /gene="pcrB" /locus_tag="BSU_06600" /old_locus_tag="BSU06600" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16377641, 21761520, 21214173, 27226549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16377641, 21761520, 21214173, 27226549; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="heptaprenylglyceryl-phosphate synthase" /protein_id="NP_388542.1" /db_xref="EnsemblGenomes-Gn:BSU06600" /db_xref="EnsemblGenomes-Tr:CAB12480" /db_xref="GOA:O34790" /db_xref="InterPro:IPR008205" /db_xref="PDB:1VIZ" /db_xref="PDB:3VZX" /db_xref="PDB:3VZY" /db_xref="PDB:3VZZ" /db_xref="PDB:3W00" /db_xref="SubtiList:BG12833" /db_xref="UniProtKB/Swiss-Prot:O34790" /translation="MYDVTEWKHVFKLDPNKDLPDEQLEILCESGTDAVIIGGSDGVT EDNVLRMMSKVRRFLVPCVLEVSAIEAIVPGFDLYFIPSVLNSKNADWIVGMHQKAMK EYGELMSMEEIVAEGYCIANPDCKAAALTEADADLNMDDIVAYARVSELLQLPIFYLE YSGVLGDIEAVKKTKAVLETSTLFYGGGIKDAETAKQYAEHADVIVVGNAVYEDFDRA LKTVAAVKGE*" /label="pcrB CDS" gene 668199..668885 /gene="pcrB" /locus_tag="BSU_06600" /old_locus_tag="BSU06600" /label="pcrB gene" CDS 668947..671166 /gene="pcrA" /locus_tag="BSU_06610" /old_locus_tag="BSU06610" /EC_number="3.6.4.12" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12073041, 12682299, 14594837, 16267290, 26070154; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent DNA helicase" /protein_id="NP_388543.1" /db_xref="EnsemblGenomes-Gn:BSU06610" /db_xref="EnsemblGenomes-Tr:CAB12481" /db_xref="GOA:O34580" /db_xref="InterPro:IPR000212" /db_xref="InterPro:IPR005751" /db_xref="InterPro:IPR014016" /db_xref="InterPro:IPR014017" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR034739" /db_xref="SubtiList:BG12834" /db_xref="UniProtKB/Swiss-Prot:O34580" /translation="MNYISNQLLSGLNPVQQEAVKTTDGPLLLMAGAGSGKTRVLTHR IAYLMAEKHVAPWNILAITFTNKAAREMKERVESILGPGADDIWISTFHSMCVRILRR DIDRIGINRNFSILDTADQLSVIKGILKERNLDPKKFDPRSILGTISSAKNELTEPEE FSKVAGGYYDQVVSDVYADYQKKLLKNQSLDFDDLIMTTIKLFDRVPEVLEFYQRKFQ YIHVDEYQDTNRAQYMLVKQLAERFQNLCVVGDSDQSIYRWRGADITNILSFEKDYPN ASVILLEQNYRSTKRILRAANEVIKNNSNRKPKNLWTENDEGIKISYYRGDNEFGEGQ FVAGKIHQLHSTGKRKLSDIAILYRTNAQSRVIEETLLKAGLNYNIVGGTKFYDRKEI KDILAYLRLVSNPDDDISFTRIVNVPKRGVGATSLEKIASYAAINGLSFFQAIQQVDF IGVSAKAANALDSFRQMIENLTNMQDYLSITELTEEILDKTEYREMLKAEKSIEAQSR LENIDEFLSVTKNFEQKSEDKTLVAFLTDLALIADIDQLDQKEEESGGKDAITLMTLH AAKGLEFPVVFLMGLEEGVFPHSRSLMEEAEMEEERRLAYVGITRAEQELYLTNAKMR TLFGRTNMNPESRFIAEIPDDLLENLNEKKETRATSARKMQPRRGPVSRPVSYASKTG GDTLNWAVGDKAGHKKWGTGTVVSVKGEGEGTELDIAFPSPVGVKRLLAAFAPIEKQ* " /label="pcrA CDS" gene 668947..671166 /gene="pcrA" /locus_tag="BSU_06610" /old_locus_tag="BSU06610" /label="pcrA gene" CDS 671190..673196 /gene="ligA" /locus_tag="BSU_06620" /old_locus_tag="BSU06620" /EC_number="6.5.1.2" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:164915, 11095673, 12682299, 16267290" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 164915, 11095673, 12682299, 16267290; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA ligase (NAD-dependent)" /protein_id="NP_388544.1" /db_xref="EnsemblGenomes-Gn:BSU06620" /db_xref="EnsemblGenomes-Tr:CAB12482" /db_xref="GOA:O31498" /db_xref="InterPro:IPR001357" /db_xref="InterPro:IPR001679" /db_xref="InterPro:IPR003583" /db_xref="InterPro:IPR004149" /db_xref="InterPro:IPR004150" /db_xref="InterPro:IPR010994" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR013839" /db_xref="InterPro:IPR013840" /db_xref="InterPro:IPR018239" /db_xref="InterPro:IPR033136" /db_xref="InterPro:IPR036420" /db_xref="SubtiList:BG12835" /db_xref="UniProtKB/Swiss-Prot:O31498" /translation="MDKETAKQRAEELRRTINKYSYEYYTLDEPSVPDAEYDRLMQEL IAIEEEHPDLRTPDSPTQRVGGAVLEAFQKVTHGTPMLSLGNAFNADDLRDFDRRVRQ SVGDDVAYNVELKIDGLAVSLRYEDGYFVRGATRGDGTTGEDITENLKTIRNIPLKMN RELSIEVRGEAYMPKRSFEALNEERIKNEEEPFANPRNAAAGSLRQLDPKIAAKRNLD IFVYSIAELDEMGVETQSQGLDFLDELGFKTNQERKKCGSIEEVITLIDELQAKRADL PYEIDGIVIKVDSLDQQEELGFTAKSPRWAIAYKFPAEEVVTKLLDIELNVGRTGVIT PTAILEPVKVAGTTVSRASLHNEDLIKEKDIRILDKVVVKKAGDIIPEVVNVLVDQRT GEEKEFSMPTECPECGSELVRIEGEVALRCINPECPAQIREGLIHFVSRNAMNIDGLG ERVITQLFEENLVRNVADLYKLTKERVIQLERMGEKSTENLISSIQKSKENSLERLLF GLGIRFIGSKAAKTLAMHFESLENLKKASKEELLAVDEIGEKMADAVITYFHKEEMLE LLNELQELGVNTLYKGPKKVKAEDSDSYFAGKTIVLTGKLEELSRNEAKAQIEALGGK LTGSVSKNTDLVIAGEAAGSKLTKAQELNIEVWNEEQLMGELKK*" /label="ligA CDS" gene 671190..673196 /gene="ligA" /locus_tag="BSU_06620" /old_locus_tag="BSU06620" /label="ligA gene" CDS 673212..674402 /gene="yerH" /locus_tag="BSU_06630" /old_locus_tag="BSU06630" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16267290; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_388545.1" /db_xref="EnsemblGenomes-Gn:BSU06630" /db_xref="EnsemblGenomes-Tr:CAB12483" /db_xref="GOA:O34629" /db_xref="InterPro:IPR011426" /db_xref="SubtiList:BG12836" /db_xref="UniProtKB/Swiss-Prot:O34629" /translation="MKKTLALAATAAVLMLSACSSGFGGEKEEEITQKTAKSSEKAIV PKYNISDSYYKMVLPFKAGKARGLTTEQLNTRLDIDEFETGLMRLAQDSFSTDDYLFQ EGQYLDEDTVLSWLARKKTGSDLKKAEKEDKNFKNEGLNPALPSSGSTEEKNESSPIY LASMLEHDYLVRKDKNSIQLGGVMIGLALNSVYYYREKTGDPQKEVEIKDSTLRQQGE KIAQEVINRLRKKDNLKNVPITVALYKQASKTSIVPGNFIAKTEVKAGSTDISNWDDI NEKYVFYPADTTTAEKYPDDTEVFKRFKNSIEEYFPNYTGVVGTALYENDEMKKMKID IPMQFYGKSEVVAFTQFLTGEVMDYYSKSSVDVEVNITSSDGQEAVIIRNAGDKEPTV HIYD*" /label="yerH CDS" gene 673212..674402 /gene="yerH" /locus_tag="BSU_06630" /old_locus_tag="BSU06630" /label="yerH gene" misc_feature complement(673407..673411) /Source="Nicolas_upshift_promotors" /id="U508" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.986013986013986" /psig="0.000999000999001" /xcortree=36 /SigmaFactorBS="atcagccctgtttcaaattcgtcaatgtccagccttgtattc agctgttccgttgttaagCCGCGcgctttgcctgccttaaacggcagcaccattttgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(673411) /Source="Nicolas_upshifts" /id="U508" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.986013986013986" /psig="0.000999000999001" /xcortree=36 /SigmaFactorBS="atcagccctgtttcaaattcgtcaatgtccagccttgtattc agctgttccgttgttaagCCGCGcgctttgcctgccttaaacggcagcaccattttgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 674439..674458 /Source="Nicolas_upshift_promotors" /id="U509" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=3168 /SigmaFactorBS="tcacatttatgactgatagaaaacccttgtgccatattggca caagggttttTATGTTACAATTAACAGGAAaagggaaaatattttcacttctgccgaa a" /listShort="S234, yerI" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 674447..674563 /Source="Nicolas_S_feature" /locus_tag="new_724870_724986" /HighExp="LoTm, B60, Lbstat, B36, BI, M9-stat, T1.30H, ferm, T3.30H, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S234" upshifts 674447 /Source="Nicolas_upshifts" /id="U509" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=3168 /SigmaFactorBS="tcacatttatgactgatagaaaacccttgtgccatattggca caagggttttTATGTTACAATTAACAGGAAaagggaaaatattttcacttctgccgaa a" /listShort="S234, yerI" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(674511) /Source="Nicolas_upshifts" /id="D327" /incds=0 /nref=2 /ntot=118 /MaxReadThrough="1.21197" /MaxDrop="3.77048" /score="18.5253059" /energy="-17.7" /TU="NA" /idTUdmin="U511" /TUdmin=1122 /isTUend="FALSE" /label="downshifts" CDS 674564..675574 /gene="yerI" /locus_tag="BSU_06640" /old_locus_tag="BSU06640" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative kinase" /protein_id="NP_388546.1" /db_xref="EnsemblGenomes-Gn:BSU06640" /db_xref="EnsemblGenomes-Tr:CAB12484" /db_xref="InterPro:IPR002575" /db_xref="InterPro:IPR011009" /db_xref="SubtiList:BG12837" /db_xref="UniProtKB/Swiss-Prot:O34640" /translation="MLDVHKDIKKIFHEEQVLAEAAARYGFSKDQVRFLADAENYVYE CMKDNQPYILKITHTIRRSSDYMMGEMEWLRHLAIGGISVAKPLPSLNGKDVEAVPDG NGGSFLLRVYEKAPGQKVDESDWNETLFYELGRYTGSMHSLTKSYKLSNPAFKRQEWD EEEQLKLRKYVPEDQIKVFQQADSLMNELRRLPKSQDNYGLVHADLHHGNFNWDHGKI TAFDFDDIGYNWFVNDISILLYNVLWYPVVPYDDKAAFTEEFMTHFMKGYWEENELDP AWLMIIPDFLRLRHMLIYGLLHQMFDLNTIGEEEKEMLAGFRRDIENGTPITAFDFSA LV*" /label="yerI CDS" gene 674564..675574 /gene="yerI" /locus_tag="BSU_06640" /old_locus_tag="BSU06640" /label="yerI gene" promotor_no_box complement(674581..674681) /Source="Nicolas_upshift_promotors" /id="U510" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.993006993006993" /psig=0 /xcortree=53 /SigmaFactorBS="tttccgcatcagccagaaaacgcacctgatcttttgagaaac cgtatctcgctgcagcttctgccaaaacctgctcttcatgaaatatttttttgatatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(674621) /Source="Nicolas_upshifts" /id="U510" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.993006993006993" /psig=0 /xcortree=53 /SigmaFactorBS="tttccgcatcagccagaaaacgcacctgatcttttgagaaac cgtatctcgctgcagcttctgccaaaacctgctcttcatgaaatatttttttgatatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 675557 /Source="Nicolas_upshifts" /id="D328" /incds=0 /nref=137 /ntot=253 /MaxReadThrough="3.07041" /MaxDrop="5.10987" /score="12.7441524" /energy="-17" /TU="NA" /idTUdmin="U507" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 675601..676405 /Source="Nicolas_S_feature" /locus_tag="new_726024_726828" /HighExp="B60, B36, LoTm, M9-stat, Cold, T1.30H, T0.30H, ferm, Lbstat, LBGstat" /AntisenseName="sapB" /AntisenseCor="-0.57665624439942198" /AntisenseRegPval="-24.5" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S235" CDS complement(675612..676310) /gene="sapB" /locus_tag="BSU_06650" /old_locus_tag="BSU06650" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 410907, 9043134, 14708580, 27350030, 28181542; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative magnesium transporter" /protein_id="NP_388547.1" /db_xref="EnsemblGenomes-Gn:BSU06650" /db_xref="EnsemblGenomes-Tr:CAB12485" /db_xref="GOA:Q45514" /db_xref="InterPro:IPR003416" /db_xref="SubtiList:BG11845" /db_xref="UniProtKB/Swiss-Prot:Q45514" /translation="MLLSWYIDPDILLKLGIATLIGMVIGLERELKNKPLGLKTCIVI AVSSCMLTIVSINAAYHFPKYYRIMMDPLRLPAQIISGVGFIGAGVILRKSNDVISGL TTSAMIWGAAGLGLATGAGFYKEAFASLLFILISVEFLPWVVRKIGPDRLQEKDIRIR MSLSDKDKMTEILKEMKRRDIKAHSVRIDDLGEKDFPIMEVKVRVHKNRYTTDVYYDI KAIEGVVGVKCDTL*" /label="sapB CDS" gene complement(675612..676310) /gene="sapB" /locus_tag="BSU_06650" /old_locus_tag="BSU06650" /label="sapB gene" downshifts complement(675633) /Source="Nicolas_upshifts" /id="D329" /incds=0 /nref=26 /ntot=129 /MaxReadThrough="2.5379" /MaxDrop="3.83708" /score="20.8493264" /energy="-16.2" /TU="NA" /idTUdmin="U511" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(676330..676348) /Source="Nicolas_upshift_promotors" /id="U511" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.684315684315684" /psig="0.684315684315684" /xcortree=1465 /SigmaFactorBS="aagccatcaagcgcagcttggtggcttttgtgctcttgtttt GCTATAaatactgtgagaaaaTCATATTTATTTAAAAACAccatagagaagggggaag t" /listShort="sapB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(676351) /Source="Nicolas_upshifts" /id="U511" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.684315684315684" /psig="0.684315684315684" /xcortree=1465 /SigmaFactorBS="aagccatcaagcgcagcttggtggcttttgtgctcttgtttt GCTATAaatactgtgagaaaaTCATATTTATTTAAAAACAccatagagaagggggaag t" /listShort="sapB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(676364..676369) /Source="Nicolas_upshift_promotors" /id="U511" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.684315684315684" /psig="0.684315684315684" /xcortree=1465 /SigmaFactorBS="aagccatcaagcgcagcttggtggcttttgtgctcttgtttt GCTATAaatactgtgagaaaaTCATATTTATTTAAAAACAccatagagaagggggaag t" /listShort="sapB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(676417..677895) /gene="opuE" /locus_tag="BSU_06660" /old_locus_tag="BSU06660" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9701821, 11902719, 14996799, 15849754, 16850406, 17183215, 22685134" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9701821, 11902719, 14996799, 15849754, 16850406, 17183215, 22685134; Product type t: transporter" /codon_start=1 /transl_table=11 /product="proline transporter" /protein_id="NP_388548.1" /db_xref="EnsemblGenomes-Gn:BSU06660" /db_xref="EnsemblGenomes-Tr:CAB12486" /db_xref="GOA:O06493" /db_xref="InterPro:IPR001734" /db_xref="InterPro:IPR011851" /db_xref="InterPro:IPR018212" /db_xref="SubtiList:BG12641" /db_xref="UniProtKB/Swiss-Prot:O06493" /translation="MSIEIIISLGIYFIAMLLIGWYAFKKTTDINDYMLGGRGLGPFV TALSAGAADMSGWMLMGVPGAMFATGLSTLWLALGLTIGAYSNYLLLAPRLRAYTEAA DDAITIPDFFDKRFQHSSSLLKIVSALIIMIFFTLYTSSGMVSGGRLFESAFGADYKL GLFLTTAVVVLYTLFGGFLAVSLTDFVQGAIMFAALVLVPIVAFTHVGGVAPTFHEID AVNPHLLDIFKGASVISIISYLAWGLGYYGQPHIIVRFMAIKDIKDLKPARRIGMSWM IITVLGSVLTGLIGVAYAHKFGVAVKDPEMIFIIFSKILFHPLITGFLLSAILAAIMS SISSQLLVTASAVTEDLYRSFFRRKASDKELVMIGRLSVLVIAVIAVLLSLNPNSTIL DLVGYAWAGFGSAFGPAILLSLYWKRMNEWGALAAMIVGAATVLIWITTGLAKSTGVY EIIPGFILSMIAGIIVSMITKRPAKASYRLFGVMEKLLKRKK*" /label="opuE CDS" gene complement(676417..677895) /gene="opuE" /locus_tag="BSU_06660" /old_locus_tag="BSU06660" /label="opuE gene" downshifts complement(676431) /Source="Nicolas_upshifts" /id="D330" /incds=0 /nref=43 /ntot=142 /MaxReadThrough="5.35634" /MaxDrop="4.34381" /score="9.43100511" /energy="-13.8" /TU="U512,U513" /idTUdmin="U511" /TUdmin="-798" /isTUend="FALSE" /label="downshifts" upshifts complement(677283) /Source="Nicolas_upshifts" /id="U512" /multdbtbs="-" /comp="M18" /sig="Sig-" /pcomp="0.475524475524476" /psig="0.475524475524476" /xcortree=138 /SigmaFactorBS="gacttcgtgcagggtgcgatcatgtttgcagcactagtgctt gtGCCGATCGTTGCTTttacccatgtgggcggcgttgctccgactttccatgaaatcg a" /listShort="sapB" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(677286..677299) /Source="Nicolas_upshift_promotors" /id="U512" /multdbtbs="-" /comp="M18" /sig="Sig-" /pcomp="0.475524475524476" /psig="0.475524475524476" /xcortree=138 /SigmaFactorBS="gacttcgtgcagggtgcgatcatgtttgcagcactagtgctt gtGCCGATCGTTGCTTttacccatgtgggcggcgttgctccgactttccatgaaatcg a" /listShort="sapB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature complement(677896..678026) /Source="Nicolas_S_feature" /locus_tag="new_728319_728449_c" /HighExp="Salt, HiOs, Etha, Gly, MG 25, MG 45, M9-exp, MG t5, MG 15, GM 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.954" /TUlongSig="NA" /TUlongPSig="NA" /label="S236" promotor_-10 complement(678017..678035) /Source="Nicolas_upshift_promotors" /id="U513" /multdbtbs="SigA,SigB" /comp="M11" /sig="SigB" /pcomp="0.954045954045954" /psig="0.954045954045954" /xcortree=137 /SigmaFactorBS="tttgcaacggtatttccagcttatgatcaaTGTTTCAtcgct tgaatggccGGGAATACTTTGTTAGGTTaagttaccaagtgcacccgcaaaagaattt c" /listShort="S236, opuE, sapB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(678026) /Source="Nicolas_upshifts" /id="U513" /multdbtbs="SigA,SigB" /comp="M11" /sig="SigB" /pcomp="0.954045954045954" /psig="0.954045954045954" /xcortree=137 /SigmaFactorBS="tttgcaacggtatttccagcttatgatcaaTGTTTCAtcgct tgaatggccGGGAATACTTTGTTAGGTTaagttaccaagtgcacccgcaaaagaattt c" /listShort="S236, opuE, sapB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(678050..678056) /Source="Nicolas_upshift_promotors" /id="U513" /multdbtbs="SigA,SigB" /comp="M11" /sig="SigB" /pcomp="0.954045954045954" /psig="0.954045954045954" /xcortree=137 /SigmaFactorBS="tttgcaacggtatttccagcttatgatcaaTGTTTCAtcgct tgaatggccGGGAATACTTTGTTAGGTTaagttaccaagtgcacccgcaaaagaattt c" /listShort="S236, opuE, sapB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 678157..678160 /Source="Nicolas_upshift_promotors" /id="U514" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.88011988011988" /psig="0.999000999001" /xcortree=2562 /SigmaFactorBS="ttcaaaaaataattaaagtaaaaatattcagaaaaatatttc GTTTctccttctcctcatttTAGTATAAAATATATAGGGTattgtttcgaaaacacag g" /listShort="S237, gatC, gatA, gatB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 678175..678308 /Source="Nicolas_S_feature" /locus_tag="new_728598_728731" /HighExp="G180, G150, LBGexp, Oxctl, Paraq, dia0, G135, Lbexp, H2O2, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S237" upshifts 678175 /Source="Nicolas_upshifts" /id="U514" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.88011988011988" /psig="0.999000999001" /xcortree=2562 /SigmaFactorBS="ttcaaaaaataattaaagtaaaaatattcagaaaaatatttc GTTTctccttctcctcatttTAGTATAAAATATATAGGGTattgtttcgaaaacacag g" /listShort="S237, gatC, gatA, gatB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 678177..678196 /Source="Nicolas_upshift_promotors" /id="U514" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.88011988011988" /psig="0.999000999001" /xcortree=2562 /SigmaFactorBS="ttcaaaaaataattaaagtaaaaatattcagaaaaatatttc GTTTctccttctcctcatttTAGTATAAAATATATAGGGTattgtttcgaaaacacag g" /listShort="S237, gatC, gatA, gatB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 678309..678599 /gene="gatC" /locus_tag="BSU_06670" /old_locus_tag="BSU06670" /EC_number="6.3.5.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9342321, 11445070, 12682299, 25005615" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9342321, 11445070, 12682299, 25005615; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamyl-tRNA(Gln) amidotransferase (subunit C)" /protein_id="NP_388549.1" /db_xref="EnsemblGenomes-Gn:BSU06670" /db_xref="EnsemblGenomes-Tr:CAB12487" /db_xref="GOA:O06492" /db_xref="InterPro:IPR003837" /db_xref="InterPro:IPR036113" /db_xref="SubtiList:BG12838" /db_xref="UniProtKB/Swiss-Prot:O06492" /translation="MSRISIEEVKHVAHLARLAITEEEAKMFTEQLDSIISFAEELNE VNTDNVEPTTHVLKMKNVMREDEAGKGLPVEDVMKNAPDHKDGYIRVPSILD*" /label="gatC CDS" gene 678309..678599 /gene="gatC" /locus_tag="BSU_06670" /old_locus_tag="BSU06670" /label="gatC gene" CDS 678615..680072 /gene="gatA" /locus_tag="BSU_06680" /old_locus_tag="BSU06680" /EC_number="6.3.5.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11445070, 12682299, 9342321" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11445070, 12682299, 9342321; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamyl-tRNA(Gln) amidotransferase (subunit A)" /protein_id="NP_388550.1" /db_xref="EnsemblGenomes-Gn:BSU06680" /db_xref="EnsemblGenomes-Tr:CAB12488" /db_xref="GOA:O06491" /db_xref="InterPro:IPR000120" /db_xref="InterPro:IPR004412" /db_xref="InterPro:IPR020556" /db_xref="InterPro:IPR023631" /db_xref="InterPro:IPR036928" /db_xref="SubtiList:BG12839" /db_xref="UniProtKB/Swiss-Prot:O06491" /translation="MSLFDHKITELKQLIHKKEIKISDLVDESYKRIQAVDDKVQAFL ALDEERARAYAKELDEAVDGRSEHGLLFGMPIGVKDNIVTKGLRTTCSSKILENFDPI YDATVVQRLQDAEAVTIGKLNMDEFAMGSSTENSAYKLTKNPWNLDTVPGGSSGGSAA AVAAGEVPFSLGSDTGGSIRQPASFCGVVGLKPTYGRVSRYGLVAFASSLDQIGPITR TVEDNAFLLQAISGVDKMDSTSANVDVPDFLSSLTGDIKGLKIAVPKEYLGEGVGKEA RESVLAALKVLEGLGATWEEVSLPHSKYALATYYLLSSSEASANLARFDGIRYGYRTD NADNLIDLYKQTRAEGFGNEVKRRIMLGTFALSSGYYDAYYKKAQKVRTLIKKDFEDV FEKYDVIVGPTTPTPAFKIGENTKDPLTMYANDILTIPVNLAGVPGISVPCGLADGLP LGLQIIGKHFDESTVYRVAHAFEQATDHHKAKPEL*" /label="gatA CDS" gene 678615..680072 /gene="gatA" /locus_tag="BSU_06680" /old_locus_tag="BSU06680" /label="gatA gene" CDS 680086..681516 /gene="gatB" /locus_tag="BSU_06690" /old_locus_tag="BSU06690" /EC_number="6.3.5.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11445070, 12682299, 9342321" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11445070, 12682299, 9342321; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamyl-tRNA(Gln) amidotransferase (subunit B)" /protein_id="NP_388551.2" /db_xref="EnsemblGenomes-Gn:BSU06690" /db_xref="EnsemblGenomes-Tr:CAB12489" /db_xref="GOA:O30509" /db_xref="InterPro:IPR003789" /db_xref="InterPro:IPR004413" /db_xref="InterPro:IPR006075" /db_xref="InterPro:IPR014746" /db_xref="InterPro:IPR017958" /db_xref="InterPro:IPR017959" /db_xref="InterPro:IPR018027" /db_xref="InterPro:IPR023168" /db_xref="SubtiList:BG12840" /db_xref="UniProtKB/Swiss-Prot:O30509" /translation="MNFETVIGLEVHVELKTKSKIFSSSPTPFGAEANTQTSVIDLGY PGVLPVLNKEAVEFAMKAAMALNCEIATDTKFDRKNYFYPDNPKAYQISQFDKPIGEN GWIEIEVGGKTKRIGITRLHLEEDAGKLTHTGDGYSLVDFNRQGTPLVEIVSEPDIRT PEEAYAYLEKLKSIIQYTGVSDCKMEEGSLRCDANISLRPIGQEEFGTKTELKNLNSF AFVQKGLEHEEKRQEQVLLSGGVIQQETRRYDEATKKTILMRVKEGSDDYRYFPEPDL VELYIDDEWKERVKASIPELPDERRKRYIEELGLPAYDAMVLTLTKEMADFFEETVQK GAEAKQASNWLMGEVSAYLNAEQKELADVALTPEGLAGMIKLIEKGTISSKIAKKVFK ELIEKGGDAEKIVKEKGLVQISDEGVLLKLVTEALDNNPQSIEDFKNGKDRAIGFLVG QIMKASKGQANPPMVNKILLEEIKKR*" /label="gatB CDS" gene 680086..681516 /gene="gatB" /locus_tag="BSU_06690" /old_locus_tag="BSU06690" /label="gatB gene" downshifts 681497 /Source="Nicolas_upshifts" /id="D331" /incds=0 /nref=257 /ntot=266 /MaxReadThrough="1.62334" /MaxDrop="8.77378" /score="26.1218607" /energy="-9.6" /TU="NA" /idTUdmin="U514" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(681531..682400) /gene="yerO" /locus_tag="BSU_06700" /old_locus_tag="BSU06700" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (TetR/AcrR family)" /protein_id="NP_388552.1" /db_xref="EnsemblGenomes-Gn:BSU06700" /db_xref="EnsemblGenomes-Tr:CAB12490" /db_xref="GOA:O31500" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR023772" /db_xref="SubtiList:BG12841" /db_xref="UniProtKB/Swiss-Prot:O31500" /translation="MNEKKERIIKTSIRLFAKKGFAATTIQEIASECGISKGAFYLHF KSKEALLLSACEYYIGMSMNKMKNIEEDLAGKPPKEVLKKQIGAQFEDFRDHKDFIVL LLTENIIPENQEIKQYFYKVTMETDKLYRNALLVSYGEGIERYVADLSIMARGIVHSY MNVMVFNGELNIDAEEISAFIIERLDDLVQGLSRSALNPIVSKDIFNPMPAGKDQLLE DIQKVKENSTLPEDITVSLDVIEEELTQDKPRKPIIKGMLSNLAGTNDKEVERLRALI LSLSQFDHKKSSL*" /label="yerO CDS" gene complement(681531..682400) /gene="yerO" /locus_tag="BSU_06700" /old_locus_tag="BSU06700" /label="yerO gene" downshifts complement(681573) /Source="Nicolas_upshifts" /id="D332" /incds=0 /nref=122 /ntot=211 /MaxReadThrough="2.21801" /MaxDrop="4.89305" /score="32.2694333" /energy="-11.4" /TU="NA" /idTUdmin="U517" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 682190..682195 /Source="Nicolas_upshift_promotors" /id="U515" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.822177822177822" /psig="0.822177822177822" /xcortree=1398 /SigmaFactorBS="ccttaggcggctttccggcgagatcttCTTCTAtatttttca ttttgtTCATAGACATACCGATATAatattcacaggcagataacagcagcgcttcttt c" /GFF_Attribute="listShort" /listLong="swrC" /label="promotor_-35" promotor_-10 682211..682229 /Source="Nicolas_upshift_promotors" /id="U515" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.822177822177822" /psig="0.822177822177822" /xcortree=1398 /SigmaFactorBS="ccttaggcggctttccggcgagatcttCTTCTAtatttttca ttttgtTCATAGACATACCGATATAatattcacaggcagataacagcagcgcttcttt c" /GFF_Attribute="listShort" /listLong="swrC" /label="promotor_-10" upshifts 682223 /Source="Nicolas_upshifts" /id="U515" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.822177822177822" /psig="0.822177822177822" /xcortree=1398 /SigmaFactorBS="ccttaggcggctttccggcgagatcttCTTCTAtatttttca ttttgtTCATAGACATACCGATATAatattcacaggcagataacagcagcgcttcttt c" /GFF_Attribute="listShort" /listLong="swrC" /label="upshifts" S_feature complement(682401..682475) /Source="Nicolas_S_feature" /locus_tag="new_732824_732898_c" /HighExp="C30, S1, T3.0H, T4.0H, Salt, T5.0H, T2.0H, T3.30H, MG 150, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S238" promotor_-35 682453..682460 /Source="Nicolas_upshift_promotors" /id="U516" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.679320679320679" /psig="0.998001998001998" /xcortree=3014 /SigmaFactorBS="taatccttgaaaaatttagtaaaattttctggtatatgAGTT GACGttgttgcgttataacGTTTAGTATTATATAGAATGaccagtcagtcaataaaaa a" /listShort="swrC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(682469..682488) /Source="Nicolas_upshift_promotors" /id="U517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=3036 /SigmaFactorBS="acgtggttcatcatatcctccattacatttttTATTGACTga ctggtcattctaTATAATACTAAACGTTATAAcgcaacaacgtcaactcatataccag a" /listShort="S238, yerO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 682475 /Source="Nicolas_upshifts" /id="U516" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.679320679320679" /psig="0.998001998001998" /xcortree=3014 /SigmaFactorBS="taatccttgaaaaatttagtaaaattttctggtatatgAGTT GACGttgttgcgttataacGTTTAGTATTATATAGAATGaccagtcagtcaataaaaa a" /listShort="swrC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 682476..682495 /Source="Nicolas_upshift_promotors" /id="U516" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.679320679320679" /psig="0.998001998001998" /xcortree=3014 /SigmaFactorBS="taatccttgaaaaatttagtaaaattttctggtatatgAGTT GACGttgttgcgttataacGTTTAGTATTATATAGAATGaccagtcagtcaataaaaa a" /listShort="swrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(682482) /Source="Nicolas_upshifts" /id="U517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=3036 /SigmaFactorBS="acgtggttcatcatatcctccattacatttttTATTGACTga ctggtcattctaTATAATACTAAACGTTATAAcgcaacaacgtcaactcatataccag a" /listShort="S238, yerO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(682503..682510) /Source="Nicolas_upshift_promotors" /id="U517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=3036 /SigmaFactorBS="acgtggttcatcatatcctccattacatttttTATTGACTga ctggtcattctaTATAATACTAAACGTTATAAcgcaacaacgtcaactcatataccag a" /listShort="S238, yerO" /GFF_Attribute="listLong" /label="promotor_-35" CDS 682532..685690 /gene="srfP" /locus_tag="BSU_06710" /old_locus_tag="BSU06710" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11709341, 15066026, 15941986, 25366377" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11709341, 15066026, 15941986, 25366377; Product type t: transporter" /codon_start=1 /transl_table=11 /product="surfactin exporter involved in surfactin self-resistance" /protein_id="NP_388553.2" /db_xref="EnsemblGenomes-Gn:BSU06710" /db_xref="EnsemblGenomes-Tr:CAB12491" /db_xref="GOA:O31501" /db_xref="InterPro:IPR001036" /db_xref="InterPro:IPR027463" /db_xref="SubtiList:BG12842" /db_xref="UniProtKB/Swiss-Prot:O31501" /translation="MNHVINFVLKNKFAVWLMTIIVTAAGLYAGMNMKQESIPDVNMP YLTISTTYPGATPSQVADEVTKPVEQAVQNLDGVSVVTSTSYENASSVMIEYDYEKDM DKAKTEAAEALENVNLPDDAKDPEISRYSLNSFPILTLSVSSDKDNLQELTKQVEDSL VSKLEGIEGVASVQVSGQQVEEVEFSFKEDKLKEYGLDEDTVKQVIQGSDVTTPLGLY TFGNEEKSVVVSGDIETIKDLKNMRIPTASASSAGSSAASQAGAQSAQAAQSAQAAAQ VQQSASTAVPTVKLSDIATIKDVKKAESVSRTNGKDSIGINIVKANDANTVEVADDVK AELKKFKEDHKGFNYSATLDMAEPITQSVDTMLSKAIFGAIFAIVIILLFLRDIKSTL ISVVSIPLSLLIALLVLQQLDITLNIMTLGAMTVAIGRVVDDSIVVIENIYRRMRLKD EPLRGKALVREATKEMFKPIMSSTIVTIAVFLPLALVGGQIGELFIPFALTIVFALAA SLVISITLVPMLAHSLFKKSLTGAPIKAKEHKPGRLANIYKKVLNWALSHKWITSIIA VLMLLGSLFLVPLIGASYLPSEEEKTMQLTYSPEPGETKKEAENEAEKAEKILLDRKH VDTVQYSLGSGSPLAGGDSNGALFYIKYESDTPDFDKEKDNVLKEIQKQSDRGEWKSQ DFSSSGNNNELTYYVYGDSENDIKDTVKDIEKIMKDEKDLKNVNSGLSSTYDEYTFVA DQEKLSKLGLTASQISQALMSQTSQEPLTTVKKDGKELDVNIKTEKDEYKSVKDLENK KITSATGQEVKIGDVAKVKEGSTSDTVSKRDGKVYADVTGEVTSDNVTAVSAAIQKKI DKLDHPDNVSIDTGGVSADIADSFTKLGLAMLAAIAIVYLVLVITFGGALAPFAILFS LPFTVIGALVGLYVSGETISLNAMIGMLMLIGIVVTNAIVLIDRVIHKEAEGLSTREA LLEAGSTRLRPILMTAIATIGALIPLALGFEGGSQVISKGLGVTVIGGLISSTLLTLL IVPIVYEVLAKFRKKKPGTEEE*" /label="srfP CDS" gene 682532..685690 /gene="srfP" /locus_tag="BSU_06710" /old_locus_tag="BSU06710" /label="srfP gene" downshifts 685677 /Source="Nicolas_upshifts" /id="D333" /incds=0 /nref=76 /ntot=243 /MaxReadThrough="3.70478" /MaxDrop="4.6624" /score="-3.65521193" /energy="-12.7" /TU="U516" /idTUdmin="U516" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" promotor_-35 685929..685932 /Source="Nicolas_upshift_promotors" /id="U518" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.758241758241758" /psig="0.999000999001" /xcortree=2594 /SigmaFactorBS="tgtgcgttttcacctgtaagattatgtacattttGTTGcgat ttttttaactCATAGTATAATTAAAGGTTGttagtgtaaaaatggatcggatactctt a" /listShort="dagK, S239, yefA, S240, S241, yefC, S242, yeeA, yeeB, S243, yeeC, S244" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 685947..685966 /Source="Nicolas_upshift_promotors" /id="U518" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.758241758241758" /psig="0.999000999001" /xcortree=2594 /SigmaFactorBS="tgtgcgttttcacctgtaagattatgtacattttGTTGcgat ttttttaactCATAGTATAATTAAAGGTTGttagtgtaaaaatggatcggatactctt a" /listShort="dagK, S239, yefA, S240, S241, yefC, S242, yeeA, yeeB, S243, yeeC, S244" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 685955 /Source="Nicolas_upshifts" /id="U518" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.758241758241758" /psig="0.999000999001" /xcortree=2594 /SigmaFactorBS="tgtgcgttttcacctgtaagattatgtacattttGTTGcgat ttttttaactCATAGTATAATTAAAGGTTGttagtgtaaaaatggatcggatactctt a" /listShort="dagK, S239, yefA, S240, S241, yefC, S242, yeeA, yeeB, S243, yeeC, S244" /GFF_Attribute="listLong" /label="upshifts" CDS 686013..686924 /gene="dagK" /locus_tag="BSU_06720" /old_locus_tag="BSU06720" /EC_number="2.7.1.107" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10220166, 12682299, 17535816, 22224599, 24700682" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10220166, 12682299, 17535816, 22224599, 24700682; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="diacylglycerol kinase" /protein_id="NP_388554.1" /db_xref="EnsemblGenomes-Gn:BSU06720" /db_xref="EnsemblGenomes-Tr:CAB12492" /db_xref="GOA:O31502" /db_xref="InterPro:IPR001206" /db_xref="InterPro:IPR005218" /db_xref="InterPro:IPR016064" /db_xref="InterPro:IPR017438" /db_xref="SubtiList:BG12843" /db_xref="UniProtKB/Swiss-Prot:O31502" /translation="MKRARIIYNPTSGREIFKKHLAQVLQKFEQAGYETSTHATTCAG DATHAAKEAALREFDLIIAAGGDGTINEVVNGLAPLDNRPTLGVIPVGTTNDFARALG IPREDILKAADTVINGVARPIDIGQVNGQYFINIAGGGRLTELTYDVPSKLKTMLGQL AYYLKGMEMLPSLRPTEVEIEYDGKLFQGEIMLFLVTLTNSVGGFEKLAPDSSLNDGM FDLMILKKANLAEFIRVATMALRGEHINDQHIIYTKANRVKVNVSEKMQLNLDGEYGG MLPGEFVNLYRHIHVVMPKEKAEQLDD*" /label="dagK CDS" gene 686013..686924 /gene="dagK" /locus_tag="BSU_06720" /old_locus_tag="BSU06720" /label="dagK gene" S_feature 686925..687179 /Source="Nicolas_S_feature" /locus_tag="new_737348_737602" /HighExp="H2O2, Oxctl, Paraq, G180, Cold, C30, G150, G135, Heat, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S239" CDS 687180..688559 /gene="rlmCD" /locus_tag="BSU_06730" /old_locus_tag="BSU06730" /EC_number="2.1.1.189" /EC_number="2.1.1.190" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:21824914" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21824914; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methyltransferase of m5U747 and m5U1939 in 23S RNA" /protein_id="NP_388555.1" /db_xref="EnsemblGenomes-Gn:BSU06730" /db_xref="EnsemblGenomes-Tr:CAB12493" /db_xref="GOA:O31503" /db_xref="InterPro:IPR001566" /db_xref="InterPro:IPR002792" /db_xref="InterPro:IPR010280" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR029063" /db_xref="InterPro:IPR030390" /db_xref="InterPro:IPR030391" /db_xref="SubtiList:BG12826" /db_xref="UniProtKB/Swiss-Prot:O31503" /translation="MKMKPPVEKNEYYDVTFEDLTHEGAGVAKVQGFPIFVPNALPEE KAQIKVTRVKKGFAFGRLIELKEESPHRTDAPCPIYKQCGGCQLQHMTYEGQLLFKQK QVKDVLERIGKLDLSKVTVHPTLGMEDPWNYRNKAQVPVGEREGGLVAGFYQQRSHDI IDMSACLIQQSKNDEAVQAVKDICANYGVKAYNEERHKGWLRHIMVRYGVVTGEMMIV FITRTSDFPHKAKIIEDITAQFPHVKSIVQNINPNKTNVIFGNETNVIWGEEYIYDLI GDVKFAISARSFYQVNPEQTKVLYDKALEYAELQGEETVIDAYCGIGTISLFLAKQAK KVYGVEIVPEAIEDAKRNAELNGNTNAEFAVGEAETVIPKWYEEGITADTLVVDPPRK GCDEALLRTIVEMKPKRVVYVSCNPGTLARDLRVLEDGGYVTREVQPVDMFPHTNHVE CCVLIKLKE*" /label="rlmCD CDS" gene 687180..688559 /gene="rlmCD" /locus_tag="BSU_06730" /old_locus_tag="BSU06730" /label="rlmCD gene" S_feature 688560..689152 /Source="Nicolas_S_feature" /locus_tag="new_738983_739575" /HighExp="Cold, H2O2, G135, G150, Oxctl, G180, C30, Paraq, LPh, HPh" /AntisenseName="yefB" /AntisenseCor="0.24913678485492899" /AntisenseRegPval="-4.4000000000000004" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S240" CDS complement(688572..689474) /gene="yefB" /locus_tag="BSU_06740" /old_locus_tag="BSU06740" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 1779754, 1762151; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative site-specific recombinase / invertase; HGT island" /protein_id="NP_388556.1" /db_xref="EnsemblGenomes-Gn:BSU06740" /db_xref="EnsemblGenomes-Tr:CAB12494" /db_xref="GOA:O34574" /db_xref="InterPro:IPR011109" /db_xref="InterPro:IPR025827" /db_xref="SubtiList:BG12827" /db_xref="UniProtKB/Swiss-Prot:O34574" /translation="MYNEGVTSPSQLARKKNATDKWHGSSIRKILENPHYTGTLQQCR EYRPSVTSKRRRSVNLENQIIIEKSHEPIIPLEDFLIVQEILITRKRRRPQAEVHLFT NTAVCKDCRRSMHFKKNRKGYVCGSYNKHGLKACSDHYVSEIDLTDKVITNLNKIYLK FSKENYFKELSEKALKYKEKIESKIIEINEKLNDKKRDKSNLVISLANGVISKEDYQL AINITNEDISNFETTLHQLSKDLEFQKIEKEIIDFKKSLDKFMKEGTLTPEMLHLLVD EIEVHANGTIEINYRFREPTVPSA*" /label="yefB CDS" gene complement(688572..689474) /gene="yefB" /locus_tag="BSU_06740" /old_locus_tag="BSU06740" /label="yefB gene" downshifts 689109 /Source="Nicolas_upshifts" /id="D334" /incds=1 /nref=1 /ntot=30 /MaxReadThrough="4.70474" /MaxDrop="2.82299" /score="-8.81916201" /energy="-8.8" /TU="U518" /idTUdmin="U516" /TUdmin=3322 /isTUend="FALSE" /label="downshifts" S_feature 689154..689454 /Source="Nicolas_S_feature" /locus_tag="new_739577_739877" /HighExp="H2O2, Cold, G180, G135, G150, Paraq, Oxctl, C30, LPh, LBGexp" /AntisenseName="yefB" /AntisenseCor="0.202214664414261" /AntisenseRegPval="-3.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S241" CDS 689455..689790 /gene="yefC" /locus_tag="BSU_06750" /old_locus_tag="BSU06750" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative resolvase; HGT island" /protein_id="NP_388557.2" /db_xref="EnsemblGenomes-Gn:BSU06750" /db_xref="EnsemblGenomes-Tr:CAB12495" /db_xref="GOA:O35034" /db_xref="InterPro:IPR006119" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036162" /db_xref="SubtiList:BG12828" /db_xref="UniProtKB/Swiss-Prot:O35034" /translation="MTPSLYNPLAIASKPFPAIYSEKILIFTIFSAFAEFERDMIVER TQEGKMLAKQNPDFREGRPKKFTKQQINHALTLLENHSYKQVEDMTGISVSTLVRAKK KKAAEAING*" /label="yefC CDS" gene 689455..689790 /gene="yefC" /locus_tag="BSU_06750" /old_locus_tag="BSU06750" /label="yefC gene" S_feature 689791..689864 /Source="Nicolas_S_feature" /locus_tag="new_740214_740287" /HighExp="G180, H2O2, G150, Cold, G135, Paraq, Oxctl, C30, LPh, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S242" CDS 689865..692504 /gene="yeeA" /locus_tag="BSU_06760" /old_locus_tag="BSU06760" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative restriction type II methylase; HGT island" /protein_id="NP_388558.1" /db_xref="EnsemblGenomes-Gn:BSU06760" /db_xref="EnsemblGenomes-Tr:CAB12496" /db_xref="GOA:O31504" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG12818" /db_xref="UniProtKB/Swiss-Prot:O31504" /translation="MALIDLEDKIAEIVNREDHSDFLYELLGVYDVPRATITRLKKGN QNLTKRVGEVHLKNKVWFKEAKKGKLFDALIDIEQQVEYLSAKPRYLLVTDYDGVLAK DTKTLEALDVKFEELPQYFDFFLAWKGIEKVEFEKENPADIKAAERFARIYDVLRKEN NIIETNRGLDLFLIRLLFCFFAEDTDIFKRNSFTNLIKTLTEEDGSNLNKLFADLFIV LDKNERDDVPSYLKEFPYVNGQLFTEPHTELEFSAKSRKLIIECGELLNWAKINPDIF GSMIQAVASEESRSYLGMHYTSVPNIMKVIKPLFLDKLNQSFLDAYDDYTKLENLLTR IGKIKFFDPACGSGNFLIITYKELRRMEINIIKRLQELLGEYLYVPSVTLSQFYGIEI EDFAHDVAKLSLWIAEHQMNEELKNEVHNAVRPTLPLHTAGDIRCANAIRVEWTEVCP AQGSEEVYVFGNPPYLGSKKQNKEHKSDMLSIFGKVKNGKMLDYISAWFYFGAKYAST TNAKVAFVSTNSVTQGEQVSILWNELFKFGIQINFAYKSFKWANNAKNNAAVIVVIVG FGPLDTKVNKYLFVDETKKLVSNISPYLTDGENILVSSRTKPISDLPKLHFGNMPNDG GGLLFTITEYTDAINKYPELVPYFKKFIGSVEFINGGLRYCLWLNEAKYEKIKSNPLI QERISISKNHREKSTDKGTNKLALTPWKFRDTHETTNYSIVVPSVSSENRFYIPMGLA GADTILSNLIYVIYDAEIYLLGILMSRMHMTWVKAVAGRLKTDYRYSAGLCYNTFPIP ELSTRRKNEIEEAILEILDLREEQGGTLAELYNPSTMPIELKVAHEKLDGIVERAYRQ KQFESDEERLEVLLKLYQEMTER*" /label="yeeA CDS" gene 689865..692504 /gene="yeeA" /locus_tag="BSU_06760" /old_locus_tag="BSU06760" /label="yeeA gene" CDS 692516..694315 /gene="yeeB" /locus_tag="BSU_06770" /old_locus_tag="BSU06770" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative DNA helicase / endonuclease; HGT island" /protein_id="NP_388559.2" /db_xref="EnsemblGenomes-Gn:BSU06770" /db_xref="EnsemblGenomes-Tr:CAB12497" /db_xref="GOA:O34469" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12819" /db_xref="UniProtKB/Swiss-Prot:O34469" /translation="MENIIEINYNQTGKSKKTNEYGMREMQARAFEKRNSQYLLVKAP PASGKSRALMFIGLDKLINQGLRKVIVAVPERSIGSSFKNTDLKSYGFFENWKVDPRN NLTVGGDNSKVKSFVRFMESDDQVLICTHSTLRFAFEKIDDKAFDNCLLAIDEFHHVS ADVNSRLGELLRSIIHNSSAHIVAMTGSYFRGDSVPILLPEDEELFDKVTYSYYEQLD GYEYLKGFGIGYHFYQGQYTSAINEVLDTNKKTIVHIPNVNSGESTKDKYDEVGKILD MIGEVEYQDDDTGIIYVKRHSDGKTLKIADLVDDQVGRENVVAYLRNIEALDDLDIII ALGMAKEGFDWPFCEHTLTVGYRGSLTEIVQIIGRCTRDSYNKTYAQFTNLIAMPDAK DEVVTYTVNTMLKAISASLLMEQVLTPDFKFKRRRNESEKSSTTGELFVKGLKEPSTE NVKKIIENDINDLKAKIMQDSQVQKTFSGEVDPKVLNKVLIPKVIQKVYPNLSDEEIE EVRQHVVLDTVMKGAKSEVVGSKEFIRMADKFINIEDLDINLIDSINPFQKAFEVLSK ELNSPVLKLIQETIDAKRINFDEDELVFIWPKV*" /label="yeeB CDS" gene 692516..694315 /gene="yeeB" /locus_tag="BSU_06770" /old_locus_tag="BSU06770" /label="yeeB gene" promotor_-10 complement(692756..692771) /Source="Nicolas_upshift_promotors" /id="U519" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1689 /SigmaFactorBS="cagttaaattatttctaggatcaactttccaattttcaaAGA AACCATAactttttaaatCCGTATTTTTAAATGAagaacctatagagcgttcaggtac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(692771) /Source="Nicolas_upshifts" /id="U519" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1689 /SigmaFactorBS="cagttaaattatttctaggatcaactttccaattttcaaAGA AACCATAactttttaaatCCGTATTTTTAAATGAagaacctatagagcgttcaggtac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(692783..692792) /Source="Nicolas_upshift_promotors" /id="U519" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1689 /SigmaFactorBS="cagttaaattatttctaggatcaactttccaattttcaaAGA AACCATAactttttaaatCCGTATTTTTAAATGAagaacctatagagcgttcaggtac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 694316..694427 /Source="Nicolas_S_feature" /locus_tag="new_744739_744850" /HighExp="Cold, G180, G135, G150, H2O2, Paraq, HPh, LPh, Oxctl, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S243" CDS 694428..695576 /gene="yeeC" /locus_tag="BSU_06780" /old_locus_tag="BSU06780" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; HGT island" /protein_id="NP_388560.2" /db_xref="EnsemblGenomes-Gn:BSU06780" /db_xref="EnsemblGenomes-Tr:CAB12498" /db_xref="InterPro:IPR018306" /db_xref="SubtiList:BG12820" /db_xref="UniProtKB/Swiss-Prot:O34352" /translation="MASNRYHSINEIMESQLFYQITTPPKKTQKAQYDPEVEKFLEII EFVKENGREPQKVPTDLTERSLASRLIGIRKDPDRMEYLKEYDEIGLLEVRSKELTIP KISSIDDILKSGLSALLGDNLNNDITRSIFDTSSLQKVTTMPEYVAKRKKIKDFGKFE ELFKKCHKEITEGKRKILTFKNEQDIQSNSFYILKGVLLYVEDVGERKKAKGKTNARL RCIFENGTESDMLLRSLSAELYKHGRRVTDNEDTLLDNVREDDVSTGFIYVLKSLSTD PQISSIKNLYKIGFTTGSVENRIRNAENQSTYLYAPVEIVTTYQVFNMNASKFETAIH HALANNNLDVSILGANGKMLVPKEWFVVTLEDLQAVIDEIVMMVHLYD*" /label="yeeC CDS" gene 694428..695576 /gene="yeeC" /locus_tag="BSU_06780" /old_locus_tag="BSU06780" /label="yeeC gene" S_feature 695577..696766 /Source="Nicolas_S_feature" /locus_tag="new_746000_747189" /HighExp="Cold, G135, H2O2, G180, G150, LPh, C30, HPh, BMM, Paraq" /AntisenseName="yeeD" /AntisenseCor="-0.41772847620445203" /AntisenseRegPval="-12.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S244" CDS complement(695838..696143) /gene="yeeD" /locus_tag="BSU_06790" /old_locus_tag="BSU06790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; HGT island" /protein_id="NP_388561.1" /db_xref="EnsemblGenomes-Gn:BSU06790" /db_xref="EnsemblGenomes-Tr:CAB12499" /db_xref="SubtiList:BG12821" /db_xref="UniProtKB/Swiss-Prot:O34950" /translation="MTVRKELIKQINLTITVIKTINQKNPTPMVKNILKRYEEAKEFI LQSSDGKFEEDLSKVRNKLDTLTRAYLESANDYMNPMLKEMHKTEKLLKEYDETTQS* " /label="yeeD CDS" gene complement(695838..696143) /gene="yeeD" /locus_tag="BSU_06790" /old_locus_tag="BSU06790" /label="yeeD gene" CDS complement(696210..696416) /gene="yezA" /locus_tag="BSU_06800" /old_locus_tag="BSU06800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="hypothetical protein; HGT island" /protein_id="NP_388562.1" /db_xref="EnsemblGenomes-Gn:BSU06800" /db_xref="EnsemblGenomes-Tr:CAB12500" /db_xref="GOA:O31505" /db_xref="InterPro:IPR000290" /db_xref="InterPro:IPR035900" /db_xref="SubtiList:BG12872" /db_xref="UniProtKB/Swiss-Prot:O31505" /translation="MDKLTKEELIFLVKELMNPTLDDEKVSEYLDLLEKNVPYPAPSD LIFWSNEDYTAEQVVKIALNYKDE*" /label="yezA CDS" gene complement(696210..696416) /gene="yezA" /locus_tag="BSU_06800" /old_locus_tag="BSU06800" /label="yezA gene" CDS complement(696656..697111) /gene="yezG" /locus_tag="BSU_06811" /old_locus_tag="BSU06811" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; HGT island" /protein_id="YP_003097692.1" /db_xref="EnsemblGenomes-Gn:BSU06811" /db_xref="EnsemblGenomes-Tr:CAX52579" /db_xref="InterPro:IPR006728" /db_xref="InterPro:IPR036170" /db_xref="UniProtKB/Swiss-Prot:C0H3X4" /translation="MQDLYQLIGEKLNDIIPGEWTKIYLYAEVLDDSTMVLFHFRTPE NNQIIYSQDIPSHYNVSKDIFKTLLRELRELFEELRTEHRNNNDDVWTNLTLTLDRSG EFQLDYNYDDILASELDGYERIAIWEYKNLGILPEDEDDKEFVISYLGL*" /label="yezG CDS" gene complement(696656..697111) /gene="yezG" /locus_tag="BSU_06811" /old_locus_tag="BSU06811" /label="yezG gene" downshifts complement(696669) /Source="Nicolas_upshifts" /id="D335" /incds=0 /nref=41 /ntot=213 /MaxReadThrough="4.42275" /MaxDrop="5.23695" /score="10.2582155" /energy="-11.7" /TU="U520,U521" /idTUdmin="U520" /TUdmin="-529" /isTUend="FALSE" /label="downshifts" CDS complement(697131..699140) /gene="yeeF" /locus_tag="BSU_06812" /old_locus_tag="BSU06812" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative nucleic acid binding protein; HGT island" /protein_id="NP_388563.2" /db_xref="EnsemblGenomes-Gn:BSU06812" /db_xref="EnsemblGenomes-Tr:CAB12501" /db_xref="GOA:O31506" /db_xref="InterPro:IPR006829" /db_xref="SubtiList:BG12822" /db_xref="UniProtKB/Swiss-Prot:O31506" /translation="MKVFEAKTLLSEATDRAKEYKELRTQMVNLRKALKGVADLSDSE FSGKGASNIKAFYHDHVGVADQWIDYIDMKIAFFNSIAGAAEDKGLSDAYIEESFLEH ELANANKKSKSIMSEQKKAMKDILNDIDDILPLDLFSTETFKDELADANDKRKKTLEK LDALDEDLKTEYALSEPNEQFIKSDFQKLQEATGKGKNATPIHYNAKAYRESDIHKKK GDIEKRTEAYLKIKKEEAKEREIEKLKERLKNYDYADADEFYEMAKTIGYENLTAEQQ RYFTQIENTRELEAGFKGVAVGLYDSGKDAVVGLWDMVTDPGGTVEAITGAMAHPIKT YEAISAAIEESYQKDMVNGDTYSRARWVSYAVGTVVTSIVGTKGVGAVSKTGTAAKVT TKVKTAASKSATAQKAITVSKQTVDHIKQKVNTGIEVSKKHVKTKLNQIGDLTLADIL PYHPRHDLVPAGVPYNAVNGVTLKEGLQKFAKVILPKPYGTSSSGRRTPAPHVPPVTV KYGEHFARWSRKKVLKPNIIYKTKEGYTYTTDNYGRITSVKADLQLGEAKRNQYAQTN AGKPQDRKPDDDGGHLIATQFKGSGQFDNIVPMNSQINRSGGKWYEMEQEWAKALSKK PPKKVAVQIEPVYSGDSLRPSYFDVTYKIGSRKEISVSIKNQPGG*" /label="yeeF CDS" gene complement(697131..699140) /gene="yeeF" /locus_tag="BSU_06812" /old_locus_tag="BSU06812" /label="yeeF gene" promotor_-10 complement(697498..697517) /Source="Nicolas_upshift_promotors" /id="U520" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig="0.999000999001" /xcortree=2752 /SigmaFactorBS="aatatcatctacaaaacaaaagaaggctacACGTACacgact gacaacTATGGTAGAATTACAAGTGTcaaagcagacttgcagctgggagaagcgaaac g" /listShort="yezG, yezA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(697505) /Source="Nicolas_upshifts" /id="U520" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig="0.999000999001" /xcortree=2752 /SigmaFactorBS="aatatcatctacaaaacaaaagaaggctacACGTACacgact gacaacTATGGTAGAATTACAAGTGTcaaagcagacttgcagctgggagaagcgaaac g" /listShort="yezG, yezA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(697530..697535) /Source="Nicolas_upshift_promotors" /id="U520" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig="0.999000999001" /xcortree=2752 /SigmaFactorBS="aatatcatctacaaaacaaaagaaggctacACGTACacgact gacaacTATGGTAGAATTACAAGTGTcaaagcagacttgcagctgggagaagcgaaac g" /listShort="yezG, yezA" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(699167..699186) /Source="Nicolas_upshift_promotors" /id="U521" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig="0.994005994005994" /xcortree=2985 /SigmaFactorBS="atgactcatttttccaccaaaacacgttctcacccccacctt atcccgaccCGTGGTAAAATTTTGATATTgagcgaacaaaagaagggaaatggtcatg a" /listShort="yeeF, yezG, yezA, yeeD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(699177) /Source="Nicolas_upshifts" /id="U521" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig="0.994005994005994" /xcortree=2985 /SigmaFactorBS="atgactcatttttccaccaaaacacgttctcacccccacctt atcccgaccCGTGGTAAAATTTTGATATTgagcgaacaaaagaagggaaatggtcatg a" /listShort="yeeF, yezG, yezA, yeeD" /GFF_Attribute="listLong" /label="upshifts" CDS 699352..700374 /gene="yeeG" /locus_tag="BSU_06820" /old_locus_tag="BSU06820" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative phage receptor protein" /protein_id="NP_388564.2" /db_xref="EnsemblGenomes-Gn:BSU06820" /db_xref="EnsemblGenomes-Tr:CAB12502" /db_xref="GOA:O31507" /db_xref="InterPro:IPR015943" /db_xref="SubtiList:BG12823" /db_xref="UniProtKB/Swiss-Prot:O31507" /translation="MTKKRITFGLLVLMVCVILFVLYVQLRNKDSIPVQSSAIHPEED RIFFIYSNPFIKESVLLSTSTGERFNRRTFKVADVPYIQTKSYASTDLVLLAEHEPFY YTLEKDVIKEHPLSDPFAFWYEGKDVTIEAYNVDTTGNEIHINDRKTKKEYTLTLPPL VTMGASDENFIYIIQSMSIYVIDRKTEEMIETLSLASYADQFADSEEFIVASSDHKLT VIEKGTWKTTYIAYPEDLEYADTVYYDKESGSFYVAYEDKEGGANLLEYGEDFSIHTY SLKFPYMEAKFKGNLLYIVAQEEHKKGIGGYVGVFDIHSKEMLYQFDLPEEQVKVQDF VVVDNK*" /label="yeeG CDS" gene 699352..700374 /gene="yeeG" /locus_tag="BSU_06820" /old_locus_tag="BSU06820" /label="yeeG gene" promotor_-35 700474..700481 /Source="Nicolas_upshift_promotors" /id="U522" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.466533466533467" /psig="0.997002997002997" /xcortree=2961 /SigmaFactorBS="caaattgacaggatgaaaaaacaatttcttccttctatATTG TTTTcaaaatttgggatTGATAGAATATGACATATCTcatagagaaggagggaagccg t" /listShort="rapH, phrH, S245, yeeI" /listLong="yeeK" /label="promotor_-35" promotor_-10 700495..700514 /Source="Nicolas_upshift_promotors" /id="U522" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.466533466533467" /psig="0.997002997002997" /xcortree=2961 /SigmaFactorBS="caaattgacaggatgaaaaaacaatttcttccttctatATTG TTTTcaaaatttgggatTGATAGAATATGACATATCTcatagagaaggagggaagccg t" /listShort="rapH, phrH, S245, yeeI" /listLong="yeeK" /label="promotor_-10" upshifts 700496 /Source="Nicolas_upshifts" /id="U522" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.466533466533467" /psig="0.997002997002997" /xcortree=2961 /SigmaFactorBS="caaattgacaggatgaaaaaacaatttcttccttctatATTG TTTTcaaaatttgggatTGATAGAATATGACATATCTcatagagaaggagggaagccg t" /listShort="rapH, phrH, S245, yeeI" /listLong="yeeK" /label="upshifts" CDS 700536..701666 /gene="rapH" /locus_tag="BSU_06830" /old_locus_tag="BSU06830" /EC_number="3.1.-.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16553878, 21908671" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16553878, 21908671; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="response regulator aspartate phosphatase" /protein_id="NP_388565.2" /db_xref="EnsemblGenomes-Gn:BSU06830" /db_xref="EnsemblGenomes-Tr:CAB12503" /db_xref="GOA:Q59HN8" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="PDB:3Q15" /db_xref="SubtiList:BG11031" /db_xref="UniProtKB/Swiss-Prot:Q59HN8" /translation="MSQAIPSSRVGVKINEWYKMIRQFSVPDAEILKAEVEQDIQQME EDQDLLIYYSLMCFRHQLMLDYLEPGKTYGNRPTVTELLETIETPQKKLTGLLKYYSL FFRGMYEFDQKEYVEAIGYYREAEKELPFVSDDIEKAEFHFKVAEAYYHMKQTHVSMY HILQALDIYQNHPLYSIRTIQSLFVIAGNYDDFKHYDKALPHLEAALELAMDIQNDRF IAISLLNIANSYDRSGDDQMAVEHFQKAAKVSREKVPDLLPKVLFGLSWTLCKAGQTQ KAFQFIEEGLDHITARSHKFYKELFLFLQAVYKETVDERKIHDLLSYFEKKNLHAYIE ACARSAAAVFESSCHFEQAAAFYRKVLKAQEDILKGECLYAY*" /label="rapH CDS" gene 700536..701666 /gene="rapH" /locus_tag="BSU_06830" /old_locus_tag="BSU06830" /label="rapH gene" CDS 701656..701829 /gene="phrH" /locus_tag="BSU_06839" /old_locus_tag="BSU06839" /experiment="publication(s) with functional evidences, PMID:16553878, 21908671" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16553878, 21908671; Product type r: regulator" /codon_start=1 /transl_table=11 /product="hexapeptide (TDRNTT) inhibitor of regulatory cascade" /protein_id="YP_003097693.1" /db_xref="EnsemblGenomes-Gn:BSU06839" /db_xref="EnsemblGenomes-Tr:CAX52580" /db_xref="GOA:Q59HN7" /db_xref="UniProtKB/Swiss-Prot:Q59HN7" /translation="MPIKKKVMMCLAVTLVFGSMSFPTLTNSGGFKESTDRNTTYIDH SPYKLSDQKKALS*" /label="phrH CDS" gene 701656..701829 /gene="phrH" /locus_tag="BSU_06839" /old_locus_tag="BSU06839" /label="phrH gene" downshifts 701784 /Source="Nicolas_upshifts" /id="D336" /incds=0 /nref=3 /ntot=66 /MaxReadThrough="5.5891" /MaxDrop="2.9063" /score="14.5772672" /energy="-7.6" /TU="U522" /idTUdmin="U522" /TUdmin="-901" /isTUend="FALSE" /label="downshifts" S_feature 701830..701934 /Source="Nicolas_S_feature" /locus_tag="new_752253_752357" /HighExp="S2, G/S, T2.30H, GM 150, T3.0H, T2.0H, S1, T-4.40H, T-2.40H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S245" promotor_-35 701901..701908 /Source="Nicolas_upshift_promotors" /id="U523" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig="0.999000999001" /xcortree=1934 /SigmaFactorBS="cattccttctatttctaacgcaagaCACTCGAAacaaccaaa ccattTGAGGTATAATGGATAAAGTgaataacagtatttagattgatatatatgaaag a" /listShort="yeeI, yeeK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 701923..701942 /Source="Nicolas_upshift_promotors" /id="U523" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig="0.999000999001" /xcortree=1934 /SigmaFactorBS="cattccttctatttctaacgcaagaCACTCGAAacaaccaaa ccattTGAGGTATAATGGATAAAGTgaataacagtatttagattgatatatatgaaag a" /listShort="yeeI, yeeK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 701936 /Source="Nicolas_upshifts" /id="U523" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig="0.999000999001" /xcortree=1934 /SigmaFactorBS="cattccttctatttctaacgcaagaCACTCGAAacaaccaaa ccattTGAGGTATAATGGATAAAGTgaataacagtatttagattgatatatatgaaag a" /listShort="yeeI, yeeK" /GFF_Attribute="listLong" /label="upshifts" CDS 701989..702708 /gene="yeeI" /locus_tag="BSU_06840" /old_locus_tag="BSU06840" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative DNA integrase or transcriptional regulator" /protein_id="NP_388566.3" /db_xref="EnsemblGenomes-Gn:BSU06840" /db_xref="EnsemblGenomes-Tr:CAB12504" /db_xref="GOA:O31509" /db_xref="InterPro:IPR002876" /db_xref="InterPro:IPR017856" /db_xref="InterPro:IPR026562" /db_xref="InterPro:IPR026564" /db_xref="InterPro:IPR029072" /db_xref="SubtiList:BG12824" /db_xref="UniProtKB/Swiss-Prot:O31509" /translation="MGRKWNNIKEKKASKDANTSRIYAKFGREIYVAAKQGEPDPESN QALKVVLERAKTYSVPKNIIERAIEKAKGGAEENYDELRYEGFGPNGSMIIVDALTNN VNRTAPEVRAAFGKNGGNMGVSGSVAYMFDATAVIGVEGKTADEALEILMEADVDVRD ILEEDDSAIVYAEPDQFHAVQEAFKNAGVEEFTVAELTMLAQSEVTLPDDAKEQFEKL IDALEDLEDVQQVYHNVDLGE*" /label="yeeI CDS" gene 701989..702708 /gene="yeeI" /locus_tag="BSU_06840" /old_locus_tag="BSU06840" /label="yeeI gene" downshifts complement(701991) /Source="Nicolas_upshifts" /id="D337" /incds=0 /nref=3 /ntot=70 /MaxReadThrough="1.42969" /MaxDrop="3.99424" /score="-5.23712559" /energy="-7.6" /TU="NA" /idTUdmin="U520" /TUdmin="-5851" /isTUend="FALSE" /label="downshifts" promotor_-35 702566..702573 /Source="Nicolas_upshift_promotors" /id="U524" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.844155844155844" /psig="0.903096903096903" /xcortree=3101 /SigmaFactorBS="gtttaaaaacgcgggtgtcgaggaatttaCAGTAGCGgagct gacaatgcTTGCGCAAAGTGAAGTAACGcttccggatgatgcaaaggaacagtttgaa a" /listShort="yeeK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 702587..702606 /Source="Nicolas_upshift_promotors" /id="U524" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.844155844155844" /psig="0.903096903096903" /xcortree=3101 /SigmaFactorBS="gtttaaaaacgcgggtgtcgaggaatttaCAGTAGCGgagct gacaatgcTTGCGCAAAGTGAAGTAACGcttccggatgatgcaaaggaacagtttgaa a" /listShort="yeeK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 702597 /Source="Nicolas_upshifts" /id="U524" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.844155844155844" /psig="0.903096903096903" /xcortree=3101 /SigmaFactorBS="gtttaaaaacgcgggtgtcgaggaatttaCAGTAGCGgagct gacaatgcTTGCGCAAAGTGAAGTAACGcttccggatgatgcaaaggaacagtttgaa a" /listShort="yeeK" /GFF_Attribute="listLong" /label="upshifts" downshifts 702690 /Source="Nicolas_upshifts" /id="D338" /incds=0 /nref=223 /ntot=271 /MaxReadThrough="4.94236" /MaxDrop="5.19148" /score="31.0415099" /energy="-11.4" /TU="U523,U524" /idTUdmin="U522" /TUdmin=5 /isTUend="TRUE" /label="downshifts" promotor_-35 702777..702786 /Source="Nicolas_upshift_promotors" /id="U525" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1279 /SigmaFactorBS="tcccggaaattgttttagctgtatgtaggcggccGCCTATAC GAtctataagatattCTCATACTCTGGACTGTAACctatgtgaaggagagagtaaata t" /listShort="yeeK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 702800..702819 /Source="Nicolas_upshift_promotors" /id="U525" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1279 /SigmaFactorBS="tcccggaaattgttttagctgtatgtaggcggccGCCTATAC GAtctataagatattCTCATACTCTGGACTGTAACctatgtgaaggagagagtaaata t" /listShort="yeeK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 702803 /Source="Nicolas_upshifts" /id="U525" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1279 /SigmaFactorBS="tcccggaaattgttttagctgtatgtaggcggccGCCTATAC GAtctataagatattCTCATACTCTGGACTGTAACctatgtgaaggagagagtaaata t" /listShort="yeeK" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(702807..702825) /Source="Nicolas_upshift_promotors" /id="U526" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.935064935064935" /psig="0.935064935064935" /xcortree=1214 /SigmaFactorBS="aatgaccaaaaccaggtccgccatacatatgtcttgtatcaG TCATAtttactctctccttcACATAGGTTACAGTCCAGAgtatgagaatatcttatag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(702827) /Source="Nicolas_upshifts" /id="U526" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.935064935064935" /psig="0.935064935064935" /xcortree=1214 /SigmaFactorBS="aatgaccaaaaccaggtccgccatacatatgtcttgtatcaG TCATAtttactctctccttcACATAGGTTACAGTCCAGAgtatgagaatatcttatag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(702841..702846) /Source="Nicolas_upshift_promotors" /id="U526" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.935064935064935" /psig="0.935064935064935" /xcortree=1214 /SigmaFactorBS="aatgaccaaaaccaggtccgccatacatatgtcttgtatcaG TCATAtttactctctccttcACATAGGTTACAGTCCAGAgtatgagaatatcttatag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 702842..703279 /gene="cotK" /locus_tag="BSU_06850" /old_locus_tag="BSU06850" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10714992, 19060142, 19933362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10714992, 19060142, 19933362; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore inner coat protein" /protein_id="NP_388567.2" /db_xref="EnsemblGenomes-Gn:BSU06850" /db_xref="EnsemblGenomes-Tr:CAB12505" /db_xref="GOA:O31510" /db_xref="SubtiList:BG12825" /db_xref="UniProtKB/Swiss-Prot:O31510" /translation="MTDTRHMYGGPGFGHYQGFGIGHPGYGMQSTGYPGYGMYGGHPG YGMQGYPDHGIHGGVGGYPGYGGYGGYPSGGYGGSPGTGSYPSMHHENDGHHHYYHHH HDGKDNLHHHHHHVGKDNHHHHHDGHYGHHHHHMGHWGKDGYK*" /label="cotK CDS" gene 702842..703279 /gene="cotK" /locus_tag="BSU_06850" /old_locus_tag="BSU06850" /label="cotK gene" downshifts complement(702849) /Source="Nicolas_upshifts" /id="D339" /incds=0 /nref=1 /ntot=4 /MaxReadThrough="1.62645" /MaxDrop="3.26146" /score="-5.23712559" /energy="-7.6" /TU="NA" /idTUdmin="U520" /TUdmin="-6709" /isTUend="FALSE" /label="downshifts" downshifts 703279 /Source="Nicolas_upshifts" /id="D340" /incds=0 /nref=82 /ntot=208 /MaxReadThrough="2.37564" /MaxDrop="8.21113" /score="17.7046271" /energy="-9" /TU="U525" /idTUdmin="U523" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 703339..703346 /Source="Nicolas_upshift_promotors" /id="U527" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.938061938061938" /psig="0.999000999001" /xcortree=2200 /SigmaFactorBS="cttgcagatcaagagtgtttttttagctttttTCTTGACTgt tcagtctggaaaaTGGTAACATTTGTTTCAGGAggtgatcattttttggggaggaata a" /listShort="yezE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 703362..703381 /Source="Nicolas_upshift_promotors" /id="U527" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.938061938061938" /psig="0.999000999001" /xcortree=2200 /SigmaFactorBS="cttgcagatcaagagtgtttttttagctttttTCTTGACTgt tcagtctggaaaaTGGTAACATTTGTTTCAGGAggtgatcattttttggggaggaata a" /listShort="yezE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 703367 /Source="Nicolas_upshifts" /id="U527" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.938061938061938" /psig="0.999000999001" /xcortree=2200 /SigmaFactorBS="cttgcagatcaagagtgtttttttagctttttTCTTGACTgt tcagtctggaaaaTGGTAACATTTGTTTCAGGAggtgatcattttttggggaggaata a" /listShort="yezE" /GFF_Attribute="listLong" /label="upshifts" CDS 703394..703978 /gene="yezE" /locus_tag="BSU_06860" /old_locus_tag="BSU06860" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (TetR family)" /protein_id="YP_054572.1" /db_xref="EnsemblGenomes-Gn:BSU06860" /db_xref="EnsemblGenomes-Tr:CAE01448" /db_xref="GOA:Q7WY76" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036271" /db_xref="SubtiList:BG14194" /db_xref="UniProtKB/Swiss-Prot:Q7WY76" /translation="MGRNKEFDTALVLHRAIEVFGEYGYEGTSLQDLLSHLGIARQSL YDTYGTKRDLFLSAVKSYLEGKNAAVMERLEAPGSVKEAIRDIFQEGVNALRDPERAK ACYIINSAIEQIPHDPELARYFERQSKQLEDAFYHGLLRAKDQGELNGEDTDISALAR YLNQSRLSLTFIAKVTADMDRLQDHVDVSLSVLD*" /label="yezE CDS" gene 703394..703978 /gene="yezE" /locus_tag="BSU_06860" /old_locus_tag="BSU06860" /label="yezE gene" downshifts 703959 /Source="Nicolas_upshifts" /id="D341" /incds=0 /nref=26 /ntot=216 /MaxReadThrough="2.43615" /MaxDrop="3.31193" /score="17.7046271" /energy="-9" /TU="NA" /idTUdmin="U527" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS 704057..704500 /gene="yesE" /locus_tag="BSU_06870" /old_locus_tag="BSU06870" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388568.1" /db_xref="EnsemblGenomes-Gn:BSU06870" /db_xref="EnsemblGenomes-Tr:CAB12506" /db_xref="InterPro:IPR009959" /db_xref="InterPro:IPR032710" /db_xref="PDB:1S5A" /db_xref="SubtiList:BG12844" /db_xref="UniProtKB/Swiss-Prot:O31511" /translation="MLMNEFEKACETLRKFMAYMLEKDMKSWTELWDENAVFEFPYAP EGSPKRIEGKAAIYDYIKDYPKQIHLSSFTAPTVYRSADSNTVIAEFQCDGHVIETGL PYRQSYISVIETRDGRIVRYRDYWNPLVVKEAFGGSFLQTEESGK*" /label="yesE CDS" gene 704057..704500 /gene="yesE" /locus_tag="BSU_06870" /old_locus_tag="BSU06870" /label="yesE gene" CDS 704497..705357 /gene="yesF" /locus_tag="BSU_06880" /old_locus_tag="BSU06880" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 21494745; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388569.1" /db_xref="EnsemblGenomes-Gn:BSU06880" /db_xref="EnsemblGenomes-Tr:CAB12507" /db_xref="GOA:O31512" /db_xref="InterPro:IPR001509" /db_xref="InterPro:IPR008030" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11808" /db_xref="UniProtKB/Swiss-Prot:O31512" /translation="MMKQNPILITGGTGTVGSRIASRLIKLGYRVRIASRKKGALADA EYVYFNWKYASSFTPALEQVKQIYLVAPVGVFDPAPYVLPFLKEAKRLGAKRVVMQSA SVVSENGPVFGALHQAVREFPEWTVLRPSYFMQNFINVQHRMSIQTEGRITTASGEGK LGFIDADDIAETAVRALIDDVPHQTHHILTGPEALSYAEAAEIIGAAAGRRVEHVSIS RSELQHKMEAGGLPADYAHFMAKLDEAISHGAEHRVTDTVKRVTGKEPRSLSEFAAAH AAYWTSFWTE*" /label="yesF CDS" gene 704497..705357 /gene="yesF" /locus_tag="BSU_06880" /old_locus_tag="BSU06880" /label="yesF gene" promotor_-35 705419..705424 /Source="Nicolas_upshift_promotors" /id="U528" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1097 /SigmaFactorBS="ccgaaggtcttcttattgaaaaagctaagtcgtgttttaGTC ATAatcatgcctcctgccTCATACCTATTAAGGTCATtgtttttgagaaaggaggagc c" /listShort="cotJA, cotJB, cotJC, S246, yesJ, yesK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 705440..705458 /Source="Nicolas_upshift_promotors" /id="U528" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1097 /SigmaFactorBS="ccgaaggtcttcttattgaaaaagctaagtcgtgttttaGTC ATAatcatgcctcctgccTCATACCTATTAAGGTCATtgtttttgagaaaggaggagc c" /listShort="cotJA, cotJB, cotJC, S246, yesJ, yesK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 705440 /Source="Nicolas_upshifts" /id="U528" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1097 /SigmaFactorBS="ccgaaggtcttcttattgaaaaagctaagtcgtgttttaGTC ATAatcatgcctcctgccTCATACCTATTAAGGTCATtgtttttgagaaaggaggagc c" /listShort="cotJA, cotJB, cotJC, S246, yesJ, yesK" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(705462..705476) /Source="Nicolas_upshift_promotors" /id="U529" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=707 /SigmaFactorBS="ggcgtatatgatttgacaggcgtaaacggctgcatatccTTC ATtccggctCCTCCTTTCTCAAAAacaatgaccttaataggtatgaggcaggaggcat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(705467) /Source="Nicolas_upshifts" /id="U529" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=707 /SigmaFactorBS="ggcgtatatgatttgacaggcgtaaacggctgcatatccTTC ATtccggctCCTCCTTTCTCAAAAacaatgaccttaataggtatgaggcaggaggcat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(705484..705488) /Source="Nicolas_upshift_promotors" /id="U529" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=707 /SigmaFactorBS="ggcgtatatgatttgacaggcgtaaacggctgcatatccTTC ATtccggctCCTCCTTTCTCAAAAacaatgaccttaataggtatgaggcaggaggcat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 705484..705732 /gene="cotJA" /locus_tag="BSU_06890" /old_locus_tag="BSU06890" /function="16.5: Explore" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9364920" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9364920; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="component of the inner spore coat" /protein_id="NP_388570.1" /db_xref="EnsemblGenomes-Gn:BSU06890" /db_xref="EnsemblGenomes-Tr:CAB12508" /db_xref="InterPro:IPR020256" /db_xref="SubtiList:BG11799" /db_xref="UniProtKB/Swiss-Prot:Q45536" /translation="MKDMQPFTPVKSYTPFHSRFDPCPPIGKKYYRTPPNLYMTFQPE HMEQFSPMEALRKGTLWKDLYDFYENPYRGGDAHGKKG*" /label="cotJA CDS" gene 705484..705732 /gene="cotJA" /locus_tag="BSU_06890" /old_locus_tag="BSU06890" /label="cotJA gene" CDS 705716..705979 /gene="cotJB" /locus_tag="BSU_06900" /old_locus_tag="BSU06900" /function="16.13: Shape" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9364920" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9364920; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="component of the inner spore coat" /protein_id="NP_388571.2" /db_xref="EnsemblGenomes-Gn:BSU06900" /db_xref="EnsemblGenomes-Tr:CAB12509" /db_xref="InterPro:IPR016571" /db_xref="InterPro:IPR024207" /db_xref="SubtiList:BG11800" /db_xref="UniProtKB/Swiss-Prot:Q45537" /translation="MAKKVDAEYYRQLEQIQAADFVLVELSLYLNTHPHDEDALKQFN QYSGYSRHLKRQFESSYGPLLQFGNSPAGKDWDWGKGPWPWQV*" /label="cotJB CDS" gene 705716..705979 /gene="cotJB" /locus_tag="BSU_06900" /old_locus_tag="BSU06900" /label="cotJB gene" CDS 705994..706563 /gene="cotJC" /locus_tag="BSU_06910" /old_locus_tag="BSU06910" /EC_number="1.11.1.6" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:7768848, 9364920" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7768848, 9364920; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="enzyme component of the inner spore coat" /protein_id="NP_388572.1" /db_xref="EnsemblGenomes-Gn:BSU06910" /db_xref="EnsemblGenomes-Tr:CAB12510" /db_xref="InterPro:IPR007760" /db_xref="InterPro:IPR009078" /db_xref="InterPro:IPR012347" /db_xref="SubtiList:BG11801" /db_xref="UniProtKB/Swiss-Prot:Q45538" /translation="MWVYEKKLQYPVKVSTCNPTLAKYLIEQYGGADGELAAALRYLN QRYTIPDKVIGLLTDIGTEEFAHLEMIATMVYKLTKDATPEQLREAGLGDHYVNHDSA LFYHNAAGVPFTASYIQAKGDPIADLYEDIAAEEKARATYQWLIDISDDPDLNDSLRF LREREIVHSMRFREAVEILKEERDKKKIF*" /label="cotJC CDS" gene 705994..706563 /gene="cotJC" /locus_tag="BSU_06910" /old_locus_tag="BSU06910" /label="cotJC gene" S_feature 706564..706642 /Source="Nicolas_S_feature" /locus_tag="new_756987_757065" /HighExp="S4, S5, S3, S7, S6, B36, LoTm, BT, T5.0H, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S246" promotor_-35 706615..706620 /Source="Nicolas_upshift_promotors" /id="U530" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.518481518481518" /psig="0.999000999001" /xcortree=3085 /SigmaFactorBS="tcatacacccttttacatacagagaaaatggTCTGTTtttgc agtttggtcTGCATTATAATCAAGGTGTGtgtgcaagcttactttttgattgggaggc c" /listShort="yesJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 706635..706654 /Source="Nicolas_upshift_promotors" /id="U530" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.518481518481518" /psig="0.999000999001" /xcortree=3085 /SigmaFactorBS="tcatacacccttttacatacagagaaaatggTCTGTTtttgc agtttggtcTGCATTATAATCAAGGTGTGtgtgcaagcttactttttgattgggaggc c" /listShort="yesJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 706644 /Source="Nicolas_upshifts" /id="U530" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.518481518481518" /psig="0.999000999001" /xcortree=3085 /SigmaFactorBS="tcatacacccttttacatacagagaaaatggTCTGTTtttgc agtttggtcTGCATTATAATCAAGGTGTGtgtgcaagcttactttttgattgggaggc c" /listShort="yesJ" /GFF_Attribute="listLong" /label="upshifts" CDS 706688..707230 /gene="yesJ" /locus_tag="BSU_06920" /old_locus_tag="BSU06920" /EC_number="2.3.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_388573.1" /db_xref="EnsemblGenomes-Gn:BSU06920" /db_xref="EnsemblGenomes-Tr:CAB12511" /db_xref="GOA:O31513" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG11809" /db_xref="UniProtKB/Swiss-Prot:O31513" /translation="MTAFKIENETIADGFYACPAVYEDAESITGLLVRTAEWLRDRGS NQWSGLLKGQDIHDITGSIEKGHVFVFKKDEELAAVVMLLPAPSEWDRTLWGDDGHEE SIYLHRLAVSRRFAGQGLGARVLQWAETGIHFPEKTRIRLDCVADSDALHSFYRRMGY EFMGADASGYHLFEKEITAE*" /label="yesJ CDS" gene 706688..707230 /gene="yesJ" /locus_tag="BSU_06920" /old_locus_tag="BSU06920" /label="yesJ gene" downshifts 707197 /Source="Nicolas_upshifts" /id="D342" /incds=0 /nref=104 /ntot=251 /MaxReadThrough="3.04389" /MaxDrop="4.5316" /score="8.56782582" /energy="-5.8" /TU="U528" /idTUdmin="U530" /TUdmin=2 /isTUend="TRUE" /label="downshifts" CDS 707253..707555 /gene="yesK" /locus_tag="BSU_06930" /old_locus_tag="BSU06930" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane component" /protein_id="NP_388574.2" /db_xref="EnsemblGenomes-Gn:BSU06930" /db_xref="EnsemblGenomes-Tr:CAB12512" /db_xref="GOA:O31514" /db_xref="InterPro:IPR025434" /db_xref="SubtiList:BG12845" /db_xref="UniProtKB/Swiss-Prot:O31514" /translation="MSFSKREAGDVWSILFVTGIVTACLFAGVSVLMRMRFPDKSRPE WMLAGLIVLGVFAIWYSLVYVRGWEGAALGMLGFNVIFGAIAGYLIDKAIRRYRKR*" /label="yesK CDS" gene 707253..707555 /gene="yesK" /locus_tag="BSU_06930" /old_locus_tag="BSU06930" /label="yesK gene" promotor_-35 707598..707606 /Source="Nicolas_upshift_promotors" /id="U531" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.895104895104895" /psig="0.895104895104895" /xcortree=362 /SigmaFactorBS="gccgtctctcaacaggtcgaaattttcacagaccgGCAGGAA TTttctttcgaaAGGAGAAATACATATTACTttaaaatgaaagcgttttccaaagcag g" /listShort="yesL, yesM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 707617..707635 /Source="Nicolas_upshift_promotors" /id="U531" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.895104895104895" /psig="0.895104895104895" /xcortree=362 /SigmaFactorBS="gccgtctctcaacaggtcgaaattttcacagaccgGCAGGAA TTttctttcgaaAGGAGAAATACATATTACTttaaaatgaaagcgttttccaaagcag g" /listShort="yesL, yesM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 707623 /Source="Nicolas_upshifts" /id="U531" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.895104895104895" /psig="0.895104895104895" /xcortree=362 /SigmaFactorBS="gccgtctctcaacaggtcgaaattttcacagaccgGCAGGAA TTttctttcgaaAGGAGAAATACATATTACTttaaaatgaaagcgttttccaaagcag g" /listShort="yesL, yesM" /GFF_Attribute="listLong" /label="upshifts" CDS 707670..708299 /gene="yesL" /locus_tag="BSU_06940" /old_locus_tag="BSU06940" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 25441682; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease or sensor of a three componentsystem for pectin and rhamnogalacturonan transport anddegradation" /protein_id="NP_388575.1" /db_xref="EnsemblGenomes-Gn:BSU06940" /db_xref="EnsemblGenomes-Tr:CAB12513" /db_xref="GOA:O31515" /db_xref="InterPro:IPR006938" /db_xref="SubtiList:BG12846" /db_xref="UniProtKB/Swiss-Prot:O31515" /translation="MLMIHSVANGLNHFCTWVMRLAYLNVLWILFSLAGLVVFGLMPA TAAMFTVAREWAKGNTDAPVFSVFFRTFKKEWRASQILGLIVVTAALFLFADMRIAAQ MDQPVLVNVFVSISLIFAFVVLYVFPVFSHFDVKIREVLSISFFIAFSRPAVTLLMAA GAVGVLCLVLFHVTFLLFFSGSLLSLILTKLSFKAFRSMDQRQEKEKAA*" /label="yesL CDS" gene 707670..708299 /gene="yesL" /locus_tag="BSU_06940" /old_locus_tag="BSU06940" /label="yesL gene" CDS 708296..710029 /gene="yesM" /locus_tag="BSU_06950" /old_locus_tag="BSU06950" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295, 23436677, 25441682" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 23436677, 25441682; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YesN]" /protein_id="NP_388576.1" /db_xref="EnsemblGenomes-Gn:BSU06950" /db_xref="EnsemblGenomes-Tr:CAB12514" /db_xref="GOA:O31516" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR010559" /db_xref="InterPro:IPR033479" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12847" /db_xref="UniProtKB/Swiss-Prot:O31516" /translation="MKKRVAGWYRRMKIKDKLFVFLSLIMAVSFLFVYSGVQYAFHVY DEQIYRKSSEVLRMSSERIEDELKKIEDVSYEIITDEQIQRILSMQNRDDTYDQYQMK QELWDQLAGYASDEKYIDSIHVIDARGSEYSAGSSSSDLLQQEQEEVFKRAKAKSGRN LWMTLGGSDPVLISARQIRSYHQLSLNGLGMVLIQVNVKQMIRDVPKDWGDSVGDIMI ADQGGNLVYTAHASAHVPEAAKETLKHPGYDLIKKNGKRYFISYLQSSYQNWSYYNVI PFDQMFAKISFMKTVIGTCFLLFFCVVLLFGRKIANSITEPIEQLVTAMKSVQHSGIE AGVSLSLPEHTQDEAGMLNRHFTVMMKRINELMEENVEKQLIIKETELKALQAQINPH FLYNTLESINWLAKANQQKQISKMVESLGFLLRNSIHMKKDIVTIQEEADIVRHYMTI QRFRFEERLKFTLDIDDEVKHCLIPKLTLQPLAENAIQYALEPFTRPCAIRIQAKKAK GCVCITVEDNGPGMDGRILESTGGRGIGLWNIRERISLTFGEPYGLRIHSEHEKGTRI VITIPCRNEVV*" /label="yesM CDS" gene 708296..710029 /gene="yesM" /locus_tag="BSU_06950" /old_locus_tag="BSU06950" /label="yesM gene" CDS 710029..711135 /gene="yesN" /locus_tag="BSU_06960" /old_locus_tag="BSU06960" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:25441682" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25441682; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YesM]" /protein_id="NP_388577.1" /db_xref="EnsemblGenomes-Gn:BSU06960" /db_xref="EnsemblGenomes-Tr:CAB12515" /db_xref="GOA:O31517" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR018060" /db_xref="SubtiList:BG12848" /db_xref="UniProtKB/Swiss-Prot:O31517" /translation="MYKILLADDERIILDGMAGIIEWESLGASLIGKAQNGHEAYEKI VHKQPHIVITDVKMPGMDGLELIKKVSAVSPSVQFIVLSGFGEFEYAKEAMKYGVKHY LLKPCNEQQIISSLEEIIAELKRQDVHKKKTAHLKHELDHIRSFAADQYLEGLIAGVA QLSPPPSLAGKKIRLLILKGEQSIDAAAREALGSALTAVCSSGEWTVLAVEENAAEKV AEVFADRKMAISQAGELRHAGQLFRDTAEASGDLHGSAVISKMIRLIADELGNPNLSL KWAAKDMLFMNPDYLGKLFKQETGEKFSQYVTRVRLEHAMKQMKIRRDVSVSEIAEEI GFGDNPKYFSLVFKKYTGLTPSEFRRKQGGASAG*" /label="yesN CDS" gene 710029..711135 /gene="yesN" /locus_tag="BSU_06960" /old_locus_tag="BSU06960" /label="yesN gene" downshifts 711089 /Source="Nicolas_upshifts" /id="D343" /incds=0 /nref=4 /ntot=43 /MaxReadThrough="0.271749999999999" /MaxDrop="3.41261" /score="3.12085441" /energy="-10.3" /TU="NA" /idTUdmin="U531" /TUdmin=1408 /isTUend="FALSE" /label="downshifts" promotor_-35 711174..711177 /Source="Nicolas_upshift_promotors" /id="U532" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.882117882117882" /psig="0.992007992007992" /xcortree=356 /SigmaFactorBS="tctctgtttttttgactttcgccactgttttttgaGTGTttc gccctatccgaACGCTTTAAAATAAAATGTAagcacttacattaaaggggggattggt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 711192..711211 /Source="Nicolas_upshift_promotors" /id="U532" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.882117882117882" /psig="0.992007992007992" /xcortree=356 /SigmaFactorBS="tctctgtttttttgactttcgccactgttttttgaGTGTttc gccctatccgaACGCTTTAAAATAAAATGTAagcacttacattaaaggggggattggt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 711199 /Source="Nicolas_upshifts" /id="U532" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.882117882117882" /psig="0.992007992007992" /xcortree=356 /SigmaFactorBS="tctctgtttttttgactttcgccactgttttttgaGTGTttc gccctatccgaACGCTTTAAAATAAAATGTAagcacttacattaaaggggggattggt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 711239..712522 /gene="yesO" /locus_tag="BSU_06970" /old_locus_tag="BSU06970" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16781735, 17449691, 25658435" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16781735, 17449691, 25658435; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="pectin degradation byproducts (rhamnose oligosaccharides)-binding lipoprotein" /protein_id="NP_388578.2" /db_xref="EnsemblGenomes-Gn:BSU06970" /db_xref="EnsemblGenomes-Tr:CAB12516" /db_xref="PDB:4R6K" /db_xref="SubtiList:BG12849" /db_xref="UniProtKB/Swiss-Prot:O31518" /translation="MKKICYVLLSLVCVFLFSGCSAGEEASGKKEDVTLRIAWWGGQP RHDYTTKVIELYEKKNPHVHIEAEFANWDDYWKKLAPMSAAGQLPDVIQMDTAYLAQY GKKNQLEDLTPYTKDGTIDVSSIDENMLSGGKIDNKLYGFTLGVNVLSVIANEDLLKK AGVSINQENWTWEDYEKLAYDLQEKAGVYGSNGMHPPDIFFPYYLRTKGERFYKEDGT GLAYQDDQLFVDYFERQLRLVKAKTSPTPDESAQIKGMEDDFIVKGKSAITWNYSNQY LGFARLTDSPLSLYLPPEQMQEKALTLKPSMLFSIPKSSEHKKEAAKFINFFVNNEEA NQLIKGERGVPVSDKVADAIKPKLNEEETNIVEYVETASKNISKADPPEPVGSAEVIK LLKDTSDQILYQKVSPEKAAKTFRKKANEILERNN*" /label="yesO CDS" gene 711239..712522 /gene="yesO" /locus_tag="BSU_06970" /old_locus_tag="BSU06970" /label="yesO gene" CDS 712519..713448 /gene="rhgP" /locus_tag="BSU_06980" /old_locus_tag="BSU06980" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 17449691" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 17449691; Product type t: transporter" /codon_start=1 /transl_table=11 /product="rhamnogalacturonan permease" /protein_id="NP_388579.1" /db_xref="EnsemblGenomes-Gn:BSU06980" /db_xref="EnsemblGenomes-Tr:CAB12517" /db_xref="GOA:O31519" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12850" /db_xref="UniProtKB/Swiss-Prot:O31519" /translation="MTGNGADAMKKSRSIRKDNLAGYAFISPFIIGFLCFTVIPMGAS LFLSFTSYDLFTAPKWIGLDNFKEMFTGDEKYWQSLKVTFTYVLAGVPLRLGFALFIA VILNNAAKGTAIYRTLFYLPSIIGGSVAVAIMWRNIFGNDGVINALLFFVGIDQKILW YQNPTSALWTLILLSVWQFGSSMLIFLAGLKNIPSSYLEAASVDGANRVQRFFKITLP ILTPIIFFNLVMQTISAFMTFTPAYIISKGEGGPLDGTLLYSLYLFQRAFNYFQMGYA SAMAWVMLVIVGLITLILFKTSSYWVHYESKEE*" /label="rhgP CDS" gene 712519..713448 /gene="rhgP" /locus_tag="BSU_06980" /old_locus_tag="BSU06980" /label="rhgP gene" CDS 713452..714342 /gene="rhgQ" /locus_tag="BSU_06990" /old_locus_tag="BSU06990" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 17449691" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 17449691; Product type t: transporter" /codon_start=1 /transl_table=11 /product="rhamnogalacturonan permease" /protein_id="NP_388580.1" /db_xref="EnsemblGenomes-Gn:BSU06990" /db_xref="EnsemblGenomes-Tr:CAB12518" /db_xref="GOA:O31520" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12851" /db_xref="UniProtKB/Swiss-Prot:O31520" /translation="MEPVNQPVREAPVFERKKAGRVSPKRILFHVFTATLAVLLLYPV IWLFVSSFKESASIFTTSHSLIPDPFILSNYAEGWKGIAGQPFLTFIKNSAIIVGLST IGAVMSSAVIAYGFARIPFKGKKFWFACMMGTLMLPHEVLMIPQYIMFAKLDWLNSFK PIVVPQFFGHAFFIFLMIQFIRTIPEELDEAARIDGCGRFACFWRIILPLIAPALATS AIFSFYWKWEELIQPLLYLNKPELYPVSLALKLFLDTESASNWGAMFAMSAVSLLPVI LVFFLFQKYIVQGISTTGLK*" /label="rhgQ CDS" gene 713452..714342 /gene="rhgQ" /locus_tag="BSU_06990" /old_locus_tag="BSU06990" /label="rhgQ gene" CDS 714358..715392 /gene="rhgH" /locus_tag="BSU_07000" /old_locus_tag="BSU07000" /EC_number="3.2.1.172" /function="16.6: Maintain" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 16781735, 17449691; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="rhamnogalacturonan hydrolase" /protein_id="NP_388581.1" /db_xref="EnsemblGenomes-Gn:BSU07000" /db_xref="EnsemblGenomes-Tr:CAB12519" /db_xref="GOA:O31521" /db_xref="InterPro:IPR008928" /db_xref="InterPro:IPR010905" /db_xref="SubtiList:BG12852" /db_xref="UniProtKB/Swiss-Prot:O31521" /translation="MAQLIFDEEKVTSVIDRIVKRTFQMDFAWDWPGGVAFYGVAEAY EATENEEYINLLKTWVDEQLEDGLPPLSINGVSIGHTLLFLHKVTGDDVYLETAAEMA EYVLHKAPRFGEGILQHTVNAAEYVFPEQAWADTLMMAGLFMLRIGRVMEREDYFEDG LRQFHGHEDVLQDPVTNLYYHAWDNKAQNHLSGIYWGRANGWAALTMAKALPLIEVTH PSFMIIDGSLRDQLSALVRLQDESGLWHTILDDPDSYLEVSASAGIASALMSSGKLYT KYVQKSLAAILDAVEEDGRVSRVSAGTAVMKNAEGYKQVPYKRIQGWGQGLALTFLAD VLKTKKRLYQ*" /label="rhgH CDS" gene 714358..715392 /gene="rhgH" /locus_tag="BSU_07000" /old_locus_tag="BSU07000" /label="rhgH gene" CDS 715415..717700 /gene="rhgR" /locus_tag="BSU_07010" /old_locus_tag="BSU07010" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16781735, 17449691, 19651770" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16781735, 17449691, 19651770; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (AraC/XylS family)" /protein_id="NP_388582.1" /db_xref="EnsemblGenomes-Gn:BSU07010" /db_xref="EnsemblGenomes-Tr:CAB12520" /db_xref="GOA:O31522" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR018060" /db_xref="InterPro:IPR018062" /db_xref="SubtiList:BG12853" /db_xref="UniProtKB/Swiss-Prot:O31522" /translation="MKKQPQQKERVSRWKGTYFKRNFVFILLIACIPGLLTGGAIYFL SIDKVEKELQRSHETQVAREVSRMDEKLGVLELALTQMAYDSSLMNGLAERDLEKDFT FSYQLTKKLFLLRDQQPLIEQASIFLNSPRPLVLSPEYSALTEQEALRKYRSLLASDH SIYWKRSGNQAMLIQLIPGAAEKPFGAIMLAVDPKEMESILQSLSPYPDGSALLLDQN REVLFHEGEKDFEKTLLHEIKKQPAENGHFQMEWKGKVYSVSFGEMNRMHQQWTFVSA APLSAITAPMVFLSKVIIVMLVICIGLAVCMTWYASKKIYRPIQHLLGLFTGGEKKTW QASGQDEFKWIEKRWQDLSLESRKLQQQLLRQTPHMKKSFLQHLLQSDFYYDNEESLR FRMEEAGWNIGGNVFHVLDLQVTGLRCEKSIFREGDEQLAVFTLTNIAEELAAKRVFQ LSILDIGRLSVTVLVMKTNSSDLKAYITELARQFGDVTGLCLTSTLSSKTERVTEIPS LFQDVKCGKSRRKFANRDQVIDLQADFPRDEQFAPYYPFELEKQIVQTIRLERKQEAK ELIDGCMKELSEKAAIDRHVHSALIQLFSRIQEDILHSGLNPSELFQHRNPFLDISEL REPNEAAAWLMDVVVTPYLSKLEGRKNRQQKQLAERVIAMIHEQYMADISLESCADAL GMNSYTLSKAFKQVTGINFIDYVTQIRIEKAKELLVNTNKKIHDVSEEVGYRHNYFNR IFKKQVGMPPGVFRQMYQETP*" /label="rhgR CDS" gene 715415..717700 /gene="rhgR" /locus_tag="BSU_07010" /old_locus_tag="BSU07010" /label="rhgR gene" CDS 717714..718412 /gene="rhgT" /locus_tag="BSU_07020" /old_locus_tag="BSU07020" /EC_number="3.1.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16781735, 17449691, 17957779" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16781735, 17449691, 17957779; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="rhamnogalacturonan acetylesterase" /protein_id="NP_388583.1" /db_xref="EnsemblGenomes-Gn:BSU07020" /db_xref="EnsemblGenomes-Tr:CAB12521" /db_xref="GOA:O31523" /db_xref="InterPro:IPR013830" /db_xref="InterPro:IPR036514" /db_xref="SubtiList:BG12854" /db_xref="UniProtKB/Swiss-Prot:O31523" /translation="MMKKPIQVFLAGDSTVSDCPPHEAPMAGWGQVFGQLFSEGVLVR NHAKGGASTNSFVEEGRLQAIAEHITQGDYLLIQFGHNDQKPRGTKPYSTFQQFLTLF ADTAREKGAHPVFVTSVQRRRFDENGRIEHTLGEYPDAMKALAKELDVPVIDLLAKTK VLYEAYGPEESKRLFVWFQPNEHPNYPDGIEDNTHFSEKGAMEVAKLVAEGIEELGLP LKDHLVSREGKEHV*" /label="rhgT CDS" gene 717714..718412 /gene="rhgT" /locus_tag="BSU_07020" /old_locus_tag="BSU07020" /label="rhgT gene" CDS 718405..719067 /gene="yesU" /locus_tag="BSU_07030" /old_locus_tag="BSU07030" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16781735, 17449691; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_388584.1" /db_xref="EnsemblGenomes-Gn:BSU07030" /db_xref="EnsemblGenomes-Tr:CAB12522" /db_xref="InterPro:IPR013320" /db_xref="InterPro:IPR015305" /db_xref="PDB:1OQ1" /db_xref="SubtiList:BG12855" /db_xref="UniProtKB/Swiss-Prot:O31524" /translation="MYKEGACLYRNPLRSKSDVKDWRMEGGGQISFDDHSLHLSHVQD EAHFVFWCPETFPDGIIVTWDFSPIEQPGLCMLFFAAAGIRGEDLFDPSLRKRTGTYP EYHSGDINALHLSYFRRKYAEERAFRTCNLRKSRGFHLAAMGADPLPSPDDADSPYRM KLIKDKGYVHFSINGLPILEWMDDGSTYGPVLTKGKIGFRQMAPMKAVYRDFAVHQAV RR*" /label="yesU CDS" gene 718405..719067 /gene="yesU" /locus_tag="BSU_07030" /old_locus_tag="BSU07030" /label="yesU gene" CDS 719064..719690 /gene="yesV" /locus_tag="BSU_07040" /old_locus_tag="BSU07040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 17449691; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane component" /protein_id="NP_388585.1" /db_xref="EnsemblGenomes-Gn:BSU07040" /db_xref="EnsemblGenomes-Tr:CAB12523" /db_xref="InterPro:IPR006938" /db_xref="SubtiList:BG12856" /db_xref="UniProtKB/Swiss-Prot:O31525" /translation="MKTTVTDALYAGCEAVVKIAWLNGLWLLFTLLGGVLFGWAPSTA AMCAVIRKWLMGQKDVPIFSLFLDTYKKEFLKVNAIGLAFSALLLILSANYHYFSAST NWLSFAVTSCTLLAGLLYIIALMYVFPLYVHYQLPLRKYIPQALLFGAMRPLTTGCML IGCGFVLYLLYTLPGLIPFYGPCLFGLVLMFFALRGFQKTEAQHHQAG*" /label="yesV CDS" gene 719064..719690 /gene="yesV" /locus_tag="BSU_07040" /old_locus_tag="BSU07040" /label="yesV gene" CDS 719811..721673 /gene="rhgW" /locus_tag="BSU_07050" /old_locus_tag="BSU07050" /EC_number="4.2.2.23" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16781735, 17449691, 19193638" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16781735, 17449691, 19193638; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="rhamnogalacturonan endolyase" /protein_id="NP_388586.1" /db_xref="EnsemblGenomes-Gn:BSU07050" /db_xref="EnsemblGenomes-Tr:CAB12524" /db_xref="GOA:O31526" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR034641" /db_xref="PDB:2Z8R" /db_xref="PDB:2Z8S" /db_xref="PDB:2ZUX" /db_xref="SubtiList:BG12857" /db_xref="UniProtKB/Swiss-Prot:O31526" /translation="MRRSCLMIRRRKRMFTAVTLLVLLVMGTSVCPVKAEGAARQMEA LNRGLVAVKTDGGIFVSWRFLGTENASVLFNVYRDGQKLNAAPVKTTNYVDKNGSAGS TYTVRAVVNGTEQPASEKASVWAQPYHSVPLDKPAGGTTPKGESYTYSANDASVGDVD GDGQYELILKWDPSNSKDNSQDGYTGDVLIDAYKLDGTKLWRINLGKNIRAGAHYTQF MVYDLDGDGKAEVAMKTADGTKDGTGKVIGNANADYRNEQGRVLSGPEYLTVFQGSTG KELVTANFEPARGNVSDWGDSYGNRVDRFLAGIAYLDGQRPSLIMTRGYYAKTMLVAY NFRDGKLSKLWTLDSSKSGNEAFAGQGNHNLSIADVDGDGKDEIIFGSMAVDHDGKGM YSTGLGHGDALHTGDLDPGRPGLEVFQVHEDKNAKYGLSFRDAATGKILWGVYAGKDV GRGMAADIDPRYPGQEVWANGSLYSAKGVKIGSGVPSSTNFGIWWDGDLLREQLDSNR IDKWDYQNGVSKNMLTASGAAANNGTKATPTLQADLLGDWREEVVWRTEDSSALRIYT TTIPTEHRLYTLMHDPVYRLGIAWQNIAYNQPPHTSFFLGDGMAEQPKPNMYTP*" /label="rhgW CDS" gene 719811..721673 /gene="rhgW" /locus_tag="BSU_07050" /old_locus_tag="BSU07050" /label="rhgW gene" promotor_no_box 719851..719951 /Source="Nicolas_upshift_promotors" /id="U533" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.59040959040959" /psig="0.000999000999001" /xcortree=1487 /SigmaFactorBS="tgtttaccgctgttacgttgctggtcttgttggtgatgggaa cctctgtatgtcctgtgaaagctgaaggggcagcgcggcagatggaagcgctgaaccg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 719911 /Source="Nicolas_upshifts" /id="U533" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.59040959040959" /psig="0.000999000999001" /xcortree=1487 /SigmaFactorBS="tgtttaccgctgttacgttgctggtcttgttggtgatgggaa cctctgtatgtcctgtgaaagctgaaggggcagcgcggcagatggaagcgctgaaccg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(720449) /Source="Nicolas_upshifts" /id="U534" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1380 /SigmaFactorBS="cattgccacttctgctttTCCGTCACCAtcaaggtcatacAC CATAAACTGGGTGTAGTGcgcgcccgctctgatgtttttgccgagattgatccgccat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(720450..720469) /Source="Nicolas_upshift_promotors" /id="U534" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1380 /SigmaFactorBS="cattgccacttctgctttTCCGTCACCAtcaaggtcatacAC CATAAACTGGGTGTAGTGcgcgcccgctctgatgtttttgccgagattgatccgccat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(720482..720491) /Source="Nicolas_upshift_promotors" /id="U534" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1380 /SigmaFactorBS="cattgccacttctgctttTCCGTCACCAtcaaggtcatacAC CATAAACTGGGTGTAGTGcgcgcccgctctgatgtttttgccgagattgatccgccat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 721719..723557 /gene="rhgX" /locus_tag="BSU_07060" /old_locus_tag="BSU07060" /EC_number="4.2.2.24" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16781735, 17449691, 19193638" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16781735, 17449691, 19193638; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="rhamnogalacturonan exolyase" /protein_id="NP_388587.1" /db_xref="EnsemblGenomes-Gn:BSU07060" /db_xref="EnsemblGenomes-Tr:CAB12525" /db_xref="GOA:O31527" /db_xref="InterPro:IPR013517" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR034641" /db_xref="PDB:2ZUY" /db_xref="SubtiList:BG12858" /db_xref="UniProtKB/Swiss-Prot:O31527" /translation="MKPKKRQMEYLTRGLIAVQTEQGVFVSWRFLGTDHETTAFHLYR DGKRITRDPIAESTNFLDQNGTADSVYQVAAVNKGREEKLSKKARVWQENVLEVPLAK PEGGVTPDGKPYTYSANDASVGDIDGDGEYEMILKWDPSNSKDNAHDGYTGEVLIDAY KLDGTFLWRINLGRNIRAGAHYTQFMVYDLDGDGKAEIAMKTADGTTDGKGHIIGDEQ ADFRNEQGRILSGPEYLTVFKGETGEALTTVEYEPPRGKLEDWGDGYGNRMDRFLAGT AYLDGERPSLVMARGYYTRTVLVAYDFRNGRLKKRWVFDSNQPGHEAYAGQGNHSLSV ADVDGDGKDEIIYGAMAVDHDGTGLYSTGLGHGDAMHVGDLDPSRKGLEVFQVHEDAT KPYGLSLRDAGTGEILWGVHAGTDVGRGMAAHIDPSYKGSLVWGIDPPGNDGMSYGLF TSKGEKISDKAPSSANFAIWWDGDLVRELLDHDWDGTIGRPKIEKWDAENGCLKTIFQ PAGVLSNNGTKGNPVLQANLFGDWREEVIWRTEDSSALRIYTTTHLTRHCFYTLMHDP VYRLGIAWQNTAYNQPPHTSFYLGTGMKKPPKPALYIAGSKAEAPL*" /label="rhgX CDS" gene 721719..723557 /gene="rhgX" /locus_tag="BSU_07060" /old_locus_tag="BSU07060" /label="rhgX gene" CDS 723715..724368 /gene="yesY" /locus_tag="BSU_07070" /old_locus_tag="BSU07070" /EC_number="3.1.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16781735, 17449691" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16781735, 17449691; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="rhamnogalacturonan acetylesterase" /protein_id="NP_388588.1" /db_xref="EnsemblGenomes-Gn:BSU07070" /db_xref="EnsemblGenomes-Tr:CAB12526" /db_xref="GOA:O31528" /db_xref="InterPro:IPR013830" /db_xref="InterPro:IPR036514" /db_xref="SubtiList:BG12859" /db_xref="UniProtKB/Swiss-Prot:O31528" /translation="MANHIYLAGDSTVQTYGDSTNQGGWGQFLGSHLPEHIQVINRAI GGRSSKTFVEEGRLQAILDVIEPDDWLFVQMGHNDASKNKPERYTEPYTTYKQYLKQY IAGAREKGAHPLLITPVARFHYENGVFLNDFPDYCIAMKQTAAEENVQLIDLMEKSLA FFTEKGEEKVYTYFMISEGINDYTHFTKKGANEMAKLVAKGIKELGLPLTESIIKER* " /label="yesY CDS" gene 723715..724368 /gene="yesY" /locus_tag="BSU_07070" /old_locus_tag="BSU07070" /label="yesY gene" CDS 724376..726367 /gene="rhgZ" /locus_tag="BSU_07080" /old_locus_tag="BSU07080" /EC_number="3.2.1.67" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16781735, 17056685, 17449691, 17485082" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16781735, 17056685, 17449691, 17485082; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="beta-galacturonidase" /protein_id="NP_388589.1" /db_xref="EnsemblGenomes-Gn:BSU07080" /db_xref="EnsemblGenomes-Tr:CAB12527" /db_xref="GOA:O31529" /db_xref="InterPro:IPR003476" /db_xref="InterPro:IPR013529" /db_xref="InterPro:IPR013738" /db_xref="InterPro:IPR013739" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG12860" /db_xref="UniProtKB/Swiss-Prot:O31529" /translation="MRKLYHGACYYPELWDEETIQQDIDIMREVGVNVVRIGEFAWSV MEPEEGKIDVGFFKEIIARLYDSGIETIMCTPTPTPPIWFSHGRPERMHANEKREIMG HGSRQHACTNNPYFRKKAAIITTAIAKELGRLPGLIGWQLDNEFKCHVAECMCETCLR LWHDWLKNRYGVIERLNEAWGTDVWSETYQTFEQVPQPGPAPFLHHASLRTMYQLFSM EMIASFADEQAKIIRCYSDAPITHNGSVMFSVDNERMFQNLDFASYDTYASQENASAF LLNCDLWRNLKQGRPFWILETSPSYAASLESSAYPHADGYLQAEAVSSYALGSQGFCY WLWRQQRSGSEISHGSVLSAWGEPTIGYQNVLAVERARKEIEPIILSTEPVQAEAAMT YSDRAKAFIKTEPHRGLRHRSLVTHFYERILNTGIHRDLIPEGAPLDGYRLLFTPFVP YLSSEFIKKASAFAEAGGIWITGPLTGGRTCEHTIHTDCGLGELEKTSGIKTLFTFPM NENVNTGKAFGITAPLGLWSAVFDTESGNTLGTVEAGPGAGHAFLTERNYGEGKIVML GSLPSGKEGDAMLEALVRHYAEEAVISSRSDVTPGTIVAPRIGENGLVWIVVNMDGKG GSVTLPESGTDLLTHRLEKAGRLAVGPHEYRVIQFDNHS*" /label="rhgZ CDS" gene 724376..726367 /gene="rhgZ" /locus_tag="BSU_07080" /old_locus_tag="BSU07080" /label="rhgZ gene" CDS 726411..728984 /gene="yetA" /locus_tag="BSU_07090" /old_locus_tag="BSU07090" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_388590.2" /db_xref="EnsemblGenomes-Gn:BSU07090" /db_xref="EnsemblGenomes-Tr:CAB12528" /db_xref="SubtiList:BG12861" /db_xref="UniProtKB/Swiss-Prot:O31530" /translation="MKKIKWLSGQPKVTSGVTWGMPWKKGELKKGDRLALMNENAETR YVQSEPSAYWPDGSIKWTKHAAVFGGQENQSFTVHKREVPQPTESLSILETEHDIQVD TGALVCTIHKTGSDFIQSLQINGKPIAAGGRLVAIRETRKESAAKMVLLHERSVSFIK RAAIEQSGPVKAVVKIEGVHVLHKTYEEWLPFVIRLTFYAGLSEIGLVHTQLIDRSGK LEFVKGLGIEFDLFLEGEPYNRHFRFAGEKGMYKEPAQLFGTRKFNERYPLYEKQING EMLSPDEEHKEWFAHGTQNAVWDDVKIVQDSSDHYSLSKRTGKDYAWVGMLHGSRAKG LCYAGGKNGGVALGLRYFFEKYPSALEITGLAGSRPKMTIWLWPPDGEAMDLRHYTGN THVASAYEGFDEMRSDPTGIANTNEISLACFSHMPSDEVLNALADKWQAPPLIVCEPD VYYESKALGVWSIIDTSHPLKKELEEQLDAAFLFYKKEVEQRRWYGFWHYGDVMHTYD PIRHMWRYDLGGYAWQNNELVPTLWLWQAFFRSGREDIFRMAEAMTRHTSETDSFHLG EYAGLGSRHNVVHWGCGCKEARISMAGLHKFYYYLTGDDRTGDLLTEVKDADYALVKT DPMRAFYEKGKHPTHARTGPDWAAFCSNWLAEWERTENSEYLKKIETGINCLKRLPLR LLSGPTFEYDPATSMLHHMGDGIAGGYHMIIAFGAPQVWMELAELLDDWEWEDMLSEF GEFYTLSDEEKRKKSGGALHDGHFHWPMFAAGMTAYAARKKQDPHLAAKAWNLLLEDK LSHTPLPIKPERIETWTQLEELPWVTTNTVSQWCLNVIAALELIGDSLPAKKETSGKK G*" /label="yetA CDS" gene 726411..728984 /gene="yetA" /locus_tag="BSU_07090" /old_locus_tag="BSU07090" /label="yetA gene" promotor_-10 complement(727733..727751) /Source="Nicolas_upshift_promotors" /id="U535" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.916083916083916" /psig="0.916083916083916" /xcortree=961 /SigmaFactorBS="tgtcaatgatgctccataccccgagtgcttttgaTTCGTAat agacgtccggctcGCATACAATGAGCGGGGGCgcctgccatttgtcagccagcgcatt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(727746) /Source="Nicolas_upshifts" /id="U535" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.916083916083916" /psig="0.916083916083916" /xcortree=961 /SigmaFactorBS="tgtcaatgatgctccataccccgagtgcttttgaTTCGTAat agacgtccggctcGCATACAATGAGCGGGGGCgcctgccatttgtcagccagcgcatt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(727767..727772) /Source="Nicolas_upshift_promotors" /id="U535" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.916083916083916" /psig="0.916083916083916" /xcortree=961 /SigmaFactorBS="tgtcaatgatgctccataccccgagtgcttttgaTTCGTAat agacgtccggctcGCATACAATGAGCGGGGGCgcctgccatttgtcagccagcgcatt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 729106..730614 /gene="lplA" /locus_tag="BSU_07100" /old_locus_tag="BSU07100" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7921237" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7921237; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="lipoprotein transporter binding protein for alpha-galacturonides" /protein_id="NP_388591.1" /db_xref="EnsemblGenomes-Gn:BSU07100" /db_xref="EnsemblGenomes-Tr:CAB12529" /db_xref="GOA:P37966" /db_xref="InterPro:IPR006059" /db_xref="SubtiList:BG10434" /db_xref="UniProtKB/Swiss-Prot:P37966" /translation="MKIRMRKKWMALPLAAMMIAGCSHSETSNSASGSKDTIKIMAPL LSPESPSDKSPSLKALEKYTGKEIKVTWVPDSSYNDKFNIVMASGEMPHAIVIKDKSA GFIKSVKAGAFWELSPYLKDYKNLSQADEKILKNSSVNGEVYGIYRTRDLIRACMIIR TDWLKNVGLDMPETLDDFYEVLKAFKEKDPDGNGKDDTYGMVVPKWMGLGNGSPWDVL QIWFGAPNRYGVENGKLIPDFTTKEYMDALTFFKKLYDEGLINKDFAVMDSAKWNDPV VKGKAGVIVDTGSRASQIQSAMEEADESNKDIIDIVGSLEGPNGKRTFPTSGYSGMIT IPKSSVKTEKELKEVLSFLDKMNDKEAQILTNNGVKGRNYELKDGVFTSLEKNNKSLL YEHEGLAQFSMSIPKSEYYIEDQKTKLFQHRKDIITEGEKIAVFNPAESLVSDVYTQK GAQLDNIILDARTQFIIGEIDEKGFDDAVELWKKSGGNELMKDLNKLYQSSK*" /label="lplA CDS" gene 729106..730614 /gene="lplA" /locus_tag="BSU_07100" /old_locus_tag="BSU07100" /label="lplA gene" CDS 730669..731625 /gene="lplB" /locus_tag="BSU_07110" /old_locus_tag="BSU07110" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 10869078, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (permease) for alpha-galacturonides" /protein_id="NP_388592.1" /db_xref="EnsemblGenomes-Gn:BSU07110" /db_xref="EnsemblGenomes-Tr:CAB12530" /db_xref="GOA:P39128" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG10435" /db_xref="UniProtKB/Swiss-Prot:P39128" /translation="METVPKKRDAPVLTAGKGISWMAALKRDKWLYLLLIPGLLYFLI FKYLPMWGVLIAFKDYSPYLGFWKSEWVGFDYFKDFFMNPDFFRLLRNTLMLASLDLL FAFPAPLILALLLNEVRKAVYKRCIQTFIYVPHFVSWTIVVSITFVFFTVDTGVINKL IMSLTGEQISFLSDADWFRPMIVMQSIWKETGWGTILFLAALATVDQEQYEAAIMDGA GRFRRMWHITLPAIRSTIIVLLILRIGSFLNLGFEQVYLMTNSLNRSVADIFDTYVYM MGITQGAYSYSTAVGLFKSVVGIILIFGANYIAKKFDQEGLF*" /label="lplB CDS" gene 730669..731625 /gene="lplB" /locus_tag="BSU_07110" /old_locus_tag="BSU07110" /label="lplB gene" downshifts complement(730943) /Source="Nicolas_upshifts" /id="D344" /incds=1 /nref=1 /ntot=8 /MaxReadThrough="1.59638" /MaxDrop="4.19822" /score="13.9744253" /energy="-20.3" /TU="NA" /idTUdmin="U538" /TUdmin=2068 /isTUend="FALSE" /label="downshifts" promotor_no_box complement(730969..731069) /Source="Nicolas_upshift_promotors" /id="U536" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.544455544455544" /psig="0.002997002997003" /xcortree=1476 /SigmaFactorBS="ggtacgtaaataaaggtttggatacatcttttatacacggcc tttcttacctcattcaaaagcagagccaaaatgagaggcgcgggaaaggcaaacaaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(731009) /Source="Nicolas_upshifts" /id="U536" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.544455544455544" /psig="0.002997002997003" /xcortree=1476 /SigmaFactorBS="ggtacgtaaataaaggtttggatacatcttttatacacggcc tttcttacctcattcaaaagcagagccaaaatgagaggcgcgggaaaggcaaacaaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 731639..732526 /gene="lplC" /locus_tag="BSU_07120" /old_locus_tag="BSU07120" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 10869078, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (permease) for alpha-galacturonides" /protein_id="NP_388593.1" /db_xref="EnsemblGenomes-Gn:BSU07120" /db_xref="EnsemblGenomes-Tr:CAB12531" /db_xref="GOA:P39129" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG10857" /db_xref="UniProtKB/Swiss-Prot:P39129" /translation="MAEIHTMHNTKAGRVFDVCNILFLGGVGAITILPFLYIIAGSFA TEAELAQRSFFIFPKTFTLDAYKYVFSTPTFLRSMGVSIFITVVGTAVQLFFTFTMAY PLAKRHVKGRNLLLNLVIFSMLFSGGMIPTYLVVKSLGLLDTYWALILPMAINPFNLI IIKNFFQQLPRELEESAKIDGCSEIGVFWRIALPLSKPVIATFALFYAVGIWNDFFHA LLYINDSAKWPLQMVLRQVTILSDLTATNGDTMQNAVPPEQGIKLAVIVIATLPILAV YPFLQKHFAKGMLIGSVKG*" /label="lplC CDS" gene 731639..732526 /gene="lplC" /locus_tag="BSU_07120" /old_locus_tag="BSU07120" /label="lplC gene" promotor_-35 732273..732278 /Source="Nicolas_upshift_promotors" /id="U537" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1069 /SigmaFactorBS="ttgcgacctttgcgctgttttatgcggtcgggatttGGAATG atttcttccacgctcTCTTATATATCAATGACAGtgcaaaatggccgctgcaaatggt g" /listShort="lplD, S248, yetF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 732294..732312 /Source="Nicolas_upshift_promotors" /id="U537" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1069 /SigmaFactorBS="ttgcgacctttgcgctgttttatgcggtcgggatttGGAATG atttcttccacgctcTCTTATATATCAATGACAGtgcaaaatggccgctgcaaatggt g" /listShort="lplD, S248, yetF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 732297 /Source="Nicolas_upshifts" /id="U537" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1069 /SigmaFactorBS="ttgcgacctttgcgctgttttatgcggtcgggatttGGAATG atttcttccacgctcTCTTATATATCAATGACAGtgcaaaatggccgctgcaaatggt g" /listShort="lplD, S248, yetF" /GFF_Attribute="listLong" /label="upshifts" CDS 732535..733875 /gene="lplD" /locus_tag="BSU_07130" /old_locus_tag="BSU07130" /EC_number="3.2.1.67" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:23416295" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23416295; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alpha-galacturonidase" /protein_id="NP_388594.1" /db_xref="EnsemblGenomes-Gn:BSU07130" /db_xref="EnsemblGenomes-Tr:CAB12532" /db_xref="GOA:P39130" /db_xref="InterPro:IPR001088" /db_xref="InterPro:IPR015955" /db_xref="InterPro:IPR019802" /db_xref="InterPro:IPR022616" /db_xref="InterPro:IPR036291" /db_xref="PDB:3FEF" /db_xref="SubtiList:BG10858" /db_xref="UniProtKB/Swiss-Prot:P39130" /translation="MFHISTLDQIKIAYIGGGSQGWARSLMSDLSIDERMSGTVALYD LDFEAAQKNEVIGNHSGNGRWRYEAVSTLKKALSAADIVIISILPGSLDDMEVDVHLP ERCGIYQSVGDTVGPGGIIRGLRAVPIFAEIARAIRDYAPESWVINYTNPMSVCTRVL YKVFPGIKAIGCCHEVFGTQKLLAEMVTERLGIEVPRREDIRVNVLGINHFTWITKAS YRHIDLLPIFREFSAHYGESGYELEGECWRDSVFCSAHRVAFDLFETYGAIPAAGDRH LAEFLPGPYLKQPEVWKFHLTPISFRKQDRAEKRQETERLIVQQRGVAEKASGEEGVN IIAALLGLGELVTNVNMPNQGQVLNLPIQAIVETNAFITRNRVQPILSGALPKGVEML AARHISNQEAVADAGLTKDTGLAFQAFLNDPLVQIDRSDAEQLFNDMLQCIMQS*" /label="lplD CDS" gene 732535..733875 /gene="lplD" /locus_tag="BSU_07130" /old_locus_tag="BSU07130" /label="lplD gene" S_feature complement(732969..734660) /Source="Nicolas_S_feature" /locus_tag="new_783392_785083_c" /HighExp="H2O2, dia15, Paraq, Lbexp, LBGexp, Salt, LPhT, GM 25, G150, dia0" /AntisenseName="yetF" /AntisenseCor="-0.25986434675098202" /AntisenseRegPval="-4.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigA" /TUlongPSig="0.993" /label="S247" S_feature 733876..733957 /Source="Nicolas_S_feature" /locus_tag="new_784299_784380" /HighExp="S5, S4, S6, S3, S7, S8, BT, LoTm, B36, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.991" /TUlongSig="NA" /TUlongPSig="NA" /label="S248" CDS 733958..734653 /gene="yetF" /locus_tag="BSU_07140" /old_locus_tag="BSU07140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="conserved membrane protein" /protein_id="NP_388595.1" /db_xref="EnsemblGenomes-Gn:BSU07140" /db_xref="EnsemblGenomes-Tr:CAB12533" /db_xref="GOA:O31533" /db_xref="InterPro:IPR007353" /db_xref="InterPro:IPR023090" /db_xref="PDB:3C6F" /db_xref="SubtiList:BG12862" /db_xref="UniProtKB/Swiss-Prot:O31533" /translation="MGNYLSVAVELVCGLGILFIILKLLGKTQFSQITPFDFISALIL GELVGNAVYDHEIKIKEIIFASLLWGVLIYIIEFITQKMKSSRKFLEGEPNIVIRKGE LQYKVMKKNKIDINQLQSLLRQAGSFSIQEVEYAILETNGMVSVLPKSDFDKPTNKDL QIPSKSVSLPITLIIDGEIVRDNLKEAGVDEQWLKQELKKKNIDKTEDVLFAEWHKNK PLYTVTYEQSRST*" /label="yetF CDS" gene 733958..734653 /gene="yetF" /locus_tag="BSU_07140" /old_locus_tag="BSU07140" /label="yetF gene" downshifts 734651 /Source="Nicolas_upshifts" /id="D345" /incds=0 /nref=2 /ntot=24 /MaxReadThrough="1.32891" /MaxDrop="3.45213" /score="-0.176154378" /energy="-7.1" /TU="NA" /idTUdmin="U537" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(734690..735016) /gene="hmoA" /locus_tag="BSU_07150" /old_locus_tag="BSU07150" /EC_number="1.14.14.18" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:20180905, 21764939, 21873409" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20180905, 21764939, 21873409; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="heme-degrading monooxygenase" /protein_id="NP_388596.2" /db_xref="EnsemblGenomes-Gn:BSU07150" /db_xref="EnsemblGenomes-Tr:CAB12534" /db_xref="GOA:O31534" /db_xref="InterPro:IPR007138" /db_xref="InterPro:IPR011008" /db_xref="SubtiList:BG12863" /db_xref="UniProtKB/Swiss-Prot:O31534" /translation="MFVQLRKMTVKEGFADKVIERFSAEGIIEKQEGLIDVTVLEKNV RRGDEEVVVMIRWESEDHWKQWEKSDAHIAGHKANKGKPKPDYLISTEVSMYHVRAVK QGTYNQ*" /label="hmoA CDS" gene complement(734690..735016) /gene="hmoA" /locus_tag="BSU_07150" /old_locus_tag="BSU07150" /label="hmoA gene" downshifts complement(734705) /Source="Nicolas_upshifts" /id="D346" /incds=0 /nref=194 /ntot=248 /MaxReadThrough="4.01189" /MaxDrop="6.29183" /score="9.23596913" /energy="-9.1" /TU="U538" /idTUdmin="U539" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 735003 /Source="Nicolas_upshifts" /id="D347" /incds=1 /nref=1 /ntot=45 /MaxReadThrough="1.96802" /MaxDrop="3.46057" /score="-7.34187128" /energy="-5" /TU="NA" /idTUdmin="U537" /TUdmin=352 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(735039..735058) /Source="Nicolas_upshift_promotors" /id="U538" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.604395604395604" /psig="0.999000999001" /xcortree=2117 /SigmaFactorBS="tgttgcgcacggcggttcgattccgccctgcgctttcTTTGA CATtgagaatgaatttcATTTACAATTATTCATATGTgagaatgattggagtgagaca a" /listShort="yetG, S247" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(735057) /Source="Nicolas_upshifts" /id="U538" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.604395604395604" /psig="0.999000999001" /xcortree=2117 /SigmaFactorBS="tgttgcgcacggcggttcgattccgccctgcgctttcTTTGA CATtgagaatgaatttcATTTACAATTATTCATATGTgagaatgattggagtgagaca a" /listShort="yetG, S247" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(735073..735080) /Source="Nicolas_upshift_promotors" /id="U538" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.604395604395604" /psig="0.999000999001" /xcortree=2117 /SigmaFactorBS="tgttgcgcacggcggttcgattccgccctgcgctttcTTTGA CATtgagaatgaatttcATTTACAATTATTCATATGTgagaatgattggagtgagaca a" /listShort="yetG, S247" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(735120..735482) /gene="yetH" /locus_tag="BSU_07160" /old_locus_tag="BSU07160" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative lyase/dioxygenase" /protein_id="NP_388597.1" /db_xref="EnsemblGenomes-Gn:BSU07160" /db_xref="EnsemblGenomes-Tr:CAB12535" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG12864" /db_xref="UniProtKB/Swiss-Prot:O31535" /translation="MIKQIGTVAVYVEDQQKAKQFWTEKVGFDIAADHPMGPEASWLE VAPKGAETRLVIYPKAMMKGSEQMKASIVFECEDIFGTYEKMKTNGVEFLGEPNQMEW GTFVQFKDEDGNVFLLKE*" /label="yetH CDS" gene complement(735120..735482) /gene="yetH" /locus_tag="BSU_07160" /old_locus_tag="BSU07160" /label="yetH gene" promotor_-10 complement(735505..735524) /Source="Nicolas_upshift_promotors" /id="U539" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.431568431568432" /psig="0.993006993006993" /xcortree=2376 /SigmaFactorBS="ttttaataatcagccggtttcccggctgatttttttATGTTA CttcggccgtaaaCAGGTTATAGTATTATTATCttttcaacttggaggtttccctatg a" /listShort="yetH, yetG" /listLong="S247" /label="promotor_-10" upshifts complement(735519) /Source="Nicolas_upshifts" /id="U539" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.431568431568432" /psig="0.993006993006993" /xcortree=2376 /SigmaFactorBS="ttttaataatcagccggtttcccggctgatttttttATGTTA CttcggccgtaaaCAGGTTATAGTATTATTATCttttcaacttggaggtttccctatg a" /listShort="yetH, yetG" /listLong="S247" /label="upshifts" promotor_-35 complement(735537..735543) /Source="Nicolas_upshift_promotors" /id="U539" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.431568431568432" /psig="0.993006993006993" /xcortree=2376 /SigmaFactorBS="ttttaataatcagccggtttcccggctgatttttttATGTTA CttcggccgtaaaCAGGTTATAGTATTATTATCttttcaacttggaggtttccctatg a" /listShort="yetH, yetG" /listLong="S247" /label="promotor_-35" S_feature complement(735553..736113) /Source="Nicolas_S_feature" /locus_tag="new_785976_786536_c" /HighExp="S8, S6, S7, S5, BT, B36, G/S, B60, Pyr, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99999400000000005" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S249" downshifts complement(735585) /Source="Nicolas_upshifts" /id="D348" /incds=0 /nref=38 /ntot=47 /MaxReadThrough="0.395850000000001" /MaxDrop="8.2984" /score="45.4672528" /energy="-13.7" /TU="NA" /idTUdmin="U540" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(736096..736115) /Source="Nicolas_upshift_promotors" /id="U540" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1291 /SigmaFactorBS="ctctctgagagcattccagcttcatatccttaggcGAATGCA CCAataagagtccgccCGCATAAACTGCAATGTACAgtttacaatgagaaaggacgtt a" /listShort="S249" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(736113) /Source="Nicolas_upshifts" /id="U540" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1291 /SigmaFactorBS="ctctctgagagcattccagcttcatatccttaggcGAATGCA CCAataagagtccgccCGCATAAACTGCAATGTACAgtttacaatgagaaaggacgtt a" /listShort="S249" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(736129..736138) /Source="Nicolas_upshift_promotors" /id="U540" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1291 /SigmaFactorBS="ctctctgagagcattccagcttcatatccttaggcGAATGCA CCAataagagtccgccCGCATAAACTGCAATGTACAgtttacaatgagaaaggacgtt a" /listShort="S249" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 736201..736208 /Source="Nicolas_upshift_promotors" /id="U541" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.915084915084915" /psig="0.999000999001" /xcortree=2437 /SigmaFactorBS="ggaatgctctcagagagcagaatcatttgatttttctctagt ctTATTCACAattccgatttatCATTTTATAATGAAAGTGCTtctattacgaaaaagg a" /listShort="yetI, yetI" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 736217 /Source="Nicolas_upshifts" /id="U541" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.915084915084915" /psig="0.999000999001" /xcortree=2437 /SigmaFactorBS="ggaatgctctcagagagcagaatcatttgatttttctctagt ctTATTCACAattccgatttatCATTTTATAATGAAAGTGCTtctattacgaaaaagg a" /listShort="yetI, yetI" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 736221..736240 /Source="Nicolas_upshift_promotors" /id="U541" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.915084915084915" /psig="0.999000999001" /xcortree=2437 /SigmaFactorBS="ggaatgctctcagagagcagaatcatttgatttttctctagt ctTATTCACAattccgatttatCATTTTATAATGAAAGTGCTtctattacgaaaaagg a" /listShort="yetI, yetI" /GFF_Attribute="listLong" /label="promotor_-10" CDS 736266..736847 /gene="yetI" /locus_tag="BSU_07170" /old_locus_tag="BSU07170" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 11157946; Product type r: regulator" /pseudo /codon_start=1 /transl_table=11 /product="putative paralog of RsbR; N-terminal part of YetI" /db_xref="SubtiList:BG12865" /translation="MNIDQLLYQYIIDNTADITEKWFSLRCQLKGELYSASHLSEETK TLLTEQHTFTNITIASAFLEDQTDFQENMTKWAQNVAKNRVEQDVQVHEVVEAISNSR ISFWDAVATFIKENQEIVTNEDADRWNRIVNQSFDKLIIEFSEQYQKFMLMRLTSQQE LISELGCPVISIADGIGILPLIGSIDTKRHRSF*" /label="yetI CDS" gene 736266..736847 /gene="yetI" /locus_tag="BSU_07170" /old_locus_tag="BSU07170" /pseudo /label="yetI gene" CDS 736841..737137 /gene="yetI" /locus_tag="BSU_07180" /old_locus_tag="BSU07180" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 11157946; Product type r: regulator" /pseudo /codon_start=1 /transl_table=11 /product="putative paralog of RsbR; C-terminal part of YetI" /db_xref="GOA:O31537" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR036513" /db_xref="PSEUDO:CAB12537.2" /db_xref="SubtiList:BG12873" /db_xref="UniProtKB/Swiss-Prot:O31537" /translation="MLETVPVRCVERKITSLVVDLSGVPIVDTMVAQQLYNLSKTLFL LGVKAVFSGIRPDVAQTSIQLGLDFSEYETYGTLKQALENMGVRCIVEELEENK*" /label="yetI CDS" gene 736841..737137 /gene="yetI" /locus_tag="BSU_07180" /old_locus_tag="BSU07180" /pseudo /label="yetI gene" downshifts 737129 /Source="Nicolas_upshifts" /id="D349" /incds=0 /nref=114 /ntot=215 /MaxReadThrough="1.06939" /MaxDrop="4.8053" /score="16.356572" /energy="-21.2" /TU="NA" /idTUdmin="U541" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" promotor_-35 737208..737215 /Source="Nicolas_upshift_promotors" /id="U542" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.603396603396603" /psig=1 /xcortree=1743 /SigmaFactorBS="atatgcctttttgatttgaacagaaatcaccATTGATTTatc gaaaaaaacaTAATATTATAATTCTTATAAgaatactgtgaattaaaacctattcaac a" /listShort="yezD, yetJ, yetK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 737229..737248 /Source="Nicolas_upshift_promotors" /id="U542" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.603396603396603" /psig=1 /xcortree=1743 /SigmaFactorBS="atatgcctttttgatttgaacagaaatcaccATTGATTTatc gaaaaaaacaTAATATTATAATTCTTATAAgaatactgtgaattaaaacctattcaac a" /listShort="yezD, yetJ, yetK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 737237 /Source="Nicolas_upshifts" /id="U542" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.603396603396603" /psig=1 /xcortree=1743 /SigmaFactorBS="atatgcctttttgatttgaacagaaatcaccATTGATTTatc gaaaaaaacaTAATATTATAATTCTTATAAgaatactgtgaattaaaacctattcaac a" /listShort="yezD, yetJ, yetK" /GFF_Attribute="listLong" /label="upshifts" CDS 737292..737459 /gene="yezD" /locus_tag="BSU_07190" /old_locus_tag="BSU07190" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388600.1" /db_xref="EnsemblGenomes-Gn:BSU07190" /db_xref="EnsemblGenomes-Tr:CAB12538" /db_xref="InterPro:IPR018743" /db_xref="SubtiList:BG12875" /db_xref="UniProtKB/Swiss-Prot:O31538" /translation="MVSKSTIDPEVIEKIISSLETLDFGTVQITVHDSQITQIEKIEK HRFSLKRKESK*" /label="yezD CDS" gene 737292..737459 /gene="yezD" /locus_tag="BSU_07190" /old_locus_tag="BSU07190" /label="yezD gene" promotor_-35 737501..737508 /Source="Nicolas_upshift_promotors" /id="U543" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2401 /SigmaFactorBS="taaagggcgtttgttttcattaaattctccttaaaaCATATA CAtatttcatccaatttTTATATAATAGACCTTTAAGatcattttttaggaggatttt t" /listShort="yetJ, yetK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 737524..737543 /Source="Nicolas_upshift_promotors" /id="U543" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2401 /SigmaFactorBS="taaagggcgtttgttttcattaaattctccttaaaaCATATA CAtatttcatccaatttTTATATAATAGACCTTTAAGatcattttttaggaggatttt t" /listShort="yetJ, yetK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 737525 /Source="Nicolas_upshifts" /id="U543" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2401 /SigmaFactorBS="taaagggcgtttgttttcattaaattctccttaaaaCATATA CAtatttcatccaatttTTATATAATAGACCTTTAAGatcattttttaggaggatttt t" /listShort="yetJ, yetK" /GFF_Attribute="listLong" /label="upshifts" CDS 737569..738213 /gene="calJ" /locus_tag="BSU_07200" /old_locus_tag="BSU07200" /function="7.4: Cations and iron carrying compounds" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 16086852, 24904158" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 16086852, 24904158; Product type t: transporter" /codon_start=1 /transl_table=11 /product="pH-sensitive calcium-leak permease (di-aspartyl pH sensor)" /protein_id="NP_388601.1" /db_xref="EnsemblGenomes-Gn:BSU07200" /db_xref="EnsemblGenomes-Tr:CAB12539" /db_xref="GOA:O31539" /db_xref="InterPro:IPR006214" /db_xref="PDB:4PGR" /db_xref="PDB:4PGS" /db_xref="PDB:4PGU" /db_xref="PDB:4PGV" /db_xref="PDB:4PGW" /db_xref="PDB:4TKQ" /db_xref="SubtiList:BG12866" /db_xref="UniProtKB/Swiss-Prot:O31539" /translation="MQATVHESKQSIMQRILTVFVFTLLIATVGLFIGQFVPVALMLP LSILEVAMIILAFWMRRRKAVGYAFVYTFAFVSGITLFPIVSHYASIAGAYVVLEAFG STFVIFAVLGTIGAKMKKDLSFLWSFLLVAVLALAVVGIFNIFSPLNSAAMMAYSVIG TIVFSLYILYDLNQIKHRHITEDLIPVMALSLYLDFINLFINLLRFFGILSSDD*" /label="calJ CDS" gene 737569..738213 /gene="calJ" /locus_tag="BSU_07200" /old_locus_tag="BSU07200" /label="calJ gene" downshifts 738149 /Source="Nicolas_upshifts" /id="D350" /incds=1 /nref=1 /ntot=11 /MaxReadThrough="6.69003" /MaxDrop="2.5446" /score="-1.46791202" /energy="-10.7" /TU="U542,U543" /idTUdmin="U541" /TUdmin=1012 /isTUend="FALSE" /label="downshifts" downshifts 738193 /Source="Nicolas_upshifts" /id="D351" /incds=0 /nref=7 /ntot=127 /MaxReadThrough="5.33515" /MaxDrop="3.71552" /score="-1.46791202" /energy="-10.7" /TU="U542,U543" /idTUdmin="U542" /TUdmin="-990" /isTUend="FALSE" /label="downshifts" CDS 738213..739205 /gene="yetK" /locus_tag="BSU_07210" /old_locus_tag="BSU07210" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388602.1" /db_xref="EnsemblGenomes-Gn:BSU07210" /db_xref="EnsemblGenomes-Tr:CAB12540" /db_xref="GOA:O31540" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG12867" /db_xref="UniProtKB/Swiss-Prot:O31540" /translation="MKKRLSLDRRFLPYIKKAGGVLVKKQMGAYVSLAAAMAIVGSSV VVGKLMVERIPVFLSSGLRFLIASVVLLMLLFCIEKGFPALTKKDVFVLLVQSFTGVF LFSICLLYGVQYTTGTESGILTSTTPMLIGILSFFLLREKIEKKTLIGILLAVCGVMA INLFGAGSQDGTPHALFGNMLIIAAVIGEALFTLMAKLLSPHISALAISTFVSLFGFL FFLPFALFEASSFDYSVPTVLDWSYVLYYALFVTVLAFYLWYSGVTKVPAGVSGIFTS VLPVSAVILSGVILKEPFEFVHFIGIACVIGGIFVTVIKKKQPDAYPAAEEKTL*" /label="yetK CDS" gene 738213..739205 /gene="yetK" /locus_tag="BSU_07210" /old_locus_tag="BSU07210" /label="yetK gene" downshifts 739139 /Source="Nicolas_upshifts" /id="D352" /incds=1 /nref=1 /ntot=18 /MaxReadThrough="4.14475" /MaxDrop="2.73453" /score="21.8095329" /energy="-10.7" /TU="U542,U543" /idTUdmin="U542" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" downshifts 739183 /Source="Nicolas_upshifts" /id="D353" /incds=0 /nref=94 /ntot=214 /MaxReadThrough="0.120229999999999" /MaxDrop="4.45909" /score="21.8095329" /energy="-10.7" /TU="NA" /idTUdmin="U542" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(739229..739732) /gene="flvL" /locus_tag="BSU_07220" /old_locus_tag="BSU07220" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:19329649, 25209494" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19329649, 25209494; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (FlvL-flavonoids)" /protein_id="NP_388603.1" /db_xref="EnsemblGenomes-Gn:BSU07220" /db_xref="EnsemblGenomes-Tr:CAB12541" /db_xref="GOA:O31541" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12868" /db_xref="UniProtKB/Swiss-Prot:O31541" /translation="MELKHLPKYKHITEHAETYANIDAGSLELFLSLFDISKKMNHVM EHYFAGRGLSEGKFKILMLLFDAKDHRLSPTELAKRSNVTKATITGLLDGLARDGFVS RRHHTEDKRKISIELTTEGKARLEQFLPGHFSKISAVMENYSDEEKDMFVKMLGDLFE RLSVFKD*" /label="flvL CDS" gene complement(739229..739732) /gene="flvL" /locus_tag="BSU_07220" /old_locus_tag="BSU07220" /label="flvL gene" promotor_-10 complement(739757..739776) /Source="Nicolas_upshift_promotors" /id="U544" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.739260739260739" /psig="0.952047952047952" /xcortree=3006 /SigmaFactorBS="aagaaaagctgtcaatcatctccaagccAAGTTGCGttatgg ttttcccTCCTTTATAATCGTGTCACAacgaatgtacgggagctaattgcgatggaat t" /listShort="yetL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(739765) /Source="Nicolas_upshifts" /id="U544" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.739260739260739" /psig="0.952047952047952" /xcortree=3006 /SigmaFactorBS="aagaaaagctgtcaatcatctccaagccAAGTTGCGttatgg ttttcccTCCTTTATAATCGTGTCACAacgaatgtacgggagctaattgcgatggaat t" /listShort="yetL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(739790..739797) /Source="Nicolas_upshift_promotors" /id="U544" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.739260739260739" /psig="0.952047952047952" /xcortree=3006 /SigmaFactorBS="aagaaaagctgtcaatcatctccaagccAAGTTGCGttatgg ttttcccTCCTTTATAATCGTGTCACAacgaatgtacgggagctaattgcgatggaat t" /listShort="yetL" /GFF_Attribute="listLong" /label="promotor_-35" CDS 739895..741004 /gene="flvM" /locus_tag="BSU_07230" /old_locus_tag="BSU07230" /EC_number="1.14.13.-" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 25209494; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative flavin-dependent hydroxylase/monooxygenase acting on salicylate derivatives" /protein_id="NP_388604.1" /db_xref="EnsemblGenomes-Gn:BSU07230" /db_xref="EnsemblGenomes-Tr:CAB12542" /db_xref="GOA:O06489" /db_xref="InterPro:IPR002938" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG12869" /db_xref="UniProtKB/Swiss-Prot:O06489" /translation="MKHMLIAGGGIGGLSAAISLRKAGFSVTLCEAASENRKTGAGIL QPQNALAVLKELGVFEDCCKHGFQTEWFKTFDEQGNLLFQVSESFLDDSLPGRNNILR KTLNDILMKHAEAVGVDIKWGKKVVAYEETAESVTALCEDGEKMQADILAGFDGIHSV VRDKMLQKETEKEHLGMGAWRFYIELPDYTFEDATFMYRSGDTQIGVVPLAQHAGYVF VLQPCTSDYWDEEDTRFDRVKEILSGFRGLDFVTKHMSKQHPVIFNKLEQVAVQEPWH KGRVIIGGDAAHAGAPTLAQGAAMAIEDAIVLAEELQNHADHETALQAYYKRRAPRAL KVQNLSSEIVRRRLKGEPGAEELIGECYAVLREGY*" /label="flvM CDS" gene 739895..741004 /gene="flvM" /locus_tag="BSU_07230" /old_locus_tag="BSU07230" /label="flvM gene" downshifts 740987 /Source="Nicolas_upshifts" /id="D354" /incds=0 /nref=7 /ntot=67 /MaxReadThrough="0.0953400000000002" /MaxDrop="5.1482" /score="13.261567" /energy="-12.6" /TU="NA" /idTUdmin="U542" /TUdmin=1804 /isTUend="FALSE" /label="downshifts" CDS complement(741039..742109) /gene="yetN" /locus_tag="BSU_07240" /old_locus_tag="BSU07240" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22333191" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388605.1" /db_xref="EnsemblGenomes-Gn:BSU07240" /db_xref="EnsemblGenomes-Tr:CAB12543" /db_xref="InterPro:IPR025006" /db_xref="InterPro:IPR025012" /db_xref="SubtiList:BG12870" /db_xref="UniProtKB/Swiss-Prot:O06490" /translation="MDFEIRFLSFYVIQVEGKDEQANKQFKHFQTLDTGEFEESELKD FLDGELKKIVKRKADRHPQSEQVPTKIGHFIVEPGHELDSNPNYNMFNRARLAETKED FNELSEQFVRTYLDTSAVRGGVFLVASAVPRKYFDESFVFIMKCDFEPKVARISDASS LIKKVEMAITTKNMKSIQYPYMPEEGMVEEGELKIHQASHARYFEDFLKFVEYGESMP EIMKNQVMNMVQEHVYETFEDNSEELKQFEHDIEIWEASEKREIQERLDTHQVIEASA QIIEHTPEAQLKMKVGETEIKGLLADFGDSIHLAKVNGRYVALIEAETISFEKGSSPV EFYKPEGLHEVIERIRNKTEQD*" /label="yetN CDS" gene complement(741039..742109) /gene="yetN" /locus_tag="BSU_07240" /old_locus_tag="BSU07240" /label="yetN gene" downshifts complement(741063) /Source="Nicolas_upshifts" /id="D355" /incds=0 /nref=45 /ntot=180 /MaxReadThrough="0.83729" /MaxDrop="4.28938" /score="0.323038441" /energy="-11.6" /TU="NA" /idTUdmin="U545" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(742140..742159) /Source="Nicolas_upshift_promotors" /id="U545" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.818181818181818" /psig="0.987012987012987" /xcortree=1835 /SigmaFactorBS="atttgactacatttccctttcatggtcatgattattccgttc tccCAATTGACgcatgatcgctgttTTTTCTATACTTGAGAAGCTgtacaatacgcga a" /listShort="yetN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(742166) /Source="Nicolas_upshifts" /id="U545" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.818181818181818" /psig="0.987012987012987" /xcortree=1835 /SigmaFactorBS="atttgactacatttccctttcatggtcatgattattccgttc tccCAATTGACgcatgatcgctgttTTTTCTATACTTGAGAAGCTgtacaatacgcga a" /listShort="yetN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(742174..742181) /Source="Nicolas_upshift_promotors" /id="U545" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.818181818181818" /psig="0.987012987012987" /xcortree=1835 /SigmaFactorBS="atttgactacatttccctttcatggtcatgattattccgttc tccCAATTGACgcatgatcgctgttTTTTCTATACTTGAGAAGCTgtacaatacgcga a" /listShort="yetN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 742189..742195 /Source="Nicolas_upshift_promotors" /id="U546" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=728 /SigmaFactorBS="aaacagcgatcatgcgtcaattgggagaacGGAATAAtcatg accatgaaaGGGAAATGTAGTCAAATAGaaggcatttcatacggaaaggaatggttcg a" /listShort="yetO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 742210..742228 /Source="Nicolas_upshift_promotors" /id="U546" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=728 /SigmaFactorBS="aaacagcgatcatgcgtcaattgggagaacGGAATAAtcatg accatgaaaGGGAAATGTAGTCAAATAGaaggcatttcatacggaaaggaatggttcg a" /listShort="yetO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 742219 /Source="Nicolas_upshifts" /id="U546" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=728 /SigmaFactorBS="aaacagcgatcatgcgtcaattgggagaacGGAATAAtcatg accatgaaaGGGAAATGTAGTCAAATAGaaggcatttcatacggaaaggaatggttcg a" /listShort="yetO" /GFF_Attribute="listLong" /label="upshifts" CDS 742259..745444 /gene="cypD" /locus_tag="BSU_07250" /old_locus_tag="BSU07250" /EC_number="1.6.2.4" /EC_number="1.14.14.1" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11574077, 2544578, 21048857, 26452461; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional P-450/NADPH-P450 reductase 1" /protein_id="NP_388606.1" /db_xref="EnsemblGenomes-Gn:BSU07250" /db_xref="EnsemblGenomes-Tr:CAB12544" /db_xref="GOA:O08394" /db_xref="InterPro:IPR001094" /db_xref="InterPro:IPR001128" /db_xref="InterPro:IPR001433" /db_xref="InterPro:IPR001709" /db_xref="InterPro:IPR003097" /db_xref="InterPro:IPR008254" /db_xref="InterPro:IPR017927" /db_xref="InterPro:IPR017938" /db_xref="InterPro:IPR017972" /db_xref="InterPro:IPR023206" /db_xref="InterPro:IPR029039" /db_xref="InterPro:IPR036396" /db_xref="SubtiList:BG12871" /db_xref="UniProtKB/Swiss-Prot:O08394" /translation="MKETSPIPQPKTFGPLGNLPLIDKDKPTLSLIKLAEEQGPIFQI HTPAGTTIVVSGHELVKEVCDEERFDKSIEGALEKVRAFSGDGLFTSWTHEPNWRKAH NILMPTFSQRAMKDYHEKMVDIAVQLIQKWARLNPNEAVDVPGDMTRLTLDTIGLCGF NYRFNSYYRETPHPFINSMVRALDEAMHQMQRLDVQDKLMVRTKRQFRYDIQTMFSLV DSIIAERRANGDQDEKDLLARMLNVEDPETGEKLDDENIRFQIITFLIAGHETTSGLL SFATYFLLKHPDKLKKAYEEVDRVLTDAAPTYKQVLELTYIRMILNESLRLWPTAPAF SLYPKEDTVIGGKFPITTNDRISVLIPQLHRDRDAWGKDAEEFRPERFEHQDQVPHHA YKPFGNGQRACIGMQFALHEATLVLGMILKYFTLIDHENYELDIKQTLTLKPGDFHIS VQSRHQEAIHADVQAAEKAAPDEQKEKTEAKGASVIGLNNRPLLVLYGSDTGTAEGVA RELADTASLHGVRTKTAPLNDRIGKLPKEGAVVIVTSSYNGKPPSNAGQFVQWLQEIK PGELEGVHYAVFGCGDHNWASTYQYVPRFIDEQLAEKGATRFSARGEGDVSGDFEGQL DEWKKSMWADAIKAFGLELNENADKERSTLSLQFVRGLGESPLARSYEASHASIAENR ELQSADSDRSTRHIEIALPPDVEYQEGDHLGVLPKNSQTNVSRILHRFGLKGTDQVTL SASGRSAGHLPLGRPVSLHDLLSYSVEVQEAATRAQIRELASFTVCPPHRRELEELSA EGVYQEQILKKRISMLDLLEKYEACDMPFERFLELLRPLKPRYYSISSSPRVNPRQAS ITVGVVRGPAWSGRGEYRGVASNDLAERQAGDDVVMFIRTPESRFQLPKDPETPIIMV GPGTGVAPFRGFLQARDVLKREGKTLGEAHLYFGCRNDRDFIYRDELERFEKDGIVTV HTAFSRKEGMPKTYVQHLMADQADTLISILDRGGRLYVCGDGSKMAPDVEAALQKAYQ AVHGTGEQEAQNWLRHLQDTGMYAKDVWAGI*" /label="cypD CDS" gene 742259..745444 /gene="cypD" /locus_tag="BSU_07250" /old_locus_tag="BSU07250" /label="cypD gene" downshifts 745431 /Source="Nicolas_upshifts" /id="D356" /incds=0 /nref=1 /ntot=9 /MaxReadThrough="2.31156" /MaxDrop="2.91666" /score="9.17315362" /energy="-9.8" /TU="NA" /idTUdmin="U546" /TUdmin=44 /isTUend="FALSE" /label="downshifts" promotor_-35 745494..745499 /Source="Nicolas_upshift_promotors" /id="U547" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.841158841158841" /psig="0.841158841158841" /xcortree=1029 /SigmaFactorBS="agtcctttcgaaaaaatgGTGATCgcgctaaacattgatGCA TACAATAACTTCAGTCcgccggaagggcgggctgtctgcaaaacctatttttcgtttt t" /listShort="S250, ltaSA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 745515..745533 /Source="Nicolas_upshift_promotors" /id="U547" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.841158841158841" /psig="0.841158841158841" /xcortree=1029 /SigmaFactorBS="agtcctttcgaaaaaatgGTGATCgcgctaaacattgatGCA TACAATAACTTCAGTCcgccggaagggcgggctgtctgcaaaacctatttttcgtttt t" /listShort="S250, ltaSA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 745536 /Source="Nicolas_upshifts" /id="U547" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.841158841158841" /psig="0.841158841158841" /xcortree=1029 /SigmaFactorBS="agtcctttcgaaaaaatgGTGATCgcgctaaacattgatGCA TACAATAACTTCAGTCcgccggaagggcgggctgtctgcaaaacctatttttcgtttt t" /listShort="S250, ltaSA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 745564..745567 /Source="Nicolas_upshift_promotors" /id="U548" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.803196803196803" /psig=1 /xcortree=2603 /SigmaFactorBS="acttcagtccgccggaagggcgggctgtctgcaaaacctATT TttcgtttttgctagttTATGTTATTCTTATACTCGGtatctatttcttttttcaaag g" /listShort="S250, ltaSA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 745584..745603 /Source="Nicolas_upshift_promotors" /id="U548" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.803196803196803" /psig=1 /xcortree=2603 /SigmaFactorBS="acttcagtccgccggaagggcgggctgtctgcaaaacctATT TttcgtttttgctagttTATGTTATTCTTATACTCGGtatctatttcttttttcaaag g" /listShort="S250, ltaSA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 745585..745890 /Source="Nicolas_S_feature" /locus_tag="new_796008_796313" /HighExp="H2O2, Paraq, Oxctl, Cold, Heat, LBGexp, G180, G150, HPh, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="1, 0.841" /TUlongSig="NA" /TUlongPSig="NA" /label="S250" upshifts 745585 /Source="Nicolas_upshifts" /id="U548" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.803196803196803" /psig=1 /xcortree=2603 /SigmaFactorBS="acttcagtccgccggaagggcgggctgtctgcaaaacctATT TttcgtttttgctagttTATGTTATTCTTATACTCGGtatctatttcttttttcaaag g" /listShort="S250, ltaSA" /GFF_Attribute="listLong" /label="upshifts" CDS 745891..747810 /gene="ltaSA" /locus_tag="BSU_07260" /old_locus_tag="BSU07260" /function="16.1: Circulate" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11544192, 15187182, 17434969, 17483484, 21255105, 27002131; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="exported glycerol phosphate lipoteichoic acid synthetase and anion-binding protein" /protein_id="NP_388607.2" /db_xref="EnsemblGenomes-Gn:BSU07260" /db_xref="EnsemblGenomes-Tr:CAB12545" /db_xref="GOA:Q797B3" /db_xref="InterPro:IPR000917" /db_xref="InterPro:IPR012160" /db_xref="InterPro:IPR017849" /db_xref="InterPro:IPR017850" /db_xref="SubtiList:BG12980" /db_xref="UniProtKB/Swiss-Prot:Q797B3" /translation="MKKLFSYKLSFFVLAVILFWAKTYLSYKTEFNLGVKGTTQEILL IFNPFSSAVFFLGLALLAKGRKSAIIMLIIDFLMTFVLYANILFYRFFDDFLTFPNIK QSGNVGNMGDGIFSIMAGHDIFYFLDIIILIAVLIWRPELKEYKMKKRFASLVILSGI ALFFINLHYAEKDRPQLLTRTFDRNYIVKYLGLYNYTIYDGVQTAQTETQRAYASSDD LTSVENYTTSHYAKPNAEYFGSAKGKNIIKIHLESFQSFLIDYKLNGEEVTPFLNKLA HGGEDVTYFDNFFHQTGQGKTSDAELTMDNSIFGLPEGSAFVTKGENTYQSLPAILDQ KEGYTSAVLHGDYKSFWNRDQIYKHIGYDKFFDASTYDMSDENVINMGLKDKPFFTES IPKLESLKQPFYAHLITLTNHYPFNLDEKDASLKKATTGDNTVDSYFQTARYLDEALE QFFKELKEAGLYDNSVIMIYGDHNGISENHNRAMKEILGKEITDYQNAQNQRVPLMIR VPGKKGGVNHTYGGEIDVMPTLLHLEGIDSQKYINFGTDLFSKDHDDTVAFRNGDFVT PKYTSVDNIIYDTKTGEKLKANEETKNLKTRVNQQLSLSDSVLYKDLLRFHKLNDFKA VDPSDYHYGKEKEIK*" /label="ltaSA CDS" gene 745891..747810 /gene="ltaSA" /locus_tag="BSU_07260" /old_locus_tag="BSU07260" /label="ltaSA gene" downshifts 747809 /Source="Nicolas_upshifts" /id="D357" /incds=0 /nref=103 /ntot=261 /MaxReadThrough="1.69168" /MaxDrop="7.8227" /score="37.7648461" /energy="-24" /TU="NA" /idTUdmin="U547" /TUdmin=2 /isTUend="TRUE" /label="downshifts" promotor_-35 747898..747907 /Source="Nicolas_upshift_promotors" /id="U549" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1421 /SigmaFactorBS="tttttttggttatacaaccaacttgaaaaaatagattccatT TGGTCACCAaggctggctttctCTCATATCATTACAGTAGATtttgaaaccggattga a" /listShort="S251, yfnH, yfnG, yfnF, yfnE, yfnD" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 747917..748045 /Source="Nicolas_S_feature" /locus_tag="new_798340_798468" /HighExp="BT, B36, S8, S7, G/S, Pyr, B60, S6, Glucon, MG 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S251" upshifts 747917 /Source="Nicolas_upshifts" /id="U549" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1421 /SigmaFactorBS="tttttttggttatacaaccaacttgaaaaaatagattccatT TGGTCACCAaggctggctttctCTCATATCATTACAGTAGATtttgaaaccggattga a" /listShort="S251, yfnH, yfnG, yfnF, yfnE, yfnD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 747921..747940 /Source="Nicolas_upshift_promotors" /id="U549" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1421 /SigmaFactorBS="tttttttggttatacaaccaacttgaaaaaatagattccatT TGGTCACCAaggctggctttctCTCATATCATTACAGTAGATtttgaaaccggattga a" /listShort="S251, yfnH, yfnG, yfnF, yfnE, yfnD" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(747971) /Source="Nicolas_upshifts" /id="D358" /incds=0 /nref=2 /ntot=6 /MaxReadThrough="1.80969" /MaxDrop="4.63324" /score="20.6569889" /energy="-23.4" /TU="NA" /idTUdmin="U552" /TUdmin=4928 /isTUend="FALSE" /label="downshifts" CDS 748046..748810 /gene="spmH" /locus_tag="BSU_07270" /old_locus_tag="BSU07270" /EC_number="2.7.7.33" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15634670, 16357223, 26577401" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15634670, 16357223, 26577401; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucose-1-phosphate cytidylyltransferase (sporulation)" /protein_id="NP_388608.1" /db_xref="EnsemblGenomes-Gn:BSU07270" /db_xref="EnsemblGenomes-Tr:CAB12546" /db_xref="GOA:O06486" /db_xref="InterPro:IPR005835" /db_xref="InterPro:IPR013446" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG12979" /db_xref="UniProtKB/Swiss-Prot:O06486" /translation="MKAVILCGGKGTRMSEVTNDIPKPLAMIGGKPILWHIMKIYQYY GVNEFILLLGYKGEKIKEYFLDYEWKHNSLTLDSSTGEVQMLGQPETWKITFLETGVD TLTAGRILQAKDYIGDETFLLTYGDGLANINLFHLISYHQTKGAAATVTGIDKVSQFG TLTVEDGMAKTFSEKTSSDGIINGGFFVLSPKVFDYLPKDGNTMFEDEPLKNLAKDGE LAVYRHYGFWTAIDTYKNLLEVNKMWNQGQQVWKVW*" /label="spmH CDS" gene 748046..748810 /gene="spmH" /locus_tag="BSU_07270" /old_locus_tag="BSU07270" /label="spmH gene" CDS 748817..749785 /gene="spmG" /locus_tag="BSU_07280" /old_locus_tag="BSU07280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative CDP-sugar-dehydratase/epimerase" /protein_id="NP_388609.2" /db_xref="EnsemblGenomes-Gn:BSU07280" /db_xref="EnsemblGenomes-Tr:CAB12547" /db_xref="GOA:O06485" /db_xref="InterPro:IPR016040" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12978" /db_xref="UniProtKB/Swiss-Prot:O06485" /translation="MSFWKNKNVFVTGCTGLLGSYLVKELIEQGANVTGLVRDHVPQS NLYQGEHIKKMNIVRGSLEDLAVIERALGEYEIDTVFHLAAQAIVGVANRNPISTFEA NILGTWNILEACRKHPLIKRVIVASSDKAYGDQENLPYDENMPLQGKHPYDVSKSCAD LISHTYFHTYGLPVCITRCGNLYGGGDLNFNRIIPQTIQLVLNGEAPEIRSDGTFVRD YFYIEDAVQAYLLLAEKMEENNLAGEAFNFSNEIQLTVLELVEKILKKMNSNLKPKVL NQGSNEIKHQYLSAEKARKLLNWTPAYTIDEGLEKTIEWYTEFFKK*" /label="spmG CDS" gene 748817..749785 /gene="spmG" /locus_tag="BSU_07280" /old_locus_tag="BSU07280" /label="spmG gene" CDS 749809..750720 /gene="yfnF" /locus_tag="BSU_07290" /old_locus_tag="BSU07290" /EC_number="2.4.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_388610.1" /db_xref="EnsemblGenomes-Gn:BSU07290" /db_xref="EnsemblGenomes-Tr:CAB12548" /db_xref="InterPro:IPR005069" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG12977" /db_xref="UniProtKB/Swiss-Prot:O06484" /translation="MTSAYCTVLSKGRLYQAVALFKSLEQVDQDSPIFILCMDEDTHR VLQKLKMKQLNLVPVAALENELLLKLKETRDQSEYCWTMKPIFLQAVLNSNPELERVT YIDGDLFFYADPSPIFENQPDCSVLLSRGDIVIPSFEKEQIDMLQRLLGRYNSGFISF KHDDAGTDCLEWWKERCLEECKNAPGEGKFGDQGYLDYMSELFPNVCDITTPGVNIGH WNYGQHTFSWKDGRIVLEDGSPLIFYHFSGYRIVSINEIKQIHETTRTDLPFVHELYQ ETLPHIIQHMQTLDPEFNGFASKDDNK*" /label="yfnF CDS" gene 749809..750720 /gene="yfnF" /locus_tag="BSU_07290" /old_locus_tag="BSU07290" /label="yfnF gene" promotor_-35 750598..750607 /Source="Nicolas_upshift_promotors" /id="U550" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1259 /SigmaFactorBS="tcagcatcaatgaaatcaaacagattcatgaaacaACCCGCA CAGatctgccgtttgTGCATGAACTGTATCAAGAGacactgccgcatatcattcagca c" /listShort="yfnE, yfnD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 750620..750639 /Source="Nicolas_upshift_promotors" /id="U550" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1259 /SigmaFactorBS="tcagcatcaatgaaatcaaacagattcatgaaacaACCCGCA CAGatctgccgtttgTGCATGAACTGTATCAAGAGacactgccgcatatcattcagca c" /listShort="yfnE, yfnD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 750623 /Source="Nicolas_upshifts" /id="U550" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1259 /SigmaFactorBS="tcagcatcaatgaaatcaaacagattcatgaaacaACCCGCA CAGatctgccgtttgTGCATGAACTGTATCAAGAGacactgccgcatatcattcagca c" /listShort="yfnE, yfnD" /GFF_Attribute="listLong" /label="upshifts" CDS 750749..751927 /gene="yfnE" /locus_tag="BSU_07300" /old_locus_tag="BSU07300" /EC_number="2.4.1.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase (complex carbohydrate synthase)" /protein_id="NP_388611.1" /db_xref="EnsemblGenomes-Gn:BSU07300" /db_xref="EnsemblGenomes-Tr:CAB12549" /db_xref="GOA:O06483" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG12976" /db_xref="UniProtKB/Swiss-Prot:O06483" /translation="MKASVIIPAYNSKERLYNSLLSLNQQECDEEFEVIVADNGSEDG TLSMLESFQADFPLIFTRIKENRGIAYGRNQALRNARGDILIFHDSDMLAAKDLVAKH IKAHENEENLVVCGLFWKRIYSFYYERFEEEHKEQLAKLTGEMPKKDKQKLLEEADIK NGSFLDKSFDLDTDFIDVLKKILDEYGDDLKGYHMPWRFFITNNSSVKRKHVVDLGLF DEGIVRYGFEDYDLGIRLHQAGLTFRLRRDIVSVHQEHPSNCKSVDDIRANIAYMCDK YNNIRSLDVHLAFNGPFPPDMTNRIMADIQKLLESQKYDMLLNLFLELLHVVKERNID PDWRKKSPRVTAKSFDLQTVRKLLPKAKKKLGVNDFANALYALVNDLLHVDLRSLDVV *" /label="yfnE CDS" gene 750749..751927 /gene="yfnE" /locus_tag="BSU_07300" /old_locus_tag="BSU07300" /label="yfnE gene" promotor_-35 751468..751474 /Source="Nicolas_upshift_promotors" /id="U551" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.383616383616384" /psig="0.913086913086913" /xcortree=307 /SigmaFactorBS="tcgggatcaggcttcatcaggccggATTGACCttcaggcttc gccgTGATATTGTCAGTGTTCATCaggaacatccaagcaattgtaagtctgtagacga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 751489..751508 /Source="Nicolas_upshift_promotors" /id="U551" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.383616383616384" /psig="0.913086913086913" /xcortree=307 /SigmaFactorBS="tcgggatcaggcttcatcaggccggATTGACCttcaggcttc gccgTGATATTGTCAGTGTTCATCaggaacatccaagcaattgtaagtctgtagacga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 751503 /Source="Nicolas_upshifts" /id="U551" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.383616383616384" /psig="0.913086913086913" /xcortree=307 /SigmaFactorBS="tcgggatcaggcttcatcaggccggATTGACCttcaggcttc gccgTGATATTGTCAGTGTTCATCaggaacatccaagcaattgtaagtctgtagacga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 751928..752863 /gene="yfnD" /locus_tag="BSU_07310" /old_locus_tag="BSU07310" /EC_number="2.4.1.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase (complex carbohydrate synthase)" /protein_id="NP_388612.1" /db_xref="EnsemblGenomes-Gn:BSU07310" /db_xref="EnsemblGenomes-Tr:CAB12550" /db_xref="InterPro:IPR005069" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG12975" /db_xref="UniProtKB/Swiss-Prot:O31542" /translation="MSTFHFSTIVSRTHIFKLMPMIHSLHEHCDDFHLYVLCVDQKAY ELLQHVPWEHVTFVQLHEMEDPELLKAKSNRTFHEYCWTLKPAFLFHVMSKWDDAEYF AHMDTDLFFFSDPARIFAENPTASLYLTDHRNSPRFMSYYDRTGRFNTGFVGAGNTKE AYEAVWQWRQDCIEFCTVEMDTERKTYGDQRYVEKWPEQFKGVHVVKSIGANTALWNI ENYKVGQKDGRVYIDETPLIFYHFSGFTLVTEKEFNLCWYYRIEDEATIKMIYMPYIL NLKRWIDEIQSAFPDFADGFIPKHAVPDTHFIQLD*" /label="yfnD CDS" gene 751928..752863 /gene="yfnD" /locus_tag="BSU_07310" /old_locus_tag="BSU07310" /label="yfnD gene" downshifts 752735 /Source="Nicolas_upshifts" /id="D359" /incds=1 /nref=1 /ntot=52 /MaxReadThrough="5.41459" /MaxDrop="2.6465" /score="34.8532284" /energy="-15.2" /TU="U549,U550" /idTUdmin="U549" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" downshifts 752845 /Source="Nicolas_upshifts" /id="D360" /incds=0 /nref=2 /ntot=30 /MaxReadThrough="2.32849" /MaxDrop="5.65066" /score="34.8532284" /energy="-15.2" /TU="NA" /idTUdmin="U549" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(752886) /Source="Nicolas_upshifts" /id="D361" /incds=0 /nref=158 /ntot=249 /MaxReadThrough="1.15199" /MaxDrop="4.97014" /score="32.9697757" /energy="-15.2" /TU="NA" /idTUdmin="U552" /TUdmin=13 /isTUend="TRUE" /label="downshifts" CDS complement(752894..754123) /gene="yfnC" /locus_tag="BSU_07320" /old_locus_tag="BSU07320" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388613.1" /db_xref="EnsemblGenomes-Gn:BSU07320" /db_xref="EnsemblGenomes-Tr:CAB12551" /db_xref="GOA:O06481" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12974" /db_xref="UniProtKB/Swiss-Prot:O06481" /translation="MAIAAPLKEKTVQKPGTTVYPILIIIGICHMLNDSLQAVIPAMF PILERSMSLTFTQLGIIAFTLNMVSSVMQPVVGWYTDKRPRPYALPVGLTASMLGILG LAFAPSFITILCCVFFIGLGSAIFHPEGSRVAYMAAGTKRGLAQSIYQVGGNSGQAMA PLITALILVPLGQFGAVWFTLVAALAVMFLMYIAKWYASRLGSLAQKSGKQKKTAENT AITKSVVSALIIIIFLIFARSWYTSAIGNFYTFYAMDTYHVSIQQAQSYIFVFLLFGA IGTFLGGPLADRFGKRFVILGSLLCSAPLAIVLPFAGPVLAYGVLALIGLVLMSSFSV TVVYAQELVPGKIGTMSGLTVGLAFGMGAIGAVALGALIDAAGLTPTMIAIAFLPVLG ILAFLLPSDQKLREWHS*" /label="yfnC CDS" gene complement(752894..754123) /gene="yfnC" /locus_tag="BSU_07320" /old_locus_tag="BSU07320" /label="yfnC gene" promotor_-10 complement(754152..754171) /Source="Nicolas_upshift_promotors" /id="U552" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.909090909090909" /psig="0.997002997002997" /xcortree=2717 /SigmaFactorBS="ggctgacggtatttctttcataagaatcttttttccTCTTGA TAaattcttcaccttatGAATAATATGGTGGTATGCTttggttatatatgtaaggagg a" /listShort="yfnC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(754170) /Source="Nicolas_upshifts" /id="U552" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.909090909090909" /psig="0.997002997002997" /xcortree=2717 /SigmaFactorBS="ggctgacggtatttctttcataagaatcttttttccTCTTGA TAaattcttcaccttatGAATAATATGGTGGTATGCTttggttatatatgtaaggagg a" /listShort="yfnC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(754187..754194) /Source="Nicolas_upshift_promotors" /id="U552" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.909090909090909" /psig="0.997002997002997" /xcortree=2717 /SigmaFactorBS="ggctgacggtatttctttcataagaatcttttttccTCTTGA TAaattcttcaccttatGAATAATATGGTGGTATGCTttggttatatatgtaaggagg a" /listShort="yfnC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(754234..754941) /gene="pynN" /locus_tag="BSU_07330" /old_locus_tag="BSU07330" /EC_number="3.1.3.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyrimidine nucleotide phosphatase (promiscuous)" /protein_id="NP_388614.1" /db_xref="EnsemblGenomes-Gn:BSU07330" /db_xref="EnsemblGenomes-Tr:CAB12552" /db_xref="GOA:O06480" /db_xref="InterPro:IPR006439" /db_xref="InterPro:IPR011951" /db_xref="InterPro:IPR023198" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="PDB:3ED5" /db_xref="PDB:3I76" /db_xref="SubtiList:BG12973" /db_xref="UniProtKB/Swiss-Prot:O06480" /translation="MKRYRTLLFDVDDTILDFQAAEALALRLLFEDQNIPLTNDMKAQ YKTINQGLWRAFEEGKMTRDEVVNTRFSALLKEYGYEADGALLEQKYRRFLEEGHQLI DGAFDLISNLQQQFDLYIVTNGVSHTQYKRLRDSGLFPFFKDIFVSEDTGFQKPMKEY FNYVFERIPQFSAEHTLIIGDSLTADIKGGQLAGLDTCWMNPDMKPNVPEIIPTYEIR KLEELYHILNIENTVSC*" /label="pynN CDS" gene complement(754234..754941) /gene="pynN" /locus_tag="BSU_07330" /old_locus_tag="BSU07330" /label="pynN gene" downshifts complement(754263) /Source="Nicolas_upshifts" /id="D362" /incds=0 /nref=25 /ntot=169 /MaxReadThrough="2.75071" /MaxDrop="4.28644" /score="1.09492978" /energy="-15.7" /TU="NA" /idTUdmin="U553" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(754964..754983) /Source="Nicolas_upshift_promotors" /id="U553" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.985014985014985" /psig="0.998001998001998" /xcortree=3118 /SigmaFactorBS="ttattaaacaaataatctcttttcagccggcggtgcctcacc cgccggctttttcctttttttaTGTGCTATACTTTGAATACAtatgagaaagggagac a" /listShort="yfnB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(754987) /Source="Nicolas_upshifts" /id="U553" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.985014985014985" /psig="0.998001998001998" /xcortree=3118 /SigmaFactorBS="ttattaaacaaataatctcttttcagccggcggtgcctcacc cgccggctttttcctttttttaTGTGCTATACTTTGAATACAtatgagaaagggagac a" /listShort="yfnB" /GFF_Attribute="listLong" /label="upshifts" CDS complement(755033..756418) /gene="mtrA" /locus_tag="BSU_07340" /old_locus_tag="BSU07340" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12022921, 15849754, 16850406, 17114254, 18632116" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12022921, 15849754, 16850406, 17114254, 18632116; Product type t : transporter" /codon_start=1 /transl_table=11 /product="methylthioribose permease" /protein_id="NP_388615.1" /db_xref="EnsemblGenomes-Gn:BSU07340" /db_xref="EnsemblGenomes-Tr:CAB12553" /db_xref="GOA:Q797A7" /db_xref="InterPro:IPR002293" /db_xref="SubtiList:BG12972" /db_xref="UniProtKB/Swiss-Prot:Q797A7" /translation="MSSLFRKKPLETLSAQSKSKSLARTLSAFDLTLLGIGCVIGTGI FVITGTVAATGAGPALIISFILAGLACALAAFCYAEFSSSIPISGSVYSYSYVTLGEL LAFLIGWDLMLEYVIALSAVATGWSSYFQSLLAGFNLHIPAALTGAPGSMAGAVFNLP AAVIILLITAIVSRGVKESTRFNNVIVLMKIAIILLFIIVGIGYVKPDNWSPFMPFGM KGVILSAATVFFAYLGFDAVSNASEEVKNPQKNMPVGIISALAVCTVLYIAVSLVLTG MMPYAKLNVGDPVSFALKFVGQDAVAGIISVGAIIGITTVMLALLYAQVRLTFAMSRD GLLPGLFAKVHPSFKTPFRNTWLTGIVAAGIAGFINLGTLAHLVNMGTLAAFTVISIA VIVLRKKHPEIKASFRVPFVPVVPIISAGICLWFMYSLPGVTWLSFVIWIAVGTLVYF LYSRKHSLLNK*" /label="mtrA CDS" gene complement(755033..756418) /gene="mtrA" /locus_tag="BSU_07340" /old_locus_tag="BSU07340" /label="mtrA gene" downshifts complement(755055) /Source="Nicolas_upshifts" /id="D363" /incds=0 /nref=8 /ntot=91 /MaxReadThrough="3.68565" /MaxDrop="4.73728" /score="31.1617384" /energy="-15.4" /TU="U554" /idTUdmin="U554" /TUdmin="-770" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(756467..756486) /Source="Nicolas_upshift_promotors" /id="U554" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.913086913086913" /psig=1 /xcortree=2397 /SigmaFactorBS="tgtttcgcttctatcatttaaagcagaaaaatatttTATTGA CTacgtcaaatttcgaCAATATAATACAACAAGAACtgcatataatgattagaatatt t" /listShort="yfnA, yfnB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(756484) /Source="Nicolas_upshifts" /id="U554" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.913086913086913" /psig=1 /xcortree=2397 /SigmaFactorBS="tgtttcgcttctatcatttaaagcagaaaaatatttTATTGA CTacgtcaaatttcgaCAATATAATACAACAAGAACtgcatataatgattagaatatt t" /listShort="yfnA, yfnB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(756501..756508) /Source="Nicolas_upshift_promotors" /id="U554" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.913086913086913" /psig=1 /xcortree=2397 /SigmaFactorBS="tgtttcgcttctatcatttaaagcagaaaaatatttTATTGA CTacgtcaaatttcgaCAATATAATACAACAAGAACtgcatataatgattagaatatt t" /listShort="yfnA, yfnB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 756586..756593 /Source="Nicolas_upshift_promotors" /id="U555" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2800 /SigmaFactorBS="aacagcgttgtcgtatcataggatagtaatttttactaatcg tatATTCAATTttatgcaagatgaACCGATAGAAAAAATAGATtcgcccatattttga t" /listShort="yfmT, yfmS" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 756601 /Source="Nicolas_upshifts" /id="U555" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2800 /SigmaFactorBS="aacagcgttgtcgtatcataggatagtaatttttactaatcg tatATTCAATTttatgcaagatgaACCGATAGAAAAAATAGATtcgcccatattttga t" /listShort="yfmT, yfmS" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 756607..756625 /Source="Nicolas_upshift_promotors" /id="U555" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2800 /SigmaFactorBS="aacagcgttgtcgtatcataggatagtaatttttactaatcg tatATTCAATTttatgcaagatgaACCGATAGAAAAAATAGATtcgcccatattttga t" /listShort="yfmT, yfmS" /GFF_Attribute="listLong" /label="promotor_-10" CDS 756668..758125 /gene="vdhT" /locus_tag="BSU_07350" /old_locus_tag="BSU07350" /EC_number="1.2.1.67" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 15033535, 26658822; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="vanillin dehydrogenase" /protein_id="NP_388616.1" /db_xref="EnsemblGenomes-Gn:BSU07350" /db_xref="EnsemblGenomes-Tr:CAB12554" /db_xref="GOA:O06478" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="SubtiList:BG12971" /db_xref="UniProtKB/Swiss-Prot:O06478" /translation="MFQYEELNKQFIGGKWQEGSSPNVLENKNPYTQKTFTTFRKATA DDVDEAYRAAALAKKKWDAVNPFEKRTILEKAVTYIEENEEAIIYLIMEELGGTRLKA AFEIGLVKNIIKEAATFPIRMEGKILPSTIDGKENRLYRVPAGVVGVISPFNFPFFLS MKSVAPALGAGNGVVLKPHEETPICGGTLIAKIFENAGIPAGLLNVVVTDIAEIGDSF VEHPVPRIISFTGSTKVGSYIGQLAMKHFKKPLLELGGNSAFIVLEDADIEYAVNAAV FSRFTHQGQICMSANRVLVHSSIYDKFLELYQAKVESLKVGDPMDPDTIIGPLINSRQ TDGLMKTVEQAIEEGAVPVKLGGFNGTIVEPTILKDVKPFMSIAKEELFGPVVSFMKF DSEDEAVDIANETPFGLSGAVHTSNLERGVAFAKRIETGMIHVNDTTINDEPNVAFGG EKQSGLGRLNGEWSLEEFTTLKWISVQHEKRSFPY*" /label="vdhT CDS" gene 756668..758125 /gene="vdhT" /locus_tag="BSU_07350" /old_locus_tag="BSU07350" /label="vdhT gene" promotor_-10 complement(757461..757480) /Source="Nicolas_upshift_promotors" /id="U556" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1237 /SigmaFactorBS="ctgacatgcaaatctgcccttgatgtgtaaatcGGCTGAACA CcgccgcattgacCGCATATTCTATATCTGCATcctcaagtacgatgaaggcgctgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(757475) /Source="Nicolas_upshifts" /id="U556" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1237 /SigmaFactorBS="ctgacatgcaaatctgcccttgatgtgtaaatcGGCTGAACA CcgccgcattgacCGCATATTCTATATCTGCATcctcaagtacgatgaaggcgctgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(757493..757502) /Source="Nicolas_upshift_promotors" /id="U556" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1237 /SigmaFactorBS="ctgacatgcaaatctgcccttgatgtgtaaatcGGCTGAACA CcgccgcattgacCGCATATTCTATATCTGCATcctcaagtacgatgaaggcgctgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 758139..758999 /gene="yfmS" /locus_tag="BSU_07360" /old_locus_tag="BSU07360" /function="16.5: Explore" /function="16.3: Control" /function="16.12: Sense" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15033535, 27899502; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="chemotaxis sensory transducer (sensed target unknown)" /protein_id="NP_388617.1" /db_xref="EnsemblGenomes-Gn:BSU07360" /db_xref="EnsemblGenomes-Tr:CAB12555" /db_xref="GOA:O06477" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR029151" /db_xref="SubtiList:BG12970" /db_xref="UniProtKB/Swiss-Prot:O06477" /translation="MELTINTEKETADILDAFIKVAPYLNSLVQDDITIGIYDTEKLL VNIPAKTFSLNVKAGDPLQEGDIITDAIRSNQKKTSMVPKELFGFPLIARAIPLHDEN GRVIGGVGLGTSLEESSKLHDVAESLSAVVEQTAAAISDISESINGFSTQMSGISSQA KKVSESAGEIADISVTVKGISDQSNLLGLNAAIEAARAGESGKGFSVVADEIRKLATH SKENVGQIDQITKKIHSLLKGLEESIESINQHTDGQAAAVEQISATMQEISGSAQHLA KMAEKALEEE*" /label="yfmS CDS" gene 758139..758999 /gene="yfmS" /locus_tag="BSU_07360" /old_locus_tag="BSU07360" /label="yfmS gene" downshifts 758983 /Source="Nicolas_upshifts" /id="D364" /incds=0 /nref=208 /ntot=237 /MaxReadThrough="2.9987" /MaxDrop="6.02377" /score="31.9989755" /energy="-16.7" /TU="U555" /idTUdmin="U555" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" promotor_-35 759067..759074 /Source="Nicolas_upshift_promotors" /id="U557" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.953046953046953" /psig=1 /xcortree=1991 /SigmaFactorBS="tatcctgcatttccatgaaattcgtctgacgtttTACTAGTT ttattccagcggcTGATTTAAAATGTACACATGaacttacgtgaggattgataggaac c" /listShort="yfmR, yfmQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 759088..759107 /Source="Nicolas_upshift_promotors" /id="U557" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.953046953046953" /psig=1 /xcortree=1991 /SigmaFactorBS="tatcctgcatttccatgaaattcgtctgacgtttTACTAGTT ttattccagcggcTGATTTAAAATGTACACATGaacttacgtgaggattgataggaac c" /listShort="yfmR, yfmQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 759093 /Source="Nicolas_upshifts" /id="U557" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.953046953046953" /psig=1 /xcortree=1991 /SigmaFactorBS="tatcctgcatttccatgaaattcgtctgacgtttTACTAGTT ttattccagcggcTGATTTAAAATGTACACATGaacttacgtgaggattgataggaac c" /listShort="yfmR, yfmQ" /GFF_Attribute="listLong" /label="upshifts" CDS 759134..761023 /gene="ettA" /locus_tag="BSU_07370" /old_locus_tag="BSU07370" /EC_number="3.6.3.-" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10715006, 16109936, 18848624, 19948254, 24389465, 24389466; Product type r : regulator" /codon_start=1 /transl_table=11 /product="putative energy-dependent translational throttleA" /protein_id="NP_388618.1" /db_xref="EnsemblGenomes-Gn:BSU07370" /db_xref="EnsemblGenomes-Tr:CAB12556" /db_xref="GOA:O06476" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR032524" /db_xref="InterPro:IPR032781" /db_xref="SubtiList:BG12969" /db_xref="UniProtKB/Swiss-Prot:O06476" /translation="MSILKAENLYKTYGDKTLFDHISFHIEENERIGLIGPNGTGKST LLKVIAGLESIEEGEITKSGSVQVEFLHQDPELPAGQTVLEHIYSGESAVMKTLREYE KALYELGKDPENEQRQKHLLAAQAKMDANNAWDANTLAKTVLSKLGVNDVTKPVNELS GGQKKRVAIAKNLIQPADLLILDEPTNHLDNETIEWLEGYLSQYPGAVMLVTHDRYFL NRVTNRIYELERGSLYTYKGNYEVFLEKRAEREAQAEQKETKRQNLLRRELAWLRRGA KARSTKQKARIDRVETLKEQTGPQSSGSLDFAIGSHRLGKQVIEAENVMIAYDGRMLV DRFNELVIPGERIGIIGPNGIGKTTLLNALAGRHTPDGGDITIGQTVRIGYYTQDHSE MNGELKVIDYIKETAEVVKTADGDMITAEQMLERFLFPRSMQQTYIRKLSGGEKRRLY LLQVLMQEPNVLFLDEPTNDLDTETLSVLEDYIDQFPGVVITVSHDRYFLDRVVDRLI VFEGNGVISRFQGSYSDYMEESKAKKAAPKPAAEEKTAEAEPKKKRKKLSYKDQLEWD GIEDKIAQLEEKHEQLEADIAAAGSDFGKIQELMAEQAKTAEELEAAMDRWTELSLMI EELES*" /label="ettA CDS" gene 759134..761023 /gene="ettA" /locus_tag="BSU_07370" /old_locus_tag="BSU07370" /label="ettA gene" downshifts 761007 /Source="Nicolas_upshifts" /id="D365" /incds=0 /nref=2 /ntot=134 /MaxReadThrough="2.98669" /MaxDrop="2.72484" /score="30.3267801" /energy="-13.8" /TU="U557" /idTUdmin="U557" /TUdmin="-572" /isTUend="FALSE" /label="downshifts" misc_feature 761087..761106 /Source="Nicolas_upshift_promotors" /id="U558" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5004995004995" /psig="0.99000999000999" /xcortree=1625 /SigmaFactorBS="gcagcaggccgcgctttttttcacataatggacaaaaacgaa ccggcctgctTATGTTAGGATAAAGTTGTGtgtcagcggcacatggaaaactaacgga g" /listShort="yfmQ" /listLong="yfmP, yfmO" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 761095 /Source="Nicolas_upshifts" /id="U558" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5004995004995" /psig="0.99000999000999" /xcortree=1625 /SigmaFactorBS="gcagcaggccgcgctttttttcacataatggacaaaaacgaa ccggcctgctTATGTTAGGATAAAGTTGTGtgtcagcggcacatggaaaactaacgga g" /listShort="yfmQ" /listLong="yfmP, yfmO" /label="upshifts" CDS 761146..761592 /gene="yfmQ" /locus_tag="BSU_07380" /old_locus_tag="BSU07380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 26483775" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388619.1" /db_xref="EnsemblGenomes-Gn:BSU07380" /db_xref="EnsemblGenomes-Tr:CAB12557" /db_xref="GOA:O06475" /db_xref="InterPro:IPR019723" /db_xref="SubtiList:BG12968" /db_xref="UniProtKB/Swiss-Prot:O06475" /translation="MTWAIVMLILMSLVKIVLTCLPTGVIEWLLGKFEVHAKLSDENA SLSLDGKRLEGAEKQKVIDQFNEAIFLEKYYIYPGDEERYLHPENGGTPLVIDTKKGK KDVKLFVYRYDDHIDVVKQYKKKVIAYRVLSESLQKESLSVAGSLA*" /label="yfmQ CDS" gene 761146..761592 /gene="yfmQ" /locus_tag="BSU_07380" /old_locus_tag="BSU07380" /label="yfmQ gene" downshifts complement(761148) /Source="Nicolas_upshifts" /id="D366" /incds=0 /nref=48 /ntot=154 /MaxReadThrough="1.16717" /MaxDrop="4.57866" /score="0.689181271" /energy="-10.2" /TU="NA" /idTUdmin="U559" /TUdmin=1 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(761232..761235) /Source="Nicolas_upshift_promotors" /id="U559" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.597402597402597" /psig="0.063936063936064" /xcortree=1597 /SigmaFactorBS="tttccatctagagagagactcgcattttcgtcactcagcttg gCGtgcacttcaaatttgccGAGCagccattctatgacgcctgtaggaagacaggtta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(761237) /Source="Nicolas_upshifts" /id="U559" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.597402597402597" /psig="0.063936063936064" /xcortree=1597 /SigmaFactorBS="tttccatctagagagagactcgcattttcgtcactcagcttg gCGtgcacttcaaatttgccGAGCagccattctatgacgcctgtaggaagacaggtta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(761253..761254) /Source="Nicolas_upshift_promotors" /id="U559" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.597402597402597" /psig="0.063936063936064" /xcortree=1597 /SigmaFactorBS="tttccatctagagagagactcgcattttcgtcactcagcttg gCGtgcacttcaaatttgccGAGCagccattctatgacgcctgtaggaagacaggtta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 761579 /Source="Nicolas_upshifts" /id="D367" /incds=0 /nref=254 /ntot=267 /MaxReadThrough="3.12706" /MaxDrop="7.87026" /score="13.6774886" /energy="-8" /TU="U558" /idTUdmin="U557" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 761655..761662 /Source="Nicolas_upshift_promotors" /id="U560" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.606393606393606" /psig="0.999000999001" /xcortree=2124 /SigmaFactorBS="gtcttttttattgttttttaaaacttaACGTTTACgttaagg ttcaaaAGGTGTATAATGGTAACAGAaacggcgaagggggatttaccttggaatggat g" /listShort="yfmP, yfmO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 761676..761695 /Source="Nicolas_upshift_promotors" /id="U560" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.606393606393606" /psig="0.999000999001" /xcortree=2124 /SigmaFactorBS="gtcttttttattgttttttaaaacttaACGTTTACgttaagg ttcaaaAGGTGTATAATGGTAACAGAaacggcgaagggggatttaccttggaatggat g" /listShort="yfmP, yfmO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 761688 /Source="Nicolas_upshifts" /id="U560" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.606393606393606" /psig="0.999000999001" /xcortree=2124 /SigmaFactorBS="gtcttttttattgttttttaaaacttaACGTTTACgttaagg ttcaaaAGGTGTATAATGGTAACAGAaacggcgaagggggatttaccttggaatggat g" /listShort="yfmP, yfmO" /GFF_Attribute="listLong" /label="upshifts" CDS 761717..762139 /gene="copP" /locus_tag="BSU_07390" /old_locus_tag="BSU07390" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14663075" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14663075; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (MerR family) of metal(copper) efflux transporter expression" /protein_id="NP_388620.1" /db_xref="EnsemblGenomes-Gn:BSU07390" /db_xref="EnsemblGenomes-Tr:CAB12558" /db_xref="GOA:O06474" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="SubtiList:BG12967" /db_xref="UniProtKB/Swiss-Prot:O06474" /translation="MEWMKIDQVAKRSGLTKRTIRFYEEIGLIPAPKRTDGGVRLYSE DDMEELEKVISTKEVLGFSLQELQHFMETSRQLELNKEGYLLSLDPKERKEKLEEIQE TLNHQLDLIDEKIRTFQSFKERLQGMKGKAERAIQSIE*" /label="copP CDS" gene 761717..762139 /gene="copP" /locus_tag="BSU_07390" /old_locus_tag="BSU07390" /label="copP gene" downshifts 761975 /Source="Nicolas_upshifts" /id="D368" /incds=1 /nref=2 /ntot=135 /MaxReadThrough="4.24358" /MaxDrop="2.69696" /score="13.6774886" /energy="-8" /TU="U560" /idTUdmin="U558" /TUdmin=308 /isTUend="FALSE" /label="downshifts" CDS 762205..763395 /gene="copO" /locus_tag="BSU_07400" /old_locus_tag="BSU07400" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:14663075, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14663075, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="metal (copper) efflux transporter" /protein_id="NP_388621.1" /db_xref="EnsemblGenomes-Gn:BSU07400" /db_xref="EnsemblGenomes-Tr:CAB12559" /db_xref="GOA:O06473" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12966" /db_xref="UniProtKB/Swiss-Prot:O06473" /translation="MDKTTQVNQKTGLLSQPKAVWAVAFACVISFMGIGLVDPILPAI AAQLHASPSEVSLLFTSYLLVTGFMMFFSGAISSRIGAKWTLILGLIFIIVFAGLGGS SSSIAQLVGYRGGWGLGNALFISTALAVIVGVSVGGSAQAIILYEAALGLGISVGPLA GGELGSISWRAPFFGVSVLMFIALIAISFMLPKLPKPAKRVGVFDAMKALKYKGLLTM AVSAFLYNFGFFILLAYSPFVLDLDEHGLGYVFFGWGLLLAITSVFTAPLVHKALGTV RSLVVLFIAFAAILVIMGIWTDHQTLIITCIVVAGAVLGMVNTIMTTAVMGSAPVERS IASSAYSSVRFIGGALAPWIAGMLSEHFTASTPYTVGGIVVFVGMLVLLMGRKHLAGI KAGH*" /label="copO CDS" gene 762205..763395 /gene="copO" /locus_tag="BSU_07400" /old_locus_tag="BSU07400" /label="copO gene" downshifts complement(763459) /Source="Nicolas_upshifts" /id="D369" /incds=0 /nref=1 /ntot=10 /MaxReadThrough="-0.0437700000000003" /MaxDrop="2.92105" /score="-8.93016606" /energy="-11.6" /TU="NA" /idTUdmin="U562" /TUdmin=528 /isTUend="FALSE" /label="downshifts" CDS 763686..763841 /gene="yfmN" /locus_tag="BSU_07410" /old_locus_tag="BSU07410" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_388622.1" /db_xref="EnsemblGenomes-Gn:BSU07410" /db_xref="EnsemblGenomes-Tr:CAB12560" /db_xref="SubtiList:BG12965" /db_xref="UniProtKB/Swiss-Prot:O06472" /translation="MDKAKPDEYDQKCLETLYQYIHSVMKNSFSRSSGLPLGKMRRIL SCLPKES*" /label="yfmN CDS" gene 763686..763841 /gene="yfmN" /locus_tag="BSU_07410" /old_locus_tag="BSU07410" /label="yfmN gene" CDS complement(763961..765517) /gene="ettM" /locus_tag="BSU_07420" /old_locus_tag="BSU07420" /EC_number="3.6.3.-" /function="16.7: Manage energy" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12486040, 16109936, 16684363, 22333191, 24389466; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative energy-sensing inhibitor of translation" /protein_id="NP_388623.2" /db_xref="EnsemblGenomes-Gn:BSU07420" /db_xref="EnsemblGenomes-Tr:CAB12571" /db_xref="GOA:O34512" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR032781" /db_xref="SubtiList:BG12964" /db_xref="UniProtKB/Swiss-Prot:O34512" /translation="MSILSVKDLSHGFGDRAIFNNVSFRLLKGEHVGLIGANGEGKST FMNIITGKLEPDEGKVEWSKNVRVGYLDQHTVLEKGKSIRDVLKDAFHYLFAMEEEMN EIYNKMGEADPDELEKLLEEVGVIQDALTNNDFYVIDSKVEEIARGLGLSDIGLERDV TDLSGGQRTKVLLAKLLLEKPEILLLDEPTNYLDEQHIEWLKRYLQEYENAFILISHD IPFLNSVINLIYHVENQELTRYVGDYHQFMEVYEVKKQQLEAAYKKQQQEVAELKDFV ARNKARVSTRNMAMSRQKKLDKMDMIELAAEKPKPEFHFKPARTSGKLIFETKDLVIG YDSPLSRPLNLRMERGQKIALYGANGIGKTTLLKSLLGEIQPLEGSVERGEHIYTGYF EQEVKETNNNTCIEEVWSEFPSYTQYEIRAALAKCGLTTKHIESRVSVLSGGEKAKVR LCKLINSETNLLVLDEPTNHLDADAKEELKRALKEYKGSILLISHEPDFYMDIATETW NCESWTTKVL*" /label="ettM CDS" gene complement(763961..765517) /gene="ettM" /locus_tag="BSU_07420" /old_locus_tag="BSU07420" /label="ettM gene" downshifts complement(763985) /Source="Nicolas_upshifts" /id="D370" /incds=0 /nref=173 /ntot=264 /MaxReadThrough="0.35675" /MaxDrop="5.82627" /score="21.7805812" /energy="-12" /TU="NA" /idTUdmin="U562" /TUdmin=2 /isTUend="TRUE" /label="downshifts" promotor_-35 765347..765353 /Source="Nicolas_upshift_promotors" /id="U561" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=894 /SigmaFactorBS="tttttgaccattcgacttttccCTCATCAggttcaagctttc cGGTAATAATATTcatgaaggttgattttccttcaccgtttgcgccgatcaagccgac g" /listShort="yfmL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 765368..765379 /Source="Nicolas_upshift_promotors" /id="U561" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=894 /SigmaFactorBS="tttttgaccattcgacttttccCTCATCAggttcaagctttc cGGTAATAATATTcatgaaggttgattttccttcaccgtttgcgccgatcaagccgac g" /listShort="yfmL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 765385 /Source="Nicolas_upshifts" /id="U561" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=894 /SigmaFactorBS="tttttgaccattcgacttttccCTCATCAggttcaagctttc cGGTAATAATATTcatgaaggttgattttccttcaccgtttgcgccgatcaagccgac g" /listShort="yfmL" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(765567..765586) /Source="Nicolas_upshift_promotors" /id="U562" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.854145854145854" /psig="0.927072927072927" /xcortree=2609 /SigmaFactorBS="gcaatttttctttttctttcctataCCTTTcaacattccgaa tccTCCTTTATAATCAAAAGGGTgaatattacacgccgattgtgcgtgtttgataacg a" /listShort="yfmM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(765571) /Source="Nicolas_upshifts" /id="U562" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.854145854145854" /psig="0.927072927072927" /xcortree=2609 /SigmaFactorBS="gcaatttttctttttctttcctataCCTTTcaacattccgaa tccTCCTTTATAATCAAAAGGGTgaatattacacgccgattgtgcgtgtttgataacg a" /listShort="yfmM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(765602..765606) /Source="Nicolas_upshift_promotors" /id="U562" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.854145854145854" /psig="0.927072927072927" /xcortree=2609 /SigmaFactorBS="gcaatttttctttttctttcctataCCTTTcaacattccgaa tccTCCTTTATAATCAAAAGGGTgaatattacacgccgattgtgcgtgtttgataacg a" /listShort="yfmM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 765627..765630 /Source="Nicolas_upshift_promotors" /id="U563" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=2547 /SigmaFactorBS="attcggaatgttgaaaggtataggaaagaaaaagaaaaATTG cgttccgggcgaggtTTTGAGATACTATGGAATAGatttcaggaattgaggagaacaa a" /listShort="yfmL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 765646..765665 /Source="Nicolas_upshift_promotors" /id="U563" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=2547 /SigmaFactorBS="attcggaatgttgaaaggtataggaaagaaaaagaaaaATTG cgttccgggcgaggtTTTGAGATACTATGGAATAGatttcaggaattgaggagaacaa a" /listShort="yfmL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 765649 /Source="Nicolas_upshifts" /id="U563" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=2547 /SigmaFactorBS="attcggaatgttgaaaggtataggaaagaaaaagaaaaATTG cgttccgggcgaggtTTTGAGATACTATGGAATAGatttcaggaattgaggagaacaa a" /listShort="yfmL" /GFF_Attribute="listLong" /label="upshifts" CDS 765690..766820 /gene="yfmL" /locus_tag="BSU_07430" /old_locus_tag="BSU07430" /EC_number="3.6.1.-" /function="16.6: Maintain" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11976317; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ATP-dependent RNA helicase" /protein_id="NP_388624.1" /db_xref="EnsemblGenomes-Gn:BSU07430" /db_xref="EnsemblGenomes-Tr:CAB12572" /db_xref="GOA:O34750" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12963" /db_xref="UniProtKB/Swiss-Prot:O34750" /translation="MTQTWPFLHNAQSFIQENWNASGFQKPTPVQEQAAQLIMDGKDV IAESPTGTGKTLAYALPVLERIKPEQKHPQAVILAPSRELVMQIFQVIQDWKAGSELR AASLIGGANVKKQVEKLKKHPHIIVGTPGRVFELIKAKKLKMHEVKTIVLDETDQLVL PEHRETMKQIIKTTLRDRQLLCFSATLKKETEDVLRELAQEPEVLKVQRSKAEAGKVK HQYLICDQRDKVKLLQKLSRLEGMQALVFVRDIGNLSVYAEKLAYHHVELGVLHSEAK KMERAKIIATFEDGEFPLLLATDIAARGLDIENLPYVIHADIPDEDGYVHRSGRTGRA GKEGNVLSLVTKLEESKLKKMAKKLGVELSEAVYAGGKLKTK*" /label="yfmL CDS" gene 765690..766820 /gene="yfmL" /locus_tag="BSU_07430" /old_locus_tag="BSU07430" /label="yfmL gene" downshifts 766803 /Source="Nicolas_upshifts" /id="D371" /incds=0 /nref=43 /ntot=133 /MaxReadThrough="2.93747" /MaxDrop="4.41385" /score="23.4253604" /energy="-5.9" /TU="NA" /idTUdmin="U563" /TUdmin="-12" /isTUend="TRUE" /label="downshifts" CDS 766888..767334 /gene="yfmK" /locus_tag="BSU_07440" /old_locus_tag="BSU07440" /EC_number="2.3.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_388625.1" /db_xref="EnsemblGenomes-Gn:BSU07440" /db_xref="EnsemblGenomes-Tr:CAB12573" /db_xref="GOA:O34536" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG12962" /db_xref="UniProtKB/Swiss-Prot:O34536" /translation="MASIDRFQVMQEPELKILEHWFENEDTRRRMDGMLLLDEWYARV NKDKHDTVIMAYDGQLPAGMVVIEFGEERTYIGLIVNPLYRLKGYGKQILQKLMTEPD FTSVREWVACIEEDNRISLACFQAAGFTLEDTEPDEDGFLTLILRN*" /label="yfmK CDS" gene 766888..767334 /gene="yfmK" /locus_tag="BSU_07440" /old_locus_tag="BSU07440" /label="yfmK gene" CDS complement(767387..768406) /gene="yfmJ" /locus_tag="BSU_07450" /old_locus_tag="BSU07450" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388626.1" /db_xref="EnsemblGenomes-Gn:BSU07450" /db_xref="EnsemblGenomes-Tr:CAB12574" /db_xref="GOA:O34812" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR020843" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12961" /db_xref="UniProtKB/Swiss-Prot:O34812" /translation="MTASQQQIQLARRPQGIPVHEDFRFETIPVPEPKQGEVLVKTLY VSVDPYMRGRMQDTKSYVEPFALDKALSGGVIAEVVSDGNHLKKGDIVIGNLSWQEFS AVSESALRKIDTSLAPASAYLGILGMTGLTAYFGLLDIGRPKEGETVVVSGAAGAVGS TVGQIAKIKGARVVGIAGSDEKIDYLKQELQFDEAINYKTADDIQKALQNACPDGVDV YFDNVGGPISDAVMNLLNEFARIPVCGAISSYNAESEADDMGPRVQSKLIKTKSLMQG FIVSDYSDRFSEGAKQLAEWLKAGKLHYEETITEGFENIPDAFLGLFKGENKGKQLIK VSDPS*" /label="yfmJ CDS" gene complement(767387..768406) /gene="yfmJ" /locus_tag="BSU_07450" /old_locus_tag="BSU07450" /label="yfmJ gene" downshifts complement(767397) /Source="Nicolas_upshifts" /id="D372" /incds=0 /nref=183 /ntot=252 /MaxReadThrough="2.26899" /MaxDrop="5.73395" /score="20.8047206" /energy="-12.8" /TU="NA" /idTUdmin="U564" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(768427..768446) /Source="Nicolas_upshift_promotors" /id="U564" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.654345654345654" /psig=1 /xcortree=3180 /SigmaFactorBS="accttttttgtatgccagcttacctTTTGTATTtcctctcct gtcCATGTTACAGTGGTGTCAACcaagtgataggaggatgaaaatgacagcatctcag c" /listShort="yfmJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(768431) /Source="Nicolas_upshifts" /id="U564" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.654345654345654" /psig=1 /xcortree=3180 /SigmaFactorBS="accttttttgtatgccagcttacctTTTGTATTtcctctcct gtcCATGTTACAGTGGTGTCAACcaagtgataggaggatgaaaatgacagcatctcag c" /listShort="yfmJ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(768433..768887) /Source="Nicolas_S_feature" /locus_tag="new_818856_819310_c" /HighExp="S2, S1, Pyr, T4.0H, T0.0H, T-2.40H, T3.30H, T-1.40H, T-0.40H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S252" promotor_-35 complement(768459..768466) /Source="Nicolas_upshift_promotors" /id="U564" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.654345654345654" /psig=1 /xcortree=3180 /SigmaFactorBS="accttttttgtatgccagcttacctTTTGTATTtcctctcct gtcCATGTTACAGTGGTGTCAACcaagtgataggaggatgaaaatgacagcatctcag c" /listShort="yfmJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 768525..768532 /Source="Nicolas_upshift_promotors" /id="U565" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.993006993006993" /psig="0.999000999001" /xcortree=1939 /SigmaFactorBS="atagatgagcttatgctttctacaagctctttTGTTTTAAaa gttctctttagTCATTTATCATTATTAGAAAacagaacagaaaaagagctcctgtaca c" /listShort="S253" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 768546..768565 /Source="Nicolas_upshift_promotors" /id="U565" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.993006993006993" /psig="0.999000999001" /xcortree=1939 /SigmaFactorBS="atagatgagcttatgctttctacaagctctttTGTTTTAAaa gttctctttagTCATTTATCATTATTAGAAAacagaacagaaaaagagctcctgtaca c" /listShort="S253" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 768553..769650 /Source="Nicolas_S_feature" /locus_tag="new_818976_820073" /HighExp="Etha, dia5, Diami, C30, dia15, T5.0H, S8, T3.0H, M0t90, LPhT" /AntisenseName="yfmI" /AntisenseCor="0.135213889213362" /AntisenseRegPval="-1.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S253" upshifts 768553 /Source="Nicolas_upshifts" /id="U565" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.993006993006993" /psig="0.999000999001" /xcortree=1939 /SigmaFactorBS="atagatgagcttatgctttctacaagctctttTGTTTTAAaa gttctctttagTCATTTATCATTATTAGAAAacagaacagaaaaagagctcctgtaca c" /listShort="S253" /GFF_Attribute="listLong" /label="upshifts" CDS complement(768888..770108) /gene="yfmI" /locus_tag="BSU_07460" /old_locus_tag="BSU07460" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388627.1" /db_xref="EnsemblGenomes-Gn:BSU07460" /db_xref="EnsemblGenomes-Tr:CAB12575" /db_xref="GOA:O34440" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12960" /db_xref="UniProtKB/Swiss-Prot:O34440" /translation="MSKGYYSILFSQTTTNLGFSLYTMVVISFLFKMTNSTTIASMVT LISIIFRIFGSAILPLITIRLKLPLTIIISQLIQMLLLICLFYALLRTYSNQTLILVF IIISCISFFNGWFSPLKSAIIGEIISPDRRVKANGLLSTVDQTFQFVGWSLGGLIIAF LGEGYTIILTIFLLFTSLLSLLFCLPHGHANSVIREKNSPNKSIVSGWRYLFSQKKLR TIIIMDLIESWAGMIWIGSVSLAFVNEVLHKGESWWGFINGAYYLGSMIGGFIIYKLS ERFQNKLINFMLIGAVSYGSLTLIYGFISNSYLALILVLFMGPAYILRDLTQETLIQN ITTEQTRINIMSARSSLVQFIFMFSILAIGAISDFLGVRLVYVSAGILLLVSAIYGFS QLQFKKKVNKHISF*" /label="yfmI CDS" gene complement(768888..770108) /gene="yfmI" /locus_tag="BSU_07460" /old_locus_tag="BSU07460" /label="yfmI gene" promotor_-10 complement(770145..770164) /Source="Nicolas_upshift_promotors" /id="U566" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.899100899100899" /psig="0.996003996003996" /xcortree=2925 /SigmaFactorBS="gtaaatagtttacaaggaaatttttTCTTTACTtttgttgtt ttaaggTGTTTAAATATGTTTAAGCTctttaccgagaaaaattattccaagggaggat a" /listShort="yfmI, S252, yfmJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(770152) /Source="Nicolas_upshifts" /id="U566" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.899100899100899" /psig="0.996003996003996" /xcortree=2925 /SigmaFactorBS="gtaaatagtttacaaggaaatttttTCTTTACTtttgttgtt ttaaggTGTTTAAATATGTTTAAGCTctttaccgagaaaaattattccaagggaggat a" /listShort="yfmI, S252, yfmJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(770180..770187) /Source="Nicolas_upshift_promotors" /id="U566" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.899100899100899" /psig="0.996003996003996" /xcortree=2925 /SigmaFactorBS="gtaaatagtttacaaggaaatttttTCTTTACTtttgttgtt ttaaggTGTTTAAATATGTTTAAGCTctttaccgagaaaaattattccaagggaggat a" /listShort="yfmI, S252, yfmJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 770206..770213 /Source="Nicolas_upshift_promotors" /id="U567" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=480 /SigmaFactorBS="ccttaaaacaacaaaagtaaagaaaaaatttccttgtaaacT ATTTACTtttattctatttatTGTTATTGTTTATTTAAGTTctctgactattctatca a" /listShort="S254, yfmG, S256, S257, S258, S259, yfmA, yflT" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 770225..770400 /Source="Nicolas_S_feature" /locus_tag="new_820648_820823" /HighExp="LoTm, T-1.10H, T-0.40H, S3, M9-stat, T0.0H, T-1.40H, BC, T2.0H, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.98260400000000003" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S254" upshifts 770225 /Source="Nicolas_upshifts" /id="U567" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=480 /SigmaFactorBS="ccttaaaacaacaaaagtaaagaaaaaatttccttgtaaacT ATTTACTtttattctatttatTGTTATTGTTTATTTAAGTTctctgactattctatca a" /listShort="S254, yfmG, S256, S257, S258, S259, yfmA, yflT" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 770228..770247 /Source="Nicolas_upshift_promotors" /id="U567" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=480 /SigmaFactorBS="ccttaaaacaacaaaagtaaagaaaaaatttccttgtaaacT ATTTACTtttattctatttatTGTTATTGTTTATTTAAGTTctctgactattctatca a" /listShort="S254, yfmG, S256, S257, S258, S259, yfmA, yflT" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 770357 /Source="Nicolas_upshifts" /id="D373" /incds=0 /nref=34 /ntot=117 /MaxReadThrough="8.67835" /MaxDrop="8.45742" /score="4.02328636" /energy="-13.7" /TU="U567" /idTUdmin="U565" /TUdmin=748 /isTUend="FALSE" /label="downshifts" CDS 770444..771907 /gene="yfmG" /locus_tag="BSU_07480" /old_locus_tag="BSU07480" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_388629.1" /db_xref="EnsemblGenomes-Gn:BSU07480" /db_xref="EnsemblGenomes-Tr:CAB12577" /db_xref="InterPro:IPR005532" /db_xref="InterPro:IPR016187" /db_xref="SubtiList:BG12958" /db_xref="UniProtKB/Swiss-Prot:O34722" /translation="MTLLMQDHKSIYNKDIEILIEVEELITSVPENKKNDFKSLIDNR IMTLLNKIQHPVAAENVFGMCIAYPNTYIRYRLIDFVEKWVPYFSAVETIINLTQDPD DLVSFKAMDVCANHKIEESVAYLSSIIDDVRESISYPKKPVGLGAQKVLSTLLDIFGV EKHEELVMLKNYFDQNGILPNNFDFEEKIPQSLIEEFEKTEEDGMILIPGGFFEFGLN ENEIPDKTFNWKDAVPRQKVWLPPFFIDKYPVTNKDYDIFTEFIEENGHIFCHPNEPQ NKQHRRNTYWDDRYLDNHPVTGIDFYDAFAYARYKGKELPTEFQWEKAARGEKGNVWP WGDKFDPAKVQYAGSLYNEPITSLKSWRENLLKAHADKELNHLTSDIFEQNGESPYGV CGMIGGTWEWTRSELKTKRAFHPIFENVPFNSVNSFAVLKGGSFFSHPGLMFPSFRAK DIPFCRHNEMGIRCVKNIPVYKIRESINGPITNKAIY*" /label="yfmG CDS" gene 770444..771907 /gene="yfmG" /locus_tag="BSU_07480" /old_locus_tag="BSU07480" /label="yfmG gene" S_feature complement(770809..772479) /Source="Nicolas_S_feature" /locus_tag="new_821232_822902_c" /HighExp="H2O2, C30, Salt, Lbstat, dia15, LPhT, dia5, Paraq, HiOs, Diami" /AntisenseName="yfmG" /AntisenseCor="-0.58045119682782798" /AntisenseRegPval="-24.9" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 1" /TUlongSig="SigA" /TUlongPSig="0.996" /label="S255" S_feature 771908..772401 /Source="Nicolas_S_feature" /locus_tag="new_822331_822824" /HighExp="LoTm, T0.0H, T-1.40H, T-0.40H, T-2.40H, T-1.10H, Pyr, T-3.40H, SMMPr, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S256" promotor_-35 772389..772394 /Source="Nicolas_upshift_promotors" /id="U568" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=758 /SigmaFactorBS="aaaagagtatctcgtatagaacataagaagaatgacgagttt tttaAGATTAtcatcaattatgtgaGAATAAAATATTATAAGGGaaaatgaaggctgt c" /listShort="S257" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 772403..775668 /Source="Nicolas_S_feature" /locus_tag="new_822826_826091" /HighExp="LoTm, Pyr, B36, T3.30H, T2.0H, T-0.40H, T2.30H, B60, T4.0H, T3.0H" /AntisenseName="yfmE" /AntisenseCor="-0.61640022790163695" /AntisenseRegPval="-28.8" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="0.982, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S257" upshifts 772403 /Source="Nicolas_upshifts" /id="U568" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=758 /SigmaFactorBS="aaaagagtatctcgtatagaacataagaagaatgacgagttt tttaAGATTAtcatcaattatgtgaGAATAAAATATTATAAGGGaaaatgaaggctgt c" /listShort="S257" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 772410..772428 /Source="Nicolas_upshift_promotors" /id="U568" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=758 /SigmaFactorBS="aaaagagtatctcgtatagaacataagaagaatgacgagttt tttaAGATTAtcatcaattatgtgaGAATAAAATATTATAAGGGaaaatgaaggctgt c" /listShort="S257" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(772480..773280) /gene="fecF" /locus_tag="BSU_07490" /old_locus_tag="BSU07490" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16672620, 22194458" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16672620, 22194458; Product type t: transporter" /codon_start=1 /transl_table=11 /product="iron-dicitrate ABC transporter (ATP-binding protein)" /protein_id="NP_388630.1" /db_xref="EnsemblGenomes-Gn:BSU07490" /db_xref="EnsemblGenomes-Tr:CAB12578" /db_xref="GOA:O34510" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12957" /db_xref="UniProtKB/Swiss-Prot:O34510" /translation="MGKLAADQLTLSYDSTVIIDGVDLKIEEGKITALIGANGCGKST ILKSLARLMAPKSGTVLLEGKDIHRQPSKEVAKKLAILPQSPQAPEGLTVEELCYFGR HPHKKLLSKHTQEDHDMVEWALEATGMIELKDRTLDALSGGQRQRAWISMALAQGTDL LLLDEPTTYLDISHQIEVLELLKKLNRDHGRTVVMVLHDLNQAAQYADYLISVLDGKI YNAGTPEDVFTQPFFREVFGLECCIMRSPIDQKPMCLPTGLCPKLRAK*" /label="fecF CDS" gene complement(772480..773280) /gene="fecF" /locus_tag="BSU_07490" /old_locus_tag="BSU07490" /label="fecF gene" CDS complement(773293..774294) /gene="fecE" /locus_tag="BSU_07500" /old_locus_tag="BSU07500" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16672620, 16850406, 22194458" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16672620, 16850406, 22194458; Product type t: transporter" /codon_start=1 /transl_table=11 /product="iron-dicitrate ABC transporter (permease)" /protein_id="NP_388631.1" /db_xref="EnsemblGenomes-Gn:BSU07500" /db_xref="EnsemblGenomes-Tr:CAB12579" /db_xref="GOA:O34832" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG12956" /db_xref="UniProtKB/Swiss-Prot:O34832" /translation="MKKTTRKQKRPLLAILILAVILIVLSVISIGIGALYISPDAVVT NLLGLDHSFEFIIQQYRLPRIILAILAGAGLAAAGAILQGVIRNPLASPDVVGISKGS GLAAMAVILIFPESPVYVLPFSAFAGAAIIAVLLLMIARKKSIQPSSLALSGIALGAV CHAGMQYMMVKFPGDVNAALIWLTGSLWGRNWEEVKLLAPWLLILFPIVCILIPKLDL MSLGDELAQGLGENANRLRFILIFTAVALAGSCVAVVGSIGFIGLLAPHIARRLTGEK AKYLLPASALIGAIILLIADTLGRGIMPPVEIPAGILTAVIGAPYFLYLLKFEARKQ* " /label="fecE CDS" gene complement(773293..774294) /gene="fecE" /locus_tag="BSU_07500" /old_locus_tag="BSU07500" /label="fecE gene" promotor_-10 complement(773880..773899) /Source="Nicolas_upshift_promotors" /id="U569" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.954045954045954" /psig="0.998001998001998" /xcortree=2068 /SigmaFactorBS="gagtcgccggtatacgtgcttccgttctccgCATTTGCCgga gccgccattatTGCTGTACTATTATTAATGAtagcccgaaaaaagagcattcagccct c" /listShort="yfmF, S255" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(773892) /Source="Nicolas_upshifts" /id="U569" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.954045954045954" /psig="0.998001998001998" /xcortree=2068 /SigmaFactorBS="gagtcgccggtatacgtgcttccgttctccgCATTTGCCgga gccgccattatTGCTGTACTATTATTAATGAtagcccgaaaaaagagcattcagccct c" /listShort="yfmF, S255" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(773914..773921) /Source="Nicolas_upshift_promotors" /id="U569" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.954045954045954" /psig="0.998001998001998" /xcortree=2068 /SigmaFactorBS="gagtcgccggtatacgtgcttccgttctccgCATTTGCCgga gccgccattatTGCTGTACTATTATTAATGAtagcccgaaaaaagagcattcagccct c" /listShort="yfmF, S255" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(774291..775292) /gene="fecD" /locus_tag="BSU_07510" /old_locus_tag="BSU07510" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 15849754, 16672620, 16850406, 22194458" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15849754, 16672620, 16850406, 22194458; Product type t : transporter" /codon_start=1 /transl_table=11 /product="iron-dicitrate ABC transporter (permease)" /protein_id="NP_388632.1" /db_xref="EnsemblGenomes-Gn:BSU07510" /db_xref="EnsemblGenomes-Tr:CAB12580" /db_xref="GOA:O34933" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG12955" /db_xref="UniProtKB/Swiss-Prot:O34933" /translation="MYHSAKRRSSSRLMMFIIALIIFIFGLGLNLSVGASDISIIDSL KYLFVWDGSKEQLIISTLRLPRTLIGVFVGASLAVAGALMQAMTRNPLASPQIFGVNA GASLFVVASLVILPASPYSSVIFAFAGAAAGGAIVYMIASSGGMTPVKLALSGMAVHL FLSSMTQAIIILNESGEDVLYWMTGAIDGSNWQDVITIAPFSVIGIGLALVFSGSVSV LGLGDETAKGLGQNMNGIRILISLIILILSGASVAVAGPIGFVGLLVPHIVRKLIGEH YQYVLPFSALFGAILLVYADVLARWIAFPYESPVGIVTAIIGTPFFLYLARKGRNLK* " /label="fecD CDS" gene complement(774291..775292) /gene="fecD" /locus_tag="BSU_07510" /old_locus_tag="BSU07510" /label="fecD gene" misc_feature complement(775362..775381) /Source="Nicolas_upshift_promotors" /id="U570" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.664335664335664" /psig="0.701298701298701" /xcortree=1492 /SigmaFactorBS="acacttggacaagattcagaggcatcaagtctagtgaaacaa gcgccaaagatgtgcttaaaAAAGTGTATAATAAATAGGAcaaatgagaagcgagggg a" /listShort="yfmD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(775364..776311) /gene="fecC" /locus_tag="BSU_07520" /old_locus_tag="BSU07520" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 15849754, 16672620, 16850406, 22194458" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15849754, 16672620, 16850406, 22194458; Product type t : transporter" /codon_start=1 /transl_table=11 /product="iron-dicitrate ABC transporter (binding lipoprotein)" /protein_id="NP_388633.1" /db_xref="EnsemblGenomes-Gn:BSU07520" /db_xref="EnsemblGenomes-Tr:CAB12581" /db_xref="GOA:O34348" /db_xref="InterPro:IPR002491" /db_xref="SubtiList:BG12954" /db_xref="UniProtKB/Swiss-Prot:O34348" /translation="MRTYSNKLIAIMSVLLLACLIVSGCSSSQNNNGSGKSESKDSRV IHDEEGKTTVSGTPKRVVVLELSFLDAVHNLGITPVGIADDNKKDMIKKLVGSSIDYT SVGTRSEPNLEVISSLKPDLIIADAERHKNIYKQLKKIAPTIELKSREATYDETIDSF TTIAKALNKEDEGKEKLAEHKKVINDLKAELPKDENRNIVLGVARADSFQLHTSSSYD GEIFKMLGFTHAVKSDNAYQEVSLEQLSKIDPDILFISANEGKTIVDEWKTNPLWKNL KAVKNGQVYDADRDTWTRFRGIKSSETSAKDVLKKVYNK*" /label="fecC CDS" gene complement(775364..776311) /gene="fecC" /locus_tag="BSU_07520" /old_locus_tag="BSU07520" /label="fecC gene" downshifts complement(775383) /Source="Nicolas_upshifts" /id="D374" /incds=0 /nref=41 /ntot=211 /MaxReadThrough="4.92983" /MaxDrop="4.53674" /score="-3.64310934" /energy="-13.9" /TU="U570,U573,U574" /idTUdmin="U570" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" upshifts complement(775383) /Source="Nicolas_upshifts" /id="U570" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.664335664335664" /psig="0.701298701298701" /xcortree=1492 /SigmaFactorBS="acacttggacaagattcagaggcatcaagtctagtgaaacaa gcgccaaagatgtgcttaaaAAAGTGTATAATAAATAGGAcaaatgagaagcgagggg a" /listShort="yfmD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 775638..775643 /Source="Nicolas_upshift_promotors" /id="U571" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1066 /SigmaFactorBS="atctgacttcacagcgtgtgtaaagcctAGCATTttaaagat ttctccgTCATAGGATGATGATGTATgaagctggaaggaatccgctcttgcaacgccg a" /listShort="S258, S259" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 775659..775677 /Source="Nicolas_upshift_promotors" /id="U571" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1066 /SigmaFactorBS="atctgacttcacagcgtgtgtaaagcctAGCATTttaaagat ttctccgTCATAGGATGATGATGTATgaagctggaaggaatccgctcttgcaacgccg a" /listShort="S258, S259" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 775670..776295 /Source="Nicolas_S_feature" /locus_tag="new_826093_826718" /HighExp="LoTm, B36, S5, S6, S4, S7, S8, S3, BT, B60" /AntisenseName="yfmC" /AntisenseCor="-0.52042999587715499" /AntisenseRegPval="-19.3" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="0.997, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S258" upshifts 775670 /Source="Nicolas_upshifts" /id="U571" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1066 /SigmaFactorBS="atctgacttcacagcgtgtgtaaagcctAGCATTttaaagat ttctccgTCATAGGATGATGATGTATgaagctggaaggaatccgctcttgcaacgccg a" /listShort="S258, S259" /GFF_Attribute="listLong" /label="upshifts" misc_feature 776291..776310 /Source="Nicolas_upshift_promotors" /id="U572" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.905094905094905" /psig="0.997002997002997" /xcortree=1855 /SigmaFactorBS="acagccggatacaatgaggcaggcgagcaataaaacactcat gatggcaatcaaCTTGTTAGAATAGGTGCGCAtgtcattcttccttttttcagattta g" /listShort="S259" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 776297..776828 /Source="Nicolas_S_feature" /locus_tag="new_826720_827251" /HighExp="LoTm, B36, S5, S4, S7, S6, S8, B60, S3, BT" /AntisenseName="yfmB" /AntisenseCor="-6.4915194654100006E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF, SigA" /TUshortPSig="0.997, 0.997, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S259" upshifts 776297 /Source="Nicolas_upshifts" /id="U572" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.905094905094905" /psig="0.997002997002997" /xcortree=1855 /SigmaFactorBS="acagccggatacaatgaggcaggcgagcaataaaacactcat gatggcaatcaaCTTGTTAGAATAGGTGCGCAtgtcattcttccttttttcagattta g" /listShort="S259" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(776353..776372) /Source="Nicolas_upshift_promotors" /id="U573" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.645354645354645" /psig=1 /xcortree=2102 /SigmaFactorBS="aaaacgcagctttctttactaaaaaaaTATTGACAtgataag ccatgcTATTATAGTGTTACATGTGAtaatgattctcattactaaatctgaaaaaagg a" /listShort="yfmC, yfmD, yfmE, yfmF, S255" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(776360) /Source="Nicolas_upshifts" /id="U573" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.645354645354645" /psig=1 /xcortree=2102 /SigmaFactorBS="aaaacgcagctttctttactaaaaaaaTATTGACAtgataag ccatgcTATTATAGTGTTACATGTGAtaatgattctcattactaaatctgaaaaaagg a" /listShort="yfmC, yfmD, yfmE, yfmF, S255" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(776386..776393) /Source="Nicolas_upshift_promotors" /id="U573" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.645354645354645" /psig=1 /xcortree=2102 /SigmaFactorBS="aaaacgcagctttctttactaaaaaaaTATTGACAtgataag ccatgcTATTATAGTGTTACATGTGAtaatgattctcattactaaatctgaaaaaagg a" /listShort="yfmC, yfmD, yfmE, yfmF, S255" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(776420..776788) /gene="yfmB" /locus_tag="BSU_07530" /old_locus_tag="BSU07530" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 25651892" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388634.1" /db_xref="EnsemblGenomes-Gn:BSU07530" /db_xref="EnsemblGenomes-Tr:CAB12582" /db_xref="InterPro:IPR021579" /db_xref="PDB:2EUC" /db_xref="SubtiList:BG12953" /db_xref="UniProtKB/Swiss-Prot:O34626" /translation="MQYFSPEQQYNAWIVSDLVKQIFHKRAGCSPGIHELAVFAEEHF HIDIDFVFSIIMNIGDIEFALTDEIEKKLSGYLSTLLPYVTADMFETSKANAHAFLSR RHGNAAYHLFVSDDAFMRKQ*" /label="yfmB CDS" gene complement(776420..776788) /gene="yfmB" /locus_tag="BSU_07530" /old_locus_tag="BSU07530" /label="yfmB gene" S_feature complement(776789..776901) /Source="Nicolas_S_feature" /locus_tag="new_827212_827324_c" /HighExp="Etha, BC, Sw, M9-stat, T3.30H, T1.30H, T3.0H, T5.0H, T2.30H, T2.0H" /AntisenseName="yfmA" /AntisenseCor="5.8024036419347599E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S260" promotor_-10 complement(776890..776909) /Source="Nicolas_upshift_promotors" /id="U574" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.967032967032967" /psig="0.996003996003996" /xcortree=128 /SigmaFactorBS="gaacattgaagagaaaaacaggaggaatggtagTAGCTATTt gttttccgtcCATGGTAAAGTGATAGGAACgggacctattttcagaaaaatcaaaatt a" /listShort="S260, yfmB, yfmC, yfmD" /listLong="yfmE, yfmF, S255" /label="promotor_-10" upshifts complement(776901) /Source="Nicolas_upshifts" /id="U574" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.967032967032967" /psig="0.996003996003996" /xcortree=128 /SigmaFactorBS="gaacattgaagagaaaaacaggaggaatggtagTAGCTATTt gttttccgtcCATGGTAAAGTGATAGGAACgggacctattttcagaaaaatcaaaatt a" /listShort="S260, yfmB, yfmC, yfmD" /listLong="yfmE, yfmF, S255" /label="upshifts" promotor_-35 complement(776921..776928) /Source="Nicolas_upshift_promotors" /id="U574" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.967032967032967" /psig="0.996003996003996" /xcortree=128 /SigmaFactorBS="gaacattgaagagaaaaacaggaggaatggtagTAGCTATTt gttttccgtcCATGGTAAAGTGATAGGAACgggacctattttcagaaaaatcaaaatt a" /listShort="S260, yfmB, yfmC, yfmD" /listLong="yfmE, yfmF, S255" /label="promotor_-35" promotor_-35 776969..776975 /Source="Nicolas_upshift_promotors" /id="U575" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=221 /SigmaFactorBS="ctaccattcctcctgtttttctcttcaatgttctggaatcTG TTTCAggtacagacgatcGGGTATGAAAGAAATATAGaaaacatgaaggaggaatatc g" /listShort="yflT, S261, pel, yflS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 776989..777007 /Source="Nicolas_upshift_promotors" /id="U575" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=221 /SigmaFactorBS="ctaccattcctcctgtttttctcttcaatgttctggaatcTG TTTCAggtacagacgatcGGGTATGAAAGAAATATAGaaaacatgaaggaggaatatc g" /listShort="yflT, S261, pel, yflS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 776989 /Source="Nicolas_upshifts" /id="U575" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=221 /SigmaFactorBS="ctaccattcctcctgtttttctcttcaatgttctggaatcTG TTTCAggtacagacgatcGGGTATGAAAGAAATATAGaaaacatgaaggaggaatatc g" /listShort="yflT, S261, pel, yflS" /GFF_Attribute="listLong" /label="upshifts" CDS 777032..777379 /gene="yflT" /locus_tag="BSU_07550" /old_locus_tag="BSU07550" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 12089032; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="heat stress induced protein" /protein_id="NP_388636.1" /db_xref="EnsemblGenomes-Gn:BSU07550" /db_xref="EnsemblGenomes-Tr:CAB12584" /db_xref="InterPro:IPR025889" /db_xref="SubtiList:BG19020" /db_xref="UniProtKB/Swiss-Prot:P80241" /translation="MKPVVKEYTNDEQLMKDVEELQKMGVAKEDVYVLAHDDDRTERL ADNTNANTIGAKETGFKHAVGNIFNKKGDELRNKIHEIGFSEDEAAQFEKRLDEGKVL LFVTDNEKVKAWA*" /label="yflT CDS" gene 777032..777379 /gene="yflT" /locus_tag="BSU_07550" /old_locus_tag="BSU07550" /label="yflT gene" downshifts complement(777033) /Source="Nicolas_upshifts" /id="D375" /incds=0 /nref=6 /ntot=28 /MaxReadThrough="1.00082" /MaxDrop="4.87687" /score="-3.31058364" /energy="-3.6" /TU="NA" /idTUdmin="U570" /TUdmin="-1848" /isTUend="FALSE" /label="downshifts" downshifts 777375 /Source="Nicolas_upshifts" /id="D376" /incds=0 /nref=56 /ntot=197 /MaxReadThrough="6.41566" /MaxDrop="7.61596" /score="-1.88723414" /energy="-5.6" /TU="U575" /idTUdmin="U567" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 777420..777500 /Source="Nicolas_S_feature" /locus_tag="new_827843_827923" /HighExp="Etha, Salt, B36, LoTm, Heat, B60, M9-stat, S8, C30, LPhT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S261" misc_feature 777501..777520 /Source="Nicolas_upshift_promotors" /id="U576" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.576423576423576" /psig="0.972027972027972" /xcortree=3242 /SigmaFactorBS="gattttgcagaatgccgcaataggatagcggaacattttcgg ttctgaatgtccctcaaTTTGCTATTATATTTTTGTGataaattggaataaaatctca c" /listShort="pel" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 777502 /Source="Nicolas_upshifts" /id="U576" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.576423576423576" /psig="0.972027972027972" /xcortree=3242 /SigmaFactorBS="gattttgcagaatgccgcaataggatagcggaacattttcgg ttctgaatgtccctcaaTTTGCTATTATATTTTTGTGataaattggaataaaatctca c" /listShort="pel" /GFF_Attribute="listLong" /label="upshifts" CDS 777570..778832 /gene="pelA" /locus_tag="BSU_07560" /old_locus_tag="BSU07560" /EC_number="4.2.2.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8262178, 12823818, 27447541" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8262178, 12823818, 27447541; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pectate lyase" /protein_id="NP_388637.1" /db_xref="EnsemblGenomes-Gn:BSU07560" /db_xref="EnsemblGenomes-Tr:CAB12585" /db_xref="GOA:P39116" /db_xref="InterPro:IPR002022" /db_xref="InterPro:IPR011050" /db_xref="InterPro:IPR012334" /db_xref="PDB:1BN8" /db_xref="PDB:2BSP" /db_xref="PDB:2NZM" /db_xref="PDB:2O04" /db_xref="PDB:2O0V" /db_xref="PDB:2O0W" /db_xref="PDB:2O17" /db_xref="PDB:2O1D" /db_xref="PDB:3KRG" /db_xref="PDB:5AMV" /db_xref="SubtiList:BG10840" /db_xref="UniProtKB/Swiss-Prot:P39116" /translation="MKKVMLATALFLGLTPAGANAADLGHQTLGSNDGWGAYSTGTTG GSKASSSNVYTVSNRNQLVSALGKETNTTPKIIYIKGTIDMNVDDNLKPLGLNDYKDP EYDLDKYLKAYDPSTWGKKEPSGTQEEARARSQKNQKARVMVDIPANTTIVGSGTNAK VVGGNFQIKSDNVIIRNIEFQDAYDYFPQWDPTDGSSGNWNSQYDNITINGGTHIWID HCTFNDGSRPDSTSPKYYGRKYQHHDGQTDASNGANYITMSYNYYHDHDKSSIFGSSD SKTSDDGKLKITLHHNRYKNIVQRAPRVRFGQVHVYNNYYEGSTSSSSYPFSYAWGIG KSSKIYAQNNVIDVPGLSAAKTISVFSGGTALYDSGTLLNGTQINASAANGLSSSVGW TPSLHGSIDASANVKSNVINQAGAGKLN*" /label="pelA CDS" gene 777570..778832 /gene="pelA" /locus_tag="BSU_07560" /old_locus_tag="BSU07560" /label="pelA gene" downshifts 778827 /Source="Nicolas_upshifts" /id="D377" /incds=0 /nref=139 /ntot=203 /MaxReadThrough="3.61256" /MaxDrop="5.92635" /score="1.82127533" /energy="-8.2" /TU="U575,U576" /idTUdmin="U576" /TUdmin="-176" /isTUend="FALSE" /label="downshifts" promotor_-35 778885..778888 /Source="Nicolas_upshift_promotors" /id="U577" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.879120879120879" /psig="0.984015984015984" /xcortree=1756 /SigmaFactorBS="gggtgctaacctttgtgttttttaattaattaaaATGTttat taacttagttAAGGAGTAGAATGGAAAAGGggatcggaaaacaagtatataggaggag a" /listShort="yflS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 778903..778922 /Source="Nicolas_upshift_promotors" /id="U577" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.879120879120879" /psig="0.984015984015984" /xcortree=1756 /SigmaFactorBS="gggtgctaacctttgtgttttttaattaattaaaATGTttat taacttagttAAGGAGTAGAATGGAAAAGGggatcggaaaacaagtatataggaggag a" /listShort="yflS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 778911 /Source="Nicolas_upshifts" /id="U577" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.879120879120879" /psig="0.984015984015984" /xcortree=1756 /SigmaFactorBS="gggtgctaacctttgtgttttttaattaattaaaATGTttat taacttagttAAGGAGTAGAATGGAAAAGGggatcggaaaacaagtatataggaggag a" /listShort="yflS" /GFF_Attribute="listLong" /label="upshifts" CDS 778959..780395 /gene="maeS" /locus_tag="BSU_07570" /old_locus_tag="BSU07570" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12949159, 15849754, 16850406, 25651892, 28436820" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12949159, 15849754, 16850406, 25651892, 28436820; Product type t : transporter" /codon_start=1 /transl_table=11 /product="malate (2-oxoglutarate) transporter" /protein_id="NP_388638.1" /db_xref="EnsemblGenomes-Gn:BSU07570" /db_xref="EnsemblGenomes-Tr:CAB12586" /db_xref="GOA:O34726" /db_xref="InterPro:IPR001898" /db_xref="InterPro:IPR030676" /db_xref="SubtiList:BG12951" /db_xref="UniProtKB/Swiss-Prot:O34726" /translation="MASEKDAGKQSAVKLVPLLITVAVGLIIWFIPAPSGLEPKAWHL FAIFVATIIGFISKPLPMGAIAIFALAVTALTGTLSIEDTLSGFGNKTIWLIVIAFFI SRGFIKTGLGARISYVFVQKFGKKTLGLSYSLLFSDLILSPAIPSNTARAGGIIFPII RSLSETFGSSPANGTERKIGAFLLKTGFQGNLITSAMFLTAMAANPLIAKLAHDVAGV DLTWTSWAIAAIVPGLVSLIITPLVIYKLYPPEIKETPDAAKIATEKLKEMGPFKKSE LSMVIVFLLVLVLWIFGGSFNIDATTTALIGLAVLLLSQVLTWDDIKKEQGAWDTLTW FAALVMLANFLNELGMVSWFSNAMKSSVSGFSWIVAFIILIVVYYYSHYFFASATAHI SAMYSAFLAVVVAAGAPPLLAALSLAFISNLFGSTTHYGSGAAPVFFGAGYIPQGKWW SIGFILSIVHIIVWLVIGGLWWKVLGIW*" /label="maeS CDS" gene 778959..780395 /gene="maeS" /locus_tag="BSU_07570" /old_locus_tag="BSU07570" /label="maeS gene" downshifts 780387 /Source="Nicolas_upshifts" /id="D378" /incds=0 /nref=56 /ntot=132 /MaxReadThrough="2.39993" /MaxDrop="5.36125" /score="40.3051497" /energy="-9.7" /TU="NA" /idTUdmin="U577" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" misc_feature 780486..780505 /Source="Nicolas_upshift_promotors" /id="U578" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2939 /SigmaFactorBS="tccttcgtaagaaaatggattttgaaaaatgagaaaattccc tgtgaaaAATGGTATGATCTAGGTAGAaaggacggctggtgctgtggtgaaaaagcgg t" /listShort="citS, citT, yflP" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 780497 /Source="Nicolas_upshifts" /id="U578" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2939 /SigmaFactorBS="tccttcgtaagaaaatggattttgaaaaatgagaaaattccc tgtgaaaAATGGTATGATCTAGGTAGAaaggacggctggtgctgtggtgaaaaagcgg t" /listShort="citS, citT, yflP" /GFF_Attribute="listLong" /label="upshifts" CDS 780522..782150 /gene="citS" /locus_tag="BSU_07580" /old_locus_tag="BSU07580" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:10972810, 11717295, 12949159, 16842348" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10972810, 11717295, 12949159, 16842348; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase" /protein_id="NP_388639.1" /db_xref="EnsemblGenomes-Gn:BSU07580" /db_xref="EnsemblGenomes-Tr:CAB12587" /db_xref="GOA:O34427" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR016120" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12576" /db_xref="UniProtKB/Swiss-Prot:O34427" /translation="MVKKRFHFSLQTKIMGLIAALLVFVIGVLTITLAVQHTQGERRQ AEQLAVQTARTISYMPPVKELIERKDGHAAQTQEVIEQMKEQTGAFAIYVLNEKGDIR SASGKSGLKKLERSREILFGGSHVSETKADGRRVIRGSAPIIKEQKGYSQVIGSVSVD FLQTETEQSIKKHLRNLSVIAVLVLLLGFIGAAVLAKSIRKDTLGLEPHEIAALYRER NAMLFAIREGIIATNREGVVTMMNVSAAEMLKLPEPVIHLPIDDVMPGAGLMSVLEKG EMLPNQEVSVNDQVFIINTKVMNQGGQAYGIVVSFREKTELKKLIDTLTEVRKYSEDL RAQTHEFSNKLYAILGLLELGEYDEAIDLIKEEYAIQNEQHDLLFHNIHSQQVQAILL GKISKASEKKVKLVIDENSSLAPLPAHIGLSHLITIIGNLIDNAFEAVAEQSVKEVLF FITDMGHDIVIEVSDTGPGVPPEKIEAVFERGYSSKGMRRGYGLANVKDSVRELGGWI ELANQKTGGAVFTVFIPKEKQRGNPFDSHRDCGG*" /label="citS CDS" gene 780522..782150 /gene="citS" /locus_tag="BSU_07580" /old_locus_tag="BSU07580" /label="citS gene" CDS 782122..782802 /gene="citT" /locus_tag="BSU_07590" /old_locus_tag="BSU07590" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10972810, 11717295, 12949159, 16842348" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10972810, 11717295, 12949159, 16842348; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator" /protein_id="NP_388640.1" /db_xref="EnsemblGenomes-Gn:BSU07590" /db_xref="EnsemblGenomes-Tr:CAB12588" /db_xref="GOA:O34534" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR013196" /db_xref="InterPro:IPR024187" /db_xref="InterPro:IPR028141" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12577" /db_xref="UniProtKB/Swiss-Prot:O34534" /translation="MIHIAIAEDDFRVAQIHERLIKQLDGFKIIGKAANAKETLALLK EHKADLLLLDIYMPDELGTALIPDIRSRFPEVDIMIITAATETRHLQEALRAGIAHYL IKPVTADKFRQVLLQYKEKRKLLMSQPEVSQSMIDHIFGNGVKTALPAEDLPTGINSI TLRKIKEALQTASEGLTAEELGEKMGASRTTARRYAEYLVSKEEARAELEYGIIGRPE RKYYLAAD*" /label="citT CDS" gene 782122..782802 /gene="citT" /locus_tag="BSU_07590" /old_locus_tag="BSU07590" /label="citT gene" CDS 782805..783764 /gene="yflP" /locus_tag="BSU_07600" /old_locus_tag="BSU07600" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11029430; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative tricarboxylate transporter component" /protein_id="NP_388641.2" /db_xref="EnsemblGenomes-Gn:BSU07600" /db_xref="EnsemblGenomes-Tr:CAB12589" /db_xref="GOA:O34439" /db_xref="InterPro:IPR005064" /db_xref="SubtiList:BG12950" /db_xref="UniProtKB/Swiss-Prot:O34439" /translation="MKKSIILLNILLIFMQGDIRQAAAPRLPDGPIEIVVPAEPSGGW DVTAQAIQSVLRQKQIVKDDVHIVYKSGGGGEKGWKYVNKSSKQTISMTSSLILSNDL LGQSKLKMSDFTPLAILSKEWQTVALPKGSALTNGKDVLNEINMHPGKVRIGFAPGFG NDDQLSFVRAADMYGIDPFDIQFSQYDSSEQLIQALIRHEIEAASMTLSEAKPYERNG DITLAAVTSDKRLPGFPNVPTWKEQGIPFVFSHWRGILGPKNMSEEEISYWDQALKKV TSSPEWKRKINEQDWESFYLNSRETKRFLEEQSAFYQSIMTGN*" /label="yflP CDS" gene 782805..783764 /gene="yflP" /locus_tag="BSU_07600" /old_locus_tag="BSU07600" /label="yflP gene" downshifts 783733 /Source="Nicolas_upshifts" /id="D379" /incds=0 /nref=76 /ntot=211 /MaxReadThrough="1.1681" /MaxDrop="6.31244" /score="10.4510496" /energy="-6.5" /TU="NA" /idTUdmin="U578" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 783856..783863 /Source="Nicolas_upshift_promotors" /id="U579" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.606393606393606" /psig="0.96003996003996" /xcortree=565 /SigmaFactorBS="aaaaaattaaaaatacaaaaaaaccaaatTATTTACTtgcgg ttggtttTCCCATACGATGGCAAAAAGgcaagacaaaaaggggagtaagggagaaaaa a" /listShort="S262, citM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 783876..783895 /Source="Nicolas_upshift_promotors" /id="U579" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.606393606393606" /psig="0.96003996003996" /xcortree=565 /SigmaFactorBS="aaaaaattaaaaatacaaaaaaaccaaatTATTTACTtgcgg ttggtttTCCCATACGATGGCAAAAAGgcaagacaaaaaggggagtaagggagaaaaa a" /listShort="S262, citM" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 783887..783959 /Source="Nicolas_S_feature" /locus_tag="new_834310_834382" /HighExp="M9-stat, SMMPr, SMM, T0.0H, LoTm, T1.0H, Pyr, T1.30H, Cold, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.96" /TUlongSig="NA" /TUlongPSig="NA" /label="S262" upshifts 783887 /Source="Nicolas_upshifts" /id="U579" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.606393606393606" /psig="0.96003996003996" /xcortree=565 /SigmaFactorBS="aaaaaattaaaaatacaaaaaaaccaaatTATTTACTtgcgg ttggtttTCCCATACGATGGCAAAAAGgcaagacaaaaaggggagtaagggagaaaaa a" /listShort="S262, citM" /GFF_Attribute="listLong" /label="upshifts" CDS 783960..785261 /gene="citM" /locus_tag="BSU_07610" /old_locus_tag="BSU07610" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12427932, 12533460, 12906362, 12949159, 15849754, 16842348, 16850406, 24415722, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12427932, 12533460, 12906362, 12949159, 15849754, 16842348, 16850406, 24415722, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="transporter of divalent metal ions/citrate complexes" /protein_id="NP_388642.1" /db_xref="EnsemblGenomes-Gn:BSU07610" /db_xref="EnsemblGenomes-Tr:CAB12590" /db_xref="GOA:P55069" /db_xref="InterPro:IPR004680" /db_xref="InterPro:IPR014738" /db_xref="SubtiList:BG11832" /db_xref="UniProtKB/Swiss-Prot:P55069" /translation="MLAILGFLMMLVFMALIMTKRLSVLTALVLTPIVFALIAGFGFT EVGDMMISGIQQVAPTAVMIMFAILYFGIMIDTGLFDPMVGKILSMVKGDPLKIVVGT AVLTMLVALDGDGSTTYMITTSAMLPLYLLLGIRPIILAGIAGVGMGIMNTIPWGGAT PRAASALGVDPAELTGPMIPVIASGMLCMVAVAYVLGKAERKRLGVIELKQPANANEP AAAVEDEWKRPKLWWFNLLLTLSLIGCLVSGKVSLTVLFVIAFCIALIVNYPNLEHQR QRIAAHSSNVLAIGSMIFAAGVFTGILTGTKMVDEMAISLVSMIPEQMGGLIPAIVAL TSGIFTFLMPNDAYFYGVLPILSETAVAYGVDKVEIARASIIGQPIHMLSPLVPSTHL LVGLVGVSIDDHQKFALKWAVLAVIVMTAIALLIGAISISV*" /label="citM CDS" gene 783960..785261 /gene="citM" /locus_tag="BSU_07610" /old_locus_tag="BSU07610" /label="citM gene" promotor_-35 785258..785264 /Source="Nicolas_upshift_promotors" /id="U580" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=920 /SigmaFactorBS="ggctatcgctctattgatcggtgcgatctctatttccgtATG ATAAttcaggcgtaatgACACACACTAACggcatacaacattccggaggtgtcattat g" /listShort="yflN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 785278..785289 /Source="Nicolas_upshift_promotors" /id="U580" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=920 /SigmaFactorBS="ggctatcgctctattgatcggtgcgatctctatttccgtATG ATAAttcaggcgtaatgACACACACTAACggcatacaacattccggaggtgtcattat g" /listShort="yflN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 785279 /Source="Nicolas_upshifts" /id="U580" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=920 /SigmaFactorBS="ggctatcgctctattgatcggtgcgatctctatttccgtATG ATAAttcaggcgtaatgACACACACTAACggcatacaacattccggaggtgtcattat g" /listShort="yflN" /GFF_Attribute="listLong" /label="upshifts" CDS 785317..786111 /gene="yflN" /locus_tag="BSU_07620" /old_locus_tag="BSU07620" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10972810, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent hydrolase" /protein_id="NP_388643.1" /db_xref="EnsemblGenomes-Gn:BSU07620" /db_xref="EnsemblGenomes-Tr:CAB12591" /db_xref="GOA:O34409" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG12949" /db_xref="UniProtKB/Swiss-Prot:O34409" /translation="MSDPYMPLTSVRSGAGFEAAKGVHGLTVQIANVYFIQLPSEPHS FVLIDAGMPQSAGVIVNEAKQRFGEGFQLKAIILTHGHFDHIGAIEEILEHWDVPVYI HSREMPYVTGKEDYPPARPDSKSGLVAKLSPLFPRHSIDISSHVQALPEDGSVPFLDE WMWIATPGHTPGHISLFRDDGRVLVAGDAVITVEQEKMADVLIQKQELHGPPAYFTPD TETAAESILKLAGLEPEALLTGHGIPMTGKNFRSDLTELANRLSSI*" /label="yflN CDS" gene 785317..786111 /gene="yflN" /locus_tag="BSU_07620" /old_locus_tag="BSU07620" /label="yflN gene" downshifts 786087 /Source="Nicolas_upshifts" /id="D380" /incds=0 /nref=2 /ntot=25 /MaxReadThrough="0.0114999999999998" /MaxDrop="3.05232" /score="38.3109333" /energy="-11.8" /TU="NA" /idTUdmin="U580" /TUdmin=132 /isTUend="FALSE" /label="downshifts" promotor_-35 786166..786169 /Source="Nicolas_upshift_promotors" /id="U581" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.509490509490509" /psig="0.995004995004995" /xcortree=2378 /SigmaFactorBS="attgttttccaggaagttgcagaaaaatcATTTgtcttgccg cttaaAAACGATACAATGAAAAGCAtgaagtgatgtgaaggggagagtttgttggaag a" /listShort="nosA, S263, yflK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 786184..786203 /Source="Nicolas_upshift_promotors" /id="U581" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.509490509490509" /psig="0.995004995004995" /xcortree=2378 /SigmaFactorBS="attgttttccaggaagttgcagaaaaatcATTTgtcttgccg cttaaAAACGATACAATGAAAAGCAtgaagtgatgtgaaggggagagtttgttggaag a" /listShort="nosA, S263, yflK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 786197 /Source="Nicolas_upshifts" /id="U581" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.509490509490509" /psig="0.995004995004995" /xcortree=2378 /SigmaFactorBS="attgttttccaggaagttgcagaaaaatcATTTgtcttgccg cttaaAAACGATACAATGAAAAGCAtgaagtgatgtgaaggggagagtttgttggaag a" /listShort="nosA, S263, yflK" /GFF_Attribute="listLong" /label="upshifts" CDS 786230..787321 /gene="nosA" /locus_tag="BSU_07630" /old_locus_tag="BSU07630" /EC_number="1.14.13.39" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11856757, 12220171, 16172391, 25643072, 25826316, 26062720" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11856757, 12220171, 16172391, 25643072, 25826316, 26062720; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="nitric-oxide synthase" /protein_id="NP_388644.2" /db_xref="EnsemblGenomes-Gn:BSU07630" /db_xref="EnsemblGenomes-Tr:CAB12592" /db_xref="GOA:O34453" /db_xref="InterPro:IPR004030" /db_xref="InterPro:IPR017142" /db_xref="InterPro:IPR036119" /db_xref="PDB:1M7V" /db_xref="PDB:1M7Z" /db_xref="PDB:2AMO" /db_xref="PDB:2AN0" /db_xref="PDB:2AN2" /db_xref="PDB:2FBZ" /db_xref="PDB:2FC1" /db_xref="PDB:2FC2" /db_xref="PDB:4D3I" /db_xref="PDB:4D3J" /db_xref="PDB:4D3K" /db_xref="PDB:4D3M" /db_xref="PDB:4D3N" /db_xref="PDB:4D3O" /db_xref="PDB:4D3T" /db_xref="PDB:4D3U" /db_xref="PDB:4D3V" /db_xref="PDB:4D7H" /db_xref="PDB:4D7I" /db_xref="PDB:4D7J" /db_xref="PDB:4LWA" /db_xref="PDB:4LWB" /db_xref="PDB:4UG5" /db_xref="PDB:4UG6" /db_xref="PDB:4UG7" /db_xref="PDB:4UG8" /db_xref="PDB:4UG9" /db_xref="PDB:4UGA" /db_xref="PDB:4UGB" /db_xref="PDB:4UGC" /db_xref="PDB:4UGD" /db_xref="PDB:4UGE" /db_xref="PDB:4UGF" /db_xref="PDB:4UGG" /db_xref="PDB:4UGH" /db_xref="PDB:4UGI" /db_xref="PDB:4UGJ" /db_xref="PDB:4UGK" /db_xref="PDB:4UGL" /db_xref="PDB:4UGM" /db_xref="PDB:4UGN" /db_xref="PDB:4UGO" /db_xref="PDB:4UGP" /db_xref="PDB:4UGQ" /db_xref="PDB:4UGR" /db_xref="PDB:4UGS" /db_xref="PDB:4UGT" /db_xref="PDB:4UGU" /db_xref="PDB:4UGV" /db_xref="PDB:4UGW" /db_xref="PDB:4UGX" /db_xref="PDB:4UGY" /db_xref="PDB:4UQR" /db_xref="PDB:4UQS" /db_xref="PDB:5G65" /db_xref="PDB:5G66" /db_xref="PDB:5G67" /db_xref="PDB:5G68" /db_xref="PDB:5G69" /db_xref="PDB:5G6A" /db_xref="PDB:5G6B" /db_xref="PDB:5G6C" /db_xref="PDB:5G6D" /db_xref="PDB:5G6E" /db_xref="PDB:5G6F" /db_xref="PDB:5G6G" /db_xref="PDB:5G6H" /db_xref="PDB:5G6I" /db_xref="PDB:5G6J" /db_xref="PDB:5G6K" /db_xref="PDB:5G6L" /db_xref="PDB:5G6M" /db_xref="PDB:5G6N" /db_xref="PDB:5G6O" /db_xref="PDB:5G6P" /db_xref="PDB:5G6Q" /db_xref="SubtiList:BG12948" /db_xref="UniProtKB/Swiss-Prot:O34453" /translation="MEEKEILWNEAKAFIAACYQELGKEEEVKDRLADIKSEIDLTGS YVHTKEELEHGAKMAWRNSNRCIGRLFWNSLNVIDRRDVRTKEEVRDALFHHIETATN NGKIRPTITIFPPEEKGEKQVEIWNHQLIRYAGYESDGERIGDPASCSLTAACEELGW RGERTDFDLLPLIFRMKGDEQPVWYELPRSLVIEVPITHPDIEAFSDLELKWYGVPII SDMKLEVGGIHYNAAPFNGWYMGTEIGARNLADEKRYDKLKKVASVIGIAADYNTDLW KDQALVELNKAVLHSYKKQGVSIVDHHTAASQFKRFEEQEEEAGRKLTGDWTWLIPPI SPAATHIFHRSYDNSIVKPNYFYQDKPYE*" /label="nosA CDS" gene 786230..787321 /gene="nosA" /locus_tag="BSU_07630" /old_locus_tag="BSU07630" /label="nosA gene" CDS complement(787312..787587) /gene="acyP" /locus_tag="BSU_07640" /old_locus_tag="BSU07640" /EC_number="3.6.1.7" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:20447399" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20447399; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acylphosphatase" /protein_id="NP_388645.1" /db_xref="EnsemblGenomes-Gn:BSU07640" /db_xref="EnsemblGenomes-Tr:CAB12593" /db_xref="GOA:O35031" /db_xref="InterPro:IPR001792" /db_xref="InterPro:IPR017968" /db_xref="InterPro:IPR020456" /db_xref="InterPro:IPR036046" /db_xref="PDB:2FHM" /db_xref="PDB:2HLT" /db_xref="PDB:2HLU" /db_xref="PDB:3BR8" /db_xref="SubtiList:BG12947" /db_xref="UniProtKB/Swiss-Prot:O35031" /translation="MLQYRIIVDGRVQGVGFRYFVQMEADKRKLAGWVKNRDDGRVEI LAEGPENALQSFVEAVKNGSPFSKVTDISVTESRSLEGHHRFSIVYS*" /label="acyP CDS" gene complement(787312..787587) /gene="acyP" /locus_tag="BSU_07640" /old_locus_tag="BSU07640" /label="acyP gene" S_feature 787322..787653 /Source="Nicolas_S_feature" /locus_tag="new_837745_838076" /HighExp="C90, BI, Paraq, LBGexp, Oxctl, M0t45, G150, M40t45, G135, H2O2" /AntisenseName="yflL" /AntisenseCor="0.38657275217332299" /AntisenseRegPval="-10.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S263" promotor_-10 complement(787601..787620) /Source="Nicolas_upshift_promotors" /id="U582" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.818181818181818" /psig="0.998001998001998" /xcortree=3152 /SigmaFactorBS="ctgaatagcgctcttgtttcatacaaacacatcCCCTTTACa ggttgtaaaatgaTTGATTATCATAAAAAGAAAaggtggtttttacatgcttcaatac c" /listShort="yflL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(787615) /Source="Nicolas_upshifts" /id="U582" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.818181818181818" /psig="0.998001998001998" /xcortree=3152 /SigmaFactorBS="ctgaatagcgctcttgtttcatacaaacacatcCCCTTTACa ggttgtaaaatgaTTGATTATCATAAAAAGAAAaggtggtttttacatgcttcaatac c" /listShort="yflL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(787635..787642) /Source="Nicolas_upshift_promotors" /id="U582" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.818181818181818" /psig="0.998001998001998" /xcortree=3152 /SigmaFactorBS="ctgaatagcgctcttgtttcatacaaacacatcCCCTTTACa ggttgtaaaatgaTTGATTATCATAAAAAGAAAaggtggtttttacatgcttcaatac c" /listShort="yflL" /GFF_Attribute="listLong" /label="promotor_-35" CDS 787654..788319 /gene="yflK" /locus_tag="BSU_07650" /old_locus_tag="BSU07650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11886751; Product type c: carrier" /codon_start=1 /transl_table=11 /product="putative sulfur carrier" /protein_id="NP_388646.1" /db_xref="EnsemblGenomes-Gn:BSU07650" /db_xref="EnsemblGenomes-Tr:CAB12594" /db_xref="GOA:O34542" /db_xref="InterPro:IPR005163" /db_xref="InterPro:IPR005302" /db_xref="InterPro:IPR011037" /db_xref="SubtiList:BG12946" /db_xref="UniProtKB/Swiss-Prot:O34542" /translation="MKQERYSVLSLNLGKPQTLEYDGKKIETGIMKRPAKSAVMLYRE NFEGDGQADLVNHGGPDKAVCVYPAEHYPFWEEFLSRPLSNAAFGENLTVAGLTEENV CIGDVFRLDEAVVQVSQPRQPCVKLAKKFGVKEMVLKVQQTGYTGFYFRVLEEGRVSP GANLELLSRGEKGISVQFANRINYHDAKNLTAIERILSEAALSESWRASFMKKKDRLL PVE*" /label="yflK CDS" gene 787654..788319 /gene="yflK" /locus_tag="BSU_07650" /old_locus_tag="BSU07650" /label="yflK gene" CDS complement(788360..788497) /gene="yflJ" /locus_tag="BSU_07660" /old_locus_tag="BSU07660" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388647.1" /db_xref="EnsemblGenomes-Gn:BSU07660" /db_xref="EnsemblGenomes-Tr:CAB12595" /db_xref="InterPro:IPR022580" /db_xref="SubtiList:BG12945" /db_xref="UniProtKB/Swiss-Prot:O34345" /translation="MHYGSKGWYVAELKKQGITHHEGRKLQSYKTYFLANLLESKKKQ S*" /label="yflJ CDS" gene complement(788360..788497) /gene="yflJ" /locus_tag="BSU_07660" /old_locus_tag="BSU07660" /label="yflJ gene" downshifts complement(788374) /Source="Nicolas_upshifts" /id="D381" /incds=0 /nref=136 /ntot=260 /MaxReadThrough="0.0927600000000002" /MaxDrop="8.10929" /score="29.8336543" /energy="-14.8" /TU="NA" /idTUdmin="U583" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" S_feature complement(788498..788628) /Source="Nicolas_S_feature" /locus_tag="new_838921_839051_c" /HighExp="S4, S7, S8, S6, S5, S3, B36, BT, LoTm, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="0.967, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S264" promotor_-10 complement(788614..788632) /Source="Nicolas_upshift_promotors" /id="U583" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=1134 /SigmaFactorBS="ttggcgttgtcatgatcaaactaaccggccattaaATCATAt tcggcttttgctccGCATATACATTCAGAAGAAcattcgtacatctagtgcgaaaggc t" /listShort="S264, yflJ" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 788624..788629 /Source="Nicolas_upshift_promotors" /id="U584" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1109 /SigmaFactorBS="gaaaactgagcctttcgcactagatgtacgaatgttcttctg aaTGTATAtgcggagcaaaagccGAATATGATTTAATGGCCGgttagtttgatcatga c" /listShort="S265" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(788628) /Source="Nicolas_upshifts" /id="U583" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=1134 /SigmaFactorBS="ttggcgttgtcatgatcaaactaaccggccattaaATCATAt tcggcttttgctccGCATATACATTCAGAAGAAcattcgtacatctagtgcgaaaggc t" /listShort="S264, yflJ" /GFF_Attribute="listLong" /label="upshifts" S_feature 788639..789703 /Source="Nicolas_S_feature" /locus_tag="new_839062_840126" /HighExp="S8, S6, S5, S7, S4, S3, BT, B36, C90, T5.0H" /AntisenseName="mapB" /AntisenseCor="-0.26446079057314398" /AntisenseRegPval="-5" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S265" upshifts 788640 /Source="Nicolas_upshifts" /id="U584" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1109 /SigmaFactorBS="gaaaactgagcctttcgcactagatgtacgaatgttcttctg aaTGTATAtgcggagcaaaagccGAATATGATTTAATGGCCGgttagtttgatcatga c" /listShort="S265" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 788645..788663 /Source="Nicolas_upshift_promotors" /id="U584" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1109 /SigmaFactorBS="gaaaactgagcctttcgcactagatgtacgaatgttcttctg aaTGTATAtgcggagcaaaagccGAATATGATTTAATGGCCGgttagtttgatcatga c" /listShort="S265" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(788648..788653) /Source="Nicolas_upshift_promotors" /id="U583" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=1134 /SigmaFactorBS="ttggcgttgtcatgatcaaactaaccggccattaaATCATAt tcggcttttgctccGCATATACATTCAGAAGAAcattcgtacatctagtgcgaaaggc t" /listShort="S264, yflJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(788654..788809) /gene="yflI" /locus_tag="BSU_07670" /old_locus_tag="BSU07670" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved membrane protein" /protein_id="NP_388648.1" /db_xref="EnsemblGenomes-Gn:BSU07670" /db_xref="EnsemblGenomes-Tr:CAB12596" /db_xref="GOA:O34905" /db_xref="SubtiList:BG12944" /db_xref="UniProtKB/Swiss-Prot:O34905" /translation="MWFIIFGIIFFIEGIIMTVYGVKKKNGMLTYIGIVFAIMTFGVV MIKLTGH*" /label="yflI CDS" gene complement(788654..788809) /gene="yflI" /locus_tag="BSU_07670" /old_locus_tag="BSU07670" /label="yflI gene" S_feature complement(788810..788915) /Source="Nicolas_S_feature" /locus_tag="new_839233_839338_c" /HighExp="Etha, Salt, Diami, dia15, H2O2, Cold, G135, Paraq, LPhT, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S266" CDS complement(788916..789230) /gene="yflH" /locus_tag="BSU_07680" /old_locus_tag="BSU07680" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 1070366, 1266368; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_388649.1" /db_xref="EnsemblGenomes-Gn:BSU07680" /db_xref="EnsemblGenomes-Tr:CAB12597" /db_xref="InterPro:IPR021637" /db_xref="PDB:3D0W" /db_xref="SubtiList:BG12943" /db_xref="UniProtKB/Swiss-Prot:O34306" /translation="MNRDQEKIQIENEMNAMHGTIKEDILKDFEEFKGYLKKQVNRGK KLGLDDGKLVKSAAILGDYLAKHEEPQNGEEMLLQELWSVADEDEKEHLAQLLVKLVD KQ*" /label="yflH CDS" gene complement(788916..789230) /gene="yflH" /locus_tag="BSU_07680" /old_locus_tag="BSU07680" /label="yflH gene" S_feature complement(789231..789311) /Source="Nicolas_S_feature" /locus_tag="new_839654_839734_c" /HighExp="dia5, dia15, Diami, LBGtran, LPhT, H2O2, Etha, Lbtran, M40t45, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S267" CDS complement(789312..790061) /gene="mapB" /locus_tag="BSU_07690" /old_locus_tag="BSU07690" /EC_number="3.4.11.18" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16207374" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16207374; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methionine aminopeptidase B" /protein_id="NP_388650.1" /db_xref="EnsemblGenomes-Gn:BSU07690" /db_xref="EnsemblGenomes-Tr:CAB12598" /db_xref="GOA:O34484" /db_xref="InterPro:IPR000994" /db_xref="InterPro:IPR001714" /db_xref="InterPro:IPR002467" /db_xref="InterPro:IPR036005" /db_xref="SubtiList:BG12942" /db_xref="UniProtKB/Swiss-Prot:O34484" /translation="MIVTNDQELEGLKKIGRIVALAREEMKRKAEPGMSTKDLDLIGK AVLDEHGAVSAPEKEYDFPGVTCISVNDEVAHGIPSTSKILKAGDLVNIDISAEFGGF YSDTGISFVLGEGEERLHKLCQCAENAFQKGLQQAKAGKRQNQIGRAVYHEARSQGFT VIKTLTGHGIGRSLHEAPNHIMNYYDPFDNALFKNGTVIALEPFISTKAETIVEAGDG WTFKTPDKSMVAQVEHTIVITKDEPIILTKL*" /label="mapB CDS" gene complement(789312..790061) /gene="mapB" /locus_tag="BSU_07690" /old_locus_tag="BSU07690" /label="mapB gene" promotor_-10 complement(790090..790109) /Source="Nicolas_upshift_promotors" /id="U585" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.786213786213786" /psig=1 /xcortree=1950 /SigmaFactorBS="cccgggggtatttcttttttcccaggtccgtgtgTTTCCTAT TtttaagacagtTGTGGTAAGCTTAATCTAGAttatttaaaaagaaagcgggaatgac a" /listShort="mapB, S267, yflH, S266, yflI, S264, yflJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(790103) /Source="Nicolas_upshifts" /id="U585" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.786213786213786" /psig=1 /xcortree=1950 /SigmaFactorBS="cccgggggtatttcttttttcccaggtccgtgtgTTTCCTAT TtttaagacagtTGTGGTAAGCTTAATCTAGAttatttaaaaagaaagcgggaatgac a" /listShort="mapB, S267, yflH, S266, yflI, S264, yflJ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(790105..791241) /Source="Nicolas_S_feature" /locus_tag="new_840528_841664_c" /HighExp="S6, S8, S7, S5, BT, C30, Paraq, B36, G180, Pyr" /AntisenseName="nagP" /AntisenseCor="0.180776000778922" /AntisenseRegPval="-2.5" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S268" promotor_-35 complement(790121..790129) /Source="Nicolas_upshift_promotors" /id="U585" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.786213786213786" /psig=1 /xcortree=1950 /SigmaFactorBS="cccgggggtatttcttttttcccaggtccgtgtgTTTCCTAT TtttaagacagtTGTGGTAAGCTTAATCTAGAttatttaaaaagaaagcgggaatgac a" /listShort="mapB, S267, yflH, S266, yflI, S264, yflJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 790172..790173 /Source="Nicolas_upshift_promotors" /id="U586" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.493506493506494" /psig="0.995004995004995" /xcortree=1559 /SigmaFactorBS="gacctgggaaaaaagaaatacccccgggaaaattggTAtaga tcactagatatcttaTATGGTATATTTGAAAAAAAagggtatgagggggatgggtatg c" /listShort="nagP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 790193..790212 /Source="Nicolas_upshift_promotors" /id="U586" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.493506493506494" /psig="0.995004995004995" /xcortree=1559 /SigmaFactorBS="gacctgggaaaaaagaaatacccccgggaaaattggTAtaga tcactagatatcttaTATGGTATATTTGAAAAAAAagggtatgagggggatgggtatg c" /listShort="nagP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 790196 /Source="Nicolas_upshifts" /id="U586" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.493506493506494" /psig="0.995004995004995" /xcortree=1559 /SigmaFactorBS="gacctgggaaaaaagaaatacccccgggaaaattggTAtaga tcactagatatcttaTATGGTATATTTGAAAAAAAagggtatgagggggatgggtatg c" /listShort="nagP" /GFF_Attribute="listLong" /label="upshifts" CDS 790233..791591 /gene="nagP" /locus_tag="BSU_07700" /old_locus_tag="BSU07700" /function="16.11: Scavenge (Catabolism)" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15849754, 16850406, 8246840; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) N-acetylglucosamine-specific enzyme IICB component" /protein_id="NP_388651.1" /db_xref="EnsemblGenomes-Gn:BSU07700" /db_xref="EnsemblGenomes-Tr:CAB12599" /db_xref="GOA:O34521" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR010974" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="SubtiList:BG12941" /db_xref="UniProtKB/Swiss-Prot:O34521" /translation="MLSFLQKLGKSFMLPIAVLPAVGIILALGREDVFNIPFVYQAGT AVFDHLPLIFAIGIAIGISKDSNGAAGLSGAISYLMLDAATKTIDKTNNMAVFGGIIA GLIAGYTYNRFKDTKLPEYLGFFSGRRLVPILTAIITIILAGIFGVVWPPIQSCINSF GEWMLGLGGIGAGIFGLFNRLLIPLGLHHVLNNIFWFQFGEYNGVTGDLARFFAKDPT AGTYMTGFFPIMMFGLPAACLAMVVTAKPSKRKATAGMMIGFALTAFITGITEPIEFA FMFLSPLLYAVHAVLTGLSLFIVNWLGIRSGFSFSAGAIDYVLSYGIAEKPLLLLLVG ICYAAVYFIVFYVLIKALNLKTPGREDDDVDEVLDENTVQDVNENIMLKGLGGKENLQ TIDHCATRLRLTVKDTALVDEALLKKAGAKGVVKSGGQSVQVIIGPNVEFAAEELRAA VK*" /label="nagP CDS" gene 790233..791591 /gene="nagP" /locus_tag="BSU_07700" /old_locus_tag="BSU07700" /label="nagP gene" promotor_-10 complement(791227..791246) /Source="Nicolas_upshift_promotors" /id="U587" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1378 /SigmaFactorBS="gcgtttttaaattcaaagccttaatcagtacaTAAAACACGA taaagtatactgcCGCATAGCATATACCTACCAaaagcagaagcagcggtttttccgc g" /listShort="S268, mapB, S267, yflH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(791241) /Source="Nicolas_upshifts" /id="U587" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1378 /SigmaFactorBS="gcgtttttaaattcaaagccttaatcagtacaTAAAACACGA taaagtatactgcCGCATAGCATATACCTACCAaaagcagaagcagcggtttttccgc g" /listShort="S268, mapB, S267, yflH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(791260..791269) /Source="Nicolas_upshift_promotors" /id="U587" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1378 /SigmaFactorBS="gcgtttttaaattcaaagccttaatcagtacaTAAAACACGA taaagtatactgcCGCATAGCATATACCTACCAaaagcagaagcagcggtttttccgc g" /listShort="S268, mapB, S267, yflH" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 791477 /Source="Nicolas_upshifts" /id="D382" /incds=1 /nref=1 /ntot=106 /MaxReadThrough="3.67421" /MaxDrop="3.12268" /score="44.7832762" /energy="-16.9" /TU="U586" /idTUdmin="U586" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" downshifts 791587 /Source="Nicolas_upshifts" /id="D383" /incds=0 /nref=2 /ntot=87 /MaxReadThrough="2.54331" /MaxDrop="3.17508" /score="44.7832762" /energy="-16.9" /TU="NA" /idTUdmin="U586" /TUdmin=22 /isTUend="TRUE" /label="downshifts" CDS complement(791624..793573) /gene="ltaSB" /locus_tag="BSU_07710" /old_locus_tag="BSU07710" /function="16.1: Circulate" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10658653, 21255105" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10658653, 21255105; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enzyme responsible for polyglycerolphosphate LTAsynthesis" /protein_id="NP_388652.1" /db_xref="EnsemblGenomes-Gn:BSU07710" /db_xref="EnsemblGenomes-Tr:CAB12600" /db_xref="GOA:O34952" /db_xref="InterPro:IPR000917" /db_xref="InterPro:IPR012160" /db_xref="InterPro:IPR017849" /db_xref="InterPro:IPR017850" /db_xref="PDB:2W8D" /db_xref="SubtiList:BG12940" /db_xref="UniProtKB/Swiss-Prot:O34952" /translation="MKTFIKERGLAFFLIAVVLLWIKTYVGYVLNFNLGIDNTIQKIL LFVNPLSSSLFFLGFGLLFKKKLQQTAIIVIHFLMSFLLYANIVYYRFFNDFITIPVI MQAKTNGGQLGDSAFSLMRPTDAFYFIDTIILIILAIKVNKPAETSSKKSFRIIFASS ILVFLINLAVAESDRPELLTRSFDRNYLVKYLGTYNFTIYDAVQNIKSNSQRALADSS DVTEVENYMKANYDVPNNVYFGKAEGKNVIYVSLESLQSFIIDYKIDGKEVTPFLNKL AHDNETFYFDNFFHQTGQGKTSDAEFMMENSLYPLAQGSVFVNKAQNTLQSVPAILKS KNYTSATFHGNTQTFWNRNEMYKAEGIDKFFDSAYYDMNEENTKNYGMKDKPFFKESM PLLESLPQPFYTKFITLSNHFPFGMDEGDTDFPAGDFGDSVVDNYFQSAHYLDQSIEQ FFNDLKKDGLYDKSIIVMYGDHYGISENHNKAMAKVLGKDEITDYDNAQLQRVPLFIH AAGVKGEKVHKYAGDVDVAPTILHLLGVDTKDYLMSGSDILSKEHREVIPFRNGDFIS PKYTKISGKYYDTKTGKELDESEVDKSEDSLVKKELEMSDKIINGDLLRFYEPKGFKK VNPSDYDYTKHDEDSSETSKDNEDK*" /label="ltaSB CDS" gene complement(791624..793573) /gene="ltaSB" /locus_tag="BSU_07710" /old_locus_tag="BSU07710" /label="ltaSB gene" downshifts complement(791641) /Source="Nicolas_upshifts" /id="D384" /incds=0 /nref=219 /ntot=250 /MaxReadThrough="1.71031" /MaxDrop="6.08461" /score="43.6427282" /energy="-15.9" /TU="NA" /idTUdmin="U589" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 792683..792689 /Source="Nicolas_upshift_promotors" /id="U588" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=153 /SigmaFactorBS="acagagagttttccatcataaattcagcatcagaTGTTTTAc cttgtcccgtttggTGGAAAAAGTTATCAAAGTagaacgtttcgttatcatgtgccag t" /listShort="S269, yflD, yflB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 792705..792723 /Source="Nicolas_upshift_promotors" /id="U588" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=153 /SigmaFactorBS="acagagagttttccatcataaattcagcatcagaTGTTTTAc cttgtcccgtttggTGGAAAAAGTTATCAAAGTagaacgtttcgttatcatgtgccag t" /listShort="S269, yflD, yflB" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 792709..793673 /Source="Nicolas_S_feature" /locus_tag="new_843132_844096" /HighExp="Etha, Salt, Sw, Gly, C30, M9-stat, S8, B60, BC, S7" /AntisenseName="yflE" /AntisenseCor="-0.385555454026206" /AntisenseRegPval="-10.199999999999999" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S269" upshifts 792709 /Source="Nicolas_upshifts" /id="U588" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=153 /SigmaFactorBS="acagagagttttccatcataaattcagcatcagaTGTTTTAc cttgtcccgtttggTGGAAAAAGTTATCAAAGTagaacgtttcgttatcatgtgccag t" /listShort="S269, yflD, yflB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(793574..793648) /Source="Nicolas_S_feature" /locus_tag="new_843997_844071_c" /HighExp="Paraq, H2O2, LBGexp, G150, G135, G180, Lbexp, C30, LPhT, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S270" promotor_-10 complement(793625..793644) /Source="Nicolas_upshift_promotors" /id="U589" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.956043956043956" /psig=1 /xcortree=2614 /SigmaFactorBS="gattcgacggcgtttttcgccactttctccctcatacgattt tcACTTTtctaatctgctgattCGTGTTATATTGGATACGTTcgttttttctatcgtt t" /listShort="S270, yflE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(793648) /Source="Nicolas_upshifts" /id="U589" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.956043956043956" /psig=1 /xcortree=2614 /SigmaFactorBS="gattcgacggcgtttttcgccactttctccctcatacgattt tcACTTTtctaatctgctgattCGTGTTATATTGGATACGTTcgttttttctatcgtt t" /listShort="S270, yflE" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(793650..794172) /Source="Nicolas_S_feature" /locus_tag="new_844073_844595_c" /HighExp="S3, LoTm, S7, S4, S5, S8, S6, M9-stat, C30, Pyr" /AntisenseName="yflD" /AntisenseCor="0.24383322556613099" /AntisenseRegPval="-4.3" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S271" promotor_-35 complement(793660..793664) /Source="Nicolas_upshift_promotors" /id="U589" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.956043956043956" /psig=1 /xcortree=2614 /SigmaFactorBS="gattcgacggcgtttttcgccactttctccctcatacgattt tcACTTTtctaatctgctgattCGTGTTATATTGGATACGTTcgttttttctatcgtt t" /listShort="S270, yflE" /GFF_Attribute="listLong" /label="promotor_-35" CDS 793674..793811 /gene="yflD" /locus_tag="BSU_07720" /old_locus_tag="BSU07720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_388653.1" /db_xref="EnsemblGenomes-Gn:BSU07720" /db_xref="EnsemblGenomes-Tr:CAB12601" /db_xref="SubtiList:BG12939" /db_xref="UniProtKB/Swiss-Prot:O34489" /translation="MREKVAKNAVESTFRFDITKCKTRYLSRNKGIKWYIENCMIKYK V*" /label="yflD CDS" gene 793674..793811 /gene="yflD" /locus_tag="BSU_07720" /old_locus_tag="BSU07720" /label="yflD gene" upshifts 793789 /Source="Nicolas_upshifts" /id="U590" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.895104895104895" /psig="0.952047952047952" /xcortree=589 /SigmaFactorBS="ccaaatgtaaaacaaggtatctttctagaaataaaggaataa aatggtacattgagaattgTATGATAAAATATAAGGTATagataaaaagaggtgaaat g" /listShort="yflB" /listLong="yflA, S272" /label="upshifts" misc_feature 793790..793809 /Source="Nicolas_upshift_promotors" /id="U590" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.895104895104895" /psig="0.952047952047952" /xcortree=589 /SigmaFactorBS="ccaaatgtaaaacaaggtatctttctagaaataaaggaataa aatggtacattgagaattgTATGATAAAATATAAGGTATagataaaaagaggtgaaat g" /listShort="yflB" /listLong="yflA, S272" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 793830..794222 /gene="yflB" /locus_tag="BSU_07735" /old_locus_tag="BSU07735" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388655.2" /db_xref="EnsemblGenomes-Gn:BSU07735" /db_xref="EnsemblGenomes-Tr:CAB12603" /db_xref="InterPro:IPR018961" /db_xref="SubtiList:BG12937" /db_xref="UniProtKB/Swiss-Prot:O34887" /translation="MDFSHIVSEDKIKRAIKDGDFQNLPGMGKPLPKDDAAHLPESLR MGYRILKNAGMAEDEGALKKELMTIDHLIEKCYDEKEREQLIRKKSEKQLLLDKLVDK KGMFSKPASAFYKNKVYDRLGRNRPSSS*" /label="yflB CDS" gene 793830..794222 /gene="yflB" /locus_tag="BSU_07735" /old_locus_tag="BSU07735" /label="yflB gene" promotor_-10 complement(794170..794188) /Source="Nicolas_upshift_promotors" /id="U591" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=999 /SigmaFactorBS="cgccatcctgcagacaagacaaatcagctggaagaaGGTCTG tttcgtccaagccggTCATATACTTTATTCTTATaaaaagcggatgctggctttgaaa a" /listShort="S271" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(794185) /Source="Nicolas_upshifts" /id="U591" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=999 /SigmaFactorBS="cgccatcctgcagacaagacaaatcagctggaagaaGGTCTG tttcgtccaagccggTCATATACTTTATTCTTATaaaaagcggatgctggctttgaaa a" /listShort="S271" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(794204..794209) /Source="Nicolas_upshift_promotors" /id="U591" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=999 /SigmaFactorBS="cgccatcctgcagacaagacaaatcagctggaagaaGGTCTG tttcgtccaagccggTCATATACTTTATTCTTATaaaaagcggatgctggctttgaaa a" /listShort="S271" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 794291..794297 /Source="Nicolas_upshift_promotors" /id="U592" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=234 /SigmaFactorBS="aaaagccatcctttttatgttccaagttctatgtcaaaaGGT TTATgtttttccatctatGGGAAATGATTCATAAACGaaaaaagggtgatgggatgga a" /listShort="yflA, S272" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 794312..794330 /Source="Nicolas_upshift_promotors" /id="U592" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=234 /SigmaFactorBS="aaaagccatcctttttatgttccaagttctatgtcaaaaGGT TTATgtttttccatctatGGGAAATGATTCATAAACGaaaaaagggtgatgggatgga a" /listShort="yflA, S272" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 794312 /Source="Nicolas_upshifts" /id="U592" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=234 /SigmaFactorBS="aaaagccatcctttttatgttccaagttctatgtcaaaaGGT TTATgtttttccatctatGGGAAATGATTCATAAACGaaaaaagggtgatgggatgga a" /listShort="yflA, S272" /GFF_Attribute="listLong" /label="upshifts" CDS 794347..795762 /gene="yflA" /locus_tag="BSU_07750" /old_locus_tag="BSU07750" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative aminoacid transporter" /protein_id="NP_388656.1" /db_xref="EnsemblGenomes-Gn:BSU07750" /db_xref="EnsemblGenomes-Tr:CAB12604" /db_xref="GOA:O34708" /db_xref="InterPro:IPR001463" /db_xref="SubtiList:BG12936" /db_xref="UniProtKB/Swiss-Prot:O34708" /translation="MERLLVWIEHISDWLWGPPLIILLTGTGLYFTILLKGFQFRYPL YIFKQTIGSVGKKPKGEGTVTPLQALTSALSSTIGAANIVGVPAAIMFGGPGAVFWMW LIALFAMAIKFSESVLAVHYREKNEQGEYVGGPMYYITKGLRMKWLGVFFSVALIVEL IPSIMVQGNSVSVSLAETFSFNKIYAGIGIAFLIGLVVIGGVKRIGKVTEFVVPLMAG AYAGAGLLIVLMNLSSVPAFFSLVFSNAFTSSSAVGGFAGAALAETVRWGFARGLYSN EAGMGTAPIAHAAAMTDHPVRQGFWSVIGIVIDTLIICTTTAFIVLASGVWTGKNASN DPAALTTAAFQHYFGSGGGYFVSVSLVFFVVSTIMVVIFYGVKQAEFLFGRLAGHVIK FVYLAAIIIGAAGGAKAIWGVLDLALVFIVVPNVIALLLLSRKVKALYTEFFTSEQYY LKDIRKTKQKPVYPTKEAKNS*" /label="yflA CDS" gene 794347..795762 /gene="yflA" /locus_tag="BSU_07750" /old_locus_tag="BSU07750" /label="yflA gene" downshifts complement(794348) /Source="Nicolas_upshifts" /id="D385" /incds=0 /nref=4 /ntot=16 /MaxReadThrough="0.76492" /MaxDrop="4.20973" /score="43.6427282" /energy="-15.9" /TU="NA" /idTUdmin="U593" /TUdmin=22 /isTUend="TRUE" /label="downshifts" promotor_no_box complement(794374..794474) /Source="Nicolas_upshift_promotors" /id="U593" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.723276723276723" /psig="0.006993006993007" /xcortree=122 /SigmaFactorBS="ggatagcgaaattgaaaacctttcagcaaaatagtgaaatac aagcccgtccccgtcagcaggatgattagcggcggaccccacagccaatcagatatat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(794414) /Source="Nicolas_upshifts" /id="U593" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.723276723276723" /psig="0.006993006993007" /xcortree=122 /SigmaFactorBS="ggatagcgaaattgaaaacctttcagcaaaatagtgaaatac aagcccgtccccgtcagcaggatgattagcggcggaccccacagccaatcagatatat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(795759..796835) /gene="yfkT" /locus_tag="BSU_07760" /old_locus_tag="BSU07760" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10762253, 15849754, 16850406, 23625846; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative spore germination integral inner membrane transporter" /protein_id="NP_388657.1" /db_xref="EnsemblGenomes-Gn:BSU07760" /db_xref="EnsemblGenomes-Tr:CAB12605" /db_xref="GOA:O34573" /db_xref="InterPro:IPR004761" /db_xref="SubtiList:BG12935" /db_xref="UniProtKB/Swiss-Prot:O34573" /translation="MDKTSAYQGLFFGALYTLAVGLKHAPILMIESAKQNAWHSYILG VVIVIPALWLMHRLMKKHQDKNIYELLSDSSPIAGRIIILLFSLYFLLINAHDIRFFI NLINILFLPRTPMAVLGGVIIFVAICIAREGKETLTRMAQIFLFPFGILVLFLPFTLA TQIELQNLTPVFEGLIPYLQSGYYAFGTMGELIILPLLFSNRSVPLKYTIFAILLGAL LLAVMLFSSISVFGPNLTSTFFDPAYMVIRQIRITDFLDRSDLIIAAFWIPVIMVKIA GSLYIVVYGLSFLHSKIDPKAMYTPTGMFSVVCGFWFFLNTNQLIDFNRIKPIINVVI SLLLPLLIYLIIKSKALFGAKAKH*" /label="yfkT CDS" gene complement(795759..796835) /gene="yfkT" /locus_tag="BSU_07760" /old_locus_tag="BSU07760" /label="yfkT gene" S_feature 795763..799129 /Source="Nicolas_S_feature" /locus_tag="new_846186_849552" /HighExp="Salt, Sw, Etha, LoTm, B36, Heat, LPhT, BC, T0.30H, H2O2" /AntisenseName="yfkR" /AntisenseCor="-1.3937740774571999E-3" /AntisenseRegPval=0 /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.952" /label="S272" CDS complement(796859..797059) /gene="yfkS" /locus_tag="BSU_07770" /old_locus_tag="BSU07770" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23625846; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="putative spore germination D protein" /protein_id="NP_388658.1" /db_xref="EnsemblGenomes-Gn:BSU07770" /db_xref="EnsemblGenomes-Tr:CAB12606" /db_xref="GOA:O35036" /db_xref="SubtiList:BG12934" /db_xref="UniProtKB/Swiss-Prot:O35036" /translation="MISYIVQTLIVCIAIYAYEWKNFRSANNLTKWAFSLLIAGSAFL WIYMRVNPLLPRLGHLFKYIPF*" /label="yfkS CDS" gene complement(796859..797059) /gene="yfkS" /locus_tag="BSU_07770" /old_locus_tag="BSU07770" /label="yfkS gene" CDS complement(797075..798229) /gene="yfkR" /locus_tag="BSU_07780" /old_locus_tag="BSU07780" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10762253, 23625846; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative spore germination protein" /protein_id="NP_388659.1" /db_xref="EnsemblGenomes-Gn:BSU07780" /db_xref="EnsemblGenomes-Tr:CAB12607" /db_xref="GOA:O35028" /db_xref="InterPro:IPR008844" /db_xref="SubtiList:BG12933" /db_xref="UniProtKB/Swiss-Prot:O35028" /translation="MKKTIYKCVLPLLICILLTGCWDRTEINDIAFVVSSAIDKKKDQ YRVAMQIPLVGQLGGQTGGGGGTAGSKTWYVDSASGTTIREANNKLQTSLSRTINTSH RRTVIIGEDMARDGVAPVFDILTRNPQNRLTALILVSRGEARDILNTDVQLEQFPAEM IRELAIIATSRPVFLSRFMSDLVEIGSDPYAPVISASKTKPGGKGKSNLKIDGLAIFK KDRLMDIFKDEHMTAALMLLNQARQPEFIVDLPNQMGQASIQLQKSNASFHAAEKNGK LSMTIEIRAKGIIMENQSTYETRENDQYYIIQKALNRTIKKDVISTVHRLQKLKADPA GFQDRTIRSTATTKNLLKKEWEEVYKDMEVHVVPIVTIEQGGVLYKTISH*" /label="yfkR CDS" gene complement(797075..798229) /gene="yfkR" /locus_tag="BSU_07780" /old_locus_tag="BSU07780" /label="yfkR gene" CDS complement(798210..799751) /gene="yfkQ" /locus_tag="BSU_07790" /old_locus_tag="BSU07790" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10762253, 23625846; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative spore germination protein" /protein_id="NP_388660.1" /db_xref="EnsemblGenomes-Gn:BSU07790" /db_xref="EnsemblGenomes-Tr:CAB12608" /db_xref="GOA:O34486" /db_xref="InterPro:IPR004995" /db_xref="SubtiList:BG12932" /db_xref="UniProtKB/Swiss-Prot:O34486" /translation="MNKRDKALQLIKELEDNQDRPISPNLKENLENLTLLTEGCSDIV FRQFDFGNGLCGFIVYIEGIVKSEHIQDHALRPFLMHLTDQIDEHEEALQNTLSISSV ALETSMSKVAASIIEGNAVLFADGHSKGLILNIKGGQRRSIEEPITESTIRGSREGFT ESLRVNTALVRFRVKTFQLKMISFKIGTKTKTDVVLAYIDGLADPKVIDKAKKRIKKI KIDAVLESGYIEEFIEDDTYSPFPQLQYTERPDTVAAQLLEGRFAIFTDNTPFVLTGP ITFWQLMQASEDYYERYLMSNLIRWLRYMFLFVALYLPAIYVAVITYHQDLMPTNLMF SVASAREPIPFPAIIEALIMEISFEALREAGVRLPKTIGQTVSILGALVIGTAAVEAG IVSAPMVIIVSLTGIASFTIPRFNLAISIRMLRFPLMFLASIFGIFGIMLGTIILVLH LCKLQSFGIPYLSGISPFKRDEVKDIFVRAPWWTMTRRPGTYSRGNGQKGAKREDPKD EENNI*" /label="yfkQ CDS" gene complement(798210..799751) /gene="yfkQ" /locus_tag="BSU_07790" /old_locus_tag="BSU07790" /label="yfkQ gene" promotor_-10 complement(799801..799812) /Source="Nicolas_upshift_promotors" /id="U594" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=879 /SigmaFactorBS="aacacttttttatagcgctttcatcctagtctGGAATATatg aaacagacaaGGTTACCCTAAAagtcacaagcacttattgaatatgacattaaaaagc a" /listShort="yfkQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(799804) /Source="Nicolas_upshifts" /id="U594" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=879 /SigmaFactorBS="aacacttttttatagcgctttcatcctagtctGGAATATatg aaacagacaaGGTTACCCTAAAagtcacaagcacttattgaatatgacattaaaaagc a" /listShort="yfkQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(799826..799832) /Source="Nicolas_upshift_promotors" /id="U594" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=879 /SigmaFactorBS="aacacttttttatagcgctttcatcctagtctGGAATATatg aaacagacaaGGTTACCCTAAAagtcacaagcacttattgaatatgacattaaaaagc a" /listShort="yfkQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 799861..799868 /Source="Nicolas_upshift_promotors" /id="U595" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=1569 /SigmaFactorBS="tccagactaggatgaaagcgctataaaaaagTGTTGACTacc tgtatatacagGAATACAATATGATTATAAGttgtatatacaagttataaaaacggat a" /listShort="treP, treA, treR, yfkO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 799883..799902 /Source="Nicolas_upshift_promotors" /id="U595" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=1569 /SigmaFactorBS="tccagactaggatgaaagcgctataaaaaagTGTTGACTacc tgtatatacagGAATACAATATGATTATAAGttgtatatacaagttataaaaacggat a" /listShort="treP, treA, treR, yfkO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 799890 /Source="Nicolas_upshifts" /id="U595" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=1569 /SigmaFactorBS="tccagactaggatgaaagcgctataaaaaagTGTTGACTacc tgtatatacagGAATACAATATGATTATAAGttgtatatacaagttataaaaacggat a" /listShort="treP, treA, treR, yfkO" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(799936) /Source="Nicolas_upshifts" /id="D386" /incds=0 /nref=1 /ntot=29 /MaxReadThrough="1.35091" /MaxDrop="3.57201" /score="22.8661179" /energy="-15.2" /TU="NA" /idTUdmin="U596" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 799944..801356 /gene="treP" /locus_tag="BSU_07800" /old_locus_tag="BSU07800" /EC_number="2.7.1.201" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 8755887, 8917076, 8969503, 18977770" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 8755887, 8917076, 8969503, 18977770; Product type t : transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) trehalose-specific enzyme IIBC component" /protein_id="NP_388661.1" /db_xref="EnsemblGenomes-Gn:BSU07800" /db_xref="EnsemblGenomes-Tr:CAB12609" /db_xref="GOA:P39794" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR004719" /db_xref="InterPro:IPR011296" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="SubtiList:BG11009" /db_xref="UniProtKB/Swiss-Prot:P39794" /translation="MGELNKSARQIVEAVGGAENIAAATHCVTRLRFALIDESKVDQE MLDQIDVVKGSFSTNGQFQVVIGQGTVNKVYAELVKETGIGESTKDEVKKASEKNMNP LQRAVKTLADIFIPILPAIVTAGLLMGINNILTAEGIFFSTKSIVQVYPQWADLANMI NLIAGTAFTFLPALIGWSAVKRFGGNPLLGIVLGVMLVHPDLLNAWGYGAAEQSGEIP VWNLFGLEVQKVGYQGQVLPILLASYMLAKIEVFLTKRTPEGIQLLVVAPITLLLTGF ASFIIIGPITFAIGNVLTSGLISVFGSFAALGGLLYGGFYSALVITGMHHTFLAVDLQ LIGSKLGGTFLWPMLALSNIAQGSAALAMMFIVKDEKQKGLSLTSGISAYLGITEPAI FGVNLRYRFPFIIAMVSSGLAGMYISSQGVLASSVGVGGVPGIFSIMSQYWGAFAIGM AIVLIVPFAGTYAYARFKHK*" /label="treP CDS" gene 799944..801356 /gene="treP" /locus_tag="BSU_07800" /old_locus_tag="BSU07800" /label="treP gene" promotor_no_box complement(799962..800062) /Source="Nicolas_upshift_promotors" /id="U596" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.66033966033966" /psig="0.0889110889110889" /xcortree=1570 /SigmaFactorBS="ttgctttcatctattaaagcaaaacgcaaacgtgtaacacaa tgagttgccgctgcaatattttcagcaccgccgactgcttcgacaatctgacgtgccg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(800002) /Source="Nicolas_upshifts" /id="U596" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.66033966033966" /psig="0.0889110889110889" /xcortree=1570 /SigmaFactorBS="ttgctttcatctattaaagcaaaacgcaaacgtgtaacacaa tgagttgccgctgcaatattttcagcaccgccgactgcttcgacaatctgacgtgccg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 801427..803112 /gene="treA" /locus_tag="BSU_07810" /old_locus_tag="BSU07810" /EC_number="3.2.1.93" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7651129, 7751281, 8755887, 8917076, 9701821, 26894535" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7651129, 7751281, 8755887, 8917076, 9701821, 26894535; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="trehalose-6-phosphate hydrolase" /protein_id="NP_388662.1" /db_xref="EnsemblGenomes-Gn:BSU07810" /db_xref="EnsemblGenomes-Tr:CAB12610" /db_xref="GOA:P39795" /db_xref="InterPro:IPR006047" /db_xref="InterPro:IPR012769" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR032091" /db_xref="SubtiList:BG11010" /db_xref="UniProtKB/Swiss-Prot:P39795" /translation="MKTEQTPWWKKAVVYQIYPKSFNDTTGNGVGDLNGIIEKLDYLK TLQVDVLWLTPIYDSPQHDNGYDIRDYYSIYPEYGTMEDFERLVSEAHKRDLKVVMDL VVNHTSTEHKWFREAISSIDSPYRDFYIWKKPQENGSVPTNWESKFGGSAWELDEASG QYYLHLFDVTQADLNWENEEVRKHVYDMMHFWFEKGIDGFRLDVINLISKDQRFPNAE EGDGRSFYTDGPRVHEFLHEMNEKVFSHYDSMTVGEMSSTTVDHCIRYTNPDNKELDM TFSFHHLKVDYPNGEKWALAPFDFLKLKEILSDWQTGMHAGGGWNALFWCNHDQPRVV SRYGDDGAYRVKSAKMLATAIHMMQGTPYIYQGEELGMTNPKFTDISSYRDVESLNMY HAFKEKGMADQDITAILQAKSRDNSRTPVQWDATENGGFTTGTPWIPVAGNYREINAE AALRDQNSVFYHYQKLIQIRKMYDIVTEGTYEIIAKDDPNIFAYLRHGSNEKLLVINN FYGTEAAFTLPDSLAPDEWKAEVLLTNDEAREGLQNMTLRPYESIVYRLTKPC*" /label="treA CDS" gene 801427..803112 /gene="treA" /locus_tag="BSU_07810" /old_locus_tag="BSU07810" /label="treA gene" promotor_-10 complement(801733..801748) /Source="Nicolas_upshift_promotors" /id="U597" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1694 /SigmaFactorBS="tacgggctgtctattgaagagatcgcctcgCGAAACCATTtg tgctctgttgACGTATGATTGACAACaagatccatgacgactttcaggtctcttttat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(801740) /Source="Nicolas_upshifts" /id="U597" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1694 /SigmaFactorBS="tacgggctgtctattgaagagatcgcctcgCGAAACCATTtg tgctctgttgACGTATGATTGACAACaagatccatgacgactttcaggtctcttttat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(801761..801770) /Source="Nicolas_upshift_promotors" /id="U597" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1694 /SigmaFactorBS="tacgggctgtctattgaagagatcgcctcgCGAAACCATTtg tgctctgttgACGTATGATTGACAACaagatccatgacgactttcaggtctcttttat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 803085..803089 /Source="Nicolas_upshift_promotors" /id="U598" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2516 /SigmaFactorBS="ggcttcagaacatgacgcttcgcccatatgagtccatTGTTT atcgtttaacgaaacCGTGTTAAACTAAGCTGGGTggtccataatgaaggtgaataaa t" /listShort="treR, yfkO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 803105..803124 /Source="Nicolas_upshift_promotors" /id="U598" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2516 /SigmaFactorBS="ggcttcagaacatgacgcttcgcccatatgagtccatTGTTT atcgtttaacgaaacCGTGTTAAACTAAGCTGGGTggtccataatgaaggtgaataaa t" /listShort="treR, yfkO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 803108 /Source="Nicolas_upshifts" /id="U598" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2516 /SigmaFactorBS="ggcttcagaacatgacgcttcgcccatatgagtccatTGTTT atcgtttaacgaaacCGTGTTAAACTAAGCTGGGTggtccataatgaaggtgaataaa t" /listShort="treR, yfkO" /GFF_Attribute="listLong" /label="upshifts" CDS 803133..803849 /gene="treR" /locus_tag="BSU_07820" /old_locus_tag="BSU07820" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8755887, 9829827, 17705272" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8755887, 9829827, 17705272; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (TreR-trehalose)" /protein_id="NP_388663.1" /db_xref="EnsemblGenomes-Gn:BSU07820" /db_xref="EnsemblGenomes-Tr:CAB12611" /db_xref="GOA:P39796" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR011663" /db_xref="InterPro:IPR012770" /db_xref="InterPro:IPR028978" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2OGG" /db_xref="SubtiList:BG11011" /db_xref="UniProtKB/Swiss-Prot:P39796" /translation="MKVNKFITIYKDIAQQIEGGRWKAEEILPSEHELTAQYGTSRET VRKALHMLAQNGYIQKIRGKGSVVLNREKMQFPVSGLVSFKELAQTLGKETKTTVHKF GLEPPSELIQKQLRANLDDDIWEVIRSRKIDGEHVILDKDYFFRKHVPHLTKEICENS IYEYIEGELGLSISYAQKEIVAEPCTDEDRELLDLRGYDHMVVVRNYVFLEDTSLFQY TESRHRLDKFRFVDFARRGK*" /label="treR CDS" gene 803133..803849 /gene="treR" /locus_tag="BSU_07820" /old_locus_tag="BSU07820" /label="treR gene" downshifts 803842 /Source="Nicolas_upshifts" /id="D387" /incds=0 /nref=3 /ntot=115 /MaxReadThrough="6.58905" /MaxDrop="4.05981" /score="24.6748216" /energy="-11.1" /TU="U595,U598" /idTUdmin="U595" /TUdmin="-792" /isTUend="FALSE" /label="downshifts" promotor_-35 803924..803927 /Source="Nicolas_upshift_promotors" /id="U599" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.432567432567433" /psig="0.995004995004995" /xcortree=611 /SigmaFactorBS="caaaattgatactatccaacaaaaatgtgcgtACTTttactt tttatcataATGGCTACAATAGAGATGAGagtaatctaaaggagaggtgttttacatg g" /listShort="yfkO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 803943..803962 /Source="Nicolas_upshift_promotors" /id="U599" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.432567432567433" /psig="0.995004995004995" /xcortree=611 /SigmaFactorBS="caaaattgatactatccaacaaaaatgtgcgtACTTttactt tttatcataATGGCTACAATAGAGATGAGagtaatctaaaggagaggtgttttacatg g" /listShort="yfkO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 803952 /Source="Nicolas_upshifts" /id="U599" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.432567432567433" /psig="0.995004995004995" /xcortree=611 /SigmaFactorBS="caaaattgatactatccaacaaaaatgtgcgtACTTttactt tttatcataATGGCTACAATAGAGATGAGagtaatctaaaggagaggtgttttacatg g" /listShort="yfkO" /GFF_Attribute="listLong" /label="upshifts" CDS 803989..804654 /gene="hypO" /locus_tag="BSU_07830" /old_locus_tag="BSU07830" /EC_number="1.5.1.39" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15252706, 20727918, 20862523, 22238377, 26415543" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15252706, 20727918, 20862523, 22238377, 26415543; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NAD(P)H-flavin oxidoreductase (nitroreductase)" /protein_id="NP_388664.1" /db_xref="EnsemblGenomes-Gn:BSU07830" /db_xref="EnsemblGenomes-Tr:CAB12612" /db_xref="GOA:O34475" /db_xref="InterPro:IPR000415" /db_xref="InterPro:IPR029479" /db_xref="InterPro:IPR033878" /db_xref="SubtiList:BG12931" /db_xref="UniProtKB/Swiss-Prot:O34475" /translation="MADLKTQILDAYNFRHATKEFDPNKKVSDSDFEFILETGRLSPS SLGLEPWKFVVVQNPEFREKLREYTWGAQKQLPTASHFVLILARTAKDIKYNADYIKR HLKEVKQMPQDVYEGYLSKTEEFQKNDLHLLESDRTLFDWASKQTYIALGNMMTAAAQ IGVDSCPIEGFQYDHIHRILEEEGLLENGSFDISVMVAFGYRVRDPRPKTRSAVEDVV KWV*" /label="hypO CDS" gene 803989..804654 /gene="hypO" /locus_tag="BSU_07830" /old_locus_tag="BSU07830" /label="hypO gene" downshifts 804635 /Source="Nicolas_upshifts" /id="D388" /incds=0 /nref=180 /ntot=269 /MaxReadThrough="0.70079" /MaxDrop="6.77615" /score="34.5750428" /energy="-16.9" /TU="NA" /idTUdmin="U595" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(804691..809079) /gene="yfkN" /locus_tag="BSU_07840" /old_locus_tag="BSU07840" /EC_number="3.1.4.16" /EC_number="3.1.3.5" /EC_number="3.1.3.6" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14688230, 16291680, 21800427, 21906378, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exported 2',3'-cyclic-nucleotide 2'-phosphodiesterase, 2' (or 3') nucleotidase and 5' nucleotidase" /protein_id="NP_388665.1" /db_xref="EnsemblGenomes-Gn:BSU07840" /db_xref="EnsemblGenomes-Tr:CAB12613" /db_xref="GOA:O34313" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR006146" /db_xref="InterPro:IPR006179" /db_xref="InterPro:IPR008334" /db_xref="InterPro:IPR029052" /db_xref="InterPro:IPR036907" /db_xref="PDB:3GVE" /db_xref="SubtiList:BG12930" /db_xref="UniProtKB/Swiss-Prot:O34313" /translation="MRIQKRRTHVENILRILLPPIMILSLILPTPPIHAEESAAPQVH LSILATTDIHANMMDYDYYSDKETADFGLARTAQLIQKHREQNPNTLLVDNGDLIQGN PLGEYAVKYQKDDIISGTKTHPIISVMNALKYDAGTLGNHEFNYGLDFLDGTIKGADF PIVNANVKTTSGENRYTPYVINEKTLIDENGNEQKVKVGYIGFVPPQIMTWDKKNLEG QVQVQDIVESANETIPKMKAEGADVIIALAHTGIEKQAQSSGAENAVFDLATKTKGID AIISGHQHGLFPSAEYAGVAQFNVEKGTINGIPVVMPSSWGKYLGVIDLKLEKADGSW KVADSKGSIESIAGNVTSRNETVTNTIQQTHQNTLEYVRKPVGKTEADINSFFAQVKD DPSIQIVTDAQKWYAEKEMKDTEYKNLPILSAGAPFKAGGRNGANYYTNIPAGDLAIK NVGDLYLYDNTVQIVKLTGSEVKDWLEMSAGQFNQIDPAKGGDQALLNENFRSYNFDV IDGVTYQVDVTKPAKYNENGKVINADSSRIINLSYEGKPISPSQEFLVVTNNYRASGG GGFPHLTSDKIVHGSAVENRQVLMDYIIEQKTVNPKADNNWSIAPVSGTNLTFESSLL AKPFADKADDVAYVGKSANEGYGVYKLQFDDDSNPDPPKDGLWDLTVMHTNDTHAHLD DAARRMTKINEVRSETNHNILLDAGDVFSGDLYFTKWNGLADLKMMNMMGYDAMTFGN HEFDKGPTVLSDFLSGNSATVDPANRYHFEAPEFPIVSANVDVSNEPKLKSFVKKPQT FTAGEKKEAGIHPYILLDVDGEKVAVFGLTTEDTATTSSPGKSIVFNDAFETAQNTVK AIQEEEKVNKIIALTHIGHNRDLELAKKVKGIDLIIGGHTHTLVDKMEVVNNEEPTIV AQAKEYGQFLGRVDVAFDEKGVVQTDKSNLSVLPIDEHTEENPEAKQELDQFKNELED VKNEKVGYTDVALDGQREHVRTKETNLGNFIADGMLAKAKEAAGARIAITNGGGIRAG IDKGDITLGEVLNVMPFGNTLYVADLTGKQIKEALEQGLSNVENGGGAFPQVAGIEYT FTLNNKPGHRVLEVKIESPNGDKVAINTDDTYRVATNNFVGAGGDGYSVFTEASHGED LGYVDYEIFTEQLKKLGNKVSPKVEGRIKEVFLPTKQKDGSWTLDEDKFAIYAKNANT PFVYYGIHEGSQEKPINLKVKKDQVKLLKERESDPSLTMFNYWYSMKMPMANLKTADT AIGIKSTGELDVSLSDVYDFTVKQKGKEIKSFKEPVQLSLRMFDIEEAHNPAIYHVDR KKKAFTKTGHGSVDDDMVTGYTNHFSEYTILNSGSNNKPPAFPSDQPTGGDDGNHGGG SDKPGGKQPTDGNGGNDTPPGTQPTNGSGGNGSGGSGTDGPAGGLLPDTATSMYSILL AGFLISALGTAMYLHQRRKQNRANQA*" /label="yfkN CDS" gene complement(804691..809079) /gene="yfkN" /locus_tag="BSU_07840" /old_locus_tag="BSU07840" /label="yfkN gene" downshifts complement(804710) /Source="Nicolas_upshifts" /id="D389" /incds=0 /nref=155 /ntot=229 /MaxReadThrough="1.00159" /MaxDrop="7.08591" /score="22.8661179" /energy="-15.2" /TU="NA" /idTUdmin="U600" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(809112..809131) /Source="Nicolas_upshift_promotors" /id="U600" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.944055944055944" /psig="0.994005994005994" /xcortree=462 /SigmaFactorBS="actcatttttctcccttttacaataatcataaagaaacacCT ACaaatagttacaaaaTATTCTTACAATAGGAGCTGtaacacaaatttcgttgaaagg t" /listShort="yfkN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(809129) /Source="Nicolas_upshifts" /id="U600" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.944055944055944" /psig="0.994005994005994" /xcortree=462 /SigmaFactorBS="actcatttttctcccttttacaataatcataaagaaacacCT ACaaatagttacaaaaTATTCTTACAATAGGAGCTGtaacacaaatttcgttgaaagg t" /listShort="yfkN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(809146..809149) /Source="Nicolas_upshift_promotors" /id="U600" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.944055944055944" /psig="0.994005994005994" /xcortree=462 /SigmaFactorBS="actcatttttctcccttttacaataatcataaagaaacacCT ACaaatagttacaaaaTATTCTTACAATAGGAGCTGtaacacaaatttcgttgaaagg t" /listShort="yfkN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 809256..809262 /Source="Nicolas_upshift_promotors" /id="U601" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=231 /SigmaFactorBS="tgggcatttatgcttatcgtttgtcacaatcgcggaaTGTTT ATtttagtgtggctgGGGTAGAGTGTTTTATGTAgacatataaagcgggaggttatga a" /listShort="yfkM, S273, yfkJ, yfkI, yfkH, S275" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 809276..809294 /Source="Nicolas_upshift_promotors" /id="U601" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=231 /SigmaFactorBS="tgggcatttatgcttatcgtttgtcacaatcgcggaaTGTTT ATtttagtgtggctgGGGTAGAGTGTTTTATGTAgacatataaagcgggaggttatga a" /listShort="yfkM, S273, yfkJ, yfkI, yfkH, S275" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 809279 /Source="Nicolas_upshifts" /id="U601" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=231 /SigmaFactorBS="tgggcatttatgcttatcgtttgtcacaatcgcggaaTGTTT ATtttagtgtggctgGGGTAGAGTGTTTTATGTAgacatataaagcgggaggttatga a" /listShort="yfkM, S273, yfkJ, yfkI, yfkH, S275" /GFF_Attribute="listLong" /label="upshifts" CDS 809322..809840 /gene="sufLB" /locus_tag="BSU_07850" /old_locus_tag="BSU07850" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10220166, 12354229, 16181642, 17257049, 17933887, 24330391, 25283443, 25561404" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10220166, 12354229, 16181642, 17257049, 17933887, 24330391, 25283443, 25561404; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="general stress protein 18; deglycase" /protein_id="NP_388666.1" /db_xref="EnsemblGenomes-Gn:BSU07850" /db_xref="EnsemblGenomes-Tr:CAB12614" /db_xref="GOA:P80876" /db_xref="InterPro:IPR002818" /db_xref="InterPro:IPR006286" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG12929" /db_xref="UniProtKB/Swiss-Prot:P80876" /translation="MGKKIAVVLTYYFEDSEYTEPAKAFKEAGHELTVIEKEKGKTVK GKQGTAEVTVDASIDDVNSSDFDALLIPGGFSPDQLRADDRFVQFTKAFMTDKKPVFA ICHGPQLLINAKALDGRKATGYTSIRVDMENAGADVVDKEVVVCQDQLVTSRTPDDIP AFNRESLALLEK*" /label="sufLB CDS" gene 809322..809840 /gene="sufLB" /locus_tag="BSU_07850" /old_locus_tag="BSU07850" /label="sufLB gene" downshifts 809826 /Source="Nicolas_upshifts" /id="D390" /incds=0 /nref=35 /ntot=153 /MaxReadThrough="8.02255" /MaxDrop="6.97573" /score="42.2080398" /energy="-12.9" /TU="U601" /idTUdmin="U601" /TUdmin="-3542" /isTUend="FALSE" /label="downshifts" downshifts complement(809870) /Source="Nicolas_upshifts" /id="D391" /incds=0 /nref=22 /ntot=199 /MaxReadThrough="1.59285" /MaxDrop="3.61098" /score="31.1923457" /energy="-11.1" /TU="NA" /idTUdmin="U602" /TUdmin=10 /isTUend="TRUE" /label="downshifts" S_feature 809871..811521 /Source="Nicolas_S_feature" /locus_tag="new_860294_861944" /HighExp="Etha, S6, S8, S5, S7, Gly, Salt, LoTm, S4, Diami" /AntisenseName="yfkL" /AntisenseCor="-0.52109661167911703" /AntisenseRegPval="-19.399999999999999" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S273" CDS complement(809880..811070) /gene="yfkL" /locus_tag="BSU_07860" /old_locus_tag="BSU07860" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16828913, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="efflux transporter" /protein_id="NP_388667.1" /db_xref="EnsemblGenomes-Gn:BSU07860" /db_xref="EnsemblGenomes-Tr:CAB12615" /db_xref="GOA:O34597" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12928" /db_xref="UniProtKB/Swiss-Prot:O34597" /translation="MQTTSIKTASGMYINYFFLGMVNIILASNMSSLTKQWNTDPTGI SYVIAAIGFGKLLTYGISGVLSDKIGRKPLVVASAGIMAVFLVGIPLSPSYELAFVFA LLAGVANSAMDAGTYPALTELFPSASGSANVLVKAFMSVGAALLPLLITFLADHSMFY GFAFYLPAAVYLLNIIYLSTLSFPKKHKKPTNSGQQESPVFLSEPVFQKEGTALIIIG FTSTALFTVSQIWLPSYAQKAAGLAESASVQLLSYYSIGSLASVLLLAVLLNRWVKPV FITLLYPIITLCTLAVMLTVHIPVVLDITAFFLGFSTAGVFQITITLMTELFWKRKGT VTGIVATASSLASILLPIATGLIAKAGGIAHIFIFDFGIAVIGTAAAAFLYYRYKKLT GAQA*" /label="yfkL CDS" gene complement(809880..811070) /gene="yfkL" /locus_tag="BSU_07860" /old_locus_tag="BSU07860" /label="yfkL gene" S_feature complement(811071..811162) /Source="Nicolas_S_feature" /locus_tag="new_861494_861585_c" /HighExp="C90, MG 10, BMM, MG-0.2, MG t5, MG 5, MG-0.1, UNK1, HPh, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S274" CDS complement(811163..811378) /gene="yfkK" /locus_tag="BSU_07870" /old_locus_tag="BSU07870" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388668.1" /db_xref="EnsemblGenomes-Gn:BSU07870" /db_xref="EnsemblGenomes-Tr:CAB12616" /db_xref="InterPro:IPR009507" /db_xref="SubtiList:BG12927" /db_xref="UniProtKB/Swiss-Prot:O35019" /translation="MSSPNTETLTQMIEEISQKLNMLNVGVIKAEDFSDEKIEDLTYL HRMVMKKESFSPSEMQAIAQELASLRK*" /label="yfkK CDS" gene complement(811163..811378) /gene="yfkK" /locus_tag="BSU_07870" /old_locus_tag="BSU07870" /label="yfkK gene" downshifts complement(811222) /Source="Nicolas_upshifts" /id="D392" /incds=0 /nref=1 /ntot=131 /MaxReadThrough="3.65318" /MaxDrop="2.45155" /score="16.183887" /energy="-11.6" /TU="U602" /idTUdmin="U602" /TUdmin="-1342" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(811410..811429) /Source="Nicolas_upshift_promotors" /id="U602" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.593406593406593" /psig="0.994005994005994" /xcortree=3074 /SigmaFactorBS="tcacttttttggaatgaacagcctgcttttagaatagggTTt ttttctgatggaaTTCTGTTAGAATAAAACATAcctatattgcgcatagaaaggatgg a" /listShort="yfkK, S274, yfkL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(811424) /Source="Nicolas_upshifts" /id="U602" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.593406593406593" /psig="0.994005994005994" /xcortree=3074 /SigmaFactorBS="tcacttttttggaatgaacagcctgcttttagaatagggTTt ttttctgatggaaTTCTGTTAGAATAAAACATAcctatattgcgcatagaaaggatgg a" /listShort="yfkK, S274, yfkL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(811444..811445) /Source="Nicolas_upshift_promotors" /id="U602" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.593406593406593" /psig="0.994005994005994" /xcortree=3074 /SigmaFactorBS="tcacttttttggaatgaacagcctgcttttagaatagggTTt ttttctgatggaaTTCTGTTAGAATAAAACATAcctatattgcgcatagaaaggatgg a" /listShort="yfkK, S274, yfkL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 811491..811498 /Source="Nicolas_upshift_promotors" /id="U603" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.82017982017982" /psig="0.994005994005994" /xcortree=134 /SigmaFactorBS="gctgttcattccaaaaaagtgaagacatCAGTTGAAaagaaa atgaacatCCTACTAAGATATTCATGAAggtttctttttagagaaataggggcaaaga a" /listShort="yfkJ, yfkI, yfkH, S275" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 811513..811532 /Source="Nicolas_upshift_promotors" /id="U603" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.82017982017982" /psig="0.994005994005994" /xcortree=134 /SigmaFactorBS="gctgttcattccaaaaaagtgaagacatCAGTTGAAaagaaa atgaacatCCTACTAAGATATTCATGAAggtttctttttagagaaataggggcaaaga a" /listShort="yfkJ, yfkI, yfkH, S275" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 811523 /Source="Nicolas_upshifts" /id="U603" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.82017982017982" /psig="0.994005994005994" /xcortree=134 /SigmaFactorBS="gctgttcattccaaaaaagtgaagacatCAGTTGAAaagaaa atgaacatCCTACTAAGATATTCATGAAggtttctttttagagaaataggggcaaaga a" /listShort="yfkJ, yfkI, yfkH, S275" /GFF_Attribute="listLong" /label="upshifts" CDS 811581..812051 /gene="yfkJ" /locus_tag="BSU_07880" /old_locus_tag="BSU07880" /EC_number="3.1.3.48" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15995210" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15995210; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein-tyrosine-phosphatase" /protein_id="NP_388669.1" /db_xref="EnsemblGenomes-Gn:BSU07880" /db_xref="EnsemblGenomes-Tr:CAB12617" /db_xref="GOA:O35016" /db_xref="InterPro:IPR017867" /db_xref="InterPro:IPR023485" /db_xref="InterPro:IPR036196" /db_xref="PDB:4ETM" /db_xref="SubtiList:BG12926" /db_xref="UniProtKB/Swiss-Prot:O35016" /translation="MISVLFVCLGNICRSPMAEAIFRDLAAKKGLEGKIKADSAGIGG WHIGNPPHEGTQEILRREGISFDGMLARQVSEQDLDDFDYIIAMDAENIGSLRSMAGF KNTSHIKRLLDYVEDSDLADVPDPYYTGNFEEVCQLIKTGCEQLLASIQKEKQL*" /label="yfkJ CDS" gene 811581..812051 /gene="yfkJ" /locus_tag="BSU_07880" /old_locus_tag="BSU07880" /label="yfkJ gene" CDS 812069..812389 /gene="yfkI" /locus_tag="BSU_07890" /old_locus_tag="BSU07890" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15995210" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388670.1" /db_xref="EnsemblGenomes-Gn:BSU07890" /db_xref="EnsemblGenomes-Tr:CAB12618" /db_xref="SubtiList:BG12925" /db_xref="UniProtKB/Swiss-Prot:O34418" /translation="MNNERLMLKGIFLGAAAGAALSLLHKPTRQACGMRWLTCKHKLS LYKSNPELLKNTVITKVDEAKKLARTLSKEVDFVNQQVKELKKTTPQVMELVQETKEH FSKK*" /label="yfkI CDS" gene 812069..812389 /gene="yfkI" /locus_tag="BSU_07890" /old_locus_tag="BSU07890" /label="yfkI gene" CDS 812413..813240 /gene="rbn" /locus_tag="BSU_07900" /old_locus_tag="BSU07900" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11222749, 12794188, 15849754, 16850406, 15764599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ribonuclease BN" /protein_id="NP_388671.1" /db_xref="EnsemblGenomes-Gn:BSU07900" /db_xref="EnsemblGenomes-Tr:CAB12619" /db_xref="GOA:O34437" /db_xref="InterPro:IPR017039" /db_xref="SubtiList:BG12924" /db_xref="UniProtKB/Swiss-Prot:O34437" /translation="MSFLKELFSRYTLHEGQSKSAELAYFFLLSLFPFLIFMLTLTAY LPLSTDDVLGVIEQYAPASAMSLVESITHQTLNNRNGGLLSFGIIAALWSASNGMNAI VRSLNHAYDVEENRSFIIVRLTSIFLTIAMVFTILVALLLPVFGREIGRLASDFVGAS DLFLSVWAAIRWGVSPLVLLIVFSALYVIAPNKKLSLRFVMPGAVFATIGWIIVSTLF SFYVSTFANYSATYGSIGGIIVLMIWFYLSGILIILGGEINALLHKRKKLPDENPYH* " /label="rbn CDS" gene 812413..813240 /gene="rbn" /locus_tag="BSU_07900" /old_locus_tag="BSU07900" /label="rbn gene" promotor_-35 813219..813225 /Source="Nicolas_upshift_promotors" /id="U604" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=847 /SigmaFactorBS="acataaacgtaaaaagcttccTGATGAAaatccctaccatta GCGCACCCTATAaacgaacttcggttcaaaaagaagtcggggggatatcgtgatgacc a" /listShort="S275" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 813240..813251 /Source="Nicolas_upshift_promotors" /id="U604" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=847 /SigmaFactorBS="acataaacgtaaaaagcttccTGATGAAaatccctaccatta GCGCACCCTATAaacgaacttcggttcaaaaagaagtcggggggatatcgtgatgacc a" /listShort="S275" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 813258..813414 /Source="Nicolas_S_feature" /locus_tag="new_863681_863837" /HighExp="S8, Etha, S6, Salt, S7, S5, ferm, nit, BT, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99976299999999996" /TUshortSig="SigGF, SigA, SigB" /TUshortPSig="0.974, 0.994, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S275" upshifts 813258 /Source="Nicolas_upshifts" /id="U604" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=847 /SigmaFactorBS="acataaacgtaaaaagcttccTGATGAAaatccctaccatta GCGCACCCTATAaacgaacttcggttcaaaaagaagtcggggggatatcgtgatgacc a" /listShort="S275" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(813290) /Source="Nicolas_upshifts" /id="D393" /incds=0 /nref=1 /ntot=4 /MaxReadThrough="1.22239" /MaxDrop="3.61507" /score="-5.45682213" /energy="-3" /TU="NA" /idTUdmin="U606" /TUdmin=440 /isTUend="FALSE" /label="downshifts" downshifts 813389 /Source="Nicolas_upshifts" /id="D394" /incds=0 /nref=144 /ntot=253 /MaxReadThrough="1.4253" /MaxDrop="6.85849" /score="25.8200126" /energy="-17.9" /TU="NA" /idTUdmin="U603" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(813439..814614) /gene="yfkF" /locus_tag="BSU_07910" /old_locus_tag="BSU07910" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388672.1" /db_xref="EnsemblGenomes-Gn:BSU07910" /db_xref="EnsemblGenomes-Tr:CAB12620" /db_xref="GOA:O34929" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12923" /db_xref="UniProtKB/Swiss-Prot:O34929" /translation="MSRFHFFILVLLVSISGFSQGMLLPVISIIFETNGESAAINGLH ATGLYIGVLLASPFMEAPLRKLGFKPLIVMGGSIVILSLFGFIWLQSVWVWFLLRLFI GIGDHMLHFSTQTWVTSMSSKQNRGRNLSIYGLSFGLGFAAGPFMVPLVKLSPSLPFI VSGCISLFAWLFVFFLQNAYPETSPHETKSDNSFRRFYQAMLFGWVAFMPTFGYGFLE TALNGSFPVYALRLGISVDAVAIILPAFAIGSIIFQFPLGILSDKYGRRNVLLVILLT GALCFFIAGVFPSPYVIGGCFFIAGMAVGSTFTLGISYMTDLLPPHLLPAGNLLCGIT FSLGSILGPVAGGWYMQTFESANLFYFITLTLSSVWLALVLGKPKSWSPAETYSSSS* " /label="yfkF CDS" gene complement(813439..814614) /gene="yfkF" /locus_tag="BSU_07910" /old_locus_tag="BSU07910" /label="yfkF gene" downshifts complement(813444) /Source="Nicolas_upshifts" /id="D395" /incds=0 /nref=1 /ntot=97 /MaxReadThrough="0.37084" /MaxDrop="3.28031" /score="3.2266059" /energy="-14.1" /TU="NA" /idTUdmin="U606" /TUdmin=286 /isTUend="FALSE" /label="downshifts" promotor_-35 814051..814057 /Source="Nicolas_upshift_promotors" /id="U605" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=204 /SigmaFactorBS="cctgataaaatcgcctgaaactattgtctgatttGGTTTCAt gaggactggtttccGGGTATGCATTTTGTAGAAagaaaacaaaaagccacgcaaacag a" /listShort="S276, yfkE, yfkD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 814073..814091 /Source="Nicolas_upshift_promotors" /id="U605" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=204 /SigmaFactorBS="cctgataaaatcgcctgaaactattgtctgatttGGTTTCAt gaggactggtttccGGGTATGCATTTTGTAGAAagaaaacaaaaagccacgcaaacag a" /listShort="S276, yfkE, yfkD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 814077..814730 /Source="Nicolas_S_feature" /locus_tag="new_864500_865153" /HighExp="Etha, M9-stat, Salt, Sw, Gly, B60, Heat, LPhT, HiTm, T0.30H" /AntisenseName="yfkF" /AntisenseCor="-0.18505347560608301" /AntisenseRegPval="-2.6" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S276" upshifts 814077 /Source="Nicolas_upshifts" /id="U605" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=204 /SigmaFactorBS="cctgataaaatcgcctgaaactattgtctgatttGGTTTCAt gaggactggtttccGGGTATGCATTTTGTAGAAagaaaacaaaaagccacgcaaacag a" /listShort="S276, yfkE, yfkD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(814639..814658) /Source="Nicolas_upshift_promotors" /id="U606" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig=1 /xcortree=3138 /SigmaFactorBS="gagggcaaatgtatagcgtgatataggcttttttcAGGTTGC CtgcttttggaaaaCGTTGTACGATCAACATAGAttccatataaggagaactgacacg a" /listShort="yfkF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(814654) /Source="Nicolas_upshifts" /id="U606" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig=1 /xcortree=3138 /SigmaFactorBS="gagggcaaatgtatagcgtgatataggcttttttcAGGTTGC CtgcttttggaaaaCGTTGTACGATCAACATAGAttccatataaggagaactgacacg a" /listShort="yfkF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(814672..814679) /Source="Nicolas_upshift_promotors" /id="U606" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig=1 /xcortree=3138 /SigmaFactorBS="gagggcaaatgtatagcgtgatataggcttttttcAGGTTGC CtgcttttggaaaaCGTTGTACGATCAACATAGAttccatataaggagaactgacacg a" /listShort="yfkF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 814720..814725 /Source="Nicolas_upshift_promotors" /id="U607" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.848151848151848" /psig="0.848151848151848" /xcortree=1179 /SigmaFactorBS="ggcaacctgaaaaaagcctatatcacgctatacatttgccct cgtgtaATCATGaaggtttttgtgaaGAATAAAAATAAAACAAGTcataaaaaaggag c" /listShort="yfkE" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 814732 /Source="Nicolas_upshifts" /id="U607" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.848151848151848" /psig="0.848151848151848" /xcortree=1179 /SigmaFactorBS="ggcaacctgaaaaaagcctatatcacgctatacatttgccct cgtgtaATCATGaaggtttttgtgaaGAATAAAAATAAAACAAGTcataaaaaaggag c" /listShort="yfkE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 814740..814758 /Source="Nicolas_upshift_promotors" /id="U607" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.848151848151848" /psig="0.848151848151848" /xcortree=1179 /SigmaFactorBS="ggcaacctgaaaaaagcctatatcacgctatacatttgccct cgtgtaATCATGaaggtttttgtgaaGAATAAAAATAAAACAAGTcataaaaaaggag c" /listShort="yfkE" /GFF_Attribute="listLong" /label="promotor_-10" CDS 814782..815837 /gene="chaA" /locus_tag="BSU_07920" /old_locus_tag="BSU07920" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 19543710, 23798403" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 19543710, 23798403; Product type t: transporter" /codon_start=1 /transl_table=11 /product="H+/Ca2+ antiporter" /protein_id="NP_388673.1" /db_xref="EnsemblGenomes-Gn:BSU07920" /db_xref="EnsemblGenomes-Tr:CAB12621" /db_xref="GOA:O34840" /db_xref="InterPro:IPR004713" /db_xref="InterPro:IPR004798" /db_xref="InterPro:IPR004837" /db_xref="PDB:4KJR" /db_xref="PDB:4KJS" /db_xref="SubtiList:BG12922" /db_xref="UniProtKB/Swiss-Prot:O34840" /translation="MNRIFFILVAAGVPLSVIGSLMHWPSAVLFAVYCVTIIALASYM GRATESLSIIAGPRIGGLLNATFGNAVELIISLFALKEGLTGIVLASLTGSVLGNLLL VAGLSFFVGGLKYKRQEFNIHDARHNSGLLIFAIIVAFVIPEVFSVGMGNASKLNLSI GISIIMILLYVAALYFKLVTHRGVYQPNNAAQTEEEEEPEWSGKVATIVLFAATIVVA YISENLVHTFHSVAEQFGWSELFIGVIIVAIVGNAAEHASAIIMAFKNKMDIAVEIAV GSTLQIAMFVAPVLVICSIFFPTSMPLVFTLPELVAMVSAVLLMIAISNDGDSNWFEG ATLLAAYVIMAIGFFLL*" /label="chaA CDS" gene 814782..815837 /gene="chaA" /locus_tag="BSU_07920" /old_locus_tag="BSU07920" /label="chaA gene" promotor_-35 815851..815857 /Source="Nicolas_upshift_promotors" /id="U608" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=931 /SigmaFactorBS="gatcggctttttccttctttaacctgaaaaaatgaTGGATAA caacaaagcgggatGAAAAGACTAAGggaaaatgccatagaaagagtgatatgatgaa a" /listShort="yfkD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 815872..815883 /Source="Nicolas_upshift_promotors" /id="U608" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=931 /SigmaFactorBS="gatcggctttttccttctttaacctgaaaaaatgaTGGATAA caacaaagcgggatGAAAAGACTAAGggaaaatgccatagaaagagtgatatgatgaa a" /listShort="yfkD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 815876 /Source="Nicolas_upshifts" /id="U608" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=931 /SigmaFactorBS="gatcggctttttccttctttaacctgaaaaaatgaTGGATAA caacaaagcgggatGAAAAGACTAAGggaaaatgccatagaaagagtgatatgatgaa a" /listShort="yfkD" /GFF_Attribute="listLong" /label="upshifts" CDS 815908..816702 /gene="yfkD" /locus_tag="BSU_07930" /old_locus_tag="BSU07930" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 19543710" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388674.1" /db_xref="EnsemblGenomes-Gn:BSU07930" /db_xref="EnsemblGenomes-Tr:CAB12622" /db_xref="InterPro:IPR025548" /db_xref="SubtiList:BG12921" /db_xref="UniProtKB/Swiss-Prot:O34579" /translation="MMKKLFHSTLIVLLFFSFFGVQPIHAKKQFKVPNSVASISKENT YPNASQDQPMLQPSKLAKELLDHSEVKIENPHLIKMLNESNISGTPLAVGYRATIFLG KWALGYESNETVANWEYKKINTNRADNRGGKETAEMHYAQEQQYRVKGGLTAKVPNAE DVKSMMMQKAMKKTNLPLAFETVIGAGTKRDQIYKVAPKKIGYLHAYAPAVNEKGKVT YGEVYLVLKGNKRKLVVKNVTSQGIGAWIPVQDHVTFGFQLSSLPR*" /label="yfkD CDS" gene 815908..816702 /gene="yfkD" /locus_tag="BSU_07930" /old_locus_tag="BSU07930" /label="yfkD gene" downshifts 816690 /Source="Nicolas_upshifts" /id="D396" /incds=0 /nref=41 /ntot=100 /MaxReadThrough="0.82657" /MaxDrop="5.7252" /score="28.7014976" /energy="-9.5" /TU="NA" /idTUdmin="U605" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(816741..817583) /gene="mscC" /locus_tag="BSU_07940" /old_locus_tag="BSU07940" /function="16.1: Circulate" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17665170, 18310427, 19252899" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17665170, 18310427, 19252899; Product type t: transporter" /codon_start=1 /transl_table=11 /product="mechanosensitive ion channel" /protein_id="NP_388675.1" /db_xref="EnsemblGenomes-Gn:BSU07940" /db_xref="EnsemblGenomes-Tr:CAB12623" /db_xref="GOA:O35043" /db_xref="InterPro:IPR006685" /db_xref="InterPro:IPR010920" /db_xref="InterPro:IPR011014" /db_xref="SubtiList:BG12920" /db_xref="UniProtKB/Swiss-Prot:O35043" /translation="MRMKETLTEIFQNKIVDILLVAVILWIGVFIINRLVQLFFKRTD FIEEKKEKTIESLVRSVTQYTATIGFIFYVISLFVHDFGKILAGAGVAGIVIGFGAQS LIKDVLAGVFLIYERQLHKGDYVTVNNLFNGTVEEIGLRSLQIREWSGKLLTISNGEV RQIENYNIDFMRITESFLISFKEDPDRVYSVLEEACDMLNEELRDSLKRDEFGNPTEP FQIHGITALNKINRGVEFTVKGMVKDDDYFSASLAVRRVLVRQLYQNNVQMLEEAVRI ERTQ*" /label="mscC CDS" gene complement(816741..817583) /gene="mscC" /locus_tag="BSU_07940" /old_locus_tag="BSU07940" /label="mscC gene" downshifts complement(816743) /Source="Nicolas_upshifts" /id="D397" /incds=0 /nref=58 /ntot=230 /MaxReadThrough="1.96922" /MaxDrop="4.8789" /score="23.5281308" /energy="-9.8" /TU="NA" /idTUdmin="U609" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(817584..818705) /gene="yfkA" /locus_tag="BSU_07955" /old_locus_tag="BSU07955" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative Fe-S oxidoreductase, radical SAM superfamily" /protein_id="NP_388677.2" /db_xref="EnsemblGenomes-Gn:BSU07955" /db_xref="EnsemblGenomes-Tr:CAB12625" /db_xref="GOA:O34400" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR014866" /db_xref="InterPro:IPR031004" /db_xref="InterPro:IPR034395" /db_xref="SubtiList:BG12918" /db_xref="UniProtKB/Swiss-Prot:O34400" /translation="MTQNTKLRPITPEFDPWEAYMDVDQYGDMQLTNVEFTTTTLCNM RCEHCAVGYTLQPKDPNALPIDLLLKRLEEIPRLRSISITGGEPMLSLKSVKEYVVPL LKYAHERGVRTQINSNLTLDIERYEWIIPYLDVLHISHNWGTVEDFAEIGFAMMDRKP TFEQRARYFEKMIENSRTLVDAGVMVSAETMLNKRTLPHIEHIHRQITEDMKCQRHEV HPMYPSDFASALESLSLKEMRQAIHRLLDIRDENTWMLFGTLPFYACSPDEDDQKLLR RLRAAKNVTVRNDPDGRSRLNVNIFDGNIIVTDFGDTPPLGNIQTDSLPSAYEKWRET KLAKELSCHCPNVRCLGPNVLVKNSYYQDTDFTKRQARS*" /label="yfkA CDS" gene complement(817584..818705) /gene="yfkA" /locus_tag="BSU_07955" /old_locus_tag="BSU07955" /label="yfkA gene" promotor_-10 complement(818746..818765) /Source="Nicolas_upshift_promotors" /id="U609" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.942057942057942" /psig=1 /xcortree=2517 /SigmaFactorBS="atggtagctcattttttgccgtttttcaatcgccgcgctACT TGcgatcttggcaaatcAGGTCTAAAATTAACTGTTGgcagcgttagtatgcccattt a" /listShort="yfkA, yfkC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(818764) /Source="Nicolas_upshifts" /id="U609" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.942057942057942" /psig=1 /xcortree=2517 /SigmaFactorBS="atggtagctcattttttgccgtttttcaatcgccgcgctACT TGcgatcttggcaaatcAGGTCTAAAATTAACTGTTGgcagcgttagtatgcccattt a" /listShort="yfkA, yfkC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(818781..818785) /Source="Nicolas_upshift_promotors" /id="U609" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.942057942057942" /psig=1 /xcortree=2517 /SigmaFactorBS="atggtagctcattttttgccgtttttcaatcgccgcgctACT TGcgatcttggcaaatcAGGTCTAAAATTAACTGTTGgcagcgttagtatgcccattt a" /listShort="yfkA, yfkC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 818793..818800 /Source="Nicolas_upshift_promotors" /id="U610" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.537462537462537" /psig=1 /xcortree=574 /SigmaFactorBS="ctgatttgccaagatcgcaagtagcgcggCGATTGAAaaacg gcaaaaaaTGAGCTACCATAATAAAAAAtgaatggaggaacagaatggggaacgccgt a" /listShort="yfjT, pdaA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 818814..818833 /Source="Nicolas_upshift_promotors" /id="U610" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.537462537462537" /psig=1 /xcortree=574 /SigmaFactorBS="ctgatttgccaagatcgcaagtagcgcggCGATTGAAaaacg gcaaaaaaTGAGCTACCATAATAAAAAAtgaatggaggaacagaatggggaacgccgt a" /listShort="yfjT, pdaA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 818824 /Source="Nicolas_upshifts" /id="U610" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.537462537462537" /psig=1 /xcortree=574 /SigmaFactorBS="ctgatttgccaagatcgcaagtagcgcggCGATTGAAaaacg gcaaaaaaTGAGCTACCATAATAAAAAAtgaatggaggaacagaatggggaacgccgt a" /listShort="yfjT, pdaA" /GFF_Attribute="listLong" /label="upshifts" CDS 818850..819035 /gene="yfjT" /locus_tag="BSU_07970" /old_locus_tag="BSU07970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388678.1" /db_xref="EnsemblGenomes-Gn:BSU07970" /db_xref="EnsemblGenomes-Tr:CAB12626" /db_xref="SubtiList:BG12916" /db_xref="UniProtKB/Swiss-Prot:O35041" /translation="MGNAVNNKDQQIDYLKNRLDMFMNVIDSLDPEATDVEDIDRLIS MLDDLEAKYERFKKDWE*" /label="yfjT CDS" gene 818850..819035 /gene="yfjT" /locus_tag="BSU_07970" /old_locus_tag="BSU07970" /label="yfjT gene" downshifts 819014 /Source="Nicolas_upshifts" /id="D398" /incds=0 /nref=15 /ntot=177 /MaxReadThrough="3.03457" /MaxDrop="3.24661" /score="14.1645187" /energy="-6.4" /TU="U610" /idTUdmin="U610" /TUdmin="-559" /isTUend="FALSE" /label="downshifts" promotor_-35 819078..819084 /Source="Nicolas_upshift_promotors" /id="U611" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.95004995004995" /psig="0.95004995004995" /xcortree=930 /SigmaFactorBS="gaataaaaccgcgtgcccgccgcggtttttttattggcataa agcaacAGTATAAaacaaagtctctatCTGTAAAATAAGaaaaaatgcagaaggagcg c" /listShort="pdaA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 819090 /Source="Nicolas_upshifts" /id="U611" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.95004995004995" /psig="0.95004995004995" /xcortree=930 /SigmaFactorBS="gaataaaaccgcgtgcccgccgcggtttttttattggcataa agcaacAGTATAAaacaaagtctctatCTGTAAAATAAGaaaaaatgcagaaggagcg c" /listShort="pdaA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 819099..819110 /Source="Nicolas_upshift_promotors" /id="U611" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.95004995004995" /psig="0.95004995004995" /xcortree=930 /SigmaFactorBS="gaataaaaccgcgtgcccgccgcggtttttttattggcataa agcaacAGTATAAaacaaagtctctatCTGTAAAATAAGaaaaaatgcagaaggagcg c" /listShort="pdaA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 819136..819927 /gene="pdaA" /locus_tag="BSU_07980" /old_locus_tag="BSU07980" /EC_number="3.5.1.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:14679227, 15687192" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14679227, 15687192; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exported peptidoglycan N-acetylmuramic acid deacetylase" /protein_id="NP_388679.1" /db_xref="EnsemblGenomes-Gn:BSU07980" /db_xref="EnsemblGenomes-Tr:CAB12627" /db_xref="GOA:O34928" /db_xref="InterPro:IPR002509" /db_xref="InterPro:IPR011330" /db_xref="InterPro:IPR014235" /db_xref="PDB:1NY1" /db_xref="PDB:1W17" /db_xref="PDB:1W1A" /db_xref="PDB:1W1B" /db_xref="SubtiList:BG12915" /db_xref="UniProtKB/Swiss-Prot:O34928" /translation="MKWMCSICCAAVLLAGGAAQAEAVPNEPINWGFKRSVNHQPPDA GKQLNSLIEKYDAFYLGNTKEKTIYLTFDNGYENGYTPKVLDVLKKHRVTGTFFVTGH FVKDQPQLIKRMSDEGHIIGNHSFHHPDLTTKTADQIQDELDSVNEEVYKITGKQDNL YLRPPRGVFSEYVLKETKRLGYQTVFWSVAFVDWKINNQKGKKYAYDHMIKQAHPGAI YLLHTVSRDNAEALDDAITDLKKQGYTFKSIDDLMFEKEMRLPSL*" /label="pdaA CDS" gene 819136..819927 /gene="pdaA" /locus_tag="BSU_07980" /old_locus_tag="BSU07980" /label="pdaA gene" downshifts 819925 /Source="Nicolas_upshifts" /id="D399" /incds=0 /nref=1 /ntot=36 /MaxReadThrough="2.12067" /MaxDrop="3.4013" /score="14.4741934" /energy="-10.2" /TU="NA" /idTUdmin="U611" /TUdmin=22 /isTUend="TRUE" /label="downshifts" CDS complement(819965..820825) /gene="yfjR" /locus_tag="BSU_07990" /old_locus_tag="BSU07990" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20512483; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative beta-hydroxyacid dehydrogenase" /protein_id="NP_388680.2" /db_xref="EnsemblGenomes-Gn:BSU07990" /db_xref="EnsemblGenomes-Tr:CAB12628" /db_xref="GOA:O34969" /db_xref="InterPro:IPR006115" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR015815" /db_xref="InterPro:IPR029154" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12914" /db_xref="UniProtKB/Swiss-Prot:O34969" /translation="MKIAVIGLGNMGQPIARNVLQAGYELTVYNRTKQKTEDLVTEGA QAADTPRLAAKSADIVITMLADDDSVSTVTFGEDGLLEGLAENGIHISMSTISVEFSE KLAAAHAEKGQFFLAAPVLGRPDAAAKAALRIITAGPAEAKQAAKPLLDSLSQQIFDV GEESKTANAAKISINFLLVSMLEALSESFLMMEKYGLEQKQFLEIASALFGSPVYQNY GTIMAEQKFEPAGFKMSLGLKDTNLALAAAKRVSANLPLAELAKSHFESGIEKGFGDL DWAALIKCIK*" /label="yfjR CDS" gene complement(819965..820825) /gene="yfjR" /locus_tag="BSU_07990" /old_locus_tag="BSU07990" /label="yfjR gene" downshifts complement(819979) /Source="Nicolas_upshifts" /id="D400" /incds=0 /nref=15 /ntot=193 /MaxReadThrough="2.61589" /MaxDrop="3.98341" /score="-1.3382901" /energy="-12.1" /TU="NA" /idTUdmin="U612" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(820845..820864) /Source="Nicolas_upshift_promotors" /id="U612" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=1961 /SigmaFactorBS="agcgagcagctgttcttttttgttgtaagccgatcgCTATgc atattctgttcatATTGTTTATAATGGAAAAAAtattcagggagtgattagattgaaa a" /listShort="yfjR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(820859) /Source="Nicolas_upshifts" /id="U612" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=1961 /SigmaFactorBS="agcgagcagctgttcttttttgttgtaagccgatcgCTATgc atattctgttcatATTGTTTATAATGGAAAAAAtattcagggagtgattagattgaaa a" /listShort="yfjR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(820880..820883) /Source="Nicolas_upshift_promotors" /id="U612" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=1961 /SigmaFactorBS="agcgagcagctgttcttttttgttgtaagccgatcgCTATgc atattctgttcatATTGTTTATAATGGAAAAAAtattcagggagtgattagattgaaa a" /listShort="yfjR" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(820924..821883) /gene="yfjQ" /locus_tag="BSU_08000" /old_locus_tag="BSU08000" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14563871, 24415722; Product type t: transporter" /codon_start=1 /transl_table=11 /product="divalent cation (octahedral coordination) transporter" /protein_id="NP_388681.1" /db_xref="EnsemblGenomes-Gn:BSU08000" /db_xref="EnsemblGenomes-Tr:CAB12629" /db_xref="GOA:O31543" /db_xref="InterPro:IPR002523" /db_xref="InterPro:IPR004488" /db_xref="SubtiList:BG12913" /db_xref="UniProtKB/Swiss-Prot:O31543" /translation="MINITAITTEHQLLKNIPIERVEQPDIAWYWVDFYGPEDTETAL LRDFFHFHPLAIEDCFQHMQRPKLDHYDGYRFYVIHALNKETLETEEVDIFQGEKFVV TFHLHETPGIAKVRERLYASPDILKKGPGHISYMIMDQLVDEYFPLVYKIEDRLNEIE ESRPHKTYGTLMNEVFDLRTDLLHLRRTIIPMRDLLYRILSLDHVKEQRETKAYFSDI YDHLLKLSEIVESNRDMTSDLRDSYVTLNSNRMNAIMMTLTIVSTIFIPLTFIAGVYG MNFDFMPELHWKYGYFAVLGLMAALVIGMLIWFVHKGWFNIFK*" /label="yfjQ CDS" gene complement(820924..821883) /gene="yfjQ" /locus_tag="BSU_08000" /old_locus_tag="BSU08000" /label="yfjQ gene" downshifts complement(820947) /Source="Nicolas_upshifts" /id="D401" /incds=0 /nref=137 /ntot=224 /MaxReadThrough="2.29296" /MaxDrop="4.2496" /score="10.2736001" /energy="-7.5" /TU="NA" /idTUdmin="U613" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(821894..821913) /Source="Nicolas_upshift_promotors" /id="U613" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.888111888111888" /psig="0.993006993006993" /xcortree=1816 /SigmaFactorBS="tggaattaggcagagagtaccgtatACTTttctcataaagac cgCATGATATAATGGCAGGTGGagggttgtttatgatcaacattaccgcaatcacaac a" /listShort="yfjQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(821897) /Source="Nicolas_upshifts" /id="U613" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.888111888111888" /psig="0.993006993006993" /xcortree=1816 /SigmaFactorBS="tggaattaggcagagagtaccgtatACTTttctcataaagac cgCATGATATAATGGCAGGTGGagggttgtttatgatcaacattaccgcaatcacaac a" /listShort="yfjQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(821929..821932) /Source="Nicolas_upshift_promotors" /id="U613" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.888111888111888" /psig="0.993006993006993" /xcortree=1816 /SigmaFactorBS="tggaattaggcagagagtaccgtatACTTttctcataaagac cgCATGATATAATGGCAGGTGGagggttgtttatgatcaacattaccgcaatcacaac a" /listShort="yfjQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 821944..821948 /Source="Nicolas_upshift_promotors" /id="U614" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.832167832167832" /psig="0.999000999001" /xcortree=2271 /SigmaFactorBS="atgcggtctttatgagaaaagtatacggtactcTCTGCctaa ttccagcggCATGTTATACTGAACAAAAAcggaaaaaagggtggatctcatgtggaag g" /listShort="yfjP, S277, yfjO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 821962..821981 /Source="Nicolas_upshift_promotors" /id="U614" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.832167832167832" /psig="0.999000999001" /xcortree=2271 /SigmaFactorBS="atgcggtctttatgagaaaagtatacggtactcTCTGCctaa ttccagcggCATGTTATACTGAACAAAAAcggaaaaaagggtggatctcatgtggaag g" /listShort="yfjP, S277, yfjO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 821971 /Source="Nicolas_upshifts" /id="U614" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.832167832167832" /psig="0.999000999001" /xcortree=2271 /SigmaFactorBS="atgcggtctttatgagaaaagtatacggtactcTCTGCctaa ttccagcggCATGTTATACTGAACAAAAAcggaaaaaagggtggatctcatgtggaag g" /listShort="yfjP, S277, yfjO" /GFF_Attribute="listLong" /label="upshifts" CDS 822002..822865 /gene="yfjP" /locus_tag="BSU_08010" /old_locus_tag="BSU08010" /EC_number="3.2.2.21" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative DNA-3-methyladenine glycosylase" /protein_id="NP_388682.1" /db_xref="EnsemblGenomes-Gn:BSU08010" /db_xref="EnsemblGenomes-Tr:CAB12630" /db_xref="GOA:O31544" /db_xref="InterPro:IPR003265" /db_xref="InterPro:IPR011257" /db_xref="InterPro:IPR023170" /db_xref="SubtiList:BG12912" /db_xref="UniProtKB/Swiss-Prot:O31544" /translation="MWKEKVSVTPPYHFDRVLDRLSLDPLNAVDREAREVRVPIRNQA GDVCIVKVQALGHAGEPEFLVSGETDQGEMMKEIKRIFQWENHLQHVLDHFSKTSLSA IFEEHAGTPLVLDYSVYNCMMKCIIHQQLNLSFAYTLTERFVHAFGEQKDGVWCYPKP ETIAELDYQDLRDLQFSMRKAEYTIDTSRMIAEGTLSLSELPHMADEDIMKKLIKIRG IGPWTVQNVLMFGLGRPNLFPLADIGLQNAIKRHFQLDDKPAKDVMLAMSKEWEPYLS YASLYLWRSIE*" /label="yfjP CDS" gene 822002..822865 /gene="yfjP" /locus_tag="BSU_08010" /old_locus_tag="BSU08010" /label="yfjP gene" S_feature 822866..822978 /Source="Nicolas_S_feature" /locus_tag="new_873289_873401" /HighExp="BC, M40t90, LBGtran, C90, M9-stat, M0t90, Lbtran, Sw, M40t45, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S277" CDS 822979..824379 /gene="yfjO" /locus_tag="BSU_08020" /old_locus_tag="BSU08020" /EC_number="2.1.1.-" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA methyltransferase" /protein_id="NP_388683.1" /db_xref="EnsemblGenomes-Gn:BSU08020" /db_xref="EnsemblGenomes-Tr:CAB12631" /db_xref="GOA:O31545" /db_xref="InterPro:IPR001566" /db_xref="InterPro:IPR002792" /db_xref="InterPro:IPR010280" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR029063" /db_xref="InterPro:IPR030390" /db_xref="InterPro:IPR030391" /db_xref="SubtiList:BG12911" /db_xref="UniProtKB/Swiss-Prot:O31545" /translation="MNQQKKQAPVELKVGQTFPLTIKRLGINGEGVGYFKKKVVFVPG ALPGEEVVVQATKVQPKFSEGRIKKIRKASEHRVAPPCPVYEQCGGCQLQHLAYSQQL REKRDIVIQSLERHTKFKVENMEIKETIGMDNPWNYRNKSQFQIGRSQSGSIIAGLYG LDSHDIVPIKDCIVQHPATNKTTGIVRRILEDFNVSVYNERKRKGDVRTIVTRVGFET GEVQVVLVTAKETLPHKEEIVKAIQKRLPEVKSIIQNVNGAKTSVIFGEKTKQLAGKT VIQEVLGDVSFELSARAFFQLNPEQTVKLYDEVKKAAQLTGKEKVVDAYCGVGTIGMW VADGAKEVRGMDVIKESIDDAKKNAKKHGMANATYVTGTAEHWLPKWTKEGFRPDVVI VDPPRTGCDSTFLDTIKKVKPKRFVYVSCNPSTLAKDLQTLSKDYRVDYIQPVDMFPQ TAHVEAVARLVLKSSN*" /label="yfjO CDS" gene 822979..824379 /gene="yfjO" /locus_tag="BSU_08020" /old_locus_tag="BSU08020" /label="yfjO gene" downshifts 824391 /Source="Nicolas_upshifts" /id="D402" /incds=0 /nref=198 /ntot=251 /MaxReadThrough="1.18186" /MaxDrop="5.19313" /score="11.8630961" /energy="-12.6" /TU="NA" /idTUdmin="U614" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 824685..824692 /Source="Nicolas_upshift_promotors" /id="U615" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2924 /SigmaFactorBS="tagatgtattttcataatttgtaaaattataTATTGACTtgc agttattacgtgTGAAATATTGATGATAGGAAtataaggaaagtatggcgtatatcat t" /listShort="S278, yfzA, S279" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 824708..824727 /Source="Nicolas_upshift_promotors" /id="U615" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2924 /SigmaFactorBS="tagatgtattttcataatttgtaaaattataTATTGACTtgc agttattacgtgTGAAATATTGATGATAGGAAtataaggaaagtatggcgtatatcat t" /listShort="S278, yfzA, S279" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 824714 /Source="Nicolas_upshifts" /id="U615" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2924 /SigmaFactorBS="tagatgtattttcataatttgtaaaattataTATTGACTtgc agttattacgtgTGAAATATTGATGATAGGAAtataaggaaagtatggcgtatatcat t" /listShort="S278, yfzA, S279" /GFF_Attribute="listLong" /label="upshifts" S_feature 824721..825004 /Source="Nicolas_S_feature" /locus_tag="new_875144_875427" /HighExp="M9-stat, T1.30H, T0.30H, T2.0H, LoTm, T3.0H, T3.30H, T1.0H, T2.30H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.69102300000000005" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S278" CDS 825005..825271 /gene="yfzA" /locus_tag="BSU_08029" /old_locus_tag="BSU08029" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097694.1" /db_xref="EnsemblGenomes-Gn:BSU08029" /db_xref="EnsemblGenomes-Tr:CAX52581" /db_xref="GOA:C0H3X6" /db_xref="InterPro:IPR025627" /db_xref="UniProtKB/Swiss-Prot:C0H3X6" /translation="MDKVYKRSWFQTFLAFLVSQLYFNFVELTGWGPKYREMNGFPAN IVELDFFQTYLSFYDNPWFNIITVFLGVFTIIQIITGITKDIRN*" /label="yfzA CDS" gene 825005..825271 /gene="yfzA" /locus_tag="BSU_08029" /old_locus_tag="BSU08029" /label="yfzA gene" promotor_-10 complement(825219..825238) /Source="Nicolas_upshift_promotors" /id="U616" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.936063936063936" /psig=1 /xcortree=2926 /SigmaFactorBS="taaataaggcatcagaagttattgctttaatttcgaatatcC TTTgttatccctgtaatTATTTGTATAATAGTGAAAActcccaagaaaacagtaataa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(825237) /Source="Nicolas_upshifts" /id="U616" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.936063936063936" /psig=1 /xcortree=2926 /SigmaFactorBS="taaataaggcatcagaagttattgctttaatttcgaatatcC TTTgttatccctgtaatTATTTGTATAATAGTGAAAActcccaagaaaacagtaataa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(825253..825256) /Source="Nicolas_upshift_promotors" /id="U616" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.936063936063936" /psig=1 /xcortree=2926 /SigmaFactorBS="taaataaggcatcagaagttattgctttaatttcgaatatcC TTTgttatccctgtaatTATTTGTATAATAGTGAAAActcccaagaaaacagtaataa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 825272..825753 /Source="Nicolas_S_feature" /locus_tag="new_875695_876176" /HighExp="G180, Paraq, H2O2, G135, Oxctl, G150, C30, LoTm, S8, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S279" promotor_-35 825724..825727 /Source="Nicolas_upshift_promotors" /id="U617" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.591408591408591" /psig=1 /xcortree=2598 /SigmaFactorBS="atcttcaataacagggcaattattttgcgTTGGtaatatgga gaactcaTATGATATTCTATTTAGGTTggaatcctttttatccaaaaagttcaaaagc a" /listShort="S280, dusC, S281, yfjM, yfjL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 825744..825763 /Source="Nicolas_upshift_promotors" /id="U617" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.591408591408591" /psig=1 /xcortree=2598 /SigmaFactorBS="atcttcaataacagggcaattattttgcgTTGGtaatatgga gaactcaTATGATATTCTATTTAGGTTggaatcctttttatccaaaaagttcaaaagc a" /listShort="S280, dusC, S281, yfjM, yfjL" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 825755..826002 /Source="Nicolas_S_feature" /locus_tag="new_876178_876425" /HighExp="H2O2, G180, Paraq, G150, G135, Oxctl, dia15, LBGstat, LBGexp, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S280" upshifts 825755 /Source="Nicolas_upshifts" /id="U617" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.591408591408591" /psig=1 /xcortree=2598 /SigmaFactorBS="atcttcaataacagggcaattattttgcgTTGGtaatatgga gaactcaTATGATATTCTATTTAGGTTggaatcctttttatccaaaaagttcaaaagc a" /listShort="S280, dusC, S281, yfjM, yfjL" /GFF_Attribute="listLong" /label="upshifts" CDS 826003..826980 /gene="dusC" /locus_tag="BSU_08030" /old_locus_tag="BSU08030" /EC_number="1.-.-.-" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11983710, 25902496; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA-dihydrouridine synthase 2" /protein_id="NP_388684.1" /db_xref="EnsemblGenomes-Gn:BSU08030" /db_xref="EnsemblGenomes-Tr:CAB12632" /db_xref="GOA:O31546" /db_xref="InterPro:IPR001269" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR018517" /db_xref="InterPro:IPR024036" /db_xref="InterPro:IPR035587" /db_xref="SubtiList:BG12910" /db_xref="UniProtKB/Swiss-Prot:O31546" /translation="MTENFWRELPRPFFVLAPMEDVTDVVFRHVVSEAGRPDVFFTEF TNSESYCHPDGKDSVRGRLTFTEDEQPIVAHIWGDKPENFRKMSIGMAELGFKGLDIN MGCPVPNVAGNGKGSGLICRPAVAAELIQAAKAGGLPVSVKTRLGYTDVDEWREWLTH ILKQDIANLSIHLRTRAEMSKVDAHWELIPEIKKLRDEVAPDTLLTINGDIPDRQTGL KLAEQYGVDGIMIGRGIFTNPFAFEKEPKEHSSKELLDLLRLHLDLHDEYSKEEARPY KPLPRFFKIYLRGFRGASELRNQCMNTKSTDEVRALLDDFERKYLDGIE*" /label="dusC CDS" gene 826003..826980 /gene="dusC" /locus_tag="BSU_08030" /old_locus_tag="BSU08030" /label="dusC gene" S_feature 826981..827073 /Source="Nicolas_S_feature" /locus_tag="new_877404_877496" /HighExp="G135, G180, Paraq, G150, H2O2, LBGexp, aero, dia0, Oxctl, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S281" downshifts 827030 /Source="Nicolas_upshifts" /id="D403" /incds=0 /nref=86 /ntot=218 /MaxReadThrough="3.30163" /MaxDrop="4.0519" /score="11.8630961" /energy="-12.6" /TU="U617" /idTUdmin="U618" /TUdmin="-1211" /isTUend="FALSE" /label="downshifts" promotor_-35 827114..827120 /Source="Nicolas_upshift_promotors" /id="U618" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.994005994005994" /psig="0.999000999001" /xcortree=3192 /SigmaFactorBS="gtacgcagcttttactcagcctgtcttttctctAATTTATtg taagaaaatAATGGTATATTTAGTGGAGAtatcatataaagggggagaggaaaatgaa a" /listShort="yfjM, yfjL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 827132..827151 /Source="Nicolas_upshift_promotors" /id="U618" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.994005994005994" /psig="0.999000999001" /xcortree=3192 /SigmaFactorBS="gtacgcagcttttactcagcctgtcttttctctAATTTATtg taagaaaatAATGGTATATTTAGTGGAGAtatcatataaagggggagaggaaaatgaa a" /listShort="yfjM, yfjL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 827141 /Source="Nicolas_upshifts" /id="U618" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.994005994005994" /psig="0.999000999001" /xcortree=3192 /SigmaFactorBS="gtacgcagcttttactcagcctgtcttttctctAATTTATtg taagaaaatAATGGTATATTTAGTGGAGAtatcatataaagggggagaggaaaatgaa a" /listShort="yfjM, yfjL" /GFF_Attribute="listLong" /label="upshifts" CDS 827176..827628 /gene="yfjM" /locus_tag="BSU_08040" /old_locus_tag="BSU08040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388685.1" /db_xref="EnsemblGenomes-Gn:BSU08040" /db_xref="EnsemblGenomes-Tr:CAB12633" /db_xref="SubtiList:BG12909" /db_xref="UniProtKB/Swiss-Prot:O31547" /translation="MKRLCIIPCGKKKIWDVQPDAGPVRAEDAYLSPFHQACERYAKT FFDEWVILSAKHGFLRPDDLVSGNYDVTFGTGHPEIMTADELRRQFHEKGFSDIEELV MLGGKKYRSVLNAVIGEHQHISWPLSSYKGIGYMLQALNRAVEEKHEL*" /label="yfjM CDS" gene 827176..827628 /gene="yfjM" /locus_tag="BSU_08040" /old_locus_tag="BSU08040" /label="yfjM gene" CDS 827658..828347 /gene="yfjL" /locus_tag="BSU_08050" /old_locus_tag="BSU08050" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388686.1" /db_xref="EnsemblGenomes-Gn:BSU08050" /db_xref="EnsemblGenomes-Tr:CAB12634" /db_xref="InterPro:IPR020523" /db_xref="SubtiList:BG11034" /db_xref="UniProtKB/Swiss-Prot:P40773" /translation="MKKLVFGLLAIVLFGCGLYIYHVWFGDPFSKNAAEQKLVSYVKQ TYPKKEIKITNGVYNAKTSEYVFEATSQSHRYPMCTKGFLHPKVTCDGIEEAYTESVA KHVNEEATKAIEADLKKAVPRFIKADAALSIENGQFTLDTKWNKKLAEKAPMSMTIQL DASGLSKTDAAKMAETVRKTLNEKGYTYSNGTIDCMQKDGDGGIGYVKYSIDFLSKAA IQSNDAEELGS*" /label="yfjL CDS" gene 827658..828347 /gene="yfjL" /locus_tag="BSU_08050" /old_locus_tag="BSU08050" /label="yfjL gene" downshifts 828352 /Source="Nicolas_upshifts" /id="D404" /incds=0 /nref=31 /ntot=205 /MaxReadThrough="0.02745" /MaxDrop="3.61164" /score="23.9796437" /energy="-9" /TU="NA" /idTUdmin="U617" /TUdmin=1 /isTUend="TRUE" /label="downshifts" misc_feature 828524..828542 /Source="Nicolas_upshift_promotors" /id="U619" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.878121878121878" /psig="0.878121878121878" /xcortree=351 /SigmaFactorBS="caaactgtctccaaagtgaagatgagaagactgattttacgg gctcaaaagacTGGCACACTTCTTGCATTTataatggtgaaccctaaatagaaggagg c" /listShort="acoA, acoB, acoC, acoL, acoR, sspH" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 828531 /Source="Nicolas_upshifts" /id="U619" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.878121878121878" /psig="0.878121878121878" /xcortree=351 /SigmaFactorBS="caaactgtctccaaagtgaagatgagaagactgattttacgg gctcaaaagacTGGCACACTTCTTGCATTTataatggtgaaccctaaatagaaggagg c" /listShort="acoA, acoB, acoC, acoL, acoR, sspH" /GFF_Attribute="listLong" /label="upshifts" CDS 828579..829580 /gene="acoA" /locus_tag="BSU_08060" /old_locus_tag="BSU08060" /EC_number="1.1.1.303" /EC_number="2.3.1.190" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10368162, 11274109, 22714279" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10368162, 11274109, 22714279; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetoin dehydrogenase E1 component (TPP-dependent alpha subunit)" /protein_id="NP_388687.1" /db_xref="EnsemblGenomes-Gn:BSU08060" /db_xref="EnsemblGenomes-Tr:CAB12635" /db_xref="GOA:O31404" /db_xref="InterPro:IPR001017" /db_xref="InterPro:IPR029061" /db_xref="SubtiList:BG12558" /db_xref="UniProtKB/Swiss-Prot:O31404" /translation="MKLLKREGLSLTEEKALWMYQKMLEIRGFEDKVHELFAQGVLPG FVHLYAGEEAVAVGVCAHLHDGDSITSTHRGHGHCIAKGCDLDGMMAEIFGKATGLCK GKGGSMHIADLDKGMLGANGIVGGGFTLACGSALTAKYKQTKNVSVCFFGDGANNQGT FHEGLNLAAVWNLPVVFVAENNGYGEATPFEYASACDSIADRAAAYNMPGVTVDGKDI LAVYQAAEEAIERARNGGGPSLIECMTYRNYGHFEGDAQTYKTKDERVEHLEEKDAIQ GFKNYLLKETDANKLSDIEQRVSESIEKAVSFSEDSPYPKDSELLTDVYVSYEKGGM* " /label="acoA CDS" gene 828579..829580 /gene="acoA" /locus_tag="BSU_08060" /old_locus_tag="BSU08060" /label="acoA gene" CDS 829584..830612 /gene="acoB" /locus_tag="BSU_08070" /old_locus_tag="BSU08070" /EC_number="1.1.1.303" /EC_number="2.3.1.190" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11274109, 10368162" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11274109, 10368162; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetoin dehydrogenase E1 component (TPP-dependent beta subunit)" /protein_id="NP_388688.1" /db_xref="EnsemblGenomes-Gn:BSU08070" /db_xref="EnsemblGenomes-Tr:CAB12636" /db_xref="GOA:O34591" /db_xref="InterPro:IPR005475" /db_xref="InterPro:IPR009014" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR033248" /db_xref="SubtiList:BG12559" /db_xref="UniProtKB/Swiss-Prot:O34591" /translation="MARVISMSDAINEAMKLAMRKDENVLLIGEDVAGGAAVDHLQDD EAWGGVLGVTKGLVQEFGRTRVLDTPISEAGYMGAAMAAASTGLRPIAELMFNDFIGT CFDQVINQGAKFRYMFGGKAQVPITVRTTYGAGFRAAAQHSQSLYGLFTSIPGLKTVV PSNPYDAKGLLLAAIEDNDPVFFFEDKTSYNMKGEVPEDYYTIPLGKADIKREGNDVT LFAVGKQVNTALEAAAQLSERGIEAEVLDPRSLSPLDEDAIFTSLEKTNRLIIIDEAN PRCSIATDIAALVADKGFDLLDAPIKRITAPHTPVPFSPVLEDQYLPTPDKIVSVTLE LLGEPALN*" /label="acoB CDS" gene 829584..830612 /gene="acoB" /locus_tag="BSU_08070" /old_locus_tag="BSU08070" /label="acoB gene" CDS 830626..831822 /gene="acoC" /locus_tag="BSU_08080" /old_locus_tag="BSU08080" /EC_number="2.3.1.12" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10368162, 11274109" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10368162, 11274109; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetoin dehydrogenase E2 component (dihydrolipoamide acetyltransferase)" /protein_id="NP_388689.1" /db_xref="EnsemblGenomes-Gn:BSU08080" /db_xref="EnsemblGenomes-Tr:CAB12637" /db_xref="GOA:O31550" /db_xref="InterPro:IPR000089" /db_xref="InterPro:IPR001078" /db_xref="InterPro:IPR004167" /db_xref="InterPro:IPR011053" /db_xref="InterPro:IPR036625" /db_xref="SubtiList:BG12560" /db_xref="UniProtKB/Swiss-Prot:O31550" /translation="MAVKVVMPKLGMAMKQGEVSIWNKKVGDPVEKGESIASIQSEKI EMEIEAPEKGTLIDIKVKEGEEVPPGTAICYIGDANESVQEEAGAPVAEDNMPQAVQP VKQENKPAASKKDRMKISPVARKIAEKAGLDLKQLKGTGPGGRIVKDDVTKALAEQKK DQAKPVSEQKAQEIPVTGMRKVIAARMQESLANSAQLTITMKADITKLATLQKQLSPT AEERYGTKLTITHFVSRAAVLALQAHPVLNSFYQNERIITHPHVHLGMAVALENGLVV PVIRHAEKLSLIELAQSISENAKKAREGRAGSEELQGSTFSITNLGAFGVEHFTPILN PPETGILGIGASYDTPVYQGEEIVRSTILPLSLTFDHRACDGAPAAAFLKAMKTYLEE PAALIL*" /label="acoC CDS" gene 830626..831822 /gene="acoC" /locus_tag="BSU_08080" /old_locus_tag="BSU08080" /label="acoC gene" downshifts complement(830627) /Source="Nicolas_upshifts" /id="D405" /incds=0 /nref=8 /ntot=46 /MaxReadThrough="0.481579999999999" /MaxDrop="4.16582" /score="-0.0231058321" /energy="-9.9" /TU="NA" /idTUdmin="U623" /TUdmin=4796 /isTUend="FALSE" /label="downshifts" CDS 831843..833219 /gene="acoL" /locus_tag="BSU_08090" /old_locus_tag="BSU08090" /EC_number="1.8.1.4" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11274109, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11274109, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetoin dehydrogenase E3 component (dihydrolipoamide dehydrogenase)" /protein_id="NP_388690.1" /db_xref="EnsemblGenomes-Gn:BSU08090" /db_xref="EnsemblGenomes-Tr:CAB12638" /db_xref="GOA:O34324" /db_xref="InterPro:IPR001100" /db_xref="InterPro:IPR004099" /db_xref="InterPro:IPR006258" /db_xref="InterPro:IPR012999" /db_xref="InterPro:IPR016156" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG12561" /db_xref="UniProtKB/Swiss-Prot:O34324" /translation="MTLAIIGGGPAGYAAAVSAAQQGRNVLLIDKGKLGGTCLNEGCI PTKSLLESANVLDKIKHADSFGIELPAGAISVDWSKMQSRKQQVVSQLVQGVQYLMKK NQIQVVKGTASFLSERKLLIEGENGKEIREADQVLIASGSEPIELPFAPFDGEWILDS KDALSLSEIPSSLVIVGGGVIGCEYAGLFARLGSQVTIIETADRLIPAEDEDIARLFQ EKLEEDGVEVHTSSRLGRVDQTAKTAIWKSGQREFKTKADYVLVAIGRKPRLDGLQLE QAGVDFSPKGIPVNGHMQTNVPHIYACGDAIGGIQLAHAAFHEGIIAASHASGRDVKI NEKHVPRCIYTSPEIACIGMTERQARSIYGDVKIGEFSFSANGKALIKQQAEGKVKIM AEPEFGEIVGVSMIGPDVTELIGQAAAIMNGEMTADMAEHFIAAHPTLSETLHEALLS TIGLAVHA*" /label="acoL CDS" gene 831843..833219 /gene="acoL" /locus_tag="BSU_08090" /old_locus_tag="BSU08090" /label="acoL gene" downshifts 833213 /Source="Nicolas_upshifts" /id="D406" /incds=0 /nref=27 /ntot=56 /MaxReadThrough="5.75671" /MaxDrop="5.6153" /score="27.0133719" /energy="-14.7" /TU="U619" /idTUdmin="U619" /TUdmin="-2156" /isTUend="FALSE" /label="downshifts" promotor_-35 833266..833273 /Source="Nicolas_upshift_promotors" /id="U620" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.57942057942058" /psig=1 /xcortree=368 /SigmaFactorBS="ggcgcatggatataaggcgcctgcttttttatTGTTGAAAgc gctttattttTCCCCTACAATAGATGAAAAcggcgtgtaagggaggagcgatcaagga a" /listShort="acoR, sspH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 833286..833305 /Source="Nicolas_upshift_promotors" /id="U620" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.57942057942058" /psig=1 /xcortree=368 /SigmaFactorBS="ggcgcatggatataaggcgcctgcttttttatTGTTGAAAgc gctttattttTCCCCTACAATAGATGAAAAcggcgtgtaagggaggagcgatcaagga a" /listShort="acoR, sspH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 833294 /Source="Nicolas_upshifts" /id="U620" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.57942057942058" /psig=1 /xcortree=368 /SigmaFactorBS="ggcgcatggatataaggcgcctgcttttttatTGTTGAAAgc gctttattttTCCCCTACAATAGATGAAAAcggcgtgtaagggaggagcgatcaagga a" /listShort="acoR, sspH" /GFF_Attribute="listLong" /label="upshifts" CDS 833335..835152 /gene="acoR" /locus_tag="BSU_08100" /old_locus_tag="BSU08100" /experiment="publication(s) with functional evidences, PMID:11274109, 16944132" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11274109, 16944132; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (AcoR-acetoin)" /protein_id="NP_388691.1" /db_xref="EnsemblGenomes-Gn:BSU08100" /db_xref="EnsemblGenomes-Tr:CAB12639" /db_xref="GOA:O31551" /db_xref="InterPro:IPR002078" /db_xref="InterPro:IPR002197" /db_xref="InterPro:IPR003018" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR025944" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR029016" /db_xref="SubtiList:BG11790" /db_xref="UniProtKB/Swiss-Prot:O31551" /translation="MNSVPNDLQTWKRFVKDGVLDEARLRKRIAESWHRCKKAEVNPY LEKGPKVLQQTELDQQSKKHSFFLTTAKPYLEKLLPAIKEMEMMALLIDSDGVVLALD GHPRALYEAKRINFVEGACWTETAVGTNAIGTALHISEPVAIQGSEHYSIASHLWNCS AAPIHHEDGSLAGVIDISCPAAGAHPHMLGIATAIAYAAERELAAKSREKELELISRF GERAASSVPMVLCNTKQHIISASMPIRTSMPDWQGRHLYELKERGYSIENAVTIGDGG TCFYLSEQKKKKAFRFNGVIGQSGRSQAMLMHLERAAATDASVCLSGETGTGKEVAAR ALHENSERRHGPFVAVNCGAIPSDLIESELFGYAEGAFTGAKRNGYKGAFQKANQGTL FLDEIGEISHSMQVALLRVLQERKITPIGGTKEIPVDIRVIAATHCDLRELAENGKIR EDLFYRLHVYPIELPPLRDRTEDIPDLFEYYKQKNHWPGDLPSDFCNVLKQWKWPGNI RELFNVFERLSIRFPDGRLRDESLPALLEAAGLPASSAEKKPAAAGVLTFREQIQKDM MIKALESAKGNVSQAAKISGIPRSTFYKRLKKFNLSAES*" /label="acoR CDS" gene 833335..835152 /gene="acoR" /locus_tag="BSU_08100" /old_locus_tag="BSU08100" /label="acoR gene" promotor_-35 835153..835159 /Source="Nicolas_upshift_promotors" /id="U621" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=916 /SigmaFactorBS="tacaaacgcctgaaaaaattcaacttgtccgctgaatcataa AGCATACttccttcaggaaatGGAAACGTTATGtattgaaggagggtgttacgatgaa t" /listShort="sspH" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 835171 /Source="Nicolas_upshifts" /id="U621" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=916 /SigmaFactorBS="tacaaacgcctgaaaaaattcaacttgtccgctgaatcataa AGCATACttccttcaggaaatGGAAACGTTATGtattgaaggagggtgttacgatgaa t" /listShort="sspH" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 835174..835185 /Source="Nicolas_upshift_promotors" /id="U621" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=916 /SigmaFactorBS="tacaaacgcctgaaaaaattcaacttgtccgctgaatcataa AGCATACttccttcaggaaatGGAAACGTTATGtattgaaggagggtgttacgatgaa t" /listShort="sspH" /GFF_Attribute="listLong" /label="promotor_-10" CDS 835206..835385 /gene="sspH" /locus_tag="BSU_08110" /old_locus_tag="BSU08110" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10333516" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10333516; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="NP_388692.1" /db_xref="EnsemblGenomes-Gn:BSU08110" /db_xref="EnsemblGenomes-Tr:CAB12640" /db_xref="GOA:O31552" /db_xref="InterPro:IPR012610" /db_xref="SubtiList:BG12917" /db_xref="UniProtKB/Swiss-Prot:O31552" /translation="MNIQRAKEIVESPDMKKVTYNGVPIYIQHVNEETGTARIYPLDE PQEEHEVQLNSLKED*" /label="sspH CDS" gene 835206..835385 /gene="sspH" /locus_tag="BSU_08110" /old_locus_tag="BSU08110" /label="sspH gene" downshifts 835369 /Source="Nicolas_upshifts" /id="D407" /incds=0 /nref=96 /ntot=181 /MaxReadThrough="1.9176" /MaxDrop="6.06509" /score="5.08326573" /energy="-12" /TU="NA" /idTUdmin="U619" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(835421..835750) /gene="yfjF" /locus_tag="BSU_08120" /old_locus_tag="BSU08120" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="NP_388693.1" /db_xref="EnsemblGenomes-Gn:BSU08120" /db_xref="EnsemblGenomes-Tr:CAB12641" /db_xref="GOA:O31553" /db_xref="InterPro:IPR003844" /db_xref="SubtiList:BG12908" /db_xref="UniProtKB/Swiss-Prot:O31553" /translation="MMLITILLFLAAGLAEIGGGYLVWLWLREAKPAGYGIAGALILI VYGILPTFQSFPSFGRVYAAYGGVFIVLAVLWGWLVDRKTPDLYDWIGAFICLIGVCV ILFAPRG*" /label="yfjF CDS" gene complement(835421..835750) /gene="yfjF" /locus_tag="BSU_08120" /old_locus_tag="BSU08120" /label="yfjF gene" downshifts complement(835435) /Source="Nicolas_upshifts" /id="D408" /incds=0 /nref=96 /ntot=245 /MaxReadThrough="2.05328" /MaxDrop="6.2642" /score="34.1179702" /energy="-15.8" /TU="NA" /idTUdmin="U623" /TUdmin="-12" /isTUend="TRUE" /label="downshifts" CDS complement(835800..836258) /gene="yfjE" /locus_tag="BSU_08130" /old_locus_tag="BSU08130" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388694.1" /db_xref="EnsemblGenomes-Gn:BSU08130" /db_xref="EnsemblGenomes-Tr:CAB12642" /db_xref="GOA:O31554" /db_xref="InterPro:IPR035324" /db_xref="SubtiList:BG12907" /db_xref="UniProtKB/Swiss-Prot:O31554" /translation="MSEALTFESKYALLYLGGGLLAMIYGLITFFMAFPAFTSRGNVI FTIKTGPSGEIFLRKRSVLFSEVKRLYMGRHQYSLKGIFFEDIIIEKTDGKIVRIPTW NIITNPLFFEAVERYILPHLNEEAQNNWISQFTEVQRKAYLKEFENHPKL*" /label="yfjE CDS" gene complement(835800..836258) /gene="yfjE" /locus_tag="BSU_08130" /old_locus_tag="BSU08130" /label="yfjE gene" S_feature complement(836259..836351) /Source="Nicolas_S_feature" /locus_tag="new_886682_886774_c" /HighExp="BI, BC, S2, Sw, HiOs, HiTm, S5, ferm, S4, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S282" CDS complement(836352..836909) /gene="yfjD" /locus_tag="BSU_08140" /old_locus_tag="BSU08140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388695.1" /db_xref="EnsemblGenomes-Gn:BSU08140" /db_xref="EnsemblGenomes-Tr:CAB12643" /db_xref="GOA:O31555" /db_xref="InterPro:IPR035324" /db_xref="SubtiList:BG12906" /db_xref="UniProtKB/Swiss-Prot:O31555" /translation="MKNQEIIEVKSKMFLRIWAFVGSAGMGLACLWLFYMGITFQTKY YLLAIPAGFLFTLFCLYLFIIFFPAFTPRGNTIFRIKTGKNGEVFTDKVSVTFTDIKK IEMSRHKFSLKGIFQEDILIQTVDQKTIRIPTWNIIPNPLFFEAVERYILPHLNEEAK SNWIGQFTDIQRSAYLKEFENHPKL*" /label="yfjD CDS" gene complement(836352..836909) /gene="yfjD" /locus_tag="BSU_08140" /old_locus_tag="BSU08140" /label="yfjD gene" promotor_-35 836775..836780 /Source="Nicolas_upshift_promotors" /id="U622" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1171 /SigmaFactorBS="tataaacaaaacaaggtgaacagaaagccagcaggaatggct aatagGTAATAtttcgtttgaaacgTAATACCCATATAAAAGAGccacaaacatgcta a" /listShort="S283" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 836788 /Source="Nicolas_upshifts" /id="U622" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1171 /SigmaFactorBS="tataaacaaaacaaggtgaacagaaagccagcaggaatggct aatagGTAATAtttcgtttgaaacgTAATACCCATATAAAAGAGccacaaacatgcta a" /listShort="S283" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 836795..836813 /Source="Nicolas_upshift_promotors" /id="U622" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1171 /SigmaFactorBS="tataaacaaaacaaggtgaacagaaagccagcaggaatggct aatagGTAATAtttcgtttgaaacgTAATACCCATATAAAAGAGccacaaacatgcta a" /listShort="S283" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 836799..837386 /Source="Nicolas_S_feature" /locus_tag="new_887222_887809" /HighExp="S4, S5, S6, S3, S8, S7, LoTm, T5.0H, T4.0H, Pyr" /AntisenseName="yfjC" /AntisenseCor="9.3643586039105595E-2" /AntisenseRegPval="-0.9" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S283" CDS complement(836941..837708) /gene="yfjC" /locus_tag="BSU_08150" /old_locus_tag="BSU08150" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 14563871" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388696.1" /db_xref="EnsemblGenomes-Gn:BSU08150" /db_xref="EnsemblGenomes-Tr:CAB12644" /db_xref="SubtiList:BG12905" /db_xref="UniProtKB/Swiss-Prot:O31556" /translation="MKQFTISIEELLFCFYSEGFFEQGMALKQAYFPEIEDEQLGALF EAACRSLLAKDAAEYRNHQYRLKDEYCPFIHVLNDADYTVKLSKFNGQGAEQNVSCHV SKFGTYSHELLFDEQVHRITKMESSEGLLAKTDEFLHIIDTEDKRESIVTLTSNEFEK LLEGASDNPSYLKEFLEKHDHQEDVTRFANDLALRKGKMDTLMRLAYGKDNTPEVADM AFVLPGAHHTWLVTGITQNEFSILPAHKDVVNQIISK*" /label="yfjC CDS" gene complement(836941..837708) /gene="yfjC" /locus_tag="BSU_08150" /old_locus_tag="BSU08150" /label="yfjC gene" CDS complement(837720..838943) /gene="yfjB" /locus_tag="BSU_08160" /old_locus_tag="BSU08160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative phage protein" /protein_id="NP_388697.1" /db_xref="EnsemblGenomes-Gn:BSU08160" /db_xref="EnsemblGenomes-Tr:CAB12645" /db_xref="SubtiList:BG12904" /db_xref="UniProtKB/Swiss-Prot:O31557" /translation="MSGNIAVDPDKLEQLANDVVTELTDMENKYKDLHVELGQMILQC DPRYSSCFSGVGDAWSSGKALVTKLSDNEIFIRKTGDKFVEQDDILRKLYNAYDKYGT MTSLTALMLTQGKYYGLGLTKFVKQPSGLHTAQHSKLLLDISRAVDSSRYQKAARVLL NPKYLLKKTNRPFSDLVHKKFTKYFPQDTVDFSNSVRSYTKGFLNEAGVRSTLKDVGK TGLRFAKGNAITATLITGATETFGAGVKIAENYAKYQDKPEVLKRENAKAVGNAVNNT IFVAGGATAGAVIGGAIGSFAGPVGTVLLGAAGSYIGGVVGEQIAKYTAGFAEKAALK LKEPIHAVVDTAKKGLESAGKVVKSVNDGIDAANKSIHKGIDSAKKGMEKAKKTADSL IHGATHFLKGKFSFG*" /label="yfjB CDS" gene complement(837720..838943) /gene="yfjB" /locus_tag="BSU_08160" /old_locus_tag="BSU08160" /label="yfjB gene" CDS complement(838949..839263) /gene="yfjA" /locus_tag="BSU_08170" /old_locus_tag="BSU08170" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388698.1" /db_xref="EnsemblGenomes-Gn:BSU08170" /db_xref="EnsemblGenomes-Tr:CAB12646" /db_xref="InterPro:IPR010310" /db_xref="InterPro:IPR036689" /db_xref="SubtiList:BG12903" /db_xref="UniProtKB/Swiss-Prot:O31558" /translation="MDSYKVIELANKYSAAAEEVRSSKMLLESRLSALGDAWQGKARD SFDQDFEETKAAYDQFEQELLETSQELKAAAVKIEERKAEIARMEELERKAREERHKL GR*" /label="yfjA CDS" gene complement(838949..839263) /gene="yfjA" /locus_tag="BSU_08170" /old_locus_tag="BSU08170" /label="yfjA gene" promotor_-10 complement(839311..839330) /Source="Nicolas_upshift_promotors" /id="U623" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.852147852147852" /psig="0.992007992007992" /xcortree=2761 /SigmaFactorBS="cgcccttccaattcttatgaaaaggttcttttgtacGATTcg gatacatgccgaATTATTTATAATCATTTATAtaaaacatccaattgtgcgtgaattt a" /listShort="yfjA, yfjB, yfjC, yfjD, S282, yfjE, yfjF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(839324) /Source="Nicolas_upshifts" /id="U623" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.852147852147852" /psig="0.992007992007992" /xcortree=2761 /SigmaFactorBS="cgcccttccaattcttatgaaaaggttcttttgtacGATTcg gatacatgccgaATTATTTATAATCATTTATAtaaaacatccaattgtgcgtgaattt a" /listShort="yfjA, yfjB, yfjC, yfjD, S282, yfjE, yfjF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(839345..839348) /Source="Nicolas_upshift_promotors" /id="U623" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.852147852147852" /psig="0.992007992007992" /xcortree=2761 /SigmaFactorBS="cgcccttccaattcttatgaaaaggttcttttgtacGATTcg gatacatgccgaATTATTTATAATCATTTATAtaaaacatccaattgtgcgtgaattt a" /listShort="yfjA, yfjB, yfjC, yfjD, S282, yfjE, yfjF" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 839555..839574 /Source="Nicolas_upshift_promotors" /id="U624" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.258741258741259" /psig="0.684315684315684" /xcortree=342 /SigmaFactorBS="cactaaagttgatcaaatgacctaagtgcgccaaacgtgtta cgggacgagctatctCATGGTATAAATGGAATTGTaaacgttatcaaggaggtcgtca t" /listShort="malA, malR, malP, malQ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 839558 /Source="Nicolas_upshifts" /id="U624" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.258741258741259" /psig="0.684315684315684" /xcortree=342 /SigmaFactorBS="cactaaagttgatcaaatgacctaagtgcgccaaacgtgtta cgggacgagctatctCATGGTATAAATGGAATTGTaaacgttatcaaggaggtcgtca t" /listShort="malA, malR, malP, malQ" /GFF_Attribute="listLong" /label="upshifts" CDS 839599..840948 /gene="malA" /locus_tag="BSU_08180" /old_locus_tag="BSU08180" /EC_number="3.2.1.122" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9765262, 10329789, 11489864, 15341727, 15670594, 16707683, 17676871, 20698522" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9765262, 10329789, 11489864, 15341727, 15670594, 16707683, 17676871, 20698522; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="6-phospho-alpha-glucosidase" /protein_id="NP_388699.1" /db_xref="EnsemblGenomes-Gn:BSU08180" /db_xref="EnsemblGenomes-Tr:CAB12647" /db_xref="GOA:P54716" /db_xref="InterPro:IPR001088" /db_xref="InterPro:IPR015955" /db_xref="InterPro:IPR019802" /db_xref="InterPro:IPR022616" /db_xref="InterPro:IPR036291" /db_xref="PDB:1U8X" /db_xref="SubtiList:BG11839" /db_xref="UniProtKB/Swiss-Prot:P54716" /translation="MKKKSFSIVIAGGGSTFTPGIVLMLLDHLEEFPIRKLKLYDNDK ERQDRIAGACDVFIREKAPDIEFAATTDPEEAFTDVDFVMAHIRVGKYAMRALDEQIP LKYGVVGQETCGPGGIAYGMRSIGGVLEILDYMEKYSPDAWMLNYSNPAAIVAEATRR LRPNSKILNICDMPVGIEDRMAQILGLSSRKEMKVRYYGLNHFGWWTSIQDQEGNDLM PKLKEHVSQYGYIPKTEAEAVEASWNDTFAKARDVQAADPDTLPNTYLQYYLFPDDMV KKSNPNHTRANEVMEGREAFIFSQCDMITREQSSENSEIKIDDHASYIVDLARAIAYN TGERMLLIVENNGAIANFDPTAMVEVPCIVGSNGPEPITVGTIPQFQKGLMEQQVSVE KLTVEAWAEKSFQKLWQALILSKTVPNARVARLILEDLVEANKDFWPELDQSPTRIS* " /label="malA CDS" gene 839599..840948 /gene="malA" /locus_tag="BSU_08180" /old_locus_tag="BSU08180" /label="malA gene" misc_feature 840977..840996 /Source="Nicolas_upshift_promotors" /id="U625" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=3083 /SigmaFactorBS="cttgatcaaagcccaacccgcatatcataaatgaaattcccc cattttcgaatctgtaATTGTATATAATAGAAAGAAaatggggggatctgatatgcag c" /listShort="malR, malP" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 840979 /Source="Nicolas_upshifts" /id="U625" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=3083 /SigmaFactorBS="cttgatcaaagcccaacccgcatatcataaatgaaattcccc cattttcgaatctgtaATTGTATATAATAGAAAGAAaatggggggatctgatatgcag c" /listShort="malR, malP" /GFF_Attribute="listLong" /label="upshifts" CDS 841013..841777 /gene="malR" /locus_tag="BSU_08190" /old_locus_tag="BSU08190" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11489864, 16707683, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11489864, 16707683, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional activator of the Mal operon" /protein_id="NP_388700.1" /db_xref="EnsemblGenomes-Gn:BSU08190" /db_xref="EnsemblGenomes-Tr:CAB12648" /db_xref="GOA:P54717" /db_xref="InterPro:IPR000281" /db_xref="InterPro:IPR001347" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR035472" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11847" /db_xref="UniProtKB/Swiss-Prot:P54717" /translation="MQLEELINQHYSKLNDNDFHILKYILNHKHTCYHLGIDALAKAC SVSRSSILRLAQKLGFSGYSEFRVFLKWEDQPEEGESMSFEKLLDDIEANLKFLRTKD MTDMCQLIDAADRIFVYGSGNAQKICARDLQRMFIPRHRYLILIEDTNEFNLMRDDFK VNDLFIIISLSGETPELIPQARMLSAKGIPFISITNLKNNVLAQLTPHNLYATSKPVT LSDRTEIVAFAPFFLVGEALFRAYVDYKEAEKNDNE*" /label="malR CDS" gene 841013..841777 /gene="malR" /locus_tag="BSU_08190" /old_locus_tag="BSU08190" /label="malR gene" promotor_-10 complement(841157..841171) /Source="Nicolas_upshift_promotors" /id="U626" /multdbtbs="-" /comp="M9" /sig="Sig-" /pcomp="0.454545454545455" /psig="0.454545454545455" /xcortree=655 /SigmaFactorBS="cttcttccggctgatcttcccactttaaaaagacgcgaaatt cactgtaaccgcTGAAACCgagcttttgggcaagCCGTAAAATTGAGGAacgcgatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(841187..841193) /Source="Nicolas_upshift_promotors" /id="U626" /multdbtbs="-" /comp="M9" /sig="Sig-" /pcomp="0.454545454545455" /psig="0.454545454545455" /xcortree=655 /SigmaFactorBS="cttcttccggctgatcttcccactttaaaaagacgcgaaatt cactgtaaccgcTGAAACCgagcttttgggcaagCCGTAAAATTGAGGAacgcgatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(841187) /Source="Nicolas_upshifts" /id="U626" /multdbtbs="-" /comp="M9" /sig="Sig-" /pcomp="0.454545454545455" /psig="0.454545454545455" /xcortree=655 /SigmaFactorBS="cttcttccggctgatcttcccactttaaaaagacgcgaaatt cactgtaaccgcTGAAACCgagcttttgggcaagCCGTAAAATTGAGGAacgcgatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 841792..843375 /gene="malP" /locus_tag="BSU_08200" /old_locus_tag="BSU08200" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16707683, 16850406, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16707683, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) maltose-specificenzyme IICB component" /protein_id="NP_388701.1" /db_xref="EnsemblGenomes-Gn:BSU08200" /db_xref="EnsemblGenomes-Tr:CAB12649" /db_xref="GOA:P54715" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR004719" /db_xref="InterPro:IPR010975" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="SubtiList:BG11848" /db_xref="UniProtKB/Swiss-Prot:P54715" /translation="MMQKIQRFGSAMFVPVLLFAFAGIIVGISTLFKNKTLMGPLADP DGFWYQCWYIIEQGGWTVFNQMPLLFAIGIPVALAKKAQARACLEALTVYLTFNYFVS AILTVWGGAFGVDMNQEVGGTSGLTMIAGIKTLDTNIIGAIFISSIVVFLHNRYFDKK LPDFLGIFQGSTYIVMISFFIMIPIALAVSYIWPMVQSGIGSLQSFLVASGAVGVWIY TFLERILIPTGLHHFIYTPFIYGPAVAEGGIVTYWAQHLGEYSQSAKPLKELFPQGGF ALHGNSKIFGIPGIALAFYVTAKKEKKKLVAGLLIPVTLTAIVAGITEPIEFTFLFIS PFLFAVHAVLAATMSTVMYMAGVVGNMGGGLIEAVTLNWIPLFGSHGMTYVYQILIGL SFTAIYFFVFRFLILKFNIATPGREKDEQQETKLYSKKEYRERKNKDETASAAETADD TAFLYIEALGGKDNITEVTNCATRLRVSVKDETKVEPDSVFRALGAHGVVRNGKAFQV IIGLSVPQMRERVEKILNQ*" /label="malP CDS" gene 841792..843375 /gene="malP" /locus_tag="BSU_08200" /old_locus_tag="BSU08200" /label="malP gene" downshifts 843355 /Source="Nicolas_upshifts" /id="D409" /incds=0 /nref=23 /ntot=46 /MaxReadThrough="3.26652" /MaxDrop="4.69656" /score="8.65399085" /energy="-10.9" /TU="U624" /idTUdmin="U625" /TUdmin=836 /isTUend="FALSE" /label="downshifts" promotor_-35 843404..843411 /Source="Nicolas_upshift_promotors" /id="U627" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2032 /SigmaFactorBS="aaagactgccctccttttcgggagggttttCGTTTGCCgtca aaaagaccgcCATAGTAAAGTAAAGAAAGAgacaatcgagtaaaaaggggtttggagg c" /listShort="malQ, yfiC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 843426..843445 /Source="Nicolas_upshift_promotors" /id="U627" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2032 /SigmaFactorBS="aaagactgccctccttttcgggagggttttCGTTTGCCgtca aaaagaccgcCATAGTAAAGTAAAGAAAGAgacaatcgagtaaaaaggggtttggagg c" /listShort="malQ, yfiC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 843434 /Source="Nicolas_upshifts" /id="U627" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2032 /SigmaFactorBS="aaagactgccctccttttcgggagggttttCGTTTGCCgtca aaaagaccgcCATAGTAAAGTAAAGAAAGAgacaatcgagtaaaaaggggtttggagg c" /listShort="malQ, yfiC" /GFF_Attribute="listLong" /label="upshifts" CDS 843481..845202 /gene="yfiB" /locus_tag="BSU_08210" /old_locus_tag="BSU08210" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16707683; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative xenobiotic ABC transporter subunit (ATP-binding protein)" /protein_id="NP_388702.1" /db_xref="EnsemblGenomes-Gn:BSU08210" /db_xref="EnsemblGenomes-Tr:CAB12650" /db_xref="GOA:P54718" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG11849" /db_xref="UniProtKB/Swiss-Prot:P54718" /translation="MQKALSFLKPYSLLAGIALILMLTELAVELMQPLLIAKIIDDGI LKQDLRHVWIWGTVMIGLTVLSFAAGMLNSFYAAHVSQSFSYDTRKGLFQKIQSFSYS TFGQFSSSSYITRLTNDVTQVQNMIFMSLRFMLRAPLMIAGGIVLSLAVNVKLGFFLL VTIPILILFLLWVLRKGGALFRSVQKRLDQVNTIMQENLIAIKLIKALLRGSHEVKRF IKANTRLMEKTVSAFQLVEFTMPVLMLLMNLCILLILWAGSYSITSGSTQVGDVVAII NYATRITGALSMFPFLIMIFTRAKASGDRIGEVLETEGDEREEGTISDRLSGRIEFQH VSFRYPEMDREALRNVSFSAKPRETIAILGATGSGKSTLFQLIPRLYQPDSGRIYIDE KPVQDIPAEGLRRQIGYVPQEVLLFSGTIKENIAWGKENASLDEIMDAAKLAQIHETI LKLPNGYDTVLGQRGVNLSGGQKQRISIARALIRKPAILLLDDSTSALDLQTEAKLLE AISTYHCTTLIITQKITTAMKADQILLLEDGELIEKGTHSELLSESQLYKRIYESQFG REGSESC*" /label="yfiB CDS" gene 843481..845202 /gene="yfiB" /locus_tag="BSU_08210" /old_locus_tag="BSU08210" /label="yfiB gene" CDS 845196..847010 /gene="yfiC" /locus_tag="BSU_08220" /old_locus_tag="BSU08220" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_388703.1" /db_xref="EnsemblGenomes-Gn:BSU08220" /db_xref="EnsemblGenomes-Tr:CAB12651" /db_xref="GOA:P54719" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG11850" /db_xref="UniProtKB/Swiss-Prot:P54719" /translation="MLKDIRKPFQYPKLPIDKKEGAKKRAKAKDTKGTLRRIWSYLAE RKGLLILVMLMVVISAIFGLLGPFVIGKAIDHFIVGKTVSGLIPVLLLLLAIYIIQSL SLWFQNYWMITISQGTVFRMRSELFTHLHELPIPFFDKQRHGELMSRVTNDIENVSST LNTSVIQILSSVITFVGTIAVMLYMSPLLTLITLTIIPVMAASLKWITNRTGKLFKEQ QKNLGDLNGYIEESVSGAKVIKAYSREKQITAEFLEKNAALKTSGFWAQTISGFIPKV MNSLNNLSFTMIAAIGGLFALKGWISIGSIVVFAEYSRQFTRPLNDLANQFNTMLSAI AGAERVFDVLDEKEEREDEKNAVHQPIQTGSIEFRDVSFGYDKGQQTLKHLQFTVPAG QSIAFVGPTGAGKTTVTNLLARFYEPNDGKILIDGTDIKTLTRASLRKNMGFVLQDSF LFQGTIRENIRYGRLDASDQEVEAAAKTANAHSFIERLPKGYDTVLTQNGSGISQGQK QLISIARAVLADPVLLILDEATSNIDTVTEVNIQEALARLMEGRTSVIIAHRLNTIQR ADQIVVLKNGEMIEKGSHDELIRQKGFYSDLYESQFEK*" /label="yfiC CDS" gene 845196..847010 /gene="yfiC" /locus_tag="BSU_08220" /old_locus_tag="BSU08220" /label="yfiC gene" downshifts 846985 /Source="Nicolas_upshifts" /id="D410" /incds=0 /nref=103 /ntot=190 /MaxReadThrough="2.4559" /MaxDrop="5.61906" /score="24.4395842" /energy="-11" /TU="NA" /idTUdmin="U627" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 847092..847099 /Source="Nicolas_upshift_promotors" /id="U628" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.75024975024975" /psig=1 /xcortree=1845 /SigmaFactorBS="cttttatttcattttcgtaaaatgtaacaaaattaCTTGACG TaaacaagttatgtATATATACTAGCTTACATTAagtaagtgataacatttatcaagg a" /listShort="catD, catE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 847113..847132 /Source="Nicolas_upshift_promotors" /id="U628" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.75024975024975" /psig=1 /xcortree=1845 /SigmaFactorBS="cttttatttcattttcgtaaaatgtaacaaaattaCTTGACG TaaacaagttatgtATATATACTAGCTTACATTAagtaagtgataacatttatcaagg a" /listShort="catD, catE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 847117 /Source="Nicolas_upshifts" /id="U628" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.75024975024975" /psig=1 /xcortree=1845 /SigmaFactorBS="cttttatttcattttcgtaaaatgtaacaaaattaCTTGACG TaaacaagttatgtATATATACTAGCTTACATTAagtaagtgataacatttatcaagg a" /listShort="catD, catE" /GFF_Attribute="listLong" /label="upshifts" CDS 847165..847569 /gene="catD" /locus_tag="BSU_08230" /old_locus_tag="BSU08230" /EC_number="1.13.11.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15849754, 16872404, 16850406, 17407181, 20639328" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16872404, 16850406, 17407181, 20639328; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="catechol-2,3-dioxygenase membrane subunit" /protein_id="NP_388704.1" /db_xref="EnsemblGenomes-Gn:BSU08230" /db_xref="EnsemblGenomes-Tr:CAB12652" /db_xref="GOA:P54720" /db_xref="InterPro:IPR032808" /db_xref="SubtiList:BG11851" /db_xref="UniProtKB/Swiss-Prot:P54720" /translation="MNKSFEIGTLLLRVITGIIFFVHGLSKFQGMEGTIQFFGSIGLP SFMAYVIAAIELIGGVLVFFGLATRIVGVLFALTLIGAIITVKLKAPFMGNAEFDYLL LLTSIHLALTGSRFLALDPFVFKGKKNGNVSA*" /label="catD CDS" gene 847165..847569 /gene="catD" /locus_tag="BSU_08230" /old_locus_tag="BSU08230" /label="catD gene" CDS 847587..848444 /gene="catE" /locus_tag="BSU_08240" /old_locus_tag="BSU08240" /EC_number="1.13.11.2" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:17407181, 16872404" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17407181, 16872404; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="catechol-2,3-dioxygenase subunit" /protein_id="NP_388705.2" /db_xref="EnsemblGenomes-Gn:BSU08240" /db_xref="EnsemblGenomes-Tr:CAB12653" /db_xref="GOA:P54721" /db_xref="InterPro:IPR000486" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG11852" /db_xref="UniProtKB/Swiss-Prot:P54721" /translation="MTSIHEDTHIGYAKLTIRSLERSLQFYCNVIGFQVLKKTDRQAE LTADGKRVLLILEENPSAVVLPERSVTGLYHFAILLPDRKELGIALARLIEHGIAIGH GDHAVSEALYLSDPDGNGIEMYADRPRSTWQRDREGNYVMTTTAVDIEGLLEEAGDER KTSLPNDTIIGHIHLHVSDLKEAKAFYTDVLGFDIVGNYAGMSALFVSAGGYHHHIGL NIWAGRNAPPKPTNASGLDYYTVVLPHQEELDLVANRVKHAGYSIEETENSFRVKDPV SGAYITFVI*" /label="catE CDS" gene 847587..848444 /gene="catE" /locus_tag="BSU_08240" /old_locus_tag="BSU08240" /label="catE gene" downshifts 848431 /Source="Nicolas_upshifts" /id="D411" /incds=0 /nref=4 /ntot=21 /MaxReadThrough="0.66359" /MaxDrop="3.74886" /score="50.8573531" /energy="-19.7" /TU="NA" /idTUdmin="U628" /TUdmin=16 /isTUend="TRUE" /label="downshifts" CDS 848538..849482 /gene="yfiF" /locus_tag="BSU_08250" /old_locus_tag="BSU08250" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10704478; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (AraC/XylS family; cupin family)" /protein_id="NP_388706.1" /db_xref="EnsemblGenomes-Gn:BSU08250" /db_xref="EnsemblGenomes-Tr:CAB12654" /db_xref="GOA:P54722" /db_xref="InterPro:IPR003313" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR018060" /db_xref="InterPro:IPR018062" /db_xref="SubtiList:BG11853" /db_xref="UniProtKB/Swiss-Prot:P54722" /translation="MELNHLVTGKIALNQYVHRLEQKDVSFYVHYWGAMTNHYNTLLH KHSFYEICYVVRGEGYYLEGDRTYPLREQTIFLSKPEHLHQIKSETGLFLFYVAFELS EDQSSAEWIKVMEEVKQSPFITMQLKDGEPPGLLWKTLMLQAAQPVNAFDKEILSHLS HALILSLIQTFLPYAQRPKQKQPIHTSSALLTEVKLHIKDNLSQPLKLTDVASHFHIS GRHLSRLFAAELGVSYSEFVQNEKINKAAELLKSTNLSIKEIAEEIGFSVHYFTRVFS AKIGSSPGLFRSLYKDSKMTAFQINKPFQKIEQAKPHE*" /label="yfiF CDS" gene 848538..849482 /gene="yfiF" /locus_tag="BSU_08250" /old_locus_tag="BSU08250" /label="yfiF gene" downshifts complement(849349) /Source="Nicolas_upshifts" /id="D412" /incds=1 /nref=1 /ntot=2 /MaxReadThrough="-0.20031" /MaxDrop="3.51831" /score="-4.19869956" /energy="-9.5" /TU="NA" /idTUdmin="U632" /TUdmin=9372 /isTUend="FALSE" /label="downshifts" promotor_no_box complement(849397..849497) /Source="Nicolas_upshift_promotors" /id="U629" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.533466533466533" /psig="0.034965034965035" /xcortree=1481 /SigmaFactorBS="tcatttcaggacatcttattcgtgcggcttggcctgttcgat tttttgaaaaggtttattgatttgaaatgcggtcatttttgagtctttataaagggag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(849437) /Source="Nicolas_upshifts" /id="U629" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.533466533466533" /psig="0.034965034965035" /xcortree=1481 /SigmaFactorBS="tcatttcaggacatcttattcgtgcggcttggcctgttcgat tttttgaaaaggtttattgatttgaaatgcggtcatttttgagtctttataaagggag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 849657..851105 /gene="yfiG" /locus_tag="BSU_08260" /old_locus_tag="BSU08260" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative sugar/proton transporter" /protein_id="NP_388707.1" /db_xref="EnsemblGenomes-Gn:BSU08260" /db_xref="EnsemblGenomes-Tr:CAB12655" /db_xref="GOA:P54723" /db_xref="InterPro:IPR003663" /db_xref="InterPro:IPR005828" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11854" /db_xref="UniProtKB/Swiss-Prot:P54723" /translation="MSTKKKEAVIGKESLAHKGLLRTITLVSTFGGLLFGYDTGVING ALPFMATAGQLNLTPVTEGLVASSLLLGAAFGAMFGGRLSDRHGRRKTILYLALLFIA ATLGCTFSPNASVMIAFRFLLGLAVGCASVTVPTFLAEISPAERRGRIVTQNELMIVI GQLLAYTFNAIIGSTMGESANVWRYMLVIATLPAVVLWFGMLIVPESPRWLAAKGRMG DALRVLRQIREDSQAQQEIKEIKHAIEGTAKKAGFHDFQEPWIRRILFIGIGIAIVQQ ITGVNSIMYYGTEILREAGFQTEAALIGNIANGVISVIAVIFGIWLLGKVRRRPMLII GQIGTMTALLLIGILSIVLEGTPALPYVVLSLTILFLAFQQTAISTVTWLMLSEIFPM HVRGLGMGISTFCLWTANFLIGFTFPILLNHIGMSATFFIFVAMNILAILFVKKYVPE TKGRSLEQLEHSFRQYGRRADQEIQNQTTHLS*" /label="yfiG CDS" gene 849657..851105 /gene="yfiG" /locus_tag="BSU_08260" /old_locus_tag="BSU08260" /label="yfiG gene" CDS 851132..852073 /gene="yfiH" /locus_tag="BSU_08270" /old_locus_tag="BSU08270" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sugar-phosphate epimerase/isomerase" /protein_id="NP_388708.1" /db_xref="EnsemblGenomes-Gn:BSU08270" /db_xref="EnsemblGenomes-Tr:CAB12656" /db_xref="InterPro:IPR011418" /db_xref="InterPro:IPR013022" /db_xref="InterPro:IPR036237" /db_xref="SubtiList:BG11855" /db_xref="UniProtKB/Swiss-Prot:P54724" /translation="MKLSYVTDSLGHLPFEDMLNFAAKLGIDTLEMTTGGWSPAPHLN LDELLQSSEKRKEFSQALEKRNMTLCALNCSGNPLDPGELGKSHRDITDKTMELAGLL GVKKVIMMSGLPAGGPDDKVPNWITYTVSWPPVLKDILNYQWEDVAIPYWKKLVKKAE ACGVGKIALENFSSQLVYNPETLFRLRNAVGPMVGLNLDPSHLLWMGADPIIAARELG SAIHHVHGKDVRIERYLSAVNGLLETKEVTDPANRAWNYVAVGCGQDLQWWKEFFSVV KMMGYEGEVSLEMEDLTMSPEAGIRTSVEALKQTISQ*" /label="yfiH CDS" gene 851132..852073 /gene="yfiH" /locus_tag="BSU_08270" /old_locus_tag="BSU08270" /label="yfiH gene" CDS 852083..853264 /gene="yfiI" /locus_tag="BSU_08280" /old_locus_tag="BSU08280" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 26438878; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388709.1" /db_xref="EnsemblGenomes-Gn:BSU08280" /db_xref="EnsemblGenomes-Tr:CAB12657" /db_xref="GOA:P94437" /db_xref="InterPro:IPR000683" /db_xref="InterPro:IPR004104" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12214" /db_xref="UniProtKB/Swiss-Prot:P94437" /translation="MMLNGERIISKPLRWAMVGGGRLSQVGYKHRIGALRDNTAFQLT AGAFDIDAERGKDFGVNLGVDAERCYPNYQTMFAEEAKRQDGIEVVSIATPNGTHYEI CKAALEAGVHVICEKPLFFTSAEGQEIKALAEKKGKIVGVTYGFSGNQMLLQMRAMIE QGMIGDIRVVDLQYTHGFCATDEGEKISAAQKWRVDPAIAGPSFVLGDLSTHTYYMSQ LIMPKMKIKELLCDRQSFVGSRAPLEDNAHVLMHYENGAVGTMWTSSINAGCMDGHRI RIVGSKASIEWWDSKPNELTYEVQGEPGQTLVRGMPYLDDVCNADERLGALHSEGLSE AWANIYLKFAIAIDAKNREDEEILNNLVYPDIDAGIEGIRWIENCVRSANQGSVWVEF K*" /label="yfiI CDS" gene 852083..853264 /gene="yfiI" /locus_tag="BSU_08280" /old_locus_tag="BSU08280" /label="yfiI gene" downshifts 853254 /Source="Nicolas_upshifts" /id="D413" /incds=0 /nref=40 /ntot=113 /MaxReadThrough="0.88387" /MaxDrop="5.80704" /score="14.819468" /energy="-13" /TU="NA" /idTUdmin="U630" /TUdmin="-2003" /isTUend="FALSE" /label="downshifts" promotor_-35 853324..853330 /Source="Nicolas_upshift_promotors" /id="U630" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.517482517482518" /psig="0.918081918081918" /xcortree=2137 /SigmaFactorBS="cggtttttattttccagaaacTCCTGTCaaaaatgccctgag GCAGGTATGATAAGAAGGGAattgggtatcgggagtgatgagcgtgaaagctcttttt t" /listShort="yfiJ, yfiK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 853345..853364 /Source="Nicolas_upshift_promotors" /id="U630" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.517482517482518" /psig="0.918081918081918" /xcortree=2137 /SigmaFactorBS="cggtttttattttccagaaacTCCTGTCaaaaatgccctgag GCAGGTATGATAAGAAGGGAattgggtatcgggagtgatgagcgtgaaagctcttttt t" /listShort="yfiJ, yfiK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 853363 /Source="Nicolas_upshifts" /id="U630" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.517482517482518" /psig="0.918081918081918" /xcortree=2137 /SigmaFactorBS="cggtttttattttccagaaacTCCTGTCaaaaatgccctgag GCAGGTATGATAAGAAGGGAattgggtatcgggagtgatgagcgtgaaagctcttttt t" /listShort="yfiJ, yfiK" /GFF_Attribute="listLong" /label="upshifts" CDS 853388..854590 /gene="linJ" /locus_tag="BSU_08290" /old_locus_tag="BSU08290" /function="16.12: Sense" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:11717295, 12618459, 28461449" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 12618459, 28461449; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [LinK] (linearmycin resistance, biofilm formation)" /protein_id="NP_388710.1" /db_xref="EnsemblGenomes-Gn:BSU08290" /db_xref="EnsemblGenomes-Tr:CAB12658" /db_xref="GOA:P94438" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12215" /db_xref="UniProtKB/Swiss-Prot:P94438" /translation="MKALFFTRMFTLMVSCLMYLSIVKEDNWFGYVFIAAGAAMYAAN HVLLTKETNAIWFCLIDIAIGFSFGFIFPGTGLFIIMLCPVAVAFFLRGFPKRTAWSV LCLSSILFLTVLIRTYAMFGNEFVIDHLTSMTFVVFCGVVGKLIRKLLDAQDTAKQQF QELTESHLALSAAHQELHLYAKQVEELTAIYERNRMAREIHDTVGHKMTALLVQLQLL REWQKRDSQKADETVGVCETLAREALDDVRLSVRTLQTENDPSLIESLKQLTEDFCKN AGVTTEFAVSGDPAIIPLSLHPTLIRTVQEALTNAKRHGGAAACSIQLACTTDSISLV IKDDGKGNPEAALGFGLLNMKKRAAEHGGMIRFESERDQGFTVNAEFSLANKKWSFGP VQQKESLS*" /label="linJ CDS" gene 853388..854590 /gene="linJ" /locus_tag="BSU_08290" /old_locus_tag="BSU08290" /label="linJ gene" CDS 854587..855249 /gene="linK" /locus_tag="BSU_08300" /old_locus_tag="BSU08300" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 12618459, 28461449" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 12618459, 28461449; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [LinJ] (linearmycin resistance, biofilm formation)" /protein_id="NP_388711.1" /db_xref="EnsemblGenomes-Gn:BSU08300" /db_xref="EnsemblGenomes-Tr:CAB12659" /db_xref="GOA:P94439" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12216" /db_xref="UniProtKB/Swiss-Prot:P94439" /translation="MIKIIITDDQDIVREGLASLLQLREELDVIATARNGQEAFEKAK ELEPDIVLMDIRMPVSNGVEGTKLITSSLPSVKVLMLTTFKDSALIAEALEEGASGYL LKDMSADTIVKAVMTVHSGGMVLPPELTAQMLNEWKREKQLKGINEIEKPNELLDLTE REIEVLAELGYGLNNKEIAEKLYITEGTVKNHVSNIISKLAVRDRTQAAIYSVRYGVS VF*" /label="linK CDS" gene 854587..855249 /gene="linK" /locus_tag="BSU_08300" /old_locus_tag="BSU08300" /label="linK gene" downshifts 855257 /Source="Nicolas_upshifts" /id="D414" /incds=0 /nref=114 /ntot=229 /MaxReadThrough="-0.0105699999999995" /MaxDrop="4.23231" /score="20.4785449" /energy="-7.6" /TU="NA" /idTUdmin="U630" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 855393..856328 /gene="bifL" /locus_tag="BSU_08310" /old_locus_tag="BSU08310" /function="16.8: Protect" /function="16.13: Shape" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:28461449" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 28461449; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (ATP-binding protein) biofilm formation" /protein_id="NP_388712.2" /db_xref="EnsemblGenomes-Gn:BSU08310" /db_xref="EnsemblGenomes-Tr:CAB12660" /db_xref="GOA:P94440" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12217" /db_xref="UniProtKB/Swiss-Prot:P94440" /translation="MLQAENIKKAYGKKTIVKGISFSLKKGESFGLLGPNGAGKSTTI SMISGLVPHDSGNITVGGYVIGKETAKAKQKIGIVPQEIALYPTLTAHENLMFWGKMY GLTHGEAKKRAAEVLEYVGLTERAKDKIETFSGGMKRRINIGAALMHKPELLIMDEPT VGIDPQSRNHILETVKQLNETGMTVIYTSHYMEEVEFLCDRIGIIDQGEMIAIGTKTD LCSRLGGDTIIQLTVSGINEAFLVAIRSLAHVNDVTVHELELKIDISAAHHEKVVTSL LAEATAHHINLLSLQVQEPNLERLFLNLTGRTLRD*" /label="bifL CDS" gene 855393..856328 /gene="bifL" /locus_tag="BSU_08310" /old_locus_tag="BSU08310" /label="bifL gene" CDS 856341..857531 /gene="bifM" /locus_tag="BSU_08320" /old_locus_tag="BSU08320" /function="16.8: Protect" /function="16.13: Shape" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 28461449" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 28461449; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (permease) biofilm formation" /protein_id="NP_388713.1" /db_xref="EnsemblGenomes-Gn:BSU08320" /db_xref="EnsemblGenomes-Tr:CAB12661" /db_xref="GOA:P94441" /db_xref="InterPro:IPR000412" /db_xref="SubtiList:BG12218" /db_xref="UniProtKB/Swiss-Prot:P94441" /translation="MKKSIWIAWKDVKIRITDRKGFMMLILMPLILTCILGAALGSVV DGGSRIDDIKVGYIQSDQSDTANMFTKDVLKKMKSIKVTKVGSKDKMKKLIDEKKIDV GIVIPNHWEAGKTSAVVNAAPDQTLKSSIIETAASSFIEQYKAVKEAASGSMDYISKT EAVKQGKLDPAQFAEKLAKTLEKETGDKLTIAEKSVGSKAVTSFQYYSAAMLCMFMLF HITVGAKSFLQEKDTETLARMLMTPAQKSVILFGKWLGTYLFAIIQFFIFLIVTINVF GVDWGGNLLLVSVLGLSYAAAVSGISMLLASCISDMKTADAIGGFGIQLLAVLGGSML PLYQFPDVLQSVSKAVPNRWALDGFLSLMEGGGWADLQKPVLLFAAIGFCSLVIGIRR LHTR*" /label="bifM CDS" gene 856341..857531 /gene="bifM" /locus_tag="BSU_08320" /old_locus_tag="BSU08320" /label="bifM gene" CDS 857545..858702 /gene="bifN" /locus_tag="BSU_08330" /old_locus_tag="BSU08330" /function="16.8: Protect" /function="16.13: Shape" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 28461449" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 28461449; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (permease) biofilm formation" /protein_id="NP_388714.1" /db_xref="EnsemblGenomes-Gn:BSU08330" /db_xref="EnsemblGenomes-Tr:CAB12662" /db_xref="GOA:P94442" /db_xref="InterPro:IPR000412" /db_xref="SubtiList:BG12219" /db_xref="UniProtKB/Swiss-Prot:P94442" /translation="MKKILAICGIELSLIFKKPQNYLIMFAAPLLLTFVFGSMLSGND DKVRLAIVDQDDTILSQHYIRQLKAHDDMYVFENMSESKASEKLKQKKIAGIIVISRS FQTQLEKGKHPELIFRHGPELSEAPMVKQYAESALATLNIQVTAAKTASQTAGENWKA AYKTVFAKKHEDIVPAVTRQTLSDKKEGAEASDTASRAAGFSILFVMLTMMGAAGTIL EARKNGVWSRLLTASVSRAEIGAGYVLSFFVIGWIQFGILLLSTHWLFGINWGNPAAV IVLVSLFLLTVVGIGLMIAANVRTPEQQLAFGNLFVIATCMVSGMYWPIDIEPKFMQS IAEFLPQKWAMSGLTEIIANGARVTDILGICGILLAFAAITFAAGLKALRA*" /label="bifN CDS" gene 857545..858702 /gene="bifN" /locus_tag="BSU_08330" /old_locus_tag="BSU08330" /label="bifN gene" promotor_-35 857656..857661 /Source="Nicolas_upshift_promotors" /id="U631" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.693306693306693" /psig="0.693306693306693" /xcortree=1182 /SigmaFactorBS="atgtttgctgccccgcttttgcttacctttgtatttgggAGT ATGctcagcggcaatgaTGATAAGGTGCGGCTTGCAatcgttgatcaggacgatacga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 857676..857694 /Source="Nicolas_upshift_promotors" /id="U631" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.693306693306693" /psig="0.693306693306693" /xcortree=1182 /SigmaFactorBS="atgtttgctgccccgcttttgcttacctttgtatttgggAGT ATGctcagcggcaatgaTGATAAGGTGCGGCTTGCAatcgttgatcaggacgatacga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 857677 /Source="Nicolas_upshifts" /id="U631" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.693306693306693" /psig="0.693306693306693" /xcortree=1182 /SigmaFactorBS="atgtttgctgccccgcttttgcttacctttgtatttgggAGT ATGctcagcggcaatgaTGATAAGGTGCGGCTTGCAatcgttgatcaggacgatacga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(858700..858774) /Source="Nicolas_S_feature" /locus_tag="new_909123_909197_c" /HighExp="LoTm, Sw, C90, HiOs, BC, MG 45, UNK1, Fru, S1, BI" /AntisenseName="yfiN" /AntisenseCor="-6.3486715356968801E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S284" downshifts complement(858743) /Source="Nicolas_upshifts" /id="D415" /incds=0 /nref=90 /ntot=257 /MaxReadThrough="1.41433" /MaxDrop="6.01369" /score="13.7314837" /energy="-11.5" /TU="U632" /idTUdmin="U632" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(858775..859323) /gene="padR" /locus_tag="BSU_08340" /old_locus_tag="BSU08340" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11073918, 17295427, 18326577, 21685295, 23189126, 27716049, 28027933" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11073918, 17295427, 18326577, 21685295, 23189126, 27716049, 28027933; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of phenolic acid decarboxylase" /protein_id="NP_388715.1" /db_xref="EnsemblGenomes-Gn:BSU08340" /db_xref="EnsemblGenomes-Tr:CAB12663" /db_xref="GOA:P94443" /db_xref="InterPro:IPR005149" /db_xref="InterPro:IPR018309" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12220" /db_xref="UniProtKB/Swiss-Prot:P94443" /translation="MRVLKYAILGLLRKGELSGYDITSYFKEELGQFWSAKHSQIYPE LKKLTDEGFITFRTTIQGTKLEKKMYTLTDSGKQELHDWLIRHQPIPETVKDEFMLKA YFISCLSRQEASDLFKDQLQKRQAKLSDLQGSYEKLMASAEPMSFSSPDFGHYLVLTK ALEREKNYVSWLESILAMIDKD*" /label="padR CDS" gene complement(858775..859323) /gene="padR" /locus_tag="BSU_08340" /old_locus_tag="BSU08340" /label="padR gene" S_feature complement(859324..859403) /Source="Nicolas_S_feature" /locus_tag="new_909747_909826_c" /HighExp="LoTm, Cold, G180, GM-0.2, Oxctl, T5.0H, GM 25, T3.30H, MG 60, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S285" promotor_-10 complement(859392..859411) /Source="Nicolas_upshift_promotors" /id="U632" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.405594405594406" /psig="0.997002997002997" /xcortree=2251 /SigmaFactorBS="acaaaccttttatcttcatttccaaagagcccgGTTGTGttc ccttcctcccTTTTCTATAATAAGGGGAATaggcagttagaatcacagttgagcaccg g" /listShort="S285, padR, S284" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(859403) /Source="Nicolas_upshifts" /id="U632" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.405594405594406" /psig="0.997002997002997" /xcortree=2251 /SigmaFactorBS="acaaaccttttatcttcatttccaaagagcccgGTTGTGttc ccttcctcccTTTTCTATAATAAGGGGAATaggcagttagaatcacagttgagcaccg g" /listShort="S285, padR, S284" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(859425..859430) /Source="Nicolas_upshift_promotors" /id="U632" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.405594405594406" /psig="0.997002997002997" /xcortree=2251 /SigmaFactorBS="acaaaccttttatcttcatttccaaagagcccgGTTGTGttc ccttcctcccTTTTCTATAATAAGGGGAATaggcagttagaatcacagttgagcaccg g" /listShort="S285, padR, S284" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 859526..859529 /Source="Nicolas_upshift_promotors" /id="U633" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.927072927072927" /psig="0.998001998001998" /xcortree=2321 /SigmaFactorBS="tataaaagagatttaaatttaattttcagaaaaaATAGtaac gatattgatttTTTATATATAATAGGAAATTggtggtatgaaaattttttgggggaat a" /listShort="estB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 859545..859564 /Source="Nicolas_upshift_promotors" /id="U633" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.927072927072927" /psig="0.998001998001998" /xcortree=2321 /SigmaFactorBS="tataaaagagatttaaatttaattttcagaaaaaATAGtaac gatattgatttTTTATATATAATAGGAAATTggtggtatgaaaattttttgggggaat a" /listShort="estB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 859552 /Source="Nicolas_upshifts" /id="U633" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.927072927072927" /psig="0.998001998001998" /xcortree=2321 /SigmaFactorBS="tataaaagagatttaaatttaattttcagaaaaaATAGtaac gatattgatttTTTATATATAATAGGAAATTggtggtatgaaaattttttgggggaat a" /listShort="estB" /GFF_Attribute="listLong" /label="upshifts" CDS 859596..860228 /gene="estB" /locus_tag="BSU_08350" /old_locus_tag="BSU08350" /EC_number="3.1.1.3" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11029590, 10913700, 21574267" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11029590, 10913700, 21574267; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="secreted esterase / acylglycerol lipase" /protein_id="NP_388716.1" /db_xref="EnsemblGenomes-Gn:BSU08350" /db_xref="EnsemblGenomes-Tr:CAB12664" /db_xref="GOA:Q79F14" /db_xref="InterPro:IPR002918" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG11951" /db_xref="UniProtKB/Swiss-Prot:Q79F14" /translation="MKKVLMAFIICLSLILSVLAAPPSGAKAESVHNPVVLVHGISGA SYNFFAIKNYLISQGWQSNKLYAIDFYDKTGNNLNNGPQLASYVDRVLKETGAKKVDI VAHSMGGANTLYYIKYLGGGNKIQNVVTLGGANGLVSSTALPGTDPNQKILYTSIYSL NDQIVINSLSRLQGARNIQLYGIGHIGLLSNSQVNGYIKEGLNGGGLNTN*" /label="estB CDS" gene 859596..860228 /gene="estB" /locus_tag="BSU_08350" /old_locus_tag="BSU08350" /label="estB gene" downshifts 860207 /Source="Nicolas_upshifts" /id="D416" /incds=0 /nref=7 /ntot=100 /MaxReadThrough="0.87881" /MaxDrop="2.6151" /score="0.223019698" /energy="-8.5" /TU="NA" /idTUdmin="U633" /TUdmin=88 /isTUend="FALSE" /label="downshifts" promotor_-35 860343..860348 /Source="Nicolas_upshift_promotors" /id="U634" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.492507492507492" /psig="0.984015984015984" /xcortree=3160 /SigmaFactorBS="tcatgcatacgtcaatttatgacatcaggcaCTTTTTcaaat agagcggaCATGTTAAGGTACAACCATCgatttctatcaatttgaaataaaaggagcg c" /listShort="yfiQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 860362..860381 /Source="Nicolas_upshift_promotors" /id="U634" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.492507492507492" /psig="0.984015984015984" /xcortree=3160 /SigmaFactorBS="tcatgcatacgtcaatttatgacatcaggcaCTTTTTcaaat agagcggaCATGTTAAGGTACAACCATCgatttctatcaatttgaaataaaaggagcg c" /listShort="yfiQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 860372 /Source="Nicolas_upshifts" /id="U634" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.492507492507492" /psig="0.984015984015984" /xcortree=3160 /SigmaFactorBS="tcatgcatacgtcaatttatgacatcaggcaCTTTTTcaaat agagcggaCATGTTAAGGTACAACCATCgatttctatcaatttgaaataaaaggagcg c" /listShort="yfiQ" /GFF_Attribute="listLong" /label="upshifts" CDS 860417..861505 /gene="icaC" /locus_tag="BSU_08360" /old_locus_tag="BSU08360" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16850406, 24776724, 25935415, 27303652; Product type t : transporter" /codon_start=1 /transl_table=11 /product="acetyl-glucosamine metabolite exporter componentinvolved in biofilm formation" /protein_id="NP_388717.1" /db_xref="EnsemblGenomes-Gn:BSU08360" /db_xref="EnsemblGenomes-Tr:CAB12665" /db_xref="GOA:O31559" /db_xref="InterPro:IPR002656" /db_xref="SubtiList:BG12893" /db_xref="UniProtKB/Swiss-Prot:O31559" /translation="MQIKEIFMIRCISCLSVVLLHIISMVLMLQAEALADISHTVDSF RTLLMFSTPAFIFISEFLLARSYPDGVPDGFLKKRGKVIFVPFLFIAAIDALLMTSAM GGEVTFLAFVQKYLANVFLGNFIGYFILVIFQFYMLHMMFHEYLKKASPKWVLSISFV VTAAYLGYFSAASPAPASEEGGAFPFFWVPFAGWLFYFCLAYYCGKEYKRFLALLNQY RWVVYGAAIASGALVVTVSYVGEIGMISSKRPDIMLYSTSMIFLCFHLFSKMKHVPKI MMFISNYSFSIYLLHAYFMIIGYVLLLNMPEIPAVPAVLLLFAVCTAGPIMTSWALNK FKYGYLFVGKIYQPKQKKVTVEVRDHAG*" /label="icaC CDS" gene 860417..861505 /gene="icaC" /locus_tag="BSU_08360" /old_locus_tag="BSU08360" /label="icaC gene" S_feature complement(860907..861295) /Source="Nicolas_S_feature" /locus_tag="new_911330_911718_c" /HighExp="S6, S8, S7, S5, LBGstat, H2O2, Mt0, Cold, G180, LPhT" /AntisenseName="yfiQ" /AntisenseCor="0.36913176163336098" /AntisenseRegPval="-9.4" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.976" /TUlongSig="NA" /TUlongPSig="NA" /label="S286" upshifts complement(861295) /Source="Nicolas_upshifts" /id="U635" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1391 /SigmaFactorBS="agccggtacggcaggaatTTCGGGCATattcaaaagcaaCAC GTAGCCTATAATCATAAaataggcatgaagcagataaatcgaaaaggaatagttgctg a" /listShort="S286" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(861297..861316) /Source="Nicolas_upshift_promotors" /id="U635" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1391 /SigmaFactorBS="agccggtacggcaggaatTTCGGGCATattcaaaagcaaCAC GTAGCCTATAATCATAAaataggcatgaagcagataaatcgaaaaggaatagttgctg a" /listShort="S286" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(861329..861337) /Source="Nicolas_upshift_promotors" /id="U635" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1391 /SigmaFactorBS="agccggtacggcaggaatTTCGGGCATattcaaaagcaaCAC GTAGCCTATAATCATAAaataggcatgaagcagataaatcgaaaaggaatagttgctg a" /listShort="S286" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(861541..862158) /gene="yfiR" /locus_tag="BSU_08370" /old_locus_tag="BSU08370" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16862575" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16862575; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (TetR/AcrR family)" /protein_id="NP_388718.1" /db_xref="EnsemblGenomes-Gn:BSU08370" /db_xref="EnsemblGenomes-Tr:CAB12666" /db_xref="GOA:O31560" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036271" /db_xref="PDB:1RKT" /db_xref="SubtiList:BG12894" /db_xref="UniProtKB/Swiss-Prot:O31560" /translation="MSPKVTKEHKDKRQAEILEAAKTVFKRKGFELTTMKDVVEESGF SRGGVYLYFSSTEEMFRRIIETGLDEGLRKLDKSAEHQSVWASISSYLDELTEGLRDV ADTLAPVQFEYLVTAWRNEERRQYLEKRYDLFVERFSRLLQKGIDQGEFQPVQPLATI AKFFLNMNDGIIQNALYFDEEKADVSGLAESAKLYLKTVLQADEK*" /label="yfiR CDS" gene complement(861541..862158) /gene="yfiR" /locus_tag="BSU_08370" /old_locus_tag="BSU08370" /label="yfiR gene" downshifts complement(861559) /Source="Nicolas_upshifts" /id="D417" /incds=0 /nref=29 /ntot=209 /MaxReadThrough="2.44114" /MaxDrop="4.07715" /score="22.1532141" /energy="-17.1" /TU="NA" /idTUdmin="U636" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(862124..863377) /gene="yfiS" /locus_tag="BSU_08380" /old_locus_tag="BSU08380" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9811639, 15849754, 16850406, 16862575; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388719.1" /db_xref="EnsemblGenomes-Gn:BSU08380" /db_xref="EnsemblGenomes-Tr:CAB12667" /db_xref="GOA:O31561" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12895" /db_xref="UniProtKB/Swiss-Prot:O31561" /translation="MEKPLFRNQKGLMTLLASQTISSLGDWLHILAVLTLAAFQLHAS PLDMSLLMMSFALPVIVLGPVSGLLADRFDRKTIMFLSEIGRALTVISCVYVSELWQL YVLLSVQSCFSSLFLPAKNGKLKELAPEAHIQQAVSVSSIIDNSSKIFGPALGGTLIA AFSIHSVFYINAGAFFLSAVILFFLPRDAFLQKANTPQEKTAALTSIKEGLQFLKRMP LLLTGLLTACVVLFVLQIGDSQAIILIRSFSGAPPELAGWCMAVSGAGMLLTAAITGR RRITSYLLYFSAGTLLLGLATGGAPFLSGMGIAGITLFIFAFFIMGAAFGLVHIPFQI LVQTTVPVDYSGRVFGAIQSATTLASILGMAGGGVLAEWIGVSLAFLVCGCLLIMIGL ITLIGKKIAESRRYLVTKSNKGAQG*" /label="yfiS CDS" gene complement(862124..863377) /gene="yfiS" /locus_tag="BSU_08380" /old_locus_tag="BSU08380" /label="yfiS gene" promotor_-10 complement(862185..862204) /Source="Nicolas_upshift_promotors" /id="U636" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.918081918081918" /psig="0.998001998001998" /xcortree=3148 /SigmaFactorBS="tcggtgtatcacttgcttttcttgtctgtggcTGCTTGCTga tcatgattgggTTGATTACACTTATAGGTAAgaaaattgcagaaagcaggcgatatct t" /listShort="yfiR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(862197) /Source="Nicolas_upshifts" /id="U636" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.918081918081918" /psig="0.998001998001998" /xcortree=3148 /SigmaFactorBS="tcggtgtatcacttgcttttcttgtctgtggcTGCTTGCTga tcatgattgggTTGATTACACTTATAGGTAAgaaaattgcagaaagcaggcgatatct t" /listShort="yfiR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(862218..862225) /Source="Nicolas_upshift_promotors" /id="U636" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.918081918081918" /psig="0.998001998001998" /xcortree=3148 /SigmaFactorBS="tcggtgtatcacttgcttttcttgtctgtggcTGCTTGCTga tcatgattgggTTGATTACACTTATAGGTAAgaaaattgcagaaagcaggcgatatct t" /listShort="yfiR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(863411..863430) /Source="Nicolas_upshift_promotors" /id="U637" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.492507492507492" /psig="0.99100899100899" /xcortree=2727 /SigmaFactorBS="cttctattcaatcttctcctttattttacaagaaaaaGATTG TATattgtgtctttttcCCATACAATTAAAAACGACActagtgtcattttaataatca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(863429) /Source="Nicolas_upshifts" /id="U637" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.492507492507492" /psig="0.99100899100899" /xcortree=2727 /SigmaFactorBS="cttctattcaatcttctcctttattttacaagaaaaaGATTG TATattgtgtctttttcCCATACAATTAAAAACGACActagtgtcattttaataatca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(863445..863452) /Source="Nicolas_upshift_promotors" /id="U637" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.492507492507492" /psig="0.99100899100899" /xcortree=2727 /SigmaFactorBS="cttctattcaatcttctcctttattttacaagaaaaaGATTG TATattgtgtctttttcCCATACAATTAAAAACGACActagtgtcattttaataatca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 863456..863475 /Source="Nicolas_upshift_promotors" /id="U638" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.77022977022977" /psig="0.98901098901099" /xcortree=3204 /SigmaFactorBS="atgacactagtgtcgtttttaattgtatgggaaaaagacaca atatacaatctttTTCTTGTAAAATAAAGGAGAagattgaatagaagggagaacattc a" /listShort="yfiT" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 863461 /Source="Nicolas_upshifts" /id="U638" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.77022977022977" /psig="0.98901098901099" /xcortree=3204 /SigmaFactorBS="atgacactagtgtcgtttttaattgtatgggaaaaagacaca atatacaatctttTTCTTGTAAAATAAAGGAGAagattgaatagaagggagaacattc a" /listShort="yfiT" /GFF_Attribute="listLong" /label="upshifts" CDS 863501..864037 /gene="bstA" /locus_tag="BSU_08390" /old_locus_tag="BSU08390" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15581359, 22059487, 24821014, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15581359, 22059487, 24821014, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bacillithiol S-transferase" /protein_id="NP_388720.1" /db_xref="EnsemblGenomes-Gn:BSU08390" /db_xref="EnsemblGenomes-Tr:CAB12668" /db_xref="GOA:O31562" /db_xref="InterPro:IPR023774" /db_xref="InterPro:IPR024775" /db_xref="InterPro:IPR034660" /db_xref="PDB:1RXQ" /db_xref="SubtiList:BG12896" /db_xref="UniProtKB/Swiss-Prot:O31562" /translation="MTSVNLSYPIGEYKPRESISKEQKDKWIQVLEEVPAKLKQAVEV MTDSQLDTPYRDGGWTVRQVVHHLADSHMNSYIRFKLSLTEETPAIRPYDEKAWSELK DSKTADPSGSLALLQELHGRWTALLRTLTDQQFKRGFYHPDTKEIITLENALGLYVWH SHHHIAHITELSRRMGWS*" /label="bstA CDS" gene 863501..864037 /gene="bstA" /locus_tag="BSU_08390" /old_locus_tag="BSU08390" /label="bstA gene" CDS complement(864034..865590) /gene="yfiU" /locus_tag="BSU_08400" /old_locus_tag="BSU08400" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388721.1" /db_xref="EnsemblGenomes-Gn:BSU08400" /db_xref="EnsemblGenomes-Tr:CAB12669" /db_xref="GOA:O31563" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12897" /db_xref="UniProtKB/Swiss-Prot:O31563" /translation="MSEALTEQKSQKWAISLFTIGVFMAALDNGIISAALTTINESFS VSPSWGSWGITLYTLGLSVSVPIVGKLSDRYGRKKLFLIEVCLFGLGSLLVALSQSFP LFLISRLIQALGGGGIFIIGSSHILATLPKEKQGKALGLLGAMNGMAAVLGPNIGSFL LDWTGSWHWLFLINLPIAVLLVVFGACFIAETKAPEAKRLDAAGIFLLSLSILAVMYG MTNLDGANLLHSLGNPEVYGCIIFGILCFAALISYEKRVEMRGGDPILAYSLLRNHMF QRTLIIGLLSGGLLAAVIFIPSYVEQYLGVPAAKAGYWMTPLALASGIGAWLGGALTD KKGPVKTVILSGIISCAGFALFPLWVTEKWEFVIASVAAGIGFGFLLGAPLNVLVSEA AKTNKGTALGTLSLVRQIGLTLAPTLYAGFITAGFDQIGDEINSRLSDSGYSEKAMQM IPEIDSSEVSSLQEQIERIPVPEVKTAISDAIHASVASGYDHLYAAAAVVSLLVIAAI SIPAFRRQKR*" /label="yfiU CDS" gene complement(864034..865590) /gene="yfiU" /locus_tag="BSU_08400" /old_locus_tag="BSU08400" /label="yfiU gene" promotor_-10 complement(865612..865630) /Source="Nicolas_upshift_promotors" /id="U639" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.623376623376623" /psig="0.623376623376623" /xcortree=795 /SigmaFactorBS="tgtcatccgcaaactgcgggagcaggctttttttatttgaCA TTtagttcatttaaaatGAATAATATATTTCAAGTGaactaaaaggagttgacgaaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(865629) /Source="Nicolas_upshifts" /id="U639" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.623376623376623" /psig="0.623376623376623" /xcortree=795 /SigmaFactorBS="tgtcatccgcaaactgcgggagcaggctttttttatttgaCA TTtagttcatttaaaatGAATAATATATTTCAAGTGaactaaaaggagttgacgaaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(865646..865649) /Source="Nicolas_upshift_promotors" /id="U639" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.623376623376623" /psig="0.623376623376623" /xcortree=795 /SigmaFactorBS="tgtcatccgcaaactgcgggagcaggctttttttatttgaCA TTtagttcatttaaaatGAATAATATATTTCAAGTGaactaaaaggagttgacgaaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(865701..866183) /gene="yfiV" /locus_tag="BSU_08410" /old_locus_tag="BSU08410" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 18990441; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MarR family)" /protein_id="NP_388722.1" /db_xref="EnsemblGenomes-Gn:BSU08410" /db_xref="EnsemblGenomes-Tr:CAB12670" /db_xref="GOA:O31564" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12898" /db_xref="UniProtKB/Swiss-Prot:O31564" /translation="MEYNLHDTTVLNENILSSEEREIWVLYMKVLTSAGLGDVSEWMK LDMSMPQMKVLMLLNNHGTLKVSDIAEKMGASLSNTTGLLDRLEKSGFVKRSHSEEDR RSVVVQLTENAKKIFRGLYEKGHLKLKRSLELLSPEEKQAVYEGLSILSRALENAKKE *" /label="yfiV CDS" gene complement(865701..866183) /gene="yfiV" /locus_tag="BSU_08410" /old_locus_tag="BSU08410" /label="yfiV gene" downshifts complement(865717) /Source="Nicolas_upshifts" /id="D418" /incds=0 /nref=58 /ntot=177 /MaxReadThrough="1.47849" /MaxDrop="4.15907" /score="27.2704527" /energy="-14.2" /TU="NA" /idTUdmin="U640" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(866208..866227) /Source="Nicolas_upshift_promotors" /id="U640" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.542457542457542" /psig="0.998001998001998" /xcortree=2019 /SigmaFactorBS="atttttcggacaaagtcccgcatgcggtttctgctcACTTTC TttcaggagtgaaaaTCGAGTAATATGGTAAGAGGagtgaatgatgaggaagtgatga a" /listShort="yfiV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(866224) /Source="Nicolas_upshifts" /id="U640" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.542457542457542" /psig="0.998001998001998" /xcortree=2019 /SigmaFactorBS="atttttcggacaaagtcccgcatgcggtttctgctcACTTTC TttcaggagtgaaaaTCGAGTAATATGGTAAGAGGagtgaatgatgaggaagtgatga a" /listShort="yfiV" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(866242..866248) /Source="Nicolas_upshift_promotors" /id="U640" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.542457542457542" /psig="0.998001998001998" /xcortree=2019 /SigmaFactorBS="atttttcggacaaagtcccgcatgcggtttctgctcACTTTC TttcaggagtgaaaaTCGAGTAATATGGTAAGAGGagtgaatgatgaggaagtgatga a" /listShort="yfiV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 866269..866276 /Source="Nicolas_upshift_promotors" /id="U641" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.544455544455544" /psig=1 /xcortree=2519 /SigmaFactorBS="tgaaagaaagtgagcagaaaccgcatgcgggACTTTGTCcga aaaataacggTAGTGTATAATGAGTTGGAGattattgggggagaggatcgaactagaa t" /listShort="mprF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 866290..866309 /Source="Nicolas_upshift_promotors" /id="U641" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.544455544455544" /psig=1 /xcortree=2519 /SigmaFactorBS="tgaaagaaagtgagcagaaaccgcatgcgggACTTTGTCcga aaaataacggTAGTGTATAATGAGTTGGAGattattgggggagaggatcgaactagaa t" /listShort="mprF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 866298 /Source="Nicolas_upshifts" /id="U641" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.544455544455544" /psig=1 /xcortree=2519 /SigmaFactorBS="tgaaagaaagtgagcagaaaccgcatgcgggACTTTGTCcga aaaataacggTAGTGTATAATGAGTTGGAGattattgggggagaggatcgaactagaa t" /listShort="mprF" /GFF_Attribute="listLong" /label="upshifts" CDS 866355..868925 /gene="mprF" /locus_tag="BSU_08425" /old_locus_tag="BSU08425" /EC_number="2.3.2.3" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:2139213, 2490162, 12427923, 14702396, 15849754, 16299297, 16850406, 17042784, 19074395, 21306448, 26261323" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2139213, 2490162, 12427923, 14702396, 15849754, 16299297, 16850406, 17042784, 19074395, 21306448, 26261323; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="phosphatidylglycerol lysyltransferase involved in tRNA-dependent lysinylation of phospholipids" /protein_id="YP_003097695.1" /db_xref="EnsemblGenomes-Gn:BSU08425" /db_xref="EnsemblGenomes-Tr:CAX52582" /db_xref="GOA:C0H3X7" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR022791" /db_xref="InterPro:IPR024320" /db_xref="UniProtKB/Swiss-Prot:C0H3X7" /translation="MLIKKNALSILKIVFPIAVLLFVIYQSKKELTNLSFKRTLMVIN GLERTDLFMLVLIGLLAVAAMSLYDYVLKYSLRLSITNGKVFRVSWIANSFNNVLGFG GLAGVGLRMMFYKEHTKDHKALVKGIAWLTSSMLLGLSVFSIFVAARVLPVDEVIHEK PWLWAVVIGFALILPLSLAVSKIKDRKAGDEENADKVKNPIFAYIGASVVEWLMAGTV IYFALFAMGIHADIRYVFGVFVIAAIGGMISLVPGGFGSFDLLFLLGMEQLGYHQEAI VTSIVLYRLAYSFIPFILGLFFAAGDLTENTMKRLETNPRIAPAIETTNVLLVVQRAV LVRILQGSLSLIVFVAGLIVLASVSLPIDRLTVIPHIPRPALLLFNGLSLSSALILLI LPIELYKRTKRSYTMAITALVGGFVFSFLKGLNISAIFVLPMIIVLLVLLKKQFVREQ ASYTLGQLIFAVALFTVALFNYNLIAGFIWDRMKKVLRHEYFVHSTSHITHATIMAII IVPLFFLIFTVVYHKRTKPIGEKADPERLAAFLNEKGGNALSHLGFLGDKRFYFSSDG NALLLFGKIARRLVVLGDPSGQRESFPLVLEEFLNEAHQKGFSVLFYQIEREDMALYH DFGYNFFKLGEEAYVDLNTFTLTGKKKAGLRAINNRFEREEYTFHVDHPPFSDAFLEE LKQISDEWLGSKKEKGFSLGFFDPSYLQKAPIAYMKNAEGEIVAFANVMPMYQEGEIS VDLMRYRGDAPNGIMDALFIRMFLWAKEEGCTSFNMGMAPLANVGTAFTSFWSERFAA VIFNNVRYMYSFSGLRAFKEKYKPEWRGKYLAYRKNRSLSVTMFLVTRLIGKSKKDSV *" /label="mprF CDS" gene 866355..868925 /gene="mprF" /locus_tag="BSU_08425" /old_locus_tag="BSU08425" /label="mprF gene" downshifts 868896 /Source="Nicolas_upshifts" /id="D419" /incds=0 /nref=121 /ntot=252 /MaxReadThrough="1.79352" /MaxDrop="5.78159" /score="49.2396824" /energy="-16.1" /TU="NA" /idTUdmin="U641" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(868943..869920) /gene="sxzY" /locus_tag="BSU_08440" /old_locus_tag="BSU08440" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 12354229, 19254027, 24606332; Product type t: transporter" /codon_start=1 /transl_table=11 /product="xenosiderophore schizokinen (dihydroxamate) transporter binding lipoprotein" /protein_id="NP_388725.1" /db_xref="EnsemblGenomes-Gn:BSU08440" /db_xref="EnsemblGenomes-Tr:CAB12673" /db_xref="GOA:O31567" /db_xref="InterPro:IPR002491" /db_xref="SubtiList:BG12901" /db_xref="UniProtKB/Swiss-Prot:O31567" /translation="MKKHISMLFVFLMAVMVLSACNSSESSSNSEVSSSKTRTVKHAM GTSDNIPANPKRIVVLTNEGTEALLALGIKPVGAVKSWKGDPWYDYLKDDMKGVKNVG LETEPNVEAIAELKPDLIIGNKVRQEKIYDQLNAIAPTVFAESLAGNWKDNLTLYANA VNKADKGKEVIADFDKRVSDLKNKLGDQTNKTVSVVRFLSGESRIYYTDSFPGIILDQ LGFKRPEKQVELFKKQKDQFTFSTDSKESIPDMDADVLFYFTYKADNAKENEKWANQW TSSSLWKNLKAVKSGNAHEVDDVVWTTAGGIKAANYLLDDIETYFLKTK*" /label="sxzY CDS" gene complement(868943..869920) /gene="sxzY" /locus_tag="BSU_08440" /old_locus_tag="BSU08440" /label="sxzY gene" downshifts complement(868954) /Source="Nicolas_upshifts" /id="D420" /incds=0 /nref=165 /ntot=248 /MaxReadThrough="1.28876" /MaxDrop="7.70135" /score="35.2605181" /energy="-16.1" /TU="NA" /idTUdmin="U643" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" promotor_-35 869935..869942 /Source="Nicolas_upshift_promotors" /id="U642" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.458541458541459" /psig="0.998001998001998" /xcortree=2100 /SigmaFactorBS="gcatgctgatatgctttttcatctttttcctcccaaTATTGA AAttcattatcatttaGATCATAATAAGCAGTGTTAagagtgtcaatccctaattgag g" /listShort="S287, yfiZ, yfhA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(869947..869966) /Source="Nicolas_upshift_promotors" /id="U643" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96003996003996" /psig=1 /xcortree=2109 /SigmaFactorBS="tgtaatgtttgtttttgagaataatcctcaattaggGATTGA CActcttaacactgctTATTATGATCTAAATGATAAtgaatttcaatattgggaggaa a" /listShort="yfiY" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 869957..869976 /Source="Nicolas_upshift_promotors" /id="U642" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.458541458541459" /psig="0.998001998001998" /xcortree=2100 /SigmaFactorBS="gcatgctgatatgctttttcatctttttcctcccaaTATTGA AAttcattatcatttaGATCATAATAAGCAGTGTTAagagtgtcaatccctaattgag g" /listShort="S287, yfiZ, yfhA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 869959..870050 /Source="Nicolas_S_feature" /locus_tag="new_920382_920473" /HighExp="dia0, Lbexp, LBGexp, H2O2, G150, GM 10, Oxctl, dia15, Paraq, GM 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S287" upshifts 869959 /Source="Nicolas_upshifts" /id="U642" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.458541458541459" /psig="0.998001998001998" /xcortree=2100 /SigmaFactorBS="gcatgctgatatgctttttcatctttttcctcccaaTATTGA AAttcattatcatttaGATCATAATAAGCAGTGTTAagagtgtcaatccctaattgag g" /listShort="S287, yfiZ, yfhA" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(869964) /Source="Nicolas_upshifts" /id="U643" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96003996003996" /psig=1 /xcortree=2109 /SigmaFactorBS="tgtaatgtttgtttttgagaataatcctcaattaggGATTGA CActcttaacactgctTATTATGATCTAAATGATAAtgaatttcaatattgggaggaa a" /listShort="yfiY" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(869981..869988) /Source="Nicolas_upshift_promotors" /id="U643" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96003996003996" /psig=1 /xcortree=2109 /SigmaFactorBS="tgtaatgtttgtttttgagaataatcctcaattaggGATTGA CActcttaacactgctTATTATGATCTAAATGATAAtgaatttcaatattgggaggaa a" /listShort="yfiY" /GFF_Attribute="listLong" /label="promotor_-35" CDS 870051..871052 /gene="sxzZ" /locus_tag="BSU_08450" /old_locus_tag="BSU08450" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 15849754, 16672620, 16850406, 19254027" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15849754, 16672620, 16850406, 19254027; Product type t : transporter" /codon_start=1 /transl_table=11 /product="xenosiderophore schizokinen (dihydroxamate) transporter (permease)" /protein_id="NP_388726.1" /db_xref="EnsemblGenomes-Gn:BSU08450" /db_xref="EnsemblGenomes-Tr:CAB12674" /db_xref="GOA:O31568" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG12902" /db_xref="UniProtKB/Swiss-Prot:O31568" /translation="MICKKASSKWIVLVCLIFILLTAVCASVVYGYTGTSWRQVYQAF TSFNGTNEHVIIKDVRLPRALVATVVGASLAAAGALMQALTKNPLASPGIFGINAGAG FFIVAGSFFLHIQSPQALVWSSFLGAAFTAAIVYAAGSLGREGLTPIKLTLAGAAMAA MFSSLTQGLLSVNELELAQVLFWLTGSVQGRSLDLLMTMFPYAAAALVICFFLGQKIN LLVMGEDVAKGLGQKTGLLKFVMALCVVMLAGSAVAIAGPISFIGIIIPHFARFVVGN DYRWVLPFSAVLGAILLVCADIGARYIIMPQEVPVGVMTAIIGMPVFVYIARRGAKL* " /label="sxzZ CDS" gene 870051..871052 /gene="sxzZ" /locus_tag="BSU_08450" /old_locus_tag="BSU08450" /label="sxzZ gene" CDS 871049..872080 /gene="sxzA" /locus_tag="BSU_08460" /old_locus_tag="BSU08460" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 15849754, 16672620, 16850406, 19254027" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15849754, 16672620, 16850406, 19254027; Product type t : transporter" /codon_start=1 /transl_table=11 /product="xenosiderophore schizokinen (dihydroxamate) transporter (permease)" /protein_id="NP_388727.1" /db_xref="EnsemblGenomes-Gn:BSU08460" /db_xref="EnsemblGenomes-Tr:CAB12675" /db_xref="GOA:O31569" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG12876" /db_xref="UniProtKB/Swiss-Prot:O31569" /translation="MKLRFGVTAAEKKAWIVFLVLLGLTAAVLIISAGLGQRFIPPWD VAKTFFGAGSKLDELMIMSFRMPRILTALCAGVCLAAAGAILQGLVRNPLASPDIIGI TGGAAVAVVLLMMFFSDRSSSLTISLSWLPAAAFIGASAVGLIVYLLAYKNGASTFRL VLIGIGFSMSAQAMTTLLMIKGPIYRASQANVYITGSVYGSNWQHVKIAIILSVILLF ICFVALKNMNIQVLGEDIAAGAGSAVQRNRFFLLLLSTALTGCAVSVAGTIGFVGLMA PHIARRLVGSSYGALLPASALIGALLVLTADIVGRTLFAPVEVPAGVFTAAIGAPYFI YLLYKTRNS*" /label="sxzA CDS" gene 871049..872080 /gene="sxzA" /locus_tag="BSU_08460" /old_locus_tag="BSU08460" /label="sxzA gene" downshifts 872061 /Source="Nicolas_upshifts" /id="D421" /incds=0 /nref=24 /ntot=154 /MaxReadThrough="3.26686" /MaxDrop="4.27732" /score="19.6751667" /energy="-12.8" /TU="NA" /idTUdmin="U642" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" promotor_-35 872131..872133 /Source="Nicolas_upshift_promotors" /id="U644" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.945054945054945" /psig="0.999000999001" /xcortree=2943 /SigmaFactorBS="attttcttaaaaaagaaaatgggtttttttgataatgacTGA agattcgtaattattTTTGCTATACTGACAGAGACattgataaagaaagggcggcaga t" /listShort="yfhB, yfhC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 872149..872168 /Source="Nicolas_upshift_promotors" /id="U644" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.945054945054945" /psig="0.999000999001" /xcortree=2943 /SigmaFactorBS="attttcttaaaaaagaaaatgggtttttttgataatgacTGA agattcgtaattattTTTGCTATACTGACAGAGACattgataaagaaagggcggcaga t" /listShort="yfhB, yfhC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 872152 /Source="Nicolas_upshifts" /id="U644" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.945054945054945" /psig="0.999000999001" /xcortree=2943 /SigmaFactorBS="attttcttaaaaaagaaaatgggtttttttgataatgacTGA agattcgtaattattTTTGCTATACTGACAGAGACattgataaagaaagggcggcaga t" /listShort="yfhB, yfhC" /GFF_Attribute="listLong" /label="upshifts" CDS 872195..873076 /gene="yfhB" /locus_tag="BSU_08470" /old_locus_tag="BSU08470" /EC_number="5.1.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative isomerase" /protein_id="NP_388728.1" /db_xref="EnsemblGenomes-Gn:BSU08470" /db_xref="EnsemblGenomes-Tr:CAB12676" /db_xref="GOA:O31570" /db_xref="InterPro:IPR003719" /db_xref="SubtiList:BG12877" /db_xref="UniProtKB/Swiss-Prot:O31570" /translation="MKEAEVLKYEAFTSSPGKGNPAGVVLQGDDYTEDEMQIIAERAG YSETSFIRKSESADLELRYFTPGHEMNLCGHATVASLYALCEKGMLESGKTYSIQTKA GILPVKISEKDGRIHITLEQASPQFKPFTGDRKKLADALGITDEDFHEDLPIVFGSTG IWTAIVPLKSLEASKKMVPDNKQFPEVLVDLPKASVHPFTFETVHPDSDLHGRHFSSP YSGTIEDPVTGTASGVMGAYMKHYGNAEQHKFIIEQGQEIGKDGKVEIEMNEAGGHVK VNMTGTAVYSETRILKI*" /label="yfhB CDS" gene 872195..873076 /gene="yfhB" /locus_tag="BSU_08470" /old_locus_tag="BSU08470" /label="yfhB gene" promotor_-35 873087..873094 /Source="Nicolas_upshift_promotors" /id="U645" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.719280719280719" /psig="0.998001998001998" /xcortree=2110 /SigmaFactorBS="cgtattcttaaaatctaatacggatgatGGTTTACAaaaaga tgcactttcCGTTATCATTATGAAATGATaatcattttcaattgcataggaaggtgag a" /listShort="yfhC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 873110..873129 /Source="Nicolas_upshift_promotors" /id="U645" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.719280719280719" /psig="0.998001998001998" /xcortree=2110 /SigmaFactorBS="cgtattcttaaaatctaatacggatgatGGTTTACAaaaaga tgcactttcCGTTATCATTATGAAATGATaatcattttcaattgcataggaaggtgag a" /listShort="yfhC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 873119 /Source="Nicolas_upshifts" /id="U645" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.719280719280719" /psig="0.998001998001998" /xcortree=2110 /SigmaFactorBS="cgtattcttaaaatctaatacggatgatGGTTTACAaaaaga tgcactttcCGTTATCATTATGAAATGATaatcattttcaattgcataggaaggtgag a" /listShort="yfhC" /GFF_Attribute="listLong" /label="upshifts" CDS 873164..873748 /gene="yfhC" /locus_tag="BSU_08480" /old_locus_tag="BSU08480" /EC_number="1.6.99.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12354229, 22287527; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase (nitroreductase family)" /protein_id="NP_388729.1" /db_xref="EnsemblGenomes-Gn:BSU08480" /db_xref="EnsemblGenomes-Tr:CAB12677" /db_xref="GOA:O31571" /db_xref="InterPro:IPR000415" /db_xref="InterPro:IPR026021" /db_xref="InterPro:IPR029479" /db_xref="SubtiList:BG12878" /db_xref="UniProtKB/Swiss-Prot:O31571" /translation="MPQTEQIHQHSVLRDIIRSRRSIRKFKQEPVPSAVILDMLETAK YAPNHRVTEPWRFIYVSSETGKANLINTFAAFSKKSKPDMTEEKLQNFKNTLGRVPGF LLVVFQEDENERARDDDFAATSSLIQNLQLLAWEKGIGMVWKSGKILYDKEVHQAFGL QDNERFAAIIQTGYPDEAPEVKKRTPIRDRFTEM*" /label="yfhC CDS" gene 873164..873748 /gene="yfhC" /locus_tag="BSU_08480" /old_locus_tag="BSU08480" /label="yfhC gene" downshifts 873735 /Source="Nicolas_upshifts" /id="D422" /incds=0 /nref=208 /ntot=262 /MaxReadThrough="3.27483" /MaxDrop="6.40857" /score="21.7703837" /energy="-18.2" /TU="U645" /idTUdmin="U644" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(873787..873978) /gene="yfhD" /locus_tag="BSU_08490" /old_locus_tag="BSU08490" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388730.1" /db_xref="EnsemblGenomes-Gn:BSU08490" /db_xref="EnsemblGenomes-Tr:CAB12678" /db_xref="InterPro:IPR025435" /db_xref="SubtiList:BG12879" /db_xref="UniProtKB/Swiss-Prot:O31572" /translation="MGRNHIHKNRDKNKQKLPQVPDALKRETDGVYEEYSTELADADD REAQERAKAADNRAKKKSR*" /label="yfhD CDS" gene complement(873787..873978) /gene="yfhD" /locus_tag="BSU_08490" /old_locus_tag="BSU08490" /label="yfhD gene" downshifts complement(873805) /Source="Nicolas_upshifts" /id="D423" /incds=0 /nref=65 /ntot=197 /MaxReadThrough="0.436919999999999" /MaxDrop="8.51174" /score="30.1998663" /energy="-18.2" /TU="NA" /idTUdmin="U649" /TUdmin=7 /isTUend="TRUE" /label="downshifts" upshifts complement(874010) /Source="Nicolas_upshifts" /id="U646" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=840 /SigmaFactorBS="cggaaaaagctgctaagcggaagtaGGAATACatagcccctt aaaaCCAAATACTATAtttgtttgatatcactttttagggggaatttgatatgggcag a" /listShort="yfhD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(874013..874024) /Source="Nicolas_upshift_promotors" /id="U646" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=840 /SigmaFactorBS="cggaaaaagctgctaagcggaagtaGGAATACatagcccctt aaaaCCAAATACTATAtttgtttgatatcactttttagggggaatttgatatgggcag a" /listShort="yfhD" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(874039..874045) /Source="Nicolas_upshift_promotors" /id="U646" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=840 /SigmaFactorBS="cggaaaaagctgctaagcggaagtaGGAATACatagcccctt aaaaCCAAATACTATAtttgtttgatatcactttttagggggaatttgatatgggcag a" /listShort="yfhD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(874045..874155) /gene="yfhE" /locus_tag="BSU_08500" /old_locus_tag="BSU08500" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_388731.1" /db_xref="EnsemblGenomes-Gn:BSU08500" /db_xref="EnsemblGenomes-Tr:CAB12679" /db_xref="InterPro:IPR025437" /db_xref="SubtiList:BG12880" /db_xref="UniProtKB/Swiss-Prot:O31573" /translation="MEKKREKHQQGANLKKMQEVLYSGEFKKAEKAAKRK*" /label="yfhE CDS" gene complement(874045..874155) /gene="yfhE" /locus_tag="BSU_08500" /old_locus_tag="BSU08500" /label="yfhE gene" promotor_-10 complement(874184..874195) /Source="Nicolas_upshift_promotors" /id="U647" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1140 /SigmaFactorBS="actctcacagctgatagcggaccgaaagacTGTATAAaaaca gcaggaagcGTCAACCTTAAGaataacatggttgaaggaggtcctttttatggaaaaa a" /listShort="yfhE, yfhD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(874186) /Source="Nicolas_upshifts" /id="U647" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1140 /SigmaFactorBS="actctcacagctgatagcggaccgaaagacTGTATAAaaaca gcaggaagcGTCAACCTTAAGaataacatggttgaaggaggtcctttttatggaaaaa a" /listShort="yfhE, yfhD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(874210..874216) /Source="Nicolas_upshift_promotors" /id="U647" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1140 /SigmaFactorBS="actctcacagctgatagcggaccgaaagacTGTATAAaaaca gcaggaagcGTCAACCTTAAGaataacatggttgaaggaggtcctttttatggaaaaa a" /listShort="yfhE, yfhD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(874210..875121) /gene="yfhF" /locus_tag="BSU_08510" /old_locus_tag="BSU08510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative nucleotide-or NAD-binding protein" /protein_id="NP_388732.1" /db_xref="EnsemblGenomes-Gn:BSU08510" /db_xref="EnsemblGenomes-Tr:CAB12680" /db_xref="GOA:O31574" /db_xref="InterPro:IPR001509" /db_xref="InterPro:IPR010099" /db_xref="InterPro:IPR013549" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12881" /db_xref="UniProtKB/Swiss-Prot:O31574" /translation="MNIAMTGGTGFLGQHLTGVLTRQGHHVYILSRNARETEQKNMTY VQWLSEGAAPEQELPHIDVWINLAGKSIFGRWTEKTKQHILSSRINATREVQRLIQKQ KEKPKTLIQASAVGIYGTSLEKTFTEDSATSDEDFLSHTAHLWEKEGQHIEAMGIRTV YARFGVMLGEKGALPLMILPYKFLAGGTIGTGRQWLSWIHVEDAAQMIRYAVENAGIS GPMNVTAPNPVDMKQFGKTIARVKHRPHWLPVPEFFLSKALGEMSLLIVKGQRALPKK AITSGFRFTYSDLEFALSQLIADRKTV*" /label="yfhF CDS" gene complement(874210..875121) /gene="yfhF" /locus_tag="BSU_08510" /old_locus_tag="BSU08510" /label="yfhF gene" promotor_-35 875007..875010 /Source="Nicolas_upshift_promotors" /id="U648" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.531468531468531" /psig="0.999000999001" /xcortree=2741 /SigmaFactorBS="acagccattggacatatgtcatatttttttGTTCagtttccc ttgcgtttCTTGATAAAATATAAACATGgtgtccctggcgggtaagaacgcctgtcag a" /listShort="S288, recX, yfhH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 875027..875046 /Source="Nicolas_upshift_promotors" /id="U648" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.531468531468531" /psig="0.999000999001" /xcortree=2741 /SigmaFactorBS="acagccattggacatatgtcatatttttttGTTCagtttccc ttgcgtttCTTGATAAAATATAAACATGgtgtccctggcgggtaagaacgcctgtcag a" /listShort="S288, recX, yfhH" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 875037..875209 /Source="Nicolas_S_feature" /locus_tag="new_925460_925632" /HighExp="LBGstat, Lbtran, T1.30H, T2.0H, T2.30H, M9-stat, T1.0H, T3.0H, Sw, G180" /AntisenseName="yfhF" /AntisenseCor="-5.3501479327985699E-2" /AntisenseRegPval="-0.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S288" upshifts 875037 /Source="Nicolas_upshifts" /id="U648" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.531468531468531" /psig="0.999000999001" /xcortree=2741 /SigmaFactorBS="acagccattggacatatgtcatatttttttGTTCagtttccc ttgcgtttCTTGATAAAATATAAACATGgtgtccctggcgggtaagaacgcctgtcag a" /listShort="S288, recX, yfhH" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(875143..875161) /Source="Nicolas_upshift_promotors" /id="U649" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=135 /SigmaFactorBS="aacggcatcttaatctcccttctcaggcctgaaacgCGTTTT CttttattacaatgAGGTAAAGTATATTTATTAgaacgatgaggagagatgttcatga a" /listShort="yfhF, yfhE, yfhD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(875157) /Source="Nicolas_upshifts" /id="U649" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=135 /SigmaFactorBS="aacggcatcttaatctcccttctcaggcctgaaacgCGTTTT CttttattacaatgAGGTAAAGTATATTTATTAgaacgatgaggagagatgttcatga a" /listShort="yfhF, yfhE, yfhD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(875175..875181) /Source="Nicolas_upshift_promotors" /id="U649" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=135 /SigmaFactorBS="aacggcatcttaatctcccttctcaggcctgaaacgCGTTTT CttttattacaatgAGGTAAAGTATATTTATTAgaacgatgaggagagatgttcatga a" /listShort="yfhF, yfhE, yfhD" /GFF_Attribute="listLong" /label="promotor_-35" CDS 875210..876004 /gene="recX" /locus_tag="BSU_08520" /old_locus_tag="BSU08520" /function="16.3: Control" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:8946165, 10869079, 12547390, 23284295, 24285298" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8946165, 10869079, 12547390, 23284295, 24285298; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulatory protein RecX" /protein_id="NP_388733.1" /db_xref="EnsemblGenomes-Gn:BSU08520" /db_xref="EnsemblGenomes-Tr:CAB12681" /db_xref="GOA:O31575" /db_xref="InterPro:IPR003783" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12882" /db_xref="UniProtKB/Swiss-Prot:O31575" /translation="MPFITKISTQKKNTERFNIFLDDKYAFSVDADVLVKFELKKGKE LDDLDIIEIQYGDEVKKGFNRALDFLSYRMRSTKEVEDHLKKKETSPPVIAEVIHRLN DYKYLNDQEFAAAYVSTHKKTNGKGPDVLFRELRAKGIDDDTIKEALSSFSFEDQTRE AVKHVEKLLKKDKKLSTKELKQRAQLQLQRKGFSFDVISAAMDQIEYENDEDTEKEAL RLHAEKAFRKYRYDGSYESAMKVKQFLFRKGFSLDLIEQLLQEEEY*" /label="recX CDS" gene 875210..876004 /gene="recX" /locus_tag="BSU_08520" /old_locus_tag="BSU08520" /label="recX gene" CDS 876006..876320 /gene="yfhH" /locus_tag="BSU_08530" /old_locus_tag="BSU08530" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388734.1" /db_xref="EnsemblGenomes-Gn:BSU08530" /db_xref="EnsemblGenomes-Tr:CAB12682" /db_xref="InterPro:IPR014938" /db_xref="InterPro:IPR036289" /db_xref="PDB:1SF9" /db_xref="SubtiList:BG12883" /db_xref="UniProtKB/Swiss-Prot:O31576" /translation="MEKRYSQMTPHELNTEIALLSEKARKAEQHGIINELAVLERKIT MAKAYLLNPEDYSPGETYRVENTEDEFTISYLNGVFAWGYRTSSPQQEEALPISVLQE KE*" /label="yfhH CDS" gene 876006..876320 /gene="yfhH" /locus_tag="BSU_08530" /old_locus_tag="BSU08530" /label="yfhH gene" S_feature complement(876228..876496) /Source="Nicolas_S_feature" /locus_tag="new_926651_926919_c" /HighExp="S8, S6, S5, S7, C30, S4, nit, ferm, BT, G135" /AntisenseName="yfhH" /AntisenseCor="-0.53569713251514905" /AntisenseRegPval="-20.7" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S289" downshifts 876310 /Source="Nicolas_upshifts" /id="D424" /incds=0 /nref=71 /ntot=206 /MaxReadThrough="2.93348" /MaxDrop="5.2859" /score="24.7235138" /energy="-11.6" /TU="NA" /idTUdmin="U648" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 876394..876399 /Source="Nicolas_upshift_promotors" /id="U650" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.460539460539461" /psig=1 /xcortree=2471 /SigmaFactorBS="cagcacatttacacgaattcttaaagaaaaaatcATTGAAtt cacttgaaaaatcTTTTAAGATGAAACTCGTTGttttttaaaatcaaaggaggcgatg a" /listShort="yfhI, S290, S291, yfhJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 876415..876434 /Source="Nicolas_upshift_promotors" /id="U650" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.460539460539461" /psig=1 /xcortree=2471 /SigmaFactorBS="cagcacatttacacgaattcttaaagaaaaaatcATTGAAtt cacttgaaaaatcTTTTAAGATGAAACTCGTTGttttttaaaatcaaaggaggcgatg a" /listShort="yfhI, S290, S291, yfhJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 876420 /Source="Nicolas_upshifts" /id="U650" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.460539460539461" /psig=1 /xcortree=2471 /SigmaFactorBS="cagcacatttacacgaattcttaaagaaaaaatcATTGAAtt cacttgaaaaatcTTTTAAGATGAAACTCGTTGttttttaaaatcaaaggaggcgatg a" /listShort="yfhI, S290, S291, yfhJ" /GFF_Attribute="listLong" /label="upshifts" CDS 876463..877656 /gene="yfhI" /locus_tag="BSU_08540" /old_locus_tag="BSU08540" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22226636; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388735.1" /db_xref="EnsemblGenomes-Gn:BSU08540" /db_xref="EnsemblGenomes-Tr:CAB12683" /db_xref="GOA:O31577" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12884" /db_xref="UniProtKB/Swiss-Prot:O31577" /translation="MSIKNPSVKFIIFVLMICTFSIGYTEYAVMGILTSIANDFHIQV SSAGLLVTAYAASVCLTGPLVTIISVKLPRKPVLLGLMAIFILSNLMSALAPNFAVLA ISRILSASIHGAFFAIAMVFASEMVPPEKRAAAAASMNGGLTVALMLGVPFGSYLGDV LNWRAVFSIITALGVIGFLGLMAAVPNRKPKVIPMLMNEWGVFKHKQVLFSFAITILG YSGVFIAYTFIEPILRHSAGFSTVGITGALFAYGLGGVAGNFFAGKVPLPLLTRTMIG VMIGLIGVLAVFPYIAIYPAAAIVATFLFGACAFGTPPLLQTKVISSSEGGTTIAAAV SVSAFNLANALGAWIGGMILNGTGSYSWLFAGGALMTACGLVLSTFAHLSEKKSVYEY QVNKG*" /label="yfhI CDS" gene 876463..877656 /gene="yfhI" /locus_tag="BSU_08540" /old_locus_tag="BSU08540" /label="yfhI gene" S_feature 877657..877891 /Source="Nicolas_S_feature" /locus_tag="new_928080_928314" /HighExp="G180, Paraq, C30, Oxctl, H2O2, G135, G150, S8, Heat, LBGstat" /AntisenseName="sspK" /AntisenseCor="1.9886505145521101E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S290" CDS complement(877689..877841) /gene="sspK" /locus_tag="BSU_08550" /old_locus_tag="BSU08550" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10806362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10806362; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="YP_054573.1" /db_xref="EnsemblGenomes-Gn:BSU08550" /db_xref="EnsemblGenomes-Tr:CAE01449" /db_xref="GOA:Q7WY75" /db_xref="InterPro:IPR012611" /db_xref="SubtiList:BG14175" /db_xref="UniProtKB/Swiss-Prot:Q7WY75" /translation="MVRNKEKGFPYENENKFQGEPRAKDDYASKRADGSINQHPQERM RASGKR*" /label="sspK CDS" gene complement(877689..877841) /gene="sspK" /locus_tag="BSU_08550" /old_locus_tag="BSU08550" /label="sspK gene" downshifts complement(877706) /Source="Nicolas_upshifts" /id="D425" /incds=0 /nref=24 /ntot=45 /MaxReadThrough="2.36419" /MaxDrop="4.9889" /score="20.2715496" /energy="-12.3" /TU="NA" /idTUdmin="U652" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 877870..877877 /Source="Nicolas_upshift_promotors" /id="U651" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.924075924075924" /psig="0.995004995004995" /xcortree=2031 /SigmaFactorBS="tcggaccatgtcatatccccctaggttcgagatcaaaAAGTT GCGtcttttcagatgaAGACGTAAGGTTAGTATATGgagaacaccacgtaataaagcg t" /listShort="S291, yfhJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 877891..877910 /Source="Nicolas_upshift_promotors" /id="U651" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.924075924075924" /psig="0.995004995004995" /xcortree=2031 /SigmaFactorBS="tcggaccatgtcatatccccctaggttcgagatcaaaAAGTT GCGtcttttcagatgaAGACGTAAGGTTAGTATATGgagaacaccacgtaataaagcg t" /listShort="S291, yfhJ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 877893..877965 /Source="Nicolas_S_feature" /locus_tag="new_928316_928388" /HighExp="dia5, LPhT, Diami, dia15, Etha, T0.30H, H2O2, LBGstat, BC, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.995, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S291" upshifts 877893 /Source="Nicolas_upshifts" /id="U651" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.924075924075924" /psig="0.995004995004995" /xcortree=2031 /SigmaFactorBS="tcggaccatgtcatatccccctaggttcgagatcaaaAAGTT GCGtcttttcagatgaAGACGTAAGGTTAGTATATGgagaacaccacgtaataaagcg t" /listShort="S291, yfhJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(877900..877911) /Source="Nicolas_upshift_promotors" /id="U652" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=867 /SigmaFactorBS="ttcatgtgtgcagtctcctttcttcaggaaaaaaataaCGCT TTAttacgtggtgttctCCATATACTAACcttacgtcttcatctgaaaagacgcaact t" /listShort="sspK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(877910) /Source="Nicolas_upshifts" /id="U652" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=867 /SigmaFactorBS="ttcatgtgtgcagtctcctttcttcaggaaaaaaataaCGCT TTAttacgtggtgttctCCATATACTAACcttacgtcttcatctgaaaagacgcaact t" /listShort="sspK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(877926..877932) /Source="Nicolas_upshift_promotors" /id="U652" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=867 /SigmaFactorBS="ttcatgtgtgcagtctcctttcttcaggaaaaaaataaCGCT TTAttacgtggtgttctCCATATACTAACcttacgtcttcatctgaaaagacgcaact t" /listShort="sspK" /GFF_Attribute="listLong" /label="promotor_-35" CDS 877966..878235 /gene="yfhJ" /locus_tag="BSU_08560" /old_locus_tag="BSU08560" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388736.1" /db_xref="EnsemblGenomes-Gn:BSU08560" /db_xref="EnsemblGenomes-Tr:CAB12684" /db_xref="InterPro:IPR026952" /db_xref="SubtiList:BG12885" /db_xref="UniProtKB/Swiss-Prot:O31578" /translation="MNMYIEKLTNLLLEKNEMISYIQAKTWVELLWSDFEATYAKAGH AYQGEKMTEKIVTQWIENYGGQLHLFQSSRNDVNDYLNQSRGLLH*" /label="yfhJ CDS" gene 877966..878235 /gene="yfhJ" /locus_tag="BSU_08560" /old_locus_tag="BSU08560" /label="yfhJ gene" downshifts 878224 /Source="Nicolas_upshifts" /id="D426" /incds=0 /nref=62 /ntot=233 /MaxReadThrough="2.9538" /MaxDrop="5.3621" /score="19.3423239" /energy="-10.6" /TU="NA" /idTUdmin="U650" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 878313..878319 /Source="Nicolas_upshift_promotors" /id="U653" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=223 /SigmaFactorBS="ttaaaattaccttaacaggaagaaatcataaacaaaacaTGT TTCAccagcctgtcaatcaGGGAATACCACTTATATCTtgtcaaaatgcgaggaggag c" /listShort="yfhK, S292, yfhL, yfhM, S293, S294, csbB, S295, yfhO" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 878334 /Source="Nicolas_upshifts" /id="U653" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=223 /SigmaFactorBS="ttaaaattaccttaacaggaagaaatcataaacaaaacaTGT TTCAccagcctgtcaatcaGGGAATACCACTTATATCTtgtcaaaatgcgaggaggag c" /listShort="yfhK, S292, yfhL, yfhM, S293, S294, csbB, S295, yfhO" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 878335..878353 /Source="Nicolas_upshift_promotors" /id="U653" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=223 /SigmaFactorBS="ttaaaattaccttaacaggaagaaatcataaacaaaacaTGT TTCAccagcctgtcaatcaGGGAATACCACTTATATCTtgtcaaaatgcgaggaggag c" /listShort="yfhK, S292, yfhL, yfhM, S293, S294, csbB, S295, yfhO" /GFF_Attribute="listLong" /label="promotor_-10" CDS 878380..878898 /gene="yfhK" /locus_tag="BSU_08570" /old_locus_tag="BSU08570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_388737.1" /db_xref="EnsemblGenomes-Gn:BSU08570" /db_xref="EnsemblGenomes-Tr:CAB12685" /db_xref="InterPro:IPR003646" /db_xref="SubtiList:BG12886" /db_xref="UniProtKB/Swiss-Prot:O31579" /translation="MKKKQVMLALTAAAGLGLTALHSAPAAKAAPLHDISVSMPSSDT YIIKAGKLNVRTEPNHEGDILGTVSSEQKVKVDRFVNADWAQIHFKGKKAYISTHFLM KTASQAKTTKQTAFYTPTPENGKAKQLSSGTEVTILGWGFSENGGFDFTWAFVDYGGV KGYIHTKDLQMR*" /label="yfhK CDS" gene 878380..878898 /gene="yfhK" /locus_tag="BSU_08570" /old_locus_tag="BSU08570" /label="yfhK gene" S_feature 878899..878966 /Source="Nicolas_S_feature" /locus_tag="new_929322_929389" /HighExp="Etha, Sw, Salt, M9-stat, B60, B36, Gly, LoTm, BC, LPhT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S292" promotor_-35 878934..878943 /Source="Nicolas_upshift_promotors" /id="U654" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1692 /SigmaFactorBS="ccgaggcttgtctttttgcctatgcaTGAAACATTTcttctt tctgcACGTAACAATGAGAAAggagatgatgatatgacgggtttagtcggcggagggc t" /listShort="yfhL, yfhM" /listLong="S293, S294, csbB, S295, yfhO" /label="promotor_-35" promotor_-10 878955..878970 /Source="Nicolas_upshift_promotors" /id="U654" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1692 /SigmaFactorBS="ccgaggcttgtctttttgcctatgcaTGAAACATTTcttctt tctgcACGTAACAATGAGAAAggagatgatgatatgacgggtttagtcggcggagggc t" /listShort="yfhL, yfhM" /listLong="S293, S294, csbB, S295, yfhO" /label="promotor_-10" upshifts 878968 /Source="Nicolas_upshifts" /id="U654" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1692 /SigmaFactorBS="ccgaggcttgtctttttgcctatgcaTGAAACATTTcttctt tctgcACGTAACAATGAGAAAggagatgatgatatgacgggtttagtcggcggagggc t" /listShort="yfhL, yfhM" /listLong="S293, S294, csbB, S295, yfhO" /label="upshifts" CDS 878983..879315 /gene="spdL" /locus_tag="BSU_08580" /old_locus_tag="BSU08580" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16629676, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16629676, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor for peptide SdpC immunity" /protein_id="NP_388738.1" /db_xref="EnsemblGenomes-Gn:BSU08580" /db_xref="EnsemblGenomes-Tr:CAB12686" /db_xref="GOA:O31580" /db_xref="InterPro:IPR025962" /db_xref="SubtiList:BG12887" /db_xref="UniProtKB/Swiss-Prot:O31580" /translation="MTGLVGGGLMIIAGILIKLFPPKSINSVYGYRTRRSMSDQRLWN EANRYSASLMILSGLVIAGMGLLLGSNLFILQLILLIAACVITFMLTEKRLKIMTHSQ GGDRSGRS*" /label="spdL CDS" gene 878983..879315 /gene="spdL" /locus_tag="BSU_08580" /old_locus_tag="BSU08580" /label="spdL gene" CDS 879302..880162 /gene="ephM" /locus_tag="BSU_08590" /old_locus_tag="BSU08590" /EC_number="3.3.2.10" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16597997, 20941576" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16597997, 20941576; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="stress induced epoxide hydrolase" /protein_id="NP_388739.1" /db_xref="EnsemblGenomes-Gn:BSU08590" /db_xref="EnsemblGenomes-Tr:CAB12687" /db_xref="GOA:O31581" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR000639" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12888" /db_xref="UniProtKB/Swiss-Prot:O31581" /translation="MDGVKCQFVNTNGITLHVAAAGREDGPLIVLLHGFPEFWYGWKN QIKPLVDAGYRVIAPDQRGYNLSDKPEGIDSYRIDTLRDDIIGLITQFTDEKAIVIGH DWGGAVAWHLASTRPEYLEKLIAINIPHPHVMKTVTPLYPPQWLKSSYIAYFQLPDIP EASLRENDYDTLDKAIGLSDRPALFTSEDVSRYKEAWKQPGALTAMLNWYRALRKGSL AEKPSYETVPYRMIWGMEDRFLSRKLAKETERHCPNGHLIFVDEASHWINHEKPAIVN QLILEYLKNQ*" /label="ephM CDS" gene 879302..880162 /gene="ephM" /locus_tag="BSU_08590" /old_locus_tag="BSU08590" /label="ephM gene" downshifts 880160 /Source="Nicolas_upshifts" /id="D427" /incds=0 /nref=27 /ntot=191 /MaxReadThrough="5.0793" /MaxDrop="4.1326" /score="3.7712168" /energy="-8.4" /TU="U653,U654" /idTUdmin="U654" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" promotor_-35 880220..880226 /Source="Nicolas_upshift_promotors" /id="U655" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=945 /SigmaFactorBS="tcataatggcagactttttctgtgcgttttttTTCATAGtct gttttaaacaTGACAAAATAACattaaaaatcatgaatgtcaccataaaattgtaaca a" /listShort="S293, S294, csbB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 880240..880251 /Source="Nicolas_upshift_promotors" /id="U655" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=945 /SigmaFactorBS="tcataatggcagactttttctgtgcgttttttTTCATAGtct gttttaaacaTGACAAAATAACattaaaaatcatgaatgtcaccataaaattgtaaca a" /listShort="S293, S294, csbB" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 880248..880312 /Source="Nicolas_S_feature" /locus_tag="new_930671_930735" /HighExp="Etha, S5, M9-stat, T0.30H, Sw, T-0.40H, B60, S8, B36, T1.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigB" /TUshortPSig="0.99, 1" /TUlongSig="SigWXY" /TUlongPSig=1 /label="S293" upshifts 880248 /Source="Nicolas_upshifts" /id="U655" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=945 /SigmaFactorBS="tcataatggcagactttttctgtgcgttttttTTCATAGtct gttttaaacaTGACAAAATAACattaaaaatcatgaatgtcaccataaaattgtaaca a" /listShort="S293, S294, csbB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(880270..880289) /Source="Nicolas_upshift_promotors" /id="U656" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.446553446553447" /psig="0.97902097902098" /xcortree=2407 /SigmaFactorBS="caaatcttcagtaaggctattcctttttttaaagtCGtttaa acctgtttTTTGTTACAATTTTATGGTGacattcatgatttttaatgttattttgtca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(880279) /Source="Nicolas_upshifts" /id="U656" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.446553446553447" /psig="0.97902097902098" /xcortree=2407 /SigmaFactorBS="caaatcttcagtaaggctattcctttttttaaagtCGtttaa acctgtttTTTGTTACAATTTTATGGTGacattcatgatttttaatgttattttgtca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 880295..880301 /Source="Nicolas_upshift_promotors" /id="U657" /multdbtbs="SigB,SigX" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=124 /SigmaFactorBS="taaaaatcatgaatgtcaccataaaattgtaacaaaaaacaG GTTTAAacgactttaaaaaaAGGAATAGCCTTACTGAAGatttgtgtaaaactcccct a" /listShort="S294, csbB, S295, yfhO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(880303..880304) /Source="Nicolas_upshift_promotors" /id="U656" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.446553446553447" /psig="0.97902097902098" /xcortree=2407 /SigmaFactorBS="caaatcttcagtaaggctattcctttttttaaagtCGtttaa acctgtttTTTGTTACAATTTTATGGTGacattcatgatttttaatgttattttgtca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 880314..880394 /Source="Nicolas_S_feature" /locus_tag="new_930737_930817" /HighExp="M9-stat, LBGexp, Lbexp, T0.30H, dia0, T1.30H, T1.0H, LBGtran, Paraq, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigGF, SigB" /TUshortPSig="1, 0.99, 1" /TUlongSig="SigWXY" /TUlongPSig=1 /label="S294" upshifts 880314 /Source="Nicolas_upshifts" /id="U657" /multdbtbs="SigB,SigX" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=124 /SigmaFactorBS="taaaaatcatgaatgtcaccataaaattgtaacaaaaaacaG GTTTAAacgactttaaaaaaAGGAATAGCCTTACTGAAGatttgtgtaaaactcccct a" /listShort="S294, csbB, S295, yfhO" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 880316..880334 /Source="Nicolas_upshift_promotors" /id="U657" /multdbtbs="SigB,SigX" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=124 /SigmaFactorBS="taaaaatcatgaatgtcaccataaaattgtaacaaaaaacaG GTTTAAacgactttaaaaaaAGGAATAGCCTTACTGAAGatttgtgtaaaactcccct a" /listShort="S294, csbB, S295, yfhO" /GFF_Attribute="listLong" /label="promotor_-10" CDS 880395..881384 /gene="csbB" /locus_tag="BSU_08600" /old_locus_tag="BSU08600" /EC_number="2.4.-.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8921856, 9636707, 23632331; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative bactoprenol glycosyl transferase, phageorigin" /protein_id="NP_388740.1" /db_xref="EnsemblGenomes-Gn:BSU08600" /db_xref="EnsemblGenomes-Tr:CAB12688" /db_xref="GOA:Q45539" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG11834" /db_xref="UniProtKB/Swiss-Prot:Q45539" /translation="MKQGLISIIIPSYNEGYNVKLIHESLKKEFKNIHYDYEIFFIND GSVDDTLQQIKDLAATCSRVKYISFSRNFGKEAAILAGFEHVQGEAVIVMDADLQHPT YLLKEFIKGYEEGYDQVIAQRNRKGDSFVRSLLSSMYYKFINKAVEVDLRDGVGDFRL LSRQAVNALLKLSEGNRFSKGLFCWIGFDQKIVFYENVERKNGTSKWSFSSLFNYGMD GVVSFNHKPLRLCFYTGIFILLLSIIYIIATFVKILTNGISVPGYFTIISAVLFLGGV QLLSLGIIGEYIGRIYYETKKRPHYLIKEANIPNKDLPETNELKSMRRLTKMH*" /label="csbB CDS" gene 880395..881384 /gene="csbB" /locus_tag="BSU_08600" /old_locus_tag="BSU08600" /label="csbB gene" upshifts complement(880544) /Source="Nicolas_upshifts" /id="U658" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.712287712287712" /psig="0.037962037962038" /xcortree=125 /SigmaFactorBS="agaaaaagatatatattttacccggctgcaCGTCGctgccaa gtctttgatCTGCTgaagcgtgtcatcaacacttccgtcgtttatgaagaatatttca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(880549..880553) /Source="Nicolas_upshift_promotors" /id="U658" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.712287712287712" /psig="0.037962037962038" /xcortree=125 /SigmaFactorBS="agaaaaagatatatattttacccggctgcaCGTCGctgccaa gtctttgatCTGCTgaagcgtgtcatcaacacttccgtcgtttatgaagaatatttca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(880570..880574) /Source="Nicolas_upshift_promotors" /id="U658" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.712287712287712" /psig="0.037962037962038" /xcortree=125 /SigmaFactorBS="agaaaaagatatatattttacccggctgcaCGTCGctgccaa gtctttgatCTGCTgaagcgtgtcatcaacacttccgtcgtttatgaagaatatttca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 881385..881455 /Source="Nicolas_S_feature" /locus_tag="new_931808_931878" /HighExp="LPhT, Heat, Etha, LBGexp, M9-stat, LBGtran, Lbexp, Sw, dia0, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigB" /TUshortPSig="1, 1" /TUlongSig="SigWXY" /TUlongPSig=1 /label="S295" CDS 881456..884041 /gene="yfhO" /locus_tag="BSU_08610" /old_locus_tag="BSU08610" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23632331; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="conserved membrane protein" /protein_id="NP_388741.2" /db_xref="EnsemblGenomes-Gn:BSU08610" /db_xref="EnsemblGenomes-Tr:CAB12689" /db_xref="GOA:O31582" /db_xref="InterPro:IPR018580" /db_xref="SubtiList:BG12889" /db_xref="UniProtKB/Swiss-Prot:O31582" /translation="MKRKHIMIYAASLLVSVLAHAFFVKEWAEGRYMTGPGDGLAQMI VFKKLLFDQYTHGNFFYNYSFGLGGGTFSQLGYYFSASFLFLAVSAAVWLLQAVQLIG ETDTLFWAESAVFISIFKLSLIIFTSASVFHYLLKHRAASFTGAVLYGVSIIYFRHEA YWEFFTDTMVWLPLLVLGAEKIIRERRPAWFIVACSLTLINNFYFAYINLIFIGIYVL FRWLIRLEPHEEKRWIQIRLFLVSGFISFGISAAAFVPVVYGFLNNLRPPYSQKIEWL NFDDNILFSSRIIIVPAAFLLFLFIISFYKNRVFRLFAGLSLLFILFHFSPYAASVFN GFSAPQNRFEYVLAFTIAGAAAAGLSQLSELKRKELLPAAAVVLLLYLYHIQRYKLDI WKPANESILLLLLMTIAALFAAAFAKKRAKMAVYGIIILSSLFVANSYQKYALSEGGD LDSVTKEYLTSEEYRGRESSELIRRLQKEDDDPLMRIDWMNGVRNNTPIIYGFNGFSA YSSILNKDLLAFYWNDLSIDMGRESVSRYASLGDRANLYSLLYGKYYMTEKTNEASVP YGFKKHLETEHYAVYENQYMLPFVKTADAIYSESELDRLPALAKEQAMLKGIILKDPS GKTEQTPKPSNLITKSDITAKQAQYQNGLLTVTGENGGELIITPKQPSSAPGDYYVSF YLKSKAKDKGFTLKVNDYVTTRKSNKSIYKTGVNNITVRVPKSGHISINLPKGTYELR NIALYEENYQTLKNAVMQNKTEKADKLNWNKNRLTFSYHLSKDQYIMLPIPYEKGWEL KINGKTQKIEKADYAFIGFKAQKGDNHIELTYYPPYFKISAIISLVSLLLAVFYIRRK KPGSI*" /label="yfhO CDS" gene 881456..884041 /gene="yfhO" /locus_tag="BSU_08610" /old_locus_tag="BSU08610" /label="yfhO gene" downshifts 884010 /Source="Nicolas_upshifts" /id="D428" /incds=0 /nref=63 /ntot=217 /MaxReadThrough="2.13267" /MaxDrop="4.17784" /score="2.41489488" /energy="-13.3" /TU="NA" /idTUdmin="U657" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(884034..885017) /gene="yfhP" /locus_tag="BSU_08620" /old_locus_tag="BSU08620" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10463184, 10524235, 15849754, 16850406, 24237659; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane hydrolase" /protein_id="NP_388742.1" /db_xref="EnsemblGenomes-Gn:BSU08620" /db_xref="EnsemblGenomes-Tr:CAB12690" /db_xref="GOA:O31583" /db_xref="InterPro:IPR007404" /db_xref="SubtiList:BG12890" /db_xref="UniProtKB/Swiss-Prot:O31583" /translation="MDTGTHVVMGIALGGIATLDPVVGSDPAMAHAVMIATLAGSQAP DIDTVLKLKNNAVYIRNHRGFTHSIPAVLFWSVIIPAILYLFYPQADFLHLWLWTLLA VVLHVFVDIFNAYGTQAIRPFSKKWVALGLINTFDPFIFISHLAAIAIWYAGGSPGIT FLSLYIILVGYYLVRLIMQLRIKRKLHEMIHDEIESIIISPTMKFRQWRIAVTTAHAF YVGRSMEGHVVILDTFNRVPVPETDVMHAAKQDDNIAAFLSFSPVYRWEVDTFKDHYE VRFIDLRYRSKGHYPFVAIVHIGHDLTIRSSYTGWIFSEEKLQKKLKLGSI*" /label="yfhP CDS" gene complement(884034..885017) /gene="yfhP" /locus_tag="BSU_08620" /old_locus_tag="BSU08620" /label="yfhP gene" downshifts complement(884068) /Source="Nicolas_upshifts" /id="D429" /incds=0 /nref=28 /ntot=200 /MaxReadThrough="2.65266" /MaxDrop="4.43244" /score="25.5564412" /energy="-17.5" /TU="NA" /idTUdmin="U661" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" promotor_-35 884491..884500 /Source="Nicolas_upshift_promotors" /id="U659" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1381 /SigmaFactorBS="atgaagcttccgtttaattctcagctgcatgatcAGGCGCAC CAagtagtagcctaCCAATATGATATATAAGCTGagaaacgtgatgccgggactcccg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 884513..884532 /Source="Nicolas_upshift_promotors" /id="U659" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1381 /SigmaFactorBS="atgaagcttccgtttaattctcagctgcatgatcAGGCGCAC CAagtagtagcctaCCAATATGATATATAAGCTGagaaacgtgatgccgggactcccg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 884517 /Source="Nicolas_upshifts" /id="U659" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1381 /SigmaFactorBS="atgaagcttccgtttaattctcagctgcatgatcAGGCGCAC CAagtagtagcctaCCAATATGATATATAAGCTGagaaacgtgatgccgggactcccg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(885018..885165) /Source="Nicolas_S_feature" /locus_tag="new_935441_935588_c" /HighExp="Diami, dia15, M9-stat, dia5, Etha, H2O2, S6, Salt, Lbtran, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S296" promotor_-35 885122..885126 /Source="Nicolas_upshift_promotors" /id="U660" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.718281718281718" /psig="0.998001998001998" /xcortree=2674 /SigmaFactorBS="tttaaactgattcaatcgttctcatatgtttccGCTTTttct ttattactattTAATGTAACATATTATCGTActgtgcccttagtgtacaacaaaaaac a" /listShort="S297, yfhQ, S298, fabL, sspE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 885142..885161 /Source="Nicolas_upshift_promotors" /id="U660" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.718281718281718" /psig="0.998001998001998" /xcortree=2674 /SigmaFactorBS="tttaaactgattcaatcgttctcatatgtttccGCTTTttct ttattactattTAATGTAACATATTATCGTActgtgcccttagtgtacaacaaaaaac a" /listShort="S297, yfhQ, S298, fabL, sspE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 885149 /Source="Nicolas_upshifts" /id="U660" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.718281718281718" /psig="0.998001998001998" /xcortree=2674 /SigmaFactorBS="tttaaactgattcaatcgttctcatatgtttccGCTTTttct ttattactattTAATGTAACATATTATCGTActgtgcccttagtgtacaacaaaaaac a" /listShort="S297, yfhQ, S298, fabL, sspE" /GFF_Attribute="listLong" /label="upshifts" S_feature 885155..885232 /Source="Nicolas_S_feature" /locus_tag="new_935578_935655" /HighExp="H2O2, G150, G180, LBGstat, dia15, Diami, Oxctl, Paraq, G135, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S297" promotor_-10 complement(885163..885182) /Source="Nicolas_upshift_promotors" /id="U661" /multdbtbs="SigK,SigK" /comp="M19" /sig="SigA" /pcomp="0.875124875124875" /psig="0.997002997002997" /xcortree=643 /SigmaFactorBS="tctccccagtctttcgcgcccCGCTTTTCtttagactgtttt tTGTTGTACACTAAGGGCACAgtacgataatatgttacattaaatagtaataaagaaa a" /listShort="S296, yfhP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(885165) /Source="Nicolas_upshifts" /id="U661" /multdbtbs="SigK,SigK" /comp="M19" /sig="SigA" /pcomp="0.875124875124875" /psig="0.997002997002997" /xcortree=643 /SigmaFactorBS="tctccccagtctttcgcgcccCGCTTTTCtttagactgtttt tTGTTGTACACTAAGGGCACAgtacgataatatgttacattaaatagtaataaagaaa a" /listShort="S296, yfhP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(885197..885204) /Source="Nicolas_upshift_promotors" /id="U661" /multdbtbs="SigK,SigK" /comp="M19" /sig="SigA" /pcomp="0.875124875124875" /psig="0.997002997002997" /xcortree=643 /SigmaFactorBS="tctccccagtctttcgcgcccCGCTTTTCtttagactgtttt tTGTTGTACACTAAGGGCACAgtacgataatatgttacattaaatagtaataaagaaa a" /listShort="S296, yfhP" /GFF_Attribute="listLong" /label="promotor_-35" CDS 885233..886342 /gene="mutY" /locus_tag="BSU_08630" /old_locus_tag="BSU08630" /EC_number="3.2.2.-" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10463184, 20971907, 21954439, 27399782" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10463184, 20971907, 21954439, 27399782; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="A/G-specific adenine glycosylase or DNA-(apurinic or apyrimidinic site) lyase" /protein_id="NP_388743.1" /db_xref="EnsemblGenomes-Gn:BSU08630" /db_xref="EnsemblGenomes-Tr:CAB12691" /db_xref="GOA:O31584" /db_xref="InterPro:IPR003265" /db_xref="InterPro:IPR003651" /db_xref="InterPro:IPR005760" /db_xref="InterPro:IPR011257" /db_xref="InterPro:IPR015797" /db_xref="InterPro:IPR023170" /db_xref="InterPro:IPR029119" /db_xref="SubtiList:BG12891" /db_xref="UniProtKB/Swiss-Prot:O31584" /translation="MNVLEDKLKQKDIQQFRDDLISWFEREQRVLPWREDQDPYKVWV SEVMLQQTRVETVIPYFLRFVEQFPTVEALADADEEKVLKAWEGLGYYSRVRNLQSAV KEVKQEYGGIVPPDEKDFGGLKGVGPYTKGAVLSIAYNKPIPAVDGNVMRVMSRILSI WDDIAKPKTRTIFEDAIRAFISKEKPSEFNQGLMELGALICTPKSPSCLLCPVQQHCS AFEEGTERELPVKSKKKKPGIKTMAAIVLTDEDGQVYIHKRPSKGLLANLWEFPNLET QKGIKTEREQLIAFLENEYGIQADISDLQGVVEHVFTHLVWNISVFFGKVKQVSDTSK LKKVTKEELEQFAFPVSHQKIWKMAGEAAAISAAP*" /label="mutY CDS" gene 885233..886342 /gene="mutY" /locus_tag="BSU_08630" /old_locus_tag="BSU08630" /label="mutY gene" promotor_-35 886179..886183 /Source="Nicolas_upshift_promotors" /id="U662" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.556443556443556" /psig="0.997002997002997" /xcortree=2563 /SigmaFactorBS="gtagtcgagcatgttttcacccacctggTATGGaatatttca gtgtttTTCGGTAAAGTAAAACAAGTgtcggataccagcaagctgaaaaaagtaacga a" /listShort="S298, fabL, sspE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 886199..886218 /Source="Nicolas_upshift_promotors" /id="U662" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.556443556443556" /psig="0.997002997002997" /xcortree=2563 /SigmaFactorBS="gtagtcgagcatgttttcacccacctggTATGGaatatttca gtgtttTTCGGTAAAGTAAAACAAGTgtcggataccagcaagctgaaaaaagtaacga a" /listShort="S298, fabL, sspE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 886211 /Source="Nicolas_upshifts" /id="U662" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.556443556443556" /psig="0.997002997002997" /xcortree=2563 /SigmaFactorBS="gtagtcgagcatgttttcacccacctggTATGGaatatttca gtgtttTTCGGTAAAGTAAAACAAGTgtcggataccagcaagctgaaaaaagtaacga a" /listShort="S298, fabL, sspE" /GFF_Attribute="listLong" /label="upshifts" S_feature 886343..886655 /Source="Nicolas_S_feature" /locus_tag="new_936766_937078" /HighExp="H2O2, G150, dia15, G135, G180, Oxctl, Paraq, dia0, LBGexp, Lbexp" /AntisenseName="yfhS" /AntisenseCor="-0.72611377663365595" /AntisenseRegPval="-44.6" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S298" CDS complement(886350..886574) /gene="yfhS" /locus_tag="BSU_08640" /old_locus_tag="BSU08640" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 10463184" /codon_start=1 /transl_table=11 /product="conserved protein related to sporulation" /protein_id="NP_388744.1" /db_xref="EnsemblGenomes-Gn:BSU08640" /db_xref="EnsemblGenomes-Tr:CAB12692" /db_xref="SubtiList:BG12892" /db_xref="UniProtKB/Swiss-Prot:O31585" /translation="MYVGRDMSELNMVSKKDWKNSELAYFHHAFQQIMPYLNEEGQSK YRELTQEIEARGGMKRNEADYSHGTRVSYD*" /label="yfhS CDS" gene complement(886350..886574) /gene="yfhS" /locus_tag="BSU_08640" /old_locus_tag="BSU08640" /label="yfhS gene" promotor_-10 complement(886604..886615) /Source="Nicolas_upshift_promotors" /id="U663" /multdbtbs="SigE" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=858 /SigmaFactorBS="ttttgttccatttttcctcatctccttgtagCGTATAGttct tttatttccACAAACAATAATggcaagaactttaaagggggtcttctgttatgtatgt c" /listShort="yfhS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(886606) /Source="Nicolas_upshifts" /id="U663" /multdbtbs="SigE" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=858 /SigmaFactorBS="ttttgttccatttttcctcatctccttgtagCGTATAGttct tttatttccACAAACAATAATggcaagaactttaaagggggtcttctgttatgtatgt c" /listShort="yfhS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(886629..886635) /Source="Nicolas_upshift_promotors" /id="U663" /multdbtbs="SigE" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=858 /SigmaFactorBS="ttttgttccatttttcctcatctccttgtagCGTATAGttct tttatttccACAAACAATAATggcaagaactttaaagggggtcttctgttatgtatgt c" /listShort="yfhS" /GFF_Attribute="listLong" /label="promotor_-35" CDS 886656..887408 /gene="fabL" /locus_tag="BSU_08650" /old_locus_tag="BSU08650" /EC_number="1.3.1.10" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11007778, 12440970, 17329825, 21185310" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11007778, 12440970, 17329825, 21185310; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enoyl-acyl carrier protein reductase III" /protein_id="NP_388745.1" /db_xref="EnsemblGenomes-Gn:BSU08650" /db_xref="EnsemblGenomes-Tr:CAB12693" /db_xref="GOA:P71079" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR036291" /db_xref="PDB:3OIC" /db_xref="PDB:3OID" /db_xref="SubtiList:BG12221" /db_xref="UniProtKB/Swiss-Prot:P71079" /translation="MEQNKCALVTGSSRGVGKAAAIRLAENGYNIVINYARSKKAALE TAEEIEKLGVKVLVVKANVGQPAKIKEMFQQIDETFGRLDVFVNNAASGVLRPVMELE ETHWDWTMNINAKALLFCAQEAAKLMEKNGGGHIVSISSLGSIRYLENYTTVGVSKAA LEALTRYLAVELSPKQIIVNAVSGGAIDTDALKHFPNREDLLEDARQNTPAGRMVEIK DMVDTVEFLVSSKADMIRGQTIIVDGGRSLLV*" /label="fabL CDS" gene 886656..887408 /gene="fabL" /locus_tag="BSU_08650" /old_locus_tag="BSU08650" /label="fabL gene" promotor_-35 887425..887431 /Source="Nicolas_upshift_promotors" /id="U664" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=800 /SigmaFactorBS="cggacgctcactgctcgtttaaaaatttttaaaaaagaGGAA TAGctatacgatcacctGCACATTCTAATgaccgtggaggtgataacaatggctaact c" /listShort="sspE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 887446..887457 /Source="Nicolas_upshift_promotors" /id="U664" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=800 /SigmaFactorBS="cggacgctcactgctcgtttaaaaatttttaaaaaagaGGAA TAGctatacgatcacctGCACATTCTAATgaccgtggaggtgataacaatggctaact c" /listShort="sspE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 887447 /Source="Nicolas_upshifts" /id="U664" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=800 /SigmaFactorBS="cggacgctcactgctcgtttaaaaatttttaaaaaagaGGAA TAGctatacgatcacctGCACATTCTAATgaccgtggaggtgataacaatggctaact c" /listShort="sspE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(887454..887468) /Source="Nicolas_upshift_promotors" /id="U665" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.841158841158841" /psig="0.022977022977023" /xcortree=711 /SigmaFactorBS="tggttttgttttctaacttgttgagcgtttgttttgctgaag ttatttgagttaGCCATtgttatcaCCTCCACGGTCATTAgaatgtgcaggtgatcgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(887475) /Source="Nicolas_upshifts" /id="U665" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.841158841158841" /psig="0.022977022977023" /xcortree=711 /SigmaFactorBS="tggttttgttttctaacttgttgagcgtttgttttgctgaag ttatttgagttaGCCATtgttatcaCCTCCACGGTCATTAgaatgtgcaggtgatcgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(887477..887481) /Source="Nicolas_upshift_promotors" /id="U665" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.841158841158841" /psig="0.022977022977023" /xcortree=711 /SigmaFactorBS="tggttttgttttctaacttgttgagcgtttgttttgctgaag ttatttgagttaGCCATtgttatcaCCTCCACGGTCATTAgaatgtgcaggtgatcgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 887477..887731 /gene="sspE" /locus_tag="BSU_08660" /old_locus_tag="BSU08660" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1744043, 7592342, 9540829, 19542328, 23314362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1744043, 7592342, 9540829, 19542328, 23314362; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein (gamma-type SASP)" /protein_id="NP_388746.1" /db_xref="EnsemblGenomes-Gn:BSU08660" /db_xref="EnsemblGenomes-Tr:CAB12694" /db_xref="GOA:P07784" /db_xref="InterPro:IPR006341" /db_xref="SubtiList:BG10789" /db_xref="UniProtKB/Swiss-Prot:P07784" /translation="MANSNNFSKTNAQQVRKQNQQSAAGQGQFGTEFASETNAQQVRK QNQQSAGQQGQFGTEFASETDAQQVRQQNQSAEQNKQQNS*" /label="sspE CDS" gene 887477..887731 /gene="sspE" /locus_tag="BSU_08660" /old_locus_tag="BSU08660" /label="sspE gene" downshifts 887729 /Source="Nicolas_upshifts" /id="D430" /incds=0 /nref=261 /ntot=269 /MaxReadThrough="1.59207" /MaxDrop="8.74804" /score="9.25353719" /energy="-9.5" /TU="NA" /idTUdmin="U660" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(887754) /Source="Nicolas_upshifts" /id="D431" /incds=0 /nref=3 /ntot=21 /MaxReadThrough="1.21036" /MaxDrop="5.14076" /score="-9.78320441" /energy="-7.1" /TU="NA" /idTUdmin="U663" /TUdmin="-1687" /isTUend="FALSE" /label="downshifts" CDS 887820..888164 /gene="ygaB" /locus_tag="BSU_08670" /old_locus_tag="BSU08670" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388747.1" /db_xref="EnsemblGenomes-Gn:BSU08670" /db_xref="EnsemblGenomes-Tr:CAB12695" /db_xref="InterPro:IPR025572" /db_xref="SubtiList:BG12222" /db_xref="UniProtKB/Swiss-Prot:P71080" /translation="MSQRVCFMEIEMIKGGNVYTFIRLKEEPMTEFEKLVSEQMKTMD KLLDLQSELDRCKQIEAELRHLERDARLRGIQAEIAVKRKHLADIQDMFQKQTEQVIR SYRSSEKPSSFV*" /label="ygaB CDS" gene 887820..888164 /gene="ygaB" /locus_tag="BSU_08670" /old_locus_tag="BSU08670" /label="ygaB gene" promotor_-35 887827..887835 /Source="Nicolas_upshift_promotors" /id="U666" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=444 /SigmaFactorBS="aaaaacgacaaaacttgtggaaggtctacagaatgagtcAAA GGGTTTgctttatggaGATCGAAATGATTAAAGGAggaaatgtttatactttcatcag g" /listShort="ygaB, S299, ygaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 887846..887864 /Source="Nicolas_upshift_promotors" /id="U666" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=444 /SigmaFactorBS="aaaaacgacaaaacttgtggaaggtctacagaatgagtcAAA GGGTTTgctttatggaGATCGAAATGATTAAAGGAggaaatgtttatactttcatcag g" /listShort="ygaB, S299, ygaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 887848 /Source="Nicolas_upshifts" /id="U666" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=444 /SigmaFactorBS="aaaaacgacaaaacttgtggaaggtctacagaatgagtcAAA GGGTTTgctttatggaGATCGAAATGATTAAAGGAggaaatgtttatactttcatcag g" /listShort="ygaB, S299, ygaC" /GFF_Attribute="listLong" /label="upshifts" downshifts 888147 /Source="Nicolas_upshifts" /id="D432" /incds=0 /nref=1 /ntot=27 /MaxReadThrough="4.84572" /MaxDrop="3.29993" /score="13.9694142" /energy="-11.5" /TU="U666" /idTUdmin="U660" /TUdmin=418 /isTUend="FALSE" /label="downshifts" promotor_-35 888203..888210 /Source="Nicolas_upshift_promotors" /id="U667" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.641358641358641" /psig=1 /xcortree=2074 /SigmaFactorBS="tgtgccattccccggccggaatggctctttTATTTTCAtttt tcaatttgtAACGTTATAATAGGTAAAAGacgttgtcggtaagcaaatttggacatac t" /listShort="S299, ygaC, ygaD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 888224..888243 /Source="Nicolas_upshift_promotors" /id="U667" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.641358641358641" /psig=1 /xcortree=2074 /SigmaFactorBS="tgtgccattccccggccggaatggctctttTATTTTCAtttt tcaatttgtAACGTTATAATAGGTAAAAGacgttgtcggtaagcaaatttggacatac t" /listShort="S299, ygaC, ygaD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 888233..888307 /Source="Nicolas_S_feature" /locus_tag="new_938656_938730" /HighExp="Etha, dia15, dia5, Diami, Salt, H2O2, BC, T5.0H, Cold, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S299" upshifts 888233 /Source="Nicolas_upshifts" /id="U667" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.641358641358641" /psig=1 /xcortree=2074 /SigmaFactorBS="tgtgccattccccggccggaatggctctttTATTTTCAtttt tcaatttgtAACGTTATAATAGGTAAAAGacgttgtcggtaagcaaatttggacatac t" /listShort="S299, ygaC, ygaD" /GFF_Attribute="listLong" /label="upshifts" CDS 888308..888838 /gene="ygaC" /locus_tag="BSU_08680" /old_locus_tag="BSU08680" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 19383706, 22333191; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative RNA binding factor" /protein_id="NP_388748.3" /db_xref="EnsemblGenomes-Gn:BSU08680" /db_xref="EnsemblGenomes-Tr:CAB12696" /db_xref="InterPro:IPR007295" /db_xref="InterPro:IPR016882" /db_xref="InterPro:IPR035930" /db_xref="SubtiList:BG12223" /db_xref="UniProtKB/Swiss-Prot:Q796Z1" /translation="MGYPKEGETIQIHSYKHNGLIHRIWNETTILKSTEMCVIGANDR TMVTESDGRTWITREPAICYFHARQWFNVIGMLREDGVHYYCNISSPFAYDGEAIKYI DYDLDVKVFPDMTYNILDEDEYDDHRKAMNYPKEIDSILRDYLNTLLHWIHQRQGPFA PEFVDMWYERYLRYTK*" /label="ygaC CDS" gene 888308..888838 /gene="ygaC" /locus_tag="BSU_08680" /old_locus_tag="BSU08680" /label="ygaC gene" downshifts 888829 /Source="Nicolas_upshifts" /id="D433" /incds=0 /nref=8 /ntot=135 /MaxReadThrough="6.10669" /MaxDrop="3.97335" /score="-5.22328881" /energy="-7" /TU="U667" /idTUdmin="U666" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 888926..890668 /gene="ygaD" /locus_tag="BSU_08690" /old_locus_tag="BSU08690" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_388749.2" /db_xref="EnsemblGenomes-Gn:BSU08690" /db_xref="EnsemblGenomes-Tr:CAB12697" /db_xref="GOA:P71082" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG12224" /db_xref="UniProtKB/Swiss-Prot:P71082" /translation="MGVMKRYMQFVKPYKKQIFVTVLIGIVKFSIPLALPLLLKYVVD DIIQGGGTASDKTTSLFTIMAIMFALFLILRPPVEYYRQYFAQWTASKVLYDIRAKLF DHIQKLSLRFYANTRTGEVISRVINDVEQTKDFVITGLMNIWLDMLTILIVISIMLTL DVKLTLISIVLFPLYGISVKYFYGRLRKLTRERSQALAQVQGHLHERIQGMPVIRSFA IEDHEQAQFNEKNGHFLDKAIRHTNWNAKTFAVVNTITDLAPLIVIACAGYFVINGPL TVGTMVAFVGYIDRMYNPVRRLINSSTTLTQSIASMDRVFEFIDEPYELTDKPNAIKA DQIRGGVEFQNVSFQYEKDKENILHDVSLKVNRGETVALVGMSGGGKSTLVSLIPRFY DVTSGRLLIDGTDIRDYEARSLRNQVGMVLQDTFLFSETIRENIAIGKPDATLEEIIE AAKAANAHEFIMSFPEGYETRVGERGVKLSGGQKQRISIARVFLKNPPLLILDEATSA LDLESEHYIQEAMDKLAKDRTTFVVAHRLSTITHADKIVVMENGTIIEIGTHDELMDY ESQYKHLFTIQNLN*" /label="ygaD CDS" gene 888926..890668 /gene="ygaD" /locus_tag="BSU_08690" /old_locus_tag="BSU08690" /label="ygaD gene" downshifts 890655 /Source="Nicolas_upshifts" /id="D434" /incds=0 /nref=87 /ntot=233 /MaxReadThrough="2.54676" /MaxDrop="5.20475" /score="22.3853226" /energy="-14.1" /TU="NA" /idTUdmin="U667" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(890745..891806) /gene="ygaE" /locus_tag="BSU_08700" /old_locus_tag="BSU08700" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="NP_388750.1" /db_xref="EnsemblGenomes-Gn:BSU08700" /db_xref="EnsemblGenomes-Tr:CAB12698" /db_xref="GOA:P71083" /db_xref="InterPro:IPR010343" /db_xref="SubtiList:BG12225" /db_xref="UniProtKB/Swiss-Prot:P71083" /translation="MKLGARIFKTGIAITLALYLASWIGLPAPIFAGIAAIFAIQPSI YRSFLIIIDQVQANIIGAVIATVFGLIFGPSPIMIGLTAVIVITIMLKLKIEHTISIA LVTVIAILESAGDDFLMFALIRTSTVILGVLSSFIVNLVFLPPKYETKLIHNTVENTE EIMKWIRLSMRQSTEHSILKEDIEKLKEKMIKLDQTYLLYKEERSYFKKTTYVKSRKL VLFRQAIITANRALDTLKKLHRLENEIYHMPEEFQETLTEELDYLLYWHERILMRFVG KIKPHDDAVEEGIRYKQLLTKSFLKNQQNTDEELIDYNMLNIMASAVEYREQLEHLET LITSFQTYHPKDCEIETEE*" /label="ygaE CDS" gene complement(890745..891806) /gene="ygaE" /locus_tag="BSU_08700" /old_locus_tag="BSU08700" /label="ygaE gene" downshifts complement(890756) /Source="Nicolas_upshifts" /id="D435" /incds=0 /nref=181 /ntot=254 /MaxReadThrough="1.1413" /MaxDrop="7.13599" /score="26.0617552" /energy="-9.4" /TU="NA" /idTUdmin="U668" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" S_feature complement(891807..891897) /Source="Nicolas_S_feature" /locus_tag="new_942230_942320_c" /HighExp="G180, Oxctl, Paraq, C30, G150, LBGexp, LPhT, S4, G135, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S300" promotor_-10 complement(891895..891914) /Source="Nicolas_upshift_promotors" /id="U668" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.502497502497502" /psig="0.998001998001998" /xcortree=2441 /SigmaFactorBS="aagattttggtctttttctagaaaaataGCTTGAATatttgt atcgatccCTGTATATTACTTAATTGTTtagcaaataaactaaccgggaattttaagg a" /listShort="S300, ygaE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(891904) /Source="Nicolas_upshifts" /id="U668" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.502497502497502" /psig="0.998001998001998" /xcortree=2441 /SigmaFactorBS="aagattttggtctttttctagaaaaataGCTTGAATatttgt atcgatccCTGTATATTACTTAATTGTTtagcaaataaactaaccgggaattttaagg a" /listShort="S300, ygaE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(891929..891936) /Source="Nicolas_upshift_promotors" /id="U668" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.502497502497502" /psig="0.998001998001998" /xcortree=2441 /SigmaFactorBS="aagattttggtctttttctagaaaaataGCTTGAATatttgt atcgatccCTGTATATTACTTAATTGTTtagcaaataaactaaccgggaattttaagg a" /listShort="S300, ygaE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(892026..893315) /gene="gsaB" /locus_tag="BSU_08710" /old_locus_tag="BSU08710" /EC_number="5.4.3.8" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15231799, 19930658; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamate-1-semialdehyde aminotransferase, classIII aminotransferase" /protein_id="NP_388751.3" /db_xref="EnsemblGenomes-Gn:BSU08710" /db_xref="EnsemblGenomes-Tr:CAB12699" /db_xref="GOA:P71084" /db_xref="InterPro:IPR004639" /db_xref="InterPro:IPR005814" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG11943" /db_xref="UniProtKB/Swiss-Prot:P71084" /translation="MHTKSIELHNEALQHIVGGVNSPSRSYKAVGGGSPVAMEKASGA YFWDVDGNKYIDYLAAYGPIITGHAHPHITEAIKKAAENGVLYGTPTKHEVTFAKMLK EAIPAMDKVRFVNSGTEAVMTTIRVARAYTGRTKIIKFAGCYHGHSDLVLVAAGSGPS TLGTPDSAGVPKSIANEVITVPFNDIDSYKAALEKWGSEIAAVLVEPIVGNFGIVEPK EGFLEQVNELTHNAGALVIYDEVITAFRFMYGGAQDLLQVKPDLTALGKIIGGGLPIG AYGGKQEIMEQVAPLGPAYQAGTMAGNPASILSGIACLEVLKEKGVYEKLDHLGAMLE EGILKHAETHGITITVNRLKGALTVYFSDEKVENYEQAERSDGETFSTFFKLMLERGI NLAPSKYEAWFITTAHTEQDIKDTLTAVEDAFKHLKN*" /label="gsaB CDS" gene complement(892026..893315) /gene="gsaB" /locus_tag="BSU_08710" /old_locus_tag="BSU08710" /label="gsaB gene" downshifts complement(892029) /Source="Nicolas_upshifts" /id="D436" /incds=0 /nref=235 /ntot=258 /MaxReadThrough="2.54961" /MaxDrop="5.8522" /score="29.5551149" /energy="-11" /TU="NA" /idTUdmin="U669" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(893343..893362) /Source="Nicolas_upshift_promotors" /id="U669" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=1888 /SigmaFactorBS="tccagattacaaccatctcagctgaatctgaagcccgaagcc aTTGTTCttgttcggaagCATGCTACAATAGAAAGGACgcatggagatataggaggtt t" /listShort="gsaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(893362) /Source="Nicolas_upshifts" /id="U669" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=1888 /SigmaFactorBS="tccagattacaaccatctcagctgaatctgaagcccgaagcc aTTGTTCttgttcggaagCATGCTACAATAGAAAGGACgcatggagatataggaggtt t" /listShort="gsaB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(893364..894075) /Source="Nicolas_S_feature" /locus_tag="new_943787_944498_c" /HighExp="LoTm, M9-stat, B60, S8, C30, Cold, B36, T1.30H, Etha, T2.0H" /AntisenseName="ygaF" /AntisenseCor="-0.29702219161000198" /AntisenseRegPval="-6.2" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S301" promotor_-35 complement(893374..893379) /Source="Nicolas_upshift_promotors" /id="U669" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=1888 /SigmaFactorBS="tccagattacaaccatctcagctgaatctgaagcccgaagcc aTTGTTCttgttcggaagCATGCTACAATAGAAAGGACgcatggagatataggaggtt t" /listShort="gsaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 893408..893415 /Source="Nicolas_upshift_promotors" /id="U670" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig=1 /xcortree=2268 /SigmaFactorBS="aacaagaacaatggcttcgggcttcagattcagctgagaTGG TTGTAatctggacaagaaTTGGATACGCTTAATAAAAAaacatccggaggtaacgtaa t" /listShort="ygaF, perR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 893429..893448 /Source="Nicolas_upshift_promotors" /id="U670" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig=1 /xcortree=2268 /SigmaFactorBS="aacaagaacaatggcttcgggcttcagattcagctgagaTGG TTGTAatctggacaagaaTTGGATACGCTTAATAAAAAaacatccggaggtaacgtaa t" /listShort="ygaF, perR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 893429 /Source="Nicolas_upshifts" /id="U670" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig=1 /xcortree=2268 /SigmaFactorBS="aacaagaacaatggcttcgggcttcagattcagctgagaTGG TTGTAatctggacaagaaTTGGATACGCTTAATAAAAAaacatccggaggtaacgtaa t" /listShort="ygaF, perR" /GFF_Attribute="listLong" /label="upshifts" CDS 893468..893941 /gene="bcp" /locus_tag="BSU_08720" /old_locus_tag="BSU08720" /EC_number="1.11.1.15" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10644761, 11349039, 12950915, 21910476, 26723255; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peroxiredoxin with versatile activity" /protein_id="YP_054574.1" /db_xref="EnsemblGenomes-Gn:BSU08720" /db_xref="EnsemblGenomes-Tr:CAB12700" /db_xref="GOA:Q796Y8" /db_xref="InterPro:IPR000866" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR024706" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG12226" /db_xref="UniProtKB/Swiss-Prot:Q796Y8" /translation="MTIEIGQKAPDLELKGDHGETVKLSDYKGKYIVLYFYPKDMTPG CTTEACDFRDSHESFAELDAVIIGVSPDSQEKHGKFKEKHNLPFLLLVDDEHKLAEAF DVWKLKKNFGKEYMGIERSTFLIDKEGRLIKEWRKVKVKDHVAEALQTLKDMSEK*" /label="bcp CDS" gene 893468..893941 /gene="bcp" /locus_tag="BSU_08720" /old_locus_tag="BSU08720" /label="bcp gene" promotor_-35 893978..893985 /Source="Nicolas_upshift_promotors" /id="U671" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=1534 /SigmaFactorBS="ctatgagcctatgcttacttttaccctgatatCAATTGACaa attatcgtagaaAGAGTTACACTAATTATAAAcattacaatgtaagaattttttttag a" /listShort="perR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 894000..894019 /Source="Nicolas_upshift_promotors" /id="U671" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=1534 /SigmaFactorBS="ctatgagcctatgcttacttttaccctgatatCAATTGACaa attatcgtagaaAGAGTTACACTAATTATAAAcattacaatgtaagaattttttttag a" /listShort="perR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 894006 /Source="Nicolas_upshifts" /id="U671" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig=1 /xcortree=1534 /SigmaFactorBS="ctatgagcctatgcttacttttaccctgatatCAATTGACaa attatcgtagaaAGAGTTACACTAATTATAAAcattacaatgtaagaattttttttag a" /listShort="perR" /GFF_Attribute="listLong" /label="upshifts" CDS 894064..894501 /gene="perR" /locus_tag="BSU_08730" /old_locus_tag="BSU08730" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1580225, 16541078, 16925555, 22194458, 27935957, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1580225, 16541078, 16925555, 22194458, 27935957, 22720735; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (Fur family)" /protein_id="NP_388753.1" /db_xref="EnsemblGenomes-Gn:BSU08730" /db_xref="EnsemblGenomes-Tr:CAB12701" /db_xref="GOA:P71086" /db_xref="InterPro:IPR002481" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2FE3" /db_xref="PDB:2RGV" /db_xref="PDB:3F8N" /db_xref="SubtiList:BG12227" /db_xref="UniProtKB/Swiss-Prot:P71086" /translation="MAAHELKEALETLKETGVRITPQRHAILEYLVNSMAHPTADDIY KALEGKFPNMSVATVYNNLRVFRESGLVKELTYGDASSRFDFVTSDHYHAICENCGKI VDFHYPGLDEVEQLAAHVTGFKVSHHRLEIYGVCQECSKKENH*" /label="perR CDS" gene 894064..894501 /gene="perR" /locus_tag="BSU_08730" /old_locus_tag="BSU08730" /label="perR gene" downshifts 894483 /Source="Nicolas_upshifts" /id="D437" /incds=0 /nref=149 /ntot=247 /MaxReadThrough="3.98479" /MaxDrop="7.52234" /score="1.62878623" /energy="-12.3" /TU="U670,U671" /idTUdmin="U670" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" CDS complement(894536..894889) /gene="ygzB" /locus_tag="BSU_08740" /old_locus_tag="BSU08740" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="YP_054575.1" /db_xref="EnsemblGenomes-Gn:BSU08740" /db_xref="EnsemblGenomes-Tr:CAE01450" /db_xref="GOA:Q7WY74" /db_xref="InterPro:IPR020912" /db_xref="SubtiList:BG14192" /db_xref="UniProtKB/Swiss-Prot:Q7WY74" /translation="MAKYSSKINKIRTFALSLVFVGFIIMYIGIFFKESVLLSSLFMI LGLLSIGLSTVVYFWIGMLSTKAVRVICPGCDKETKVLGVVDMCMHCREPLTLDKGLE GKEFDESYNKKKMSK*" /label="ygzB CDS" gene complement(894536..894889) /gene="ygzB" /locus_tag="BSU_08740" /old_locus_tag="BSU08740" /label="ygzB gene" downshifts 894549 /Source="Nicolas_upshifts" /id="D438" /incds=0 /nref=1 /ntot=40 /MaxReadThrough="2.62283" /MaxDrop="4.13562" /score="-4.23596421" /energy="-12.5" /TU="NA" /idTUdmin="U670" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(894559) /Source="Nicolas_upshifts" /id="D439" /incds=0 /nref=182 /ntot=253 /MaxReadThrough="4.02571" /MaxDrop="6.23378" /score="9.51667757" /energy="-14.2" /TU="NA" /idTUdmin="U673" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 894885..894889 /Source="Nicolas_upshift_promotors" /id="U672" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.892107892107892" /psig="0.0739260739260739" /xcortree=2130 /SigmaFactorBS="ttaacgcaaatgttctgattttattaattttgctggagtatt tcGCCATgtccatcCCCCTCTGTTTTAACtatagcacaaacccgatgggattttcttc a" /listShort="S302, S303, ygxA" /listLong="S304, rrnD-16S" /label="promotor_-35" promotor_-10 894897..894911 /Source="Nicolas_upshift_promotors" /id="U672" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.892107892107892" /psig="0.0739260739260739" /xcortree=2130 /SigmaFactorBS="ttaacgcaaatgttctgattttattaattttgctggagtatt tcGCCATgtccatcCCCCTCTGTTTTAACtatagcacaaacccgatgggattttcttc a" /listShort="S302, S303, ygxA" /listLong="S304, rrnD-16S" /label="promotor_-10" misc_feature complement(894901..894920) /Source="Nicolas_upshift_promotors" /id="U673" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.949050949050949" /psig="0.998001998001998" /xcortree=432 /SigmaFactorBS="catatgtaaattccagttcaaccgaaaacatgaagaaaatcc catcgggttTGTGCTATAGTTAAAACAGAgggggatggacatggcgaaatactccagc a" /listShort="ygzB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 894901..894992 /Source="Nicolas_S_feature" /locus_tag="new_945324_945415" /HighExp="Cold, C30, H2O2, Etha, dia15, G135, Paraq, C90, G180, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.0739" /TUlongSig="NA" /TUlongPSig="NA" /label="S302" upshifts 894901 /Source="Nicolas_upshifts" /id="U672" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.892107892107892" /psig="0.0739260739260739" /xcortree=2130 /SigmaFactorBS="ttaacgcaaatgttctgattttattaattttgctggagtatt tcGCCATgtccatcCCCCTCTGTTTTAACtatagcacaaacccgatgggattttcttc a" /listShort="S302, S303, ygxA" /listLong="S304, rrnD-16S" /label="upshifts" upshifts complement(894911) /Source="Nicolas_upshifts" /id="U673" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.949050949050949" /psig="0.998001998001998" /xcortree=432 /SigmaFactorBS="catatgtaaattccagttcaaccgaaaacatgaagaaaatcc catcgggttTGTGCTATAGTTAAAACAGAgggggatggacatggcgaaatactccagc a" /listShort="ygzB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 894969..894972 /Source="Nicolas_upshift_promotors" /id="U674" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.736263736263736" /psig="0.996003996003996" /xcortree=95 /SigmaFactorBS="tttcttcatgttttcggttgaactggaatttacatATGGaga gttactgtgaaATTGTTTATAATAGTTCAATgtgtttagaaaaaaggaatttcgtttt a" /listShort="S303, ygxA, S304" /listLong="rrnD-16S" /label="promotor_-35" promotor_-10 894987..895006 /Source="Nicolas_upshift_promotors" /id="U674" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.736263736263736" /psig="0.996003996003996" /xcortree=95 /SigmaFactorBS="tttcttcatgttttcggttgaactggaatttacatATGGaga gttactgtgaaATTGTTTATAATAGTTCAATgtgtttagaaaaaaggaatttcgtttt a" /listShort="S303, ygxA, S304" /listLong="rrnD-16S" /label="promotor_-10" S_feature 894994..895096 /Source="Nicolas_S_feature" /locus_tag="new_945417_945519" /HighExp="BMM, Cold, LBGstat, C30, Oxctl, LBGexp, Paraq, G180, Lbexp, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="0.996, 0.0739" /TUlongSig="NA" /TUlongPSig="NA" /label="S303" upshifts 894994 /Source="Nicolas_upshifts" /id="U674" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.736263736263736" /psig="0.996003996003996" /xcortree=95 /SigmaFactorBS="tttcttcatgttttcggttgaactggaatttacatATGGaga gttactgtgaaATTGTTTATAATAGTTCAATgtgtttagaaaaaaggaatttcgtttt a" /listShort="S303, ygxA, S304" /listLong="rrnD-16S" /label="upshifts" CDS 895097..895981 /gene="ygxA" /locus_tag="BSU_08750" /old_locus_tag="BSU08750" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388755.1" /db_xref="EnsemblGenomes-Gn:BSU08750" /db_xref="EnsemblGenomes-Tr:CAB12703" /db_xref="InterPro:IPR029348" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10951" /db_xref="UniProtKB/Swiss-Prot:Q04385" /translation="MENLLRPIYQERASHPNTLAVIMIERRNKTSSLTDNFDAALLVI VKDADEPVFIKHYEFDHQTASLHVVTDSQIQEWILLGTNRRIIDWIVNGRVLFDRNEY VVELIDRLNTFPFAERKLKIGLEYGKLIRRYVEGKAFFEANQFLDAYNAVVHALHHLA RIEVIDRGFHPETTVWSQVRQMEPQVYKLYSELIESHESLEKRLELLFLANDFLIHSK AEIGSAHLFEVMKEKDIWQFGELLQHHDLKHFTQDLGVMLDYLTEKGLINVCQIETKG QAVYHRGYSFKKGVDSDS*" /label="ygxA CDS" gene 895097..895981 /gene="ygxA" /locus_tag="BSU_08750" /old_locus_tag="BSU08750" /label="ygxA gene" promotor_-35 895964..895971 /Source="Nicolas_upshift_promotors" /id="U675" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2619 /SigmaFactorBS="cgaggatattcttttaaaaaaggtGTTGACTCtgattcttga ccgTGTTATATTATTAAACGTCGctgatgcgcttctgagaaaacaagctcacagcggc g" /listShort="S304, rrnD-16S" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 895985..896004 /Source="Nicolas_upshift_promotors" /id="U675" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2619 /SigmaFactorBS="cgaggatattcttttaaaaaaggtGTTGACTCtgattcttga ccgTGTTATATTATTAAACGTCGctgatgcgcttctgagaaaacaagctcacagcggc g" /listShort="S304, rrnD-16S" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 896000..896272 /Source="Nicolas_S_feature" /locus_tag="new_946423_946695" /HighExp="LBGstat, Oxctl, C30, Paraq, GM 120, H2O2, HPh, G150, LPh, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.106881" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.996" /TUlongSig="Sig-" /TUlongPSig="0.0739" /label="S304" upshifts 896000 /Source="Nicolas_upshifts" /id="U675" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2619 /SigmaFactorBS="cgaggatattcttttaaaaaaggtGTTGACTCtgattcttga ccgTGTTATATTATTAAACGTCGctgatgcgcttctgagaaaacaagctcacagcggc g" /listShort="S304, rrnD-16S" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(896033) /Source="Nicolas_upshifts" /id="D440" /incds=0 /nref=1 /ntot=20 /MaxReadThrough="2.70619" /MaxDrop="3.85046" /score="4.43428373" /energy="-7.8" /TU="NA" /idTUdmin="U673" /TUdmin="-1474" /isTUend="FALSE" /label="downshifts" rRNA 896273..897827 /gene="rrnD-16S" /locus_tag="BSU_rRNA_22" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnD-16S rRNA" gene 896273..897827 /gene="rrnD-16S" /locus_tag="BSU_rRNA_22" /label="rrnD-16S gene" rRNA 897995..900922 /gene="rrnD-23S" /locus_tag="BSU_rRNA_17" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnD-23S rRNA" gene 897995..900922 /gene="rrnD-23S" /locus_tag="BSU_rRNA_17" /label="rrnD-23S gene" S_feature 900923..901008 /Source="Nicolas_S_feature" /locus_tag="new_951346_951431" /HighExp="G135, C30, Oxctl, Paraq, LBGstat, dia0, HiTm, Fru, G180, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S305" promotor_-35 900984..900991 /Source="Nicolas_upshift_promotors" /id="U676" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.852147852147852" /psig=1 /xcortree=2417 /SigmaFactorBS="ctagttttgagagaataagtttttcaaaaaaacaCTTGATTT tctcaagaatacaTAGTATAATGTTAAATGTCActgaaattgtctggtgatgatggcg a" /listShort="rrnD-5S, trnD-Asn, trnD-Ser, trnD-Glu, trnD-Val, trnD-Met, trnD-Asp, trnD-Phe, trnD-Thr, trnD-Tyr, trnD-Trp, trnD-His, trnD-Gln, trnD-Gly, trnD-Cys, trnD-Leu1, S306, S307, trnD-Leu2, ygzA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 901005..901024 /Source="Nicolas_upshift_promotors" /id="U676" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.852147852147852" /psig=1 /xcortree=2417 /SigmaFactorBS="ctagttttgagagaataagtttttcaaaaaaacaCTTGATTT tctcaagaatacaTAGTATAATGTTAAATGTCActgaaattgtctggtgatgatggcg a" /listShort="rrnD-5S, trnD-Asn, trnD-Ser, trnD-Glu, trnD-Val, trnD-Met, trnD-Asp, trnD-Phe, trnD-Thr, trnD-Tyr, trnD-Trp, trnD-His, trnD-Gln, trnD-Gly, trnD-Cys, trnD-Leu1, S306, S307, trnD-Leu2, ygzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 901010 /Source="Nicolas_upshifts" /id="U676" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.852147852147852" /psig=1 /xcortree=2417 /SigmaFactorBS="ctagttttgagagaataagtttttcaaaaaaacaCTTGATTT tctcaagaatacaTAGTATAATGTTAAATGTCActgaaattgtctggtgatgatggcg a" /listShort="rrnD-5S, trnD-Asn, trnD-Ser, trnD-Glu, trnD-Val, trnD-Met, trnD-Asp, trnD-Phe, trnD-Thr, trnD-Tyr, trnD-Trp, trnD-His, trnD-Gln, trnD-Gly, trnD-Cys, trnD-Leu1, S306, S307, trnD-Leu2, ygzA" /GFF_Attribute="listLong" /label="upshifts" rRNA 901034..901149 /gene="rrnD-5S" /locus_tag="BSU_rRNA_18" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnD-5S rRNA" gene 901034..901149 /gene="rrnD-5S" /locus_tag="BSU_rRNA_18" /label="rrnD-5S gene" tRNA 901159..901233 /gene="asnTA" /locus_tag="BSU_tRNA_29" /product="tRNA-Asn" /inference="profile:tRNAscan:1.23" /note="asparagine transfer RNA (GUU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="asnTA tRNA" gene 901159..901233 /gene="asnTA" /locus_tag="BSU_tRNA_29" /label="asnTA gene" tRNA 901239..901330 /gene="trnD-Ser" /locus_tag="BSU_tRNA_30" /product="tRNA-Ser" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ser(GGA); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-Ser tRNA" gene 901239..901330 /gene="trnD-Ser" /locus_tag="BSU_tRNA_30" /label="trnD-Ser gene" downshifts 901326 /Source="Nicolas_upshifts" /id="D441" /incds=0 /nref=2 /ntot=20 /MaxReadThrough="7.64297" /MaxDrop="4.37505" /score="-9.7424199" /energy="-11" /TU="U676" /idTUdmin="U677" /TUdmin="-1562" /isTUend="FALSE" /label="downshifts" tRNA 901365..901436 /gene="trnD-Glu" /locus_tag="BSU_tRNA_31" /product="tRNA-Glu" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Glu(UUC); Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-Glu tRNA" gene 901365..901436 /gene="trnD-Glu" /locus_tag="BSU_tRNA_31" /label="trnD-Glu gene" tRNA 901446..901521 /gene="trnD-Val" /locus_tag="BSU_tRNA_32" /product="tRNA-Val" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Val(UAC); Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-Val tRNA" gene 901446..901521 /gene="trnD-Val" /locus_tag="BSU_tRNA_32" /label="trnD-Val gene" tRNA 901531..901607 /gene="trnD-Met" /locus_tag="BSU_tRNA_33" /product="tRNA-Met" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Met(CAU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-Met tRNA" gene 901531..901607 /gene="trnD-Met" /locus_tag="BSU_tRNA_33" /label="trnD-Met gene" tRNA 901619..901695 /gene="trnD-Asp" /locus_tag="BSU_tRNA_34" /product="tRNA-Asp" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Asp(GUC); Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-Asp tRNA" gene 901619..901695 /gene="trnD-Asp" /locus_tag="BSU_tRNA_34" /label="trnD-Asp gene" tRNA 901708..901783 /gene="trnD-Phe" /locus_tag="BSU_tRNA_35" /product="tRNA-Phe" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Phe(GAA); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-Phe tRNA" gene 901708..901783 /gene="trnD-Phe" /locus_tag="BSU_tRNA_35" /label="trnD-Phe gene" tRNA 901789..901861 /gene="trnD-Thr" /locus_tag="BSU_tRNA_36" /product="tRNA-Thr" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Thr(UGU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-Thr tRNA" gene 901789..901861 /gene="trnD-Thr" /locus_tag="BSU_tRNA_36" /label="trnD-Thr gene" tRNA 901884..901968 /gene="trnD-Tyr" /locus_tag="BSU_tRNA_37" /product="tRNA-Tyr" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Tyr(GUA); Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-Tyr tRNA" gene 901884..901968 /gene="trnD-Tyr" /locus_tag="BSU_tRNA_37" /label="trnD-Tyr gene" tRNA 901974..902047 /gene="trnD-Trp" /locus_tag="BSU_tRNA_38" /product="tRNA-Trp" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Trp(CCA); Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-Trp tRNA" gene 901974..902047 /gene="trnD-Trp" /locus_tag="BSU_tRNA_38" /label="trnD-Trp gene" tRNA 902072..902147 /gene="trnD-His" /locus_tag="BSU_tRNA_39" /product="tRNA-His" /inference="profile:tRNAscan:1.23" /note="transfer RNA-His(GUG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-His tRNA" gene 902072..902147 /gene="trnD-His" /locus_tag="BSU_tRNA_39" /label="trnD-His gene" tRNA 902157..902228 /gene="trnD-Gln" /locus_tag="BSU_tRNA_40" /product="tRNA-Gln" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Gln(UUG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnD-Gln tRNA" gene 902157..902228 /gene="trnD-Gln" /locus_tag="BSU_tRNA_40" /label="trnD-Gln gene" tRNA 902278..902352 /gene="glyTB" /locus_tag="BSU_tRNA_41" /product="tRNA-Gly" /inference="profile:tRNAscan:1.23" /note="glycine transfer RNA (GCC); Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="glyTB tRNA" gene 902278..902352 /gene="glyTB" /locus_tag="BSU_tRNA_41" /label="glyTB gene" tRNA 902358..902428 /gene="cysTA" /locus_tag="BSU_tRNA_42" /product="tRNA-Cys" /inference="profile:tRNAscan:1.23" /note="cysteine tRNA (GCA); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="cysTA tRNA" gene 902358..902428 /gene="cysTA" /locus_tag="BSU_tRNA_42" /label="cysTA gene" tRNA 902436..902524 /gene="leuTA" /locus_tag="BSU_tRNA_43" /product="tRNA-Leu" /inference="profile:tRNAscan:1.23" /note="leucine RNA (UAA); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="leuTA tRNA" gene 902436..902524 /gene="leuTA" /locus_tag="BSU_tRNA_43" /label="leuTA gene" S_feature 902525..902601 /Source="Nicolas_S_feature" /locus_tag="new_952948_953024" /HighExp="Paraq, C30, Oxctl, G180, G135, Heat, BMM, LBGexp, dia15, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S306" downshifts 902558 /Source="Nicolas_upshifts" /id="D442" /incds=0 /nref=18 /ntot=231 /MaxReadThrough="5.36857" /MaxDrop="5.05259" /score="16.6649124" /energy="-8.9" /TU="U676" /idTUdmin="U677" /TUdmin="-330" /isTUend="FALSE" /label="downshifts" S_feature 902603..902771 /Source="Nicolas_S_feature" /locus_tag="new_953026_953194" /HighExp="Heat, Paraq, BMM, Oxctl, H2O2, Cold, G180, Pyr, C30, Glu" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S307" promotor_-35 902728..902735 /Source="Nicolas_upshift_promotors" /id="U677" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.927072927072927" /psig="0.998001998001998" /xcortree=687 /SigmaFactorBS="acttttttgaaatacGTTGACACtttatgagatccaTGATAT ATTTATATTCGTCGgttagatacgacgtaaaacttgccggtgtggcggaattggcaga c" /listShort="trnD-Leu2" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 902734 /Source="Nicolas_upshifts" /id="D443" /incds=0 /nref=1 /ntot=14 /MaxReadThrough="3.84674" /MaxDrop="3.439" /score="35.1424037" /energy="-12.4" /TU="U676" /idTUdmin="U677" /TUdmin="-154" /isTUend="FALSE" /label="downshifts" promotor_-10 902749..902768 /Source="Nicolas_upshift_promotors" /id="U677" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.927072927072927" /psig="0.998001998001998" /xcortree=687 /SigmaFactorBS="acttttttgaaatacGTTGACACtttatgagatccaTGATAT ATTTATATTCGTCGgttagatacgacgtaaaacttgccggtgtggcggaattggcaga c" /listShort="trnD-Leu2" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 902773 /Source="Nicolas_upshifts" /id="U677" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.927072927072927" /psig="0.998001998001998" /xcortree=687 /SigmaFactorBS="acttttttgaaatacGTTGACACtttatgagatccaTGATAT ATTTATATTCGTCGgttagatacgacgtaaaacttgccggtgtggcggaattggcaga c" /listShort="trnD-Leu2" /GFF_Attribute="listLong" /label="upshifts" tRNA 902790..902871 /gene="leuTB" /locus_tag="BSU_tRNA_44" /product="tRNA-Leu" /inference="profile:tRNAscan:1.23" /note="leucine tRNA(CAA); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="leuTB tRNA" gene 902790..902871 /gene="leuTB" /locus_tag="BSU_tRNA_44" /label="leuTB gene" promotor_-10 complement(902807..902824) /Source="Nicolas_upshift_promotors" /id="U678" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.925074925074925" /psig="0.012987012987013" /xcortree=395 /SigmaFactorBS="accggtggtcggggtcgaacCGACACtccagaaggaacacga ttttGAGTCGTGCGCGTCTGCCaattccgccacaccggcaagttttacgtcgtatcta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(902810) /Source="Nicolas_upshifts" /id="U678" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.925074925074925" /psig="0.012987012987013" /xcortree=395 /SigmaFactorBS="accggtggtcggggtcgaacCGACACtccagaaggaacacga ttttGAGTCGTGCGCGTCTGCCaattccgccacaccggcaagttttacgtcgtatcta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(902845..902850) /Source="Nicolas_upshift_promotors" /id="U678" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.925074925074925" /psig="0.012987012987013" /xcortree=395 /SigmaFactorBS="accggtggtcggggtcgaacCGACACtccagaaggaacacga ttttGAGTCGTGCGCGTCTGCCaattccgccacaccggcaagttttacgtcgtatcta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(902880) /Source="Nicolas_upshifts" /id="D444" /incds=0 /nref=5 /ntot=151 /MaxReadThrough="1.64364" /MaxDrop="6.28675" /score="7.71223568" /energy="-12.4" /TU="NA" /idTUdmin="U679" /TUdmin=18 /isTUend="TRUE" /label="downshifts" CDS complement(902950..903726) /gene="spo0M" /locus_tag="BSU_08760" /old_locus_tag="BSU08760" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9795118, 22142536, 26625291, 28234965" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9795118, 22142536, 26625291, 28234965; Product type r: regulator" /codon_start=1 /transl_table=11 /product="protein involved in the control of the cell cycle as a function of the environment" /protein_id="NP_388756.2" /db_xref="EnsemblGenomes-Gn:BSU08760" /db_xref="EnsemblGenomes-Tr:CAB12704" /db_xref="GOA:P71088" /db_xref="InterPro:IPR009776" /db_xref="InterPro:IPR014756" /db_xref="PDB:5CL2" /db_xref="SubtiList:BG12229" /db_xref="UniProtKB/Swiss-Prot:P71088" /translation="MSFFKKLAASAGIGAAKVDTILEKDAYFPGEEVQGTVHVKGGKI AQDIRYIDLQLSTRYVIVKDDEEHRKYATIHSFRVTGSFTIQPGEEHQFPFTFTLPLD TPITVGKVEVAVVTDLDIQGGIDKSDHDRIFVEAHPWIENVLEAIENLGFRLNEADCE QAPYFQRRLPFVQEFEFVPTSGYYRQMLDELELIFLLDEDGLEIIFEVDRRARGLRGW LEEMYNDGEQLVRVRFSQSELEDTEELEEVLEEILDQYAE*" /label="spo0M CDS" gene complement(902950..903726) /gene="spo0M" /locus_tag="BSU_08760" /old_locus_tag="BSU08760" /label="spo0M gene" downshifts complement(902964) /Source="Nicolas_upshifts" /id="D445" /incds=0 /nref=9 /ntot=131 /MaxReadThrough="6.06864" /MaxDrop="6.58787" /score="6.75662782" /energy="-7" /TU="U679" /idTUdmin="U679" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(903753..903768) /Source="Nicolas_upshift_promotors" /id="U679" /multdbtbs="SigH" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1665 /SigmaFactorBS="tgtccctaggccgagacgaataataggaaaaaagtatgaatc aaaCGAATCTTTTttcctccttcttACGTATATCTGTTGAGaaaaaagaaaaagggga a" /listShort="spo0M" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(903775) /Source="Nicolas_upshifts" /id="U679" /multdbtbs="SigH" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1665 /SigmaFactorBS="tgtccctaggccgagacgaataataggaaaaaagtatgaatc aaaCGAATCTTTTttcctccttcttACGTATATCTGTTGAGaaaaaagaaaaagggga a" /listShort="spo0M" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(903781..903790) /Source="Nicolas_upshift_promotors" /id="U679" /multdbtbs="SigH" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1665 /SigmaFactorBS="tgtccctaggccgagacgaataataggaaaaaagtatgaatc aaaCGAATCTTTTttcctccttcttACGTATATCTGTTGAGaaaaaagaaaaagggga a" /listShort="spo0M" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 903810..903816 /Source="Nicolas_upshift_promotors" /id="U680" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=873 /SigmaFactorBS="ggaggaaaaaagattcgtttgattcatacttttttcCTATTA TtcgtctcggcctagGGACAGACTAAGaataatattgaaaataaaggagtcgatggaa g" /listShort="ygzA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 903831..903842 /Source="Nicolas_upshift_promotors" /id="U680" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=873 /SigmaFactorBS="ggaggaaaaaagattcgtttgattcatacttttttcCTATTA TtcgtctcggcctagGGACAGACTAAGaataatattgaaaataaaggagtcgatggaa g" /listShort="ygzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 903834 /Source="Nicolas_upshifts" /id="U680" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=873 /SigmaFactorBS="ggaggaaaaaagattcgtttgattcatacttttttcCTATTA TtcgtctcggcctagGGACAGACTAAGaataatattgaaaataaaggagtcgatggaa g" /listShort="ygzA" /GFF_Attribute="listLong" /label="upshifts" CDS 903868..904071 /gene="ygzA" /locus_tag="BSU_08770" /old_locus_tag="BSU08770" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388757.2" /db_xref="EnsemblGenomes-Gn:BSU08770" /db_xref="EnsemblGenomes-Tr:CAB12705" /db_xref="SubtiList:BG12981" /db_xref="UniProtKB/Swiss-Prot:O31586" /translation="MEVNKESLVADELHRMFLAGELQITVEEDINNISERLRNGDLSL DRLSGEDVFIKETVNEALRRVEQ*" /label="ygzA CDS" gene 903868..904071 /gene="ygzA" /locus_tag="BSU_08770" /old_locus_tag="BSU08770" /label="ygzA gene" downshifts 904054 /Source="Nicolas_upshifts" /id="D446" /incds=0 /nref=22 /ntot=97 /MaxReadThrough="1.47004" /MaxDrop="5.47861" /score="15.4081475" /energy="-18.2" /TU="NA" /idTUdmin="U676" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(904130) /Source="Nicolas_upshifts" /id="D447" /incds=0 /nref=10 /ntot=35 /MaxReadThrough="1.31339" /MaxDrop="4.8918" /score="26.0684119" /energy="-18.2" /TU="NA" /idTUdmin="U681" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(904156..904428) /gene="ygzC" /locus_tag="BSU_08779" /old_locus_tag="BSU08779" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="YP_003097696.1" /db_xref="EnsemblGenomes-Gn:BSU08779" /db_xref="EnsemblGenomes-Tr:CAX52583" /db_xref="GOA:C0H3X8" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR012851" /db_xref="UniProtKB/Swiss-Prot:C0H3X8" /translation="MYRSKKQSQILSYQELLKKQRRWFPIEQSLCPKDILDLLTTIKT SINKYTVATTATENPHIRRALHDQLDTAVYLHDELSDLLLEKGWLG*" /label="ygzC CDS" gene complement(904156..904428) /gene="ygzC" /locus_tag="BSU_08779" /old_locus_tag="BSU08779" /label="ygzC gene" promotor_-10 complement(904387..904405) /Source="Nicolas_upshift_promotors" /id="U681" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.94005994005994" /psig="0.94005994005994" /xcortree=1185 /SigmaFactorBS="caaaatttgttgcttattatagcatttTGTATAgaagcaaga aacaaagTCAAATACTTTCTTATCAGgagctgctaaaaaaacaaaggaggtggtttcc c" /listShort="ygzC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(904394) /Source="Nicolas_upshifts" /id="U681" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.94005994005994" /psig="0.94005994005994" /xcortree=1185 /SigmaFactorBS="caaaatttgttgcttattatagcatttTGTATAgaagcaaga aacaaagTCAAATACTTTCTTATCAGgagctgctaaaaaaacaaaggaggtggtttcc c" /listShort="ygzC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 904409..904416 /Source="Nicolas_upshift_promotors" /id="U682" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.478521478521479" /psig=1 /xcortree=2885 /SigmaFactorBS="ttagcagctcctgataagaaagtatttgacttTGTTTCTTgc ttctatacaaAATGCTATAATAAGCAACAAattttgttggggggtgtgatgatgaagc a" /listShort="ygaJ" /listLong="NA, thiC, S308" /label="promotor_-35" promotor_-35 complement(904422..904427) /Source="Nicolas_upshift_promotors" /id="U681" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.94005994005994" /psig="0.94005994005994" /xcortree=1185 /SigmaFactorBS="caaaatttgttgcttattatagcatttTGTATAgaagcaaga aacaaagTCAAATACTTTCTTATCAGgagctgctaaaaaaacaaaggaggtggtttcc c" /listShort="ygzC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 904429..904448 /Source="Nicolas_upshift_promotors" /id="U682" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.478521478521479" /psig=1 /xcortree=2885 /SigmaFactorBS="ttagcagctcctgataagaaagtatttgacttTGTTTCTTgc ttctatacaaAATGCTATAATAAGCAACAAattttgttggggggtgtgatgatgaagc a" /listShort="ygaJ" /listLong="NA, thiC, S308" /label="promotor_-10" upshifts 904437 /Source="Nicolas_upshifts" /id="U682" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.478521478521479" /psig=1 /xcortree=2885 /SigmaFactorBS="ttagcagctcctgataagaaagtatttgacttTGTTTCTTgc ttctatacaaAATGCTATAATAAGCAACAAattttgttggggggtgtgatgatgaagc a" /listShort="ygaJ" /listLong="NA, thiC, S308" /label="upshifts" CDS 904470..905162 /gene="ygaJ" /locus_tag="BSU_08780" /old_locus_tag="BSU08780" /EC_number="3.4.21.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative peptidase" /protein_id="NP_388758.2" /db_xref="EnsemblGenomes-Gn:BSU08780" /db_xref="EnsemblGenomes-Tr:CAB12706" /db_xref="GOA:P71089" /db_xref="InterPro:IPR005320" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG12230" /db_xref="UniProtKB/Swiss-Prot:P71089" /translation="MKQIIAMGGGGFSMEPDNLSLDQYILNQSKREQPRICFLPTASG DSQNYIQRFYHAFQTLDCVPSHLSLFKPPSSDLVSFVMEMDVIYVGGGNTRNLLVLWK EWGLDHILREAWKNGVVVAGISAGAICWFEEGVTDSAGPLTSLKSLGFLQGSFCPHYD GEKDRRPAYHQLISNKFLCSGYAADDGAALHFINDQLFQTVSSRSGAKAYRVMMAEHE IAEIPLPVKYLG*" /label="ygaJ CDS" gene 904470..905162 /gene="ygaJ" /locus_tag="BSU_08780" /old_locus_tag="BSU08780" /label="ygaJ gene" promotor_-35 905191..905195 /Source="Nicolas_upshift_promotors" /id="U684" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.616383616383616" /psig="0.946053946053946" /xcortree=2883 /SigmaFactorBS="tctatattcctcTTTTTttcagattgatttTATGATAAGATG AGTGCGAAatcaatagttactgggggtgcccgctttcgggctgagagagaaggcaagc t" /listShort="NA, thiC, S308" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(905194..905213) /Source="Nicolas_upshift_promotors" /id="U683" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.863136863136863" /psig="0.997002997002997" /xcortree=2976 /SigmaFactorBS="tctcagcccgaaagcgggcacccccagtaacTATTGATTtcg cactcatcttaTCATAAAATCAATCTGAAAAaaagaggaatatagataatattcagcc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(905206) /Source="Nicolas_upshifts" /id="U683" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.863136863136863" /psig="0.997002997002997" /xcortree=2976 /SigmaFactorBS="tctcagcccgaaagcgggcacccccagtaacTATTGATTtcg cactcatcttaTCATAAAATCAATCTGAAAAaaagaggaatatagataatattcagcc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 905209..905228 /Source="Nicolas_upshift_promotors" /id="U684" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.616383616383616" /psig="0.946053946053946" /xcortree=2883 /SigmaFactorBS="tctatattcctcTTTTTttcagattgatttTATGATAAGATG AGTGCGAAatcaatagttactgggggtgcccgctttcgggctgagagagaaggcaagc t" /listShort="NA, thiC, S308" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(905228..905235) /Source="Nicolas_upshift_promotors" /id="U683" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.863136863136863" /psig="0.997002997002997" /xcortree=2976 /SigmaFactorBS="tctcagcccgaaagcgggcacccccagtaacTATTGATTtcg cactcatcttaTCATAAAATCAATCTGAAAAaaagaggaatatagataatattcagcc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" misc_RNA 905232..905339 /gene="tswD" /locus_tag="BSU_misc_RNA_11" /product="thiamine pyrophosphate riboswitch" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11470904, 12410317, 15862294, 16728979, 16962976, 17307816, 18179415, 18776013; Product type n: RNA" /function="16.3: Control" /label="tswD RNA" gene 905232..905339 /gene="tswD" /locus_tag="BSU_misc_RNA_11" /label="tswD gene" upshifts 905239 /Source="Nicolas_upshifts" /id="U684" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.616383616383616" /psig="0.946053946053946" /xcortree=2883 /SigmaFactorBS="tctatattcctcTTTTTttcagattgatttTATGATAAGATG AGTGCGAAatcaatagttactgggggtgcccgctttcgggctgagagagaaggcaagc t" /listShort="NA, thiC, S308" /GFF_Attribute="listLong" /label="upshifts" downshifts 905370 /Source="Nicolas_upshifts" /id="D448" /incds=0 /nref=13 /ntot=48 /MaxReadThrough="8.09735" /MaxDrop="5.74046" /score="17.5556194" /energy="-12.4" /TU="U684" /idTUdmin="U682" /TUdmin=152 /isTUend="FALSE" /label="downshifts" CDS 905472..907244 /gene="thiC" /locus_tag="BSU_08790" /old_locus_tag="BSU08790" /EC_number="4.1.99.17" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8432721, 9370266, 10382260, 16291685, 26443755" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8432721, 9370266, 10382260, 16291685, 26443755; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphomethylpyrimidine synthase" /protein_id="NP_388759.2" /db_xref="EnsemblGenomes-Gn:BSU08790" /db_xref="EnsemblGenomes-Tr:CAB12707" /db_xref="GOA:P45740" /db_xref="InterPro:IPR002817" /db_xref="InterPro:IPR025747" /db_xref="SubtiList:BG11246" /db_xref="UniProtKB/Swiss-Prot:P45740" /translation="MQNNSVQQANISIMSSFSGSKKVYVEGSSSDIQVPMREIALSPT TGSFGEEENAPVRVYDTSGPYTDPEVTINIQEGLKPLRQKWITERGDVEEYEGRAIKP EDNGYKKAKPNVSYPGLKRKPLRAKAGQNVTQMHYAKKGIITPEMEFIAIREHVSPEF VRDEVASGRAIIPSNINHPESEPMIIGRNFHVKINANIGNSAVTSSIEEEVEKMTWAI RWGADTMMDLSTGKDIHTTREWIIRNCPVPVGTVPIYQALEKVNGVAEDLTWEIYRDT LIEQAEQGVDYFTIHAGVLLRYVPLTAKRTTGIVSRGGAIMAQWCLAHHQESFLYTHF EEICEIMKMYDIAFSLGDGLRPGSIADANDEAQFAELETLGELTQIAWKHDVQVMIEG PGHVPMHKIKENVDKQMDICKEAPFYTLGPLTTDIAPGYDHITSAIGAAMIGWYGTAM LCYVTPKEHLGLPNRDDVREGVITYKIAAHAADLAKGHPGAQIRDDALSKARFEFRWR DQFNLSLDPERALEYHDETLPAEGAKTAHFCSMCGPKFCSMRISQDIRDYAKKNDLSE AEAINKGLKEKAKEFVDTGSNLYQ*" /label="thiC CDS" gene 905472..907244 /gene="thiC" /locus_tag="BSU_08790" /old_locus_tag="BSU08790" /label="thiC gene" downshifts 907220 /Source="Nicolas_upshifts" /id="D449" /incds=0 /nref=166 /ntot=257 /MaxReadThrough="5.77069" /MaxDrop="5.3684" /score="25.2366359" /energy="-15.3" /TU="U684" /idTUdmin="U684" /TUdmin="-946" /isTUend="FALSE" /label="downshifts" S_feature 907265..908190 /Source="Nicolas_S_feature" /locus_tag="new_957688_958613" /HighExp="HiOs, GM-0.1, GM 45, GM 60, GM-0.2, BMM, MG 90, T-5.40H, MG 15, MG 25" /AntisenseName="ygaK" /AntisenseCor="-9.7288827054566707E-2" /AntisenseRegPval="-1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.946" /TUlongSig="SigA" /TUlongPSig=1 /label="S308" CDS complement(907282..908637) /gene="ygaK" /locus_tag="BSU_08800" /old_locus_tag="BSU08800" /EC_number="1.21.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8972604; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative FAD-dependent oxido-reductase" /protein_id="NP_388760.2" /db_xref="EnsemblGenomes-Gn:BSU08800" /db_xref="EnsemblGenomes-Tr:CAB12708" /db_xref="GOA:Q796Y5" /db_xref="InterPro:IPR006094" /db_xref="InterPro:IPR012951" /db_xref="InterPro:IPR016166" /db_xref="InterPro:IPR016167" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR036318" /db_xref="SubtiList:BG12231" /db_xref="UniProtKB/Swiss-Prot:Q796Y5" /translation="MEKTKLTGRIVTRDDPDYNEARTNINLSLERYPDIIVFCQNKQD ALNALKWARENRVPFRIRGGRHSYENFSLLNNGLVIDLSEMKKITVNQDKKLAYIEAG AELGEVYRTLWQYGLTLPAGTIANVGLTGLTLGGGIGLLTRAAGLTCDSLVQLEMIVA DEKEGADLITVSCSNHPDLFWASQGGGGGNFGIVTSMTFKAVPISQVSIFSITWGWDD FEEVYNTWQNWAPYTDDRLTSSIEFWPKEVNRIEALGQFVGPKTELKKLLKPLLKAGS PTSGMVKTTPFIEAVTFFNSPGGNQPQKMKRSGSFIEKPLSERAISTIKHFLEHAPNQ NASVWQQALGGAAGRVAPDQTAFYYRDAIIAQEYLTNWTSPGEKRQNVRWIEGLRTSL SKETMGDYVNWPDIEIRNWPRTYYGENVERLRRVKTTYDPENVFRFEQSIPPLRRSLF F*" /label="ygaK CDS" gene complement(907282..908637) /gene="ygaK" /locus_tag="BSU_08800" /old_locus_tag="BSU08800" /label="ygaK gene" promotor_-10 complement(908665..908684) /Source="Nicolas_upshift_promotors" /id="U685" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1414 /SigmaFactorBS="tgttgacactgtatcagattgcatccccgctttttCCTTATA CACtcttttcccctgaCGCATAAGCTAGAGAAACTAgaatacgagagaaagagatgtg g" /listShort="ygaK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(908682) /Source="Nicolas_upshifts" /id="U685" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1414 /SigmaFactorBS="tgttgacactgtatcagattgcatccccgctttttCCTTATA CACtcttttcccctgaCGCATAAGCTAGAGAAACTAgaatacgagagaaagagatgtg g" /listShort="ygaK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(908698..908707) /Source="Nicolas_upshift_promotors" /id="U685" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1414 /SigmaFactorBS="tgttgacactgtatcagattgcatccccgctttttCCTTATA CACtcttttcccctgaCGCATAAGCTAGAGAAACTAgaatacgagagaaagagatgtg g" /listShort="ygaK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 908755..908761 /Source="Nicolas_upshift_promotors" /id="U686" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.48951048951049" /psig="0.954045954045954" /xcortree=1737 /SigmaFactorBS="cctcaaaaaatAGTTGACaggtcggtattgtaTGAATTAACA TGGTCAGTACaaatttttcaaatttatcgcgctgatcggaacaccgaaggctcttatc g" /listShort="senS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 908776..908795 /Source="Nicolas_upshift_promotors" /id="U686" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.48951048951049" /psig="0.954045954045954" /xcortree=1737 /SigmaFactorBS="cctcaaaaaatAGTTGACaggtcggtattgtaTGAATTAACA TGGTCAGTACaaatttttcaaatttatcgcgctgatcggaacaccgaaggctcttatc g" /listShort="senS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 908804 /Source="Nicolas_upshifts" /id="U686" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.48951048951049" /psig="0.954045954045954" /xcortree=1737 /SigmaFactorBS="cctcaaaaaatAGTTGACaggtcggtattgtaTGAATTAACA TGGTCAGTACaaatttttcaaatttatcgcgctgatcggaacaccgaaggctcttatc g" /listShort="senS" /GFF_Attribute="listLong" /label="upshifts" CDS 908888..909085 /gene="senS" /locus_tag="BSU_08810" /old_locus_tag="BSU08810" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1479343, 2108127, 8323536, 16321961" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1479343, 2108127, 8323536, 16321961; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (repressor of ScoC)" /protein_id="NP_388761.2" /db_xref="EnsemblGenomes-Gn:BSU08810" /db_xref="EnsemblGenomes-Tr:CAB12709" /db_xref="GOA:P21344" /db_xref="InterPro:IPR025004" /db_xref="SubtiList:BG10747" /db_xref="UniProtKB/Swiss-Prot:P21344" /translation="MGVKKEKGRKRFRKRKTYGNQILPLELLIEKNKREIINSAELME EIYMKIDEKHTQCVTKYKKTR*" /label="senS CDS" gene 908888..909085 /gene="senS" /locus_tag="BSU_08810" /old_locus_tag="BSU08810" /label="senS gene" CDS complement(909112..910563) /gene="katA" /locus_tag="BSU_08820" /old_locus_tag="BSU08820" /EC_number="1.11.1.6" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12029044, 12486061, 16535198, 22194458, 27935957" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12029044, 12486061, 16535198, 22194458, 27935957; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="vegetative catalase 1" /protein_id="NP_388762.2" /db_xref="EnsemblGenomes-Gn:BSU08820" /db_xref="EnsemblGenomes-Tr:CAB12710" /db_xref="GOA:P26901" /db_xref="InterPro:IPR002226" /db_xref="InterPro:IPR010582" /db_xref="InterPro:IPR011614" /db_xref="InterPro:IPR018028" /db_xref="InterPro:IPR020835" /db_xref="InterPro:IPR024708" /db_xref="InterPro:IPR024711" /db_xref="InterPro:IPR037060" /db_xref="SubtiList:BG10849" /db_xref="UniProtKB/Swiss-Prot:P26901" /translation="MSSNKLTTSWGAPVGDNQNSMTAGSRGPTLIQDVHLLEKLAHFN RERVPERVVHAKGAGAHGYFEVTNDVTKYTKAAFLSEVGKRTPLFIRFSTVAGELGSA DTVRDPRGFAVKFYTEEGNYDIVGNNTPVFFIRDAIKFPDFIHTQKRDPKTHLKNPTA VWDFWSLSPESLHQVTILMSDRGIPATLRHMHGFGSHTFKWTNAEGEGVWIKYHFKTE QGVKNLDVNTAAKIAGENPDYHTEDLFNAIENGDYPAWKLYVQIMPLEDANTYRFDPF DVTKVWSQKDYPLIEVGRMVLDRNPENYFAEVEQATFSPGTLVPGIDVSPDKMLQGRL FAYHDAHRYRVGANHQALPINRARNKVNNYQRDGQMRFDDNGGGSVYYEPNSFGGPKE SPEDKQAAYPVQGIADSVSYDHYDHYTQAGDLYRLMSEDERTRLVENIVNAMKPVEKE EIKLRQIEHFYKADPEYGKRVAEGLGLPIKKDS*" /label="katA CDS" gene complement(909112..910563) /gene="katA" /locus_tag="BSU_08820" /old_locus_tag="BSU08820" /label="katA gene" downshifts complement(909122) /Source="Nicolas_upshifts" /id="D450" /incds=0 /nref=221 /ntot=261 /MaxReadThrough="1.32399" /MaxDrop="8.8938" /score="25.1548262" /energy="-8.3" /TU="NA" /idTUdmin="U688" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 910540..910546 /Source="Nicolas_upshift_promotors" /id="U687" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.382617382617383" /psig="0.528471528471528" /xcortree=1222 /SigmaFactorBS="tgagttttgattatctccaaccggagcgccccagctAGTTGT CagtttatttgaactCATGTTATCACCTCTTGGAAtttataagaacataatatcatct c" /listShort="S309, ssuB, ssuA, ssuC, ssuD, ygaN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 910561..910580 /Source="Nicolas_upshift_promotors" /id="U687" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.382617382617383" /psig="0.528471528471528" /xcortree=1222 /SigmaFactorBS="tgagttttgattatctccaaccggagcgccccagctAGTTGT CagtttatttgaactCATGTTATCACCTCTTGGAAtttataagaacataatatcatct c" /listShort="S309, ssuB, ssuA, ssuC, ssuD, ygaN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 910564 /Source="Nicolas_upshifts" /id="U687" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.382617382617383" /psig="0.528471528471528" /xcortree=1222 /SigmaFactorBS="tgagttttgattatctccaaccggagcgccccagctAGTTGT CagtttatttgaactCATGTTATCACCTCTTGGAAtttataagaacataatatcatct c" /listShort="S309, ssuB, ssuA, ssuC, ssuD, ygaN" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(910581..910600) /Source="Nicolas_upshift_promotors" /id="U688" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=1533 /SigmaFactorBS="attaatagagataactattttataataattataaaataaTAT TGACTttttacttagagaTGATATTATGTTCTTATAAAttccaagaggtgataacatg a" /listShort="katA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 910586..910915 /Source="Nicolas_S_feature" /locus_tag="new_961009_961338" /HighExp="S8, C30, S7, S6, BT, C90, B36, S4, S5, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.528" /TUlongSig="NA" /TUlongPSig="NA" /label="S309" upshifts complement(910600) /Source="Nicolas_upshifts" /id="U688" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=1533 /SigmaFactorBS="attaatagagataactattttataataattataaaataaTAT TGACTttttacttagagaTGATATTATGTTCTTATAAAttccaagaggtgataacatg a" /listShort="katA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(910614..910621) /Source="Nicolas_upshift_promotors" /id="U688" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=1533 /SigmaFactorBS="attaatagagataactattttataataattataaaataaTAT TGACTttttacttagagaTGATATTATGTTCTTATAAAttccaagaggtgataacatg a" /listShort="katA" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(910659..910677) /Source="Nicolas_upshift_promotors" /id="U689" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.351648351648352" /psig="0.602397602397602" /xcortree=647 /SigmaFactorBS="gaaaaattatttctccaaaaattattaagtgtcataaaaagc tgttacaacaaggtttttcaacaatTTCGATACTATATATCGATtaatagagataact a" /listShort="katA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(910684) /Source="Nicolas_upshifts" /id="U689" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.351648351648352" /psig="0.602397602397602" /xcortree=647 /SigmaFactorBS="gaaaaattatttctccaaaaattattaagtgtcataaaaagc tgttacaacaaggtttttcaacaatTTCGATACTATATATCGATtaatagagataact a" /listShort="katA" /GFF_Attribute="listLong" /label="upshifts" downshifts 910872 /Source="Nicolas_upshifts" /id="D451" /incds=0 /nref=9 /ntot=21 /MaxReadThrough="5.89897" /MaxDrop="4.66837" /score="39.0049465" /energy="-19.7" /TU="U687" /idTUdmin="U686" /TUdmin=1936 /isTUend="FALSE" /label="downshifts" CDS 910971..911738 /gene="ssuB" /locus_tag="BSU_08830" /old_locus_tag="BSU08830" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9782504, 11390694, 16513748, 16885442; Product type t: transporter" /codon_start=1 /transl_table=11 /product="aliphatic sulfonate ABC transporter (ATP-bindingprotein)" /protein_id="NP_388763.3" /db_xref="EnsemblGenomes-Gn:BSU08830" /db_xref="EnsemblGenomes-Tr:CAB12711" /db_xref="GOA:P97027" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR017875" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12232" /db_xref="UniProtKB/Swiss-Prot:P97027" /translation="MAVTISIKEKAFVQEGRKNTVLENIELSIAPGEFLTLIGPSGCG KSTLLKIIAGLDSEYDGSVEINGRSVTAPGIQQGFIFQEHRLFPWLTVEQNIAADLNL KDPKVKQKVDELIEIVRLKGSEKAYPRELSGGMSQRVAIARALLREPEVLLLDEPFGA LDAFTRKHLQDVLLDIWRKKKTTMILVTHDIDESVYLGNELAILKAKPGKIHKLMPIH LAYPRNRTTPDFQAIRQRVLSEFEKTEDLEYAEGSGI*" /label="ssuB CDS" gene 910971..911738 /gene="ssuB" /locus_tag="BSU_08830" /old_locus_tag="BSU08830" /label="ssuB gene" CDS 911756..912754 /gene="ssuA" /locus_tag="BSU_08840" /old_locus_tag="BSU08840" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9782504, 11390694, 16513748, 16885442; Product type f: factor" /codon_start=1 /transl_table=11 /product="aliphatic sulfonate ABC transporter (binding lipoprotein)" /protein_id="NP_388764.1" /db_xref="EnsemblGenomes-Gn:BSU08840" /db_xref="EnsemblGenomes-Tr:CAB12712" /db_xref="GOA:P40400" /db_xref="InterPro:IPR001638" /db_xref="InterPro:IPR010067" /db_xref="InterPro:IPR015168" /db_xref="SubtiList:BG10656" /db_xref="UniProtKB/Swiss-Prot:P40400" /translation="MKKGLIVLVAVIFLLAGCGANGASGDHKQLKEIRIGIQQSLSPL LIAKEKGWFEDAFEKEGIKVKWVEFQSGPPQFEGLAADKLDFSQVGNSPVIAGQAAGI DFKEIGLSQDGLKANGILVNQNSGIQDVKGLKGKKIAVAKGSSGFDFLYKALDQVGLS ANDVTIIQLQPDEAASAFENGSVDAWSIWEPYLSLETMKHGAKILVNGESTDLYSPGF TLVRTKFSEEHPDEVVRFLKVFNKAVVWQKEHLDEAADLYSDIKDLDKKVVENVLKNT EPLNEIISDDIVKAQQETADFQFRTKAIDKKIDVKDVVDNTFIKKALEEHSSGGDQ*" /label="ssuA CDS" gene 911756..912754 /gene="ssuA" /locus_tag="BSU_08840" /old_locus_tag="BSU08840" /label="ssuA gene" CDS 912751..913581 /gene="ssuC" /locus_tag="BSU_08850" /old_locus_tag="BSU08850" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11390694, 15849754, 16513748, 16850406, 16885442, 9782504" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11390694, 15849754, 16513748, 16850406, 16885442, 9782504; Product type t : transporter" /codon_start=1 /transl_table=11 /product="aliphatic sulfonate ABC transporter (permease)" /protein_id="NP_388765.1" /db_xref="EnsemblGenomes-Gn:BSU08850" /db_xref="EnsemblGenomes-Tr:CAB12713" /db_xref="GOA:P40401" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG10657" /db_xref="UniProtKB/Swiss-Prot:P40401" /translation="MMKAEAAGSLPKTNAEAVRKKPGRKRYGWMKGLLLPAVIIAIWQ VIGGLGVVSATVLPTPVTIVLTFKELILSGELFGHLQISIYRAALGFLLGAGLGLMIG ILAGFSKRTELYLDPSLQMLRTVPHLAVTPLFILWFGFDEVSKILLIALGAFFPVYIN TFNGIRGVDAKLFEVARVLEFKWHQQISKVILPAALPNILLGIRLSLGIAWLGLVVAE LMGSSSGVGYMIMDARQFSQTNKVFAGIIIFAVVGKLTDSFVRLLERKLLKWRNSYEG *" /label="ssuC CDS" gene 912751..913581 /gene="ssuC" /locus_tag="BSU_08850" /old_locus_tag="BSU08850" /label="ssuC gene" CDS 913604..914734 /gene="ssuD" /locus_tag="BSU_08860" /old_locus_tag="BSU08860" /EC_number="1.14.14.5" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9782504, 11390694, 16513748, 16885442" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9782504, 11390694, 16513748, 16885442; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="FMNH2-dependent aliphatic sulfonate monooxygenase" /protein_id="NP_388766.2" /db_xref="EnsemblGenomes-Gn:BSU08860" /db_xref="EnsemblGenomes-Tr:CAB12714" /db_xref="GOA:P40402" /db_xref="InterPro:IPR011251" /db_xref="InterPro:IPR019911" /db_xref="InterPro:IPR036661" /db_xref="SubtiList:BG10658" /db_xref="UniProtKB/Swiss-Prot:P40402" /translation="MEILWFIPTHGDARYLGSESDGRTADHLYFKQVAQAADRLGYTG VLLPTGRSCEDPWLTASALAGETKDLKFLVAVRPGLMQPSLAARMTSTLDRISDGRLL INVVAGGDPYELAGDGLFISHDERYEATDEFLTVWRRLLQGETVSYEGKHIKVENSNL LFPPQQEPHPPIYFGGSSQAGIEAAAKHTDVYLTWGEPPEQVKEKIERVKKQAAKEGR SVRFGIRLHVIARETEQEAWEAAERLISHLDDDTIAKAQAALSRYDSSGQQRMAVLHQ GDRTKLEISPNLWAGIGLVRGGAGTALVGDPQTIADRIAEYQALGIESFIFSGYPHLE EAYYFAELVFPLLPFENDRTRKLQNKRGEAVGNTYFVKEKNA*" /label="ssuD CDS" gene 913604..914734 /gene="ssuD" /locus_tag="BSU_08860" /old_locus_tag="BSU08860" /label="ssuD gene" misc_feature 914761..914780 /Source="Nicolas_upshift_promotors" /id="U690" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig="0.994005994005994" /xcortree=1467 /SigmaFactorBS="ttattttgtcaaagagaaaaatgcatgagtttaactaaaata cagccccccgaaCATGGTATGATATTCAAAAAaagggggctttttttctgaaaacatt g" /listShort="ygaN, S310" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 914767 /Source="Nicolas_upshifts" /id="U690" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig="0.994005994005994" /xcortree=1467 /SigmaFactorBS="ttattttgtcaaagagaaaaatgcatgagtttaactaaaata cagccccccgaaCATGGTATGATATTCAAAAAaagggggctttttttctgaaaacatt g" /listShort="ygaN, S310" /GFF_Attribute="listLong" /label="upshifts" CDS 914838..915374 /gene="ygaN" /locus_tag="BSU_08870" /old_locus_tag="BSU08870" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12193636, 16513748; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sulfur-related oxidoreductase" /protein_id="NP_388767.1" /db_xref="EnsemblGenomes-Gn:BSU08870" /db_xref="EnsemblGenomes-Tr:CAB12715" /db_xref="SubtiList:BG12233" /db_xref="UniProtKB/Swiss-Prot:P97028" /translation="MLSACGHSKQMEIKAADISDLEKNRMDVAASQAFTAEAVNIGEG ISSADMYIEHYQKGKLVERFGPVRADYSEEKTDTIQFVYFENEEGEGKNKHTTIHFGI VDKQGTIAADSSVKRDDSTTQEMTQNISSPEPITFEKPALIGSSIRGTDETMHTSEHK KELIKHQDALLYYVELHH*" /label="ygaN CDS" gene 914838..915374 /gene="ygaN" /locus_tag="BSU_08870" /old_locus_tag="BSU08870" /label="ygaN gene" S_feature 915375..915445 /Source="Nicolas_S_feature" /locus_tag="new_965798_965868" /HighExp="B36, BT, B60, Etha, S5, Heat, S2, BMM, S4, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.25357200000000002" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S310" promotor_-35 915415..915422 /Source="Nicolas_upshift_promotors" /id="U691" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.718281718281718" /psig="0.999000999001" /xcortree=664 /SigmaFactorBS="caggccgtctgttttacaaagcggtatgCTTGCTTTtttgaa tggtgaaTGATACATTTTAAATCGTAAcaatttcgatttaaagggaggctatgtgact t" /listShort="rpsNB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 915436..915455 /Source="Nicolas_upshift_promotors" /id="U691" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.718281718281718" /psig="0.999000999001" /xcortree=664 /SigmaFactorBS="caggccgtctgttttacaaagcggtatgCTTGCTTTtttgaa tggtgaaTGATACATTTTAAATCGTAAcaatttcgatttaaagggaggctatgtgact t" /listShort="rpsNB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 915447 /Source="Nicolas_upshifts" /id="U691" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.718281718281718" /psig="0.999000999001" /xcortree=664 /SigmaFactorBS="caggccgtctgttttacaaagcggtatgCTTGCTTTtttgaa tggtgaaTGATACATTTTAAATCGTAAcaatttcgatttaaagggaggctatgtgact t" /listShort="rpsNB" /GFF_Attribute="listLong" /label="upshifts" CDS 915486..915755 /gene="rpsNB" /locus_tag="BSU_08880" /old_locus_tag="BSU08880" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12904577, 17163968, 19648245, 20208344, 27561249; Product type f: factor" /codon_start=1 /transl_table=11 /product="alternative ribosomal protein S14" /protein_id="NP_388768.1" /db_xref="EnsemblGenomes-Gn:BSU08880" /db_xref="EnsemblGenomes-Tr:CAB12716" /db_xref="GOA:O31587" /db_xref="InterPro:IPR001209" /db_xref="InterPro:IPR018271" /db_xref="InterPro:IPR023036" /db_xref="SubtiList:BG13085" /db_xref="UniProtKB/Swiss-Prot:O31587" /translation="MAKKSKVAKELKRQQLVEQYAGIRRELKEKGDYEALSKLPRDSA PGRLHNRCMVTGRPRAYMRKFKMSRIAFRELAHKGQIPGVKKASW*" /label="rpsNB CDS" gene 915486..915755 /gene="rpsNB" /locus_tag="BSU_08880" /old_locus_tag="BSU08880" /label="rpsNB gene" promotor_-35 915558..915562 /Source="Nicolas_upshift_promotors" /id="U692" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.62037962037962" /psig="0.020979020979021" /xcortree=654 /SigmaFactorBS="aatacgctggtattagaCGCGAgttgaaggaaaaaggagatt acGAGGCACTCAGCAAGCTgccaagagattcagcaccgggaaggcttcacaaccgctg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 915585..915601 /Source="Nicolas_upshift_promotors" /id="U692" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.62037962037962" /psig="0.020979020979021" /xcortree=654 /SigmaFactorBS="aatacgctggtattagaCGCGAgttgaaggaaaaaggagatt acGAGGCACTCAGCAAGCTgccaagagattcagcaccgggaaggcttcacaaccgctg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 915601 /Source="Nicolas_upshifts" /id="U692" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.62037962037962" /psig="0.020979020979021" /xcortree=654 /SigmaFactorBS="aatacgctggtattagaCGCGAgttgaaggaaaaaggagatt acGAGGCACTCAGCAAGCTgccaagagattcagcaccgggaaggcttcacaaccgctg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 915742 /Source="Nicolas_upshifts" /id="D452" /incds=0 /nref=41 /ntot=70 /MaxReadThrough="3.14088" /MaxDrop="6.23701" /score="18.4402235" /energy="-10.1" /TU="U692" /idTUdmin="U691" /TUdmin="-13" /isTUend="TRUE" /label="downshifts" CDS complement(915773..916246) /gene="ygaO" /locus_tag="BSU_08890" /old_locus_tag="BSU08890" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388769.1" /db_xref="EnsemblGenomes-Gn:BSU08890" /db_xref="EnsemblGenomes-Tr:CAB12717" /db_xref="GOA:P97029" /db_xref="SubtiList:BG12234" /db_xref="UniProtKB/Swiss-Prot:P97029" /translation="MSMKTKAAFHLVLFGLACWALISYFEASEGIASFFGTKSGGMVF DLNLTPFILFVAASAVYLYLQKKSRPARKQLLLPDEFEEQDEREQMMTAKACRASYIA VYFSLPAAAVLLIFYPLFQSRIPFFPIIIVFIIMIIQHLSYVISFKKNEKNSGAL*" /label="ygaO CDS" gene complement(915773..916246) /gene="ygaO" /locus_tag="BSU_08890" /old_locus_tag="BSU08890" /label="ygaO gene" downshifts complement(915809) /Source="Nicolas_upshifts" /id="D453" /incds=0 /nref=105 /ntot=235 /MaxReadThrough="1.59724" /MaxDrop="4.17785" /score="7.33161195" /energy="-10.1" /TU="NA" /idTUdmin="U693" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(916248..916448) /gene="ygzD" /locus_tag="BSU_08899" /old_locus_tag="BSU08899" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative HTH-type transcriptional regulator" /protein_id="YP_003097697.1" /db_xref="EnsemblGenomes-Gn:BSU08899" /db_xref="EnsemblGenomes-Tr:CAX52584" /db_xref="GOA:C0H3X9" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010982" /db_xref="UniProtKB/Swiss-Prot:C0H3X9" /translation="MKNKVKELRARFGYSQEKLGETVGVTRQTVAAIEKGDYVPSLLL ALKICKAFSMKMEDVFWLEEEN*" /label="ygzD CDS" gene complement(916248..916448) /gene="ygzD" /locus_tag="BSU_08899" /old_locus_tag="BSU08899" /label="ygzD gene" promotor_-10 complement(916477..916496) /Source="Nicolas_upshift_promotors" /id="U693" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.626373626373626" /psig="0.996003996003996" /xcortree=1780 /SigmaFactorBS="aaaaaaagttatctttttgtaaagttgttaagttcCATTTAC AtaatgttaagtaTACTATACAATATAATCAATcgagattgtgaaggggacagacgtc a" /listShort="ygzD, ygaO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(916491) /Source="Nicolas_upshifts" /id="U693" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.626373626373626" /psig="0.996003996003996" /xcortree=1780 /SigmaFactorBS="aaaaaaagttatctttttgtaaagttgttaagttcCATTTAC AtaatgttaagtaTACTATACAATATAATCAATcgagattgtgaaggggacagacgtc a" /listShort="ygzD, ygaO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(916509..916516) /Source="Nicolas_upshift_promotors" /id="U693" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.626373626373626" /psig="0.996003996003996" /xcortree=1780 /SigmaFactorBS="aaaaaaagttatctttttgtaaagttgttaagttcCATTTAC AtaatgttaagtaTACTATACAATATAATCAATcgagattgtgaaggggacagacgtc a" /listShort="ygzD, ygaO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 916572..916577 /Source="Nicolas_upshift_promotors" /id="U694" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.35964035964036" /psig=1 /xcortree=2589 /SigmaFactorBS="tacaaaaagataactttttttcgacaaaatttttatattccC TTGACgaaaaataaataaACATGTAATATAAAAAAAGTcagagcggtactgttgctga c" /listShort="trnSL-Gly1, S311, S312, yhbA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 916591..916610 /Source="Nicolas_upshift_promotors" /id="U694" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.35964035964036" /psig=1 /xcortree=2589 /SigmaFactorBS="tacaaaaagataactttttttcgacaaaatttttatattccC TTGACgaaaaataaataaACATGTAATATAAAAAAAGTcagagcggtactgttgctga c" /listShort="trnSL-Gly1, S311, S312, yhbA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 916591 /Source="Nicolas_upshifts" /id="U694" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.35964035964036" /psig=1 /xcortree=2589 /SigmaFactorBS="tacaaaaagataactttttttcgacaaaatttttatattccC TTGACgaaaaataaataaACATGTAATATAAAAAAAGTcagagcggtactgttgctga c" /listShort="trnSL-Gly1, S311, S312, yhbA" /GFF_Attribute="listLong" /label="upshifts" tRNA 916642..916715 /gene="trnSL-Gly1" /locus_tag="BSU_tRNA_82" /product="tRNA-Gly" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Gly(TCC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Gly1 tRNA" gene 916642..916715 /gene="trnSL-Gly1" /locus_tag="BSU_tRNA_82" /label="trnSL-Gly1 gene" S_feature 916716..916898 /Source="Nicolas_S_feature" /locus_tag="new_967139_967321" /HighExp="G135, G180, Oxctl, G150, Paraq, H2O2, C30, HPh, LPh, LBGexp" /AntisenseName="yhzB" /AntisenseCor="0.42714037049296899" /AntisenseRegPval="-12.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S311" CDS complement(916806..917429) /gene="yhzB" /locus_tag="BSU_08900" /old_locus_tag="BSU08900" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388771.1" /db_xref="EnsemblGenomes-Gn:BSU08900" /db_xref="EnsemblGenomes-Tr:CAB12718" /db_xref="InterPro:IPR020825" /db_xref="SubtiList:BG13086" /db_xref="UniProtKB/Swiss-Prot:O31588" /translation="MNIKLDSVITERAAGLHAAAVIYENIEVGSSPQMLKGRLRLFQE SLFFDYADGGISDESFVKEWQKLFKQLNPSFEGETTPMEDMLVPISKEQFMESKDSAH DTIDFFALKYSLPIMIYDAGKLHEPVRISLGEKENILLFSDENGIFGDFKNSVNHYPV SNETKNMLQIIFFPPSIEKSSAVNLLSSLTKMFEQIHGGTHTVHWLT*" /label="yhzB CDS" gene complement(916806..917429) /gene="yhzB" /locus_tag="BSU_08900" /old_locus_tag="BSU08900" /label="yhzB gene" downshifts complement(916821) /Source="Nicolas_upshifts" /id="D454" /incds=0 /nref=25 /ntot=165 /MaxReadThrough="2.50849" /MaxDrop="4.62652" /score="-8.52782087" /energy="-7.9" /TU="NA" /idTUdmin="U695" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 916855 /Source="Nicolas_upshifts" /id="D455" /incds=0 /nref=1 /ntot=88 /MaxReadThrough="4.14204" /MaxDrop="2.36986" /score="16.0836885" /energy="-15.5" /TU="U694" /idTUdmin="U692" /TUdmin=1078 /isTUend="FALSE" /label="downshifts" S_feature 916900..917511 /Source="Nicolas_S_feature" /locus_tag="new_967323_967934" /HighExp="G180, G135, G150, Paraq, Oxctl, H2O2, LBGstat, Cold, LBGexp, S6" /AntisenseName="yhzB" /AntisenseCor="0.28959466335762701" /AntisenseRegPval="-5.9" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S312" promotor_-10 complement(917453..917472) /Source="Nicolas_upshift_promotors" /id="U695" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.631368631368631" /psig="0.999000999001" /xcortree=1953 /SigmaFactorBS="tctttgagctgataaacgttcatgttttgcacagcctccttT CTTTGTGataaaacgacacaGCGTTTATAATAGGTTGATAtcacgtaactggagtgaa t" /listShort="yhzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(917474) /Source="Nicolas_upshifts" /id="U695" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.631368631368631" /psig="0.999000999001" /xcortree=1953 /SigmaFactorBS="tctttgagctgataaacgttcatgttttgcacagcctccttT CTTTGTGataaaacgacacaGCGTTTATAATAGGTTGATAtcacgtaactggagtgaa t" /listShort="yhzB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(917486..917493) /Source="Nicolas_upshift_promotors" /id="U695" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.631368631368631" /psig="0.999000999001" /xcortree=1953 /SigmaFactorBS="tctttgagctgataaacgttcatgttttgcacagcctccttT CTTTGTGataaaacgacacaGCGTTTATAATAGGTTGATAtcacgtaactggagtgaa t" /listShort="yhzB" /GFF_Attribute="listLong" /label="promotor_-35" CDS 917512..918672 /gene="queG" /locus_tag="BSU_08910" /old_locus_tag="BSU08910" /EC_number="1.17.99.-" /function="10.3: tRNA and rRNA base modification" /experiment="publication(s) with functional evidences, PMID:8830270, 21502530, 26230193, 27638883, 28128549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8830270, 21502530, 26230193, 27638883, 28128549; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="epoxyqueuosine reductase" /protein_id="NP_388772.2" /db_xref="EnsemblGenomes-Gn:BSU08910" /db_xref="EnsemblGenomes-Tr:CAB12719" /db_xref="GOA:P97030" /db_xref="InterPro:IPR004155" /db_xref="InterPro:IPR004453" /db_xref="InterPro:IPR013542" /db_xref="InterPro:IPR016024" /db_xref="InterPro:IPR017896" /db_xref="InterPro:IPR017900" /db_xref="PDB:5D08" /db_xref="PDB:5D0A" /db_xref="PDB:5D0B" /db_xref="PDB:5T8Y" /db_xref="SubtiList:BG12236" /db_xref="UniProtKB/Swiss-Prot:P97030" /translation="MNVYQLKEELIEYAKSIGVDKIGFTTADTFDSLKDRLILQESLG YLSGFEEPDIEKRVTPKLLLPKAKSIVAIALAYPSRMKDAPRSTRTERRGIFCRASWG KDYHDVLREKLDLLEDFLKSKHEDIRTKSMVDTGELSDRAVAERAGIGFSAKNCMITT PEYGSYVYLAEMITNIPFEPDVPIEDMCGSCTKCLDACPTGALVNPGQLNAQRCISFL TQTKGFLPDEFRTKIGNRLYGCDTCQTVCPLNKGKDFHLHPEMEPDPEIAKPLLKPLL AISNREFKEKFGHVSGSWRGKKPIQRNAILALAHFKDASALPELTELMHKDPRPVIRG TAAWAIGKIGDPAYAEELEKALEKEKDEEAKLEIEKGIELLKASGMTKQGLS*" /label="queG CDS" gene 917512..918672 /gene="queG" /locus_tag="BSU_08910" /old_locus_tag="BSU08910" /label="queG gene" downshifts 918681 /Source="Nicolas_upshifts" /id="D456" /incds=0 /nref=9 /ntot=123 /MaxReadThrough="5.29174" /MaxDrop="3.3561" /score="33.0421154" /energy="-15.1" /TU="NA" /idTUdmin="U694" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature 918698..918710 /Source="Nicolas_upshift_promotors" /id="U696" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.909090909090909" /psig="0.909090909090909" /xcortree=1143 /SigmaFactorBS="tcaggcatgactaaacaaggcctgtcctgacatacgtataga gcagaaggaaaaaACACTTGAGATCAtccaagtgttttttctctataaaaaagtatgg c" /listShort="yhbB, cspR" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 918703 /Source="Nicolas_upshifts" /id="U696" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.909090909090909" /psig="0.909090909090909" /xcortree=1143 /SigmaFactorBS="tcaggcatgactaaacaaggcctgtcctgacatacgtataga gcagaaggaaaaaACACTTGAGATCAtccaagtgttttttctctataaaaaagtatgg c" /listShort="yhbB, cspR" /GFF_Attribute="listLong" /label="upshifts" CDS 918739..919674 /gene="yhbB" /locus_tag="BSU_08920" /old_locus_tag="BSU08920" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388773.1" /db_xref="EnsemblGenomes-Gn:BSU08920" /db_xref="EnsemblGenomes-Tr:CAB12720" /db_xref="InterPro:IPR024301" /db_xref="SubtiList:BG11811" /db_xref="UniProtKB/Swiss-Prot:O31589" /translation="MAGGVSLKYILEQLAEERLGFLVNGHAMRQESQVGDLKVMERKK KLLEKRKVDIIKAKAKAVINHVRVEDDGTTCLSYTIHYEYVCKEQDDSLYIEEHIEER MAFLYDHILISDQEIAKKPAGFHEGTSIIDYSEAEEEREAFGRAFQYDRLGAVQYAEK FWNKRNPAYKNFSDNCTNFISQCLHAGGAPMRGHPNRGSGWWMKQSSWSYSWTVAHSM KMYLSNSKAGLRAVRVKSAEELMPGDVICYDFEGDGRFNHTTIVVAKDKGNMPLVNAQ TYDSRMRYWSYEDSTAYTPSIRYAFFHIVDDTTKE*" /label="yhbB CDS" gene 918739..919674 /gene="yhbB" /locus_tag="BSU_08920" /old_locus_tag="BSU08920" /label="yhbB gene" downshifts complement(918757) /Source="Nicolas_upshifts" /id="D457" /incds=0 /nref=2 /ntot=17 /MaxReadThrough="2.06584" /MaxDrop="3.33944" /score="-3.35852865" /energy="-6" /TU="NA" /idTUdmin="U695" /TUdmin="-1936" /isTUend="FALSE" /label="downshifts" promotor_-35 919658..919661 /Source="Nicolas_upshift_promotors" /id="U697" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.692307692307692" /psig=1 /xcortree=2502 /SigmaFactorBS="acacgccgtcaatacgatatgccttttttcatatcgttgatg ATACgacaaaagagtaattAATGTTATAATGATGGGCGGataagaaaaacagaggtga a" /listShort="cspR" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 919676 /Source="Nicolas_upshifts" /id="U697" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.692307692307692" /psig=1 /xcortree=2502 /SigmaFactorBS="acacgccgtcaatacgatatgccttttttcatatcgttgatg ATACgacaaaagagtaattAATGTTATAATGATGGGCGGataagaaaaacagaggtga a" /listShort="cspR" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 919677..919696 /Source="Nicolas_upshift_promotors" /id="U697" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.692307692307692" /psig=1 /xcortree=2502 /SigmaFactorBS="acacgccgtcaatacgatatgccttttttcatatcgttgatg ATACgacaaaagagtaattAATGTTATAATGATGGGCGGataagaaaaacagaggtga a" /listShort="cspR" /GFF_Attribute="listLong" /label="promotor_-10" CDS 919712..920194 /gene="trmL" /locus_tag="BSU_08930" /old_locus_tag="BSU08930" /EC_number="2.1.1.207" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 20855540; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA (cytidine(34)-2'-O)-methyltransferase" /protein_id="NP_388774.2" /db_xref="EnsemblGenomes-Gn:BSU08930" /db_xref="EnsemblGenomes-Tr:CAB12721" /db_xref="GOA:O31590" /db_xref="InterPro:IPR001537" /db_xref="InterPro:IPR016914" /db_xref="InterPro:IPR029026" /db_xref="InterPro:IPR029028" /db_xref="SubtiList:BG11802" /db_xref="UniProtKB/Swiss-Prot:O31590" /translation="MNIVALHVVLYQPEIPANTGNIARTCAATNTTLHLIRPLGFSTD DKMLKRAGLDYWEFVNVVYHDSLEELFEAYKKGKFFFITKFGQQPHTSFDYTDLDEDY FFVFGRETSGLPKDLIQNNMDRCLRLPMTEHVRSLNLSNTAAILVYEALRQQNYRDLK *" /label="trmL CDS" gene 919712..920194 /gene="trmL" /locus_tag="BSU_08930" /old_locus_tag="BSU08930" /label="trmL gene" downshifts 920177 /Source="Nicolas_upshifts" /id="D458" /incds=0 /nref=203 /ntot=259 /MaxReadThrough="4.6846" /MaxDrop="7.03587" /score="33.0421154" /energy="-15.1" /TU="NA" /idTUdmin="U696" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 920244..920960 /gene="yhbD" /locus_tag="BSU_08940" /old_locus_tag="BSU08940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative sporulation-related protein" /protein_id="NP_388775.1" /db_xref="EnsemblGenomes-Gn:BSU08940" /db_xref="EnsemblGenomes-Tr:CAB12722" /db_xref="InterPro:IPR025063" /db_xref="SubtiList:BG12237" /db_xref="UniProtKB/Swiss-Prot:P97032" /translation="MLCFVFGLNNVTVLCYNVPIKGAGLMEEQLISKKELLERTSISY GQLYRWKRKNLIPEEWFIRKSTFTGQETFFPREEILKRISMIQKMKENLSLDEMREML SPKMKDVSMTADELLHKGLVSRPALEAYSEDGGSPVFSSSDLLSLFVLEGLLQSGNVS LAEAKMAAEVLKKHDTEEIEKQTELIVLRKLGVTTCFIAAAADSILFESSVKVVERVD LLKASEELKTTFMQEGHQWM*" /label="yhbD CDS" gene 920244..920960 /gene="yhbD" /locus_tag="BSU_08940" /old_locus_tag="BSU08940" /label="yhbD gene" promotor_-35 920264..920271 /Source="Nicolas_upshift_promotors" /id="U698" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.761238761238761" /psig=1 /xcortree=2394 /SigmaFactorBS="tttttgcggatgttgaaatgctttgtttcgtttttggGCTTA ACAacgtaacagtgttaTGTTACAATGTACCCATCAAaggagctggacttatggaaga a" /listShort="yhbD, yhbE, yhbF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 920286..920305 /Source="Nicolas_upshift_promotors" /id="U698" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.761238761238761" /psig=1 /xcortree=2394 /SigmaFactorBS="tttttgcggatgttgaaatgctttgtttcgtttttggGCTTA ACAacgtaacagtgttaTGTTACAATGTACCCATCAAaggagctggacttatggaaga a" /listShort="yhbD, yhbE, yhbF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 920287 /Source="Nicolas_upshifts" /id="U698" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.761238761238761" /psig=1 /xcortree=2394 /SigmaFactorBS="tttttgcggatgttgaaatgctttgtttcgtttttggGCTTA ACAacgtaacagtgttaTGTTACAATGTACCCATCAAaggagctggacttatggaaga a" /listShort="yhbD, yhbE, yhbF" /GFF_Attribute="listLong" /label="upshifts" CDS 920951..921664 /gene="yhbE" /locus_tag="BSU_08950" /old_locus_tag="BSU08950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12562816, 20617312; Product type cp:cell process" /codon_start=1 /transl_table=11 /product="conserved protein involved in sporulation" /protein_id="NP_388776.1" /db_xref="EnsemblGenomes-Gn:BSU08950" /db_xref="EnsemblGenomes-Tr:CAB12723" /db_xref="InterPro:IPR007607" /db_xref="SubtiList:BG10802" /db_xref="UniProtKB/Swiss-Prot:P39132" /translation="MDVVEKLVINGSGSSKGGTFQSVEINGSGTVAGDVECDTFSFNG NGKADGSVKAKAVTISGSGKIHGDVEAESIRMNGTGFIQGEVSAKQLKIAGSSTFGGT VKADGIDISGKAVMEADCETETFQSEGKCKISGLLNADQVIIKLSAGESYAREIGCRH LQVTCRKGMLTLLRLMPQPVLTAELIEGDVIELTNTKAKTVRGNKVIIGPDCQIETVE YSGDYTCDPSASVETSTKL*" /label="yhbE CDS" gene 920951..921664 /gene="yhbE" /locus_tag="BSU_08950" /old_locus_tag="BSU08950" /label="yhbE gene" CDS 921676..922383 /gene="yhbF" /locus_tag="BSU_08960" /old_locus_tag="BSU08960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12562816, 20617312; Product type cp:cell process" /codon_start=1 /transl_table=11 /product="conserved protein involved in sporulation" /protein_id="NP_388777.2" /db_xref="EnsemblGenomes-Gn:BSU08960" /db_xref="EnsemblGenomes-Tr:CAB12724" /db_xref="SubtiList:BG10803" /db_xref="UniProtKB/Swiss-Prot:P39133" /translation="METTKLGNLKLYGAGHAAGGAYHNVSIKGEGIVGEGLSAVGCRI YGTGLFLGKAETERLRVLGESECKGDLTAGKINIYGTMKVSGSLQFDRFNLKGQTEIG GNMTGESCDVKGKLSVIGDCETEMFHVTGCVDVSGLLNSGEIKLGLSHDISHVQEIGG TTITVKRRASFFSRKKGKLIADVIEGDRVYLENTEAAVVRGKEVIIGPGCSIGTIEYE YKCECDPHSQIKEKTKL*" /label="yhbF CDS" gene 921676..922383 /gene="yhbF" /locus_tag="BSU_08960" /old_locus_tag="BSU08960" /label="yhbF gene" downshifts 922267 /Source="Nicolas_upshifts" /id="D459" /incds=1 /nref=1 /ntot=127 /MaxReadThrough="4.34704" /MaxDrop="2.64409" /score="45.497414" /energy="-15.3" /TU="U698" /idTUdmin="U698" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" downshifts 922311 /Source="Nicolas_upshifts" /id="D460" /incds=1 /nref=2 /ntot=35 /MaxReadThrough="4.02504" /MaxDrop="3.21894" /score="45.497414" /energy="-15.3" /TU="U698" /idTUdmin="U698" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" downshifts 922377 /Source="Nicolas_upshifts" /id="D461" /incds=0 /nref=2 /ntot=41 /MaxReadThrough="1.06365" /MaxDrop="3.74046" /score="45.497414" /energy="-15.3" /TU="NA" /idTUdmin="U698" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(922410..922585) /Source="Nicolas_S_feature" /locus_tag="new_972833_973008_c" /HighExp="M9-stat, BC, S4, T0.30H, LoTm, Lbstat, S2, BT, HiOs, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99846699999999999" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S313" downshifts complement(922453) /Source="Nicolas_upshifts" /id="D462" /incds=0 /nref=63 /ntot=220 /MaxReadThrough="3.38525" /MaxDrop="4.33005" /score="18.2489321" /energy="-13.5" /TU="U699" /idTUdmin="U699" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(922577..922596) /Source="Nicolas_upshift_promotors" /id="U699" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.653346653346653" /psig="0.998001998001998" /xcortree=456 /SigmaFactorBS="tttcttaaaaataaagatactcatacaTCGTTGACaaggcag actgcgaCCGTTCATAATAAAGAAAAAtacagaatcatccagactcggacagcacgga a" /listShort="S313" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(922585) /Source="Nicolas_upshifts" /id="U699" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.653346653346653" /psig="0.998001998001998" /xcortree=456 /SigmaFactorBS="tttcttaaaaataaagatactcatacaTCGTTGACaaggcag actgcgaCCGTTCATAATAAAGAAAAAtacagaatcatccagactcggacagcacgga a" /listShort="S313" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(922611..922618) /Source="Nicolas_upshift_promotors" /id="U699" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.653346653346653" /psig="0.998001998001998" /xcortree=456 /SigmaFactorBS="tttcttaaaaataaagatactcatacaTCGTTGACaaggcag actgcgaCCGTTCATAATAAAGAAAAAtacagaatcatccagactcggacagcacgga a" /listShort="S313" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 922650..922655 /Source="Nicolas_upshift_promotors" /id="U700" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1094 /SigmaFactorBS="gtcaacgatgtatgagtatctttatttttaagaaaccaaAGC ATGtatcacgagatggcgGCATAGATTGTATCAAAGTaccttatttgcatagtgtatc a" /listShort="prkA, S314, yhbH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 922671..922689 /Source="Nicolas_upshift_promotors" /id="U700" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1094 /SigmaFactorBS="gtcaacgatgtatgagtatctttatttttaagaaaccaaAGC ATGtatcacgagatggcgGCATAGATTGTATCAAAGTaccttatttgcatagtgtatc a" /listShort="prkA, S314, yhbH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 922671 /Source="Nicolas_upshifts" /id="U700" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1094 /SigmaFactorBS="gtcaacgatgtatgagtatctttatttttaagaaaccaaAGC ATGtatcacgagatggcgGCATAGATTGTATCAAAGTaccttatttgcatagtgtatc a" /listShort="prkA, S314, yhbH" /GFF_Attribute="listLong" /label="upshifts" CDS 922733..924628 /gene="prkA" /locus_tag="BSU_08970" /old_locus_tag="BSU08970" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8626065, 12662922, 25983726, 27806131" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8626065, 12662922, 25983726, 27806131; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="serine protein kinase (involved in sporulation)" /protein_id="NP_388778.1" /db_xref="EnsemblGenomes-Gn:BSU08970" /db_xref="EnsemblGenomes-Tr:CAB12725" /db_xref="GOA:P39134" /db_xref="InterPro:IPR010650" /db_xref="InterPro:IPR013153" /db_xref="InterPro:IPR016230" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10804" /db_xref="UniProtKB/Swiss-Prot:P39134" /translation="MDILKKIEKYREEEQRLKWEGTFADYLEIIKENPMVAQSAHSRV FNMIKDSGIEEIDGRKKYSFFDRELFGLEESLERLVEEYFHPAAKRLDVRKRILLLMG PVSGGKSTLVTMLKKGLEAYTLTDNGAVYAIKGCPMHEDPLHLIPHHLRDDFYREYGI RIEGSLSPLNVMRLEEEYGGRIEDVKVERIFFSEDKRTGIGTFSPSDPKSQDIADLTG SIDFSTIAEYGSESDPRAYRFDGELNKANRGMMEFQEMLKCDEKFLWHLLSLTQEGNF KAGRFALISADELIVAHTNETEYRSFISNKKNEALHSRIIVMPVPYNLKVSEEERIYE KMIAESDVADVHIAPHTLKVAAMFSILTRLKEPKRSDIDLVKKMRLYDGESVEGYNSV DVEDMKKEYNDEGMSGIDPRYVINRISSTIIRKNMESINSLDVLRSLKEGLDQHPSIS SEDRERYLNFISAARKEYDDIAKKEVQKAFVYSYEESAKTLMDNYLDNVEAYCNKNKL RDPLTGEEMNPDEKLMRSIEEQIGISENAKKAFREEILIRISAYARKGKRFDYNSHER LREAIQKKLFADLKDVVKITTSTKTPDEQQLKKVNEVVARLIDEHGYNSTSANELLKY VGSLLNR*" /label="prkA CDS" gene 922733..924628 /gene="prkA" /locus_tag="BSU_08970" /old_locus_tag="BSU08970" /label="prkA gene" promotor_no_box 923175..923275 /Source="Nicolas_upshift_promotors" /id="U701" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.31968031968032" /psig="0.31968031968032" /xcortree=684 /SigmaFactorBS="atcatttacgcgatgacttttacagagaatacggcattagaa tagaaggaagtctttctcctttaaatgtcatgaggctggaggaagagtacggaggaag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 923235 /Source="Nicolas_upshifts" /id="U701" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.31968031968032" /psig="0.31968031968032" /xcortree=684 /SigmaFactorBS="atcatttacgcgatgacttttacagagaatacggcattagaa tagaaggaagtctttctcctttaaatgtcatgaggctggaggaagagtacggaggaag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 923301 /Source="Nicolas_upshifts" /id="D463" /incds=1 /nref=5 /ntot=18 /MaxReadThrough="7.33384" /MaxDrop="5.65132" /score="45.497414" /energy="-15.3" /TU="U700" /idTUdmin="U701" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 924621 /Source="Nicolas_upshifts" /id="D464" /incds=0 /nref=11 /ntot=57 /MaxReadThrough="6.19375" /MaxDrop="4.381" /score="-0.497429548" /energy="-10.6" /TU="U700" /idTUdmin="U703" /TUdmin="-528" /isTUend="FALSE" /label="downshifts" promotor_-35 924685..924690 /Source="Nicolas_upshift_promotors" /id="U702" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1058 /SigmaFactorBS="agggcgggttattttgtcccattttctaaatagtttGTCAAT taaacgtgcatatgtGCATATGATGAATATAAATcttttcaaaagacttgtttcataa t" /listShort="S314, yhbH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 924706..924724 /Source="Nicolas_upshift_promotors" /id="U702" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1058 /SigmaFactorBS="agggcgggttattttgtcccattttctaaatagtttGTCAAT taaacgtgcatatgtGCATATGATGAATATAAATcttttcaaaagacttgtttcataa t" /listShort="S314, yhbH" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 924709..924807 /Source="Nicolas_S_feature" /locus_tag="new_975132_975230" /HighExp="S6, S7, S5, S8, S4, S3, BT, LoTm, B36, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigEF" /TUshortPSig="0.971, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S314" upshifts 924709 /Source="Nicolas_upshifts" /id="U702" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1058 /SigmaFactorBS="agggcgggttattttgtcccattttctaaatagtttGTCAAT taaacgtgcatatgtGCATATGATGAATATAAATcttttcaaaagacttgtttcataa t" /listShort="S314, yhbH" /GFF_Attribute="listLong" /label="upshifts" CDS 924808..925986 /gene="yhbH" /locus_tag="BSU_08980" /old_locus_tag="BSU08980" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11988534, 12662922, 14523133, 25983726" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11988534, 12662922, 14523133, 25983726; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor involved in shape determination" /protein_id="NP_388779.1" /db_xref="EnsemblGenomes-Gn:BSU08980" /db_xref="EnsemblGenomes-Tr:CAB12726" /db_xref="InterPro:IPR006698" /db_xref="InterPro:IPR014230" /db_xref="SubtiList:BG11238" /db_xref="UniProtKB/Swiss-Prot:P45742" /translation="MSQNDSGHFLISEENWSLHRKGFDDQQRHQKKVQEAIKNNLPDL VTEESIIMSNGKDVVKIPIRSLDEYKIRYNYDKNKHVGQGDGESQVGDVVARDGSDKK QGPGKGQGAGDQAGEDYYEAEVSLMDLEEALFKELELPNLQQKERDNIIHTDIEFNDI RKTGLTGNIDKKRTMMSAFKRNAMSGKPSFYPIYPEDLKYKTWNDITKPESKAVVLAM MDTSGSMGVWEKYMARSFFFWMTRFLRTKYETVEIEFIAHHTEARVVSEEDFFSKGES GGTICSSVYRKSLELIDEKYNPARYNIYPFHFSDGDNLTSDNARCVKLVNDIMKKANL FCYGEVNQYNRHSTLMSAYKNVKDEKFKYYILKQKSDVFQALKNFFRNEESGVSHQFS *" /label="yhbH CDS" gene 924808..925986 /gene="yhbH" /locus_tag="BSU_08980" /old_locus_tag="BSU08980" /label="yhbH gene" promotor_-35 925006..925009 /Source="Nicolas_upshift_promotors" /id="U703" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.367632367632368" /psig="0.985014985014985" /xcortree=615 /SigmaFactorBS="atggaaaagatgtagtgaagatcccaatccgttcacttGATG agtataaaatccgtTATAACTATGATAAAAATAAacatgtagggcaaggagacggcga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 925024..925043 /Source="Nicolas_upshift_promotors" /id="U703" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.367632367632368" /psig="0.985014985014985" /xcortree=615 /SigmaFactorBS="atggaaaagatgtagtgaagatcccaatccgttcacttGATG agtataaaatccgtTATAACTATGATAAAAATAAacatgtagggcaaggagacggcga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 925028 /Source="Nicolas_upshifts" /id="U703" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.367632367632368" /psig="0.985014985014985" /xcortree=615 /SigmaFactorBS="atggaaaagatgtagtgaagatcccaatccgttcacttGATG agtataaaatccgtTATAACTATGATAAAAATAAacatgtagggcaaggagacggcga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(925269) /Source="Nicolas_upshifts" /id="D465" /incds=1 /nref=1 /ntot=23 /MaxReadThrough="2.79078" /MaxDrop="2.94521" /score="-7.1109433" /energy="-11.2" /TU="NA" /idTUdmin="U699" /TUdmin="-3014" /isTUend="FALSE" /label="downshifts" downshifts 925965 /Source="Nicolas_upshifts" /id="D466" /incds=0 /nref=63 /ntot=180 /MaxReadThrough="1.86673" /MaxDrop="8.19565" /score="27.3980811" /energy="-5.6" /TU="NA" /idTUdmin="U702" /TUdmin=2 /isTUend="TRUE" /label="downshifts" promotor_-35 926073..926080 /Source="Nicolas_upshift_promotors" /id="U704" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.754245754245754" /psig="0.996003996003996" /xcortree=2450 /SigmaFactorBS="cgcttgcgaaaaaaatacgggagaaaaagaaatttttcCTTT GACAaatcttctttcattTATTAATATTTTATCTTGTGaactattattgaggaatgag g" /listShort="yhbI, yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 926095..926114 /Source="Nicolas_upshift_promotors" /id="U704" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.754245754245754" /psig="0.996003996003996" /xcortree=2450 /SigmaFactorBS="cgcttgcgaaaaaaatacgggagaaaaagaaatttttcCTTT GACAaatcttctttcattTATTAATATTTTATCTTGTGaactattattgaggaatgag g" /listShort="yhbI, yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 926095 /Source="Nicolas_upshifts" /id="U704" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.754245754245754" /psig="0.996003996003996" /xcortree=2450 /SigmaFactorBS="cgcttgcgaaaaaaatacgggagaaaaagaaatttttcCTTT GACAaatcttctttcattTATTAATATTTTATCTTGTGaactattattgaggaatgag g" /listShort="yhbI, yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" /label="upshifts" CDS 926146..926610 /gene="yhbI" /locus_tag="BSU_08990" /old_locus_tag="BSU08990" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20011599; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MarR family)induced by acid stress" /protein_id="NP_388780.1" /db_xref="EnsemblGenomes-Gn:BSU08990" /db_xref="EnsemblGenomes-Tr:CAB12727" /db_xref="GOA:O31592" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13003" /db_xref="UniProtKB/Swiss-Prot:O31592" /translation="MTESERALLTFEQLFDTSRAIYKKQKKILEIVLEPFDITVLQYL LMFKIHQSGSTPLSKLAMSLDLKPASVTRMTDILYKRQLMNRYDSPDDRRIVMIQLTE EGEELIEKAAVQYAKMGAGLYQKLDTSQLQYLRKLAGSLTKLAEGCSEKSGN*" /label="yhbI CDS" gene 926146..926610 /gene="yhbI" /locus_tag="BSU_08990" /old_locus_tag="BSU08990" /label="yhbI gene" promotor_-35 926435..926441 /Source="Nicolas_upshift_promotors" /id="U705" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.94005994005994" /psig="0.94005994005994" /xcortree=270 /SigmaFactorBS="cagtccggatgaccgccgtatcgtcaTGATTCAgttaaccga agaggGGGAAGAACTGATAGAAAAagccgctgtgcaatatgcaaaaatgggtgctggc t" /listShort="yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 926456..926474 /Source="Nicolas_upshift_promotors" /id="U705" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.94005994005994" /psig="0.94005994005994" /xcortree=270 /SigmaFactorBS="cagtccggatgaccgccgtatcgtcaTGATTCAgttaaccga agaggGGGAAGAACTGATAGAAAAagccgctgtgcaatatgcaaaaatgggtgctggc t" /listShort="yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 926469 /Source="Nicolas_upshifts" /id="U705" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.94005994005994" /psig="0.94005994005994" /xcortree=270 /SigmaFactorBS="cagtccggatgaccgccgtatcgtcaTGATTCAgttaaccga agaggGGGAAGAACTGATAGAAAAagccgctgtgcaatatgcaaaaatgggtgctggc t" /listShort="yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 926619..926625 /Source="Nicolas_upshift_promotors" /id="U706" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=808 /SigmaFactorBS="gctgttcagaaaaaagcggtaattaaaaacttctCACATATt ttcaccagctttCCGCAAAATGATagaggatgaaacgaaaggagaaaacaaaatgaac a" /listShort="yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 926639..926650 /Source="Nicolas_upshift_promotors" /id="U706" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=808 /SigmaFactorBS="gctgttcagaaaaaagcggtaattaaaaacttctCACATATt ttcaccagctttCCGCAAAATGATagaggatgaaacgaaaggagaaaacaaaatgaac a" /listShort="yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 926645 /Source="Nicolas_upshifts" /id="U706" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=808 /SigmaFactorBS="gctgttcagaaaaaagcggtaattaaaaacttctCACATATt ttcaccagctttCCGCAAAATGATagaggatgaaacgaaaggagaaaacaaaatgaac a" /listShort="yhbJ, yhcA, yhcB, yhcC" /GFF_Attribute="listLong" /label="upshifts" CDS 926646..927311 /gene="yhbJ" /locus_tag="BSU_09000" /old_locus_tag="BSU09000" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 20011599; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane fusion protein; putative exporter subunit (benzoate transcriptome)" /protein_id="NP_388781.1" /db_xref="EnsemblGenomes-Gn:BSU09000" /db_xref="EnsemblGenomes-Tr:CAB12728" /db_xref="GOA:O31593" /db_xref="InterPro:IPR011053" /db_xref="SubtiList:BG13004" /db_xref="UniProtKB/Swiss-Prot:O31593" /translation="MIEDETKGENKMNRGRLILTNIIGLIVVLAIIAGGAYYYYQSTN YVKTDEAKVAGDMAAITAPAAGKVSDWDLDEGKTVKKGDTVAKIKGEQTVDVKSIMDG TIVKNEVKNGQTVQAGTTIAQTIDMDNLYITANIKETDIADIEVGNSVDVVVDGDPDT TFDGTVEEIGYATNSTFDMLPSTNSSGNYTKVTQKVPVKISIKNPSDKVLPGMNASVK ISE*" /label="yhbJ CDS" gene 926646..927311 /gene="yhbJ" /locus_tag="BSU_09000" /old_locus_tag="BSU09000" /label="yhbJ gene" CDS 927352..928950 /gene="yhcA" /locus_tag="BSU_09010" /old_locus_tag="BSU09010" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 20011599; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative exporter (benzoate transcriptome)" /protein_id="NP_388782.1" /db_xref="EnsemblGenomes-Gn:BSU09010" /db_xref="EnsemblGenomes-Tr:CAB12729" /db_xref="GOA:P54585" /db_xref="InterPro:IPR004638" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11579" /db_xref="UniProtKB/Swiss-Prot:P54585" /translation="MATGKEKNAKNPMSLLIVLMAGLFLAILNQTLLNVAMPHLMTEF GVSATTIQWLTTGYMLVNGVLIPLSAFLITRFGQRSLFLVAMFCFTLGTLVCGIAPNF STMLIGRLIQAVGGGILQPLVMTTILLIFPPESRGKGMGIFGLAMMFAPAVGPTLSGW IIEHYTWRIMFYGLVPIGAIVIIVAFFIFKNMVEPQKIKLDTLGAILSIVGFASLLYG VSEAGSDGWTDPIVLSTVIIGAIAIVAFVVQQLRHDDPMLDFRVFKYDIFSLSSVINI IITVALYTGMFLLPIYLQNLVGFTALQSGLLLLPGAIVMLIMSPISGILFDKFGPRPL AIIGLLVTVVTTYQYTQLTIDTPYTHIMLIYSIRAFGMSLLMMPVMTAGMNQLPARLN SHGTAMSNTLRQISGSIGTSLITTIYTNRTTFHYSQIADKTSTADPNFLHAFQNAVSN LMVNMNVSYDTAKTYVYSHIYKHASLDSNVMGINDAFMWATLFCVAGLILSIFLRDVR KDKLRKKKKEELSLLPAPKEAKES*" /label="yhcA CDS" gene 927352..928950 /gene="yhcA" /locus_tag="BSU_09010" /old_locus_tag="BSU09010" /label="yhcA gene" CDS 928973..929503 /gene="yhcB" /locus_tag="BSU_09020" /old_locus_tag="BSU09020" /EC_number="1.6.5.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15754243, 18041955, 17951395, 19665595, 20011599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADH:quinone oxidoreductase associated to benzoate stress" /protein_id="NP_388783.1" /db_xref="EnsemblGenomes-Gn:BSU09020" /db_xref="EnsemblGenomes-Tr:CAB12730" /db_xref="GOA:P54586" /db_xref="InterPro:IPR005025" /db_xref="InterPro:IPR008254" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG11580" /db_xref="UniProtKB/Swiss-Prot:P54586" /translation="MKIYVVYDSEGEHTKVLAEAIAEGARENDAAEVFIDHVDQADIR KLKDMDAIIWGCPGHFGTISSGLKTWIDRLGYLWAEGELINKVGAVFCTTATTHGGLE MTMHNLITPMFHQGMIVVGLPGNVPENALYGSYYGAGVTCPVDSDELMSEEGIQLGRA LGRRVSQVTGNLTAGQ*" /label="yhcB CDS" gene 928973..929503 /gene="yhcB" /locus_tag="BSU_09020" /old_locus_tag="BSU09020" /label="yhcB gene" CDS 929516..929890 /gene="yhcC" /locus_tag="BSU_09030" /old_locus_tag="BSU09030" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical membrane protein" /protein_id="NP_388784.1" /db_xref="EnsemblGenomes-Gn:BSU09030" /db_xref="EnsemblGenomes-Tr:CAB12731" /db_xref="GOA:P54587" /db_xref="SubtiList:BG11581" /db_xref="UniProtKB/Swiss-Prot:P54587" /translation="MAIIIAIIAAVIVIAALITFNVRNASPGPEKQEATDRIAPPEEE KNEAHYPAEARAAEHTPSVVKNDSPKEKRDTMGDDIYRQALQKFKHSDEVHAEEEVTE ESDKMQDRSYRDALLSMKNKKK*" /label="yhcC CDS" gene 929516..929890 /gene="yhcC" /locus_tag="BSU_09030" /old_locus_tag="BSU09030" /label="yhcC gene" downshifts 929879 /Source="Nicolas_upshifts" /id="D467" /incds=0 /nref=32 /ntot=145 /MaxReadThrough="1.78742" /MaxDrop="5.9171" /score="13.777309" /energy="-14.4" /TU="NA" /idTUdmin="U704" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 929890..930045 /gene="yhcD" /locus_tag="BSU_09040" /old_locus_tag="BSU09040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_388785.1" /db_xref="EnsemblGenomes-Gn:BSU09040" /db_xref="EnsemblGenomes-Tr:CAB12732" /db_xref="SubtiList:BG11582" /db_xref="UniProtKB/Swiss-Prot:P54588" /translation="MKKANPFTHAGLPFLLFPSIMFLSNKSMEYVVFHLDLVYYVTHT PRIFSGR*" /label="yhcD CDS" gene 929890..930045 /gene="yhcD" /locus_tag="BSU_09040" /old_locus_tag="BSU09040" /label="yhcD gene" promotor_-35 929980..929986 /Source="Nicolas_upshift_promotors" /id="U707" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.571428571428571" /psig=1 /xcortree=2541 /SigmaFactorBS="tgtttttatcaaataaatccatggaatatGTTGTATtccacc ttgatctaGTGTACTATGTTACTCATACaccgaggattttttccgggaggtaaagaca t" /listShort="yhcE, yhcF, yhcG, yhcH, yhcI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 930001..930020 /Source="Nicolas_upshift_promotors" /id="U707" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.571428571428571" /psig=1 /xcortree=2541 /SigmaFactorBS="tgtttttatcaaataaatccatggaatatGTTGTATtccacc ttgatctaGTGTACTATGTTACTCATACaccgaggattttttccgggaggtaaagaca t" /listShort="yhcE, yhcF, yhcG, yhcH, yhcI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 930011 /Source="Nicolas_upshifts" /id="U707" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.571428571428571" /psig=1 /xcortree=2541 /SigmaFactorBS="tgtttttatcaaataaatccatggaatatGTTGTATtccacc ttgatctaGTGTACTATGTTACTCATACaccgaggattttttccgggaggtaaagaca t" /listShort="yhcE, yhcF, yhcG, yhcH, yhcI" /GFF_Attribute="listLong" /label="upshifts" CDS 930050..930811 /gene="yhcE" /locus_tag="BSU_09050" /old_locus_tag="BSU09050" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane orphan protein" /protein_id="NP_388786.1" /db_xref="EnsemblGenomes-Gn:BSU09050" /db_xref="EnsemblGenomes-Tr:CAB12733" /db_xref="GOA:P54589" /db_xref="SubtiList:BG11583" /db_xref="UniProtKB/Swiss-Prot:P54589" /translation="MNSFLGLLKKDIKLSRMWLLVWICGIIFLLGTGHIIASRTKEPL VIFGFFVAVAFFLLFLSPVFVFYHLRKEGKSQLWLYNPNGGLWLFSSKLAASLLYQFV IQLALTAYGIWMYHMLSVKNLLEHQVDITSTVALLNMYGLISSLDMSVTVIVFWTVFH SLRNWRGMRWAAMVLLVAMWLFFDEYIISPLVESQKHFWPVTVYCNFDFHFHNVWRLE LKPIHLSVLGFPIAIVITFLLLIMASKLLDRKVEV*" /label="yhcE CDS" gene 930050..930811 /gene="yhcE" /locus_tag="BSU_09050" /old_locus_tag="BSU09050" /label="yhcE gene" promotor_-10 complement(930363..930381) /Source="Nicolas_upshift_promotors" /id="U708" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1187 /SigmaFactorBS="tatcaacttgatgctccagcagattttttacagagAGCATAt gatacatccatatgCCATAGGCTGTTAATGCCAactgaatcacaaattgatagagcaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(930377) /Source="Nicolas_upshifts" /id="U708" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1187 /SigmaFactorBS="tatcaacttgatgctccagcagattttttacagagAGCATAt gatacatccatatgCCATAGGCTGTTAATGCCAactgaatcacaaattgatagagcaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(930397..930402) /Source="Nicolas_upshift_promotors" /id="U708" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1187 /SigmaFactorBS="tatcaacttgatgctccagcagattttttacagagAGCATAt gatacatccatatgCCATAGGCTGTTAATGCCAactgaatcacaaattgatagagcaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 930814..931179 /gene="yhcF" /locus_tag="BSU_09060" /old_locus_tag="BSU09060" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (GntR family)" /protein_id="NP_388787.1" /db_xref="EnsemblGenomes-Gn:BSU09060" /db_xref="EnsemblGenomes-Tr:CAB12734" /db_xref="GOA:P54590" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11584" /db_xref="UniProtKB/Swiss-Prot:P54590" /translation="MDNQFQSSKPIYLQIADQIFYRLVRKELLPGDKLPSVREMAIQT KVNPNTIQRTYSEMERLGIVETRRGQGTFIAEKAEIVDELKDKLTREVLEGFVKQMKE LGLTKEEMLEGIKTFTEGG*" /label="yhcF CDS" gene 930814..931179 /gene="yhcF" /locus_tag="BSU_09060" /old_locus_tag="BSU09060" /label="yhcF gene" CDS 931181..931879 /gene="yhcG" /locus_tag="BSU_09070" /old_locus_tag="BSU09070" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15870467; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter ATP-binding protein" /protein_id="NP_388788.1" /db_xref="EnsemblGenomes-Gn:BSU09070" /db_xref="EnsemblGenomes-Tr:CAB12735" /db_xref="GOA:P54591" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11585" /db_xref="UniProtKB/Swiss-Prot:P54591" /translation="MEIKLEHVSKKYGRHTAVNDVSITLSSGRIYGLIGPNGSGKSTT LKMMAGLLFPTSGFVKVDEEQVTREMVRQTAYLTELDMFYPHFTVKDMVNFYQSQFPD FHTEQVYKLLNEMQLNPEKKIKKLSKGNRGRLKIVLALARRADVILLDEPFSGLDPMV RDSIVNSLVSYIDFEQQIVVIATHEIDEIETLLDEVIILANGEKVAQREVEDIREQEG MSVLQWFKSKMEVC*" /label="yhcG CDS" gene 931181..931879 /gene="yhcG" /locus_tag="BSU_09070" /old_locus_tag="BSU09070" /label="yhcG gene" CDS 931896..932813 /gene="yhcH" /locus_tag="BSU_09080" /old_locus_tag="BSU09080" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7476193, 15870467; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_388789.1" /db_xref="EnsemblGenomes-Gn:BSU09080" /db_xref="EnsemblGenomes-Tr:CAB12736" /db_xref="GOA:P54592" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11586" /db_xref="UniProtKB/Swiss-Prot:P54592" /translation="MKTVLELKNVTKNIRGRTIIDDLSFTIREGEVFGFLGPNGAGKT TTIRMMVGLMKLSKGDVLICGQSITKEYAKAIKHIGAIVENPELYKFLSGYKNLQQFA RMVKGVTKEKIDEVVELVGLTDRIHDKVKTYSLGMRQRLGLAQCLLHDPKVLILDEPT NGLDPAGIREIRDHLKKLTRERGMAVIVSSHLLSEMELMCDRIAILQKGKLIDIQNVK DENIDENDTYFFQVEQPSEAATVLNQYDLLSKTNGVEIKLAKEEVPAVIELLVMQQIR IYEVKVITKSLEDRFLEMTGETKEEVQHA*" /label="yhcH CDS" gene 931896..932813 /gene="yhcH" /locus_tag="BSU_09080" /old_locus_tag="BSU09080" /label="yhcH gene" CDS 932806..933747 /gene="yhcI" /locus_tag="BSU_09090" /old_locus_tag="BSU09090" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 15870467, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (permease)" /protein_id="NP_388790.1" /db_xref="EnsemblGenomes-Gn:BSU09090" /db_xref="EnsemblGenomes-Tr:CAB12737" /db_xref="GOA:P54593" /db_xref="InterPro:IPR032688" /db_xref="SubtiList:BG11587" /db_xref="UniProtKB/Swiss-Prot:P54593" /translation="MLNLIYNEWLKIFSRAGTWVMIGILGLTMVGFAFLANHFSAGES NSHWKQELQAQNAELKKEIKEDPSLKDGYKETITLNDYRIEHNIPSDTGYTVWSYVTD SANFTILTGLFTIIIAAGIVANEFNWGTIKLLMIRPLSRFQILMSKYITVLLFGLLLL LILFIGSTLLGLIFFGTGGETAANIHLIYKDGHVIEQNMMGHLATTYLSESVSALMVA TMAFMLSAVFRNSSLAVGFSIFLLVAGTTATAFIAAKFDWAKYILFANVDLTQYVDGT PLIKGMTMTFSLVMLAIYFIIFLLLAFGIFMKRDIAN*" /label="yhcI CDS" gene 932806..933747 /gene="yhcI" /locus_tag="BSU_09090" /old_locus_tag="BSU09090" /label="yhcI gene" downshifts 933729 /Source="Nicolas_upshifts" /id="D468" /incds=0 /nref=43 /ntot=186 /MaxReadThrough="2.67567" /MaxDrop="4.46232" /score="20.0218504" /energy="-13.6" /TU="NA" /idTUdmin="U707" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(933839..934042) /gene="cspB" /locus_tag="BSU_09100" /old_locus_tag="BSU09100" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12493834, 16352840, 22128343, 25851716" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12493834, 16352840, 22128343, 25851716; Product type f: factor" /codon_start=1 /transl_table=11 /product="major cold-shock protein, RNA helicase co-factor, RNA co-chaperone" /protein_id="NP_388791.1" /db_xref="EnsemblGenomes-Gn:BSU09100" /db_xref="EnsemblGenomes-Tr:CAB12738" /db_xref="GOA:P32081" /db_xref="InterPro:IPR002059" /db_xref="InterPro:IPR011129" /db_xref="InterPro:IPR012156" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR019844" /db_xref="PDB:1CSP" /db_xref="PDB:1CSQ" /db_xref="PDB:1NMF" /db_xref="PDB:1NMG" /db_xref="PDB:2ES2" /db_xref="PDB:2F52" /db_xref="PDB:2I5L" /db_xref="PDB:2I5M" /db_xref="PDB:3PF4" /db_xref="PDB:3PF5" /db_xref="SubtiList:BG10824" /db_xref="UniProtKB/Swiss-Prot:P32081" /translation="MLEGKVKWFNSEKGFGFIEVEGQDDVFVHFSAIQGEGFKTLEEG QAVSFEIVEGNRGPQAANVTKEA*" /label="cspB CDS" gene complement(933839..934042) /gene="cspB" /locus_tag="BSU_09100" /old_locus_tag="BSU09100" /label="cspB gene" downshifts complement(933853) /Source="Nicolas_upshifts" /id="D469" /incds=0 /nref=169 /ntot=281 /MaxReadThrough="5.28215" /MaxDrop="9.14889" /score="33.2405587" /energy="-13.1" /TU="U710" /idTUdmin="U710" /TUdmin="-48" /isTUend="FALSE" /label="downshifts" S_feature complement(934043..934170) /Source="Nicolas_S_feature" /locus_tag="new_984466_984593_c" /HighExp="BC, C90, GM 15, BI, T-1.10H, UNK1, S1, Sw, nit, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.999" /label="S315" misc_feature 934130..934141 /Source="Nicolas_upshift_promotors" /id="U709" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.618381618381618" /psig="0.098901098901099" /xcortree=713 /SigmaFactorBS="ttgctcttaacaaactttcaagacgaaaactcttacaaaact tTCTTCTTAAAGAtagttcgaacaaaaataattacctttactctaccagtaatcttca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 934147 /Source="Nicolas_upshifts" /id="U709" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.618381618381618" /psig="0.098901098901099" /xcortree=713 /SigmaFactorBS="ttgctcttaacaaactttcaagacgaaaactcttacaaaact tTCTTCTTAAAGAtagttcgaacaaaaataattacctttactctaccagtaatcttca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(934159..934178) /Source="Nicolas_upshift_promotors" /id="U710" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.32967032967033" /psig=1 /xcortree=2182 /SigmaFactorBS="tatggtattttccgaaaaaaatttcaataagcaGTTGTTttt tctgaagattACTGGTAGAGTAAAGGTAATtatttttgttcgaactatctttaagaag a" /listShort="S315, cspB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(934170) /Source="Nicolas_upshifts" /id="U710" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.32967032967033" /psig=1 /xcortree=2182 /SigmaFactorBS="tatggtattttccgaaaaaaatttcaataagcaGTTGTTttt tctgaagattACTGGTAGAGTAAAGGTAATtatttttgttcgaactatctttaagaag a" /listShort="S315, cspB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(934172..935310) /Source="Nicolas_S_feature" /locus_tag="new_984595_985733_c" /HighExp="C30, G180, G150, Oxctl, G135, Paraq, HPh, LPh, dia0, Lbexp" /AntisenseName="yhcJ" /AntisenseCor="0.25433958616302499" /AntisenseRegPval="-4.5999999999999996" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S316" promotor_-35 complement(934192..934197) /Source="Nicolas_upshift_promotors" /id="U710" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.32967032967033" /psig=1 /xcortree=2182 /SigmaFactorBS="tatggtattttccgaaaaaaatttcaataagcaGTTGTTttt tctgaagattACTGGTAGAGTAAAGGTAATtatttttgttcgaactatctttaagaag a" /listShort="S315, cspB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 934337..934344 /Source="Nicolas_upshift_promotors" /id="U711" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.386613386613387" /psig="0.997002997002997" /xcortree=1871 /SigmaFactorBS="attccttcattttgggaagataagtaataggAATTGACAacc ttattggatatGAGTAAGGTAAAAGTTAATcaatattacaaatgacaacgtttatcaa c" /listShort="S317, yhcJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 934359..934377 /Source="Nicolas_upshift_promotors" /id="U711" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.386613386613387" /psig="0.997002997002997" /xcortree=1871 /SigmaFactorBS="attccttcattttgggaagataagtaataggAATTGACAacc ttattggatatGAGTAAGGTAAAAGTTAATcaatattacaaatgacaacgtttatcaa c" /listShort="S317, yhcJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 934366 /Source="Nicolas_upshifts" /id="U711" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.386613386613387" /psig="0.997002997002997" /xcortree=1871 /SigmaFactorBS="attccttcattttgggaagataagtaataggAATTGACAacc ttattggatatGAGTAAGGTAAAAGTTAATcaatattacaaatgacaacgtttatcaa c" /listShort="S317, yhcJ" /GFF_Attribute="listLong" /label="upshifts" S_feature 934367..934477 /Source="Nicolas_S_feature" /locus_tag="new_984790_984900" /HighExp="Diami, dia15, dia5, H2O2, Salt, C90, Paraq, UNK1, T-4.40H, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S317" CDS 934478..935308 /gene="yhcJ" /locus_tag="BSU_09110" /old_locus_tag="BSU09110" /function="7: Transport and binding proteins" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative ABC transporter (binding lipoprotein)" /protein_id="NP_388792.2" /db_xref="EnsemblGenomes-Gn:BSU09110" /db_xref="EnsemblGenomes-Tr:CAB12739" /db_xref="GOA:P54594" /db_xref="InterPro:IPR004872" /db_xref="SubtiList:BG11588" /db_xref="UniProtKB/Swiss-Prot:P54594" /translation="MKKWLICSFVLVLLVSFTACSPSAEHESIKIGIAESDGAIWNYI AQKAEEAGLDIQLIPFSDYAESDIALANKEIDANAFQTISYFQSFTEKYKLNLAPLGT TYITPMGIYSKRYERIRDISRGAVVSVPDKAFDFGRALTVLQEAGLLTLKNGFNGTGS VDMIKDNPRHLKLKAVRQQDAVSGADVFVMKPSEAKKAGLNPKKHTLKSGGLMSEEEM NLIVVRAEDQDREALQTILELYQADDTAAFIEKEYQGDLVPAFLPLKRLSDWKNEFEH *" /label="yhcJ CDS" gene 934478..935308 /gene="yhcJ" /locus_tag="BSU_09110" /old_locus_tag="BSU09110" /label="yhcJ gene" downshifts 935267 /Source="Nicolas_upshifts" /id="D470" /incds=0 /nref=38 /ntot=203 /MaxReadThrough="2.83059" /MaxDrop="3.90173" /score="-4.94928928" /energy="-7.3" /TU="NA" /idTUdmin="U711" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" CDS complement(935311..936390) /gene="dgcK" /locus_tag="BSU_09120" /old_locus_tag="BSU09120" /EC_number="2.7.7.65" /function="16.3: Control" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:23893111" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23893111; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="diguanylate cyclase" /protein_id="NP_388793.1" /db_xref="EnsemblGenomes-Gn:BSU09120" /db_xref="EnsemblGenomes-Tr:CAB12740" /db_xref="GOA:P54595" /db_xref="InterPro:IPR000160" /db_xref="InterPro:IPR011620" /db_xref="InterPro:IPR029787" /db_xref="SubtiList:BG11589" /db_xref="UniProtKB/Swiss-Prot:P54595" /translation="MLKELFVNLTILITFNYLFTHLFKERLVHKKDSISFQAVKGLAC GLLGVILMVFGFTYQHSIIDLRNIPIMIAALYGGWVSTATALAMITAGRLLITMNTSA LYSVIIICIAAIPSLIVSRRKKVQLKHAFYLLIITNSLISFSFYFLIDLHSYELHLYF WIISIAGGMLSLYIIDHETNAHLLFKQYKFQAHFDFLTGVYNRRKFEETTKALYQQAA DTPHFQFALIYMDIDHFKTINDQYGHHEGDQVLKELGLRLKQTIRNTDPAARIGGEEF AVLLPNCSLDKAARIAERIRSTVSDAPIVLTNGDELSVTISLGAAHYPNNTEQPGSLP ILADQMLYKAKETGRNRVCFSEKKE*" /label="dgcK CDS" gene complement(935311..936390) /gene="dgcK" /locus_tag="BSU_09120" /old_locus_tag="BSU09120" /label="dgcK gene" promotor_-10 complement(936400..936419) /Source="Nicolas_upshift_promotors" /id="U712" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.988011988011988" /psig="0.999000999001" /xcortree=2608 /SigmaFactorBS="tatcaattcaagtaaaaaaaccttatataatgccttttttgt TCTTTtctttcccttccatcTTTAGTACCTTATATAAGGGtgataatatttgctgaaa g" /listShort="yhcK, S316" /listLong="S315, cspB" /label="promotor_-10" upshifts complement(936421) /Source="Nicolas_upshifts" /id="U712" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.988011988011988" /psig="0.999000999001" /xcortree=2608 /SigmaFactorBS="tatcaattcaagtaaaaaaaccttatataatgccttttttgt TCTTTtctttcccttccatcTTTAGTACCTTATATAAGGGtgataatatttgctgaaa g" /listShort="yhcK, S316" /listLong="S315, cspB" /label="upshifts" promotor_-35 complement(936435..936439) /Source="Nicolas_upshift_promotors" /id="U712" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.988011988011988" /psig="0.999000999001" /xcortree=2608 /SigmaFactorBS="tatcaattcaagtaaaaaaaccttatataatgccttttttgt TCTTTtctttcccttccatcTTTAGTACCTTATATAAGGGtgataatatttgctgaaa g" /listShort="yhcK, S316" /listLong="S315, cspB" /label="promotor_-35" promotor_-35 936497..936504 /Source="Nicolas_upshift_promotors" /id="U713" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.651348651348651" /psig=1 /xcortree=1745 /SigmaFactorBS="tttttacttgaattgataagttaaaataattcgCACTTGACc catcggaattagTGTAATATAGTAAATGAGAAaatttgaagggagagtttacctgctt t" /listShort="tcyP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 936518..936537 /Source="Nicolas_upshift_promotors" /id="U713" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.651348651348651" /psig=1 /xcortree=1745 /SigmaFactorBS="tttttacttgaattgataagttaaaataattcgCACTTGACc catcggaattagTGTAATATAGTAAATGAGAAaatttgaagggagagtttacctgctt t" /listShort="tcyP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 936524 /Source="Nicolas_upshifts" /id="U713" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.651348651348651" /psig=1 /xcortree=1745 /SigmaFactorBS="tttttacttgaattgataagttaaaataattcgCACTTGACc catcggaattagTGTAATATAGTAAATGAGAAaatttgaagggagagtttacctgctt t" /listShort="tcyP" /GFF_Attribute="listLong" /label="upshifts" CDS 936563..937954 /gene="tcyP" /locus_tag="BSU_09130" /old_locus_tag="BSU09130" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12193636, 15262924, 15849754, 16513748, 16850406, 19508281" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12193636, 15262924, 15849754, 16513748, 16850406, 19508281; Product type t : transporter" /codon_start=1 /transl_table=11 /product="(sodium)-cystine symporter" /protein_id="NP_388794.1" /db_xref="EnsemblGenomes-Gn:BSU09130" /db_xref="EnsemblGenomes-Tr:CAB12741" /db_xref="GOA:P54596" /db_xref="InterPro:IPR001991" /db_xref="InterPro:IPR036458" /db_xref="SubtiList:BG11590" /db_xref="UniProtKB/Swiss-Prot:P54596" /translation="METLLVVLHVFILFLLILGLFVMQKKHVSFSKRVFTALGLGIVF GFALQLIYGPTSNIVIQTADWFNIAGGGYVKLLQMVVMPLVFISILGAFTKLKLTKNL GKISGLIIGILVATTAVAAAVGIASALSFDLQAIQVDQGSTELSRGQELQQKSEDMTA KTLPQQIVELLPGNPFLDFTGARPTSTIAVVIFAAFLGVAFLGVKHKQPEQAETFKKL VDAVYAIVMRVVTLILRLTPYGVLAIMTKTIATSDLDSILKLGMFVIASYAALITMFI IHLLLLTFSGLNPVIYLKKAVPVLVFAFTSRSSAGALPLNIKTQRSMGVPEGIANFAG SFGLSIGQNGCAGIYPAMLAMMIAPTVGQNPFDPVFIITVIAVVAISSFGVAGVGGGA TFAALLVLSSLNMPVALAGLLISIEPLIDMGRTALNVSGSMTSGLITSKVTKEIDQGA FHDQSRVIEAEEA*" /label="tcyP CDS" gene 936563..937954 /gene="tcyP" /locus_tag="BSU_09130" /old_locus_tag="BSU09130" /label="tcyP gene" S_feature complement(937590..937993) /Source="Nicolas_S_feature" /locus_tag="new_988013_988416_c" /HighExp="S8, S6, Etha, S5, S7, S4, ferm, nit, Salt, S3" /AntisenseName="tcyP" /AntisenseCor="-0.40132140065468203" /AntisenseRegPval="-11.1" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.96" /TUlongSig="NA" /TUlongPSig="NA" /label="S318" downshifts 937933 /Source="Nicolas_upshifts" /id="D471" /incds=0 /nref=58 /ntot=164 /MaxReadThrough="2.37899" /MaxDrop="5.34563" /score="19.9118074" /energy="-12.8" /TU="NA" /idTUdmin="U713" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" CDS complement(937994..938449) /gene="yhcM" /locus_tag="BSU_09140" /old_locus_tag="BSU09140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 21625606" /codon_start=1 /transl_table=11 /product="expressed protein of unknown function" /protein_id="NP_388795.1" /db_xref="EnsemblGenomes-Gn:BSU09140" /db_xref="EnsemblGenomes-Tr:CAB12742" /db_xref="SubtiList:BG11591" /db_xref="UniProtKB/Swiss-Prot:P54597" /translation="MLFNQRRGISPAALIIGSTMLITALSPQIRQRISGFITGQMNRR NSENNTFDASNVGNMVKQAFSGSSGSSGDNQDRSQHQSQRQNGRQHQHAGQQQPQHQH TQSQTRQTETAAKKRQPHYAEPIHFEQNAMNVMDDNTMMEMLEDLEPGR*" /label="yhcM CDS" gene complement(937994..938449) /gene="yhcM" /locus_tag="BSU_09140" /old_locus_tag="BSU09140" /label="yhcM gene" promotor_-10 complement(938464..938482) /Source="Nicolas_upshift_promotors" /id="U714" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=733 /SigmaFactorBS="tttaattatgcatgcaaatctggaggaaatgctttcccggga aatataaCGGTTAAtttgtctaacgaggGGGAAAATATGAATACACTgcaaaggaggg a" /listShort="yhcM, S318" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(938492) /Source="Nicolas_upshifts" /id="U714" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=733 /SigmaFactorBS="tttaattatgcatgcaaatctggaggaaatgctttcccggga aatataaCGGTTAAtttgtctaacgaggGGGAAAATATGAATACACTgcaaaggaggg a" /listShort="yhcM, S318" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(938497..938503) /Source="Nicolas_upshift_promotors" /id="U714" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=733 /SigmaFactorBS="tttaattatgcatgcaaatctggaggaaatgctttcccggga aatataaCGGTTAAtttgtctaacgaggGGGAAAATATGAATACACTgcaaaggaggg a" /listShort="yhcM, S318" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 938541..938547 /Source="Nicolas_upshift_promotors" /id="U715" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=835 /SigmaFactorBS="tatatttcccgggaaagcatttcctccagatttgcaTGCATA AttaaagccagttaGAAAAACCTATAagtaaagtgataaaggaggaattcacatgttt g" /listShort="yhcN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 938561..938572 /Source="Nicolas_upshift_promotors" /id="U715" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=835 /SigmaFactorBS="tatatttcccgggaaagcatttcctccagatttgcaTGCATA AttaaagccagttaGAAAAACCTATAagtaaagtgataaaggaggaattcacatgttt g" /listShort="yhcN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 938565 /Source="Nicolas_upshifts" /id="U715" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=835 /SigmaFactorBS="tatatttcccgggaaagcatttcctccagatttgcaTGCATA AttaaagccagttaGAAAAACCTATAagtaaagtgataaaggaggaattcacatgttt g" /listShort="yhcN" /GFF_Attribute="listLong" /label="upshifts" CDS 938599..939168 /gene="yhcN" /locus_tag="BSU_09150" /old_locus_tag="BSU09150" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9611260, 28333204; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative germination lipoprotein" /protein_id="NP_388796.2" /db_xref="EnsemblGenomes-Gn:BSU09150" /db_xref="EnsemblGenomes-Tr:CAB12743" /db_xref="GOA:P54598" /db_xref="InterPro:IPR014247" /db_xref="InterPro:IPR019076" /db_xref="SubtiList:BG11592" /db_xref="UniProtKB/Swiss-Prot:P54598" /translation="MFGKKQVLASVLLIPLLMTGCGVADQGEGRRDNNDVRNVNYRNP ANDDMRNVNNRDNVDNNVNDNVNNNRVNDDNNNDRKLEVADEAADKVTDLKEVKHADI IVAGNQAYVAVVLTNGNKGAVENNLKKKIAKKVRSTDKNIDNVYVSANPDFVERMQGY GKRIQNGDPIAGLFDEFTQTVQRVFPNAE*" /label="yhcN CDS" gene 938599..939168 /gene="yhcN" /locus_tag="BSU_09150" /old_locus_tag="BSU09150" /label="yhcN gene" promotor_-35 938795..938801 /Source="Nicolas_upshift_promotors" /id="U716" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.634365634365634" /psig="0.634365634365634" /xcortree=783 /SigmaFactorBS="gtaaacaatcgggataacgttgacaacaatgttaatgataat gTCAATAAcaatcgtgtaaatGACGATAATAACaacgaccgaaaacttgaggttgctg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 938812 /Source="Nicolas_upshifts" /id="U716" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.634365634365634" /psig="0.634365634365634" /xcortree=783 /SigmaFactorBS="gtaaacaatcgggataacgttgacaacaatgttaatgataat gTCAATAAcaatcgtgtaaatGACGATAATAACaacgaccgaaaacttgaggttgctg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 938815..938826 /Source="Nicolas_upshift_promotors" /id="U716" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.634365634365634" /psig="0.634365634365634" /xcortree=783 /SigmaFactorBS="gtaaacaatcgggataacgttgacaacaatgttaatgataat gTCAATAAcaatcgtgtaaatGACGATAATAACaacgaccgaaaacttgaggttgctg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 939143 /Source="Nicolas_upshifts" /id="D472" /incds=0 /nref=26 /ntot=183 /MaxReadThrough="1.84697" /MaxDrop="7.80159" /score="33.0647397" /energy="-12.9" /TU="NA" /idTUdmin="U715" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" promotor_-35 939211..939220 /Source="Nicolas_upshift_promotors" /id="U717" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1355 /SigmaFactorBS="caatttgtgcggctttttctttgcgttAATGACACACtgcga actcaggcTGCATAGAGTAAAAATAAAAaggtacaagacggaccggctcagggaggga g" /listShort="yhcO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 939234..939253 /Source="Nicolas_upshift_promotors" /id="U717" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1355 /SigmaFactorBS="caatttgtgcggctttttctttgcgttAATGACACACtgcga actcaggcTGCATAGAGTAAAAATAAAAaggtacaagacggaccggctcagggaggga g" /listShort="yhcO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 939244 /Source="Nicolas_upshifts" /id="U717" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1355 /SigmaFactorBS="caatttgtgcggctttttctttgcgttAATGACACACtgcga actcaggcTGCATAGAGTAAAAATAAAAaggtacaagacggaccggctcagggaggga g" /listShort="yhcO" /GFF_Attribute="listLong" /label="upshifts" CDS 939289..940257 /gene="yhcO" /locus_tag="BSU_09165" /old_locus_tag="BSU09165" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="putative exported protein (sporulation germination island)" /protein_id="NP_388797.2" /db_xref="EnsemblGenomes-Gn:BSU09165" /db_xref="EnsemblGenomes-Tr:CAB12744" /db_xref="SubtiList:BG11593" /db_xref="UniProtKB/Swiss-Prot:P54599" /translation="MRDGIGKRAASALFLCGVLVMLAVSSAIVSSAMYILSFPGQASG ITKEQVTKHMKKESFKQADIYYTSKEKSLLPLTKETLEYAVSINQIMIGYSNQKPIDI IFFPNEKQMEAYSGLLDVVGFYSEREQLIGLLPEEKKKLLEGDEVAVYLYQRLLIHEY SHHAFHQKLKELETDPDEFPLWFHEGLSEWIANYELLIDPITFSVVPFDRLQTDRDWQ EARAEYDTDVYLQSFYMIDELTDKYGKDIISEMIKETAKKGDFEKGFKSATKESLDQF EKDFKKKFEKNSAALDSIYPMPLLLVKSLLTHSALCRRHLSLGRGE*" /label="yhcO CDS" gene 939289..940257 /gene="yhcO" /locus_tag="BSU_09165" /old_locus_tag="BSU09165" /label="yhcO gene" downshifts 940133 /Source="Nicolas_upshifts" /id="D473" /incds=1 /nref=28 /ntot=62 /MaxReadThrough="1.51621" /MaxDrop="5.75619" /score="6.21571271" /energy="-16.1" /TU="NA" /idTUdmin="U717" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(940189..940842) /gene="yhcQ" /locus_tag="BSU_09180" /old_locus_tag="BSU09180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="NP_388799.1" /db_xref="EnsemblGenomes-Gn:BSU09180" /db_xref="EnsemblGenomes-Tr:CAB12746" /db_xref="GOA:P54601" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR012851" /db_xref="SubtiList:BG11595" /db_xref="UniProtKB/Swiss-Prot:P54601" /translation="MDQFNQQQQSQMNKGIPGKPHKNHGGHEMFDMHEVLSGTLTVLD QFMMLRQFCKDQELLNILDRQHQFITSQYNITAECFKTGSEPSQKTATYMMKEDNQTV YGMQPSQPKKPVQSMNDIDDSIISRQMLCAIKAQASMLTMASLEMTNPAVRRVLSAQI QEYVEMAFEIFLYQNKHGYYQVPQLDAQDMEQLRNSFAPAQGQMPPTQGGMGQQGLH* " /label="yhcQ CDS" gene complement(940189..940842) /gene="yhcQ" /locus_tag="BSU_09180" /old_locus_tag="BSU09180" /label="yhcQ gene" downshifts complement(940206) /Source="Nicolas_upshifts" /id="D474" /incds=0 /nref=15 /ntot=57 /MaxReadThrough="4.13099" /MaxDrop="4.95733" /score="8.67086892" /energy="-12.9" /TU="U718" /idTUdmin="U718" /TUdmin="-546" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(940873..940884) /Source="Nicolas_upshift_promotors" /id="U718" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=828 /SigmaFactorBS="acagacagcatataattcctttcaggcttcTGCATAAtacac ggcagactgACACAAAATACAgctgatctgaaaaaaaaggaggaattcggtttggatc a" /listShort="yhcQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(940875) /Source="Nicolas_upshifts" /id="U718" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=828 /SigmaFactorBS="acagacagcatataattcctttcaggcttcTGCATAAtacac ggcagactgACACAAAATACAgctgatctgaaaaaaaaggaggaattcggtttggatc a" /listShort="yhcQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(940899..940905) /Source="Nicolas_upshift_promotors" /id="U718" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=828 /SigmaFactorBS="acagacagcatataattcctttcaggcttcTGCATAAtacac ggcagactgACACAAAATACAgctgatctgaaaaaaaaggaggaattcggtttggatc a" /listShort="yhcQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 940914..940922 /Source="Nicolas_upshift_promotors" /id="U719" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=543 /SigmaFactorBS="tctgccgtgtattatgcagaagcctgAAAGGAATTatatgct gtcTGTCGAAATGATAAGCAGAcaaaatcgttgtcattatgtgtataagggaggaaat a" /listShort="yhcR, yhcS" /GFF_Attribute="listLong" /label="promotor_-35" CDS 940925..944578 /gene="mncR" /locus_tag="BSU_09190" /old_locus_tag="BSU09190" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:15292138, 21800427, 22020651" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15292138, 21800427, 22020651; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="non specific extracellular Ca2+-dependent endonuclease cleaving RNA and DNA" /protein_id="NP_388800.1" /db_xref="EnsemblGenomes-Gn:BSU09190" /db_xref="EnsemblGenomes-Tr:CAB12747" /db_xref="GOA:P54602" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR006146" /db_xref="InterPro:IPR006179" /db_xref="InterPro:IPR008334" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR016071" /db_xref="InterPro:IPR019948" /db_xref="InterPro:IPR029052" /db_xref="InterPro:IPR035437" /db_xref="InterPro:IPR035451" /db_xref="InterPro:IPR036907" /db_xref="SubtiList:BG11596" /db_xref="UniProtKB/Swiss-Prot:P54602" /translation="MLSVEMISRQNRCHYVYKGGNMMRRILHIVLITALMFLNVMYTF EAVKAAEPQQPISIEKAIQQKEGQALVEGYAVGQAVSPQHYKLTSPFSNDYNVALADR KNKTSPEHILPVQIPSAFRSQFGLQTNPLLLGKKITVQGKLENYFNTTGLKNVQSMNV TDDTKTPPAEQQVTINEARGRLNEEVTIKGIITADQNAIGGGKLSTFLQDETGGINIY SPSPEQFPELKEGMDVTVTGKITSYQGLKEIVPNSSGIKINQSNQSLPAPKHLTINEL INGSLGDQYEGRLVKLTAFVSSIPSSPAGGGYNVTMIDDDHHAMTLRVMNETGVINEL DEGKWYEFTGVLSRYQTFQLLPRKSADLKLLEEQPAPPSAEGEYEGIVDRVVDGDTIH LKSPVLGTTKIRFVNVDAPETYHTPKNDADENQLRFGKKASDYLKTVLSPGDKITVKV GSEAKDSYGRLLGQVITESGSNVNLELVKNGYAPTYFIWPVDNEEDYQQFQAAVAAAK KDQKGIWNENDPLMEMPFEFRAREQGKGLTRYVGDSSNKTYVQPADWKKIAVENRIFF ASASEAESAGYKKRQTAPQEHVPLRILSMNDLHGKIDQQYELDLDGNGTVDGTFGRMD YAAAYLKEKKAEKKNSLIVHAGDMIGGSSPVSSLLQDEPTVELMEDIGFDVGTVGNHE FDEGTDELLRILNGGDHPKGTSGYDGQNFPLVCANCKMKSTGEPFLPAYDIINVEGVP VAFIGVVTQSAAGMVMPEGIKNIEFTDEATAVNKAAEELKKKGVKAIAVLAHMSAEQN GNAITGESADLANKTDSEIDVIFAAHNHQVVNGEVNGKLIVQAFEYGKAIGVVDVEID KTTKDIVKKSAEIVYVDQSKIEPDVSASAILKKYETIAEPIISEVVGEAAVDMEGGYS NDGDTPLGNLIADGMRAAMKTDFALMNGGGIREALKKGPITWGDLYNIQPFGNVLTKL EIKGKDLREIINAQISPVFGPDYSISGFTYTWDKETGKAVDMKMADGTEIQPDATYTL TVNNFMATATGAKYQPIGLLGKNPVTGPEDLEATVEYVKSFDEPIAYTKEGRIKLAEA SDIEDPVTEDPITEEPGDDPGTEDPIKEDPRPGEDLPDIKETPGTAPVHQLPPSAISR FNEIPINNTKTADTANSISTLPLQTETAESGSDHQLPDTSAGYYNFMVIGAAVTLSGT YLYVRRKRSASRT*" /label="mncR CDS" gene 940925..944578 /gene="mncR" /locus_tag="BSU_09190" /old_locus_tag="BSU09190" /label="mncR gene" promotor_-10 940933..940951 /Source="Nicolas_upshift_promotors" /id="U719" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=543 /SigmaFactorBS="tctgccgtgtattatgcagaagcctgAAAGGAATTatatgct gtcTGTCGAAATGATAAGCAGAcaaaatcgttgtcattatgtgtataagggaggaaat a" /listShort="yhcR, yhcS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 940948 /Source="Nicolas_upshifts" /id="U719" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=543 /SigmaFactorBS="tctgccgtgtattatgcagaagcctgAAAGGAATTatatgct gtcTGTCGAAATGATAAGCAGAcaaaatcgttgtcattatgtgtataagggaggaaat a" /listShort="yhcR, yhcS" /GFF_Attribute="listLong" /label="upshifts" CDS 944575..945171 /gene="srtA" /locus_tag="BSU_09200" /old_locus_tag="BSU09200" /EC_number="3.4.22.70" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12823805, 21800427, 22020651, 25038633" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12823805, 21800427, 22020651, 25038633; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sortase A" /protein_id="NP_388801.1" /db_xref="EnsemblGenomes-Gn:BSU09200" /db_xref="EnsemblGenomes-Tr:CAB12748" /db_xref="GOA:P54603" /db_xref="InterPro:IPR005754" /db_xref="InterPro:IPR023365" /db_xref="SubtiList:BG11597" /db_xref="UniProtKB/Swiss-Prot:P54603" /translation="MKKVIPLFIIAAGLVIAGYGGFKLIDTNTKTEQTLKEAKLAAKK PQEASGTKNSTDQAKNKASFKPETGQASGILEIPKINAELPIVEGTDADDLEKGVGHY KDSYYPDENGQIVLSGHRDTVFRRTGELEKGDQLRLLLSYGEFTYEIVKTKIVDKDDT SIITLQHEKEELILTTCYPFSYVGNAPKRYIIYGKRVT*" /label="srtA CDS" gene 944575..945171 /gene="srtA" /locus_tag="BSU_09200" /old_locus_tag="BSU09200" /label="srtA gene" downshifts 945150 /Source="Nicolas_upshifts" /id="D475" /incds=0 /nref=142 /ntot=248 /MaxReadThrough="0.9984" /MaxDrop="5.92245" /score="-4.06268332" /energy="-8.8" /TU="NA" /idTUdmin="U719" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(945201..946109) /gene="yhcT" /locus_tag="BSU_09210" /old_locus_tag="BSU09210" /EC_number="5.4.99.-" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9814761, 15044829; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA pseudouridine synthase" /protein_id="NP_388802.2" /db_xref="EnsemblGenomes-Gn:BSU09210" /db_xref="EnsemblGenomes-Tr:CAB12749" /db_xref="GOA:P54604" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR006145" /db_xref="InterPro:IPR006224" /db_xref="InterPro:IPR006225" /db_xref="InterPro:IPR020103" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG11598" /db_xref="UniProtKB/Swiss-Prot:P54604" /translation="MNQKGRGLEILINEKQDGQWLFSVLKTALKASKPVIQDWMSHQQ IKVNHESVLNNMIVKKGDRVFIDLQESEASSVIPEYGELDILFEDNHMLIINKPAGIA THPNEDGQTGTLANLIAYHYQINGETCKVRHVHRLDQDTSGAIVFAKHRLAHAILDQQ LEKKTLKRTYTAIAEGKLRTKKGTINSPIGRDRSHPTRRRVSPGGQTAVTHFKVMASN AKERLSLVELELETGRTHQIRVHLASLGHPLTGDSLYGGGSKLLNRQALHANKVQAVH PITDELIVAEAPFPADMKNLCRTYFS*" /label="yhcT CDS" gene complement(945201..946109) /gene="yhcT" /locus_tag="BSU_09210" /old_locus_tag="BSU09210" /label="yhcT gene" promotor_-35 946165..946173 /Source="Nicolas_upshift_promotors" /id="U721" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig="0.999000999001" /xcortree=2026 /SigmaFactorBS="tttcgaagcggaaggctgctgtttctcataggaaacacttaC CTTAGCTTtcgcgtttttttcTGTGCTATTCTTGAGTAAGActtaggatattcgatgg c" /listShort="yhcU" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(946166..946177) /Source="Nicolas_upshift_promotors" /id="U720" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=803 /SigmaFactorBS="cctttcttgccatcgaatatcctaagtcttactcaAGAATAG cacagaaaaaaacGCGAAAGCTAAGgtaagtgtttcctatgagaaacagcagccttcc g" /listShort="yhcT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(946172) /Source="Nicolas_upshifts" /id="U720" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=803 /SigmaFactorBS="cctttcttgccatcgaatatcctaagtcttactcaAGAATAG cacagaaaaaaacGCGAAAGCTAAGgtaagtgtttcctatgagaaacagcagccttcc g" /listShort="yhcT" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(946174..946660) /Source="Nicolas_S_feature" /locus_tag="new_996597_997083_c" /HighExp="S8, dia15, Diami, H2O2, G180, G150, dia5, Paraq, Oxctl, S7" /AntisenseName="yhcU" /AntisenseCor="0.69394173601478304" /AntisenseRegPval="-39.200000000000003" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.958" /TUlongSig="NA" /TUlongPSig="NA" /label="S319" upshifts 946184 /Source="Nicolas_upshifts" /id="U721" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig="0.999000999001" /xcortree=2026 /SigmaFactorBS="tttcgaagcggaaggctgctgtttctcataggaaacacttaC CTTAGCTTtcgcgtttttttcTGTGCTATTCTTGAGTAAGActtaggatattcgatgg c" /listShort="yhcU" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 946187..946206 /Source="Nicolas_upshift_promotors" /id="U721" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig="0.999000999001" /xcortree=2026 /SigmaFactorBS="tttcgaagcggaaggctgctgtttctcataggaaacacttaC CTTAGCTTtcgcgtttttttcTGTGCTATTCTTGAGTAAGActtaggatattcgatgg c" /listShort="yhcU" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(946191..946197) /Source="Nicolas_upshift_promotors" /id="U720" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=803 /SigmaFactorBS="cctttcttgccatcgaatatcctaagtcttactcaAGAATAG cacagaaaaaaacGCGAAAGCTAAGgtaagtgtttcctatgagaaacagcagccttcc g" /listShort="yhcT" /GFF_Attribute="listLong" /label="promotor_-35" CDS 946220..946615 /gene="yhcU" /locus_tag="BSU_09220" /old_locus_tag="BSU09220" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388803.2" /db_xref="EnsemblGenomes-Gn:BSU09220" /db_xref="EnsemblGenomes-Tr:CAB12750" /db_xref="InterPro:IPR020355" /db_xref="SubtiList:BG11599" /db_xref="UniProtKB/Swiss-Prot:P54605" /translation="MARKVIDVRIVNAATAEQESFIKELSMELIHDVFPLYFSELDIQ RFKKKGVLSLNNHYYQGTLKEAFQIMACLQMIHIILTKPSPHSDLSDQAIFEKNSKML NDFGIYFPFAFSDFQKKTNKAFFGQRRLI*" /label="yhcU CDS" gene 946220..946615 /gene="yhcU" /locus_tag="BSU_09220" /old_locus_tag="BSU09220" /label="yhcU gene" misc_feature complement(946646..946665) /Source="Nicolas_upshift_promotors" /id="U722" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.709290709290709" /psig="0.958041958041958" /xcortree=1819 /SigmaFactorBS="cagacacgagccgtttaaaaagggagttagaggaaaggtttt atgatatgatttcTCTGATACAAAAAGAGCTTTtctaaaaatagaaaagcccttgccg c" /listShort="S319, yhcT" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(946660) /Source="Nicolas_upshifts" /id="U722" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.709290709290709" /psig="0.958041958041958" /xcortree=1819 /SigmaFactorBS="cagacacgagccgtttaaaaagggagttagaggaaaggtttt atgatatgatttcTCTGATACAAAAAGAGCTTTtctaaaaatagaaaagcccttgccg c" /listShort="S319, yhcT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 946700..946706 /Source="Nicolas_upshift_promotors" /id="U723" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=842 /SigmaFactorBS="tttgtatcagagaaatcatatcataaaacctttcctctaact cccTTTTTAAacggctcgtgtctGAACATACTAATgattgaaaggggtgctgacaatg a" /listShort="yhcV" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 946715 /Source="Nicolas_upshifts" /id="U723" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=842 /SigmaFactorBS="tttgtatcagagaaatcatatcataaaacctttcctctaact cccTTTTTAAacggctcgtgtctGAACATACTAATgattgaaaggggtgctgacaatg a" /listShort="yhcV" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 946720..946731 /Source="Nicolas_upshift_promotors" /id="U723" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=842 /SigmaFactorBS="tttgtatcagagaaatcatatcataaaacctttcctctaact cccTTTTTAAacggctcgtgtctGAACATACTAATgattgaaaggggtgctgacaatg a" /listShort="yhcV" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(946730..946744) /Source="Nicolas_upshift_promotors" /id="U724" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.99000999000999" /psig="0.002997002997003" /xcortree=708 /SigmaFactorBS="ttcggagaaacggttgccacctgcgttgtcattgtatcttta actgaaCTCATtgtcagcACCCCTTTCAATCATtagtatgttcagacacgagccgttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(946744) /Source="Nicolas_upshifts" /id="U724" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.99000999000999" /psig="0.002997002997003" /xcortree=708 /SigmaFactorBS="ttcggagaaacggttgccacctgcgttgtcattgtatcttta actgaaCTCATtgtcagcACCCCTTTCAATCATtagtatgttcagacacgagccgttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(946752..946756) /Source="Nicolas_upshift_promotors" /id="U724" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.99000999000999" /psig="0.002997002997003" /xcortree=708 /SigmaFactorBS="ttcggagaaacggttgccacctgcgttgtcattgtatcttta actgaaCTCATtgtcagcACCCCTTTCAATCATtagtatgttcagacacgagccgttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 946752..947174 /gene="yhcV" /locus_tag="BSU_09230" /old_locus_tag="BSU09230" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17322312; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative CBS containing enzyme (sporulation-/ germination-related)" /protein_id="NP_388804.1" /db_xref="EnsemblGenomes-Gn:BSU09230" /db_xref="EnsemblGenomes-Tr:CAB12751" /db_xref="InterPro:IPR000644" /db_xref="SubtiList:BG11600" /db_xref="UniProtKB/Swiss-Prot:P54606" /translation="MSSVKDTMTTQVATVSPNQTIQEAASLMKQHNVGAIPVVEQGVL KGMLTDRDIALRTTAQGRDGQTPVSEVMSTELVSGNPNMSLEDASQLMAQHQIRRLPI VDQNNLVGIVALGDLAVNQMSNESAGSALTNISHQNIH*" /label="yhcV CDS" gene 946752..947174 /gene="yhcV" /locus_tag="BSU_09230" /old_locus_tag="BSU09230" /label="yhcV gene" promotor_no_box complement(947078..947178) /Source="Nicolas_upshift_promotors" /id="U725" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.3996003996004" /psig="0.014985014985015" /xcortree=1493 /SigmaFactorBS="cttattaatgaatgttttggtgagaaatgtttgtcagcgctg atcccgcagactcgttcgacatctgattgactgccaggtctccaagcgcaacgatccc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(947118) /Source="Nicolas_upshifts" /id="U725" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.3996003996004" /psig="0.014985014985015" /xcortree=1493 /SigmaFactorBS="cttattaatgaatgttttggtgagaaatgtttgtcagcgctg atcccgcagactcgttcgacatctgattgactgccaggtctccaagcgcaacgatccc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 947152 /Source="Nicolas_upshifts" /id="D476" /incds=0 /nref=50 /ntot=61 /MaxReadThrough="2.62549" /MaxDrop="7.03747" /score="-2.59023198" /energy="-12.1" /TU="NA" /idTUdmin="U723" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(947184) /Source="Nicolas_upshifts" /id="D477" /incds=0 /nref=2 /ntot=10 /MaxReadThrough="0.0992700000000006" /MaxDrop="3.96142" /score="-9.32793172" /energy="-9.1" /TU="NA" /idTUdmin="U724" /TUdmin="-506" /isTUend="FALSE" /label="downshifts" promotor_-35 947224..947231 /Source="Nicolas_upshift_promotors" /id="U726" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=1997 /SigmaFactorBS="gtgcaggctctttcttcacataaaaccttacTTTTTGAAagc agacttgtttCGGGGTATAGTGAGTGTATAcatatgtctcaattcgtactaaaggagt t" /listShort="yhcW, yhcX, yhzG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 947245..947264 /Source="Nicolas_upshift_promotors" /id="U726" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=1997 /SigmaFactorBS="gtgcaggctctttcttcacataaaaccttacTTTTTGAAagc agacttgtttCGGGGTATAGTGAGTGTATAcatatgtctcaattcgtactaaaggagt t" /listShort="yhcW, yhcX, yhzG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 947253 /Source="Nicolas_upshifts" /id="U726" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=1997 /SigmaFactorBS="gtgcaggctctttcttcacataaaaccttacTTTTTGAAagc agacttgtttCGGGGTATAGTGAGTGTATAcatatgtctcaattcgtactaaaggagt t" /listShort="yhcW, yhcX, yhzG" /GFF_Attribute="listLong" /label="upshifts" CDS 947301..947963 /gene="glpW" /locus_tag="BSU_09240" /old_locus_tag="BSU09240" /EC_number="3.1.3.18" /EC_number="3.1.3.68" /EC_number="3.1.3.-" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16990279, 22353596; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous phosphoglycolate phosphatase / glycerol-3-phosphate phosphatase / 2-deoxyglucose-6-phosphatase" /protein_id="NP_388805.1" /db_xref="EnsemblGenomes-Gn:BSU09240" /db_xref="EnsemblGenomes-Tr:CAB12752" /db_xref="GOA:P54607" /db_xref="InterPro:IPR006439" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG11601" /db_xref="UniProtKB/Swiss-Prot:P54607" /translation="MIKALIFDFDGLILDTETHEYEVLQEIFEEHGSVLPLSVWGKVI GTAAGFRPFEYLEEQIGKKLNHEELTQLRRERFAKRMESEKARPGVEAYLNAAKDLGL KIGLASSSDYKWVSGHLKQIGLFDDFEVIQTADDVEEVKPNPELYLLAAKNLGVSPAE CLAFEDSVNGSIAAKRAGMKCVIVPNKVTGTLMFEDYDHRLESMAEMELALLLDHLNS QN*" /label="glpW CDS" gene 947301..947963 /gene="glpW" /locus_tag="BSU_09240" /old_locus_tag="BSU09240" /label="glpW gene" CDS 947979..949520 /gene="yhcX" /locus_tag="BSU_09250" /old_locus_tag="BSU09250" /EC_number="3.5.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 26337367, 26808445, 17555270; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative amidohydrolase" /protein_id="NP_388806.2" /db_xref="EnsemblGenomes-Gn:BSU09250" /db_xref="EnsemblGenomes-Tr:CAB12753" /db_xref="GOA:P54608" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR001110" /db_xref="InterPro:IPR003010" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR036526" /db_xref="SubtiList:BG11602" /db_xref="UniProtKB/Swiss-Prot:P54608" /translation="MSEKLDLTRFEKKMVIRNIEEKDIDKIIDLQKDCFPGMEPWKRE HLISHLEHFPEGQFCAEFEGEIIGSCSSLLINFDEYDDRHTWQDITDDGYITNHNPDG LNMYGIEVMVHPKYRRMKIGHRLYEARKDLARRLNLKSIIIGGRIPNYHKYAEEMTAR EYVEQVTRHQIYDPVLSFQLMNGFTLMRINPNYLPDDTASIKYATLMEWNNVDYLPQQ TKRYYKSAFPVRICVIQYEMKKIYSFEEFANQVEYYVDVASDARSDFAVFPEIFTTQL MSFLEERSPSLAVQRITEYTEDYISLFTDLAVKYNVNIIGGSHFVEEEGKIYNIAYLF RRDGTIEKQYKLHITPNERKWWGISAGDQVRVFDTDCGKIAIQICYDIEFPELARIAA DKGAKIIFTPFCTEDRQGYLRVRYCSQARAVENQIYTVISGTVGNLPQTENMDIQYAQ SGIFAPSDFEFARDGIVGETNPNIEMVVIGDVDLEILRRQRQNGTVRQLKDRRRDIYH IQYKK*" /label="yhcX CDS" gene 947979..949520 /gene="yhcX" /locus_tag="BSU_09250" /old_locus_tag="BSU09250" /label="yhcX gene" downshifts 949503 /Source="Nicolas_upshifts" /id="D478" /incds=0 /nref=57 /ntot=238 /MaxReadThrough="4.24486" /MaxDrop="5.06754" /score="24.7413026" /energy="-10.5" /TU="U726" /idTUdmin="U726" /TUdmin="-224" /isTUend="FALSE" /label="downshifts" CDS 949604..949795 /gene="yhzG" /locus_tag="BSU_09259" /old_locus_tag="BSU09259" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="PSEUDO:CAX52585.1" /translation="MYSGCALWSFCIFAISYIIQKTARLHIAIAMAVQVVSSATFIST MLSIVTLPVLLWKLHPLSS*" /label="yhzG CDS" gene 949604..949795 /gene="yhzG" /locus_tag="BSU_09259" /old_locus_tag="BSU09259" /pseudo /label="yhzG gene" promotor_-35 949826..949833 /Source="Nicolas_upshift_promotors" /id="U727" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.923076923076923" /psig=1 /xcortree=333 /SigmaFactorBS="aggggatgttttattatttacgcggttTATTGACTctgaccc ggtctggCTTTATATTGAAGGCAGGGAaatcatcaccaagacatcacataaagagaag g" /listShort="S320, yhxA, glpP, S321, glpF, glpK" /listLong="S322, glpD, S323, pgcA" /label="promotor_-35" promotor_-10 949848..949867 /Source="Nicolas_upshift_promotors" /id="U727" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.923076923076923" /psig=1 /xcortree=333 /SigmaFactorBS="aggggatgttttattatttacgcggttTATTGACTctgaccc ggtctggCTTTATATTGAAGGCAGGGAaatcatcaccaagacatcacataaagagaag g" /listShort="S320, yhxA, glpP, S321, glpF, glpK" /listLong="S322, glpD, S323, pgcA" /label="promotor_-10" S_feature 949859..949940 /Source="Nicolas_S_feature" /locus_tag="new_1000282_1000363" /HighExp="M40t90, M0t90, T0.30H, LBGstat, BC, Lbstat, M9-stat, Lbtran, T1.0H, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S320" upshifts 949859 /Source="Nicolas_upshifts" /id="U727" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.923076923076923" /psig=1 /xcortree=333 /SigmaFactorBS="aggggatgttttattatttacgcggttTATTGACTctgaccc ggtctggCTTTATATTGAAGGCAGGGAaatcatcaccaagacatcacataaagagaag g" /listShort="S320, yhxA, glpP, S321, glpF, glpK" /listLong="S322, glpD, S323, pgcA" /label="upshifts" CDS 949941..951293 /gene="yhxA" /locus_tag="BSU_09260" /old_locus_tag="BSU09260" /EC_number="2.6.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11082195, 23610425; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aminotransferase" /protein_id="NP_388807.2" /db_xref="EnsemblGenomes-Gn:BSU09260" /db_xref="EnsemblGenomes-Tr:CAB12754" /db_xref="GOA:P33189" /db_xref="InterPro:IPR005814" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG10184" /db_xref="UniProtKB/Swiss-Prot:P33189" /translation="MEMMGMENIQQNQGLKQKDEQFVWHAMKGAHQADSLIAQKAEGA WVTDTDGRRYLDAMSGLWCVNIGYGRKELAEAAYEQLKELPYYPLTQSHAPAIQLAEK LNEWLGGDYVIFFSNSGSEANETAFKIARQYHLQNGDHSRYKFISRYRAYHGNTLGAL SATGQAQRKYKYEPLSQGFLHAAPPDIYRNPDDADTLESANEIDRIMTWELSETIAGV IMEPIITGGGILMPPDGYMKKVEDICRRHGALLICDEVICGFGRTGEPFGFMHYGVKP DIITMAKGITSAYLPLSATAVKRDIFEAYQGEAPYDRFRHVNTFGGSPAACALALKNL QIMEDEQLIQRSRDLGAKLLGELQALREHPAVGDVRGKGLLIGIELVKDKLTKEPADA AKVNQVVAACKEKGLIIGKNGDTVAGYNNVIQLAPPFCLTEEDLSFIVKTVKESFQTI *" /label="yhxA CDS" gene 949941..951293 /gene="yhxA" /locus_tag="BSU_09260" /old_locus_tag="BSU09260" /label="yhxA gene" CDS 951321..951899 /gene="glpP" /locus_tag="BSU_09270" /old_locus_tag="BSU09270" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11929549, 23610425, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11929549, 23610425, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="sn-glycerol-3-phosphate responding transcriptionantiterminator" /protein_id="NP_388808.1" /db_xref="EnsemblGenomes-Gn:BSU09270" /db_xref="EnsemblGenomes-Tr:CAB12755" /db_xref="GOA:P30300" /db_xref="InterPro:IPR006699" /db_xref="InterPro:IPR035928" /db_xref="SubtiList:BG10185" /db_xref="UniProtKB/Swiss-Prot:P30300" /translation="MMSFHNQPILPAIRNMKQFDEFLNSSFSYGVILDIHLGQLKGVI KEAQKHGKNMMVHVDLIQGIKHDEYGAEFICQDIKPAGIISTRSNVIAKAKQKKIYAI QRLFLLDTSAMEKSMEFIGKHKPDFIEVLPGIVPSLIQEIKEKTGIPIFAGGFIRTEE DVEQALKAGAVAVTTSNTKLWKKYENFLTESD*" /label="glpP CDS" gene 951321..951899 /gene="glpP" /locus_tag="BSU_09270" /old_locus_tag="BSU09270" /label="glpP gene" promotor_-35 951894..951901 /Source="Nicolas_upshift_promotors" /id="U728" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.605394605394605" /psig="0.998001998001998" /xcortree=276 /SigmaFactorBS="aaatatgaaaactttttgacggaaagtGATTGACAccgcttt catgcacTGATACAATTGCACTAGGTTaatacattgtgatggagaactcggagaccac a" /listShort="S321, glpF, glpK, S322, glpD, S323, pgcA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 951916..951935 /Source="Nicolas_upshift_promotors" /id="U728" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.605394605394605" /psig="0.998001998001998" /xcortree=276 /SigmaFactorBS="aaatatgaaaactttttgacggaaagtGATTGACAccgcttt catgcacTGATACAATTGCACTAGGTTaatacattgtgatggagaactcggagaccac a" /listShort="S321, glpF, glpK, S322, glpD, S323, pgcA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 951927 /Source="Nicolas_upshifts" /id="U728" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.605394605394605" /psig="0.998001998001998" /xcortree=276 /SigmaFactorBS="aaatatgaaaactttttgacggaaagtGATTGACAccgcttt catgcacTGATACAATTGCACTAGGTTaatacattgtgatggagaactcggagaccac a" /listShort="S321, glpF, glpK, S322, glpD, S323, pgcA" /GFF_Attribute="listLong" /label="upshifts" downshifts 951942 /Source="Nicolas_upshifts" /id="D479" /incds=0 /nref=3 /ntot=39 /MaxReadThrough="8.20986" /MaxDrop="2.99328" /score="6.07464219" /energy="-10" /TU="U727,U728" /idTUdmin="U726" /TUdmin=2215 /isTUend="FALSE" /label="downshifts" S_feature 951987..952077 /Source="Nicolas_S_feature" /locus_tag="new_1002410_1002500" /HighExp="Diami, T0.30H, G150, Oxctl, Gly, Paraq, dia5, BC, B60, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S321" CDS 952078..952902 /gene="glpF" /locus_tag="BSU_09280" /old_locus_tag="BSU09280" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11929549, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11929549, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="glycerol permease" /protein_id="NP_388809.1" /db_xref="EnsemblGenomes-Gn:BSU09280" /db_xref="EnsemblGenomes-Tr:CAB12756" /db_xref="GOA:P18156" /db_xref="InterPro:IPR000425" /db_xref="InterPro:IPR022357" /db_xref="InterPro:IPR023271" /db_xref="SubtiList:BG10186" /db_xref="UniProtKB/Swiss-Prot:P18156" /translation="MTAFWGEVIGTMLLIIFGAGVCAGVNLKKSLSFQSGWIVVVFGW GLGVAMAAYAVGGISGAHLNPALTIALAFVGDFPWKEVPVYIAAQMIGAIIGAVIIYL HYLPHWKSTDDPAAKLGVFSTGPSIPHTFANVLSEVIGTFVLVLGILAIGANQFTEGL NPLIVGFLIVAIGISLGGTTGYAINPARDLGPRIAHAFLPIPGKGSSNWKYAWVPVVG PILGGSFGGVFYNAAFKGHITSSFWIVSVILVVVLLGLYVYTKSHSAKTLSNSKYI*" /label="glpF CDS" gene 952078..952902 /gene="glpF" /locus_tag="BSU_09280" /old_locus_tag="BSU09280" /label="glpF gene" CDS 952921..954411 /gene="glpK" /locus_tag="BSU_09290" /old_locus_tag="BSU09290" /EC_number="2.7.1.30" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9972264, 10920256, 11929549, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycerol kinase (sn-glycerol-3-phosphate generating)" /protein_id="NP_388810.2" /db_xref="EnsemblGenomes-Gn:BSU09290" /db_xref="EnsemblGenomes-Tr:CAB12757" /db_xref="GOA:P18157" /db_xref="InterPro:IPR000577" /db_xref="InterPro:IPR005999" /db_xref="InterPro:IPR018483" /db_xref="InterPro:IPR018484" /db_xref="InterPro:IPR018485" /db_xref="SubtiList:BG10187" /db_xref="UniProtKB/Swiss-Prot:P18157" /translation="METYILSLDQGTTSSRAILFNKEGKIVHSAQKEFTQYFPHPGWV EHNANEIWGSVLAVIASVISESGISASQIAGIGITNQRETTVVWDKDTGSPVYNAIVW QSRQTSGICEELREKGYNDKFREKTGLLIDPYFSGTKVKWILDNVEGAREKAEKGELL FGTIDTWLIWKMSGGKAHVTDYSNASRTLMFNIYDLKWDDELLDILGVPKSMLPEVKP SSHVYAETVDYHFFGKNIPIAGAAGDQQSALFGQACFEEGMGKNTYGTGCFMLMNTGE KAIKSEHGLLTTIAWGIDGKVNYALEGSIFVAGSAIQWLRDGLRMFQDSSLSESYAEK VDSTDGVYVVPAFVGLGTPYWDSDVRGSVFGLTRGTTKEHFIRATLESLAYQTKDVLD AMEADSNISLKTLRVDGGAVKNNFLMQFQGDLLNVPVERPEINETTALGAAYLAGIAV GFWKDRSEIANQWNLDKRFEPELEEEKRNELYKGWQKAVKAAMAFK*" /label="glpK CDS" gene 952921..954411 /gene="glpK" /locus_tag="BSU_09290" /old_locus_tag="BSU09290" /label="glpK gene" promotor_-35 953722..953728 /Source="Nicolas_upshift_promotors" /id="U729" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=149 /SigmaFactorBS="gcatggggaaaaacacttacggcacaggaTGTTTCAtgctga tgaataccGGGGAAAAAGCAATTAAGTCcgaacatgggcttttgacaacaatcgcttg g" /listShort="S322, glpD, S323" /listLong="pgcA" /label="promotor_-35" promotor_-10 953743..953762 /Source="Nicolas_upshift_promotors" /id="U729" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=149 /SigmaFactorBS="gcatggggaaaaacacttacggcacaggaTGTTTCAtgctga tgaataccGGGGAAAAAGCAATTAAGTCcgaacatgggcttttgacaacaatcgcttg g" /listShort="S322, glpD, S323" /listLong="pgcA" /label="promotor_-10" upshifts 953753 /Source="Nicolas_upshifts" /id="U729" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=149 /SigmaFactorBS="gcatggggaaaaacacttacggcacaggaTGTTTCAtgctga tgaataccGGGGAAAAAGCAATTAAGTCcgaacatgggcttttgacaacaatcgcttg g" /listShort="S322, glpD, S323" /listLong="pgcA" /label="upshifts" S_feature 954412..954500 /Source="Nicolas_S_feature" /locus_tag="new_1004835_1004923" /HighExp="Sw, Etha, Salt, G150, Gly, Diami, T0.30H, B60, BC, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigA" /TUshortPSig="1, 0.998" /TUlongSig="SigA" /TUlongPSig=1 /label="S322" downshifts 954457 /Source="Nicolas_upshifts" /id="D480" /incds=0 /nref=34 /ntot=91 /MaxReadThrough="7.63856" /MaxDrop="5.2045" /score="21.1943866" /energy="-28.7" /TU="U728,U729" /idTUdmin="U727" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_no_box 954463..954563 /Source="Nicolas_upshift_promotors" /id="U730" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.566433566433566" /psig="0.154845154845155" /xcortree=277 /SigmaFactorBS="aggagagaccacagcaccaaagtgtaagcatgcactttggct gttgtggtctctttttctatttaccgtgacaacaaggaggaaacgtaatgatgaatca t" /listShort="glpD, S323, pgcA" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 954523 /Source="Nicolas_upshifts" /id="U730" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.566433566433566" /psig="0.154845154845155" /xcortree=277 /SigmaFactorBS="aggagagaccacagcaccaaagtgtaagcatgcactttggct gttgtggtctctttttctatttaccgtgacaacaaggaggaaacgtaatgatgaatca t" /listShort="glpD, S323, pgcA" /GFF_Attribute="listLong" /label="upshifts" CDS 954552..956219 /gene="glpD" /locus_tag="BSU_09300" /old_locus_tag="BSU09300" /EC_number="1.1.3.21" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2127799, 8825777, 9595668, 10633102, 18946204" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2127799, 8825777, 9595668, 10633102, 18946204; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sn-glycerol-3-phosphate oxidase (FAD-dependent)" /protein_id="NP_388811.2" /db_xref="EnsemblGenomes-Gn:BSU09300" /db_xref="EnsemblGenomes-Tr:CAB12758" /db_xref="GOA:P18158" /db_xref="InterPro:IPR000447" /db_xref="InterPro:IPR006076" /db_xref="InterPro:IPR031656" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG10188" /db_xref="UniProtKB/Swiss-Prot:P18158" /translation="MMNHQFSSLERDRMLTDMTKKTYDLFIIGGGITGAGTALDAASR GMKVALSEMQDFAAGTSSRSTKLVHGGLRYLKQFEVKMVAEVGKERAIVYENGPHVTT PEWMLLPFHKGGTFGSFTTSIGLRVYDFLAGVKKSERRSMLSAKETLQKEPLVKKDGL KGGGYYVEYRTDDARLTIEVMKEAVKFGAEPVNYSKVKELLYEKGKAVGVLIEDVLTK KEYKVYAKKIVNATGPWVDQLREKDHSKNGKHLQHTKGIHLVFDQSVFPLKQAVYFDT PDGRMVFAIPREGKTYVGTTDTVYKEALEHPRMTTEDRDYVIKSINYMFPELNITAND IESSWAGLRPLIHEEGKDPSEISRKDEIWTSDSGLITIAGGKLTGYRKMAEHIVDLVR DRLKEEGEKDFGPCKTKNMPISGGHVGGSKNLMSFVTAKTKEGIAAGLSEKDAKQLAI RYGSNVDRVFDRVEALKDEAAKRNIPVHILAEAEYSIEEEMTATPADFFVRRTGRLFF DINWVRTYKDAVIDFMSERFQWDEQAKNKHTENLNKLLHDAVVPLEQ*" /label="glpD CDS" gene 954552..956219 /gene="glpD" /locus_tag="BSU_09300" /old_locus_tag="BSU09300" /label="glpD gene" promotor_-35 955981..955986 /Source="Nicolas_upshift_promotors" /id="U731" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1176 /SigmaFactorBS="aaagatgaggccgcgaaacgcaacattccggTTCATAttctt gctgaggcaGAATACAGTATAGAAGAAGagatgactgcaacccctgctgacttctttg t" /listShort="S323" /listLong="pgcA" /label="promotor_-35" promotor_-10 956001..956019 /Source="Nicolas_upshift_promotors" /id="U731" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1176 /SigmaFactorBS="aaagatgaggccgcgaaacgcaacattccggTTCATAttctt gctgaggcaGAATACAGTATAGAAGAAGagatgactgcaacccctgctgacttctttg t" /listShort="S323" /listLong="pgcA" /label="promotor_-10" upshifts 956010 /Source="Nicolas_upshifts" /id="U731" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1176 /SigmaFactorBS="aaagatgaggccgcgaaacgcaacattccggTTCATAttctt gctgaggcaGAATACAGTATAGAAGAAGagatgactgcaacccctgctgacttctttg t" /listShort="S323" /listLong="pgcA" /label="upshifts" promotor_-35 956064..956070 /Source="Nicolas_upshift_promotors" /id="U732" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=255 /SigmaFactorBS="actgcaacccctgctgacttctttgtccgcagaacgggaCGT TTATtttttgatatcaattGGGTAAGAACATATAAAGAtgccgttattgattttatga g" /listShort="S323, pgcA, S324, yhcY, yhcZ, yhdA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 956085 /Source="Nicolas_upshifts" /id="U732" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=255 /SigmaFactorBS="actgcaacccctgctgacttctttgtccgcagaacgggaCGT TTATtttttgatatcaattGGGTAAGAACATATAAAGAtgccgttattgattttatga g" /listShort="S323, pgcA, S324, yhcY, yhcZ, yhdA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 956086..956104 /Source="Nicolas_upshift_promotors" /id="U732" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=255 /SigmaFactorBS="actgcaacccctgctgacttctttgtccgcagaacgggaCGT TTATtttttgatatcaattGGGTAAGAACATATAAAGAtgccgttattgattttatga g" /listShort="S323, pgcA, S324, yhcY, yhcZ, yhdA" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 956187 /Source="Nicolas_upshifts" /id="D481" /incds=0 /nref=13 /ntot=60 /MaxReadThrough="6.57605" /MaxDrop="4.31183" /score="11.5542287" /energy="-11.4" /TU="U728,U729,U730,U731,U732" /idTUdmin="U729" /TUdmin="-118" /isTUend="FALSE" /label="downshifts" S_feature 956232..956305 /Source="Nicolas_S_feature" /locus_tag="new_1006655_1006728" /HighExp="G150, Etha, Oxctl, H2O2, Gly, Diami, Paraq, Salt, B36, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigEF, Sig-, SigB, SigA" /TUshortPSig="1, 0.995, 0.155, 1, 0.998" /TUlongSig="SigA" /TUlongPSig=1 /label="S323" promotor_-35 956287..956294 /Source="Nicolas_upshift_promotors" /id="U733" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig="0.998001998001998" /xcortree=1942 /SigmaFactorBS="atttctttttacgtgccgaaagggggagatctcaggttatCA AGTGACagaggcacccgctTCATATAAAATAATGGCATAagctgatacataggaggac g" /listShort="pgcA, S324, yhcY, yhcZ, yhdA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 956307 /Source="Nicolas_upshifts" /id="U733" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig="0.998001998001998" /xcortree=1942 /SigmaFactorBS="atttctttttacgtgccgaaagggggagatctcaggttatCA AGTGACagaggcacccgctTCATATAAAATAATGGCATAagctgatacataggaggac g" /listShort="pgcA, S324, yhcY, yhcZ, yhdA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 956308..956327 /Source="Nicolas_upshift_promotors" /id="U733" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig="0.998001998001998" /xcortree=1942 /SigmaFactorBS="atttctttttacgtgccgaaagggggagatctcaggttatCA AGTGACagaggcacccgctTCATATAAAATAATGGCATAagctgatacataggaggac g" /listShort="pgcA, S324, yhcY, yhcZ, yhdA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 956351..958096 /gene="pgcA" /locus_tag="BSU_09310" /old_locus_tag="BSU09310" /EC_number="5.4.2.2" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15640167, 17662947, 24097947, 26735940, 27684739" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15640167, 17662947, 24097947, 26735940, 27684739; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alpha-phosphoglucomutase" /protein_id="NP_388812.2" /db_xref="EnsemblGenomes-Gn:BSU09310" /db_xref="EnsemblGenomes-Tr:CAB12759" /db_xref="GOA:P18159" /db_xref="InterPro:IPR005841" /db_xref="InterPro:IPR005843" /db_xref="InterPro:IPR005844" /db_xref="InterPro:IPR005845" /db_xref="InterPro:IPR005846" /db_xref="InterPro:IPR016055" /db_xref="InterPro:IPR016066" /db_xref="InterPro:IPR036900" /db_xref="SubtiList:BG10189" /db_xref="UniProtKB/Swiss-Prot:P18159" /translation="MTWRKSYERWKQTEHLDLELKERLIELEGDEQALEDCFYKDLEF GTGGMRGEIGAGTNRMNIYTVRKASAGFAAYISKQGEEAKKRGVVIAYDSRHKSPEFA MEAAKTLATQGIQTYVFDELRPTPELSFAVRQLNAYGGIVVTASHNPPEYNGYKVYGD DGGQLPPKEADIVIEQVNAIENELTITVDEENKLKEKGLIKIIGEDIDKVYTEKLTSI SVHPELSEEVDVKVVFTPLHGTANKPVRRGLEALGYKNVTVVKEQELPDSNFSTVTSP NPEEHAAFEYAIKLGEEQNADILIATDPDADRLGIAVKNDQGKYTVLTGNQTGALLLH YLLSEKKKQGILPDNGVVLKTIVTSEIGRAVASSFGLDTIDTLTGFKFIGEKIKEYEA SGQYTFQFGYEESYGYLIGDFARDKDAIQAALLAVEVCAFYKKQGMSLYEALINLFNE YGFYREGLKSLTLKGKQGAEQIEAILASFRQNPPQKMAGKQVVTAEDYAVSKRTLLTE SKEEAIDLPKSNVLKYFLEDGSWFCLRPSGTEPKVKFYFAVKGSSLEDSEKRLAVLSE DVMKTVDEIVESTAK*" /label="pgcA CDS" gene 956351..958096 /gene="pgcA" /locus_tag="BSU_09310" /old_locus_tag="BSU09310" /label="pgcA gene" downshifts 958085 /Source="Nicolas_upshifts" /id="D482" /incds=0 /nref=227 /ntot=264 /MaxReadThrough="4.80136" /MaxDrop="5.89896" /score="26.7163878" /energy="-13" /TU="U732,U733" /idTUdmin="U728" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" S_feature 958130..958199 /Source="Nicolas_S_feature" /locus_tag="new_1008553_1008622" /HighExp="Etha, H2O2, B36, dia15, Paraq, G150, LoTm, S8, Oxctl, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="0.998, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S324" misc_feature 958201..958220 /Source="Nicolas_upshift_promotors" /id="U734" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.62037962037962" /psig="0.998001998001998" /xcortree=3137 /SigmaFactorBS="tttctcatccaaaagtctgaaagaaaatcatcctacaagtga agcaatgaaatacaaaaaACTGGTATAATCTTAAATACaagatcaatgccggagtgag a" /listShort="yhcY, yhcZ, yhdA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 958201 /Source="Nicolas_upshifts" /id="U734" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.62037962037962" /psig="0.998001998001998" /xcortree=3137 /SigmaFactorBS="tttctcatccaaaagtctgaaagaaaatcatcctacaagtga agcaatgaaatacaaaaaACTGGTATAATCTTAAATACaagatcaatgccggagtgag a" /listShort="yhcY, yhcZ, yhdA" /GFF_Attribute="listLong" /label="upshifts" CDS 958245..959384 /gene="yhcY" /locus_tag="BSU_09320" /old_locus_tag="BSU09320" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295, 16816187, 16267314, 20639339, 21335452" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 16816187, 16267314, 20639339, 21335452; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YhcZ]" /protein_id="NP_388813.1" /db_xref="EnsemblGenomes-Gn:BSU09320" /db_xref="EnsemblGenomes-Tr:CAB12760" /db_xref="GOA:O07527" /db_xref="InterPro:IPR003018" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR029016" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG13005" /db_xref="UniProtKB/Swiss-Prot:O07527" /translation="MSKTRMEKLKTLKTIAETLNQGHDIKATLDEVLKELLSLTNLQS GWIFLIEEDGSYTLAADAYLPPALSRKEKVLMCEGECYCLTKFNNGGLRKAANIMNCK RIESAENLHCFDTEGITHHATVPLEDGDRRFGLLNVAAAGKTMFDEEELHLLESVAFQ IGTAIQRMRLSEYQQKNALLMERNRLAQELHDSVNQMLFSVSLTAKAAKTLTKDENLQ QMIDFIQNLSQDALAEMKALIWQLRPGGLEKGLAEAIKSYGALIGLKIIFTQKGCPVL TDEQEHMLWRVVQEALNNCKKHAGTDTAYVSLTASLCHAELDIIDHGAGFRYEAHAGL PSLGIKGMKERAEKAGAKFWIESALGTGTKLSIRLPLKSRKGGAV*" /label="yhcY CDS" gene 958245..959384 /gene="yhcY" /locus_tag="BSU_09320" /old_locus_tag="BSU09320" /label="yhcY gene" CDS 959381..960025 /gene="yhcZ" /locus_tag="BSU_09330" /old_locus_tag="BSU09330" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 16816187, 16267314, 20639339, 21335452" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 16816187, 16267314, 20639339, 21335452; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YhcY]" /protein_id="NP_388814.1" /db_xref="EnsemblGenomes-Gn:BSU09330" /db_xref="EnsemblGenomes-Tr:CAB12761" /db_xref="GOA:O07528" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG13006" /db_xref="UniProtKB/Swiss-Prot:O07528" /translation="MKIVIADDHHVVRKGLRFFFATQDDIEVVGEAATGLEALRVIEE TKPDLVLMDLSMPEMDGIQAIKKAIQQFPDTNIIVLTSYSDQEHVIPALQAGAKAYQL KDTEPEELVKTRQVHGGEYKLSTAIMPHVLTHMKNQHDPEKEKYYQLTRREKDVLTEI ANGKSNKEIAAALFISEKTVKTHVSNLLAKLEVADRTQAALFAVKYNLNGEISK*" /label="yhcZ CDS" gene 959381..960025 /gene="yhcZ" /locus_tag="BSU_09330" /old_locus_tag="BSU09330" /label="yhcZ gene" CDS 960022..960546 /gene="azr" /locus_tag="BSU_09340" /old_locus_tag="BSU09340" /EC_number="1.7.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15184374, 16816187, 20639339; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="oxidoreductase, NAD(P)H-FMN and ferric iron reductase (azoreductase)" /protein_id="NP_388815.1" /db_xref="EnsemblGenomes-Gn:BSU09340" /db_xref="EnsemblGenomes-Tr:CAB12762" /db_xref="GOA:O07529" /db_xref="InterPro:IPR005025" /db_xref="InterPro:IPR029039" /db_xref="PDB:1NNI" /db_xref="PDB:2GSW" /db_xref="PDB:3GFQ" /db_xref="PDB:3GFR" /db_xref="PDB:3GFS" /db_xref="SubtiList:BG13007" /db_xref="UniProtKB/Swiss-Prot:O07529" /translation="MNMLVINGTPRKHGRTRIAASYIAALYHTDLIDLSEFVLPVFNG EAEQSELLKVQELKQRVTKADAIVLLSPEYHSGMSGALKNALDFLSSEQFKYKPVALL AVAGGGKGGINALNNMRTVMRGVYANVIPKQLVLDPVHIDVENATVAENIKESIKELV EELSMFAKAGNPGV*" /label="azr CDS" gene 960022..960546 /gene="azr" /locus_tag="BSU_09340" /old_locus_tag="BSU09340" /label="azr gene" downshifts 960511 /Source="Nicolas_upshifts" /id="D483" /incds=0 /nref=72 /ntot=215 /MaxReadThrough="2.90096" /MaxDrop="4.78561" /score="27.1269177" /energy="-17.2" /TU="NA" /idTUdmin="U734" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(960561..960803) /gene="yhdB" /locus_tag="BSU_09350" /old_locus_tag="BSU09350" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388816.1" /db_xref="EnsemblGenomes-Gn:BSU09350" /db_xref="EnsemblGenomes-Tr:CAB12763" /db_xref="InterPro:IPR025431" /db_xref="SubtiList:BG13008" /db_xref="UniProtKB/Swiss-Prot:O07530" /translation="MDYADYDKALYYTHRSQWDNLLILMVRTEDDLLSKRIEHFLHAY HFEQDYAVLEKMLYSLLRYIDHATELTYEDQIALLT*" /label="yhdB CDS" gene complement(960561..960803) /gene="yhdB" /locus_tag="BSU_09350" /old_locus_tag="BSU09350" /label="yhdB gene" downshifts complement(960582) /Source="Nicolas_upshifts" /id="D484" /incds=0 /nref=39 /ntot=84 /MaxReadThrough="-0.0235599999999998" /MaxDrop="7.78706" /score="12.0066876" /energy="-17.2" /TU="NA" /idTUdmin="U735" /TUdmin="-17" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(960839..960850) /Source="Nicolas_upshift_promotors" /id="U735" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.556443556443556" /psig="0.556443556443556" /xcortree=833 /SigmaFactorBS="attgctacccctttactgacgcagacggcaagttttgccCCG TCAATaacagaggatgcgGCATAAACTAATcatgaacttctcacccaagaaaggagaa g" /listShort="yhdB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(960850) /Source="Nicolas_upshifts" /id="U735" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.556443556443556" /psig="0.556443556443556" /xcortree=833 /SigmaFactorBS="attgctacccctttactgacgcagacggcaagttttgccCCG TCAATaacagaggatgcgGCATAAACTAATcatgaacttctcacccaagaaaggagaa g" /listShort="yhdB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(960864..960871) /Source="Nicolas_upshift_promotors" /id="U735" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.556443556443556" /psig="0.556443556443556" /xcortree=833 /SigmaFactorBS="attgctacccctttactgacgcagacggcaagttttgccCCG TCAATaacagaggatgcgGCATAAACTAATcatgaacttctcacccaagaaaggagaa g" /listShort="yhdB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 960938..960944 /Source="Nicolas_upshift_promotors" /id="U736" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=929 /SigmaFactorBS="aatatgagggagacataaaatcaaaatgccTGAATGAagata tcgcttttGGTAAACCTATGagggaatatattctgggtacaggagactgaaaaaatga a" /listShort="yhdC, S325" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 960958..960969 /Source="Nicolas_upshift_promotors" /id="U736" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=929 /SigmaFactorBS="aatatgagggagacataaaatcaaaatgccTGAATGAagata tcgcttttGGTAAACCTATGagggaatatattctgggtacaggagactgaaaaaatga a" /listShort="yhdC, S325" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 960968 /Source="Nicolas_upshifts" /id="U736" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=929 /SigmaFactorBS="aatatgagggagacataaaatcaaaatgccTGAATGAagata tcgcttttGGTAAACCTATGagggaatatattctgggtacaggagactgaaaaaatga a" /listShort="yhdC, S325" /GFF_Attribute="listLong" /label="upshifts" CDS 961004..961327 /gene="yhdC" /locus_tag="BSU_09360" /old_locus_tag="BSU09360" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_388817.1" /db_xref="EnsemblGenomes-Gn:BSU09360" /db_xref="EnsemblGenomes-Tr:CAB12764" /db_xref="InterPro:IPR024987" /db_xref="SubtiList:BG13009" /db_xref="UniProtKB/Swiss-Prot:O07531" /translation="MKSLPYTIALLFCGLIIVSMAAKGHSTDTDESVQKWEQLAWSKI QDEYKGASFSDYAYMGRTEVNDQQTKDVFRVTVRQKDDTFSVRAEVYFHPVTNHMISI NVFRL*" /label="yhdC CDS" gene 961004..961327 /gene="yhdC" /locus_tag="BSU_09360" /old_locus_tag="BSU09360" /label="yhdC gene" S_feature 961328..963194 /Source="Nicolas_S_feature" /locus_tag="new_1011751_1013617" /HighExp="S8, S5, S7, S6, S4, C30, Sw, ferm, S3, BC" /AntisenseName="lytF" /AntisenseCor="-0.65564579825076796" /AntisenseRegPval="-33.700000000000003" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S325" CDS complement(961369..962835) /gene="lytF" /locus_tag="BSU_09370" /old_locus_tag="BSU09370" /EC_number="3.4.-.-" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10206711, 14594841, 18761694, 18761696, 23091053, 25288647" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10206711, 14594841, 18761694, 18761696, 23091053, 25288647; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="gamma-D-glutamate-meso-diaminopimelate muropeptidase (major autolysin, vegetative)" /protein_id="NP_388818.2" /db_xref="EnsemblGenomes-Gn:BSU09370" /db_xref="EnsemblGenomes-Tr:CAB12776" /db_xref="GOA:O07532" /db_xref="InterPro:IPR000064" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG13010" /db_xref="UniProtKB/Swiss-Prot:O07532" /translation="MKKKLAAGLTASAIVGTTLVVTPAEAATIKVKSGDSLWKLAQTY NTSVAALTSANHLSTTVLSIGQTLTIPGSKSSTSSSTSSSTTKKSGSSVYTVKSGDSL WLIANEFKMTVQELKKLNGLSSDLIRAGQKLKVSGTVSSSSSSSKKSNSNKSSSSSSK SSSNKSSSSSSSTGTYKVQLGDSLWKIANKVNMSIAELKVLNNLKSDTIYVNQVLKTK SSGSDTSSKDNSSKSNQTSATTKYTVKSGDSLWKIANNYNLTVQQIRNINNLKSDVLY VGQVLKLTGKASSGSSSSSSSSSNASSGTTTTYTVKSGDSLWVIAQKFNVTAQQIREK NNLKTDVLQVGQKLVISGKASSSSSSGSSNTTSSTSAKINTMISAAKAQLGVPYRWGG TTPSGFDCSGFIYYVLNKVTSVSRLTAAGYWNTMKSVSQPAVGDFVFFSTYKAGPSHV GIYLGNGEFINANDSGVVISNMNNSYWKQRYLGAKRYF*" /label="lytF CDS" gene complement(961369..962835) /gene="lytF" /locus_tag="BSU_09370" /old_locus_tag="BSU09370" /label="lytF gene" downshifts complement(961381) /Source="Nicolas_upshifts" /id="D485" /incds=0 /nref=121 /ntot=216 /MaxReadThrough="2.34529" /MaxDrop="4.33563" /score="24.6732339" /energy="-14.2" /TU="NA" /idTUdmin="U737" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" downshifts complement(961468) /Source="Nicolas_upshifts" /id="D486" /incds=1 /nref=1 /ntot=87 /MaxReadThrough="5.73069" /MaxDrop="2.6306" /score="24.6732339" /energy="-14.2" /TU="U737" /idTUdmin="U737" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(962875..962893) /Source="Nicolas_upshift_promotors" /id="U737" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2806 /SigmaFactorBS="ttgttaagataatttggctatttttataaaaagGCAAAACGa tgagacaaatgtGCCGATATAAAAAAGAAACagcaaatgcaaaatcattgggggaaaa a" /listShort="lytF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(962887) /Source="Nicolas_upshifts" /id="U737" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2806 /SigmaFactorBS="ttgttaagataatttggctatttttataaaaagGCAAAACGa tgagacaaatgtGCCGATATAAAAAAGAAACagcaaatgcaaaatcattgggggaaaa a" /listShort="lytF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(962907..962914) /Source="Nicolas_upshift_promotors" /id="U737" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2806 /SigmaFactorBS="ttgttaagataatttggctatttttataaaaagGCAAAACGa tgagacaaatgtGCCGATATAAAAAAGAAACagcaaatgcaaaatcattgggggaaaa a" /listShort="lytF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(962988..963428) /gene="nsrR" /locus_tag="BSU_09380" /old_locus_tag="BSU09380" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16885456, 19006327, 21091510, 26887943, 27778474, 28425466, 28439033" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16885456, 19006327, 21091510, 26887943, 27778474, 28425466, 28439033; Product type r: regulator" /codon_start=1 /transl_table=11 /product="NO-dependent activator of the ResDE regulon (Fe-S NO binding site)" /protein_id="NP_388819.1" /db_xref="EnsemblGenomes-Gn:BSU09380" /db_xref="EnsemblGenomes-Tr:CAB12777" /db_xref="GOA:O07573" /db_xref="InterPro:IPR000944" /db_xref="InterPro:IPR030489" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13011" /db_xref="UniProtKB/Swiss-Prot:O07573" /translation="MKLTNYTDYSLRVLIFLAAERPGELSNIKQIAETYSISKNHLMK VIYRLGQLGYVETIRGRGGGIRLGMDPEDINIGEVVRKTEDDFNIVECFDANKNLCVI SPVCGLKHVLNEALLAYLAVLDKYTLRDLVKNKEDIMKLLKMKE*" /label="nsrR CDS" gene complement(962988..963428) /gene="nsrR" /locus_tag="BSU_09380" /old_locus_tag="BSU09380" /label="nsrR gene" downshifts complement(963018) /Source="Nicolas_upshifts" /id="D487" /incds=0 /nref=205 /ntot=265 /MaxReadThrough="3.11158" /MaxDrop="6.87147" /score="5.96186156" /energy="-7.8" /TU="U739" /idTUdmin="U740" /TUdmin="-10" /isTUend="TRUE" /label="downshifts" promotor_-35 963416..963422 /Source="Nicolas_upshift_promotors" /id="U738" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.904095904095904" /psig="0.904095904095904" /xcortree=408 /SigmaFactorBS="cagaaaaatcaacactcttaatgaataatctgtataatTGGT TAActtcataataagaCCTCAGAATAAGacattttctatatcttatcataatcgattg a" /listShort="S326" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 963436..963447 /Source="Nicolas_upshift_promotors" /id="U738" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.904095904095904" /psig="0.904095904095904" /xcortree=408 /SigmaFactorBS="cagaaaaatcaacactcttaatgaataatctgtataatTGGT TAActtcataataagaCCTCAGAATAAGacattttctatatcttatcataatcgattg a" /listShort="S326" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 963438..963548 /Source="Nicolas_S_feature" /locus_tag="new_1013861_1013971" /HighExp="S8, S7, S4, Sw, S5, S6, BC, B60, nit, Pyr" /AntisenseName="ygxB" /AntisenseCor="-0.211236686077168" /AntisenseRegPval="-3.3" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.904" /TUlongSig="NA" /TUlongPSig="NA" /label="S326" upshifts 963438 /Source="Nicolas_upshifts" /id="U738" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.904095904095904" /psig="0.904095904095904" /xcortree=408 /SigmaFactorBS="cagaaaaatcaacactcttaatgaataatctgtataatTGGT TAActtcataataagaCCTCAGAATAAGacattttctatatcttatcataatcgattg a" /listShort="S326" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(963450..963469) /Source="Nicolas_upshift_promotors" /id="U739" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3120 /SigmaFactorBS="catgcacccagctgggtgcatgttttttaattcctttttTTT CATTtttcaatcgatTATGATAAGATATAGAAAATgtcttattctgaggtcttattat g" /listShort="nsrR, lytF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(963466) /Source="Nicolas_upshifts" /id="U739" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3120 /SigmaFactorBS="catgcacccagctgggtgcatgttttttaattcctttttTTT CATTtttcaatcgatTATGATAAGATATAGAAAATgtcttattctgaggtcttattat g" /listShort="nsrR, lytF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(963481..963487) /Source="Nicolas_upshift_promotors" /id="U739" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3120 /SigmaFactorBS="catgcacccagctgggtgcatgttttttaattcctttttTTT CATTtttcaatcgatTATGATAAGATATAGAAAATgtcttattctgaggtcttattat g" /listShort="nsrR, lytF" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 963507 /Source="Nicolas_upshifts" /id="D488" /incds=0 /nref=10 /ntot=68 /MaxReadThrough="1.05981" /MaxDrop="6.25571" /score="22.5171081" /energy="-11.6" /TU="NA" /idTUdmin="U738" /TUdmin=3 /isTUend="TRUE" /label="downshifts" CDS complement(963535..965193) /gene="ygxB" /locus_tag="BSU_09390" /old_locus_tag="BSU09390" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_388820.1" /db_xref="EnsemblGenomes-Gn:BSU09390" /db_xref="EnsemblGenomes-Tr:CAB12778" /db_xref="GOA:P37874" /db_xref="InterPro:IPR008910" /db_xref="SubtiList:BG10181" /db_xref="UniProtKB/Swiss-Prot:P37874" /translation="MYEPARQKMIVSLGQEKIPPAHSSVCLLDKWVNTHHTTKKERYQ LNVADVFSSYLSKLPNVIIALLVLLIGWAIAKIIEKAVYKGLSKTKIDDKLFAGKKPS RYSSEKVISKVVYFIALIIVFILFFNILHLTTVASPFVSMLSAIAAAIPSVLKAGLIL LLGWAAASVLSFLVKKIGMKLNTSDKLRKWNLVSEGKDIHQAVNTASQIVFYLVLLVF LPGVLSSLKISGISGPFTNMMESVLAFLPKLFAAALIVLIGWLVARLVRDIITNFLAS IGTERFAARMGLSIYLKDTSLSAVIGTIAYVLIMIPVVISALDQLDVAGISKPAVSML NTILNMLPNIMIAIVLVLAGIWAGKWVKSMVSGLLHRAGFDSVLGKMGMEAGTPAKLS LSQVVGMIAQIIVILLFTAEALQIVRLHFLVEIATGIIAYLPNVLVAVFILGLGLYAG ELVRKVLASMIKGQEFKSLAPIAKYTIIALAFFMALDQLGVAATIVNSAFIIVLSGFA LAFGLSFGLGGKDFASRYLSTFERKMQNTEIEKNRKNQNPPNDM*" /label="ygxB CDS" gene complement(963535..965193) /gene="ygxB" /locus_tag="BSU_09390" /old_locus_tag="BSU09390" /label="ygxB gene" downshifts complement(963540) /Source="Nicolas_upshifts" /id="D489" /incds=0 /nref=6 /ntot=40 /MaxReadThrough="8.34865" /MaxDrop="5.55332" /score="-5.46969987" /energy="-14.5" /TU="U740" /idTUdmin="U740" /TUdmin="-532" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(965084..965102) /Source="Nicolas_upshift_promotors" /id="U740" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=189 /SigmaFactorBS="agtctcactcgggcaagaaaaaattcccccggcacattcatc TGTTTGCttattggataagtGGGTAAACACACACCATACtacgaaaaaggagcgatac c" /listShort="nsrR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(965104) /Source="Nicolas_upshifts" /id="U740" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=189 /SigmaFactorBS="agtctcactcgggcaagaaaaaattcccccggcacattcatc TGTTTGCttattggataagtGGGTAAACACACACCATACtacgaaaaaggagcgatac c" /listShort="nsrR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(965116..965122) /Source="Nicolas_upshift_promotors" /id="U740" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=189 /SigmaFactorBS="agtctcactcgggcaagaaaaaattcccccggcacattcatc TGTTTGCttattggataagtGGGTAAACACACACCATACtacgaaaaaggagcgatac c" /listShort="nsrR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 965165..965170 /Source="Nicolas_upshift_promotors" /id="U741" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1163 /SigmaFactorBS="gaattttttcttgcccgagtgagactATCATCttttgtctgg cgggcTCATACATTATAGATAAGTccaagtaggggggattcggttgaacgcggaggag a" /listShort="spoVR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 965186..965204 /Source="Nicolas_upshift_promotors" /id="U741" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1163 /SigmaFactorBS="gaattttttcttgcccgagtgagactATCATCttttgtctgg cgggcTCATACATTATAGATAAGTccaagtaggggggattcggttgaacgcggaggag a" /listShort="spoVR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 965199 /Source="Nicolas_upshifts" /id="U741" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1163 /SigmaFactorBS="gaattttttcttgcccgagtgagactATCATCttttgtctgg cgggcTCATACATTATAGATAAGTccaagtaggggggattcggttgaacgcggaggag a" /listShort="spoVR" /GFF_Attribute="listLong" /label="upshifts" CDS 965224..966630 /gene="spoVR" /locus_tag="BSU_09400" /old_locus_tag="BSU09400" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:8144469, 14680823" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8144469, 14680823; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="involved in spore cortex synthesis (stage V sporulation, conserved in non sporulating bacteria" /protein_id="NP_388821.1" /db_xref="EnsemblGenomes-Gn:BSU09400" /db_xref="EnsemblGenomes-Tr:CAB12779" /db_xref="GOA:P37875" /db_xref="InterPro:IPR007390" /db_xref="SubtiList:BG10182" /db_xref="UniProtKB/Swiss-Prot:P37875" /translation="MNAEEKKGLQRAIEEITEIAKGFGLDFYPMRYEICPAEIIYTFG AYGMPTRFSHWSFGKQFHKMKLHYDLGLSKIYELVINSDPCYAFLLDSNSLIQNKLIV AHVLAHCDFFKNNCRFQNTKRDMVESMAATAERIKHYEQVHGIKEVESFLDAILSIQE HIDPSLVRPKLQWSVDDEEEEIEEAATPYDDLWSLDEKKPKKQVKKSKKPFPPRPEKD ILLFIEEHSRELEPWQRDILTMMREEMLYFWPQLETKIMNEGWASYWHQRIIRELDLT SDEAIEFAKLNAGVVQPSKTGINPYYLGLKIFEDIEKRYNNPTEEMKKMGVQPDSGRE KMFEVREIESDISFIRNYLTKELVMREDLYLFQKQGRDYKIIDKQWKSVRDQLVSMRV NGGFPYLTVNDGDYMKNNELYIKHWYEGIELDLKYLEKVLPYLFQLWGRSVHIESVLE DKEVMFSYDGKGVHRRYL*" /label="spoVR CDS" gene 965224..966630 /gene="spoVR" /locus_tag="BSU_09400" /old_locus_tag="BSU09400" /label="spoVR gene" downshifts 966610 /Source="Nicolas_upshifts" /id="D490" /incds=0 /nref=43 /ntot=84 /MaxReadThrough="1.30719" /MaxDrop="6.74388" /score="26.4488835" /energy="-11.5" /TU="NA" /idTUdmin="U741" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(966660..968045) /gene="phoA" /locus_tag="BSU_09410" /old_locus_tag="BSU09410" /EC_number="3.1.3.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8830275, 10913081, 12897025, 16491025" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8830275, 10913081, 12897025, 16491025; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alkaline phosphatase A" /protein_id="NP_388822.2" /db_xref="EnsemblGenomes-Gn:BSU09410" /db_xref="EnsemblGenomes-Tr:CAB12780" /db_xref="GOA:P19406" /db_xref="InterPro:IPR001952" /db_xref="InterPro:IPR017849" /db_xref="InterPro:IPR017850" /db_xref="InterPro:IPR018299" /db_xref="SubtiList:BG10183" /db_xref="UniProtKB/Swiss-Prot:P19406" /translation="MKKMSLFQNMKSKLLPIAAVSVLTAGIFAGAELQQTEKASAKKQ DKAEIRNVIVMIGDGMGTPYIRAYRSMKNNGDTPNNPKLTEFDRNLTGMMMTHPDDPD YNITDSAAAGTALATGVKTYNNAIGVDKNGKKVKSVLEEAKQQGKSTGLVATSEINHA TPAAYGAHNESRKNMDQIANSYMDDKIKGKHKIDVLLGGGKSYFNRKDRNLTKEFKQA GYSYVTTKQALKKNKDQQVLGLFADGGLAKALDRDSKTPSLKDMTVSAIDRLNQNKKG FFLMVEGSQIDWAAHDNDTVGAMSEVKDFEQAYKAAIEFAKKDKHTLVIATADHTTGG FTIGANGEKNWHAEPILSAKKTPEFMAKKISEGKPVKDVLARYANLKVTSEEIKSVEA AAQADKSKGASKAIIKIFNTRSNSGWTSTDHTGEEVPVYAYGPGKEKFRGLINNTDQA NIIFKILKTGK*" /label="phoA CDS" gene complement(966660..968045) /gene="phoA" /locus_tag="BSU_09410" /old_locus_tag="BSU09410" /label="phoA gene" downshifts complement(966686) /Source="Nicolas_upshifts" /id="D491" /incds=0 /nref=51 /ntot=178 /MaxReadThrough="1.90638" /MaxDrop="5.795" /score="22.2126775" /energy="-13.2" /TU="NA" /idTUdmin="U742" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts complement(968072) /Source="Nicolas_upshifts" /id="U742" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.94105894105894" /psig="0.035964035964036" /xcortree=8 /SigmaFactorBS="acaaggctttacttattgtttacatgatcaacagccgcaTTT AACAAAGTTtccctaacatgataaacggaatacattaaaggaggcatgaaaaaaatga g" /listShort="phoA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(968074..969605) /Source="Nicolas_S_feature" /locus_tag="new_1018497_1020028_c" /HighExp="Etha, Salt, B60, Heat, M9-stat, T5.0H, T0.30H, T4.0H, T3.30H, T2.30H" /AntisenseName="lytE" /AntisenseCor="-0.65081062481616203" /AntisenseRegPval="-33.1" /CDS_PredictionProba="NA" /TUshortSig="SigWXY, SigA" /TUshortPSig="0.966, 0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S327" misc_feature complement(968082..968093) /Source="Nicolas_upshift_promotors" /id="U742" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.94105894105894" /psig="0.035964035964036" /xcortree=8 /SigmaFactorBS="acaaggctttacttattgtttacatgatcaacagccgcaTTT AACAAAGTTtccctaacatgataaacggaatacattaaaggaggcatgaaaaaaatga g" /listShort="phoA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-35 968201..968208 /Source="Nicolas_upshift_promotors" /id="U743" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.564435564435564" /psig="0.999000999001" /xcortree=3050 /SigmaFactorBS="ttatttgatgtaaagcattcatttttcagaaaaaTCTTTACC tctctgtctttgCATGATATGTTTGTTTAAATaaaaaaactgcggataaccacagctc t" /listShort="S328, lytE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 968221..968240 /Source="Nicolas_upshift_promotors" /id="U743" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.564435564435564" /psig="0.999000999001" /xcortree=3050 /SigmaFactorBS="ttatttgatgtaaagcattcatttttcagaaaaaTCTTTACC tctctgtctttgCATGATATGTTTGTTTAAATaaaaaaactgcggataaccacagctc t" /listShort="S328, lytE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 968227..968514 /Source="Nicolas_S_feature" /locus_tag="new_1018650_1018937" /HighExp="T-5.40H, Cold, LoTm, T-4.40H, UNK1, T5.0H, GM-0.1, T3.30H, S1, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S328" upshifts 968227 /Source="Nicolas_upshifts" /id="U743" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.564435564435564" /psig="0.999000999001" /xcortree=3050 /SigmaFactorBS="ttatttgatgtaaagcattcatttttcagaaaaaTCTTTACC tctctgtctttgCATGATATGTTTGTTTAAATaaaaaaactgcggataaccacagctc t" /listShort="S328, lytE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 968477..968480 /Source="Nicolas_upshift_promotors" /id="U744" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.75924075924076" /psig="0.971028971028971" /xcortree=3027 /SigmaFactorBS="atttgtcacatgaagtcaagaCTATttctgatgggaatcTAT CCTTATAATAGAAATCAataagattaatttaaaaaaagagatacatatatatagagtt a" /listShort="lytE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 968495..968514 /Source="Nicolas_upshift_promotors" /id="U744" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.75924075924076" /psig="0.971028971028971" /xcortree=3027 /SigmaFactorBS="atttgtcacatgaagtcaagaCTATttctgatgggaatcTAT CCTTATAATAGAAATCAataagattaatttaaaaaaagagatacatatatatagagtt a" /listShort="lytE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 968516 /Source="Nicolas_upshifts" /id="U744" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.75924075924076" /psig="0.971028971028971" /xcortree=3027 /SigmaFactorBS="atttgtcacatgaagtcaagaCTATttctgatgggaatcTAT CCTTATAATAGAAATCAataagattaatttaaaaaaagagatacatatatatagagtt a" /listShort="lytE" /GFF_Attribute="listLong" /label="upshifts" CDS 968575..969579 /gene="lytE" /locus_tag="BSU_09420" /old_locus_tag="BSU09420" /EC_number="3.4.-.-" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16855244, 16950129, 9457885, 21541672, 22139507, 27002131" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16855244, 16950129, 9457885, 21541672, 22139507, 27002131; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cell wall dl-endopeptidase; phosphatase-associated protein (major autolysin)" /protein_id="NP_388823.2" /db_xref="EnsemblGenomes-Gn:BSU09420" /db_xref="EnsemblGenomes-Tr:CAB12781" /db_xref="GOA:P54421" /db_xref="InterPro:IPR000064" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG11406" /db_xref="UniProtKB/Swiss-Prot:P54421" /translation="MKKQIITATTAVVLGSTLFAGAASAQSIKVKKGDTLWDLSRKYD TTISKIKSENHLRSDIIYVGQTLSINGKSTSSKSSSSSSSSSTYKVKSGDSLWKISKK YGMTINELKKLNGLKSDLLRVGQVLKLKGSTSSSSSSSSKVSSSSTSTYKVKSGDSLS KIASKYGTTVSKLKSLNGLKSDVIYVNQVLKVKGTSTSSSKPASSSSSSSSKTSSTSL NVSKLVSDAKALVGTPYKWGGTTTSGFDCSGFIWYVLNKQTSVGRTSTAGYWSSMKSI ASPSVGDFVFFTTYKSGPSHMGIYIGNNSFIHAGSDGVQISSLNNSYWKPRYLGAKRF *" /label="lytE CDS" gene 968575..969579 /gene="lytE" /locus_tag="BSU_09420" /old_locus_tag="BSU09420" /label="lytE gene" downshifts 969441 /Source="Nicolas_upshifts" /id="D492" /incds=1 /nref=1 /ntot=117 /MaxReadThrough="6.89938" /MaxDrop="2.1687" /score="26.3320532" /energy="-9.8" /TU="U743,U744" /idTUdmin="U743" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" downshifts 969571 /Source="Nicolas_upshifts" /id="D493" /incds=0 /nref=53 /ntot=190 /MaxReadThrough="3.64545" /MaxDrop="6.08377" /score="26.3320532" /energy="-9.8" /TU="U744" /idTUdmin="U743" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" upshifts complement(969605) /Source="Nicolas_upshifts" /id="U745" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=1640 /SigmaFactorBS="acattttcatttttaggAGCAACCAAAacgcctgtgctCCGT CTAATGAAAAAAacccgttccaatgaacgggttttctctaaaaattagaatcttttcg c" /listShort="S327, phoA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(969612..969627) /Source="Nicolas_upshift_promotors" /id="U745" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=1640 /SigmaFactorBS="acattttcatttttaggAGCAACCAAAacgcctgtgctCCGT CTAATGAAAAAAacccgttccaatgaacgggttttctctaaaaattagaatcttttcg c" /listShort="S327, phoA" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 969617 /Source="Nicolas_upshifts" /id="D494" /incds=0 /nref=1 /ntot=47 /MaxReadThrough="2.99" /MaxDrop="3.76174" /score="26.3320532" /energy="-9.8" /TU="U744" /idTUdmin="U743" /TUdmin=44 /isTUend="FALSE" /label="downshifts" promotor_-35 complement(969639..969648) /Source="Nicolas_upshift_promotors" /id="U745" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=1640 /SigmaFactorBS="acattttcatttttaggAGCAACCAAAacgcctgtgctCCGT CTAATGAAAAAAacccgttccaatgaacgggttttctctaaaaattagaatcttttcg c" /listShort="S327, phoA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(969650..970525) /gene="citR" /locus_tag="BSU_09430" /old_locus_tag="BSU09430" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8045899, 10869065" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045899, 10869065; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator CitR (LysR family)" /protein_id="NP_388824.2" /db_xref="EnsemblGenomes-Gn:BSU09430" /db_xref="EnsemblGenomes-Tr:CAB12782" /db_xref="GOA:P39127" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10853" /db_xref="UniProtKB/Swiss-Prot:P39127" /translation="MDFKWLHTFVTAAKYENFRKTAETLFLSQPTVTVHIKQLEKEIS CKLFERKGRQIQLTDEGRAYLPYALRLLDDYENSMAELHRVRQGYSQTLQLAVSPLIA DTVLPSVMKRYTAMNTETEMAVTIFESAEIASLIKAGEADIGLSCLKVQSSSLSCHCL YKDPVVLVAPPDKRFIEDNEIDAKEVLEQYLLLTHNHPDYWDDLLRQVRMTFPFVRTM KVTQTHITKRFIKEGLGVSFLPLSTVKRELAEKQMIRIPYQSVQLPYAGAYAIALYEN KKEKKFLDFLSHFHF*" /label="citR CDS" gene complement(969650..970525) /gene="citR" /locus_tag="BSU_09430" /old_locus_tag="BSU09430" /label="citR gene" promotor_-35 970578..970579 /Source="Nicolas_upshift_promotors" /id="U747" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.424575424575425" /psig="0.995004995004995" /xcortree=3081 /SigmaFactorBS="atatttttaattaattccctttaaaatattgaTTatttttta aatattatATTTACTATAATAACAGAAAaggatagggggaatacaaatggtacattac g" /listShort="citA, yhdF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(970591..970610) /Source="Nicolas_upshift_promotors" /id="U746" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.387612387612388" /psig="0.992007992007992" /xcortree=1894 /SigmaFactorBS="tccctttaatccgtaatgtaccatttgTATTCCccctatcct tttctGTTATTATAGTAAATATAATatttaaaaaataatcaatattttaaagggaatt a" /listShort="citR, S327" /listLong="phoA" /label="promotor_-10" promotor_-10 970596..970615 /Source="Nicolas_upshift_promotors" /id="U747" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.424575424575425" /psig="0.995004995004995" /xcortree=3081 /SigmaFactorBS="atatttttaattaattccctttaaaatattgaTTatttttta aatattatATTTACTATAATAACAGAAAaggatagggggaatacaaatggtacattac g" /listShort="citA, yhdF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(970597) /Source="Nicolas_upshifts" /id="U746" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.387612387612388" /psig="0.992007992007992" /xcortree=1894 /SigmaFactorBS="tccctttaatccgtaatgtaccatttgTATTCCccctatcct tttctGTTATTATAGTAAATATAATatttaaaaaataatcaatattttaaagggaatt a" /listShort="citR, S327" /listLong="phoA" /label="upshifts" upshifts 970606 /Source="Nicolas_upshifts" /id="U747" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.424575424575425" /psig="0.995004995004995" /xcortree=3081 /SigmaFactorBS="atatttttaattaattccctttaaaatattgaTTatttttta aatattatATTTACTATAATAACAGAAAaggatagggggaatacaaatggtacattac g" /listShort="citA, yhdF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(970625..970630) /Source="Nicolas_upshift_promotors" /id="U746" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.387612387612388" /psig="0.992007992007992" /xcortree=1894 /SigmaFactorBS="tccctttaatccgtaatgtaccatttgTATTCCccctatcct tttctGTTATTATAGTAAATATAATatttaaaaaataatcaatattttaaagggaatt a" /listShort="citR, S327" /listLong="phoA" /label="promotor_-35" CDS 970634..971734 /gene="citA" /locus_tag="BSU_09440" /old_locus_tag="BSU09440" /EC_number="2.3.3.16" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:4211224, 8045898, 8045899" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4211224, 8045898, 8045899; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="citrate synthase I" /protein_id="NP_388825.2" /db_xref="EnsemblGenomes-Gn:BSU09440" /db_xref="EnsemblGenomes-Tr:CAB12783" /db_xref="GOA:P39119" /db_xref="InterPro:IPR002020" /db_xref="InterPro:IPR016142" /db_xref="InterPro:IPR016143" /db_xref="InterPro:IPR019810" /db_xref="InterPro:IPR024176" /db_xref="InterPro:IPR036969" /db_xref="PDB:2C6X" /db_xref="SubtiList:BG10854" /db_xref="UniProtKB/Swiss-Prot:P39119" /translation="MVHYGLKGITCVETSISHIDGEKGRLIYRGHHAKDIALNHSFEE AAYLILFGKLPSTEELQVFKDKLAAERNLPEHIERLIQSLPNNMDDMSVLRTVVSALG ENTYTFHPKTEEAIRLIAITPSIIAYRKRWTRGEQAIAPSSQYGHVENYYYMLTGEQP SEAKKKALETYMILATEHGMNASTFSARVTLSTESDLVSAVTAALGTMKGPLHGGAPS AVTKMLEDIGEKEHAEAYLKEKLEKGERLMGFGHRVYKTKDPRAEALRQKAEEVAGND RDLDLALHVEAEAIRLLEIYKPGRKLYTNVEFYAAAVMRAIDFDDELFTPTFSASRMV GWCAHVLEQAENNMIFRPSAQYTGAIPEEVLS*" /label="citA CDS" gene 970634..971734 /gene="citA" /locus_tag="BSU_09440" /old_locus_tag="BSU09440" /label="citA gene" promotor_-35 971745..971751 /Source="Nicolas_upshift_promotors" /id="U748" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=256 /SigmaFactorBS="attcccgaggaagttctttcataacatattttggCGTTTATt catttctgtcgtgTGGTAACGTTCAGTATCAAccacatgtctaggagtgatgaatgtg a" /listShort="yhdF, S329, ctrA, yhdH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 971766..971784 /Source="Nicolas_upshift_promotors" /id="U748" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=256 /SigmaFactorBS="attcccgaggaagttctttcataacatattttggCGTTTATt catttctgtcgtgTGGTAACGTTCAGTATCAAccacatgtctaggagtgatgaatgtg a" /listShort="yhdF, S329, ctrA, yhdH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 971771 /Source="Nicolas_upshifts" /id="U748" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=256 /SigmaFactorBS="attcccgaggaagttctttcataacatattttggCGTTTATt catttctgtcgtgTGGTAACGTTCAGTATCAAccacatgtctaggagtgatgaatgtg a" /listShort="yhdF, S329, ctrA, yhdH" /GFF_Attribute="listLong" /label="upshifts" CDS 971808..972677 /gene="yhdF" /locus_tag="BSU_09450" /old_locus_tag="BSU09450" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10482513, 18643936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NAD(P)-dependent dehydrogenase" /protein_id="NP_388826.1" /db_xref="EnsemblGenomes-Gn:BSU09450" /db_xref="EnsemblGenomes-Tr:CAB12784" /db_xref="GOA:O07575" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13012" /db_xref="UniProtKB/Swiss-Prot:O07575" /translation="MNPMDRQTEGQEPQHQDRQPGIESKMNPLPLSEDEDYRGSGKLK GKVAIITGGDSGIGRAAAIAFAKEGADISILYLDEHSDAEETRKRIEKENVRCLLIPG DVGDENHCEQAVQQTVDHFGKLDILVNNAAEQHPQDSILNISTEQLEKTFRTNIFSMF HMTKKALPHLQEGCAIINTTSITAYEGDTALIDYSSTKGAIVSFTRSMAKSLADKGIR VNAVAPGPIWTPLIPATFPEEKVKQHGLDTPMGRPGQPVEHAGAYVLLASDESSYMTG QTIHVNGGRFIST*" /label="yhdF CDS" gene 971808..972677 /gene="yhdF" /locus_tag="BSU_09450" /old_locus_tag="BSU09450" /label="yhdF gene" downshifts 972685 /Source="Nicolas_upshifts" /id="D495" /incds=0 /nref=27 /ntot=130 /MaxReadThrough="8.65426" /MaxDrop="6.48064" /score="18.1511963" /energy="-8.2" /TU="U748" /idTUdmin="U747" /TUdmin=9 /isTUend="TRUE" /label="downshifts" promotor_-35 972762..972765 /Source="Nicolas_upshift_promotors" /id="U749" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.597402597402597" /psig="0.998001998001998" /xcortree=2903 /SigmaFactorBS="tgaaaaatttcaaaataaaaaatttgtcgatttttctaacaa tttTGTTttcatttttgcaatTTTATATATAATATTGAGTAggagaaaggaatgattc g" /listShort="S329, ctrA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 972777 /Source="Nicolas_upshifts" /id="U749" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.597402597402597" /psig="0.998001998001998" /xcortree=2903 /SigmaFactorBS="tgaaaaatttcaaaataaaaaatttgtcgatttttctaacaa tttTGTTttcatttttgcaatTTTATATATAATATTGAGTAggagaaaggaatgattc g" /listShort="S329, ctrA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 972780..972799 /Source="Nicolas_upshift_promotors" /id="U749" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.597402597402597" /psig="0.998001998001998" /xcortree=2903 /SigmaFactorBS="tgaaaaatttcaaaataaaaaatttgtcgatttttctaacaa tttTGTTttcatttttgcaatTTTATATATAATATTGAGTAggagaaaggaatgattc g" /listShort="S329, ctrA" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature 972825..972844 /Source="Nicolas_upshift_promotors" /id="U750" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.509490509490509" /psig="0.522477522477522" /xcortree=652 /SigmaFactorBS="tttttgcaattttatatataatattgagtaggagaaaggaat gattcgcgaccagTACAAATATAGTAGAAAAAAaagaataatgaccattgttactcat g" /listShort="S329, ctrA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 972830..972926 /Source="Nicolas_S_feature" /locus_tag="new_1023253_1023349" /HighExp="Etha, T2.30H, T-0.40H, T2.0H, T1.30H, S1, GM-0.2, T3.0H, T-1.40H, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.27332800000000002" /TUshortSig="SigA, SigA, SigB" /TUshortPSig="0.522, 0.998, 0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S329" upshifts 972830 /Source="Nicolas_upshifts" /id="U750" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.509490509490509" /psig="0.522477522477522" /xcortree=652 /SigmaFactorBS="tttttgcaattttatatataatattgagtaggagaaaggaat gattcgcgaccagTACAAATATAGTAGAAAAAAaagaataatgaccattgttactcat g" /listShort="S329, ctrA" /GFF_Attribute="listLong" /label="upshifts" CDS 972927..974324 /gene="bcaP" /locus_tag="BSU_09460" /old_locus_tag="BSU09460" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16621821, 16850406, 21097623, 25645558" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16621821, 16850406, 21097623, 25645558; Product type t : transporter" /codon_start=1 /transl_table=11 /product="branched-chain amino acid transporter or methylthioribose-degradation metabolite exporter" /protein_id="NP_388827.1" /db_xref="EnsemblGenomes-Gn:BSU09460" /db_xref="EnsemblGenomes-Tr:CAB12785" /db_xref="GOA:O07576" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004758" /db_xref="SubtiList:BG13013" /db_xref="UniProtKB/Swiss-Prot:O07576" /translation="MKGSVFRKKSIQDLIAATSGEKSLKRELGAFDLTLLGIGAIIGT GIFVLTGTGAVTAGPGLTISFVVAALACLFAALSYAEFASSVPVSGSVYTFTYATLGE LMAFIIGWDLILEYMLAVSAVSVGWSGYFQSFLSGLGIHLPVALTAAPGAVKGTFTLF NLPAFVIVMAITYLLYLGIKESKRVNNIMVILKILVVLLFIAVAAVYVKPHNWQPFMP MGFGGVFSAAALVFFAFIGFDAVSSAAEETKNPAKDLPKGIIFSLLVCTILYVTVSAI MTGVIPFAQFAGVDHPVSLVLQSAGQNWVAGIIDIGAVLGMTTVMLVMLYGQTRVMFA MSRDGLVPGSLSKVHPKHKTPYVATWFFGTMSALLGSLVPLDELAKLVNIGTLSAFVL ISVAVIVLRKKQPDLPRAFKCPGVPVIPGLAILFCLFLILNLGWVTIVRFLVWLLIGL VIYFLYSRKHSKLNQ*" /label="bcaP CDS" gene 972927..974324 /gene="bcaP" /locus_tag="BSU_09460" /old_locus_tag="BSU09460" /label="bcaP gene" downshifts 974304 /Source="Nicolas_upshifts" /id="D496" /incds=0 /nref=116 /ntot=188 /MaxReadThrough="3.41176" /MaxDrop="5.29633" /score="5.08283681" /energy="-12.3" /TU="U748,U749" /idTUdmin="U750" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 974385..974389 /Source="Nicolas_upshift_promotors" /id="U751" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.914085914085914" /psig=1 /xcortree=2512 /SigmaFactorBS="ggccgcctcttttctgttcttggcaaatgaatcTATAGaaat gaagacaaaaaTAAGAGATAATATAGGCTGGaaaggaagtgacgtttattgtctgagc a" /listShort="yhdH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 974405..974424 /Source="Nicolas_upshift_promotors" /id="U751" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.914085914085914" /psig=1 /xcortree=2512 /SigmaFactorBS="ggccgcctcttttctgttcttggcaaatgaatcTATAGaaat gaagacaaaaaTAAGAGATAATATAGGCTGGaaaggaagtgacgtttattgtctgagc a" /listShort="yhdH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 974412 /Source="Nicolas_upshifts" /id="U751" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.914085914085914" /psig=1 /xcortree=2512 /SigmaFactorBS="ggccgcctcttttctgttcttggcaaatgaatcTATAGaaat gaagacaaaaaTAAGAGATAATATAGGCTGGaaaggaagtgacgtttattgtctgagc a" /listShort="yhdH" /GFF_Attribute="listLong" /label="upshifts" CDS 974442..975797 /gene="yhdH" /locus_tag="BSU_09470" /old_locus_tag="BSU09470" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 17114254; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative sodium-dependent transporter" /protein_id="NP_388828.1" /db_xref="EnsemblGenomes-Gn:BSU09470" /db_xref="EnsemblGenomes-Tr:CAB12786" /db_xref="GOA:O07577" /db_xref="InterPro:IPR000175" /db_xref="SubtiList:BG13014" /db_xref="UniProtKB/Swiss-Prot:O07577" /translation="MSEQKPVQWASKIGFVMAAAGSAIGLGAIWKFPYVAGTNGGGAF FLIFVLFTILLGYPLLVGEFIFGRRNQTNAIDAYKKEAPRSAWFLTGWIGVAACFLVL SFYSVIGGWILLYIVKTASGSLSGLSQAQYGALFASIIQNPVQTLAAQLVFMALTVLV VARGVQKGIERVSAVMMPILFLLFILLVLRSLTLNGAMEGVKFLLVPHFGDLTPESIL FALGQAFFTLTLGVSVMVTYSSYLPKTQNIPRSAASIVLMNIIVTLLAGLAIFPAVFS FGFQPNEGPTLLFTVLPAVFEQLPFGTLFFIGFLVAFLFAALTSAFSMVEIIVATIGK GDEKKRKKLSWTSGLLIFLVGIPCCLSYGVLSDVHLFGKTFFDIADFTVSNVLMPSGA LLISLFIPLKISKSELLAEMRNGSNAGKAFFYTWFYLLRFIVPLAIIIVFLNLIGILS F*" /label="yhdH CDS" gene 974442..975797 /gene="yhdH" /locus_tag="BSU_09470" /old_locus_tag="BSU09470" /label="yhdH gene" downshifts 975778 /Source="Nicolas_upshifts" /id="D497" /incds=0 /nref=184 /ntot=244 /MaxReadThrough="1.73756" /MaxDrop="6.09379" /score="40.1809389" /energy="-14.8" /TU="NA" /idTUdmin="U751" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(975832..977241) /gene="yhdI" /locus_tag="BSU_09480" /old_locus_tag="BSU09480" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15223311; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative PLP-dependent transcriptional regulator" /protein_id="NP_388829.1" /db_xref="EnsemblGenomes-Gn:BSU09480" /db_xref="EnsemblGenomes-Tr:CAB12787" /db_xref="GOA:O07578" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13015" /db_xref="UniProtKB/Swiss-Prot:O07578" /translation="MDITPFLDKKSKTPLYEQLYTFFKQEISHARITKGTRLPSKRRL SSLLDVSTATIERAYEQLTAEGYVKSKPKIGWFAAEVEPGFPTAPDHFQQSVQPGLHQ KNAPAIDFHQGSVDPTLFPFNAWRKSIVKSLDRYSGSFHTSGDPQGEYELRHMIARFV RLSRGVNCEPGQIIIGAGTTVLLQNLCLSLKPGTKIGFEEPGFHRSRRMFEANHMDVT PICSDAEGVLPDELYRQNPYLMYTTPSHQFPIGTIMTITRRQELLAWAAETNSFIIED DYDGEFRYSGHPIPSLQGLDPNGRVIYLGTFSKSLLPSLRLSFMIVPPELMEPIQNNV QLMKQTVSAHSQLALADFIETGEWQKHINRMRSLYRKKHAVLLEAIRSELGNTVEILG KNSGLHILLRLLFPASEEEAIQAAADHGVTLYPVSPSYIEQTPFTSVLIGYGGLSEED IRLGIQKLKTAWAPLISSY*" /label="yhdI CDS" gene complement(975832..977241) /gene="yhdI" /locus_tag="BSU_09480" /old_locus_tag="BSU09480" /label="yhdI gene" promotor_-35 977290..977293 /Source="Nicolas_upshift_promotors" /id="U752" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.52047952047952" /psig="0.996003996003996" /xcortree=459 /SigmaFactorBS="tcctttgtagctggcatggtcattttttctgatattggctAT TTggcaaatgccatttATTAGCTATGATCATTGTAAcgaaaggaaaggggattgagaa g" /listShort="yhdJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 977308..977327 /Source="Nicolas_upshift_promotors" /id="U752" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.52047952047952" /psig="0.996003996003996" /xcortree=459 /SigmaFactorBS="tcctttgtagctggcatggtcattttttctgatattggctAT TTggcaaatgccatttATTAGCTATGATCATTGTAAcgaaaggaaaggggattgagaa g" /listShort="yhdJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 977310 /Source="Nicolas_upshifts" /id="U752" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.52047952047952" /psig="0.996003996003996" /xcortree=459 /SigmaFactorBS="tcctttgtagctggcatggtcattttttctgatattggctAT TTggcaaatgccatttATTAGCTATGATCATTGTAAcgaaaggaaaggggattgagaa g" /listShort="yhdJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(977312..977331) /Source="Nicolas_upshift_promotors" /id="U753" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=2744 /SigmaFactorBS="cttctttcgaggttaattgtttcatatggatcaTCTTCtcaa tcccctttcctTTCGTTACAATGATCATAGCtaataaatggcatttgccaaatagcca a" /listShort="yhdI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(977324) /Source="Nicolas_upshifts" /id="U753" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=2744 /SigmaFactorBS="cttctttcgaggttaattgtttcatatggatcaTCTTCtcaa tcccctttcctTTCGTTACAATGATCATAGCtaataaatggcatttgccaaatagcca a" /listShort="yhdI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(977347..977351) /Source="Nicolas_upshift_promotors" /id="U753" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=2744 /SigmaFactorBS="cttctttcgaggttaattgtttcatatggatcaTCTTCtcaa tcccctttcctTTCGTTACAATGATCATAGCtaataaatggcatttgccaaatagcca a" /listShort="yhdI" /GFF_Attribute="listLong" /label="promotor_-35" CDS 977351..977779 /gene="yhdJ" /locus_tag="BSU_09490" /old_locus_tag="BSU09490" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12793527; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_388830.1" /db_xref="EnsemblGenomes-Gn:BSU09490" /db_xref="EnsemblGenomes-Tr:CAB12788" /db_xref="GOA:O07579" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13016" /db_xref="UniProtKB/Swiss-Prot:O07579" /translation="MIHMKQLTSKEEWAESYPIMSELRTELDIETYLQRLEACVQKES YMLFALYENTAIRALCGALPRVSIHKGEHLWIADLVTTAPCRSKGYGKMLLDYASDWA RKAGLGFVSLSSGLQRKDAHRFYTDKMGFTIESYLFRKPV*" /label="yhdJ CDS" gene 977351..977779 /gene="yhdJ" /locus_tag="BSU_09490" /old_locus_tag="BSU09490" /label="yhdJ gene" downshifts 977758 /Source="Nicolas_upshifts" /id="D498" /incds=0 /nref=46 /ntot=213 /MaxReadThrough="1.42962" /MaxDrop="4.77191" /score="24.6412105" /energy="-12.1" /TU="NA" /idTUdmin="U752" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(977810..978100) /gene="asiMB" /locus_tag="BSU_09500" /old_locus_tag="BSU09500" /experiment="publication(s) with functional evidences, PMID:10216858" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10216858; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative regulator of the activity of sigma-M" /protein_id="NP_388831.1" /db_xref="EnsemblGenomes-Gn:BSU09500" /db_xref="EnsemblGenomes-Tr:CAB12789" /db_xref="GOA:O07580" /db_xref="InterPro:IPR020496" /db_xref="SubtiList:BG13017" /db_xref="UniProtKB/Swiss-Prot:O07580" /translation="MELVRIFKEHNVFGWISVGTAVLSLLLLNLAIISNVTFYSYQML PFAMAAVPFGVVELFIKRGRTGPGLLGVILNLFVIICVYTIVSVDTNLQFGF*" /label="asiMB CDS" gene complement(977810..978100) /gene="asiMB" /locus_tag="BSU_09500" /old_locus_tag="BSU09500" /label="asiMB gene" downshifts complement(977834) /Source="Nicolas_upshifts" /id="D499" /incds=0 /nref=44 /ntot=229 /MaxReadThrough="2.66153" /MaxDrop="4.72865" /score="26.7359231" /energy="-11.1" /TU="NA" /idTUdmin="U754" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(978088..979164) /gene="asiMA" /locus_tag="BSU_09510" /old_locus_tag="BSU09510" /experiment="publication(s) with functional evidences, PMID:10216858" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10216858; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative regulator of the activity of sigma-M" /protein_id="NP_388832.1" /db_xref="EnsemblGenomes-Gn:BSU09510" /db_xref="EnsemblGenomes-Tr:CAB12790" /db_xref="GOA:O07581" /db_xref="InterPro:IPR025672" /db_xref="InterPro:IPR029101" /db_xref="SubtiList:BG13018" /db_xref="UniProtKB/Swiss-Prot:O07581" /translation="MMNEEFKKRFDQYKNGEMSDQEMTAFEEELEKLEVYQELIDSEL EDDNDWDLSISPEKQKAILAYGKRKSYLRISVLAVISTLMILPLCTLGSYLYYGMGGK HSTGNEFMETAAVTVALTMPNVLVDTSGLKSQVKLFGMNTEFPLQKQIGTKTAAVGNE RVEMFYNKVKAPAVNYYDLEVNKTGHYFTHPSNKSEQTTAKAEKTLSTLPEGTVSEVY LSYDRAYPTKDVYNKFKGYDVSFLWNAIETEKNTNKTASTEPLGYPGKDSKFLAALNT KGKSNGDQFINALKFMSKHEKWAQVISKRKDLNVDNRLDYVEKNGVNVYGSVVTGPTK EIQRMLKNKSVKSANVGEVELWNW*" /label="asiMA CDS" gene complement(978088..979164) /gene="asiMA" /locus_tag="BSU_09510" /old_locus_tag="BSU09510" /label="asiMA gene" CDS complement(979154..979645) /gene="sigM" /locus_tag="BSU_09520" /old_locus_tag="BSU09520" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14651641, 14769884" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14651641, 14769884; Product type r: regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase ECF (extracytoplasmic function)-type sigma factor (sigma(M))" /protein_id="NP_388833.1" /db_xref="EnsemblGenomes-Gn:BSU09520" /db_xref="EnsemblGenomes-Tr:CAB12791" /db_xref="GOA:O07582" /db_xref="InterPro:IPR000838" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013249" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR014296" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG13019" /db_xref="UniProtKB/Swiss-Prot:O07582" /translation="MTIDEIYQMYMNDVYRFLLSMTKDKHLAEDLLQETFMRAYIHIH SYDHSKVKPWLFQVARNAFIDYVRKHKKEVTISDDLIGSLFQNAVQSPAHQVEIKEVL TGYMSELPDNYREALTLYYLKELNYKEASHIMNISEANFKSVLFRARQRLKALYNRGV NDE*" /label="sigM CDS" gene complement(979154..979645) /gene="sigM" /locus_tag="BSU_09520" /old_locus_tag="BSU09520" /label="sigM gene" S_feature complement(979646..979748) /Source="Nicolas_S_feature" /locus_tag="new_1030069_1030171_c" /HighExp="Cold, LBGstat, H2O2, G180, Paraq, Oxctl, G135, HPh, dia15, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S330" promotor_-10 complement(979737..979756) /Source="Nicolas_upshift_promotors" /id="U754" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.826173826173826" /psig=1 /xcortree=2579 /SigmaFactorBS="ccctctggaaaaaatgttaaacctttctccgcactATCTttt gcggccatttTTGGGTACTATATAGTAATGgtgtttgattaggtataaaaaagccgtt t" /listShort="S330, sigM, yhdL, yhdK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(979748) /Source="Nicolas_upshifts" /id="U754" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.826173826173826" /psig=1 /xcortree=2579 /SigmaFactorBS="ccctctggaaaaaatgttaaacctttctccgcactATCTttt gcggccatttTTGGGTACTATATAGTAATGgtgtttgattaggtataaaaaagccgtt t" /listShort="S330, sigM, yhdL, yhdK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(979770..979773) /Source="Nicolas_upshift_promotors" /id="U754" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.826173826173826" /psig=1 /xcortree=2579 /SigmaFactorBS="ccctctggaaaaaatgttaaacctttctccgcactATCTttt gcggccatttTTGGGTACTATATAGTAATGgtgtttgattaggtataaaaaagccgtt t" /listShort="S330, sigM, yhdL, yhdK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 979786..979792 /Source="Nicolas_upshift_promotors" /id="U755" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=224 /SigmaFactorBS="tatatagtacccaaaaatggccgcaaaagatagtgcggagaa aGGTTTAAcattttttccagagGGGAAAAGATAGTGAAAAAgtgaaggagtggcacaa t" /listShort="yhdN, plsC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 979803 /Source="Nicolas_upshifts" /id="U755" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=224 /SigmaFactorBS="tatatagtacccaaaaatggccgcaaaagatagtgcggagaa aGGTTTAAcattttttccagagGGGAAAAGATAGTGAAAAAgtgaaggagtggcacaa t" /listShort="yhdN, plsC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 979807..979825 /Source="Nicolas_upshift_promotors" /id="U755" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=224 /SigmaFactorBS="tatatagtacccaaaaatggccgcaaaagatagtgcggagaa aGGTTTAAcattttttccagagGGGAAAAGATAGTGAAAAAgtgaaggagtggcacaa t" /listShort="yhdN, plsC" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(979836) /Source="Nicolas_upshifts" /id="D500" /incds=0 /nref=2 /ntot=13 /MaxReadThrough="2.13683" /MaxDrop="4.59517" /score="8.96845329" /energy="-10.2" /TU="NA" /idTUdmin="U757" /TUdmin=1804 /isTUend="FALSE" /label="downshifts" CDS 979842..980837 /gene="akrN" /locus_tag="BSU_09530" /old_locus_tag="BSU09530" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10220166, 15019785, 24330391" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10220166, 15019785, 24330391; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aldo/keto reductase specific for NADPH; protectsagainst methylglyoxal" /protein_id="NP_388834.1" /db_xref="EnsemblGenomes-Gn:BSU09530" /db_xref="EnsemblGenomes-Tr:CAB12792" /db_xref="GOA:P80874" /db_xref="InterPro:IPR018170" /db_xref="InterPro:IPR020471" /db_xref="InterPro:IPR023210" /db_xref="InterPro:IPR036812" /db_xref="PDB:1PZ1" /db_xref="SubtiList:BG13020" /db_xref="UniProtKB/Swiss-Prot:P80874" /translation="MEYTSIADTGIEASRIGLGTWAIGGTMWGGTDEKTSIETIRAAL DQGITLIDTAPAYGFGQSEEIVGKAIKEYGKRDQVILATKTALDWKNNQLFRHANRAR IVEEVENSLKRLQTDYIDLYQVHWPDPLVPIEETAEVMKELYDAGKIRAIGVSNFSIE QMDTFRAVAPLHTIQPPYNLFEREMEESVLPYAKDNKITTLLYGSLCRGLLTGKMTEE YTFEGDDLRNHDPKFQKPRFKEYLSAVNQLDKLAKTRYGKSVIHLAVRWILDQPGADI ALWGARKPGQLEALSEITGWTLNSEDQKDINTILENTISDPVGPEFMAPPTREEI*" /label="akrN CDS" gene 979842..980837 /gene="akrN" /locus_tag="BSU_09530" /old_locus_tag="BSU09530" /label="akrN gene" downshifts 980816 /Source="Nicolas_upshifts" /id="D501" /incds=0 /nref=59 /ntot=160 /MaxReadThrough="6.85446" /MaxDrop="4.90106" /score="10.4379759" /energy="-11.8" /TU="U755" /idTUdmin="U756" /TUdmin="-770" /isTUend="FALSE" /label="downshifts" promotor_-35 980899..980902 /Source="Nicolas_upshift_promotors" /id="U756" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.537462537462537" /psig=1 /xcortree=2186 /SigmaFactorBS="ctttttggcgtttaaacgagagaaatcttaaaaattaGTACc aggtaataaaaaaTATTGTTATAATAGATGACAgaaagaatcattgattacgacaaag g" /listShort="plsC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 980917..980936 /Source="Nicolas_upshift_promotors" /id="U756" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.537462537462537" /psig=1 /xcortree=2186 /SigmaFactorBS="ctttttggcgtttaaacgagagaaatcttaaaaattaGTACc aggtaataaaaaaTATTGTTATAATAGATGACAgaaagaatcattgattacgacaaag g" /listShort="plsC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 980922 /Source="Nicolas_upshifts" /id="U756" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.537462537462537" /psig=1 /xcortree=2186 /SigmaFactorBS="ctttttggcgtttaaacgagagaaatcttaaaaattaGTACc aggtaataaaaaaTATTGTTATAATAGATGACAgaaagaatcattgattacgacaaag g" /listShort="plsC" /GFF_Attribute="listLong" /label="upshifts" CDS 980972..981571 /gene="plsC" /locus_tag="BSU_09540" /old_locus_tag="BSU09540" /EC_number="2.3.1.51" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 1557036, 17557823" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 1557036, 17557823; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="1-acylglycerol-phosphate (1-acyl-G3P) acyltransferase" /protein_id="NP_388835.1" /db_xref="EnsemblGenomes-Gn:BSU09540" /db_xref="EnsemblGenomes-Tr:CAB12793" /db_xref="GOA:O07584" /db_xref="InterPro:IPR002123" /db_xref="InterPro:IPR004552" /db_xref="SubtiList:BG13021" /db_xref="UniProtKB/Swiss-Prot:O07584" /translation="MYKFCANALKVILSLRGGVKVYNKENLPADSGFVIACTHSGWVD VITLGVGILPYQIHYMAKKELFQNKWIGSFLKKIHAFPVDRENPGPSSIKTPIKLLKE GEIVGIFPSGTRTSEDVPLKRGAVTIAQMGKAPLVPAAYQGPSSGKELFKKGKMKLII GEPLHQADFAHLPSKERLAAMTEALNQRIKELENKLDQL*" /label="plsC CDS" gene 980972..981571 /gene="plsC" /locus_tag="BSU_09540" /old_locus_tag="BSU09540" /label="plsC gene" downshifts 981586 /Source="Nicolas_upshifts" /id="D502" /incds=0 /nref=189 /ntot=245 /MaxReadThrough="6.36101" /MaxDrop="7.07164" /score="-7.3088084" /energy="-6.1" /TU="U755" /idTUdmin="U756" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 981631..983585 /Source="Nicolas_S_feature" /locus_tag="new_1032054_1034008" /HighExp="Cold, C30, S8, T-4.40H, Sw, Fru, S0, S7, HPh, G135" /AntisenseName="yhdP" /AntisenseCor="-0.46228251493795502" /AntisenseRegPval="-14.9" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S331" CDS complement(981640..982974) /gene="yhdP" /locus_tag="BSU_09550" /old_locus_tag="BSU09550" /function="16.1: Circulate" /function="16.12: Sense" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10960106, 25182490; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative magnesium efflux pump" /protein_id="NP_388836.1" /db_xref="EnsemblGenomes-Gn:BSU09550" /db_xref="EnsemblGenomes-Tr:CAB12794" /db_xref="GOA:O07585" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR002550" /db_xref="InterPro:IPR005170" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR036318" /db_xref="SubtiList:BG13022" /db_xref="UniProtKB/Swiss-Prot:O07585" /translation="MDIVNLILVAVLIALTAFFVASEFAIIRIRGSRIDQLIAEGNKA AIAVKKVTTHLDEYLSACQLGITLTSIGLGVLGESTIERLLHPLFVQMNVPGSLSHVI SFIFAYAIITFLHVVVGELAPKTVAIQKAEAVSMLFAKPLIWFYRIAFPFIWLLNNSA RLLTKAFGLETVSENELAHSEEELRIILSESYKSGEINQSEFKYVNKIFEFDDRLAKE IMIPRTEIVSLPHDIKISEMMDIIQIEKYTRYPVEEGDKDNIIGVINIKEVLTACISG EVSVDSTISQFVNPIIHVIESAPIQDLLVKMQKERVHMAILSDEYGGTAGLVTVEDII EEIVGEIRDEFDIDEISEIRKIGEGHYILDGKVLIDQVNDLLGIHLENEEVDTIGGWF LTQKYDVEKDDSIIEEGCEFIINEIDGHHVAYIEVKKLQEEELLETANQQEA*" /label="yhdP CDS" gene complement(981640..982974) /gene="yhdP" /locus_tag="BSU_09550" /old_locus_tag="BSU09550" /label="yhdP gene" downshifts complement(981659) /Source="Nicolas_upshifts" /id="D503" /incds=0 /nref=284 /ntot=315 /MaxReadThrough="1.96991" /MaxDrop="7.22379" /score="11.1466394" /energy="-9.1" /TU="NA" /idTUdmin="U757" /TUdmin="-19" /isTUend="TRUE" /label="downshifts" CDS complement(983035..983466) /gene="cueR" /locus_tag="BSU_09560" /old_locus_tag="BSU09560" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14663075, 18048925" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14663075, 18048925; Product type r: regulator" /codon_start=1 /transl_table=11 /product="indirect copper efflux transcriptional regulator" /protein_id="NP_388837.1" /db_xref="EnsemblGenomes-Gn:BSU09560" /db_xref="EnsemblGenomes-Tr:CAB12795" /db_xref="GOA:O07586" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="SubtiList:BG13023" /db_xref="UniProtKB/Swiss-Prot:O07586" /translation="MVGRDIDGAETYRISELAALAGVTKRTVDYYTNLGLLTPARSCS NYRYYDENALKRLIFIVDCKKQRLALSDIKDRLENQFPSSAKLDDEIGNLALEIDHMN QNISGILHRFERLKPEDRDKLKSKLPPEKLAVFQSFMLLLS*" /label="cueR CDS" gene complement(983035..983466) /gene="cueR" /locus_tag="BSU_09560" /old_locus_tag="BSU09560" /label="cueR gene" promotor_-10 complement(983478..983497) /Source="Nicolas_upshift_promotors" /id="U757" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.410589410589411" /psig="0.965034965034965" /xcortree=2994 /SigmaFactorBS="cttccaattccggtctaaaaaaaacaataaACTTGTGcaaga caccgttcaTATATTAAACTATTCTCATAactataacgtgatggttgggagggatata g" /listShort="cueR, yhdP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(983488) /Source="Nicolas_upshifts" /id="U757" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.410589410589411" /psig="0.965034965034965" /xcortree=2994 /SigmaFactorBS="cttccaattccggtctaaaaaaaacaataaACTTGTGcaaga caccgttcaTATATTAAACTATTCTCATAactataacgtgatggttgggagggatata g" /listShort="cueR, yhdP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(983512..983518) /Source="Nicolas_upshift_promotors" /id="U757" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.410589410589411" /psig="0.965034965034965" /xcortree=2994 /SigmaFactorBS="cttccaattccggtctaaaaaaaacaataaACTTGTGcaaga caccgttcaTATATTAAACTATTCTCATAactataacgtgatggttgggagggatata g" /listShort="cueR, yhdP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_no_box complement(983514..983614) /Source="Nicolas_upshift_promotors" /id="U758" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.708291708291708" /psig="0.006993006993007" /xcortree=284 /SigmaFactorBS="tccgcatataaaaatttgaaaattctatcttcctatgttact tcaatcagatgatgaattccacaacttccaattccggtctaaaaaaaacaataaactt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-35 983549..983556 /Source="Nicolas_upshift_promotors" /id="U759" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.616383616383616" /psig="0.996003996003996" /xcortree=3066 /SigmaFactorBS="ttttttagaccggaattggaagTTGTGGAAttcatcatctga tTGAAGTAACATAGGAAGATAgaattttcaaatttttatatgcggaagggacagatga a" /listShort="yhdR, S332" /listLong="S333, yhdT" /label="promotor_-35" upshifts complement(983554) /Source="Nicolas_upshifts" /id="U758" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.708291708291708" /psig="0.006993006993007" /xcortree=284 /SigmaFactorBS="tccgcatataaaaatttgaaaattctatcttcctatgttact tcaatcagatgatgaattccacaacttccaattccggtctaaaaaaaacaataaactt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 983570..983589 /Source="Nicolas_upshift_promotors" /id="U759" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.616383616383616" /psig="0.996003996003996" /xcortree=3066 /SigmaFactorBS="ttttttagaccggaattggaagTTGTGGAAttcatcatctga tTGAAGTAACATAGGAAGATAgaattttcaaatttttatatgcggaagggacagatga a" /listShort="yhdR, S332" /listLong="S333, yhdT" /label="promotor_-10" upshifts 983587 /Source="Nicolas_upshifts" /id="U759" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.616383616383616" /psig="0.996003996003996" /xcortree=3066 /SigmaFactorBS="ttttttagaccggaattggaagTTGTGGAAttcatcatctga tTGAAGTAACATAGGAAGATAgaattttcaaatttttatatgcggaagggacagatga a" /listShort="yhdR, S332" /listLong="S333, yhdT" /label="upshifts" CDS 983623..984804 /gene="yhdR" /locus_tag="BSU_09570" /old_locus_tag="BSU09570" /EC_number="2.6.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12670965, 15103638; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aspartate aminotransferase" /protein_id="NP_388838.1" /db_xref="EnsemblGenomes-Gn:BSU09570" /db_xref="EnsemblGenomes-Tr:CAB12796" /db_xref="GOA:O07587" /db_xref="InterPro:IPR004838" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG13024" /db_xref="UniProtKB/Swiss-Prot:O07587" /translation="MKLAGLSREVEENLNKGSWIRKLFDEGARLKKEFGEDQVFDFSL GNPIVEPPEAFKRALIEEAEKGSHGYIQNQGLLAAREKVAQFLGSRFEADFSAERIVM TVGAGGALNVALKSIVNPGEEVIILAPYFAEYKLYIENYGGKAVSCPLTSRFEIDIEA VRQSITPQTKGLILNTPHNPTGTVLSQKNIDDLGALLKEIEEKSGQTIYVLFDEPYSQ LIYDEELANPFQSYHRVILASSFSKDLGIAGERLGYIGLDSRMPDADLLINAFVYCNR TLGFVNAPVMMQRAVARMDDLRVDASAYKERRDLMVDILKEAGFEFEMPKGGFFVFPK SPIEDEVAFCVHAAQKYKLLIVPSSGFGMSGHFRLSFSVPIEQIKNSRDIFISLYKDF A*" /label="yhdR CDS" gene 983623..984804 /gene="yhdR" /locus_tag="BSU_09570" /old_locus_tag="BSU09570" /label="yhdR gene" downshifts 984789 /Source="Nicolas_upshifts" /id="D504" /incds=0 /nref=12 /ntot=180 /MaxReadThrough="2.81766" /MaxDrop="3.37889" /score="-5.8634451" /energy="-9.1" /TU="U759" /idTUdmin="U759" /TUdmin="-163" /isTUend="FALSE" /label="downshifts" S_feature 984834..984972 /Source="Nicolas_S_feature" /locus_tag="new_1035257_1035395" /HighExp="Etha, S1, BMM, S2, Cold, MG 45, MG 25, C90, T-5.40H, MG 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S332" misc_feature 984968..984987 /Source="Nicolas_upshift_promotors" /id="U760" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.771228771228771" /psig="0.999000999001" /xcortree=460 /SigmaFactorBS="aaggctttcttcatgataaaagtctaaaaattaaaaatcatt tttggaatgagtTGTGTTACAATAAAATATACaatttataatcaaactttgacttttg g" /listShort="S333, yhdT" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 984974..985130 /Source="Nicolas_S_feature" /locus_tag="new_1035397_1035553" /HighExp="M9-stat, B60, T4.0H, T3.0H, LoTm, S5, T5.0H, S4, T2.30H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigA" /TUlongPSig="0.996" /label="S333" upshifts 984974 /Source="Nicolas_upshifts" /id="U760" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.771228771228771" /psig="0.999000999001" /xcortree=460 /SigmaFactorBS="aaggctttcttcatgataaaagtctaaaaattaaaaatcatt tttggaatgagtTGTGTTACAATAAAATATACaatttataatcaaactttgacttttg g" /listShort="S333, yhdT" /GFF_Attribute="listLong" /label="upshifts" CDS 985131..986516 /gene="yhdT" /locus_tag="BSU_09590" /old_locus_tag="BSU09590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="NP_388840.1" /db_xref="EnsemblGenomes-Gn:BSU09590" /db_xref="EnsemblGenomes-Tr:CAB12798" /db_xref="GOA:O07589" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR002550" /db_xref="InterPro:IPR005170" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR036318" /db_xref="SubtiList:BG13026" /db_xref="UniProtKB/Swiss-Prot:O07589" /translation="MDDIDSLILIGVLIALTAFFVASEFAIVRVRRSRIDQLITEGNK RAILARRVITDLDEYLSASQLGITLTSIGLGVLGEPAFERLLHPLFEPLGLPDSVSHA VSFAVAYGLITFLHVVVGELAPKTVAIQKAEQLTLLIAGPLRLFYLLLFPFIWILNGS ARLLCGMFGLKPASEHDGSHSEEELRMLLSESLKNGEINPSEYKYVNKIFEFDNRIAK EIMIPRKEMAAVSTEMTMAEMLEVMLKEKYTRWPVTDGDKDSVLGLVNTKHLFSDLLF MTEEERMKMTIHPYVRPVIEVIETIPVHDLLIKMQRERIHMAILSDEYGGTSGLVTTE DILEEIVGEIRDEFDEDEQPLIQKLGDGHYVMDGKVRIDQVNSLLGASIQEDVDTIGG LILKENIDIEAGESIRIGSYTIKVLKMDGRLIKQIDIKEEAGNTTGITAHHKLPLPEP VMLNSATLSEK*" /label="yhdT CDS" gene 985131..986516 /gene="yhdT" /locus_tag="BSU_09590" /old_locus_tag="BSU09590" /label="yhdT gene" downshifts 986406 /Source="Nicolas_upshifts" /id="D505" /incds=1 /nref=120 /ntot=240 /MaxReadThrough="5.11037" /MaxDrop="3.79021" /score="19.6985636" /energy="-10.5" /TU="U760" /idTUdmin="U760" /TUdmin="-86" /isTUend="FALSE" /label="downshifts" downshifts 986492 /Source="Nicolas_upshifts" /id="D506" /incds=0 /nref=129 /ntot=245 /MaxReadThrough="1.68999" /MaxDrop="6.12682" /score="19.6985636" /energy="-10.5" /TU="NA" /idTUdmin="U760" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(986530..986886) /gene="crcBA" /locus_tag="BSU_09600" /old_locus_tag="BSU09600" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8844142, 12904550, 15849754, 16850406, 17196979, 22194412, 27824896; Product type t: transporter" /codon_start=1 /transl_table=11 /product="fluoride efflux channel component A" /protein_id="NP_388841.1" /db_xref="EnsemblGenomes-Gn:BSU09600" /db_xref="EnsemblGenomes-Tr:CAB12799" /db_xref="GOA:O07590" /db_xref="InterPro:IPR003691" /db_xref="SubtiList:BG13027" /db_xref="UniProtKB/Swiss-Prot:O07590" /translation="MTLAGIFIGGGLGAMLRFWLGNVITAKTKGLSLPIGILTVNILG ALGLGIFTGLHVANASVSLIIGTGFFGAFTTFSTFSVETIQLLMAKRVKESILYIVLT LCGSLFAFWCGWTITI*" /label="crcBA CDS" gene complement(986530..986886) /gene="crcBA" /locus_tag="BSU_09600" /old_locus_tag="BSU09600" /label="crcBA gene" CDS complement(986883..987278) /gene="crcBB" /locus_tag="BSU_09610" /old_locus_tag="BSU09610" /function="16.1: Circulate" /function="16.4: Excrete" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8844142, 12904550, 15849754, 16850406, 22194412, 27824896; Product type t : transporter" /codon_start=1 /transl_table=11 /product="subunit of fluoride efflux transporter" /protein_id="NP_388842.1" /db_xref="EnsemblGenomes-Gn:BSU09610" /db_xref="EnsemblGenomes-Tr:CAB12800" /db_xref="GOA:O07591" /db_xref="InterPro:IPR003691" /db_xref="SubtiList:BG13028" /db_xref="UniProtKB/Swiss-Prot:O07591" /translation="MKIYSAVFIGGALGACLRYGLNLWIHTGQFPAATWLENAAGSLL LGILTGFFMIGAKRPLLSAFLGTGFCGGFTTMSTFSKETVMLLQGQPSLALLYVAASL ISGIIFALIGVFVGRRIAGIQQRKGLQEK*" /label="crcBB CDS" gene complement(986883..987278) /gene="crcBB" /locus_tag="BSU_09610" /old_locus_tag="BSU09610" /label="crcBB gene" CDS complement(987265..987996) /gene="yhdW" /locus_tag="BSU_09620" /old_locus_tag="BSU09620" /EC_number="3.1.4.46" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8012593; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycerophosphodiester phosphodiesterase" /protein_id="NP_388843.1" /db_xref="EnsemblGenomes-Gn:BSU09620" /db_xref="EnsemblGenomes-Tr:CAB12801" /db_xref="GOA:O07592" /db_xref="InterPro:IPR004129" /db_xref="InterPro:IPR017946" /db_xref="InterPro:IPR030395" /db_xref="SubtiList:BG13029" /db_xref="UniProtKB/Swiss-Prot:O07592" /translation="MYIIAHRGASGYAPENTIAAFDLAVKMNADMIELDVQLTKDRQI VVIHDDRVDRTTNGSGFVKDFTLEELQKLDAGSWYGPAFQGERIPTLEAVLKRYHKKI GLLIELKGHPSQVGIEEEVGQLLGQFSFSINNIVQSFQFRSVQRFRELYPSIPTAVIT RPNFGMLSRNQMKAFRSFANYVNIKHTRLNRLMIGSINKNGLNIFAWTVNNQKTAAKL QAMGVDGIVTDYPDFIIKDGKHENI*" /label="yhdW CDS" gene complement(987265..987996) /gene="yhdW" /locus_tag="BSU_09620" /old_locus_tag="BSU09620" /label="yhdW gene" misc_feature complement(988021..988040) /Source="Nicolas_upshift_promotors" /id="U761" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.683316683316683" /psig="0.986013986013986" /xcortree=3010 /SigmaFactorBS="gcccggaccattccgatatggcagaaaaaattcaccagtttg tatcgcggtgcatatatggaTTTGATACAATAACAGAAATgcccatacgaggagctga c" /listShort="yhdW, yhdV, crcBA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(988042) /Source="Nicolas_upshifts" /id="U761" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.683316683316683" /psig="0.986013986013986" /xcortree=3010 /SigmaFactorBS="gcccggaccattccgatatggcagaaaaaattcaccagtttg tatcgcggtgcatatatggaTTTGATACAATAACAGAAATgcccatacgaggagctga c" /listShort="yhdW, yhdV, crcBA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 988089..988097 /Source="Nicolas_upshift_promotors" /id="U762" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.563436563436563" /psig="0.563436563436563" /xcortree=896 /SigmaFactorBS="atatgcaccgcgatacaaactggtgaattttttctgccatat cGGAATGGTCcgggctgaggaatGCGTATAACTAAAAAAagacactcagcgtatcaga a" /listShort="S334, yhdX" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 988106 /Source="Nicolas_upshifts" /id="U762" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.563436563436563" /psig="0.563436563436563" /xcortree=896 /SigmaFactorBS="atatgcaccgcgatacaaactggtgaattttttctgccatat cGGAATGGTCcgggctgaggaatGCGTATAACTAAAAAAagacactcagcgtatcaga a" /listShort="S334, yhdX" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 988111..988126 /Source="Nicolas_upshift_promotors" /id="U762" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.563436563436563" /psig="0.563436563436563" /xcortree=896 /SigmaFactorBS="atatgcaccgcgatacaaactggtgaattttttctgccatat cGGAATGGTCcgggctgaggaatGCGTATAACTAAAAAAagacactcagcgtatcaga a" /listShort="S334, yhdX" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 988120..988193 /Source="Nicolas_S_feature" /locus_tag="new_1038543_1038616" /HighExp="S5, S4, S6, S7, S8, S3, B60, Pyr, B36, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.563" /TUlongSig="NA" /TUlongPSig="NA" /label="S334" promotor_-35 988180..988181 /Source="Nicolas_upshift_promotors" /id="U763" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.937062937062937" /psig="0.998001998001998" /xcortree=461 /SigmaFactorBS="agcgtatcagaacacatttcgtcagaaaattaggtctttcga catGTtcacaacaaaatatgATCCTTTATAATAGCAAAAAaggaggcgagatcatggg a" /listShort="yhdX" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 988195 /Source="Nicolas_upshifts" /id="U763" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.937062937062937" /psig="0.998001998001998" /xcortree=461 /SigmaFactorBS="agcgtatcagaacacatttcgtcagaaaattaggtctttcga catGTtcacaacaaaatatgATCCTTTATAATAGCAAAAAaggaggcgagatcatggg a" /listShort="yhdX" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 988197..988216 /Source="Nicolas_upshift_promotors" /id="U763" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.937062937062937" /psig="0.998001998001998" /xcortree=461 /SigmaFactorBS="agcgtatcagaacacatttcgtcagaaaattaggtctttcga catGTtcacaacaaaatatgATCCTTTATAATAGCAAAAAaggaggcgagatcatggg a" /listShort="yhdX" /GFF_Attribute="listLong" /label="promotor_-10" CDS 988230..988337 /gene="yhdX" /locus_tag="BSU_09630" /old_locus_tag="BSU09630" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388844.1" /db_xref="EnsemblGenomes-Gn:BSU09630" /db_xref="EnsemblGenomes-Tr:CAB12802" /db_xref="InterPro:IPR035384" /db_xref="SubtiList:BG13030" /db_xref="UniProtKB/Swiss-Prot:O07593" /translation="MGKGRIRVEERIKAETDAEMQKATLLDQTQTKKGK*" /label="yhdX CDS" gene 988230..988337 /gene="yhdX" /locus_tag="BSU_09630" /old_locus_tag="BSU09630" /label="yhdX gene" S_feature 988338..988391 /Source="Nicolas_S_feature" /locus_tag="new_1038761_1038814" /HighExp="Sw, BC, LPhT, HiOs, S4, HiTm, S5, B36, S7, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S335" downshifts 988362 /Source="Nicolas_upshifts" /id="D507" /incds=0 /nref=177 /ntot=225 /MaxReadThrough="0.97838" /MaxDrop="7.47175" /score="21.9742676" /energy="-14.5" /TU="NA" /idTUdmin="U762" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature 988442..988461 /Source="Nicolas_upshift_promotors" /id="U764" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.381618381618382" /psig="0.931068931068931" /xcortree=1800 /SigmaFactorBS="tttcgccggggttttgtgctgcataagacatttaaatgaaca tccttacgaataTTTTAGTATAATAAACAATTgattgggatagaggggagacagtcat g" /listShort="yhdY, yhdZ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 988448 /Source="Nicolas_upshifts" /id="U764" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.381618381618382" /psig="0.931068931068931" /xcortree=1800 /SigmaFactorBS="tttcgccggggttttgtgctgcataagacatttaaatgaaca tccttacgaataTTTTAGTATAATAAACAATTgattgggatagaggggagacagtcat g" /listShort="yhdY, yhdZ" /GFF_Attribute="listLong" /label="upshifts" CDS 988486..989601 /gene="mscY" /locus_tag="BSU_09640" /old_locus_tag="BSU09640" /function="16.8: Protect" /function="16.12: Sense" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12077558, 15849754, 16850406, 17665170, 18310427, 19252899" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12077558, 15849754, 16850406, 17665170, 18310427, 19252899; Product type t : transporter" /codon_start=1 /transl_table=11 /product="small conductance mechano-sensitive channel" /protein_id="NP_388845.1" /db_xref="EnsemblGenomes-Gn:BSU09640" /db_xref="EnsemblGenomes-Tr:CAB12803" /db_xref="GOA:O07594" /db_xref="InterPro:IPR006685" /db_xref="InterPro:IPR006686" /db_xref="InterPro:IPR010920" /db_xref="InterPro:IPR011014" /db_xref="InterPro:IPR011066" /db_xref="SubtiList:BG13031" /db_xref="UniProtKB/Swiss-Prot:O07594" /translation="MPDYLQQYFTLDNIIQIGISLAILLVFLILRKLFTRYFFNLLFN LTNRPKTEIFKQVVLAFDKPARWFFVALGLFLAIRYSPFLDEQMPVISKIYRSLIVAL LCWGLCNLTATSSFIFHKVNQRFELDMDDILAPFLSKLLRFVIIALSVSVIAQEFNYD VNGFVAGLGLGGLAFALAAKDTISNFFGGIIIITEKPFTIGDWVETSTVTGSVEDITF RSTRFRTAQGALVTVPNSTLSMEAITNWTRMTKRQITFSIHVSYATPIENLERSIHSL RTMLLEHEGVDNEIIMVNFDTFADSYYNLFFNFYTKTTVWAENLNIREDINYKIIEIL GAEGVQFAYPGQMVVVKQKHESDQFQVNLNKEEKERA*" /label="mscY CDS" gene 988486..989601 /gene="mscY" /locus_tag="BSU_09640" /old_locus_tag="BSU09640" /label="mscY gene" downshifts 989581 /Source="Nicolas_upshifts" /id="D508" /incds=0 /nref=5 /ntot=141 /MaxReadThrough="3.45709" /MaxDrop="3.93891" /score="2.31392404" /energy="-12.3" /TU="U764" /idTUdmin="U764" /TUdmin="-783" /isTUend="FALSE" /label="downshifts" misc_feature 989638..989657 /Source="Nicolas_upshift_promotors" /id="U765" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.937062937062937" /psig=1 /xcortree=3140 /SigmaFactorBS="aaagaggaaaaggaacgggcttaaaagagagacttcgtctga cagaggcggagtctttttCATGGTAAAATAAGAGAAAAaggcggtgttgagttggaaa c" /listShort="yhdZ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 989638 /Source="Nicolas_upshifts" /id="U765" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.937062937062937" /psig=1 /xcortree=3140 /SigmaFactorBS="aaagaggaaaaggaacgggcttaaaagagagacttcgtctga cagaggcggagtctttttCATGGTAAAATAAGAGAAAAaggcggtgttgagttggaaa c" /listShort="yhdZ" /GFF_Attribute="listLong" /label="upshifts" CDS 989671..990414 /gene="srtN" /locus_tag="BSU_09650" /old_locus_tag="BSU09650" /EC_number="3.5.1.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16768447, 19136592, 26708127, 27987242" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16768447, 19136592, 26708127, 27987242; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sirtuin NAD-dependent deacetylase" /protein_id="NP_388846.1" /db_xref="EnsemblGenomes-Gn:BSU09650" /db_xref="EnsemblGenomes-Tr:CAB12804" /db_xref="GOA:O07595" /db_xref="InterPro:IPR003000" /db_xref="InterPro:IPR026590" /db_xref="InterPro:IPR028628" /db_xref="InterPro:IPR029035" /db_xref="SubtiList:BG13032" /db_xref="UniProtKB/Swiss-Prot:O07595" /translation="METFKSILHEAQRIVVLTGAGMSTESGIPDFRSAGGIWTEDASR MEAMSLDYFLSYPRLFWPKFKELFQMKMSGSFEPNEGHLLLAELEKQGKQVDIFTQNI DGLHKKAGSRHVYELHGSIQTAACPACGARYDLPHLLEREVPECTAAGNNGDICGTVL KTDVVLFGDAVMHFDTLYEKLDQADLLLVIGTSLEVAPARFVPEDASLIPGMKKVIIN LEPTYCDSLFDMVIHQKIGEFARSLGMKK*" /label="srtN CDS" gene 989671..990414 /gene="srtN" /locus_tag="BSU_09650" /old_locus_tag="BSU09650" /label="srtN gene" downshifts 990386 /Source="Nicolas_upshifts" /id="D509" /incds=0 /nref=3 /ntot=82 /MaxReadThrough="1.93149" /MaxDrop="2.85561" /score="9.76884826" /energy="-9.2" /TU="NA" /idTUdmin="U765" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(990438..991286) /gene="yheN" /locus_tag="BSU_09660" /old_locus_tag="BSU09660" /EC_number="3.5.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative polysaccharide deacetylase" /protein_id="NP_388847.1" /db_xref="EnsemblGenomes-Gn:BSU09660" /db_xref="EnsemblGenomes-Tr:CAB12805" /db_xref="GOA:O07596" /db_xref="InterPro:IPR002509" /db_xref="InterPro:IPR011330" /db_xref="SubtiList:BG13046" /db_xref="UniProtKB/Swiss-Prot:O07596" /translation="MRQTRGEASPSAVSLAFKFASLAVLCVLLLLMVILGYSNSSTKA KEVTVTTNGQLRDEKESLKLKNDSPDLLIKHLQTKQNMGDKTVYLTFDDGPSAVTTRL LDVLKSADVKATFFMLSPRMNEFKQAVKRAEKEGHALGLHGVTHNNRLFYQTPTSPLK EMQEARDTLQDITGYKTDLVRTPYGSKPSLTASQIRNLEKDGFVYWDWTIDSMDWKYR NSQYVTAVLQQLENMEHSSSSRPNVILMHDLPATVNALPVLINKLKEKGYSFGVLEDT MVPVHE*" /label="yheN CDS" gene complement(990438..991286) /gene="yheN" /locus_tag="BSU_09660" /old_locus_tag="BSU09660" /label="yheN gene" downshifts complement(990462) /Source="Nicolas_upshifts" /id="D510" /incds=0 /nref=126 /ntot=242 /MaxReadThrough="2.03966" /MaxDrop="4.72968" /score="-7.82934513" /energy="-9.2" /TU="NA" /idTUdmin="U767" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 991282..991287 /Source="Nicolas_upshift_promotors" /id="U766" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1125 /SigmaFactorBS="cgaaactgcagaaggagaagcctctcctctcgtttgtCGCAT AacaatctctccattgGCATAAAATCTCTACATAAtgctgtacagcaggcagcttatg a" /listShort="S337, S338, dat" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(991287..991386) /Source="Nicolas_S_feature" /locus_tag="new_1041710_1041809_c" /HighExp="Cold, T3.0H, T2.30H, T3.30H, T4.0H, T2.0H, HPh, C30, T1.30H, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S336" promotor_-10 991303..991321 /Source="Nicolas_upshift_promotors" /id="U766" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1125 /SigmaFactorBS="cgaaactgcagaaggagaagcctctcctctcgtttgtCGCAT AacaatctctccattgGCATAAAATCTCTACATAAtgctgtacagcaggcagcttatg a" /listShort="S337, S338, dat" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 991305 /Source="Nicolas_upshifts" /id="U766" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1125 /SigmaFactorBS="cgaaactgcagaaggagaagcctctcctctcgtttgtCGCAT AacaatctctccattgGCATAAAATCTCTACATAAtgctgtacagcaggcagcttatg a" /listShort="S337, S338, dat" /GFF_Attribute="listLong" /label="upshifts" S_feature 991310..991505 /Source="Nicolas_S_feature" /locus_tag="new_1041733_1041928" /HighExp="S5, S4, S6, S3, S7, S8, LoTm, B36, T5.0H, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S337" promotor_-10 complement(991375..991394) /Source="Nicolas_upshift_promotors" /id="U767" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.57042957042957" /psig=1 /xcortree=2149 /SigmaFactorBS="ttttttccttaaaatctgacatttcgacaaattttctATGTg ctttccagttttaTTCCTGTATACTTGACTGGTaatacataggttgtaaacataaggc a" /listShort="S336, yheN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(991389) /Source="Nicolas_upshifts" /id="U767" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.57042957042957" /psig=1 /xcortree=2149 /SigmaFactorBS="ttttttccttaaaatctgacatttcgacaaattttctATGTg ctttccagttttaTTCCTGTATACTTGACTGGTaatacataggttgtaaacataaggc a" /listShort="S336, yheN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(991409..991412) /Source="Nicolas_upshift_promotors" /id="U767" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.57042957042957" /psig=1 /xcortree=2149 /SigmaFactorBS="ttttttccttaaaatctgacatttcgacaaattttctATGTg ctttccagttttaTTCCTGTATACTTGACTGGTaatacataggttgtaaacataaggc a" /listShort="S336, yheN" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 991504..991523 /Source="Nicolas_upshift_promotors" /id="U768" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=2940 /SigmaFactorBS="aaataaactcctttccgctatagatctcttgatctttctgtt tttcagcttgtccaaTATGGTAGAATTAGTGATAAtgacagcttgaatgacatcaggg a" /listShort="S338, dat" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 991507..991570 /Source="Nicolas_S_feature" /locus_tag="new_1041930_1041993" /HighExp="BC, T2.30H, T3.0H, T3.30H, T4.0H, T5.0H, T2.0H, T1.30H, S4, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S338" upshifts 991507 /Source="Nicolas_upshifts" /id="U768" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=2940 /SigmaFactorBS="aaataaactcctttccgctatagatctcttgatctttctgtt tttcagcttgtccaaTATGGTAGAATTAGTGATAAtgacagcttgaatgacatcaggg a" /listShort="S338, dat" /GFF_Attribute="listLong" /label="upshifts" CDS 991571..992419 /gene="dat" /locus_tag="BSU_09670" /old_locus_tag="BSU09670" /EC_number="2.6.1.21" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9003455, 17005988; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-alanine aminotransferase" /protein_id="NP_388848.1" /db_xref="EnsemblGenomes-Gn:BSU09670" /db_xref="EnsemblGenomes-Tr:CAB12806" /db_xref="GOA:O07597" /db_xref="InterPro:IPR001544" /db_xref="InterPro:IPR005784" /db_xref="InterPro:IPR018300" /db_xref="InterPro:IPR036038" /db_xref="SubtiList:BG13045" /db_xref="UniProtKB/Swiss-Prot:O07597" /translation="MKVLVNGRLIGRSEASIDLEDRGYQFGDGIYEVIRVYKGVLFGL REHAERFFRSAAEIGISLPFSIEDLEWDLQKLVQENAVSEGAVYIQTTRGVAPRKHQY EAGLEPQTTAYTFTVKKPEQEQAYGVAAITDEDLRWLRCDIKSLNLLYNVMTKQRAYE AGAFEAILLRDGVVTEGTSSNVYAVINGTVRTHPANRLILNGITRMNILGLIEKNGIK LDETPVSEEELKQAEEIFISSTTAEIIPVVTLDGQSIGSGKPGPVTKQLQAAFQESIQ QAASIS*" /label="dat CDS" gene 991571..992419 /gene="dat" /locus_tag="BSU_09670" /old_locus_tag="BSU09670" /label="dat gene" downshifts 992410 /Source="Nicolas_upshifts" /id="D511" /incds=0 /nref=232 /ntot=261 /MaxReadThrough="2.27201" /MaxDrop="6.88888" /score="21.6239924" /energy="-11.5" /TU="U768" /idTUdmin="U766" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(992462..993823) /gene="nhaC" /locus_tag="BSU_09680" /old_locus_tag="BSU09680" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10735849, 11274110, 15849754, 16850406, 17937670" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10735849, 11274110, 15849754, 16850406, 17937670; Product type t : transporter" /codon_start=1 /transl_table=11 /product="Na+/H+ antiporter" /protein_id="NP_388849.1" /db_xref="EnsemblGenomes-Gn:BSU09680" /db_xref="EnsemblGenomes-Tr:CAB12807" /db_xref="GOA:O07553" /db_xref="InterPro:IPR004770" /db_xref="InterPro:IPR018461" /db_xref="SubtiList:BG13044" /db_xref="UniProtKB/Swiss-Prot:O07553" /translation="MDSQKKLTFPLAVGLFIFMLCIIISCLFLLHVEPHIPLFLSVVM LSAAALWFGFPWKSIEKGIVDGIKNGVQPIIVLALIGILIGAWMYSGAIPTMTVYALS FIEPSHLLLTALFSCMIISTLVGSSLTTVSTIGVALIGVASAAGVPLEWTAGAVICGA CFGDKMSPMSDTTNFAAGIGEIPIFEHIRHMMGTTIPALLITVVLFYFLGSSVSADAA STDNIQQVITGIKDAANVTPWALLSPLLVVLLAMKRVSVIPVLTAGIISSGILTAIFV PYSSLQAFMTALQNGTTFETDNEAAAKIINRGGLQSMMGSVSLIMIAFALGGLMEKIG LISALLEGVMKGIRSKGRLVAATVCSSIGVNLATGEQYLSILIPGQSFKSLYDKRNIQ RKFLTRSLEDGGTLINPLIPWGVSGAFMASALGVPVIDYIPFTFFLYISPMISILIGF VKK*" /label="nhaC CDS" gene complement(992462..993823) /gene="nhaC" /locus_tag="BSU_09680" /old_locus_tag="BSU09680" /label="nhaC gene" downshifts complement(992486) /Source="Nicolas_upshifts" /id="D512" /incds=0 /nref=7 /ntot=77 /MaxReadThrough="0.50034" /MaxDrop="3.60175" /score="1.04025421" /energy="-11.5" /TU="NA" /idTUdmin="U769" /TUdmin=22 /isTUend="TRUE" /label="downshifts" S_feature complement(993824..993894) /Source="Nicolas_S_feature" /locus_tag="new_1044247_1044317_c" /HighExp="B60, G135, Etha, LBGexp, G150, Diami, Paraq, G180, H2O2, Gly" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="0.96, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S339" misc_feature complement(993867..993886) /Source="Nicolas_upshift_promotors" /id="U769" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.926073926073926" /psig="0.96003996003996" /xcortree=2470 /SigmaFactorBS="agtgagcacgccctgtgctcacttcttttatattcataattg tgaaaaaacatagattttcgttttttTCTGTTATAATGCTTTCGTGcccaaaagcaca a" /listShort="S339, nhaC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(993894) /Source="Nicolas_upshifts" /id="U769" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.926073926073926" /psig="0.96003996003996" /xcortree=2470 /SigmaFactorBS="agtgagcacgccctgtgctcacttcttttatattcataattg tgaaaaaacatagattttcgttttttTCTGTTATAATGCTTTCGTGcccaaaagcaca a" /listShort="S339, nhaC" /GFF_Attribute="listLong" /label="upshifts" CDS complement(993950..994450) /gene="nhaX" /locus_tag="BSU_09690" /old_locus_tag="BSU09690" /function="16.12: Sense" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11988534, 16159758, 27464829; Product type f: factor" /codon_start=1 /transl_table=11 /product="stress response protein, UspA family" /protein_id="NP_388850.2" /db_xref="EnsemblGenomes-Gn:BSU09690" /db_xref="EnsemblGenomes-Tr:CAB12808" /db_xref="GOA:O07552" /db_xref="InterPro:IPR006015" /db_xref="InterPro:IPR006016" /db_xref="InterPro:IPR014729" /db_xref="SubtiList:BG13043" /db_xref="UniProtKB/Swiss-Prot:O07552" /translation="MFHADRIIVAFDGSENSKKALLTAIDLAKTVNAAITVAHSHDMK DNQTVIDPPRPAAEASYISGGMTSVPDPLISDVTSPEPMIYEDRTEEVIAEARMMLNE QQADGDIDILEGDPAESIIEHANRISADMIVTGSRDQNRLKKLIFGSVSEKLSAKSDI PVLIVK*" /label="nhaX CDS" gene complement(993950..994450) /gene="nhaX" /locus_tag="BSU_09690" /old_locus_tag="BSU09690" /label="nhaX gene" downshifts complement(993982) /Source="Nicolas_upshifts" /id="D513" /incds=0 /nref=10 /ntot=63 /MaxReadThrough="4.74071" /MaxDrop="5.69273" /score="4.44189378" /energy="-12.2" /TU="U770" /idTUdmin="U770" /TUdmin="-1320" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(994472..994490) /Source="Nicolas_upshift_promotors" /id="U770" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=208 /SigmaFactorBS="aaacaaaaccttttattgtcaatcattacttgaataggaaaA GGTTAAttgtgctcaaattcGGGTAGTAGTGTTGTAAGAcgctttgaaagggtgagaa g" /listShort="nhaX, S339, nhaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(994492) /Source="Nicolas_upshifts" /id="U770" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=208 /SigmaFactorBS="aaacaaaaccttttattgtcaatcattacttgaataggaaaA GGTTAAttgtgctcaaattcGGGTAGTAGTGTTGTAAGAcgctttgaaagggtgagaa g" /listShort="nhaX, S339, nhaC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(994505..994511) /Source="Nicolas_upshift_promotors" /id="U770" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=208 /SigmaFactorBS="aaacaaaaccttttattgtcaatcattacttgaataggaaaA GGTTAAttgtgctcaaattcGGGTAGTAGTGTTGTAAGAcgctttgaaagggtgagaa g" /listShort="nhaX, S339, nhaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 994529..994536 /Source="Nicolas_upshift_promotors" /id="U771" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.918081918081918" /psig=1 /xcortree=416 /SigmaFactorBS="ctacccgaatttgagcacaattaaccttttcctattcaagta atGATTGACAataaaaggttttgtTTATATGATGATAAAAAGATgaaatcagaatgga a" /listShort="S340, yheJ, S341, yheI, yheH" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 994544..994613 /Source="Nicolas_S_feature" /locus_tag="new_1044967_1045036" /HighExp="C90, M9-stat, BC, T1.30H, T3.30H, Sw, T5.0H, GM 15, T3.0H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S340" upshifts 994545 /Source="Nicolas_upshifts" /id="U771" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.918081918081918" /psig=1 /xcortree=416 /SigmaFactorBS="ctacccgaatttgagcacaattaaccttttcctattcaagta atGATTGACAataaaaggttttgtTTATATGATGATAAAAAGATgaaatcagaatgga a" /listShort="S340, yheJ, S341, yheI, yheH" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 994551..994570 /Source="Nicolas_upshift_promotors" /id="U771" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.918081918081918" /psig=1 /xcortree=416 /SigmaFactorBS="ctacccgaatttgagcacaattaaccttttcctattcaagta atGATTGACAataaaaggttttgtTTATATGATGATAAAAAGATgaaatcagaatgga a" /listShort="S340, yheJ, S341, yheI, yheH" /GFF_Attribute="listLong" /label="promotor_-10" CDS 994614..994775 /gene="bmrB" /locus_tag="BSU_09700" /old_locus_tag="BSU09700" /experiment="publication(s) with functional evidences, PMID:25217586" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25217586; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator leader peptide" /protein_id="NP_388851.1" /db_xref="EnsemblGenomes-Gn:BSU09700" /db_xref="EnsemblGenomes-Tr:CAB12809" /db_xref="SubtiList:BG13042" /db_xref="UniProtKB/Swiss-Prot:O07551" /translation="MFIKQFHIGAANLLFCFRERFFRSDRALKSAVRNISVKKGMELT LHAFFIYKI*" /label="bmrB CDS" gene 994614..994775 /gene="bmrB" /locus_tag="BSU_09700" /old_locus_tag="BSU09700" /label="bmrB gene" downshifts 994705 /Source="Nicolas_upshifts" /id="D514" /incds=1 /nref=29 /ntot=180 /MaxReadThrough="5.31538" /MaxDrop="4.59672" /score="25.6910195" /energy="-14.4" /TU="U771" /idTUdmin="U768" /TUdmin=2273 /isTUend="FALSE" /label="downshifts" S_feature 994776..994894 /Source="Nicolas_S_feature" /locus_tag="new_1045199_1045317" /HighExp="LPhT, S7, S6, T-1.10H, Sw, LBGstat, S5, T-0.40H, S8, T-1.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S341" CDS 994895..996652 /gene="bmrC" /locus_tag="BSU_09710" /old_locus_tag="BSU09710" /function="16.1: Circulate" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15855514, 16487324, 19167342, 21602923, 25217586" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15855514, 16487324, 19167342, 21602923, 25217586; Product type t : transporter" /codon_start=1 /transl_table=11 /product="efflux ABC transporter (ATP-binding protein)" /protein_id="NP_388852.1" /db_xref="EnsemblGenomes-Gn:BSU09710" /db_xref="EnsemblGenomes-Tr:CAB12810" /db_xref="GOA:O07550" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG13041" /db_xref="UniProtKB/Swiss-Prot:O07550" /translation="MFSVLKKLGWFFKAYWLRYTIAIVLLLAVNVIEMFPPKLLGNAI DDMKAGAFTAEGLLFYIGIFFVLTAAVYIMSYFWMHQLFGGANLMEKILRTKLMGHLL TMSPPFYEKNRTGDLMARGTNDLQAVSLTTGFGILTLVDSTMFMMTIFLTMGFLISWK LTFAAIIPLPVMAIAISLYGSKIHERFTEAQNAFGALNDRVLESVSGVRVIRAYVQET NDVRRFNEMTADVYQKNMKVAFIDSLFEPTVKLLVGASYLIGLGYGAFLVFRNELTLG ELVSFNVYLGMMIWPMFAIGELINVMQRGNASLDRVNETLSYETDVTDPKQPADLKEP GDIVFSHVSFTYPSSTSDNLQDISFTVRKGQTVGIAGKTGSGKTTIIKQLLRQYPPGE GSITFSGVPIQQIPLDRLRGWIGYVPQDHLLFSRTVKENILYGKQDATDKEVQQAIAE AHFEKDLHMLPSGLETMVGEKGVALSGGQKQRISIARALMANPEILILDDSLSAVDAK TEAAIIKNIRENRKGKTTFILTHRLSAVEHADLILVMDGGVIAERGTHQELLANNGWY REQYERQQLFTAEEGGAGA*" /label="bmrC CDS" gene 994895..996652 /gene="bmrC" /locus_tag="BSU_09710" /old_locus_tag="BSU09710" /label="bmrC gene" CDS 996649..998670 /gene="bmrD" /locus_tag="BSU_09720" /old_locus_tag="BSU09720" /function="16.1: Circulate" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15855514, 16487324, 19167342, 21602923, 25217586" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15855514, 16487324, 19167342, 21602923, 25217586; Product type t : transporter" /codon_start=1 /transl_table=11 /product="efflux ABC transporter (ATP-binding subunit)" /protein_id="NP_388853.1" /db_xref="EnsemblGenomes-Gn:BSU09720" /db_xref="EnsemblGenomes-Tr:CAB12811" /db_xref="GOA:O07549" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG13040" /db_xref="UniProtKB/Swiss-Prot:O07549" /translation="MKIGKTLWRYALLYRKLLITAVLLLTVAVGAELTGPFIGKKMID DHILGIEKTWYEAAEKDKNAVQFHGVSYVREDRLQEPVSKAKEAHIYQVGMAFYFVDQ AVSFDGNRTVSDGKLTITNGDKSRAYAAEKLTKQELFQFYQPEIKGMVLLICLYGGLL VFSVFFQYGQHYLLQMSANRIIQKMRQDVFSHIQKMPIRYFDNLPAGKVVARITNDTE AIRDLYVTVLSTFVTSGIYMFGIFTALFLLDVKLAFVCLAIVPIIWLWSVIYRRYASY YNQKIRSINSDINAKMNESIQGMTIIQAFRHQKETMREFEELNESHFYFQNRMLNLNS LMSHNLVNVIRNLAFVCLIWHFGGASLNAAGIVSIGVLYAFVDYLNRLFQPITGIVNQ FSKLELARVSAGRVFELLEEKNTEEAGEPAKERALGRVEFRDVSFAYQEGEEVLKHIS FTAQKGETVALVGHTGSGKSSILNLLFRFYDAQKGDVLIDGKSIYNMSRQELRSHMGI VLQDPYLFSGTIGSNVSLDDERMTEEEIKNALRQVGAEPLLKKLPKGINEPVIEKGST LSSGERQLISFARALAFDPAILILDEATAHIDTETEAVIQKALDVVKQGRTTFVIAHR LSTIRNADQILVLDKGEIVERGNHEELMALEGQYYQMYELQKGQKHSIA*" /label="bmrD CDS" gene 996649..998670 /gene="bmrD" /locus_tag="BSU_09720" /old_locus_tag="BSU09720" /label="bmrD gene" downshifts 998658 /Source="Nicolas_upshifts" /id="D515" /incds=0 /nref=69 /ntot=230 /MaxReadThrough="0.741399999999999" /MaxDrop="5.11492" /score="9.67206405" /energy="-10.9" /TU="NA" /idTUdmin="U771" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(998719..999339) /gene="yheG" /locus_tag="BSU_09730" /old_locus_tag="BSU09730" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NADH-flavin oxidoreductase" /protein_id="NP_388854.1" /db_xref="EnsemblGenomes-Gn:BSU09730" /db_xref="EnsemblGenomes-Tr:CAB12812" /db_xref="InterPro:IPR016040" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13039" /db_xref="UniProtKB/Swiss-Prot:O07548" /translation="MKIALLGASGRVGQAFLTQAAADERFDIFALIRSQHADLPLSKD RTVMGNARRLEDVKKIMENAEIVISCLGTDGDDTLSTAMAHILSVMEEQHIKRLITIG TAGILDSRYEPGKYRFETNESKRKQTRAAKEHAKVYEMLKESSLDWTIICPTYLPDGT ATGVYRTERNVLPEGGTSISVGDTADFLYRELVTGEYVGNRVGLAY*" /label="yheG CDS" gene complement(998719..999339) /gene="yheG" /locus_tag="BSU_09730" /old_locus_tag="BSU09730" /label="yheG gene" downshifts complement(998734) /Source="Nicolas_upshifts" /id="D516" /incds=0 /nref=19 /ntot=169 /MaxReadThrough="1.82652" /MaxDrop="3.00293" /score="-0.293143554" /energy="-10.9" /TU="NA" /idTUdmin="U772" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_no_box 999324..999424 /Source="Nicolas_upshift_promotors" /id="U773" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.45954045954046" /psig="0.043956043956044" /xcortree=770 /SigmaFactorBS="ataaagcgattttcattaaaaaacctcctcgcctttcattat aaaaggatgttctcagtttgaacagcgcgggaaagaatacctgtacaaataaacagaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-10 complement(999353..999372) /Source="Nicolas_upshift_promotors" /id="U772" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.844155844155844" /psig="0.955044955044955" /xcortree=2213 /SigmaFactorBS="catcgttctgtttatttgtacaggtattctttcccgcgCTGT tcaaactgagaacaTCCTTTTATAATGAAAGGCGaggaggttttttaatgaaaatcgc t" /listShort="yheG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(999368) /Source="Nicolas_upshifts" /id="U772" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.844155844155844" /psig="0.955044955044955" /xcortree=2213 /SigmaFactorBS="catcgttctgtttatttgtacaggtattctttcccgcgCTGT tcaaactgagaacaTCCTTTTATAATGAAAGGCGaggaggttttttaatgaaaatcgc t" /listShort="yheG" /GFF_Attribute="listLong" /label="upshifts" CDS complement(999378..999503) /gene="yheF" /locus_tag="BSU_09740" /old_locus_tag="BSU09740" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388855.1" /db_xref="EnsemblGenomes-Gn:BSU09740" /db_xref="EnsemblGenomes-Tr:CAB12813" /db_xref="SubtiList:BG13038" /db_xref="UniProtKB/Swiss-Prot:O07547" /translation="MSFITIVNWELVQFVSVSMIHEYVSHRSVYLYRYSFPRCSN*" /label="yheF CDS" gene complement(999378..999503) /gene="yheF" /locus_tag="BSU_09740" /old_locus_tag="BSU09740" /label="yheF gene" upshifts 999384 /Source="Nicolas_upshifts" /id="U773" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.45954045954046" /psig="0.043956043956044" /xcortree=770 /SigmaFactorBS="ataaagcgattttcattaaaaaacctcctcgcctttcattat aaaaggatgttctcagtttgaacagcgcgggaaagaatacctgtacaaataaacagaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(999387..999390) /Source="Nicolas_upshift_promotors" /id="U772" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.844155844155844" /psig="0.955044955044955" /xcortree=2213 /SigmaFactorBS="catcgttctgtttatttgtacaggtattctttcccgcgCTGT tcaaactgagaacaTCCTTTTATAATGAAAGGCGaggaggttttttaatgaaaatcgc t" /listShort="yheG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(999517..999536) /Source="Nicolas_upshift_promotors" /id="U774" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1332 /SigmaFactorBS="agggcgcggtttccgcgctctctttatTTTGTCACCCttttt tcctgctcCACATATCCTAGAAAAAAAGggagggaatcggggtgtcattcatcaccat t" /listShort="yheF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(999526) /Source="Nicolas_upshifts" /id="U774" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1332 /SigmaFactorBS="agggcgcggtttccgcgctctctttatTTTGTCACCCttttt tcctgctcCACATATCCTAGAAAAAAAGggagggaatcggggtgtcattcatcaccat t" /listShort="yheF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(999550..999559) /Source="Nicolas_upshift_promotors" /id="U774" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1332 /SigmaFactorBS="agggcgcggtttccgcgctctctttatTTTGTCACCCttttt tcctgctcCACATATCCTAGAAAAAAAGggagggaatcggggtgtcattcatcaccat t" /listShort="yheF" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 999582 /Source="Nicolas_upshifts" /id="D517" /incds=0 /nref=6 /ntot=22 /MaxReadThrough="0.352760000000001" /MaxDrop="4.67633" /score="9.67206405" /energy="-10.9" /TU="NA" /idTUdmin="U773" /TUdmin=88 /isTUend="FALSE" /label="downshifts" CDS complement(999608..999811) /gene="sspB" /locus_tag="BSU_09750" /old_locus_tag="BSU09750" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:3009398, 9572981, 16707666, 19659696, 26790838" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3009398, 9572981, 16707666, 19659696, 26790838; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein (beta-type SASP)" /protein_id="NP_388856.1" /db_xref="EnsemblGenomes-Gn:BSU09750" /db_xref="EnsemblGenomes-Tr:CAB12814" /db_xref="GOA:P04832" /db_xref="InterPro:IPR001448" /db_xref="InterPro:IPR018126" /db_xref="SubtiList:BG10787" /db_xref="UniProtKB/Swiss-Prot:P04832" /translation="MANQNSSNDLLVPGAAQAIDQMKLEIASEFGVNLGADTTSRANG SVGGEITKRLVSFAQQQMGGRVQ*" /label="sspB CDS" gene complement(999608..999811) /gene="sspB" /locus_tag="BSU_09750" /old_locus_tag="BSU09750" /label="sspB gene" downshifts complement(999613) /Source="Nicolas_upshifts" /id="D518" /incds=0 /nref=72 /ntot=93 /MaxReadThrough="1.27819" /MaxDrop="8.55895" /score="22.2113888" /energy="-16" /TU="NA" /idTUdmin="U776" /TUdmin=1 /isTUend="TRUE" /label="downshifts" S_feature complement(999812..999922) /Source="Nicolas_S_feature" /locus_tag="new_1050235_1050345_c" /HighExp="S8, S5, S7, S6, S4, G/S, Pyr, ferm, BT, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S342" promotor_no_box 999852..999952 /Source="Nicolas_upshift_promotors" /id="U775" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.665334665334665" /psig="0.090909090909091" /xcortree=696 /SigmaFactorBS="ggagttgcaccaatctgtgaacccttctcgggtgtcactgcc gcctcggcgtaacccaatgctttgccggcttgttactacgtattatgttaaaatggcc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 999912 /Source="Nicolas_upshifts" /id="U775" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.665334665334665" /psig="0.090909090909091" /xcortree=696 /SigmaFactorBS="ggagttgcaccaatctgtgaacccttctcgggtgtcactgcc gcctcggcgtaacccaatgctttgccggcttgttactacgtattatgttaaaatggcc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(999928) /Source="Nicolas_upshifts" /id="U776" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=836 /SigmaFactorBS="ctcaagatttaccacacaattctcCGCATGAttttccggcca tttTAACATAATACGtagtaacaagccggcaaagcattgggttacgccgaggcggcag t" /listShort="S342, sspB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(999932..999943) /Source="Nicolas_upshift_promotors" /id="U776" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=836 /SigmaFactorBS="ctcaagatttaccacacaattctcCGCATGAttttccggcca tttTAACATAATACGtagtaacaagccggcaaagcattgggttacgccgaggcggcag t" /listShort="S342, sspB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(999958..999964) /Source="Nicolas_upshift_promotors" /id="U776" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=836 /SigmaFactorBS="ctcaagatttaccacacaattctcCGCATGAttttccggcca tttTAACATAATACGtagtaacaagccggcaaagcattgggttacgccgaggcggcag t" /listShort="S342, sspB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1000020..1000238) /gene="yheE" /locus_tag="BSU_09760" /old_locus_tag="BSU09760" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein (sporulation / germination island)" /protein_id="NP_388857.1" /db_xref="EnsemblGenomes-Gn:BSU09760" /db_xref="EnsemblGenomes-Tr:CAB12815" /db_xref="InterPro:IPR017263" /db_xref="SubtiList:BG13037" /db_xref="UniProtKB/Swiss-Prot:O07546" /translation="MAVMISHFSWKPLFPKEKLPGWKISFYYKGTHYEGIYHKSGEIE WGDLFPARADEPALTNEIHELMLFHIYD*" /label="yheE CDS" gene complement(1000020..1000238) /gene="yheE" /locus_tag="BSU_09760" /old_locus_tag="BSU09760" /label="yheE gene" downshifts complement(1000054) /Source="Nicolas_upshifts" /id="D519" /incds=0 /nref=5 /ntot=83 /MaxReadThrough="0.43384" /MaxDrop="3.42951" /score="37.4339943" /energy="-11.8" /TU="NA" /idTUdmin="U777" /TUdmin=110 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1000279..1000298) /Source="Nicolas_upshift_promotors" /id="U777" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.609390609390609" /psig="0.996003996003996" /xcortree=419 /SigmaFactorBS="ctttatccaaagctgggacaaactgcatatttaggccTCTTC AATgatgttctgaaacAATGATACAATGAACATAAGccgtttttatttaggtcaattg a" /listShort="yheE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1000296) /Source="Nicolas_upshifts" /id="U777" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.609390609390609" /psig="0.996003996003996" /xcortree=419 /SigmaFactorBS="ctttatccaaagctgggacaaactgcatatttaggccTCTTC AATgatgttctgaaacAATGATACAATGAACATAAGccgtttttatttaggtcaattg a" /listShort="yheE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1000312..1000319) /Source="Nicolas_upshift_promotors" /id="U777" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.609390609390609" /psig="0.996003996003996" /xcortree=419 /SigmaFactorBS="ctttatccaaagctgggacaaactgcatatttaggccTCTTC AATgatgttctgaaacAATGATACAATGAACATAAGccgtttttatttaggtcaattg a" /listShort="yheE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1000388..1001749) /gene="spaD" /locus_tag="BSU_09770" /old_locus_tag="BSU09770" /function="16.5: Explore" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15231775, 25035995" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15231775, 25035995; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat associated protein" /protein_id="NP_388858.2" /db_xref="EnsemblGenomes-Gn:BSU09770" /db_xref="EnsemblGenomes-Tr:CAB12816" /db_xref="GOA:O07545" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR026838" /db_xref="SubtiList:BG13036" /db_xref="UniProtKB/Swiss-Prot:O07545" /translation="MNPKRFLIGIDKTSENTLFLPSSLKQDGLLHAAFGTKVVRCHVA YRRHLEQTVLLSENLFHELLLPHRSRADILIHDHTVHIGPLVGIFTAGFTVSLERPFK DRSLFFSKLVTLHEQAGGYCFVFGAHQINWEEGTIEGLLYRENGWEKKIVPLPNVVYD RLPNRKIEDSLLLQHTKKRLIDEYQIPWFNKTFFNKWNVHQLLEKDPRTAPFLPRSEL TPSVELIDELCGAYKKVYIKPANGALGTGIYQLTRTDGGLTVKHTNDAKTFTSIDYSD AASFLAEFQKHHNPSDFLIQQGVDLIEFQGKPADFRVHTNKNRKGKWTVTAIAVKISG KNSITTHLSNGGTVKTLAEVYDDPAERVEVIKKLSAAALTASHVLHDHIEGFIGEIGF DFGIDQNGKVWMFEANSRPGRSIFSHPNLHHVDSLTKRRSFEYASYLSEKAITSPEAL WPS*" /label="spaD CDS" gene complement(1000388..1001749) /gene="spaD" /locus_tag="BSU_09770" /old_locus_tag="BSU09770" /label="spaD gene" downshifts complement(1000406) /Source="Nicolas_upshifts" /id="D520" /incds=0 /nref=3 /ntot=26 /MaxReadThrough="2.33323" /MaxDrop="3.7968" /score="37.4339943" /energy="-11.8" /TU="NA" /idTUdmin="U779" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1000450) /Source="Nicolas_upshifts" /id="D521" /incds=1 /nref=2 /ntot=45 /MaxReadThrough="5.29177" /MaxDrop="3.36501" /score="37.4339943" /energy="-11.8" /TU="U779" /idTUdmin="U779" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" CDS complement(1001739..1002830) /gene="spaC" /locus_tag="BSU_09780" /old_locus_tag="BSU09780" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15231775, 25035995; Product type f: factor" /codon_start=1 /transl_table=11 /product="spore coat associated protein, subunit C" /protein_id="NP_388859.1" /db_xref="EnsemblGenomes-Gn:BSU09780" /db_xref="EnsemblGenomes-Tr:CAB12817" /db_xref="GOA:O07544" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR026838" /db_xref="SubtiList:BG13035" /db_xref="UniProtKB/Swiss-Prot:O07544" /translation="MITLGFMSLSRQHEADYSAELAKRAPEFGIRFIRFTPFDISPDT LRVKASVYHSASSTWNETEMAIPDYIYDRCFYGKDSHSQKAKPIVEWLKKYPKTEFIG RGLPDKWTVLHDLQQHSVINPYIPETIKVSRYEQIHSFLSKEKACILKPAFGAGGRGV ILLKLGKKNITATYHIGKDKQTKTFSNQTSFKTWCKKVLQHQYLLQPYLNIQDKEQYP CDIRLFMEKNEAGEWNTVGKAVRRGYKHGLLANLSGGSDALTFDSWFEDIPKKQQVVL LDDVFSITQSVPYYLDERYGPLFELGLDICLAKDGRIWILDINSKPGRKSILRVSPEQ KEQLYTCPLKRCQYLFSEQSQKGVLPRES*" /label="spaC CDS" gene complement(1001739..1002830) /gene="spaC" /locus_tag="BSU_09780" /old_locus_tag="BSU09780" /label="spaC gene" promotor_-10 complement(1002154..1002168) /Source="Nicolas_upshift_promotors" /id="U778" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.63936063936064" /psig="0.63936063936064" /xcortree=613 /SigmaFactorBS="aatatttgcttcagccttacttaaacattcaagataAGGAAC AATacccttgtgatatTCGTCTGTTTATGGAaaaaaacgaagcaggtgaatggaatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1002166) /Source="Nicolas_upshifts" /id="U778" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.63936063936064" /psig="0.63936063936064" /xcortree=613 /SigmaFactorBS="aatatttgcttcagccttacttaaacattcaagataAGGAAC AATacccttgtgatatTCGTCTGTTTATGGAaaaaaacgaagcaggtgaatggaatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1002182..1002190) /Source="Nicolas_upshift_promotors" /id="U778" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.63936063936064" /psig="0.63936063936064" /xcortree=613 /SigmaFactorBS="aatatttgcttcagccttacttaaacattcaagataAGGAAC AATacccttgtgatatTCGTCTGTTTATGGAaaaaaacgaagcaggtgaatggaatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(1002831..1002936) /Source="Nicolas_S_feature" /locus_tag="new_1053254_1053359_c" /HighExp="S4, B36, S5, S6, S7, S8, B60, S3, T5.0H, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S343" promotor_-10 complement(1002920..1002938) /Source="Nicolas_upshift_promotors" /id="U779" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1099 /SigmaFactorBS="ggagacaaattcctgttcttagaaaatcagcttgttcttttG GAATAgggcaaggtggagaaTCGTATTCTGTAAAGTAGAataccgtcagctgcgttcg t" /listShort="S343, yheC, yheD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1002940) /Source="Nicolas_upshifts" /id="U779" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1099 /SigmaFactorBS="ggagacaaattcctgttcttagaaaatcagcttgttcttttG GAATAgggcaaggtggagaaTCGTATTCTGTAAAGTAGAataccgtcagctgcgttcg t" /listShort="S343, yheC, yheD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1002954..1002959) /Source="Nicolas_upshift_promotors" /id="U779" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1099 /SigmaFactorBS="ggagacaaattcctgttcttagaaaatcagcttgttcttttG GAATAgggcaaggtggagaaTCGTATTCTGTAAAGTAGAataccgtcagctgcgttcg t" /listShort="S343, yheC, yheD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1003002..1003009 /Source="Nicolas_upshift_promotors" /id="U780" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2000 /SigmaFactorBS="ttttctaagaacaggaatttgtctcctCGTTTGCTaagtgat tgcatgaGCCTCTATAATACGTATAGGtacataatctatatgaaaaaagctgaagcac a" /listShort="yheB, S344, yheA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1003024..1003043 /Source="Nicolas_upshift_promotors" /id="U780" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2000 /SigmaFactorBS="ttttctaagaacaggaatttgtctcctCGTTTGCTaagtgat tgcatgaGCCTCTATAATACGTATAGGtacataatctatatgaaaaaagctgaagcac a" /listShort="yheB, S344, yheA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1003035 /Source="Nicolas_upshifts" /id="U780" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2000 /SigmaFactorBS="ttttctaagaacaggaatttgtctcctCGTTTGCTaagtgat tgcatgaGCCTCTATAATACGTATAGGtacataatctatatgaaaaaagctgaagcac a" /listShort="yheB, S344, yheA" /GFF_Attribute="listLong" /label="upshifts" CDS 1003097..1004230 /gene="yheB" /locus_tag="BSU_09790" /old_locus_tag="BSU09790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16684363" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388860.1" /db_xref="EnsemblGenomes-Gn:BSU09790" /db_xref="EnsemblGenomes-Tr:CAB12818" /db_xref="GOA:O07543" /db_xref="InterPro:IPR007383" /db_xref="InterPro:IPR016991" /db_xref="SubtiList:BG13034" /db_xref="UniProtKB/Swiss-Prot:O07543" /translation="MGIAGTFIFMIVIGAAIGAVTNHLAIQMLFRPYKAYYLFGKRVP FTPGLIPRRRDELAKQMGLMVVNHLLTPEGIKKRLVSDAAKTQALRVGEQLIQKLSLS EVTVKEALEKAGMKRPEKAADAWISSWTDDKLHELFRQYGDQSLKELVPIEVQEKLEE KIPMISGYILSRSVRYFESDEGKIRLGNMIDDFLKERGMLGSMVQLFLGNSSLADRVL PELLKFLRNEETNKLLSDLLKNEWGKLREYTFNEADEKWNAKALIFSLKRRVLQAFST APFFNNTIGTLTVRYESELTQQMLPALLDKLLEGISSNLESVLKRLRLEEIVKEQVDQ FPVERLEEMVLSISKKEFKMITYLGGLLGGIIGAIQALFVILF*" /label="yheB CDS" gene 1003097..1004230 /gene="yheB" /locus_tag="BSU_09790" /old_locus_tag="BSU09790" /label="yheB gene" S_feature 1004231..1004322 /Source="Nicolas_S_feature" /locus_tag="new_1054654_1054745" /HighExp="S4, S5, S6, BT, S3, S7, dia15, B36, G/S, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S344" CDS 1004323..1004676 /gene="yheA" /locus_tag="BSU_09800" /old_locus_tag="BSU09800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 19429628, 22720735" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388861.1" /db_xref="EnsemblGenomes-Gn:BSU09800" /db_xref="EnsemblGenomes-Tr:CAB12819" /db_xref="InterPro:IPR010368" /db_xref="InterPro:IPR023378" /db_xref="PDB:2OEE" /db_xref="SubtiList:BG13033" /db_xref="UniProtKB/Swiss-Prot:O07542" /translation="MAVNFYDVAYDLENALRGSEEFTRLKNLYDEVNADESAKRMFEN FRDVQLRLQQKQMAGEEITQEEVTQAQKTVALVQQHEKISQLMEAEQRMSMLIGELNK IIMKPLEELYGSVEG*" /label="yheA CDS" gene 1004323..1004676 /gene="yheA" /locus_tag="BSU_09800" /old_locus_tag="BSU09800" /label="yheA gene" downshifts 1004664 /Source="Nicolas_upshifts" /id="D522" /incds=0 /nref=159 /ntot=259 /MaxReadThrough="1.55668" /MaxDrop="5.9901" /score="24.5275597" /energy="-12.3" /TU="NA" /idTUdmin="U780" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1004720..1005793) /gene="yhaZ" /locus_tag="BSU_09810" /old_locus_tag="BSU09810" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16267290, 22933559" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388862.1" /db_xref="EnsemblGenomes-Gn:BSU09810" /db_xref="EnsemblGenomes-Tr:CAB12820" /db_xref="GOA:O07541" /db_xref="InterPro:IPR011989" /db_xref="InterPro:IPR014825" /db_xref="InterPro:IPR016024" /db_xref="InterPro:IPR021133" /db_xref="SubtiList:BG13002" /db_xref="UniProtKB/Swiss-Prot:O07541" /translation="MADLKEIYNEELISQLIHHVRSSYPDFNKNRFLDTLRLEDWPEL TLKERMRRVTVSLYETLPKQYVEALTILRDTAPHFKGLSGILFPDYVEQYGLAHWEES IKALESFTQYSTSEFAVRPFLLLDQEKMIAQLLAWSEHKNEHVRRLASEGSRPRLPWG KSIPALKSDPSPVLPILEKLMQDESLYVRKSVANNLNDISKTHPHLLRKVADQWYGTH PHTDWIIKHAYRTLLKKGDKQALALFGYENADSIQLHDLTCQPKRIVIGESLEFSFYI HSDRDQKVRIEYAIDFVKARGQRHQKVFKITETNIRKNETKSYTRIQSFKDLTTRKHY KGIHTLSVIINGEVKDSLDFQVC*" /label="yhaZ CDS" gene complement(1004720..1005793) /gene="yhaZ" /locus_tag="BSU_09810" /old_locus_tag="BSU09810" /label="yhaZ gene" downshifts complement(1004827) /Source="Nicolas_upshifts" /id="D523" /incds=1 /nref=16 /ntot=173 /MaxReadThrough="3.78071" /MaxDrop="3.586" /score="4.43596345" /energy="-12.3" /TU="U781" /idTUdmin="U781" /TUdmin="-109" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1005815..1005834) /Source="Nicolas_upshift_promotors" /id="U781" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig=1 /xcortree=2090 /SigmaFactorBS="ggtaggatcagttgttaatttttaggactataCACTTGATcc agaacgtacatTCCCATACAATATAAATAATaaacgaaaaagcggtgtttatatggct g" /listShort="yhaZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1005827) /Source="Nicolas_upshifts" /id="U781" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig=1 /xcortree=2090 /SigmaFactorBS="ggtaggatcagttgttaatttttaggactataCACTTGATcc agaacgtacatTCCCATACAATATAAATAATaaacgaaaaagcggtgtttatatggct g" /listShort="yhaZ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1005848..1005855) /Source="Nicolas_upshift_promotors" /id="U781" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93006993006993" /psig=1 /xcortree=2090 /SigmaFactorBS="ggtaggatcagttgttaatttttaggactataCACTTGATcc agaacgtacatTCCCATACAATATAAATAATaaacgaaaaagcggtgtttatatggct g" /listShort="yhaZ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1005930..1005937 /Source="Nicolas_upshift_promotors" /id="U782" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.882117882117882" /psig=1 /xcortree=344 /SigmaFactorBS="ggatatacaaaagttggttactttttttagttaaaaaaacCC TTGTCAtcggaaaggaaaacTGAGATAATAACATTGAAAGcgcctacacttacctatt t" /listShort="S345, S346, yhaX" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1005950 /Source="Nicolas_upshifts" /id="U782" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.882117882117882" /psig=1 /xcortree=344 /SigmaFactorBS="ggatatacaaaagttggttactttttttagttaaaaaaacCC TTGTCAtcggaaaggaaaacTGAGATAATAACATTGAAAGcgcctacacttacctatt t" /listShort="S345, S346, yhaX" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1005952..1005971 /Source="Nicolas_upshift_promotors" /id="U782" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.882117882117882" /psig=1 /xcortree=344 /SigmaFactorBS="ggatatacaaaagttggttactttttttagttaaaaaaacCC TTGTCAtcggaaaggaaaacTGAGATAATAACATTGAAAGcgcctacacttacctatt t" /listShort="S345, S346, yhaX" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1005961..1006114 /Source="Nicolas_S_feature" /locus_tag="new_1056384_1056537" /HighExp="M9-stat, BC, T0.30H, T1.30H, Lbstat, T1.0H, T3.30H, T2.0H, T3.0H, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S345" downshifts 1006071 /Source="Nicolas_upshifts" /id="D524" /incds=0 /nref=1 /ntot=37 /MaxReadThrough="7.40404" /MaxDrop="2.6506" /score="-6.05745557" /energy="-4.8" /TU="U782" /idTUdmin="U782" /TUdmin="-1056" /isTUend="FALSE" /label="downshifts" S_feature 1006116..1006199 /Source="Nicolas_S_feature" /locus_tag="new_1056539_1056622" /HighExp="M9-stat, B60, T2.0H, T1.30H, T0.30H, T2.30H, T3.0H, T1.0H, Lbtran, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S346" downshifts 1006156 /Source="Nicolas_upshifts" /id="D525" /incds=0 /nref=70 /ntot=231 /MaxReadThrough="4.88371" /MaxDrop="4.4099" /score="-6.05745557" /energy="-4.8" /TU="U782" /idTUdmin="U782" /TUdmin="-971" /isTUend="FALSE" /label="downshifts" promotor_-35 1006212..1006217 /Source="Nicolas_upshift_promotors" /id="U783" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1164 /SigmaFactorBS="gccaggctttttttgctttaagaaaaggttGTTCTAaacaca gagacagggTCATATCCTATACACAAGTacagtcatcaaggagggggacatctctgtg t" /listShort="yhaX, hemZ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1006233..1006251 /Source="Nicolas_upshift_promotors" /id="U783" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1164 /SigmaFactorBS="gccaggctttttttgctttaagaaaaggttGTTCTAaacaca gagacagggTCATATCCTATACACAAGTacagtcatcaaggagggggacatctctgtg t" /listShort="yhaX, hemZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1006242 /Source="Nicolas_upshifts" /id="U783" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1164 /SigmaFactorBS="gccaggctttttttgctttaagaaaaggttGTTCTAaacaca gagacagggTCATATCCTATACACAAGTacagtcatcaaggagggggacatctctgtg t" /listShort="yhaX, hemZ" /GFF_Attribute="listLong" /label="upshifts" CDS 1006279..1007145 /gene="yhaX" /locus_tag="BSU_09830" /old_locus_tag="BSU09830" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11988534; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_388864.2" /db_xref="EnsemblGenomes-Gn:BSU09830" /db_xref="EnsemblGenomes-Tr:CAB12822" /db_xref="GOA:O07539" /db_xref="InterPro:IPR000150" /db_xref="InterPro:IPR006379" /db_xref="InterPro:IPR036412" /db_xref="PDB:3DNP" /db_xref="SubtiList:BG13000" /db_xref="UniProtKB/Swiss-Prot:O07539" /translation="MSKQLLALNIDGALLRSNGKIHQATKDAIEYVKKKGIYVTLVTN RHFRSAQKIAKSLKLDAKLITHSGAYIAEKIDAPFFEKRISDDHTFNIVQVLESYQCN IRLLHEKYSIGNKKKVNSNLLGKALIHPSDPIFYPVQFVESLSDLLMDEPVSAPVIEV YTEHDIQHDITETITKAFPAVDVIRVNDEKLNIVPKGVSKEAGLALVASELGLSMDDV VAIGHQYDDLPMIELAGLGVAMGNAVPEIKRKADWVTRSNDEQGVAYMMKEYFRMQQR KGFLDKFHMKRV*" /label="yhaX CDS" gene 1006279..1007145 /gene="yhaX" /locus_tag="BSU_09830" /old_locus_tag="BSU09830" /label="yhaX gene" downshifts 1007127 /Source="Nicolas_upshifts" /id="D526" /incds=0 /nref=22 /ntot=67 /MaxReadThrough="3.99904" /MaxDrop="4.7771" /score="15.7706912" /energy="-16.6" /TU="U783" /idTUdmin="U782" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1007190..1007193 /Source="Nicolas_upshift_promotors" /id="U784" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.786213786213786" /psig=1 /xcortree=1455 /SigmaFactorBS="cgcgccctgacaggtgcggcggcttttttgccggATTGattt tagcagtttaTTTCTGTACACTAAAGAAAGttttgaatctgataaattaggtgatgaa g" /listShort="hemZ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1007208..1007227 /Source="Nicolas_upshift_promotors" /id="U784" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.786213786213786" /psig=1 /xcortree=1455 /SigmaFactorBS="cgcgccctgacaggtgcggcggcttttttgccggATTGattt tagcagtttaTTTCTGTACACTAAAGAAAGttttgaatctgataaattaggtgatgaa g" /listShort="hemZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1007216 /Source="Nicolas_upshifts" /id="U784" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.786213786213786" /psig=1 /xcortree=1455 /SigmaFactorBS="cgcgccctgacaggtgcggcggcttttttgccggATTGattt tagcagtttaTTTCTGTACACTAAAGAAAGttttgaatctgataaattaggtgatgaa g" /listShort="hemZ" /GFF_Attribute="listLong" /label="upshifts" CDS 1007257..1008762 /gene="hemZ" /locus_tag="BSU_09840" /old_locus_tag="BSU09840" /EC_number="1.3.99.-" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10498703, 21255303" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10498703, 21255303; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="coproporphyrinogen III oxidase" /protein_id="NP_388865.1" /db_xref="EnsemblGenomes-Gn:BSU09840" /db_xref="EnsemblGenomes-Tr:CAB12823" /db_xref="GOA:Q796V8" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR023995" /db_xref="InterPro:IPR034505" /db_xref="SubtiList:BG12999" /db_xref="UniProtKB/Swiss-Prot:Q796V8" /translation="MQIKIEGIHDDRLHRPLQNIANLFYEECELAYGGEEPADFVISL ALSQTDEHVTVSGEVKGTGIKEQHTKFFSPDMTEKEAFKQVKNTISYVYLNLLQAHTG ITQKWGILTGIRPTKLLHKKLQSGMSKEQAHAELKKDYLIHDEKIMLMQEIVDRQLAA VPDLYRVKDEVSIYIGIPFCPTKCAYCTFPAYAIQGQAGRVGSFLWGLHYEMQKIGEW LKEHDVKVTTIYFGGGTPTSITAEEMDLLYEEMVRSFPDVKNIREITVEAGRPDTITE EKLAVLNKYDIDRISINPQSYENETLKAIGRHHTVEETIEKYHLSRQHGMNNINMDLI IGLPGEGVKEFRHSLSETEKLMPESLTVHTLSFKRASEMTRNKHKYKVAGREEVSQMM EDAVAWTKEHGYVPYYLYRQKNILGNLENVGYSLPGQESIYNIMIMEEVQTIIGIGCG AASKFIDRDTGKITHFANPKDPKSYNERFEHYTDEKIKYLEQIFEKTTKQH*" /label="hemZ CDS" gene 1007257..1008762 /gene="hemZ" /locus_tag="BSU_09840" /old_locus_tag="BSU09840" /label="hemZ gene" downshifts 1008732 /Source="Nicolas_upshifts" /id="D527" /incds=0 /nref=113 /ntot=234 /MaxReadThrough="0.523269999999999" /MaxDrop="5.05369" /score="38.1573779" /energy="-14.4" /TU="NA" /idTUdmin="U783" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1008780..1009997) /gene="khtU" /locus_tag="BSU_09850" /old_locus_tag="BSU09850" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7934942, 14987767, 15849754, 15919996, 16850406, 24330391" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7934942, 14987767, 15849754, 15919996, 16850406, 24330391; Product type t : transporter" /codon_start=1 /transl_table=11 /product="proton/potassium antiporter; methylglyoxal resistance" /protein_id="NP_388866.2" /db_xref="EnsemblGenomes-Gn:BSU09850" /db_xref="EnsemblGenomes-Tr:CAB12825" /db_xref="GOA:O07536" /db_xref="InterPro:IPR006153" /db_xref="SubtiList:BG12997" /db_xref="UniProtKB/Swiss-Prot:O07536" /translation="MDHLVFEVGTALVLVAIASVIANKIKFSIIPFLIVLGMLVGPHA PKMGIIDLTFIQSSEIIEFFGRMGVLFLLFYLGLEFSVGKLIKSGKSIAVGGTIYILI NFSLGLLYGFITGFSFLEVLILAGVITISSSAIVAKVLVDLKRTANPETELILGIIMF EDIFLAVYLSVVSGLILGDATSVGSALLSILIAFGYMLLFFIAARKLPPLLNKLLDIR SNEVFIIVIFAALFFIAGFSETIHVAEAIGALLLGLVFSETEHSDRIEHLVVPFRDFF GAMFFFSFGLSIDPFSLGEAVWLALGAVILTILGNFIAGMVAGRRAGLSHKASSNIGL TIVSRGEFSIIVANLGIAGGLSATLKPFAALYVLILAILGPLVTKESKRIYRLLNKVF KWKPEVQPAKKQG*" /label="khtU CDS" gene complement(1008780..1009997) /gene="khtU" /locus_tag="BSU_09850" /old_locus_tag="BSU09850" /label="khtU gene" downshifts complement(1008786) /Source="Nicolas_upshifts" /id="D528" /incds=0 /nref=154 /ntot=249 /MaxReadThrough="1.74386" /MaxDrop="6.8685" /score="8.64654688" /energy="-14.4" /TU="NA" /idTUdmin="U785" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(1010004..1010501) /gene="khtT" /locus_tag="BSU_09860" /old_locus_tag="BSU09860" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:14987767, 17679694" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14987767, 17679694; Product type t: transporter" /codon_start=1 /transl_table=11 /product="K+/H+ antiporter for K+ efflux" /protein_id="NP_388867.1" /db_xref="EnsemblGenomes-Gn:BSU09860" /db_xref="EnsemblGenomes-Tr:CAB12826" /db_xref="GOA:O07535" /db_xref="InterPro:IPR006037" /db_xref="InterPro:IPR026278" /db_xref="InterPro:IPR036721" /db_xref="SubtiList:BG12996" /db_xref="UniProtKB/Swiss-Prot:O07535" /translation="MNIKENDLPGIGKKFEIETRSHEKMTIIIHDDGRREIYRFNDRD PDELLSNISLDDSEARQIAAILGGMVYKPQALESIEMAFSDLIIEWFKVEKGAKSIGR TLGELDVRQNYDVTVIAIIKHNQEKLLNPGADSIIEENDTLVLSGERKHLKKLIHDFL SGEGV*" /label="khtT CDS" gene complement(1010004..1010501) /gene="khtT" /locus_tag="BSU_09860" /old_locus_tag="BSU09860" /label="khtT gene" CDS complement(1010565..1010903) /gene="khtS" /locus_tag="BSU_09870" /old_locus_tag="BSU09870" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:14987767, 17679694" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14987767, 17679694; Product type t: transporter" /codon_start=1 /transl_table=11 /product="K+/H+ antiporter for K+ efflux" /protein_id="NP_388868.1" /db_xref="EnsemblGenomes-Gn:BSU09870" /db_xref="EnsemblGenomes-Tr:CAB12827" /db_xref="GOA:O07534" /db_xref="SubtiList:BG12995" /db_xref="UniProtKB/Swiss-Prot:O07534" /translation="MRREERNMDKLLISFLLSLFMVYFPPSDVVLPSQFEASTDSYVP MSSYPQETQSAKTPSPGSMHPAELIKEYSPLAQSVRQLSVKPLDEPLINRLEKALAVP VKYQSNYLRI*" /label="khtS CDS" gene complement(1010565..1010903) /gene="khtS" /locus_tag="BSU_09870" /old_locus_tag="BSU09870" /label="khtS gene" promotor_-10 complement(1010915..1010934) /Source="Nicolas_upshift_promotors" /id="U785" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig="0.97902097902098" /xcortree=628 /SigmaFactorBS="acctttttatttttcaaggtcaatagatactgaaaaatgcat atTGTTTGAAtggaaacataaagTTTTATATAGTGAAAAAGAAgggatatcttgatga g" /listShort="khtS, khtT, yhaU" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1010939) /Source="Nicolas_upshifts" /id="U785" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig="0.97902097902098" /xcortree=628 /SigmaFactorBS="acctttttatttttcaaggtcaatagatactgaaaaatgcat atTGTTTGAAtggaaacataaagTTTTATATAGTGAAAAAGAAgggatatcttgatga g" /listShort="khtS, khtT, yhaU" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1010948..1010955) /Source="Nicolas_upshift_promotors" /id="U785" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig="0.97902097902098" /xcortree=628 /SigmaFactorBS="acctttttatttttcaaggtcaatagatactgaaaaatgcat atTGTTTGAAtggaaacataaagTTTTATATAGTGAAAAAGAAgggatatcttgatga g" /listShort="khtS, khtT, yhaU" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1010975..1010982 /Source="Nicolas_upshift_promotors" /id="U786" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.825174825174825" /psig="0.971028971028971" /xcortree=364 /SigmaFactorBS="attcaaacaatatgcatttttcagtatcTATTGACCttgaaa aataaaaaGGTTTATTTGGGGATGGCGGggaatgtataggagaaagaaaaaagtaagc g" /listShort="yhaR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1010997..1011016 /Source="Nicolas_upshift_promotors" /id="U786" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.825174825174825" /psig="0.971028971028971" /xcortree=364 /SigmaFactorBS="attcaaacaatatgcatttttcagtatcTATTGACCttgaaa aataaaaaGGTTTATTTGGGGATGGCGGggaatgtataggagaaagaaaaaagtaagc g" /listShort="yhaR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1011007 /Source="Nicolas_upshifts" /id="U786" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.825174825174825" /psig="0.971028971028971" /xcortree=364 /SigmaFactorBS="attcaaacaatatgcatttttcagtatcTATTGACCttgaaa aataaaaaGGTTTATTTGGGGATGGCGGggaatgtataggagaaagaaaaaagtaagc g" /listShort="yhaR" /GFF_Attribute="listLong" /label="upshifts" CDS 1011068..1011835 /gene="yhaR" /locus_tag="BSU_09880" /old_locus_tag="BSU09880" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22961985; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dehydratase / isomerase" /protein_id="NP_388869.3" /db_xref="EnsemblGenomes-Gn:BSU09880" /db_xref="EnsemblGenomes-Tr:CAB12828" /db_xref="GOA:O07533" /db_xref="InterPro:IPR001753" /db_xref="InterPro:IPR014748" /db_xref="InterPro:IPR029045" /db_xref="SubtiList:BG12994" /db_xref="UniProtKB/Swiss-Prot:O07533" /translation="MEFVQYACNGAVAEIILNRPDAHHALNEQMLSELKEAVEMAAAS EALIVLLRGSGKGFSAGGDIRMMTSEHDPDQFKRLMDTIEAVTLNLYQMKKVTIAAIH GAAAGLGLSLALCADIVLAEKNAVLAMNFIGIGLVPDGGGHYLLKKRIGEAKAKKLIW SGKKLSASEAADMGLLDGTFAGDPAEGARPIIETLLASPLLAMIETKGIFQSLQIEEL KKVLSLERSAQERMRRTKDHQEGIRAFLEKREPKFQA*" /label="yhaR CDS" gene 1011068..1011835 /gene="yhaR" /locus_tag="BSU_09880" /old_locus_tag="BSU09880" /label="yhaR gene" downshifts 1011836 /Source="Nicolas_upshifts" /id="D529" /incds=0 /nref=2 /ntot=99 /MaxReadThrough="1.78111" /MaxDrop="4.66019" /score="-8.79921781" /energy="-7.5" /TU="NA" /idTUdmin="U786" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1011856..1012041) /gene="yhzD" /locus_tag="BSU_09889" /old_locus_tag="BSU09889" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097698.1" /db_xref="EnsemblGenomes-Gn:BSU09889" /db_xref="EnsemblGenomes-Tr:CAX52586" /db_xref="InterPro:IPR025544" /db_xref="UniProtKB/Swiss-Prot:C0H3Y1" /translation="MADYFLTVFDPSGNTLVNEQFEAEHEEAAKTHGEALLKEKELHS HTHRLVNAAGKLILFHR*" /label="yhzD CDS" gene complement(1011856..1012041) /gene="yhzD" /locus_tag="BSU_09889" /old_locus_tag="BSU09889" /label="yhzD gene" promotor_-10 complement(1012077..1012095) /Source="Nicolas_upshift_promotors" /id="U787" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.637362637362637" /psig="0.637362637362637" /xcortree=957 /SigmaFactorBS="acccattatatactaattttggataaagcataatAAAGGATT TtgatttccttTTTAGAATATAAATGAAGAaagactgataaaccttaaaatggaggag a" /listShort="yhzD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1012088) /Source="Nicolas_upshifts" /id="U787" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.637362637362637" /psig="0.637362637362637" /xcortree=957 /SigmaFactorBS="acccattatatactaattttggataaagcataatAAAGGATT TtgatttccttTTTAGAATATAAATGAAGAaagactgataaaccttaaaatggaggag a" /listShort="yhzD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1012106..1012114) /Source="Nicolas_upshift_promotors" /id="U787" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.637362637362637" /psig="0.637362637362637" /xcortree=957 /SigmaFactorBS="acccattatatactaattttggataaagcataatAAAGGATT TtgatttccttTTTAGAATATAAATGAAGAaagactgataaaccttaaaatggaggag a" /listShort="yhzD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1012115..1012118 /Source="Nicolas_upshift_promotors" /id="U788" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.797202797202797" /psig="0.974025974025974" /xcortree=2418 /SigmaFactorBS="tttatattctaaaaaggaaatcaaaatcctttATTAtgcttt atccaaaaTTAGTATATAATGGGTCAGGgaaggaggagattcagtgcttacaattgat c" /listShort="natA, natB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1012133..1012152 /Source="Nicolas_upshift_promotors" /id="U788" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.797202797202797" /psig="0.974025974025974" /xcortree=2418 /SigmaFactorBS="tttatattctaaaaaggaaatcaaaatcctttATTAtgcttt atccaaaaTTAGTATATAATGGGTCAGGgaaggaggagattcagtgcttacaattgat c" /listShort="natA, natB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1012143 /Source="Nicolas_upshifts" /id="U788" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.797202797202797" /psig="0.974025974025974" /xcortree=2418 /SigmaFactorBS="tttatattctaaaaaggaaatcaaaatcctttATTAtgcttt atccaaaaTTAGTATATAATGGGTCAGGgaaggaggagattcagtgcttacaattgat c" /listShort="natA, natB" /GFF_Attribute="listLong" /label="upshifts" CDS 1012168..1013064 /gene="yhaQ" /locus_tag="BSU_09890" /old_locus_tag="BSU09890" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9106203, 10356997, 12374817; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Na+-dependent efflux ABC transporter (ATP-binding protein)" /protein_id="NP_388870.2" /db_xref="EnsemblGenomes-Gn:BSU09890" /db_xref="EnsemblGenomes-Tr:CAB12829" /db_xref="GOA:C0SPB4" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR025302" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12993" /db_xref="UniProtKB/Swiss-Prot:C0SPB4" /translation="MLTIDHVTKTFGDYKAVDGLDLDIPEQQMFGLLGANGAGKTTTF RMILGLLSITEGSISWKGRPVNYHISNKIGYLPEERGLYPKMKVRDQLVYLARLKGME KREAVKELGTWLERFNITDYENKKVEELSKGNQQKIQFISAVLHKPELLILDEPFSGL DPVNVELLKEAVISLKNSGVSILFSSHRMEHVEELCENLCILQKGKPVVQGKLKEIKR SFGKKNVTIHSDDDLRFLQSHEGILQWKETADGVKLQIANEDISQEIFAMLQGKGFIR KFELEEPSLHDIFIEKVGAVYE*" /label="yhaQ CDS" gene 1012168..1013064 /gene="yhaQ" /locus_tag="BSU_09890" /old_locus_tag="BSU09890" /label="yhaQ gene" CDS 1013057..1014316 /gene="yhaP" /locus_tag="BSU_09900" /old_locus_tag="BSU09900" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9106203, 10356997, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Na+-dependent exporter (ABC permease)" /protein_id="NP_388871.2" /db_xref="EnsemblGenomes-Gn:BSU09900" /db_xref="EnsemblGenomes-Tr:CAB12830" /db_xref="GOA:O07523" /db_xref="SubtiList:BG12992" /db_xref="UniProtKB/Swiss-Prot:O07523" /translation="MNKFWIMLSHTYKNKIMAKSFIISTVITVLLVLVVTNLESIISL FQGDDAKEKIAVVDETNELYPVFSKQLKAVDTDGDLDVKLSKQSEDEVTKQVKDESLD GMLIIKRDEKGTISGTYKALTISDESTYQTLQQALTQTKTAVGTAELGVSQETISSLY APVTVGQKALKEGAKSEEELGQTVGLVYIMLFVIYFSVIMYASMIAMEVATEKSSRVM EILISSMPPIQQMFAKLLGIGLVGITQLAIIIGAGSLSLKLNQKSETASSVGGFLNLT DVSATTVIYAVIFFLLGYFLYATLAAFLGSVVSRIEDVQQTITPMTLLVVAGFMIAMF GLNAPDAGFITVTSFIPFFTPMIMFLRVGMLDIPFWQAAVGIGITLLTIVILAVIGAR IYKGGVLIYGNSSAFKAIKQALRLAKN*" /label="yhaP CDS" gene 1013057..1014316 /gene="yhaP" /locus_tag="BSU_09900" /old_locus_tag="BSU09900" /label="yhaP gene" downshifts 1014300 /Source="Nicolas_upshifts" /id="D530" /incds=0 /nref=19 /ntot=187 /MaxReadThrough="2.50232" /MaxDrop="3.26822" /score="8.93460501" /energy="-12.8" /TU="NA" /idTUdmin="U788" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1014364..1014371 /Source="Nicolas_upshift_promotors" /id="U789" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.682317682317682" /psig="0.998001998001998" /xcortree=2088 /SigmaFactorBS="cctggggattctcaggctgtttctttattgacagaaCGTGCA TTcgcaagaattcGGTGCTAAAATAAGGGTACTtcatcctggaaaggagcagaatgtt g" /listShort="yhaO, yhaN, yhaM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1014383..1014402 /Source="Nicolas_upshift_promotors" /id="U789" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.682317682317682" /psig="0.998001998001998" /xcortree=2088 /SigmaFactorBS="cctggggattctcaggctgtttctttattgacagaaCGTGCA TTcgcaagaattcGGTGCTAAAATAAGGGTACTtcatcctggaaaggagcagaatgtt g" /listShort="yhaO, yhaN, yhaM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1014388 /Source="Nicolas_upshifts" /id="U789" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.682317682317682" /psig="0.998001998001998" /xcortree=2088 /SigmaFactorBS="cctggggattctcaggctgtttctttattgacagaaCGTGCA TTcgcaagaattcGGTGCTAAAATAAGGGTACTtcatcctggaaaggagcagaatgtt g" /listShort="yhaO, yhaN, yhaM" /GFF_Attribute="listLong" /label="upshifts" CDS 1014423..1015649 /gene="yhaO" /locus_tag="BSU_09910" /old_locus_tag="BSU09910" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16267290; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative DNA repair exonuclease" /protein_id="NP_388872.1" /db_xref="EnsemblGenomes-Gn:BSU09910" /db_xref="EnsemblGenomes-Tr:CAB12831" /db_xref="GOA:O07522" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR014576" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG12991" /db_xref="UniProtKB/Swiss-Prot:O07522" /translation="MLTDLTFIHAADLHLDSPFYGISHLPEPIFARIKESTFASVRHM IDAAVREHVDFILLAGDLFDEANRSLKAQLFLKKQFERLRECGISVYVIFGNHDHLGG EWTPIEWPENVHIFSSAVPEEKSFFKEGRRIASIYGFSYQARALMENQAARYRRSTDA PFHIGMLHGTLSGSEGHDPYCPFTHDDLVKSGMDYWALGHIHKRQVLSAEHPAVIYPG NTQARHIKETGDKGYYLVHVTNGDISYEFQRAHDVLWEKAAVDVTEAKNMTALFQMVE DTFSKLRKKGSPVCVRLVLQGTAPEWLLEAPKGTLDEFLEALQEQEAEEERFVWPLRL DDETENEANLTNLDPFFGGLFEDIDRSDLSDVLEGLERHPVYRRHADRFSQEEVKEIK EQAQIILKRQLKVLDT*" /label="yhaO CDS" gene 1014423..1015649 /gene="yhaO" /locus_tag="BSU_09910" /old_locus_tag="BSU09910" /label="yhaO gene" downshifts complement(1015124) /Source="Nicolas_upshifts" /id="D531" /incds=1 /nref=1 /ntot=20 /MaxReadThrough="0.0165100000000002" /MaxDrop="3.62411" /score="-5.83060322" /energy="-15.2" /TU="NA" /idTUdmin="U787" /TUdmin="-3300" /isTUend="FALSE" /label="downshifts" CDS 1015654..1018545 /gene="sbcE" /locus_tag="BSU_09920" /old_locus_tag="BSU09920" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16267290, 19906728, 21517913" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16267290, 19906728, 21517913; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATPase involved in DNA double strand break repair and recombination" /protein_id="NP_388873.1" /db_xref="EnsemblGenomes-Gn:BSU09920" /db_xref="EnsemblGenomes-Tr:CAB12832" /db_xref="GOA:O08455" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12990" /db_xref="UniProtKB/Swiss-Prot:O08455" /translation="MTALRIISLHIYQYGKFSNRTFDFSASPVQVIYGLNEAGKTTMM SFIESMLFGFPKTKKYEPKTGGVYGGVLEAEHPEYGVLKIERTKGTAEKLSVYTEKGE VKQGDVLKQLFQGTDRSLYKAIYSFDVFGLQEIHAFNRDKIGEFLLFSSLFGAEAVSK LDSRLTKESERLYKPNGRNPQLNQELETLKQLAVKLKQAEAEEAGYHQLLEEKRTLEA RLAAAETELKETAGHIRMIEGAIERKPLLNEKATLEQVIAEFPEHAGQFPADGLHQLE KYESHLHPKSAQLEALRVKMAELDKQRQKLIPDKELLAKETLIQELSAAFHMYQSWGE QLAAIQAQLRQTSAQTAAGLEQLNKTDENELLNMNTSYDYEWQLQQAVQQYVQARDRK RQLDETFELARQELEDAEKAVRAASSAILENSQRKDKEAALRAYDETQGQHQEQAKLR EQLTFFERQQAKQKKTVIAAGMLFIVLFSLLQQWIPAISFGAALIVYWLVSGKSSSRN SRETRQPMTDISPAEAEMLREALWEDDRNKQHLLTQRAALQQKEAAYERVIQQFEQWE AEMAPSFTQVERFMNELGFKEDPSFLLDAYSLMKDVKKEVKKKHELTIEAGRLKKHRR TFEERVSMLLPVNQSQDISISDALHTLRKNIEREKEIEKQKKEIETDIHYTKEQMLEL EQEIQYFHAQIEQLFAAAAAKDRDAFFAIAAISRQLKDTENKLHHVNAQLQGGYPEEL ELADSNTLSELKDKQFVENERKERLTEEIEQLRSQIALLSVKQEQLEASGMVSDLKLQ TEMQKERVKETAKKWASIQMVKQVIRNKLERHKKIELPRLLETAGEFFRPLTDGNYQT IYFSETDDSIMVMHRDGTVYHAEELSQGTCEQLYTAIRFALAVTRQGESKLPFQLDDS FVHFDQERLKRVLHVLYDLSEGGRQILYFTCHEHVKDAFHSSQIIHLVS*" /label="sbcE CDS" gene 1015654..1018545 /gene="sbcE" /locus_tag="BSU_09920" /old_locus_tag="BSU09920" /label="sbcE gene" promotor_-35 1016935..1016940 /Source="Nicolas_upshift_promotors" /id="U790" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=796 /SigmaFactorBS="tcgtccgcgattcttgaaaacagccaaagaaaaGATAAAgaa gcagctcttagaGCATATGATGAAACACAGGggcagcaccaagagcaagcgaagctca g" /listShort="yhaM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1016956..1016974 /Source="Nicolas_upshift_promotors" /id="U790" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=796 /SigmaFactorBS="tcgtccgcgattcttgaaaacagccaaagaaaaGATAAAgaa gcagctcttagaGCATATGATGAAACACAGGggcagcaccaagagcaagcgaagctca g" /listShort="yhaM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1016962 /Source="Nicolas_upshifts" /id="U790" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=796 /SigmaFactorBS="tcgtccgcgattcttgaaaacagccaaagaaaaGATAAAgaa gcagctcttagaGCATATGATGAAACACAGGggcagcaccaagagcaagcgaagctca g" /listShort="yhaM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1018553..1018558 /Source="Nicolas_upshift_promotors" /id="U791" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.420579420579421" /psig="0.998001998001998" /xcortree=2174 /SigmaFactorBS="atccatttggtgtcataaaagaggtTCTATAgctgaaaatcg gtaTGTGATATACTGGTATTATGtaagatacggagggagctttaatagaatggctaaa g" /listShort="yhaM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1018573..1018592 /Source="Nicolas_upshift_promotors" /id="U791" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.420579420579421" /psig="0.998001998001998" /xcortree=2174 /SigmaFactorBS="atccatttggtgtcataaaagaggtTCTATAgctgaaaatcg gtaTGTGATATACTGGTATTATGtaagatacggagggagctttaatagaatggctaaa g" /listShort="yhaM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1018588 /Source="Nicolas_upshifts" /id="U791" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.420579420579421" /psig="0.998001998001998" /xcortree=2174 /SigmaFactorBS="atccatttggtgtcataaaagaggtTCTATAgctgaaaatcg gtaTGTGATATACTGGTATTATGtaagatacggagggagctttaatagaatggctaaa g" /listShort="yhaM" /GFF_Attribute="listLong" /label="upshifts" CDS 1018619..1019563 /gene="yhaM" /locus_tag="BSU_09930" /old_locus_tag="BSU09930" /EC_number="3.1.-.-" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12399495, 15805522, 15983136, 16267290, 19553197, 19880604" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12399495, 15805522, 15983136, 16267290, 19553197, 19880604; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="3'-5' exonuclease" /protein_id="NP_388874.1" /db_xref="EnsemblGenomes-Gn:BSU09930" /db_xref="EnsemblGenomes-Tr:CAB12833" /db_xref="GOA:O07521" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR006674" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR020873" /db_xref="SubtiList:BG12989" /db_xref="UniProtKB/Swiss-Prot:O07521" /translation="MAKGIMLHEVGEQVDQYLLIKSSTKGIASNGKPFLTLMLQDQSG DIEAKLWDAKQSDEVTYAPQTIVKVVGDVHHYRGRTQLKLRNIRPVSEQENVNIDDFL ETAPIPKNEMMDTITQYIFEMKNPNIQRITRFLVKKHEAEFMDYPAATKNHHEFVSGL AYHVVSMLNLAKAIADLYPSLDRDLLYAGVILHDLGKVKELSGPVSTSYTVEGNLLGH ISIMVTELSKAAEELQIDSEEVLILQHLILSHHGKAEWGSPKPPMVKEAEILHYIDNL DAKMNMMDRALERVKPGEYTERVFALENRSFYKPTFHK*" /label="yhaM CDS" gene 1018619..1019563 /gene="yhaM" /locus_tag="BSU_09930" /old_locus_tag="BSU09930" /label="yhaM gene" downshifts 1019541 /Source="Nicolas_upshifts" /id="D532" /incds=0 /nref=183 /ntot=261 /MaxReadThrough="3.02818" /MaxDrop="5.88173" /score="6.06919899" /energy="-15.8" /TU="NA" /idTUdmin="U789" /TUdmin=5 /isTUend="TRUE" /label="downshifts" promotor_-35 1019622..1019627 /Source="Nicolas_upshift_promotors" /id="U792" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1159 /SigmaFactorBS="atattcagctcagtcctttttgatgcgtctttcccgCACATA actcgtctcattcccGCATATGGTTAAGAATAAAgaatctatgcaaagggggaggagc c" /listShort="yhaL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1019643..1019661 /Source="Nicolas_upshift_promotors" /id="U792" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1159 /SigmaFactorBS="atattcagctcagtcctttttgatgcgtctttcccgCACATA actcgtctcattcccGCATATGGTTAAGAATAAAgaatctatgcaaagggggaggagc c" /listShort="yhaL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1019646 /Source="Nicolas_upshifts" /id="U792" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1159 /SigmaFactorBS="atattcagctcagtcctttttgatgcgtctttcccgCACATA actcgtctcattcccGCATATGGTTAAGAATAAAgaatctatgcaaagggggaggagc c" /listShort="yhaL" /GFF_Attribute="listLong" /label="upshifts" CDS 1019688..1019900 /gene="yhaL" /locus_tag="BSU_09940" /old_locus_tag="BSU09940" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:14523133" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14523133; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="sporulation factor" /protein_id="NP_388875.1" /db_xref="EnsemblGenomes-Gn:BSU09940" /db_xref="EnsemblGenomes-Tr:CAB12834" /db_xref="GOA:O07520" /db_xref="InterPro:IPR025428" /db_xref="SubtiList:BG12988" /db_xref="UniProtKB/Swiss-Prot:O07520" /translation="MLFFPWWVYLCIVGIIFSAYKLVAAAKEEEKVDQAFIEKEGQIY MERMEKERERRSSQQHEEENQNHSIA*" /label="yhaL CDS" gene 1019688..1019900 /gene="yhaL" /locus_tag="BSU_09940" /old_locus_tag="BSU09940" /label="yhaL gene" downshifts 1019893 /Source="Nicolas_upshifts" /id="D533" /incds=0 /nref=8 /ntot=158 /MaxReadThrough="2.03283" /MaxDrop="6.60832" /score="62.1892984" /energy="-22" /TU="NA" /idTUdmin="U792" /TUdmin=5 /isTUend="TRUE" /label="downshifts" downshifts complement(1019931) /Source="Nicolas_upshifts" /id="D534" /incds=0 /nref=97 /ntot=260 /MaxReadThrough="0.90997" /MaxDrop="9.00938" /score="52.3375501" /energy="-22" /TU="NA" /idTUdmin="U793" /TUdmin=11 /isTUend="TRUE" /label="downshifts" CDS complement(1019941..1020819) /gene="prsA" /locus_tag="BSU_09950" /old_locus_tag="BSU09950" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12634326, 12682299, 14976191, 16516208, 25525259, 26711778" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12634326, 12682299, 14976191, 16516208, 25525259, 26711778; Product type lp : lipoprotein" /codon_start=1 /transl_table=11 /product="molecular chaperone lipoprotein" /protein_id="NP_388876.1" /db_xref="EnsemblGenomes-Gn:BSU09950" /db_xref="EnsemblGenomes-Tr:CAB12835" /db_xref="GOA:P24327" /db_xref="InterPro:IPR000297" /db_xref="InterPro:IPR008880" /db_xref="InterPro:IPR023058" /db_xref="InterPro:IPR023059" /db_xref="InterPro:IPR027304" /db_xref="PDB:1ZK6" /db_xref="PDB:4WO7" /db_xref="SubtiList:BG10464" /db_xref="UniProtKB/Swiss-Prot:P24327" /translation="MKKIAIAAITATSILALSACSSGDKEVIAKTDAGDVTKGELYTN MKKTAGASVLTQLVQEKVLDKKYKVSDKEIDNKLKEYKTQLGDQYTALEKQYGKDYLK EQVKYELLTQKAAKDNIKVTDADIKEYWEGLKGKIRASHILVADKKTAEEVEKKLKKG EKFEDLAKEYSTDSSASKGGDLGWFAKEGQMDETFSKAAFKLKTGEVSDPVKTQYGYH IIKKTEERGKYDDMKKELKSEVLEQKLNDNAAVQEAVQKVMKKADIEVKDKDLKDTFN TSSTSNSTSSSSSNSK*" /label="prsA CDS" gene complement(1019941..1020819) /gene="prsA" /locus_tag="BSU_09950" /old_locus_tag="BSU09950" /label="prsA gene" downshifts complement(1020129) /Source="Nicolas_upshifts" /id="D535" /incds=1 /nref=10 /ntot=127 /MaxReadThrough="7.54458" /MaxDrop="3.5906" /score="52.3375501" /energy="-22" /TU="U793" /idTUdmin="U793" /TUdmin="-187" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1020857..1020876) /Source="Nicolas_upshift_promotors" /id="U793" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.565434565434565" /psig="0.996003996003996" /xcortree=1995 /SigmaFactorBS="gtcatcagcaaaagtttgactagacgaatgccctttatttaa aaTCTTTTTAcagaaagccacaaTATGTTATGATACGCATAGGtaatttaatttggaa t" /listShort="prsA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1020881) /Source="Nicolas_upshifts" /id="U793" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.565434565434565" /psig="0.996003996003996" /xcortree=1995 /SigmaFactorBS="gtcatcagcaaaagtttgactagacgaatgccctttatttaa aaTCTTTTTAcagaaagccacaaTATGTTATGATACGCATAGGtaatttaatttggaa t" /listShort="prsA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1020890..1020897) /Source="Nicolas_upshift_promotors" /id="U793" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.565434565434565" /psig="0.996003996003996" /xcortree=1995 /SigmaFactorBS="gtcatcagcaaaagtttgactagacgaatgccctttatttaa aaTCTTTTTAcagaaagccacaaTATGTTATGATACGCATAGGtaatttaatttggaa t" /listShort="prsA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1020917..1020926 /Source="Nicolas_upshift_promotors" /id="U794" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1349 /SigmaFactorBS="tgtggctttctgtaaaaagattttaaataaagggcattcGTC TAGTCAAacttttgctgatGACATACTTATATATTGATCaagaaaaggaggtatgtaa c" /listShort="yhzE, S347, S349" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1020938 /Source="Nicolas_upshifts" /id="U794" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1349 /SigmaFactorBS="tgtggctttctgtaaaaagattttaaataaagggcattcGTC TAGTCAAacttttgctgatGACATACTTATATATTGATCaagaaaaggaggtatgtaa c" /listShort="yhzE, S347, S349" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1020939..1020958 /Source="Nicolas_upshift_promotors" /id="U794" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1349 /SigmaFactorBS="tgtggctttctgtaaaaagattttaaataaagggcattcGTC TAGTCAAacttttgctgatGACATACTTATATATTGATCaagaaaaggaggtatgtaa c" /listShort="yhzE, S347, S349" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1020975..1020989) /Source="Nicolas_upshift_promotors" /id="U795" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=700 /SigmaFactorBS="taagcaaaatgaacagtactacgagcaacgcgaaTCCGTtag agtatCCTCCGCTCATGTTAcatacctccttttcttgatcaatatataagtatgtcat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1020976) /Source="Nicolas_upshifts" /id="U795" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=700 /SigmaFactorBS="taagcaaaatgaacagtactacgagcaacgcgaaTCCGTtag agtatCCTCCGCTCATGTTAcatacctccttttcttgatcaatatataagtatgtcat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 1020979..1021065 /gene="sscA" /locus_tag="BSU_09958" /old_locus_tag="BSU09958" /function="15.7: Sporulation and germination" /experiment="publication(s) with functional evidences, PMID:20156992, 21670523" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20156992, 21670523; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="spore assembly and germination protein" /protein_id="YP_003097699.1" /db_xref="EnsemblGenomes-Gn:BSU09958" /db_xref="EnsemblGenomes-Tr:CAX52587" /db_xref="GOA:C0H3Y2" /db_xref="InterPro:IPR010070" /db_xref="UniProtKB/Swiss-Prot:C0H3Y2" /translation="MSGGYSNGFALLVVLFILLIIVGAAYIY*" /label="sscA CDS" gene 1020979..1021065 /gene="sscA" /locus_tag="BSU_09958" /old_locus_tag="BSU09958" /label="sscA gene" promotor_-35 complement(1020998..1021002) /Source="Nicolas_upshift_promotors" /id="U795" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=700 /SigmaFactorBS="taagcaaaatgaacagtactacgagcaacgcgaaTCCGTtag agtatCCTCCGCTCATGTTAcatacctccttttcttgatcaatatataagtatgtcat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1021066..1021317 /Source="Nicolas_S_feature" /locus_tag="new_1071489_1071740" /HighExp="S8, S7, S6, BT, G/S, B36, Pyr, S5, B60, Glucon" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba=1 /TUshortSig="SigK" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S347" CDS 1021190..1021276 /gene="sscB" /locus_tag="BSU_09959" /old_locus_tag="BSU09959" /function="15.7: Sporulation and germination" /experiment="publication(s) with functional evidences, PMID:21670523" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21670523; Product type f: factor" /codon_start=1 /transl_table=11 /product="spore and germination protein" /protein_id="YP_009513948.1" /db_xref="EnsemblGenomes-Gn:BSU09959" /db_xref="EnsemblGenomes-Tr:CCQ48595" /db_xref="GOA:L8EBJ6" /db_xref="InterPro:IPR010070" /db_xref="UniProtKB/TrEMBL:L8EBJ6" /translation="MGEVFAGGFALLVVLFILLIIIGASWLY*" /label="sscB CDS" gene 1021190..1021276 /gene="sscB" /locus_tag="BSU_09959" /old_locus_tag="BSU09959" /label="sscB gene" downshifts 1021274 /Source="Nicolas_upshifts" /id="D536" /incds=0 /nref=28 /ntot=50 /MaxReadThrough="4.67734" /MaxDrop="4.7906" /score="14.3797211" /energy="-17.6" /TU="U794" /idTUdmin="U794" /TUdmin="-506" /isTUend="FALSE" /label="downshifts" S_feature complement(1021286..1021548) /Source="Nicolas_S_feature" /locus_tag="new_1071709_1071971_c" /HighExp="LBGtran, LBGstat, LPhT, LBGexp, HPh, dia15, T0.30H, dia0, G180, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 0.995" /TUlongSig="SigA" /TUlongPSig="0.989" /label="S348" S_feature 1021319..1021802 /Source="Nicolas_S_feature" /locus_tag="new_1071742_1072225" /HighExp="S8, S6, S7, BT, C30, S5, Pyr, Glucon, G/S, C90" /AntisenseName="yhaJ" /AntisenseCor="-0.22462434208606599" /AntisenseRegPval="-3.7" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S349" downshifts complement(1021329) /Source="Nicolas_upshifts" /id="D537" /incds=0 /nref=153 /ntot=265 /MaxReadThrough="1.32339" /MaxDrop="6.55635" /score="34.7913848" /energy="-17.6" /TU="NA" /idTUdmin="U796" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1021541..1021560) /Source="Nicolas_upshift_promotors" /id="U796" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.58041958041958" /psig="0.999000999001" /xcortree=2759 /SigmaFactorBS="gtgctggtggcgatttttcaatttgcattCTATCTtttttaa taaataTTTGGTAATGTAATATGGGAcagttcagagagagggggaatctcccatcatt t" /listShort="S348" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1021548) /Source="Nicolas_upshifts" /id="U796" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.58041958041958" /psig="0.999000999001" /xcortree=2759 /SigmaFactorBS="gtgctggtggcgatttttcaatttgcattCTATCTtttttaa taaataTTTGGTAATGTAATATGGGAcagttcagagagagggggaatctcccatcatt t" /listShort="S348" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1021550..1021618) /Source="Nicolas_S_feature" /locus_tag="new_1071973_1072041_c" /HighExp="Paraq, G180, C30, LBGexp, Oxctl, G135, Lbexp, Heat, G150, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.29568499999999998" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="SigA" /TUlongPSig="0.989" /label="S350" promotor_-35 complement(1021574..1021579) /Source="Nicolas_upshift_promotors" /id="U796" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.58041958041958" /psig="0.999000999001" /xcortree=2759 /SigmaFactorBS="gtgctggtggcgatttttcaatttgcattCTATCTtttttaa taaataTTTGGTAATGTAATATGGGAcagttcagagagagggggaatctcccatcatt t" /listShort="S348" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1021619..1022137) /gene="yhaJ" /locus_tag="BSU_09965" /old_locus_tag="BSU09965" /function="16.5: Explore" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16845009, 21670523, 25651892; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane enzyme" /protein_id="NP_388878.2" /db_xref="EnsemblGenomes-Gn:BSU09965" /db_xref="EnsemblGenomes-Tr:CAB12837" /db_xref="GOA:O07518" /db_xref="InterPro:IPR021683" /db_xref="SubtiList:BG12986" /db_xref="UniProtKB/Swiss-Prot:O07518" /translation="MNCWKTINLMKDYGAVRIILTAVCFMILVFISTFLAFELLRPGT SLSDEYVSLFGGLLVVILFVHKVIHVLPIICKKRKIEKKFYILRMRTWKRIPKTTMLI SLVSPFLLITPVLFYAALAFPNHAHYFCMISGIHAGYCLPDFLLALKLIKAPKTAFID QEADGLDILVEK*" /label="yhaJ CDS" gene complement(1021619..1022137) /gene="yhaJ" /locus_tag="BSU_09965" /old_locus_tag="BSU09965" /label="yhaJ gene" promotor_-35 1021924..1021932 /Source="Nicolas_upshift_promotors" /id="U797" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=540 /SigmaFactorBS="ctatttttctttttttgcagatgattgGCAGGACATggatga ctttaTGTACAAATAAAATAACGAcgagcaaaccgccgaataaagatacatattcatc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1021944..1021962 /Source="Nicolas_upshift_promotors" /id="U797" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=540 /SigmaFactorBS="ctatttttctttttttgcagatgattgGCAGGACATggatga ctttaTGTACAAATAAAATAACGAcgagcaaaccgccgaataaagatacatattcatc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1021957 /Source="Nicolas_upshifts" /id="U797" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=540 /SigmaFactorBS="ctatttttctttttttgcagatgattgGCAGGACATggatga ctttaTGTACAAATAAAATAACGAcgagcaaaccgccgaataaagatacatattcatc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1022168..1022187) /Source="Nicolas_upshift_promotors" /id="U798" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.44955044955045" /psig="0.995004995004995" /xcortree=2615 /SigmaFactorBS="aaaaatacctgccggatgatattttttcttaaaaaagCATTG ATtttttctcttgggagGAGTAAATTATTTTGAGATTctattcaagatgtatggaagg a" /listShort="yhaJ, S350, S348" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1022186) /Source="Nicolas_upshifts" /id="U798" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.44955044955045" /psig="0.995004995004995" /xcortree=2615 /SigmaFactorBS="aaaaatacctgccggatgatattttttcttaaaaaagCATTG ATtttttctcttgggagGAGTAAATTATTTTGAGATTctattcaagatgtatggaagg a" /listShort="yhaJ, S350, S348" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1022203..1022209) /Source="Nicolas_upshift_promotors" /id="U798" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.44955044955045" /psig="0.995004995004995" /xcortree=2615 /SigmaFactorBS="aaaaatacctgccggatgatattttttcttaaaaaagCATTG ATtttttctcttgggagGAGTAAATTATTTTGAGATTctattcaagatgtatggaagg a" /listShort="yhaJ, S350, S348" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1022286..1022289 /Source="Nicolas_upshift_promotors" /id="U799" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.671328671328671" /psig="0.999000999001" /xcortree=2221 /SigmaFactorBS="gaaacaagcaaacaaactgcgaaatatggggttagaaCTTTc ttctcagtgaattATCAGCTAAAATAAGATTAAagatagaaagaagtggtgtggatgg a" /listShort="yhaI, S352" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1022304..1022323 /Source="Nicolas_upshift_promotors" /id="U799" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.671328671328671" /psig="0.999000999001" /xcortree=2221 /SigmaFactorBS="gaaacaagcaaacaaactgcgaaatatggggttagaaCTTTc ttctcagtgaattATCAGCTAAAATAAGATTAAagatagaaagaagtggtgtggatgg a" /listShort="yhaI, S352" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1022309 /Source="Nicolas_upshifts" /id="U799" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.671328671328671" /psig="0.999000999001" /xcortree=2221 /SigmaFactorBS="gaaacaagcaaacaaactgcgaaatatggggttagaaCTTTc ttctcagtgaattATCAGCTAAAATAAGATTAAagatagaaagaagtggtgtggatgg a" /listShort="yhaI, S352" /GFF_Attribute="listLong" /label="upshifts" CDS 1022345..1022686 /gene="yhaI" /locus_tag="BSU_09980" /old_locus_tag="BSU09980" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388879.1" /db_xref="EnsemblGenomes-Gn:BSU09980" /db_xref="EnsemblGenomes-Tr:CAB12838" /db_xref="InterPro:IPR015058" /db_xref="InterPro:IPR035945" /db_xref="PDB:1SED" /db_xref="SubtiList:BG12985" /db_xref="UniProtKB/Swiss-Prot:O07517" /translation="MDSMDHRIERLEYYIQLLVKTVDMDRYPFYALLIDKGLSKEEGE AVMRICDELSEELATQKAQGFVTFDKLLALFAGQLNEKLDVHETIFALYEQGLYQELM EVFIDIMKHFD*" /label="yhaI CDS" gene 1022345..1022686 /gene="yhaI" /locus_tag="BSU_09980" /old_locus_tag="BSU09980" /label="yhaI gene" S_feature complement(1022540..1022682) /Source="Nicolas_S_feature" /locus_tag="new_1072963_1073105_c" /HighExp="BC, S1, Sw, S2, S3, S8, S5, S4, S6, S7" /AntisenseName="yhaI" /AntisenseCor="5.4889858269512502E-2" /AntisenseRegPval="-0.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.989" /TUlongSig="NA" /TUlongPSig="NA" /label="S351" downshifts complement(1022583) /Source="Nicolas_upshifts" /id="D538" /incds=1 /nref=39 /ntot=209 /MaxReadThrough="2.89899" /MaxDrop="4.77791" /score="-6.0983333" /energy="-12.3" /TU="U801" /idTUdmin="U801" /TUdmin="-374" /isTUend="FALSE" /label="downshifts" CDS complement(1022683..1023294) /gene="scoC" /locus_tag="BSU_09990" /old_locus_tag="BSU09990" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14629015, 15126467, 16321961, 16923912, 19801406, 20382764, 23660663, 25966844, 26473603, 26728191, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14629015, 15126467, 16321961, 16923912, 19801406, 20382764, 23660663, 25966844, 26473603, 26728191, 22720735; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of extracellular protease production, sporulation and bacilysin production (MarR family)" /protein_id="NP_388880.1" /db_xref="EnsemblGenomes-Gn:BSU09990" /db_xref="EnsemblGenomes-Tr:CAB12839" /db_xref="GOA:P11065" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR023488" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2FXA" /db_xref="SubtiList:BG10659" /db_xref="UniProtKB/Swiss-Prot:P11065" /translation="MNRVEPPYDVKEALVFTQKMAQLSKALWKSIEKDWQQWLKPYDL NINEHHILWIAYQLNGASISEIAKFGVMHVSTAFNFSKKLEERGYLRFSKRLNDKRNT YVQLTEEGTEVFWSLLEEFDPTRNAVFKGSQPLYHLFGKFPEVAEMMCMIRHIYGDDF MEIFETSLTNIDNDFESVNGKLKKKAKDSAADEPAEELEPVNS*" /label="scoC CDS" gene complement(1022683..1023294) /gene="scoC" /locus_tag="BSU_09990" /old_locus_tag="BSU09990" /label="scoC gene" S_feature 1022687..1023452 /Source="Nicolas_S_feature" /locus_tag="new_1073110_1073875" /HighExp="Lbstat, Etha, T0.30H, Gly, M0t90, M40t90, M40t45, M0t45, H2O2, dia15" /AntisenseName="scoC" /AntisenseCor="-0.46322626361720198" /AntisenseRegPval="-15" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S352" downshifts complement(1022759) /Source="Nicolas_upshifts" /id="D539" /incds=1 /nref=1 /ntot=81 /MaxReadThrough="5.81117" /MaxDrop="2.1632" /score="-6.0983333" /energy="-12.3" /TU="U801" /idTUdmin="U801" /TUdmin="-550" /isTUend="FALSE" /label="downshifts" promotor_-35 1023290..1023294 /Source="Nicolas_upshift_promotors" /id="U800" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.632367632367632" /psig="0.177822177822178" /xcortree=3100 /SigmaFactorBS="agagcttctttcacatcatagggcggttccactcgaTTCATt acgtcaCCTGCTTCTCTTTTtctttttctctattatgccaataaaataaagattaata a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1023302..1023315 /Source="Nicolas_upshift_promotors" /id="U800" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.632367632367632" /psig="0.177822177822178" /xcortree=3100 /SigmaFactorBS="agagcttctttcacatcatagggcggttccactcgaTTCATt acgtcaCCTGCTTCTCTTTTtctttttctctattatgccaataaaataaagattaata a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1023314 /Source="Nicolas_upshifts" /id="U800" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.632367632367632" /psig="0.177822177822178" /xcortree=3100 /SigmaFactorBS="agagcttctttcacatcatagggcggttccactcgaTTCATt acgtcaCCTGCTTCTCTTTTtctttttctctattatgccaataaaataaagattaata a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1023319..1023338) /Source="Nicolas_upshift_promotors" /id="U801" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.656343656343656" /psig="0.98901098901099" /xcortree=2944 /SigmaFactorBS="cgtcgcaatggtttgtgaatttattaaaaaattcttacattt tcatCTTTattaatctttatttTATTGGCATAATAGAGAAAAagaaaaagagaagcag g" /listShort="scoC, S351" /listLong="yhaJ, S350, S348" /label="promotor_-10" upshifts complement(1023342) /Source="Nicolas_upshifts" /id="U801" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.656343656343656" /psig="0.98901098901099" /xcortree=2944 /SigmaFactorBS="cgtcgcaatggtttgtgaatttattaaaaaattcttacattt tcatCTTTattaatctttatttTATTGGCATAATAGAGAAAAagaaaaagagaagcag g" /listShort="scoC, S351" /listLong="yhaJ, S350, S348" /label="upshifts" promotor_-35 complement(1023353..1023356) /Source="Nicolas_upshift_promotors" /id="U801" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.656343656343656" /psig="0.98901098901099" /xcortree=2944 /SigmaFactorBS="cgtcgcaatggtttgtgaatttattaaaaaattcttacattt tcatCTTTattaatctttatttTATTGGCATAATAGAGAAAAagaaaaagagaagcag g" /listShort="scoC, S351" /listLong="yhaJ, S350, S348" /label="promotor_-35" downshifts 1023409 /Source="Nicolas_upshifts" /id="D540" /incds=0 /nref=1 /ntot=124 /MaxReadThrough="3.007" /MaxDrop="2.86547" /score="17.8486533" /energy="-7.1" /TU="U799,U800" /idTUdmin="U799" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(1023472..1023828) /gene="yhaH" /locus_tag="BSU_10000" /old_locus_tag="BSU10000" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11429463; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein; acid tolerance protein" /protein_id="NP_388881.1" /db_xref="EnsemblGenomes-Gn:BSU10000" /db_xref="EnsemblGenomes-Tr:CAB12840" /db_xref="GOA:O07516" /db_xref="InterPro:IPR024623" /db_xref="InterPro:IPR036191" /db_xref="SubtiList:BG12984" /db_xref="UniProtKB/Swiss-Prot:O07516" /translation="MASGRSLLTGLFVGGIIGGAAVLLTAPSSGKQLREKMKTNYDSF EETIKRLKSDGLALKDQLIKAAKESTDVIKDVGGELQTSIKKWQEEIKPHQQDLQKEI ADIEEKIRQLEKTLQN*" /label="yhaH CDS" gene complement(1023472..1023828) /gene="yhaH" /locus_tag="BSU_10000" /old_locus_tag="BSU10000" /label="yhaH gene" downshifts complement(1023476) /Source="Nicolas_upshifts" /id="D541" /incds=0 /nref=254 /ntot=287 /MaxReadThrough="1.65317" /MaxDrop="7.37381" /score="10.8990112" /energy="-7.9" /TU="NA" /idTUdmin="U804" /TUdmin=9 /isTUend="TRUE" /label="downshifts" promotor_-35 1023905..1023910 /Source="Nicolas_upshift_promotors" /id="U803" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1168 /SigmaFactorBS="ttcagcatttttcatttttgttgaaagcctgaacttctaTAC ATAgcttgctttattttaGCATATTTTTTAAGTGAAAaggagggagaaggttgtctgt c" /listShort="yhzF, S354" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(1023911..1023930) /Source="Nicolas_upshift_promotors" /id="U802" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=1914 /SigmaFactorBS="aggataatacaatcaaaaagacagacaaccttctccctcctt ttcacttaaaaaaTATGCTAAAATAAAGCAAGCtatgtatagaagttcaggctttcaa c" /listShort="yhaH" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1023925) /Source="Nicolas_upshifts" /id="U802" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=1914 /SigmaFactorBS="aggataatacaatcaaaaagacagacaaccttctccctcctt ttcacttaaaaaaTATGCTAAAATAAAGCAAGCtatgtatagaagttcaggctttcaa c" /listShort="yhaH" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1023926..1023944 /Source="Nicolas_upshift_promotors" /id="U803" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1168 /SigmaFactorBS="ttcagcatttttcatttttgttgaaagcctgaacttctaTAC ATAgcttgctttattttaGCATATTTTTTAAGTGAAAaggagggagaaggttgtctgt c" /listShort="yhzF, S354" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1023926 /Source="Nicolas_upshifts" /id="U803" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1168 /SigmaFactorBS="ttcagcatttttcatttttgttgaaagcctgaacttctaTAC ATAgcttgctttattttaGCATATTTTTTAAGTGAAAaggagggagaaggttgtctgt c" /listShort="yhzF, S354" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1023927..1024190) /Source="Nicolas_S_feature" /locus_tag="new_1074350_1074613_c" /HighExp="Etha, Salt, HiTm, Heat, Diami, Sw, Gly, S1, MG 10, MG 60" /AntisenseName="yhzF" /AntisenseCor="-0.69425315975357205" /AntisenseRegPval="-39.299999999999997" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.969, 0.962, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S353" CDS 1023958..1024149 /gene="yhzF" /locus_tag="BSU_10009" /old_locus_tag="BSU10009" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="membrane protein of unknown function" /protein_id="YP_003097700.1" /db_xref="EnsemblGenomes-Gn:BSU10009" /db_xref="EnsemblGenomes-Tr:CAX52588" /db_xref="GOA:C0H3Y3" /db_xref="UniProtKB/Swiss-Prot:C0H3Y3" /translation="MSVFLIVLSCITLAFASGAVYYIKLLSQAASYPPKRVIRQKALV CSTGTAFTLCLIFFTKLLA*" /label="yhzF CDS" gene 1023958..1024149 /gene="yhzF" /locus_tag="BSU_10009" /old_locus_tag="BSU10009" /label="yhzF gene" S_feature 1024150..1025585 /Source="Nicolas_S_feature" /locus_tag="new_1074573_1076008" /HighExp="S3, S8, S4, S6, S7, T5.0H, C30, S5, T4.0H, T3.30H" /AntisenseName="trpP" /AntisenseCor="-0.20038256384636899" /AntisenseRegPval="-3" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S354" CDS complement(1024223..1024741) /gene="trpP" /locus_tag="BSU_10010" /old_locus_tag="BSU10010" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10735881, 14702295, 15849754, 16850406, 16879415, 17114263" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10735881, 14702295, 15849754, 16850406, 16879415, 17114263; Product type t : transporter" /codon_start=1 /transl_table=11 /product="tryptophan transporter or sensor" /protein_id="NP_388882.2" /db_xref="EnsemblGenomes-Gn:BSU10010" /db_xref="EnsemblGenomes-Tr:CAB12841" /db_xref="GOA:O07515" /db_xref="InterPro:IPR031360" /db_xref="SubtiList:BG12983" /db_xref="UniProtKB/Swiss-Prot:O07515" /translation="MKTKELVIMALFAAIGAALHSIIPPFLGGMKPDMMLIMMFMGIL LFPRVQNVLVIGIVTGIISALTTAFPAGQIPNIIDKPVSAFLFFSLFLLFRKSRKTGA AAVLTVIGTILSGIVFLSSALLIVGLPGGFAALFAAVVLPAAVLNTISMIIIYPIVQT ILRRSSFMEAAK*" /label="trpP CDS" gene complement(1024223..1024741) /gene="trpP" /locus_tag="BSU_10010" /old_locus_tag="BSU10010" /label="trpP gene" downshifts complement(1024235) /Source="Nicolas_upshifts" /id="D542" /incds=0 /nref=105 /ntot=253 /MaxReadThrough="6.00956" /MaxDrop="4.62812" /score="24.5949542" /energy="-12.8" /TU="U804,U805,U806" /idTUdmin="U804" /TUdmin="-750" /isTUend="FALSE" /label="downshifts" S_feature complement(1024742..1024829) /Source="Nicolas_S_feature" /locus_tag="new_1075165_1075252_c" /HighExp="C90, B60, S1, GM 15, MG 45, MG-0.2, Etha, Lbtran, MG 25, MG t5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.969, 0.962, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S355" promotor_-10 complement(1024821..1024840) /Source="Nicolas_upshift_promotors" /id="U804" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.541458541458541" /psig="0.969030969030969" /xcortree=591 /SigmaFactorBS="aaattccagcaggaaaatgagtaaaaagTCTGGCTAtgcaaa ccgtccgTTTGGTATACTGTTTGCATAacacattctgtaaagccttcgcaataaatga t" /listShort="S355, trpP, S353, yhaH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1024829) /Source="Nicolas_upshifts" /id="U804" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.541458541458541" /psig="0.969030969030969" /xcortree=591 /SigmaFactorBS="aaattccagcaggaaaatgagtaaaaagTCTGGCTAtgcaaa ccgtccgTTTGGTATACTGTTTGCATAacacattctgtaaagccttcgcaataaatga t" /listShort="S355, trpP, S353, yhaH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1024854..1024861) /Source="Nicolas_upshift_promotors" /id="U804" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.541458541458541" /psig="0.969030969030969" /xcortree=591 /SigmaFactorBS="aaattccagcaggaaaatgagtaaaaagTCTGGCTAtgcaaa ccgtccgTTTGGTATACTGTTTGCATAacacattctgtaaagccttcgcaataaatga t" /listShort="S355, trpP, S353, yhaH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1024866..1025945) /gene="serC" /locus_tag="BSU_10020" /old_locus_tag="BSU10020" /EC_number="2.6.1.52" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:4337849, 16233211" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4337849, 16233211; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoserine aminotransferase" /protein_id="NP_388883.1" /db_xref="EnsemblGenomes-Gn:BSU10020" /db_xref="EnsemblGenomes-Tr:CAB12842" /db_xref="GOA:P80862" /db_xref="InterPro:IPR000192" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR020578" /db_xref="InterPro:IPR022278" /db_xref="SubtiList:BG12673" /db_xref="UniProtKB/Swiss-Prot:P80862" /translation="MERTTNFNAGPAALPLEVLQKAQKEFIDFNESGMSVMELSHRSK EYEAVHQKAKSLLIELMGIPEDYDILFLQGGASLQFSMLPMNFLTPEKTAHFVMTGAW SEKALAETKLFGNTSITATSETDNYSYIPEVDLTDVKDGAYLHITSNNTIFGTQWQEF PNSPIPLVADMSSDILSRKIDVSKFDVIYGGAQKNLGPSGVTVVIMKKSWLQNENANV PKILKYSTHVKADSLYNTPPTFAIYMLSLVLEWLKENGGVEAVEQRNEQKAQVLYSCI DESNGFYKGHARKDSRSRMNVTFTLRDDELTKTFVQKAKDAKMIGLGGHRSVGGCRAS IYNAVSLEDCEKLAAFMKKFQQENE*" /label="serC CDS" gene complement(1024866..1025945) /gene="serC" /locus_tag="BSU_10020" /old_locus_tag="BSU10020" /label="serC gene" misc_feature complement(1025984..1026003) /Source="Nicolas_upshift_promotors" /id="U805" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.772227772227772" /psig="0.962037962037962" /xcortree=3059 /SigmaFactorBS="atccgtcaatttcttttgataattctaattttttatcaaaaa actgaattttTGTGATAGGATAATTGTATTattttatacattaacgtggaaaacaggg a" /listShort="serC, S355, trpP, S353, yhaH" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1025995) /Source="Nicolas_upshifts" /id="U805" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.772227772227772" /psig="0.962037962037962" /xcortree=3059 /SigmaFactorBS="atccgtcaatttcttttgataattctaattttttatcaaaaa actgaattttTGTGATAGGATAATTGTATTattttatacattaacgtggaaaacaggg a" /listShort="serC, S355, trpP, S353, yhaH" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1025997..1026078) /Source="Nicolas_S_feature" /locus_tag="new_1076420_1076501_c" /HighExp="Etha, dia15, H2O2, LBGtran, G135, G180, dia5, G150, Lbexp, M0t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S356" CDS complement(1026092..1026529) /gene="hinT" /locus_tag="BSU_10030" /old_locus_tag="BSU10030" /EC_number="3.6.1.29" /EC_number="3.6.1.-" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9579061, 15703176, 16934294, 17217311, 26181368, 28516732; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="promiscuous Hit-family phosphohydrolase, adenosine phosphoramidase" /protein_id="NP_388884.1" /db_xref="EnsemblGenomes-Gn:BSU10030" /db_xref="EnsemblGenomes-Tr:CAB12843" /db_xref="GOA:O07513" /db_xref="InterPro:IPR001310" /db_xref="InterPro:IPR011146" /db_xref="InterPro:IPR019808" /db_xref="InterPro:IPR036265" /db_xref="PDB:1Y23" /db_xref="SubtiList:BG12607" /db_xref="UniProtKB/Swiss-Prot:O07513" /translation="MHCAENCIFCKIIAGDIPSAKVYEDEHVLAFLDISQVTKGHTLV IPKTHIENVYEFTDELAKQYFHAVPKIARAIRDEFEPIGLNTLNNNGEKAGQSVFHYH MHIIPRYGKGDGFGAVWKTHADDYKPEDLQNISSSIAKRLASS*" /label="hinT CDS" gene complement(1026092..1026529) /gene="hinT" /locus_tag="BSU_10030" /old_locus_tag="BSU10030" /label="hinT gene" downshifts complement(1026123) /Source="Nicolas_upshifts" /id="D543" /incds=0 /nref=187 /ntot=248 /MaxReadThrough="4.31506" /MaxDrop="5.61862" /score="-0.366845751" /energy="-8.6" /TU="U806" /idTUdmin="U807" /TUdmin=4 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1026562..1026581) /Source="Nicolas_upshift_promotors" /id="U806" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2360 /SigmaFactorBS="tctgcattcagggtgaacgctcgccgttcatcctGTTTTCTA ttttctgcatttcTGTGGTACGATGAATGTATAcatactaaacaatttcataaggagg a" /listShort="hinT, S356, serC, S355, trpP, S353, yhaH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1026576) /Source="Nicolas_upshifts" /id="U806" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2360 /SigmaFactorBS="tctgcattcagggtgaacgctcgccgttcatcctGTTTTCTA ttttctgcatttcTGTGGTACGATGAATGTATAcatactaaacaatttcataaggagg a" /listShort="hinT, S356, serC, S355, trpP, S353, yhaH" /GFF_Attribute="listLong" /label="upshifts" downshifts 1026579 /Source="Nicolas_upshifts" /id="D544" /incds=0 /nref=1 /ntot=3 /MaxReadThrough="2.3752" /MaxDrop="3.02008" /score="-3.56654132" /energy="-13.3" /TU="NA" /idTUdmin="U803" /TUdmin=1034 /isTUend="FALSE" /label="downshifts" promotor_-35 complement(1026595..1026602) /Source="Nicolas_upshift_promotors" /id="U806" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2360 /SigmaFactorBS="tctgcattcagggtgaacgctcgccgttcatcctGTTTTCTA ttttctgcatttcTGTGGTACGATGAATGTATAcatactaaacaatttcataaggagg a" /listShort="hinT, S356, serC, S355, trpP, S353, yhaH" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(1026601..1026897) /Source="Nicolas_S_feature" /locus_tag="new_1077024_1077320_c" /HighExp="S7, S8, S6, S5, BT, ferm, nit, G/S, S4, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S357" downshifts complement(1026644) /Source="Nicolas_upshifts" /id="D545" /incds=0 /nref=40 /ntot=72 /MaxReadThrough="3.07347" /MaxDrop="7.69075" /score="9.88617558" /energy="-14.2" /TU="U807" /idTUdmin="U807" /TUdmin="-517" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1026895..1026906) /Source="Nicolas_upshift_promotors" /id="U807" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=832 /SigmaFactorBS="aaacaattcccttttaacaaatgatgaatttgctGTCATAAa gagacagggttctGGACATCATAAAagttgtagaggaaaagcatatcaactgaaaaat g" /listShort="S357, hinT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1026901) /Source="Nicolas_upshifts" /id="U807" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=832 /SigmaFactorBS="aaacaattcccttttaacaaatgatgaatttgctGTCATAAa gagacagggttctGGACATCATAAAagttgtagaggaaaagcatatcaactgaaaaat g" /listShort="S357, hinT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1026921..1026927) /Source="Nicolas_upshift_promotors" /id="U807" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=832 /SigmaFactorBS="aaacaattcccttttaacaaatgatgaatttgctGTCATAAa gagacagggttctGGACATCATAAAagttgtagaggaaaagcatatcaactgaaaaat g" /listShort="S357, hinT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1026957..1026964 /Source="Nicolas_upshift_promotors" /id="U808" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.553446553446553" /psig=1 /xcortree=1921 /SigmaFactorBS="cagcaaattcatcatttgttaaaagggaatTGTTTCAAatca ggccttgttTTTGGTACTATGAAGAAAAAcactataaggggagaaactatgtctctgc t" /listShort="ecsA, ecsB, ecsC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1026978..1026997 /Source="Nicolas_upshift_promotors" /id="U808" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.553446553446553" /psig=1 /xcortree=1921 /SigmaFactorBS="cagcaaattcatcatttgttaaaagggaatTGTTTCAAatca ggccttgttTTTGGTACTATGAAGAAAAAcactataaggggagaaactatgtctctgc t" /listShort="ecsA, ecsB, ecsC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1026987 /Source="Nicolas_upshifts" /id="U808" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.553446553446553" /psig=1 /xcortree=1921 /SigmaFactorBS="cagcaaattcatcatttgttaaaagggaatTGTTTCAAatca ggccttgttTTTGGTACTATGAAGAAAAAcactataaggggagaaactatgtctctgc t" /listShort="ecsA, ecsB, ecsC" /GFF_Attribute="listLong" /label="upshifts" CDS 1027017..1027760 /gene="ecsA" /locus_tag="BSU_10040" /old_locus_tag="BSU10040" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8581172, 10027970, 11807061, 18599827, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8581172, 10027970, 11807061, 18599827, 26735940; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (ATP-binding protein)" /protein_id="NP_388885.1" /db_xref="EnsemblGenomes-Gn:BSU10040" /db_xref="EnsemblGenomes-Tr:CAB12844" /db_xref="GOA:P55339" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11516" /db_xref="UniProtKB/Swiss-Prot:P55339" /translation="MSLLSVKDLTGGYTRNPVLKNVSFTLEPNQIVGLIGLNGAGKST TIRHIIGLMDPHKGSIELNGKTFAEDPEGYRSQFTYIPETPVLYEELTLMEHLELTAM AYGLSKETMEKRLPPLLKEFRMEKRLKWFPAHFSKGMKQKVMIMCAFLAEPALYIIDE PFLGLDPLAINALLERMNEAKKGGASVLMSTHILATAERYCDSFIILHNGEVRARGTL SELREQFGMKDAALDDLYLELTKEDAGHE*" /label="ecsA CDS" gene 1027017..1027760 /gene="ecsA" /locus_tag="BSU_10040" /old_locus_tag="BSU10040" /label="ecsA gene" CDS 1027753..1028979 /gene="ecsB" /locus_tag="BSU_10050" /old_locus_tag="BSU10050" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8581172, 10027970, 15175311, 15849754, 16850406, 18599827, 21665535, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8581172, 10027970, 15175311, 15849754, 16850406, 18599827, 21665535, 26735940; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (permease subunit)" /protein_id="NP_388886.1" /db_xref="EnsemblGenomes-Gn:BSU10050" /db_xref="EnsemblGenomes-Tr:CAB12845" /db_xref="GOA:P55340" /db_xref="InterPro:IPR010288" /db_xref="SubtiList:BG11517" /db_xref="UniProtKB/Swiss-Prot:P55340" /translation="MNNMLDIWQSRLQEHIKETRTYMKYMLNDHLVIVLIFFLAGAAS WYSKWIRDIPAHFPSFWVMAVLFSLVLTSSYVRTLLKEADLVFLLPLEAKMEPYLKQA FVYSYVSQLFPLIALSIVAMPLYFAVTPGASLVSYAAVFVQLLLLKAWNQVMEWRTTF QNDRSMKRMDVIIRFAANTLVLYFVFQSVYMYALLVYVIMAVLYLYMSSAAKRKTFKW ESHIESELRRKQRFYRIANLFTDVPHLRKQAKRRAYLDFLLRLVPFEQRKTFAYMFTR AFLRSSDYLGILVRLTIVFALIIMYVSASPLIAAVLTVFAIFITGIQLLPLFGHFDHL ALQELYPVQKETKLKSYFSLLKTALSIQALLMSVASAYAAGLTGFLYALIGSAVLIFV VLPAYMTTRLKKHGKL*" /label="ecsB CDS" gene 1027753..1028979 /gene="ecsB" /locus_tag="BSU_10050" /old_locus_tag="BSU10050" /label="ecsB gene" promotor_-10 complement(1028312..1028330) /Source="Nicolas_upshift_promotors" /id="U809" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1033 /SigmaFactorBS="tttgctgcggaagacatatacagataaagaacagccATAATG acatagacgagaagcGCATACATATAAACAGATTggaaaacaaaataaagaacgagtg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1028327) /Source="Nicolas_upshifts" /id="U809" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1033 /SigmaFactorBS="tttgctgcggaagacatatacagataaagaacagccATAATG acatagacgagaagcGCATACATATAAACAGATTggaaaacaaaataaagaacgagtg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1028346..1028351) /Source="Nicolas_upshift_promotors" /id="U809" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1033 /SigmaFactorBS="tttgctgcggaagacatatacagataaagaacagccATAATG acatagacgagaagcGCATACATATAAACAGATTggaaaacaaaataaagaacgagtg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1028999..1029709 /gene="ecsC" /locus_tag="BSU_10060" /old_locus_tag="BSU10060" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8581172, 10027970; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_388887.1" /db_xref="EnsemblGenomes-Gn:BSU10060" /db_xref="EnsemblGenomes-Tr:CAB12846" /db_xref="InterPro:IPR024787" /db_xref="SubtiList:BG11518" /db_xref="UniProtKB/Swiss-Prot:P55341" /translation="MTDNQLLMQEALEWKMHFLRKDSMFERFSKRVQTKVNERIPEKI HTVVTESVKKMVEATMAGSNIITYKKDTSALSLSEKNELAKKTIVSYQKVAAAEGVGT GAGGIFLSIADFPLLLSIKMKCLFTLSSIYGFDVKDAQERIFLLLVFQLAFSSDDGRK SLFSVIENWETEKKSIDWRVFQQEYRDYIDVVKLFQLLPGVGAAVGGIANYKLLAQLG ETARHVFHLRILKETAGE*" /label="ecsC CDS" gene 1028999..1029709 /gene="ecsC" /locus_tag="BSU_10060" /old_locus_tag="BSU10060" /label="ecsC gene" downshifts 1029673 /Source="Nicolas_upshifts" /id="D546" /incds=0 /nref=78 /ntot=231 /MaxReadThrough="1.36097" /MaxDrop="4.78417" /score="28.5337351" /energy="-14.6" /TU="NA" /idTUdmin="U808" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" CDS complement(1029727..1030917) /gene="sndC" /locus_tag="BSU_10070" /old_locus_tag="BSU10070" /EC_number="3.5.1.-" /experiment="publication(s) with functional evidences, PMID:23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetyl amino acid acetylase, promiscuous activity" /protein_id="NP_388888.2" /db_xref="EnsemblGenomes-Gn:BSU10070" /db_xref="EnsemblGenomes-Tr:CAB12847" /db_xref="GOA:O07598" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR017439" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG12982" /db_xref="UniProtKB/Swiss-Prot:O07598" /translation="MSISTLQKEINKQLDGCFEEMVEIRRHFHMYPELSFQEEKTAAF IASYYESLGVPIRTNVGGRGVLANIEGSEPGPTVALRADFDALPIQDEKDVPYASKVP GVMHACGHDGHTAALLAVAKVLHQNRHELKGTFVMIHQHAEEYYPGGAKPMIDDGCLE NTDVIFGTHLWATEPLGTILCRPGAVMAAADRFTIKVFGKGGHGAHPHDTKDAVLIGS QIVSSLQHIVSRKVNPIQSAVISTGSFIADNPFNVIADQAVLIGTARSFDENVRDILE KEIEAVVKGICSMHGASYEYTYEQGYPAVVNHPAETNHLVSTAKNTEGVQQVIDGEPQ MGGEDFAYYLQNVKGTFFFTGAAPEQPERVYSHHHPKFDINEKAMLTAAKVLAGAAIT YHQL*" /label="sndC CDS" gene complement(1029727..1030917) /gene="sndC" /locus_tag="BSU_10070" /old_locus_tag="BSU10070" /label="sndC gene" downshifts complement(1029737) /Source="Nicolas_upshifts" /id="D547" /incds=0 /nref=11 /ntot=162 /MaxReadThrough="3.12546" /MaxDrop="4.15559" /score="-4.78420642" /energy="-14.6" /TU="U810" /idTUdmin="U811" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" downshifts complement(1029802) /Source="Nicolas_upshifts" /id="D548" /incds=1 /nref=25 /ntot=206 /MaxReadThrough="4.92378" /MaxDrop="3.21645" /score="-4.78420642" /energy="-14.6" /TU="U810,U811" /idTUdmin="U811" /TUdmin="-67" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1030941..1030960) /Source="Nicolas_upshift_promotors" /id="U810" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.498501498501498" /psig=1 /xcortree=2900 /SigmaFactorBS="gtgacaaccctcgcagctgtgatgatgctttaaaacagcatg aGTTGAAatattcagactttTTCTATACAATCATGGAAAAgcatagaaaagggggaag c" /listShort="yhaA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1030962) /Source="Nicolas_upshifts" /id="U810" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.498501498501498" /psig=1 /xcortree=2900 /SigmaFactorBS="gtgacaaccctcgcagctgtgatgatgctttaaaacagcatg aGTTGAAatattcagactttTTCTATACAATCATGGAAAAgcatagaaaagggggaag c" /listShort="yhaA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1030974..1030979) /Source="Nicolas_upshift_promotors" /id="U810" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.498501498501498" /psig=1 /xcortree=2900 /SigmaFactorBS="gtgacaaccctcgcagctgtgatgatgctttaaaacagcatg aGTTGAAatattcagactttTTCTATACAATCATGGAAAAgcatagaaaagggggaag c" /listShort="yhaA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1030990..1032381) /gene="yhfA" /locus_tag="BSU_10080" /old_locus_tag="BSU10080" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 12107147; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_388889.1" /db_xref="EnsemblGenomes-Gn:BSU10080" /db_xref="EnsemblGenomes-Tr:CAB12848" /db_xref="GOA:O07599" /db_xref="SubtiList:BG13047" /db_xref="UniProtKB/Swiss-Prot:O07599" /translation="MMEVGILPVHVLYVFFIGAIILFMLLRKDTTFISLFGIFIISLW ASHSLSASVSSLFHSFIYAAGELLPTIFIICFIVSMSDLLTKTGINEAMISPFASLVR GPVTAYWLIGGLMFAISLFFWPSPGVALIGAVLLPAAARAGLTPLAAAMAMNLFGHGF ALSGDFVIQAAPKLTADAAGIPVGDVVSASIPLVLIMGVTTTTAAFIMIQRERKKQEH PTSFSPVLSGEQDNSLYLPKRLRSILAFLIPLAFLADIACMLLFNLQGNDATALIGGS AICILFTVHFFVYKHKGLEKITGYFIDGFKFGFKVFGPVIPIAAFFYLGDSGYESILG TSLPKGSHGIVNDLGIALSHMMPMSKELAATALTAAGAITGLDGSGFSGISLAGSIAK LFSSALHADPAILTALGQISAIWVGGGTLVPWALIPAAAICKVDPFELARKNFIPVAI GLLVTTLAAVMML*" /label="yhfA CDS" gene complement(1030990..1032381) /gene="yhfA" /locus_tag="BSU_10080" /old_locus_tag="BSU10080" /label="yhfA gene" promotor_-10 complement(1032392..1032411) /Source="Nicolas_upshift_promotors" /id="U811" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1283 /SigmaFactorBS="ttccatcataaccctcccctctgtCCCGGCACCTtccgcccg cctaTGAATAATCTGTAAGCGGAAggagtgatcgatgatggaagtcgggattttgcct g" /listShort="yhfA, yhaA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1032397) /Source="Nicolas_upshifts" /id="U811" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1283 /SigmaFactorBS="ttccatcataaccctcccctctgtCCCGGCACCTtccgcccg cctaTGAATAATCTGTAAGCGGAAggagtgatcgatgatggaagtcgggattttgcct g" /listShort="yhfA, yhaA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1032424..1032433) /Source="Nicolas_upshift_promotors" /id="U811" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1283 /SigmaFactorBS="ttccatcataaccctcccctctgtCCCGGCACCTtccgcccg cctaTGAATAATCTGTAAGCGGAAggagtgatcgatgatggaagtcgggattttgcct g" /listShort="yhfA, yhaA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1032447..1032761) /gene="yhgB" /locus_tag="BSU_10090" /old_locus_tag="BSU10090" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_388890.1" /db_xref="EnsemblGenomes-Gn:BSU10090" /db_xref="EnsemblGenomes-Tr:CAB12849" /db_xref="SubtiList:BG10426" /db_xref="UniProtKB/Swiss-Prot:P38048" /translation="MKHTCPVCGFKDWLNRHMIMKAIILMKSARAAVFSSDLMSTRCS TRITHIEPSESIIAYRKNWLAEGCVIFSPECFPKHLQKANRGLRHHLIEQLKQINVHL PS*" /label="yhgB CDS" gene complement(1032447..1032761) /gene="yhgB" /locus_tag="BSU_10090" /old_locus_tag="BSU10090" /label="yhgB gene" CDS complement(1032806..1033306) /gene="hmoB" /locus_tag="BSU_10100" /old_locus_tag="BSU10100" /EC_number="1.14.99.48" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:21873409, 22531134, 24582752" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21873409, 22531134, 24582752; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="heme-degrading monooxygenase" /protein_id="NP_388891.1" /db_xref="EnsemblGenomes-Gn:BSU10100" /db_xref="EnsemblGenomes-Tr:CAB12850" /db_xref="GOA:P38049" /db_xref="InterPro:IPR007138" /db_xref="InterPro:IPR011008" /db_xref="PDB:4OZ5" /db_xref="SubtiList:BG10427" /db_xref="UniProtKB/Swiss-Prot:P38049" /translation="MKVYITYGTADFLKTIVQKHPSENILLMQGQENAILIHETNGDT VFQAPHAYEVIDQVGEIKHPGFAVLNNIAVTQEGRPLFENRFKNRAGKVENEPGFEAI RVLRPLDSDTYVILTLWETESAFQDWQQSGSYKEAHKKRDTSAGIDTTSIFSRPSYVT TYFAVE*" /label="hmoB CDS" gene complement(1032806..1033306) /gene="hmoB" /locus_tag="BSU_10100" /old_locus_tag="BSU10100" /label="hmoB gene" downshifts complement(1032833) /Source="Nicolas_upshifts" /id="D549" /incds=0 /nref=145 /ntot=254 /MaxReadThrough="3.45185" /MaxDrop="5.6374" /score="15.5142908" /energy="-14.8" /TU="U812" /idTUdmin="U812" /TUdmin="-546" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1033319..1033338) /Source="Nicolas_upshift_promotors" /id="U812" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.555444555444555" /psig="0.98101898101898" /xcortree=101 /SigmaFactorBS="tatgggaaaaattgtttggaattatgttcgaagcactcgcca atAGaaacttataccattgtTTTGATATACTAGCAAGCAGgaggtggctgatatgaag g" /listShort="yhgC, yhgB, yhfA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 1033321..1033325 /Source="Nicolas_upshift_promotors" /id="U813" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.953046953046953" /psig="0.957042957042957" /xcortree=1837 /SigmaFactorBS="tcccatatgtaatataaaccttcatatcagccacctcctGCT TGctagtatatcaaaacAATGGTATAAGTTTCTATTGgcgagtgcttcgaacataatt c" /listShort="pbpF, hemE, hemH, hemY" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(1033340) /Source="Nicolas_upshifts" /id="U812" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.555444555444555" /psig="0.98101898101898" /xcortree=101 /SigmaFactorBS="tatgggaaaaattgtttggaattatgttcgaagcactcgcca atAGaaacttataccattgtTTTGATATACTAGCAAGCAGgaggtggctgatatgaag g" /listShort="yhgC, yhgB, yhfA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1033341..1033360 /Source="Nicolas_upshift_promotors" /id="U813" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.953046953046953" /psig="0.957042957042957" /xcortree=1837 /SigmaFactorBS="tcccatatgtaatataaaccttcatatcagccacctcctGCT TGctagtatatcaaaacAATGGTATAAGTTTCTATTGgcgagtgcttcgaacataatt c" /listShort="pbpF, hemE, hemH, hemY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1033342 /Source="Nicolas_upshifts" /id="U813" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.953046953046953" /psig="0.957042957042957" /xcortree=1837 /SigmaFactorBS="tcccatatgtaatataaaccttcatatcagccacctcctGCT TGctagtatatcaaaacAATGGTATAAGTTTCTATTGgcgagtgcttcgaacataatt c" /listShort="pbpF, hemE, hemH, hemY" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1033355..1033356) /Source="Nicolas_upshift_promotors" /id="U812" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.555444555444555" /psig="0.98101898101898" /xcortree=101 /SigmaFactorBS="tatgggaaaaattgtttggaattatgttcgaagcactcgcca atAGaaacttataccattgtTTTGATATACTAGCAAGCAGgaggtggctgatatgaag g" /listShort="yhgC, yhgB, yhfA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1033373..1033379 /Source="Nicolas_upshift_promotors" /id="U814" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=871 /SigmaFactorBS="acaatggtataagtttctattggcgagtgcttcgAACATAAt tccaaacaattttTCCCATACTACCtttagaaaggcgaggtgagttcatgtttaagat a" /listShort="pbpF, hemE, hemH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1033394..1033405 /Source="Nicolas_upshift_promotors" /id="U814" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=871 /SigmaFactorBS="acaatggtataagtttctattggcgagtgcttcgAACATAAt tccaaacaattttTCCCATACTACCtttagaaaggcgaggtgagttcatgtttaagat a" /listShort="pbpF, hemE, hemH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1033399 /Source="Nicolas_upshifts" /id="U814" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=871 /SigmaFactorBS="acaatggtataagtttctattggcgagtgcttcgAACATAAt tccaaacaattttTCCCATACTACCtttagaaaggcgaggtgagttcatgtttaagat a" /listShort="pbpF, hemE, hemH" /GFF_Attribute="listLong" /label="upshifts" CDS 1033428..1035572 /gene="pbpF" /locus_tag="BSU_10110" /old_locus_tag="BSU10110" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8335642, 11567005, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8335642, 11567005, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="penicillin-binding protein 2C (1F class) required for spore germination" /protein_id="NP_388892.2" /db_xref="EnsemblGenomes-Gn:BSU10110" /db_xref="EnsemblGenomes-Tr:CAB12851" /db_xref="GOA:P38050" /db_xref="InterPro:IPR001264" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR023346" /db_xref="InterPro:IPR036950" /db_xref="SubtiList:BG10428" /db_xref="UniProtKB/Swiss-Prot:P38050" /translation="MFKIKKKKLFIPIIILVLTAFLALIGYISIIFLGHYVIDEKKLI LHASSKIVDQNGDEVASLYTENREPVSINEIPKQVREAFIAVEDKRFYEHHGIDAKSV GRAVYRDILAGGKVEGGSTITQQLAKNIFLTHDKTFLRKTKEVIIAINLERDYSKDKL LEMYLNQLYFGHGVYGIQAASHYYFNKEVKDLTVSEGAVLAAIPKAPSTYSPILHPDK NKERRDTILGMMNDQGYISAKEAVTAQGRTLGLHVKKQSETPWFDSYIDLVIKEAEDK YSISGEQLLQGGYTIKVPLDSKLQKTAYQVMKEGSYYPGTDQNAEGSAVFINNKTGGV EAAIGGRDYTSKGYNRVTAVRQPGSTFKPLAVYGPAMQEKKFKPYSLLKDELQSYGDY TPKNYDSRYEGEVTMSDAITYSKNAPAVWTLNEIGVETGKSYLKANGIDIPDEGLALA LGGLEKGVSPLQLAGAFHTFAANGTYTEPFFISSIIDEDGETIADHKEEGKRVFSKQT SWNMTRMLQQVVKKGTATSGTYHGDLAGKTGSTSYTGVSGATKDAWFAGYTPKITGAV WMGYDKTDQNHYLKAGSSYPTRLFKDILTQAGETGHVFTKPKNVKELESPIELKPVKT LTADYTFKAAGLFTIELKWDAQEDDRAVYRIYVNKDGEETLLDSVEGKGSYEIPYANL FSGASYKIVPYNTQTKREGEGTDYVQPKLFSS*" /label="pbpF CDS" gene 1033428..1035572 /gene="pbpF" /locus_tag="BSU_10110" /old_locus_tag="BSU10110" /label="pbpF gene" promotor_-10 complement(1033472..1033483) /Source="Nicolas_upshift_promotors" /id="U815" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.595404595404595" /psig="0.595404595404595" /xcortree=1190 /SigmaFactorBS="ataatggccgagaaaaataattgaaatatatcCTATTAAagc gagaaaagcaGTTAACACTAAAataatgataggtataaaaagtttctttttctttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1033475) /Source="Nicolas_upshifts" /id="U815" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.595404595404595" /psig="0.595404595404595" /xcortree=1190 /SigmaFactorBS="ataatggccgagaaaaataattgaaatatatcCTATTAAagc gagaaaagcaGTTAACACTAAAataatgataggtataaaaagtttctttttctttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1033497..1033503) /Source="Nicolas_upshift_promotors" /id="U815" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.595404595404595" /psig="0.595404595404595" /xcortree=1190 /SigmaFactorBS="ataatggccgagaaaaataattgaaatatatcCTATTAAagc gagaaaagcaGTTAACACTAAAataatgataggtataaaaagtttctttttctttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1035609..1035615 /Source="Nicolas_upshift_promotors" /id="U816" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.377622377622378" /psig="0.998001998001998" /xcortree=1606 /SigmaFactorBS="tcggcgattttttgaactttgagctacattTCTATACcattt gcctaaaaCAAGGTATAGTGTAATAAGTcaagaaatacgaacgtatggttgccgtatg a" /listShort="hemE, hemH, hemY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1035629..1035648 /Source="Nicolas_upshift_promotors" /id="U816" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.377622377622378" /psig="0.998001998001998" /xcortree=1606 /SigmaFactorBS="tcggcgattttttgaactttgagctacattTCTATACcattt gcctaaaaCAAGGTATAGTGTAATAAGTcaagaaatacgaacgtatggttgccgtatg a" /listShort="hemE, hemH, hemY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1035639 /Source="Nicolas_upshifts" /id="U816" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.377622377622378" /psig="0.998001998001998" /xcortree=1606 /SigmaFactorBS="tcggcgattttttgaactttgagctacattTCTATACcattt gcctaaaaCAAGGTATAGTGTAATAAGTcaagaaatacgaacgtatggttgccgtatg a" /listShort="hemE, hemH, hemY" /GFF_Attribute="listLong" /label="upshifts" CDS 1035694..1036755 /gene="hemE" /locus_tag="BSU_10120" /old_locus_tag="BSU10120" /EC_number="4.1.1.37" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10217486, 17122346" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10217486, 17122346; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="uroporphyrinogen III decarboxylase" /protein_id="NP_388893.1" /db_xref="EnsemblGenomes-Gn:BSU10120" /db_xref="EnsemblGenomes-Tr:CAB12852" /db_xref="GOA:P32395" /db_xref="InterPro:IPR000257" /db_xref="InterPro:IPR006361" /db_xref="PDB:2INF" /db_xref="SubtiList:BG10429" /db_xref="UniProtKB/Swiss-Prot:P32395" /translation="MSKRETFNETFLKAARGEKADHTPVWYMRQAGRSQPEYRKLKEK YGLFEITHQPELCAYVTRLPVEQYGVDAAILYKDIMTPLPSIGVDVEIKNGIGPVIDQ PIRSLADIEKLGQIDPEQDVPYVLETIKLLVNEQLNVPLIGFSGAPFTLASYMIEGGP SKNYNKTKAFMYSMPDAWNLLMSKLADMIIVYVKAQIEAGAKAIQIFDSWVGALNQAD YRTYIKPVMNRIFSELAKENVPLIMFGVGASHLAGDWHDLPLDVVGLDWRLGIDEARS KGITKTVQGNLDPSILLAPWEVIEQKTKEILDQGMESDGFIFNLGHGVFPDVSPEVLK KLTAFVHEYSQNKKMGQYS*" /label="hemE CDS" gene 1035694..1036755 /gene="hemE" /locus_tag="BSU_10120" /old_locus_tag="BSU10120" /label="hemE gene" CDS 1036827..1037759 /gene="hemH" /locus_tag="BSU_10130" /old_locus_tag="BSU10130" /EC_number="4.99.1.1" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:8119288, 12686546, 12761666, 16140324, 16453119, 17198378, 20543190, 21052751" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8119288, 12686546, 12761666, 16140324, 16453119, 17198378, 20543190, 21052751; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ferrochelatase" /protein_id="NP_388894.1" /db_xref="EnsemblGenomes-Gn:BSU10130" /db_xref="EnsemblGenomes-Tr:CAB12853" /db_xref="GOA:P32396" /db_xref="InterPro:IPR001015" /db_xref="InterPro:IPR019772" /db_xref="InterPro:IPR033644" /db_xref="InterPro:IPR033659" /db_xref="PDB:1AK1" /db_xref="PDB:1C1H" /db_xref="PDB:1C9E" /db_xref="PDB:1DOZ" /db_xref="PDB:1FJI" /db_xref="PDB:1LD3" /db_xref="PDB:1N0I" /db_xref="PDB:2AC2" /db_xref="PDB:2AC4" /db_xref="PDB:2H1V" /db_xref="PDB:2H1W" /db_xref="PDB:2HK6" /db_xref="PDB:2Q2N" /db_xref="PDB:2Q2O" /db_xref="PDB:2Q3J" /db_xref="PDB:3GOQ" /db_xref="PDB:3M4Z" /db_xref="SubtiList:BG10430" /db_xref="UniProtKB/Swiss-Prot:P32396" /translation="MSRKKMGLLVMAYGTPYKEEDIERYYTHIRRGRKPEPEMLQDLK DRYEAIGGISPLAQITEQQAHNLEQHLNEIQDEITFKAYIGLKHIEPFIEDAVAEMHK DGITEAVSIVLAPHFSTFSVQSYNKRAKEEAEKLGGLTITSVESWYDEPKFVTYWVDR VKETYASMPEDERENAMLIVSAHSLPEKIKEFGDPYPDQLHESAKLIAEGAGVSEYAV GWQSEGNTPDPWLGPDVQDLTRDLFEQKGYQAFVYVPVGFVADHLEVLYDNDYECKVV TDDIGASYYRPEMPNAKPEFIDALATVVLKKLGR*" /label="hemH CDS" gene 1036827..1037759 /gene="hemH" /locus_tag="BSU_10130" /old_locus_tag="BSU10130" /label="hemH gene" CDS 1037774..1039186 /gene="hemY" /locus_tag="BSU_10140" /old_locus_tag="BSU10140" /EC_number="1.3.3.4" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9217019, 9784236, 10498703, 20543190" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9217019, 9784236, 10498703, 20543190; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous protoporphyrinogen IX and coproporphyrinogen III oxidase" /protein_id="NP_388895.1" /db_xref="EnsemblGenomes-Gn:BSU10140" /db_xref="EnsemblGenomes-Tr:CAB12854" /db_xref="GOA:P32397" /db_xref="InterPro:IPR002937" /db_xref="InterPro:IPR004572" /db_xref="InterPro:IPR036188" /db_xref="PDB:3I6D" /db_xref="SubtiList:BG10431" /db_xref="UniProtKB/Swiss-Prot:P32397" /translation="MSDGKKHVVIIGGGITGLAAAFYMEKEIKEKNLPLELTLVEASP RVGGKIQTVKKDGYIIERGPDSFLERKKSAPQLVKDLGLEHLLVNNATGQSYVLVNRT LHPMPKGAVMGIPTKIAPFVSTGLFSLSGKARAAMDFILPASKTKDDQSLGEFFRRRV GDEVVENLIEPLLSGIYAGDIDKLSLMSTFPQFYQTEQKHRSLILGMKKTRPQGSGQQ LTAKKQGQFQTLSTGLQTLVEEIEKQLKLTKVYKGTKVTKLSHSGSCYSLELDNGVTL DADSVIVTAPHKAAAGMLSELPAISHLKNMHSTSVANVALGFPEGSVQMEHEGTGFVI SRNSDFAITACTWTNKKWPHAAPEGKTLLRAYVGKAGDESIVDLSDNDIINIVLEDLK KVMNINGEPEMTCVTRWHESMPQYHVGHKQRIKELREALASAYPGVYMTGASFEGVGI PDCIDQGKAAVSDALTYLFS*" /label="hemY CDS" gene 1037774..1039186 /gene="hemY" /locus_tag="BSU_10140" /old_locus_tag="BSU10140" /label="hemY gene" downshifts 1037777 /Source="Nicolas_upshifts" /id="D550" /incds=0 /nref=1 /ntot=19 /MaxReadThrough="7.68191" /MaxDrop="2.667" /score="28.7532434" /energy="-11.6" /TU="U813,U816" /idTUdmin="U814" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 1039163 /Source="Nicolas_upshifts" /id="D551" /incds=0 /nref=195 /ntot=254 /MaxReadThrough="2.9859" /MaxDrop="6.7703" /score="28.7532434" /energy="-11.6" /TU="NA" /idTUdmin="U813" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1039247..1039254 /Source="Nicolas_upshift_promotors" /id="U817" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.825174825174825" /psig=1 /xcortree=2648 /SigmaFactorBS="tttgatgtgcaatggcaatattgtgtaaaaaatgATTGAATT gaacagcaggttaTGATACATTTGCATATGTACttaatgactaaaatgttcaaacggt c" /listShort="yhgD, S358, yhgE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1039268..1039287 /Source="Nicolas_upshift_promotors" /id="U817" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.825174825174825" /psig=1 /xcortree=2648 /SigmaFactorBS="tttgatgtgcaatggcaatattgtgtaaaaaatgATTGAATT gaacagcaggttaTGATACATTTGCATATGTACttaatgactaaaatgttcaaacggt c" /listShort="yhgD, S358, yhgE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1039273 /Source="Nicolas_upshifts" /id="U817" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.825174825174825" /psig=1 /xcortree=2648 /SigmaFactorBS="tttgatgtgcaatggcaatattgtgtaaaaaatgATTGAATT gaacagcaggttaTGATACATTTGCATATGTACttaatgactaaaatgttcaaacggt c" /listShort="yhgD, S358, yhgE" /GFF_Attribute="listLong" /label="upshifts" CDS 1039332..1039907 /gene="yhgD" /locus_tag="BSU_10150" /old_locus_tag="BSU10150" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 15944459, 23695570; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of unknown target" /protein_id="NP_388896.1" /db_xref="EnsemblGenomes-Gn:BSU10150" /db_xref="EnsemblGenomes-Tr:CAB12855" /db_xref="GOA:P32398" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR023772" /db_xref="InterPro:IPR036271" /db_xref="SubtiList:BG10432" /db_xref="UniProtKB/Swiss-Prot:P32398" /translation="MSIDRKKLILEAATKSFTQFGYKATTMDLVAKLANVGKGTIYTF FKNKEELFDEIFTTLLKEMKQKADEAMEPSLPFHENVHRALFAILEFRKTHQLTIKIF QENAEIGTMAVQEVIQKMERSILSYIKSKIEDGIKSGAIKPCDPELTAFVMLKLYIAL IFDWEKQHPPLDKETIAGLLELYVVKGLSAN*" /label="yhgD CDS" gene 1039332..1039907 /gene="yhgD" /locus_tag="BSU_10150" /old_locus_tag="BSU10150" /label="yhgD gene" promotor_-35 1039651..1039654 /Source="Nicolas_upshift_promotors" /id="U818" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.731268731268731" /psig="0.731268731268731" /xcortree=140 /SigmaFactorBS="aaacacatcagctgacgattaaaattttccaagagaatgccg AGATtggtacaatggcagttCAGGAAGTGATCCAGAAAATggagcgatccatcctgtc t" /listShort="S358, yhgE" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1039669 /Source="Nicolas_upshifts" /id="U818" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.731268731268731" /psig="0.731268731268731" /xcortree=140 /SigmaFactorBS="aaacacatcagctgacgattaaaattttccaagagaatgccg AGATtggtacaatggcagttCAGGAAGTGATCCAGAAAATggagcgatccatcctgtc t" /listShort="S358, yhgE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1039671..1039690 /Source="Nicolas_upshift_promotors" /id="U818" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.731268731268731" /psig="0.731268731268731" /xcortree=140 /SigmaFactorBS="aaacacatcagctgacgattaaaattttccaagagaatgccg AGATtggtacaatggcagttCAGGAAGTGATCCAGAAAATggagcgatccatcctgtc t" /listShort="S358, yhgE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1039908..1039977 /Source="Nicolas_S_feature" /locus_tag="new_1090331_1090400" /HighExp="G135, G150, G180, BI, Salt, Etha, Cold, Heat, Oxctl, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigA" /TUshortPSig="0.731, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S358" CDS 1039978..1042305 /gene="yhgE" /locus_tag="BSU_10160" /old_locus_tag="BSU10160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15576783; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative methyl-accepting protein" /protein_id="NP_388897.1" /db_xref="EnsemblGenomes-Gn:BSU10160" /db_xref="EnsemblGenomes-Tr:CAB12856" /db_xref="GOA:P32399" /db_xref="InterPro:IPR017500" /db_xref="InterPro:IPR017501" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR023908" /db_xref="SubtiList:BG10433" /db_xref="UniProtKB/Swiss-Prot:P32399" /translation="MNTIRSQWKDIVTSKKLLIPIIAILFVPLIYSGVFLKAYWDPYG TVDQLPVVVVNQDKGATYEGEKLQIGDDLVKELKDNNNFDWHFSNDLDQSLKDLLNQK YYLVVEIPEDFSKNASTVLDKNPKKLDLKYHTNAGSNYVGATIGEKAIDKLKASVSKE VTEQYTKVIFDNFKDIAKGLSDASSGAKKIDDGTKDAKNGSAQLKENLAKLKESTATI SDKTAQLADGAAQVTSGIQSLDSSLGKFQDSSNQIYDKSSQLAAGSGELTSKMNELLA GLQNVQKGTPNLTNGLDQLNSKVQEGSEKAAKAEKIINALDLTKLETAVNNLEKSETA MKEFKKQLTDFENSLKNRDQAFKNVINSSDFLTAEQKSQLINSVEKKLPQVDAPDFDQ ILSQLPTADQLPDIATIKSSLEDVKAQVAQVKAMPEATSKLYNGAKTIQDAIDRLTEG ADKIYNGSQKLTDGQTKLTAGIGEYNKQFAKAKAGSEQLVTGSSQVSGGLFKLLDGSK QVQSGSSKLADGSASLDTGLGKLLDGTGELSSKLKDAADQTGDIDADDQTYGMFADPV KTKDDAIHSVPNYGTGLTPYILSMGLYVGGIMLTVVFPLKEASGRPRNGFEWFFSKFN VMMLVGIIQSLIVATVLLLGIGLEVESTWRFYVFTIITSLAFLAIIQFLATTMGNPGR FIAVIILVLQLGASGGTFPLELLPNFYQVIHGALPMTYSINGFRAVISNGDFGYMWQM AGVLIGIALVMIALSITYFTMLSRKEETSEEQPAS*" /label="yhgE CDS" gene 1039978..1042305 /gene="yhgE" /locus_tag="BSU_10160" /old_locus_tag="BSU10160" /label="yhgE gene" downshifts 1042287 /Source="Nicolas_upshifts" /id="D552" /incds=0 /nref=65 /ntot=211 /MaxReadThrough="0.57274" /MaxDrop="5.58483" /score="-4.79013797" /energy="-7.3" /TU="NA" /idTUdmin="U817" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1042347..1043324) /gene="fabHB" /locus_tag="BSU_10170" /old_locus_tag="BSU10170" /EC_number="2.3.1.180" /EC_number="2.3.1.38" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10629181, 21383089, 21542858" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10629181, 21383089, 21542858; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="beta-ketoacyl-acyl carrier protein synthase III 2" /protein_id="NP_388898.1" /db_xref="EnsemblGenomes-Gn:BSU10170" /db_xref="EnsemblGenomes-Tr:CAB12857" /db_xref="GOA:O07600" /db_xref="InterPro:IPR004655" /db_xref="InterPro:IPR013747" /db_xref="InterPro:IPR013751" /db_xref="InterPro:IPR016039" /db_xref="SubtiList:BG13048" /db_xref="UniProtKB/Swiss-Prot:O07600" /translation="MSKAKITAIGTYAPSRRLTNADLEKIVDTSDEWIVQRTGMRERR IADEHQFTSDLCIEAVKNLKSRYKGTLDDVDMILVATTTSDYAFPSTACRVQEYFGWE STGALDINATCAGLTYGLHLANGLITSGLHQKILVIAGETLSKVTDYTDRTTCVLFGD AAGALLVERDEETPGFLASVQGTSGNGGDILYRAGLRNEINGVQLVGSGKMVQNGREV YKWAARTVPGEFERLLHKAGLSSDDLDWFVPHSANLRMIESICEKTPFPIEKTLTSVE HYGNTSSVSIVLALDLAVKAGKLKKDQIVLLFGFGGGLTYTGLLIKWGM*" /label="fabHB CDS" gene complement(1042347..1043324) /gene="fabHB" /locus_tag="BSU_10170" /old_locus_tag="BSU10170" /label="fabHB gene" downshifts complement(1042360) /Source="Nicolas_upshifts" /id="D553" /incds=0 /nref=21 /ntot=217 /MaxReadThrough="1.99012" /MaxDrop="7.90433" /score="-9.17544275" /energy="-7.3" /TU="NA" /idTUdmin="U819" /TUdmin="-19" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1043338..1043357) /Source="Nicolas_upshift_promotors" /id="U819" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.466533466533467" /psig="0.999000999001" /xcortree=2184 /SigmaFactorBS="atctacacttctctttttttgtaaaaaaaccttctttttAGT ACCAgatactaatatctAGTGTTATAATCTGACCATAaggagtgattcatatgtcaaa a" /listShort="fabHB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1043356) /Source="Nicolas_upshifts" /id="U819" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.466533466533467" /psig="0.999000999001" /xcortree=2184 /SigmaFactorBS="atctacacttctctttttttgtaaaaaaaccttctttttAGT ACCAgatactaatatctAGTGTTATAATCTGACCATAaggagtgattcatatgtcaaa a" /listShort="fabHB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1043371..1043377) /Source="Nicolas_upshift_promotors" /id="U819" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.466533466533467" /psig="0.999000999001" /xcortree=2184 /SigmaFactorBS="atctacacttctctttttttgtaaaaaaaccttctttttAGT ACCAgatactaatatctAGTGTTATAATCTGACCATAaggagtgattcatatgtcaaa a" /listShort="fabHB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1043383..1043391 /Source="Nicolas_upshift_promotors" /id="U820" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3194 /SigmaFactorBS="tataacactagatattagtatctggtactaaaaaGAAGGTTT TtttacaaaaaAAGAGAAGTGTAGATAGGAatctatgaaaaagaaaaaggaggctgaa a" /listShort="yhfC, S360, yhfE, yhfF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1043402..1043420 /Source="Nicolas_upshift_promotors" /id="U820" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3194 /SigmaFactorBS="tataacactagatattagtatctggtactaaaaaGAAGGTTT TtttacaaaaaAAGAGAAGTGTAGATAGGAatctatgaaaaagaaaaaggaggctgaa a" /listShort="yhfC, S360, yhfE, yhfF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1043409 /Source="Nicolas_upshifts" /id="U820" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3194 /SigmaFactorBS="tataacactagatattagtatctggtactaaaaaGAAGGTTT TtttacaaaaaAAGAGAAGTGTAGATAGGAatctatgaaaaagaaaaaggaggctgaa a" /listShort="yhfC, S360, yhfE, yhfF" /GFF_Attribute="listLong" /label="upshifts" CDS 1043451..1044227 /gene="yhfC" /locus_tag="BSU_10180" /old_locus_tag="BSU10180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_388899.1" /db_xref="EnsemblGenomes-Gn:BSU10180" /db_xref="EnsemblGenomes-Tr:CAB12858" /db_xref="GOA:O07601" /db_xref="InterPro:IPR011397" /db_xref="SubtiList:BG13049" /db_xref="UniProtKB/Swiss-Prot:O07601" /translation="MVSQEAVVFLALSGAIAFLLPIGLIVWFKRKYGASLKVFFIGAL TFFVFAQLLEGGVHVYVLQVNEMTKEAMQHPLWYGIYGCLMAGIFEECGRYLMMRFFM KRHHTWADGLAFGAGHGGLEAILITGLSSISLIVYAFAINSGTFEQLLVNGDVKQALL PIQEQLLHTPSYEWMLGGIERISAIAVQIGLSLLVLYAVKNRRPLFLLYSILLHALFN VPAVLYQRGIIEHAAAVEIIVALIAALSVYWIVKAKRVFQ*" /label="yhfC CDS" gene 1043451..1044227 /gene="yhfC" /locus_tag="BSU_10180" /old_locus_tag="BSU10180" /label="yhfC gene" S_feature complement(1043943..1044564) /Source="Nicolas_S_feature" /locus_tag="new_1094366_1094987_c" /HighExp="B36, BT, B60, Pyr, S8, G/S, G135, Mal, M/G, Glucon" /AntisenseName="yhfC" /AntisenseCor="-0.12937903461570099" /AntisenseRegPval="-1.5" /CDS_PredictionProba="0.51248700000000003" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S359" S_feature 1044228..1044599 /Source="Nicolas_S_feature" /locus_tag="new_1094651_1095022" /HighExp="Lbstat, S2, M0t90, M40t90, HiOs, SMMPr, T-2.40H, Etha, Lbtran, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.48518699999999998" /TUshortSig="SigH" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S360" promotor_-10 complement(1044542..1044561) /Source="Nicolas_upshift_promotors" /id="U821" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1428 /SigmaFactorBS="tattttctacttaaaatatactcttttcccgagggacccGTC CAATCTTttcctatcaatctCTCATATGCTGTAGAGAGCAtgggaagaggagggattt c" /listShort="S359" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1044563) /Source="Nicolas_upshifts" /id="U821" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1428 /SigmaFactorBS="tattttctacttaaaatatactcttttcccgagggacccGTC CAATCTTttcctatcaatctCTCATATGCTGTAGAGAGCAtgggaagaggagggattt c" /listShort="S359" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1044575..1044584) /Source="Nicolas_upshift_promotors" /id="U821" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1428 /SigmaFactorBS="tattttctacttaaaatatactcttttcccgagggacccGTC CAATCTTttcctatcaatctCTCATATGCTGTAGAGAGCAtgggaagaggagggattt c" /listShort="S359" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1044577..1044584 /Source="Nicolas_upshift_promotors" /id="U822" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.78921078921079" /psig="0.96003996003996" /xcortree=2233 /SigmaFactorBS="atgctctctacagcatatgagagattgataggaaaaGATTGG ACgggtccctcgggaaAAGAGTATATTTTAAGTAGAaaataaaaggaggaatgcccta t" /listShort="yhfE, yhfF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1044599..1044618 /Source="Nicolas_upshift_promotors" /id="U822" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.78921078921079" /psig="0.96003996003996" /xcortree=2233 /SigmaFactorBS="atgctctctacagcatatgagagattgataggaaaaGATTGG ACgggtccctcgggaaAAGAGTATATTTTAAGTAGAaaataaaaggaggaatgcccta t" /listShort="yhfE, yhfF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1044601 /Source="Nicolas_upshifts" /id="U822" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.78921078921079" /psig="0.96003996003996" /xcortree=2233 /SigmaFactorBS="atgctctctacagcatatgagagattgataggaaaaGATTGG ACgggtccctcgggaaAAGAGTATATTTTAAGTAGAaaataaaaggaggaatgcccta t" /listShort="yhfE, yhfF" /GFF_Attribute="listLong" /label="upshifts" CDS 1044640..1045680 /gene="yhfE" /locus_tag="BSU_10200" /old_locus_tag="BSU10200" /EC_number="3.4.11.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15713475, 15743956; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aminopeptidase" /protein_id="NP_388901.1" /db_xref="EnsemblGenomes-Gn:BSU10200" /db_xref="EnsemblGenomes-Tr:CAB12860" /db_xref="GOA:O07603" /db_xref="InterPro:IPR008007" /db_xref="InterPro:IPR023367" /db_xref="SubtiList:BG13051" /db_xref="UniProtKB/Swiss-Prot:O07603" /translation="MTSVRKTMELIKELVSIPSPTGNTYEVINYIESLLKEWKVETVR NHKGGLIATLPGRDTSRHRMLTAHVDTLGAMVKEIKADGRLKIDLIGGFRYNSIEGEY CQIETASGKMYTGTILMHQTSVHVYKDAGKAERNQENMEIRLDEPVHCRKDTEELGIG VGDFVSFDPRVEITSSGFIKSRHLDDKASVALLLRLIHEIQTEDIELPYTTHFLISNN EEIGYGGNSNIPPETVEYLAVDMGAIGDGQATDEYSVSICVKDASGPYHYQLRKHLVQ LAEKHHIDYKLDIYPYYGSDASAAIKSGHDIVHGLIGPGIDASHAFERTHKSSLRHTA KLLYYYVQSPMV*" /label="yhfE CDS" gene 1044640..1045680 /gene="yhfE" /locus_tag="BSU_10200" /old_locus_tag="BSU10200" /label="yhfE gene" CDS 1045693..1046100 /gene="yhfF" /locus_tag="BSU_10210" /old_locus_tag="BSU10210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11157739, 14517985; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA-binding PUA-containing enzyme" /protein_id="NP_388902.1" /db_xref="EnsemblGenomes-Gn:BSU10210" /db_xref="EnsemblGenomes-Tr:CAB12861" /db_xref="InterPro:IPR007374" /db_xref="InterPro:IPR009326" /db_xref="InterPro:IPR015947" /db_xref="SubtiList:BG13052" /db_xref="UniProtKB/Swiss-Prot:O07604" /translation="MKIYKLKSTFGWEGDDGLGEQLIQQILAGEKSATCAPKSLYSKD ELRDVYQTAGQLVTVYDKHDNPRCNIKVTDVFETTFGAPDMRLVKGEGNGDRIEEFQE DHRMAWAELIKSGELELNEDTVLITELFVLVKD*" /label="yhfF CDS" gene 1045693..1046100 /gene="yhfF" /locus_tag="BSU_10210" /old_locus_tag="BSU10210" /label="yhfF gene" downshifts 1046071 /Source="Nicolas_upshifts" /id="D554" /incds=0 /nref=24 /ntot=228 /MaxReadThrough="0.87656" /MaxDrop="5.21108" /score="22.0862441" /energy="-20.3" /TU="U822" /idTUdmin="U822" /TUdmin="-23" /isTUend="FALSE" /label="downshifts" CDS complement(1046137..1047426) /gene="gltT" /locus_tag="BSU_10220" /old_locus_tag="BSU10220" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8634258, 10588697, 11148213, 15849754, 16850406, 17673229, 25344233" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8634258, 10588697, 11148213, 15849754, 16850406, 17673229, 25344233; Product type t: transporter" /codon_start=1 /transl_table=11 /product="proton/sodium-glutamate (aspartate) symport permease" /protein_id="NP_388903.1" /db_xref="EnsemblGenomes-Gn:BSU10220" /db_xref="EnsemblGenomes-Tr:CAB12862" /db_xref="GOA:O07605" /db_xref="InterPro:IPR001991" /db_xref="InterPro:IPR018107" /db_xref="InterPro:IPR033380" /db_xref="InterPro:IPR036458" /db_xref="SubtiList:BG12595" /db_xref="UniProtKB/Swiss-Prot:O07605" /translation="MKRIKFGLATQIFVGLILGVIVGVIWYGNPALPTYLQPIGDLFL RLIKMIVIPIVVSSLIIGVAGAGNGKQVGKLGFRTILYFEIITTFAIILGLALANIFH PGTGVNIHEAQKSDISQYVETEKEQSNKSVAETFLHIVPTNFFQSLVEGDLLAIICFT VLFALGISAIGERGKPVLAFFEGVSHAMFHVVNLVMKVAPFGVFALIGVTVSKFGLGS LISLGKLVGLVYVALAFFLIVIFGIVAKIAGISIFKFLAYMKDEILLAFSTSSSETVL PRIMEKMEKIGCPKGIVSFVIPIGYTFNLDGSVLYQSIAALFLAQVYGIDLTIWHQIT LVLVLMVTSKGMAAVPGTSFVVLLATLGTIGVPAEGLAFIAGVDRIMDMARTVVNLTG NALAAVVMSKWEGMFNPAKAETVMSQSKTEQNATISG*" /label="gltT CDS" gene complement(1046137..1047426) /gene="gltT" /locus_tag="BSU_10220" /old_locus_tag="BSU10220" /label="gltT gene" downshifts complement(1046167) /Source="Nicolas_upshifts" /id="D555" /incds=0 /nref=226 /ntot=280 /MaxReadThrough="2.99263" /MaxDrop="7.79183" /score="48.7726082" /energy="-21.9" /TU="U823" /idTUdmin="U824" /TUdmin=3 /isTUend="TRUE" /label="downshifts" S_feature complement(1047427..1047527) /Source="Nicolas_S_feature" /locus_tag="new_1097850_1097950_c" /HighExp="C90, LoTm, LBGexp, Cold, UNK1, BC, dia5, Lbexp, S1, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S361" promotor_-10 complement(1047526..1047545) /Source="Nicolas_upshift_promotors" /id="U823" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.556443556443556" /psig=1 /xcortree=2240 /SigmaFactorBS="tctggtgattatcataatgtcATTGAATattctttattttcg AAATATAATTTACTATAGACgaattgatttcttatctattataatttgatctaatagt g" /listShort="S361, gltT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1047527) /Source="Nicolas_upshifts" /id="U823" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.556443556443556" /psig=1 /xcortree=2240 /SigmaFactorBS="tctggtgattatcataatgtcATTGAATattctttattttcg AAATATAATTTACTATAGACgaattgatttcttatctattataatttgatctaatagt g" /listShort="S361, gltT" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1047529..1047665) /Source="Nicolas_S_feature" /locus_tag="new_1097952_1098088_c" /HighExp="M9-stat, T3.30H, T3.0H, T4.0H, T2.30H, T5.0H, Cold, T2.0H, S0, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S362" promotor_-35 complement(1047560..1047566) /Source="Nicolas_upshift_promotors" /id="U823" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.556443556443556" /psig=1 /xcortree=2240 /SigmaFactorBS="tctggtgattatcataatgtcATTGAATattctttattttcg AAATATAATTTACTATAGACgaattgatttcttatctattataatttgatctaatagt g" /listShort="S361, gltT" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1047697..1047837) /gene="yhfH" /locus_tag="BSU_10230" /old_locus_tag="BSU10230" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388904.1" /db_xref="EnsemblGenomes-Gn:BSU10230" /db_xref="EnsemblGenomes-Tr:CAB12863" /db_xref="InterPro:IPR025432" /db_xref="SubtiList:BG13053" /db_xref="UniProtKB/Swiss-Prot:O07606" /translation="MVMLGKITEFFRNLPSKKCAECGKKIEEQHECYGNICNDCIKVN DL*" /label="yhfH CDS" gene complement(1047697..1047837) /gene="yhfH" /locus_tag="BSU_10230" /old_locus_tag="BSU10230" /label="yhfH gene" downshifts complement(1047710) /Source="Nicolas_upshifts" /id="D556" /incds=0 /nref=3 /ntot=16 /MaxReadThrough="5.70702" /MaxDrop="4.73949" /score="28.7665297" /energy="-13.6" /TU="U824" /idTUdmin="U824" /TUdmin="-1540" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1047856..1047875) /Source="Nicolas_upshift_promotors" /id="U824" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.454545454545455" /psig=1 /xcortree=433 /SigmaFactorBS="tcttgaaaaaagcatgttttaaacattgtatcaaaacagtTA TTGATTtttgtaatctgtTATATTACAATGAAATCACTacaaaggggaaagagggatt g" /listShort="yhfH, S362, S361, gltT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1047875) /Source="Nicolas_upshifts" /id="U824" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.454545454545455" /psig=1 /xcortree=433 /SigmaFactorBS="tcttgaaaaaagcatgttttaaacattgtatcaaaacagtTA TTGATTtttgtaatctgtTATATTACAATGAAATCACTacaaaggggaaagagggatt g" /listShort="yhfH, S362, S361, gltT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1047888..1047895) /Source="Nicolas_upshift_promotors" /id="U824" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.454545454545455" /psig=1 /xcortree=433 /SigmaFactorBS="tcttgaaaaaagcatgttttaaacattgtatcaaaacagtTA TTGATTtttgtaatctgtTATATTACAATGAAATCACTacaaaggggaaagagggatt g" /listShort="yhfH, S362, S361, gltT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1047919..1047925 /Source="Nicolas_upshift_promotors" /id="U825" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.621378621378621" /psig="0.99100899100899" /xcortree=1999 /SigmaFactorBS="tacaaaaatcaataactgttttgatacaatgtttaaaACATG CTtttttcaagaaaaATGGGTATATTGAAGGAGGAccaatttttttgaaaagatagga g" /listShort="yhfI, yhfJ, yhfK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1047939..1047958 /Source="Nicolas_upshift_promotors" /id="U825" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.621378621378621" /psig="0.99100899100899" /xcortree=1999 /SigmaFactorBS="tacaaaaatcaataactgttttgatacaatgtttaaaACATG CTtttttcaagaaaaATGGGTATATTGAAGGAGGAccaatttttttgaaaagatagga g" /listShort="yhfI, yhfJ, yhfK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1047942 /Source="Nicolas_upshifts" /id="U825" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.621378621378621" /psig="0.99100899100899" /xcortree=1999 /SigmaFactorBS="tacaaaaatcaataactgttttgatacaatgtttaaaACATG CTtttttcaagaaaaATGGGTATATTGAAGGAGGAccaatttttttgaaaagatagga g" /listShort="yhfI, yhfJ, yhfK" /GFF_Attribute="listLong" /label="upshifts" CDS 1047989..1048723 /gene="yhfI" /locus_tag="BSU_10240" /old_locus_tag="BSU10240" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent hydrolase" /protein_id="NP_388905.1" /db_xref="EnsemblGenomes-Gn:BSU10240" /db_xref="EnsemblGenomes-Tr:CAB12864" /db_xref="GOA:O07607" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG13054" /db_xref="UniProtKB/Swiss-Prot:O07607" /translation="MKVTVIGCYGGFPAANEATSGYLFQSGDYSLLVDCGSAVLSKLF GYVPAEKLDAVVLSHYHHDHIADIGPLQFAKQVGSFLGKGEHTLPIYGHDADIEQFQK LTYKTHTKGIAYQPDQPLTAGPFTITFLKTIHPVTCYAMRITDGSHTVVYTADSSYQD SFIPFSKDADLLISECNFYADQDGTSAGHMNSLEAGRIAKEAGAGELLLTHLPHFGVH DNLRKEAKTVFNGEVNIAKSGFVWEG*" /label="yhfI CDS" gene 1047989..1048723 /gene="yhfI" /locus_tag="BSU_10240" /old_locus_tag="BSU10240" /label="yhfI gene" CDS 1048736..1049731 /gene="lplJ" /locus_tag="BSU_10250" /old_locus_tag="BSU10250" /EC_number="6.3.1.20" /experiment="publication(s) with functional evidences, PMID:21338420, 21338421" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21338420, 21338421; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="lipoate-protein ligase" /protein_id="NP_388906.1" /db_xref="EnsemblGenomes-Gn:BSU10250" /db_xref="EnsemblGenomes-Tr:CAB12865" /db_xref="GOA:O07608" /db_xref="InterPro:IPR004143" /db_xref="InterPro:IPR004562" /db_xref="InterPro:IPR019491" /db_xref="SubtiList:BG13055" /db_xref="UniProtKB/Swiss-Prot:O07608" /translation="MLFIDNQNINDPRINLAIEEYCVKHLDPEQQYLLFYVNQPSIII GKNQNTIEEINTKYVEENGIIVVRRLSGGGAVYHDLGNLNFSFITKDDGDSFHNFKKF TEPVIQALHQLGVEAELSGRNDIVVDGRKISGNAQFATKGRIFSHGTLMFDSAIDHVV SALKVKKDKIESKGIKSIRSRVANISEFLDDKMTTEEFRSHLLRHIFNTNDVGNVPEY KLTEKDWETIHQISKERYQNWDWNYGRSPKFNLNHSKRYPVGSIDLHLEVKKGKIEDC KIFGDFFGVGDVSEIENLLVGKQYERSVIADVLEGVNLKHYFGNITKEDFLDLIY*" /label="lplJ CDS" gene 1048736..1049731 /gene="lplJ" /locus_tag="BSU_10250" /old_locus_tag="BSU10250" /label="lplJ gene" CDS 1049796..1050440 /gene="yhfK" /locus_tag="BSU_10260" /old_locus_tag="BSU10260" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11790741; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NAD-binding epimerase / hydratase" /protein_id="NP_388907.1" /db_xref="EnsemblGenomes-Gn:BSU10260" /db_xref="EnsemblGenomes-Tr:CAB12866" /db_xref="GOA:O07609" /db_xref="InterPro:IPR016040" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13056" /db_xref="UniProtKB/Swiss-Prot:O07609" /translation="MKVFLIGANGQIGQRLVSLFQDNPDHSIRAMVRKEEQKASLEAA GAEAVLANLEGSPEEIAAAAKGCDAIIFTAGSGGSTGYDKTLLVDLDGAAKAIEAAAI AGIKRFIMVSALQAHNRENWNEALKPYYVAKHYADKILEASGLTYTIIRPGGLRNEPG TGTVSAAKDLERGFISRDDVAKTVIASLDEKNTENRAFDLTEGDTPIAEALKKL*" /label="yhfK CDS" gene 1049796..1050440 /gene="yhfK" /locus_tag="BSU_10260" /old_locus_tag="BSU10260" /label="yhfK gene" downshifts 1050428 /Source="Nicolas_upshifts" /id="D557" /incds=0 /nref=239 /ntot=258 /MaxReadThrough="0.56809" /MaxDrop="6.84076" /score="18.2092404" /energy="-10" /TU="NA" /idTUdmin="U825" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1050468..1050471 /Source="Nicolas_upshift_promotors" /id="U826" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.619380619380619" /psig=1 /xcortree=374 /SigmaFactorBS="aactatgacagtactgacactcagggctttttgctCTTGagt gtttttttctgTTTCTCTATAATGGAGAAGAaagcttggcttcaataatgaatgacta t" /listShort="lcfB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1050486..1050505 /Source="Nicolas_upshift_promotors" /id="U826" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.619380619380619" /psig=1 /xcortree=374 /SigmaFactorBS="aactatgacagtactgacactcagggctttttgctCTTGagt gtttttttctgTTTCTCTATAATGGAGAAGAaagcttggcttcaataatgaatgacta t" /listShort="lcfB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1050493 /Source="Nicolas_upshifts" /id="U826" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.619380619380619" /psig=1 /xcortree=374 /SigmaFactorBS="aactatgacagtactgacactcagggctttttgctCTTGagt gtttttttctgTTTCTCTATAATGGAGAAGAaagcttggcttcaataatgaatgacta t" /listShort="lcfB" /GFF_Attribute="listLong" /label="upshifts" CDS 1050557..1052098 /gene="lcfB" /locus_tag="BSU_10270" /old_locus_tag="BSU10270" /EC_number="6.2.1.3" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17189250, 21398533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17189250, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="long-chain fatty-acid-CoA ligase (degradative)" /protein_id="NP_388908.2" /db_xref="EnsemblGenomes-Gn:BSU10270" /db_xref="EnsemblGenomes-Tr:CAB12867" /db_xref="GOA:O07610" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR020459" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="SubtiList:BG13057" /db_xref="UniProtKB/Swiss-Prot:O07610" /translation="MNLVSKLEETASEKPDSIACRFKDHMMTYQELNEYIQRFADGLQ EAGMEKGDHLALLLGNSPDFIIAFFGALKAGIVVVPINPLYTPTEIGYMLTNGDVKAI VGVSQLLPLYESMHESLPKVELVILCQTGEAEPEAADPEVRMKMTTFAKILRPTSAAK QNQEPVPDDTAVILYTSGTTGKPKGAMLTHQNLYSNANDVAGYLGMDERDNVVCALPM FHVFCLTVCMNAPLMSGATVLIEPQFSPASVFKLVKQQQATIFAGVPTMYNYLFQHEN GKKDDFSSIRLCISGGASMPVALLTAFEEKFGVTILEGYGLSEASPVTCFNPFDRGRK PGSIGTSILHVENKVVDPLGRELPAHQVGELIVKGPNVMKGYYKMPMETEHALKDGWL YTGDLARRDEDGYFYIVDRKKDMIIVGGYNVYPREVEEVLYSHPDVKEAVVIGVPDPQ SGEAVKGYVVPKRSGVTEEDIMQHCEKHLAKYKRPAAITFLDDIPKNATGKMLRRALR DILPQ*" /label="lcfB CDS" gene 1050557..1052098 /gene="lcfB" /locus_tag="BSU_10270" /old_locus_tag="BSU10270" /label="lcfB gene" downshifts 1052078 /Source="Nicolas_upshifts" /id="D558" /incds=0 /nref=5 /ntot=108 /MaxReadThrough="2.74134" /MaxDrop="3.72638" /score="15.3712924" /energy="-10.4" /TU="NA" /idTUdmin="U826" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1052137..1052532) /gene="yhfM" /locus_tag="BSU_10280" /old_locus_tag="BSU10280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="NP_388909.1" /db_xref="EnsemblGenomes-Gn:BSU10280" /db_xref="EnsemblGenomes-Tr:CAB12868" /db_xref="SubtiList:BG13058" /db_xref="UniProtKB/Swiss-Prot:O07611" /translation="MKKIVAAIVVIGLVFIAFFYLYSRSGDVYQSVDADLITLSSSGQ EDIEIEKRQHVKDMLDIMNQGKQVKTEKTSAPDYEGTIKFHKDRYDSFRLWIDGSQQA VFLKDGTYYKLSKNDTKALLNIIKKEAKD*" /label="yhfM CDS" gene complement(1052137..1052532) /gene="yhfM" /locus_tag="BSU_10280" /old_locus_tag="BSU10280" /label="yhfM gene" downshifts complement(1052154) /Source="Nicolas_upshifts" /id="D559" /incds=0 /nref=46 /ntot=89 /MaxReadThrough="0.75539" /MaxDrop="6.88759" /score="17.4775611" /energy="-10.4" /TU="NA" /idTUdmin="U827" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1052552..1052563) /Source="Nicolas_upshift_promotors" /id="U827" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1141 /SigmaFactorBS="caagctgtgttccgcacttttccacccttttaAGCATGGaaa ccccgatcgctGGGAAAACTAACaatgtttggagtgatgcaaatgaaaaaaatagtgg c" /listShort="yhfM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1052556) /Source="Nicolas_upshifts" /id="U827" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1141 /SigmaFactorBS="caagctgtgttccgcacttttccacccttttaAGCATGGaaa ccccgatcgctGGGAAAACTAACaatgtttggagtgatgcaaatgaaaaaaatagtgg c" /listShort="yhfM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1052578..1052584) /Source="Nicolas_upshift_promotors" /id="U827" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1141 /SigmaFactorBS="caagctgtgttccgcacttttccacccttttaAGCATGGaaa ccccgatcgctGGGAAAACTAACaatgtttggagtgatgcaaatgaaaaaaatagtgg c" /listShort="yhfM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1052617..1052620 /Source="Nicolas_upshift_promotors" /id="U828" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.635364635364635" /psig="0.785214785214785" /xcortree=1404 /SigmaFactorBS="atcggggtttccatgcttaaaagggtggaaaagtgcggaaca cagcttgGTTCtaagaatttgaattTATGATTACAATAGAAGTAAcgggttgatgtga g" /listShort="yhfN" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1052628 /Source="Nicolas_upshifts" /id="U828" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.635364635364635" /psig="0.785214785214785" /xcortree=1404 /SigmaFactorBS="atcggggtttccatgcttaaaagggtggaaaagtgcggaaca cagcttgGTTCtaagaatttgaattTATGATTACAATAGAAGTAAcgggttgatgtga g" /listShort="yhfN" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1052635..1052654 /Source="Nicolas_upshift_promotors" /id="U828" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.635364635364635" /psig="0.785214785214785" /xcortree=1404 /SigmaFactorBS="atcggggtttccatgcttaaaagggtggaaaagtgcggaaca cagcttgGTTCtaagaatttgaattTATGATTACAATAGAAGTAAcgggttgatgtga g" /listShort="yhfN" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1052681..1053961 /gene="yhfN" /locus_tag="BSU_10290" /old_locus_tag="BSU10290" /EC_number="3.4.24.84" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9015299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane metalloprotease" /protein_id="NP_388910.1" /db_xref="EnsemblGenomes-Gn:BSU10290" /db_xref="EnsemblGenomes-Tr:CAB12869" /db_xref="GOA:P40769" /db_xref="InterPro:IPR001915" /db_xref="InterPro:IPR027057" /db_xref="InterPro:IPR032456" /db_xref="SubtiList:BG11029" /db_xref="UniProtKB/Swiss-Prot:P40769" /translation="MRKWIAAAGLAYVLYGLFFYWYFFLSGDSAIPEAVKGTQADPAS FMKPSELAVAEQYSNVKNFLFFIGVPLDWFLFFVLLVSGVSKKIKKWIEAAVPFRFLQ TVGFVFVLSLITTLVTLPLDWIGYQVSLDYNISTQTTASWAKDQVISFWISFPIFTLC VLVFYWLIKRHEKKWWLYAWLLTVPFSLFLFFIQPVIIDPLYNDFYPLKNKELESKIL ELADEANIPADHVYEVNMSEKTNALNAYVTGIGANKRIVLWDTTLNKLDDSEILFIMG HEMGHYVMKHVYIGLAGYLLVSLAGFYVIDKLYKRTVRLTRSMFHLEGRHDLAALPLL LLLFSVLSFAVTPFSNAVSRYQENKADQYGIELTENREAAVKTFQDLAVTGLSQVDPP VLVKIFRGSHPSIMERIQHAEKEENAPEHQDADK*" /label="yhfN CDS" gene 1052681..1053961 /gene="yhfN" /locus_tag="BSU_10290" /old_locus_tag="BSU10290" /label="yhfN gene" promotor_-10 complement(1053108..1053127) /Source="Nicolas_upshift_promotors" /id="U829" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.574425574425574" /psig="0.974025974025974" /xcortree=1821 /SigmaFactorBS="tcagccaataaaaaacgagaacgcaaagcgtaaaGATTGGaa agctgatccaaaaGCTGATAACCTGATCCTTAGcccagctggccgttgtctgtgtgga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1053122) /Source="Nicolas_upshifts" /id="U829" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.574425574425574" /psig="0.974025974025974" /xcortree=1821 /SigmaFactorBS="tcagccaataaaaaacgagaacgcaaagcgtaaaGATTGGaa agctgatccaaaaGCTGATAACCTGATCCTTAGcccagctggccgttgtctgtgtgga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1053143..1053148) /Source="Nicolas_upshift_promotors" /id="U829" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.574425574425574" /psig="0.974025974025974" /xcortree=1821 /SigmaFactorBS="tcagccaataaaaaacgagaacgcaaagcgtaaaGATTGGaa agctgatccaaaaGCTGATAACCTGATCCTTAGcccagctggccgttgtctgtgtgga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1053948 /Source="Nicolas_upshifts" /id="D560" /incds=0 /nref=2 /ntot=57 /MaxReadThrough="3.82026" /MaxDrop="3.6342" /score="6.45541384" /energy="-12.7" /TU="U828" /idTUdmin="U828" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" downshifts complement(1053998) /Source="Nicolas_upshifts" /id="D561" /incds=0 /nref=129 /ntot=219 /MaxReadThrough="-0.11848" /MaxDrop="9.02627" /score="-6.76069514" /energy="-7.8" /TU="NA" /idTUdmin="U830" /TUdmin=4 /isTUend="TRUE" /label="downshifts" CDS complement(1054000..1055145) /gene="aprE" /locus_tag="BSU_10300" /old_locus_tag="BSU10300" /EC_number="3.4.21.62" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:3108260, 9811547, 12950930, 14688235, 15205417, 17666034, 19710937, 26728191" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3108260, 9811547, 12950930, 14688235, 15205417, 17666034, 19710937, 26728191; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="serine alkaline protease (Ca(2+)-dependent subtilisin E)" /protein_id="NP_388911.2" /db_xref="EnsemblGenomes-Gn:BSU10300" /db_xref="EnsemblGenomes-Tr:CAB12870" /db_xref="GOA:P04189" /db_xref="InterPro:IPR000209" /db_xref="InterPro:IPR009020" /db_xref="InterPro:IPR010259" /db_xref="InterPro:IPR015500" /db_xref="InterPro:IPR022398" /db_xref="InterPro:IPR023827" /db_xref="InterPro:IPR023828" /db_xref="InterPro:IPR034202" /db_xref="InterPro:IPR036852" /db_xref="InterPro:IPR037045" /db_xref="PDB:1SCJ" /db_xref="PDB:3WHI" /db_xref="SubtiList:BG10190" /db_xref="UniProtKB/Swiss-Prot:P04189" /translation="MRSKKLWISLLFALTLIFTMAFSNMSAQAAGKSSTEKKYIVGFK QTMSAMSSAKKKDVISEKGGKVQKQFKYVNAAAATLDEKAVKELKKDPSVAYVEEDHI AHEYAQSVPYGISQIKAPALHSQGYTGSNVKVAVIDSGIDSSHPDLNVRGGASFVPSE TNPYQDGSSHGTHVAGTIAALNNSIGVLGVAPSASLYAVKVLDSTGSGQYSWIINGIE WAISNNMDVINMSLGGPTGSTALKTVVDKAVSSGIVVAAAAGNEGSSGSTSTVGYPAK YPSTIAVGAVNSSNQRASFSSAGSELDVMAPGVSIQSTLPGGTYGAYNGTSMATPHVA GAAALILSKHPTWTNAQVRDRLESTATYLGNSFYYGKGLINVQAAAQ*" /label="aprE CDS" gene complement(1054000..1055145) /gene="aprE" /locus_tag="BSU_10300" /old_locus_tag="BSU10300" /label="aprE gene" S_feature complement(1055146..1055212) /Source="Nicolas_S_feature" /locus_tag="new_1105569_1105635_c" /HighExp="BC, T5.0H, LoTm, Sw, T4.0H, T3.30H, S1, T3.0H, S2, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S363" promotor_-10 complement(1055201..1055220) /Source="Nicolas_upshift_promotors" /id="U830" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=468 /SigmaFactorBS="atacctaaatagagataaaatcatctcaaaaaaatgggTCTA CtaaaatattattccaTCTATTACAATAAATTCACAgaatagtcttttaagtaagtct a" /listShort="S363, aprE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1055218) /Source="Nicolas_upshifts" /id="U830" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=468 /SigmaFactorBS="atacctaaatagagataaaatcatctcaaaaaaatgggTCTA CtaaaatattattccaTCTATTACAATAAATTCACAgaatagtcttttaagtaagtct a" /listShort="S363, aprE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1055236..1055240) /Source="Nicolas_upshift_promotors" /id="U830" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=468 /SigmaFactorBS="atacctaaatagagataaaatcatctcaaaaaaatgggTCTA CtaaaatattattccaTCTATTACAATAAATTCACAgaatagtcttttaagtaagtct a" /listShort="S363, aprE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1055525..1055532 /Source="Nicolas_upshift_promotors" /id="U831" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.854145854145854" /psig="0.983016983016983" /xcortree=2175 /SigmaFactorBS="ttcaaagcatgatgataaaagtattctgaaaaataaACTTTA CAgaaaagggatagaaTGAAAAAATTATTGAGAGGGaggaagaaataagatgaacatt c" /listShort="yhfO, yhfP, S364" /listLong="yhfQ" /label="promotor_-35" promotor_-10 1055547..1055566 /Source="Nicolas_upshift_promotors" /id="U831" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.854145854145854" /psig="0.983016983016983" /xcortree=2175 /SigmaFactorBS="ttcaaagcatgatgataaaagtattctgaaaaataaACTTTA CAgaaaagggatagaaTGAAAAAATTATTGAGAGGGaggaagaaataagatgaacatt c" /listShort="yhfO, yhfP, S364" /listLong="yhfQ" /label="promotor_-10" upshifts 1055549 /Source="Nicolas_upshifts" /id="U831" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.854145854145854" /psig="0.983016983016983" /xcortree=2175 /SigmaFactorBS="ttcaaagcatgatgataaaagtattctgaaaaataaACTTTA CAgaaaagggatagaaTGAAAAAATTATTGAGAGGGaggaagaaataagatgaacatt c" /listShort="yhfO, yhfP, S364" /listLong="yhfQ" /label="upshifts" CDS 1055580..1056029 /gene="yhfO" /locus_tag="BSU_10310" /old_locus_tag="BSU10310" /EC_number="2.3.1.-" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11717295; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_388912.1" /db_xref="EnsemblGenomes-Gn:BSU10310" /db_xref="EnsemblGenomes-Tr:CAB12871" /db_xref="GOA:O07614" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13059" /db_xref="UniProtKB/Swiss-Prot:O07614" /translation="MNIRQAKTSDAAAIAPLFNQYREFYRQASDLQGAEAFLKARLEN HESVILIAEENGEFIGFTQLYPTFSSVSMKRIYILNDLFVVPHARTKGAGGRLLSAAK DYAGQNGAKCLTLQTEHHNRKARSLYEQNGYEEDTGFVHYCLNVPAK*" /label="yhfO CDS" gene 1055580..1056029 /gene="yhfO" /locus_tag="BSU_10310" /old_locus_tag="BSU10310" /label="yhfO gene" promotor_-35 1056045..1056052 /Source="Nicolas_upshift_promotors" /id="U832" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2061 /SigmaFactorBS="tgtgccggcgaagtgaaaatggcggcttgatGATTTGGTttt ttgaacgttctTCGGTTACGATATAAATGAAaaggagtgtgccgaatgtcaacgttat t" /listShort="yhfP, S364, yhfQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1056067..1056086 /Source="Nicolas_upshift_promotors" /id="U832" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2061 /SigmaFactorBS="tgtgccggcgaagtgaaaatggcggcttgatGATTTGGTttt ttgaacgttctTCGGTTACGATATAAATGAAaaggagtgtgccgaatgtcaacgttat t" /listShort="yhfP, S364, yhfQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1056074 /Source="Nicolas_upshifts" /id="U832" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig=1 /xcortree=2061 /SigmaFactorBS="tgtgccggcgaagtgaaaatggcggcttgatGATTTGGTttt ttgaacgttctTCGGTTACGATATAAATGAAaaggagtgtgccgaatgtcaacgttat t" /listShort="yhfP, S364, yhfQ" /GFF_Attribute="listLong" /label="upshifts" CDS 1056101..1057093 /gene="yhfP" /locus_tag="BSU_10320" /old_locus_tag="BSU10320" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9643546, 12057962; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388913.1" /db_xref="EnsemblGenomes-Gn:BSU10320" /db_xref="EnsemblGenomes-Tr:CAB12872" /db_xref="GOA:O07615" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR014188" /db_xref="InterPro:IPR020843" /db_xref="InterPro:IPR036291" /db_xref="PDB:1TT7" /db_xref="PDB:1Y9E" /db_xref="SubtiList:BG13060" /db_xref="UniProtKB/Swiss-Prot:O07615" /translation="MSTLFQALQAEKNADDVSVHVKTISTEDLPKDGVLIKVAYSGIN YKDGLAGKAGGNIVREYPLILGIDAAGTVVSSNDPRFAEGDEVIATSYELGVSRDGGL SEYASVPGDWLVPLPQNLSLKEAMVYGTAGFTAALSVHRLEQNGLSPEKGSVLVTGAT GGVGGIAVSMLNKRGYDVVASTGNREAADYLKQLGASEVISREDVYDGTLKALSKQQW QGAVDPVGGKQLASLLSKIQYGGSVAVSGLTGGGEVPATVYPFILRGVSLLGIDSVYC PMDVRAAVWERMSSDLKPDQLLTIVDREVSLEETPGALKDILQNRIQGRVIVKL*" /label="yhfP CDS" gene 1056101..1057093 /gene="yhfP" /locus_tag="BSU_10320" /old_locus_tag="BSU10320" /label="yhfP gene" downshifts 1057094 /Source="Nicolas_upshifts" /id="D562" /incds=0 /nref=1 /ntot=37 /MaxReadThrough="4.4421" /MaxDrop="2.9095" /score="14.183693" /energy="-15.3" /TU="U831,U832" /idTUdmin="U831" /TUdmin="-154" /isTUend="FALSE" /label="downshifts" S_feature 1057139..1057249 /Source="Nicolas_S_feature" /locus_tag="new_1107562_1107672" /HighExp="Etha, dia15, LoTm, Salt, H2O2, LBGexp, Diami, Paraq, dia5, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.983" /TUlongSig="NA" /TUlongPSig="NA" /label="S364" promotor_-35 1057227..1057234 /Source="Nicolas_upshift_promotors" /id="U833" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.76023976023976" /psig=1 /xcortree=2107 /SigmaFactorBS="gtaagccgaactttctcttctcattttaaaaataatTGGTGA TAatgattctcattccgTGTTATACTACTCTTGGACAtcttaaccatagaaactacca a" /listShort="yhfQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1057250..1057269 /Source="Nicolas_upshift_promotors" /id="U833" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.76023976023976" /psig=1 /xcortree=2107 /SigmaFactorBS="gtaagccgaactttctcttctcattttaaaaataatTGGTGA TAatgattctcattccgTGTTATACTACTCTTGGACAtcttaaccatagaaactacca a" /listShort="yhfQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1057251 /Source="Nicolas_upshifts" /id="U833" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.76023976023976" /psig=1 /xcortree=2107 /SigmaFactorBS="gtaagccgaactttctcttctcattttaaaaataatTGGTGA TAatgattctcattccgTGTTATACTACTCTTGGACAtcttaaccatagaaactacca a" /listShort="yhfQ" /GFF_Attribute="listLong" /label="upshifts" CDS 1057310..1058281 /gene="yhfQ" /locus_tag="BSU_10330" /old_locus_tag="BSU10330" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12354229, 16672620, 20147287; Product type t: transporter" /codon_start=1 /transl_table=11 /product="iron(III) siderophore-binding lipoprotein" /protein_id="NP_388914.2" /db_xref="EnsemblGenomes-Gn:BSU10330" /db_xref="EnsemblGenomes-Tr:CAB12873" /db_xref="GOA:C0SP94" /db_xref="InterPro:IPR002491" /db_xref="SubtiList:BG13061" /db_xref="UniProtKB/Swiss-Prot:C0SP94" /translation="MKKTLIILTVLLLSVLTAACSSSSGNQNSKEHKVAVTHDLGKTN VPEHPKRVVVLELGFIDTLLDLGITPVGVADDNKAKQLINKDVLKKIDGYTSVGTRSQ PSMEKIASLKPDLIIADTTRHKKVYDQLKKIAPTIALNNLNADYQDTIDASLTIAKAV GKEKEMEKKLTAHEEKLSETKQKISANSQSVLLIGNTNDTIMARDENFFTSRLLTQVG YRYAISTSGNSDSSNGGDSVNMKMTLEQLLKTDPDVIILMTGKTDDLDADGKRPIEKN VLWKKLKAVKNGHVYHVDRAVWSLRRSVDGANAILDELQKEMPAAKK*" /label="yhfQ CDS" gene 1057310..1058281 /gene="yhfQ" /locus_tag="BSU_10330" /old_locus_tag="BSU10330" /label="yhfQ gene" downshifts 1058260 /Source="Nicolas_upshifts" /id="D563" /incds=0 /nref=172 /ntot=251 /MaxReadThrough="2.22013" /MaxDrop="5.6726" /score="27.9181244" /energy="-10.9" /TU="NA" /idTUdmin="U833" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1058313..1058894) /gene="phoE" /locus_tag="BSU_10340" /old_locus_tag="BSU10340" /EC_number="3.1.3.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10869096, 11827481, 12870714, 17693564" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10869096, 11827481, 12870714, 17693564; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous phosphatase; putative (phosphoglycerate) mutase" /protein_id="NP_388915.1" /db_xref="EnsemblGenomes-Gn:BSU10340" /db_xref="EnsemblGenomes-Tr:CAB12874" /db_xref="GOA:O07617" /db_xref="InterPro:IPR001345" /db_xref="InterPro:IPR013078" /db_xref="InterPro:IPR029033" /db_xref="SubtiList:BG13062" /db_xref="UniProtKB/Swiss-Prot:O07617" /translation="MTAVCLVRHGETDWNLQQKCQGKTDIPLNATGERQARETGEYVK DFSWDIIVTSPLKRAKRTAEIINEYLHLPIVEMDDFKERDYGDAEGMPLEERTKRYPD NIYPNMETLEELTDRLMGGLAKVNQAYPNKKVLIVAHGAAIHALLTEISGGDPELQST RLVNACLSNIEFAEEKWRIKDYNINSHLSGFIK*" /label="phoE CDS" gene complement(1058313..1058894) /gene="phoE" /locus_tag="BSU_10340" /old_locus_tag="BSU10340" /label="phoE gene" downshifts complement(1058336) /Source="Nicolas_upshifts" /id="D564" /incds=0 /nref=218 /ntot=256 /MaxReadThrough="1.23197" /MaxDrop="6.359" /score="28.9228703" /energy="-10.9" /TU="NA" /idTUdmin="U834" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1058918..1058937) /Source="Nicolas_upshift_promotors" /id="U834" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.370629370629371" /psig="0.998001998001998" /xcortree=1973 /SigmaFactorBS="ctttattatttgaagttcttgcataggctttttcATAGgaca cacgctttcgaTTTAGTATAATAGCGATATGaataaagtcaggaaggggattttatga c" /listShort="phoE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1058930) /Source="Nicolas_upshifts" /id="U834" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.370629370629371" /psig="0.998001998001998" /xcortree=1973 /SigmaFactorBS="ctttattatttgaagttcttgcataggctttttcATAGgaca cacgctttcgaTTTAGTATAATAGCGATATGaataaagtcaggaaggggattttatga c" /listShort="phoE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1058953..1058956) /Source="Nicolas_upshift_promotors" /id="U834" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.370629370629371" /psig="0.998001998001998" /xcortree=1973 /SigmaFactorBS="ctttattatttgaagttcttgcataggctttttcATAGgaca cacgctttcgaTTTAGTATAATAGCGATATGaataaagtcaggaaggggattttatga c" /listShort="phoE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1058965..1060059) /gene="yhfS" /locus_tag="BSU_10350" /old_locus_tag="BSU10350" /EC_number="2.3.1.9" /experiment="publication(s) with functional evidences, PMID:12368242, 23840410" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12368242, 23840410; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetyl-CoA C-acetyltransferase" /protein_id="NP_388916.1" /db_xref="EnsemblGenomes-Gn:BSU10350" /db_xref="EnsemblGenomes-Tr:CAB12875" /db_xref="GOA:O07618" /db_xref="InterPro:IPR002155" /db_xref="InterPro:IPR016039" /db_xref="InterPro:IPR020613" /db_xref="InterPro:IPR020616" /db_xref="InterPro:IPR020617" /db_xref="SubtiList:BG13063" /db_xref="UniProtKB/Swiss-Prot:O07618" /translation="MNAVIVDAKRTIFGNQNGLLKPFLPEDLAAPIIRCLSRKLEDQV DEVILGNATGRGGNLARLSALQAGLPLSVPGMTIDRQCGSGLEAVRYACSLIQAGAGT MYIAGGSESSSQSPFSERARFSPDAIGDPDMGIAAEYTAARYSISRSMQDEYALLSHQ RSRNAHDEGFYREEVVALGELETDEAFLKTRPIEAIIPRAKPVFDTSSGTVTAANSSG IADGAAALLVMEEEKAAALGLKPVLRFIGSAVSGIHPNFPPAAPVVAIRQLLHTHDVT PDDIDLFEINEAFAVKICVCSQELGIPFSKINVRGGALALGHPYGASGAALVTRLFYE AKRRPDCQYAVAAIGSGGGIGLALLFEVLA*" /label="yhfS CDS" gene complement(1058965..1060059) /gene="yhfS" /locus_tag="BSU_10350" /old_locus_tag="BSU10350" /label="yhfS gene" CDS complement(1060056..1061495) /gene="yhfT" /locus_tag="BSU_10360" /old_locus_tag="BSU10360" /EC_number="6.2.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12368242, 28032445, 28414710; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative long-chain fatty-acid-CoA ligase (proofreading for biotin synthesis)" /protein_id="NP_388917.1" /db_xref="EnsemblGenomes-Gn:BSU10360" /db_xref="EnsemblGenomes-Tr:CAB12876" /db_xref="GOA:O07619" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="SubtiList:BG13064" /db_xref="UniProtKB/Swiss-Prot:O07619" /translation="MTITHTYSSTAETSPGRVAIQTESEQITYHDWDRLVSQTANWLR SQPSMPNRVAILLPNSLAFLQLFAGAAAAGCTAIPIDTRWSPAECKERLSISNADLVV TLAFFKNKLTDSQTPVVLLDNCMADISEAAADPLPTIDPEHPFYMGFTSGSTGKPKAF TRSHRSWMESFTCTETDFSISSDDKVLIPGALMSSHFLYGAVSTLFLGGTVCLLKKFS PAKAKEWLCRESISVLYTVPTMTDALARIEGFPDSPVKIISSGADWPAESKKKLAAAW PHLKLYDFYGTSELSFVTFSSPEDSKRKPHSAGRPFHNVRIEIRNAGGERCQPGEIGK IFVKSPMRFSGYVNGSTPDEWMTVDDMGYVDEEGFLYISGRENGMIVYGGLNIFPEEI ERVLLACPEVESAAVVGIPDEYWGEIAVAVILGNANARTLKAWCKQKLASYKIPKKWV FADSLPETSSGKIARSRVKKWLEESVQYK*" /label="yhfT CDS" gene complement(1060056..1061495) /gene="yhfT" /locus_tag="BSU_10360" /old_locus_tag="BSU10360" /label="yhfT gene" CDS complement(1061502..1062062) /gene="bioY" /locus_tag="BSU_10370" /old_locus_tag="BSU10370" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12368242, 15849754, 16850406, 18931129, 23709504; Product type t : transporter" /codon_start=1 /transl_table=11 /product="biotin transporter" /protein_id="NP_388918.1" /db_xref="EnsemblGenomes-Gn:BSU10370" /db_xref="EnsemblGenomes-Tr:CAB12877" /db_xref="GOA:O07620" /db_xref="InterPro:IPR003784" /db_xref="SubtiList:BG13065" /db_xref="UniProtKB/Swiss-Prot:O07620" /translation="MLKLIDMMHIAIFTALMAVLGFMPPLFLSFTPVPITLQTLGVML AGSILRPKSAFLSQLVFLLLVAFGAPLLPGGRGGFGVFFGPSAGFLIAYPLASWLISL AANRLRKVTVLRLFFTHIVFGIIFIYLLGIPVQAFIMHIDLSQAAFMSLAYVPGDLIK AAVSAFLAIKITQALSLSDTMFTKGG*" /label="bioY CDS" gene complement(1061502..1062062) /gene="bioY" /locus_tag="BSU_10370" /old_locus_tag="BSU10370" /label="bioY gene" misc_feature complement(1061512..1061531) /Source="Nicolas_upshift_promotors" /id="U835" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.585414585414585" /psig="0.97902097902098" /xcortree=2231 /SigmaFactorBS="aaaagcggctgtatctgcatttctggcgataaaaatcactca agccttgtctcttTCTGATACGATGTTTACAAAaggaggatgacaatacatgacaatt a" /listShort="yhfT, yhfS, phoE" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1061526) /Source="Nicolas_upshifts" /id="U835" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.585414585414585" /psig="0.97902097902098" /xcortree=2231 /SigmaFactorBS="aaaagcggctgtatctgcatttctggcgataaaaatcactca agccttgtctcttTCTGATACGATGTTTACAAAaggaggatgacaatacatgacaatt a" /listShort="yhfT, yhfS, phoE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1062087..1062106) /Source="Nicolas_upshift_promotors" /id="U836" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig="0.999000999001" /xcortree=2919 /SigmaFactorBS="ttgcgttcattatgtaaacttaaattaaaaatcAGTTGACAt aataattacctgcATTTATTGTATAACCATATTtgattactttttggaggatttcaca t" /listShort="bioY, yhfT, yhfS, phoE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1062101) /Source="Nicolas_upshifts" /id="U836" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig="0.999000999001" /xcortree=2919 /SigmaFactorBS="ttgcgttcattatgtaaacttaaattaaaaatcAGTTGACAt aataattacctgcATTTATTGTATAACCATATTtgattactttttggaggatttcaca t" /listShort="bioY, yhfT, yhfS, phoE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1062121..1062128) /Source="Nicolas_upshift_promotors" /id="U836" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig="0.999000999001" /xcortree=2919 /SigmaFactorBS="ttgcgttcattatgtaaacttaaattaaaaatcAGTTGACAt aataattacctgcATTTATTGTATAACCATATTtgattactttttggaggatttcaca t" /listShort="bioY, yhfT, yhfS, phoE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1062197..1063495) /gene="hemAT" /locus_tag="BSU_10380" /old_locus_tag="BSU10380" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11481493, 12657801, 12962628, 15033535, 16819829, 17003124, 22528495, 22564695" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11481493, 12657801, 12962628, 15033535, 16819829, 17003124, 22528495, 22564695; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="heme-based dioxygen sensor" /protein_id="NP_388919.1" /db_xref="EnsemblGenomes-Gn:BSU10380" /db_xref="EnsemblGenomes-Tr:CAB12878" /db_xref="GOA:O07621" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR009050" /db_xref="PDB:1OR4" /db_xref="PDB:1OR6" /db_xref="SubtiList:BG13066" /db_xref="UniProtKB/Swiss-Prot:O07621" /translation="MLFKKDRKQETAYFSDSNGQQKNRIQLTNKHADVKKQLKMVRLG DAELYVLEQLQPLIQENIVNIVDAFYKNLDHESSLMDIINDHSSVDRLKQTLKRHIQE MFAGVIDDEFIEKRNRIASIHLRIGLLPKWYMGAFQELLLSMIDIYEASITNQQELLK AIKATTKILNLEQQLVLEAFQSEYNQTRDEQEEKKNLLHQKIQETSGSIANLFSETSR SVQELVDKSEGISQASKAGTVTSSTVEEKSIGGKKELEVQQKQMNKIDTSLVQIEKEM VKLDEIAQQIEKIFGIVTGIAEQTNLLSLNASIESARAGEHGKGFAVVANEVRKLSED TKKTVSTVSELVNNTNTQINIVSKHIKDVNELVSESKEKMTQINRLFDEIVHSMKISK EQSGKIDVDLQAFLGGLQEVSRAVSHVAASVDSLVILTEE*" /label="hemAT CDS" gene complement(1062197..1063495) /gene="hemAT" /locus_tag="BSU_10380" /old_locus_tag="BSU10380" /label="hemAT gene" downshifts complement(1062208) /Source="Nicolas_upshifts" /id="D565" /incds=0 /nref=209 /ntot=243 /MaxReadThrough="2.70691" /MaxDrop="6.97357" /score="5.86442746" /energy="-6.9" /TU="NA" /idTUdmin="U837" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1063549..1063567) /Source="Nicolas_upshift_promotors" /id="U837" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2810 /SigmaFactorBS="tttttcaaatatttttcatctgcagCTTCATTcatgtttccc ttgGCCGATAAAAAAGAAAAAGgcttaaaaagccaaaaagtaaaaattatatttttcc c" /listShort="hemAT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1063552) /Source="Nicolas_upshifts" /id="U837" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2810 /SigmaFactorBS="tttttcaaatatttttcatctgcagCTTCATTcatgtttccc ttgGCCGATAAAAAAGAAAAAGgcttaaaaagccaaaaagtaaaaattatatttttcc c" /listShort="hemAT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1063581..1063587) /Source="Nicolas_upshift_promotors" /id="U837" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2810 /SigmaFactorBS="tttttcaaatatttttcatctgcagCTTCATTcatgtttccc ttgGCCGATAAAAAAGAAAAAGgcttaaaaagccaaaaagtaaaaattatatttttcc c" /listShort="hemAT" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1063634..1065163) /gene="yhfW" /locus_tag="BSU_10390" /old_locus_tag="BSU10390" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase with Rieske [2Fe-2S] center" /protein_id="NP_388920.1" /db_xref="EnsemblGenomes-Gn:BSU10390" /db_xref="EnsemblGenomes-Tr:CAB12879" /db_xref="GOA:O07622" /db_xref="InterPro:IPR005805" /db_xref="InterPro:IPR006076" /db_xref="InterPro:IPR017941" /db_xref="InterPro:IPR036188" /db_xref="InterPro:IPR036922" /db_xref="SubtiList:BG13067" /db_xref="UniProtKB/Swiss-Prot:O07622" /translation="MANQHFAKEAPETYWKTSTDLPSFPALQEDTECDVTIIGGGITG ITTAYELTKRGFRVVLIEANQVLNGTTAHTTAKVTAQHDMIYDEFIRHFGLNHARLYY EANQNAIDYIKGIVDEHQIDCEWIEQDAYLYTANENAVQKIHTEHEAYTKLGIERDLI KDLPIPLGSKLALVMKNQAQFHPLQYLKALLEQIVQKGGRIYEETVALDIKKGERPEV VTKSRHAIKSRFIICCSHFPFYDGGGLYAARMYSDRSYVLAIKPKIEYPEGMYLSIDQ PSVALRYTVVNGEKLILFSGVSHKTGQGKAMSTHYETLRQLAESTIGIESIPYYWSTQ DLVTIDKIPFIGPMSENEDNILVATGFKKWGMTSSAVAATLLSDLVEKKENPYESIFT PSRFHLNPGLQKVISYNADVAKHLIKGKLEKPDVQFEDISPGEGKAVTINGRRAGAFR DETGCLHLVDTTCTHLGCEVEWNDSEHTWDCPCHGSRFKPSGEVVEGPAIKPLKQIDL D*" /label="yhfW CDS" gene complement(1063634..1065163) /gene="yhfW" /locus_tag="BSU_10390" /old_locus_tag="BSU10390" /label="yhfW gene" promotor_-10 complement(1065190..1065208) /Source="Nicolas_upshift_promotors" /id="U838" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.84015984015984" /psig="0.84015984015984" /xcortree=1075 /SigmaFactorBS="ttcaaccttattatgttatgaacaatgcctgcTTCCTAtgta tgaaaagataGAATATGGAAAAATTAAGAataaatctgattggaggtataacggcttg g" /listShort="yhfW, hemAT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1065200) /Source="Nicolas_upshifts" /id="U838" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.84015984015984" /psig="0.84015984015984" /xcortree=1075 /SigmaFactorBS="ttcaaccttattatgttatgaacaatgcctgcTTCCTAtgta tgaaaagataGAATATGGAAAAATTAAGAataaatctgattggaggtataacggcttg g" /listShort="yhfW, hemAT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1065219..1065224 /Source="Nicolas_upshift_promotors" /id="U839" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1100 /SigmaFactorBS="ccaatcagatttattcttaatttttccatattctatcttttc aTACATAggaagcaggcattgtTCATAACATAATAAGGTTGaaaaggagtgatttcat t" /listShort="yhxC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(1065223..1065228) /Source="Nicolas_upshift_promotors" /id="U838" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.84015984015984" /psig="0.84015984015984" /xcortree=1075 /SigmaFactorBS="ttcaaccttattatgttatgaacaatgcctgcTTCCTAtgta tgaaaagataGAATATGGAAAAATTAAGAataaatctgattggaggtataacggcttg g" /listShort="yhfW, hemAT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1065236 /Source="Nicolas_upshifts" /id="U839" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1100 /SigmaFactorBS="ccaatcagatttattcttaatttttccatattctatcttttc aTACATAggaagcaggcattgtTCATAACATAATAAGGTTGaaaaggagtgatttcat t" /listShort="yhxC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1065240..1065258 /Source="Nicolas_upshift_promotors" /id="U839" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1100 /SigmaFactorBS="ccaatcagatttattcttaatttttccatattctatcttttc aTACATAggaagcaggcattgtTCATAACATAATAAGGTTGaaaaggagtgatttcat t" /listShort="yhxC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1065275..1066132 /gene="yhxC" /locus_tag="BSU_10400" /old_locus_tag="BSU10400" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 18643936, 25720121; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388921.1" /db_xref="EnsemblGenomes-Gn:BSU10400" /db_xref="EnsemblGenomes-Tr:CAB12880" /db_xref="GOA:P40397" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11058" /db_xref="UniProtKB/Swiss-Prot:P40397" /translation="MANQKKKTLPPQHQNQQPGFEYLMDPRPVFDKPKKAKKLEGKTA IITGGDSGIGRAVSVLFAKEGANVVIVYLNEHQDAEETKQYVEKEGVKCLLIAGDVGD EAFCNDVVGQASQVFPSIDILVNNAAEQHVQPSIEKITSHQLIRTFQTNIFSMFYLTK AVLPHLKKGSSIINTASITAYKGNKTLIDYSATKGAIVTFTRSLSQSLVQQGIRVNAV APGPIWTPLIPASFAAKDVEVFGSDVPMERPGQPVEVAPSYLYLASDDSTYVTGQTIH VNGGTIVNG*" /label="yhxC CDS" gene 1065275..1066132 /gene="yhxC" /locus_tag="BSU_10400" /old_locus_tag="BSU10400" /label="yhxC gene" downshifts 1066114 /Source="Nicolas_upshifts" /id="D566" /incds=0 /nref=10 /ntot=36 /MaxReadThrough="2.65833" /MaxDrop="4.80135" /score="-8.69335909" /energy="-4.5" /TU="NA" /idTUdmin="U839" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1066160..1066393) /gene="yhzC" /locus_tag="BSU_10410" /old_locus_tag="BSU10410" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388922.1" /db_xref="EnsemblGenomes-Gn:BSU10410" /db_xref="EnsemblGenomes-Tr:CAB12881" /db_xref="InterPro:IPR014957" /db_xref="SubtiList:BG13087" /db_xref="UniProtKB/Swiss-Prot:O31594" /translation="MKEKKSYTELMKSRNTQKTKEFDVTMTDIYIQMVLDESLYNRRL AMLTDQINKALDEKDKDAFLTLSKEYAALKQSE*" /label="yhzC CDS" gene complement(1066160..1066393) /gene="yhzC" /locus_tag="BSU_10410" /old_locus_tag="BSU10410" /label="yhzC gene" downshifts complement(1066193) /Source="Nicolas_upshifts" /id="D567" /incds=0 /nref=191 /ntot=247 /MaxReadThrough="3.34616" /MaxDrop="7.00218" /score="21.4902337" /energy="-12.3" /TU="U841" /idTUdmin="U844" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1066410..1066429) /Source="Nicolas_upshift_promotors" /id="U841" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.914085914085914" /psig="0.999000999001" /xcortree=2872 /SigmaFactorBS="atagattgccaagtattagttgtctaaaaattataaaaattT ATTGATTttttcgaccgttatCCATATACTATAAAAAAGGCattggggggattcttta t" /listShort="yhzC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 1066413..1066414 /Source="Nicolas_upshift_promotors" /id="U840" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.422577422577423" /psig="0.422577422577423" /xcortree=1052 /SigmaFactorBS="cgggacttcatgagctcagtgtacgattttttctctttcata aagaatccccccaatgccTTttTTATAGTATATGGATAacggtcgaaaaaatcaataa a" /listShort="comK" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1066413 /Source="Nicolas_upshifts" /id="U840" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.422577422577423" /psig="0.422577422577423" /xcortree=1052 /SigmaFactorBS="cgggacttcatgagctcagtgtacgattttttctctttcata aagaatccccccaatgccTTttTTATAGTATATGGATAacggtcgaaaaaatcaataa a" /listShort="comK" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1066417..1066432 /Source="Nicolas_upshift_promotors" /id="U840" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.422577422577423" /psig="0.422577422577423" /xcortree=1052 /SigmaFactorBS="cgggacttcatgagctcagtgtacgattttttctctttcata aagaatccccccaatgccTTttTTATAGTATATGGATAacggtcgaaaaaatcaataa a" /listShort="comK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1066432) /Source="Nicolas_upshifts" /id="U841" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.914085914085914" /psig="0.999000999001" /xcortree=2872 /SigmaFactorBS="atagattgccaagtattagttgtctaaaaattataaaaattT ATTGATTttttcgaccgttatCCATATACTATAAAAAAGGCattggggggattcttta t" /listShort="yhzC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1066434..1067289) /Source="Nicolas_S_feature" /locus_tag="new_1116857_1117712_c" /HighExp="Salt, Etha, C30, Heat, S8, LPhT, Gly, C90, S7, UNK1" /AntisenseName="comK" /AntisenseCor="-5.68778941053006E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S365" promotor_-35 complement(1066444..1066451) /Source="Nicolas_upshift_promotors" /id="U841" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.914085914085914" /psig="0.999000999001" /xcortree=2872 /SigmaFactorBS="atagattgccaagtattagttgtctaaaaattataaaaattT ATTGATTttttcgaccgttatCCATATACTATAAAAAAGGCattggggggattcttta t" /listShort="yhzC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1066616..1066623 /Source="Nicolas_upshift_promotors" /id="U842" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.747252747252747" /psig="0.997002997002997" /xcortree=2958 /SigmaFactorBS="ttaaaagatgattttatcttaaatgttaaaaaaacCTGTCGT TttacaaaaacaGATGATAGATTATTAGTATAaattttgcagaaaaaggatggaggcc a" /listShort="comK, S366, S367" /listLong="yhjA" /label="promotor_-35" promotor_-10 1066635..1066654 /Source="Nicolas_upshift_promotors" /id="U842" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.747252747252747" /psig="0.997002997002997" /xcortree=2958 /SigmaFactorBS="ttaaaagatgattttatcttaaatgttaaaaaaacCTGTCGT TttacaaaaacaGATGATAGATTATTAGTATAaattttgcagaaaaaggatggaggcc a" /listShort="comK, S366, S367" /listLong="yhjA" /label="promotor_-10" upshifts 1066641 /Source="Nicolas_upshifts" /id="U842" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.747252747252747" /psig="0.997002997002997" /xcortree=2958 /SigmaFactorBS="ttaaaagatgattttatcttaaatgttaaaaaaacCTGTCGT TttacaaaaacaGATGATAGATTATTAGTATAaattttgcagaaaaaggatggaggcc a" /listShort="comK, S366, S367" /listLong="yhjA" /label="upshifts" CDS 1066686..1067264 /gene="comK" /locus_tag="BSU_10420" /old_locus_tag="BSU10420" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15743949, 15819619, 16554821, 16907804, 17468244, 26091431, 27501195, 27920766" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15743949, 15819619, 16554821, 16907804, 17468244, 26091431, 27501195, 27920766; Product type r: regulator" /codon_start=1 /transl_table=11 /product="competence transcription factor (CTF)" /protein_id="NP_388923.1" /db_xref="EnsemblGenomes-Gn:BSU10420" /db_xref="EnsemblGenomes-Tr:CAB12882" /db_xref="GOA:P40396" /db_xref="InterPro:IPR010461" /db_xref="SubtiList:BG11059" /db_xref="UniProtKB/Swiss-Prot:P40396" /translation="MSQKTDAPLESYEVNGATIAVLPEEIDGKICSKIIEKDCVFYVN MKPLQIVDRSCRFFGSSYAGRKAGTYEVTKISHKPPIMVDPSNQIFLFPTLSSTRPQC GWISHVHVKEFKATEFDDTEVTFSNGKTMELPISYNSFENQVYRTAWLRTKFQDRIDH RVPKRQEFMLYPKEERTKMIYDFILRELGERY*" /label="comK CDS" gene 1066686..1067264 /gene="comK" /locus_tag="BSU_10420" /old_locus_tag="BSU10420" /label="comK gene" S_feature 1067265..1067410 /Source="Nicolas_S_feature" /locus_tag="new_1117688_1117833" /HighExp="GM 150, C30, T-4.40H, T-3.40H, GM 120, M9-tran, T-2.40H, C90, G/S, T-1.10H" /AntisenseName="yhxD" /AntisenseCor="-0.229484184862048" /AntisenseRegPval="-3.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S366" CDS complement(1067311..1068210) /gene="yhxD" /locus_tag="BSU_10430" /old_locus_tag="BSU10430" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_388924.1" /db_xref="EnsemblGenomes-Gn:BSU10430" /db_xref="EnsemblGenomes-Tr:CAB12883" /db_xref="GOA:P40398" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11060" /db_xref="UniProtKB/Swiss-Prot:P40398" /translation="MSDSNLTNPIKAFFHDEFPEQYQEPPGLQKNMKPVPDCGEKSYK GSGKLTGRKALVTGGDSGIGRAAAIAYAREGADVAINYLPEEQPDAEEVKELIEAEGR KAVLIPGDLSDESFCQDLVKQSHHELGGLDVLALVAGKQQAVENIEDLPTEQIYKTFE VNVFSLYWVVKAALPYLPEGASIITTTSVEGYNPSPMLLDYAATKNAIIGFTVGLGKQ LASKGIRVNSVAPGPIWTPLQISGGQPTENIPKFGQGTPPAPLNRAGQPVELADVYVF LASENSSYVTSQVYGITGGIPTA*" /label="yhxD CDS" gene complement(1067311..1068210) /gene="yhxD" /locus_tag="BSU_10430" /old_locus_tag="BSU10430" /label="yhxD gene" downshifts complement(1067334) /Source="Nicolas_upshifts" /id="D568" /incds=0 /nref=7 /ntot=53 /MaxReadThrough="4.95535" /MaxDrop="4.1467" /score="-2.68458203" /energy="-14.6" /TU="U844" /idTUdmin="U844" /TUdmin="-1144" /isTUend="FALSE" /label="downshifts" promotor_-35 1067397..1067400 /Source="Nicolas_upshift_promotors" /id="U843" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95104895104895" /psig="0.010989010989011" /xcortree=17 /SigmaFactorBS="atgtcacatagcttgaattctctgaagctagaaatacataaa catCGGCcaattccactggctgccCAGCGcgatttaatggagctggcggcgtgccttg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1067412 /Source="Nicolas_upshifts" /id="U843" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95104895104895" /psig="0.010989010989011" /xcortree=17 /SigmaFactorBS="atgtcacatagcttgaattctctgaagctagaaatacataaa catCGGCcaattccactggctgccCAGCGcgatttaatggagctggcggcgtgccttg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1067418..1067422 /Source="Nicolas_upshift_promotors" /id="U843" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95104895104895" /psig="0.010989010989011" /xcortree=17 /SigmaFactorBS="atgtcacatagcttgaattctctgaagctagaaatacataaa catCGGCcaattccactggctgccCAGCGcgatttaatggagctggcggcgtgccttg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 1067456 /Source="Nicolas_upshifts" /id="D569" /incds=1 /nref=1 /ntot=5 /MaxReadThrough="5.45904" /MaxDrop="5.6543" /score="-8.69335909" /energy="-4.5" /TU="U842" /idTUdmin="U843" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 1067501..1068367 /Source="Nicolas_S_feature" /locus_tag="new_1117924_1118790" /HighExp="GM 150, C30, T-4.40H, C90, T-3.40H, T-2.40H, G/S, T-5.40H, M9-tran, nit" /AntisenseName="yhxD" /AntisenseCor="-0.32746434250834699" /AntisenseRegPval="-7.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S367" promotor_-10 complement(1068237..1068255) /Source="Nicolas_upshift_promotors" /id="U844" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=190 /SigmaFactorBS="tgttttctttttccttcactattcaaactgccaaaacaTGTT TTTctgcttatgctcagGGGTACACATACGAATGTAcaccaaacagaaaaggagcgtt g" /listShort="yhxD, S365, yhzC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1068254) /Source="Nicolas_upshifts" /id="U844" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=190 /SigmaFactorBS="tgttttctttttccttcactattcaaactgccaaaacaTGTT TTTctgcttatgctcagGGGTACACATACGAATGTAcaccaaacagaaaaggagcgtt g" /listShort="yhxD, S365, yhzC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1068270..1068276) /Source="Nicolas_upshift_promotors" /id="U844" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=190 /SigmaFactorBS="tgttttctttttccttcactattcaaactgccaaaacaTGTT TTTctgcttatgctcagGGGTACACATACGAATGTAcaccaaacagaaaaggagcgtt g" /listShort="yhxD, S365, yhzC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1068344..1068351 /Source="Nicolas_upshift_promotors" /id="U845" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.866133866133866" /psig=1 /xcortree=2715 /SigmaFactorBS="aaaacaagaaaaaacaaagccttcttccatatttaTCTTGTC AaataagactatatgAATTATGATAAATTCGAGCTataaatcaactaaatattgggtg t" /listShort="yhjA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1068366..1068385 /Source="Nicolas_upshift_promotors" /id="U845" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.866133866133866" /psig=1 /xcortree=2715 /SigmaFactorBS="aaaacaagaaaaaacaaagccttcttccatatttaTCTTGTC AaataagactatatgAATTATGATAAATTCGAGCTataaatcaactaaatattgggtg t" /listShort="yhjA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1068369 /Source="Nicolas_upshifts" /id="U845" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.866133866133866" /psig=1 /xcortree=2715 /SigmaFactorBS="aaaacaagaaaaaacaaagccttcttccatatttaTCTTGTC AaataagactatatgAATTATGATAAATTCGAGCTataaatcaactaaatattgggtg t" /listShort="yhjA" /GFF_Attribute="listLong" /label="upshifts" CDS 1068427..1068696 /gene="yhjA" /locus_tag="BSU_10440" /old_locus_tag="BSU10440" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388925.1" /db_xref="EnsemblGenomes-Gn:BSU10440" /db_xref="EnsemblGenomes-Tr:CAB12884" /db_xref="InterPro:IPR008613" /db_xref="SubtiList:BG13068" /db_xref="UniProtKB/Swiss-Prot:O07555" /translation="MKKAAAVLLSLGLVFGFSYGAGHVAEAKTKVKVYKNCKELNKVY KGGVARTSKVKNKGGKTKYKPYVSKALYDANKNKDRDKDLIACER*" /label="yhjA CDS" gene 1068427..1068696 /gene="yhjA" /locus_tag="BSU_10440" /old_locus_tag="BSU10440" /label="yhjA gene" downshifts 1068688 /Source="Nicolas_upshifts" /id="D570" /incds=0 /nref=230 /ntot=267 /MaxReadThrough="2.67325" /MaxDrop="7.59695" /score="27.4895724" /energy="-11.2" /TU="NA" /idTUdmin="U845" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1068736) /Source="Nicolas_upshifts" /id="D571" /incds=0 /nref=11 /ntot=113 /MaxReadThrough="2.40747" /MaxDrop="4.60953" /score="20.2036192" /energy="-11.2" /TU="NA" /idTUdmin="U846" /TUdmin=6 /isTUend="TRUE" /label="downshifts" CDS complement(1068739..1070208) /gene="yhjB" /locus_tag="BSU_10450" /old_locus_tag="BSU10450" /function="16.1: Circulate" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16267290, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative Na+/metabolite cotransporter" /protein_id="NP_388926.1" /db_xref="EnsemblGenomes-Gn:BSU10450" /db_xref="EnsemblGenomes-Tr:CAB12885" /db_xref="GOA:O07556" /db_xref="InterPro:IPR001734" /db_xref="SubtiList:BG13069" /db_xref="UniProtKB/Swiss-Prot:O07556" /translation="MNAALIIIFGVLLLSIFLGIRAQKGKDMNLEQWTVGGRGFGTVF VFLLMAGEIYTTFTFLGGSGWAYGKGGPAFYIIAYGCLAYILSYWLLPAVWTYAKQHK LMSQSDFFTKKYNSPLLGILVSLVGIAALIPYLVLQLKGLGLIVSETSYGKITPTAAI WIGAVSITVYVMVSGIHGSAWISVVKDIMILVVVLFLGVYLPIHYYGGFQDMFQQIET AKPGFLTLPESGQSVAWFSSTVLLTALGFYMWPHTFSASYSAENPKVFRKNAIIMPLY QLVLLFVLFVGFAAILQVPDLNGADGDLSLLRLSLQAFDPWFVGIIGAAGLLTALVPG SMILMSASTLFAKNVYKVIAPRTTEQQVSALAKFLVPVIALISVYFTFKGGNTIVTLL LMGYSLVTQLFPALLFSLLKHNMVTKQGAFAGIIAGVGAVTYITMTETTIGTLFPALP QAAKDLNVGIVALLLNITVMMAVSLMTRKAKSAAADQAA*" /label="yhjB CDS" gene complement(1068739..1070208) /gene="yhjB" /locus_tag="BSU_10450" /old_locus_tag="BSU10450" /label="yhjB gene" CDS complement(1070205..1070405) /gene="yhjC" /locus_tag="BSU_10460" /old_locus_tag="BSU10460" /function="16.1: Circulate" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16267290; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_388927.1" /db_xref="EnsemblGenomes-Gn:BSU10460" /db_xref="EnsemblGenomes-Tr:CAB12886" /db_xref="GOA:O07557" /db_xref="InterPro:IPR021741" /db_xref="SubtiList:BG13070" /db_xref="UniProtKB/Swiss-Prot:O07557" /translation="MKLIHVLAALPFIGILLGIPFANKVTPYVFGMPFILAYIVMWAL LTSALMAIVYVLDKENKKEEAE*" /label="yhjC CDS" gene complement(1070205..1070405) /gene="yhjC" /locus_tag="BSU_10460" /old_locus_tag="BSU10460" /label="yhjC gene" S_feature complement(1070406..1070524) /Source="Nicolas_S_feature" /locus_tag="new_1120829_1120947_c" /HighExp="S1, Etha, HiOs, MG 120, LoTm, T-5.40H, S2, GM-0.1, GM-0.2, T0.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S368" promotor_-10 complement(1070507..1070526) /Source="Nicolas_upshift_promotors" /id="U846" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.574425574425574" /psig=1 /xcortree=2904 /SigmaFactorBS="cttcgggcgattcagagcattaatttcagacaattcacACTA TACAaacaaaataaatTTATTTATAATTCGAACCACagcctttcactccaaaaaatga c" /listShort="S368, yhjC, yhjB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1070524) /Source="Nicolas_upshifts" /id="U846" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.574425574425574" /psig=1 /xcortree=2904 /SigmaFactorBS="cttcgggcgattcagagcattaatttcagacaattcacACTA TACAaacaaaataaatTTATTTATAATTCGAACCACagcctttcactccaaaaaatga c" /listShort="S368, yhjC, yhjB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1070539..1070546) /Source="Nicolas_upshift_promotors" /id="U846" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.574425574425574" /psig=1 /xcortree=2904 /SigmaFactorBS="cttcgggcgattcagagcattaatttcagacaattcacACTA TACAaacaaaataaatTTATTTATAATTCGAACCACagcctttcactccaaaaaatga c" /listShort="S368, yhjC, yhjB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(1070612) /Source="Nicolas_upshifts" /id="D572" /incds=0 /nref=1 /ntot=8 /MaxReadThrough="3.99656" /MaxDrop="2.67326" /score="20.2036192" /energy="-11.2" /TU="U848" /idTUdmin="U848" /TUdmin="-374" /isTUend="FALSE" /label="downshifts" CDS complement(1070613..1070975) /gene="yhjD" /locus_tag="BSU_10470" /old_locus_tag="BSU10470" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16267290" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388928.1" /db_xref="EnsemblGenomes-Gn:BSU10470" /db_xref="EnsemblGenomes-Tr:CAB12887" /db_xref="GOA:O07558" /db_xref="SubtiList:BG13071" /db_xref="UniProtKB/Swiss-Prot:O07558" /translation="MPNLQEEIYDLIERALFLPMAITIFNRDLAGIEESTLKLKHPYK QLISESLKIAQKDLMEVRKELRKRKIAIRETERDEAFTLYTFVIDGYEENHRYFNPRI REQVSELLTYYLFAPDRL*" /label="yhjD CDS" gene complement(1070613..1070975) /gene="yhjD" /locus_tag="BSU_10470" /old_locus_tag="BSU10470" /label="yhjD gene" promotor_-35 1070813..1070818 /Source="Nicolas_upshift_promotors" /id="U847" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.963036963036963" /psig="0.963036963036963" /xcortree=1144 /SigmaFactorBS="tttcctcagttcttttctgacctccatcaaatccttttGTGC TAtttttaatgattcgcTGATAAGCTGTTTATAAGGatgcttcaattttaatgtgctt t" /listShort="S369, yhjE, sipV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1070834..1070852 /Source="Nicolas_upshift_promotors" /id="U847" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.963036963036963" /psig="0.963036963036963" /xcortree=1144 /SigmaFactorBS="tttcctcagttcttttctgacctccatcaaatccttttGTGC TAtttttaatgattcgcTGATAAGCTGTTTATAAGGatgcttcaattttaatgtgctt t" /listShort="S369, yhjE, sipV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1070835 /Source="Nicolas_upshifts" /id="U847" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.963036963036963" /psig="0.963036963036963" /xcortree=1144 /SigmaFactorBS="tttcctcagttcttttctgacctccatcaaatccttttGTGC TAtttttaatgattcgcTGATAAGCTGTTTATAAGGatgcttcaattttaatgtgctt t" /listShort="S369, yhjE, sipV" /GFF_Attribute="listLong" /label="upshifts" S_feature 1070844..1071083 /Source="Nicolas_S_feature" /locus_tag="new_1121267_1121506" /HighExp="S6, S4, S8, S5, LoTm, B36, S3, S7, BT, B60" /AntisenseName="yhjD" /AntisenseCor="0.24202608585419999" /AntisenseRegPval="-4.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.963" /TUlongSig="NA" /TUlongPSig="NA" /label="S369" promotor_-10 complement(1071005..1071024) /Source="Nicolas_upshift_promotors" /id="U848" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.975024975024975" /psig="0.999000999001" /xcortree=1502 /SigmaFactorBS="tcagcagaaaactaaaaagttttggtgattttttctgTCTTG AAAcatttcaccagccgATATAGAATACAAATAGAACaaacgttcccttagaaagaag g" /listShort="yhjD, S368, yhjC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1071023) /Source="Nicolas_upshifts" /id="U848" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.975024975024975" /psig="0.999000999001" /xcortree=1502 /SigmaFactorBS="tcagcagaaaactaaaaagttttggtgattttttctgTCTTG AAAcatttcaccagccgATATAGAATACAAATAGAACaaacgttcccttagaaagaag g" /listShort="yhjD, S368, yhjC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1071039..1071046) /Source="Nicolas_upshift_promotors" /id="U848" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.975024975024975" /psig="0.999000999001" /xcortree=1502 /SigmaFactorBS="tcagcagaaaactaaaaagttttggtgattttttctgTCTTG AAAcatttcaccagccgATATAGAATACAAATAGAACaaacgttcccttagaaagaag g" /listShort="yhjD, S368, yhjC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1071065..1071072 /Source="Nicolas_upshift_promotors" /id="U849" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.711288711288711" /psig="0.998001998001998" /xcortree=619 /SigmaFactorBS="cggctggtgaaatgtttcaagacagaaaaaatcaccaaaaCT TTTTAGttttctgctgataATGTGTAGAATAAGGATAGAcaaacccggtaaggagtat a" /listShort="yhjE, sipV" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1071085 /Source="Nicolas_upshifts" /id="U849" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.711288711288711" /psig="0.998001998001998" /xcortree=619 /SigmaFactorBS="cggctggtgaaatgtttcaagacagaaaaaatcaccaaaaCT TTTTAGttttctgctgataATGTGTAGAATAAGGATAGAcaaacccggtaaggagtat a" /listShort="yhjE, sipV" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1071086..1071105 /Source="Nicolas_upshift_promotors" /id="U849" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.711288711288711" /psig="0.998001998001998" /xcortree=619 /SigmaFactorBS="cggctggtgaaatgtttcaagacagaaaaaatcaccaaaaCT TTTTAGttttctgctgataATGTGTAGAATAAGGATAGAcaaacccggtaaggagtat a" /listShort="yhjE, sipV" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1071127..1071750 /gene="yhjE" /locus_tag="BSU_10480" /old_locus_tag="BSU10480" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_388929.1" /db_xref="EnsemblGenomes-Gn:BSU10480" /db_xref="EnsemblGenomes-Tr:CAB12888" /db_xref="GOA:O07559" /db_xref="InterPro:IPR015414" /db_xref="InterPro:IPR032816" /db_xref="SubtiList:BG13072" /db_xref="UniProtKB/Swiss-Prot:O07559" /translation="MLEHFLSYLTQEHLTELFQSYRAFGPLIAVLLPLIEAFLPFLPL IVFVVANTNSFGLWEGFILSWAGSTAGSILVFLIVRQYGQRKLLGFIRSHPSVRKLML WVERHGFGPMFLLLCFPFTPSAAVNVVAGLSRIGTRPFILAAASGKLVMIFMISFIGY DLHALITQPIRTVIAVLVITVLWYVGKKVERYLHVRASQREHDGGRQ*" /label="yhjE CDS" gene 1071127..1071750 /gene="yhjE" /locus_tag="BSU_10480" /old_locus_tag="BSU10480" /label="yhjE gene" CDS 1071752..1072258 /gene="sipV" /locus_tag="BSU_10490" /old_locus_tag="BSU10490" /EC_number="3.4.21.89" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9325333, 9694797, 11309398, 12897006, 14568161, 27159567" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9325333, 9694797, 11309398, 12897006, 14568161, 27159567; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="type I signal peptidase" /protein_id="NP_388930.1" /db_xref="EnsemblGenomes-Gn:BSU10490" /db_xref="EnsemblGenomes-Tr:CAB12889" /db_xref="GOA:O07560" /db_xref="InterPro:IPR000223" /db_xref="InterPro:IPR015927" /db_xref="InterPro:IPR019756" /db_xref="InterPro:IPR019757" /db_xref="InterPro:IPR019758" /db_xref="InterPro:IPR036286" /db_xref="SubtiList:BG12674" /db_xref="UniProtKB/Swiss-Prot:O07560" /translation="MKKRFWFLAGVVSVVLAIQVKNAVFIDYKVEGVSMNPTFQEGNE LLVNKFSHRFKTIHRFDIVLFKGPDHKVLIKRVIGLPGETIKYKDDQLYVNGKQVAEP FLKHLKSVSAGSHVTGDFSLKDVTGTSKVPKGKYFVVGDNRIYSFDSRHFGPIREKNI VGVISDAE*" /label="sipV CDS" gene 1071752..1072258 /gene="sipV" /locus_tag="BSU_10490" /old_locus_tag="BSU10490" /label="sipV gene" downshifts 1072251 /Source="Nicolas_upshifts" /id="D573" /incds=0 /nref=131 /ntot=250 /MaxReadThrough="0.63331" /MaxDrop="4.58282" /score="-7.37718733" /energy="-7.1" /TU="NA" /idTUdmin="U847" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1072309..1072316 /Source="Nicolas_upshift_promotors" /id="U850" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.662337662337662" /psig=1 /xcortree=2713 /SigmaFactorBS="cgtctttttgtatgccgtttggaaaaatgtGTTGAAGAaaaa tttgtaaggAGCTATAATCAAAATTGTTAcctgtgtaacaaaatttatatattttttt g" /listShort="S370, yhjG, yhjH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1072330..1072349 /Source="Nicolas_upshift_promotors" /id="U850" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.662337662337662" /psig=1 /xcortree=2713 /SigmaFactorBS="cgtctttttgtatgccgtttggaaaaatgtGTTGAAGAaaaa tttgtaaggAGCTATAATCAAAATTGTTAcctgtgtaacaaaatttatatattttttt g" /listShort="S370, yhjG, yhjH" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1072339..1072438 /Source="Nicolas_S_feature" /locus_tag="new_1122762_1122861" /HighExp="LBGstat, LBGexp, Lbtran, C90, dia0, Lbexp, HPh, dia5, aero, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S370" upshifts 1072339 /Source="Nicolas_upshifts" /id="U850" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.662337662337662" /psig=1 /xcortree=2713 /SigmaFactorBS="cgtctttttgtatgccgtttggaaaaatgtGTTGAAGAaaaa tttgtaaggAGCTATAATCAAAATTGTTAcctgtgtaacaaaatttatatattttttt g" /listShort="S370, yhjG, yhjH" /GFF_Attribute="listLong" /label="upshifts" CDS 1072439..1073938 /gene="yhjG" /locus_tag="BSU_10500" /old_locus_tag="BSU10500" /EC_number="1.14.13.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7678243, 15121720; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aromatic compound monooxygenase/hydroxylase" /protein_id="NP_388931.1" /db_xref="EnsemblGenomes-Gn:BSU10500" /db_xref="EnsemblGenomes-Tr:CAB12890" /db_xref="GOA:O07561" /db_xref="InterPro:IPR002938" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG13073" /db_xref="UniProtKB/Swiss-Prot:O07561" /translation="MMMKYEAVIIGGGPVGFMLASELAIAGVGTCVIERLEKPVPHSK ALTLHPRTLELLEMRGILERFVSKGSKIPTGHFSMLDTRLDFSGLDTSCPYTLLLPQS KTEKLLEDHARSLGTEVFRGAEALAVTQNGEAVQTIFKDRDGSVRTITSKFAVGADGA GSTVRKQAKIEFPGTDSTVTAALGDVVLLSPPPSGVLSLCTKEGGVMIVPLSPDRYRV VVISPYRTQTPKDVPVTEEELKADLLRICGTDFGLTDPSWMSRFGNAARQAKRYRDGR IFLAGDAAHIHFPAGGQGLNVGLQDAMNLGWKLAAAIKGSAPSWLLDSYHDERHPAAE GLLRNTEAQTKLIDFTQAGLHLRSMMSELLAFPDVNRYVAGQISALDVRYEADRTMPP NRLNGARLPDMKLILSDGNSERLYSFLQNGTFVLLSLRQEADDHIEVKGLRTVTASLA EPNEKLRNVHTILIRPDGHVAWAVDASAPDCSEVIQKGISRWFSVTSRV*" /label="yhjG CDS" gene 1072439..1073938 /gene="yhjG" /locus_tag="BSU_10500" /old_locus_tag="BSU10500" /label="yhjG gene" promotor_-35 1073946..1073953 /Source="Nicolas_upshift_promotors" /id="U851" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig=1 /xcortree=1955 /SigmaFactorBS="cagccgctggttttccgtcaccagccgagtataattcaattC GATTGTTtcatctgtaacaaAACGGTATGATAGAAGAAACaatcgaatgaaaaaggat g" /listShort="yhjH" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1073965 /Source="Nicolas_upshifts" /id="U851" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig=1 /xcortree=1955 /SigmaFactorBS="cagccgctggttttccgtcaccagccgagtataattcaattC GATTGTTtcatctgtaacaaAACGGTATGATAGAAGAAACaatcgaatgaaaaaggat g" /listShort="yhjH" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1073967..1073986 /Source="Nicolas_upshift_promotors" /id="U851" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig=1 /xcortree=1955 /SigmaFactorBS="cagccgctggttttccgtcaccagccgagtataattcaattC GATTGTTtcatctgtaacaaAACGGTATGATAGAAGAAACaatcgaatgaaaaaggat g" /listShort="yhjH" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1074015..1074542 /gene="yhjH" /locus_tag="BSU_10510" /old_locus_tag="BSU10510" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_388932.1" /db_xref="EnsemblGenomes-Gn:BSU10510" /db_xref="EnsemblGenomes-Tr:CAB12891" /db_xref="GOA:Q796S4" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13074" /db_xref="UniProtKB/Swiss-Prot:Q796S4" /translation="MNTDHTKRNLFELYAELIHQQEKWEGLIKAFLSDELRKLDVEHG SKSQLTMTEIHVLSCVGDNEPINVTSIAEKMNTTKATVSRISTKLLGAGFLHRTQLSD NKKEVYFRLTPAGKKLHSLHKYYHQKAEQRFLSFFDRYTEEEILFAERLFRDLVTKWY PSSEEIEGGLPSIFK*" /label="yhjH CDS" gene 1074015..1074542 /gene="yhjH" /locus_tag="BSU_10510" /old_locus_tag="BSU10510" /label="yhjH gene" downshifts 1074504 /Source="Nicolas_upshifts" /id="D574" /incds=0 /nref=8 /ntot=128 /MaxReadThrough="1.1509" /MaxDrop="3.41655" /score="11.3050978" /energy="-9.9" /TU="NA" /idTUdmin="U851" /TUdmin=8 /isTUend="TRUE" /label="downshifts" S_feature complement(1074556..1074699) /Source="Nicolas_S_feature" /locus_tag="new_1124979_1125122_c" /HighExp="B36, B60, T0.30H, LBGstat, T1.30H, T1.0H, LPhT, LBGtran, Diami, T-0.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.979" /TUlongSig="NA" /TUlongPSig="NA" /label="S371" downshifts complement(1074594) /Source="Nicolas_upshifts" /id="D575" /incds=0 /nref=4 /ntot=72 /MaxReadThrough="1.20458" /MaxDrop="5.06167" /score="27.254423" /energy="-9.9" /TU="NA" /idTUdmin="U855" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1074700..1075905) /gene="glcP" /locus_tag="BSU_10520" /old_locus_tag="BSU10520" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9457850, 15849754, 16850406, 17056753, 19087206" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9457850, 15849754, 16850406, 17056753, 19087206; Product type t : transporter" /codon_start=1 /transl_table=11 /product="glucose/mannose:H+ symporter (recent HGT island)" /protein_id="NP_388933.1" /db_xref="EnsemblGenomes-Gn:BSU10520" /db_xref="EnsemblGenomes-Tr:CAB12892" /db_xref="GOA:O07563" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13075" /db_xref="UniProtKB/Swiss-Prot:O07563" /translation="MLRGTYLFGYAFFFTVGIIHISTGSLTPFLLEAFNKTTDDISVI IFFQFTGFLSGVLIAPLMIKKYSHFRTLTLALTIMLVALSIFFLTKDWYYIIVMAFLL GYGAGTLETTVGSFVIANFESNAEKMSKLEVLFGLGALSFPLLINSFIDINNWFLPYY CIFTFLFVLFVGWLIFLSKNREYAKNANQQVTFPDGGAFQYFIGDRKKSKQLGFFVFF AFLYAGIETNFANFLPSIMINQDNEQISLISVSFFWVGIIIGRILIGFVSRRLDFSKY LLFSCSCLIVLLIAFSYISNPILQLSGTFLIGLSIAGIFPIALTLASIIIQKYVDEVT SLFIASASFGGAIISFLIGWSLNQDTILLTMGIFTTMAVILVGISVKIRRTKTEDPIS LENKASKTQ*" /label="glcP CDS" gene complement(1074700..1075905) /gene="glcP" /locus_tag="BSU_10520" /old_locus_tag="BSU10520" /label="glcP gene" promotor_-35 1075395..1075400 /Source="Nicolas_upshift_promotors" /id="U852" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1194 /SigmaFactorBS="tctcggttcttagacaagaaaattaaccaccctaCGAATAgg acgaataaaaaggtGAATATACAGTAATATGGTaaaaaccagttattgatatctatga a" /listShort="S372" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1075417..1075435 /Source="Nicolas_upshift_promotors" /id="U852" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1194 /SigmaFactorBS="tctcggttcttagacaagaaaattaaccaccctaCGAATAgg acgaataaaaaggtGAATATACAGTAATATGGTaaaaaccagttattgatatctatga a" /listShort="S372" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1075420..1075946 /Source="Nicolas_S_feature" /locus_tag="new_1125843_1126369" /HighExp="S4, S5, S6, S8, S7, S3, T5.0H, M9-stat, LBGstat, T4.0H" /AntisenseName="glcP" /AntisenseCor="-0.155079396671681" /AntisenseRegPval="-2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S372" upshifts 1075421 /Source="Nicolas_upshifts" /id="U852" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1194 /SigmaFactorBS="tctcggttcttagacaagaaaattaaccaccctaCGAATAgg acgaataaaaaggtGAATATACAGTAATATGGTaaaaaccagttattgatatctatga a" /listShort="S372" /GFF_Attribute="listLong" /label="upshifts" downshifts 1075904 /Source="Nicolas_upshifts" /id="D576" /incds=0 /nref=6 /ntot=59 /MaxReadThrough="2.40974" /MaxDrop="3.26024" /score="9.68585629" /energy="-9.4" /TU="NA" /idTUdmin="U852" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1075977..1077029) /gene="ntdC" /locus_tag="BSU_10530" /old_locus_tag="BSU10530" /EC_number="1.1.1.-" /function="16.8: Protect" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14612444, 17056753, 23586652, 28353336" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14612444, 17056753, 23586652, 28353336; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="biosynthesis of neotrehalosadiamine (3,3'-diamino-3,3'-dideoxy-alpha,beta-trehalose), glucose-6-P 3-dehydrogenase; kanosamine biosynthesis (recent HGT island)" /protein_id="NP_388934.2" /db_xref="EnsemblGenomes-Gn:BSU10530" /db_xref="EnsemblGenomes-Tr:CAB12893" /db_xref="GOA:O07564" /db_xref="InterPro:IPR000683" /db_xref="InterPro:IPR004104" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13076" /db_xref="UniProtKB/Swiss-Prot:O07564" /translation="MKKIGIIGAGGIARAHATALSTIKNAELVGVYDINQQNAESFVK TFGGKSFENVDELIDASEGLIVASPNFCHKEHALQALGKHKHVLCEKPMAISLEEASI MKDTAERLSVRASMGFNYRYLSYVNILKSLIINNELGNILSIKVHFKKNSALRRKKFT WRDDANSKKTSGSLGDLGIHLIDMVWYLFESDFITESVRAKMNTNVKTKEDKQVLVDD YAEIYGQLKNKVFVNIITSKCSVPEDCGFSIEVVGHKKEFKYHTGNPHVYKLIDGLNV VDCPVPQSLLNDPPNEFYGWADSFRSELINWIASTQNDWVEIPSFSDGFRSQEVLEMF FEKDSNSQPMSVSAVN*" /label="ntdC CDS" gene complement(1075977..1077029) /gene="ntdC" /locus_tag="BSU_10530" /old_locus_tag="BSU10530" /label="ntdC gene" CDS complement(1077043..1077891) /gene="ntdB" /locus_tag="BSU_10540" /old_locus_tag="BSU10540" /EC_number="3.-.-.-" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14612444, 17056753, 23586652" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14612444, 17056753, 23586652; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="biosynthesis of neotrehalosadiamine (3,3'-diamino-3,3'-dideoxy-alpha, beta-trehalose);kanosamine-6-phosphate phosphatase (recent HGT island)" /protein_id="NP_388935.2" /db_xref="EnsemblGenomes-Gn:BSU10540" /db_xref="EnsemblGenomes-Tr:CAB12894" /db_xref="GOA:O07565" /db_xref="InterPro:IPR006379" /db_xref="InterPro:IPR006380" /db_xref="InterPro:IPR036412" /db_xref="PDB:3GYG" /db_xref="SubtiList:BG13077" /db_xref="UniProtKB/Swiss-Prot:O07565" /translation="MLLSKKSEYKTLSTVEHPQYIVFCDFDETYFPHTIDEQKQQDIY ELEDYLEQKSKDGELIIGWVTGSSIESILDKMGRGKFRYFPHFIASDLGTEITYFSEH NFGQQDNKWNSRINEGFSKEKVEKLVKQLHENHNILLNPQTQLGKSRYKHNFYYQEQD EINDKKNLLAIEKICEEYGVSVNINRCNPLAGDPEDSYDVDFIPIGTGKNEIVTFMLE KYNLNTERAIAFGDSGNDVRMLQTVGNGYLLKNATQEAKNLHNLITDSEYSKGITNTL KKLIGS*" /label="ntdB CDS" gene complement(1077043..1077891) /gene="ntdB" /locus_tag="BSU_10540" /old_locus_tag="BSU10540" /label="ntdB gene" CDS complement(1077863..1079188) /gene="ntdA" /locus_tag="BSU_10550" /old_locus_tag="BSU10550" /EC_number="2.6.1.-" /function="16.5: Explore" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:14612444, 17056753, 19087206, 23586652, 24097983, 24509311, 28353336" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14612444, 17056753, 19087206, 23586652, 24097983, 24509311, 28353336; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="biosynthesis of neotrehalosadiamine (3,3'-diamino-3,3'-dideoxy-alpha, beta-trehalose);3-oxo-glucose-6-phosphate:glutamate aminotransferase; kanosamine aminotransferase (recent HGT island)" /protein_id="NP_388936.1" /db_xref="EnsemblGenomes-Gn:BSU10550" /db_xref="EnsemblGenomes-Tr:CAB12895" /db_xref="GOA:O07566" /db_xref="InterPro:IPR000653" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="PDB:4K2B" /db_xref="PDB:4K2I" /db_xref="PDB:4K2M" /db_xref="SubtiList:BG13078" /db_xref="UniProtKB/Swiss-Prot:O07566" /translation="MQKQVKISGKSKENMSLLKHLKGDVQGKELVIEDSIVNERWKQV LKEKIDIEHDLFNYQKNREISKVPFLPVDRLITNDEVEDILNTLTEVLPTGKFTSGPY LEQFEKVLSTYLHKRYVIATSSGTDAIMIGLLALGLNPGDEVIMPANSFSATENAVLA SGGVPIYVDINPQTFCIDPDKIEEAITPYTKFILPVHLYGKHSDMQHIRQIANRYKLK VIEDACQGIGLTDLGKYADITTLSFNPYKNFGVCGKAGAIATDNEELAKKCIQFSYHG FEVNVKNKKVINFGFNSKMDNLQAAIGLERMKYLSLNNFKRLFLADRYITQLAELQNK GYIELPELSEDHVWHLFPIKVRTEDRADIMTKLNEDFGVQTDVYYPILSHMQKTPLVQ DKYAGLQLVHTEKAHSQVLHLPLYPSFTLEEQDRVMEGLFHVIKQEIGV*" /label="ntdA CDS" gene complement(1077863..1079188) /gene="ntdA" /locus_tag="BSU_10550" /old_locus_tag="BSU10550" /label="ntdA gene" promotor_-35 1078032..1078037 /Source="Nicolas_upshift_promotors" /id="U853" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1031 /SigmaFactorBS="cctgcatacttgtcctgtactaaaggagtttttTGCATAtga gaaagtattggaTAATATACATCTGTTTGAAcaccaaaatcttcatttaatttagtca t" /listShort="S373, S374, yhjM" /listLong="S375" /label="promotor_-35" promotor_-10 1078053..1078071 /Source="Nicolas_upshift_promotors" /id="U853" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1031 /SigmaFactorBS="cctgcatacttgtcctgtactaaaggagtttttTGCATAtga gaaagtattggaTAATATACATCTGTTTGAAcaccaaaatcttcatttaatttagtca t" /listShort="S373, S374, yhjM" /listLong="S375" /label="promotor_-10" S_feature 1078059..1078847 /Source="Nicolas_S_feature" /locus_tag="new_1128482_1129270" /HighExp="S4, S3, S5, S6, S7, T5.0H, M9-stat, S8, Pyr, G/S" /AntisenseName="ntdA" /AntisenseCor="-0.29559566742128002" /AntisenseRegPval="-6.1" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S373" upshifts 1078059 /Source="Nicolas_upshifts" /id="U853" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1031 /SigmaFactorBS="cctgcatacttgtcctgtactaaaggagtttttTGCATAtga gaaagtattggaTAATATACATCTGTTTGAAcaccaaaatcttcatttaatttagtca t" /listShort="S373, S374, yhjM" /listLong="S375" /label="upshifts" promotor_-35 1078823..1078830 /Source="Nicolas_upshift_promotors" /id="U854" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.776223776223776" /psig="0.998001998001998" /xcortree=2928 /SigmaFactorBS="ataaacctatcataatagcatcggttccactgctGGTTGCAA ttacataccttttaTGTAAATATGTAGATAAAACtttttcgaattgctctaaataggg a" /listShort="S374, yhjM, S375" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1078845..1078864 /Source="Nicolas_upshift_promotors" /id="U854" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.776223776223776" /psig="0.998001998001998" /xcortree=2928 /SigmaFactorBS="ataaacctatcataatagcatcggttccactgctGGTTGCAA ttacataccttttaTGTAAATATGTAGATAAAACtttttcgaattgctctaaataggg a" /listShort="S374, yhjM, S375" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1078849..1079291 /Source="Nicolas_S_feature" /locus_tag="new_1129272_1129714" /HighExp="T4.0H, T3.0H, T2.30H, HiOs, T3.30H, T2.0H, T5.0H, T1.30H, LoTm, T-1.10H" /AntisenseName="ntdA" /AntisenseCor="-0.101471720232752" /AntisenseRegPval="-1" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="0.998, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S374" upshifts 1078849 /Source="Nicolas_upshifts" /id="U854" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.776223776223776" /psig="0.998001998001998" /xcortree=2928 /SigmaFactorBS="ataaacctatcataatagcatcggttccactgctGGTTGCAA ttacataccttttaTGTAAATATGTAGATAAAACtttttcgaattgctctaaataggg a" /listShort="S374, yhjM, S375" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1079223..1079242) /Source="Nicolas_upshift_promotors" /id="U855" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.849150849150849" /psig="0.97902097902098" /xcortree=1578 /SigmaFactorBS="gcatattttcccttccttaaaaaagttgttgaCATGTTACcg atttcagaaacTAGGATAAATTTGTAATAAAtttttagattataaaatcattggaggt a" /listShort="ntdA, ntdB, ntdC, glcP, S371" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1079235) /Source="Nicolas_upshifts" /id="U855" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.849150849150849" /psig="0.97902097902098" /xcortree=1578 /SigmaFactorBS="gcatattttcccttccttaaaaaagttgttgaCATGTTACcg atttcagaaacTAGGATAAATTTGTAATAAAtttttagattataaaatcattggaggt a" /listShort="ntdA, ntdB, ntdC, glcP, S371" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1079256..1079263) /Source="Nicolas_upshift_promotors" /id="U855" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.849150849150849" /psig="0.97902097902098" /xcortree=1578 /SigmaFactorBS="gcatattttcccttccttaaaaaagttgttgaCATGTTACcg atttcagaaacTAGGATAAATTTGTAATAAAtttttagattataaaatcattggaggt a" /listShort="ntdA, ntdB, ntdC, glcP, S371" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1079292..1080281 /gene="ntdR" /locus_tag="BSU_10560" /old_locus_tag="BSU10560" /experiment="publication(s) with functional evidences, PMID:14612444, 17056753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14612444, 17056753; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of the ntd operon (NtdR-NTD) (recent HGT island)" /protein_id="NP_388937.1" /db_xref="EnsemblGenomes-Gn:BSU10560" /db_xref="EnsemblGenomes-Tr:CAB12896" /db_xref="GOA:O07567" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG13079" /db_xref="UniProtKB/Swiss-Prot:O07567" /translation="MPTIDEIAKLCNVSKTTVSRVLNNHPYVSKEKRDMILKAINELD YTPNYLARNFRRNKTQTIALSVPSIDHPFFAQLIKGVSHEVLFKNYKVIVFQTFYDKQ TELELLELLKHKEVDGIILGTLENEWDQISPFLKYGPILLCNEYHHSADITIIGYDEF EAAYMGVVHLIERGHKKIGFCFDTPYSEAQCQRKEGYLKALQDYNLHHRSEWIFGEMF NIEDGFRVFHKIKDLKDRPSAIFTGNDQVAAGIIKQAMKNGFKVPEDLAVIGFDNQLI CQVVTPTITTIDIPVIELGQQAVLKIIESISGNASLNRRIIKLPTKLIIREST*" /label="ntdR CDS" gene 1079292..1080281 /gene="ntdR" /locus_tag="BSU_10560" /old_locus_tag="BSU10560" /label="ntdR gene" S_feature 1080282..1080659 /Source="Nicolas_S_feature" /locus_tag="new_1130705_1131082" /HighExp="T4.0H, T5.0H, T3.30H, T2.0H, HiOs, T2.30H, T3.0H, LoTm, T1.30H, Pyr" /AntisenseName="yhjN" /AntisenseCor="-5.0383887616073E-2" /AntisenseRegPval="-0.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="SigEF" /TUlongPSig="0.997" /label="S375" S_feature complement(1080336..1080494) /Source="Nicolas_S_feature" /locus_tag="new_1130759_1130917_c" /HighExp="B60, Sw, Cold, B36, BI, GM 15, GM 10, C30, GM 25, GM 60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S376" downshifts complement(1080379) /Source="Nicolas_upshifts" /id="D577" /incds=0 /nref=25 /ntot=169 /MaxReadThrough="3.07371" /MaxDrop="4.24831" /score="-1.9470655" /energy="-7.1" /TU="U856" /idTUdmin="U856" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" CDS complement(1080495..1081649) /gene="yhjN" /locus_tag="BSU_10570" /old_locus_tag="BSU10570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein (recentHGT island)" /protein_id="NP_388938.1" /db_xref="EnsemblGenomes-Gn:BSU10570" /db_xref="EnsemblGenomes-Tr:CAB12897" /db_xref="GOA:O07568" /db_xref="InterPro:IPR007820" /db_xref="InterPro:IPR017516" /db_xref="SubtiList:BG13080" /db_xref="UniProtKB/Swiss-Prot:O07568" /translation="MKKDENLLKDLWFIAISAAGGFILSLTGISIGWMIGTLIVACCL AMIRPAWLMMAPDQKGINRRWLALGQMILGIELGQKLNLSVLSVLKDHWFSVGVMLIL SILLAMLSGYVLWRFSKTDMMTSFVGTAPGGLSAMPSIAQEVGANTAIVSLVQMMRVL LVVLSIPFLVILIYTKQDRTASAAAETISSATTDFRLAPVLWTVILILAAWGACKAAK FLKFPAPWLLGSMLGVAIVHVGGAAVTGHDMTAWWLSQANHVSQVFLGATIGSKMYKS MFAGVTRIIIVGFVSSVGLIAAMFLSAVIVSELTGISLITSVLAFAPGGIAEMATTSV TLHADSTFVVAVQVIRVILVIALLPPFYRLLHHLHGEKKDKKSSISGSSA*" /label="yhjN CDS" gene complement(1080495..1081649) /gene="yhjN" /locus_tag="BSU_10570" /old_locus_tag="BSU10570" /label="yhjN gene" S_feature complement(1081650..1081721) /Source="Nicolas_S_feature" /locus_tag="new_1132073_1132144_c" /HighExp="Cold, GM 15, GM 10, dia15, BC, BI, Salt, B60, Sw, GM 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S377" promotor_-10 complement(1081704..1081723) /Source="Nicolas_upshift_promotors" /id="U856" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.414585414585415" /psig="0.99000999000999" /xcortree=2773 /SigmaFactorBS="cataagaaaagtgaatcgcttatagaaaataattcataATTT CTttatcaacaaaaaTATACTATAGTAATAAATACattcactacgtgaacaattggag t" /listShort="S377, yhjN, S376" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1081720) /Source="Nicolas_upshifts" /id="U856" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.414585414585415" /psig="0.99000999000999" /xcortree=2773 /SigmaFactorBS="cataagaaaagtgaatcgcttatagaaaataattcataATTT CTttatcaacaaaaaTATACTATAGTAATAAATACattcactacgtgaacaattggag t" /listShort="S377, yhjN, S376" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1081737..1081742) /Source="Nicolas_upshift_promotors" /id="U856" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.414585414585415" /psig="0.99000999000999" /xcortree=2773 /SigmaFactorBS="cataagaaaagtgaatcgcttatagaaaataattcataATTT CTttatcaacaaaaaTATACTATAGTAATAAATACattcactacgtgaacaattggag t" /listShort="S377, yhjN, S376" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1081756..1082961) /gene="yhjO" /locus_tag="BSU_10580" /old_locus_tag="BSU10580" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease (recent HGT island)" /protein_id="NP_388939.1" /db_xref="EnsemblGenomes-Gn:BSU10580" /db_xref="EnsemblGenomes-Tr:CAB12898" /db_xref="GOA:O07569" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13081" /db_xref="UniProtKB/Swiss-Prot:O07569" /translation="MLTSFHSIKSRYTAPVRLRFFGELLTSLTGAMMGPFMVLYLHEQ LNGSIMMPMLIISLQPFADIFLTLAAGRVTDRLGRRTAILTALLLQSAAMTGFVFAEH AYVFAILYVMNGIGRSLYIPASRAQIAESTPESRRSEVFAVINAIYSTGLTAGPLVGM LLYNHNPVWIFALDAAALFIYFLIAALKLPETKPLHPAVTPKMSASFTIYRPVLLLLL LSLPISMLYAQTETTYRLFSKNMFSDYLSMLTIYSAAKALFSCVLQVPLVKGTEKLSM KTILFITYICYSLAAAGFACSTSLTMLLVTAAVMTVGESIGLTHIQTFISKLAPPHLL GRFYAVYGLHWDISRSIGPLAGGLILTSFGGEVIFYALAVCLLTAGLSLTYTIEKLEH KVIRKVNRL*" /label="yhjO CDS" gene complement(1081756..1082961) /gene="yhjO" /locus_tag="BSU_10580" /old_locus_tag="BSU10580" /label="yhjO gene" misc_feature 1082982..1083001 /Source="Nicolas_upshift_promotors" /id="U857" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.699300699300699" /psig="0.999000999001" /xcortree=2118 /SigmaFactorBS="tatctcgattttatagagtgaaaactggtcaacatgtgatcg ccgcctttcgctgTTTGATATAGTAGTAGTGTAtagaaggggcggcggcccaaaaagt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1082987 /Source="Nicolas_upshifts" /id="U857" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.699300699300699" /psig="0.999000999001" /xcortree=2118 /SigmaFactorBS="tatctcgattttatagagtgaaaactggtcaacatgtgatcg ccgcctttcgctgTTTGATATAGTAGTAGTGTAtagaaggggcggcggcccaaaaagt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 1083075..1084802 /gene="yhjP" /locus_tag="BSU_10590" /old_locus_tag="BSU10590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcription factor" /protein_id="NP_388940.1" /db_xref="EnsemblGenomes-Gn:BSU10590" /db_xref="EnsemblGenomes-Tr:CAB12899" /db_xref="GOA:O07570" /db_xref="InterPro:IPR000914" /db_xref="InterPro:IPR025370" /db_xref="InterPro:IPR030678" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG13082" /db_xref="UniProtKB/Swiss-Prot:O07570" /translation="MKLIEHYVALVKTGCAEYGQMNEMTLTEIADCLFCTERNAKLIL HKLENSNWIIRESGAGRGRKSKIAFLRRPEELLLQTAKEYTMSGKLKKAKELLQQYQS AFPGLQNEYNMWLSEVFGFVTETGENGAKDVLRLFITPESVSSLDPCQIFLRSEGHFV KQIFDTLFTFDSDMQEPKPHLVHGWEEVGKKQWRFFLRKGVLFHNGQPLTSRDVAFTF QRFLELADNPYKWLLHGVKQVLEKGPYCVELILDKPNALLPYALCDERLSILPAEQGG GKNGTGPFQMNQQHSGMLVLEANERYFKGRPYLDRVEFVFSEQAGEMNGFTIQEKQTC PEQQTVFDERHVQYLSLNLKKKGPLQHRSFRKALRLLISSERLVREAGGHRRIPVTSF LHPSPFEWEGVSPSELLKKSGYEGETIVLYTFSETDHREDAEWIQNICAQHGIRLTLQ FCDAADLRRPEIVQMADIIHDSATFYQDSEFGFLHLLLSENSFLYQHLSEKLTQICSG MTERMFSMPDRCSRINILRDIDRQMIQELNAIPLYQNVLQVTSSKNVKGLVLDEEGWI DLYSVWLSK*" /label="yhjP CDS" gene 1083075..1084802 /gene="yhjP" /locus_tag="BSU_10590" /old_locus_tag="BSU10590" /label="yhjP gene" promotor_-35 1084388..1084395 /Source="Nicolas_upshift_promotors" /id="U858" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.531468531468531" /psig="0.802197802197802" /xcortree=1827 /SigmaFactorBS="atcatcgtgaggacgccgaatggattcaaaaTATTTGCGccc agcacggtatcAGGCTTACACTTCAATTCTGtgatgctgctgatctgcgacggccgga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1084410..1084429 /Source="Nicolas_upshift_promotors" /id="U858" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.531468531468531" /psig="0.802197802197802" /xcortree=1827 /SigmaFactorBS="atcatcgtgaggacgccgaatggattcaaaaTATTTGCGccc agcacggtatcAGGCTTACACTTCAATTCTGtgatgctgctgatctgcgacggccgga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1084417 /Source="Nicolas_upshifts" /id="U858" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.531468531468531" /psig="0.802197802197802" /xcortree=1827 /SigmaFactorBS="atcatcgtgaggacgccgaatggattcaaaaTATTTGCGccc agcacggtatcAGGCTTACACTTCAATTCTGtgatgctgctgatctgcgacggccgga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1084832..1085158) /gene="yhjQ" /locus_tag="BSU_10600" /old_locus_tag="BSU10600" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12625841; Product type c: carrier" /codon_start=1 /transl_table=11 /product="putative metal-chelating cysteine-rich protein of unknown function" /protein_id="NP_388941.1" /db_xref="EnsemblGenomes-Gn:BSU10600" /db_xref="EnsemblGenomes-Tr:CAB12900" /db_xref="InterPro:IPR005560" /db_xref="PDB:5FIG" /db_xref="SubtiList:BG13083" /db_xref="UniProtKB/Swiss-Prot:O07571" /translation="MEQYSEACIEACIDCMKACNHCFTKCLEESVQHHLSGCIRLDRE CADICALAVKAMQTDSPFMKEICALCADICEACGTECGKHDHDHCQACAKACFTCAEQ CRSMAA*" /label="yhjQ CDS" gene complement(1084832..1085158) /gene="yhjQ" /locus_tag="BSU_10600" /old_locus_tag="BSU10600" /label="yhjQ gene" CDS complement(1085276..1085713) /gene="yhjR" /locus_tag="BSU_10610" /old_locus_tag="BSU10610" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22078549, 22882546; Product type c: carrier" /codon_start=1 /transl_table=11 /product="putative electron carrier protein (putative sporulation gene)" /protein_id="NP_388942.1" /db_xref="EnsemblGenomes-Gn:BSU10610" /db_xref="EnsemblGenomes-Tr:CAB12901" /db_xref="GOA:O07572" /db_xref="InterPro:IPR003251" /db_xref="InterPro:IPR009078" /db_xref="InterPro:IPR012347" /db_xref="SubtiList:BG13084" /db_xref="UniProtKB/Swiss-Prot:O07572" /translation="MHYSYYPYPVPYREDPVLIRNLQKAINGEFSAIQCYRKLAELAH SDEVRKQIEEIRRDEIRHLREFSTLYGSITGKHIMPKQTEECPDNFTRGLDAAFKDEQ ETVDFYLRAAEETSNLKAKGVFTRAARDEQNHAVWFLYYLMER*" /label="yhjR CDS" gene complement(1085276..1085713) /gene="yhjR" /locus_tag="BSU_10610" /old_locus_tag="BSU10610" /label="yhjR gene" downshifts complement(1085285) /Source="Nicolas_upshifts" /id="D578" /incds=0 /nref=1 /ntot=10 /MaxReadThrough="3.72767" /MaxDrop="3.86885" /score="16.2430017" /energy="-11.5" /TU="U859" /idTUdmin="U859" /TUdmin="-440" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1085744..1085763) /Source="Nicolas_upshift_promotors" /id="U859" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1267 /SigmaFactorBS="tggtaaaaacggccttttcacatataaaaagctgattatCTC CGCACATctctccctgcccAACATATACTTTTACAGAAGcccaattcctaagaatgga g" /listShort="yhjR, yhjQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1085764) /Source="Nicolas_upshifts" /id="U859" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1267 /SigmaFactorBS="tggtaaaaacggccttttcacatataaaaagctgattatCTC CGCACATctctccctgcccAACATATACTTTTACAGAAGcccaattcctaagaatgga g" /listShort="yhjR, yhjQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1085776..1085785) /Source="Nicolas_upshift_promotors" /id="U859" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1267 /SigmaFactorBS="tggtaaaaacggccttttcacatataaaaagctgattatCTC CGCACATctctccctgcccAACATATACTTTTACAGAAGcccaattcctaagaatgga g" /listShort="yhjR, yhjQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1085833..1085840 /Source="Nicolas_upshift_promotors" /id="U860" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.875124875124875" /psig=1 /xcortree=1809 /SigmaFactorBS="gaaaaggccgtttttaccaatagatcaGATTGGTCattttcg tcaacaTTCGATAAAATATAGAGAGAtaaaaagagaggggtcttctaatttgggagca g" /listShort="addB, addA, S378, sbcD, sbcC, yisB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1085854..1085873 /Source="Nicolas_upshift_promotors" /id="U860" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.875124875124875" /psig=1 /xcortree=1809 /SigmaFactorBS="gaaaaggccgtttttaccaatagatcaGATTGGTCattttcg tcaacaTTCGATAAAATATAGAGAGAtaaaaagagaggggtcttctaatttgggagca g" /listShort="addB, addA, S378, sbcD, sbcC, yisB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1085866 /Source="Nicolas_upshifts" /id="U860" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.875124875124875" /psig=1 /xcortree=1809 /SigmaFactorBS="gaaaaggccgtttttaccaatagatcaGATTGGTCattttcg tcaacaTTCGATAAAATATAGAGAGAtaaaaagagaggggtcttctaatttgggagca g" /listShort="addB, addA, S378, sbcD, sbcC, yisB" /GFF_Attribute="listLong" /label="upshifts" CDS 1085897..1089397 /gene="addB" /locus_tag="BSU_10620" /old_locus_tag="BSU10620" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:7746142, 8387145, 8510642, 8752323, 11544244, 16385024, 16780573, 19542287, 21071401, 22307084, 24670664, 26762979" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7746142, 8387145, 8510642, 8752323, 11544244, 16385024, 16780573, 19542287, 21071401, 22307084, 24670664, 26762979; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent deoxyribonuclease (subunit B)" /protein_id="NP_388943.2" /db_xref="EnsemblGenomes-Gn:BSU10620" /db_xref="EnsemblGenomes-Tr:CAB12902" /db_xref="GOA:P23477" /db_xref="InterPro:IPR014016" /db_xref="InterPro:IPR014017" /db_xref="InterPro:IPR014140" /db_xref="InterPro:IPR027417" /db_xref="PDB:3U44" /db_xref="PDB:3U4Q" /db_xref="PDB:4CEH" /db_xref="PDB:4CEI" /db_xref="PDB:4CEJ" /db_xref="SubtiList:BG10465" /db_xref="UniProtKB/Swiss-Prot:P23477" /translation="MGAEFLVGRSGSGKTKLIINSIQDELRRAPFGKPIIFLVPDQMT FLMEYELAKTPDMGGMIRAQVFSFSRLAWRVLQHTGGMSRPFLTSTGVQMLLRKLIEE HKQEFKVYQKASDKSGFTAQVERMLTEFKRYCLEPEDIRRMAESGTASEYRGERVLSE KLHDLSILYQQMEKSLADQYLHSEDYLTLLAEHIPLAEDIKGAHIYVDGFYQFTPQEF RVLEQLMVHAEHITFSLTADKPSYEREPHELELFRMTGKTYYRLHQKAKELNLDITYK ELSGTERHTKTPELAHLEAQYEARPAIPYAEKQEALTVMQAANRRAELEGIAREIHAL VREKGYRYKDVAILARQPEDYKDMVKEVFADYEIPYFIDGKASMLNHPLIEFIRSSLD VLKGNWRYEAVFRCVKTELLFPLNEPKAKVREQVDQLENYCIAYGIKGDRWTKGDRFQ YRRFVSLDDDFAQTDQEIEMENMLNDTRDWIVPPLFQLQKRMKKAKTVQEKAEALYRY LEETDVPLKLDQERQRAEDDGRIIEAQQHQQAWDAVIQLLEEFVEMMGDDEISLDLFQ QMIEAGAESLTFSLIPPALDQVFVGNMDLSRMYGTSCTFVLGANDGVLPARPDENGVL SDDDREWLKTIGVELSSGGRERLLDEHFLIYMAFSSPSDRLYVSYPIADAEGKTLLPS MIVKRLEELFPHHKERLLTNEPEQVSDEEQLMYVVNKSVAQSFTASQLRLWTREYDIS DVWWSTYNVLMSEQDRLQSKKLFSSLFFRNEVKQLERSVSRQLYGERIQGSVSRMETF NACPFSHFASHGLHLKERQFFKLEAPDIGQLFHSSLKLISDRLREQKLDWRDLTKEQC ELFSYDAVERLAPKLQKEILLSSNRHYYVKEKLQKIVTRVSGILSEHAKASGFVPIGL ELGFGGKGPLPPLTFQLKNGCTMELVGRIDRVDKAESSKGLLLRIVDYKSSDKGLDLA EVYYGLALQMLTYLDLSITHSADWLGMRATPAGVLYFHIHDPMIQSNLPLGLDEIEQE IFKKFKMKGLLLGDQEVVRLMDTTLQEGRSNIINAGLKKDGSLRSDSAAVGEKEFDLL TKHVRRTFQEAGEQITDGRVSIEPYKMKNKTPCTYCAFKSVCQFDESLEENEYRPLKA EKDKTILEWIKKEADGNEHS*" /label="addB CDS" gene 1085897..1089397 /gene="addB" /locus_tag="BSU_10620" /old_locus_tag="BSU10620" /label="addB gene" CDS 1089384..1093082 /gene="addA" /locus_tag="BSU_10630" /old_locus_tag="BSU10630" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:7746142, 8387145, 8510642, 8752323, 11544244, 16385024, 16780573, 19542287, 21071401, 22307084, 24670664, 26762979" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7746142, 8387145, 8510642, 8752323, 11544244, 16385024, 16780573, 19542287, 21071401, 22307084, 24670664, 26762979; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent deoxyribonuclease (subunit A)" /protein_id="NP_388944.2" /db_xref="EnsemblGenomes-Gn:BSU10630" /db_xref="EnsemblGenomes-Tr:CAB12903" /db_xref="GOA:P23478" /db_xref="InterPro:IPR000212" /db_xref="InterPro:IPR011335" /db_xref="InterPro:IPR011604" /db_xref="InterPro:IPR014016" /db_xref="InterPro:IPR014017" /db_xref="InterPro:IPR014152" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR034739" /db_xref="PDB:3U44" /db_xref="PDB:3U4Q" /db_xref="PDB:4CEH" /db_xref="PDB:4CEI" /db_xref="PDB:4CEJ" /db_xref="SubtiList:BG10466" /db_xref="UniProtKB/Swiss-Prot:P23478" /translation="MNIPKPADSTWTDDQWNAIVSTGQDILVAAAAGSGKTAVLVERM IRKITAEENPIDVDRLLVVTFTNASAAEMKHRIAEALEKELVQRPGSLHIRRQLSLLN RASISTLHSFCLQVLKKYYYLIDLDPGFRIADQTEGELIGDEVLDELFEDEYAKGEKA FFELVDRYTTDRHDLDLQFLVKQVYEYSRSHPNPEAWLESFVHLYDVSEKSAIEELPF YQYVKEDIAMVLNGAKEKLLRALELTKAPGGPAPRADNFLDDLAQIDELIQHQDDFSE LYKRVPAVSFKRAKAVKGDEFDPALLDEATDLRNGAKKLLEKLKTDYFTRSPEQHLKS LAEMKPVIETLVQLVISYGKRFEAAKQEKSIIDFSDLEHYCLAILTAENDKGEREPSE AARFYQEQFHEVLVDEYQDTNLVQESILQLVTSGPEETGNLFMVGDVKQSIYRFRLAE PLLFLSKYKRFTESGEGTGRKIDLNKNFRSRADILDSTNFLFKQLMGGKIGEVDYDEQ AELKLGAAYPDNDETETELLLIDNAEDTDASEEAEELETVQFEAKAIAKEIRKLISSP FKVYDGKKKTHRNIQYRDIVILLRSMPWAPQIMEELRAQGIPVYANLTSGYFEAVEVA VALSVLKVIDNPYQDIPLASVLRSPIVGADENELSLIRLENKKAPYYEAMKDYLAAGD RSDELYQKLNTFYGHLQKWRAFSKNHSVSELIWEVYRDTKYMDYVGGMPGGKQRQANL RVLYDRARQYESTAFRGLFRFLRFIERMQERGDDLGTARALSEQEDVVRLMTIHSSKG LEFPVVFVAGLGRNFNMMDLNKSYLLDKELGFGTKYIHPQLRISYPTLPLIAMKKKMR RELLSEELRVLYVALTRAKEKLFLIGSCKDHQKQLAKWQASASQTDWLLPEFDRYQAR TYLDFIGPALARHRDLGDLAGVPAHADISGHPARFAVQMIHSYDLLDDDLEERMEEKS ERLEAIRRGEPVPGSFAFDEKAREQLSWTYPHQEVTQIRTKQSVSEIKRKREYEDEYS GRAPVKPADGSILYRRPAFMMKKGLTAAEKGTAMHTVMQHIPLSHVPSIEEAEQTVHR LYEKELLTEEQKDAIDIEEIVQFFHTEIGGQLIGAKWKDREIPFSLALPAKEIYPDAH EADEPLLVQGIIDCLYETEDGLYLLDYKSDRIEGKFQHGFEGAAPILKKRYETQIQLY TKAVEQIAKTKVKGCALYFFDGGHILTL*" /label="addA CDS" gene 1089384..1093082 /gene="addA" /locus_tag="BSU_10630" /old_locus_tag="BSU10630" /label="addA gene" S_feature 1093083..1093153 /Source="Nicolas_S_feature" /locus_tag="new_1143506_1143576" /HighExp="H2O2, C90, Heat, LBGtran, dia15, HiTm, Diami, C30, Lbtran, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S378" CDS 1093154..1094329 /gene="sbcD" /locus_tag="BSU_10640" /old_locus_tag="BSU10640" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:7968921, 8493111, 16780573" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7968921, 8493111, 16780573; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA repair exonuclease" /protein_id="NP_388945.3" /db_xref="EnsemblGenomes-Gn:BSU10640" /db_xref="EnsemblGenomes-Tr:CAB12904" /db_xref="GOA:P23479" /db_xref="InterPro:IPR004593" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR026843" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG10467" /db_xref="UniProtKB/Swiss-Prot:P23479" /translation="MRILHTADWHLGKTLEGRSRLSEQADVLDELNTIVKDEQIDAIV MAGDAFDTVNPPALAEQLFYESLSALSDRGKRPIVVIAGNHDNPDRLSAASPLTHENG IHLIGYPTTEPIHIEVPSAGELLAVGALAYPSEARLNEVLSDTFDEKLLRDHYDVKIR QAFEHMTSRFRTDAVKIAASHIYVAGGNQTDSERPIEVGGAYTVAAESLPADAAYVAL GHLHRPQTIKRARTLARYSGSPLAYSFSEAGYAKSVTIVDAKPGEEATWQEVLLSSGK PLVKWKAANGLSEVYSWLDEGRDQNAWIDLEIRVADQLSLEEIHRLRKAHPGFIHIRP VFEEQNKDRERIEVKHVSIEDRFKKFYEKQTGGAVPDEEMVKLFLELASGVEEEDAK* " /label="sbcD CDS" gene 1093154..1094329 /gene="sbcD" /locus_tag="BSU_10640" /old_locus_tag="BSU10640" /label="sbcD gene" CDS 1094326..1097718 /gene="sbcC" /locus_tag="BSU_10650" /old_locus_tag="BSU10650" /function="16.9: Replicate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16780573, 19906728" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16780573, 19906728; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA ATP-dependent repair enzyme" /protein_id="NP_388946.2" /db_xref="EnsemblGenomes-Gn:BSU10650" /db_xref="EnsemblGenomes-Tr:CAB12905" /db_xref="GOA:O06714" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13088" /db_xref="UniProtKB/Swiss-Prot:O06714" /translation="MKPIALSIKGLHSFREEQTIDFEGLSGAGVFGIFGPTGSGKSSI LDAMTLALYGKVERAANNTHGILNHAEDTLSVSFTFALQTNHQISYKVERVFKRTDEM KVKTALCRFIEIKDEHTVLADKASEVNKRVEELLGLTIDDFTRAVVLPQGKFAEFLSL KGAERRHMLQRLFNLEQYGDRLVKKLRRQAQEANARKNEMLAEQSGLGEASSEAVEQA EKVLEQAEARLEAMRKNRDQAKERFTEHQEIWNVQKEKSTYEEEEKRLAEEQPHIDSM QKRLLEAETAAALKPYADRYAEAIQHEEQAEKEQTLAQKDLADRTAFFQQKHEEYEAW RQHKSEKEPELLAKQEQLSRLQEIEIKLSEAKQEEERKKADLRQKEEALQSVMNELET VTDRLTRGQNRQTELKQQLKSLQVTSDERKSCQQAAEMALRIRQTEEQIKKEKKRSEE LNLVLQKMNEEKNTLVQKTEAEENNIIQAYEAVQTVYHLVCETERSLTRMTEEARKSQ HTLHLQREKARVALLTKELAQKLTAGKPCPVCGSTDHDPSASVHETYEADSHLEEDIK RTDVLLTEAAALSQEILSAKIMLEEQSARFIEQCPFLQTIQAQNLEAAASFEHQPVYE AFETAKFEWKRIKQDILSVKTRMAQMIGAYQESLKKAEQLNEKIGFEKREADRIESII SELQSSMDSSLNMFKEAFQNQSVDEAEKWQQAIEEKDRAAEECEKRIEKSIAFLAEHE AQKEKLRESGHRLEREKLELHYAAERIKSVIADYEHELGDYAKGDSIQIKLRSVQQDL KLLKEKEQSLYEELQSAQMKLNQAKSRASASELTLQEAKGRLEKAKAAWLEHTKNTSI TRTEEVEQSLIPADELEKMKTGIDQFMDKLKQNAANLKRVAEILAGRALSESEWNETV AALQEAEDAFGAAIEEKGAAAKALAVIRDHHKRFNEIEAELKKWQMHIDRLDKLQAVF KGNTFVEFLAEEQLESVARDASARLSMLTRQRYAIEVDSEGGFVMRDDANGGVRRPVS SLSGGETFLTSLSLALALSAQIQLRGEYPLQFFFLDEGFGTLDQDLLDTVVTALEKLQ SDNLAVGVISHVQELRARLPKKLIVHPAEPSGRGTRVSLELM*" /label="sbcC CDS" gene 1094326..1097718 /gene="sbcC" /locus_tag="BSU_10650" /old_locus_tag="BSU10650" /label="sbcC gene" promotor_-35 1096973..1096979 /Source="Nicolas_upshift_promotors" /id="U861" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=813 /SigmaFactorBS="tgaaaagatgaaaaccggcatagaccagtttaTGGATAAact gaagcaaaatgCTGCAAACTTAAaacgagtagcagagatacttgccggcagagcatta t" /listShort="yisB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1096994..1097005 /Source="Nicolas_upshift_promotors" /id="U861" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=813 /SigmaFactorBS="tgaaaagatgaaaaccggcatagaccagtttaTGGATAAact gaagcaaaatgCTGCAAACTTAAaacgagtagcagagatacttgccggcagagcatta t" /listShort="yisB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1097001 /Source="Nicolas_upshifts" /id="U861" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=813 /SigmaFactorBS="tgaaaagatgaaaaccggcatagaccagtttaTGGATAAact gaagcaaaatgCTGCAAACTTAAaacgagtagcagagatacttgccggcagagcatta t" /listShort="yisB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1097070..1098043) /Source="Nicolas_S_feature" /locus_tag="new_1147493_1148466_c" /HighExp="S6, S8, S7, BT, C30, B36, S5, C90, Pyr, B60" /AntisenseName="yisB" /AntisenseCor="0.19649597897587401" /AntisenseRegPval="-2.9" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="SigK" /TUlongPSig="0.992" /label="S379" CDS 1097732..1098034 /gene="hlpB" /locus_tag="BSU_10660" /old_locus_tag="BSU10660" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16780573, 22984257" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16780573, 22984257; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="HNH nuclease-like essential for DNA repair" /protein_id="NP_388947.1" /db_xref="EnsemblGenomes-Gn:BSU10660" /db_xref="EnsemblGenomes-Tr:CAB12906" /db_xref="SubtiList:BG13089" /db_xref="UniProtKB/Swiss-Prot:O06715" /translation="MAKQIAGICELCGRSDVQLTEHHLTPKEEGGTFLPTAMLCIPCH KQIHALYTNQELAVRLNGMAELRSDPELARFVKWIRKQPPEKLIKTKKSNERKKKK*" /label="hlpB CDS" gene 1097732..1098034 /gene="hlpB" /locus_tag="BSU_10660" /old_locus_tag="BSU10660" /label="hlpB gene" downshifts 1098014 /Source="Nicolas_upshifts" /id="D579" /incds=0 /nref=230 /ntot=269 /MaxReadThrough="1.42126" /MaxDrop="6.71114" /score="0.317490594" /energy="-14.3" /TU="NA" /idTUdmin="U861" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(1098071..1098289) /gene="gerPF" /locus_tag="BSU_10670" /old_locus_tag="BSU10670" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10715007, 20161744" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10715007, 20161744; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination protein" /protein_id="NP_388948.2" /db_xref="EnsemblGenomes-Gn:BSU10670" /db_xref="EnsemblGenomes-Tr:CAB12907" /db_xref="GOA:O06716" /db_xref="InterPro:IPR019618" /db_xref="SubtiList:BG13090" /db_xref="UniProtKB/Swiss-Prot:O06716" /translation="MPAIVGPIAINSISGGVVNFGDSFYLSPKSSSKSALGSGAGNTG DFLLLNNAVNATNYIDPDVNDQDMVGNG*" /label="gerPF CDS" gene complement(1098071..1098289) /gene="gerPF" /locus_tag="BSU_10670" /old_locus_tag="BSU10670" /label="gerPF gene" downshifts complement(1098088) /Source="Nicolas_upshifts" /id="D580" /incds=0 /nref=40 /ntot=66 /MaxReadThrough="3.93344" /MaxDrop="5.39228" /score="13.5435041" /energy="-15.3" /TU="U863" /idTUdmin="U863" /TUdmin="-989" /isTUend="FALSE" /label="downshifts" CDS complement(1098321..1098722) /gene="gerPE" /locus_tag="BSU_10680" /old_locus_tag="BSU10680" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10715007" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10715007; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination protein" /protein_id="NP_388949.1" /db_xref="EnsemblGenomes-Gn:BSU10680" /db_xref="EnsemblGenomes-Tr:CAB12908" /db_xref="GOA:O06717" /db_xref="InterPro:IPR024496" /db_xref="SubtiList:BG13091" /db_xref="UniProtKB/Swiss-Prot:O06717" /translation="MLKRISRIRLVKFNSLGIASVFQVGDTNEIDMSVKVFAVQRSLS TFYHNEGSFNKKEYQIFQQQAVKPLPETGVQSAFCHEVPAIYVRSIKIQGVSASSVLH AGSASLIRGDARLKHIRQIQSPRSQSPAKNI*" /label="gerPE CDS" gene complement(1098321..1098722) /gene="gerPE" /locus_tag="BSU_10680" /old_locus_tag="BSU10680" /label="gerPE gene" CDS complement(1098722..1098898) /gene="gerPD" /locus_tag="BSU_10690" /old_locus_tag="BSU10690" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10715007" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10715007; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination protein" /protein_id="NP_388950.1" /db_xref="EnsemblGenomes-Gn:BSU10690" /db_xref="EnsemblGenomes-Tr:CAB12909" /db_xref="GOA:O06718" /db_xref="InterPro:IPR017257" /db_xref="SubtiList:BG13092" /db_xref="UniProtKB/Swiss-Prot:O06718" /translation="MIFTVINRSLEVGDIRMNGVSSSSVFHIGDTESIYLSSIFDTPP ESLIIGPFAPLAPE*" /label="gerPD CDS" gene complement(1098722..1098898) /gene="gerPD" /locus_tag="BSU_10690" /old_locus_tag="BSU10690" /label="gerPD gene" CDS complement(1098895..1099512) /gene="gerPC" /locus_tag="BSU_10700" /old_locus_tag="BSU10700" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10715007" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10715007; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination protein" /protein_id="NP_388951.1" /db_xref="EnsemblGenomes-Gn:BSU10700" /db_xref="EnsemblGenomes-Tr:CAB12910" /db_xref="GOA:O06719" /db_xref="InterPro:IPR019673" /db_xref="SubtiList:BG13093" /db_xref="UniProtKB/Swiss-Prot:O06719" /translation="MYDQSVSSYLQNLNSFVQQQAIHIQQLERQLKEIQTEMNTMKQR PATTIERVEYKFDQLKIERLDGTLNIGLNPTDPNSVQNFDVSQSTPQIGMMQQEESAQ LMQQIRQNVDMYLTEEIPDILEQLENQYDSRLDDTNRHHVIEDIRKQMDSRIHYYMSH IKKEENTPPAQYAEHIAEHVKRDVIRAVEHFLEHIPSEMKGDEQA*" /label="gerPC CDS" gene complement(1098895..1099512) /gene="gerPC" /locus_tag="BSU_10700" /old_locus_tag="BSU10700" /label="gerPC gene" CDS complement(1099535..1099768) /gene="gerPB" /locus_tag="BSU_10710" /old_locus_tag="BSU10710" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10715007" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10715007; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination protein" /protein_id="NP_388952.2" /db_xref="EnsemblGenomes-Gn:BSU10710" /db_xref="EnsemblGenomes-Tr:CAB12911" /db_xref="GOA:O06720" /db_xref="InterPro:IPR024255" /db_xref="SubtiList:BG13094" /db_xref="UniProtKB/Swiss-Prot:O06720" /translation="MNFYINQTIQINYLRLESISNSSILQIGSAGSIKSLSNLYNTGS YVEPAPEVSGSGQPLQLQEPDTGSLVPLQPPGR*" /label="gerPB CDS" gene complement(1099535..1099768) /gene="gerPB" /locus_tag="BSU_10710" /old_locus_tag="BSU10710" /label="gerPB gene" CDS complement(1099783..1100004) /gene="gerPA" /locus_tag="BSU_10720" /old_locus_tag="BSU10720" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10715007" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10715007; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination protein" /protein_id="NP_388953.1" /db_xref="EnsemblGenomes-Gn:BSU10720" /db_xref="EnsemblGenomes-Tr:CAB12912" /db_xref="GOA:O06721" /db_xref="InterPro:IPR019618" /db_xref="SubtiList:BG13095" /db_xref="UniProtKB/Swiss-Prot:O06721" /translation="MPAIVGAFKINAIGTSGVVHIGDCITISPQAQVRTFAGAGSFNT GDSLKVMNYQNATNVYDNDAVDQPIVANA*" /label="gerPA CDS" gene complement(1099783..1100004) /gene="gerPA" /locus_tag="BSU_10720" /old_locus_tag="BSU10720" /label="gerPA gene" S_feature complement(1100005..1100091) /Source="Nicolas_S_feature" /locus_tag="new_1150428_1150514_c" /HighExp="S6, S8, S7, S5, BT, B36, B60, G/S, Pyr, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="SigK" /TUlongPSig="0.992" /label="S380" promotor_-35 1100019..1100025 /Source="Nicolas_upshift_promotors" /id="U862" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig="0.733266733266733" /xcortree=136 /SigmaFactorBS="aaacgctccgacaatggccggcatacgagcacatccttTGTT GAAaaattaaaaaaagACAGGTAAAGTGAAATGACAattccgatttcaattgggctat t" /listShort="S381, S385" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1100039..1100058 /Source="Nicolas_upshift_promotors" /id="U862" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig="0.733266733266733" /xcortree=136 /SigmaFactorBS="aaacgctccgacaatggccggcatacgagcacatccttTGTT GAAaaattaaaaaaagACAGGTAAAGTGAAATGACAattccgatttcaattgggctat t" /listShort="S381, S385" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1100041..1100696 /Source="Nicolas_S_feature" /locus_tag="new_1150464_1151119" /HighExp="Salt, BC, Sw, S8, Heat, M9-stat, S7, Etha, BMM, Lbtran" /AntisenseName="yisI" /AntisenseCor="3.97396613023396E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="0.17396" /TUshortSig="SigA" /TUshortPSig="0.733" /TUlongSig="NA" /TUlongPSig="NA" /label="S381" upshifts 1100041 /Source="Nicolas_upshifts" /id="U862" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig="0.733266733266733" /xcortree=136 /SigmaFactorBS="aaacgctccgacaatggccggcatacgagcacatccttTGTT GAAaaattaaaaaaagACAGGTAAAGTGAAATGACAattccgatttcaattgggctat t" /listShort="S381, S385" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1100078..1100097) /Source="Nicolas_upshift_promotors" /id="U863" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1293 /SigmaFactorBS="ttcacaaagagccgatatgtccccttaaaattTCTCTCACAC atatgtgcgtttGTCATAAGCTATCGTGAATAgcccaattgaaatcggaattgtcatt t" /listShort="S380, gerPA, gerPB, gerPC, gerPD, gerPE, gerPF, S379" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1100091) /Source="Nicolas_upshifts" /id="U863" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1293 /SigmaFactorBS="ttcacaaagagccgatatgtccccttaaaattTCTCTCACAC atatgtgcgtttGTCATAAGCTATCGTGAATAgcccaattgaaatcggaattgtcatt t" /listShort="S380, gerPA, gerPB, gerPC, gerPD, gerPE, gerPF, S379" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1100093..1100222) /Source="Nicolas_S_feature" /locus_tag="new_1150516_1150645_c" /HighExp="S6, S8, S7, T5.0H, T3.30H, T4.0H, S5, T3.0H, T2.30H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S382" promotor_-35 complement(1100110..1100119) /Source="Nicolas_upshift_promotors" /id="U863" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1293 /SigmaFactorBS="ttcacaaagagccgatatgtccccttaaaattTCTCTCACAC atatgtgcgtttGTCATAAGCTATCGTGAATAgcccaattgaaatcggaattgtcatt t" /listShort="S380, gerPA, gerPB, gerPC, gerPD, gerPE, gerPF, S379" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(1100224..1100426) /Source="Nicolas_S_feature" /locus_tag="new_1150647_1150849_c" /HighExp="T5.0H, T4.0H, T3.30H, S6, M9-stat, T3.0H, S8, S7, T2.30H, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.976, 0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S383" downshifts complement(1100267) /Source="Nicolas_upshifts" /id="D581" /incds=0 /nref=13 /ntot=116 /MaxReadThrough="3.97434" /MaxDrop="3.59184" /score="13.5435041" /energy="-15.3" /TU="U865" /idTUdmin="U864" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1100427..1100597) /gene="pchI" /locus_tag="BSU_10730" /old_locus_tag="BSU10730" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11679073, 27542896" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11679073, 27542896; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="Spo0A-P phosphatase (iron-metabolism related)" /protein_id="NP_388954.1" /db_xref="EnsemblGenomes-Gn:BSU10730" /db_xref="EnsemblGenomes-Tr:CAB12913" /db_xref="GOA:O06722" /db_xref="InterPro:IPR018540" /db_xref="InterPro:IPR037208" /db_xref="SubtiList:BG13096" /db_xref="UniProtKB/Swiss-Prot:O06722" /translation="MNSKIEEMRITLIETAQKYGMNSKETIQCSQELDILLNTRIKEE MIFGRYLENSRM*" /label="pchI CDS" gene complement(1100427..1100597) /gene="pchI" /locus_tag="BSU_10730" /old_locus_tag="BSU10730" /label="pchI gene" misc_feature complement(1100641..1100660) /Source="Nicolas_upshift_promotors" /id="U864" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.386613386613387" /psig="0.976023976023976" /xcortree=2921 /SigmaFactorBS="gcttttttagtcaaattgacgaaaggcaaccttttgagccaa aaTAGGTTATACTAACGATATCctgtatttatatcaaaataaaatctagaattggaga t" /listShort="yisI, S383" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1100644) /Source="Nicolas_upshifts" /id="U864" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.386613386613387" /psig="0.976023976023976" /xcortree=2921 /SigmaFactorBS="gcttttttagtcaaattgacgaaaggcaaccttttgagccaa aaTAGGTTATACTAACGATATCctgtatttatatcaaaataaaatctagaattggaga t" /listShort="yisI, S383" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1100646..1100742) /Source="Nicolas_S_feature" /locus_tag="new_1151069_1151165_c" /HighExp="S6, S8, S7, S5, BT, Pyr, G/S, Glucon, SMMPr, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S384" downshifts 1100653 /Source="Nicolas_upshifts" /id="D582" /incds=0 /nref=3 /ntot=54 /MaxReadThrough="4.52913" /MaxDrop="3.35342" /score="12.6645711" /energy="-10.3" /TU="U862" /idTUdmin="U862" /TUdmin="-176" /isTUend="FALSE" /label="downshifts" S_feature 1100698..1100862 /Source="Nicolas_S_feature" /locus_tag="new_1151121_1151285" /HighExp="Salt, S8, S7, BC, Heat, H2O2, Sw, Oxctl, MG-0.2, MG-0.1" /AntisenseName="yisJ" /AntisenseCor="0.24461808844813801" /AntisenseRegPval="-4.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.733" /TUlongSig="NA" /TUlongPSig="NA" /label="S385" CDS complement(1100743..1101666) /gene="yisJ" /locus_tag="BSU_10740" /old_locus_tag="BSU10740" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative spore coat protein, CotH paralog" /protein_id="NP_388955.1" /db_xref="EnsemblGenomes-Gn:BSU10740" /db_xref="EnsemblGenomes-Tr:CAB12914" /db_xref="GOA:O06723" /db_xref="InterPro:IPR014867" /db_xref="SubtiList:BG13097" /db_xref="UniProtKB/Swiss-Prot:O06723" /translation="MERVHLFFHREQLKRKGTAKGLFVTDRSVSPILLTQRDRAEKAS YEISWEKSLLGERTLFLNAEQDDPSLMRRRLAYCFFDQIGVPAPVASYSFLTINGQPE GIYLNIKNHQPAGKRSYGVKTADPRVPLSLFNNDSSAFLHEFFILIRTAGDDELAERI KLYLDVKLFFLWLIGNTCTNQGFYYTFCLNESGRLYVSPMETRSLAVQEWYEEDPLLT KGKTLSSRLLSIPAFRSQYHTLMKNVLKRSFTIERLSPLINEWHLDICQSAADDPFIK KSPFQIEKEQTNILREIEERQDFLQAHLARL*" /label="yisJ CDS" gene complement(1100743..1101666) /gene="yisJ" /locus_tag="BSU_10740" /old_locus_tag="BSU10740" /label="yisJ gene" promotor_-10 complement(1101688..1101707) /Source="Nicolas_upshift_promotors" /id="U865" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1372 /SigmaFactorBS="aaatccctttttctcaattccgttttcatTTCGTTTCAGgac gggcttgctcTACATATCATACAAATGTCGttttgagaaggaggaaagaatatggagc g" /listShort="yisJ, S384, yisI, S383, S382" /listLong="S380, gerPA, gerPB, gerPC, gerPD, gerPE, gerPF, S379" /label="promotor_-10" upshifts complement(1101699) /Source="Nicolas_upshifts" /id="U865" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1372 /SigmaFactorBS="aaatccctttttctcaattccgttttcatTTCGTTTCAGgac gggcttgctcTACATATCATACAAATGTCGttttgagaaggaggaaagaatatggagc g" /listShort="yisJ, S384, yisI, S383, S382" /listLong="S380, gerPA, gerPB, gerPC, gerPD, gerPE, gerPF, S379" /label="upshifts" promotor_-35 complement(1101721..1101730) /Source="Nicolas_upshift_promotors" /id="U865" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1372 /SigmaFactorBS="aaatccctttttctcaattccgttttcatTTCGTTTCAGgac gggcttgctcTACATATCATACAAATGTCGttttgagaaggaggaaagaatatggagc g" /listShort="yisJ, S384, yisI, S383, S382" /listLong="S380, gerPA, gerPB, gerPC, gerPD, gerPE, gerPF, S379" /label="promotor_-35" promotor_-35 1101750..1101758 /Source="Nicolas_upshift_promotors" /id="U866" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=553 /SigmaFactorBS="cccgtcctgaaacgaaatgaaaacggaattgagaaAAAGGGA TTtcagcattcgaCAGAGAATACATGAAGGAGcattctgatttaaaagatgatggagg a" /listShort="yisK, S386, yisL" /listLong="wprA" /label="promotor_-35" promotor_-10 1101770..1101788 /Source="Nicolas_upshift_promotors" /id="U866" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=553 /SigmaFactorBS="cccgtcctgaaacgaaatgaaaacggaattgagaaAAAGGGA TTtcagcattcgaCAGAGAATACATGAAGGAGcattctgatttaaaagatgatggagg a" /listShort="yisK, S386, yisL" /listLong="wprA" /label="promotor_-10" upshifts 1101775 /Source="Nicolas_upshifts" /id="U866" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=553 /SigmaFactorBS="cccgtcctgaaacgaaatgaaaacggaattgagaaAAAGGGA TTtcagcattcgaCAGAGAATACATGAAGGAGcattctgatttaaaagatgatggagg a" /listShort="yisK, S386, yisL" /listLong="wprA" /label="upshifts" CDS 1101821..1102726 /gene="mblK" /locus_tag="BSU_10750" /old_locus_tag="BSU10750" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16847875, 27215790, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16847875, 27215790, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="hydrolase/isomerase involved in remodelling the bacterial envelope" /protein_id="NP_388956.1" /db_xref="EnsemblGenomes-Gn:BSU10750" /db_xref="EnsemblGenomes-Tr:CAB12915" /db_xref="GOA:O06724" /db_xref="InterPro:IPR011234" /db_xref="InterPro:IPR036663" /db_xref="SubtiList:BG13098" /db_xref="UniProtKB/Swiss-Prot:O06724" /translation="MKFATGELYNRMFVGLIIDDEKIMDLQKAEKKLFELETIPGSLI ECIAEGDKFVAHARQLAEWAKKPNDELGSFMYSLSEVKLHAPIPKPSKNIICIGKNYR DHAIEMGSEADIPEHPMVFTKSPVTVTGHGDIVKSHEEVTSQLDYEGELAVVIGKSGT RISKEDAYDHVFGYTIVNDITARDLQKRHKQFFIGKSLDTTCPMGPVLVHKSSIQEPE RLKVETRVNGELRQSGSASDMIFSIPELIETLSKGMTLEAGDIIATGTPSGVGKGFTP PKFLRSGDKIDITIDPIGTLSNQIG*" /label="mblK CDS" gene 1101821..1102726 /gene="mblK" /locus_tag="BSU_10750" /old_locus_tag="BSU10750" /label="mblK gene" S_feature 1102727..1102807 /Source="Nicolas_S_feature" /locus_tag="new_1153150_1153230" /HighExp="S2, Lbstat, S1, Etha, SMMPr, M0t90, M40t90, LoTm, T-4.40H, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S386" promotor_-35 1102777..1102780 /Source="Nicolas_upshift_promotors" /id="U867" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.851148851148851" /psig=1 /xcortree=2462 /SigmaFactorBS="gacccgcccgttttttctgataatcatcTTTGtgacagagga caagttCATGGTACTATAAGTGGGGTaatttatctgatagggggaacatatatgacac a" /listShort="yisL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1102797..1102816 /Source="Nicolas_upshift_promotors" /id="U867" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.851148851148851" /psig=1 /xcortree=2462 /SigmaFactorBS="gacccgcccgttttttctgataatcatcTTTGtgacagagga caagttCATGGTACTATAAGTGGGGTaatttatctgatagggggaacatatatgacac a" /listShort="yisL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1102809 /Source="Nicolas_upshifts" /id="U867" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.851148851148851" /psig=1 /xcortree=2462 /SigmaFactorBS="gacccgcccgttttttctgataatcatcTTTGtgacagagga caagttCATGGTACTATAAGTGGGGTaatttatctgatagggggaacatatatgacac a" /listShort="yisL" /GFF_Attribute="listLong" /label="upshifts" CDS 1102842..1103198 /gene="yisL" /locus_tag="BSU_10760" /old_locus_tag="BSU10760" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 27215790; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_388957.1" /db_xref="EnsemblGenomes-Gn:BSU10760" /db_xref="EnsemblGenomes-Tr:CAB12916" /db_xref="GOA:O06725" /db_xref="InterPro:IPR010899" /db_xref="SubtiList:BG13099" /db_xref="UniProtKB/Swiss-Prot:O06725" /translation="MTHLHITTWVVALILLFVSYSLYSSGSAKGAKITHMILRLFYIL IILTGAELFVRFANWNGEYAGKMILGIITIGLMEMLLIRKKKEKSTGGLWVGFVIVLL LTVLLGLHLPIGFQLF*" /label="yisL CDS" gene 1102842..1103198 /gene="yisL" /locus_tag="BSU_10760" /old_locus_tag="BSU10760" /label="yisL gene" downshifts 1103095 /Source="Nicolas_upshifts" /id="D583" /incds=1 /nref=1 /ntot=44 /MaxReadThrough="4.28837" /MaxDrop="2.46999" /score="41.4247437" /energy="-11.7" /TU="U866,U867" /idTUdmin="U867" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" downshifts 1103186 /Source="Nicolas_upshifts" /id="D584" /incds=0 /nref=17 /ntot=162 /MaxReadThrough="3.06092" /MaxDrop="3.41506" /score="41.4247437" /energy="-11.7" /TU="U866" /idTUdmin="U867" /TUdmin=3 /isTUend="TRUE" /label="downshifts" upshifts 1103319 /Source="Nicolas_upshifts" /id="U868" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.486513486513487" /psig="0.732267732267732" /xcortree=2782 /SigmaFactorBS="atattccaaatcatttaaaataaccttaaaattccctgtaag cggtatctcgtcctatgaaatTATGATACCTTCAAGGAGATtcattattttgcaggag g" /listShort="wprA" /GFF_Attribute="listLong" /label="upshifts" misc_feature 1103322..1103341 /Source="Nicolas_upshift_promotors" /id="U868" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.486513486513487" /psig="0.732267732267732" /xcortree=2782 /SigmaFactorBS="atattccaaatcatttaaaataaccttaaaattccctgtaag cggtatctcgtcctatgaaatTATGATACCTTCAAGGAGATtcattattttgcaggag g" /listShort="wprA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 1103366..1106050 /gene="wprA" /locus_tag="BSU_10770" /old_locus_tag="BSU10770" /EC_number="3.4.21.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9004506, 9675284, 10336490, 15205417, 17269748, 21636651, 23180473, 25313396" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9004506, 9675284, 10336490, 15205417, 17269748, 21636651, 23180473, 25313396; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cell wall-associated protease" /protein_id="NP_388958.1" /db_xref="EnsemblGenomes-Gn:BSU10770" /db_xref="EnsemblGenomes-Tr:CAB12917" /db_xref="GOA:P54423" /db_xref="InterPro:IPR000209" /db_xref="InterPro:IPR015500" /db_xref="InterPro:IPR022398" /db_xref="InterPro:IPR023828" /db_xref="InterPro:IPR034084" /db_xref="InterPro:IPR036852" /db_xref="SubtiList:BG11846" /db_xref="UniProtKB/Swiss-Prot:P54423" /translation="MKRRKFSSVVAAVLIFALIFSLFSPGTKAAAAGAIDQAAALENG KEQTGAMKEPEQVKWYKVTPGATDIQKNSHMALTVKSDSVLNVSVYPSKEKALKDETF EMYRSFTAEDGKSEVIFPYAWSGPYYVKVEYLGEEEPEDGGTAEAAAEAKYTIGYKGT KKQPSDLEEEEACPVEMSVDQKKSGKGILDKLRSIRDEQLSQTAEGKELTSLYYKAAP FIVAKLALNKTARNEIYQDLVTLKPLFDDVSENGASSSYKVTEKDQKAINRLYDKALQ SVPSFLKEEIKKQADRLNMKQLQGKTAGAILTENNIAAKSEVQTTKVIFKVKDNKSLS SVHNEMKGFSASAQSKKDISNVKKAKKLFDNLYSFELPKDEKQNGAYTASAKRVKSAA ATLSKMSNVEFAEPVQEYKSLANDIQYPYQWPLKNNGENGGVKNADVKYEPANTLLSK RKLNDTLIAVVDTGVDSTLADLKGKVRTDLGHNFVGRNNNAMDDQGHGTHVAGIIAAQ SDNGYSMTGLNAKAKIIPVKVLDSAGSGDTEQIALGIKYAADKGAKVINLSLGGGYSR VLEFALKYAADKNVLIAAASGNDGENALSYPASSKYVMSVGATNRMDMTADFSNYGKG LDISAPGSDIPSLVPNGNVTYMSGTSMATPYAAAAAGLLFAQNPKLKRTEVEDMLKKT ADDISFESVDGGEEELYDDYGDPIEIPKTPGVDWHSGYGRLNVMKAVSAADLQLKVNK LESTQTAVRGSAKEGTLIEVMNGKKKLGSAKAGKDNAFKVNIATQKQDQVLYLKATKG DAKTSYKVVVVKGKPSGTPKVNAVKTKDTAVKGKANSKAMIRVKNKSKKVIASAKADA KGTFSVKIKKQKAGTVLYVTAVDTDKKESKEAKVVVEK*" /label="wprA CDS" gene 1103366..1106050 /gene="wprA" /locus_tag="BSU_10770" /old_locus_tag="BSU10770" /label="wprA gene" downshifts complement(1103534) /Source="Nicolas_upshifts" /id="D585" /incds=1 /nref=2 /ntot=155 /MaxReadThrough="0.14981" /MaxDrop="3.98572" /score="9.01750245" /energy="-8" /TU="NA" /idTUdmin="U869" /TUdmin=2563 /isTUend="FALSE" /label="downshifts" downshifts 1106042 /Source="Nicolas_upshifts" /id="D586" /incds=0 /nref=239 /ntot=267 /MaxReadThrough="1.55031" /MaxDrop="8.31576" /score="36.3638154" /energy="-12.3" /TU="NA" /idTUdmin="U868" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1106081..1106668) /gene="yisN" /locus_tag="BSU_10780" /old_locus_tag="BSU10780" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388959.1" /db_xref="EnsemblGenomes-Gn:BSU10780" /db_xref="EnsemblGenomes-Tr:CAB12918" /db_xref="InterPro:IPR024488" /db_xref="SubtiList:BG12239" /db_xref="UniProtKB/Swiss-Prot:O06727" /translation="MKKKETAWMKRKQLLYTEERKWEYGTILIEDGICLIENGEGDIL LADSLQHSPIWIHHKGKWEQAGFQDKLVLACGAENISLSGGERIRYEKSVKRPLMALL DSLDDETFLAFLQHLHSFGLSVFDCVFSYNKGVFSNTSAGQGVSFYHFSNDTAQCAMQ HHYNYSSEGTGDRFEWTASNGKRSIMYTAVQRGRK*" /label="yisN CDS" gene complement(1106081..1106668) /gene="yisN" /locus_tag="BSU_10780" /old_locus_tag="BSU10780" /label="yisN gene" promotor_-10 complement(1106683..1106702) /Source="Nicolas_upshift_promotors" /id="U869" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.561438561438561" /psig="0.561438561438561" /xcortree=1023 /SigmaFactorBS="caccttagtaagtttatgcatctataggcagatagttgattt GTCcataaaagagttgtaTGGGACAGGCTTGAATTGGAaagaaaagagaggaatgaag a" /listShort="yisN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1106702) /Source="Nicolas_upshifts" /id="U869" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.561438561438561" /psig="0.561438561438561" /xcortree=1023 /SigmaFactorBS="caccttagtaagtttatgcatctataggcagatagttgattt GTCcataaaagagttgtaTGGGACAGGCTTGAATTGGAaagaaaagagaggaatgaag a" /listShort="yisN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1106718..1106720) /Source="Nicolas_upshift_promotors" /id="U869" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.561438561438561" /psig="0.561438561438561" /xcortree=1023 /SigmaFactorBS="caccttagtaagtttatgcatctataggcagatagttgattt GTCcataaaagagttgtaTGGGACAGGCTTGAATTGGAaagaaaagagaggaatgaag a" /listShort="yisN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1106723..1106729 /Source="Nicolas_upshift_promotors" /id="U870" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.543456543456543" /psig="0.543456543456543" /xcortree=1061 /SigmaFactorBS="tttccaattcaagcctgtcccatacaactcttttatggacaa ATCAACTatctgcctatagatGCATAAACTTACTAAGGTGctgaaagaaacgaaattg t" /listShort="S387, asnO, S388" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1106741 /Source="Nicolas_upshifts" /id="U870" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.543456543456543" /psig="0.543456543456543" /xcortree=1061 /SigmaFactorBS="tttccaattcaagcctgtcccatacaactcttttatggacaa ATCAACTatctgcctatagatGCATAAACTTACTAAGGTGctgaaagaaacgaaattg t" /listShort="S387, asnO, S388" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1106744..1106762 /Source="Nicolas_upshift_promotors" /id="U870" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.543456543456543" /psig="0.543456543456543" /xcortree=1061 /SigmaFactorBS="tttccaattcaagcctgtcccatacaactcttttatggacaa ATCAACTatctgcctatagatGCATAAACTTACTAAGGTGctgaaagaaacgaaattg t" /listShort="S387, asnO, S388" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1106747..1106813 /Source="Nicolas_S_feature" /locus_tag="new_1157170_1157236" /HighExp="S6, S5, S7, S8, B36, S4, BT, G/S, B60, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.543" /TUlongSig="NA" /TUlongPSig="NA" /label="S387" CDS 1106814..1108658 /gene="asnO" /locus_tag="BSU_10790" /old_locus_tag="BSU10790" /EC_number="6.3.5.4" /function="16.5: Explore" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10498721, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10498721, 26735940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="asparagine synthetase (sporulation related)" /protein_id="NP_388960.2" /db_xref="EnsemblGenomes-Gn:BSU10790" /db_xref="EnsemblGenomes-Tr:CAB12919" /db_xref="GOA:O05272" /db_xref="InterPro:IPR001962" /db_xref="InterPro:IPR006426" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR017932" /db_xref="InterPro:IPR029055" /db_xref="InterPro:IPR033738" /db_xref="SubtiList:BG12240" /db_xref="UniProtKB/Swiss-Prot:O05272" /translation="MCGITGWVDFKKQLVQEKQTMDRMTDTLSKRGPDDSNVWGEHHV LFGHKRLAVVDIEGGRQPMACTYKGDTYTIIYNGELYNTEDLRKELRARGHQFERTSD TEVLLHSYIEWQEDCVDHLNGIFAFAVWDEKRNLLFAARDRLGVKPFFYTKEGSSFLF GSEIKAILAHPDIKARVDRTGLSEIFGLGPSRTPGTGIFKGIKEIRPAHALTFSKDGL NIWRYWNVESEKHTDSFDDTVANVRSLFQDAVTRQLVSDVPVCTFLSGGLDSSAITAI AAGHFEKEGKAPLHTYSIDYEENDKYFQASAFQPNDDGPWIEKMTEAFGTTHHKCVIS QKDLVDHLEEAVLVKDLPGMADVDSSLLWFCREIKKDFVVSLSGECADEIFGGYPWFH TADVESGFPWMRSTEERIKLLSDSWQKKLNLKEYVNAKYEETLAETPLLDGETGVDKA RRQLFYLNMLWFMTNLLDRKDRMSMGASLEVRVPFADHRLVEYVWNIPWEMKMHDNRE KGILRKALEGILPDDILYRKKSPYPKTHHPEYTKGVSEWLKTIRSQKDSVLHTLLDRK QLDQLLETEGSSFKVPWFGQLMKGPQLIAHLAQIHTWFEAYRIDIDER*" /label="asnO CDS" gene 1106814..1108658 /gene="asnO" /locus_tag="BSU_10790" /old_locus_tag="BSU10790" /label="asnO gene" S_feature 1108659..1108726 /Source="Nicolas_S_feature" /locus_tag="new_1159082_1159149" /HighExp="S6, S5, S7, B36, BT, S8, S4, B60, S3, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.543" /TUlongSig="NA" /TUlongPSig="NA" /label="S388" downshifts 1108683 /Source="Nicolas_upshifts" /id="D587" /incds=0 /nref=12 /ntot=43 /MaxReadThrough="3.29969" /MaxDrop="4.67478" /score="3.55879494" /energy="-14.8" /TU="U870" /idTUdmin="U870" /TUdmin="-550" /isTUend="FALSE" /label="downshifts" CDS complement(1108788..1109267) /gene="yizA" /locus_tag="BSU_10800" /old_locus_tag="BSU10800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein (sporulation related)" /protein_id="YP_054576.1" /db_xref="EnsemblGenomes-Gn:BSU10800" /db_xref="EnsemblGenomes-Tr:CAE01451" /db_xref="GOA:Q7WY73" /db_xref="InterPro:IPR007837" /db_xref="InterPro:IPR034660" /db_xref="PDB:2QE9" /db_xref="SubtiList:BG14187" /db_xref="UniProtKB/Swiss-Prot:Q7WY73" /translation="MMKFFEYNWQVRDQWFTWCHQLTTEELLKNRLGGVENILYTLFH IIDVEYSWIRAIQGKEDIAVQFADYQTLNKVKSLSNTFRTEIIDVLQTHSDQIKDELV SVPWETGVLYTRDEILHHIIAHEIHHIGQLSVWARELKLSPVSASFIGRTLKPIHSY* " /label="yizA CDS" gene complement(1108788..1109267) /gene="yizA" /locus_tag="BSU_10800" /old_locus_tag="BSU10800" /label="yizA gene" upshifts complement(1109287) /Source="Nicolas_upshifts" /id="U871" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.701298701298701" /psig="0.701298701298701" /xcortree=530 /SigmaFactorBS="caatcatcacttcattaatAGAGGAATCacggaaaaaaGGGC TAATTGTTATGATACatgatagtattggagtgagtttagtgatgaaattttttgaata t" /listShort="yizA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1109291..1109309) /Source="Nicolas_upshift_promotors" /id="U871" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.701298701298701" /psig="0.701298701298701" /xcortree=530 /SigmaFactorBS="caatcatcacttcattaatAGAGGAATCacggaaaaaaGGGC TAATTGTTATGATACatgatagtattggagtgagtttagtgatgaaattttttgaata t" /listShort="yizA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1109320..1109328) /Source="Nicolas_upshift_promotors" /id="U871" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.701298701298701" /psig="0.701298701298701" /xcortree=530 /SigmaFactorBS="caatcatcacttcattaatAGAGGAATCacggaaaaaaGGGC TAATTGTTATGATACatgatagtattggagtgagtttagtgatgaaattttttgaata t" /listShort="yizA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1109459..1109463 /Source="Nicolas_upshift_promotors" /id="U872" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.338661338661339" /psig="0.988011988011988" /xcortree=2373 /SigmaFactorBS="tgcgtcttgttacttttacaaagtaagaatcggcattttctt cATATAcaattaggaaaaaaCATACTAGACTTGAAGAAGCagtgatacataggagtga g" /listShort="yisP" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1109476 /Source="Nicolas_upshifts" /id="U872" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.338661338661339" /psig="0.988011988011988" /xcortree=2373 /SigmaFactorBS="tgcgtcttgttacttttacaaagtaagaatcggcattttctt cATATAcaattaggaaaaaaCATACTAGACTTGAAGAAGCagtgatacataggagtga g" /listShort="yisP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1109478..1109497 /Source="Nicolas_upshift_promotors" /id="U872" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.338661338661339" /psig="0.988011988011988" /xcortree=2373 /SigmaFactorBS="tgcgtcttgttacttttacaaagtaagaatcggcattttctt cATATAcaattaggaaaaaaCATACTAGACTTGAAGAAGCagtgatacataggagtga g" /listShort="yisP" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1109499..1110323 /gene="farP" /locus_tag="BSU_10810" /old_locus_tag="BSU10810" /EC_number="3.6.1.27" /experiment="publication(s) with functional evidences, PMID:23295493, 25308276" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23295493, 25308276; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="farnesyl diphosphate phosphatase" /protein_id="NP_388961.1" /db_xref="EnsemblGenomes-Gn:BSU10810" /db_xref="EnsemblGenomes-Tr:CAB12920" /db_xref="GOA:O06728" /db_xref="InterPro:IPR002060" /db_xref="InterPro:IPR008949" /db_xref="PDB:3WE9" /db_xref="SubtiList:BG12241" /db_xref="UniProtKB/Swiss-Prot:O06728" /translation="MIHRSEKMKEIKEAYQQCGQIVGEYAPACFKALSYLPLKQRQAS WAVLSFCHTAASADEKVLPAFEAKADHVYQRTNNGKQHLWKAFDHAYRTFTLESEPFR EFIAAQKEDAKPYDDLDELLMYAYRTGGAAGLMLLPILTRRKQDQLKQAAVSLGLAIQ LVRFLSDLGTDQQKNRIPRQVMQQFGYTEADLQKGTVNKAFTMTWEYIAFEAEAYLEE CQDALPLFPQYSQKTVKAALHLHRAVLEKIRAKQHDVFQYHFALTETEVKQILSDI*" /label="farP CDS" gene 1109499..1110323 /gene="farP" /locus_tag="BSU_10810" /old_locus_tag="BSU10810" /label="farP gene" promotor_-35 1109711..1109717 /Source="Nicolas_upshift_promotors" /id="U873" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=261 /SigmaFactorBS="gtattgcccgcatttgaagctaaagctgatcaTGTTTACcaa aggacaaataaCGGTAAACAACATCTATGGaaggcttttgatcatgcgtatcggacct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1109732..1109750 /Source="Nicolas_upshift_promotors" /id="U873" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=261 /SigmaFactorBS="gtattgcccgcatttgaagctaaagctgatcaTGTTTACcaa aggacaaataaCGGTAAACAACATCTATGGaaggcttttgatcatgcgtatcggacct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1109739 /Source="Nicolas_upshifts" /id="U873" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=261 /SigmaFactorBS="gtattgcccgcatttgaagctaaagctgatcaTGTTTACcaa aggacaaataaCGGTAAACAACATCTATGGaaggcttttgatcatgcgtatcggacct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature 1110333..1111783 /Source="Nicolas_S_feature" /locus_tag="new_1160756_1162206" /HighExp="Salt, Etha, Sw, Cold, G150, G180, G135, LBGtran, Heat, Paraq" /AntisenseName="yisQ" /AntisenseCor="0.19511630802652" /AntisenseRegPval="-2.9" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S389" CDS complement(1110353..1111720) /gene="yisQ" /locus_tag="BSU_10820" /old_locus_tag="BSU10820" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 17114254; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative Na(+)-driven efflux transporter" /protein_id="NP_388962.1" /db_xref="EnsemblGenomes-Gn:BSU10820" /db_xref="EnsemblGenomes-Tr:CAB12921" /db_xref="GOA:O07940" /db_xref="InterPro:IPR002528" /db_xref="SubtiList:BG12242" /db_xref="UniProtKB/Swiss-Prot:O07940" /translation="MKQAVFKSTALKKPADKTFSLFSLTWPIFIEVSLYMFMGNADTL MLSQYSDNSVAAVGVSNQILNLIIVMFSFIATGTTVIISQFLGSRQKKEAMEVAYVSI GANFFISLAISAVVFFAAVPLLHMMGLSDALMPDAKVFLQVVGGLSFIQALIMTFSAI LKSYGYTKDTMFVTIGMNILNIAGNFVVIFGLFGFPVLGVAGVAMSTSIARVIGLIAM IVIVNKRIQLKMSLKKVFHMHKEHLRKLLKIGIPSAGEQLSYNLSQMIVTYFIAIMGA QALTTKVYTQNITMFILLFGTAISQGTQILIGRYIGGKQFDAAYERCMKSLYWALGIA AATSVLMTIFSKDLIGLFTQSPDIIATASLLIAMTIILEPGRSFNVIIINSLRAAGDA KFPVYMAMISMWGIGLPLAYLFGIHLGFGLAGIWISFIADEWVRGILMYRRWRSRIWI QKGMA*" /label="yisQ CDS" gene complement(1110353..1111720) /gene="yisQ" /locus_tag="BSU_10820" /old_locus_tag="BSU10820" /label="yisQ gene" promotor_-35 1111752..1111759 /Source="Nicolas_upshift_promotors" /id="U874" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.993006993006993" /xcortree=2737 /SigmaFactorBS="tctaacccctttcgtaaataaaatcaaCGTTTTAAagtgtac ctccatTTCCTTATAATAAAAAGGGAtagaaacgatacttcttgtaaaaatccgactt a" /listShort="yisR, degA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1111773..1111792 /Source="Nicolas_upshift_promotors" /id="U874" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.993006993006993" /xcortree=2737 /SigmaFactorBS="tctaacccctttcgtaaataaaatcaaCGTTTTAAagtgtac ctccatTTCCTTATAATAAAAAGGGAtagaaacgatacttcttgtaaaaatccgactt a" /listShort="yisR, degA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1111785 /Source="Nicolas_upshifts" /id="U874" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.993006993006993" /xcortree=2737 /SigmaFactorBS="tctaacccctttcgtaaataaaatcaaCGTTTTAAagtgtac ctccatTTCCTTATAATAAAAAGGGAtagaaacgatacttcttgtaaaaatccgactt a" /listShort="yisR, degA" /GFF_Attribute="listLong" /label="upshifts" CDS 1111844..1112707 /gene="yisR" /locus_tag="BSU_10830" /old_locus_tag="BSU10830" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10704478; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (AraC/XylS family)" /protein_id="NP_388963.1" /db_xref="EnsemblGenomes-Gn:BSU10830" /db_xref="EnsemblGenomes-Tr:CAB12922" /db_xref="GOA:P40331" /db_xref="InterPro:IPR003313" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR018060" /db_xref="InterPro:IPR018062" /db_xref="SubtiList:BG11064" /db_xref="UniProtKB/Swiss-Prot:P40331" /translation="MPRILFTVPPFPVFIAAGEGVFKKGETHVKRVFSVFDLIYVKQG TLYITENETSFSVEGGEYILLSPGLEHYGTKGSDEATSYYWLHFDEHRYEFTAKGGSN WSELQQEKGSFEELARYGLALPRKGKVQRPQFMAQQFEKLIDYSAENSDLPLRKQILF EELMLHLQKEAFQIPSAKERVAWEAARYLQEHYKEKTTIKDLSLALHYHQDYVSRCMQ QVLGVTPAQYTNRVRMTEAKRLLSSTNDKMGVIAETVGMEDPTYFSKLFKQIEGISPI EYRKIVSRKVQ*" /label="yisR CDS" gene 1111844..1112707 /gene="yisR" /locus_tag="BSU_10830" /old_locus_tag="BSU10830" /label="yisR gene" CDS 1112725..1113738 /gene="iolQ" /locus_tag="BSU_10840" /old_locus_tag="BSU10840" /function="16.6: Maintain" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8407808, 23504016, 28693424" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8407808, 23504016, 28693424; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of iolX (LacI family)" /protein_id="NP_388964.1" /db_xref="EnsemblGenomes-Gn:BSU10840" /db_xref="EnsemblGenomes-Tr:CAB12923" /db_xref="GOA:P37947" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG10847" /db_xref="UniProtKB/Swiss-Prot:P37947" /translation="MKTTIYDVAKAAGVSITTVSRVINNTGRISDKTRQKVMNVMNEM AYTPNVHAAALTGKRTNMIALVAPDISNPFYGELAKSIEERADELGFQMLICSTDYDP KKETKYFSVLKQKKVDGIIFATGIESHDSMSALEEIASEQIPIAMISQDKPLLPMDIV VIDDVRGGYEAAKHLLSLGHTNIACIIGDGSTTGEKNRIKGFRQAMEEAGVPIDESLI IQTRFSLESGKEEAGKLLDRNAPTAIFAFNDVLACAAIQAARIRGIKVPDDLSIIGFD NTILAEMAAPPLTTVAQPIKEMGRSVIELLAEAIEGKRKAKQKIVLPPELVVRHSTSP LNT*" /label="iolQ CDS" gene 1112725..1113738 /gene="iolQ" /locus_tag="BSU_10840" /old_locus_tag="BSU10840" /label="iolQ gene" downshifts 1113721 /Source="Nicolas_upshifts" /id="D588" /incds=0 /nref=13 /ntot=204 /MaxReadThrough="0.51227" /MaxDrop="3.29173" /score="25.1260914" /energy="-9.6" /TU="NA" /idTUdmin="U874" /TUdmin=22 /isTUend="TRUE" /label="downshifts" promotor_-35 1113790..1113797 /Source="Nicolas_upshift_promotors" /id="U875" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.91008991008991" /psig="0.988011988011988" /xcortree=334 /SigmaFactorBS="agttgaagccaaaaaaacaTATTGCGTgtaaaccaaaggcgG TGTAAAATATAACCATCTTttgagaaagcgcttgcgcaaaatggcagagcggatagaa c" /listShort="S390, yisS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1113812..1113831 /Source="Nicolas_upshift_promotors" /id="U875" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.91008991008991" /psig="0.988011988011988" /xcortree=334 /SigmaFactorBS="agttgaagccaaaaaaacaTATTGCGTgtaaaccaaaggcgG TGTAAAATATAACCATCTTttgagaaagcgcttgcgcaaaatggcagagcggatagaa c" /listShort="S390, yisS" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1113831..1113946 /Source="Nicolas_S_feature" /locus_tag="new_1164254_1164369" /HighExp="Lbstat, M40t90, M0t90, BI, G150, dia0, Mt0, Lbexp, Lbtran, dia5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S390" upshifts 1113831 /Source="Nicolas_upshifts" /id="U875" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.91008991008991" /psig="0.988011988011988" /xcortree=334 /SigmaFactorBS="agttgaagccaaaaaaacaTATTGCGTgtaaaccaaaggcgG TGTAAAATATAACCATCTTttgagaaagcgcttgcgcaaaatggcagagcggatagaa c" /listShort="S390, yisS" /GFF_Attribute="listLong" /label="upshifts" CDS 1113947..1114975 /gene="iolX" /locus_tag="BSU_10850" /old_locus_tag="BSU10850" /EC_number="1.1.1.370" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11160890, 20133360, 23109554, 23504016, 28693424" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11160890, 20133360, 23109554, 23504016, 28693424; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="scyllo-inositol 2-dehydrogenase (NAD(+))" /protein_id="NP_388965.1" /db_xref="EnsemblGenomes-Gn:BSU10850" /db_xref="EnsemblGenomes-Tr:CAB12924" /db_xref="GOA:P40332" /db_xref="InterPro:IPR000683" /db_xref="InterPro:IPR004104" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11065" /db_xref="UniProtKB/Swiss-Prot:P40332" /translation="MEHQVRCAVLGLGRLGYYHAKNLVTSVPGAKLVCVGDPLKGRAE QVARELGIEKWSEDPYEVLEDPGIDAVIIVTPTSTHGDMIIKAAENGKQIFVEKPLTL SLEESKAASEKVKETGVICQVGFMRRFDPAYADAKRRIDAGEIGKPIYYKGFTRDQGA PPAEFIKHSGGIFIDCSIHDYDIARYLLGAEITSVSGHGRILNNPFMEQYGDVDQALT YIEFDSGAAGDVEASRTSPYGHDIRAEVIGTEGSIFIGTLRHQHVTILSAKGSSFDII PDFQTRFHEAYCLELQHFAECVRNGKTPIVTDIDATINLEVGIAATNSFRNGMPVQLD VKRAYTGM*" /label="iolX CDS" gene 1113947..1114975 /gene="iolX" /locus_tag="BSU_10850" /old_locus_tag="BSU10850" /label="iolX gene" downshifts 1114997 /Source="Nicolas_upshifts" /id="D589" /incds=0 /nref=4 /ntot=37 /MaxReadThrough="0.33001" /MaxDrop="3.45406" /score="8.69111487" /energy="-13.4" /TU="NA" /idTUdmin="U875" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1115026..1115535) /gene="yisT" /locus_tag="BSU_10860" /old_locus_tag="BSU10860" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 25651892; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative enzyme regulator of activity" /protein_id="NP_388966.2" /db_xref="EnsemblGenomes-Gn:BSU10860" /db_xref="EnsemblGenomes-Tr:CAB12925" /db_xref="GOA:O07939" /db_xref="InterPro:IPR007837" /db_xref="InterPro:IPR034660" /db_xref="SubtiList:BG12243" /db_xref="UniProtKB/Swiss-Prot:O07939" /translation="MTDAKQFYDYHSWANKKIFTHIENLPEETAYQEVKSVFPSVSDV LLHMCRADYIWLNVLSGVAYQEIIDSAGKLQSAQGNMAAIKQHAAELESQYHDFFSRQ TDLEQTFTMQHPKLGTLESTYADTILHVVNHGTYHRGNVTAMLRQLDHSGVPTDYMYY LYEKRESKG*" /label="yisT CDS" gene complement(1115026..1115535) /gene="yisT" /locus_tag="BSU_10860" /old_locus_tag="BSU10860" /label="yisT gene" downshifts complement(1115045) /Source="Nicolas_upshifts" /id="D590" /incds=0 /nref=81 /ntot=251 /MaxReadThrough="-0.0416600000000003" /MaxDrop="7.15629" /score="27.2292301" /energy="-13.4" /TU="NA" /idTUdmin="U876" /TUdmin="-16" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1115548..1115566) /Source="Nicolas_upshift_promotors" /id="U876" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=520 /SigmaFactorBS="agcggcaggatattttggggtgtcactcttttgcaattGAAG GAGAAacagatgaaaaAAACGAATTTCTTAGAAAAgggggcatgctgatgactgatgc a" /listShort="yisT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1115564) /Source="Nicolas_upshifts" /id="U876" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=520 /SigmaFactorBS="agcggcaggatattttggggtgtcactcttttgcaattGAAG GAGAAacagatgaaaaAAACGAATTTCTTAGAAAAgggggcatgctgatgactgatgc a" /listShort="yisT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1115578..1115586) /Source="Nicolas_upshift_promotors" /id="U876" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=520 /SigmaFactorBS="agcggcaggatattttggggtgtcactcttttgcaattGAAG GAGAAacagatgaaaaAAACGAATTTCTTAGAAAAgggggcatgctgatgactgatgc a" /listShort="yisT" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1115585..1116247) /gene="yisU" /locus_tag="BSU_10870" /old_locus_tag="BSU10870" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative aminoacid related metabolite efflux transporter" /protein_id="NP_388967.1" /db_xref="EnsemblGenomes-Gn:BSU10870" /db_xref="EnsemblGenomes-Tr:CAB12926" /db_xref="GOA:O06730" /db_xref="InterPro:IPR001123" /db_xref="SubtiList:BG13100" /db_xref="UniProtKB/Swiss-Prot:O06730" /translation="MTISLMIEKKCERSFFSMNAIIHGIVLAFGLILPLGVQNVFIFQ QGALQKHIWRALPAVISASVCDTLLIVLAVAGVSVIVQELPVFETVMMAGGFLFLLYM GWVTWNIRPNTSQNEKHTFTPKKQAAFAAAVSLLNPHAILDTIGVIGTSSLQYSGLEK WLFMAACIAVSWIWFISLAIAGRLFQTIDTSGRLMLIVNKCSAAVMWAAAGYFGVSLF CN*" /label="yisU CDS" gene complement(1115585..1116247) /gene="yisU" /locus_tag="BSU_10870" /old_locus_tag="BSU10870" /label="yisU gene" promotor_-35 1116266..1116272 /Source="Nicolas_upshift_promotors" /id="U877" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.5004995004995" /psig=1 /xcortree=3135 /SigmaFactorBS="gagagattgtcactaaagtctccagccatttGGTTGGGttag gaaccagccAAATGTATAATGTGTAAAAAaggggggcatgaccttgtcgcaatggcag c" /listShort="yisV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1116286..1116305 /Source="Nicolas_upshift_promotors" /id="U877" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.5004995004995" /psig=1 /xcortree=3135 /SigmaFactorBS="gagagattgtcactaaagtctccagccatttGGTTGGGttag gaaccagccAAATGTATAATGTGTAAAAAaggggggcatgaccttgtcgcaatggcag c" /listShort="yisV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1116295 /Source="Nicolas_upshifts" /id="U877" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.5004995004995" /psig=1 /xcortree=3135 /SigmaFactorBS="gagagattgtcactaaagtctccagccatttGGTTGGGttag gaaccagccAAATGTATAATGTGTAAAAAaggggggcatgaccttgtcgcaatggcag c" /listShort="yisV" /GFF_Attribute="listLong" /label="upshifts" CDS 1116314..1117768 /gene="yisV" /locus_tag="BSU_10880" /old_locus_tag="BSU10880" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15223311, 19383706; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative PLP-dependent transcriptional regulator" /protein_id="NP_388968.2" /db_xref="EnsemblGenomes-Gn:BSU10880" /db_xref="EnsemblGenomes-Tr:CAB12927" /db_xref="GOA:Q796Q6" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13101" /db_xref="UniProtKB/Swiss-Prot:Q796Q6" /translation="MTLSQWQPSRKSDVPLHRQIEQYMKDKILHGEWAVGTKIPSQRT LADMFQVNRSTVTAAIDELTSQGLLEGRKGGGTKVVNSTWSVLTAEPPLDWSDYVRSG IHRANSSIIQAINQNEPRADIIRLGTGELSPDLVPADTIGRMFQQINPGVLSLGYEQP KGNRQLREAVADHLKGKKIHVSPSAILIVSGALQALQLISIGLLKRDSVILTEKPSYL QSLHVFQSAGMRLRGLPMDDEGVKAGLVSSNRKQYGGQLLYTIPSFHNPTGTVMSEQR RKEIISLSKKEQMPIIEDDAYGDLWFEEKPPQPLKAMDHEGNILYLGAFSKTVSPGLR IGWLAGPEPVIERLADIKMQTDYGSSGLSQWAAAEWLSQGYYEEHLTWVRRKLKERRD AAVHFLERYAGDIATWRIPAGGFYIWVTFHKNLPVSRFFYELLKRQVLVNPGYIYDGE DRNSIRLSYSYASLGDLETGIKAAAETARRLMMS*" /label="yisV CDS" gene 1116314..1117768 /gene="yisV" /locus_tag="BSU_10880" /old_locus_tag="BSU10880" /label="yisV gene" S_feature complement(1117623..1117775) /Source="Nicolas_S_feature" /locus_tag="new_1168046_1168198_c" /HighExp="Diami, Sw, C90, LBGstat, dia15, Paraq, dia5, BC, M40t45, Oxctl" /AntisenseName="yisV" /AntisenseCor="0.69858995161852" /AntisenseRegPval="-40" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S391" downshifts complement(1117658) /Source="Nicolas_upshifts" /id="D591" /incds=1 /nref=2 /ntot=84 /MaxReadThrough="2.36735" /MaxDrop="2.81041" /score="-5.131548" /energy="-17.3" /TU="NA" /idTUdmin="U879" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" CDS complement(1117776..1118414) /gene="yisX" /locus_tag="BSU_10890" /old_locus_tag="BSU10890" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388970.1" /db_xref="EnsemblGenomes-Gn:BSU10890" /db_xref="EnsemblGenomes-Tr:CAB12929" /db_xref="InterPro:IPR001646" /db_xref="SubtiList:BG13103" /db_xref="UniProtKB/Swiss-Prot:O06733" /translation="MNKIAIQKPNIPENLQTADFHDAVTQDDVISMHLFEDCTICGED IERLCVEKTVFRNVVFIDVSFRHIELTDVIFEKCDLSNADFSGAVIHRTSVKQSKMVG MNVAEATLRNVSFEECHGHFSSFSYSNMKQVRFDHCALMQSECSDTVLQQTHFDGCEL EGASFTGTSLQNMDISTCRFEQLHVSLDKLKGCKIAPEHAIAFARALGAVIV*" /label="yisX CDS" gene complement(1117776..1118414) /gene="yisX" /locus_tag="BSU_10890" /old_locus_tag="BSU10890" /label="yisX gene" S_feature complement(1118415..1118549) /Source="Nicolas_S_feature" /locus_tag="new_1168838_1168972_c" /HighExp="Diami, dia15, dia5, C90, BC, Paraq, LBGstat, Lbtran, HiOs, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S392" promotor_-35 1118463..1118468 /Source="Nicolas_upshift_promotors" /id="U878" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1110 /SigmaFactorBS="cctttgctgcccgaaaaacagaggcttccgggttcaatTTAA TAgatcgttaaggaaatTGATACATATAGTAAATCGtgaagagccttttcttggtaca g" /listShort="S393, yisY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1118484..1118502 /Source="Nicolas_upshift_promotors" /id="U878" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1110 /SigmaFactorBS="cctttgctgcccgaaaaacagaggcttccgggttcaatTTAA TAgatcgttaaggaaatTGATACATATAGTAAATCGtgaagagccttttcttggtaca g" /listShort="S393, yisY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1118485 /Source="Nicolas_upshifts" /id="U878" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1110 /SigmaFactorBS="cctttgctgcccgaaaaacagaggcttccgggttcaatTTAA TAgatcgttaaggaaatTGATACATATAGTAAATCGtgaagagccttttcttggtaca g" /listShort="S393, yisY" /GFF_Attribute="listLong" /label="upshifts" S_feature 1118495..1118619 /Source="Nicolas_S_feature" /locus_tag="new_1168918_1169042" /HighExp="S6, S5, S8, S7, S4, BT, B36, S3, G/S, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S393" promotor_-10 complement(1118535..1118554) /Source="Nicolas_upshift_promotors" /id="U879" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig="0.995004995004995" /xcortree=2078 /SigmaFactorBS="tcctgttccctttggctttttcggcctgtaaacGCCTTGACg tataggaagctttCCATTTATGCTTACAAAACAagcgggctgctgtaccaagaaaagg c" /listShort="S392, yisX, S391" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1118549) /Source="Nicolas_upshifts" /id="U879" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig="0.995004995004995" /xcortree=2078 /SigmaFactorBS="tcctgttccctttggctttttcggcctgtaaacGCCTTGACg tataggaagctttCCATTTATGCTTACAAAACAagcgggctgctgtaccaagaaaagg c" /listShort="S392, yisX, S391" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1118569..1118576) /Source="Nicolas_upshift_promotors" /id="U879" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig="0.995004995004995" /xcortree=2078 /SigmaFactorBS="tcctgttccctttggctttttcggcctgtaaacGCCTTGACg tataggaagctttCCATTTATGCTTACAAAACAagcgggctgctgtaccaagaaaagg c" /listShort="S392, yisX, S391" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1118620..1119426 /gene="yisY" /locus_tag="BSU_10900" /old_locus_tag="BSU10900" /EC_number="3.1.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22882546, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyl hydrolase or peroxidase" /protein_id="NP_388971.1" /db_xref="EnsemblGenomes-Gn:BSU10900" /db_xref="EnsemblGenomes-Tr:CAB12930" /db_xref="GOA:O06734" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR000639" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG13104" /db_xref="UniProtKB/Swiss-Prot:O06734" /translation="MGHYIKTEEHVTLFVEDIGHGRPIIFLHGWPLNHKMFEYQMNEL PKRGFRFIGVDLRGYGQSDRPWEGYDYDTMADDVKAVIYTLQLENAILAGFSMGGAIA IRYMARHEGADVDKLILLSAAAPAFTKRPGYPYGMRKQDIDDMIELFKADRPKTLADL GKQFFEKKVSPELRQWFLNLMLEASSYGTIHSGIALRDEDLRKELAAIKVPTLILHGR KDRIAPFDFAKELKRGIKQSELVPFANSGHGAFYEEKEKINSLIAQFSNS*" /label="yisY CDS" gene 1118620..1119426 /gene="yisY" /locus_tag="BSU_10900" /old_locus_tag="BSU10900" /label="yisY gene" downshifts 1119419 /Source="Nicolas_upshifts" /id="D592" /incds=0 /nref=4 /ntot=24 /MaxReadThrough="2.64682" /MaxDrop="5.60718" /score="8.70914085" /energy="-6.5" /TU="NA" /idTUdmin="U878" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1119454..1120053) /gene="yisZ" /locus_tag="BSU_10910" /old_locus_tag="BSU10910" /EC_number="2.7.1.25" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15383836; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative adenylylsulfate kinase" /protein_id="NP_388972.1" /db_xref="EnsemblGenomes-Gn:BSU10910" /db_xref="EnsemblGenomes-Tr:CAB12931" /db_xref="GOA:O06735" /db_xref="InterPro:IPR002891" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13105" /db_xref="UniProtKB/Swiss-Prot:O06735" /translation="MTHNPNIIWHPAAISKSDRQSLNGHKSCVLWFTGLSGSGKSVLA NAVDEKLYRKGIQSYVLDGDNIRHGLNKDLGFQTGDRIENIRRIGEVAKLFVDSGQMI LTAFISPFREDRDMVRALFPKGEFFEIYVKCPLHVCEQRDPKGLYKKARNGEIKHFTG IDSPYEAPLSPDFIIESDQTSISDGADLIINALQNRGII*" /label="yisZ CDS" gene complement(1119454..1120053) /gene="yisZ" /locus_tag="BSU_10910" /old_locus_tag="BSU10910" /label="yisZ gene" downshifts complement(1119473) /Source="Nicolas_upshifts" /id="D593" /incds=0 /nref=35 /ntot=44 /MaxReadThrough="1.69999" /MaxDrop="6.8011" /score="17.1506785" /energy="-7.3" /TU="NA" /idTUdmin="U880" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1120050..1121219) /gene="yitA" /locus_tag="BSU_10920" /old_locus_tag="BSU10920" /EC_number="2.7.7.4" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15383836; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sulfate adenylyltransferase" /protein_id="NP_388973.2" /db_xref="EnsemblGenomes-Gn:BSU10920" /db_xref="EnsemblGenomes-Tr:CAB12932" /db_xref="GOA:O06736" /db_xref="InterPro:IPR002650" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR020792" /db_xref="InterPro:IPR024951" /db_xref="InterPro:IPR025980" /db_xref="SubtiList:BG13106" /db_xref="UniProtKB/Swiss-Prot:O06736" /translation="MNGNEPHGGVLINRCDPACHFEGCACQAELDQLALSDLELIAIG GYSPLTGFLGEKDYHSVVKEMRLANGLPWSLPITLPVGEKTARQLSAGDHVKLVKDGV TYGMITVTDIYQPDKTQEALSVFKTNDPAHPGVKKLLARPDYYIGGPITVSSLPDKSF EQFYATPAETRAAFQKLGWKTIVGFQTRNPVHRAHEYIQKTALETVDGLLLHPLVGET KSDDIPSDIRMESYQALLNHYYPKDRVMLSVFPAAMRYAGPREAIFHALVRKNYGCTH FIVGRDHAGVGSYYGTYDAQNIFQSFTEEELGIKPLFFEHSFYCRKCGNMGTSKTCPH SPRDHIHLSGTKVRELLRQGKKPPKEFSRPEVAAVLIKGLHQQPVAIKQNSGELQ*" /label="yitA CDS" gene complement(1120050..1121219) /gene="yitA" /locus_tag="BSU_10920" /old_locus_tag="BSU10920" /label="yitA gene" S_feature complement(1121220..1121331) /Source="Nicolas_S_feature" /locus_tag="new_1171643_1171754_c" /HighExp="S6, S7, S8, BT, S5, B36, G/S, Pyr, SMMPr, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S394" CDS complement(1121332..1122042) /gene="yitB" /locus_tag="BSU_10930" /old_locus_tag="BSU10930" /EC_number="1.8.4.8" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15383836; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phospho-adenylylsulfate reductase" /protein_id="NP_388974.2" /db_xref="EnsemblGenomes-Gn:BSU10930" /db_xref="EnsemblGenomes-Tr:CAB12933" /db_xref="GOA:O06737" /db_xref="InterPro:IPR002500" /db_xref="InterPro:IPR004511" /db_xref="InterPro:IPR011798" /db_xref="InterPro:IPR014729" /db_xref="SubtiList:BG13107" /db_xref="UniProtKB/Swiss-Prot:O06737" /translation="MNETITYDTWNDMLSKQITDQLIDELDVLKWAYRTYGEKIVYAC SFGAEGMVLLDLISKINKNAHIIFLDTGLHFQETYELIETVKERYPGFAIQMLEPELS LTEQGTKYGGELWKHNPNLCCQLRKIEPLKKHLSGMTAWISGLRRDQSPTRKHIQYVN LDQKFELIKICPLIHWTWDDVWTYIRLHNLPYNKLHDQHYPSIGCEMCTLPSPDPNDE RAGRWAGREKTECGLHQE*" /label="yitB CDS" gene complement(1121332..1122042) /gene="yitB" /locus_tag="BSU_10930" /old_locus_tag="BSU10930" /label="yitB gene" promotor_-10 complement(1122086..1122105) /Source="Nicolas_upshift_promotors" /id="U880" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1285 /SigmaFactorBS="aatggttccgcacctcattttaggcgggcgcggcacctaaaA CCTGAACCTttatgcaaaaaaTGAATAGTCTGCCTATAACTcgatcaatagataaaaa a" /listShort="yitB, S394, yitA, yisZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1122108) /Source="Nicolas_upshifts" /id="U880" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1285 /SigmaFactorBS="aatggttccgcacctcattttaggcgggcgcggcacctaaaA CCTGAACCTttatgcaaaaaaTGAATAGTCTGCCTATAACTcgatcaatagataaaaa a" /listShort="yitB, S394, yitA, yisZ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1122118..1122127) /Source="Nicolas_upshift_promotors" /id="U880" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1285 /SigmaFactorBS="aatggttccgcacctcattttaggcgggcgcggcacctaaaA CCTGAACCTttatgcaaaaaaTGAATAGTCTGCCTATAACTcgatcaatagataaaaa a" /listShort="yitB, S394, yitA, yisZ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1122157..1122166 /Source="Nicolas_upshift_promotors" /id="U881" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1286 /SigmaFactorBS="aggtgccgcgcccgcctaaaatgaggTGCGGAACCAttaaga gcccggcTGAATATGCTTTTTAGCAAAatggttttatgcccaaggagaggtagtatgc c" /listShort="yitC, yitD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1122180..1122199 /Source="Nicolas_upshift_promotors" /id="U881" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1286 /SigmaFactorBS="aggtgccgcgcccgcctaaaatgaggTGCGGAACCAttaaga gcccggcTGAATATGCTTTTTAGCAAAatggttttatgcccaaggagaggtagtatgc c" /listShort="yitC, yitD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1122191 /Source="Nicolas_upshifts" /id="U881" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1286 /SigmaFactorBS="aggtgccgcgcccgcctaaaatgaggTGCGGAACCAttaaga gcccggcTGAATATGCTTTTTAGCAAAatggttttatgcccaaggagaggtagtatgc c" /listShort="yitC, yitD" /GFF_Attribute="listLong" /label="upshifts" CDS 1122227..1122913 /gene="slpH" /locus_tag="BSU_10940" /old_locus_tag="BSU10940" /EC_number="3.1.3.71" /function="15.7: Sporulation and germination" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 3346220, 11830598, 15383836, 16341843; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-phospho,3-sulfolactate phosphatase (sporulation related)" /protein_id="NP_388975.1" /db_xref="EnsemblGenomes-Gn:BSU10940" /db_xref="EnsemblGenomes-Tr:CAB12934" /db_xref="GOA:O06738" /db_xref="InterPro:IPR005238" /db_xref="InterPro:IPR036702" /db_xref="SubtiList:BG13108" /db_xref="UniProtKB/Swiss-Prot:O06738" /translation="MPIAIYQGHHHSLAPADINIVIDVIRAFTVAHYAFIGGAKEILL VRTADEAFALKDTYPDYVLTGEEKGVGISGFDLDNSPKRMAGQNMTDKSLIQKTTNGV TAALGALNAKHLFVTGFSNAKTTAQHVKKLVANDCVINIVASHPSGDDDMACAEYIKG IIEGTNVVTAAEAIERIKGSSVAEKFFDCRQPLFDSEDIVYCTKELTGDFVMKVKQDG EVPTIERVII*" /label="slpH CDS" gene 1122227..1122913 /gene="slpH" /locus_tag="BSU_10940" /old_locus_tag="BSU10940" /label="slpH gene" CDS 1122910..1123668 /gene="slpS" /locus_tag="BSU_10950" /old_locus_tag="BSU10950" /EC_number="4.4.1.19" /function="16.14: Store" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 11830598, 15014443, 15383836; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-phospho-3-sulfolactate synthase" /protein_id="NP_388976.1" /db_xref="EnsemblGenomes-Gn:BSU10950" /db_xref="EnsemblGenomes-Tr:CAB12935" /db_xref="GOA:O06739" /db_xref="InterPro:IPR003830" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR036112" /db_xref="PDB:1U83" /db_xref="SubtiList:BG13109" /db_xref="UniProtKB/Swiss-Prot:O06739" /translation="MNDFSLELPVRTNKPRETGQSILIDNGYPLQFFKDAIAGASDYI DFVKFGWGTSLLTKDLEEKISTLKEHDITFFFGGTLFEKYVSQKKVNEFHRYCTYFGC EYIEISNGTLPMTNKEKAAYIADFSDEFLVLSEVGSKDAELASRQSSEEWLEYIVEDM EAGAEKVITEARESGTGGICSSSGDVRFQIVDDIISSDIDINRLIFEAPNKTLQQGFI QKIGPNVNLANIPFHDAIALETLRLGLRSDTFFL*" /label="slpS CDS" gene 1122910..1123668 /gene="slpS" /locus_tag="BSU_10950" /old_locus_tag="BSU10950" /label="slpS gene" downshifts 1123665 /Source="Nicolas_upshifts" /id="D594" /incds=0 /nref=2 /ntot=20 /MaxReadThrough="2.37654" /MaxDrop="4.17689" /score="-1.32868938" /energy="-17.6" /TU="NA" /idTUdmin="U881" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1123713..1124342) /gene="yitE" /locus_tag="BSU_10960" /old_locus_tag="BSU10960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 26335199; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_388977.1" /db_xref="EnsemblGenomes-Gn:BSU10960" /db_xref="EnsemblGenomes-Tr:CAB12936" /db_xref="GOA:O06740" /db_xref="InterPro:IPR003740" /db_xref="SubtiList:BG13110" /db_xref="UniProtKB/Swiss-Prot:O06740" /translation="MAELLMKAKLTFMIVVGGVLQGLGMSLFLFPHDIPTGGAAGIAV LLHYLFQIPHGFSVWAVNVSMLFTALKWLEMRTFTGTLASITVTSVSVLIFDAVFPDI TSNLWLDLASGAVLLGLGIGLLYKYKISNGGFGALALMISIYRGGNPGTILLIMNCII FMVTASIIDWGIVIQALICQVISTRVIDFIYNIRLTSLPYLTPMYRHKK*" /label="yitE CDS" gene complement(1123713..1124342) /gene="yitE" /locus_tag="BSU_10960" /old_locus_tag="BSU10960" /label="yitE gene" promotor_-10 complement(1124376..1124394) /Source="Nicolas_upshift_promotors" /id="U882" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=996 /SigmaFactorBS="tggctcagcctattaagctgggccatttctttattttgaGAC ATAaataatggacagccTCATAAAATGAAAACAGCGgacaagtcttttcataaaggag c" /listShort="yitE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1124393) /Source="Nicolas_upshifts" /id="U882" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=996 /SigmaFactorBS="tggctcagcctattaagctgggccatttctttattttgaGAC ATAaataatggacagccTCATAAAATGAAAACAGCGgacaagtcttttcataaaggag c" /listShort="yitE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1124409..1124414) /Source="Nicolas_upshift_promotors" /id="U882" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=996 /SigmaFactorBS="tggctcagcctattaagctgggccatttctttattttgaGAC ATAaataatggacagccTCATAAAATGAAAACAGCGgacaagtcttttcataaaggag c" /listShort="yitE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1124438..1125553) /gene="yitF" /locus_tag="BSU_10970" /old_locus_tag="BSU10970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10960106, 11747447, 27994575; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enolase superfamily enzyme (isomerase /dehydratase)" /protein_id="NP_388978.1" /db_xref="EnsemblGenomes-Gn:BSU10970" /db_xref="EnsemblGenomes-Tr:CAB12937" /db_xref="GOA:O06741" /db_xref="InterPro:IPR013341" /db_xref="InterPro:IPR013342" /db_xref="InterPro:IPR029017" /db_xref="InterPro:IPR029065" /db_xref="InterPro:IPR036849" /db_xref="PDB:2GDQ" /db_xref="PDB:2GGE" /db_xref="SubtiList:BG13111" /db_xref="UniProtKB/Swiss-Prot:O06741" /translation="MKIVRIETFPLFHRLEKPYGDANGFKRYRTCYLIRIITESGIDG WGECVDWLPALHVGFTKRIIPFLLGKQAGSRLSLVRTIQKWHQRAASAVSMALTEIAA KAADCSVCELWGGRYREEIPVYASFQSYSDSPQWISRSVSNVEAQLKKGFEQIKVKIG GTSFKEDVRHINALQHTAGSSITMILDANQSYDAAAAFKWERYFSEWTNIGWLEEPLP FDQPQDYAMLRSRLSVPVAGGENMKGPAQYVPLLSQRCLDIIQPDVMHVNGIDEFRDC LQLARYFGVRASAHAYDGSLSRLYALFAQACLPPWSKMKNDHIEPIEWDVMENPFTDL VSLQPSKGMVHIPKGKGIGTEINMEIVNRYKWDGSAY*" /label="yitF CDS" gene complement(1124438..1125553) /gene="yitF" /locus_tag="BSU_10970" /old_locus_tag="BSU10970" /label="yitF gene" downshifts complement(1124467) /Source="Nicolas_upshifts" /id="D595" /incds=0 /nref=11 /ntot=42 /MaxReadThrough="1.81817" /MaxDrop="4.27426" /score="13.5713023" /energy="-14.5" /TU="NA" /idTUdmin="U883" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1125562..1126830) /gene="yitG" /locus_tag="BSU_10980" /old_locus_tag="BSU10980" /function="16.8: Protect" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10960106, 14762009, 15109717, 15849754, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_388979.1" /db_xref="EnsemblGenomes-Gn:BSU10980" /db_xref="EnsemblGenomes-Tr:CAB12938" /db_xref="GOA:Q796Q1" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13112" /db_xref="UniProtKB/Swiss-Prot:Q796Q1" /translation="MESSKQNNGMTIVAIGSIPLILTLGNSMLIPILPKMKSELHLSQ FQVSLVITVFSLIAAFAIPIVGYLADRFSRKVIIIPCLILYGAGGLLAGFAAGFFDNA YPWVMAGRALQGIGAAGTGPIAMALTGDLFKGAQESKVLGLVEASNGMGKVLSPIIGS LIALLVWYGAFFAFPVFCIISIVLTWIFIKEKKKEKEPPPIGQYAKGLLSVFKHEGRW LFTAYLAGATCLFTLFGILFYLSDVLEKTYDTDGVKKGLILAIPLLVMCVTSYTTGSK IGQKQSLMKKLIVLGLAFMTVSYAALSFIENLVLFISVLVLSSIGSGLVLPCVNSFIT GAVGKERRGFVTSLYGSVRFLGVAIGPPIFGRLMQWSRPGMFLSIAGLTLVVGILVMM LIHVKQNNEETKEKEDPKMAGNRLQPAEER*" /label="yitG CDS" gene complement(1125562..1126830) /gene="yitG" /locus_tag="BSU_10980" /old_locus_tag="BSU10980" /label="yitG gene" promotor_-10 complement(1126856..1126867) /Source="Nicolas_upshift_promotors" /id="U883" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=932 /SigmaFactorBS="acaggtatcttctgttcggttttttgctgtctgatcgcTGAA TAAacgaagccatcagGGACATTCTAAGcagaagaaaaggagtgtgctctgagatgga a" /listShort="yitG, yitF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1126865) /Source="Nicolas_upshifts" /id="U883" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=932 /SigmaFactorBS="acaggtatcttctgttcggttttttgctgtctgatcgcTGAA TAAacgaagccatcagGGACATTCTAAGcagaagaaaaggagtgtgctctgagatgga a" /listShort="yitG, yitF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1126881..1126887) /Source="Nicolas_upshift_promotors" /id="U883" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=932 /SigmaFactorBS="acaggtatcttctgttcggttttttgctgtctgatcgcTGAA TAAacgaagccatcagGGACATTCTAAGcagaagaaaaggagtgtgctctgagatgga a" /listShort="yitG, yitF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1126942..1127790) /gene="yitH" /locus_tag="BSU_10990" /old_locus_tag="BSU10990" /EC_number="2.3.1.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_388980.1" /db_xref="EnsemblGenomes-Gn:BSU10990" /db_xref="EnsemblGenomes-Tr:CAB12939" /db_xref="GOA:O06743" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13113" /db_xref="UniProtKB/Swiss-Prot:O06743" /translation="MDVVDELIKLHEEHVSGLLRLCGQAGWPDYGEQELKLLVQQGRF FGYQNVSGDIISCIGLFLFGRLTSIGLVIVDKEYQRLGLGRRMVNACITQTDENTAIR LCATKEGLPLYEKAGFHTAGSVRKYSCHSFQPYTKKLDAELTSFREQDFHDLTAADLA AFGGDRSNLLQQLISASCECIIARNQDGQLIGYGLSVQTPANLKFGPIIAPSSDVAAQ IITRLAAGKQGPMRIDIPSEHTSLHDSLIEMGFHKDDEPPILFYQKKAPIQNGHLYAL ISQALG*" /label="yitH CDS" gene complement(1126942..1127790) /gene="yitH" /locus_tag="BSU_10990" /old_locus_tag="BSU10990" /label="yitH gene" downshifts complement(1126953) /Source="Nicolas_upshifts" /id="D596" /incds=0 /nref=34 /ntot=209 /MaxReadThrough="2.34135" /MaxDrop="3.51892" /score="14.8688564" /energy="-11.7" /TU="NA" /idTUdmin="U884" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1127795..1128244) /gene="yitI" /locus_tag="BSU_11000" /old_locus_tag="BSU11000" /EC_number="2.3.1.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_388981.2" /db_xref="EnsemblGenomes-Gn:BSU11000" /db_xref="EnsemblGenomes-Tr:CAB12940" /db_xref="GOA:O06744" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13114" /db_xref="UniProtKB/Swiss-Prot:O06744" /translation="MLEVKTISVEDTYEIRHRILRPHQSIEQCKYKEDHAEGSFHLGV FYDGTLISIASFSPQSQPLLTEASAYRLRGMATLEGYRDQKAGSTLIKHAEHKLAESG VQAVWCNARHHVKGYYAKLGWKELGEPFDIPGIGNHIVMYKTLRTSR*" /label="yitI CDS" gene complement(1127795..1128244) /gene="yitI" /locus_tag="BSU_11000" /old_locus_tag="BSU11000" /label="yitI gene" promotor_-10 complement(1128265..1128284) /Source="Nicolas_upshift_promotors" /id="U884" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.834165834165834" /psig="0.999000999001" /xcortree=2266 /SigmaFactorBS="cattaatttccaaaagactgcctgatcgaatcgggcagTCtt tttcaacgagattCGTGTTACGATATAGAAAAAcaatcatgaggaggaacattatgct c" /listShort="yitI, yitH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1128279) /Source="Nicolas_upshifts" /id="U884" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.834165834165834" /psig="0.999000999001" /xcortree=2266 /SigmaFactorBS="cattaatttccaaaagactgcctgatcgaatcgggcagTCtt tttcaacgagattCGTGTTACGATATAGAAAAAcaatcatgaggaggaacattatgct c" /listShort="yitI, yitH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1128300..1128301) /Source="Nicolas_upshift_promotors" /id="U884" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.834165834165834" /psig="0.999000999001" /xcortree=2266 /SigmaFactorBS="cattaatttccaaaagactgcctgatcgaatcgggcagTCtt tttcaacgagattCGTGTTACGATATAGAAAAAcaatcatgaggaggaacattatgct c" /listShort="yitI, yitH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1128334..1130172) /gene="samT" /locus_tag="BSU_11010" /old_locus_tag="BSU11010" /EC_number="1.5.1.20" /EC_number="2.1.1.10" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10094622, 17264075, 20421295, 20951706, 26233166; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional homocysteine S-methyltransferase using (R,S)AdoMet and methylenetetrahydrofolate reductase [NAD(P)H]" /protein_id="NP_388982.1" /db_xref="EnsemblGenomes-Gn:BSU11010" /db_xref="EnsemblGenomes-Tr:CAB12941" /db_xref="GOA:O06745" /db_xref="InterPro:IPR003171" /db_xref="InterPro:IPR003726" /db_xref="InterPro:IPR029041" /db_xref="InterPro:IPR036589" /db_xref="SubtiList:BG13115" /db_xref="UniProtKB/Swiss-Prot:O06745" /translation="MGLLEDLQRQVLIGDGAMGTLLYSYGIDRCFEELNISKPEEIQR IHKAYVEAGANIIQTNTYGANYIKLSRHGLEDDIKKMNQEAVKIARASAGDAYVLGTM GGIRTFNKNAYSLDEIKRSFREQLYLLLHEEPDGLLLETYYDLEEAREVLKIARKETD LPIMLNVSMHEQGVLQDGTPLSDALRSIADLGADIVGINCRLGPYHMIEALSEVPIFD DVFLSVYPNSSLPSLEEGRLVYETDDTYFQNSASEFRKQGARIIGGCCGTTPNHIRAM AEAVGGLAPITEKEVKTRAKEFISVHHERTEPGLDEIAAKKRSIIVELDPPKKLSFDK FLSAAAELKEAGIDALTLADNSLATPRISNVACGALVKQQLDMRSLVHITCRDRNIIG LQSHLMGLDTLGLNDVLAITGDPSKIGDFPGATSVYDLTSFDLIRLIKQFNEGLSLSG KPLGKKTNFSVAAAFNPNVRHLDKAVKRLEKKIDCGADYFVSQPVYSEQQLVDIHNET KHLKTPIYIGIMPLTSSRNAEFIHNEIPGIKLSDTIREKMAHAGEDKEKQKAEGLAIA RSLLDTACELFNGIYLITPFLRSDLTAELTSYIQQKDEQRQNIFLH*" /label="samT CDS" gene complement(1128334..1130172) /gene="samT" /locus_tag="BSU_11010" /old_locus_tag="BSU11010" /label="samT gene" downshifts complement(1128361) /Source="Nicolas_upshifts" /id="D597" /incds=0 /nref=14 /ntot=91 /MaxReadThrough="3.04289" /MaxDrop="4.13744" /score="12.9586126" /energy="-16.2" /TU="U885" /idTUdmin="U885" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" downshifts complement(1130254) /Source="Nicolas_upshifts" /id="D598" /incds=0 /nref=47 /ntot=128 /MaxReadThrough="8.00128" /MaxDrop="5.61487" /score="22.3754155" /energy="-7.3" /TU="U885,U887" /idTUdmin="U887" /TUdmin="-1079" /isTUend="FALSE" /label="downshifts" misc_RNA complement(1130262..1130379) /gene="mswK" /locus_tag="BSU_misc_RNA_12" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762; Product type n: RNA" /function="16.3: Control" /label="mswK RNA" gene complement(1130262..1130379) /gene="mswK" /locus_tag="BSU_misc_RNA_12" /label="mswK gene" promotor_-10 complement(1130431..1130450) /Source="Nicolas_upshift_promotors" /id="U885" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig="0.999000999001" /xcortree=2886 /SigmaFactorBS="aatttataaatttcagataaattttctgattccTATTGATTa ttgtctttattttCGGTAAATTTGGAGAAAGGGaaaaacgccagatatcttttggcac t" /listShort="NA, yitJ" /listLong="yitI, yitH" /label="promotor_-10" upshifts complement(1130445) /Source="Nicolas_upshifts" /id="U885" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig="0.999000999001" /xcortree=2886 /SigmaFactorBS="aatttataaatttcagataaattttctgattccTATTGATTa ttgtctttattttCGGTAAATTTGGAGAAAGGGaaaaacgccagatatcttttggcac t" /listShort="NA, yitJ" /listLong="yitI, yitH" /label="upshifts" promotor_-35 complement(1130465..1130472) /Source="Nicolas_upshift_promotors" /id="U885" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig="0.999000999001" /xcortree=2886 /SigmaFactorBS="aatttataaatttcagataaattttctgattccTATTGATTa ttgtctttattttCGGTAAATTTGGAGAAAGGGaaaaacgccagatatcttttggcac t" /listShort="NA, yitJ" /listLong="yitI, yitH" /label="promotor_-35" CDS complement(1130486..1130977) /gene="yitK" /locus_tag="BSU_11020" /old_locus_tag="BSU11020" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12943362, 25329577; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA or cyclic d-GMP binding protein" /protein_id="NP_388983.1" /db_xref="EnsemblGenomes-Gn:BSU11020" /db_xref="EnsemblGenomes-Tr:CAB12942" /db_xref="InterPro:IPR007551" /db_xref="InterPro:IPR035570" /db_xref="InterPro:IPR035571" /db_xref="InterPro:IPR036183" /db_xref="SubtiList:BG13116" /db_xref="UniProtKB/Swiss-Prot:O06746" /translation="MAKESSFDIVSKVELPEVQNAIQIALKEISTRYDFKGSKSDISL DKEELVLVSDDEFKLSQLKDVLVSKLIKRNVPTKNIDYGKVENASGGTVRQRAKLVQG IDKDNAKKINTIIKNSGLKVKSQVQDDQVRVTGKNKDDLQQIISAVRGADLPIDVQFI NFR*" /label="yitK CDS" gene complement(1130486..1130977) /gene="yitK" /locus_tag="BSU_11020" /old_locus_tag="BSU11020" /label="yitK gene" promotor_-35 1130995..1130998 /Source="Nicolas_upshift_promotors" /id="U886" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.555444555444555" /psig="0.997002997002997" /xcortree=2548 /SigmaFactorBS="atcaaatgaactttcttttgccatatgaaaacctccataacA TTTaacttatgtgttgaTTATAGTAGAATAAAGAGAAacttccaacagaacaaagaat c" /listShort="yitL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1131001..1131020) /Source="Nicolas_upshift_promotors" /id="U887" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.851148851148851" /psig=1 /xcortree=3057 /SigmaFactorBS="acattttttccaatcatcacaaattgattctttgttcTGTTG GAAgtttctctttattcTACTATAATCAACACATAAGttaaatgttatggaggttttc a" /listShort="yitK, NA, yitJ" /listLong="yitI, yitH" /label="promotor_-10" promotor_-10 1131013..1131032 /Source="Nicolas_upshift_promotors" /id="U886" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.555444555444555" /psig="0.997002997002997" /xcortree=2548 /SigmaFactorBS="atcaaatgaactttcttttgccatatgaaaacctccataacA TTTaacttatgtgttgaTTATAGTAGAATAAAGAGAAacttccaacagaacaaagaat c" /listShort="yitL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1131014 /Source="Nicolas_upshifts" /id="U886" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.555444555444555" /psig="0.997002997002997" /xcortree=2548 /SigmaFactorBS="atcaaatgaactttcttttgccatatgaaaacctccataacA TTTaacttatgtgttgaTTATAGTAGAATAAAGAGAAacttccaacagaacaaagaat c" /listShort="yitL" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1131019) /Source="Nicolas_upshifts" /id="U887" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.851148851148851" /psig=1 /xcortree=3057 /SigmaFactorBS="acattttttccaatcatcacaaattgattctttgttcTGTTG GAAgtttctctttattcTACTATAATCAACACATAAGttaaatgttatggaggttttc a" /listShort="yitK, NA, yitJ" /listLong="yitI, yitH" /label="upshifts" promotor_-35 complement(1131035..1131042) /Source="Nicolas_upshift_promotors" /id="U887" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.851148851148851" /psig=1 /xcortree=3057 /SigmaFactorBS="acattttttccaatcatcacaaattgattctttgttcTGTTG GAAgtttctctttattcTACTATAATCAACACATAAGttaaatgttatggaggttttc a" /listShort="yitK, NA, yitJ" /listLong="yitI, yitH" /label="promotor_-35" CDS 1131076..1131972 /gene="yitL" /locus_tag="BSU_11030" /old_locus_tag="BSU11030" /function="9.4: RNA processing" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 20399190; Product type f : factor" /codon_start=1 /transl_table=11 /product="RNA-binding protein" /protein_id="NP_388984.1" /db_xref="EnsemblGenomes-Gn:BSU11030" /db_xref="EnsemblGenomes-Tr:CAB12943" /db_xref="GOA:O06747" /db_xref="InterPro:IPR003029" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR014464" /db_xref="InterPro:IPR022967" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG13117" /db_xref="UniProtKB/Swiss-Prot:O06747" /translation="MLTKSAENKRNRKDDSMRPGQQLTLSIDHQTDFGYFLTDGEDTI LLHNSEMTEDIEDRDEVEVFIYVDQQERLAATMKIPIISADEYGWVEVVDKVEDMGVF VDVGLSKDALVATEHLPPYEDVWPQKGDKLYCMLKVTNRGRMFAKPAPEDIISELFTD ASEDLMNKELTGTVYRLIASGSFVITDDGIRCFIHPSERKEEPRLGSRVTGRVIQVKE DGSVNLSLLPRKQDAMSVDAECILTYMRMRNGAMPYSDKSQPDDIRERFNMSKAAFKR ALGHLMKNGKVYQENGWTYEKK*" /label="yitL CDS" gene 1131076..1131972 /gene="yitL" /locus_tag="BSU_11030" /old_locus_tag="BSU11030" /label="yitL gene" downshifts 1131959 /Source="Nicolas_upshifts" /id="D599" /incds=0 /nref=232 /ntot=261 /MaxReadThrough="1.78082" /MaxDrop="6.73614" /score="40.361011" /energy="-21.5" /TU="NA" /idTUdmin="U886" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1132025..1132609) /gene="yitM" /locus_tag="BSU_11040" /old_locus_tag="BSU11040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11557812" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388985.1" /db_xref="EnsemblGenomes-Gn:BSU11040" /db_xref="EnsemblGenomes-Tr:CAB12944" /db_xref="GOA:O06748" /db_xref="InterPro:IPR023888" /db_xref="SubtiList:BG13118" /db_xref="UniProtKB/Swiss-Prot:O06748" /translation="MKKAFLVFLSVVLVTTVFLVKQQESVAQAKQLEYSGEEIFKGFV FAQGEVGKQLPEVFNKAMTDKLNTKQAKAFANQVVADIKKEDADFFDNLKKAVYSKDA LKVDELLKKAGQIVEEKVEAAKEIAASKDDTSRVQAELVNTVDTANYFYYVSYVAAAG ALILIILAIDITPIAISDNVDREMAIRTLVDELN*" /label="yitM CDS" gene complement(1132025..1132609) /gene="yitM" /locus_tag="BSU_11040" /old_locus_tag="BSU11040" /label="yitM gene" downshifts complement(1132035) /Source="Nicolas_upshifts" /id="D600" /incds=0 /nref=68 /ntot=158 /MaxReadThrough="1.3386" /MaxDrop="7.40935" /score="10.143892" /energy="-21.5" /TU="NA" /idTUdmin="U888" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1132606..1133535) /gene="yitO" /locus_tag="BSU_11055" /old_locus_tag="BSU11055" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11557812, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein with HTTM domain" /protein_id="NP_388987.2" /db_xref="EnsemblGenomes-Gn:BSU11055" /db_xref="EnsemblGenomes-Tr:CAB12946" /db_xref="GOA:O06750" /db_xref="InterPro:IPR011020" /db_xref="InterPro:IPR023894" /db_xref="SubtiList:BG13120" /db_xref="UniProtKB/Swiss-Prot:O06750" /translation="MLENIKQTITRWDERNPWTNVYGLARSIIALSSLLTLLINHPSL IMKPASGISSYPACKMNLSLFCLGENNYMMLNLFRWVCIAILVLVVIGWRPRITGVLH WYVSYSLQSSLIVIDGGEQAAAVMTFLLLPITLTDPRKWHWSTRPIEGKRTLGKITAF ISYFVIRIQVAVLYFHSTVAKLSQQEWVDGTAVYYFAQEKTIGFNGFFQALTKPIVTS PFVVIPTWGTLLVQIVIFAALFAPKKHWRLILIIAVFMHEIFAVMLGLISFSIIMAGI LILYLTPIDSTIQFTYIRRLLWNKKHKKGEVSV*" /label="yitO CDS" gene complement(1132606..1133535) /gene="yitO" /locus_tag="BSU_11055" /old_locus_tag="BSU11055" /label="yitO gene" upshifts complement(1132693) /Source="Nicolas_upshifts" /id="U888" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.232767232767233" /psig="0.63936063936064" /xcortree=2974 /SigmaFactorBS="agtcatgctgggcctcatcagtttttcgattatcatggccgg cattttgatattgtatctcaCtcctatcgattccacgattcaatttacatatattcgc a" /listShort="yitM" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1133520..1134056) /gene="yitP" /locus_tag="BSU_11070" /old_locus_tag="BSU11070" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 6289325, 11557812" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_388988.1" /db_xref="EnsemblGenomes-Gn:BSU11070" /db_xref="EnsemblGenomes-Tr:CAB12947" /db_xref="GOA:O06751" /db_xref="InterPro:IPR023902" /db_xref="SubtiList:BG13121" /db_xref="UniProtKB/Swiss-Prot:O06751" /translation="MQKSISFFVIFSILWGSLFLFSIIGSLGTTPIPLTKDSKFLMSS ILPQGWGFFSKNPRDTAIGLYEAENASAKVRWPNMRADNLFGLYRYGRSQGVEMGVIY SQVGKEQWTACKEKDLGACKSKAKTVQLKTPAPRPLLCGSYYLTKEDIVPWSYSKYTP SSYQVKSIVKVVISCSKT*" /label="yitP CDS" gene complement(1133520..1134056) /gene="yitP" /locus_tag="BSU_11070" /old_locus_tag="BSU11070" /label="yitP gene" promotor_-10 complement(1134092..1134111) /Source="Nicolas_upshift_promotors" /id="U889" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.71028971028971" /psig="0.988011988011988" /xcortree=2975 /SigmaFactorBS="ccttttaacaaaaatggaatttctcatactttttaacCTTTt tattacataaatgTTTTTATATTATGAAAAGTGtaaaaacgattcttcaggttaaaag g" /listShort="yitP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1134106) /Source="Nicolas_upshifts" /id="U889" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.71028971028971" /psig="0.988011988011988" /xcortree=2975 /SigmaFactorBS="ccttttaacaaaaatggaatttctcatactttttaacCTTTt tattacataaatgTTTTTATATTATGAAAAGTGtaaaaacgattcttcaggttaaaag g" /listShort="yitP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1134126..1134129) /Source="Nicolas_upshift_promotors" /id="U889" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.71028971028971" /psig="0.988011988011988" /xcortree=2975 /SigmaFactorBS="ccttttaacaaaaatggaatttctcatactttttaacCTTTt tattacataaatgTTTTTATATTATGAAAAGTGtaaaaacgattcttcaggttaaaag g" /listShort="yitP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1134197..1134204 /Source="Nicolas_upshift_promotors" /id="U890" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.767232767232767" /psig=1 /xcortree=3150 /SigmaFactorBS="aaaggaaaaacaggacattttacactgctatatgtGATTGAT AtatagtgtttttttCGATATATTTAAACCATGAAaacgaatcaagttaatgaccgct g" /listShort="yizB, yitQ, yitR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1134219..1134238 /Source="Nicolas_upshift_promotors" /id="U890" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.767232767232767" /psig=1 /xcortree=3150 /SigmaFactorBS="aaaggaaaaacaggacattttacactgctatatgtGATTGAT AtatagtgtttttttCGATATATTTAAACCATGAAaacgaatcaagttaatgaccgct g" /listShort="yizB, yitQ, yitR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1134222 /Source="Nicolas_upshifts" /id="U890" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.767232767232767" /psig=1 /xcortree=3150 /SigmaFactorBS="aaaggaaaaacaggacattttacactgctatatgtGATTGAT AtatagtgtttttttCGATATATTTAAACCATGAAaacgaatcaagttaatgaccgct g" /listShort="yizB, yitQ, yitR" /GFF_Attribute="listLong" /label="upshifts" CDS 1134234..1134581 /gene="yizB" /locus_tag="BSU_11079" /old_locus_tag="BSU11079" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23504016; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="YP_003097701.1" /db_xref="EnsemblGenomes-Gn:BSU11079" /db_xref="EnsemblGenomes-Tr:CAX52589" /db_xref="GOA:C0H3Y4" /db_xref="InterPro:IPR005149" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="UniProtKB/Swiss-Prot:C0H3Y4" /translation="MKTNQVNDRWIVQFRKGIFELAILSLLRSKPMYGYELTSSLKTT SALAISEGAIYPILKRMTEKGWIEFFWEDSLDGPKRKYYKMTQKGEEMLKERLEKYLE THQALLSLSGDLL*" /label="yizB CDS" gene 1134234..1134581 /gene="yizB" /locus_tag="BSU_11079" /old_locus_tag="BSU11079" /label="yizB gene" CDS 1134578..1135165 /gene="yitQ" /locus_tag="BSU_11080" /old_locus_tag="BSU11080" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 23504016" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388989.2" /db_xref="EnsemblGenomes-Gn:BSU11080" /db_xref="EnsemblGenomes-Tr:CAB12948" /db_xref="GOA:O06752" /db_xref="SubtiList:BG13122" /db_xref="UniProtKB/Swiss-Prot:O06752" /translation="MNGQLIIDRYMEELNAELANMPDVERENAIDELKGHITAFVQDR IKAGLSEEELQEAVESEFSHPKELAELMMGDGGETKRRRSLLGKSWISVLLIVTIIAL PLLPSDFRHLPLAVYLMVLAGYVWKRKKLVMFAGVRKNKMRSQKEIVKISRVGAVYLL FLAVVLLLSPFLNALVVLLLIAVSCAAFFLFLNIK*" /label="yitQ CDS" gene 1134578..1135165 /gene="yitQ" /locus_tag="BSU_11080" /old_locus_tag="BSU11080" /label="yitQ gene" CDS 1135185..1135478 /gene="yitR" /locus_tag="BSU_11090" /old_locus_tag="BSU11090" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_388990.1" /db_xref="EnsemblGenomes-Gn:BSU11090" /db_xref="EnsemblGenomes-Tr:CAB12949" /db_xref="GOA:O06753" /db_xref="InterPro:IPR017259" /db_xref="SubtiList:BG13123" /db_xref="UniProtKB/Swiss-Prot:O06753" /translation="MEISINYLLIVIALLFFVVAYFVGIKKQTWMLAGFNEARIRDKD RLARIAGYFFLNSGLFILLNSFISFQGQEQLIPPLILAYGAGVIIYVNKKLVE*" /label="yitR CDS" gene 1135185..1135478 /gene="yitR" /locus_tag="BSU_11090" /old_locus_tag="BSU11090" /label="yitR gene" downshifts 1135458 /Source="Nicolas_upshifts" /id="D601" /incds=0 /nref=119 /ntot=240 /MaxReadThrough="1.96008" /MaxDrop="5.72545" /score="2.11183863" /energy="-12.6" /TU="NA" /idTUdmin="U890" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 1135502 /Source="Nicolas_upshifts" /id="D602" /incds=0 /nref=1 /ntot=15 /MaxReadThrough="0.34732" /MaxDrop="3.0285" /score="2.11183863" /energy="-12.6" /TU="NA" /idTUdmin="U890" /TUdmin=44 /isTUend="FALSE" /label="downshifts" CDS 1135614..1137230 /gene="nprB" /locus_tag="BSU_11100" /old_locus_tag="BSU11100" /EC_number="3.4.24.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:1917867, 16672610" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1917867, 16672610; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="extracellular neutral protease B" /protein_id="NP_388991.1" /db_xref="EnsemblGenomes-Gn:BSU11100" /db_xref="EnsemblGenomes-Tr:CAB12950" /db_xref="GOA:P39899" /db_xref="InterPro:IPR001570" /db_xref="InterPro:IPR011096" /db_xref="InterPro:IPR013856" /db_xref="InterPro:IPR023612" /db_xref="InterPro:IPR025711" /db_xref="SubtiList:BG10691" /db_xref="UniProtKB/Swiss-Prot:P39899" /translation="MRNLTKTSLLLAGLCTAAQMVFVTHASAEESIEYDHTYQTPSYI IEKSPQKPVQNTTQKESLFSYLDKHQTQFKLKGNANSHFRVSKTIKDPKTKQTFFKLT EVYKGIPIYGFEQAVAMKENKQVKSFFGKVHPQIKDVSVTPSISEKKAIHTARRELEA SIGKIEYLDGEPKGELYIYPHDGEYDLAYLVRLSTSEPEPGYWHYFIDAKNGKVIESF NAIHEAAGTGIGVSGDEKSFDVTEQNGRFYLADETRGKGINTFDAKNLNETLFTLLSQ LIGYTGKEIVSGTSVFNEPAAVDAHANAQAVYDYYSKTFGRDSFDQNGARITSTVHVG KQWNNAAWNGVQMVYGDGDGSKFKPLSGSLDIVAHEITHAVTQYSAGLLYQGEPGALN ESISDIMGAMADRDDWEIGEDVYTPGIAGDSLRSLEDPSKQGNPDHYSNRYTGTEDYG GVHINSSIHNKAAYLLAEGGVHHGVQVEGIGREASEQIYYRALTYYVTASTDFSMMKQ AAIEAANDLYGEGSKQSASVEKAYEAVGIL*" /label="nprB CDS" gene 1135614..1137230 /gene="nprB" /locus_tag="BSU_11100" /old_locus_tag="BSU11100" /label="nprB gene" downshifts 1137218 /Source="Nicolas_upshifts" /id="D603" /incds=0 /nref=2 /ntot=55 /MaxReadThrough="0.278770000000001" /MaxDrop="3.08544" /score="2.81939887" /energy="-8.6" /TU="NA" /idTUdmin="U890" /TUdmin=1760 /isTUend="FALSE" /label="downshifts" CDS complement(1137277..1138128) /gene="fakBB" /locus_tag="BSU_11110" /old_locus_tag="BSU11110" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 25002480, 26774272, 27435445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fatty acid kinase fatty acid binding subunit B" /protein_id="NP_388992.1" /db_xref="EnsemblGenomes-Gn:BSU11110" /db_xref="EnsemblGenomes-Tr:CAB12951" /db_xref="GOA:P70945" /db_xref="InterPro:IPR003797" /db_xref="SubtiList:BG12244" /db_xref="UniProtKB/Swiss-Prot:P70945" /translation="MTVHLIADSATDLPRSYFEEKGIGFIPLRVSLGDKEFEDAVTIH ADQIFEAMQNGETPKTSQASPQTIKNVFLQYAETGDPALYIAFSSGLSGTYQTAVMIA NEVKEEFPDFDLRVIDSKCASLGYGLAVRHAADLCINGNTIQEIETSVKNFCSQLEHI FTVDDLTYLARGGRISKTSAFVGGLLNIKPLLQMEDGKLVPLEKIRGQKKLFKRIIEL MKERGDDWSNQTVGISYAANKEKATDMKHLIEEAFKPKEIIMHPISSAIGSHAGPGTL AIFFLRK*" /label="fakBB CDS" gene complement(1137277..1138128) /gene="fakBB" /locus_tag="BSU_11110" /old_locus_tag="BSU11110" /label="fakBB gene" downshifts complement(1137294) /Source="Nicolas_upshifts" /id="D604" /incds=0 /nref=209 /ntot=263 /MaxReadThrough="0.727580000000001" /MaxDrop="6.86927" /score="-1.24586831" /energy="-7.7" /TU="NA" /idTUdmin="U892" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1137675..1137682 /Source="Nicolas_upshift_promotors" /id="U891" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.78021978021978" /psig="0.996003996003996" /xcortree=2481 /SigmaFactorBS="gtaaaaatgtgttcaagctggctgcaaaagtTCTTTACAgac gtttcaatttcTTGTATTGTATTCCCGTTGAtacagagatcggcagcatgccggacag c" /listShort="S395, yitT, S396, ipi" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1137697..1137716 /Source="Nicolas_upshift_promotors" /id="U891" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.78021978021978" /psig="0.996003996003996" /xcortree=2481 /SigmaFactorBS="gtaaaaatgtgttcaagctggctgcaaaagtTCTTTACAgac gtttcaatttcTTGTATTGTATTCCCGTTGAtacagagatcggcagcatgccggacag c" /listShort="S395, yitT, S396, ipi" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1137702..1138227 /Source="Nicolas_S_feature" /locus_tag="new_1188125_1188650" /HighExp="G180, Paraq, G135, G150, Oxctl, C30, H2O2, LBGstat, LBGexp, Lbexp" /AntisenseName="yitS" /AntisenseCor="-0.45830528686941202" /AntisenseRegPval="-14.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S395" upshifts 1137704 /Source="Nicolas_upshifts" /id="U891" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.78021978021978" /psig="0.996003996003996" /xcortree=2481 /SigmaFactorBS="gtaaaaatgtgttcaagctggctgcaaaagtTCTTTACAgac gtttcaatttcTTGTATTGTATTCCCGTTGAtacagagatcggcagcatgccggacag c" /listShort="S395, yitT, S396, ipi" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1138169..1138188) /Source="Nicolas_upshift_promotors" /id="U892" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.558441558441558" /psig="0.841158841158841" /xcortree=594 /SigmaFactorBS="gctctttcttctttattatgttttcccttaaaacaaatattt gaAcacgattttggcaaattaaTATGATATAGTTGGCTTAACtctcatgataacgagc g" /listShort="yitS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1138192) /Source="Nicolas_upshifts" /id="U892" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.558441558441558" /psig="0.841158841158841" /xcortree=594 /SigmaFactorBS="gctctttcttctttattatgttttcccttaaaacaaatattt gaAcacgattttggcaaattaaTATGATATAGTTGGCTTAACtctcatgataacgagc g" /listShort="yitS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1138206..1138211 /Source="Nicolas_upshift_promotors" /id="U893" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=738 /SigmaFactorBS="gttaagccaactatatcatattaatttgccaaaatcgTGTTC AaatatttgttttaaGGGAAAACATAATAAAGAAgaaagagcggaggaacatgccatg g" /listShort="yitT, S396, ipi" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1138226..1138244 /Source="Nicolas_upshift_promotors" /id="U893" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=738 /SigmaFactorBS="gttaagccaactatatcatattaatttgccaaaatcgTGTTC AaatatttgttttaaGGGAAAACATAATAAAGAAgaaagagcggaggaacatgccatg g" /listShort="yitT, S396, ipi" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1138229 /Source="Nicolas_upshifts" /id="U893" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=738 /SigmaFactorBS="gttaagccaactatatcatattaatttgccaaaatcgTGTTC AaatatttgttttaaGGGAAAACATAATAAAGAAgaaagagcggaggaacatgccatg g" /listShort="yitT, S396, ipi" /GFF_Attribute="listLong" /label="upshifts" CDS 1138266..1139108 /gene="yitT" /locus_tag="BSU_11120" /old_locus_tag="BSU11120" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 23419162, 23824080; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_388993.1" /db_xref="EnsemblGenomes-Gn:BSU11120" /db_xref="EnsemblGenomes-Tr:CAB12952" /db_xref="GOA:P39803" /db_xref="InterPro:IPR003740" /db_xref="InterPro:IPR019264" /db_xref="SubtiList:BG10850" /db_xref="UniProtKB/Swiss-Prot:P39803" /translation="MVLDQTKKLLIVIIGALLNAAGLNLFLIPADVYASGFTGVAQLL SSVVDQYAPFYISTGTLLFLLNIPVGILGWLKVGKSFTVYSILSVALTTLFMGILPET SLSHDILLNAVFGGVISAVGIGLTLKYGASTGGLDIVAMVLAKWKDKPVGTYFFILNG IIILTAGLLQGWEKALYTLVTLYVTTRVIDAIHTRHMKLTAMIVTKKADEIKEAIYGK MVRGITTVPAKGAFTNEQKEMMIIVITRYELYDLEKIVKEVDPKAFTNIVQTTGIFGF FRKD*" /label="yitT CDS" gene 1138266..1139108 /gene="yitT" /locus_tag="BSU_11120" /old_locus_tag="BSU11120" /label="yitT gene" promotor_-35 1138761..1138769 /Source="Nicolas_upshift_promotors" /id="U894" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.968031968031968" /psig="0.968031968031968" /xcortree=467 /SigmaFactorBS="gcacgtatttcttcattctgaacgggattatcatcttgacgG CAGGATTAttgcaaggttGGGAGAAAGCATTATATACcctggttacactatatgtgac a" /listShort="S396, ipi" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1138780..1138798 /Source="Nicolas_upshift_promotors" /id="U894" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.968031968031968" /psig="0.968031968031968" /xcortree=467 /SigmaFactorBS="gcacgtatttcttcattctgaacgggattatcatcttgacgG CAGGATTAttgcaaggttGGGAGAAAGCATTATATACcctggttacactatatgtgac a" /listShort="S396, ipi" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1138780 /Source="Nicolas_upshifts" /id="U894" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.968031968031968" /psig="0.968031968031968" /xcortree=467 /SigmaFactorBS="gcacgtatttcttcattctgaacgggattatcatcttgacgG CAGGATTAttgcaaggttGGGAGAAAGCATTATATACcctggttacactatatgtgac a" /listShort="S396, ipi" /GFF_Attribute="listLong" /label="upshifts" S_feature 1139109..1139222 /Source="Nicolas_S_feature" /locus_tag="new_1189532_1189645" /HighExp="Etha, S8, Sw, M9-stat, S7, BC, Gly, S6, Salt, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH, SigB, SigA" /TUshortPSig="0.968, 0.998, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S396" CDS 1139223..1139582 /gene="ipi" /locus_tag="BSU_11130" /old_locus_tag="BSU11130" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8226659, 24555072" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8226659, 24555072; Product type f: factor" /codon_start=1 /transl_table=11 /product="intracellular proteinase inhibitor BsuPI" /protein_id="NP_388994.1" /db_xref="EnsemblGenomes-Gn:BSU11130" /db_xref="EnsemblGenomes-Tr:CAB12953" /db_xref="GOA:P39804" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR020481" /db_xref="PDB:3ISY" /db_xref="SubtiList:BG10852" /db_xref="UniProtKB/Swiss-Prot:P39804" /translation="MENQEVVLSIDAIQEPEQIKFNMSLKNQSERAIEFQFSTGQKFE LVVYDSEHKERYRYSKEKMFTQAFQNLTLESGETYDFSDVWKEVPEPGTYEVKVTFKG RAENLKQVQAVQQFEVK*" /label="ipi CDS" gene 1139223..1139582 /gene="ipi" /locus_tag="BSU_11130" /old_locus_tag="BSU11130" /label="ipi gene" downshifts 1139571 /Source="Nicolas_upshifts" /id="D605" /incds=0 /nref=34 /ntot=224 /MaxReadThrough="1.36729" /MaxDrop="5.6855" /score="43.7575824" /energy="-15.6" /TU="NA" /idTUdmin="U893" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1139613..1139810) /gene="yizC" /locus_tag="BSU_11139" /old_locus_tag="BSU11139" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; genus orphan" /protein_id="YP_003097702.1" /db_xref="EnsemblGenomes-Gn:BSU11139" /db_xref="EnsemblGenomes-Tr:CAX52590" /db_xref="InterPro:IPR024217" /db_xref="UniProtKB/Swiss-Prot:C0H3Y5" /translation="MRNELFQQAKSFVQQAVMVTNGFEEGDQEQAILRAKNAVSSAYA NSTDAERQQLHQFQNQLDKLQ*" /label="yizC CDS" gene complement(1139613..1139810) /gene="yizC" /locus_tag="BSU_11139" /old_locus_tag="BSU11139" /label="yizC gene" downshifts complement(1139626) /Source="Nicolas_upshifts" /id="D606" /incds=0 /nref=150 /ntot=257 /MaxReadThrough="1.42333" /MaxDrop="8.284" /score="2.35557074" /energy="-17.3" /TU="NA" /idTUdmin="U895" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1139811..1140007) /Source="Nicolas_S_feature" /locus_tag="new_1190234_1190430_c" /HighExp="S8, S6, S5, S7, nit, ferm, BT, G/S, Pyr, S4" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99834599999999996" /TUshortSig="SigGF, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S397" upshifts complement(1140007) /Source="Nicolas_upshifts" /id="U895" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=848 /SigmaFactorBS="aagaaggtccgtattaatttttcccaCTCATAAaccttactt tacccCACCATACTATTgaagacgactcatctcgtcaaagtatggaagggggcagtct c" /listShort="S397, yizC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1140009..1140020) /Source="Nicolas_upshift_promotors" /id="U895" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=848 /SigmaFactorBS="aagaaggtccgtattaatttttcccaCTCATAAaccttactt tacccCACCATACTATTgaagacgactcatctcgtcaaagtatggaagggggcagtct c" /listShort="S397, yizC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1140035..1140041) /Source="Nicolas_upshift_promotors" /id="U895" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=848 /SigmaFactorBS="aagaaggtccgtattaatttttcccaCTCATAAaccttactt tacccCACCATACTATTgaagacgactcatctcgtcaaagtatggaagggggcagtct c" /listShort="S397, yizC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1140067..1140879) /gene="ribZC" /locus_tag="BSU_11140" /old_locus_tag="BSU11140" /function="4.9: Riboflavin, FMN, and FAD" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 25012491, 26316208; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5-amino-6-ribitylamino-2,4(1H, 3H)-pyrimidinedione 5'-phosphate phosphatase (promiscuous)" /protein_id="NP_388995.1" /db_xref="EnsemblGenomes-Gn:BSU11140" /db_xref="EnsemblGenomes-Tr:CAB12954" /db_xref="GOA:P70947" /db_xref="InterPro:IPR000150" /db_xref="InterPro:IPR006379" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG12245" /db_xref="UniProtKB/Swiss-Prot:P70947" /translation="METKPYLIALDLDGTLLKDDKTISENTLHTIQRLKDDGHYVCIS TGRPYRSSSMYYQQMELTTPIVNFNGAFVHHPQDDSWGRYHTSLPLDVVKQLVDISES YNVHNVLAEVIDDVYFHYHDEHLIDAFNMNTTNVTVGDLRENLGEDVTSVLIHAKEED VPAIRSYLSDVHAEVIDHRRWAAPWHVIEIIKSGMNKAVGLQKISDYYGVPRERIIAF GDEDNDLEMLEFAGCGVAMGNGIDAVKQIANRTTATNEEDGVARFLKEYFSL*" /label="ribZC CDS" gene complement(1140067..1140879) /gene="ribZC" /locus_tag="BSU_11140" /old_locus_tag="BSU11140" /label="ribZC gene" promotor_-10 complement(1140917..1140936) /Source="Nicolas_upshift_promotors" /id="U896" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.483516483516484" /psig=1 /xcortree=2075 /SigmaFactorBS="tgtgcccctccttaggataaccataatcataagtgtaacaTG TAGACAataaagatggtaaAAAGCTACACTGTAAGTAAGgcaaaacaagcaaaatcta a" /listShort="yitU, S397, yizC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 1140937..1140944 /Source="Nicolas_upshift_promotors" /id="U897" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1854 /SigmaFactorBS="tagattttgcttgttttgccttacttacagtgtagctttTTA CCATCtttattgtctaCATGTTACACTTATGATTATggttatcctaaggaggggcaca t" /listShort="yitV, yitW, S398, yitY, yitZ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(1140937) /Source="Nicolas_upshifts" /id="U896" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.483516483516484" /psig=1 /xcortree=2075 /SigmaFactorBS="tgtgcccctccttaggataaccataatcataagtgtaacaTG TAGACAataaagatggtaaAAAGCTACACTGTAAGTAAGgcaaaacaagcaaaatcta a" /listShort="yitU, S397, yizC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1140950..1140957) /Source="Nicolas_upshift_promotors" /id="U896" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.483516483516484" /psig=1 /xcortree=2075 /SigmaFactorBS="tgtgcccctccttaggataaccataatcataagtgtaacaTG TAGACAataaagatggtaaAAAGCTACACTGTAAGTAAGgcaaaacaagcaaaatcta a" /listShort="yitU, S397, yizC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1140956..1140975 /Source="Nicolas_upshift_promotors" /id="U897" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1854 /SigmaFactorBS="tagattttgcttgttttgccttacttacagtgtagctttTTA CCATCtttattgtctaCATGTTACACTTATGATTATggttatcctaaggaggggcaca t" /listShort="yitV, yitW, S398, yitY, yitZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1140958 /Source="Nicolas_upshifts" /id="U897" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1854 /SigmaFactorBS="tagattttgcttgttttgccttacttacagtgtagctttTTA CCATCtttattgtctaCATGTTACACTTATGATTATggttatcctaaggaggggcaca t" /listShort="yitV, yitW, S398, yitY, yitZ" /GFF_Attribute="listLong" /label="upshifts" CDS 1141000..1141767 /gene="yitV" /locus_tag="BSU_11150" /old_locus_tag="BSU11150" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 28293230; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative carboxylesterase" /protein_id="NP_388996.1" /db_xref="EnsemblGenomes-Gn:BSU11150" /db_xref="EnsemblGenomes-Tr:CAB12955" /db_xref="GOA:P70948" /db_xref="InterPro:IPR001375" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12246" /db_xref="UniProtKB/Swiss-Prot:P70948" /translation="MIQIENQTVSGIPFLHIVKEENRHRAVPLVIFIHGFTSAKEHNL HIAYLLAEKGFRAVLPEALHHGERGEEMAVEELAGHFWDIVLNEIEEIGVLKNHFEKE GLIDGGRIGLAGTSMGGITTLGALTAYDWIKAGVSLMGSPNYVELFQQQIDHIQSQGI EIDVPEEKVQQLMKRLELRDLSLQPEKLQQRPLLFWHGAKDKVVPYAPTRKFYDTIKS HYSEQPERLQFIGDENADHKVPRAAVLKTIEWFETYL*" /label="yitV CDS" gene 1141000..1141767 /gene="yitV" /locus_tag="BSU_11150" /old_locus_tag="BSU11150" /label="yitV gene" promotor_-35 1141776..1141782 /Source="Nicolas_upshift_promotors" /id="U898" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.723276723276723" /psig=1 /xcortree=2071 /SigmaFactorBS="aaacgattgaatggtttgaaacgtacttataaagcactaaGT TATTAacaagagctgaattTACGTTATACTGTAGAAAAAaggagtgagggaacgtgga a" /listShort="yitW, S398, yitY, yitZ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1141796 /Source="Nicolas_upshifts" /id="U898" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.723276723276723" /psig=1 /xcortree=2071 /SigmaFactorBS="aaacgattgaatggtttgaaacgtacttataaagcactaaGT TATTAacaagagctgaattTACGTTATACTGTAGAAAAAaggagtgagggaacgtgga a" /listShort="yitW, S398, yitY, yitZ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1141797..1141816 /Source="Nicolas_upshift_promotors" /id="U898" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.723276723276723" /psig=1 /xcortree=2071 /SigmaFactorBS="aaacgattgaatggtttgaaacgtacttataaagcactaaGT TATTAacaagagctgaattTACGTTATACTGTAGAAAAAaggagtgagggaacgtgga a" /listShort="yitW, S398, yitY, yitZ" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1141831..1142139 /gene="yitW" /locus_tag="BSU_11160" /old_locus_tag="BSU11160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9209063; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative protein involved in Fe-S cluster assembly, PaaD-like" /protein_id="NP_388997.1" /db_xref="EnsemblGenomes-Gn:BSU11160" /db_xref="EnsemblGenomes-Tr:CAB12956" /db_xref="InterPro:IPR002744" /db_xref="InterPro:IPR034904" /db_xref="SubtiList:BG12247" /db_xref="UniProtKB/Swiss-Prot:P70949" /translation="MEEALKENIMGALEQVVDPELGVDIVNLGLVYDVDMDEDGLTHI TMTLTSMGCPLAPIIVDEVKKALADLPEVKDTEVHIVWNPPWTRDKMSRYAKIALGIQ *" /label="yitW CDS" gene 1141831..1142139 /gene="yitW" /locus_tag="BSU_11160" /old_locus_tag="BSU11160" /label="yitW gene" downshifts 1142124 /Source="Nicolas_upshifts" /id="D607" /incds=0 /nref=3 /ntot=55 /MaxReadThrough="5.65659" /MaxDrop="4.5598" /score="14.9971829" /energy="-14.7" /TU="U897,U898" /idTUdmin="U897" /TUdmin="-2244" /isTUend="FALSE" /label="downshifts" S_feature 1142169..1142434 /Source="Nicolas_S_feature" /locus_tag="new_1192592_1192857" /HighExp="Etha, dia15, dia5, H2O2, LoTm, Salt, S6, Diami, S8, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba=1 /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S398" CDS 1142435..1143865 /gene="yitY" /locus_tag="BSU_11170" /old_locus_tag="BSU11170" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12682299, 16956367; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative FMN/FAD-binding oxidoreductase" /protein_id="NP_388999.3" /db_xref="EnsemblGenomes-Gn:BSU11170" /db_xref="EnsemblGenomes-Tr:CAB12958" /db_xref="GOA:Q796P5" /db_xref="InterPro:IPR006094" /db_xref="InterPro:IPR016164" /db_xref="InterPro:IPR016166" /db_xref="InterPro:IPR016167" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR036318" /db_xref="SubtiList:BG12249" /db_xref="UniProtKB/Swiss-Prot:Q796P5" /translation="MKKKLLAFALCTGAYAALFAYSVNSEQKTATSEMTDVSRLMPVK IKQTVKGQEEEMLIDTVKEANRKNIKISIAGAQHSMGGHTYYEDGIVLDMTGYNKILS LDQEKKTIRVQSGATWNDIQKYVNPYGLAVKVMQSQNIFTIGGSLSANAHGRDIRYGS LIDTVKSFRLLKADGMIITVTPKDDLFTAVIGGYGLFGVILDVTLELTDDELYVMKTE KMNYSTYSDYFSKHVKGNPDVRMHLARISTAKKGFLKDMYVTNYVLANHQDQLSSYSE LKEDEYTGATKFALGLSRRYEWGRNWLWDTQQSYFLSQNGTEISRNNVMRSESKFLEY ENNDNTDVLQEYFVPVKEYGSYIDDLRQTLSDEDLNLLNITIRYVQKNEKADLSYAKD DMFSLVLLINEGFSKEDQADTARIIRRMTDVAIKHGGSYYLPYMTYQTKAQMRQAYPK SEAFFQKKRTYDPDERFMNYFYQRYK*" /label="yitY CDS" gene 1142435..1143865 /gene="yitY" /locus_tag="BSU_11170" /old_locus_tag="BSU11170" /label="yitY gene" CDS 1143910..1144404 /gene="yitZ" /locus_tag="BSU_11180" /old_locus_tag="BSU11180" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative transport protein" /protein_id="NP_389000.1" /db_xref="EnsemblGenomes-Gn:BSU11180" /db_xref="EnsemblGenomes-Tr:CAB12959" /db_xref="GOA:P70952" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12250" /db_xref="UniProtKB/Swiss-Prot:P70952" /translation="MFFASSLIFPFYILFVKNIGSSYTQFGFSYGLFGLSGALIYPLL GRLSERFDSRYFLLLNSWGMAVLLLYVPHIGSVVQVYIVQVLLGLFGAMQKHGEKVLI ANFTDSGERGKKIGNYHFWTAVFSAAAIMLGGFLADFFTVQMIFYASSILYFLSGLMM MKTG*" /label="yitZ CDS" gene 1143910..1144404 /gene="yitZ" /locus_tag="BSU_11180" /old_locus_tag="BSU11180" /label="yitZ gene" downshifts 1144368 /Source="Nicolas_upshifts" /id="D608" /incds=0 /nref=49 /ntot=208 /MaxReadThrough="1.74762" /MaxDrop="4.22077" /score="34.1294744" /energy="-13.2" /TU="NA" /idTUdmin="U897" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1144542..1144549 /Source="Nicolas_upshift_promotors" /id="U899" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.861138861138861" /psig="0.999000999001" /xcortree=2913 /SigmaFactorBS="gcggaattcccattgaacagaaaatttataaatgaataaaaa tattaaatatacGATTGAATtaatttttattcaTGTTATAATGTTAAATAATTtcaca a" /listShort="argC, argJ, argB, argD, carA, carB, argF, yjzC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1144548 /Source="Nicolas_upshifts" /id="U899" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.861138861138861" /psig="0.999000999001" /xcortree=2913 /SigmaFactorBS="gcggaattcccattgaacagaaaatttataaatgaataaaaa tattaaatatacGATTGAATtaatttttattcaTGTTATAATGTTAAATAATTtcaca a" /listShort="argC, argJ, argB, argD, carA, carB, argF, yjzC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1144563..1144582 /Source="Nicolas_upshift_promotors" /id="U899" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.861138861138861" /psig="0.999000999001" /xcortree=2913 /SigmaFactorBS="gcggaattcccattgaacagaaaatttataaatgaataaaaa tattaaatatacGATTGAATtaatttttattcaTGTTATAATGTTAAATAATTtcaca a" /listShort="argC, argJ, argB, argD, carA, carB, argF, yjzC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1144611..1145648 /gene="argC" /locus_tag="BSU_11190" /old_locus_tag="BSU11190" /EC_number="1.2.1.38" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2117746, 3005232, 3106155, 6096674, 6096675, 8025667, 18455186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2117746, 3005232, 3106155, 6096674, 6096675, 8025667, 18455186; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylglutamate gamma-semialdehyde dehydrogenase" /protein_id="NP_389001.2" /db_xref="EnsemblGenomes-Gn:BSU11190" /db_xref="EnsemblGenomes-Tr:CAB12960" /db_xref="GOA:P23715" /db_xref="InterPro:IPR000534" /db_xref="InterPro:IPR000706" /db_xref="InterPro:IPR012280" /db_xref="InterPro:IPR023013" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10191" /db_xref="UniProtKB/Swiss-Prot:P23715" /translation="MKIGIVGATGYGGTELVRILSHHPHAEECILYSSSGEGNVYSEG YPHLTGLADQQLKPIDMNTIKHEIDIMFLAAPPGVSSELTPKLADAGITVIDLSGDLR IKEPAEYEKWYKRTAAPKAVIQEAVYGLAELNQLQIQQAKLIANPGCFPTAVLLGLAP LAQKKLLDESFVIVDAKTGVSGAGRKASMGTHFSELNDNFKIYKVNEHQHTPEIEQAL NEWQPGLGPITFSAHLVPMTRGIMATMYTRLTCDLTADDLHDLYSEFYQDSYFVRVRP KGQYPQTKEVYGSNFCDIAVTLDERTNRVTIVSVIDNLMKGAAGQAVQNFNLMNGWNE ETGLTITPIYP*" /label="argC CDS" gene 1144611..1145648 /gene="argC" /locus_tag="BSU_11190" /old_locus_tag="BSU11190" /label="argC gene" CDS 1145668..1146888 /gene="argJ" /locus_tag="BSU_11200" /old_locus_tag="BSU11200" /EC_number="2.3.1.1" /EC_number="2.3.1.35" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8025667, 10931207, 16409639, 24163341" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8025667, 10931207, 16409639, 24163341; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ornithine acetyltransferase; amino-acid acetyltransferase" /protein_id="NP_389002.2" /db_xref="EnsemblGenomes-Gn:BSU11200" /db_xref="EnsemblGenomes-Tr:CAB12961" /db_xref="GOA:P36843" /db_xref="InterPro:IPR002813" /db_xref="InterPro:IPR016117" /db_xref="SubtiList:BG10192" /db_xref="UniProtKB/Swiss-Prot:P36843" /translation="MIQLSEDQIVKVTGDVSSPKGFQAKGVHCGLRYSKKDLGVIISE TPAVSAAVYTQSHFQAAPIKVTQDSLKHGPTLKAVIVNSAIANACTGEQGLKDAYTMR ESFASQLGIEPELVAVSSTGVIGEHLDMEKIHAGIELLKETPAGSGDFEEAILTTDTV IKQTCYELAIGGKTVTIGGAAKGSGMIHPNMATMLGFVTTDAAIEEKALQKALREITD VSFNQITVDGETSTNDMVLVMANGCAENECLTEDHPDWPVFKKALLLTCEDLAKEIAR DGEGATKLIEAQVQGAKNNLDANVIAKKIVGSNLVKTAVYGTDANWGRIIGAIGHSAA QVTAEEVEVYLGGQCLFKNNEPQPFSESIAKEYLEGDEITIVIKMAEGDGNGRAWGCD LTYDYIKINASYRT*" /label="argJ CDS" gene 1145668..1146888 /gene="argJ" /locus_tag="BSU_11200" /old_locus_tag="BSU11200" /label="argJ gene" CDS 1146903..1147679 /gene="argB" /locus_tag="BSU_11210" /old_locus_tag="BSU11210" /EC_number="2.7.2.8" /experiment="publication(s) with functional evidences, PMID:3005232, 8473852" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3005232, 8473852; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylglutamate 5-phosphotransferase (acetylglutamate kinase)" /protein_id="NP_389003.1" /db_xref="EnsemblGenomes-Gn:BSU11210" /db_xref="EnsemblGenomes-Tr:CAB12962" /db_xref="GOA:P68729" /db_xref="InterPro:IPR001048" /db_xref="InterPro:IPR001057" /db_xref="InterPro:IPR004662" /db_xref="InterPro:IPR036393" /db_xref="SubtiList:BG10193" /db_xref="UniProtKB/Swiss-Prot:P68729" /translation="MKKTIVFKCGGSVIRELSEEFYQNLKELRASGWKLAIVHGGGPE ITNMLKRLNIKTEFSGGQRKTTKPVLEVAEMVLSGSVNKFFVAELAKHGLRAAGISGK DGGLLEADYLDPETYGEVGEIKKVDASMVNALMENGIIPVIAPLSMTSDCKTLNVNAD LAASAVAGALEADKLMFVTDVDGIMKEKQRLDVLTPKEIQMLIKQEVITGGMIPKVNS ALSALSDQVSEVMIVNGKGSFFAEQTFQGTKIVKAKEAVS*" /label="argB CDS" gene 1146903..1147679 /gene="argB" /locus_tag="BSU_11210" /old_locus_tag="BSU11210" /label="argB gene" CDS 1147676..1148833 /gene="argD" /locus_tag="BSU_11220" /old_locus_tag="BSU11220" /EC_number="2.6.1.11" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17012789; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="N-acetylornithine aminotransferase" /protein_id="NP_389004.2" /db_xref="EnsemblGenomes-Gn:BSU11220" /db_xref="EnsemblGenomes-Tr:CAB12963" /db_xref="GOA:P36839" /db_xref="InterPro:IPR004636" /db_xref="InterPro:IPR005814" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG10194" /db_xref="UniProtKB/Swiss-Prot:P36839" /translation="MSSLFQTYGRWDIDIKKAKGTYVEDQNGKTYLDFIQGIAVSNLG HCHEAVTEAVKKQLDSVWHVSNLFQNSLQEQAAQKLAAHSAGDLVFFCNSGAEANEGA IKLARKATGKTKIITFLQSFHGRTYAGMAATGQDKIKTGFGPMLGGFHYLPYNDPSAF KALGEEGDIAAVMLETVQGEGGVNPASAEFLSAVQSFCKEKQALLIIDEIQTGIGRTG KGFAYEHFGLSPDIITVAKGLGNGFPVGAVIGKKQLGEAFTPGSHGTTFGGNMLAMAA VNATLQIVFQPDFLQEAADKGAFLKEQLEAELKSPFVKQIRGKGLMLGIECDGPVADI IAELQTLGLLVLPAGPNVIRLLPPLTVTKDEIAEAVSKLKQAIAHHSAVNQ*" /label="argD CDS" gene 1147676..1148833 /gene="argD" /locus_tag="BSU_11220" /old_locus_tag="BSU11220" /label="argD gene" CDS 1148904..1149959 /gene="carA" /locus_tag="Delta6_BSU_11230_SNPvariant" /old_locus_tag="BSU_11230" /EC_number="6.3.5.5" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:216664, 230177, 1116335" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 216664, 230177, 1116335; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="arginine-specific carbamoyl-phosphate synthetase(small subunit)" /protein_id="NP_389005.2" /db_xref="EnsemblGenomes-Gn:BSU11230" /db_xref="EnsemblGenomes-Tr:CAB12964" /db_xref="GOA:P36838" /db_xref="InterPro:IPR002474" /db_xref="InterPro:IPR006274" /db_xref="InterPro:IPR017926" /db_xref="InterPro:IPR029062" /db_xref="InterPro:IPR035686" /db_xref="InterPro:IPR036480" /db_xref="SubtiList:BG10195" /db_xref="UniProtKB/Swiss-Prot:P36838" /modified_by="User" /translation="MEGYLVLEDGTSFSGELDGHENCTGEAVFFTGMTGYQEVLTDPS YKGQIIVFTYPLIGNYGINEKDFESKKPQVKAAVVYEACDHFSHYEAVYSLKEYLQKW NIPLLTHVDTRAVVKKIRANGTMGATVTASKEGAEIALQPENVAEQASAQEISTFGDG NKHIALIDFGYKKSIASSLVKRGCKVTVVPYQQMEAVYNIKPDGLSNGPGDPKAIQPY LGKIKSIISRFPTLGICLGHQLIALAFGGNTFKLPFGHRGANHPVIDRKTKRVFMTSQ NHSYVVDEQSINEEELTIRFHHVNDTSVEGLAHKKLPVMSVQFHPEAHPGPAESEWIF DDYLKNVIPARREIAHA*" /label="Delta6_BSU_11230_SNPvariant" gene 1148904..1149959 /gene="carA" /locus_tag="Delta6_BSU_11230_SNPvariant" /old_locus_tag="BSU_11230" /modified_by="User" /label="Delta6_BSU_11230_SNPvariant" Polymorphism join(1149514,1149515) /Source="geneious" /ID="SNP_BsDelta6_1199938_1199943" /Polymorphism_Type="Deletion" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=6 /Amino_Acid_Change="GIV -> G" /CDS_Position=612 /Change="-AATTGT" /Codon_Change="GGA,ATT,GTG -> GGG" /Coverage="183 -> 185" /locus_tag="BSU_11230" /Protein_Effect="Deletion" /Reference_Frequency /Reference_Nucleotides="AATTGT" /Variant_Nucleotides /Variant_P_Value=0 /Variant_Raw_Frequency=174 /comment="Delta6_BSU_11230_SNPvariant" / /modified_by="User" /label="Polymorphism_Delta6" misc_feature complement(1149793..1149812) /Source="Nicolas_upshift_promotors" /id="U900" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.869130869130869" /psig="0.949050949050949" /xcortree=2066 /SigmaFactorBS="gtggaattgaacactcatgacaggcagttttttatgggcaag cccttcaacTGACGTATCATTGACATGATgaaacctgatggtgagctcttcttcatta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1149803) /Source="Nicolas_upshifts" /id="U900" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.869130869130869" /psig="0.949050949050949" /xcortree=2066 /SigmaFactorBS="gtggaattgaacactcatgacaggcagttttttatgggcaag cccttcaacTGACGTATCATTGACATGATgaaacctgatggtgagctcttcttcatta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 1149952..1153044 /gene="carB" /locus_tag="BSU_11240" /old_locus_tag="BSU11240" /EC_number="6.3.5.5" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:216664, 1116335" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 216664, 1116335; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="arginine-specific carbamoyl-phosphate synthetase(large subunit)" /protein_id="NP_389006.3" /db_xref="EnsemblGenomes-Gn:BSU11240" /db_xref="EnsemblGenomes-Tr:CAB12965" /db_xref="GOA:P18185" /db_xref="InterPro:IPR005479" /db_xref="InterPro:IPR005480" /db_xref="InterPro:IPR005483" /db_xref="InterPro:IPR006275" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="InterPro:IPR036897" /db_xref="SubtiList:BG10196" /db_xref="UniProtKB/Swiss-Prot:P18185" /translation="MPKDTSISSILVIGSGPIIIGQAAEFDYSGTQGCIALKEEGYRV ILVNSNPATIMTDEAFADEIYFEPLTAESLTAIIKKERPDGLLANLGGQTALNLAVEL EETGVLKEHGVKLLGTSVETIQKGEDREKFRSLMNELKQPVPESEIVDNEADALHFAE SIGFPVIIRPAYTLGGKGGGIAPDKEAFTAMIKQALLASPINQCLVEKSIAGFKEIEY EVMRDSNNTCITVCNMENIDPVGVHTGDSIVVAPSQTLTDEDYQMLRTASLTIISALD VVGGCNIQFALDPFSKQYYVIEVNPRVSRSSALASKATGYPIAKMAAKLAVGYTLDEL KNPLTGSTYASFEPALDYVIVKFPRWPFDKFKNADRKLGTKMKATGEVMAIERNLEAA IQKAAASLELKNIGTHLPELSGLSIDTLWDLAITPDDRRFFVVMELLSRSVSIDDIHE KTKIDPFFLHTFDNIIKLENRLMEAGSDLSFELLKKAKEKGFSDATIASLISKTEEEV RALRKEMGITPSFKIVDTCAAEFDAKTNYFYSTYFGETDGDISRKEKKRALIIGSGPI RIGQGVEFDYSAVHGVLTLQELGFETIMINNNPETVSTDYEIADRLYFEPMTTEHIVN VAEQENIDFAIVQFGGQTAINAAEALEKAGITLLGTSFQTLDVLEDRDQFYQLLDELG LKHAKGEIAYTKEEAASKASEIGYPVLIRPSYVIGGMGMIIVDSQAQLSQLLNDEDSM PYPILIDQYVSGKEVEIDLISDGEEVFIPTYTEHIERAGVHSGDSFAILPGPSITSGL QQGMKDAAQKIARKLSFKGIMNIQFVIDNGNILVLEVNPRASRTVPVVSKVMGVPMIP LATRLLAGASLKDLNPAVQNHHGVAVKFPVFSSHAIQDVDVKLGPEMKSTGEGMCVAY DSNSALKKIYTRVWSQKGSIYLQNVPEDVKELAENAGFTIHEGTFASWMEQEGNSLHI NLSGSEEARKERLEAMTHGIPVFTEEETVRAFLQSGSGHPQPVSLKDLYKKEVASCTQ *" /label="carB CDS" gene 1149952..1153044 /gene="carB" /locus_tag="BSU_11240" /old_locus_tag="BSU11240" /label="carB gene" CDS 1153032..1153991 /gene="argF" /locus_tag="BSU_11250" /old_locus_tag="BSU11250" /EC_number="2.1.3.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:3099126, 6409881, 8025667, 9346304, 16585758, 26443366" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3099126, 6409881, 8025667, 9346304, 16585758, 26443366; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ornithine carbamoyltransferase" /protein_id="NP_389007.1" /db_xref="EnsemblGenomes-Gn:BSU11250" /db_xref="EnsemblGenomes-Tr:CAB12966" /db_xref="GOA:P18186" /db_xref="InterPro:IPR002292" /db_xref="InterPro:IPR006130" /db_xref="InterPro:IPR006131" /db_xref="InterPro:IPR006132" /db_xref="InterPro:IPR024904" /db_xref="InterPro:IPR036901" /db_xref="SubtiList:BG10197" /db_xref="UniProtKB/Swiss-Prot:P18186" /translation="MHTVTQTSLYGKDLLTLKDLSEEDINALLAEAGELKQNKIQPIF HGKTLAMIFEKSSTRTRVSFEAGMAQLGGSALFLSQKDLQLGRGETVADTAKVLSGYV DAIMIRTFEHEKVEELAKEADIPVINGLTDKYHPCQALADLLTIKEIKGKLKGVKVAY IGDGNNVAHSLMIGCAKMGCDISIASPKGYEVLDEAAEAAKTYALQSGSSVTLTDDPI EAVKDADVIYSDVFTSMGQEAEEQERLAVFAPYQVNAALVSHAKPDYTFLHCLPAHRE EEVTAEIIDGPNSAVFQQAENRLHVQKALLKAILYKGESSKNC*" /label="argF CDS" gene 1153032..1153991 /gene="argF" /locus_tag="BSU_11250" /old_locus_tag="BSU11250" /label="argF gene" downshifts 1153954 /Source="Nicolas_upshifts" /id="D609" /incds=0 /nref=141 /ntot=268 /MaxReadThrough="4.29547" /MaxDrop="7.69347" /score="22.2660758" /energy="-11.1" /TU="U899" /idTUdmin="U899" /TUdmin="-305" /isTUend="FALSE" /label="downshifts" S_feature complement(1153994..1154268) /Source="Nicolas_S_feature" /locus_tag="new_1204423_1204697_c" /HighExp="G135, G180, Cold, LBGexp, G150, B60, LoTm, Paraq, Oxctl, H2O2" /AntisenseName="yjzC" /AntisenseCor="-0.37122740772860502" /AntisenseRegPval="-9.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S399" promotor_-35 1154019..1154025 /Source="Nicolas_upshift_promotors" /id="U901" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=943 /SigmaFactorBS="agcagtttttttgatggcAACATATtcacagccgcttagGCG CATACTACAgcaaaaaggaaaaggaggaaaaacagtgggacagcagcaccaattccgg c" /listShort="yjzC" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(1154027) /Source="Nicolas_upshifts" /id="D610" /incds=0 /nref=33 /ntot=166 /MaxReadThrough="1.19008" /MaxDrop="5.22155" /score="16.2777759" /energy="-11.2" /TU="NA" /idTUdmin="U902" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 1154040..1154051 /Source="Nicolas_upshift_promotors" /id="U901" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=943 /SigmaFactorBS="agcagtttttttgatggcAACATATtcacagccgcttagGCG CATACTACAgcaaaaaggaaaaggaggaaaaacagtgggacagcagcaccaattccgg c" /listShort="yjzC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1154061 /Source="Nicolas_upshifts" /id="U901" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=943 /SigmaFactorBS="agcagtttttttgatggcAACATATtcacagccgcttagGCG CATACTACAgcaaaaaggaaaaggaggaaaaacagtgggacagcagcaccaattccgg c" /listShort="yjzC" /GFF_Attribute="listLong" /label="upshifts" CDS 1154077..1154256 /gene="yjzC" /locus_tag="BSU_11260" /old_locus_tag="BSU11260" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 25859258" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389008.1" /db_xref="EnsemblGenomes-Gn:BSU11260" /db_xref="EnsemblGenomes-Tr:CAB12967" /db_xref="InterPro:IPR025549" /db_xref="SubtiList:BG13223" /db_xref="UniProtKB/Swiss-Prot:O34585" /translation="MGQQHQFRPGQKAPNNGVYVEIGETGSMVKNPQKVHLSAGEMFP ETSNHNRLWTYKRKP*" /label="yjzC CDS" gene 1154077..1154256 /gene="yjzC" /locus_tag="BSU_11260" /old_locus_tag="BSU11260" /label="yjzC gene" downshifts 1154266 /Source="Nicolas_upshifts" /id="D611" /incds=0 /nref=19 /ntot=53 /MaxReadThrough="0.25116" /MaxDrop="5.67653" /score="4.8153862" /energy="-10.9" /TU="NA" /idTUdmin="U899" /TUdmin=7 /isTUend="TRUE" /label="downshifts" CDS complement(1154302..1154487) /gene="yjzD" /locus_tag="BSU_11270" /old_locus_tag="BSU11270" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:19775244" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19775244; Product type f: factor" /codon_start=1 /transl_table=11 /product="forespore targeted protein" /protein_id="NP_389009.1" /db_xref="EnsemblGenomes-Gn:BSU11270" /db_xref="EnsemblGenomes-Tr:CAB12968" /db_xref="GOA:O34713" /db_xref="InterPro:IPR021324" /db_xref="SubtiList:BG13224" /db_xref="UniProtKB/Swiss-Prot:O34713" /translation="MRYIIAFIWTFLLSHMACYLVASMNSVTYNFKTSSVIAVVLYVL IMVLAEIMPMNKNASQH*" /label="yjzD CDS" gene complement(1154302..1154487) /gene="yjzD" /locus_tag="BSU_11270" /old_locus_tag="BSU11270" /label="yjzD gene" downshifts complement(1154313) /Source="Nicolas_upshifts" /id="D612" /incds=0 /nref=215 /ntot=261 /MaxReadThrough="3.91391" /MaxDrop="6.26103" /score="9.62656276" /energy="-10.9" /TU="U902" /idTUdmin="U902" /TUdmin="-286" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1154516..1154535) /Source="Nicolas_upshift_promotors" /id="U902" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.94005994005994" /psig=1 /xcortree=3093 /SigmaFactorBS="atcagactcttttgtcacctcactttctgctaaaattggaTT CCCCCTtcgctttttgTATGGTATGATAACTTTTAGaatagaatgagaaggacgaggt g" /listShort="yjzD, S399" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1154533) /Source="Nicolas_upshifts" /id="U902" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.94005994005994" /psig=1 /xcortree=3093 /SigmaFactorBS="atcagactcttttgtcacctcactttctgctaaaattggaTT CCCCCTtcgctttttgTATGGTATGATAACTTTTAGaatagaatgagaaggacgaggt g" /listShort="yjzD, S399" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1154546..1154553) /Source="Nicolas_upshift_promotors" /id="U902" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.94005994005994" /psig=1 /xcortree=3093 /SigmaFactorBS="atcagactcttttgtcacctcactttctgctaaaattggaTT CCCCCTtcgctttttgTATGGTATGATAACTTTTAGaatagaatgagaaggacgaggt g" /listShort="yjzD, S399" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1154588..1154594 /Source="Nicolas_upshift_promotors" /id="U903" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.972027972027972" /psig=1 /xcortree=3055 /SigmaFactorBS="gaatccaattttagcagaaagtgaggtgacaaaagagTCTGA TTcgtcacactttAATGGTAAAATATAAAACGTcaatcagtataatagccaaaaatgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1154606..1154625 /Source="Nicolas_upshift_promotors" /id="U903" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.972027972027972" /psig=1 /xcortree=3055 /SigmaFactorBS="gaatccaattttagcagaaagtgaggtgacaaaagagTCTGA TTcgtcacactttAATGGTAAAATATAAAACGTcaatcagtataatagccaaaaatgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1154611 /Source="Nicolas_upshifts" /id="U903" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.972027972027972" /psig=1 /xcortree=3055 /SigmaFactorBS="gaatccaattttagcagaaagtgaggtgacaaaagagTCTGA TTcgtcacactttAATGGTAAAATATAAAACGTcaatcagtataatagccaaaaatgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1154668..1154677 /Source="Nicolas_upshift_promotors" /id="U904" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1435 /SigmaFactorBS="ataaaacgtcaatcagtataatagccaaaaatgtaaaaggct aggactttaCCTTATTCGTttcttttctattTACATAAGATAGCGTGAGATgaagtgt g" /listShort="yjaU, yjaV, med" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1154677 /Source="Nicolas_upshifts" /id="U904" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1435 /SigmaFactorBS="ataaaacgtcaatcagtataatagccaaaaatgtaaaaggct aggactttaCCTTATTCGTttcttttctattTACATAAGATAGCGTGAGATgaagtgt g" /listShort="yjaU, yjaV, med" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1154690..1154709 /Source="Nicolas_upshift_promotors" /id="U904" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1435 /SigmaFactorBS="ataaaacgtcaatcagtataatagccaaaaatgtaaaaggct aggactttaCCTTATTCGTttcttttctattTACATAAGATAGCGTGAGATgaagtgt g" /listShort="yjaU, yjaV, med" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1154736..1155470 /gene="yjaU" /locus_tag="BSU_11280" /old_locus_tag="BSU11280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 18582593" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389010.1" /db_xref="EnsemblGenomes-Gn:BSU11280" /db_xref="EnsemblGenomes-Tr:CAB12969" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG13124" /db_xref="UniProtKB/Swiss-Prot:O35001" /translation="MGITERYFQLGTEHNVIHLPYRPNGFGIFILGDRTHFVGHDSSF WQQHYGRNQLLSMLMNEGYTLFNSNLFGRHWGAEKAVTYAKQLIHSVLKQEILNPKIH ILAEGMGALVADELLRFSPDHIRSAAMLNPCLDLQAHYESEKENKFFYKQFLKEVSKS YGISEKEAEAIRYKTIQSYPSGVPVHIWQRMTGAPYPYSVHAEVFKEKQQKQGSPVDM TFHLFEHPSRIYASICKFFHSHEKEL*" /label="yjaU CDS" gene 1154736..1155470 /gene="yjaU" /locus_tag="BSU_11280" /old_locus_tag="BSU11280" /label="yjaU gene" S_feature complement(1155229..1155831) /Source="Nicolas_S_feature" /locus_tag="new_1205658_1206260_c" /HighExp="S8, S6, S7, C30, BT, S4, S5, Pyr, S3, C90" /AntisenseName="yjaV" /AntisenseCor="0.66207512383157796" /AntisenseRegPval="-34.6" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.468" /TUlongSig="NA" /TUlongPSig="NA" /label="S400" promotor_-35 1155451..1155456 /Source="Nicolas_upshift_promotors" /id="U905" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1036 /SigmaFactorBS="atccaagcagaatttatgcatcaatttgcaaattctttcata GTCATGaaaaagaattatagaGAATATAATGACAACAGCCttctcttttgcggaggct g" /listShort="yjaV, med, comZ" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1155469 /Source="Nicolas_upshifts" /id="D613" /incds=0 /nref=6 /ntot=47 /MaxReadThrough="5.56163" /MaxDrop="4.5381" /score="1.90624641" /energy="-10" /TU="U904,U905" /idTUdmin="U904" /TUdmin="-945" /isTUend="FALSE" /label="downshifts" upshifts 1155469 /Source="Nicolas_upshifts" /id="U905" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1036 /SigmaFactorBS="atccaagcagaatttatgcatcaatttgcaaattctttcata GTCATGaaaaagaattatagaGAATATAATGACAACAGCCttctcttttgcggaggct g" /listShort="yjaV, med, comZ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1155472..1155490 /Source="Nicolas_upshift_promotors" /id="U905" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1036 /SigmaFactorBS="atccaagcagaatttatgcatcaatttgcaaattctttcata GTCATGaaaaagaattatagaGAATATAATGACAACAGCCttctcttttgcggaggct g" /listShort="yjaV, med, comZ" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1155552..1156109 /gene="yjaV" /locus_tag="BSU_11290" /old_locus_tag="BSU11290" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14523133; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NAD(P) binding enzyme" /protein_id="NP_389011.2" /db_xref="EnsemblGenomes-Gn:BSU11290" /db_xref="EnsemblGenomes-Tr:CAB12970" /db_xref="SubtiList:BG13125" /db_xref="UniProtKB/Swiss-Prot:O34959" /translation="MESTLIVGADEFFGLSLCERMMDEGIHVDVVLAETEDKMRQMYL EERLMWLGRNELFRQLEHIGDQNYDTICIQFGSFLPLDQYDSPYILVYEEDRKEWDKR EKTGSEKTVILPKMYGPWKEETEEDGYYTNDVADELLRFLLEPSRHSKDQLFELQVTE KTSKEEAKTKIIEWKRQFSSIFDKY*" /label="yjaV CDS" gene 1155552..1156109 /gene="yjaV" /locus_tag="BSU_11290" /old_locus_tag="BSU11290" /label="yjaV gene" promotor_-10 complement(1155811..1155830) /Source="Nicolas_upshift_promotors" /id="U906" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.467532467532468" /psig="0.467532467532468" /xcortree=771 /SigmaFactorBS="gcaggatcacggttttttccgagcctgttttttcacgtttat CCCATtcttttcggtcttcTTCATATACTAAAATATAAGgagaatcatattggtctaa a" /listShort="S400" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1155831) /Source="Nicolas_upshifts" /id="U906" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.467532467532468" /psig="0.467532467532468" /xcortree=771 /SigmaFactorBS="gcaggatcacggttttttccgagcctgttttttcacgtttat CCCATtcttttcggtcttcTTCATATACTAAAATATAAGgagaatcatattggtctaa a" /listShort="S400" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1155845..1155849) /Source="Nicolas_upshift_promotors" /id="U906" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.467532467532468" /psig="0.467532467532468" /xcortree=771 /SigmaFactorBS="gcaggatcacggttttttccgagcctgttttttcacgtttat CCCATtcttttcggtcttcTTCATATACTAAAATATAAGgagaatcatattggtctaa a" /listShort="S400" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1156116..1156123 /Source="Nicolas_upshift_promotors" /id="U907" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.689310689310689" /psig=1 /xcortree=2121 /SigmaFactorBS="caattttcgacaaatattaagaaaaaCCTTCCATgtttcgag ttttctAGATACAATAAACGTATAAAaataatacatgttatagcttgtcaaaaggagt t" /listShort="med, comZ, S401" /listLong="fabHA, fabF" /label="promotor_-35" promotor_-10 1156138..1156157 /Source="Nicolas_upshift_promotors" /id="U907" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.689310689310689" /psig=1 /xcortree=2121 /SigmaFactorBS="caattttcgacaaatattaagaaaaaCCTTCCATgtttcgag ttttctAGATACAATAAACGTATAAAaataatacatgttatagcttgtcaaaaggagt t" /listShort="med, comZ, S401" /listLong="fabHA, fabF" /label="promotor_-10" upshifts 1156150 /Source="Nicolas_upshifts" /id="U907" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.689310689310689" /psig=1 /xcortree=2121 /SigmaFactorBS="caattttcgacaaatattaagaaaaaCCTTCCATgtttcgag ttttctAGATACAATAAACGTATAAAaataatacatgttatagcttgtcaaaaggagt t" /listShort="med, comZ, S401" /listLong="fabHA, fabF" /label="upshifts" CDS 1156200..1157153 /gene="med" /locus_tag="BSU_11300" /old_locus_tag="BSU11300" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1203607, 21622736, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1203607, 21622736, 22720735; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="positive regulator of comK" /protein_id="NP_389012.2" /db_xref="EnsemblGenomes-Gn:BSU11300" /db_xref="EnsemblGenomes-Tr:CAB12971" /db_xref="GOA:O32436" /db_xref="InterPro:IPR003760" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG13126" /db_xref="UniProtKB/Swiss-Prot:O32436" /translation="MITRLVMIFSVLLLLSGCGQTPFKGKIEKVGMLFPDTINDLVWG TKGYKGLLNIQSKYNVDVYYKEGVKTEEDIINAIEDFHKRGVNLLYGHGSEYAEVFNL VGEDYPDMEFVISNAKAKADNVTSVHFSGEAMGFFGGMTAAHMSKTNQVGVIASFTWQ PEVDGFIKGAKYENPDIEVNTKYTDHWDDDTTAVKLYQKMKNEGADVVYPAGDGYNVP VIQQIKKDGLYAIGYVTDQSDLGENTVLTSTVQNVDKAYEIIAEQFNKGTLEGGDHYY DLNTGVVEMGTFSPLVDQDFQQRIAKLIKTYNKTGELPKNE*" /label="med CDS" gene 1156200..1157153 /gene="med" /locus_tag="BSU_11300" /old_locus_tag="BSU11300" /label="med gene" promotor_-35 1156817..1156821 /Source="Nicolas_upshift_promotors" /id="U908" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=1825 /SigmaFactorBS="tcagaaaatgaagaacgaaggcgcggaTGTTGtgtatcccgc cggagACGGGTATAATGTTCCTGTTattcagcaaatcaaaaaagacggtctttatgcc a" /listShort="comZ, S401" /listLong="fabHA, fabF" /label="promotor_-35" promotor_-10 1156837..1156856 /Source="Nicolas_upshift_promotors" /id="U908" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=1825 /SigmaFactorBS="tcagaaaatgaagaacgaaggcgcggaTGTTGtgtatcccgc cggagACGGGTATAATGTTCCTGTTattcagcaaatcaaaaaagacggtctttatgcc a" /listShort="comZ, S401" /listLong="fabHA, fabF" /label="promotor_-10" upshifts 1156850 /Source="Nicolas_upshifts" /id="U908" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=1825 /SigmaFactorBS="tcagaaaatgaagaacgaaggcgcggaTGTTGtgtatcccgc cggagACGGGTATAATGTTCCTGTTattcagcaaatcaaaaaagacggtctttatgcc a" /listShort="comZ, S401" /listLong="fabHA, fabF" /label="upshifts" CDS 1157168..1157359 /gene="comZ" /locus_tag="BSU_11310" /old_locus_tag="BSU11310" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10940045; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative late competence gene" /protein_id="NP_389013.1" /db_xref="EnsemblGenomes-Gn:BSU11310" /db_xref="EnsemblGenomes-Tr:CAB12972" /db_xref="GOA:O32437" /db_xref="InterPro:IPR024558" /db_xref="SubtiList:BG13221" /db_xref="UniProtKB/Swiss-Prot:O32437" /translation="MQHEKSLEFLQIAMKYLPEAKEQLEKSGIELSMEAIQPFMNLFT TVMAEAYELGKSDAKSETE*" /label="comZ CDS" gene 1157168..1157359 /gene="comZ" /locus_tag="BSU_11310" /old_locus_tag="BSU11310" /label="comZ gene" downshifts 1157338 /Source="Nicolas_upshifts" /id="D614" /incds=0 /nref=32 /ntot=192 /MaxReadThrough="4.56858" /MaxDrop="3.45953" /score="-7.49795364" /energy="-10.4" /TU="U907,U908" /idTUdmin="U905" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 1157383..1157723 /Source="Nicolas_S_feature" /locus_tag="new_1207812_1208152" /HighExp="H2O2, C30, G135, Paraq, G180, G150, Oxctl, Cold, dia15, LPh" /AntisenseName="yjzB" /AntisenseCor="-0.34349942363230701" /AntisenseRegPval="-8.1" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S401" CDS complement(1157389..1157628) /gene="yjzB" /locus_tag="BSU_11320" /old_locus_tag="BSU11320" /experiment="publication(s) with functional evidences, PMID:16391061, 22171814, 27227299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16391061, 22171814, 27227299; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat protein" /protein_id="NP_389014.1" /db_xref="EnsemblGenomes-Gn:BSU11320" /db_xref="EnsemblGenomes-Tr:CAB12973" /db_xref="SubtiList:BG13222" /db_xref="UniProtKB/Swiss-Prot:O34891" /translation="MQLDVFSRMMFGDAAKPTEEKEEEQQEEVSQVSQTNDEETINYM HIMDQIGSIMNSLDQIKPALKELAPMLSAIKKKIM*" /label="yjzB CDS" gene complement(1157389..1157628) /gene="yjzB" /locus_tag="BSU_11320" /old_locus_tag="BSU11320" /label="yjzB gene" downshifts complement(1157405) /Source="Nicolas_upshifts" /id="D615" /incds=0 /nref=21 /ntot=48 /MaxReadThrough="1.43519" /MaxDrop="5.47891" /score="-7.75082002" /energy="-10.4" /TU="NA" /idTUdmin="U909" /TUdmin="-13" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1157641..1157660) /Source="Nicolas_upshift_promotors" /id="U909" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1358 /SigmaFactorBS="ctaattctatcctattttttttcacatggcaatatattcGTC TAAACTAtcagttcatcttaCTCATAGAGTATGGTATATGgaaaggaggcgtatgcag t" /listShort="yjzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1157662) /Source="Nicolas_upshifts" /id="U909" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1358 /SigmaFactorBS="ctaattctatcctattttttttcacatggcaatatattcGTC TAAACTAtcagttcatcttaCTCATAGAGTATGGTATATGgaaaggaggcgtatgcag t" /listShort="yjzB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1157674..1157683) /Source="Nicolas_upshift_promotors" /id="U909" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1358 /SigmaFactorBS="ctaattctatcctattttttttcacatggcaatatattcGTC TAAACTAtcagttcatcttaCTCATAGAGTATGGTATATGgaaaggaggcgtatgcag t" /listShort="yjzB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1157689..1157696 /Source="Nicolas_upshift_promotors" /id="U910" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.858141858141858" /psig=1 /xcortree=2188 /SigmaFactorBS="atgaactgatagtttagacgaataTATTGCCAtgtgaaaaaa aataGGATAGAATTAGTACCTGATactaataattgatcacaacctgattgatcttcta a" /listShort="fabHA, fabF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1157711..1157730 /Source="Nicolas_upshift_promotors" /id="U910" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.858141858141858" /psig=1 /xcortree=2188 /SigmaFactorBS="atgaactgatagtttagacgaataTATTGCCAtgtgaaaaaa aataGGATAGAATTAGTACCTGATactaataattgatcacaacctgattgatcttcta a" /listShort="fabHA, fabF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1157725 /Source="Nicolas_upshifts" /id="U910" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.858141858141858" /psig=1 /xcortree=2188 /SigmaFactorBS="atgaactgatagtttagacgaataTATTGCCAtgtgaaaaaa aataGGATAGAATTAGTACCTGATactaataattgatcacaacctgattgatcttcta a" /listShort="fabHA, fabF" /GFF_Attribute="listLong" /label="upshifts" CDS 1157793..1158731 /gene="fabHA" /locus_tag="BSU_11330" /old_locus_tag="BSU11330" /EC_number="2.3.1.180" /EC_number="2.3.1.38" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10629181, 11959561, 21542858, 25196128" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10629181, 11959561, 21542858, 25196128; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="beta-ketoacyl-acyl carrier protein synthase III 1" /protein_id="NP_389015.1" /db_xref="EnsemblGenomes-Gn:BSU11330" /db_xref="EnsemblGenomes-Tr:CAB12974" /db_xref="GOA:O34746" /db_xref="InterPro:IPR004655" /db_xref="InterPro:IPR013747" /db_xref="InterPro:IPR013751" /db_xref="InterPro:IPR016039" /db_xref="SubtiList:BG13127" /db_xref="UniProtKB/Swiss-Prot:O34746" /translation="MKAGILGVGRYIPEKVLTNHDLEKMVETSDEWIRTRTGIEERRI AADDVFSSHMAVAAAKNALEQAEVAAEDLDMILVATVTPDQSFPTVSCMIQEQLGAKK ACAMDISAACAGFMYGVVTGKQFIESGTYKHVLVVGVEKLSSITDWEDRNTAVLFGDG AGAAVVGPVSDDRGILSFELGADGTGGQHLYLNEKRHTIMNGREVFKFAVRQMGESCV NVIEKAGLSKEDVDFLIPHQANIRIMEAARERLELPVEKMSKTVHKYGNTSAASIPIS LVEELEAGKIKDGDVVVMVGFGGGLTWGAIAIRWGR*" /label="fabHA CDS" gene 1157793..1158731 /gene="fabHA" /locus_tag="BSU_11330" /old_locus_tag="BSU11330" /label="fabHA gene" promotor_-35 1157870..1157879 /Source="Nicolas_upshift_promotors" /id="U911" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=1791 /SigmaFactorBS="tcctgagaaggttttaacaaatcatgatcttgaaaaaatggt TGAAACTTCTgacgagtggatTCGTACAAGAACAGGAatagaagaaagaagaatcgca g" /listShort="fabF" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1157888 /Source="Nicolas_upshifts" /id="U911" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=1791 /SigmaFactorBS="tcctgagaaggttttaacaaatcatgatcttgaaaaaatggt TGAAACTTCTgacgagtggatTCGTACAAGAACAGGAatagaagaaagaagaatcgca g" /listShort="fabF" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1157891..1157906 /Source="Nicolas_upshift_promotors" /id="U911" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=1791 /SigmaFactorBS="tcctgagaaggttttaacaaatcatgatcttgaaaaaatggt TGAAACTTCTgacgagtggatTCGTACAAGAACAGGAatagaagaaagaagaatcgca g" /listShort="fabF" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1158754..1159995 /gene="fabF" /locus_tag="BSU_11340" /old_locus_tag="BSU11340" /EC_number="2.3.1.41" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11325930, 12682299, 16436705, 18384517, 21542858, 28196402" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11325930, 12682299, 16436705, 18384517, 21542858, 28196402; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="beta-ketoacyl-acyl carrier protein synthase II (involved in pimelate synthesis)" /protein_id="NP_389016.1" /db_xref="EnsemblGenomes-Gn:BSU11340" /db_xref="EnsemblGenomes-Tr:CAB12975" /db_xref="GOA:O34340" /db_xref="InterPro:IPR014030" /db_xref="InterPro:IPR014031" /db_xref="InterPro:IPR016039" /db_xref="InterPro:IPR017568" /db_xref="InterPro:IPR018201" /db_xref="InterPro:IPR020841" /db_xref="PDB:4LS5" /db_xref="PDB:4LS6" /db_xref="PDB:4LS7" /db_xref="PDB:4LS8" /db_xref="SubtiList:BG13128" /db_xref="UniProtKB/Swiss-Prot:O34340" /translation="MTKKRVVVTGLGALSPLGNDVDTSWNNAINGVSGIGPITRVDAE EYPAKVAAELKDFNVEDYMDKKEARKMDRFTQYAVVAAKMAVEDADLNITDEIAPRVG VWVGSGIGGLETLESQFEIFLTKGPRRVSPFFVPMMIPDMATGQISIALGAKGVNSCT VTACATGTNSIGDAFKVIQRGDADVMVTGGTEAPLTRMSFAGFSANKALSTNPDPKTA SRPFDKNRDGFVMGEGAGIIVLEELEHALARGAKIYGEIVGYGSTGDAYHITAPAQDG EGGARAMQEAIKDAGIAPEEIDYINAHGTSTYYNDKYETMAIKTVFGEHAHKLAVSST KSMTGHLLGAAGGIEAIFSILAIKEGVIPPTINIQTPDEECDLDYVPDEARRQELNYV LSNSLGFGGHNATLIFKKYQS*" /label="fabF CDS" gene 1158754..1159995 /gene="fabF" /locus_tag="BSU_11340" /old_locus_tag="BSU11340" /label="fabF gene" promotor_-10 complement(1158968..1158986) /Source="Nicolas_upshift_promotors" /id="U912" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.813186813186813" /psig="0.813186813186813" /xcortree=777 /SigmaFactorBS="cggtaatgttaagatctgcatcttcaaccGCCATTttcgcag ccacaaccGCATATTGTGTAAAGCGGTccatttttctggcttcttttttatccatata a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1158976) /Source="Nicolas_upshifts" /id="U912" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.813186813186813" /psig="0.813186813186813" /xcortree=777 /SigmaFactorBS="cggtaatgttaagatctgcatcttcaaccGCCATTttcgcag ccacaaccGCATATTGTGTAAAGCGGTccatttttctggcttcttttttatccatata a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1159002..1159007) /Source="Nicolas_upshift_promotors" /id="U912" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.813186813186813" /psig="0.813186813186813" /xcortree=777 /SigmaFactorBS="cggtaatgttaagatctgcatcttcaaccGCCATTttcgcag ccacaaccGCATATTGTGTAAAGCGGTccatttttctggcttcttttttatccatata a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1159846 /Source="Nicolas_upshifts" /id="D616" /incds=1 /nref=1 /ntot=89 /MaxReadThrough="7.03006" /MaxDrop="2.1101" /score="54.6350161" /energy="-18.5" /TU="U910,U911" /idTUdmin="U911" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" downshifts 1159979 /Source="Nicolas_upshifts" /id="D617" /incds=0 /nref=246 /ntot=274 /MaxReadThrough="0.58964" /MaxDrop="7.80446" /score="54.6350161" /energy="-18.5" /TU="NA" /idTUdmin="U911" /TUdmin=1 /isTUend="TRUE" /label="downshifts" promotor_-35 1160020..1160029 /Source="Nicolas_upshift_promotors" /id="U913" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1338 /SigmaFactorBS="tatcaatcataatcaagccaaaccggctgcccttaaAGGGTA GCCGgttttttttgtgTGCATAGGATTAAAAGAGGAggcgatcacatgagtgtagaac a" /listShort="yjaZ, S402, S403, appD, appF" /listLong="S404, appA, appA, appB, appC" /label="promotor_-35" promotor_-10 1160042..1160061 /Source="Nicolas_upshift_promotors" /id="U913" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1338 /SigmaFactorBS="tatcaatcataatcaagccaaaccggctgcccttaaAGGGTA GCCGgttttttttgtgTGCATAGGATTAAAAGAGGAggcgatcacatgagtgtagaac a" /listShort="yjaZ, S402, S403, appD, appF" /listLong="S404, appA, appA, appB, appC" /label="promotor_-10" upshifts 1160044 /Source="Nicolas_upshifts" /id="U913" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1338 /SigmaFactorBS="tatcaatcataatcaagccaaaccggctgcccttaaAGGGTA GCCGgttttttttgtgTGCATAGGATTAAAAGAGGAggcgatcacatgagtgtagaac a" /listShort="yjaZ, S402, S403, appD, appF" /listLong="S404, appA, appA, appB, appC" /label="upshifts" promotor_-35 1160056..1160064 /Source="Nicolas_upshift_promotors" /id="U914" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=544 /SigmaFactorBS="cggttttttttgtgtgcataggattaaaAGAGGAGGCgatca catgagTGTAGAACAAACATATAGCtggctcaggaaggccggttcaatagatgatttg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1160071..1160856 /gene="yjaZ" /locus_tag="BSU_11350" /old_locus_tag="BSU11350" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389017.1" /db_xref="EnsemblGenomes-Gn:BSU11350" /db_xref="EnsemblGenomes-Tr:CAB12992" /db_xref="InterPro:IPR018728" /db_xref="SubtiList:BG13129" /db_xref="UniProtKB/Swiss-Prot:O31596" /translation="MSVEQTYSWLRKAGSIDDLAHYIIPLFSGAEKKNWKGILGHLQH HGMFKNIKEGIQTVSKLKEKGFYGHIQKEEQYLKNKWQGPDVPIVTLPVDERNRRIRL EFGSKSGLAFQDKMFLFLSSDLDFGSVSALMTHEYHHVCRLGHLTKEEKDVTLLDTII MEGLAEYAVYERFGRSQTAEWTTWYTPEQLQALYEKKIAPHRDIKRDNRLFPQLLFGK GYQPKMLGYAVGFNIVKKYLTASKASTADGLSIPAETFLDAML*" /label="yjaZ CDS" gene 1160071..1160856 /gene="yjaZ" /locus_tag="BSU_11350" /old_locus_tag="BSU11350" /label="yjaZ gene" promotor_-10 1160076..1160094 /Source="Nicolas_upshift_promotors" /id="U914" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=544 /SigmaFactorBS="cggttttttttgtgtgcataggattaaaAGAGGAGGCgatca catgagTGTAGAACAAACATATAGCtggctcaggaaggccggttcaatagatgatttg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1160088 /Source="Nicolas_upshifts" /id="U914" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=544 /SigmaFactorBS="cggttttttttgtgtgcataggattaaaAGAGGAGGCgatca catgagTGTAGAACAAACATATAGCtggctcaggaaggccggttcaatagatgatttg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature 1160857..1160941 /Source="Nicolas_S_feature" /locus_tag="new_1211286_1211370" /HighExp="S6, S5, S8, S7, BT, S4, S3, B36, T5.0H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S402" promotor_-10 complement(1160873..1160891) /Source="Nicolas_upshift_promotors" /id="U915" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.838161838161838" /psig="0.838161838161838" /xcortree=1001 /SigmaFactorBS="tttatagttgtatattattacaatcattttgcaaaatcaAGA ATTttttaggataaatgTAATATTATTAATGAAATTccattattttatccttttaaag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1160890) /Source="Nicolas_upshifts" /id="U915" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.838161838161838" /psig="0.838161838161838" /xcortree=1001 /SigmaFactorBS="tttatagttgtatattattacaatcattttgcaaaatcaAGA ATTttttaggataaatgTAATATTATTAATGAAATTccattattttatccttttaaag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1160906..1160911) /Source="Nicolas_upshift_promotors" /id="U915" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.838161838161838" /psig="0.838161838161838" /xcortree=1001 /SigmaFactorBS="tttatagttgtatattattacaatcattttgcaaaatcaAGA ATTttttaggataaatgTAATATTATTAATGAAATTccattattttatccttttaaag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1160909..1160916 /Source="Nicolas_upshift_promotors" /id="U916" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98001998001998" /psig="0.999000999001" /xcortree=2876 /SigmaFactorBS="ataatattacatttatcctaaaaaatTCTTGATTttgcaaaa tgattgTAATAATATACAACTATAAAatttttcgataattcaatattatttattattt c" /listShort="S403, appD, appF, S404, appA, appA, appB, appC, S405, yjbA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1160931..1160950 /Source="Nicolas_upshift_promotors" /id="U916" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98001998001998" /psig="0.999000999001" /xcortree=2876 /SigmaFactorBS="ataatattacatttatcctaaaaaatTCTTGATTttgcaaaa tgattgTAATAATATACAACTATAAAatttttcgataattcaatattatttattattt c" /listShort="S403, appD, appF, S404, appA, appA, appB, appC, S405, yjbA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1160943..1161047 /Source="Nicolas_S_feature" /locus_tag="new_1211372_1211476" /HighExp="LoTm, T4.0H, T3.0H, T5.0H, T3.30H, T2.30H, M9-stat, S1, T2.0H, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S403" upshifts 1160943 /Source="Nicolas_upshifts" /id="U916" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98001998001998" /psig="0.999000999001" /xcortree=2876 /SigmaFactorBS="ataatattacatttatcctaaaaaatTCTTGATTttgcaaaa tgattgTAATAATATACAACTATAAAatttttcgataattcaatattatttattattt c" /listShort="S403, appD, appF, S404, appA, appA, appB, appC, S405, yjbA" /GFF_Attribute="listLong" /label="upshifts" CDS 1161048..1162034 /gene="appD" /locus_tag="BSU_11360" /old_locus_tag="BSU11360" /EC_number="3.6.3.-" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7997159, 25755103, 26728191" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7997159, 25755103, 26728191; Product type t: transporter" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (ATP-binding protein)" /protein_id="NP_389018.1" /db_xref="EnsemblGenomes-Gn:BSU11360" /db_xref="EnsemblGenomes-Tr:CAB12993" /db_xref="GOA:P42064" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR013563" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11085" /db_xref="UniProtKB/Swiss-Prot:P42064" /translation="MSTLLEVNNLKTYFFRKKEPIPAVDGVDFHISKGETVALVGESG SGKSITSLSIMGLVQSSGGKIMDGSIKLEDKDLTSFTENDYCKIRGNEVSMIFQEPMT SLNPVLTIGEQITEVLIYHKNMKKKEARQRAVELLQMVGFSRAEQIMKEYPHRLSGGM RQRVMIAIALSCNPKLLIADEPTTALDVTIQAQVLELMKDLCQKFNTSILLITHDLGV VSEAADRVIVMYCGQVVENATVDDLFLEPLHPYTEGLLTSIPVIDGEIDKLNAIKGSV PTPDNLPPGCRFAPRCPKAMDKCWTNQPSLLTHKSGRTVRCFLYEEEGAEQS*" /label="appD CDS" gene 1161048..1162034 /gene="appD" /locus_tag="BSU_11360" /old_locus_tag="BSU11360" /label="appD gene" CDS 1162031..1163020 /gene="appF" /locus_tag="BSU_11370" /old_locus_tag="BSU11370" /EC_number="3.6.3.-" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7997159, 25755103, 26728191, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7997159, 25755103, 26728191, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (ATP-binding protein)" /protein_id="NP_389019.2" /db_xref="EnsemblGenomes-Gn:BSU11370" /db_xref="EnsemblGenomes-Tr:CAB12994" /db_xref="GOA:P42065" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR013563" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11086" /db_xref="UniProtKB/Swiss-Prot:P42065" /translation="MTAANQETILELRDVKKYFPIRSGLFQRKVGDVKAVDGVSFSLK KGETLGIVGESGCGKSTAGRTMIRLYKPTEGQILFKGQDISNLSEEKLRKSVRKNIQM VFQDPFASLNPRKTLRSIIKEPFNTHNMYTMRERNEKVEELLARVGLHPSFAGRYPHE FSGGQRQRIGIARALTLNPELIIADEPVSALDVSIQAQVINLMEELQEEFNLTYLFIS HDLSVVRHISDRVGVMYLGKMMELTGKHELYDNPLHPYTQALLSSVPVTRKRGSVKRE RIVLKGELPSPANPPKGCVFHTRCPVAKPICKEQIPEFKEAAPSHFVACHLYS*" /label="appF CDS" gene 1162031..1163020 /gene="appF" /locus_tag="BSU_11370" /old_locus_tag="BSU11370" /label="appF gene" misc_feature 1163026..1163032 /Source="Nicolas_upshift_promotors" /id="U917" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.375624375624376" /psig="0.062937062937063" /xcortree=2877 /SigmaFactorBS="ttaaagaagctgctcccagccactttgtggcttgtcaccttt atagctaatgttgCCCGCACagctttgagagggggtatgcacactacataaacaacag c" /listShort="S404, appA, appA, appB, appC, S405, yjbA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 1163031..1163107 /Source="Nicolas_S_feature" /locus_tag="new_1213460_1213536" /HighExp="T2.0H, S1, M9-stat, T5.0H, T3.0H, T1.30H, S2, M0t90, T2.30H, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.0629, 0.999" /TUlongSig="SigK" /TUlongPSig=1 /label="S404" upshifts 1163031 /Source="Nicolas_upshifts" /id="U917" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.375624375624376" /psig="0.062937062937063" /xcortree=2877 /SigmaFactorBS="ttaaagaagctgctcccagccactttgtggcttgtcaccttt atagctaatgttgCCCGCACagctttgagagggggtatgcacactacataaacaacag c" /listShort="S404, appA, appA, appB, appC, S405, yjbA" /GFF_Attribute="listLong" /label="upshifts" CDS 1163108..1163599 /gene="appAn" /locus_tag="BSU_11381" /old_locus_tag="BSU11381" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 15588833, 25355936; Product type rc: receptor" /pseudo /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (oligopeptide-binding lipoprotein); N-terminal part of AppA" /translation="MKRRKTALMMLSVLMVLAIFLSACSGSKSSNSSAKKSAGKPQQG GDLVVGSIGEPTLFNSLYSTDDASTDIENMLYSFLTKTDEKLNVKLSLAESIKELDGG LAYDVKIKKGVKFHDGKELTADDVVFTYSVPLSKDYKGERGSTYEMLKSVEKKAITKS CLS*" /label="appAn CDS" gene 1163108..1163599 /gene="appAn" /locus_tag="BSU_11381" /old_locus_tag="BSU11381" /pseudo /label="appAn gene" CDS 1163572..1164738 /gene="appAc" /locus_tag="BSU_11382" /old_locus_tag="BSU11382" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId: 7997159, 15588833, 26728191; Product type lp: lipoprotein" /pseudo /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (oligopeptide-binding lipoprotein); C-terminal part of AppA" /translation="GDYEVLFKLKYKDGNFYNNALDSTAILPKHILGNVPIADLEENE FNRKKPIGSGPFKFKEWKQGQYIKLEANDDYFEGRPYLDTVTYKVIPDANAAVAQLQA GDINFFNVPATDYKTAEKFNNLKIVTDLALSYVYIGWNEKNELFKDKKVRQALTTALD RESIVSQVLDGDGEVAYIPESPLSWNYPKDIDVPKFEYNEKKAKQMLAEAGWKDTNGD GILDKDGKKFSFTLKTNQGNKVREDIAVVVQEQLKKIGIEVKTQIVEWSALVEQMNPP NWDFDAMVMGWSLSTFPDQYDIFHSSQIKKGLNYVWYKNAEADKLMKDAKSISDRKQY SKEYEQIYQKIAEDQPYTFLYYPNNHMAMPENLEGYKYHPKRDLYNIEKWWLAK*" /label="appAc CDS" gene 1163572..1164738 /gene="appAc" /locus_tag="BSU_11382" /old_locus_tag="BSU11382" /pseudo /label="appAc gene" downshifts 1164729 /Source="Nicolas_upshifts" /id="D618" /incds=0 /nref=1 /ntot=49 /MaxReadThrough="7.71397" /MaxDrop="3.11667" /score="-1.00317393" /energy="-13.3" /TU="U916,U917" /idTUdmin="U913" /TUdmin=1715 /isTUend="FALSE" /label="downshifts" CDS 1164814..1165764 /gene="appB" /locus_tag="BSU_11390" /old_locus_tag="BSU11390" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7997159, 15849754, 16850406, 26728191" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7997159, 15849754, 16850406, 26728191; Product type t: transporter" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (permease)" /protein_id="NP_389021.2" /db_xref="EnsemblGenomes-Gn:BSU11390" /db_xref="EnsemblGenomes-Tr:CAB12996" /db_xref="GOA:P42062" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11088" /db_xref="UniProtKB/Swiss-Prot:P42062" /translation="MAAYIIRRTLMSIPILLGITILSFVIMKAAPGDPMTLMMDPKIS QADREQFIEKYGLNDPQYVQYLKWLGNMVQGDFGTSIVRKGTPVSELIMARLPNTLLL MLVSTILALMISIPFGVLSAKRPYSKIDYGITFTSFIGLAIPNFWFGLILIMVLSVNL GWFPTGGVETLNTEFNIFDRIHHLILPAFVLATADMAGLTRYTRSNMLDVLNQDYIRT ARAKGFKENRVLFKHGLRNALLPVITIFGLMIPSFIGGSVVVEQIFTWPGLGKLFVDS AFQRDYPVIMAMTVISAVLVVVGNLIADILYAIVDPRIEY*" /label="appB CDS" gene 1164814..1165764 /gene="appB" /locus_tag="BSU_11390" /old_locus_tag="BSU11390" /label="appB gene" CDS 1165781..1166692 /gene="appC" /locus_tag="BSU_11400" /old_locus_tag="BSU11400" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7997159, 15849754, 16850406, 26728191" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7997159, 15849754, 16850406, 26728191; Product type t: transporter" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (permease)" /protein_id="NP_389022.1" /db_xref="EnsemblGenomes-Gn:BSU11400" /db_xref="EnsemblGenomes-Tr:CAB12997" /db_xref="GOA:P42063" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR025966" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11089" /db_xref="UniProtKB/Swiss-Prot:P42063" /translation="MSELQTTPSPEIRLKENISKKPETMTKIFWEKFSKNKLAILGAV ILFIIIMSAVFAPLIAPYPQEQQSLLDKYKAPGLEHLMGTDKFGRDIFSRILYGARVS LLVGFASVVGSILIGTVLGALAGYFRGIVDAVIMRVVDIVLSIPDIFLLITLVTIFKP GVDKLILIFCLTGWTTTARLVRGEFLSLRSREYVLAAKTIGTKTHKIIFSHILPNALG PIIVSATLKVGSVILAESALSYLGFGIQPPIASWGNMLQDAQNFTVMIQAWWYPLFPG LFILMTVLCFNFVGDGLRDALDPKNIK*" /label="appC CDS" gene 1165781..1166692 /gene="appC" /locus_tag="BSU_11400" /old_locus_tag="BSU11400" /label="appC gene" downshifts 1166706 /Source="Nicolas_upshifts" /id="D619" /incds=0 /nref=62 /ntot=188 /MaxReadThrough="5.13927" /MaxDrop="5.50153" /score="22.0028545" /energy="-11.6" /TU="U916,U917" /idTUdmin="U916" /TUdmin="-923" /isTUend="FALSE" /label="downshifts" S_feature 1166751..1166858 /Source="Nicolas_S_feature" /locus_tag="new_1217180_1217287" /HighExp="LoTm, S1, S2, BT, T3.30H, T4.0H, T5.0H, T3.0H, Glu, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.0629, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S405" promotor_-35 1166831..1166836 /Source="Nicolas_upshift_promotors" /id="U918" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1160 /SigmaFactorBS="cccagtgattccagatttcctcaatctctttGGAATAatttc tctatcccttGCCTATACTGTGGACAACAgtttttataaaagtgaggggttagagatg t" /listShort="yjbA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1166852..1166870 /Source="Nicolas_upshift_promotors" /id="U918" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1160 /SigmaFactorBS="cccagtgattccagatttcctcaatctctttGGAATAatttc tctatcccttGCCTATACTGTGGACAACAgtttttataaaagtgaggggttagagatg t" /listShort="yjbA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1166860 /Source="Nicolas_upshifts" /id="U918" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1160 /SigmaFactorBS="cccagtgattccagatttcctcaatctctttGGAATAatttc tctatcccttGCCTATACTGTGGACAACAgtttttataaaagtgaggggttagagatg t" /listShort="yjbA" /GFF_Attribute="listLong" /label="upshifts" CDS 1166897..1167649 /gene="yjbA" /locus_tag="BSU_11410" /old_locus_tag="BSU11410" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11717292, 22882546; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative sporulation nucleic acid binding protein" /protein_id="NP_389023.1" /db_xref="EnsemblGenomes-Gn:BSU11410" /db_xref="EnsemblGenomes-Tr:CAB12998" /db_xref="InterPro:IPR020909" /db_xref="SubtiList:BG13130" /db_xref="UniProtKB/Swiss-Prot:O31597" /translation="MLFLHDVWVNWFEGEENGYNVCHFHEWRKEDTVELLDQVPLLRV PSVLFHYIENDLSELPKGLLEDVHQKSYIRKNHERTKLEYCFVVTDGIGILAVDTIGY TIPVRKSRLIPRQEQLVYEMVKDVEPETYEFEPKKLESSKEYHILSLAPEHVRGLTRK ERQIKQLMFMALDQLKGLKNRAEIGYWYTEWNPHMYEQIKRMSFEEIWDMLYNETIEG WSDKHLAFCENLIKGQPFFEKLWEMENESKVN*" /label="yjbA CDS" gene 1166897..1167649 /gene="yjbA" /locus_tag="BSU_11410" /old_locus_tag="BSU11410" /label="yjbA gene" downshifts 1167629 /Source="Nicolas_upshifts" /id="D620" /incds=0 /nref=32 /ntot=112 /MaxReadThrough="1.07428" /MaxDrop="6.2264" /score="22.0028545" /energy="-11.6" /TU="NA" /idTUdmin="U916" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1167684..1168676) /gene="trpS" /locus_tag="BSU_11420" /old_locus_tag="BSU11420" /EC_number="6.1.1.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8950174, 10706627, 12682299, 24572018" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8950174, 10706627, 12682299, 24572018; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tryptophanyl-tRNA synthetase" /protein_id="NP_389024.1" /db_xref="EnsemblGenomes-Gn:BSU11420" /db_xref="EnsemblGenomes-Tr:CAB12999" /db_xref="GOA:P21656" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR002305" /db_xref="InterPro:IPR002306" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR024109" /db_xref="PDB:3PRH" /db_xref="SubtiList:BG10799" /db_xref="UniProtKB/Swiss-Prot:P21656" /translation="MKQTIFSGIQPSGSVTLGNYIGAMKQFVELQHDYNSYFCIVDQH AITVPQDRLELRKNIRNLAALYLAVGLDPEKATLFIQSEVPAHAQAGWMMQCVAYIGE LERMTQFKDKSKGNEAVVSGLLTYPPLMAADILLYGTDLVPVGEDQKQHLELTRNLAE RFNKKYNDIFTIPEVKIPKVGARIMSLNDPLKKMSKSDPNQKAYITLLDEPKQLEKKI KSAVTDSEGIVKFDKENKPGVSNLLTIYSILGNTTIEELEAKYEGKGYGEFKGDLAEV VVNALKPIQDRYYELIESEELDRILDEGAERANRTANKMLKKMENAMGLGRKRR*" /label="trpS CDS" gene complement(1167684..1168676) /gene="trpS" /locus_tag="BSU_11420" /old_locus_tag="BSU11420" /label="trpS gene" downshifts complement(1167705) /Source="Nicolas_upshifts" /id="D621" /incds=0 /nref=224 /ntot=255 /MaxReadThrough="1.77115" /MaxDrop="6.72647" /score="27.6275522" /energy="-11.6" /TU="U919" /idTUdmin="U919" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" misc_RNA complement(1168735..1168949) /gene="tboWA" /locus_tag="BSU_misc_RNA_13" /product="T-box riboswitch specific of tryptophan tRNA" /experiment="publication(s) with functional evidences, PMID:8045882, 9098041, 10706627, 10943892, 11842119, 12165569, 12547201, 1317842" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045882, 9098041, 10706627, 10943892, 11842119, 12165569, 12547201, 1317842; Product type n: RNA" /function="16.3: Control" /label="tboWA RNA" gene complement(1168735..1168949) /gene="tboWA" /locus_tag="BSU_misc_RNA_13" /label="tboWA gene" downshifts complement(1168783) /Source="Nicolas_upshifts" /id="D622" /incds=0 /nref=37 /ntot=127 /MaxReadThrough="6.8472" /MaxDrop="5.13001" /score="25.1445248" /energy="-19" /TU="U919" /idTUdmin="U919" /TUdmin="-1100" /isTUend="FALSE" /label="downshifts" misc_feature complement(1168968..1168987) /Source="Nicolas_upshift_promotors" /id="U919" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.509490509490509" /psig="0.99100899100899" /xcortree=602 /SigmaFactorBS="tatttatattattacaattttactggaaaaaagaatgttttt tcatgatgacaaTTGGTTATAATTGATTTATAatgaagcaatcaaaagaaaagcttgc t" /listShort="NA, trpS" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1168981) /Source="Nicolas_upshifts" /id="U919" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.509490509490509" /psig="0.99100899100899" /xcortree=602 /SigmaFactorBS="tatttatattattacaattttactggaaaaaagaatgttttt tcatgatgacaaTTGGTTATAATTGATTTATAatgaagcaatcaaaagaaaagcttgc t" /listShort="NA, trpS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1169236..1169243 /Source="Nicolas_upshift_promotors" /id="U920" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.828171828171828" /psig=1 /xcortree=491 /SigmaFactorBS="aactaacgaagtttaaatattttaaattgataaaataaTATT GCAAtaaattatttgtttCATTATAATGAACTTGTTCActctattgttacagcttttt t" /listShort="S406, oppA, S407, oppB, oppC, oppD, oppF" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1169257..1169419 /Source="Nicolas_S_feature" /locus_tag="new_1219686_1219848" /HighExp="S1, T3.0H, T3.30H, T2.30H, T4.0H, T5.0H, LoTm, T2.0H, M40t90, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S406" promotor_-10 1169258..1169277 /Source="Nicolas_upshift_promotors" /id="U920" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.828171828171828" /psig=1 /xcortree=491 /SigmaFactorBS="aactaacgaagtttaaatattttaaattgataaaataaTATT GCAAtaaattatttgtttCATTATAATGAACTTGTTCActctattgttacagcttttt t" /listShort="S406, oppA, S407, oppB, oppC, oppD, oppF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1169258 /Source="Nicolas_upshifts" /id="U920" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.828171828171828" /psig=1 /xcortree=491 /SigmaFactorBS="aactaacgaagtttaaatattttaaattgataaaataaTATT GCAAtaaattatttgtttCATTATAATGAACTTGTTCActctattgttacagcttttt t" /listShort="S406, oppA, S407, oppB, oppC, oppD, oppF" /GFF_Attribute="listLong" /label="upshifts" CDS 1169420..1171057 /gene="oppA" /locus_tag="BSU_11430" /old_locus_tag="BSU11430" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:1901616, 11083832, 11401703, 12823818, 15588833, 23133654, 26176322, 22720735, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1901616, 11083832, 11401703, 12823818, 15588833, 23133654, 26176322, 22720735, 25355936; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (binding lipoprotein)" /protein_id="NP_389025.1" /db_xref="EnsemblGenomes-Gn:BSU11430" /db_xref="EnsemblGenomes-Tr:CAB13000" /db_xref="GOA:P24141" /db_xref="InterPro:IPR000914" /db_xref="InterPro:IPR023765" /db_xref="InterPro:IPR030678" /db_xref="SubtiList:BG10771" /db_xref="UniProtKB/Swiss-Prot:P24141" /translation="MKKRWSIVTLMLIFTLVLSACGFGGSGSNGEGKKDSKGKTTLNI NIKTEPFSLHPGLANDSVSGGVIRQTFEGLTRINADGEPEEGMASKIETSKDGKTYTF TIRDGVKWSNGDPVTAQDFEYAWKWALDPNNESQYAYQLYYIKGAEAANTGKGSLDDV AVKAVNDKTLKVELNNPTPYFTELTAFYTYMPINKKIAEKNKKWNTNAGDDYVSNGPF KMTAWKHSGSITLEKNDQYWDKDKVKLKKIDMVMINNNNTELKKFQAGELDWAGMPLG QLPTESLPTLKKDGSLHVEPIAGVYWYKFNTEAKPLDNVNIRKALTYSLDRQSIVKNV TQGEQIPAMAAVPPTMKGFEDNKEGYFKDNDVKTAKEYLEKGLKEMGLSKASDLPKIK LSYNTDDAHAKIAQAVQEMWKKNLGVDVELDNSEWNVYIDKLHSQDYQIGRMGWLGDF NDPINFLELFRDKNGGNNDTGWENPEFKKLLNQSQTETDKTKRAELLKKAEGIFIDEM PVAPIYFYTDTWVQDENLKGVIMPGTGEVYFRNAYFK*" /label="oppA CDS" gene 1169420..1171057 /gene="oppA" /locus_tag="BSU_11430" /old_locus_tag="BSU11430" /label="oppA gene" downshifts 1170951 /Source="Nicolas_upshifts" /id="D623" /incds=1 /nref=8 /ntot=166 /MaxReadThrough="6.94127" /MaxDrop="3.3677" /score="-4.2761508" /energy="-15.6" /TU="U920" /idTUdmin="U916" /TUdmin=3322 /isTUend="FALSE" /label="downshifts" S_feature 1171058..1171164 /Source="Nicolas_S_feature" /locus_tag="new_1221487_1221593" /HighExp="S1, LoTm, T4.0H, BT, T3.30H, T3.0H, T5.0H, M0t90, T2.30H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S407" CDS 1171165..1172100 /gene="oppB" /locus_tag="BSU_11440" /old_locus_tag="BSU11440" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:1901616, 11401703, 15849754, 16850406, 17600541, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1901616, 11401703, 15849754, 16850406, 17600541, 25355936; Product type t : transporter" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (permease)" /protein_id="NP_389026.1" /db_xref="EnsemblGenomes-Gn:BSU11440" /db_xref="EnsemblGenomes-Tr:CAB13001" /db_xref="GOA:P24138" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG10772" /db_xref="UniProtKB/Swiss-Prot:P24138" /translation="MLKYIGRRLVYMIITLFVIVTVTFFLMQAAPGGPFSGEKKLPPE IEANLNAHYGLDKPLFVQYVSYLKSVAMWDFGPSFKYKGQSVNDLISSGFPVSFTLGA EAILLALALGVLFGVIAALYHNKWQDYTVAILTIFGISVPSFIMAAVLQYVFSMKLGL FPVAGWDSWAYTFLPSIALASMPMAFIARLSRSSMIEVLNSDYIRTAKAKGLSRPAVT VRHAIRNALLPVVTYMGPMAAQVLTGSFIIETIFGIPGLGAHFVNSITNRDYTVIMGV TVFFSVILLLCVLIVDVLYGIIDPRIKLSKAKKGA*" /label="oppB CDS" gene 1171165..1172100 /gene="oppB" /locus_tag="BSU_11440" /old_locus_tag="BSU11440" /label="oppB gene" promotor_-10 complement(1171208..1171227) /Source="Nicolas_upshift_promotors" /id="U921" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.508491508491508" /psig="0.97902097902098" /xcortree=1450 /SigmaFactorBS="gctttttctcacctgaaaatggcccgcccggtgctgCTTGCA TtaagaagaatgtcacAGTTACAATCACAAATAGTGtgataatcatatagactaagcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1171225) /Source="Nicolas_upshifts" /id="U921" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.508491508491508" /psig="0.97902097902098" /xcortree=1450 /SigmaFactorBS="gctttttctcacctgaaaatggcccgcccggtgctgCTTGCA TtaagaagaatgtcacAGTTACAATCACAAATAGTGtgataatcatatagactaagcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1171243..1171249) /Source="Nicolas_upshift_promotors" /id="U921" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.508491508491508" /psig="0.97902097902098" /xcortree=1450 /SigmaFactorBS="gctttttctcacctgaaaatggcccgcccggtgctgCTTGCA TtaagaagaatgtcacAGTTACAATCACAAATAGTGtgataatcatatagactaagcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1172104..1173021 /gene="oppC" /locus_tag="BSU_11450" /old_locus_tag="BSU11450" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:1901616, 11401703, 15849754, 16850406, 26782429" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1901616, 11401703, 15849754, 16850406, 26782429; Product type t : transporter" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (permease)" /protein_id="NP_389027.1" /db_xref="EnsemblGenomes-Gn:BSU11450" /db_xref="EnsemblGenomes-Tr:CAB13002" /db_xref="GOA:P24139" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR025966" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG10773" /db_xref="UniProtKB/Swiss-Prot:P24139" /translation="MQNIPKNMFEPAAANAGDAEKISKKSLSLWKDAMLRFRSNKLAM VGLIIIVLIILMAIFAPMFSRYDYSTTNLLNADKPPSKDHWFGTDDLGRDIFVRTWVG ARISIFIGVAAAVLDLLIGVIWGSISGFRGGRTDEIMMRIADILWAVPSLLMVILLMV VLPKGLFTIIIAMTITGWINMARIVRGQVLQLKNQEYVLASQTLGAKTSRLLFKHIVP NAMGSILVTMTLTVPTAIFTEAFLSYLGLGVPAPLASWGTMASDGLPALTYYPWRLFF PAGFICITMFGFNVVGDGLRDALDPKLRK*" /label="oppC CDS" gene 1172104..1173021 /gene="oppC" /locus_tag="BSU_11450" /old_locus_tag="BSU11450" /label="oppC gene" CDS 1173026..1174102 /gene="oppD" /locus_tag="BSU_11460" /old_locus_tag="BSU11460" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:1901616, 11401703, 19202088, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1901616, 11401703, 19202088, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (ATP-binding protein)" /protein_id="NP_389028.1" /db_xref="EnsemblGenomes-Gn:BSU11460" /db_xref="EnsemblGenomes-Tr:CAB13003" /db_xref="GOA:P24136" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR013563" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10774" /db_xref="UniProtKB/Swiss-Prot:P24136" /translation="MIRVTRLLEVKDLAISFKTYGGEVQAIRGVNFHLDKGETLAIVG ESGSGKSVTSQAIMKLIPMPPGYFKRGEILFEGKDLVPLSEKEMQNVRGKEIGMIFQD PMTSLNPTMKVGKQITEVLFKHEKISKEAAKKRAVELLELVGIPMPEKRVNQFPHEFS GGMRQRVVIAMALAANPKLLIADEPTTALDVTIQAQILELMKDLQKKIDTSIIFITHD LGVVANVADRVAVMYAGQIVETGTVDEIFYDPRHPYTWGLLASMPTLESSGEEELTAI PGTPPDLTNPPKGDAFALRSSYAMKIDFEQEPPMFKVSDTHYVKSWLLHPDAPKVEPP EAVKAKMRKLANTFEKPVLVREVE*" /label="oppD CDS" gene 1173026..1174102 /gene="oppD" /locus_tag="BSU_11460" /old_locus_tag="BSU11460" /label="oppD gene" CDS 1174104..1175021 /gene="oppF" /locus_tag="BSU_11470" /old_locus_tag="BSU11470" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:1901616, 7997159, 11401703, 23133654, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1901616, 7997159, 11401703, 23133654, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="oligopeptide ABC transporter (ATP-binding protein)" /protein_id="NP_389029.1" /db_xref="EnsemblGenomes-Gn:BSU11470" /db_xref="EnsemblGenomes-Tr:CAB13004" /db_xref="GOA:P24137" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR013563" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10775" /db_xref="UniProtKB/Swiss-Prot:P24137" /translation="MTEKLLEIKHLKQHFVTPRGTVKAVDDLSFDIYKGETLGLVGES GCGKSTTGRSIIRLYEATDGEVLFNGENVHGRKSRKKLLEFNRKMQMIFQDPYASLNP RMTVADIIAEGLDIHKLAKTKKERMQRVHELLETVGLNKEHANRYPHEFSGGQRQRIG IARALAVDPEFIIADEPISALDVSIQAQVVNLMKELQKEKGLTYLFIAHDLSMVKYIS DRIGVMYFGKLVELAPADELYENPLHPYTKSLLSAIPLPDPDYERNRVRQKYDPSVHQ LKDGETMEFREVKPGHFVMCTEAEFKAFS*" /label="oppF CDS" gene 1174104..1175021 /gene="oppF" /locus_tag="BSU_11470" /old_locus_tag="BSU11470" /label="oppF gene" downshifts 1174991 /Source="Nicolas_upshifts" /id="D624" /incds=0 /nref=21 /ntot=196 /MaxReadThrough="1.58906" /MaxDrop="5.17491" /score="28.2861081" /energy="-15.2" /TU="NA" /idTUdmin="U920" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" promotor_-35 1175071..1175074 /Source="Nicolas_upshift_promotors" /id="U922" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.651348651348651" /psig="0.97002997002997" /xcortree=3166 /SigmaFactorBS="caatccttcaagagatttctcttgaaggatttttttgcgtct tcATAGaaagtgagaatgatAACATTTACAATTAGAGGAAaaagcggaggcgaaatac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1175087 /Source="Nicolas_upshifts" /id="U922" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.651348651348651" /psig="0.97002997002997" /xcortree=3166 /SigmaFactorBS="caatccttcaagagatttctcttgaaggatttttttgcgtct tcATAGaaagtgagaatgatAACATTTACAATTAGAGGAAaaagcggaggcgaaatac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1175089..1175108 /Source="Nicolas_upshift_promotors" /id="U922" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.651348651348651" /psig="0.97002997002997" /xcortree=3166 /SigmaFactorBS="caatccttcaagagatttctcttgaaggatttttttgcgtct tcATAGaaagtgagaatgatAACATTTACAATTAGAGGAAaaagcggaggcgaaatac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1175128..1176345 /gene="yjbB" /locus_tag="BSU_11480" /old_locus_tag="BSU11480" /function="16.1: Circulate" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14563878, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative exporter" /protein_id="NP_389030.2" /db_xref="EnsemblGenomes-Gn:BSU11480" /db_xref="EnsemblGenomes-Tr:CAB13005" /db_xref="GOA:O31600" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13131" /db_xref="UniProtKB/Swiss-Prot:O31600" /translation="MQFLHNKNVFALLLSQSFQSLAGVLVTIVLMVRIYQMTDSVFLA GLILSFMSFASIAASFCVSPVLRILGFKKVLAGANLLRAVFIILMAYSVTHHGQAFFW ITLLFVFCFSFAGAFFQPARFALLPIIVPKKQYVKANGVISLSNQLFLTAGWGLGGLL TYAVPFELVVGAAICLFVLSGASISVLHVNEEEAAGTAETASVRSIWKDLMIIPIVRD ITVMDMLEALAGSVWSSAILLAFTAAVLHETEVWWGMFNASYFIGAIVGSVIAIRFSS FFERNMGYAIMFSSLVMSALTLLFSFSPVPFLCALACAAMGPFYQVRDICQETMLQEV IPEQKRIGIMAAKNAILTPWSGVTYSIMGLVADAAGAKIAFIAAAALYIMTFLIALAQ PRLVHYRRENRVQ*" /label="yjbB CDS" gene 1175128..1176345 /gene="yjbB" /locus_tag="BSU_11480" /old_locus_tag="BSU11480" /label="yjbB gene" promotor_-35 1176398..1176407 /Source="Nicolas_upshift_promotors" /id="U923" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=114 /SigmaFactorBS="cagctggctccgttttgctgaaaaaaaaaTGAAACCATGgcg gaagttcgcACGTCTTTATAGATGTaaggctgtttaaacaagaagaaatggggtatat c" /listShort="S408, yjbC, S409, spxA, S410" /listLong="S411, mecA" /label="promotor_-35" promotor_-10 1176420..1176435 /Source="Nicolas_upshift_promotors" /id="U923" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=114 /SigmaFactorBS="cagctggctccgttttgctgaaaaaaaaaTGAAACCATGgcg gaagttcgcACGTCTTTATAGATGTaaggctgtttaaacaagaagaaatggggtatat c" /listShort="S408, yjbC, S409, spxA, S410" /listLong="S411, mecA" /label="promotor_-10" S_feature 1176429..1176508 /Source="Nicolas_S_feature" /locus_tag="new_1226858_1226937" /HighExp="Etha, B60, M9-stat, T0.30H, Salt, T3.0H, T1.0H, T4.0H, T2.30H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S408" upshifts 1176429 /Source="Nicolas_upshifts" /id="U923" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=114 /SigmaFactorBS="cagctggctccgttttgctgaaaaaaaaaTGAAACCATGgcg gaagttcgcACGTCTTTATAGATGTaaggctgtttaaacaagaagaaatggggtatat c" /listShort="S408, yjbC, S409, spxA, S410" /listLong="S411, mecA" /label="upshifts" CDS 1176509..1177087 /gene="yjbC" /locus_tag="BSU_11490" /old_locus_tag="BSU11490" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17158660, 17158663, 21815947; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative thiol oxidation management factor; putative acetyltransferase" /protein_id="NP_389031.2" /db_xref="EnsemblGenomes-Gn:BSU11490" /db_xref="EnsemblGenomes-Tr:CAB13006" /db_xref="GOA:O31601" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13132" /db_xref="UniProtKB/Swiss-Prot:O31601" /translation="MNWYEKLSEYFPIEEMKSKAHMEALLKERSDIYHKDEGKHHILM FAEFDSFIFVDYLYVSKDARGQGLGGKLIAKLKKKNKPILLEVEPVDEDDTDTEKRLR FYQREHFKHAQSIGYRRRSLATNEVNKMEILYWSPKTESEEEILEAMKQTYENIHTYK DEKWYGESYEKTDEVLEIIDEEKQKNIFDQLS*" /label="yjbC CDS" gene 1176509..1177087 /gene="yjbC" /locus_tag="BSU_11490" /old_locus_tag="BSU11490" /label="yjbC gene" S_feature 1177088..1177202 /Source="Nicolas_S_feature" /locus_tag="new_1227517_1227631" /HighExp="B60, Etha, Salt, T0.30H, M9-stat, LoTm, Gly, T1.0H, B36, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S409" promotor_-10 complement(1177139..1177158) /Source="Nicolas_upshift_promotors" /id="U924" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.507492507492508" /psig="0.622377622377622" /xcortree=51 /SigmaFactorBS="aaaaaggaatctttacaggtattaTACTATAAaaaagtaagt gtgAACAGTATCCTAAGAAAAAAatgtgtcaatccagcaaatttttaatgttcatgat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1177143) /Source="Nicolas_upshifts" /id="U924" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.507492507492508" /psig="0.622377622377622" /xcortree=51 /SigmaFactorBS="aaaaaggaatctttacaggtattaTACTATAAaaaagtaagt gtgAACAGTATCCTAAGAAAAAAatgtgtcaatccagcaaatttttaatgttcatgat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1177172..1177179) /Source="Nicolas_upshift_promotors" /id="U924" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.507492507492508" /psig="0.622377622377622" /xcortree=51 /SigmaFactorBS="aaaaaggaatctttacaggtattaTACTATAAaaaagtaagt gtgAACAGTATCCTAAGAAAAAAatgtgtcaatccagcaaatttttaatgttcatgat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 1177205..1177218 /Source="Nicolas_upshift_promotors" /id="U925" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.815184815184815" /psig="0.973026973026973" /xcortree=1536 /SigmaFactorBS="cttaggatactgttcacacttacttttttatagtataatacc tgtaaagattccttttttAGAGTAATTTCAATttaagaataaaatagatgttcatcct a" /listShort="spxA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1177205 /Source="Nicolas_upshifts" /id="U925" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.815184815184815" /psig="0.973026973026973" /xcortree=1536 /SigmaFactorBS="cttaggatactgttcacacttacttttttatagtataatacc tgtaaagattccttttttAGAGTAATTTCAATttaagaataaaatagatgttcatcct a" /listShort="spxA" /GFF_Attribute="listLong" /label="upshifts" CDS 1177268..1177663 /gene="spxA" /locus_tag="BSU_11500" /old_locus_tag="BSU11500" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12642660, 14597697, 15659166, 16249335, 16740936, 18662407, 22307755, 23894131, 28484046, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12642660, 14597697, 15659166, 16249335, 16740936, 18662407, 22307755, 23894131, 28484046, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="redox-sensitive regulator" /protein_id="NP_389032.1" /db_xref="EnsemblGenomes-Gn:BSU11500" /db_xref="EnsemblGenomes-Tr:CAB13007" /db_xref="GOA:O31602" /db_xref="InterPro:IPR006504" /db_xref="InterPro:IPR006660" /db_xref="InterPro:IPR023731" /db_xref="InterPro:IPR036249" /db_xref="PDB:1Z3E" /db_xref="PDB:3GFK" /db_xref="PDB:3IHQ" /db_xref="SubtiList:BG13133" /db_xref="UniProtKB/Swiss-Prot:O31602" /translation="MVTLYTSPSCTSCRKARAWLEEHEIPFVERNIFSEPLSIDEIKQ ILRMTEDGTDEIISTRSKVFQKLNVNVESMPLQDLYRLINEHPGLLRRPIIIDEKRLQ VGYNEDEIRRFLPRKVRSFQLREAQRLAN*" /label="spxA CDS" gene 1177268..1177663 /gene="spxA" /locus_tag="BSU_11500" /old_locus_tag="BSU11500" /label="spxA gene" promotor_no_box complement(1177499..1177599) /Source="Nicolas_upshift_promotors" /id="U926" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96103896103896" /psig="0.000999000999001" /xcortree=57 /SigmaFactorBS="ctgatttcgtcttcgttatatccgacctgcaaacgtttttcg tcaatgatgatcggacggcgaagcaaacctggatgctcgttgatcaagcggtacaaat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1177539) /Source="Nicolas_upshifts" /id="U926" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96103896103896" /psig="0.000999000999001" /xcortree=57 /SigmaFactorBS="ctgatttcgtcttcgttatatccgacctgcaaacgtttttcg tcaatgatgatcggacggcgaagcaaacctggatgctcgttgatcaagcggtacaaat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1177661 /Source="Nicolas_upshifts" /id="D625" /incds=0 /nref=263 /ntot=269 /MaxReadThrough="4.34531" /MaxDrop="8.0579" /score="7.42972561" /energy="-8.8" /TU="U923" /idTUdmin="U925" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 1177706..1178495 /Source="Nicolas_S_feature" /locus_tag="new_1228135_1228924" /HighExp="B60, B36, Etha, M9-stat, Salt, H2O2, Paraq, Cold, G180, G135" /AntisenseName="yjbE" /AntisenseCor="-0.18634010398760401" /AntisenseRegPval="-2.7" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S410" CDS complement(1177706..1178362) /gene="yjbE" /locus_tag="BSU_11510" /old_locus_tag="BSU11510" /function="16.8: Protect" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein of unknown function" /protein_id="NP_389033.1" /db_xref="EnsemblGenomes-Gn:BSU11510" /db_xref="EnsemblGenomes-Tr:CAB13008" /db_xref="GOA:O31603" /db_xref="InterPro:IPR005496" /db_xref="InterPro:IPR022301" /db_xref="SubtiList:BG13134" /db_xref="UniProtKB/Swiss-Prot:O31603" /translation="MEHDYLISLLVIVGIDLILGGDNAVVIAMASRHLPDKQRQQAII LGTFIAVAMRIGLTSAAVYLLNIPFLQCAGGIFLLYLGYQLLIEKKDTKHIKSSTSLW RAIRTIVLADLFMSLDNVIAVAGASHGEFSLVVIGLCVSVPVIIWGSKLIHIALEKIP LLIYAGSGLLAYTGGEMIVRDKKLSLFMAQHGTVETLLPILTVAFVILASIYYQQVEK *" /label="yjbE CDS" gene complement(1177706..1178362) /gene="yjbE" /locus_tag="BSU_11510" /old_locus_tag="BSU11510" /label="yjbE gene" promotor_-10 complement(1178392..1178410) /Source="Nicolas_upshift_promotors" /id="U927" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=987 /SigmaFactorBS="cacctttgcctaaaaaacggcagatcaggcggctgatATCAT AaaatatgacctgtcTCATATAGTAGTAGTACAAgcgaaggactgaaagcgaggtgcc g" /listShort="yjbE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1178407) /Source="Nicolas_upshifts" /id="U927" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=987 /SigmaFactorBS="cacctttgcctaaaaaacggcagatcaggcggctgatATCAT AaaatatgacctgtcTCATATAGTAGTAGTACAAgcgaaggactgaaagcgaggtgcc g" /listShort="yjbE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1178425..1178430) /Source="Nicolas_upshift_promotors" /id="U927" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=987 /SigmaFactorBS="cacctttgcctaaaaaacggcagatcaggcggctgatATCAT AaaatatgacctgtcTCATATAGTAGTAGTACAAgcgaaggactgaaagcgaggtgcc g" /listShort="yjbE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1178468..1178475 /Source="Nicolas_upshift_promotors" /id="U928" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.845154845154845" /psig="0.998001998001998" /xcortree=622 /SigmaFactorBS="cgcctgatctgccgttttttaggcaaaggtgCATTTTTAttt cttttgtgacTGTTTTATCATAAAATAGAAatacaaaggaattcacactggccttggt t" /listShort="S411, mecA, S412, S413, coiA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1178489..1178508 /Source="Nicolas_upshift_promotors" /id="U928" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.845154845154845" /psig="0.998001998001998" /xcortree=622 /SigmaFactorBS="cgcctgatctgccgttttttaggcaaaggtgCATTTTTAttt cttttgtgacTGTTTTATCATAAAATAGAAatacaaaggaattcacactggccttggt t" /listShort="S411, mecA, S412, S413, coiA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1178497..1178638 /Source="Nicolas_S_feature" /locus_tag="new_1228926_1229067" /HighExp="B60, Diami, Etha, dia5, LPhT, M9-stat, T5.0H, T3.0H, dia15, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="SigWXY" /TUlongPSig=1 /label="S411" upshifts 1178497 /Source="Nicolas_upshifts" /id="U928" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.845154845154845" /psig="0.998001998001998" /xcortree=622 /SigmaFactorBS="cgcctgatctgccgttttttaggcaaaggtgCATTTTTAttt cttttgtgacTGTTTTATCATAAAATAGAAatacaaaggaattcacactggccttggt t" /listShort="S411, mecA, S412, S413, coiA" /GFF_Attribute="listLong" /label="upshifts" CDS 1178532..1178672 /locus_tag="BSU_11515" /old_locus_tag="BSU11515" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_009513949.1" /translation="MVKVKMWTEWVKCSKVQLIGSLDVPSTSYIEGKVGKWKLKELTS IQ*" /label="conserved hypothetical protein CDS" gene 1178532..1178672 /locus_tag="BSU_11515" /old_locus_tag="BSU11515" /label="gene" CDS 1178639..1179295 /gene="mecA" /locus_tag="BSU_11520" /old_locus_tag="BSU11520" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10361283, 10447896, 16525504, 19801546, 21435029, 23595989" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10361283, 10447896, 16525504, 19801546, 21435029, 23595989; Product type f : factor" /codon_start=1 /transl_table=11 /product="adaptor protein controlling oligomerization of the AAA+ protein ClpC" /protein_id="NP_389034.1" /db_xref="EnsemblGenomes-Gn:BSU11520" /db_xref="EnsemblGenomes-Tr:CAB13009" /db_xref="GOA:P37958" /db_xref="InterPro:IPR008681" /db_xref="PDB:2Y1R" /db_xref="PDB:3J3R" /db_xref="PDB:3J3S" /db_xref="PDB:3J3T" /db_xref="PDB:3J3U" /db_xref="PDB:3JTP" /db_xref="PDB:3PXG" /db_xref="PDB:3PXI" /db_xref="SubtiList:BG10680" /db_xref="UniProtKB/Swiss-Prot:P37958" /translation="MEIERINEHTVKFYMSYGDIEDRGFDREEIWYNRERSEELFWEV MDEVHEEEEFAVEGPLWIQVQALDKGLEIIVTKAQLSKDGQKLELPIPEDKKQEPASE DLDALLDDFQKEEQAVNQEEKEQKLQFVLRFGDFEDVISLSKLNVNGSKTTLYSFENR YYLYVDFCNMTDEEVENQLSILLEYATESSISIHRLEEYGKLIISEHALETIKKHFAS *" /label="mecA CDS" gene 1178639..1179295 /gene="mecA" /locus_tag="BSU_11520" /old_locus_tag="BSU11520" /label="mecA gene" downshifts 1179285 /Source="Nicolas_upshifts" /id="D626" /incds=0 /nref=120 /ntot=308 /MaxReadThrough="5.41786" /MaxDrop="7.67172" /score="32.2431225" /energy="-11.8" /TU="U928" /idTUdmin="U928" /TUdmin="-774" /isTUend="FALSE" /label="downshifts" CDS complement(1179290..1179412) /locus_tag="BSU_11525" /old_locus_tag="BSU11525" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_009513950.1" /translation="MINSCSLYFLLVYMFLIFHISKMAFSCIKKTDFRKEIGLL*" /label="conserved hypothetical protein CDS" gene complement(1179290..1179412) /locus_tag="BSU_11525" /old_locus_tag="BSU11525" /label="gene" S_feature 1179330..1179419 /Source="Nicolas_S_feature" /locus_tag="new_1229759_1229848" /HighExp="Etha, M9-stat, B60, dia15, T0.30H, Diami, C30, H2O2, dia5, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S412" promotor_-35 1179398..1179406 /Source="Nicolas_upshift_promotors" /id="U929" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=2965 /SigmaFactorBS="aaatcaaaaacatatagacaagcagaaaatacagcgaACAGG AGTTgatcatctttTCCAGAAAGTATACTTCATctggaaaggagagatgacaattgtt t" /listShort="S413, coiA, pepF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1179417..1179435 /Source="Nicolas_upshift_promotors" /id="U929" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=2965 /SigmaFactorBS="aaatcaaaaacatatagacaagcagaaaatacagcgaACAGG AGTTgatcatctttTCCAGAAAGTATACTTCATctggaaaggagagatgacaattgtt t" /listShort="S413, coiA, pepF" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1179421..1179485 /Source="Nicolas_S_feature" /locus_tag="new_1229850_1229914" /HighExp="Etha, G/S, GM 150, T-4.40H, S2, T-2.40H, Pyr, C90, M9-tran, T-3.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH, SigA" /TUshortPSig="0.876, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S413" upshifts 1179421 /Source="Nicolas_upshifts" /id="U929" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=2965 /SigmaFactorBS="aaatcaaaaacatatagacaagcagaaaatacagcgaACAGG AGTTgatcatctttTCCAGAAAGTATACTTCATctggaaaggagagatgacaattgtt t" /listShort="S413, coiA, pepF" /GFF_Attribute="listLong" /label="upshifts" CDS 1179486..1180607 /gene="coiA" /locus_tag="BSU_11530" /old_locus_tag="BSU11530" /function="16.1: Circulate" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10438773, 17630974, 23046409, 26880300" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10438773, 17630974, 23046409, 26880300; Product type s: structure" /codon_start=1 /transl_table=11 /product="protein involved in establishment of DNA transport in competence" /protein_id="NP_389035.1" /db_xref="EnsemblGenomes-Gn:BSU11530" /db_xref="EnsemblGenomes-Tr:CAB13010" /db_xref="GOA:O31604" /db_xref="InterPro:IPR010330" /db_xref="InterPro:IPR021176" /db_xref="SubtiList:BG13135" /db_xref="UniProtKB/Swiss-Prot:O31604" /translation="MFHLLGAQQNQKLKRRRFFCPVCGGELAVKLGLQKAPHFAHKQN KSCAIDIEPESAYHLEGKRQLYVWLKTQRASPILEPYIRTINQRPDVMARIKEHMLAV EYQCATIAPDVFQKRTEGFKQEGIIPQWIMGYSRLKRTASSFYQLSTFHWQFINASPY RELICYCPERRSFLRLSHIIPFYTNHSYSSVQTIPIHRAGAGDLFFTEPKPSIQYSGW TKAIHRFRHKPHRFNSKETNRLRLLFYEKRQTPFSFLPTEVFVPVRKGAVFKSPVFVW QGFLYLFMTDLGGKRAPIRFSAVLQQCKLHIHNKNIALRSECSEECLSEAVKQYIDFL CKKGFLRETQKEVYVLNQPAGGIHSMQDLIERDRSCFIE*" /label="coiA CDS" gene 1179486..1180607 /gene="coiA" /locus_tag="BSU_11530" /old_locus_tag="BSU11530" /label="coiA gene" promotor_-35 1180261..1180267 /Source="Nicolas_upshift_promotors" /id="U930" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=156 /SigmaFactorBS="atgagaaacgacagacgcctttttcttttctgccgactgaag TGTTTGTtcctgttagaaaagGGGCAGTTTTTAAGAGTCCggtttttgtgtggcaggg g" /listShort="pepF" /listLong="S414, S415" /label="promotor_-35" upshifts 1180279 /Source="Nicolas_upshifts" /id="U930" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=156 /SigmaFactorBS="atgagaaacgacagacgcctttttcttttctgccgactgaag TGTTTGTtcctgttagaaaagGGGCAGTTTTTAAGAGTCCggtttttgtgtggcaggg g" /listShort="pepF" /listLong="S414, S415" /label="upshifts" promotor_-10 1180282..1180300 /Source="Nicolas_upshift_promotors" /id="U930" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=156 /SigmaFactorBS="atgagaaacgacagacgcctttttcttttctgccgactgaag TGTTTGTtcctgttagaaaagGGGCAGTTTTTAAGAGTCCggtttttgtgtggcaggg g" /listShort="pepF" /listLong="S414, S415" /label="promotor_-10" promotor_-35 1180493..1180501 /Source="Nicolas_upshift_promotors" /id="U931" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=546 /SigmaFactorBS="agcggttaaacagtatattgattttttgtgcaaGAAGGGATT tttaagggagaCTCAGAAAGAAGTATATGTgctgaatcagcctgcaggaggcatacac t" /listShort="pepF" /listLong="S414, S415" /label="promotor_-35" promotor_-10 1180513..1180531 /Source="Nicolas_upshift_promotors" /id="U931" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=546 /SigmaFactorBS="agcggttaaacagtatattgattttttgtgcaaGAAGGGATT tttaagggagaCTCAGAAAGAAGTATATGTgctgaatcagcctgcaggaggcatacac t" /listShort="pepF" /listLong="S414, S415" /label="promotor_-10" upshifts 1180520 /Source="Nicolas_upshifts" /id="U931" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=546 /SigmaFactorBS="agcggttaaacagtatattgattttttgtgcaaGAAGGGATT tttaagggagaCTCAGAAAGAAGTATATGTgctgaatcagcctgcaggaggcatacac t" /listShort="pepF" /listLong="S414, S415" /label="upshifts" promotor_-35 1180601..1180607 /Source="Nicolas_upshift_promotors" /id="U932" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=911 /SigmaFactorBS="tctcatagaaagagaccgcagctgttttatAGAATGAgtttg tcttatttgGCTCACCCTAAGacaaaggtggtgggcaggctgtgaaaggcacaaaagg a" /listShort="pepF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1180622..1180633 /Source="Nicolas_upshift_promotors" /id="U932" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=911 /SigmaFactorBS="tctcatagaaagagaccgcagctgttttatAGAATGAgtttg tcttatttgGCTCACCCTAAGacaaaggtggtgggcaggctgtgaaaggcacaaaagg a" /listShort="pepF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1180631 /Source="Nicolas_upshifts" /id="U932" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=911 /SigmaFactorBS="tctcatagaaagagaccgcagctgttttatAGAATGAgtttg tcttatttgGCTCACCCTAAGacaaaggtggtgggcaggctgtgaaaggcacaaaagg a" /listShort="pepF" /GFF_Attribute="listLong" /label="upshifts" CDS 1180654..1182666 /gene="pepF" /locus_tag="BSU_11540" /old_locus_tag="BSU11540" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11741842" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11741842; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="oligoendopeptidase F" /protein_id="NP_389036.2" /db_xref="EnsemblGenomes-Gn:BSU11540" /db_xref="EnsemblGenomes-Tr:CAB13011" /db_xref="GOA:O31605" /db_xref="InterPro:IPR001567" /db_xref="InterPro:IPR004438" /db_xref="InterPro:IPR013647" /db_xref="SubtiList:BG13136" /db_xref="UniProtKB/Swiss-Prot:O31605" /translation="MKGTKGKVFRVFTAFLAFVLFITAYDLTKGSEKPEDIHNTSLLR NSCFFNWLESKKTRGITMAEEKKANQLPDRSEVKAEDTWRLEDIFPSDEAWNKEFQAV KELIPNLSKYKGKLADSADHLYEALTYQDKVMERLGRLYTYAHMRSDQDTGNSFYQGL NDKAGNLYTQAASATAYLVPEILSIEEDKLQQFILEKEELKLYSHAIEEITKERPHVL SEKEEALLAEASEVLGSSSNTFSVLNNADITFPSIKDEDGNEKQITHGNFINFLESEN REVRKNAFDAVYKTYGQYKNTMATTLSGTVKKDNFYARVKKYKSAREAALSNNSIPEE VYDNLVKTINKHLPLLHRYIALRKKVLELDEVHIYDLYTPLVKDAGMKVTYEEAKDYM LKGLAPLGEEYASILKEGLENRWVDVYENKGKRNGAYSSGAYGTNPYILMNWHNNVNN LFTLVHEFGHSVHSYYTRKHQPYPYGNYSIFVAEVASTTNEALLGEYLLNNLEDEKQR LYILNHMLEGFRGTVFRQTMFAEFEHLIHTKAQEGEPLTPELLTNVYYDLNKKYFGDG MVIDKEIGLEWSRIPHFYYNYYVYQYATGYSAAQALSSQILKEGKPAVDRYIDFLKAG SSQYPIDVLKKAGVDMTSPEPIEAACKMFEEKLDEMEELLMKVKQS*" /label="pepF CDS" gene 1180654..1182666 /gene="pepF" /locus_tag="BSU_11540" /old_locus_tag="BSU11540" /label="pepF gene" promotor_-35 1180729..1180736 /Source="Nicolas_upshift_promotors" /id="U933" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.802197802197802" /psig="0.926073926073926" /xcortree=3181 /SigmaFactorBS="cattcgttctcttcattactgcatatGATTTGACaaaaggca gtgaaaAACCGGAAGATATTCACAACacaagtttattgagaaacagctgttttttcaa t" /listShort="S414" /listLong="S415" /label="promotor_-35" promotor_-10 1180751..1180770 /Source="Nicolas_upshift_promotors" /id="U933" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.802197802197802" /psig="0.926073926073926" /xcortree=3181 /SigmaFactorBS="cattcgttctcttcattactgcatatGATTTGACaaaaggca gtgaaaAACCGGAAGATATTCACAACacaagtttattgagaaacagctgttttttcaa t" /listShort="S414" /listLong="S415" /label="promotor_-10" upshifts 1180763 /Source="Nicolas_upshifts" /id="U933" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.802197802197802" /psig="0.926073926073926" /xcortree=3181 /SigmaFactorBS="cattcgttctcttcattactgcatatGATTTGACaaaaggca gtgaaaAACCGGAAGATATTCACAACacaagtttattgagaaacagctgttttttcaa t" /listShort="S414" /listLong="S415" /label="upshifts" downshifts 1182613 /Source="Nicolas_upshifts" /id="D627" /incds=0 /nref=98 /ntot=339 /MaxReadThrough="4.70576" /MaxDrop="5.74441" /score="19.0969124" /energy="-15.2" /TU="U933" /idTUdmin="U931" /TUdmin=2 /isTUend="TRUE" /label="downshifts" S_feature 1182667..1182968 /Source="Nicolas_S_feature" /locus_tag="new_1233096_1233397" /HighExp="Etha, dia15, Diami, B60, M9-stat, S8, M0t90, dia5, B36, T0.30H" /AntisenseName="yizD" /AntisenseCor="-1.29003203536192E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.926" /TUlongSig="SigH, SigB" /TUlongPSig="0.999, 0.999" /label="S414" CDS complement(1182704..1182871) /gene="yizD" /locus_tag="BSU_11549" /old_locus_tag="BSU11549" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097703.1" /db_xref="EnsemblGenomes-Gn:BSU11549" /db_xref="EnsemblGenomes-Tr:CAX52593" /db_xref="GOA:C0H3Y6" /db_xref="UniProtKB/Swiss-Prot:C0H3Y6" /translation="MMSTLISIVCIAVFFCLNILGMMHMLPLYITSPLLFLSILFTLY RLNHRKTFKGF*" /label="yizD CDS" gene complement(1182704..1182871) /gene="yizD" /locus_tag="BSU_11549" /old_locus_tag="BSU11549" /label="yizD gene" downshifts complement(1182717) /Source="Nicolas_upshifts" /id="D628" /incds=0 /nref=8 /ntot=61 /MaxReadThrough="1.527" /MaxDrop="5.54041" /score="-4.56163992" /energy="-15.2" /TU="NA" /idTUdmin="U934" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1182891..1182909) /Source="Nicolas_upshift_promotors" /id="U934" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1166 /SigmaFactorBS="acaacctctatgcttaatgttcatatttttgtcacaaAACAT AacgaagtgcattcacTCATATCCTTATAAGGAAAaaggacgaggaggaccgccatga t" /listShort="yizD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1182907) /Source="Nicolas_upshifts" /id="U934" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1166 /SigmaFactorBS="acaacctctatgcttaatgttcatatttttgtcacaaAACAT AacgaagtgcattcacTCATATCCTTATAAGGAAAaaggacgaggaggaccgccatga t" /listShort="yizD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1182925..1182930) /Source="Nicolas_upshift_promotors" /id="U934" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1166 /SigmaFactorBS="acaacctctatgcttaatgttcatatttttgtcacaaAACAT AacgaagtgcattcacTCATATCCTTATAAGGAAAaaggacgaggaggaccgccatga t" /listShort="yizD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1182961..1182968 /Source="Nicolas_upshift_promotors" /id="U935" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.583416583416583" /psig="0.883116883116883" /xcortree=90 /SigmaFactorBS="gtgaatgcacttcgttatgttttgtgacaaaaatatgaacat taagcatagAGGTTGTCaaaagtcgacatctTTTGTTATCATAAGGATGTGaaattga t" /listShort="S415" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1182970..1183095 /Source="Nicolas_S_feature" /locus_tag="new_1233399_1233524" /HighExp="B36, T-1.10H, nit, T-0.40H, M9-tran, LoTm, Pyr, Etha, Salt, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.883" /TUlongSig="SigA, SigH, SigB" /TUlongPSig="0.926, 0.999, 0.999" /label="S415" upshifts 1182970 /Source="Nicolas_upshifts" /id="U935" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.583416583416583" /psig="0.883116883116883" /xcortree=90 /SigmaFactorBS="gtgaatgcacttcgttatgttttgtgacaaaaatatgaacat taagcatagAGGTTGTCaaaagtcgacatctTTTGTTATCATAAGGATGTGaaattga t" /listShort="S415" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 1182976..1183114 /gene="roxS" /locus_tag="BSU_misc_RNA_67" /product="small regulatory RNA (NO regulated)" /experiment="publication(s) with functional evidences, PMID:19682248, 19786493, 20511587, 20525796, 25643072, 28436820" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19682248, 19786493, 20511587, 20525796, 25643072, 28436820; Product type n : RNA" /label="roxS RNA" gene 1182976..1183114 /gene="roxS" /locus_tag="BSU_misc_RNA_67" /label="roxS gene" promotor_-10 1182983..1183002 /Source="Nicolas_upshift_promotors" /id="U935" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.583416583416583" /psig="0.883116883116883" /xcortree=90 /SigmaFactorBS="gtgaatgcacttcgttatgttttgtgacaaaaatatgaacat taagcatagAGGTTGTCaaaagtcgacatctTTTGTTATCATAAGGATGTGaaattga t" /listShort="S415" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 1183052 /Source="Nicolas_upshifts" /id="D629" /incds=0 /nref=96 /ntot=135 /MaxReadThrough="3.50613" /MaxDrop="9.07209" /score="5.30186633" /energy="-11.6" /TU="U935" /idTUdmin="U933" /TUdmin=89 /isTUend="FALSE" /label="downshifts" CDS complement(1183185..1184084) /gene="spxH" /locus_tag="BSU_11550" /old_locus_tag="BSU11550" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:17293416, 17908206, 21378193, 22194450, 24942655, 25353645, 27191337, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17293416, 17908206, 21378193, 22194450, 24942655, 25353645, 27191337, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="thiol management effector of SpxA degradation" /protein_id="NP_389037.2" /db_xref="EnsemblGenomes-Gn:BSU11550" /db_xref="EnsemblGenomes-Tr:CAB13012" /db_xref="GOA:O31606" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG13137" /db_xref="UniProtKB/Swiss-Prot:O31606" /translation="MTNYQHELYFAHCHGHPKKPLEIYMFVDPLCPECWSLEPVIKKL KIRYGRFFTLRIIASASLTALNKKRKKHLLAEAWEKIASRSGMSCDGNVWFEQDQPLS SPYMAALAFKAAELQGRKAGMQFLRNMQESLFVSKKNITDENVLLEIAENTSLDLEEF KKDLHSQSAVKALQCDMKIAAEMDVSVNPTLTFFNTQHEDEGLKVPGSYSYDVYEEIL FEMLGDEPKPSETPPLECFIEYFRFVASKEIALVYDLSLEEVEKEMKKLAFAKKVAKV EAKHGMFWKSLSTYSDEYQSCEK*" /label="spxH CDS" gene complement(1183185..1184084) /gene="spxH" /locus_tag="BSU_11550" /old_locus_tag="BSU11550" /label="spxH gene" downshifts complement(1183216) /Source="Nicolas_upshifts" /id="D630" /incds=0 /nref=185 /ntot=251 /MaxReadThrough="3.70729" /MaxDrop="5.65601" /score="17.9327625" /energy="-13.3" /TU="U937" /idTUdmin="U937" /TUdmin="-89" /isTUend="FALSE" /label="downshifts" promotor_-35 1183420..1183425 /Source="Nicolas_upshift_promotors" /id="U936" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1111 /SigmaFactorBS="ataaaacattctaaaggcggtgtttccgacggcttcggctcg tcgccaAGCATCtcaaataaaatttctTCATATACATCATATGAGTagctgccaggaa c" /listShort="S416" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1183432 /Source="Nicolas_upshifts" /id="U936" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1111 /SigmaFactorBS="ataaaacattctaaaggcggtgtttccgacggcttcggctcg tcgccaAGCATCtcaaataaaatttctTCATATACATCATATGAGTagctgccaggaa c" /listShort="S416" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1183441..1183459 /Source="Nicolas_upshift_promotors" /id="U936" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1111 /SigmaFactorBS="ataaaacattctaaaggcggtgtttccgacggcttcggctcg tcgccaAGCATCtcaaataaaatttctTCATATACATCATATGAGTagctgccaggaa c" /listShort="S416" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1183448..1185349 /Source="Nicolas_S_feature" /locus_tag="new_1233877_1235778" /HighExp="S6, S4, S5, S8, S3, S7, BT, B36, C30, T5.0H" /AntisenseName="yjbH" /AntisenseCor="-0.61019541931037402" /AntisenseRegPval="-28.1" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S416" CDS complement(1184081..1184479) /gene="yjbI" /locus_tag="BSU_11560" /old_locus_tag="BSU11560" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15866723, 17293416; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative thiol management oxidoreductase component" /protein_id="NP_389038.1" /db_xref="EnsemblGenomes-Gn:BSU11560" /db_xref="EnsemblGenomes-Tr:CAB13013" /db_xref="GOA:O31607" /db_xref="InterPro:IPR001486" /db_xref="InterPro:IPR009050" /db_xref="InterPro:IPR019795" /db_xref="PDB:1UX8" /db_xref="SubtiList:BG13138" /db_xref="UniProtKB/Swiss-Prot:O31607" /translation="MGQSFNAPYEAIGEELLSQLVDTFYERVASHPLLKPIFPSDLTE TARKQKQFLTQYLGGPPLYTEEHGHPMLRARHLPFPITNERADAWLSCMKDAMDHVGL EGEIREFLFGRLELTARHMVNQTEAEDRSS*" /label="yjbI CDS" gene complement(1184081..1184479) /gene="yjbI" /locus_tag="BSU_11560" /old_locus_tag="BSU11560" /label="yjbI gene" S_feature complement(1184480..1184659) /Source="Nicolas_S_feature" /locus_tag="new_1234909_1235088_c" /HighExp="Diami, dia5, dia15, Etha, H2O2, C90, LoTm, Heat, Salt, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigD, SigA" /TUlongPSig="1, 0.999" /label="S417" promotor_-10 complement(1184651..1184670) /Source="Nicolas_upshift_promotors" /id="U937" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=1912 /SigmaFactorBS="tccctctggtttttttgcgaagtgaaatctTACGCATTcctg atttttaTGTGATATGATATGAAATACaaaccccggctgtcagccgaaatgagtcatc a" /listShort="S417, yjbI, yjbH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1184659) /Source="Nicolas_upshifts" /id="U937" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=1912 /SigmaFactorBS="tccctctggtttttttgcgaagtgaaatctTACGCATTcctg atttttaTGTGATATGATATGAAATACaaaccccggctgtcagccgaaatgagtcatc a" /listShort="S417, yjbI, yjbH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1184682..1184689) /Source="Nicolas_upshift_promotors" /id="U937" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=1912 /SigmaFactorBS="tccctctggtttttttgcgaagtgaaatctTACGCATTcctg atttttaTGTGATATGATATGAAATACaaaccccggctgtcagccgaaatgagtcatc a" /listShort="S417, yjbI, yjbH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1184734..1185279) /gene="cwlQ" /locus_tag="BSU_11570" /old_locus_tag="BSU11570" /EC_number="3.2.1.-" /EC_number="3.2.1.17" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:20609359" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20609359; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional muramidase and murein lytic transglycosylase" /protein_id="NP_389039.1" /db_xref="EnsemblGenomes-Gn:BSU11570" /db_xref="EnsemblGenomes-Tr:CAB13014" /db_xref="GOA:O31608" /db_xref="InterPro:IPR000189" /db_xref="InterPro:IPR008258" /db_xref="InterPro:IPR023346" /db_xref="SubtiList:BG13139" /db_xref="UniProtKB/Swiss-Prot:O31608" /translation="MLNSANTTAPSLLSAYGLNSYTSSNSGSVTKAAESTETAVADSA SNKHEANQIRSGDFSIDSAIKKAADKYGVDEKLIRAVIKQESGFNAKAVSGAGAMGLM QLMPSTASSLGVSNPLDPQQNVEGGTKYLKQMLDKYDGNVSMALAAYNAGPGNVDRYG GIPPFQETQNYVKKITSVYYA*" /label="cwlQ CDS" gene complement(1184734..1185279) /gene="cwlQ" /locus_tag="BSU_11570" /old_locus_tag="BSU11570" /label="cwlQ gene" downshifts complement(1184758) /Source="Nicolas_upshifts" /id="D631" /incds=0 /nref=101 /ntot=222 /MaxReadThrough="4.1014" /MaxDrop="5.00847" /score="6.97790581" /energy="-9.1" /TU="U938,U939" /idTUdmin="U938" /TUdmin="-90" /isTUend="FALSE" /label="downshifts" S_feature complement(1185280..1185482) /Source="Nicolas_S_feature" /locus_tag="new_1235709_1235911_c" /HighExp="T0.30H, Gly, C90, GM 10, GM 45, M0t90, Lbstat, C30, Lbtran, GM 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigA" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S418" CDS complement(1185483..1186055) /gene="yjbK" /locus_tag="BSU_11580" /old_locus_tag="BSU11580" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9642185, 12456267, 16905149, 20509597, 26904951, 27881678; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="putative RNA/thiamine triphosphatase" /protein_id="NP_389040.1" /db_xref="EnsemblGenomes-Gn:BSU11580" /db_xref="EnsemblGenomes-Tr:CAB13015" /db_xref="GOA:O31609" /db_xref="InterPro:IPR009195" /db_xref="InterPro:IPR023577" /db_xref="InterPro:IPR033469" /db_xref="SubtiList:BG13140" /db_xref="UniProtKB/Swiss-Prot:O31609" /translation="MSQEIEIEFKNMLTKQEFKNIASALQLTEKDFTDQKNHYFDTDS FALKQKHAALRIRRKNGKYVLTLKEPADVGLLETHQQLSEVSDLAGFSVPEGPVKDQL HKLQIDTDAIQYFGSLATNRAEKETEKGLIVLDHSRYLNKEDYEIEFEAADWHEGRQA FEKLLQQFSIPQRETKNKILRFYEEKRKSI*" /label="yjbK CDS" gene complement(1185483..1186055) /gene="yjbK" /locus_tag="BSU_11580" /old_locus_tag="BSU11580" /label="yjbK gene" promotor_-10 complement(1185628..1185646) /Source="Nicolas_upshift_promotors" /id="U938" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2803 /SigmaFactorBS="caaaccgtgcggaaaaagaaacagaaaaaggCTTAATAGttt tagaccacaGCCGATATTTAAATAAAGAggactatgaaattgaatttgaggcggcgga t" /listShort="S418, yjbJ" /listLong="S417, yjbI, yjbH" /label="promotor_-10" upshifts complement(1185637) /Source="Nicolas_upshifts" /id="U938" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2803 /SigmaFactorBS="caaaccgtgcggaaaaagaaacagaaaaaggCTTAATAGttt tagaccacaGCCGATATTTAAATAAAGAggactatgaaattgaatttgaggcggcgga t" /listShort="S418, yjbJ" /listLong="S417, yjbI, yjbH" /label="upshifts" promotor_-35 complement(1185659..1185666) /Source="Nicolas_upshift_promotors" /id="U938" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2803 /SigmaFactorBS="caaaccgtgcggaaaaagaaacagaaaaaggCTTAATAGttt tagaccacaGCCGATATTTAAATAAAGAggactatgaaattgaatttgaggcggcgga t" /listShort="S418, yjbJ" /listLong="S417, yjbI, yjbH" /label="promotor_-35" promotor_-10 complement(1186084..1186103) /Source="Nicolas_upshift_promotors" /id="U939" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.782217782217782" /psig="0.999000999001" /xcortree=2255 /SigmaFactorBS="acaaagtacagattcattttatcatatcgagctcgaTATTGA TAaacctaacatctaaAGAGATAATAGTAAAAATAAgatttacagggcggaaaggaag a" /listShort="yjbK, S418, yjbJ" /listLong="S417, yjbI, yjbH" /label="promotor_-10" upshifts complement(1186101) /Source="Nicolas_upshifts" /id="U939" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.782217782217782" /psig="0.999000999001" /xcortree=2255 /SigmaFactorBS="acaaagtacagattcattttatcatatcgagctcgaTATTGA TAaacctaacatctaaAGAGATAATAGTAAAAATAAgatttacagggcggaaaggaag a" /listShort="yjbK, S418, yjbJ" /listLong="S417, yjbI, yjbH" /label="upshifts" promotor_-35 1186117..1186120 /Source="Nicolas_upshift_promotors" /id="U940" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.534465534465534" /psig="0.994005994005994" /xcortree=2570 /SigmaFactorBS="ccctgtaaatcttatttttactattatctctttagatgttag gtTTATcaatatcgagctcgaTATGATAAAATGAATCTGTActttgtttaaaaaagga g" /listShort="yjbL, yjbM, ppnKA, yjbO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(1186118..1186125) /Source="Nicolas_upshift_promotors" /id="U939" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.782217782217782" /psig="0.999000999001" /xcortree=2255 /SigmaFactorBS="acaaagtacagattcattttatcatatcgagctcgaTATTGA TAaacctaacatctaaAGAGATAATAGTAAAAATAAgatttacagggcggaaaggaag a" /listShort="yjbK, S418, yjbJ" /listLong="S417, yjbI, yjbH" /label="promotor_-35" upshifts 1186133 /Source="Nicolas_upshifts" /id="U940" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.534465534465534" /psig="0.994005994005994" /xcortree=2570 /SigmaFactorBS="ccctgtaaatcttatttttactattatctctttagatgttag gtTTATcaatatcgagctcgaTATGATAAAATGAATCTGTActttgtttaaaaaagga g" /listShort="yjbL, yjbM, ppnKA, yjbO" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1186136..1186155 /Source="Nicolas_upshift_promotors" /id="U940" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.534465534465534" /psig="0.994005994005994" /xcortree=2570 /SigmaFactorBS="ccctgtaaatcttatttttactattatctctttagatgttag gtTTATcaatatcgagctcgaTATGATAAAATGAATCTGTActttgtttaaaaaagga g" /listShort="yjbL, yjbM, ppnKA, yjbO" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1186180..1186548 /gene="yjbL" /locus_tag="BSU_11590" /old_locus_tag="BSU11590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22333191; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389041.1" /db_xref="EnsemblGenomes-Gn:BSU11590" /db_xref="EnsemblGenomes-Tr:CAB13016" /db_xref="InterPro:IPR020908" /db_xref="SubtiList:BG13141" /db_xref="UniProtKB/Swiss-Prot:O31610" /translation="MQNRIEILNATLSDDQLRLACQTEGNEAERKPSGQMLVDSDHFA FVYILELADSFEYVIIKEHVWPELKQAHAQKIPVVLEAGDQTIELAGLHEELEYLLEN IKDNANYGEEMEEKVKRVFL*" /label="yjbL CDS" gene 1186180..1186548 /gene="yjbL" /locus_tag="BSU_11590" /old_locus_tag="BSU11590" /label="yjbL gene" CDS 1186577..1187212 /gene="relP" /locus_tag="BSU_11600" /old_locus_tag="BSU11600" /EC_number="2.7.6.5" /function="16.1: Circulate" /function="16.14: Store" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17714452, 18067544, 19447912, 24163341, 25331430, 26825398" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17714452, 18067544, 19447912, 24163341, 25331430, 26825398; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="(p)ppGpp synthetase" /protein_id="NP_389042.1" /db_xref="EnsemblGenomes-Gn:BSU11600" /db_xref="EnsemblGenomes-Tr:CAB13017" /db_xref="GOA:O31611" /db_xref="InterPro:IPR007685" /db_xref="PDB:5DEC" /db_xref="PDB:5DED" /db_xref="PDB:5F2V" /db_xref="SubtiList:BG13142" /db_xref="UniProtKB/Swiss-Prot:O31611" /translation="MDDKQWERFLVPYRQAVEELKVKLKGIRTLYEYEDDHSPIEFVT GRVKPVASILEKARRKSIPLHEIETMQDIAGLRIMCQFVDDIQIVKEMLFARKDFTVV DQRDYIAEHKESGYRSYHLVVLYPLQTVSGEKHVLVEIQIRTLAMNFWATIEHSLNYK YSGNIPEKVKLRLQRASEAASRLDEEMSEIRGEVQEAQAAFSRKKKGSEQQ*" /label="relP CDS" gene 1186577..1187212 /gene="relP" /locus_tag="BSU_11600" /old_locus_tag="BSU11600" /label="relP gene" CDS 1187231..1188031 /gene="ppnKA" /locus_tag="BSU_11610" /old_locus_tag="BSU11610" /EC_number="2.7.1.23" /function="16.14: Store" /function="16.7: Manage energy" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 12897004, 16233726, 16511117, 18720024, 24048943" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 12897004, 16233726, 16511117, 18720024, 24048943; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="inorganic polyphosphate/ATP-NAD kinase (quinolate activated)" /protein_id="NP_389043.1" /db_xref="EnsemblGenomes-Gn:BSU11610" /db_xref="EnsemblGenomes-Tr:CAB13018" /db_xref="GOA:O31612" /db_xref="InterPro:IPR002504" /db_xref="InterPro:IPR016064" /db_xref="InterPro:IPR017437" /db_xref="InterPro:IPR017438" /db_xref="SubtiList:BG13143" /db_xref="UniProtKB/Swiss-Prot:O31612" /translation="MKFAVSSKGDQVSDTLKSKIQAYLLDFDMELDENEPEIVISVGG DGTLLYAFHRYSDRLDKTAFVGVHTGHLGFYADWVPHEIEKLVLAIAKTPYHTVEYPL LEVIVTYHENEREERYLALNECTIKSIEGSLVADVEIKGQLFETFRGDGLCLSTPSGS TAYNKALGGAIIHPSIRAIQLAEMASINNRVFRTVGSPLLLPSHHDCMIKPRNEVDFQ VTIDHLTLLHKDVKSIRCQVASEKVRFARFRPFPFWKRVQDSFIGKGE*" /label="ppnKA CDS" gene 1187231..1188031 /gene="ppnKA" /locus_tag="BSU_11610" /old_locus_tag="BSU11610" /label="ppnKA gene" CDS 1188094..1188945 /gene="yjbO" /locus_tag="BSU_11620" /old_locus_tag="BSU11620" /EC_number="5.4.99.-" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pseudouridylate synthase" /protein_id="NP_389044.1" /db_xref="EnsemblGenomes-Gn:BSU11620" /db_xref="EnsemblGenomes-Tr:CAB13019" /db_xref="GOA:O31613" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR006145" /db_xref="InterPro:IPR006224" /db_xref="InterPro:IPR006225" /db_xref="InterPro:IPR020103" /db_xref="SubtiList:BG13144" /db_xref="UniProtKB/Swiss-Prot:O31613" /translation="MTVKEYAGELGISKRLLTDIKFGGGDLQINGEHVTVKYVLKEGD LLIVKFPEEQVSETLLAEPVPLDILYEDEHVLVINKQPYVSSIPSREHPSGSIANGII DHYQTTGVRATVHLVTRLDRDTSGIMLVAKHRFAHSILSSAQKNGLVKRRYAAVVHGR MAQMEGTVDAPIGRHPDSIIERTVTPDGQKAVTHFYVTCANDDMTSVALQLETGRTHQ IRVHMSYLGHPLCGDTLYGGTRQEIGRQALHSEHLSFIHPLTQENMRFHAPLPQDMSK LIKGENH*" /label="yjbO CDS" gene 1188094..1188945 /gene="yjbO" /locus_tag="BSU_11620" /old_locus_tag="BSU11620" /label="yjbO gene" downshifts 1188904 /Source="Nicolas_upshifts" /id="D632" /incds=0 /nref=203 /ntot=256 /MaxReadThrough="0.25796" /MaxDrop="5.73002" /score="21.4914497" /energy="-12.8" /TU="NA" /idTUdmin="U940" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1188958..1189692) /gene="prpE" /locus_tag="BSU_11630" /old_locus_tag="BSU11630" /EC_number="3.6.1.17" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12059787, 16740944, 21092197, 23824080, 28516732" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12059787, 16740944, 21092197, 23824080, 28516732; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphorylated protein phosphatase E and diadenosine-polyphosphate hydrolase" /protein_id="NP_389045.1" /db_xref="EnsemblGenomes-Gn:BSU11630" /db_xref="EnsemblGenomes-Tr:CAB13020" /db_xref="GOA:O31614" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR023937" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG13145" /db_xref="UniProtKB/Swiss-Prot:O31614" /translation="MAYDIISDIHGCYDEMTALIQKLGYTIKNGVPVHEEGRVLVFAG DLTDRGPKSIEVIRFVAGAYEKGAVRYVPGNHCNKLYRYLKGNPVKVMHGLETTAAEL EELSKDEKKSVSEQFMKLYETAPLYDILHNGELVVAHAGIRADDIGKYTRRVKDFVLY GDVTGETYPDGRPIRRDWAAAYNGKAWVVYGHTPVKEPRKVNRTINIDTGCVFGNQLT GFRFPEIETVSVPSSLPYDESRFRPI*" /label="prpE CDS" gene complement(1188958..1189692) /gene="prpE" /locus_tag="BSU_11630" /old_locus_tag="BSU11630" /label="prpE gene" downshifts complement(1188980) /Source="Nicolas_upshifts" /id="D633" /incds=0 /nref=22 /ntot=152 /MaxReadThrough="1.18091" /MaxDrop="3.57735" /score="3.24324561" /energy="-12.8" /TU="NA" /idTUdmin="U938" /TUdmin="-4312" /isTUend="FALSE" /label="downshifts" promotor_-35 1189814..1189818 /Source="Nicolas_upshift_promotors" /id="U941" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.768231768231768" /psig="0.996003996003996" /xcortree=1820 /SigmaFactorBS="ttctaaacaggattaagaccttatcACTTTatttttcatcat caccCTTGTTAAAATCGCGTTATGttttttaaaaatgaggttttgttctctgagtgag a" /listShort="S419, yjbQ, NA" /listLong="tenA, tenI, thiO, thiS, thiG, thiF, thiD, fabI" /label="promotor_-35" promotor_-10 1189835..1189854 /Source="Nicolas_upshift_promotors" /id="U941" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.768231768231768" /psig="0.996003996003996" /xcortree=1820 /SigmaFactorBS="ttctaaacaggattaagaccttatcACTTTatttttcatcat caccCTTGTTAAAATCGCGTTATGttttttaaaaatgaggttttgttctctgagtgag a" /listShort="S419, yjbQ, NA" /listLong="tenA, tenI, thiO, thiS, thiG, thiF, thiD, fabI" /label="promotor_-10" upshifts 1189849 /Source="Nicolas_upshifts" /id="U941" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.768231768231768" /psig="0.996003996003996" /xcortree=1820 /SigmaFactorBS="ttctaaacaggattaagaccttatcACTTTatttttcatcat caccCTTGTTAAAATCGCGTTATGttttttaaaaatgaggttttgttctctgagtgag a" /listShort="S419, yjbQ, NA" /listLong="tenA, tenI, thiO, thiS, thiG, thiF, thiD, fabI" /label="upshifts" S_feature 1189850..1189926 /Source="Nicolas_S_feature" /locus_tag="new_1240279_1240355" /HighExp="H2O2, Diami, dia15, Paraq, Oxctl, Heat, G180, Salt, BMM, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S419" CDS 1189927..1191771 /gene="kefQ" /locus_tag="BSU_11640" /old_locus_tag="BSU11640" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16850406, 21742892, 24330391; Product type t: transporter" /codon_start=1 /transl_table=11 /product="gated K+/H+ antiporter" /protein_id="NP_389046.1" /db_xref="EnsemblGenomes-Gn:BSU11640" /db_xref="EnsemblGenomes-Tr:CAB13021" /db_xref="GOA:O31615" /db_xref="InterPro:IPR003148" /db_xref="InterPro:IPR006037" /db_xref="InterPro:IPR006153" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR036721" /db_xref="SubtiList:BG13146" /db_xref="UniProtKB/Swiss-Prot:O31615" /translation="MAHTSVASLVVVLIVAFLTPILLHRFKLSIPVVVAEIIMGLIIG KSGLNLVVEGDTWLQTLSMLGFIFLMFLSGLEIDFSSFEKGKKKQFLPNGKEAPNTFA AASVIFVGIFILSLLLSYGFVLAGFIQNAFLMTLIISTISLGVVVPTLKEERIMNSNI GQIILLVAVIADLATMILLAVFSSLYGEDSGNMWLLMILFAAGVVLYFFGRVFKHRSF VQSMSKGTIQIGTRAIFTLIIVLVALSESLGAENILGAFLAGVLVSLLSPNKELVQQL DSFGYGFLIPIFFVMVGVKLDIWTLFQDKTILIMIPLLLLALLVSKIIPVMYLKKWYD NRTIFASGFLLTSTLSLVIAAATIGQQLHVISTNMSGALILVAVIASIFTPICFKKLY KREEQPEEKKTITFIGANQMTLPVTLELPEEEYDVRVVHVYQENAEEKLSESVFAVET ISDYEHETLESLGIFETDILVVATGNEDMNADIALLAKDKGTERVIASVGSPEHEAAL KEQGISIFSILLSTKTLLRALIEAPGVMKLLTNQESSLYQINMENSKYDGVILREFPL TGDVIFVRIFRGVDSIVPHGDTRLKLGDRLIVTGSRGYVTDLKKTLEG*" /label="kefQ CDS" gene 1189927..1191771 /gene="kefQ" /locus_tag="BSU_11640" /old_locus_tag="BSU11640" /label="kefQ gene" misc_feature complement(1190254..1190273) /Source="Nicolas_upshift_promotors" /id="U942" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig="0.996003996003996" /xcortree=3108 /SigmaFactorBS="taatcagggtcatcaaaaatgcattttggataaatccggcca agacgaacccataggacaagagcAATGATAAAATAAAAATACCgacgaaaataacaga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1190278) /Source="Nicolas_upshifts" /id="U942" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig="0.996003996003996" /xcortree=3108 /SigmaFactorBS="taatcagggtcatcaaaaatgcattttggataaatccggcca agacgaacccataggacaagagcAATGATAAAATAAAAATACCgacgaaaataacaga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1191773..1191780 /Source="Nicolas_upshift_promotors" /id="U943" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.878121878121878" /psig="0.999000999001" /xcortree=2884 /SigmaFactorBS="taacggatcttaagaaaacattggaaggataaaTCTTGACCa aataaggattcgTGTTAATATAGAGGTGCAGAacaattcaatatgtattcgtttaacc a" /listShort="NA, tenA, tenI, thiO, thiS, thiG, thiF, thiD" /listLong="fabI" /label="promotor_-35" promotor_-10 1191794..1191813 /Source="Nicolas_upshift_promotors" /id="U943" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.878121878121878" /psig="0.999000999001" /xcortree=2884 /SigmaFactorBS="taacggatcttaagaaaacattggaaggataaaTCTTGACCa aataaggattcgTGTTAATATAGAGGTGCAGAacaattcaatatgtattcgtttaacc a" /listShort="NA, tenA, tenI, thiO, thiS, thiG, thiF, thiD" /listLong="fabI" /label="promotor_-10" upshifts 1191800 /Source="Nicolas_upshifts" /id="U943" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.878121878121878" /psig="0.999000999001" /xcortree=2884 /SigmaFactorBS="taacggatcttaagaaaacattggaaggataaaTCTTGACCa aataaggattcgTGTTAATATAGAGGTGCAGAacaattcaatatgtattcgtttaacc a" /listShort="NA, tenA, tenI, thiO, thiS, thiG, thiF, thiD" /listLong="fabI" /label="upshifts" misc_RNA 1191833..1191941 /gene="tswA" /locus_tag="BSU_misc_RNA_14" /product="thiamine pyrophosphate riboswitch" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11470904, 12410317, 15862294, 16728979, 16962976, 17307816, 18179415, 18776013; Product type n: RNA" /function="16.3: Control" /label="tswA RNA" gene 1191833..1191941 /gene="tswA" /locus_tag="BSU_misc_RNA_14" /label="tswA gene" downshifts 1191936 /Source="Nicolas_upshifts" /id="D634" /incds=0 /nref=20 /ntot=84 /MaxReadThrough="7.67021" /MaxDrop="5.27759" /score="34.8346124" /energy="-12.5" /TU="U943" /idTUdmin="U941" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS 1192020..1192730 /gene="tenA" /locus_tag="BSU_11650" /old_locus_tag="BSU11650" /EC_number="3.5.99.2" /function="4.11: Thiamine" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15709744, 15858269, 16356850, 17618314, 18054064, 24311574" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15709744, 15858269, 16356850, 17618314, 18054064, 24311574; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="thiaminase II" /protein_id="NP_389047.1" /db_xref="EnsemblGenomes-Gn:BSU11650" /db_xref="EnsemblGenomes-Tr:CAB13022" /db_xref="GOA:P25052" /db_xref="InterPro:IPR004305" /db_xref="InterPro:IPR016084" /db_xref="InterPro:IPR027574" /db_xref="PDB:1TO9" /db_xref="PDB:1TYH" /db_xref="PDB:1YAF" /db_xref="PDB:1YAK" /db_xref="PDB:2QCX" /db_xref="SubtiList:BG10791" /db_xref="UniProtKB/Swiss-Prot:P25052" /translation="MKFSEECRSAAAEWWEGSFVHPFVQGIGDGTLPIDRFKYYVLQD SYYLTHFAKVQSFGAAYAKDLYTTGRMASHAQGTYEAEMALHREFAELLEISEEERKA FKPSPTAYSYTSHMYRSVLSGNFAEILAALLPCYWLYYEVGEKLLHCDPGHPIYQKWI GTYGGDWFRQQVEEQINRFDELAENSTEEVRAKMKENFVISSYYEYQFWGMAYRKEGW SDSAIKEVEECGASRHNG*" /label="tenA CDS" gene 1192020..1192730 /gene="tenA" /locus_tag="BSU_11650" /old_locus_tag="BSU11650" /label="tenA gene" CDS 1192705..1193322 /gene="tenI" /locus_tag="BSU_11660" /old_locus_tag="BSU11660" /EC_number="5.3.99.10" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15709744, 15858269, 16356850, 21534620" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15709744, 15858269, 16356850, 21534620; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thiazole tautomerase" /protein_id="NP_389048.1" /db_xref="EnsemblGenomes-Gn:BSU11660" /db_xref="EnsemblGenomes-Tr:CAB13023" /db_xref="GOA:P25053" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR022998" /db_xref="InterPro:IPR036206" /db_xref="PDB:1YAD" /db_xref="PDB:3QH2" /db_xref="SubtiList:BG10792" /db_xref="UniProtKB/Swiss-Prot:P25053" /translation="MELHAITDDSKPVEELARIIITIQNEVDFIHIRERSKSAADILK LLDLIFEGGIDKRKLVMNGRVDIALFSTIHRVQLPSGSFSPKQIRARFPHLHIGRSVH SLEEAVQAEKEDADYVLFGHVFETDCKKGLEGRGVSLLSDIKQRISIPVIAIGGMTPD RLRDVKQAGADGIAVMSGIFSSAEPLEAARRYSRKLKEMRYEKAL*" /label="tenI CDS" gene 1192705..1193322 /gene="tenI" /locus_tag="BSU_11660" /old_locus_tag="BSU11660" /label="tenI gene" CDS 1193306..1194415 /gene="thiO" /locus_tag="BSU_11670" /old_locus_tag="BSU11670" /EC_number="1.4.3.19" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9827558, 11744710, 12627963, 15105420, 19751796, 26443755" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9827558, 11744710, 12627963, 15105420, 19751796, 26443755; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="FAD-dependent glycine oxidase" /protein_id="NP_389049.1" /db_xref="EnsemblGenomes-Gn:BSU11670" /db_xref="EnsemblGenomes-Tr:CAB13024" /db_xref="GOA:O31616" /db_xref="InterPro:IPR006076" /db_xref="InterPro:IPR012727" /db_xref="InterPro:IPR036188" /db_xref="PDB:1NG3" /db_xref="PDB:1NG4" /db_xref="PDB:1RYI" /db_xref="PDB:3IF9" /db_xref="SubtiList:BG13147" /db_xref="UniProtKB/Swiss-Prot:O31616" /translation="MKRHYEAVVIGGGIIGSAIAYYLAKENKNTALFESGTMGGRTTS AAAGMLGAHAECEERDAFFDFAMHSQRLYKGLGEELYALSGVDIRQHNGGMFKLAFSE EDVLQLRQMDDLDSVSWYSKEEVLEKEPYASGDIFGASFIQDDVHVEPYFVCKAYVKA AKMLGAEIFEHTPVLHVERDGEALFIKTPSGDVWANHVVVASGVWSGMFFKQLGLNNA FLPVKGECLSVWNDDIPLTKTLYHDHCYIVPRKSGRLVVGATMKPGDWSETPDLGGLE SVMKKAKTMLPAIQNMKVDRFWAGLRPGTKDGKPYIGRHPEDSRILFAAGHFRNGILL APATGALISDLIMNKEVNQDWLHAFRIDRKEAVQI*" /label="thiO CDS" gene 1193306..1194415 /gene="thiO" /locus_tag="BSU_11670" /old_locus_tag="BSU11670" /label="thiO gene" CDS 1194415..1194615 /gene="thiS" /locus_tag="BSU_11680" /old_locus_tag="BSU11680" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10939241, 14567704, 14757766, 15489164, 22616866, 26443755; Product type c : carrier" /codon_start=1 /transl_table=11 /product="sulfur carrier for synthesis of hydroxyethylthiazole phosphate" /protein_id="NP_389050.1" /db_xref="EnsemblGenomes-Gn:BSU11680" /db_xref="EnsemblGenomes-Tr:CAB13025" /db_xref="GOA:O31617" /db_xref="InterPro:IPR003749" /db_xref="InterPro:IPR010035" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR016155" /db_xref="PDB:1TYG" /db_xref="SubtiList:BG13148" /db_xref="UniProtKB/Swiss-Prot:O31617" /translation="MLQLNGKDVKWKKDTGTIQDLLASYQLENKIVIVERNKEIIGKE RYHEVELCDRDVIEIVHFVGGG*" /label="thiS CDS" gene 1194415..1194615 /gene="thiS" /locus_tag="BSU_11680" /old_locus_tag="BSU11680" /label="thiS gene" CDS 1194612..1195382 /gene="thiG" /locus_tag="BSU_11690" /old_locus_tag="BSU11690" /EC_number="2.8.1.10" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 12627963, 14567704, 14757766, 15489164, 22938038" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 12627963, 14567704, 14757766, 15489164, 22938038; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="hydroxyethylthiazole phosphate synthetase (thiamine biosynthesis)" /protein_id="NP_389051.1" /db_xref="EnsemblGenomes-Gn:BSU11690" /db_xref="EnsemblGenomes-Tr:CAB13026" /db_xref="GOA:O31618" /db_xref="InterPro:IPR008867" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR033983" /db_xref="PDB:1TYG" /db_xref="PDB:1XM3" /db_xref="SubtiList:BG13149" /db_xref="UniProtKB/Swiss-Prot:O31618" /translation="MSMLTIGGKSFQSRLLLGTGKYPSFDIQKEAVAVSESDILTFAV RRMNIFEASQPNFLEQLDLSKYTLLPNTAGASTAEEAVRIARLAKASGLCDMIKVEVI GCSRSLLPDPVETLKASEQLLEEGFIVLPYTSDDVVLARKLEELGVHAIMPGASPIGS GQGILNPLNLSFIIEQAKVPVIVDAGIGSPKDAAYAMELGADGVLLNTAVSGADDPVK MARAMKLAVEAGRLSYEAGRIPLKQYGTASSPGEGLPV*" /label="thiG CDS" gene 1194612..1195382 /gene="thiG" /locus_tag="BSU_11690" /old_locus_tag="BSU11690" /label="thiG gene" CDS 1195379..1196389 /gene="thiF" /locus_tag="BSU_11700" /old_locus_tag="BSU11700" /EC_number="2.7.7.73" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 14567704, 14757766, 15489164, 16388576, 26443755" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 14567704, 14757766, 15489164, 16388576, 26443755; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="adenylate transferase and sulfur transferase (thiamine biosynthesis)" /protein_id="NP_389052.1" /db_xref="EnsemblGenomes-Gn:BSU11700" /db_xref="EnsemblGenomes-Tr:CAB13027" /db_xref="GOA:O31619" /db_xref="InterPro:IPR000594" /db_xref="InterPro:IPR035985" /db_xref="SubtiList:BG13150" /db_xref="UniProtKB/Swiss-Prot:O31619" /translation="MTGRYSRQELFAPIGPSGQKKLKEARAVIIGAGALGTASAEMLV RAGVGSVKIADRDYVEWSNLQRQQLYTEDDVKKEMPKAAAAERRLRSINSDVDVTGLV MDVTAENIFELIRDASIIVDAADNFETRLIVNDAAVKEGIPFLYGACVGSYGLTFTVV PGSTPCLHCLLDALPIGGATCDTAGIISPAVLQVAVFQVTDALKLLTGEECEPVLRSF DLWKNERSEVRAASLKHDACPSCGTKDFPFLSYENQTKAAVLCGRNTVQIRSSITKEA DLEALAGQLRQAGLEVAANPYLISCRSDDMKMVLFRDGRALIHGTNDIARAKSIYHKW IG*" /label="thiF CDS" gene 1195379..1196389 /gene="thiF" /locus_tag="BSU_11700" /old_locus_tag="BSU11700" /label="thiF gene" CDS 1196408..1197223 /gene="thiD" /locus_tag="BSU_11710" /old_locus_tag="BSU11710" /EC_number="2.7.4.7" /EC_number="2.7.1.49" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 12627963, 14973012, 16952958, 17012797, 26443755" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 12627963, 14973012, 16952958, 17012797, 26443755; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="phosphomethylpyrimidine kinase, 4-amino-5-hydroxymethyl-2-methylpyrimidine and 4-amino-5-hydroxymethyl-2-methylpyrimidine pyrophosphate kinase" /protein_id="NP_389053.1" /db_xref="EnsemblGenomes-Gn:BSU11710" /db_xref="EnsemblGenomes-Tr:CAB13028" /db_xref="GOA:O31620" /db_xref="InterPro:IPR004399" /db_xref="InterPro:IPR013749" /db_xref="InterPro:IPR029056" /db_xref="SubtiList:BG13151" /db_xref="UniProtKB/Swiss-Prot:O31620" /translation="MSIYKALTIAGSDSGGGAGIQADIKTFQELDVFGMSAITAVTAQ NTLGVHGVHPLTVETLRQQIDAVAEDLRPDAVKTGMLWNADMIEEVARKIDEYGFNRV IVDPVMIAKGGASLLRDESVATLKELLIPRSYAITPNVPEAETLTGMTISSLDDRKKA AEQLVKMGAQHVIIKGGHQPEDNHITDLLFDGSMFMQITHPYINTKHTHGTGCTFAAA LTAQTAKGDSIHQAFEVAANFVREAVENTLGIGSGHGPTNHFAFKRNSLNTSR*" /label="thiD CDS" gene 1196408..1197223 /gene="thiD" /locus_tag="BSU_11710" /old_locus_tag="BSU11710" /label="thiD gene" downshifts 1197197 /Source="Nicolas_upshifts" /id="D635" /incds=0 /nref=128 /ntot=172 /MaxReadThrough="3.33485" /MaxDrop="5.0154" /score="3.40314581" /energy="-14.8" /TU="U943" /idTUdmin="U943" /TUdmin="-89" /isTUend="FALSE" /label="downshifts" promotor_-35 1197270..1197276 /Source="Nicolas_upshift_promotors" /id="U944" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.619380619380619" /psig=1 /xcortree=2189 /SigmaFactorBS="gtgatctcttttgcgtttgctacggtatgcgCTTTTCAtctg gacaaggtTATGATATGATAGGAATTAAgatcaggtactaatactatgtctttattaa a" /listShort="fabI, cotO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1197289..1197308 /Source="Nicolas_upshift_promotors" /id="U944" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.619380619380619" /psig=1 /xcortree=2189 /SigmaFactorBS="gtgatctcttttgcgtttgctacggtatgcgCTTTTCAtctg gacaaggtTATGATATGATAGGAATTAAgatcaggtactaatactatgtctttattaa a" /listShort="fabI, cotO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1197299 /Source="Nicolas_upshifts" /id="U944" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.619380619380619" /psig=1 /xcortree=2189 /SigmaFactorBS="gtgatctcttttgcgtttgctacggtatgcgCTTTTCAtctg gacaaggtTATGATATGATAGGAATTAAgatcaggtactaatactatgtctttattaa a" /listShort="fabI, cotO" /GFF_Attribute="listLong" /label="upshifts" CDS 1197359..1198135 /gene="fabI" /locus_tag="BSU_11720" /old_locus_tag="BSU11720" /EC_number="1.3.1.9" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11007778, 15105103, 21185310, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11007778, 15105103, 21185310, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enoyl-acyl carrier protein reductase" /protein_id="NP_389054.2" /db_xref="EnsemblGenomes-Gn:BSU11720" /db_xref="EnsemblGenomes-Tr:CAB13029" /db_xref="GOA:P54616" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR014358" /db_xref="InterPro:IPR036291" /db_xref="PDB:3OIF" /db_xref="PDB:3OIG" /db_xref="SubtiList:BG13152" /db_xref="UniProtKB/Swiss-Prot:P54616" /translation="MNFSLEGRNIVVMGVANKRSIAWGIARSLHEAGARLIFTYAGER LEKSVHELAGTLDRNDSIILPCDVTNDAEIETCFASIKEQVGVIHGIAHCIAFANKEE LVGEYLNTNRDGFLLAHNISSYSLTAVVKAARPMMTEGGSIVTLTYLGGELVMPNYNV MGVAKASLDASVKYLAADLGKENIRVNSISAGPIRTLSAKGISDFNSILKDIEERAPL RRTTTPEEVGDTAAFLFSDMSRGITGENLHVDSGFHITAR*" /label="fabI CDS" gene 1197359..1198135 /gene="fabI" /locus_tag="BSU_11720" /old_locus_tag="BSU11720" /label="fabI gene" downshifts 1198124 /Source="Nicolas_upshifts" /id="D636" /incds=0 /nref=229 /ntot=313 /MaxReadThrough="3.12901" /MaxDrop="6.64182" /score="33.5478109" /energy="-11.8" /TU="U944" /idTUdmin="U944" /TUdmin="-416" /isTUend="FALSE" /label="downshifts" promotor_-35 1198183..1198188 /Source="Nicolas_upshift_promotors" /id="U945" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.968031968031968" /psig="0.968031968031968" /xcortree=1095 /SigmaFactorBS="tcaagcaatcccgaatagggattgcttttttatttCTTCTGa ttttcagctttctgTCATATAGATAGAATATGAcacaatcggagggatgaagatgtct a" /listShort="cotO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1198204..1198222 /Source="Nicolas_upshift_promotors" /id="U945" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.968031968031968" /psig="0.968031968031968" /xcortree=1095 /SigmaFactorBS="tcaagcaatcccgaatagggattgcttttttatttCTTCTGa ttttcagctttctgTCATATAGATAGAATATGAcacaatcggagggatgaagatgtct a" /listShort="cotO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1198208 /Source="Nicolas_upshifts" /id="U945" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.968031968031968" /psig="0.968031968031968" /xcortree=1095 /SigmaFactorBS="tcaagcaatcccgaatagggattgcttttttatttCTTCTGa ttttcagctttctgTCATATAGATAGAATATGAcacaatcggagggatgaagatgtct a" /listShort="cotO" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1198220..1198234) /Source="Nicolas_upshift_promotors" /id="U946" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.997002997002997" /psig="0.001998001998002" /xcortree=1241 /SigmaFactorBS="gagcggttttttatccgcgtttcttttcttattaGACATctt catcCCTCCGATTGTGTCAtattctatctatatgacagaaagctgaaaatcagaagaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1198220) /Source="Nicolas_upshifts" /id="U946" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.997002997002997" /psig="0.001998001998002" /xcortree=1241 /SigmaFactorBS="gagcggttttttatccgcgtttcttttcttattaGACATctt catcCCTCCGATTGTGTCAtattctatctatatgacagaaagctgaaaatcagaagaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 1198236..1198919 /gene="cotO" /locus_tag="BSU_11730" /old_locus_tag="BSU11730" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:16321932" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16321932; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore outer coat protein" /protein_id="NP_389055.1" /db_xref="EnsemblGenomes-Gn:BSU11730" /db_xref="EnsemblGenomes-Tr:CAB13030" /db_xref="GOA:O31622" /db_xref="InterPro:IPR025439" /db_xref="SubtiList:BG13153" /db_xref="UniProtKB/Swiss-Prot:O31622" /translation="MKMSNKKRNADKKPLMYIVQPDYAETTRSSMQEIVIKRKADKPA PPKAEEKPAYHEKQQEEAVAQDVLQEDQKPAAEPVSQQTQEAREPENIKSQEEQKAEP QAVEETVEHEPPKAEKKEEPALEARKPEKEPEAVHSADKAEEKAPPARKVKKPMSKMT IHEKIDFLTKLPHNMPRALCLIEANGRTYRGVIVGRRNDSVLLRTTGNGAPTELAIDD ITSLHPLGF*" /label="cotO CDS" gene 1198236..1198919 /gene="cotO" /locus_tag="BSU_11730" /old_locus_tag="BSU11730" /label="cotO gene" promotor_-35 complement(1198242..1198246) /Source="Nicolas_upshift_promotors" /id="U946" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.997002997002997" /psig="0.001998001998002" /xcortree=1241 /SigmaFactorBS="gagcggttttttatccgcgtttcttttcttattaGACATctt catcCCTCCGATTGTGTCAtattctatctatatgacagaaagctgaaaatcagaagaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1198914 /Source="Nicolas_upshifts" /id="D637" /incds=0 /nref=4 /ntot=40 /MaxReadThrough="3.37645" /MaxDrop="4.6587" /score="18.0229289" /energy="-13.4" /TU="U945" /idTUdmin="U945" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" downshifts 1199002 /Source="Nicolas_upshifts" /id="D638" /incds=0 /nref=1 /ntot=29 /MaxReadThrough="2.44926" /MaxDrop="4.55934" /score="18.0229289" /energy="-13.4" /TU="NA" /idTUdmin="U945" /TUdmin=22 /isTUend="TRUE" /label="downshifts" CDS complement(1199013..1199459) /gene="cotZ" /locus_tag="BSU_11740" /old_locus_tag="BSU11740" /function="16.13: Shape" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:7519271, 8509331, 19933362, 26341943, 27320701" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7519271, 8509331, 19933362, 26341943, 27320701; Product type s: structure" /codon_start=1 /transl_table=11 /product="spore coat protein (insoluble fraction, crust layer)" /protein_id="NP_389056.1" /db_xref="EnsemblGenomes-Gn:BSU11740" /db_xref="EnsemblGenomes-Tr:CAB13031" /db_xref="GOA:Q08312" /db_xref="InterPro:IPR019593" /db_xref="SubtiList:BG10499" /db_xref="UniProtKB/Swiss-Prot:Q08312" /translation="MSQKTSSCVREAVENIEDLQNAVEEDCPTGCHSKLLSVSHSLGD TVPFAIFTSKSTPLVAFGNVGELDNGPCFNTVFFRVERVHGSCATLSLLIAFDEHKHI LDFTDKDTVCEVFRLEKTNYCIEVDLDCFCAINCLNPRLINRTHHH*" /label="cotZ CDS" gene complement(1199013..1199459) /gene="cotZ" /locus_tag="BSU_11740" /old_locus_tag="BSU11740" /label="cotZ gene" downshifts complement(1199034) /Source="Nicolas_upshifts" /id="D639" /incds=0 /nref=7 /ntot=50 /MaxReadThrough="8.44444" /MaxDrop="7.17581" /score="2.03943557" /energy="-9.3" /TU="U949" /idTUdmin="U950" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1199460..1199586) /Source="Nicolas_S_feature" /locus_tag="new_1249889_1250015_c" /HighExp="S8, S7, S6, BT, S5, B36, G/S, Pyr, B60, SMMPr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigEF" /TUshortPSig="1, 0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S420" CDS complement(1199587..1200075) /gene="cotY" /locus_tag="BSU_11750" /old_locus_tag="BSU11750" /function="16.13: Shape" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:7519271, 8509331, 14766913, 26341943, 26821119" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7519271, 8509331, 14766913, 26341943, 26821119; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="outer spore coat protein (crust layer, insolublefraction)" /protein_id="NP_389057.1" /db_xref="EnsemblGenomes-Gn:BSU11750" /db_xref="EnsemblGenomes-Tr:CAB13032" /db_xref="GOA:Q08311" /db_xref="InterPro:IPR019593" /db_xref="SubtiList:BG10498" /db_xref="UniProtKB/Swiss-Prot:Q08311" /translation="MSCGKTHGRHENCVCDAVEKILAEQEAVEEQCPTGCYTNLLNPT IAGKDTIPFLVFDKKGGLFSTFGNVGGFVDDMQCFESIFFRVEKLCDCCATLSILRPV DVKGDTLSVCHPCDPDFFGLEKTDFCIEVDLGCFCAIQCLSPELVDRTSPHKDKKHHH NG*" /label="cotY CDS" gene complement(1199587..1200075) /gene="cotY" /locus_tag="BSU_11750" /old_locus_tag="BSU11750" /label="cotY gene" promotor_-35 1199755..1199761 /Source="Nicolas_upshift_promotors" /id="U947" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.53046953046953" /psig="0.653346653346653" /xcortree=1630 /SigmaFactorBS="agggtggcaaacacttaaggtATCGCCTttgacatcgaccgg GCGTAAAATAGACAGTGTTGcacagcaatcgcataatttttcgacgcggaagaaaatg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1199776..1199795 /Source="Nicolas_upshift_promotors" /id="U947" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.53046953046953" /psig="0.653346653346653" /xcortree=1630 /SigmaFactorBS="agggtggcaaacacttaaggtATCGCCTttgacatcgaccgg GCGTAAAATAGACAGTGTTGcacagcaatcgcataatttttcgacgcggaagaaaatg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1199794 /Source="Nicolas_upshifts" /id="U947" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.53046953046953" /psig="0.653346653346653" /xcortree=1630 /SigmaFactorBS="agggtggcaaacacttaaggtATCGCCTttgacatcgaccgg GCGTAAAATAGACAGTGTTGcacagcaatcgcataatttttcgacgcggaagaaaatg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1200071..1200075 /Source="Nicolas_upshift_promotors" /id="U948" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.997002997002997" /psig="0.002997002997003" /xcortree=1244 /SigmaFactorBS="tctcatgccggccatgggtttttccgcagCTCATtgatttca GCTCCTTCTTTATAGggtatttgactttagtccttaacaacatatgtacccgtgcccc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1200084..1200098 /Source="Nicolas_upshift_promotors" /id="U948" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.997002997002997" /psig="0.002997002997003" /xcortree=1244 /SigmaFactorBS="tctcatgccggccatgggtttttccgcagCTCATtgatttca GCTCCTTCTTTATAGggtatttgactttagtccttaacaacatatgtacccgtgcccc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1200102 /Source="Nicolas_upshifts" /id="U948" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.997002997002997" /psig="0.002997002997003" /xcortree=1244 /SigmaFactorBS="tctcatgccggccatgggtttttccgcagCTCATtgatttca GCTCCTTCTTTATAGggtatttgactttagtccttaacaacatatgtacccgtgcccc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1200112..1200131) /Source="Nicolas_upshift_promotors" /id="U949" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1280 /SigmaFactorBS="tattttccaagcatatgatgaatatatagacgttcACCCACA CCAagtggggcacgggTACATATGTTGTTAAGGACTaaagtcaaataccctataaaga a" /listShort="cotY, S420, cotZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1200129) /Source="Nicolas_upshifts" /id="U949" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1280 /SigmaFactorBS="tattttccaagcatatgatgaatatatagacgttcACCCACA CCAagtggggcacgggTACATATGTTGTTAAGGACTaaagtcaaataccctataaaga a" /listShort="cotY, S420, cotZ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1200145..1200154) /Source="Nicolas_upshift_promotors" /id="U949" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1280 /SigmaFactorBS="tattttccaagcatatgatgaatatatagacgttcACCCACA CCAagtggggcacgggTACATATGTTGTTAAGGACTaaagtcaaataccctataaaga a" /listShort="cotY, S420, cotZ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1200161..1200179) /Source="Nicolas_upshift_promotors" /id="U950" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1006 /SigmaFactorBS="cttgtcctctaggacctaaaagcagagctaaaaacgctCTGC TTtttcttattttccaaGCATATGATGAATATATAGacgttcacccacaccaagtggg g" /listShort="cotY, S420, cotZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1200178) /Source="Nicolas_upshifts" /id="U950" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1006 /SigmaFactorBS="cttgtcctctaggacctaaaagcagagctaaaaacgctCTGC TTtttcttattttccaaGCATATGATGAATATATAGacgttcacccacaccaagtggg g" /listShort="cotY, S420, cotZ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1200195..1200200) /Source="Nicolas_upshift_promotors" /id="U950" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1006 /SigmaFactorBS="cttgtcctctaggacctaaaagcagagctaaaaacgctCTGC TTtttcttattttccaaGCATATGATGAATATATAGacgttcacccacaccaagtggg g" /listShort="cotY, S420, cotZ" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1200212 /Source="Nicolas_upshifts" /id="D640" /incds=0 /nref=1 /ntot=14 /MaxReadThrough="1.28604" /MaxDrop="4.18677" /score="-9.76125107" /energy="-10.4" /TU="NA" /idTUdmin="U948" /TUdmin=22 /isTUend="TRUE" /label="downshifts" CDS complement(1200227..1200745) /gene="cotX" /locus_tag="BSU_11760" /old_locus_tag="BSU11760" /function="16.13: Shape" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:7519271, 8509331, 10400595, 10788508, 12031481, 19304857, 26821119" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7519271, 8509331, 10400595, 10788508, 12031481, 19304857, 26821119; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat protein (insoluble fraction)" /protein_id="NP_389058.1" /db_xref="EnsemblGenomes-Gn:BSU11760" /db_xref="EnsemblGenomes-Tr:CAB13033" /db_xref="GOA:Q08313" /db_xref="InterPro:IPR011428" /db_xref="SubtiList:BG10500" /db_xref="UniProtKB/Swiss-Prot:Q08313" /translation="MESRPYSWVALDPDCDHPLDDKEKDKEKHERKCHCDVCCNGNGF FGNDNAFIDQDLAQANLNKQVSDETIIIRDSCDINVTSTDVQAVTSVVTALNAAVVTA TLTSIADGVIAELVAQDLLQLTANKQVNRQKLLIECSRGVNVTTVDADIATLISTATN TLVAILVITLVL*" /label="cotX CDS" gene complement(1200227..1200745) /gene="cotX" /locus_tag="BSU_11760" /old_locus_tag="BSU11760" /label="cotX gene" downshifts complement(1200251) /Source="Nicolas_upshifts" /id="D641" /incds=0 /nref=76 /ntot=102 /MaxReadThrough="1.79219" /MaxDrop="8.69761" /score="18.5755652" /energy="-10.4" /TU="U952" /idTUdmin="U952" /TUdmin="-29" /isTUend="FALSE" /label="downshifts" downshifts 1200256 /Source="Nicolas_upshifts" /id="D642" /incds=0 /nref=1 /ntot=8 /MaxReadThrough="1.2156" /MaxDrop="3.69222" /score="-9.76125107" /energy="-10.4" /TU="NA" /idTUdmin="U948" /TUdmin=66 /isTUend="FALSE" /label="downshifts" S_feature complement(1200746..1200843) /Source="Nicolas_S_feature" /locus_tag="new_1251175_1251272_c" /HighExp="S8, S7, S6, BT, B36, G/S, Pyr, S5, B60, SMMPr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.748" /TUlongSig="SigK" /TUlongPSig="0.98" /label="S421" CDS complement(1200844..1201161) /gene="cotW" /locus_tag="BSU_11770" /old_locus_tag="BSU11770" /function="16.5: Explore" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8509331, 19304857, 21665972, 25872412" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8509331, 19304857, 21665972, 25872412; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat protein (outemost layer)" /protein_id="NP_389059.1" /db_xref="EnsemblGenomes-Gn:BSU11770" /db_xref="EnsemblGenomes-Tr:CAB13034" /db_xref="GOA:Q08310" /db_xref="SubtiList:BG10497" /db_xref="UniProtKB/Swiss-Prot:Q08310" /translation="MSDNDKFKEELAKLPEVDPMTKMLVQNIFSKHGVTKDKMKKVSD EEKEMLLNLVKDLQAKSQALIENQKKKKEEAAAQEQKNTKPLSRREQLIEQIRQRRKN DNN*" /label="cotW CDS" gene complement(1200844..1201161) /gene="cotW" /locus_tag="BSU_11770" /old_locus_tag="BSU11770" /label="cotW gene" CDS complement(1201202..1201588) /gene="cotV" /locus_tag="BSU_11780" /old_locus_tag="BSU11780" /function="16.13: Shape" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:7519271, 8509331" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7519271, 8509331; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat protein (insoluble fraction)" /protein_id="NP_389060.1" /db_xref="EnsemblGenomes-Gn:BSU11780" /db_xref="EnsemblGenomes-Tr:CAB13035" /db_xref="GOA:Q08309" /db_xref="InterPro:IPR011428" /db_xref="SubtiList:BG10496" /db_xref="UniProtKB/Swiss-Prot:Q08309" /translation="MSFEEKVESLHPAIFEQLSSEFEQQIEVIDCENITIDTSHITAA LSIQAFVTTMIIVATQLVIADEDLADAVASEILILDSSQIKKRTIIKIINSRNIKITL SADEIITFVQILLQVLNSILSELDVL*" /label="cotV CDS" gene complement(1201202..1201588) /gene="cotV" /locus_tag="BSU_11780" /old_locus_tag="BSU11780" /label="cotV gene" promotor_-35 1201584..1201588 /Source="Nicolas_upshift_promotors" /id="U951" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.99100899100899" /psig="0.005994005994006" /xcortree=1245 /SigmaFactorBS="ttgctcaaatattgcagggtgcagggattcgactttttcttc aaatGACATaaccttcACTCCTTTCTTATCCatactctatataatgcaaatggggtgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1201596..1201610 /Source="Nicolas_upshift_promotors" /id="U951" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.99100899100899" /psig="0.005994005994006" /xcortree=1245 /SigmaFactorBS="ttgctcaaatattgcagggtgcagggattcgactttttcttc aaatGACATaaccttcACTCCTTTCTTATCCatactctatataatgcaaatggggtgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1201598 /Source="Nicolas_upshifts" /id="U951" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.99100899100899" /psig="0.005994005994006" /xcortree=1245 /SigmaFactorBS="ttgctcaaatattgcagggtgcagggattcgactttttcttc aaatGACATaaccttcACTCCTTTCTTATCCatactctatataatgcaaatggggtgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1201608..1201627) /Source="Nicolas_upshift_promotors" /id="U952" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.748251748251748" /psig="0.748251748251748" /xcortree=1351 /SigmaFactorBS="catgaattgtatcttgtccggcagaaaattggttatttttat taTtCcGctctgcaccccattTGCATTATATAGAGTATGGAtaagaaaggagtgaagg t" /listShort="cotV, cotW, S421, cotX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1201630) /Source="Nicolas_upshifts" /id="U952" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.748251748251748" /psig="0.748251748251748" /xcortree=1351 /SigmaFactorBS="catgaattgtatcttgtccggcagaaaattggttatttttat taTtCcGctctgcaccccattTGCATTATATAGAGTATGGAtaagaaaggagtgaagg t" /listShort="cotV, cotW, S421, cotX" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1201632..1202136) /Source="Nicolas_S_feature" /locus_tag="new_1252061_1252565_c" /HighExp="S8, S6, S7, BT, S5, B36, Pyr, C30, G/S, nit" /AntisenseName="yjcA" /AntisenseCor="0.69838474492609404" /AntisenseRegPval="-39.9" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.98" /TUlongSig="NA" /TUlongPSig="NA" /label="S422" promotor_-35 1201685..1201690 /Source="Nicolas_upshift_promotors" /id="U953" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1132 /SigmaFactorBS="aataaaaataaccaattttctgccggacaagatacaaTTCAT GaagaatagggttttgGCATATATGTGAAGGGATCatgattggcaaaggagtgaacga g" /listShort="yjcA, S423" /listLong="yjzK, yjcZ, S424, spoVIF, S425" /label="promotor_-35" promotor_-10 1201706..1201724 /Source="Nicolas_upshift_promotors" /id="U953" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1132 /SigmaFactorBS="aataaaaataaccaattttctgccggacaagatacaaTTCAT GaagaatagggttttgGCATATATGTGAAGGGATCatgattggcaaaggagtgaacga g" /listShort="yjcA, S423" /listLong="yjzK, yjcZ, S424, spoVIF, S425" /label="promotor_-10" upshifts 1201708 /Source="Nicolas_upshifts" /id="U953" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1132 /SigmaFactorBS="aataaaaataaccaattttctgccggacaagatacaaTTCAT GaagaatagggttttgGCATATATGTGAAGGGATCatgattggcaaaggagtgaacga g" /listShort="yjcA, S423" /listLong="yjzK, yjcZ, S424, spoVIF, S425" /label="upshifts" CDS 1201748..1202104 /gene="yjcA" /locus_tag="BSU_11790" /old_locus_tag="BSU11790" /function="16.8: Protect" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:14523132, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14523132, 15849754, 16850406; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="sporulation-specific protein" /protein_id="NP_389061.1" /db_xref="EnsemblGenomes-Gn:BSU11790" /db_xref="EnsemblGenomes-Tr:CAB13036" /db_xref="GOA:O31623" /db_xref="InterPro:IPR010773" /db_xref="SubtiList:BG13154" /db_xref="UniProtKB/Swiss-Prot:O31623" /translation="MVINGLTIVLLSLAVFRLARLLVFDTIMAPLRSLFHEEKEEKDA DGNIETYIVIKGTGVRAFIGELLSCYWCTGVWCAGFLILCQAVIPQAAQWLILLLAIA GLAGIIETLVSKWLQE*" /label="yjcA CDS" gene 1201748..1202104 /gene="yjcA" /locus_tag="BSU_11790" /old_locus_tag="BSU11790" /label="yjcA gene" promotor_-35 1202114..1202123 /Source="Nicolas_upshift_promotors" /id="U955" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1353 /SigmaFactorBS="gctcgtatcaaaatggctgcaagaataaggcgttaccACCAG CAACTttctgtcagaataCGCATAAAGTAGCATATAtgacataaggaaaggaagggga c" /listShort="S423, yjzK" /listLong="yjcZ, S424, spoVIF, S425" /label="promotor_-35" promotor_-10 complement(1202121..1202140) /Source="Nicolas_upshift_promotors" /id="U954" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=1256 /SigmaFactorBS="atgatgctgattcatttttgtccccttcctttcCTTATGTCA TatatgctactttaTGCGTATTCTGACAGAAAGTtgctggtggtaacgccttattctt g" /listShort="S422" /listLong="cotV, cotW, S421, cotX" /label="promotor_-10" CDS complement(1202129..1202362) /locus_tag="BSU_11798" /old_locus_tag="BSU11798" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="protein remnant" /db_xref="PSEUDO:SOX90549.1" /translation="MLSETASLKKQKTGVLRFLCQAIEAFSFYFRTRSLSFLSFLIDT MNLYMEIFGKVYDADSFLSPSFPYVIYATLCVF*" /label="protein remnant CDS" gene complement(1202129..1202362) /locus_tag="BSU_11798" /old_locus_tag="BSU11798" /pseudo /label="gene" upshifts complement(1202136) /Source="Nicolas_upshifts" /id="U954" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=1256 /SigmaFactorBS="atgatgctgattcatttttgtccccttcctttcCTTATGTCA TatatgctactttaTGCGTATTCTGACAGAAAGTtgctggtggtaacgccttattctt g" /listShort="S422" /listLong="cotV, cotW, S421, cotX" /label="upshifts" S_feature 1202137..1202323 /Source="Nicolas_S_feature" /locus_tag="new_1252566_1252752" /HighExp="S8, S6, S7, BT, S5, B36, S4, S3, G/S, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.26970100000000002" /TUshortSig="SigK, SigEF" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S423" promotor_-10 1202137..1202154 /Source="Nicolas_upshift_promotors" /id="U955" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1353 /SigmaFactorBS="gctcgtatcaaaatggctgcaagaataaggcgttaccACCAG CAACTttctgtcagaataCGCATAAAGTAGCATATAtgacataaggaaaggaagggga c" /listShort="S423, yjzK" /listLong="yjcZ, S424, spoVIF, S425" /label="promotor_-10" upshifts 1202137 /Source="Nicolas_upshifts" /id="U955" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1353 /SigmaFactorBS="gctcgtatcaaaatggctgcaagaataaggcgttaccACCAG CAACTttctgtcagaataCGCATAAAGTAGCATATAtgacataaggaaaggaagggga c" /listShort="S423, yjzK" /listLong="yjcZ, S424, spoVIF, S425" /label="upshifts" promotor_-35 complement(1202154..1202163) /Source="Nicolas_upshift_promotors" /id="U954" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=1256 /SigmaFactorBS="atgatgctgattcatttttgtccccttcctttcCTTATGTCA TatatgctactttaTGCGTATTCTGACAGAAAGTtgctggtggtaacgccttattctt g" /listShort="S422" /listLong="cotV, cotW, S421, cotX" /label="promotor_-35" downshifts complement(1202180) /Source="Nicolas_upshifts" /id="D643" /incds=0 /nref=2 /ntot=13 /MaxReadThrough="3.12564" /MaxDrop="4.58782" /score="-6.14331629" /energy="-6.8" /TU="NA" /idTUdmin="U954" /TUdmin="-528" /isTUend="FALSE" /label="downshifts" downshifts 1202280 /Source="Nicolas_upshifts" /id="D644" /incds=0 /nref=3 /ntot=32 /MaxReadThrough="5.73879" /MaxDrop="3.6919" /score="33.8150878" /energy="-6.8" /TU="U953,U955" /idTUdmin="U953" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" upshifts complement(1202334) /Source="Nicolas_upshifts" /id="U956" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.284715284715285" /psig="0.032967032967033" /xcortree=768 /SigmaFactorBS="ctcattcacttttatccccccgcttatgatatatgctgagcg agaCCGCCTCGttaaaaaaacaaaaaaccggagttctccggtttctttgccaggctat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1202335..1202344 /Source="Nicolas_upshift_promotors" /id="U957" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1288 /SigmaFactorBS="gaaaccggagaactccggttttttgttTTTTTAACGAggcgg tctcgctcAGCATATATCATAAGCGGGGggataaaagtgaatgagtttgaaaaatgga t" /listShort="yjzK, yjcZ, S424, spoVIF, S425" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(1202342..1202349) /Source="Nicolas_upshift_promotors" /id="U956" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.284715284715285" /psig="0.032967032967033" /xcortree=768 /SigmaFactorBS="ctcattcacttttatccccccgcttatgatatatgctgagcg agaCCGCCTCGttaaaaaaacaaaaaaccggagttctccggtttctttgccaggctat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 1202358..1202377 /Source="Nicolas_upshift_promotors" /id="U957" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1288 /SigmaFactorBS="gaaaccggagaactccggttttttgttTTTTTAACGAggcgg tctcgctcAGCATATATCATAAGCGGGGggataaaagtgaatgagtttgaaaaatgga t" /listShort="yjzK, yjcZ, S424, spoVIF, S425" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1202368 /Source="Nicolas_upshifts" /id="U957" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1288 /SigmaFactorBS="gaaaccggagaactccggttttttgttTTTTTAACGAggcgg tctcgctcAGCATATATCATAAGCGGGGggataaaagtgaatgagtttgaaaaatgga t" /listShort="yjzK, yjcZ, S424, spoVIF, S425" /GFF_Attribute="listLong" /label="upshifts" CDS 1202386..1202592 /gene="yjzK" /locus_tag="BSU_11799" /old_locus_tag="BSU11799" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097704.1" /db_xref="EnsemblGenomes-Gn:BSU11799" /db_xref="EnsemblGenomes-Tr:CAX52594" /db_xref="UniProtKB/Swiss-Prot:C0H3Y7" /translation="MNEFEKWIEGRYEPHEQKQKEHEDTMGSIRKDLDAFDKAGLEFE DEIEELAEKTEALLKKHQAQYDQS*" /label="yjzK CDS" gene 1202386..1202592 /gene="yjzK" /locus_tag="BSU_11799" /old_locus_tag="BSU11799" /label="yjzK gene" CDS 1202429..1202644 /gene="yjcB" /locus_tag="BSU_11800" /old_locus_tag="BSU11800" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:14523132" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14523132; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="sporulation-specific protein" /protein_id="YP_009513951.1" /translation="MNKSKKSMKTRWAVSEKTWMHLIKPVWNLKMRLKSWLKKRRPYL KNIKLNMINRKSANALCEYPSRSQQLT*" /label="yjcB CDS" gene 1202429..1202644 /gene="yjcB" /locus_tag="BSU_11800" /old_locus_tag="BSU11800" /label="yjcB gene" promotor_-35 1202616..1202625 /Source="Nicolas_upshift_promotors" /id="U958" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1409 /SigmaFactorBS="tcaatcgtaaatccgcaaacgccctatgcgaatATCCAAGCC GatcccagcagctCACATAGTGTATAGAGAGTAaaggaggtgcttatctatgggcttt g" /listShort="yjcZ, S424, spoVIF, S425" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1202638..1202657 /Source="Nicolas_upshift_promotors" /id="U958" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1409 /SigmaFactorBS="tcaatcgtaaatccgcaaacgccctatgcgaatATCCAAGCC GatcccagcagctCACATAGTGTATAGAGAGTAaaggaggtgcttatctatgggcttt g" /listShort="yjcZ, S424, spoVIF, S425" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1202643 /Source="Nicolas_upshifts" /id="U958" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1409 /SigmaFactorBS="tcaatcgtaaatccgcaaacgccctatgcgaatATCCAAGCC GatcccagcagctCACATAGTGTATAGAGAGTAaaggaggtgcttatctatgggcttt g" /listShort="yjcZ, S424, spoVIF, S425" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1202650..1202664) /Source="Nicolas_upshift_promotors" /id="U959" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=690 /SigmaFactorBS="gccataacagccgccgccgtagccgccgccgaatccgtatcc aaagCCCATagataagcaCCTCCTTTACTCTCTatacactatgtgagctgctgggatc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1202664) /Source="Nicolas_upshifts" /id="U959" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=690 /SigmaFactorBS="gccataacagccgccgccgtagccgccgccgaatccgtatcc aaagCCCATagataagcaCCTCCTTTACTCTCTatacactatgtgagctgctgggatc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1202674..1202678) /Source="Nicolas_upshift_promotors" /id="U959" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=690 /SigmaFactorBS="gccataacagccgccgccgtagccgccgccgaatccgtatcc aaagCCCATagataagcaCCTCCTTTACTCTCTatacactatgtgagctgctgggatc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1202674..1202823 /gene="yjcZ" /locus_tag="BSU_11809" /old_locus_tag="BSU11809" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14523132, 20156992, 21670523; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative type I toxin" /protein_id="YP_003097705.1" /db_xref="EnsemblGenomes-Gn:BSU11809" /db_xref="EnsemblGenomes-Tr:CAX52595" /db_xref="GOA:C0H3Y8" /db_xref="InterPro:IPR010070" /db_xref="UniProtKB/Swiss-Prot:C0H3Y8" /translation="MGFGYGFGGGYGGGCYGGYAGGYGGGYGSTFVLLVVLFILLIIV GASFF*" /label="yjcZ CDS" gene 1202674..1202823 /gene="yjcZ" /locus_tag="BSU_11809" /old_locus_tag="BSU11809" /label="yjcZ gene" downshifts 1202764 /Source="Nicolas_upshifts" /id="D645" /incds=0 /nref=4 /ntot=29 /MaxReadThrough="8.16203" /MaxDrop="4.48861" /score="1.53429015" /energy="-22.4" /TU="U957,U958" /idTUdmin="U955" /TUdmin=110 /isTUend="FALSE" /label="downshifts" S_feature 1202824..1202955 /Source="Nicolas_S_feature" /locus_tag="new_1253253_1253384" /HighExp="S7, BT, S8, B36, S6, G/S, Pyr, B60, S5, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigK" /TUshortPSig="1, 0.971" /TUlongSig="SigK, SigEF" /TUlongPSig="0.999, 1" /label="S424" CDS 1202956..1203210 /gene="spoVIF" /locus_tag="BSU_11810" /old_locus_tag="BSU11810" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:14523132, 14702409, 20435725" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14523132, 14702409, 20435725; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="sporulation-specific protein needed for heat resistance" /protein_id="NP_389063.2" /db_xref="EnsemblGenomes-Gn:BSU11810" /db_xref="EnsemblGenomes-Tr:CAB13038" /db_xref="GOA:O31625" /db_xref="InterPro:IPR025942" /db_xref="SubtiList:BG13156" /db_xref="UniProtKB/Swiss-Prot:O31625" /translation="MDNQFFKNIEKKTGVKMQDVMNLAGSLQNANFKDENTVRSVINR VAQMANRRVPKELEDKIVESITSGKEKLDFGTISKMMDNK*" /label="spoVIF CDS" gene 1202956..1203210 /gene="spoVIF" /locus_tag="BSU_11810" /old_locus_tag="BSU11810" /label="spoVIF gene" downshifts 1203195 /Source="Nicolas_upshifts" /id="D646" /incds=0 /nref=40 /ntot=79 /MaxReadThrough="5.66609" /MaxDrop="5.8411" /score="7.68851688" /energy="-10.7" /TU="U957,U958" /idTUdmin="U955" /TUdmin=541 /isTUend="FALSE" /label="downshifts" downshifts complement(1203214) /Source="Nicolas_upshifts" /id="D647" /incds=0 /nref=3 /ntot=9 /MaxReadThrough="3.12148" /MaxDrop="4.34051" /score="24.4726468" /energy="-14.3" /TU="NA" /idTUdmin="U961" /TUdmin=88 /isTUend="FALSE" /label="downshifts" S_feature 1203240..1204340 /Source="Nicolas_S_feature" /locus_tag="new_1253669_1254769" /HighExp="S8, S6, S7, B36, S5, C30, BT, dia15, Diami, H2O2" /AntisenseName="yjcD" /AntisenseCor="-0.210610370451118" /AntisenseRegPval="-3.3" /CDS_PredictionProba="0.18426200000000001" /TUshortSig="SigK, SigK" /TUshortPSig="1, 0.971" /TUlongSig="SigK, SigEF" /TUlongPSig="0.999, 1" /label="S425" CDS complement(1203284..1205563) /gene="yjcD" /locus_tag="BSU_11820" /old_locus_tag="BSU11820" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11544244, 16014871, 17114254, 22933559; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ATP-dependent DNA helicase (sporulationassociated)" /protein_id="NP_389064.3" /db_xref="EnsemblGenomes-Gn:BSU11820" /db_xref="EnsemblGenomes-Tr:CAB13039" /db_xref="GOA:O31626" /db_xref="InterPro:IPR000212" /db_xref="InterPro:IPR014016" /db_xref="InterPro:IPR014017" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR034739" /db_xref="SubtiList:BG13157" /db_xref="UniProtKB/Swiss-Prot:O31626" /translation="MKCARLNDRIIHLHTYSREHYQFLFEEGIKGHLFCSHCGKPVLL RLNIADPPEFIHRQPGDFPACEEACEPKPSKEGKKEDDQESGVIRLPKGKAIAADPSP AVTEWHRPRSIKPGTPFVPKTIEPDTSLFPSVGLNTDQLKAVTETEGPLLVLAGAGSG KTRVLTARAAHMIEHLGIPPENMLLVTFTTKAVAEMKERMANQYGLQPAKVRRIVTGT FHSLFYKILYHSNSAKWNGEHLLKMEWQREQYIKKALYEEGIDEKESPVDQALQQIGF WKNTYVPNERIPLKDEWEKQVYRLYEHYERQKKEHSQFDFDDMASACYELFIERPDLL EQYQSRFTYILIDEFQDINPVQYKIMQMLASPEQNLCCVGDDDQSIYAFRGSNPSFIL DFQKDYPGAKTIYLTANYRSTHPIVSSADIVVKKNKNRYAKTLEAARDDIQVPVLFYP YDEEEEATMVVSDIKEKIQNGASPEDFAVLYRTNSGGRAIYERLHQSSIPYTADRGVQ SFYSRRIVRQILAYLYASQNEDDTEAIKHLLPALFLKQSALNTLKALSITEDCTMIKA LAKLPDLKPFQLDKIKKIVPFFASLRTMKPVEAITFAEGKMGFSEYLKKRGNEGNKLE KGSDDLRDIKVVAKKFKTIPDFLAHVDHMRAAEKNRTDEHGVQLMTIHRSKGLEFKTV YVLGTVDGSIPHDFSLETARKGDEAALEEERRLLYVAMTRAKQHLYLSCPANRRGKTA NRSRFLYPLLQKARQPLHH*" /label="yjcD CDS" gene complement(1203284..1205563) /gene="yjcD" /locus_tag="BSU_11820" /old_locus_tag="BSU11820" /label="yjcD gene" downshifts complement(1203302) /Source="Nicolas_upshifts" /id="D648" /incds=0 /nref=61 /ntot=171 /MaxReadThrough="2.59869" /MaxDrop="4.36061" /score="24.4726468" /energy="-14.3" /TU="NA" /idTUdmin="U961" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1205438..1205612) /Source="Nicolas_S_feature" /locus_tag="new_1255867_1256041_c" /HighExp="G180, G135, G150, H2O2, Paraq, Oxctl, LBGexp, dia15, dia0, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S426" promotor_-35 1205491..1205499 /Source="Nicolas_upshift_promotors" /id="U960" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.868131868131868" /psig="0.868131868131868" /xcortree=958 /SigmaFactorBS="tgagaacaaaataaatgtccttttattccctcttcaaAGAGG AATTgataatgttcTCTCGAATATGTATGTAAAtgtatgattctatcattcagtcggg c" /listShort="S427, yjzE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1205510..1205528 /Source="Nicolas_upshift_promotors" /id="U960" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.868131868131868" /psig="0.868131868131868" /xcortree=958 /SigmaFactorBS="tgagaacaaaataaatgtccttttattccctcttcaaAGAGG AATTgataatgttcTCTCGAATATGTATGTAAAtgtatgattctatcattcagtcggg c" /listShort="S427, yjzE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1205514..1205649 /Source="Nicolas_S_feature" /locus_tag="new_1255943_1256078" /HighExp="S4, S5, S3, S6, S7, S8, M9-stat, T4.0H, T3.0H, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH" /TUshortPSig="0.868" /TUlongSig="NA" /TUlongPSig="NA" /label="S427" upshifts 1205514 /Source="Nicolas_upshifts" /id="U960" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.868131868131868" /psig="0.868131868131868" /xcortree=958 /SigmaFactorBS="tgagaacaaaataaatgtccttttattccctcttcaaAGAGG AATTgataatgttcTCTCGAATATGTATGTAAAtgtatgattctatcattcagtcggg c" /listShort="S427, yjzE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1205600..1205619) /Source="Nicolas_upshift_promotors" /id="U961" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2545 /SigmaFactorBS="cacccctctgctgtctcttttcccttaaacttACTTTttgaa acacatttctTTTGATATGATAGTCATTGTctgtaatgaacaccttttgattgggagg a" /listShort="S426, yjcD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1205611) /Source="Nicolas_upshifts" /id="U961" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2545 /SigmaFactorBS="cacccctctgctgtctcttttcccttaaacttACTTTttgaa acacatttctTTTGATATGATAGTCATTGTctgtaatgaacaccttttgattgggagg a" /listShort="S426, yjcD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1205627..1205633 /Source="Nicolas_upshift_promotors" /id="U962" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=197 /SigmaFactorBS="tcattacagacaatgactatcatatcaaaagaaatgTGTTTC AaaaagtaagtttaaGGGAAAAGAGACAGCAGAGgggtgggtattgtatgatatatgc a" /listShort="yjzE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(1205635..1205639) /Source="Nicolas_upshift_promotors" /id="U961" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2545 /SigmaFactorBS="cacccctctgctgtctcttttcccttaaacttACTTTttgaa acacatttctTTTGATATGATAGTCATTGTctgtaatgaacaccttttgattgggagg a" /listShort="S426, yjcD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1205648..1205666 /Source="Nicolas_upshift_promotors" /id="U962" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=197 /SigmaFactorBS="tcattacagacaatgactatcatatcaaaagaaatgTGTTTC AaaaagtaagtttaaGGGAAAAGAGACAGCAGAGgggtgggtattgtatgatatatgc a" /listShort="yjzE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1205651 /Source="Nicolas_upshifts" /id="U962" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=197 /SigmaFactorBS="tcattacagacaatgactatcatatcaaaagaaatgTGTTTC AaaaagtaagtttaaGGGAAAAGAGACAGCAGAGgggtgggtattgtatgatatatgc a" /listShort="yjzE" /GFF_Attribute="listLong" /label="upshifts" CDS 1205680..1205934 /gene="yjzE" /locus_tag="BSU_11839" /old_locus_tag="BSU11839" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 11976315, 23155385" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097706.1" /db_xref="EnsemblGenomes-Gn:BSU11839" /db_xref="EnsemblGenomes-Tr:CAX52596" /db_xref="UniProtKB/Swiss-Prot:C0H3Y9" /translation="MIYAGQIQNQQYAQYANRTIGHKQDYAGTEKISYVPFQRVYKEL EKQQENQTAAERKVNEMKRKRSLYKRLREKGMGTYINRYV*" /label="yjzE CDS" gene 1205680..1205934 /gene="yjzE" /locus_tag="BSU_11839" /old_locus_tag="BSU11839" /label="yjzE gene" downshifts 1205910 /Source="Nicolas_upshifts" /id="D649" /incds=0 /nref=101 /ntot=248 /MaxReadThrough="3.69482" /MaxDrop="7.80206" /score="5.37568515" /energy="-6.1" /TU="U962" /idTUdmin="U960" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1206000) /Source="Nicolas_upshifts" /id="D650" /incds=0 /nref=78 /ntot=283 /MaxReadThrough="3.21062" /MaxDrop="7.8562" /score="-4.05705392" /energy="-6.1" /TU="U963" /idTUdmin="U963" /TUdmin="-36" /isTUend="FALSE" /label="downshifts" CDS complement(1206007..1206429) /gene="yjcF" /locus_tag="BSU_11840" /old_locus_tag="BSU11840" /EC_number="2.3.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_389066.1" /db_xref="EnsemblGenomes-Gn:BSU11840" /db_xref="EnsemblGenomes-Tr:CAB13041" /db_xref="GOA:O31628" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="PDB:1Q2Y" /db_xref="SubtiList:BG13159" /db_xref="UniProtKB/Swiss-Prot:O31628" /translation="MKAVIAKNEEQLKDAFYVREEVFVKEQNVPAEEEIDELENESEH IVVYDGEKPVGAGRWRMKDGYGKLERICVLKSHRSAGVGGIIMKALEKAAADGGASGF ILNAQTQAVPFYKKHGYRVLSEKEFLDAGIPHLQMMKD*" /label="yjcF CDS" gene complement(1206007..1206429) /gene="yjcF" /locus_tag="BSU_11840" /old_locus_tag="BSU11840" /label="yjcF gene" CDS complement(1206433..1206948) /gene="yjcG" /locus_tag="BSU_11850" /old_locus_tag="BSU11850" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12466548, 16511078, 17012785, 18473364, 25643072; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA ligase or phosphoesterase" /protein_id="NP_389067.1" /db_xref="EnsemblGenomes-Gn:BSU11850" /db_xref="EnsemblGenomes-Tr:CAB13042" /db_xref="GOA:O31629" /db_xref="InterPro:IPR009097" /db_xref="InterPro:IPR022932" /db_xref="PDB:2D4G" /db_xref="SubtiList:BG13160" /db_xref="UniProtKB/Swiss-Prot:O31629" /translation="MKYGIVLFPSKKLQDLANSYRKRYDPSYSLIPPHLTLRASFECA EEKADQLVSHLRNIAKESHPLVLKMTKYSSFAPVNNVIYIKAEPTEELKTLNEKLYTG VLAGEQEYNFVPHVTVGQNLSDDEHSDVLGQLKMQEVSHEEIVDRFHLLYQLENGSWT VYETFLLGRGE*" /label="yjcG CDS" gene complement(1206433..1206948) /gene="yjcG" /locus_tag="BSU_11850" /old_locus_tag="BSU11850" /label="yjcG gene" CDS complement(1206985..1207707) /gene="yjcH" /locus_tag="BSU_11860" /old_locus_tag="BSU11860" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20941576; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative stress-related hydrolase" /protein_id="NP_389068.1" /db_xref="EnsemblGenomes-Gn:BSU11860" /db_xref="EnsemblGenomes-Tr:CAB13043" /db_xref="InterPro:IPR000801" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG13161" /db_xref="UniProtKB/Swiss-Prot:O31630" /translation="MAPKNGTVQEKKFFSKELNEEMTLLVYLPSNYSPLYKYHVIIAQ DGHDYFRLGRIGRQVEELLSKREIDRSIIIGVPYKDVKERRNTYHPEGSKFSAYKRFI AHELVPFADDEYPTYQIGYGRTLIGDSLGATVSLMTALDYPNMFGNIIMQSPYVDKHV LEAVKQSDDIKHLSIYHQIGTKETDVHTTDGNILDFTEPNRELKQLLEKKLSDYDFEP FDGDHKWTYWQPLITPALKKML*" /label="yjcH CDS" gene complement(1206985..1207707) /gene="yjcH" /locus_tag="BSU_11860" /old_locus_tag="BSU11860" /label="yjcH gene" misc_feature complement(1207746..1207765) /Source="Nicolas_upshift_promotors" /id="U963" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2938 /SigmaFactorBS="tttatttcaacacttttttcttcgtgtgccgaaccgtttaaa gagagaaatttctaataattCATGGTACAATAATTGAAAAtgcaagaaagtatagtga t" /listShort="yjcH, yjcG, yjcF" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1207767) /Source="Nicolas_upshifts" /id="U963" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2938 /SigmaFactorBS="tttatttcaacacttttttcttcgtgtgccgaaccgtttaaa gagagaaatttctaataattCATGGTACAATAATTGAAAAtgcaagaaagtatagtga t" /listShort="yjcH, yjcG, yjcF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1207816..1207823 /Source="Nicolas_upshift_promotors" /id="U964" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2887 /SigmaFactorBS="tctctttaaacggttcggcacacgaagaaaaaagTGTTGAAA taaactgtgaattgCGCTAATATAAAACAATCAGaaaattgaaatcgatatttcttat c" /listShort="NA, metI, metC, S428" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1207838..1207857 /Source="Nicolas_upshift_promotors" /id="U964" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2887 /SigmaFactorBS="tctctttaaacggttcggcacacgaagaaaaaagTGTTGAAA taaactgtgaattgCGCTAATATAAAACAATCAGaaaattgaaatcgatatttcttat c" /listShort="NA, metI, metC, S428" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1207842 /Source="Nicolas_upshifts" /id="U964" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2887 /SigmaFactorBS="tctctttaaacggttcggcacacgaagaaaaaagTGTTGAAA taaactgtgaattgCGCTAATATAAAACAATCAGaaaattgaaatcgatatttcttat c" /listShort="NA, metI, metC, S428" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 1207875..1207995 /gene="mswA" /locus_tag="BSU_misc_RNA_15" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762; Product type n: RNA" /function="16.3: Control" /label="mswA RNA" gene 1207875..1207995 /gene="mswA" /locus_tag="BSU_misc_RNA_15" /label="mswA gene" downshifts 1208000 /Source="Nicolas_upshifts" /id="D651" /incds=0 /nref=8 /ntot=59 /MaxReadThrough="7.71668" /MaxDrop="5.0477" /score="31.1477774" /energy="-15.2" /TU="U964" /idTUdmin="U962" /TUdmin=2024 /isTUend="FALSE" /label="downshifts" CDS 1208063..1209184 /gene="metI" /locus_tag="BSU_11870" /old_locus_tag="BSU11870" /EC_number="2.5.1.49" /EC_number="2.5.1.48" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 11832514, 22938038" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11832514, 22938038; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cystathionine gamma-synthase and O-acetylhomoserine thiolyase" /protein_id="NP_389069.1" /db_xref="EnsemblGenomes-Gn:BSU11870" /db_xref="EnsemblGenomes-Tr:CAB13044" /db_xref="GOA:O31631" /db_xref="InterPro:IPR000277" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG13162" /db_xref="UniProtKB/Swiss-Prot:O31631" /translation="MSQHVETKLAQIGNRSDEVTGTVSAPIYLSTAYRHRGIGESTGF DYVRTKNPTRQLVEDAIANLENGARGLAFSSGMAAIQTIMALFKSGDELIVSSDLYGG TYRLFENEWKKYGLTFHYDDFSDEDCLRSKITPNTKAVFVETPTNPLMQEADIEHIAR ITKEHGLLLIVDNTFYTPVLQRPLELGADIVIHSATKYLGGHNDLLAGLVVVKDERLG EEMFQHQNAIGAVLPPFDSWLLMRGMKTLSLRMRQHQANAQELAAFLEEQEEISDVLY PGKGGMLSFRLQKEEWVNPFLKALKTICFAESLGGVESFITYPATQTHMDIPEEIRIA NGVCNRLLRFSVGIEHAEDLKEDLKQALCQVKEGAVSFE*" /label="metI CDS" gene 1208063..1209184 /gene="metI" /locus_tag="BSU_11870" /old_locus_tag="BSU11870" /label="metI gene" CDS 1209177..1210349 /gene="metC" /locus_tag="BSU_11880" /old_locus_tag="BSU11880" /EC_number="4.4.1.8" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 11832514, 11948165, 15760717" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11832514, 11948165, 15760717; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cystathionine beta-lyase" /protein_id="NP_389070.1" /db_xref="EnsemblGenomes-Gn:BSU11880" /db_xref="EnsemblGenomes-Tr:CAB13045" /db_xref="GOA:O31632" /db_xref="InterPro:IPR000277" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG13163" /db_xref="UniProtKB/Swiss-Prot:O31632" /translation="MSKHNWTLETQLVHNPFKTDGGTGAVSVPIQHASTFHQSSFEEF GAYDYSRSGTPTRTALEETIAALEGGTRGFAFSSGMAAISTAFLLLSQGDHVLVTEDV YGGTFRMVTEVLTRFGIEHTFVDMTDRNEVARSIKPNTKVIYMETPSNPTLGITDIKA VVQLAKENGCLTFLDNTFMTPALQRPLDLGVDIVLHSATKFLSGHSDVLSGLAAVKDE ELGKQLYKLQNAFGAVLGVQDCWLVLRGLKTLQVRLEKASQTAQRLAEFFQKHPAVKR VYYPGLADHPGAETHKSQSTGAGAVLSFELESKEAVKKLVENVSLPVFAVSLGAVESI LSYPATMSHAAMPKEEREKRGITDGLLRLSVGVEHADDLEHDFEQALKEIAPVSVR*" /label="metC CDS" gene 1209177..1210349 /gene="metC" /locus_tag="BSU_11880" /old_locus_tag="BSU11880" /label="metC gene" downshifts 1210332 /Source="Nicolas_upshifts" /id="D652" /incds=0 /nref=108 /ntot=205 /MaxReadThrough="4.73188" /MaxDrop="5.54268" /score="4.00424187" /energy="-9.2" /TU="U964" /idTUdmin="U964" /TUdmin="-1474" /isTUend="FALSE" /label="downshifts" misc_feature 1210366..1210384 /Source="Nicolas_upshift_promotors" /id="U965" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.671328671328671" /psig="0.671328671328671" /xcortree=2911 /SigmaFactorBS="gctgaaagaaattgctccagtttcggttcgttaaaaaagaag ccggggatAGTCCGGCTTCTTTTATTAttgttcgtcatcaggattcagaatcgcgagg a" /listShort="S428" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1210376 /Source="Nicolas_upshifts" /id="U965" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.671328671328671" /psig="0.671328671328671" /xcortree=2911 /SigmaFactorBS="gctgaaagaaattgctccagtttcggttcgttaaaaaagaag ccggggatAGTCCGGCTTCTTTTATTAttgttcgtcatcaggattcagaatcgcgagg a" /listShort="S428" /GFF_Attribute="listLong" /label="upshifts" S_feature 1210377..1211906 /Source="Nicolas_S_feature" /locus_tag="new_1260806_1262335" /HighExp="MG 5, MG t5, MG 10, BMM, GM 25, MG 15, Glu, GM 15, GM 45, GM 10" /AntisenseName="yjcK" /AntisenseCor="0.123731990206979" /AntisenseRegPval="-1.4" /CDS_PredictionProba="NA" /TUshortSig="SigL, SigA" /TUshortPSig="0.671, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S428" CDS complement(1210382..1210927) /gene="yjcK" /locus_tag="BSU_11890" /old_locus_tag="BSU11890" /EC_number="2.3.1.267" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 2828880; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ribosomal-protein-alanine N-acetyltransferase" /protein_id="NP_389071.1" /db_xref="EnsemblGenomes-Gn:BSU11890" /db_xref="EnsemblGenomes-Tr:CAB13046" /db_xref="GOA:O31633" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13164" /db_xref="UniProtKB/Swiss-Prot:O31633" /translation="MLKGKTIYVRPLEVTDAEENLGLQSENRDFFEQFSMIRADDYYT VEGQRKRITEYQERLEKDEEYHFGIFTASDDRLIGTVSLFQIIRGALQTAFIGYFLDK AHNGKGIMTEAVRLVVDYAFHELKLHRIEAGVMPRNLGSMRVLEKAGFHKEGIARKNV KINGVWEDHQVLAILNPDDEQ*" /label="yjcK CDS" gene complement(1210382..1210927) /gene="yjcK" /locus_tag="BSU_11890" /old_locus_tag="BSU11890" /label="yjcK gene" downshifts complement(1210403) /Source="Nicolas_upshifts" /id="D653" /incds=0 /nref=14 /ntot=127 /MaxReadThrough="0.4032" /MaxDrop="4.23858" /score="-7.12102596" /energy="-7.3" /TU="NA" /idTUdmin="U966" /TUdmin="-17" /isTUend="TRUE" /label="downshifts" CDS complement(1210997..1212187) /gene="yjcL" /locus_tag="BSU_11900" /old_locus_tag="BSU11900" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein; possibly aquaporin-related" /protein_id="NP_389072.1" /db_xref="EnsemblGenomes-Gn:BSU11900" /db_xref="EnsemblGenomes-Tr:CAB13047" /db_xref="GOA:O31634" /db_xref="InterPro:IPR008537" /db_xref="SubtiList:BG13165" /db_xref="UniProtKB/Swiss-Prot:O31634" /translation="MHSLISSDDVWVLWGFIAVWAAVSIGLEQRFKWASAVSGAIIAL AGAMVFTNVGVLPVESPVYDTVWSYVVPLAIPLLLFQINVRQIFKESRRLLFIFLISS VGTVLGSILAFFLLKQHIPYLDKIGGMISASYIGGGVNFAAMAAKFETPGEYVSATVV ADNFMMALLFFILISIPALKWFQRHYAMPFEEKVKADGNSGNSAESYWKRKDISLKDI AFNAGAAFALVAVSMKVSGYFKSIFSHPLLTGTLGDQYLVLTSLTVLIIFLFPRFFER LNGSQELGTFLIYLFFVVIGIPADLRLIVTNAPLILLFVFIIAISNLAVSLAAGKLFR VRLEEILLAVNATVGGPTTAAAMAIAKGWRELVAPIMLVGTLGYLIGNYVGTFMGNWF SSFL*" /label="yjcL CDS" gene complement(1210997..1212187) /gene="yjcL" /locus_tag="BSU_11900" /old_locus_tag="BSU11900" /label="yjcL gene" promotor_-10 complement(1212213..1212232) /Source="Nicolas_upshift_promotors" /id="U966" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.448551448551449" /psig=1 /xcortree=2871 /SigmaFactorBS="ttttttagaaaaactttttttggACTTGCTGttccgttcccc ggcTATTATAATATGTCTTAATTttctaacaatagaggtgatggggttttgcattctt t" /listShort="yjcL, yjcK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1212217) /Source="Nicolas_upshifts" /id="U966" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.448551448551449" /psig=1 /xcortree=2871 /SigmaFactorBS="ttttttagaaaaactttttttggACTTGCTGttccgttcccc ggcTATTATAATATGTCTTAATTttctaacaatagaggtgatggggttttgcattctt t" /listShort="yjcL, yjcK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1212247..1212254) /Source="Nicolas_upshift_promotors" /id="U966" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.448551448551449" /psig=1 /xcortree=2871 /SigmaFactorBS="ttttttagaaaaactttttttggACTTGCTGttccgttcccc ggcTATTATAATATGTCTTAATTttctaacaatagaggtgatggggttttgcattctt t" /listShort="yjcL, yjcK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1212281..1212288 /Source="Nicolas_upshift_promotors" /id="U967" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.85914085914086" /psig=1 /xcortree=2414 /SigmaFactorBS="agccggggaacggaacagcaagtccaaaaaaagtttttctaa aaaagcaGTTGACGAatagaaggtaaggTTATATAATAGAACTTGTCAgaaagataac a" /listShort="trnSL-Val2, S430" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1212292 /Source="Nicolas_upshifts" /id="U967" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.85914085914086" /psig=1 /xcortree=2414 /SigmaFactorBS="agccggggaacggaacagcaagtccaaaaaaagtttttctaa aaaagcaGTTGACGAatagaaggtaaggTTATATAATAGAACTTGTCAgaaagataac a" /listShort="trnSL-Val2, S430" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1212302..1212321 /Source="Nicolas_upshift_promotors" /id="U967" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.85914085914086" /psig=1 /xcortree=2414 /SigmaFactorBS="agccggggaacggaacagcaagtccaaaaaaagtttttctaa aaaagcaGTTGACGAatagaaggtaaggTTATATAATAGAACTTGTCAgaaagataac a" /listShort="trnSL-Val2, S430" /GFF_Attribute="listLong" /label="promotor_-10" tRNA 1212360..1212432 /gene="trnSL-Val2" /locus_tag="BSU_tRNA_83" /product="tRNA-Val" /inference="profile:tRNAscan:1.23" /note="valine tRNA (GAC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Val2 tRNA" gene 1212360..1212432 /gene="trnSL-Val2" /locus_tag="BSU_tRNA_83" /label="trnSL-Val2 gene" promotor_-10 complement(1212374..1212391) /Source="Nicolas_upshift_promotors" /id="U968" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.926073926073926" /psig="0.007992007992008" /xcortree=394 /SigmaFactorBS="gcaagggtttaagctatgattccgactgggCTCGAACcagcg acctctaccctgtcaAGGTAGCGCTCTCCCAGCtgagctacggaatcatgatatgtat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1212388) /Source="Nicolas_upshifts" /id="U968" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.926073926073926" /psig="0.007992007992008" /xcortree=394 /SigmaFactorBS="gcaagggtttaagctatgattccgactgggCTCGAACcagcg acctctaccctgtcaAGGTAGCGCTCTCCCAGCtgagctacggaatcatgatatgtat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1212412..1212418) /Source="Nicolas_upshift_promotors" /id="U968" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.926073926073926" /psig="0.007992007992008" /xcortree=394 /SigmaFactorBS="gcaagggtttaagctatgattccgactgggCTCGAACcagcg acctctaccctgtcaAGGTAGCGCTCTCCCAGCtgagctacggaatcatgatatgtat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1212422 /Source="Nicolas_upshifts" /id="D654" /incds=0 /nref=17 /ntot=80 /MaxReadThrough="4.64061" /MaxDrop="5.10012" /score="20.8247903" /energy="-9.1" /TU="U967" /idTUdmin="U965" /TUdmin=550 /isTUend="FALSE" /label="downshifts" S_feature complement(1212447..1213182) /Source="Nicolas_S_feature" /locus_tag="new_1262876_1263611_c" /HighExp="M9-stat, Lbstat, M0t90, Pyr, T0.30H, M40t90, C30, S1, LPhT, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S429" S_feature 1212467..1214115 /Source="Nicolas_S_feature" /locus_tag="new_1262896_1264544" /HighExp="Cold, C30, G135, G180, G150, Oxctl, Fru, HPh, Glu, UNK1" /AntisenseName="yjcM" /AntisenseCor="0.46809452811910301" /AntisenseRegPval="-15.3" /CDS_PredictionProba="0.27514300000000003" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S430" downshifts complement(1212476) /Source="Nicolas_upshifts" /id="D655" /incds=0 /nref=29 /ntot=192 /MaxReadThrough="1.23936" /MaxDrop="3.57085" /score="-4.98447688" /energy="-7.9" /TU="NA" /idTUdmin="U970" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1213184..1213272) /Source="Nicolas_S_feature" /locus_tag="new_1263613_1263701_c" /HighExp="aero, HPh, M0t45, SMM, dia0, GM 150, Mal, M/G, Mt0, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S431" downshifts complement(1213227) /Source="Nicolas_upshifts" /id="D656" /incds=0 /nref=34 /ntot=148 /MaxReadThrough="4.13737" /MaxDrop="4.5557" /score="11.73443" /energy="-14.2" /TU="U970" /idTUdmin="U970" /TUdmin="-751" /isTUend="FALSE" /label="downshifts" CDS complement(1213273..1214502) /gene="yjcM" /locus_tag="BSU_11910" /old_locus_tag="BSU11910" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 20011599" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; phage island" /protein_id="NP_389073.1" /db_xref="EnsemblGenomes-Gn:BSU11910" /db_xref="EnsemblGenomes-Tr:CAB13048" /db_xref="InterPro:IPR024301" /db_xref="SubtiList:BG13166" /db_xref="UniProtKB/Swiss-Prot:O31635" /translation="MKKELLASLVLCLSLSPLVSTNEVFAATTNKETKENVSITNEIG YEKVKDMLEQQKYDFEHNTPLAHPKESKLTDSDEGVLLYSALSKVDKQKFHEFTYDID DVKTSEKNNKLIVEAYITRNFVFGVEKVTTSLGDNIKLEIPKTTSNKQSSQSTNTSNL SFSQVKNSSNQLNVIPLSNSSKQLNVTQLNNSSSTLQYENDEEYSSDVKLDEFLKKYK QEVKNDDKEEVKSEDKPVSMNFNAANSNQLTVTATSVKGYSGYAAMKYAEKYALKPNK NYKYYKDKDCTNFVSQALRAGRMPYFKEWKPYTDAWVNAGAFRSYILKAGGIKMKTVS DTYSNVKLGDVYHYDYHNKIGLRYADGWMDHTAIVTSRANMKLYVSYHSTNRLNVPRE YVTSKEGGKRYVSSIRN*" /label="yjcM CDS" gene complement(1213273..1214502) /gene="yjcM" /locus_tag="BSU_11910" /old_locus_tag="BSU11910" /label="yjcM gene" downshifts complement(1213395) /Source="Nicolas_upshifts" /id="D657" /incds=1 /nref=4 /ntot=143 /MaxReadThrough="5.58558" /MaxDrop="3.45178" /score="11.73443" /energy="-14.2" /TU="U970" /idTUdmin="U970" /TUdmin="-919" /isTUend="FALSE" /label="downshifts" downshifts 1214072 /Source="Nicolas_upshifts" /id="D658" /incds=1 /nref=1 /ntot=48 /MaxReadThrough="3.19343" /MaxDrop="1.98614" /score="26.2462772" /energy="-24.7" /TU="NA" /idTUdmin="U967" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1214503..1214588) /Source="Nicolas_S_feature" /locus_tag="new_1264932_1265017_c" /HighExp="aero, SMM, T-3.40H, MG 150, Lbexp, SMMPr, GM 90, C90, nit, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S432" promotor_-35 1214543..1214550 /Source="Nicolas_upshift_promotors" /id="U969" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.97902097902098" /psig="0.998001998001998" /xcortree=2298 /SigmaFactorBS="aaatctaaatataagtaatatttatCATTTACAccaattgaa atatgGCATAAAATACATGTAATAAtataacataaaaataaatacataaaaaggtatc g" /listShort="yjcN, S433, yjzF, yjzG, yjcO, S434, yjcP, yjcQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1214565..1214584 /Source="Nicolas_upshift_promotors" /id="U969" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.97902097902098" /psig="0.998001998001998" /xcortree=2298 /SigmaFactorBS="aaatctaaatataagtaatatttatCATTTACAccaattgaa atatgGCATAAAATACATGTAATAAtataacataaaaataaatacataaaaaggtatc g" /listShort="yjcN, S433, yjzF, yjzG, yjcO, S434, yjcP, yjcQ" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1214574..1214593) /Source="Nicolas_upshift_promotors" /id="U970" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.320679320679321" /psig="0.999000999001" /xcortree=2299 /SigmaFactorBS="gtataattttagttttctttttcattttttcctccgatacCT TTTTAtgtatttattttTATGTTATATTATTACATGTattttatgccatatttcaatt g" /listShort="S432, yjcM, S431, S429" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1214578 /Source="Nicolas_upshifts" /id="U969" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.97902097902098" /psig="0.998001998001998" /xcortree=2298 /SigmaFactorBS="aaatctaaatataagtaatatttatCATTTACAccaattgaa atatgGCATAAAATACATGTAATAAtataacataaaaataaatacataaaaaggtatc g" /listShort="yjcN, S433, yjzF, yjzG, yjcO, S434, yjcP, yjcQ" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1214592) /Source="Nicolas_upshifts" /id="U970" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.320679320679321" /psig="0.999000999001" /xcortree=2299 /SigmaFactorBS="gtataattttagttttctttttcattttttcctccgatacCT TTTTAtgtatttattttTATGTTATATTATTACATGTattttatgccatatttcaatt g" /listShort="S432, yjcM, S431, S429" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1214606..1214612) /Source="Nicolas_upshift_promotors" /id="U970" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.320679320679321" /psig="0.999000999001" /xcortree=2299 /SigmaFactorBS="gtataattttagttttctttttcattttttcctccgatacCT TTTTAtgtatttattttTATGTTATATTATTACATGTattttatgccatatttcaatt g" /listShort="S432, yjcM, S431, S429" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1214628..1214948 /gene="yjcN" /locus_tag="BSU_11920" /old_locus_tag="BSU11920" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; phage island" /protein_id="NP_389074.1" /db_xref="EnsemblGenomes-Gn:BSU11920" /db_xref="EnsemblGenomes-Tr:CAB13049" /db_xref="SubtiList:BG13167" /db_xref="UniProtKB/Swiss-Prot:O31636" /translation="MKKKTKIILSLLAALIVILIVLPVLSPVVFTASSEKGAIRHEIY KRGYPYQSYFAVLQKREGDNESGNLYYVNWLDWKDETGQTPHLCYSKKSSDGEYEVSC GTGP*" /label="yjcN CDS" gene 1214628..1214948 /gene="yjcN" /locus_tag="BSU_11920" /old_locus_tag="BSU11920" /label="yjcN gene" downshifts 1214958 /Source="Nicolas_upshifts" /id="D659" /incds=0 /nref=57 /ntot=233 /MaxReadThrough="3.73892" /MaxDrop="4.41989" /score="26.2462772" /energy="-24.7" /TU="U969" /idTUdmin="U967" /TUdmin=886 /isTUend="FALSE" /label="downshifts" S_feature 1215003..1215100 /Source="Nicolas_S_feature" /locus_tag="new_1265432_1265529" /HighExp="LoTm, B60, Cold, B36, T3.30H, T3.0H, T4.0H, T2.0H, Sw, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S433" CDS 1215101..1215232 /gene="yjzF" /locus_tag="BSU_11928" /old_locus_tag="BSU11928" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097707.1" /db_xref="EnsemblGenomes-Gn:BSU11928" /db_xref="EnsemblGenomes-Tr:CAX52597" /db_xref="UniProtKB/Swiss-Prot:C0H3Z0" /translation="MKQSKKKPSQKQHERLDRFWQQMMNTNMQTLRRGKGGAYKRRK* " /label="yjzF CDS" gene 1215101..1215232 /gene="yjzF" /locus_tag="BSU_11928" /old_locus_tag="BSU11928" /label="yjzF gene" CDS 1215248..1215421 /gene="yjzG" /locus_tag="BSU_11929" /old_locus_tag="BSU11929" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097708.1" /db_xref="EnsemblGenomes-Gn:BSU11929" /db_xref="EnsemblGenomes-Tr:CAX52598" /db_xref="UniProtKB/Swiss-Prot:C0H3Z1" /translation="MMKNGFAYKNGKLVNIFCGKEELYNELKAFLVKTFSINVKEVSR PSIYRRTKSKQLE*" /label="yjzG CDS" gene 1215248..1215421 /gene="yjzG" /locus_tag="BSU_11929" /old_locus_tag="BSU11929" /label="yjzG gene" CDS 1215458..1215919 /gene="yjcO" /locus_tag="BSU_11930" /old_locus_tag="BSU11930" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative DNA binding protein; phage island" /protein_id="NP_389075.1" /db_xref="EnsemblGenomes-Gn:BSU11930" /db_xref="EnsemblGenomes-Tr:CAB13050" /db_xref="GOA:O31637" /db_xref="InterPro:IPR013324" /db_xref="SubtiList:BG13168" /db_xref="UniProtKB/Swiss-Prot:O31637" /translation="MTDQMIAWEIEEWIRDYKFMLREIKRLNRVLNKVDFISTKLTAT YGEEAGMPRGSAGVSQAELRQMDRRERRLHKYESIVHYLDNAMEHIEEEKHRIVYDCM MEGMSYTAIANHLDCSRDTIRKIKTAIIGNIVNKVKEANFLQYLNSFKSAV*" /label="yjcO CDS" gene 1215458..1215919 /gene="yjcO" /locus_tag="BSU_11930" /old_locus_tag="BSU11930" /label="yjcO gene" promotor_-35 1215890..1215897 /Source="Nicolas_upshift_promotors" /id="U971" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.992007992007992" /psig="0.997002997002997" /xcortree=2045 /SigmaFactorBS="aataaagtcaaagaagccaactttctgcaaTATTTGAAttcg tttaaatcggCGGTGTAAAATGGGGGGCAGgatcggcgcggcggattattcctgcgtc a" /listShort="S434" /listLong="yjcP, yjcQ" /label="promotor_-35" promotor_-10 1215912..1215931 /Source="Nicolas_upshift_promotors" /id="U971" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.992007992007992" /psig="0.997002997002997" /xcortree=2045 /SigmaFactorBS="aataaagtcaaagaagccaactttctgcaaTATTTGAAttcg tttaaatcggCGGTGTAAAATGGGGGGCAGgatcggcgcggcggattattcctgcgtc a" /listShort="S434" /listLong="yjcP, yjcQ" /label="promotor_-10" S_feature 1215920..1216160 /Source="Nicolas_S_feature" /locus_tag="new_1266349_1266589" /HighExp="LoTm, B60, Cold, B36, Diami, S8, dia15, C30, dia5, LPhT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.12525800000000001" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S434" upshifts 1215920 /Source="Nicolas_upshifts" /id="U971" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.992007992007992" /psig="0.997002997002997" /xcortree=2045 /SigmaFactorBS="aataaagtcaaagaagccaactttctgcaaTATTTGAAttcg tttaaatcggCGGTGTAAAATGGGGGGCAGgatcggcgcggcggattattcctgcgtc a" /listShort="S434" /listLong="yjcP, yjcQ" /label="upshifts" promotor_-35 1216133..1216140 /Source="Nicolas_upshift_promotors" /id="U972" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2836 /SigmaFactorBS="caacagattcgttcgacaaattttgcaaattGTTAATCGata acttttcattCCCGATATTAAAAATGGGAgtgaattgtaaaatgaaaaaacagaaaaa t" /listShort="yjcP, yjcQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1216154..1216172 /Source="Nicolas_upshift_promotors" /id="U972" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2836 /SigmaFactorBS="caacagattcgttcgacaaattttgcaaattGTTAATCGata acttttcattCCCGATATTAAAAATGGGAgtgaattgtaaaatgaaaaaacagaaaaa t" /listShort="yjcP, yjcQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1216162 /Source="Nicolas_upshifts" /id="U972" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2836 /SigmaFactorBS="caacagattcgttcgacaaattttgcaaattGTTAATCGata acttttcattCCCGATATTAAAAATGGGAgtgaattgtaaaatgaaaaaacagaaaaa t" /listShort="yjcP, yjcQ" /GFF_Attribute="listLong" /label="upshifts" CDS 1216185..1216688 /gene="yjcP" /locus_tag="BSU_11940" /old_locus_tag="BSU11940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15033535" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein: phage island" /protein_id="NP_389076.1" /db_xref="EnsemblGenomes-Gn:BSU11940" /db_xref="EnsemblGenomes-Tr:CAB13051" /db_xref="GOA:O31638" /db_xref="SubtiList:BG13169" /db_xref="UniProtKB/Swiss-Prot:O31638" /translation="MKKQKNNKKKNIEKRNIEKRNIEEKNNEDLEELENAIYTYHKKE LLAFFLEKTRIGHDKEEYKRFQSLLYKLDIECLEFAISRFSHIDIIHDHSKYVPAFIP LFAAYLTMFFNFYEKHWGALSFAAGTIAAIVWIIAVERKHRNQAISIMKIFEQVKERK VKDRSKD*" /label="yjcP CDS" gene 1216185..1216688 /gene="yjcP" /locus_tag="BSU_11940" /old_locus_tag="BSU11940" /label="yjcP gene" CDS 1216700..1216984 /gene="yjcQ" /locus_tag="BSU_11950" /old_locus_tag="BSU11950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15033535" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; phage island" /protein_id="NP_389077.1" /db_xref="EnsemblGenomes-Gn:BSU11950" /db_xref="EnsemblGenomes-Tr:CAB13052" /db_xref="InterPro:IPR018597" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2HGC" /db_xref="SubtiList:BG13170" /db_xref="UniProtKB/Swiss-Prot:O31639" /translation="MNKDKLRYAILKEIFEGNTPLSENDIGVTEDQFDDAVNFLKREG YIIGVHYSDDRPHLYKLGPELTEKGENYLKENGTWSKAYKTIKEIKDWIK*" /label="yjcQ CDS" gene 1216700..1216984 /gene="yjcQ" /locus_tag="BSU_11950" /old_locus_tag="BSU11950" /label="yjcQ gene" downshifts 1216954 /Source="Nicolas_upshifts" /id="D660" /incds=0 /nref=215 /ntot=271 /MaxReadThrough="1.63272" /MaxDrop="7.26386" /score="22.0381158" /energy="-7.2" /TU="NA" /idTUdmin="U969" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts complement(1216986) /Source="Nicolas_upshifts" /id="U973" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.828171828171828" /psig="0.107892107892108" /xcortree=80 /SigmaFactorBS="tcctgagacttaccggaagcagtttacagggaacaaaaaaag caccCCGCaggatgctcttattatttaatccaatctttaatctctttaatggtcttat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(1216997..1217000) /Source="Nicolas_upshift_promotors" /id="U973" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.828171828171828" /psig="0.107892107892108" /xcortree=80 /SigmaFactorBS="tcctgagacttaccggaagcagtttacagggaacaaaaaaag caccCCGCaggatgctcttattatttaatccaatctttaatctctttaatggtcttat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 1217145..1217672 /gene="yjcR" /locus_tag="BSU_11960" /old_locus_tag="BSU11960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7489895, 7704261; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phage-related nucleic acid binding terminase small subunit; phage island" /protein_id="NP_389078.1" /db_xref="EnsemblGenomes-Gn:BSU11960" /db_xref="EnsemblGenomes-Tr:CAB13053" /db_xref="GOA:O31640" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR010332" /db_xref="SubtiList:BG13171" /db_xref="UniProtKB/Swiss-Prot:O31640" /translation="MAEKHIQAYKDYVKGMKYKDLAEKYGVSVNTIKSWKQRHGWERK KGAPIEKSVHTKKGGQPGNKNALGNNGGAPQKNQNAVTHGFFSKFLPEETLEIMEEIQ ERSPADMIWDQIQIQYAAILRAQKIMFVSDKEEMIKELKKKRSLISEVSEIEDGLVIS FSTWFRYRLYSETNT*" /label="yjcR CDS" gene 1217145..1217672 /gene="yjcR" /locus_tag="BSU_11960" /old_locus_tag="BSU11960" /label="yjcR gene" promotor_-35 1217819..1217824 /Source="Nicolas_upshift_promotors" /id="U974" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.748251748251748" /psig="0.992007992007992" /xcortree=2218 /SigmaFactorBS="tacagcgattgattaactcgagcaatcaatgtcgcagttATA TTTatttttcaagaaAATGTTATAATGAAAAGCCAtaaaatgatgggagggggaattt c" /listShort="yjcS, S435, yjdA, S436" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1217837..1217856 /Source="Nicolas_upshift_promotors" /id="U974" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.748251748251748" /psig="0.992007992007992" /xcortree=2218 /SigmaFactorBS="tacagcgattgattaactcgagcaatcaatgtcgcagttATA TTTatttttcaagaaAATGTTATAATGAAAAGCCAtaaaatgatgggagggggaattt c" /listShort="yjcS, S435, yjdA, S436" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1217840 /Source="Nicolas_upshifts" /id="U974" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.748251748251748" /psig="0.992007992007992" /xcortree=2218 /SigmaFactorBS="tacagcgattgattaactcgagcaatcaatgtcgcagttATA TTTatttttcaagaaAATGTTATAATGAAAAGCCAtaaaatgatgggagggggaattt c" /listShort="yjcS, S435, yjdA, S436" /GFF_Attribute="listLong" /label="upshifts" CDS 1217846..1218163 /gene="yjcS" /locus_tag="BSU_11970" /old_locus_tag="BSU11970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; phage island" /protein_id="NP_389079.1" /db_xref="EnsemblGenomes-Gn:BSU11970" /db_xref="EnsemblGenomes-Tr:CAB13054" /db_xref="GOA:O31641" /db_xref="InterPro:IPR007138" /db_xref="InterPro:IPR011008" /db_xref="PDB:1Q8B" /db_xref="SubtiList:BG13172" /db_xref="UniProtKB/Swiss-Prot:O31641" /translation="MKSHKMMGGGISMHYITACLKIISDKDLNEIMKEFKKLEEETNK EEGCITFHAYPLEPSERKIMLWEIWENEEAVKIHFTKKHTIDVQKQELTEVEWLMKSN VND*" /label="yjcS CDS" gene 1217846..1218163 /gene="yjcS" /locus_tag="BSU_11970" /old_locus_tag="BSU11970" /label="yjcS gene" S_feature 1218164..1218399 /Source="Nicolas_S_feature" /locus_tag="new_1268593_1268828" /HighExp="dia5, H2O2, dia15, dia0, Lbexp, Lbtran, C90, Oxctl, S1, aero" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S435" CDS 1218400..1219155 /gene="yjdA" /locus_tag="BSU_11980" /old_locus_tag="BSU11980" /EC_number="1.1.1.-" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 2243795; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyl-carrier protein oxidoreductase; phage island" /protein_id="NP_389080.1" /db_xref="EnsemblGenomes-Gn:BSU11980" /db_xref="EnsemblGenomes-Tr:CAB13055" /db_xref="GOA:O31642" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13173" /db_xref="UniProtKB/Swiss-Prot:O31642" /translation="MSHSQEKIALITGASSQGDIGTAICRKLASQGIHIFFTHWNSDT AWIEEFQQEILRMGVRCEAMKIDLSDAHAAFTIHEKISDKLGYPSILINNAAHSASDN YVSLDAKSLDEHYAVNMRSNFLLCVEFARRFKKSNLISGRIINMTSGQDLGPLPGELA YAATKGAISAFTRSLSQELAPLGITVNAVNPGPTDSTWMTDEIRNFLSPKFPMGRIGT PDDAARMIAFLASDEAEWITGQIIHSEGGFIRG*" /label="yjdA CDS" gene 1218400..1219155 /gene="yjdA" /locus_tag="BSU_11980" /old_locus_tag="BSU11980" /label="yjdA gene" S_feature 1219156..1219243 /Source="Nicolas_S_feature" /locus_tag="new_1269585_1269672" /HighExp="C90, S1, dia0, dia5, Mt0, Lbexp, Gly, H2O2, Oxctl, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S436" downshifts 1219200 /Source="Nicolas_upshifts" /id="D661" /incds=0 /nref=89 /ntot=238 /MaxReadThrough="2.66489" /MaxDrop="5.39812" /score="-0.84766737" /energy="-14.2" /TU="NA" /idTUdmin="U974" /TUdmin="-20" /isTUend="TRUE" /label="downshifts" S_feature complement(1219243..1219303) /Source="Nicolas_S_feature" /locus_tag="new_1269672_1269732_c" /HighExp="Lbstat, BI, BT, nit, S2, ferm, B60, B36, M0t90, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S437" downshifts complement(1219274) /Source="Nicolas_upshifts" /id="D662" /incds=0 /nref=80 /ntot=134 /MaxReadThrough="1.9707" /MaxDrop="7.43843" /score="-5.56180712" /energy="-14.2" /TU="NA" /idTUdmin="U975" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1219304..1219651) /gene="yjdB" /locus_tag="BSU_11990" /old_locus_tag="BSU11990" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16291680; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative exported protein; phage island" /protein_id="NP_389081.1" /db_xref="EnsemblGenomes-Gn:BSU11990" /db_xref="EnsemblGenomes-Tr:CAB13056" /db_xref="InterPro:IPR003343" /db_xref="InterPro:IPR008964" /db_xref="SubtiList:BG13174" /db_xref="UniProtKB/Swiss-Prot:O31643" /translation="MNFKKTVVSALSISALALSVSGVASAHEINSTPTEVKNISISPT HVIKIQDYNLPLKVGETYSVKNNSATRYWTDNQKVAEVDQNGLVTAKSKGKATITLFK GTAVFGKVYVTVY*" /label="yjdB CDS" gene complement(1219304..1219651) /gene="yjdB" /locus_tag="BSU_11990" /old_locus_tag="BSU11990" /label="yjdB gene" promotor_-10 complement(1219683..1219701) /Source="Nicolas_upshift_promotors" /id="U975" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=507 /SigmaFactorBS="tcaattgatcgttcacatattattaacatttatttaCAAGGA AAAtaattactttTATTGAATTGTTATAGTGCaagacaaaaaactttaaaggagtgtt t" /listShort="yjdB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1219696) /Source="Nicolas_upshifts" /id="U975" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=507 /SigmaFactorBS="tcaattgatcgttcacatattattaacatttatttaCAAGGA AAAtaattactttTATTGAATTGTTATAGTGCaagacaaaaaactttaaaggagtgtt t" /listShort="yjdB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1219698..1220154) /Source="Nicolas_S_feature" /locus_tag="new_1270127_1270583_c" /HighExp="T1.30H, T2.0H, T2.30H, T3.0H, M9-stat, T1.0H, Lbstat, T3.30H, M0t90, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.983" /TUlongSig="NA" /TUlongPSig="NA" /label="S438" promotor_-35 complement(1219712..1219720) /Source="Nicolas_upshift_promotors" /id="U975" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=507 /SigmaFactorBS="tcaattgatcgttcacatattattaacatttatttaCAAGGA AAAtaattactttTATTGAATTGTTATAGTGCaagacaaaaaactttaaaggagtgtt t" /listShort="yjdB" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 1220114..1220132 /Source="Nicolas_upshift_promotors" /id="U976" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.33966033966034" /psig="0.99100899100899" /xcortree=1564 /SigmaFactorBS="tttttccggaagcttcggtaaaaaacgaaacttttgtctcta tgatttTGTTTTATAATGTAAACGGtttcttatatagtatacttatactatcaatttg c" /listShort="manR" /listLong="manP, manA, S439, S440, yjdF, yjdI" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1220126 /Source="Nicolas_upshifts" /id="U976" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.33966033966034" /psig="0.99100899100899" /xcortree=1564 /SigmaFactorBS="tttttccggaagcttcggtaaaaaacgaaacttttgtctcta tgatttTGTTTTATAATGTAAACGGtttcttatatagtatacttatactatcaatttg c" /listShort="manR" /listLong="manP, manA, S439, S440, yjdF, yjdI" /label="upshifts" promotor_-10 complement(1220132..1220151) /Source="Nicolas_upshift_promotors" /id="U977" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.572427572427572" /psig="0.983016983016983" /xcortree=327 /SigmaFactorBS="ttatgtattccatctgtttttctatccttcctgtcagtatct ACTTGAGCaaattgatagtatAAGTATACTATATAAGAAACcgtttacattataaaac a" /listShort="S438, yjdB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1220154) /Source="Nicolas_upshifts" /id="U977" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.572427572427572" /psig="0.983016983016983" /xcortree=327 /SigmaFactorBS="ttatgtattccatctgtttttctatccttcctgtcagtatct ACTTGAGCaaattgatagtatAAGTATACTATATAAGAAACcgtttacattataaaac a" /listShort="S438, yjdB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1220165..1220172) /Source="Nicolas_upshift_promotors" /id="U977" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.572427572427572" /psig="0.983016983016983" /xcortree=327 /SigmaFactorBS="ttatgtattccatctgtttttctatccttcctgtcagtatct ACTTGAGCaaattgatagtatAAGTATACTATATAAGAAACcgtttacattataaaac a" /listShort="S438, yjdB" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1220202..1222148 /gene="manR" /locus_tag="BSU_12000" /old_locus_tag="BSU12000" /function="16.1: Circulate" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10438772, 10960106, 23551403" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10438772, 10960106, 23551403; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional DNA-binding activator" /protein_id="NP_389082.2" /db_xref="EnsemblGenomes-Gn:BSU12000" /db_xref="EnsemblGenomes-Tr:CAB13057" /db_xref="GOA:O31644" /db_xref="InterPro:IPR002178" /db_xref="InterPro:IPR007737" /db_xref="InterPro:IPR011608" /db_xref="InterPro:IPR013011" /db_xref="InterPro:IPR013196" /db_xref="InterPro:IPR016152" /db_xref="InterPro:IPR036095" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036634" /db_xref="SubtiList:BG13175" /db_xref="UniProtKB/Swiss-Prot:O31644" /translation="MEYINTRQKEILYLLLSEPDDYLVVQDFADRVQCSEKTIRNDLK VIEDYLNEHSHAQLIRKPGLGVYLHIEEQERTWLSQQLHTEHFSSRQRSDKERMLHIA YDLLMNPKPVSAKDIAARHFVNRSSIKKDLYAVEEWLKRFDLTLVSRQRLGLKVEGNE RNKRKALARISDLIHNTAFTSQFIKSKFLHYEVDFVTKEIKSLQKKHSLYFTDETFES LLLHTLLMVRRIKMKQPISLSPKEMAAVKKKKEYQWTFACLQRLEPVFAIRFPEEEAV YLTLHILGGKVRYPLQTEENLENAVLPKVVGHLINRVSELKMMDFHKDQDLINGLNIH LNTVLQRLSYDLSVANPMLNDIKKMYPYLFHLIIDVLEDINQTFDLHIPEEEAAYLTL HFQAAIERMQGSSETHKKAVIVCHMGIGMSQLLRTKIERKYHQIAVMACIAKADLKDY IKKHEDIDLVISTIALENITVPHIVVSPLLEPGEEKKLSAFIRQLGESHRQKQKTFQM LNNTTPFLVFLQQEAEHRYKLIEQLATALFEKGYVDKDYAVHAVMREKMSATNIGSGI AIPHANAKFIKQSAIAIATLKEPLEWGNEKVSLVFMLAVKHEDQTMTKQLFSELSYLS EQPAFVQKLTKETNVMTFLSHLDY*" /label="manR CDS" gene 1220202..1222148 /gene="manR" /locus_tag="BSU_12000" /old_locus_tag="BSU12000" /label="manR gene" downshifts 1222124 /Source="Nicolas_upshifts" /id="D663" /incds=0 /nref=3 /ntot=35 /MaxReadThrough="4.64475" /MaxDrop="3.79938" /score="28.4199725" /energy="-9.1" /TU="U976" /idTUdmin="U976" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" SCAR 1222178..1222179 /note="deletion occured in betwen marked nucleotides" /created_by="User" /label="IIG_Bs02" S_feature <1222179..1222277 /Source="Nicolas_S_feature" /locus_tag="new_1275640_1275738" /HighExp="Oxctl, Lbexp, Paraq, T0.30H, dia0, Diami, H2O2, dia5, Fru, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.15168699999999999" /TUshortSig="SigA" /TUshortPSig="0.936" /TUlongSig="SigA" /TUlongPSig="0.991" /label="S439" promotor_-35 1222252..1222258 /Source="Nicolas_upshift_promotors" /id="U980" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.463536463536464" /psig="0.995004995004995" /xcortree=2151 /SigmaFactorBS="ctattctccagcaatgatctaaataaaataagaGTTTAATag ttggagaagaaaTGTTACACTCTTTTCTGTATatggtaaagaatgaaaaaacacgatt c" /listShort="S440, yjdF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1222273..1222292 /Source="Nicolas_upshift_promotors" /id="U980" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.463536463536464" /psig="0.995004995004995" /xcortree=2151 /SigmaFactorBS="ctattctccagcaatgatctaaataaaataagaGTTTAATag ttggagaagaaaTGTTACACTCTTTTCTGTATatggtaaagaatgaaaaaacacgatt c" /listShort="S440, yjdF" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1222279..1222347 /Source="Nicolas_S_feature" /locus_tag="new_1275740_1275808" /HighExp="Oxctl, Lbexp, Paraq, T0.30H, dia0, Diami, dia5, Fru, H2O2, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.995, 0.936" /TUlongSig="SigA" /TUlongPSig="0.991" /label="S440" upshifts 1222279 /Source="Nicolas_upshifts" /id="U980" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.463536463536464" /psig="0.995004995004995" /xcortree=2151 /SigmaFactorBS="ctattctccagcaatgatctaaataaaataagaGTTTAATag ttggagaagaaaTGTTACACTCTTTTCTGTATatggtaaagaatgaaaaaacacgatt c" /listShort="S440, yjdF" /GFF_Attribute="listLong" /label="upshifts" CDS 1222348..1222830 /gene="yjdF" /locus_tag="BSU_12030" /old_locus_tag="BSU12030" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 20139185" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389085.1" /db_xref="EnsemblGenomes-Gn:BSU12030" /db_xref="EnsemblGenomes-Tr:CAB13060" /db_xref="InterPro:IPR016787" /db_xref="SubtiList:BG13178" /db_xref="UniProtKB/Swiss-Prot:O31647" /translation="MSVTFPSSGCPSFFNIFYEEGIVMKLTIYYDGQFWVGVVEVVDN GKLRAFRHLFGKEPRDSEVLEFVHNQLLNMMAQAEQEGVRLQGRRQKKINPKRLQRQV SKELKNAGVTSKAQEAIKLELEARKQKKKQIMKEQREHVKEQRYMLKKQKAKKKHRGK *" /label="yjdF CDS" gene 1222348..1222830 /gene="yjdF" /locus_tag="BSU_12030" /old_locus_tag="BSU12030" /label="yjdF gene" downshifts 1222810 /Source="Nicolas_upshifts" /id="D664" /incds=0 /nref=220 /ntot=267 /MaxReadThrough="5.32805" /MaxDrop="7.35641" /score="7.68574519" /energy="-10.2" /TU="U978" /idTUdmin="U980" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(1222876..1223382) /gene="yjdG" /locus_tag="BSU_12040" /old_locus_tag="BSU12040" /EC_number="2.3.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_389086.1" /db_xref="EnsemblGenomes-Gn:BSU12040" /db_xref="EnsemblGenomes-Tr:CAB13061" /db_xref="GOA:O31648" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13179" /db_xref="UniProtKB/Swiss-Prot:O31648" /translation="MVLLETNRLRLQTIDIPLLDAASKQDHQAIKELGYETNGEWPNS DFFEAIPYFREILVKNNGTKGFDSWIIVKKDNYEIVGGTGFLGDPDENGMIEIGFATN KSHRRKGYCVEAAQKLINWALSRETVSRITARCEHDNLGSQKTLEKLGFILNHKSAEY KHWIYVTK*" /label="yjdG CDS" gene complement(1222876..1223382) /gene="yjdG" /locus_tag="BSU_12040" /old_locus_tag="BSU12040" /label="yjdG gene" downshifts complement(1222900) /Source="Nicolas_upshifts" /id="D665" /incds=0 /nref=13 /ntot=154 /MaxReadThrough="2.51872" /MaxDrop="4.09551" /score="15.8830125" /energy="-9.9" /TU="NA" /idTUdmin="U984" /TUdmin=7 /isTUend="TRUE" /label="downshifts" misc_feature complement(1223407..1223426) /Source="Nicolas_upshift_promotors" /id="U981" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.654345654345654" /psig="0.775224775224775" /xcortree=679 /SigmaFactorBS="aattttttcatctttctctactgccaaggtaccagagaaaat tgttaTATGTTATCATTATTCCCAGtaaaaagaaaagaggattaaatatatggttctc c" /listShort="yjdG" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1223413) /Source="Nicolas_upshifts" /id="U981" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.654345654345654" /psig="0.775224775224775" /xcortree=679 /SigmaFactorBS="aattttttcatctttctctactgccaaggtaccagagaaaat tgttaTATGTTATCATTATTCCCAGtaaaaagaaaagaggattaaatatatggttctc c" /listShort="yjdG" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1223415..1223600) /Source="Nicolas_S_feature" /locus_tag="new_1276876_1277061_c" /HighExp="S5, S4, S7, S6, S8, B36, LoTm, S3, B60, T1.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.289238" /TUshortSig="SigEF, SigWXY" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S441" CDS complement(1223601..1223996) /gene="yjdH" /locus_tag="BSU_12050" /old_locus_tag="BSU12050" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12562816; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="NP_389087.2" /db_xref="EnsemblGenomes-Gn:BSU12050" /db_xref="EnsemblGenomes-Tr:CAB13062" /db_xref="SubtiList:BG13180" /db_xref="UniProtKB/Swiss-Prot:O31649" /translation="MYHYFYGPALIPYFSHTHNPQRSPDFSERQRRREITLTVDGFVP PSSTEDLGDGFYSYAWTNQQVINPGEYLVCHLEGRDINVINGGFTPRDTAPLYAVASF PRRRNQWVIIIHNPVQTQRAISLYLIAKR*" /label="yjdH CDS" gene complement(1223601..1223996) /gene="yjdH" /locus_tag="BSU_12050" /old_locus_tag="BSU12050" /label="yjdH gene" promotor_-10 complement(1224019..1224037) /Source="Nicolas_upshift_promotors" /id="U982" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1101 /SigmaFactorBS="ctatagcccattattagtctacatggaacaaaacaGGAATGa acaaataactcccACATACAATTTGTATGAATggaaaataaaggagtggttgctttgt a" /listShort="yjdH, S441, yjdG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1224032) /Source="Nicolas_upshifts" /id="U982" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1101 /SigmaFactorBS="ctatagcccattattagtctacatggaacaaaacaGGAATGa acaaataactcccACATACAATTTGTATGAATggaaaataaaggagtggttgctttgt a" /listShort="yjdH, S441, yjdG" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1224034..1224734) /Source="Nicolas_S_feature" /locus_tag="new_1277495_1278195_c" /HighExp="T0.30H, T1.0H, T-0.40H, T1.30H, T0.0H, S0, T2.0H, Salt, T2.30H, T-1.10H" /AntisenseName="yjdI" /AntisenseCor="-0.383915151906285" /AntisenseRegPval="-10.1" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S442" promotor_-35 complement(1224052..1224057) /Source="Nicolas_upshift_promotors" /id="U982" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1101 /SigmaFactorBS="ctatagcccattattagtctacatggaacaaaacaGGAATGa acaaataactcccACATACAATTTGTATGAATggaaaataaaggagtggttgctttgt a" /listShort="yjdH, S441, yjdG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1224140..1224147 /Source="Nicolas_upshift_promotors" /id="U983" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2214 /SigmaFactorBS="tgtccttccgttgattcaatgctagtaaCCTTGAAAatgcag gttaggaTGATAGAATTTACATATTACtgcaagaagttagacatacatcattttgata g" /listShort="yjdI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1224161..1224180 /Source="Nicolas_upshift_promotors" /id="U983" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2214 /SigmaFactorBS="tgtccttccgttgattcaatgctagtaaCCTTGAAAatgcag gttaggaTGATAGAATTTACATATTACtgcaagaagttagacatacatcattttgata g" /listShort="yjdI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1224172 /Source="Nicolas_upshifts" /id="U983" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2214 /SigmaFactorBS="tgtccttccgttgattcaatgctagtaaCCTTGAAAatgcag gttaggaTGATAGAATTTACATATTACtgcaagaagttagacatacatcattttgata g" /listShort="yjdI" /GFF_Attribute="listLong" /label="upshifts" CDS 1224225..1224704 /gene="trnE" /locus_tag="BSU_12060" /old_locus_tag="BSU12060" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 22128149; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cys-tRNApro deacetylase; tRNA editing" /protein_id="NP_389088.1" /db_xref="EnsemblGenomes-Gn:BSU12060" /db_xref="EnsemblGenomes-Tr:CAB13063" /db_xref="GOA:O31650" /db_xref="InterPro:IPR004369" /db_xref="InterPro:IPR007214" /db_xref="InterPro:IPR036754" /db_xref="SubtiList:BG13181" /db_xref="UniProtKB/Swiss-Prot:O31650" /translation="MAKKMAKTNAVRLIEQQNISYEVLGYKTDGQPVDGISVAEKIGY SLKYVYKTLVAAAGTNHYYVFVVPVAEELDVKKAAKVTGEKKIEMIAMKELLAVTGYL RGGCSPIGMKKLFPTYIDASAETLDFIIVSAGKIGMQLKLAPQDLARSCDAAFAEIV* " /label="trnE CDS" gene 1224225..1224704 /gene="trnE" /locus_tag="BSU_12060" /old_locus_tag="BSU12060" /label="trnE gene" downshifts 1224703 /Source="Nicolas_upshifts" /id="D666" /incds=0 /nref=4 /ntot=100 /MaxReadThrough="2.68858" /MaxDrop="3.19616" /score="-5.52314972" /energy="-12.5" /TU="NA" /idTUdmin="U978" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1224744..1224938) /gene="yjzH" /locus_tag="BSU_12069" /old_locus_tag="BSU12069" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097709.1" /db_xref="EnsemblGenomes-Gn:BSU12069" /db_xref="EnsemblGenomes-Tr:CAX52599" /db_xref="InterPro:IPR025234" /db_xref="UniProtKB/Swiss-Prot:C0H3Z2" /translation="MKEYEFVRVELSTMRRRPKEDYQQIIHDYAKRGWRFVQIFAPSI DGYGAAAYFEIIFERDAEKA*" /label="yjzH CDS" gene complement(1224744..1224938) /gene="yjzH" /locus_tag="BSU_12069" /old_locus_tag="BSU12069" /label="yjzH gene" downshifts complement(1224779) /Source="Nicolas_upshifts" /id="D667" /incds=0 /nref=6 /ntot=144 /MaxReadThrough="7.83072" /MaxDrop="2.95935" /score="-6.07514027" /energy="-7" /TU="U984" /idTUdmin="U987" /TUdmin=220 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1224952..1224967) /Source="Nicolas_upshift_promotors" /id="U984" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1698 /SigmaFactorBS="tagtgagtgaaatatactttccgaccttaacctaggttttCG GAACTTCTcgctccattttACGTATACCTTAATAGgagggatcaaacgatgaaagaat a" /listShort="yjzH, S442, yjdH, S441, yjdG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1224968) /Source="Nicolas_upshifts" /id="U984" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1698 /SigmaFactorBS="tagtgagtgaaatatactttccgaccttaacctaggttttCG GAACTTCTcgctccattttACGTATACCTTAATAGgagggatcaaacgatgaaagaat a" /listShort="yjzH, S442, yjdH, S441, yjdG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1224979..1224988) /Source="Nicolas_upshift_promotors" /id="U984" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1698 /SigmaFactorBS="tagtgagtgaaatatactttccgaccttaacctaggttttCG GAACTTCTcgctccattttACGTATACCTTAATAGgagggatcaaacgatgaaagaat a" /listShort="yjzH, S442, yjdH, S441, yjdG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1225104..1225433) /gene="yjdJ" /locus_tag="BSU_12070" /old_locus_tag="BSU12070" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389089.1" /db_xref="EnsemblGenomes-Gn:BSU12070" /db_xref="EnsemblGenomes-Tr:CAB13064" /db_xref="GOA:O31651" /db_xref="InterPro:IPR016508" /db_xref="InterPro:IPR025440" /db_xref="SubtiList:BG13182" /db_xref="UniProtKB/Swiss-Prot:O31651" /translation="MKGIFLVVQLGFSIMVFLFLAAVNWYQGSELVSDRFDWNYTAKL SKLLNGIDAVSSPKQISQLDFFIYSAKHYPVMSALMIISFLYVLAALFLLIYSVKCNK QEIHLDC*" /label="yjdJ CDS" gene complement(1225104..1225433) /gene="yjdJ" /locus_tag="BSU_12070" /old_locus_tag="BSU12070" /label="yjdJ gene" promotor_-10 complement(1225470..1225489) /Source="Nicolas_upshift_promotors" /id="U985" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.428571428571429" /psig="0.994005994005994" /xcortree=3103 /SigmaFactorBS="aaatagacttgcgtttgagttgtatggaagtgaaATTGCAag aataacccatacGGTGGTAATATATTGTTTGAttttcccatattcatagatttggagg t" /listShort="yjdJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1225483) /Source="Nicolas_upshifts" /id="U985" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.428571428571429" /psig="0.994005994005994" /xcortree=3103 /SigmaFactorBS="aaatagacttgcgtttgagttgtatggaagtgaaATTGCAag aataacccatacGGTGGTAATATATTGTTTGAttttcccatattcatagatttggagg t" /listShort="yjdJ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1225485..1226052) /Source="Nicolas_S_feature" /locus_tag="new_1278946_1279513_c" /HighExp="S8, S6, nit, S7, ferm, S2, S5, M9-tran, M/G, GM 150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.987, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S443" promotor_-35 complement(1225504..1225509) /Source="Nicolas_upshift_promotors" /id="U985" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.428571428571429" /psig="0.994005994005994" /xcortree=3103 /SigmaFactorBS="aaatagacttgcgtttgagttgtatggaagtgaaATTGCAag aataacccatacGGTGGTAATATATTGTTTGAttttcccatattcatagatttggagg t" /listShort="yjdJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1225537..1225541 /Source="Nicolas_upshift_promotors" /id="U986" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.913086913086913" /psig="0.996003996003996" /xcortree=2745 /SigmaFactorBS="tcttgcaatttcacttccatacaactcaaacgcaagTCTATt tttttgtttgttttTGGCTTATAATACCTGATGAtggaaaaagagtgcgggtttatag a" /listShort="S444" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1225557..1225576 /Source="Nicolas_upshift_promotors" /id="U986" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.913086913086913" /psig="0.996003996003996" /xcortree=2745 /SigmaFactorBS="tcttgcaatttcacttccatacaactcaaacgcaagTCTATt tttttgtttgttttTGGCTTATAATACCTGATGAtggaaaaagagtgcgggtttatag a" /listShort="S444" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1225561..1226062 /Source="Nicolas_S_feature" /locus_tag="new_1279022_1279523" /HighExp="LBGstat, C30, HPh, Oxctl, dia15, Paraq, T0.30H, C90, LBGtran, LPh" /AntisenseName="ctaO" /AntisenseCor="-0.43946575370083102" /AntisenseRegPval="-13.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S444" upshifts 1225561 /Source="Nicolas_upshifts" /id="U986" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.913086913086913" /psig="0.996003996003996" /xcortree=2745 /SigmaFactorBS="tcttgcaatttcacttccatacaactcaaacgcaagTCTATt tttttgtttgttttTGGCTTATAATACCTGATGAtggaaaaagagtgcgggtttatag a" /listShort="S444" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1226053..1227042) /gene="ctaO" /locus_tag="BSU_12080" /old_locus_tag="BSU12080" /EC_number="2.5.1.-" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10675592, 15491161, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10675592, 15491161, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="minor protoheme IX farnesyltransferase 1 (heme Osynthase)" /protein_id="NP_389090.2" /db_xref="EnsemblGenomes-Gn:BSU12080" /db_xref="EnsemblGenomes-Tr:CAB13065" /db_xref="GOA:O31652" /db_xref="InterPro:IPR000537" /db_xref="InterPro:IPR006369" /db_xref="InterPro:IPR030470" /db_xref="SubtiList:BG13183" /db_xref="UniProtKB/Swiss-Prot:O31652" /translation="MQFWGRRLFLENTRDSAAISETKYIKASNRVTIYDFIKLAKPGI IISNSIAAFGGFWIAFASAEKTLTGLAFLMTMVTAMLGTAFVMASGTVYNNYFDRHMD AKMARTRSRASVTGKMPPAMILTYGSVLGIAGLAMLYSLNPLTAFLGLAAFIFYAIIY TVWVKRTSVWSTFVGSFPGAAPPLMGYCAVTGDFSMTAVLLYTIMFLWQPPHFWAIGI RRKEEYRAAGVPLLPVVKGNHVTKIKMMQYIAVLVPVTLLFPFSLGTGHISPFYFLAA LVLGGIWIKKSIKGFKTDDDVKWAKDMFVYSLIYFCLLFFIMMIDSFMMFLIR*" /label="ctaO CDS" gene complement(1226053..1227042) /gene="ctaO" /locus_tag="BSU_12080" /old_locus_tag="BSU12080" /label="ctaO gene" promotor_-10 complement(1227043..1227062) /Source="Nicolas_upshift_promotors" /id="U987" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.36963036963037" /psig="0.987012987012987" /xcortree=2978 /SigmaFactorBS="aatatcatgacaaatatgggaaataATTGTGattctgtcccc ctCTTGTTACGATAACAAAAGCatgcagttttgggggaggcgtctatttttggagaat a" /listShort="ctaO, S443, yjdJ" /listLong="yjzH" /label="promotor_-10" upshifts complement(1227046) /Source="Nicolas_upshifts" /id="U987" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.36963036963037" /psig="0.987012987012987" /xcortree=2978 /SigmaFactorBS="aatatcatgacaaatatgggaaataATTGTGattctgtcccc ctCTTGTTACGATAACAAAAGCatgcagttttgggggaggcgtctatttttggagaat a" /listShort="ctaO, S443, yjdJ" /listLong="yjzH" /label="upshifts" promotor_-35 complement(1227076..1227081) /Source="Nicolas_upshift_promotors" /id="U987" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.36963036963037" /psig="0.987012987012987" /xcortree=2978 /SigmaFactorBS="aatatcatgacaaatatgggaaataATTGTGattctgtcccc ctCTTGTTACGATAACAAAAGCatgcagttttgggggaggcgtctatttttggagaat a" /listShort="ctaO, S443, yjdJ" /listLong="yjzH" /label="promotor_-35" CDS complement(1227165..1227413) /gene="cotT" /locus_tag="BSU_12090" /old_locus_tag="BSU12090" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:1391045, 1917883, 19933362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1391045, 1917883, 19933362; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat protein (inner coat)" /protein_id="NP_389091.2" /db_xref="EnsemblGenomes-Gn:BSU12090" /db_xref="EnsemblGenomes-Tr:CAB13066" /db_xref="GOA:P11863" /db_xref="SubtiList:BG10495" /db_xref="UniProtKB/Swiss-Prot:P11863" /translation="MDYPLNEQSFEQITPYDERQPYYYPRPRPPFYPPYYYPRPYYPF YPFYPRPPYYYPRPRPPYYPWYGYGGGYGGGYGGGYGY*" /label="cotT CDS" gene complement(1227165..1227413) /gene="cotT" /locus_tag="BSU_12090" /old_locus_tag="BSU12090" /label="cotT gene" downshifts complement(1227175) /Source="Nicolas_upshifts" /id="D668" /incds=0 /nref=37 /ntot=82 /MaxReadThrough="5.73194" /MaxDrop="6.23577" /score="25.0951218" /energy="-8.4" /TU="U989" /idTUdmin="U990" /TUdmin=2 /isTUend="TRUE" /label="downshifts" promotor_-35 1227409..1227413 /Source="Nicolas_upshift_promotors" /id="U988" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=705 /SigmaFactorBS="gggtaatttgttcaaatgactgttcattcaaagggtaaTCCA AgaggaaaaCCTCCCTAGCTTTTTttattccttttaccatattcctgatgcttaagtt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1227422..1227436 /Source="Nicolas_upshift_promotors" /id="U988" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=705 /SigmaFactorBS="gggtaatttgttcaaatgactgttcattcaaagggtaaTCCA AgaggaaaaCCTCCCTAGCTTTTTttattccttttaccatattcctgatgcttaagtt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1227431 /Source="Nicolas_upshifts" /id="U988" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=705 /SigmaFactorBS="gggtaatttgttcaaatgactgttcattcaaagggtaaTCCA AgaggaaaaCCTCCCTAGCTTTTTttattccttttaccatattcctgatgcttaagtt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1227438..1227457) /Source="Nicolas_upshift_promotors" /id="U989" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1278 /SigmaFactorBS="ataaaaaaaaccgaatttcatgaatgtACATACACCCaactt aagcatcaGGAATATGGTAAAAGGAATAaaaaaagctagggaggttttcctcttggat t" /listShort="cotT, ctaO, S443" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1227447) /Source="Nicolas_upshifts" /id="U989" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1278 /SigmaFactorBS="ataaaaaaaaccgaatttcatgaatgtACATACACCCaactt aagcatcaGGAATATGGTAAAAGGAATAaaaaaagctagggaggttttcctcttggat t" /listShort="cotT, ctaO, S443" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1227471..1227480) /Source="Nicolas_upshift_promotors" /id="U989" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1278 /SigmaFactorBS="ataaaaaaaaccgaatttcatgaatgtACATACACCCaactt aagcatcaGGAATATGGTAAAAGGAATAaaaaaagctagggaggttttcctcttggat t" /listShort="cotT, ctaO, S443" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1227528..1227535 /Source="Nicolas_upshift_promotors" /id="U991" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.713286713286713" /psig="0.994005994005994" /xcortree=1545 /SigmaFactorBS="ttttatgatgaaattccttaaaaaggATTGACATgaacttct aaatcTCATAGTATTACAAATGTGAaataaatgttactacaatgttacaaaaacattt c" /listShort="S445, yjeA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1227542..1227561) /Source="Nicolas_upshift_promotors" /id="U990" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.433566433566434" /psig="0.684315684315684" /xcortree=2052 /SigmaFactorBS="atctatttagaaatgtttttgtaacattgTAGTAACAtttat ttcacattTGTAATACTATGAGATTTAGaagttcatgtcaatcctttttaaggaattt c" /listShort="cotT" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 1227549..1227568 /Source="Nicolas_upshift_promotors" /id="U991" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.713286713286713" /psig="0.994005994005994" /xcortree=1545 /SigmaFactorBS="ttttatgatgaaattccttaaaaaggATTGACATgaacttct aaatcTCATAGTATTACAAATGTGAaataaatgttactacaatgttacaaaaacattt c" /listShort="S445, yjeA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1227551) /Source="Nicolas_upshifts" /id="U990" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.433566433566434" /psig="0.684315684315684" /xcortree=2052 /SigmaFactorBS="atctatttagaaatgtttttgtaacattgTAGTAACAtttat ttcacattTGTAATACTATGAGATTTAGaagttcatgtcaatcctttttaaggaattt c" /listShort="cotT" /GFF_Attribute="listLong" /label="upshifts" upshifts 1227562 /Source="Nicolas_upshifts" /id="U991" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.713286713286713" /psig="0.994005994005994" /xcortree=1545 /SigmaFactorBS="ttttatgatgaaattccttaaaaaggATTGACATgaacttct aaatcTCATAGTATTACAAATGTGAaataaatgttactacaatgttacaaaaacattt c" /listShort="S445, yjeA" /GFF_Attribute="listLong" /label="upshifts" S_feature 1227563..1227666 /Source="Nicolas_S_feature" /locus_tag="new_1281024_1281127" /HighExp="Heat, T0.30H, T1.0H, ferm, Diami, dia5, T1.30H, M9-stat, T3.0H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S445" promotor_-35 complement(1227575..1227582) /Source="Nicolas_upshift_promotors" /id="U990" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.433566433566434" /psig="0.684315684315684" /xcortree=2052 /SigmaFactorBS="atctatttagaaatgtttttgtaacattgTAGTAACAtttat ttcacattTGTAATACTATGAGATTTAGaagttcatgtcaatcctttttaaggaattt c" /listShort="cotT" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1227667..1229070 /gene="pdaC" /locus_tag="BSU_12100" /old_locus_tag="BSU12100" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:14679227, 17878218, 22277649" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14679227, 17878218, 22277649; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylmuramic acid deacetylase" /protein_id="NP_389092.1" /db_xref="EnsemblGenomes-Gn:BSU12100" /db_xref="EnsemblGenomes-Tr:CAB13067" /db_xref="GOA:O34798" /db_xref="InterPro:IPR002509" /db_xref="InterPro:IPR011330" /db_xref="InterPro:IPR017219" /db_xref="InterPro:IPR021729" /db_xref="InterPro:IPR025303" /db_xref="InterPro:IPR037126" /db_xref="SubtiList:BG13184" /db_xref="UniProtKB/Swiss-Prot:O34798" /translation="MLAKRIKWFHVLIAVVCVVGLIGFFHNHSLKKETVMNKVRTDSQ YGNVEIATLVNDGKTFNYAVNYPVFKNEKMDSALKRFAEKEVRQFQKETKDVDQEHTT KRNELNVDYKIVHYAKQTVAIVFNEYKYIGGAHGQTVKKTFNYDFSKQAFLSIDDIFK EDADYLHKLSLIAYHELKKNKDIAADDALLKEGTAPKKENFSRFAIKEDYIELYFDTY QVAAGYLGEQSIAIKKSLLKDILKEQYIDKAKNKNKIKEQKPKHEVISLPKEETVDPN QKVIALTFDDGPNPATTNQILDSLKKYKGHATFFVLGSRVQYYPETLIRMLKEGNEVG NHSWSHPLLTRLSVKEALKQINDTQDIIEKISGYRPTLVRPPYGGINDELRSQMKMDV ALWDVDPEDWKDRNKKTIVDRVMNQAGDGRTILIHDIYRTSADAADEIIKKLTDQGYQ LVTVSQLEEVKKQREAK*" /label="pdaC CDS" gene 1227667..1229070 /gene="pdaC" /locus_tag="BSU_12100" /old_locus_tag="BSU12100" /label="pdaC gene" downshifts 1229059 /Source="Nicolas_upshifts" /id="D669" /incds=0 /nref=173 /ntot=238 /MaxReadThrough="1.38483" /MaxDrop="6.60322" /score="39.935002" /energy="-13.8" /TU="NA" /idTUdmin="U991" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1229110..1229583) /gene="yjfA" /locus_tag="BSU_12110" /old_locus_tag="BSU12110" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389093.1" /db_xref="EnsemblGenomes-Gn:BSU12110" /db_xref="EnsemblGenomes-Tr:CAB13068" /db_xref="InterPro:IPR021224" /db_xref="SubtiList:BG13185" /db_xref="UniProtKB/Swiss-Prot:O34554" /translation="MKRLFMKASLVLFAVVFVFAVKGAPAKAETHAYDGKSPYYNDCA SSGSTKKSSNLVNASNQVIGVVELKFSSTCKTAWAKITMNNTLTSGYEANAEITRNTD GKRYNCDSAGGNGKAVAGQKSCYTPMVYDLDPRTSYAFGKYSGPNLNVWATTGSY*" /label="yjfA CDS" gene complement(1229110..1229583) /gene="yjfA" /locus_tag="BSU_12110" /old_locus_tag="BSU12110" /label="yjfA gene" downshifts complement(1229114) /Source="Nicolas_upshifts" /id="D670" /incds=0 /nref=33 /ntot=176 /MaxReadThrough="2.25434" /MaxDrop="5.38548" /score="20.5383759" /energy="-13.8" /TU="NA" /idTUdmin="U992" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1229605..1229623) /Source="Nicolas_upshift_promotors" /id="U992" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1105 /SigmaFactorBS="ctccatcctcccggccgcctttattgttcacaaaaaagcaTG CATGttttgattgttcctCCATATGATTTATTGTTTGccatattaaggaggtcataaa t" /listShort="yjfA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1229623) /Source="Nicolas_upshifts" /id="U992" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1105 /SigmaFactorBS="ctccatcctcccggccgcctttattgttcacaaaaaagcaTG CATGttttgattgttcctCCATATGATTTATTGTTTGccatattaaggaggtcataaa t" /listShort="yjfA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1229638..1229643) /Source="Nicolas_upshift_promotors" /id="U992" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1105 /SigmaFactorBS="ctccatcctcccggccgcctttattgttcacaaaaaagcaTG CATGttttgattgttcctCCATATGATTTATTGTTTGccatattaaggaggtcataaa t" /listShort="yjfA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1229708..1229875) /gene="yjfB" /locus_tag="BSU_12120" /old_locus_tag="BSU12120" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15033535" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389094.1" /db_xref="EnsemblGenomes-Gn:BSU12120" /db_xref="EnsemblGenomes-Tr:CAB13069" /db_xref="InterPro:IPR025906" /db_xref="SubtiList:BG13186" /db_xref="UniProtKB/Swiss-Prot:O34438" /translation="MDIPALSVAMHQASLAQNVNIALTKKRLDTAQQNADQTLKMIQH PTLGQTIDVKA*" /label="yjfB CDS" gene complement(1229708..1229875) /gene="yjfB" /locus_tag="BSU_12120" /old_locus_tag="BSU12120" /label="yjfB gene" downshifts complement(1229711) /Source="Nicolas_upshifts" /id="D671" /incds=0 /nref=109 /ntot=232 /MaxReadThrough="3.53249" /MaxDrop="4.93218" /score="-9.08395816" /energy="-13.9" /TU="U993" /idTUdmin="U993" /TUdmin="-576" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1229887..1229905) /Source="Nicolas_upshift_promotors" /id="U993" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2829 /SigmaFactorBS="gggtcaacaagagaaattaagccatttttcaCTGTAAAAtca tacaaacccGCCGATAGGTAAGGCATAGgaggtggaaccatggatattcctgctttat c" /listShort="yjfB, yjfA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1229896) /Source="Nicolas_upshifts" /id="U993" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2829 /SigmaFactorBS="gggtcaacaagagaaattaagccatttttcaCTGTAAAAtca tacaaacccGCCGATAGGTAAGGCATAGgaggtggaaccatggatattcctgctttat c" /listShort="yjfB, yjfA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1229918..1229925) /Source="Nicolas_upshift_promotors" /id="U993" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2829 /SigmaFactorBS="gggtcaacaagagaaattaagccatttttcaCTGTAAAAtca tacaaacccGCCGATAGGTAAGGCATAGgaggtggaaccatggatattcctgctttat c" /listShort="yjfB, yjfA" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1230002..1230901 /gene="yjfC" /locus_tag="BSU_12130" /old_locus_tag="BSU12130" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389095.2" /db_xref="EnsemblGenomes-Gn:BSU12130" /db_xref="EnsemblGenomes-Tr:CAB13070" /db_xref="InterPro:IPR018728" /db_xref="SubtiList:BG13187" /db_xref="UniProtKB/Swiss-Prot:O34458" /translation="MNLVMEKTFEQYEKLFSMEEQKREDVFRYTMMRPFEKMWTAIQV PLKAKEPNGYDVIMAAKMLGYLDVRDAESGQKALQILKESHVSETAESALRQCIFFAE REQLRVNAKEIKFGLYIADPNKLQLQKGYCGFGGIPGFIHVWINPNSYNLPRIPSIIA HEFHHNVRFSYIDFHHGSVSVGDYLVIEGLAESFARELFGTERLGPWVTRFDHEDLQY SIDVINEVLDVKGFSEVSRYMFGDPIANDQGFKPAGLSAFAGYAVGYHAVQSFMNQHH ITISEATRLDAKTIISQCGLFST*" /label="yjfC CDS" gene 1230002..1230901 /gene="yjfC" /locus_tag="BSU_12130" /old_locus_tag="BSU12130" /label="yjfC gene" CDS complement(1230910..1231308) /gene="yjgA" /locus_tag="BSU_12140" /old_locus_tag="BSU12140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406" /codon_start=1 /transl_table=11 /product="conserved membrane protein" /protein_id="NP_389096.1" /db_xref="EnsemblGenomes-Gn:BSU12140" /db_xref="EnsemblGenomes-Tr:CAB13071" /db_xref="GOA:O35027" /db_xref="InterPro:IPR021257" /db_xref="SubtiList:BG13188" /db_xref="UniProtKB/Swiss-Prot:O35027" /translation="MKRNRWIYAVFTILIIGLGLGSRAFSSVLPDTLNTYLGDSLWAA MIFTGCGFLFRKLKTMITGIISLSFCFVIEFSQLYHAEWIDQIRDTSLGGLVLGYGFL WSDIEAYTIGIAACAAIELLVLGIKKRRCM*" /label="yjgA CDS" gene complement(1230910..1231308) /gene="yjgA" /locus_tag="BSU_12140" /old_locus_tag="BSU12140" /label="yjgA gene" downshifts complement(1230940) /Source="Nicolas_upshifts" /id="D672" /incds=0 /nref=2 /ntot=27 /MaxReadThrough="2.86089" /MaxDrop="2.52307" /score="23.8106216" /energy="-10.1" /TU="U994,U995" /idTUdmin="U995" /TUdmin="-243" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1231337..1231356) /Source="Nicolas_upshift_promotors" /id="U994" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig=1 /xcortree=1954 /SigmaFactorBS="caaaataaacaccctacgcggctattcagccgctttttTAGT GGACaaataaaagctataTTCCTTACAATACAGGGAGAtgaagcagagacggggtatc a" /listShort="yjgA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1231356) /Source="Nicolas_upshifts" /id="U994" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig=1 /xcortree=1954 /SigmaFactorBS="caaaataaacaccctacgcggctattcagccgctttttTAGT GGACaaataaaagctataTTCCTTACAATACAGGGAGAtgaagcagagacggggtatc a" /listShort="yjgA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1231371..1231378) /Source="Nicolas_upshift_promotors" /id="U994" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.915084915084915" /psig=1 /xcortree=1954 /SigmaFactorBS="caaaataaacaccctacgcggctattcagccgctttttTAGT GGACaaataaaagctataTTCCTTACAATACAGGGAGAtgaagcagagacggggtatc a" /listShort="yjgA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1231409..1231984) /gene="yjgB" /locus_tag="BSU_12150" /old_locus_tag="BSU12150" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 1580552" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_389097.1" /db_xref="EnsemblGenomes-Gn:BSU12150" /db_xref="EnsemblGenomes-Tr:CAB13072" /db_xref="InterPro:IPR025453" /db_xref="PDB:4YGT" /db_xref="SubtiList:BG13189" /db_xref="UniProtKB/Swiss-Prot:O34960" /translation="MKKTMSAITAAAAVTSCFTGFGAASFSAPAKAAAQTNTLSENTN QSAAELVKNLYNTAYKGEMPQQAQGLTINKSTKGDVHAAFGEPERPVGGDNRFDLYHW NMGQPGYGFSYHKDMTISEIRYFGTGVERQLNLGGVTPEVLQKQLGPVNRVLTVPFTD EIDYVYDTGRYELHFVIGTDQTADHVNLKAK*" /label="yjgB CDS" gene complement(1231409..1231984) /gene="yjgB" /locus_tag="BSU_12150" /old_locus_tag="BSU12150" /label="yjgB gene" downshifts complement(1231424) /Source="Nicolas_upshifts" /id="D673" /incds=0 /nref=3 /ntot=16 /MaxReadThrough="5.38565" /MaxDrop="3.9021" /score="23.8106216" /energy="-10.1" /TU="U995" /idTUdmin="U995" /TUdmin="-727" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1232003..1232021) /Source="Nicolas_upshift_promotors" /id="U995" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=183 /SigmaFactorBS="tacaacaactcaataaaacatacaaagcgcactcacaTGTTT CGttgcaaaaacacgGGGAAACGGAATGGTAGATcaattaggagggattaacatgaaa a" /listShort="yjgB, yjgA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1232018) /Source="Nicolas_upshifts" /id="U995" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=183 /SigmaFactorBS="tacaacaactcaataaaacatacaaagcgcactcacaTGTTT CGttgcaaaaacacgGGGAAACGGAATGGTAGATcaattaggagggattaacatgaaa a" /listShort="yjgB, yjgA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1232035..1232041) /Source="Nicolas_upshift_promotors" /id="U995" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=183 /SigmaFactorBS="tacaacaactcaataaaacatacaaagcgcactcacaTGTTT CGttgcaaaaacacgGGGAAACGGAATGGTAGATcaattaggagggattaacatgaaa a" /listShort="yjgB, yjgA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1232059..1232065 /Source="Nicolas_upshift_promotors" /id="U996" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=186 /SigmaFactorBS="ccgtgtttttgcaacgaaacatgtgagtgcgctttgtaTGTT TTAttgagttgttgtaaGGGAACTGAAATAGGTAATtcggtatataaagcaagaaagg g" /listShort="yjgC, yjgD, S446, yjhA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1232080..1232098 /Source="Nicolas_upshift_promotors" /id="U996" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=186 /SigmaFactorBS="ccgtgtttttgcaacgaaacatgtgagtgcgctttgtaTGTT TTAttgagttgttgtaaGGGAACTGAAATAGGTAATtcggtatataaagcaagaaagg g" /listShort="yjgC, yjgD, S446, yjhA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1232081 /Source="Nicolas_upshifts" /id="U996" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=186 /SigmaFactorBS="ccgtgtttttgcaacgaaacatgtgagtgcgctttgtaTGTT TTAttgagttgttgtaaGGGAACTGAAATAGGTAATtcggtatataaagcaagaaagg g" /listShort="yjgC, yjgD, S446, yjhA" /GFF_Attribute="listLong" /label="upshifts" CDS 1232130..1235087 /gene="yjgC" /locus_tag="BSU_12160" /old_locus_tag="BSU12160" /EC_number="1.2.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative molybdoenzyme; putative formate dehydrogenase" /protein_id="NP_389098.1" /db_xref="EnsemblGenomes-Gn:BSU12160" /db_xref="EnsemblGenomes-Tr:CAB13073" /db_xref="GOA:O34720" /db_xref="InterPro:IPR001041" /db_xref="InterPro:IPR006478" /db_xref="InterPro:IPR006656" /db_xref="InterPro:IPR006657" /db_xref="InterPro:IPR006963" /db_xref="InterPro:IPR009010" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR017896" /db_xref="InterPro:IPR017900" /db_xref="InterPro:IPR019574" /db_xref="InterPro:IPR036010" /db_xref="SubtiList:BG13190" /db_xref="UniProtKB/Swiss-Prot:O34720" /translation="MAGKKTITINGVEMEASEEQTVLQLLNNSSIEVPQVCYHPSLGP IETCDTCIVSINGELKRSCSAELKDGDVIDTLSPDVKKAQVIGMDKILYNHELYCTVC DYNNGGCEIHNTVKEMKINHQSIPFDHKPYHKDESHPFYRYDPDQCILCGRCVEACQD VQVTETLTIDWERKRPRVIWDNDVPINESSCVSCGHCSTVCPCNAMMEKGMEGEAGYL TGINNETLRPMIEITKGVETGYGSILAISDMESAMRDERIKKTKTVCTYCGVGCSFDV WTKGRDILKVEPQEEAPANGISTCVKGKFGWDFVNSEERLTKPLIREGDHFREAEWEE ALLLIASKFTELKEAFGPDSLAFITSSKCTNEESYLMQKLARGVIGTNNVDNCSRYCQ SPATAGLFRTVGYGGDSGSITDIAQADLVLIIGSNTSESHPVLSTRIKRAHKLRGQKV IVADIRKHEMAERSDLFVQPRAGSDIVWLNAIAKYLIENGKADERFLRERVNGRDEYV KSLAPYTLEYAEEKTGIDQETLIQMAEMIGQADSVCALWAMGVTQHIGGSDTSTAISN LLLVTGNYGKPGAGSYPLRGHNNVQGASDFGSMPDRLPGYEKVTDEQVRQKYERVWGV PLPKEPGMTNHEMIEKIHSGQLKAMYVKGEEMGLVDSNINHVHAAYEKLDFFVVQDIF LSRTAEFADVVLPASPSLEKEGTFTNTERRIQRLYQVFEPLGESKPDWQIIMEVANKL GAGWLYEHPADIMEEAAKLSPIYAGVTYERLEGYNSLQWPVNADGKDSPLLFTERFPF PDGKAILYPVQWTEPKEFGEEYDIHVNNGRLLEHFHEGNLTYKSKGISEKTPEVFLEI SPELAAERGIQDGTLVRLTSPFGNVKVKCLITDRVKGKEVYLPMNDSGEAAINLLTGS HADKDTDTPAYKETSAKMEILKHDGISPLPKINHRNGNPQPQIGVQVHKKWARKDYIF PGDAVKRGMGHNG*" /label="yjgC CDS" gene 1232130..1235087 /gene="yjgC" /locus_tag="BSU_12160" /old_locus_tag="BSU12160" /label="yjgC gene" CDS 1235080..1235640 /gene="yjgD" /locus_tag="BSU_12170" /old_locus_tag="BSU12170" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389099.1" /db_xref="EnsemblGenomes-Gn:BSU12170" /db_xref="EnsemblGenomes-Tr:CAB13074" /db_xref="InterPro:IPR012440" /db_xref="SubtiList:BG13191" /db_xref="UniProtKB/Swiss-Prot:O34681" /translation="MAKAIKRIQKIEVTEEDQRKRDLREIEDALIDHKEAILETLHML GHMNERGVLPLLRGLFGQGDKVLDILVKKADTEETANTLKNLLLLFGTLGMLDVKQLE PLILKVNAGVASAVEQKNSEEKTGYFDIIRSLKDPEINKSITLLFSFLKGMGQDTKEL ERTTQPPEHQKHHQEPREKRGMNKRD*" /label="yjgD CDS" gene 1235080..1235640 /gene="yjgD" /locus_tag="BSU_12170" /old_locus_tag="BSU12170" /label="yjgD gene" downshifts 1235633 /Source="Nicolas_upshifts" /id="D674" /incds=0 /nref=18 /ntot=84 /MaxReadThrough="5.25706" /MaxDrop="6.46184" /score="20.7921843" /energy="-15" /TU="U996" /idTUdmin="U996" /TUdmin="-819" /isTUend="FALSE" /label="downshifts" S_feature 1235678..1235796 /Source="Nicolas_S_feature" /locus_tag="new_1289139_1289257" /HighExp="Etha, Salt, Heat, S8, M9-stat, S7, LPhT, G135, C30, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S446" promotor_-35 1235774..1235777 /Source="Nicolas_upshift_promotors" /id="U997" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.998001998001998" /xcortree=2980 /SigmaFactorBS="tgatgaatgagatagaaataatcgttactttcttacCTGTta agaaaagggaaaaTCTGATTATAATAGAAATCGattactttagatgggggaacaatca t" /listShort="yjhA, yjhB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1235793..1235812 /Source="Nicolas_upshift_promotors" /id="U997" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.998001998001998" /xcortree=2980 /SigmaFactorBS="tgatgaatgagatagaaataatcgttactttcttacCTGTta agaaaagggaaaaTCTGATTATAATAGAAATCGattactttagatgggggaacaatca t" /listShort="yjhA, yjhB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1235798 /Source="Nicolas_upshifts" /id="U997" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.998001998001998" /xcortree=2980 /SigmaFactorBS="tgatgaatgagatagaaataatcgttactttcttacCTGTta agaaaagggaaaaTCTGATTATAATAGAAATCGattactttagatgggggaacaatca t" /listShort="yjhA, yjhB" /GFF_Attribute="listLong" /label="upshifts" CDS 1235837..1236478 /gene="yjhA" /locus_tag="BSU_12180" /old_locus_tag="BSU12180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_389100.1" /db_xref="EnsemblGenomes-Gn:BSU12180" /db_xref="EnsemblGenomes-Tr:CAB13075" /db_xref="GOA:O34725" /db_xref="InterPro:IPR029050" /db_xref="InterPro:IPR029051" /db_xref="PDB:3CFU" /db_xref="SubtiList:BG13192" /db_xref="UniProtKB/Swiss-Prot:O34725" /translation="MKKVLLLLFVLTIGLALSACSQSSDASEKEKPKEKKSQEELEKE LDKELKKGGEPKTKKDDQIHKIGETFKAGHTNFTVNKVDRVQKGEYMNVGGAVNEETK TIKDDEERLIIEVTMENIGEDSISYNFIGFDLRDKNDQSVRPVFSIEEKGRILMGGTL VSGKKVTGVLSYVIPKGEQKHYTLVYNPFLADTNSSNTEERVKDDIDYLVKLD*" /label="yjhA CDS" gene 1235837..1236478 /gene="yjhA" /locus_tag="BSU_12180" /old_locus_tag="BSU12180" /label="yjhA gene" downshifts complement(1235846) /Source="Nicolas_upshifts" /id="D675" /incds=0 /nref=7 /ntot=57 /MaxReadThrough="2.5769" /MaxDrop="3.81596" /score="-9.34186213" /energy="-3" /TU="NA" /idTUdmin="U998" /TUdmin=1386 /isTUend="FALSE" /label="downshifts" downshifts 1236451 /Source="Nicolas_upshifts" /id="D676" /incds=0 /nref=24 /ntot=186 /MaxReadThrough="4.29897" /MaxDrop="3.4683" /score="19.6571267" /energy="-17" /TU="U997" /idTUdmin="U996" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS 1236557..1237183 /gene="yjhB" /locus_tag="BSU_12190" /old_locus_tag="BSU12190" /EC_number="3.6.1.-" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12483591, 16513759; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ADP-ribose pyrophosphatase" /protein_id="NP_389101.2" /db_xref="EnsemblGenomes-Gn:BSU12190" /db_xref="EnsemblGenomes-Tr:CAB13076" /db_xref="GOA:C0SPC3" /db_xref="InterPro:IPR000086" /db_xref="InterPro:IPR015797" /db_xref="SubtiList:BG13193" /db_xref="UniProtKB/Swiss-Prot:C0SPC3" /translation="MIKVQTKWLERAQRIRAIAQAGLAFSKDVYDRERYEELMKLSAE MMADYSEKDIEVITDLWQGEKGYPTPKADVRGAVFRENQILLVREKHDELWSLPGGFC EIGLSPAENVVKEIKEESGYDTEPSRLLAVLDSHKHSHPPQPYHYYKIFIACSMTDGQ GETGIETNHAAFFPEDRLPPLSPKRNTPSQLSMLFDFLRHPDKKTIFD*" /label="yjhB CDS" gene 1236557..1237183 /gene="yjhB" /locus_tag="BSU_12190" /old_locus_tag="BSU12190" /label="yjhB gene" downshifts 1237185 /Source="Nicolas_upshifts" /id="D677" /incds=0 /nref=97 /ntot=202 /MaxReadThrough="0.597580000000001" /MaxDrop="6.62023" /score="12.2319602" /energy="-7" /TU="NA" /idTUdmin="U997" /TUdmin=7 /isTUend="TRUE" /label="downshifts" downshifts complement(1237188) /Source="Nicolas_upshifts" /id="D678" /incds=0 /nref=1 /ntot=9 /MaxReadThrough="0.18907" /MaxDrop="3.31161" /score="10.5815896" /energy="-7" /TU="NA" /idTUdmin="U998" /TUdmin=44 /isTUend="FALSE" /label="downshifts" CDS complement(1237214..1237492) /gene="yjiA" /locus_tag="BSU_12200" /old_locus_tag="BSU12200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 14563871" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_389102.1" /db_xref="EnsemblGenomes-Gn:BSU12200" /db_xref="EnsemblGenomes-Tr:CAB13077" /db_xref="SubtiList:BG13194" /db_xref="UniProtKB/Swiss-Prot:O34679" /translation="MAAQTDYKKQVVGILLSLAFVLFVFSFSERHEKPLVEGKKQENW HTVVDKASVKIYGSRLVEENKLKQKLGHKQADSILTLLKLANEKHITL*" /label="yjiA CDS" gene complement(1237214..1237492) /gene="yjiA" /locus_tag="BSU_12200" /old_locus_tag="BSU12200" /label="yjiA gene" downshifts complement(1237232) /Source="Nicolas_upshifts" /id="D679" /incds=0 /nref=162 /ntot=247 /MaxReadThrough="1.96302" /MaxDrop="5.98058" /score="10.5815896" /energy="-7" /TU="NA" /idTUdmin="U998" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1237521..1237532) /Source="Nicolas_upshift_promotors" /id="U998" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.632367632367632" /psig="0.972027972027972" /xcortree=575 /SigmaFactorBS="gtctctgttttcaaccaaatgcactaactccaaaaatgactt tcccattatgtaaaataaTTTGGTTcTATGATTAAATAgaaggtaaaaggtgaaggag a" /listShort="yjiA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1237534..1237540) /Source="Nicolas_upshift_promotors" /id="U998" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.632367632367632" /psig="0.972027972027972" /xcortree=575 /SigmaFactorBS="gtctctgttttcaaccaaatgcactaactccaaaaatgactt tcccattatgtaaaataaTTTGGTTcTATGATTAAATAgaaggtaaaaggtgaaggag a" /listShort="yjiA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(1237540) /Source="Nicolas_upshifts" /id="U998" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.632367632367632" /psig="0.972027972027972" /xcortree=575 /SigmaFactorBS="gtctctgttttcaaccaaatgcactaactccaaaaatgactt tcccattatgtaaaataaTTTGGTTcTATGATTAAATAgaaggtaaaaggtgaaggag a" /listShort="yjiA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1237542..1237958) /Source="Nicolas_S_feature" /locus_tag="new_1291003_1291419_c" /HighExp="S6, S7, S8, S5, BT, C30, Pyr, G/S, C90, B36" /AntisenseName="yjiB" /AntisenseCor="-0.25565388711625397" /AntisenseRegPval="-4.7" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S447" upshifts 1237710 /Source="Nicolas_upshifts" /id="U999" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.766233766233766" /psig=1 /xcortree=3183 /SigmaFactorBS="tatgcctaaggtcacgttgtgagccaaaacagcagtgcagaa tagaaaaaaattgaaagatTATGGTAAGATGAACGAAATtcgagggggaatatatgat g" /listShort="S448, yjiB, yjiC" /GFF_Attribute="listLong" /label="upshifts" misc_feature 1237711..1237730 /Source="Nicolas_upshift_promotors" /id="U999" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.766233766233766" /psig=1 /xcortree=3183 /SigmaFactorBS="tatgcctaaggtcacgttgtgagccaaaacagcagtgcagaa tagaaaaaaattgaaagatTATGGTAAGATGAACGAAATtcgagggggaatatatgat g" /listShort="S448, yjiB, yjiC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 1237728..1237882 /Source="Nicolas_S_feature" /locus_tag="new_1291189_1291343" /HighExp="BC, T5.0H, T4.0H, C90, Sw, T3.30H, Lbstat, Diami, dia5, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.995811" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S448" CDS 1237883..1239073 /gene="cypE" /locus_tag="BSU_12210" /old_locus_tag="BSU12210" /EC_number="1.14.-.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:25587700" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25587700; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome P450 CYP109B1, monooxygenase" /protein_id="NP_389103.1" /db_xref="EnsemblGenomes-Gn:BSU12210" /db_xref="EnsemblGenomes-Tr:CAB13078" /db_xref="GOA:O34374" /db_xref="InterPro:IPR001128" /db_xref="InterPro:IPR002397" /db_xref="InterPro:IPR017972" /db_xref="InterPro:IPR036396" /db_xref="PDB:4RM4" /db_xref="SubtiList:BG13195" /db_xref="UniProtKB/Swiss-Prot:O34374" /translation="MNVLNRRQALQRALLNGKNKQDAYHPFPWYESMRKDAPVSFDEE NQVWSVFLYDDVKKVVGDKELFSSCMPQQTSSIGNSIINMDPPKHTKIRSVVNKAFTP RVMKQWEPRIQEITDELIQKFQGRSEFDLVHDFSYPLPVIVISELLGVPSAHMEQFKA WSDLLVSTPKDKSEEAEKAFLEERDKCEEELAAFFAGIIEEKRNKPEQDIISILVEAE ETGEKLSGEELIPFCTLLLVAGNETTTNLISNAMYSILETPGVYEELRSHPELMPQAV EEALRFRAPAPVLRRIAKRDTEIGGHLIKEGDMVLAFVASANRDEAKFDRPHMFDIRR HPNPHIAFGHGIHFCLGAPLARLEANIALTSLISAFPHMECVSITPIENSVIYGLKSF RVKM*" /label="cypE CDS" gene 1237883..1239073 /gene="cypE" /locus_tag="BSU_12210" /old_locus_tag="BSU12210" /label="cypE gene" promotor_-10 complement(1237956..1237975) /Source="Nicolas_upshift_promotors" /id="U1000" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1374 /SigmaFactorBS="ggttttcttcatcaaaggaaACAGGCGCATcctttctcatcg aTTCATACCATGGAAACGGATgatacgcatcctgtttgtttttcccattgagcagcgc t" /listShort="S447, yjiA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1237958) /Source="Nicolas_upshifts" /id="U1000" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1374 /SigmaFactorBS="ggttttcttcatcaaaggaaACAGGCGCATcctttctcatcg aTTCATACCATGGAAACGGATgatacgcatcctgtttgtttttcccattgagcagcgc t" /listShort="S447, yjiA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1237989..1237998) /Source="Nicolas_upshift_promotors" /id="U1000" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1374 /SigmaFactorBS="ggttttcttcatcaaaggaaACAGGCGCATcctttctcatcg aTTCATACCATGGAAACGGATgatacgcatcctgtttgtttttcccattgagcagcgc t" /listShort="S447, yjiA" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1239096..1240274 /gene="ppuG" /locus_tag="BSU_12220" /old_locus_tag="BSU12220" /EC_number="2.4.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 24893262, 27444326; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="polyphenols TDP-rhamnosyltransferase, promiscuous" /protein_id="NP_389104.1" /db_xref="EnsemblGenomes-Gn:BSU12220" /db_xref="EnsemblGenomes-Tr:CAB13079" /db_xref="GOA:O34539" /db_xref="InterPro:IPR002213" /db_xref="InterPro:IPR006326" /db_xref="InterPro:IPR007235" /db_xref="SubtiList:BG13196" /db_xref="UniProtKB/Swiss-Prot:O34539" /translation="MKKYHISMINIPAYGHVNPTLALVEKLCEKGHRVTYATTEEFAP AVQQAGGEALIYHTSLNIDPKQIREMMEKNDAPLSLLKESLSILPQLEELYKDDQPDL IIYDFVALAGKLFAEKLNVPVIKLCSSYAQNESFQLGNEDMLKKIREAEAEFKAYLEQ EKLPAVSFEQLAVPEALNIVFMPKSFQIQHETFDDRFCFVGPSLGERKEKESLLIDKD DRPLMLISLGTAFNAWPEFYKMCIKAFRDSSWQVIMSVGKTIDPESLEDIPANFTIRQ SVPQLEVLEKADLFISHGGMNSTMEAMNAGVPLVVIPQMYEQELTANRVDELGLGVYL PKEEVTVSSLQEAVQAVSSDQELLSRVKNMQKDVKEAGGAERAAAEIEAFMKKSAVPQ *" /label="ppuG CDS" gene 1239096..1240274 /gene="ppuG" /locus_tag="BSU_12220" /old_locus_tag="BSU12220" /label="ppuG gene" CDS complement(1240315..1240503) /gene="yjzI" /locus_tag="BSU_12229" /old_locus_tag="BSU12229" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences" /codon_start=1 /transl_table=11 /product="putative phage protein" /protein_id="YP_003097710.1" /db_xref="EnsemblGenomes-Gn:BSU12229" /db_xref="EnsemblGenomes-Tr:CAX52600" /db_xref="UniProtKB/Swiss-Prot:C0H3Z3" /translation="METKKEEYETKGYDTSIVYEFNEYPDARSGRCDNCDYTLFKSSV KGGKFLRECRRCGMKKNI*" /label="yjzI CDS" gene complement(1240315..1240503) /gene="yjzI" /locus_tag="BSU_12229" /old_locus_tag="BSU12229" /label="yjzI gene" downshifts complement(1240331) /Source="Nicolas_upshifts" /id="D680" /incds=0 /nref=94 /ntot=231 /MaxReadThrough="-0.1433" /MaxDrop="5.1712" /score="13.0160925" /energy="-9.5" /TU="NA" /idTUdmin="U1001" /TUdmin=3 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1240529..1240548) /Source="Nicolas_upshift_promotors" /id="U1001" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.34965034965035" /psig="0.993006993006993" /xcortree=2410 /SigmaFactorBS="agataaacccaacctcctaaaatcCATTGAAtacgccggaag ctTGCTGTAAGATAAACAGCAGacacgtcttgtaacggaggatcgacatggaaaccaa a" /listShort="yjzI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1240532) /Source="Nicolas_upshifts" /id="U1001" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.34965034965035" /psig="0.993006993006993" /xcortree=2410 /SigmaFactorBS="agataaacccaacctcctaaaatcCATTGAAtacgccggaag ctTGCTGTAAGATAAACAGCAGacacgtcttgtaacggaggatcgacatggaaaccaa a" /listShort="yjzI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1240562..1240568) /Source="Nicolas_upshift_promotors" /id="U1001" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.34965034965035" /psig="0.993006993006993" /xcortree=2410 /SigmaFactorBS="agataaacccaacctcctaaaatcCATTGAAtacgccggaag ctTGCTGTAAGATAAACAGCAGacacgtcttgtaacggaggatcgacatggaaaccaa a" /listShort="yjzI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1240590..1240597 /Source="Nicolas_upshift_promotors" /id="U1002" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.356643356643357" /psig="0.982017982017982" /xcortree=2379 /SigmaFactorBS="tcaatggattttaggaggttgggtttaTCTTGATTtctccct tggtttgCGCCAAAATAGCTTTATTAAgcttatatacataaaaagcctatgcaaagag g" /listShort="yjjA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1240612..1240631 /Source="Nicolas_upshift_promotors" /id="U1002" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.356643356643357" /psig="0.982017982017982" /xcortree=2379 /SigmaFactorBS="tcaatggattttaggaggttgggtttaTCTTGATTtctccct tggtttgCGCCAAAATAGCTTTATTAAgcttatatacataaaaagcctatgcaaagag g" /listShort="yjjA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1240623 /Source="Nicolas_upshifts" /id="U1002" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.356643356643357" /psig="0.982017982017982" /xcortree=2379 /SigmaFactorBS="tcaatggattttaggaggttgggtttaTCTTGATTtctccct tggtttgCGCCAAAATAGCTTTATTAAgcttatatacataaaaagcctatgcaaagag g" /listShort="yjjA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1240638..1240657) /Source="Nicolas_upshift_promotors" /id="U1003" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.868131868131868" /psig="0.868131868131868" /xcortree=1376 /SigmaFactorBS="cgttttccaagtaacccttttccCATACCCGtttcctctcct cttTGCATAGGCTTTTTATGTATataagcttaataaagctattttggcgcaaaccaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1240642) /Source="Nicolas_upshifts" /id="U1003" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.868131868131868" /psig="0.868131868131868" /xcortree=1376 /SigmaFactorBS="cgttttccaagtaacccttttccCATACCCGtttcctctcct cttTGCATAGGCTTTTTATGTATataagcttaataaagctattttggcgcaaaccaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1240672..1240679) /Source="Nicolas_upshift_promotors" /id="U1003" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.868131868131868" /psig="0.868131868131868" /xcortree=1376 /SigmaFactorBS="cgttttccaagtaacccttttccCATACCCGtttcctctcct cttTGCATAGGCTTTTTATGTATataagcttaataaagctattttggcgcaaaccaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1240677..1241489 /gene="yjjA" /locus_tag="BSU_12230" /old_locus_tag="BSU12230" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_389105.1" /db_xref="EnsemblGenomes-Gn:BSU12230" /db_xref="EnsemblGenomes-Tr:CAB13080" /db_xref="GOA:O34394" /db_xref="InterPro:IPR003754" /db_xref="InterPro:IPR036108" /db_xref="SubtiList:BG13197" /db_xref="UniProtKB/Swiss-Prot:O34394" /translation="MGKGLLGKRVAIGGSRKTEEISTIIEKQGGIPVIRPLQGTVYLA EKQVEPDLRTFAEEKADWVIFTTGIGLETLVDMAEKIGLKDEFLQAIRQAKAACRGYK TLSALKKLGITPEASDEDGTTRGLIRSLEPHDFSGKTVMVQLHGEKAPALMAFLEEKG ASVLPILPYQHIPPEEETVERLCRELMNDEVDAVCFTTAIQVRSLFDFAKGRGYINEV KKVFEERAIAAAVGKVTAEALREEGITRLLAPEIERMGAMIVELAKYYEEKE*" /label="yjjA CDS" gene 1240677..1241489 /gene="yjjA" /locus_tag="BSU_12230" /old_locus_tag="BSU12230" /label="yjjA gene" downshifts 1241468 /Source="Nicolas_upshifts" /id="D681" /incds=0 /nref=196 /ntot=254 /MaxReadThrough="3.61369" /MaxDrop="5.73094" /score="10.6328997" /energy="-14.5" /TU="U1002" /idTUdmin="U1002" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(1241535..1242287) /gene="yjkA" /locus_tag="BSU_12240" /old_locus_tag="BSU12240" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (permease)" /protein_id="NP_389106.1" /db_xref="EnsemblGenomes-Gn:BSU12240" /db_xref="EnsemblGenomes-Tr:CAB13081" /db_xref="GOA:O34684" /db_xref="InterPro:IPR005226" /db_xref="SubtiList:BG13198" /db_xref="UniProtKB/Swiss-Prot:O34684" /translation="MDYLSLSLTMIFVLIALFLSKSFKAGVEKDMIIATIRAAVQLLI IGYVLSLIFRGDHPVFILLMVLLMLAVAAQNVIKRKKNTIGSFWRVFAALAIVEIVTQ GILLSLHIIPLTARYVIPISGMVIGNSMVLSSLFLNRLNSEVGVRKEEIQLILSLGGT PKQSIQRILTSAMKMSMIPTLESQKTLGLVQLPGMMTGQILAGADPIQAVRFQLLIVF TTMASAALTCVILSVLTYPSLFTVHQQLKQNE*" /label="yjkA CDS" gene complement(1241535..1242287) /gene="yjkA" /locus_tag="BSU_12240" /old_locus_tag="BSU12240" /label="yjkA gene" downshifts complement(1241544) /Source="Nicolas_upshifts" /id="D682" /incds=0 /nref=5 /ntot=153 /MaxReadThrough="0.924970000000001" /MaxDrop="3.5673" /score="13.1058081" /energy="-12.8" /TU="NA" /idTUdmin="U1001" /TUdmin="-1210" /isTUend="FALSE" /label="downshifts" CDS complement(1242287..1243039) /gene="yjkB" /locus_tag="BSU_12250" /old_locus_tag="BSU12250" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_389107.1" /db_xref="EnsemblGenomes-Gn:BSU12250" /db_xref="EnsemblGenomes-Tr:CAB13082" /db_xref="GOA:O34756" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR005670" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13199" /db_xref="UniProtKB/Swiss-Prot:O34756" /translation="MEANDQTQNIPAISFRSVRKSYKQDGQTYDVLQDVTGDIQQGAI VAVLGPSGSGKSTLLSMCNLMRTPDSGEVNIYGKEVREWNVNELRRTAALAFQSAPVL DGTVRDNLSLVQRLHQSQLYSPEKLASLAGLPPELLDRSARDLSGGQRQRLSLARTLS NPSSILLLDEITSALDPVSALEIEELIKRQHQEKKWTVMWVTHNMEQAKRIADTIWFM ADGRLLEIAETDTFFSAPQHEAAKEFLKGGTR*" /label="yjkB CDS" gene complement(1242287..1243039) /gene="yjkB" /locus_tag="BSU_12250" /old_locus_tag="BSU12250" /label="yjkB gene" CDS complement(1243159..1244133) /gene="yjlA" /locus_tag="BSU_12260" /old_locus_tag="BSU12260" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14627822, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_389108.1" /db_xref="EnsemblGenomes-Gn:BSU12260" /db_xref="EnsemblGenomes-Tr:CAB13083" /db_xref="GOA:O34428" /db_xref="InterPro:IPR032713" /db_xref="SubtiList:BG13200" /db_xref="UniProtKB/Swiss-Prot:O34428" /translation="MKAIVIGILASLFFAVTFILNRAMELSGGSWLWSSSLRFIFMVP FLCLIVIMRGTFTPLLLEMRKKPFYWIKWSFVGFVLFYAPITFAAAYGPGWLIAGTWQ ITIVAGVLLSPLFYVKQDMPGGPQLIRQKIPLVSLGTSVIILIGAALIQLQHAESLSG RMLLFSVLPVVIAAFAYPLGNRRMLEEYGGRLDTFQRVLGMTLASLPFWLILAAYGWW SDGLPTASQTVQSFIVAVSSGIIATVLFFWATDMVRDNPQKLAAVEATQSGEVIFALL GEIVLLSGVFPSLLSFAGLFIIIAGMMLHTFASQPRKPKKKAQSNLTA*" /label="yjlA CDS" gene complement(1243159..1244133) /gene="yjlA" /locus_tag="BSU_12260" /old_locus_tag="BSU12260" /label="yjlA gene" downshifts complement(1243194) /Source="Nicolas_upshifts" /id="D683" /incds=0 /nref=1 /ntot=95 /MaxReadThrough="1.84381" /MaxDrop="2.54799" /score="4.80318278" /energy="-14.5" /TU="NA" /idTUdmin="U1004" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1244154..1244173) /Source="Nicolas_upshift_promotors" /id="U1004" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.451548451548452" /psig="0.997002997002997" /xcortree=2386 /SigmaFactorBS="tccacatatagcggttcgccaaacatgatgtttttctcatga ttcCATTGATCtgcatgataccgaaTAGTATAGTATAAAAAAATAatgccagaatgag g" /listShort="yjlA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1244180) /Source="Nicolas_upshifts" /id="U1004" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.451548451548452" /psig="0.997002997002997" /xcortree=2386 /SigmaFactorBS="tccacatatagcggttcgccaaacatgatgtttttctcatga ttcCATTGATCtgcatgataccgaaTAGTATAGTATAAAAAAATAatgccagaatgag g" /listShort="yjlA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1244182..1246688) /Source="Nicolas_S_feature" /locus_tag="new_1297643_1300149_c" /HighExp="Lbstat, S2, M0t90, nit, BT, M40t90, ferm, BC, C30, Gly" /AntisenseName="ndh" /AntisenseCor="-0.74506751931257098" /AntisenseRegPval="-48.1" /CDS_PredictionProba="NA" /TUshortSig="SigH" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S449" promotor_-35 complement(1244188..1244195) /Source="Nicolas_upshift_promotors" /id="U1004" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.451548451548452" /psig="0.997002997002997" /xcortree=2386 /SigmaFactorBS="tccacatatagcggttcgccaaacatgatgtttttctcatga ttcCATTGATCtgcatgataccgaaTAGTATAGTATAAAAAAATAatgccagaatgag g" /listShort="yjlA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1244216..1244222 /Source="Nicolas_upshift_promotors" /id="U1005" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=269 /SigmaFactorBS="atcatgcagatcaatggaatcatgagaaaaacatcaTGTTTG GcgaaccgctatatgTGGAAGACAAAAAAGGGAGgtgaaattgatggaaagagagaca c" /listShort="yjlB, S450, S451, rex, ndh" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1244237..1244255 /Source="Nicolas_upshift_promotors" /id="U1005" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=269 /SigmaFactorBS="atcatgcagatcaatggaatcatgagaaaaacatcaTGTTTG GcgaaccgctatatgTGGAAGACAAAAAAGGGAGgtgaaattgatggaaagagagaca c" /listShort="yjlB, S450, S451, rex, ndh" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1244240 /Source="Nicolas_upshifts" /id="U1005" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=269 /SigmaFactorBS="atcatgcagatcaatggaatcatgagaaaaacatcaTGTTTG GcgaaccgctatatgTGGAAGACAAAAAAGGGAGgtgaaattgatggaaagagagaca c" /listShort="yjlB, S450, S451, rex, ndh" /GFF_Attribute="listLong" /label="upshifts" CDS 1244265..1244762 /gene="yjlB" /locus_tag="BSU_12270" /old_locus_tag="BSU12270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 10704478" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; cupin family" /protein_id="NP_389109.1" /db_xref="EnsemblGenomes-Gn:BSU12270" /db_xref="EnsemblGenomes-Tr:CAB13084" /db_xref="GOA:O34612" /db_xref="InterPro:IPR006045" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014500" /db_xref="InterPro:IPR014710" /db_xref="SubtiList:BG13201" /db_xref="UniProtKB/Swiss-Prot:O34612" /translation="MERETQTYFFPDDGRIPNHPDFPLVVYQNALKDTGLAERIVTRH GWSNSWSGSVFPYHHYHSNTHEVLIALRREAVIQFGGEKGAAIPFKSGDAVVIPAGVG HKKLSSSPDFTVLGAYPGGVQYDMKTGKPNEREEAVKQIKQAALPANDPITGKREPLL EIWVK*" /label="yjlB CDS" gene 1244265..1244762 /gene="yjlB" /locus_tag="BSU_12270" /old_locus_tag="BSU12270" /label="yjlB gene" S_feature 1244763..1244876 /Source="Nicolas_S_feature" /locus_tag="new_1298224_1298337" /HighExp="Etha, M9-stat, B60, Salt, Gly, LPhT, Heat, Sw, HiTm, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S450" promotor_-35 1244856..1244860 /Source="Nicolas_upshift_promotors" /id="U1006" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.618381618381618" /psig=1 /xcortree=2641 /SigmaFactorBS="agctccatataaattaatttcataatcgaagcaattcaCGTT CaaattttgttcaaaaAGTGTTATCATATAGAAGGTaatcgaattggagttttttgtg t" /listShort="S451, rex, ndh" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1244876..1244895 /Source="Nicolas_upshift_promotors" /id="U1006" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.618381618381618" /psig=1 /xcortree=2641 /SigmaFactorBS="agctccatataaattaatttcataatcgaagcaattcaCGTT CaaattttgttcaaaaAGTGTTATCATATAGAAGGTaatcgaattggagttttttgtg t" /listShort="S451, rex, ndh" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1244878..1245150 /Source="Nicolas_S_feature" /locus_tag="new_1298339_1298611" /HighExp="LBGtran, dia5, Lbexp, LBGexp, dia0, HPh, aero, LPh, BMM, MG 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S451" upshifts 1244878 /Source="Nicolas_upshifts" /id="U1006" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.618381618381618" /psig=1 /xcortree=2641 /SigmaFactorBS="agctccatataaattaatttcataatcgaagcaattcaCGTT CaaattttgttcaaaaAGTGTTATCATATAGAAGGTaatcgaattggagttttttgtg t" /listShort="S451, rex, ndh" /GFF_Attribute="listLong" /label="upshifts" CDS 1245151..1245573 /gene="yjlC" /locus_tag="BSU_12280" /old_locus_tag="BSU12280" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16513748, 17015645, 22720735" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389110.1" /db_xref="EnsemblGenomes-Gn:BSU12280" /db_xref="EnsemblGenomes-Tr:CAB13085" /db_xref="InterPro:IPR012440" /db_xref="SubtiList:BG13202" /db_xref="UniProtKB/Swiss-Prot:O34633" /translation="MPETIDQTNASVSQSQQDLIDQLLKPEVQESLTVLVDQLPKLTE LVNILTKSYDFAQSVATDEVLKSDTVGAITEILEPVKETAKEVAATAIEAKDRAEASN ETIGLFGLLRMLKDPQAQKLFRFANSYLEVMNERENQK*" /label="yjlC CDS" gene 1245151..1245573 /gene="yjlC" /locus_tag="BSU_12280" /old_locus_tag="BSU12280" /label="yjlC gene" CDS 1245613..1246791 /gene="ndh" /locus_tag="BSU_12290" /old_locus_tag="BSU12290" /EC_number="1.6.99.-" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:6816592, 16513748, 17015645, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6816592, 16513748, 17015645, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADH dehydrogenase" /protein_id="NP_389111.1" /db_xref="EnsemblGenomes-Gn:BSU12290" /db_xref="EnsemblGenomes-Tr:CAB13086" /db_xref="GOA:P80861" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG13203" /db_xref="UniProtKB/Swiss-Prot:P80861" /translation="MSKHIVILGAGYGGVLSALTVRKHYTKEQARVTVVNKYPTHQII TELHRLAAGNVSEKAVAMPLEKLFKGKDIDLKIAEVSSFSVDKKEVALADGSTLTYDA LVVGLGSVTAYFGIPGLEENSMVLKSAADANKVFQHVEDRVREYSKTKNEADATILIG GGGLTGVELVGELADIMPNLAKKYGVDHKEIKLKLVEAGPKILPVLPDDLIERATASL EKRGVEFLTGLPVTNVEGNVIDLKDGSKVVANTFVWTGGVQGNPLVGESGLEVNRGRA TVNDFLQSTSHEDVFVAGDSAVYFGPDGRPYPPTAQIAWQMGELIGYNLFAYLEGKTL ETFKPVNSGTLASLGRKDAVAIIGANSTPLKGLPASLMKEASNVRYLTHIKGLFSLAY *" /label="ndh CDS" gene 1245613..1246791 /gene="ndh" /locus_tag="BSU_12290" /old_locus_tag="BSU12290" /label="ndh gene" promotor_no_box 1246622..1246722 /Source="Nicolas_upshift_promotors" /id="U1007" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.59040959040959" /psig="0.015984015984016" /xcortree=1732 /SigmaFactorBS="tcaagccagtaaactctggtacacttgcaagccttggacgca aagacgcggttgccatcattggtgctaattctacaccgcttaaaggtcttcctgcttc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-10 complement(1246680..1246698) /Source="Nicolas_upshift_promotors" /id="U1008" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=506 /SigmaFactorBS="cgtacattacttgcttctttcatcaaggaaGCAGGAAGAcct ttaagcggTGTAGAATTAGCACCAATGatggcaaccgcgtctttgcgtccaaggcttg c" /listShort="S449, yjlA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1246682 /Source="Nicolas_upshifts" /id="U1007" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.59040959040959" /psig="0.015984015984016" /xcortree=1732 /SigmaFactorBS="tcaagccagtaaactctggtacacttgcaagccttggacgca aagacgcggttgccatcattggtgctaattctacaccgcttaaaggtcttcctgcttc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1246688) /Source="Nicolas_upshifts" /id="U1008" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=506 /SigmaFactorBS="cgtacattacttgcttctttcatcaaggaaGCAGGAAGAcct ttaagcggTGTAGAATTAGCACCAATGatggcaaccgcgtctttgcgtccaaggcttg c" /listShort="S449, yjlA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1246710..1246718) /Source="Nicolas_upshift_promotors" /id="U1008" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=506 /SigmaFactorBS="cgtacattacttgcttctttcatcaaggaaGCAGGAAGAcct ttaagcggTGTAGAATTAGCACCAATGatggcaaccgcgtctttgcgtccaaggcttg c" /listShort="S449, yjlA" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1246790 /Source="Nicolas_upshifts" /id="D684" /incds=0 /nref=220 /ntot=278 /MaxReadThrough="2.01042" /MaxDrop="8.69373" /score="30.6421047" /energy="-23.1" /TU="NA" /idTUdmin="U1005" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-35 1246899..1246906 /Source="Nicolas_upshift_promotors" /id="U1009" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.694305694305694" /psig="0.935064935064935" /xcortree=1573 /SigmaFactorBS="ttttcaaaaaagaGATTGATCccaaaggaatataaAGGTAAA ATAAAAACAAATCaaaatgttaacgttaacattttgaaatagaatgaaagacggtgag g" /listShort="uxaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1246921..1246940 /Source="Nicolas_upshift_promotors" /id="U1009" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.694305694305694" /psig="0.935064935064935" /xcortree=1573 /SigmaFactorBS="ttttcaaaaaagaGATTGATCccaaaggaatataaAGGTAAA ATAAAAACAAATCaaaatgttaacgttaacattttgaaatagaatgaaagacggtgag g" /listShort="uxaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1246946 /Source="Nicolas_upshifts" /id="U1009" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.694305694305694" /psig="0.935064935064935" /xcortree=1573 /SigmaFactorBS="ttttcaaaaaagaGATTGATCccaaaggaatataaAGGTAAA ATAAAAACAAATCaaaatgttaacgttaacattttgaaatagaatgaaagacggtgag g" /listShort="uxaC" /GFF_Attribute="listLong" /label="upshifts" CDS 1246989..1248410 /gene="uxaC" /locus_tag="BSU_12300" /old_locus_tag="BSU12300" /EC_number="5.3.1.12" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9579062, 9882655; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="galacturonate isomerase" /protein_id="NP_389112.1" /db_xref="EnsemblGenomes-Gn:BSU12300" /db_xref="EnsemblGenomes-Tr:CAB13087" /db_xref="GOA:O34808" /db_xref="InterPro:IPR003766" /db_xref="InterPro:IPR032466" /db_xref="SubtiList:BG13204" /db_xref="UniProtKB/Swiss-Prot:O34808" /translation="MEPFMGKNFLLKNETAVSLYHNYAKDMPIIDYHCHLSPKEIYEN KTFQNITEAWLYGDHYKWRIMRANGIEETYITGDAPDEEKFMAWAKTVPMAIGNPLYN WTHLELQRFFGIYEILNEKSGSAIWKQTNKLLKGEGFGARDLIVKSNVKVVCTTDDPV DSLEYHLLLKEDKDFPVSVLPGFRPDKGLEINREGFPEWVQALEDAAAISITTYDEFL KALEKRVRFFHSAGGRVSDHAIDTMVFAETTKEEAGRIFSDRLQGTEVSCEDEKKFKT YTLQFLCGLYAELDWAMQFHINALRNTNTKMMKRLGPDTGYDSMNDEEIAKPLYKLLN SVEMKNQLPKTILYSLNPNDNYVIASMINSFQDGITPGKIQFGTAWWFNDTKDGMLDQ MKALSNVGLFSRFIGMLTDSRSFLSYTRHEYFRRIVCNLIGEWVENGEVPRDMELLGS IVQGICYDNAKHYFQFQEEKANV*" /label="uxaC CDS" gene 1246989..1248410 /gene="uxaC" /locus_tag="BSU_12300" /old_locus_tag="BSU12300" /label="uxaC gene" CDS 1248478..1249857 /gene="exuM" /locus_tag="BSU_12310" /old_locus_tag="BSU12310" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9882655, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative Na+:altronate/mannonate symporter" /protein_id="NP_389113.1" /db_xref="EnsemblGenomes-Gn:BSU12310" /db_xref="EnsemblGenomes-Tr:CAB13088" /db_xref="GOA:O34961" /db_xref="InterPro:IPR001927" /db_xref="InterPro:IPR018043" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13205" /db_xref="UniProtKB/Swiss-Prot:O34961" /translation="MRTELANKVVSVETEKRLSLKEKMSYGFGDFGNGFMFDLGQIYL LKYFTDVAGIPAAMAGGIFLVSKLFAAITDPIVGSSIDYRKNIGKRGKFRPYLLIGSI VLAVLTVLIFLSPNVSTTGKLIYAYASYMIWGIGYSFVNIPYGSLGAAMTQNSEDRTS ISTFRQIGSLGALFITSVAVMPLLVKFDNPKVGYPVVMGLFAALGVFWFYICYRNCKE RIIISEAPKEKLTLSSVVKTFITNKPLLTLVLMTIFSISAYNIKSAMLVYFAQYNLGN VELMAYMNFIIIGSSFLGVVFLPKLVKMFGKKRTAMIGFGISVAADLINFMLPSNVYV FTILASIAFIGISIPNGITWALVSDIIDYGEWKSGERKEATTYSLFNFSRKLAQSLSG FLSGIGLGIIGYVPNAVQTAQALIGIKALLLLYPAIALALAMFIIGFLYKLTDQQHAQ IVQDLHQKS*" /label="exuM CDS" gene 1248478..1249857 /gene="exuM" /locus_tag="BSU_12310" /old_locus_tag="BSU12310" /label="exuM gene" promotor_-10 complement(1248997..1249016) /Source="Nicolas_upshift_promotors" /id="U1010" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.988011988011988" /psig="0.999000999001" /xcortree=2077 /SigmaFactorBS="cgggtagccgaccttcggattatcaAACTTGACgagcagcgg catcACGGCCACACTTGTGATAAAcaaggcgccaagtgatccgatttggcggaacgtc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1249002) /Source="Nicolas_upshifts" /id="U1010" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.988011988011988" /psig="0.999000999001" /xcortree=2077 /SigmaFactorBS="cgggtagccgaccttcggattatcaAACTTGACgagcagcgg catcACGGCCACACTTGTGATAAAcaaggcgccaagtgatccgatttggcggaacgtc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1249030..1249037) /Source="Nicolas_upshift_promotors" /id="U1010" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.988011988011988" /psig="0.999000999001" /xcortree=2077 /SigmaFactorBS="cgggtagccgaccttcggattatcaAACTTGACgagcagcgg catcACGGCCACACTTGTGATAAAcaaggcgccaagtgatccgatttggcggaacgtc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1249882 /Source="Nicolas_upshifts" /id="U1011" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.926073926073926" /psig="0.926073926073926" /xcortree=1048 /SigmaFactorBS="gctcagatcgttcaggatcttcatcaaaagagctgacaatat aatataaagaatatttaaaataatttgtAAATAAAAtgtgtttgtaggggtttcgctt g" /listShort="S452, yjmC, yjmD, uxuA, uxuB, exuT, exuR" /GFF_Attribute="listLong" /label="upshifts" misc_feature 1249892..1249899 /Source="Nicolas_upshift_promotors" /id="U1011" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.926073926073926" /psig="0.926073926073926" /xcortree=1048 /SigmaFactorBS="gctcagatcgttcaggatcttcatcaaaagagctgacaatat aatataaagaatatttaaaataatttgtAAATAAAAtgtgtttgtaggggtttcgctt g" /listShort="S452, yjmC, yjmD, uxuA, uxuB, exuT, exuR" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 1249894..1249961 /Source="Nicolas_S_feature" /locus_tag="new_1303355_1303422" /HighExp="S4, S5, S6, S3, S8, S7, T5.0H, T4.0H, T3.30H, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.926" /TUlongSig="NA" /TUlongPSig="NA" /label="S452" CDS 1249962..1250975 /gene="yjmC" /locus_tag="BSU_12320" /old_locus_tag="BSU12320" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9579062, 9882655, 16788182; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_389114.1" /db_xref="EnsemblGenomes-Gn:BSU12320" /db_xref="EnsemblGenomes-Tr:CAB13089" /db_xref="GOA:O34736" /db_xref="InterPro:IPR003767" /db_xref="InterPro:IPR036111" /db_xref="SubtiList:BG13206" /db_xref="UniProtKB/Swiss-Prot:O34736" /translation="MKTITIAAEEAKELVWQKLDGAGLNERDAEKVADVLVHADLRNV HSHGVLHTEHYVNRLLAGGINPGAQPVFKETGPVTGVLDGDDGFGHVNCDMAMDHAID MAKKKGVGMVTAVNSSHCGALSYFVQKAADEKLIGMAMTHTDSIVVPFGGRTPILGTN PIAYGVPAKHKKPFILDMATSKVAFGKILQAREEGKEIPEGWGVDENGEAVTDPDKVV SLSTFGGPKGYGLSIVVDVFSGLLAGAAFGPHIAKMYNGLDQKRKLGHYVCAINPSFF TDWDTFLEQMDAMIDELQQSPPAVGFERVYVPGEIEQLHEERNKKNGISIARSVYEFL KSR*" /label="yjmC CDS" gene 1249962..1250975 /gene="yjmC" /locus_tag="BSU_12320" /old_locus_tag="BSU12320" /label="yjmC gene" CDS 1250981..1252000 /gene="yjmD" /locus_tag="BSU_12330" /old_locus_tag="BSU12330" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9579062, 9882655; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_389115.1" /db_xref="EnsemblGenomes-Gn:BSU12330" /db_xref="EnsemblGenomes-Tr:CAB13090" /db_xref="GOA:O35045" /db_xref="InterPro:IPR002328" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR020843" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13207" /db_xref="UniProtKB/Swiss-Prot:O35045" /translation="MKAVQVRKAYDLVTAEVKKPVLSKDDEVLVKVKRVGICGSDMHI YHGTNPLATLPRVIGHEVTGQVEAVGANVQSLKPGDHVVIEPISYCGSCYACRKGRPN VCAKLSVFGVHEDGGMREYIVLPERQLHAVSKDLPWEEAVMAEPYTIGAQAVWRGQVE KGDTVLIQGAGPIGICVLKMAKLAGAAVMMTDLNNERLAFAKENGADAVVNVQAEHVA ERVLEWTGNEGANVVIDAVCLPETFALSIEAVSPAGHVVVLGFDERAAQISQLPITKK EVTITGSRLQTNQFPKVVELLNGGRLMHNGLVTHTFSVDDVHHAFQFIKEHPDQVRKA VITFD*" /label="yjmD CDS" gene 1250981..1252000 /gene="yjmD" /locus_tag="BSU_12330" /old_locus_tag="BSU12330" /label="yjmD gene" CDS 1252025..1253104 /gene="uxuA" /locus_tag="BSU_12340" /old_locus_tag="BSU12340" /EC_number="4.2.1.8" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 9579062, 9882655, 10368143, 25145794; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-mannonate dehydratase" /protein_id="NP_389116.1" /db_xref="EnsemblGenomes-Gn:BSU12340" /db_xref="EnsemblGenomes-Tr:CAB13091" /db_xref="GOA:O34346" /db_xref="InterPro:IPR004628" /db_xref="InterPro:IPR036237" /db_xref="SubtiList:BG13208" /db_xref="UniProtKB/Swiss-Prot:O34346" /translation="MNMTFRWYGRGNDTVTLEYVKQIPGVKGIVWALHQKPVGDVWEK EEIRAETEYIQSYGFHAEVVESVNVHEAIKLGNEERGRYIENYKQTIRNLAGFGVKVI CYNFMPVFDWTRTDMFRPLEDGSTALFFEKAKVESLDPQELIRTVEEASDMTLPGWEP EKLARIKELFAAYRTVDEEKLWDNLSFFLQEILPVAEAYGVQMAIHPDDPPWPIFGLP RIITGEASYKKLRAISDSPSNCITLCTGSMGANPANDMVEIAKTYAGIAPFSHIRNVK IYENGDFIETSHLTKDGSINIQGVMEELHKQDYEGYVRPDHGRHLWGEQCRPGYGLYD RALGIMYLNGLWDAYEAMAKKEVGI*" /label="uxuA CDS" gene 1252025..1253104 /gene="uxuA" /locus_tag="BSU_12340" /old_locus_tag="BSU12340" /label="uxuA gene" CDS 1253101..1253937 /gene="uxuB" /locus_tag="BSU_12350" /old_locus_tag="BSU12350" /EC_number="1.1.1.57" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9579062, 9882655, 10368143; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fructuronate reductase" /protein_id="NP_389117.1" /db_xref="EnsemblGenomes-Gn:BSU12350" /db_xref="EnsemblGenomes-Tr:CAB13092" /db_xref="GOA:O34896" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13209" /db_xref="UniProtKB/Swiss-Prot:O34896" /translation="MIPLHENLAGKTAVITGGSGVLCSAMARELARHGMKVAILNRTA EKGQAVVKEITAAGGTACAVAADVLDRMSLERAKEDILGQFGAVDLLINGAGGNHPDA ITDVETYEEAGEGQSFFDMDERGFLTVFSTNFTGAFLASQVFGKELLKADSPAIINLS SMSAYSPMTKVPAYSAAKASINNFTMWMAVHFAETGLRVNAIAPGFFLTKQNHDLLIN QDGTFTSRSHKIIAGTPMKRFGKPEDLLGTLLWLADESYSGFVTGITVPVDGGFMAYS GV*" /label="uxuB CDS" gene 1253101..1253937 /gene="uxuB" /locus_tag="BSU_12350" /old_locus_tag="BSU12350" /label="uxuB gene" CDS 1253985..1255253 /gene="exuT" /locus_tag="BSU_12360" /old_locus_tag="BSU12360" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8320243, 9579062, 9882655, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="hexuronate transporter" /protein_id="NP_389118.1" /db_xref="EnsemblGenomes-Gn:BSU12360" /db_xref="EnsemblGenomes-Tr:CAB13093" /db_xref="GOA:O34456" /db_xref="InterPro:IPR000849" /db_xref="InterPro:IPR004744" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13210" /db_xref="UniProtKB/Swiss-Prot:O34456" /translation="MFSKDKLPVILFLFLAGVINYLDRSALSIAAPFIQDDLTLSATQ MGLIFSSFSIGYAIFNFLGGVASDRYGAKLTLFVAMVVWSLFSGAVALAFGFVSLLII RILFGMGEGPLSATINKMVNNWFPPTQRASVIGVTNSGTPLGGAISGPIVGMIAVAFS WKVSFVLIMIIGLIWAVLWFKFVKEKPQETIKEAPAIKAETSPGEKIPLTFYLKQKTV LFTAFAFFAYNYILFFFLTWFPSYLVDERGLSVESMSVITVIPWILGFIGLAAGGFVS DYVYKKTARKGVLFSRKVVLVTCLFSSAVLIGFAGLVATTAGAVTLVALSVFFLYLTG AIYWAVIQDVVDQNNVGSVGGFMHFLANTAGIIGPALTGFIVDQTGTFSGAFLLAGGL AVFASLAVIRFVRPIIGKPAGTEAENPVSY*" /label="exuT CDS" gene 1253985..1255253 /gene="exuT" /locus_tag="BSU_12360" /old_locus_tag="BSU12360" /label="exuT gene" promotor_-35 1255197..1255200 /Source="Nicolas_upshift_promotors" /id="U1012" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.637362637362637" /psig="0.005994005994006" /xcortree=1486 /SigmaFactorBS="ctggctgtcttcgcttcacttgctgtgattcgttttgtcCGT CcaatcattggtaagcCAGCGggaacagaagctgagaatcctgtgtcttattaatctg g" /listShort="exuR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1255216..1255220 /Source="Nicolas_upshift_promotors" /id="U1012" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.637362637362637" /psig="0.005994005994006" /xcortree=1486 /SigmaFactorBS="ctggctgtcttcgcttcacttgctgtgattcgttttgtcCGT CcaatcattggtaagcCAGCGggaacagaagctgagaatcctgtgtcttattaatctg g" /listShort="exuR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1255218 /Source="Nicolas_upshifts" /id="U1012" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.637362637362637" /psig="0.005994005994006" /xcortree=1486 /SigmaFactorBS="ctggctgtcttcgcttcacttgctgtgattcgttttgtcCGT CcaatcattggtaagcCAGCGggaacagaagctgagaatcctgtgtcttattaatctg g" /listShort="exuR" /GFF_Attribute="listLong" /label="upshifts" misc_feature 1255286..1255305 /Source="Nicolas_upshift_promotors" /id="U1013" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.966033966033966" /psig=1 /xcortree=3107 /SigmaFactorBS="agaagctgagaatcctgtgtcttattaatctggaaatatagt gggagaggcggtatgtttGATGATACAATATACAGTAAataatcgcagccggtatgat a" /listShort="exuR" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1255286 /Source="Nicolas_upshifts" /id="U1013" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.966033966033966" /psig=1 /xcortree=3107 /SigmaFactorBS="agaagctgagaatcctgtgtcttattaatctggaaatatagt gggagaggcggtatgtttGATGATACAATATACAGTAAataatcgcagccggtatgat a" /listShort="exuR" /GFF_Attribute="listLong" /label="upshifts" CDS 1255341..1256342 /gene="exuR" /locus_tag="BSU_12370" /old_locus_tag="BSU12370" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9579062, 9882655" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9579062, 9882655; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (LacI family)" /protein_id="NP_389119.1" /db_xref="EnsemblGenomes-Gn:BSU12370" /db_xref="EnsemblGenomes-Tr:CAB13094" /db_xref="GOA:Q9JMQ1" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG13211" /db_xref="UniProtKB/Swiss-Prot:Q9JMQ1" /translation="MVTIKDIAKLANVSHTTVSRALNNSPYIKEHTKKKILELAEQLN YTPNVNAKSLAMQKSHTIGLFFTSITNGTSHSFFADTIKGVNQAISEDYNLYVRGIDD LKNYDSVTPMRYDGIILMSQSDIDNSFIYHIREKNIPLVVLNRDIDDRTITNILSNDK EGSQEAVEYFIQSGHQDIAIIEGIEGFKSSQQRKEGYLSALIQHHIPIKHEYSVKGQY DMESGFQAMERLLALPNPPTAVFCSNDDMAIGAMNAIFAKGLRVPDDISVIGFDDIGF SQYITPRLSTVKRPVEKISVLGAQKLLSLISEPETKAEKILENTEFMVRDSVRRLTT* " /label="exuR CDS" gene 1255341..1256342 /gene="exuR" /locus_tag="BSU_12370" /old_locus_tag="BSU12370" /label="exuR gene" promotor_no_box complement(1256024..1256124) /Source="Nicolas_upshift_promotors" /id="U1014" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.915084915084915" /psig="0.024975024975025" /xcortree=19 /SigmaFactorBS="cgcgcaggccctttgcgaatatcgcattcatcgctccgattg ccatgtcatcattcgaacaaaaaacagcggttggaggattcggcagtgccagcagccg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1256064) /Source="Nicolas_upshifts" /id="U1014" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.915084915084915" /psig="0.024975024975025" /xcortree=19 /SigmaFactorBS="cgcgcaggccctttgcgaatatcgcattcatcgctccgattg ccatgtcatcattcgaacaaaaaacagcggttggaggattcggcagtgccagcagccg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1256318 /Source="Nicolas_upshifts" /id="D685" /incds=0 /nref=2 /ntot=132 /MaxReadThrough="2.47166" /MaxDrop="3.11543" /score="12.2153519" /energy="-7.4" /TU="NA" /idTUdmin="U1011" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 1256419..1257861 /gene="uxaB" /locus_tag="BSU_12380" /old_locus_tag="BSU12380" /EC_number="1.1.1.58" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9579062, 9882655; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tagaturonate reductase (altronate oxidoreductase)" /protein_id="NP_389120.1" /db_xref="EnsemblGenomes-Gn:BSU12380" /db_xref="EnsemblGenomes-Tr:CAB13095" /db_xref="GOA:O34354" /db_xref="InterPro:IPR000669" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013118" /db_xref="InterPro:IPR013131" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR023668" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13212" /db_xref="UniProtKB/Swiss-Prot:O34354" /translation="MQKLNKNVYDHYTQYPEKILQFGEGNFLRGFIDWQIDQLNQHTD FNGSVAVVQPRGSEKIKRLNEQDGLYTLFLQGMKDGEAVNEHMIINSISRGIDLFSDY EAYKELASSERLRFIISNTTEAGIVCDEKDRLEDRPQKTFPGKLTAFLYFRYQAFKGD QTKGCVLIPCELIENNGEKLRETVLHYAHLWKLEEGFTQWIHEANTFCNSLVDRIVPG FPVDSIDEITADLGYQDDLIVVGEQYYLWVIEGPDWIGKELPFAAAGLHTKIVSDLTP YRTKKVRILNGAHTAMTPVALLYGLKTVRDAVEHPEVGRFIRELIDDEILPVLKMEGL SQYADDVLNRFKNPYIKHYLESIALNAISKFKTRNLPTLKEYAEQKGQLPERLVFSFS ALLYFYHDNETLQDDPAVLQFFKEVWCQEDGDMLRIASRVLGEQRLWGADLNEIPKLT DRVAVYLNHIHELGMQRALEQYCIQGGEVR*" /label="uxaB CDS" gene 1256419..1257861 /gene="uxaB" /locus_tag="BSU_12380" /old_locus_tag="BSU12380" /label="uxaB gene" CDS 1257858..1259351 /gene="uxaA" /locus_tag="BSU_12390" /old_locus_tag="BSU12390" /EC_number="4.2.1.7" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9579062, 9882655; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="altronate dehydratase" /protein_id="NP_389121.2" /db_xref="EnsemblGenomes-Gn:BSU12390" /db_xref="EnsemblGenomes-Tr:CAB13096" /db_xref="GOA:O34673" /db_xref="InterPro:IPR007392" /db_xref="InterPro:IPR013974" /db_xref="SubtiList:BG13213" /db_xref="UniProtKB/Swiss-Prot:O34673" /translation="MKSFIKIHKQDNVLLALRDIQKGERLHAYGVSIEVKDDIKRGHK IALQSIKENDSIVKYGFPIGHASQDISIGEHIHVHNTKTNLSDIQLYSYTPRFDENPY SNENRTFKGFRRENGDAGVRNELWIVPTVGCVNGIAEKMLQRFVRETGDIAPFDNVLV LKHQYGCSQLGDDHENTKQILLNAIRHPNAGGVLVLGLGCENNELARMKEALQDVNLK RVKFLESQSVTDEMEAGVALLKEIHEAAKGDKREDIPLSELKIGLKCGGSDGFSGITA NPLLGRFSDYLIAQGGSTVLTEVPEMFGAETILMQRAANEEVFHKIVDLINDFKQYFI KHDQPVYENPSPGNKAGGISTLEDKSLGCTQKAGISPVTDVLKYGEVLKTKGLTLLSA PGNDLIASSALAAAGCQIVLFTTGRGTPFGTFVPTVKVATNTELYEAKPHWIDFNAGL LAEDDVHEEYVLREFIHYMIEVASGQLVNHEKNDFKELAIFKSGVTL*" /label="uxaA CDS" gene 1257858..1259351 /gene="uxaA" /locus_tag="BSU_12390" /old_locus_tag="BSU12390" /label="uxaA gene" CDS complement(1259390..1260154) /gene="yjnA" /locus_tag="Delta6_BSU_12400_SNPvariant" /old_locus_tag="BSU_12400" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 16885442; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_389122.1" /db_xref="EnsemblGenomes-Gn:BSU12400" /db_xref="EnsemblGenomes-Tr:CAB13097" /db_xref="GOA:O34578" /db_xref="InterPro:IPR002781" /db_xref="SubtiList:BG13214" /db_xref="UniProtKB/Swiss-Prot:O34578" /modified_by="User" /translation="MSVSIILMGLFVGALVGLTGVGGAALLTPLLIVLGINPSIAVGT DLVYNSITKLFGVASHWRQKTINFKLVKYLAIGGIPSASLAIGILHLFPAFHQHQEEI IKHALGYVLTLVAISIIVRLFLDRKLRPNRWQLMPLENKRALTILIGVVFGFIVGLTS IGSGSLFAIAMIYLFNMKASQIVGTDIAHAFLLVTAAGILNASFGSVDYMLAANLLLG SIPGVLIGSHLSPRFSPRPLQFIMASIILVSGLKLI*" /label="Delta6_BSU_12400_SNPvariant" gene complement(1259390..1260154) /gene="yjnA" /locus_tag="Delta6_BSU_12400_SNPvariant" /old_locus_tag="BSU_12400" /modified_by="User" /label="Delta6_BSU_12400_SNPvariant" downshifts complement(1259409) /Source="Nicolas_upshifts" /id="D686" /incds=0 /nref=96 /ntot=170 /MaxReadThrough="1.34004" /MaxDrop="4.60564" /score="6.47747687" /energy="-11.3" /TU="NA" /idTUdmin="U1015" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" Polymorphism join(1259922,1259924) /Source="geneious" /ID="SNP_BsDelta6_1313384_1313384" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change="S -> G" /CDS_Position=232 /Change="T -> C" /Codon_Change="AGT -> GGT" /Coverage=150 /locus_tag="BSU_12400" /Protein_Effect="Substitution" /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides="C" /Variant_P_Value=0 /Variant_Raw_Frequency=149 /comment="Delta6_BSU_12400_SNPvariant" /modified_by="User" / /label="Polymorphism_Delta6" SCAR join(1260181,1260188) /created_by="User" /modified_by="User" /label="TF8A" N_region 1260182..1260187 /created_by="User" /note_="EcoRI site (GAATTC)" /modified_by="User" /label="TF8A" CDS <1260190..1260510 /gene="xlyA" /locus_tag="Delta6_pseudo_BSU_12810" /old_locus_tag="BSU12810" /EC_number="3.5.1.28" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:7921239, 9555893" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7921239, 9555893; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="phage PBSX; N-acetylmuramoyl-L-alanine amidase" /protein_id="NP_389164.1" /db_xref="EnsemblGenomes-Gn:BSU12810" /db_xref="EnsemblGenomes-Tr:CAB13138" /db_xref="GOA:P39800" /db_xref="InterPro:IPR002477" /db_xref="InterPro:IPR002502" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036365" /db_xref="InterPro:IPR036366" /db_xref="InterPro:IPR036505" /db_xref="InterPro:IPR036779" /db_xref="PDB:3HMB" /db_xref="PDB:3RDR" /db_xref="SubtiList:BG10962" /db_xref="UniProtKB/Swiss-Prot:P39800" /NCBI_locus_tag="A8O17_RS06625" /modified_by="User" /translation="PNLIRVGQVLIVSAPSAAEKPELYPLPDGIIQLTTPYTSGEHVF QVQRALAALYFYPDKGAVNNGIDGVYGPKTADAVARFQSVNGLTADGIYGPATKEKIA AQLS*" /label="Delta6_pseudo_BSU_12810" gene <1260190..1260510 /gene="xlyA" /locus_tag="Delta6_pseudo_BSU_12810" /old_locus_tag="BSU12810" /NCBI_locus_tag="A8O17_RS06625" /modified_by="User" /label="Delta6_pseudo_BSU_12810" downshifts 1260519 /Source="Nicolas_upshifts" /id="D696" /incds=0 /nref=29 /ntot=162 /MaxReadThrough="3.77255" /MaxDrop="5.00305" /score="30.9009227" /energy="-12.5" /TU="U1029,U1033" /idTUdmin="U1029" /TUdmin="-152" /isTUend="FALSE" /label="downshifts" S_feature complement(1260528..1260731) /Source="Nicolas_S_feature" /locus_tag="new_1348200_1348403_c" /HighExp="S8, S6, S7, BT, B36, S5, S4, G/S, Pyr, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="1, 0.798" /TUlongSig="NA" /TUlongPSig="NA" /label="S458" CDS complement(1260547..1260684) /gene="spoIISC" /locus_tag="BSU_12815" /old_locus_tag="BSU12815" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11371520, 18096016, 20863891, 21147767, 25039482, 26300872, 27294956; Product type r: regulator" /codon_start=1 /transl_table=11 /product="three component toxin / antitoxin / antitoxin SpoIISABC, antitoxin C" /protein_id="YP_009513952.1" /translation="MSGDTVKKLVRRVKFVDYGRFGLSGYSLRVRERSAGIIKKLKKK K*" /label="spoIISC CDS" gene complement(1260547..1260684) /gene="spoIISC" /locus_tag="BSU_12815" /old_locus_tag="BSU12815" /label="spoIISC gene" downshifts complement(1260571) /Source="Nicolas_upshifts" /id="D697" /incds=0 /nref=31 /ntot=215 /MaxReadThrough="2.75573" /MaxDrop="4.3776" /score="24.0186344" /energy="-12.5" /TU="U1034" /idTUdmin="U1035" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1260770..1260940) /gene="spoIISB" /locus_tag="BSU_12820" /old_locus_tag="BSU12820" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11371520, 18096016, 20863891, 21147767, 25039482, 26300872, 27294956" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11371520, 18096016, 20863891, 21147767, 25039482, 26300872, 27294956; Product type f: factor" /codon_start=1 /transl_table=11 /product="three-component apoptotic control system component B (antitoxin B)" /protein_id="NP_389165.1" /db_xref="EnsemblGenomes-Gn:BSU12820" /db_xref="EnsemblGenomes-Tr:CAB13139" /db_xref="GOA:O34800" /db_xref="InterPro:IPR025897" /db_xref="PDB:3O6Q" /db_xref="SubtiList:BG12678" /db_xref="UniProtKB/Swiss-Prot:O34800" /translation="MERAFQNRCEPRAAKPFKILKKRSTTSVASYQVSPHTARIFKEN ERLIDEYKRKKA*" /label="spoIISB CDS" gene complement(1260770..1260940) /gene="spoIISB" /locus_tag="BSU_12820" /old_locus_tag="BSU12820" /label="spoIISB gene" downshifts complement(1260776) /Source="Nicolas_upshifts" /id="D698" /incds=0 /nref=6 /ntot=86 /MaxReadThrough="4.69899" /MaxDrop="3.0872" /score="24.0186344" /energy="-12.5" /TU="U1034,U1035" /idTUdmin="U1035" /TUdmin="-205" /isTUend="FALSE" /label="downshifts" CDS complement(1260940..1261686) /gene="spoIISA" /locus_tag="BSU_12830" /old_locus_tag="BSU12830" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11371520, 18096016, 20863891, 21147767, 25039482, 26300872, 27294956" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11371520, 18096016, 20863891, 21147767, 25039482, 26300872, 27294956; Product type f: factor" /codon_start=1 /transl_table=11 /product="three-component apoptosis factor (ABC toxin/antitoxin/antitoxin system)" /protein_id="NP_389166.1" /db_xref="EnsemblGenomes-Gn:BSU12830" /db_xref="EnsemblGenomes-Tr:CAB13140" /db_xref="GOA:O34853" /db_xref="InterPro:IPR025940" /db_xref="PDB:3O6Q" /db_xref="SubtiList:BG12677" /db_xref="UniProtKB/Swiss-Prot:O34853" /translation="MVLFFQIMVWCIVAGLGLYVYATWRFEAKVKEKMSAIRKTWYLL FVLGAMVYWTYEPTSLFTHWERYLIVAVSFALIDAFIFLSAYVKKLAGSELETDTREI LEENNEMLHMYLNRLKTYQYLLKNEPIHVYYGSIDAYAEGIDKLLKTYADKMNLTASL CHYSTQADKDRLTEHMDDPADVQTRLDRKDVYYDQYGKVVLIPFTIETQNYVIKLTSD SIVTEFDYLLFTSLTSIYDLVLPIEEEGEG*" /label="spoIISA CDS" gene complement(1260940..1261686) /gene="spoIISA" /locus_tag="BSU_12830" /old_locus_tag="BSU12830" /label="spoIISA gene" promotor_-10 complement(1261521..1261540) /Source="Nicolas_upshift_promotors" /id="U1034" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.724275724275724" /psig=1 /xcortree=623 /SigmaFactorBS="tcaaagaaaaaatgtccgccattcggaaaacttggTATTTGC TgtttgttctgggcgcTATGGTATACTGGACATATGagcccacttccctatttaccca c" /listShort="spoIISB, S458" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1261538) /Source="Nicolas_upshifts" /id="U1034" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.724275724275724" /psig=1 /xcortree=623 /SigmaFactorBS="tcaaagaaaaaatgtccgccattcggaaaacttggTATTTGC TgtttgttctgggcgcTATGGTATACTGGACATATGagcccacttccctatttaccca c" /listShort="spoIISB, S458" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1261556..1261563) /Source="Nicolas_upshift_promotors" /id="U1034" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.724275724275724" /psig=1 /xcortree=623 /SigmaFactorBS="tcaaagaaaaaatgtccgccattcggaaaacttggTATTTGC TgtttgttctgggcgcTATGGTATACTGGACATATGagcccacttccctatttaccca c" /listShort="spoIISB, S458" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1261712..1261730) /Source="Nicolas_upshift_promotors" /id="U1035" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.798201798201798" /psig="0.798201798201798" /xcortree=1112 /SigmaFactorBS="cttctgtcaaaggagcggtttttttgatggaacaGGAAAAcc atccggatctctcGAATACAATAAGCAGAACCtatttcagatgtgagggattcgaata t" /listShort="spoIISA, spoIISB, S458" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1261725) /Source="Nicolas_upshifts" /id="U1035" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.798201798201798" /psig="0.798201798201798" /xcortree=1112 /SigmaFactorBS="cttctgtcaaaggagcggtttttttgatggaacaGGAAAAcc atccggatctctcGAATACAATAAGCAGAACCtatttcagatgtgagggattcgaata t" /listShort="spoIISA, spoIISB, S458" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1261746..1261751) /Source="Nicolas_upshift_promotors" /id="U1035" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.798201798201798" /psig="0.798201798201798" /xcortree=1112 /SigmaFactorBS="cttctgtcaaaggagcggtttttttgatggaacaGGAAAAcc atccggatctctcGAATACAATAAGCAGAACCtatttcagatgtgagggattcgaata t" /listShort="spoIISA, spoIISB, S458" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1261796..1262797) /gene="pitB" /locus_tag="BSU_12840" /old_locus_tag="BSU12840" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 10784039, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative low-affinity inorganic phosphate transporter" /protein_id="NP_389167.2" /db_xref="EnsemblGenomes-Gn:BSU12840" /db_xref="EnsemblGenomes-Tr:CAB13141" /db_xref="GOA:O34436" /db_xref="InterPro:IPR001204" /db_xref="SubtiList:BG13226" /db_xref="UniProtKB/Swiss-Prot:O34436" /translation="MDILLILTILIVICALAFDFINGFHDTANAIATSVSTKALKPRH AIILAAVMNFVGAMTFTGVAKTITKDIVDPYTLENGSVVILAALLAAIAWNLITWYYG IPSSSSHAIIGAIAGAAIAAAGFAALNYKGFIKIIEALILSPIIAFVLGFILYSIVKL IFKDSNLAKTNKQFRRVQIVTAALQSYTHGTNDAQKAMGIITMALITANLHTSANDIP TWVQFACATAMGLGTSIGGWKIIKTVGGKIMKIRPVNGVSADLTGAAIIFGATFIHLP VSTTHVISSSILGVGASHRVKGVNWGTAKRMLITWVITLPISATLGAIAYFILNMIF* " /label="pitB CDS" gene complement(1261796..1262797) /gene="pitB" /locus_tag="BSU_12840" /old_locus_tag="BSU12840" /label="pitB gene" downshifts complement(1261825) /Source="Nicolas_upshifts" /id="D699" /incds=0 /nref=205 /ntot=253 /MaxReadThrough="3.49591" /MaxDrop="5.81942" /score="21.8061263" /energy="-11" /TU="U1036,U1038" /idTUdmin="U1037" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1262810..1263427) /gene="ykaA" /locus_tag="BSU_12850" /old_locus_tag="BSU12850" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9696772, 14563871; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative PitB transporter accessory protein" /protein_id="NP_389168.1" /db_xref="EnsemblGenomes-Gn:BSU12850" /db_xref="EnsemblGenomes-Tr:CAB13142" /db_xref="InterPro:IPR018445" /db_xref="SubtiList:BG13225" /db_xref="UniProtKB/Swiss-Prot:O34454" /translation="MIRRKKDKFSLLLTEIAKNIDETAEYFVNFKVTNQTTLKEFADT LKEYETKGDNHVHVMIKELNKAFITPIEREDILQLTNSLDDVLDGIEHFSAMMEIFSI TSSDEHIDKFSGYIRECAKEILITIELLAENRLKDIQPHAIKIKEYEHSCDNLHRKSL KNLFGNETDPIKVIQYREIYETLEEIADSCQSVANNLETIIMKNA*" /label="ykaA CDS" gene complement(1262810..1263427) /gene="ykaA" /locus_tag="BSU_12850" /old_locus_tag="BSU12850" /label="ykaA gene" promotor_-10 complement(1263463..1263482) /Source="Nicolas_upshift_promotors" /id="U1036" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig="0.996003996003996" /xcortree=2607 /SigmaFactorBS="aagatacgtttttttcgactttaCCTGTtttttttcgacaaa aGGCTATATAATAATTTGATGtgtgcattgttcattcaaactatggagggtttttaat g" /listShort="ykaA, pit" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1263465) /Source="Nicolas_upshifts" /id="U1036" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig="0.996003996003996" /xcortree=2607 /SigmaFactorBS="aagatacgtttttttcgactttaCCTGTtttttttcgacaaa aGGCTATATAATAATTTGATGtgtgcattgttcattcaaactatggagggtttttaat g" /listShort="ykaA, pit" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1263467..1263564) /Source="Nicolas_S_feature" /locus_tag="new_1351139_1351236_c" /HighExp="H2O2, Etha, dia15, Diami, Paraq, Heat, dia5, Salt, LBGstat, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.972, 0.987" /TUlongSig="SigA" /TUlongPSig="0.992" /label="S459" promotor_-35 complement(1263498..1263502) /Source="Nicolas_upshift_promotors" /id="U1036" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig="0.996003996003996" /xcortree=2607 /SigmaFactorBS="aagatacgtttttttcgactttaCCTGTtttttttcgacaaa aGGCTATATAATAATTTGATGtgtgcattgttcattcaaactatggagggtttttaat g" /listShort="ykaA, pit" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1263544..1263563) /Source="Nicolas_upshift_promotors" /id="U1037" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig="0.972027972027972" /xcortree=641 /SigmaFactorBS="atatactttttacgttaagcagaaagtttttgcaaacttGGG TCGTTtttttaaagcgaagTAGGTCAAAATAAGGAGACAcgatttatcaaaaaagtca a" /listShort="S459, ykaA, pit" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1263564) /Source="Nicolas_upshifts" /id="U1037" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig="0.972027972027972" /xcortree=641 /SigmaFactorBS="atatactttttacgttaagcagaaagtttttgcaaacttGGG TCGTTtttttaaagcgaagTAGGTCAAAATAAGGAGACAcgatttatcaaaaaagtca a" /listShort="S459, ykaA, pit" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1263578..1263585) /Source="Nicolas_upshift_promotors" /id="U1037" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig="0.972027972027972" /xcortree=641 /SigmaFactorBS="atatactttttacgttaagcagaaagtttttgcaaacttGGG TCGTTtttttaaagcgaagTAGGTCAAAATAAGGAGACAcgatttatcaaaaaagtca a" /listShort="S459, ykaA, pit" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(1263609..1263628) /Source="Nicolas_upshift_promotors" /id="U1038" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.677322677322677" /psig="0.987012987012987" /xcortree=1829 /SigmaFactorBS="ggaaccgttttttggtgaaacagaagataaaagttgacagga aaaacacaactTTTGATATACTTTTTACGTTaagcagaaagtttttgcaaacttgggt c" /listShort="S459, ykaA, pit" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1263621) /Source="Nicolas_upshifts" /id="U1038" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.677322677322677" /psig="0.987012987012987" /xcortree=1829 /SigmaFactorBS="ggaaccgttttttggtgaaacagaagataaaagttgacagga aaaacacaactTTTGATATACTTTTTACGTTaagcagaaagtttttgcaaacttgggt c" /listShort="S459, ykaA, pit" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1263703..1265019) /gene="steT" /locus_tag="BSU_12860" /old_locus_tag="BSU12860" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 17344220, 19419962, 20610400" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 17344220, 19419962, 20610400; Product type t : transporter" /codon_start=1 /transl_table=11 /product="serine / threonine exchanger" /protein_id="NP_389169.1" /db_xref="EnsemblGenomes-Gn:BSU12860" /db_xref="EnsemblGenomes-Tr:CAB13143" /db_xref="GOA:O34739" /db_xref="InterPro:IPR002293" /db_xref="SubtiList:BG13227" /db_xref="UniProtKB/Swiss-Prot:O34739" /translation="MHTEDNGLKKEIGLLFALTLVIGTIIGSGVFMKPGAVLAYSGDS KMALFAWLLGGILTLAGGLTIAEIGTQIPKTGGLYTYLEEVYGEFWGFLCGWVQIIIY GPAIIGALGLYFGSLMANLFGWGSGLSKVIGIIAVLFLCVINIIGTKYGGFVQTLTTI GKLIPIACIIVFGLWKGDQHIFTAVNESISDMNFGAAILATLFAYDGWILLAALGGEM KNPEKLLPRAMTGGLLIVTAIYIFINFALLHILSANEIVTLGENATSTAATMLFGSIG GKLISVGIIVSIFGCLNGKVLSFPRVSFAMAERKQLPFAEKLSHVHPSFRTPWIAISF QIALALIMMLISNPDKLSEISIFMIYIFYVMAFFAVFILRKRAKGEKRAYSVPLYPFM PILAIAGSFFVLGSTLITDTMSCGLSILIGLAGLPVYYGMKKRKAS*" /label="steT CDS" gene complement(1263703..1265019) /gene="steT" /locus_tag="BSU_12860" /old_locus_tag="BSU12860" /label="steT gene" downshifts complement(1263718) /Source="Nicolas_upshifts" /id="D700" /incds=0 /nref=3 /ntot=92 /MaxReadThrough="3.59461" /MaxDrop="3.97157" /score="23.3119204" /energy="-14.4" /TU="U1039" /idTUdmin="U1039" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1265066..1265085) /Source="Nicolas_upshift_promotors" /id="U1039" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.633366633366633" /psig="0.992007992007992" /xcortree=2632 /SigmaFactorBS="gtacacaaagcaaatttcgaaaatcagaaaatttattttATT TcacttttctaaaatAGGGTTTACAATATGAAAAAatagattcttcaacatgaagctt c" /listShort="ykbA" /listLong="S459, ykaA, pit" /label="promotor_-10" upshifts complement(1265082) /Source="Nicolas_upshifts" /id="U1039" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.633366633366633" /psig="0.992007992007992" /xcortree=2632 /SigmaFactorBS="gtacacaaagcaaatttcgaaaatcagaaaatttattttATT TcacttttctaaaatAGGGTTTACAATATGAAAAAatagattcttcaacatgaagctt c" /listShort="ykbA" /listLong="S459, ykaA, pit" /label="upshifts" promotor_-35 complement(1265100..1265103) /Source="Nicolas_upshift_promotors" /id="U1039" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.633366633366633" /psig="0.992007992007992" /xcortree=2632 /SigmaFactorBS="gtacacaaagcaaatttcgaaaatcagaaaatttattttATT TcacttttctaaaatAGGGTTTACAATATGAAAAAatagattcttcaacatgaagctt c" /listShort="ykbA" /listLong="S459, ykaA, pit" /label="promotor_-35" promotor_-35 1265302..1265309 /Source="Nicolas_upshift_promotors" /id="U1040" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.774225774225774" /psig="0.964035964035964" /xcortree=632 /SigmaFactorBS="tgaacgaaccttcggtgaagctgataTGTTGACTttctcatg cgaataAAATACTTTGTTATTAGAACaataaatatacaattatgatatgatatctcga a" /listShort="S460, mhqA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1265324..1265343 /Source="Nicolas_upshift_promotors" /id="U1040" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.774225774225774" /psig="0.964035964035964" /xcortree=632 /SigmaFactorBS="tgaacgaaccttcggtgaagctgataTGTTGACTttctcatg cgaataAAATACTTTGTTATTAGAACaataaatatacaattatgatatgatatctcga a" /listShort="S460, mhqA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1265336..1265407 /Source="Nicolas_S_feature" /locus_tag="new_1353008_1353079" /HighExp="Etha, dia15, Salt, Heat, dia5, Diami, H2O2, M9-stat, MG 25, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.964" /TUlongSig="NA" /TUlongPSig="NA" /label="S460" upshifts 1265336 /Source="Nicolas_upshifts" /id="U1040" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.774225774225774" /psig="0.964035964035964" /xcortree=632 /SigmaFactorBS="tgaacgaaccttcggtgaagctgataTGTTGACTttctcatg cgaataAAATACTTTGTTATTAGAACaataaatatacaattatgatatgatatctcga a" /listShort="S460, mhqA" /GFF_Attribute="listLong" /label="upshifts" CDS 1265408..1266358 /gene="mhqA" /locus_tag="BSU_12870" /old_locus_tag="BSU12870" /EC_number="1.13.11.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:17407181, 17725564" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17407181, 17725564; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="hydroquinone-specific extradiol dioxygenase" /protein_id="NP_389170.1" /db_xref="EnsemblGenomes-Gn:BSU12870" /db_xref="EnsemblGenomes-Tr:CAB13144" /db_xref="GOA:O34689" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG13228" /db_xref="UniProtKB/Swiss-Prot:O34689" /translation="MKVNGIHHVSALTADAQKNLDFYKKVLGLKLVKKSVNQDEPTMY HLFYGDEVANPGTELTFFEIPRIAPFHAGTNSISSIGLRVPGTEALHYWKERFEEQQV THSGISKRAGRDILAFQDHEGQRLVLTADEEGKGYGLPVKQSGIPEEFSFRGLGPVEL TVPYAEPTLHVLTNILGFTEISREPVEGQGTAVILESGEGGAATEIHLIERNDLPRER QGKGSVHHVAFRVRDEEELAGWHRIISREGFSNSGIVERYYFKALYFREPNGILFELS TDGPGFMVDENLDELGQTIALPPYLEHRRAEIEAKLKPIQ*" /label="mhqA CDS" gene 1265408..1266358 /gene="mhqA" /locus_tag="BSU_12870" /old_locus_tag="BSU12870" /label="mhqA gene" downshifts 1266346 /Source="Nicolas_upshifts" /id="D701" /incds=0 /nref=95 /ntot=231 /MaxReadThrough="0.70251" /MaxDrop="5.11652" /score="51.2936135" /energy="-17.5" /TU="NA" /idTUdmin="U1040" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS 1266459..1266605 /locus_tag="BSU_12875" /old_locus_tag="BSU12875" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513953.1" /translation="MLIGRNGLKPFANMGDWYGMASAKILSLFINSLFIFACYTISKL DKKE*" /label="hypothetical protein CDS" gene 1266459..1266605 /locus_tag="BSU_12875" /old_locus_tag="BSU12875" /label="gene" CDS 1266613..1268763 /gene="ykcB" /locus_tag="BSU_12880" /old_locus_tag="BSU12880" /EC_number="2.4.1.-" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 18175906; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane glycosyl transferase" /protein_id="NP_389171.2" /db_xref="EnsemblGenomes-Gn:BSU12880" /db_xref="EnsemblGenomes-Tr:CAB13145" /db_xref="GOA:O34575" /db_xref="SubtiList:BG13229" /db_xref="UniProtKB/Swiss-Prot:O34575" /translation="MEKKKRELDIVLLLILLASAFLNIYNIWKDDTVNPYYTAAVTSM MQSFHNFFYASFDAAGFITVDKPPVTYQIQTISALIFGMHGWSVILPQALAGVGSVLL MYLLIKPTFGKTAARIASFVMACTPIAVAVARTNNVDALLVFFLLLATWLLFKAIRKG KLIWLLAAFFVVGVGFNTKMLQAYMILPAFLLFYLIAANATIKKKIVSLVSALAVLAA VSLSWPLIVDNIPASKRPYIGSSQTNSVLELAFGYNGIQRLTGQNSGGGQGAPNKDAS KEMSSSDNTQAPPNQSSSNSSSSDGKSSNGNMAAPPSNGQMPSGGQGGPPSGGDGGQG GPGGDGGKGGTGTGSKMQSGSGMFGTGTPGPLRLFQQELSDQISWLLPFAIFGIAGLL IAGARERRRLSVEQKETVFWVAWLVPIAGFFSVAEFFHHYYLIMLAPPIAALVGAGWV ALVHLYRNQTGWKAWLLPGAIIATTGFELFILRNYNDQIGVGWSIGVGVIGVLSAIAL LLFKQRQKPFSYYVSLAALLALLVMPMYWASTPLLYGGNSSLPETGPQLASMSGKGMG MSDATVNEKLIKYLEENNSGAEYLFATTDSNTAAPYIIKTKKAVMAIGGYSGSDPAIT LTQFKKLVKEGKVKYFLASGMGRGGNNDIVEWVEKNGKEVASEKWQSSSDQKTENTDS ADTSSSKASGENGKMGGPGGMNQSATLYELHADE*" /label="ykcB CDS" gene 1266613..1268763 /gene="ykcB" /locus_tag="BSU_12880" /old_locus_tag="BSU12880" /label="ykcB gene" promotor_no_box 1267502..1267602 /Source="Nicolas_upshift_promotors" /id="U1041" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.608391608391608" /psig="0.000999000999001" /xcortree=1488 /SigmaFactorBS="catcaagcgatggtaaatcctcaaatggcaatatggcggcgc ctccatccaatggccaaatgccaagcggcggtcaaggaggccctccaagcggcggaga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 1267562 /Source="Nicolas_upshifts" /id="U1041" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.608391608391608" /psig="0.000999000999001" /xcortree=1488 /SigmaFactorBS="catcaagcgatggtaaatcctcaaatggcaatatggcggcgc ctccatccaatggccaaatgccaagcggcggtcaaggaggccctccaagcggcggaga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1267650 /Source="Nicolas_upshifts" /id="D702" /incds=1 /nref=4 /ntot=10 /MaxReadThrough="0.56615" /MaxDrop="4.44711" /score="51.2936135" /energy="-17.5" /TU="NA" /idTUdmin="U1041" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 1268775..1269746 /gene="ykcC" /locus_tag="BSU_12890" /old_locus_tag="BSU12890" /EC_number="2.4.-.-" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_389172.2" /db_xref="EnsemblGenomes-Gn:BSU12890" /db_xref="EnsemblGenomes-Tr:CAB13146" /db_xref="GOA:O34319" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG13230" /db_xref="UniProtKB/Swiss-Prot:O34319" /translation="MSRHIQYSIVVPVYNEELVIHETYQRLKEVMDQTKENYELLFVN DGSKDRSIEILREHSLIDPRVKIIDFSRNFGHQIAITAGMDYAQGNAIVVIDADLQDP PELILEMIEKWKEGYEVVYAVRTKRKGETFFKKQTAAMFYRLLSGMTDIDIPIDTGDF RLMDRKVCDEMKRLKEKNPFVRGLVSWVGFKQTAVEYVRDERLAGETKYPLKKMLKLS MDGITTFSHKPLKLASYAGILMSGTGFLYMFIVLYLKLFTDSTITGWSSLIVIQLLFS GIVLLILGVIGEYIGRIYDEAKDRPLYIVQKSYGIENKRLYRDQHMS*" /label="ykcC CDS" gene 1268775..1269746 /gene="ykcC" /locus_tag="BSU_12890" /old_locus_tag="BSU12890" /label="ykcC gene" S_feature complement(1269103..1269744) /Source="Nicolas_S_feature" /locus_tag="new_1356775_1357416_c" /HighExp="T-0.40H, T0.0H, Salt, T0.30H, T-1.10H, C30, T-1.40H, S0, H2O2, T1.0H" /AntisenseName="ykcC" /AntisenseCor="9.6017422892053297E-4" /AntisenseRegPval=0 /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S461" downshifts complement(1269789) /Source="Nicolas_upshifts" /id="D703" /incds=0 /nref=9 /ntot=114 /MaxReadThrough="4.36795" /MaxDrop="4.15844" /score="4.98888048" /energy="-19.1" /TU="U1042" /idTUdmin="U1044" /TUdmin=489 /isTUend="FALSE" /label="downshifts" S_feature complement(1269814..1270180) /Source="Nicolas_S_feature" /locus_tag="new_1357486_1357852_c" /HighExp="T1.0H, T1.30H, T0.30H, T2.0H, T0.0H, T2.30H, T-0.40H, T3.0H, Salt, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99893799999999999" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S462" downshifts complement(1269857) /Source="Nicolas_upshifts" /id="D704" /incds=0 /nref=17 /ntot=157 /MaxReadThrough="6.61192" /MaxDrop="3.74411" /score="4.98888048" /energy="-19.1" /TU="U1042" /idTUdmin="U1044" /TUdmin=421 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1270160..1270175) /Source="Nicolas_upshift_promotors" /id="U1042" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1700 /SigmaFactorBS="agcggtctgaggctttttattagataaaagacctaattgttc taTGAAACTTTCtgacgagatatCCGTATATCATACAGAttgacatcattcacatcag a" /listShort="S462, S461" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1270180) /Source="Nicolas_upshifts" /id="U1042" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1700 /SigmaFactorBS="agcggtctgaggctttttattagataaaagacctaattgttc taTGAAACTTTCtgacgagatatCCGTATATCATACAGAttgacatcattcacatcag a" /listShort="S462, S461" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1270187..1270196) /Source="Nicolas_upshift_promotors" /id="U1042" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1700 /SigmaFactorBS="agcggtctgaggctttttattagataaaagacctaattgttc taTGAAACTTTCtgacgagatatCCGTATATCATACAGAttgacatcattcacatcag a" /listShort="S462, S461" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1270264..1271613) /gene="htrA" /locus_tag="BSU_12900" /old_locus_tag="BSU12900" /EC_number="3.4.21.107" /function="16.6: Maintain" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10692364, 11133960, 11555295, 12823817, 24362423" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10692364, 11133960, 11555295, 12823817, 24362423; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="membrane bound serine protease Do, quality control protease and chaperone (heat-shock protein)" /protein_id="NP_389173.2" /db_xref="EnsemblGenomes-Gn:BSU12900" /db_xref="EnsemblGenomes-Tr:CAB13147" /db_xref="GOA:O34358" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR001940" /db_xref="InterPro:IPR009003" /db_xref="InterPro:IPR036034" /db_xref="SubtiList:BG12608" /db_xref="UniProtKB/Swiss-Prot:O34358" /translation="MDNYRDENRTKGNENEVFLTKENDQSASYSARNVIHDQEKKKRG FGWFRPLLGGVIGGSLALGIYTFTPLGDHDSQDTAKQSSSQQQTQSVTATSTSSESKK SSSSSSAFKSEDSSKISDMVEDLSPAIVGITNLQAQSNSSLFGSSSSDSSEDTESGSG SGVIFKKENGKAYIITNNHVVEGASSLKVSLYDGTEVTAKLVGSDSLTDLAVLQISDD HVTKVANFGDSSDLRTGETVIAIGDPLGKDLSRTVTQGIVSGVDRTVSMSTSAGETSI NVIQTDAAINPGNSGGPLLNTDGKIVGINSMKISEDDVEGIGFAIPSNDVKPIAEELL SKGQIERPYIGVSMLDLEQVPQNYQEGTLGLFGSQLNKGVYIREVASGSPAEKAGLKA EDIIIGLKGKEIDTGSELRNILYKDAKIGDTVEVKILRNGKEMTKKIKLDQKEEKTS* " /label="htrA CDS" gene complement(1270264..1271613) /gene="htrA" /locus_tag="BSU_12900" /old_locus_tag="BSU12900" /label="htrA gene" downshifts complement(1270278) /Source="Nicolas_upshifts" /id="D705" /incds=0 /nref=198 /ntot=244 /MaxReadThrough="2.95586" /MaxDrop="5.35972" /score="30.7234179" /energy="-19.9" /TU="NA" /idTUdmin="U1044" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1271653..1271660 /Source="Nicolas_upshift_promotors" /id="U1043" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.948051948051948" /psig="0.999000999001" /xcortree=2991 /SigmaFactorBS="tcatgttcactccgtttctctattttcacatgtctatttaTA TTGATAggtttatgacttgaGTTTATCATAAACAAAAACTgtgggataaaaatgaaaa g" /GFF_Attribute="listShort" /listLong="proG" /label="promotor_-35" promotor_-10 complement(1271665..1271684) /Source="Nicolas_upshift_promotors" /id="U1044" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.865134865134865" /psig="0.998001998001998" /xcortree=1763 /SigmaFactorBS="tttccgcactttttcacaatttcccataatcttttcattttT ATCCCACagtttttgttTATGATAAACTCAAGTCATAaacctatcaatataaatagac a" /listShort="htrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1271673 /Source="Nicolas_upshifts" /id="U1043" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.948051948051948" /psig="0.999000999001" /xcortree=2991 /SigmaFactorBS="tcatgttcactccgtttctctattttcacatgtctatttaTA TTGATAggtttatgacttgaGTTTATCATAAACAAAAACTgtgggataaaaatgaaaa g" /GFF_Attribute="listShort" /listLong="proG" /label="upshifts" promotor_-10 1271675..1271694 /Source="Nicolas_upshift_promotors" /id="U1043" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.948051948051948" /psig="0.999000999001" /xcortree=2991 /SigmaFactorBS="tcatgttcactccgtttctctattttcacatgtctatttaTA TTGATAggtttatgacttgaGTTTATCATAAACAAAAACTgtgggataaaaatgaaaa g" /GFF_Attribute="listShort" /listLong="proG" /label="promotor_-10" upshifts complement(1271683) /Source="Nicolas_upshifts" /id="U1044" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.865134865134865" /psig="0.998001998001998" /xcortree=1763 /SigmaFactorBS="tttccgcactttttcacaatttcccataatcttttcattttT ATCCCACagtttttgttTATGATAAACTCAAGTCATAaacctatcaatataaatagac a" /listShort="htrA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1271685..1271767) /Source="Nicolas_S_feature" /locus_tag="new_1359357_1359439_c" /HighExp="Etha, dia5, S8, S6, T2.0H, T3.30H, dia15, T5.0H, BC, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.682" /TUlongSig="NA" /TUlongPSig="NA" /label="S463" promotor_-35 complement(1271695..1271702) /Source="Nicolas_upshift_promotors" /id="U1044" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.865134865134865" /psig="0.998001998001998" /xcortree=1763 /SigmaFactorBS="tttccgcactttttcacaatttcccataatcttttcattttT ATCCCACagtttttgttTATGATAAACTCAAGTCATAaacctatcaatataaatagac a" /listShort="htrA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1271724..1271730 /Source="Nicolas_upshift_promotors" /id="U1045" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.390609390609391" /psig="0.994005994005994" /xcortree=2259 /SigmaFactorBS="aaaaactgtgggataaaaatgaaaagattatgggaaATTGTG AaaaagtgcggaaaaCGGTACACTTCATATTGTATatgaaaggactgagtcgatggaa c" /listShort="proG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1271745..1271764 /Source="Nicolas_upshift_promotors" /id="U1045" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.390609390609391" /psig="0.994005994005994" /xcortree=2259 /SigmaFactorBS="aaaaactgtgggataaaaatgaaaagattatgggaaATTGTG AaaaagtgcggaaaaCGGTACACTTCATATTGTATatgaaaggactgagtcgatggaa c" /listShort="proG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1271748 /Source="Nicolas_upshifts" /id="U1045" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.390609390609391" /psig="0.994005994005994" /xcortree=2259 /SigmaFactorBS="aaaaactgtgggataaaaatgaaaagattatgggaaATTGTG AaaaagtgcggaaaaCGGTACACTTCATATTGTATatgaaaggactgagtcgatggaa c" /listShort="proG" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1271750..1271769) /Source="Nicolas_upshift_promotors" /id="U1046" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.416583416583417" /psig="0.682317682317682" /xcortree=624 /SigmaFactorBS="tcatatccgccatgctgccatatccaatcaatccaatctGTT CcatcgactcagtcctTTCATATACAATATGAAGTGtaccgttttccgcactttttca c" /listShort="S463, htrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1271767) /Source="Nicolas_upshifts" /id="U1046" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.416583416583417" /psig="0.682317682317682" /xcortree=624 /SigmaFactorBS="tcatatccgccatgctgccatatccaatcaatccaatctGTT CcatcgactcagtcctTTCATATACAATATGAAGTGtaccgttttccgcactttttca c" /listShort="S463, htrA" /GFF_Attribute="listLong" /label="upshifts" CDS 1271782..1272600 /gene="proCC" /locus_tag="BSU_12910" /old_locus_tag="BSU12910" /EC_number="1.5.1.2" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11418582" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11418582; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="redundant pyrroline-5-carboxylate reductase" /protein_id="NP_389174.1" /db_xref="EnsemblGenomes-Gn:BSU12910" /db_xref="EnsemblGenomes-Tr:CAB13148" /db_xref="GOA:Q00777" /db_xref="InterPro:IPR000304" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR028939" /db_xref="InterPro:IPR029036" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10841" /db_xref="UniProtKB/Swiss-Prot:Q00777" /translation="MEQIGLIGYGSMADMIARQLLKHEQIKENELFIETRTKGERLRA LMSDYPNVSADPLENWANTCQLILICVPPLHVIETMRRLYPYVNRNTHIVSIAAGVPL RLLEAETEAGISRVIPAITSEAEAGISLVVHSEALAAEKKERLNELLSVFSRVREIKE SNLDVASNLTSSAPGFIAAIFEELALSAVRNSSLSKEEAFDFLIHSLYGTGKMLIEKN MSFEETLERVATKGGITGEGAEVIHASVPDVFDEVFERTLRKYELLTEQVGKQT*" /label="proCC CDS" gene 1271782..1272600 /gene="proCC" /locus_tag="BSU_12910" /old_locus_tag="BSU12910" /label="proCC gene" promotor_-35 complement(1271785..1271788) /Source="Nicolas_upshift_promotors" /id="U1046" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.416583416583417" /psig="0.682317682317682" /xcortree=624 /SigmaFactorBS="tcatatccgccatgctgccatatccaatcaatccaatctGTT CcatcgactcagtcctTTCATATACAATATGAAGTGtaccgttttccgcactttttca c" /listShort="S463, htrA" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1272578 /Source="Nicolas_upshifts" /id="D706" /incds=0 /nref=90 /ntot=220 /MaxReadThrough="1.3818" /MaxDrop="4.43155" /score="-5.08770006" /energy="-5.3" /TU="NA" /idTUdmin="U1045" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1272657..1272664 /Source="Nicolas_upshift_promotors" /id="U1047" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2874 /SigmaFactorBS="tttatcactgaatgattgagatttttcccagttaTATTGCAT ttttcctcttttttTAATATAATTTGTTAGAATAttcataatttagtaaaaaaggagg a" /listShort="dppA, dppB, dppC, dppD, dppE, ykfA, ykfB, ykfC, ykfD, S465" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1272679..1272698 /Source="Nicolas_upshift_promotors" /id="U1047" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2874 /SigmaFactorBS="tttatcactgaatgattgagatttttcccagttaTATTGCAT ttttcctcttttttTAATATAATTTGTTAGAATAttcataatttagtaaaaaaggagg a" /listShort="dppA, dppB, dppC, dppD, dppE, ykfA, ykfB, ykfC, ykfD, S465" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1272683 /Source="Nicolas_upshifts" /id="U1047" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2874 /SigmaFactorBS="tttatcactgaatgattgagatttttcccagttaTATTGCAT ttttcctcttttttTAATATAATTTGTTAGAATAttcataatttagtaaaaaaggagg a" /listShort="dppA, dppB, dppC, dppD, dppE, ykfA, ykfB, ykfC, ykfD, S465" /GFF_Attribute="listLong" /label="upshifts" CDS 1272729..1273553 /gene="dppA" /locus_tag="BSU_12920" /old_locus_tag="BSU12920" /EC_number="3.4.11.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11069674, 11473256, 19340926" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11069674, 11473256, 19340926; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-alanyl-aminopeptidase" /protein_id="NP_389175.2" /db_xref="EnsemblGenomes-Gn:BSU12920" /db_xref="EnsemblGenomes-Tr:CAB13149" /db_xref="GOA:P26902" /db_xref="InterPro:IPR007035" /db_xref="InterPro:IPR027476" /db_xref="InterPro:IPR033824" /db_xref="InterPro:IPR036177" /db_xref="PDB:1HI9" /db_xref="SubtiList:BG10842" /db_xref="UniProtKB/Swiss-Prot:P26902" /translation="MKLYMSVDMEGISGLPDDTFVDSGKRNYERGRLIMTEEANYCIA EAFNSGCTEVLVNDSHSKMNNLMVEKLHPEADLISGDVKPFSMVEGLDDTFRGALFLG YHARASTPGVMSHSMIFGVRHFYINDRPVGELGLNAYVAGYYDVPVLMVAGDDRAAKE AEELIPNVTTAAVKQTISRSAVKCLSPAKAGRLLTEKTAFALQNKDKVKPLTPPDRPV LSIEFANYGQAEWANLMPGTEIKTGTTTVQFQAKDMLEAYQAMLVMTELAMRTSFC*" /label="dppA CDS" gene 1272729..1273553 /gene="dppA" /locus_tag="BSU_12920" /old_locus_tag="BSU12920" /label="dppA gene" CDS 1273570..1274496 /gene="dppB" /locus_tag="BSU_12930" /old_locus_tag="BSU12930" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:1766370, 7536291, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766370, 7536291, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="dipeptide ABC transporter (permease)" /protein_id="NP_389176.1" /db_xref="EnsemblGenomes-Gn:BSU12930" /db_xref="EnsemblGenomes-Tr:CAB13150" /db_xref="GOA:P26903" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG10843" /db_xref="UniProtKB/Swiss-Prot:P26903" /translation="MARYMIKRFWAMAATILVITTLTFVLMKVIPGSPFNEERGTNEA VQKNLEAYYHLDDPLIFQYIFYLKSIITFDFGPSIKKPSDSVNDMLERGFPVSFELGM TAIVIAVISGLVLGVIAALRRNGFLDYAAMSLAVLGISIPNFILATLLIQQFAVNLKL FPAATWTSPIHMVLPTAALAVGPMAIIARLTRSSMVEVLTQDYIRTAKAKGLSPFKII VKHALRNALMPVITVLGTLVASILTGSFVIEKIFAIPGMGKYFVESINQRDYPVIMGT TVFYSVILIIMLFLVDLAYGLLDPRIKLHKKG*" /label="dppB CDS" gene 1273570..1274496 /gene="dppB" /locus_tag="BSU_12930" /old_locus_tag="BSU12930" /label="dppB gene" CDS 1274502..1275464 /gene="dppC" /locus_tag="BSU_12940" /old_locus_tag="BSU12940" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:1766370, 7536291, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766370, 7536291, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="dipeptide ABC transporter (permease)" /protein_id="NP_389177.1" /db_xref="EnsemblGenomes-Gn:BSU12940" /db_xref="EnsemblGenomes-Tr:CAB13151" /db_xref="GOA:P26904" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR025966" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG10844" /db_xref="UniProtKB/Swiss-Prot:P26904" /translation="MNLPVQTDERQPEQHNQVPDEWFVLNQEKNREADSVKRPSLSYT QDAWRRLKKNKLAMAGLFILLFLFVMAVIGPFLSPHSVVRQSLTEQNLPPSADHWFGT DELGRDVFTRTWYGARISLFVGVMAALIDFLIGVIYGGVAGYKGGRIDSIMMRIIEVL YGLPYLLVVILLMVLMGPGLGTIIVALTVTGWVGMARIVRGQVLQIKNYEYVLASKTF GAKTFRIIRKNLLPNTMGAIIVQMTLTVPAAIFAESFLSFLGLGIQAPFASWGVMAND GLPTILSGHWWRLFFPAFFISLTMYAFNVLGDGLQDALDPKLRR*" /label="dppC CDS" gene 1274502..1275464 /gene="dppC" /locus_tag="BSU_12940" /old_locus_tag="BSU12940" /label="dppC gene" promotor_-35 1275196..1275201 /Source="Nicolas_upshift_promotors" /id="U1048" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=761 /SigmaFactorBS="cgcgaaaacctttcgcatcatccggaagaatttgctgcCGAA TActatgggagcgatcaTCGTACAAATGACATTAACcgtacctgccgccatattcgca g" /listShort="dppD, dppE, ykfA, ykfB, ykfC, ykfD, S465" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1275217..1275235 /Source="Nicolas_upshift_promotors" /id="U1048" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=761 /SigmaFactorBS="cgcgaaaacctttcgcatcatccggaagaatttgctgcCGAA TActatgggagcgatcaTCGTACAAATGACATTAACcgtacctgccgccatattcgca g" /listShort="dppD, dppE, ykfA, ykfB, ykfC, ykfD, S465" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1275218 /Source="Nicolas_upshifts" /id="U1048" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=761 /SigmaFactorBS="cgcgaaaacctttcgcatcatccggaagaatttgctgcCGAA TActatgggagcgatcaTCGTACAAATGACATTAACcgtacctgccgccatattcgca g" /listShort="dppD, dppE, ykfA, ykfB, ykfC, ykfD, S465" /GFF_Attribute="listLong" /label="upshifts" CDS 1275469..1276476 /gene="dppD" /locus_tag="BSU_12950" /old_locus_tag="BSU12950" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7536291" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7536291; Product type t : transporter" /codon_start=1 /transl_table=11 /product="dipeptide ABC transporter (ATP-binding subunit)" /protein_id="NP_389178.1" /db_xref="EnsemblGenomes-Gn:BSU12950" /db_xref="EnsemblGenomes-Tr:CAB13152" /db_xref="GOA:P26905" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR013563" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10845" /db_xref="UniProtKB/Swiss-Prot:P26905" /translation="MEKVLSVQNLHVSFTTYGGTVQAVRGVSFDLYKGETFAIVGESG CGKSVTSQSIMGLLPPYSAKVTDGRILFKNKDLCRLSDKEMRGIRGADISMIFQDPMT ALNPTLTVGDQLGEALLRHKKMSKKAARKEVLSMLSLVGIPDPGERLKQYPHQFSGGM RQRIVIAMALICEPDILIADEPTTALDVTIQAQILELFKEIQRKTDVSVILITHDLGV VAQVADRVAVMYAGKMAEIGTRKDIFYQPQHPYTKGLLGSVPRLDLNGAELTPIDGTP PDLFSPPPGCPFAARCPNRMVVCDRVYPGQTIRSDSHTVNCWLQDQRAEHAVLSGDAK D*" /label="dppD CDS" gene 1275469..1276476 /gene="dppD" /locus_tag="BSU_12950" /old_locus_tag="BSU12950" /label="dppD gene" CDS 1276479..1278128 /gene="dppE" /locus_tag="BSU_12960" /old_locus_tag="BSU12960" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7783641, 8793880, 11390694" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7783641, 8793880, 11390694; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="dipeptide ABC transporter (dipeptide-binding lipoprotein)" /protein_id="NP_389179.2" /db_xref="EnsemblGenomes-Gn:BSU12960" /db_xref="EnsemblGenomes-Tr:CAB13153" /db_xref="GOA:P26906" /db_xref="InterPro:IPR000914" /db_xref="InterPro:IPR023765" /db_xref="InterPro:IPR030678" /db_xref="SubtiList:BG10846" /db_xref="UniProtKB/Swiss-Prot:P26906" /translation="MKRGKRMKRVKKLWGMGLALGLSFALMGCTANEQAGKEGSHDKA KTSGEKVLYVNNENEPTSFDPPIGFNNVSWQPLNNIMEGLTRLGKDHEPEPAMAEKWS VSKDNKTYTFTIRENAKWTNGDPVTAGDFEYAWKRMLDPKKGASSAFLGYFIEGGEAY NSGKGKKDDVKVTAKDDRTLEVTLEAPQKYFLSVVSNPAYFPVNEKVDKDNPKWFAES DTFVGNGPFKLTEWKHDDSITMEKSDTYWDKDTVKLDKVKWAMVSDRNTDYQMFQSGE LDTAYVPAELSDQLLDQDNVNIVDQAGLYFYRFNVNMEPFQNENIRKAFAMAVDQEEI VKYVTKNNEKPAHAFVSPGFTQPDGKDFREAGGDLIKPNESKAKQLLEKGMKEENYNK LPAITLTYSTKPEHKKIAEAIQQKLKNSLGVDVKLANMEWNVFLEDQKALKFQFSQSS FLPDYADPISFLEAFQTGNSMNRTGWANKEYDQLIKQAKNEADEKTRFSLMHQAEELL INEAPIIPVYFYNQVHLQNEQVKGIVRHPVGYIDLKWADKN*" /label="dppE CDS" gene 1276479..1278128 /gene="dppE" /locus_tag="BSU_12960" /old_locus_tag="BSU12960" /label="dppE gene" downshifts 1278122 /Source="Nicolas_upshifts" /id="D707" /incds=0 /nref=2 /ntot=25 /MaxReadThrough="6.73127" /MaxDrop="3.5888" /score="22.838155" /energy="-13.9" /TU="U1047,U1048" /idTUdmin="U1048" /TUdmin="-4469" /isTUend="FALSE" /label="downshifts" CDS 1278216..1279175 /gene="ldcA" /locus_tag="BSU_12970" /old_locus_tag="BSU12970" /EC_number="3.4.17.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10428950, 15101989, 18535144, 20944232, 24123814; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="muropeptide L,D-carboxypeptidase" /protein_id="NP_389180.2" /db_xref="EnsemblGenomes-Gn:BSU12970" /db_xref="EnsemblGenomes-Tr:CAB13154" /db_xref="GOA:O34851" /db_xref="InterPro:IPR003507" /db_xref="InterPro:IPR027461" /db_xref="InterPro:IPR027478" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG13231" /db_xref="UniProtKB/Swiss-Prot:O34851" /translation="MKGVFSLNYKPKALNKGDTVGVIAPASPPDPKKLDTALLFLEEL GLQVKLGKALKNQHGYLAGQDDERLADLHEMFRDDEVKAVLCACGGFGTGRIAAGIDF SLIRKHPKIFWGYSDITFLHTAIHQNTGLVTFHGPMLSTDIGLDDVHPLTKASYKQLF QETEFTYTEELSPLTELVPGKAEGELVGGNLSLLTSTLGTPFEIDTRGKLLFIEDIDE EPYQIDRMLNQLKMGGKLTDAAGILVCDFHNCVPVKREKSLSLEQVLEDYIISAGRPA LRGFKIGHCSPSIAVPIGAKAAMNTAEKTAVIEAGVSEGALKT*" /label="ldcA CDS" gene 1278216..1279175 /gene="ldcA" /locus_tag="BSU_12970" /old_locus_tag="BSU12970" /label="ldcA gene" CDS 1279172..1280272 /gene="aeeB" /locus_tag="BSU_12980" /old_locus_tag="BSU12980" /EC_number="5.1.1.20" /function="16.11: Scavenge (Catabolism)" /function="16.5: Explore" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11747447, 11747448, 15101989" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11747447, 11747448, 15101989; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-Ala-D/L-Glu epimerase" /protein_id="NP_389181.1" /db_xref="EnsemblGenomes-Gn:BSU12980" /db_xref="EnsemblGenomes-Tr:CAB13155" /db_xref="GOA:O34508" /db_xref="InterPro:IPR013341" /db_xref="InterPro:IPR013342" /db_xref="InterPro:IPR029017" /db_xref="InterPro:IPR029065" /db_xref="InterPro:IPR034390" /db_xref="InterPro:IPR036849" /db_xref="PDB:1JPM" /db_xref="PDB:1TKK" /db_xref="SubtiList:BG13232" /db_xref="UniProtKB/Swiss-Prot:O34508" /translation="MKIIRIETSRIAVPLTKPFKTALRTVYTAESVIVRITYDSGAVG WGEAPPTLVITGDSMDSIESAIHHVLKPALLGKSLAGYEAILHDIQHLLTGNMSAKAA VEMALYDGWAQMCGLPLYQMLGGYRDTLETDYTVSVNSPEEMAADAENYLKQGFQTLK IKVGKDDIATDIARIQEIRKRVGSAVKLRLDANQGWRPKEAVTAIRKMEDAGLGIELV EQPVHKDDLAGLKKVTDATDTPIMADESVFTPRQAFEVLQTRSADLINIKLMKAGGIS GAEKINAMAEACGVECMVGSMIETKLGITAAAHFAASKRNITRFDFDAPLMLKTDVFN GGITYSGSTISMPGKPGLGIIGAALLKGEKEQ*" /label="aeeB CDS" gene 1279172..1280272 /gene="aeeB" /locus_tag="BSU_12980" /old_locus_tag="BSU12980" /label="aeeB gene" CDS 1280269..1281159 /gene="eepC" /locus_tag="BSU_12990" /old_locus_tag="BSU12990" /EC_number="3.4.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15101989, 20944232" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15101989, 20944232; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="gamma-D-glutamyl-L-diaminoacid endopeptidase" /protein_id="NP_389182.2" /db_xref="EnsemblGenomes-Gn:BSU12990" /db_xref="EnsemblGenomes-Tr:CAB13156" /db_xref="GOA:O35010" /db_xref="InterPro:IPR000064" /db_xref="SubtiList:BG13233" /db_xref="UniProtKB/Swiss-Prot:O35010" /translation="MMHTVISAVANIWTAPDSPRPSDQFMLQPTVMIRDWLERMTYDE RLGLCTDNVIQTQVLFGEKVLVTAEQGEWVSVIVPSQPSRKDPRGYPGWMKKYQLEKT KPIHTQHDVMISKPAAFLYRSNGEKEIELSFLTVLPLIAKENGYFKVSTVFGERFVRQ SDAVPVSQQKGTAEDIIQTGAFFLGLPYLWGGISGFGFDCSGFMYSIFKANGYSIPRD AGDQAKAGKGVPLDDMKAGDLLFFAYEEGKGAIHHVGLYVGGGKMLHSPKTGKSIEIL TLTETIYEKELCAVRRCFSE*" /label="eepC CDS" gene 1280269..1281159 /gene="eepC" /locus_tag="BSU_12990" /old_locus_tag="BSU12990" /label="eepC gene" CDS 1281172..1282161 /gene="ykfD" /locus_tag="BSU_13000" /old_locus_tag="BSU13000" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15101989; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative cell wall oligopeptide ABC transporter (ATP binding protein)" /protein_id="NP_389183.2" /db_xref="EnsemblGenomes-Gn:BSU13000" /db_xref="EnsemblGenomes-Tr:CAB13157" /db_xref="GOA:C0SP98" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR013563" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13234" /db_xref="UniProtKB/Swiss-Prot:C0SP98" /translation="MRRLPLLEVSQLKMHFDAGKKRTVKAVDGVTFQIREGETFGLVG ESGCGKSTLGRVLMRLYQPTEGSVTYRGTNLHALSEKEQFAFNRKLQMIFQDPYASLN PRMTVREIILEPMEIHNLYNTHKARLLVVDELLEAVGLHPDFGSRYPHEFSGGQRQRI GIARALSLNPEFIVADEPISALDVSVQAQVVNLLKRLQKEKGLTFLFIAHDLSMVKHI SDRIGVMYLGHMMEITESGTLYREPLHPYTKALLSSIPIPDPELEDKRERILLKGELP SPVNPPSGCVFRTRCPEAMPECGESRPQLQEIEPGRFVACHLYRNAETKEKVR*" /label="ykfD CDS" gene 1281172..1282161 /gene="ykfD" /locus_tag="BSU_13000" /old_locus_tag="BSU13000" /label="ykfD gene" S_feature complement(1281455..1282182) /Source="Nicolas_S_feature" /locus_tag="new_1369127_1369854_c" /HighExp="Etha, S7, Gly, M40t90, C30, H2O2, M0t90, dia15, T1.0H, S8" /AntisenseName="ykfD" /AntisenseCor="-6.3474114158352593E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S464" downshifts 1282151 /Source="Nicolas_upshifts" /id="D708" /incds=0 /nref=1 /ntot=91 /MaxReadThrough="5.08319" /MaxDrop="3.1399" /score="-3.10371155" /energy="-13.9" /TU="U1047,U1048" /idTUdmin="U1048" /TUdmin="-440" /isTUend="FALSE" /label="downshifts" S_feature 1282196..1283364 /Source="Nicolas_S_feature" /locus_tag="new_1369868_1371036" /HighExp="T3.30H, T4.0H, T3.0H, T5.0H, T2.30H, T2.0H, S1, M9-stat, T1.30H, HiOs" /AntisenseName="ykgB" /AntisenseCor="-0.33524952291190102" /AntisenseRegPval="-7.8" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="0.997, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S465" CDS complement(1282204..1283253) /gene="pgl" /locus_tag="BSU_13010" /old_locus_tag="BSU13010" /EC_number="3.1.1.31" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:22960854, 28032445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22960854, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="6-phosphogluconolactonase" /protein_id="NP_389184.1" /db_xref="EnsemblGenomes-Gn:BSU13010" /db_xref="EnsemblGenomes-Tr:CAB13158" /db_xref="GOA:O34499" /db_xref="InterPro:IPR011048" /db_xref="InterPro:IPR015943" /db_xref="InterPro:IPR019405" /db_xref="SubtiList:BG13236" /db_xref="UniProtKB/Swiss-Prot:O34499" /translation="MTKYIGYVGTYTKGGSEGIYSFELDTEKKALSEPKLAAKLGNPT YVATNKNNTILYSIEKADGQGGVAAYQIDKNSGELTFLNHQLIDGPSPCHVSVDDQNQ FVLTANYHSGKVHVFPVQEDGSLQSPVSEAAHTGKGPHERQEKPHTHYAGFTPEHNYV VAVDLGIDKLYTYKLKDGVLTESGSHSFAPGAGPRHIAFHPKEKYAYVMTELSNEVIA LEYNPTAGEFREIQVVSAIPDDFTDNSQGSAIHVTQDGRFVYVANRGHDSIAVFEVNQ YSGELAFVERVSTEGNWPRDFVFDPTEGFLVASNEETGNLVLFERDKETGRLTLLPST VSVPYPVCVKFLHQV*" /label="pgl CDS" gene complement(1282204..1283253) /gene="pgl" /locus_tag="BSU_13010" /old_locus_tag="BSU13010" /label="pgl gene" downshifts complement(1282227) /Source="Nicolas_upshifts" /id="D709" /incds=0 /nref=208 /ntot=262 /MaxReadThrough="5.12776" /MaxDrop="6.0668" /score="24.6986564" /energy="-15.6" /TU="U1050" /idTUdmin="U1049" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1283280..1283299) /Source="Nicolas_upshift_promotors" /id="U1049" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=2235 /SigmaFactorBS="ggcgaatgaagaatcttcccctttttcatgTTTTGAACagct tattttatcaAGATACGTTAATATAGAGGTgacatcatttttaagggggaaatcgcat g" /listShort="ykgB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1283291) /Source="Nicolas_upshifts" /id="U1049" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=2235 /SigmaFactorBS="ggcgaatgaagaatcttcccctttttcatgTTTTGAACagct tattttatcaAGATACGTTAATATAGAGGTgacatcatttttaagggggaaatcgcat g" /listShort="ykgB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1283314..1283321) /Source="Nicolas_upshift_promotors" /id="U1049" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=2235 /SigmaFactorBS="ggcgaatgaagaatcttcccctttttcatgTTTTGAACagct tattttatcaAGATACGTTAATATAGAGGTgacatcatttttaagggggaaatcgcat g" /listShort="ykgB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1283343..1284203) /gene="ddaH" /locus_tag="BSU_13020" /old_locus_tag="BSU13020" /EC_number="3.5.3.18" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 27258038; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="N(G),N(G)-dimethylarginine dimethylaminohydrolase" /protein_id="NP_389185.2" /db_xref="EnsemblGenomes-Gn:BSU13020" /db_xref="EnsemblGenomes-Tr:CAB13159" /db_xref="GOA:O34497" /db_xref="InterPro:IPR033199" /db_xref="SubtiList:BG13235" /db_xref="UniProtKB/Swiss-Prot:O34497" /translation="MDVSIPKSQHKTVCRTEYGTLQKVILCKPEHMTIKDVINETQKH FEDDNIHVKTANDQHSRLVEALRSHNVEVVLLPVRDGLPEQVFTRDIGFVIGEKAFLS SMTEPIRQGEEAVIKDFFHSQGISYTRMLDTSIEGGDVIIDDDIVYVGISQRTDISAI GQLEEALPEYTIVPVKLHEKFLHLDCVFNIISESEALIYSQAIEPDAADMLAKRYDLI EVPEDEQFTLGTNVLSIGKKTIISLPGNRHVNQQLSKRGYHIIEIDLSEIIKSGGSFR CCTMPLIRGE*" /label="ddaH CDS" gene complement(1283343..1284203) /gene="ddaH" /locus_tag="BSU_13020" /old_locus_tag="BSU13020" /label="ddaH gene" promotor_-10 complement(1284228..1284246) /Source="Nicolas_upshift_promotors" /id="U1050" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=242 /SigmaFactorBS="aaacaatattctcttccatttgtctaaaatttaaaatGGTTT AAtgattttcatgatgaGGGAATAATAAATGTATTCttcacactttaggaggaaaaac a" /listShort="ykgA, ykgB, S464" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1284245) /Source="Nicolas_upshifts" /id="U1050" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=242 /SigmaFactorBS="aaacaatattctcttccatttgtctaaaatttaaaatGGTTT AAtgattttcatgatgaGGGAATAATAAATGTATTCttcacactttaggaggaaaaac a" /listShort="ykgA, ykgB, S464" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1284262..1284268) /Source="Nicolas_upshift_promotors" /id="U1050" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=242 /SigmaFactorBS="aaacaatattctcttccatttgtctaaaatttaaaatGGTTT AAtgattttcatgatgaGGGAATAATAAATGTATTCttcacactttaggaggaaaaac a" /listShort="ykgA, ykgB, S464" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1284277..1284284 /Source="Nicolas_upshift_promotors" /id="U1051" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.933066933066933" /psig=1 /xcortree=2004 /SigmaFactorBS="cctcatcatgaaaatcattaaaccattttaaaTTTTAGACaa atggaagagaaTATTGTTTAATAGGAGAATAtaagtgcatttagctaaaagatcagac a" /listShort="ykhA, S466, hmp" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1284298..1284317 /Source="Nicolas_upshift_promotors" /id="U1051" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.933066933066933" /psig=1 /xcortree=2004 /SigmaFactorBS="cctcatcatgaaaatcattaaaccattttaaaTTTTAGACaa atggaagagaaTATTGTTTAATAGGAGAATAtaagtgcatttagctaaaagatcagac a" /listShort="ykhA, S466, hmp" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1284305 /Source="Nicolas_upshifts" /id="U1051" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.933066933066933" /psig=1 /xcortree=2004 /SigmaFactorBS="cctcatcatgaaaatcattaaaccattttaaaTTTTAGACaa atggaagagaaTATTGTTTAATAGGAGAATAtaagtgcatttagctaaaagatcagac a" /listShort="ykhA, S466, hmp" /GFF_Attribute="listLong" /label="upshifts" CDS 1284363..1284881 /gene="ykhA" /locus_tag="BSU_13030" /old_locus_tag="BSU13030" /EC_number="3.1.2.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12426338, 18247525, 24623648, 24722906; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous acyl-CoA thioesterase" /protein_id="NP_389186.2" /db_xref="EnsemblGenomes-Gn:BSU13030" /db_xref="EnsemblGenomes-Tr:CAB13160" /db_xref="GOA:P49851" /db_xref="InterPro:IPR006683" /db_xref="InterPro:IPR029069" /db_xref="InterPro:IPR033120" /db_xref="SubtiList:BG11417" /db_xref="UniProtKB/Swiss-Prot:P49851" /translation="METPETRFCKESKVVKTSRVFPLDTNNHNTLFGGKLMSYIDDIA SISAARHCRRETVTASMDSVDFLKPIGQKDSVCLESYVTWVGTSSMEVFVKVIKEHLM TGERELAATSFLTFVALDSNGKPVPVPRVVPETEEEIMLHNTAVQRANERKNRKRHSQ ALANALGTDKPW*" /label="ykhA CDS" gene 1284363..1284881 /gene="ykhA" /locus_tag="BSU_13030" /old_locus_tag="BSU13030" /label="ykhA gene" downshifts 1284872 /Source="Nicolas_upshifts" /id="D710" /incds=0 /nref=34 /ntot=265 /MaxReadThrough="4.66856" /MaxDrop="4.77681" /score="24.0889455" /energy="-10.9" /TU="U1051" /idTUdmin="U1051" /TUdmin="-1436" /isTUend="FALSE" /label="downshifts" promotor_-35 1284946..1284952 /Source="Nicolas_upshift_promotors" /id="U1052" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=854 /SigmaFactorBS="tgttttgggtttttttgtacttttcaatggtgattattacaa TGGTTAGtccgtttttgctaGGGGATTCTATAaaaaagcaacaaatgtcatgttaaat t" /listShort="S466, hmp" /listLong="S467, ykjA, ykkA" /label="promotor_-35" S_feature 1284964..1285070 /Source="Nicolas_S_feature" /locus_tag="new_1372636_1372742" /HighExp="Etha, S5, S6, S8, nit, S7, ferm, S4, dia15, dia5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigA" /TUshortPSig="0.998, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S466" upshifts 1284964 /Source="Nicolas_upshifts" /id="U1052" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=854 /SigmaFactorBS="tgttttgggtttttttgtacttttcaatggtgattattacaa TGGTTAGtccgtttttgctaGGGGATTCTATAaaaaagcaacaaatgtcatgttaaat t" /listShort="S466, hmp" /listLong="S467, ykjA, ykkA" /label="upshifts" promotor_-10 1284966..1284977 /Source="Nicolas_upshift_promotors" /id="U1052" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=854 /SigmaFactorBS="tgttttgggtttttttgtacttttcaatggtgattattacaa TGGTTAGtccgtttttgctaGGGGATTCTATAaaaaagcaacaaatgtcatgttaaat t" /listShort="S466, hmp" /listLong="S467, ykjA, ykkA" /label="promotor_-10" promotor_-35 1285045..1285048 /Source="Nicolas_upshift_promotors" /id="U1053" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.452547452547453" /psig="0.99000999000999" /xcortree=1618 /SigmaFactorBS="ttgtgacaactttattaaagattcattttagatATATctttt attcgtaagaTCATGTATTTTAAAGATATAttttaaatacatcttttcgaaaggattg t" /listShort="hmp, S467, ykjA, ykkA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1285064..1285083 /Source="Nicolas_upshift_promotors" /id="U1053" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.452547452547453" /psig="0.99000999000999" /xcortree=1618 /SigmaFactorBS="ttgtgacaactttattaaagattcattttagatATATctttt attcgtaagaTCATGTATTTTAAAGATATAttttaaatacatcttttcgaaaggattg t" /listShort="hmp, S467, ykjA, ykkA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1285072 /Source="Nicolas_upshifts" /id="U1053" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.452547452547453" /psig="0.99000999000999" /xcortree=1618 /SigmaFactorBS="ttgtgacaactttattaaagattcattttagatATATctttt attcgtaagaTCATGTATTTTAAAGATATAttttaaatacatcttttcgaaaggattg t" /listShort="hmp, S467, ykjA, ykkA" /GFF_Attribute="listLong" /label="upshifts" CDS 1285120..1286319 /gene="hmpA" /locus_tag="BSU_13040" /old_locus_tag="BSU13040" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10658656, 10972836, 12469342, 15231799, 15751990, 16261196, 16517672, 17293416, 24214949, 26786044" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10658656, 10972836, 12469342, 15231799, 15751990, 16261196, 16517672, 17293416, 24214949, 26786044; Product type c: carrier" /codon_start=1 /transl_table=11 /product="flavohemoglobin" /protein_id="NP_389187.1" /db_xref="EnsemblGenomes-Gn:BSU13040" /db_xref="EnsemblGenomes-Tr:CAB13161" /db_xref="GOA:P49852" /db_xref="InterPro:IPR000971" /db_xref="InterPro:IPR001221" /db_xref="InterPro:IPR001433" /db_xref="InterPro:IPR008333" /db_xref="InterPro:IPR009050" /db_xref="InterPro:IPR017927" /db_xref="InterPro:IPR017938" /db_xref="InterPro:IPR023950" /db_xref="SubtiList:BG11418" /db_xref="UniProtKB/Swiss-Prot:P49852" /translation="MLDNKTIEIIKSTVPVLQQHGETITGRFYDRMFQDHPELLNIFN QTNQKKKTQRTALANAVIAAAANIDQLGNIIPVVKQIGHKHRSIGIKPEHYPIVGKYL LIAIKDVLGDAATPDIMQAWEKAYGVIADAFIGIEKDMYEQAEEQAGGWKEYKPFVIA KKERESKEITSFYLKPEDSKPLPEFQAGQYISIKVRIPDSEYTHIRQYSLSDMPGKDY YRISVKKDGVVSSYLHDGLQEGDSIEISAPAGDFVLDHASQKDLVLISAGVGITPMIS MLKTSVSKQPERQILFIHAAKNSEYHALRHEVEEAAKHSAVKTAFVYREPTEEDRAGD LHFHEGQIDQQFLKELIANTDADYYICGSPSFITAMHKLVSELGSAPESIHYELFGPQ LSLAQSV*" /label="hmpA CDS" gene 1285120..1286319 /gene="hmpA" /locus_tag="BSU_13040" /old_locus_tag="BSU13040" /label="hmpA gene" downshifts 1286308 /Source="Nicolas_upshifts" /id="D711" /incds=0 /nref=10 /ntot=59 /MaxReadThrough="6.06442" /MaxDrop="4.19301" /score="11.2868967" /energy="-9.3" /TU="U1053" /idTUdmin="U1051" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 1286353..1286724 /Source="Nicolas_S_feature" /locus_tag="new_1374025_1374396" /HighExp="nit, B36, B60, Etha, BI, M40t90, LBGtran, M0t90, BT, S6" /AntisenseName="ykzH" /AntisenseCor="7.6554747052539299E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.99" /TUlongSig="SigGF" /TUlongPSig="0.998" /label="S467" CDS complement(1286396..1286620) /gene="ykzH" /locus_tag="BSU_13050" /old_locus_tag="BSU13050" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389188.1" /db_xref="EnsemblGenomes-Gn:BSU13050" /db_xref="EnsemblGenomes-Tr:CAB13162" /db_xref="SubtiList:BG13336" /db_xref="UniProtKB/Swiss-Prot:O31653" /translation="MKNQKSNTLWPFDLPLAPQPEGYQQQTIDRLAGLELRMKQLIRA IEVNNELLRTMQEQQNRVCTNGSGSVIVRM*" /label="ykzH CDS" gene complement(1286396..1286620) /gene="ykzH" /locus_tag="BSU_13050" /old_locus_tag="BSU13050" /label="ykzH gene" promotor_-35 1286700..1286706 /Source="Nicolas_upshift_promotors" /id="U1054" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=927 /SigmaFactorBS="gttcaggcgatatgcacgttcgcctagacactgaTGCATAGa gggcctgccacgGGGCACAATAGGctcaatatgaccagcggatggaggtaaagatcgg t" /listShort="ykjA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1286720..1286731 /Source="Nicolas_upshift_promotors" /id="U1054" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=927 /SigmaFactorBS="gttcaggcgatatgcacgttcgcctagacactgaTGCATAGa gggcctgccacgGGGCACAATAGGctcaatatgaccagcggatggaggtaaagatcgg t" /listShort="ykjA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1286726 /Source="Nicolas_upshifts" /id="U1054" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=927 /SigmaFactorBS="gttcaggcgatatgcacgttcgcctagacactgaTGCATAGa gggcctgccacgGGGCACAATAGGctcaatatgaccagcggatggaggtaaagatcgg t" /listShort="ykjA" /GFF_Attribute="listLong" /label="upshifts" CDS 1286765..1287496 /gene="ykjA" /locus_tag="BSU_13060" /old_locus_tag="BSU13060" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="NP_389189.1" /db_xref="EnsemblGenomes-Gn:BSU13060" /db_xref="EnsemblGenomes-Tr:CAB13163" /db_xref="GOA:P49853" /db_xref="InterPro:IPR007353" /db_xref="InterPro:IPR023090" /db_xref="SubtiList:BG11419" /db_xref="UniProtKB/Swiss-Prot:P49853" /translation="MLWMVWVFLLKPVIVFSIAYILFRLAGKKAVSQMNNFDLLLTFA IGTIISEPILTSKLPMSIYYAGAFLVLYLIMSKLSLSNKWRWLLVVSPTVLIRNGDID ERGLRKERLTVNELLGKLREKGYADPADIDLAIIEETGEVSVIPKEEARAVQVRDLNM EAERNFIPIPLILDGEILDHNLKYLQKNRSWLFEKLEEKGYSPKLLSSIILGTMNARG DISLDLNTANEPQHDPYLYKPGNNN*" /label="ykjA CDS" gene 1286765..1287496 /gene="ykjA" /locus_tag="BSU_13060" /old_locus_tag="BSU13060" /label="ykjA gene" downshifts 1287474 /Source="Nicolas_upshifts" /id="D712" /incds=0 /nref=14 /ntot=29 /MaxReadThrough="2.84532" /MaxDrop="4.44655" /score="17.2468985" /energy="-7.2" /TU="U1053" /idTUdmin="U1054" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1287535..1287543 /Source="Nicolas_upshift_promotors" /id="U1055" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=551 /SigmaFactorBS="ctctctcttgtaatgagagcttttttcttttttAAAGGGAAT ttttgtttggTGTCAAATGTACCTAGTTAggaggggaactgaacatgaaggacttatc c" /listShort="ykkA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1287554..1287572 /Source="Nicolas_upshift_promotors" /id="U1055" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=551 /SigmaFactorBS="ctctctcttgtaatgagagcttttttcttttttAAAGGGAAT ttttgtttggTGTCAAATGTACCTAGTTAggaggggaactgaacatgaaggacttatc c" /listShort="ykkA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1287562 /Source="Nicolas_upshifts" /id="U1055" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=551 /SigmaFactorBS="ctctctcttgtaatgagagcttttttcttttttAAAGGGAAT ttttgtttggTGTCAAATGTACCTAGTTAggaggggaactgaacatgaaggacttatc c" /listShort="ykkA" /GFF_Attribute="listLong" /label="upshifts" CDS 1287588..1288115 /gene="ykkA" /locus_tag="BSU_13070" /old_locus_tag="BSU13070" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389190.1" /db_xref="EnsemblGenomes-Gn:BSU13070" /db_xref="EnsemblGenomes-Tr:CAB13164" /db_xref="InterPro:IPR024775" /db_xref="InterPro:IPR034660" /db_xref="SubtiList:BG11420" /db_xref="UniProtKB/Swiss-Prot:P49854" /translation="MKDLSIRNDMAPTVSLLYSAVEENSLRLASIVSHMTHSELYYKG RCQTKNSTAQLLHHITNVDIRWVWRIKENRIPDHIEQAYGPMTDESGRLPEPVNQPDL DELLKRHQHVVEKLKSVCFTLTENALNQPLSFEGDTATIRWGIWHMADHNRYHQAHIE ALKKEWKQDVAKYER*" /label="ykkA CDS" gene 1287588..1288115 /gene="ykkA" /locus_tag="BSU_13070" /old_locus_tag="BSU13070" /label="ykkA gene" CDS 1288105..1288623 /gene="ykkB" /locus_tag="BSU_13080" /old_locus_tag="BSU13080" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12793527; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_389191.1" /db_xref="EnsemblGenomes-Gn:BSU13080" /db_xref="EnsemblGenomes-Tr:CAB13165" /db_xref="GOA:P49855" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG11421" /db_xref="UniProtKB/Swiss-Prot:P49855" /translation="MNAKTKLVTDRIRLRCMEDRDQATLFGLLFNDPDVMTYYSGLKD KRQTREWVNWNQRNEKGYGVSLWIAEDKRTGEFLGQCGIVPQQIENQTVMEIGYMFAR RHWGNGYAQEAARACLDYGFNERQFGKMAALIDPGNKASIRVAEKIGMHYSKTIRKWN KPIAVYERKSYN*" /label="ykkB CDS" gene 1288105..1288623 /gene="ykkB" /locus_tag="BSU_13080" /old_locus_tag="BSU13080" /label="ykkB gene" promotor_-35 1288617..1288624 /Source="Nicolas_upshift_promotors" /id="U1056" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.838161838161838" /psig=1 /xcortree=3144 /SigmaFactorBS="gaataaaccgatcgcggtatatgaaagaaaatcttaCAATTG AAagatagagctgagTTTAGTATCATGATATCATGtaaagttttctagggttccgcat g" /listShort="NA, ykkC, ykkD" /listLong="purU" /label="promotor_-35" promotor_-10 1288638..1288657 /Source="Nicolas_upshift_promotors" /id="U1056" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.838161838161838" /psig=1 /xcortree=3144 /SigmaFactorBS="gaataaaccgatcgcggtatatgaaagaaaatcttaCAATTG AAagatagagctgagTTTAGTATCATGATATCATGtaaagttttctagggttccgcat g" /listShort="NA, ykkC, ykkD" /listLong="purU" /label="promotor_-10" upshifts 1288641 /Source="Nicolas_upshifts" /id="U1056" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.838161838161838" /psig=1 /xcortree=3144 /SigmaFactorBS="gaataaaccgatcgcggtatatgaaagaaaatcttaCAATTG AAagatagagctgagTTTAGTATCATGATATCATGtaaagttttctagggttccgcat g" /listShort="NA, ykkC, ykkD" /listLong="purU" /label="upshifts" misc_RNA 1288656..1288767 /gene="gdwA" /locus_tag="BSU_misc_RNA_16" /product="guanidine-sensing riboswitch (binds free guanidinium)" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17908319, 21317561, 27989440, 28001368, 28017522, 28107646, 28212758; Product type n: RNA" /label="gdwA RNA" gene 1288656..1288767 /gene="gdwA" /locus_tag="BSU_misc_RNA_16" /label="gdwA gene" downshifts 1288730 /Source="Nicolas_upshifts" /id="D713" /incds=0 /nref=205 /ntot=246 /MaxReadThrough="3.70824" /MaxDrop="6.58389" /score="30.3456563" /energy="-18.5" /TU="U1056" /idTUdmin="U1056" /TUdmin="-789" /isTUend="FALSE" /label="downshifts" CDS 1288845..1289183 /gene="gdnC" /locus_tag="BSU_13090" /old_locus_tag="BSU13090" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10735877, 10931887, 15096624, 28001372" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10735877, 10931887, 15096624, 28001372; Product type t: transporter" /codon_start=1 /transl_table=11 /product="guanidinium efflux transporter subunit" /protein_id="NP_389192.1" /db_xref="EnsemblGenomes-Gn:BSU13090" /db_xref="EnsemblGenomes-Tr:CAB13166" /db_xref="GOA:P49856" /db_xref="InterPro:IPR000390" /db_xref="SubtiList:BG11422" /db_xref="UniProtKB/Swiss-Prot:P49856" /translation="MKWGLVVLAAVFEVVWVIGLKHADSALTWSGTAIGIIFSFYLLM KATHSLPVGTVYAVFTGLGTAGTVLSEIVLFHEPVGWPKLLLIGVLLIGVIGLKLVTQ DETEEKGGEA*" /label="gdnC CDS" gene 1288845..1289183 /gene="gdnC" /locus_tag="BSU_13090" /old_locus_tag="BSU13090" /label="gdnC gene" CDS 1289183..1289500 /gene="gdnD" /locus_tag="BSU_13100" /old_locus_tag="BSU13100" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10735877, 10931887, 15096624, 28001372" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10735877, 10931887, 15096624, 28001372; Product type t: transporter" /codon_start=1 /transl_table=11 /product="guanidinium efflux transporter subunit" /protein_id="NP_389193.1" /db_xref="EnsemblGenomes-Gn:BSU13100" /db_xref="EnsemblGenomes-Tr:CAB13167" /db_xref="GOA:P49857" /db_xref="InterPro:IPR000390" /db_xref="SubtiList:BG11423" /db_xref="UniProtKB/Swiss-Prot:P49857" /translation="MLHWISLLCAGCLEMAGVALMNQYAKEKSVKWVLLIIVGFAASF SLLSYAMETTPMGTAYAVWTGIGTAGGALIGILFYKEQKDAKRIFFIALILCSAVGLK ILS*" /label="gdnD CDS" gene 1289183..1289500 /gene="gdnD" /locus_tag="BSU_13100" /old_locus_tag="BSU13100" /label="gdnD gene" promotor_-35 1289500..1289503 /Source="Nicolas_upshift_promotors" /id="U1057" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.647352647352647" /psig="0.998001998001998" /xcortree=2582 /SigmaFactorBS="tcagcagttggtttaaaaattctgtcataAATTgatttttat caaatcTTCAGTATAATGGATAAATAgtttagacttacaaagataagagggattattc a" /listShort="purU, NA, proB, proA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1289519..1289538 /Source="Nicolas_upshift_promotors" /id="U1057" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.647352647352647" /psig="0.998001998001998" /xcortree=2582 /SigmaFactorBS="tcagcagttggtttaaaaattctgtcataAATTgatttttat caaatcTTCAGTATAATGGATAAATAgtttagacttacaaagataagagggattattc a" /listShort="purU, NA, proB, proA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1289531 /Source="Nicolas_upshifts" /id="U1057" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.647352647352647" /psig="0.998001998001998" /xcortree=2582 /SigmaFactorBS="tcagcagttggtttaaaaattctgtcataAATTgatttttat caaatcTTCAGTATAATGGATAAATAgtttagacttacaaagataagagggattattc a" /listShort="purU, NA, proB, proA" /GFF_Attribute="listLong" /label="upshifts" CDS 1289571..1290473 /gene="purU" /locus_tag="BSU_13110" /old_locus_tag="BSU13110" /EC_number="3.5.1.10" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8226647, 24108189; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="formyltetrahydrofolate hydrolase" /protein_id="NP_389194.2" /db_xref="EnsemblGenomes-Gn:BSU13110" /db_xref="EnsemblGenomes-Tr:CAB13168" /db_xref="GOA:O34990" /db_xref="InterPro:IPR002376" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR004810" /db_xref="InterPro:IPR036477" /db_xref="SubtiList:BG13237" /db_xref="UniProtKB/Swiss-Prot:O34990" /translation="MKSYMTQRLDEYRDGNEDKGRLLVSCPDQPGIVSAVSAFLFEHG ANIIESNQYTTDPEGGRFFLRIEFDCAGIREKKSSLQAAFASVAEKFDMTWSLTLASE LKRVAIFVSKELHCLHELIWEWQTGNLMAEIAVVISNHEEARELVERLNIPFHYMKAN KDIRAEVEKKQLELLEQYDVDVIVLARYMQILTPDFVSAHPNRIINIHHSFLPAFIGA NPYKRAYERGVKLIGATSHYVTNDLDEGPIIEQDIERVDHRDNAEALKNIGRTIERSV LARAVKWHLEDRVIVHENKTIVFN*" /label="purU CDS" gene 1289571..1290473 /gene="purU" /locus_tag="BSU_13110" /old_locus_tag="BSU13110" /label="purU gene" downshifts 1290464 /Source="Nicolas_upshifts" /id="D714" /incds=0 /nref=91 /ntot=226 /MaxReadThrough="3.55628" /MaxDrop="5.02155" /score="16.8011006" /energy="-13.1" /TU="U1057" /idTUdmin="U1056" /TUdmin=945 /isTUend="FALSE" /label="downshifts" promotor_-35 1290520..1290526 /Source="Nicolas_upshift_promotors" /id="U1058" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.482517482517482" /psig="0.998001998001998" /xcortree=3136 /SigmaFactorBS="agactgcaagaggcccgcgcaatgcgggctatttttgatgac aaaaaaCCTTGACaagtgtcttttttCTTTGCATAATATAAAAAAAtcattgagcgtt g" /listShort="NA, proB, proA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1290532 /Source="Nicolas_upshifts" /id="U1058" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.482517482517482" /psig="0.998001998001998" /xcortree=3136 /SigmaFactorBS="agactgcaagaggcccgcgcaatgcgggctatttttgatgac aaaaaaCCTTGACaagtgtcttttttCTTTGCATAATATAAAAAAAtcattgagcgtt g" /listShort="NA, proB, proA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1290540..1290559 /Source="Nicolas_upshift_promotors" /id="U1058" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.482517482517482" /psig="0.998001998001998" /xcortree=3136 /SigmaFactorBS="agactgcaagaggcccgcgcaatgcgggctatttttgatgac aaaaaaCCTTGACaagtgtcttttttCTTTGCATAATATAAAAAAAtcattgagcgtt g" /listShort="NA, proB, proA" /GFF_Attribute="listLong" /label="promotor_-10" misc_RNA 1290561..1290771 /gene="pswB" /locus_tag="BSU_misc_RNA_17" /product="T-box riboswitch specific of proline tRNA" /experiment="publication(s) with functional evidences, PMID:11917026, 12749771, 19932103, 21233158" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11917026, 12749771, 19932103, 21233158; Product type n: RNA" /function="16.3: Control" /label="pswB RNA" gene 1290561..1290771 /gene="pswB" /locus_tag="BSU_misc_RNA_17" /label="pswB gene" downshifts 1290729 /Source="Nicolas_upshifts" /id="D715" /incds=0 /nref=4 /ntot=52 /MaxReadThrough="6.91996" /MaxDrop="3.8361" /score="29.5878921" /energy="-17.6" /TU="U1057,U1058" /idTUdmin="U1056" /TUdmin=1210 /isTUend="FALSE" /label="downshifts" CDS 1290824..1291921 /gene="proB" /locus_tag="BSU_13120" /old_locus_tag="BSU13120" /EC_number="2.7.2.11" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:16958849, 8083159, 21233158, 21784929" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16958849, 8083159, 21233158, 21784929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamate 5-kinase" /protein_id="NP_389195.2" /db_xref="EnsemblGenomes-Gn:BSU13120" /db_xref="EnsemblGenomes-Tr:CAB13169" /db_xref="GOA:P39820" /db_xref="InterPro:IPR001048" /db_xref="InterPro:IPR001057" /db_xref="InterPro:IPR002478" /db_xref="InterPro:IPR005715" /db_xref="InterPro:IPR011529" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR019797" /db_xref="InterPro:IPR036393" /db_xref="InterPro:IPR036974" /db_xref="SubtiList:BG10963" /db_xref="UniProtKB/Swiss-Prot:P39820" /translation="MKKQRIVVKIGSSSLTNSKGSIDEAKIREHVQAISVLKKAGHEM ILITSGAVAAGFSSLGYPSRPVTIKGKQAAAAVGQTLLMQQYMNQFKQYSLTPGQILL TRNDFSKRERYRNAYATIMELLERGVIPIINENDSTSVEELTFGDNDMLSALVSGLIH ADQLMILTDINGLYDANPNENPEAKRFDYLPEITPELLGYAGSAGSKVGTGGMKSKLL ATQTALSLGVKVFIGTGSGEQKLADILDGRGDGTYIGDKELSSVNNTRQWIQFHSPIS GEIIIDAGAEEAMIHNGSSLLPAGVVGVNGSFPKGAVVEVRGPGGVIGKGQTHYSSEE IMEAKGKRSDELDFEKTFEVIHRNDWVNVKD*" /label="proB CDS" gene 1290824..1291921 /gene="proB" /locus_tag="BSU_13120" /old_locus_tag="BSU13120" /label="proB gene" promotor_-35 1291011..1291013 /Source="Nicolas_upshift_promotors" /id="U1059" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.365634365634366" /psig="0.206793206793207" /xcortree=1776 /SigmaFactorBS="gattctgattacctcgggtgccgtagcggcggggttttccag cctcggttatccatCCCgTCCCGttaccatcaaaggaaaacaggcggcggccgcggtc g" /listShort="proA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1291015..1291019 /Source="Nicolas_upshift_promotors" /id="U1059" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.365634365634366" /psig="0.206793206793207" /xcortree=1776 /SigmaFactorBS="gattctgattacctcgggtgccgtagcggcggggttttccag cctcggttatccatCCCgTCCCGttaccatcaaaggaaaacaggcggcggccgcggtc g" /listShort="proA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1291015 /Source="Nicolas_upshifts" /id="U1059" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.365634365634366" /psig="0.206793206793207" /xcortree=1776 /SigmaFactorBS="gattctgattacctcgggtgccgtagcggcggggttttccag cctcggttatccatCCCgTCCCGttaccatcaaaggaaaacaggcggcggccgcggtc g" /listShort="proA" /GFF_Attribute="listLong" /label="upshifts" CDS 1291933..1293180 /gene="proA" /locus_tag="BSU_13130" /old_locus_tag="BSU13130" /EC_number="1.2.1.41" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:16958849, 8083159, 21784929, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16958849, 8083159, 21784929, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="gamma-glutamyl phosphate reductase" /protein_id="NP_389196.2" /db_xref="EnsemblGenomes-Gn:BSU13130" /db_xref="EnsemblGenomes-Tr:CAB13170" /db_xref="GOA:P39821" /db_xref="InterPro:IPR000965" /db_xref="InterPro:IPR012134" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR020593" /db_xref="SubtiList:BG10964" /db_xref="UniProtKB/Swiss-Prot:P39821" /translation="MSEVSVKAKLAKEAAAEMIMKTTAEKDEALSLIANGLRKELDFL LAENAKDIVNGKENGLTPDIIDRLSLDEKRIRDIADAVELLIDLADPIGDSLETIEKE NGLFIEKIRVPLGVVGMIYEARPNVTVDAATLCLKTGNAVVLRGSSSAIHSNKALVSV IYRALEQSALPIHAVQLIEDTSRETAKELFTLNDGLDVLIPRGGKKLIDLVVRESTVP VLETGAGNCHIFIDETAKPQMAEKVVVNAKTQRPSVCNAIESLLIHKAWARQHGKELL DQLENAGVEIRGDELVCELHPSSKQASKEDWETEFLAPVLSVKTVENVQEAVKHIQQY GTNHSEAILTENDKNAVYFQTAVDAAAVYHNASTRFTDGFEFGYGAEIGISTQKLHAR GPMGLPALTSTKYIIKGTGQIRE*" /label="proA CDS" gene 1291933..1293180 /gene="proA" /locus_tag="BSU_13130" /old_locus_tag="BSU13130" /label="proA gene" downshifts 1293171 /Source="Nicolas_upshifts" /id="D716" /incds=0 /nref=120 /ntot=228 /MaxReadThrough="4.1607" /MaxDrop="6.017" /score="11.118012" /energy="-11" /TU="U1058" /idTUdmin="U1059" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1293242..1293249 /Source="Nicolas_upshift_promotors" /id="U1060" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.947052947052947" /psig=1 /xcortree=3016 /SigmaFactorBS="ttacgagataagcttttttatacgcgaaaAATTGACAtttca aatttaattGTGTACAATTTAATTGTATAaaatatattgggggaatgaaaaatgagtc a" /listShort="ohrA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1293264..1293283 /Source="Nicolas_upshift_promotors" /id="U1060" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.947052947052947" /psig=1 /xcortree=3016 /SigmaFactorBS="ttacgagataagcttttttatacgcgaaaAATTGACAtttca aatttaattGTGTACAATTTAATTGTATAaaatatattgggggaatgaaaaatgagtc a" /listShort="ohrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1293273 /Source="Nicolas_upshifts" /id="U1060" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.947052947052947" /psig=1 /xcortree=3016 /SigmaFactorBS="ttacgagataagcttttttatacgcgaaaAATTGACAtttca aatttaattGTGTACAATTTAATTGTATAaaatatattgggggaatgaaaaatgagtc a" /listShort="ohrA" /GFF_Attribute="listLong" /label="upshifts" CDS 1293306..1293731 /gene="ohrA" /locus_tag="BSU_13140" /old_locus_tag="BSU13140" /EC_number="1.11.1.15" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11418552, 17502599, 21749987, 24184231" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11418552, 17502599, 21749987, 24184231; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peroxiredoxin" /protein_id="NP_389197.1" /db_xref="EnsemblGenomes-Gn:BSU13140" /db_xref="EnsemblGenomes-Tr:CAB13171" /db_xref="GOA:O34762" /db_xref="InterPro:IPR003718" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR019953" /db_xref="InterPro:IPR036102" /db_xref="SubtiList:BG13238" /db_xref="UniProtKB/Swiss-Prot:O34762" /translation="MSQPLFTATVSAVGGREGKVISSDRVLELDVAMPGTPRAKKLEK ATNPEQLFAAGYAACFDSALQLVARTERVKVETEVTANVSLLKDEADQGYKLGVTLQV KGEGVSASELEALVKKAHGVCPYSKATSGNIDVTLEVAE*" /label="ohrA CDS" gene 1293306..1293731 /gene="ohrA" /locus_tag="BSU_13140" /old_locus_tag="BSU13140" /label="ohrA gene" downshifts 1293720 /Source="Nicolas_upshifts" /id="D717" /incds=0 /nref=57 /ntot=174 /MaxReadThrough="0.0429100000000009" /MaxDrop="3.90314" /score="30.9245751" /energy="-16.6" /TU="NA" /idTUdmin="U1060" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1293762..1294205) /gene="ohrR" /locus_tag="BSU_13150" /old_locus_tag="BSU13150" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11983871, 17502599, 18363800, 20094649, 21749987, 24184231" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11983871, 17502599, 18363800, 20094649, 21749987, 24184231; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator sensing organic peroxides" /protein_id="NP_389198.1" /db_xref="EnsemblGenomes-Gn:BSU13150" /db_xref="EnsemblGenomes-Tr:CAB13172" /db_xref="GOA:O34777" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:1Z91" /db_xref="PDB:1Z9C" /db_xref="SubtiList:BG13239" /db_xref="UniProtKB/Swiss-Prot:O34777" /translation="MENKFDHMKLENQLCFLLYASSREMTKQYKPLLDKLNITYPQYL ALLLLWEHETLTVKKMGEQLYLDSGTLTPMLKRMEQQGLITRKRSEEDERSVLISLTE DGALLKEKAVDIPGTILGLSKQSGEDLKQLKSALYTLLETLHQKN*" /label="ohrR CDS" gene complement(1293762..1294205) /gene="ohrR" /locus_tag="BSU_13150" /old_locus_tag="BSU13150" /label="ohrR gene" downshifts complement(1293796) /Source="Nicolas_upshifts" /id="D718" /incds=0 /nref=105 /ntot=232 /MaxReadThrough="-0.17111" /MaxDrop="4.73026" /score="34.7008532" /energy="-16.6" /TU="NA" /idTUdmin="U1061" /TUdmin=1 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1294232..1294251) /Source="Nicolas_upshift_promotors" /id="U1061" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig=1 /xcortree=2020 /SigmaFactorBS="tctttttaaacatgctatgtttgccgagaATAGgaaaagtga ggtttTTCAGATACAATAGAATCGAatgacaaaaaagagttggtgaacaaaatggaaa a" /listShort="ohrR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1294238) /Source="Nicolas_upshifts" /id="U1061" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig=1 /xcortree=2020 /SigmaFactorBS="tctttttaaacatgctatgtttgccgagaATAGgaaaagtga ggtttTTCAGATACAATAGAATCGAatgacaaaaaagagttggtgaacaaaatggaaa a" /listShort="ohrR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1294266..1294269) /Source="Nicolas_upshift_promotors" /id="U1061" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig=1 /xcortree=2020 /SigmaFactorBS="tctttttaaacatgctatgtttgccgagaATAGgaaaagtga ggtttTTCAGATACAATAGAATCGAatgacaaaaaagagttggtgaacaaaatggaaa a" /listShort="ohrR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1294287..1294293 /Source="Nicolas_upshift_promotors" /id="U1062" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=232 /SigmaFactorBS="aacctcacttttcctattctcggcaaacatagcaTGTTTAAa aagatcagaaagGGAAATATAACAACTAGATacaaataaggaggttgggaaatatggc a" /listShort="ohrB, ykzN, S468" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1294307..1294325 /Source="Nicolas_upshift_promotors" /id="U1062" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=232 /SigmaFactorBS="aacctcacttttcctattctcggcaaacatagcaTGTTTAAa aagatcagaaagGGAAATATAACAACTAGATacaaataaggaggttgggaaatatggc a" /listShort="ohrB, ykzN, S468" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1294313 /Source="Nicolas_upshifts" /id="U1062" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=232 /SigmaFactorBS="aacctcacttttcctattctcggcaaacatagcaTGTTTAAa aagatcagaaagGGAAATATAACAACTAGATacaaataaggaggttgggaaatatggc a" /listShort="ohrB, ykzN, S468" /GFF_Attribute="listLong" /label="upshifts" CDS 1294348..1294758 /gene="ohrB" /locus_tag="BSU_13160" /old_locus_tag="BSU13160" /EC_number="1.11.1.15" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9696771, 11418552, 18084074" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9696771, 11418552, 18084074; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="organic hydroperoxide resistance reductase B" /protein_id="NP_389199.1" /db_xref="EnsemblGenomes-Gn:BSU13160" /db_xref="EnsemblGenomes-Tr:CAB13173" /db_xref="GOA:P80242" /db_xref="InterPro:IPR003718" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR019953" /db_xref="InterPro:IPR036102" /db_xref="PDB:2BJO" /db_xref="SubtiList:BG19021" /db_xref="UniProtKB/Swiss-Prot:P80242" /translation="MALFTAKVTARGGRAGHITSDDGVLDFDIVMPNAKKEGQTGTNP EQLFAAGYAACFGGALEHVAKEQNIEIDSEIEGQVSLMKDESDGGFKIGVTLVVNTKD LDREKAQELVNAAHEFCPYSKATRGNVDVKLELK*" /label="ohrB CDS" gene 1294348..1294758 /gene="ohrB" /locus_tag="BSU_13160" /old_locus_tag="BSU13160" /label="ohrB gene" downshifts 1294736 /Source="Nicolas_upshifts" /id="D719" /incds=0 /nref=7 /ntot=145 /MaxReadThrough="8.17185" /MaxDrop="4.0663" /score="17.6512157" /energy="-12.1" /TU="U1062" /idTUdmin="U1062" /TUdmin="-855" /isTUend="FALSE" /label="downshifts" CDS 1294785..1294955 /gene="ykzN" /locus_tag="BSU_13169" /old_locus_tag="BSU13169" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097717.1" /db_xref="EnsemblGenomes-Gn:BSU13169" /db_xref="EnsemblGenomes-Tr:CAX52607" /db_xref="UniProtKB/Swiss-Prot:C0H400" /translation="MFFGVGHAGRAQIYDKTSEKRLKHAFKPKVTDEAGGWHGVCRAE LRVYAVLYLHRA*" /label="ykzN CDS" gene 1294785..1294955 /gene="ykzN" /locus_tag="BSU_13169" /old_locus_tag="BSU13169" /label="ykzN gene" S_feature 1294956..1295633 /Source="Nicolas_S_feature" /locus_tag="new_1382628_1383305" /HighExp="Etha, Salt, M9-stat, Sw, B60, LPhT, B36, Heat, Gly, BC" /AntisenseName="guaD" /AntisenseCor="-5.7732597431508298E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S468" CDS complement(1295005..1295475) /gene="guaN" /locus_tag="BSU_13170" /old_locus_tag="BSU13170" /EC_number="3.5.4.3" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11101664, 15180998" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11101664, 15180998; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="guanine deaminase" /protein_id="NP_389200.1" /db_xref="EnsemblGenomes-Gn:BSU13170" /db_xref="EnsemblGenomes-Tr:CAB13174" /db_xref="GOA:O34598" /db_xref="InterPro:IPR002125" /db_xref="InterPro:IPR016192" /db_xref="InterPro:IPR016193" /db_xref="PDB:1TIY" /db_xref="PDB:1WKQ" /db_xref="SubtiList:BG13240" /db_xref="UniProtKB/Swiss-Prot:O34598" /translation="MNHETFLKRAVTLACEGVNAGIGGPFGAVIVKDGAIIAEGQNNV TTSNDPTAHAEVTAIRKACKVLGAYQLDDCILYTSCEPCPMCLGAIYWARPKAVFYAA EHTDAAEAGFDDSFIYKEIDKPAEERTIPFYQVTLTEHLSPFQAWRNFANKKEY*" /label="guaN CDS" gene complement(1295005..1295475) /gene="guaN" /locus_tag="BSU_13170" /old_locus_tag="BSU13170" /label="guaN gene" downshifts complement(1295029) /Source="Nicolas_upshifts" /id="D720" /incds=0 /nref=25 /ntot=112 /MaxReadThrough="0.698199999999999" /MaxDrop="4.30578" /score="-6.41557266" /energy="-13.5" /TU="NA" /idTUdmin="U1063" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1295497..1295516) /Source="Nicolas_upshift_promotors" /id="U1063" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.434565434565435" /psig="0.933066933066933" /xcortree=790 /SigmaFactorBS="atcccccaaatactttgtttattttgcacttttttaagAATG ttctttgcattctttTCGGCTATACTAATAACACTctattgacaggagggattgggat g" /listShort="guaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1295513) /Source="Nicolas_upshifts" /id="U1063" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.434565434565435" /psig="0.933066933066933" /xcortree=790 /SigmaFactorBS="atcccccaaatactttgtttattttgcacttttttaagAATG ttctttgcattctttTCGGCTATACTAATAACACTctattgacaggagggattgggat g" /listShort="guaD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1295515..1295622) /Source="Nicolas_S_feature" /locus_tag="new_1383187_1383294_c" /HighExp="BMM, MG 10, MG 15, MG 5, MG t5, GM 25, B36, Gly, B60, GM 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.044, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S469" promotor_-35 complement(1295532..1295535) /Source="Nicolas_upshift_promotors" /id="U1063" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.434565434565435" /psig="0.933066933066933" /xcortree=790 /SigmaFactorBS="atcccccaaatactttgtttattttgcacttttttaagAATG ttctttgcattctttTCGGCTATACTAATAACACTctattgacaggagggattgggat g" /listShort="guaD" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1295591 /Source="Nicolas_upshifts" /id="D721" /incds=0 /nref=9 /ntot=34 /MaxReadThrough="0.95942" /MaxDrop="5.95076" /score="15.2916843" /energy="-11.5" /TU="NA" /idTUdmin="U1062" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1295648..1297936) /gene="metE" /locus_tag="BSU_13180" /old_locus_tag="BSU13180" /EC_number="2.1.1.14" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8755891, 10094622, 12910260, 16086852, 16194229, 17012790, 17611193, 21749987, 22938038, 24313874" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8755891, 10094622, 12910260, 16086852, 16194229, 17012790, 17611193, 21749987, 22938038, 24313874; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cobalamin-independent methionine synthase" /protein_id="NP_389201.2" /db_xref="EnsemblGenomes-Gn:BSU13180" /db_xref="EnsemblGenomes-Tr:CAB13175" /db_xref="GOA:P80877" /db_xref="InterPro:IPR002629" /db_xref="InterPro:IPR006276" /db_xref="InterPro:IPR013215" /db_xref="SubtiList:BG12616" /db_xref="UniProtKB/Swiss-Prot:P80877" /translation="MTTIKTSNLGFPRIGLNREWKKALEAYWKGSTDKDTFLKQIDEL FLSAVKTQIDQQIDVVPVSDFTQYDHVLDTAVSFNWIPKRFRHLTDATDTYFAIARGI KDAVSSEMTKWFNTNYHYIVPEYDESIEFRLTRNKQLEDYRRIKQEYGVETKPVIVGP YTFVTLAKGYEPSEAKAIQKRLVPLYVQLLKELEEEGVKWVQIDEPALVTASSEDVRG AKELFESITSELSSLNVLLQTYFDSVDAYEELISYPVQGIGLDFVHDKGRNLEQLKTH GFPTDKVLAAGVIDGRNIWKADLEERLDAVLDILSIAKVDELWIQPSSSLLHVPVAKH PDEHLEKDLLNGLSYAKEKLAELTALKEGLVSGKAAISEEIQQAKADIQALKQFATGA NSEQKKELEQLTDKDFKRPIPFEERLALQNESLGLPLLPTTTIGSFPQSAEVRSARQK WRKAEWSDEQYQNFINAETKRWIDIQEELELDVLVHGEFERTDMVEYFGEKLAGFAFT KYAWVQSYGSRCVRPPVIYGDVEFIEPMTVKDTVYAQSLTSKHVKGMLTGPVTILNWS FPRNDISRKEIAFQIGLALRKEVKALEDAGIQIIQVDEPALREGLPLKTRDWDEYLTW AAEAFRLTTSSVKNETQIHTHMCYSNFEDIVDTINDLDADVITIEHSRSHGGFLDYLK NHPYLKGLGLGVYDIHSPRVPSTEEMYNIIVDALAVCPTDRFWVNPDCGLKTRQQEET VAALKNMVEAAKQARAQQTQLV*" /label="metE CDS" gene complement(1295648..1297936) /gene="metE" /locus_tag="BSU_13180" /old_locus_tag="BSU13180" /label="metE gene" downshifts complement(1295667) /Source="Nicolas_upshifts" /id="D722" /incds=0 /nref=212 /ntot=239 /MaxReadThrough="5.25958" /MaxDrop="7.50935" /score="29.3354648" /energy="-11.5" /TU="U1064,U1065" /idTUdmin="U1063" /TUdmin="-638" /isTUend="FALSE" /label="downshifts" S_feature complement(1297937..1297999) /Source="Nicolas_S_feature" /locus_tag="new_1385609_1385671_c" /HighExp="MG 15, MG 5, MG t5, BMM, T-1.40H, MG 25, MG 10, GM 25, Mal, Etha" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, SigA" /TUshortPSig="0.044, 1, 0.587" /TUlongSig="NA" /TUlongPSig="NA" /label="S470" promotor_no_box complement(1297959..1298059) /Source="Nicolas_upshift_promotors" /id="U1064" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.332667332667333" /psig="0.043956043956044" /xcortree=3023 /SigmaFactorBS="agtgttttacgtagaaaagcctctttctctcatgggaaagag gctttttgttgtgagaaaacctcttagcagcctgtatccgcgggtgaaagagagtgtt t" /listShort="S470, metE, S469, guaD" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1297999) /Source="Nicolas_upshifts" /id="U1064" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.332667332667333" /psig="0.043956043956044" /xcortree=3023 /SigmaFactorBS="agtgttttacgtagaaaagcctctttctctcatgggaaagag gctttttgttgtgagaaaacctcttagcagcctgtatccgcgggtgaaagagagtgtt t" /listShort="S470, metE, S469, guaD" /GFF_Attribute="listLong" /label="upshifts" misc_RNA complement(1298064..1298219) /gene="mswB" /locus_tag="BSU_misc_RNA_18" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762, 22543867" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762, 22543867; Product type n : RNA" /function="16.3: Control" /label="mswB RNA" gene complement(1298064..1298219) /gene="mswB" /locus_tag="BSU_misc_RNA_18" /label="mswB gene" downshifts complement(1298065) /Source="Nicolas_upshifts" /id="D723" /incds=0 /nref=55 /ntot=106 /MaxReadThrough="8.12248" /MaxDrop="6.4813" /score="24.0596293" /energy="-16.2" /TU="U1065,U1066" /idTUdmin="U1066" /TUdmin="-308" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1298252..1298271) /Source="Nicolas_upshift_promotors" /id="U1065" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2888 /SigmaFactorBS="acatcatgtaaataaaaatttcaaattctaTGTTGACAatga atttgaattacTGTTAAGATTACCAACAAATgattcaacttttcaaaaaattaataac a" /listShort="NA, S470, metE, S469, guaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1298264) /Source="Nicolas_upshifts" /id="U1065" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2888 /SigmaFactorBS="acatcatgtaaataaaaatttcaaattctaTGTTGACAatga atttgaattacTGTTAAGATTACCAACAAATgattcaacttttcaaaaaattaataac a" /listShort="NA, S470, metE, S469, guaD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1298266..1298351) /Source="Nicolas_S_feature" /locus_tag="new_1385938_1386023_c" /HighExp="BT, BC, B36, M9-stat, T5.0H, S3, S6, T4.0H, S5, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.587" /TUlongSig="NA" /TUlongPSig="NA" /label="S471" promotor_-35 complement(1298287..1298294) /Source="Nicolas_upshift_promotors" /id="U1065" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2888 /SigmaFactorBS="acatcatgtaaataaaaatttcaaattctaTGTTGACAatga atttgaattacTGTTAAGATTACCAACAAATgattcaacttttcaaaaaattaataac a" /listShort="NA, S470, metE, S469, guaD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1298352..1299311) /gene="ispA" /locus_tag="BSU_13190" /old_locus_tag="BSU13190" /EC_number="3.4.21.-" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:3087947, 14680823, 23569278" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3087947, 14680823, 23569278; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="intracellular serine protease" /protein_id="NP_389202.1" /db_xref="EnsemblGenomes-Gn:BSU13190" /db_xref="EnsemblGenomes-Tr:CAB13176" /db_xref="GOA:P11018" /db_xref="InterPro:IPR000209" /db_xref="InterPro:IPR015500" /db_xref="InterPro:IPR022398" /db_xref="InterPro:IPR023827" /db_xref="InterPro:IPR023828" /db_xref="InterPro:IPR034202" /db_xref="InterPro:IPR036852" /db_xref="SubtiList:BG10674" /db_xref="UniProtKB/Swiss-Prot:P11018" /translation="MNGEIRLIPYVTNEQIMDVNELPEGIKVIKAPEMWAKGVKGKNI KVAVLDTGCDTSHPDLKNQIIGGKNFTDDDGGKEDAISDYNGHGTHVAGTIAANDSNG GIAGVAPEASLLIVKVLGGENGSGQYEWIINGINYAVEQKVDIISMSLGGPSDVPELK EAVKNAVKNGVLVVCAAGNEGDGDERTEELSYPAAYNEVIAVGSVSVARELSEFSNAN KEIDLVAPGENILSTLPNKKYGKLTGTSMAAPHVSGALALIKSYEEESFQRKLSESEV FAQLIRRTLPLDIAKTLAGNGFLYLTAPDELAEKAEQSHLLTL*" /label="ispA CDS" gene complement(1298352..1299311) /gene="ispA" /locus_tag="BSU_13190" /old_locus_tag="BSU13190" /label="ispA gene" S_feature complement(1299312..1299363) /Source="Nicolas_S_feature" /locus_tag="new_1386984_1387035_c" /HighExp="BT, B36, BC, T5.0H, M9-stat, T0.30H, T3.30H, T3.0H, T4.0H, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.587" /TUlongSig="NA" /TUlongPSig="NA" /label="S472" promotor_-10 complement(1299356..1299375) /Source="Nicolas_upshift_promotors" /id="U1066" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.358641358641359" /psig="0.587412587412587" /xcortree=465 /SigmaFactorBS="tgtatcctattttttcaaaatgcttcaaatggcTCTGTCCga gcgcttgctttTTTCATATAATATGAGGCAAcacccttgaatccacttgcaagcataa a" /listShort="S472, ispA, S471, NA, S470, metE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1299368) /Source="Nicolas_upshifts" /id="U1066" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.358641358641359" /psig="0.587412587412587" /xcortree=465 /SigmaFactorBS="tgtatcctattttttcaaaatgcttcaaatggcTCTGTCCga gcgcttgctttTTTCATATAATATGAGGCAAcacccttgaatccacttgcaagcataa a" /listShort="S472, ispA, S471, NA, S470, metE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1299389..1299395) /Source="Nicolas_upshift_promotors" /id="U1066" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.358641358641359" /psig="0.587412587412587" /xcortree=465 /SigmaFactorBS="tgtatcctattttttcaaaatgcttcaaatggcTCTGTCCga gcgcttgctttTTTCATATAATATGAGGCAAcacccttgaatccacttgcaagcataa a" /listShort="S472, ispA, S471, NA, S470, metE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1299480..1299483 /Source="Nicolas_upshift_promotors" /id="U1067" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.3996003996004" /psig=1 /xcortree=2359 /SigmaFactorBS="gaattagtaatcttcaaaatattggatggcttcaacatgtat gaCTGGgattcaactgtaagtCAAGTTATAATAGTGTTGGGgaaaggagcagtgtcat g" /listShort="rsbRB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1299496 /Source="Nicolas_upshifts" /id="U1067" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.3996003996004" /psig=1 /xcortree=2359 /SigmaFactorBS="gaattagtaatcttcaaaatattggatggcttcaacatgtat gaCTGGgattcaactgtaagtCAAGTTATAATAGTGTTGGGgaaaggagcagtgtcat g" /listShort="rsbRB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1299499..1299518 /Source="Nicolas_upshift_promotors" /id="U1067" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.3996003996004" /psig=1 /xcortree=2359 /SigmaFactorBS="gaattagtaatcttcaaaatattggatggcttcaacatgtat gaCTGGgattcaactgtaagtCAAGTTATAATAGTGTTGGGgaaaggagcagtgtcat g" /listShort="rsbRB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1299534..1300367 /gene="rsbRB" /locus_tag="BSU_13200" /old_locus_tag="BSU13200" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15312768, 15583165, 17158665" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15312768, 15583165, 17158665; Product type f: factor" /codon_start=1 /transl_table=11 /product="component of the anxiosome (stressosome)" /protein_id="NP_389203.1" /db_xref="EnsemblGenomes-Gn:BSU13200" /db_xref="EnsemblGenomes-Tr:CAB13177" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR036513" /db_xref="SubtiList:BG12609" /db_xref="UniProtKB/Swiss-Prot:O34860" /translation="MKLNEKLYAFFSEHVEQMAEEWIETMEESDPNSLYALHNATVTE ELKEQDREFYRHLNYMYVLPEKQFLEEFQEWVIELTNDQKHLDTPVQYVIREFMRNRR LYTKYFEKFAEENESAFEPGEKQKWADLIVKVFDFTIYTFVDHAEMNAKQQLNAQREM ILELSSPVITLSKSTALLPLVGDIDTERAKFILENTLQACAKRRVEHLLIDLSGVVVV DTMVAHQIFKLIEALNLIGVRSTLSGIRPEIAQTAVQLGIDFSNITIKTNLAQALNYH Q*" /label="rsbRB CDS" gene 1299534..1300367 /gene="rsbRB" /locus_tag="BSU_13200" /old_locus_tag="BSU13200" /label="rsbRB gene" downshifts 1300343 /Source="Nicolas_upshifts" /id="D724" /incds=0 /nref=219 /ntot=254 /MaxReadThrough="3.01586" /MaxDrop="6.07238" /score="22.2655638" /energy="-12.1" /TU="NA" /idTUdmin="U1067" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1300398..1301162) /gene="thiX" /locus_tag="BSU_13210" /old_locus_tag="BSU13210" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16291685, 16356850, 16850406, 18931129" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16291685, 16356850, 16850406, 18931129; Product type t : transporter" /codon_start=1 /transl_table=11 /product="thiamine transporter, transmembrane T component" /protein_id="NP_389204.1" /db_xref="EnsemblGenomes-Gn:BSU13210" /db_xref="EnsemblGenomes-Tr:CAB13178" /db_xref="GOA:O34572" /db_xref="InterPro:IPR003339" /db_xref="SubtiList:BG13248" /db_xref="UniProtKB/Swiss-Prot:O34572" /translation="MKQPLHLINPTVKAAAVFCCVVMLSFIYNPYTPACFYIIIVAGV LLAAGIPLKKWLLFTIPFLILAFGCVWTAAVFGKVPTTPDNFLFQAGPISINSDNVSV GISLGFRILCFSALSMMFVFTTDPILFMLSLVQQCRLSPKLAYGVIAGFRFLPLLKDE VQLIQQAHKIRGGAAESGIINKISALKRYTIPLLASAIRKAERTALAMESKGFTGSRN RTYYRTLSVNRRDWVFFCLVLLLFAGSFLVSLCFAS*" /label="thiX CDS" gene complement(1300398..1301162) /gene="thiX" /locus_tag="BSU_13210" /old_locus_tag="BSU13210" /label="thiX gene" downshifts complement(1300419) /Source="Nicolas_upshifts" /id="D725" /incds=0 /nref=143 /ntot=164 /MaxReadThrough="0.824010000000001" /MaxDrop="6.67697" /score="34.7739353" /energy="-12.1" /TU="NA" /idTUdmin="U1069" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1301137..1302780) /gene="thiW" /locus_tag="BSU_13220" /old_locus_tag="BSU13220" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16291685, 16356850, 16850406, 18931129" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16291685, 16356850, 16850406, 18931129; Product type t : transporter" /codon_start=1 /transl_table=11 /product="thiamine ABC transporter (ATP-binding subunit)" /protein_id="NP_389205.2" /db_xref="EnsemblGenomes-Gn:BSU13220" /db_xref="EnsemblGenomes-Tr:CAB13179" /db_xref="GOA:O34362" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13249" /db_xref="UniProtKB/Swiss-Prot:O34362" /translation="MQAFDELLTVEQLSFSYEEDEKPVFQDISFELQKGECVLLLGPS GCGKSSLALCLNGLYPEACDGIQSGHVFLFQKPVTDAETSETITQHAGVVFQDPDQQF CMLTVEDEIAFGLENLQIPKEEMTEKINAVLEKLRITHLKEKMISTLSGGQKQKVALA CILAMEPELIILDEPTSLLDPFSAREFVHLMKDLQREKGFSLLVIEHQLDEWAPWIER TIVLDKSGKKALDGLTKNLFQHEAETLKKLGIAIPKVCHLQEKLSMPFTLSKEMLFKE PIPAGHVKKKKAPSGESVLEVSSLSFARGQQAIFKDISFSLREGSLTALVGPNGTGKS TLLSVLASLMKPQSGKILLYDQPLQKYKEKELRKRMGFVFQNPEHQFVTDTVYDELLF GQKANAETEKKAQHLLQRFGLAHLADHHPFAISQGQKRRLSVATMLMHDVKVLLLDEP TFGQDARTAAECMEMIQRIKAEGTAVLMITHDMELVSSYADSVLVLHDTGLAFDGSPA QLFSQETGLVQKAKLTLPLLYEWMAFQEEVRDEATVTSH*" /label="thiW CDS" gene complement(1301137..1302780) /gene="thiW" /locus_tag="BSU_13220" /old_locus_tag="BSU13220" /label="thiW gene" CDS complement(1302767..1303366) /gene="thiV" /locus_tag="BSU_13230" /old_locus_tag="BSU13230" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16291685, 16356850, 16850406, 27447050, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16291685, 16356850, 16850406, 27447050, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="thiamine transporter, permease component" /protein_id="NP_389206.2" /db_xref="EnsemblGenomes-Gn:BSU13230" /db_xref="EnsemblGenomes-Tr:CAB13180" /db_xref="GOA:O34738" /db_xref="InterPro:IPR017195" /db_xref="PDB:5EDL" /db_xref="SubtiList:BG13250" /db_xref="UniProtKB/Swiss-Prot:O34738" /translation="MKSWKVKEIVIMSVISIVFAVVYLLFTHFGNVLAGMFGPIAYEP IYGIWFIVSVIAAYMIRKPGAALVSEIIAALVECLLGNPSGPMVIVIGIVQGLGAEAV FLATRWKAYSLPVLMLAGMGSSVASFIYDLFVSGYAAYSPGYLLIMLVIRLISGALLA GLLGKAVSDSLAYTGVLNGMALGKELKKKRKRASEHASL*" /label="thiV CDS" gene complement(1302767..1303366) /gene="thiV" /locus_tag="BSU_13230" /old_locus_tag="BSU13230" /label="thiV gene" CDS complement(1303368..1303970) /gene="thiU" /locus_tag="BSU_13240" /old_locus_tag="BSU13240" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15451668, 16291685, 16356850, 20471400" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15451668, 16291685, 16356850, 20471400; Product type f: factor" /codon_start=1 /transl_table=11 /product="thiamine-binding protein (oxidation stress protein)" /protein_id="NP_389207.1" /db_xref="EnsemblGenomes-Gn:BSU13240" /db_xref="EnsemblGenomes-Tr:CAB13181" /db_xref="GOA:O34911" /db_xref="InterPro:IPR011522" /db_xref="InterPro:IPR015835" /db_xref="InterPro:IPR029756" /db_xref="PDB:1S7H" /db_xref="PDB:1S99" /db_xref="PDB:1SBR" /db_xref="SubtiList:BG13251" /db_xref="UniProtKB/Swiss-Prot:O34911" /translation="MEHICGTSRIAGFRFSLYPMTDDFISVIKSALKKTDTSKVWTKT DHISTVLRGSIDHVFDAAKAIYLHAANSEQHIVMNGTFSIGCPGDTQGDTYLSKGDKR VNEDAVRGLKAEAPCQFALYPMNEPDYMGLIMEAVDIAKAQGTFVQGVHYASELDGDA HDVFSTLEAVFRMAEQQTNHITMTVNLSANSPSRKNRKQG*" /label="thiU CDS" gene complement(1303368..1303970) /gene="thiU" /locus_tag="BSU_13240" /old_locus_tag="BSU13240" /label="thiU gene" downshifts complement(1304048) /Source="Nicolas_upshifts" /id="D726" /incds=0 /nref=28 /ntot=88 /MaxReadThrough="7.47395" /MaxDrop="5.73297" /score="19.7469386" /energy="-10.9" /TU="U1069" /idTUdmin="U1069" /TUdmin="-3629" /isTUend="FALSE" /label="downshifts" misc_RNA complement(1304067..1304179) /gene="tswB" /locus_tag="BSU_misc_RNA_19" /product="thiamine pyrophosphate riboswitch" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11470904, 12410317, 15862294, 16728979, 16962976, 17307816, 18179415, 18776013; Product type n: RNA" /function="16.3: Control" /label="tswB RNA" gene complement(1304067..1304179) /gene="tswB" /locus_tag="BSU_misc_RNA_19" /label="tswB gene" promotor_-35 1304180..1304183 /Source="Nicolas_upshift_promotors" /id="U1068" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.425574425574426" /psig="0.987012987012987" /xcortree=1848 /SigmaFactorBS="tcagccaaaacagcacccctagtgctttccGTATacaatttt ttattttGACATCATAATAGATGATAAgaatcattttgtaaacaacgaaatcattttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1304194..1304213) /Source="Nicolas_upshift_promotors" /id="U1069" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.917082917082917" /psig=1 /xcortree=2882 /SigmaFactorBS="accatcctctcccgtccctatatgaaaaaaatgatttcgtTG TTTACAaaatgattcttatcATCTATTATGATGTCAAAATaaaaaattgtatacggaa a" /listShort="NA, thiU, thiV, thiW, thiX" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 1304199..1304218 /Source="Nicolas_upshift_promotors" /id="U1068" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.425574425574426" /psig="0.987012987012987" /xcortree=1848 /SigmaFactorBS="tcagccaaaacagcacccctagtgctttccGTATacaatttt ttattttGACATCATAATAGATGATAAgaatcattttgtaaacaacgaaatcattttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1304210 /Source="Nicolas_upshifts" /id="U1068" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.425574425574426" /psig="0.987012987012987" /xcortree=1848 /SigmaFactorBS="tcagccaaaacagcacccctagtgctttccGTATacaatttt ttattttGACATCATAATAGATGATAAgaatcattttgtaaacaacgaaatcattttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1304215) /Source="Nicolas_upshifts" /id="U1069" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.917082917082917" /psig=1 /xcortree=2882 /SigmaFactorBS="accatcctctcccgtccctatatgaaaaaaatgatttcgtTG TTTACAaaatgattcttatcATCTATTATGATGTCAAAATaaaaaattgtatacggaa a" /listShort="NA, thiU, thiV, thiW, thiX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1304228..1304235) /Source="Nicolas_upshift_promotors" /id="U1069" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.917082917082917" /psig=1 /xcortree=2882 /SigmaFactorBS="accatcctctcccgtccctatatgaaaaaaatgatttcgtTG TTTACAaaatgattcttatcATCTATTATGATGTCAAAATaaaaaattgtatacggaa a" /listShort="NA, thiU, thiV, thiW, thiX" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1304281..1304967 /gene="ykoG" /locus_tag="BSU_13250" /old_locus_tag="BSU13250" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YkoH]" /protein_id="NP_389208.1" /db_xref="EnsemblGenomes-Gn:BSU13250" /db_xref="EnsemblGenomes-Tr:CAB13182" /db_xref="GOA:O34903" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG13252" /db_xref="UniProtKB/Swiss-Prot:O34903" /translation="MEKGHILIVEDEEKIARVLQLELEYEGYSVTIKHNGTEGLDAAA EGGYSLVLLDVMLPGLSGLEVLRRLRKTDSQTPVILLTARDSIPDKVTGLDIGANDYV TKPFEIEELLARIRAALRQNGTKTEDIGTFLTYDDLRVNEKTREVRRGDKEVELTPRE FDLLVYMLKHPQQVLTREQILSSVWGFDYIGDTNVVDVYIRYIRKKLDYPYEKQLIHT IRGVGYAIKG*" /label="ykoG CDS" gene 1304281..1304967 /gene="ykoG" /locus_tag="BSU_13250" /old_locus_tag="BSU13250" /label="ykoG gene" CDS 1304971..1306335 /gene="ykoH" /locus_tag="BSU_13260" /old_locus_tag="BSU13260" /EC_number="2.7.13.3" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YkoG]" /protein_id="NP_389209.1" /db_xref="EnsemblGenomes-Gn:BSU13260" /db_xref="EnsemblGenomes-Tr:CAB13183" /db_xref="GOA:O34638" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG13253" /db_xref="UniProtKB/Swiss-Prot:O34638" /translation="MKLKTKIHLYTSISLLILLILVHTAVYLIFSSALTSKDAARLAD ETDNIAEALRAAETEGVALQDMLQAYLPANGMVRVVNGDQKAVMTITKEKAYKDFPLS FHSGETADVRKPDGKLFAEAAVPVIWTDGQVVSLQLVERLENTEESLFLLKIILIAAS AAVCIASFFAGSLLARRIINPIRRLMITMKDIQRDKEFKTISLEGQSNDELYQMGLTF NEMAMMLKEHYDKQQQFVQDASHELKTPLTIIESYSSLMKRWGAKKPEVLEESIEAIH SEAVHMKKLTNQLLALAKSHQGLEVDLKTIDLIKAARAVMQTLQSVYQRDILLETDKE SLLVKADEERIKQLLTILLDNAIKYSEKPIEMSAGTRNGRPFLSVRDEGIGIPEEHIP HLFERFYRADEARNRKTGGTGLGLSIAKQIADEHGIELSVKSKPGQGTAVTMQFSEQN GGGR*" /label="ykoH CDS" gene 1304971..1306335 /gene="ykoH" /locus_tag="BSU_13260" /old_locus_tag="BSU13260" /label="ykoH gene" CDS 1306332..1307012 /gene="ykoI" /locus_tag="BSU_13270" /old_locus_tag="BSU13270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11717295; Product type m : membranecomponent" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="NP_389210.1" /db_xref="EnsemblGenomes-Gn:BSU13270" /db_xref="EnsemblGenomes-Tr:CAB13184" /db_xref="GOA:O34551" /db_xref="InterPro:IPR014722" /db_xref="InterPro:IPR025711" /db_xref="SubtiList:BG13254" /db_xref="UniProtKB/Swiss-Prot:O34551" /translation="MTKTIKTVSFAAAAILVVIICTFLIIRQTHENVLSKETVVKKVE ASYEGKVTKATQSKDKKTYDITLENPKGTYFVKADAISADILSMNRVKAVNPSAMTEK EAEHLALERVPGTVKKQTRQSQVATYTIQKEDGKTYEVKVDMQAKTVLSADQISSKDQ QKTPITKKEAKTIAERKTGGTADDADLEESEGTLIFEVDVDLPDNKEATVKINAYTGK VANIVYED*" /label="ykoI CDS" gene 1306332..1307012 /gene="ykoI" /locus_tag="BSU_13270" /old_locus_tag="BSU13270" /label="ykoI gene" promotor_-35 1307041..1307046 /Source="Nicolas_upshift_promotors" /id="U1070" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.352647352647353" /psig="0.748251748251748" /xcortree=658 /SigmaFactorBS="aagactgacggtttctcatcaaattctcatcttgctCTCGTT ttcctttcatgttgaGTATGTAAACTGTACTCATacaaaacaaaggagggctcacaaa t" /listShort="ykoJ, ykzD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1307062..1307080 /Source="Nicolas_upshift_promotors" /id="U1070" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.352647352647353" /psig="0.748251748251748" /xcortree=658 /SigmaFactorBS="aagactgacggtttctcatcaaattctcatcttgctCTCGTT ttcctttcatgttgaGTATGTAAACTGTACTCATacaaaacaaaggagggctcacaaa t" /listShort="ykoJ, ykzD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1307065 /Source="Nicolas_upshifts" /id="U1070" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.352647352647353" /psig="0.748251748251748" /xcortree=658 /SigmaFactorBS="aagactgacggtttctcatcaaattctcatcttgctCTCGTT ttcctttcatgttgaGTATGTAAACTGTACTCATacaaaacaaaggagggctcacaaa t" /listShort="ykoJ, ykzD" /GFF_Attribute="listLong" /label="upshifts" CDS 1307104..1307616 /gene="ykoJ" /locus_tag="BSU_13280" /old_locus_tag="BSU13280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17209068; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_389211.1" /db_xref="EnsemblGenomes-Gn:BSU13280" /db_xref="EnsemblGenomes-Tr:CAB13185" /db_xref="InterPro:IPR025711" /db_xref="SubtiList:BG13255" /db_xref="UniProtKB/Swiss-Prot:O35012" /translation="MLKKKWMVGLLAGCLAAGGFSYNAFATENNENRQASSKTDALTE QEAEAIAKTVVDGTVEDIDRDLYNGKEVYEVEIEKEGEDYDVYVDIHTKQALNDPLKE KAEQVAITKEEAEEIALKQTGGTVTESKLDEDDGAYIYEMEIQTKQGTETEFEISAKD GRIIKQEIDD*" /label="ykoJ CDS" gene 1307104..1307616 /gene="ykoJ" /locus_tag="BSU_13280" /old_locus_tag="BSU13280" /label="ykoJ gene" downshifts 1307602 /Source="Nicolas_upshifts" /id="D727" /incds=0 /nref=52 /ntot=228 /MaxReadThrough="3.74302" /MaxDrop="6.03059" /score="28.1760649" /energy="-13.7" /TU="U1070" /idTUdmin="U1070" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" promotor_-35 1307647..1307653 /Source="Nicolas_upshift_promotors" /id="U1071" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=922 /SigmaFactorBS="gatgactaatcaaaacccccgctgcagcgggggtttttcATG ATAAgaaaccttcttttGGACAATCTAAGtagaaaaggaggcgaaacgcatggaaaag a" /listShort="ykzD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1307667..1307678 /Source="Nicolas_upshift_promotors" /id="U1071" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=922 /SigmaFactorBS="gatgactaatcaaaacccccgctgcagcgggggtttttcATG ATAAgaaaccttcttttGGACAATCTAAGtagaaaaggaggcgaaacgcatggaaaag a" /listShort="ykzD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1307668 /Source="Nicolas_upshifts" /id="U1071" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=922 /SigmaFactorBS="gatgactaatcaaaacccccgctgcagcgggggtttttcATG ATAAgaaaccttcttttGGACAATCTAAGtagaaaaggaggcgaaacgcatggaaaag a" /listShort="ykzD" /GFF_Attribute="listLong" /label="upshifts" CDS 1307699..1307836 /gene="ykzD" /locus_tag="BSU_13290" /old_locus_tag="BSU13290" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389212.1" /db_xref="EnsemblGenomes-Gn:BSU13290" /db_xref="EnsemblGenomes-Tr:CAB13186" /db_xref="InterPro:IPR022608" /db_xref="SubtiList:BG13332" /db_xref="UniProtKB/Swiss-Prot:O34405" /translation="MEKKEEQYINQAEYVPHPTKEGEYALFLHETYHLLSEDDETQTT E*" /label="ykzD CDS" gene 1307699..1307836 /gene="ykzD" /locus_tag="BSU_13290" /old_locus_tag="BSU13290" /label="ykzD gene" downshifts 1307809 /Source="Nicolas_upshifts" /id="D728" /incds=0 /nref=7 /ntot=31 /MaxReadThrough="1.81189" /MaxDrop="3.56977" /score="-4.52149284" /energy="-5.9" /TU="NA" /idTUdmin="U1070" /TUdmin=9 /isTUend="TRUE" /label="downshifts" promotor_-35 1307895..1307902 /Source="Nicolas_upshift_promotors" /id="U1072" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=2735 /SigmaFactorBS="tccgtaattgtgatgtaagcgcatttattacttttttGAGTT GACatagcttgtttttTTCTGTAATCTCAGTGTGTCaattcaattaggaacttcgtta g" /listShort="S473, S474, mgtE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1307916..1307935 /Source="Nicolas_upshift_promotors" /id="U1072" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=2735 /SigmaFactorBS="tccgtaattgtgatgtaagcgcatttattacttttttGAGTT GACatagcttgtttttTTCTGTAATCTCAGTGTGTCaattcaattaggaacttcgtta g" /listShort="S473, S474, mgtE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1307918..1308237 /Source="Nicolas_S_feature" /locus_tag="new_1395590_1395909" /HighExp="LBGstat, LBGtran, M40t45, MG 25, Mt0, Salt, MG 45, LPhT, BMM, MG t5" /AntisenseName="ykzO" /AntisenseCor="-0.16301119751811899" /AntisenseRegPval="-2.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S473" upshifts 1307918 /Source="Nicolas_upshifts" /id="U1072" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=2735 /SigmaFactorBS="tccgtaattgtgatgtaagcgcatttattacttttttGAGTT GACatagcttgtttttTTCTGTAATCTCAGTGTGTCaattcaattaggaacttcgtta g" /listShort="S473, S474, mgtE" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 1307950..1308103 /gene="swmG" /locus_tag="BSU_misc_RNA_68" /product="magnesium riboswitch" /experiment="publication(s) with functional evidences, PMID:15096624, 17803910, 21315082, 28455443" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15096624, 17803910, 21315082, 28455443; Product type n: RNA" /function="16.12: Sense" /function="16.3: Control" /label="swmG RNA" gene 1307950..1308103 /gene="swmG" /locus_tag="BSU_misc_RNA_68" /label="swmG gene" promotor_-35 1308215..1308224 /Source="Nicolas_upshift_promotors" /id="U1073" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=1632 /SigmaFactorBS="ccaatcaaaggaggtgcggagtatggattctccccaTTCGAG TCAAtctgaagaagtaCCCATATACTATGACAGCAAgacaattgattacacgatgagg a" /listShort="S474, mgtE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1308237..1308256 /Source="Nicolas_upshift_promotors" /id="U1073" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=1632 /SigmaFactorBS="ccaatcaaaggaggtgcggagtatggattctccccaTTCGAG TCAAtctgaagaagtaCCCATATACTATGACAGCAAgacaattgattacacgatgagg a" /listShort="S474, mgtE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1308239..1308340 /Source="Nicolas_S_feature" /locus_tag="new_1395911_1396012" /HighExp="LBGstat, LBGtran, M40t45, Mt0, LPhT, Paraq, MG t5, MG 25, MG 60, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99773400000000001" /TUshortSig="SigK, SigA" /TUshortPSig="0.876, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S474" upshifts 1308239 /Source="Nicolas_upshifts" /id="U1073" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.876123876123876" /psig="0.876123876123876" /xcortree=1632 /SigmaFactorBS="ccaatcaaaggaggtgcggagtatggattctccccaTTCGAG TCAAtctgaagaagtaCCCATATACTATGACAGCAAgacaattgattacacgatgagg a" /listShort="S474, mgtE" /GFF_Attribute="listLong" /label="upshifts" CDS 1308341..1309696 /gene="mgtE" /locus_tag="BSU_13300" /old_locus_tag="BSU13300" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15096624, 22970223, 24415722, 24968120, 25182490" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15096624, 22970223, 24415722, 24968120, 25182490; Product type t : transporter" /codon_start=1 /transl_table=11 /product="magnesium transporter" /protein_id="NP_389213.1" /db_xref="EnsemblGenomes-Gn:BSU13300" /db_xref="EnsemblGenomes-Tr:CAB13187" /db_xref="GOA:O34442" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR006667" /db_xref="InterPro:IPR006668" /db_xref="InterPro:IPR006669" /db_xref="InterPro:IPR036739" /db_xref="SubtiList:BG13256" /db_xref="UniProtKB/Swiss-Prot:O34442" /translation="MVQNMTYDELILRIIILLRDGKIRDFRSVIDELQPYDMAFIFKE MPEKHRARYLSYLTVDDITDMIGELEREFQLVVLNKVGKTKATLAMNKMDNDDLAQLL EEMDEELKEQLLSSMEASESKAVQLLMNYPADSAGRMMTNRYVWIPQHYTVKDAVVKL KSFAEIAESINYLYVINESKQLVGVLSYRDLILGEPEEKVQDLMFTRVISADALQDQE EVARLIERYDFLAIPVVEENNVLVGIVTVDDIIDVVIREADEDYEKFAASGKDITFDT KAYVAAYRRLPWLILLLFIGLISGSIISYFEDALKQVVALAFFMPMVSGMTGNTGTQS LAVVIRGLSKEEMNKKTIVRLIFREFRTSIFIGAVCSVLIAIVSIIWQGNALLGFVVA SSLFLTLIIGTMSGTIIPIILHKLKVDPAIASGPLITTLNDILSLLIYFGIATAFIHS L*" /label="mgtE CDS" gene 1308341..1309696 /gene="mgtE" /locus_tag="BSU_13300" /old_locus_tag="BSU13300" /label="mgtE gene" downshifts 1309687 /Source="Nicolas_upshifts" /id="D729" /incds=0 /nref=160 /ntot=239 /MaxReadThrough="1.02063" /MaxDrop="7.38933" /score="-4.14569718" /energy="-8.9" /TU="NA" /idTUdmin="U1072" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS complement(1309739..1310071) /gene="tnrA" /locus_tag="BSU_13310" /old_locus_tag="BSU13310" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10231480, 12823818, 15916606, 16547045, 17085574, 17183219, 21435182, 23535029, 26635369" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10231480, 12823818, 15916606, 16547045, 17085574, 17183219, 21435182, 23535029, 26635369; Product type r: regulator" /codon_start=1 /transl_table=11 /product="nitrogen sensing transcriptional regulator" /protein_id="NP_389214.1" /db_xref="EnsemblGenomes-Gn:BSU13310" /db_xref="EnsemblGenomes-Tr:CAB13188" /db_xref="GOA:Q45666" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="PDB:4S0R" /db_xref="SubtiList:BG11805" /db_xref="UniProtKB/Swiss-Prot:Q45666" /translation="MTTEDHSYKDKKVISIGIVSELTGLSVRQIRYYEERKLIYPQRS SRGTRKYSFADVERLMDIANKREDGVQTAEILKDMRKKEQMLKNDPQVRKKMLEGQLN AHFRYKNR*" /label="tnrA CDS" gene complement(1309739..1310071) /gene="tnrA" /locus_tag="BSU_13310" /old_locus_tag="BSU13310" /label="tnrA gene" promotor_-10 complement(1310087..1310106) /Source="Nicolas_upshift_promotors" /id="U1074" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig="0.99100899100899" /xcortree=1709 /SigmaFactorBS="tttgatgttagaaaatatgacaagcgtcagGTTTTTtctctt tgttttttaTATACTATTATCAAAAGACAtccaggggtggaaaaatgaccacagaaga t" /listShort="tnrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1310097) /Source="Nicolas_upshifts" /id="U1074" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig="0.99100899100899" /xcortree=1709 /SigmaFactorBS="tttgatgttagaaaatatgacaagcgtcagGTTTTTtctctt tgttttttaTATACTATTATCAAAAGACAtccaggggtggaaaaatgaccacagaaga t" /listShort="tnrA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1310099..1310487) /Source="Nicolas_S_feature" /locus_tag="new_1397771_1398159_c" /HighExp="M9-stat, BC, LoTm, T1.30H, T0.30H, T2.0H, S8, C30, T4.0H, T2.30H" /AntisenseName="ykzB" /AntisenseCor="-3.3870578787867499E-2" /AntisenseRegPval="-0.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.92" /TUlongSig="NA" /TUlongPSig="NA" /label="S475" promotor_-35 complement(1310122..1310127) /Source="Nicolas_upshift_promotors" /id="U1074" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig="0.99100899100899" /xcortree=1709 /SigmaFactorBS="tttgatgttagaaaatatgacaagcgtcagGTTTTTtctctt tgttttttaTATACTATTATCAAAAGACAtccaggggtggaaaaatgaccacagaaga t" /listShort="tnrA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_no_box 1310159..1310259 /Source="Nicolas_upshift_promotors" /id="U1075" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.375624375624376" /psig="0.295704295704296" /xcortree=315 /SigmaFactorBS="agaagatttttgaaaaaatacggaagaaaaattaacaagaat aatgcgtaacacccaagcgcgttttatcctttatgtaacgaatcaaacgaggaggaag g" /listShort="ykzB, ykoL" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 1310219 /Source="Nicolas_upshifts" /id="U1075" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.375624375624376" /psig="0.295704295704296" /xcortree=315 /SigmaFactorBS="agaagatttttgaaaaaatacggaagaaaaattaacaagaat aatgcgtaacacccaagcgcgttttatcctttatgtaacgaatcaaacgaggaggaag g" /listShort="ykzB, ykoL" /GFF_Attribute="listLong" /label="upshifts" CDS 1310266..1310421 /gene="ykzB" /locus_tag="BSU_13320" /old_locus_tag="BSU13320" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 10671441" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389215.1" /db_xref="EnsemblGenomes-Gn:BSU13320" /db_xref="EnsemblGenomes-Tr:CAB13189" /db_xref="SubtiList:BG13330" /db_xref="UniProtKB/Swiss-Prot:O34923" /translation="MEEEKAVSLAKEIIELDIKRDEMLETFMQLAGEQAFQLLRSVQN GQYRKSS*" /label="ykzB CDS" gene 1310266..1310421 /gene="ykzB" /locus_tag="BSU_13320" /old_locus_tag="BSU13320" /label="ykzB gene" promotor_-35 1310430..1310437 /Source="Nicolas_upshift_promotors" /id="U1076" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.985014985014985" /psig="0.006993006993007" /xcortree=10 /SigmaFactorBS="caataccgaaaatcttcgtaaacataaatTCTTTACAttaga tTCATACCACGTTCATTTAaaaagagtatcttttgtataggatacctcaaaatgaagg a" /listShort="ykoL, S476, ykoM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1310444..1310461 /Source="Nicolas_upshift_promotors" /id="U1076" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.985014985014985" /psig="0.006993006993007" /xcortree=10 /SigmaFactorBS="caataccgaaaatcttcgtaaacataaatTCTTTACAttaga tTCATACCACGTTCATTTAaaaagagtatcttttgtataggatacctcaaaatgaagg a" /listShort="ykoL, S476, ykoM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1310461 /Source="Nicolas_upshifts" /id="U1076" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.985014985014985" /psig="0.006993006993007" /xcortree=10 /SigmaFactorBS="caataccgaaaatcttcgtaaacataaatTCTTTACAttaga tTCATACCACGTTCATTTAaaaagagtatcttttgtataggatacctcaaaatgaagg a" /listShort="ykoL, S476, ykoM" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1310472..1310491) /Source="Nicolas_upshift_promotors" /id="U1077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.394605394605395" /psig="0.92007992007992" /xcortree=3030 /SigmaFactorBS="tcgttctttttctaaagcggatttcaataaattactCATAGC GtcctccttcatttTGAGGTATCCTATACAAAAGatactctttttaaatgaacgtggt a" /listShort="S475, tnrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1310487) /Source="Nicolas_upshifts" /id="U1077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.394605394605395" /psig="0.92007992007992" /xcortree=3030 /SigmaFactorBS="tcgttctttttctaaagcggatttcaataaattactCATAGC GtcctccttcatttTGAGGTATCCTATACAAAAGatactctttttaaatgaacgtggt a" /listShort="S475, tnrA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1310505..1310511) /Source="Nicolas_upshift_promotors" /id="U1077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.394605394605395" /psig="0.92007992007992" /xcortree=3030 /SigmaFactorBS="tcgttctttttctaaagcggatttcaataaattactCATAGC GtcctccttcatttTGAGGTATCCTATACAAAAGatactctttttaaatgaacgtggt a" /listShort="S475, tnrA" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1310509..1310691 /gene="ykoL" /locus_tag="BSU_13330" /old_locus_tag="BSU13330" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 10671441" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389216.1" /db_xref="EnsemblGenomes-Gn:BSU13330" /db_xref="EnsemblGenomes-Tr:CAB13190" /db_xref="SubtiList:BG13257" /db_xref="UniProtKB/Swiss-Prot:O34763" /translation="MSNLLKSALEKERRHYSEKLYQIGVYNKEVMNKMTISELRKEYA YFFRSITNHKNYPYTR*" /label="ykoL CDS" gene 1310509..1310691 /gene="ykoL" /locus_tag="BSU_13330" /old_locus_tag="BSU13330" /label="ykoL gene" downshifts 1310659 /Source="Nicolas_upshifts" /id="D730" /incds=0 /nref=2 /ntot=8 /MaxReadThrough="3.83398" /MaxDrop="4.6651" /score="19.6832496" /energy="-11.2" /TU="U1076" /idTUdmin="U1075" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1310716..1310724 /Source="Nicolas_upshift_promotors" /id="U1078" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=361 /SigmaFactorBS="atacaagataatgtataaggatttttttgcttttaGAAGGAA TTtctcgaattaTAGCGAATACGTATAGTAAgggactgaactcttattatatgtaagg g" /listShort="S476, ykoM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1310735..1310753 /Source="Nicolas_upshift_promotors" /id="U1078" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=361 /SigmaFactorBS="atacaagataatgtataaggatttttttgcttttaGAAGGAA TTtctcgaattaTAGCGAATACGTATAGTAAgggactgaactcttattatatgtaagg g" /listShort="S476, ykoM" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1310741..1310823 /Source="Nicolas_S_feature" /locus_tag="new_1398413_1398495" /HighExp="T3.0H, M9-stat, T1.30H, T2.30H, Lbstat, T3.30H, Lbtran, S2, T4.0H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH, Sig-" /TUshortPSig="0.996, 0.00699" /TUlongSig="NA" /TUlongPSig="NA" /label="S476" upshifts 1310741 /Source="Nicolas_upshifts" /id="U1078" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=361 /SigmaFactorBS="atacaagataatgtataaggatttttttgcttttaGAAGGAA TTtctcgaattaTAGCGAATACGTATAGTAAgggactgaactcttattatatgtaagg g" /listShort="S476, ykoM" /GFF_Attribute="listLong" /label="upshifts" CDS 1310824..1311288 /gene="ykoM" /locus_tag="BSU_13340" /old_locus_tag="BSU13340" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MarR family)" /protein_id="NP_389217.1" /db_xref="EnsemblGenomes-Gn:BSU13340" /db_xref="EnsemblGenomes-Tr:CAB13191" /db_xref="GOA:O34949" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13258" /db_xref="UniProtKB/Swiss-Prot:O34949" /translation="MMRLSFNEEEVERAMNLYRVFARAFKSVSEHSIRDSKEHGFNPT EFAVLELLYTRGPQKLQQIGSRLLLVSGNVTYVIDKLERNGFLVREQDPKDKRSVYAH LTDKGNEYLDKIYPIHALRIARAFSGLSPDEQDQLIVLLKKAGIHSQHLLFR*" /label="ykoM CDS" gene 1310824..1311288 /gene="ykoM" /locus_tag="BSU_13340" /old_locus_tag="BSU13340" /label="ykoM gene" downshifts 1311273 /Source="Nicolas_upshifts" /id="D731" /incds=0 /nref=70 /ntot=210 /MaxReadThrough="2.86787" /MaxDrop="5.38705" /score="24.8730632" /energy="-9.8" /TU="U1078" /idTUdmin="U1078" /TUdmin="-112" /isTUend="FALSE" /label="downshifts" CDS complement(1311303..1312424) /gene="ykoN" /locus_tag="BSU_13350" /old_locus_tag="BSU13350" /EC_number="2.4.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_389218.2" /db_xref="EnsemblGenomes-Gn:BSU13350" /db_xref="EnsemblGenomes-Tr:CAB13192" /db_xref="GOA:C0SPB9" /db_xref="InterPro:IPR009695" /db_xref="SubtiList:BG13259" /db_xref="UniProtKB/Swiss-Prot:C0SPB9" /translation="MKNILIFPFLSISTGHHHVADALQAELESQGLAAEKIDIFSHSY RRLEKLSSVAYLKWIQYFPKTYSGIYRLLACGEFQHDKRYFMYEWLFTQQMRHILQEK QPDIAFCTHALPSYLLNRLKPEYPNLTVVNVYTDFFVNQLWGRKNIDYHFVPSTEVKK QLISEGIDQNNIYLTGIPVHQNFEMESADTLQHHPPYTIIITGGSMGVGGILKWVQEL SPGGKILYKILCGRNEKLYSYVKSLHHPLIEAIPYLHSKAEMNRLYEQATGIMTKPGG VTISECLQKRLPVFIYHALPGQEEMNLNLLHERKLVTDMRNWDMQKAEEYIAAFFQSN EQMKEYKKHVNGYLGEMSDRKIKDVLKRIIWKQKNTLLK*" /label="ykoN CDS" gene complement(1311303..1312424) /gene="ykoN" /locus_tag="BSU_13350" /old_locus_tag="BSU13350" /label="ykoN gene" promotor_-35 1311712..1311720 /Source="Nicolas_upshift_promotors" /id="U1079" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=1311 /SigmaFactorBS="cctcaatcaaggggtggtgtaaacttttgacatagGAGTAGA GCttttcgtttctgcCGCATAATATTTTGTATAAGatctttccgcctggcgacagttc c" /listShort="S477, ykoP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1311734..1311753 /Source="Nicolas_upshift_promotors" /id="U1079" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=1311 /SigmaFactorBS="cctcaatcaaggggtggtgtaaacttttgacatagGAGTAGA GCttttcgtttctgcCGCATAATATTTTGTATAAGatctttccgcctggcgacagttc c" /listShort="S477, ykoP" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1311737..1312515 /Source="Nicolas_S_feature" /locus_tag="new_1399409_1400187" /HighExp="S6, S8, S7, S5, BT, B36, S4, S3, Pyr, G/S" /AntisenseName="ykoN" /AntisenseCor="0.84084970563549499" /AntisenseRegPval="-72.400000000000006" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.979" /TUlongSig="NA" /TUlongPSig="NA" /label="S477" upshifts 1311737 /Source="Nicolas_upshifts" /id="U1079" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=1311 /SigmaFactorBS="cctcaatcaaggggtggtgtaaacttttgacatagGAGTAGA GCttttcgtttctgcCGCATAATATTTTGTATAAGatctttccgcctggcgacagttc c" /listShort="S477, ykoP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1312453..1312464) /Source="Nicolas_upshift_promotors" /id="U1080" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=819 /SigmaFactorBS="aaggaaacaagttttcatcttttcaccttccttatgatcaaa aacaccCTTATATtttgtgaacgttctCCTCAAAATATAgttgccatatttttttagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1312473) /Source="Nicolas_upshifts" /id="U1080" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=819 /SigmaFactorBS="aaggaaacaagttttcatcttttcaccttccttatgatcaaa aacaccCTTATATtttgtgaacgttctCCTCAAAATATAgttgccatatttttttagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1312479..1312485) /Source="Nicolas_upshift_promotors" /id="U1080" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=819 /SigmaFactorBS="aaggaaacaagttttcatcttttcaccttccttatgatcaaa aacaccCTTATATtttgtgaacgttctCCTCAAAATATAgttgccatatttttttagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1312516..1313067 /gene="ykoP" /locus_tag="BSU_13360" /old_locus_tag="BSU13360" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389219.2" /db_xref="EnsemblGenomes-Gn:BSU13360" /db_xref="EnsemblGenomes-Tr:CAB13193" /db_xref="SubtiList:BG13260" /db_xref="UniProtKB/Swiss-Prot:O34495" /translation="MKTCFLSIWRVVDPIYFFFSRLSLIDNDQKSVFRVRLTKYKGHH VVLSDGTHIRKNDVLVKIHLHNIKLIRELQSIESAVRKGIIIYQKVYQSMPLLLDYIN NHKKSEKIKGIIGITMLDKGVERLGFDVITPVNPFYRCFKKVSHVPILYLTSKPVSLR HLPNSSYLFISKEKLQKTYQKKD*" /label="ykoP CDS" gene 1312516..1313067 /gene="ykoP" /locus_tag="BSU_13360" /old_locus_tag="BSU13360" /label="ykoP gene" downshifts 1313035 /Source="Nicolas_upshifts" /id="D732" /incds=0 /nref=4 /ntot=25 /MaxReadThrough="3.31887" /MaxDrop="3.7149" /score="-2.92393792" /energy="-7" /TU="U1079" /idTUdmin="U1079" /TUdmin="-242" /isTUend="FALSE" /label="downshifts" CDS complement(1313095..1313907) /gene="ykoQ" /locus_tag="BSU_13370" /old_locus_tag="BSU13370" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metallophosphoesterase" /protein_id="NP_389220.1" /db_xref="EnsemblGenomes-Gn:BSU13370" /db_xref="EnsemblGenomes-Tr:CAB13194" /db_xref="GOA:O35040" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG13261" /db_xref="UniProtKB/Swiss-Prot:O35040" /translation="MFTILLSLAILVFVPFLYKANRNTKDVKVNTISIDQKDGLPARK KLNILHLSDLHLENISVSPEELYHLTKDQPVDIIALTGDFLDRKRNIPKLAGYLNALQ KLKPAYGMYAVFGNHDYVLKEEDFQRLKRVLEENGCITLQNEHVRIETAAGPVNIIGI DDYSTNRSNITGSYQSLENGYHLVLTHDPNIILDMKDVHYDYLLSGHFHGGQIHWPKP YHLVKMGKLVRMNMIKGLHYHHDKPFYISEGLGQTGVNIRVGSRPEVTFHQI*" /label="ykoQ CDS" gene complement(1313095..1313907) /gene="ykoQ" /locus_tag="BSU_13370" /old_locus_tag="BSU13370" /label="ykoQ gene" promotor_-10 complement(1313867..1313886) /Source="Nicolas_upshift_promotors" /id="U1081" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.485514485514486" /psig="0.997002997002997" /xcortree=2484 /SigmaFactorBS="acttactatactgatagaagggaggggatatattttGTTTAC aatcttactttcaTTGGCCATACTCGTATTTGTgccatttctatataaagcgaaccgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1313881) /Source="Nicolas_upshifts" /id="U1081" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.485514485514486" /psig="0.997002997002997" /xcortree=2484 /SigmaFactorBS="acttactatactgatagaagggaggggatatattttGTTTAC aatcttactttcaTTGGCCATACTCGTATTTGTgccatttctatataaagcgaaccgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1313900..1313905) /Source="Nicolas_upshift_promotors" /id="U1081" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.485514485514486" /psig="0.997002997002997" /xcortree=2484 /SigmaFactorBS="acttactatactgatagaagggaggggatatattttGTTTAC aatcttactttcaTTGGCCATACTCGTATTTGTgccatttctatataaagcgaaccgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1314008..1314014 /Source="Nicolas_upshift_promotors" /id="U1082" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=939 /SigmaFactorBS="aattaatgggtagagacaggttgaaaaacggattgtcatatg aTGAATGAtttggaagggaaaAGGGATAATAAAttttgacacatgaggcagaacatgc c" /listShort="S478, ykoS, ykoT" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1314025..1314099 /Source="Nicolas_S_feature" /locus_tag="new_1401697_1401771" /HighExp="S5, S6, S7, S4, S8, T5.0H, ferm, nit, S3, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S478" upshifts 1314025 /Source="Nicolas_upshifts" /id="U1082" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=939 /SigmaFactorBS="aattaatgggtagagacaggttgaaaaacggattgtcatatg aTGAATGAtttggaagggaaaAGGGATAATAAAttttgacacatgaggcagaacatgc c" /listShort="S478, ykoS, ykoT" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1314028..1314039 /Source="Nicolas_upshift_promotors" /id="U1082" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=939 /SigmaFactorBS="aattaatgggtagagacaggttgaaaaacggattgtcatatg aTGAATGAtttggaagggaaaAGGGATAATAAAttttgacacatgaggcagaacatgc c" /listShort="S478, ykoS, ykoT" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1314100..1315794 /gene="ykoS" /locus_tag="BSU_13380" /old_locus_tag="BSU13380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_389221.1" /db_xref="EnsemblGenomes-Gn:BSU13380" /db_xref="EnsemblGenomes-Tr:CAB13195" /db_xref="GOA:O34830" /db_xref="SubtiList:BG13262" /db_xref="UniProtKB/Swiss-Prot:O34830" /translation="MLRLMRQQKKETYYLWIALFLLLLYVSPLFILKEDAHIRVHDNL DSNIAWYKVLADSGEIVGKVDAAIPQIINGLPRDAFGTEWSGIVWLHAFFSSMTAYAI SQTVTRVVAFFGMYVLLKKHIIPEPKAAFIRIGVSLAFALTPFWPSGMLSTLGYPLAL WAFLNIRKGDISWREWLTLGLLPLYSSFVLGFFFFLAGMACFWLYDAITKRRWNLMFL GSIAFMTSIYLFVEYRLVYSMLFEHAPMHRIEFISSRHDVWHSLRLSIKNFVYGHNHV MTVHTVVILPILMVVFAALLFKRNRTKPENVYLFLCVLNYGLSLWYAFWFNKIWAVPK QKFAFLAEFNFARFHFLRPLVIYVSFALALYLIWRMGKGWKWLVYAAVAAQLMVLAPF NEEYTYGVHYNAPTFREFYASEQFKEIKEYIGRPQDSYRVASIGLHPSIAQYNGFYTL DTYNNLYPLSYKYEFRKIIEKELEKNSRLKQYFDEWGSRCYLFVDELGKRYDFKKNSK KTINNLQLNTDVFKKMGGRYIFSSVPIMNAEQNHLALVKTFDHKDSAWRIYLYETR*" /label="ykoS CDS" gene 1314100..1315794 /gene="ykoS" /locus_tag="BSU_13380" /old_locus_tag="BSU13380" /label="ykoS gene" CDS 1315807..1316820 /gene="ykoT" /locus_tag="BSU_13390" /old_locus_tag="BSU13390" /EC_number="2.-.-.-" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_389222.1" /db_xref="EnsemblGenomes-Gn:BSU13390" /db_xref="EnsemblGenomes-Tr:CAB13196" /db_xref="GOA:O34755" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG13263" /db_xref="UniProtKB/Swiss-Prot:O34755" /translation="MKQSQPVLTIVVPCFNEEEVFQETSHQLTEVVDDLIEEKLIAED SKILFVDDGSKDRTWALIAMESIRNKKVTGLKLACNVGHQKALLAGLHKAKNRSDCVI SIDADLQDDISVIRDFMLKYHEGCEIVYGVRRSRKTDTFFKRTTALGFYRLMNKLGIK LIYNHADFRLMNKRSLEELERYPEANLFLRGIVPMIGFKSAEVLYDRKERFAGKTKYP LKKMLSFAFNGITSFSVAPIRFFTLLGFVLFFLSAVAGIGAFIQKLLGHTNAGWASLI ISIWFLGGLQLMGIGIIGEYIGTIFSEVKRRPKYAIDIDLYNEQLSPLQRQEKERLEK KYS*" /label="ykoT CDS" gene 1315807..1316820 /gene="ykoT" /locus_tag="BSU_13390" /old_locus_tag="BSU13390" /label="ykoT gene" downshifts 1316805 /Source="Nicolas_upshifts" /id="D733" /incds=0 /nref=13 /ntot=35 /MaxReadThrough="0.53349" /MaxDrop="4.80671" /score="19.4012674" /energy="-13.7" /TU="NA" /idTUdmin="U1082" /TUdmin=8 /isTUend="TRUE" /label="downshifts" CDS complement(1316846..1318681) /gene="ligD" /locus_tag="BSU_13400" /old_locus_tag="BSU13400" /EC_number="6.5.1.1" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12215643, 16497325, 17293412, 23691176, 25355514, 26826709" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12215643, 16497325, 17293412, 23691176, 25355514, 26826709; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent DNA ligase subunit; 5'-2-deoxyribose-5-phosphate (dRP) lyase" /protein_id="NP_389223.1" /db_xref="EnsemblGenomes-Gn:BSU13400" /db_xref="EnsemblGenomes-Tr:CAB13197" /db_xref="GOA:O34398" /db_xref="InterPro:IPR012310" /db_xref="InterPro:IPR014143" /db_xref="InterPro:IPR014145" /db_xref="InterPro:IPR014146" /db_xref="InterPro:IPR033652" /db_xref="SubtiList:BG13264" /db_xref="UniProtKB/Swiss-Prot:O34398" /translation="MAFTMQPVLTSSPPIGAEWRYEVKYDGYRCILRIHSSGVTLTSR NGVELSSTFPEITQFAKTAFQHLEKELPLTLDGEIVCLVNPCRADFEHLQVRGRLKRP DKIQESANARPCCFLAFDLLERSGEDVTLLSYLDRKKSLRELISAAKLPASPDPYAKE TIQSIPCYDHFDQLWEMVIKYDGEGIVAKKTNSKWLEKKRSSDWLKYKNFKQAYVCIT GFNPNNGFLTVSVLKNGIMTPIASVSHGMRDEEKSAIREIMEQHGHQTPSGEFTLEPS ICAAVQYLTILQGTLREVSFIGFEFQMDWTECTYAQVIRHSKPVHPKLQFTSLDKIIF EKNKKTKEDFIQYMIEVSDYLLPFLKNRAVTVIRYPHGSRSESFFQKNKPDYAPDFVQ SFYDGSHEHIVCEDMSTLLWLCNQLALEFHVPFQTIKSRRPAEIVIDLDPPSRDDFLM AVQAANELKRLLDSFGITSYPKLSGNKGIQLYIPLSPEAFTYEETRQFTQLIAEYCTN AFPELFTTERLIKNRHCKLYLDYLQHAEGKTIICPYSTRGNELGTVAAPLYWHEVQSS LTPALFTIDTVIDRIKKQGCPFFDFYRNPQDEPLSAILHQLKKKS*" /label="ligD CDS" gene complement(1316846..1318681) /gene="ligD" /locus_tag="BSU_13400" /old_locus_tag="BSU13400" /label="ligD gene" downshifts complement(1316895) /Source="Nicolas_upshifts" /id="D734" /incds=0 /nref=10 /ntot=54 /MaxReadThrough="0.67916" /MaxDrop="5.08051" /score="-8.48510187" /energy="-13.7" /TU="NA" /idTUdmin="U1083" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1318685..1319620) /gene="ligV" /locus_tag="BSU_13410" /old_locus_tag="BSU13410" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11095673, 12215643, 16497325, 16780573, 23691176, 25355514" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11095673, 12215643, 16497325, 16780573, 23691176, 25355514; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent DNA ligase subunit Ku; AP/deoxyribose 5'-phosphate (5'-dRP)-lyase" /protein_id="NP_389224.1" /db_xref="EnsemblGenomes-Gn:BSU13410" /db_xref="EnsemblGenomes-Tr:CAB13198" /db_xref="GOA:O34859" /db_xref="InterPro:IPR006164" /db_xref="InterPro:IPR009187" /db_xref="InterPro:IPR016194" /db_xref="SubtiList:BG13265" /db_xref="UniProtKB/Swiss-Prot:O34859" /translation="MNRTPSLHTKEKKGFIDMHTMWKGSISFGLVNIPIKLYAATEDK DIKLRSLHKEDHAPIKYEKVCTNCEKTLSPDEIVKGYEYVKGKYVVLTDEDLKSLKQE HEEKAVEIVDFVQLQEIDPIYFNRSYFVGPGDNGTKAYTLLREALRSTGKIGIANMTI RSKQQLAILRVYENCIVMESIHYPDEVRSAAQVPGVPDQSNVNDKELQTAITLIDELT AKFEPEKYEDTYRQALLQRVNDKLENKETAVTPDKAPPREDVIDLVSALQASIDRTRR PNRETPAAAPAQAAEPKGAGDKKQKTTRKKASGTS*" /label="ligV CDS" gene complement(1318685..1319620) /gene="ligV" /locus_tag="BSU_13410" /old_locus_tag="BSU13410" /label="ligV gene" promotor_-10 complement(1319591..1319602) /Source="Nicolas_upshift_promotors" /id="U1083" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=856 /SigmaFactorBS="aataacagcgccggctttttttcacccataagttactaCACA TGAatcgtactccttctCTTCACACTAAAgaaaaaaaggggtttatcgatatgcatac a" /listShort="ykoV, ykoU" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1319601) /Source="Nicolas_upshifts" /id="U1083" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=856 /SigmaFactorBS="aataacagcgccggctttttttcacccataagttactaCACA TGAatcgtactccttctCTTCACACTAAAgaaaaaaaggggtttatcgatatgcatac a" /listShort="ykoV, ykoU" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1319617..1319623) /Source="Nicolas_upshift_promotors" /id="U1083" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=856 /SigmaFactorBS="aataacagcgccggctttttttcacccataagttactaCACA TGAatcgtactccttctCTTCACACTAAAgaaaaaaaggggtttatcgatatgcatac a" /listShort="ykoV, ykoU" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1319657..1322059) /gene="dgcW" /locus_tag="BSU_13420" /old_locus_tag="BSU13420" /EC_number="2.7.7.65" /function="16.3: Control" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11728710, 17010156, 23893111, 28536559" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11728710, 17010156, 23893111, 28536559; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="diguanylate cyclase" /protein_id="YP_054577.2" /db_xref="EnsemblGenomes-Gn:BSU13420" /db_xref="EnsemblGenomes-Tr:CAB13199" /db_xref="GOA:O34311" /db_xref="InterPro:IPR000160" /db_xref="InterPro:IPR001633" /db_xref="InterPro:IPR005330" /db_xref="InterPro:IPR029787" /db_xref="InterPro:IPR035919" /db_xref="InterPro:IPR035965" /db_xref="SubtiList:BG13266" /db_xref="UniProtKB/Swiss-Prot:O34311" /translation="MEIHVTYNTTLICLSILIACTASYISLELSRKVTINTGLKSKIW LIGGSLIMGFGIWSMHFVGMMAVHMEMPMEYEFMPLMAAIGASVSGSFVSLYFVSRHI LTYYRLLTGSVVLGASIASMHYIGMSAISRVMIIYEPILFTVSIIIAIAASFVSLKIF FDLAVKKHSEHLIFYKGVSSIVMGIGISGMHYTGMLAATFHKDMAPPGSHMEVQTFHW SIFVTLIIFCIQTLLLFSSHADRKFIKQSERIKDNEQRFQSLIVHNIDAIFILSLEGD IISSNHAGEEMISKFGFSMHDWRNYTSLKVKRLFEQVKKDKQAMNSDSDLITEKGQFH LNITLIPVEVNQELDSIYVICKDMTKQYKAEKEIHRMAHYDSLTDLPNRRHAISHLTK VLNREHSLHYNTVVFFLDLNRFKVINDALGHNVGDQLLQFAAKRLSSVVPDNGFIARL GGDEFIIILTDANTGTGEADVLARKIIQKFKKPFKIQDHTLVTSVSIGIAISPKDGTD GLELMKKADMAMYAAKERNKSKYRYYSFSIGNKETVKLNQEMVLREAIENDRFVLHYQ PQFSVKKQKMTGAEALIRLVTPDGQLRPPGEFIGVAEETGLIIDIGKWIIDEACKQAR IWHDKGYDLSVAINISARQFQSKDLIPLIKDTLNKYQLPPQLLEVEVTESMTMDNLNH SKKVLSSLTELGIRISIDDFGTGHSSLSYLKDFPIHRLKIDKSFIDDIQTHPKSEQIT GAIIAMGHQLSLQVIAEGVENAAQKQLLFEKGCDHLQGFFFSRPIPPEQFEQFIIEQP SQ*" /label="dgcW CDS" gene complement(1319657..1322059) /gene="dgcW" /locus_tag="BSU_13420" /old_locus_tag="BSU13420" /label="dgcW gene" downshifts complement(1319689) /Source="Nicolas_upshifts" /id="D735" /incds=0 /nref=13 /ntot=101 /MaxReadThrough="1.93589" /MaxDrop="3.26543" /score="6.55794882" /energy="-9" /TU="NA" /idTUdmin="U1084" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1321907..1322109) /Source="Nicolas_S_feature" /locus_tag="new_1409579_1409781_c" /HighExp="Cold, GM 25, GM 10, GM 45, GM 15, GM-0.2, GM-0.1, GM 5, GM 90, Glu" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S479" promotor_-10 complement(1322098..1322116) /Source="Nicolas_upshift_promotors" /id="U1084" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2819 /SigmaFactorBS="agatctccctcgtatttctatcgttttgaaggCTGAAACTct gcggttaagcaGCCGATAATAAAGAGAGTCaacaagactggaacacacgatacggggg g" /listShort="S479, ykoW" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1322109) /Source="Nicolas_upshifts" /id="U1084" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2819 /SigmaFactorBS="agatctccctcgtatttctatcgttttgaaggCTGAAACTct gcggttaagcaGCCGATAATAAAGAGAGTCaacaagactggaacacacgatacggggg g" /listShort="S479, ykoW" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1322130..1322137) /Source="Nicolas_upshift_promotors" /id="U1084" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2819 /SigmaFactorBS="agatctccctcgtatttctatcgttttgaaggCTGAAACTct gcggttaagcaGCCGATAATAAAGAGAGTCaacaagactggaacacacgatacggggg g" /listShort="S479, ykoW" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1322176..1322183 /Source="Nicolas_upshift_promotors" /id="U1085" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.432567432567433" /psig="0.999000999001" /xcortree=1761 /SigmaFactorBS="atagaaatacgagggagatctatttttAGTTCAACtgaccgt gaaaaaTGTGTTAAAATCATCTTGATgttttccgaaaagagaaaaatgtatgatacat a" /listShort="ykoX, ykoY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1322197..1322216 /Source="Nicolas_upshift_promotors" /id="U1085" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.432567432567433" /psig="0.999000999001" /xcortree=1761 /SigmaFactorBS="atagaaatacgagggagatctatttttAGTTCAACtgaccgt gaaaaaTGTGTTAAAATCATCTTGATgttttccgaaaagagaaaaatgtatgatacat a" /listShort="ykoX, ykoY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1322209 /Source="Nicolas_upshifts" /id="U1085" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.432567432567433" /psig="0.999000999001" /xcortree=1761 /SigmaFactorBS="atagaaatacgagggagatctatttttAGTTCAACtgaccgt gaaaaaTGTGTTAAAATCATCTTGATgttttccgaaaagagaaaaatgtatgatacat a" /listShort="ykoX, ykoY" /GFF_Attribute="listLong" /label="upshifts" CDS 1322240..1322905 /gene="ykoX" /locus_tag="BSU_13430" /old_locus_tag="BSU13430" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 23687963; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_389226.1" /db_xref="EnsemblGenomes-Gn:BSU13430" /db_xref="EnsemblGenomes-Tr:CAB13200" /db_xref="GOA:O34908" /db_xref="InterPro:IPR032816" /db_xref="SubtiList:BG13267" /db_xref="UniProtKB/Swiss-Prot:O34908" /translation="MIHKHETRELVAIEELVMSWIEAFKSLSYFGIFLALSIEFIPAE VVLPLAGYWVSKGDMTLAGVVLAGSLGGVAGPLTLYWIGRYGGRPFLERFGKYLFIKP EALDKSDNFFKKHGGFVAFSGRFLPGIRTLISIPCGIAKMNVWVFSLYTFIAMLPITF VYVYLGVKLGENWKAVGSILDQYMLPIGIAILALFLLYLLMKKRKKRTHSEQLSVFLK NKR*" /label="ykoX CDS" gene 1322240..1322905 /gene="ykoX" /locus_tag="BSU_13430" /old_locus_tag="BSU13430" /label="ykoX gene" promotor_-10 complement(1322774..1322793) /Source="Nicolas_upshift_promotors" /id="U1086" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1257 /SigmaFactorBS="cctctttttcatcagtaagtagagcaggaacagcgCCAAAAT CGCtatcccgatcggaAGCATATATTGATCAAGAATagagccgactgccttccaattt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1322791) /Source="Nicolas_upshifts" /id="U1086" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1257 /SigmaFactorBS="cctctttttcatcagtaagtagagcaggaacagcgCCAAAAT CGCtatcccgatcggaAGCATATATTGATCAAGAATagagccgactgccttccaattt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1322807..1322816) /Source="Nicolas_upshift_promotors" /id="U1086" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1257 /SigmaFactorBS="cctctttttcatcagtaagtagagcaggaacagcgCCAAAAT CGCtatcccgatcggaAGCATATATTGATCAAGAATagagccgactgccttccaattt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1322900..1322907 /Source="Nicolas_upshift_promotors" /id="U1087" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.952047952047952" /psig=1 /xcortree=600 /SigmaFactorBS="attatctgtatttttgaaaaataaaCGTTGACAaatcactgc gctgcGCATATTATTGACGTATAAAatcatatttcttgaaatcccaaaggggagtagc g" /listShort="ykoY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1322922..1322941 /Source="Nicolas_upshift_promotors" /id="U1087" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.952047952047952" /psig=1 /xcortree=600 /SigmaFactorBS="attatctgtatttttgaaaaataaaCGTTGACAaatcactgc gctgcGCATATTATTGACGTATAAAatcatatttcttgaaatcccaaaggggagtagc g" /listShort="ykoY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1322935 /Source="Nicolas_upshifts" /id="U1087" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.952047952047952" /psig=1 /xcortree=600 /SigmaFactorBS="attatctgtatttttgaaaaataaaCGTTGACAaatcactgc gctgcGCATATTATTGACGTATAAAatcatatttcttgaaatcccaaaggggagtagc g" /listShort="ykoY" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 1322961..1323094 /gene="mnrW" /locus_tag="BSU_misc_RNA_87" /product="manganese ion riboswitch" /experiment="publication(s) with functional evidences, PMID:25794618, 25794619" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25794618, 25794619; Product type n: RNA" /function="16.12: Sense" /function="16.3: Control" /label="mnrW RNA" gene 1322961..1323094 /gene="mnrW" /locus_tag="BSU_misc_RNA_87" /label="mnrW gene" CDS 1322982..1323956 /gene="ykoY" /locus_tag="BSU_13440" /old_locus_tag="BSU13440" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15096624, 15849754, 16850406, 25794618, 25794619; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative manganese-related ion transporter" /protein_id="NP_389227.1" /db_xref="EnsemblGenomes-Gn:BSU13440" /db_xref="EnsemblGenomes-Tr:CAB13201" /db_xref="GOA:O34997" /db_xref="InterPro:IPR005496" /db_xref="InterPro:IPR022493" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13268" /db_xref="UniProtKB/Swiss-Prot:O34997" /translation="MYSGNKVVISWIVSIGFVGMPEFMSSKTFALCRQRSFLHGPAGI RSDEEKENNFFGRVSFMDAALLLEYGWVLLVLIGLEGILAADNALVMAVMVKHLPEEK RKKALFYGLAGAFVLRFGSLFAISFLVNVWQVQAIGAIYLLYISASHLLKRYVFKKED THKETKQSGFWPTVLKVELADIAFAVDSILAAVALAVTLPGTSLPKIGGLDGGQFLVI LAGGIIGLVIMRFAASMFVKLLKERPSLETAAFVIVGWVGVKLALYTLAHRDIAVVSE HFIHSGTWKLIFWGVLAAIAVCGWFMSGGKKQPEGAQNEQKNSTRERA*" /label="ykoY CDS" gene 1322982..1323956 /gene="ykoY" /locus_tag="BSU_13440" /old_locus_tag="BSU13440" /label="ykoY gene" downshifts 1323045 /Source="Nicolas_upshifts" /id="D736" /incds=1 /nref=38 /ntot=211 /MaxReadThrough="5.00041" /MaxDrop="4.46498" /score="15.8563987" /energy="-15" /TU="U1085,U1087" /idTUdmin="U1085" /TUdmin="-902" /isTUend="FALSE" /label="downshifts" downshifts 1323944 /Source="Nicolas_upshifts" /id="D737" /incds=0 /nref=16 /ntot=175 /MaxReadThrough="2.59801" /MaxDrop="4.20782" /score="24.4740487" /energy="-13.7" /TU="NA" /idTUdmin="U1085" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" promotor_-35 1324066..1324074 /Source="Nicolas_upshift_promotors" /id="U1088" /multdbtbs="SigI" /comp="M2" /sig="SigI" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1768 /SigmaFactorBS="atctttgttacaaaaaacacgcataaaaCCCCCTTAAttctt tagaaaggCACGAAATCatgtatagaacgtcagaatggtttgtcataattgagacatt g" /listShort="S480, sigI, rsgI, S481" /listLong="htpX" /label="promotor_-35" promotor_-10 1324088..1324096 /Source="Nicolas_upshift_promotors" /id="U1088" /multdbtbs="SigI" /comp="M2" /sig="SigI" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1768 /SigmaFactorBS="atctttgttacaaaaaacacgcataaaaCCCCCTTAAttctt tagaaaggCACGAAATCatgtatagaacgtcagaatggtttgtcataattgagacatt g" /listShort="S480, sigI, rsgI, S481" /listLong="htpX" /label="promotor_-10" upshifts 1324098 /Source="Nicolas_upshifts" /id="U1088" /multdbtbs="SigI" /comp="M2" /sig="SigI" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1768 /SigmaFactorBS="atctttgttacaaaaaacacgcataaaaCCCCCTTAAttctt tagaaaggCACGAAATCatgtatagaacgtcagaatggtttgtcataattgagacatt g" /listShort="S480, sigI, rsgI, S481" /listLong="htpX" /label="upshifts" S_feature 1324101..1324187 /Source="Nicolas_S_feature" /locus_tag="new_1411773_1411859" /HighExp="M9-stat, T1.30H, T1.0H, T0.30H, T2.0H, T2.30H, HiTm, M0t90, T3.0H, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.29969800000000002" /TUshortSig="SigI" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S480" promotor_-35 1324160..1324167 /Source="Nicolas_upshift_promotors" /id="U1089" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.809190809190809" /psig=1 /xcortree=1635 /SigmaFactorBS="tgagacattggaaatcaatatttctttttctCCTTTGCGaat ccctatcaaaTTAGCTATCATTAATGAGTAgttatagggaggaactgaggtgaaacca g" /listShort="sigI, rsgI, S481" /listLong="htpX" /label="promotor_-35" promotor_-10 1324181..1324200 /Source="Nicolas_upshift_promotors" /id="U1089" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.809190809190809" /psig=1 /xcortree=1635 /SigmaFactorBS="tgagacattggaaatcaatatttctttttctCCTTTGCGaat ccctatcaaaTTAGCTATCATTAATGAGTAgttatagggaggaactgaggtgaaacca g" /listShort="sigI, rsgI, S481" /listLong="htpX" /label="promotor_-10" upshifts 1324189 /Source="Nicolas_upshifts" /id="U1089" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.809190809190809" /psig=1 /xcortree=1635 /SigmaFactorBS="tgagacattggaaatcaatatttctttttctCCTTTGCGaat ccctatcaaaTTAGCTATCATTAATGAGTAgttatagggaggaactgaggtgaaacca g" /listShort="sigI, rsgI, S481" /listLong="htpX" /label="upshifts" CDS 1324220..1324975 /gene="sigI" /locus_tag="BSU_13450" /old_locus_tag="BSU13450" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11157964, 12682299, 17185538, 18156261, 21541672, 24125693, 28333276" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11157964, 12682299, 17185538, 18156261, 21541672, 24125693, 28333276; Product type f: factor" /codon_start=1 /transl_table=11 /product="RNA polymerase sigma factor (heat stress responsive)" /protein_id="NP_389228.1" /db_xref="EnsemblGenomes-Gn:BSU13450" /db_xref="EnsemblGenomes-Tr:CAB13218" /db_xref="GOA:O31654" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014244" /db_xref="InterPro:IPR014284" /db_xref="SubtiList:BG13269" /db_xref="UniProtKB/Swiss-Prot:O31654" /translation="MKPVLSLLFKLGKKKQTLEKAVESIQKGNKDLQNELIQQYKPFI AKTVSSVCKRYIDEKDDEFSIGLIAFNEAIEKYSPEKGNSLLAFAELIIKRKVIDYIR KEARSAQNINIDLQEGDDQESSQSLIEAELSIDEYRRQIEQEQRREEILYFQKQLKDY GLSFKELLENSPKHTDARQNAIKVAMTLVEHEELAAILYTKKQLPVKQLEQLVSVSRK TIERNRKYIIAMCIIITGDYIYLKDYLKGVLHS*" /label="sigI CDS" gene 1324220..1324975 /gene="sigI" /locus_tag="BSU_13450" /old_locus_tag="BSU13450" /label="sigI gene" CDS 1324972..1326117 /gene="rsgI" /locus_tag="BSU_13460" /old_locus_tag="BSU13460" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17185538, 23199363, 28333276" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17185538, 23199363, 28333276; Product type f: factor" /codon_start=1 /transl_table=11 /product="sigmaI modulating factor" /protein_id="NP_389229.1" /db_xref="EnsemblGenomes-Gn:BSU13460" /db_xref="EnsemblGenomes-Tr:CAB13219" /db_xref="GOA:O31655" /db_xref="InterPro:IPR024449" /db_xref="SubtiList:BG13272" /db_xref="UniProtKB/Swiss-Prot:O31655" /translation="MRRGIIVEKNKKFVTLLTPDGQFLKAKNDRHSYEIGEEIMLPSE TRMGRRASFFDFFKLRPFKMGIFTMTAIMLFIFIVLPVFSNNKAYAYMTIDINPSVEM ALNSDYEVIELTPLNDEGQKVVNDIDDWEKTDFKKVIDDIITDCSEHGYVKKSKEILI STVYENTEDNTYKKAVKKQLNDVTEKYKTTYRMESLESDMQTREKAKKEGVSTGSYIK SNEKNDNKDIKDDSSKPSGEEDQKSDENEDENTDQTDTQDSKQGDNEQLNDADSGDQK EEKADDQIDDSDKDKKIKESDENTNTEKDGDHEQTPIQDPQDKGNENNGADKGQSQYH RDWNNGEQGKNRSSSRRDNASDRRNPNGYSSDNHSAKNEDSPSAPGE*" /label="rsgI CDS" gene 1324972..1326117 /gene="rsgI" /locus_tag="BSU_13460" /old_locus_tag="BSU13460" /label="rsgI gene" S_feature 1326118..1327277 /Source="Nicolas_S_feature" /locus_tag="new_1413790_1414949" /HighExp="HiTm, G135, G180, C30, G150, Cold, S8, MG 25, H2O2, Lbstat" /AntisenseName="ykrK" /AntisenseCor="0.122248209149143" /AntisenseRegPval="-1.3" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigI" /TUshortPSig="1, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S481" CDS complement(1326128..1326322) /gene="sspD" /locus_tag="BSU_13470" /old_locus_tag="BSU13470" /function="16.5: Explore" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:3009397, 3112127, 3121585, 9852018" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3009397, 3112127, 3121585, 9852018; Product type f: factor" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein (alpha/beta-type SASP)" /protein_id="NP_389230.1" /db_xref="EnsemblGenomes-Gn:BSU13470" /db_xref="EnsemblGenomes-Tr:CAB13220" /db_xref="GOA:P04833" /db_xref="InterPro:IPR001448" /db_xref="InterPro:IPR018126" /db_xref="SubtiList:BG10788" /db_xref="UniProtKB/Swiss-Prot:P04833" /translation="MASRNKLVVPGVEQALDQFKLEVAQEFGVNLGSDTVARANGSVG GEMTKRLVQQAQSQLNGTTK*" /label="sspD CDS" gene complement(1326128..1326322) /gene="sspD" /locus_tag="BSU_13470" /old_locus_tag="BSU13470" /label="sspD gene" downshifts complement(1326135) /Source="Nicolas_upshifts" /id="D738" /incds=0 /nref=24 /ntot=36 /MaxReadThrough="1.67859" /MaxDrop="4.68215" /score="41.3727153" /energy="-15.2" /TU="NA" /idTUdmin="U1090" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1326365..1326376) /Source="Nicolas_upshift_promotors" /id="U1090" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=868 /SigmaFactorBS="cagaggccggggttttatttttctccacaacaattgccAGCA TAAataaaccccgtataTTTCAAACTAAAtacgcgttaagaatttctttatcgaaaaa g" /listShort="sspD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1326375) /Source="Nicolas_upshifts" /id="U1090" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=868 /SigmaFactorBS="cagaggccggggttttatttttctccacaacaattgccAGCA TAAataaaccccgtataTTTCAAACTAAAtacgcgttaagaatttctttatcgaaaaa g" /listShort="sspD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1326391..1326397) /Source="Nicolas_upshift_promotors" /id="U1090" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=868 /SigmaFactorBS="cagaggccggggttttatttttctccacaacaattgccAGCA TAAataaaccccgtataTTTCAAACTAAAtacgcgttaagaatttctttatcgaaaaa g" /listShort="sspD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1326453..1327154) /gene="htpK" /locus_tag="BSU_13480" /old_locus_tag="BSU13480" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:22447908, 23042994" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22447908, 23042994; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of quality control" /protein_id="NP_389231.1" /db_xref="EnsemblGenomes-Gn:BSU13480" /db_xref="EnsemblGenomes-Tr:CAB13221" /db_xref="InterPro:IPR014975" /db_xref="SubtiList:BG13273" /db_xref="UniProtKB/Swiss-Prot:O31656" /translation="MNIFKLSRTDMVRLLYSLKGQGEHSPLDILVQSANMSAEKAANH LEIPEFLTRYERKKQKKEYGLSTNEIVELGNLCELTSLKSTAIQNWVKRDIKDLIGHP ELGKKYSIEQAVILLIVRDLKSIYDFEHIRAILKVAFNTISDRSDDVISPIAYYESCA YVLDAIHHQDTPSMKESNLQEIAEQETERLRHRFEELNDSQWLKIRQIIAITVLSILT FHIQATAHKMTADIL*" /label="htpK CDS" gene complement(1326453..1327154) /gene="htpK" /locus_tag="BSU_13480" /old_locus_tag="BSU13480" /label="htpK gene" downshifts complement(1326487) /Source="Nicolas_upshifts" /id="D739" /incds=0 /nref=174 /ntot=231 /MaxReadThrough="2.96889" /MaxDrop="5.30355" /score="41.3727153" /energy="-15.2" /TU="NA" /idTUdmin="U1091" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1327155..1327235) /Source="Nicolas_S_feature" /locus_tag="new_1414827_1414907_c" /HighExp="LBGtran, dia0, LBGexp, Lbexp, Oxctl, G180, M0t45, C90, Paraq, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S482" promotor_-10 complement(1327227..1327246) /Source="Nicolas_upshift_promotors" /id="U1091" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=2572 /SigmaFactorBS="aacccgtatatttaaattataaaacatcCATTTGAAaatgca aggaattCGACGTATGATGTTAATGTAatttgctgacgcttgaattttgaacttatac a" /listShort="S482, ykrK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1327235) /Source="Nicolas_upshifts" /id="U1091" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=2572 /SigmaFactorBS="aacccgtatatttaaattataaaacatcCATTTGAAaatgca aggaattCGACGTATGATGTTAATGTAatttgctgacgcttgaattttgaacttatac a" /listShort="S482, ykrK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1327251..1327258 /Source="Nicolas_upshift_promotors" /id="U1092" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.898101898101898" /psig=1 /xcortree=1759 /SigmaFactorBS="cagcaaattacattaacatcatacgtcgaattCCTTGCATtt tcaaatggatgTTTTATAATTTAAATATACGggttcttttgaacttaaaataacggag g" /listShort="htpX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(1327260..1327267) /Source="Nicolas_upshift_promotors" /id="U1091" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=2572 /SigmaFactorBS="aacccgtatatttaaattataaaacatcCATTTGAAaatgca aggaattCGACGTATGATGTTAATGTAatttgctgacgcttgaattttgaacttatac a" /listShort="S482, ykrK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1327272..1327291 /Source="Nicolas_upshift_promotors" /id="U1092" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.898101898101898" /psig=1 /xcortree=1759 /SigmaFactorBS="cagcaaattacattaacatcatacgtcgaattCCTTGCATtt tcaaatggatgTTTTATAATTTAAATATACGggttcttttgaacttaaaataacggag g" /listShort="htpX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1327279 /Source="Nicolas_upshifts" /id="U1092" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.898101898101898" /psig=1 /xcortree=1759 /SigmaFactorBS="cagcaaattacattaacatcatacgtcgaattCCTTGCATtt tcaaatggatgTTTTATAATTTAAATATACGggttcttttgaacttaaaataacggag g" /listShort="htpX" /GFF_Attribute="listLong" /label="upshifts" CDS 1327325..1328221 /gene="htpX" /locus_tag="BSU_13490" /old_locus_tag="BSU13490" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11860552, 12081643, 16076848, 16573693, 22447908, 22720735; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="membrane protease" /protein_id="NP_389232.1" /db_xref="EnsemblGenomes-Gn:BSU13490" /db_xref="EnsemblGenomes-Tr:CAB13222" /db_xref="GOA:O31657" /db_xref="InterPro:IPR001915" /db_xref="InterPro:IPR022919" /db_xref="SubtiList:BG13274" /db_xref="UniProtKB/Swiss-Prot:O31657" /translation="MAKRIFLFILTNILVLTTIGIVLSVLSSVTGVGTYFTADGGIDP MALLVFSLVVGFVGSFTSLAISRWMAKTMMGVRVLNPKKHSLSYEEQQLVDRVHRLSR SAGLTKMPEVGIYRSPEVNAFATGPSKRRSLVAVSSGLLEQMDDAAVEGVLAHEVAHI TNGDMVTMTLLQGIVNTFVVFLSRIAAWIASRFVKEDLAPIVHFIAMIIFQIVFSILG SLVVFAYSRHREFHADRGGADLAGKDKMIHALRTLKSYSSRILEDDQTAVQTLKINGK KRSSLFSTHPDLDERIRRLEAK*" /label="htpX CDS" gene 1327325..1328221 /gene="htpX" /locus_tag="BSU_13490" /old_locus_tag="BSU13490" /label="htpX gene" downshifts 1328215 /Source="Nicolas_upshifts" /id="D740" /incds=0 /nref=203 /ntot=268 /MaxReadThrough="3.02778" /MaxDrop="6.27746" /score="38.5173589" /energy="-13.4" /TU="NA" /idTUdmin="U1092" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1328326..1328330 /Source="Nicolas_upshift_promotors" /id="U1093" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.617382617382617" /psig="0.994005994005994" /xcortree=2515 /SigmaFactorBS="aaaaaataagcaagttaagaaaatgtttcgtaaaagCCTTTa aaaatggacctaatATCTTTAGAATAATTACCGTacttaaaaagagaggcagaaggat t" /listShort="ktrD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1328346..1328365 /Source="Nicolas_upshift_promotors" /id="U1093" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.617382617382617" /psig="0.994005994005994" /xcortree=2515 /SigmaFactorBS="aaaaaataagcaagttaagaaaatgtttcgtaaaagCCTTTa aaaatggacctaatATCTTTAGAATAATTACCGTacttaaaaagagaggcagaaggat t" /listShort="ktrD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1328350 /Source="Nicolas_upshifts" /id="U1093" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.617382617382617" /psig="0.994005994005994" /xcortree=2515 /SigmaFactorBS="aaaaaataagcaagttaagaaaatgtttcgtaaaagCCTTTa aaaatggacctaatATCTTTAGAATAATTACCGTacttaaaaagagaggcagaaggat t" /listShort="ktrD" /GFF_Attribute="listLong" /label="upshifts" CDS 1328395..1329744 /gene="ktrD" /locus_tag="BSU_13500" /old_locus_tag="BSU13500" /EC_number="3.6.3.12" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12562800, 15096624, 15849754, 16850406, 23963175" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12562800, 15096624, 15849754, 16850406, 23963175; Product type t : transporter" /codon_start=1 /transl_table=11 /product="K+-transporting ATPase" /protein_id="NP_389233.1" /db_xref="EnsemblGenomes-Gn:BSU13500" /db_xref="EnsemblGenomes-Tr:CAB13223" /db_xref="GOA:O31658" /db_xref="InterPro:IPR003445" /db_xref="SubtiList:BG13275" /db_xref="UniProtKB/Swiss-Prot:O31658" /translation="MRLKFGKLIQALSPAQLIALYYFLAVTVAVILLSLPAAHKPGAD WTFIDALFTAVSSVSVTGLTVVDTADTFSTIGIFILAFVLQFGGIGIMTLGTFIWLIM GKRIGLKERKLIMVDQNQSQFSGIVNLMKQVLFLILWIEFFGGLILGTYFLTYYDSYQ EAYLHGFFASISATTNGGFDITGNSMIPFRHDYFVQFITMLLIIFGAIGFPVLVEVKD FLFSKHRRYPFTLFTKITTITFGSLVLFGAIGIFALEANHAFAGKSWHDILFLSLFQS TATRSGGLATIDISQLSDSTLFFICALMFIGASPSSVGGGIRTTTFALNLLALFHFAR GNKAVKVFKRELHPADLMKSLVVTMMAILLVFGATLILTITEKHSLLELLFEVCSAFG TTGLSLGITADLSSVGKCVIMIVMFIGRIGILTFLYLIGRKEIEANYHYPKERVIIG* " /label="ktrD CDS" gene 1328395..1329744 /gene="ktrD" /locus_tag="BSU_13500" /old_locus_tag="BSU13500" /label="ktrD gene" downshifts 1329732 /Source="Nicolas_upshifts" /id="D741" /incds=0 /nref=30 /ntot=182 /MaxReadThrough="0.838800000000001" /MaxDrop="4.37717" /score="20.0478288" /energy="-10.7" /TU="NA" /idTUdmin="U1093" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 1329793..1329799 /Source="Nicolas_upshift_promotors" /id="U1094" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=834 /SigmaFactorBS="tttgcggtgttttttgattaccaaaaaaaagaTGTGTGCctc ctgttcagttGGAGAACCTAACtccgacaggtgcaatttacgctcctgcatcttaaaa t" /listShort="S483, ykzP, ykzE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1329813..1329824 /Source="Nicolas_upshift_promotors" /id="U1094" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=834 /SigmaFactorBS="tttgcggtgttttttgattaccaaaaaaaagaTGTGTGCctc ctgttcagttGGAGAACCTAACtccgacaggtgcaatttacgctcctgcatcttaaaa t" /listShort="S483, ykzP, ykzE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1329821..1329888 /Source="Nicolas_S_feature" /locus_tag="new_1417493_1417560" /HighExp="S8, S6, S7, S5, ferm, nit, BT, B36, Pyr, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S483" upshifts 1329821 /Source="Nicolas_upshifts" /id="U1094" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=834 /SigmaFactorBS="tttgcggtgttttttgattaccaaaaaaaagaTGTGTGCctc ctgttcagttGGAGAACCTAACtccgacaggtgcaatttacgctcctgcatcttaaaa t" /listShort="S483, ykzP, ykzE" /GFF_Attribute="listLong" /label="upshifts" CDS 1329889..1330044 /gene="ykzP" /locus_tag="BSU_13509" /old_locus_tag="BSU13509" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097718.1" /db_xref="EnsemblGenomes-Gn:BSU13509" /db_xref="EnsemblGenomes-Tr:CAX52609" /db_xref="UniProtKB/Swiss-Prot:C0H402" /translation="MKRKAEVNEAIKNNNTPTESMDPNSYKTQYHDDPNFRGANRNSK QGQQGGM*" /label="ykzP CDS" gene 1329889..1330044 /gene="ykzP" /locus_tag="BSU_13509" /old_locus_tag="BSU13509" /label="ykzP gene" CDS 1330047..1330223 /gene="ykzE" /locus_tag="BSU_13510" /old_locus_tag="BSU13510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 17322312" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389234.1" /db_xref="EnsemblGenomes-Gn:BSU13510" /db_xref="EnsemblGenomes-Tr:CAB13224" /db_xref="SubtiList:BG13333" /db_xref="UniProtKB/Swiss-Prot:O31659" /translation="MKKNRHSRDMQNHKKPMNKKVLEEEFSSELGDYNAGKIIETLEV TKPEKKKEKNKKQQ*" /label="ykzE CDS" gene 1330047..1330223 /gene="ykzE" /locus_tag="BSU_13510" /old_locus_tag="BSU13510" /label="ykzE gene" promotor_no_box 1330113..1330213 /Source="Nicolas_upshift_promotors" /id="U1095" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.683316683316683" /psig="0.005994005994006" /xcortree=278 /SigmaFactorBS="gaggaagaattctcaagtgaactcggggattacaatgccgga aagatcatcgaaacgctggaagtcaccaagcctgaaaagaaaaaagaaaaaaacaaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 1330173 /Source="Nicolas_upshifts" /id="U1095" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.683316683316683" /psig="0.005994005994006" /xcortree=278 /SigmaFactorBS="gaggaagaattctcaagtgaactcggggattacaatgccgga aagatcatcgaaacgctggaagtcaccaagcctgaaaagaaaaaagaaaaaaacaaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1330219 /Source="Nicolas_upshifts" /id="D742" /incds=0 /nref=56 /ntot=112 /MaxReadThrough="2.40289" /MaxDrop="8.38761" /score="26.5107018" /energy="-19.7" /TU="NA" /idTUdmin="U1094" /TUdmin=2 /isTUend="TRUE" /label="downshifts" CDS complement(1330266..1331288) /gene="ykrP" /locus_tag="BSU_13520" /old_locus_tag="BSU13520" /EC_number="2.3.-.-" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative integral membrane protein; putative acyltransferase" /protein_id="NP_389235.1" /db_xref="EnsemblGenomes-Gn:BSU13520" /db_xref="EnsemblGenomes-Tr:CAB13225" /db_xref="GOA:O31660" /db_xref="InterPro:IPR002656" /db_xref="SubtiList:BG13276" /db_xref="UniProtKB/Swiss-Prot:O31660" /translation="MSKSRDSYFDNAKFLLIFLVVFGHILRSFINDNHFMLYLYKFIY TFHMPAFILVSGYFAKGFKRAGYVKKLAVKLIIPYLIFQIIYSVFYYIMQDESMANVN PIDPQWSLWFLVSLFFWNLLLYPFSKLSKQWALFVSCGIAVLIGYLDFVSSTLSLSRT FVFLPMFLVGFYLNKHHFDLLRSKRGKQIALGVLAAVFVICWGIDFDYSFLFGSKPYS SFGDVTLVSGLSRIGWYVLAFGATFSFLALVPQKRYFFTKWGTRTFYVYLLHGFIIKT LRQVGLEDWLTDYQSLVILLLLTAALTSVLSSNFVKTVAQPFIELRMTSLLQFVRGTG KNAYLK*" /label="ykrP CDS" gene complement(1330266..1331288) /gene="ykrP" /locus_tag="BSU_13520" /old_locus_tag="BSU13520" /label="ykrP gene" downshifts complement(1330289) /Source="Nicolas_upshifts" /id="D743" /incds=0 /nref=11 /ntot=58 /MaxReadThrough="2.29259" /MaxDrop="3.64731" /score="30.4184602" /energy="-16.9" /TU="NA" /idTUdmin="U1096" /TUdmin=92 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1331333..1331352) /Source="Nicolas_upshift_promotors" /id="U1096" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.816183816183816" /psig="0.987012987012987" /xcortree=580 /SigmaFactorBS="ccgtcactttacatcgacctaacaatcagcatttttttaGAT TCCTttttcatctttTATTTTAAAATATGTACCAGcagggaataatctcttagtgact g" /listShort="ykrP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1331349) /Source="Nicolas_upshifts" /id="U1096" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.816183816183816" /psig="0.987012987012987" /xcortree=580 /SigmaFactorBS="ccgtcactttacatcgacctaacaatcagcatttttttaGAT TCCTttttcatctttTATTTTAAAATATGTACCAGcagggaataatctcttagtgact g" /listShort="ykrP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1331364..1331370) /Source="Nicolas_upshift_promotors" /id="U1096" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.816183816183816" /psig="0.987012987012987" /xcortree=580 /SigmaFactorBS="ccgtcactttacatcgacctaacaatcagcatttttttaGAT TCCTttttcatctttTATTTTAAAATATGTACCAGcagggaataatctcttagtgact g" /listShort="ykrP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1331477..1331485 /Source="Nicolas_upshift_promotors" /id="U1097" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=548 /SigmaFactorBS="gtaatgtaatgacgctgaaattttctgaaatttatagggcaa atGAAGGAAGTtcccgcatttTGTAGAAATATTGAGGGATaggttttgaagaaggagt g" /listShort="kinE, ogt, S485" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1331493 /Source="Nicolas_upshifts" /id="U1097" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=548 /SigmaFactorBS="gtaatgtaatgacgctgaaattttctgaaatttatagggcaa atGAAGGAAGTtcccgcatttTGTAGAAATATTGAGGGATaggttttgaagaaggagt g" /listShort="kinE, ogt, S485" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1331496..1331514 /Source="Nicolas_upshift_promotors" /id="U1097" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=548 /SigmaFactorBS="gtaatgtaatgacgctgaaattttctgaaatttatagggcaa atGAAGGAAGTtcccgcatttTGTAGAAATATTGAGGGATaggttttgaagaaggagt g" /listShort="kinE, ogt, S485" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1331541..1333757 /gene="kinE" /locus_tag="BSU_13530" /old_locus_tag="BSU13530" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11069677, 12169614, 16166384, 25701730" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11069677, 12169614, 16166384, 25701730; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase" /protein_id="NP_389236.1" /db_xref="EnsemblGenomes-Gn:BSU13530" /db_xref="EnsemblGenomes-Tr:CAB13226" /db_xref="GOA:O31661" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR013767" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG13277" /db_xref="UniProtKB/Swiss-Prot:O31661" /translation="METLGVQTNSELREELNRLKEENARLKKELNQHQVIVNNTLDAI FICDNEMRIVQANEATERMLQVDSEDLKKRSVLDFLFSIPKDELNLSVKKFFKKGFLW KEVPIRLDCGATKYIEFLAKRGIGEDFFFVVMRDISSKKILEREFSMNEQLFKDLFDR AVDGIVLFDKDGGFIDANLSFCKSFEINHNELSHLSLYEFIDSGSRKDFDNIWKALNR KGKAKGELPVKLRSGVQKLFEFTITSNIISGFYMSIMRDITEKRSMELQLFKSEERFR EIFENAMDAIIIWSNDGRIVKANQSACKIFELPMNLLLKRKLCDFLVDSQQKYSITKR KYAKYGEIREELLFQMGNGQFKELEFTSKRTILENQHLTILRNVSDRKRMEKELRESE LKFRKVFNGSMDGNVLFDNQYRIIDANPLASHILGLSHEEIKQHSLLDIISAYEIENL ASPARQINFDEMDNEIPFLLSSGDNRKLEFSFKRNIIQNMNLAIFKDVTERKELEERL RKSDTLHVVGELAAGIAHEIRNPMTALKGFIQLLKGSVEGDYALYFNVITSELKRIES IITEFLILAKPQAIMYEEKHVTQIMRDTIDLLNAQANLSNVQMQLDLIDDIPPIYCEP NQLKQVFINILKNAIEVMPDGGNIFVTIKALDQDHVLISLKDEGIGMTEDKLKRLGEP FYTTKERGTGLGLMVSYKIIEEHQGEIMVESEEGKGTVFHITLPVRQNAEERRNDE*" /label="kinE CDS" gene 1331541..1333757 /gene="kinE" /locus_tag="BSU_13530" /old_locus_tag="BSU13530" /label="kinE gene" S_feature complement(1333532..1334472) /Source="Nicolas_S_feature" /locus_tag="new_1421204_1422144_c" /HighExp="Pyr, Glucon, C30, Glu, Mal, M/G, G/S, Heat, Fru, B36" /AntisenseName="ogt" /AntisenseCor="-0.33210294457391598" /AntisenseRegPval="-7.6" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S484" promotor_-35 1333610..1333617 /Source="Nicolas_upshift_promotors" /id="U1098" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.999000999001" /xcortree=2063 /SigmaFactorBS="acttggtgaaccgttttatacgacaaaggaacggggAACTGG ACttgggcttatggtaAGCTATAAAATTATTGAAGAacatcaaggcgagattatggta g" /listShort="ogt, S485" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1333632..1333651 /Source="Nicolas_upshift_promotors" /id="U1098" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.999000999001" /xcortree=2063 /SigmaFactorBS="acttggtgaaccgttttatacgacaaaggaacggggAACTGG ACttgggcttatggtaAGCTATAAAATTATTGAAGAacatcaaggcgagattatggta g" /listShort="ogt, S485" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1333634 /Source="Nicolas_upshifts" /id="U1098" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.999000999001" /xcortree=2063 /SigmaFactorBS="acttggtgaaccgttttatacgacaaaggaacggggAACTGG ACttgggcttatggtaAGCTATAAAATTATTGAAGAacatcaaggcgagattatggta g" /listShort="ogt, S485" /GFF_Attribute="listLong" /label="upshifts" CDS 1333754..1334251 /gene="ogt" /locus_tag="BSU_13540" /old_locus_tag="BSU13540" /EC_number="2.1.1.63" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:2105461, 2308822, 2359121, 2506524, 7565865" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2105461, 2308822, 2359121, 2506524, 7565865; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="O6-alkylguanine DNA alkyltransferase" /protein_id="NP_389237.1" /db_xref="EnsemblGenomes-Gn:BSU13540" /db_xref="EnsemblGenomes-Tr:CAB13227" /db_xref="GOA:P11742" /db_xref="InterPro:IPR001497" /db_xref="InterPro:IPR008332" /db_xref="InterPro:IPR014048" /db_xref="InterPro:IPR023546" /db_xref="InterPro:IPR036217" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036631" /db_xref="SubtiList:BG10848" /db_xref="UniProtKB/Swiss-Prot:P11742" /translation="MNYYTTAETPLGELIIAEEEDRITRLFLSQEDWVDWKETVQNTE HKETPNLAEAKQQLQEYFAGERKTFSLPLSQKGTPFQQKVWQALERIPYGESRSYADI AAAVGSPKAVRAVGQANKRNDLPIFVPCHRVIGKNSALTGYAGSKTEIKAFLLNIERI SYKEK*" /label="ogt CDS" gene 1333754..1334251 /gene="ogt" /locus_tag="BSU_13540" /old_locus_tag="BSU13540" /label="ogt gene" S_feature 1334252..1334491 /Source="Nicolas_S_feature" /locus_tag="new_1421924_1422163" /HighExp="Lbstat, S2, BT, BC, LPhT, dia15, LBGstat, M0t90, M9-stat, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.981549" /TUshortSig="SigA, SigH" /TUshortPSig="0.999, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S485" CDS 1334341..1334466 /locus_tag="BSU_13545" /old_locus_tag="BSU13545" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513954.1" /translation="MKPSRSEKLAVFAELFVKLHILSSAQKDEIINVNKKKQKNR*" /label="hypothetical protein CDS" gene 1334341..1334466 /locus_tag="BSU_13545" /old_locus_tag="BSU13545" /label="gene" downshifts 1334459 /Source="Nicolas_upshifts" /id="D744" /incds=0 /nref=80 /ntot=239 /MaxReadThrough="1.90528" /MaxDrop="5.2481" /score="4.84132266" /energy="-15.5" /TU="NA" /idTUdmin="U1097" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS complement(1334500..1335561) /gene="mtnA" /locus_tag="BSU_13550" /old_locus_tag="BSU13550" /EC_number="5.3.1.23" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14551435, 15102328, 16511105, 17690466, 18156470" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14551435, 15102328, 16511105, 17690466, 18156470; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylthioribose-1-phosphate isomerase (methionine salvage pathway)" /protein_id="NP_389238.1" /db_xref="EnsemblGenomes-Gn:BSU13550" /db_xref="EnsemblGenomes-Tr:CAB13228" /db_xref="GOA:O31662" /db_xref="InterPro:IPR000649" /db_xref="InterPro:IPR005251" /db_xref="InterPro:IPR011559" /db_xref="InterPro:IPR027363" /db_xref="PDB:2YRF" /db_xref="PDB:2YVK" /db_xref="SubtiList:BG13278" /db_xref="UniProtKB/Swiss-Prot:O31662" /translation="MTHSFAVPRSVEWKETAITILNQQKLPDETEYLELTTKEDVFDA IVTLKVRGAPAIGITAAFGLALAAKDIETDNVTEFRRRLEDIKQYLNSSRPTAINLSW ALERLSHSVENAISVNEAKTNLVHEAIQIQVEDEETCRLIGQNALQLFKKGDRIMTIC NAGSIATSRYGTALAPFYLAKQKDLGLHIYACETRPVLQGSRLTAWELMQGGIDVTLI TDSMAAHTMKEKQISAVIVGADRIAKNGDTANKIGTYGLAILANAFDIPFFVAAPLST FDTKVKCGADIPIEERDPEEVRQISGVRTAPSNVPVFNPAFDITPHDLISGIITEKGI MTGNYEEEIEQLFKGEKVH*" /label="mtnA CDS" gene complement(1334500..1335561) /gene="mtnA" /locus_tag="BSU_13550" /old_locus_tag="BSU13550" /label="mtnA gene" downshifts complement(1334517) /Source="Nicolas_upshifts" /id="D745" /incds=0 /nref=261 /ntot=286 /MaxReadThrough="4.47312" /MaxDrop="7.97339" /score="34.04363" /energy="-17.1" /TU="U1099,U1102" /idTUdmin="U1102" /TUdmin="-418" /isTUend="FALSE" /label="downshifts" CDS complement(1335569..1336762) /gene="mtnK" /locus_tag="BSU_13560" /old_locus_tag="BSU13560" /EC_number="2.7.1.100" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:210167, 11545674, 15102328, 17522047, 23649237" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 210167, 11545674, 15102328, 17522047, 23649237; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylthioribose kinase (methionine salvage pathway, promiscuous)" /protein_id="NP_389239.2" /db_xref="EnsemblGenomes-Gn:BSU13560" /db_xref="EnsemblGenomes-Tr:CAB13229" /db_xref="GOA:O31663" /db_xref="InterPro:IPR002575" /db_xref="InterPro:IPR009212" /db_xref="InterPro:IPR011009" /db_xref="PDB:2OLC" /db_xref="PDB:2PU8" /db_xref="PDB:2PUI" /db_xref="PDB:2PUL" /db_xref="PDB:2PUN" /db_xref="PDB:2PUP" /db_xref="SubtiList:BG13279" /db_xref="UniProtKB/Swiss-Prot:O31663" /translation="MGVTKTPLYETLNESSAVALAVKLGLFPSKSTLTCQEIGDGNLN YVFHIYDQEHDRALIIKQAVPYAKVVGESWPLTIDRARIESSALIRQGEHVPHLVPRV FYSDTEMAVTVMEDLSHLKIARKGLIEGENYPHLSQHIGEFLGKTLFYSSDYALEPKV KKQLVKQFTNPELCDITERLVFTDPFFDHDTNDFEEELRPFVEKLWNNDSVKIEAAKL KKSFLTSAETLIHGDLHTGSIFASEHETKVIDPEFAFYGPIGFDVGQFIANLFLNALS RDGADREPLYEHVNQVWETFEETFSEAWQKDSLDVYANIDGYLTDTLSHIFEEAIGFA GCELIRRTIGLAHVADLDTIVPFDKRIGRKRLALETGTAFIEKRSEFKTITDVIELFK LLVKE*" /label="mtnK CDS" gene complement(1335569..1336762) /gene="mtnK" /locus_tag="BSU_13560" /old_locus_tag="BSU13560" /label="mtnK gene" downshifts 1335629 /Source="Nicolas_upshifts" /id="D746" /incds=1 /nref=1 /ntot=51 /MaxReadThrough="3.02938" /MaxDrop="3.49719" /score="4.84132266" /energy="-15.5" /TU="NA" /idTUdmin="U1097" /TUdmin=1166 /isTUend="FALSE" /label="downshifts" downshifts complement(1336849) /Source="Nicolas_upshifts" /id="D747" /incds=0 /nref=1 /ntot=1 /MaxReadThrough="8.61071" /MaxDrop="3.05641" /score="27.7981655" /energy="-17.6" /TU="U1099,U1102" /idTUdmin="U1102" /TUdmin="-2750" /isTUend="FALSE" /label="downshifts" misc_RNA complement(1336855..1337011) /gene="mswC" /locus_tag="BSU_misc_RNA_20" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 15102328, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 15102328, 17381305, 18039762; Product type n : RNA" /function="12: Regulatory functions" /label="mswC RNA" gene complement(1336855..1337011) /gene="mswC" /locus_tag="BSU_misc_RNA_20" /label="mswC gene" promotor_-10 complement(1337046..1337065) /Source="Nicolas_upshift_promotors" /id="U1099" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2894 /SigmaFactorBS="agatttatattaaaaaataTATTGACAactaactaaattacc TGTTACCATGTTCATCAACTgataaattagaattgtcaaacaagtgaatatattctct t" /listShort="NA, mtnK, mtnA, S484" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1337047) /Source="Nicolas_upshifts" /id="U1099" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2894 /SigmaFactorBS="agatttatattaaaaaataTATTGACAactaactaaattacc TGTTACCATGTTCATCAACTgataaattagaattgtcaaacaagtgaatatattctct t" /listShort="NA, mtnK, mtnA, S484" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1337081..1337088) /Source="Nicolas_upshift_promotors" /id="U1099" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2894 /SigmaFactorBS="agatttatattaaaaaataTATTGACAactaactaaattacc TGTTACCATGTTCATCAACTgataaattagaattgtcaaacaagtgaatatattctct t" /listShort="NA, mtnK, mtnA, S484" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1337091..1337094 /Source="Nicolas_upshift_promotors" /id="U1100" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.276723276723277" /psig="0.98001998001998" /xcortree=2865 /SigmaFactorBS="ggtaacaggtaatttagttagttgtcaatataTTTTttaata taaatctttTCTGATATCATCGAAAACAGgaatgctctcccgaacttctgcgctttct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1337095..1337874) /gene="mtnU" /locus_tag="BSU_13570" /old_locus_tag="BSU13570" /EC_number="3.5.1.3" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12022921, 19464248, 19596042, 21288482, 23944997, 24387040; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ketoglutaramate omega-amidase" /protein_id="NP_389240.1" /db_xref="EnsemblGenomes-Gn:BSU13570" /db_xref="EnsemblGenomes-Tr:CAB13230" /db_xref="GOA:O31664" /db_xref="InterPro:IPR003010" /db_xref="InterPro:IPR036526" /db_xref="SubtiList:BG13280" /db_xref="UniProtKB/Swiss-Prot:O31664" /translation="MKWTISCLQFDISYGKPSENIKKAEFFIEKESKHADVLVLPELW TTGYDLANLDELADEDGRSAQSWLKKTAKKHGVHIVAGSVAVRKNSDVYNTMYIADKE GQIIKEYRKAHLFQLMDEHLYLSAGSEDGYFELDGVKSSGLICYDIRFPEWIRKHTTK GANVLFISAEWPLPRLDHWKSLLIARAIENQCFVAACNCTGSNPDNEFAGHSLIIDPW GRVLAEGGREEGIVRAEIDLQESAEVRESIPVFDDIRKDLY*" /label="mtnU CDS" gene complement(1337095..1337874) /gene="mtnU" /locus_tag="BSU_13570" /old_locus_tag="BSU13570" /label="mtnU gene" promotor_-10 1337110..1337129 /Source="Nicolas_upshift_promotors" /id="U1100" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.276723276723277" /psig="0.98001998001998" /xcortree=2865 /SigmaFactorBS="ggtaacaggtaatttagttagttgtcaatataTTTTttaata taaatctttTCTGATATCATCGAAAACAGgaatgctctcccgaacttctgcgctttct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1337119 /Source="Nicolas_upshifts" /id="U1100" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.276723276723277" /psig="0.98001998001998" /xcortree=2865 /SigmaFactorBS="ggtaacaggtaatttagttagttgtcaatataTTTTttaata taaatctttTCTGATATCATCGAAAACAGgaatgctctcccgaacttctgcgctttct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1337567..1337574 /Source="Nicolas_upshift_promotors" /id="U1101" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.634365634365634" /psig="0.99100899100899" /xcortree=2893 /SigmaFactorBS="ttttctgtactctttaatgatttgcCCTTCCTTatccgcgat gtaCATTGTATTATAAACATCAGaattcttcctgacagcgaccgatccggcgacaata t" /listShort="S486, mtnE" /listLong="NA, mtnW, mtnX, mtnB, mtnD" /label="promotor_-35" promotor_-10 1337587..1337606 /Source="Nicolas_upshift_promotors" /id="U1101" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.634365634365634" /psig="0.99100899100899" /xcortree=2893 /SigmaFactorBS="ttttctgtactctttaatgatttgcCCTTCCTTatccgcgat gtaCATTGTATTATAAACATCAGaattcttcctgacagcgaccgatccggcgacaata t" /listShort="S486, mtnE" /listLong="NA, mtnW, mtnX, mtnB, mtnD" /label="promotor_-10" upshifts 1337602 /Source="Nicolas_upshifts" /id="U1101" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.634365634365634" /psig="0.99100899100899" /xcortree=2893 /SigmaFactorBS="ttttctgtactctttaatgatttgcCCTTCCTTatccgcgat gtaCATTGTATTATAAACATCAGaattcttcctgacagcgaccgatccggcgacaata t" /listShort="S486, mtnE" /listLong="NA, mtnW, mtnX, mtnB, mtnD" /label="upshifts" S_feature 1337609..1337926 /Source="Nicolas_S_feature" /locus_tag="new_1425281_1425598" /HighExp="LoTm, S8, C30, BC, S7, B36, B60, T2.0H, Sw, UNK1" /AntisenseName="mtnU" /AntisenseCor="0.77659263363209297" /AntisenseRegPval="-54.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.991" /TUlongSig="NA" /TUlongPSig="NA" /label="S486" promotor_-35 1337896..1337903 /Source="Nicolas_upshift_promotors" /id="U1103" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.929070929070929" /psig=1 /xcortree=3072 /SigmaFactorBS="atttcatctttttaacaccccaaattttTCTTTACTtttttc atttaaccATATATGATGATGGACTATCatttcaagatttttttagaaggtgagaata g" /listShort="mtnE, NA, mtnW, mtnX, mtnB, mtnD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1337904..1337923) /Source="Nicolas_upshift_promotors" /id="U1102" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.827172827172827" /psig=1 /xcortree=2895 /SigmaFactorBS="caaatttcatctattctcaccttctaaaaaaaTCTTGAAAtg atagtccatcatcATATATGGTTAAATGAAAAAagtaaagaaaaatttggggtgttaa a" /listShort="mtnU, NA, mtnK, mtnA, S484" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 1337918..1337937 /Source="Nicolas_upshift_promotors" /id="U1103" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.929070929070929" /psig=1 /xcortree=3072 /SigmaFactorBS="atttcatctttttaacaccccaaattttTCTTTACTtttttc atttaaccATATATGATGATGGACTATCatttcaagatttttttagaaggtgagaata g" /listShort="mtnE, NA, mtnW, mtnX, mtnB, mtnD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1337918) /Source="Nicolas_upshifts" /id="U1102" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.827172827172827" /psig=1 /xcortree=2895 /SigmaFactorBS="caaatttcatctattctcaccttctaaaaaaaTCTTGAAAtg atagtccatcatcATATATGGTTAAATGAAAAAagtaaagaaaaatttggggtgttaa a" /listShort="mtnU, NA, mtnK, mtnA, S484" /GFF_Attribute="listLong" /label="upshifts" upshifts 1337928 /Source="Nicolas_upshifts" /id="U1103" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.929070929070929" /psig=1 /xcortree=3072 /SigmaFactorBS="atttcatctttttaacaccccaaattttTCTTTACTtttttc atttaaccATATATGATGATGGACTATCatttcaagatttttttagaaggtgagaata g" /listShort="mtnE, NA, mtnW, mtnX, mtnB, mtnD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1337939..1337946) /Source="Nicolas_upshift_promotors" /id="U1102" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.827172827172827" /psig=1 /xcortree=2895 /SigmaFactorBS="caaatttcatctattctcaccttctaaaaaaaTCTTGAAAtg atagtccatcatcATATATGGTTAAATGAAAAAagtaaagaaaaatttggggtgttaa a" /listShort="mtnU, NA, mtnK, mtnA, S484" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1337969..1339165 /gene="mtnE" /locus_tag="BSU_13580" /old_locus_tag="BSU13580" /EC_number="2.6.1.1" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12670965, 15102328, 23429746, 24387040" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12670965, 15102328, 23429746, 24387040; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methionine-glutamine aminotransferase" /protein_id="NP_389241.1" /db_xref="EnsemblGenomes-Gn:BSU13580" /db_xref="EnsemblGenomes-Tr:CAB13231" /db_xref="GOA:O31665" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG13281" /db_xref="UniProtKB/Swiss-Prot:O31665" /translation="MKFEQSHVLKELPKQFFASLVQKVNRKLAEGHDVINLGQGNPDQ PTPEHIVEEMKRAVADPENHKYSSFRGSYRLKSAAAAFYKREYGIDLDPETEVAVLFG GKAGLVELPQCLLNPGDTILVPDPGYPDYWSGVTLAKAKMEMMPLVKDRAFLPDYSSI TAEIREQAKLMYLNYPNNPTGAVATSEFFEDTVRFAAENGICVVHDFAYGAVGFDGCK PLSFLQTEGAKDIGIEIYTLSKTYNMAGWRVGFAVGNASVIEAINLYQDHMFVSLFRA TQEAAAEALLADQTCVAEQNARYESRRNAWITACREIGWDVTAPAGSFFAWLPVPEGY TSEQFSDLLLEKANVAVAAGNGFGEYGEGYVRVGLLTSEERLKEAAYRIGKLNLFTQK SIDKTL*" /label="mtnE CDS" gene 1337969..1339165 /gene="mtnE" /locus_tag="BSU_13580" /old_locus_tag="BSU13580" /label="mtnE gene" promotor_-35 1339147..1339154 /Source="Nicolas_upshift_promotors" /id="U1104" /multdbtbs="SigA,SigA" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.998001998001998" /xcortree=2896 /SigmaFactorBS="acctgtttacccaaaaaagCATTGACAagaccttataacgaT GGGATAATTCAAAATAATTtataaaatctatattttcttatcaagagcaggcagaggg a" /listShort="NA, mtnW, mtnX, mtnB, mtnD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1339169..1339188 /Source="Nicolas_upshift_promotors" /id="U1104" /multdbtbs="SigA,SigA" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.998001998001998" /xcortree=2896 /SigmaFactorBS="acctgtttacccaaaaaagCATTGACAagaccttataacgaT GGGATAATTCAAAATAATTtataaaatctatattttcttatcaagagcaggcagaggg a" /listShort="NA, mtnW, mtnX, mtnB, mtnD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1339188 /Source="Nicolas_upshifts" /id="U1104" /multdbtbs="SigA,SigA" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.998001998001998" /xcortree=2896 /SigmaFactorBS="acctgtttacccaaaaaagCATTGACAagaccttataacgaT GGGATAATTCAAAATAATTtataaaatctatattttcttatcaagagcaggcagaggg a" /listShort="NA, mtnW, mtnX, mtnB, mtnD" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 1339204..1339304 /gene="mswD" /locus_tag="BSU_misc_RNA_21" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 15102328, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 15102328, 17381305, 18039762; Product type n : RNA" /function="16.3: Control" /label="mswD RNA" gene 1339204..1339304 /gene="mswD" /locus_tag="BSU_misc_RNA_21" /label="mswD gene" downshifts 1339303 /Source="Nicolas_upshifts" /id="D748" /incds=0 /nref=49 /ntot=190 /MaxReadThrough="7.27369" /MaxDrop="4.19981" /score="-1.80590532" /energy="-10.7" /TU="U1103,U1104" /idTUdmin="U1101" /TUdmin=110 /isTUend="FALSE" /label="downshifts" CDS 1339389..1340606 /gene="mtnW" /locus_tag="BSU_13590" /old_locus_tag="BSU13590" /EC_number="5.3.2.5" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12022921, 14551435, 15102328, 15950120, 16737967, 18403380" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12022921, 14551435, 15102328, 15950120, 16737967, 18403380; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="2,3-diketo-5-methylthiopentyl-1-phosphate enolase (DK-MTP-1-P enolase)" /protein_id="NP_389242.2" /db_xref="EnsemblGenomes-Gn:BSU13590" /db_xref="EnsemblGenomes-Tr:CAB13232" /db_xref="GOA:O31666" /db_xref="InterPro:IPR000685" /db_xref="InterPro:IPR017443" /db_xref="InterPro:IPR017717" /db_xref="InterPro:IPR033966" /db_xref="InterPro:IPR036376" /db_xref="InterPro:IPR036422" /db_xref="PDB:2ZVI" /db_xref="SubtiList:BG13282" /db_xref="UniProtKB/Swiss-Prot:O31666" /translation="MSELLATYLLTEPGADTEKKAEQIATGLTVGSWTDLPLVKQEQM QKHKGRVIKVEEREGTAASEKQAVITIAYPEINFSQDIPALLTTVFGKLSLDGKIKLI DLHFSEAFKRALPGPKFGVYGIRKLLGEFERPLLMSIFKGVIGRDLSDIKEQLRQQAL GGVDLIKDDEIFFETGLAPFETRIAEGKQILKETYEQTGHKTLYAVNLTGRTADLKDK ARRAAELGADALLFNVFAYGLDVMQGLAEDPEIPVPIMAHPAVSGAFTSSPFYGFSHA LLLGKLNRYCGADFSLFPSPYGSVALPRADALAIHEECVREDAFNQTFAVPSAGIHPG MVPLLMRDFGIDHIINAGGGVHGHPNGAQGGGRAFRAIIDAVLEAQPIDEKAEQCKDL KLALDKWGKAEAV*" /label="mtnW CDS" gene 1339389..1340606 /gene="mtnW" /locus_tag="BSU_13590" /old_locus_tag="BSU13590" /label="mtnW gene" CDS 1340603..1341310 /gene="mtnX" /locus_tag="BSU_13600" /old_locus_tag="BSU13600" /EC_number="3.1.3.87" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12022921, 14551435, 15102328, 15950120, 17654724" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12022921, 14551435, 15102328, 15950120, 17654724; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-hydroxy-3-keto-5-methylthiopentenyl-1- phosphatephosphatase (HK-MTPenyl-1-P phosphatase)" /protein_id="NP_389243.1" /db_xref="EnsemblGenomes-Gn:BSU13600" /db_xref="EnsemblGenomes-Tr:CAB13233" /db_xref="GOA:O31667" /db_xref="InterPro:IPR006384" /db_xref="InterPro:IPR017718" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="PDB:2FEA" /db_xref="SubtiList:BG13283" /db_xref="UniProtKB/Swiss-Prot:O31667" /translation="MTTRKPFIICDFDGTITMNDNIINIMKTFAPPEWMALKDGVLSK TLSIKEGVGRMFGLLPSSLKEEITSFVLEDAKIREGFREFVAFINEHEIPFYVISGGM DFFVYPLLEGIVEKDRIYCNHASFDNDYIHIDWPHSCKGTCSNQCGCCKPSVIHELSE PNQYIIMIGDSVTDVEAAKLSDLCFARDYLLNECREQNLNHLPYQDFYEIRKEIENVK EVQEWLQNKNAGESSLK*" /label="mtnX CDS" gene 1340603..1341310 /gene="mtnX" /locus_tag="BSU_13600" /old_locus_tag="BSU13600" /label="mtnX gene" CDS 1341268..1341897 /gene="mtnB" /locus_tag="BSU_13610" /old_locus_tag="BSU13610" /EC_number="4.2.1.109" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12022921, 14551435, 15102328, 18391471, 23285211" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12022921, 14551435, 15102328, 18391471, 23285211; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylthioribulose-1-phosphate dehydratase (MTRu-1-P dehydratase)" /protein_id="NP_389244.1" /db_xref="EnsemblGenomes-Gn:BSU13610" /db_xref="EnsemblGenomes-Tr:CAB13234" /db_xref="GOA:O31668" /db_xref="InterPro:IPR001303" /db_xref="InterPro:IPR017714" /db_xref="InterPro:IPR036409" /db_xref="SubtiList:BG13284" /db_xref="UniProtKB/Swiss-Prot:O31668" /translation="MAAKQERWRELAEVKRELAERDWFPATSGNLSIKVTDEPLTFLV TASGKDKRKETVEDFLLVDQNGEPAESGHSLKPSAETLLHTHLYNKTNAGCCLHVHTV NNNVISELYGDQKKITFKGQEIIKALGLWEENAEVTVPIIENPAHIPTLAALFAEEIS EDSGAVLIRNHGITAWGKTAFEAKRVLEAYEFLFSYHLKLKTLEHQLVK*" /label="mtnB CDS" gene 1341268..1341897 /gene="mtnB" /locus_tag="BSU_13610" /old_locus_tag="BSU13610" /label="mtnB gene" CDS 1341912..1342448 /gene="mtnD" /locus_tag="BSU_13620" /old_locus_tag="BSU13620" /EC_number="1.13.11.54" /EC_number="1.13.11.53" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10704478, 11371200, 12022880, 12022921, 12402029, 15102328, 16297065, 16783794, 24036122" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10704478, 11371200, 12022880, 12022921, 12402029, 15102328, 16297065, 16783794, 24036122; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acireductone dioxygenase (Ni2+ or Fe2+-requiring)" /protein_id="NP_389245.1" /db_xref="EnsemblGenomes-Gn:BSU13620" /db_xref="EnsemblGenomes-Tr:CAB13235" /db_xref="GOA:O31669" /db_xref="InterPro:IPR004313" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR023956" /db_xref="SubtiList:BG13285" /db_xref="UniProtKB/Swiss-Prot:O31669" /translation="MATIRIHDEANTTIENQEEVASFLDSQEVIYEQWDITRLPEHLS EKYDLTEEEKQQILDTFETEIKDISTRRGYKAQDVISLSDSNPKLDELLENFKREHHH TDDEVRFIVSGHGIFVIQGQDGTFFDVRLNPGDLISVPENIRHYFTLQEDRKVVAVRI FVTTEGWVPIYEKDSVNQ*" /label="mtnD CDS" gene 1341912..1342448 /gene="mtnD" /locus_tag="BSU_13620" /old_locus_tag="BSU13620" /label="mtnD gene" S_feature complement(1342295..1342488) /Source="Nicolas_S_feature" /locus_tag="new_1429967_1430160_c" /HighExp="Lbstat, Cold, LBGstat, T0.30H, M9-stat, B60, ferm, T1.30H, LPhT, M0t90" /AntisenseName="mtnD" /AntisenseCor="-0.31139057410816301" /AntisenseRegPval="-6.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S487" downshifts 1342448 /Source="Nicolas_upshifts" /id="D749" /incds=0 /nref=179 /ntot=227 /MaxReadThrough="1.58976" /MaxDrop="6.10661" /score="35.4563733" /energy="-14.9" /TU="NA" /idTUdmin="U1103" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1342489..1342809) /gene="ykvA" /locus_tag="BSU_13630" /old_locus_tag="BSU13630" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389246.1" /db_xref="EnsemblGenomes-Gn:BSU13630" /db_xref="EnsemblGenomes-Tr:CAB13236" /db_xref="GOA:O31670" /db_xref="InterPro:IPR010652" /db_xref="SubtiList:BG13308" /db_xref="UniProtKB/Swiss-Prot:O31670" /translation="MKKKKAIMLGAAGGKAILKRKNRKKCIQHITTFFQMLRDWRNGD YPRSQVKTLLLLTAAILYIVMPLDIIPDVILGLGFIDDAAVLGLIWTLIKKELSQYEK WRLQ*" /label="ykvA CDS" gene complement(1342489..1342809) /gene="ykvA" /locus_tag="BSU_13630" /old_locus_tag="BSU13630" /label="ykvA gene" downshifts complement(1342547) /Source="Nicolas_upshifts" /id="D750" /incds=0 /nref=5 /ntot=148 /MaxReadThrough="4.05831" /MaxDrop="2.74575" /score="18.5455371" /energy="-11.3" /TU="U1106" /idTUdmin="U1106" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" S_feature complement(1342810..1342899) /Source="Nicolas_S_feature" /locus_tag="new_1430482_1430571_c" /HighExp="Lbstat, M9-stat, B60, T0.30H, LBGstat, M0t90, T1.0H, S2, T3.0H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S488" promotor_-35 1342835..1342841 /Source="Nicolas_upshift_promotors" /id="U1105" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=237 /SigmaFactorBS="tcattgggcatacctcctgcctggcggcgTGTTTAAgatatt cttcacctGGGTATTGTTCTTCTAATCctatcaatatatctattatacctgaaaaatt a" /listShort="S489, S490, spo0E, eag" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1342856..1342874 /Source="Nicolas_upshift_promotors" /id="U1105" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=237 /SigmaFactorBS="tcattgggcatacctcctgcctggcggcgTGTTTAAgatatt cttcacctGGGTATTGTTCTTCTAATCctatcaatatatctattatacctgaaaaatt a" /listShort="S489, S490, spo0E, eag" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1342866 /Source="Nicolas_upshifts" /id="U1105" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=237 /SigmaFactorBS="tcattgggcatacctcctgcctggcggcgTGTTTAAgatatt cttcacctGGGTATTGTTCTTCTAATCctatcaatatatctattatacctgaaaaatt a" /listShort="S489, S490, spo0E, eag" /GFF_Attribute="listLong" /label="upshifts" S_feature 1342867..1342951 /Source="Nicolas_S_feature" /locus_tag="new_1430539_1430623" /HighExp="Etha, Gly, BC, Salt, Sw, B60, LoTm, M9-stat, LPhT, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S489" promotor_-10 complement(1342881..1342900) /Source="Nicolas_upshift_promotors" /id="U1106" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.682317682317682" /psig="0.999000999001" /xcortree=1602 /SigmaFactorBS="tgcattattacagattatactttatttgtaaacatattttCA TTaaataagttaatttTTCAGGTATAATAGATATATtgataggattagaagaacaata c" /listShort="S488, ykvA, S487" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1342898) /Source="Nicolas_upshifts" /id="U1106" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.682317682317682" /psig="0.999000999001" /xcortree=1602 /SigmaFactorBS="tgcattattacagattatactttatttgtaaacatattttCA TTaaataagttaatttTTCAGGTATAATAGATATATtgataggattagaagaacaata c" /listShort="S488, ykvA, S487" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1342915..1342918) /Source="Nicolas_upshift_promotors" /id="U1106" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.682317682317682" /psig="0.999000999001" /xcortree=1602 /SigmaFactorBS="tgcattattacagattatactttatttgtaaacatattttCA TTaaataagttaatttTTCAGGTATAATAGATATATtgataggattagaagaacaata c" /listShort="S488, ykvA, S487" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1342925..1342932 /Source="Nicolas_upshift_promotors" /id="U1107" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2934 /SigmaFactorBS="tacctgaaaaattaacttatttaatgaaaataTGTTTACAaa taaagtataatcTGTAATAATGCACAATAACCcaatcaaacttgtttcctatttctta g" /listShort="S490, spo0E, eag" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1342947..1342966 /Source="Nicolas_upshift_promotors" /id="U1107" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2934 /SigmaFactorBS="tacctgaaaaattaacttatttaatgaaaataTGTTTACAaa taaagtataatcTGTAATAATGCACAATAACCcaatcaaacttgtttcctatttctta g" /listShort="S490, spo0E, eag" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1342953..1343011 /Source="Nicolas_S_feature" /locus_tag="new_1430625_1430683" /HighExp="Etha, Gly, Sw, BC, LoTm, B36, T3.30H, Salt, T5.0H, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S490" upshifts 1342953 /Source="Nicolas_upshifts" /id="U1107" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2934 /SigmaFactorBS="tacctgaaaaattaacttatttaatgaaaataTGTTTACAaa taaagtataatcTGTAATAATGCACAATAACCcaatcaaacttgtttcctatttctta g" /listShort="S490, spo0E, eag" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(1343009) /Source="Nicolas_upshifts" /id="D751" /incds=0 /nref=3 /ntot=61 /MaxReadThrough="0.87927" /MaxDrop="3.53961" /score="18.5455371" /energy="-11.3" /TU="NA" /idTUdmin="U1106" /TUdmin="-682" /isTUend="FALSE" /label="downshifts" CDS 1343012..1343269 /gene="spo0E" /locus_tag="BSU_13640" /old_locus_tag="BSU13640" /function="16.13: Shape" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15057450, 15916600, 17001075, 19332814, 22524514" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15057450, 15916600, 17001075, 19332814, 22524514; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="negative regulatory phosphatase acting on Spo0A-P (sporulation)" /protein_id="NP_389247.1" /db_xref="EnsemblGenomes-Gn:BSU13640" /db_xref="EnsemblGenomes-Tr:CAB13237" /db_xref="GOA:P05043" /db_xref="InterPro:IPR018540" /db_xref="InterPro:IPR037208" /db_xref="SubtiList:BG10769" /db_xref="UniProtKB/Swiss-Prot:P05043" /translation="MGGSSEQERLLVSIDEKRKLMIDAARKQGFTGHDTIRHSQELDC LINEYHQLMQENEHSQGIQGLVKKLGLWPRRDVMPAYDANK*" /label="spo0E CDS" gene 1343012..1343269 /gene="spo0E" /locus_tag="BSU_13640" /old_locus_tag="BSU13640" /label="spo0E gene" downshifts 1343263 /Source="Nicolas_upshifts" /id="D752" /incds=0 /nref=7 /ntot=169 /MaxReadThrough="4.39402" /MaxDrop="3.59614" /score="0.224700481" /energy="-5.9" /TU="U1105,U1107" /idTUdmin="U1105" /TUdmin="-440" /isTUend="FALSE" /label="downshifts" CDS 1343355..1343786 /gene="eag" /locus_tag="BSU_13650" /old_locus_tag="BSU13650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative small membrane protein" /protein_id="NP_389248.1" /db_xref="EnsemblGenomes-Gn:BSU13650" /db_xref="EnsemblGenomes-Tr:CAB13238" /db_xref="GOA:P06630" /db_xref="SubtiList:BG10770" /db_xref="UniProtKB/Swiss-Prot:P06630" /translation="MKELAILITEMVNQFHDAFISLCGIFGIHLTDKEMHFWVIGIFG IFFFGVTHAVFTWLSKWSMTALSFIYTVTVIIVIVFAIEIQQKVTGRGNMEFLDATEG IKGFLVFFMFFLLLKMLLRFIKILFSGRPASKSNGNARSRR*" /label="eag CDS" gene 1343355..1343786 /gene="eag" /locus_tag="BSU_13650" /old_locus_tag="BSU13650" /label="eag gene" CDS complement(1343814..1345334) /gene="kinD" /locus_tag="BSU_13660" /old_locus_tag="BSU13660" /EC_number="2.7.13.3" /function="16.13: Shape" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11069677, 11673427, 16166384, 10411754, 21622736, 22074846, 22716461, 23569226" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11069677, 11673427, 16166384, 10411754, 21622736, 22074846, 22716461, 23569226; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="histidine kinase phosphorylating Spo0A" /protein_id="NP_389249.1" /db_xref="EnsemblGenomes-Gn:BSU13660" /db_xref="EnsemblGenomes-Tr:CAB13239" /db_xref="GOA:O31671" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR033479" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="PDB:4JGO" /db_xref="PDB:4JGP" /db_xref="PDB:4JGQ" /db_xref="PDB:4JGR" /db_xref="SubtiList:BG13309" /db_xref="UniProtKB/Swiss-Prot:O31671" /translation="MLERCKLKILKGACGRVKLYIILVVIPAIVISFFVYEKEKDTIA AEHKQEASVLLNLHRNKINYLIGETMARMTSLSIAIDRPVDIKKMQSILEKTFDSEPR FSGLYFLNAKGDVTASTTELKTKVNLADRSFFIKAKETKKTVISDSYSSRITGQPIFT ICVPVLDSKRNVTDYLVAAIQIDYLKNLINLLSPDVYIEVVNQDGKMIFASGQASHAE DQKPVSGYLDDISWNMKVYPNPVTIEELSKSLVLPLSCIIVLLNILFILVLYYLLKRQ TQLERSENEAQKLELIGTLAASTAHEIRNPLTGISGFIQLLQKKYKGEEDQLYFSIIE QEIKRINQIVSEFLVLGKPTAEKWELNSLQDIIGEIMPIIYSEGNLYNVEVELQYLTE QPLLVKCTKDHIKQVILNVAKNGLESMPEGGKLTISLGALDKKAIIKVVDNGEGISQE MLDHIFLPFVTSKEKGTGLGLVVCKRIVLMYGGSIHIESEVRRGTEVTITLPVSAS*" /label="kinD CDS" gene complement(1343814..1345334) /gene="kinD" /locus_tag="BSU_13660" /old_locus_tag="BSU13660" /label="kinD gene" downshifts complement(1343826) /Source="Nicolas_upshifts" /id="D753" /incds=0 /nref=106 /ntot=227 /MaxReadThrough="0.62895" /MaxDrop="5.24795" /score="18.5455371" /energy="-11.3" /TU="NA" /idTUdmin="U1109" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" promotor_-35 1344535..1344541 /Source="Nicolas_upshift_promotors" /id="U1108" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=948 /SigmaFactorBS="ctgggtctgccgcttcagcaaataatacagcacgAGAATAAa aaggatattcagCAGAACAATAATacatgaaagcggaagcacaaggcttttcgacagt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1344555..1344566 /Source="Nicolas_upshift_promotors" /id="U1108" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=948 /SigmaFactorBS="ctgggtctgccgcttcagcaaataatacagcacgAGAATAAa aaggatattcagCAGAACAATAATacatgaaagcggaagcacaaggcttttcgacagt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1344561 /Source="Nicolas_upshifts" /id="U1108" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=948 /SigmaFactorBS="ctgggtctgccgcttcagcaaataatacagcacgAGAATAAa aaggatattcagCAGAACAATAATacatgaaagcggaagcacaaggcttttcgacagt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(1345342..1345361) /Source="Nicolas_upshift_promotors" /id="U1109" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=2145 /SigmaFactorBS="aagcttgccaacatctttttctaatttttttggttatttttt cttattaaagaagaagaaacAATGATATAATACCTCTAATcaggtgtatgttggagcg a" /listShort="kinD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1345363) /Source="Nicolas_upshifts" /id="U1109" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=2145 /SigmaFactorBS="aagcttgccaacatctttttctaatttttttggttatttttt cttattaaagaagaagaaacAATGATATAATACCTCTAATcaggtgtatgttggagcg a" /listShort="kinD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1345461..1345468 /Source="Nicolas_upshift_promotors" /id="U1110" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2454 /SigmaFactorBS="cattttaaaaaagaagagaaatattggaaagattttTATTGA CAttttggtctttgttTATTAATGTTTCTCTGTAACggtttctaaaaggatgattgag a" /listShort="mhqR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1345483..1345502 /Source="Nicolas_upshift_promotors" /id="U1110" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2454 /SigmaFactorBS="cattttaaaaaagaagagaaatattggaaagattttTATTGA CAttttggtctttgttTATTAATGTTTCTCTGTAACggtttctaaaaggatgattgag a" /listShort="mhqR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1345485 /Source="Nicolas_upshifts" /id="U1110" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2454 /SigmaFactorBS="cattttaaaaaagaagagaaatattggaaagattttTATTGA CAttttggtctttgttTATTAATGTTTCTCTGTAACggtttctaaaaggatgattgag a" /listShort="mhqR" /GFF_Attribute="listLong" /label="upshifts" CDS 1345527..1345964 /gene="mhqR" /locus_tag="BSU_13670" /old_locus_tag="BSU13670" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17725564, 17962296, 18282125" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17725564, 17962296, 18282125; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (MarR family)" /protein_id="NP_389250.1" /db_xref="EnsemblGenomes-Gn:BSU13670" /db_xref="EnsemblGenomes-Tr:CAB13240" /db_xref="GOA:O31672" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13310" /db_xref="UniProtKB/Swiss-Prot:O31672" /translation="MTEKSLKLFIVLSRAYRSINDHMNKHIHKHGLNPTEFAVLELLY HKGDQPLQQIGDKILLASGSITYVVDKLEQKELLIRKASPTDRRVTFAQITEKGIGLL NDIFPDHAAEIDEMISVLSEEEVEMCTEMLKRVGLNAKQFHNK*" /label="mhqR CDS" gene 1345527..1345964 /gene="mhqR" /locus_tag="BSU_13670" /old_locus_tag="BSU13670" /label="mhqR gene" downshifts 1345947 /Source="Nicolas_upshifts" /id="D754" /incds=0 /nref=210 /ntot=257 /MaxReadThrough="1.20686" /MaxDrop="5.47215" /score="1.59181784" /energy="-8.9" /TU="U1110" /idTUdmin="U1110" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(1346004..1346789) /gene="motB" /locus_tag="BSU_13680" /old_locus_tag="BSU13680" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:16095621, 18566286, 24296669, 24771657, 25273986" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16095621, 18566286, 24296669, 24771657, 25273986; Product type f: factor" /codon_start=1 /transl_table=11 /product="motility protein B; MotB component of the H+-coupled stator flagellum complex" /protein_id="NP_389251.1" /db_xref="EnsemblGenomes-Gn:BSU13680" /db_xref="EnsemblGenomes-Tr:CAB13241" /db_xref="GOA:P28612" /db_xref="InterPro:IPR006665" /db_xref="InterPro:IPR025713" /db_xref="InterPro:IPR036737" /db_xref="SubtiList:BG10689" /db_xref="UniProtKB/Swiss-Prot:P28612" /translation="MARKKKKKHEDEHVDESWLVPYADILTLLLALFIVLYASSSIDA AKFQMLSKSFNEVFTGGTGVLDYSSVTPPENESDGIDEVKKEKEEKEKNKKEKEKAAD QEELENVKSQVEKFIKDKKLEHQLETKMTSEGLLITIKDSIFFDSGKATIRKEDVPLA KEISNLLVINPPRNIIISGHTDNMPIKNSEFQSNWHLSVMRAVNFMGLLIENPKLDAK VFSAKGYGEYKPVASNKTAEGRSKNRRVEVLILPRGAAETNEK*" /label="motB CDS" gene complement(1346004..1346789) /gene="motB" /locus_tag="BSU_13680" /old_locus_tag="BSU13680" /label="motB gene" downshifts complement(1346023) /Source="Nicolas_upshifts" /id="D755" /incds=0 /nref=224 /ntot=246 /MaxReadThrough="3.05351" /MaxDrop="6.69306" /score="21.3673767" /energy="-12.4" /TU="U1111" /idTUdmin="U1111" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" downshifts complement(1346485) /Source="Nicolas_upshifts" /id="D756" /incds=1 /nref=1 /ntot=19 /MaxReadThrough="8.03566" /MaxDrop="4.69358" /score="21.3673767" /energy="-12.4" /TU="U1111" /idTUdmin="U1111" /TUdmin="-550" /isTUend="FALSE" /label="downshifts" CDS complement(1346761..1347573) /gene="motA" /locus_tag="BSU_13690" /old_locus_tag="BSU13690" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:16095621, 18566286, 24296669, 24771657, 25273986" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16095621, 18566286, 24296669, 24771657, 25273986; Product type f: factor" /codon_start=1 /transl_table=11 /product="motility protein A; MotA component of the H+-coupled stator flagellum complex" /protein_id="NP_389252.1" /db_xref="EnsemblGenomes-Gn:BSU13690" /db_xref="EnsemblGenomes-Tr:CAB13242" /db_xref="GOA:P28611" /db_xref="InterPro:IPR000540" /db_xref="InterPro:IPR002898" /db_xref="SubtiList:BG10688" /db_xref="UniProtKB/Swiss-Prot:P28611" /translation="MDKTSLIGIILAFVALSVGMVLKGVSFSALANPAAILIIIAGTI SAVVIAFPTKEIKKVPTLFRVLFKENKQLTIEELIPMFSEWAQLARREGLLALEASIE DVDDAFLKNGLSMAVDGQSAEFIRDIMTEEVEAMEDRHQAGAAIFTQAGTYAPTLGVL GAVIGLIAALSHMDNTDELGHAISAAFVATLLGIFTGYVLWHPFANKLKRKSKQEVKL REVMIEGVLSVLEGQAPKVIEQKLLMYLPAKDRLKFAEQGEAQNGEKKEEEA*" /label="motA CDS" gene complement(1346761..1347573) /gene="motA" /locus_tag="BSU_13690" /old_locus_tag="BSU13690" /label="motA gene" promotor_-10 complement(1347604..1347622) /Source="Nicolas_upshift_promotors" /id="U1111" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2801 /SigmaFactorBS="tcttccttgaatatttcatgaacaaattcacaatgtcCCTAA AGTtccgggcaccaaaACCGATATTAACCATAGACaagctagtaaaaaaggatttggt g" /listShort="motA, motB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1347620) /Source="Nicolas_upshifts" /id="U1111" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2801 /SigmaFactorBS="tcttccttgaatatttcatgaacaaattcacaatgtcCCTAA AGTtccgggcaccaaaACCGATATTAACCATAGACaagctagtaaaaaaggatttggt g" /listShort="motA, motB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1347636..1347643) /Source="Nicolas_upshift_promotors" /id="U1111" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2801 /SigmaFactorBS="tcttccttgaatatttcatgaacaaattcacaatgtcCCTAA AGTtccgggcaccaaaACCGATATTAACCATAGACaagctagtaaaaaaggatttggt g" /listShort="motA, motB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(1347711..1347933) /Source="Nicolas_S_feature" /locus_tag="new_1435383_1435605_c" /HighExp="Diami, dia15, dia5, Heat, Etha, LPhT, H2O2, C30, G135, S7" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.93062599999999995" /TUshortSig="SigA" /TUshortPSig="0.671" /TUlongSig="NA" /TUlongPSig="NA" /label="S491" downshifts complement(1347743) /Source="Nicolas_upshifts" /id="D757" /incds=0 /nref=5 /ntot=12 /MaxReadThrough="0.48394" /MaxDrop="4.60081" /score="30.9355071" /energy="-15.4" /TU="NA" /idTUdmin="U1112" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS complement(1347956..1350055) /gene="clpE" /locus_tag="BSU_13700" /old_locus_tag="BSU13700" /function="16.3: Control" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9987115, 10320580, 11069659, 14679237, 16788169, 16899079, 18689473, 19226326, 21208299, 28333276" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9987115, 10320580, 11069659, 14679237, 16788169, 16899079, 18689473, 19226326, 21208299, 28333276; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent Clp protease (class III stress gene)" /protein_id="NP_389253.1" /db_xref="EnsemblGenomes-Gn:BSU13700" /db_xref="EnsemblGenomes-Tr:CAB13243" /db_xref="GOA:O31673" /db_xref="InterPro:IPR001270" /db_xref="InterPro:IPR001943" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR003959" /db_xref="InterPro:IPR018368" /db_xref="InterPro:IPR019489" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR028299" /db_xref="SubtiList:BG12578" /db_xref="UniProtKB/Swiss-Prot:O31673" /translation="MRCQHCHQNEATIRLNMQINSVHKQMVLCETCYNELTRKPSMSM GPQSFGFPFEQAFQPKEQSAAKQSEKKGLLDELAQNITNGAKAGLIDPVIGRDDEVAR VIEILNRRNKNNPVLIGEPGVGKTAIAEGLALKIAEGDVPNKLKNKELYLLDVASLVA NTGIRGQFEERMKQLITELKERKNVILFIDEIHLLVGAGSAEGSMDAGNILKPALARG ELQVIGATTLKEYRQIEKDAALERRFQPVMVQEPSIEQAILILQGIKDKYEAYHGVTF SDEAIKACVTLSSRYIQDRHLPDKAIDLLDEAGSKANLLIDELNDEDAAERLTAIEAE KTKALEEENYELAAKLRDEELALEKKLNSSSAHTAVTVEAEHIQEIVEQKTGIPVGKL QADEQTKMKELEAKLHERVIGQEAAVQKVAKAVRRSRAGLKSKNRPVGSFLFVGPTGV GKTELSKTLADELFGTKDAIIRLDMSEYMEKHAVSKIIGSPPGYVGHEEAGQLTEKVR RNPYSIVLLDEIEKAHPDVQHMFLQIMEDGRLTDSQGRTVSFKDTVIIMTSNAGAGEK QTKVGFQSDDSVIEEQTLIDSLSMFFKPEFLNRFDSIIEFRSLEKEHLVKIVSLLLGE LEETLAERGISLNVTDEAKEKIAELGYHPSFGARPLRRTIQEWVEDEMTDLLLDNGEI TSFHVILEDDKIKVRAK*" /label="clpE CDS" gene complement(1347956..1350055) /gene="clpE" /locus_tag="BSU_13700" /old_locus_tag="BSU13700" /label="clpE gene" downshifts complement(1347978) /Source="Nicolas_upshifts" /id="D758" /incds=0 /nref=27 /ntot=132 /MaxReadThrough="4.1802" /MaxDrop="6.07862" /score="41.2563375" /energy="-13.6" /TU="U1112" /idTUdmin="U1112" /TUdmin="-239" /isTUend="FALSE" /label="downshifts" S_feature complement(1350056..1350306) /Source="Nicolas_S_feature" /locus_tag="new_1437728_1437978_c" /HighExp="dia5, Heat, Diami, LPhT, dia15, H2O2, HiTm, S2, Cold, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.671" /TUlongSig="NA" /TUlongPSig="NA" /label="S492" promotor_no_box complement(1350266..1350366) /Source="Nicolas_upshift_promotors" /id="U1112" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.437562437562438" /psig="0.671328671328671" /xcortree=2025 /SigmaFactorBS="atgagacaagttccttgaaaagacgaagaaaacatgttttac tttgtaacaaatcaaaaatttttgtgcataagacttgaaagtcaaagatagtcagagt a" /listShort="S492, clpE, S491" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1350306) /Source="Nicolas_upshifts" /id="U1112" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.437562437562438" /psig="0.671328671328671" /xcortree=2025 /SigmaFactorBS="atgagacaagttccttgaaaagacgaagaaaacatgttttac tttgtaacaaatcaaaaatttttgtgcataagacttgaaagtcaaagatagtcagagt a" /listShort="S492, clpE, S491" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1350342..1350347 /Source="Nicolas_upshift_promotors" /id="U1113" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=984 /SigmaFactorBS="tgcacaaaaatttttgatttgttacaaagtaaaacatgtttt cttCGTCTTttcaaggaacttgtcTCATAGGTTATAAAAAGGCatatatggacaaaac t" /listShort="ykvI, S493" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1350357 /Source="Nicolas_upshifts" /id="U1113" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=984 /SigmaFactorBS="tgcacaaaaatttttgatttgttacaaagtaaaacatgtttt cttCGTCTTttcaaggaacttgtcTCATAGGTTATAAAAAGGCatatatggacaaaac t" /listShort="ykvI, S493" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1350363..1350381 /Source="Nicolas_upshift_promotors" /id="U1113" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=984 /SigmaFactorBS="tgcacaaaaatttttgatttgttacaaagtaaaacatgtttt cttCGTCTTttcaaggaacttgtcTCATAGGTTATAAAAAGGCatatatggacaaaac t" /listShort="ykvI, S493" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1350420..1351463 /gene="ykvI" /locus_tag="BSU_13710" /old_locus_tag="BSU13710" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15383836, 15849754, 16850406, 26735940; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_389254.1" /db_xref="EnsemblGenomes-Gn:BSU13710" /db_xref="EnsemblGenomes-Tr:CAB13244" /db_xref="GOA:O31674" /db_xref="SubtiList:BG13311" /db_xref="UniProtKB/Swiss-Prot:O31674" /translation="MEQSKGSASQLAFVYVGTVVGAGFATGREIVEFFLKFGWFGFFG ILVSGGMFTLLGAKLMIISKRINAKSYQEMNIFLFGATAGRIINVFMLFVLLGVTSVM LSGAGALFEEQLGMSAQIGMLITIGLSLIVMTRGVKGIFGVNVFVVPLLIIFSMIVVA DSFIFSESRNAAQWVWPHRWDWLLSAVSYGALNLSLAQAVLVPLANEMSSEKVIKKGA LIGGTMLTIVLSASFLSLSTLPDVFLYDIPMAQVVYLFARSVHLIYLLIIFGEVFTSV IGNLYGLEKQVQSFLPVKSKYIFAAIMITAYITSQIGYGRLISTIYPLFGYVSLAFIG ALLCKKAPRRRSL*" /label="ykvI CDS" gene 1350420..1351463 /gene="ykvI" /locus_tag="BSU_13710" /old_locus_tag="BSU13710" /label="ykvI gene" S_feature 1351464..1351555 /Source="Nicolas_S_feature" /locus_tag="new_1439136_1439227" /HighExp="S3, LoTm, S4, S5, BT, M9-stat, S6, T5.0H, T4.0H, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S493" promotor_-35 1351532..1351536 /Source="Nicolas_upshift_promotors" /id="U1114" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.906093906093906" /psig=1 /xcortree=2483 /SigmaFactorBS="cgataattgatctaggaaccggggactgactttttTATTGtc aagaaaaacatcatTATGGTAAGATAGCAGAAGTgaaaaaattgaagaaaatccgtgc g" /listShort="NA, S494, queC, queD, queE, queF, S495" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1351553..1351572 /Source="Nicolas_upshift_promotors" /id="U1114" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.906093906093906" /psig=1 /xcortree=2483 /SigmaFactorBS="cgataattgatctaggaaccggggactgactttttTATTGtc aagaaaaacatcatTATGGTAAGATAGCAGAAGTgaaaaaattgaagaaaatccgtgc g" /listShort="NA, S494, queC, queD, queE, queF, S495" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1351557 /Source="Nicolas_upshifts" /id="U1114" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.906093906093906" /psig=1 /xcortree=2483 /SigmaFactorBS="cgataattgatctaggaaccggggactgactttttTATTGtc aagaaaaacatcatTATGGTAAGATAGCAGAAGTgaaaaaattgaagaaaatccgtgc g" /listShort="NA, S494, queC, queD, queE, queF, S495" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 1351602..1351646 /gene="qswA" /locus_tag="BSU_misc_RNA_22" /product="preQ1 riboswitch" /experiment="publication(s) with functional evidences, PMID:17384645, 19234468, 19285444, 20534493, 21410253, 21592962, 24798077, 27484311" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17384645, 19234468, 19285444, 20534493, 21410253, 21592962, 24798077, 27484311; Product type n: RNA" /function="16.3: Control" /label="qswA RNA" gene 1351602..1351646 /gene="qswA" /locus_tag="BSU_misc_RNA_22" /label="qswA gene" downshifts 1351623 /Source="Nicolas_upshifts" /id="D759" /incds=0 /nref=11 /ntot=17 /MaxReadThrough="7.29177" /MaxDrop="4.09959" /score="21.1398563" /energy="-9.5" /TU="U1114" /idTUdmin="U1113" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 1351668..1351775 /Source="Nicolas_S_feature" /locus_tag="new_1439340_1439447" /HighExp="Paraq, ferm, G180, LBGstat, Diami, H2O2, LPhT, Oxctl, G135, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S494" CDS 1351776..1352435 /gene="queC" /locus_tag="BSU_13720" /old_locus_tag="BSU13720" /EC_number="6.3.4.20" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:14660578, 16199558, 17384645, 18491386, 19354300" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14660578, 16199558, 17384645, 18491386, 19354300; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pre-queuosine 0 synthase" /protein_id="NP_389255.1" /db_xref="EnsemblGenomes-Gn:BSU13720" /db_xref="EnsemblGenomes-Tr:CAB13245" /db_xref="GOA:O31675" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR018317" /db_xref="PDB:3BL5" /db_xref="SubtiList:BG13312" /db_xref="UniProtKB/Swiss-Prot:O31675" /translation="MKKEKAIVVFSGGQDSTTCLLWALKEFEEVETVTFHYNQRHSQE VEVAKSIAEKLGVKNHLLDMSLLNQLAPNALTRNDIEIEVKDGELPSTFVPGRNLVFL SFASILAYQIGARHIITGVCETDFSGYPDCRDEFVKSCNVTVNLAMEKPFVIHTPLMW LNKAETWKLADELGALDFVKNNTLTCYNGIIADGCGECPACHLRSKGYEEYMVMKGER A*" /label="queC CDS" gene 1351776..1352435 /gene="queC" /locus_tag="BSU_13720" /old_locus_tag="BSU13720" /label="queC gene" CDS 1352428..1352877 /gene="queD" /locus_tag="BSU_13730" /old_locus_tag="BSU13730" /EC_number="4.1.2.50" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12123838, 14660578, 16199558, 18259064, 19231875" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12123838, 14660578, 16199558, 18259064, 19231875; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="6-carboxy-5,6,7,8-tetrahydropterin synthase; queuosine biosynthesis" /protein_id="NP_389256.1" /db_xref="EnsemblGenomes-Gn:BSU13730" /db_xref="EnsemblGenomes-Tr:CAB13246" /db_xref="GOA:O31676" /db_xref="InterPro:IPR007115" /db_xref="SubtiList:BG13313" /db_xref="UniProtKB/Swiss-Prot:O31676" /translation="MHKLLSQIYPQAQHPYSFELNKDMHISAAHFIPRESAGACSRVH GHTYTVNITVAGDELDDSGFLVNFSVLKKLVHGNYDHTLLNDHEDFSQDDRYSLPTTE VVAKTIYDNVQAYLDTLENKPTCVQVFVRETPTSYCVYRPKKGGLNG*" /label="queD CDS" gene 1352428..1352877 /gene="queD" /locus_tag="BSU_13730" /old_locus_tag="BSU13730" /label="queD gene" CDS 1352870..1353601 /gene="queE" /locus_tag="BSU_13740" /old_locus_tag="BSU13740" /EC_number="4.3.99.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12123838, 14660578, 16199558, 19354300, 23194065" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12123838, 14660578, 16199558, 19354300, 23194065; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="7-carboxy-7-deazaguanine synthase" /protein_id="NP_389257.1" /db_xref="EnsemblGenomes-Gn:BSU13740" /db_xref="EnsemblGenomes-Tr:CAB13247" /db_xref="GOA:O31677" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR017742" /db_xref="InterPro:IPR023404" /db_xref="InterPro:IPR024924" /db_xref="PDB:5TGS" /db_xref="PDB:5TH5" /db_xref="SubtiList:BG13314" /db_xref="UniProtKB/Swiss-Prot:O31677" /translation="MAKGIPVLEIFGPTIQGEGMVIGQKTMFVRTAGCDYSCSWCDSA FTWDGSAKKDIRWMTAEEIFAELKDIGGDAFSHVTISGGNPALLKQLDAFIELLKENN IRAALETQGTVYQDWFTLIDDLTISPKPPSSKMVTNFQKLDHILTSLQENDRQHAVSL KVVIFNDEDLEFAKTVHKRYPGIPFYLQVGNDDVHTTDDQSLIAHLLGKYEALVDKVA VDAELNLVRVLPQLHTLLWGNKRGV*" /label="queE CDS" gene 1352870..1353601 /gene="queE" /locus_tag="BSU_13740" /old_locus_tag="BSU13740" /label="queE gene" CDS 1353619..1354116 /gene="queF" /locus_tag="BSU_13750" /old_locus_tag="BSU13750" /EC_number="1.7.1.13" /function="10.3: tRNA and rRNA base modification" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12123838, 14660578, 16199558, 17929836, 22938038, 23410922, 28300774" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12123838, 14660578, 16199558, 17929836, 22938038, 23410922, 28300774; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADPH-dependent 7-cyano-7-deazaguanine reductase" /protein_id="NP_389258.1" /db_xref="EnsemblGenomes-Gn:BSU13750" /db_xref="EnsemblGenomes-Tr:CAB13248" /db_xref="GOA:O31678" /db_xref="InterPro:IPR016856" /db_xref="InterPro:IPR029500" /db_xref="PDB:4F8B" /db_xref="PDB:4FGC" /db_xref="PDB:5UDG" /db_xref="SubtiList:BG13315" /db_xref="UniProtKB/Swiss-Prot:O31678" /translation="MTTRKESELEGVTLLGNQGTNYLFEYAPDVLESFPNKHVNRDYF VKFNCPEFTSLCPKTGQPDFATIYISYIPDEKMVESKSLKLYLFSFRNHGDFHEDCMN IIMNDLIELMDPRYIEVWGKFTPRGGISIDPYTNYGKPGTKYEKMAEYRMMNHDLYPE TIDNR*" /label="queF CDS" gene 1353619..1354116 /gene="queF" /locus_tag="BSU_13750" /old_locus_tag="BSU13750" /label="queF gene" S_feature 1354117..1354393 /Source="Nicolas_S_feature" /locus_tag="new_1441789_1442065" /HighExp="Paraq, ferm, LPhT, C30, G135, G180, LBGstat, Oxctl, G150, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S495" downshifts 1354351 /Source="Nicolas_upshifts" /id="D760" /incds=0 /nref=200 /ntot=247 /MaxReadThrough="1.17154" /MaxDrop="6.60953" /score="11.1883045" /energy="-7.8" /TU="NA" /idTUdmin="U1114" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1354361) /Source="Nicolas_upshifts" /id="D761" /incds=0 /nref=1 /ntot=4 /MaxReadThrough="1.54726" /MaxDrop="2.16508" /score="6.24357423" /energy="-7.6" /TU="NA" /idTUdmin="U1115" /TUdmin=110 /isTUend="FALSE" /label="downshifts" S_feature complement(1354430..1354674) /Source="Nicolas_S_feature" /locus_tag="new_1442102_1442346_c" /HighExp="Diami, dia5, LPhT, Etha, Salt, dia15, Heat, HiTm, C30, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.15795400000000001" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S496" downshifts complement(1354471) /Source="Nicolas_upshifts" /id="D762" /incds=0 /nref=47 /ntot=193 /MaxReadThrough="2.13712" /MaxDrop="5.08206" /score="6.24357423" /energy="-7.6" /TU="NA" /idTUdmin="U1115" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1354675..1355031) /gene="ykvN" /locus_tag="BSU_13760" /old_locus_tag="BSU13760" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16683018; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (HGT island)" /protein_id="NP_389259.1" /db_xref="EnsemblGenomes-Gn:BSU13760" /db_xref="EnsemblGenomes-Tr:CAB13249" /db_xref="GOA:O31679" /db_xref="InterPro:IPR002577" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13316" /db_xref="UniProtKB/Swiss-Prot:O31679" /translation="MKKFSCGFEVTKEVIGGKWKGLVLYFLMNGPKRTSELKRIIPNI TQKMLIQTLRELEASGLVSRKMYNQVPPKVEYSSTELGESLKPILQELCQWGGYYAEQ EYAEGEYEIVQPEQLS*" /label="ykvN CDS" gene complement(1354675..1355031) /gene="ykvN" /locus_tag="BSU_13760" /old_locus_tag="BSU13760" /label="ykvN gene" misc_feature complement(1355062..1355081) /Source="Nicolas_upshift_promotors" /id="U1115" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.727272727272727" /psig="0.997002997002997" /xcortree=1897 /SigmaFactorBS="acaacttacaagatatagtatccttcagtaagcacattatcg gaagtacccactttttTGTGATATAGTAACTAAAAAgtaataaatgtggaatggagag c" /listShort="ykvN, S496" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1355079) /Source="Nicolas_upshifts" /id="U1115" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.727272727272727" /psig="0.997002997002997" /xcortree=1897 /SigmaFactorBS="acaacttacaagatatagtatccttcagtaagcacattatcg gaagtacccactttttTGTGATATAGTAACTAAAAAgtaataaatgtggaatggagag c" /listShort="ykvN, S496" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1355116..1355134 /Source="Nicolas_upshift_promotors" /id="U1116" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.313686313686314" /psig="0.954045954045954" /xcortree=1793 /SigmaFactorBS="ctttttagttactatatcacaaaaaagtgggtacttCcgata atgtgcttactgaAGGATACTATATCTTGTAAgttgttcttcaagtacttaaaggtac t" /listShort="ykvO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1355121 /Source="Nicolas_upshifts" /id="U1116" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.313686313686314" /psig="0.954045954045954" /xcortree=1793 /SigmaFactorBS="ctttttagttactatatcacaaaaaagtgggtacttCcgata atgtgcttactgaAGGATACTATATCTTGTAAgttgttcttcaagtacttaaaggtac t" /listShort="ykvO" /GFF_Attribute="listLong" /label="upshifts" CDS 1355200..1355946 /gene="ykvO" /locus_tag="BSU_13770" /old_locus_tag="BSU13770" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16683018, 26494135; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase (HGT island)" /protein_id="NP_389260.1" /db_xref="EnsemblGenomes-Gn:BSU13770" /db_xref="EnsemblGenomes-Tr:CAB13250" /db_xref="GOA:O31680" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13317" /db_xref="UniProtKB/Swiss-Prot:O31680" /translation="MGKFEGKIALVTGGTSGIGLATAQKFVNEGAYVYITGRRQNELD KAVNQIGKNVTGVQGDISKLEDLDKLYDIIKQEKGKLDILFANAGIGNFLPLGEITEE QVDRTFDINVKGTIFTVQKALSLFPDKVGSIIVTGSTAGSIGNPAFSVYGASKAALRA LVRNWILDLKGTEIRVNVVSPGGILTPAYDELFGDALEEVLENSRNTVPAGKVGTPEE VANAVSFLASDESSYLTGVELFVDGGLAQV*" /label="ykvO CDS" gene 1355200..1355946 /gene="ykvO" /locus_tag="BSU_13770" /old_locus_tag="BSU13770" /label="ykvO gene" downshifts 1356001 /Source="Nicolas_upshifts" /id="D763" /incds=0 /nref=19 /ntot=146 /MaxReadThrough="0.723690000000001" /MaxDrop="4.37163" /score="1.34631843" /energy="-9.1" /TU="NA" /idTUdmin="U1116" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1356349..1356357 /Source="Nicolas_upshift_promotors" /id="U1117" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1420 /SigmaFactorBS="tctcgtgatctcacacctgaacgttttttatagaCTAGTACC GcgacaagttatatTACATATACATACCAATAAAgtagacattaaaaagtgaaagaga g" /listShort="ykvP, ykzQ, S497, ykvQ, ykzR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1356371..1356390 /Source="Nicolas_upshift_promotors" /id="U1117" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1420 /SigmaFactorBS="tctcgtgatctcacacctgaacgttttttatagaCTAGTACC GcgacaagttatatTACATATACATACCAATAAAgtagacattaaaaagtgaaagaga g" /listShort="ykvP, ykzQ, S497, ykvQ, ykzR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1356375 /Source="Nicolas_upshifts" /id="U1117" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1420 /SigmaFactorBS="tctcgtgatctcacacctgaacgttttttatagaCTAGTACC GcgacaagttatatTACATATACATACCAATAAAgtagacattaaaaagtgaaagaga g" /listShort="ykvP, ykzQ, S497, ykvQ, ykzR" /GFF_Attribute="listLong" /label="upshifts" CDS 1356427..1357626 /gene="ykvP" /locus_tag="BSU_13780" /old_locus_tag="BSU13780" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11011148, 16683018" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11011148, 16683018; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore protein (HGT island)" /protein_id="NP_389261.1" /db_xref="EnsemblGenomes-Gn:BSU13780" /db_xref="EnsemblGenomes-Tr:CAB13251" /db_xref="GOA:O31681" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG13318" /db_xref="UniProtKB/Swiss-Prot:O31681" /translation="MKILFLESHPMWLYGLPNGFREAGHTVMISGPVSRENITEMIDE FKPDLIVSMGWTPEHSREKQAWIRNATKKVNIPLVYWATEDPLHTQNFTIPLIKKMKP DFVFTVTPSLCKTYESMGIKAAHLDFAFHESIHHQIKPLAKYSCDIAVVANAYPNFLE EHPEVFRSSSLKTLIRPLIRKGIRIDFWGRNWEKMSKYIGREIPRNWIHGYLDYTEAY KVYSSAKIIIGLQNCESQLTQRTYEILGSGGFLLTSDTPAVRGKFKPGRDLIVSSSPK ETLEKVKYYLNHDSERKKIQINGKKAVKNDSYRHRAERMLEVLKSRGIIRNLGETIHY VDVLKEKYVIHHVTPGETLSIIASKYNVSLQQLMELNHFKSDQIYAGQIIKIREKLFR NINNKLF*" /label="ykvP CDS" gene 1356427..1357626 /gene="ykvP" /locus_tag="BSU_13780" /old_locus_tag="BSU13780" /label="ykvP gene" promotor_-35 1356509..1356515 /Source="Nicolas_upshift_promotors" /id="U1118" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=152 /SigmaFactorBS="cgaatgggtttagggaagcaggacataccgtaaTGATTTCcg gtcctgtaagtcGGGAAAATATAACTGAAATgatagacgaatttaaaccagatttaat a" /listShort="ykzQ, S497, ykvQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1356530..1356548 /Source="Nicolas_upshift_promotors" /id="U1118" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=152 /SigmaFactorBS="cgaatgggtttagggaagcaggacataccgtaaTGATTTCcg gtcctgtaagtcGGGAAAATATAACTGAAATgatagacgaatttaaaccagatttaat a" /listShort="ykzQ, S497, ykvQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1356536 /Source="Nicolas_upshifts" /id="U1118" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=152 /SigmaFactorBS="cgaatgggtttagggaagcaggacataccgtaaTGATTTCcg gtcctgtaagtcGGGAAAATATAACTGAAATgatagacgaatttaaaccagatttaat a" /listShort="ykzQ, S497, ykvQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1357595..1357597 /Source="Nicolas_upshift_promotors" /id="U1119" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.346653346653347" /psig="0.602397602397602" /xcortree=2158 /SigmaFactorBS="acaaatcattaagattagagagaaacTGTttagaaatattaa taacaaATTATTCTAAAGGAGAGTAatatgaatgaaggggaaaatacctaaaataaga a" /listShort="ykzQ, S497, ykvQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1357617..1357635 /Source="Nicolas_upshift_promotors" /id="U1119" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.346653346653347" /psig="0.602397602397602" /xcortree=2158 /SigmaFactorBS="acaaatcattaagattagagagaaacTGTttagaaatattaa taacaaATTATTCTAAAGGAGAGTAatatgaatgaaggggaaaatacctaaaataaga a" /listShort="ykzQ, S497, ykvQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1357629 /Source="Nicolas_upshifts" /id="U1119" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.346653346653347" /psig="0.602397602397602" /xcortree=2158 /SigmaFactorBS="acaaatcattaagattagagagaaacTGTttagaaatattaa taacaaATTATTCTAAAGGAGAGTAatatgaatgaaggggaaaatacctaaaataaga a" /listShort="ykzQ, S497, ykvQ" /GFF_Attribute="listLong" /label="upshifts" CDS 1357642..1357869 /gene="ykzQ" /locus_tag="BSU_13789" /old_locus_tag="BSU13789" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative peptidoglycan binding protein" /protein_id="YP_003097719.1" /db_xref="EnsemblGenomes-Gn:BSU13789" /db_xref="EnsemblGenomes-Tr:CAX52610" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="UniProtKB/Swiss-Prot:C0H403" /translation="MKGKIPKIRNQANKVKRTPRYMEFPVTYEVYHVESGDTLWTIAK SFEIPVQQLMNLNKLSSDRIYPGQIIKIRER*" /label="ykzQ CDS" gene 1357642..1357869 /gene="ykzQ" /locus_tag="BSU_13789" /old_locus_tag="BSU13789" /label="ykzQ gene" misc_feature complement(1357719..1357738) /Source="Nicolas_upshift_promotors" /id="U1120" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.937062937062937" /psig="0.982017982017982" /xcortree=2163 /SigmaFactorBS="ggaatttcaaaggatttggcaatcgtccataatgtatcgccg gattccaCATGATATACTTCGTATGTCacgggaaattccatataacgaggcgttcttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1357727) /Source="Nicolas_upshifts" /id="U1120" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.937062937062937" /psig="0.982017982017982" /xcortree=2163 /SigmaFactorBS="ggaatttcaaaggatttggcaatcgtccataatgtatcgccg gattccaCATGATATACTTCGTATGTCacgggaaattccatataacgaggcgttcttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature 1357870..1357965 /Source="Nicolas_S_feature" /locus_tag="new_1445542_1445637" /HighExp="BT, S8, B36, S7, Etha, S6, G/S, LBGstat, Pyr, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB, SigK" /TUshortPSig="0.602, 0.999, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S497" CDS 1357966..1358664 /gene="ykvQ" /locus_tag="BSU_13790" /old_locus_tag="BSU13790" /EC_number="3.2.-.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16683018; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative sporulation-specific glycosylase (HGT island)" /db_xref="EnsemblGenomes-Gn:BSU13790" /db_xref="EnsemblGenomes-Tr:CAB13252" /db_xref="GOA:O31682" /db_xref="InterPro:IPR001223" /db_xref="InterPro:IPR011583" /db_xref="InterPro:IPR017853" /db_xref="PSEUDO:CAB13252.1" /db_xref="SubtiList:BG13319" /db_xref="UniProtKB/Swiss-Prot:O31682" /translation="MFQMSYYYSGLGWDFIQHVDQTNGVLNVVSPDFFYIRKDGSLLL RSANPDVIKALHRRKLKVVPFLSNHWDQDLGRFALMNRVLLAKQISHAIEELDLDGVN IDIENLTEKDRNLFTDFIRLVRKSIPRHKEVSVAVAANPFGWTKGWHGSYDYEYLAKY ADYLMVMAYDESRLAGPTASVGWVEKSIQYVLTQKISPQKLVLGLPFYGRCWMEGQSA SQAIPLYLVVSKKA*" /label="ykvQ CDS" gene 1357966..1358664 /gene="ykvQ" /locus_tag="BSU_13790" /old_locus_tag="BSU13790" /pseudo /label="ykvQ gene" S_feature complement(1358617..1359443) /Source="Nicolas_S_feature" /locus_tag="new_1446289_1447115_c" /HighExp="H2O2, M40t90, S8, M40t45, LPhT, Sw, Cold, LBGstat, C30, dia15" /AntisenseName="ykzR" /AntisenseCor="0.170402182980955" /AntisenseRegPval="-2.2999999999999998" /CDS_PredictionProba="0.38670900000000002" /TUshortSig="SigA" /TUshortPSig="0.986" /TUlongSig="NA" /TUlongPSig="NA" /label="S498" CDS 1358645..1358896 /gene="ykzR" /locus_tag="BSU_13799" /old_locus_tag="BSU13799" /function="16.8: Protect" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16683018; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative spore-specific glycosyl hydrolase" /db_xref="EnsemblGenomes-Gn:BSU13799" /db_xref="EnsemblGenomes-Tr:CAX52611" /db_xref="GOA:C0H404" /db_xref="InterPro:IPR017853" /db_xref="PSEUDO:CAX52611.1" /db_xref="UniProtKB/Swiss-Prot:C0H404" /translation="MLVKRHSGTIIFDTKSQSPKAIFTVNHDKKGPLPSGTYTLWFEN EQSLRAKIKLAQKYNLKGLGSWSLGQEDASVWNTVFKNI*" /label="ykzR CDS" gene 1358645..1358896 /gene="ykzR" /locus_tag="BSU_13799" /old_locus_tag="BSU13799" /pseudo /label="ykzR gene" misc_feature 1359146..1359161 /Source="Nicolas_upshift_promotors" /id="U1121" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.516483516483517" /psig="0.516483516483517" /xcortree=2456 /SigmaFactorBS="ctgcttccatgatttaatcatacacatgctacttgatAGCAG GGTTATCGCATttcattcagaattgttcaggatcgatatggaagcgcacgactaacta g" /listShort="S499" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 1359169..1359380 /Source="Nicolas_S_feature" /locus_tag="new_1446841_1447052" /HighExp="Diami, S8, dia15, G180, HPh, C30, Paraq, H2O2, Salt, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigL" /TUshortPSig="0.516" /TUlongSig="NA" /TUlongPSig="NA" /label="S499" upshifts 1359169 /Source="Nicolas_upshifts" /id="U1121" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.516483516483517" /psig="0.516483516483517" /xcortree=2456 /SigmaFactorBS="ctgcttccatgatttaatcatacacatgctacttgatAGCAG GGTTATCGCATttcattcagaattgttcaggatcgatatggaagcgcacgactaacta g" /listShort="S499" /GFF_Attribute="listLong" /label="upshifts" downshifts 1359345 /Source="Nicolas_upshifts" /id="D764" /incds=0 /nref=2 /ntot=72 /MaxReadThrough="2.59168" /MaxDrop="2.74537" /score="-4.38958816" /energy="-9" /TU="NA" /idTUdmin="U1121" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1359432..1359451) /Source="Nicolas_upshift_promotors" /id="U1122" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.879120879120879" /psig="0.986013986013986" /xcortree=1501 /SigmaFactorBS="gttcttaacggttatatgaaccaattcattcgaaaagacaCC TTTACAaacatacgttcgttaAATTATAATAAAACAGACGAgctgccatccagcatcc c" /listShort="S498" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1359454) /Source="Nicolas_upshifts" /id="U1122" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.879120879120879" /psig="0.986013986013986" /xcortree=1501 /SigmaFactorBS="gttcttaacggttatatgaaccaattcattcgaaaagacaCC TTTACAaacatacgttcgttaAATTATAATAAAACAGACGAgctgccatccagcatcc c" /listShort="S498" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1359467..1359474) /Source="Nicolas_upshift_promotors" /id="U1122" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.879120879120879" /psig="0.986013986013986" /xcortree=1501 /SigmaFactorBS="gttcttaacggttatatgaaccaattcattcgaaaagacaCC TTTACAaacatacgttcgttaAATTATAATAAAACAGACGAgctgccatccagcatcc c" /listShort="S498" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1359519..1359526 /Source="Nicolas_upshift_promotors" /id="U1123" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.8001998001998" /psig=1 /xcortree=2042 /SigmaFactorBS="cgaatgaattggttcatataaccgttaagaacagatTCATTG TAaacattcgctaaggTATGCTAAGATGCATGGACTataaaggagtgatatgaagtga a" /listShort="ykvR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1359541..1359560 /Source="Nicolas_upshift_promotors" /id="U1123" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.8001998001998" /psig=1 /xcortree=2042 /SigmaFactorBS="cgaatgaattggttcatataaccgttaagaacagatTCATTG TAaacattcgctaaggTATGCTAAGATGCATGGACTataaaggagtgatatgaagtga a" /listShort="ykvR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1359543 /Source="Nicolas_upshifts" /id="U1123" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.8001998001998" /psig=1 /xcortree=2042 /SigmaFactorBS="cgaatgaattggttcatataaccgttaagaacagatTCATTG TAaacattcgctaaggTATGCTAAGATGCATGGACTataaaggagtgatatgaagtga a" /listShort="ykvR" /GFF_Attribute="listLong" /label="upshifts" CDS 1359579..1359869 /gene="ykvR" /locus_tag="BSU_13800" /old_locus_tag="BSU13800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein (HGT island)" /protein_id="NP_389263.1" /db_xref="EnsemblGenomes-Gn:BSU13800" /db_xref="EnsemblGenomes-Tr:CAB13253" /db_xref="InterPro:IPR021596" /db_xref="InterPro:IPR023105" /db_xref="PDB:2JN9" /db_xref="SubtiList:BG13320" /db_xref="UniProtKB/Swiss-Prot:O31683" /translation="MKTLRLNNVTLEMAAYQEESEPKRKIAFTLNVTSETYHDIAVLL YEKTFNVEVPERDLAFRGEMTNYSTSLTNLYEPGAVSEFYIEITEIDKNADS*" /label="ykvR CDS" gene 1359579..1359869 /gene="ykvR" /locus_tag="BSU_13800" /old_locus_tag="BSU13800" /label="ykvR gene" S_feature complement(1359906..1359989) /Source="Nicolas_S_feature" /locus_tag="new_1447578_1447661_c" /HighExp="Etha, dia5, Salt, SMMPr, Lbtran, dia15, Heat, S4, HiOs, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S500" downshifts complement(1359949) /Source="Nicolas_upshifts" /id="D765" /incds=0 /nref=216 /ntot=257 /MaxReadThrough="2.80569" /MaxDrop="6.83857" /score="21.3524751" /energy="-9.9" /TU="U1124" /idTUdmin="U1126" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1359990..1360175) /gene="ykvS" /locus_tag="BSU_13810" /old_locus_tag="BSU13810" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (HGT island)" /protein_id="NP_389264.2" /db_xref="EnsemblGenomes-Gn:BSU13810" /db_xref="EnsemblGenomes-Tr:CAB13254" /db_xref="InterPro:IPR018690" /db_xref="SubtiList:BG13321" /db_xref="UniProtKB/Swiss-Prot:O31684" /translation="MKIAKVGNVIEFKNGLTGVVEKVNENSVIVDVTIMDNYRDLELD SLTVVNHKNYKIIRDSY*" /label="ykvS CDS" gene complement(1359990..1360175) /gene="ykvS" /locus_tag="BSU_13810" /old_locus_tag="BSU13810" /label="ykvS gene" promotor_-10 complement(1360208..1360227) /Source="Nicolas_upshift_promotors" /id="U1124" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.665334665334665" /psig="0.995004995004995" /xcortree=2222 /SigmaFactorBS="aacaattcataagggagataaaactccttatCGCTTTACttc tcaatgaaaaTACTGCAAAATACTTTCAAAaggcattattatgtttaaaggagaggaa g" /listShort="ykvS, S500" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1360219) /Source="Nicolas_upshifts" /id="U1124" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.665334665334665" /psig="0.995004995004995" /xcortree=2222 /SigmaFactorBS="aacaattcataagggagataaaactccttatCGCTTTACttc tcaatgaaaaTACTGCAAAATACTTTCAAAaggcattattatgtttaaaggagaggaa g" /listShort="ykvS, S500" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1360221..1360565) /Source="Nicolas_S_feature" /locus_tag="new_1447893_1448237_c" /HighExp="S4, S8, S6, S5, S3, T5.0H, LoTm, S7, T4.0H, BT" /AntisenseName="ykzS" /AntisenseCor="-0.65556958045860303" /AntisenseRegPval="-33.700000000000003" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S501" promotor_-35 complement(1360241..1360248) /Source="Nicolas_upshift_promotors" /id="U1124" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.665334665334665" /psig="0.995004995004995" /xcortree=2222 /SigmaFactorBS="aacaattcataagggagataaaactccttatCGCTTTACttc tcaatgaaaaTACTGCAAAATACTTTCAAAaggcattattatgtttaaaggagaggaa g" /listShort="ykvS, S500" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1360274..1360279 /Source="Nicolas_upshift_promotors" /id="U1125" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.664335664335664" /psig="0.999000999001" /xcortree=1831 /SigmaFactorBS="taaagcgataaggagttttatctcccttatgaATTGTTctgt cgctataaagaTGATATATTGATTTTCGTCAatagaaagaaaaggggggaatttttgt t" /listShort="ykzS, ykvT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1360295..1360314 /Source="Nicolas_upshift_promotors" /id="U1125" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.664335664335664" /psig="0.999000999001" /xcortree=1831 /SigmaFactorBS="taaagcgataaggagttttatctcccttatgaATTGTTctgt cgctataaagaTGATATATTGATTTTCGTCAatagaaagaaaaggggggaatttttgt t" /listShort="ykzS, ykvT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1360302 /Source="Nicolas_upshifts" /id="U1125" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.664335664335664" /psig="0.999000999001" /xcortree=1831 /SigmaFactorBS="taaagcgataaggagttttatctcccttatgaATTGTTctgt cgctataaagaTGATATATTGATTTTCGTCAatagaaagaaaaggggggaatttttgt t" /listShort="ykzS, ykvT" /GFF_Attribute="listLong" /label="upshifts" CDS 1360341..1360535 /gene="ykzS" /locus_tag="BSU_13819" /old_locus_tag="BSU13819" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein (HGT island)" /protein_id="YP_003097721.1" /db_xref="EnsemblGenomes-Gn:BSU13819" /db_xref="EnsemblGenomes-Tr:CAX52612" /db_xref="UniProtKB/Swiss-Prot:C0H405" /translation="MRPEEITEMIEQLRTGAINELRVQKEHFLDFRAVLSKQDDFKHF RGIAQQGGDVIFQYLEQPRS*" /label="ykzS CDS" gene 1360341..1360535 /gene="ykzS" /locus_tag="BSU_13819" /old_locus_tag="BSU13819" /label="ykzS gene" downshifts 1360511 /Source="Nicolas_upshifts" /id="D766" /incds=0 /nref=6 /ntot=124 /MaxReadThrough="3.66738" /MaxDrop="3.03929" /score="5.82604583" /energy="-10.6" /TU="U1125" /idTUdmin="U1123" /TUdmin=682 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1360556..1360574) /Source="Nicolas_upshift_promotors" /id="U1126" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1145 /SigmaFactorBS="tactttacattttatttacacctgttacagacagctGTAATA aaaggcttgtgttctgTCATATATGATAAAAAGGCttctcacgtatgagaaaccttca g" /listShort="S501, ykvS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1360572) /Source="Nicolas_upshifts" /id="U1126" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1145 /SigmaFactorBS="tactttacattttatttacacctgttacagacagctGTAATA aaaggcttgtgttctgTCATATATGATAAAAAGGCttctcacgtatgagaaaccttca g" /listShort="S501, ykvS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1360591..1360596) /Source="Nicolas_upshift_promotors" /id="U1126" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1145 /SigmaFactorBS="tactttacattttatttacacctgttacagacagctGTAATA aaaggcttgtgttctgTCATATATGATAAAAAGGCttctcacgtatgagaaaccttca g" /listShort="S501, ykvS" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1360834..1361460 /gene="ykvT" /locus_tag="BSU_13820" /old_locus_tag="BSU13820" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12177332, 12950927, 23199363; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cell wall hydrolase related to spore cortex-lytic enzymes" /protein_id="NP_389265.1" /db_xref="EnsemblGenomes-Gn:BSU13820" /db_xref="EnsemblGenomes-Tr:CAB13255" /db_xref="GOA:O31685" /db_xref="InterPro:IPR011105" /db_xref="SubtiList:BG13322" /db_xref="UniProtKB/Swiss-Prot:O31685" /translation="MTTKFTALAVFLLCFMPAAKIEHTQASLLSAKKTKHEEAKWLTH IDRNTNESFPSLSADKDKKIKPIKLSAHTEKKEKDKPDKTNDEKETYTQSEKELLSRL VHAEAKGESYKGKVAVASVVLNRTEKKGFPDTIRGVIYQKNAFEPVANGSINQKPDKE SIEAAEEALSSKNRETDAIFFYNPKTASDNWIRSRKIVEKIGRHVFAV*" /label="ykvT CDS" gene 1360834..1361460 /gene="ykvT" /locus_tag="BSU_13820" /old_locus_tag="BSU13820" /label="ykvT gene" downshifts 1361391 /Source="Nicolas_upshifts" /id="D767" /incds=1 /nref=1 /ntot=17 /MaxReadThrough="0.932830000000001" /MaxDrop="1.92264" /score="9.80914166" /energy="-11.9" /TU="NA" /idTUdmin="U1125" /TUdmin=44 /isTUend="FALSE" /label="downshifts" promotor_-35 1361517..1361522 /Source="Nicolas_upshift_promotors" /id="U1127" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=991 /SigmaFactorBS="gagacaatttgtctcagctgtgctttttttcatataaagagt aaaaatAAAATAatttttgaacttgtcTCATATGATGTTGGTAGTAcaagagacaagg a" /listShort="ykvU, stoA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1361529 /Source="Nicolas_upshifts" /id="U1127" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=991 /SigmaFactorBS="gagacaatttgtctcagctgtgctttttttcatataaagagt aaaaatAAAATAatttttgaacttgtcTCATATGATGTTGGTAGTAcaagagacaagg a" /listShort="ykvU, stoA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1361538..1361556 /Source="Nicolas_upshift_promotors" /id="U1127" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=991 /SigmaFactorBS="gagacaatttgtctcagctgtgctttttttcatataaagagt aaaaatAAAATAatttttgaacttgtcTCATATGATGTTGGTAGTAcaagagacaagg a" /listShort="ykvU, stoA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1361578..1362915 /gene="ykvU" /locus_tag="BSU_13830" /old_locus_tag="BSU13830" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15686839, 15849754, 16850406, 19648239" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15686839, 15849754, 16850406, 19648239; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="spore membrane protein involved in germination" /protein_id="NP_389266.1" /db_xref="EnsemblGenomes-Gn:BSU13830" /db_xref="EnsemblGenomes-Tr:CAB13256" /db_xref="GOA:O31686" /db_xref="InterPro:IPR002797" /db_xref="InterPro:IPR024923" /db_xref="SubtiList:BG13323" /db_xref="UniProtKB/Swiss-Prot:O31686" /translation="MNRFVKGIILLSIAAFFAECLEFVVNMILARELGEHGMGLYMSI LPTIFLIIVIASLELPISISKFIAESNPKLHESMLRHAFRMTAIFTAFSTAAASIALP FIPVFDTYHPFIKGIVIGLIPVVAFTSIARGYFMGVQKMGKIAIANVLKKIIQLLCLF LFFQWYSFELDMAVLISLFVLVVSDVVVLVYLYSQFIMARRALSGQQHIHLRGKDVRK RLLAVSIPTTGLRIFHAVVNAIEPFLVKGALLAAGVAGTAAIDQYGMLAGVAVTIGSF PAFIAHSLMVVMIPSISEAYALSQYDIVLKRLKQSIFITLGYGIPAVWVMFQFAGPLT HLFFHSPEAQYYLQLLWPYFLFHLFVMPLQACLIGMGFVKEAFYHNVWSHIVALSMMY VLGSMENLQMLGIILGMNTGMILLTSLHYATICKALKVSVFLTGGTRTPRIEG*" /label="ykvU CDS" gene 1361578..1362915 /gene="ykvU" /locus_tag="BSU_13830" /old_locus_tag="BSU13830" /label="ykvU gene" CDS 1362966..1363463 /gene="stoA" /locus_tag="BSU_13840" /old_locus_tag="BSU13840" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15292147, 15322369, 15342593, 19144642, 28383125" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15292147, 15322369, 15342593, 19144642, 28383125; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore-specific thiol-disulfide oxidoreductase (SpoVD maturation)" /protein_id="NP_389267.1" /db_xref="EnsemblGenomes-Gn:BSU13840" /db_xref="EnsemblGenomes-Tr:CAB13257" /db_xref="GOA:O31687" /db_xref="InterPro:IPR000866" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR017937" /db_xref="InterPro:IPR036249" /db_xref="PDB:3ERW" /db_xref="SubtiList:BG13324" /db_xref="UniProtKB/Swiss-Prot:O31687" /translation="MLTKRLLTIYIMLLGLIAWFPGAAQAEEKQPAVPAVFLMKTIEG EDISIPNKGQKTILHFWTSWCPPCKKELPQFQSFYDAHPSDSVKLVTVNLVNSEQNQQ VVEDFIKANKLTFPIVLDSKGELMKEYHIITIPTSFLLNEKGEIEKTKIGPMTAEQLK EWTEE*" /label="stoA CDS" gene 1362966..1363463 /gene="stoA" /locus_tag="BSU_13840" /old_locus_tag="BSU13840" /label="stoA gene" promotor_-35 1363312..1363318 /Source="Nicolas_upshift_promotors" /id="U1128" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=267 /SigmaFactorBS="agcaagtcgttgaagactttattaaagcaaacaagctgacgt ttcCGATTGTccttgactcaaaagGGGAATTGATGAAGGAGTAtcatatcatcacgat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1363327 /Source="Nicolas_upshifts" /id="U1128" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=267 /SigmaFactorBS="agcaagtcgttgaagactttattaaagcaaacaagctgacgt ttcCGATTGTccttgactcaaaagGGGAATTGATGAAGGAGTAtcatatcatcacgat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1363333..1363351 /Source="Nicolas_upshift_promotors" /id="U1128" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=267 /SigmaFactorBS="agcaagtcgttgaagactttattaaagcaaacaagctgacgt ttcCGATTGTccttgactcaaaagGGGAATTGATGAAGGAGTAtcatatcatcacgat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 1363437 /Source="Nicolas_upshifts" /id="D768" /incds=0 /nref=36 /ntot=164 /MaxReadThrough="1.89069" /MaxDrop="4.34947" /score="14.1388498" /energy="-11.3" /TU="NA" /idTUdmin="U1127" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1363558..1363564 /Source="Nicolas_upshift_promotors" /id="U1129" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.832167832167832" /psig=1 /xcortree=1532 /SigmaFactorBS="tattatcaaaaagaaattaaaataattataaTTGAAATtctc ttcgtgCGTGCTATAATAAAGGAAGAcatcaagaaataactgacgataaagctgcctt t" /listShort="S502, zosA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1363575..1363594 /Source="Nicolas_upshift_promotors" /id="U1129" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.832167832167832" /psig=1 /xcortree=1532 /SigmaFactorBS="tattatcaaaaagaaattaaaataattataaTTGAAATtctc ttcgtgCGTGCTATAATAAAGGAAGAcatcaagaaataactgacgataaagctgcctt t" /listShort="S502, zosA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1363587 /Source="Nicolas_upshifts" /id="U1129" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.832167832167832" /psig=1 /xcortree=1532 /SigmaFactorBS="tattatcaaaaagaaattaaaataattataaTTGAAATtctc ttcgtgCGTGCTATAATAAAGGAAGAcatcaagaaataactgacgataaagctgcctt t" /listShort="S502, zosA" /GFF_Attribute="listLong" /label="upshifts" S_feature 1363591..1363698 /Source="Nicolas_S_feature" /locus_tag="new_1451263_1451370" /HighExp="LBGstat, C90, Lbstat, BC, Cold, T0.30H, Etha, Lbtran, LBGtran, BI" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S502" CDS 1363699..1365612 /gene="pfeT" /locus_tag="BSU_13850" /old_locus_tag="BSU13850" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12029044, 12180919, 15802251, 21813502, 26261021, 26566138" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12029044, 12180919, 15802251, 21813502, 26261021, 26566138; Product type t : transporter" /codon_start=1 /transl_table=11 /product="Fe(II) efflux transporter possibly involved in copper(II) uptake" /protein_id="NP_389268.1" /db_xref="EnsemblGenomes-Gn:BSU13850" /db_xref="EnsemblGenomes-Tr:CAB13258" /db_xref="GOA:O31688" /db_xref="InterPro:IPR001757" /db_xref="InterPro:IPR008250" /db_xref="InterPro:IPR018303" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR023298" /db_xref="InterPro:IPR023299" /db_xref="InterPro:IPR027256" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG13325" /db_xref="UniProtKB/Swiss-Prot:O31688" /translation="MNEQVIVQRDPHEPLKTDKREKNWAQHAELIAALVSGALILAGW LLSGYQVLSIILFLLAFVIGGFAKAKEGIEETLESKTLNVELLMIFAAIGSALIGYWA EGAILIFIFSLSGALETYTMNKSSRDLTSLMQLEPEEATLMVNGETKRVPVSDLQAGD MIVIKPGERVAADGIIESGSTSLDESALTGESMPVEKNTGDTVFTGTVNRNGSLTVRV TKANEDSLFRKIIKLVESAQNSVSPAQAFIERFENAYVKGVLIAVALLLFVPHFALGW SWSETFYRAMVFMVVASPCALVASIMPAALSLISNGARNGMLVKGSVFLEQLGSVQMI AFDKTGTVTKGQPAVETIRIAEGFSEAEVLEAVYAIETQSSHPLAQAITAYAESRGVN QSGYISIEETSGFGVMAEVSGAKWKVGKAGFIGEEMAAQFMKQTASDVIQSGHTIVFV KKDDQIAGCIALKDQIRPEAKEVMEELNRLGIKTAMLTGDHEDTAQAIAKEAGMTTVV AECLPDQKVNEIKRLKEEFGTIAMVGDGINDAPALKAADVGIAMGGGTDVALETADMV LMKNDLKKLVNMCRLSRKMNRIIKQNIVFSLAVICLLICANFLQAMELPFGVIGHEGS TILVILNGLRLLK*" /label="pfeT CDS" gene 1363699..1365612 /gene="pfeT" /locus_tag="BSU_13850" /old_locus_tag="BSU13850" /label="pfeT gene" promotor_-10 complement(1363848..1363867) /Source="Nicolas_upshift_promotors" /id="U1130" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1375 /SigmaFactorBS="gtttcttcgattccttccttcgctttagcaaatccgCCGATC ACAAaagccagcaagaAAAGTATTATGGATAATACCtgatatccggataagagccagc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1363865) /Source="Nicolas_upshifts" /id="U1130" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1375 /SigmaFactorBS="gtttcttcgattccttccttcgctttagcaaatccgCCGATC ACAAaagccagcaagaAAAGTATTATGGATAATACCtgatatccggataagagccagc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1363880..1363889) /Source="Nicolas_upshift_promotors" /id="U1130" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1375 /SigmaFactorBS="gtttcttcgattccttccttcgctttagcaaatccgCCGATC ACAAaagccagcaagaAAAGTATTATGGATAATACCtgatatccggataagagccagc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1364016..1364035) /Source="Nicolas_upshift_promotors" /id="U1131" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=748 /SigmaFactorBS="gctgcattaaagacgttaaatctctgctgcttttattcatcg tgtaTGTTTCTaaagctccgcttaAGGAAAAAATAAATATTAAAatagcaccctctgc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1364041) /Source="Nicolas_upshifts" /id="U1131" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=748 /SigmaFactorBS="gctgcattaaagacgttaaatctctgctgcttttattcatcg tgtaTGTTTCTaaagctccgcttaAGGAAAAAATAAATATTAAAatagcaccctctgc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1364049..1364055) /Source="Nicolas_upshift_promotors" /id="U1131" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=748 /SigmaFactorBS="gctgcattaaagacgttaaatctctgctgcttttattcatcg tgtaTGTTTCTaaagctccgcttaAGGAAAAAATAAATATTAAAatagcaccctctgc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1365593 /Source="Nicolas_upshifts" /id="D769" /incds=0 /nref=62 /ntot=148 /MaxReadThrough="2.05978" /MaxDrop="6.90668" /score="30.2111295" /energy="-18" /TU="NA" /idTUdmin="U1129" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1365669) /Source="Nicolas_upshifts" /id="D770" /incds=0 /nref=74 /ntot=208 /MaxReadThrough="0.83751" /MaxDrop="4.23141" /score="34.2342147" /energy="-18" /TU="NA" /idTUdmin="U1132" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1365880..1365899) /Source="Nicolas_upshift_promotors" /id="U1132" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.684315684315684" /psig="0.999000999001" /xcortree=3126 /SigmaFactorBS="gcctttcacgacgccttcattttctaatgCATTTTATttcct gctcctctTCCTGTATACTGACAGTAACgttcaatcgcaggggggttgttccgtttgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1365889) /Source="Nicolas_upshifts" /id="U1132" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.684315684315684" /psig="0.999000999001" /xcortree=3126 /SigmaFactorBS="gcctttcacgacgccttcattttctaatgCATTTTATttcct gctcctctTCCTGTATACTGACAGTAACgttcaatcgcaggggggttgttccgtttgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1365913..1365920) /Source="Nicolas_upshift_promotors" /id="U1132" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.684315684315684" /psig="0.999000999001" /xcortree=3126 /SigmaFactorBS="gcctttcacgacgccttcattttctaatgCATTTTATttcct gctcctctTCCTGTATACTGACAGTAACgttcaatcgcaggggggttgttccgtttgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 1365964..1365983 /Source="Nicolas_upshift_promotors" /id="U1133" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.434565434565435" /psig=1 /xcortree=1996 /SigmaFactorBS="taaaatgcattagaaaatgaaggcgtcgtgaaaggcaaacac cggtaaaaCCTGTTACAATGGAAGACAGaacaatgcattgcaaatggcagggaggaac a" /listShort="ykvY, S504, ykvZ, glcT, S505, ptsG, ptsH, ptsI" /listLong="splA, splB" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1365974 /Source="Nicolas_upshifts" /id="U1133" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.434565434565435" /psig=1 /xcortree=1996 /SigmaFactorBS="taaaatgcattagaaaatgaaggcgtcgtgaaaggcaaacac cggtaaaaCCTGTTACAATGGAAGACAGaacaatgcattgcaaatggcagggaggaac a" /listShort="ykvY, S504, ykvZ, glcT, S505, ptsG, ptsH, ptsI" /listLong="splA, splB" /label="upshifts" CDS 1366019..1367110 /gene="papB" /locus_tag="BSU_13860" /old_locus_tag="BSU13860" /EC_number="3.4.13.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7770058, 23144141" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7770058, 23144141; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="Xaa-Pro Xaa-Pro-Xaa di-tri-peptidase used in osmoprotection" /protein_id="NP_389269.1" /db_xref="EnsemblGenomes-Gn:BSU13860" /db_xref="EnsemblGenomes-Tr:CAB13259" /db_xref="GOA:O31689" /db_xref="InterPro:IPR000587" /db_xref="InterPro:IPR000994" /db_xref="InterPro:IPR001131" /db_xref="InterPro:IPR001714" /db_xref="InterPro:IPR029149" /db_xref="InterPro:IPR036005" /db_xref="SubtiList:BG13326" /db_xref="UniProtKB/Swiss-Prot:O31689" /translation="MNRIQRVSSWLKEAGHTAAFIHTKENVFYLTGFYTEPHERLMGL FIFQEEEPFFVCPGMEAGQARNAGWNHEIIGYADHENPWELIEKALKKRNISIHMLAV EKDSISLSRAEQLKHATGGAQFVSAEETLNQFRLIKDDNEIRLLKEAAKLADYGVEVG TAALREGISEVEVLAQIEYELKKKGIQGMSFSTMVLFGEKSGQPHGNPGTATLKKGDF VLFDLGVILDGYCSDITRTFAYKTINPKQEAIYETVLQAEKAAIEASKPGVRIGDLDL TARGIIEKAGYGDYFPHRLGHGLGISVHEYPSMSQANDTLLQEGMVYTIEPGIYVPEI GGVRIEDDVHVTKDGAVALTQYPKDLIIL*" /label="papB CDS" gene 1366019..1367110 /gene="papB" /locus_tag="BSU_13860" /old_locus_tag="BSU13860" /label="papB gene" downshifts 1366759 /Source="Nicolas_upshifts" /id="D771" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="6.10599" /MaxDrop="5.06339" /score="-5.18621526" /energy="-6.2" /TU="U1133" /idTUdmin="U1129" /TUdmin=1166 /isTUend="FALSE" /label="downshifts" downshifts 1367089 /Source="Nicolas_upshifts" /id="D772" /incds=0 /nref=2 /ntot=52 /MaxReadThrough="5.66039" /MaxDrop="2.56719" /score="-5.18621526" /energy="-6.2" /TU="U1133" /idTUdmin="U1129" /TUdmin=1496 /isTUend="FALSE" /label="downshifts" S_feature complement(1367123..1367341) /Source="Nicolas_S_feature" /locus_tag="new_1454795_1455013_c" /HighExp="B60, B36, C30, G135, LBGstat, S8, Lbstat, C90, Etha, S7" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.92748200000000003" /TUshortSig="SigA" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S503" S_feature 1367134..1367391 /Source="Nicolas_S_feature" /locus_tag="new_1454806_1455063" /HighExp="dia15, dia5, Etha, M0t90, M40t90, Lbstat, H2O2, G150, Mt0, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S504" promotor_-10 complement(1367328..1367347) /Source="Nicolas_upshift_promotors" /id="U1134" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.906093906093906" /psig="0.992007992007992" /xcortree=603 /SigmaFactorBS="tattagccatagattcccttctttctaaatcCCCTTGATctg gaatgcgtttcaTACAATATGATATGGACGTAccagatatctttttgtgtttttagct g" /listShort="S503" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1367341) /Source="Nicolas_upshifts" /id="U1134" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.906093906093906" /psig="0.992007992007992" /xcortree=603 /SigmaFactorBS="tattagccatagattcccttctttctaaatcCCCTTGATctg gaatgcgtttcaTACAATATGATATGGACGTAccagatatctttttgtgtttttagct g" /listShort="S503" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1367363..1367370) /Source="Nicolas_upshift_promotors" /id="U1134" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.906093906093906" /psig="0.992007992007992" /xcortree=603 /SigmaFactorBS="tattagccatagattcccttctttctaaatcCCCTTGATctg gaatgcgtttcaTACAATATGATATGGACGTAccagatatctttttgtgtttttagct g" /listShort="S503" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1367392..1368357 /gene="ykvZ" /locus_tag="BSU_13870" /old_locus_tag="BSU13870" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (LacI family)" /protein_id="NP_389270.1" /db_xref="EnsemblGenomes-Gn:BSU13870" /db_xref="EnsemblGenomes-Tr:CAB13260" /db_xref="GOA:O31690" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR001761" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG13327" /db_xref="UniProtKB/Swiss-Prot:O31690" /translation="MANIKDIAEKAGVSVTTVSRVINNHPYVSEDKRKRVFEAMESLE YTRNIHAVHLSKGFSNMIGVVLPTVNLPYFAELIAGIADAAAESGVHLSLFQTNYEVQ KEIFALSQLKQRQVDGLIFCSKALADEKLMEWEGPILLCQNSDNARFPTISIPHQEAF RNGLDYLIAKGHKKIAICLARKKGMNSHFRIKAYKEALEEIGEAFREDWVIEKAITIN DGKALFHKWNTWKEKPTAIFVANDQVSAGLFLEAKNQRVSVPDELAILSVDNHEISQA LGITTIDIQTREMGKQAFAILEKRIQGQPIERKVLDYRLIERSTV*" /label="ykvZ CDS" gene 1367392..1368357 /gene="ykvZ" /locus_tag="BSU_13870" /old_locus_tag="BSU13870" /label="ykvZ gene" promotor_-35 1368375..1368382 /Source="Nicolas_upshift_promotors" /id="U1135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.555444555444555" /psig="0.988011988011988" /xcortree=2551 /SigmaFactorBS="actgtttagtgaatgcattgaaaaaaGGTTTGACgtgcattc tgttcgTTATGTACGATATGAGGTATtgaatgacaaaggagctgaggatcgtgaatgg g" /listShort="glcT, S505" /listLong="ptsG, ptsH, ptsI, splA, splB" /label="promotor_-35" promotor_-10 1368397..1368416 /Source="Nicolas_upshift_promotors" /id="U1135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.555444555444555" /psig="0.988011988011988" /xcortree=2551 /SigmaFactorBS="actgtttagtgaatgcattgaaaaaaGGTTTGACgtgcattc tgttcgTTATGTACGATATGAGGTATtgaatgacaaaggagctgaggatcgtgaatgg g" /listShort="glcT, S505" /listLong="ptsG, ptsH, ptsI, splA, splB" /label="promotor_-10" upshifts 1368409 /Source="Nicolas_upshifts" /id="U1135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.555444555444555" /psig="0.988011988011988" /xcortree=2551 /SigmaFactorBS="actgtttagtgaatgcattgaaaaaaGGTTTGACgtgcattc tgttcgTTATGTACGATATGAGGTATtgaatgacaaaggagctgaggatcgtgaatgg g" /listShort="glcT, S505" /listLong="ptsG, ptsH, ptsI, splA, splB" /label="upshifts" CDS 1368420..1369286 /gene="glcT" /locus_tag="BSU_13880" /old_locus_tag="BSU13880" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10974121, 14527945, 15155854, 17074746, 22750856" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10974121, 14527945, 15155854, 17074746, 22750856; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional antiterminator (BglG family)" /protein_id="NP_389271.2" /db_xref="EnsemblGenomes-Gn:BSU13880" /db_xref="EnsemblGenomes-Tr:CAB13261" /db_xref="GOA:O31691" /db_xref="InterPro:IPR001550" /db_xref="InterPro:IPR004341" /db_xref="InterPro:IPR011608" /db_xref="InterPro:IPR036634" /db_xref="InterPro:IPR036650" /db_xref="PDB:3GWH" /db_xref="PDB:3RIO" /db_xref="PDB:3UFE" /db_xref="SubtiList:BG12593" /db_xref="UniProtKB/Swiss-Prot:O31691" /translation="MTKELRIVNGSFTVKKVLNNNVLIASHHKYSEVVLIGKGIGFGK KQDDVIEDKGYDKMFILKDEKEQKQFKKLLDYVDEKLVDISNDVIYHISNRTNHSLNE HIHIALTDHIAFAIKRQQQGFDMKNPFLMETQSLYPEEYQIAKEVIDMINEKAGLCLP EGEIGFIALHIHSALTNRPLSEVNQHSQLMAQLVEVIEDSFQMKVNKESVNYLRLIRH IRFTIERIKKEEPTKEPEKLMLLLKNEYPLCYNTAWKLIKILQQTLKKPVHEAEAVYL TLHLYRLTNKIS*" /label="glcT CDS" gene 1368420..1369286 /gene="glcT" /locus_tag="BSU_13880" /old_locus_tag="BSU13880" /label="glcT gene" promotor_-35 1369141..1369145 /Source="Nicolas_upshift_promotors" /id="U1136" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.925074925074925" /psig=1 /xcortree=2686 /SigmaFactorBS="ccgactaaagaaccagaaaaattaatgttgtTATTGaaaaat gaatatccgcTATGCTACAATACAGCTTGGaaattgattaaaatcttgcagcaaacat t" /listShort="S505, ptsG, ptsH, ptsI, splA, splB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1369162..1369181 /Source="Nicolas_upshift_promotors" /id="U1136" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.925074925074925" /psig=1 /xcortree=2686 /SigmaFactorBS="ccgactaaagaaccagaaaaattaatgttgtTATTGaaaaat gaatatccgcTATGCTACAATACAGCTTGGaaattgattaaaatcttgcagcaaacat t" /listShort="S505, ptsG, ptsH, ptsI, splA, splB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1369170 /Source="Nicolas_upshifts" /id="U1136" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.925074925074925" /psig=1 /xcortree=2686 /SigmaFactorBS="ccgactaaagaaccagaaaaattaatgttgtTATTGaaaaat gaatatccgcTATGCTACAATACAGCTTGGaaattgattaaaatcttgcagcaaacat t" /listShort="S505, ptsG, ptsH, ptsI, splA, splB" /GFF_Attribute="listLong" /label="upshifts" downshifts 1369288 /Source="Nicolas_upshifts" /id="D773" /incds=0 /nref=1 /ntot=30 /MaxReadThrough="9.01653" /MaxDrop="3.09921" /score="-5.18621526" /energy="-6.2" /TU="U1133,U1135,U1136" /idTUdmin="U1135" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" misc_RNA 1369333..1369484 /gene="gswA" /locus_tag="BSU_misc_RNA_88" /product="riboswitch regulating ptsGHI expression via GlcTbinding" /experiment="publication(s) with functional evidences, PMID:15155854, 22750856" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15155854, 22750856; Product type n: RNA" /label="gswA RNA" S_feature 1369333..1369484 /Source="Nicolas_S_feature" /locus_tag="new_1457005_1457156" /HighExp="LBGexp, G150, C30, G135, G180, MG 90, dia0, Lbexp, dia15, GM-0.1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 0.988, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S505" gene 1369333..1369484 /gene="gswA" /locus_tag="BSU_misc_RNA_88" /label="gswA gene" promotor_-35 1369462..1369468 /Source="Nicolas_upshift_promotors" /id="U1137" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.752247752247752" /psig="0.752247752247752" /xcortree=1446 /SigmaFactorBS="cggttaaactggaagacttacgcctgtgaattcgttGTCATG AtttttagctgtaaGGTCAGACTAGTaaaaagaggaggtcaattcttatgtttaaagc a" /listShort="ptsG, ptsH, ptsI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1369482..1369493 /Source="Nicolas_upshift_promotors" /id="U1137" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.752247752247752" /psig="0.752247752247752" /xcortree=1446 /SigmaFactorBS="cggttaaactggaagacttacgcctgtgaattcgttGTCATG AtttttagctgtaaGGTCAGACTAGTaaaaagaggaggtcaattcttatgtttaaagc a" /listShort="ptsG, ptsH, ptsI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1369486 /Source="Nicolas_upshifts" /id="U1137" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.752247752247752" /psig="0.752247752247752" /xcortree=1446 /SigmaFactorBS="cggttaaactggaagacttacgcctgtgaattcgttGTCATG AtttttagctgtaaGGTCAGACTAGTaaaaagaggaggtcaattcttatgtttaaagc a" /listShort="ptsG, ptsH, ptsI" /GFF_Attribute="listLong" /label="upshifts" CDS 1369515..1371614 /gene="ptsG" /locus_tag="BSU_13890" /old_locus_tag="BSU13890" /EC_number="2.7.1.199" /function="16.1: Circulate" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1447219, 8418852, 8432747, 9593197, 14527945, 15849754, 16850406, 22846916" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1447219, 8418852, 8432747, 9593197, 14527945, 15849754, 16850406, 22846916; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) glucose-specificenzyme IICBA component" /protein_id="NP_389272.1" /db_xref="EnsemblGenomes-Gn:BSU13890" /db_xref="EnsemblGenomes-Tr:CAB13262" /db_xref="GOA:P20166" /db_xref="InterPro:IPR001127" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR004719" /db_xref="InterPro:IPR011055" /db_xref="InterPro:IPR011299" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="PDB:1AX3" /db_xref="PDB:1GPR" /db_xref="SubtiList:BG10198" /db_xref="UniProtKB/Swiss-Prot:P20166" /translation="MFKALFGVLQKIGRALMLPVAILPAAGILLAIGNAMQNKDMIQV LHFLSNDNVQLVAGVMESAGQIVFDNLPLLFAVGVAIGLANGDGVAGIAAIIGYLVMN VSMSAVLLANGTIPSDSVERAKFFTENHPAYVNMLGIPTLATGVFGGIIVGVLAALLF NRFYTIELPQYLGFFAGKRFVPIVTSISALILGLIMLVIWPPIQHGLNAFSTGLVEAN PTLAAFIFGVIERSLIPFGLHHIFYSPFWYEFFSYKSAAGEIIRGDQRIFMAQIKDGV QLTAGTFMTGKYPFMMFGLPAAALAIYHEAKPQNKKLVAGIMGSAALTSFLTGITEPL EFSFLFVAPVLFAIHCLFAGLSFMVMQLLNVKIGMTFSGGLIDYFLFGILPNRTAWWL VIPVGLGLAVIYYFGFRFAIRKFNLKTPGREDAAEETAAPGKTGEAGDLPYEILQAMG DQENIKHLDACITRLRVTVNDQKKVDKDRLKQLGASGVLEVGNNIQAIFGPRSDGLKT QMQDIIAGRKPRPEPKTSAQEEVGQQVEEVIAEPLQNEIGEEVFVSPITGEIHPITDV PDQVFSGKMMGDGFAILPSEGIVVSPVRGKILNVFPTKHAIGLQSDGGREILIHFGID TVSLKGEGFTSFVSEGDRVEPGQKLLEVDLDAVKPNVPSLMTPIVFTNLAEGETVSIK ASGSVNREQEDIVKIEK*" /label="ptsG CDS" gene 1369515..1371614 /gene="ptsG" /locus_tag="BSU_13890" /old_locus_tag="BSU13890" /label="ptsG gene" promotor_-35 1371632..1371636 /Source="Nicolas_upshift_promotors" /id="U1138" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=2687 /SigmaFactorBS="attgaaaaataagggtgttagtacgccgtGCTTGtcagatga caagtacGGTTGTATGATATAATATTGtgaagtaataaagctttaagttaaaaggaga a" /listShort="ptsH, ptsI, splA, splB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1371652..1371671 /Source="Nicolas_upshift_promotors" /id="U1138" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=2687 /SigmaFactorBS="attgaaaaataagggtgttagtacgccgtGCTTGtcagatga caagtacGGTTGTATGATATAATATTGtgaagtaataaagctttaagttaaaaggaga a" /listShort="ptsH, ptsI, splA, splB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1371663 /Source="Nicolas_upshifts" /id="U1138" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=2687 /SigmaFactorBS="attgaaaaataagggtgttagtacgccgtGCTTGtcagatga caagtacGGTTGTATGATATAATATTGtgaagtaataaagctttaagttaaaaggaga a" /listShort="ptsH, ptsI, splA, splB" /GFF_Attribute="listLong" /label="upshifts" CDS 1371712..1371978 /gene="ptsH" /locus_tag="BSU_13900" /old_locus_tag="BSU13900" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10217795, 12411438, 14527945, 15126459, 16267306, 17085448, 17142398, 17726680, 20487301, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10217795, 12411438, 14527945, 15126459, 16267306, 17085448, 17142398, 17726680, 20487301, 25355936; Product type f: factor" /codon_start=1 /transl_table=11 /product="histidine-containing phosphocarrier protein of the phosphotransferase system (PTS) (HPr protein)" /protein_id="NP_389273.1" /db_xref="EnsemblGenomes-Gn:BSU13900" /db_xref="EnsemblGenomes-Tr:CAB13263" /db_xref="GOA:P08877" /db_xref="InterPro:IPR000032" /db_xref="InterPro:IPR001020" /db_xref="InterPro:IPR002114" /db_xref="InterPro:IPR035895" /db_xref="PDB:1JEM" /db_xref="PDB:1KKL" /db_xref="PDB:1KKM" /db_xref="PDB:1SPH" /db_xref="PDB:2FEP" /db_xref="PDB:2HID" /db_xref="PDB:2HPR" /db_xref="PDB:3OQM" /db_xref="PDB:3OQN" /db_xref="PDB:3OQO" /db_xref="SubtiList:BG10200" /db_xref="UniProtKB/Swiss-Prot:P08877" /translation="MAQKTFKVTADSGIHARPATVLVQTASKYDADVNLEYNGKTVNL KSIMGVMSLGIAKGAEITISASGADENDALNALEETMKSEGLGE*" /label="ptsH CDS" gene 1371712..1371978 /gene="ptsH" /locus_tag="BSU_13900" /old_locus_tag="BSU13900" /label="ptsH gene" CDS 1371978..1373690 /gene="ptsI" /locus_tag="BSU_13910" /old_locus_tag="BSU13910" /EC_number="2.7.3.9" /function="16.1: Circulate" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:3106335, 11902727, 15155854, 15670601, 25355936, 26159071" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3106335, 11902727, 15155854, 15670601, 25355936, 26159071; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) enzyme I" /protein_id="NP_389274.2" /db_xref="EnsemblGenomes-Gn:BSU13910" /db_xref="EnsemblGenomes-Tr:CAB13264" /db_xref="GOA:P08838" /db_xref="InterPro:IPR000121" /db_xref="InterPro:IPR006318" /db_xref="InterPro:IPR008279" /db_xref="InterPro:IPR008731" /db_xref="InterPro:IPR015813" /db_xref="InterPro:IPR018274" /db_xref="InterPro:IPR023151" /db_xref="InterPro:IPR024692" /db_xref="InterPro:IPR036618" /db_xref="SubtiList:BG10201" /db_xref="UniProtKB/Swiss-Prot:P08838" /translation="MQELKGIGASAGIAIAKAYRLEEPDLTVEKKNISDSEAEVSRFD EAIARSKEELEKIKEHALKELGQDKADIFSAHLLVLSDPELLNPVKEKISTDSVNAEF ALKETSSMFVTMFESMDNEYMKERAADIRDVTKRVTGHLLGVEIPNPSMISEEVIIVA EDLTPSDTAQLNREFVKGFTTDIGGRTSHSAIMARSLEIPAVVGTKAATGTIQNGVTV IVDGINGDVIIDPSAETVKEYEEKHNAYLAQKAEWAKLVNEPTVSKDGHHVELAANIG TPDDVKGVLENGGEAVGLYRTEFLYMGRDQLPTEDEQFDAYKTVLERMEGKSVVVRTL DIGGDKELPYLQLPKEMNPFLGYRAIRLCLEEQEIFRTQLRALLRASTYGNLKIMFPM IATVNEFKEAKAILLEEKEKLVKAGQAVSDDIEVGMMVEIPSTAVIADQFAKEVDFFS IGTNDLIQYTMAADRMNERVSYLYQPYNPAILRLITLVIEAAHKEGKWVGMCGEMAGD EIAIPILLGLGLDEFSMSATSILPARTQISKLSKQEAESFKEKILSMSTTEEVVAFVK ETFK*" /label="ptsI CDS" gene 1371978..1373690 /gene="ptsI" /locus_tag="BSU_13910" /old_locus_tag="BSU13910" /label="ptsI gene" downshifts 1373677 /Source="Nicolas_upshifts" /id="D774" /incds=0 /nref=116 /ntot=277 /MaxReadThrough="5.0255" /MaxDrop="5.64321" /score="21.2608168" /energy="-12.3" /TU="U1136,U1138" /idTUdmin="U1133" /TUdmin=11 /isTUend="TRUE" /label="downshifts" promotor_-35 1373730..1373736 /Source="Nicolas_upshift_promotors" /id="U1139" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=850 /SigmaFactorBS="acaaaaaccagacggcctccggcctgtctggtttttTTCATA AgtaagggtatagaaGGACACAATAACatggctaggagggatagtatgtcaaaccaat t" /listShort="splA, splB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1373751..1373762 /Source="Nicolas_upshift_promotors" /id="U1139" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=850 /SigmaFactorBS="acaaaaaccagacggcctccggcctgtctggtttttTTCATA AgtaagggtatagaaGGACACAATAACatggctaggagggatagtatgtcaaaccaat t" /listShort="splA, splB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1373754 /Source="Nicolas_upshifts" /id="U1139" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=850 /SigmaFactorBS="acaaaaaccagacggcctccggcctgtctggtttttTTCATA AgtaagggtatagaaGGACACAATAACatggctaggagggatagtatgtcaaaccaat t" /listShort="splA, splB" /GFF_Attribute="listLong" /label="upshifts" CDS 1373781..1374020 /gene="splA" /locus_tag="BSU_13920" /old_locus_tag="BSU13920" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9009064, 9323362, 10629212" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9009064, 9323362, 10629212; Product type r: regulator" /codon_start=1 /transl_table=11 /product="TRAP-like transcriptional negative regulator of spore photoproduct lyase" /protein_id="NP_389275.1" /db_xref="EnsemblGenomes-Gn:BSU13920" /db_xref="EnsemblGenomes-Tr:CAB13265" /db_xref="GOA:P37955" /db_xref="InterPro:IPR022608" /db_xref="SubtiList:BG10202" /db_xref="UniProtKB/Swiss-Prot:P37955" /translation="MSNQFNAGDTVYVIYRNPHAANVAHIKEAEIVHHPYHEGELSLF IYETYHPFAEDDAVFASYEEAKSLYKELFDIDPYE*" /label="splA CDS" gene 1373781..1374020 /gene="splA" /locus_tag="BSU_13920" /old_locus_tag="BSU13920" /label="splA gene" S_feature complement(1373801..1375140) /Source="Nicolas_S_feature" /locus_tag="new_1461473_1462812_c" /HighExp="T4.0H, T3.30H, T3.0H, S3, S1, T2.0H, T2.30H, S2, T5.0H, S4" /AntisenseName="splB" /AntisenseCor="-0.193138593783996" /AntisenseRegPval="-2.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S506" CDS 1374098..1375126 /gene="splB" /locus_tag="BSU_13930" /old_locus_tag="BSU13930" /EC_number="4.1.99.14" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9733691, 10629212, 11053385, 11470912, 16829680, 16829676, 17293412, 18055591, 22197590, 22961846, 23607538, 24598744, 28027411" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9733691, 10629212, 11053385, 11470912, 16829680, 16829676, 17293412, 18055591, 22197590, 22961846, 23607538, 24598744, 28027411; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore photoproduct (thymine dimer) lyase" /protein_id="NP_389276.1" /db_xref="EnsemblGenomes-Gn:BSU13930" /db_xref="EnsemblGenomes-Tr:CAB13266" /db_xref="GOA:P37956" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR023897" /db_xref="InterPro:IPR034560" /db_xref="SubtiList:BG10203" /db_xref="UniProtKB/Swiss-Prot:P37956" /translation="MQNPFVPQLVYIEPRALEYPLGQELQDKFENMGIEIRETTSHNQ VRNIPGKNHLQQYRNAKSTLVIGVRKTLKFDSSKPSAEYAIPFATGCMGHCHYCYLQT TMGSKPYIRTYVNVEEILDQADKYMKERAPEFTRFEASCTSDIVGIDHLTHTLKRAIE HFGQSDLGKLRFVTKFHHVDHLLDAKHNGKTRFRFSINADYVIKNFEPGTSPLDKRIE AAVKVAKAGYPLGFIVAPIYIHEGWEEGYRHLFEKLDAALPQDVRHDITFELIQHRFT KPAKRVIEKNYPKTKLELDEEKRRYKWGRYGIGKYIYQKDEEHALREALESYIDTFFP NAKIEYFT*" /label="splB CDS" gene 1374098..1375126 /gene="splB" /locus_tag="BSU_13930" /old_locus_tag="BSU13930" /label="splB gene" downshifts 1375096 /Source="Nicolas_upshifts" /id="D775" /incds=0 /nref=5 /ntot=113 /MaxReadThrough="0.352" /MaxDrop="3.95383" /score="15.9223136" /energy="-13.2" /TU="NA" /idTUdmin="U1136" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1375141..1375821) /gene="ykwB" /locus_tag="BSU_13940" /old_locus_tag="BSU13940" /function="18.1: Enzymes of unknown specificity" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase / amidohydrolase" /protein_id="NP_389277.2" /db_xref="EnsemblGenomes-Gn:BSU13940" /db_xref="EnsemblGenomes-Tr:CAB13267" /db_xref="GOA:Q796K9" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG12252" /db_xref="UniProtKB/Swiss-Prot:Q796K9" /translation="MIILKQMYVHDGRKFEALTIRNYTETDIERLISLQEECFPPPFP QELLWSEDQLASHIKTFPEGALCALINGRIIGSMTALIVQFEPDSPDHTWAQATDNGS IKNHEPHGNTLYVVDISVSPHYRKLGIGKWLMNTMYELTVDKRLERLLGGGRIPLYYK YAHEISAVQYVEDVMEGRKNDPVLSFLLRCGRSPIRVVSNYLEDKESLNYGVLMEWKN VFYKKASC*" /label="ykwB CDS" gene complement(1375141..1375821) /gene="ykwB" /locus_tag="BSU_13940" /old_locus_tag="BSU13940" /label="ykwB gene" promotor_-10 complement(1375831..1375850) /Source="Nicolas_upshift_promotors" /id="U1140" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=2873 /SigmaFactorBS="aaaatgaataatcaaaaaataaattataagaaaatcggaata TATTTACTgaaaattcaatcttCGTTATAATGAAACAACATAaggagagtgatgatca t" /listShort="ykwB, S506" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1375854) /Source="Nicolas_upshifts" /id="U1140" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=2873 /SigmaFactorBS="aaaatgaataatcaaaaaataaattataagaaaatcggaata TATTTACTgaaaattcaatcttCGTTATAATGAAACAACATAaggagagtgatgatca t" /listShort="ykwB, S506" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1375865..1375872) /Source="Nicolas_upshift_promotors" /id="U1140" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=2873 /SigmaFactorBS="aaaatgaataatcaaaaaataaattataagaaaatcggaata TATTTACTgaaaattcaatcttCGTTATAATGAAACAACATAaggagagtgatgatca t" /listShort="ykwB, S506" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1375906..1375913 /Source="Nicolas_upshift_promotors" /id="U1141" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2802 /SigmaFactorBS="tattccgattttcttataatttattttttgattATTCATTTt tcaaacgaaaggGCCGATATAGAAATTAGGAggggattggtttgtttaaaaaacttca c" /listShort="mcpC" /listLong="ykwC" /label="promotor_-35" promotor_-10 1375927..1375945 /Source="Nicolas_upshift_promotors" /id="U1141" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2802 /SigmaFactorBS="tattccgattttcttataatttattttttgattATTCATTTt tcaaacgaaaggGCCGATATAGAAATTAGGAggggattggtttgtttaaaaaacttca c" /listShort="mcpC" /listLong="ykwC" /label="promotor_-10" upshifts 1375933 /Source="Nicolas_upshifts" /id="U1141" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2802 /SigmaFactorBS="tattccgattttcttataatttattttttgattATTCATTTt tcaaacgaaaggGCCGATATAGAAATTAGGAggggattggtttgtttaaaaaacttca c" /listShort="mcpC" /listLong="ykwC" /label="upshifts" CDS 1375956..1377923 /gene="mcpC" /locus_tag="BSU_13950" /old_locus_tag="BSU13950" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:9721285, 11722727, 12603740, 15317802, 23038252, 27899502" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9721285, 11722727, 12603740, 15317802, 23038252, 27899502; Product type rc : receptor" /codon_start=1 /transl_table=11 /product="methyl-accepting chemotaxis protein" /protein_id="NP_389278.2" /db_xref="EnsemblGenomes-Gn:BSU13950" /db_xref="EnsemblGenomes-Tr:CAB13268" /db_xref="GOA:P54576" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR033479" /db_xref="SubtiList:BG11533" /db_xref="UniProtKB/Swiss-Prot:P54576" /translation="MFKKLHMKIAVFVSIMLIITVVLLMLSSYLTLKPMITEDGKNTT QNVTQSLEQNIELQLKSYAISLSRLANGELTHTFVTKPSKEASRLFHDDIKQIKDNDD YVAMAYIGTAKKEMFTYPKADFAEDYDPTSRPWYKLAAETPDQVVWTEPYKDVVTGDM IVTASKAILDRQKVIGVASYDLKLSAIQSMVNKQKVPYKGFAFLADASGNLLAHPSNQ GKNISKDQTLQTIASEKKGIQDVNGKMVVYQTIGETGWKVGTQFDTDQLMWISDKMNR ANLWISLIALIITIILSYFLAKTITGPIQQLIVKTKAVSAGDLTVRAESKSKDEVGIL TRDFNLMVENMKEMVEQVRLSSGKVSDTSEQLTAVAAETNETSGQIAKAIEEVAAGAS EQASEVETINEKSESLSTKIRQIAEEAGGIKERSKSSEDASYKGLDALGQLLMKSNEA NMETKKVETMLLDLENQTKNIEEVVTAISNISDQTNLLALNASIEAARAGESGRGFAV VADEVRKLAEQSALSTKHISETVKLIQLETKEASHAMVEASRMNDEQNSAIHETGEVL NTITAEMQSLVQGIDHIYAEIQRMSEEQLAISEAIQSISAISQESAAAAEEVNASTDE QLVTLDKVKHSTETLKHASQELMNTIAKFTL*" /label="mcpC CDS" gene 1375956..1377923 /gene="mcpC" /locus_tag="BSU_13950" /old_locus_tag="BSU13950" /label="mcpC gene" misc_feature complement(1376396..1376411) /Source="Nicolas_upshift_promotors" /id="U1142" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.518481518481518" /psig="0.367632367632368" /xcortree=380 /SigmaFactorBS="cctgtctaagatcgctttcgatgcagtaacaatcatgtctcc tgtcacgacatctttATAAGGTTCCGTCCAAacaacttgatccggggtttcagctgca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1376408) /Source="Nicolas_upshifts" /id="U1142" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.518481518481518" /psig="0.367632367632368" /xcortree=380 /SigmaFactorBS="cctgtctaagatcgctttcgatgcagtaacaatcatgtctcc tgtcacgacatctttATAAGGTTCCGTCCAAacaacttgatccggggtttcagctgca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1377894 /Source="Nicolas_upshifts" /id="D776" /incds=0 /nref=134 /ntot=209 /MaxReadThrough="3.05506" /MaxDrop="5.75836" /score="24.6367658" /energy="-12.1" /TU="U1141" /idTUdmin="U1141" /TUdmin="-89" /isTUend="FALSE" /label="downshifts" promotor_-35 1377967..1377969 /Source="Nicolas_upshift_promotors" /id="U1143" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig=1 /xcortree=2290 /SigmaFactorBS="ccccaaacatcatttgttttggggattttttaTTTtataaga tgaatagaTATGGTAGTCTAGAAAATGAaggaaaaatgataaattttaactaaaatct a" /listShort="ykwC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1377985..1378004 /Source="Nicolas_upshift_promotors" /id="U1143" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig=1 /xcortree=2290 /SigmaFactorBS="ccccaaacatcatttgttttggggattttttaTTTtataaga tgaatagaTATGGTAGTCTAGAAAATGAaggaaaaatgataaattttaactaaaatct a" /listShort="ykwC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1377995 /Source="Nicolas_upshifts" /id="U1143" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig=1 /xcortree=2290 /SigmaFactorBS="ccccaaacatcatttgttttggggattttttaTTTtataaga tgaatagaTATGGTAGTCTAGAAAATGAaggaaaaatgataaattttaactaaaatct a" /listShort="ykwC" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(1378037) /Source="Nicolas_upshifts" /id="D777" /incds=0 /nref=1 /ntot=91 /MaxReadThrough="2.29647" /MaxDrop="4.49503" /score="37.1302416" /energy="-14.5" /TU="NA" /idTUdmin="U1144" /TUdmin=946 /isTUend="FALSE" /label="downshifts" CDS 1378061..1378927 /gene="ohaC" /locus_tag="BSU_13960" /old_locus_tag="BSU13960" /EC_number="1.1.1.60" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:20941576, 24390483" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20941576, 24390483; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="beta-hydroxyacid dehydrogenase (acts on 3-hydroxypropionate with NADP)" /protein_id="NP_389279.1" /db_xref="EnsemblGenomes-Gn:BSU13960" /db_xref="EnsemblGenomes-Tr:CAB13269" /db_xref="GOA:O34948" /db_xref="InterPro:IPR002204" /db_xref="InterPro:IPR006115" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR015815" /db_xref="InterPro:IPR029154" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13328" /db_xref="UniProtKB/Swiss-Prot:O34948" /translation="MKKTIGFIGLGVMGKSMASHILNDGHPVLVYTRTKEKAESILQK GAIWKDTVKDLSKEADVIITMVGYPSDVEEVYFGSNGIIENAKEGAYLIDMTTSKPSL AKKIAEAAKEKALFALDAPVSGGDIGAQNGTLAIMVGGEKEAFEACMPIFSLMGENIQ YQGPAGSGQHTKMCNQIAIAAGMIGVAEAMAYAQKSGLEPENVLKSITTGAAGSWSLS NLAPRMLQGNFEPGFYVKHFIKDMGIALEEAELMGEEMPGLSLAKSLYDKLAAQGEEN SGTQSIYKLWVK*" /label="ohaC CDS" gene 1378061..1378927 /gene="ohaC" /locus_tag="BSU_13960" /old_locus_tag="BSU13960" /label="ohaC gene" downshifts 1378907 /Source="Nicolas_upshifts" /id="D778" /incds=0 /nref=239 /ntot=266 /MaxReadThrough="2.14032" /MaxDrop="8.18847" /score="41.1703019" /energy="-14.5" /TU="NA" /idTUdmin="U1143" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1378966..1379739) /gene="ykwD" /locus_tag="BSU_13970" /old_locus_tag="BSU13970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389280.2" /db_xref="EnsemblGenomes-Gn:BSU13970" /db_xref="EnsemblGenomes-Tr:CAB13270" /db_xref="InterPro:IPR014044" /db_xref="InterPro:IPR014258" /db_xref="InterPro:IPR035940" /db_xref="SubtiList:BG13329" /db_xref="UniProtKB/Swiss-Prot:O31398" /translation="MKKAFILSAAAAVGLFTFGGVQQASAKELSCQPVVTVKTGNTVQ NMSLNDAVKKLHINTNIKTLNAANEKEMKQLLQKHAKQSNVKVQDVQKTETAKPAQKT TEKAAADQNTASKAPATAEKTNTTTSAPSSVSAYEKKVVELTNAERQKQGLKPLQIDE TLSKSARAKSQDMKDKNYFDHQSPTYGSPFDMMKSFGISYKTAGENIAKGQKTPEEVV KAWMNSEGHRKNILNPNFTHIGVGYVESGSIWTQQFIGK*" /label="ykwD CDS" gene complement(1378966..1379739) /gene="ykwD" /locus_tag="BSU_13970" /old_locus_tag="BSU13970" /label="ykwD gene" downshifts complement(1378983) /Source="Nicolas_upshifts" /id="D779" /incds=0 /nref=31 /ntot=168 /MaxReadThrough="1.32532" /MaxDrop="5.28625" /score="37.1302416" /energy="-14.5" /TU="NA" /idTUdmin="U1144" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(1379771..1379790) /Source="Nicolas_upshift_promotors" /id="U1144" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.711288711288711" /psig="0.994005994005994" /xcortree=2987 /SigmaFactorBS="acaatctctatttgtcaaaggaaagtgctggaatctttatga caaaaaagcTATGTTATGATTTTTCTGTAgaaacaaacaactctaggaggttacgaac t" /listShort="ykwD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1379781) /Source="Nicolas_upshifts" /id="U1144" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.711288711288711" /psig="0.994005994005994" /xcortree=2987 /SigmaFactorBS="acaatctctatttgtcaaaggaaagtgctggaatctttatga caaaaaagcTATGTTATGATTTTTCTGTAgaaacaaacaactctaggaggttacgaac t" /listShort="ykwD" /GFF_Attribute="listLong" /label="upshifts" misc_feature 1380014..1380033 /Source="Nicolas_upshift_promotors" /id="U1145" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.825174825174825" /psig="0.998001998001998" /xcortree=3175 /SigmaFactorBS="tattgacagctttttttactccttttcgctgtaacaactatt acaaaGGTGTTACAATTAATCTCAGtatatgtaaatatattgaatgatttgagagggg t" /listShort="S507, pbpH, kinA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1380027 /Source="Nicolas_upshifts" /id="U1145" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.825174825174825" /psig="0.998001998001998" /xcortree=3175 /SigmaFactorBS="tattgacagctttttttactccttttcgctgtaacaactatt acaaaGGTGTTACAATTAATCTCAGtatatgtaaatatattgaatgatttgagagggg t" /listShort="S507, pbpH, kinA" /GFF_Attribute="listLong" /label="upshifts" S_feature 1380029..1380132 /Source="Nicolas_S_feature" /locus_tag="new_1467701_1467804" /HighExp="T4.0H, T3.30H, T3.0H, Etha, T5.0H, T2.30H, LoTm, B60, T2.0H, LPhT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S507" CDS 1380076..1382190 /gene="pbpH" /locus_tag="BSU_13980" /old_locus_tag="BSU13980" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12896990, 23199363" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12896990, 23199363; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="penicillin-binding enzyme for formation of rod-shaped peptidoglycan cell wall" /protein_id="NP_389281.2" /db_xref="EnsemblGenomes-Gn:BSU13980" /db_xref="EnsemblGenomes-Tr:CAB13271" /db_xref="GOA:Q796K8" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR005311" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR036138" /db_xref="SubtiList:BG13286" /db_xref="UniProtKB/Swiss-Prot:Q796K8" /translation="MTEIGREPKKKSKGNRAIRMNLFFLAVFVLFTALIFKLGVVQIV EGEQHEEDAEKSNAKTAYYPAPRGKMYDRNQKVAVDNQSVPEIVYVSTSSTKTEDKIK TAKRLASFIHIDTEFLKERDLRDYWIAAHPKKAAALLKESESNLKGDQAYKLQIERVP DQELKAIQQDDEEMETAAIYTRFSSGNAYEPQIVKAMNPNKSNSNGKNGALLDEKKNS SQRPKNDLTYDEISIVSEHLEELPGIDIVNDWTRKYPYDKTLYSVFGGVTTPDQGLLS DRKDFYLTRGYANNDRVGKSYLEYQYEEYLNSHKEKVEYVEDNKGNVVSQKTIDKGSR GYDLQLSFDMELQAKVEKIIEEEVRNSRARGNYMLDRAFAVMMDPNNGDILSMAGKKI DLKTNKIEDYAIGAFTTQYEMGSAVKGATVLAGYQDGIPHYKYYIDAPMLLGTNLIKK SYTNMGTINELTALQKSSNVYMFNVAMHIAGVTYKPHGSLPADQNDLLKMRNYYSQFG LGVKTGIDLPQESAGMQTTPKTVGGLILDLAIGQYDTYTPLQMAQYISVIANGGYRVQ PRIVTSIHKPGKKDQLGKAIEHRKPKVLNKINNSESDLKQVQTGMKLVTSSGTAKNTF TEDVSGKTGTAETFYYGTNRNWWGKKTYNLTFVGYYPSKKPKVAFSVVVPSVDDDDKI NKIIAKRAIHAYAELEKKHSKK*" /label="pbpH CDS" gene 1380076..1382190 /gene="pbpH" /locus_tag="BSU_13980" /old_locus_tag="BSU13980" /label="pbpH gene" promotor_-10 complement(1381369..1381387) /Source="Nicolas_upshift_promotors" /id="U1146" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.836163836163836" /psig="0.836163836163836" /xcortree=778 /SigmaFactorBS="ccatattagtataagatttttttataagattcgTTCCTAaaa gcattggagcatCGATATAATATTTATAATGcgggatcccgtcctgatagccggctag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1381381) /Source="Nicolas_upshifts" /id="U1146" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.836163836163836" /psig="0.836163836163836" /xcortree=778 /SigmaFactorBS="ccatattagtataagatttttttataagattcgTTCCTAaaa gcattggagcatCGATATAATATTTATAATGcgggatcccgtcctgatagccggctag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1381403..1381408) /Source="Nicolas_upshift_promotors" /id="U1146" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.836163836163836" /psig="0.836163836163836" /xcortree=778 /SigmaFactorBS="ccatattagtataagatttttttataagattcgTTCCTAaaa gcattggagcatCGATATAATATTTATAATGcgggatcccgtcctgatagccggctag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1382171 /Source="Nicolas_upshifts" /id="D780" /incds=0 /nref=139 /ntot=246 /MaxReadThrough="3.36066" /MaxDrop="5.01597" /score="-1.2500858" /energy="-12" /TU="U1145" /idTUdmin="U1145" /TUdmin="-1862" /isTUend="FALSE" /label="downshifts" promotor_-35 1382263..1382271 /Source="Nicolas_upshift_promotors" /id="U1147" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=554 /SigmaFactorBS="tcaaaaattgacgttcaccataagaataGAAGGAGAAtactc attttcTAGCGAATCATACTAGGTAaaagtcaatctgtatatgtcgaaacacgatgat c" /listShort="kinA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1382283..1382301 /Source="Nicolas_upshift_promotors" /id="U1147" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=554 /SigmaFactorBS="tcaaaaattgacgttcaccataagaataGAAGGAGAAtactc attttcTAGCGAATCATACTAGGTAaaagtcaatctgtatatgtcgaaacacgatgat c" /listShort="kinA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1382295 /Source="Nicolas_upshifts" /id="U1147" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=554 /SigmaFactorBS="tcaaaaattgacgttcaccataagaataGAAGGAGAAtactc attttcTAGCGAATCATACTAGGTAaaagtcaatctgtatatgtcgaaacacgatgat c" /listShort="kinA" /GFF_Attribute="listLong" /label="upshifts" CDS 1382354..1384174 /gene="kinA" /locus_tag="BSU_13990" /old_locus_tag="BSU13990" /EC_number="2.7.13.3" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11734624, 14629015, 17350039, 21097618, 22303282, 23169620, 23378509, 23504013, 26712348, 28449380" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11734624, 14629015, 17350039, 21097618, 22303282, 23169620, 23378509, 23504013, 26712348, 28449380; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sporulation-specific ATP-dependent protein histidine kinase" /protein_id="NP_389282.1" /db_xref="EnsemblGenomes-Gn:BSU13990" /db_xref="EnsemblGenomes-Tr:CAB13272" /db_xref="GOA:P16497" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR001610" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR013655" /db_xref="InterPro:IPR013767" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="PDB:2VLG" /db_xref="SubtiList:BG10204" /db_xref="UniProtKB/Swiss-Prot:P16497" /translation="MEQDTQHVKPLQTKTDIHAVLASNGRIIYISANSKLHLGYLQGE MIGSFLKTFLHEEDQFLVESYFYNEHHLMPCTFRFIKKDHTIVWVEAAVEIVTTRAER TEREIILKMKVLEEETGHQSLNCEKHEIEPASPESTTYITDDYERLVENLPSPLCISV KGKIVYVNSAMLSMLGAKSKDAIIGKSSYEFIEEEYHDIVKNRIIRMQKGMEVGMIEQ TWKRLDGTPVHLEVKASPTVYKNQQAELLLLIDISSRKKFQTILQKSRERYQLLIQNS IDTIAVIHNGKWVFMNESGISLFEAATYEDLIGKNIYDQLHPCDHEDVKERIQNIAEQ KTESEIVKQSWFTFQNRVIYTEMVCIPTTFFGEAAVQVILRDISERKQTEELMLKSEK LSIAGQLAAGIAHEIRNPLTAIKGFLQLMKPTMEGNEHYFDIVFSELSRIELILSELL MLAKPQQNAVKEYLNLKKLIGEVSALLETQANLNGIFIRTSYEKDSIYINGDQNQLKQ VFINLIKNAVESMPDGGTVDIIITEDEHSVHVTVKDEGEGIPEKVLNRIGEPFLTTKE KGTGLGLMVTFNIIENHQGVIHVDSHPEKGTAFKISFPKK*" /label="kinA CDS" gene 1382354..1384174 /gene="kinA" /locus_tag="BSU_13990" /old_locus_tag="BSU13990" /label="kinA gene" CDS complement(1384185..1385366) /gene="dapX" /locus_tag="BSU_14000" /old_locus_tag="BSU14000" /EC_number="2.6.1.83" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12670965, 14523133, 14627808, 19948795" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12670965, 14523133, 14627808, 19948795; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetyl-L,L-diaminopimelate aminotransferase" /protein_id="NP_389283.2" /db_xref="EnsemblGenomes-Gn:BSU14000" /db_xref="EnsemblGenomes-Tr:CAB13273" /db_xref="GOA:P16524" /db_xref="InterPro:IPR004838" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG10205" /db_xref="UniProtKB/Swiss-Prot:P16524" /translation="MEHLLNPKAREIEISGIRKFSNLVAQHEDVISLTIGQPDFFTPH HVKAAAKKAIDENVTSYTPNAGYLELRQAVQLYMKKKADFNYDAESEIIITTGASQAI DAAFRTILSPGDEVIMPGPIYPGYEPIINLCGAKPVIVDTTSHGFKLTARLIEDALTP NTKCVVLPYPSNPTGVTLSEEELKSIAALLKGRNVFVLSDEIYSELTYDRPHYSIATY LRDQTIVINGLSKSHSMTGWRIGFLFAPKDIAKHILKVHQYNVSCASSISQKAALEAV TNGFDDALIMREQYKKRLDYVYDRLVSMGLDVVKPSGAFYIFPSIKSFGMTSFDFSMA LLEDAGVALVPGSSFSTYGEGYVRLSFACSMDTLREGLDRLELFVLKKREAMQTINNG V*" /label="dapX CDS" gene complement(1384185..1385366) /gene="dapX" /locus_tag="BSU_14000" /old_locus_tag="BSU14000" /label="dapX gene" downshifts complement(1384219) /Source="Nicolas_upshifts" /id="D781" /incds=0 /nref=255 /ntot=267 /MaxReadThrough="1.89632" /MaxDrop="6.70715" /score="-6.17975559" /energy="-4.7" /TU="NA" /idTUdmin="U1148" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(1385394..1385413) /Source="Nicolas_upshift_promotors" /id="U1148" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.928071928071928" /psig=1 /xcortree=1466 /SigmaFactorBS="gaaaaaaggcgcatacaatcgaaatatatcagttaaaaaggt gacaaatgatcagctAGTGGTAAAATAGGATAAACtcattatatttgttaaggtgatg a" /listShort="patA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1385410) /Source="Nicolas_upshifts" /id="U1148" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.928071928071928" /psig=1 /xcortree=1466 /SigmaFactorBS="gaaaaaaggcgcatacaatcgaaatatatcagttaaaaaggt gacaaatgatcagctAGTGGTAAAATAGGATAAACtcattatatttgttaaggtgatg a" /listShort="patA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1385442..1385460) /Source="Nicolas_upshift_promotors" /id="U1149" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1170 /SigmaFactorBS="atcgctggttgtcttctttttttctgaaaagaaaGGTATGtt tagaaaaaaggcGCATACAATCGAAATATATcagttaaaaaggtgacaaatgatcagc t" /listShort="patA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1385454) /Source="Nicolas_upshifts" /id="U1149" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1170 /SigmaFactorBS="atcgctggttgtcttctttttttctgaaaagaaaGGTATGtt tagaaaaaaggcGCATACAATCGAAATATATcagttaaaaaggtgacaaatgatcagc t" /listShort="patA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1385456..1385524) /Source="Nicolas_S_feature" /locus_tag="new_1473128_1473196_c" /HighExp="M9-stat, Lbtran, Lbstat, T3.30H, T3.0H, T2.30H, M0t90, T4.0H, M40t90, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S508" promotor_-35 complement(1385475..1385480) /Source="Nicolas_upshift_promotors" /id="U1149" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1170 /SigmaFactorBS="atcgctggttgtcttctttttttctgaaaagaaaGGTATGtt tagaaaaaaggcGCATACAATCGAAATATATcagttaaaaaggtgacaaatgatcagc t" /listShort="patA" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(1385518..1385537) /Source="Nicolas_upshift_promotors" /id="U1150" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=3165 /SigmaFactorBS="ttgattatggctattaatgaaattggcacatataaacaataa tagaaCATGATACAATAAAGACAATcaaatcgctggttgtcttctttttttctgaaaa g" /listShort="S508, patA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1385524) /Source="Nicolas_upshifts" /id="U1150" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=3165 /SigmaFactorBS="ttgattatggctattaatgaaattggcacatataaacaataa tagaaCATGATACAATAAAGACAATcaaatcgctggttgtcttctttttttctgaaaa g" /listShort="S508, patA" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1385568..1385729) /gene="ykzT" /locus_tag="BSU_14009" /old_locus_tag="BSU14009" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097722.1" /db_xref="EnsemblGenomes-Gn:BSU14009" /db_xref="EnsemblGenomes-Tr:CAX52613" /db_xref="UniProtKB/Swiss-Prot:C0H406" /translation="MGTLVIFKENEMTVLEDISEETYLNMKKESADLQEEHPPYLIWH EDLHFDYGY*" /label="ykzT CDS" gene complement(1385568..1385729) /gene="ykzT" /locus_tag="BSU_14009" /old_locus_tag="BSU14009" /label="ykzT gene" promotor_-10 complement(1385752..1385771) /Source="Nicolas_upshift_promotors" /id="U1151" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.702297702297702" /psig=1 /xcortree=2406 /SigmaFactorBS="gttcctcaaaaaagaaacttttttcctaataacCATTGACTt tccaactaacagTGATAAAATAGTCAAGGATTtttccaaagaagggtgtaaataatgg g" /listShort="ykzT, S508, patA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1385765) /Source="Nicolas_upshifts" /id="U1151" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.702297702297702" /psig=1 /xcortree=2406 /SigmaFactorBS="gttcctcaaaaaagaaacttttttcctaataacCATTGACTt tccaactaacagTGATAAAATAGTCAAGGATTtttccaaagaagggtgtaaataatgg g" /listShort="ykzT, S508, patA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1385785..1385792) /Source="Nicolas_upshift_promotors" /id="U1151" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.702297702297702" /psig=1 /xcortree=2406 /SigmaFactorBS="gttcctcaaaaaagaaacttttttcctaataacCATTGACTt tccaactaacagTGATAAAATAGTCAAGGATTtttccaaagaagggtgtaaataatgg g" /listShort="ykzT, S508, patA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1385866..1385873 /Source="Nicolas_upshift_promotors" /id="U1152" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2811 /SigmaFactorBS="cgcggcttgttgccttcggaattcgattttgaagagctgccA TTCACTTtttacaaattacGCCGATATATACAGTACAAtactgaatgcgaatagcgag g" /listShort="cheV" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1385885 /Source="Nicolas_upshifts" /id="U1152" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2811 /SigmaFactorBS="cgcggcttgttgccttcggaattcgattttgaagagctgccA TTCACTTtttacaaattacGCCGATATATACAGTACAAtactgaatgcgaatagcgag g" /listShort="cheV" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1385886..1385904 /Source="Nicolas_upshift_promotors" /id="U1152" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2811 /SigmaFactorBS="cgcggcttgttgccttcggaattcgattttgaagagctgccA TTCACTTtttacaaattacGCCGATATATACAGTACAAtactgaatgcgaatagcgag g" /listShort="cheV" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1385933..1386844 /gene="cheV" /locus_tag="BSU_14010" /old_locus_tag="BSU14010" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11553614, 12864845, 14731274, 14993307, 26844549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11553614, 12864845, 14731274, 14993307, 26844549; Product type r: regulator" /codon_start=1 /transl_table=11 /product="coupling protein and response regulator for CheAactivity in response to attractants (chemotaxis)" /protein_id="NP_389284.1" /db_xref="EnsemblGenomes-Gn:BSU14010" /db_xref="EnsemblGenomes-Tr:CAB13274" /db_xref="GOA:P37599" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR002545" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR024181" /db_xref="InterPro:IPR036061" /db_xref="SubtiList:BG10823" /db_xref="UniProtKB/Swiss-Prot:P37599" /translation="MSLQQYEILLDSGTNELEIVKFGVGENAFGINVMKVREIIQPVE VTSVPHSHQHVEGMIKLRGEILPVISLFSFFGVEPEGSKDEKYIVTEFNKRKIVFHVG SVSQIHRVSWEAIEKPTSLNQGMERHLTGIIKLEDLMIFLPDYEKIIYDIESDSGVDT YNMHTEGFDERRTDKKLIIVEDSPLLMRLLQDELKEAGYNNIASFENGKEAYEYIMNL AENETDLSKQIDMIITDIEMPKMDGHRLTKLLKENPKSSDVPVMIFSSLITDDLRHRG EVVGADEQISKPEISDLIKKVDTYVIE*" /label="cheV CDS" gene 1385933..1386844 /gene="cheV" /locus_tag="BSU_14010" /old_locus_tag="BSU14010" /label="cheV gene" downshifts complement(1385938) /Source="Nicolas_upshifts" /id="D782" /incds=0 /nref=1 /ntot=50 /MaxReadThrough="1.14523" /MaxDrop="3.62759" /score="-8.29055697" /energy="-7.7" /TU="NA" /idTUdmin="U1154" /TUdmin=968 /isTUend="FALSE" /label="downshifts" promotor_-35 1386387..1386395 /Source="Nicolas_upshift_promotors" /id="U1153" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.54045954045954" /psig="0.54045954045954" /xcortree=750 /SigmaFactorBS="ctttttgcctgactatgaaaaaattatttatgacaTTGAATC AGattcaggtgttgaCACGTATAATATGCATACcgagggcttcgatgaaagaagaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1386409..1386426 /Source="Nicolas_upshift_promotors" /id="U1153" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.54045954045954" /psig="0.54045954045954" /xcortree=750 /SigmaFactorBS="ctttttgcctgactatgaaaaaattatttatgacaTTGAATC AGattcaggtgttgaCACGTATAATATGCATACcgagggcttcgatgaaagaagaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1386412 /Source="Nicolas_upshifts" /id="U1153" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.54045954045954" /psig="0.54045954045954" /xcortree=750 /SigmaFactorBS="ctttttgcctgactatgaaaaaattatttatgacaTTGAATC AGattcaggtgttgaCACGTATAATATGCATACcgagggcttcgatgaaagaagaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1386829 /Source="Nicolas_upshifts" /id="D783" /incds=0 /nref=188 /ntot=251 /MaxReadThrough="4.61331" /MaxDrop="6.23797" /score="15.4598573" /energy="-13.1" /TU="U1152" /idTUdmin="U1153" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1386888..1387352) /gene="kre" /locus_tag="BSU_14020" /old_locus_tag="BSU14020" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of transcription factor ComK function via modulation of mRNA stability" /protein_id="NP_389285.1" /db_xref="EnsemblGenomes-Gn:BSU14020" /db_xref="EnsemblGenomes-Tr:CAB13275" /db_xref="InterPro:IPR025552" /db_xref="SubtiList:BG11202" /db_xref="UniProtKB/Swiss-Prot:P42430" /translation="MDDHAYTKDLQPTVENLSKAVYTVNRHAKTAPNPKYLYLLKKRA LQKLVKEGKGKKIGLHFSKNPRFSQQQSDVLISIGDYYFHMPPTKEDFEHLPHLGTLN QSYRNPKAQMSLTKAKHLLQEYVGMKEKPLVPNRQQPAYHKPVFKKLGESYF*" /label="kre CDS" gene complement(1386888..1387352) /gene="kre" /locus_tag="BSU_14020" /old_locus_tag="BSU14020" /label="kre gene" downshifts complement(1386906) /Source="Nicolas_upshifts" /id="D784" /incds=0 /nref=212 /ntot=260 /MaxReadThrough="2.67186" /MaxDrop="6.66359" /score="16.1985615" /energy="-13.1" /TU="NA" /idTUdmin="U1154" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1387382..1387401) /Source="Nicolas_upshift_promotors" /id="U1154" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.878121878121878" /psig="0.99100899100899" /xcortree=2996 /SigmaFactorBS="cttagaaaaaagcgcatttttacattcaaTATTTGCAtttca actttaaaaAAGTATAATCTAAACATATAgaaattgataagagcaaaggagagaaata a" /listShort="ykyB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1387392) /Source="Nicolas_upshifts" /id="U1154" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.878121878121878" /psig="0.99100899100899" /xcortree=2996 /SigmaFactorBS="cttagaaaaaagcgcatttttacattcaaTATTTGCAtttca actttaaaaAAGTATAATCTAAACATATAgaaattgataagagcaaaggagagaaata a" /listShort="ykyB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1387416..1387423) /Source="Nicolas_upshift_promotors" /id="U1154" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.878121878121878" /psig="0.99100899100899" /xcortree=2996 /SigmaFactorBS="cttagaaaaaagcgcatttttacattcaaTATTTGCAtttca actttaaaaAAGTATAATCTAAACATATAgaaattgataagagcaaaggagagaaata a" /listShort="ykyB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1387478..1388770) /gene="ykuC" /locus_tag="BSU_14030" /old_locus_tag="BSU14030" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_389286.2" /db_xref="EnsemblGenomes-Gn:BSU14030" /db_xref="EnsemblGenomes-Tr:CAB13276" /db_xref="GOA:O31695" /db_xref="InterPro:IPR004751" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13287" /db_xref="UniProtKB/Swiss-Prot:O31695" /translation="MDIFKNRNFVRLFFAALASQMGTTVGNMAFAFFLLDRFSSQPSY TTLAELMYSLPTIFVFLIVGVVADRFDRKKVAENCDWIRAGLTVVLFFTLFTGNIPLV FCILFIRSAVTKFFFPAENSLVQAILPKEHYAKAAGLNQMLFSIFMVFGVGIGAFMYN TIGIEGAIILDFVSFIISGLLIRSCRIPKEARQPNGAFSWRKTSVKDSINDFREGILY ILKNKLLASLIFGFFIFGFVNGGFAVLPMFTMKYGLAPDRYEWHTSVFTIALGFGLLA GSVIGTLISKKVKPHFLMSIPIFIAGLLIFVLGYTNILWVYYAAAFALGMCIGPINIA IGGWMPKIVHPKLMGRVSGMQDPFMMFAQSLTLGLVALLFPKFVSNIDYLYYGMGVII LLVFIFYFIALPKYSAQAVEVNVQEAFQEQPKKKARSV*" /label="ykuC CDS" gene complement(1387478..1388770) /gene="ykuC" /locus_tag="BSU_14030" /old_locus_tag="BSU14030" /label="ykuC gene" downshifts complement(1387500) /Source="Nicolas_upshifts" /id="D785" /incds=0 /nref=37 /ntot=206 /MaxReadThrough="4.24449" /MaxDrop="4.31411" /score="3.5676583" /energy="-14.2" /TU="U1155" /idTUdmin="U1156" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1388794..1388813) /Source="Nicolas_upshift_promotors" /id="U1155" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.831168831168831" /psig="0.997002997002997" /xcortree=1817 /SigmaFactorBS="gattaaccggtaatgttttcttattTGTTTcaaaaacaggcg gttTATAATATGATAAAGTGGGAcctttagggtaaggagcgtttttatggatatattt a" /listShort="ykuC" /listLong="ykyB" /label="promotor_-10" upshifts complement(1388798) /Source="Nicolas_upshifts" /id="U1155" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.831168831168831" /psig="0.997002997002997" /xcortree=1817 /SigmaFactorBS="gattaaccggtaatgttttcttattTGTTTcaaaaacaggcg gttTATAATATGATAAAGTGGGAcctttagggtaaggagcgtttttatggatatattt a" /listShort="ykuC" /listLong="ykyB" /label="upshifts" promotor_-35 complement(1388829..1388833) /Source="Nicolas_upshift_promotors" /id="U1155" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.831168831168831" /psig="0.997002997002997" /xcortree=1817 /SigmaFactorBS="gattaaccggtaatgttttcttattTGTTTcaaaaacaggcg gttTATAATATGATAAAGTGGGAcctttagggtaaggagcgtttttatggatatattt a" /listShort="ykuC" /listLong="ykyB" /label="promotor_-35" CDS complement(1388846..1389340) /gene="ltdD" /locus_tag="BSU_14040" /old_locus_tag="BSU14040" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:11011148, 16287140, 23832002" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11011148, 16287140, 23832002; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="murein L,D-transpeptidase" /protein_id="NP_389287.1" /db_xref="EnsemblGenomes-Gn:BSU14040" /db_xref="EnsemblGenomes-Tr:CAB13277" /db_xref="GOA:O34816" /db_xref="InterPro:IPR005490" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="PDB:1Y7M" /db_xref="PDB:2MTZ" /db_xref="PDB:3ZQD" /db_xref="PDB:4A1I" /db_xref="PDB:4A1J" /db_xref="PDB:4A1K" /db_xref="PDB:4A52" /db_xref="SubtiList:BG13288" /db_xref="UniProtKB/Swiss-Prot:O34816" /translation="MLTYQVKQGDTLNSIAADFRISTAALLQANPSLQAGLTAGQSIV IPGLPDPYTIPYHIAVSIGAKTLTLSLNNRVMKTYPIAVGKILTQTPTGEFYIINRQR NPGGPFGAYWLSLSKQHYGIHGTNNPASIGKAVSKGCIRMHNKDVIELASIVPNGTRV TINR*" /label="ltdD CDS" gene complement(1388846..1389340) /gene="ltdD" /locus_tag="BSU_14040" /old_locus_tag="BSU14040" /label="ltdD gene" promotor_-10 complement(1389356..1389375) /Source="Nicolas_upshift_promotors" /id="U1156" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1309 /SigmaFactorBS="gaaatcactgtcttcaccttaaaaagcacaaattAATGTAGC AGgatgggctcctcaTCAATACTTATAAGTAAAAAaggaggatgaggaaactgcttac g" /listShort="ykuD, ykuC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1389372) /Source="Nicolas_upshifts" /id="U1156" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1309 /SigmaFactorBS="gaaatcactgtcttcaccttaaaaagcacaaattAATGTAGC AGgatgggctcctcaTCAATACTTATAAGTAAAAAaggaggatgaggaaactgcttac g" /listShort="ykuD, ykuC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1389389..1389398) /Source="Nicolas_upshift_promotors" /id="U1156" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1309 /SigmaFactorBS="gaaatcactgtcttcaccttaaaaagcacaaattAATGTAGC AGgatgggctcctcaTCAATACTTATAAGTAAAAAaggaggatgaggaaactgcttac g" /listShort="ykuD, ykuC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1389397..1390257) /gene="ppeE" /locus_tag="BSU_14050" /old_locus_tag="BSU14050" /EC_number="3.1.-.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:22767609, 24140208" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22767609, 24140208; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exported metallophosphoesterase (Mn2+ and Zn2+)" /protein_id="NP_389288.2" /db_xref="EnsemblGenomes-Gn:BSU14050" /db_xref="EnsemblGenomes-Tr:CAB13278" /db_xref="GOA:O34870" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR006311" /db_xref="InterPro:IPR019546" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG13289" /db_xref="UniProtKB/Swiss-Prot:O34870" /translation="MKKMSRRQFLKGMFGALAAGALTAGGGYGYARYLEPHMIETTEH TIKSSLIPHGFDGFKIVQFSDAHLSDYFTLEDLKTVILTINESKPDLIVFTGDIIDNP DTYQHHQAVIPLLRKLNAPFGKLCIYGNHDHGGYGTAVYKSLMTAGGFTVYRNGYQTL SLADGSKIEIASLDDLMLGNPDYEGTLSRLSDRLFSILLVHEPDAALKTTDYPVNLQL SGHTHGGQIQLPFYGPIITPPYGKVYTEGMYQTGSTHIYVNRGLGMTRLPLRFLAKPE ITVFTLKSTN*" /label="ppeE CDS" gene complement(1389397..1390257) /gene="ppeE" /locus_tag="BSU_14050" /old_locus_tag="BSU14050" /label="ppeE gene" misc_feature complement(1390278..1390297) /Source="Nicolas_upshift_promotors" /id="U1157" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.885114885114885" /psig="0.997002997002997" /xcortree=1947 /SigmaFactorBS="attatatccctgcctctgtcagcacatgctcatatgagattt ttatcagatacaGATGATATAATAGAAAAACTctattaaaggttggtttgaaatgaaa a" /listShort="ykuE, ykuD" /listLong="ykuC, ykyB" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1390291) /Source="Nicolas_upshifts" /id="U1157" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.885114885114885" /psig="0.997002997002997" /xcortree=1947 /SigmaFactorBS="attatatccctgcctctgtcagcacatgctcatatgagattt ttatcagatacaGATGATATAATAGAAAAACTctattaaaggttggtttgaaatgaaa a" /listShort="ykuE, ykuD" /listLong="ykuC, ykyB" /label="upshifts" promotor_-35 1390328..1390335 /Source="Nicolas_upshift_promotors" /id="U1158" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.781218781218781" /psig="0.97002997002997" /xcortree=404 /SigmaFactorBS="tgataaaaatctcatatgagcatgTGCTGACAgaggcaggga tataaTGATAGAATATTATTGAATGaataatcattcacaattggagggataaacatgg a" /listShort="fadH, S509, S510, fadG, ykzU, ykuH" /listLong="S511, ykuI" /label="promotor_-35" promotor_-10 1390351..1390370 /Source="Nicolas_upshift_promotors" /id="U1158" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.781218781218781" /psig="0.97002997002997" /xcortree=404 /SigmaFactorBS="tgataaaaatctcatatgagcatgTGCTGACAgaggcaggga tataaTGATAGAATATTATTGAATGaataatcattcacaattggagggataaacatgg a" /listShort="fadH, S509, S510, fadG, ykzU, ykuH" /listLong="S511, ykuI" /label="promotor_-10" upshifts 1390364 /Source="Nicolas_upshifts" /id="U1158" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.781218781218781" /psig="0.97002997002997" /xcortree=404 /SigmaFactorBS="tgataaaaatctcatatgagcatgTGCTGACAgaggcaggga tataaTGATAGAATATTATTGAATGaataatcattcacaattggagggataaacatgg a" /listShort="fadH, S509, S510, fadG, ykzU, ykuH" /listLong="S511, ykuI" /label="upshifts" CDS 1390400..1391164 /gene="fadH" /locus_tag="BSU_14060" /old_locus_tag="BSU14060" /EC_number="1.3.1.34" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17189250, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 2,4-dienoyl-CoA reductase" /protein_id="NP_389289.1" /db_xref="EnsemblGenomes-Gn:BSU14060" /db_xref="EnsemblGenomes-Tr:CAB13279" /db_xref="GOA:O34717" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13290" /db_xref="UniProtKB/Swiss-Prot:O34717" /translation="MEKKAVIITGGSSGMGKAMAKKQAELGWHVMVTGRNHEALEETK KEIQTFEGQVACFQMDVRSDSAASDMIKEAVKAFGRLDALINNAAGNFICPAEKLTPN GWKAVIEIVLNGTFFCSQAAARHWIDQKQQGVILNMAATYAWGAGAGVVHSAAAKAGV LSLTRTLAVEWGSKYGIRTNAIAPGPIERTGGAEKLFESEKAMARTMNSVPLGRLGTP EEIAALAAFLLSDEASYINGDCITMDGGQWLNPYPF*" /label="fadH CDS" gene 1390400..1391164 /gene="fadH" /locus_tag="BSU_14060" /old_locus_tag="BSU14060" /label="fadH gene" S_feature 1391165..1391313 /Source="Nicolas_S_feature" /locus_tag="new_1478837_1478985" /HighExp="T0.30H, T1.0H, B60, Sw, BC, LoTm, M9-stat, S8, S7, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.97" /TUlongSig="NA" /TUlongPSig="NA" /label="S509" misc_feature 1391294..1391312 /Source="Nicolas_upshift_promotors" /id="U1159" /multdbtbs="-" /comp="M12" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=1521 /SigmaFactorBS="tgataacacatagagctttatttgtttatgaggtgttgtGTC ATACGTAAGCCACCTAatatatgaaaggtatattttaaaaggggagacgaaatatgaa g" /listShort="S510, fadG, ykzU, ykuH, S511, ykuI, S512" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 1391315..1391464 /Source="Nicolas_S_feature" /locus_tag="new_1478987_1479136" /HighExp="T0.30H, M40t90, T1.0H, B60, BC, Sw, LPh, LoTm, M9-stat, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0, 0.97" /TUlongSig="NA" /TUlongPSig="NA" /label="S510" upshifts 1391315 /Source="Nicolas_upshifts" /id="U1159" /multdbtbs="-" /comp="M12" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=1521 /SigmaFactorBS="tgataacacatagagctttatttgtttatgaggtgttgtGTC ATACGTAAGCCACCTAatatatgaaaggtatattttaaaaggggagacgaaatatgaa g" /listShort="S510, fadG, ykzU, ykuH, S511, ykuI, S512" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(1391362) /Source="Nicolas_upshifts" /id="D786" /incds=0 /nref=3 /ntot=49 /MaxReadThrough="1.82681" /MaxDrop="3.39884" /score="-0.170855674" /energy="-4.8" /TU="NA" /idTUdmin="U1157" /TUdmin="-2542" /isTUend="FALSE" /label="downshifts" CDS 1391465..1393195 /gene="ykuG" /locus_tag="BSU_14071" /old_locus_tag="BSU14071" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17189250; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative cell wall-binding protein" /protein_id="YP_003097723.1" /db_xref="EnsemblGenomes-Gn:BSU14071" /db_xref="EnsemblGenomes-Tr:CAX52614" /db_xref="InterPro:IPR002477" /db_xref="InterPro:IPR015020" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR036365" /db_xref="InterPro:IPR036366" /db_xref="UniProtKB/Swiss-Prot:O34320" /translation="MDEMVLLTQEWLNETYKGKSGYNSIEENGKTGWKTMYALTRALQ LELGITQTSDSFGPTTLRKLKELGPISTSTNSKKNIVKIIQGALYCKGYGPGGLTGTF GQGTKEAIAEMQLHMGLSKTDGVVTPKVFKALLNMDSYILLNGASEKVRSIQQWLNNK YYNRENFYFMPCDGLYSRDTQKSLVYAIQYEEGLSDSIANGNFGPTTQRLIPVLRIGE TDEKNSFIHLFQAALIFNGYNVPFDGVYSESVRSKVKAFQSFAKLQQSGTADFQTWAS LLVSTGDPNRKGVACDSITQITSDRAESLKRAGYKIVGRYLTNAPGSTLNKKIQPGEL ETILKSGLNVFPIYQTYGGATNYFNKEQGKKDAFAAYKAAKEYGFKNNTVIYFAVDYD AYGNDLNNNIIPHFEGINEIMNGFLGSTYKIGIYAPRNVCTIVSKKGLAFASFVSGMS TGFSGNLGYPLPYNWAFDQISTITVGNGSGMIEIDNDICSGLDNGVNTINIVPSENKK FFDQIDVLYETAEKYAQMQSDLNNGVKKTQLANELVAQYLRKDDYKGWKWVPTAGQID PIYREWAVKR*" /label="ykuG CDS" gene 1391465..1393195 /gene="ykuG" /locus_tag="BSU_14071" /old_locus_tag="BSU14071" /label="ykuG gene" CDS 1393261..1393779 /gene="ykzU" /locus_tag="BSU_14072" /old_locus_tag="BSU14072" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097724.1" /db_xref="EnsemblGenomes-Gn:BSU14072" /db_xref="EnsemblGenomes-Tr:CAX52615" /db_xref="UniProtKB/Swiss-Prot:C0H408" /translation="MATYNAIIYSGGYSQTLRDFAGWTGDLLTTIQDMKLHAQEFNSP YDAAMKIIGNMYQFSLDDLFSDVDAINLANKTSVGANAQPLNIAIRDYYSNNDCMNRF TQFVNNRFDGSLDKIFSEAEYYLNTNLDPVVVPIRLAFKRAFDVEDYSEEIGKITAQA FRDVIEKKMISE*" /label="ykzU CDS" gene 1393261..1393779 /gene="ykzU" /locus_tag="BSU_14072" /old_locus_tag="BSU14072" /label="ykzU gene" downshifts 1393777 /Source="Nicolas_upshifts" /id="D787" /incds=0 /nref=1 /ntot=11 /MaxReadThrough="5.57306" /MaxDrop="3.8585" /score="8.20824413" /energy="-13" /TU="U1158,U1159" /idTUdmin="U1158" /TUdmin="-682" /isTUend="FALSE" /label="downshifts" promotor_-35 1393822..1393827 /Source="Nicolas_upshift_promotors" /id="U1160" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2279 /SigmaFactorBS="gcaaaacaagcgaacgttaaaactggtcgttcgcttgttTTA TTTtctatttaaattTATGATATAATTTTTAAAGAttaaggagtgattcattgaagaa a" /listShort="ykuH, S511, ykuI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1393840..1393859 /Source="Nicolas_upshift_promotors" /id="U1160" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2279 /SigmaFactorBS="gcaaaacaagcgaacgttaaaactggtcgttcgcttgttTTA TTTtctatttaaattTATGATATAATTTTTAAAGAttaaggagtgattcattgaagaa a" /listShort="ykuH, S511, ykuI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1393843 /Source="Nicolas_upshifts" /id="U1160" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2279 /SigmaFactorBS="gcaaaacaagcgaacgttaaaactggtcgttcgcttgttTTA TTTtctatttaaattTATGATATAATTTTTAAAGAttaaggagtgattcattgaagaa a" /listShort="ykuH, S511, ykuI" /GFF_Attribute="listLong" /label="upshifts" CDS 1393875..1394423 /gene="ykuH" /locus_tag="BSU_14080" /old_locus_tag="BSU14080" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389291.1" /db_xref="EnsemblGenomes-Gn:BSU14080" /db_xref="EnsemblGenomes-Tr:CAB13281" /db_xref="GOA:O31696" /db_xref="SubtiList:BG13292" /db_xref="UniProtKB/Swiss-Prot:O31696" /translation="MKKLLKKLVVLFLSSLVIIFNVWYFIICAFSPEYYQNTNLTSNE IIRFEKLYHIDFPDETKFIKAREYLAGPGGDTSAVLYVSLPTKRVEKVLSDYTYMKIN YTDNVGSMYGVDVSKSVAGLTTLTFGTYDKKGTFYNMKHDDDWMYKGTDWNLYFWTAA SYNAVIFVFVLVIVKQMNKILN*" /label="ykuH CDS" gene 1393875..1394423 /gene="ykuH" /locus_tag="BSU_14080" /old_locus_tag="BSU14080" /label="ykuH gene" S_feature 1394424..1394575 /Source="Nicolas_S_feature" /locus_tag="new_1482096_1482247" /HighExp="HiOs, LPhT, Salt, T0.0H, HiTm, T-0.40H, Fru, T-1.10H, LPh, T-4.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="1, 0" /TUlongSig="SigA" /TUlongPSig="0.97" /label="S511" CDS 1394576..1395799 /gene="ykuI" /locus_tag="BSU_14090" /old_locus_tag="BSU14090" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 19244251, 28536559; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="putative cyclic-di-GMP receptor (no phosphodiesterase activity)" /protein_id="NP_389292.1" /db_xref="EnsemblGenomes-Gn:BSU14090" /db_xref="EnsemblGenomes-Tr:CAB13282" /db_xref="InterPro:IPR001633" /db_xref="InterPro:IPR018842" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR035919" /db_xref="PDB:2BAS" /db_xref="PDB:2W27" /db_xref="SubtiList:BG13293" /db_xref="UniProtKB/Swiss-Prot:O35014" /translation="MLDPLDILTNIDDVLPYYQAIFSAEEQKVVGYEVLGRILADSEI QSLGPFFLDAGIPEEYKLEVDNRIIRQALDRFLEADSDLLIFMNQDANLLMLDHGESF LELLKEYEAKGIELHRFVLEITEHNFEGDIEQLYHMLAYYRTYGIKIAVDNIGKESSN LDRIALLSPDLLKIDLQALKVSQPSPSYEHVLYSISLLARKIGAALLYEDIEANFQLQ YAWRNGGRYFQGYYLVSPSETFLERDVLKQRLKTEFHQFITHEKKKLETVYEHSEQFY KRVHQAVTSLRKNNLSSDDDFIKKLAEELTDCSFRIYMCDEEGDQLTGNVFKQDGEWI YQPEYAEKNWSWRPYFLENIMRMRNLRKGFFSDLYSDLETGEMIRTFSYPMDDQMYLF IDLPYSYLYEQDGLI*" /label="ykuI CDS" gene 1394576..1395799 /gene="ykuI" /locus_tag="BSU_14090" /old_locus_tag="BSU14090" /label="ykuI gene" promotor_-10 complement(1395762..1395780) /Source="Nicolas_upshift_promotors" /id="U1161" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1186 /SigmaFactorBS="tttcatttcataaaaaaaacggcctttcagccGTTAAAtcag tccgtcctgcTCATATAAATAAGAATAAGgcaagtctataaataaatacatctgatca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1395772) /Source="Nicolas_upshifts" /id="U1161" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1186 /SigmaFactorBS="tttcatttcataaaaaaaacggcctttcagccGTTAAAtcag tccgtcctgcTCATATAAATAAGAATAAGgcaagtctataaataaatacatctgatca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1395778 /Source="Nicolas_upshifts" /id="D788" /incds=0 /nref=132 /ntot=229 /MaxReadThrough="3.48305" /MaxDrop="4.61382" /score="32.6727777" /energy="-7.5" /TU="U1159" /idTUdmin="U1160" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 complement(1395795..1395800) /Source="Nicolas_upshift_promotors" /id="U1161" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1186 /SigmaFactorBS="tttcatttcataaaaaaaacggcctttcagccGTTAAAtcag tccgtcctgcTCATATAAATAAGAATAAGgcaagtctataaataaatacatctgatca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1395848..1395855 /Source="Nicolas_upshift_promotors" /id="U1162" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2096 /SigmaFactorBS="aaggccgttttttttatgaaatgaaaaaaatatcaaaaaacG ATTGACAttgatactgagaatCATTATCATTTAATTATAGAgagaagctactctctgt t" /listShort="S512, S513, S514, ykuJ, S515, ykuK, ykzF" /listLong="S516, ykuL, S517, ccpC" /label="promotor_-35" S_feature 1395867..1395968 /Source="Nicolas_S_feature" /locus_tag="new_1483539_1483640" /HighExp="B36, B60, nit, Pyr, BI, HiOs, T-0.40H, S5, GM 15, S4" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="1, 0" /TUlongSig="NA" /TUlongPSig="NA" /label="S512" upshifts 1395867 /Source="Nicolas_upshifts" /id="U1162" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2096 /SigmaFactorBS="aaggccgttttttttatgaaatgaaaaaaatatcaaaaaacG ATTGACAttgatactgagaatCATTATCATTTAATTATAGAgagaagctactctctgt t" /listShort="S512, S513, S514, ykuJ, S515, ykuK, ykzF" /listLong="S516, ykuL, S517, ccpC" /label="upshifts" promotor_-10 1395870..1395889 /Source="Nicolas_upshift_promotors" /id="U1162" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2096 /SigmaFactorBS="aaggccgttttttttatgaaatgaaaaaaatatcaaaaaacG ATTGACAttgatactgagaatCATTATCATTTAATTATAGAgagaagctactctctgt t" /listShort="S512, S513, S514, ykuJ, S515, ykuK, ykzF" /listLong="S516, ykuL, S517, ccpC" /label="promotor_-10" misc_RNA 1395885..1395968 /gene="fsrA" /locus_tag="BSU_misc_RNA_69" /product="regulatory RNA controlling iron-dependent metabolism" /experiment="publication(s) with functional evidences, PMID:18697947, 22389480, 22427629, 24576839" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18697947, 22389480, 22427629, 24576839; Product type n: RNA" /function="12: Regulatory functions" /label="fsrA RNA" gene 1395885..1395968 /gene="fsrA" /locus_tag="BSU_misc_RNA_69" /label="fsrA gene" downshifts 1395925 /Source="Nicolas_upshifts" /id="D789" /incds=0 /nref=61 /ntot=192 /MaxReadThrough="6.41968" /MaxDrop="7.54463" /score="16.5898261" /energy="-8.8" /TU="U1159,U1162" /idTUdmin="U1159" /TUdmin="-74" /isTUend="FALSE" /label="downshifts" promotor_-35 1395979..1395984 /Source="Nicolas_upshift_promotors" /id="U1163" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1032 /SigmaFactorBS="aaaacttggcgctacccccgccaagttttttatttgtcaaAG CATAggacaatccaatgaaaCAATAAACCTAACTAGTGGtaaacgtttaacacgggga g" /listShort="S513, S514, ykuJ, S515, ykuK" /listLong="ykzF, S516, ykuL, S517, ccpC" /label="promotor_-35" S_feature 1395999..1396283 /Source="Nicolas_S_feature" /locus_tag="new_1483671_1483955" /HighExp="S4, H2O2, S5, Paraq, B60, nit, GM 10, B36, GM 25, GM 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.147452" /TUshortSig="SigEF, SigA" /TUshortPSig="0.997, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S513" upshifts 1395999 /Source="Nicolas_upshifts" /id="U1163" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1032 /SigmaFactorBS="aaaacttggcgctacccccgccaagttttttatttgtcaaAG CATAggacaatccaatgaaaCAATAAACCTAACTAGTGGtaaacgtttaacacgggga g" /listShort="S513, S514, ykuJ, S515, ykuK" /listLong="ykzF, S516, ykuL, S517, ccpC" /label="upshifts" promotor_-10 1396001..1396019 /Source="Nicolas_upshift_promotors" /id="U1163" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1032 /SigmaFactorBS="aaaacttggcgctacccccgccaagttttttatttgtcaaAG CATAggacaatccaatgaaaCAATAAACCTAACTAGTGGtaaacgtttaacacgggga g" /listShort="S513, S514, ykuJ, S515, ykuK" /listLong="ykzF, S516, ykuL, S517, ccpC" /label="promotor_-10" promotor_-35 1396260..1396266 /Source="Nicolas_upshift_promotors" /id="U1164" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=786 /SigmaFactorBS="atgctgccaaagattcgaaaaaaattataattatgTGCATGA cattcaaaaaaagCCTCAAACTAAAgaaaaatagtttttttcactttttttctttgct t" /listShort="S514, ykuJ, S515, ykuK, ykzF" /listLong="S516, ykuL, S517, ccpC" /label="promotor_-35" promotor_-10 1396280..1396291 /Source="Nicolas_upshift_promotors" /id="U1164" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=786 /SigmaFactorBS="atgctgccaaagattcgaaaaaaattataattatgTGCATGA cattcaaaaaaagCCTCAAACTAAAgaaaaatagtttttttcactttttttctttgct t" /listShort="S514, ykuJ, S515, ykuK, ykzF" /listLong="S516, ykuL, S517, ccpC" /label="promotor_-10" S_feature 1396285..1396372 /Source="Nicolas_S_feature" /locus_tag="new_1483957_1484044" /HighExp="S5, S4, H2O2, B60, Paraq, nit, B36, GM 10, S7, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigEF, SigA" /TUshortPSig="0.999, 0.997, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S514" upshifts 1396285 /Source="Nicolas_upshifts" /id="U1164" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=786 /SigmaFactorBS="atgctgccaaagattcgaaaaaaattataattatgTGCATGA cattcaaaaaaagCCTCAAACTAAAgaaaaatagtttttttcactttttttctttgct t" /listShort="S514, ykuJ, S515, ykuK, ykzF" /listLong="S516, ykuL, S517, ccpC" /label="upshifts" misc_feature 1396361..1396380 /Source="Nicolas_upshift_promotors" /id="U1165" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.48951048951049" /psig=1 /xcortree=2552 /SigmaFactorBS="ttttctttgcttaaattcagcagtgaaaatgccatcctgtcc gacttTATGGTATGATGCTCAATAGaacttgtattataataaatacttgttgatttga a" /listShort="ykuJ, S515, ykuK, ykzF, S516, ykuL, S517, ccpC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1396374 /Source="Nicolas_upshifts" /id="U1165" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.48951048951049" /psig=1 /xcortree=2552 /SigmaFactorBS="ttttctttgcttaaattcagcagtgaaaatgccatcctgtcc gacttTATGGTATGATGCTCAATAGaacttgtattataataaatacttgttgatttga a" /listShort="ykuJ, S515, ykuK, ykzF, S516, ykuL, S517, ccpC" /GFF_Attribute="listLong" /label="upshifts" CDS 1396445..1396684 /gene="ykuJ" /locus_tag="BSU_14100" /old_locus_tag="BSU14100" /function="10.3: tRNA and rRNA base modification" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16387657, 18436958; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA-specific modification enzyme subunit" /protein_id="NP_389293.1" /db_xref="EnsemblGenomes-Gn:BSU14100" /db_xref="EnsemblGenomes-Tr:CAB13283" /db_xref="InterPro:IPR014904" /db_xref="PDB:2FFG" /db_xref="SubtiList:BG13294" /db_xref="UniProtKB/Swiss-Prot:O34588" /translation="MSQLMGIITRLQSLQETAEAANEPMQRYFEVNGEKICSVKYFEK NQTFELTVFQKGEKPNTYPFDNIDMVSIEIFELLQ*" /label="ykuJ CDS" gene 1396445..1396684 /gene="ykuJ" /locus_tag="BSU_14100" /old_locus_tag="BSU14100" /label="ykuJ gene" S_feature 1396685..1396793 /Source="Nicolas_S_feature" /locus_tag="new_1484357_1484465" /HighExp="H2O2, LoTm, G135, Paraq, G180, LBGexp, G150, Oxctl, dia0, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF, SigEF, SigA" /TUshortPSig="1, 0.999, 0.997, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S515" CDS 1396794..1397312 /gene="ykuK" /locus_tag="BSU_14110" /old_locus_tag="BSU14110" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16165328, 24464998; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA-binding enzyme component" /protein_id="NP_389294.1" /db_xref="EnsemblGenomes-Gn:BSU14110" /db_xref="EnsemblGenomes-Tr:CAB13284" /db_xref="InterPro:IPR007405" /db_xref="SubtiList:BG13295" /db_xref="UniProtKB/Swiss-Prot:O34776" /translation="MADSFLFYNLSEAQMTFQDVMERLKAFVQKDPRSSYVLSIGTDS QVYRDYTKFITALHLHRTGKGAWGCLKNHTVDRPIHSLREKISLETAYSQETAAHILD GHLMDITDLLLPFTGEGADLTFEVHLDIGKKGLTKDLIQEMTGRITSMGIEAKIKPDS YTAFSYANRFTK*" /label="ykuK CDS" gene 1396794..1397312 /gene="ykuK" /locus_tag="BSU_14110" /old_locus_tag="BSU14110" /label="ykuK gene" promotor_-35 1397349..1397356 /Source="Nicolas_upshift_promotors" /id="U1166" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.946053946053946" /psig=1 /xcortree=454 /SigmaFactorBS="aagccaaggtaaatgtcgaattatgCGGTTGACgtttgttat ctgaTTACTTATTCTAGCGGTAGAgctgaaagtaagttgtcttgctttcagaggtatt c" /listShort="ykzF, S516, ykuL, S517, ccpC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1397370..1397389 /Source="Nicolas_upshift_promotors" /id="U1166" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.946053946053946" /psig=1 /xcortree=454 /SigmaFactorBS="aagccaaggtaaatgtcgaattatgCGGTTGACgtttgttat ctgaTTACTTATTCTAGCGGTAGAgctgaaagtaagttgtcttgctttcagaggtatt c" /listShort="ykzF, S516, ykuL, S517, ccpC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1397384 /Source="Nicolas_upshifts" /id="U1166" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.946053946053946" /psig=1 /xcortree=454 /SigmaFactorBS="aagccaaggtaaatgtcgaattatgCGGTTGACgtttgttat ctgaTTACTTATTCTAGCGGTAGAgctgaaagtaagttgtcttgctttcagaggtatt c" /listShort="ykzF, S516, ykuL, S517, ccpC" /GFF_Attribute="listLong" /label="upshifts" CDS 1397446..1397643 /gene="abbA" /locus_tag="BSU_14120" /old_locus_tag="BSU14120" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:18840696, 24534728" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18840696, 24534728; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of AbrB repressor" /protein_id="NP_389295.1" /db_xref="EnsemblGenomes-Gn:BSU14120" /db_xref="EnsemblGenomes-Tr:CAB13285" /db_xref="GOA:O31697" /db_xref="InterPro:IPR025446" /db_xref="PDB:2LZF" /db_xref="SubtiList:BG13334" /db_xref="UniProtKB/Swiss-Prot:O31697" /translation="MRMSLIGERFTEEEQKLLLNILINHEYAIELLSSEINDIETGTK NVDGTTYKKLVTLYDRFRFEN*" /label="abbA CDS" gene 1397446..1397643 /gene="abbA" /locus_tag="BSU_14120" /old_locus_tag="BSU14120" /label="abbA gene" downshifts 1397639 /Source="Nicolas_upshifts" /id="D790" /incds=0 /nref=114 /ntot=265 /MaxReadThrough="5.72556" /MaxDrop="4.65809" /score="2.45376472" /energy="-6.8" /TU="U1165,U1166" /idTUdmin="U1162" /TUdmin=12 /isTUend="TRUE" /label="downshifts" S_feature 1397684..1397780 /Source="Nicolas_S_feature" /locus_tag="new_1485356_1485452" /HighExp="M9-stat, T3.30H, T3.0H, T4.0H, M0t90, T1.0H, T5.0H, T2.30H, T1.30H, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.23094000000000001" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="SigGF, SigEF, SigA" /TUlongPSig="0.999, 0.997, 1" /label="S516" CDS 1397781..1398224 /gene="ykuL" /locus_tag="BSU_14130" /old_locus_tag="BSU14130" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11985717; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative RNA-binding protein" /protein_id="NP_389296.1" /db_xref="EnsemblGenomes-Gn:BSU14130" /db_xref="EnsemblGenomes-Tr:CAB13286" /db_xref="PDB:1YAV" /db_xref="SubtiList:BG13296" /db_xref="UniProtKB/Swiss-Prot:O31698" /translation="MISLQSDQLLEATVGQFMIEADKVAHVQVGNNLEHALLVLTKTG YTAIPVLDPSYRLHGLIGTNMIMNSIFGLERIEFEKLDQITVEEVMLTDIPRLHINDP IMKGFGMVINNGFVCVENDEQVFEGIFTRRVVLKELNKHIRSLNK*" /label="ykuL CDS" gene 1397781..1398224 /gene="ykuL" /locus_tag="BSU_14130" /old_locus_tag="BSU14130" /label="ykuL gene" S_feature 1398225..1398332 /Source="Nicolas_S_feature" /locus_tag="new_1485897_1486004" /HighExp="M0t90, M40t90, M9-stat, T1.0H, T3.30H, T3.0H, T4.0H, S2, T1.30H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="SigGF, SigEF, SigA" /TUlongPSig="0.999, 0.997, 1" /label="S517" promotor_-35 1398300..1398305 /Source="Nicolas_upshift_promotors" /id="U1167" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.473526473526474" /psig="0.998001998001998" /xcortree=3032 /SigmaFactorBS="catacataatttaaacgagaatagggCTTGAAtaagaaacta agatTTTATTAGAATGGGAGATAAgaaaaacttattgataacaaaaaggaggacgaca t" /listShort="ccpC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1398320..1398339 /Source="Nicolas_upshift_promotors" /id="U1167" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.473526473526474" /psig="0.998001998001998" /xcortree=3032 /SigmaFactorBS="catacataatttaaacgagaatagggCTTGAAtaagaaacta agatTTTATTAGAATGGGAGATAAgaaaaacttattgataacaaaaaggaggacgaca t" /listShort="ccpC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1398334 /Source="Nicolas_upshifts" /id="U1167" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.473526473526474" /psig="0.998001998001998" /xcortree=3032 /SigmaFactorBS="catacataatttaaacgagaatagggCTTGAAtaagaaacta agatTTTATTAGAATGGGAGATAAgaaaaacttattgataacaaaaaggaggacgaca t" /listShort="ccpC" /GFF_Attribute="listLong" /label="upshifts" CDS 1398373..1399254 /gene="ccpC" /locus_tag="BSU_14140" /old_locus_tag="BSU14140" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14636591, 16352834, 16395550, 23139400" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14636591, 16352834, 16395550, 23139400; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of citB and citZ" /protein_id="NP_389297.1" /db_xref="EnsemblGenomes-Gn:BSU14140" /db_xref="EnsemblGenomes-Tr:CAB13287" /db_xref="GOA:O34827" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13297" /db_xref="UniProtKB/Swiss-Prot:O34827" /translation="MQLQELHMLVVLAEELNMRKAAERLFVSQPALSQRLQTIEKAWG TKIFLRSQKGLTVTPAGEKIIQFANDVTLEQERIRENIDELEGEIHGTLKLAVASIIG QHWLPKVLKTYVEKYPNAKISLITGWSSEMLKSLYEDQVHIGIIRGNPEWKGRKDYLM TDHLYLVDTEISCIEDIAHTERPFIQFKSDSTYFQEIQHWWHQKFKTSPKQTILVDQI ETCKQMALHGIGYAILPSVTLQNEDKVNKMPLLDMKGHPIGRDTWLLGYEPAFELKQV QAFVQVIKDMLDQENPF*" /label="ccpC CDS" gene 1398373..1399254 /gene="ccpC" /locus_tag="BSU_14140" /old_locus_tag="BSU14140" /label="ccpC gene" downshifts 1399233 /Source="Nicolas_upshifts" /id="D791" /incds=0 /nref=168 /ntot=242 /MaxReadThrough="1.76921" /MaxDrop="5.2505" /score="37.6563581" /energy="-8.3" /TU="NA" /idTUdmin="U1165" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1399289..1399296 /Source="Nicolas_upshift_promotors" /id="U1168" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.614385614385614" /psig=1 /xcortree=2113 /SigmaFactorBS="gacagcgaggtgctgtcttttttttatttatctGTTGACAAt gaaaatcattatcATTTAAAGTGATACATATGAtattgaaaatcattatcaactaatg g" /listShort="ykuN, ykuO, ykuP, dapH, dapL, ykuS" /listLong="S518, S519, ykuU, ykuV" /label="promotor_-35" promotor_-10 1399311..1399330 /Source="Nicolas_upshift_promotors" /id="U1168" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.614385614385614" /psig=1 /xcortree=2113 /SigmaFactorBS="gacagcgaggtgctgtcttttttttatttatctGTTGACAAt gaaaatcattatcATTTAAAGTGATACATATGAtattgaaaatcattatcaactaatg g" /listShort="ykuN, ykuO, ykuP, dapH, dapL, ykuS" /listLong="S518, S519, ykuU, ykuV" /label="promotor_-10" upshifts 1399316 /Source="Nicolas_upshifts" /id="U1168" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.614385614385614" /psig=1 /xcortree=2113 /SigmaFactorBS="gacagcgaggtgctgtcttttttttatttatctGTTGACAAt gaaaatcattatcATTTAAAGTGATACATATGAtattgaaaatcattatcaactaatg g" /listShort="ykuN, ykuO, ykuP, dapH, dapL, ykuS" /listLong="S518, S519, ykuU, ykuV" /label="upshifts" CDS 1399366..1399842 /gene="fldN" /locus_tag="BSU_14150" /old_locus_tag="BSU14150" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12354229, 15449930, 17127770, 20186410, 21665975, 24214949" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15449930, 17127770, 20186410, 21665975, 24214949; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="short-chain flavodoxin (acts in lipid desaturation)" /protein_id="NP_389298.1" /db_xref="EnsemblGenomes-Gn:BSU14150" /db_xref="EnsemblGenomes-Tr:CAB13288" /db_xref="GOA:O34737" /db_xref="InterPro:IPR001094" /db_xref="InterPro:IPR008254" /db_xref="InterPro:IPR010087" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG13298" /db_xref="UniProtKB/Swiss-Prot:O34737" /translation="MAKALITYASMSGNTEDIAFIIKDTLQEYELDIDCVEINDMDAS CLTSYDYVLIGTYTWGDGDLPYEAEDFFEEVKQIQLNGLKTACFGSGDYSYPKFCEAV NLFNVMLQEAGAAVYQETLKIELAPETDEDVESCRAFARGFLAWADYMNKEKIHVS*" /label="fldN CDS" gene 1399366..1399842 /gene="fldN" /locus_tag="BSU_14150" /old_locus_tag="BSU14150" /label="fldN gene" CDS 1399832..1400725 /gene="ykuO" /locus_tag="BSU_14160" /old_locus_tag="BSU14160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12354229, 24214949" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389299.1" /db_xref="EnsemblGenomes-Gn:BSU14160" /db_xref="EnsemblGenomes-Tr:CAB13289" /db_xref="InterPro:IPR015943" /db_xref="SubtiList:BG13299" /db_xref="UniProtKB/Swiss-Prot:O34879" /translation="MFHKGATAVTASAFSGYFVAVQREGIFHYSLEQGWRKLFRLKSK IHCISYIGPYLFGVGEKGTVIRSADEGKTWTMSSFPTNATVWAITGRNNGFVCAHGKH CIYVSDDFGVSWRVAKPFAEFHNPPVIRSLCLHGGNLFIGTQIHEYFGGIWAYDIKRD TVQVVKKEKNRMTASMLVFNENWLVAAMGSVKGKHGAVTVRNLLNGEEFTIQSSMIRN EESFLDLSEDDGIIYVTTTQDENGFSRIYQVDLEARSLKWFDTIKGHGWRVANQKENF FCAGLYECKFVQPYEVSAMIH*" /label="ykuO CDS" gene 1399832..1400725 /gene="ykuO" /locus_tag="BSU_14160" /old_locus_tag="BSU14160" /label="ykuO gene" CDS 1400741..1401196 /gene="fldP" /locus_tag="BSU_14170" /old_locus_tag="BSU14170" /experiment="publication(s) with functional evidences, PMID:12354229, 15449930, 17127770, 20186410, 21665975, 24214949" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15449930, 17127770, 20186410, 21665975, 24214949; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="short-chain flavodoxin" /protein_id="NP_389300.2" /db_xref="EnsemblGenomes-Gn:BSU14170" /db_xref="EnsemblGenomes-Tr:CAB13290" /db_xref="GOA:O34589" /db_xref="InterPro:IPR001094" /db_xref="InterPro:IPR001226" /db_xref="InterPro:IPR008254" /db_xref="InterPro:IPR010087" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG13300" /db_xref="UniProtKB/Swiss-Prot:O34589" /translation="MAKILLVYATMSGNTEAMADLIEKGLQEALAEVDRFEAMDIDDA QLFTDYDHVIMGTYTWGDGDLPDEFLDLVEDMEEIDFSGKTCAVFGSGDTAYEFFCGA VDTLEAKIKERGGDIVLPSVKIENNPEGEEEEELINFGRQFAKKSGCAV*" /label="fldP CDS" gene 1400741..1401196 /gene="fldP" /locus_tag="BSU_14170" /old_locus_tag="BSU14170" /label="fldP gene" promotor_-10 complement(1401012..1401031) /Source="Nicolas_upshift_promotors" /id="U1169" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.88011988011988" /psig="0.88011988011988" /xcortree=766 /SigmaFactorBS="tccaccgcgttcttttatttttgcctctagcgTATCAACCGc tccgcagaaaaaTTCATATGCTGTATCACCGGaaccgaatacagcgcatgttttgccg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1401025) /Source="Nicolas_upshifts" /id="U1169" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.88011988011988" /psig="0.88011988011988" /xcortree=766 /SigmaFactorBS="tccaccgcgttcttttatttttgcctctagcgTATCAACCGc tccgcagaaaaaTTCATATGCTGTATCACCGGaaccgaatacagcgcatgttttgccg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1401045..1401053) /Source="Nicolas_upshift_promotors" /id="U1169" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.88011988011988" /psig="0.88011988011988" /xcortree=766 /SigmaFactorBS="tccaccgcgttcttttatttttgcctctagcgTATCAACCGc tccgcagaaaaaTTCATATGCTGTATCACCGGaaccgaatacagcgcatgttttgccg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1401190 /Source="Nicolas_upshifts" /id="D792" /incds=0 /nref=2 /ntot=54 /MaxReadThrough="6.48855" /MaxDrop="3.75748" /score="20.7202933" /energy="-9" /TU="U1168" /idTUdmin="U1165" /TUdmin=1957 /isTUend="FALSE" /label="downshifts" promotor_-35 1401235..1401242 /Source="Nicolas_upshift_promotors" /id="U1170" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.49050949050949" /psig=1 /xcortree=2341 /SigmaFactorBS="tcactcactgggaactgctaaaacggctgttcctttttTTCT TGTCtttgtatctttccTTTGATACAGTAATGAGGTAgaaaatcaggaggaggactat a" /listShort="dapH, dapL, ykuS" /listLong="S518, S519, ykuU, ykuV" /label="promotor_-35" promotor_-10 1401256..1401275 /Source="Nicolas_upshift_promotors" /id="U1170" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.49050949050949" /psig=1 /xcortree=2341 /SigmaFactorBS="tcactcactgggaactgctaaaacggctgttcctttttTTCT TGTCtttgtatctttccTTTGATACAGTAATGAGGTAgaaaatcaggaggaggactat a" /listShort="dapH, dapL, ykuS" /listLong="S518, S519, ykuU, ykuV" /label="promotor_-10" upshifts 1401257 /Source="Nicolas_upshifts" /id="U1170" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.49050949050949" /psig=1 /xcortree=2341 /SigmaFactorBS="tcactcactgggaactgctaaaacggctgttcctttttTTCT TGTCtttgtatctttccTTTGATACAGTAATGAGGTAgaaaatcaggaggaggactat a" /listShort="dapH, dapL, ykuS" /listLong="S518, S519, ykuU, ykuV" /label="upshifts" CDS 1401301..1402011 /gene="dapH" /locus_tag="BSU_14180" /old_locus_tag="BSU14180" /EC_number="2.3.1.89" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:5411754, 10368155, 11910040, 12682299, 14627808" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 5411754, 10368155, 11910040, 12682299, 14627808; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tetrahydrodipicolinate N-acetyltransferase" /protein_id="NP_389301.2" /db_xref="EnsemblGenomes-Gn:BSU14180" /db_xref="EnsemblGenomes-Tr:CAB13291" /db_xref="GOA:O34981" /db_xref="InterPro:IPR001451" /db_xref="InterPro:IPR011004" /db_xref="InterPro:IPR013710" /db_xref="InterPro:IPR016036" /db_xref="InterPro:IPR018357" /db_xref="InterPro:IPR019873" /db_xref="SubtiList:BG13301" /db_xref="UniProtKB/Swiss-Prot:O34981" /translation="MKMMDANEIISFIQNSTKSTPVKVYVKGELEGINFGESAKAFIN GNTGVVFGEWSEIQTAIEENQSKIEDYVVENDRRNSAIPMLDLKNIKARIEPGAIIRD QVEIGDNAVIMMGASINIGSVIGEGTMIDMNVVLGGRATVGKNCHIGAGSVLAGVIEP PSAKPVVIEDDVVIGANAVVLEGVTVGKGAVVAAGAIVVNDVEPYTVVAGTPAKKIKD IDEKTKGKTEIKQELRQL*" /label="dapH CDS" gene 1401301..1402011 /gene="dapH" /locus_tag="BSU_14180" /old_locus_tag="BSU14180" /label="dapH gene" downshifts complement(1401310) /Source="Nicolas_upshifts" /id="D793" /incds=0 /nref=60 /ntot=165 /MaxReadThrough="1.03272" /MaxDrop="4.75802" /score="28.9046709" /energy="-15" /TU="NA" /idTUdmin="U1171" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1401420..1401424) /Source="Nicolas_upshift_promotors" /id="U1171" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.977022977022977" /psig="0.005994005994006" /xcortree=40 /SigmaFactorBS="tgctgtttggatttcgctccattcaccgaaaacgacacCagt gtttccattgataaAAGCTttcgcagattcaccgaaattgattccttccagctcacct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1401420) /Source="Nicolas_upshifts" /id="U1171" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.977022977022977" /psig="0.005994005994006" /xcortree=40 /SigmaFactorBS="tgctgtttggatttcgctccattcaccgaaaacgacacCagt gtttccattgataaAAGCTttcgcagattcaccgaaattgattccttccagctcacct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 1402081..1403205 /gene="dapI" /locus_tag="BSU_14190" /old_locus_tag="BSU14190" /EC_number="3.5.1.47" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14627808, 17093042, 24261876" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14627808, 17093042, 24261876; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetyl-diaminopimelate deacetylase" /protein_id="NP_389302.1" /db_xref="EnsemblGenomes-Gn:BSU14190" /db_xref="EnsemblGenomes-Tr:CAB13292" /db_xref="GOA:O34916" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR017439" /db_xref="InterPro:IPR023905" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG13302" /db_xref="UniProtKB/Swiss-Prot:O34916" /translation="MKIEELIAIRRDLHRIPELGFQEFKTQQYLLNVLEQYPQDRIEI EKWRTGLFVKVNGTAPEKMLAYRADIDALSIEEQTGLPFASEHHGNMHACGHDLHMTI ALGIIDHFVHHPVKHDLLFLFQPAEEGPGGAEPMLESDVLKKWQPDFITALHIAPELP VGTIATKSGLLFANTSELVIDLEGKGGHAAYPHLAEDMVVAASTLVTQLQTIISRNTD PLDSAVITVGTITGGSAQNIIAETAHLEGTIRTLSEESMKQVKERIEDVVKGIEIGFR CKGKVTYPSVYHQVYNTSGLTEEFMSFVAEHQLATVIEAKEAMTGEDFGYMLKKYPGF MFWLGADSEHGLHHAKLNPDENAIETAVHVMTGYFSVYAN*" /label="dapI CDS" gene 1402081..1403205 /gene="dapI" /locus_tag="BSU_14190" /old_locus_tag="BSU14190" /label="dapI gene" promotor_-35 1403217..1403223 /Source="Nicolas_upshift_promotors" /id="U1172" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=883 /SigmaFactorBS="ggttatttttctgtttatgccaattaagtacaaatgaaAGAA TAAaattccataaaatGAGCACTCTAGTaaacggaggtgttcaaaaatggctaaaaaa a" /listShort="ykuS, S518, S519, ykuU, ykuV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1403237..1403248 /Source="Nicolas_upshift_promotors" /id="U1172" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=883 /SigmaFactorBS="ggttatttttctgtttatgccaattaagtacaaatgaaAGAA TAAaattccataaaatGAGCACTCTAGTaaacggaggtgttcaaaaatggctaaaaaa a" /listShort="ykuS, S518, S519, ykuU, ykuV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1403239 /Source="Nicolas_upshifts" /id="U1172" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=883 /SigmaFactorBS="ggttatttttctgtttatgccaattaagtacaaatgaaAGAA TAAaattccataaaatGAGCACTCTAGTaaacggaggtgttcaaaaatggctaaaaaa a" /listShort="ykuS, S518, S519, ykuU, ykuV" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1403243..1403257) /Source="Nicolas_upshift_promotors" /id="U1173" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=701 /SigmaFactorBS="ttttcttttaaagcagcttctacatctgataacgattgttca attccaatttttttaGCCATttttgaacaCCTCCGTTTACTAGAgtgctcattttatg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1403267..1403271) /Source="Nicolas_upshift_promotors" /id="U1173" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=701 /SigmaFactorBS="ttttcttttaaagcagcttctacatctgataacgattgttca attccaatttttttaGCCATttttgaacaCCTCCGTTTACTAGAgtgctcattttatg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1403267..1403512 /gene="ykuS" /locus_tag="BSU_14200" /old_locus_tag="BSU14200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389303.1" /db_xref="EnsemblGenomes-Gn:BSU14200" /db_xref="EnsemblGenomes-Tr:CAB13293" /db_xref="InterPro:IPR005370" /db_xref="SubtiList:BG13303" /db_xref="UniProtKB/Swiss-Prot:O34783" /translation="MAKKIGIEQSLSDVEAALKEKGYDVVMMKSPADAQGCDCCVVTG LDNNVQGIADTVTQAPVITASGMTAEEICSEVESRIQ*" /label="ykuS CDS" gene 1403267..1403512 /gene="ykuS" /locus_tag="BSU_14200" /old_locus_tag="BSU14200" /label="ykuS gene" upshifts complement(1403268) /Source="Nicolas_upshifts" /id="U1173" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=701 /SigmaFactorBS="ttttcttttaaagcagcttctacatctgataacgattgttca attccaatttttttaGCCATttttgaacaCCTCCGTTTACTAGAgtgctcattttatg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1403500 /Source="Nicolas_upshifts" /id="D794" /incds=0 /nref=238 /ntot=269 /MaxReadThrough="3.49553" /MaxDrop="5.88829" /score="3.56597112" /energy="-9.9" /TU="U1172" /idTUdmin="U1168" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 1403545..1404495 /Source="Nicolas_S_feature" /locus_tag="new_1491217_1492167" /HighExp="S4, S5, S6, S3, S7, S8, LoTm, BT, B36, G135" /AntisenseName="ykuT" /AntisenseCor="-0.479447808227356" /AntisenseRegPval="-16.100000000000001" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S518" CDS complement(1403549..1404352) /gene="mscT" /locus_tag="BSU_14210" /old_locus_tag="BSU14210" /function="16.6: Maintain" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12626684, 17665170, 18310427, 19252899, 21150093" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12626684, 17665170, 18310427, 19252899, 21150093; Product type t : transporter" /codon_start=1 /transl_table=11 /product="small-conductance mechanosensitive channel" /protein_id="NP_389304.2" /db_xref="EnsemblGenomes-Gn:BSU14210" /db_xref="EnsemblGenomes-Tr:CAB13294" /db_xref="GOA:O34897" /db_xref="InterPro:IPR006685" /db_xref="InterPro:IPR010920" /db_xref="InterPro:IPR011014" /db_xref="InterPro:IPR011066" /db_xref="SubtiList:BG13304" /db_xref="UniProtKB/Swiss-Prot:O34897" /translation="MDFIKQYDWAGLITNAGVLLIKLAIMILLYFIVRSLGMKIIKHL FAKFEEQNSLSIGRAHTLRSLTLNIFAYTLIFIFFVMVLDLFHYDPSALLAGAGIVGL AVGFGAQGLVSDIVTGFFILLEKQLDVGDYITVSTFDGIVEQVGLRTTQIRSFDGTLH YIPNRNITNVSNHSRGTMQALVDIKVPAERNIDEMIHILQQVCDETAAALPQIKEGPN VIGIQELGTSEIVIRVIAKTENMEQWRVERVLRKEIKNAFDRAFPKETE*" /label="mscT CDS" gene complement(1403549..1404352) /gene="mscT" /locus_tag="BSU_14210" /old_locus_tag="BSU14210" /label="mscT gene" downshifts complement(1403561) /Source="Nicolas_upshifts" /id="D795" /incds=0 /nref=16 /ntot=131 /MaxReadThrough="1.65551" /MaxDrop="4.4361" /score="29.0050313" /energy="-9.9" /TU="NA" /idTUdmin="U1174" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1404403..1404422) /Source="Nicolas_upshift_promotors" /id="U1174" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.892107892107892" /psig="0.975024975024975" /xcortree=2730 /SigmaFactorBS="caatttttaacaaatcatgtatgtctttgGCTTCGACatttt tgaataaaACGTTTAACATGGTCATGTAcagggtaactagtctcaatgtgcagcaatc a" /listShort="ykuT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1404412) /Source="Nicolas_upshifts" /id="U1174" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.892107892107892" /psig="0.975024975024975" /xcortree=2730 /SigmaFactorBS="caatttttaacaaatcatgtatgtctttgGCTTCGACatttt tgaataaaACGTTTAACATGGTCATGTAcagggtaactagtctcaatgtgcagcaatc a" /listShort="ykuT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1404436..1404443) /Source="Nicolas_upshift_promotors" /id="U1174" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.892107892107892" /psig="0.975024975024975" /xcortree=2730 /SigmaFactorBS="caatttttaacaaatcatgtatgtctttgGCTTCGACatttt tgaataaaACGTTTAACATGGTCATGTAcagggtaactagtctcaatgtgcagcaatc a" /listShort="ykuT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1404468..1404475 /Source="Nicolas_upshift_promotors" /id="U1175" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.849150849150849" /psig="0.999000999001" /xcortree=3170 /SigmaFactorBS="tcgaagccaaagacatacatgatttgttaaaAATTGACTcag gaaatctgcttTTATATAATGGCATTGCAATataactaaaaatggttaatcacccttt a" /listShort="S519, ykuU, ykuV" /listLong="rok" /label="promotor_-35" promotor_-10 1404490..1404509 /Source="Nicolas_upshift_promotors" /id="U1175" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.849150849150849" /psig="0.999000999001" /xcortree=3170 /SigmaFactorBS="tcgaagccaaagacatacatgatttgttaaaAATTGACTcag gaaatctgcttTTATATAATGGCATTGCAATataactaaaaatggttaatcacccttt a" /listShort="S519, ykuU, ykuV" /listLong="rok" /label="promotor_-10" S_feature 1404497..1404588 /Source="Nicolas_S_feature" /locus_tag="new_1492169_1492260" /HighExp="LPhT, Salt, Etha, M9-stat, M0t90, T4.0H, T5.0H, S4, Heat, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF" /TUshortPSig="0.999, 1" /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S519" upshifts 1404497 /Source="Nicolas_upshifts" /id="U1175" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.849150849150849" /psig="0.999000999001" /xcortree=3170 /SigmaFactorBS="tcgaagccaaagacatacatgatttgttaaaAATTGACTcag gaaatctgcttTTATATAATGGCATTGCAATataactaaaaatggttaatcacccttt a" /listShort="S519, ykuU, ykuV" /listLong="rok" /label="upshifts" CDS 1404589..1405131 /gene="ahpA" /locus_tag="BSU_14220" /old_locus_tag="BSU14220" /EC_number="1.11.1.-" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:22938038, 27683249" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22938038, 27683249; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="biofilm-specific peroxidase; 2-cys peroxiredoxin" /protein_id="NP_389305.1" /db_xref="EnsemblGenomes-Gn:BSU14220" /db_xref="EnsemblGenomes-Tr:CAB13295" /db_xref="GOA:O34564" /db_xref="InterPro:IPR000866" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR019479" /db_xref="InterPro:IPR024706" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG13305" /db_xref="UniProtKB/Swiss-Prot:O34564" /translation="MAERMVGKQAPRFEMEAVLASKEFGKVSLEENMKNDKWTVLFFY PMDFTFVCPTEITAMSDRYDEFEDLDAEVIGVSTDTIHTHLAWINTDRKENGLGQLKY PLAADTNHEVSREYGVLIEEEGVALRGLFIINPEGELQYQTVFHNNIGRDVDETLRVL QALQTGGLCPANWKPGQKTL*" /label="ahpA CDS" gene 1404589..1405131 /gene="ahpA" /locus_tag="BSU_14220" /old_locus_tag="BSU14220" /label="ahpA gene" CDS 1405203..1405649 /gene="ykuV" /locus_tag="BSU_14230" /old_locus_tag="BSU14230" /EC_number="1.8.-.-" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:15937154, 16132829, 16418167" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15937154, 16132829, 16418167; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thiol-disulfide oxidoreductase" /protein_id="NP_389306.2" /db_xref="EnsemblGenomes-Gn:BSU14230" /db_xref="EnsemblGenomes-Tr:CAB13296" /db_xref="GOA:O31699" /db_xref="InterPro:IPR000866" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR036249" /db_xref="PDB:2B5X" /db_xref="PDB:2B5Y" /db_xref="SubtiList:BG13306" /db_xref="UniProtKB/Swiss-Prot:O31699" /translation="MKLRQPMPELTGEKAWLNGEVTREQLIGEKPTLIHFWSISCHLC KEAMPQVNEFRDKYQDQLNVVAVHMPRSEDDLDPGKIKETAAEHDITQPIFVDSDHAL TDAFENEYVPAYYVFDKTGQLRHFQAGGSGMKMLEKRVNRVLAETE*" /label="ykuV CDS" gene 1405203..1405649 /gene="ykuV" /locus_tag="BSU_14230" /old_locus_tag="BSU14230" /label="ykuV gene" downshifts 1405657 /Source="Nicolas_upshifts" /id="D796" /incds=0 /nref=58 /ntot=211 /MaxReadThrough="3.11112" /MaxDrop="4.73023" /score="10.8864177" /energy="-5.4" /TU="U1175" /idTUdmin="U1172" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1406042..1406049 /Source="Nicolas_upshift_promotors" /id="U1176" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.884115884115884" /psig=1 /xcortree=2393 /SigmaFactorBS="ttttcatagagtaaatataatagtaaaatgctaaaataatAG TTGATAaaattacttttgtaATCTAATATCTTAATTAAAGatgttaattttgataggg g" /listShort="rok" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1406062 /Source="Nicolas_upshifts" /id="U1176" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.884115884115884" /psig=1 /xcortree=2393 /SigmaFactorBS="ttttcatagagtaaatataatagtaaaatgctaaaataatAG TTGATAaaattacttttgtaATCTAATATCTTAATTAAAGatgttaattttgataggg g" /listShort="rok" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1406064..1406083 /Source="Nicolas_upshift_promotors" /id="U1176" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.884115884115884" /psig=1 /xcortree=2393 /SigmaFactorBS="ttttcatagagtaaatataatagtaaaatgctaaaataatAG TTGATAaaattacttttgtaATCTAATATCTTAATTAAAGatgttaattttgataggg g" /listShort="rok" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1406115..1406690 /gene="rok" /locus_tag="BSU_14240" /old_locus_tag="BSU14240" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15743949, 15819619, 27902860" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15743949, 15819619, 27902860; Product type r: regulator" /codon_start=1 /transl_table=11 /product="repressor of comK" /protein_id="NP_389307.1" /db_xref="EnsemblGenomes-Gn:BSU14240" /db_xref="EnsemblGenomes-Tr:CAB13297" /db_xref="GOA:O34857" /db_xref="SubtiList:BG13307" /db_xref="UniProtKB/Swiss-Prot:O34857" /translation="MFNEREALRLRLEQLNEAEVKVIREYQIERDKIYAKLRELDRNG SPSEIKKDFRSEKKPDSLPVLAELAAQEIRSYQPQSQQQSVQPQLQSISSLPAGIPDG TTRRRRGTARPGSKAAKLREAAIKTLKRHNAAIKSSELQKEIEKESGLEIPNMTTFMQ SLIKMYPEVKKPYRGQYILEGEIESAESANE*" /label="rok CDS" gene 1406115..1406690 /gene="rok" /locus_tag="BSU_14240" /old_locus_tag="BSU14240" /label="rok gene" downshifts 1406668 /Source="Nicolas_upshifts" /id="D797" /incds=0 /nref=246 /ntot=258 /MaxReadThrough="1.77207" /MaxDrop="6.35121" /score="17.7584572" /energy="-9" /TU="NA" /idTUdmin="U1176" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1406731..1407696) /gene="sppO" /locus_tag="BSU_14250" /old_locus_tag="BSU14250" /experiment="publication(s) with functional evidences, PMID:8990290, 15383836, 15743949" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8990290, 15383836, 15743949; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore protein cse15" /protein_id="NP_389308.1" /db_xref="EnsemblGenomes-Gn:BSU14250" /db_xref="EnsemblGenomes-Tr:CAB13298" /db_xref="GOA:O31700" /db_xref="SubtiList:BG12251" /db_xref="UniProtKB/Swiss-Prot:O31700" /translation="MKRSGPFFHDVSQENLYLKSELSRCHKLISELEASYFHQKNNKL LKENTDMKEKLQQLSAELTHMSTKEKHASHTSQTLHQIRAELLDKIVVLQELLSAETY KRRAEIEEKHKLHIAKVKIEEENKNLHKRISELQASIEQEQNALLQAKQQAELIKAEN GRLKEQMVEKEYQLKHIKIEVDHMKDRIIETKERLLDIEKTKEKLFHETIISYKRQLD ESDAWIASHFADIDGGTKQKEKTEEEAPAAYAQPNHVETILEDVTKQIHVLQKQLAHA QSSDQAKSHTIEELKNRAAEEKPYQKWVYKLNLEKENKPSQKKPQ*" /label="sppO CDS" gene complement(1406731..1407696) /gene="sppO" /locus_tag="BSU_14250" /old_locus_tag="BSU14250" /label="sppO gene" downshifts complement(1406744) /Source="Nicolas_upshifts" /id="D798" /incds=0 /nref=47 /ntot=67 /MaxReadThrough="2.24884" /MaxDrop="5.5936" /score="3.60334458" /energy="-7.2" /TU="NA" /idTUdmin="U1178" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1407040..1407041 /Source="Nicolas_upshift_promotors" /id="U1177" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.547452547452547" /psig="0.988011988011988" /xcortree=1801 /SigmaFactorBS="atatcggcaaaatgagaagcaatccaggcatcgctTTcatca agttgccgtttaTACGATATAATAGTTTCGTGaaataatttttctttcgttttttcta t" /listShort="S520, mobA, moeB, moeA, mobB, moaE, moaD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1407059..1407078 /Source="Nicolas_upshift_promotors" /id="U1177" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.547452547452547" /psig="0.988011988011988" /xcortree=1801 /SigmaFactorBS="atatcggcaaaatgagaagcaatccaggcatcgctTTcatca agttgccgtttaTACGATATAATAGTTTCGTGaaataatttttctttcgttttttcta t" /listShort="S520, mobA, moeB, moeA, mobB, moaE, moaD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1407065..1407789 /Source="Nicolas_S_feature" /locus_tag="new_1494737_1495461" /HighExp="dia15, Diami, dia5, H2O2, G135, G150, G180, LBGexp, Paraq, Lbexp" /AntisenseName="yknT" /AntisenseCor="-0.36512493899072102" /AntisenseRegPval="-9.1999999999999993" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S520" upshifts 1407065 /Source="Nicolas_upshifts" /id="U1177" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.547452547452547" /psig="0.988011988011988" /xcortree=1801 /SigmaFactorBS="atatcggcaaaatgagaagcaatccaggcatcgctTTcatca agttgccgtttaTACGATATAATAGTTTCGTGaaataatttttctttcgttttttcta t" /listShort="S520, mobA, moeB, moeA, mobB, moaE, moaD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1407717..1407735) /Source="Nicolas_upshift_promotors" /id="U1178" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1151 /SigmaFactorBS="aaaagcaaaggctcaacgctactgcttgtctgtttattaaag aGGAATAgctgttcagtatttGCATATTGTAGTGTTAACAtcatgagggagatggttc g" /listShort="yknT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1407738) /Source="Nicolas_upshifts" /id="U1178" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1151 /SigmaFactorBS="aaaagcaaaggctcaacgctactgcttgtctgtttattaaag aGGAATAgctgttcagtatttGCATATTGTAGTGTTAACAtcatgagggagatggttc g" /listShort="yknT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1407750..1407755) /Source="Nicolas_upshift_promotors" /id="U1178" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1151 /SigmaFactorBS="aaaagcaaaggctcaacgctactgcttgtctgtttattaaag aGGAATAgctgttcagtatttGCATATTGTAGTGTTAACAtcatgagggagatggttc g" /listShort="yknT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1407776..1407782 /Source="Nicolas_upshift_promotors" /id="U1179" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.442557442557443" /psig="0.99000999000999" /xcortree=2673 /SigmaFactorBS="atgcaaatactgaacagctattcctctttaataaacagacaa gcAGTAGCGttgagcctttgctTTTGCTATGCTTTTAACGAAactagaggtgagatga t" /listShort="mobA, moeB, moeA, mobB, moaE, moaD" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1407792 /Source="Nicolas_upshifts" /id="U1179" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.442557442557443" /psig="0.99000999000999" /xcortree=2673 /SigmaFactorBS="atgcaaatactgaacagctattcctctttaataaacagacaa gcAGTAGCGttgagcctttgctTTTGCTATGCTTTTAACGAAactagaggtgagatga t" /listShort="mobA, moeB, moeA, mobB, moaE, moaD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1407796..1407815 /Source="Nicolas_upshift_promotors" /id="U1179" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.442557442557443" /psig="0.99000999000999" /xcortree=2673 /SigmaFactorBS="atgcaaatactgaacagctattcctctttaataaacagacaa gcAGTAGCGttgagcctttgctTTTGCTATGCTTTTAACGAAactagaggtgagatga t" /listShort="mobA, moeB, moeA, mobB, moaE, moaD" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1407833..1408432 /gene="mobA" /locus_tag="BSU_14260" /old_locus_tag="BSU14260" /EC_number="2.7.7.77" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10978347; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="molybdopterin-guanine dinucleotide biosynthesis protein A" /protein_id="NP_389309.1" /db_xref="EnsemblGenomes-Gn:BSU14260" /db_xref="EnsemblGenomes-Tr:CAB13299" /db_xref="GOA:O31701" /db_xref="InterPro:IPR013482" /db_xref="InterPro:IPR025877" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG12621" /db_xref="UniProtKB/Swiss-Prot:O31701" /translation="MKHVNVLLAGGASRRFGEPKAFVKWKGRMLYECAKEALGEQTVI ISRPEFIDRFQENGENEVYQDAEPFQGMGPLAGIYTAFKKTDGDLYTVLSCDTPLIQR RTMLELKRLMIAGADAVVPISDGQVQPLIAIYHKRIMPVLYDQLSEKRLRISDLLGRI SVCYVQAENIGANPAEFININTRDDFSCLEEKSNSLKRD*" /label="mobA CDS" gene 1407833..1408432 /gene="mobA" /locus_tag="BSU_14260" /old_locus_tag="BSU14260" /label="mobA gene" CDS 1408483..1409502 /gene="moeB" /locus_tag="BSU_14270" /old_locus_tag="BSU14270" /EC_number="2.7.7.80" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 17223713; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="molybdopterin biosynthesis adenylyltransferase" /protein_id="NP_389310.1" /db_xref="EnsemblGenomes-Gn:BSU14270" /db_xref="EnsemblGenomes-Tr:CAB13300" /db_xref="GOA:O31702" /db_xref="InterPro:IPR000594" /db_xref="InterPro:IPR035985" /db_xref="SubtiList:BG12624" /db_xref="UniProtKB/Swiss-Prot:O31702" /translation="MEERYSRQIRFKQIGEEGQKRLADSHVLIVGAGALGTAGAEGLS RAGVGTITIIDRDYVEWSNLQRQQLYTESDAKLRMPKAMAAKEHLSAINSEIHIEAYV TEGTAETLEPLIEKADVVIDATDNFETRMLINDLAQKTKTPWVYGACVSSQGMFMTVI PGETPCLSCLFEQIPVGGATCDTAGIIPPAVHIVSAYQQAEALKLLTGQKEAIQRGFV TFDVWNNSHMKINVNHVRREECPSCGANAVYPYLQDWNTPKAAVLCGRDTVQVRSESL KRIPKQELIKRLKTIGKVEANAFLLHIFYEDFRIVIFNDGRALVHGTNDVKEANSVLA RVIGL*" /label="moeB CDS" gene 1408483..1409502 /gene="moeB" /locus_tag="BSU_14270" /old_locus_tag="BSU14270" /label="moeB gene" CDS 1409520..1410812 /gene="moeA" /locus_tag="BSU_14280" /old_locus_tag="BSU14280" /EC_number="2.10.1.1" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 11428898, 12006571, 18959753, 21206014; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="molybdate to molybdopterin ligation enzyme" /protein_id="NP_389311.1" /db_xref="EnsemblGenomes-Gn:BSU14280" /db_xref="EnsemblGenomes-Tr:CAB13301" /db_xref="GOA:O31703" /db_xref="InterPro:IPR001453" /db_xref="InterPro:IPR005110" /db_xref="InterPro:IPR005111" /db_xref="InterPro:IPR036135" /db_xref="InterPro:IPR036425" /db_xref="InterPro:IPR036688" /db_xref="SubtiList:BG12623" /db_xref="UniProtKB/Swiss-Prot:O31703" /translation="MLEKRTPIPVDEAVRRVCHFQKQGETEWVALEDSLHRFLAEDIT ADHHVPAFDRSPYDGFAVRACDTAEASRENPVRFEVIDHIGAGAVSEKELGPFQAVRI MTGAQIPEGADAVVMIELTQAFEENGKSFMSLKRRFQTGDNISKTGEDAQKGSVLLTK GTRVTPGVTALLATFGYASVPVVRKPVVGIIATGTELLNVSDPLEPGKIRNSNASMVY AQAIEAGATPLYLGKISDELDKSFAAVKEAMKKVDFLITTGGVSVGDFDFLPAIYEKL GADVLFNKVAMRPGSVTTVAHANDMLLFGLSGNPSACYVGFELFVKPIIQTWLLNETP HSICAEAVLTKDFPKPNPFTRFVRALVHHQEGKLLATPVGLDKSSSVTSLADANAFII LPGGTRGYESGRTVQVLLIREENGSEWPWSVLSRSSKL*" /label="moeA CDS" gene 1409520..1410812 /gene="moeA" /locus_tag="BSU_14280" /old_locus_tag="BSU14280" /label="moeA gene" CDS 1410773..1411294 /gene="mobB" /locus_tag="BSU_14290" /old_locus_tag="BSU14290" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 9219527, 12682065, 12719427; Product type c: carrier" /codon_start=1 /transl_table=11 /product="molybdopterin-guanine dinucleotide biosynthesis protein B" /protein_id="NP_389312.1" /db_xref="EnsemblGenomes-Gn:BSU14290" /db_xref="EnsemblGenomes-Tr:CAB13302" /db_xref="GOA:O31704" /db_xref="InterPro:IPR004435" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12622" /db_xref="UniProtKB/Swiss-Prot:O31704" /translation="MALVRPFPIVQVVGFQNSGKTTFIERILEKASEQGVHLGCLKHH GHGGEPQTLTEGKDTDRYKAAGADVTAVEGAGVLQLTARRNWDLARLIELYQFLETDC LLIEGFKKAPYPKVVILSEKEDLEALQAVNIIAIIYRKKEHMTEHQGLPVFHADDPVA VDFVLSQLKGESA*" /label="mobB CDS" gene 1410773..1411294 /gene="mobB" /locus_tag="BSU_14290" /old_locus_tag="BSU14290" /label="mobB gene" CDS 1411294..1411767 /gene="moaE" /locus_tag="BSU_14300" /old_locus_tag="BSU14300" /EC_number="2.8.1.12" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 11135669, 18092812; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="molybdopterin synthase (large subunit)" /protein_id="NP_389313.1" /db_xref="EnsemblGenomes-Gn:BSU14300" /db_xref="EnsemblGenomes-Tr:CAB13303" /db_xref="GOA:O31705" /db_xref="InterPro:IPR003448" /db_xref="InterPro:IPR036563" /db_xref="SubtiList:BG12620" /db_xref="UniProtKB/Swiss-Prot:O31705" /translation="MERFEITKTPINTENIIKKVEKREAGAITTFIGTVREWTNGKRT VRLEYEAYEPMAVQMLAQIGAEIEEKWEGASAAITHRIGVLDIGEAAVVIAVSSPHRK AAYEANEYAIERIKQIVPIWKKEIWEDGEQWIGDQLETTAYPNGKPDLSEGEQHD*" /label="moaE CDS" gene 1411294..1411767 /gene="moaE" /locus_tag="BSU_14300" /old_locus_tag="BSU14300" /label="moaE gene" CDS 1411760..1411993 /gene="moaD" /locus_tag="BSU_14310" /old_locus_tag="BSU14310" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 11135669, 17223713, 19946146; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="molybdopterin synthase (small subunit)" /protein_id="NP_389314.1" /db_xref="EnsemblGenomes-Gn:BSU14310" /db_xref="EnsemblGenomes-Tr:CAB13304" /db_xref="GOA:O31706" /db_xref="InterPro:IPR003749" /db_xref="InterPro:IPR010034" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR016155" /db_xref="SubtiList:BG12619" /db_xref="UniProtKB/Swiss-Prot:O31706" /translation="MIKILLFAGLAEQAGTQAIEIDMEQATTDEIKASLKEQYGLESI DTAMIAVNESYVKENTSVSSGDTVAIIPPVSGG*" /label="moaD CDS" gene 1411760..1411993 /gene="moaD" /locus_tag="BSU_14310" /old_locus_tag="BSU14310" /label="moaD gene" downshifts 1411972 /Source="Nicolas_upshifts" /id="D799" /incds=0 /nref=87 /ntot=240 /MaxReadThrough="1.14308" /MaxDrop="5.73073" /score="32.0123217" /energy="-16.9" /TU="NA" /idTUdmin="U1177" /TUdmin=2 /isTUend="TRUE" /label="downshifts" promotor_-35 1412038..1412043 /Source="Nicolas_upshift_promotors" /id="U1180" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=954 /SigmaFactorBS="ttcagccgtccggtttttctgtatttcattGGCATAtcccca agtatcctcaGCATACAATGATTTTCTGTaagcgtttattctacatatgttactccct a" /listShort="S521, yknU, yknV" /listLong="yknW, yknX, yknY, yknZ" /label="promotor_-35" promotor_-10 1412060..1412078 /Source="Nicolas_upshift_promotors" /id="U1180" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=954 /SigmaFactorBS="ttcagccgtccggtttttctgtatttcattGGCATAtcccca agtatcctcaGCATACAATGATTTTCTGTaagcgtttattctacatatgttactccct a" /listShort="S521, yknU, yknV" /listLong="yknW, yknX, yknY, yknZ" /label="promotor_-10" upshifts 1412068 /Source="Nicolas_upshifts" /id="U1180" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=954 /SigmaFactorBS="ttcagccgtccggtttttctgtatttcattGGCATAtcccca agtatcctcaGCATACAATGATTTTCTGTaagcgtttattctacatatgttactccct a" /listShort="S521, yknU, yknV" /listLong="yknW, yknX, yknY, yknZ" /label="upshifts" S_feature 1412080..1412166 /Source="Nicolas_S_feature" /locus_tag="new_1499752_1499838" /HighExp="S4, S5, S3, T5.0H, T4.0H, Pyr, S6, T3.30H, M9-stat, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S521" promotor_-35 1412156..1412159 /Source="Nicolas_upshift_promotors" /id="U1181" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.525474525474525" /psig="0.987012987012987" /xcortree=406 /SigmaFactorBS="ataaagtaagagactcactccataattagactgaaattttga aaaataATAGaaatttatttcgggTATCGATATAGTGAAGATGAtaaatgttggaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1412168 /Source="Nicolas_upshifts" /id="U1181" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.525474525474525" /psig="0.987012987012987" /xcortree=406 /SigmaFactorBS="ataaagtaagagactcactccataattagactgaaattttga aaaataATAGaaatttatttcgggTATCGATATAGTGAAGATGAtaaatgttggaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1412174..1412193 /Source="Nicolas_upshift_promotors" /id="U1181" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.525474525474525" /psig="0.987012987012987" /xcortree=406 /SigmaFactorBS="ataaagtaagagactcactccataattagactgaaattttga aaaataATAGaaatttatttcgggTATCGATATAGTGAAGATGAtaaatgttggaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1412217..1413974 /gene="yknU" /locus_tag="BSU_14320" /old_locus_tag="BSU14320" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_389315.1" /db_xref="EnsemblGenomes-Gn:BSU14320" /db_xref="EnsemblGenomes-Tr:CAB13305" /db_xref="GOA:O31707" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG13241" /db_xref="UniProtKB/Swiss-Prot:O31707" /translation="METFKRLKMYYWPYRKVFMWSLLAMLLMTAITVVYPIILQITID EIVLGRQYQLAAWVSLGFIAVMVLKGMATFFHQYLGDMFGIKSVYRLRNGLYEKLQRL SFSYYDNAKTGDLMSRLTADVEGLRFFLSYGLAELIRFGLLVAISLSVMFYYSVPLTL VTIAVLPFLAVAVYRFDKRVHPAFRGIRKSFAKLNTKVQENISGINTVKSLSREDFQI STFNKANAEYRAQYLQTSSIWSAYFPLMEFIGNTCIVALLSYGGYLVMQNQLNPGELV AFFSLVNYMMWPIMNLGFVINMFSQAKASGERLLDILEKEEDITDHPHALHKQKLTGD VHFKNVSLAYGKEQTNALCNVSFEANSGKVIGLLGPTGSGKSSVTQLLTRFYSPVGGM ITIDHKPITDYSLKTLRSNIGVVLQESFLFSSTIRSNISYGRPDASMEDVIEAAKRAQ AHNFIMELPDGYDTMLGERGMGLSGGQKQRIAIARAICLNPSILILDDATSAVDMQTE HSIQLALKEVMKNRTTFIVAHRISSLKHADEILVFNKGRIRERGTHHELLEKGGYYKK IYDLQYRDVKMINEPHEVG*" /label="yknU CDS" gene 1412217..1413974 /gene="yknU" /locus_tag="BSU_14320" /old_locus_tag="BSU14320" /label="yknU gene" CDS 1413986..1415800 /gene="yknV" /locus_tag="BSU_14330" /old_locus_tag="BSU14330" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_389316.1" /db_xref="EnsemblGenomes-Gn:BSU14330" /db_xref="EnsemblGenomes-Tr:CAB13306" /db_xref="GOA:O31708" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG13242" /db_xref="UniProtKB/Swiss-Prot:O31708" /translation="MKQAKKQGVLERFYYSSDEIIEKPFNWAQMWRLLSYVKPYRKTI LPLSFLTVLIGTAVKLVIPILIGVYVLDQAITGRNSELLIQLIFIISGLYVLNYAANV LRIRWMNQLGQHVIYDLRQHLFTHVQRLSHRFFDQRSAGSILVRIMNDINSLQELFTS GVINLLTDLLLLAGVIIILFTLSPELTIAIMVTLPIMFFISTSLRKKIRRSWQTVRLK QSKLNSHLNESIQGIRVTQAFTQEEENMAYFDGVNQENYESWREATRKNAMFRPLVEM TNAIGTAVLIWYGATLIMNETITIGVFVSFAFYLGMFWEPISRLGQVYNQLLMGMASS ERIFEFLDEQPNVKEKPNAIHNEKINGEISFEEVEFSYDEKRKALHAVSFSIPAGSTL ALVGHTGSGKTTIANLISRFYDAAGGTIKIDGIPIKDLSLASLRSQISIVLQDTFIFS GTIMENIRFGRPNASDEEVMKASQAVGADEFISDLAEGYATEVEERGSVLSAGQRQLI SFARALLADPAIIILDEATASIDTETEVKIQQALKTLLKGRTAVMIAHRLSTIRDADR IIVLDHGRKIEEGNHDQLLAKGGIYAGLVKAQYSTAIE*" /label="yknV CDS" gene 1413986..1415800 /gene="yknV" /locus_tag="BSU_14330" /old_locus_tag="BSU14330" /label="yknV gene" promotor_-10 complement(1414423..1414442) /Source="Nicolas_upshift_promotors" /id="U1182" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.63036963036963" /psig="0.954045954045954" /xcortree=1712 /SigmaFactorBS="gcaagtcggtcaacaaattgatgactccgCTTGTAAAgagct cctgaagagAGTTAATATCATTCATGATCctgactaagatcgatcccgccgaccgctg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1414433) /Source="Nicolas_upshifts" /id="U1182" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.63036963036963" /psig="0.954045954045954" /xcortree=1712 /SigmaFactorBS="gcaagtcggtcaacaaattgatgactccgCTTGTAAAgagct cctgaagagAGTTAATATCATTCATGATCctgactaagatcgatcccgccgaccgctg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1414457..1414464) /Source="Nicolas_upshift_promotors" /id="U1182" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.63036963036963" /psig="0.954045954045954" /xcortree=1712 /SigmaFactorBS="gcaagtcggtcaacaaattgatgactccgCTTGTAAAgagct cctgaagagAGTTAATATCATTCATGATCctgactaagatcgatcccgccgaccgctg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1415851..1415860 /Source="Nicolas_upshift_promotors" /id="U1183" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1690 /SigmaFactorBS="atattgaaggtttttggaaatttattagaaaaacaTGAAACT TTTtgatatccttcCCGTACTATTTGTTAGatattctcaaggaggttttgaaatggaa a" /listShort="yknW, yknX, yknY, yknZ, S522, fruR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1415872..1415887 /Source="Nicolas_upshift_promotors" /id="U1183" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1690 /SigmaFactorBS="atattgaaggtttttggaaatttattagaaaaacaTGAAACT TTTtgatatccttcCCGTACTATTTGTTAGatattctcaaggaggttttgaaatggaa a" /listShort="yknW, yknX, yknY, yknZ, S522, fruR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1415876 /Source="Nicolas_upshifts" /id="U1183" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1690 /SigmaFactorBS="atattgaaggtttttggaaatttattagaaaaacaTGAAACT TTTtgatatccttcCCGTACTATTTGTTAGatattctcaaggaggttttgaaatggaa a" /listShort="yknW, yknX, yknY, yknZ, S522, fruR" /GFF_Attribute="listLong" /label="upshifts" CDS 1415910..1416605 /gene="skiW" /locus_tag="BSU_14340" /old_locus_tag="BSU14340" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 22707703" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 22707703; Product type t: transporter" /codon_start=1 /transl_table=11 /product="subunit of permease exporting the starvation-induced killing protein" /protein_id="NP_389317.1" /db_xref="EnsemblGenomes-Gn:BSU14340" /db_xref="EnsemblGenomes-Tr:CAB13307" /db_xref="GOA:O31709" /db_xref="InterPro:IPR006977" /db_xref="SubtiList:BG13243" /db_xref="UniProtKB/Swiss-Prot:O31709" /translation="METNVEKNSGTATEKPSLFGVITSPSVQFERIRERPAVWGPLLI VAAIIIVGAVLQSLGTDYSELLKSQDTQGLSAEQMETVATITKFGGMAGAIIGGIAAL FIAPLIYWLCVKVSGGVTTYKKMLSLSLFVSLISSLGLLVNGIVAFTTDVNPLYSTTS LAGIIPSDGALASVLNTFEIFSIWSFVLLAIGLHKTGGISKKAGWISAIILFGILVVF SLFSGLINSVAGA*" /label="skiW CDS" gene 1415910..1416605 /gene="skiW" /locus_tag="BSU_14340" /old_locus_tag="BSU14340" /label="skiW gene" CDS 1416610..1417743 /gene="skiX" /locus_tag="BSU_14350" /old_locus_tag="BSU14350" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11544226, 22707703" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11544226, 22707703; Product type t: transporter" /codon_start=1 /transl_table=11 /product="subunit of efflux permease exporting the starvation-induced killing protein" /protein_id="NP_389318.1" /db_xref="EnsemblGenomes-Gn:BSU14350" /db_xref="EnsemblGenomes-Tr:CAB13308" /db_xref="GOA:O31710" /db_xref="InterPro:IPR006143" /db_xref="InterPro:IPR032317" /db_xref="SubtiList:BG13244" /db_xref="UniProtKB/Swiss-Prot:O31710" /translation="MKKVWIGIGIAVIVALFVGINIYRSAAPTSGSAGKEVQTGSVEE NEISSTVMVPGTLKFSNEQYVFYEADKGTLEDIKVKEGDKVKKGTALVTYTNEQLSLE KEQNQLTSESNRLQIDQIQEKLKALDSKERELEKQVGKKEAEKQIESERTELQMQKKT AEIELKQTELQRQSLANRVSDLEVKSEIEGTVISVNQEAASKKSDIQEPVIHIGNPKD LVVSGKLSEYDTLKVKKGQKVTLTSDVIQGKTWKGTVSAVGLVPDQQESAAAQGTEQA VQYPLQVKIKGNLPEGKPGFKFIMNIETDKRKANTLPSKAVKKEDDQYYVYTVKDGKA KRVDVKIGEVTDDLTEIKEGLTQDDQVILNPSDQVTDGMEVKS*" /label="skiX CDS" gene 1416610..1417743 /gene="skiX" /locus_tag="BSU_14350" /old_locus_tag="BSU14350" /label="skiX gene" CDS 1417744..1418436 /gene="skiY" /locus_tag="BSU_14360" /old_locus_tag="BSU14360" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9987136, 22707703" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9987136, 22707703; Product type t: transporter" /codon_start=1 /transl_table=11 /product="subunit of efflux permease exporting the starvation-induced killing protein (ATP-binding protein)" /protein_id="NP_389319.1" /db_xref="EnsemblGenomes-Gn:BSU14360" /db_xref="EnsemblGenomes-Tr:CAB13309" /db_xref="GOA:O31711" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13245" /db_xref="UniProtKB/Swiss-Prot:O31711" /translation="MIQLSNVRKSYQIGKETFDVLHSIDLDIHQGEYVSIMGPSGSGK STIMNIIGCLDRPTSGTYQLDGEDISSYKDKELAAVRNRSIGFVFQQFQLLPRLNAKK NVELPMIYSGIGKKERQERAERALEKVGLADRMLHMPNELSGGQKQRVAIARAIVNEP KLILADEPTGALDTKTSEAIMDQFTALNAEGTTIVLVTHEPEVADCTNRIVMVRDGNI VPASSGQRSVGE*" /label="skiY CDS" gene 1417744..1418436 /gene="skiY" /locus_tag="BSU_14360" /old_locus_tag="BSU14360" /label="skiY gene" CDS 1418433..1419626 /gene="skiZ" /locus_tag="BSU_14370" /old_locus_tag="BSU14370" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9987136, 22707703, 22720735, 27243566" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9987136, 22707703, 22720735, 27243566; Product type t: transporter" /codon_start=1 /transl_table=11 /product="permease subunit exporting Sporulation-Delaying Protein" /protein_id="NP_389320.1" /db_xref="EnsemblGenomes-Gn:BSU14370" /db_xref="EnsemblGenomes-Tr:CAB13310" /db_xref="GOA:O31712" /db_xref="InterPro:IPR003838" /db_xref="InterPro:IPR005085" /db_xref="InterPro:IPR025857" /db_xref="SubtiList:BG13246" /db_xref="UniProtKB/Swiss-Prot:O31712" /translation="MSLLENIRMALSSVLAHKMRSILTMLGIIIGVGSVIVVVAVGQG GEQMLKQSISGPGNTVELYYMPSDEELASNPNAAAESTFTENDIKGLKGIEGIKQVVA STSESMKARYHEEETDATVNGINDGYMNVNSLKIESGRTFTDNDFLAGNRVGIISQKM AKELFDKTSPLGEVVWINGQPVEIIGVLKKVTGLLSFDLSEMYVPFNMMKSSFGTSDF SNVSLQVESADDIKSAGKEAAQLVNDNHGTEDSYQVMNMEEIAAGIGKVTAIMTTIIG SIAGISLLVGGIGVMNIMLVSVTERTREIGIRKSLGATRGQILTQFLIESVVLTLIGG LVGIGIGYGGAALVSAIAGWPSLISWQVVCGGVLFSMLIGVIFGMLPANKAAKLDPIE ALRYE*" /label="skiZ CDS" gene 1418433..1419626 /gene="skiZ" /locus_tag="BSU_14370" /old_locus_tag="BSU14370" /label="skiZ gene" downshifts 1419604 /Source="Nicolas_upshifts" /id="D800" /incds=0 /nref=79 /ntot=210 /MaxReadThrough="3.49546" /MaxDrop="4.46952" /score="36.2703425" /energy="-12.1" /TU="U1183" /idTUdmin="U1183" /TUdmin="-396" /isTUend="FALSE" /label="downshifts" promotor_-35 1419675..1419681 /Source="Nicolas_upshift_promotors" /id="U1184" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.86013986013986" /psig="0.86013986013986" /xcortree=1212 /SigmaFactorBS="tgaggtttttttatgtttagtgatttctactaTGAATATaaa agacttttttCATTAAAATAAGaagaaaatgtcgtacaattgtccttatttttgtcga a" /listShort="S522, fruR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1419695..1419706 /Source="Nicolas_upshift_promotors" /id="U1184" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.86013986013986" /psig="0.86013986013986" /xcortree=1212 /SigmaFactorBS="tgaggtttttttatgtttagtgatttctactaTGAATATaaa agacttttttCATTAAAATAAGaagaaaatgtcgtacaattgtccttatttttgtcga a" /listShort="S522, fruR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1419703 /Source="Nicolas_upshifts" /id="U1184" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.86013986013986" /psig="0.86013986013986" /xcortree=1212 /SigmaFactorBS="tgaggtttttttatgtttagtgatttctactaTGAATATaaa agacttttttCATTAAAATAAGaagaaaatgtcgtacaattgtccttatttttgtcga a" /listShort="S522, fruR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1419748..1419755 /Source="Nicolas_upshift_promotors" /id="U1185" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.87012987012987" /psig="0.967032967032967" /xcortree=1 /SigmaFactorBS="gtcgtacaattgtccttatttttgtcgaatttaCAGTTTACa aaccctatagacaTACGTTAATATGGAGAAACGtgaaagattttgatagttattgaat g" /listShort="S522, fruR, fruK, fruA" /listLong="sipT" /label="promotor_-35" promotor_-10 1419770..1419789 /Source="Nicolas_upshift_promotors" /id="U1185" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.87012987012987" /psig="0.967032967032967" /xcortree=1 /SigmaFactorBS="gtcgtacaattgtccttatttttgtcgaatttaCAGTTTACa aaccctatagacaTACGTTAATATGGAGAAACGtgaaagattttgatagttattgaat g" /listShort="S522, fruR, fruK, fruA" /listLong="sipT" /label="promotor_-10" S_feature 1419775..1419866 /Source="Nicolas_S_feature" /locus_tag="new_1507447_1507538" /HighExp="UNK1, LPh, HPh, Fru, G180, MG 5, C30, G135, MG t5, MG 10" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF, SigWXY" /TUshortPSig="0.967, 0.86, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S522" upshifts 1419775 /Source="Nicolas_upshifts" /id="U1185" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.87012987012987" /psig="0.967032967032967" /xcortree=1 /SigmaFactorBS="gtcgtacaattgtccttatttttgtcgaatttaCAGTTTACa aaccctatagacaTACGTTAATATGGAGAAACGtgaaagattttgatagttattgaat g" /listShort="S522, fruR, fruK, fruA" /listLong="sipT" /label="upshifts" promotor_-35 1419830..1419837 /Source="Nicolas_upshift_promotors" /id="U1186" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.814185814185814" /psig="0.999000999001" /xcortree=2 /SigmaFactorBS="attgaatgaatttgaatgatttTAGTTGCCtaaaccgaaaat aGCGTTTACAATGAAATTGTAttcaaaatgaatacgttttcattaggaggtgaagcat g" /listShort="fruR, fruK, fruA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1419851..1419870 /Source="Nicolas_upshift_promotors" /id="U1186" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.814185814185814" /psig="0.999000999001" /xcortree=2 /SigmaFactorBS="attgaatgaatttgaatgatttTAGTTGCCtaaaccgaaaat aGCGTTTACAATGAAATTGTAttcaaaatgaatacgttttcattaggaggtgaagcat g" /listShort="fruR, fruK, fruA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1419868 /Source="Nicolas_upshifts" /id="U1186" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.814185814185814" /psig="0.999000999001" /xcortree=2 /SigmaFactorBS="attgaatgaatttgaatgatttTAGTTGCCtaaaccgaaaat aGCGTTTACAATGAAATTGTAttcaaaatgaatacgttttcattaggaggtgaagcat g" /listShort="fruR, fruK, fruA" /GFF_Attribute="listLong" /label="upshifts" CDS 1419906..1420661 /gene="fruR" /locus_tag="BSU_14380" /old_locus_tag="BSU14380" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14563858; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (DeoR family)" /protein_id="NP_389321.1" /db_xref="EnsemblGenomes-Gn:BSU14380" /db_xref="EnsemblGenomes-Tr:CAB13311" /db_xref="GOA:O31713" /db_xref="InterPro:IPR001034" /db_xref="InterPro:IPR014036" /db_xref="InterPro:IPR018356" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12589" /db_xref="UniProtKB/Swiss-Prot:O31713" /translation="MLTPERHQLIIDQIEKHDVVKIQELINLTNASESTIRRDLSTLE ERGFLKRVHGGAAKLSDIRLEPDMLEKSSKNLHDKLKIAEKAASLLEEGDCIYLDAGT TTLHMIDFMDKTKDIVVVTNGVMHIDALIRKEISFYLLGGYVKHRTGAIIGGASLVAM DQYRFDKSFLGTNGVHTEAGFTTPDPDEALLKQKAIKQAKHAYVLADPSKFGEISFSA FAGIGDATIITTDAEELTFDNYQEKTVVKVVKP*" /label="fruR CDS" gene 1419906..1420661 /gene="fruR" /locus_tag="BSU_14380" /old_locus_tag="BSU14380" /label="fruR gene" upshifts complement(1420054) /Source="Nicolas_upshifts" /id="U1187" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.74925074925075" /psig="0.015984015984016" /xcortree=3 /SigmaFactorBS="tcaagcatatcgggttcaagtctgatatcggaaagcttGgcc gctccaccatgaacGCGctttaaaaaaccgcgttcttcaagggtcgataaatctcttc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1420056..1420058) /Source="Nicolas_upshift_promotors" /id="U1187" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.74925074925075" /psig="0.015984015984016" /xcortree=3 /SigmaFactorBS="tcaagcatatcgggttcaagtctgatatcggaaagcttGgcc gctccaccatgaacGCGctttaaaaaaccgcgttcttcaagggtcgataaatctcttc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1420658..1421569 /gene="fruK" /locus_tag="BSU_14390" /old_locus_tag="BSU14390" /EC_number="2.7.1.56" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 168069, 14563858, 24328040; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fructose-1-phosphate kinase" /protein_id="NP_389322.1" /db_xref="EnsemblGenomes-Gn:BSU14390" /db_xref="EnsemblGenomes-Tr:CAB13312" /db_xref="GOA:O31714" /db_xref="InterPro:IPR002173" /db_xref="InterPro:IPR011611" /db_xref="InterPro:IPR017583" /db_xref="InterPro:IPR022463" /db_xref="InterPro:IPR023314" /db_xref="InterPro:IPR029056" /db_xref="SubtiList:BG12588" /db_xref="UniProtKB/Swiss-Prot:O31714" /translation="MIYTVTLNPSVDYIVHVEDFTVGGLNRSSYDTKYPGGKGINVSR LLKRHHVASKALGFVGGFTGEYIKTFLREENLETAFSEVKGDTRINVKLKTGDETEIN GQGPTISDEDFKAFLEQFQSLQEGDIVVLAGSIPSSLPHDTYEKIAEACKQQNARVVL DISGEALLKATEMKPFLMKPNHHELGEMFGTAITSVEEAVPYGKKLVEQGAEHVIVSM AGDGALLFTNEAVYFANVPKGKLVNSVGAGDSVVAGFLAGISKQLPLEEAFRLGVTSG SATAFSEELGTEEFVQQLLPEVKVTRL*" /label="fruK CDS" gene 1420658..1421569 /gene="fruK" /locus_tag="BSU_14390" /old_locus_tag="BSU14390" /label="fruK gene" CDS 1421584..1423491 /gene="fruA" /locus_tag="BSU_14400" /old_locus_tag="BSU14400" /EC_number="2.7.1.202" /function="16.11: Scavenge (Catabolism)" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:118007, 200418" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 118007, 200418; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) fructose-specific enzyme IIABC component" /protein_id="NP_389323.1" /db_xref="EnsemblGenomes-Gn:BSU14400" /db_xref="EnsemblGenomes-Tr:CAB13313" /db_xref="GOA:P71012" /db_xref="InterPro:IPR002178" /db_xref="InterPro:IPR003353" /db_xref="InterPro:IPR003501" /db_xref="InterPro:IPR004715" /db_xref="InterPro:IPR006327" /db_xref="InterPro:IPR013011" /db_xref="InterPro:IPR013014" /db_xref="InterPro:IPR016152" /db_xref="InterPro:IPR036095" /db_xref="PDB:2R4Q" /db_xref="SubtiList:BG11938" /db_xref="UniProtKB/Swiss-Prot:P71012" /translation="MKITELLTKHTIKLNIESKEKENVIDEMVTVLDKAGKLNDRQAY KEAILNRESQSSTGIGEGIAIPHAKTASVINPAIAFGRSKDGVDYESLDGQPAHLVFM IAATEGANNTHLEALSRLSTLLMREEIRKQLLEAESEDAIIDIINQHDKDDDEEEEEE EAAPAPAGKGKILAVTACPTGIAHTFMAADALKEKAKELGVEIKVETNGSSGIKHKLT AQEIEDAPAIIVAADKQVEMERFKGKRVLQVPVTAGIRRPQELIEKAMNQDAPIYQGS GGGSAASNDDEEAKGKSGSGIGNTFYKHLMSGVSNMLPFVVGGGILVAISFFWGIHSA DPNDPSYNTFAAALNFIGGDNALKLIVAVLAGFIAMSIADRPGFAPGMVGGFMATQAN AGFLGGLIAGFLAGYVVILLKKVFTFIPQSLDGLKPVLIYPLFGIFITGVLMQFVVNT PVAAFMNFLTNWLESLGTGNLVLMGIILGGMMAIDMGGPLNKAAFTFGIAMIDAGNYA PHAAIMAGGMVPPLGIALATTIFRNKFTQRDREAGITCYFMGAAFVTEGAIPFAAADP LRVIPAAVVGAAVAGGLTEFFRVTLPAPHGGVFVAFITNHPMLYLLSIVIGAVVMAII LGIVKKPVTEK*" /label="fruA CDS" gene 1421584..1423491 /gene="fruA" /locus_tag="BSU_14400" /old_locus_tag="BSU14400" /label="fruA gene" downshifts 1423476 /Source="Nicolas_upshifts" /id="D801" /incds=0 /nref=133 /ntot=228 /MaxReadThrough="3.99928" /MaxDrop="5.27169" /score="11.7516734" /energy="-11.4" /TU="U1185" /idTUdmin="U1186" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1423560..1423567 /Source="Nicolas_upshift_promotors" /id="U1188" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=1910 /SigmaFactorBS="gctttttcttatccggccggcagggagcgcggttaagttATG TATTTtattctttttTATGATAAAGTAAAAGAAGAgaaacaactgacatagcaattgt c" /listShort="sipT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1423578..1423597 /Source="Nicolas_upshift_promotors" /id="U1188" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=1910 /SigmaFactorBS="gctttttcttatccggccggcagggagcgcggttaagttATG TATTTtattctttttTATGATAAAGTAAAAGAAGAgaaacaactgacatagcaattgt c" /listShort="sipT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1423581 /Source="Nicolas_upshifts" /id="U1188" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=1910 /SigmaFactorBS="gctttttcttatccggccggcagggagcgcggttaagttATG TATTTtattctttttTATGATAAAGTAAAAGAAGAgaaacaactgacatagcaattgt c" /listShort="sipT" /GFF_Attribute="listLong" /label="upshifts" CDS 1423636..1424217 /gene="sipT" /locus_tag="BSU_14410" /old_locus_tag="BSU14410" /EC_number="3.4.21.89" /function="16.1: Circulate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9325333, 10198007, 11283286, 11807061, 12897006, 27159567" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9325333, 10198007, 11283286, 11807061, 12897006, 27159567; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="type I signal peptidase" /protein_id="NP_389324.1" /db_xref="EnsemblGenomes-Gn:BSU14410" /db_xref="EnsemblGenomes-Tr:CAB13314" /db_xref="GOA:P71013" /db_xref="InterPro:IPR000223" /db_xref="InterPro:IPR015927" /db_xref="InterPro:IPR019756" /db_xref="InterPro:IPR019757" /db_xref="InterPro:IPR019758" /db_xref="InterPro:IPR036286" /db_xref="SubtiList:BG11977" /db_xref="UniProtKB/Swiss-Prot:P71013" /translation="MTEEKNTNTEKTAKKKTNTYLEWGKAIVIAVLLALLIRHFLFEP YLVEGSSMYPTLHDGERLFVNKTVNYIGELKRGDIVIINGETSKIHYVKRLIGKPGET VQMKDDTLYINGKKVAEPYLSKNKKEAEKLGVSLTGDFGPVKVPKGKYFVMGDNRLNS MDSRNGLGLIAEDRIVGTSKFVFFPFNEMRQTK*" /label="sipT CDS" gene 1423636..1424217 /gene="sipT" /locus_tag="BSU_14410" /old_locus_tag="BSU14410" /label="sipT gene" downshifts 1424202 /Source="Nicolas_upshifts" /id="D802" /incds=0 /nref=90 /ntot=226 /MaxReadThrough="3.7981" /MaxDrop="6.13957" /score="5.03270493" /energy="-9.8" /TU="U1188" /idTUdmin="U1188" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" downshifts 1424246 /Source="Nicolas_upshifts" /id="D803" /incds=0 /nref=1 /ntot=29 /MaxReadThrough="2.6676" /MaxDrop="3.60225" /score="5.03270493" /energy="-9.8" /TU="NA" /idTUdmin="U1188" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1424251..1424520) /gene="ykoA" /locus_tag="BSU_14420" /old_locus_tag="BSU14420" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein of unknown function" /protein_id="NP_389325.1" /db_xref="EnsemblGenomes-Gn:BSU14420" /db_xref="EnsemblGenomes-Tr:CAB13315" /db_xref="GOA:O31715" /db_xref="SubtiList:BG13247" /db_xref="UniProtKB/Swiss-Prot:O31715" /translation="MRLLTLTEYCLLIFFTGFYLAVTGFTAKDIGLYIGIALIYIFSH IFSKRLLEKRGKENKQVHLFFSVLAIIGSVFITVLCIALVASFSK*" /label="ykoA CDS" gene complement(1424251..1424520) /gene="ykoA" /locus_tag="BSU_14420" /old_locus_tag="BSU14420" /label="ykoA gene" downshifts complement(1424256) /Source="Nicolas_upshifts" /id="D804" /incds=0 /nref=38 /ntot=254 /MaxReadThrough="2.08491" /MaxDrop="5.70938" /score="11.210199" /energy="-9.8" /TU="U1189" /idTUdmin="U1189" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" S_feature complement(1424521..1424586) /Source="Nicolas_S_feature" /locus_tag="new_1512193_1512258_c" /HighExp="LoTm, Gly, Lbstat, Sw, Cold, C30, HPh, S0, T0.30H, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S523" misc_feature complement(1424567..1424586) /Source="Nicolas_upshift_promotors" /id="U1189" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.85914085914086" /psig="0.999000999001" /xcortree=2176 /SigmaFactorBS="aagagaaatgattccctgataaaacagagagaaaacacttat acacccaaaccagccagcTGTGTTACAATTAAAGAGAGagaatgcatccgcctggaaa a" /listShort="S523, ykoA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1424586) /Source="Nicolas_upshifts" /id="U1189" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.85914085914086" /psig="0.999000999001" /xcortree=2176 /SigmaFactorBS="aagagaaatgattccctgataaaacagagagaaaacacttat acacccaaaccagccagcTGTGTTACAATTAAAGAGAGagaatgcatccgcctggaaa a" /listShort="S523, ykoA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1424639..1424646 /Source="Nicolas_upshift_promotors" /id="U1190" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2141 /SigmaFactorBS="gtgtataagtgttttctctctgttttatcagggaatcaTTTC TCTTgccctgcattCATGGTATACTTTTATTGATgatagacatgatggaggataataa a" /listShort="ykpA, panE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1424657..1424676 /Source="Nicolas_upshift_promotors" /id="U1190" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2141 /SigmaFactorBS="gtgtataagtgttttctctctgttttatcagggaatcaTTTC TCTTgccctgcattCATGGTATACTTTTATTGATgatagacatgatggaggataataa a" /listShort="ykpA, panE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1424661 /Source="Nicolas_upshifts" /id="U1190" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2141 /SigmaFactorBS="gtgtataagtgttttctctctgttttatcagggaatcaTTTC TCTTgccctgcattCATGGTATACTTTTATTGATgatagacatgatggaggataataa a" /listShort="ykpA, panE" /GFF_Attribute="listLong" /label="upshifts" CDS 1424701..1426323 /gene="ykpA" /locus_tag="BSU_14430" /old_locus_tag="BSU14430" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10816464, 24389466; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative energy-sensing inhibitor of translation" /protein_id="NP_389326.1" /db_xref="EnsemblGenomes-Gn:BSU14430" /db_xref="EnsemblGenomes-Tr:CAB13316" /db_xref="GOA:O31716" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR032781" /db_xref="SubtiList:BG13270" /db_xref="UniProtKB/Swiss-Prot:O31716" /translation="MIAVNNVSLRFADRKLFEDVNIKFTPGNCYGLIGANGAGKSTFL KVLSGEIEPQTGDVHMSPGERLAVLKQNHFEYEEYEVLKVVIMGHKRLYEVMQEKDAI YMKPDFSDEDGIRAAELEGEFAELNGWEAESEAAILLKGLGISEDLHTKKMADLGGSE KVKVLLAQALFGKPDVLLLDEPTNHLDLQAIQWLEEFLINFENTVIVVSHDRHFLNKV CTHIADLDFNKIQIYVGNYDFWYESSQLALKLSQEANKKKEEQIKQLQEFVARFSANA SKSKQATSRKKLLEKITLDDIKPSSRRYPYVNFTPEREIGNDVLRVEGLTKTIDGVKV LDNVSFIMNREDKIAFTGRNELAVTTLFKIISGEMEADSGTFKWGVTTSQAYFPKDNS EYFEGSDLNLVDWLRQYSPHDQSESFLRGFLGRMLFSGEEVHKKANVLSGGEKVRCML SKAMLSGANILILDEPTNHLDLESITALNNGLISFKGAMLFTSHDHQFVQTIANRIIE ITPNGIVDKQMSYDEFLENADVQKKLTELYAE*" /label="ykpA CDS" gene 1424701..1426323 /gene="ykpA" /locus_tag="BSU_14430" /old_locus_tag="BSU14430" /label="ykpA gene" downshifts 1426311 /Source="Nicolas_upshifts" /id="D805" /incds=0 /nref=45 /ntot=239 /MaxReadThrough="5.13671" /MaxDrop="3.6227" /score="17.6386925" /energy="-7.6" /TU="U1190" /idTUdmin="U1190" /TUdmin="-993" /isTUend="FALSE" /label="downshifts" CDS 1426380..1427291 /gene="panE" /locus_tag="BSU_14440" /old_locus_tag="BSU14440" /EC_number="1.1.1.169" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1844812, 15966718, 17229734; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-dehydropantoate reductase" /protein_id="NP_389327.1" /db_xref="EnsemblGenomes-Gn:BSU14440" /db_xref="EnsemblGenomes-Tr:CAB13317" /db_xref="GOA:O31717" /db_xref="InterPro:IPR003710" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR013332" /db_xref="InterPro:IPR013752" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13271" /db_xref="UniProtKB/Swiss-Prot:O31717" /translation="MKFLVVGAGGVGGYIGGRLSEKGNDVTFLVRQKRAEQLKKTGLV IHSEKGNVSFQPELISAGETGQFDVVIIASKAYSLGQVIEDVKPFIHQESVIIPFLNG YRHYEQLFAAFSKEQVLGGLCFIESALDNKGEIHHTSASHRFVFGEWNGERTERIRAL EEAFSGVKAEVIISGHIEKDIWKKYLFIAAQAGITTLFQRPLGPILATEAGRHTAQTL IGEICTVLRKEGVPADPALEEESFRTMTSMSYHMKSSMLRDMENGQTTEGDHLHGFLI EKAKRLSLAAPVLETVYANLQMYEAEK*" /label="panE CDS" gene 1426380..1427291 /gene="panE" /locus_tag="BSU_14440" /old_locus_tag="BSU14440" /label="panE gene" downshifts 1427296 /Source="Nicolas_upshifts" /id="D806" /incds=0 /nref=120 /ntot=228 /MaxReadThrough="2.04919" /MaxDrop="4.55439" /score="11.4959806" /energy="-9.6" /TU="NA" /idTUdmin="U1190" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" CDS complement(1427325..1428557) /gene="ampS" /locus_tag="BSU_14450" /old_locus_tag="BSU14450" /EC_number="3.4.11.24" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9362117, 16088219, 22808738" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9362117, 16088219, 22808738; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aminopeptidase" /protein_id="NP_389328.1" /db_xref="EnsemblGenomes-Gn:BSU14450" /db_xref="EnsemblGenomes-Tr:CAB13318" /db_xref="GOA:P39762" /db_xref="InterPro:IPR000787" /db_xref="InterPro:IPR035097" /db_xref="SubtiList:BG10986" /db_xref="UniProtKB/Swiss-Prot:P39762" /translation="MDSFSQKLNTYAQLAVEVGVNVQKGQYVVVNASTDVRDFVRLIV KHAYEKGAKNVTVNWQDDEVAKLKYELAPFEAFEEYPEWEAKGREELAKNGAAFISVV SSNPDLLKGIDSKRIAAFQKAAGKALHTYRQYIQSDKVSWTVVGAASAGWAHKVFPGK SEEEAIHLLWEEIFKATRVNEDNPVQAWINHDQNLHEKVDHLNERHYAALHYQAEGTD LTIKLPRKHVWAGAGSVNESGHEFMANMPTEEVFTLPQKDGVDGVVSSTKPLSYGGNI IENFTLTFENGRIVDIKAEKGEDILKELVETDEGSHYLGEVALVPYDSPISQSNILFY NTLFDENASNHLAIGSAYAFNIEGGKQMSREELVKEGLNESITHVDFMIGSKDMNIDG ITADGKREPIFRNGNWAF*" /label="ampS CDS" gene complement(1427325..1428557) /gene="ampS" /locus_tag="BSU_14450" /old_locus_tag="BSU14450" /label="ampS gene" downshifts complement(1427336) /Source="Nicolas_upshifts" /id="D807" /incds=0 /nref=215 /ntot=254 /MaxReadThrough="1.34101" /MaxDrop="5.7635" /score="40.7811053" /energy="-9.6" /TU="NA" /idTUdmin="U1191" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1428575..1428594) /Source="Nicolas_upshift_promotors" /id="U1191" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.454545454545455" /psig="0.982017982017982" /xcortree=2338 /SigmaFactorBS="aaaacccaagacgtgtcgttttgggtttttcactttgggctc cttCTTTCCtttataggatcataTTTGATATGATGAGAAAAAAgcttggaggaatgat t" /listShort="ampS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1428599) /Source="Nicolas_upshifts" /id="U1191" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.454545454545455" /psig="0.982017982017982" /xcortree=2338 /SigmaFactorBS="aaaacccaagacgtgtcgttttgggtttttcactttgggctc cttCTTTCCtttataggatcataTTTGATATGATGAGAAAAAAgcttggaggaatgat t" /listShort="ampS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1428609..1428614) /Source="Nicolas_upshift_promotors" /id="U1191" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.454545454545455" /psig="0.982017982017982" /xcortree=2338 /SigmaFactorBS="aaaacccaagacgtgtcgttttgggtttttcactttgggctc cttCTTTCCtttataggatcataTTTGATATGATGAGAAAAAAgcttggaggaatgat t" /listShort="ampS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1428667..1428801) /gene="ykpC" /locus_tag="BSU_14460" /old_locus_tag="BSU14460" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389329.1" /db_xref="EnsemblGenomes-Gn:BSU14460" /db_xref="EnsemblGenomes-Tr:CAB13319" /db_xref="InterPro:IPR035379" /db_xref="SubtiList:BG11812" /db_xref="UniProtKB/Swiss-Prot:Q45492" /translation="MLRDLGRRVAIAAILSGIILGGMSISLANMPHSPAGGTVKLNHP *" /label="ykpC CDS" gene complement(1428667..1428801) /gene="ykpC" /locus_tag="BSU_14460" /old_locus_tag="BSU14460" /label="ykpC gene" downshifts complement(1428678) /Source="Nicolas_upshifts" /id="D808" /incds=0 /nref=51 /ntot=151 /MaxReadThrough="3.10365" /MaxDrop="5.04142" /score="-2.2377884" /energy="-9.1" /TU="U1192" /idTUdmin="U1193" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1428823..1428841) /Source="Nicolas_upshift_promotors" /id="U1192" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.863136863136863" /psig="0.863136863136863" /xcortree=1021 /SigmaFactorBS="ccgcaaaattctcacacgcggcaaatttcttgCTTCTTtttt cctcacttcctTCATATTGTGGGAAATGGAgaaacgttaaggaggaaacagatgctaa g" /listShort="ykpC, ampS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1428834) /Source="Nicolas_upshifts" /id="U1192" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.863136863136863" /psig="0.863136863136863" /xcortree=1021 /SigmaFactorBS="ccgcaaaattctcacacgcggcaaatttcttgCTTCTTtttt cctcacttcctTCATATTGTGGGAAATGGAgaaacgttaaggaggaaacagatgctaa g" /listShort="ykpC, ampS" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1428836..1428901) /Source="Nicolas_S_feature" /locus_tag="new_1516508_1516573_c" /HighExp="HiTm, C30, Lbstat, MG-0.2, BC, G135, MG 15, MG 10, MG-0.1, MG 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigI" /TUshortPSig="0.982" /TUlongSig="NA" /TUlongPSig="NA" /label="S524" promotor_-35 complement(1428857..1428862) /Source="Nicolas_upshift_promotors" /id="U1192" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.863136863136863" /psig="0.863136863136863" /xcortree=1021 /SigmaFactorBS="ccgcaaaattctcacacgcggcaaatttcttgCTTCTTtttt cctcacttcctTCATATTGTGGGAAATGGAgaaacgttaaggaggaaacagatgctaa g" /listShort="ykpC, ampS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1428902..1429909) /gene="mreBH" /locus_tag="BSU_14470" /old_locus_tag="BSU14470" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16950129, 19643765, 19659933, 21091501, 21636651, 26091431" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16950129, 19643765, 19659933, 21091501, 21636651, 26091431; Product type f : factor" /codon_start=1 /transl_table=11 /product="cell-shape determining protein" /protein_id="NP_389330.1" /db_xref="EnsemblGenomes-Gn:BSU14470" /db_xref="EnsemblGenomes-Tr:CAB13320" /db_xref="GOA:P39763" /db_xref="InterPro:IPR004753" /db_xref="SubtiList:BG10987" /db_xref="UniProtKB/Swiss-Prot:P39763" /translation="MFQSTEIGIDLGTANILVYSKNKGIILNEPSVVAVDTTTKAVLA IGADAKNMIGKTPGKIVAVRPMKDGVIADYDMTTDLLKHIMKKAAKSIGMSFRKPNVV VCTPSGSTAVERRAISDAVKNCGAKNVHLIEEPVAAAIGADLPVDEPVANVVVDIGGG TTEVAIISFGGVVSCHSIRIGGDQLDEDIVSFVRKKYNLLIGERTAEQVKMEIGHALI EHIPEAMEIRGRDLVTGLPKTIMLQSNEIQDAMRESLLHILEAIRATLEDCPPELSGD IVDRGVILTGGGALLNGIKEWLTEEIVVPVHVAQNPLESVAIGTGRSLEVIDKLQKAI K*" /label="mreBH CDS" gene complement(1428902..1429909) /gene="mreBH" /locus_tag="BSU_14470" /old_locus_tag="BSU14470" /label="mreBH gene" upshifts complement(1429955) /Source="Nicolas_upshifts" /id="U1193" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=1772 /SigmaFactorBS="ttacaaaaacatttctttaccgacgcacaCCCCCAAAAatcg cagtatttcTGAGAAACTttaaatgtagaatcatattaaattaggatagagattgggt g" /listShort="mreBH, S524, ykpC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1429956..1429964) /Source="Nicolas_upshift_promotors" /id="U1193" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=1772 /SigmaFactorBS="ttacaaaaacatttctttaccgacgcacaCCCCCAAAAatcg cagtatttcTGAGAAACTttaaatgtagaatcatattaaattaggatagagattgggt g" /listShort="mreBH, S524, ykpC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1429978..1429986) /Source="Nicolas_upshift_promotors" /id="U1193" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=1772 /SigmaFactorBS="ttacaaaaacatttctttaccgacgcacaCCCCCAAAAatcg cagtatttcTGAGAAACTttaaatgtagaatcatattaaattaggatagagattgggt g" /listShort="mreBH, S524, ykpC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1430096..1430105 /Source="Nicolas_upshift_promotors" /id="U1194" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp="0.88011988011988" /psig="0.88011988011988" /xcortree=1803 /SigmaFactorBS="ttttatggaaaaaatatcttgtaattcttatagaaagcgGGA AACTTTTtcaaagtttcatTCGTCTACGATATATTgaggtacatccttaaaacattac a" /listShort="S525, abh, S527" /listLong="kinC, ykqA, ktrC" /label="promotor_-35" upshifts 1430117 /Source="Nicolas_upshifts" /id="U1194" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp="0.88011988011988" /psig="0.88011988011988" /xcortree=1803 /SigmaFactorBS="ttttatggaaaaaatatcttgtaattcttatagaaagcgGGA AACTTTTtcaaagtttcatTCGTCTACGATATATTgaggtacatccttaaaacattac a" /listShort="S525, abh, S527" /listLong="kinC, ykqA, ktrC" /label="upshifts" promotor_-10 1430118..1430133 /Source="Nicolas_upshift_promotors" /id="U1194" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp="0.88011988011988" /psig="0.88011988011988" /xcortree=1803 /SigmaFactorBS="ttttatggaaaaaatatcttgtaattcttatagaaagcgGGA AACTTTTtcaaagtttcatTCGTCTACGATATATTgaggtacatccttaaaacattac a" /listShort="S525, abh, S527" /listLong="kinC, ykqA, ktrC" /label="promotor_-10" S_feature 1430120..1430192 /Source="Nicolas_S_feature" /locus_tag="new_1517792_1517864" /HighExp="Lbexp, dia5, LBGexp, dia0, Lbtran, Mt0, Oxctl, Paraq, M0t45, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.88" /TUlongSig="NA" /TUlongPSig="NA" /label="S525" CDS 1430193..1430471 /gene="abhA" /locus_tag="BSU_14480" /old_locus_tag="BSU14480" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16159768, 17720793, 19767430, 20817675, 20844865" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16159768, 17720793, 19767430, 20817675, 20844865; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator" /protein_id="NP_389331.1" /db_xref="EnsemblGenomes-Gn:BSU14480" /db_xref="EnsemblGenomes-Tr:CAB13321" /db_xref="GOA:P39758" /db_xref="InterPro:IPR007159" /db_xref="PDB:2FY9" /db_xref="PDB:2RO3" /db_xref="SubtiList:BG10988" /db_xref="UniProtKB/Swiss-Prot:P39758" /translation="MKSIGVVRKVDELGRIVMPIELRRALDIAIKDSIEFFVDGDKII LKKYKPHGVCLMTGEITSENKEYGNGKITLSPEGAQLLLEEIQAALKE*" /label="abhA CDS" gene 1430193..1430471 /gene="abhA" /locus_tag="BSU_14480" /old_locus_tag="BSU14480" /label="abhA gene" downshifts 1430469 /Source="Nicolas_upshifts" /id="D809" /incds=0 /nref=61 /ntot=238 /MaxReadThrough="4.68201" /MaxDrop="5.62457" /score="7.91393519" /energy="-11" /TU="U1194" /idTUdmin="U1194" /TUdmin="-135" /isTUend="FALSE" /label="downshifts" S_feature complement(1430503..1432132) /Source="Nicolas_S_feature" /locus_tag="new_1518175_1519804_c" /HighExp="S6, S8, S5, LoTm, S4, S7, S3, C30, T5.0H, BT" /AntisenseName="kinC" /AntisenseCor="-0.76370141168998495" /AntisenseRegPval="-51.9" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S526" S_feature 1430514..1430618 /Source="Nicolas_S_feature" /locus_tag="new_1518186_1518290" /HighExp="Oxctl, Lbexp, LBGexp, H2O2, dia0, Paraq, G180, G150, G135, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.88" /TUlongSig="NA" /TUlongPSig="NA" /label="S527" downshifts complement(1430526) /Source="Nicolas_upshifts" /id="D810" /incds=0 /nref=1 /ntot=22 /MaxReadThrough="0.833919999999999" /MaxDrop="3.11258" /score="8.02057524" /energy="-11" /TU="NA" /idTUdmin="U1196" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1430600..1430607 /Source="Nicolas_upshift_promotors" /id="U1195" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2153 /SigmaFactorBS="atatttggtaatgaatgatttgggatactttacatattttAC TCAATTatttgtcgaagAATGGTACAATAAGTAGAGAaacacaagcggcaggtggtca t" /listShort="kinC, ykqA, ktrC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1430619..1430638 /Source="Nicolas_upshift_promotors" /id="U1195" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2153 /SigmaFactorBS="atatttggtaatgaatgatttgggatactttacatattttAC TCAATTatttgtcgaagAATGGTACAATAAGTAGAGAaacacaagcggcaggtggtca t" /listShort="kinC, ykqA, ktrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1430620 /Source="Nicolas_upshifts" /id="U1195" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=2153 /SigmaFactorBS="atatttggtaatgaatgatttgggatactttacatattttAC TCAATTatttgtcgaagAATGGTACAATAAGTAGAGAaacacaagcggcaggtggtca t" /listShort="kinC, ykqA, ktrC" /GFF_Attribute="listLong" /label="upshifts" CDS 1430661..1431947 /gene="kinC" /locus_tag="BSU_14490" /old_locus_tag="BSU14490" /EC_number="2.7.13.3" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11069677, 11673427, 7836330, 20971918, 25701730, 26152584, 23569226, 26297017" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11069677, 11673427, 7836330, 20971918, 25701730, 26152584, 23569226, 26297017; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="two-component sensor potassium-responsive histidine kinase regulating cannibalism and biofilm formation" /protein_id="NP_389332.1" /db_xref="EnsemblGenomes-Gn:BSU14490" /db_xref="EnsemblGenomes-Tr:CAB13322" /db_xref="GOA:P39764" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR000700" /db_xref="InterPro:IPR001610" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR013767" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG10989" /db_xref="UniProtKB/Swiss-Prot:P39764" /translation="MRKYQARIISIILAMIFIMFWDYLFYFIGKNPINWPVDIVYTAV TLVSVWMLAYYIDEKQQLVKKMKDNEWKYKQLSEEKNRIMDNLQEIVFQTNAKGEITY LNQAWASITGFSISECMGTMYNDYFIKEKHVADHINTQIQNKASSGMFTAKYVTKNGT IFWGEVHYKLYYDRDDQFTGSLGTMSDITERKEAEDELIEINERLARESQKLSITSEL AAGIAHEVRNPLTSVSGFLQIMKTQYPDRKDYFDIIFSEIKRIDLVLSELLLLAKPQA ITFKTHQLNEILKQVTTLLDTNAILSNIVIEKNFKETDGCMINGDENQLKQVFINIIK NGIEAMPKGGVVTISTAKTASHAVISVKDEGNGMPQEKLKQIGKPFYSTKEKGTGLGL PICLRILKEHDGELKIESEAGKGSVFQVVLPLKSDS*" /label="kinC CDS" gene 1430661..1431947 /gene="kinC" /locus_tag="BSU_14490" /old_locus_tag="BSU14490" /label="kinC gene" CDS 1431963..1432796 /gene="ykqA" /locus_tag="BSU_14500" /old_locus_tag="BSU14500" /EC_number="2.3.2.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 28537416; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative gamma-glutamylcyclotransferase (bacillithiol degradation)" /protein_id="NP_389333.1" /db_xref="EnsemblGenomes-Gn:BSU14500" /db_xref="EnsemblGenomes-Tr:CAB13323" /db_xref="GOA:P39759" /db_xref="InterPro:IPR009288" /db_xref="InterPro:IPR013024" /db_xref="InterPro:IPR036568" /db_xref="PDB:2QIK" /db_xref="SubtiList:BG10990" /db_xref="UniProtKB/Swiss-Prot:P39759" /translation="MNSLLFVYGTLRKHEKNHHLLAQSACINEQARTKGSLFAAKEGP TVVFNDEDEGYIYGEVYEADELCIHKLDQFFQGYHKQTVFVETDVGIKIALIYFMNKD GCAGFTKISSGDWKEHQMISKSKNPIYYFAYGSCMDNARFQKAGVDHYFQDPVGRAVL KGYTTRFTLKREDGSRADMLEDGGTTEGVLYRIPYSALSYLYKREGVESLTYRPAFVD VEAGGRHYKDCLTFLVLQKEAEIAPPQHYQIEIERGAELYLSPEFTEKLKRHMNSLPK G*" /label="ykqA CDS" gene 1431963..1432796 /gene="ykqA" /locus_tag="BSU_14500" /old_locus_tag="BSU14500" /label="ykqA gene" promotor_-10 complement(1432129..1432147) /Source="Nicolas_upshift_promotors" /id="U1196" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1080 /SigmaFactorBS="tgtttatgatatccttgaaaaaattgatcgagcttaTGTATA cacaattcatctgctTCATATACTTCGCCATATAtatagccttcatcttcatcattga a" /listShort="S526" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1432144) /Source="Nicolas_upshifts" /id="U1196" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1080 /SigmaFactorBS="tgtttatgatatccttgaaaaaattgatcgagcttaTGTATA cacaattcatctgctTCATATACTTCGCCATATAtatagccttcatcttcatcattga a" /listShort="S526" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1432163..1432168) /Source="Nicolas_upshift_promotors" /id="U1196" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1080 /SigmaFactorBS="tgtttatgatatccttgaaaaaattgatcgagcttaTGTATA cacaattcatctgctTCATATACTTCGCCATATAtatagccttcatcttcatcattga a" /listShort="S526" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1432859..1433524 /gene="ktrC" /locus_tag="BSU_14510" /old_locus_tag="BSU14510" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12562800, 15096624, 22720735, 23963175, 28420751" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12562800, 15096624, 22720735, 23963175, 28420751; Product type t : transporter" /codon_start=1 /transl_table=11 /product="potassium uptake protein" /protein_id="NP_389334.1" /db_xref="EnsemblGenomes-Gn:BSU14510" /db_xref="EnsemblGenomes-Tr:CAB13324" /db_xref="GOA:P39760" /db_xref="InterPro:IPR003148" /db_xref="InterPro:IPR006037" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR036721" /db_xref="SubtiList:BG10991" /db_xref="UniProtKB/Swiss-Prot:P39760" /translation="MKKEFAVIGLGRFGGSICKALSEEGVEVMAMDIDEDKVNEYAKI ASHAVIGDSTDESVLKNLGLRNFDHVIVAIGENIQASILTTLILKELGVHTITVKAQN DYHEKVLSKIGADHIVHPERDMAKRIAHNIVSNNVLDYLELSEEHSLVEIVANSRLAG NTLLDLDIRAKYGINIVAIKRGKEVIVSPLATEVIHQEDILIVIGSVTDISRFEKRVL HTK*" /label="ktrC CDS" gene 1432859..1433524 /gene="ktrC" /locus_tag="BSU_14510" /old_locus_tag="BSU14510" /label="ktrC gene" downshifts 1433508 /Source="Nicolas_upshifts" /id="D811" /incds=0 /nref=191 /ntot=256 /MaxReadThrough="3.15176" /MaxDrop="5.50828" /score="4.60161255" /energy="-8.2" /TU="U1195" /idTUdmin="U1195" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" promotor_-35 1433615..1433621 /Source="Nicolas_upshift_promotors" /id="U1197" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.305694305694306" /psig="0.861138861138861" /xcortree=2383 /SigmaFactorBS="aactgagcgtcaatttcttaaaatttcATTGACTaagcacag gcgttcCGATAGCATATTGTACCATAtaataaaaaaaggaggggcctatttgaataaa g" /listShort="adeC" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(1433636..1433655) /Source="Nicolas_upshift_promotors" /id="U1198" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.584415584415584" /psig="0.985014985014985" /xcortree=1841 /SigmaFactorBS="ttcagcctattgactagcgcttctttattcaaataggcccct cctttttttattaTATGGTACAATATGCTATCGgaacgcctgtgcttagtcaatgaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 1433636..1433655 /Source="Nicolas_upshift_promotors" /id="U1197" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.305694305694306" /psig="0.861138861138861" /xcortree=2383 /SigmaFactorBS="aactgagcgtcaatttcttaaaatttcATTGACTaagcacag gcgttcCGATAGCATATTGTACCATAtaataaaaaaaggaggggcctatttgaataaa g" /listShort="adeC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1433648 /Source="Nicolas_upshifts" /id="U1197" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.305694305694306" /psig="0.861138861138861" /xcortree=2383 /SigmaFactorBS="aactgagcgtcaatttcttaaaatttcATTGACTaagcacag gcgttcCGATAGCATATTGTACCATAtaataaaaaaaggaggggcctatttgaataaa g" /listShort="adeC" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1433650) /Source="Nicolas_upshifts" /id="U1198" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.584415584415584" /psig="0.985014985014985" /xcortree=1841 /SigmaFactorBS="ttcagcctattgactagcgcttctttattcaaataggcccct cctttttttattaTATGGTACAATATGCTATCGgaacgcctgtgcttagtcaatgaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 1433679..1435412 /gene="adeC" /locus_tag="BSU_14520" /old_locus_tag="BSU14520" /EC_number="3.5.4.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:6408059, 8550522, 17183219" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6408059, 8550522, 17183219; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="adenine deaminase" /protein_id="NP_389335.2" /db_xref="EnsemblGenomes-Gn:BSU14520" /db_xref="EnsemblGenomes-Tr:CAB13325" /db_xref="GOA:P39761" /db_xref="InterPro:IPR006679" /db_xref="InterPro:IPR006680" /db_xref="InterPro:IPR011059" /db_xref="InterPro:IPR026912" /db_xref="InterPro:IPR032466" /db_xref="SubtiList:BG11044" /db_xref="UniProtKB/Swiss-Prot:P39761" /translation="MNKEALVNRLNASAKRQKADIVIKNGKIMDVYNQEWIYEDIAIT DGVIVGLGEYEGENIIDAEGQMIVPGFIDGHVHIESSMVTPIEFAKAVLPHGVTTVVT DPHEIANVSGEKGIEFMLEQARHTPLNIHFMLPSSVPAASFERSGAILKAADLKPFYE EEEVLGLAEVMDYVSVQQAEKDMVQKLLDARVAGKRIDGHLAGLSTDLINIYRTAFVL NDHEVTSKEEALDRIRRGMYVMMREGSVAKNTLNVLPAVNEKNARRFFFCTDDKHVDD LLSEGSVNHQVKMAIQAGLNPFLAYQLGSLNAAECYGLDTKGAIAPGFDADLLFVSDL ENVTVTMTMVKGQTVAEDSKAVYQDHASTAAPDQALLDSVKLAAPLNKQDFHMPIDSE QQINVIQIIPNQLETRLVQVPAPVAREFEPDTELDLLKIAVVERHKGLKETGLGVVKG FGFKSGAIATTISHDSHNIIAVGTNDEDIAAAVNKLQEIGGGLTIIKNGEELHSVPLP IAGLLSDQSAEQVNQSLLTLHDKLSLIGFTGGFNPFLTLSFLALPVIPDIKMTTTGLF DVKSFQHISLQ*" /label="adeC CDS" gene 1433679..1435412 /gene="adeC" /locus_tag="BSU_14520" /old_locus_tag="BSU14520" /label="adeC gene" S_feature complement(1434807..1435411) /Source="Nicolas_S_feature" /locus_tag="new_1522479_1523083_c" /HighExp="Etha, C30, C90, dia15, LBGexp, Cold, dia5, S8, G180, S7" /AntisenseName="adeC" /AntisenseCor="-9.8927927273806792E-3" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S528" downshifts 1435401 /Source="Nicolas_upshifts" /id="D812" /incds=0 /nref=51 /ntot=223 /MaxReadThrough="1.93923" /MaxDrop="6.63088" /score="44.3452043" /energy="-19.5" /TU="NA" /idTUdmin="U1197" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" CDS complement(1435446..1437113) /gene="rnjA" /locus_tag="BSU_14530" /old_locus_tag="BSU14530" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12682299, 15831787, 17005971, 17229210, 17512403, 18713320, 19850915, 21893285, 21893286, 20025672, 22720735, 23504012, 24187087" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15831787, 17005971, 17229210, 17512403, 18713320, 19850915, 21893285, 21893286, 20025672, 22720735, 23504012, 24187087; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease J1" /protein_id="NP_389336.1" /db_xref="EnsemblGenomes-Gn:BSU14530" /db_xref="EnsemblGenomes-Tr:CAB13326" /db_xref="GOA:Q45493" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR001587" /db_xref="InterPro:IPR004613" /db_xref="InterPro:IPR011108" /db_xref="InterPro:IPR030854" /db_xref="InterPro:IPR036866" /db_xref="PDB:3ZQ4" /db_xref="SubtiList:BG11813" /db_xref="UniProtKB/Swiss-Prot:Q45493" /translation="MKFVKNDQTAVFALGGLGEIGKNTYAVQFQDEIVLIDAGIKFPE DELLGIDYVIPDYTYLVKNEDKIKGLFITHGHEDHIGGIPYLLRQVNIPVYGGKLAIG LLRNKLEEHGLLRQTKLNIIGEDDIVKFRKTAVSFFRTTHSIPDSYGIVVKTPPGNIV HTGDFKFDFTPVGEPANLTKMAEIGKEGVLCLLSDSTNSENPEFTMSERRVGESIHDI FRKVDGRIIFATFASNIHRLQQVIEAAVQNGRKVAVFGRSMESAIEIGQTLGYINCPK NTFIEHNEINRMPANKVTILCTGSQGEPMAALSRIANGTHRQISINPGDTVVFSSSPI PGNTISVSRTINQLYRAGAEVIHGPLNDIHTSGHGGQEEQKLMLRLIKPKFFMPIHGE YRMQKMHVKLATDCGIPEENCFIMDNGEVLALKGDEASVAGKIPSGSVYIDGSGIGDI GNIVLRDRRILSEEGLVIVVVSIDMDDFKISAGPDLISRGFVYMRESGDLINDAQELI SNHLQKVMERKTTQWSEIKNEITDTLAPFLYEKTKRRPMILPIIMEV*" /label="rnjA CDS" gene complement(1435446..1437113) /gene="rnjA" /locus_tag="BSU_14530" /old_locus_tag="BSU14530" /label="rnjA gene" downshifts complement(1435456) /Source="Nicolas_upshifts" /id="D813" /incds=0 /nref=149 /ntot=269 /MaxReadThrough="4.3738" /MaxDrop="8.12983" /score="37.2074215" /energy="-19.5" /TU="U1199" /idTUdmin="U1200" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(1437119..1437328) /gene="rnpZA" /locus_tag="BSU_14540" /old_locus_tag="BSU14540" /function="9.2: DNA-dependent RNA polymerase" /experiment="publication(s) with functional evidences, PMID:18289874, 24187087" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18289874, 24187087; Product type f: factor" /codon_start=1 /transl_table=11 /product="omega 1 subunit of RNA polymerase" /protein_id="NP_389337.1" /db_xref="EnsemblGenomes-Gn:BSU14540" /db_xref="EnsemblGenomes-Tr:CAB13327" /db_xref="InterPro:IPR009907" /db_xref="SubtiList:BG13335" /db_xref="UniProtKB/Swiss-Prot:O31718" /translation="MIYKVFYQEKADEVPVREKTDSLYIEGVSERDVRTKLKEKKFNI EFITPVDGAFLEYEQQSENFKVLEL*" /label="rnpZA CDS" gene complement(1437119..1437328) /gene="rnpZA" /locus_tag="BSU_14540" /old_locus_tag="BSU14540" /label="rnpZA gene" promotor_-10 complement(1437365..1437384) /Source="Nicolas_upshift_promotors" /id="U1199" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.952047952047952" /psig="0.999000999001" /xcortree=2285 /SigmaFactorBS="acaagggatctttcactttttgagagatccttattttgctca aggCTTTccttatattccgttTTCGAATATAATAGAATGAGcgagtctaacatacggc a" /listShort="ykzG, rnjA, S528" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1437387) /Source="Nicolas_upshifts" /id="U1199" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.952047952047952" /psig="0.999000999001" /xcortree=2285 /SigmaFactorBS="acaagggatctttcactttttgagagatccttattttgctca aggCTTTccttatattccgttTTCGAATATAATAGAATGAGcgagtctaacatacggc a" /listShort="ykzG, rnjA, S528" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1437389..1437566) /Source="Nicolas_S_feature" /locus_tag="new_1525061_1525238_c" /HighExp="S5, S8, S7, S6, S4, ferm, nit, T5.0H, HiTm, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.97062099999999996" /TUshortSig="SigGF" /TUshortPSig="0.828" /TUlongSig="NA" /TUlongPSig="NA" /label="S529" promotor_-35 complement(1437399..1437402) /Source="Nicolas_upshift_promotors" /id="U1199" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.952047952047952" /psig="0.999000999001" /xcortree=2285 /SigmaFactorBS="acaagggatctttcactttttgagagatccttattttgctca aggCTTTccttatattccgttTTCGAATATAATAGAATGAGcgagtctaacatacggc a" /listShort="ykzG, rnjA, S528" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(1437567) /Source="Nicolas_upshifts" /id="U1200" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.828171828171828" /psig="0.828171828171828" /xcortree=816 /SigmaFactorBS="aatcatattaaattccattaataaccaCGAAAAGtcttcctc aatctCCGTATACTATTtgtataaaagaactctgggacaaatttttcattaaaggagg g" /listShort="S529, ykzG, rnjA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1437569..1437580) /Source="Nicolas_upshift_promotors" /id="U1200" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.828171828171828" /psig="0.828171828171828" /xcortree=816 /SigmaFactorBS="aatcatattaaattccattaataaccaCGAAAAGtcttcctc aatctCCGTATACTATTtgtataaaagaactctgggacaaatttttcattaaaggagg g" /listShort="S529, ykzG, rnjA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1437594..1437600) /Source="Nicolas_upshift_promotors" /id="U1200" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.828171828171828" /psig="0.828171828171828" /xcortree=816 /SigmaFactorBS="aatcatattaaattccattaataaccaCGAAAAGtcttcctc aatctCCGTATACTATTtgtataaaagaactctgggacaaatttttcattaaaggagg g" /listShort="S529, ykzG, rnjA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1437639..1437646 /Source="Nicolas_upshift_promotors" /id="U1201" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.717282717282717" /psig="0.999000999001" /xcortree=1936 /SigmaFactorBS="tttaatatgatttttgaacgaaaTTGTTTGCtgaatgacaat ctTTTTGTATGATGAGGGTGGGaattgcagaccaagacgataaaggggaagttgcgat g" /listShort="ykrA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1437660..1437679 /Source="Nicolas_upshift_promotors" /id="U1201" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.717282717282717" /psig="0.999000999001" /xcortree=1936 /SigmaFactorBS="tttaatatgatttttgaacgaaaTTGTTTGCtgaatgacaat ctTTTTGTATGATGAGGGTGGGaattgcagaccaagacgataaaggggaagttgcgat g" /listShort="ykrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1437676 /Source="Nicolas_upshifts" /id="U1201" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.717282717282717" /psig="0.999000999001" /xcortree=1936 /SigmaFactorBS="tttaatatgatttttgaacgaaaTTGTTTGCtgaatgacaat ctTTTTGTATGATGAGGGTGGGaattgcagaccaagacgataaaggggaagttgcgat g" /listShort="ykrA" /GFF_Attribute="listLong" /label="upshifts" CDS 1437714..1438487 /gene="ykrA" /locus_tag="BSU_14550" /old_locus_tag="BSU14550" /EC_number="3.1.3.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_389338.1" /db_xref="EnsemblGenomes-Gn:BSU14550" /db_xref="EnsemblGenomes-Tr:CAB13328" /db_xref="GOA:Q45494" /db_xref="InterPro:IPR000150" /db_xref="InterPro:IPR006379" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG11814" /db_xref="UniProtKB/Swiss-Prot:Q45494" /translation="MDSKLIFFDIDGTIYDHDKNIPESTRKTVAELQRQGHHVFIASG RSPFLVKPILEELGIHSFISYNGQFVVFENQVIYKNPLPENAIRRLLKQADEGKHPVV FMAEDTMKATVADHPHVLEGIGSLKTDYPETDDLFYEGKEIFQLLLFCQDEEEKAYAA FPEFDLVRWHELSTDVLPHGGSKAEGIKKVIERLPFDIGDTYAFGDGLNDLQMIEYVG TGVAMGNAVPELKEIADFVTKPVDEDGIAYAVKELGLLK*" /label="ykrA CDS" gene 1437714..1438487 /gene="ykrA" /locus_tag="BSU_14550" /old_locus_tag="BSU14550" /label="ykrA gene" downshifts 1438458 /Source="Nicolas_upshifts" /id="D814" /incds=0 /nref=184 /ntot=249 /MaxReadThrough="2.83896" /MaxDrop="6.20802" /score="28.5519453" /energy="-15.4" /TU="U1201" /idTUdmin="U1201" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(1438523..1439077) /gene="defB" /locus_tag="BSU_14560" /old_locus_tag="BSU14560" /EC_number="3.5.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11429456, 16207374, 23944997, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11429456, 16207374, 23944997, 26735940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-formyl-cysteine deformylase (promiscuous)" /protein_id="NP_389339.1" /db_xref="EnsemblGenomes-Gn:BSU14560" /db_xref="EnsemblGenomes-Tr:CAB13329" /db_xref="GOA:Q45495" /db_xref="InterPro:IPR023635" /db_xref="InterPro:IPR036821" /db_xref="SubtiList:BG11815" /db_xref="UniProtKB/Swiss-Prot:Q45495" /translation="MITMENIVRDGHPALRETAEPVELPPTDAEKQQLADMIEFVKNS QNPELAEKYKLRPGVGLAAPQINIKKRMIAVHAEDASGKLYSYALFNPKIVSHSVEKS YLTSGEGCLSVDEAIPGYVPRYARIRVKGTTLEGENIDIRLKGFPAIVFQHEIDHLNG VMFYDHIDKENPFKEPENAIAIER*" /label="defB CDS" gene complement(1438523..1439077) /gene="defB" /locus_tag="BSU_14560" /old_locus_tag="BSU14560" /label="defB gene" downshifts complement(1438534) /Source="Nicolas_upshifts" /id="D815" /incds=0 /nref=208 /ntot=265 /MaxReadThrough="1.87469" /MaxDrop="5.89844" /score="28.3817715" /energy="-15.4" /TU="NA" /idTUdmin="U1202" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1439099..1439118) /Source="Nicolas_upshift_promotors" /id="U1202" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.686313686313686" /psig="0.995004995004995" /xcortree=1852 /SigmaFactorBS="gaccagccatatacggctggtcattcgttTCGTTGCAccttt gtgaagaaaTCCGATATAATTTACATATTaagctttaggagtgaagtttcttgattac t" /listShort="defB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1439109) /Source="Nicolas_upshifts" /id="U1202" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.686313686313686" /psig="0.995004995004995" /xcortree=1852 /SigmaFactorBS="gaccagccatatacggctggtcattcgttTCGTTGCAccttt gtgaagaaaTCCGATATAATTTACATATTaagctttaggagtgaagtttcttgattac t" /listShort="defB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1439133..1439140) /Source="Nicolas_upshift_promotors" /id="U1202" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.686313686313686" /psig="0.995004995004995" /xcortree=1852 /SigmaFactorBS="gaccagccatatacggctggtcattcgttTCGTTGCAccttt gtgaagaaaTCCGATATAATTTACATATTaagctttaggagtgaagtttcttgattac t" /listShort="defB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1439162 /Source="Nicolas_upshifts" /id="D816" /incds=0 /nref=1 /ntot=11 /MaxReadThrough="0.95601" /MaxDrop="4.18336" /score="0.455865843" /energy="-17.1" /TU="NA" /idTUdmin="U1201" /TUdmin=682 /isTUend="FALSE" /label="downshifts" downshifts complement(1439186) /Source="Nicolas_upshifts" /id="D817" /incds=0 /nref=44 /ntot=63 /MaxReadThrough="2.11854" /MaxDrop="8.20445" /score="-8.94821426" /energy="-15.3" /TU="NA" /idTUdmin="U1204" /TUdmin="-14" /isTUend="TRUE" /label="downshifts" CDS complement(1439187..1439345) /gene="ykzV" /locus_tag="BSU_14569" /old_locus_tag="BSU14569" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20156992, 21670523; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative type I toxin (toxin I motif)" /protein_id="YP_003097725.1" /db_xref="EnsemblGenomes-Gn:BSU14569" /db_xref="EnsemblGenomes-Tr:CAX52616" /db_xref="GOA:C0H409" /db_xref="InterPro:IPR010070" /db_xref="UniProtKB/Swiss-Prot:C0H409" /translation="MYGYGYGGGCCSYGGYGYGGCGYGYGRTFALIVVLFILLIIVGA AYLGGGCC*" /label="ykzV CDS" gene complement(1439187..1439345) /gene="ykzV" /locus_tag="BSU_14569" /old_locus_tag="BSU14569" /label="ykzV gene" CDS complement(1439252..1439395) /locus_tag="BSU_14568" /old_locus_tag="BSU14568" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative antitoxin" /protein_id="YP_009513955.1" /db_xref="EnsemblGenomes-Gn:BSU14568" /db_xref="EnsemblGenomes-Tr:CCQ48596" /db_xref="UniProtKB/TrEMBL:L8E9Z2" /translation="MPTYKGSGVIKRGGYVICMDMVTAEAAAVMVVTDMVAADMATAA PLR*" /label="putative antitoxin CDS" gene complement(1439252..1439395) /locus_tag="BSU_14568" /old_locus_tag="BSU14568" /label="gene" promotor_-35 1439341..1439345 /Source="Nicolas_upshift_promotors" /id="U1203" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=704 /SigmaFactorBS="tccgccgtaaccatatccaTACATattacataaCCTCCTCTT TTAATTacgccagagcctttataagtaggcatagcgtctaatataacctatgtaaaaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(1439346..1439414) /Source="Nicolas_S_feature" /locus_tag="new_1527018_1527086_c" /HighExp="S8, S7, BT, S6, G/S, B36, Pyr, S5, B60, SMMPr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S530" promotor_-10 1439355..1439369 /Source="Nicolas_upshift_promotors" /id="U1203" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=704 /SigmaFactorBS="tccgccgtaaccatatccaTACATattacataaCCTCCTCTT TTAATTacgccagagcctttataagtaggcatagcgtctaatataacctatgtaaaaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1439382 /Source="Nicolas_upshifts" /id="U1203" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=704 /SigmaFactorBS="tccgccgtaaccatatccaTACATattacataaCCTCCTCTT TTAATTacgccagagcctttataagtaggcatagcgtctaatataacctatgtaaaaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1439398..1439417) /Source="Nicolas_upshift_promotors" /id="U1204" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1277 /SigmaFactorBS="aaatgcaatactgaaattaaatcaaaaaagtgaaaaatcagg acagatGACCATACAActtttttgttttTACATAGGTTATATTAGACGctatgcctac t" /listShort="S530, ykzV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1439427) /Source="Nicolas_upshifts" /id="U1204" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1277 /SigmaFactorBS="aaatgcaatactgaaattaaatcaaaaaagtgaaaaatcagg acagatGACCATACAActtttttgttttTACATAGGTTATATTAGACGctatgcctac t" /listShort="S530, ykzV" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1439430..1439439) /Source="Nicolas_upshift_promotors" /id="U1204" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1277 /SigmaFactorBS="aaatgcaatactgaaattaaatcaaaaaagtgaaaaatcagg acagatGACCATACAActtttttgttttTACATAGGTTATATTAGACGctatgcctac t" /listShort="S530, ykzV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1439501..1439508 /Source="Nicolas_upshift_promotors" /id="U1205" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.74025974025974" /psig=1 /xcortree=2147 /SigmaFactorBS="atttaatttcagtattgcatttatacagcacggctATTGCCA AatgtccccatggaTTCTATAGTAGAAATTGTCAagattgggggatttaacgtgaaag a" /listShort="ykyA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1439522..1439541 /Source="Nicolas_upshift_promotors" /id="U1205" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.74025974025974" /psig=1 /xcortree=2147 /SigmaFactorBS="atttaatttcagtattgcatttatacagcacggctATTGCCA AatgtccccatggaTTCTATAGTAGAAATTGTCAagattgggggatttaacgtgaaag a" /listShort="ykyA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1439526 /Source="Nicolas_upshifts" /id="U1205" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.74025974025974" /psig=1 /xcortree=2147 /SigmaFactorBS="atttaatttcagtattgcatttatacagcacggctATTGCCA AatgtccccatggaTTCTATAGTAGAAATTGTCAagattgggggatttaacgtgaaag a" /listShort="ykyA" /GFF_Attribute="listLong" /label="upshifts" CDS 1439559..1440230 /gene="ykyA" /locus_tag="BSU_14570" /old_locus_tag="BSU14570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16684363, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_389340.2" /db_xref="EnsemblGenomes-Gn:BSU14570" /db_xref="EnsemblGenomes-Tr:CAB13330" /db_xref="GOA:P21884" /db_xref="InterPro:IPR019454" /db_xref="InterPro:IPR036785" /db_xref="SubtiList:BG10206" /db_xref="UniProtKB/Swiss-Prot:P21884" /translation="MKDAIKRRPGIKIGAFCAMALILTGCMGQDPVDSLHHSLEKAAE SEKPFQEEQNTLKELEAKENQLYDSVMKLNMDDYKKIVALSNKALENVSKREEHLKLE NDSMKKSETEFEEAKTSAEHIKEKDIKEKADAAANHMEKRYTSYGTMYKEYKKALELN KKLYMQLKDKDLTRDDLDQQIDKVNASYEKILKYSGEFNEQTEKYNKAREDLYDAAGY RVKKS*" /label="ykyA CDS" gene 1439559..1440230 /gene="ykyA" /locus_tag="BSU_14570" /old_locus_tag="BSU14570" /label="ykyA gene" promotor_-35 1439898..1439907 /Source="Nicolas_upshift_promotors" /id="U1206" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.613386613386613" /psig="0.613386613386613" /xcortree=595 /SigmaFactorBS="gcatgaaaaaatcggaaacagaatttGAGGAAGCAAaaacgt cagcggAACATATTAAGGAAAAAGAcataaaagaaaaggccgatgccgcagcaaacca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1439920..1439938 /Source="Nicolas_upshift_promotors" /id="U1206" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.613386613386613" /psig="0.613386613386613" /xcortree=595 /SigmaFactorBS="gcatgaaaaaatcggaaacagaatttGAGGAAGCAAaaacgt cagcggAACATATTAAGGAAAAAGAcataaaagaaaaggccgatgccgcagcaaacca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1439932 /Source="Nicolas_upshifts" /id="U1206" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.613386613386613" /psig="0.613386613386613" /xcortree=595 /SigmaFactorBS="gcatgaaaaaatcggaaacagaatttGAGGAAGCAAaaacgt cagcggAACATATTAAGGAAAAAGAcataaaagaaaaggccgatgccgcagcaaacca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1440177 /Source="Nicolas_upshifts" /id="D818" /incds=0 /nref=96 /ntot=244 /MaxReadThrough="3.9299" /MaxDrop="6.03956" /score="20.6110953" /energy="-9.9" /TU="U1205" /idTUdmin="U1206" /TUdmin=3 /isTUend="TRUE" /label="downshifts" promotor_-35 1440405..1440410 /Source="Nicolas_upshift_promotors" /id="U1207" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.524475524475524" /psig=1 /xcortree=2692 /SigmaFactorBS="aagcgaatacatttattgaaaatcagcgatgaaaacgATTGA CggttcttctttatttgGTGTAAACTAATCCATGTTAagcggtgttgtattagttttt t" /listShort="S531, pdhA, pdhB, S532, pdhC, pdhD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1440427..1440446 /Source="Nicolas_upshift_promotors" /id="U1207" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.524475524475524" /psig=1 /xcortree=2692 /SigmaFactorBS="aagcgaatacatttattgaaaatcagcgatgaaaacgATTGA CggttcttctttatttgGTGTAAACTAATCCATGTTAagcggtgttgtattagttttt t" /listShort="S531, pdhA, pdhB, S532, pdhC, pdhD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1440428..1440653 /Source="Nicolas_S_feature" /locus_tag="new_1528100_1528325" /HighExp="nit, MG-0.1, Diami, MG-0.2, ferm, dia5, Lbexp, dia0, Paraq, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S531" upshifts 1440428 /Source="Nicolas_upshifts" /id="U1207" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.524475524475524" /psig=1 /xcortree=2692 /SigmaFactorBS="aagcgaatacatttattgaaaatcagcgatgaaaacgATTGA CggttcttctttatttgGTGTAAACTAATCCATGTTAagcggtgttgtattagttttt t" /listShort="S531, pdhA, pdhB, S532, pdhC, pdhD" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(1440432..1440451) /Source="Nicolas_upshift_promotors" /id="U1208" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.363636363636364" /psig="0.616383616383616" /xcortree=293 /SigmaFactorBS="tagttacactctgctttgaactgtattatttcgaagttgtaa aaaactaatacaacaCCGCTTAACATGGATTAGTTtacaccaaataaagaagaaccgt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1440448) /Source="Nicolas_upshifts" /id="U1208" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.363636363636364" /psig="0.616383616383616" /xcortree=293 /SigmaFactorBS="tagttacactctgctttgaactgtattatttcgaagttgtaa aaaactaatacaacaCCGCTTAACATGGATTAGTTtacaccaaataaagaagaaccgt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1440552..1440560) /Source="Nicolas_upshift_promotors" /id="U1209" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.891108891108891" /psig="0.891108891108891" /xcortree=349 /SigmaFactorBS="tagacgtgcattccttttatacatacaaacttagggTACCCT AAAgtatcagcagtaaGTCGTATTAtattttagccgatccccagtttgccaaaacctt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1440558) /Source="Nicolas_upshifts" /id="U1209" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.891108891108891" /psig="0.891108891108891" /xcortree=349 /SigmaFactorBS="tagacgtgcattccttttatacatacaaacttagggTACCCT AAAgtatcagcagtaaGTCGTATTAtattttagccgatccccagtttgccaaaacctt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1440574..1440582) /Source="Nicolas_upshift_promotors" /id="U1209" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.891108891108891" /psig="0.891108891108891" /xcortree=349 /SigmaFactorBS="tagacgtgcattccttttatacatacaaacttagggTACCCT AAAgtatcagcagtaaGTCGTATTAtattttagccgatccccagtttgccaaaacctt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1440654..1441769 /gene="pdhA" /locus_tag="BSU_14580" /old_locus_tag="BSU14580" /EC_number="1.2.4.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1729239, 1784816, 4984174, 6409095, 6815422, 9352926, 9588797, 11976308, 12469342" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1729239, 1784816, 4984174, 6409095, 6815422, 9352926, 9588797, 11976308, 12469342; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyruvate dehydrogenase (E1 alpha subunit)" /protein_id="NP_389341.1" /db_xref="EnsemblGenomes-Gn:BSU14580" /db_xref="EnsemblGenomes-Tr:CAB13331" /db_xref="GOA:P21881" /db_xref="InterPro:IPR001017" /db_xref="InterPro:IPR017596" /db_xref="InterPro:IPR029061" /db_xref="SubtiList:BG10207" /db_xref="UniProtKB/Swiss-Prot:P21881" /translation="MAAKTKKAIVDSKKQFDAIKKQFETFQILNEKGEVVNEAAMPDL TDDQLKELMRRMVFTRVLDQRSISLNRQGRLGFYAPTAGQEASQIATHFALEKEDFVL PGYRDVPQLIWHGLPLYQAFLFSRGHFRGNQMPDDVNALSPQIIIGAQYIQTAGVALG LKKRGKKAVAITYTGDGGASQGDFYEGINFAGAYKAPAIFVVQNNRYAISTPVEKQSA AETIAQKAVAAGIVGVQVDGMDPLAVYAATAEARERAINGEGPTLIETLTFRYGPHTM AGDDPTKYRTKEIENEWEQKDPLVRFRAFLENKGLWSEEEEAKVIEDAKEEIKQAIKK ADAEPKQKVTDLMKIMYEKMPHNLEEQFEIYTQKESK*" /label="pdhA CDS" gene 1440654..1441769 /gene="pdhA" /locus_tag="BSU_14580" /old_locus_tag="BSU14580" /label="pdhA gene" CDS 1441773..1442750 /gene="pdhB" /locus_tag="BSU_14590" /old_locus_tag="BSU14590" /EC_number="1.2.4.1" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1784816, 9352926, 9588797, 9891797, 10735853, 11976308" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1784816, 9352926, 9588797, 9891797, 10735853, 11976308; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="pyruvate dehydrogenase (E1 beta subunit)" /protein_id="NP_389342.1" /db_xref="EnsemblGenomes-Gn:BSU14590" /db_xref="EnsemblGenomes-Tr:CAB13332" /db_xref="GOA:P21882" /db_xref="InterPro:IPR005475" /db_xref="InterPro:IPR009014" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR033248" /db_xref="SubtiList:BG10208" /db_xref="UniProtKB/Swiss-Prot:P21882" /translation="MAQMTMIQAITDALRTELKNDENVLVFGEDVGVNGGVFRATEGL QKEFGEDRVFDTPLAESGIGGLALGLGLNGFRPVMEIQFFGFVYEVMDSVSGQMARMR YRSGGRWTSPVTIRSPFGGGVHTPELHADSLEGLVAQQPGIKVVIPSTPYDAKGLLIS AIRDNDPVVFLEHMKLYRSFRQEVPEEEYTIELGKADVKREGTDLSIITYGAMVHESL KAADELEKDGISAEVVDLRTVSPLDIDTIIASVEKTGRAIVVQEAQKQAGIAANVVAE INDRAILSLEAPVLRVAAPDTVFPFSQAESVWLPNHKDVLETARKVLEF*" /label="pdhB CDS" gene 1441773..1442750 /gene="pdhB" /locus_tag="BSU_14590" /old_locus_tag="BSU14590" /label="pdhB gene" S_feature 1442751..1442864 /Source="Nicolas_S_feature" /locus_tag="new_1530423_1530536" /HighExp="G150, LBGexp, MG-0.1, G180, C30, Diami, Oxctl, G135, ferm, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S532" promotor_-10 complement(1442785..1442804) /Source="Nicolas_upshift_promotors" /id="U1210" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.77022977022977" /psig="0.802197802197802" /xcortree=789 /SigmaFactorBS="ttctcgacctcctagtttgattaagcaattttaaagtttaCA TCgtaagcattgaaaaCAGATATATAATAGAGGGAAaacgttcatcttccctctcgat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1442802) /Source="Nicolas_upshifts" /id="U1210" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.77022977022977" /psig="0.802197802197802" /xcortree=789 /SigmaFactorBS="ttctcgacctcctagtttgattaagcaattttaaagtttaCA TCgtaagcattgaaaaCAGATATATAATAGAGGGAAaacgttcatcttccctctcgat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1442819..1442822) /Source="Nicolas_upshift_promotors" /id="U1210" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.77022977022977" /psig="0.802197802197802" /xcortree=789 /SigmaFactorBS="ttctcgacctcctagtttgattaagcaattttaaagtttaCA TCgtaagcattgaaaaCAGATATATAATAGAGGGAAaacgttcatcttccctctcgat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1442865..1444193 /gene="pdhC" /locus_tag="BSU_14600" /old_locus_tag="BSU14600" /EC_number="2.3.1.12" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1784816, 9352926, 9588797, 10735853, 11976308, 22720735, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1784816, 9352926, 9588797, 10735853, 11976308, 22720735, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyruvate dehydrogenase (dihydrolipoamide acetyltransferase E2 subunit)" /protein_id="NP_389343.1" /db_xref="EnsemblGenomes-Gn:BSU14600" /db_xref="EnsemblGenomes-Tr:CAB13333" /db_xref="GOA:P21883" /db_xref="InterPro:IPR000089" /db_xref="InterPro:IPR001078" /db_xref="InterPro:IPR003016" /db_xref="InterPro:IPR004167" /db_xref="InterPro:IPR011053" /db_xref="InterPro:IPR036625" /db_xref="SubtiList:BG10209" /db_xref="UniProtKB/Swiss-Prot:P21883" /translation="MAFEFKLPDIGEGIHEGEIVKWFVKPNDEVDEDDVLAEVQNDKA VVEIPSPVKGKVLELKVEEGTVATVGQTIITFDAPGYEDLQFKGSDESDDAKTEAQVQ STAEAGQDVAKEEQAQEPAKATGAGQQDQAEVDPNKRVIAMPSVRKYAREKGVDIRKV TGSGNNGRVVKEDIDSFVNGGAQEAAPQETAAPQETAAKPAAAPAPEGEFPETREKMS GIRKAIAKAMVNSKHTAPHVTLMDEVDVTNLVAHRKQFKQVAADQGIKLTYLPYVVKA LTSALKKFPVLNTSIDDKTDEVIQKHYFNIGIAADTEKGLLVPVVKNADRKSVFEISD EINGLATKAREGKLAPAEMKGASCTITNIGSAGGQWFTPVINHPEVAILGIGRIAEKA IVRDGEIVAAPVLALSLSFDHRMIDGATAQNALNHIKRLLNDPQLILMEA*" /label="pdhC CDS" gene 1442865..1444193 /gene="pdhC" /locus_tag="BSU_14600" /old_locus_tag="BSU14600" /label="pdhC gene" promotor_-35 1443009..1443016 /Source="Nicolas_upshift_promotors" /id="U1211" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.659340659340659" /psig="0.993006993006993" /xcortree=2451 /SigmaFactorBS="ctgaagtccaaaatgataaagcagtagtagaaattCCTTCAC CtgttaaaggaaaagTATTAGAATTAAAAGTTGAAgagggaacggttgcaactgttgg a" /listShort="pdhD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1443031..1443050 /Source="Nicolas_upshift_promotors" /id="U1211" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.659340659340659" /psig="0.993006993006993" /xcortree=2451 /SigmaFactorBS="ctgaagtccaaaatgataaagcagtagtagaaattCCTTCAC CtgttaaaggaaaagTATTAGAATTAAAAGTTGAAgagggaacggttgcaactgttgg a" /listShort="pdhD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1443034 /Source="Nicolas_upshifts" /id="U1211" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.659340659340659" /psig="0.993006993006993" /xcortree=2451 /SigmaFactorBS="ctgaagtccaaaatgataaagcagtagtagaaattCCTTCAC CtgttaaaggaaaagTATTAGAATTAAAAGTTGAAgagggaacggttgcaactgttgg a" /listShort="pdhD" /GFF_Attribute="listLong" /label="upshifts" CDS 1444198..1445610 /gene="pdhD" /locus_tag="BSU_14610" /old_locus_tag="BSU14610" /EC_number="1.8.1.4" /EC_number="1.2.1.25" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1784816, 6815422, 9352926, 9588797, 12682299, 21856851" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1784816, 6815422, 9352926, 9588797, 12682299, 21856851; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="dihydrolipoamide dehydrogenase E3 subunit of both pyruvate dehydrogenase and 2-oxoglutarate dehydrogenase complexes" /protein_id="NP_389344.1" /db_xref="EnsemblGenomes-Gn:BSU14610" /db_xref="EnsemblGenomes-Tr:CAB13334" /db_xref="GOA:P21880" /db_xref="InterPro:IPR001100" /db_xref="InterPro:IPR004099" /db_xref="InterPro:IPR006258" /db_xref="InterPro:IPR012999" /db_xref="InterPro:IPR016156" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG10210" /db_xref="UniProtKB/Swiss-Prot:P21880" /translation="MVVGDFPIETDTLVIGAGPGGYVAAIRAAQLGQKVTVVEKATLG GVCLNVGCIPSKALINAGHRYENAKHSDDMGITAENVTVDFTKVQEWKASVVNKLTGG VAGLLKGNKVDVVKGEAYFVDSNSVRVMDENSAQTYTFKNAIIATGSRPIELPNFKYS ERVLNSTGALALKEIPKKLVVIGGGYIGTELGTAYANFGTELVILEGGDEILPGFEKQ MSSLVTRRLKKKGNVEIHTNAMAKGVEERPDGVTVTFEVKGEEKTVDADYVLITVGRR PNTDELGLEQVGIEMTDRGIVKTDKQCRTNVPNIYAIGDIIEGPPLAHKASYEGKIAA EAIAGEPAEIDYLGIPAVVFSEPELASVGYTEAQAKEEGLDIVAAKFPFAANGRALSL NETDGFMKLITRKEDGLVIGAQIAGASASDMISELSLAIEGGMTAEDIAMTIHAHPTL GEITMEAAEVAIGSPIHIVK*" /label="pdhD CDS" gene 1444198..1445610 /gene="pdhD" /locus_tag="BSU_14610" /old_locus_tag="BSU14610" /label="pdhD gene" downshifts 1445607 /Source="Nicolas_upshifts" /id="D819" /incds=0 /nref=241 /ntot=268 /MaxReadThrough="1.82289" /MaxDrop="9.27853" /score="33.2247807" /energy="-12.1" /TU="NA" /idTUdmin="U1207" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1445655..1446029) /gene="slp" /locus_tag="BSU_14620" /old_locus_tag="BSU14620" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:1936936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1936936; Product type s : structure" /codon_start=1 /transl_table=11 /product="small peptidoglycan-associated lipoprotein" /protein_id="NP_389345.1" /db_xref="EnsemblGenomes-Gn:BSU14620" /db_xref="EnsemblGenomes-Tr:CAB13335" /db_xref="GOA:P39910" /db_xref="SubtiList:BG10211" /db_xref="UniProtKB/Swiss-Prot:P39910" /translation="MRYRAVFPMLIIVFALSGCTLSTINPMKKSRIDNIHHTQILFFS DENQIDQEAPYYDALLDLEKDYPEQIDKMKVYDKKEGWEDEIETVPTLMVVDQRHVVV KIEGCVKKKEDIIKPLQHVLSK*" /label="slp CDS" gene complement(1445655..1446029) /gene="slp" /locus_tag="BSU_14620" /old_locus_tag="BSU14620" /label="slp gene" downshifts complement(1445703) /Source="Nicolas_upshifts" /id="D820" /incds=0 /nref=26 /ntot=132 /MaxReadThrough="1.54024" /MaxDrop="3.69756" /score="4.23955997" /energy="-12.1" /TU="NA" /idTUdmin="U1212" /TUdmin=3 /isTUend="TRUE" /label="downshifts" misc_feature complement(1446060..1446079) /Source="Nicolas_upshift_promotors" /id="U1212" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=581 /SigmaFactorBS="ggtttcaattatataacaattaggtaacaagaagcagattaa gccgtctctCGTGATAAACTAAAGCTAGTtaactactgtttatacagaggagaagata g" /listShort="slp" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1446070) /Source="Nicolas_upshifts" /id="U1212" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=581 /SigmaFactorBS="ggtttcaattatataacaattaggtaacaagaagcagattaa gccgtctctCGTGATAAACTAAAGCTAGTtaactactgtttatacagaggagaagata g" /listShort="slp" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1446233..1446238 /Source="Nicolas_upshift_promotors" /id="U1213" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1078 /SigmaFactorBS="cattcttggatgaaagttcaagaaaacgtGCAATTacattat gtgctgtgGCATATATATCGAGTAAAGcttctgtatgaagaagatattgtatgatgga a" /listShort="S533, ykzW" /listLong="S534, yktA" /label="promotor_-35" promotor_-10 1446254..1446272 /Source="Nicolas_upshift_promotors" /id="U1213" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1078 /SigmaFactorBS="cattcttggatgaaagttcaagaaaacgtGCAATTacattat gtgctgtgGCATATATATCGAGTAAAGcttctgtatgaagaagatattgtatgatgga a" /listShort="S533, ykzW" /listLong="S534, yktA" /label="promotor_-10" upshifts 1446264 /Source="Nicolas_upshifts" /id="U1213" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1078 /SigmaFactorBS="cattcttggatgaaagttcaagaaaacgtGCAATTacattat gtgctgtgGCATATATATCGAGTAAAGcttctgtatgaagaagatattgtatgatgga a" /listShort="S533, ykzW" /listLong="S534, yktA" /label="upshifts" S_feature 1446268..1446377 /Source="Nicolas_S_feature" /locus_tag="new_1533940_1534049" /HighExp="S4, S5, S7, S6, S8, S3, BT, G/S, LoTm, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S533" downshifts complement(1446300) /Source="Nicolas_upshifts" /id="D821" /incds=0 /nref=4 /ntot=18 /MaxReadThrough="1.96608" /MaxDrop="3.4036" /score="51.898567" /energy="-16.8" /TU="NA" /idTUdmin="U1215" /TUdmin=308 /isTUend="FALSE" /label="downshifts" promotor_-35 1446361..1446368 /Source="Nicolas_upshift_promotors" /id="U1214" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=346 /SigmaFactorBS="gtgaatatgatgatatgaaataaaatgtgttatacagtttgt TGTTGACAttttaaatgtgacaTATTAATATAATAACAACAAaagaaattaagcgttt t" /listShort="ykzW, S534, yktA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1446379 /Source="Nicolas_upshifts" /id="U1214" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=346 /SigmaFactorBS="gtgaatatgatgatatgaaataaaatgtgttatacagtttgt TGTTGACAttttaaatgtgacaTATTAATATAATAACAACAAaagaaattaagcgttt t" /listShort="ykzW, S534, yktA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1446383..1446402 /Source="Nicolas_upshift_promotors" /id="U1214" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=346 /SigmaFactorBS="gtgaatatgatgatatgaaataaaatgtgttatacagtttgt TGTTGACAttttaaatgtgacaTATTAATATAATAACAACAAaagaaattaagcgttt t" /listShort="ykzW, S534, yktA" /GFF_Attribute="listLong" /label="promotor_-10" misc_RNA 1446398..1446608 /gene="srrA" /locus_tag="BSU_misc_RNA_70" /product="small regulatory RNA and messenger RNA (argininemetabolism)" /experiment="publication(s) with functional evidences, PMID:16164558, 17011578, 17020585, 17576690, 18511073, 18586936, 19726675, 20444087, 27449348" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16164558, 17011578, 17020585, 17576690, 18511073, 18586936, 19726675, 20444087, 27449348; Product type n: RNA" /function="16.3: Control" /label="srrA RNA" gene 1446398..1446608 /gene="srrA" /locus_tag="BSU_misc_RNA_70" /label="srrA gene" CDS 1446448..1446567 /gene="rgpA" /locus_tag="BSU_14629" /old_locus_tag="BSU14629" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16164558, 20444087, 27449348" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16164558, 20444087, 27449348; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of GapA synthesis" /protein_id="YP_003097726.1" /db_xref="EnsemblGenomes-Gn:BSU14629" /db_xref="EnsemblGenomes-Tr:CAX52617" /db_xref="InterPro:IPR025236" /db_xref="UniProtKB/Swiss-Prot:C0H410" /translation="MGTIVCQDCNEAIHYFEDEKVTTLYGTCCGQCQCPVDEE*" /label="rgpA CDS" gene 1446448..1446567 /gene="rgpA" /locus_tag="BSU_14629" /old_locus_tag="BSU14629" /label="rgpA gene" downshifts complement(1446454) /Source="Nicolas_upshifts" /id="D822" /incds=0 /nref=6 /ntot=35 /MaxReadThrough="3.43398" /MaxDrop="4.36472" /score="51.898567" /energy="-16.8" /TU="NA" /idTUdmin="U1215" /TUdmin=154 /isTUend="FALSE" /label="downshifts" downshifts 1446554 /Source="Nicolas_upshifts" /id="D823" /incds=0 /nref=59 /ntot=171 /MaxReadThrough="5.69396" /MaxDrop="7.24152" /score="51.2534618" /energy="-16.8" /TU="U1214" /idTUdmin="U1213" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 1446599..1448202 /Source="Nicolas_S_feature" /locus_tag="new_1534271_1535874" /HighExp="M9-stat, M0t90, B60, M40t90, T1.30H, T2.0H, T2.30H, T3.30H, T3.0H, T0.30H" /AntisenseName="speA" /AntisenseCor="-0.33575411980382203" /AntisenseRegPval="-7.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigEF" /TUlongPSig="0.998" /label="S534" CDS complement(1446607..1448079) /gene="speA" /locus_tag="BSU_14630" /old_locus_tag="BSU14630" /EC_number="4.1.1.19" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9723923, 19114526, 19255484, 20876533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9723923, 19114526, 19255484, 20876533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="arginine decarboxylase" /protein_id="NP_389346.1" /db_xref="EnsemblGenomes-Gn:BSU14630" /db_xref="EnsemblGenomes-Tr:CAB13336" /db_xref="GOA:P21885" /db_xref="InterPro:IPR000310" /db_xref="InterPro:IPR008286" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR036633" /db_xref="SubtiList:BG10212" /db_xref="UniProtKB/Swiss-Prot:P21885" /translation="MSQHETPLYTGLKKHASRQPVQFHIPGHKKGAGMDPEFRQFIGE NALSIDLINIEPLDDLHAPKGIIKQAQDLAAEAFGADHTFFSVQGTSGAIMTMVMAVC GPGDKIIIPRNVHKSIMTAIVFSGAVPIFIHPEIDNELGISHGITLESAKRALTEHPD AKGLLVINPTYFGVAADLKSIVELAHSFDVPVLVDEAHGVHIHFHDELPLSAMQAGAD IAATSVHKLGGSLTQSSILNMREGLVSKDRVQSILSMLTTTSTSYLLLASLDVARKRL ATEGRQLAEETLKLANQTRDRLNQIEGIYCVGSEILGSKAAYSYDPTKLIISVKSLGL TGHDVEKWLRESFNIEVELSDLYNILCIFTPGDSQNDADRLVEALTEIAQQMSEQDVT HQQTEVLLPEIPLLAMTPRDAFYANTEVIPLKEASGRIIAEFVMVYPPGIPIFIPGEI ITEENISYIFKNLDAGLPVQGPEDSTLHMIRVIKEQKAIQ*" /label="speA CDS" gene complement(1446607..1448079) /gene="speA" /locus_tag="BSU_14630" /old_locus_tag="BSU14630" /label="speA gene" downshifts complement(1446625) /Source="Nicolas_upshifts" /id="D824" /incds=0 /nref=62 /ntot=198 /MaxReadThrough="3.88498" /MaxDrop="6.76978" /score="51.898567" /energy="-16.8" /TU="NA" /idTUdmin="U1215" /TUdmin="-17" /isTUend="TRUE" /label="downshifts" S_feature complement(1448080..1448175) /Source="Nicolas_S_feature" /locus_tag="new_1535752_1535847_c" /HighExp="Paraq, G180, LBGexp, Oxctl, G150, G135, C30, H2O2, BMM, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S535" promotor_-10 complement(1448158..1448177) /Source="Nicolas_upshift_promotors" /id="U1215" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=2477 /SigmaFactorBS="cttaagagaaagcatcttcatttgatcataaattgtTCTTTA CAttctttcaagttcaTAATATAATTCATTTGTTTTacgtctaaaaaacggttgagaa a" /listShort="S535, speA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1448175) /Source="Nicolas_upshifts" /id="U1215" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=2477 /SigmaFactorBS="cttaagagaaagcatcttcatttgatcataaattgtTCTTTA CAttctttcaagttcaTAATATAATTCATTTGTTTTacgtctaaaaaacggttgagaa a" /listShort="S535, speA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1448182..1448185 /Source="Nicolas_upshift_promotors" /id="U1216" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.675324675324675" /psig=1 /xcortree=2377 /SigmaFactorBS="cgttttttagacgtaaaacaaatgaattatattatgaaCTTG aaagaatgtaaagaACAATTTATGATCAAATGAAgatgctttctcttaagggaagtaa a" /listShort="yktA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(1448192..1448199) /Source="Nicolas_upshift_promotors" /id="U1215" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=2477 /SigmaFactorBS="cttaagagaaagcatcttcatttgatcataaattgtTCTTTA CAttctttcaagttcaTAATATAATTCATTTGTTTTacgtctaaaaaacggttgagaa a" /listShort="S535, speA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1448200..1448219 /Source="Nicolas_upshift_promotors" /id="U1216" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.675324675324675" /psig=1 /xcortree=2377 /SigmaFactorBS="cgttttttagacgtaaaacaaatgaattatattatgaaCTTG aaagaatgtaaagaACAATTTATGATCAAATGAAgatgctttctcttaagggaagtaa a" /listShort="yktA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1448204 /Source="Nicolas_upshifts" /id="U1216" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.675324675324675" /psig=1 /xcortree=2377 /SigmaFactorBS="cgttttttagacgtaaaacaaatgaattatattatgaaCTTG aaagaatgtaaagaACAATTTATGATCAAATGAAgatgctttctcttaagggaagtaa a" /listShort="yktA" /GFF_Attribute="listLong" /label="upshifts" CDS 1448264..1448530 /gene="yktA" /locus_tag="BSU_14640" /old_locus_tag="BSU14640" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 19429628, 22333191" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389347.1" /db_xref="EnsemblGenomes-Gn:BSU14640" /db_xref="EnsemblGenomes-Tr:CAB13337" /db_xref="InterPro:IPR007920" /db_xref="InterPro:IPR023324" /db_xref="SubtiList:BG11816" /db_xref="UniProtKB/Swiss-Prot:Q45497" /translation="MEYQYPMNEDWTTEEAVDVIAFFQQVELAYEKGADREELLKAYR RFKEIVPGKAEEKKLCGEFEEQSTYSPYRTVKQARESDHAKIKM*" /label="yktA CDS" gene 1448264..1448530 /gene="yktA" /locus_tag="BSU_14640" /old_locus_tag="BSU14640" /label="yktA gene" downshifts 1448512 /Source="Nicolas_upshifts" /id="D825" /incds=0 /nref=105 /ntot=250 /MaxReadThrough="2.62284" /MaxDrop="5.09814" /score="40.0811023" /energy="-16.1" /TU="NA" /idTUdmin="U1214" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1448563..1449201) /gene="yktB" /locus_tag="BSU_14650" /old_locus_tag="BSU14650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 25643072" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389348.1" /db_xref="EnsemblGenomes-Gn:BSU14650" /db_xref="EnsemblGenomes-Tr:CAB13338" /db_xref="InterPro:IPR009403" /db_xref="PDB:2A8E" /db_xref="SubtiList:BG11817" /db_xref="UniProtKB/Swiss-Prot:Q45498" /translation="MTQMRFTEEDFNTFTIEGLDARMEVLKETVRPKLTALGEHFAPT LSALTGDEMFPHVAKHARRSVNPPADSWVAFANSKRGYKKLPHFQIGLWESHVFVWFA IIYESPIKEEYGKLLEVNQETITKNIPDSFVWSADHTKPGVHKQSEMDKEQLKTLFER LQTVKKAELLCGIQLQKEEVLNMNNQEFLQRIDDAFKQLAFLYRLTQKVTQA*" /label="yktB CDS" gene complement(1448563..1449201) /gene="yktB" /locus_tag="BSU_14650" /old_locus_tag="BSU14650" /label="yktB gene" downshifts complement(1448588) /Source="Nicolas_upshifts" /id="D826" /incds=0 /nref=184 /ntot=257 /MaxReadThrough="2.62959" /MaxDrop="6.54203" /score="26.7765804" /energy="-14.5" /TU="U1217" /idTUdmin="U1217" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1449222..1449241) /Source="Nicolas_upshift_promotors" /id="U1217" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.519480519480519" /psig="0.997002997002997" /xcortree=2002 /SigmaFactorBS="actcgtttattaccacatttctccttacttcaaacgcgctca atctTTTTGaagctcgtatgaacTGTGATAAAATATGTATACTtagcatgaaggagga a" /listShort="yktB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1449246) /Source="Nicolas_upshifts" /id="U1217" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.519480519480519" /psig="0.997002997002997" /xcortree=2002 /SigmaFactorBS="actcgtttattaccacatttctccttacttcaaacgcgctca atctTTTTGaagctcgtatgaacTGTGATAAAATATGTATACTtagcatgaaggagga a" /listShort="yktB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1449256..1449260) /Source="Nicolas_upshift_promotors" /id="U1217" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.519480519480519" /psig="0.997002997002997" /xcortree=2002 /SigmaFactorBS="actcgtttattaccacatttctccttacttcaaacgcgctca atctTTTTGaagctcgtatgaacTGTGATAAAATATGTATACTtagcatgaaggagga a" /listShort="yktB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1449271..1449277 /Source="Nicolas_upshift_promotors" /id="U1218" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=209 /SigmaFactorBS="tttatcacagttcatacgagcttcaaaaagattgagcgCGTT TGAagtaaggagaaatgTGGTAATAAACGAGTAGGTaaacacacaattttcagaatca t" /listShort="S536, ykzI, suhB, ykzC, S537" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1449292..1449310 /Source="Nicolas_upshift_promotors" /id="U1218" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=209 /SigmaFactorBS="tttatcacagttcatacgagcttcaaaaagattgagcgCGTT TGAagtaaggagaaatgTGGTAATAAACGAGTAGGTaaacacacaattttcagaatca t" /listShort="S536, ykzI, suhB, ykzC, S537" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1449293 /Source="Nicolas_upshifts" /id="U1218" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=209 /SigmaFactorBS="tttatcacagttcatacgagcttcaaaaagattgagcgCGTT TGAagtaaggagaaatgTGGTAATAAACGAGTAGGTaaacacacaattttcagaatca t" /listShort="S536, ykzI, suhB, ykzC, S537" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1449331..1449340 /Source="Nicolas_upshift_promotors" /id="U1219" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1258 /SigmaFactorBS="ataaacgagtaggtaaacacacaattttcagaatCATGTTGC GCgtaaatagaacaATCATACGATATAAGAAGTAatcattgttgaatggcaaaatggg a" /listShort="S536, ykzI, suhB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1449353..1449372 /Source="Nicolas_upshift_promotors" /id="U1219" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1258 /SigmaFactorBS="ataaacgagtaggtaaacacacaattttcagaatCATGTTGC GCgtaaatagaacaATCATACGATATAAGAAGTAatcattgttgaatggcaaaatggg a" /listShort="S536, ykzI, suhB" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1449357..1449440 /Source="Nicolas_S_feature" /locus_tag="new_1537029_1537112" /HighExp="Etha, S7, M9-stat, S6, S8, BT, Gly, Salt, B60, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigB" /TUshortPSig="0.987, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S536" upshifts 1449357 /Source="Nicolas_upshifts" /id="U1219" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1258 /SigmaFactorBS="ataaacgagtaggtaaacacacaattttcagaatCATGTTGC GCgtaaatagaacaATCATACGATATAAGAAGTAatcattgttgaatggcaaaatggg a" /listShort="S536, ykzI, suhB" /GFF_Attribute="listLong" /label="upshifts" CDS 1449441..1449629 /gene="ykzI" /locus_tag="BSU_14660" /old_locus_tag="BSU14660" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved general stress protein" /protein_id="NP_389349.1" /db_xref="EnsemblGenomes-Gn:BSU14660" /db_xref="EnsemblGenomes-Tr:CAB13339" /db_xref="SubtiList:BG13337" /db_xref="UniProtKB/Swiss-Prot:O31719" /translation="MRQVVKEGFKEEKNNRVAVWRLEVDYELATLYEAMQKENEEQIE QSKNKLERLRKEWIRLNG*" /label="ykzI CDS" gene 1449441..1449629 /gene="ykzI" /locus_tag="BSU_14660" /old_locus_tag="BSU14660" /label="ykzI gene" downshifts complement(1449446) /Source="Nicolas_upshifts" /id="D827" /incds=0 /nref=1 /ntot=15 /MaxReadThrough="1.50398" /MaxDrop="3.97385" /score="26.7765804" /energy="-14.5" /TU="NA" /idTUdmin="U1220" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 1449622 /Source="Nicolas_upshifts" /id="D828" /incds=0 /nref=13 /ntot=45 /MaxReadThrough="7.33866" /MaxDrop="6.12123" /score="-8.73613673" /energy="-8.1" /TU="U1218,U1219" /idTUdmin="U1219" /TUdmin="-628" /isTUend="FALSE" /label="downshifts" upshifts complement(1449644) /Source="Nicolas_upshifts" /id="U1220" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.616383616383616" /psig="0.105894105894106" /xcortree=118 /SigmaFactorBS="agcaaggaaaatgaaaaatatcccttctcacgtaaaaacgaa ccattcaTGCGgttcgttttcactatcgcttttttacccgttaagacgaatccattct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(1449652..1449655) /Source="Nicolas_upshift_promotors" /id="U1220" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.616383616383616" /psig="0.105894105894106" /xcortree=118 /SigmaFactorBS="agcaaggaaaatgaaaaatatcccttctcacgtaaaaacgaa ccattcaTGCGgttcgttttcactatcgcttttttacccgttaagacgaatccattct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-35 1449699..1449702 /Source="Nicolas_upshift_promotors" /id="U1221" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.519480519480519" /psig=1 /xcortree=1962 /SigmaFactorBS="gttcgtttttacgtgagaagggatatttttcattttcCTTGc tttttcattgccgttATCAGTATCCTATAAAATAAaaggtctacatagaagagaggta c" /listShort="suhB, ykzC, S537" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1449719..1449738 /Source="Nicolas_upshift_promotors" /id="U1221" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.519480519480519" /psig=1 /xcortree=1962 /SigmaFactorBS="gttcgtttttacgtgagaagggatatttttcattttcCTTGc tttttcattgccgttATCAGTATCCTATAAAATAAaaggtctacatagaagagaggta c" /listShort="suhB, ykzC, S537" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1449722 /Source="Nicolas_upshifts" /id="U1221" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.519480519480519" /psig=1 /xcortree=1962 /SigmaFactorBS="gttcgtttttacgtgagaagggatatttttcattttcCTTGc tttttcattgccgttATCAGTATCCTATAAAATAAaaggtctacatagaagagaggta c" /listShort="suhB, ykzC, S537" /GFF_Attribute="listLong" /label="upshifts" CDS 1449769..1450566 /gene="suhB" /locus_tag="BSU_14670" /old_locus_tag="BSU14670" /EC_number="3.1.3.-" /EC_number="3.1.3.25" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11914086, 16682444, 22333191, 27784292" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11914086, 16682444, 22333191, 27784292; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="inositol monophosphatase / 5' nucleotidase (purine nucleoside monophosphate)" /protein_id="NP_389350.1" /db_xref="EnsemblGenomes-Gn:BSU14670" /db_xref="EnsemblGenomes-Tr:CAB13340" /db_xref="GOA:Q45499" /db_xref="InterPro:IPR000760" /db_xref="InterPro:IPR020550" /db_xref="InterPro:IPR020583" /db_xref="InterPro:IPR033942" /db_xref="SubtiList:BG11818" /db_xref="UniProtKB/Swiss-Prot:Q45499" /translation="MTNWTEIDEIAKKWIREAGARITQSMHESLTIETKSNPNDLVTN IDKETEKFFIDRIQETFPGHRILGEEGQGDKIHSLEGVVWIIDPIDGTMNFVHQQRNF AISIGIFENGEGKIGLIYDVVHDELYHAFSGRGAYMNETKLAPLKETVIEEAILAINA TWVTENRRIDQSVLAPLVKRVRGTRSYGSAALELANVAAGRIDAYITMRLAPWDYAAG CVLLNEVGGTYTTIEGEPFTFLENHSVLAGNPSIHKTIFEEYLHARK*" /label="suhB CDS" gene 1449769..1450566 /gene="suhB" /locus_tag="BSU_14670" /old_locus_tag="BSU14670" /label="suhB gene" CDS 1450592..1451020 /gene="ykzC" /locus_tag="BSU_14680" /old_locus_tag="BSU14680" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11544224; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyltransferase" /protein_id="NP_389351.1" /db_xref="EnsemblGenomes-Gn:BSU14680" /db_xref="EnsemblGenomes-Tr:CAB13341" /db_xref="GOA:O31720" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13331" /db_xref="UniProtKB/Swiss-Prot:O31720" /translation="MLEKLAEAHPVWKEEEFGDKDAEDYIISYSMYNGSWLVWEKDGM PVAVSYHLEWSPSNGKPWLGTVLIDPAEEKKGHAKMIIEQISKLLRAKHKAMFAGVPI ERREWILFLSQCGFEQLKTEKDEKGKSFMILVKPLAEAAV*" /label="ykzC CDS" gene 1450592..1451020 /gene="ykzC" /locus_tag="BSU_14680" /old_locus_tag="BSU14680" /label="ykzC gene" downshifts 1450977 /Source="Nicolas_upshifts" /id="D829" /incds=0 /nref=80 /ntot=232 /MaxReadThrough="4.50069" /MaxDrop="4.3098" /score="-9.99315734" /energy="-11.8" /TU="U1218,U1221" /idTUdmin="U1218" /TUdmin="-153" /isTUend="FALSE" /label="downshifts" S_feature 1451021..1451974 /Source="Nicolas_S_feature" /locus_tag="new_1538693_1539646" /HighExp="H2O2, dia15, Diami, Paraq, G180, G135, G150, dia5, Heat, LBGexp" /AntisenseName="yktD" /AntisenseCor="-1.5120906229522399E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="0.117724" /TUshortSig="SigA, SigB" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S537" downshifts complement(1451096) /Source="Nicolas_upshifts" /id="D830" /incds=0 /nref=4 /ntot=85 /MaxReadThrough="0.88821" /MaxDrop="3.44773" /score="19.9363134" /energy="-12.8" /TU="NA" /idTUdmin="U1222" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1451098..1452012) /gene="yktD" /locus_tag="BSU_14690" /old_locus_tag="BSU14690" /EC_number="2.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17928718; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative AdoMet-dependent methyltransferase" /protein_id="NP_389352.1" /db_xref="EnsemblGenomes-Gn:BSU14690" /db_xref="EnsemblGenomes-Tr:CAB13342" /db_xref="GOA:Q45500" /db_xref="InterPro:IPR007213" /db_xref="InterPro:IPR011610" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11819" /db_xref="UniProtKB/Swiss-Prot:Q45500" /translation="MRKNESSLTSLISAFARAYHSRYDTPLIFDDFIAKDLINEKEFI DISKNMIQEISFFNKEIAERLQNDPEKILKWVAQIQLSPTPLARASYCEKVLHNELIL GAKQYVILGAGLDTFCFRHPELENSLQVFEVDHPATQQLKKNKLKDANLTIPGHLHFV PMDFTKTFSYDPLLDEGFKNTKTFFSLLGVSYYVTREENASLISNLFSHVPPGSSIVF DYADETLFTAKGTSNRVEHMVKMAAASGEPMKSCFTYQEIEHLLESSGLLIYEHLSPD DINDLFFSNRKDNLSAFETIHYIHAVKK*" /label="yktD CDS" gene complement(1451098..1452012) /gene="yktD" /locus_tag="BSU_14690" /old_locus_tag="BSU14690" /label="yktD gene" promotor_-10 complement(1452078..1452097) /Source="Nicolas_upshift_promotors" /id="U1222" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=584 /SigmaFactorBS="gatcgcgcgtccagttaagagcaaaaaCATTGACAaaaaaat ttatttaTGCTAAAATTTACTATTAATatatttgtatgtataataagattctcctggc c" /listShort="yktD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1452086) /Source="Nicolas_upshifts" /id="U1222" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=584 /SigmaFactorBS="gatcgcgcgtccagttaagagcaaaaaCATTGACAaaaaaat ttatttaTGCTAAAATTTACTATTAATatatttgtatgtataataagattctcctggc c" /listShort="yktD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1452112..1452119) /Source="Nicolas_upshift_promotors" /id="U1222" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=584 /SigmaFactorBS="gatcgcgcgtccagttaagagcaaaaaCATTGACAaaaaaat ttatttaTGCTAAAATTTACTATTAATatatttgtatgtataataagattctcctggc c" /listShort="yktD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1452364..1453929) /gene="nprE" /locus_tag="BSU_14700" /old_locus_tag="BSU14700" /EC_number="3.4.24.28" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:2128597, 6090407, 8436952, 15205417, 26728191" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2128597, 6090407, 8436952, 15205417, 26728191; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="extracellular neutral metalloprotease" /protein_id="NP_389353.1" /db_xref="EnsemblGenomes-Gn:BSU14700" /db_xref="EnsemblGenomes-Tr:CAB13343" /db_xref="GOA:P68736" /db_xref="InterPro:IPR001570" /db_xref="InterPro:IPR011096" /db_xref="InterPro:IPR013856" /db_xref="InterPro:IPR023612" /db_xref="InterPro:IPR025711" /db_xref="SubtiList:BG10448" /db_xref="UniProtKB/Swiss-Prot:P68736" /translation="MGLGKKLSVAVAASFMSLSISLPGVQAAEGHQLKENQTNFLSKN AIAQSELSAPNDKAVKQFLKKNSNIFKGDPSKRLKLVESTTDALGYKHFRYAPVVNGV PIKDSQVIVHVDKSDNVYAVNGELHNQSAAKTDNSQKVSSEKALALAFKAIGKSPDAV SNGAAKNSNKAELKAIETKDGSYRLAYDVTIRYVEPEPANWEVLVDAETGSILKQQNK VEHAAATGSGTTLKGATVPLNISYEGGKYVLRDLSKPTGTQIITYDLQNRQSRLPGTL VSSTTKTFTSSSQRAAVDAHYNLGKVYDYFYSNFKRNSYDNKGSKIVSSVHYGTQYNN AAWTGDQMIYGDGDGSFFSPLSGSLDVTAHEMTHGVTQETANLIYENQPGALNESFSD VFGYFNDTEDWDIGEDITVSQPALRSLSNPTKYNQPDNYANYRNLPNTDEGDYGGVHT NSGIPNKAAYNTITKLGVSKSQQIYYRALTTYLTPSSTFKDAKAALIQSARDLYGSTD AAKVEAAWNAVGL*" /label="nprE CDS" gene complement(1452364..1453929) /gene="nprE" /locus_tag="BSU_14700" /old_locus_tag="BSU14700" /label="nprE gene" promotor_-10 complement(1453964..1453983) /Source="Nicolas_upshift_promotors" /id="U1223" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.526473526473527" /psig="0.993006993006993" /xcortree=3157 /SigmaFactorBS="tactatcaattttgtctagttatgttagtttTTGTTGAGtat tccagaatgcTAGTTTAATATAACAATATAaagttttcagtattttcaaaaaggggga t" /listShort="nprE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1453975) /Source="Nicolas_upshifts" /id="U1223" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.526473526473527" /psig="0.993006993006993" /xcortree=3157 /SigmaFactorBS="tactatcaattttgtctagttatgttagtttTTGTTGAGtat tccagaatgcTAGTTTAATATAACAATATAaagttttcagtattttcaaaaaggggga t" /listShort="nprE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1453997..1454004) /Source="Nicolas_upshift_promotors" /id="U1223" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.526473526473527" /psig="0.993006993006993" /xcortree=3157 /SigmaFactorBS="tactatcaattttgtctagttatgttagtttTTGTTGAGtat tccagaatgcTAGTTTAATATAACAATATAaagttttcagtattttcaaaaaggggga t" /listShort="nprE" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1454214..1456154 /gene="ylaA" /locus_tag="BSU_14710" /old_locus_tag="BSU14710" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16501307" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389354.1" /db_xref="EnsemblGenomes-Gn:BSU14710" /db_xref="EnsemblGenomes-Tr:CAB13344" /db_xref="GOA:O07625" /db_xref="SubtiList:BG13338" /db_xref="UniProtKB/Swiss-Prot:O07625" /translation="MLFVLELFSHYVLHFERYFILSRQSTLLIQWSIVVLAGLYLLVH HPKINRQRTMFLAGVILRIVLLAGVSVELIHQVQSTNFTSAYLREDGKELLPLLHFLL YGYVLLTAFHYMLMPRDHGGKGKFYTFDLAVVSLPIVQMIFSFFSYWKEYPDGMEPIA FVFLFFIITLPIALNVVFFKLYWRTDKILLGLFYTLIIGLLVLLLAPYPNQISKDYGA VMPYTIYLAMAGFLMSYHLFQKSGKVYVRVNKWVTMAVMVFFVLLLNPIYNIGTAAFA VSKPANVHDSFNFVGEHISSEKAEQILKSFFPTDETLYLHDTNMDVHYFYSFESKGYK AEVDEVSQLIRNYEYLQKAHGKKLTNQEYKRKSIAFLERHGRVLHKDHIETKVSQEDG QTVVRIYLKNQLHKKDHADDGAVFYWEKETLMGFSEDPSIYQLDSLLHVHITEQDIHD KVEQMFTALNISKQPYQITDIESDSLLGSMVRVETKVGIVLEFEGESGCLHSLSLPMK KNISMANSRLQHQILSIFDARGSEKKKKSSQGDMVMYTDSSKTYEFVEAQGQLNVYVY SDTPDQSFPYTYRNGTLAYEKVASLYQDVIYKKRMRPIIVQRGDERHYAWLIIIQPFG SNRHDAYVVDGETQEVKSLYES*" /label="ylaA CDS" gene 1454214..1456154 /gene="ylaA" /locus_tag="BSU_14710" /old_locus_tag="BSU14710" /label="ylaA gene" CDS 1456144..1456413 /gene="ylaB" /locus_tag="BSU_14720" /old_locus_tag="BSU14720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 16501307" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_389355.1" /db_xref="EnsemblGenomes-Gn:BSU14720" /db_xref="EnsemblGenomes-Tr:CAB13345" /db_xref="GOA:O07626" /db_xref="SubtiList:BG13339" /db_xref="UniProtKB/Swiss-Prot:O07626" /translation="MNHKEKESVFVDLYDLYKEGELEDESMEWMKQHESLFQKNAEDL KSKTCLKRSPGAEEESQIRYMKVYLSSMYICFILLAIWMTVWFYF*" /label="ylaB CDS" gene 1456144..1456413 /gene="ylaB" /locus_tag="BSU_14720" /old_locus_tag="BSU14720" /label="ylaB gene" promotor_-35 1456379..1456383 /Source="Nicolas_upshift_promotors" /id="U1224" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.312687312687313" /psig="0.985014985014985" /xcortree=2008 /SigmaFactorBS="gtcttccatgtatatctgtttcattttatTGGCCaTTtggat gacggTGTGGTTTTATTTTTAATGAagcatagggattccattgaggacttgtatcggc a" /listShort="ylaC, ylaD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1456397..1456416 /Source="Nicolas_upshift_promotors" /id="U1224" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.312687312687313" /psig="0.985014985014985" /xcortree=2008 /SigmaFactorBS="gtcttccatgtatatctgtttcattttatTGGCCaTTtggat gacggTGTGGTTTTATTTTTAATGAagcatagggattccattgaggacttgtatcggc a" /listShort="ylaC, ylaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1456410 /Source="Nicolas_upshifts" /id="U1224" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.312687312687313" /psig="0.985014985014985" /xcortree=2008 /SigmaFactorBS="gtcttccatgtatatctgtttcattttatTGGCCaTTtggat gacggTGTGGTTTTATTTTTAATGAagcatagggattccattgaggacttgtatcggc a" /listShort="ylaC, ylaD" /GFF_Attribute="listLong" /label="upshifts" CDS 1456413..1456934 /gene="sigP" /locus_tag="BSU_14730" /old_locus_tag="BSU14730" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16501307, 16728958, 20817771" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16501307, 16728958, 20817771; Product type r: regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase ECF-type sigma factor" /protein_id="NP_389356.1" /db_xref="EnsemblGenomes-Gn:BSU14730" /db_xref="EnsemblGenomes-Tr:CAB13346" /db_xref="GOA:O07627" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013249" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR014296" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG13340" /db_xref="UniProtKB/Swiss-Prot:O07627" /translation="MKHRDSIEDLYRQYYQEILNYLFRRTHHLETAKDLAQDTFVKAL NGLASFRGHSSIRTWLYTIAHHTFINWYRRDVKYQFTEISKNEGLTQTTYDQPEQYLS RTVKSETLRQELLKLKDQHQSVLILREFQELSYEEIAEILGWSLSKVNTTLHRARLEL KKNMTKSREEERI*" /label="sigP CDS" gene 1456413..1456934 /gene="sigP" /locus_tag="BSU_14730" /old_locus_tag="BSU14730" /label="sigP gene" CDS 1456931..1457224 /gene="sigQ" /locus_tag="BSU_14740" /old_locus_tag="BSU14740" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16501307, 16728958, 20817771" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16501307, 16728958, 20817771; Product type r: regulator" /codon_start=1 /transl_table=11 /product="anti-SigP(YlaC) sigma factor" /protein_id="NP_389357.1" /db_xref="EnsemblGenomes-Gn:BSU14740" /db_xref="EnsemblGenomes-Tr:CAB13347" /db_xref="GOA:O07628" /db_xref="InterPro:IPR027383" /db_xref="SubtiList:BG13341" /db_xref="UniProtKB/Swiss-Prot:O07628" /translation="MTCFLVRDLLPLYLEGDCKRETEHVIEEHLKMCSSCRDMYDTMA EPFELESEQAVEEAYLPEEELRFKQRYYGLLIMKAACWFGAAVAMMLIIKLLI*" /label="sigQ CDS" gene 1456931..1457224 /gene="sigQ" /locus_tag="BSU_14740" /old_locus_tag="BSU14740" /label="sigQ gene" CDS complement(1457264..1457875) /gene="ylaE" /locus_tag="BSU_14750" /old_locus_tag="BSU14750" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_389358.1" /db_xref="EnsemblGenomes-Gn:BSU14750" /db_xref="EnsemblGenomes-Tr:CAB13348" /db_xref="SubtiList:BG13342" /db_xref="UniProtKB/Swiss-Prot:O07629" /translation="MKKTFVKKAMLTTAAMTSAALLTFGPDAASAKTPVDNTAVQLQH QASTNEDLNTFIDILNQCIYEQDGVYYFDSEKAVELGMTKEEAQVIATLWESTSEFFS IVSQCVYLEDGNYKFDTEKAVELGFTEKEALALEQFFSAVSLKIHILQAAIVLQDDVY SYDKDAALQAGATPLQADVYEKLFSALSQEQLAAIYDMIHPQA*" /label="ylaE CDS" gene complement(1457264..1457875) /gene="ylaE" /locus_tag="BSU_14750" /old_locus_tag="BSU14750" /label="ylaE gene" downshifts complement(1457278) /Source="Nicolas_upshifts" /id="D831" /incds=0 /nref=44 /ntot=184 /MaxReadThrough="1.37453" /MaxDrop="4.23106" /score="20.8244305" /energy="-11.7" /TU="NA" /idTUdmin="U1225" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1457907..1457926) /Source="Nicolas_upshift_promotors" /id="U1225" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.616383616383616" /psig="0.956043956043956" /xcortree=3078 /SigmaFactorBS="ggcaacgatacacataaaataccatagcgcctATTCctccac cggaaactACTCCCTATAATGGAATTTGtagcacaattcataaaagggagagaagaaa c" /listShort="ylaE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1457916) /Source="Nicolas_upshifts" /id="U1225" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.616383616383616" /psig="0.956043956043956" /xcortree=3078 /SigmaFactorBS="ggcaacgatacacataaaataccatagcgcctATTCctccac cggaaactACTCCCTATAATGGAATTTGtagcacaattcataaaagggagagaagaaa c" /listShort="ylaE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1457941..1457944) /Source="Nicolas_upshift_promotors" /id="U1225" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.616383616383616" /psig="0.956043956043956" /xcortree=3078 /SigmaFactorBS="ggcaacgatacacataaaataccatagcgcctATTCctccac cggaaactACTCCCTATAATGGAATTTGtagcacaattcataaaagggagagaagaaa c" /listShort="ylaE" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(1458131) /Source="Nicolas_upshifts" /id="D832" /incds=0 /nref=18 /ntot=138 /MaxReadThrough="2.72081" /MaxDrop="5.25382" /score="5.78870736" /energy="-8.3" /TU="NA" /idTUdmin="U1226" /TUdmin="-17" /isTUend="TRUE" /label="downshifts" CDS complement(1458148..1458336) /gene="ylaF" /locus_tag="BSU_14760" /old_locus_tag="BSU14760" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389359.1" /db_xref="EnsemblGenomes-Gn:BSU14760" /db_xref="EnsemblGenomes-Tr:CAB13349" /db_xref="GOA:O07630" /db_xref="InterPro:IPR035211" /db_xref="SubtiList:BG13343" /db_xref="UniProtKB/Swiss-Prot:O07630" /translation="MKKMNWLLLLFAFAAVFSIMLIGVFIAEKSPAGIIASIVLVCAV MGGGFTLKKKMREQGLLD*" /label="ylaF CDS" gene complement(1458148..1458336) /gene="ylaF" /locus_tag="BSU_14760" /old_locus_tag="BSU14760" /label="ylaF gene" downshifts complement(1458202) /Source="Nicolas_upshifts" /id="D833" /incds=0 /nref=9 /ntot=204 /MaxReadThrough="4.38484" /MaxDrop="3.2214" /score="5.78870736" /energy="-8.3" /TU="U1226" /idTUdmin="U1226" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1458358..1458377) /Source="Nicolas_upshift_promotors" /id="U1226" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig=1 /xcortree=3095 /SigmaFactorBS="aaaaaaattagataactttcatattatatcacacatccTCTT TAAAagcgtcacgtttTTCTGTAAACTTAATATAAGacgtaaaaggggatggaattta t" /listShort="ylaF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1458375) /Source="Nicolas_upshifts" /id="U1226" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig=1 /xcortree=3095 /SigmaFactorBS="aaaaaaattagataactttcatattatatcacacatccTCTT TAAAagcgtcacgtttTTCTGTAAACTTAATATAAGacgtaaaaggggatggaattta t" /listShort="ylaF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1458390..1458397) /Source="Nicolas_upshift_promotors" /id="U1226" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig=1 /xcortree=3095 /SigmaFactorBS="aaaaaaattagataactttcatattatatcacacatccTCTT TAAAagcgtcacgtttTTCTGTAAACTTAATATAAGacgtaaaaggggatggaattta t" /listShort="ylaF" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 1458403..1458422 /Source="Nicolas_upshift_promotors" /id="U1227" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.63936063936064" /psig=1 /xcortree=2497 /SigmaFactorBS="ttttacgtcttatattaagtttacagaaaaacgtgacgcttt taaagaggatgTGTGATATAATATGAAAGTTatctaatttttttaggagatgaaaaag t" /listShort="bipA, ylaH" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1458410 /Source="Nicolas_upshifts" /id="U1227" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.63936063936064" /psig=1 /xcortree=2497 /SigmaFactorBS="ttttacgtcttatattaagtttacagaaaaacgtgacgcttt taaagaggatgTGTGATATAATATGAAAGTTatctaatttttttaggagatgaaaaag t" /listShort="bipA, ylaH" /GFF_Attribute="listLong" /label="upshifts" CDS 1458449..1460287 /gene="bipA" /locus_tag="BSU_14770" /old_locus_tag="BSU14770" /function="16.3: Control" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11683274, 12399512, 9642082, 25135187, 26283392; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribosome-associated GTPase" /protein_id="NP_389360.1" /db_xref="EnsemblGenomes-Gn:BSU14770" /db_xref="EnsemblGenomes-Tr:CAB13350" /db_xref="GOA:O07631" /db_xref="InterPro:IPR000640" /db_xref="InterPro:IPR000795" /db_xref="InterPro:IPR004161" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR006298" /db_xref="InterPro:IPR009000" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031157" /db_xref="InterPro:IPR035647" /db_xref="InterPro:IPR035651" /db_xref="SubtiList:BG13344" /db_xref="UniProtKB/Swiss-Prot:O07631" /translation="MKLRNDLRNIAIIAHVDHGKTTLVDQLLHQAGTFRANEQVAERA MDSNDLERERGITILAKNTAINYKDTRINILDTPGHADFGGEVERIMKMVDGVVLVVD AYEGCMPQTRFVLKKALEQNLNPVVVVNKIDRDFARPEEVIDEVLDLFIELDANEEQL EFPVVYASAINGTASLDPKQQDENMEALYETIIKHVPAPVDNAEEPLQFQVALLDYND YVGRIGIGRVFRGTMKVGQQVSLMKLDGTAKSFRVTKIFGFQGLKRVEIEEAKAGDLV AVSGMEDINVGETVCPVDHQDPLPVLRIDEPTLQMTFVVNNSPFAGREGKYVTARKIE ERLQSQLQTDVSLRVEPTASPDAWVVSGRGELHLSILIENMRREGYELQVSKPEVIIK EIDGVRCEPVERVQIDVPEEHTGSVMESMGARKGEMVDMINNGNGQVRLIFTVPSRGL IGYSTEFLSLTRGFGILNHTFDSYQPMQAGQVGGRRQGVLVSMENGKATSYGIQGIED RGVIFVEPGTEVYEGMIVGEHNRDNDLVVNVSKMKQQTNVRSATKDQTTTIKKARIMS LEESLEYLNEDEYCEVTPESIRLRKKILNKNEREKAAKKKKTAGLS*" /label="bipA CDS" gene 1458449..1460287 /gene="bipA" /locus_tag="BSU_14770" /old_locus_tag="BSU14770" /label="bipA gene" CDS 1460344..1460661 /gene="ylaH" /locus_tag="BSU_14780" /old_locus_tag="BSU14780" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unkown function" /protein_id="NP_389361.1" /db_xref="EnsemblGenomes-Gn:BSU14780" /db_xref="EnsemblGenomes-Tr:CAB13351" /db_xref="GOA:O07632" /db_xref="InterPro:IPR025620" /db_xref="SubtiList:BG13345" /db_xref="UniProtKB/Swiss-Prot:O07632" /translation="MNDVSERLSFFAALYQVDRQPAAGMWLLYGTIFVLAVIVFKLGF AKRLPVLKSAVVYVFLALGCTVLTFLGVFLPVAEGLVVAALILIIYKIRLYQSKKGQS AKS*" /label="ylaH CDS" gene 1460344..1460661 /gene="ylaH" /locus_tag="BSU_14780" /old_locus_tag="BSU14780" /label="ylaH gene" downshifts 1460635 /Source="Nicolas_upshifts" /id="D834" /incds=0 /nref=241 /ntot=297 /MaxReadThrough="2.76511" /MaxDrop="7.50514" /score="29.8701447" /energy="-12.5" /TU="NA" /idTUdmin="U1227" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" downshifts complement(1460710) /Source="Nicolas_upshifts" /id="D835" /incds=0 /nref=240 /ntot=265 /MaxReadThrough="0.672690000000001" /MaxDrop="7.03405" /score="10.4340016" /energy="-12.5" /TU="NA" /idTUdmin="U1228" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1460717..1460926) /gene="ylaI" /locus_tag="BSU_14790" /old_locus_tag="BSU14790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389362.1" /db_xref="EnsemblGenomes-Gn:BSU14790" /db_xref="EnsemblGenomes-Tr:CAB13352" /db_xref="InterPro:IPR019241" /db_xref="SubtiList:BG13346" /db_xref="UniProtKB/Swiss-Prot:O07633" /translation="MMRVKCSICDKIETIDDDTLIAKRLRNRPIHTYMCQECHDRIAK KTEERLKTGKFTFHPGQQKKEKVKK*" /label="ylaI CDS" gene complement(1460717..1460926) /gene="ylaI" /locus_tag="BSU_14790" /old_locus_tag="BSU14790" /label="ylaI gene" misc_feature complement(1460940..1460959) /Source="Nicolas_upshift_promotors" /id="U1228" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.742257742257742" /psig=1 /xcortree=1900 /SigmaFactorBS="tgactaagctatagccttgcgctttagctttttcttattttg gacagcttctgatcCGTGGTATAATACATGTTAGtgaaagaggtgatatgatgagggt c" /listShort="ylaI" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1460955) /Source="Nicolas_upshifts" /id="U1228" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.742257742257742" /psig=1 /xcortree=1900 /SigmaFactorBS="tgactaagctatagccttgcgctttagctttttcttattttg gacagcttctgatcCGTGGTATAATACATGTTAGtgaaagaggtgatatgatgagggt c" /listShort="ylaI" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1461009..1461638) /gene="ylaJ" /locus_tag="BSU_14800" /old_locus_tag="BSU14800" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 28333204; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative germination lipoprotein" /protein_id="NP_389363.1" /db_xref="EnsemblGenomes-Gn:BSU14800" /db_xref="EnsemblGenomes-Tr:CAB13353" /db_xref="GOA:O07634" /db_xref="InterPro:IPR014247" /db_xref="InterPro:IPR015943" /db_xref="InterPro:IPR019076" /db_xref="SubtiList:BG13347" /db_xref="UniProtKB/Swiss-Prot:O07634" /translation="MRILFIIIQLTLILSACAYQQGKQGQNVEKESTRQQETKPIHVK DTTQETKDNGTRTDIAKHLVSVAEKNPDVKDATAVVLGGYAVVGIDVDDTLDRSKVET IKYSVAQALKNDRYGANAVVIADPDTVSRLREMSREISEGHPVTGILDELAAIVGRVL PEVPNDVIDNEDEPQTKQQNDQLNRKQQQEMEKEQNDQSDHHMKKNNND*" /label="ylaJ CDS" gene complement(1461009..1461638) /gene="ylaJ" /locus_tag="BSU_14800" /old_locus_tag="BSU14800" /label="ylaJ gene" downshifts complement(1461040) /Source="Nicolas_upshifts" /id="D836" /incds=0 /nref=57 /ntot=112 /MaxReadThrough="1.90936" /MaxDrop="5.8475" /score="3.85709048" /energy="-7.2" /TU="NA" /idTUdmin="U1229" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1461540..1461558) /Source="Nicolas_upshift_promotors" /id="U1229" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=545 /SigmaFactorBS="acttatcctgtccgcttgtgcctatcaaCAAGGAAAAcaggg ccagaaTGTTGAAAAAGAATCAACAagacagcaggagactaaaccgattcacgtaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1461546) /Source="Nicolas_upshifts" /id="U1229" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=545 /SigmaFactorBS="acttatcctgtccgcttgtgcctatcaaCAAGGAAAAcaggg ccagaaTGTTGAAAAAGAATCAACAagacagcaggagactaaaccgattcacgtaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1461570..1461578) /Source="Nicolas_upshift_promotors" /id="U1229" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=545 /SigmaFactorBS="acttatcctgtccgcttgtgcctatcaaCAAGGAAAAcaggg ccagaaTGTTGAAAAAGAATCAACAagacagcaggagactaaaccgattcacgtaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1461673..1461684) /Source="Nicolas_upshift_promotors" /id="U1230" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=936 /SigmaFactorBS="aaaggtgaatgcctgctaaaatatatgtttttgTGCATAAag atagaaggttaaTTCAACAATAAAattaatgaaagcattttaaggagggaacccgcaa g" /listShort="ylaJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1461678) /Source="Nicolas_upshifts" /id="U1230" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=936 /SigmaFactorBS="aaaggtgaatgcctgctaaaatatatgtttttgTGCATAAag atagaaggttaaTTCAACAATAAAattaatgaaagcattttaaggagggaacccgcaa g" /listShort="ylaJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1461690..1461695 /Source="Nicolas_upshift_promotors" /id="U1231" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1153 /SigmaFactorBS="tccttaaaatgctttcattaattttattgttgaattaacCTT CTAtctttatgcacaaaaACATATATTTTAGCAGGCAttcacctttttcatcaaaaga g" /listShort="S538, ylaK, S540, glsB" /listLong="ylaN, S541, ftsW, pycA" /label="promotor_-35" promotor_-35 complement(1461699..1461705) /Source="Nicolas_upshift_promotors" /id="U1230" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=936 /SigmaFactorBS="aaaggtgaatgcctgctaaaatatatgtttttgTGCATAAag atagaaggttaaTTCAACAATAAAattaatgaaagcattttaaggagggaacccgcaa g" /listShort="ylaJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1461711..1461729 /Source="Nicolas_upshift_promotors" /id="U1231" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1153 /SigmaFactorBS="tccttaaaatgctttcattaattttattgttgaattaacCTT CTAtctttatgcacaaaaACATATATTTTAGCAGGCAttcacctttttcatcaaaaga g" /listShort="S538, ylaK, S540, glsB" /listLong="ylaN, S541, ftsW, pycA" /label="promotor_-10" upshifts 1461711 /Source="Nicolas_upshifts" /id="U1231" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1153 /SigmaFactorBS="tccttaaaatgctttcattaattttattgttgaattaacCTT CTAtctttatgcacaaaaACATATATTTTAGCAGGCAttcacctttttcatcaaaaga g" /listShort="S538, ylaK, S540, glsB" /listLong="ylaN, S541, ftsW, pycA" /label="upshifts" S_feature 1461712..1461792 /Source="Nicolas_S_feature" /locus_tag="new_1549384_1549464" /HighExp="S3, S5, S4, S8, S6, S7, LoTm, T5.0H, B36, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S538" CDS 1461793..1463121 /gene="ylaK" /locus_tag="BSU_14810" /old_locus_tag="BSU14810" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12762842, 17114254; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative phosphate starvation inducible protein" /protein_id="NP_389364.1" /db_xref="EnsemblGenomes-Gn:BSU14810" /db_xref="EnsemblGenomes-Tr:CAB13354" /db_xref="GOA:O07635" /db_xref="InterPro:IPR002716" /db_xref="InterPro:IPR003714" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR029060" /db_xref="SubtiList:BG13348" /db_xref="UniProtKB/Swiss-Prot:O07635" /translation="MSKIYVLDTNVLLQDPNAIFSFEENEVVIPAVVLEEVDSKKRYM DEVGRNARHVSKLIDALRQKGRLHEHVPLDTGGTLRIELNHRSFHQLQEIFIEKTNDN RILAVAKNLSLEEETKENGRPVILVSKDVLVRVKADAIGLLAEDFLNDRVVDNDEMYS GYKDLYISQQLFSSFYGKNQISVNDVKQHAFYPNQFALMKDELGGSSSAVGIADKTGT VLKRLVFDDEHIWGIRPKNVQQTMALELLLREDIPLVTLIGKAGTGKTLLALAAGLLQ TEDLGIYKKLVVARPIVPVGKDIGYLPGEKEEKLKPWMQPIFDNLEFLFNAKKPGELD AILAGIGSIQVEALTYIRGRSIPDQFIIIDEAQNLTRHEVKTLLTRVGEGSKIVLMGD PEQIDHPYLDSLNNGLAYVVERFKGQPISGSVKLLKGERSGLAQLAADLL*" /label="ylaK CDS" gene 1461793..1463121 /gene="ylaK" /locus_tag="BSU_14810" /old_locus_tag="BSU14810" /label="ylaK gene" S_feature complement(1462977..1463124) /Source="Nicolas_S_feature" /locus_tag="new_1550649_1550796_c" /HighExp="M40t90, M0t90, dia15, Lbtran, dia5, Etha, Mt0, Gly, LBGtran, LPhT" /AntisenseName="ylaK" /AntisenseCor="-0.66426410013570203" /AntisenseRegPval="-34.9" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S539" downshifts complement(1463020) /Source="Nicolas_upshifts" /id="D837" /incds=1 /nref=6 /ntot=67 /MaxReadThrough="3.81309" /MaxDrop="3.44499" /score="3.85709048" /energy="-7.2" /TU="U1232" /idTUdmin="U1232" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" S_feature 1463122..1463712 /Source="Nicolas_S_feature" /locus_tag="new_1550794_1551384" /HighExp="S3, S4, S6, S5, S8, S7, BT, B36, LoTm, T5.0H" /AntisenseName="ylaL" /AntisenseCor="-0.79954210237955903" /AntisenseRegPval="-60.3" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S540" CDS complement(1463125..1463610) /gene="ylaL" /locus_tag="BSU_14820" /old_locus_tag="BSU14820" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389365.1" /db_xref="EnsemblGenomes-Gn:BSU14820" /db_xref="EnsemblGenomes-Tr:CAB13355" /db_xref="GOA:O07636" /db_xref="InterPro:IPR020229" /db_xref="InterPro:IPR036374" /db_xref="SubtiList:BG13349" /db_xref="UniProtKB/Swiss-Prot:O07636" /translation="MSVIQVKGNVTYPITIDPSVWIFDDRKFSFDRKGDSQDTYLQSA GDESDLDPERVIREGRIAPPTLKTEKQYEKQKLMNGSFAMRLGTVLKNAEPNSSATQC VFVTSSGKAAVSLETALNSIVHFSEAGKPIQEGGPVHIYFEDPVHHKQPITDVKEIEI I*" /label="ylaL CDS" gene complement(1463125..1463610) /gene="ylaL" /locus_tag="BSU_14820" /old_locus_tag="BSU14820" /label="ylaL gene" promotor_-10 complement(1463622..1463641) /Source="Nicolas_upshift_promotors" /id="U1232" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.921078921078921" /psig="0.987012987012987" /xcortree=2208 /SigmaFactorBS="aaacaccctcgttccctcagcatttcaatacacataatttgt acacaAAGTGACAattcatgcgaaaacTTTTATAATTTTGAGAGAAGggggtcatatc a" /listShort="ylaL, S539" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1463650) /Source="Nicolas_upshifts" /id="U1232" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.921078921078921" /psig="0.987012987012987" /xcortree=2208 /SigmaFactorBS="aaacaccctcgttccctcagcatttcaatacacataatttgt acacaAAGTGACAattcatgcgaaaacTTTTATAATTTTGAGAGAAGggggtcatatc a" /listShort="ylaL, S539" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1463656..1463663) /Source="Nicolas_upshift_promotors" /id="U1232" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.921078921078921" /psig="0.987012987012987" /xcortree=2208 /SigmaFactorBS="aaacaccctcgttccctcagcatttcaatacacataatttgt acacaAAGTGACAattcatgcgaaaacTTTTATAATTTTGAGAGAAGggggtcatatc a" /listShort="ylaL, S539" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1463713..1464642 /gene="glsB" /locus_tag="BSU_14830" /old_locus_tag="BSU14830" /EC_number="3.5.1.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:18459799" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18459799; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-glutamine amidohydrolase; glutaminase" /protein_id="NP_389366.1" /db_xref="EnsemblGenomes-Gn:BSU14830" /db_xref="EnsemblGenomes-Tr:CAB13356" /db_xref="GOA:O07637" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR015868" /db_xref="SubtiList:BG13350" /db_xref="UniProtKB/Swiss-Prot:O07637" /translation="MVCQHNDELEALVKKAKKVTDKGEVASYIPALAKADKHDLSVAI YYSNNVCLSAGDVEKTFTLQSISKVLSLALVLMEYGKDKVFSYVGQEPTGDPFNSIIK LETVNPSKPLNPMINAGALVVTSLIRGRTVKERLDYLLSFIRRLTNNQEITYCREVAE SEYSTSMINRAMCYYMKQYGIFEDDVEAVMDLYTKQCAIEMNSLDLAKIGSVFALNGR HPETGEQVISKDVARICKTFMVTCGMYNASGEFAIKVGIPAKSGVSGGIMGISPYDFG IGIFGPALDEKGNSIAGVKLLEIMSEMYRLSIF*" /label="glsB CDS" gene 1463713..1464642 /gene="glsB" /locus_tag="BSU_14830" /old_locus_tag="BSU14830" /label="glsB gene" misc_feature 1464227..1464246 /Source="Nicolas_upshift_promotors" /id="U1233" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.9000999000999" /psig="0.99100899100899" /xcortree=596 /SigmaFactorBS="gccgggaagtggctgaatctgaatacagcacttcaatgatta atcgggcgaTGTGTTATTATATGAAGCAGtacggcatttttgaagatgatgtagaggc a" /GFF_Attribute="listShort" /listLong="ylaN" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1464236 /Source="Nicolas_upshifts" /id="U1233" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.9000999000999" /psig="0.99100899100899" /xcortree=596 /SigmaFactorBS="gccgggaagtggctgaatctgaatacagcacttcaatgatta atcgggcgaTGTGTTATTATATGAAGCAGtacggcatttttgaagatgatgtagaggc a" /GFF_Attribute="listShort" /listLong="ylaN" /label="upshifts" promotor_-35 1464666..1464669 /Source="Nicolas_upshift_promotors" /id="U1234" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig=1 /xcortree=413 /SigmaFactorBS="gtattttttaatttatgtcatatgcttaaatcctCTTGcatt ttctgttgatACCCTTTATGATAAATAGAAgaattaggtactcgcctggggaacggag g" /listShort="ylaN, S541, ftsW, pycA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1464684..1464703 /Source="Nicolas_upshift_promotors" /id="U1234" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig=1 /xcortree=413 /SigmaFactorBS="gtattttttaatttatgtcatatgcttaaatcctCTTGcatt ttctgttgatACCCTTTATGATAAATAGAAgaattaggtactcgcctggggaacggag g" /listShort="ylaN, S541, ftsW, pycA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1464692 /Source="Nicolas_upshifts" /id="U1234" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig=1 /xcortree=413 /SigmaFactorBS="gtattttttaatttatgtcatatgcttaaatcctCTTGcatt ttctgttgatACCCTTTATGATAAATAGAAgaattaggtactcgcctggggaacggag g" /listShort="ylaN, S541, ftsW, pycA" /GFF_Attribute="listLong" /label="upshifts" CDS 1464740..1465021 /gene="ylaN" /locus_tag="BSU_14840" /old_locus_tag="BSU14840" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12682299, 16880555, 17005971,17469204" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389367.1" /db_xref="EnsemblGenomes-Gn:BSU14840" /db_xref="EnsemblGenomes-Tr:CAB13357" /db_xref="InterPro:IPR009983" /db_xref="InterPro:IPR036270" /db_xref="SubtiList:BG13351" /db_xref="UniProtKB/Swiss-Prot:O07638" /translation="MASEMIVDHRQKAFELLKVDAEKILKLIRVQMDNLTMPQCPLYE EVLDTQMFGLSREIDFAVRLGLVDEKDGKDLLYTLERELSALHDAFTAK*" /label="ylaN CDS" gene 1464740..1465021 /gene="ylaN" /locus_tag="BSU_14840" /old_locus_tag="BSU14840" /label="ylaN gene" downshifts 1465010 /Source="Nicolas_upshifts" /id="D838" /incds=0 /nref=72 /ntot=227 /MaxReadThrough="5.3857" /MaxDrop="6.58793" /score="2.26145837" /energy="-6.9" /TU="U1234" /idTUdmin="U1231" /TUdmin=328 /isTUend="FALSE" /label="downshifts" promotor_-35 1465084..1465087 /Source="Nicolas_upshift_promotors" /id="U1235" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.619380619380619" /psig="0.619380619380619" /xcortree=1767 /SigmaFactorBS="attaacagtttgggtttttttataaccgctatttttctctca tcTCATaaaagacggtcttttttTACACATtccttccgaatcgtatagagattcttcg t" /listShort="S541, ftsW, pycA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1465100..1465226 /Source="Nicolas_S_feature" /locus_tag="new_1552772_1552898" /HighExp="S1, T5.0H, T4.0H, HiOs, T3.30H, T3.0H, Etha, Heat, T2.0H, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigI, SigA" /TUshortPSig="0.619, 1" /TUlongSig="SigEF" /TUlongPSig="0.999" /label="S541" upshifts 1465100 /Source="Nicolas_upshifts" /id="U1235" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.619380619380619" /psig="0.619380619380619" /xcortree=1767 /SigmaFactorBS="attaacagtttgggtttttttataaccgctatttttctctca tcTCATaaaagacggtcttttttTACACATtccttccgaatcgtatagagattcttcg t" /listShort="S541, ftsW, pycA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1465105..1465111 /Source="Nicolas_upshift_promotors" /id="U1235" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.619380619380619" /psig="0.619380619380619" /xcortree=1767 /SigmaFactorBS="attaacagtttgggtttttttataaccgctatttttctctca tcTCATaaaagacggtcttttttTACACATtccttccgaatcgtatagagattcttcg t" /listShort="S541, ftsW, pycA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1465227..1466438 /gene="ftsW" /locus_tag="BSU_14850" /old_locus_tag="BSU14850" /function="16.13: Shape" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9622350, 12626683, 15849754, 16850406, 21386816, 27895631" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9622350, 12626683, 15849754, 16850406, 21386816, 27895631; Product type t : transporter" /codon_start=1 /transl_table=11 /product="cell-division protein; transporter of lipid-linked cell wall precursors" /protein_id="NP_389368.1" /db_xref="EnsemblGenomes-Gn:BSU14850" /db_xref="EnsemblGenomes-Tr:CAB13358" /db_xref="GOA:O07639" /db_xref="InterPro:IPR001182" /db_xref="InterPro:IPR018365" /db_xref="SubtiList:BG13352" /db_xref="UniProtKB/Swiss-Prot:O07639" /translation="MLKKMLKSYDYSLIFAIVLLCGFGLVMVYSSSMITAVSRYGVSS NFFFMRQLFALIAGGALFILMALFPYKALAHQKFQKGILLVSVLALISLFVFGHVAGN AQSWFKIGGMSIQPGEFVKLVVILYLAAVYAKKQSYIDHLLTGVAPPVVMTLIICGLI AMQPDFGTAMIIGLIATCMILCSGFSGKTLVRLVILGGIVFILVSPIIYLNQDKILTE GRLARFESLEDPFKYANSSGLQVINSYYAISSGGIFGLGLGESIQKYGYLPESHTDFI MAVIAEELGIFGVLFVIFLLGFVVIKGFYIARKCEDPFGSLLAIGISSMIAIQSFINL GGVSGLIPITGVTLPFISYGGSSLVLLLGSMGILANISMFVKYSENKKKKEPLAPKGM KKKQLKKTVYL*" /label="ftsW CDS" gene 1465227..1466438 /gene="ftsW" /locus_tag="BSU_14850" /old_locus_tag="BSU14850" /label="ftsW gene" promotor_-35 1466448..1466452 /Source="Nicolas_upshift_promotors" /id="U1236" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.320679320679321" /psig="0.98901098901099" /xcortree=2763 /SigmaFactorBS="tgtttatctgtaaaaaacaagtGTGTAcaggggaaggatatT CCGCTATGATAGATTATATtccattcgggtaagggggagaaaagtttgtctcagcaat c" /listShort="pycA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1466467..1466486 /Source="Nicolas_upshift_promotors" /id="U1236" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.320679320679321" /psig="0.98901098901099" /xcortree=2763 /SigmaFactorBS="tgtttatctgtaaaaaacaagtGTGTAcaggggaaggatatT CCGCTATGATAGATTATATtccattcgggtaagggggagaaaagtttgtctcagcaat c" /listShort="pycA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1466486 /Source="Nicolas_upshifts" /id="U1236" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.320679320679321" /psig="0.98901098901099" /xcortree=2763 /SigmaFactorBS="tgtttatctgtaaaaaacaagtGTGTAcaggggaaggatatT CCGCTATGATAGATTATATtccattcgggtaagggggagaaaagtttgtctcagcaat c" /listShort="pycA" /GFF_Attribute="listLong" /label="upshifts" CDS 1466513..1469959 /gene="pycA" /locus_tag="BSU_14860" /old_locus_tag="BSU14860" /EC_number="6.4.1.1" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 6425269, 15134465, 20081037, 20097852; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyruvate carboxylase" /protein_id="NP_389369.1" /db_xref="EnsemblGenomes-Gn:BSU14860" /db_xref="EnsemblGenomes-Tr:CAB13359" /db_xref="GOA:Q9KWU4" /db_xref="InterPro:IPR000089" /db_xref="InterPro:IPR000891" /db_xref="InterPro:IPR003379" /db_xref="InterPro:IPR005479" /db_xref="InterPro:IPR005481" /db_xref="InterPro:IPR005482" /db_xref="InterPro:IPR005930" /db_xref="InterPro:IPR011053" /db_xref="InterPro:IPR011054" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR011764" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="SubtiList:BG12660" /db_xref="UniProtKB/Swiss-Prot:Q9KWU4" /translation="MSQQSIQKVLVANRGEIAIRIFRACTELNIRTVAVYSKEDSGSY HRYKADEAYLVGEGKKPIDAYLDIEGIIDIAKRNKVDAIHPGYGFLSENIHFARRCEE EGIVFIGPKSEHLDMFGDKVKAREQAEKAGIPVIPGSDGPAETLEAVEQFGQANGYPI IIKASLGGGGRGMRIVRSESEVKEAYERAKSEAKAAFGNDEVYVEKLIENPKHIEVQV IGDKQGNVVHLFERDCSVQRRHQKVIEVAPSVSLSPELRDQICEAAVALAKNVNYINA GTVEFLVANNEFYFIEVNPRVQVEHTITEMITGVDIVQTQILVAQGHSLHSKKVNIPE QKDIFTIGYAIQSRVTTEDPQNDFMPDTGKIMAYRSGGGFGVRLDTGNSFQGAVITPY YDSLLVKLSTWALTFEQAAAKMVRNLQEFRIRGIKTNIPFLENVAKHEKFLTGQYDTS FIDTTPELFNFPKQKDRGTKMLTYIGNVTVNGFPGIGKKEKPAFDKPLGVKVDVDQQP ARGTKQILDEKGAEGLANWVKEQKSVLLTDTTFRDAHQSLLATRIRSHDLKKIANPTA ALWPELFSMEMWGGATFDVAYRFLKEDPWKRLEDLRKEVPNTLFQMLLRSSNAVGYTN YPDNVIKEFVKQSAQSGIDVFRIFDSLNWVKGMTLAIDAVRDTGKVAEAAICYTGDIL DKNRTKYDLAYYTSMAKELEAAGAHILGIKDMAGLLKPQAAYELVSALKETIDIPVHL HTHDTSGNGIYMYAKAVEAGVDIIDVAVSSMAGLTSQPSASGFYHAMEGNDRRPEMNV QGVELLSQYWESVRKYYSEFESGMKSPHTEIYEHEMPGGQYSNLQQQAKGVGLGDRWN EVKEMYRRVNDMFGDIVKVTPSSKVVGDMALYMVQNNLTEKDVYEKGESLDFPDSVVE LFKGNIGQPHGGFPEKLQKLILKGQEPITVRPGELLEPVSFEAIKQEFKEQHNLEISD QDAVAYALYPKVFTDYVKTTESYGDISVLDTPTFFYGMTLGEEIEVEIERGKTLIVKL ISIGEPQPDATRVVYFELNGQPREVVIKDESIKSSVQERLKADRTNPSHIAASMPGTV IKVLAEAGTKVNKGDHLMINEAMKMETTVQAPFSGTIKQVHVKNGEPIQTGDLLLEIE KA*" /label="pycA CDS" gene 1466513..1469959 /gene="pycA" /locus_tag="BSU_14860" /old_locus_tag="BSU14860" /label="pycA gene" promotor_-10 complement(1469525..1469543) /Source="Nicolas_upshift_promotors" /id="U1237" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=1065 /SigmaFactorBS="aatcagcttaacgatcagcgttttgccgcgctcaatttcaaC TTCTAtctcttcacctaatgTCATACCGTAGAAGAATGTcggtgtatctaataccgag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1469545) /Source="Nicolas_upshifts" /id="U1237" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=1065 /SigmaFactorBS="aatcagcttaacgatcagcgttttgccgcgctcaatttcaaC TTCTAtctcttcacctaatgTCATACCGTAGAAGAATGTcggtgtatctaataccgag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1469559..1469564) /Source="Nicolas_upshift_promotors" /id="U1237" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=1065 /SigmaFactorBS="aatcagcttaacgatcagcgttttgccgcgctcaatttcaaC TTCTAtctcttcacctaatgTCATACCGTAGAAGAATGTcggtgtatctaataccgag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1469939 /Source="Nicolas_upshifts" /id="D839" /incds=0 /nref=20 /ntot=213 /MaxReadThrough="5.5667" /MaxDrop="6.03063" /score="0.893081758" /energy="-11.8" /TU="U1236" /idTUdmin="U1234" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" downshifts 1469984 /Source="Nicolas_upshifts" /id="D840" /incds=0 /nref=2 /ntot=51 /MaxReadThrough="4.21552" /MaxDrop="4.9051" /score="0.893081758" /energy="-11.8" /TU="U1236" /idTUdmin="U1234" /TUdmin=44 /isTUend="FALSE" /label="downshifts" downshifts complement(1470016) /Source="Nicolas_upshifts" /id="D841" /incds=0 /nref=2 /ntot=10 /MaxReadThrough="2.24992" /MaxDrop="3.11732" /score="10.1921506" /energy="-11.8" /TU="NA" /idTUdmin="U1238" /TUdmin=330 /isTUend="FALSE" /label="downshifts" downshifts 1470028 /Source="Nicolas_upshifts" /id="D842" /incds=0 /nref=1 /ntot=2 /MaxReadThrough="3.6246" /MaxDrop="4.10361" /score="0.893081758" /energy="-11.8" /TU="U1236" /idTUdmin="U1234" /TUdmin=88 /isTUend="FALSE" /label="downshifts" CDS complement(1470362..1471282) /gene="ctaA" /locus_tag="BSU_14870" /old_locus_tag="BSU14870" /EC_number="1.3.-.-" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:12206660, 15491161, 15849754, 16321940, 16850406, 26592143" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12206660, 15491161, 15849754, 16321940, 16850406, 26592143; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="heme-A synthase" /protein_id="NP_389370.1" /db_xref="EnsemblGenomes-Gn:BSU14870" /db_xref="EnsemblGenomes-Tr:CAB13360" /db_xref="GOA:P12946" /db_xref="InterPro:IPR003780" /db_xref="InterPro:IPR023755" /db_xref="SubtiList:BG10213" /db_xref="UniProtKB/Swiss-Prot:P12946" /translation="MNKALKALGVLTTFVMLIVLIGGALVTKTGSGQGCGRQWPLCHG RFFPELNPASIIEWSHRFASGISIILVLSLAFWSWRKITPIFRETTFLAIMSIIFLFL QALLGALAVVFGSNALIMALHFGISLISFASVLILTLLIFEADKSVRTLVKPLQIGKK MQFHMIGILIYSYIVVYTGAYVRHTESSLACPNVPLCSPLNNGLPTQFHEWVQMGHRA AALLLFVWIIVAAVHAITSYKDQKQIFWGWISCLIFITLQALSGIMIVYSELALGFAL AHSFFIACLFGVLCYFLLLIARFRYESRQS*" /label="ctaA CDS" gene complement(1470362..1471282) /gene="ctaA" /locus_tag="BSU_14870" /old_locus_tag="BSU14870" /label="ctaA gene" downshifts complement(1470368) /Source="Nicolas_upshifts" /id="D843" /incds=0 /nref=126 /ntot=238 /MaxReadThrough="2.72676" /MaxDrop="5.67271" /score="28.8671863" /energy="-15.3" /TU="U1238" /idTUdmin="U1238" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1471322..1471341) /Source="Nicolas_upshift_promotors" /id="U1238" /multdbtbs="SigA,SigE" /comp="M19" /sig="SigA" /pcomp="0.833166833166833" /psig=1 /xcortree=1626 /SigmaFactorBS="cattctattatatttttgtgaacaaaaggctctggGAATTGC CacaaaacacatatTCGCTTACACTTGGAACGTAtataaaattgcagcagtatgttaa g" /listShort="ctaA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1471337) /Source="Nicolas_upshifts" /id="U1238" /multdbtbs="SigA,SigE" /comp="M19" /sig="SigA" /pcomp="0.833166833166833" /psig=1 /xcortree=1626 /SigmaFactorBS="cattctattatatttttgtgaacaaaaggctctggGAATTGC CacaaaacacatatTCGCTTACACTTGGAACGTAtataaaattgcagcagtatgttaa g" /listShort="ctaA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1471355..1471362) /Source="Nicolas_upshift_promotors" /id="U1238" /multdbtbs="SigA,SigE" /comp="M19" /sig="SigA" /pcomp="0.833166833166833" /psig=1 /xcortree=1626 /SigmaFactorBS="cattctattatatttttgtgaacaaaaggctctggGAATTGC CacaaaacacatatTCGCTTACACTTGGAACGTAtataaaattgcagcagtatgttaa g" /listShort="ctaA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1471417..1471424 /Source="Nicolas_upshift_promotors" /id="U1239" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.824175824175824" /psig=1 /xcortree=1603 /SigmaFactorBS="acaaaaatataatagaatgacggcttctggaaaatgtaCACT TGATtattcatgccgggTCTGATAGAAATAAGGTAAAcgcaatgccgatttggagatt g" /listShort="S542, S543, ctaB, S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1471438..1471457 /Source="Nicolas_upshift_promotors" /id="U1239" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.824175824175824" /psig=1 /xcortree=1603 /SigmaFactorBS="acaaaaatataatagaatgacggcttctggaaaatgtaCACT TGATtattcatgccgggTCTGATAGAAATAAGGTAAAcgcaatgccgatttggagatt g" /listShort="S542, S543, ctaB, S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1471439..1471544 /Source="Nicolas_S_feature" /locus_tag="new_1559111_1559216" /HighExp="LBGstat, M0t90, Lbstat, BC, T0.30H, T1.30H, B60, M9-stat, M40t90, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S542" upshifts 1471439 /Source="Nicolas_upshifts" /id="U1239" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.824175824175824" /psig=1 /xcortree=1603 /SigmaFactorBS="acaaaaatataatagaatgacggcttctggaaaatgtaCACT TGATtattcatgccgggTCTGATAGAAATAAGGTAAAcgcaatgccgatttggagatt g" /listShort="S542, S543, ctaB, S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="upshifts" S_feature 1471546..1471636 /Source="Nicolas_S_feature" /locus_tag="new_1559218_1559308" /HighExp="LBGstat, M0t90, LPhT, BC, UNK1, BI, Lbexp, LBGtran, Lbstat, ferm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.994, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S543" upshifts 1471546 /Source="Nicolas_upshifts" /id="U1240" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.977022977022977" /psig="0.994005994005994" /xcortree=2711 /SigmaFactorBS="tctttggtaaaattcataaaaagttcacaaataaattcctgt ttgtcgtttaatatttaataggatGTTTttttacaagatgttATCTTGTATGATAGAG T" /listShort="S543, ctaB, S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1471552..1471555 /Source="Nicolas_upshift_promotors" /id="U1240" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.977022977022977" /psig="0.994005994005994" /xcortree=2711 /SigmaFactorBS="tctttggtaaaattcataaaaagttcacaaataaattcctgt ttgtcgtttaatatttaataggatGTTTttttacaagatgttATCTTGTATGATAGAG T" /listShort="S543, ctaB, S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1471570..1471586 /Source="Nicolas_upshift_promotors" /id="U1240" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.977022977022977" /psig="0.994005994005994" /xcortree=2711 /SigmaFactorBS="tctttggtaaaattcataaaaagttcacaaataaattcctgt ttgtcgtttaatatttaataggatGTTTttttacaagatgttATCTTGTATGATAGAG T" /listShort="S543, ctaB, S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1471637..1472554 /gene="ctaB" /locus_tag="BSU_14880" /old_locus_tag="BSU14880" /EC_number="2.5.1.-" /function="16.10: Respire" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:8082800, 10675592, 15849754, 16850406, 7968515, 9829923, 19204012" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8082800, 10675592, 15849754, 16850406, 7968515, 9829923, 19204012; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protoheme IX farnesyltransferase 2" /protein_id="NP_389371.1" /db_xref="EnsemblGenomes-Gn:BSU14880" /db_xref="EnsemblGenomes-Tr:CAB13361" /db_xref="GOA:P24009" /db_xref="InterPro:IPR000537" /db_xref="InterPro:IPR006369" /db_xref="InterPro:IPR030470" /db_xref="SubtiList:BG10214" /db_xref="UniProtKB/Swiss-Prot:P24009" /translation="MANSRILNDTAIDGQIEETTAWKDFLSLIKIGIVNSNLITTFTG MWLALHISGLSFLGNINTVLLTLIGSSLIIAGSCAINNWYDRDIDHLMERTKVRPTVT GKIQPSQALWSGILLVALGLIMLLMTTVMAAVIGFIGVFTYVVLYTMWTKRRYTINTV VGSVSGAVPPLIGWTAVEGNIGVVAWVLFMILFIWQIPHFLALAIKKTEDYRAANIPM LPVVYGFEVTKRQIIVWVACLMPLPFFLGSLGLPIVILGLLLNIGWLILGLMGFRSKN IMKWATQMFVYSLNYMTIYFVAMVVLTLF*" /label="ctaB CDS" gene 1471637..1472554 /gene="ctaB" /locus_tag="BSU_14880" /old_locus_tag="BSU14880" /label="ctaB gene" downshifts 1472583 /Source="Nicolas_upshifts" /id="D844" /incds=0 /nref=33 /ntot=75 /MaxReadThrough="8.35391" /MaxDrop="5.6457" /score="0.893081758" /energy="-11.8" /TU="U1239,U1240" /idTUdmin="U1236" /TUdmin=1719 /isTUend="FALSE" /label="downshifts" upshifts 1472602 /Source="Nicolas_upshifts" /id="U1241" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.406593406593407" /psig="0.406593406593407" /xcortree=510 /SigmaFactorBS="gacgcttttctaaaaaatagatatgatgcttgttttatcgct tcaaaataaacgatgacaaCTAGTAaatgccgccttgacctcttgtttaatcaggcgg c" /listShort="S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="upshifts" misc_feature 1472603..1472608 /Source="Nicolas_upshift_promotors" /id="U1241" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.406593406593407" /psig="0.406593406593407" /xcortree=510 /SigmaFactorBS="gacgcttttctaaaaaatagatatgatgcttgttttatcgct tcaaaataaacgatgacaaCTAGTAaatgccgccttgacctcttgtttaatcaggcgg c" /listShort="S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-35 1472662..1472667 /Source="Nicolas_upshift_promotors" /id="U1242" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.450549450549451" /psig="0.450549450549451" /xcortree=338 /SigmaFactorBS="ttaatcaggcggctttacttttatacatagatGGCATTttga gtaaaaaaacTCATAATTTAAGAGAAGAGgaaatgtaagtgctttattggtgataggt t" /listShort="S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1472682..1472700 /Source="Nicolas_upshift_promotors" /id="U1242" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.450549450549451" /psig="0.450549450549451" /xcortree=338 /SigmaFactorBS="ttaatcaggcggctttacttttatacatagatGGCATTttga gtaaaaaaacTCATAATTTAAGAGAAGAGgaaatgtaagtgctttattggtgataggt t" /listShort="S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1472690..1472793 /Source="Nicolas_S_feature" /locus_tag="new_1560362_1560465" /HighExp="Lbstat, M0t90, M40t90, T2.30H, T3.30H, T2.0H, T3.0H, T4.0H, T1.30H, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, Sig-, SigA, SigA" /TUshortPSig="0.451, 0.407, 0.994, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S544" upshifts 1472690 /Source="Nicolas_upshifts" /id="U1242" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.450549450549451" /psig="0.450549450549451" /xcortree=338 /SigmaFactorBS="ttaatcaggcggctttacttttatacatagatGGCATTttga gtaaaaaaacTCATAATTTAAGAGAAGAGgaaatgtaagtgctttattggtgataggt t" /listShort="S544, ctaC, ctaD, ctaE, ctaF, ctaG" /GFF_Attribute="listLong" /label="upshifts" CDS 1472794..1473864 /gene="ctaC" /locus_tag="BSU_14890" /old_locus_tag="BSU14890" /EC_number="1.9.3.1" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1685007, 1847686, 9829923, 9882689, 27503613" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1685007, 1847686, 9829923, 9882689, 27503613; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome caa3 oxidase (subunit II)" /protein_id="NP_389372.1" /db_xref="EnsemblGenomes-Gn:BSU14890" /db_xref="EnsemblGenomes-Tr:CAB13362" /db_xref="GOA:P24011" /db_xref="InterPro:IPR001505" /db_xref="InterPro:IPR002429" /db_xref="InterPro:IPR008972" /db_xref="InterPro:IPR009056" /db_xref="InterPro:IPR011759" /db_xref="InterPro:IPR014222" /db_xref="InterPro:IPR034236" /db_xref="InterPro:IPR036257" /db_xref="InterPro:IPR036909" /db_xref="SubtiList:BG10215" /db_xref="UniProtKB/Swiss-Prot:P24011" /translation="MVKHWRLILLLALVPLLLSGCGKPFLSTLKPAGEVADKQYDLTV LSTLIMVVVVAVVSVIFFYVIVRFRRSRVGENTIPKQVEGNKFLEITWTVIPILLLII LVIPVVLYTLELADTSPMDKKGRKAEDALVVNVRANLYWWEFEYPDYGIITSQELIVP TDQRVYFNLKASDVKHSFWIPSVGGKLDTNTDNENKFFLTFDSKRSKEAGDMFFGKCA ELCGPSHALMDFKVKTMSAKEFQGWTKEMKNYKSTAESDLAKQGEELFKEKNCLSCHA VEPNDKRAEAARTAPNLATFGERTKVAGVKEANKENVKAWLKDPDSIKPGNKMTGTYP KLSDSETNALYEYLKGLKAESK*" /label="ctaC CDS" gene 1472794..1473864 /gene="ctaC" /locus_tag="BSU_14890" /old_locus_tag="BSU14890" /label="ctaC gene" CDS 1473897..1475765 /gene="ctaD" /locus_tag="BSU_14900" /old_locus_tag="BSU14900" /EC_number="1.9.3.1" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1685007, 1847686, 10675592, 15849754, 16850406, 27503613" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1685007, 1847686, 10675592, 15849754, 16850406, 27503613; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cytochrome caa3 oxidase (subunit I)" /protein_id="NP_389373.2" /db_xref="EnsemblGenomes-Gn:BSU14900" /db_xref="EnsemblGenomes-Tr:CAB13363" /db_xref="GOA:P24010" /db_xref="InterPro:IPR000883" /db_xref="InterPro:IPR014241" /db_xref="InterPro:IPR023615" /db_xref="InterPro:IPR023616" /db_xref="InterPro:IPR036927" /db_xref="SubtiList:BG10216" /db_xref="UniProtKB/Swiss-Prot:P24010" /translation="MLNALTEKRTRGSMLWDYLTTVDHKKIAILYLVAGGFFFLVGGI EAMFIRIQLAKPENAFLSAQAYNEVMTMHGTTMIFLAAMPLLFALMNAVVPLQIGARD VSFPFLNALGFWLFFFGGIFLNLSWFLGGAPDAGWTSYASLSLHSKGHGIDFFVLGLQ ISGLGTLIAGINFLATIINMRAPGMTYMRLPLFTWTTFVASALILFAFPPLTVGLALM MLDRLFGTNFFNPELGGNTVIWEHLFWIFGHPEVYILILPAFGIFSEVIPVFARKRLF GYSSMVFAIVLIGFLGFMVWVHHMFTTGLGPIANAIFAVATMAIAIPTGIKIFNWLLT IWGGNVKYTTAMLYAVSFIPSFVLGGVTGVMLAAAAADYQFHDTYFVVAHFHYVIIGG VVFGLLAGVHFWWPKMFGKILHETMGKISFVLFFIGFHLTFFIQHFVGLMGMPRRVYT FLPGQGLETGNLISTIGAFFMAAAVILLLVNVIWTSVKGEYVGADPWHDGRTLEWTVS SPPPEYNFKQLPFVRGLDPLWIEKQAGHKSMTPAEPVDDIHMPNGSILPLIISFGLFV AAFGLLYRSDYAWGLPVIFIGLGITFITMLLRSVIDDHGYHIHKEELPNDDKGVKA*" /label="ctaD CDS" gene 1473897..1475765 /gene="ctaD" /locus_tag="BSU_14900" /old_locus_tag="BSU14900" /label="ctaD gene" CDS 1475765..1476388 /gene="ctaE" /locus_tag="BSU_14910" /old_locus_tag="BSU14910" /EC_number="1.9.3.1" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1685007, 1847686, 10675592, 15849754, 16850406, 27503613" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1685007, 1847686, 10675592, 15849754, 16850406, 27503613; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cytochrome caa3 oxidase (subunit III)" /protein_id="NP_389374.1" /db_xref="EnsemblGenomes-Gn:BSU14910" /db_xref="EnsemblGenomes-Tr:CAB13364" /db_xref="GOA:P24012" /db_xref="InterPro:IPR000298" /db_xref="InterPro:IPR013833" /db_xref="InterPro:IPR024791" /db_xref="InterPro:IPR033946" /db_xref="InterPro:IPR035973" /db_xref="SubtiList:BG10217" /db_xref="UniProtKB/Swiss-Prot:P24012" /translation="MQVQEKFTAETFPASPEKVTLEGKNKFLGFWLFLGGETVLFASL FATFLALRNSNAGDPPTTEMFDVTLVFIATMLLLTSSLTSVYAMYHMKNFSFGKMQLW LGITILLGAGFLGLEIYEFKHYTHEFGFTITSSALGSAFYTLVGTHGAHVAFGLMWIS TLMIRNAKRGLNLYTAPKFYVASLYWHFIDVVWVFIFTVVYLMGMVG*" /label="ctaE CDS" gene 1475765..1476388 /gene="ctaE" /locus_tag="BSU_14910" /old_locus_tag="BSU14910" /label="ctaE gene" CDS 1476391..1476723 /gene="ctaF" /locus_tag="BSU_14920" /old_locus_tag="BSU14920" /EC_number="1.9.3.1" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1685007, 1847686, 10675592, 15849754, 16850406, 27503613" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1685007, 1847686, 10675592, 15849754, 16850406, 27503613; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cytochrome caa3 oxidase (subunit IV)" /protein_id="NP_389375.1" /db_xref="EnsemblGenomes-Gn:BSU14920" /db_xref="EnsemblGenomes-Tr:CAB13365" /db_xref="GOA:P24013" /db_xref="InterPro:IPR005171" /db_xref="InterPro:IPR014257" /db_xref="SubtiList:BG10218" /db_xref="UniProtKB/Swiss-Prot:P24013" /translation="MVDKKSRGHINSDLEFKKKKHAREMKYQVLSFGLMIGLTIVAFL TVATDGVGSWFTIPFIILLAAIQVIFQLYYFMHMNQKGHEAPALFLYSGVFVAFITVL AFVTIIWW*" /label="ctaF CDS" gene 1476391..1476723 /gene="ctaF" /locus_tag="BSU_14920" /old_locus_tag="BSU14920" /label="ctaF gene" CDS 1476750..1477643 /gene="ctaG" /locus_tag="BSU_14930" /old_locus_tag="BSU14930" /function="16.10: Respire" /function="16.13: Shape" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:14766920, 15849754, 16305244, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14766920, 15849754, 16305244, 16850406; Product type f: factor" /codon_start=1 /transl_table=11 /product="cytochrome aa(3) assembly factor" /protein_id="NP_389376.1" /db_xref="EnsemblGenomes-Gn:BSU14930" /db_xref="EnsemblGenomes-Tr:CAB13366" /db_xref="GOA:O34329" /db_xref="InterPro:IPR014108" /db_xref="InterPro:IPR019108" /db_xref="SubtiList:BG12579" /db_xref="UniProtKB/Swiss-Prot:O34329" /translation="MNQLEIFGFRAMWSPYLFCILLGITALYLYFYRRMSSKPNRITG KEMVCFLSAMLFLYAAEGSPVDLLGHIMFSAHMVQMAVLYLVVPPLLIAGIPAWLWEK IIFRPSIKPVFSFFTTPLIALLLFNGIFSLYHVPLIFDTVKTDPFYHTLITWLIFVLA FFMWWPLVHKVERLRQLSGLMKLGYIMADGMLLTPACALIMFSGAPLYATYTDPALWA EAMRLCVPADMMGQVPLTGPEMLNTLPLLEDQQLGAVMMKIIQEIVYGTFLAVIFFQW VKKEREKDGQEEPPYIQQTIS*" /label="ctaG CDS" gene 1476750..1477643 /gene="ctaG" /locus_tag="BSU_14930" /old_locus_tag="BSU14930" /label="ctaG gene" downshifts 1477618 /Source="Nicolas_upshifts" /id="D845" /incds=0 /nref=121 /ntot=229 /MaxReadThrough="1.94099" /MaxDrop="5.91271" /score="4.35633365" /energy="-13.3" /TU="NA" /idTUdmin="U1239" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1477675..1478037) /gene="ylbA" /locus_tag="BSU_14940" /old_locus_tag="BSU14940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389377.1" /db_xref="EnsemblGenomes-Gn:BSU14940" /db_xref="EnsemblGenomes-Tr:CAB13367" /db_xref="InterPro:IPR014967" /db_xref="InterPro:IPR036491" /db_xref="SubtiList:BG13353" /db_xref="UniProtKB/Swiss-Prot:O34743" /translation="MLKFTESGLEGVKAELSWLDDLMESKGLIRAGQWDYERVTYDKK FSTIEGTFYLRIQGIAAEGDVGSGRAVIQLMSPLLGKHYYPHGVEYGETEEFPVQVVT KSKALIQDIANMLKTVQM*" /label="ylbA CDS" gene complement(1477675..1478037) /gene="ylbA" /locus_tag="BSU_14940" /old_locus_tag="BSU14940" /label="ylbA gene" downshifts complement(1477694) /Source="Nicolas_upshifts" /id="D846" /incds=0 /nref=217 /ntot=257 /MaxReadThrough="1.00586" /MaxDrop="6.68145" /score="-3.42191479" /energy="-11.2" /TU="NA" /idTUdmin="U1244" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1478030..1478034 /Source="Nicolas_upshift_promotors" /id="U1243" /multdbtbs="SigF" /comp="M15" /sig="Sig-" /pcomp="0.57942057942058" /psig="0.367632367632368" /xcortree=1041 /SigmaFactorBS="cccttcaagtccgctttcagtaaacTTCAAcactgaccCCTC CTTATAAAAAttacctttcctgacaatcatagtatgaaagcgttaaactttcaatgaa t" /listShort="S545, ylbB, ylbC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1478043..1478056 /Source="Nicolas_upshift_promotors" /id="U1243" /multdbtbs="SigF" /comp="M15" /sig="Sig-" /pcomp="0.57942057942058" /psig="0.367632367632368" /xcortree=1041 /SigmaFactorBS="cccttcaagtccgctttcagtaaacTTCAAcactgaccCCTC CTTATAAAAAttacctttcctgacaatcatagtatgaaagcgttaaactttcaatgaa t" /listShort="S545, ylbB, ylbC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1478061..1478080) /Source="Nicolas_upshift_promotors" /id="U1244" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.78921078921079" /psig="0.985014985014985" /xcortree=515 /SigmaFactorBS="aatttttgcatactttcaaaagaagaagattCATTGAAAgtt taacgctttcaTACTATGATTGTCAGGAAAGgtaatttttataaggaggggtcagtgt t" /listShort="ylbA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1478065..1478176 /Source="Nicolas_S_feature" /locus_tag="new_1565737_1565848" /HighExp="S7, S8, S4, S3, S6, S5, T5.0H, T4.0H, BC, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.368" /TUlongSig="NA" /TUlongPSig="NA" /label="S545" upshifts 1478065 /Source="Nicolas_upshifts" /id="U1243" /multdbtbs="SigF" /comp="M15" /sig="Sig-" /pcomp="0.57942057942058" /psig="0.367632367632368" /xcortree=1041 /SigmaFactorBS="cccttcaagtccgctttcagtaaacTTCAAcactgaccCCTC CTTATAAAAAttacctttcctgacaatcatagtatgaaagcgttaaactttcaatgaa t" /listShort="S545, ylbB, ylbC" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1478073) /Source="Nicolas_upshifts" /id="U1244" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.78921078921079" /psig="0.985014985014985" /xcortree=515 /SigmaFactorBS="aatttttgcatactttcaaaagaagaagattCATTGAAAgtt taacgctttcaTACTATGATTGTCAGGAAAGgtaatttttataaggaggggtcagtgt t" /listShort="ylbA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1478095..1478102) /Source="Nicolas_upshift_promotors" /id="U1244" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.78921078921079" /psig="0.985014985014985" /xcortree=515 /SigmaFactorBS="aatttttgcatactttcaaaagaagaagattCATTGAAAgtt taacgctttcaTACTATGATTGTCAGGAAAGgtaatttttataaggaggggtcagtgt t" /listShort="ylbA" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1478177..1478623 /gene="ylbB" /locus_tag="BSU_14950" /old_locus_tag="BSU14950" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /function="18.1: Enzymes of unknown specificity" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_389378.2" /db_xref="EnsemblGenomes-Gn:BSU14950" /db_xref="EnsemblGenomes-Tr:CAB13368" /db_xref="InterPro:IPR000644" /db_xref="SubtiList:BG13354" /db_xref="UniProtKB/Swiss-Prot:O34682" /translation="MTKIKDLMTADLQYCTVLDNVYEAAVKMKDANVGAIPVVDEDGE TLVGIVTDRDLVLRGIAIKKPNSQKITDAMTEKPVSVEEDASVDEVLHLMASHQLRRI PVTKNKKLTGIVTLGDLSLSEQTNERAGSALSDISEGDNREEGFFH*" /label="ylbB CDS" gene 1478177..1478623 /gene="ylbB" /locus_tag="BSU_14950" /old_locus_tag="BSU14950" /label="ylbB gene" promotor_-35 1478209..1478216 /Source="Nicolas_upshift_promotors" /id="U1245" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.536463536463537" /psig="0.996003996003996" /xcortree=2165 /SigmaFactorBS="acggatgacaaaaataaaagatctgatgacagccgaCTTGCA ATattgcacggtaTTAGATAATGTATATGAAGCtgcagtaaagatgaaggacgcaaat g" /listShort="ylbC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1478228..1478247 /Source="Nicolas_upshift_promotors" /id="U1245" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.536463536463537" /psig="0.996003996003996" /xcortree=2165 /SigmaFactorBS="acggatgacaaaaataaaagatctgatgacagccgaCTTGCA ATattgcacggtaTTAGATAATGTATATGAAGCtgcagtaaagatgaaggacgcaaat g" /listShort="ylbC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1478233 /Source="Nicolas_upshifts" /id="U1245" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.536463536463537" /psig="0.996003996003996" /xcortree=2165 /SigmaFactorBS="acggatgacaaaaataaaagatctgatgacagccgaCTTGCA ATattgcacggtaTTAGATAATGTATATGAAGCtgcagtaaagatgaaggacgcaaat g" /listShort="ylbC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1478632..1478639 /Source="Nicolas_upshift_promotors" /id="U1246" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig="0.731268731268731" /xcortree=141 /SigmaFactorBS="aagaaggcttttttcattaacacataaaTCTTTGACatgtta aataggcTGTATTGTAATGGGATGTAAacaagagattgtgaatcgccacgggggtgat a" /listShort="ylbC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1478653..1478672 /Source="Nicolas_upshift_promotors" /id="U1246" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig="0.731268731268731" /xcortree=141 /SigmaFactorBS="aagaaggcttttttcattaacacataaaTCTTTGACatgtta aataggcTGTATTGTAATGGGATGTAAacaagagattgtgaatcgccacgggggtgat a" /listShort="ylbC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1478664 /Source="Nicolas_upshifts" /id="U1246" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.515484515484515" /psig="0.731268731268731" /xcortree=141 /SigmaFactorBS="aagaaggcttttttcattaacacataaaTCTTTGACatgtta aataggcTGTATTGTAATGGGATGTAAacaagagattgtgaatcgccacgggggtgat a" /listShort="ylbC" /GFF_Attribute="listLong" /label="upshifts" CDS 1478707..1479747 /gene="ylbC" /locus_tag="BSU_14960" /old_locus_tag="BSU14960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389379.1" /db_xref="EnsemblGenomes-Gn:BSU14960" /db_xref="EnsemblGenomes-Tr:CAB13369" /db_xref="GOA:O34586" /db_xref="InterPro:IPR014044" /db_xref="InterPro:IPR029410" /db_xref="InterPro:IPR035940" /db_xref="SubtiList:BG13355" /db_xref="UniProtKB/Swiss-Prot:O34586" /translation="MKNILRAMVILLIICGTYVLFIQYGSVPEKKSNDSEPQVSNEEA QSGKRIHMPTSGLLSFMGKHADEVTKKLGEPERIDPSAYDYDWWVYNQGKDQYIQIGV LNNKVVTLFASGNDINAKPFKIGESTGEVFKTTQVAPFVNVEYKGNSYRFEFSEEDIN TRPTVKVGKMYVQLYMDKFEGKLSSIRAFDAQTFVKQRPYEVVYRGELIKPKAVSDEK WKKIQTTSEKQILDLTNVIRVKHGLAKLEWDQPTAEVAFGHSEDMKENNYFSHVSKKY GSLKDRLEEGHVDFQQAGENIAYNYVDGPAAVEGWLNSEGHRKALLNSDYTHLGVGVD RKYYTQNFIKRW*" /label="ylbC CDS" gene 1478707..1479747 /gene="ylbC" /locus_tag="BSU_14960" /old_locus_tag="BSU14960" /label="ylbC gene" promotor_-10 complement(1479670..1479688) /Source="Nicolas_upshift_promotors" /id="U1247" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1068 /SigmaFactorBS="aataaagttttgggtgtaatatttccGGTCTActccgacacc aagatGCGTATAATCTGAATTCAGaagcgcttttcgatggccttcgctattcagccag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1479675) /Source="Nicolas_upshifts" /id="U1247" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1068 /SigmaFactorBS="aataaagttttgggtgtaatatttccGGTCTActccgacacc aagatGCGTATAATCTGAATTCAGaagcgcttttcgatggccttcgctattcagccag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1479704..1479709) /Source="Nicolas_upshift_promotors" /id="U1247" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1068 /SigmaFactorBS="aataaagttttgggtgtaatatttccGGTCTActccgacacc aagatGCGTATAATCTGAATTCAGaagcgcttttcgatggccttcgctattcagccag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1479727 /Source="Nicolas_upshifts" /id="D847" /incds=0 /nref=84 /ntot=252 /MaxReadThrough="1.59604" /MaxDrop="4.17709" /score="-1.16631837" /energy="-8.1" /TU="NA" /idTUdmin="U1243" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" promotor_-35 1479911..1479920 /Source="Nicolas_upshift_promotors" /id="U1248" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1306 /SigmaFactorBS="aaaattcatttgggaatgaatatAGGCGAACACaatgcccga caaaACGATACATTGTAGTAGGTAacgattttcggagggggtgaggattgtggcgaat c" /listShort="ylbD, ylbE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1479934..1479953 /Source="Nicolas_upshift_promotors" /id="U1248" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1306 /SigmaFactorBS="aaaattcatttgggaatgaatatAGGCGAACACaatgcccga caaaACGATACATTGTAGTAGGTAacgattttcggagggggtgaggattgtggcgaat c" /listShort="ylbD, ylbE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1479948 /Source="Nicolas_upshifts" /id="U1248" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1306 /SigmaFactorBS="aaaattcatttgggaatgaatatAGGCGAACACaatgcccga caaaACGATACATTGTAGTAGGTAacgattttcggagggggtgaggattgtggcgaat c" /listShort="ylbD, ylbE" /GFF_Attribute="listLong" /label="upshifts" CDS 1479979..1480377 /gene="ylbD" /locus_tag="BSU_14970" /old_locus_tag="BSU14970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 19775244, 22882546; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="sporulation-related protein (coat)" /protein_id="NP_389380.1" /db_xref="EnsemblGenomes-Gn:BSU14970" /db_xref="EnsemblGenomes-Tr:CAB13370" /db_xref="InterPro:IPR025953" /db_xref="SubtiList:BG13356" /db_xref="UniProtKB/Swiss-Prot:O34880" /translation="MANQHANHSINDFKQFVKKHPKLIKEVRKEQRSWQDVYENWVLF GESDPIWDPYREPEEASEAVPETPQKNDFVSKMVTAVKKMDVNQMNEQINKMSQSISS LQSLLNTFSGSGQKHSQPGSGQHPFSFRKD*" /label="ylbD CDS" gene 1479979..1480377 /gene="ylbD" /locus_tag="BSU_14970" /old_locus_tag="BSU14970" /label="ylbD gene" downshifts complement(1479983) /Source="Nicolas_upshifts" /id="D848" /incds=0 /nref=2 /ntot=11 /MaxReadThrough="2.37349" /MaxDrop="4.0378" /score="40.2648817" /energy="-14.3" /TU="NA" /idTUdmin="U1247" /TUdmin="-374" /isTUend="FALSE" /label="downshifts" CDS 1480393..1480632 /gene="ylbE" /locus_tag="BSU_14980" /old_locus_tag="BSU14980" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22882546" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389381.1" /db_xref="EnsemblGenomes-Gn:BSU14980" /db_xref="EnsemblGenomes-Tr:CAB13371" /db_xref="InterPro:IPR025613" /db_xref="SubtiList:BG13357" /db_xref="UniProtKB/Swiss-Prot:O34958" /translation="MRKEVQEYILANEERKRFIREQPIWYRRLSRKPDDLSSFQLEMM NFYEKTIPHRVNQFTNGIQMAQMMMQMFQAMRTKD*" /label="ylbE CDS" gene 1480393..1480632 /gene="ylbE" /locus_tag="BSU_14980" /old_locus_tag="BSU14980" /label="ylbE gene" downshifts 1480611 /Source="Nicolas_upshifts" /id="D849" /incds=0 /nref=3 /ntot=17 /MaxReadThrough="2.09257" /MaxDrop="4.65792" /score="-7.8200921" /energy="-5.1" /TU="NA" /idTUdmin="U1248" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1480699..1480706 /Source="Nicolas_upshift_promotors" /id="U1249" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=2169 /SigmaFactorBS="cggtcataaggttttgttggcggctgcggttaagcatTTTCC AATtggctggtttCATGGTAAACTAACAACTGGaggtgcatgttatgtatgcgacgat g" /listShort="ylbF, ylbG, NA, S548, S549, ylbH, coaD, S550, S552, ylbK, ylbL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1480717..1480736 /Source="Nicolas_upshift_promotors" /id="U1249" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=2169 /SigmaFactorBS="cggtcataaggttttgttggcggctgcggttaagcatTTTCC AATtggctggtttCATGGTAAACTAACAACTGGaggtgcatgttatgtatgcgacgat g" /listShort="ylbF, ylbG, NA, S548, S549, ylbH, coaD, S550, S552, ylbK, ylbL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1480722 /Source="Nicolas_upshifts" /id="U1249" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=2169 /SigmaFactorBS="cggtcataaggttttgttggcggctgcggttaagcatTTTCC AATtggctggtttCATGGTAAACTAACAACTGGaggtgcatgttatgtatgcgacgat g" /listShort="ylbF, ylbG, NA, S548, S549, ylbH, coaD, S550, S552, ylbK, ylbL" /GFF_Attribute="listLong" /label="upshifts" CDS 1480748..1481197 /gene="ricF" /locus_tag="BSU_14990" /old_locus_tag="BSU14990" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10712692, 15175311, 15661000, 23490197, 26434553, 27501195, 28295778" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10712692, 15175311, 15661000, 23490197, 26434553, 27501195, 28295778; Product type r: regulator" /codon_start=1 /transl_table=11 /product="subunit of a sporulation, competence and biofilmformation regulatory complex controlling RNase Y (RicAFTcomplex / FAD / two [4Fe-4S]2+)" /protein_id="NP_389382.1" /db_xref="EnsemblGenomes-Gn:BSU14990" /db_xref="EnsemblGenomes-Tr:CAB13372" /db_xref="GOA:O34412" /db_xref="InterPro:IPR010368" /db_xref="InterPro:IPR023378" /db_xref="SubtiList:BG13358" /db_xref="UniProtKB/Swiss-Prot:O34412" /translation="MYATMESVRLQSEAQQLAEMILQSETAENYRNCYKRLQEDEEAG RIIRSFIKIKEQYEDVQRFGKYHPDYREISRKMREIKRELDLNDKVADFKRAENELQS ILDEVSVEIGTAVSEHVKVPTGNPYFDGLSSCGGGCGSGGSCGCKVS*" /label="ricF CDS" gene 1480748..1481197 /gene="ricF" /locus_tag="BSU_14990" /old_locus_tag="BSU14990" /label="ricF gene" downshifts 1481183 /Source="Nicolas_upshifts" /id="D850" /incds=0 /nref=1 /ntot=6 /MaxReadThrough="5.95111" /MaxDrop="2.83" /score="-4.2014677" /energy="-11.5" /TU="U1249" /idTUdmin="U1248" /TUdmin=572 /isTUend="FALSE" /label="downshifts" CDS 1481252..1481524 /gene="ylbG" /locus_tag="BSU_15000" /old_locus_tag="BSU15000" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 10712692, 21532344, 22333191" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389383.1" /db_xref="EnsemblGenomes-Gn:BSU15000" /db_xref="EnsemblGenomes-Tr:CAB13373" /db_xref="GOA:O34658" /db_xref="InterPro:IPR016979" /db_xref="SubtiList:BG13359" /db_xref="UniProtKB/Swiss-Prot:O34658" /translation="MENRRQGMVVYLHSLKQSKMLRKFGNVHYVSKRLKYVVLYCDMD QIEKTMDKIASYSFVKKVEPSYKPFLKLEFESKLDKAKEYDYKIGI*" /label="ylbG CDS" gene 1481252..1481524 /gene="ylbG" /locus_tag="BSU_15000" /old_locus_tag="BSU15000" /label="ylbG gene" S_feature complement(1481329..1481552) /Source="Nicolas_S_feature" /locus_tag="new_1569001_1569224_c" /HighExp="S8, S7, S4, S5, S6, S3, C30, BT, G135, C90" /AntisenseName="ylbG" /AntisenseCor="-0.668594452827031" /AntisenseRegPval="-35.5" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.537" /TUlongSig="NA" /TUlongPSig="NA" /label="S546" misc_RNA 1481527..1481647 /gene="csfG" /locus_tag="BSU_misc_RNA_23" /product="sporulation-specific regulatory RNA" /experiment="publication(s) with functional evidences, PMID:21532344" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21532344; Product type n: RNA" /function="15.7: Sporulation and germination" /label="csfG RNA" gene 1481527..1481647 /gene="csfG" /locus_tag="BSU_misc_RNA_23" /label="csfG gene" S_feature complement(1481554..1481677) /Source="Nicolas_S_feature" /locus_tag="new_1569226_1569349_c" /HighExp="S3, S8, S7, G/S, S4, S5, Pyr, S6, B36, BT" /AntisenseName="NA" /AntisenseCor="-0.69279578575099399" /AntisenseRegPval="-39.1" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.537" /TUlongSig="NA" /TUlongPSig="NA" /label="S547" downshifts complement(1481597) /Source="Nicolas_upshifts" /id="D851" /incds=0 /nref=61 /ntot=131 /MaxReadThrough="3.9368" /MaxDrop="7.78892" /score="40.2648817" /energy="-14.3" /TU="U1250" /idTUdmin="U1250" /TUdmin="-228" /isTUend="FALSE" /label="downshifts" S_feature 1481648..1481753 /Source="Nicolas_S_feature" /locus_tag="new_1569320_1569425" /HighExp="H2O2, Paraq, Oxctl, G180, G135, G150, Cold, C30, Diami, Glucon" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S548" promotor_-10 complement(1481678..1481690) /Source="Nicolas_upshift_promotors" /id="U1250" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.537462537462537" /psig="0.537462537462537" /xcortree=1087 /SigmaFactorBS="ttccaaacaatgaacgctaatcttgataaacaggTGTATAGg cagcatgatccttGTCCATACTATAAgcaacagcatctagaggatgttgttgccaacc g" /listShort="S547, S546" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1481685) /Source="Nicolas_upshifts" /id="U1250" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.537462537462537" /psig="0.537462537462537" /xcortree=1087 /SigmaFactorBS="ttccaaacaatgaacgctaatcttgataaacaggTGTATAGg cagcatgatccttGTCCATACTATAAgcaacagcatctagaggatgttgttgccaacc g" /listShort="S547, S546" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1481705..1481711) /Source="Nicolas_upshift_promotors" /id="U1250" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.537462537462537" /psig="0.537462537462537" /xcortree=1087 /SigmaFactorBS="ttccaaacaatgaacgctaatcttgataaacaggTGTATAGg cagcatgatccttGTCCATACTATAAgcaacagcatctagaggatgttgttgccaacc g" /listShort="S547, S546" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1481734..1481738 /Source="Nicolas_upshift_promotors" /id="U1251" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.807192807192807" /psig=1 /xcortree=2460 /SigmaFactorBS="atcatgctgcctatacacctgtttatcaagattagcgttCAT TGtttggaagaatgcttTATGTTAAGATAGGATTGATttttttctatgtacatagcgg c" /listShort="S549, ylbH, coaD, S550" /listLong="S552, ylbK, ylbL" /label="promotor_-35" promotor_-10 1481754..1481773 /Source="Nicolas_upshift_promotors" /id="U1251" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.807192807192807" /psig=1 /xcortree=2460 /SigmaFactorBS="atcatgctgcctatacacctgtttatcaagattagcgttCAT TGtttggaagaatgcttTATGTTAAGATAGGATTGATttttttctatgtacatagcgg c" /listShort="S549, ylbH, coaD, S550" /listLong="S552, ylbK, ylbL" /label="promotor_-10" S_feature 1481755..1481846 /Source="Nicolas_S_feature" /locus_tag="new_1569427_1569518" /HighExp="H2O2, G135, Oxctl, Paraq, G180, dia0, G150, Lbexp, LBGexp, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S549" upshifts 1481755 /Source="Nicolas_upshifts" /id="U1251" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.807192807192807" /psig=1 /xcortree=2460 /SigmaFactorBS="atcatgctgcctatacacctgtttatcaagattagcgttCAT TGtttggaagaatgcttTATGTTAAGATAGGATTGATttttttctatgtacatagcgg c" /listShort="S549, ylbH, coaD, S550" /listLong="S552, ylbK, ylbL" /label="upshifts" CDS 1481847..1482401 /gene="rsmD" /locus_tag="BSU_15010" /old_locus_tag="BSU15010" /EC_number="2.1.1.171" /function="18.1: Enzymes of unknown specificity" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16014871, 17389639, 22535590, 22649054; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="16S rRNA m2G966 methyltransferase" /protein_id="NP_389384.2" /db_xref="EnsemblGenomes-Gn:BSU15010" /db_xref="EnsemblGenomes-Tr:CAB13374" /db_xref="GOA:O34331" /db_xref="InterPro:IPR004398" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG13360" /db_xref="UniProtKB/Swiss-Prot:O34331" /translation="MRVISGSKKGRSLKAVAGTSTRPTTDKVKESIFNMIGPYFDGGR GLDLFAGSGGLGIEALSRGFEHCIFVDRDFKAIQTVKSNLKTLELTKHAQVYRNDAER ALHAAAKRETGFRGIFLDPPYKEQKLKALLTLIDEYQMLEEDGFIVAEHDREVELPET VGDLVMTRKETYGLTGVAIYKKRG*" /label="rsmD CDS" gene 1481847..1482401 /gene="rsmD" /locus_tag="BSU_15010" /old_locus_tag="BSU15010" /label="rsmD gene" CDS 1482406..1482891 /gene="coaD" /locus_tag="BSU_15020" /old_locus_tag="BSU15020" /EC_number="2.7.7.3" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10480925, 10939241, 16014871, 21912874; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphopantetheine adenylyltransferase" /protein_id="NP_389385.1" /db_xref="EnsemblGenomes-Gn:BSU15020" /db_xref="EnsemblGenomes-Tr:CAB13375" /db_xref="GOA:O34797" /db_xref="InterPro:IPR001980" /db_xref="InterPro:IPR004821" /db_xref="InterPro:IPR014729" /db_xref="PDB:1O6B" /db_xref="SubtiList:BG13361" /db_xref="UniProtKB/Swiss-Prot:O34797" /translation="MASIAVCPGSFDPVTYGHLDIIKRGAHIFEQVYVCVLNNSSKKP LFSVEERCELLREVTKDIPNITVETSQGLLIDYAKRKNAKAILRGLRAVSDFEYEMQG TSVNRVLDESIETFFMMTNNQYSFLSSSIVKEVARYNGSVSEFVPPEVELALQQKFRQ G*" /label="coaD CDS" gene 1482406..1482891 /gene="coaD" /locus_tag="BSU_15020" /old_locus_tag="BSU15020" /label="coaD gene" downshifts 1482858 /Source="Nicolas_upshifts" /id="D852" /incds=0 /nref=26 /ntot=196 /MaxReadThrough="3.45558" /MaxDrop="3.85134" /score="13.7782945" /energy="-7.8" /TU="U1249,U1251" /idTUdmin="U1251" /TUdmin="-1296" /isTUend="FALSE" /label="downshifts" CDS complement(1482902..1484128) /gene="spoVV" /locus_tag="BSU_15030" /old_locus_tag="BSU15030" /function="16.5: Explore" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12662922, 15849754, 16850406, 28945739" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12662922, 15849754, 16850406, 28945739; Product type t: transporter" /codon_start=1 /transl_table=11 /product="dipicolinic acid transporter (to the spore)" /protein_id="NP_389386.1" /db_xref="EnsemblGenomes-Gn:BSU15030" /db_xref="EnsemblGenomes-Tr:CAB13376" /db_xref="GOA:O34765" /db_xref="InterPro:IPR011642" /db_xref="InterPro:IPR014226" /db_xref="SubtiList:BG13362" /db_xref="UniProtKB/Swiss-Prot:O34765" /translation="MNLSKINTLLIASFFLFLTATVISHPQASFEASKTGLSMWWEVV FPSLLPFFILSELLIGFGIVRFVGVLLEPFMRPIFRVPGVGGFVLAMGMASGNPAGAK LTARLRQENQISRVEAERLASFTNSSNPLFIFGAVAVGFFQNASLGILLASAHYLGNL AVGLTMRSYGRKEEQHLRRKKTIPFPSVKDALHALHTARLAEKRPLGKILGDAVTSSV QTLLMVGGFIILFSVFNRLLSVVQLTDVLSVFTKGALTLFQLPTQLDIPLLSGMFEIT LGSKLVSETDVSLLQKAIIVSFILGFSGFSVQAQVAGILSETDIRFKPFFIARLLQGV YAAVFVMLLWKPLYTAWHDPYQYVFKSLNSSDMSTAFINGWNLLVQIGPAVTLCALFT YIIIFSYRLTNGTKKG*" /label="spoVV CDS" gene complement(1482902..1484128) /gene="spoVV" /locus_tag="BSU_15030" /old_locus_tag="BSU15030" /label="spoVV gene" S_feature 1482903..1484177 /Source="Nicolas_S_feature" /locus_tag="new_1570575_1571849" /HighExp="H2O2, G135, Paraq, G150, G180, Oxctl, LBGexp, dia0, dia15, Mt0" /AntisenseName="ylbJ" /AntisenseCor="-0.54237424349391605" /AntisenseRegPval="-21.2" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S550" S_feature complement(1484129..1484230) /Source="Nicolas_S_feature" /locus_tag="new_1571801_1571902_c" /HighExp="LoTm, S3, S4, S5, T5.0H, M9-stat, T4.0H, S6, BT, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S551" promotor_-35 1484152..1484159 /Source="Nicolas_upshift_promotors" /id="U1252" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=1988 /SigmaFactorBS="acaagttcattcttacctccccgatgctaaaaaTGCCCAATg acatgtatatCATGATAAAATAATGTATGAtgtaaaacggccaagcagtacctgtcct c" /listShort="S552, ylbK, ylbL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1484171..1484190 /Source="Nicolas_upshift_promotors" /id="U1252" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=1988 /SigmaFactorBS="acaagttcattcttacctccccgatgctaaaaaTGCCCAATg acatgtatatCATGATAAAATAATGTATGAtgtaaaacggccaagcagtacctgtcct c" /listShort="S552, ylbK, ylbL" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1484179..1484308 /Source="Nicolas_S_feature" /locus_tag="new_1571851_1571980" /HighExp="Etha, dia15, dia5, Diami, H2O2, Lbtran, LBGtran, Paraq, G150, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S552" upshifts 1484179 /Source="Nicolas_upshifts" /id="U1252" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=1988 /SigmaFactorBS="acaagttcattcttacctccccgatgctaaaaaTGCCCAATg acatgtatatCATGATAAAATAATGTATGAtgtaaaacggccaagcagtacctgtcct c" /listShort="S552, ylbK, ylbL" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1484225..1484243) /Source="Nicolas_upshift_promotors" /id="U1253" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=985 /SigmaFactorBS="cctcctgcctgaattccctgtataccgaattctatGGTCTAa actgaacccctatgcTCGTATATTAGTACAAAGAatcaagaggacaggtactgcttgg c" /listShort="S551, ylbJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1484240) /Source="Nicolas_upshifts" /id="U1253" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=985 /SigmaFactorBS="cctcctgcctgaattccctgtataccgaattctatGGTCTAa actgaacccctatgcTCGTATATTAGTACAAAGAatcaagaggacaggtactgcttgg c" /listShort="S551, ylbJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1484260..1484265) /Source="Nicolas_upshift_promotors" /id="U1253" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=985 /SigmaFactorBS="cctcctgcctgaattccctgtataccgaattctatGGTCTAa actgaacccctatgcTCGTATATTAGTACAAAGAatcaagaggacaggtactgcttgg c" /listShort="S551, ylbJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1484309..1485091 /gene="ylbK" /locus_tag="BSU_15040" /old_locus_tag="BSU15040" /EC_number="3.1.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_389387.1" /db_xref="EnsemblGenomes-Gn:BSU15040" /db_xref="EnsemblGenomes-Tr:CAB13377" /db_xref="GOA:O34731" /db_xref="InterPro:IPR001423" /db_xref="InterPro:IPR002641" /db_xref="InterPro:IPR016035" /db_xref="SubtiList:BG13363" /db_xref="UniProtKB/Swiss-Prot:O34731" /translation="MAKPKIGLALGSGGARGLAHLGVLSSLHKHQIEVDMIAGSSMGA LVGSFYAAGHDVATMKKVAKAFKRRLYADYTVPKLGFLKGDRVRQLVHAYTFGKPIEE LQIPLGIVACDLQTGEKIVFRKGSVSDAVRASISIPGIFIPQRLDGRLLVDGAVVDRI PVSVVKDMGADIIIASDVSRVRKTETAVHIFDVIMQSMDILQNELVRHQTIAADIMIR PSLETYSSSSFANIEEMISAGEEATNRMISKIRKEIENWEGS*" /label="ylbK CDS" gene 1484309..1485091 /gene="ylbK" /locus_tag="BSU_15040" /old_locus_tag="BSU15040" /label="ylbK gene" promotor_-35 1484871..1484877 /Source="Nicolas_upshift_promotors" /id="U1254" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=814 /SigmaFactorBS="ttccagggttcgaaaaactgaaacagcagTGCATATttttga tgtgattATGCAAAGTATGgatatactgcaaaatgaattagtgcggcatcaaacaatt g" /listShort="ylbL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1484891..1484902 /Source="Nicolas_upshift_promotors" /id="U1254" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=814 /SigmaFactorBS="ttccagggttcgaaaaactgaaacagcagTGCATATttttga tgtgattATGCAAAGTATGgatatactgcaaaatgaattagtgcggcatcaaacaatt g" /listShort="ylbL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1484902 /Source="Nicolas_upshifts" /id="U1254" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=814 /SigmaFactorBS="ttccagggttcgaaaaactgaaacagcagTGCATATttttga tgtgattATGCAAAGTATGgatatactgcaaaatgaattagtgcggcatcaaacaatt g" /listShort="ylbL" /GFF_Attribute="listLong" /label="upshifts" CDS 1485093..1486118 /gene="ylbL" /locus_tag="BSU_15050" /old_locus_tag="BSU15050" /function="16.11: Scavenge (Catabolism)" /function="18.1: Enzymes of unknown specificity" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative degradative enzyme" /protein_id="NP_389388.2" /db_xref="EnsemblGenomes-Gn:BSU15050" /db_xref="EnsemblGenomes-Tr:CAB13378" /db_xref="GOA:O34470" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR008269" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR027065" /db_xref="InterPro:IPR036034" /db_xref="PDB:2KJP" /db_xref="SubtiList:BG13364" /db_xref="UniProtKB/Swiss-Prot:O34470" /translation="MLRKKHFSWMLVILILIAVLSFIKLPYYITKPGEATELASLIKV EGGYPEKGSLSLMTVKVGPANPFTYVWAKMHPYYEIVPDESIKEEGESDKEYMKRQLQ MMKSSQENAVIAAYQKAGKKVSYSFNGIYASSVVENMPAKGKIEVGDKIISADGKNYQ SAEKLIDYISSKKAGDKVTLKIEREEKEKRVTLTLKQFPDEPDRAGIGVSLYTDRNVK VEPDIDFEIENIGGPSAGLMMSLEIYNQLTKPDETKGYDIAGTGTIDVDGKVGPIGGI DQKVVAADKAGKDIFFAPNQNGASNSDYKNAVKTAKDIDSNMKIVPVDTMQDAIDYLN KLKAKST*" /label="ylbL CDS" gene 1485093..1486118 /gene="ylbL" /locus_tag="BSU_15050" /old_locus_tag="BSU15050" /label="ylbL gene" downshifts 1486002 /Source="Nicolas_upshifts" /id="D853" /incds=1 /nref=59 /ntot=235 /MaxReadThrough="2.38639" /MaxDrop="3.52503" /score="19.0874959" /energy="-11.5" /TU="NA" /idTUdmin="U1249" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1486135..1487382) /gene="ylbM" /locus_tag="BSU_15060" /old_locus_tag="BSU15060" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16014871, 19215769; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative component of the degradosome" /protein_id="NP_389389.1" /db_xref="EnsemblGenomes-Gn:BSU15060" /db_xref="EnsemblGenomes-Tr:CAB13379" /db_xref="InterPro:IPR008513" /db_xref="InterPro:IPR014729" /db_xref="SubtiList:BG13365" /db_xref="UniProtKB/Swiss-Prot:O34513" /translation="MKAVGLVVEYNPFHNGHLYHAQTAKLQTGCDTAVAVMSGHFLQR GEPAVVSKWARTKMALQSGVDLVIELPYLYAVQKADIFARGSVSILNELECEALFFGS ENGDIKPFLETAQLIDEHKHILNDRIKEELKKGASYPAAAAIAFSSILHTESALDLSK PNNILGYQYVTSILTGGYPMKPYTTARISSDYHDADLPEGENHIASATSIRKAMIGQN LEACLRFLPAASARELAAYRKSFGLWHTPESYFSYLKYSLSTVTARELQQVYEVEEGL EHRIIRSIRKSSSYQEFMELLKTKRYTWTRLQRMNTHILTRTKKQDMQKLLDNDKAPY IRLLGMTKKGQAYLSEKKKALSVPLVSKLSSFSHPALDLDVKASRIYSLPIEEPLRTE FDLQEYGHAPIRYDEDEQHFLNV*" /label="ylbM CDS" gene complement(1486135..1487382) /gene="ylbM" /locus_tag="BSU_15060" /old_locus_tag="BSU15060" /label="ylbM gene" downshifts complement(1486162) /Source="Nicolas_upshifts" /id="D854" /incds=0 /nref=8 /ntot=182 /MaxReadThrough="1.58661" /MaxDrop="3.70777" /score="4.49214865" /energy="-11.5" /TU="NA" /idTUdmin="U1257" /TUdmin=775 /isTUend="FALSE" /label="downshifts" promotor_-35 1487299..1487305 /Source="Nicolas_upshift_promotors" /id="U1255" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=892 /SigmaFactorBS="atgtccgctcatgaccgcgacagccgtgtcacatccGGTTTG CagctttgctgtttGGGCATGATAAAggtgaccgttatgaaagggattatattcaacc a" /listShort="S553, ylbN" /listLong="rpmF" /label="promotor_-35" promotor_-10 1487319..1487330 /Source="Nicolas_upshift_promotors" /id="U1255" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=892 /SigmaFactorBS="atgtccgctcatgaccgcgacagccgtgtcacatccGGTTTG CagctttgctgtttGGGCATGATAAAggtgaccgttatgaaagggattatattcaacc a" /listShort="S553, ylbN" /listLong="rpmF" /label="promotor_-10" upshifts 1487323 /Source="Nicolas_upshifts" /id="U1255" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=892 /SigmaFactorBS="atgtccgctcatgaccgcgacagccgtgtcacatccGGTTTG CagctttgctgtttGGGCATGATAAAggtgaccgttatgaaagggattatattcaacc a" /listShort="S553, ylbN" /listLong="rpmF" /label="upshifts" CDS complement(1487379..1487564) /gene="ylzH" /locus_tag="BSU_15069" /old_locus_tag="BSU15069" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein,of unknown function" /protein_id="YP_003097727.1" /db_xref="EnsemblGenomes-Gn:BSU15069" /db_xref="EnsemblGenomes-Tr:CAX52618" /db_xref="UniProtKB/Swiss-Prot:C0H411" /translation="MIIAFKIVFVNIFSLQHNAAIEVSLTAEYAMHTLKTKIRRKSFH LQMYHTFLNIARKAEKI*" /label="ylzH CDS" gene complement(1487379..1487564) /gene="ylzH" /locus_tag="BSU_15069" /old_locus_tag="BSU15069" /label="ylzH gene" promotor_-35 1487397..1487401 /Source="Nicolas_upshift_promotors" /id="U1256" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.872127872127872" /psig=1 /xcortree=2505 /SigmaFactorBS="aatccgacagctttcatattttttccgccttTCTTGctatgt ttaaaaacgTATGGTACATTTGCAAATGAaaactcttacgccttatttttgttttaag t" /listShort="S553, ylbN, rpmF" /listLong="ylbO" /label="promotor_-35" promotor_-10 1487417..1487436 /Source="Nicolas_upshift_promotors" /id="U1256" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.872127872127872" /psig=1 /xcortree=2505 /SigmaFactorBS="aatccgacagctttcatattttttccgccttTCTTGctatgt ttaaaaacgTATGGTACATTTGCAAATGAaaactcttacgccttatttttgttttaag t" /listShort="S553, ylbN, rpmF" /listLong="ylbO" /label="promotor_-10" S_feature 1487426..1487561 /Source="Nicolas_S_feature" /locus_tag="new_1575098_1575233" /HighExp="Cold, LoTm, Diami, Paraq, H2O2, Oxctl, G180, dia5, G135, LBGexp" /AntisenseName="ylzH" /AntisenseCor="-9.1134498265910996E-2" /AntisenseRegPval="-0.9" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF" /TUshortPSig="1, 0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S553" upshifts 1487426 /Source="Nicolas_upshifts" /id="U1256" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.872127872127872" /psig=1 /xcortree=2505 /SigmaFactorBS="aatccgacagctttcatattttttccgccttTCTTGctatgt ttaaaaacgTATGGTACATTTGCAAATGAaaactcttacgccttatttttgttttaag t" /listShort="S553, ylbN, rpmF" /listLong="ylbO" /label="upshifts" promotor_-10 complement(1487455..1487474) /Source="Nicolas_upshift_promotors" /id="U1257" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.502497502497502" /psig="0.988011988011988" /xcortree=2270 /SigmaFactorBS="tctttacagcataatgctgccattgaagtaTCGTTGACagcg gaatatgctATGCATACACTTAAAACAAAaataaggcgtaagagttttcatttgcaaa t" /listShort="ylbM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1487465) /Source="Nicolas_upshifts" /id="U1257" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.502497502497502" /psig="0.988011988011988" /xcortree=2270 /SigmaFactorBS="tctttacagcataatgctgccattgaagtaTCGTTGACagcg gaatatgctATGCATACACTTAAAACAAAaataaggcgtaagagttttcatttgcaaa t" /listShort="ylbM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1487488..1487495) /Source="Nicolas_upshift_promotors" /id="U1257" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.502497502497502" /psig="0.988011988011988" /xcortree=2270 /SigmaFactorBS="tctttacagcataatgctgccattgaagtaTCGTTGACagcg gaatatgctATGCATACACTTAAAACAAAaataaggcgtaagagttttcatttgcaaa t" /listShort="ylbM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1487532..1487539 /Source="Nicolas_upshift_promotors" /id="U1258" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=2657 /SigmaFactorBS="atggcagcattatgctgtaaagaaaaaatATTGACAAaaaca atcttaaaAGCTATAATCATGTTTGTTGctttcctgaggtgatacaaatgaaatggac g" /listShort="ylbN, rpmF, ylbO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1487553..1487572 /Source="Nicolas_upshift_promotors" /id="U1258" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=2657 /SigmaFactorBS="atggcagcattatgctgtaaagaaaaaatATTGACAAaaaca atcttaaaAGCTATAATCATGTTTGTTGctttcctgaggtgatacaaatgaaatggac g" /listShort="ylbN, rpmF, ylbO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1487563 /Source="Nicolas_upshifts" /id="U1258" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=2657 /SigmaFactorBS="atggcagcattatgctgtaaagaaaaaatATTGACAAaaaca atcttaaaAGCTATAATCATGTTTGTTGctttcctgaggtgatacaaatgaaatggac g" /listShort="ylbN, rpmF, ylbO" /GFF_Attribute="listLong" /label="upshifts" CDS 1487592..1488110 /gene="ylbN" /locus_tag="BSU_15070" /old_locus_tag="BSU15070" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11700356, 22720735" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389390.1" /db_xref="EnsemblGenomes-Gn:BSU15070" /db_xref="EnsemblGenomes-Tr:CAB13380" /db_xref="InterPro:IPR003772" /db_xref="SubtiList:BG13366" /db_xref="UniProtKB/Swiss-Prot:O34445" /translation="MKWTIYQLHQMPKQSFEFDETVELNELTKLNSDIRRISPVRVKG RADIKSKQVSFDFTISGEMLLPCSRTLVDVPYPFEISTKELFIFHHTDDIEDDDVHIV EDDTIDITPIVKEEILLEIPMQIFCESEQEKGAAPQEGKDWQVISEEDKKNQVDPRLA ALEKLLKQDDES*" /label="ylbN CDS" gene 1487592..1488110 /gene="ylbN" /locus_tag="BSU_15070" /old_locus_tag="BSU15070" /label="ylbN gene" CDS 1488132..1488311 /gene="rpmF" /locus_tag="BSU_15080" /old_locus_tag="BSU15080" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299; Product type f : factor" /codon_start=1 /transl_table=11 /product="ribosomal protein L32" /protein_id="NP_389391.1" /db_xref="EnsemblGenomes-Gn:BSU15080" /db_xref="EnsemblGenomes-Tr:CAB13381" /db_xref="GOA:O34687" /db_xref="InterPro:IPR002677" /db_xref="InterPro:IPR011332" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG12668" /db_xref="UniProtKB/Swiss-Prot:O34687" /translation="MAVPFRRTSKMKKRLRRTHFKLNVPGMTECPSCGEMKLSHRVCK ACGSYNGKDINVKSN*" /label="rpmF CDS" gene 1488132..1488311 /gene="rpmF" /locus_tag="BSU_15080" /old_locus_tag="BSU15080" /label="rpmF gene" downshifts 1488291 /Source="Nicolas_upshifts" /id="D855" /incds=0 /nref=232 /ntot=266 /MaxReadThrough="5.64002" /MaxDrop="7.70407" /score="53.0065581" /energy="-17.1" /TU="U1258" /idTUdmin="U1256" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts complement(1488334) /Source="Nicolas_upshifts" /id="U1259" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.946053946053946" /psig=0 /xcortree=65 /SigmaFactorBS="actatttgcactcacaaattttccgcaagctgacaggaagag aaaaagaaaaaGCGCagggctttcaccctgcgcttttctcattagttactttttacat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(1488338..1488341) /Source="Nicolas_upshift_promotors" /id="U1259" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.946053946053946" /psig=0 /xcortree=65 /SigmaFactorBS="actatttgcactcacaaattttccgcaagctgacaggaagag aaaaagaaaaaGCGCagggctttcaccctgcgcttttctcattagttactttttacat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-35 1488392..1488397 /Source="Nicolas_upshift_promotors" /id="U1260" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1162 /SigmaFactorBS="tcttcctgtcagcttgcggaaaatttgtgagtgcaaatAGTC TAtctaatctattaccgGCATATGTATGAGATAAATaagctgacatggagggagattg a" /listShort="ylbO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1488413..1488431 /Source="Nicolas_upshift_promotors" /id="U1260" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1162 /SigmaFactorBS="tcttcctgtcagcttgcggaaaatttgtgagtgcaaatAGTC TAtctaatctattaccgGCATATGTATGAGATAAATaagctgacatggagggagattg a" /listShort="ylbO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1488414 /Source="Nicolas_upshifts" /id="U1260" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1162 /SigmaFactorBS="tcttcctgtcagcttgcggaaaatttgtgagtgcaaatAGTC TAtctaatctattaccgGCATATGTATGAGATAAATaagctgacatggagggagattg a" /listShort="ylbO" /GFF_Attribute="listLong" /label="upshifts" CDS 1488457..1489038 /gene="gerR" /locus_tag="BSU_15090" /old_locus_tag="BSU15090" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15621419, 20435725" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15621419, 20435725; Product type r: regulator" /codon_start=1 /transl_table=11 /product="DNA-binding regulator" /protein_id="NP_389392.1" /db_xref="EnsemblGenomes-Gn:BSU15090" /db_xref="EnsemblGenomes-Tr:CAB13382" /db_xref="GOA:O34549" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR014243" /db_xref="InterPro:IPR017930" /db_xref="SubtiList:BG13367" /db_xref="UniProtKB/Swiss-Prot:O34549" /translation="MTITRQDAWTQDEDLLLAEVVLRHIREGGTQLSAFEEVGRALTR TAAACGFRWNSYVRKQYQSGIELAKKQRKELRKQIGVHSVNMPNSMKQTASASSEGKR DLSIQDVIQFLEQFKETPSAQEFQLEREKLKEQIQSLQKELEDLRSENQTLRNQLEMT EEDYKALIDIMDRARKMVVSKEDGRMKKAAQET*" /label="gerR CDS" gene 1488457..1489038 /gene="gerR" /locus_tag="BSU_15090" /old_locus_tag="BSU15090" /label="gerR gene" downshifts 1489039 /Source="Nicolas_upshifts" /id="D856" /incds=0 /nref=56 /ntot=139 /MaxReadThrough="2.70626" /MaxDrop="5.6861" /score="-7.71867756" /energy="-12.8" /TU="U1260" /idTUdmin="U1258" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1489095..1489577) /gene="ylbP" /locus_tag="BSU_15100" /old_locus_tag="BSU15100" /EC_number="2.3.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_389393.2" /db_xref="EnsemblGenomes-Gn:BSU15100" /db_xref="EnsemblGenomes-Tr:CAB13383" /db_xref="GOA:O34468" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR017274" /db_xref="PDB:2PR1" /db_xref="SubtiList:BG13368" /db_xref="UniProtKB/Swiss-Prot:O34468" /translation="MTKVERLLINYKTLEEFKKFKEYGIQELSMLEELQDNIIENDST SPFYGIYFGDKLVARMSLYQVNGKSNPYFDNRQDYLELWKLEVLPGYQNRGYGRALVE FAKSFKMPIRTNPRMKSAEFWNKMNFKTVKYDMARDKGENPLIWHPDMDREMTPGESA *" /label="ylbP CDS" gene complement(1489095..1489577) /gene="ylbP" /locus_tag="BSU_15100" /old_locus_tag="BSU15100" /label="ylbP gene" downshifts complement(1489114) /Source="Nicolas_upshifts" /id="D857" /incds=0 /nref=90 /ntot=231 /MaxReadThrough="3.90092" /MaxDrop="6.59996" /score="14.5482917" /energy="-14.5" /TU="U1261" /idTUdmin="U1261" /TUdmin="-615" /isTUend="FALSE" /label="downshifts" downshifts 1489567 /Source="Nicolas_upshifts" /id="D858" /incds=0 /nref=1 /ntot=24 /MaxReadThrough="3.3013" /MaxDrop="4.42908" /score="-7.71867756" /energy="-12.8" /TU="NA" /idTUdmin="U1260" /TUdmin=418 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1489600..1489619) /Source="Nicolas_upshift_promotors" /id="U1261" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig=1 /xcortree=358 /SigmaFactorBS="cttctcaaagatcccatgtgcttaaaattaaagtttaaaTAT TTGGAttttttaaataaaGCGTTTACAATATATGTAGAaacaacaaagggggagattt g" /listShort="ylbP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1489619) /Source="Nicolas_upshifts" /id="U1261" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig=1 /xcortree=358 /SigmaFactorBS="cttctcaaagatcccatgtgcttaaaattaaagtttaaaTAT TTGGAttttttaaataaaGCGTTTACAATATATGTAGAaacaacaaagggggagattt g" /listShort="ylbP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1489633..1489640) /Source="Nicolas_upshift_promotors" /id="U1261" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig=1 /xcortree=358 /SigmaFactorBS="cttctcaaagatcccatgtgcttaaaattaaagtttaaaTAT TTGGAttttttaaataaaGCGTTTACAATATATGTAGAaacaacaaagggggagattt g" /listShort="ylbP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1489677..1489683 /Source="Nicolas_upshift_promotors" /id="U1262" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.826173826173826" /psig=1 /xcortree=1857 /SigmaFactorBS="aatatttaaactttaattttaagcacatgggatctttgagAA GTAATttcttcttactTCTGCTATGATAATACGTAAatgctaaattgggtgtgacatc a" /listShort="ylbQ, yllA" /listLong="S554, mraZ, mraW, ftsL, pbpB" /label="promotor_-35" promotor_-10 1489695..1489714 /Source="Nicolas_upshift_promotors" /id="U1262" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.826173826173826" /psig=1 /xcortree=1857 /SigmaFactorBS="aatatttaaactttaattttaagcacatgggatctttgagAA GTAATttcttcttactTCTGCTATGATAATACGTAAatgctaaattgggtgtgacatc a" /listShort="ylbQ, yllA" /listLong="S554, mraZ, mraW, ftsL, pbpB" /label="promotor_-10" upshifts 1489697 /Source="Nicolas_upshifts" /id="U1262" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.826173826173826" /psig=1 /xcortree=1857 /SigmaFactorBS="aatatttaaactttaattttaagcacatgggatctttgagAA GTAATttcttcttactTCTGCTATGATAATACGTAAatgctaaattgggtgtgacatc a" /listShort="ylbQ, yllA" /listLong="S554, mraZ, mraW, ftsL, pbpB" /label="upshifts" CDS 1489737..1490633 /gene="panE" /locus_tag="BSU_15110" /old_locus_tag="BSU15110" /EC_number="1.1.1.169" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1844812, 10736170, 23894131" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1844812, 10736170, 23894131; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-dehydropantoate 2-reductase" /protein_id="NP_389394.1" /db_xref="EnsemblGenomes-Gn:BSU15110" /db_xref="EnsemblGenomes-Tr:CAB13384" /db_xref="GOA:O34661" /db_xref="InterPro:IPR003710" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR013332" /db_xref="InterPro:IPR013752" /db_xref="InterPro:IPR036291" /db_xref="PDB:3EGO" /db_xref="SubtiList:BG13369" /db_xref="UniProtKB/Swiss-Prot:O34661" /translation="MKIGIIGGGSVGLLCAYYLSLYHDVTVVTRRQEQAAAIQSEGIR LYKGGEEFRADCSADTSINSDFDLLVVTVKQHQLQSVFSSLERIGKTNILFLQNGMGH IHDLKDWHVGHSIYVGIVEHGAVRKSDTAVDHTGLGAIKWSAFDDAEPDRLNILFQHN HSDFPIYYETDWYRLLTGKLIVNACINPLTALLQVKNGELLTTPAYLAFMKLVFQEAC RILKLENEEKAWERVQAVCGQTKENRSSMLVDVIGGRQTEADAIIGYLLKEASLQGLD AVHLEFLYGSIKALERNTNKVF*" /label="panE CDS" gene 1489737..1490633 /gene="panE" /locus_tag="BSU_15110" /old_locus_tag="BSU15110" /label="panE gene" CDS 1490704..1492323 /gene="bshC" /locus_tag="BSU_15120" /old_locus_tag="BSU15120" /EC_number="6.-.-.-" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16169927, 19578333, 20308541, 20799687, 25496067" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16169927, 19578333, 20308541, 20799687, 25496067; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="malate glucosamine cysteine ligase" /protein_id="NP_389395.2" /db_xref="EnsemblGenomes-Gn:BSU15120" /db_xref="EnsemblGenomes-Tr:CAB13385" /db_xref="GOA:P55342" /db_xref="InterPro:IPR011199" /db_xref="PDB:4WBD" /db_xref="SubtiList:BG11424" /db_xref="UniProtKB/Swiss-Prot:P55342" /translation="MQLTELSIKNQNVFVQHYIDGKEEMSSFFDYSIHHKDMWRERLE DLSSRFFAREELAAYLTSYHNKFGSSAMQSAIEKLKDPSSAAVVGGQQAGLLTGPLYT IHKIISIIVLAKQQEKELQVPVIPIFWVAGEDHDLDEINFVHTSEENGPVKKKLPQSY WKKSSAASTSLDQEKCAAWIDDVFAAFEETDHTNTLLDNVKRCLRESVTFTDFFELLI ADLFQEEGLVLLNSGDPGIKKLETAMFQKILRENDELARAVSDQQAFMRQAGYKPIIE SGKEQANLFYEYEDERFLIEKDNGRFVIKELDLGWTRDELHTHMEEHPERFSNNVVTR PLMQEFLIPTLAFIAGPGEINYWGELKQAFAVMGFKMPPVMPRLNITILERHIEKKLA ERNISLQDAIERGTENQRETYFERQIPEEFTAVMDQAKSQIEAIHKTVRQEALKVDQS LEPLLLKNAAFIQDQLQFLERTVMKRIEEKEGYVLKDYERIQNSIKPLLAPQERIWNI MYYLNRYGPKFFTTFKNLPFSFQNQHQVVKL*" /label="bshC CDS" gene 1490704..1492323 /gene="bshC" /locus_tag="BSU_15120" /old_locus_tag="BSU15120" /label="bshC gene" downshifts 1492295 /Source="Nicolas_upshifts" /id="D859" /incds=0 /nref=1 /ntot=16 /MaxReadThrough="3.87099" /MaxDrop="3.76832" /score="34.9463932" /energy="-8.3" /TU="U1262" /idTUdmin="U1262" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" promotor_-35 1492357..1492360 /Source="Nicolas_upshift_promotors" /id="U1263" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.501498501498502" /psig="0.955044955044955" /xcortree=3206 /SigmaFactorBS="aaactttgaaataaagttttaaagaaccctgactagttcagg GTTTttttttatgggtaaACAGTGTAAAATGAAGTTGTggagcgaagtggtgaatagt g" /listShort="S554, mraZ, mraW, ftsL, pbpB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1492375..1492448 /Source="Nicolas_S_feature" /locus_tag="new_1580047_1580120" /HighExp="M9-stat, T5.0H, T3.0H, Lbstat, Lbtran, T2.30H, T1.30H, M0t90, T1.0H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.955" /TUlongSig="SigA" /TUlongPSig=1 /label="S554" promotor_-10 1492375..1492394 /Source="Nicolas_upshift_promotors" /id="U1263" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.501498501498502" /psig="0.955044955044955" /xcortree=3206 /SigmaFactorBS="aaactttgaaataaagttttaaagaaccctgactagttcagg GTTTttttttatgggtaaACAGTGTAAAATGAAGTTGTggagcgaagtggtgaatagt g" /listShort="S554, mraZ, mraW, ftsL, pbpB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1492375 /Source="Nicolas_upshifts" /id="U1263" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.501498501498502" /psig="0.955044955044955" /xcortree=3206 /SigmaFactorBS="aaactttgaaataaagttttaaagaaccctgactagttcagg GTTTttttttatgggtaaACAGTGTAAAATGAAGTTGTggagcgaagtggtgaatagt g" /listShort="S554, mraZ, mraW, ftsL, pbpB" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(1492432) /Source="Nicolas_upshifts" /id="D860" /incds=0 /nref=17 /ntot=137 /MaxReadThrough="3.30554" /MaxDrop="4.47473" /score="-9.92306593" /energy="-12" /TU="NA" /idTUdmin="U1264" /TUdmin=1149 /isTUend="FALSE" /label="downshifts" CDS 1492449..1492880 /gene="mraZ" /locus_tag="BSU_15130" /old_locus_tag="BSU15130" /function="16.13: Shape" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10572301, 15939023, 16511046, 24659771, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="inhibitor of RsmH and transcriptional regulator" /protein_id="NP_389396.1" /db_xref="EnsemblGenomes-Gn:BSU15130" /db_xref="EnsemblGenomes-Tr:CAB13386" /db_xref="GOA:P55343" /db_xref="InterPro:IPR003444" /db_xref="InterPro:IPR007159" /db_xref="InterPro:IPR020603" /db_xref="InterPro:IPR035642" /db_xref="InterPro:IPR035644" /db_xref="SubtiList:BG11425" /db_xref="UniProtKB/Swiss-Prot:P55343" /translation="MFMGEYQHTIDAKGRMIVPAKFREGLGEQFVLTRGLDQCLFGYP MHEWKQIEEKLKALPLTKKDARAFTRFFFSGATECELDKQGRVNIASSLLNYAKLEKE CVVIGVSNRIELWSKVIWEQYTEEQEDSFAEIAENMIGFDI*" /label="mraZ CDS" gene 1492449..1492880 /gene="mraZ" /locus_tag="BSU_15130" /old_locus_tag="BSU15130" /label="mraZ gene" CDS 1492950..1493885 /gene="rsmH" /locus_tag="BSU_15140" /old_locus_tag="BSU15140" /EC_number="2.1.1.199" /function="16.6: Maintain" /function="16.13: Shape" /function="16.9: Replicate" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9294438, 9721276, 10572301, 16849811, 19965768, 20924196, 22561317, 27711192; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="16S rRNA m4C1402 methyltransferase" /protein_id="NP_389397.1" /db_xref="EnsemblGenomes-Gn:BSU15140" /db_xref="EnsemblGenomes-Tr:CAB13387" /db_xref="GOA:Q07876" /db_xref="InterPro:IPR002903" /db_xref="InterPro:IPR023397" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG10219" /db_xref="UniProtKB/Swiss-Prot:Q07876" /translation="MFQHKTVLLRETVDGLNIKPDGTYVDCTLGGAGHSTYLLQQLSE KGRLIAFDQDDTALQHAKEVLSDYKGQLILIKSNFRYLKEYLNEQGVTEVDGILFDLG VSSPQLDTPERGFSYHHDAPLDMRMDQSATLSAKEVVNEWRYEDLVRIFFKYGEEKFS KQIARKIEEARMKSPIQTTGQLVDLIKDAIPAPARRSGGHPAKRVFQAIRIAVNDELR VFEEALEQAIEVLKPGGRVSVITFHSLEDRICKTTFKEKSSLPELPPGLPVIPEEFEP ELKLITRKPITASQEELEENNRARSAKLRIAEKRK*" /label="rsmH CDS" gene 1492950..1493885 /gene="rsmH" /locus_tag="BSU_15140" /old_locus_tag="BSU15140" /label="rsmH gene" S_feature complement(1493552..1495004) /Source="Nicolas_S_feature" /locus_tag="new_1581224_1582676_c" /HighExp="Salt, Sw, B60, Etha, M9-stat, Gly, C30, LPhT, BC, B36" /AntisenseName="ftsL" /AntisenseCor="-0.195961042435877" /AntisenseRegPval="-2.9" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S555" CDS 1493925..1494278 /gene="ftsL" /locus_tag="BSU_15150" /old_locus_tag="BSU15150" /function="16.3: Control" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10792716, 10844672, 11994149, 16549676, 16936019, 17020588, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10792716, 10844672, 11994149, 16549676, 16936019, 17020588, 22720735; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="cell-division protein" /protein_id="NP_389398.1" /db_xref="EnsemblGenomes-Gn:BSU15150" /db_xref="EnsemblGenomes-Tr:CAB13388" /db_xref="GOA:Q07867" /db_xref="InterPro:IPR011922" /db_xref="SubtiList:BG10220" /db_xref="UniProtKB/Swiss-Prot:Q07867" /translation="MSNLAYQPEKQQRHAISPEKKVIVKKRASITLGEKVLLVLFAAA VLSVSLLIVSKAYAAYQTNIEVQKLEEQISSENKQIGDLEKSVADLSKPQRIMDIAKK NGLNLKDKKVKNIQE*" /label="ftsL CDS" gene 1493925..1494278 /gene="ftsL" /locus_tag="BSU_15150" /old_locus_tag="BSU15150" /label="ftsL gene" CDS 1494275..1496425 /gene="pbpB" /locus_tag="BSU_15160" /old_locus_tag="BSU15160" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:8636036, 10411726, 12682299, 14731276" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8636036, 10411726, 12682299, 14731276; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="penicillin-binding protein 2B" /protein_id="NP_389399.2" /db_xref="EnsemblGenomes-Gn:BSU15160" /db_xref="EnsemblGenomes-Tr:CAB13389" /db_xref="GOA:Q07868" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR005311" /db_xref="InterPro:IPR005543" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR036138" /db_xref="SubtiList:BG10221" /db_xref="UniProtKB/Swiss-Prot:Q07868" /translation="MIQMPKKNKFMNRGAAILSICFALFFFVILGRMAYIQITGKANG EVLATKATEQHEKKRTIEASRGSILDRKGKVIAEDTATYKLIAILDKKMTTDVKHPQH VVNKEKTAEALSKVINLDKADILDILNKDAKQVEFGSAGRDITYSQKQKIEKMKLPGI SFLRDTKRYYPNGVFASNLIGYAEVDEETNEISGAMGLEKVLDKYLKERDGYVTYESD KSGWELPNSKNKITAPKNGDNVYLTIDQKIQTFLEDSMTKVAQKYNPKKIMAAVVDPK TGKVLAMGQRPSFDPNKRDVTNYYNDLISYAYEPGSTMKIFTLAAAMQENVFNANEKY KSGTFEVGGAPVKDHNNGVGWGPTTYHDGVLRSSNVAFAKLAKEKLGYDRLNQYLHKF NFYQKTGIDLPGEVSSKINFKYEFDKASTAYGQASAVTPIQQIQAATAIANDGKMMKP YVIDHIVDPDKDKTIYQNKPESAGTPISASTAKKVRDILGEVVTSKIGTGQAYKIEGF DVAGKTGTAQIAGKGGYLDGTDNYIFSFMGMAPKDDPELLIYVAVQQPQLKAGQSSSD PVSEIFNPTMKNSLHYLNIEPTEKSDSDKEETKAQTMPDLTDQTVAAAQKKAKEENLT PIVIGSDVAVKEQYPKADEEVLTNQKVFLKTGGKIKMPDMTGWSRREVLQYGELAGIH IEVSGQGYAVSQSVKKDKEIKDKTVIKVKFKNPD*" /label="pbpB CDS" gene 1494275..1496425 /gene="pbpB" /locus_tag="BSU_15160" /old_locus_tag="BSU15160" /label="pbpB gene" promotor_-10 complement(1494985..1495003) /Source="Nicolas_upshift_promotors" /id="U1264" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=233 /SigmaFactorBS="tatacttttgcgccacttttgtcatgctgtcttccaaaaaGG TTTGAattttctggtcaatGGTTAAATATACATTGTCAccattttttggcgctgtaat t" /listShort="S555" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1495004) /Source="Nicolas_upshifts" /id="U1264" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=233 /SigmaFactorBS="tatacttttgcgccacttttgtcatgctgtcttccaaaaaGG TTTGAattttctggtcaatGGTTAAATATACATTGTCAccattttttggcgctgtaat t" /listShort="S555" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1495018..1495024) /Source="Nicolas_upshift_promotors" /id="U1264" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=233 /SigmaFactorBS="tatacttttgcgccacttttgtcatgctgtcttccaaaaaGG TTTGAattttctggtcaatGGTTAAATATACATTGTCAccattttttggcgctgtaat t" /listShort="S555" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1496408 /Source="Nicolas_upshifts" /id="D861" /incds=0 /nref=237 /ntot=257 /MaxReadThrough="1.141" /MaxDrop="6.28059" /score="3.41058446" /energy="-7.4" /TU="NA" /idTUdmin="U1263" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 1496480..1496485 /Source="Nicolas_upshift_promotors" /id="U1265" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=993 /SigmaFactorBS="tatgcaggctttctttttttatgccttcagaggagcatcGTT CTAcctgtccaaattcagGCATAAAATGAAACAAGCCtaaataaggagtgaacggtct c" /listShort="spoVD" /listLong="S556, S557, murE, S558, mraY" /label="promotor_-35" promotor_-10 1496501..1496519 /Source="Nicolas_upshift_promotors" /id="U1265" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=993 /SigmaFactorBS="tatgcaggctttctttttttatgccttcagaggagcatcGTT CTAcctgtccaaattcagGCATAAAATGAAACAAGCCtaaataaggagtgaacggtct c" /listShort="spoVD" /listLong="S556, S557, murE, S558, mraY" /label="promotor_-10" upshifts 1496501 /Source="Nicolas_upshifts" /id="U1265" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=993 /SigmaFactorBS="tatgcaggctttctttttttatgccttcagaggagcatcGTT CTAcctgtccaaattcagGCATAAAATGAAACAAGCCtaaataaggagtgaacggtct c" /listShort="spoVD" /listLong="S556, S557, murE, S558, mraY" /label="upshifts" CDS 1496542..1498482 /gene="spoVD" /locus_tag="BSU_15170" /old_locus_tag="BSU15170" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:8244929, 8289242, 9006059, 28383125" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8244929, 8289242, 9006059, 28383125; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="transpeptidase penicillin-binding protein" /protein_id="NP_389400.2" /db_xref="EnsemblGenomes-Gn:BSU15170" /db_xref="EnsemblGenomes-Tr:CAB13390" /db_xref="GOA:Q03524" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR005311" /db_xref="InterPro:IPR005543" /db_xref="InterPro:IPR011927" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR036138" /db_xref="SubtiList:BG10222" /db_xref="UniProtKB/Swiss-Prot:Q03524" /translation="MRVSNVTVRKRLLFVLLFGVIVFLIIDTRLGYVQFVMGEKLTSL AKDSWSRNLPFEPERGEILDRNGVKLATNKSAPTVFVVPRQVQNPMKTSKQLAAVLNM SEEKVYKHVTKKASIEKITPEGRKISNEKAKEIKALDLKGVYVAEDSIRHYPFGSFLS HVLGFAGIDNQGLLGLEAYYDDDLKGEKGSVKFYTDAKGKKMPDEADDYTPPKDGLDM KLTVDSKVQTIMERELDNAEAKYHPDGMIAVAMNPKNGEILGMSSRPDFDPADYQSVD PSVYNRNLPVWSTYEPGSTFKIITLAAALEEQKVNLKRDQFYDKGHAEVDGARLRCWK RGGHGLQTYLEVVQNSCNPGFVELGERLGKEKLFKYIKDFGFGQKTGIDLQGEGTGIL FPLERVGPVEQATTAFGQGVSVTPIQQVAAVSAAVNGGTLYTPYIAKEWIDPVTKKTV KKQSPIAKKQVISEETSKQIRYALESVVAEGTGRNAFVEGYRVGGKTGTAQKVKDGKY LENNHIVSFIGFAPADDPSLVVYVAVDNPKGTIQFGGTVAAPIVGNIMRDSLPELGVK PRKNQIEKKYQWNDTKTIEVPNVVGMSVSDLESLLVNLNVDASGKGSKIVKQSPAAGT KVKEGSKIRVYLTEEDEKEAAD*" /label="spoVD CDS" gene 1496542..1498482 /gene="spoVD" /locus_tag="BSU_15170" /old_locus_tag="BSU15170" /label="spoVD gene" promotor_-35 1498278..1498284 /Source="Nicolas_upshift_promotors" /id="U1266" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.435564435564436" /psig="0.435564435564436" /xcortree=578 /SigmaFactorBS="gaaaaatcaaatcgagaaaaaataccaatggaaCGACACAaa aacaatagaagtTCCGAATGTtgtagggatgtctgtctcagatcttgagtcactattg g" /listShort="S556, S557, murE, S558, mraY, murD, spoVE, S559, murG" /listLong="murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ, S561, bpr" /label="promotor_-35" promotor_-10 1498299..1498307 /Source="Nicolas_upshift_promotors" /id="U1266" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.435564435564436" /psig="0.435564435564436" /xcortree=578 /SigmaFactorBS="gaaaaatcaaatcgagaaaaaataccaatggaaCGACACAaa aacaatagaagtTCCGAATGTtgtagggatgtctgtctcagatcttgagtcactattg g" /listShort="S556, S557, murE, S558, mraY, murD, spoVE, S559, murG" /listLong="murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ, S561, bpr" /label="promotor_-10" upshifts 1498305 /Source="Nicolas_upshifts" /id="U1266" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.435564435564436" /psig="0.435564435564436" /xcortree=578 /SigmaFactorBS="gaaaaatcaaatcgagaaaaaataccaatggaaCGACACAaa aacaatagaagtTCCGAATGTtgtagggatgtctgtctcagatcttgagtcactattg g" /listShort="S556, S557, murE, S558, mraY, murD, spoVE, S559, murG" /listLong="murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ, S561, bpr" /label="upshifts" downshifts 1498455 /Source="Nicolas_upshifts" /id="D862" /incds=0 /nref=19 /ntot=91 /MaxReadThrough="4.23549" /MaxDrop="4.37308" /score="-3.90592085" /energy="-13.6" /TU="U1265,U1266" /idTUdmin="U1265" /TUdmin="-91" /isTUend="FALSE" /label="downshifts" S_feature 1498500..1498567 /Source="Nicolas_S_feature" /locus_tag="new_1586172_1586239" /HighExp="C30, G180, G135, ferm, MG 15, G150, MG 45, MG-0.1, MG 10, MG 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.436" /TUlongSig="SigEF" /TUlongPSig=1 /label="S556" promotor_-35 1498537..1498541 /Source="Nicolas_upshift_promotors" /id="U1267" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=2534 /SigmaFactorBS="gaaaaaatgctgatatctttcaagattaGCTGGatgtatcct tttattTACGCTAAAATATGAACTGTatgcttaaaatcattaccacatcatttgatgt g" /listShort="S557, murE, S558, mraY, murD, spoVE, S559, murG, murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ" /listLong="S561, bpr" /label="promotor_-35" promotor_-10 1498557..1498576 /Source="Nicolas_upshift_promotors" /id="U1267" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=2534 /SigmaFactorBS="gaaaaaatgctgatatctttcaagattaGCTGGatgtatcct tttattTACGCTAAAATATGAACTGTatgcttaaaatcattaccacatcatttgatgt g" /listShort="S557, murE, S558, mraY, murD, spoVE, S559, murG, murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ" /listLong="S561, bpr" /label="promotor_-10" S_feature 1498569..1498657 /Source="Nicolas_S_feature" /locus_tag="new_1586241_1586329" /HighExp="G180, G150, LBGexp, Paraq, G135, Oxctl, C30, dia0, Cold, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="1, 0.436" /TUlongSig="SigEF" /TUlongPSig=1 /label="S557" upshifts 1498569 /Source="Nicolas_upshifts" /id="U1267" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.834165834165834" /psig=1 /xcortree=2534 /SigmaFactorBS="gaaaaaatgctgatatctttcaagattaGCTGGatgtatcct tttattTACGCTAAAATATGAACTGTatgcttaaaatcattaccacatcatttgatgt g" /listShort="S557, murE, S558, mraY, murD, spoVE, S559, murG, murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ" /listLong="S561, bpr" /label="upshifts" CDS 1498658..1500142 /gene="murE" /locus_tag="BSU_15180" /old_locus_tag="BSU15180" /EC_number="6.3.2.13" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8436954, 10520745, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylmuramoylalanyl-D-glutamate-2, 6-diaminopimelate ligase" /protein_id="NP_389401.1" /db_xref="EnsemblGenomes-Gn:BSU15180" /db_xref="EnsemblGenomes-Tr:CAB13391" /db_xref="GOA:Q03523" /db_xref="InterPro:IPR000713" /db_xref="InterPro:IPR004101" /db_xref="InterPro:IPR005761" /db_xref="InterPro:IPR013221" /db_xref="InterPro:IPR035911" /db_xref="InterPro:IPR036565" /db_xref="InterPro:IPR036615" /db_xref="SubtiList:BG10223" /db_xref="UniProtKB/Swiss-Prot:Q03523" /translation="MKLTKLLTYLTTEPSVNDSQDPEITSIEMDSREVKKGSLFVCVK GYTVDGHDFAQKAVENGAAAIVAEREVDVNVPVIIVRQSLRALSVLSDAFYGQPTKKL QLIGITGTNGKTSTTHMVDEILKKAGKRTGLIGTMYMKIGDETLPVKNTTPESVTLQK TFKKMNDKHVDTAIMEVSSHALSLGRVHGCDYDIAVFTNLTQDHLDYHKTMDEYRHAK SLLFSQLGGAFNHEHPKRAVLNADDEASAYFEKVTAAHISTYGIKNDADVMAKNISIT AQGTSFDLVTNKGTKHITMSLVGQFNVYNVLAAVATCIAAGIPFEIITEAVEELHGVR GRFELVNQQQEFPVIVDYAHTPDSLENVLETCRDMTEGKLFVVVGCGGDRDKTKRPKM AKIAVELADEPIFTSDNPRSEDPRAILRDMEAGVENAYYHSIANREQAIFFAIANAKK GDVVLIAGKGHETYQQIGNETFDFDDAEVAARAIVELNKNKTNS*" /label="murE CDS" gene 1498658..1500142 /gene="murE" /locus_tag="BSU_15180" /old_locus_tag="BSU15180" /label="murE gene" S_feature 1500143..1500253 /Source="Nicolas_S_feature" /locus_tag="new_1587815_1587925" /HighExp="G180, G135, G150, C30, Oxctl, dia0, LBGexp, MG 25, Paraq, MG-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="1, 0.436" /TUlongSig="SigEF" /TUlongPSig=1 /label="S558" CDS 1500254..1501228 /gene="mraY" /locus_tag="BSU_15190" /old_locus_tag="BSU15190" /EC_number="2.7.8.13" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 15131133, 15849754, 16850406, 9592129, 24895118, 26620564, 27312048" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15131133, 15849754, 16850406, 9592129, 24895118, 26620564, 27312048; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phospho-N-acetylmuramoyl-pentapeptide undecaprenyl phosphate (C55P) transferase" /protein_id="NP_389402.2" /db_xref="EnsemblGenomes-Gn:BSU15190" /db_xref="EnsemblGenomes-Tr:CAB13392" /db_xref="GOA:Q03521" /db_xref="InterPro:IPR000715" /db_xref="InterPro:IPR003524" /db_xref="InterPro:IPR018480" /db_xref="SubtiList:BG10224" /db_xref="UniProtKB/Swiss-Prot:Q03521" /translation="MLEQVILFTILMGFLISVLLSPILIPFLRRLKFGQSIREEGPKS HQKKSGTPTMGGVMIILSIIVTTIVMTQKFSEISPEMVLLLFVTLGYGLLGFLDDYIK VVMKRNLGLTSKQKLIGQIIIAVVFYAVYHYYNFATDIRIPGTDLSFDLGWAYFILVL FMLVGGSNAVNLTDGLDGLLSGTAAIAFGAFAILAWNQSQYDVAIFSVAVVGAVLGFL VFNAHPAKVFMGDTGSLALGGAIVTIAILTKLEILLVIIGGVFVIETLSVILQVISFK TTGKRIFKMSPLHHHYELVGWSEWRVVVTFWAAGLLLAVLGIYIEVWL*" /label="mraY CDS" gene 1500254..1501228 /gene="mraY" /locus_tag="BSU_15190" /old_locus_tag="BSU15190" /label="mraY gene" CDS 1501229..1502584 /gene="murD" /locus_tag="BSU_15200" /old_locus_tag="BSU15200" /EC_number="6.3.2.9" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1765076, 9218784, 10966819; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylmuramoylalanyl-D-glutamate ligase" /protein_id="NP_389403.1" /db_xref="EnsemblGenomes-Gn:BSU15200" /db_xref="EnsemblGenomes-Tr:CAB13393" /db_xref="GOA:Q03522" /db_xref="InterPro:IPR004101" /db_xref="InterPro:IPR005762" /db_xref="InterPro:IPR013221" /db_xref="InterPro:IPR036565" /db_xref="InterPro:IPR036615" /db_xref="SubtiList:BG10225" /db_xref="UniProtKB/Swiss-Prot:Q03522" /translation="MENDQFLQKQHFLILGLAKSGYAAASILHEKGIYVAVNDQKPFE ENEPAQKLSEKGIEVVCGEHPVSLFDQHQITILIKNPGIPYENIMVQEAEKRGIPVWT EIELAYYLTSAKFIGITGSNGKTTTTTLIYEMLKADSQKALIAGNIGTVASEVAYHAD GDEWIVTELSSFQLMGTHAFRPEISLILNVFDAHLDYHHTRENYEKAKQKVYLHQTAS DKAIVNQDDETVVRLAEAGKAEIVPFSVSKTLEQGAYVKDSMIMFNGEAILPLEEVVL PGAHNLENILAAIAVVKTAGASNEAVKKVLTSFTGVKHRLQYVTTVNGRKFYNDSKAT NILATSKALSAFDKPVILLAGGLDRGNGFDDLKPYMKHVKAVLTFGQTAPKLEKLGNE LGIQHVKRVDNVEQAVSAAFALSNEGDVILLSPACASWDQFKTFEERGDMFIDAVHML K*" /label="murD CDS" gene 1501229..1502584 /gene="murD" /locus_tag="BSU_15200" /old_locus_tag="BSU15200" /label="murD gene" promotor_-35 1502408..1502413 /Source="Nicolas_upshift_promotors" /id="U1268" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.56943056943057" /psig="0.56943056943057" /xcortree=675 /SigmaFactorBS="caaaactcgagaaactcggcaatgaactgGGAATAcaacatg tcaaacgtGTCGATAATGTTGAACAAGcagtatctgcggcgtttgcgctctcaaatga a" /listShort="spoVE, S559, murG, murB, divIB, ylxW, ylxX, sbp" /listLong="S560, ftsA, ftsZ" /label="promotor_-35" promotor_-10 1502429..1502447 /Source="Nicolas_upshift_promotors" /id="U1268" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.56943056943057" /psig="0.56943056943057" /xcortree=675 /SigmaFactorBS="caaaactcgagaaactcggcaatgaactgGGAATAcaacatg tcaaacgtGTCGATAATGTTGAACAAGcagtatctgcggcgtttgcgctctcaaatga a" /listShort="spoVE, S559, murG, murB, divIB, ylxW, ylxX, sbp" /listLong="S560, ftsA, ftsZ" /label="promotor_-10" upshifts 1502439 /Source="Nicolas_upshifts" /id="U1268" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.56943056943057" /psig="0.56943056943057" /xcortree=675 /SigmaFactorBS="caaaactcgagaaactcggcaatgaactgGGAATAcaacatg tcaaacgtGTCGATAATGTTGAACAAGcagtatctgcggcgtttgcgctctcaaatga a" /listShort="spoVE, S559, murG, murB, divIB, ylxW, ylxX, sbp" /listLong="S560, ftsA, ftsZ" /label="upshifts" CDS 1502645..1503745 /gene="spoVE" /locus_tag="BSU_15210" /old_locus_tag="BSU15210" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:2509435, 9622350, 15849754, 16484183, 16850406, 27312048" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2509435, 9622350, 15849754, 16484183, 16850406, 27312048; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="factor for spore cortex peptidoglycan synthesis (stage V sporulation)" /protein_id="NP_389404.1" /db_xref="EnsemblGenomes-Gn:BSU15210" /db_xref="EnsemblGenomes-Tr:CAB13394" /db_xref="GOA:P07373" /db_xref="InterPro:IPR001182" /db_xref="InterPro:IPR013437" /db_xref="InterPro:IPR013438" /db_xref="InterPro:IPR018365" /db_xref="SubtiList:BG10226" /db_xref="UniProtKB/Swiss-Prot:P07373" /translation="MTTKKTSPDLLLVIITLLLLTIGLIMVYSASAVWADYKFDDSFF FAKRQLLFAGIGVIAMFFIMNVDYWTWRTWSKLLMVICFFLLVLVLIPGVGMVRNGSR SWIGVGAFSIQPSEFMKLAMIAFLAKFLSEKQKNITSFRRGFVPALGIVFSAFLIIMC QPDLGTGTVMVGTCIVMIFVAGARIAHFVFLGLIGLSGFVGLVLSAPYRIKRITSYLN PWEDPLGSGFQIIQSLYAVGPGGLFGMGLGQSRQKFFYLPEPQTDFIFAILSEELGFI GGTLILLLFSVLLWRGIRIALGAPDLYGSFVAVGIISMIAIQVMINIGVVTGLIPVTG ITLPFLSYGGSSLTLMLMAVGVLLNVSRYSRY*" /label="spoVE CDS" gene 1502645..1503745 /gene="spoVE" /locus_tag="BSU_15210" /old_locus_tag="BSU15210" /label="spoVE gene" S_feature 1503746..1503867 /Source="Nicolas_S_feature" /locus_tag="new_1591418_1591539" /HighExp="G180, C30, G135, G150, Oxctl, Paraq, LBGexp, dia0, S3, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA, Sig-" /TUshortPSig="0.569, 1, 0.436" /TUlongSig="NA" /TUlongPSig="NA" /label="S559" CDS 1503868..1504959 /gene="murG" /locus_tag="BSU_15220" /old_locus_tag="BSU15220" /EC_number="2.4.1.227" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9244290, 11042447, 12538870, 12682299, 12813070" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9244290, 11042447, 12538870, 12682299, 12813070; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylglucosamine-N-acetylmuramyl- (pentapeptide)pyrophosphoryl-undecaprenol N-acetylglucosamine transferase" /protein_id="NP_389405.2" /db_xref="EnsemblGenomes-Gn:BSU15220" /db_xref="EnsemblGenomes-Tr:CAB13395" /db_xref="GOA:P37585" /db_xref="InterPro:IPR004276" /db_xref="InterPro:IPR006009" /db_xref="InterPro:IPR007235" /db_xref="SubtiList:BG10227" /db_xref="UniProtKB/Swiss-Prot:P37585" /translation="MRIAISGGGTGGHIYPALAFIKEVQRRHPNVEFLYIGTENGLEK KIVERENIPFRSIEITGFKRKLSFENVKTVMRFLKGVKKSKSYLAEFKPDAVIGTGGY VCGPVVYAAAKMGIPTIVHEQNSLPGITNKFLSKYVNKVAICFEEAKSHFPSEKVVFT GNPRASEVVSIKTGRSLAEFGLSEDKKTVLIFGGSRGAAPINRAVIDMQDVLKTRDYQ VLYITGEVHYEKVMNELKSKGAADNMVTKPFLHQMPEYLKAIDVIVARAGATTIAEIT ALGIPSVLIPSPYVTANHQEVNARSLGQHDAAIVLKETELSGEKLIEALDRIVLNEQT LKEMSERTKSLGVPDAAARLYSVLEELKK*" /label="murG CDS" gene 1503868..1504959 /gene="murG" /locus_tag="BSU_15220" /old_locus_tag="BSU15220" /label="murG gene" promotor_-35 1504348..1504357 /Source="Nicolas_upshift_promotors" /id="U1269" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1645 /SigmaFactorBS="tcacattttcctagcgagaaagttgtatttacgGGAAACCCG AgagcctctgaagTCGTCTCAATAAAGACgggacgatcattggctgaatttgggcttt c" /listShort="murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ" /listLong="S561, bpr" /label="promotor_-35" promotor_-10 1504370..1504385 /Source="Nicolas_upshift_promotors" /id="U1269" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1645 /SigmaFactorBS="tcacattttcctagcgagaaagttgtatttacgGGAAACCCG AgagcctctgaagTCGTCTCAATAAAGACgggacgatcattggctgaatttgggcttt c" /listShort="murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ" /listLong="S561, bpr" /label="promotor_-10" upshifts 1504375 /Source="Nicolas_upshifts" /id="U1269" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1645 /SigmaFactorBS="tcacattttcctagcgagaaagttgtatttacgGGAAACCCG AgagcctctgaagTCGTCTCAATAAAGACgggacgatcattggctgaatttgggcttt c" /listShort="murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ" /listLong="S561, bpr" /label="upshifts" promotor_no_box 1504381..1504481 /Source="Nicolas_upshift_promotors" /id="U1270" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.363636363636364" /psig="0.0739260739260739" /xcortree=271 /SigmaFactorBS="aagacgggacgatcattggctgaatttgggctttctgaagac aaaaaaacggtcttaattttcggcggaagccgaggcgctgcaccgattaaccgcgctg t" /listShort="murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 1504441 /Source="Nicolas_upshifts" /id="U1270" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.363636363636364" /psig="0.0739260739260739" /xcortree=271 /SigmaFactorBS="aagacgggacgatcattggctgaatttgggctttctgaagac aaaaaaacggtcttaattttcggcggaagccgaggcgctgcaccgattaaccgcgctg t" /listShort="murB, divIB, ylxW, ylxX, sbp, S560, ftsA, ftsZ" /GFF_Attribute="listLong" /label="upshifts" CDS 1504991..1505902 /gene="murB" /locus_tag="BSU_15230" /old_locus_tag="BSU15230" /EC_number="1.3.1.98" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11327854, 12682299, 16484183, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylenolpyruvoylglucosamine reductase" /protein_id="NP_389406.1" /db_xref="EnsemblGenomes-Gn:BSU15230" /db_xref="EnsemblGenomes-Tr:CAB13396" /db_xref="GOA:P18579" /db_xref="InterPro:IPR003170" /db_xref="InterPro:IPR006094" /db_xref="InterPro:IPR011601" /db_xref="InterPro:IPR016166" /db_xref="InterPro:IPR016167" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR036318" /db_xref="InterPro:IPR036635" /db_xref="SubtiList:BG10228" /db_xref="UniProtKB/Swiss-Prot:P18579" /translation="MEKVIQELKEREVGKVLANEPLANHTTMKIGGPADVLVIPSSVD AVKDIMDVIKKYDVKWTVIGRGSNLLVLDEGIRGVVIKLGAGLDHLELEGEQVTVGGG YSVVRLATSLSKKGLSGLEFAAGIPGSVGGAVYMNAGAHGSDMSEILVKAHILFEDGT IEWLTNEQMDFSYRTSVLQKKRPGVCLEAVLQLEQKDKESIVQQMQSNKDYRKNTQPY SSPCAGSIFRNPLPNHAGNLVEKAGLKGYQIGGAKISEMHGNFIVNAGGASAKDVLDL IDHVKKTIREKYEIDMHTEVEIIGGNR*" /label="murB CDS" gene 1504991..1505902 /gene="murB" /locus_tag="BSU_15230" /old_locus_tag="BSU15230" /label="murB gene" downshifts 1505920 /Source="Nicolas_upshifts" /id="D863" /incds=0 /nref=2 /ntot=13 /MaxReadThrough="5.78428" /MaxDrop="2.8642" /score="-7.67573434" /energy="-7.4" /TU="U1267,U1268,U1269,U1270" /idTUdmin="U1266" /TUdmin=1809 /isTUend="FALSE" /label="downshifts" CDS 1506032..1506823 /gene="divIB" /locus_tag="BSU_15240" /old_locus_tag="BSU15240" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10852898, 12682299, 15659156, 16618922, 16936019, 16936026, 20460179, 20870765" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10852898, 12682299, 15659156, 16618922, 16936019, 16936026, 20460179, 20870765; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="cell-division initiation protein" /protein_id="NP_389407.1" /db_xref="EnsemblGenomes-Gn:BSU15240" /db_xref="EnsemblGenomes-Tr:CAB13397" /db_xref="GOA:P16655" /db_xref="InterPro:IPR005548" /db_xref="InterPro:IPR013685" /db_xref="InterPro:IPR026580" /db_xref="InterPro:IPR034746" /db_xref="SubtiList:BG10229" /db_xref="UniProtKB/Swiss-Prot:P16655" /translation="MNPGQDREKIVNIEERIPKIKEQRKQKANRRLISFIMLFFIMVL IIVYLQTPISKVSTISVTGNENVSKKEIIDLSDINSGDTEFWSLDKQKTEKKIQQNKL VKKAEISKSLPNKINIAIEEYKAIAYLEKDDVYYEVLENGSVLPNEVTPDDAGPILVN WTNAKKRSQMAKQLDALSNSLKQSISEIYYTPVKMDENRIKLYMNDGYVVTASIKTFA DRMKTYPSIISQLSSNKKGIIHLEVATYFEEFGKNDKAAKKEDEN*" /label="divIB CDS" gene 1506032..1506823 /gene="divIB" /locus_tag="BSU_15240" /old_locus_tag="BSU15240" /label="divIB gene" CDS 1506820..1507515 /gene="ylxW" /locus_tag="BSU_15250" /old_locus_tag="BSU15250" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16484183" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389408.2" /db_xref="EnsemblGenomes-Gn:BSU15250" /db_xref="EnsemblGenomes-Tr:CAB13398" /db_xref="GOA:C0SPA3" /db_xref="InterPro:IPR010273" /db_xref="SubtiList:BG11490" /db_xref="UniProtKB/Swiss-Prot:C0SPA3" /translation="MRGKSAVLLSLIMLIAGFLISFSFQMTKENNKSAAETEEWKKEY ALRDELLKQEKENKKFEKELYQKQNKVRQAENKLKKEKSEYYNVLEDTEKYRMYIGEV GVQGEGVEVTLEDASYIPEGENVNSYIVHESHIFQVVNELYISGAAAVAVNGQRLTHD SYIKCNGPVVTVDGVQHPAPFTVSAIGDPDVLLPSLNIAGGLIDQLSMDHISVSAEKE KNVQMKPILKTKE*" /label="ylxW CDS" gene 1506820..1507515 /gene="ylxW" /locus_tag="BSU_15250" /old_locus_tag="BSU15250" /label="ylxW gene" CDS 1507538..1508245 /gene="ylxX" /locus_tag="BSU_15260" /old_locus_tag="BSU15260" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16484183, 18179421" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389409.2" /db_xref="EnsemblGenomes-Gn:BSU15260" /db_xref="EnsemblGenomes-Tr:CAB13399" /db_xref="GOA:Q45544" /db_xref="InterPro:IPR010273" /db_xref="SubtiList:BG11489" /db_xref="UniProtKB/Swiss-Prot:Q45544" /translation="MKIKRSFISISVLMVIFGLMISVQFNSLKHPKVRDTRDMWDIRE ELTSEQKKQEKLLAEINKYDKLLNSYSQTKEMTKETALNNTLQSLKKTAGMTDITGSG IVITISPLFSESLTGEPIENPPPDLLKKLINELNSYGAEHISINERRVVNHTVIRDIN GTTKIDGYALDDYPLTVKVLAKDPDMLHSRVKGSGLEDLFASENLALKAGKSESKLTL KAYDRPLDVQQLKLLKD*" /label="ylxX CDS" gene 1507538..1508245 /gene="ylxX" /locus_tag="BSU_15260" /old_locus_tag="BSU15260" /label="ylxX gene" CDS 1508263..1508628 /gene="sbp" /locus_tag="BSU_15270" /old_locus_tag="BSU15270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 1569582, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein (small basic protein)" /protein_id="NP_389410.1" /db_xref="EnsemblGenomes-Gn:BSU15270" /db_xref="EnsemblGenomes-Tr:CAB13400" /db_xref="GOA:P28265" /db_xref="InterPro:IPR009709" /db_xref="SubtiList:BG10230" /db_xref="UniProtKB/Swiss-Prot:P28265" /translation="MWLPVLGLVLGIAIGLMTNLTIPSEYSNYLSLAVLAALDTLIGG IRAHLQGTYDEMVFVSGFFFNIILAISLAFLGVHLGVDLYLAGIFAFGVRLFQNIAVI RRNLLTKWTLSKKNKKNVI*" /label="sbp CDS" gene 1508263..1508628 /gene="sbp" /locus_tag="BSU_15270" /old_locus_tag="BSU15270" /label="sbp gene" promotor_-35 1508480..1508483 /Source="Nicolas_upshift_promotors" /id="U1271" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.474525474525474" /psig="0.98901098901099" /xcortree=2335 /SigmaFactorBS="aatattatattggcaataagtttagCTTTtctgggagtccat ctTGGTGTAGACTTGTATTTAGcaggtatattcgcatttggagtcagattatttcaga a" /listShort="S560, ftsA, ftsZ" /listLong="S561, bpr" /label="promotor_-35" promotor_-10 1508499..1508518 /Source="Nicolas_upshift_promotors" /id="U1271" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.474525474525474" /psig="0.98901098901099" /xcortree=2335 /SigmaFactorBS="aatattatattggcaataagtttagCTTTtctgggagtccat ctTGGTGTAGACTTGTATTTAGcaggtatattcgcatttggagtcagattatttcaga a" /listShort="S560, ftsA, ftsZ" /listLong="S561, bpr" /label="promotor_-10" upshifts 1508515 /Source="Nicolas_upshifts" /id="U1271" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.474525474525474" /psig="0.98901098901099" /xcortree=2335 /SigmaFactorBS="aatattatattggcaataagtttagCTTTtctgggagtccat ctTGGTGTAGACTTGTATTTAGcaggtatattcgcatttggagtcagattatttcaga a" /listShort="S560, ftsA, ftsZ" /listLong="S561, bpr" /label="upshifts" S_feature 1508629..1508801 /Source="Nicolas_S_feature" /locus_tag="new_1596301_1596473" /HighExp="T3.0H, T2.30H, S2, T3.30H, Lbtran, T4.0H, T5.0H, T1.30H, S1, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-, SigWXY, SigA" /TUshortPSig="0.989, 0.0739, 1, 1" /TUlongSig="SigEF, Sig-" /TUlongPSig="0.569, 0.436" /label="S560" CDS 1508802..1510124 /gene="ftsA" /locus_tag="BSU_15280" /old_locus_tag="BSU15280" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 15153768, 16159787, 16796675, 17015652, 23036588, 24224907" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15153768, 16159787, 16796675, 17015652, 23036588, 24224907; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="cell-division protein essential for Z-ring assembly" /protein_id="NP_389411.2" /db_xref="EnsemblGenomes-Gn:BSU15280" /db_xref="EnsemblGenomes-Tr:CAB13401" /db_xref="GOA:P28264" /db_xref="InterPro:IPR003494" /db_xref="InterPro:IPR020823" /db_xref="SubtiList:BG10231" /db_xref="UniProtKB/Swiss-Prot:P28264" /translation="MNNNELYVSLDIGTSNTKVIVGEMTDDSLNIIGVGNVPSEGLKK GSIVDIDETVHSIRKAFDQAERMVGFPLRKAIVGVNGNYINIQDTNGVVAVSSENKEI QVEDVRRVMEAAQVVSVPHEQLIVDVIPKQFIVDGRDEITDPKKMLGVRLEVEGTLIT GSKTILHNLLRCVERAGIEITDICLQPLAAGSAALSKDEKNLGVALIDIGGGSTTIAV FQNGHLTSTRVIPLGGENITKDISIGLRTSTEEAERVKKQLGHAYYDEASEDEIFEVT VIGTNQKQTFTQQEAANIIEARVEEILEIVSEELRSMGITDLPGGFVLTGGQAAMPGV MSLAQDVLQNNVRVASPNYIGVRDPQYMTGVGLIQFACRNARIQGRKIGFKMPEEAIQ EIAVSSSEEQEQHHHQNEVQQRPKGKQKTQAEHNKQSKMKKLLSMFWE*" /label="ftsA CDS" gene 1508802..1510124 /gene="ftsA" /locus_tag="BSU_15280" /old_locus_tag="BSU15280" /label="ftsA gene" upshifts complement(1509009) /Source="Nicolas_upshifts" /id="U1272" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96103896103896" /psig="0.001998001998002" /xcortree=70 /SigmaFactorBS="ttgtatcttgaatattgatataatttccattaaCGCCGacaa tagcttttctAAGCGgaaaacctaccattctttcagcttggtcaaacgcttttcttat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1509013..1509017) /Source="Nicolas_upshift_promotors" /id="U1272" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96103896103896" /psig="0.001998001998002" /xcortree=70 /SigmaFactorBS="ttgtatcttgaatattgatataatttccattaaCGCCGacaa tagcttttctAAGCGgaaaacctaccattctttcagcttggtcaaacgcttttcttat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1509032..1509036) /Source="Nicolas_upshift_promotors" /id="U1272" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96103896103896" /psig="0.001998001998002" /xcortree=70 /SigmaFactorBS="ttgtatcttgaatattgatataatttccattaaCGCCGacaa tagcttttctAAGCGgaaaacctaccattctttcagcttggtcaaacgcttttcttat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1510160..1511308 /gene="ftsZ" /locus_tag="BSU_15290" /old_locus_tag="BSU15290" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 12950927, 14527275, 15317782, 16159787, 16322744, 16549676, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 12950927, 14527275, 15317782, 16159787, 16322744, 16549676, 22720735; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="cell-division initiation protein" /protein_id="NP_389412.2" /db_xref="EnsemblGenomes-Gn:BSU15290" /db_xref="EnsemblGenomes-Tr:CAB13402" /db_xref="GOA:P17865" /db_xref="InterPro:IPR000158" /db_xref="InterPro:IPR003008" /db_xref="InterPro:IPR008280" /db_xref="InterPro:IPR018316" /db_xref="InterPro:IPR020805" /db_xref="InterPro:IPR024757" /db_xref="InterPro:IPR036525" /db_xref="InterPro:IPR037103" /db_xref="PDB:2RHH" /db_xref="PDB:2RHJ" /db_xref="PDB:2RHL" /db_xref="PDB:2RHO" /db_xref="PDB:2VAM" /db_xref="PDB:2VXY" /db_xref="PDB:4U39" /db_xref="SubtiList:BG10232" /db_xref="UniProtKB/Swiss-Prot:P17865" /translation="MLEFETNIDGLASIKVIGVGGGGNNAVNRMIENEVQGVEYIAVN TDAQALNLSKAEVKMQIGAKLTRGLGAGANPEVGKKAAEESKEQIEEALKGADMVFVT AGMGGGTGTGAAPVIAQIAKDLGALTVGVVTRPFTFEGRKRQLQAAGGISAMKEAVDT LIVIPNDRILEIVDKNTPMLEAFREADNVLRQGVQGISDLIATPGLINLDFADVKTIM SNKGSALMGIGIATGENRAAEAAKKAISSPLLEAAIDGAQGVLMNITGGTNLSLYEVQ EAADIVASASDQDVNMIFGSVINENLKDEIVVTVIATGFIEQEKDVTKPQRPSLNQSI KTHNQSVPKREPKREEPQQQNTVSRHTSQPADDTLDIPTFLRNRNKRG*" /label="ftsZ CDS" gene 1510160..1511308 /gene="ftsZ" /locus_tag="BSU_15290" /old_locus_tag="BSU15290" /label="ftsZ gene" downshifts 1511282 /Source="Nicolas_upshifts" /id="D864" /incds=0 /nref=226 /ntot=389 /MaxReadThrough="2.85051" /MaxDrop="7.70428" /score="34.7919519" /energy="-13.7" /TU="U1267,U1271" /idTUdmin="U1269" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" S_feature 1511507..1511610 /Source="Nicolas_S_feature" /locus_tag="new_1599179_1599282" /HighExp="T5.0H, BC, T4.0H, T3.30H, T3.0H, S2, BT, M9-stat, T2.30H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.953" /TUlongSig="SigA, SigWXY, SigA, Sig-" /TUlongPSig="0.989, 1, 1, 0.436" /label="S561" upshifts 1511507 /Source="Nicolas_upshifts" /id="U1273" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.453546453546454" /psig="0.953046953046953" /xcortree=486 /SigmaFactorBS="tttttatcattttcatatatatggaaattgaatgacatgaaa cgacaatatctgtaattcagATTGTCTACAGTTAATATACagcgatgttctgacaaac c" /listShort="S561, bpr" /GFF_Attribute="listLong" /label="upshifts" misc_feature 1511509..1511528 /Source="Nicolas_upshift_promotors" /id="U1273" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.453546453546454" /psig="0.953046953046953" /xcortree=486 /SigmaFactorBS="tttttatcattttcatatatatggaaattgaatgacatgaaa cgacaatatctgtaattcagATTGTCTACAGTTAATATACagcgatgttctgacaaac c" /listShort="S561, bpr" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 1511611..1515912 /gene="bpr" /locus_tag="BSU_15300" /old_locus_tag="BSU15300" /EC_number="3.4.21.-" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1368833, 1938892, 2106512, 2108961, 15205417, 15375126, 18194340, 18414485, 26497454" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1368833, 1938892, 2106512, 2108961, 15205417, 15375126, 18194340, 18414485, 26497454; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bacillopeptidase F" /protein_id="NP_389413.1" /db_xref="EnsemblGenomes-Gn:BSU15300" /db_xref="EnsemblGenomes-Tr:CAB13403" /db_xref="GOA:P16397" /db_xref="InterPro:IPR000209" /db_xref="InterPro:IPR008757" /db_xref="InterPro:IPR008969" /db_xref="InterPro:IPR008979" /db_xref="InterPro:IPR010259" /db_xref="InterPro:IPR012103" /db_xref="InterPro:IPR013320" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR015500" /db_xref="InterPro:IPR022398" /db_xref="InterPro:IPR023828" /db_xref="InterPro:IPR033857" /db_xref="InterPro:IPR036852" /db_xref="InterPro:IPR037045" /db_xref="SubtiList:BG10233" /db_xref="UniProtKB/Swiss-Prot:P16397" /translation="MRKKTKNRLISSVLSTVVISSLLFPGAAGASSKVTSPSVKKELQ SAESIQNKISSSLKKSFKKKEKTTFLIKFKDLANPEKAAKAAVKKAKSKKLSAAKTEY QKRSAVVSSLKVTADESQQDVLKYLNTQKDKGNADQIHSYYVVNGIAVHASKEVMEKV VQFPEVEKVLPNEKRQLFKSSSPFNMKKAQKAIKATDGVEWNVDQIDAPKAWALGYDG TGTVVASIDTGVEWNHPALKEKYRGYNPENPNEPENEMNWYDAVAGEASPYDDLAHGT HVTGTMVGSEPDGTNQIGVAPGAKWIAVKAFSEDGGTDADILEAGEWVLAPKDAEGNP HPEMAPDVVNNSWGGGSGLDEWYRDMVNAWRAADIFPEFSAGNTDLFIPGGPGSIANP ANYPESFATGATDINKKLADFSLQGPSPYDEIKPEISAPGVNIRSSVPGQTYEDGWDG TSMAGPHVSAVAALLKQANASLSVDEMEDILTSTAEPLTDSTFPDSPNNGYGHGLVNA FDAVSAVTDGLGKAEGQVSVEGDDQEPPVYQHEKVTEAYEGGSLPLTLTAEDNVSVTS VKLSYKLDQGEWTEITAKRISGDHLKGTYQAEIPDIKGTKLSYKWMIHDFGGHVVSSD VYDVTVKPSITAGYKQDFETAPGGWVASGTNNNWEWGVPSTGPNTAASGEKVYGTNLT GNYANSANMNLVMPPIKAPDSGSLFLQFKSWHNLEDDFDYGYVFVLPEGEKNWEQAGV YNGKTSSWTDEEIDLSAYKGQNIQVMFNLQSDESIAKEGWYIDDVVLSDKSAGKTVKK NKLGVEKPSGKQKKKPVNPKKAKPSANTAVKHQNKAIQPQVLPLKAQVSVVETGKSTY SDQSTGQYTLKHKAGDYTLMAEAYGYQSKTQKVSLKTDQTTQANFTLEEMKKGTLKGT VINKTTGEPVTGASVYVVEDAAVEPAMTNDKGEYMLEAYEGAYTIKVAAPGYYSDEFS VELKGDVTKETALKPFVGYPGEIAYDDGTAENANSYFAAGNGWAVKMTLADGKDKGML TGGLFRFWDTEFPDPGGTEFKVEVYDATGKDGAPGKKIAGPFNAEALRNGEWTKVDLS SKGIMVDKDFYLVYIQSKPDPYSPGLAMDETGQNSGRNWQYIDGKWQPGDKADGNYMI RALVDYEAAVPEITSPTDKSYTNKDSVTVKGNASPGTTVHIYNGEKEAGETKAAADGT FHAGIILNKGENELTATASTDNGTTDASSPITVTLDQEKPELTLDNPKDGGKTNKETL TVKGAVSDDNLKDVKVNGKKATVADGSYSARILLENGRNEIKVIATDLAGNKTTKKTV IDVNFDKPVISGLIPGEDKNLKAGESVKIAFSSAEDLDATFTIRMPLTNARASVQNAT ELPLREISPGRYEGYWTATSSIKAKGAKVEVIVRDDYGNETRKTANGKLNMNTEN*" /label="bpr CDS" gene 1511611..1515912 /gene="bpr" /locus_tag="BSU_15300" /old_locus_tag="BSU15300" /label="bpr gene" downshifts 1515909 /Source="Nicolas_upshifts" /id="D865" /incds=0 /nref=73 /ntot=169 /MaxReadThrough="0.90839" /MaxDrop="8.78054" /score="38.0577497" /energy="-11.4" /TU="NA" /idTUdmin="U1273" /TUdmin=1 /isTUend="TRUE" /label="downshifts" S_feature complement(1515920..1517062) /Source="Nicolas_S_feature" /locus_tag="new_1603592_1604734_c" /HighExp="S8, S6, S7, S5, LoTm, S4, B36, T5.0H, BT, B60" /AntisenseName="spoIIGA" /AntisenseCor="0.71080549463714104" /AntisenseRegPval="-42" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.579" /TUlongSig="NA" /TUlongPSig="NA" /label="S562" downshifts complement(1515962) /Source="Nicolas_upshifts" /id="D866" /incds=0 /nref=5 /ntot=22 /MaxReadThrough="2.36451" /MaxDrop="3.61596" /score="22.1321546" /energy="-9.6" /TU="NA" /idTUdmin="U1275" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 1516040..1516106 /Source="Nicolas_S_feature" /locus_tag="new_1603712_1603778" /HighExp="M9-stat, T5.0H, S4, LoTm, T3.30H, T3.0H, B60, S3, S5, S7" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.534" /TUlongSig="NA" /TUlongPSig="NA" /label="S563" upshifts 1516042 /Source="Nicolas_upshifts" /id="U1274" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.282717282717283" /psig="0.534465534465534" /xcortree=966 /SigmaFactorBS="gcagatttccctgaaaaattgtattttcctctcaacattaat tgacagactttcccacagaGCTTGCTTTATACTTATGAAgcaagaaggggaacagcgt g" /listShort="S563, spoIIGA, sigE, S564, sigG, S565" /listLong="ylmA, NA, thiQ" /label="upshifts" misc_feature 1516043..1516062 /Source="Nicolas_upshift_promotors" /id="U1274" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.282717282717283" /psig="0.534465534465534" /xcortree=966 /SigmaFactorBS="gcagatttccctgaaaaattgtattttcctctcaacattaat tgacagactttcccacagaGCTTGCTTTATACTTATGAAgcaagaaggggaacagcgt g" /listShort="S563, spoIIGA, sigE, S564, sigG, S565" /listLong="ylmA, NA, thiQ" /label="promotor_single_box" /note="Geneious type: promotor_single_box" misc_feature complement(1516060..1516072) /Source="Nicolas_upshift_promotors" /id="U1275" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.430569430569431" /psig="0.185814185814186" /xcortree=1053 /SigmaFactorBS="caaatgacatctaaatagattttcacatctgactcctttctt tcttgcctcacgctgttcCCCTTCTTGCTTCataagtataaagcaagctctgtgggaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1516072) /Source="Nicolas_upshifts" /id="U1275" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.430569430569431" /psig="0.185814185814186" /xcortree=1053 /SigmaFactorBS="caaatgacatctaaatagattttcacatctgactcctttctt tcttgcctcacgctgttcCCCTTCTTGCTTCataagtataaagcaagctctgtgggaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 1516107..1517036 /gene="spoIIGA" /locus_tag="BSU_15310" /old_locus_tag="BSU15310" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:7585939, 7729420, 9573195, 9663680, 10498732, 15849754, 16850406, 18378688, 21362630, 22111992" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7585939, 7729420, 9573195, 9663680, 10498732, 15849754, 16850406, 18378688, 21362630, 22111992; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protease processing pro-sigma-E" /protein_id="NP_389414.1" /db_xref="EnsemblGenomes-Gn:BSU15310" /db_xref="EnsemblGenomes-Tr:CAB13405" /db_xref="GOA:P13801" /db_xref="InterPro:IPR005081" /db_xref="SubtiList:BG10234" /db_xref="UniProtKB/Swiss-Prot:P13801" /translation="MKIYLDVIWLLNFCFDALLLLLTAFILKRHVKKRRLVGGAFIGS SIVLLMFTPFSPIVEHPAGKLAFSVVIVVVTFGFKRFRFFFQNLFSFYFATFLMGGGI IGAHSLLQSNSIVQNGVMITNQTGFGDPISWLFIVGGFPALWFFSKRRIEDIETKNIQ YEERVSVQADLGSQTLHVRGLIDSGNQLYDPLTKTPVMIIYIDKLEPIFGTAETMIIR NTDPLEAIEQLDDSFRFLDKMRLIPYRGVGQQNQFLLCVKPDHVTIMTKEEMISADKC LIGISTTKLSADGEFDAIIHPKMLSGKAVKHVS*" /label="spoIIGA CDS" gene 1516107..1517036 /gene="spoIIGA" /locus_tag="BSU_15310" /old_locus_tag="BSU15310" /label="spoIIGA gene" promotor_-10 complement(1517051..1517070) /Source="Nicolas_upshift_promotors" /id="U1276" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.494505494505495" /psig="0.57942057942058" /xcortree=1054 /SigmaFactorBS="gtcaaccgtaatttcagttttttcatcttcctctccCTTCta aatgtcacgccgTTTGAGTATGATAAGTAACGgacatttgcgaacattatgaaacgtg t" /listShort="S562" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1517064) /Source="Nicolas_upshifts" /id="U1276" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.494505494505495" /psig="0.57942057942058" /xcortree=1054 /SigmaFactorBS="gtcaaccgtaatttcagttttttcatcttcctctccCTTCta aatgtcacgccgTTTGAGTATGATAAGTAACGgacatttgcgaacattatgaaacgtg t" /listShort="S562" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1517085..1517088) /Source="Nicolas_upshift_promotors" /id="U1276" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.494505494505495" /psig="0.57942057942058" /xcortree=1054 /SigmaFactorBS="gtcaaccgtaatttcagttttttcatcttcctctccCTTCta aatgtcacgccgTTTGAGTATGATAAGTAACGgacatttgcgaacattatgaaacgtg t" /listShort="S562" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1517099..1517818 /gene="sigE" /locus_tag="BSU_15320" /old_locus_tag="BSU15320" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1581961, 7708009, 8464402, 15187183, 20802044" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1581961, 7708009, 8464402, 15187183, 20802044; Product type f: factor" /codon_start=1 /transl_table=11 /product="RNA polymerase sporulation-specific sigma-29 factor (sigma-E)" /protein_id="NP_389415.2" /db_xref="EnsemblGenomes-Gn:BSU15320" /db_xref="EnsemblGenomes-Tr:CAB13406" /db_xref="GOA:P06222" /db_xref="InterPro:IPR000943" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR007630" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014200" /db_xref="InterPro:IPR014284" /db_xref="SubtiList:BG10235" /db_xref="UniProtKB/Swiss-Prot:P06222" /translation="MKKLKLRLTHLWYKLLMKLGLKSDEVYYIGGSEALPPPLSKDEE QVLLMKLPNGDQAARAILIERNLRLVVYIARKFENTGINIEDLISIGTIGLIKAVNTF NPEKKIKLATYASRCIENEILMYLRRNNKIRSEVSFDEPLNIDWDGNELLLSDVLGTD DDIITKDIEANVDKKLLKKALEQLNEREKQIMELRFGLVGEEEKTQKDVADMMGISQS YISRLEKRIIKRLRKEFNKMV*" /label="sigE CDS" gene 1517099..1517818 /gene="sigE" /locus_tag="BSU_15320" /old_locus_tag="BSU15320" /label="sigE gene" S_feature 1517819..1517908 /Source="Nicolas_S_feature" /locus_tag="new_1605491_1605580" /HighExp="T5.0H, S3, M9-stat, T4.0H, S4, LoTm, S2, B60, B36, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.534" /TUlongSig="NA" /TUlongPSig="NA" /label="S564" promotor_-35 1517892..1517898 /Source="Nicolas_upshift_promotors" /id="U1277" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.923076923076923" /psig="0.923076923076923" /xcortree=1135 /SigmaFactorBS="cagggatttcctgatttcgacagtttttcggtctgagtgcag TGCATATttttcccacccaaGGAGATACTTAAcgttgtacagcagctcctgtagggag g" /listShort="sigG" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1517910 /Source="Nicolas_upshifts" /id="U1277" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.923076923076923" /psig="0.923076923076923" /xcortree=1135 /SigmaFactorBS="cagggatttcctgatttcgacagtttttcggtctgagtgcag TGCATATttttcccacccaaGGAGATACTTAAcgttgtacagcagctcctgtagggag g" /listShort="sigG" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1517912..1517923 /Source="Nicolas_upshift_promotors" /id="U1277" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.923076923076923" /psig="0.923076923076923" /xcortree=1135 /SigmaFactorBS="cagggatttcctgatttcgacagtttttcggtctgagtgcag TGCATATttttcccacccaaGGAGATACTTAAcgttgtacagcagctcctgtagggag g" /listShort="sigG" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1517958..1518740 /gene="sigG" /locus_tag="BSU_15330" /old_locus_tag="BSU15330" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15187183, 15256570, 16166546, 16497325, 17015665, 21935351" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15187183, 15256570, 16166546, 16497325, 17015665, 21935351; Product type f : factor" /codon_start=1 /transl_table=11 /product="RNA polymerase sporulation-specific sigma factor(sigma-G)" /protein_id="NP_389416.1" /db_xref="EnsemblGenomes-Gn:BSU15330" /db_xref="EnsemblGenomes-Tr:CAB13407" /db_xref="GOA:P19940" /db_xref="InterPro:IPR000943" /db_xref="InterPro:IPR007624" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR007630" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014212" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR014322" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10236" /db_xref="UniProtKB/Swiss-Prot:P19940" /translation="MSRNKVEICGVDTSKLPVLKNEEMRKLFRQLQDEGDDSAREKLV NGNLRLVLSVIQRFNNRGEYVDDLFQVGCIGLMKSIDNFDLSHNVKFSTYAVPMIIGE IRRYLRDNNPIRVSRSLRDIAYKALQVRERLISETSKEPTAEDIAKVLEVPHEEIVFA LDAIQDPVSLFEPIYNDGGDPIYVMDQISDERNTDSQWIEELALKEGMRRLNDREKMI LRKRFFQGKTQMEVAEEIGISQAQVSRLEKAAIKQMNKNIHQ*" /label="sigG CDS" gene 1517958..1518740 /gene="sigG" /locus_tag="BSU_15330" /old_locus_tag="BSU15330" /label="sigG gene" S_feature 1518741..1518829 /Source="Nicolas_S_feature" /locus_tag="new_1606413_1606501" /HighExp="LoTm, S7, S8, BT, S6, S4, G/S, S3, S2, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.534" /TUlongSig="NA" /TUlongPSig="NA" /label="S565" promotor_-35 1518794..1518801 /Source="Nicolas_upshift_promotors" /id="U1278" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.323676323676324" /psig="0.98901098901099" /xcortree=2908 /SigmaFactorBS="aggcttttctattgattatggatGGTTTACGttttggaaaaa gTAAGGTATCCTAGTTCGTACaaagttttatgaaaattaaaacaattataaaaggcaa t" /listShort="ylmA, NA, thiQ, ylmC, S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1518814..1518833 /Source="Nicolas_upshift_promotors" /id="U1278" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.323676323676324" /psig="0.98901098901099" /xcortree=2908 /SigmaFactorBS="aggcttttctattgattatggatGGTTTACGttttggaaaaa gTAAGGTATCCTAGTTCGTACaaagttttatgaaaattaaaacaattataaaaggcaa t" /listShort="ylmA, NA, thiQ, ylmC, S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1518831 /Source="Nicolas_upshifts" /id="U1278" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.323676323676324" /psig="0.98901098901099" /xcortree=2908 /SigmaFactorBS="aggcttttctattgattatggatGGTTTACGttttggaaaaa gTAAGGTATCCTAGTTCGTACaaagttttatgaaaattaaaacaattataaaaggcaa t" /listShort="ylmA, NA, thiQ, ylmC, S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="upshifts" CDS 1518888..1519682 /gene="ylmA" /locus_tag="BSU_15340" /old_locus_tag="BSU15340" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16707683, 18083814; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_389417.2" /db_xref="EnsemblGenomes-Gn:BSU15340" /db_xref="EnsemblGenomes-Tr:CAB13408" /db_xref="GOA:O31723" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13370" /db_xref="UniProtKB/Swiss-Prot:O31723" /translation="MILQLDNVSLKRNGKWILKDIHWKVEEKENWVLYGLNGAGKTAL LNMLCSYYFPTSGEMQVLGHEFGKTELGEKLRRKIGLVSAALQQKLYPADSAFEIALS GAYASIGLYETPSKETREKAIGLLEDLGAIEYADRRYETLSQGEKQRALIARALMADP ELLILDEPVTGLDFIAREKLLDTITYIANKENAPSILYVTHHAEEILPVFDKALLLKQ GEVFGSGEIKEMLTDQILSAFFDTPIHVLWNQDRPFLTRAEPITNA*" /label="ylmA CDS" gene 1518888..1519682 /gene="ylmA" /locus_tag="BSU_15340" /old_locus_tag="BSU15340" /label="ylmA gene" promotor_-35 1519600..1519603 /Source="Nicolas_upshift_promotors" /id="U1279" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.9000999000999" /psig="0.976023976023976" /xcortree=567 /SigmaFactorBS="ataaaggaaatgcttactgatcaaatactttccgCTTTtttt gatacgccaaTCCATGTATTATGGAATCAGgatcggccgtttttaacaagagctgagc c" /listShort="NA, thiQ, ylmC, S566" /listLong="ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /label="promotor_-35" promotor_-10 1519618..1519637 /Source="Nicolas_upshift_promotors" /id="U1279" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.9000999000999" /psig="0.976023976023976" /xcortree=567 /SigmaFactorBS="ataaaggaaatgcttactgatcaaatactttccgCTTTtttt gatacgccaaTCCATGTATTATGGAATCAGgatcggccgtttttaacaagagctgagc c" /listShort="NA, thiQ, ylmC, S566" /listLong="ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /label="promotor_-10" upshifts 1519626 /Source="Nicolas_upshifts" /id="U1279" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.9000999000999" /psig="0.976023976023976" /xcortree=567 /SigmaFactorBS="ataaaggaaatgcttactgatcaaatactttccgCTTTtttt gatacgccaaTCCATGTATTATGGAATCAGgatcggccgtttttaacaagagctgagc c" /listShort="NA, thiQ, ylmC, S566" /listLong="ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /label="upshifts" misc_RNA 1519695..1519796 /gene="tswE" /locus_tag="BSU_misc_RNA_24" /product="thiamine pyrophosphate riboswitch" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11470904, 12410317, 15862294, 16728979, 16962976, 17307816, 18179415, 18776013; Product type n: RNA" /function="16.3: Control" /label="tswE RNA" gene 1519695..1519796 /gene="tswE" /locus_tag="BSU_misc_RNA_24" /label="tswE gene" downshifts 1519783 /Source="Nicolas_upshifts" /id="D867" /incds=0 /nref=7 /ntot=53 /MaxReadThrough="5.58534" /MaxDrop="4.3688" /score="-2.39598083" /energy="-7.1" /TU="U1278,U1279" /idTUdmin="U1274" /TUdmin=971 /isTUend="FALSE" /label="downshifts" CDS 1519884..1521164 /gene="thiQ" /locus_tag="BSU_15350" /old_locus_tag="BSU15350" /EC_number="3.5.1.-" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17618314" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17618314; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-formyl-4-amino-5-aminomethyl-2- methylpyrimidinedeformylase" /protein_id="NP_389418.2" /db_xref="EnsemblGenomes-Gn:BSU15350" /db_xref="EnsemblGenomes-Tr:CAB13409" /db_xref="GOA:O31724" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR010182" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG13371" /db_xref="UniProtKB/Swiss-Prot:O31724" /translation="MDQQIYSLQKKVEEHKEELIQLAKTLISYQTPAPPARNTEGIQS WIAGYLNELGFSIDKWDVYPGDPNVVGKLKGTDSADYYSLIINGHVDVAEVKEDEEWK HDPFHPIEKNGLLIGRGASDMKGGMACVLFAVKLIREASIELPGDLILQSVIGEEVGE AGTLECCKRGYHADFAIVADTSDMHIQGQGGVITGWIEIKSSQTFHDGTRRNMIHAGG GTFGASAIEKMAKIIAGLGELERHWSIMKSYPGFKPGTNTINPAVIEGGRHAAFIADE CRLWITVHFYPNETHDQVAAEIEDYVNRLSDSDIWLRENRPVFKWGGSSMIEDRGEIF PALEVDPGHPGVLALTASHQKVKRECPIIDVSQSVTDGGWLYDAGIPCVIYGPGDLHN AHSVNEKVSIEQLVEYTKIILDFIISWCSRKKEQ*" /label="thiQ CDS" gene 1519884..1521164 /gene="thiQ" /locus_tag="BSU_15350" /old_locus_tag="BSU15350" /label="thiQ gene" misc_feature complement(1521105..1521121) /Source="Nicolas_upshift_promotors" /id="U1280" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.407592407592408" /psig="0.715284715284715" /xcortree=1716 /SigmaFactorBS="ttcatgtcattgttcttttttccggctgcaccagctgatgat aaaatcgAGTATAATTTTTGTATActctactagctgctcaatcgataccttctcgttc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1521110) /Source="Nicolas_upshifts" /id="U1280" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.407592407592408" /psig="0.715284715284715" /xcortree=1716 /SigmaFactorBS="ttcatgtcattgttcttttttccggctgcaccagctgatgat aaaatcgAGTATAATTTTTGTATActctactagctgctcaatcgataccttctcgttc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1521185..1521190 /Source="Nicolas_upshift_promotors" /id="U1281" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1082 /SigmaFactorBS="aaaaaagaacaatgacatgaaaatttcttcttgctGACAAGg ttcagcctgcccgtTCATATACTTGAACAAAAGgacggaaaaaggacgtgatggaatg a" /listShort="ylmC, S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA" /listLong="NA, ileS" /label="promotor_-35" promotor_-10 1521206..1521224 /Source="Nicolas_upshift_promotors" /id="U1281" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1082 /SigmaFactorBS="aaaaaagaacaatgacatgaaaatttcttcttgctGACAAGg ttcagcctgcccgtTCATATACTTGAACAAAAGgacggaaaaaggacgtgatggaatg a" /listShort="ylmC, S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA" /listLong="NA, ileS" /label="promotor_-10" upshifts 1521210 /Source="Nicolas_upshifts" /id="U1281" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1082 /SigmaFactorBS="aaaaaagaacaatgacatgaaaatttcttcttgctGACAAGg ttcagcctgcccgtTCATATACTTGAACAAAAGgacggaaaaaggacgtgatggaatg a" /listShort="ylmC, S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA" /listLong="NA, ileS" /label="upshifts" CDS 1521247..1521492 /gene="ylmC" /locus_tag="BSU_15360" /old_locus_tag="BSU15360" /experiment="publication(s) with functional evidences, PMID:12429060, 23396918" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12429060, 23396918; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="essential sporulation protein" /protein_id="NP_389419.1" /db_xref="EnsemblGenomes-Gn:BSU15360" /db_xref="EnsemblGenomes-Tr:CAB13410" /db_xref="InterPro:IPR011033" /db_xref="InterPro:IPR014238" /db_xref="InterPro:IPR027275" /db_xref="SubtiList:BG13372" /db_xref="UniProtKB/Swiss-Prot:O31725" /translation="MISISEFQVKDVVNVSNGKKLGSIGDIDINVTTGKIQAIILGGN GKVLGFFGKEEELVIPWRNIVKIGEDVILVRLSEPHA*" /label="ylmC CDS" gene 1521247..1521492 /gene="ylmC" /locus_tag="BSU_15360" /old_locus_tag="BSU15360" /label="ylmC gene" promotor_-35 1521408..1521416 /Source="Nicolas_upshift_promotors" /id="U1282" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=534 /SigmaFactorBS="aaatgggaaagttctcggattttttggaaaagaAGAGGAATT ggtcattccaTGGCGAAATATAGTAAAAAtcggggaagatgtaatcttagtccgatta a" /listShort="S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1521427..1521445 /Source="Nicolas_upshift_promotors" /id="U1282" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=534 /SigmaFactorBS="aaatgggaaagttctcggattttttggaaaagaAGAGGAATT ggtcattccaTGGCGAAATATAGTAAAAAtcggggaagatgtaatcttagtccgatta a" /listShort="S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1521435 /Source="Nicolas_upshifts" /id="U1282" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=534 /SigmaFactorBS="aaatgggaaagttctcggattttttggaaaagaAGAGGAATT ggtcattccaTGGCGAAATATAGTAAAAAtcggggaagatgtaatcttagtccgatta a" /listShort="S566, ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="upshifts" S_feature 1521493..1521603 /Source="Nicolas_S_feature" /locus_tag="new_1609165_1609275" /HighExp="T3.0H, S2, S1, T4.0H, T3.30H, T5.0H, T2.0H, BC, Gly, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.34150000000000003" /TUshortSig="SigH, SigEF, SigA, SigA" /TUshortPSig="1, 0.998, 0.976, 0.989" /TUlongSig="NA" /TUlongPSig="NA" /label="S566" misc_feature 1521595..1521614 /Source="Nicolas_upshift_promotors" /id="U1283" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.884115884115884" /psig=1 /xcortree=2210 /SigmaFactorBS="cacatttcatttagaaatatgcaaatcggcgctcaacgaatg cagtaagaTGTGGTAAAATAAGTGGGAAattccgcttttttaaatgtttgtcgaaagg t" /listShort="ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1521605 /Source="Nicolas_upshifts" /id="U1283" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.884115884115884" /psig=1 /xcortree=2210 /SigmaFactorBS="cacatttcatttagaaatatgcaaatcggcgctcaacgaatg cagtaagaTGTGGTAAAATAAGTGGGAAattccgcttttttaaatgtttgtcgaaagg t" /listShort="ylmD, ylmE, sepF, ylmG, ylmH, S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="upshifts" CDS 1521655..1522491 /gene="ylmD" /locus_tag="BSU_15370" /old_locus_tag="BSU15370" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16498617, 19737354; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="conserved protein with laccase domain" /protein_id="NP_389420.1" /db_xref="EnsemblGenomes-Gn:BSU15370" /db_xref="EnsemblGenomes-Tr:CAB13411" /db_xref="GOA:O31726" /db_xref="InterPro:IPR003730" /db_xref="InterPro:IPR011324" /db_xref="SubtiList:BG13373" /db_xref="UniProtKB/Swiss-Prot:O31726" /translation="MNTYHPFSLTTPSTLMIQDWAQTNQNNKEVIAGFTTKNGGVSQK PFESLNTGLHVHDKDADVVKNREYIADMFNTDLQSWVFADQTHDNRVQKVTQRDRGKG AREYHTALKATDGIYTNEKNVFLALCFADCVPLFFYDPVKSLVGVAHAGWKGTVKQIG REMVKQWTEKEGSNPSDIYAVIGPSISGACYTVDDRVMDAVRALPVSADLAANQTAKA QYQLDLKELNRLILMDSGLASEQISVSGLCTESEPSLFYSHRRDQGKTGRMMSFIGMK EA*" /label="ylmD CDS" gene 1521655..1522491 /gene="ylmD" /locus_tag="BSU_15370" /old_locus_tag="BSU15370" /label="ylmD gene" CDS 1522498..1523190 /gene="ylmE" /locus_tag="BSU_15380" /old_locus_tag="BSU15380" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14526035, 24097949; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative PLP-containing enzyme" /protein_id="NP_389421.1" /db_xref="EnsemblGenomes-Gn:BSU15380" /db_xref="EnsemblGenomes-Tr:CAB13412" /db_xref="GOA:O31727" /db_xref="InterPro:IPR001608" /db_xref="InterPro:IPR011078" /db_xref="InterPro:IPR029066" /db_xref="SubtiList:BG13374" /db_xref="UniProtKB/Swiss-Prot:O31727" /translation="MRVVDNLRHINERINEACNRSGRSSDEVTVIAVTKYVSPERAQE AVDAGITCLGENRDAELLRKQELMKGNPEWHFIGSLQSRKAKSVVNSVSYIHSLDRLS LAKEIEKRAEGTVRCFVQVNTSLEPSKHGMKKEEVIPFIQELSGFEHILVAGLMTMAP LTDDQDQIRSCFRSLRELRDQVQKLNQPNAPCTELSMGMSNDFEIAIEEGATYIRIGS SLVGNETGGVQQ*" /label="ylmE CDS" gene 1522498..1523190 /gene="ylmE" /locus_tag="BSU_15380" /old_locus_tag="BSU15380" /label="ylmE gene" CDS 1523187..1523642 /gene="sepF" /locus_tag="BSU_15390" /old_locus_tag="BSU15390" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:14526035, 16420366, 16796675, 18782755, 22912848, 24218584" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14526035, 16420366, 16796675, 18782755, 22912848, 24218584; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="cell division machinery factor" /protein_id="NP_389422.3" /db_xref="EnsemblGenomes-Gn:BSU15390" /db_xref="EnsemblGenomes-Tr:CAB13413" /db_xref="GOA:O31728" /db_xref="InterPro:IPR007561" /db_xref="InterPro:IPR023052" /db_xref="PDB:3ZIH" /db_xref="PDB:3ZII" /db_xref="SubtiList:BG13375" /db_xref="UniProtKB/Swiss-Prot:O31728" /translation="MSMKNKLKNFFSMEDEEYEYEYIETERESHEEHEQKEKPAYNGN KPAGKQNVVSLQSVQKSSKVVLSEPRVYAEAQEIADHLKNRRAVVVNLQRIQHDQAKR IVDFLSGTVYAIGGDIQRIGSDIFLCTPDNVDVSGTISELISEDEHQRW*" /label="sepF CDS" gene 1523187..1523642 /gene="sepF" /locus_tag="BSU_15390" /old_locus_tag="BSU15390" /label="sepF gene" CDS 1523649..1523921 /gene="ylmG" /locus_tag="BSU_15400" /old_locus_tag="BSU15400" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14526035, 19966467, 20359373; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor involved in shape determination, distribution of nucleoids and osmotic tolerance" /protein_id="NP_389423.1" /db_xref="EnsemblGenomes-Gn:BSU15400" /db_xref="EnsemblGenomes-Tr:CAB13414" /db_xref="GOA:O31729" /db_xref="InterPro:IPR003425" /db_xref="SubtiList:BG13376" /db_xref="UniProtKB/Swiss-Prot:O31729" /translation="MILYQVFSVLSLLITIYSFALIIYIFMSWVPSTRETAVGRFLAS ICEPYLEPFRKIIPPIAMLDISPIVAILVLRFATTGLWGLYRMIAF*" /label="ylmG CDS" gene 1523649..1523921 /gene="ylmG" /locus_tag="BSU_15400" /old_locus_tag="BSU15400" /label="ylmG gene" downshifts 1523910 /Source="Nicolas_upshifts" /id="D868" /incds=0 /nref=16 /ntot=97 /MaxReadThrough="6.19839" /MaxDrop="4.93537" /score="-6.17078585" /energy="-15.2" /TU="U1278,U1281,U1282,U1283" /idTUdmin="U1281" /TUdmin="-1452" /isTUend="FALSE" /label="downshifts" CDS 1523982..1524755 /gene="ylmH" /locus_tag="BSU_15410" /old_locus_tag="BSU15410" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10093218, 14526035, 21141807; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor involved in shape determination, RNA-binding fold" /protein_id="NP_389424.1" /db_xref="EnsemblGenomes-Gn:BSU15410" /db_xref="EnsemblGenomes-Tr:CAB13415" /db_xref="GOA:P71020" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG11856" /db_xref="UniProtKB/Swiss-Prot:P71020" /translation="MSDIYQHFRKDERAFIDQALEWKRIVQEQYRMKLTDFLDPREQV ILSAVTGQADVGLAFSGGYDRAERKRAILFPEYITPEESDFELQAFNVRYADKFVSVD HRSLLGALMGIGLKRQKFGDIVFSETAVQLIVSADTADFVAAQLTQAGKAAVSLEKID LSDLNIPAVDVEIRDDTVSSLRLDAVCASMSRQSRQKSQTLVKNGLVKVNWKVVEDPS YIVAEGDMLSIRGFGRCSLTKIEGKTKKDKWRVTFERQK*" /label="ylmH CDS" gene 1523982..1524755 /gene="ylmH" /locus_tag="BSU_15410" /old_locus_tag="BSU15410" /label="ylmH gene" promotor_-35 1524471..1524478 /Source="Nicolas_upshift_promotors" /id="U1284" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=1638 /SigmaFactorBS="aatcgacttgtcagacCTTAACATtccagcagttgatGTCGA AATAAGAGATGACAcggtttcttctttaaggcttgacgccgtctgcgcctctatgagc a" /listShort="S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1524492..1524510 /Source="Nicolas_upshift_promotors" /id="U1284" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=1638 /SigmaFactorBS="aatcgacttgtcagacCTTAACATtccagcagttgatGTCGA AATAAGAGATGACAcggtttcttctttaaggcttgacgccgtctgcgcctctatgagc a" /listShort="S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1524515 /Source="Nicolas_upshifts" /id="U1284" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=1638 /SigmaFactorBS="aatcgacttgtcagacCTTAACATtccagcagttgatGTCGA AATAAGAGATGACAcggtttcttctttaaggcttgacgccgtctgcgcctctatgagc a" /listShort="S567, divIVA, NA, ileS" /GFF_Attribute="listLong" /label="upshifts" S_feature 1524756..1524848 /Source="Nicolas_S_feature" /locus_tag="new_1612428_1612520" /HighExp="C90, M0t90, C30, GM-0.1, Glucon, MG 5, GM 45, GM 5, GM 60, GM 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigA, SigH, SigEF, SigA" /TUshortPSig="0.973, 1, 1, 0.998, 0.989" /TUlongSig="SigA" /TUlongPSig="0.976" /label="S567" CDS 1524849..1525343 /gene="divIVA" /locus_tag="BSU_15420" /old_locus_tag="BSU15420" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10724454, 12950914, 14526035, 15165232, 15554965, 16885474, 22108385, 22582279, 23264578, 24129255, 28674273" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10724454, 12950914, 14526035, 15165232, 15554965, 16885474, 22108385, 22582279, 23264578, 24129255, 28674273; Product type f : factor" /codon_start=1 /transl_table=11 /product="cell-division initiation protein" /protein_id="NP_389425.1" /db_xref="EnsemblGenomes-Gn:BSU15420" /db_xref="EnsemblGenomes-Tr:CAB13416" /db_xref="GOA:P71021" /db_xref="InterPro:IPR007793" /db_xref="InterPro:IPR019933" /db_xref="PDB:2WUJ" /db_xref="PDB:2WUK" /db_xref="SubtiList:BG11835" /db_xref="UniProtKB/Swiss-Prot:P71021" /translation="MPLTPNDIHNKTFTKSFRGYDEDEVNEFLAQVRKDYEIVLRKKT ELEAKVNELDERIGHFANIEETLNKSILVAQEAAEDVKRNSQKEAKLIVREAEKNADR IINESLSKSRKIAMEIEELKKQSKVFRTRFQMLIEAQLDLLKNDDWDHLLEYEVDAVF EEKE*" /label="divIVA CDS" gene 1524849..1525343 /gene="divIVA" /locus_tag="BSU_15420" /old_locus_tag="BSU15420" /label="divIVA gene" promotor_-35 1525356..1525363 /Source="Nicolas_upshift_promotors" /id="U1285" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.556443556443556" /psig="0.999000999001" /xcortree=597 /SigmaFactorBS="tatttgaggaaaaggaataaattctctgattaTCTTGACAtt ttcttagcttgTCGAATATAATACGTTCATAaattcagatgaaaaaacggttgaaagg g" /listShort="NA, ileS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1525377..1525396 /Source="Nicolas_upshift_promotors" /id="U1285" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.556443556443556" /psig="0.999000999001" /xcortree=597 /SigmaFactorBS="tatttgaggaaaaggaataaattctctgattaTCTTGACAtt ttcttagcttgTCGAATATAATACGTTCATAaattcagatgaaaaaacggttgaaagg g" /listShort="NA, ileS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1525384 /Source="Nicolas_upshifts" /id="U1285" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.556443556443556" /psig="0.999000999001" /xcortree=597 /SigmaFactorBS="tatttgaggaaaaggaataaattctctgattaTCTTGACAtt ttcttagcttgTCGAATATAATACGTTCATAaattcagatgaaaaaacggttgaaagg g" /listShort="NA, ileS" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 1525406..1525632 /gene="iswA" /locus_tag="BSU_misc_RNA_25" /product="T-box riboswitch specific of isoleucine tRNA" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 1317842, 9098041, 12165569, 12547201; Product type n: RNA" /label="iswA RNA" gene 1525406..1525632 /gene="iswA" /locus_tag="BSU_misc_RNA_25" /label="iswA gene" downshifts 1525599 /Source="Nicolas_upshifts" /id="D869" /incds=0 /nref=43 /ntot=100 /MaxReadThrough="7.76706" /MaxDrop="5.97038" /score="48.8352635" /energy="-19.4" /TU="U1278,U1282,U1283,U1284,U1285" /idTUdmin="U1281" /TUdmin=237 /isTUend="FALSE" /label="downshifts" CDS 1525685..1528450 /gene="ileS" /locus_tag="BSU_15430" /old_locus_tag="BSU15430" /EC_number="6.1.1.5" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 16697013, 17043414, 17095543, 28139725; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isoleucyl-tRNA synthetase" /protein_id="NP_389426.2" /db_xref="EnsemblGenomes-Gn:BSU15430" /db_xref="EnsemblGenomes-Tr:CAB13417" /db_xref="GOA:Q45477" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR002300" /db_xref="InterPro:IPR002301" /db_xref="InterPro:IPR009008" /db_xref="InterPro:IPR009080" /db_xref="InterPro:IPR013155" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR023585" /db_xref="InterPro:IPR033708" /db_xref="SubtiList:BG11792" /db_xref="UniProtKB/Swiss-Prot:Q45477" /translation="MDFKDTLLMPKTDFPMRGNLPNREPDIQKKWEEEDIYRLVQERT KDRPKFVLHDGPPYANGDIHMGHALNKILKDFIVRYKSMSGYNAPYVPGWDTHGLPIE TALTKNKKVNRKEMSVAEFRKLCEEYAWKQIEGQREQFKRLGVRGDWENPYVTLKPEY EAQQIRVFGEMAKRGYIYKGLKPVNWSPSSESALAEAEIEYQDKRSASIYVAFGVKDG KGVLENGERIIIWTTTPWTIPANLGISVHPDLEYSVIAVGEDRFVVASALVENVASAC GFDQYEVTRTVKGKDLENIIAEHPLYGRDSLVMLGEHVTTDAGTGCVHTAPGHGEDDF IIGQKYGLDVLCPVDEKGVMTSEAPGFEGMFYDDANKAITQQLDEKGALVKLEFITHS YPHDWRTKKPTIFRATAQWFASIKDFRSDLLDAIKETKWVPEWGEQRLHNMVRDRGDW CISRQRAWGVPIPVFYAENGEPVITDETIEHVSELFRQHGSNIWFEKEAKDLLPEGFT HPGSPNGTFTKEQDIMDVWFDSGSSHQAVLEERDDLVRPADLYLEGSDQYRGWFNSSL STAVAVTGKAPYKGVLSHGFALDGEGRKMSKSIGNVVVPAKVMKQLGADILRLWVSSV DYQADVRVSDAILKQVAEVYRKIRNTFRFLHGNLFDFDPKTNAVAVEDLREVDQYMLI KLNKLIDKVKKAYDEYEFAVVYHSIHNFCTIELSSFYLDFAKDIVYIEHADHPDRRSM QTVFYETLLALVKLSAPILPHTADELWSHLTFVEEQSVQLTDMPETITVPNSEATEEK FDRFMALRDDVLKALETARNEKIIGKSLEANLKLYPNKENKELLASIKENLSQLFIVS ELTISEENEAPNDAQSFATGKIAVEKAEGEMCERSRVISKDVGANPKYPTLSLRNAEI VEKYYQK*" /label="ileS CDS" gene 1525685..1528450 /gene="ileS" /locus_tag="BSU_15430" /old_locus_tag="BSU15430" /label="ileS gene" downshifts 1528441 /Source="Nicolas_upshifts" /id="D870" /incds=0 /nref=233 /ntot=261 /MaxReadThrough="2.6695" /MaxDrop="6.91924" /score="40.2175565" /energy="-13.9" /TU="NA" /idTUdmin="U1278" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" downshifts complement(1528496) /Source="Nicolas_upshifts" /id="D871" /incds=0 /nref=6 /ntot=17 /MaxReadThrough="1.29709" /MaxDrop="3.66645" /score="13.8608728" /energy="-15.6" /TU="NA" /idTUdmin="U1275" /TUdmin="-12534" /isTUend="FALSE" /label="downshifts" promotor_-35 1528531..1528537 /Source="Nicolas_upshift_promotors" /id="U1286" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=855 /SigmaFactorBS="aagagtgacatcctttagaacgaaaggaaaaatcttatgGGC TTTAgatcatcattcacaGGCAACAATAAAgatactacgttaagagcaggagttgtga a" /listShort="ylyA, lspA, rluD" /listLong="NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE" /label="promotor_-35" promotor_-10 1528552..1528563 /Source="Nicolas_upshift_promotors" /id="U1286" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=855 /SigmaFactorBS="aagagtgacatcctttagaacgaaaggaaaaatcttatgGGC TTTAgatcatcattcacaGGCAACAATAAAgatactacgttaagagcaggagttgtga a" /listShort="ylyA, lspA, rluD" /listLong="NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE" /label="promotor_-10" upshifts 1528552 /Source="Nicolas_upshifts" /id="U1286" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=855 /SigmaFactorBS="aagagtgacatcctttagaacgaaaggaaaaatcttatgGGC TTTAgatcatcattcacaGGCAACAATAAAgatactacgttaagagcaggagttgtga a" /listShort="ylyA, lspA, rluD" /listLong="NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE" /label="upshifts" CDS 1528595..1528969 /gene="ylyA" /locus_tag="BSU_15440" /old_locus_tag="BSU15440" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15496987, 23123912, 23678950" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15496987, 23123912, 23678950; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="sporulation-related RNA polymerase-binding factor" /protein_id="NP_389427.2" /db_xref="EnsemblGenomes-Gn:BSU15440" /db_xref="EnsemblGenomes-Tr:CAB13418" /db_xref="GOA:Q45478" /db_xref="InterPro:IPR000962" /db_xref="InterPro:IPR016841" /db_xref="InterPro:IPR020458" /db_xref="SubtiList:BG11795" /db_xref="UniProtKB/Swiss-Prot:Q45478" /translation="MNDQLTAIYTELLLMKEELQSRLFEYSCFQVSTSPQAAINQKQK ATLIYHIKEELQDVLLALSKIENGTFGYCEETGAPIPLAKLAVLPTARTANDFLYSVQ FEKKTLPIWKSTDIEYGQALYE*" /label="ylyA CDS" gene 1528595..1528969 /gene="ylyA" /locus_tag="BSU_15440" /old_locus_tag="BSU15440" /label="ylyA gene" promotor_-35 1529001..1529005 /Source="Nicolas_upshift_promotors" /id="U1287" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.953046953046953" /psig=1 /xcortree=2549 /SigmaFactorBS="gtatgaataacagtgtctgtccggttaatatgcctgatattT CTTTactccagtgctttttATTGATAAAATGCATAATGGattaaagtaaccgtaaact g" /listShort="lspA, rluD, NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE, S568" /listLong="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /label="promotor_-35" upshifts 1529020 /Source="Nicolas_upshifts" /id="U1287" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.953046953046953" /psig=1 /xcortree=2549 /SigmaFactorBS="gtatgaataacagtgtctgtccggttaatatgcctgatattT CTTTactccagtgctttttATTGATAAAATGCATAATGGattaaagtaaccgtaaact g" /listShort="lspA, rluD, NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE, S568" /listLong="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /label="upshifts" promotor_-10 1529021..1529040 /Source="Nicolas_upshift_promotors" /id="U1287" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.953046953046953" /psig=1 /xcortree=2549 /SigmaFactorBS="gtatgaataacagtgtctgtccggttaatatgcctgatattT CTTTactccagtgctttttATTGATAAAATGCATAATGGattaaagtaaccgtaaact g" /listShort="lspA, rluD, NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE, S568" /listLong="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /label="promotor_-10" CDS 1529072..1529536 /gene="lspA" /locus_tag="BSU_15450" /old_locus_tag="BSU15450" /EC_number="3.4.23.36" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9880550, 9882689, 10497172, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9880550, 9882689, 10497172, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="signal peptidase II" /protein_id="NP_389428.1" /db_xref="EnsemblGenomes-Gn:BSU15450" /db_xref="EnsemblGenomes-Tr:CAB13419" /db_xref="GOA:Q45479" /db_xref="InterPro:IPR001872" /db_xref="SubtiList:BG11793" /db_xref="UniProtKB/Swiss-Prot:Q45479" /translation="MLYYMIALLIIAADQLTKWLVVKNMELGQSIPIIDQVFYITSHR NTGAAWGILAGQMWFFYLITTAVIIGIVYYIQRYTKGQRLLGVALGLMLGGAIGNFID RAVRQEVVDFIHVIIVNYNYPIFNIADSSLCVGVMLLFIQMLLDSGKKKKEQ*" /label="lspA CDS" gene 1529072..1529536 /gene="lspA" /locus_tag="BSU_15450" /old_locus_tag="BSU15450" /label="lspA gene" CDS 1529538..1530449 /gene="rluD" /locus_tag="BSU_15460" /old_locus_tag="BSU15460" /EC_number="4.2.1.-" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15078091, 15928344, 17188032, 17937767, 18032607, 20817755; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="pseudouridylate synthase" /protein_id="NP_389429.3" /db_xref="EnsemblGenomes-Gn:BSU15460" /db_xref="EnsemblGenomes-Tr:CAB13420" /db_xref="GOA:Q45480" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR006145" /db_xref="InterPro:IPR006224" /db_xref="InterPro:IPR006225" /db_xref="InterPro:IPR020103" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG11796" /db_xref="UniProtKB/Swiss-Prot:Q45480" /translation="MNQIDITASEEQKSERIDKFLASTENDWSRTQVQQWVKDGQVVV NGSAVKANYKIQPGDQVTVTVPEPEALDVLAEPMDLDIYYEDQDVLVVNKPRGMVVHP APGHLTGTLVNGLMAHCTDLSGINGVMRPGIVHRIDKDTSGLLMVAKNDMAHESLVNQ LVNKTVTRKYTAVVHGLISHDDGTIDAPIGRDKKDRQSMTVTRDGKNAVTHFHVLERF QDFTLVECQLETGRTHQIRVHMKYIGFPLAGDPKYGPRKTIDFNGQALHAGVLGFDHP RTGEYVEFEAPLPEDMAELIENLRKNG*" /label="rluD CDS" gene 1529538..1530449 /gene="rluD" /locus_tag="BSU_15460" /old_locus_tag="BSU15460" /label="rluD gene" promotor_-35 1530444..1530451 /Source="Nicolas_upshift_promotors" /id="U1288" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.785214785214785" /psig=1 /xcortree=2423 /SigmaFactorBS="ttaatcgaaaacctcagaaaaaacGGTTGACAgagggtttct tttcTGAAATAATAAACGAAGCTGaatagattctttaaaacagtccagagaggctgag a" /listShort="NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE, S568" /listLong="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /label="promotor_-35" promotor_-10 1530466..1530485 /Source="Nicolas_upshift_promotors" /id="U1288" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.785214785214785" /psig=1 /xcortree=2423 /SigmaFactorBS="ttaatcgaaaacctcagaaaaaacGGTTGACAgagggtttct tttcTGAAATAATAAACGAAGCTGaatagattctttaaaacagtccagagaggctgag a" /listShort="NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE, S568" /listLong="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /label="promotor_-10" upshifts 1530480 /Source="Nicolas_upshifts" /id="U1288" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.785214785214785" /psig=1 /xcortree=2423 /SigmaFactorBS="ttaatcgaaaacctcagaaaaaacGGTTGACAgagggtttct tttcTGAAATAATAAACGAAGCTGaatagattctttaaaacagtccagagaggctgag a" /listShort="NA, pyrR, NA, pyrP, NA, pyrB, pyrC, pyrAA, pyrAB, pyrK, pyrD, pyrF, pyrE, S568" /listLong="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /label="upshifts" misc_RNA 1530489..1530605 /gene="pyaA" /locus_tag="BSU_misc_RNA_26" /product="pyrimidine biosynthesis operon attenuator" /experiment="publication(s) with functional evidences, PMID:7868607, 8206849, 8636037, 8955403, 9488732, 9932459, 11726695, 12787499, 15252202" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7868607, 8206849, 8636037, 8955403, 9488732, 9932459, 11726695, 12787499, 15252202; Product type n: RNA" /label="pyaA RNA" gene 1530489..1530605 /gene="pyaA" /locus_tag="BSU_misc_RNA_26" /label="pyaA gene" CDS 1530632..1531177 /gene="pyrR" /locus_tag="BSU_15470" /old_locus_tag="BSU15470" /EC_number="2.4.2.9" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:7798145, 9932459, 12482852, 15716449, 17322189, 18678934" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7798145, 9932459, 12482852, 15716449, 17322189, 18678934; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional attenuator and uracil phosphoribosyltransferase activity" /protein_id="NP_389430.1" /db_xref="EnsemblGenomes-Gn:BSU15470" /db_xref="EnsemblGenomes-Tr:CAB13421" /db_xref="GOA:P39765" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR023050" /db_xref="InterPro:IPR029057" /db_xref="PDB:1A3C" /db_xref="PDB:1A4X" /db_xref="PDB:4P82" /db_xref="SubtiList:BG10712" /db_xref="UniProtKB/Swiss-Prot:P39765" /translation="MNQKAVILDEQAIRRALTRIAHEMIERNKGMNNCILVGIKTRGI YLAKRLAERIEQIEGNPVTVGEIDITLYRDDLSKKTSNDEPLVKGADIPVDITDQKVI LVDDVLYTGRTVRAGMDALVDVGRPSSIQLAVLVDRGHRELPIRADYIGKNIPTSKSE KVMVQLDEVDQNDLVAIYENE*" /label="pyrR CDS" gene 1530632..1531177 /gene="pyrR" /locus_tag="BSU_15470" /old_locus_tag="BSU15470" /label="pyrR gene" downshifts complement(1530826) /Source="Nicolas_upshifts" /id="D872" /incds=1 /nref=1 /ntot=47 /MaxReadThrough="1.85132" /MaxDrop="2.50006" /score="0.812637138" /energy="-7" /TU="NA" /idTUdmin="U1275" /TUdmin="-14864" /isTUend="FALSE" /label="downshifts" downshifts 1531168 /Source="Nicolas_upshifts" /id="D873" /incds=0 /nref=13 /ntot=149 /MaxReadThrough="8.16191" /MaxDrop="3.4492" /score="16.3570883" /energy="-11.5" /TU="U1287,U1288" /idTUdmin="U1286" /TUdmin=704 /isTUend="FALSE" /label="downshifts" misc_RNA 1531181..1531298 /gene="pyaB" /locus_tag="BSU_misc_RNA_27" /product="pyrimidine biosynthesis operon attenuator" /experiment="publication(s) with functional evidences, PMID:7868607, 8206849, 8636037, 8955403, 9488732, 9932459, 11726695, 12787499, 15252202" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7868607, 8206849, 8636037, 8955403, 9488732, 9932459, 11726695, 12787499, 15252202; Product type n: RNA" /label="pyaB RNA" gene 1531181..1531298 /gene="pyaB" /locus_tag="BSU_misc_RNA_27" /label="pyaB gene" CDS 1531351..1532658 /gene="pyrP" /locus_tag="BSU_15480" /old_locus_tag="BSU15480" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 8206848, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="uracil permease" /protein_id="NP_389431.2" /db_xref="EnsemblGenomes-Gn:BSU15480" /db_xref="EnsemblGenomes-Tr:CAB13422" /db_xref="GOA:P39766" /db_xref="InterPro:IPR006042" /db_xref="InterPro:IPR006043" /db_xref="InterPro:IPR029935" /db_xref="SubtiList:BG10992" /db_xref="UniProtKB/Swiss-Prot:P39766" /translation="MSKKKVNLGVRDVPTPFSWVSFSLQHLFAMFGSTILVPKLVGMS PAVALVTSGIGTLAYLLITKGQIPAYLGSSFAFISPIILVKATGGPGAAMVGAFLAGL VYGLIALLIRQLGTGWLMKILPPVVVGPVIIVIGLGLASTAVNMAMYADPNASELVYS LKHFSVAGVTLAITIICAIFLRGFLSLIPVLIGIIGGYLFALTQGIVNFQPVLDAKWF AVPEFIIPFKDYSPSVTLGIAAAMVPVAFVTMSEHIGHQMVLSKVVGQDFIKKPGLHR SIMGDSVATILASLIGGPPTTTYGENIGVLAITRVFSVFVIGGAAVIALCFGFIGKIS ALISSVPSAVMGGVSFLLFGIIASSGLRMLIDNKIDYENNRNLIITSVILVIGVGGAF IQVSQGGFQVSGMALAAIVGVILNLILPQAKEEQADTSEQHHI*" /label="pyrP CDS" gene 1531351..1532658 /gene="pyrP" /locus_tag="BSU_15480" /old_locus_tag="BSU15480" /label="pyrP gene" misc_RNA 1532659..1532773 /gene="pyaC" /locus_tag="BSU_misc_RNA_28" /product="pyrimidine biosynthesis operon attenuator" /experiment="publication(s) with functional evidences, PMID:7868607, 8206849, 8636037, 8955403, 9488732, 9932459, 11726695, 12787499, 15252202" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7868607, 8206849, 8636037, 8955403, 9488732, 9932459, 11726695, 12787499, 15252202; Product type n: RNA" /label="pyaC RNA" gene 1532659..1532773 /gene="pyaC" /locus_tag="BSU_misc_RNA_28" /label="pyaC gene" CDS 1532804..1533718 /gene="pyrB" /locus_tag="BSU_15490" /old_locus_tag="BSU15490" /EC_number="2.1.3.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8535162, 16321950, 21663747" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8535162, 16321950, 21663747; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aspartate carbamoyltransferase" /protein_id="NP_389432.2" /db_xref="EnsemblGenomes-Gn:BSU15490" /db_xref="EnsemblGenomes-Tr:CAB13423" /db_xref="GOA:P05654" /db_xref="InterPro:IPR002082" /db_xref="InterPro:IPR006130" /db_xref="InterPro:IPR006131" /db_xref="InterPro:IPR006132" /db_xref="InterPro:IPR036901" /db_xref="PDB:2AT2" /db_xref="PDB:3R7D" /db_xref="PDB:3R7F" /db_xref="PDB:3R7L" /db_xref="SubtiList:BG10713" /db_xref="UniProtKB/Swiss-Prot:P05654" /translation="MKHLTTMSELSTEEIKDLLQTAQELKSGKTDNQLTGKFAANLFF EPSTRTRFSFEVAEKKLGMNVLNLDGTSTSVQKGETLYDTIRTLESIGVDVCVIRHSE DEYYEELVSQVNIPILNAGDGCGQHPTQSLLDLMTIYEEFNTFKGLTVSIHGDIKHSR VARSNAEVLTRLGARVLFSGPSEWQDEENTFGTYVSMDEAVESSDVVMLLRIQNERHQ SAVSQEGYLNKYGLTVERAERMKRHAIIMHPAPVNRGVEIDDSLVESEKSRIFKQMKN GVFIRMAVIQRALQTNVKRGEAAYVISH*" /label="pyrB CDS" gene 1532804..1533718 /gene="pyrB" /locus_tag="BSU_15490" /old_locus_tag="BSU15490" /label="pyrB gene" CDS 1533702..1534988 /gene="pyrC" /locus_tag="BSU_15500" /old_locus_tag="BSU15500" /EC_number="3.5.2.3" /function="2: Purines, pyrimidines, nucleosides, and nucleotides" /experiment="publication(s) with functional evidences, PMID:7516791, 16522191, 21045288" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7516791, 16522191, 21045288; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydroorotase" /protein_id="NP_389433.2" /db_xref="EnsemblGenomes-Gn:BSU15500" /db_xref="EnsemblGenomes-Tr:CAB13424" /db_xref="GOA:P25995" /db_xref="InterPro:IPR002195" /db_xref="InterPro:IPR004722" /db_xref="InterPro:IPR006680" /db_xref="InterPro:IPR011059" /db_xref="InterPro:IPR032466" /db_xref="SubtiList:BG10714" /db_xref="UniProtKB/Swiss-Prot:P25995" /translation="MSYLIKNGWILNENGEKTQADIRVTGETITAIGKLDATDNETVI DAKGLLVSPGFVDLHVHFREPGGEKKETIETGAKAAARGGYTTVAAMPNTRPVPDTKE QMEWVQNRIKETSCVRVLPYASITIRQIGDEMTNFEALKEAGAFAFTDDGVGIQTAGM MYEAMKRAAAIDKAIVAHCEDNSLIYGGSVHEGTFSKANGLNGIPSVCESVHIARDVL LAEAANCHYHVCHISTKESVRVVRDAKKAGIRVTAEVSPHHLLLCDEDIPGLDTNYKM NPPLRSPEDRAALIEGLLDGTIDFIATDHAPHTEEEKNTEMKLAPFGIVGLETAFPLL YTHFVKNGSWSLKQLIDYMTIKPCEAFGLPYGTLQTGQAADITLIDLEKEAVIDKETF LSKGKNTPFNGISCTGWPVATIAAGKLAYEEGRLVK*" /label="pyrC CDS" gene 1533702..1534988 /gene="pyrC" /locus_tag="BSU_15500" /old_locus_tag="BSU15500" /label="pyrC gene" CDS 1534985..1536079 /gene="pyrAA" /locus_tag="BSU_15510" /old_locus_tag="BSU15510" /EC_number="6.3.5.5" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 1709162, 11390694, 23750951; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyrimidine-specific carbamoyl-phosphate synthetase (small subunit, glutaminase subunit)" /protein_id="NP_389434.1" /db_xref="EnsemblGenomes-Gn:BSU15510" /db_xref="EnsemblGenomes-Tr:CAB13425" /db_xref="GOA:P25993" /db_xref="InterPro:IPR002474" /db_xref="InterPro:IPR006274" /db_xref="InterPro:IPR017926" /db_xref="InterPro:IPR029062" /db_xref="InterPro:IPR035686" /db_xref="InterPro:IPR036480" /db_xref="SubtiList:BG10715" /db_xref="UniProtKB/Swiss-Prot:P25993" /translation="MKRRLVLENGAVFEGEAFGSLEHNMGEVVFNTGMTGYQEILSDP SYCGQIVTLTYPLIGNYGINRDDFESITPFVKGLIIKELCELPSNWRSAYTLDEYLKM KNIPGLQGIDTRKLTRMIRTAGALKGTFASSDEDIEAVLKRLNETELPRNQVSQVSAK TAYPSPGRGKRIVLVDFGMKHGILRELNKRKCDVIVVPYNITAEEVLQLKPDGIMLSN GPGDPKDVPEAIEMIKGVLGKVPLFGICLGHQLFALACGANTEKMKFGHRGSNHPVKE LATGKVALTSQNHGYTVSSISKTELEVTHIAINDDTIEGLKHKTLPAFTVQYHPEASP GPEDANHLFDRFIEMIETTEKEGEAVCQNA*" /label="pyrAA CDS" gene 1534985..1536079 /gene="pyrAA" /locus_tag="BSU_15510" /old_locus_tag="BSU15510" /label="pyrAA gene" CDS 1536064..1539279 /gene="pyrAB" /locus_tag="BSU_15520" /old_locus_tag="BSU15520" /EC_number="6.3.5.5" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 216664, 6120161, 10732707, 23750951; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyrimidine-specific carbamoyl-phosphate synthetase (large subunit)" /protein_id="NP_389435.1" /db_xref="EnsemblGenomes-Gn:BSU15520" /db_xref="EnsemblGenomes-Tr:CAB13426" /db_xref="GOA:P25994" /db_xref="InterPro:IPR005479" /db_xref="InterPro:IPR005480" /db_xref="InterPro:IPR005483" /db_xref="InterPro:IPR006275" /db_xref="InterPro:IPR011607" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="InterPro:IPR033937" /db_xref="InterPro:IPR036897" /db_xref="InterPro:IPR036914" /db_xref="SubtiList:BG10716" /db_xref="UniProtKB/Swiss-Prot:P25994" /translation="MPKRVDINKILVIGSGPIIIGQAAEFDYAGTQACLALKEEGYEV ILVNSNPATIMTDTEMADRVYIEPLTPEFLTRIIRKERPDAILPTLGGQTGLNLAVEL SERGVLAECGVEVLGTKLSAIQQAEDRDLFRTLMNELNEPVPESEIIHSLEEAEKFVS QIGFPVIVRPAYTLGGTGGGICSNETELKEIVENGLKLSPVHQCLLEKSIAGYKEIEY EVMRDSQDHAIVVCNMENIDPVGIHTGDSIVVAPSQTLSDREYQLLRNVSLKLIRALG IEGGCNVQLALDPDSFQYYIIEVNPRVSRSSALASKATGYPIAKLAAKIAVGLSLDEM MNPVTGKTYAAFEPALDYVVSKIPRWPFDKFESANRKLGTQMKATGEVMAIGRTLEES LLKAVRSLEADVYHLELKDAADISDELLEKRIKKAGDERLFYLAEAYRRGYTVEDLHE FSAIDVFFLHKLFGIVQFEKELKANAGDTDVLRRAKELGFSDQYISREWKMKESELYS LRKQAGIAPVFKMVDTCAAEFESETPYFYSTYEEENESVVTDKKSVMVLGSGPIRIGQ GVEFDYATVHSVWAIKQAGYEAIIVNNNPETVSTDFSISDKLYFEPLTIEDVMHIIDL EQPMGVVVQFGGQTAINLADELSARGVKILGTSLEDLDRAEDRDKFEQALGELGVPQP LGKTATSVNQAVSIASDIGYPVLVRPSYVLGGRAMEIVYHEEELLHYMKNAVKINPQH PVLIDRYLTGKEIEVDAVSDGETVVIPGIMEHIERAGVHSGDSIAVYPPQSLTEDIKK KIEQYTIALAKGLNIVGLLNIQFVLSQGEVYVLEVNPRSSRTVPFLSKITGIPMANLA TKIILGQKLAAFGYTEGLQPEQQGVFVKAPVFSFAKLRRVDITLGPEMKSTGEVMGKD STLEKALYKALIASGIQIPNYGSVLLTVADKDKEEGLAIAKRFHAIGYNILATEGTAG YLKEASIPAKVVGKIGQDGPNLLDVIRNGEAQFVINTLTKGKQPARDGFRIRRESVEN GVACLTSLDTAEAILRVLESMTFRADQMPAVNTNQEAAVTI*" /label="pyrAB CDS" gene 1536064..1539279 /gene="pyrAB" /locus_tag="BSU_15520" /old_locus_tag="BSU15520" /label="pyrAB gene" CDS 1539276..1540046 /gene="pyrK" /locus_tag="BSU_15530" /old_locus_tag="BSU15530" /EC_number="1.3.98.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:169225, 10545205, 11188687, 15299876" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 169225, 10545205, 11188687, 15299876; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydroorotate dehydrogenase (electron transfer subunit)" /protein_id="NP_389436.1" /db_xref="EnsemblGenomes-Gn:BSU15530" /db_xref="EnsemblGenomes-Tr:CAB13427" /db_xref="GOA:P25983" /db_xref="InterPro:IPR001433" /db_xref="InterPro:IPR012165" /db_xref="InterPro:IPR017927" /db_xref="InterPro:IPR017938" /db_xref="InterPro:IPR019480" /db_xref="InterPro:IPR023455" /db_xref="InterPro:IPR037117" /db_xref="SubtiList:BG10717" /db_xref="UniProtKB/Swiss-Prot:P25983" /translation="MKKAYLTVCSNQQIADRVFQMVLKGELVQGFTTPGQFLHLKVSE AVTPLLRRPISIADVNFEKNEVTIIYRVDGEGTRLLSLKQQGELVDVLGPLGNGFPVN EVQPGKTALLVGGGVGVPPLQELSKRLIEKGVNVIHVLGFQSAKDVFYEEECRQYGDT YVATADGSYGETGFVTDVIKRKKLEFDILLSCGPTPMLKALKQEYAHKEVYLSMEERM GCGIGACFACVCHTNESETSYVKVCLDGPVFKAQEVAL*" /label="pyrK CDS" gene 1539276..1540046 /gene="pyrK" /locus_tag="BSU_15530" /old_locus_tag="BSU15530" /label="pyrK gene" CDS 1540046..1540981 /gene="pyrD" /locus_tag="BSU_15540" /old_locus_tag="BSU15540" /EC_number="1.3.1.15" /experiment="publication(s) with functional evidences, PMID:4380263, 10545205" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4380263, 10545205; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydroorotate dehydrogenase (catalytic subunit)" /protein_id="NP_389437.1" /db_xref="EnsemblGenomes-Gn:BSU15540" /db_xref="EnsemblGenomes-Tr:CAB13428" /db_xref="GOA:P25996" /db_xref="InterPro:IPR001295" /db_xref="InterPro:IPR005720" /db_xref="InterPro:IPR012135" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR024920" /db_xref="InterPro:IPR033888" /db_xref="SubtiList:BG10718" /db_xref="UniProtKB/Swiss-Prot:P25996" /translation="MLEVKLPGLDLKNPIIPASGCFGFGKEFSRFYDLSCLGAIMIKA TTKEPRFGNPTPRVAETGAGMLNAIGLQNPGLDSVLHHELPWLEQFDTPIIANVAGSQ VDDYVEVAEHISKAPNVHALELNISCPNVKTGGIAFGTNPEMAADLTKAVKEVSDVPV YVKLSPNVANITEIALAIEEAGADGLTMINTLIGMRLDLKTGKPILANKTGGLSGPAV KPVAIRMVYEVSQMVNIPIIGMGGVQTAEDALEFLLAGASAVAVGTANFVNPFACPEI IEQLPSVLLQYGYQSIEECIGRSWNHEKQPAHHRA*" /label="pyrD CDS" gene 1540046..1540981 /gene="pyrD" /locus_tag="BSU_15540" /old_locus_tag="BSU15540" /label="pyrD gene" CDS 1540950..1541669 /gene="pyrF" /locus_tag="BSU_15550" /old_locus_tag="BSU15550" /EC_number="4.1.1.23" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10681442, 11390694, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10681442, 11390694, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="orotidine 5'-phosphate decarboxylase" /protein_id="NP_389438.1" /db_xref="EnsemblGenomes-Gn:BSU15550" /db_xref="EnsemblGenomes-Tr:CAB13429" /db_xref="GOA:P25971" /db_xref="InterPro:IPR001754" /db_xref="InterPro:IPR011060" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR014732" /db_xref="InterPro:IPR018089" /db_xref="PDB:1DBT" /db_xref="SubtiList:BG10719" /db_xref="UniProtKB/Swiss-Prot:P25971" /translation="MKNNLPIIALDFASAEETLAFLAPFQQEPLFVKVGMELFYQEGP SIVKQLKERNCELFLDLKLHDIPTTVNKAMKRLASLGVDLVNVHAAGGKKMMQAALEG LEEGTPAGKKRPSLIAVTQLTSTSEQIMKDELLIEKSLIDTVVHYSKQAEESGLDGVV CSVHEAKAIYQAVSPSFLTVTPGIRMSEDAANDQVRVATPAIAREKGSSAIVVGRSIT KAEDPVKAYKAVRLEWEGIKS*" /label="pyrF CDS" gene 1540950..1541669 /gene="pyrF" /locus_tag="BSU_15550" /old_locus_tag="BSU15550" /label="pyrF gene" CDS 1541648..1542298 /gene="pyrE" /locus_tag="BSU_15560" /old_locus_tag="BSU15560" /EC_number="2.4.2.10" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9305779, 22447609, 23405251; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="orotate phosphoribosyltransferase" /protein_id="NP_389439.1" /db_xref="EnsemblGenomes-Gn:BSU15560" /db_xref="EnsemblGenomes-Tr:CAB13430" /db_xref="GOA:P25972" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR004467" /db_xref="InterPro:IPR023031" /db_xref="InterPro:IPR029057" /db_xref="SubtiList:BG10720" /db_xref="UniProtKB/Swiss-Prot:P25972" /translation="MGGNQILKQIIAKHLLDIQAVFLRPNEPFTWASGILSPIYCDNR LTLSFPEVRNDVASGISKLVKEHFPEAEMIAGTATAGIPHAALAADHLNLPMCYVRSK PKAHGKGNQIEGAVQEGQKTVVIEDLISTGGSVLEACAALQAAGCEVLGVVSIFTYGL PKAEEAFAKAELPYYSLTDYDTLTEVALENGNIHSDDLKKLQTWKRNPESKDWFKK*" /label="pyrE CDS" gene 1541648..1542298 /gene="pyrE" /locus_tag="BSU_15560" /old_locus_tag="BSU15560" /label="pyrE gene" downshifts 1542300 /Source="Nicolas_upshifts" /id="D874" /incds=0 /nref=17 /ntot=184 /MaxReadThrough="3.91018" /MaxDrop="5.49939" /score="33.4515727" /energy="-9" /TU="U1287,U1288" /idTUdmin="U1287" /TUdmin="-115" /isTUend="FALSE" /label="downshifts" S_feature 1542345..1542417 /Source="Nicolas_S_feature" /locus_tag="new_1630017_1630089" /HighExp="Cold, Gly, MG 5, S0, LPh, M/G, GM 60, MG t5, Mal, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S568" promotor_-35 1542397..1542404 /Source="Nicolas_upshift_promotors" /id="U1289" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig=1 /xcortree=2889 /SigmaFactorBS="tgaggcctgtttttttattaatcctataaaaaaagtcgGGTT GACTtatgttagaattgTGCTAAAATTTACTACAAATctaaaaacttatcaagagcgg c" /listShort="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1542418..1542437 /Source="Nicolas_upshift_promotors" /id="U1289" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig=1 /xcortree=2889 /SigmaFactorBS="tgaggcctgtttttttattaatcctataaaaaaagtcgGGTT GACTtatgttagaattgTGCTAAAATTTACTACAAATctaaaaacttatcaagagcgg c" /listShort="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1542419 /Source="Nicolas_upshifts" /id="U1289" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig=1 /xcortree=2889 /SigmaFactorBS="tgaggcctgtttttttattaatcctataaaaaaagtcgGGTT GACTtatgttagaattgTGCTAAAATTTACTACAAATctaaaaacttatcaagagcgg c" /listShort="NA, S569, cysH, cysP, sat, cysC, S570, sumT, sirB, sirC" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 1542443..1542548 /gene="mswE" /locus_tag="BSU_misc_RNA_29" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762; Product type n: RNA" /label="mswE RNA" gene 1542443..1542548 /gene="mswE" /locus_tag="BSU_misc_RNA_29" /label="mswE gene" S_feature 1542549..1542709 /Source="Nicolas_S_feature" /locus_tag="new_1630221_1630381" /HighExp="MG 10, B60, MG 5, MG t5, M9-exp, MG 25, MG 60, MG 15, GM 90, GM 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S569" CDS 1542710..1543411 /gene="cysH" /locus_tag="BSU_15570" /old_locus_tag="BSU15570" /EC_number="1.8.4.8" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10094622, 11004190, 12072441, 16267287, 18456801" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 11004190, 12072441, 16267287, 18456801; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="(phospho)adenosine phosphosulfate reductase" /protein_id="NP_389440.1" /db_xref="EnsemblGenomes-Gn:BSU15570" /db_xref="EnsemblGenomes-Tr:CAB13431" /db_xref="GOA:P94498" /db_xref="InterPro:IPR002500" /db_xref="InterPro:IPR004511" /db_xref="InterPro:IPR011798" /db_xref="InterPro:IPR014729" /db_xref="SubtiList:BG11930" /db_xref="UniProtKB/Swiss-Prot:P94498" /translation="MLTYDNWEEPTITFPEDDPYKGALSVLKWAYGHYGDQLVYACSF GIEGIVLIDLIYKVKKDAEIVFLDTGLHFKETYETIERVKERYPGLNIILKKPDLTLE EQAEEHGDKLWEREPNQCCYLRKVVPLREALSGHPAWLSGLRRDQGPSRANTNFLNKD EKFKSVKVCPLIHWTWKDIWRYTSRNELDYNPLHDQGYPSIGCAPCTSPAFTAEDLRS GRWNGMAKTECGLHE*" /label="cysH CDS" gene 1542710..1543411 /gene="cysH" /locus_tag="BSU_15570" /old_locus_tag="BSU15570" /label="cysH gene" CDS 1543423..1544487 /gene="cysP" /locus_tag="BSU_15580" /old_locus_tag="BSU15580" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10094622, 10784039, 11004190, 15849754, 16850406, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 10784039, 11004190, 15849754, 16850406, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="sulfate permease" /protein_id="NP_389441.1" /db_xref="EnsemblGenomes-Gn:BSU15580" /db_xref="EnsemblGenomes-Tr:CAB13432" /db_xref="GOA:O34734" /db_xref="InterPro:IPR001204" /db_xref="SubtiList:BG13377" /db_xref="UniProtKB/Swiss-Prot:O34734" /translation="MELAAILFSLFFAMNIGASGAAASMGVAYGSGAIKKKTYALILC AVGVFAGAVIGGGEVVKTISSGIIPEQTITLTIVCIIIGAAALSLFTANLLGIPLSTS EVTVGAVVGVGVAYKVLFVNNLLIIVSFWVFVPLFAFGFTYFVSKLFRYFKIEVKSSK KQKILGIVLLVAGFFEAFSAGMNNVANAVGPLVAAGVLDVGKGTLYGGAFVALGALLL GRRVLETNGKKITRFSKGEGILLSGTGAGLVIISSVFGMPVPLAQVTSSSIIGIGMAK NGPNVFHKQVVQTMLKVWIVSPFLSLSISYLLVSLFLKADYYSIFIMVSVLLAAGGAI SLTKAIRKERRSVHEQGGGI*" /label="cysP CDS" gene 1543423..1544487 /gene="cysP" /locus_tag="BSU_15580" /old_locus_tag="BSU15580" /label="cysP gene" CDS 1544536..1545684 /gene="sat" /locus_tag="BSU_15590" /old_locus_tag="BSU15590" /EC_number="2.7.7.4" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10094622, 11004190, 11274114; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sulfate adenylyltransferase" /protein_id="NP_389442.1" /db_xref="EnsemblGenomes-Gn:BSU15590" /db_xref="EnsemblGenomes-Tr:CAB13433" /db_xref="GOA:O34764" /db_xref="InterPro:IPR002650" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR020792" /db_xref="InterPro:IPR024951" /db_xref="InterPro:IPR025980" /db_xref="SubtiList:BG13378" /db_xref="UniProtKB/Swiss-Prot:O34764" /translation="MSLAPHGGTLVNRVDESYDVSGIQKEIELDLISFADLELIGIGA YSPIEGFFNEKDYVSVVENMRLSSGVVWSLPITLPVDAQKAAELSLGETVKLTYEGET YGVIQIEDLYVPDKQKEAVNVYKTDEQEHPGVKKLFSRGNTYVGGPITLIKKASKQFP EFTFEPSETRRQFAEKGWETIVGFQTRNPVHRAHEYIQKTALETVDGLFLNPLVGETK SDDIPADVRMESYQVLLDHYYPKDRVFLGVFLAAMRYAGPREAIFHALVRKNYGCTHF IVGRDHAGVGDYYGTYEAQELFDTFKPEELGITPLKFEHSFFCKKCGNMGTAKTCPHG REHHVILSGTKVRGMLRDGVLPPAEFSRKEVVEVLIKGMKKKEEVGVS*" /label="sat CDS" gene 1544536..1545684 /gene="sat" /locus_tag="BSU_15590" /old_locus_tag="BSU15590" /label="sat gene" upshifts complement(1544625) /Source="Nicolas_upshifts" /id="U1290" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.978021978021978" /psig="0.007992007992008" /xcortree=27 /SigmaFactorBS="accttcaatcgggctgtatgcaccgATaccgatcaattccaa atCCGCGaaagaaattaaatcaagttcaatttctttttgaatgccgctcacatcatat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1544637..1544641) /Source="Nicolas_upshift_promotors" /id="U1290" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.978021978021978" /psig="0.007992007992008" /xcortree=27 /SigmaFactorBS="accttcaatcgggctgtatgcaccgATaccgatcaattccaa atCCGCGaaagaaattaaatcaagttcaatttctttttgaatgccgctcacatcatat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1544659..1544660) /Source="Nicolas_upshift_promotors" /id="U1290" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.978021978021978" /psig="0.007992007992008" /xcortree=27 /SigmaFactorBS="accttcaatcgggctgtatgcaccgATaccgatcaattccaa atCCGCGaaagaaattaaatcaagttcaatttctttttgaatgccgctcacatcatat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1545697..1546290 /gene="cysC" /locus_tag="BSU_15600" /old_locus_tag="BSU15600" /EC_number="2.7.1.25" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1332767, 10094622, 11004190, 19067028, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="adenylylsulfate kinase" /protein_id="NP_389443.1" /db_xref="EnsemblGenomes-Gn:BSU15600" /db_xref="EnsemblGenomes-Tr:CAB13434" /db_xref="GOA:O34577" /db_xref="InterPro:IPR002891" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13379" /db_xref="UniProtKB/Swiss-Prot:O34577" /translation="MTNRDIVWHEASITKEEYQQKNKHKSSILWLTGLSGSGKSTIAN AAARELFEQGYQVIVLDGDNIRHGLNRDLGFSDEDRKENIRRIGEVAKLFVQQGTIVI TAFISPFREDRQQVRELVEAGEFNEVYIKCDLDICEQRDPKGLYKKARNGEIPFFTGI DSPYEEPEAPELVLDSGQHDREACKNQLIEFVKQKLS*" /label="cysC CDS" gene 1545697..1546290 /gene="cysC" /locus_tag="BSU_15600" /old_locus_tag="BSU15600" /label="cysC gene" S_feature 1546291..1546388 /Source="Nicolas_S_feature" /locus_tag="new_1633963_1634060" /HighExp="MG 10, B36, MG 5, MG t5, B60, MG 15, MG 90, MG-0.2, MG 60, MG 45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S570" CDS 1546389..1547162 /gene="sumT" /locus_tag="BSU_15610" /old_locus_tag="BSU15610" /EC_number="2.1.1.107" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 1906874, 11004190, 10094622, 19154787; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="uroporphyrinogen III and precorrin-1 C-methyltransferase" /protein_id="NP_389444.1" /db_xref="EnsemblGenomes-Gn:BSU15610" /db_xref="EnsemblGenomes-Tr:CAB13435" /db_xref="GOA:O34744" /db_xref="InterPro:IPR000878" /db_xref="InterPro:IPR003043" /db_xref="InterPro:IPR006366" /db_xref="InterPro:IPR014776" /db_xref="InterPro:IPR014777" /db_xref="InterPro:IPR035996" /db_xref="SubtiList:BG13380" /db_xref="UniProtKB/Swiss-Prot:O34744" /translation="MGKVYIVGAGPGDPDLLTIKALKAIEKADVILYDRLVNKEILQY AKEQADLIYCGKLPDFHTMKQETINRFLVKYAQKGKMVVRLKGGDPFVFGRGGEEAEC LSENGIPFEIIPGITSGIAAAAYAGIPVTHRDAGSNVAFVTGHYKKEEDFEEKWKALA TGIDTLVIYMGIKNVQQIERKLLENGRDGSTPAAFIHWGTTDKQKSVFCTVDTLSETV IKENITNPSLIVIGNVVNYHYKLEWFESELKKQDLSEAL*" /label="sumT CDS" gene 1546389..1547162 /gene="sumT" /locus_tag="BSU_15610" /old_locus_tag="BSU15610" /label="sumT gene" promotor_-35 1547067..1547074 /Source="Nicolas_upshift_promotors" /id="U1291" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.763236763236763" /psig=1 /xcortree=1738 /SigmaFactorBS="ttcagaaacggtgataaaagaaaacattacaaatccgAGTTT AATtgtcattggaaatgTTGTAAATTATCACTATAAGctggaatggtttgaatctgaa c" /listShort="sirB, sirC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1547089..1547108 /Source="Nicolas_upshift_promotors" /id="U1291" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.763236763236763" /psig=1 /xcortree=1738 /SigmaFactorBS="ttcagaaacggtgataaaagaaaacattacaaatccgAGTTT AATtgtcattggaaatgTTGTAAATTATCACTATAAGctggaatggtttgaatctgaa c" /listShort="sirB, sirC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1547090 /Source="Nicolas_upshifts" /id="U1291" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.763236763236763" /psig=1 /xcortree=1738 /SigmaFactorBS="ttcagaaacggtgataaaagaaaacattacaaatccgAGTTT AATtgtcattggaaatgTTGTAAATTATCACTATAAGctggaatggtttgaatctgaa c" /listShort="sirB, sirC" /GFF_Attribute="listLong" /label="upshifts" CDS 1547165..1547950 /gene="sirB" /locus_tag="BSU_15620" /old_locus_tag="BSU15620" /EC_number="4.99.1.4" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 10094622, 11004190, 12408752; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sirohydrochlorin ferrochelatase" /protein_id="NP_389445.1" /db_xref="EnsemblGenomes-Gn:BSU15620" /db_xref="EnsemblGenomes-Tr:CAB13436" /db_xref="GOA:O34632" /db_xref="InterPro:IPR002762" /db_xref="SubtiList:BG13381" /db_xref="UniProtKB/Swiss-Prot:O34632" /translation="MKQAILYVGHGSRVKKAQQEAAAFLEGCKAHISVPVQEISFLEL QEPTIETGFEACVKQGATHIAVVPLLLLTAAHAKHDIPEEIVRVASRYPSVRISYGKP IGIDEEVVKAVYHRMKDIGVPYENARVVLIGRGSSDPDVKRDVTGIANLLQEMVPVKE VIPCFLTACGPNYKEVFSELEKDDGITTFIVPYLLFTGMLMNEIEREVQKLKAHNPNV YLSSYIGFHPHVKNAFLNRVRETAANSEGQFDFDGGSYASAAH*" /label="sirB CDS" gene 1547165..1547950 /gene="sirB" /locus_tag="BSU_15620" /old_locus_tag="BSU15620" /label="sirB gene" CDS 1547931..1548419 /gene="sirC" /locus_tag="BSU_15630" /old_locus_tag="BSU15630" /EC_number="1.3.1.76" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 10094622, 11004190, 12408752, 18588505; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="precorrin-2 dehydrogenase" /protein_id="NP_389446.1" /db_xref="EnsemblGenomes-Gn:BSU15630" /db_xref="EnsemblGenomes-Tr:CAB13437" /db_xref="GOA:O34813" /db_xref="InterPro:IPR006367" /db_xref="InterPro:IPR028161" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13382" /db_xref="UniProtKB/Swiss-Prot:O34813" /translation="MLPLHISLEKKKVVIAGGGSIALRRLKTVISEGADITLVSPDVE PEIKQMAEERRIKWEKRTIEKEDYLNAFFIIAATDNAAVNKEIAQSASPFQLVNCVSD AELGNVYMPKIVKRGHVTVSVSTSGASPKHTKELAENVDKLIDGDFVAEVNRLYQMRR KK*" /label="sirC CDS" gene 1547931..1548419 /gene="sirC" /locus_tag="BSU_15630" /old_locus_tag="BSU15630" /label="sirC gene" downshifts 1548399 /Source="Nicolas_upshifts" /id="D875" /incds=0 /nref=256 /ntot=267 /MaxReadThrough="2.85828" /MaxDrop="8.90139" /score="26.5923498" /energy="-16.6" /TU="U1289" /idTUdmin="U1291" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1548446) /Source="Nicolas_upshifts" /id="D876" /incds=0 /nref=149 /ntot=238 /MaxReadThrough="1.71588" /MaxDrop="5.36964" /score="15.559144" /energy="-16.6" /TU="NA" /idTUdmin="U1292" /TUdmin=7 /isTUend="TRUE" /label="downshifts" CDS complement(1548459..1550177) /gene="fbnA" /locus_tag="BSU_15640" /old_locus_tag="BSU15640" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 11238985, 17586671, 24646681, 28294433; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative tRNA modification protein" /protein_id="NP_389447.1" /db_xref="EnsemblGenomes-Gn:BSU15640" /db_xref="EnsemblGenomes-Tr:CAB13438" /db_xref="InterPro:IPR008532" /db_xref="SubtiList:BG13383" /db_xref="UniProtKB/Swiss-Prot:O34693" /translation="MHMSFDGMFTYGMTHELNEKIMGGRITKIHQPYKHDVIFHIRAK GKNQKLLLSAHPSYSRVHITAQAYENPSEPPMFCMLLRKHIEGGFIEKIEQAGLDRIM IFHIKSRNEIGDETVRKLYVEIMGRHSNIILTDAAENVIIDGLKHLSPSMNSYRTVLP GQDYKLPPAQDKISPLEASEDDILRHLSFQEGRLDKQIVDHFSGVSPLFAKEAVHRAG LANKVTLPKALLALFAEVKEHRFIPNITTVNGKEYFYLLELTHLKGEARRFDSLSELL DRFYFGKAERDRVKQQAQDLERFVVNERKKNANKIKKLEKTLEYSENAKEFQLYGELL TANLYMLKKGDKQAEVINYYDEESPTITIPLNPNKTPSENAQAYFTKYQKAKNSVAVV EEQIRLAQEEIEYFDQLIQQLSSASPRDISEIREELVEGKYLRPKQQKGQKKQKPHNP VLETYESTSGLTILVGKNNRQNEYLTTRVAARDDIWLHTKDIPGSHVVIRSSEPDEQT IMEAATIAAYFSKAKDSSSVPVDYTKIRHVKKPNGAKPGFVTYDSQHTVFVTPDADTV IKLKKS*" /label="fbnA CDS" gene complement(1548459..1550177) /gene="fbnA" /locus_tag="BSU_15640" /old_locus_tag="BSU15640" /label="fbnA gene" promotor_-10 complement(1550199..1550218) /Source="Nicolas_upshift_promotors" /id="U1292" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.766233766233766" /psig="0.999000999001" /xcortree=2006 /SigmaFactorBS="gctctcttatagagatatcactctataagcatgcttaTTCTG ActcgtcccatttCATGCTATAATTATCGAATGcaggaagaatgagagggtgtattgc a" /listShort="yloA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 1550213..1550218 /Source="Nicolas_upshift_promotors" /id="U1293" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=989 /SigmaFactorBS="tacaccctctcattcttcctgcattcgataattatAGCATGa aatgggacgagtcaGAATAAGCATGCTTATAGAgtgatatctctataagagagcaggg g" /listShort="yloB, S571, yloC, ylzA, gmk, rpoZ" /listLong="coaBC" /label="promotor_-35" upshifts complement(1550213) /Source="Nicolas_upshifts" /id="U1292" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.766233766233766" /psig="0.999000999001" /xcortree=2006 /SigmaFactorBS="gctctcttatagagatatcactctataagcatgcttaTTCTG ActcgtcccatttCATGCTATAATTATCGAATGcaggaagaatgagagggtgtattgc a" /listShort="yloA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1550231..1550236) /Source="Nicolas_upshift_promotors" /id="U1292" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.766233766233766" /psig="0.999000999001" /xcortree=2006 /SigmaFactorBS="gctctcttatagagatatcactctataagcatgcttaTTCTG ActcgtcccatttCATGCTATAATTATCGAATGcaggaagaatgagagggtgtattgc a" /listShort="yloA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1550234..1550252 /Source="Nicolas_upshift_promotors" /id="U1293" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=989 /SigmaFactorBS="tacaccctctcattcttcctgcattcgataattatAGCATGa aatgggacgagtcaGAATAAGCATGCTTATAGAgtgatatctctataagagagcaggg g" /listShort="yloB, S571, yloC, ylzA, gmk, rpoZ" /listLong="coaBC" /label="promotor_-10" upshifts 1550238 /Source="Nicolas_upshifts" /id="U1293" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=989 /SigmaFactorBS="tacaccctctcattcttcctgcattcgataattatAGCATGa aatgggacgagtcaGAATAAGCATGCTTATAGAgtgatatctctataagagagcaggg g" /listShort="yloB, S571, yloC, ylzA, gmk, rpoZ" /listLong="coaBC" /label="upshifts" CDS 1550293..1552965 /gene="tcaB" /locus_tag="BSU_15650" /old_locus_tag="BSU15650" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12161109, 24415722" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12161109, 24415722; Product type t: transporter" /codon_start=1 /transl_table=11 /product="P-type calcium transport ATPase (sporulation)" /protein_id="NP_389448.1" /db_xref="EnsemblGenomes-Gn:BSU15650" /db_xref="EnsemblGenomes-Tr:CAB13439" /db_xref="GOA:O34431" /db_xref="InterPro:IPR001757" /db_xref="InterPro:IPR004014" /db_xref="InterPro:IPR005782" /db_xref="InterPro:IPR006068" /db_xref="InterPro:IPR008250" /db_xref="InterPro:IPR018303" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR023298" /db_xref="InterPro:IPR023299" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG13384" /db_xref="UniProtKB/Swiss-Prot:O34431" /translation="MKFHEMGQTDLLEATNTSMKQGLTEKEVKKRLDKHGPNELQEGK KTSALLLFFAQFKDFMVLVLLAATLISGFLGEYVDAVAIIAIVFVNGILGFFQERRAE QSLQALKELSTPHVMALREGSWTKIPSKELVPGDIVKFTSGDRIGADVRIVEARSLEI EESALTGESIPVVKHADKLKKPDVSLGDITNMAFMGTIVTRGSGVGVVVGTGMNTAMG KIADMLESAGTLSTPLQRRLEQLGKILIVVALLLTVLVVAVGVIQGHDLYSMFLAGVS LAVAAIPEGLPAIVTVALSLGVQRMIKQKSIVRKLPAVETLGCASIICSDKTGTMTQN KMTVTHVWSGGKTWRVAGAGYEPKGSFTLNEKEISVNEHKPLQQMLLFGALCNNSNIE KRDGEYVLDGDPTEGALLTAARKGGFSKEFVESNYRVIEEFPFDSARKMMTVIVENQD RKRYIITKGAPDVLMQRSSRIYYDGSAALFSNERKAETEAVLRHLASQALRTIAVAYR PIKAGETPSMEQAEKDLTMLGLSGIIDPPRPEVRQAIKECREAGIKTVMITGDHVETA KAIAKDLRLLPKSGKIMDGKMLNELSQEELSHVVEDVYVFARVSPEHKLKIVKAYQEN GHIVAMTGDGVNDAPAIKQADIGVSMGITGTDVAKEASSLVLVDDNFATIKSAIKEGR NIYENIRKFIRYLLASNVGEILVMLFAMLLALPLPLVPIQILWVNLVTDGLPAMALGM DQPEGDVMKRKPRHPKEGVFARKLGWKVVSRGFLIGVATILAFIIVYHRNPENLAYAQ TIAFATLVLAQLIHVFDCRSETSVFSRNPFQNLYLIGAVLSSILLMLVVIYYPPLQPI FHTVAITPGDWMLVIGMSAIPTFLLAGSLLTRKK*" /label="tcaB CDS" gene 1550293..1552965 /gene="tcaB" /locus_tag="BSU_15650" /old_locus_tag="BSU15650" /label="tcaB gene" promotor_-10 complement(1551698..1551717) /Source="Nicolas_upshift_promotors" /id="U1294" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.914085914085914" /psig="0.98001998001998" /xcortree=1702 /SigmaFactorBS="ttaataccgcctctgtttctgcttttctttCATTTGAAaaaa gagccgctgaGCCATCATAATAAATACGGGaagatcgctgcatgagtacatccggcgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1551709) /Source="Nicolas_upshifts" /id="U1294" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.914085914085914" /psig="0.98001998001998" /xcortree=1702 /SigmaFactorBS="ttaataccgcctctgtttctgcttttctttCATTTGAAaaaa gagccgctgaGCCATCATAATAAATACGGGaagatcgctgcatgagtacatccggcgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1551732..1551739) /Source="Nicolas_upshift_promotors" /id="U1294" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.914085914085914" /psig="0.98001998001998" /xcortree=1702 /SigmaFactorBS="ttaataccgcctctgtttctgcttttctttCATTTGAAaaaa gagccgctgaGCCATCATAATAAATACGGGaagatcgctgcatgagtacatccggcgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 1552971..1552990 /Source="Nicolas_upshift_promotors" /id="U1295" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.925074925074925" /psig="0.994005994005994" /xcortree=2170 /SigmaFactorBS="cgccatccctacttttttgctggcggggtcacttttaacaag aaaaaaataaattcaTATGATATAATCTTAGGGGTaatagcgtgtctattgccctttt a" /listShort="S571, yloC, ylzA, gmk, rpoZ, coaBC, priA, defA, fmt, rsmB, yloN, prpC, prkC, cpgA, rpe, thiN, S573, spoVM" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 1552974..1553047 /Source="Nicolas_S_feature" /locus_tag="new_1640646_1640719" /HighExp="LPhT, LBGstat, T3.0H, H2O2, T3.30H, Salt, B60, Lbexp, UNK1, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="0.994, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S571" upshifts 1552974 /Source="Nicolas_upshifts" /id="U1295" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.925074925074925" /psig="0.994005994005994" /xcortree=2170 /SigmaFactorBS="cgccatccctacttttttgctggcggggtcacttttaacaag aaaaaaataaattcaTATGATATAATCTTAGGGGTaatagcgtgtctattgccctttt a" /listShort="S571, yloC, ylzA, gmk, rpoZ, coaBC, priA, defA, fmt, rsmB, yloN, prpC, prkC, cpgA, rpe, thiN, S573, spoVM" /GFF_Attribute="listLong" /label="upshifts" CDS 1553048..1553923 /gene="yloC" /locus_tag="BSU_15660" /old_locus_tag="BSU15660" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389449.1" /db_xref="EnsemblGenomes-Gn:BSU15660" /db_xref="EnsemblGenomes-Tr:CAB13440" /db_xref="InterPro:IPR005229" /db_xref="InterPro:IPR013527" /db_xref="InterPro:IPR013551" /db_xref="SubtiList:BG13385" /db_xref="UniProtKB/Swiss-Prot:O34441" /translation="MIRSMTGFGSASKTQDDLSVSVELKSVNYRFKEVNARLPRPLLY FEDKLKQTILQHIQRGRIELFVSVDSDMLVEKRLEIDWPLLDEFVAAARDMKKRYQLS AEPDVMDFFKLDHVVQVHEEQTQNDKLEALIIDAAEEAVKGLCEMREKEGLLLAKDCL MHIDQLEELVRETELLAADVVSRYRERLYARIKEWTEDVLDESRLVTECAIFADRSDI TEEITRLKSHFAQFRDILASGGAVGRKLDFLVQELNREANTIGSKANDHQITKLVVEM KSSIEKIKEQVQNIE*" /label="yloC CDS" gene 1553048..1553923 /gene="yloC" /locus_tag="BSU_15660" /old_locus_tag="BSU15660" /label="yloC gene" CDS 1554000..1554269 /gene="remA" /locus_tag="BSU_15670" /old_locus_tag="BSU15670" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:19363116, 23396918, 23646920" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19363116, 23396918, 23646920; Product type r: regulator" /codon_start=1 /transl_table=11 /product="essential sporulation DNA binding protein; regulator of biofilm formation" /protein_id="NP_570902.1" /db_xref="EnsemblGenomes-Gn:BSU15670" /db_xref="EnsemblGenomes-Tr:CAE01452" /db_xref="InterPro:IPR007169" /db_xref="SubtiList:BG14185" /db_xref="UniProtKB/Swiss-Prot:Q7WY72" /translation="MTIKLINIGFGNIISANRMISIVSPESAPIKRMIQDARDRGMLI DATYGRRTRAVVVMDSDHIILSAVQPETVAHRLSVKEEIMDEGQG*" /label="remA CDS" gene 1554000..1554269 /gene="remA" /locus_tag="BSU_15670" /old_locus_tag="BSU15670" /label="remA gene" misc_feature complement(1554080..1554084) /Source="Nicolas_upshift_promotors" /id="U1296" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.889110889110889" /psig="0.001998001998002" /xcortree=58 /SigmaFactorBS="ccgtatgtagcgtcaattagcattccgcggtctcttgcatcc tgaatcatccgtttgattgGCGCAgactccgggctgacaatcgaaatcatccgattgg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1554085) /Source="Nicolas_upshifts" /id="U1296" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.889110889110889" /psig="0.001998001998002" /xcortree=58 /SigmaFactorBS="ccgtatgtagcgtcaattagcattccgcggtctcttgcatcc tgaatcatccgtttgattgGCGCAgactccgggctgacaatcgaaatcatccgattgg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 1554277..1554891 /gene="gmk" /locus_tag="BSU_15680" /old_locus_tag="BSU15680" /EC_number="2.7.4.8" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 17012781, 24722991" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17012781, 24722991; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="guanylate kinase" /protein_id="NP_389450.2" /db_xref="EnsemblGenomes-Gn:BSU15680" /db_xref="EnsemblGenomes-Tr:CAB13441" /db_xref="GOA:O34328" /db_xref="InterPro:IPR008144" /db_xref="InterPro:IPR008145" /db_xref="InterPro:IPR017665" /db_xref="InterPro:IPR020590" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13386" /db_xref="UniProtKB/Swiss-Prot:O34328" /translation="MKERGLLIVLSGPSGVGKGTVRQAIFSQEDTKFEYSISVTTRSP REGEVNGVDYFFKTRDEFEQMIADNKLLEWAEYVGNYYGTPVDYVEQTLQDGKDVFLE IEVQGALQVRNAFPEGLFIFLAPPSLSELKNRIVTRGTETDALIENRMKAAKAEIEMM DAYDYVVENDNVETACDKIKAIVLAEHLKRERVAPRYKKMLEVE*" /label="gmk CDS" gene 1554277..1554891 /gene="gmk" /locus_tag="BSU_15680" /old_locus_tag="BSU15680" /label="gmk gene" CDS 1554895..1555098 /gene="rpoZ" /locus_tag="BSU_15690" /old_locus_tag="BSU15690" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12089032, 16159791, 17233676, 24476911, 25878038; Product type f: factor" /codon_start=1 /transl_table=11 /product="omega subunit of RNA polymerase" /protein_id="NP_389451.1" /db_xref="EnsemblGenomes-Gn:BSU15690" /db_xref="EnsemblGenomes-Tr:CAB13442" /db_xref="GOA:O35011" /db_xref="InterPro:IPR003716" /db_xref="InterPro:IPR006110" /db_xref="InterPro:IPR012293" /db_xref="InterPro:IPR036161" /db_xref="SubtiList:BG13387" /db_xref="UniProtKB/Swiss-Prot:O35011" /translation="MLDPSIDSLMNKLDSKYTLVTVSARRAREMQIKKDQMIEHTISH KYVGKALEEIDAGLLSFEKEDRE*" /label="rpoZ CDS" gene 1554895..1555098 /gene="rpoZ" /locus_tag="BSU_15690" /old_locus_tag="BSU15690" /label="rpoZ gene" downshifts 1555087 /Source="Nicolas_upshifts" /id="D877" /incds=0 /nref=118 /ntot=257 /MaxReadThrough="5.65143" /MaxDrop="4.7291" /score="-8.13961715" /energy="-7.7" /TU="U1293,U1295" /idTUdmin="U1293" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" CDS 1555179..1556399 /gene="coaBC" /locus_tag="BSU_15700" /old_locus_tag="BSU15700" /EC_number="4.1.1.36" /EC_number="6.3.2.5" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11278255, 11358972, 12140293, 14686929, 15530362; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="coenzyme A biosynthesis bifunctional protein CoaBC; phosphopantothenoylcysteine synthetase/decarboxylase" /protein_id="NP_389452.1" /db_xref="EnsemblGenomes-Gn:BSU15700" /db_xref="EnsemblGenomes-Tr:CAB13443" /db_xref="GOA:O35033" /db_xref="InterPro:IPR003382" /db_xref="InterPro:IPR005252" /db_xref="InterPro:IPR007085" /db_xref="InterPro:IPR035929" /db_xref="InterPro:IPR036551" /db_xref="SubtiList:BG13388" /db_xref="UniProtKB/Swiss-Prot:O35033" /translation="MLNNRNVLLCVSGGIAVYKACALTSKLVQAGANVKVIMTESACR FVSPLTFQALSRHEVYTDTFKEQNPSVISHIDAADWADLIIVAPATANVIGKLANGIA DDMLTTTLLAATAPVWIAPAMNVHMYDHPAVKRNISVLYQDGYCFIEPSEGYLACGYV GKGRLEEPENIVKLAEKHFAEETSAPLEGKHVVITAGPTREAIDPVRFFTNKSTGKMG YALAEAAVQLGARVILISGPVSLDQPKGLAEFIPVQSAADMREAVLSVYDASDIVIKT AAVADFTPKTVFDHKMKKQDGGMTLELKRTVDILKELGEKKKEQILVGFAAETQDIEH YARKKLAAKNLDLIVANDVKANGAGFGADTNIVTIFFKDGHKRELPIMSKLDVSFEIL QEIAALSKQTGERS*" /label="coaBC CDS" gene 1555179..1556399 /gene="coaBC" /locus_tag="BSU_15700" /old_locus_tag="BSU15700" /label="coaBC gene" S_feature complement(1556238..1556813) /Source="Nicolas_S_feature" /locus_tag="new_1643910_1644485_c" /HighExp="Etha, Salt, Sw, Gly, C30, M9-stat, B60, LPhT, HiTm, Heat" /AntisenseName="priA" /AntisenseCor="-5.1213364637925501E-2" /AntisenseRegPval="-0.4" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S572" CDS 1556396..1558813 /gene="priA" /locus_tag="BSU_15710" /old_locus_tag="BSU15710" /function="16.9: Replicate" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10572298, 11917020, 12682299, 21170359, 22720735, 28527403" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10572298, 11917020, 12682299, 21170359, 22720735, 28527403; Product type f : factor" /codon_start=1 /transl_table=11 /product="primosomal replication factor Y (primosomal protein N')" /protein_id="NP_389453.1" /db_xref="EnsemblGenomes-Gn:BSU15710" /db_xref="EnsemblGenomes-Tr:CAB13444" /db_xref="GOA:P94461" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR005259" /db_xref="InterPro:IPR006935" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11963" /db_xref="UniProtKB/Swiss-Prot:P94461" /translation="MNFAEVIVDVSTKNIDRPFDYKIPDHLKGMIKTGMRVIVPFGPR KIQGFVTAVKEASDLSGKSVKEVEDLLDLTPVLTEELMILSSWLSDKTLSFKITALQA MLPAALKAKYEKELKIAHGADLPPQVERLFSETKTLLYSDIPDHETLKLIQRHVQKGD IDVTYKVAQKTNKKMVRHIQANASKEELAKQAEGLSRQAAKQQAILHFLISEPEGVKI PAAELCKKTDTSSATIKTLIQKGLLKESYEEVYRDPYQDKMFKKTEPLPLTDEQRAAF EPIRETLDSDEHKVFLLHGVTGSGKTEIYLQSIEKVLAKGKEAIVLVPEISLTPQMVN RFKGRFGSQVAVMHSGLSTGEKYDEWRKIHRKEVRLVVGARSAIFAPFENLGMIIIDE EHESSYKQEEMPRYHAKEVAIKRAEHHSCPVVLGSATPTLESYARAQKGVYELLSLKH RVNHRVMPEVSLVDMREELRNGNRSMFSVELMEKLEETIAKGEQAVLFLNKRGYSSFV MCRDCGYVPQCPHCDISMTYHRYGQRLKCHYCGHEEPVPHTCPECASEHIRFFGTGTQ RVEEELTKVLPSARVIRMDVDTTSRKGAHEKLLSAFGEGKADILLGTQMIAKGLDFPN VTLVGVLSADTTLHIPDFRSAEKTFQLLTQVSGRAGRHEKPGHVIIQTYTPSHYSIQL TKTHDYETFYQHEMAHRREQSYPPYYYLALVTVSHEEVAKAAVTAEKIAHFLKANCGA DTKILGPSASPIARIKDRYRYQCVIKYKQETQLSALLKKILEHYKREIEQKHVMISID MNPYMMM*" /label="priA CDS" gene 1556396..1558813 /gene="priA" /locus_tag="BSU_15710" /old_locus_tag="BSU15710" /label="priA gene" promotor_-10 complement(1556809..1556827) /Source="Nicolas_upshift_promotors" /id="U1297" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=253 /SigmaFactorBS="cccctttttgaacatgcctttgaatcAGTTTCAgcgtctcat gatcGGGTATATCTGAATACAGCagcgtctttgtttcagaaaacagccgttccacttg c" /listShort="S572" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1556813) /Source="Nicolas_upshifts" /id="U1297" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=253 /SigmaFactorBS="cccctttttgaacatgcctttgaatcAGTTTCAgcgtctcat gatcGGGTATATCTGAATACAGCagcgtctttgtttcagaaaacagccgttccacttg c" /listShort="S572" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1556841..1556847) /Source="Nicolas_upshift_promotors" /id="U1297" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=253 /SigmaFactorBS="cccctttttgaacatgcctttgaatcAGTTTCAgcgtctcat gatcGGGTATATCTGAATACAGCagcgtctttgtttcagaaaacagccgttccacttg c" /listShort="S572" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1558664..1558668 /Source="Nicolas_upshift_promotors" /id="U1298" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=2458 /SigmaFactorBS="caagcgcgtcgccgatagccaggatcaaaGATAGatatcgct atcaatgCGTGATAAAATACAAACAGGaaacccagttatccgctttattgaagaagat a" /listShort="defA, fmt, rsmB, yloN, prpC, prkC, cpgA, rpe, thiN, S573, spoVM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1558684..1558703 /Source="Nicolas_upshift_promotors" /id="U1298" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=2458 /SigmaFactorBS="caagcgcgtcgccgatagccaggatcaaaGATAGatatcgct atcaatgCGTGATAAAATACAAACAGGaaacccagttatccgctttattgaagaagat a" /listShort="defA, fmt, rsmB, yloN, prpC, prkC, cpgA, rpe, thiN, S573, spoVM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1558695 /Source="Nicolas_upshifts" /id="U1298" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=2458 /SigmaFactorBS="caagcgcgtcgccgatagccaggatcaaaGATAGatatcgct atcaatgCGTGATAAAATACAAACAGGaaacccagttatccgctttattgaagaagat a" /listShort="defA, fmt, rsmB, yloN, prpC, prkC, cpgA, rpe, thiN, S573, spoVM" /GFF_Attribute="listLong" /label="upshifts" CDS 1558840..1559322 /gene="defA" /locus_tag="BSU_15720" /old_locus_tag="BSU15720" /EC_number="3.5.1.88" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11429456, 16014871, 16207374" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11429456, 16014871, 16207374; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peptide deformylase" /protein_id="NP_389454.1" /db_xref="EnsemblGenomes-Gn:BSU15720" /db_xref="EnsemblGenomes-Tr:CAB13445" /db_xref="GOA:P94462" /db_xref="InterPro:IPR023635" /db_xref="InterPro:IPR036821" /db_xref="SubtiList:BG11933" /db_xref="UniProtKB/Swiss-Prot:P94462" /translation="MAVKKVVTHPAEVLETPAETVTVFDKKLKKLLDDMYDTMLEMDG VGLAAPQIGILKRAAVVEIGDDRGRIDLVNPEILEKSGEQTGIEGCLSFPNVYGDVTR ADYVKVRAFNRQGKPFILEARGFLARAVQHEMDHLDGVLFTSKISKYYTEDELADMEG *" /label="defA CDS" gene 1558840..1559322 /gene="defA" /locus_tag="BSU_15720" /old_locus_tag="BSU15720" /label="defA gene" CDS 1559327..1560280 /gene="fmt" /locus_tag="BSU_15730" /old_locus_tag="BSU15730" /EC_number="2.1.2.9" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:769821, 769822, 98518, 9843487, 10858337, 26888283, 27983482" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 769821, 769822, 98518, 9843487, 10858337, 26888283, 27983482; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="methionyl-tRNA formyltransferase" /protein_id="NP_389455.1" /db_xref="EnsemblGenomes-Gn:BSU15730" /db_xref="EnsemblGenomes-Tr:CAB13446" /db_xref="GOA:P94463" /db_xref="InterPro:IPR001555" /db_xref="InterPro:IPR002376" /db_xref="InterPro:IPR005793" /db_xref="InterPro:IPR005794" /db_xref="InterPro:IPR011034" /db_xref="InterPro:IPR036477" /db_xref="InterPro:IPR037022" /db_xref="SubtiList:BG11937" /db_xref="UniProtKB/Swiss-Prot:P94463" /translation="MTRIVFMGTPDFSVPVLRTLIEDGYEVVGVVTQPDRPKGRKKVL TPPPVKEEALRHGIPVLQPEKVRLTEEIEKVLALKPDLIVTAAFGQILPKELLDSPKY GCINVHASLLPELRGGAPIHYSILQGKKKTGITIMYMVEKLDAGDMISKVEVDIEETD NVGTLHDKLSVAGAKLLSETVPNVIAGSISPEKQDEEKATYAPNIKREQELLDWSRTG EELYNQIRGLNPWPVAYTTLNGQNLKIWASKKIAAPTTAEPGTVVAVEKEGIIVATGN ETALLLTELQPAGKKRMKGEDFVRGAHVEAGDVLGVNNEKN*" /label="fmt CDS" gene 1559327..1560280 /gene="fmt" /locus_tag="BSU_15730" /old_locus_tag="BSU15730" /label="fmt gene" CDS 1560267..1561610 /gene="rsmB" /locus_tag="BSU_15740" /old_locus_tag="BSU15740" /EC_number="2.1.1.176" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14656444, 23729652, 27698115; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="RNA-binding Sun protein; 16S rRNA m5C967 methyltransferase, S-adenosyl-L-methionine-dependent" /protein_id="NP_389456.1" /db_xref="EnsemblGenomes-Gn:BSU15740" /db_xref="EnsemblGenomes-Tr:CAB13447" /db_xref="GOA:P94464" /db_xref="InterPro:IPR001678" /db_xref="InterPro:IPR004573" /db_xref="InterPro:IPR006027" /db_xref="InterPro:IPR018314" /db_xref="InterPro:IPR023267" /db_xref="InterPro:IPR029063" /db_xref="InterPro:IPR035926" /db_xref="SubtiList:BG12253" /db_xref="UniProtKB/Swiss-Prot:P94464" /translation="MKKTSVRDIALEALIKLEQNQAYSNLLLKSVIKSNELSDQNRGL LTELVYGTLQNKIALDYMLKPFINKPQKVKPWVIQLLRLSLYQMEYLEKIPDRAAIHE AVEIAKIRGHKGIASFVNGVLRSIQREGVPSFDAIEDPVRRLATETSHPEWLVKEWAD AYGFEAAEKICRIHLIPPKQTLRVNQMKADRAELLDQMAAEGIEVEKGDLAEDAVKLL KGTIAGTHFFQNGEVSIQDESSMLVARALDPKSDETVLDACAAPGGKSAHIAELMKNK GSVTSLDLHKHKVKLIKEAADRLGLTIIHAETMDARKAGETFENEQFDRILVDAPCSG FGVIRRKPDMKYTKKPDDSARLAEIQLSILREIAPLVKKGGTLVYSTCTMDRTENDEV IHAFIQEHPDFEPDLSLEKRLPEKVRPFVRDGRLQILPHYFGTDGFFICSMRKKG*" /label="rsmB CDS" gene 1560267..1561610 /gene="rsmB" /locus_tag="BSU_15740" /old_locus_tag="BSU15740" /label="rsmB gene" CDS 1561614..1562705 /gene="rlmN" /locus_tag="BSU_15750" /old_locus_tag="BSU15750" /EC_number="2.1.1.192" /function="10.3: tRNA and rRNA base modification" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8973346, 18307109, 20184321, 21368151, 22891362, 27081063, 27902775; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="23S rRNA m2A2503 methyltransferase and tRNA A37 C2 methyltransferase" /protein_id="NP_389457.1" /db_xref="EnsemblGenomes-Gn:BSU15750" /db_xref="EnsemblGenomes-Tr:CAB13448" /db_xref="GOA:O34617" /db_xref="InterPro:IPR004383" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR027492" /db_xref="SubtiList:BG13389" /db_xref="UniProtKB/Swiss-Prot:O34617" /translation="MAELNKTKVRKELRTERPSIYSFELDEIKQWLTDNGEKPFRAAQ IFEWLYEKRVSSFEDMTNLSKDLREKLNTRFVLTTLKTAVKQTSQDGTMKFLFELHDG YTIETVLMRHEYGNSVCVTTQVGCRIGCTFCASTLGGLKRNLEAGEIVAQVVKVQKAL DETDERVSSVVIMGIGEPFDNFNEMLAFLKIINHDKGLNIGARHITVSTSGIIPKIYE FADQQMQINFAISLHAPNTEIRSRLMPINRAYKLPDLMEAVKYYINKTGRRISFEYGL FGGVNDQVEHAEELADLLEGVKCHVNLIPVNYVPERDYVRTPRDQIFAFEKTLKSRGV NVTIRREQGHDIDAACGQLRAKERQDETR*" /label="rlmN CDS" gene 1561614..1562705 /gene="rlmN" /locus_tag="BSU_15750" /old_locus_tag="BSU15750" /label="rlmN gene" CDS 1562712..1563476 /gene="prpC" /locus_tag="BSU_15760" /old_locus_tag="BSU15760" /EC_number="3.1.3.16" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10986276, 12399479, 17693724, 22720735, 24390483, 25012659" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10986276, 12399479, 17693724, 22720735, 24390483, 25012659; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="multitarget phosphorylated protein phosphatase" /protein_id="NP_389458.1" /db_xref="EnsemblGenomes-Gn:BSU15760" /db_xref="EnsemblGenomes-Tr:CAB13449" /db_xref="GOA:O34779" /db_xref="InterPro:IPR001932" /db_xref="InterPro:IPR015655" /db_xref="InterPro:IPR036457" /db_xref="SubtiList:BG13390" /db_xref="UniProtKB/Swiss-Prot:O34779" /translation="MLTALKTDTGKIRQHNEDDAGIFKGKDEFILAVVADGMGGHLAG DVASKMAVKAMGEKWNEAETIPTAPSECEKWLIEQILSVNSKIYDHAQAHEECQGMGT TIVCALFTGKTVSVAHIGDSRCYLLQDDDFVQVTEDHSLVNELVRTGEISREDAEHHP RKNVLTKALGTDQLVSIDTRSFDIEPGDKLLLCSDGLTNKVEGTELKDILQSDSAPQE KVNLLVDKANQNGGEDNITAVLLELALQVEEGEDQC*" /label="prpC CDS" gene 1562712..1563476 /gene="prpC" /locus_tag="BSU_15760" /old_locus_tag="BSU15760" /label="prpC gene" downshifts 1562765 /Source="Nicolas_upshifts" /id="D878" /incds=0 /nref=5 /ntot=126 /MaxReadThrough="6.12318" /MaxDrop="3.8594" /score="-7.80200272" /energy="-10" /TU="U1295,U1298" /idTUdmin="U1300" /TUdmin="-4708" /isTUend="FALSE" /label="downshifts" CDS 1563470..1565416 /gene="prkC" /locus_tag="BSU_15770" /old_locus_tag="BSU15770" /EC_number="2.7.11.1" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:10986276, 12399479, 18984160, 24390483, 25845974, 26102633" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10986276, 12399479, 18984160, 24390483, 25845974, 26102633; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="protein serine/threonine kinase" /protein_id="NP_389459.1" /db_xref="EnsemblGenomes-Gn:BSU15770" /db_xref="EnsemblGenomes-Tr:CAB13450" /db_xref="GOA:O34507" /db_xref="InterPro:IPR000719" /db_xref="InterPro:IPR005543" /db_xref="InterPro:IPR008271" /db_xref="InterPro:IPR011009" /db_xref="InterPro:IPR017441" /db_xref="SubtiList:BG13391" /db_xref="UniProtKB/Swiss-Prot:O34507" /translation="MLIGKRISGRYQILRVIGGGGMANVYLAEDIILDREVAIKILRF DYANDNEFIRRFRREAQSASSLDHPNIVSIYDLGEEDDIYYIVMEYVEGMTLKEYITA NGPLHPKEALNIMEQIVSAIAHAHQNQIVHRDIKPHNILIDHMGNIKVTDFGIATALS STTITHTNSVLGSVHYLSPEQARGGLATKKSDIYALGIVLFELLTGRIPFDGESAVSI ALKHLQAETPSAKRWNPSVPQSVENIILKATAKDPFHRYETAEDMEADIKTAFDADRL NEKRFTIQEDEEMTKAIPIIKDEELAKAAGEKEAEVTTAQENKTKKNGKRKKWPWVLL TICLVFITAGILAVTVFPSLFMPKDVKIPDVSGMEYEKAAGLLEKEGLQVDSEVLEIS DEKIEEGLMVKTDPKADTTVKEGATVTLYKSTGKAKTEIGDVTGQTVDQAKKALKDQG FNHVTVNEVNDEKNAGTVIDQNPSAGTELVPSEDQVKLTVSIGPEDITLRDLKTYSKE AASGYLEDNGLKLVEKEAYSDDVPEGQVVKQKPAAGTAVKPGNEVEVTFSLGPEKKPA KTVKEKVKIPYEPENEGDELQVQIAVDDADHSISDTYEEFKIKEPTERTIELKIEPGQ KGYYQVMVNNKVVSYKTIEYPKDE*" /label="prkC CDS" gene 1563470..1565416 /gene="prkC" /locus_tag="BSU_15770" /old_locus_tag="BSU15770" /label="prkC gene" promotor_-35 1565325..1565331 /Source="Nicolas_upshift_promotors" /id="U1299" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=173 /SigmaFactorBS="cgactgaacgaacgatcgaactaaAGATTGAaccaggccaaa aaGGGTACTATCAAGTAATGGtaaacaataaagttgtcagctacaaaaccattgagta t" /listShort="cpgA, rpe, thiN, S573, spoVM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1565345..1565363 /Source="Nicolas_upshift_promotors" /id="U1299" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=173 /SigmaFactorBS="cgactgaacgaacgatcgaactaaAGATTGAaccaggccaaa aaGGGTACTATCAAGTAATGGtaaacaataaagttgtcagctacaaaaccattgagta t" /listShort="cpgA, rpe, thiN, S573, spoVM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1565361 /Source="Nicolas_upshifts" /id="U1299" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.973026973026973" /psig="0.973026973026973" /xcortree=173 /SigmaFactorBS="cgactgaacgaacgatcgaactaaAGATTGAaccaggccaaa aaGGGTACTATCAAGTAATGGtaaacaataaagttgtcagctacaaaaccattgagta t" /listShort="cpgA, rpe, thiN, S573, spoVM" /GFF_Attribute="listLong" /label="upshifts" CDS 1565431..1566327 /gene="rsgA" /locus_tag="BSU_15780" /old_locus_tag="BSU15780" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15223319, 15828870, 16014871, 16485133, 17005971, 18007041, 18344364, 19246764, 22544754, 22720735, 28482099" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15223319, 15828870, 16014871, 16485133, 17005971, 18007041, 18344364, 19246764, 22544754, 22720735, 28482099; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="GTPase involved in ribosome biogenesis" /protein_id="NP_389460.1" /db_xref="EnsemblGenomes-Gn:BSU15780" /db_xref="EnsemblGenomes-Tr:CAB13451" /db_xref="GOA:O34530" /db_xref="InterPro:IPR004881" /db_xref="InterPro:IPR010914" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030378" /db_xref="InterPro:IPR031944" /db_xref="PDB:1T9H" /db_xref="SubtiList:BG13392" /db_xref="UniProtKB/Swiss-Prot:O34530" /translation="MPEGKIIKALSGFYYVLDESEDSDKVIQCRGRGIFRKNKITPLV GDYVVYQAENDKEGYLMEIKERTNELIRPPICNVDQAVLVFSAVQPSFSTALLDRFLV LVEANDIQPIICITKMDLIEDQDTEDTIQAYAEDYRNIGYDVYLTSSKDQDSLADIIP HFQDKTTVFAGQSGVGKSSLLNAISPELGLRTNEISEHLGRGKHTTRHVELIHTSGGL VADTPGFSSLEFTDIEEEELGYTFPDIREKSSSCKFRGCLHLKEPKCAVKQAVEDGEL KQYRYDHYVEFMTEIKDRKPRY*" /label="rsgA CDS" gene 1565431..1566327 /gene="rsgA" /locus_tag="BSU_15780" /old_locus_tag="BSU15780" /label="rsgA gene" CDS 1566332..1566985 /gene="rpe" /locus_tag="BSU_15790" /old_locus_tag="BSU15790" /EC_number="5.1.3.1" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 973353, 15755726, 16489742, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribulose-5-phosphate 3-epimerase" /protein_id="NP_389461.1" /db_xref="EnsemblGenomes-Gn:BSU15790" /db_xref="EnsemblGenomes-Tr:CAB13452" /db_xref="GOA:O34557" /db_xref="InterPro:IPR000056" /db_xref="InterPro:IPR011060" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR026019" /db_xref="SubtiList:BG13393" /db_xref="UniProtKB/Swiss-Prot:O34557" /translation="MIKVAPSILSADFAALGNEIKDVEKGGADCIHIDVMDGHFVPNI TIGPLIVEAVRPVTDLPLDVHLMIEEPDRYIPAFAKAGADILSVHAEACPHLHRTIQL IKEQGVKAGVVLNPHTPVQVIEHVFDDLDLVLLMTVNPGFGGQKFIHSVLPKIKEVKR MADEKGKKDLLIEVDGGVNKETAPLVIEAGANLLVAGSAVYGQSDRKKAISEIRGSK* " /label="rpe CDS" gene 1566332..1566985 /gene="rpe" /locus_tag="BSU_15790" /old_locus_tag="BSU15790" /label="rpe gene" promotor_-35 1566983..1566992 /Source="Nicolas_upshift_promotors" /id="U1300" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.95104895104895" /psig="0.95104895104895" /xcortree=753 /SigmaFactorBS="aaaaagcaatttctgaaatcagaggaagtaaaTAAGCAGCTT tagaaaagagctgGGCATACAATAGCCTAAGCTctttttcctgtatgcagagaaagga a" /listShort="thiN" /listLong="S573, spoVM, S574, yloU, yloV" /label="promotor_-35" promotor_-10 1567006..1567025 /Source="Nicolas_upshift_promotors" /id="U1300" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.95104895104895" /psig="0.95104895104895" /xcortree=753 /SigmaFactorBS="aaaaagcaatttctgaaatcagaggaagtaaaTAAGCAGCTT tagaaaagagctgGGCATACAATAGCCTAAGCTctttttcctgtatgcagagaaagga a" /listShort="thiN" /listLong="S573, spoVM, S574, yloU, yloV" /label="promotor_-10" upshifts 1567011 /Source="Nicolas_upshifts" /id="U1300" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.95104895104895" /psig="0.95104895104895" /xcortree=753 /SigmaFactorBS="aaaaagcaatttctgaaatcagaggaagtaaaTAAGCAGCTT tagaaaagagctgGGCATACAATAGCCTAAGCTctttttcctgtatgcagagaaagga a" /listShort="thiN" /listLong="S573, spoVM, S574, yloU, yloV" /label="upshifts" CDS 1567058..1567702 /gene="thiN" /locus_tag="BSU_15800" /old_locus_tag="BSU15800" /EC_number="2.7.6.2" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14567704, 15150256, 16291685, 19490098; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thiamine pyrophosphokinase" /protein_id="NP_389462.1" /db_xref="EnsemblGenomes-Gn:BSU15800" /db_xref="EnsemblGenomes-Tr:CAB13453" /db_xref="GOA:O34664" /db_xref="InterPro:IPR006282" /db_xref="InterPro:IPR007371" /db_xref="InterPro:IPR007373" /db_xref="InterPro:IPR036371" /db_xref="InterPro:IPR036759" /db_xref="PDB:3LM8" /db_xref="SubtiList:BG13394" /db_xref="UniProtKB/Swiss-Prot:O34664" /translation="MKTINIVAGGPKNLIPDLTGYTDEHTLWIGVDKGTVTLLDAGII PVEAFGDFDSITEQERRRIEKAAPALHVYQAEKDQTDLDLALDWALEKQPDIIQIFGI TGGRADHFLGNIQLLYKGVKTNIKIRLIDKQNHIQMFPPGEYDIEKDENKRYISFIPF SEDIHELTLTGFKYPLNNCHITLGSTLCISNELIHSRGTFSFAKGILIMIRSTD*" /label="thiN CDS" gene 1567058..1567702 /gene="thiN" /locus_tag="BSU_15800" /old_locus_tag="BSU15800" /label="thiN gene" promotor_-35 1567463..1567469 /Source="Nicolas_upshift_promotors" /id="U1301" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.548451548451548" /psig="0.548451548451548" /xcortree=1059 /SigmaFactorBS="aaaaacgaacataaaaattaggctgatagacaaacaaaatca tATTCAAAtgttccctcctggtGAATATGATATTGAGAAGGatgaaaataagcgatat a" /listShort="S573, spoVM, S574" /listLong="yloU, yloV" /label="promotor_-35" upshifts 1567480 /Source="Nicolas_upshifts" /id="U1301" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.548451548451548" /psig="0.548451548451548" /xcortree=1059 /SigmaFactorBS="aaaaacgaacataaaaattaggctgatagacaaacaaaatca tATTCAAAtgttccctcctggtGAATATGATATTGAGAAGGatgaaaataagcgatat a" /listShort="S573, spoVM, S574" /listLong="yloU, yloV" /label="upshifts" promotor_-10 1567484..1567502 /Source="Nicolas_upshift_promotors" /id="U1301" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.548451548451548" /psig="0.548451548451548" /xcortree=1059 /SigmaFactorBS="aaaaacgaacataaaaattaggctgatagacaaacaaaatca tATTCAAAtgttccctcctggtGAATATGATATTGAGAAGGatgaaaataagcgatat a" /listShort="S573, spoVM, S574" /listLong="yloU, yloV" /label="promotor_-10" promotor_-35 1567593..1567598 /Source="Nicolas_upshift_promotors" /id="U1302" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=1088 /SigmaFactorBS="cggttttaaatatcctctaaataattGTCATAttacgctcgg ttcaaCACTATGTATTAGTAACGAactcattcattcacgaggtactttttcgtttgca a" /listShort="S573, spoVM, S574, yloU, yloV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1567614..1567632 /Source="Nicolas_upshift_promotors" /id="U1302" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=1088 /SigmaFactorBS="cggttttaaatatcctctaaataattGTCATAttacgctcgg ttcaaCACTATGTATTAGTAACGAactcattcattcacgaggtactttttcgtttgca a" /listShort="S573, spoVM, S574, yloU, yloV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1567627 /Source="Nicolas_upshifts" /id="U1302" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=1088 /SigmaFactorBS="cggttttaaatatcctctaaataattGTCATAttacgctcgg ttcaaCACTATGTATTAGTAACGAactcattcattcacgaggtactttttcgtttgca a" /listShort="S573, spoVM, S574, yloU, yloV" /GFF_Attribute="listLong" /label="upshifts" S_feature 1567703..1567773 /Source="Nicolas_S_feature" /locus_tag="new_1655375_1655445" /HighExp="S4, S5, S7, S8, S6, S3, B36, G/S, B60, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigEF, SigB, SigA, SigA" /TUshortPSig="0.977, 0.548, 0.973, 1, 0.994" /TUlongSig="SigK" /TUlongPSig="0.951" /label="S573" CDS 1567774..1567854 /gene="spoVM" /locus_tag="BSU_15810" /old_locus_tag="BSU15810" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:9922240, 10077851, 10913836, 12562810, 18820968, 25825747, 28408070" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9922240, 10077851, 10913836, 12562810, 18820968, 25825747, 28408070; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor required for normal spore cortex and coatsynthesis (stage V sporulation)" /protein_id="NP_389463.1" /db_xref="EnsemblGenomes-Gn:BSU15810" /db_xref="EnsemblGenomes-Tr:CAB13454" /db_xref="GOA:P37817" /db_xref="InterPro:IPR012609" /db_xref="PDB:2MVH" /db_xref="PDB:2MVJ" /db_xref="SubtiList:BG10776" /db_xref="UniProtKB/Swiss-Prot:P37817" /translation="MKFYTIKLPKFLGGIVRAMLGSFRKD*" /label="spoVM CDS" gene 1567774..1567854 /gene="spoVM" /locus_tag="BSU_15810" /old_locus_tag="BSU15810" /label="spoVM gene" downshifts 1567869 /Source="Nicolas_upshifts" /id="D879" /incds=0 /nref=178 /ntot=258 /MaxReadThrough="4.05442" /MaxDrop="7.745" /score="7.47691609" /energy="-16.9" /TU="U1301,U1302" /idTUdmin="U1295" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 1567914..1568286 /Source="Nicolas_S_feature" /locus_tag="new_1655586_1655958" /HighExp="S4, S5, T5.0H, S3, S6, S8, S7, T4.0H, LoTm, T3.30H" /AntisenseName="rpmB" /AntisenseCor="-0.40376097579549802" /AntisenseRegPval="-11.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigEF" /TUshortPSig="0.977, 0.548" /TUlongSig="SigK" /TUlongPSig="0.951" /label="S574" CDS complement(1567927..1568115) /gene="rpmB" /locus_tag="BSU_15820" /old_locus_tag="BSU15820" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 8722036; Product type f : factor" /codon_start=1 /transl_table=11 /product="ribosomal protein L28" /protein_id="NP_389464.1" /db_xref="EnsemblGenomes-Gn:BSU15820" /db_xref="EnsemblGenomes-Tr:CAB13455" /db_xref="GOA:P37807" /db_xref="InterPro:IPR001383" /db_xref="InterPro:IPR026569" /db_xref="InterPro:IPR034704" /db_xref="InterPro:IPR037147" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10777" /db_xref="UniProtKB/Swiss-Prot:P37807" /translation="MARKCVITGKKTTAGNNRSHAMNASKRTWGANLQKVRILVNGKP KKVYVSARALKSGKVERV*" /label="rpmB CDS" gene complement(1567927..1568115) /gene="rpmB" /locus_tag="BSU_15820" /old_locus_tag="BSU15820" /label="rpmB gene" downshifts complement(1567943) /Source="Nicolas_upshifts" /id="D880" /incds=0 /nref=216 /ntot=298 /MaxReadThrough="2.59598" /MaxDrop="7.48719" /score="15.2403969" /energy="-14.3" /TU="NA" /idTUdmin="U1303" /TUdmin="-20" /isTUend="TRUE" /label="downshifts" downshifts complement(1567989) /Source="Nicolas_upshifts" /id="D881" /incds=1 /nref=1 /ntot=18 /MaxReadThrough="7.6779" /MaxDrop="3.1786" /score="15.2403969" /energy="-14.3" /TU="U1303" /idTUdmin="U1303" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" S_feature complement(1568116..1568208) /Source="Nicolas_S_feature" /locus_tag="new_1655788_1655880_c" /HighExp="HPh, LPh, HiOs, LBGexp, aero, G180, GM 15, dia0, MG 25, MG t5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S575" promotor_-10 complement(1568190..1568209) /Source="Nicolas_upshift_promotors" /id="U1303" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.782217782217782" /psig=1 /xcortree=2637 /SigmaFactorBS="agatgtcaagtgaattttcttgaaagatgatgaaacaataGT TGcaaacgttttttagcTGTGGTAAATTATTTAAAGTatccatatcgaaagcatctaa g" /listShort="S575, rpmB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1568208) /Source="Nicolas_upshifts" /id="U1303" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.782217782217782" /psig=1 /xcortree=2637 /SigmaFactorBS="agatgtcaagtgaattttcttgaaagatgatgaaacaataGT TGcaaacgttttttagcTGTGGTAAATTATTTAAAGTatccatatcgaaagcatctaa g" /listShort="S575, rpmB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1568225..1568228) /Source="Nicolas_upshift_promotors" /id="U1303" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.782217782217782" /psig=1 /xcortree=2637 /SigmaFactorBS="agatgtcaagtgaattttcttgaaagatgatgaaacaataGT TGcaaacgttttttagcTGTGGTAAATTATTTAAAGTatccatatcgaaagcatctaa g" /listShort="S575, rpmB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1568259..1568266 /Source="Nicolas_upshift_promotors" /id="U1304" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.54045954045954" /psig="0.99100899100899" /xcortree=2309 /SigmaFactorBS="ctattgtttcatcatctttcaagaaaattcaCTTGACATctt gcggaaacagcAGCGCTATAGTATATGTAGaggtacggccagcgattattgcctggtc t" /listShort="yloU, yloV, S576, sdaAB, sdaAA, recG" /listLong="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /label="promotor_-35" promotor_-10 1568281..1568299 /Source="Nicolas_upshift_promotors" /id="U1304" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.54045954045954" /psig="0.99100899100899" /xcortree=2309 /SigmaFactorBS="ctattgtttcatcatctttcaagaaaattcaCTTGACATctt gcggaaacagcAGCGCTATAGTATATGTAGaggtacggccagcgattattgcctggtc t" /listShort="yloU, yloV, S576, sdaAB, sdaAA, recG" /listLong="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /label="promotor_-10" upshifts 1568288 /Source="Nicolas_upshifts" /id="U1304" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.54045954045954" /psig="0.99100899100899" /xcortree=2309 /SigmaFactorBS="ctattgtttcatcatctttcaagaaaattcaCTTGACATctt gcggaaacagcAGCGCTATAGTATATGTAGaggtacggccagcgattattgcctggtc t" /listShort="yloU, yloV, S576, sdaAB, sdaAA, recG" /listLong="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /label="upshifts" promotor_-35 1568327..1568330 /Source="Nicolas_upshift_promotors" /id="U1305" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.451548451548452" /psig="0.99100899100899" /xcortree=2326 /SigmaFactorBS="tatgtagaggtacggccagcgattattgcctggtCTTTtcat aatggaaaccATATAGTAGAATAGCTGTAActctatgcattcgaaggaggaactagtg t" /listShort="yloU, yloV, S576, sdaAB, sdaAA, recG" /listLong="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /label="promotor_-35" promotor_-10 1568345..1568364 /Source="Nicolas_upshift_promotors" /id="U1305" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.451548451548452" /psig="0.99100899100899" /xcortree=2326 /SigmaFactorBS="tatgtagaggtacggccagcgattattgcctggtCTTTtcat aatggaaaccATATAGTAGAATAGCTGTAActctatgcattcgaaggaggaactagtg t" /listShort="yloU, yloV, S576, sdaAB, sdaAA, recG" /listLong="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /label="promotor_-10" upshifts 1568353 /Source="Nicolas_upshifts" /id="U1305" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.451548451548452" /psig="0.99100899100899" /xcortree=2326 /SigmaFactorBS="tatgtagaggtacggccagcgattattgcctggtCTTTtcat aatggaaaccATATAGTAGAATAGCTGTAActctatgcattcgaaggaggaactagtg t" /listShort="yloU, yloV, S576, sdaAB, sdaAA, recG" /listLong="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /label="upshifts" CDS 1568392..1568754 /gene="yloU" /locus_tag="BSU_15830" /old_locus_tag="BSU15830" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16014871, 17114254, 24178028, 28579978; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative factor involved in malonyl-CoA synthesis" /protein_id="NP_389465.1" /db_xref="EnsemblGenomes-Gn:BSU15830" /db_xref="EnsemblGenomes-Tr:CAB13456" /db_xref="InterPro:IPR005531" /db_xref="InterPro:IPR036837" /db_xref="SubtiList:BG13395" /db_xref="UniProtKB/Swiss-Prot:O34318" /translation="MSIELRTKYGQIDISNEVIAMVAGGAAVDCYGIVGMASKNQIKD GLTEILRKENFSRGVQVRQEGEQIHIDMYIIVSYGTKISEVAHNVQTKVKYTVNQTIG LAVDSVNIYVQGVRVTNP*" /label="yloU CDS" gene 1568392..1568754 /gene="yloU" /locus_tag="BSU_15830" /old_locus_tag="BSU15830" /label="yloU gene" downshifts complement(1568605) /Source="Nicolas_upshifts" /id="D882" /incds=1 /nref=1 /ntot=143 /MaxReadThrough="1.75412" /MaxDrop="2.71497" /score="15.2403969" /energy="-14.3" /TU="NA" /idTUdmin="U1303" /TUdmin="-682" /isTUend="FALSE" /label="downshifts" CDS 1568770..1570431 /gene="yloV" /locus_tag="BSU_15840" /old_locus_tag="BSU15840" /EC_number="2.7.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16647083, 22333191, 22517742; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme structurally related to dihydroxyacetone/glyceraldehyde kinase" /protein_id="NP_389466.1" /db_xref="EnsemblGenomes-Gn:BSU15840" /db_xref="EnsemblGenomes-Tr:CAB13457" /db_xref="GOA:O34751" /db_xref="InterPro:IPR004007" /db_xref="InterPro:IPR019986" /db_xref="InterPro:IPR033470" /db_xref="InterPro:IPR036117" /db_xref="SubtiList:BG13396" /db_xref="UniProtKB/Swiss-Prot:O34751" /translation="MSIRTLDGRTFAEMILAGAQNLSQNASAVDALNVFPVPDGDTGT NMNLSMTSGAREVEQMDTDDIGKVGSALSKGLLMGARGNSGVILSQLFRGFSKNIETK KEINALEFAAALQAGVDMAYKAVMKPVEGTILTVAKDAAKKAMILAEKETDITALMTA VTEEAEASLNRTPELLPVLKEVGVVDSGGKGLLCVYEGFLASLKGETVPQKAVLPSLD DMVSAEHHKSAQSMMNTEDIEFGFCTEVMVRLDQTKREFDEGTFRQDLSQFGDSLLVI ADESLAKVHIHAEEPGNVLNYAQHYGELIKIKIENMREQHTSIISQESKPADNETPPA KQPYGIVTVAMGEGIADLFKSIGASVVIEGGQTMNPSTEDIVDAVKSVNADTVFILPN NSNIIMAANQAASVVDEQVFVIPAKTVPQGMSALLAFNPDQEAEANEANMLSAIQQVK SGQVTFSVRDTHIDGKDIKKGDFMGILNGTIIGTSENQLSAAKMLLSEMIGEDDEIVT ILYGEDASQEEAEQLEAFLSEKYEEIEVEIHNGKQPLYSYIVSAE*" /label="yloV CDS" gene 1568770..1570431 /gene="yloV" /locus_tag="BSU_15840" /old_locus_tag="BSU15840" /label="yloV gene" S_feature 1570432..1570521 /Source="Nicolas_S_feature" /locus_tag="new_1658104_1658193" /HighExp="G135, G180, G150, LBGexp, Oxctl, Paraq, dia0, LPh, Lbexp, S0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.37023200000000001" /TUshortSig="SigA, SigA" /TUshortPSig="0.991, 0.991" /TUlongSig="NA" /TUlongPSig="NA" /label="S576" promotor_-35 1570494..1570501 /Source="Nicolas_upshift_promotors" /id="U1306" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.999000999001" /xcortree=385 /SigmaFactorBS="gcttttaagtgcggcagcgctgtaacgcgccCGCTTGCCatt ttatatctgaTCAATTAGTCTAGAAGCAAAgcgctaataagctctggttcataaggag g" /listShort="sdaAB, sdaAA, recG, fapR, plsX, fabD, fabG, acpA, S577, rnc" /listLong="smc, ftsY" /label="promotor_-35" promotor_-10 1570515..1570534 /Source="Nicolas_upshift_promotors" /id="U1306" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.999000999001" /xcortree=385 /SigmaFactorBS="gcttttaagtgcggcagcgctgtaacgcgccCGCTTGCCatt ttatatctgaTCAATTAGTCTAGAAGCAAAgcgctaataagctctggttcataaggag g" /listShort="sdaAB, sdaAA, recG, fapR, plsX, fabD, fabG, acpA, S577, rnc" /listLong="smc, ftsY" /label="promotor_-10" upshifts 1570523 /Source="Nicolas_upshifts" /id="U1306" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.999000999001" /xcortree=385 /SigmaFactorBS="gcttttaagtgcggcagcgctgtaacgcgccCGCTTGCCatt ttatatctgaTCAATTAGTCTAGAAGCAAAgcgctaataagctctggttcataaggag g" /listShort="sdaAB, sdaAA, recG, fapR, plsX, fabD, fabG, acpA, S577, rnc" /listLong="smc, ftsY" /label="upshifts" CDS 1570570..1571232 /gene="sdaAB" /locus_tag="BSU_15850" /old_locus_tag="BSU15850" /EC_number="4.3.1.17" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8385012, 9244285, 16014871, 22686449" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8385012, 9244285, 16014871, 22686449; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-serine dehydratase (beta chain)" /protein_id="NP_389467.1" /db_xref="EnsemblGenomes-Gn:BSU15850" /db_xref="EnsemblGenomes-Tr:CAB13458" /db_xref="GOA:O34635" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR004643" /db_xref="InterPro:IPR005131" /db_xref="InterPro:IPR029009" /db_xref="SubtiList:BG13397" /db_xref="UniProtKB/Swiss-Prot:O34635" /translation="MKYRSVFDIIGPVMIGPSSSHTAGAARIGRVARSLFGREPERII VSFYGSFAETYKGHGTDVAIIGGLLDFDTFDERIKTAIQIAEAKGIDIEFRVEDAVPV HPNTAKITISDEKGELELTGISIGGGKIEITELNGFELRLSGNHPAILVVHNDKFGTI AGVANVLAKFSINVGHMEVARKDIGQLALMTIEVDQNIDDHILDELSKLPNIIQVTKI AD*" /label="sdaAB CDS" gene 1570570..1571232 /gene="sdaAB" /locus_tag="BSU_15850" /old_locus_tag="BSU15850" /label="sdaAB gene" CDS 1571258..1572160 /gene="sdaAA" /locus_tag="BSU_15860" /old_locus_tag="BSU15860" /EC_number="4.3.1.17" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:2504697, 16014871, 22686449" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2504697, 16014871, 22686449; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-serine dehydratase (alpha chain)" /protein_id="NP_389468.1" /db_xref="EnsemblGenomes-Gn:BSU15860" /db_xref="EnsemblGenomes-Tr:CAB13459" /db_xref="GOA:O34607" /db_xref="InterPro:IPR004642" /db_xref="InterPro:IPR005130" /db_xref="SubtiList:BG13398" /db_xref="UniProtKB/Swiss-Prot:O34607" /translation="MFRNVKELIEITKEKQILISDVMIAQEMEVTEKTKEDIFQQMDH NLSVMEAAVQKGLEGVTSQTGLTGGDAVKLQAYIRSGKSLSGPLILDAVSKAVATNEV NAAMGTICATPTAGSAGVVPGTLFAVKEKLNPTREQMIRFLFTAGAFGFVVANNASIS GAAGGCQAEVGSASGMAAAAIVEMAGGTPEQSAEAMAITLKNMLGLVCDPVAGLVEVP CVKRNAMGASNAMIAADMALAGITSRIPCDEVIDAMYKIGQTMPTALRETGQGGLAAT PTGRELEKKIFGGALGSRETTSAN*" /label="sdaAA CDS" gene 1571258..1572160 /gene="sdaAA" /locus_tag="BSU_15860" /old_locus_tag="BSU15860" /label="sdaAA gene" CDS 1572138..1574186 /gene="recG" /locus_tag="BSU_15870" /old_locus_tag="BSU15870" /EC_number="3.6.4.12" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:1905712, 1494351, 15317759, 15533834, 16014871, 28078722, 28155219, 28527403" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1905712, 1494351, 15317759, 15533834, 16014871, 28078722, 28155219, 28527403; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="branch migrating ATP-dependent DNA helicase involved in DNA recombination and repair" /protein_id="NP_389469.1" /db_xref="EnsemblGenomes-Gn:BSU15870" /db_xref="EnsemblGenomes-Tr:CAB13460" /db_xref="GOA:O34942" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR004609" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR033454" /db_xref="SubtiList:BG13399" /db_xref="UniProtKB/Swiss-Prot:O34942" /translation="MKQHQQTSIANIKGIGPETEKTLNELGIYDISDLLNYFPYRYDD YELRDLEEVKHDERVTVEGKVHSEPSLTYYGKKRNRLTFRLLVGHYLITAVCFNRPYL KKKLSLGSVVTVSGKWDKHRQTISVQELKNGPHQEDKSIEPVYSVKENVTVKMMRRFI QQALTQYADSLPDPLPEKLRKSYKLPDYYQALKAMHQPETREALKLARRRFVYEEFLL FQLKMQAFRKAEREQTQGIRQRFSNEELMRFIKSLPFPLTNAQSRVLREITADMSSPY RMNRLLQGDVGSGKTAVAAIALYAAILSGYQGALMVPTEILAEQHADSLVSLFEKWDV SVALLTSSVKGKRRKELLERLAAGEIDILVGTHALIQDEVEFKALSLVITDEQHRFGV EQRKKLRNKGQDPDVLFMTATPIPRTLAITVFGEMDVSVIDEMPAGRKRIETYWVKHD MLDRILAFVEKELKQGRQAYIICPLIEESDKLDVQNAIDVYNMLSDIFRGKWNVGLMH GKLHSDEKDQVMREFSANHCQILVSTTVVEVGVNVPNATIMVIYDADRFGLSQLHQLR GRVGRGEHQSFCILMADPKSETGKERMRIMSETNDGFELSEKDLELRGPGDFFGKKQS GMPEFKVADMVHDYRALETARQDAANLVASDAFWKEPEYAVLRDELLKSGVMDGEKLS *" /label="recG CDS" gene 1572138..1574186 /gene="recG" /locus_tag="BSU_15870" /old_locus_tag="BSU15870" /label="recG gene" promotor_-35 1574222..1574229 /Source="Nicolas_upshift_promotors" /id="U1307" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.522477522477522" /psig=1 /xcortree=2187 /SigmaFactorBS="tcagaagtttttggtgttcagccagaaacaatCGTTGCATtc caatctatgaaaTTATATACTACTATTAGTACctagtcttaattgtccggatggtgtt t" /listShort="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1574244..1574263 /Source="Nicolas_upshift_promotors" /id="U1307" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.522477522477522" /psig=1 /xcortree=2187 /SigmaFactorBS="tcagaagtttttggtgttcagccagaaacaatCGTTGCATtc caatctatgaaaTTATATACTACTATTAGTACctagtcttaattgtccggatggtgtt t" /listShort="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1574250 /Source="Nicolas_upshifts" /id="U1307" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.522477522477522" /psig=1 /xcortree=2187 /SigmaFactorBS="tcagaagtttttggtgttcagccagaaacaatCGTTGCATtc caatctatgaaaTTATATACTACTATTAGTACctagtcttaattgtccggatggtgtt t" /listShort="fapR, plsX, fabD, fabG, acpA, S577, rnc, smc, ftsY" /GFF_Attribute="listLong" /label="upshifts" CDS 1574295..1574861 /gene="fapR" /locus_tag="BSU_15880" /old_locus_tag="BSU15880" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12737802, 17962296, 20201588, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12737802, 17962296, 20201588, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcription factor controlling fatty acid and phospholipid metabolism (FapR-malonyl-Coa)" /protein_id="NP_389470.1" /db_xref="EnsemblGenomes-Gn:BSU15880" /db_xref="EnsemblGenomes-Tr:CAB13461" /db_xref="GOA:O34835" /db_xref="InterPro:IPR006683" /db_xref="InterPro:IPR017275" /db_xref="InterPro:IPR029069" /db_xref="InterPro:IPR036388" /db_xref="PDB:2F3X" /db_xref="PDB:2F41" /db_xref="SubtiList:BG13400" /db_xref="UniProtKB/Swiss-Prot:O34835" /translation="MRRNKRERQELLQQTIQATPFITDEELAGKFGVSIQTIRLDRLE LSIPELRERIKNVAEKTLEDEVKSLSLDEVIGEIIDLELDDQAISILEIKQEHVFSRN QIARGHHLFAQANSLAVAVIDDELALTASADIRFTRQVKQGERVVAKAKVTAVEKEKG RTVVEVNSYVGEEIVFSGRFDMYRSKHS*" /label="fapR CDS" gene 1574295..1574861 /gene="fapR" /locus_tag="BSU_15880" /old_locus_tag="BSU15880" /label="fapR gene" CDS 1574875..1575876 /gene="plsX" /locus_tag="BSU_15890" /old_locus_tag="BSU15890" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8759840, 12682299, 16949372, 17557823, 17645809, 18369234, 19282621, 19850612, 24224907, 26816052, 26850107" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8759840, 12682299, 16949372, 17557823, 17645809, 18369234, 19282621, 19850612, 24224907, 26816052, 26850107; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="phosphate:acyl-ACP acyltransferase" /protein_id="NP_389471.1" /db_xref="EnsemblGenomes-Gn:BSU15890" /db_xref="EnsemblGenomes-Tr:CAB13462" /db_xref="GOA:P71018" /db_xref="InterPro:IPR003664" /db_xref="InterPro:IPR012281" /db_xref="PDB:1VI1" /db_xref="SubtiList:BG11843" /db_xref="UniProtKB/Swiss-Prot:P71018" /translation="MRIAVDAMGGDHAPKAVIDGVIKGIEAFDDLHITLVGDKTTIES HLTTTSDRITVLHADEVIEPTDEPVRAVRRKKNSSMVLMAQEVAENRADACISAGNTG ALMTAGLFIVGRIKGIDRPALAPTLPTVSGDGFLLLDVGANVDAKPEHLVQYAIMGSV YSQQVRGVTSPRVGLLNVGTEDKKGNELTKQTFQILKETANINFIGNVEARDLLDDVA DVVVTDGFTGNVTLKTLEGSALSIFKMMRDVMTSTLTSKLAAAVLKPKLKEMKMKMEY SNYGGASLFGLKAPVIKAHGSSDSNAVFHAIRQAREMVSQNVAALIQEEVKEEKTDE* " /label="plsX CDS" gene 1574875..1575876 /gene="plsX" /locus_tag="BSU_15890" /old_locus_tag="BSU15890" /label="plsX gene" CDS 1575895..1576848 /gene="fabD" /locus_tag="BSU_15900" /old_locus_tag="BSU15900" /EC_number="2.3.1.39" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14586097, 19850612" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14586097, 19850612; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="malonyl CoA:acyl carrier protein transacylase" /protein_id="NP_389472.1" /db_xref="EnsemblGenomes-Gn:BSU15900" /db_xref="EnsemblGenomes-Tr:CAB13463" /db_xref="GOA:P71019" /db_xref="InterPro:IPR004410" /db_xref="InterPro:IPR014043" /db_xref="InterPro:IPR016035" /db_xref="InterPro:IPR016036" /db_xref="InterPro:IPR020801" /db_xref="InterPro:IPR024925" /db_xref="SubtiList:BG11836" /db_xref="UniProtKB/Swiss-Prot:P71019" /translation="MSKIAFLFPGQGSQFIGMGKELYEQVPAAKRLFDEADETLETKL SSLIFEGDAEELTLTYNAQPALLTTSIAVLEKFKESGITPDFTAGHSLGEYSALVAAG ALSFKDAVYTVRKRGEFMNEAVPAGEGAMAAILGMDAEALKQVTDKVTEEGNLVQLAN LNCPGQIVISGTAKGVELASELAKENGAKRAIPLEVSGPFHSELMKPAAEKLKEVLDA CDIKDADVPVISNVSADVMTEKADIKEKLIEQLYSPVRFEESINKLIAEGVTTFIEIG PGKVLSGLVKKVNRRLKTIAVSDPETIELAIQTLKEENDNA*" /label="fabD CDS" gene 1575895..1576848 /gene="fabD" /locus_tag="BSU_15900" /old_locus_tag="BSU15900" /label="fabD gene" CDS 1576841..1577581 /gene="fabG" /locus_tag="BSU_15910" /old_locus_tag="BSU15910" /EC_number="1.1.1.100" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8759840, 12655455, 12682299, 19850612, 28126742" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8759840, 12655455, 12682299, 19850612, 28126742; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="beta-ketoacyl-acyl carrier protein reductase" /protein_id="NP_389473.1" /db_xref="EnsemblGenomes-Gn:BSU15910" /db_xref="EnsemblGenomes-Tr:CAB13464" /db_xref="GOA:P51831" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR011284" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11535" /db_xref="UniProtKB/Swiss-Prot:P51831" /translation="MLNDKTAIVTGASRGIGRSIALDLAKSGANVVVNYSGNEAKANE VVDEIKSMGRKAIAVKADVSNPEDVQNMIKETLSVFSTIDILVNNAGITRDNLIMRMK EDEWDDVININLKGVFNCTKAVTRQMMKQRSGRIINVSSIVGVSGNPGQANYVAAKAG VIGLTKSSAKELASRNITVNAIAPGFISTDMTDKLAKDVQDEMLKQIPLARFGEPSDV SSVVTFLASEGARYMTGQTLHIDGGMVM*" /label="fabG CDS" gene 1576841..1577581 /gene="fabG" /locus_tag="BSU_15910" /old_locus_tag="BSU15910" /label="fabG gene" promotor_-35 1577612..1577616 /Source="Nicolas_upshift_promotors" /id="U1308" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=2635 /SigmaFactorBS="tgtaagttttttctcgaaaatttcatcgtagtttcTCTAGtt ttttaaaaacgaaTCCACTATAATACTTGAGGGgaggtgaattgctatggcagacaca t" /listShort="acpA, S577, rnc, smc, ftsY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1577632..1577651 /Source="Nicolas_upshift_promotors" /id="U1308" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=2635 /SigmaFactorBS="tgtaagttttttctcgaaaatttcatcgtagtttcTCTAGtt ttttaaaaacgaaTCCACTATAATACTTGAGGGgaggtgaattgctatggcagacaca t" /listShort="acpA, S577, rnc, smc, ftsY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1577637 /Source="Nicolas_upshifts" /id="U1308" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=2635 /SigmaFactorBS="tgtaagttttttctcgaaaatttcatcgtagtttcTCTAGtt ttttaaaaacgaaTCCACTATAATACTTGAGGGgaggtgaattgctatggcagacaca t" /listShort="acpA, S577, rnc, smc, ftsY" /GFF_Attribute="listLong" /label="upshifts" CDS 1577665..1577898 /gene="acpA" /locus_tag="BSU_15920" /old_locus_tag="BSU15920" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8759840, 12682299, 19850612, 27467752" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8759840, 12682299, 19850612, 27467752; Product type c: carrier" /codon_start=1 /transl_table=11 /product="acyl carrier protein" /protein_id="NP_389474.1" /db_xref="EnsemblGenomes-Gn:BSU15920" /db_xref="EnsemblGenomes-Tr:CAB13465" /db_xref="GOA:P80643" /db_xref="InterPro:IPR003231" /db_xref="InterPro:IPR006162" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR036736" /db_xref="PDB:1F80" /db_xref="PDB:1HY8" /db_xref="PDB:2X2B" /db_xref="SubtiList:BG11536" /db_xref="UniProtKB/Swiss-Prot:P80643" /translation="MADTLERVTKIIVDRLGVDEADVKLEASFKEDLGADSLDVVELV MELEDEFDMEISDEDAEKIATVGDAVNYIQNQQ*" /label="acpA CDS" gene 1577665..1577898 /gene="acpA" /locus_tag="BSU_15920" /old_locus_tag="BSU15920" /label="acpA gene" downshifts 1577879 /Source="Nicolas_upshifts" /id="D883" /incds=0 /nref=22 /ntot=197 /MaxReadThrough="8.12206" /MaxDrop="4.1545" /score="-8.42930766" /energy="-17.4" /TU="U1306,U1307,U1308" /idTUdmin="U1306" /TUdmin="-880" /isTUend="FALSE" /label="downshifts" promotor_no_box 1577907..1578007 /Source="Nicolas_upshift_promotors" /id="U1309" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.502497502497502" /psig="0.030969030969031" /xcortree=1637 /SigmaFactorBS="taaaagtcccgccgaaacgcggggctttagccctttattcgt gcagttattacagcatgccgcttttacgcgcgctgtatccggtttagtcagagaagcg c" /listShort="S577, rnc, smc, ftsY" /GFF_Attribute="listLong" /label="promotor_no_box" S_feature 1577967..1578037 /Source="Nicolas_S_feature" /locus_tag="new_1665639_1665709" /HighExp="LBGstat, dia5, Cold, LBGtran, C30, Diami, G135, LBGexp, G/S, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, SigA, SigA" /TUshortPSig="0.031, 1, 1, 0.999" /TUlongSig="SigA, SigA" /TUlongPSig="0.991, 0.991" /label="S577" upshifts 1577967 /Source="Nicolas_upshifts" /id="U1309" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.502497502497502" /psig="0.030969030969031" /xcortree=1637 /SigmaFactorBS="taaaagtcccgccgaaacgcggggctttagccctttattcgt gcagttattacagcatgccgcttttacgcgcgctgtatccggtttagtcagagaagcg c" /listShort="S577, rnc, smc, ftsY" /GFF_Attribute="listLong" /label="upshifts" CDS 1578038..1578787 /gene="rnc" /locus_tag="BSU_15930" /old_locus_tag="BSU15930" /EC_number="3.1.26.3" /experiment="publication(s) with functional evidences, PMID:11123676, 12682299, 16179796, 22412379, 23300471, 26883633" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11123676, 12682299, 16179796, 22412379, 23300471, 26883633; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease III" /protein_id="NP_389475.1" /db_xref="EnsemblGenomes-Gn:BSU15930" /db_xref="EnsemblGenomes-Tr:CAB13466" /db_xref="GOA:P51833" /db_xref="InterPro:IPR000999" /db_xref="InterPro:IPR011907" /db_xref="InterPro:IPR014720" /db_xref="InterPro:IPR036389" /db_xref="SubtiList:BG11537" /db_xref="UniProtKB/Swiss-Prot:P51833" /translation="MSKHSHYKDKKKFYKKVEQFKEFQERISVHFQNEKLLYQAFTHS SYVNEHRKKPYEDNERLEFLGDAVLELTISRFLFAKYPAMSEGDLTKLRAAIVCEPSL VSLAHELSFGDLVLLGKGEEMTGGRKRPALLADVFEAFIGALYLDQGLEPVESFLKVY VFPKINDGAFSHVMDFKSQLQEYVQRDGKGSLEYKISNEKGPAHNREFEAIVSLKGEP LGVGNGRSKKEAEQHAAQEALAKLQKHHTKQ*" /label="rnc CDS" gene 1578038..1578787 /gene="rnc" /locus_tag="BSU_15930" /old_locus_tag="BSU15930" /label="rnc gene" downshifts 1578759 /Source="Nicolas_upshifts" /id="D884" /incds=0 /nref=78 /ntot=211 /MaxReadThrough="6.42554" /MaxDrop="5.70849" /score="-8.42930766" /energy="-17.4" /TU="U1307,U1308,U1309" /idTUdmin="U1306" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1578829..1578835 /Source="Nicolas_upshift_promotors" /id="U1310" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.816183816183816" /psig="0.985014985014985" /xcortree=110 /SigmaFactorBS="ggatttcagtatgtatgccgTCTTATTtgaccaatgttTATG ATAGAATTGAAATACTtattacataaggaggatcgctatgttcctcaaacgtttagac g" /listShort="smc, ftsY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1578847..1578866 /Source="Nicolas_upshift_promotors" /id="U1310" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.816183816183816" /psig="0.985014985014985" /xcortree=110 /SigmaFactorBS="ggatttcagtatgtatgccgTCTTATTtgaccaatgttTATG ATAGAATTGAAATACTtattacataaggaggatcgctatgttcctcaaacgtttagac g" /listShort="smc, ftsY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1578869 /Source="Nicolas_upshifts" /id="U1310" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.816183816183816" /psig="0.985014985014985" /xcortree=110 /SigmaFactorBS="ggatttcagtatgtatgccgTCTTATTtgaccaatgttTATG ATAGAATTGAAATACTtattacataaggaggatcgctatgttcctcaaacgtttagac g" /listShort="smc, ftsY" /GFF_Attribute="listLong" /label="upshifts" CDS 1578888..1582448 /gene="smc" /locus_tag="BSU_15940" /old_locus_tag="BSU15940" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:9701812, 12100548, 12682299, 12897137, 15987505, 16272394, 26904953, 28154080" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9701812, 12100548, 12682299, 12897137, 15987505, 16272394, 26904953, 28154080; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="chromosome condensation and segregation SMC ATPase" /protein_id="NP_389476.2" /db_xref="EnsemblGenomes-Gn:BSU15940" /db_xref="EnsemblGenomes-Tr:CAB13467" /db_xref="GOA:P51834" /db_xref="InterPro:IPR003395" /db_xref="InterPro:IPR010935" /db_xref="InterPro:IPR011890" /db_xref="InterPro:IPR024704" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036277" /db_xref="PDB:3ZGX" /db_xref="PDB:5H66" /db_xref="PDB:5H67" /db_xref="PDB:5NMO" /db_xref="PDB:5NNV" /db_xref="PDB:5XG3" /db_xref="SubtiList:BG11538" /db_xref="UniProtKB/Swiss-Prot:P51834" /translation="MFLKRLDVIGFKSFAERISVDFVKGVTAVVGPNGSGKSNITDAI RWVLGEQSARSLRGGKMEDIIFAGSDSRKRLNLAEVTLTLDNDDHFLPIDFHEVSVTR RVYRSGESEFLINNQPCRLKDIIDLFMDSGLGKEAFSIISQGKVEEILSSKAEDRRSI FEEAAGVLKYKTRKKKAENKLFETQDNLNRVEDILHELEGQVEPLKIQASIAKDYLEK KKELEHVEIALTAYDIEELHGKWSTLKEKVQMAKEEELAESSAISAKEAKIEDTRDKI QALDESVDELQQVLLVTSEELEKLEGRKEVLKERKKNAVQNQEQLEEAIVQFQQKETV LKEELSKQEAVFETLQAEVKQLRAQVKEKQQALSLHNENVEEKIEQLKSDYFELLNSQ ASIRNELQLLDDQMSQSAVTLQRLADNNEKHLQERHDISARKAACETEFARIEQEIHS QVGAYRDMQTKYEQKKRQYEKNESALYQAYQYVQQARSKKDMLETMQGDFSGFYQGVK EVLKAKERLGGIRGAVLELISTEQKYETAIEIALGASAQHVVTDDEQSARKAIQYLKQ NSFGRATFLPLSVIRDRQLQSRDAETAARHSSFLGVASELVTFDPAYRSVIQNLLGTV LITEDLKGANELAKLLGHRYRIVTLEGDVVNPGGSMTGGAVKKKNNSLLGRSRELEDV TKRLAEMEEKTALLEQEVKTLKHSIQDMEKKLADLRETGEGLRLKQQDVKGQLYELQV AEKNINTHLELYDQEKSALSESDEERKVRKRKLEEELSAVSEKMKQLEEDIDRLTKQK QTQSSTKESLSNELTELKIAAAKKEQACKGEEDNLARLKKELTETELALKEAKEDLSF LTSEMSSSTSGEEKLEEAAKHKLNDKTKTIELIALRRDQRIKLQHGLDTYERELKEMK RLYKQKTTLLKDEEVKLGRMEVELDNLLQYLREEYSLSFEGAKEKYQLETDPEEARKR VKLIKLAIEELGTVNLGSIDEFERVNERYKFLSEQKEDLTEAKNTLFQVIEEMDEEMT KRFNDTFVQIRSHFDQVFRSLFGGGRAELRLTDPNDLLHSGVEIIAQPPGKKLQNLNL LSGGERALTAIALLFSILKVRPVPFCVLDEVEAALDEANVFRFAQYLKKYSSDTQFIV ITHRKGTMEEADVLYGVTMQESGVSKVISVKLEETKEFVQ*" /label="smc CDS" gene 1578888..1582448 /gene="smc" /locus_tag="BSU_15940" /old_locus_tag="BSU15940" /label="smc gene" S_feature complement(1582382..1583452) /Source="Nicolas_S_feature" /locus_tag="new_1670054_1671124_c" /HighExp="Cold, C30, Gly, T0.30H, Pyr, T-4.40H, G135, Lbstat, Fru, T-5.40H" /AntisenseName="ftsY" /AntisenseCor="-3.7172405649441298E-3" /AntisenseRegPval=0 /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S578" CDS 1582468..1583457 /gene="ftsY" /locus_tag="BSU_15950" /old_locus_tag="BSU15950" /function="16.1: Circulate" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11021934, 11123669, 11166993, 12682299, 15995216, 16705751, 22056770" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11021934, 11123669, 11166993, 12682299, 15995216, 16705751, 22056770; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="signal recognition particle (docking protein)" /protein_id="NP_389477.1" /db_xref="EnsemblGenomes-Gn:BSU15950" /db_xref="EnsemblGenomes-Tr:CAB13468" /db_xref="GOA:P51835" /db_xref="InterPro:IPR000897" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004390" /db_xref="InterPro:IPR013822" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036225" /db_xref="SubtiList:BG11539" /db_xref="UniProtKB/Swiss-Prot:P51835" /translation="MSFFKKLKEKITKQTDSVSEKFKDGLEKTRNSFQNKVNDLVSRY RKVDEDFFEELEEVLISADVGFTTVMELIDELKKEVKRRNIQDPKEVQSVISEKLVEI YNSGDEQISELNIQDGRLNVILLVGVNGVGKTTTIGKLAHKMKQEGKSVVLAAGDTFR AGAIEQLEVWGERTGVPVIKQTAGSDPAAVIYDAVHAAKARNADVLICDTAGRLQNKV NLMKELEKVKRVIEREVPEAPHEVLLALDATTGQNAMAQAKEFSKATNVTGIALTKLD GTAKGGIVLAIRNELHIPVKLVGLGEKVDDLQEFDPESYVYGLFSDLVEKADD*" /label="ftsY CDS" gene 1582468..1583457 /gene="ftsY" /locus_tag="BSU_15950" /old_locus_tag="BSU15950" /label="ftsY gene" downshifts 1583444 /Source="Nicolas_upshifts" /id="D885" /incds=0 /nref=220 /ntot=261 /MaxReadThrough="2.98458" /MaxDrop="6.84303" /score="49.5808683" /energy="-14.4" /TU="NA" /idTUdmin="U1307" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1583494..1583979) /gene="ylqB" /locus_tag="BSU_15960" /old_locus_tag="BSU15960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15033535, 22287527" /codon_start=1 /transl_table=11 /product="conserved exported protein of unknown function" /protein_id="NP_389478.1" /db_xref="EnsemblGenomes-Gn:BSU15960" /db_xref="EnsemblGenomes-Tr:CAB13469" /db_xref="GOA:O31737" /db_xref="InterPro:IPR008969" /db_xref="InterPro:IPR008979" /db_xref="SubtiList:BG13401" /db_xref="UniProtKB/Swiss-Prot:O31737" /translation="MKKIGLLFMLCLAALFTIGFPAQQADAAEAPYKASITNISTDGG VYGKINYGQGQYWRVKYNITVSGKLLDQNGQPVPNAPVRFEADTKVGNTTQTASGTTD ANGTFEVPMYLGPAAGYYTYYTSVSVHYYDIIPFRVFSGESRLVSTDNSLYHFAYQVR R*" /label="ylqB CDS" gene complement(1583494..1583979) /gene="ylqB" /locus_tag="BSU_15960" /old_locus_tag="BSU15960" /label="ylqB gene" downshifts complement(1583497) /Source="Nicolas_upshifts" /id="D886" /incds=0 /nref=139 /ntot=244 /MaxReadThrough="6.77251" /MaxDrop="6.10895" /score="32.8428224" /energy="-14.4" /TU="U1311" /idTUdmin="U1311" /TUdmin="-1076" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1584001..1584019) /Source="Nicolas_upshift_promotors" /id="U1311" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2831 /SigmaFactorBS="tatcttgtcaaagcggcgattaacttttccaaaatacGCTAA ATAtcatccaatttatTCCGATATTGTATATGAACcctattttaaggaggatttttat g" /listShort="ylqB, S578" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1584017) /Source="Nicolas_upshifts" /id="U1311" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2831 /SigmaFactorBS="tatcttgtcaaagcggcgattaacttttccaaaatacGCTAA ATAtcatccaatttatTCCGATATTGTATATGAACcctattttaaggaggatttttat g" /listShort="ylqB, S578" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1584033..1584040) /Source="Nicolas_upshift_promotors" /id="U1311" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2831 /SigmaFactorBS="tatcttgtcaaagcggcgattaacttttccaaaatacGCTAA ATAtcatccaatttatTCCGATATTGTATATGAACcctattttaaggaggatttttat g" /listShort="ylqB, S578" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1584082..1584088 /Source="Nicolas_upshift_promotors" /id="U1312" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.709290709290709" /psig=1 /xcortree=2649 /SigmaFactorBS="tttggaaaagttaatcgccgctttgacaagataaaaaCTTGA CAgtgtcattaaaaccGTGTAAACTAAGTTATCGTAaagggatttgacttaacaaagg g" /listShort="ylxM, ffh, S579, rpsP, ylqC, S580, ylqD, rimM, trmD" /listLong="NA, rplS, S581, rbgA, rnhB, ylqG, ylqH, S582, sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1584103..1584122 /Source="Nicolas_upshift_promotors" /id="U1312" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.709290709290709" /psig=1 /xcortree=2649 /SigmaFactorBS="tttggaaaagttaatcgccgctttgacaagataaaaaCTTGA CAgtgtcattaaaaccGTGTAAACTAAGTTATCGTAaagggatttgacttaacaaagg g" /listShort="ylxM, ffh, S579, rpsP, ylqC, S580, ylqD, rimM, trmD" /listLong="NA, rplS, S581, rbgA, rnhB, ylqG, ylqH, S582, sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" upshifts 1584105 /Source="Nicolas_upshifts" /id="U1312" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.709290709290709" /psig=1 /xcortree=2649 /SigmaFactorBS="tttggaaaagttaatcgccgctttgacaagataaaaaCTTGA CAgtgtcattaaaaccGTGTAAACTAAGTTATCGTAaagggatttgacttaacaaagg g" /listShort="ylxM, ffh, S579, rpsP, ylqC, S580, ylqD, rimM, trmD" /listLong="NA, rplS, S581, rbgA, rnhB, ylqG, ylqH, S582, sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" CDS 1584156..1584488 /gene="ylxM" /locus_tag="BSU_15970" /old_locus_tag="BSU15970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11274114, 24659773; Product type f: factor" /codon_start=1 /transl_table=11 /product="component of the signal recognition particle (SRP) protein-targeting pathway" /protein_id="NP_389479.1" /db_xref="EnsemblGenomes-Gn:BSU15970" /db_xref="EnsemblGenomes-Tr:CAB13470" /db_xref="GOA:P37104" /db_xref="InterPro:IPR007394" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10829" /db_xref="UniProtKB/Swiss-Prot:P37104" /translation="MSLEKTTRMNYLFDFYQSLLTSKQKSYMSLYYLDDFSLGEIAEE YEVSRQAVYDNIKRTEAMLEQYEEKLLLLKKFQERKEMFNKLKELASGSKEEEEITAL IEALEKLD*" /label="ylxM CDS" gene 1584156..1584488 /gene="ylxM" /locus_tag="BSU_15970" /old_locus_tag="BSU15970" /label="ylxM gene" downshifts complement(1584159) /Source="Nicolas_upshifts" /id="D887" /incds=0 /nref=3 /ntot=52 /MaxReadThrough="1.40385" /MaxDrop="4.6092" /score="32.8428224" /energy="-14.4" /TU="NA" /idTUdmin="U1311" /TUdmin="-1738" /isTUend="FALSE" /label="downshifts" CDS 1584502..1585842 /gene="ffh" /locus_tag="BSU_15980" /old_locus_tag="BSU15980" /function="16.13: Shape" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7511896, 8662730, 10222262, 10224127, 10658653, 12682299, 11123669, 22056770, 26344568" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7511896, 8662730, 10222262, 10224127, 10658653, 12682299, 11123669, 22056770, 26344568; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="signal recognition particle-like (SRP) GTPase" /protein_id="NP_389480.1" /db_xref="EnsemblGenomes-Gn:BSU15980" /db_xref="EnsemblGenomes-Tr:CAB13471" /db_xref="GOA:P37105" /db_xref="InterPro:IPR000897" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004125" /db_xref="InterPro:IPR004780" /db_xref="InterPro:IPR013822" /db_xref="InterPro:IPR022941" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036891" /db_xref="PDB:4UE4" /db_xref="SubtiList:BG10830" /db_xref="UniProtKB/Swiss-Prot:P37105" /translation="MAFEGLADRLQQTISKIRGKGKVSEQDVKEMMREVRLALLEADV NFKVVKDFVKKVSERAVGQDVMKSLTPGQQVIKVVQEELTELMGGEESKIAVAKRPPT VIMMVGLQGAGKTTTSGKLANLLRKKHNRKPMLVAADIYRPAAIKQLETLGKQLDMPV FSLGDQVSPVEIAKQAIEKAKEEHYDYVILDTAGRLHIDHELMDELTNVKEIANPEEI FLVVDSMTGQDAVNVAKSFNEQLGLTGVVLTKLDGDTRGGAALSIRAVTNTPIKFAGL GEKLDALEPFHPERMASRILGMGDVLTLIEKAQASVDEDKAKELEQKMRTMSFTLDDF LEQLGQVRNMGPLDELLQMMPGAGKMKGLKNIQVDEKQLNHVEAIIKSMTVLEKEQPD IINASRRKRIAKGSGTSVQEVNRLLKQFDEMKKMMKQMTNMSKGKKKGFKLPFM*" /label="ffh CDS" gene 1584502..1585842 /gene="ffh" /locus_tag="BSU_15980" /old_locus_tag="BSU15980" /label="ffh gene" S_feature 1585843..1585947 /Source="Nicolas_S_feature" /locus_tag="new_1673515_1673619" /HighExp="Cold, G135, C30, G180, LPhT, HPh, Paraq, LPh, Oxctl, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S579" CDS 1585948..1586220 /gene="rpsP" /locus_tag="BSU_15990" /old_locus_tag="BSU15990" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6419023, 12682299, 20034956" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6419023, 12682299, 20034956; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S16 (BS17)" /protein_id="NP_389481.1" /db_xref="EnsemblGenomes-Gn:BSU15990" /db_xref="EnsemblGenomes-Tr:CAB13472" /db_xref="GOA:P21474" /db_xref="InterPro:IPR000307" /db_xref="InterPro:IPR020592" /db_xref="InterPro:IPR023803" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10831" /db_xref="UniProtKB/Swiss-Prot:P21474" /translation="MAVKIRLKRMGAKKSPFYRIVVADSRSPRDGRFIETVGTYNPVA KPAEVKIDEELALKWLQTGAKPSDTVRNLFSSQGIMEKFHNAKQGK*" /label="rpsP CDS" gene 1585948..1586220 /gene="rpsP" /locus_tag="BSU_15990" /old_locus_tag="BSU15990" /label="rpsP gene" CDS 1586220..1586465 /gene="ylqC" /locus_tag="BSU_16000" /old_locus_tag="BSU16000" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22333191, 22720735, 26483775; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative RNA binding protein" /protein_id="NP_389482.1" /db_xref="EnsemblGenomes-Gn:BSU16000" /db_xref="EnsemblGenomes-Tr:CAB13473" /db_xref="GOA:O31738" /db_xref="InterPro:IPR009019" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR020627" /db_xref="SubtiList:BG13402" /db_xref="UniProtKB/Swiss-Prot:O31738" /translation="MTDQHLEDLIVHIVTPLVDHPDDIRVIREETDQKIALRLSVHKS DTGKVIGKQGRTAKAIRTAVFAAGVQSSKKVQFEIFD*" /label="ylqC CDS" gene 1586220..1586465 /gene="ylqC" /locus_tag="BSU_16000" /old_locus_tag="BSU16000" /label="ylqC gene" downshifts 1586437 /Source="Nicolas_upshifts" /id="D888" /incds=0 /nref=41 /ntot=178 /MaxReadThrough="6.57974" /MaxDrop="4.803" /score="-7.01631592" /energy="-5.6" /TU="U1312" /idTUdmin="U1312" /TUdmin="-1804" /isTUend="FALSE" /label="downshifts" S_feature 1586482..1586586 /Source="Nicolas_S_feature" /locus_tag="new_1674154_1674258" /HighExp="G180, Oxctl, G150, G135, Paraq, LBGexp, H2O2, HPh, LPh, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S580" CDS 1586587..1586973 /gene="ylqD" /locus_tag="BSU_16010" /old_locus_tag="BSU16010" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389483.1" /db_xref="EnsemblGenomes-Gn:BSU16010" /db_xref="EnsemblGenomes-Tr:CAB13474" /db_xref="InterPro:IPR021297" /db_xref="SubtiList:BG13403" /db_xref="UniProtKB/Swiss-Prot:O31739" /translation="MQIIHRVAVMQVLTERSKEKLLASFAEKKQMLERECSQLYFQLR KHEKEQQNPNMIEQFKKAIEKRKDDIKIIDFQIAQVHTLPLGSELKEKEVDALLTIEA GDDWHEKTAANTIVIKDGKVIEIRQR*" /label="ylqD CDS" gene 1586587..1586973 /gene="ylqD" /locus_tag="BSU_16010" /old_locus_tag="BSU16010" /label="ylqD gene" CDS 1586978..1587502 /gene="rimM" /locus_tag="BSU_16020" /old_locus_tag="BSU16020" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15496525, 16014871, 27382067; Product type f: factor" /codon_start=1 /transl_table=11 /product="16S rRNA processing protein" /protein_id="NP_389484.1" /db_xref="EnsemblGenomes-Gn:BSU16020" /db_xref="EnsemblGenomes-Tr:CAB13475" /db_xref="GOA:O31740" /db_xref="InterPro:IPR002676" /db_xref="InterPro:IPR009000" /db_xref="InterPro:IPR011033" /db_xref="InterPro:IPR011961" /db_xref="InterPro:IPR027275" /db_xref="InterPro:IPR036976" /db_xref="SubtiList:BG13404" /db_xref="UniProtKB/Swiss-Prot:O31740" /translation="MTKRWFNVGKIVNTHGIKGEVRVISKTDFAEERYKPGNTLYLFM DGRNEPVEVTVNTHRLHKQFHLLQFKERQNLNEVEELKNAIIKVPEEELGELNEGEFY FHEIIGCEVFTEEGELIGKVKEILTPGANDVWVIGRKGKKDALIPYIESVVKHIDVRE KKIEIELMEGLIDE*" /label="rimM CDS" gene 1586978..1587502 /gene="rimM" /locus_tag="BSU_16020" /old_locus_tag="BSU16020" /label="rimM gene" CDS 1587499..1588230 /gene="trmD" /locus_tag="BSU_16030" /old_locus_tag="BSU16030" /EC_number="2.1.1.228" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10094308, 11532950, 12682299, 12773376, 15060037, 27881678, 28601227; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA(m1G37)methyltransferase" /protein_id="NP_389485.1" /db_xref="EnsemblGenomes-Gn:BSU16030" /db_xref="EnsemblGenomes-Tr:CAB13476" /db_xref="GOA:O31741" /db_xref="InterPro:IPR002649" /db_xref="InterPro:IPR016009" /db_xref="InterPro:IPR029026" /db_xref="InterPro:IPR029028" /db_xref="SubtiList:BG12687" /db_xref="UniProtKB/Swiss-Prot:O31741" /translation="MKIDFLTLFPEMFEGVLGSSILQKAQEKDAVQFQVVNFREYSDN KHNTVDDYPYGGGAGMVLKPQPVFDAVEDLTSKAAAAPRIILVCPQGERFTQKKAEQL AKEEHLLFICGHYEGYDERIREHLVTDEISIGDFVLTGGELPAMMIADSVVRLLPGVL GKEASHIEDSFSTGLLEHPHYTRPADYKGLKVPETLLSGNHAKIEEWRNKESIRRTYL RRPDLLKDHPLTEQQRKWISEWEKE*" /label="trmD CDS" gene 1587499..1588230 /gene="trmD" /locus_tag="BSU_16030" /old_locus_tag="BSU16030" /label="trmD gene" promotor_-35 1588236..1588243 /Source="Nicolas_upshift_promotors" /id="U1313" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.822177822177822" /psig=1 /xcortree=2646 /SigmaFactorBS="aagtggatttctgaatgggaaaaagaatagattttATTGCAT AggctatgaaattgTGATAAGATACTACTTGTGGcttaagcgggcttatccgctgcaa g" /listShort="NA, rplS, S581, rbgA, rnhB, ylqG, ylqH, S582" /listLong="sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1588257..1588276 /Source="Nicolas_upshift_promotors" /id="U1313" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.822177822177822" /psig=1 /xcortree=2646 /SigmaFactorBS="aagtggatttctgaatgggaaaaagaatagattttATTGCAT AggctatgaaattgTGATAAGATACTACTTGTGGcttaagcgggcttatccgctgcaa g" /listShort="NA, rplS, S581, rbgA, rnhB, ylqG, ylqH, S582" /listLong="sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" upshifts 1588261 /Source="Nicolas_upshifts" /id="U1313" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.822177822177822" /psig=1 /xcortree=2646 /SigmaFactorBS="aagtggatttctgaatgggaaaaagaatagattttATTGCAT AggctatgaaattgTGATAAGATACTACTTGTGGcttaagcgggcttatccgctgcaa g" /listShort="NA, rplS, S581, rbgA, rnhB, ylqG, ylqH, S582" /listLong="sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" misc_RNA 1588309..1588350 /locus_tag="BSU_misc_RNA_30" /product="L19_leader" /label="L19 leader RNA" gene 1588309..1588350 /locus_tag="BSU_misc_RNA_30" /label="gene" CDS 1588370..1588717 /gene="rplS" /locus_tag="BSU_16040" /old_locus_tag="BSU16040" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 16272117, 27477481; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosomal protein L19" /protein_id="NP_389486.2" /db_xref="EnsemblGenomes-Gn:BSU16040" /db_xref="EnsemblGenomes-Tr:CAB13477" /db_xref="GOA:O31742" /db_xref="InterPro:IPR001857" /db_xref="InterPro:IPR008991" /db_xref="InterPro:IPR018257" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG12667" /db_xref="UniProtKB/Swiss-Prot:O31742" /translation="MQKLIEDITKEQLRTDLPAFRPGDTLRVHVKVVEGNRERIQIFE GVVIKRRGGGISETFTVRKISYGVGVERTFPVHTPKIAKIEVVRYGKVRRAKLYYLRE LRGKAARIKEIRR*" /label="rplS CDS" gene 1588370..1588717 /gene="rplS" /locus_tag="BSU_16040" /old_locus_tag="BSU16040" /label="rplS gene" downshifts 1588719 /Source="Nicolas_upshifts" /id="D889" /incds=0 /nref=212 /ntot=274 /MaxReadThrough="6.00308" /MaxDrop="9.06015" /score="23.9942041" /energy="-12.6" /TU="U1313" /idTUdmin="U1312" /TUdmin=478 /isTUend="FALSE" /label="downshifts" promotor_-35 1588772..1588778 /Source="Nicolas_upshift_promotors" /id="U1314" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.496503496503497" /psig="0.995004995004995" /xcortree=2756 /SigmaFactorBS="aaagagcttgttacctgtaacaagctctttttttatacagaA TTTGAAaatgccggacaggCATCGTAAAATACATAAAGGacaacaatgaatcatgcat a" /listShort="S581, rbgA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1588791..1588859 /Source="Nicolas_S_feature" /locus_tag="new_1676463_1676531" /HighExp="Oxctl, G180, Paraq, G135, H2O2, LBGstat, dia15, G150, HPh, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.149563" /TUshortSig="SigA, SigA" /TUshortPSig="0.995, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S581" upshifts 1588791 /Source="Nicolas_upshifts" /id="U1314" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.496503496503497" /psig="0.995004995004995" /xcortree=2756 /SigmaFactorBS="aaagagcttgttacctgtaacaagctctttttttatacagaA TTTGAAaatgccggacaggCATCGTAAAATACATAAAGGacaacaatgaatcatgcat a" /listShort="S581, rbgA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1588792..1588811 /Source="Nicolas_upshift_promotors" /id="U1314" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.496503496503497" /psig="0.995004995004995" /xcortree=2756 /SigmaFactorBS="aaagagcttgttacctgtaacaagctctttttttatacagaA TTTGAAaatgccggacaggCATCGTAAAATACATAAAGGacaacaatgaatcatgcat a" /listShort="S581, rbgA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1588860..1589708 /gene="rbgA" /locus_tag="BSU_16050" /old_locus_tag="BSU16050" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 16390447, 16431913, 16997968, 17613524, 22267738, 25330043, 26951678" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16390447, 16431913, 16997968, 17613524, 22267738, 25330043, 26951678; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribosome biogenesis GTPase A" /protein_id="NP_389487.1" /db_xref="EnsemblGenomes-Gn:BSU16050" /db_xref="EnsemblGenomes-Tr:CAB13478" /db_xref="GOA:O31743" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR016478" /db_xref="InterPro:IPR019991" /db_xref="InterPro:IPR023179" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030378" /db_xref="PDB:1PUJ" /db_xref="SubtiList:BG13405" /db_xref="UniProtKB/Swiss-Prot:O31743" /translation="MTIQWFPGHMAKARREVTEKLKLIDIVYELVDARIPMSSRNPMI EDILKNKPRIMLLNKADKADAAVTQQWKEHFENQGIRSLSINSVNGQGLNQIVPASKE ILQEKFDRMRAKGVKPRAIRALIIGIPNVGKSTLINRLAKKNIAKTGDRPGITTSQQW VKVGKELELLDTPGILWPKFEDELVGLRLAVTGAIKDSIINLQDVAVFGLRFLEEHYP ERLKERYGLDEIPEDIAELFDAIGEKRGCLMSGGLINYDKTTEVIIRDIRTEKFGRLS FEQPTM*" /label="rbgA CDS" gene 1588860..1589708 /gene="rbgA" /locus_tag="BSU_16050" /old_locus_tag="BSU16050" /label="rbgA gene" promotor_-35 1589729..1589736 /Source="Nicolas_upshift_promotors" /id="U1315" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2823 /SigmaFactorBS="gacgatgtaaaggcgcgcagaaatgcgggtCTTTATTTtttc ttggctgaACCGATACATACAGTAAGGgagaagagaaagtgaatacattaaccgtaaa g" /listShort="rnhB, ylqG, ylqH, S582" /listLong="sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1589749..1589767 /Source="Nicolas_upshift_promotors" /id="U1315" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2823 /SigmaFactorBS="gacgatgtaaaggcgcgcagaaatgcgggtCTTTATTTtttc ttggctgaACCGATACATACAGTAAGGgagaagagaaagtgaatacattaaccgtaaa g" /listShort="rnhB, ylqG, ylqH, S582" /listLong="sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" upshifts 1589759 /Source="Nicolas_upshifts" /id="U1315" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2823 /SigmaFactorBS="gacgatgtaaaggcgcgcagaaatgcgggtCTTTATTTtttc ttggctgaACCGATACATACAGTAAGGgagaagagaaagtgaatacattaaccgtaaa g" /listShort="rnhB, ylqG, ylqH, S582" /listLong="sucC, sucD, dprA, S583, topA, trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" CDS 1589779..1590546 /gene="rnhB" /locus_tag="BSU_16060" /old_locus_tag="BSU16060" /EC_number="3.1.26.4" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10094689, 12475934, 23882084, 23937561, 29078353" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094689, 12475934, 23882084, 23937561, 29078353; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease HII" /protein_id="NP_389488.1" /db_xref="EnsemblGenomes-Gn:BSU16060" /db_xref="EnsemblGenomes-Tr:CAB13479" /db_xref="GOA:O31744" /db_xref="InterPro:IPR001352" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR022898" /db_xref="InterPro:IPR024567" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG12666" /db_xref="UniProtKB/Swiss-Prot:O31744" /translation="MNTLTVKDIKDRLQEVKDAQDPFIAQCENDPRKSVQTLVEQWLK KQAKEKALKEQWVNMTSYERLARNKGFRLIAGVDEVGRGPLAGPVVASAVILPEECEI LGLTDSKKLSEKKREEYYELIMKEALAVGIGIVEATVIDEINIYEASKMAMVKAIQDL SDTPDYLLVDAMTLPLDTAQASIIKGDAKSVSIAAGACIAKVTRDRMMSAYAETYPMY GFEKNKGYGTKEHLEALAAYGPTELHRKTFAPVQSFR*" /label="rnhB CDS" gene 1589779..1590546 /gene="rnhB" /locus_tag="BSU_16060" /old_locus_tag="BSU16060" /label="rnhB gene" CDS 1590578..1592308 /gene="ylqG" /locus_tag="BSU_16070" /old_locus_tag="BSU16070" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_389489.1" /db_xref="EnsemblGenomes-Gn:BSU16070" /db_xref="EnsemblGenomes-Tr:CAB13480" /db_xref="SubtiList:BG13406" /db_xref="UniProtKB/Swiss-Prot:O31745" /translation="MNIRNDVQKALQHLFGRTAVPQETSKVNEALNGEKRLLLGKVLR LLGDQHALIQVGNQTVQGKLETQLRPQAYYWFSYEKKTAEQTGRLQVVQSFDQNPKTI QDAAGKLLNAISVKTSNAALMMTGAMLKSKTPVTENDIKTAVRWMDTLPSQDTKKAVE TVLFALKRDLPIHSEILNGVHAVKSPVPLHQHVSQLLQAIDQNPQQSQMMSKLKEAVT VLLNSEIDVHAERLIDKLISLTDNTKAPSPTNTAGSRELSTPAGSPGKASLPIANHTA EQGSIQEEPVKTAADIPIKEARQLLVKLTESAEKNSLQIVKEAANWIKAAASSGDSKS LAASAVLQAAQVTDQEAEVFLKAVQQTAPHLADKADVLSFLSKVKTAIGARDEVAFIK AFEQGSAVTSGEMQSIKLALSALRASHEVAEPVKQEADQLFHKLNGQLFMQQDHPSYS QIVMSFPMFSKSGVQDMTVLFKGKKEADGKLDPSHCRLLFLLQLDTLKETVVDCLVQQ KVMTITIETDFELQAAIDPMVPALKQGLKEMGYSLSGVNAKKRVHTEEKASIDQYITS ISDQEVDVKI*" /label="ylqG CDS" gene 1590578..1592308 /gene="ylqG" /locus_tag="BSU_16070" /old_locus_tag="BSU16070" /label="ylqG gene" upshifts complement(1591815) /Source="Nicolas_upshifts" /id="U1316" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.78921078921079" /psig="0.827172827172827" /xcortree=1797 /SigmaFactorBS="aaaagctgatcggcttctTGTTTGACtggttcggctacctCA TGCGATGCTCTTAAGGCAgaaagagccagcttgatggattgcatttcgccagatgtga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1591816..1591835) /Source="Nicolas_upshift_promotors" /id="U1316" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.78921078921079" /psig="0.827172827172827" /xcortree=1797 /SigmaFactorBS="aaaagctgatcggcttctTGTTTGACtggttcggctacctCA TGCGATGCTCTTAAGGCAgaaagagccagcttgatggattgcatttcgccagatgtga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1591850..1591857) /Source="Nicolas_upshift_promotors" /id="U1316" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.78921078921079" /psig="0.827172827172827" /xcortree=1797 /SigmaFactorBS="aaaagctgatcggcttctTGTTTGACtggttcggctacctCA TGCGATGCTCTTAAGGCAgaaagagccagcttgatggattgcatttcgccagatgtga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1592305..1592586 /gene="ylqH" /locus_tag="BSU_16080" /old_locus_tag="BSU16080" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative flagellar biosynthesis protein" /protein_id="NP_389490.1" /db_xref="EnsemblGenomes-Gn:BSU16080" /db_xref="EnsemblGenomes-Tr:CAB13481" /db_xref="GOA:O34867" /db_xref="InterPro:IPR004683" /db_xref="InterPro:IPR006135" /db_xref="InterPro:IPR029025" /db_xref="SubtiList:BG13407" /db_xref="UniProtKB/Swiss-Prot:O34867" /translation="MKEQTPIRKAVALHYDEQKDKAPRVIATGKGHVADNIIKEAKKA GVPIQEDRTLVELMRHLTVDDQIPEALYETVAEIFSFIYKLDESVKNKK*" /label="ylqH CDS" gene 1592305..1592586 /gene="ylqH" /locus_tag="BSU_16080" /old_locus_tag="BSU16080" /label="ylqH gene" downshifts 1592418 /Source="Nicolas_upshifts" /id="D890" /incds=1 /nref=7 /ntot=136 /MaxReadThrough="4.03339" /MaxDrop="4.52065" /score="-6.81136789" /energy="-9.2" /TU="U1313,U1315" /idTUdmin="U1313" /TUdmin="-267" /isTUend="FALSE" /label="downshifts" S_feature 1592587..1592706 /Source="Nicolas_S_feature" /locus_tag="new_1680259_1680378" /HighExp="Cold, Lbstat, H2O2, Glu, Paraq, Mal, G135, GM 90, Oxctl, Fru" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigA" /TUshortPSig="1, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S582" promotor_-35 1592678..1592685 /Source="Nicolas_upshift_promotors" /id="U1317" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.55044955044955" /psig="0.999000999001" /xcortree=2227 /SigmaFactorBS="ttagaaggattaaaagattttgcatcgaacTGTAGACAattc ttccagtatTATTATAGAATGAAAGCGCAgtctattttagttttgttacataagttag g" /listShort="sucC, sucD, dprA, S583, topA" /listLong="trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1592699..1592718 /Source="Nicolas_upshift_promotors" /id="U1317" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.55044955044955" /psig="0.999000999001" /xcortree=2227 /SigmaFactorBS="ttagaaggattaaaagattttgcatcgaacTGTAGACAattc ttccagtatTATTATAGAATGAAAGCGCAgtctattttagttttgttacataagttag g" /listShort="sucC, sucD, dprA, S583, topA" /listLong="trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" upshifts 1592708 /Source="Nicolas_upshifts" /id="U1317" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.55044955044955" /psig="0.999000999001" /xcortree=2227 /SigmaFactorBS="ttagaaggattaaaagattttgcatcgaacTGTAGACAattc ttccagtatTATTATAGAATGAAAGCGCAgtctattttagttttgttacataagttag g" /listShort="sucC, sucD, dprA, S583, topA" /listLong="trmFO, codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" CDS 1592759..1593916 /gene="sucC" /locus_tag="BSU_16090" /old_locus_tag="BSU16090" /EC_number="6.2.1.4" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 2548486, 22720735, 22751660; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="succinyl-CoA synthetase (beta subunit)" /protein_id="NP_389491.1" /db_xref="EnsemblGenomes-Gn:BSU16090" /db_xref="EnsemblGenomes-Tr:CAB13482" /db_xref="GOA:P80886" /db_xref="InterPro:IPR005809" /db_xref="InterPro:IPR005811" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR013650" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016102" /db_xref="InterPro:IPR017866" /db_xref="SubtiList:BG12680" /db_xref="UniProtKB/Swiss-Prot:P80886" /translation="MNIHEYQGKEVLRKYGVSVPEGKVAFTAEEAVESAKSLSSSVYV VKAQIHAGGRGKAGGVKIAKSLDEVKAYAEELLGKTLVTHQTGPDGQVIKRLLIEEGC DIKKEYYIGLVLDRATSRIVLMASEEGGTEIEEVAEKTPEKIKKAVIDPAVGLQGYQA REIAFAINIPKELVGKAAKFMLGLYKAFVEKDCSIAEINPLVVTGDGNVMALDAKLNF DSNALYRQKDIMEYRDLDEEDPKEIEASKYDLSYISLDGNIGCMVNGAGLAMSTMDII KHYGGEPANFLDVGGGATAEKVTEAFKIILSDQNVKGIFVNIFGGIMKCDVIAEGVVE ATRQVGLTLPLVVRLEGTNVDLGKKILSESGLNITSAESMADGAQKIVSLV*" /label="sucC CDS" gene 1592759..1593916 /gene="sucC" /locus_tag="BSU_16090" /old_locus_tag="BSU16090" /label="sucC gene" promotor_no_box complement(1592831..1592931) /Source="Nicolas_upshift_promotors" /id="U1318" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.864135864135864" /psig="0.0929070929070929" /xcortree=73 /SigmaFactorBS="ccagctttgcctcgaccgccagcatgaatttgagcctttacg acataaaccgagctggataagctctttgcactctcaactgcttcttctgctgtaaaag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1592871) /Source="Nicolas_upshifts" /id="U1318" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.864135864135864" /psig="0.0929070929070929" /xcortree=73 /SigmaFactorBS="ccagctttgcctcgaccgccagcatgaatttgagcctttacg acataaaccgagctggataagctctttgcactctcaactgcttcttctgctgtaaaag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 1593945..1594847 /gene="sucD" /locus_tag="BSU_16100" /old_locus_tag="BSU16100" /EC_number="6.2.1.4" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 9643546, 22720735, 22751660; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="succinyl-CoA synthetase (alpha subunit)" /protein_id="NP_389492.1" /db_xref="EnsemblGenomes-Gn:BSU16100" /db_xref="EnsemblGenomes-Tr:CAB13483" /db_xref="GOA:P80865" /db_xref="InterPro:IPR003781" /db_xref="InterPro:IPR005810" /db_xref="InterPro:IPR005811" /db_xref="InterPro:IPR016102" /db_xref="InterPro:IPR017440" /db_xref="InterPro:IPR033847" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12681" /db_xref="UniProtKB/Swiss-Prot:P80865" /translation="MSVFINKDTRVIVQGITGSTALFHTKQMLEYGTNIVGGVTPGKG GTEAEGVPVFNTVAEAVQTTGANASVIYVPAPFAADAIMEAVDAELDLVICITEHIPV LDMVKVKRFMEGKKTRLIGPNCPGVITPEECKIGIMPGYIHKKGHVGVVSRSGTLTYE AVHQLSEAGVGQSTAVGIGGDPVNGTNFIDVLKAFNEDPDTHAVIMIGEIGGTAEEEA AEWVKANMTKPVVGFIGGKTAPPGKRMGHAGAIISGGKGTADEKIKTLNACGIEVAET PSVMGETLIKVLKEKNLFETCKTH*" /label="sucD CDS" gene 1593945..1594847 /gene="sucD" /locus_tag="BSU_16100" /old_locus_tag="BSU16100" /label="sucD gene" downshifts 1594837 /Source="Nicolas_upshifts" /id="D891" /incds=0 /nref=94 /ntot=208 /MaxReadThrough="5.40077" /MaxDrop="4.8878" /score="9.51199539" /energy="-15" /TU="U1317" /idTUdmin="U1315" /TUdmin=2130 /isTUend="FALSE" /label="downshifts" CDS 1594908..1595801 /gene="dprA" /locus_tag="BSU_16110" /old_locus_tag="BSU16110" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16014871, 16978360, 17803906, 18045469, 7768823, 23779106, 25138221, 28618091" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16014871, 16978360, 17803906, 18045469, 7768823, 23779106, 25138221, 28618091; Product type f: factor" /codon_start=1 /transl_table=11 /product="DNA processing Smf single strand binding protein" /protein_id="NP_389493.1" /db_xref="EnsemblGenomes-Gn:BSU16110" /db_xref="EnsemblGenomes-Tr:CAB13484" /db_xref="GOA:P39813" /db_xref="InterPro:IPR003488" /db_xref="SubtiList:BG11006" /db_xref="UniProtKB/Swiss-Prot:P39813" /translation="MDQAAVCLTICRINQLLSPSLLLKWWKADPSMSLTSPVLQTVTR DQIKAAALKNEIEQFYPKLPRVLAAYREQGINTIPISSKQYPFWLKSIYDPPAVLFAK GDMTLLSKGRKIGIVGTRNPTAYGKQVVNHLTKEICRKGWVIVSGLASGIDGMSHAAS IKAKGRTIGVIAGGFQHIYPRENLQLADHMAKHHILLSEHPPETKPQKWHFPMRNRII SGLSEGVIVVQGKEKSGSLITAYQALEQGREVFAVPGSLFDPYAGGPIKLIQQGAKAI WSAEDIFEELPERNVQYTEPF*" /label="dprA CDS" gene 1594908..1595801 /gene="dprA" /locus_tag="BSU_16110" /old_locus_tag="BSU16110" /label="dprA gene" promotor_-35 1595807..1595814 /Source="Nicolas_upshift_promotors" /id="U1319" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.839160839160839" /psig=1 /xcortree=1880 /SigmaFactorBS="acgttcaatatacggaacccttttgaattatCGTTTGACaaa cggtattgtaaTATTTAATAATAGTGAGGATttaaagttgcatattgttttctattta a" /listShort="S583, topA, trmFO" /listLong="codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1595829..1595848 /Source="Nicolas_upshift_promotors" /id="U1319" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.839160839160839" /psig=1 /xcortree=1880 /SigmaFactorBS="acgttcaatatacggaacccttttgaattatCGTTTGACaaa cggtattgtaaTATTTAATAATAGTGAGGATttaaagttgcatattgttttctattta a" /listShort="S583, topA, trmFO" /listLong="codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" S_feature 1595836..1595988 /Source="Nicolas_S_feature" /locus_tag="new_1683508_1683660" /HighExp="dia15, H2O2, G/S, Paraq, Diami, S1, Oxctl, LBGexp, C30, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.111279" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="SigD, SigA, SigA" /TUlongPSig="1, 1, 1" /label="S583" upshifts 1595836 /Source="Nicolas_upshifts" /id="U1319" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.839160839160839" /psig=1 /xcortree=1880 /SigmaFactorBS="acgttcaatatacggaacccttttgaattatCGTTTGACaaa cggtattgtaaTATTTAATAATAGTGAGGATttaaagttgcatattgttttctattta a" /listShort="S583, topA, trmFO" /listLong="codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" CDS 1595989..1598064 /gene="topA" /locus_tag="BSU_16120" /old_locus_tag="BSU16120" /EC_number="5.99.1.2" /function="16.3: Control" /function="16.6: Maintain" /function="16.9: Replicate" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9580687, 12682299, 16585761, 23133654" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9580687, 12682299, 16585761, 23133654; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA topoisomerase I" /protein_id="NP_389494.1" /db_xref="EnsemblGenomes-Gn:BSU16120" /db_xref="EnsemblGenomes-Tr:CAB13485" /db_xref="GOA:P39814" /db_xref="InterPro:IPR000380" /db_xref="InterPro:IPR003601" /db_xref="InterPro:IPR003602" /db_xref="InterPro:IPR005733" /db_xref="InterPro:IPR006171" /db_xref="InterPro:IPR013497" /db_xref="InterPro:IPR013498" /db_xref="InterPro:IPR013825" /db_xref="InterPro:IPR023405" /db_xref="InterPro:IPR023406" /db_xref="InterPro:IPR028612" /db_xref="InterPro:IPR034149" /db_xref="SubtiList:BG11007" /db_xref="UniProtKB/Swiss-Prot:P39814" /translation="MSDYLVIVESPAKAKTIERYLGKKYKVKASMGHVRDLPKSQMGV DIEQNFEPKYITIRGKGPVLKELKTAAKKAKKVYLAADPDREGEAIAWHLAHSLDLDL NSDCRVVFNEITKDAIKESFKHPRMINMDLVDAQQARRILDRLVGYKISPILWKKVKK GLSAGRVQSVALRLIIDREKEINDFKPEEYWTIDGTFLKGQETFEASFFGKNGKKLPL NSEADVKEILSQLKGNQYTVEKVTKKERKRNPALPFTTSTLQQEAARKLNFRAKKTMM IAQQLYEGIDLGREGTVGLITYMRTDSTRISNTAVDEAAAFIDQTYGKEFLGGKRKPA KKNENAQDAHEAIRPTSVLRKPSELKAVLGRDQMRLYKLIWERFVASQMAPAVLDTMS VDLTNNGLTFRANGSKVKFSGFMKVYVEGKDDQMEEKDRMLPDLQEGDTVLSKDIEPE QHFTQPPPRYTEARLVKTLEERGIGRPSTYAPTLDTIQRRGYVALDNKRFVPTELGQI VLDLIMEFFPEIINVEFTAKMERDLDHVEEGNTEWVKIIDNFYTDFEKRVKKAESEMK EVEIEPEYAGEDCELCSSPMVYKMGRYGKFLACSNFPDCRNTKPIVKQIGVKCPSCGE GNIVERKSKKKRVFYGCDRYPDCEFVSWDKPIERKCPKCGKMLVEKKLKKGIQVQCVE CDYKEEPQK*" /label="topA CDS" gene 1595989..1598064 /gene="topA" /locus_tag="BSU_16120" /old_locus_tag="BSU16120" /label="topA gene" downshifts 1598034 /Source="Nicolas_upshifts" /id="D892" /incds=0 /nref=48 /ntot=173 /MaxReadThrough="5.66787" /MaxDrop="4.5486" /score="0.939045188" /energy="-13.2" /TU="U1319" /idTUdmin="U1317" /TUdmin="-19" /isTUend="TRUE" /label="downshifts" promotor_-35 1598096..1598101 /Source="Nicolas_upshift_promotors" /id="U1320" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.588411588411588" /psig="0.588411588411588" /xcortree=1017 /SigmaFactorBS="aagaaccacagaagtagcggtgagcagggtcttgctcacctt ctttgtGTGTTAaaagaaggccttgaaTAATAAACTAGGAGATGTGaaagatgaacca a" /listShort="trmFO, codV, clpQ, clpY, codY" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1598108 /Source="Nicolas_upshifts" /id="U1320" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.588411588411588" /psig="0.588411588411588" /xcortree=1017 /SigmaFactorBS="aagaaccacagaagtagcggtgagcagggtcttgctcacctt ctttgtGTGTTAaaagaaggccttgaaTAATAAACTAGGAGATGTGaaagatgaacca a" /listShort="trmFO, codV, clpQ, clpY, codY" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1598117..1598135 /Source="Nicolas_upshift_promotors" /id="U1320" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.588411588411588" /psig="0.588411588411588" /xcortree=1017 /SigmaFactorBS="aagaaccacagaagtagcggtgagcagggtcttgctcacctt ctttgtGTGTTAaaagaaggccttgaaTAATAAACTAGGAGATGTGaaagatgaacca a" /listShort="trmFO, codV, clpQ, clpY, codY" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1598140..1599447 /gene="trmFO" /locus_tag="BSU_16130" /old_locus_tag="BSU16130" /EC_number="2.1.1.74" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16027442, 21561081, 23095745, 23157377, 27825927, 28745052" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16027442, 21561081, 23095745, 23157377, 27825927, 28745052; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="tRNA:m(5)U-54 methyltransferase" /protein_id="NP_389495.1" /db_xref="EnsemblGenomes-Gn:BSU16130" /db_xref="EnsemblGenomes-Tr:CAB13486" /db_xref="GOA:P39815" /db_xref="InterPro:IPR002218" /db_xref="InterPro:IPR004417" /db_xref="InterPro:IPR020595" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG11008" /db_xref="UniProtKB/Swiss-Prot:P39815" /translation="MNQQTVNVIGAGLAGSEAAWQLAKRGIQVKLYEMRPVKQTPAHH TDKFAELVCSNSLRSNTLANAVGVLKEEMRALDSAIIAAADECSVPAGGALAVDRHEF AASVTNRVKNHPNVTVINEEVTEIPEGPTIIATGPLTSESLSAQLKELTGEDYLYFYD AAAPIVEKDSLDMDKVYLKSRYDKGEAAYLNCPMTEEEFDRFHEALTSAETVPLKEFE KEIFFEGCMPIEVMAKRGKKTMLFGPMKPVGLEHPVTGKRPYAVVQLRQDDAAGTLYN IVGFQTHLKWGDQKEVLKLIPGLENVEIVRYGVMHRNTFINSPSLLKPTYQFKNRSDL FFAGQMTGVEGYVESAASGLVAGINAAKLVLGEELVIFPQETAIGSMAHYITTTNQKN FQPMNANFGLLKELPVKIKNKKERNEQYANRAIETIQTISKTI*" /label="trmFO CDS" gene 1598140..1599447 /gene="trmFO" /locus_tag="BSU_16130" /old_locus_tag="BSU16130" /label="trmFO gene" promotor_-35 1599453..1599457 /Source="Nicolas_upshift_promotors" /id="U1321" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.626373626373626" /psig="0.998001998001998" /xcortree=2482 /SigmaFactorBS="caaacaatttcgaaaacaatataggtattGATTGcaacctga gcgcgattTGTGATACCATTTAAAAGCCcttcctggggaggtattaggcatggagaat g" /listShort="codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD" /listLong="ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1599474..1599493 /Source="Nicolas_upshift_promotors" /id="U1321" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.626373626373626" /psig="0.998001998001998" /xcortree=2482 /SigmaFactorBS="caaacaatttcgaaaacaatataggtattGATTGcaacctga gcgcgattTGTGATACCATTTAAAAGCCcttcctggggaggtattaggcatggagaat g" /listShort="codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD" /listLong="ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" upshifts 1599484 /Source="Nicolas_upshifts" /id="U1321" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.626373626373626" /psig="0.998001998001998" /xcortree=2482 /SigmaFactorBS="caaacaatttcgaaaacaatataggtattGATTGcaacctga gcgcgattTGTGATACCATTTAAAAGCCcttcctggggaggtattaggcatggagaat g" /listShort="codV, clpQ, clpY, codY, S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD" /listLong="ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" CDS 1599515..1600429 /gene="codV" /locus_tag="BSU_16140" /old_locus_tag="BSU16140" /function="16.9: Replicate" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10498718, 11208805, 16553881, 16597952, 21239579" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10498718, 11208805, 16553881, 16597952, 21239579; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="site-specific tyrosine recombinase for chromosome partitioning" /protein_id="NP_389496.1" /db_xref="EnsemblGenomes-Gn:BSU16140" /db_xref="EnsemblGenomes-Tr:CAB13487" /db_xref="GOA:P39776" /db_xref="InterPro:IPR002104" /db_xref="InterPro:IPR004107" /db_xref="InterPro:IPR010998" /db_xref="InterPro:IPR011010" /db_xref="InterPro:IPR011931" /db_xref="InterPro:IPR013762" /db_xref="InterPro:IPR023009" /db_xref="SubtiList:BG10965" /db_xref="UniProtKB/Swiss-Prot:P39776" /translation="MENVKNFVKLFVEYLQIEKNYSQYTIVNYVDSIEEFETFLRVQG INGFEEAAYQDTRIFLTEAYEKGLSRRTISKKISALRSFYKFLMREKLIEENPFQLVH LPKQEKRIPKFLYQKELEELFEVSDISQPAGMRDQALLELLYATGMRVSECCSITIND VDLFMDTVLVHGKGKKQRYIPFGSYAREALKVYMNSGRQCLLMKAKEPHDLLFVNQRG GPLTARGIRHILSGLVQKASSTLHIHPHMLRHTFATHLLNEGADLRSVQELLGHSNLS STQIYTHVSKEMLRNTYMSHHPRAFKKN*" /label="codV CDS" gene 1599515..1600429 /gene="codV" /locus_tag="BSU_16140" /old_locus_tag="BSU16140" /label="codV gene" promotor_-35 1599554..1599558 /Source="Nicolas_upshift_promotors" /id="U1322" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.525474525474525" /psig="0.994005994005994" /xcortree=2472 /SigmaFactorBS="aggcatggagaatgttaagaatttcgtaaagttattcgttga aTATTTacaaattgaaaaaaaTTATTCACAATATACTATTGtgaattatgtggattca a" /listShort="clpQ, clpY, codY, S584" /listLong="flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC" /label="promotor_-35" upshifts 1599571 /Source="Nicolas_upshifts" /id="U1322" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.525474525474525" /psig="0.994005994005994" /xcortree=2472 /SigmaFactorBS="aggcatggagaatgttaagaatttcgtaaagttattcgttga aTATTTacaaattgaaaaaaaTTATTCACAATATACTATTGtgaattatgtggattca a" /listShort="clpQ, clpY, codY, S584" /listLong="flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC" /label="upshifts" promotor_-10 1599574..1599593 /Source="Nicolas_upshift_promotors" /id="U1322" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.525474525474525" /psig="0.994005994005994" /xcortree=2472 /SigmaFactorBS="aggcatggagaatgttaagaatttcgtaaagttattcgttga aTATTTacaaattgaaaaaaaTTATTCACAATATACTATTGtgaattatgtggattca a" /listShort="clpQ, clpY, codY, S584" /listLong="flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC" /label="promotor_-10" CDS 1600442..1600987 /gene="clpQ" /locus_tag="BSU_16150" /old_locus_tag="BSU16150" /EC_number="3.4.25.2" /function="16.6: Maintain" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11179218, 12032294, 12805205, 15983416, 17979190, 18689473, 21546913" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11179218, 12032294, 12805205, 15983416, 17979190, 18689473, 21546913; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="two-component ATP-dependent protease (N-terminalserine protease)" /protein_id="NP_389497.1" /db_xref="EnsemblGenomes-Gn:BSU16150" /db_xref="EnsemblGenomes-Tr:CAB13488" /db_xref="GOA:P39070" /db_xref="InterPro:IPR001353" /db_xref="InterPro:IPR022281" /db_xref="InterPro:IPR023333" /db_xref="InterPro:IPR029055" /db_xref="PDB:1YYF" /db_xref="PDB:2Z3A" /db_xref="PDB:2Z3B" /db_xref="SubtiList:BG10966" /db_xref="UniProtKB/Swiss-Prot:P39070" /translation="MSSFHATTIFAVQHKGRSAMSGDGQVTFGQAVVMKHTARKVRKL FNGKVLAGFAGSVADAFTLFEKFEAKLEEYNGNLKRAAVELAKEWRSDKVLRKLEAML IVMNQDTLLLVSGTGEVIEPDDGILAIGSGGNYALAAGRALKKHAGESMSASEIARAA LETAGEICVYTNDQIILEELE*" /label="clpQ CDS" gene 1600442..1600987 /gene="clpQ" /locus_tag="BSU_16150" /old_locus_tag="BSU16150" /label="clpQ gene" CDS 1601004..1602407 /gene="clpY" /locus_tag="BSU_16160" /old_locus_tag="BSU16160" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11179218, 12032294, 12805205, 15983416, 17979190, 18689473, 21546913" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11179218, 12032294, 12805205, 15983416, 17979190, 18689473, 21546913; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="two-component ATP-dependent protease (ATPase andchaperone)" /protein_id="NP_389498.1" /db_xref="EnsemblGenomes-Gn:BSU16160" /db_xref="EnsemblGenomes-Tr:CAB13489" /db_xref="GOA:P39778" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR003959" /db_xref="InterPro:IPR004491" /db_xref="InterPro:IPR019489" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10967" /db_xref="UniProtKB/Swiss-Prot:P39778" /translation="MEKKPLTPRQIVDRLDQYIVGQQNAKKAVAVALRNRYRRSLLDE KLKDEVVPKNILMMGPTGVGKTEIARRIAKLSGAPFIKIEATKFTEVGYVGRDVESMV RDLVETSVRLIKEEKMNEVKEQAEENANKRIVRLLVPGKKKQSGVKNPFEMFFGGSQP NGEDEAESQEEANIEEKRKRMAHQLALGELEDYYVTVEVEEQQPSMFDMLQGSGMEQM GMNMQDALSGLMPKKKKRRKMTVREARKVLTNEEASKLIDMDEVGQEAVQRAEESGII FIDEIDKIAKNGGASSSADVSREGVQRDILPIVEGSTVVTKYGSVKTDHVLFIAAGAF HMAKPSDLIPELQGRFPIRVELNKLTVDDFVRILVEPDNALLKQYQALLQTEGISLEF SDEAIHKIAEVAYHVNQDTDNIGARRLHTILERLLEDLSFEAPDVTMEKITITPQYVE EKLGTIAKNKDLSQFIL*" /label="clpY CDS" gene 1601004..1602407 /gene="clpY" /locus_tag="BSU_16160" /old_locus_tag="BSU16160" /label="clpY gene" CDS 1602447..1603226 /gene="codY" /locus_tag="BSU_16170" /old_locus_tag="BSU16170" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9515911, 10094682, 10231480, 10803944, 10809682, 16488888, 17993518, 21856856, 24843172, 26473603, 27596595, 28011634" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9515911, 10094682, 10231480, 10803944, 10809682, 16488888, 17993518, 21856856, 24843172, 26473603, 27596595, 28011634; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator, GTP and BCAA-dependent" /protein_id="NP_389499.1" /db_xref="EnsemblGenomes-Gn:BSU16170" /db_xref="EnsemblGenomes-Tr:CAB13490" /db_xref="GOA:P39779" /db_xref="InterPro:IPR010312" /db_xref="InterPro:IPR013198" /db_xref="InterPro:IPR014154" /db_xref="InterPro:IPR029016" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2B0L" /db_xref="PDB:2B18" /db_xref="PDB:2GX5" /db_xref="PDB:2HGV" /db_xref="PDB:5LNH" /db_xref="PDB:5LOE" /db_xref="PDB:5LOJ" /db_xref="PDB:5LOO" /db_xref="SubtiList:BG10968" /db_xref="UniProtKB/Swiss-Prot:P39779" /translation="MALLQKTRIINSMLQAAAGKPVNFKEMAETLRDVIDSNIFVVSR RGKLLGYSINQQIENDRMKKMLEDRQFPEEYTKNLFNVPETSSNLDINSEYTAFPVEN RDLFQAGLTTIVPIIGGGERLGTLILSRLQDQFNDDDLILAEYGATVVGMEILREKAE EIEEEARSKAVVQMAISSLSYSELEAIEHIFEELDGNEGLLVASKIADRVGITRSVIV NALRKLESAGVIESRSLGMKGTYIKVLNNKFLIELENLKSH*" /label="codY CDS" gene 1602447..1603226 /gene="codY" /locus_tag="BSU_16170" /old_locus_tag="BSU16170" /label="codY gene" downshifts 1603201 /Source="Nicolas_upshifts" /id="D893" /incds=0 /nref=6 /ntot=130 /MaxReadThrough="5.35492" /MaxDrop="5.90286" /score="-6.99307778" /energy="-4.2" /TU="U1321,U1322" /idTUdmin="U1320" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 1603245 /Source="Nicolas_upshifts" /id="D894" /incds=0 /nref=1 /ntot=104 /MaxReadThrough="4.95658" /MaxDrop="4.85551" /score="-6.99307778" /energy="-4.2" /TU="U1321,U1322" /idTUdmin="U1320" /TUdmin=44 /isTUend="FALSE" /label="downshifts" promotor_-35 1603346..1603353 /Source="Nicolas_upshift_promotors" /id="U1323" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2824 /SigmaFactorBS="gtaataattttaataaattttgcatttttCTTCAAAAagttt caaaaatGCCGAAAAGAAAGGAGAAAaaacagaaattctgctattttcaggcttatat c" /listShort="S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL" /listLong="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1603366..1603384 /Source="Nicolas_upshift_promotors" /id="U1323" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2824 /SigmaFactorBS="gtaataattttaataaattttgcatttttCTTCAAAAagttt caaaaatGCCGAAAAGAAAGGAGAAAaaacagaaattctgctattttcaggcttatat c" /listShort="S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL" /listLong="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" S_feature 1603377..1603530 /Source="Nicolas_S_feature" /locus_tag="new_1691049_1691202" /HighExp="C30, GM 90, GM 25, Cold, GM 15, GM 10, MG 150, GM-0.2, LBGstat, GM-0.1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigA, SigA" /TUshortPSig="1, 0.994, 0.998" /TUlongSig="SigA, SigA, SigD, SigA, SigA" /TUlongPSig="1, 0.999, 1, 1, 1" /label="S584" upshifts 1603377 /Source="Nicolas_upshifts" /id="U1323" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2824 /SigmaFactorBS="gtaataattttaataaattttgcatttttCTTCAAAAagttt caaaaatGCCGAAAAGAAAGGAGAAAaaacagaaattctgctattttcaggcttatat c" /listShort="S584, flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL" /listLong="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" promotor_-35 1603505..1603512 /Source="Nicolas_upshift_promotors" /id="U1324" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.748251748251748" /psig="0.998001998001998" /xcortree=2791 /SigmaFactorBS="gataattgtgaggacatttttttacacgaacttCATAGACTt tatgcctgttattTCTTACAATAAGCATATAGTtttacaattctcgacaaggatattg a" /listShort="flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1603527..1603546 /Source="Nicolas_upshift_promotors" /id="U1324" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.748251748251748" /psig="0.998001998001998" /xcortree=2791 /SigmaFactorBS="gataattgtgaggacatttttttacacgaacttCATAGACTt tatgcctgttattTCTTACAATAAGCATATAGTtttacaattctcgacaaggatattg a" /listShort="flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" upshifts 1603532 /Source="Nicolas_upshifts" /id="U1324" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.748251748251748" /psig="0.998001998001998" /xcortree=2791 /SigmaFactorBS="gataattgtgaggacatttttttacacgaacttCATAGACTt tatgcctgttattTCTTACAATAAGCATATAGTtttacaattctcgacaaggatattg a" /listShort="flgB, flgC, fliE, fliF, fliG, S585, fliH, fliI, fliJ, ylxF, fliK, flgD, flgE, ylzI, fliL, fliM, fliY, cheY, fliZ, fliP, fliQ, fliR, flhB, flhA, flhF, ylxH, cheB, cheA, cheW, cheC, cheD, sigD, ylxL, S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" CDS 1603606..1603995 /gene="flgB" /locus_tag="BSU_16180" /old_locus_tag="BSU16180" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1905667, 2129540, 2181149, 9657996, 17850253, 25843804; Product type s: structure" /codon_start=1 /transl_table=11 /product="flagellar component of cell-proximal portion of basal-body rod" /protein_id="NP_389500.1" /db_xref="EnsemblGenomes-Gn:BSU16180" /db_xref="EnsemblGenomes-Tr:CAB13491" /db_xref="GOA:P24500" /db_xref="InterPro:IPR001444" /db_xref="InterPro:IPR006300" /db_xref="InterPro:IPR019776" /db_xref="SubtiList:BG10237" /db_xref="UniProtKB/Swiss-Prot:P24500" /translation="MSLFSGTIQNLENALSRADIKQKVITNNIANIDTPNYKAKKVSF QNLLDQESSRLEAIKTDYRHVDFSDTDSNYSIVASGDTSYQQNGNNVDVDKEMTELAQ NQINYQALVERMNGKFNSLKTVLTGGK*" /label="flgB CDS" gene 1603606..1603995 /gene="flgB" /locus_tag="BSU_16180" /old_locus_tag="BSU16180" /label="flgB gene" CDS 1603995..1604447 /gene="flgC" /locus_tag="BSU_16190" /old_locus_tag="BSU16190" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1905667, 2129540, 2181149, 9657996; Product type s: structure" /codon_start=1 /transl_table=11 /product="flagellar component of cell-proximal portion of basal-body rod" /protein_id="NP_389501.1" /db_xref="EnsemblGenomes-Gn:BSU16190" /db_xref="EnsemblGenomes-Tr:CAB13492" /db_xref="GOA:P24501" /db_xref="InterPro:IPR001444" /db_xref="InterPro:IPR006299" /db_xref="InterPro:IPR010930" /db_xref="InterPro:IPR019776" /db_xref="SubtiList:BG10238" /db_xref="UniProtKB/Swiss-Prot:P24501" /translation="MTAFHSLNVSASALTAQRVRMDVVSSNLANMDTTRAKQVNGEWV PYRRKMVSLQSKGESFSSILNSQMSGSGNAGNGVKVSKITEDDSDFNLVYDPTDPDAN AEGYVQKPNVDPLKEMVDLVSSTRSYEANVTAMNATKGMLMKALEIGK*" /label="flgC CDS" gene 1603995..1604447 /gene="flgC" /locus_tag="BSU_16190" /old_locus_tag="BSU16190" /label="flgC gene" CDS 1604458..1604778 /gene="fliE" /locus_tag="BSU_16200" /old_locus_tag="BSU16200" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11133968, 1551848, 1905667, 2544561, 9161424, 11133968, 15136044; Product type s: structure" /codon_start=1 /transl_table=11 /product="flagellar basal body protein" /protein_id="NP_389502.1" /db_xref="EnsemblGenomes-Gn:BSU16200" /db_xref="EnsemblGenomes-Tr:CAB13493" /db_xref="GOA:P24502" /db_xref="InterPro:IPR001624" /db_xref="SubtiList:BG10239" /db_xref="UniProtKB/Swiss-Prot:P24502" /translation="MINAISPFQVQNTQNTQNATNQVNNSQKTDSSNQTSFSELLKNS ISSLNESQVASDNMTNALAAGKDVNLDEVMIAAQKASISLTAATEFRNKAVEAYQEIM RMQM*" /label="fliE CDS" gene 1604458..1604778 /gene="fliE" /locus_tag="BSU_16200" /old_locus_tag="BSU16200" /label="fliE gene" downshifts complement(1604773) /Source="Nicolas_upshifts" /id="D895" /incds=0 /nref=1 /ntot=83 /MaxReadThrough="1.38909" /MaxDrop="2.66249" /score="0.0645368779" /energy="-7.4" /TU="NA" /idTUdmin="U1325" /TUdmin=2684 /isTUend="FALSE" /label="downshifts" CDS 1604824..1606434 /gene="fliF" /locus_tag="BSU_16210" /old_locus_tag="BSU16210" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1551848, 1905667, 2544561, 9161424, 11133968, 22670715, 24970213, 28089452; Product type s: structure" /codon_start=1 /transl_table=11 /product="flagellar basal-body M-ring protein" /protein_id="NP_389503.1" /db_xref="EnsemblGenomes-Gn:BSU16210" /db_xref="EnsemblGenomes-Tr:CAB13494" /db_xref="GOA:P23447" /db_xref="InterPro:IPR000067" /db_xref="InterPro:IPR006182" /db_xref="InterPro:IPR013556" /db_xref="InterPro:IPR021157" /db_xref="SubtiList:BG10240" /db_xref="UniProtKB/Swiss-Prot:P23447" /translation="MNRTLMQMKNKTSEFWKNRSKLQKILMVSALAAIIIIGIIISVF ASNSKMAPLYKDLSAEEAGQIKEELDAKKVPNELSNGGTVISVPEDQVDSLKVQMAAE GLPKTGSIDYSFFGQNAGFGLTDNEFDMVKVKATQTELSNLINEMDGIKNSKVMINLP KDAVFVGEEQSAASASIVLQIQPGYTLDQSQINGLYHLVSKSVPNLKEDNIVIMDQNS TYYDKSDSDAGSYADSYSSQQGIKSQVEKDIQKHVQSLLGTMMGQDKVVVSVTADIDF TKENRTEDIVEPVDKENMEGIAVSAEKVSETYQGDGAANGGTAGTGEEDVTNYKADGE NTESGNYEKNSNKINYEVNRIHKEIAESPYKVRDLGIQVMVEPPDAKNTASLSTERQD DIQKILSTVVRTSLDKDETQNQNLSDADINNKIVVSVQPFDGKVNLDTNTEESSGIPL WAYIVGGVLIAAIIVLIIMLIRKKRAQEDEFEEYEYEVPQEPINLPDINEEENETAES VRRKQLEKMAKDKPEDFAKLLRSWLAED*" /label="fliF CDS" gene 1604824..1606434 /gene="fliF" /locus_tag="BSU_16210" /old_locus_tag="BSU16210" /label="fliF gene" CDS 1606447..1607463 /gene="fliG" /locus_tag="BSU_16220" /old_locus_tag="BSU16220" /function="16.5: Explore" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1551848, 1905667, 2544561, 9161424, 10440379, 11133968, 28089452; Product type s : structure" /codon_start=1 /transl_table=11 /product="flagellar motor switching and energizing component" /protein_id="NP_389504.1" /db_xref="EnsemblGenomes-Gn:BSU16220" /db_xref="EnsemblGenomes-Tr:CAB13495" /db_xref="GOA:P23448" /db_xref="InterPro:IPR000090" /db_xref="InterPro:IPR011002" /db_xref="InterPro:IPR023087" /db_xref="InterPro:IPR028263" /db_xref="InterPro:IPR032779" /db_xref="SubtiList:BG10241" /db_xref="UniProtKB/Swiss-Prot:P23448" /translation="MARRDQDKLTGKQKAAILMISLGLDVSASVYKHLTDEEIERLTL EISGVRSVDHQKKDEIIEEFHNIAIAQDYISQGGLSYARQVLEKALGEDKAENILNRL TSSLQVKPFDFARKAEPEQILNFIQQEHPQTMALILSYLDPVQAGQILSELNPEVQAE VARRIAVMDRTSPEIINEVERILEQKLSSAFTQDYTQTGGIEAVVEVLNGVDRGTEKT ILDSLEIQDPDLAEEIKKRMFVFEDIVTLDNRAIQRVIRDVENDDLLLSLKVASEEVK EIVFNNMSQRMVETFKEEMEFMGPVRLKDVEEAQSRIVSIVRKLEEAGEIVIARGGGD DIIV*" /label="fliG CDS" gene 1606447..1607463 /gene="fliG" /locus_tag="BSU_16220" /old_locus_tag="BSU16220" /label="fliG gene" S_feature 1607464..1607581 /Source="Nicolas_S_feature" /locus_tag="new_1695136_1695253" /HighExp="Lbstat, C90, M0t90, M40t90, Lbtran, C30, LPhT, GM 90, M40t45, GM-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD, SigA" /TUshortPSig="0.998, 1, 0.998" /TUlongSig="SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.994, 1, 0.999, 1, 1, 1" /label="S585" promotor_no_box complement(1607527..1607627) /Source="Nicolas_upshift_promotors" /id="U1325" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.937062937062937" /psig="0.00999000999001" /xcortree=81 /SigmaFactorBS="ttgcctgctcagaaatccggtcagcttcctctttcactcggg ccataagcgcctccgggttctcttcagcctgcaaaaggtgagaatgatcaatacgcac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1607567) /Source="Nicolas_upshifts" /id="U1325" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.937062937062937" /psig="0.00999000999001" /xcortree=81 /SigmaFactorBS="ttgcctgctcagaaatccggtcagcttcctctttcactcggg ccataagcgcctccgggttctcttcagcctgcaaaaggtgagaatgatcaatacgcac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 1607582..1608208 /gene="fliH" /locus_tag="BSU_16230" /old_locus_tag="BSU16230" /function="16.6: Maintain" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1828465, 12217691, 16522800, 17002279, 26916245; Product type f: factor" /codon_start=1 /transl_table=11 /product="flagellar export apparatus subunit of cytoplasmic ATPase" /protein_id="NP_389505.2" /db_xref="EnsemblGenomes-Gn:BSU16230" /db_xref="EnsemblGenomes-Tr:CAB13496" /db_xref="GOA:P23449" /db_xref="InterPro:IPR018035" /db_xref="InterPro:IPR022524" /db_xref="SubtiList:BG10242" /db_xref="UniProtKB/Swiss-Prot:P23449" /translation="MARVKEEADRISEQANSHIENIRRQIEQEKNDWAAEKQKLIEEA KAEGFEQGVALGKAEAMKQYAELIGQANSITEMSRKAVEDKLEDANEEIVELAVALAK KVWQQKSDDKEAFLLLVQQVINEVKEYDDISIYVDPYYYETIFQQKDEIQQLLYKECR LGIYADEKAQKGTCYIETPFGRVDASVDTQLMQLKDKLLTALEAGAAE*" /label="fliH CDS" gene 1607582..1608208 /gene="fliH" /locus_tag="BSU_16230" /old_locus_tag="BSU16230" /label="fliH gene" CDS 1608205..1609521 /gene="fliI" /locus_tag="BSU_16240" /old_locus_tag="BSU16240" /EC_number="3.6.3.14" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12787361, 16113269, 16780875, 17002279, 26916245; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="flagellar-specific ATPase subunit of export apparatus" /protein_id="NP_389506.2" /db_xref="EnsemblGenomes-Gn:BSU16240" /db_xref="EnsemblGenomes-Tr:CAB13497" /db_xref="GOA:P23445" /db_xref="InterPro:IPR000194" /db_xref="InterPro:IPR000225" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004100" /db_xref="InterPro:IPR005714" /db_xref="InterPro:IPR020003" /db_xref="InterPro:IPR022425" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR032463" /db_xref="SubtiList:BG10243" /db_xref="UniProtKB/Swiss-Prot:P23445" /translation="MKTQSLIDCIEMTDSYKRYGKVKRVIGLMIESKGPASSIGDLCL IYAKGQSGKVIKAEVVGFQEENILLMPYLEAASIAPGSIVEATGESLRVKVGTGLIGQ VIDAFGEPLDGKLLPKGLSPVSTEQSPPNPMKRPPIREKMGVGVRSIDSLLTVGKGQR IGIFAGSGVGKSTLMGMIAKQTEADLNVIALVGERGREVREFIEKDLGKEGLKRSIVV VATSDQPALMRLKAAYTATAIAEYFRDKGQNVMFMMDSVTRVAMAQREIGLAAGEPPT TKGYTPSVFAILPRLLERTGANEHGTITAFYTVLVDGDDMNEPIADTVRGILDGHIVL DRALANKGQFPAVNVLKSISRVMSNISTKQHLDAANKFRELLSTYQNSEDLINIGAYK RGSSREIDEAIQFYPQLIQFLKQGTDEPALLEESIAALTSLTGNEE*" /label="fliI CDS" gene 1608205..1609521 /gene="fliI" /locus_tag="BSU_16240" /old_locus_tag="BSU16240" /label="fliI gene" CDS 1609524..1609967 /gene="fliJ" /locus_tag="BSU_16250" /old_locus_tag="BSU16250" /function="16.13: Shape" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17088562, 26916245, 26984495, 27647891; Product type f: factor" /codon_start=1 /transl_table=11 /product="flagellar synthesis rod subunit of export ATPase" /protein_id="NP_389507.1" /db_xref="EnsemblGenomes-Gn:BSU16250" /db_xref="EnsemblGenomes-Tr:CAB13498" /db_xref="GOA:P20487" /db_xref="InterPro:IPR012823" /db_xref="SubtiList:BG10245" /db_xref="UniProtKB/Swiss-Prot:P20487" /translation="MAYQFRFQKLLELKENEKDQSLSEYQQSVSEFENVAEKLYENMS KKELLEQNKEKKLKSGMSVQEMRHYQQFVSNLDNTIYHYQKLVIMKRNQMNQKQEILT EKNIEVKKFEKMREKQFKMFALEDKAAEMKEMDDISIKQFMIQGH*" /label="fliJ CDS" gene 1609524..1609967 /gene="fliJ" /locus_tag="BSU_16250" /old_locus_tag="BSU16250" /label="fliJ gene" CDS 1609979..1610593 /gene="ylxF" /locus_tag="BSU_16260" /old_locus_tag="BSU16260" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17586671, 22307758; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative kinesin-like protein" /protein_id="NP_389508.2" /db_xref="EnsemblGenomes-Gn:BSU16260" /db_xref="EnsemblGenomes-Tr:CAB13499" /db_xref="GOA:P23454" /db_xref="InterPro:IPR006668" /db_xref="InterPro:IPR011002" /db_xref="SubtiList:BG10246" /db_xref="UniProtKB/Swiss-Prot:P23454" /translation="MSGKKKESGKFRSVLLIIILPLMFLLIAGGIVLWAAGINVLKPI QDAAAKTPVLKELVPETENKKGAASSKDSSNTAALEKTIKDQKSEISILNKDLETSKS EIDRLNQKIRSLEKTAEDQKKSSEDHTEGSADSKASSENDKVISVYKSMDSGKAAKII AQLKEQEALKILNGLSKKQLADILAKMTPEQAATYTEKIAASQE*" /label="ylxF CDS" gene 1609979..1610593 /gene="ylxF" /locus_tag="BSU_16260" /old_locus_tag="BSU16260" /label="ylxF gene" CDS 1610606..1612069 /gene="fliK" /locus_tag="BSU_16270" /old_locus_tag="BSU16270" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16630628, 16949608, 28557186; Product type f: factor" /codon_start=1 /transl_table=11 /product="flagellar hook-length control protein (ruler)" /protein_id="NP_389509.2" /db_xref="EnsemblGenomes-Gn:BSU16270" /db_xref="EnsemblGenomes-Tr:CAB13500" /db_xref="GOA:P23451" /db_xref="InterPro:IPR001635" /db_xref="InterPro:IPR021136" /db_xref="SubtiList:BG10247" /db_xref="UniProtKB/Swiss-Prot:P23451" /translation="MKLLELAGPLLQTTTGSAAKNMKSSQGVFQNWLMSEAGLKELSE QGKGTPNSEDQLLADALKKIGEWLNASPEDQDKQNADLLQTLSKLTGKQLDANALQML QNLLQAVESKMSGGTDQLLTETEKIFSEAKTALSANDSASDINGALKSDKEQSNQENE VSEPAKELIYIQMFISQLVEGNKLTDLGNGNEAHAIYQNGDQFLSALEKKGVSQQLIQ DLKQQIFTKAESSSKLYSMTASELKSFQSLMDQMSMLPQKGTKEWSLAESQLKAFLLS KSSESSQDFGKSVLTPLSQSSSSKNASDVSGSIQPVDSKSGLQMLFSGYRGIGGVQTL DLQQMSSDIPNAETKTVADQVINAWKQMKYTPFGRSTGSFTIRLNPEHLGFVTIKLTN ENGMFQSKIIASSQSAKELLEQHLPQLKQSLPNMAVQIDRFTLPVQSGDQPIYGQLAD EQKQQQEGQRQQRQKKQSNDFGDLLDEVSMVEMEEEE*" /label="fliK CDS" gene 1610606..1612069 /gene="fliK" /locus_tag="BSU_16270" /old_locus_tag="BSU16270" /label="fliK gene" CDS 1612066..1612488 /gene="flgD" /locus_tag="BSU_16280" /old_locus_tag="BSU16280" /function="16.13: Shape" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8157595, 14563871, 24748615; Product type f: factor" /codon_start=1 /transl_table=11 /product="flagellar hook capping protein" /protein_id="NP_389510.1" /db_xref="EnsemblGenomes-Gn:BSU16280" /db_xref="EnsemblGenomes-Tr:CAB13501" /db_xref="GOA:P23455" /db_xref="InterPro:IPR005648" /db_xref="SubtiList:BG10248" /db_xref="UniProtKB/Swiss-Prot:P23455" /translation="MTSISSEYKLPEKTNTVSTNNSSLGKDEFLKILMTQVQNQDPLN PIDDKEFISQMATFSSLEQMMNLNTTMTQFVENQDPFTTYVDWMGKEVSWTDGKSATD KTGTVSSVKHFKGNYYLVLDDGTEISPANVMSVGQSSK*" /label="flgD CDS" gene 1612066..1612488 /gene="flgD" /locus_tag="BSU_16280" /old_locus_tag="BSU16280" /label="flgD gene" CDS 1612510..1613304 /gene="flgE" /locus_tag="BSU_16290" /old_locus_tag="BSU16290" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15502333, 15510139, 27759043, 28120828, 28429800; Product type f: factor" /codon_start=1 /transl_table=11 /product="flagellar hook protein" /protein_id="NP_389511.2" /db_xref="EnsemblGenomes-Gn:BSU16290" /db_xref="EnsemblGenomes-Tr:CAB13502" /db_xref="GOA:P23446" /db_xref="InterPro:IPR001444" /db_xref="InterPro:IPR010930" /db_xref="InterPro:IPR012836" /db_xref="InterPro:IPR019776" /db_xref="InterPro:IPR020013" /db_xref="SubtiList:BG10249" /db_xref="UniProtKB/Swiss-Prot:P23446" /translation="MLRSLYSGISGMKNFQTKLDVIGNNIANVNTVGFKKSRVTFKDM VSQTIAGGSAAGATIGGTNSKQIGLGSSSGTIDTIHSTSATQSTGRTLDLAIDGDGYF RIDTGDGTAYTRAGNFYLDNTGTLVTGDGYHVLNMNGGTIKIPTDAQSFSIGSDGKVS IVDAEGKTQDGGQIGIVTFANSDGLDKIGSNLYRESLNSGTASAANQPGDGGTGALKS GFLEMSNVDLTDEFTEMIVAQRGFQSNSKIITTSDEILQELVNLKR*" /label="flgE CDS" gene 1612510..1613304 /gene="flgE" /locus_tag="BSU_16290" /old_locus_tag="BSU16290" /label="flgE gene" CDS 1613344..1613559 /gene="swrD" /locus_tag="BSU_16299" /old_locus_tag="BSU16299" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9168127, 29061663" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9168127, 29061663; Product type f: factor" /codon_start=1 /transl_table=11 /product="flagellar power transducer required for swarming" /protein_id="YP_003097728.1" /db_xref="EnsemblGenomes-Gn:BSU16299" /db_xref="EnsemblGenomes-Tr:CAX52619" /db_xref="InterPro:IPR009384" /db_xref="UniProtKB/Swiss-Prot:C0H412" /translation="MIKVTRLNGQPFTLNALFIEQIECFPDTTITLSNGKKFVVKEDE EAVLEKIAAFYRKIQIFAMDQGIEEPE*" /label="swrD CDS" gene 1613344..1613559 /gene="swrD" /locus_tag="BSU_16299" /old_locus_tag="BSU16299" /label="swrD gene" CDS 1613556..1613978 /gene="fliL" /locus_tag="BSU_16300" /old_locus_tag="BSU16300" /function="16.5: Explore" /function="16.12: Sense" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10439416, 12787361, 16166542, 23264580, 25714720, 28717192; Product type f : factor" /codon_start=1 /transl_table=11 /product="flagellar basal-body (stator) associated protein" /protein_id="NP_389512.1" /db_xref="EnsemblGenomes-Gn:BSU16300" /db_xref="EnsemblGenomes-Tr:CAB13503" /db_xref="GOA:P23452" /db_xref="InterPro:IPR005503" /db_xref="SubtiList:BG10250" /db_xref="UniProtKB/Swiss-Prot:P23452" /translation="MKKKLMIILLIILIVIGALGAAAYFVLGGKSEKSEAKKSIDEIV ASSVDVEEITTNLKSDNIIRLAIKLETDSDKSKEELEKRDFQVKDAVISLLADTNADQ IEGDKGKETFKKELKDKINSYLQEGKVEKVYITSFNLQ*" /label="fliL CDS" gene 1613556..1613978 /gene="fliL" /locus_tag="BSU_16300" /old_locus_tag="BSU16300" /label="fliL gene" CDS 1614012..1615010 /gene="fliM" /locus_tag="BSU_16310" /old_locus_tag="BSU16310" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7787061, 16547037, 16796690, 16882724, 17015643, 17050923, 22720735, 28625846; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="flagellar motor switching and energizing component" /protein_id="NP_389513.1" /db_xref="EnsemblGenomes-Gn:BSU16310" /db_xref="EnsemblGenomes-Tr:CAB13504" /db_xref="GOA:P23453" /db_xref="InterPro:IPR001543" /db_xref="InterPro:IPR001689" /db_xref="InterPro:IPR028976" /db_xref="InterPro:IPR036429" /db_xref="SubtiList:BG10251" /db_xref="UniProtKB/Swiss-Prot:P23453" /translation="MSGEVLSQNEIDALLSAISTGEMDAEELKKEEKEKKVKVYDFKR ALRFSKDQIRSLTRIHDNFARLLTTHFSAQLRTYIHISVSSVDQVPYEEFIRSIPNMT ILNLFDVHPMEGRIMMEVNPTIAYTMMDRVMGGIGISHNKVDSLTEIETKIISNLFEN ALGNYKEAWQSIADIEPEMTEFEVNPQFVQMVSPNETVVVISLNTQIGEISGVINLCI PHIVLEPLIPKLSVHYWMQSDRNEPKPEETKSLEKRIMTAQIPVVAELGTSELTIEEF LSLEVGDCITLDKSVTDPLTVLVGDKPKFLGQAGRVNRKQAVQILDHDIRGEQDGE*" /label="fliM CDS" gene 1614012..1615010 /gene="fliM" /locus_tag="BSU_16310" /old_locus_tag="BSU16310" /label="fliM gene" CDS 1615000..1616136 /gene="fliY" /locus_tag="BSU_16320" /old_locus_tag="BSU16320" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12920116, 16547037, 16796690, 16882724, 17015643, 17050923, 23226535, 23532838, 26195616" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12920116, 16547037, 16796690, 16882724, 17015643, 17050923, 23226535, 23532838, 26195616; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="flagellar motor switching and energizing phosphatase" /protein_id="NP_389514.1" /db_xref="EnsemblGenomes-Gn:BSU16320" /db_xref="EnsemblGenomes-Tr:CAB13505" /db_xref="GOA:P24073" /db_xref="InterPro:IPR001172" /db_xref="InterPro:IPR001543" /db_xref="InterPro:IPR007597" /db_xref="InterPro:IPR012826" /db_xref="InterPro:IPR028976" /db_xref="InterPro:IPR036429" /db_xref="SubtiList:BG10252" /db_xref="UniProtKB/Swiss-Prot:P24073" /translation="MENNRLSQDEIDALLNGTGSTLDEPEIPEVDDLSEMERDAIGEI GNISFGSSATALSTLLNQKVDITTPSVTVIPRSKISDAFPEPYVAIEVNYTEGFSGSN LLVVEQSDAAIIADLMIGGDGKGADPSLGEIHLSAVQEAMNQMMGSAATSMSTVFSKK IDISPPRVELLDVTEEKGTDRIPDDEMLVKVSFNLKVGELIDSSIMQLYPLTFAKDLI SSLMNSESAEEEETVQPEVTYEQPKEPVTPEPRIEPKQQQQPPKRQGTAKKAAPVQVS PVEFSAFDPNEAVQAPIHNLDMLLDIPLSITVELGRTKRSVKEILELSAGSIIELDKL AGEPVDILVNQRIVAKGEVVVIEENFGVRVTDILSQAERINNLK*" /label="fliY CDS" gene 1615000..1616136 /gene="fliY" /locus_tag="BSU_16320" /old_locus_tag="BSU16320" /label="fliY gene" CDS 1616162..1616524 /gene="cheY" /locus_tag="BSU_16330" /old_locus_tag="BSU16330" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10196193, 12864845, 12920116, 14749334, 23226535, 28542702" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10196193, 12864845, 12920116, 14749334, 23226535, 28542702; Product type r : regulator" /codon_start=1 /transl_table=11 /product="regulator of chemotaxis and motility" /protein_id="NP_389515.1" /db_xref="EnsemblGenomes-Gn:BSU16330" /db_xref="EnsemblGenomes-Tr:CAB13506" /db_xref="GOA:P24072" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="SubtiList:BG10258" /db_xref="UniProtKB/Swiss-Prot:P24072" /translation="MAHRILIVDDAAFMRMMIKDILVKNGFEVVAEAENGAQAVEKYK EHSPDLVTMDITMPEMDGITALKEIKQIDAQARIIMCSAMGQQSMVIDAIQAGAKDFI VKPFQADRVLEAINKTLN*" /label="cheY CDS" gene 1616162..1616524 /gene="cheY" /locus_tag="BSU_16330" /old_locus_tag="BSU16330" /label="cheY gene" CDS 1616539..1617198 /gene="fliZ" /locus_tag="BSU_16340" /old_locus_tag="BSU16340" /function="16.3: Control" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10791024, 1597417, 16513753, 24204316; Product type r: regulator" /codon_start=1 /transl_table=11 /product="flagellar regulatory protein" /protein_id="NP_389516.1" /db_xref="EnsemblGenomes-Gn:BSU16340" /db_xref="EnsemblGenomes-Tr:CAB13507" /db_xref="GOA:P35536" /db_xref="InterPro:IPR022781" /db_xref="SubtiList:BG10259" /db_xref="UniProtKB/Swiss-Prot:P35536" /translation="MKKSQYFIVFICFFVLFSVHPIAAAAADSDNSTVNEWFQKKDEK TADQSEQKKEKTTKTADETEGAAAPSVSAFDFVKMIFALLFVIVLIYGLVKLMNKRNR LLKPFQYVENIGGTSVGQNRSIQLIKVGKSVLVVGVGETIQLLKEIEDEKEIEVILSQ HEEAMSSKIEWQKFVKPLKSSEHQPQQKLPSFSKALKEQLEELKQNRSEGKKKGPRHH E*" /label="fliZ CDS" gene 1616539..1617198 /gene="fliZ" /locus_tag="BSU_16340" /old_locus_tag="BSU16340" /label="fliZ gene" CDS 1617191..1617856 /gene="fliP" /locus_tag="BSU_16350" /old_locus_tag="BSU16350" /function="16.3: Control" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15516571, 15849754, 16850406, 22720735, 26244495, 27855178, 28559296; Product type t: transporter" /codon_start=1 /transl_table=11 /product="component of the flagellar export machinery" /protein_id="NP_389517.1" /db_xref="EnsemblGenomes-Gn:BSU16350" /db_xref="EnsemblGenomes-Tr:CAB13508" /db_xref="GOA:P35528" /db_xref="InterPro:IPR005837" /db_xref="InterPro:IPR005838" /db_xref="SubtiList:BG10260" /db_xref="UniProtKB/Swiss-Prot:P35528" /translation="MNEFINIFSSSDPENVSSTVKLLLLLTVFSVAPGILILMTCFTR IVIVLSFVRTSLATQSMPPNQVLIGLALFLTFFIMAPTFSEINKEALTPLMDNKISLD EAYTKAEEPIKEFMSKHTRQKDLALFMNYAKMDKPESLKDIPLTTMVPAFAISELKTA FQIGFMIFIPFLIIDMVVASVLMSMGMMMLPPVMISLPFKILLFVLVDGWYLIVKSLL QSF*" /label="fliP CDS" gene 1617191..1617856 /gene="fliP" /locus_tag="BSU_16350" /old_locus_tag="BSU16350" /label="fliP gene" CDS 1617871..1618140 /gene="fliQ" /locus_tag="BSU_16360" /old_locus_tag="BSU16360" /function="16.5: Explore" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10234819, 15516571, 27855178; Product type t: transporter" /codon_start=1 /transl_table=11 /product="component of the flagellar export machinery" /protein_id="NP_389518.1" /db_xref="EnsemblGenomes-Gn:BSU16360" /db_xref="EnsemblGenomes-Tr:CAB13509" /db_xref="GOA:P35535" /db_xref="InterPro:IPR002191" /db_xref="InterPro:IPR006305" /db_xref="SubtiList:BG10261" /db_xref="UniProtKB/Swiss-Prot:P35535" /translation="MSSEFVISMAEKAVYVTLMISGPLLAIALLVGLIVSIFQATTQI QEQTLAFIPKIVAVLLALIFFGPWMLSTILSFTTELFSNLNRFAG*" /label="fliQ CDS" gene 1617871..1618140 /gene="fliQ" /locus_tag="BSU_16360" /old_locus_tag="BSU16360" /label="fliQ gene" CDS 1618148..1618927 /gene="fliR" /locus_tag="BSU_16370" /old_locus_tag="BSU16370" /function="16.5: Explore" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15060055, 15516571, 15849754, 16850406, 28771474; Product type t : transporter" /codon_start=1 /transl_table=11 /product="component of the flagellar export machinery" /protein_id="NP_389519.2" /db_xref="EnsemblGenomes-Gn:BSU16370" /db_xref="EnsemblGenomes-Tr:CAB13510" /db_xref="GOA:P35537" /db_xref="InterPro:IPR002010" /db_xref="InterPro:IPR006303" /db_xref="SubtiList:BG10262" /db_xref="UniProtKB/Swiss-Prot:P35537" /translation="MNSIIDLFPAFLLVFIRISAFFVTIPLFGHRNVPAVHRIGFAFF LAVICFSTIDKPPSLEIDEHYMLLAFKEALVGLCLGLIAYMMIAAVQIAGSFIDFQMG FSIANVIDPQTGAQSPLIGQFIYTMALLFMLSVNAHHLLLDGIYYSFQYISVDQAFPN FGDEKFAYFIAKSFNAMFIIAFQMSAPVVASLFLVDLALGIVARTVPQLNVFVVGLPL KIAVSFIMLIVCMSVIFVVVRNVFSLTIETMRNLLALVGVS*" /label="fliR CDS" gene 1618148..1618927 /gene="fliR" /locus_tag="BSU_16370" /old_locus_tag="BSU16370" /label="fliR gene" CDS 1618927..1620009 /gene="flhB" /locus_tag="BSU_16380" /old_locus_tag="BSU16380" /function="16.1: Circulate" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10234819, 16949608, 17050924, 17067800, 28557186, 28771466; Product type t : transporter" /codon_start=1 /transl_table=11 /product="component of the flagellar export machinery" /protein_id="NP_389520.1" /db_xref="EnsemblGenomes-Gn:BSU16380" /db_xref="EnsemblGenomes-Tr:CAB13511" /db_xref="GOA:P35538" /db_xref="InterPro:IPR006135" /db_xref="InterPro:IPR006136" /db_xref="InterPro:IPR029025" /db_xref="SubtiList:BG10543" /db_xref="UniProtKB/Swiss-Prot:P35538" /translation="MKLRVDLQFFAGEKTEKATPKKRKDTRKKGQVAKSSDVNTAVSL LVIFLSLIAIGPYMRDRLLSFIETFYTESLTMKLSESNVHTLFVSLLKDMGMILAPIL LVALVAGVVSNYMQVGFLFSAEVIQPKLEKLDPIKGFKRIYSMRAIVELIKSILKIVV VGFAAFAVLWLHYGEILRLPLLTPEEALSFVSKLTLWMGLSGAGALLILAGLDYLYQR FDYEKNIKMSKQDIKDEYKKSEGDPIIKSKIKQRQREMAMRRMMQEVPKADVIITNPT HYAIALKYDEEKMDAPYIVAKGVDHLALKIRKIAKEHDVMMVENRPLARALYDQVEID QAVPEEFFKVLAEILAYVYKTKQKVY*" /label="flhB CDS" gene 1618927..1620009 /gene="flhB" /locus_tag="BSU_16380" /old_locus_tag="BSU16380" /label="flhB gene" CDS 1620042..1622075 /gene="flhA" /locus_tag="BSU_16390" /old_locus_tag="BSU16390" /function="16.1: Circulate" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10234819, 15516571, 20534509, 28771466" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10234819, 15516571, 20534509, 28771466; Product type f: factor" /codon_start=1 /transl_table=11 /product="component of the flagellar export machinery" /protein_id="NP_389521.2" /db_xref="EnsemblGenomes-Gn:BSU16390" /db_xref="EnsemblGenomes-Tr:CAB13512" /db_xref="GOA:P35620" /db_xref="InterPro:IPR001712" /db_xref="InterPro:IPR006301" /db_xref="InterPro:IPR025505" /db_xref="PDB:3MIX" /db_xref="SubtiList:BG10542" /db_xref="UniProtKB/Swiss-Prot:P35620" /translation="MSTRDLSVLISVVLIVAMLVIPFPPWLLSILIIINISLALIVLL TTMNMQEALQFSIFPSLLLLLTLFRLGLNVSTTRSILSHGEGGKVVETFGNFVVGGNV LVGLVVFIILIIIQFIVITKGAERVSEVAARFTLDAMPGKQMSIDADLNAGMITEQEA KHRREKVAREADFYGAMDGASKFVKGDAIAGIIIVMINIIFGIVIGMLQQGMSIQEAA SHFTMLTVGDGIVSQIPALLISTATGIVVTRAASEGNLGHDITGQLFAYPKLLYVAAA TIMLLGIFTPIGILLTGPLAGLLAFGAYTLSKSGKEKEEVDEILEEEAEVDELKSPES VVQLLHIDPIEFEFGYGLIPLADANQGGDLLDRIVMIRRQLALELGLVIPVVRIRDNI ALQPNEYRLKIKGNEVAKGELLLDHYLAMSPTPEDDLIEGIETVEPSFGLPAKWISEA VKDEADMLGYTVVDPASVVSTHITEKIKQHAHELIGRQETKQLIDHLKESYPVLVEEV TPNPLSVGDIQKVLAKLLKEKVSIRNLVTIFETLADYGKLTTDSDLLTEYTRQALAKQ ITAQFAKENEVLKVVTCSGRVEKAIADGVQQTEHGNYLSLEPDISESIVRSVAKEAEQ LSLRQETAILLCSPPVRMYVKQLLERYFPDLPVLSYNELEANVEVQSIGVVDI*" /label="flhA CDS" gene 1620042..1622075 /gene="flhA" /locus_tag="BSU_16390" /old_locus_tag="BSU16390" /label="flhA gene" CDS 1622075..1623175 /gene="flhF" /locus_tag="BSU_16400" /old_locus_tag="BSU16400" /function="16.5: Explore" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 1447978, 15317803, 16980502, 17565194, 17699634, 26195616, 27807433; Product type t: transporter" /codon_start=1 /transl_table=11 /product="GTPase involved in the export of flagella and number regulation" /protein_id="NP_389522.1" /db_xref="EnsemblGenomes-Gn:BSU16400" /db_xref="EnsemblGenomes-Tr:CAB13513" /db_xref="GOA:Q01960" /db_xref="InterPro:IPR000897" /db_xref="InterPro:IPR020006" /db_xref="InterPro:IPR027417" /db_xref="PDB:2PX0" /db_xref="PDB:2PX3" /db_xref="PDB:3SYN" /db_xref="SubtiList:BG10544" /db_xref="UniProtKB/Swiss-Prot:Q01960" /translation="MKIKKFTAASMQEAALLIRKELGNEAVILNSKKIKKRKWFGLVN KPAVEVIAVLDQDFLEKKTPQKAAEPKQTLKTPVSSPKIEERTYPPQIPAQQELGDFS AYQSVLPEPLRKAEKLLQETGIKESTKTNTLKKLLRFSVEAGGLTEENVVGKLQEILC DMLPSADKWQEPIHSKYIVLFGSTGAGKTTTLAKLAAISMLEKHKKIAFITTDTYRIA AVEQLKTYAELLQAPLEVCYTKEEFQQAKELFSEYDHVFVDTAGRNFKDPQYIDELKE TIPFESSIQSFLVLSATAKYEDMKHIVKRFSSVPVNQYIFTKIDETTSLGSVFNILAE SKIGVGFMTNGQNVPEDIQTVSPLGFVRMLCR*" /label="flhF CDS" gene 1622075..1623175 /gene="flhF" /locus_tag="BSU_16400" /old_locus_tag="BSU16400" /label="flhF gene" promotor_-10 complement(1623052..1623071) /Source="Nicolas_upshift_promotors" /id="U1326" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1367 /SigmaFactorBS="gcacattctggccgttagtcataaaCCCGACACCTatttttg attctgCCAGTATATTAAATACAGAAcctaaggaagtcgtttcatctattttcgtaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1623059) /Source="Nicolas_upshifts" /id="U1326" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1367 /SigmaFactorBS="gcacattctggccgttagtcataaaCCCGACACCTatttttg attctgCCAGTATATTAAATACAGAAcctaaggaagtcgtttcatctattttcgtaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1623085..1623094) /Source="Nicolas_upshift_promotors" /id="U1326" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1367 /SigmaFactorBS="gcacattctggccgttagtcataaaCCCGACACCTatttttg attctgCCAGTATATTAAATACAGAAcctaaggaagtcgtttcatctattttcgtaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1623166..1624062 /gene="flhG" /locus_tag="BSU_16410" /old_locus_tag="BSU16410" /function="16.5: Explore" /function="16.6: Maintain" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15361076, 25733861, 26411371" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15361076, 25733861, 26411371; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="ATPase affecting flagellar basal body localisation and number" /protein_id="NP_389523.1" /db_xref="EnsemblGenomes-Gn:BSU16410" /db_xref="EnsemblGenomes-Tr:CAB13514" /db_xref="GOA:P40742" /db_xref="InterPro:IPR025501" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR033756" /db_xref="InterPro:IPR033875" /db_xref="PDB:3SYN" /db_xref="SubtiList:BG10254" /db_xref="UniProtKB/Swiss-Prot:P40742" /translation="MQMNRYDQAATLRAKMEKRERVLPMVYSQKAKTLAVISGKGGVG KSNITLNMALALQDKGKKVLLIDLDIGMGNIDILIGNSSSATIIDVLTDRKPLLQSLS VGPKGLRYISGGTGLDVMFQLDQRKWTFFANELSHALSQFDYVLFDMGAGLSKDQLPF ILSAEDILIITTPEPTAIMDAYSAVKHLVLTENKLSMKVAVNRCRDQKEGLDAFARLS RTIHMFLDVQVQFAGSVSDDVIVSKAVVEQVPFFIKSPQAKASRSVRILADALFEREE TRHKEDKQTFIEKLSSFLMRRA*" /label="flhG CDS" gene 1623166..1624062 /gene="flhG" /locus_tag="BSU_16410" /old_locus_tag="BSU16410" /label="flhG gene" CDS 1624064..1625137 /gene="cheB" /locus_tag="BSU_16420" /old_locus_tag="BSU16420" /EC_number="3.1.1.61" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1738311, 10632876, 12123464, 21515776" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1738311, 10632876, 12123464, 21515776; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methyl-accepting chemotaxis proteins (MCP)-glutamate methylesterase" /protein_id="NP_389524.2" /db_xref="EnsemblGenomes-Gn:BSU16420" /db_xref="EnsemblGenomes-Tr:CAB13515" /db_xref="GOA:Q05522" /db_xref="InterPro:IPR000673" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR008248" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR035909" /db_xref="SubtiList:BG10255" /db_xref="UniProtKB/Swiss-Prot:Q05522" /translation="MIRVLVVDDSAFMRKMISDFLTEEKQIEVIGTARNGEEALKKIE LLKPDVITLDVEMPVMNGTDTLRKIIEIYNLPVIMVSSQTEKGKECTINCLEIGAFDF ITKPSGSISLDLYKIKEQLVERVVAAGLSGKRKRPVSQTVRPEPIVRAVVKPELSKPK PGTGRQIVCIGTSTGGPRALQKVIPKLPKDLNAPVVVVQHMPEGFTASLADRLNHLSD IQVKEAKDGEAALNGCVYIAPGGKNISVIKNSEGLQVVLDNHDTPSRHKPSADYLFRS VGKLTDYEKVAVIMTGMGSDGTAGLKDMLTAGNVKAIAESEESCVVYGMPKAAVKAGL IHEIKHVEDIAASITSCVKKERV*" /label="cheB CDS" gene 1624064..1625137 /gene="cheB" /locus_tag="BSU_16420" /old_locus_tag="BSU16420" /label="cheB gene" CDS 1625143..1627161 /gene="cheA" /locus_tag="BSU_16430" /old_locus_tag="BSU16430" /EC_number="2.7.3.-" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:12094812, 12864845, 12920116, 15451661, 16045621, 21515776, 22355139" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12094812, 12864845, 12920116, 15451661, 16045621, 21515776, 22355139; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="chemotactic two-component sensor histidine kinase" /protein_id="NP_389525.2" /db_xref="EnsemblGenomes-Gn:BSU16430" /db_xref="EnsemblGenomes-Tr:CAB13516" /db_xref="GOA:P29072" /db_xref="InterPro:IPR002545" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR004105" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR008207" /db_xref="InterPro:IPR010808" /db_xref="InterPro:IPR035891" /db_xref="InterPro:IPR036061" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036641" /db_xref="InterPro:IPR036890" /db_xref="InterPro:IPR037006" /db_xref="InterPro:IPR037052" /db_xref="SubtiList:BG10256" /db_xref="UniProtKB/Swiss-Prot:P29072" /translation="MDMNQYLDVFIDESKEHLQTCNEKLLLLEKDPTDLQLVHDIFRA AHTLKGMSATMGYTDLAHLTHLLENVLDAIRNGDMEVTSDWLDILFEALDHLETMVQS IIDGGDGKRDISEVSAKLDVNGAHAESAASAEPAEAQSSASDWEYDEFERTVIQEAEE QGFKRYEIKISLNENCMLKAVRVYMVFEKLNEVGEVAKTIPSAEVLETEDFGTDFQVC FLTHQSAEDIEQLINGVSEIEHVEVIQGAPLTSAEKPEESKQEDSPAAAVPAKQEKQK QPAKNDEQAKHSAGGSKTIRVNIDRLDSLMNLFEELVIDRGRLEQIAKELEHNELTET VERMTRISGDLQSIILNMRMVPVETVFNRFPRMIRQLQKELNKKIELSIIGAETELDR TVIDEIGDPLVHLIRNSIDHGIEAPETRLQKGKPESGKVVLKAYHSGNHVFIEVEDDG AGLNRKKILEKALERGVITEKEAETLEDNQIYELIFAPGFSTADQISDISGRGVGLDV VKNKLESLGGSVSVKSAEGQGSLFSIQLPLTLSIISVLLIKLEEETFAIPISSIIETA VIDRKDILQTHDREVIDFRGHIVPVVYLKEEFKIEDTRKDAEQLHIIVVKKGDKPTAF VVDSFIGQQEVVLKSLGDYLTNVFAISGATILGDGEVALIIDCNALII*" /label="cheA CDS" gene 1625143..1627161 /gene="cheA" /locus_tag="BSU_16430" /old_locus_tag="BSU16430" /label="cheA gene" CDS 1627183..1627653 /gene="cheW" /locus_tag="BSU_16440" /old_locus_tag="BSU16440" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:12864845, 15451661, 1624415, 8169223, 8169224" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12864845, 15451661, 1624415, 8169223, 8169224; Product type r: regulator" /codon_start=1 /transl_table=11 /product="modulation of CheA activity in response to attractants (chemotaxis)" /protein_id="NP_389526.1" /db_xref="EnsemblGenomes-Gn:BSU16440" /db_xref="EnsemblGenomes-Tr:CAB13517" /db_xref="GOA:P39802" /db_xref="InterPro:IPR002545" /db_xref="InterPro:IPR036061" /db_xref="SubtiList:BG10692" /db_xref="UniProtKB/Swiss-Prot:P39802" /translation="MTAEIKTGEKMIVFMVNGKEYAISVTQVKSIEKWQKPTRVPGVE PYICGVINLRGVVTPVIDLRKRLNLPEYEITDETRIIIIAYRDIEVGWIVDEANDVIT VHESEIESAPEGVQKDTDVSIEQIVKQENRLLNIIDANAVLDKESSQSAVPDQA*" /label="cheW CDS" gene 1627183..1627653 /gene="cheW" /locus_tag="BSU_16440" /old_locus_tag="BSU16440" /label="cheW gene" CDS 1627672..1628301 /gene="cheC" /locus_tag="BSU_16450" /old_locus_tag="BSU16450" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:12920116, 14749334, 14993307, 15546616, 16469702, 18990184, 22720735, 23226535" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12920116, 14749334, 14993307, 15546616, 16469702, 18990184, 22720735, 23226535; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="signal terminating phosphatase of CheR-mediated methylation of methyl-accepting chemotaxis proteins (MCPs)" /protein_id="NP_389527.1" /db_xref="EnsemblGenomes-Gn:BSU16450" /db_xref="EnsemblGenomes-Tr:CAB13518" /db_xref="GOA:P40403" /db_xref="InterPro:IPR007597" /db_xref="InterPro:IPR028976" /db_xref="SubtiList:BG10749" /db_xref="UniProtKB/Swiss-Prot:P40403" /translation="MSIFNGIKEEQMDILREVGNIGAGHSASAMAQLLNRKIDMEVPF AKLLSFDELVDFFGGADVPVASIFLRMEGDLTGSMFFIMPFFQAEQFIRELIGNPDFD IEDLGEDHMSSSALHELGNILAGSYLTALADLTKLQLYPSVPEVSLDMFGAVISEGLM ELSQVGEHAIVVDTSIFDQSHQQELKAHMFMLPDYDSFEKLFVALGASL*" /label="cheC CDS" gene 1627672..1628301 /gene="cheC" /locus_tag="BSU_16450" /old_locus_tag="BSU16450" /label="cheC gene" CDS 1628298..1628798 /gene="cheD" /locus_tag="BSU_16460" /old_locus_tag="BSU16460" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15546616, 16469702, 22720735, 23226535" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15546616, 16469702, 22720735, 23226535; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="sequence specific deamidase required for methylation of methyl-accepting chemotaxis proteins (MCPs) by CheR" /protein_id="NP_389528.1" /db_xref="EnsemblGenomes-Gn:BSU16460" /db_xref="EnsemblGenomes-Tr:CAB13519" /db_xref="GOA:P40404" /db_xref="InterPro:IPR005659" /db_xref="InterPro:IPR011324" /db_xref="SubtiList:BG10750" /db_xref="UniProtKB/Swiss-Prot:P40404" /translation="MSTTEAVVIKVGIADVKIARFPDTIRTSGLGSCVGLVLYDKEKQ TAGLVHVMLPDSTLSKTAELNRAKYADTAVQTTIDMLIEAGCRKFALKAKLAGGSEMF KFKSTNDLMKIGPRNVLAIKEQLSLFNIPIISEDTGGSSGRTIEFEPKSCMLHIRTVK QGEKTI*" /label="cheD CDS" gene 1628298..1628798 /gene="cheD" /locus_tag="BSU_16460" /old_locus_tag="BSU16460" /label="cheD gene" CDS 1628821..1629585 /gene="sigD" /locus_tag="BSU_16470" /old_locus_tag="BSU16470" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:2498284, 9648743, 9657996, 11751842, 15033535, 15066026, 15175317, 22329926, 22956758, 25288929, 26170408" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2498284, 9648743, 9657996, 11751842, 15033535, 15066026, 15175317, 22329926, 22956758, 25288929, 26170408; Product type r : regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase sigma-28 factor (sigma-D)" /protein_id="NP_389529.1" /db_xref="EnsemblGenomes-Gn:BSU16470" /db_xref="EnsemblGenomes-Tr:CAB13520" /db_xref="GOA:P10726" /db_xref="InterPro:IPR000943" /db_xref="InterPro:IPR007624" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR007630" /db_xref="InterPro:IPR012845" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10751" /db_xref="UniProtKB/Swiss-Prot:P10726" /translation="MQSLNYEDQVLWTRWKEWKDPKAGDDLMRRYMPLVTYHVGRISV GLPKSVHKDDLMSLGMLGLYDALEKFDPSRDLKFDTYASFRIRGAIIDGLRKEDWLPR TSREKTKKVEAAIEKLEQRYLRNVSPAEIAEELGMTVQDVVSTMNEGFFANLLSIDEK LHDQDDGENIQVMIRDDKNVPPEEKIMKDELIAQLAEKIHELSEKEQLVVSLFYKEEL TLTEIGQVLNLSTSRISQIHSKALFKLKNLLEKVIQ*" /label="sigD CDS" gene 1628821..1629585 /gene="sigD" /locus_tag="BSU_16470" /old_locus_tag="BSU16470" /label="sigD gene" promotor_-35 1629595..1629601 /Source="Nicolas_upshift_promotors" /id="U1327" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.665334665334665" /psig="0.665334665334665" /xcortree=682 /SigmaFactorBS="aaaagtgatacaataatgaatttcaTGGTTAGcgagtgaaaa acatGTCAACACTATTatggcttttaagctttatgctccacggcgttcttctgtacgc t" /listShort="ylxL" /listLong="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" CDS 1629614..1630117 /gene="swrB" /locus_tag="BSU_16480" /old_locus_tag="BSU16480" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15066026, 15175317, 19202088, 21736639, 26244495" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15066026, 15175317, 19202088, 21736639, 26244495; Product type r: regulator" /codon_start=1 /transl_table=11 /product="coupling factor for flagellin transcription and translation" /protein_id="NP_389530.1" /db_xref="EnsemblGenomes-Gn:BSU16480" /db_xref="EnsemblGenomes-Tr:CAB13521" /db_xref="SubtiList:BG10752" /db_xref="UniProtKB/Swiss-Prot:P40405" /translation="MSTLLWLLSFMLHGVLLYAVIILYTRLAAVKETEKQQKQILEET ENTLAAFLLELKEENEKLIENKASSASQSDEESQKSGLQTSETYQERDPVQEAENLPE HIEGLITEVDRREELVNSEVQSFEDQVIELYEQGYSASQIAQKMKSGKTEIELFLKFR SKGVKDS*" /label="swrB CDS" gene 1629614..1630117 /gene="swrB" /locus_tag="BSU_16480" /old_locus_tag="BSU16480" /label="swrB gene" promotor_-10 1629616..1629627 /Source="Nicolas_upshift_promotors" /id="U1327" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.665334665334665" /psig="0.665334665334665" /xcortree=682 /SigmaFactorBS="aaaagtgatacaataatgaatttcaTGGTTAGcgagtgaaaa acatGTCAACACTATTatggcttttaagctttatgctccacggcgttcttctgtacgc t" /listShort="ylxL" /listLong="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" upshifts 1629630 /Source="Nicolas_upshifts" /id="U1327" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.665334665334665" /psig="0.665334665334665" /xcortree=682 /SigmaFactorBS="aaaagtgatacaataatgaatttcaTGGTTAGcgagtgaaaa acatGTCAACACTATTatggcttttaagctttatgctccacggcgttcttctgtacgc t" /listShort="ylxL" /listLong="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591, S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" promotor_-35 1630113..1630119 /Source="Nicolas_upshift_promotors" /id="U1328" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.782217782217782" /psig=1 /xcortree=2651 /SigmaFactorBS="ctatttttaaaatttcgctccaaaggtgtaaaggattCTTGA TTgtcggataaagctgTGTTATATTATGTCTTGGTGttaaatacacacgcttaacgat t" /listShort="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1630134..1630153 /Source="Nicolas_upshift_promotors" /id="U1328" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.782217782217782" /psig=1 /xcortree=2651 /SigmaFactorBS="ctatttttaaaatttcgctccaaaggtgtaaaggattCTTGA TTgtcggataaagctgTGTTATATTATGTCTTGGTGttaaatacacacgcttaacgat t" /listShort="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" S_feature 1630136..1630260 /Source="Nicolas_S_feature" /locus_tag="new_1717808_1717932" /HighExp="GM 45, GM 15, H2O2, M9-exp, LBGexp, C30, MG 90, GM-0.1, G135, SMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="SigGF, SigD, SigA, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.665, 1, 0.994, 0.998, 1, 0.999, 1, 1, 1" /label="S586" upshifts 1630136 /Source="Nicolas_upshifts" /id="U1328" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.782217782217782" /psig=1 /xcortree=2651 /SigmaFactorBS="ctatttttaaaatttcgctccaaaggtgtaaaggattCTTGA TTgtcggataaagctgTGTTATATTATGTCTTGGTGttaaatacacacgcttaacgat t" /listShort="S586, rpsB, S587, tsf, S588, pyrH, frr, S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" CDS 1630261..1631001 /gene="rpsB" /locus_tag="BSU_16490" /old_locus_tag="BSU16490" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9090122, 10675340, 12682299; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S2" /protein_id="NP_389531.1" /db_xref="EnsemblGenomes-Gn:BSU16490" /db_xref="EnsemblGenomes-Tr:CAB13522" /db_xref="GOA:P21464" /db_xref="InterPro:IPR001865" /db_xref="InterPro:IPR005706" /db_xref="InterPro:IPR018130" /db_xref="InterPro:IPR023591" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG19004" /db_xref="UniProtKB/Swiss-Prot:P21464" /translation="MSVISMKQLLEAGVHFGHQTRRWNPKMKRYIFTERNGIYIIDLQ KTVKKVEEAYNFTKNLAAEGGKILFVGTKKQAQDSVKEEAQRSGMYYVNQRWLGGTLT NFETIQKRIKRLKDIEKMQENGTFDVLPKKEVVQLKKELERLEKFLGGIKDMKDLPDA LFIIDPRKERIAVAEARKLNIPIIGIVDTNCDPDEIDVVIPANDDAIRAVKLLTSKMA DAILEAKQGEEEAEVAEETAPETETTTA*" /label="rpsB CDS" gene 1630261..1631001 /gene="rpsB" /locus_tag="BSU_16490" /old_locus_tag="BSU16490" /label="rpsB gene" downshifts 1630983 /Source="Nicolas_upshifts" /id="D896" /incds=0 /nref=4 /ntot=61 /MaxReadThrough="9.04923" /MaxDrop="4.1312" /score="7.42766835" /energy="-14.3" /TU="U1324,U1328" /idTUdmin="U1323" /TUdmin=869 /isTUend="FALSE" /label="downshifts" S_feature 1631028..1631102 /Source="Nicolas_S_feature" /locus_tag="new_1718700_1718774" /HighExp="LPh, dia0, G150, G180, LBGexp, Lbexp, HPh, Oxctl, dia15, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="SigGF, SigD, SigA, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.665, 1, 0.994, 0.998, 1, 0.999, 1, 1, 1" /label="S587" CDS 1631103..1631984 /gene="tsf" /locus_tag="BSU_16500" /old_locus_tag="BSU16500" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 6396082, 9244380, 9973356, 27624934; Product type f: factor" /codon_start=1 /transl_table=11 /product="elongation factor Ts" /protein_id="NP_389532.1" /db_xref="EnsemblGenomes-Gn:BSU16500" /db_xref="EnsemblGenomes-Tr:CAB13523" /db_xref="GOA:P80700" /db_xref="InterPro:IPR001816" /db_xref="InterPro:IPR009060" /db_xref="InterPro:IPR014039" /db_xref="InterPro:IPR018101" /db_xref="InterPro:IPR036402" /db_xref="SubtiList:BG19025" /db_xref="UniProtKB/Swiss-Prot:P80700" /translation="MAITAQQVKELREKTGAGMMDCKKALTETDGDMDKAIDLLREKG IAKAAKKADRIAAEGSTLIKTDGNKGVILEVNSETDFVAKNEGFKELLNTLADHLLAN TPADVEEAMGQKMENGSTVEEYITSAVAKIGEKITLRRFTVLTKDDSSAFGAYLHMGG RIGVLTVLNGTTDEETAKDIAMHVAAVNPRYISRDQVSEEETNHERQILTQQALQEGK PENIVAKMVEGRLNKFFEEICLLDQAFVKNPDEKVKQVIAAKNATVQTFVRYEVGEGI EKRQENFAEEVMNQVKK*" /label="tsf CDS" gene 1631103..1631984 /gene="tsf" /locus_tag="BSU_16500" /old_locus_tag="BSU16500" /label="tsf gene" S_feature 1631985..1632129 /Source="Nicolas_S_feature" /locus_tag="new_1719657_1719801" /HighExp="LBGexp, G150, LBGtran, G135, G180, LPh, Oxctl, dia0, Lbexp, M9-exp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="SigGF, SigD, SigA, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.665, 1, 0.994, 0.998, 1, 0.999, 1, 1, 1" /label="S588" CDS 1632130..1632852 /gene="pyrH" /locus_tag="BSU_16510" /old_locus_tag="BSU16510" /EC_number="2.7.4.22" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9862121, 12682299, 12869195, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9862121, 12682299, 12869195, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="uridylate kinase" /protein_id="NP_389533.2" /db_xref="EnsemblGenomes-Gn:BSU16510" /db_xref="EnsemblGenomes-Tr:CAB13524" /db_xref="GOA:O31749" /db_xref="InterPro:IPR001048" /db_xref="InterPro:IPR011817" /db_xref="InterPro:IPR015963" /db_xref="InterPro:IPR036393" /db_xref="SubtiList:BG12675" /db_xref="UniProtKB/Swiss-Prot:O31749" /translation="MEKPKYKRIVLKLSGEALAGEQGNGINPTVIQSIAKQVKEIAEL EVEVAVVVGGGNLWRGKTGSDLGMDRATADYMGMLATVMNSLALQDSLETLGIQSRVQ TSIEMRQVAEPYIRRKAIRHLEKKRVVIFAAGTGNPYFSTDTTAALRAAEIEADVILM AKNNVDGVYNADPRKDESAVKYESLSYLDVLKDGLEVMDSTASSLCMDNDIPLIVFSI MEEGNIKRAVIGESIGTIVRGK*" /label="pyrH CDS" gene 1632130..1632852 /gene="pyrH" /locus_tag="BSU_16510" /old_locus_tag="BSU16510" /label="pyrH gene" CDS 1632854..1633411 /gene="frr" /locus_tag="BSU_16520" /old_locus_tag="BSU16520" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9862121, 12480895, 12682299, 14586115; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosome recycling factor" /protein_id="NP_389534.1" /db_xref="EnsemblGenomes-Gn:BSU16520" /db_xref="EnsemblGenomes-Tr:CAB13525" /db_xref="GOA:P81101" /db_xref="InterPro:IPR002661" /db_xref="InterPro:IPR023584" /db_xref="InterPro:IPR036191" /db_xref="SubtiList:BG12587" /db_xref="UniProtKB/Swiss-Prot:P81101" /translation="MSKEVLTQTKEKMEKAIAAYQRELATVRAGRANPSLLDKVTVEY YGAQTPLNQLSSINVPEARMLVITPYDKTAIGDIEKAILKADLGLTPTSDGNMIRIAI PALTEERRKELVKVVKKYAEEAKVAVRNVRRDANDDLKKLEKNGDITEDELRASTEDV QKLTDEYVSKIDSVTKDKEKEIMEV*" /label="frr CDS" gene 1632854..1633411 /gene="frr" /locus_tag="BSU_16520" /old_locus_tag="BSU16520" /label="frr gene" downshifts complement(1633358) /Source="Nicolas_upshifts" /id="D897" /incds=0 /nref=1 /ntot=70 /MaxReadThrough="3.38183" /MaxDrop="3.17183" /score="-5.69560888" /energy="-4.8" /TU="NA" /idTUdmin="U1326" /TUdmin="-10739" /isTUend="FALSE" /label="downshifts" promotor_-35 1633400..1633403 /Source="Nicolas_upshift_promotors" /id="U1329" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.616383616383616" /psig="0.773226773226773" /xcortree=536 /SigmaFactorBS="acaaaagacaaagaaaaagaaatcATGGaagtttaatgaaaa ACTATGTACAATAGATAATAgtgaaaagaccctctcatgtttacagggggtttttttg t" /listShort="S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1633418..1633437 /Source="Nicolas_upshift_promotors" /id="U1329" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.616383616383616" /psig="0.773226773226773" /xcortree=536 /SigmaFactorBS="acaaaagacaaagaaaaagaaatcATGGaagtttaatgaaaa ACTATGTACAATAGATAATAgtgaaaagaccctctcatgtttacagggggtttttttg t" /listShort="S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" S_feature 1633436..1633541 /Source="Nicolas_S_feature" /locus_tag="new_1721108_1721213" /HighExp="G180, G135, T3.30H, Oxctl, G150, Cold, Paraq, C30, T3.0H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.773, 1, 0.998" /TUlongSig="SigGF, SigD, SigA, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.665, 1, 0.994, 0.998, 1, 0.999, 1, 1, 1" /label="S589" upshifts 1633436 /Source="Nicolas_upshifts" /id="U1329" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.616383616383616" /psig="0.773226773226773" /xcortree=536 /SigmaFactorBS="acaaaagacaaagaaaaagaaatcATGGaagtttaatgaaaa ACTATGTACAATAGATAATAgtgaaaagaccctctcatgtttacagggggtttttttg t" /listShort="S589, uppS, cdsA, dxr, rseP, proS, S590, polC, S591" /listLong="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" CDS 1633542..1634324 /gene="uppS" /locus_tag="BSU_16530" /old_locus_tag="BSU16530" /EC_number="2.5.1.31" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15788389, 16014871, 22904278, 23840410, 27578312" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15788389, 16014871, 22904278, 23840410, 27578312; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="undecaprenyl pyrophosphate synthase" /protein_id="NP_389535.1" /db_xref="EnsemblGenomes-Gn:BSU16530" /db_xref="EnsemblGenomes-Tr:CAB13526" /db_xref="GOA:O31751" /db_xref="InterPro:IPR001441" /db_xref="InterPro:IPR018520" /db_xref="InterPro:IPR036424" /db_xref="SubtiList:BG13408" /db_xref="UniProtKB/Swiss-Prot:O31751" /translation="MLNILKNWKNQQTAASNLERYTKEDILKGEIPEHIAIIMDGNGR WAKKRSLPRIAGHHEGMKVVKRTTKLANELGVKVLTLYAFSTENWKRPKMEVDFLMKL PEEFLNTYLPELVEENVQVRIIGDETALPAHTLRAIEKAVQDTAQNDGMILNFALNYG GRTEIVSAAKSLAEKVKEGSLNIEDIDESLFSTYLMTESLQDPELLIRTSGEIRLSNF MLWQVAYSEFVFTDVLWPDFKEDHFLQALGEFQQRGRRFGGI*" /label="uppS CDS" gene 1633542..1634324 /gene="uppS" /locus_tag="BSU_16530" /old_locus_tag="BSU16530" /label="uppS gene" CDS 1634328..1635137 /gene="cdsA" /locus_tag="BSU_16540" /old_locus_tag="BSU16540" /EC_number="2.7.7.41" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 175832, 12682299, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphatidate cytidylyltransferase (CDP-diglyceride synthase)" /protein_id="NP_389536.1" /db_xref="EnsemblGenomes-Gn:BSU16540" /db_xref="EnsemblGenomes-Tr:CAB13527" /db_xref="GOA:O31752" /db_xref="InterPro:IPR000374" /db_xref="SubtiList:BG12575" /db_xref="UniProtKB/Swiss-Prot:O31752" /translation="MVDMKQRILTGVLAAIVFLFLVIVGKLPFTILIYAMGSVALFEL LRMKKLKLVSLPGLIGLLLLWMFLLPSQYSFFEADGISKMEIALFAVLLLLTYTVLVK NTFTFDEVGFITLAAIYIGMCFHYFIEIRNLDQYGLTYIFYACVVIWSTDSGAYFVGK SLGKRKLWPEISPNKTVEGFAGGIVIALVLATIFQLVAQLPIPYIYLLLITLFLSVFG QLGDLVESALKRHYDVKDSGNILPGHGGILDRFDSFLFVMPFLYFLLALFS*" /label="cdsA" gene 1634328..1635137 /gene="cdsA" /locus_tag="BSU_16540" /old_locus_tag="BSU16540" /label="cdsA gene" promotor_-35 1635118..1635125 /Source="Nicolas_upshift_promotors" /id="U1330" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.958041958041958" /psig=1 /xcortree=2056 /SigmaFactorBS="gacagtttcttgtttgtcatgcctttcttgtactttcTGCTT GCCcttttttcataaaaAAGTCTAATATGAATATGAGactgatcatgcagcaataaga a" /listShort="dxr, rseP, proS, S590, polC, S591, S592" /listLong="S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-35" promotor_-10 1635140..1635159 /Source="Nicolas_upshift_promotors" /id="U1330" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.958041958041958" /psig=1 /xcortree=2056 /SigmaFactorBS="gacagtttcttgtttgtcatgcctttcttgtactttcTGCTT GCCcttttttcataaaaAAGTCTAATATGAATATGAGactgatcatgcagcaataaga a" /listShort="dxr, rseP, proS, S590, polC, S591, S592" /listLong="S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="promotor_-10" upshifts 1635141 /Source="Nicolas_upshifts" /id="U1330" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.958041958041958" /psig=1 /xcortree=2056 /SigmaFactorBS="gacagtttcttgtttgtcatgcctttcttgtactttcTGCTT GCCcttttttcataaaaAAGTCTAATATGAATATGAGactgatcatgcagcaataaga a" /listShort="dxr, rseP, proS, S590, polC, S591, S592" /listLong="S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /label="upshifts" CDS 1635199..1636350 /gene="dxr" /locus_tag="BSU_16550" /old_locus_tag="BSU16550" /EC_number="1.1.1.267" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15567415, 17458547, 21296950, 23840410" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15567415, 17458547, 21296950, 23840410; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="1-deoxy-D-xylulose-5-phosphate reductoisomerase" /protein_id="NP_389537.2" /db_xref="EnsemblGenomes-Gn:BSU16550" /db_xref="EnsemblGenomes-Tr:CAB13528" /db_xref="GOA:O31753" /db_xref="InterPro:IPR003821" /db_xref="InterPro:IPR013512" /db_xref="InterPro:IPR013644" /db_xref="InterPro:IPR026877" /db_xref="InterPro:IPR036169" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13409" /db_xref="UniProtKB/Swiss-Prot:O31753" /translation="MKNICLLGATGSIGEQTLDVLRAHQDQFQLVSMSFGRNIDKAVP MIEVFQPKFVSVGDLDTYHKLKQMSFSFECQIGLGEEGLIEAAVMEEVDIVVNALLGS VGLIPTLKAIEQKKTIALANKETLVTAGHIVKEHAKKYDVPLLPVDSEHSAIFQALQG EQAKNIERLIITASGGSFRDKTREELESVTVEDALKHPNWSMGAKITIDSATMMNKGL EVIEAHWLFDIPYEQIDVVLHKESIIHSMVEFHDKSVIAQLGTPDMRVPIQYALTYPD RLPLPDAKRLELWEIGSLHFEKADFDRFRCLQFAFESGKIGGTMPTVLNAANEVAVAA FLAGKIPFLAIEDCIEKALTRHQLLKKPSLADIQEVDKDTRGYVNSILT*" /label="dxr CDS" gene 1635199..1636350 /gene="dxr" /locus_tag="BSU_16550" /old_locus_tag="BSU16550" /label="dxr gene" CDS 1636357..1637625 /gene="rasP" /locus_tag="BSU_16560" /old_locus_tag="BSU16560" /EC_number="3.4.24.-" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:15130127, 15496982, 15520285, 16014871, 16899079, 18599827, 19889088, 20644139, 21810987, 26735940, 28376795, 28674070" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15130127, 15496982, 15520285, 16014871, 16899079, 18599827, 19889088, 20644139, 21810987, 26735940, 28376795, 28674070; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="inner membrane zinc metalloprotease required forthe extracytoplasmic stress response mediated by sigma(W)" /protein_id="NP_389538.1" /db_xref="EnsemblGenomes-Gn:BSU16560" /db_xref="EnsemblGenomes-Tr:CAB13529" /db_xref="GOA:O31754" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR004387" /db_xref="InterPro:IPR008915" /db_xref="InterPro:IPR036034" /db_xref="SubtiList:BG13410" /db_xref="UniProtKB/Swiss-Prot:O31754" /translation="MFVNTVIAFIIIFGTLVFFHELGHLLLAQRAGILCREFAIGFGP KIFSFKKNETVYTIRLLPVGGFVRMAGEDPEMIEVKPGYTVGLLFNKEDQVEKVIINQ KEKYPDALVIEVETADLEHDMKITGYEQGKEDELSSFTVSETSFFIVDGEEVQIAPYN RQFGSKPVWQRIKAIAAGPIMNFILAYVILVMLGLIQGVPSNEPMLGQLTDNGRAAEA GLKEGDYIQSINGEKMRSWTDIVSAVKENPEKEMDVAVKRDNKTLHISVTPEAVKDEN KKTIGRFGSYAPTEKGVLSAVAYGATSTVDVTKAILTNLSKLVTGQFKLDMLSGPVGI YDMTDQVAKTGIVNLFQFAAFLSINLGIVNLLPIPALDGGRLLFLFIEAIRGKPINRE KEAFVVFIGVAFLMLLMLVVTWNDIQRLFL*" /label="rasP CDS" gene 1636357..1637625 /gene="rasP" /locus_tag="BSU_16560" /old_locus_tag="BSU16560" /label="rasP gene" CDS 1637658..1639352 /gene="proS" /locus_tag="BSU_16570" /old_locus_tag="BSU16570" /EC_number="6.1.1.15" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 16864571, 26886480; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="prolyl-tRNA synthetase" /protein_id="NP_389539.1" /db_xref="EnsemblGenomes-Gn:BSU16570" /db_xref="EnsemblGenomes-Tr:CAB13530" /db_xref="GOA:O31755" /db_xref="InterPro:IPR002314" /db_xref="InterPro:IPR002316" /db_xref="InterPro:IPR004154" /db_xref="InterPro:IPR004500" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR007214" /db_xref="InterPro:IPR023717" /db_xref="InterPro:IPR033730" /db_xref="InterPro:IPR036621" /db_xref="InterPro:IPR036754" /db_xref="SubtiList:BG12659" /db_xref="UniProtKB/Swiss-Prot:O31755" /translation="MRQSLTLIPTLREVPADAEAKSHQLLLRAGFIRQNTSGVYSYMP LAYKVIQNIQQIVREEMEKIDAVEMLMPALQQAETWQESGRWYTYGPELMRLKDRHGR EFALGATHEEVITSLVRDEVKSYKRLPLTLYQIQSKFRDEKRPRFGLLRGREFIMKDA YSFHASAESLDETYQKMYEAYSNIFARCGINVRPVIADSGAMGGKDTHEFMALSAIGE DTIAYSDESQYAANIEMAEVLHQEVPSDEEPKALEKVHTPNVKTIEELTAFLQVSAEA CIKSVLFKADDRFVLVLVRGDHEVNDIKVKNLLHAEVVELATHEEVIQQLGTEPGFVG PVGIHQDVEVYADQAVKAMVNAVAGANEGDHHYKNVNVNRDAQIKEFADLRFIKEGDP SPDGKGTIRFAEGIEVGQVFKLGTRYSEAMNATYLDENGRAQPMLMGCYGIGVSRTLS AIAEQHHDEKGLIWPKSVAPYDLHILALNMKNDGQRELAEKLYADLKAEGYEVLYDDR AERAGVKFADSDLIGLPIRITVGKRADEGIVEVKIRQTGESTEISVDELSAFISKQ*" /label="proS CDS" gene 1637658..1639352 /gene="proS" /locus_tag="BSU_16570" /old_locus_tag="BSU16570" /label="proS gene" S_feature 1639353..1639460 /Source="Nicolas_S_feature" /locus_tag="new_1727025_1727132" /HighExp="G135, G180, G150, C30, Oxctl, H2O2, Paraq, LPh, LBGexp, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="1, 0.773, 1, 0.998" /TUlongSig="SigGF, SigD, SigA, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.665, 1, 0.994, 0.998, 1, 0.999, 1, 1, 1" /label="S590" CDS 1639461..1643774 /gene="polC" /locus_tag="BSU_16580" /old_locus_tag="BSU16580" /EC_number="2.7.7.7" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:11721055, 12081953, 12217498, 20122408, 21740522, 24106089, 28575448" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11721055, 12081953, 12217498, 20122408, 21740522, 24106089, 28575448; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA polymerase III (alpha subunit)" /protein_id="NP_389540.1" /db_xref="EnsemblGenomes-Gn:BSU16580" /db_xref="EnsemblGenomes-Tr:CAB13531" /db_xref="GOA:P13267" /db_xref="InterPro:IPR003141" /db_xref="InterPro:IPR004013" /db_xref="InterPro:IPR006054" /db_xref="InterPro:IPR006308" /db_xref="InterPro:IPR011708" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR013520" /db_xref="InterPro:IPR024754" /db_xref="InterPro:IPR028112" /db_xref="InterPro:IPR029460" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG10263" /db_xref="UniProtKB/Swiss-Prot:P13267" /translation="MEQLSVNRRQFQILLQQINMTDDTFMTYFEHGEIKKLTIHKASK SWHFHFQFKSLLPFQIYDTLTTRLTQSFAHIAKVTSSIEVQDAEVSESIVQDYWSRCI EELQGISPPIISLLNQQKPKLKGNKLIVKTKTDTEAAALKNKYSSMIQAEYRQFGFPD LQLDAEIFVSEQEVQKFREQKLAEDQERAMQALIEMEKKDKESDEDQAPSGPLVIGYQ IKDNEEIRTLDSIMDEERRITVQGYVFDVETRELKSGRTLCIFKITDYTNSILIKMFA REKEDAALMKSLKKGMWVKARGSIQNDTFVRDLVMIANDVNEIKAKTREDSAPEGEKR VELHLHSPMSQMDAVTGIGKLVEQAKKWGHEAIALTDHAVVQSFPDAYSAAKKHGIKM IYGMEANLVDDGVPIAYNAAHRLLEEETYVVFDVETTGLSAVYDTIIELAAVKVKGGE IIDKFEAFANPHRPLSATIIELTGITDDMLQDAPDVVDVIRDFREWIGDDILVAHNAS FDMGFLNVAYKKLLEVEKAKNPVIDTLELGRFLYPEFKNHRLNTLCKKFDIELTQHHR AIYDTEATAYLLLKMLKDAAEKGIQYHDELNENMGQSNAYQRSRPYHATLLAVNSTGL KNLFKLVSLSHIHYFYRVPRIPRSQLEKYREGLLIGSACDRGEVFEGMMQKSPEEVED IASFYDYLEVQPPEVYRHLLELELVRDEKALKEIIANITKLGEKLNKPVVATGNVHYL NDEDKIYRKILISSQGGANPLNRHELPKVHFRTTDEMLEAFSFLGEEKAKEIVVTNTQ KVASLVDDIKPIKDDLYTPKIEGADEEIREMSYQRARSIYGEELPEIVEARIEKELKS IIGHGFAVIYLISHKLVKRSLDDGYLVGSRGSVGSSLVATLTEITEVNPLPPHYVCPE CQHSEFFNDGSVGSGFDLPDKTCPHCGTPLKKDGHDIPFETFLGFKGDKVPDIDLNFS GEYQPQAHNYTKVLFGEDNVYRAGTIGTVAEKTAYGYVKGYAGDNNLHMRGAEIDRLV QGCTGVKRTTGQHPGGIIVVPDYMDIYDFSPIQFPADATGSEWKTTHFDFHSIHDNLL KLDILGHDDPTVIRMLQDLSGIDPKTIPTDDPEVMKIFQGTESLGVTEEQIGCKTGTL GIPEFGTRFVRQMLEDTKPTTFSELVQISGLSHGTDVWLGNAQELIHNNICELSEVIG CRDDIMVYLIYQGLEPSLAFKIMEFVRKGKGLTPEWEEEMKNNNVPDWYIDSCKKIKY MFPKAHAAAYVLMAVRIAYFKVHHALLYYAAYFTVRADDFDIDTMIKGSTAIRAVMED INAKGLDASPKEKNLLTVLELALEMCERGYSFQKVDLYRSSATEFIIDGNSLIPPFNS IPGLGTNAALNIVKAREEGEFLSKEDLQKRGKVSKTILEYLDRHGCLESLPDQNQLSL F*" /label="polC CDS" gene 1639461..1643774 /gene="polC" /locus_tag="BSU_16580" /old_locus_tag="BSU16580" /label="polC gene" S_feature 1643775..1643839 /Source="Nicolas_S_feature" /locus_tag="new_1731447_1731511" /HighExp="C30, G180, G135, Oxctl, G150, H2O2, Paraq, Cold, LBGstat, Glucon" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="1, 0.773, 1, 0.998" /TUlongSig="SigGF, SigD, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.665, 1, 0.998, 1, 0.999, 1, 1, 1" /label="S591" misc_RNA 1643785..1644002 /gene="surG" /locus_tag="BSU_misc_RNA_71" /product="small RNAs controlled by sporulation" /experiment="publication(s) with functional evidences, PMID:16385044" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16385044; Product type n: RNA" /label="surG RNA" gene 1643785..1644002 /gene="surG" /locus_tag="BSU_misc_RNA_71" /label="surG gene" promotor_-35 1643811..1643817 /Source="Nicolas_upshift_promotors" /id="U1331" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=881 /SigmaFactorBS="aagcagaatttctcagaaattctgcttctaTGCATACataag cgcaaaaagTGCCATCGTAATattagagtttctgtcacttgcttaggtatgaaggtaa g" /listShort="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB" /listLong="ribC, S594, rpsO, S595, pnpA, S596, ylxY" /label="promotor_-35" promotor_-10 1643832..1643843 /Source="Nicolas_upshift_promotors" /id="U1331" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=881 /SigmaFactorBS="aagcagaatttctcagaaattctgcttctaTGCATACataag cgcaaaaagTGCCATCGTAATattagagtttctgtcacttgcttaggtatgaaggtaa g" /listShort="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB" /listLong="ribC, S594, rpsO, S595, pnpA, S596, ylxY" /label="promotor_-10" S_feature 1643841..1643908 /Source="Nicolas_S_feature" /locus_tag="new_1731513_1731580" /HighExp="S7, S5, S4, S8, S6, S3, G180, C30, T5.0H, ferm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigA" /TUshortPSig="0.998, 1" /TUlongSig="SigA, SigA, SigGF, SigA, SigD, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.773, 1, 0.665, 0.998, 1, 0.998, 1, 0.999, 1, 1, 1" /label="S592" upshifts 1643841 /Source="Nicolas_upshifts" /id="U1331" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=881 /SigmaFactorBS="aagcagaatttctcagaaattctgcttctaTGCATACataag cgcaaaaagTGCCATCGTAATattagagtttctgtcacttgcttaggtatgaaggtaa g" /listShort="S592, S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB" /listLong="ribC, S594, rpsO, S595, pnpA, S596, ylxY" /label="upshifts" promotor_-35 1643891..1643897 /Source="Nicolas_upshift_promotors" /id="U1332" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.441558441558442" /psig=1 /xcortree=2495 /SigmaFactorBS="gtttctgtcacttgcttaggtatgaaggtaagcgtatatccA TTTGCAataaaaatatggtTATGGTATAGTTTTATTGGAaatgctaacgattaccgag g" /listShort="S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY" /listLong="mlpA" /label="promotor_-35" S_feature 1643910..1644103 /Source="Nicolas_S_feature" /locus_tag="new_1731582_1731775" /HighExp="LoTm, Cold, HPh, G180, Paraq, Oxctl, T-5.40H, BMM, G150, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF" /TUshortPSig="1, 0.998" /TUlongSig="SigA, SigA, SigA, SigGF, SigA, SigD, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="1, 0.773, 1, 0.665, 0.998, 1, 0.998, 1, 0.999, 1, 1, 1" /label="S593" upshifts 1643910 /Source="Nicolas_upshifts" /id="U1332" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.441558441558442" /psig=1 /xcortree=2495 /SigmaFactorBS="gtttctgtcacttgcttaggtatgaaggtaagcgtatatccA TTTGCAataaaaatatggtTATGGTATAGTTTTATTGGAaatgctaacgattaccgag g" /listShort="S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY" /listLong="mlpA" /label="upshifts" promotor_-10 1643911..1643930 /Source="Nicolas_upshift_promotors" /id="U1332" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.441558441558442" /psig=1 /xcortree=2495 /SigmaFactorBS="gtttctgtcacttgcttaggtatgaaggtaagcgtatatccA TTTGCAataaaaatatggtTATGGTATAGTTTTATTGGAaatgctaacgattaccgag g" /listShort="S593, ylxS, nusA, ylxR, rplGA, infB, ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY" /listLong="mlpA" /label="promotor_-10" CDS 1644104..1644574 /gene="rimP" /locus_tag="BSU_16590" /old_locus_tag="BSU16590" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15257761, 16014871, 19150615, 20188109, 21529161; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosome maturation factor" /protein_id="NP_389541.1" /db_xref="EnsemblGenomes-Gn:BSU16590" /db_xref="EnsemblGenomes-Tr:CAB13532" /db_xref="GOA:P32726" /db_xref="InterPro:IPR003728" /db_xref="InterPro:IPR028989" /db_xref="InterPro:IPR028998" /db_xref="InterPro:IPR035956" /db_xref="InterPro:IPR036847" /db_xref="SubtiList:BG10264" /db_xref="UniProtKB/Swiss-Prot:P32726" /translation="MSKKVTDTVQEMAQPIVDSLQLELVDIEFVKEGQSWFLRVFIDS DDGVDIEECAKVSEALSEKLDEADPISQNYFLEVSSPGAERPLKKKADFEKSLGKNVY IKTYEPIDGVKVFEGELAEFDGQTVTVEITIKTRKKRINIPYEKIANARLAVTF*" /label="rimP CDS" gene 1644104..1644574 /gene="rimP" /locus_tag="BSU_16590" /old_locus_tag="BSU16590" /label="rimP gene" downshifts complement(1644425) /Source="Nicolas_upshifts" /id="D898" /incds=1 /nref=3 /ntot=136 /MaxReadThrough="2.08299" /MaxDrop="3.17419" /score="-8.18111474" /energy="-9.2" /TU="NA" /idTUdmin="U1333" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 1644609..1645724 /gene="nusA" /locus_tag="BSU_16600" /old_locus_tag="BSU16600" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15978071, 16707701, 16946247, 27571753, 28507243" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15978071, 16707701, 16946247, 27571753, 28507243; Product type f : factor" /codon_start=1 /transl_table=11 /product="transcription translation coupling factor involved in Rho-dependent transcription termination" /protein_id="NP_389542.1" /db_xref="EnsemblGenomes-Gn:BSU16600" /db_xref="EnsemblGenomes-Tr:CAB13533" /db_xref="GOA:P32727" /db_xref="InterPro:IPR003029" /db_xref="InterPro:IPR004087" /db_xref="InterPro:IPR009019" /db_xref="InterPro:IPR010213" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR013735" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR022967" /db_xref="InterPro:IPR025249" /db_xref="InterPro:IPR030842" /db_xref="InterPro:IPR036555" /db_xref="PDB:2MT4" /db_xref="SubtiList:BG10265" /db_xref="UniProtKB/Swiss-Prot:P32727" /translation="MSSELLDALTILEKEKGISKEIIIEAIEAALISAYKRNFNQAQN VRVDLNRETGSIRVFARKDVVDEVYDQRLEISIEEAQGIHPEYMVGDVVEIEVTPKDF GRIAAQTAKQVVTQRVREAERGVIYSEFIDREEDIMTGIVQRLDNKFIYVSLGKIEAL LPVNEQMPNESYKPHDRIKVYITKVEKTTKGPQIYVSRTHPGLLKRLFEIEVPEIYDG TVELKSVAREAGDRSKISVRTDDPDVDPVGSCVGPKGQRVQAIVNELKGEKIDIVNWS SDPVEFVANALSPSKVLDVIVNEEEKATTVIVPDYQLSLAIGKRGQNARLAAKLTGWK IDIKSETDARELGIYPRELEEDDEPLFTEPETAESDE*" /label="nusA CDS" gene 1644609..1645724 /gene="nusA" /locus_tag="BSU_16600" /old_locus_tag="BSU16600" /label="nusA gene" promotor_no_box complement(1644671..1644771) /Source="Nicolas_upshift_promotors" /id="U1333" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.775224775224775" /psig="0.171828171828172" /xcortree=61 /SigmaFactorBS="agccagtttcacggtttagatccacccgtacattttgcgctt gattaaaattccgcttataagcagaaattaacgcagcttcgattgcttcgatgataat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1644711) /Source="Nicolas_upshifts" /id="U1333" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.775224775224775" /psig="0.171828171828172" /xcortree=61 /SigmaFactorBS="agccagtttcacggtttagatccacccgtacattttgcgctt gattaaaattccgcttataagcagaaattaacgcagcttcgattgcttcgatgataat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 1645738..1646013 /gene="rulR" /locus_tag="BSU_16610" /old_locus_tag="BSU16610" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11679764, 12682299, 26771646, 27435445; Product type f: factor" /codon_start=1 /transl_table=11 /product="molecular ruler co-factor for RNA; new fold" /protein_id="NP_389543.1" /db_xref="EnsemblGenomes-Gn:BSU16610" /db_xref="EnsemblGenomes-Tr:CAB13534" /db_xref="InterPro:IPR007393" /db_xref="InterPro:IPR035931" /db_xref="SubtiList:BG10266" /db_xref="UniProtKB/Swiss-Prot:P32728" /translation="MNKHKKIPLRKCVVTGEMKPKKELIRVVRSKEGEISVDPTGKKN GRGAYLTLDKECILAAKKKNTLQNQFQSQIDDQIFDELLELAEKVKK*" /label="rulR CDS" gene 1645738..1646013 /gene="rulR" /locus_tag="BSU_16610" /old_locus_tag="BSU16610" /label="rulR gene" CDS 1646015..1646317 /gene="rulQ" /locus_tag="BSU_16620" /old_locus_tag="BSU16620" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15130481, 15361074, 22355167, 26522935, 26771646" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15130481, 15361074, 22355167, 26522935, 26771646; Product type f: factor" /codon_start=1 /transl_table=11 /product="K-turn RNA binding protein" /protein_id="NP_389544.1" /db_xref="EnsemblGenomes-Gn:BSU16620" /db_xref="EnsemblGenomes-Tr:CAB13535" /db_xref="GOA:P32729" /db_xref="InterPro:IPR004037" /db_xref="InterPro:IPR004038" /db_xref="InterPro:IPR029064" /db_xref="PDB:3V7Q" /db_xref="SubtiList:BG10267" /db_xref="UniProtKB/Swiss-Prot:P32729" /translation="MSGMEWFPLLGLANRARKVVSGEDLVIKEIRNARAKLVLLTEDA SSNTAKKVTDKCNYYKVPYKKVESRAVLGRSIGKEARVVVAVTDQGFANKLISLLD*" /label="rulQ CDS" gene 1646015..1646317 /gene="rulQ" /locus_tag="BSU_16620" /old_locus_tag="BSU16620" /label="rulQ gene" CDS 1646337..1648487 /gene="infB" /locus_tag="BSU_16630" /old_locus_tag="BSU16630" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1426242, 9588797, 12682299, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1426242, 9588797, 12682299, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="initiation factor IF-2" /protein_id="NP_389545.1" /db_xref="EnsemblGenomes-Gn:BSU16630" /db_xref="EnsemblGenomes-Tr:CAB13536" /db_xref="GOA:P17889" /db_xref="InterPro:IPR000178" /db_xref="InterPro:IPR000795" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR006847" /db_xref="InterPro:IPR009000" /db_xref="InterPro:IPR015760" /db_xref="InterPro:IPR023115" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036925" /db_xref="SubtiList:BG10268" /db_xref="UniProtKB/Swiss-Prot:P17889" /translation="MAKMRVYEYAKALNVSSKEILTALKNMDLEVNNHMAMLEEKAIK KLDAKYKKGGAAAKSQKPAETNKNKQPQGVNQQSAGNQPNKIRDGKKNDVQNNQFNKN KKNNNNKKNKRNNNNNKNQHQQKPVKPKKELPEKITFSGTLTVGALAEELGKEPSELI KKLMLLGVMATINQELDKDTIELIASEYGVETEEVIVLEETELEKYEEPDNEEDLEIR PPVVTIMGHVDHGKTTLLDSIRKTKVVEGEAGGITQHIGAYQIEENGKKITFLDTPGH AAFTTMRARGAEVTDITILVVAADDGVMPQTVEAINHAKAAEVPIIVAVNKIDKESAN PDRVMQELTEYGLVPEAWGGETIFVPLSALTGKGIDELVEMILLVSEVEELKANPNRQ AKGTVIEAELDKGRGSVATLLVQTGTLHVGDPIVVGNTFGRVRAMVNDIGRRVKTAGP STPVEITGLNDVPQAGDQFLVFKDEKTARSVGEARASKQLEEQRSDKAKLSLDDLFEQ IKQGDVKDINLIVKADVQGSAEALTAALQKIEVEGVKVKIIHTGVGAITESDIILASA SNAIVIGFNVRPDGNAKSTAEAENVDIRLHRIIYKVIDEIEAAMKGMLDPEYEEKVIG QVEVRQTFKVSKIGTIAGGYVTEGTITRDSGLRLIRDGVVIFEGEVDVLKRFKDDVKE VSQGYECGITIKKYNDIREGDILEAFVMQEIERT*" /label="infB CDS" gene 1646337..1648487 /gene="infB" /locus_tag="BSU_16630" /old_locus_tag="BSU16630" /label="infB gene" promotor_-35 1648382..1648388 /Source="Nicolas_upshift_promotors" /id="U1334" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.797202797202797" /psig="0.797202797202797" /xcortree=274 /SigmaFactorBS="aggcgaagtagatgttctgaaacgctttaaagacgatgtgaa agaAGTTTCAcaaggctatgaatgTGGTATTACAATTAAGAAAtacaatgacattcgt g" /listShort="ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1648397 /Source="Nicolas_upshifts" /id="U1334" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.797202797202797" /psig="0.797202797202797" /xcortree=274 /SigmaFactorBS="aggcgaagtagatgttctgaaacgctttaaagacgatgtgaa agaAGTTTCAcaaggctatgaatgTGGTATTACAATTAAGAAAtacaatgacattcgt g" /listShort="ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1648403..1648421 /Source="Nicolas_upshift_promotors" /id="U1334" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.797202797202797" /psig="0.797202797202797" /xcortree=274 /SigmaFactorBS="aggcgaagtagatgttctgaaacgctttaaagacgatgtgaa agaAGTTTCAcaaggctatgaatgTGGTATTACAATTAAGAAAtacaatgacattcgt g" /listShort="ylxP, rbfA, truB, ribC, S594, rpsO, S595, pnpA, S596, ylxY" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1648484..1648762 /gene="ylxP" /locus_tag="BSU_16640" /old_locus_tag="BSU16640" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="fragment of conserved protein" /db_xref="EnsemblGenomes-Gn:BSU16640" /db_xref="EnsemblGenomes-Tr:CAB13537" /db_xref="InterPro:IPR007546" /db_xref="InterPro:IPR036746" /db_xref="PSEUDO:CAB13537.1" /db_xref="SubtiList:BG10269" /db_xref="UniProtKB/Swiss-Prot:P32730" /translation="MIGFAECECIIYDAGSLKEKRAVLKRILTRVQNKFNVSISEIGY QDTWQRTSFGIAAVSSSRVQTEKELQRVLAFIDSFPEIERTITRTEWF*" /label="ylxP CDS" gene 1648484..1648762 /gene="ylxP" /locus_tag="BSU_16640" /old_locus_tag="BSU16640" /pseudo /label="ylxP gene" CDS 1648779..1649132 /gene="rbfA" /locus_tag="BSU_16650" /old_locus_tag="BSU16650" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12628255, 15185964, 17996707, 21102555, 21529161, 23293003, 23611982, 24671761, 25904134, 27382067; Product type f: factor" /codon_start=1 /transl_table=11 /product="pre-ribosomal (17S) RNA binding factor A" /protein_id="NP_389547.1" /db_xref="EnsemblGenomes-Gn:BSU16650" /db_xref="EnsemblGenomes-Tr:CAB13538" /db_xref="GOA:P32731" /db_xref="InterPro:IPR000238" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR020053" /db_xref="InterPro:IPR023799" /db_xref="SubtiList:BG10270" /db_xref="UniProtKB/Swiss-Prot:P32731" /translation="MSMRANRVGEQMKKELGDIISRKLKDPRIGFLTVTDVRVSGDLQ IAKVYISVLGDEKKREEALKGLAKAKGFIRSEIGSRIRLRKTPEIEFEFDESIDYGNR IETLIHELHSEKPSE*" /label="rbfA CDS" gene 1648779..1649132 /gene="rbfA" /locus_tag="BSU_16650" /old_locus_tag="BSU16650" /label="rbfA gene" downshifts 1649123 /Source="Nicolas_upshifts" /id="D899" /incds=0 /nref=9 /ntot=130 /MaxReadThrough="6.97196" /MaxDrop="5.80207" /score="-3.06560848" /energy="-13.8" /TU="U1331,U1332,U1334" /idTUdmin="U1331" /TUdmin="-308" /isTUend="FALSE" /label="downshifts" CDS 1649214..1650143 /gene="truB" /locus_tag="BSU_16660" /old_locus_tag="BSU16660" /EC_number="5.4.99.25" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7489483, 15987897; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA pseudouridine 55 synthase" /protein_id="NP_389548.1" /db_xref="EnsemblGenomes-Gn:BSU16660" /db_xref="EnsemblGenomes-Tr:CAB13539" /db_xref="GOA:P32732" /db_xref="InterPro:IPR002501" /db_xref="InterPro:IPR014780" /db_xref="InterPro:IPR020103" /db_xref="InterPro:IPR032819" /db_xref="SubtiList:BG10271" /db_xref="UniProtKB/Swiss-Prot:P32732" /translation="MVNGVLLLHKPVGMTSHDCVMKIRKLLKTKKVGHTGTLDPEVSG VLPICVGRATKIVEYLTEKSKTYDAEITLGFSTTTEDQTGETVETKPVNHDIDKADVE KVLNSLKGKQEQIPPMYSAVKVNGKKLYEYARAGIEVERPKRMITIEDIALTTEIKHH GETASFRFTVTCSKGTYVRTLAVMIGEKLGYPAHMSHLIRTASGDFSLDECFTFDELE AQAQSGTVEEHTVPIERALNHLPKWIISDTLAKKVENGALLETPEQFSEMTSGDRIAV FTESGTCLAIYFPHPAKKGLLKPAKVLMQKSEQ*" /label="truB CDS" gene 1649214..1650143 /gene="truB" /locus_tag="BSU_16660" /old_locus_tag="BSU16660" /label="truB gene" promotor_-35 1649928..1649935 /Source="Nicolas_upshift_promotors" /id="U1335" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1975 /SigmaFactorBS="catacagttcctattgaacgtgcgctcaatCATTTGCCgaaa tggatcataAGTGATACATTAGCTAAGAAagtagaaaatggggctttgcttgagacgc c" /listShort="ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1649949..1649968 /Source="Nicolas_upshift_promotors" /id="U1335" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1975 /SigmaFactorBS="catacagttcctattgaacgtgcgctcaatCATTTGCCgaaa tggatcataAGTGATACATTAGCTAAGAAagtagaaaatggggctttgcttgagacgc c" /listShort="ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1649958 /Source="Nicolas_upshifts" /id="U1335" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=1975 /SigmaFactorBS="catacagttcctattgaacgtgcgctcaatCATTTGCCgaaa tggatcataAGTGATACATTAGCTAAGAAagtagaaaatggggctttgcttgagacgc c" /listShort="ribC, S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /GFF_Attribute="listLong" /label="upshifts" CDS 1650162..1651112 /gene="ribC" /locus_tag="BSU_16670" /old_locus_tag="BSU16670" /EC_number="2.7.1.26" /EC_number="2.7.7.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9473052, 10206712, 12456892, 15668000, 18156273, 21866869" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9473052, 10206712, 12456892, 15668000, 18156273, 21866869; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="bifunctional riboflavin kinase FAD synthase" /protein_id="NP_389549.1" /db_xref="EnsemblGenomes-Gn:BSU16670" /db_xref="EnsemblGenomes-Tr:CAB13540" /db_xref="GOA:P54575" /db_xref="InterPro:IPR002606" /db_xref="InterPro:IPR004821" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR015864" /db_xref="InterPro:IPR015865" /db_xref="InterPro:IPR023465" /db_xref="InterPro:IPR023468" /db_xref="SubtiList:BG11495" /db_xref="UniProtKB/Swiss-Prot:P54575" /translation="MKTIHITHPHHLIKEEQAKSVMALGYFDGVHLGHQKVIGTAKQI AEEKGLTLAVMTFHPHPSHVLGRDKEPKDLITPLEDKINQIEQLGTEVLYVVKFNEVF ASLSPKQFIDQYIIGLNVQHAVAGFDFTYGKYGKGTMKTMPDDLDGKAGCTMVEKLTE QDKKISSSYIRTALQNGDVELANVLLGQPYFIKGIVIHGDKRGRTIGFPTANVGLNNS YIVPPTGVYAVKAEVNGEVYNGVCNIGYKPTFYEKRPEQPSIEVNLFDFNQEVYGAAI KIEWYKRIRSERKFNGIKELTEQIEKDKQEAIRYFSNLRK*" /label="ribC CDS" gene 1650162..1651112 /gene="ribC" /locus_tag="BSU_16670" /old_locus_tag="BSU16670" /label="ribC gene" promotor_-35 1651145..1651151 /Source="Nicolas_upshift_promotors" /id="U1336" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.769230769230769" /psig="0.999000999001" /xcortree=2654 /SigmaFactorBS="ttcagcaatttgcggaaataacttgcaacgcacgcaaatttt attctaaaataTTTGCATataggcacgattttTAGTATGATAGTTTTCGTAGtcttaa a" /listShort="S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1651152..1651268 /Source="Nicolas_S_feature" /locus_tag="new_1738824_1738940" /HighExp="SMM, GM 15, Salt, T-4.40H, GM 45, T-5.40H, GM 60, MG 45, LPhT, MG t5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigB, SigA" /TUshortPSig="0.999, 1, 0.797, 1" /TUlongSig="SigGF, SigA, SigA, SigA, SigGF, SigA, SigD, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.998, 1, 0.773, 1, 0.665, 0.998, 1, 0.998, 1, 0.999, 1, 1, 1" /label="S594" upshifts 1651152 /Source="Nicolas_upshifts" /id="U1336" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.769230769230769" /psig="0.999000999001" /xcortree=2654 /SigmaFactorBS="ttcagcaatttgcggaaataacttgcaacgcacgcaaatttt attctaaaataTTTGCATataggcacgattttTAGTATGATAGTTTTCGTAGtcttaa a" /listShort="S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1651166..1651185 /Source="Nicolas_upshift_promotors" /id="U1336" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.769230769230769" /psig="0.999000999001" /xcortree=2654 /SigmaFactorBS="ttcagcaatttgcggaaataacttgcaacgcacgcaaatttt attctaaaataTTTGCATataggcacgattttTAGTATGATAGTTTTCGTAGtcttaa a" /listShort="S594, rpsO, S595, pnpA, S596, ylxY, mlpA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1651269..1651538 /gene="rpsO" /locus_tag="BSU_16680" /old_locus_tag="BSU16680" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15627386, 8825778, 20418391, 22720735, 23611891" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15627386, 8825778, 20418391, 22720735, 23611891; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S15 (BS18)" /protein_id="NP_389550.1" /db_xref="EnsemblGenomes-Gn:BSU16680" /db_xref="EnsemblGenomes-Tr:CAB13541" /db_xref="GOA:P21473" /db_xref="InterPro:IPR000589" /db_xref="InterPro:IPR005290" /db_xref="InterPro:IPR009068" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG19010" /db_xref="UniProtKB/Swiss-Prot:P21473" /translation="MAITQERKNQLINEFKTHESDTGSPEVQIAILTDSINNLNEHLR THKKDHHSRRGLLKMVGKRRNLLTYLRNKDVTRYRELINKLGLRR*" /label="rpsO CDS" gene 1651269..1651538 /gene="rpsO" /locus_tag="BSU_16680" /old_locus_tag="BSU16680" /label="rpsO gene" downshifts 1651521 /Source="Nicolas_upshifts" /id="D900" /incds=0 /nref=30 /ntot=154 /MaxReadThrough="8.65904" /MaxDrop="5.6648" /score="29.9198852" /energy="-10.2" /TU="U1332,U1334,U1335,U1336" /idTUdmin="U1331" /TUdmin=2090 /isTUend="FALSE" /label="downshifts" S_feature 1651566..1651651 /Source="Nicolas_S_feature" /locus_tag="new_1739238_1739323" /HighExp="Cold, LoTm, Oxctl, G180, H2O2, G150, dia15, Paraq, LPh, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigB, SigA" /TUshortPSig="0.999, 1, 0.797, 1" /TUlongSig="SigGF, SigA, SigA, SigA, SigGF, SigA, SigD, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.998, 1, 0.773, 1, 0.665, 0.998, 1, 0.998, 1, 0.999, 1, 1, 1" /label="S595" promotor_-35 1651632..1651635 /Source="Nicolas_upshift_promotors" /id="U1337" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.798201798201798" /psig="0.999000999001" /xcortree=2126 /SigmaFactorBS="ataacaaatcattgaaatccttttacatactactttgacATT GatatgttcaattcatTTCGTTCATAATAGGAGTAAttgattatttcacacaacgaag a" /listShort="pnpA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1651651..1651670 /Source="Nicolas_upshift_promotors" /id="U1337" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.798201798201798" /psig="0.999000999001" /xcortree=2126 /SigmaFactorBS="ataacaaatcattgaaatccttttacatactactttgacATT GatatgttcaattcatTTCGTTCATAATAGGAGTAAttgattatttcacacaacgaag a" /listShort="pnpA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1651653 /Source="Nicolas_upshifts" /id="U1337" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.798201798201798" /psig="0.999000999001" /xcortree=2126 /SigmaFactorBS="ataacaaatcattgaaatccttttacatactactttgacATT GatatgttcaattcatTTCGTTCATAATAGGAGTAAttgattatttcacacaacgaag a" /listShort="pnpA" /GFF_Attribute="listLong" /label="upshifts" CDS 1651711..1653828 /gene="pnpA" /locus_tag="BSU_16690" /old_locus_tag="BSU16690" /EC_number="2.7.7.8" /EC_number="3.1.13.1" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8636041, 8825779, 9179491, 10572137, 15805522, 19215769, 19433509, 20659169, 21859751, 22568516, 25099370, 27708634" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8636041, 8825779, 9179491, 10572137, 15805522, 19215769, 19433509, 20659169, 21859751, 22568516, 25099370, 27708634; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="polynucleotide phosphorylase (PNPase)" /protein_id="NP_389551.1" /db_xref="EnsemblGenomes-Gn:BSU16690" /db_xref="EnsemblGenomes-Tr:CAB13542" /db_xref="GOA:P50849" /db_xref="InterPro:IPR001247" /db_xref="InterPro:IPR003029" /db_xref="InterPro:IPR004087" /db_xref="InterPro:IPR004088" /db_xref="InterPro:IPR012162" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR015847" /db_xref="InterPro:IPR015848" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR022967" /db_xref="InterPro:IPR027408" /db_xref="InterPro:IPR036345" /db_xref="InterPro:IPR036456" /db_xref="InterPro:IPR036612" /db_xref="SubtiList:BG11491" /db_xref="UniProtKB/Swiss-Prot:P50849" /translation="MGQEKHVFTIDWAGRTLTVETGQLAKQANGAVMIRYGDTAVLST ATASKEPKPLDFFPLTVNYEERLYAVGKIPGGFIKREGRPSEKAVLASRLIDRPIRPL FADGFRNEVQVISIVMSVDQNCSSEMAAMFGSSLALSVSDIPFEGPIAGVTVGRIDDQ FIINPTVDQLEKSDINLVVAGTKDAINMVEAGADEVPEEIMLEAIMFGHEEIKRLIAF QEEIVAAVGKEKSEIKLFEIDEELNEKVKALAEEDLLKAIQVHEKHAREDAINEVKNA VVAKFEDEEHDEDTIKQVKQILSKLVKNEVRRLITEEKVRPDGRGVDQIRPLSSEVGL LPRTHGSGLFTRGQTQALSVCTLGALGDVQILDGLGVEESKRFMHHYNFPQFSVGETG PMRGPGRREIGHGALGERALEPVIPSEKDFPYTVRLVSEVLESNGSTSQASICASTLA MMDAGVPIKAPVAGIAMGLVKSGEHYTVLTDIQGMEDALGDMDFKVAGTEKGVTALQM DIKIEGLSREILEEALQQAKKGRMEILNSMLATLSESRKELSRYAPKILTMTINPDKI RDVIGPSGKQINKIIEETGVKIDIEQDGTIFISSTDESGNQKAKKIIEDLVREVEVGQ LYLGKVKRIEKFGAFVEIFSGKDGLVHISELALERVGKVEDVVKIGDEILVKVTEIDK QGRVNLSRKAVLREEKEKEEQQS*" /label="pnpA CDS" gene 1651711..1653828 /gene="pnpA" /locus_tag="BSU_16690" /old_locus_tag="BSU16690" /label="pnpA gene" downshifts 1653611 /Source="Nicolas_upshifts" /id="D901" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="8.05841" /MaxDrop="3.82025" /score="-9.33432702" /energy="-7.8" /TU="U1332,U1334,U1335,U1336,U1337" /idTUdmin="U1337" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" downshifts 1653812 /Source="Nicolas_upshifts" /id="D902" /incds=0 /nref=192 /ntot=270 /MaxReadThrough="5.61214" /MaxDrop="6.82185" /score="-9.33432702" /energy="-7.8" /TU="U1332,U1334,U1335,U1336" /idTUdmin="U1337" /TUdmin=3 /isTUend="TRUE" /label="downshifts" S_feature 1653857..1653945 /Source="Nicolas_S_feature" /locus_tag="new_1741529_1741617" /HighExp="G135, G180, G150, H2O2, Oxctl, LBGexp, Paraq, LoTm, LPh, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigB, SigA" /TUshortPSig="0.999, 1, 0.797, 1" /TUlongSig="SigGF, SigA, SigA, SigA, SigGF, SigA, SigD, SigA, SigA, SigA, SigD, SigA, SigA" /TUlongPSig="0.998, 1, 0.773, 1, 0.665, 0.998, 1, 0.998, 1, 0.999, 1, 1, 1" /label="S596" CDS 1653946..1654905 /gene="ylxY" /locus_tag="BSU_16700" /old_locus_tag="BSU16700" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14679227; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sugar deacetylase" /protein_id="NP_389552.1" /db_xref="EnsemblGenomes-Gn:BSU16700" /db_xref="EnsemblGenomes-Tr:CAB13543" /db_xref="GOA:P50850" /db_xref="InterPro:IPR002509" /db_xref="InterPro:IPR010916" /db_xref="InterPro:IPR011330" /db_xref="InterPro:IPR014228" /db_xref="SubtiList:BG11492" /db_xref="UniProtKB/Swiss-Prot:P50850" /translation="MYKKFVPFAVFLFLFFVSFEMMENPHALDYIGAMKKDTVTVTAS KDPLYEELLQKAPEYEVKPQNARIDKVWKSIPGYNGLKVNIEQSYKKMKQHGKFREKD LVYSQVKPSVHLESLQPEPIYKGNPDKPMVAFLINVAWGNEYLEKMLPILQKHQVKAT FFLEGNWVRNNVQLAKKIAKDGHEIGNHSYNHPDMSKLTTGRISEQLDKTNEQIEQTI GVKPKWFAPPSGSFRKAVIDIAAEKQMGTVMWTVDTIDWQKPAPSVLQTRVLSKIHNG AMILMHPTDPTAESLEALITQIKDKGYALGTVTELMDETRLLK*" /label="ylxY CDS" gene 1653946..1654905 /gene="ylxY" /locus_tag="BSU_16700" /old_locus_tag="BSU16700" /label="ylxY gene" promotor_-10 complement(1654014..1654022) /Source="Nicolas_upshift_promotors" /id="U1338" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.645354645354645" /psig="0.645354645354645" /xcortree=686 /SigmaFactorBS="tgacgccgtgacagtcaccgtatcttttttcattGCCCCTAT ataatcaagtgcaTGCGGATTTtccatcatctcaaatgagacaaaaaaaagaaataaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1654017) /Source="Nicolas_upshifts" /id="U1338" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.645354645354645" /psig="0.645354645354645" /xcortree=686 /SigmaFactorBS="tgacgccgtgacagtcaccgtatcttttttcattGCCCCTAT ataatcaagtgcaTGCGGATTTtccatcatctcaaatgagacaaaaaaaagaaataaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1654036..1654043) /Source="Nicolas_upshift_promotors" /id="U1338" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.645354645354645" /psig="0.645354645354645" /xcortree=686 /SigmaFactorBS="tgacgccgtgacagtcaccgtatcttttttcattGCCCCTAT ataatcaagtgcaTGCGGATTTtccatcatctcaaatgagacaaaaaaaagaaataaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1654509..1654514 /Source="Nicolas_upshift_promotors" /id="U1339" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.644355644355644" /psig="0.644355644355644" /xcortree=1044 /SigmaFactorBS="agattgcaaaagacggacatgaaatcggaaatcaTTCATAca atcatccggatatGAGCAAACTGACTACAGGAagaatttccgagcagctcgacaagac t" /listShort="mlpA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1654530..1654548 /Source="Nicolas_upshift_promotors" /id="U1339" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.644355644355644" /psig="0.644355644355644" /xcortree=1044 /SigmaFactorBS="agattgcaaaagacggacatgaaatcggaaatcaTTCATAca atcatccggatatGAGCAAACTGACTACAGGAagaatttccgagcagctcgacaagac t" /listShort="mlpA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1654535 /Source="Nicolas_upshifts" /id="U1339" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.644355644355644" /psig="0.644355644355644" /xcortree=1044 /SigmaFactorBS="agattgcaaaagacggacatgaaatcggaaatcaTTCATAca atcatccggatatGAGCAAACTGACTACAGGAagaatttccgagcagctcgacaagac t" /listShort="mlpA" /GFF_Attribute="listLong" /label="upshifts" CDS 1654945..1656174 /gene="mlpA" /locus_tag="BSU_16710" /old_locus_tag="BSU16710" /EC_number="3.4.24.-" /function="16.6: Maintain" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10666719, 10974125" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10666719, 10974125; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="specific processing protease" /protein_id="NP_389553.2" /db_xref="EnsemblGenomes-Gn:BSU16710" /db_xref="EnsemblGenomes-Tr:CAB13544" /db_xref="GOA:Q04805" /db_xref="InterPro:IPR001431" /db_xref="InterPro:IPR007863" /db_xref="InterPro:IPR011249" /db_xref="InterPro:IPR011765" /db_xref="SubtiList:BG10779" /db_xref="UniProtKB/Swiss-Prot:Q04805" /translation="MIKRYTCQNGVRIVLENNPTVRSVAIGVWIGTGSRHETPEINGI SHFLEHMFFKGTSTKSAREIAESFDRIGGQVNAFTSKEYTCYYAKVLDEHANYALDVL ADMFFHSTFDENELKKEKNVVYEEIKMYEDAPDDIVHDLLSKATYGNHSLGYPILGTE ETLASFNGDSLRQYMHDYYTPDRVVISVAGNISDSFIKDVEKWFGSYEAKGKATGLEK PEFHTEKLTRKKETEQAHLCLGFKGLEVGHERIYDLIVLNNVLGGSMSSRLFQDVRED KGLAYSVYSYHSSYEDSGMLTIYGGTGANQLQQLSETIQETLATLKRDGITSKELENS KEQMKGSLMLSLESTNSKMSRNGKNELLLGKHKTLDEIINELNAVNLERVNGLARQLF TEDYALALISPSGNMPS*" /label="mlpA CDS" gene 1654945..1656174 /gene="mlpA" /locus_tag="BSU_16710" /old_locus_tag="BSU16710" /label="mlpA gene" downshifts 1656163 /Source="Nicolas_upshifts" /id="D903" /incds=0 /nref=140 /ntot=219 /MaxReadThrough="1.31218" /MaxDrop="4.84427" /score="15.1952611" /energy="-12.6" /TU="NA" /idTUdmin="U1336" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1656203..1656208 /Source="Nicolas_upshift_promotors" /id="U1340" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1150 /SigmaFactorBS="gcaatatgccgtcttaaaaaggaaagcctgccccataatgga gcaGGCATTttttaatccctttcaTCATACATAGTACAAGGGGgtgacagacatgcgg c" /listShort="ymxH" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1656218 /Source="Nicolas_upshifts" /id="U1340" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1150 /SigmaFactorBS="gcaatatgccgtcttaaaaaggaaagcctgccccataatgga gcaGGCATTttttaatccctttcaTCATACATAGTACAAGGGGgtgacagacatgcgg c" /listShort="ymxH" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1656224..1656242 /Source="Nicolas_upshift_promotors" /id="U1340" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1150 /SigmaFactorBS="gcaatatgccgtcttaaaaaggaaagcctgccccataatgga gcaGGCATTttttaatccctttcaTCATACATAGTACAAGGGGgtgacagacatgcgg c" /listShort="ymxH" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1656252..1656509 /gene="ymxH" /locus_tag="BSU_16720" /old_locus_tag="BSU16720" /experiment="publication(s) with functional evidences, PMID:23396918" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23396918; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="PRC barrel protein involved in sporulation" /protein_id="NP_389554.1" /db_xref="EnsemblGenomes-Gn:BSU16720" /db_xref="EnsemblGenomes-Tr:CAB13545" /db_xref="GOA:Q04811" /db_xref="InterPro:IPR011033" /db_xref="InterPro:IPR014238" /db_xref="InterPro:IPR027275" /db_xref="SubtiList:BG10780" /db_xref="UniProtKB/Swiss-Prot:Q04811" /translation="MRLSELSGKEIVDIKRAERLGVLGQTDLEINEQDGQITALLIPT VKWFGLRKQGHDIRVPWHHIQKIGSDMIILDVPEEMPPRQE*" /label="ymxH CDS" gene 1656252..1656509 /gene="ymxH" /locus_tag="BSU_16720" /old_locus_tag="BSU16720" /label="ymxH gene" S_feature 1656510..1656564 /Source="Nicolas_S_feature" /locus_tag="new_1744182_1744236" /HighExp="S4, S3, S5, S6, S8, S7, B36, BT, LoTm, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S597" downshifts 1656537 /Source="Nicolas_upshifts" /id="D904" /incds=0 /nref=41 /ntot=56 /MaxReadThrough="0.534319999999999" /MaxDrop="6.36032" /score="29.434739" /energy="-11.7" /TU="NA" /idTUdmin="U1340" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1656606..1656615 /Source="Nicolas_upshift_promotors" /id="U1341" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1299 /SigmaFactorBS="ccggagccgatgtttttttatatggaaaaagcgcatcttttA TATTCACCGgtatttccttttgATCATAAGATGAAGGGGAGCttaacaactagagatc c" /listShort="S598, spoVFA, spoVFB, S599, asd, S600, dapG, dapA" /listLong="rnjB" /label="promotor_-35" S_feature 1656625..1656694 /Source="Nicolas_S_feature" /locus_tag="new_1744297_1744366" /HighExp="S6, S8, S7, BT, B36, S5, G/S, Pyr, B60, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S598" upshifts 1656625 /Source="Nicolas_upshifts" /id="U1341" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1299 /SigmaFactorBS="ccggagccgatgtttttttatatggaaaaagcgcatcttttA TATTCACCGgtatttccttttgATCATAAGATGAAGGGGAGCttaacaactagagatc c" /listShort="S598, spoVFA, spoVFB, S599, asd, S600, dapG, dapA" /listLong="rnjB" /label="upshifts" promotor_-10 1656629..1656648 /Source="Nicolas_upshift_promotors" /id="U1341" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1299 /SigmaFactorBS="ccggagccgatgtttttttatatggaaaaagcgcatcttttA TATTCACCGgtatttccttttgATCATAAGATGAAGGGGAGCttaacaactagagatc c" /listShort="S598, spoVFA, spoVFB, S599, asd, S600, dapG, dapA" /listLong="rnjB" /label="promotor_-10" CDS 1656695..1657588 /gene="spoVFA" /locus_tag="BSU_16730" /old_locus_tag="BSU16730" /EC_number="1.3.1.-" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8098035, 8345520, 16707666, 25402593" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8098035, 8345520, 16707666, 25402593; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore dipicolinate synthase subunit A" /protein_id="NP_389555.1" /db_xref="EnsemblGenomes-Gn:BSU16730" /db_xref="EnsemblGenomes-Tr:CAB13546" /db_xref="GOA:Q04809" /db_xref="InterPro:IPR007698" /db_xref="InterPro:IPR014215" /db_xref="InterPro:IPR031629" /db_xref="InterPro:IPR036291" /db_xref="PDB:2RIR" /db_xref="SubtiList:BG10781" /db_xref="UniProtKB/Swiss-Prot:Q04809" /translation="MLTGLKIAVIGGDARQLEIIRKLTEQQADIYLVGFDQLDHGFTG AVKCNIDEIPFQQIDSIILPVSATTGEGVVSTVFSNEEVVLKQDHLDRTPAHCVIFSG ISNAYLENIAAQAKRKLVKLFERDDIAIYNSIPTVEGTIMLAIQHTDYTIHGSQVAVL GLGRTGMTIARTFAALGANVKVGARSSAHLARITEMGLVPFHTDELKEHVKDIDICIN TIPSMILNQTVLSSMTPKTLILDLASRPGGTDFKYAEKQGIKALLAPGLPGIVAPKTA GQILANVLSKLLAEIQAEEGK*" /label="spoVFA CDS" gene 1656695..1657588 /gene="spoVFA" /locus_tag="BSU_16730" /old_locus_tag="BSU16730" /label="spoVFA gene" CDS 1657591..1658193 /gene="spoVFB" /locus_tag="BSU_16740" /old_locus_tag="BSU16740" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8098035, 8345520, 16707666, 25402593" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8098035, 8345520, 16707666, 25402593; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore dipicolinate synthase subunit B" /protein_id="NP_389556.1" /db_xref="EnsemblGenomes-Gn:BSU16740" /db_xref="EnsemblGenomes-Tr:CAB13547" /db_xref="GOA:Q04810" /db_xref="InterPro:IPR003382" /db_xref="InterPro:IPR014214" /db_xref="InterPro:IPR036551" /db_xref="SubtiList:BG10782" /db_xref="UniProtKB/Swiss-Prot:Q04810" /translation="MSSLKGKRIGFGLTGSHCTYEAVFPQIEELVNEGAEVRPVVTFN VKSTNTRFGEGAEWVKKIEDLTGYEAIDSIVKAEPLGPKLPLDCMVIAPLTGNSMSKL ANAMTDSPVLMAAKATIRNNRPVVLGISTNDALGLNGTNLMRLMSTKNIFFIPFGQDD PFKKPNSMVAKMDLLPQTIEKALMHQQLQPILVENYQGND*" /label="spoVFB CDS" gene 1657591..1658193 /gene="spoVFB" /locus_tag="BSU_16740" /old_locus_tag="BSU16740" /label="spoVFB gene" misc_feature 1658247..1658266 /Source="Nicolas_upshift_promotors" /id="U1342" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig="0.781218781218781" /xcortree=1233 /SigmaFactorBS="tgactaaatttacagaaaatctttcccaaactaaaaaattcg gtcatcacccgcatattcTATGGTAAAATAAAACGTAAaatcatagtcaaatcaattc a" /listShort="S599, asd, S600, dapG, dapA, rnjB, tepA, ylzJ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 1658247..1658318 /Source="Nicolas_S_feature" /locus_tag="new_1745919_1745990" /HighExp="S6, S7, S8, C90, S5, BT, MG 45, MG 5, SMM, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.781, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S599" upshifts 1658247 /Source="Nicolas_upshifts" /id="U1342" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig="0.781218781218781" /xcortree=1233 /SigmaFactorBS="tgactaaatttacagaaaatctttcccaaactaaaaaattcg gtcatcacccgcatattcTATGGTAAAATAAAACGTAAaatcatagtcaaatcaattc a" /listShort="S599, asd, S600, dapG, dapA, rnjB, tepA, ylzJ" /GFF_Attribute="listLong" /label="upshifts" CDS 1658319..1659359 /gene="asd" /locus_tag="BSU_16750" /old_locus_tag="BSU16750" /EC_number="1.2.1.11" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8098035, 12682299, 25355936, 25393291" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8098035, 12682299, 25355936, 25393291; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aspartate-semialdehyde dehydrogenase" /protein_id="NP_389557.1" /db_xref="EnsemblGenomes-Gn:BSU16750" /db_xref="EnsemblGenomes-Tr:CAB13548" /db_xref="GOA:Q04797" /db_xref="InterPro:IPR000319" /db_xref="InterPro:IPR000534" /db_xref="InterPro:IPR005986" /db_xref="InterPro:IPR012080" /db_xref="InterPro:IPR012280" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10783" /db_xref="UniProtKB/Swiss-Prot:Q04797" /translation="MGRGLHVAVVGATGAVGQQMLKTLEDRNFEMDTLTLLSSKRSAG TKVTFKGQELTVQEASPESFEGVNIALFSAGGSVSQALAPEAVKRGAIVIDNTSAFRM DENTPLVVPEVNEADLHEHNGIIANPNCSTIQMVAALEPIRKAYGLNKVIVSTYQAVS GAGNEAVKELYSQTQAILNKEEIEPEIMPVKGDKKHYQIAFNAIPQIDKFQDNGYTFE EMKMINETKKIMHMPDLQVAATCVRLPIQTGHSESVYIEIDRDDATVEDIKNLLKEAP GVTLQDDPSQQLYPMPADAVGKNDVFVGRIRKDLDRANGFHLWVVSDNLLKGAAWNSV QIAESLKKLNLV*" /label="asd CDS" gene 1658319..1659359 /gene="asd" /locus_tag="BSU_16750" /old_locus_tag="BSU16750" /label="asd gene" S_feature 1659360..1659450 /Source="Nicolas_S_feature" /locus_tag="new_1747032_1747122" /HighExp="S7, S6, S8, LBGtran, GM 120, dia15, Heat, LBGstat, GM 90, MG 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.781, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S600" CDS 1659451..1660665 /gene="dapG" /locus_tag="BSU_16760" /old_locus_tag="BSU16760" /EC_number="2.7.2.4" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:1906928, 8098035" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1906928, 8098035; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aspartokinase I (alpha and beta subunits)" /protein_id="NP_389558.2" /db_xref="EnsemblGenomes-Gn:BSU16760" /db_xref="EnsemblGenomes-Tr:CAB13549" /db_xref="GOA:Q04795" /db_xref="InterPro:IPR001048" /db_xref="InterPro:IPR001341" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR005260" /db_xref="InterPro:IPR018042" /db_xref="InterPro:IPR027795" /db_xref="InterPro:IPR036393" /db_xref="SubtiList:BG10784" /db_xref="UniProtKB/Swiss-Prot:Q04795" /translation="MKIIVQKFGGTSVKDDKGRKLALGHIKEAISEGYKVVVVVSAMG RKGDPYATDSLLGLLYGDQSAISPREQDLLLSCGETISSVVFTSMLLDNGVKAAALTG AQAGFLTNDQHTNAKIIEMKPERLFSVLANHDAVVVAGFQGATEKGDTTTIGRGGSDT SAAALGAAVDAEYIDIFTDVEGVMTADPRVVENAKPLPVVTYTEICNLAYQGAKVISP RAVEIAMQAKVPIRVRSTYSNDKGTLVTSHHSSKVGSDVFERLITGIAHVKDVTQFKV PAKIGQYNVQTEVFKAMANAGISVDFFNITPSEIVYTVAGNKTETAQRILMDMGYDPM VTRNCAKVSAVGAGIMGVPGVTSKIVSALSEKEIPILQSADSHTTIWVLVHEADMVPA VNALHEVFELSK*" /label="dapG CDS" gene 1659451..1660665 /gene="dapG" /locus_tag="BSU_16760" /old_locus_tag="BSU16760" /label="dapG gene" CDS 1660696..1661568 /gene="dapA" /locus_tag="BSU_16770" /old_locus_tag="BSU16770" /EC_number="4.3.3.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8098035, 9298659" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8098035, 9298659; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="4-hydroxy-tetrahydrodipicolinate synthase" /protein_id="NP_389559.1" /db_xref="EnsemblGenomes-Gn:BSU16770" /db_xref="EnsemblGenomes-Tr:CAB13550" /db_xref="GOA:Q04796" /db_xref="InterPro:IPR002220" /db_xref="InterPro:IPR005263" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR020624" /db_xref="InterPro:IPR020625" /db_xref="SubtiList:BG10785" /db_xref="UniProtKB/Swiss-Prot:Q04796" /translation="MNFGNVSTAMITPFDNKGNVDFQKLSTLIDYLLKNGTDSLVVAG TTGESPTLSTEEKIALFEYTVKEVNGRVPVIAGTGSNNTKDSIKLTKKAEEAGVDAVM LVTPYYNKPSQEGMYQHFKAIAAETSLPVMLYNVPGRTVASLAPETTIRLAADIPNVV AIKEASGDLEAITKIIAETPEDFYVYSGDDALTLPILSVGGRGVVSVASHIAGTDMQQ MIKNYTNGQTANAALIHQKLLPIMKELFKAPNPAPVKTALQLRGLDVGSVRLPLVPLT EDERLSLSSTISEL*" /label="dapA CDS" gene 1660696..1661568 /gene="dapA" /locus_tag="BSU_16770" /old_locus_tag="BSU16770" /label="dapA gene" S_feature complement(1661039..1662223) /Source="Nicolas_S_feature" /locus_tag="new_1748711_1749895_c" /HighExp="S8, S6, S4, S5, S7, S3, LoTm, T5.0H, BT, C30" /AntisenseName="dapA" /AntisenseCor="0.13444126275526899" /AntisenseRegPval="-1.6" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S601" downshifts 1661575 /Source="Nicolas_upshifts" /id="D905" /incds=0 /nref=17 /ntot=99 /MaxReadThrough="6.0497" /MaxDrop="5.05122" /score="24.080775" /energy="-11.7" /TU="U1342" /idTUdmin="U1341" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1661668..1661671 /Source="Nicolas_upshift_promotors" /id="U1343" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.862137862137862" /psig=1 /xcortree=2241 /SigmaFactorBS="cgtttcttttacatattggttttccctaaaccttctgcttta tCTTGttttctaaatttactTTCAGTTATAATAGGAACAAgtgatgatggacgggtat g" /listShort="rnjB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1661685 /Source="Nicolas_upshifts" /id="U1343" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.862137862137862" /psig=1 /xcortree=2241 /SigmaFactorBS="cgtttcttttacatattggttttccctaaaccttctgcttta tCTTGttttctaaatttactTTCAGTTATAATAGGAACAAgtgatgatggacgggtat g" /listShort="rnjB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1661687..1661706 /Source="Nicolas_upshift_promotors" /id="U1343" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.862137862137862" /psig=1 /xcortree=2241 /SigmaFactorBS="cgtttcttttacatattggttttccctaaaccttctgcttta tCTTGttttctaaatttactTTCAGTTATAATAGGAACAAgtgatgatggacgggtat g" /listShort="rnjB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1661746..1663413 /gene="rnjB" /locus_tag="BSU_16780" /old_locus_tag="BSU16780" /EC_number="3.1.-.-" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15831787, 18713320, 20025672, 20729365, 24187087, 26296725, 28384222" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15831787, 18713320, 20025672, 20729365, 24187087, 26296725, 28384222; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dual activity 5' exo-and endoribonuclease J2" /protein_id="NP_389560.2" /db_xref="EnsemblGenomes-Gn:BSU16780" /db_xref="EnsemblGenomes-Tr:CAB13551" /db_xref="GOA:O31760" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR004613" /db_xref="InterPro:IPR011108" /db_xref="InterPro:IPR030854" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG13422" /db_xref="UniProtKB/Swiss-Prot:O31760" /translation="MKKKNTENVRIIALGGVGEIGKNLYVIEIDSDIFVVDAGLMHPE NEMLGIDVVIPDISYLIERADRVKAIFLTHGHDENIGGVFYLLNKLSVPVYGTKLTLA LLREKLKQYGHNRKTDLREIHSKSVITFESTKVSFFRTIHSIPDSVGVSFKTSLGSIV CTGDFKFDQTPALNQTCDIGEIAKIGNSGVLALLSDSANAERPGYTPSEAAVSGEISD ALYNSQNRVIIAVFASNINRIQQVIHAAAQNGRKIAVAGKNLQSVLQLARKLGYIEAD DELFISVQDVKKYPKREVAIITAGSQGEPLAALTRMANKAHKQLNIEEGDTVVIASTP IPGQELIYSKTVDLLARAGAQVIFAQKRVHVSGHGSQEELKLMINLLKPKYLIPVNGE YRMQKAHSKIAEETGMKRSDIFLIEKGDVVEFRGQNVKIGDKVPYGNILIDGLGVGDI GNIVLRDRRLLSQDGILIVVITLDKQKKHLVSGPEIITRGFVYVRESEGLIVQATELV RSIVTEATETSNVEWSTLKQAMRDALNQFLYEKTKRKPMIIPIIMEV*" /label="rnjB CDS" gene 1661746..1663413 /gene="rnjB" /locus_tag="BSU_16780" /old_locus_tag="BSU16780" /label="rnjB gene" promotor_-10 complement(1662210..1662228) /Source="Nicolas_upshift_promotors" /id="U1344" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1085 /SigmaFactorBS="tcgccaatgtcgcacgtctgattaagtgcaggtgtttgGTCA AAtttgaagtctcccgtGCATACAATAGATCCAAGTgatgttttaaagctcacaccta c" /listShort="S601" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1662227) /Source="Nicolas_upshifts" /id="U1344" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1085 /SigmaFactorBS="tcgccaatgtcgcacgtctgattaagtgcaggtgtttgGTCA AAtttgaagtctcccgtGCATACAATAGATCCAAGTgatgttttaaagctcacaccta c" /listShort="S601" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1662244..1662249) /Source="Nicolas_upshift_promotors" /id="U1344" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1085 /SigmaFactorBS="tcgccaatgtcgcacgtctgattaagtgcaggtgtttgGTCA AAtttgaagtctcccgtGCATACAATAGATCCAAGTgatgttttaaagctcacaccta c" /listShort="S601" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1663401 /Source="Nicolas_upshifts" /id="D906" /incds=0 /nref=227 /ntot=263 /MaxReadThrough="4.0072" /MaxDrop="6.75416" /score="24.080775" /energy="-11.7" /TU="U1342" /idTUdmin="U1343" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1663468..1663474 /Source="Nicolas_upshift_promotors" /id="U1345" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=917 /SigmaFactorBS="cggagctgctccggtctttattttttgtccttcaagccgGGA TTGAatgaagtatctttGTTCATAATACAaagagaaactcggaaaggatgaaagcgag a" /listShort="tepA, ylzJ, spoIIIE, S602" /listLong="ymfC" /label="promotor_-35" promotor_-10 1663488..1663499 /Source="Nicolas_upshift_promotors" /id="U1345" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=917 /SigmaFactorBS="cggagctgctccggtctttattttttgtccttcaagccgGGA TTGAatgaagtatctttGTTCATAATACAaagagaaactcggaaaggatgaaagcgag a" /listShort="tepA, ylzJ, spoIIIE, S602" /listLong="ymfC" /label="promotor_-10" upshifts 1663489 /Source="Nicolas_upshifts" /id="U1345" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=917 /SigmaFactorBS="cggagctgctccggtctttattttttgtccttcaagccgGGA TTGAatgaagtatctttGTTCATAATACAaagagaaactcggaaaggatgaaagcgag a" /listShort="tepA, ylzJ, spoIIIE, S602" /listLong="ymfC" /label="upshifts" CDS 1663529..1664266 /gene="tepA" /locus_tag="BSU_16790" /old_locus_tag="BSU16790" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10455123, 15189290, 23927687" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10455123, 15189290, 23927687; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein export-enhancing protease (spore outgrowth)" /protein_id="NP_389561.3" /db_xref="EnsemblGenomes-Gn:BSU16790" /db_xref="EnsemblGenomes-Tr:CAB13552" /db_xref="GOA:Q99171" /db_xref="InterPro:IPR023562" /db_xref="InterPro:IPR029045" /db_xref="SubtiList:BG11055" /db_xref="UniProtKB/Swiss-Prot:Q99171" /translation="MDHRMENTEEERPEKNDAKDSIMNKIQQLGETTLPQLPQDTNIH CLTIIGQIEGHVQLPPQNKTTKYEHVIPQIVAIEQNPKIEGLLIILNTVGGDVEAGLA IAEMLASLSKPTVSIVLGGGHSIGVPIAVSCDYSYIAETATMTIHPVRLTGLVIGVPQ TFEYLDKMQERVVKFVTSHSNITEEKFKELMFSKGNLTRDIGTNVVGKDAVKYGLIDH AGGVGQAINKLNELIDEARKEEGRMIQ*" /label="tepA CDS" gene 1663529..1664266 /gene="tepA" /locus_tag="BSU_16790" /old_locus_tag="BSU16790" /label="tepA gene" CDS 1664263..1664475 /gene="tepJ" /locus_tag="BSU_16799" /old_locus_tag="BSU16799" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:23927687" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23927687; Product type r: regulator" /codon_start=1 /transl_table=11 /product="modulator of TepA activity (spore outgrowth)" /protein_id="YP_003097729.1" /db_xref="EnsemblGenomes-Gn:BSU16799" /db_xref="EnsemblGenomes-Tr:CAX52620" /db_xref="InterPro:IPR025619" /db_xref="UniProtKB/Swiss-Prot:C0H413" /translation="MILYTVMPQEIVFAEQNQETSAHEQIEYKGVPLLVEMKGNEAEV IQIMSTNPMHFLHPDISPGQKLKLNV*" /label="tepJ CDS" gene 1664263..1664475 /gene="tepJ" /locus_tag="BSU_16799" /old_locus_tag="BSU16799" /label="tepJ gene" misc_feature 1664503..1664522 /Source="Nicolas_upshift_promotors" /id="U1346" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.997002997002997" /psig="0.999000999001" /xcortree=2128 /SigmaFactorBS="gctgaaattaaacgtataagaatccaacccttttttaagggc aaaaTATGCTATAATAGGGGAATCctacagaaaaaacgcagcctgtaaacggctgctt t" /listShort="spoIIIE, S602, ymfC" /listLong="ymfD" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1664517 /Source="Nicolas_upshifts" /id="U1346" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.997002997002997" /psig="0.999000999001" /xcortree=2128 /SigmaFactorBS="gctgaaattaaacgtataagaatccaacccttttttaagggc aaaaTATGCTATAATAGGGGAATCctacagaaaaaacgcagcctgtaaacggctgctt t" /listShort="spoIIIE, S602, ymfC" /listLong="ymfD" /label="upshifts" CDS 1664606..1666969 /gene="spoIIIE" /locus_tag="BSU_16800" /old_locus_tag="BSU16800" /function="16.13: Shape" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11062134, 11778051, 12618465, 16430687, 17139259, 17322320, 18160039, 24297254, 24769697, 26452092; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore DNA directional translocase (motor ATPase)" /protein_id="NP_389562.3" /db_xref="EnsemblGenomes-Gn:BSU16800" /db_xref="EnsemblGenomes-Tr:CAB13553" /db_xref="GOA:P21458" /db_xref="InterPro:IPR002543" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR018541" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10763" /db_xref="UniProtKB/Swiss-Prot:P21458" /translation="MAKKKRKSRKKQAKQLNIKYELNGLLCIAISIIAILQLGVVGQT FIYLFRFFAGEWFILCLLGLLVLGVSLFWKKKTPSLLTRRKAGLYCIIASILLLSHVQ LFKNLTHKGSIESASVVRNTWELFLMDMNGSSASPDLGGGMIGALLFAASHFLFASTG SQIMAIVMILIGMILVTGRSLQETLKKWMSPIGRFIKEQWLAFIDDMKSFKSNMQSSK KTKAPSKKQKPARKKQQMEPEPPDEEGDYETVSPLIHSEPIISSFSDRNEEEESPVIE KRAEPVSKPLQDIQPETGDQETVSAPPMTFTELENKDYEMPSLDLLADPKHTGQQADK KNIYENARKLERTFQSFGVKAKVTQVHLGPAVTKYEVYPDVGVKVSKIVNLSDDLALA LAAKDIRIEAPIPGKSAIGIEVPNAEVAMVSLKEVLESKLNDRPDAKLLIGLGRNISG EAVLAELNKMPHLLVAGATGSGKSVCVNGIITSILMRAKPHEVKMMMIDPKMVELNVY NGIPHLLAPVVTDPKKASQALKKVVNEMERRYELFSHTGTRNIEGYNDYIKRANNEEG AKQPELPYIVVIVDELADLMMVASSDVEDSITRLSQMARAAGIHLIIATQRPSVDVIT GVIKANIPSRIAFSVSSQTDSRTILDMGGAEKLLGRGDMLFLPVGANKPVRVQGAFLS DDEVEKVVDHVITQQKAQYQEEMIPEETTETHSEVTDELYDEAVELIVGMQTASVSML QRRFRIGYTRAARLIDAMEERGVVGPYEGSKPREVLLSKEKYDELSS*" /label="spoIIIE CDS" gene 1664606..1666969 /gene="spoIIIE" /locus_tag="BSU_16800" /old_locus_tag="BSU16800" /label="spoIIIE gene" S_feature 1666970..1667070 /Source="Nicolas_S_feature" /locus_tag="new_1754642_1754742" /HighExp="Cold, C30, G135, Lbstat, BC, G180, G150, S8, LoTm, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.109246" /TUshortSig="SigA, SigGF" /TUshortPSig="0.999, 0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S602" promotor_-35 1667031..1667038 /Source="Nicolas_upshift_promotors" /id="U1347" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.742257742257742" /psig="0.98901098901099" /xcortree=3004 /SigmaFactorBS="atgtaaactgatcacctttcTATTTATTttttcgacaaaaca TGATATAGTTGTCCCAATTGttcaataatttttatcgaaagtggtttacggaggggaa a" /listShort="ymfC, ymfD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1667053..1667072 /Source="Nicolas_upshift_promotors" /id="U1347" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.742257742257742" /psig="0.98901098901099" /xcortree=3004 /SigmaFactorBS="atgtaaactgatcacctttcTATTTATTttttcgacaaaaca TGATATAGTTGTCCCAATTGttcaataatttttatcgaaagtggtttacggaggggaa a" /listShort="ymfC, ymfD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1667071 /Source="Nicolas_upshifts" /id="U1347" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.742257742257742" /psig="0.98901098901099" /xcortree=3004 /SigmaFactorBS="atgtaaactgatcacctttcTATTTATTttttcgacaaaaca TGATATAGTTGTCCCAATTGttcaataatttttatcgaaagtggtttacggaggggaa a" /listShort="ymfC, ymfD" /GFF_Attribute="listLong" /label="upshifts" CDS 1667113..1667838 /gene="ymfC" /locus_tag="BSU_16810" /old_locus_tag="BSU16810" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (GntR family,possibly involved in biofilm formation)" /protein_id="NP_389563.1" /db_xref="EnsemblGenomes-Gn:BSU16810" /db_xref="EnsemblGenomes-Tr:CAB13554" /db_xref="GOA:O31761" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR011663" /db_xref="InterPro:IPR028978" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13423" /db_xref="UniProtKB/Swiss-Prot:O31761" /translation="MSTKADNRHLYLKVIERIKEDIKNGIYTEKEKLPSEFELSKKLG VSRATLREALRILEEEHVIIRRHGVGTFVHSKPLFLSGIEQLNSVTKMIEQANMTPGT IFLSSQVLMPSEDDTKRFHLAEGQELFYLERVRTADGQPIVYCIDKIPMNILPNSFSH QQESMFDLLEKNSGSVISYAVTDIEPIGYHDTISPVLECDPETALLLLKQTHYDQHDK PVLYSLNYFRADKFRFHVLRKRF*" /label="ymfC CDS" gene 1667113..1667838 /gene="ymfC" /locus_tag="BSU_16810" /old_locus_tag="BSU16810" /label="ymfC gene" downshifts 1667825 /Source="Nicolas_upshifts" /id="D907" /incds=0 /nref=135 /ntot=256 /MaxReadThrough="4.863" /MaxDrop="4.01593" /score="16.3235883" /energy="-7.2" /TU="U1346,U1347" /idTUdmin="U1346" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" promotor_-35 1667894..1667900 /Source="Nicolas_upshift_promotors" /id="U1348" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=912 /SigmaFactorBS="atgtgtctgtttttttatttgcactgattcatgtttctttgT ACATACtttcattccggttaACGCAATATATAagggatgacaagaaagtgaatgggtg a" /listShort="ymfD" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1667913 /Source="Nicolas_upshifts" /id="U1348" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=912 /SigmaFactorBS="atgtgtctgtttttttatttgcactgattcatgtttctttgT ACATACtttcattccggttaACGCAATATATAagggatgacaagaaagtgaatgggtg a" /listShort="ymfD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1667915..1667926 /Source="Nicolas_upshift_promotors" /id="U1348" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=912 /SigmaFactorBS="atgtgtctgtttttttatttgcactgattcatgtttctttgT ACATACtttcattccggttaACGCAATATATAagggatgacaagaaagtgaatgggtg a" /listShort="ymfD" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1667977..1669185 /gene="bcbE" /locus_tag="BSU_16825" /old_locus_tag="BSU16825" /function="7: Transport and binding proteins" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 18502870, 27375568" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 18502870, 27375568; Product type t: transporter" /codon_start=1 /transl_table=11 /product="bacillibactin exporter" /protein_id="NP_389564.2" /db_xref="EnsemblGenomes-Gn:BSU16825" /db_xref="EnsemblGenomes-Tr:CAB13555" /db_xref="GOA:O31762" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13424" /db_xref="UniProtKB/Swiss-Prot:O31762" /translation="MKNIIALSSVPLVMTLGNSMLIPVLPMMEKKLSVTSFQVSLIIT VYSVVAIICIPIAGYLSDRFGRKKILLPCLLIAGLGGAVAAFASTYMKNPYAMILAGR VLQGIGSAGAAPIVMPFIGDLFKGDDEKVSAGLGDIETANTSGKVLSPILGALLASWY WFVPFWFIPFFCLISFLLVLFLVAKPEEDEDAPAVSEFIKSVKKIFKQDGRWLYTVFI IGCVIMFLLFGVLFYLSDTLENKYAIDGVAKGGLLAIPLLFLSTSSFIAGKKIGKDKG RMKFCVVTGMILLTLSFIALWWNHSFYFLFVFLSFGGIGIGMALPALDALITEGIESE QCGTISSFYNSMRFIGVALGPPVFAALMSNANWIIFILSAFCSIVSLFLVLFTVDAKK SEEEKNLGTV*" /label="bcbE CDS" gene 1667977..1669185 /gene="bcbE" /locus_tag="BSU_16825" /old_locus_tag="BSU16825" /label="bcbE gene" downshifts 1669143 /Source="Nicolas_upshifts" /id="D908" /incds=0 /nref=1 /ntot=32 /MaxReadThrough="1.34389" /MaxDrop="3.00655" /score="5.64651968" /energy="-6.7" /TU="NA" /idTUdmin="U1348" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1669254..1669261 /Source="Nicolas_upshift_promotors" /id="U1349" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5994005994006" /psig="0.987012987012987" /xcortree=1918 /SigmaFactorBS="cagcatgcggaggttattGTTTCCTTataaatcctacaGTTG CTATAATTACATGAAAgagtgtttctgcggatgctgaaaattggtcataatacatact a" /listShort="ymfF, ymfH, S603, ymfI, ymfJ, ymfK, ymfK, ymfM" /listLong="pgsA, cinA, S604, recA, S605, pbpX, S606, S607, ymdA, ymdB, S608, spoVS" /label="promotor_-35" promotor_-10 1669274..1669293 /Source="Nicolas_upshift_promotors" /id="U1349" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5994005994006" /psig="0.987012987012987" /xcortree=1918 /SigmaFactorBS="cagcatgcggaggttattGTTTCCTTataaatcctacaGTTG CTATAATTACATGAAAgagtgtttctgcggatgctgaaaattggtcataatacatact a" /listShort="ymfF, ymfH, S603, ymfI, ymfJ, ymfK, ymfK, ymfM" /listLong="pgsA, cinA, S604, recA, S605, pbpX, S606, S607, ymdA, ymdB, S608, spoVS" /label="promotor_-10" upshifts 1669296 /Source="Nicolas_upshifts" /id="U1349" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5994005994006" /psig="0.987012987012987" /xcortree=1918 /SigmaFactorBS="cagcatgcggaggttattGTTTCCTTataaatcctacaGTTG CTATAATTACATGAAAgagtgtttctgcggatgctgaaaattggtcataatacatact a" /listShort="ymfF, ymfH, S603, ymfI, ymfJ, ymfK, ymfK, ymfM" /listLong="pgsA, cinA, S604, recA, S605, pbpX, S606, S607, ymdA, ymdB, S608, spoVS" /label="upshifts" promotor_-35 1669308..1669311 /Source="Nicolas_upshift_promotors" /id="U1350" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.430569430569431" /psig="0.430569430569431" /xcortree=811 /SigmaFactorBS="taattacatgaaagagtgtttctgcggATGCtgaaaattggt cataATACATACTAATTaagaaatgaacgaaggaggttccatatgtcatatgttaatg a" /listShort="ymfF, ymfH, S603, ymfI, ymfJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1669327..1669339 /Source="Nicolas_upshift_promotors" /id="U1350" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.430569430569431" /psig="0.430569430569431" /xcortree=811 /SigmaFactorBS="taattacatgaaagagtgtttctgcggATGCtgaaaattggt cataATACATACTAATTaagaaatgaacgaaggaggttccatatgtcatatgttaatg a" /listShort="ymfF, ymfH, S603, ymfI, ymfJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1669341 /Source="Nicolas_upshifts" /id="U1350" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.430569430569431" /psig="0.430569430569431" /xcortree=811 /SigmaFactorBS="taattacatgaaagagtgtttctgcggATGCtgaaaattggt cataATACATACTAATTaagaaatgaacgaaggaggttccatatgtcatatgttaatg a" /listShort="ymfF, ymfH, S603, ymfI, ymfJ" /GFF_Attribute="listLong" /label="upshifts" CDS 1669365..1670645 /gene="ymfF" /locus_tag="BSU_16845" /old_locus_tag="BSU16845" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22333191; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metalloprotease" /protein_id="NP_389566.2" /db_xref="EnsemblGenomes-Gn:BSU16845" /db_xref="EnsemblGenomes-Tr:CAB13557" /db_xref="GOA:O31764" /db_xref="InterPro:IPR007863" /db_xref="InterPro:IPR011249" /db_xref="SubtiList:BG13426" /db_xref="UniProtKB/Swiss-Prot:O31764" /translation="MSYVNELKSKHGGLTAHIVKTEKFKTVSLIFKMLAPLTKDQVTK RALLPHVLLRGTKSHPKTAGLRSYLDELYGTSVSADLTKKGERHVITFRLEIPNEKYL KDQTPLLEKGLQLLAELVFSPALEGDAFQSQYVAQEKRTLKQRIQAVYDDKMRYSNLR LIQEMCKNDPYALHVNGEIDDVDDITAEQLYETYQSAIQKDQLDLYVVGDVDSNQVQS AIDKYFKTEERTLGMIENNHADEKVQPKEVIDEEDVKQGKLNIGYRTSITYTDQDYPA LQVFNGLFGGFSHSKLFINVREKASLAYYAASRIESFKGLLMVMSGIEVKNFEQAVSI IAEQFQAMKNGDFSEQDIAQTKAVIRNQVLETIDTAYGLSEFLYQQAAAQVEIPIEDF LANIENVTKEDIIKAGEKIQLDTTYFLKGTEGAS*" /label="ymfF CDS" gene 1669365..1670645 /gene="ymfF" /locus_tag="BSU_16845" /old_locus_tag="BSU16845" /label="ymfF gene" CDS 1670642..1671928 /gene="ymfH" /locus_tag="BSU_16860" /old_locus_tag="BSU16860" /EC_number="3.4.24.-" /function="16.6: Maintain" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22333191, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative processing protease" /protein_id="NP_389568.2" /db_xref="EnsemblGenomes-Gn:BSU16860" /db_xref="EnsemblGenomes-Tr:CAB13559" /db_xref="GOA:O31766" /db_xref="InterPro:IPR007863" /db_xref="InterPro:IPR011249" /db_xref="InterPro:IPR011765" /db_xref="SubtiList:BG13428" /db_xref="UniProtKB/Swiss-Prot:O31766" /translation="MIKPIEYEQLQETLYHEKMSNGLDVYVLPKKGFNKTYAVFTTKY GSIDNRFVPLGKNEMVHVPDGIAHFLEHKLFEKADGDVFQDFSKQGASANAFTSFTRT AYLFSSTSNVERNLETLIDFVQDPYFTEKTVEKEKGIIGQEINMYDDNPDWRLYFGVI ENMYKEHPVRIDIAGTVESISHITKDLLYECYETFYHPSNMLLFIVGPVDPEAIISQV RENQGKKPYTDQPEIKREEVKEQEAVFRKEKEIKMNVQGPKCLVGLKSKNPFKLGKEL LKHELSMNLLLEALFGKSSAQYESLYEKGYIDETFSFDFTAEYGFGFAAIGGDTPEPD QLAEDISSMLLRAGELITAEKIELARKKKIGTFLKALNSPEYIANQFTRYAFLDMSLF DVVTVLEQITLEDVQNVIQEEIAADRLTVCKVVPKS*" /label="ymfH CDS" gene 1670642..1671928 /gene="ymfH" /locus_tag="BSU_16860" /old_locus_tag="BSU16860" /label="ymfH gene" downshifts 1671778 /Source="Nicolas_upshifts" /id="D909" /incds=1 /nref=10 /ntot=159 /MaxReadThrough="5.673" /MaxDrop="3.16735" /score="1.51160893" /energy="-10.4" /TU="U1349,U1350" /idTUdmin="U1350" /TUdmin="-1256" /isTUend="FALSE" /label="downshifts" S_feature 1671929..1671982 /Source="Nicolas_S_feature" /locus_tag="new_1759601_1759654" /HighExp="Etha, dia15, H2O2, G135, G150, G180, Paraq, LBGexp, Oxctl, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.431, 0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S603" CDS 1671983..1672711 /gene="efpI" /locus_tag="BSU_16870" /old_locus_tag="BSU16870" /EC_number="1.1.1.-" /function="16.2: Construct biomass (Anabolism)" /function="16.5: Explore" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:15066026, 28787546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15066026, 28787546; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="EF-P-5 aminopentanone reductase (EF-P repair enzyme), NADPH-dependent" /protein_id="NP_389569.2" /db_xref="EnsemblGenomes-Gn:BSU16870" /db_xref="EnsemblGenomes-Tr:CAB13560" /db_xref="GOA:O31767" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13429" /db_xref="UniProtKB/Swiss-Prot:O31767" /translation="MNKTALITGASGGIGKSISETLAARGYNLLLHYNTNQNAAAELA EKLSQMFGVNAEILQADLSAQDGADKLTSSIVQPIDAIVLNSGRSHFGLITDVDNATV QEMVQLHVASPYMLTRNLLPGMIRNKSGAIVAVSSIWGETGASCEVLYSMAKGAQHSF VKGLAKELAPSGIRVNAVAPGAVDTNMMNQFTPAEKEEIADEIPIGRLARPQEIADAT AFLLSEKASYITGQILSVNGGWHC*" /label="efpI CDS" gene 1671983..1672711 /gene="efpI" /locus_tag="BSU_16870" /old_locus_tag="BSU16870" /label="efpI gene" promotor_-35 1672727..1672733 /Source="Nicolas_upshift_promotors" /id="U1351" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=829 /SigmaFactorBS="tcggtgaatggcggctggcactgctgatccgaaaatattcgg TGTATAGtttcttttgcgaaGGACACAATAATcttgtaacttcacatgaaatggagga a" /listShort="ymfJ, ymfK, ymfK, ymfM" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1672745 /Source="Nicolas_upshifts" /id="U1351" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=829 /SigmaFactorBS="tcggtgaatggcggctggcactgctgatccgaaaatattcgg TGTATAGtttcttttgcgaaGGACACAATAATcttgtaacttcacatgaaatggagga a" /listShort="ymfJ, ymfK, ymfK, ymfM" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1672747..1672758 /Source="Nicolas_upshift_promotors" /id="U1351" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=829 /SigmaFactorBS="tcggtgaatggcggctggcactgctgatccgaaaatattcgg TGTATAGtttcttttgcgaaGGACACAATAATcttgtaacttcacatgaaatggagga a" /listShort="ymfJ, ymfK, ymfK, ymfM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1672758) /Source="Nicolas_upshifts" /id="U1352" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.945054945054945" /psig="0.050949050949051" /xcortree=702 /SigmaFactorBS="gctatcccagttttctaatactGACATgcttgtttCCTCCAT TTCATGTGaagttacaagattattgtgtccttcgcaaaagaaactatacaccgaatat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1672769..1672783) /Source="Nicolas_upshift_promotors" /id="U1352" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.945054945054945" /psig="0.050949050949051" /xcortree=702 /SigmaFactorBS="gctatcccagttttctaatactGACATgcttgtttCCTCCAT TTCATGTGaagttacaagattattgtgtccttcgcaaaagaaactatacaccgaatat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1672792..1672796) /Source="Nicolas_upshift_promotors" /id="U1352" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.945054945054945" /psig="0.050949050949051" /xcortree=702 /SigmaFactorBS="gctatcccagttttctaatactGACATgcttgtttCCTCCAT TTCATGTGaagttacaagattattgtgtccttcgcaaaagaaactatacaccgaatat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1672792..1673049 /gene="ymfJ" /locus_tag="BSU_16880" /old_locus_tag="BSU16880" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17322312; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_389570.1" /db_xref="EnsemblGenomes-Gn:BSU16880" /db_xref="EnsemblGenomes-Tr:CAB13561" /db_xref="InterPro:IPR021637" /db_xref="InterPro:IPR024702" /db_xref="SubtiList:BG13430" /db_xref="UniProtKB/Swiss-Prot:O31768" /translation="MSVLENWDSWKNFLGDRLNYAQDKGMSQDTITDLATEIGSYLAN EVESKNEQEKVLADLWSVASKDEQHAIANMMVKLVENNSTH*" /label="ymfJ CDS" gene 1672792..1673049 /gene="ymfJ" /locus_tag="BSU_16880" /old_locus_tag="BSU16880" /label="ymfJ gene" downshifts 1673034 /Source="Nicolas_upshifts" /id="D910" /incds=0 /nref=165 /ntot=250 /MaxReadThrough="4.58488" /MaxDrop="7.23574" /score="21.9507801" /energy="-8.7" /TU="U1349,U1351" /idTUdmin="U1350" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1673066) /Source="Nicolas_upshifts" /id="D911" /incds=0 /nref=2 /ntot=15 /MaxReadThrough="3.44398" /MaxDrop="3.96475" /score="-6.33040789" /energy="-7.2" /TU="NA" /idTUdmin="U1344" /TUdmin="-11987" /isTUend="FALSE" /label="downshifts" promotor_-35 1673107..1673110 /Source="Nicolas_upshift_promotors" /id="U1353" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.883116883116883" /psig="0.998001998001998" /xcortree=2284 /SigmaFactorBS="ttcctctcttttttatgttttcctcatcacagcaacattctt CTTTctaattagagaaaaATGCTTTATGATAAAGGAAGgtaaaattttgccacaatga a" /listShort="ymfK, ymfK, ymfM, pgsA, cinA, S604, recA" /listLong="S605, pbpX, S606, S607, ymdA, ymdB, S608, spoVS" /label="promotor_-35" promotor_-10 1673125..1673144 /Source="Nicolas_upshift_promotors" /id="U1353" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.883116883116883" /psig="0.998001998001998" /xcortree=2284 /SigmaFactorBS="ttcctctcttttttatgttttcctcatcacagcaacattctt CTTTctaattagagaaaaATGCTTTATGATAAAGGAAGgtaaaattttgccacaatga a" /listShort="ymfK, ymfK, ymfM, pgsA, cinA, S604, recA" /listLong="S605, pbpX, S606, S607, ymdA, ymdB, S608, spoVS" /label="promotor_-10" upshifts 1673125 /Source="Nicolas_upshifts" /id="U1353" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.883116883116883" /psig="0.998001998001998" /xcortree=2284 /SigmaFactorBS="ttcctctcttttttatgttttcctcatcacagcaacattctt CTTTctaattagagaaaaATGCTTTATGATAAAGGAAGgtaaaattttgccacaatga a" /listShort="ymfK, ymfK, ymfM, pgsA, cinA, S604, recA" /listLong="S605, pbpX, S606, S607, ymdA, ymdB, S608, spoVS" /label="upshifts" CDS 1673179..1673694 /gene="ymfKn" /locus_tag="BSU_16890" /old_locus_tag="BSU16890" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved hypothetical protein with ACT domain; N-terminal part of YmfK" /db_xref="SubtiList:BG13431" /translation="MAKLEWYFEYEIQVNRPGLLGDISSLLGMLSINIVTINGVDLSR RGMLLRCRHIDQIKRLESILKTMETIKVTKLREPRLRDRLAVRHGRYIQRDADDKKTF RFERDELGLLVDFMAELFKKEGHKLIGIRGMPRVGKTESIVASSVCEQKVAVCVINLA EADDKKPADCR*" /label="ymfKn CDS" gene 1673179..1673694 /gene="ymfKn" /locus_tag="BSU_16890" /old_locus_tag="BSU16890" /pseudo /label="ymfKn gene" CDS 1673630..1673968 /gene="ymfKc" /locus_tag="BSU_16900" /old_locus_tag="BSU16900" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved hypothetical protein with ACT domain; C-terminal part of YmfK" /db_xref="SubtiList:BG13432" /translation="RWLFVSSTLLKQTIRSQLIADEYSTENVFIVDGIVSTRRGSERH LQLVREIMRLPATKVVEHPDIFVQNTEYTLDDFDYIIELRNDPDEVITYEHAEEPQMF DQSGFSSFDF*" /label="ymfKc CDS" gene 1673630..1673968 /gene="ymfKc" /locus_tag="BSU_16900" /old_locus_tag="BSU16900" /pseudo /label="ymfKc gene" CDS 1674035..1674901 /gene="rodZ" /locus_tag="BSU_16910" /old_locus_tag="BSU16910" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 19164570, 22720735, 23879732, 27415800, 27818647" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 19164570, 22720735, 23879732, 27415800, 27818647; Product type f : factor" /codon_start=1 /transl_table=11 /product="cell shape determination factor" /protein_id="NP_389573.3" /db_xref="EnsemblGenomes-Gn:BSU16910" /db_xref="EnsemblGenomes-Tr:CAB13564" /db_xref="GOA:O31771" /db_xref="InterPro:IPR025194" /db_xref="SubtiList:BG13433" /db_xref="UniProtKB/Swiss-Prot:O31771" /translation="MSLDDLQAATKIQKRYLTALEEGNYDIIPGKFYVRAFIKQYAEA VGLDADQLFEEHKKDIPNTYHDDVSEKISGMNLQKEMPKPASKALELLPTILVILGVI VVIAIVYAIIQFANHKNSDDHNAASEKAITQSESKYEIPKDSTLKENQNNSSEKETDT KKETKENEDKKKENDSEKLEIKAAGTEGSLTTYEVSGADKIELELKASDSSWIRVRDE NSSSLKEGTLKKDETYKKDITDQKQVDIRTGYAPNLKIKINGKVLSYELDPKKVMAQT IKIVNKKEEKSS*" /label="rodZ CDS" gene 1674035..1674901 /gene="rodZ" /locus_tag="BSU_16910" /old_locus_tag="BSU16910" /label="rodZ gene" promotor_no_box 1674098..1674198 /Source="Nicolas_upshift_promotors" /id="U1354" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.52947052947053" /psig="0.015984015984016" /xcortree=1494 /SigmaFactorBS="gaaggaaactatgacattattccggggaagttttatgttcgg gcattcatcaagcaatatgcagaagccgttgggcttgatgcggatcagctgtttgagg a" /listShort="pgsA, cinA, S604" /listLong="recA, S605, pbpX, S606, S607, ymdA, ymdB, S608, spoVS" /label="promotor_no_box" upshifts 1674158 /Source="Nicolas_upshifts" /id="U1354" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.52947052947053" /psig="0.015984015984016" /xcortree=1494 /SigmaFactorBS="gaaggaaactatgacattattccggggaagttttatgttcgg gcattcatcaagcaatatgcagaagccgttgggcttgatgcggatcagctgtttgagg a" /listShort="pgsA, cinA, S604" /listLong="recA, S605, pbpX, S606, S607, ymdA, ymdB, S608, spoVS" /label="upshifts" downshifts 1674861 /Source="Nicolas_upshifts" /id="D912" /incds=0 /nref=1 /ntot=107 /MaxReadThrough="5.43253" /MaxDrop="2.8328" /score="21.9507801" /energy="-8.7" /TU="U1353,U1354" /idTUdmin="U1351" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 1674951..1675532 /gene="pgsA" /locus_tag="BSU_16920" /old_locus_tag="BSU16920" /EC_number="2.7.8.5" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 15743965, 15849754, 16514141, 16850406, 27818647" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15743965, 15849754, 16514141, 16850406, 27818647; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase" /protein_id="NP_389574.2" /db_xref="EnsemblGenomes-Gn:BSU16920" /db_xref="EnsemblGenomes-Tr:CAB13565" /db_xref="GOA:P46322" /db_xref="InterPro:IPR000462" /db_xref="InterPro:IPR004570" /db_xref="SubtiList:BG11373" /db_xref="UniProtKB/Swiss-Prot:P46322" /translation="MFNLPNKITLARIALIPIFMIIMLAPFDWGRLEVGDESIPVAHL AGAILFIIASTTDWVDGYYARKLNLVTNFGKFLDPLADKLLVSAALIILVQFDLAPAW MVIVIISREFAVTGLRLVLAGTGEVVAANMLGKIKTWAQIIAVSALLLHNLPFELVSF PFADLALWVAVFFTVVSGWEYFSKNWEALKTSN*" /label="pgsA CDS" gene 1674951..1675532 /gene="pgsA" /locus_tag="BSU_16920" /old_locus_tag="BSU16920" /label="pgsA gene" CDS 1675550..1676800 /gene="cinA" /locus_tag="BSU_16930" /old_locus_tag="BSU16930" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10438773, 11703670, 20480359; Product type r: regulator" /codon_start=1 /transl_table=11 /product="competence-damage inducible regulator" /protein_id="NP_389575.2" /db_xref="EnsemblGenomes-Gn:BSU16930" /db_xref="EnsemblGenomes-Tr:CAB13566" /db_xref="InterPro:IPR001453" /db_xref="InterPro:IPR008135" /db_xref="InterPro:IPR008136" /db_xref="InterPro:IPR036425" /db_xref="InterPro:IPR036653" /db_xref="SubtiList:BG11374" /db_xref="UniProtKB/Swiss-Prot:P46323" /translation="MEFPKKAEIIAVGSELLLGQIANTNAQFISKQLAEIGVNVFYHT AVGDNPERLKQVIRIAEERSDFIIFSGGLGPTKDDLTKETIANTLGRPLVLNDEAFQS IEDYFKRTKRTMSPNNRKQALVIEGSDVLANHFGMAPGMLTEHESRYYMLLPGPPSEL RPMFENEAKPLLLKKMGSNEKIVSTVLRFFGIGESQLEADLEDIIDAQTNPTIAPLAA DGEVTLRLTAKHADEKETERLLKETEAVILERVGEFFYGYDDTSLVKELSIACKEKGI TISAAESFTGGLFSEWLTDHSGASKLFAGGVVCYTNDVKQNVLGVKKETLDRFGAVSK ECASELAKGVQKLTGSDIGISFTGVAGPDAQEGHEPGHVFIGISANGKEEVHEFHFAG SRTGIRKRGAKYGCHLILKLLEQK*" /label="cinA CDS" gene 1675550..1676800 /gene="cinA" /locus_tag="BSU_16930" /old_locus_tag="BSU16930" /label="cinA gene" S_feature 1676801..1676927 /Source="Nicolas_S_feature" /locus_tag="new_1764473_1764599" /HighExp="LBGstat, LBGtran, G135, Lbstat, G150, C30, LBGexp, dia0, S0, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.016, 0.998" /TUlongSig="SigA" /TUlongPSig="0.987" /label="S604" promotor_-35 1676907..1676914 /Source="Nicolas_upshift_promotors" /id="U1355" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.863136863136863" /psig=1 /xcortree=1499 /SigmaFactorBS="tcacgccaagaaaaaatccgaatatgcgttcgctttttTCTT GGCAaatcccttcaaacaGGGTATAGTATATGTAGTGGtaacataaaggaggaaaaaa t" /listShort="recA, S605, pbpX" /listLong="S606, S607, ymdA, ymdB, S608, spoVS" /label="promotor_-35" promotor_-10 1676929..1676948 /Source="Nicolas_upshift_promotors" /id="U1355" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.863136863136863" /psig=1 /xcortree=1499 /SigmaFactorBS="tcacgccaagaaaaaatccgaatatgcgttcgctttttTCTT GGCAaatcccttcaaacaGGGTATAGTATATGTAGTGGtaacataaaggaggaaaaaa t" /listShort="recA, S605, pbpX" /listLong="S606, S607, ymdA, ymdB, S608, spoVS" /label="promotor_-10" upshifts 1676929 /Source="Nicolas_upshifts" /id="U1355" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.863136863136863" /psig=1 /xcortree=1499 /SigmaFactorBS="tcacgccaagaaaaaatccgaatatgcgttcgctttttTCTT GGCAaatcccttcaaacaGGGTATAGTATATGTAGTGGtaacataaaggaggaaaaaa t" /listShort="recA, S605, pbpX" /listLong="S606, S607, ymdA, ymdB, S608, spoVS" /label="upshifts" CDS 1676973..1678019 /gene="recA" /locus_tag="BSU_16940" /old_locus_tag="BSU16940" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11555642, 16024744, 16061691, 16267290, 17229847, 22720735, 25939832, 26001966, 26930481, 28344191" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11555642, 16024744, 16061691, 16267290, 17229847, 22720735, 25939832, 26001966, 26930481, 28344191; Product type f: factor" /codon_start=1 /transl_table=11 /product="multifunctional SOS repair factor" /protein_id="NP_389576.2" /db_xref="EnsemblGenomes-Gn:BSU16940" /db_xref="EnsemblGenomes-Tr:CAB13567" /db_xref="GOA:P16971" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR013765" /db_xref="InterPro:IPR020584" /db_xref="InterPro:IPR020587" /db_xref="InterPro:IPR020588" /db_xref="InterPro:IPR023400" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10721" /db_xref="UniProtKB/Swiss-Prot:P16971" /translation="MSDRQAALDMALKQIEKQFGKGSIMKLGEKTDTRISTVPSGSLA LDTALGIGGYPRGRIIEVYGPESSGKTTVALHAIAEVQQQGGQAAFIDAEHALDPVYA QKLGVNIEELLLSQPDTGEQALEIAEALVRSGAVDIVVVDSVAALVPKAEIEGDMGDS HVGLQARLMSQALRKLSGAINKSKTIAIFINQIREKVGVMFGNPETTPGGRALKFYSS VRLEVRRAEQLKQGNDVMGNKTKIKVVKNKVAPPFRTAEVDIMYGEGISKEGEIIDLG TELDIVQKSGSWYSYEEERLGQGRENAKQFLKENKDIMLMIQEQIREHYGLDNNGVVQ QQAEETQEELEFEE*" /label="recA CDS" gene 1676973..1678019 /gene="recA" /locus_tag="BSU_16940" /old_locus_tag="BSU16940" /label="recA gene" downshifts 1678031 /Source="Nicolas_upshifts" /id="D913" /incds=0 /nref=201 /ntot=262 /MaxReadThrough="4.54659" /MaxDrop="9.405" /score="23.91264" /energy="-9.7" /TU="U1355" /idTUdmin="U1353" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" S_feature 1678076..1678141 /Source="Nicolas_S_feature" /locus_tag="new_1765748_1765813" /HighExp="S7, S5, S8, S4, H2O2, C30, T5.0H, S6, ferm, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="Sig-, SigA, SigA" /TUlongPSig="0.016, 0.998, 0.987" /label="S605" promotor_-35 1678113..1678122 /Source="Nicolas_upshift_promotors" /id="U1356" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2507 /SigmaFactorBS="caaaaaaatgataaaaatattgctttttttGACAACTTTTtt agggctttatTCGTCTAACAAAACGTgtgcaaaatggaatttattttgggaggaaaaa a" /listShort="pbpX, S606" /listLong="S607, ymdA, ymdB, S608, spoVS, S609, tdh, kbl, ymcB, ymcA" /label="promotor_-35" promotor_-10 1678135..1678150 /Source="Nicolas_upshift_promotors" /id="U1356" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2507 /SigmaFactorBS="caaaaaaatgataaaaatattgctttttttGACAACTTTTtt agggctttatTCGTCTAACAAAACGTgtgcaaaatggaatttattttgggaggaaaaa a" /listShort="pbpX, S606" /listLong="S607, ymdA, ymdB, S608, spoVS, S609, tdh, kbl, ymcB, ymcA" /label="promotor_-10" upshifts 1678143 /Source="Nicolas_upshifts" /id="U1356" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2507 /SigmaFactorBS="caaaaaaatgataaaaatattgctttttttGACAACTTTTtt agggctttatTCGTCTAACAAAACGTgtgcaaaatggaatttattttgggaggaaaaa a" /listShort="pbpX, S606" /listLong="S607, ymdA, ymdB, S608, spoVS, S609, tdh, kbl, ymcB, ymcA" /label="upshifts" CDS 1678187..1679362 /gene="pbpX" /locus_tag="BSU_16950" /old_locus_tag="BSU16950" /function="16.13: Shape" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:14762009, 15758244, 21856855" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14762009, 15758244, 21856855; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="penicillin-binding endopeptidase X (lysozyme resistance)" /protein_id="NP_389577.1" /db_xref="EnsemblGenomes-Gn:BSU16950" /db_xref="EnsemblGenomes-Tr:CAB13568" /db_xref="GOA:O31773" /db_xref="InterPro:IPR001466" /db_xref="InterPro:IPR012338" /db_xref="SubtiList:BG12642" /db_xref="UniProtKB/Swiss-Prot:O31773" /translation="MTSPTRRRTAKRRRRKLNKRGKLLFGLLAVMVCITIWNALHRNS EENEPSQETAAVSNTDQKKEVKKKTAKKSEEQIKTVDRNQKISNYLKEIGFSGTAMIV RNGEIVTNKGFGYADRKHYIQNNPLTSFYVGSSQKALIATAILQLEEKGKLQTSDPVS TYLPHFPNGQTITLKNLLTHTSGINGHIEGNGAITPDDLIKDIELQGIKRQPGVWDYK DSNYSVLAYIIAEVSGEPYEQYIKNHIFKPAGMTHAGFYKTYEKEPYPAVGYKMEGSK TVTPYIPDLSQLYGAGDIYMSAIDMYKFDQALIDGKLYSQKSYEKMFTPGSSSTYGMG FYVAPGSYSNHGVMPGFNILNSFSKSGQTIVILFSNIQNNAKLGQVNNKIYQLLNQE* " /label="pbpX CDS" gene 1678187..1679362 /gene="pbpX" /locus_tag="BSU_16950" /old_locus_tag="BSU16950" /label="pbpX gene" S_feature 1679363..1679462 /Source="Nicolas_S_feature" /locus_tag="new_1767035_1767134" /HighExp="dia0, LBGexp, Lbexp, Oxctl, Paraq, H2O2, C30, G150, Mt0, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.54369999999999996" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="SigA, Sig-, SigA, SigA" /TUlongPSig="1, 0.016, 0.998, 0.987" /label="S606" promotor_-35 1679436..1679443 /Source="Nicolas_upshift_promotors" /id="U1357" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.791208791208791" /psig=1 /xcortree=1906 /SigmaFactorBS="aagaagactggcctgcaaacgttaagatggcaAGCTTGACaa gtatttccgacACATTTACAATGAAGTTGTAacatttgtttttttaacatgattgtta a" /listShort="S607, ymdA, ymdB, S608, spoVS" /listLong="S609, tdh, kbl, ymcB, ymcA" /label="promotor_-35" promotor_-10 1679457..1679476 /Source="Nicolas_upshift_promotors" /id="U1357" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.791208791208791" /psig=1 /xcortree=1906 /SigmaFactorBS="aagaagactggcctgcaaacgttaagatggcaAGCTTGACaa gtatttccgacACATTTACAATGAAGTTGTAacatttgtttttttaacatgattgtta a" /listShort="S607, ymdA, ymdB, S608, spoVS" /listLong="S609, tdh, kbl, ymcB, ymcA" /label="promotor_-10" S_feature 1679464..1679637 /Source="Nicolas_S_feature" /locus_tag="new_1767136_1767309" /HighExp="M9-stat, T3.30H, BC, T2.0H, T3.0H, T-1.40H, T1.30H, T2.30H, T4.0H, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigWXY, SigA, Sig-, SigA, SigA" /TUlongPSig="1, 1, 0.016, 0.998, 0.987" /label="S607" upshifts 1679464 /Source="Nicolas_upshifts" /id="U1357" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.791208791208791" /psig=1 /xcortree=1906 /SigmaFactorBS="aagaagactggcctgcaaacgttaagatggcaAGCTTGACaa gtatttccgacACATTTACAATGAAGTTGTAacatttgtttttttaacatgattgtta a" /listShort="S607, ymdA, ymdB, S608, spoVS" /listLong="S609, tdh, kbl, ymcB, ymcA" /label="upshifts" CDS 1679638..1681200 /gene="rny" /locus_tag="BSU_16960" /old_locus_tag="BSU16960" /EC_number="3.1.26.-" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 17005971, 19779461, 21803996, 21815947, 21862575, 22720735, 25402410, 26797123" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17005971, 19779461, 21803996, 21815947, 21862575, 22720735, 25402410, 26797123; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endoribonuclease Y" /protein_id="NP_389578.1" /db_xref="EnsemblGenomes-Gn:BSU16960" /db_xref="EnsemblGenomes-Tr:CAB13569" /db_xref="GOA:O31774" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR004087" /db_xref="InterPro:IPR004088" /db_xref="InterPro:IPR006674" /db_xref="InterPro:IPR006675" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR017705" /db_xref="InterPro:IPR022711" /db_xref="InterPro:IPR036612" /db_xref="SubtiList:BG13420" /db_xref="UniProtKB/Swiss-Prot:O31774" /translation="MTPIMMVLISILLILLGLVVGYFVRKTIAEAKIAGARGAAEQIL EDAKRDAEALKKEALLEAKDEIHKLRIDAEQEVRERRNELQKQENRLLQKEENLDRKH EGIDKREAMLEKKDHSLNERQQHIEEMESKVDEMIRMQQSELERISSLTRDEAKQIIL ERVENELSHDIAIMTKETENRAKEEADKKAKNILSLALQRCAADHVAETTVSVVNLPN DEMKGRIIGREGRNIRTLETLTGIDLIIDDTPEAVILSGFDPIRRETARIALDKLVQD GRIHPARIEEMVEKSRREVDDYIREMGEQTTFEVGVHGLHPDLIKILGRLKFRTSYGQ NVLKHSMEVAFLAGLMASELGEDAKLAKRAGLLHDIGKAIDHEVEGSHVEIGVELATK YKEHPVVINSIASHHGDEEPTSIIAVLVAAADALSAARPGARSETLENYIRRLEKLEE ISESYEGVEKSFAIQAGREVRIMVKPDSINDLEAHRLARDIRKRIEDELDYPGHIKVT VIRETRAVEYAK*" /label="rny CDS" gene 1679638..1681200 /gene="rny" /locus_tag="BSU_16960" /old_locus_tag="BSU16960" /label="rny gene" downshifts 1681177 /Source="Nicolas_upshifts" /id="D914" /incds=0 /nref=243 /ntot=268 /MaxReadThrough="5.32126" /MaxDrop="5.3789" /score="10.4712371" /energy="-9" /TU="U1357" /idTUdmin="U1357" /TUdmin="-1342" /isTUend="FALSE" /label="downshifts" CDS 1681269..1682063 /gene="pdeB" /locus_tag="BSU_16970" /old_locus_tag="BSU16970" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:19376879, 21856853, 24163345, 26904951, 26906740" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19376879, 21856853, 24163345, 26904951, 26906740; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2'3' and 3'5' cyclic nucleotide monophosphates phosphodiesterase involved in biofilm formation" /protein_id="NP_389579.2" /db_xref="EnsemblGenomes-Gn:BSU16970" /db_xref="EnsemblGenomes-Tr:CAB13570" /db_xref="GOA:O31775" /db_xref="InterPro:IPR005235" /db_xref="InterPro:IPR029052" /db_xref="PDB:4B2O" /db_xref="SubtiList:BG13421" /db_xref="UniProtKB/Swiss-Prot:O31775" /translation="MRILFIGDVVGSPGRDMVKEYVPKLKTKYKPHFTIINGENAAHG KGLTEKIYHSLIQSGADAITMGNHTWDKKEIFDFIDDVPNLVRPANFPEGTPGKGITY VKANGKELAVINLQGRTFLPPLDDPFLKADELIAEAAKRTPYIFIDFHAEATSEKLAL GWYTDGRASAVVGTHTHVQTADNRILPKGTAYITDVGMTGPYDGILGMDRETIIKRFK TNLPVRFTVAEGKTTLSGVVIDIDDQTKKAVKIERILINDDHMFFE*" /label="pdeB CDS" gene 1681269..1682063 /gene="pdeB" /locus_tag="BSU_16970" /old_locus_tag="BSU16970" /label="pdeB gene" promotor_-35 1681818..1681823 /Source="Nicolas_upshift_promotors" /id="U1358" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.91008991008991" /psig="0.91008991008991" /xcortree=1456 /SigmaFactorBS="cgtgcaaacagcggataacCGCATTttgccgaagggaacgGC ATATATTACTGATGTGGgaatgactggcccgtatgacggtatactggggatggacaga g" /listShort="S608, spoVS, S609" /listLong="tdh, kbl, ymcB, ymcA" /label="promotor_-35" promotor_-10 1681839..1681857 /Source="Nicolas_upshift_promotors" /id="U1358" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.91008991008991" /psig="0.91008991008991" /xcortree=1456 /SigmaFactorBS="cgtgcaaacagcggataacCGCATTttgccgaagggaacgGC ATATATTACTGATGTGGgaatgactggcccgtatgacggtatactggggatggacaga g" /listShort="S608, spoVS, S609" /listLong="tdh, kbl, ymcB, ymcA" /label="promotor_-10" upshifts 1681859 /Source="Nicolas_upshifts" /id="U1358" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.91008991008991" /psig="0.91008991008991" /xcortree=1456 /SigmaFactorBS="cgtgcaaacagcggataacCGCATTttgccgaagggaacgGC ATATATTACTGATGTGGgaatgactggcccgtatgacggtatactggggatggacaga g" /listShort="S608, spoVS, S609" /listLong="tdh, kbl, ymcB, ymcA" /label="upshifts" promotor_-35 1682107..1682112 /Source="Nicolas_upshift_promotors" /id="U1359" /multdbtbs="SigH" /comp="M3" /sig="SigEF" /pcomp="0.916083916083916" /psig="0.916083916083916" /xcortree=759 /SigmaFactorBS="gttgaacatatggttattttataaaaatattaaaaagaaaag caGGAATAtagcaactccttagtGAATATAGTAAAAATGGAAggtagcccgctatttt t" /listShort="S608, spoVS, S609, tdh" /listLong="kbl, ymcB, ymcA" /label="promotor_-35" S_feature 1682123..1682262 /Source="Nicolas_S_feature" /locus_tag="new_1769795_1769934" /HighExp="T5.0H, LoTm, BT, B60, S8, M9-stat, S6, BC, B36, S4" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigEF, SigA" /TUshortPSig="0.916, 0.91, 1" /TUlongSig="SigWXY, SigA, Sig-, SigA, SigA" /TUlongPSig="1, 1, 0.016, 0.998, 0.987" /label="S608" upshifts 1682123 /Source="Nicolas_upshifts" /id="U1359" /multdbtbs="SigH" /comp="M3" /sig="SigEF" /pcomp="0.916083916083916" /psig="0.916083916083916" /xcortree=759 /SigmaFactorBS="gttgaacatatggttattttataaaaatattaaaaagaaaag caGGAATAtagcaactccttagtGAATATAGTAAAAATGGAAggtagcccgctatttt t" /listShort="S608, spoVS, S609, tdh" /listLong="kbl, ymcB, ymcA" /label="upshifts" promotor_-10 1682128..1682146 /Source="Nicolas_upshift_promotors" /id="U1359" /multdbtbs="SigH" /comp="M3" /sig="SigEF" /pcomp="0.916083916083916" /psig="0.916083916083916" /xcortree=759 /SigmaFactorBS="gttgaacatatggttattttataaaaatattaaaaagaaaag caGGAATAtagcaactccttagtGAATATAGTAAAAATGGAAggtagcccgctatttt t" /listShort="S608, spoVS, S609, tdh" /listLong="kbl, ymcB, ymcA" /label="promotor_-10" upshifts complement(1682155) /Source="Nicolas_upshifts" /id="U1360" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.763236763236763" /psig="0.0679320679320679" /xcortree=695 /SigmaFactorBS="acaatcattattagatgttgctaTCCAAaaagccatCCCCAC AATGCTTTtcaaaaatagcgggctaccttccatttttactatattcactaaggagttg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1682166..1682179) /Source="Nicolas_upshift_promotors" /id="U1360" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.763236763236763" /psig="0.0679320679320679" /xcortree=695 /SigmaFactorBS="acaatcattattagatgttgctaTCCAAaaagccatCCCCAC AATGCTTTtcaaaaatagcgggctaccttccatttttactatattcactaaggagttg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1682188..1682192) /Source="Nicolas_upshift_promotors" /id="U1360" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.763236763236763" /psig="0.0679320679320679" /xcortree=695 /SigmaFactorBS="acaatcattattagatgttgctaTCCAAaaagccatCCCCAC AATGCTTTtcaaaaatagcgggctaccttccatttttactatattcactaaggagttg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(1682199) /Source="Nicolas_upshifts" /id="D915" /incds=0 /nref=5 /ntot=35 /MaxReadThrough="1.51152" /MaxDrop="3.63977" /score="3.80280375" /energy="-6.7" /TU="NA" /idTUdmin="U1366" /TUdmin=10274 /isTUend="FALSE" /label="downshifts" CDS 1682263..1682523 /gene="spoVS" /locus_tag="BSU_16980" /old_locus_tag="BSU16980" /function="16.3: Control" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:7559352, 16428420, 18562273" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7559352, 16428420, 18562273; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator required for dehydratation of the spore core and assembly of the coat (stage V sporulation)" /protein_id="NP_389580.1" /db_xref="EnsemblGenomes-Gn:BSU16980" /db_xref="EnsemblGenomes-Tr:CAB13571" /db_xref="GOA:P45693" /db_xref="InterPro:IPR007347" /db_xref="SubtiList:BG11245" /db_xref="UniProtKB/Swiss-Prot:P45693" /translation="MEILKVSAKSSPNSVAGALAGVLRERGAAEIQAIGAGALNQAVK AVAIARGFVAPSGVDLICIPAFTDIQIDGEERTAIKLIVEPR*" /label="spoVS CDS" gene 1682263..1682523 /gene="spoVS" /locus_tag="BSU_16980" /old_locus_tag="BSU16980" /label="spoVS gene" downshifts 1682475 /Source="Nicolas_upshifts" /id="D916" /incds=0 /nref=1 /ntot=27 /MaxReadThrough="8.31914" /MaxDrop="4.27515" /score="5.18548432" /energy="-12.5" /TU="U1357,U1358,U1359" /idTUdmin="U1357" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" downshifts complement(1682507) /Source="Nicolas_upshifts" /id="D917" /incds=0 /nref=3 /ntot=15 /MaxReadThrough="1.16149" /MaxDrop="3.88837" /score="3.80280375" /energy="-6.7" /TU="NA" /idTUdmin="U1366" /TUdmin=9966 /isTUend="FALSE" /label="downshifts" downshifts 1682519 /Source="Nicolas_upshifts" /id="D918" /incds=0 /nref=171 /ntot=265 /MaxReadThrough="4.08266" /MaxDrop="5.124" /score="5.18548432" /energy="-12.5" /TU="U1358,U1359" /idTUdmin="U1357" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 1682564..1682738 /Source="Nicolas_S_feature" /locus_tag="new_1770236_1770410" /HighExp="S6, S8, S7, M9-stat, Lbstat, BT, S5, T1.30H, T2.0H, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigEF" /TUshortPSig="0.916, 0.91" /TUlongSig="SigA, SigWXY" /TUlongPSig="1, 1" /label="S609" promotor_-35 1682722..1682729 /Source="Nicolas_upshift_promotors" /id="U1361" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.825174825174825" /psig="0.999000999001" /xcortree=322 /SigmaFactorBS="ttttcaagacagatacttttgtccttctggaaaagacagttc TGTTTACGcttattccatatcaTGGTACAATCCGAATATAACaagaatttttcaagga g" /listShort="tdh, kbl, ymcB, ymcA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1682740 /Source="Nicolas_upshifts" /id="U1361" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.825174825174825" /psig="0.999000999001" /xcortree=322 /SigmaFactorBS="ttttcaagacagatacttttgtccttctggaaaagacagttc TGTTTACGcttattccatatcaTGGTACAATCCGAATATAACaagaatttttcaagga g" /listShort="tdh, kbl, ymcB, ymcA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1682744..1682763 /Source="Nicolas_upshift_promotors" /id="U1361" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.825174825174825" /psig="0.999000999001" /xcortree=322 /SigmaFactorBS="ttttcaagacagatacttttgtccttctggaaaagacagttc TGTTTACGcttattccatatcaTGGTACAATCCGAATATAACaagaatttttcaagga g" /listShort="tdh, kbl, ymcB, ymcA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1682789..1683832 /gene="tdh" /locus_tag="BSU_16990" /old_locus_tag="BSU16990" /EC_number="1.1.1.103" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8519804, 16817900, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="threonine 3-dehydrogenase" /protein_id="NP_389581.1" /db_xref="EnsemblGenomes-Gn:BSU16990" /db_xref="EnsemblGenomes-Tr:CAB13572" /db_xref="GOA:O31776" /db_xref="InterPro:IPR002328" /db_xref="InterPro:IPR004627" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR020843" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12685" /db_xref="UniProtKB/Swiss-Prot:O31776" /translation="MQSGKMKALMKKDGAFGAVLTEVPIPEIDKHEVLIKVKAASICG TDVHIYNWDQWARQRIKTPYVFGHEFSGIVEGVGENVSSVKVGEYVSAETHIVCGECV PCLTGKSHVCTNTAIIGVDTAGCFAEYVKVPADNIWRNPADMDPSIASIQEPLGNAVH TVLESQPAGGTTAVIGCGPIGLMAVAVAKAAGASQVIAIDKNEYRLRLAKQMGATCTV SIEKEDPLKIVSALTSGEGADLVCEMSGHPSAIAQGLAMAANGGRFHILSLPEHPVTI DLTNKVVFKGLTIQGITGRKMFSTWRQVSQLISSNMIDLAPVITHQFPLEEFEKGFEL MRSGQCGKVILIP*" /label="tdh CDS" gene 1682789..1683832 /gene="tdh" /locus_tag="BSU_16990" /old_locus_tag="BSU16990" /label="tdh gene" CDS 1683845..1685023 /gene="kbl" /locus_tag="BSU_17000" /old_locus_tag="BSU17000" /EC_number="2.3.1.29" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17146529, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-amino-3-ketobutyrate CoA ligase (glycine acetyl transferase)" /protein_id="NP_389582.1" /db_xref="EnsemblGenomes-Gn:BSU17000" /db_xref="EnsemblGenomes-Tr:CAB13573" /db_xref="GOA:O31777" /db_xref="InterPro:IPR001917" /db_xref="InterPro:IPR004723" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR010962" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG12610" /db_xref="UniProtKB/Swiss-Prot:O31777" /translation="MTKEFEFLKAELNSMKENHTWQDIKQLESMQGPSVTVNHQKVIQ LSSNNYLGFTSHPRLINAAQEAVQQYGAGTGSVRTIAGTFTMHQELEKKLAAFKKTEA ALVFQSGFTTNQGVLSSILSKEDIVISDELNHASIIDGIRLTKADKKVYQHVNMSDLE RVLRKSMNYRMRLIVTDGVFSMDGNIAPLPDIVELAEKYDAFVMVDDAHASGVLGENG RGTVNHFGLDGRVHIQVGTLSKAIGVLGGYAAGSKVLIDYLRHKGRPFLFSTSHPPAV TAACMEAIDVLLEEPEHMERLWENTAYFKAMLVKMGLTLTKSETPILPILIGDEGVAK QFSDQLLSRGVFAQSIVFPTVAKGKARIRTIITAEHTKDELDQALDVIEKTAKELQLL *" /label="kbl CDS" gene 1683845..1685023 /gene="kbl" /locus_tag="BSU_17000" /old_locus_tag="BSU17000" /label="kbl gene" downshifts 1685005 /Source="Nicolas_upshifts" /id="D919" /incds=0 /nref=3 /ntot=25 /MaxReadThrough="5.75732" /MaxDrop="3.4918" /score="4.73069387" /energy="-12.5" /TU="U1361" /idTUdmin="U1359" /TUdmin=1936 /isTUend="FALSE" /label="downshifts" promotor_-35 1685103..1685106 /Source="Nicolas_upshift_promotors" /id="U1362" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.681318681318681" /psig=1 /xcortree=2732 /SigmaFactorBS="ttccttattgattattattctcaatgagtgtacaatgatagg ttgccaGTTGtgcagagcttcaatAACCTTTATACTGAAGGGTGgaagtttggtttga a" /listShort="ymcB, ymcA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1685115 /Source="Nicolas_upshifts" /id="U1362" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.681318681318681" /psig=1 /xcortree=2732 /SigmaFactorBS="ttccttattgattattattctcaatgagtgtacaatgatagg ttgccaGTTGtgcagagcttcaatAACCTTTATACTGAAGGGTGgaagtttggtttga a" /listShort="ymcB, ymcA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1685121..1685140 /Source="Nicolas_upshift_promotors" /id="U1362" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.681318681318681" /psig=1 /xcortree=2732 /SigmaFactorBS="ttccttattgattattattctcaatgagtgtacaatgatagg ttgccaGTTGtgcagagcttcaatAACCTTTATACTGAAGGGTGgaagtttggtttga a" /listShort="ymcB, ymcA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1685171..1686700 /gene="miaB" /locus_tag="BSU_17010" /old_locus_tag="BSU17010" /EC_number="2.8.4.3" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:15175311, 18307109, 20472640, 20584901, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15175311, 18307109, 20472640, 20584901, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enzyme for ms(2)i(6)A formation for tRNA modification" /protein_id="NP_389583.1" /db_xref="EnsemblGenomes-Gn:BSU17010" /db_xref="EnsemblGenomes-Tr:CAB13574" /db_xref="GOA:O31778" /db_xref="InterPro:IPR002792" /db_xref="InterPro:IPR005839" /db_xref="InterPro:IPR006463" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013848" /db_xref="InterPro:IPR020612" /db_xref="InterPro:IPR023404" /db_xref="SubtiList:BG13418" /db_xref="UniProtKB/Swiss-Prot:O31778" /translation="MNEKQKLESGQVHPSDKKSEKDYSKYFEAVYIPPSLKDAKKRGK EAVTYHNDFKISEQFKGLGDGRKFYIRTYGCQMNEHDTEVMAGIFMALGYEATNSVDD ANVILLNTCAIRENAENKVFGELGHLKALKKNNPDLILGVCGCMSQEESVVNRILKKH PFVDMIFGTHNIHRLPELLSEAYLSKEMVVEVWSKEGDVIENLPKVRNGKIKGWVNIM YGCDKFCTYCIVPYTRGKERSRRPEDIIQEVRRLASEGYKEITLLGQNVNAYGKDFED MTYGLGDLMDELRKIDIPRIRFTTSHPRDFDDRLIEVLAKGGNLLDHIHLPVQSGSSE VLKLMARKYDRERYMELVRKIKEAMPNASLTTDIIVGFPNETDEQFEETLSLYREVEF DSAYTFIYSPREGTPAAKMKDNVPMRVKKERLQRLNALVNEISAKKMKEYEGKVVEVL VEGESKNNPDILAGYTEKSKLVNFKGPKEAIGKIVRVKIQQAKTWSLDGEMVGEAIEV K*" /label="miaB CDS" gene 1685171..1686700 /gene="miaB" /locus_tag="BSU_17010" /old_locus_tag="BSU17010" /label="miaB gene" CDS 1686702..1687133 /gene="ricA" /locus_tag="BSU_17020" /old_locus_tag="BSU17020" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10712692, 15175311, 15661000, 22720735, 23490197, 26434553, 27501195, 28295778" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10712692, 15175311, 15661000, 22720735, 23490197, 26434553, 27501195, 28295778; Product type r: regulator" /codon_start=1 /transl_table=11 /product="master regulator for biofilm formation via regulation of RNase Y (RicAFT complex / FAD / two [4Fe-4S]2+)" /protein_id="NP_389584.1" /db_xref="EnsemblGenomes-Gn:BSU17020" /db_xref="EnsemblGenomes-Tr:CAB13575" /db_xref="InterPro:IPR010368" /db_xref="InterPro:IPR016783" /db_xref="InterPro:IPR023378" /db_xref="PDB:2PIH" /db_xref="SubtiList:BG13417" /db_xref="UniProtKB/Swiss-Prot:O31779" /translation="MTLYSKKDIVQQARNLAKMISETEEVDFFKRAEAQINENDKVST IVNQIKALQKQAVNLKHYEKHEALKQVEAKIDALQEELEEIPVIQEFRDSQMEVNDLL QLVAHTISNQVTNEIITSTGGDLLKGETGSKVKHSNNSCSL*" /label="ricA CDS" gene 1686702..1687133 /gene="ricA" /locus_tag="BSU_17020" /old_locus_tag="BSU17020" /label="ricA gene" downshifts 1687116 /Source="Nicolas_upshifts" /id="D920" /incds=0 /nref=255 /ntot=267 /MaxReadThrough="0.9572" /MaxDrop="7.73043" /score="21.1260722" /energy="-10.3" /TU="NA" /idTUdmin="U1361" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 1687264..1687269 /Source="Nicolas_upshift_promotors" /id="U1363" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1090 /SigmaFactorBS="cagccgcgtataaactttatcgcacttataaGTAAAGtttct aggcacccctGCATACAATGGAACAGAAActttgtatttttatattttatttataaaa a" /listShort="S610, cotE, mutS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1687285..1687303 /Source="Nicolas_upshift_promotors" /id="U1363" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1090 /SigmaFactorBS="cagccgcgtataaactttatcgcacttataaGTAAAGtttct aggcacccctGCATACAATGGAACAGAAActttgtatttttatattttatttataaaa a" /listShort="S610, cotE, mutS" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1687293..1687394 /Source="Nicolas_S_feature" /locus_tag="new_1774965_1775066" /HighExp="S3, S5, S8, S4, S6, S7, B36, BT, Pyr, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S610" upshifts 1687293 /Source="Nicolas_upshifts" /id="U1363" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1090 /SigmaFactorBS="cagccgcgtataaactttatcgcacttataaGTAAAGtttct aggcacccctGCATACAATGGAACAGAAActttgtatttttatattttatttataaaa a" /listShort="S610, cotE, mutS" /GFF_Attribute="listLong" /label="upshifts" CDS 1687395..1687940 /gene="cotE" /locus_tag="BSU_17030" /old_locus_tag="BSU17030" /function="16.13: Shape" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11737650, 14563859, 14973022, 17172339, 20023017, 22773792, 25259857, 26821119, 27320701" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11737650, 14563859, 14973022, 17172339, 20023017, 22773792, 25259857, 26821119, 27320701; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="morphogenic spore protein" /protein_id="NP_389585.1" /db_xref="EnsemblGenomes-Gn:BSU17030" /db_xref="EnsemblGenomes-Tr:CAB13576" /db_xref="GOA:P14016" /db_xref="InterPro:IPR018901" /db_xref="SubtiList:BG10494" /db_xref="UniProtKB/Swiss-Prot:P14016" /translation="MSEYREIITKAVVAKGRKFTQCTNTISPEKKPSSILGGWIINHK YDAEKIGKTVEIEGYYDINVWYSYADNTKTEVVTERVKYVDVIKLRYRDNNYLDDEHE VIAKVLQQPNCLEVTISPNGNKIVVQAEREFLAEVVGETKVVVEVNPDWEEDDEEDWE DELDEELEDINPEFLVGDPEE*" /label="cotE CDS" gene 1687395..1687940 /gene="cotE" /locus_tag="BSU_17030" /old_locus_tag="BSU17030" /label="cotE gene" downshifts 1687934 /Source="Nicolas_upshifts" /id="D921" /incds=0 /nref=64 /ntot=97 /MaxReadThrough="4.37388" /MaxDrop="8.23792" /score="10.7927556" /energy="-12.6" /TU="U1363" /idTUdmin="U1363" /TUdmin="-745" /isTUend="FALSE" /label="downshifts" downshifts complement(1687941) /Source="Nicolas_upshifts" /id="D922" /incds=0 /nref=1 /ntot=4 /MaxReadThrough="4.21458" /MaxDrop="3.44208" /score="12.3953461" /energy="-11.4" /TU="NA" /idTUdmin="U1366" /TUdmin=4532 /isTUend="FALSE" /label="downshifts" promotor_-35 1687998..1688001 /Source="Nicolas_upshift_promotors" /id="U1364" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2577 /SigmaFactorBS="agtacccccaagtctcttttttatattgatatatcattCTTT tatcactttttgttTATGTTATAATGAAGGTTGGaaaatagaaacgttgatacatagt g" /listShort="mutS, mutL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1688016..1688035 /Source="Nicolas_upshift_promotors" /id="U1364" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2577 /SigmaFactorBS="agtacccccaagtctcttttttatattgatatatcattCTTT tatcactttttgttTATGTTATAATGAAGGTTGGaaaatagaaacgttgatacatagt g" /listShort="mutS, mutL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1688020 /Source="Nicolas_upshifts" /id="U1364" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2577 /SigmaFactorBS="agtacccccaagtctcttttttatattgatatatcattCTTT tatcactttttgttTATGTTATAATGAAGGTTGGaaaatagaaacgttgatacatagt g" /listShort="mutS, mutL" /GFF_Attribute="listLong" /label="upshifts" CDS 1688073..1690649 /gene="mutS" /locus_tag="BSU_17040" /old_locus_tag="BSU17040" /function="16.5: Explore" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15375129, 16269814, 23998896, 26343983" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15375129, 16269814, 23998896, 26343983; Product type f: factor" /codon_start=1 /transl_table=11 /product="DNA mismatch repair recognition factor" /protein_id="NP_389586.2" /db_xref="EnsemblGenomes-Gn:BSU17040" /db_xref="EnsemblGenomes-Tr:CAB13577" /db_xref="GOA:P49849" /db_xref="InterPro:IPR000432" /db_xref="InterPro:IPR005748" /db_xref="InterPro:IPR007695" /db_xref="InterPro:IPR007696" /db_xref="InterPro:IPR007860" /db_xref="InterPro:IPR007861" /db_xref="InterPro:IPR016151" /db_xref="InterPro:IPR017261" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036187" /db_xref="InterPro:IPR036678" /db_xref="SubtiList:BG11403" /db_xref="UniProtKB/Swiss-Prot:P49849" /translation="MAGYTPMIQQYLKIKAEHQDAFLFFRLGDFYEMFFEDAKKASQE LEITLTSRDGGAAEKIPMCGVPYHSASAYIEQLIKKGYKVAICEQTEDPKAAKGVVKR EVVQLITPGTVMDGKGIHESENNFIASVSACSNGYGLALSDLTTGENLAVLIERLEDV ISEIYSVGAREIVVSGSLDADTVAQLRERCGATISIEDGETDEHVTIIEHLNNEDITK TFLRLYTYLKRTQKRSLDHLQPVQVYELEEAMKIDLYSKRNLELTETIRSKNKKGSLL WLLDETKTAMGGRLLKQWIDRPLIRVNQIEERQEMVETLMSHFFEREDLRERLKEVYD LERLAGRVAFGNVNARDLIQLKESLKQVPGIKQLVASLAHDKAKERAKRIDPCGDVLE LLEEALYENPPLSVKEGNLIKDGYNQKLDEYRDASRNGKDWIARLEQQEREYTGIRSL KVGFNKVFGYYIEVTKANLHLLEEGRYERKQTLTNAERYITPELKEKEALILEAENNI CELEYELFTELREKVKQYIPRLQQLAKQMSELDALQCFATISENRHYTKPEFSKDEVE VIEGRHPVVEKVMDSQEYVPNNCMMGDNRQMLLITGPNMSGKSTYMRQIALISIMAQI GCFVPAKKAVLPIFDQIFTRIGAADDLISGQSTFMVEMLEAKNAIVNATKNSLILFDE IGRGTSTYDGMALAQAIIEYVHDHIGAKTLFSTHYHELTVLEDKLPQLKNVHVRAEEY NGTVVFLHQIKEGAADKSYGIHVAQLAELPGDLIARAQDILKELEHSGNKPEVPVQKP QVKEEPAQLSFFDEAEKPAETPKLSKKEKQVIDAFKSLNILDMTPLEAMNEMYKLQKK LH*" /label="mutS CDS" gene 1688073..1690649 /gene="mutS" /locus_tag="BSU_17040" /old_locus_tag="BSU17040" /label="mutS gene" CDS 1690665..1692548 /gene="mutL" /locus_tag="BSU_17050" /old_locus_tag="BSU17050" /function="16.8: Protect" /function="16.5: Explore" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:15375129, 22843852, 26343983, 26384423, 27369079" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15375129, 22843852, 26343983, 26384423, 27369079; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA mismatch repair endonuclease" /protein_id="NP_389587.1" /db_xref="EnsemblGenomes-Gn:BSU17050" /db_xref="EnsemblGenomes-Tr:CAB13578" /db_xref="GOA:P49850" /db_xref="InterPro:IPR002099" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR013507" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR014762" /db_xref="InterPro:IPR014790" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR020667" /db_xref="InterPro:IPR036890" /db_xref="InterPro:IPR037198" /db_xref="PDB:3GAB" /db_xref="PDB:3KDG" /db_xref="PDB:3KDK" /db_xref="SubtiList:BG11402" /db_xref="UniProtKB/Swiss-Prot:P49850" /translation="MAKVIQLSDELSNKIAAGEVVERPASVVKELVENAIDADSTVIE IDIEEAGLASIRVLDNGEGMENEDCKRAFRRHATSKIKDENDLFRVRTLGFRGEALPS IASVSHLEITTSTGEGAGTKLVLQGGNIISESRSSSRKGTEIVVSNLFFNTPARLKYM KTVHTELGNITDVVNRIALAHPEVSIRLRHHGKNLLQTNGNGDVRHVLAAIYGTAVAK KMLPLHVSSLDFEVKGYIALPEITRASRNYMSSVVNGRYIKNFPLVKAVHEGYHTLLP IGRHPITFIEITMDPILVDVNVHPSKLEVRLSKETELHDLIRDGIKDVFKQQQLIPSA QVPKKSAPAIKNEQQFITFDEKPPEKKVPEKSTAPSYSPMKLSSVVKEPVDAEEKLPP LQFDAPPIVDQEQTLEVSDVSAEQPETFEQECHEEQPQPASDRVPIMYPIGQMHGTYI LAQNENGLYIIDQHAAQERIKYEYFREKVGEVEPEVQEMIVPLTFHYSTNEALIIEQH KQELESVGVFLESFGSNSYIVRCHPAWFPKGEEAELIEEIIQQVLDSKNIDIKKLREE AAIMMSCKGSIKANRHLRNDEIKALLDDLRSTSDPFTCPHGRPIIIHHSTYEMEKMFK RVM*" /label="mutL CDS" gene 1690665..1692548 /gene="mutL" /locus_tag="BSU_17050" /old_locus_tag="BSU17050" /label="mutL gene" S_feature complement(1692451..1692945) /Source="Nicolas_S_feature" /locus_tag="new_1780123_1780617_c" /HighExp="M9-stat, LBGstat, LPhT, T2.0H, Lbstat, C30, T2.30H, M0t90, T1.30H, HiOs" /AntisenseName="mutL" /AntisenseCor="0.27126904061692803" /AntisenseRegPval="-5.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S611" downshifts 1692463 /Source="Nicolas_upshifts" /id="D923" /incds=1 /nref=216 /ntot=257 /MaxReadThrough="2.0064" /MaxDrop="5.37369" /score="33.4967163" /energy="-18.6" /TU="NA" /idTUdmin="U1364" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1692473) /Source="Nicolas_upshifts" /id="D924" /incds=1 /nref=3 /ntot=100 /MaxReadThrough="1.93338" /MaxDrop="2.7192" /score="27.1353816" /energy="-13.5" /TU="NA" /idTUdmin="U1366" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1692695..1692702 /Source="Nicolas_upshift_promotors" /id="U1365" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.861138861138861" /psig=1 /xcortree=478 /SigmaFactorBS="tcatggttcctccgtataacaaaatttcCATTTACAggcaat tgggattaATGTATATTTTGGGTGAGGGggtggaaacatatggcatgtggtccgaaga t" /listShort="S612" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1692717..1692736 /Source="Nicolas_upshift_promotors" /id="U1365" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.861138861138861" /psig=1 /xcortree=478 /SigmaFactorBS="tcatggttcctccgtataacaaaatttcCATTTACAggcaat tgggattaATGTATATTTTGGGTGAGGGggtggaaacatatggcatgtggtccgaaga t" /listShort="S612" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1692727..1692860 /Source="Nicolas_S_feature" /locus_tag="new_1780399_1780532" /HighExp="LoTm, T0.30H, T1.30H, M9-stat, T3.0H, BC, T1.0H, B60, B36, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99494800000000005" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S612" upshifts 1692727 /Source="Nicolas_upshifts" /id="U1365" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.861138861138861" /psig=1 /xcortree=478 /SigmaFactorBS="tcatggttcctccgtataacaaaatttcCATTTACAggcaat tgggattaATGTATATTTTGGGTGAGGGggtggaaacatatggcatgtggtccgaaga t" /listShort="S612" /GFF_Attribute="listLong" /label="upshifts" misc_RNA complement(1692732..1692882) /gene="surX" /locus_tag="BSU_misc_RNA_89" /product="small untranslated RNA of unknown function" /note="Evidence 5: Unknown function; PubMedId : 20525796, 23155385" /label="surX RNA" gene complement(1692732..1692882) /gene="surX" /locus_tag="BSU_misc_RNA_89" /label="surX gene" downshifts 1692817 /Source="Nicolas_upshifts" /id="D925" /incds=0 /nref=19 /ntot=136 /MaxReadThrough="3.45962" /MaxDrop="4.12444" /score="29.4045648" /energy="-15.3" /TU="U1365" /idTUdmin="U1364" /TUdmin=354 /isTUend="FALSE" /label="downshifts" CDS complement(1692946..1693401) /gene="ymzD" /locus_tag="BSU_17060" /old_locus_tag="BSU17060" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="YP_054578.1" /db_xref="EnsemblGenomes-Gn:BSU17060" /db_xref="EnsemblGenomes-Tr:CAE01453" /db_xref="GOA:Q7WY71" /db_xref="InterPro:IPR025912" /db_xref="SubtiList:BG14188" /db_xref="UniProtKB/Swiss-Prot:Q7WY71" /translation="MNQKEQNEHSKDFNLRSKLIGIVSITFIAAIALAVIFGGFFFGM KGLFSILGITYASNQTLALFILACFAVGLIIDPLTKIISIILAKSLSLKKTALFAFIL YFISNLITICFADYFMQSIYIPDVLLVVISAFMAIIELAFDNQPNREAA*" /label="ymzD CDS" gene complement(1692946..1693401) /gene="ymzD" /locus_tag="BSU_17060" /old_locus_tag="BSU17060" /label="ymzD gene" S_feature complement(1693402..1693493) /Source="Nicolas_S_feature" /locus_tag="new_1781074_1781165_c" /HighExp="LBGstat, M9-stat, T1.0H, T1.30H, T2.0H, M0t90, MG 150, LPhT, T3.0H, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S613" promotor_-10 complement(1693481..1693500) /Source="Nicolas_upshift_promotors" /id="U1366" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.537462537462537" /psig="0.999000999001" /xcortree=3231 /SigmaFactorBS="tgatgaaaaaggcccttccccagtggaaagggcCTTTtttgg ttttgttaaaaTATGCTATACTATTTTCGTCagaaaacagacttatagatattttggg c" /listShort="S613, ymzD, S611" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1693493) /Source="Nicolas_upshifts" /id="U1366" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.537462537462537" /psig="0.999000999001" /xcortree=3231 /SigmaFactorBS="tgatgaaaaaggcccttccccagtggaaagggcCTTTtttgg ttttgttaaaaTATGCTATACTATTTTCGTCagaaaacagacttatagatattttggg c" /listShort="S613, ymzD, S611" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1693517..1693520) /Source="Nicolas_upshift_promotors" /id="U1366" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.537462537462537" /psig="0.999000999001" /xcortree=3231 /SigmaFactorBS="tgatgaaaaaggcccttccccagtggaaagggcCTTTtttgg ttttgttaaaaTATGCTATACTATTTTCGTCagaaaacagacttatagatattttggg c" /listShort="S613, ymzD, S611" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1693556..1694113) /gene="ymcC" /locus_tag="BSU_17070" /old_locus_tag="BSU17070" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_389588.1" /db_xref="EnsemblGenomes-Gn:BSU17070" /db_xref="EnsemblGenomes-Tr:CAB13579" /db_xref="GOA:O31780" /db_xref="SubtiList:BG13419" /db_xref="UniProtKB/Swiss-Prot:O31780" /translation="MNGIAWMIVFCEIAFWVVIVLGLAVRYVFKRHTLGLLFLALTPV IDLILLAATGVDLYRGASATAAHGIAAVYIGISIAYGKQMIQWADEKFQYYVTKKGTK PLKRFGMDHAKHGAKGWLRHVLAYLIGAGLLAGMIYFINDSSRTEALSGILKLWTVII GIDFLITASYFIWPKKEKASANLRS*" /label="ymcC CDS" gene complement(1693556..1694113) /gene="ymcC" /locus_tag="BSU_17070" /old_locus_tag="BSU17070" /label="ymcC gene" promotor_-35 1694197..1694204 /Source="Nicolas_upshift_promotors" /id="U1367" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.404595404595405" /psig=1 /xcortree=3145 /SigmaFactorBS="ccatctttgtttttgtaacacaactgtattataaaAATTGCC CtctcatttttttCTTGTTACAATAAAGCTATGccaaaacaaattgaccatgagaaaa g" /listShort="pksA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1694217..1694236 /Source="Nicolas_upshift_promotors" /id="U1367" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.404595404595405" /psig=1 /xcortree=3145 /SigmaFactorBS="ccatctttgtttttgtaacacaactgtattataaaAATTGCC CtctcatttttttCTTGTTACAATAAAGCTATGccaaaacaaattgaccatgagaaaa g" /listShort="pksA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1694219..1694237) /Source="Nicolas_upshift_promotors" /id="U1368" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1400 /SigmaFactorBS="gcgccacgttgcttctgcaatttgttttcttcttttCTCATG gtcaatttgttttgGCATAGCTTTATTGTAACAagaaaaaaatgagagggcaattttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1694222 /Source="Nicolas_upshifts" /id="U1367" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.404595404595405" /psig=1 /xcortree=3145 /SigmaFactorBS="ccatctttgtttttgtaacacaactgtattataaaAATTGCC CtctcatttttttCTTGTTACAATAAAGCTATGccaaaacaaattgaccatgagaaaa g" /listShort="pksA" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1694233) /Source="Nicolas_upshifts" /id="U1368" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1400 /SigmaFactorBS="gcgccacgttgcttctgcaatttgttttcttcttttCTCATG gtcaatttgttttgGCATAGCTTTATTGTAACAagaaaaaaatgagagggcaattttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 1694234..1694371 /created_by="AR/SM" /note="N-terminus of previously known orfA is fused to a chromosomal 3`sequence resulting in an artificial C-terminal extension of the truncated protein A, transcription and translation is driven from known promoters and SD of orfA " /locus_tag="Delta6_BSU_17080-art" /modified_by="stephanmichalik" /transl_table=11 /pseudo /translation="MPKQIDHEKRRKQIAEATWRVILERGMEGASARNIAKEAGLSLE A*" /label="Delta6_BSU_17080-art" gene 1694234..1694371 /created_by="AR/SM" /note="N-terminus of previously known orfA is fused to a chromosomal 3`sequence resulting in an artificial C-terminal extension of the truncated protein A, transcription and translation is driven from known promoters and SD of orfA " /locus_tag="Delta6_BSU_17080-art" /label="Delta6_BSU_17080-art" promotor_-35 complement(1694252..1694257) /Source="Nicolas_upshift_promotors" /id="U1368" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1400 /SigmaFactorBS="gcgccacgttgcttctgcaatttgttttcttcttttCTCATG gtcaatttgttttgGCATAGCTTTATTGTAACAagaaaaaaatgagagggcaattttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" SCAR join(1694349,1695412) /created_by="User" /modified_by="User" /label="Delta5" N_region 1694350..1695411 /note="insertion of sequence with unknown origin - insert contains an independent promoter SD and chloramphenicol resistance gene" /created_by="User" /label="Delta5" promotor_-35 1694365..1694372 /Source="Nicolas_upshift_promotors" /id="U1370" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.914085914085914" /psig="0.993006993006993" /xcortree=556 /SigmaFactorBS="gcagaaaaacaatggagcaaactgtaggaaaaattAACTTGA CggataatatttacaGAGGTTACCATCAACATGAAcatgctactatttatccggtcat c" /listShort="S616, pksC, S617, pksD, pksE, acpK, pksF, pksG, pksH, pksI, pksJ, pksL, pksM, pksN, pksR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1694568..1694573 /created_by="User" /label="Delta5_SigA_-35" promotor_-10 1694591..1694596 /created_by="User" /label="Delta5_SigA_-10" upshifts complement(1694630) /Source="Nicolas_upshifts" /id="U1371" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1370 /SigmaFactorBS="ttcttaaggctgtttctatctatctttccgttcgGAGTTAAC GGcatatgatcaagcTGAATAAAATAAGAAGGCACcatataggcaggcaaagcgtttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 1694660..1695379 /gene="catA" /locus_tag="A8O17_RS08865" /old_locus_tag="A8O17_08865" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_032488880.1" /note="frameshifted; Derived by automated computational analysis using gene prediction method: Protein Homology." /pseudo /codon_start=1 /transl_table=11 /product="type A chloramphenicol O-acetyltransferase" /modified_by="User" /translation="MNFNKIDLDNWKRKEIFNHYLNQQTTFSITTEIDISVLYRNIKQ EGYKFYPAFIFLVTRVINSNTAFRTGYNSDGELGYWDKLEPLYTIFDGVSKTFSGIWT PVKNDFKEFYDLYLSDVEKYNGSGKLFPKTPIPENAFSLSIIPWTSFTGFNLNINNNS NYLLPIITAGKFINKGNSIYLPLSLQVHHSVCDGYHAGLFMNSIQELSDRPNDWLL*Y EIMPTVLFTVGFLMSLTCPVS*" /label="Delta6_NEW_001" gene 1694660..1695379 /gene="catA" /locus_tag="A8O17_RS08865" /old_locus_tag="A8O17_08865" /pseudo /modified_by="User" /label="Delta6_NEW_001" CDS 1695412..1695894 /note="pseudogene - residual C-terminal sequence due to internal deletion scar" /created_by="AR/SM" /locus_tag="Delta6_pseudo_BSU_17220" /modified_by="stephanmichalik" /transl_table=11 /pseudo /translation="EFLSELIDLAKERGLNKPDKQIRAQAQQMMKTQRAYDLESYTVK PLPDPETVKCYYFRNKSRSFFGDLDTYFTLSNEKEPFDQAAYWEEWERQIPHFHLVDV DSSNHFMILTEPKASTALLEFCEKLYSNRGVVNANFLKAFRKKHEAREEKETDELVKR *" /label="Delta6_pseudo_BSU_17220" gene 1695412..1695894 /note="pseudogene - residual C-terminal sequence due to internal deletion scar " /created_by="AR/SM" /modified_by="User" /locus_tag="Delta6_pseudo_BSU_17220" /label="Delta6_pseudo_BSU_17220" downshifts 1695883 /Source="Nicolas_upshifts" /id="D927" /incds=0 /nref=65 /ntot=216 /MaxReadThrough="0.92789" /MaxDrop="5.77685" /score="4.87908333" /energy="-14.6" /TU="NA" /idTUdmin="U1370" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(1695939..1697156) /gene="pksS" /locus_tag="BSU_17230" /old_locus_tag="BSU17230" /function="16.5: Explore" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 17482575, 16707694, 17234808, 17886826, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome P450 of bacillaene metabolism" /protein_id="NP_389605.2" /db_xref="EnsemblGenomes-Gn:BSU17230" /db_xref="EnsemblGenomes-Tr:CAB13607" /db_xref="GOA:O31785" /db_xref="InterPro:IPR001128" /db_xref="InterPro:IPR002397" /db_xref="InterPro:IPR017972" /db_xref="InterPro:IPR036396" /db_xref="PDB:4YZR" /db_xref="SubtiList:BG12655" /db_xref="UniProtKB/Swiss-Prot:O31785" /translation="MEKLMFHPHGKEFHHNPFSVLGRFREEEPIHRFELKRFGATYPA WLITRYDDCMAFLKDNRITRDVKNVMNQEQIKMLNVSEDIDFVSDHMLAKDTPDHTRL RSLVHQAFTPRTIENLRGSIEQIAEQLLDEMEKENKADIMKSFASPLPFIVISELMGI PKEDRSQFQIWTNAMVDTSEGNRELTNQALREFKDYIAKLIHDRRIKPKDDLISKLVH AEENGSKLSEKELYSMLFLLVVAGLETTVNLLGSGTLALLQHKKECEKLKQQPEMIAT AVEELLRYTSPVVMMANRWAIEDFTYKGHSIKRGDMIFIGIGSANRDPNFFENPEILN INRSPNRHISFGFGIHFCLGAPLARLEGHIAFKALLKRFPDIELAVAPDDIQWRKNVF LRGLESLPVSLSK*" /label="pksS CDS" gene complement(1695939..1697156) /gene="pksS" /locus_tag="BSU_17230" /old_locus_tag="BSU17230" /label="pksS gene" downshifts complement(1695958) /Source="Nicolas_upshifts" /id="D928" /incds=0 /nref=123 /ntot=225 /MaxReadThrough="0.911470000000001" /MaxDrop="4.23567" /score="16.9796453" /energy="-16.8" /TU="NA" /idTUdmin="U1373" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_no_box complement(1697171..1697271) /Source="Nicolas_upshift_promotors" /id="U1372" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.53046953046953" /psig="0.297702297702298" /xcortree=1727 /SigmaFactorBS="ctaagatagatatatagttttagagacaggattacatttcaa atcattctgttttttgtaaactaattcagcaatttgattcatctatttaccctattag g" /listShort="pksS" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1697211) /Source="Nicolas_upshifts" /id="U1372" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.53046953046953" /psig="0.297702297702298" /xcortree=1727 /SigmaFactorBS="ctaagatagatatatagttttagagacaggattacatttcaa atcattctgttttttgtaaactaattcagcaatttgattcatctatttaccctattag g" /listShort="pksS" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1697243..1697262) /Source="Nicolas_upshift_promotors" /id="U1373" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.85014985014985" /psig="0.999000999001" /xcortree=3215 /SigmaFactorBS="gccgttttttcacttttttcgttcttctcccTATTGAATgac gcctaagatagATATATAGTTTTAGAGACAGgattacatttcaaatcattctgttttt t" /listShort="pksS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1697255) /Source="Nicolas_upshifts" /id="U1373" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.85014985014985" /psig="0.999000999001" /xcortree=3215 /SigmaFactorBS="gccgttttttcacttttttcgttcttctcccTATTGAATgac gcctaagatagATATATAGTTTTAGAGACAGgattacatttcaaatcattctgttttt t" /listShort="pksS" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1697257..1697337) /Source="Nicolas_S_feature" /locus_tag="new_1859884_1859964_c" /HighExp="Salt, Etha, T-3.40H, T-0.40H, T-1.40H, LoTm, T-2.40H, S1, SMM, T-4.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.122" /TUlongSig="NA" /TUlongPSig="NA" /label="S618" promotor_-35 complement(1697277..1697284) /Source="Nicolas_upshift_promotors" /id="U1373" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.85014985014985" /psig="0.999000999001" /xcortree=3215 /SigmaFactorBS="gccgttttttcacttttttcgttcttctcccTATTGAATgac gcctaagatagATATATAGTTTTAGAGACAGgattacatttcaaatcattctgttttt t" /listShort="pksS" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(1697381) /Source="Nicolas_upshifts" /id="D929" /incds=0 /nref=24 /ntot=184 /MaxReadThrough="3.69744" /MaxDrop="5.18486" /score="-0.71313204" /energy="-20.1" /TU="U1374" /idTUdmin="U1375" /TUdmin=28 /isTUend="FALSE" /label="downshifts" CDS complement(1697387..1697743) /gene="ymzB" /locus_tag="BSU_17240" /old_locus_tag="BSU17240" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11544224, 15805528, 20817675" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function involved in ethanol resistance" /protein_id="NP_389606.3" /db_xref="EnsemblGenomes-Gn:BSU17240" /db_xref="EnsemblGenomes-Tr:CAB13608" /db_xref="SubtiList:BG13435" /db_xref="UniProtKB/Swiss-Prot:O31786" /translation="MAHTNTQLSQWLESKVGQTLDIRKGELTHDEEISDLDQIVLHLQ KVAIRSTNHPDDYVAKEELVLEGEGTTFTEDGNVPLPQNAYEIPLLGELHIHQENEGL KVVTDRAVYTIDIQHS*" /label="ymzB CDS" gene complement(1697387..1697743) /gene="ymzB" /locus_tag="BSU_17240" /old_locus_tag="BSU17240" /label="ymzB gene" misc_feature complement(1697803..1697816) /Source="Nicolas_upshift_promotors" /id="U1374" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.511488511488511" /psig="0.121878121878122" /xcortree=731 /SigmaFactorBS="ccgtacgctatatcaaggcactcaacagcgaactgtttcata cataaagagtGGGGCGGCTCTTTCccgtgtaaaagatgcagcaattgggaatagtatc g" /listShort="ymzB, S618, pksS" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1697808) /Source="Nicolas_upshifts" /id="U1374" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.511488511488511" /psig="0.121878121878122" /xcortree=731 /SigmaFactorBS="ccgtacgctatatcaaggcactcaacagcgaactgtttcata cataaagagtGGGGCGGCTCTTTCccgtgtaaaagatgcagcaattgggaatagtatc g" /listShort="ymzB, S618, pksS" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1697822..1698646) /gene="ymaE" /locus_tag="BSU_17250" /old_locus_tag="BSU17250" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20817675; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_389607.2" /db_xref="EnsemblGenomes-Gn:BSU17250" /db_xref="EnsemblGenomes-Tr:CAB13609" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG13413" /db_xref="UniProtKB/Swiss-Prot:O31787" /translation="MPYYICNTCGVQHAQTVDPPNSCLICEDERQYIHPDGQTWTTLE DMREKGNLQNILKKEEEHLYSIKTEPEFAIGQTAHLIQHKGFNVLWDCMTYLDQKTID QINELGGIQAIALSHPHYYSTQVEWAEAFQAPIYIHEDDKEWVTRPSNHIHFWSGETL NMKPGLDLYRLGGHFKGGAVLHWSKGNEGKGCLLTGDIITVAADRNWVSFMYSYPNLI PLPASKVEEIAAKVKPLQFNRLYNAFSKVVKENADESVQRSAVRYIKALNSELFHT*" /label="ymaE CDS" gene complement(1697822..1698646) /gene="ymaE" /locus_tag="BSU_17250" /old_locus_tag="BSU17250" /label="ymaE gene" promotor_-10 complement(1698668..1698687) /Source="Nicolas_upshift_promotors" /id="U1375" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.88011988011988" /psig="0.992007992007992" /xcortree=2946 /SigmaFactorBS="gccggcaattctctctcagcagaactgccggttttttcgTTT GAATattcataatcaTAAGGTAAAATAATGGAAAAtagatgaaggaagtgaagaaagt g" /listShort="ymaE, ymzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1698684) /Source="Nicolas_upshifts" /id="U1375" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.88011988011988" /psig="0.992007992007992" /xcortree=2946 /SigmaFactorBS="gccggcaattctctctcagcagaactgccggttttttcgTTT GAATattcataatcaTAAGGTAAAATAATGGAAAAtagatgaaggaagtgaagaaagt g" /listShort="ymaE, ymzB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1698699..1698705) /Source="Nicolas_upshift_promotors" /id="U1375" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.88011988011988" /psig="0.992007992007992" /xcortree=2946 /SigmaFactorBS="gccggcaattctctctcagcagaactgccggttttttcgTTT GAATattcataatcaTAAGGTAAAATAATGGAAAAtagatgaaggaagtgaagaaagt g" /listShort="ymaE, ymzB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1698757..1700085) /gene="aprX" /locus_tag="BSU_17260" /old_locus_tag="BSU17260" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10589719, 16267290, 17884659, 28693413" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10589719, 16267290, 17884659, 28693413; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alkaline serine protease" /protein_id="NP_389608.1" /db_xref="EnsemblGenomes-Gn:BSU17260" /db_xref="EnsemblGenomes-Tr:CAB13610" /db_xref="GOA:O31788" /db_xref="InterPro:IPR000209" /db_xref="InterPro:IPR015500" /db_xref="InterPro:IPR022398" /db_xref="InterPro:IPR023827" /db_xref="InterPro:IPR023828" /db_xref="InterPro:IPR036852" /db_xref="SubtiList:BG12567" /db_xref="UniProtKB/Swiss-Prot:O31788" /translation="MFGYSMVQMVRANAHKLDWPLRETVLQLYKPFKWTPCFLHKFFE TKLQNRKKMSVIIEFEEGCHETGFQMAGEVLQKEKRSKLKSRFNKINCCSAEVTPSAL HSLLSECSNIRKVYLNREVKALLDTATEASHAKEVVRNGQTLTGKGVTVAVVDTGIYP HPDLEGRIIGFADMVNQKTEPYDDNGHGTHCAGDVASSGASSSGQYRGPAPEANLIGV KVLNKQGSGTLADIIEGVEWCIQYNEDNPDEPIDIMSMSLGGDALRYDHEQEDPLVRA VEEAWSAGIVVCVAAGNSGPDSQTIASPGVSEKVITVGALDDNNTASSDDDTVASFSS RGPTVYGKEKPDILAPGVNIISLRSPNSYIDKLQKSSRVGSQYFTMSGTSMATPICAG IAALILQQNPDLTPDEVKELLKNGTDKWKDEDPNIYGAGAVNAENSVPGQ*" /label="aprX CDS" gene complement(1698757..1700085) /gene="aprX" /locus_tag="BSU_17260" /old_locus_tag="BSU17260" /label="aprX gene" downshifts complement(1698764) /Source="Nicolas_upshifts" /id="D930" /incds=0 /nref=13 /ntot=21 /MaxReadThrough="2.43809" /MaxDrop="5.8915" /score="10.5332562" /energy="-13" /TU="NA" /idTUdmin="U1376" /TUdmin=8 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1700108..1700127) /Source="Nicolas_upshift_promotors" /id="U1376" /multdbtbs="SigA" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1433 /SigmaFactorBS="aaaacaaactcttgtctgtctcttacagaggacaaacaAACT TACCAaacctatcatctgTTCATAGAGTATACAGAGAAccttataataggaggaaaat a" /listShort="aprX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1700127) /Source="Nicolas_upshifts" /id="U1376" /multdbtbs="SigA" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1433 /SigmaFactorBS="aaaacaaactcttgtctgtctcttacagaggacaaacaAACT TACCAaacctatcatctgTTCATAGAGTATACAGAGAAccttataataggaggaaaat a" /listShort="aprX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1700141..1700149) /Source="Nicolas_upshift_promotors" /id="U1376" /multdbtbs="SigA" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1433 /SigmaFactorBS="aaaacaaactcttgtctgtctcttacagaggacaaacaAACT TACCAaacctatcatctgTTCATAGAGTATACAGAGAAccttataataggaggaaaat a" /listShort="aprX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1700242..1700249 /Source="Nicolas_upshift_promotors" /id="U1378" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.806193806193806" /psig="0.999000999001" /xcortree=1507 /SigmaFactorBS="gatagattcagaagctgaggaaatcattgggGATTGAAAaag aacgtttgttcgTATTATAATGTGATCATATCaaactgggaaggggagagcaaccgta t" /listShort="ymzE, ymzE, S619, ymaC, ymaD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1700257..1700276) /Source="Nicolas_upshift_promotors" /id="U1377" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.753246753246753" /psig="0.999000999001" /xcortree=1500 /SigmaFactorBS="ggtgcaagtagaaattcatacggttgctctccCCTTCCCAgt ttgatatgatCACATTATAATACGAACAAAcgttctttttcaatccccaatgatttcc t" /listShort="aprX" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 1700265..1700284 /Source="Nicolas_upshift_promotors" /id="U1378" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.806193806193806" /psig="0.999000999001" /xcortree=1507 /SigmaFactorBS="gatagattcagaagctgaggaaatcattgggGATTGAAAaag aacgtttgttcgTATTATAATGTGATCATATCaaactgggaaggggagagcaaccgta t" /listShort="ymzE, ymzE, S619, ymaC, ymaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1700268) /Source="Nicolas_upshifts" /id="U1377" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.753246753246753" /psig="0.999000999001" /xcortree=1500 /SigmaFactorBS="ggtgcaagtagaaattcatacggttgctctccCCTTCCCAgt ttgatatgatCACATTATAATACGAACAAAcgttctttttcaatccccaatgatttcc t" /listShort="aprX" /GFF_Attribute="listLong" /label="upshifts" upshifts 1700271 /Source="Nicolas_upshifts" /id="U1378" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.806193806193806" /psig="0.999000999001" /xcortree=1507 /SigmaFactorBS="gatagattcagaagctgaggaaatcattgggGATTGAAAaag aacgtttgttcgTATTATAATGTGATCATATCaaactgggaaggggagagcaaccgta t" /listShort="ymzE, ymzE, S619, ymaC, ymaD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1700289..1700296) /Source="Nicolas_upshift_promotors" /id="U1377" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.753246753246753" /psig="0.999000999001" /xcortree=1500 /SigmaFactorBS="ggtgcaagtagaaattcatacggttgctctccCCTTCCCAgt ttgatatgatCACATTATAATACGAACAAAcgttctttttcaatccccaatgatttcc t" /listShort="aprX" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1700310..1700387 /gene="ymzEn" /locus_tag="BSU_17266" /old_locus_tag="BSU17266" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; N-terminal part of YmzE" /translation="MNFYLHRSLESQMPISIIYEERRND*" /label="ymzEn CDS" gene 1700310..1700387 /gene="ymzEn" /locus_tag="BSU_17266" /old_locus_tag="BSU17266" /pseudo /label="ymzEn gene" downshifts complement(1700312) /Source="Nicolas_upshifts" /id="D931" /incds=0 /nref=4 /ntot=7 /MaxReadThrough="1.51659" /MaxDrop="5.37668" /score="10.5332562" /energy="-13" /TU="NA" /idTUdmin="U1377" /TUdmin="-462" /isTUend="FALSE" /label="downshifts" CDS 1700365..1700541 /gene="ymzEc" /locus_tag="BSU_17267" /old_locus_tag="BSU17267" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; C-terminal part of YmzE" /db_xref="PSEUDO:CAX52622.1" /translation="MKKDGTISKRTIIVRQKSKTKIKAFCFSKQQIRTFLLDSILSCD FVRTNKQNLYSAGR*" /label="ymzEc CDS" gene 1700365..1700541 /gene="ymzEc" /locus_tag="BSU_17267" /old_locus_tag="BSU17267" /pseudo /label="ymzEc gene" downshifts 1700522 /Source="Nicolas_upshifts" /id="D932" /incds=0 /nref=42 /ntot=207 /MaxReadThrough="4.03151" /MaxDrop="6.55778" /score="-0.929304655" /energy="-5.5" /TU="U1378" /idTUdmin="U1378" /TUdmin="-1496" /isTUend="FALSE" /label="downshifts" S_feature 1700567..1700755 /Source="Nicolas_S_feature" /locus_tag="new_1863194_1863382" /HighExp="H2O2, M40t90, C90, M40t45, C30, S8, HiOs, G135, T-4.40H, T-5.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S619" misc_feature 1700750..1700769 /Source="Nicolas_upshift_promotors" /id="U1379" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.44955044955045" /psig=1 /xcortree=2371 /SigmaFactorBS="atcaattgattttttgaaaccgggaactttttcactgatgat attgtgtatacAATGGTAAGATAAAACCTATtggctaaacctcatataatgaaccgcg c" /listShort="ymaC, ymaD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1700757 /Source="Nicolas_upshifts" /id="U1379" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.44955044955045" /psig=1 /xcortree=2371 /SigmaFactorBS="atcaattgattttttgaaaccgggaactttttcactgatgat attgtgtatacAATGGTAAGATAAAACCTATtggctaaacctcatataatgaaccgcg c" /listShort="ymaC, ymaD" /GFF_Attribute="listLong" /label="upshifts" CDS 1700821..1701528 /gene="pghC" /locus_tag="BSU_17270" /old_locus_tag="BSU17270" /EC_number="3.4.19.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 16267290, 26158264; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="gamma-polyglutamate hydrolase (phage origin)" /protein_id="NP_389609.1" /db_xref="EnsemblGenomes-Gn:BSU17270" /db_xref="EnsemblGenomes-Tr:CAB13611" /db_xref="GOA:O31789" /db_xref="InterPro:IPR008585" /db_xref="SubtiList:BG13411" /db_xref="UniProtKB/Swiss-Prot:O31789" /translation="MRRFLLNVILVLAIVLFLRYVHYSLEPEPSNQPDTYSNFSSLAE NESPADYDISYNEKKGSKVLIMSPHGGRIEGGVSELVRYFNNEYSTYLFEGLKSHDNQ TLHITSTNFDEPLAKKKIKEHQYVVAFHGYKGENKNTLVGGTDRKRAKMIVRALERRG FSAELASSKSGLAGLNAENINNQGETGLSIQLEISREQREAFFDDFYYKNRKYTKNSE FYAYVSAIKGVLEKEYS*" /label="pghC CDS" gene 1700821..1701528 /gene="pghC" /locus_tag="BSU_17270" /old_locus_tag="BSU17270" /label="pghC gene" promotor_-35 1701539..1701545 /Source="Nicolas_upshift_promotors" /id="U1380" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.377622377622378" /psig="0.843156843156843" /xcortree=1826 /SigmaFactorBS="gtgtcctggaaaaagagtattcgtaacaagcagatcAGAAGA CaaaataagagaagATCAGTAGACTGAAATAGGAtaaaaaaggaggcaaaacaatggc a" /listShort="ymaD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1701559..1701578 /Source="Nicolas_upshift_promotors" /id="U1380" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.377622377622378" /psig="0.843156843156843" /xcortree=1826 /SigmaFactorBS="gtgtcctggaaaaagagtattcgtaacaagcagatcAGAAGA CaaaataagagaagATCAGTAGACTGAAATAGGAtaaaaaaggaggcaaaacaatggc a" /listShort="ymaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1701563 /Source="Nicolas_upshifts" /id="U1380" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.377622377622378" /psig="0.843156843156843" /xcortree=1826 /SigmaFactorBS="gtgtcctggaaaaagagtattcgtaacaagcagatcAGAAGA CaaaataagagaagATCAGTAGACTGAAATAGGAtaaaaaaggaggcaaaacaatggc a" /listShort="ymaD" /GFF_Attribute="listLong" /label="upshifts" CDS 1701598..1702050 /gene="ymaD" /locus_tag="BSU_17280" /old_locus_tag="BSU17280" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16267290, 22904090, 25649915; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative peroxiredoxin-related protein" /protein_id="NP_389610.1" /db_xref="EnsemblGenomes-Gn:BSU17280" /db_xref="EnsemblGenomes-Tr:CAB13612" /db_xref="InterPro:IPR003718" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR019905" /db_xref="InterPro:IPR036102" /db_xref="SubtiList:BG13412" /db_xref="UniProtKB/Swiss-Prot:O31790" /translation="MADHHFYLKANWPGNRNDVGTIESGNLITSISIPKEMDGPGEGT NPDEMLLGAAATCYIITLAAMMERSGLEKEDLQMESEGIVNVTKGVFTYKKIIHRPSV VLKHDASQDDVALAHKLCKKAESSCMISRAIQGNVELQLEASVKLGGE*" /label="ymaD CDS" gene 1701598..1702050 /gene="ymaD" /locus_tag="BSU_17280" /old_locus_tag="BSU17280" /label="ymaD gene" downshifts 1702038 /Source="Nicolas_upshifts" /id="D933" /incds=0 /nref=44 /ntot=182 /MaxReadThrough="1.35366" /MaxDrop="6.07534" /score="17.0193804" /energy="-12.1" /TU="NA" /idTUdmin="U1379" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(1702064..1702417) /gene="ebrB" /locus_tag="BSU_17290" /old_locus_tag="BSU17290" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10735876, 15849754, 16750162, 16850406, 18024586, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10735876, 15849754, 16750162, 16850406, 18024586, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="small toxic metabolite efflux transporter subunit" /protein_id="NP_389611.1" /db_xref="EnsemblGenomes-Gn:BSU17290" /db_xref="EnsemblGenomes-Tr:CAB13613" /db_xref="GOA:P0CW82" /db_xref="InterPro:IPR000390" /db_xref="SubtiList:BG12586" /db_xref="UniProtKB/Swiss-Prot:P0CW82" /translation="MRGLLYLALAIVSEVFGSTMLKLSEGFTQAWPIAGVIVGFLSAF TFLSFSLKTIDLSSAYATWSGVGTALTAIVGFLLFGETISLKGVFGLTLVIAGVVVLN QSKAHAEDKKQTACE*" /label="ebrB CDS" gene complement(1702064..1702417) /gene="ebrB" /locus_tag="BSU_17290" /old_locus_tag="BSU17290" /label="ebrB gene" downshifts complement(1702105) /Source="Nicolas_upshifts" /id="D934" /incds=0 /nref=2 /ntot=45 /MaxReadThrough="0.84905" /MaxDrop="2.87924" /score="-2.89884673" /energy="-8.7" /TU="NA" /idTUdmin="U1381" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" CDS complement(1702431..1702748) /gene="ebrA" /locus_tag="BSU_17300" /old_locus_tag="BSU17300" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10735876, 11104814, 17516673, 18024586" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10735876, 11104814, 17516673, 18024586; Product type t: transporter" /codon_start=1 /transl_table=11 /product="small toxic metabolite efflux transporter subunit" /protein_id="NP_389612.1" /db_xref="EnsemblGenomes-Gn:BSU17300" /db_xref="EnsemblGenomes-Tr:CAB13614" /db_xref="GOA:P0CW80" /db_xref="InterPro:IPR000390" /db_xref="SubtiList:BG12585" /db_xref="UniProtKB/Swiss-Prot:P0CW80" /translation="MLIGYIFLTIAICSESIGAAMLKVSDGFKKWKPSALVVIGYSLA FYMLSLTLNHIPLSLSYATWSGAGTVLTTVIGVKWFKEDLNAKGLIGILLLLSGVVLL NWP*" /label="ebrA CDS" gene complement(1702431..1702748) /gene="ebrA" /locus_tag="BSU_17300" /old_locus_tag="BSU17300" /label="ebrA gene" promotor_-10 complement(1702792..1702811) /Source="Nicolas_upshift_promotors" /id="U1381" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.843156843156843" /psig="0.998001998001998" /xcortree=1863 /SigmaFactorBS="gtctttttaagtgtgtgaaaatgaatcTCTTGACTcatacat aggcataCACTAATATTTTTCTAGCTGaagttttttttctaatctaaaaatatagtga g" /listShort="ebrA, ebrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1702800) /Source="Nicolas_upshifts" /id="U1381" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.843156843156843" /psig="0.998001998001998" /xcortree=1863 /SigmaFactorBS="gtctttttaagtgtgtgaaaatgaatcTCTTGACTcatacat aggcataCACTAATATTTTTCTAGCTGaagttttttttctaatctaaaaatatagtga g" /listShort="ebrA, ebrB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1702826..1702833) /Source="Nicolas_upshift_promotors" /id="U1381" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.843156843156843" /psig="0.998001998001998" /xcortree=1863 /SigmaFactorBS="gtctttttaagtgtgtgaaaatgaatcTCTTGACTcatacat aggcataCACTAATATTTTTCTAGCTGaagttttttttctaatctaaaaatatagtga g" /listShort="ebrA, ebrB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1702885..1703160) /gene="ymaG" /locus_tag="BSU_17310" /old_locus_tag="BSU17310" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 19775244, 19933362, 22882546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 19775244, 19933362, 22882546; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="inner spore coat protein; cell wall associated protein" /protein_id="NP_389613.2" /db_xref="EnsemblGenomes-Gn:BSU17310" /db_xref="EnsemblGenomes-Tr:CAB13615" /db_xref="GOA:O31793" /db_xref="SubtiList:BG13415" /db_xref="UniProtKB/Swiss-Prot:O31793" /translation="MNELEHFSPEDTRIFGRPFGFGRPFGFGRPFGFGYGFGRPGFGY GFGRPFGFFGGPFIGGLAGGLIGSALFNPYLYGGYPYYPYAPFPFYY*" /label="ymaG CDS" gene complement(1702885..1703160) /gene="ymaG" /locus_tag="BSU_17310" /old_locus_tag="BSU17310" /label="ymaG gene" downshifts complement(1702886) /Source="Nicolas_upshifts" /id="D935" /incds=0 /nref=38 /ntot=44 /MaxReadThrough="0.28059" /MaxDrop="8.33353" /score="12.3408391" /energy="-11.5" /TU="NA" /idTUdmin="U1383" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1703156..1703161 /Source="Nicolas_upshift_promotors" /id="U1382" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=1027 /SigmaFactorBS="gctgaaatgctctaactcgTTCATGttttctttcctcctgTA ATAAAGTGTAGATGATGcagtgtattcaccctgcccggatttgattgggcgaatcgag g" /listShort="ymaF, miaA, ymaH" /listLong="ymzC" /label="promotor_-35" promotor_-10 1703177..1703195 /Source="Nicolas_upshift_promotors" /id="U1382" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=1027 /SigmaFactorBS="gctgaaatgctctaactcgTTCATGttttctttcctcctgTA ATAAAGTGTAGATGATGcagtgtattcaccctgcccggatttgattgggcgaatcgag g" /listShort="ymaF, miaA, ymaH" /listLong="ymzC" /label="promotor_-10" promotor_-10 complement(1703187..1703206) /Source="Nicolas_upshift_promotors" /id="U1383" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1298 /SigmaFactorBS="caatgtgttcacatcctccttttcctcgattcGCCCAATCAA atccgggcagggTGAATACACTGCATCATCTAcactttattacaggaggaaagaaaac a" /listShort="ymaG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1703197 /Source="Nicolas_upshifts" /id="U1382" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=1027 /SigmaFactorBS="gctgaaatgctctaactcgTTCATGttttctttcctcctgTA ATAAAGTGTAGATGATGcagtgtattcaccctgcccggatttgattgggcgaatcgag g" /listShort="ymaF, miaA, ymaH" /listLong="ymzC" /label="upshifts" upshifts complement(1703200) /Source="Nicolas_upshifts" /id="U1383" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1298 /SigmaFactorBS="caatgtgttcacatcctccttttcctcgattcGCCCAATCAA atccgggcagggTGAATACACTGCATCATCTAcactttattacaggaggaaagaaaac a" /listShort="ymaG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1703219..1703228) /Source="Nicolas_upshift_promotors" /id="U1383" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1298 /SigmaFactorBS="caatgtgttcacatcctccttttcctcgattcGCCCAATCAA atccgggcagggTGAATACACTGCATCATCTAcactttattacaggaggaaagaaaac a" /listShort="ymaG" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1703249..1703662 /gene="ymaF" /locus_tag="BSU_17320" /old_locus_tag="BSU17320" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 24098137, 25915524" /codon_start=1 /transl_table=11 /product="putative sporulation-related protein of unknown function" /protein_id="NP_389614.2" /db_xref="EnsemblGenomes-Gn:BSU17320" /db_xref="EnsemblGenomes-Tr:CAB13616" /db_xref="InterPro:IPR024307" /db_xref="SubtiList:BG13414" /db_xref="UniProtKB/Swiss-Prot:O31794" /translation="MNTLGLYQSDWSKAPPHAHAYHVKTTREQGHYHLIEGFTQPANG SNTDQHTHYYTGITSFENGHFHRYYGISGPAIPLADGTHYHEIEETTYLAYNEPIEIQ YGGVVYDPGDDRRKTHRHTLKGKTREIVGNEPLGW*" /label="ymaF CDS" gene 1703249..1703662 /gene="ymaF" /locus_tag="BSU_17320" /old_locus_tag="BSU17320" /label="ymaF gene" upshifts 1703713 /Source="Nicolas_upshifts" /id="U1384" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.786213786213786" /psig="0.883116883116883" /xcortree=2366 /SigmaFactorBS="cggctggtagaaggatgtttaccgatgcaaaaaaagggcaaa atggataggtggttgtccatgttgAATGCTATAATGGGGGGAGAtttataaaagagag t" /listShort="miaA, ymaH" /listLong="ymzC, ymzA, S620, S621, nrdI, nrdE, nrdF, ymaB" /label="upshifts" misc_feature 1703719..1703738 /Source="Nicolas_upshift_promotors" /id="U1384" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.786213786213786" /psig="0.883116883116883" /xcortree=2366 /SigmaFactorBS="cggctggtagaaggatgtttaccgatgcaaaaaaagggcaaa atggataggtggttgtccatgttgAATGCTATAATGGGGGGAGAtttataaaagagag t" /listShort="miaA, ymaH" /listLong="ymzC, ymzA, S620, S621, nrdI, nrdE, nrdF, ymaB" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 1703762..1704706 /gene="miaA" /locus_tag="BSU_17330" /old_locus_tag="BSU17330" /EC_number="2.5.1.75" /function="16.3: Control" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 3045085, 11160115, 26735940, 28277934, 28471404; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA isopentenylpyrophosphate transferase" /protein_id="NP_389615.2" /db_xref="EnsemblGenomes-Gn:BSU17330" /db_xref="EnsemblGenomes-Tr:CAB13617" /db_xref="GOA:O31795" /db_xref="InterPro:IPR018022" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12617" /db_xref="UniProtKB/Swiss-Prot:O31795" /translation="MNNTKQPVVILVGPTAVGKTNLSIQLAKSLNAEIISGDSMQIYK GMDIGTAKITEQEMEGVPHHLIDILDPQDSFSTADYQSLVRNKISEIANRGKLPMIVG GTGLYIQSVLYDYTFTEEANDPVFRESMQMAAEREGADFLHAKLAAADPEAAAAIHPN NTRRVIRALEILHTSGKTMSQHLKEQKRELLYNAVLIGLTMDRDTLYERINQRVDLMM QSGLLPEVKRLYDKNVRDCQSIQAIGYKELYAYFDGFVTLSDAVEQLKQNSRRYAKRQ LTWFRNKMQVTWFDMTPPVDMELKKKEIFTHIAGKLEL*" /label="miaA CDS" gene 1703762..1704706 /gene="miaA" /locus_tag="BSU_17330" /old_locus_tag="BSU17330" /label="miaA gene" promotor_-35 1704686..1704694 /Source="Nicolas_upshift_promotors" /id="U1385" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=547 /SigmaFactorBS="gatatggagctgaaaaaaaaggaaattttcacacatataGCA GGAAAActcgaactttAATCGAAACTGTATGATATagagaatcaaggaggacgaaaca t" /listShort="ymaH, ymzC, ymzA, S620, S621" /listLong="nrdI, nrdE, nrdF, ymaB" /label="promotor_-35" promotor_-10 1704705..1704723 /Source="Nicolas_upshift_promotors" /id="U1385" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=547 /SigmaFactorBS="gatatggagctgaaaaaaaaggaaattttcacacatataGCA GGAAAActcgaactttAATCGAAACTGTATGATATagagaatcaaggaggacgaaaca t" /listShort="ymaH, ymzC, ymzA, S620, S621" /listLong="nrdI, nrdE, nrdF, ymaB" /label="promotor_-10" upshifts 1704707 /Source="Nicolas_upshifts" /id="U1385" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=547 /SigmaFactorBS="gatatggagctgaaaaaaaaggaaattttcacacatataGCA GGAAAActcgaactttAATCGAAACTGTATGATATagagaatcaaggaggacgaaaca t" /listShort="ymaH, ymzC, ymzA, S620, S621" /listLong="nrdI, nrdE, nrdF, ymaB" /label="upshifts" CDS 1704746..1704967 /gene="hfq" /locus_tag="BSU_17340" /old_locus_tag="BSU17340" /function="16.3: Control" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16166525, 20445260, 22053080, 23457461, 24932523, 27049793, 27581927" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16166525, 20445260, 22053080, 23457461, 24932523, 27049793, 27581927; Product type f: factor" /codon_start=1 /transl_table=11 /product="Hfq RNA chaperone" /protein_id="NP_389616.1" /db_xref="EnsemblGenomes-Gn:BSU17340" /db_xref="EnsemblGenomes-Tr:CAB13618" /db_xref="GOA:O31796" /db_xref="InterPro:IPR005001" /db_xref="InterPro:IPR010920" /db_xref="PDB:3AHU" /db_xref="PDB:3HSB" /db_xref="SubtiList:BG13416" /db_xref="UniProtKB/Swiss-Prot:O31796" /translation="MKPINIQDQFLNQIRKENTYVTVFLLNGFQLRGQVKGFDNFTVL LESEGKQQLIYKHAISTFAPQKNVQLELE*" /label="hfq CDS" gene 1704746..1704967 /gene="hfq" /locus_tag="BSU_17340" /old_locus_tag="BSU17340" /label="hfq gene" downshifts complement(1704757) /Source="Nicolas_upshifts" /id="D936" /incds=0 /nref=3 /ntot=108 /MaxReadThrough="1.19472" /MaxDrop="3.56162" /score="-5.83707008" /energy="-5.2" /TU="NA" /idTUdmin="U1386" /TUdmin=22 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1704819..1704823) /Source="Nicolas_upshift_promotors" /id="U1386" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.998001998001998" /psig="0.000999000999001" /xcortree=46 /SigmaFactorBS="ttccaacaatacggtaaagttatcaaagcctttcacctggCC CCGCaactgaaagccgttCAGCAaaaaaacagtgacatacgtattttctttccggatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1704823) /Source="Nicolas_upshifts" /id="U1386" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.998001998001998" /psig="0.000999000999001" /xcortree=46 /SigmaFactorBS="ttccaacaatacggtaaagttatcaaagcctttcacctggCC CCGCaactgaaagccgttCAGCAaaaaaacagtgacatacgtattttctttccggatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1704838..1704843) /Source="Nicolas_upshift_promotors" /id="U1386" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.998001998001998" /psig="0.000999000999001" /xcortree=46 /SigmaFactorBS="ttccaacaatacggtaaagttatcaaagcctttcacctggCC CCGCaactgaaagccgttCAGCAaaaaaacagtgacatacgtattttctttccggatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1704967 /Source="Nicolas_upshifts" /id="D937" /incds=0 /nref=26 /ntot=212 /MaxReadThrough="5.10866" /MaxDrop="4.06475" /score="17.2354231" /energy="-17" /TU="U1382,U1385" /idTUdmin="U1384" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 1705163..1705435 /gene="ymzC" /locus_tag="BSU_17350" /old_locus_tag="BSU17350" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389617.1" /db_xref="EnsemblGenomes-Gn:BSU17350" /db_xref="EnsemblGenomes-Tr:CAB13619" /db_xref="InterPro:IPR025448" /db_xref="PDB:3KVP" /db_xref="SubtiList:BG13436" /db_xref="UniProtKB/Swiss-Prot:O31797" /translation="MFESEAELRRIRIALVWIAVFLLFGACGNQDTIIETDNGNSDYE TPQPTSFPLEHNHFGVMEDGYIKIYEYNESRNEVKLKKEYADDELE*" /label="ymzC CDS" gene 1705163..1705435 /gene="ymzC" /locus_tag="BSU_17350" /old_locus_tag="BSU17350" /label="ymzC gene" promotor_-35 1705451..1705458 /Source="Nicolas_upshift_promotors" /id="U1387" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.84015984015984" /psig=1 /xcortree=2039 /SigmaFactorBS="cgcggatgatgagcttgaataaaattcacaagcattcGAATT TACaaagcggatgccaGCCGCTAAACTAAATACAGAcacagatcaaacagagggtgaa a" /listShort="ymzA, S620, S621, nrdI, nrdE, nrdF, ymaB, S623" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1705472..1705491 /Source="Nicolas_upshift_promotors" /id="U1387" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.84015984015984" /psig=1 /xcortree=2039 /SigmaFactorBS="cgcggatgatgagcttgaataaaattcacaagcattcGAATT TACaaagcggatgccaGCCGCTAAACTAAATACAGAcacagatcaaacagagggtgaa a" /listShort="ymzA, S620, S621, nrdI, nrdE, nrdF, ymaB, S623" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1705474 /Source="Nicolas_upshifts" /id="U1387" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.84015984015984" /psig=1 /xcortree=2039 /SigmaFactorBS="cgcggatgatgagcttgaataaaattcacaagcattcGAATT TACaaagcggatgccaGCCGCTAAACTAAATACAGAcacagatcaaacagagggtgaa a" /listShort="ymzA, S620, S621, nrdI, nrdE, nrdF, ymaB, S623" /GFF_Attribute="listLong" /label="upshifts" CDS 1705517..1705747 /gene="ymzA" /locus_tag="BSU_17360" /old_locus_tag="BSU17360" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389618.1" /db_xref="EnsemblGenomes-Gn:BSU17360" /db_xref="EnsemblGenomes-Tr:CAB13620" /db_xref="SubtiList:BG13434" /db_xref="UniProtKB/Swiss-Prot:O31798" /translation="MKHKVIVNHWEEICEDDSCYEYGTSIIVNGKELIREASIITALK AVLEEIGADVEIEETVESEKCCDSLRKKNLDY*" /label="ymzA CDS" gene 1705517..1705747 /gene="ymzA" /locus_tag="BSU_17360" /old_locus_tag="BSU17360" /label="ymzA gene" S_feature 1705748..1705824 /Source="Nicolas_S_feature" /locus_tag="new_1868375_1868451" /HighExp="dia5, dia15, Diami, B60, G150, H2O2, LPhT, G180, G135, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH" /TUshortPSig="1, 0.999" /TUlongSig="SigA" /TUlongPSig="0.883" /label="S620" downshifts 1705781 /Source="Nicolas_upshifts" /id="D938" /incds=0 /nref=24 /ntot=61 /MaxReadThrough="7.47169" /MaxDrop="4.19691" /score="8.2587309" /energy="-16.9" /TU="U1385,U1387" /idTUdmin="U1385" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" S_feature 1705826..1705933 /Source="Nicolas_S_feature" /locus_tag="new_1868453_1868560" /HighExp="G180, G150, G135, H2O2, dia15, Paraq, LBGexp, C30, Diami, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH" /TUshortPSig="1, 0.999" /TUlongSig="SigA" /TUlongPSig="0.883" /label="S621" promotor_-35 1705906..1705913 /Source="Nicolas_upshift_promotors" /id="U1388" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.653346653346653" /psig=1 /xcortree=3005 /SigmaFactorBS="aatatgaatttttcataaaaacgaatctataTATTGTGTttt tgctagagggTAGTATACTATATATAGTGTtagtgatgagagattcatattttttgat a" /listShort="nrdI, nrdE, nrdF, ymaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1705927..1705946 /Source="Nicolas_upshift_promotors" /id="U1388" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.653346653346653" /psig=1 /xcortree=3005 /SigmaFactorBS="aatatgaatttttcataaaaacgaatctataTATTGTGTttt tgctagagggTAGTATACTATATATAGTGTtagtgatgagagattcatattttttgat a" /listShort="nrdI, nrdE, nrdF, ymaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1705935 /Source="Nicolas_upshifts" /id="U1388" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.653346653346653" /psig=1 /xcortree=3005 /SigmaFactorBS="aatatgaatttttcataaaaacgaatctataTATTGTGTttt tgctagagggTAGTATACTATATATAGTGTtagtgatgagagattcatattttttgat a" /listShort="nrdI, nrdE, nrdF, ymaB" /GFF_Attribute="listLong" /label="upshifts" CDS 1705990..1706382 /gene="nrdI" /locus_tag="BSU_17370" /old_locus_tag="BSU17370" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 16885274, 21561096, 22443445, 23402532, 26507228" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16885274, 21561096, 22443445, 23402532, 26507228; Product type f : factor" /codon_start=1 /transl_table=11 /product="co-factor of ribonucleotide diphosphate reductase" /protein_id="NP_389619.1" /db_xref="EnsemblGenomes-Gn:BSU17370" /db_xref="EnsemblGenomes-Tr:CAB13621" /db_xref="GOA:P50618" /db_xref="InterPro:IPR004465" /db_xref="InterPro:IPR020852" /db_xref="InterPro:IPR029039" /db_xref="PDB:1RLJ" /db_xref="SubtiList:BG11426" /db_xref="UniProtKB/Swiss-Prot:P50618" /translation="MVQIIFDSKTGNVQRFVNKTGFQQIRKVDEMDHVDTPFVLVTYT TNFGQVPASTQSFLEKYAHLLLGVAASGNKVWGDNFAKSADTISRQYQVPILHKFELS GTSKDVELFTQEVERVVTKSSAKMDPVK*" /label="nrdI CDS" gene 1705990..1706382 /gene="nrdI" /locus_tag="BSU_17370" /old_locus_tag="BSU17370" /label="nrdI gene" CDS 1706342..1708444 /gene="nrdE" /locus_tag="BSU_17380" /old_locus_tag="BSU17380" /EC_number="1.17.4.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15937154, 16885274, 17395719, 21561096, 22443445, 23402532, 24401092, 27920297" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15937154, 16885274, 17395719, 21561096, 22443445, 23402532, 24401092, 27920297; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonucleoside-diphosphate reductase (major subunit)" /protein_id="NP_389620.1" /db_xref="EnsemblGenomes-Gn:BSU17380" /db_xref="EnsemblGenomes-Tr:CAB13622" /db_xref="GOA:P50620" /db_xref="InterPro:IPR000788" /db_xref="InterPro:IPR008926" /db_xref="InterPro:IPR013346" /db_xref="InterPro:IPR013509" /db_xref="InterPro:IPR013554" /db_xref="InterPro:IPR026459" /db_xref="SubtiList:BG11404" /db_xref="UniProtKB/Swiss-Prot:P50620" /translation="MSQNQVPKWIQLNNEIMIQKDGKFQFDKDKEAVHSYFVDYINQN TVFFHNLKEKLDYLVENQYYEEEFLSLYSFEDIKEVFKTAYAKKFRFPSFMSAFKFYN DYALKTNDKKKILERYEDRISIVALFFANGDTEKAKEYVNLMINQEYQPSTPTFLNAG RKRRGELVSCFLLEVNDSLNDISRAIDISMQLSKLGGGVSLNLSKLRAKGEAIKDVEN ATKGVVGVMKLLDNAFRYADQMGQRQGSGAAYLNIFHRDINDFLDTKKISADEDVRVK TLSIGVVIPDKFVELAREDKAAYVFYPHTIYKEYGQHMDEMDMNEMYDKFVDNPRVKK EKINPRKLLEKLAMLRSESGYPYIMFQDNVNKVHANNHISKVKFSNLCSEVLQASQVS SYTDYDEEDEIGLDISCNLGSLNILNVMEHKSIEKTVKLATDSLTHVSETTDIRNAPA VRRANKAMKSIGLGAMNLHGYLAQNGIAYESPEARDFANTFFMMVNFYSIQRSAEIAK EKGETFDQYEGSTYATGEYFDKYVSTDFSPKYEKIANLFEGMHIPTTEDWKKLKAFVA EHGMYHSYRLCIAPTGSISYVQSSTASVMPIMERIEERTYGNSKTYYPMPGLASNNWF FYKEAYDMDMFKVVDMIATIQQHIDQGISFTLFLKDTMTTRDLNRIDLYAHHRGIKTI YYARTKDTGQDSCLSCVV*" /label="nrdE CDS" gene 1706342..1708444 /gene="nrdE" /locus_tag="BSU_17380" /old_locus_tag="BSU17380" /label="nrdE gene" CDS 1708462..1709451 /gene="nrdF" /locus_tag="BSU_17390" /old_locus_tag="BSU17390" /EC_number="1.17.4.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15937154, 16885274, 17395719, 21561096, 22443445, 23402532, 24401092, 27920297" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15937154, 16885274, 17395719, 21561096, 22443445, 23402532, 24401092, 27920297; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonucleoside-diphosphate reductase (minor subunit)" /protein_id="NP_389621.1" /db_xref="EnsemblGenomes-Gn:BSU17390" /db_xref="EnsemblGenomes-Tr:CAB13623" /db_xref="GOA:P50621" /db_xref="InterPro:IPR000358" /db_xref="InterPro:IPR009078" /db_xref="InterPro:IPR026494" /db_xref="InterPro:IPR030475" /db_xref="InterPro:IPR033909" /db_xref="PDB:4DR0" /db_xref="SubtiList:BG11405" /db_xref="UniProtKB/Swiss-Prot:P50621" /translation="MTKIYDAANWSKHEDDFTQMFYNQNVKQFWLPEEIALNGDLLTW KYLGKNEQDTYMKVLAGLTLLDTEQGNTGMPIVAEHVDGHQRKAVLNFMAMMENAVHA KSYSNIFMTLAPTETINEVFEWVKQNKYLQKKAQMIVGLYKAIQKDDEISLFKAMVAS VYLESFLFYSGFYYPLYFYGQGKLMQSGEIINLILRDEAIHGVYVGLLAQEIYNKQTE EKKAELREFAIDLLNQLYENELEYTEDLYDQVGLSHDVKKFIRYNANKALMNLGFDPY FEEEDINPIVLNGLNTKTKSHDFFSMKGNGYKKATVEPLKDDDFYFEDEKEQI*" /label="nrdF CDS" gene 1708462..1709451 /gene="nrdF" /locus_tag="BSU_17390" /old_locus_tag="BSU17390" /label="nrdF gene" downshifts 1709411 /Source="Nicolas_upshifts" /id="D939" /incds=0 /nref=3 /ntot=106 /MaxReadThrough="6.49299" /MaxDrop="2.8143" /score="-8.26008921" /energy="-10.8" /TU="U1387,U1388" /idTUdmin="U1388" /TUdmin="-726" /isTUend="FALSE" /label="downshifts" S_feature complement(1709465..1710124) /Source="Nicolas_S_feature" /locus_tag="new_1872092_1872751_c" /HighExp="BT, B36, C30, Pyr, S8, G135, G/S, Glucon, B60, C90" /AntisenseName="ymaB" /AntisenseCor="-0.136438199650502" /AntisenseRegPval="-1.6" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S622" downshifts complement(1709480) /Source="Nicolas_upshifts" /id="D940" /incds=0 /nref=3 /ntot=8 /MaxReadThrough="2.78803" /MaxDrop="4.0424" /score="6.77419677" /energy="-10.8" /TU="NA" /idTUdmin="U1390" /TUdmin=7 /isTUend="TRUE" /label="downshifts" CDS 1709501..1710121 /gene="ymaB" /locus_tag="BSU_17400" /old_locus_tag="BSU17400" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16885274, 21561096; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative cofactor involved in deoxyribonucleotide synthesis" /protein_id="NP_389622.1" /db_xref="EnsemblGenomes-Gn:BSU17400" /db_xref="EnsemblGenomes-Tr:CAB13624" /db_xref="GOA:P50619" /db_xref="InterPro:IPR015797" /db_xref="SubtiList:BG11427" /db_xref="UniProtKB/Swiss-Prot:P50619" /translation="MGKMDEMILVAPRDDVFKKESLTFQGVYSEDSRVAEIMAQIEAA YREMRRGDAEEDPRFKQPIPYVVIKREDEVFLYERLAGGGESRLHNKLSLGFGGHMNA IEGAASFAEVLKLNTDRELEEELQINEEDKQAIVTLGLINDDENSVGKVHIGILSALQ LKPGAQVEVKEKEQIAGKWMKVSELKQDDIYNRLETWSQFVVDILE*" /label="ymaB CDS" gene 1709501..1710121 /gene="ymaB" /locus_tag="BSU_17400" /old_locus_tag="BSU17400" /label="ymaB gene" downshifts 1710102 /Source="Nicolas_upshifts" /id="D941" /incds=0 /nref=130 /ntot=257 /MaxReadThrough="4.3301" /MaxDrop="6.0751" /score="31.3992458" /energy="-16.3" /TU="U1387,U1388" /idTUdmin="U1388" /TUdmin="-35" /isTUend="FALSE" /label="downshifts" promotor_-35 1710137..1710141 /Source="Nicolas_upshift_promotors" /id="U1389" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.631368631368631" /psig="0.230769230769231" /xcortree=1799 /SigmaFactorBS="ttgttgttgatattcttgaataaaaaaacccggtttctCGCG AtgaggagccgggtttttttatGAGACGCTCGTCCCCGTCtcggctatgattctagga t" /listShort="S623" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1710159..1710526 /Source="Nicolas_S_feature" /locus_tag="new_1872786_1873153" /HighExp="dia15, G180, H2O2, G135, G150, Diami, Paraq, Oxctl, LBGexp, C30" /AntisenseName="cwlC" /AntisenseCor="-8.9131707018362205E-2" /AntisenseRegPval="-0.8" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.231, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S623" upshifts 1710159 /Source="Nicolas_upshifts" /id="U1389" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.631368631368631" /psig="0.230769230769231" /xcortree=1799 /SigmaFactorBS="ttgttgttgatattcttgaataaaaaaacccggtttctCGCG AtgaggagccgggtttttttatGAGACGCTCGTCCCCGTCtcggctatgattctagga t" /listShort="S623" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1710163..1710180 /Source="Nicolas_upshift_promotors" /id="U1389" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.631368631368631" /psig="0.230769230769231" /xcortree=1799 /SigmaFactorBS="ttgttgttgatattcttgaataaaaaaacccggtttctCGCG AtgaggagccgggtttttttatGAGACGCTCGTCCCCGTCtcggctatgattctagga t" /listShort="S623" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(1710169) /Source="Nicolas_upshifts" /id="D942" /incds=0 /nref=1 /ntot=53 /MaxReadThrough="7.25519" /MaxDrop="4.6417" /score="9.14776993" /energy="-8.9" /TU="U1390" /idTUdmin="U1390" /TUdmin="-682" /isTUend="FALSE" /label="downshifts" CDS complement(1710185..1710952) /gene="cwlC" /locus_tag="BSU_17410" /old_locus_tag="BSU17410" /EC_number="3.5.1.28" /function="16.5: Explore" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10515909, 10945275, 10974124, 11375403, 16042392" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10515909, 10945275, 10974124, 11375403, 16042392; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylmuramoyl-L-alanine amidase (sporulation-specific)" /protein_id="NP_389623.2" /db_xref="EnsemblGenomes-Gn:BSU17410" /db_xref="EnsemblGenomes-Tr:CAB13625" /db_xref="GOA:Q06320" /db_xref="InterPro:IPR002508" /db_xref="InterPro:IPR007730" /db_xref="InterPro:IPR036680" /db_xref="PDB:1X60" /db_xref="SubtiList:BG10825" /db_xref="UniProtKB/Swiss-Prot:Q06320" /translation="MVKIFIDPGHGGSDPGATGNGLQEKTLTLQIALALRTILTNEYE GVSLLLSRTSDQYVSLNDRTNAANNWGADFFLSIHVNSGGGTGFESYIYPDVGAPTTT YQSTIHSEVIQAVDFADRGKKTANFHVLRESAMPALLTENGFIDTVSDANKLKTSSFI QSLARGHANGLEQAFNLKKTSSSGLYKVQIGAFKVKANADSLASNAEAKGFDSIVLLK DGLYKVQIGAFSSKDNADTLAARAKNAGFDAIVILES*" /label="cwlC CDS" gene complement(1710185..1710952) /gene="cwlC" /locus_tag="BSU_17410" /old_locus_tag="BSU17410" /label="cwlC gene" promotor_-10 complement(1710961..1710980) /Source="Nicolas_upshift_promotors" /id="U1390" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1431 /SigmaFactorBS="tgtgaaagggttatttcctcatttttcagttgaatgataatc GTACAAGCAGaagccgtgttttTTCATATCCTGTAATGAGGTgatgaaaaatggttaa a" /listShort="cwlC, S622" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1710984) /Source="Nicolas_upshifts" /id="U1390" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1431 /SigmaFactorBS="tgtgaaagggttatttcctcatttttcagttgaatgataatc GTACAAGCAGaagccgtgttttTTCATATCCTGTAATGAGGTgatgaaaaatggttaa a" /listShort="cwlC, S622" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1710993..1711002) /Source="Nicolas_upshift_promotors" /id="U1390" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1431 /SigmaFactorBS="tgtgaaagggttatttcctcatttttcagttgaatgataatc GTACAAGCAGaagccgtgttttTTCATATCCTGTAATGAGGTgatgaaaaatggttaa a" /listShort="cwlC, S622" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1711106..1711111 /Source="Nicolas_upshift_promotors" /id="U1391" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.828171828171828" /psig="0.828171828171828" /xcortree=1459 /SigmaFactorBS="agcgcacaattcaacatgaagcgacaacagatacggtccGAC ATGaaatctgtgcatacgCCATATGTTTGTATGTACTatgggttcggttaacctgcac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1711127..1711145 /Source="Nicolas_upshift_promotors" /id="U1391" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.828171828171828" /psig="0.828171828171828" /xcortree=1459 /SigmaFactorBS="agcgcacaattcaacatgaagcgacaacagatacggtccGAC ATGaaatctgtgcatacgCCATATGTTTGTATGTACTatgggttcggttaacctgcac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1711127 /Source="Nicolas_upshifts" /id="U1391" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.828171828171828" /psig="0.828171828171828" /xcortree=1459 /SigmaFactorBS="agcgcacaattcaacatgaagcgacaacagatacggtccGAC ATGaaatctgtgcatacgCCATATGTTTGTATGTACTatgggttcggttaacctgcac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1711409..1711414 /Source="Nicolas_upshift_promotors" /id="U1392" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.777222777222777" /psig="0.777222777222777" /xcortree=1148 /SigmaFactorBS="tactctgacaaaatgattaaaaacaaaatctcatGGTTTGtc caccccatgtccgtGAATACAATAAGAAATAAAgtatttctcgggaaagcgcaggatt c" /listShort="S624, spoVK" /listLong="ynbA, ynbB" /label="promotor_-35" promotor_-10 1711431..1711449 /Source="Nicolas_upshift_promotors" /id="U1392" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.777222777222777" /psig="0.777222777222777" /xcortree=1148 /SigmaFactorBS="tactctgacaaaatgattaaaaacaaaatctcatGGTTTGtc caccccatgtccgtGAATACAATAAGAAATAAAgtatttctcgggaaagcgcaggatt c" /listShort="S624, spoVK" /listLong="ynbA, ynbB" /label="promotor_-10" S_feature 1711435..1711575 /Source="Nicolas_S_feature" /locus_tag="new_1874062_1874202" /HighExp="S4, S5, S6, S8, S3, B60, LoTm, S7, T5.0H, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.777" /TUlongSig="NA" /TUlongPSig="NA" /label="S624" upshifts 1711435 /Source="Nicolas_upshifts" /id="U1392" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.777222777222777" /psig="0.777222777222777" /xcortree=1148 /SigmaFactorBS="tactctgacaaaatgattaaaaacaaaatctcatGGTTTGtc caccccatgtccgtGAATACAATAAGAAATAAAgtatttctcgggaaagcgcaggatt c" /listShort="S624, spoVK" /listLong="ynbA, ynbB" /label="upshifts" CDS 1711576..1712544 /gene="spoVK" /locus_tag="BSU_17420" /old_locus_tag="BSU17420" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8464402, 22882546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8464402, 22882546; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="mother cell sporulation ATPase" /protein_id="NP_389624.2" /db_xref="EnsemblGenomes-Gn:BSU17420" /db_xref="EnsemblGenomes-Tr:CAB13626" /db_xref="GOA:P27643" /db_xref="InterPro:IPR000641" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR003959" /db_xref="InterPro:IPR014232" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11039" /db_xref="UniProtKB/Swiss-Prot:P27643" /translation="MLERAVTYKNNGQINIILNGQKQVLTNAEAEAEYQAALQKNEAK HGILKEIEKEMSALVGMEEMKRNIKEIYAWIFVNQKRAEQGLKVGKQALHMMFKGNPG TGKTTVARLIGKLFFEMNVLSKGHLIEAERADLVGEYIGHTAQKTRDLIKKSLGGILF IDEAYSLARGGEKDFGKEAIDTLVKHMEDKQHEFILILAGYSREMDHFLSLNPGLQSR FPISIDFPDYSVTQLMEIAKRMIDEREYQLSQEAEWKLKDYLMTVKSTTSPIKFSNGR FVRNVIEKSIRAQAMRLLMGDQYLKSDLMTIKSQDLSIKEEASGSA*" /label="spoVK CDS" gene 1711576..1712544 /gene="spoVK" /locus_tag="BSU_17420" /old_locus_tag="BSU17420" /label="spoVK gene" downshifts 1712513 /Source="Nicolas_upshifts" /id="D943" /incds=0 /nref=5 /ntot=41 /MaxReadThrough="2.7881" /MaxDrop="5.20495" /score="22.9164064" /energy="-15.5" /TU="U1392" /idTUdmin="U1392" /TUdmin="-109" /isTUend="FALSE" /label="downshifts" promotor_-35 1712608..1712616 /Source="Nicolas_upshift_promotors" /id="U1393" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.879120879120879" /psig=1 /xcortree=1849 /SigmaFactorBS="ggtctgttttttgctcgtatttccgcttttcaaagcaatcga tttGTGGTATACacatgcagggTTTGGTATGATAATACTACTgcccaatatgcaaaag a" /listShort="ynbA, ynbB, glnR, glnA" /listLong="S625, ynxB, S626, ynzF, ynzG, S627, ynaB, ynaC" /label="promotor_-35" upshifts 1712623 /Source="Nicolas_upshifts" /id="U1393" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.879120879120879" /psig=1 /xcortree=1849 /SigmaFactorBS="ggtctgttttttgctcgtatttccgcttttcaaagcaatcga tttGTGGTATACacatgcagggTTTGGTATGATAATACTACTgcccaatatgcaaaag a" /listShort="ynbA, ynbB, glnR, glnA" /listLong="S625, ynxB, S626, ynzF, ynzG, S627, ynaB, ynaC" /label="upshifts" promotor_-10 1712627..1712646 /Source="Nicolas_upshift_promotors" /id="U1393" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.879120879120879" /psig=1 /xcortree=1849 /SigmaFactorBS="ggtctgttttttgctcgtatttccgcttttcaaagcaatcga tttGTGGTATACacatgcagggTTTGGTATGATAATACTACTgcccaatatgcaaaag a" /listShort="ynbA, ynbB, glnR, glnA" /listLong="S625, ynxB, S626, ynzF, ynzG, S627, ynaB, ynaC" /label="promotor_-10" CDS 1712677..1713939 /gene="hflX" /locus_tag="BSU_17430" /old_locus_tag="BSU17430" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 19824612, 26458047, 26733579, 26951678, 27398305; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribosome-splitting GTPase (also ATPase, rescuingstalled ribosomes, E-site binding)" /protein_id="NP_389625.2" /db_xref="EnsemblGenomes-Gn:BSU17430" /db_xref="EnsemblGenomes-Tr:CAB13627" /db_xref="GOA:P94478" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR016496" /db_xref="InterPro:IPR025121" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030394" /db_xref="InterPro:IPR032305" /db_xref="SubtiList:BG12263" /db_xref="UniProtKB/Swiss-Prot:P94478" /translation="MNEQETIQEKAILVGCQLPHITDEHFENSMEELASLTKTADGKV LTSVTQKRNRADAATYIGKGKVEELKALVEELEADLLIFNDELSPSQLKSLATAIEVK MIDRTQLILDIFAKRARTREGKLQIELAQLQYALPRLTGQGINLSRQGGGIGARGPGE TKLETDRRHIRNRIHEINTQLSTVIRHRSRYRERRKKNGVLQIALVGYTNAGKSTWFN RLTSADSYEEDLLFATLDPMTRKMVLPSGYSVLLSDTVGFIQDLPTTLIAAFRSTLEE VKEADLILHLIDSSNEDYAGHEKTVLRLLEELEADDIPMLTAYNKRDQKLPDFIPTAG RDHIMVSAKFEDDAAAFKEAIQRYLRQELLTSFEAHVPASEGKLLSRIKSETMVDRFY FNEENEQYDISGYVQEEQSIIGELKKYM*" /label="hflX CDS" gene 1712677..1713939 /gene="hflX" /locus_tag="BSU_17430" /old_locus_tag="BSU17430" /label="hflX gene" CDS 1713957..1715222 /gene="ynbB" /locus_tag="BSU_17440" /old_locus_tag="BSU17440" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22333191, 24610841; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative C-S lyase" /protein_id="NP_389626.2" /db_xref="EnsemblGenomes-Gn:BSU17440" /db_xref="EnsemblGenomes-Tr:CAB13628" /db_xref="GOA:P94479" /db_xref="InterPro:IPR000277" /db_xref="InterPro:IPR009651" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG12264" /db_xref="UniProtKB/Swiss-Prot:P94479" /translation="MFDTLTHGELLKKTAMEVEADIAGIHKQIEEISERNEWRVLQSY RKHKVSDTHFTPSTGYGYDDIGRDTLESIYADVFGGEAGLVRPQIISGTHAISIALFG VLRPGDELLYITGKPYDTLEEIVGVRGGENAGSLKDFQIGYNAVDLTKDGKIDYDAVA AAINPKTKVIGIQRSKGYANRPSFLISEIKEMIRFVKEINENLIVFVDNCYGEFVEEL EPCHVGADLMAGSLIKNPGGGLAKTGGYLVGKAKWIEACSYRMTSPGIGREAGASLYS LQEMYQGFFLAPHVVSQSLKGAVFTARFLEKLGFTSNPKWDAKRTDLIQSVEFSDREK MIAFCQAIQFASPINAHVTPYPAYMPGYEDDVIMAAGTFIQGASIELSADGPIRPPYV AYVQGGLTYSHVKNAICSAVDSLMQKQLI*" /label="ynbB CDS" gene 1713957..1715222 /gene="ynbB" /locus_tag="BSU_17440" /old_locus_tag="BSU17440" /label="ynbB gene" promotor_-35 1715270..1715277 /Source="Nicolas_upshift_promotors" /id="U1394" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2196 /SigmaFactorBS="atttgatgttaagaatccttacatcgTATTGACAcataatat aacatcACCTATAATGAAACTAAGTTaagaaaaggaggaaattgagatgagtgataat a" /listShort="glnR, glnA, S625, ynxB, S626, ynzF, ynzG" /listLong="S627, ynaB, ynaC" /label="promotor_-35" promotor_-10 1715292..1715311 /Source="Nicolas_upshift_promotors" /id="U1394" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2196 /SigmaFactorBS="atttgatgttaagaatccttacatcgTATTGACAcataatat aacatcACCTATAATGAAACTAAGTTaagaaaaggaggaaattgagatgagtgataat a" /listShort="glnR, glnA, S625, ynxB, S626, ynzF, ynzG" /listLong="S627, ynaB, ynaC" /label="promotor_-10" upshifts 1715304 /Source="Nicolas_upshifts" /id="U1394" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2196 /SigmaFactorBS="atttgatgttaagaatccttacatcgTATTGACAcataatat aacatcACCTATAATGAAACTAAGTTaagaaaaggaggaaattgagatgagtgataat a" /listShort="glnR, glnA, S625, ynxB, S626, ynzF, ynzG" /listLong="S627, ynaB, ynaC" /label="upshifts" CDS 1715332..1715739 /gene="glnR" /locus_tag="BSU_17450" /old_locus_tag="BSU17450" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9287005, 12374841, 16547045, 16885465, 22625175, 22720735, 25691471" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9287005, 12374841, 16547045, 16885465, 22625175, 22720735, 25691471; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (nitrogen metabolism)" /protein_id="NP_389627.1" /db_xref="EnsemblGenomes-Gn:BSU17450" /db_xref="EnsemblGenomes-Tr:CAB13629" /db_xref="GOA:P37582" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="PDB:4R4E" /db_xref="SubtiList:BG10424" /db_xref="UniProtKB/Swiss-Prot:P37582" /translation="MSDNIRRSMPLFPIGIVMQLTELSARQIRYYEENGLIFPARSEG NRRLFSFHDVDKLLEIKHLIEQGVNMAGIKQILAKAEAEPEQKQNEKTKKPMKHDLSD DELRQLLKNELMQAGRFQRGNTFRQGDMSRFFH*" /label="glnR CDS" gene 1715332..1715739 /gene="glnR" /locus_tag="BSU_17450" /old_locus_tag="BSU17450" /label="glnR gene" downshifts complement(1715338) /Source="Nicolas_upshifts" /id="D944" /incds=0 /nref=2 /ntot=82 /MaxReadThrough="1.78139" /MaxDrop="3.45896" /score="-7.83781174" /energy="-10.3" /TU="NA" /idTUdmin="U1398" /TUdmin=3816 /isTUend="FALSE" /label="downshifts" misc_feature 1715720..1715738 /Source="Nicolas_upshift_promotors" /id="U1395" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.777222777222777" /psig="0.777222777222777" /xcortree=2197 /SigmaFactorBS="ttttcaaagagggaatacattccgtcaaggcgacaTGTCCCG CTTCTTTCATTAatccgttagcaactgttttgctatatacatttaccttttaagagga g" /listShort="glnA, S625, ynxB, S626" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1715745 /Source="Nicolas_upshifts" /id="U1395" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.777222777222777" /psig="0.777222777222777" /xcortree=2197 /SigmaFactorBS="ttttcaaagagggaatacattccgtcaaggcgacaTGTCCCG CTTCTTTCATTAatccgttagcaactgttttgctatatacatttaccttttaagagga g" /listShort="glnA, S625, ynxB, S626" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(1715798) /Source="Nicolas_upshifts" /id="D945" /incds=0 /nref=1 /ntot=72 /MaxReadThrough="1.70567" /MaxDrop="3.42395" /score="-7.83781174" /energy="-10.3" /TU="NA" /idTUdmin="U1398" /TUdmin=3356 /isTUend="FALSE" /label="downshifts" CDS 1715798..1717132 /gene="glnA" /locus_tag="BSU_17460" /old_locus_tag="BSU17460" /EC_number="6.3.1.2" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:13737, 11719184, 12142436, 16055443, 16885465, 19233925, 19251843" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 13737, 11719184, 12142436, 16055443, 16885465, 19233925, 19251843; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamine synthetase" /protein_id="NP_389628.1" /db_xref="EnsemblGenomes-Gn:BSU17460" /db_xref="EnsemblGenomes-Tr:CAB13630" /db_xref="GOA:P12425" /db_xref="InterPro:IPR001637" /db_xref="InterPro:IPR004809" /db_xref="InterPro:IPR008146" /db_xref="InterPro:IPR008147" /db_xref="InterPro:IPR014746" /db_xref="InterPro:IPR027302" /db_xref="InterPro:IPR027303" /db_xref="InterPro:IPR036651" /db_xref="PDB:2FWX" /db_xref="PDB:4LNF" /db_xref="PDB:4LNI" /db_xref="PDB:4LNK" /db_xref="PDB:4LNN" /db_xref="PDB:4LNO" /db_xref="PDB:4S0R" /db_xref="SubtiList:BG10425" /db_xref="UniProtKB/Swiss-Prot:P12425" /translation="MAKYTREDIEKLVKEENVKYIRLQFTDILGTIKNVEIPVSQLGK ALDNKVMFDGSSIEGFVRIEESDMYLYPDLNTFVIFPWTAEKGKVARFICDIYNPDGT PFEGDPRNNLKRILKEMEDLGFSDFNLGPEPEFFLFKLDEKGEPTLELNDKGGYFDLA PTDLGENCRRDIVLELEEMGFEIEASHHEVAPGQHEIDFKYAGAVRSCDDIQTFKLVV KTIARKHGLHATFMPKPLFGVNGSGMHCNLSLFKNGVNAFFDENADLQLSETAKHFIA GIVKHATSFTAVTNPTVNSYKRLVPGYEAPCYVAWSAQNRSPLIRIPASRGISTRVEV RSVDPAANPYLALSVLLAAGLDGIKNKLEAPAPIDRNIYVMSKEERMENGIVDLPATL AEALEEFKSNEVMVKALGEHLFEHFIEAKEIEWDMFRTQVHPWEREQYMSQY*" /label="glnA CDS" gene 1715798..1717132 /gene="glnA" /locus_tag="BSU_17460" /old_locus_tag="BSU17460" /label="glnA gene" downshifts 1717109 /Source="Nicolas_upshifts" /id="D946" /incds=0 /nref=266 /ntot=287 /MaxReadThrough="5.53201" /MaxDrop="7.28613" /score="29.7599306" /energy="-16.4" /TU="U1394,U1395" /idTUdmin="U1393" /TUdmin=1 /isTUend="TRUE" /label="downshifts" S_feature 1717154..>1717203 /Source="Nicolas_S_feature" /locus_tag="new_1879781_1880041" /HighExp="Cold, BT, LBGtran, G135, G180, Etha, G150, LBGexp, Oxctl, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigL, SigA" /TUshortPSig="0.777, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S625" SCAR 1717203..1717204 /created_by="User" /note="deletion occured in betwen marked nucleotides" /modified_by="User" /label="IIG_Bs04" S_feature <1717204..1717956 /Source="Nicolas_S_feature" /locus_tag="new_1886528_1887351" /HighExp="Lbstat, M0t90, S8, C30, Pyr, Lbtran, M40t90, S1, M/G, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S631" promotor_-10 complement(1717296..1717314) /Source="Nicolas_upshift_promotors" /id="U1402" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1005 /SigmaFactorBS="gtcatgaattgaaagaacggaatggccagaatagtttatGTT ATAagtccaaccctacatACATATATCAATACAGGAAagataaataagaagcaaaaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1717314) /Source="Nicolas_upshifts" /id="U1402" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1005 /SigmaFactorBS="gtcatgaattgaaagaacggaatggccagaatagtttatGTT ATAagtccaaccctacatACATATATCAATACAGGAAagataaataagaagcaaaaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1717330..1717335) /Source="Nicolas_upshift_promotors" /id="U1402" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1005 /SigmaFactorBS="gtcatgaattgaaagaacggaatggccagaatagtttatGTT ATAagtccaaccctacatACATATATCAATACAGGAAagataaataagaagcaaaaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1717957..1719348 /gene="xynP" /locus_tag="BSU_17570" /old_locus_tag="BSU17570" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16684115, 16850406, 17183216, 20406496; Product type t : transporter" /codon_start=1 /transl_table=11 /product="H+-xyloside symporter" /protein_id="NP_389639.2" /db_xref="EnsemblGenomes-Gn:BSU17570" /db_xref="EnsemblGenomes-Tr:CAB13641" /db_xref="GOA:P94488" /db_xref="InterPro:IPR001927" /db_xref="InterPro:IPR018043" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12262" /db_xref="UniProtKB/Swiss-Prot:P94488" /translation="MLSENVKKISMVEKVGYASGDFACNLIYATVSTYLLFFYTDVFG LSAAAAGTMFLVVRIIDALADPFIGTIVDRTNSRFGRFRPYLLFGAFPFVILAILCFT TPDFSDMGKLIYAYITYVGLSLTYTTINVPYGALTSAMTRNNQEVVSITSVRMLFANL GGLVVAFFVPLLAAYLSDTSGNESLGWQLTMGILGMIGGCLLIFCFKSTKERVTLQKS EEKIKFTDIFEQFRVNRPLVVLSIFFIIIFGVNSISNSVGIYYVTYNLEREDLVKWYG LIGSLPALVILPFIPRLHQFLGKKKLLNYALLLNIIGLLALLFVPPSNVYLILVCRLI AAAGSLTAGGYMWALIPETIEYGEYRTGKRMGGLIYAIIGFFFKFGMALGGVVPGLVL DKFGYVANQAQTPAALMGILITTTIIPVFLLVLALIDINFYNLDEKKYKNMVRELENR DKVYLDHIDDFKA*" /label="xynP CDS" gene 1717957..1719348 /gene="xynP" /locus_tag="BSU_17570" /old_locus_tag="BSU17570" /label="xynP gene" CDS 1719379..1720980 /gene="xynB" /locus_tag="BSU_17580" /old_locus_tag="BSU17580" /EC_number="3.2.1.37" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 2440680, 6413490, 7816035, 9286998, 9973552, 16684115, 28066362; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xylan beta-1,4-xylosidase" /protein_id="NP_389640.2" /db_xref="EnsemblGenomes-Gn:BSU17580" /db_xref="EnsemblGenomes-Tr:CAB13642" /db_xref="GOA:P94489" /db_xref="InterPro:IPR006710" /db_xref="InterPro:IPR013320" /db_xref="InterPro:IPR023296" /db_xref="PDB:1YIF" /db_xref="SubtiList:BG11987" /db_xref="UniProtKB/Swiss-Prot:P94489" /translation="MKITNPVLKGFNPDPSICRAGEDYYIAVSTFEWFPGVQIHHSKD LVNWHLVAHPLQRVSQLDMKGNPNSGGVWAPCLSYSDGKFWLIYTDVKVVDGAWKDCH NYLVTCETINGDWSEPIKLNSSGFDASLFHDTDGKKYLLNMLWDHRIDRHSFGGIVIQ EYSDKEQKLIGKPKVIFEGTDRKLTEAPHLYHIGNYYYLLTAEGGTRYEHAATIARSA NIEGPYEVHPDNPILTSWHDPGNPLQKCGHASIVQTHTDEWYLAHLTGRPIHPDDDSI FQQRGYCPLGRETAIQKLYWKDEWPYVVGGKEGSLEVDAPSIPETIFEATYPEVDEFE DSTLNINFQTLRIPFTNELGSLTQAPNHLRLFGHESLTSTFTQAFVARRWQSLHFEAE TAVEFYPENFQQAAGLVNYYNTENWTALQVTHDEELGRILELTICDNFSFSQPLNNKI VIPREVKYVYLRVNIEKDKYYYFYSFNKEDWHKIDIALESKKLSDDYIRGGGFFTGAF VGMQCQDTSGNHIPADFRYFRYKEK*" /label="xynB CDS" gene 1719379..1720980 /gene="xynB" /locus_tag="BSU_17580" /old_locus_tag="BSU17580" /label="xynB gene" S_feature complement(1719495..1719800) /Source="Nicolas_S_feature" /locus_tag="new_1888890_1889195_c" /HighExp="S8, S6, S7, BT, C30, S5, Pyr, S4, B36, BC" /AntisenseName="xynB" /AntisenseCor="6.2527836498644102E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.985" /TUlongSig="NA" /TUlongPSig="NA" /label="S632" promotor_-10 complement(1719795..1719814) /Source="Nicolas_upshift_promotors" /id="U1403" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1333 /SigmaFactorBS="tcctgtataacaattcctccaaatGAGTGCCGAtcaatacgg tgatCCCATAACATATTTAATAAAtacttttttccatccgtatcatggaacaaagaag c" /listShort="S632" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1719800) /Source="Nicolas_upshifts" /id="U1403" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1333 /SigmaFactorBS="tcctgtataacaattcctccaaatGAGTGCCGAtcaatacgg tgatCCCATAACATATTTAATAAAtacttttttccatccgtatcatggaacaaagaag c" /listShort="S632" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1719828..1719836) /Source="Nicolas_upshift_promotors" /id="U1403" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1333 /SigmaFactorBS="tcctgtataacaattcctccaaatGAGTGCCGAtcaatacgg tgatCCCATAACATATTTAATAAAtacttttttccatccgtatcatggaacaaagaag c" /listShort="S632" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1720978 /Source="Nicolas_upshifts" /id="D951" /incds=0 /nref=2 /ntot=53 /MaxReadThrough="1.32947" /MaxDrop="3.8449" /score="13.0570501" /energy="-10.2" /TU="NA" /idTUdmin="U1400" /TUdmin=3190 /isTUend="FALSE" /label="downshifts" CDS complement(1721117..1722271) /gene="xylR" /locus_tag="BSU_17590" /old_locus_tag="BSU17590" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1588910, 1719948, 2544559, 7559331; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator" /protein_id="NP_389641.3" /db_xref="EnsemblGenomes-Gn:BSU17590" /db_xref="EnsemblGenomes-Tr:CAB13643" /db_xref="GOA:P94490" /db_xref="InterPro:IPR000600" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11986" /db_xref="UniProtKB/Swiss-Prot:P94490" /translation="MDIADQTFVKKVNQKLLLKEILKNSPISRAKLSEMTGLNKSTVS SQVNTLMKESMVFEIGQGQSSGGRRPVMLVFNKKAGYSVGIDVGVDYINGILTDLEGT IVLDQYRHLESNSPEITKDILIDMIHHFITQMPQSPYGLIGIGICVPGLIDKDQKIVF TPNSNWRDIDLKSSIQEKYNVPVFIENEANAGAYGEKVFGAAKNHDNIIYVSISTGIG IGVIINNHLYRGVSGFSGEMGHMTIDFNGPKCSCGNRGCWELYASEKALLKSLQTKEK KLSYQDIINLAHLNDIGTLNALQNFGFYLGIGLTNILNTFNPQAVILRNSIIESHPMV LNSMRSEVSSRVYSQLGNSYELLPSSLGQNAPALGMSSIVIDHFLDMITM*" /label="xylR CDS" gene complement(1721117..1722271) /gene="xylR" /locus_tag="BSU_17590" /old_locus_tag="BSU17590" /label="xylR gene" downshifts complement(1721120) /Source="Nicolas_upshifts" /id="D952" /incds=0 /nref=9 /ntot=198 /MaxReadThrough="2.56326" /MaxDrop="4.09398" /score="19.297583" /energy="-7.4" /TU="NA" /idTUdmin="U1405" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1722170..1722348) /Source="Nicolas_S_feature" /locus_tag="new_1891565_1891743_c" /HighExp="dia15, Etha, dia5, dia0, Cold, LBGstat, Lbexp, M0t45, Diami, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S633" promotor_-35 1722316..1722322 /Source="Nicolas_upshift_promotors" /id="U1404" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.48951048951049" /psig="0.487512487512487" /xcortree=661 /SigmaFactorBS="ccatttgtttaatctttaaattaagtatcaacatAGTACATa gcgaatctTCCCTTTATTATATCTAatgtgttcataaaaaactaaaaaaaatattgaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1722331..1722350) /Source="Nicolas_upshift_promotors" /id="U1405" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=1893 /SigmaFactorBS="ttcatcttatataacctcgtcagtattttcaatattttttTT AGttttttatgaacacATTAGATATAATAAAGGGAAgattcgctatgtactatgttga t" /listShort="S633, xylR" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 1722332..1722348 /Source="Nicolas_upshift_promotors" /id="U1404" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.48951048951049" /psig="0.487512487512487" /xcortree=661 /SigmaFactorBS="ccatttgtttaatctttaaattaagtatcaacatAGTACATa gcgaatctTCCCTTTATTATATCTAatgtgttcataaaaaactaaaaaaaatattgaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1722342 /Source="Nicolas_upshifts" /id="U1404" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.48951048951049" /psig="0.487512487512487" /xcortree=661 /SigmaFactorBS="ccatttgtttaatctttaaattaagtatcaacatAGTACATa gcgaatctTCCCTTTATTATATCTAatgtgttcataaaaaactaaaaaaaatattgaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1722348) /Source="Nicolas_upshifts" /id="U1405" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=1893 /SigmaFactorBS="ttcatcttatataacctcgtcagtattttcaatattttttTT AGttttttatgaacacATTAGATATAATAAAGGGAAgattcgctatgtactatgttga t" /listShort="S633, xylR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1722365..1722368) /Source="Nicolas_upshift_promotors" /id="U1405" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=1893 /SigmaFactorBS="ttcatcttatataacctcgtcagtattttcaatattttttTT AGttttttatgaacacATTAGATATAATAAAGGGAAgattcgctatgtactatgttga t" /listShort="S633, xylR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1722375..1722382 /Source="Nicolas_upshift_promotors" /id="U1406" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.973026973026973" /psig=1 /xcortree=1568 /SigmaFactorBS="atgtgttcataaaaaactaaaaaaaaTATTGAAAatactgac gaggttATATAAGATGAAAATAAGTTagtttgtttaaacaacaaactaataggtgatg t" /listShort="S634, xylA, S635, xylB, S636" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1722397..1722416 /Source="Nicolas_upshift_promotors" /id="U1406" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.973026973026973" /psig=1 /xcortree=1568 /SigmaFactorBS="atgtgttcataaaaaactaaaaaaaaTATTGAAAatactgac gaggttATATAAGATGAAAATAAGTTagtttgtttaaacaacaaactaataggtgatg t" /listShort="S634, xylA, S635, xylB, S636" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1722408..1722512 /Source="Nicolas_S_feature" /locus_tag="new_1891803_1891907" /HighExp="dia15, dia0, Lbexp, dia5, B60, Sw, G150, LPhT, Mt0, M0t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S634" upshifts 1722409 /Source="Nicolas_upshifts" /id="U1406" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.973026973026973" /psig=1 /xcortree=1568 /SigmaFactorBS="atgtgttcataaaaaactaaaaaaaaTATTGAAAatactgac gaggttATATAAGATGAAAATAAGTTagtttgtttaaacaacaaactaataggtgatg t" /listShort="S634, xylA, S635, xylB, S636" /GFF_Attribute="listLong" /label="upshifts" CDS 1722513..1723850 /gene="xylA" /locus_tag="BSU_17600" /old_locus_tag="BSU17600" /EC_number="5.3.1.5" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7663444, 8132469" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7663444, 8132469; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xylose isomerase" /protein_id="NP_389642.2" /db_xref="EnsemblGenomes-Gn:BSU17600" /db_xref="EnsemblGenomes-Tr:CAB13644" /db_xref="GOA:P0CI80" /db_xref="InterPro:IPR001998" /db_xref="InterPro:IPR013022" /db_xref="InterPro:IPR013452" /db_xref="InterPro:IPR036237" /db_xref="SubtiList:BG10806" /db_xref="UniProtKB/Swiss-Prot:P0CI80" /translation="MAQSHSSSINYFGSANKVVYEGKDSTNPLAFKYYNPQEVIGGKT LKEHLRFSIAYWHTFTADGTDVFGAATMQRPWDHYKGMDLAKMRVEAAFEMFEKLDAP FFAFHDRDIAPEGSTLKETNQNLDMIMGMIKDYMRNSGVKLLWNTANMFTNPRFVHGA ATSCNADVFAYAAAQVKKGLETAKELGAENYVFWGGREGYETLLNTDLKFELDNLARF MHMAVDYAKEIGYTGQFLIEPKPKEPTTHQYDTDAATTIAFLKQYGLDNHFKLNLEAN HATLAGHTFEHELRMARVHGLLGSVDANQGHPLLGWDTDEFPTDLYSTTLAMYEILQN GGLGSGGLNFDAKVRRSSFEPDDLIYAHIAGMDAFARGLKVAHKLIEDRVFEDVIQHR YRSFTEGIGLEIIEGRANFHTLEQYALNHKSIKNESGRQEKLKAILNQYILEV*" /label="xylA CDS" gene 1722513..1723850 /gene="xylA" /locus_tag="BSU_17600" /old_locus_tag="BSU17600" /label="xylA gene" S_feature 1723851..1723925 /Source="Nicolas_S_feature" /locus_tag="new_1893246_1893320" /HighExp="dia0, dia15, Sw, Lbexp, dia5, B60, Mt0, M0t45, G150, LPhT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S635" downshifts 1723882 /Source="Nicolas_upshifts" /id="D953" /incds=0 /nref=1 /ntot=3 /MaxReadThrough="4.89699" /MaxDrop="3.40404" /score="13.0570501" /energy="-10.2" /TU="U1406" /idTUdmin="U1406" /TUdmin="-1892" /isTUend="FALSE" /label="downshifts" CDS 1724001..1725500 /gene="xylB" /locus_tag="BSU_17610" /old_locus_tag="BSU17610" /EC_number="2.7.1.17" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1660563, 8866023, 27467131; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xylulose kinase" /protein_id="NP_389643.1" /db_xref="EnsemblGenomes-Gn:BSU17610" /db_xref="EnsemblGenomes-Tr:CAB13645" /db_xref="GOA:P39211" /db_xref="InterPro:IPR000577" /db_xref="InterPro:IPR006000" /db_xref="InterPro:IPR018483" /db_xref="InterPro:IPR018484" /db_xref="InterPro:IPR018485" /db_xref="SubtiList:BG10807" /db_xref="UniProtKB/Swiss-Prot:P39211" /translation="MKYVIGIDLGTSAVKTILVNQNGKVCAETSKRYPLIQEKAGYSE QNPEDWVQQTIEALAELVSISNVQAKDIDGISYSGQMHGLVLLDQDRQVLRNAILWND TRTTPQCIRMTEKFGDHLLDITKNRVLEGFTLPKMLWVKEHEPELFKKTAVFLLPKDY VRFRMTGVIHTEYSDAAGTLLLHITRKEWSNDICNQIGISADICPPLVESHDCVGSLL PHVAAKTGLLEKTKVYAGGADNACGAIGAGILSSGKTLCSIGTSGVILSYEEEKERDF KGKVHFFNHGKKDSFYTMGVTLAAGYSLDWFKRTFAPNESFEQLLQGVEAIPIGANGL LYTPYLVGERTPHADSSIRGSLIGMDGAHNRKHFLRAIMEGITFSLHESIELFREAGK SVHTVVSIGGGAKNDTWLQMQADIFNTRVIKLENEQGPAMGAAMLAAFGSGWFESLEE CAEQFIREAAAFYPKAQNVQKYKTLFDLYKNIYTHTKDLNTALKSFRKN*" /label="xylB CDS" gene 1724001..1725500 /gene="xylB" /locus_tag="BSU_17610" /old_locus_tag="BSU17610" /label="xylB gene" S_feature 1725501..1725816 /Source="Nicolas_S_feature" /locus_tag="new_1894896_1895211" /HighExp="dia0, dia15, Lbexp, dia5, Mt0, M0t45, G150, Etha, Diami, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.51323200000000002" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S636" downshifts 1725774 /Source="Nicolas_upshifts" /id="D954" /incds=0 /nref=60 /ntot=197 /MaxReadThrough="0.61776" /MaxDrop="5.13425" /score="13.0570501" /energy="-10.2" /TU="NA" /idTUdmin="U1406" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1725983..1726618) /gene="yncB" /locus_tag="BSU_17620" /old_locus_tag="BSU17620" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11584000" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11584000; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA nuclease, lipoprotein (phage origin)" /protein_id="NP_389644.1" /db_xref="EnsemblGenomes-Gn:BSU17620" /db_xref="EnsemblGenomes-Tr:CAB13646" /db_xref="GOA:P94492" /db_xref="InterPro:IPR002071" /db_xref="InterPro:IPR016071" /db_xref="InterPro:IPR035437" /db_xref="SubtiList:BG12265" /db_xref="UniProtKB/Swiss-Prot:P94492" /translation="MKKILISMIAIVLSITLAACGSNHAAKNHSDSNGTEQVSQDTHS NEYNQTEQKAGTPHSKNQKKLVNVTLDRAIDGDTIKVIYNGKKDTVRYLLVDTPETKK PNSCVQPYGEDASKRNKELVNSGKLQLEFDKGDRRDKYGRLLAYVYVDGKSVQETLLK EGLARVAYVYEPNTKYIDQFRLDEQEAKSDKLSIWSKSGYVTNRGFNGCVK*" /label="yncB CDS" gene complement(1725983..1726618) /gene="yncB" /locus_tag="BSU_17620" /old_locus_tag="BSU17620" /label="yncB gene" promotor_-10 complement(1726655..1726674) /Source="Nicolas_upshift_promotors" /id="U1407" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.999000999001" /xcortree=2438 /SigmaFactorBS="gagtgttataagttcccttgaagttttcCATTCACAaaaaat gtccatatCGTTATAATGATGATGTTTAatcgcgaaaagagaaaatgataaagaggga a" /listShort="yncB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1726664) /Source="Nicolas_upshifts" /id="U1407" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.999000999001" /xcortree=2438 /SigmaFactorBS="gagtgttataagttcccttgaagttttcCATTCACAaaaaat gtccatatCGTTATAATGATGATGTTTAatcgcgaaaagagaaaatgataaagaggga a" /listShort="yncB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1726689..1726696) /Source="Nicolas_upshift_promotors" /id="U1407" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.999000999001" /xcortree=2438 /SigmaFactorBS="gagtgttataagttcccttgaagttttcCATTCACAaaaaat gtccatatCGTTATAATGATGATGTTTAatcgcgaaaagagaaaatgataaagaggga a" /listShort="yncB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1726806..1726813 /Source="Nicolas_upshift_promotors" /id="U1408" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=321 /SigmaFactorBS="ccatcacatagcggaaataaataatcctgaaaataaTATTGA CTgaaaatgcttttagAATTATGATAATATGAGAAAtgacaataatgtgacaaagaca t" /listShort="S637, yncC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1726828..1726847 /Source="Nicolas_upshift_promotors" /id="U1408" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=321 /SigmaFactorBS="ccatcacatagcggaaataaataatcctgaaaataaTATTGA CTgaaaatgcttttagAATTATGATAATATGAGAAAtgacaataatgtgacaaagaca t" /listShort="S637, yncC" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1726830..1727028 /Source="Nicolas_S_feature" /locus_tag="new_1896225_1896423" /HighExp="T0.30H, Lbtran, T1.0H, M9-stat, M0t90, T1.30H, M40t90, T2.0H, T0.0H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S637" upshifts 1726830 /Source="Nicolas_upshifts" /id="U1408" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=321 /SigmaFactorBS="ccatcacatagcggaaataaataatcctgaaaataaTATTGA CTgaaaatgcttttagAATTATGATAATATGAGAAAtgacaataatgtgacaaagaca t" /listShort="S637, yncC" /GFF_Attribute="listLong" /label="upshifts" CDS 1727029..1728444 /gene="yncC" /locus_tag="BSU_17630" /old_locus_tag="BSU17630" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22900538, 23569278; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative sugar transporter" /protein_id="NP_389645.2" /db_xref="EnsemblGenomes-Gn:BSU17630" /db_xref="EnsemblGenomes-Tr:CAB13647" /db_xref="GOA:P94493" /db_xref="InterPro:IPR003663" /db_xref="InterPro:IPR005828" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12266" /db_xref="UniProtKB/Swiss-Prot:P94493" /translation="MDMNEHRNRRLKLIMISATFGGLLFGYDTGVINGALPFMARPDQ LDLTPVTEGLVTSILLLGAAFGALLCGRLADRYGRRKMILNLSFLFFLASLGTALAPN VFIMAVFRFLLGLAVGGASAMVPAFLAEMAPHEKRGRMVTQNELMIVGGQFLAYVFNA ILGVTMANTGHVWRYMLVICAVPAIMLFASMLKVPESPRWLISKGKNSEALRVLKQIR EDKRAEAECREIQEAVEKDTALEKASLKDFSTPWLRRLLWIGIGVAIVNQITGVNSIM YYGTQILKESGFGTKAALIANIGNGLISVIAVIFGIWLVGKVRRRPILLIGLAGTTTA LLLIAIFSIVLDGSMALPYVVLSLTVLFLAFMQGCVGPVTWLVIAEIFPQRLRGLGSG ISVFFLWILNFVIGFAFPILLSSVGLSFTFFIFVALGVLAIGFVYKFMPETKGRTLEE LEEHFRSRHDHNTPEQSVIEV*" /label="yncC CDS" gene 1727029..1728444 /gene="yncC" /locus_tag="BSU_17630" /old_locus_tag="BSU17630" /label="yncC gene" downshifts 1728434 /Source="Nicolas_upshifts" /id="D955" /incds=0 /nref=13 /ntot=69 /MaxReadThrough="0.90595" /MaxDrop="4.35189" /score="15.579587" /energy="-8.6" /TU="NA" /idTUdmin="U1408" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" downshifts complement(1728537) /Source="Nicolas_upshifts" /id="D956" /incds=0 /nref=13 /ntot=41 /MaxReadThrough="1.08869" /MaxDrop="5.39832" /score="24.3759796" /energy="-9.3" /TU="NA" /idTUdmin="U1409" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" CDS complement(1728546..1729730) /gene="alrB" /locus_tag="BSU_17640" /old_locus_tag="BSU17640" /EC_number="5.1.1.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10348844, 18399999" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10348844, 18399999; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alanine racemase (minor activity)" /protein_id="NP_389646.1" /db_xref="EnsemblGenomes-Gn:BSU17640" /db_xref="EnsemblGenomes-Tr:CAB13648" /db_xref="GOA:P94494" /db_xref="InterPro:IPR000821" /db_xref="InterPro:IPR001608" /db_xref="InterPro:IPR009006" /db_xref="InterPro:IPR011079" /db_xref="InterPro:IPR020622" /db_xref="InterPro:IPR029066" /db_xref="PDB:5IRP" /db_xref="SubtiList:BG12267" /db_xref="UniProtKB/Swiss-Prot:P94494" /translation="MIKLCREVWIEVNLDAVKKNLRAIRRHIPHKSKIMAVVKANGYG HGSIEVARHALEHGASELAVASVEEGIVLRKAGITAPILVLGFTSLSCVKKSAAWNIT LSAFQVDWMKEANEILEKEASANRLAIHINVDTGMGRLGVRTKEELLEVVKALKASKF LRWTGIFTHFSTADEPDTTLTKLQHEKFISFLSFLKKQGIELPTVHMCNTAAAIAFPE FSADMIRLGIGLYGLYPSAYIKQLNLVKLEPALSLKARIAYVKTMRTEPRTVSYGATY IAEPNEVIATLPIGYADGYSRALSNRGFVLHRGKRVPVAGRVTMDMIMVSLGENGEGK QGDEVVIYGKQKGAEISVDEVAEMLNTINYEVVSTLSRRIPRFYIRDGEIFKVSTPVL YV*" /label="alrB CDS" gene complement(1728546..1729730) /gene="alrB" /locus_tag="BSU_17640" /old_locus_tag="BSU17640" /label="alrB gene" S_feature complement(1729731..1729810) /Source="Nicolas_S_feature" /locus_tag="new_1899126_1899205_c" /HighExp="S4, S5, S3, S6, S7, B36, BT, S8, LoTm, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.908" /TUlongSig="NA" /TUlongPSig="NA" /label="S638" promotor_-10 complement(1729803..1729821) /Source="Nicolas_upshift_promotors" /id="U1409" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.908091908091908" /psig="0.908091908091908" /xcortree=1129 /SigmaFactorBS="aggcaccttctcgtatcacatggatttgctgtTGAATGattt caaataaagttGAATAAAATAAGATCGAATcatccaacaattaacatttattcttgcg g" /listShort="S638, alrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1729814) /Source="Nicolas_upshifts" /id="U1409" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.908091908091908" /psig="0.908091908091908" /xcortree=1129 /SigmaFactorBS="aggcaccttctcgtatcacatggatttgctgtTGAATGattt caaataaagttGAATAAAATAAGATCGAATcatccaacaattaacatttattcttgcg g" /listShort="S638, alrB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1729837..1729842) /Source="Nicolas_upshift_promotors" /id="U1409" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.908091908091908" /psig="0.908091908091908" /xcortree=1129 /SigmaFactorBS="aggcaccttctcgtatcacatggatttgctgtTGAATGattt caaataaagttGAATAAAATAAGATCGAATcatccaacaattaacatttattcttgcg g" /listShort="S638, alrB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1730122..1730129 /Source="Nicolas_upshift_promotors" /id="U1410" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.687312687312687" /psig="0.996003996003996" /xcortree=2322 /SigmaFactorBS="ataatcggttgaaaaggcagtcgattccttGTTCCATAaacc taacatcagaGTATATAATTATACTCGTATtcacaaaaatcgtttaagtaaggggtat a" /listShort="yncE, yncF, S640, ynzJ, S642, S643, thyA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1730144..1730163 /Source="Nicolas_upshift_promotors" /id="U1410" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.687312687312687" /psig="0.996003996003996" /xcortree=2322 /SigmaFactorBS="ataatcggttgaaaaggcagtcgattccttGTTCCATAaacc taacatcagaGTATATAATTATACTCGTATtcacaaaaatcgtttaagtaaggggtat a" /listShort="yncE, yncF, S640, ynzJ, S642, S643, thyA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1730152 /Source="Nicolas_upshifts" /id="U1410" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.687312687312687" /psig="0.996003996003996" /xcortree=2322 /SigmaFactorBS="ataatcggttgaaaaggcagtcgattccttGTTCCATAaacc taacatcagaGTATATAATTATACTCGTATtcacaaaaatcgtttaagtaaggggtat a" /listShort="yncE, yncF, S640, ynzJ, S642, S643, thyA" /GFF_Attribute="listLong" /label="upshifts" CDS 1730194..1730655 /gene="yncE" /locus_tag="BSU_17650" /old_locus_tag="BSU17650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative prophage protein" /protein_id="NP_389648.2" /db_xref="EnsemblGenomes-Gn:BSU17650" /db_xref="EnsemblGenomes-Tr:CAB13649" /db_xref="InterPro:IPR020216" /db_xref="SubtiList:BG12268" /db_xref="UniProtKB/Swiss-Prot:P94495" /translation="MNRGVSFQIPNEYGNFLWRILQPVEIANYRWQTSGESYFVVEGE LDDEELFHDYEIVEGAVFEQQLKTNQYYTIFVELKAFPYGKMVNQVNTYEEFADSDCE LVLLIADNSYVSIYCKNKNIIEKLYFNALQHDFEDVQFITDENDTRTSLTV*" /label="yncE CDS" gene 1730194..1730655 /gene="yncE" /locus_tag="BSU_17650" /old_locus_tag="BSU17650" /label="yncE gene" CDS 1730685..1731119 /gene="dutA" /locus_tag="BSU_17660" /old_locus_tag="BSU17660" /EC_number="3.6.1.23" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11375514, 15939294, 16908222, 17169987, 21358047, 23897460" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11375514, 15939294, 16908222, 17169987, 21358047, 23897460; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="deoxyuridine 5'-triphosphate pyrophosphatase (phage origin)" /protein_id="NP_389649.1" /db_xref="EnsemblGenomes-Gn:BSU17660" /db_xref="EnsemblGenomes-Tr:CAB13650" /db_xref="GOA:O31801" /db_xref="InterPro:IPR029054" /db_xref="InterPro:IPR033704" /db_xref="InterPro:IPR036157" /db_xref="PDB:2XCD" /db_xref="PDB:2XCE" /db_xref="PDB:4AOO" /db_xref="PDB:4AOZ" /db_xref="PDB:4APZ" /db_xref="PDB:4B0H" /db_xref="SubtiList:BG13437" /db_xref="UniProtKB/Swiss-Prot:O31801" /translation="MTMQIKIKYLDETQTRISKIEQGDWIDLRAAEDVTIKKDEFKLV PLGVAMELPEGYEAHVVPRSSTYKNFGVIQTNSMGVIDESYKGDNDFWFFPAYALRDT EIKKGDRICQFRIMKKMPAVELVEVEHLGNEDRGGLGSTGTK*" /label="dutA CDS" gene 1730685..1731119 /gene="dutA" /locus_tag="BSU_17660" /old_locus_tag="BSU17660" /label="dutA gene" S_feature complement(1730868..1731173) /Source="Nicolas_S_feature" /locus_tag="new_1900263_1900568_c" /HighExp="LoTm, S5, T5.0H, S8, T4.0H, S4, S7, T3.30H, Cold, T-4.40H" /AntisenseName="yncF" /AntisenseCor="-0.40042805081531202" /AntisenseRegPval="-11.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S639" downshifts 1730966 /Source="Nicolas_upshifts" /id="D957" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="4.18195" /MaxDrop="2.2821" /score="0.171090809" /energy="-9.3" /TU="U1410" /idTUdmin="U1408" /TUdmin=2530 /isTUend="FALSE" /label="downshifts" S_feature 1731120..1732216 /Source="Nicolas_S_feature" /locus_tag="new_1900515_1901611" /HighExp="S8, G150, G180, dia0, G135, UNK1, MG 15, Lbexp, Fru, S7" /AntisenseName="cotU" /AntisenseCor="-0.266961200384908" /AntisenseRegPval="-5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S640" S_feature complement(1731175..1731460) /Source="Nicolas_S_feature" /locus_tag="new_1900570_1900855_c" /HighExp="LoTm, dia5, dia15, T3.30H, T3.0H, T-4.40H, T4.0H, T5.0H, T-3.40H, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.25207000000000002" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S641" downshifts complement(1731218) /Source="Nicolas_upshifts" /id="D958" /incds=0 /nref=2 /ntot=95 /MaxReadThrough="4.29622" /MaxDrop="2.9464" /score="11.6697365" /energy="-9.7" /TU="U1411" /idTUdmin="U1411" /TUdmin="-308" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1731455..1731474) /Source="Nicolas_upshift_promotors" /id="U1411" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.96903096903097" /psig="0.997002997002997" /xcortree=3122 /SigmaFactorBS="tatttctttatagagatgcttgtttcatcGACAACtcaatcc taaaTGTGGTAAAATCGATAAAAAtgtaaaaactgtaaatataataaaaggagcatct t" /listShort="S641, S639" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1731460) /Source="Nicolas_upshifts" /id="U1411" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.96903096903097" /psig="0.997002997002997" /xcortree=3122 /SigmaFactorBS="tatttctttatagagatgcttgtttcatcGACAACtcaatcc taaaTGTGGTAAAATCGATAAAAAtgtaaaaactgtaaatataataaaaggagcatct t" /listShort="S641, S639" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1731486..1731491) /Source="Nicolas_upshift_promotors" /id="U1411" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.96903096903097" /psig="0.997002997002997" /xcortree=3122 /SigmaFactorBS="tatttctttatagagatgcttgtttcatcGACAACtcaatcc taaaTGTGGTAAAATCGATAAAAAtgtaaaaactgtaaatataataaaaggagcatct t" /listShort="S641, S639" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(1731722) /Source="Nicolas_upshifts" /id="D959" /incds=0 /nref=17 /ntot=130 /MaxReadThrough="2.07509" /MaxDrop="8.56023" /score="11.6697365" /energy="-9.7" /TU="NA" /idTUdmin="U1412" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(1731722..1731982) /gene="cotU" /locus_tag="BSU_17670" /old_locus_tag="BSU17670" /function="16.8: Protect" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:12562816, 18065538, 20023017" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12562816, 18065538, 20023017; Product type f: factor" /codon_start=1 /transl_table=11 /product="spore coat protein" /protein_id="NP_389650.1" /db_xref="EnsemblGenomes-Gn:BSU17670" /db_xref="EnsemblGenomes-Tr:CAB13651" /db_xref="GOA:O31802" /db_xref="SubtiList:BG13471" /db_xref="UniProtKB/Swiss-Prot:O31802" /translation="MGYYKKYKEEYYTWKKTYYKKYYDNDKKHYDCDKYYDHDKKHYD YDKKYDDHDKKYYDDHDYHYEKKYYDDDDHYYDFVESYKKHH*" /label="cotU CDS" gene complement(1731722..1731982) /gene="cotU" /locus_tag="BSU_17670" /old_locus_tag="BSU17670" /label="cotU gene" promotor_-10 complement(1732003..1732022) /Source="Nicolas_upshift_promotors" /id="U1412" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1427 /SigmaFactorBS="agcctctttttactattcttatttcatttGACCATACCAtat catttaaacTTCATAAATTAAATTCGAATaacataaaggaggaatttaattgggttat t" /listShort="cotU" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1732013) /Source="Nicolas_upshifts" /id="U1412" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1427 /SigmaFactorBS="agcctctttttactattcttatttcatttGACCATACCAtat catttaaacTTCATAAATTAAATTCGAATaacataaaggaggaatttaattgggttat t" /listShort="cotU" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1732035..1732044) /Source="Nicolas_upshift_promotors" /id="U1412" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1427 /SigmaFactorBS="agcctctttttactattcttatttcatttGACCATACCAtat catttaaacTTCATAAATTAAATTCGAATaacataaaggaggaatttaattgggttat t" /listShort="cotU" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1732217..1732342 /gene="ynzJ" /locus_tag="BSU_17678" /old_locus_tag="BSU17678" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein (putative phage origin)" /db_xref="PSEUDO:CAX52624.1" /translation="MNVMVKIQELYDVIFHTAFEGFRVRHQKQTAKPARNRSYKE*" /label="ynzJ CDS" gene 1732217..1732342 /gene="ynzJ" /locus_tag="BSU_17678" /old_locus_tag="BSU17678" /pseudo /label="ynzJ gene" S_feature 1732343..1732459 /Source="Nicolas_S_feature" /locus_tag="new_1901738_1901854" /HighExp="G180, G135, G150, dia0, UNK1, S8, Lbexp, C90, MG 5, MG 150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S642" CDS 1732386..1732550 /locus_tag="BSU_17679" /old_locus_tag="BSU17679" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein from phage origin" /protein_id="YP_009513957.1" /translation="MKLERIYFKESPIAHGQMTIDIEVKYNALNQKKLLEDLMCLDNF QFGIHKHLTI*" /label="conserved hypothetical protein from phage origin CDS" gene 1732386..1732550 /locus_tag="BSU_17679" /old_locus_tag="BSU17679" /label="gene" promotor_-35 1732434..1732443 /Source="Nicolas_upshift_promotors" /id="U1413" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.935064935064935" /psig="0.935064935064935" /xcortree=1261 /SigmaFactorBS="atttattttaaagaaagcccaattgcacatggaCAAATGACA AttgatattgaggtAAAATACAATGCATTAAATCagaaaaagctattggaggatttaa t" /listShort="S643, thyA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1732457..1732476 /Source="Nicolas_upshift_promotors" /id="U1413" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.935064935064935" /psig="0.935064935064935" /xcortree=1261 /SigmaFactorBS="atttattttaaagaaagcccaattgcacatggaCAAATGACA AttgatattgaggtAAAATACAATGCATTAAATCagaaaaagctattggaggatttaa t" /listShort="S643, thyA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1732461..1732771 /Source="Nicolas_S_feature" /locus_tag="new_1901856_1902166" /HighExp="S7, S6, S8, S5, BT, G/S, Pyr, G180, G150, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.585202" /TUshortSig="SigK, SigA" /TUshortPSig="0.935, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S643" upshifts 1732461 /Source="Nicolas_upshifts" /id="U1413" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.935064935064935" /psig="0.935064935064935" /xcortree=1261 /SigmaFactorBS="atttattttaaagaaagcccaattgcacatggaCAAATGACA AttgatattgaggtAAAATACAATGCATTAAATCagaaaaagctattggaggatttaa t" /listShort="S643, thyA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1732752..1732759 /Source="Nicolas_upshift_promotors" /id="U1414" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.916083916083916" /psig="0.99000999000999" /xcortree=1985 /SigmaFactorBS="gagtggaataagatcctcactttatctgcaagtgcttagTAT TTGCGataatattgcattCGTAATAAATTATGCTTAGCaactgaaaatgaaagaagga t" /listShort="thyA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1732773..1732792 /Source="Nicolas_upshift_promotors" /id="U1414" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.916083916083916" /psig="0.99000999000999" /xcortree=1985 /SigmaFactorBS="gagtggaataagatcctcactttatctgcaagtgcttagTAT TTGCGataatattgcattCGTAATAAATTATGCTTAGCaactgaaaatgaaagaagga t" /listShort="thyA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1732773 /Source="Nicolas_upshifts" /id="U1414" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.916083916083916" /psig="0.99000999000999" /xcortree=1985 /SigmaFactorBS="gagtggaataagatcctcactttatctgcaagtgcttagTAT TTGCGataatattgcattCGTAATAAATTATGCTTAGCaactgaaaatgaaagaagga t" /listShort="thyA" /GFF_Attribute="listLong" /label="upshifts" CDS 1732824..1733663 /gene="thyA" /locus_tag="BSU_17680" /old_locus_tag="BSU17680" /EC_number="2.1.1.45" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:416889, 418407, 9648749, 10091656, 10574451" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 416889, 418407, 9648749, 10091656, 10574451; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thymidylate synthase A (phage origin)" /protein_id="NP_389651.1" /db_xref="EnsemblGenomes-Gn:BSU17680" /db_xref="EnsemblGenomes-Tr:CAB13652" /db_xref="GOA:P0CI79" /db_xref="InterPro:IPR000398" /db_xref="InterPro:IPR020940" /db_xref="InterPro:IPR023451" /db_xref="InterPro:IPR036926" /db_xref="PDB:1B02" /db_xref="PDB:1BKO" /db_xref="PDB:1BKP" /db_xref="PDB:1BSF" /db_xref="PDB:1BSP" /db_xref="SubtiList:BG11190" /db_xref="UniProtKB/Swiss-Prot:P0CI79" /translation="MTQFDKQYNSIIKDIINNGISDEEFDVRTKWDSDGTPAHTLSVI SKQMRFDNSEVPILTTKKVAWKTAIKELLWIWQLKSNDVNDLNMMGVHIWDQWKQEDG TIGHAYGFQLGKKNRSLNGEKVDQVDYLLHQLKNNPSSRRHITMLWNPDELDAMALTP CVYETQWYVKHGKLHLEVRARSNDMALGNPFNVFQYNVLQRMIAQVTGYELGEYIFNI GDCHVYTRHIDNLKIQMEREQFEAPELWINPEVKDFYDFTIDDFKLINYKHGDKLLFE VAV*" /label="thyA CDS" gene 1732824..1733663 /gene="thyA" /locus_tag="BSU_17680" /old_locus_tag="BSU17680" /label="thyA gene" promotor_-10 complement(1732846..1732865) /Source="Nicolas_upshift_promotors" /id="U1415" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.651348651348651" /psig="0.982017982017982" /xcortree=3110 /SigmaFactorBS="ccatctgagtcccacttggttcttacatcaaactcttcgtct gaGATTccattattgataatATCCTTTATAATTGAATTGTattgtttatcgaattgcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1732867) /Source="Nicolas_upshifts" /id="U1415" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.651348651348651" /psig="0.982017982017982" /xcortree=3110 /SigmaFactorBS="ccatctgagtcccacttggttcttacatcaaactcttcgtct gaGATTccattattgataatATCCTTTATAATTGAATTGTattgtttatcgaattgcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1732880..1732883) /Source="Nicolas_upshift_promotors" /id="U1415" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.651348651348651" /psig="0.982017982017982" /xcortree=3110 /SigmaFactorBS="ccatctgagtcccacttggttcttacatcaaactcttcgtct gaGATTccattattgataatATCCTTTATAATTGAATTGTattgtttatcgaattgcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1733623 /Source="Nicolas_upshifts" /id="D960" /incds=0 /nref=6 /ntot=143 /MaxReadThrough="4.34299" /MaxDrop="3.3234" /score="1.39203037" /energy="-7.7" /TU="U1410,U1414" /idTUdmin="U1413" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" downshifts complement(1733769) /Source="Nicolas_upshifts" /id="D961" /incds=0 /nref=6 /ntot=150 /MaxReadThrough="3.28185" /MaxDrop="3.73135" /score="3.23768043" /energy="-6.6" /TU="U1417" /idTUdmin="U1417" /TUdmin="-286" /isTUend="FALSE" /label="downshifts" S_feature complement(1733770..1734076) /Source="Nicolas_S_feature" /locus_tag="new_1903165_1903471_c" /HighExp="LBGstat, Lbstat, LoTm, B60, LPhT, M9-stat, T1.30H, B36, nit, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99924299999999999" /TUshortSig="SigA" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S644" CDS complement(1733786..1734073) /locus_tag="BSU_17689" /old_locus_tag="BSU17689" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_009513958.1" /translation="MEHTGHSSFLQLFCLNLTLIRVEIGMKYEKTSLFGMILVIVALL ISIYFMCNTNALIPAGYDLAIHGIVISRTVMIAFTLYLVSKLGYFLLNKKD*" /label="conserved protein of unknown function CDS" gene complement(1733786..1734073) /locus_tag="BSU_17689" /old_locus_tag="BSU17689" /label="gene" downshifts complement(1733813) /Source="Nicolas_upshifts" /id="D962" /incds=0 /nref=2 /ntot=85 /MaxReadThrough="3.82042" /MaxDrop="6.47995" /score="3.23768043" /energy="-6.6" /TU="U1417" /idTUdmin="U1418" /TUdmin=308 /isTUend="FALSE" /label="downshifts" promotor_-35 1733900..1733908 /Source="Nicolas_upshift_promotors" /id="U1416" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=1393 /SigmaFactorBS="tattacaattccatgaatagctagatcatatccagcAGGTAT CAAcgcatttgtattaCACATAAAATATATAGATATtagaagtgctacaataactaaa a" /listShort="S645" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1733922..1733941 /Source="Nicolas_upshift_promotors" /id="U1416" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=1393 /SigmaFactorBS="tattacaattccatgaatagctagatcatatccagcAGGTAT CAAcgcatttgtattaCACATAAAATATATAGATATtagaagtgctacaataactaaa a" /listShort="S645" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1733924 /Source="Nicolas_upshifts" /id="U1416" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=1393 /SigmaFactorBS="tattacaattccatgaatagctagatcatatccagcAGGTAT CAAcgcatttgtattaCACATAAAATATATAGATATtagaagtgctacaataactaaa a" /listShort="S645" /GFF_Attribute="listLong" /label="upshifts" S_feature 1733935..1734095 /Source="Nicolas_S_feature" /locus_tag="new_1903330_1903490" /HighExp="S8, S6, S7, BT, S5, S4, S3, Pyr, G/S, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.98" /TUlongSig="NA" /TUlongPSig="NA" /label="S645" downshifts 1734067 /Source="Nicolas_upshifts" /id="D963" /incds=0 /nref=13 /ntot=53 /MaxReadThrough="1.26429" /MaxDrop="5.75919" /score="7.35184753" /energy="-11.1" /TU="NA" /idTUdmin="U1416" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1734116..1734838) /gene="yncM" /locus_tag="BSU_17690" /old_locus_tag="BSU17690" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences" /codon_start=1 /transl_table=11 /product="conserved exported protein" /protein_id="NP_389652.2" /db_xref="EnsemblGenomes-Gn:BSU17690" /db_xref="EnsemblGenomes-Tr:CAB13653" /db_xref="GOA:O31803" /db_xref="InterPro:IPR029143" /db_xref="PDB:4HFS" /db_xref="SubtiList:BG13438" /db_xref="UniProtKB/Swiss-Prot:O31803" /translation="MVKKVLIAGAVGTAVLFGTLSSGIPGLPAADAQVAKAASELPNG IGGRVYLNSTGAVFTAKIVLPETVKNNDSVSTPYIYSGFRATSGTEADIGLQYSKQYN VWKPLMKVGSKNEETYIEGKDKFTYNKGFRPGSTVQMTIYKNLSGNTRMTLWGTNNDG YTGRIITEIQGTNIGTISKWKTLATAAVSYESQRDAIKATFSTSFNNITIDNKAVTPV VDTQDFAKVSVAGNNVTISVNK*" /label="yncM CDS" gene complement(1734116..1734838) /gene="yncM" /locus_tag="BSU_17690" /old_locus_tag="BSU17690" /label="yncM gene" downshifts complement(1734121) /Source="Nicolas_upshifts" /id="D964" /incds=0 /nref=31 /ntot=133 /MaxReadThrough="5.62856" /MaxDrop="4.3658" /score="0.425084384" /energy="-11.1" /TU="U1417" /idTUdmin="U1418" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(1734863..1734882) /Source="Nicolas_upshift_promotors" /id="U1417" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.51048951048951" /psig="0.994005994005994" /xcortree=503 /SigmaFactorBS="ttcaaaatgaaatattttgtcgatttatatacgtaaatccag ttccaaaATAAGGTATAATAAATGGCGaaaccactatcaaaagggggaattttggtga a" /listShort="yncM, S644" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1734871) /Source="Nicolas_upshifts" /id="U1417" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.51048951048951" /psig="0.994005994005994" /xcortree=503 /SigmaFactorBS="ttcaaaatgaaatattttgtcgatttatatacgtaaatccag ttccaaaATAAGGTATAATAAATGGCGaaaccactatcaaaagggggaattttggtga a" /listShort="yncM, S644" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1734873..1734997) /Source="Nicolas_S_feature" /locus_tag="new_1904268_1904392_c" /HighExp="H2O2, dia15, S8, G180, G150, Paraq, Oxctl, LBGstat, G135, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S646" CDS complement(1734998..1735354) /gene="ynzK" /locus_tag="BSU_17699" /old_locus_tag="BSU17699" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein of unknown function (phage origin)" /protein_id="YP_003097731.1" /db_xref="EnsemblGenomes-Gn:BSU17699" /db_xref="EnsemblGenomes-Tr:CAX52625" /db_xref="GOA:C0H417" /db_xref="InterPro:IPR025621" /db_xref="UniProtKB/Swiss-Prot:C0H417" /translation="MYRNIVFYLILLCLFISVVMKSFEVIRTIANVICFIFVLLYFKD EMKTYSRKALAILSICFLFLVGICAFIILQGQTLMKRHLFFTGLETIAGILLIIVSLS ICTFILRKISNRLKRM*" /label="ynzK CDS" gene complement(1734998..1735354) /gene="ynzK" /locus_tag="BSU_17699" /old_locus_tag="BSU17699" /label="ynzK gene" promotor_-10 complement(1735378..1735397) /Source="Nicolas_upshift_promotors" /id="U1418" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=1838 /SigmaFactorBS="acatagtttagttagttcataagtgagcgcattcaattTATT GcagttacaaagaaacTTTTATAAACTCTTTGAGGAtcctacataaaaggagaggttt t" /listShort="ynzK, S646, yncM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1735395) /Source="Nicolas_upshifts" /id="U1418" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=1838 /SigmaFactorBS="acatagtttagttagttcataagtgagcgcattcaattTATT GcagttacaaagaaacTTTTATAAACTCTTTGAGGAtcctacataaaaggagaggttt t" /listShort="ynzK, S646, yncM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1735413..1735417) /Source="Nicolas_upshift_promotors" /id="U1418" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=1838 /SigmaFactorBS="acatagtttagttagttcataagtgagcgcattcaattTATT GcagttacaaagaaacTTTTATAAACTCTTTGAGGAtcctacataaaaggagaggttt t" /listShort="ynzK, S646, yncM" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(1735594) /Source="Nicolas_upshifts" /id="D965" /incds=0 /nref=58 /ntot=194 /MaxReadThrough="0.902090000000001" /MaxDrop="9.00312" /score="34.0680178" /energy="-10.8" /TU="NA" /idTUdmin="U1419" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" CDS complement(1735600..1735800) /gene="cotC" /locus_tag="BSU_17700" /old_locus_tag="BSU17700" /function="16.8: Protect" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10788508, 11741866, 14762008, 18065538, 2821284, 19933362, 20023017" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10788508, 11741866, 14762008, 18065538, 2821284, 19933362, 20023017; Product type s: structure" /codon_start=1 /transl_table=11 /product="spore coat protein (outer)" /protein_id="NP_389653.2" /db_xref="EnsemblGenomes-Gn:BSU17700" /db_xref="EnsemblGenomes-Tr:CAB13654" /db_xref="GOA:P07790" /db_xref="SubtiList:BG10492" /db_xref="UniProtKB/Swiss-Prot:P07790" /translation="MGYYKKYKEEYYTVKKTYYKKYYEYDKKDYDCDYDKKYDDYDKK YYDHDKKDYDYVVEYKKHKKHY*" /label="cotC CDS" gene complement(1735600..1735800) /gene="cotC" /locus_tag="BSU_17700" /old_locus_tag="BSU17700" /label="cotC gene" downshifts 1735783 /Source="Nicolas_upshifts" /id="D966" /incds=0 /nref=14 /ntot=29 /MaxReadThrough="1.37504" /MaxDrop="5.08099" /score="-4.2739983" /energy="-8" /TU="NA" /idTUdmin="U1416" /TUdmin=1716 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1735822..1735841) /Source="Nicolas_upshift_promotors" /id="U1419" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=1429 /SigmaFactorBS="acagcccttttttccttctatgattttaactGTCCAAGCCGc aaaatctactcGCCGTATAATAAAGCGTAGTaaaaataaaggaggagtatatatgggt t" /listShort="cotC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1735834) /Source="Nicolas_upshifts" /id="U1419" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=1429 /SigmaFactorBS="acagcccttttttccttctatgattttaactGTCCAAGCCGc aaaatctactcGCCGTATAATAAAGCGTAGTaaaaataaaggaggagtatatatgggt t" /listShort="cotC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1735854..1735863) /Source="Nicolas_upshift_promotors" /id="U1419" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=1429 /SigmaFactorBS="acagcccttttttccttctatgattttaactGTCCAAGCCGc aaaatctactcGCCGTATAATAAAGCGTAGTaaaaataaaggaggagtatatatgggt t" /listShort="cotC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1735975..1736163) /gene="tatAC" /locus_tag="BSU_17710" /old_locus_tag="BSU17710" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10974125, 11007775, 26239117" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10974125, 11007775, 26239117; Product type t: transporter" /codon_start=1 /transl_table=11 /product="component of the twin-arginine pre-protein translocation pathway" /protein_id="NP_389654.1" /db_xref="EnsemblGenomes-Gn:BSU17710" /db_xref="EnsemblGenomes-Tr:CAB13655" /db_xref="GOA:O31804" /db_xref="InterPro:IPR003369" /db_xref="InterPro:IPR006312" /db_xref="SubtiList:BG13464" /db_xref="UniProtKB/Swiss-Prot:O31804" /translation="MELSFTKILVILFVGFLVFGPDKLPALGRAAGKALSEFKQATSG LTQDIRKNDSENKEDKQM*" /label="tatAC CDS" gene complement(1735975..1736163) /gene="tatAC" /locus_tag="BSU_17710" /old_locus_tag="BSU17710" /label="tatAC gene" downshifts complement(1735991) /Source="Nicolas_upshifts" /id="D967" /incds=0 /nref=213 /ntot=254 /MaxReadThrough="3.38696" /MaxDrop="6.07983" /score="8.58114058" /energy="-11" /TU="U1420,U1421" /idTUdmin="U1420" /TUdmin="-374" /isTUend="FALSE" /label="downshifts" misc_feature complement(1736132..1736139) /Source="Nicolas_upshift_promotors" /id="U1420" /multdbtbs="-" /comp="M1" /sig="Sig-" /pcomp="0.405594405594406" /psig="0.405594405594406" /xcortree=1585 /SigmaFactorBS="aatttgtttaaaaggttgtacttcaatcagggggaaaaggat atggaattaagcttcacaaaaataCTCGTTATtttgtttgtgggttttttagtatttg g" /listShort="tatAC, cotC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1736145) /Source="Nicolas_upshifts" /id="U1420" /multdbtbs="-" /comp="M1" /sig="Sig-" /pcomp="0.405594405594406" /psig="0.405594405594406" /xcortree=1585 /SigmaFactorBS="aatttgtttaaaaggttgtacttcaatcagggggaaaaggat atggaattaagcttcacaaaaataCTCGTTATtttgtttgtgggttttttagtatttg g" /listShort="tatAC, cotC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1736192..1736211) /Source="Nicolas_upshift_promotors" /id="U1421" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=488 /SigmaFactorBS="cgtctttgtgctggttttaaaatgttcaaaataaatgCATTC CCAtttgtactgctatcTCTTATAATTTGTTTAAAAGgttgtacttcaatcaggggga a" /listShort="tatAC, cotC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1736210) /Source="Nicolas_upshifts" /id="U1421" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=488 /SigmaFactorBS="cgtctttgtgctggttttaaaatgttcaaaataaatgCATTC CCAtttgtactgctatcTCTTATAATTTGTTTAAAAGgttgtacttcaatcaggggga a" /listShort="tatAC, cotC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1736226..1736233) /Source="Nicolas_upshift_promotors" /id="U1421" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=488 /SigmaFactorBS="cgtctttgtgctggttttaaaatgttcaaaataaatgCATTC CCAtttgtactgctatcTCTTATAATTTGTTTAAAAGgttgtacttcaatcaggggga a" /listShort="tatAC, cotC" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1736242..1736379 /locus_tag="BSU_17715" /old_locus_tag="BSU17715" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513959.1" /translation="MNILKPAQRRIHKTAAAEYNVQCHLPKKQEAGWINYVALPEMIQ T*" /label="hypothetical protein CDS" gene 1736242..1736379 /locus_tag="BSU_17715" /old_locus_tag="BSU17715" /label="gene" promotor_-35 1736273..1736278 /Source="Nicolas_upshift_promotors" /id="U1422" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1117 /SigmaFactorBS="ttaaaaccagcacaaagacggaTTCATAaaacggctgctgct GAATATAATGTCCAATGCCacctgcctaagaagcaggaggcaggctggatcaattatg t" /listShort="S647, yndA, S648, ynzB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1736293..1736311 /Source="Nicolas_upshift_promotors" /id="U1422" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1117 /SigmaFactorBS="ttaaaaccagcacaaagacggaTTCATAaaacggctgctgct GAATATAATGTCCAATGCCacctgcctaagaagcaggaggcaggctggatcaattatg t" /listShort="S647, yndA, S648, ynzB" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1736311..1736413 /Source="Nicolas_S_feature" /locus_tag="new_1905706_1905808" /HighExp="S3, S4, LoTm, BT, B36, S5, S7, S6, T5.0H, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.35884500000000003" /TUshortSig="SigEF" /TUshortPSig="0.983" /TUlongSig="NA" /TUlongPSig="NA" /label="S647" upshifts 1736311 /Source="Nicolas_upshifts" /id="U1422" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1117 /SigmaFactorBS="ttaaaaccagcacaaagacggaTTCATAaaacggctgctgct GAATATAATGTCCAATGCCacctgcctaagaagcaggaggcaggctggatcaattatg t" /listShort="S647, yndA, S648, ynzB" /GFF_Attribute="listLong" /label="upshifts" CDS 1736414..1736812 /gene="yndA" /locus_tag="BSU_17720" /old_locus_tag="BSU17720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="putative exported protein of unknown function" /protein_id="NP_389655.1" /db_xref="EnsemblGenomes-Gn:BSU17720" /db_xref="EnsemblGenomes-Tr:CAB13656" /db_xref="SubtiList:BG13439" /db_xref="UniProtKB/Swiss-Prot:O31805" /translation="MRFTKVVGFLSVLGLAAVFPLTAQAEKAGTAGAGEWDKLGTYTY TYSSPTVYSTGGDFRVCLSGSTPFSVSLHLYEDDPGDNPDDYVGANYFSPGECHTFGS IGKFVDGSNNKAEFFVTDYSGKSKTVTFYD*" /label="yndA CDS" gene 1736414..1736812 /gene="yndA" /locus_tag="BSU_17720" /old_locus_tag="BSU17720" /label="yndA gene" S_feature 1736813..1737617 /Source="Nicolas_S_feature" /locus_tag="new_1906208_1907012" /HighExp="LoTm, S3, BT, S4, B36, S6, S5, S7, S8, T5.0H" /AntisenseName="yndB" /AntisenseCor="-0.559713635360228" /AntisenseRegPval="-22.9" /CDS_PredictionProba="0.91098199999999996" /TUshortSig="SigEF" /TUshortPSig="0.983" /TUlongSig="NA" /TUlongPSig="NA" /label="S648" CDS complement(1736877..1737311) /gene="flvS" /locus_tag="BSU_17730" /old_locus_tag="BSU17730" /experiment="publication(s) with functional evidences, PMID:20818668, 28160315" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20818668, 28160315; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of stress-related ATPase (flavonoid-sensing)" /protein_id="NP_389656.1" /db_xref="EnsemblGenomes-Gn:BSU17730" /db_xref="EnsemblGenomes-Tr:CAB13657" /db_xref="GOA:O31806" /db_xref="InterPro:IPR013538" /db_xref="InterPro:IPR023393" /db_xref="PDB:2KEW" /db_xref="PDB:2KTE" /db_xref="SubtiList:BG13440" /db_xref="UniProtKB/Swiss-Prot:O31806" /translation="MAQNNENALPDITKSITLEAPIQKVWETVSTSEGIAKWFMPNDF QLKEGQEFHLQSPFGPSPCKVLAVQAPTELSFEWDTEGWVVTFQLEDLGEKTGFTLIH SGWKEPNEVIGKANEKSSVVRGKMDGGWTGIVNERLRKAVEE*" /label="flvS CDS" gene complement(1736877..1737311) /gene="flvS" /locus_tag="BSU_17730" /old_locus_tag="BSU17730" /label="flvS gene" downshifts complement(1736893) /Source="Nicolas_upshifts" /id="D968" /incds=0 /nref=213 /ntot=253 /MaxReadThrough="1.7995" /MaxDrop="6.63594" /score="29.1580701" /energy="-7" /TU="NA" /idTUdmin="U1423" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1737341..1737360) /Source="Nicolas_upshift_promotors" /id="U1423" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.487512487512487" /psig="0.996003996003996" /xcortree=2282 /SigmaFactorBS="ctgttcaacagcagctctagcataaataatgcacgcTATGGA CAtgatcttattagtTATTATATGATTGAATTGAAaaaacatcatatgtcaagaggta a" /listShort="yndB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1737357) /Source="Nicolas_upshifts" /id="U1423" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.487512487512487" /psig="0.996003996003996" /xcortree=2282 /SigmaFactorBS="ctgttcaacagcagctctagcataaataatgcacgcTATGGA CAtgatcttattagtTATTATATGATTGAATTGAAaaaacatcatatgtcaagaggta a" /listShort="yndB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1737374..1737381) /Source="Nicolas_upshift_promotors" /id="U1423" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.487512487512487" /psig="0.996003996003996" /xcortree=2282 /SigmaFactorBS="ctgttcaacagcagctctagcataaataatgcacgcTATGGA CAtgatcttattagtTATTATATGATTGAATTGAAaaaacatcatatgtcaagaggta a" /listShort="yndB" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1737618..1737806 /gene="ynzB" /locus_tag="BSU_17740" /old_locus_tag="BSU17740" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23625846" /codon_start=1 /transl_table=11 /product="conserved protein involved in spore germination" /protein_id="NP_389657.2" /db_xref="EnsemblGenomes-Gn:BSU17740" /db_xref="EnsemblGenomes-Tr:CAB13658" /db_xref="SubtiList:BG13465" /db_xref="UniProtKB/Swiss-Prot:O31807" /translation="MLGKIKAAIDNSPGKPARILVSEKAFQQLEEEMRFVYVSKPKTI MGIPVEVSDQAESFKLEF*" /label="ynzB CDS" gene 1737618..1737806 /gene="ynzB" /locus_tag="BSU_17740" /old_locus_tag="BSU17740" /label="ynzB gene" S_feature 1737807..1737892 /Source="Nicolas_S_feature" /locus_tag="new_1907202_1907287" /HighExp="LoTm, BT, S4, S6, S3, S8, S7, B36, S5, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S649" downshifts 1737851 /Source="Nicolas_upshifts" /id="D969" /incds=0 /nref=7 /ntot=89 /MaxReadThrough="2.20002" /MaxDrop="4.21414" /score="19.5879917" /energy="-11.9" /TU="NA" /idTUdmin="U1422" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1737921..1737927 /Source="Nicolas_upshift_promotors" /id="U1424" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=875 /SigmaFactorBS="tgatgaaatgttcatcatgcttttttattgagaaaaaagacg AACATAAaaaataggtatacGGGAAAAATAATcctattagagagaggggaactgacag a" /listShort="S650, yndD" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1737939..1738098 /Source="Nicolas_S_feature" /locus_tag="new_1907334_1907493" /HighExp="S8, S4, S6, S7, S5, S3, BT, ferm, LoTm, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.95681300000000002" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S650" upshifts 1737939 /Source="Nicolas_upshifts" /id="U1424" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=875 /SigmaFactorBS="tgatgaaatgttcatcatgcttttttattgagaaaaaagacg AACATAAaaaataggtatacGGGAAAAATAATcctattagagagaggggaactgacag a" /listShort="S650, yndD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1737941..1737952 /Source="Nicolas_upshift_promotors" /id="U1424" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=875 /SigmaFactorBS="tgatgaaatgttcatcatgcttttttattgagaaaaaagacg AACATAAaaaataggtatacGGGAAAAATAATcctattagagagaggggaactgacag a" /listShort="S650, yndD" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1738099..1739661 /gene="yndD" /locus_tag="BSU_17750" /old_locus_tag="BSU17750" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 10762253, 27208128; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination receptor subunit" /protein_id="NP_389658.1" /db_xref="EnsemblGenomes-Gn:BSU17750" /db_xref="EnsemblGenomes-Tr:CAB13659" /db_xref="GOA:O31808" /db_xref="InterPro:IPR004995" /db_xref="SubtiList:BG13441" /db_xref="UniProtKB/Swiss-Prot:O31808" /translation="MMRWRNNQYKTQKQHKSDYSTAEKQDQDVLTGNIGYDLEHVKRK IGHNGDVHFRELEITQLHVKAALIFVEGLSDQDLINKGLSVLVMNQPNQVSDEISQSG KGILTSKQIKNQIVSIGDVIDSEKISDIVLNVFMGSTALLIDGIPQAFLLGTVKKQNR SIEEPLSEALVRGPRTGFTEELSTNTALLRQQGKNDQLTLQRFEVGTRLKKDLIIAYM NDIADPKVVEEVRKRVRGIEIDHLPESGYVEQLIEDNYLSPFPQVQSTERPDRVISGL MEGRVAILLDGTPFALIVPVTFSMMLQSPEDYYERWFPSSLIRLLRFIAAMITLFAPA LYISFISFHPGLIPTKLAISISGTRQGVPFPSLIEALFMEVAIEILREAGLRLPKPIG PAIGIVGGLIIGEAAVQAGIVSPIMVIVVALTAISSFAIPHYSTGIALRMLRFGAMFC AAVFGLFGVIMYYLLLSSHVVKLKSFGVPYASPAVPYHLKDWKDFVIRMPLLVMKRRP KMMNTDNTKRVK*" /label="yndD CDS" gene 1738099..1739661 /gene="yndD" /locus_tag="BSU_17750" /old_locus_tag="BSU17750" /label="yndD gene" promotor_-10 complement(1738402..1738421) /Source="Nicolas_upshift_promotors" /id="U1425" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.952047952047952" /psig="0.982017982017982" /xcortree=2029 /SigmaFactorBS="ctgaatctatgacatcaccgattgatacGATTTGATttttta tctgtttcGAAGTTAAAATACCTTTGCCggattgagaaatttcatcgcttacctgatt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1738411) /Source="Nicolas_upshifts" /id="U1425" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.952047952047952" /psig="0.982017982017982" /xcortree=2029 /SigmaFactorBS="ctgaatctatgacatcaccgattgatacGATTTGATttttta tctgtttcGAAGTTAAAATACCTTTGCCggattgagaaatttcatcgcttacctgatt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1738436..1738443) /Source="Nicolas_upshift_promotors" /id="U1425" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.952047952047952" /psig="0.982017982017982" /xcortree=2029 /SigmaFactorBS="ctgaatctatgacatcaccgattgatacGATTTGATttttta tctgtttcGAAGTTAAAATACCTTTGCCggattgagaaatttcatcgcttacctgatt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1739691..1740782 /gene="yndE" /locus_tag="BSU_17760" /old_locus_tag="BSU17760" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10762253, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative spore germination integral inner membrane protein" /protein_id="NP_389659.1" /db_xref="EnsemblGenomes-Gn:BSU17760" /db_xref="EnsemblGenomes-Tr:CAB13660" /db_xref="GOA:O31809" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004761" /db_xref="SubtiList:BG13442" /db_xref="UniProtKB/Swiss-Prot:O31809" /translation="MFSPTSKITTAQATIIIINYMLAAGVLTLPRTVTEQTQSPDGWI SVLLGGVLAVIAGMIIAKLSQQYPKETFYEYSRHIVGKWLGHLISIVFITYFLALGAF EVRVMSEIVDFFLLEGTPSWAIIMTVLWIGLYSITQGLDPIARLFEMIFPITVIIFLT IALMSLGIFEINNLRPVLGDGIMPVLRGVKTTNLSFTCSEIMFILVAFMKKPKNAVKA VVIGTGVVTSFYMITMIMVIGALSVEGVVTRTWPGLDLMRSFEIPGLIFERFESFLLV IWIMQLFATFIITFYAASLGVSQVFKKKPLSCMFGLLPVIYILSCMPKNENDVFILGD TVSHIALYIFGALPILLLVISKWRKRGEK*" /label="yndE CDS" gene 1739691..1740782 /gene="yndE" /locus_tag="BSU_17760" /old_locus_tag="BSU17760" /label="yndE gene" CDS 1740772..1741986 /gene="yndF" /locus_tag="BSU_17770" /old_locus_tag="BSU17770" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10762253, 27208128; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative spore germination lipoprotein" /protein_id="NP_389660.1" /db_xref="EnsemblGenomes-Gn:BSU17770" /db_xref="EnsemblGenomes-Tr:CAB13661" /db_xref="GOA:O31810" /db_xref="InterPro:IPR008844" /db_xref="SubtiList:BG13443" /db_xref="UniProtKB/Swiss-Prot:O31810" /translation="MKSKLKRQLPAMVIVCLLMICVTGCWSSREIEDLGLTFAIAIDK GKETNTEKELKEEGGSYPKKDNITLTYQFVNEKAAGAGTSGGGGSGQGAQKAYINISE TGDSLQQIGSEVALRRDREVFSPHLKVVVMSEDVLHTFPIDEMLDQFFRDNEIRLSCL VLSAKGEARDALQLKENGEIPAFRLIGLGENEHKVSRILPPMTLAKLIGKLHSGSSFL LQNVVAANGAVKYSGAAVINGKSKKMIGTLNEYETEGITWIRGEGKGGVVKSHDKKSQ QTLAYDINKIKSRIQPIVKGKDISFHVDIESEGDLVENWNTKEALDTQFIDRLETTIE NEVKKIVGQVLKKIQHDYKADVAGFDESFRLTYPHLWKRVKNNWDDTFSKADITYSVN VTITHFGTVKTQ*" /label="yndF CDS" gene 1740772..1741986 /gene="yndF" /locus_tag="BSU_17770" /old_locus_tag="BSU17770" /label="yndF gene" promotor_-35 1742064..1742071 /Source="Nicolas_upshift_promotors" /id="U1426" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.534465534465534" /psig="0.98001998001998" /xcortree=2419 /SigmaFactorBS="ttaggataaagatactttttttggagaGATATACActtttca aatcgacCAATATGCTAATATAGGAATtgcttgaaatagaagggagaaggggctgtga g" /listShort="yndG, yndH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1742086..1742105 /Source="Nicolas_upshift_promotors" /id="U1426" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.534465534465534" /psig="0.98001998001998" /xcortree=2419 /SigmaFactorBS="ttaggataaagatactttttttggagaGATATACActtttca aatcgacCAATATGCTAATATAGGAATtgcttgaaatagaagggagaaggggctgtga g" /listShort="yndG, yndH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1742097 /Source="Nicolas_upshifts" /id="U1426" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.534465534465534" /psig="0.98001998001998" /xcortree=2419 /SigmaFactorBS="ttaggataaagatactttttttggagaGATATACActtttca aatcgacCAATATGCTAATATAGGAATtgcttgaaatagaagggagaaggggctgtga g" /listShort="yndG, yndH" /GFF_Attribute="listLong" /label="upshifts" CDS 1742133..1742939 /gene="yndG" /locus_tag="BSU_17780" /old_locus_tag="BSU17780" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11737947, 22333191, 27435445" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389661.1" /db_xref="EnsemblGenomes-Gn:BSU17780" /db_xref="EnsemblGenomes-Tr:CAB13662" /db_xref="GOA:O31811" /db_xref="SubtiList:BG13444" /db_xref="UniProtKB/Swiss-Prot:O31811" /translation="MRQKPIYVEIEMKSDLDTLWEYTQNPSLHKEWDLRFSNITYLNS QPCEKQKFLYETRVGFGLKVSGTGETVGVFNKCSSERSSSLAFGSDHPLSLIRHGSGY WKYIQRENGKMTFLTQYQYKTAYGLLGRWIDRLLFRPLLGWATAWSFDALRLWVEQNK HPKRFIRSAIIYVFMCLFFSLFWFYQGFAGVKTSILTGTAEIGLAILWLLPLKRKWII HGVQACIFAGFACLGSEIFMWVLLSVFSAASGALSLQLPSARRTKRKRKK*" /label="yndG CDS" gene 1742133..1742939 /gene="yndG" /locus_tag="BSU_17780" /old_locus_tag="BSU17780" /label="yndG gene" S_feature complement(1742747..1743845) /Source="Nicolas_S_feature" /locus_tag="new_1912142_1913240_c" /HighExp="S8, S6, S7, S5, T0.30H, T2.0H, GM 150, BT, T1.30H, T-4.40H" /AntisenseName="yndH" /AntisenseCor="-0.58089150558713998" /AntisenseRegPval="-24.9" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.989" /TUlongSig="NA" /TUlongPSig="NA" /label="S651" CDS 1742944..1743561 /gene="yndH" /locus_tag="BSU_17790" /old_locus_tag="BSU17790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389662.1" /db_xref="EnsemblGenomes-Gn:BSU17790" /db_xref="EnsemblGenomes-Tr:CAB13663" /db_xref="InterPro:IPR025311" /db_xref="SubtiList:BG13445" /db_xref="UniProtKB/Swiss-Prot:O31812" /translation="MSSIYEKSIINYHLLHPKLQKRYQLDGSHTFSGTGTMSEISGGS FLVRMLLKLGVFFRCFFSERGKDIPFTIQNRTCLLKSQHTGIEWNRTFFFKGKKRFFD ALMIYDEKENRILDFFGKPHLLLSVLTFEASLDGSLTITSGKQWLLICGKRIPLPKWL TGTSEVCETFDEKKNCFTIEVHVQNTILGTLFFYKGTFQEEERES*" /label="yndH CDS" gene 1742944..1743561 /gene="yndH" /locus_tag="BSU_17790" /old_locus_tag="BSU17790" /label="yndH gene" CDS 1743558..1745198 /gene="yndJ" /locus_tag="BSU_17800" /old_locus_tag="BSU17800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12618455, 15849754, 16850406, 28615734; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_389663.1" /db_xref="EnsemblGenomes-Gn:BSU17800" /db_xref="EnsemblGenomes-Tr:CAB13664" /db_xref="GOA:O31813" /db_xref="InterPro:IPR025450" /db_xref="SubtiList:BG13446" /db_xref="UniProtKB/Swiss-Prot:O31813" /translation="MKRNGIVSALCFIGFLAAEAPDISVAEALVLLSILFFVPGIFPF VFRQSPVRAAQFMENGLIQCYPVAAFFAVLALVTEVGGFALIWWMYTVFNALYAILRL WETKIHRIEETSVLFGLIYLAGGGFWFFAYAAHLQIMQFGPLIILLTAVHFHYSAFLI PIFNGLLGRTIRKHRMLYSWITWVILLSPLLIALGITYSKTLDVIAVSIYMAAIYLHA FLVFTAAFRTKTGTFLIRLSSAVLMITIAFSMIYSFGVFRQEVTLTINQMIWIHGFVN AFGVILPALIGWRIEDAKPFDADSVKTFSRIYGKRKIGEEFLANIQAENNARYSGLVD DMGSLRSKDFSPEKLAPLILSFYEQTIEYNIKAKVTWSTWFRPLAIIYEWFSRRIGQI HLSTNPDWYRMYSKIKGVHSKKDGRERVRAWIRTNEKNETIFTALYSVYRSNGEGYMN ISLPLPFSSMTGILKPYHHQEKLVLTSRRRKSRAGDEGIYLQTRAGTCPLPLSETFLI EAVHDNKLTAVHHMWLFGIKFLTVHYSITHINQPIERT*" /label="yndJ CDS" gene 1743558..1745198 /gene="yndJ" /locus_tag="BSU_17800" /old_locus_tag="BSU17800" /label="yndJ gene" promotor_-10 complement(1743832..1743851) /Source="Nicolas_upshift_promotors" /id="U1427" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=1248 /SigmaFactorBS="caaaactgatgtctcttcgattctatgtatctTTGTTTCCCa aaggcggaggatCGCATACAATGCATTAAAAActgtgtacatccaccagataagtgcg a" /listShort="S651" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1743845) /Source="Nicolas_upshifts" /id="U1427" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=1248 /SigmaFactorBS="caaaactgatgtctcttcgattctatgtatctTTGTTTCCCa aaggcggaggatCGCATACAATGCATTAAAAActgtgtacatccaccagataagtgcg a" /listShort="S651" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1743865..1743873) /Source="Nicolas_upshift_promotors" /id="U1427" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=1248 /SigmaFactorBS="caaaactgatgtctcttcgattctatgtatctTTGTTTCCCa aaggcggaggatCGCATACAATGCATTAAAAActgtgtacatccaccagataagtgcg a" /listShort="S651" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(1744838..1745604) /Source="Nicolas_S_feature" /locus_tag="new_1914233_1914999_c" /HighExp="T2.0H, T1.30H, T2.30H, GM 150, T3.30H, T1.0H, C30, T3.0H, T4.0H, T0.30H" /AntisenseName="yndK" /AntisenseCor="-0.33555507319526101" /AntisenseRegPval="-7.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S652" CDS 1745235..1745600 /gene="yndK" /locus_tag="BSU_17810" /old_locus_tag="BSU17810" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative phage/plasmid replication protein" /protein_id="NP_389664.1" /db_xref="EnsemblGenomes-Gn:BSU17810" /db_xref="EnsemblGenomes-Tr:CAB13665" /db_xref="GOA:O31814" /db_xref="SubtiList:BG13447" /db_xref="UniProtKB/Swiss-Prot:O31814" /translation="MNCFKILHRIKTGKEGFMVFYISLFLILWLAAGFAVGMKQVYVD QLFDKAVIERLEKEANDHGHADRMIKQRVLYIAAVTVSGFISVYYEMKTIPQRRNIRK IEKNIMKLNQAKKRRMKRK*" /label="yndK CDS" gene 1745235..1745600 /gene="yndK" /locus_tag="BSU_17810" /old_locus_tag="BSU17810" /label="yndK gene" downshifts 1745577 /Source="Nicolas_upshifts" /id="D970" /incds=0 /nref=166 /ntot=243 /MaxReadThrough="2.62352" /MaxDrop="5.68917" /score="15.340233" /energy="-10.4" /TU="NA" /idTUdmin="U1426" /TUdmin=2226 /isTUend="FALSE" /label="downshifts" misc_RNA complement(1745597..1745877) /gene="surA" /locus_tag="BSU_misc_RNA_72" /product="small untranslated RNA controlled by sporulation" /experiment="publication(s) with functional evidences, PMID:16385044" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16385044; Product type n: RNA" /label="surA RNA" gene complement(1745597..1745877) /gene="surA" /locus_tag="BSU_misc_RNA_72" /label="surA gene" S_feature complement(1745606..1745737) /Source="Nicolas_S_feature" /locus_tag="new_1915001_1915132_c" /HighExp="B60, T2.0H, T1.30H, T1.0H, T2.30H, M9-stat, LoTm, S5, T3.30H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.443, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S653" downshifts complement(1745649) /Source="Nicolas_upshifts" /id="D971" /incds=0 /nref=21 /ntot=129 /MaxReadThrough="4.91485" /MaxDrop="4.94426" /score="14.7738511" /energy="-10.4" /TU="U1429,U1431" /idTUdmin="U1429" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" promotor_-35 1745697..1745706 /Source="Nicolas_upshift_promotors" /id="U1428" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.934065934065934" /psig="0.934065934065934" /xcortree=1253 /SigmaFactorBS="agcttacttttcataaattcaaaaatgagaagAACAGCGCCC gggctaatggtatATAATATTGTGAATTTAACAaaaatttaacaaggaggacgagaga a" /listShort="S654, yndL, S657, fosB, S658, S659" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(1745719..1745728) /Source="Nicolas_upshift_promotors" /id="U1429" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.442557442557443" /psig="0.442557442557443" /xcortree=1043 /SigmaFactorBS="gaatgtaggtctctttgaggctttagcacgaattctctcgtc ctccttgttaaatttttgttaaattcaCAATATTATAtaccattagcccgggcgctgt t" /listShort="S653" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 1745720..1745739 /Source="Nicolas_upshift_promotors" /id="U1428" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.934065934065934" /psig="0.934065934065934" /xcortree=1253 /SigmaFactorBS="agcttacttttcataaattcaaaaatgagaagAACAGCGCCC gggctaatggtatATAATATTGTGAATTTAACAaaaatttaacaaggaggacgagaga a" /listShort="S654, yndL, S657, fosB, S658, S659" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1745725 /Source="Nicolas_upshifts" /id="U1428" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.934065934065934" /psig="0.934065934065934" /xcortree=1253 /SigmaFactorBS="agcttacttttcataaattcaaaaatgagaagAACAGCGCCC gggctaatggtatATAATATTGTGAATTTAACAaaaatttaacaaggaggacgagaga a" /listShort="S654, yndL, S657, fosB, S658, S659" /GFF_Attribute="listLong" /label="upshifts" S_feature 1745727..1745825 /Source="Nicolas_S_feature" /locus_tag="new_1915122_1915220" /HighExp="S8, S6, S7, BT, S5, G/S, B36, C30, Pyr, UNK1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.52117199999999997" /TUshortSig="SigK" /TUshortPSig="0.934" /TUlongSig="NA" /TUlongPSig="NA" /label="S654" upshifts complement(1745737) /Source="Nicolas_upshifts" /id="U1429" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.442557442557443" /psig="0.442557442557443" /xcortree=1043 /SigmaFactorBS="gaatgtaggtctctttgaggctttagcacgaattctctcgtc ctccttgttaaatttttgttaaattcaCAATATTATAtaccattagcccgggcgctgt t" /listShort="S653" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1745739..1745869) /Source="Nicolas_S_feature" /locus_tag="new_1915134_1915264_c" /HighExp="T2.0H, T1.30H, M9-stat, T2.30H, T1.0H, B60, LoTm, T4.0H, T3.30H, T0.30H" /AntisenseName="yndL" /AntisenseCor="0.22331158442510801" /AntisenseRegPval="-3.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S655" CDS 1745826..1746584 /gene="pghL" /locus_tag="BSU_17820" /old_locus_tag="BSU17820" /EC_number="3.4.19.-" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:26158264" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 26158264; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="phage gamma-polyglutamate hydrolase" /protein_id="NP_389665.1" /db_xref="EnsemblGenomes-Gn:BSU17820" /db_xref="EnsemblGenomes-Tr:CAB13666" /db_xref="GOA:O31815" /db_xref="InterPro:IPR008585" /db_xref="SubtiList:BG13448" /db_xref="UniProtKB/Swiss-Prot:O31815" /translation="MKPAKVSLLRRLLHSLKHVDCNIAKRFPSTIKIVKLLMIFMVFT PISSIYAEDVYQNFEELKNNEDPSDYGVVTKETGSPVLVLAIHGGGIEGGTSEVAREL SKEYSMYLFEGLKSAGNSVLHITSTHFDEPRALKMTGNHEYVISLHGYAEEDQQIEVG GTDRVRAADLVEKLQHAGFPAVLLNMDHPHAGVSPNNIANKSKTGLSIQIEMSTGFRK SLFGIFSLKSRAVTQNERFYEFTEVMFRFLKNSY*" /label="pghL CDS" gene 1745826..1746584 /gene="pghL" /locus_tag="BSU_17820" /old_locus_tag="BSU17820" /label="pghL gene" upshifts 1745859 /Source="Nicolas_upshifts" /id="U1430" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.308691308691309" /psig="0.211788211788212" /xcortree=1323 /SigmaFactorBS="gttgatttggacttagaggcggagtagatgaaaccggccaaa gtatccctgctCcGccgtttgctccattccttgaagcatgttgattgtaacatagcca a" /listShort="yndL, S657, fosB, S658, S659" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1745875..1745894) /Source="Nicolas_upshift_promotors" /id="U1431" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=481 /SigmaFactorBS="caataattttacaattttaaTAGTTGATggaaaacgtttggc TATGTTACAATCAACATGCTtcaaggaatggagcaaacggcggagcagggatactttg g" /listShort="S655, S653, S652" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1745876) /Source="Nicolas_upshifts" /id="U1431" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=481 /SigmaFactorBS="caataattttacaattttaaTAGTTGATggaaaacgtttggc TATGTTACAATCAACATGCTtcaaggaatggagcaaacggcggagcagggatactttg g" /listShort="S655, S653, S652" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1745909..1745916) /Source="Nicolas_upshift_promotors" /id="U1431" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=481 /SigmaFactorBS="caataattttacaattttaaTAGTTGATggaaaacgtttggc TATGTTACAATCAACATGCTtcaaggaatggagcaaacggcggagcagggatactttg g" /listShort="S655, S653, S652" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(1746399..1746610) /Source="Nicolas_S_feature" /locus_tag="new_1915794_1916005_c" /HighExp="S8, S5, S7, S6, S4, ferm, nit, BT, Pyr, G/S" /AntisenseName="yndL" /AntisenseCor="0.82198535504067005" /AntisenseRegPval="-66.5" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.515" /TUlongSig="NA" /TUlongPSig="NA" /label="S656" downshifts 1746563 /Source="Nicolas_upshifts" /id="D972" /incds=0 /nref=3 /ntot=23 /MaxReadThrough="4.17889" /MaxDrop="5.0493" /score="15.340233" /energy="-10.4" /TU="U1428,U1430" /idTUdmin="U1428" /TUdmin="-1540" /isTUend="FALSE" /label="downshifts" S_feature 1746608..1747227 /Source="Nicolas_S_feature" /locus_tag="new_1916003_1916622" /HighExp="S8, S6, S7, S5, C30, BT, G135, LBGstat, GM 150, M/G" /AntisenseName="yndM" /AntisenseCor="0.75549671487088998" /AntisenseRegPval="-50.2" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigK" /TUshortPSig="0.212, 0.934" /TUlongSig="NA" /TUlongPSig="NA" /label="S657" CDS complement(1746611..1747150) /gene="yndM" /locus_tag="BSU_17830" /old_locus_tag="BSU17830" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_389666.1" /db_xref="EnsemblGenomes-Gn:BSU17830" /db_xref="EnsemblGenomes-Tr:CAB13667" /db_xref="GOA:O31816" /db_xref="InterPro:IPR019649" /db_xref="SubtiList:BG13449" /db_xref="UniProtKB/Swiss-Prot:O31816" /translation="MTIMNGFELHYLSFVYAQEFSSKNNNLGGQMKHIIALASKIAFT LALLYVILDRVYHASFLSVMFIALFLGFVSYLSGDMLVLPRTNNITASLADFGLSFVI LWVFVLTQTRNDFSPFGAALLSAACLTVFEYFFHRYLLKNVLDENFRNELSARDNTLQ YQTEAADELFPETKEKHKE*" /label="yndM CDS" gene complement(1746611..1747150) /gene="yndM" /locus_tag="BSU_17830" /old_locus_tag="BSU17830" /label="yndM gene" promotor_-10 complement(1747151..1747165) /Source="Nicolas_upshift_promotors" /id="U1432" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.515484515484515" /psig="0.515484515484515" /xcortree=865 /SigmaFactorBS="taagaaagtttcatacagctgaaaaaaataccAGTGTAAaca aaaacggactGTTTAAAATAGTAACatgaccattatgaatggttttgaattgcattat t" /listShort="yndM, S656" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1747157) /Source="Nicolas_upshifts" /id="U1432" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.515484515484515" /psig="0.515484515484515" /xcortree=865 /SigmaFactorBS="taagaaagtttcatacagctgaaaaaaataccAGTGTAAaca aaaacggactGTTTAAAATAGTAACatgaccattatgaatggttttgaattgcattat t" /listShort="yndM, S656" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1747179..1747185) /Source="Nicolas_upshift_promotors" /id="U1432" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.515484515484515" /psig="0.515484515484515" /xcortree=865 /SigmaFactorBS="taagaaagtttcatacagctgaaaaaaataccAGTGTAAaca aaaacggactGTTTAAAATAGTAACatgaccattatgaatggttttgaattgcattat t" /listShort="yndM, S656" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1747205..1747214 /Source="Nicolas_upshift_promotors" /id="U1433" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1668 /SigmaFactorBS="ccgtttttgtttacactggtatttttttcagctgtaTGAAAC TTTCttatgaaaaaagTCGTATATGTGGATGAtcagctttcaaggggggaatgatttg t" /listShort="fosB, S658, S659" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1747227..1747242 /Source="Nicolas_upshift_promotors" /id="U1433" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1668 /SigmaFactorBS="ccgtttttgtttacactggtatttttttcagctgtaTGAAAC TTTCttatgaaaaaagTCGTATATGTGGATGAtcagctttcaaggggggaatgatttg t" /listShort="fosB, S658, S659" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1747229 /Source="Nicolas_upshifts" /id="U1433" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1668 /SigmaFactorBS="ccgtttttgtttacactggtatttttttcagctgtaTGAAAC TTTCttatgaaaaaagTCGTATATGTGGATGAtcagctttcaaggggggaatgatttg t" /listShort="fosB, S658, S659" /GFF_Attribute="listLong" /label="upshifts" CDS 1747268..1747702 /gene="fosB" /locus_tag="BSU_17840" /old_locus_tag="BSU17840" /EC_number="2.5.1.-" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11244082, 16399398, 19763274, 23256780" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11244082, 16399398, 19763274, 23256780; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="magnesium-dependent bacillithiol-transferase" /protein_id="NP_389667.1" /db_xref="EnsemblGenomes-Gn:BSU17840" /db_xref="EnsemblGenomes-Tr:CAB13668" /db_xref="GOA:O31817" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR022858" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG13450" /db_xref="UniProtKB/Swiss-Prot:O31817" /translation="MEIKGINHLLFSVSHLDTSIDFYQKVFGAKLLVKGRTTAYFDMN GIWLALNEEPDIPRNDIKLSYTHIAFTIEDHEFEEMSAKLKRLHVNILPGRERDERDR KSIYFTDPDGHKFEFHTGTLQDRLRYYKQEKTHMHFYDETAF*" /label="fosB CDS" gene 1747268..1747702 /gene="fosB" /locus_tag="BSU_17840" /old_locus_tag="BSU17840" /label="fosB gene" CDS 1747560..1747907 /gene="yzzP" /locus_tag="BSU_17845" /old_locus_tag="BSU17845" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 27144405" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_009513960.1" /translation="MNAIENQFILPTLTATNLNFIPEPFKTGFDITNKKKRICTFMMK RPFDSTTIFHIRLNLKKGVGGDFMFGEGFYPTCSTMPYLLNCTSDWVKVKLKYTLHYI LYEESELFYQMLN*" /label="yzzP CDS" gene 1747560..1747907 /gene="yzzP" /locus_tag="BSU_17845" /old_locus_tag="BSU17845" /label="yzzP gene" S_feature 1747703..1748035 /Source="Nicolas_S_feature" /locus_tag="new_1917098_1917430" /HighExp="T0.30H, T1.0H, T1.30H, T2.0H, T-0.40H, T0.0H, T-1.10H, T2.30H, Salt, T-1.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.66836499999999999" /TUshortSig="SigWXY, Sig-, SigK" /TUshortPSig="1, 0.212, 0.934" /TUlongSig="NA" /TUlongPSig="NA" /label="S658" promotor_-35 1747994..1748003 /Source="Nicolas_upshift_promotors" /id="U1434" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=425 /SigmaFactorBS="ttccacgacctaaaaaaTGAAACGTTTttaagaagatgGCGT CTAATATTCTAAatgttcatattttgataaaagtttcctaaaggaaagaaaatttctt g" /listShort="S659" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1748015..1748030 /Source="Nicolas_upshift_promotors" /id="U1434" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=425 /SigmaFactorBS="ttccacgacctaaaaaaTGAAACGTTTttaagaagatgGCGT CTAATATTCTAAatgttcatattttgataaaagtttcctaaaggaaagaaaatttctt g" /listShort="S659" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1748037..1748215 /Source="Nicolas_S_feature" /locus_tag="new_1917432_1917610" /HighExp="T0.30H, T1.0H, T1.30H, T2.0H, T-0.40H, T-1.10H, T0.0H, T2.30H, T3.0H, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY, SigWXY, Sig-, SigK" /TUshortPSig="0.99, 1, 0.212, 0.934" /TUlongSig="NA" /TUlongPSig="NA" /label="S659" upshifts 1748037 /Source="Nicolas_upshifts" /id="U1434" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=425 /SigmaFactorBS="ttccacgacctaaaaaaTGAAACGTTTttaagaagatgGCGT CTAATATTCTAAatgttcatattttgataaaagtttcctaaaggaaagaaaatttctt g" /listShort="S659" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 1748106..1748185 /gene="ncrF" /locus_tag="BSU_misc_RNA_73" /product="putative conserved small untranslated RNA" /experiment="publication(s) with functional evidences, PMID:20525796" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20525796; Product type n: RNA" /label="ncrF RNA" gene 1748106..1748185 /gene="ncrF" /locus_tag="BSU_misc_RNA_73" /label="ncrF gene" downshifts 1748172 /Source="Nicolas_upshifts" /id="D973" /incds=0 /nref=16 /ntot=188 /MaxReadThrough="2.99425" /MaxDrop="4.30173" /score="-1.31226475" /energy="-14.3" /TU="U1433" /idTUdmin="U1434" /TUdmin=3 /isTUend="TRUE" /label="downshifts" CDS complement(1748244..1748861) /gene="lexA" /locus_tag="BSU_17850" /old_locus_tag="BSU17850" /function="16.8: Protect" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:14652736, 16267290, 16269821, 16855250, 17042786, 19684115, 24285298" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14652736, 16267290, 16269821, 16855250, 17042786, 19684115, 24285298; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of the SOS regulon" /protein_id="NP_389668.1" /db_xref="EnsemblGenomes-Gn:BSU17850" /db_xref="EnsemblGenomes-Tr:CAB13669" /db_xref="GOA:P31080" /db_xref="InterPro:IPR006197" /db_xref="InterPro:IPR006199" /db_xref="InterPro:IPR006200" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR015927" /db_xref="InterPro:IPR036286" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10678" /db_xref="UniProtKB/Swiss-Prot:P31080" /translation="MTKLSKRQLDILRFIKAEVKSKGYPPSVREIGEAVGLASSSTVH GHLARLETKGLIRRDPTKPRAIEILDEEVDIPQSQVVNVPVIGKVTAGSPITAVENIE EYFPLPDRMVPPDEHVFMLEIMGDSMIDAGILDKDYVIVKQQNTANNGEIVVAMTEDD EATVKRFYKEDTHIRLQPENPTMEPIILQNVSILGKVIGVFRTVH*" /label="lexA CDS" gene complement(1748244..1748861) /gene="lexA" /locus_tag="BSU_17850" /old_locus_tag="BSU17850" /label="lexA gene" downshifts complement(1748245) /Source="Nicolas_upshifts" /id="D974" /incds=0 /nref=186 /ntot=254 /MaxReadThrough="2.74616" /MaxDrop="7.90985" /score="8.16083322" /energy="-16.3" /TU="U1435" /idTUdmin="U1435" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1748885..1748904) /Source="Nicolas_upshift_promotors" /id="U1435" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.659340659340659" /psig=1 /xcortree=2083 /SigmaFactorBS="tatacgaacaaacgtttctgtcaattgttttttcgaacctaT GTTTGTActgtaaggaaaatCATGCTATAATCTTCTTAAAatcgacgttttgaggtgc g" /listShort="lexA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1748906) /Source="Nicolas_upshifts" /id="U1435" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.659340659340659" /psig=1 /xcortree=2083 /SigmaFactorBS="tatacgaacaaacgtttctgtcaattgttttttcgaacctaT GTTTGTActgtaaggaaaatCATGCTATAATCTTCTTAAAatcgacgttttgaggtgc g" /listShort="lexA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1748918..1748925) /Source="Nicolas_upshift_promotors" /id="U1435" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.659340659340659" /psig=1 /xcortree=2083 /SigmaFactorBS="tatacgaacaaacgtttctgtcaattgttttttcgaacctaT GTTTGTActgtaaggaaaatCATGCTATAATCTTCTTAAAatcgacgttttgaggtgc g" /listShort="lexA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1748941..1748948 /Source="Nicolas_upshift_promotors" /id="U1436" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=1508 /SigmaFactorBS="gcatgattttccttacagtacaaacataggttcgaaaaaacA ATTGACAgaaacgtttgttcGTATATACTGAAATTATAAAaatgcgaacaaacattcc t" /listShort="yneA, yneB, ynzC, S660, tkt" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1748960 /Source="Nicolas_upshifts" /id="U1436" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=1508 /SigmaFactorBS="gcatgattttccttacagtacaaacataggttcgaaaaaacA ATTGACAgaaacgtttgttcGTATATACTGAAATTATAAAaatgcgaacaaacattcc t" /listShort="yneA, yneB, ynzC, S660, tkt" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1748962..1748981 /Source="Nicolas_upshift_promotors" /id="U1436" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=1508 /SigmaFactorBS="gcatgattttccttacagtacaaacataggttcgaaaaaacA ATTGACAgaaacgtttgttcGTATATACTGAAATTATAAAaatgcgaacaaacattcc t" /listShort="yneA, yneB, ynzC, S660, tkt" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1749011..1749328 /gene="dinK" /locus_tag="BSU_17860" /old_locus_tag="BSU17860" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12581363, 16267290, 16549676, 20400548, 20807205, 23728628" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12581363, 16267290, 16549676, 20400548, 20807205, 23728628; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="cell division inhibitor" /protein_id="NP_389669.1" /db_xref="EnsemblGenomes-Gn:BSU17860" /db_xref="EnsemblGenomes-Tr:CAB13670" /db_xref="GOA:Q45056" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR022887" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG11820" /db_xref="UniProtKB/Swiss-Prot:Q45056" /translation="MIMSKESIIFVGLFTVILSAVILMLSYTSSGQELNQYVKIEVQQ GDTLWSIADQVADTKKINKNDFIEWVADKNQLQTSDIQPGDELVIPLKKKHQDAYELA TVR*" /label="dinK CDS" gene 1749011..1749328 /gene="dinK" /locus_tag="BSU_17860" /old_locus_tag="BSU17860" /label="dinK gene" promotor_-10 complement(1749028..1749046) /Source="Nicolas_upshift_promotors" /id="U1437" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2844 /SigmaFactorBS="atatgacagcataaggataaccgcGCTCAAAAtcactgtaaa cagACCGACAAAAATAATAGATtctttactcatgatcataacctccaacaggaatgtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1749031) /Source="Nicolas_upshifts" /id="U1437" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2844 /SigmaFactorBS="atatgacagcataaggataaccgcGCTCAAAAtcactgtaaa cagACCGACAAAAATAATAGATtctttactcatgatcataacctccaacaggaatgtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1749060..1749067) /Source="Nicolas_upshift_promotors" /id="U1437" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2844 /SigmaFactorBS="atatgacagcataaggataaccgcGCTCAAAAtcactgtaaa cagACCGACAAAAATAATAGATtctttactcatgatcataacctccaacaggaatgtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1749347..1750000 /gene="dinL" /locus_tag="BSU_17870" /old_locus_tag="BSU17870" /function="16.9: Replicate" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12581363, 16267290, 17020588, 19060143, 22933559; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative site-specific recombinase, resolvase" /protein_id="NP_389670.1" /db_xref="EnsemblGenomes-Gn:BSU17870" /db_xref="EnsemblGenomes-Tr:CAB13671" /db_xref="GOA:Q45057" /db_xref="InterPro:IPR006119" /db_xref="InterPro:IPR036162" /db_xref="SubtiList:BG11821" /db_xref="UniProtKB/Swiss-Prot:Q45057" /translation="MKALIYARVSTNKEQQETSLKRQEEELTAIAAENGMEVVKVISE KASGYEMDRDGVFELLDEIKNADIDVILVQDETRLGRGNAKIALLHCIYREGVKVYTT AHRGELELSEADSMVLEIVSIVEEYQRKIHNMKIRRGMKRAVKNGFKPQKNLKNQHGN SGKEKIEVPISEIVRLRANKLTFAEIAATLRGFGYDVSKATVHRRFQEYIENEETAE* " /label="dinL CDS" gene 1749347..1750000 /gene="dinL" /locus_tag="BSU_17870" /old_locus_tag="BSU17870" /label="dinL gene" promotor_-35 1750003..1750010 /Source="Nicolas_upshift_promotors" /id="U1438" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.965034965034965" /psig=1 /xcortree=2084 /SigmaFactorBS="gagaatgaagagactgcagagtgaatCAGTTGTAaaactttt tttgaTCTAGTACTATATAGACAAAatgcaataaaggagtttaacatgatttcaaacg c" /listShort="ynzC, S660, tkt" /listLong="yneE, yneF" /label="promotor_-35" promotor_-10 1750024..1750043 /Source="Nicolas_upshift_promotors" /id="U1438" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.965034965034965" /psig=1 /xcortree=2084 /SigmaFactorBS="gagaatgaagagactgcagagtgaatCAGTTGTAaaactttt tttgaTCTAGTACTATATAGACAAAatgcaataaaggagtttaacatgatttcaaacg c" /listShort="ynzC, S660, tkt" /listLong="yneE, yneF" /label="promotor_-10" upshifts 1750037 /Source="Nicolas_upshifts" /id="U1438" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.965034965034965" /psig=1 /xcortree=2084 /SigmaFactorBS="gagaatgaagagactgcagagtgaatCAGTTGTAaaactttt tttgaTCTAGTACTATATAGACAAAatgcaataaaggagtttaacatgatttcaaacg c" /listShort="ynzC, S660, tkt" /listLong="yneE, yneF" /label="upshifts" CDS 1750064..1750297 /gene="ynzC" /locus_tag="BSU_17880" /old_locus_tag="BSU17880" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12581363, 16267290, 18431750,19306341, 22333191, 22933559, 23099262" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389671.1" /db_xref="EnsemblGenomes-Gn:BSU17880" /db_xref="EnsemblGenomes-Tr:CAB13672" /db_xref="GOA:O31818" /db_xref="InterPro:IPR009242" /db_xref="PDB:2HEP" /db_xref="PDB:2JVD" /db_xref="PDB:3BHP" /db_xref="SubtiList:BG13466" /db_xref="UniProtKB/Swiss-Prot:O31818" /translation="MISNAKIARINELAAKAKAGVITEEEKAEQQKLRQEYLKGFRSS MKNTLKSVKIIDPEGNDVTPEKLKREQRNNKLH*" /label="ynzC CDS" gene 1750064..1750297 /gene="ynzC" /locus_tag="BSU_17880" /old_locus_tag="BSU17880" /label="ynzC gene" S_feature 1750298..1750433 /Source="Nicolas_S_feature" /locus_tag="new_1919693_1919828" /HighExp="M40t90, M40t45, dia15, C90, Etha, H2O2, T5.0H, Salt, dia5, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S660" promotor_-35 1750401..1750408 /Source="Nicolas_upshift_promotors" /id="U1439" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.976023976023976" /psig="0.999000999001" /xcortree=2357 /SigmaFactorBS="aagtttctctcaaatttaagctgaaaCAGTTGAGaaaaagtc gtcagACATTTATGATGTAAGGGTAcaacacataaggaaggggatttttatggataca a" /listShort="tkt, yneE" /listLong="yneF" /label="promotor_-35" promotor_-10 1750422..1750441 /Source="Nicolas_upshift_promotors" /id="U1439" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.976023976023976" /psig="0.999000999001" /xcortree=2357 /SigmaFactorBS="aagtttctctcaaatttaagctgaaaCAGTTGAGaaaaagtc gtcagACATTTATGATGTAAGGGTAcaacacataaggaaggggatttttatggataca a" /listShort="tkt, yneE" /listLong="yneF" /label="promotor_-10" upshifts 1750435 /Source="Nicolas_upshifts" /id="U1439" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.976023976023976" /psig="0.999000999001" /xcortree=2357 /SigmaFactorBS="aagtttctctcaaatttaagctgaaaCAGTTGAGaaaaagtc gtcagACATTTATGATGTAAGGGTAcaacacataaggaaggggatttttatggataca a" /listShort="tkt, yneE" /listLong="yneF" /label="upshifts" CDS 1750466..1752469 /gene="tktA" /locus_tag="BSU_17890" /old_locus_tag="BSU17890" /EC_number="2.2.1.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9696621, 12682299, 12882400, 27739585" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9696621, 12682299, 12882400, 27739585; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="transketolase" /protein_id="NP_389672.1" /db_xref="EnsemblGenomes-Gn:BSU17890" /db_xref="EnsemblGenomes-Tr:CAB13673" /db_xref="GOA:P45694" /db_xref="InterPro:IPR005474" /db_xref="InterPro:IPR005475" /db_xref="InterPro:IPR005478" /db_xref="InterPro:IPR009014" /db_xref="InterPro:IPR020826" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR033247" /db_xref="InterPro:IPR033248" /db_xref="SubtiList:BG11247" /db_xref="UniProtKB/Swiss-Prot:P45694" /translation="MDTIEKKSVATIRTLSIDAIEKANSGHPGMPMGAAPMAYTLWTK FMNVSPANPGWFNRDRFVLSAGHGSALLYSMLHLSGFDLSIEDLKGFRQWGSKTPGHP EFGHTAGVDATTGPLGQGIAMAVGMAIAERHLAETYNRDSFNVVDHYTYSICGDGDLM EGISSEAASLAGHLQLGRLIVLYDSNDISLDGDLDRSFSENVKQRFEAMNWEVLYVED GNNIEELTAAIEKARQNEKKPTLIEVKTTIGFGSPNRAGTSGVHGAPLGKEESKLTKE AYAWTYEEDFYVPSEVYEHFAVAVKESGEKKEQEWNAQFAKYKEVYPELAEQLELAIK GELPKDWDQEVPVYEKGSSLASRASSGEVLNGLAKKIPFFVGGSADLAGSNKTTIKNA GDFTAVDYSGKNFWFGVREFAMGAALNGMALHGGLRVFGGTFFVFSDYLRPAIRLAAL MGLPVTYVFTHDSIAVGEDGPTHEPVEQLASLRAMPNLSLIRPADGNETAAAWKLAVQ STDHPTALVLTRQNLPTIDQTSEEALAGVEKGAYVVSKSKNETPDALLIASGSEVGLA IEAQAELAKENIDVSVVSMPSMDRFEKQSDEYKNEVLPADVKKRLAIEMGSSFGWGKY TGLEGDVLGIDRFGASAPGETIINEYGFSVPNVVNRVKALINK*" /label="tktA CDS" gene 1750466..1752469 /gene="tktA" /locus_tag="BSU_17890" /old_locus_tag="BSU17890" /label="tktA gene" misc_feature complement(1750670..1750689) /Source="Nicolas_upshift_promotors" /id="U1440" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.713286713286713" /psig="0.78921078921079" /xcortree=31 /SigmaFactorBS="ccactggcggaatcccttaagatcttcaatactaagatcaaa cccgcttaaatgaagcATGCTGTATAATAGTGCTGAcccgtgtccagcagataaaaca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1750687) /Source="Nicolas_upshifts" /id="U1440" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.713286713286713" /psig="0.78921078921079" /xcortree=31 /SigmaFactorBS="ccactggcggaatcccttaagatcttcaatactaagatcaaa cccgcttaaatgaagcATGCTGTATAATAGTGCTGAcccgtgtccagcagataaaaca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1752459 /Source="Nicolas_upshifts" /id="D975" /incds=0 /nref=230 /ntot=257 /MaxReadThrough="4.5478" /MaxDrop="6.66676" /score="16.4587041" /energy="-10.6" /TU="U1439" /idTUdmin="U1436" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1752471..1753129) /Source="Nicolas_S_feature" /locus_tag="new_1921866_1922524_c" /HighExp="Lbstat, C30, Salt, BC, S7, LPhT, S8, M0t90, T-0.40H, Glucon" /AntisenseName="yneE" /AntisenseCor="4.3891878649396997E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.604, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S661" upshifts 1752569 /Source="Nicolas_upshifts" /id="U1441" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.783216783216783" /psig="0.996003996003996" /xcortree=441 /SigmaFactorBS="tgtttatccgacaaaaatagtattggctgtttaacagtaata gacaattctttcttttcttCTTTTGTATAATAGAGAGCAaatgaaatgctgctggaaa a" /listShort="yneE, yneF, S662, S663, ccdA, yneI" /listLong="yneJ" /label="upshifts" misc_feature 1752570..1752589 /Source="Nicolas_upshift_promotors" /id="U1441" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.783216783216783" /psig="0.996003996003996" /xcortree=441 /SigmaFactorBS="tgtttatccgacaaaaatagtattggctgtttaacagtaata gacaattctttcttttcttCTTTTGTATAATAGAGAGCAaatgaaatgctgctggaaa a" /listShort="yneE, yneF, S662, S663, ccdA, yneI" /listLong="yneJ" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 1752622..1753068 /gene="pcfA" /locus_tag="BSU_17900" /old_locus_tag="BSU17900" /experiment="publication(s) with functional evidences, PMID:19682252, 25041308, 22720735, 27489185" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19682252, 25041308, 22720735, 27489185; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor controlling DNA replication" /protein_id="NP_389673.1" /db_xref="EnsemblGenomes-Gn:BSU17900" /db_xref="EnsemblGenomes-Tr:CAB13674" /db_xref="GOA:P45707" /db_xref="InterPro:IPR019683" /db_xref="PDB:4TPS" /db_xref="SubtiList:BG11248" /db_xref="UniProtKB/Swiss-Prot:P45707" /translation="MERHYYTYLIKEEFANHYFGRESVMFELFQDYHWTSLEKQQYEM TEKQIQYITQPIPILHMHQRLKMNLNKTDYRQLDYIYRIALPKAKGHATFMMKEHMIE IVASGDYEAETIFFEVLRKVSPCFLAMDFNSKRYGWLNPVKERNFV*" /label="pcfA CDS" gene 1752622..1753068 /gene="pcfA" /locus_tag="BSU_17900" /old_locus_tag="BSU17900" /label="pcfA gene" misc_feature 1753092..1753111 /Source="Nicolas_upshift_promotors" /id="U1442" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.973026973026973" /psig=1 /xcortree=2574 /SigmaFactorBS="atccggtgaaagaaagaaattttgtctaaaaccgaagaaaaa gagatgtaaaTGTTGTATAATAGCTTTTGGtttagtacactttaaactagacaacatg a" /listShort="yneF, S662, S663, ccdA, yneI, yneJ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1753100 /Source="Nicolas_upshifts" /id="U1442" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.973026973026973" /psig=1 /xcortree=2574 /SigmaFactorBS="atccggtgaaagaaagaaattttgtctaaaaccgaagaaaaa gagatgtaaaTGTTGTATAATAGCTTTTGGtttagtacactttaaactagacaacatg a" /listShort="yneF, S662, S663, ccdA, yneI, yneJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1753111..1753128) /Source="Nicolas_upshift_promotors" /id="U1443" /multdbtbs="-" /comp="M15" /sig="SigA" /pcomp="0.394605394605395" /psig="0.604395604395604" /xcortree=3127 /SigmaFactorBS="aacaacgcccactaggatgccaacccataaagtcatttTATT TcctccttcatgttgtctaGTTTAAAGTGTACTAAACcaaaagctattatacaacatt t" /listShort="S661" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1753129) /Source="Nicolas_upshifts" /id="U1443" /multdbtbs="-" /comp="M15" /sig="SigA" /pcomp="0.394605394605395" /psig="0.604395604395604" /xcortree=3127 /SigmaFactorBS="aacaacgcccactaggatgccaacccataaagtcatttTATT TcctccttcatgttgtctaGTTTAAAGTGTACTAAACcaaaagctattatacaacatt t" /listShort="S661" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1753147..1753151) /Source="Nicolas_upshift_promotors" /id="U1443" /multdbtbs="-" /comp="M15" /sig="SigA" /pcomp="0.394605394605395" /psig="0.604395604395604" /xcortree=3127 /SigmaFactorBS="aacaacgcccactaggatgccaacccataaagtcatttTATT TcctccttcatgttgtctaGTTTAAAGTGTACTAAACcaaaagctattatacaacatt t" /listShort="S661" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1753154..1753372 /gene="yneF" /locus_tag="BSU_17910" /old_locus_tag="BSU17910" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyltransferase" /protein_id="NP_389674.1" /db_xref="EnsemblGenomes-Gn:BSU17910" /db_xref="EnsemblGenomes-Tr:CAB13675" /db_xref="GOA:P45708" /db_xref="InterPro:IPR005359" /db_xref="SubtiList:BG11249" /db_xref="UniProtKB/Swiss-Prot:P45708" /translation="MTLWVGILVGVVALLIGVALGFFIARKYMMSYLKKNPPINEQML RMMMMQMGMKPSQKKINQMMKAMNNQTK*" /label="yneF CDS" gene 1753154..1753372 /gene="yneF" /locus_tag="BSU_17910" /old_locus_tag="BSU17910" /label="yneF gene" downshifts 1753384 /Source="Nicolas_upshifts" /id="D976" /incds=0 /nref=243 /ntot=260 /MaxReadThrough="3.51446" /MaxDrop="7.54782" /score="0.133420982" /energy="-4.3" /TU="U1441,U1442" /idTUdmin="U1439" /TUdmin=287 /isTUend="FALSE" /label="downshifts" S_feature 1753429..1753728 /Source="Nicolas_S_feature" /locus_tag="new_1922824_1923123" /HighExp="S4, S3, S5, G180, S8, T5.0H, LoTm, G135, S6, S7" /AntisenseName="ynzD" /AntisenseCor="-0.33023056016157298" /AntisenseRegPval="-7.5" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S662" CDS complement(1753446..1753619) /gene="spo0D" /locus_tag="BSU_17920" /old_locus_tag="BSU17920" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11679073, 15187183, 17350627, 22303282, 23378509, 27965289" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11679073, 15187183, 17350627, 22303282, 23378509, 27965289; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="Spo0A-P phosphatase" /protein_id="NP_389675.1" /db_xref="EnsemblGenomes-Gn:BSU17920" /db_xref="EnsemblGenomes-Tr:CAB13676" /db_xref="GOA:O31819" /db_xref="InterPro:IPR018540" /db_xref="InterPro:IPR037208" /db_xref="SubtiList:BG13467" /db_xref="UniProtKB/Swiss-Prot:O31819" /translation="MIREHLLKEIEKKRAELLQIVMANGMTSHITIELSQELDHLLIQ YQKQRLRAVAGDE*" /label="spo0D CDS" gene complement(1753446..1753619) /gene="spo0D" /locus_tag="BSU_17920" /old_locus_tag="BSU17920" /label="spo0D gene" downshifts complement(1753459) /Source="Nicolas_upshifts" /id="D977" /incds=0 /nref=109 /ntot=219 /MaxReadThrough="4.0851" /MaxDrop="5.22565" /score="1.92055758" /energy="-4.3" /TU="U1444,U1446" /idTUdmin="U1444" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1753657..1753676) /Source="Nicolas_upshift_promotors" /id="U1444" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.784215784215784" /psig="0.998001998001998" /xcortree=568 /SigmaFactorBS="ttgacattgagacattatactccttctCATTTGAAaattagt ataaatATGGATATAATATAAACATTcactttgaagatctaatgtatgaaaggataca t" /listShort="ynzD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1753664) /Source="Nicolas_upshifts" /id="U1444" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.784215784215784" /psig="0.998001998001998" /xcortree=568 /SigmaFactorBS="ttgacattgagacattatactccttctCATTTGAAaattagt ataaatATGGATATAATATAAACATTcactttgaagatctaatgtatgaaaggataca t" /listShort="ynzD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1753690..1753697) /Source="Nicolas_upshift_promotors" /id="U1444" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.784215784215784" /psig="0.998001998001998" /xcortree=568 /SigmaFactorBS="ttgacattgagacattatactccttctCATTTGAAaattagt ataaatATGGATATAATATAAACATTcactttgaagatctaatgtatgaaaggataca t" /listShort="ynzD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1753699..1753707 /Source="Nicolas_upshift_promotors" /id="U1445" /multdbtbs="SigA" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=535 /SigmaFactorBS="tatccatatttatactaattttcaaatgaGAAGGAGTAtaat gtctcaaTGTCAAATTAAATTATATAagttttttctgaaaatagaaatccttcaagtg a" /listShort="S663, ccdA, yneI, yneJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1753719..1753738) /Source="Nicolas_upshift_promotors" /id="U1446" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.492507492507492" /psig="0.999000999001" /xcortree=3128 /SigmaFactorBS="catttcatttttttaacactttcacttgaagGATTTCTAttt tcagaaaaaacTTATATAATTTAATTTGACAttgagacattatactccttctcatttg a" /listShort="ynzD, S661" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 1753719..1753737 /Source="Nicolas_upshift_promotors" /id="U1445" /multdbtbs="SigA" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=535 /SigmaFactorBS="tatccatatttatactaattttcaaatgaGAAGGAGTAtaat gtctcaaTGTCAAATTAAATTATATAagttttttctgaaaatagaaatccttcaagtg a" /listShort="S663, ccdA, yneI, yneJ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1753730..1753838 /Source="Nicolas_S_feature" /locus_tag="new_1923125_1923233" /HighExp="T4.0H, T3.30H, T3.0H, S2, Lbstat, T5.0H, T2.30H, S4, T-1.40H, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH, SigA, SigA" /TUshortPSig="0.999, 1, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S663" upshifts 1753730 /Source="Nicolas_upshifts" /id="U1445" /multdbtbs="SigA" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=535 /SigmaFactorBS="tatccatatttatactaattttcaaatgaGAAGGAGTAtaat gtctcaaTGTCAAATTAAATTATATAagttttttctgaaaatagaaatccttcaagtg a" /listShort="S663, ccdA, yneI, yneJ" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1753731) /Source="Nicolas_upshifts" /id="U1446" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.492507492507492" /psig="0.999000999001" /xcortree=3128 /SigmaFactorBS="catttcatttttttaacactttcacttgaagGATTTCTAttt tcagaaaaaacTTATATAATTTAATTTGACAttgagacattatactccttctcatttg a" /listShort="ynzD, S661" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1753753..1753760) /Source="Nicolas_upshift_promotors" /id="U1446" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.492507492507492" /psig="0.999000999001" /xcortree=3128 /SigmaFactorBS="catttcatttttttaacactttcacttgaagGATTTCTAttt tcagaaaaaacTTATATAATTTAATTTGACAttgagacattatactccttctcatttg a" /listShort="ynzD, S661" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1753839..1754546 /gene="ccdA" /locus_tag="BSU_17930" /old_locus_tag="BSU17930" /function="16.10: Respire" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15849754, 16771673, 16850406, 19682263" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16771673, 16850406, 19682263; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome c-type biogenesis protein CcdA; thiol-disulfide oxido-reductase" /protein_id="NP_389676.1" /db_xref="EnsemblGenomes-Gn:BSU17930" /db_xref="EnsemblGenomes-Tr:CAB13677" /db_xref="GOA:P45706" /db_xref="InterPro:IPR003834" /db_xref="SubtiList:BG11240" /db_xref="UniProtKB/Swiss-Prot:P45706" /translation="MGDVNYFLTFGAGFLSFISPCCLPLYPAFLSYITGVSMDDVKTE KLLLQKRSLFHTLCFLLGFSVIFIALGYGTSFIGSLFRDYHDAIRQIGALLIILFGFI TLGVFRPEAMMKERRIHFKHKPSGFLGSVLIGMAFAAGWTPCTGPILAAVITLAGTNP GSAVPYMMLYVLGFAVPFLLLSFFITKLKWIRKNQLFIMKAGGVLMIVIGVLLFFNWM SLIIILLSDLFGGFTGF*" /label="ccdA CDS" gene 1753839..1754546 /gene="ccdA" /locus_tag="BSU_17930" /old_locus_tag="BSU17930" /label="ccdA gene" promotor_-35 1754566..1754573 /Source="Nicolas_upshift_promotors" /id="U1447" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=2256 /SigmaFactorBS="ttactggtttttgacggtaaattactttcgtacTACTACTAa tccttttgttTTTGGTACAATAAGACTATTatctgtggaaatcgattgttggagggga a" /listShort="yneI, yneJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1754585..1754604 /Source="Nicolas_upshift_promotors" /id="U1447" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=2256 /SigmaFactorBS="ttactggtttttgacggtaaattactttcgtacTACTACTAa tccttttgttTTTGGTACAATAAGACTATTatctgtggaaatcgattgttggagggga a" /listShort="yneI, yneJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1754593 /Source="Nicolas_upshifts" /id="U1447" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.891108891108891" /psig="0.999000999001" /xcortree=2256 /SigmaFactorBS="ttactggtttttgacggtaaattactttcgtacTACTACTAa tccttttgttTTTGGTACAATAAGACTATTatctgtggaaatcgattgttggagggga a" /listShort="yneI, yneJ" /GFF_Attribute="listLong" /label="upshifts" CDS 1754635..1754997 /gene="yneI" /locus_tag="BSU_17940" /old_locus_tag="BSU17940" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10781554; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative response regulator (CheY homolog)" /protein_id="NP_389677.1" /db_xref="EnsemblGenomes-Gn:BSU17940" /db_xref="EnsemblGenomes-Tr:CAB13678" /db_xref="GOA:P45709" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="SubtiList:BG11250" /db_xref="UniProtKB/Swiss-Prot:P45709" /translation="MTRVLVVDDAKFMRVKIREILEEANYIIAGEAADGEQAADLYKK LRPDLVTMDITMPVKNGIKALRDILTFDPKAKVIMCTAMRQQRIVTEAIELGAKDFIV KPFEETKVLEAVSRVMGH*" /label="yneI CDS" gene 1754635..1754997 /gene="yneI" /locus_tag="BSU_17940" /old_locus_tag="BSU17940" /label="yneI gene" promotor_-35 1755015..1755018 /Source="Nicolas_upshift_promotors" /id="U1448" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.637362637362637" /psig="0.993006993006993" /xcortree=3154 /SigmaFactorBS="ttatgggacattaaagtcatttcttttcaaaATGGttttttt tattgttTTGGAGTATAGTATATAGTAtcaacactccgagaaacaaaggaatgataag t" /listShort="yneJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1755033..1755052 /Source="Nicolas_upshift_promotors" /id="U1448" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.637362637362637" /psig="0.993006993006993" /xcortree=3154 /SigmaFactorBS="ttatgggacattaaagtcatttcttttcaaaATGGttttttt tattgttTTGGAGTATAGTATATAGTAtcaacactccgagaaacaaaggaatgataag t" /listShort="yneJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1755044 /Source="Nicolas_upshifts" /id="U1448" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.637362637362637" /psig="0.993006993006993" /xcortree=3154 /SigmaFactorBS="ttatgggacattaaagtcatttcttttcaaaATGGttttttt tattgttTTGGAGTATAGTATATAGTAtcaacactccgagaaacaaaggaatgataag t" /listShort="yneJ" /GFF_Attribute="listLong" /label="upshifts" CDS 1755076..1755567 /gene="yneJ" /locus_tag="BSU_17950" /old_locus_tag="BSU17950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10781554, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_389678.1" /db_xref="EnsemblGenomes-Gn:BSU17950" /db_xref="EnsemblGenomes-Tr:CAB13679" /db_xref="GOA:P45710" /db_xref="InterPro:IPR009916" /db_xref="InterPro:IPR031306" /db_xref="SubtiList:BG11251" /db_xref="UniProtKB/Swiss-Prot:P45710" /translation="MISMMIIVSSIIAVLMAVAVMVVRIKSSDKPVSPKKIILPPIFM STGALMFLFPVFWVTGAEFLEAFTLGVIFSIFLIKTSKFEIKNNEIYMKRSKAFVFIL VGLLVIRIVMKSILSTSIDYGALSGMFWILAFGMIVPWRIAMYLSYRKLHNELQSSNI QMN*" /label="yneJ CDS" gene 1755076..1755567 /gene="yneJ" /locus_tag="BSU_17950" /old_locus_tag="BSU17950" /label="yneJ gene" downshifts 1755563 /Source="Nicolas_upshifts" /id="D978" /incds=0 /nref=110 /ntot=273 /MaxReadThrough="1.09905" /MaxDrop="5.9692" /score="16.4219082" /energy="-9.7" /TU="NA" /idTUdmin="U1445" /TUdmin=2 /isTUend="TRUE" /label="downshifts" CDS complement(1755598..1756026) /gene="yneK" /locus_tag="BSU_17960" /old_locus_tag="BSU17960" /experiment="publication(s) with functional evidences, PMID:23060960" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23060960; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor interacting with DynA" /protein_id="NP_389679.1" /db_xref="EnsemblGenomes-Gn:BSU17960" /db_xref="EnsemblGenomes-Tr:CAB13680" /db_xref="InterPro:IPR020203" /db_xref="SubtiList:BG11252" /db_xref="UniProtKB/Swiss-Prot:P45711" /translation="MLEGWFLWFILFWVIMMVVLLSIGGFFMFRKFLKRLPKEDGRSE LDWQDYYIENSRHLWNDENKQFLDELTAPVPELFRDAAKAKIAGKIGELALKEKVAKI DQQLMIKGYILATPKRDHTFLKRHLRDKKIDLEPYQTLLK*" /label="yneK CDS" gene complement(1755598..1756026) /gene="yneK" /locus_tag="BSU_17960" /old_locus_tag="BSU17960" /label="yneK gene" downshifts complement(1755615) /Source="Nicolas_upshifts" /id="D979" /incds=0 /nref=188 /ntot=245 /MaxReadThrough="1.60911" /MaxDrop="5.09033" /score="10.710816" /energy="-9.7" /TU="NA" /idTUdmin="U1449" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1756044..1756063) /Source="Nicolas_upshift_promotors" /id="U1449" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.796203796203796" /psig="0.999000999001" /xcortree=3159 /SigmaFactorBS="gacgtctatcacttttttctattctttttttaCTGTGTTCtt ctaatctctctTCGTATACAATATGGTTAGAataagggggaatgattgatgctggaag g" /listShort="yneK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1756056) /Source="Nicolas_upshifts" /id="U1449" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.796203796203796" /psig="0.999000999001" /xcortree=3159 /SigmaFactorBS="gacgtctatcacttttttctattctttttttaCTGTGTTCtt ctaatctctctTCGTATACAATATGGTTAGAataagggggaatgattgatgctggaag g" /listShort="yneK" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1756058..1756143) /Source="Nicolas_S_feature" /locus_tag="new_1925453_1925538_c" /HighExp="S8, S6, S7, LBGstat, C30, dia15, S0, Cold, T1.0H, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.958, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S664" promotor_-35 complement(1756077..1756084) /Source="Nicolas_upshift_promotors" /id="U1449" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.796203796203796" /psig="0.999000999001" /xcortree=3159 /SigmaFactorBS="gacgtctatcacttttttctattctttttttaCTGTGTTCtt ctaatctctctTCGTATACAATATGGTTAGAataagggggaatgattgatgctggaag g" /listShort="yneK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1756114..1756123 /Source="Nicolas_upshift_promotors" /id="U1450" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1415 /SigmaFactorBS="agaagaacacagtaaaaaaagaatagaaaaaagtgatagacG TCTAGTCAAaagagatagtagATCATATTCTATTGTATAGTgaatctgctatttggcc a" /listShort="S665" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1756133..1756242 /Source="Nicolas_S_feature" /locus_tag="new_1925528_1925637" /HighExp="S8, BT, B36, S7, G/S, Pyr, B60, S6, Glucon, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S665" upshifts 1756133 /Source="Nicolas_upshifts" /id="U1450" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1415 /SigmaFactorBS="agaagaacacagtaaaaaaagaatagaaaaaagtgatagacG TCTAGTCAAaagagatagtagATCATATTCTATTGTATAGTgaatctgctatttggcc a" /listShort="S665" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1756136..1756155 /Source="Nicolas_upshift_promotors" /id="U1450" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1415 /SigmaFactorBS="agaagaacacagtaaaaaaagaatagaaaaaagtgatagacG TCTAGTCAAaagagatagtagATCATATTCTATTGTATAGTgaatctgctatttggcc a" /listShort="S665" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1756138..1756157) /Source="Nicolas_upshift_promotors" /id="U1451" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.53946053946054" /psig="0.958041958041958" /xcortree=1633 /SigmaFactorBS="atcgtcaaataccctctagtgactctccCATGgccaaatagc agatTCACTATACAATAGAATATGatctactatctcttttgactagacgtctatcact t" /listShort="S664, yneK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1756143) /Source="Nicolas_upshifts" /id="U1451" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.53946053946054" /psig="0.958041958041958" /xcortree=1633 /SigmaFactorBS="atcgtcaaataccctctagtgactctccCATGgccaaatagc agatTCACTATACAATAGAATATGatctactatctcttttgactagacgtctatcact t" /listShort="S664, yneK" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1756145..1756228) /Source="Nicolas_S_feature" /locus_tag="new_1925540_1925623_c" /HighExp="S8, S6, S7, C30, BT, S5, Pyr, Glucon, BC, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S666" promotor_-35 complement(1756172..1756175) /Source="Nicolas_upshift_promotors" /id="U1451" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.53946053946054" /psig="0.958041958041958" /xcortree=1633 /SigmaFactorBS="atcgtcaaataccctctagtgactctccCATGgccaaatagc agatTCACTATACAATAGAATATGatctactatctcttttgactagacgtctatcact t" /listShort="S664, yneK" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1756199 /Source="Nicolas_upshifts" /id="D980" /incds=0 /nref=9 /ntot=30 /MaxReadThrough="3.76639" /MaxDrop="5.34013" /score="5.70696998" /energy="-12.7" /TU="U1450" /idTUdmin="U1450" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" CDS complement(1756260..1756652) /gene="cotM" /locus_tag="BSU_17970" /old_locus_tag="BSU17970" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9068633, 11150673" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9068633, 11150673; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="spore coat protein (outer)" /protein_id="NP_389680.1" /db_xref="EnsemblGenomes-Gn:BSU17970" /db_xref="EnsemblGenomes-Tr:CAB13681" /db_xref="GOA:Q45058" /db_xref="InterPro:IPR008978" /db_xref="SubtiList:BG11822" /db_xref="UniProtKB/Swiss-Prot:Q45058" /translation="MWRNASMNHSKRNDANDFDSMDEWLRQFFEDPFAWYDETLPIDL YETSQQYIIEADLTFLQPTQVTVTLSGCEFILTVKSSGQTFEKQMMLPFYFNDKNIQV ECENQILTVAVNKETEDGSSFSLQFPLS*" /label="cotM CDS" gene complement(1756260..1756652) /gene="cotM" /locus_tag="BSU_17970" /old_locus_tag="BSU17970" /label="cotM gene" downshifts complement(1756273) /Source="Nicolas_upshifts" /id="D981" /incds=0 /nref=20 /ntot=92 /MaxReadThrough="4.44864" /MaxDrop="4.9615" /score="11.5991121" /energy="-12.7" /TU="U1454" /idTUdmin="U1456" /TUdmin=486 /isTUend="FALSE" /label="downshifts" promotor_-35 1756495..1756500 /Source="Nicolas_upshift_promotors" /id="U1452" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=439 /SigmaFactorBS="cttgtgtaggctgtaaaaaagtcagatccgcttctATAATAt actgctgacttgttTCATATAAATCAATAGGCAatgtttcgtcgtaccaggcgaaggg g" /listShort="S667" /listLong="S668, citB, S669, yneN" /label="promotor_-35" promotor_-10 1756516..1756534 /Source="Nicolas_upshift_promotors" /id="U1452" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=439 /SigmaFactorBS="cttgtgtaggctgtaaaaaagtcagatccgcttctATAATAt actgctgacttgttTCATATAAATCAATAGGCAatgtttcgtcgtaccaggcgaaggg g" /listShort="S667" /listLong="S668, citB, S669, yneN" /label="promotor_-10" upshifts 1756520 /Source="Nicolas_upshifts" /id="U1452" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=439 /SigmaFactorBS="cttgtgtaggctgtaaaaaagtcagatccgcttctATAATAt actgctgacttgttTCATATAAATCAATAGGCAatgtttcgtcgtaccaggcgaaggg g" /listShort="S667" /listLong="S668, citB, S669, yneN" /label="upshifts" promotor_-35 1756630..1756634 /Source="Nicolas_upshift_promotors" /id="U1453" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=1243 /SigmaFactorBS="aatcattcgcatcgttgcgttttgaatggTTCATggaagcat tCCTCCACATATCAACcttgctttacatcatatgcggtggattataaatgggtgaacg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1756644..1756658 /Source="Nicolas_upshift_promotors" /id="U1453" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=1243 /SigmaFactorBS="aatcattcgcatcgttgcgttttgaatggTTCATggaagcat tCCTCCACATATCAACcttgctttacatcatatgcggtggattataaatgggtgaacg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1756659..1756678) /Source="Nicolas_upshift_promotors" /id="U1454" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1290 /SigmaFactorBS="aagaaaagcagaccttagtgtctgtttttttatGCGTTCACC CatttataatccacCGCATATGATGTAAAGCAAGgttgatatgtggaggaatgcttcc a" /listShort="cotM, S666, S664, yneK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1756661 /Source="Nicolas_upshifts" /id="U1453" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=1243 /SigmaFactorBS="aatcattcgcatcgttgcgttttgaatggTTCATggaagcat tCCTCCACATATCAACcttgctttacatcatatgcggtggattataaatgggtgaacg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1756674) /Source="Nicolas_upshifts" /id="U1454" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1290 /SigmaFactorBS="aagaaaagcagaccttagtgtctgtttttttatGCGTTCACC CatttataatccacCGCATATGATGTAAAGCAAGgttgatatgtggaggaatgcttcc a" /listShort="cotM, S666, S664, yneK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1756692..1756701) /Source="Nicolas_upshift_promotors" /id="U1454" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1290 /SigmaFactorBS="aagaaaagcagaccttagtgtctgtttttttatGCGTTCACC CatttataatccacCGCATATGATGTAAAGCAAGgttgatatgtggaggaatgcttcc a" /listShort="cotM, S666, S664, yneK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1756733..1756879) /gene="sspP" /locus_tag="BSU_17980" /old_locus_tag="BSU17980" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10806362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10806362; Product type f: factor" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="NP_389681.1" /db_xref="EnsemblGenomes-Gn:BSU17980" /db_xref="EnsemblGenomes-Tr:CAB13682" /db_xref="GOA:P71032" /db_xref="InterPro:IPR012614" /db_xref="SubtiList:BG11921" /db_xref="UniProtKB/Swiss-Prot:P71032" /translation="MTNKNTSKDMHKNAPKGHNPGQPEPLSGSKKVKNRNHTRQKHNS SHDM*" /label="sspP CDS" gene complement(1756733..1756879) /gene="sspP" /locus_tag="BSU_17980" /old_locus_tag="BSU17980" /label="sspP gene" downshifts complement(1756754) /Source="Nicolas_upshifts" /id="D982" /incds=0 /nref=42 /ntot=61 /MaxReadThrough="1.80349" /MaxDrop="6.88836" /score="0.778507843" /energy="-4.3" /TU="NA" /idTUdmin="U1456" /TUdmin=5 /isTUend="TRUE" /label="downshifts" CDS complement(1756911..1757057) /gene="sspO" /locus_tag="BSU_17990" /old_locus_tag="BSU17990" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9852018, 10806362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9852018, 10806362; Product type s: structure" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="NP_389682.1" /db_xref="EnsemblGenomes-Gn:BSU17990" /db_xref="EnsemblGenomes-Tr:CAB13683" /db_xref="GOA:P71031" /db_xref="InterPro:IPR012613" /db_xref="SubtiList:BG11920" /db_xref="UniProtKB/Swiss-Prot:P71031" /translation="MVKRKANHVINGMNDAKSQGKGAGYIENDQLVLTEAERQNNKKR KTNQ*" /label="sspO CDS" gene complement(1756911..1757057) /gene="sspO" /locus_tag="BSU_17990" /old_locus_tag="BSU17990" /label="sspO gene" S_feature 1757057..1757190 /Source="Nicolas_S_feature" /locus_tag="new_1926452_1926585" /HighExp="S8, S7, S3, S6, LoTm, S4, S5, BT, Pyr, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S667" upshifts 1757057 /Source="Nicolas_upshifts" /id="U1455" /multdbtbs="-" /comp="M19" /sig="Sig-" /pcomp="0.228771228771229" /psig="0.312687312687313" /xcortree=1215 /SigmaFactorBS="tgccttggctttttgcgtcattcattccgttaatgacgtgat tcgcttttcttttgaccatcattatcaccTCAatcataatatggcttcttttattgtg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 1757068..1757070 /Source="Nicolas_upshift_promotors" /id="U1455" /multdbtbs="-" /comp="M19" /sig="Sig-" /pcomp="0.228771228771229" /psig="0.312687312687313" /xcortree=1215 /SigmaFactorBS="tgccttggctttttgcgtcattcattccgttaatgacgtgat tcgcttttcttttgaccatcattatcaccTCAatcataatatggcttcttttattgtg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(1757073..1757084) /Source="Nicolas_upshift_promotors" /id="U1456" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=837 /SigmaFactorBS="ttatgagaaaaatgtaccggtaatttttactgtttacgctct CTCATATaacacaataaaagaAGCCATATTATGattgaggtgataatgatggtcaaaa g" /listShort="sspO, sspP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1757087) /Source="Nicolas_upshifts" /id="U1456" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=837 /SigmaFactorBS="ttatgagaaaaatgtaccggtaatttttactgtttacgctct CTCATATaacacaataaaagaAGCCATATTATGattgaggtgataatgatggtcaaaa g" /listShort="sspO, sspP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1757099..1757105) /Source="Nicolas_upshift_promotors" /id="U1456" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=837 /SigmaFactorBS="ttatgagaaaaatgtaccggtaatttttactgtttacgctct CTCATATaacacaataaaagaAGCCATATTATGattgaggtgataatgatggtcaaaa g" /listShort="sspO, sspP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1757180..1757187 /Source="Nicolas_upshift_promotors" /id="U1457" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.956043956043956" /psig=1 /xcortree=2774 /SigmaFactorBS="tacatttttctcataagtcgaacttattgtatttaataaaaa cattgaTATTTACTtatgtatgattttgTTTTAATATGAAATTGTGAGaaaattgtga t" /listShort="S668, citB, S669, yneN, ynzL, sspN, tlp" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1757192..1757284 /Source="Nicolas_S_feature" /locus_tag="new_1926587_1926679" /HighExp="B60, M40t90, T0.0H, HiOs, T4.0H, T5.0H, T2.30H, M0t90, Sw, T-1.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigEF" /TUlongPSig="0.994" /label="S668" upshifts 1757192 /Source="Nicolas_upshifts" /id="U1457" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.956043956043956" /psig=1 /xcortree=2774 /SigmaFactorBS="tacatttttctcataagtcgaacttattgtatttaataaaaa cattgaTATTTACTtatgtatgattttgTTTTAATATGAAATTGTGAGaaaattgtga t" /listShort="S668, citB, S669, yneN, ynzL, sspN, tlp" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1757202..1757221 /Source="Nicolas_upshift_promotors" /id="U1457" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.956043956043956" /psig=1 /xcortree=2774 /SigmaFactorBS="tacatttttctcataagtcgaacttattgtatttaataaaaa cattgaTATTTACTtatgtatgattttgTTTTAATATGAAATTGTGAGaaaattgtga t" /listShort="S668, citB, S669, yneN, ynzL, sspN, tlp" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(1757243) /Source="Nicolas_upshifts" /id="D983" /incds=0 /nref=1 /ntot=67 /MaxReadThrough="2.77282" /MaxDrop="4.02811" /score="0.778507843" /energy="-4.3" /TU="NA" /idTUdmin="U1458" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 1757285..1760014 /gene="citB" /locus_tag="BSU_18000" /old_locus_tag="BSU18000" /EC_number="4.2.1.3" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9642180, 10468622, 10656796, 14636591, 16395550, 16923907, 22720735, 23354745" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9642180, 10468622, 10656796, 14636591, 16395550, 16923907, 22720735, 23354745; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aconitate hydratase (bifunctional aconitase)" /protein_id="NP_389683.1" /db_xref="EnsemblGenomes-Gn:BSU18000" /db_xref="EnsemblGenomes-Tr:CAB13684" /db_xref="GOA:P09339" /db_xref="InterPro:IPR000573" /db_xref="InterPro:IPR001030" /db_xref="InterPro:IPR006249" /db_xref="InterPro:IPR015928" /db_xref="InterPro:IPR015931" /db_xref="InterPro:IPR015932" /db_xref="InterPro:IPR018136" /db_xref="InterPro:IPR036008" /db_xref="SubtiList:BG10478" /db_xref="UniProtKB/Swiss-Prot:P09339" /translation="MANEQKTAAKDVFQARKTFTTNGKTYHYYSLKALEDSGIGKVSK LPYSIKVLLESVLRQVDGFVIKKEHVENLAKWGTAELKDIDVPFKPSRVILQDFTGVP AVVDLASLRKAMAAVGGDPDKINPEIPVDLVIDHSVQVDKAGTEDALAVNMDLEFERN AERYKFLSWAKKAFNNYQAVPPATGIVHQVNLEFLASVVHAIEEDGELVTYPDTLVGT DSHTTMINGIGVLGWGVGGIEAEAGMLGQPSYFPVPEVIGAKLVGKLPNGTTATDLAL KVTQVLREKGVVGKFVEFFGPGIAELPLADRATIANMAPEYGATCGFFPVDEEALNYL RLTGRDPEHIDVVEAYCRSNGLFYTPDAEDPQFTDVVEIDLSQIEANLSGPKRPQDLI PLSAMQETFKKQLVSPAGNQGFGLNAEEENKEIKFKLLNGEETVMKTGAIAIAAITSC TNTSNPYVLIGAGLVAKKAVELGLKVPNYVKTSLAPGSKVVTGYLVNSGLLPYMKELG FNLVGYGCTTCIGNSGPLSPEIEEAVAKNDLLITSVLSGNRNFEGRIHPLVKGNYLAS PPLVVAYALAGTVNINLKTDPIGVGKDGQNVYFNDIWPSMDEINALVKQTVTPELFRK EYETVFDDNKRWNEIETTDEALYKWDNDSTYIQNPPFFEEMSVEPGKVEPLKGLRVVG KFGDSVTTDHISPAGAIGKDTPAGKYLQEKGVSPRDFNSYGSRRGNHEVMMRGTFANI RIKNQIAPGTEGGFTTYWPTGEVTSIYDACMKYKEDKTGLVVLAGKDYGMGSSRDWAA KGTNLLGIRTVIAESFERIHRSNLVFMGVLPLQFKQGENADTLGLTGKEVIEVDVDET VRPRDLVTVRAINEDGNVTTFEAVVRFDSEVEIDYYRHGGILQMVLREKMKQS*" /label="citB CDS" gene 1757285..1760014 /gene="citB" /locus_tag="BSU_18000" /old_locus_tag="BSU18000" /label="citB gene" misc_feature complement(1757305..1757309) /Source="Nicolas_upshift_promotors" /id="U1458" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95104895104895" /psig="0.001998001998002" /xcortree=88 /SigmaFactorBS="agtaatgatatgttttcccatttgtagtaaacgtttttctcg cttggaaaacgtcttttgCTGCAgttttttgctcgtttgccattctccaaaatccccc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1757309) /Source="Nicolas_upshifts" /id="U1458" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95104895104895" /psig="0.001998001998002" /xcortree=88 /SigmaFactorBS="agtaatgatatgttttcccatttgtagtaaacgtttttctcg cttggaaaacgtcttttgCTGCAgttttttgctcgtttgccattctccaaaatccccc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature 1760015..1760085 /Source="Nicolas_S_feature" /locus_tag="new_1929410_1929480" /HighExp="M9-stat, B60, M40t90, Glucon, M0t90, MG-0.2, Mal, T2.30H, MG-0.1, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigEF" /TUlongPSig="0.994" /label="S669" CDS 1760086..1760598 /gene="yneN" /locus_tag="BSU_18010" /old_locus_tag="BSU18010" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15342593; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane-bound proteins with a thioredoxin-like domain" /protein_id="NP_389684.1" /db_xref="EnsemblGenomes-Gn:BSU18010" /db_xref="EnsemblGenomes-Tr:CAB13685" /db_xref="GOA:O31820" /db_xref="InterPro:IPR000866" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG13451" /db_xref="UniProtKB/Swiss-Prot:O31820" /translation="MLKKWLAGILLIMLVGYTGWNLYQTYSKKEVGIQEGQQAPDFSL KTLSGEKSSLQDAKGKKVLLNFWATWCKPCRQEMPAMEKLQKEYADKLAVVAVNFTSA EKSEKQVRAFADTYDLTFPILIDKKGINADYNVMSYPTTYILDEKGVIQDIHVGTMTK KEMEQKLDLD*" /label="yneN CDS" gene 1760086..1760598 /gene="yneN" /locus_tag="BSU_18010" /old_locus_tag="BSU18010" /label="yneN gene" downshifts 1760555 /Source="Nicolas_upshifts" /id="D984" /incds=0 /nref=115 /ntot=218 /MaxReadThrough="3.76369" /MaxDrop="5.09954" /score="13.5401842" /energy="-6.9" /TU="U1457" /idTUdmin="U1457" /TUdmin="-726" /isTUend="FALSE" /label="downshifts" promotor_-35 1760624..1760630 /Source="Nicolas_upshift_promotors" /id="U1459" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.715284715284715" /psig="0.715284715284715" /xcortree=1010 /SigmaFactorBS="actggatcttgattagattcagttttttttatactcaaataT GCTTACaagttttcagaattGGAAAAAATAAAagaatatgcggaggtgagaagcgtga a" /listShort="ynzL, sspN, tlp" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1760643 /Source="Nicolas_upshifts" /id="U1459" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.715284715284715" /psig="0.715284715284715" /xcortree=1010 /SigmaFactorBS="actggatcttgattagattcagttttttttatactcaaataT GCTTACaagttttcagaattGGAAAAAATAAAagaatatgcggaggtgagaagcgtga a" /listShort="ynzL, sspN, tlp" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1760645..1760656 /Source="Nicolas_upshift_promotors" /id="U1459" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.715284715284715" /psig="0.715284715284715" /xcortree=1010 /SigmaFactorBS="actggatcttgattagattcagttttttttatactcaaataT GCTTACaagttttcagaattGGAAAAAATAAAagaatatgcggaggtgagaagcgtga a" /listShort="ynzL, sspN, tlp" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1760679..1760804 /gene="ynzL" /locus_tag="BSU_18019" /old_locus_tag="BSU18019" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097732.1" /db_xref="EnsemblGenomes-Gn:BSU18019" /db_xref="EnsemblGenomes-Tr:CAX52626" /db_xref="InterPro:IPR025004" /db_xref="UniProtKB/Swiss-Prot:C0H418" /translation="MKKMRKRSFHELVMENKKELMTNTEYLNQLEEKLEQRFKQK*" /label="ynzL CDS" gene 1760679..1760804 /gene="ynzL" /locus_tag="BSU_18019" /old_locus_tag="BSU18019" /label="ynzL gene" downshifts complement(1760697) /Source="Nicolas_upshifts" /id="D985" /incds=0 /nref=1 /ntot=8 /MaxReadThrough="3.12259" /MaxDrop="3.48183" /score="-0.0160782027" /energy="-13.9" /TU="NA" /idTUdmin="U1462" /TUdmin=1298 /isTUend="FALSE" /label="downshifts" promotor_-35 1760818..1760824 /Source="Nicolas_upshift_promotors" /id="U1460" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.844155844155844" /psig="0.844155844155844" /xcortree=843 /SigmaFactorBS="gaacagcgatttaagcaaaaataacctttaatttgtaTTCAT GTttacccctccttttGAGAAACCTATCtgttgaggagggataaacatgggaaacaac a" /listShort="sspN, tlp" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1760839..1760850 /Source="Nicolas_upshift_promotors" /id="U1460" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.844155844155844" /psig="0.844155844155844" /xcortree=843 /SigmaFactorBS="gaacagcgatttaagcaaaaataacctttaatttgtaTTCAT GTttacccctccttttGAGAAACCTATCtgttgaggagggataaacatgggaaacaac a" /listShort="sspN, tlp" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1760841 /Source="Nicolas_upshifts" /id="U1460" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.844155844155844" /psig="0.844155844155844" /xcortree=843 /SigmaFactorBS="gaacagcgatttaagcaaaaataacctttaatttgtaTTCAT GTttacccctccttttGAGAAACCTATCtgttgaggagggataaacatgggaaacaac a" /listShort="sspN, tlp" /GFF_Attribute="listLong" /label="upshifts" CDS 1760869..1761015 /gene="sspN" /locus_tag="BSU_18020" /old_locus_tag="BSU18020" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10333516" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10333516; Product type f: factor" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="YP_054579.2" /db_xref="EnsemblGenomes-Gn:BSU18020" /db_xref="EnsemblGenomes-Tr:CAE01455" /db_xref="GOA:Q7WY69" /db_xref="InterPro:IPR012612" /db_xref="SubtiList:BG14179" /db_xref="UniProtKB/Swiss-Prot:Q7WY69" /translation="MGNNKKNGQPQYAPSHLGTKPVKYKANKGEKMHDTSGQRPIIMQ TKGE*" /label="sspN CDS" gene 1760869..1761015 /gene="sspN" /locus_tag="BSU_18020" /old_locus_tag="BSU18020" /label="sspN gene" CDS 1761052..1761303 /gene="sspT" /locus_tag="BSU_18030" /old_locus_tag="BSU18030" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10333516" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10333516; Product type f: factor" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein (thioredoxin-like protein)" /protein_id="NP_389685.1" /db_xref="EnsemblGenomes-Gn:BSU18030" /db_xref="EnsemblGenomes-Tr:CAB13686" /db_xref="GOA:Q45060" /db_xref="InterPro:IPR017524" /db_xref="SubtiList:BG11806" /db_xref="UniProtKB/Swiss-Prot:Q45060" /translation="MTKNQNQYQQPNPDDRSDNVEKLQDMVQNTIENIEEAEASMEFA SGEDKQRIKEKNARREQSIEAFRNEIQDESAARQNGYRS*" /label="sspT CDS" gene 1761052..1761303 /gene="sspT" /locus_tag="BSU_18030" /old_locus_tag="BSU18030" /label="sspT gene" downshifts 1761281 /Source="Nicolas_upshifts" /id="D986" /incds=0 /nref=41 /ntot=49 /MaxReadThrough="2.07653" /MaxDrop="7.06685" /score="32.1193211" /energy="-7" /TU="NA" /idTUdmin="U1457" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1761324..1761329 /Source="Nicolas_upshift_promotors" /id="U1461" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.68031968031968" /psig=1 /xcortree=2003 /SigmaFactorBS="acggataccgttcttaaaaaaccagggaaacctggttTTTTT CtttctgatttgatTATGGTAAAATGGGGCTAAAttgacgttaagggagcagagtaat c" /listShort="S670, yneP, yneQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1761343..1761362 /Source="Nicolas_upshift_promotors" /id="U1461" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.68031968031968" /psig=1 /xcortree=2003 /SigmaFactorBS="acggataccgttcttaaaaaaccagggaaacctggttTTTTT CtttctgatttgatTATGGTAAAATGGGGCTAAAttgacgttaagggagcagagtaat c" /listShort="S670, yneP, yneQ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1761347..1761438 /Source="Nicolas_S_feature" /locus_tag="new_1930742_1930833" /HighExp="Etha, dia5, dia15, Diami, H2O2, G180, Salt, G150, BMM, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S670" upshifts 1761347 /Source="Nicolas_upshifts" /id="U1461" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.68031968031968" /psig=1 /xcortree=2003 /SigmaFactorBS="acggataccgttcttaaaaaaccagggaaacctggttTTTTT CtttctgatttgatTATGGTAAAATGGGGCTAAAttgacgttaagggagcagagtaat c" /listShort="S670, yneP, yneQ" /GFF_Attribute="listLong" /label="upshifts" CDS 1761439..1761804 /gene="yneP" /locus_tag="BSU_18040" /old_locus_tag="BSU18040" /EC_number="3.1.2.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11959124, 11994151, 16294310, 18338382; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acyl-CoA thioesterase" /protein_id="YP_054580.1" /db_xref="EnsemblGenomes-Gn:BSU18040" /db_xref="EnsemblGenomes-Tr:CAB13687" /db_xref="GOA:Q45061" /db_xref="InterPro:IPR006683" /db_xref="InterPro:IPR006684" /db_xref="InterPro:IPR029069" /db_xref="SubtiList:BG11823" /db_xref="UniProtKB/Swiss-Prot:Q45061" /translation="MGIVYHANYLVWMEVGRTALIKDLGFLYSDMEKKGVLSPVVDIN ISYKKPLHYGETAVVHTWIEDYNGFKTVYGYHIYNPAGELSIKATSSHICVDKESFKP IQFRKAFPDWHTAYEKAKK*" /label="yneP CDS" gene 1761439..1761804 /gene="yneP" /locus_tag="BSU_18040" /old_locus_tag="BSU18040" /label="yneP gene" CDS 1761820..1762119 /gene="yneQ" /locus_tag="BSU_18050" /old_locus_tag="BSU18050" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389687.1" /db_xref="EnsemblGenomes-Gn:BSU18050" /db_xref="EnsemblGenomes-Tr:CAB13688" /db_xref="SubtiList:BG11824" /db_xref="UniProtKB/Swiss-Prot:Q45062" /translation="MAFGVKREELNRWKQAVKRGEIAFLTHYWLDDRFPEAKTVTKAG CADIDKLVQWGAAYGLKKEWIHKKSEFPHFDLLGETQKYILEQENLTDHLIRFHL*" /label="yneQ CDS" gene 1761820..1762119 /gene="yneQ" /locus_tag="BSU_18050" /old_locus_tag="BSU18050" /label="yneQ gene" downshifts 1762095 /Source="Nicolas_upshifts" /id="D987" /incds=0 /nref=55 /ntot=217 /MaxReadThrough="3.04989" /MaxDrop="5.5978" /score="-4.41102273" /energy="-6" /TU="NA" /idTUdmin="U1461" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1762150..1762437) /gene="yneR" /locus_tag="BSU_18060" /old_locus_tag="BSU18060" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22333191, 23176286" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389688.1" /db_xref="EnsemblGenomes-Gn:BSU18060" /db_xref="EnsemblGenomes-Tr:CAB13689" /db_xref="InterPro:IPR000361" /db_xref="InterPro:IPR008326" /db_xref="InterPro:IPR035903" /db_xref="SubtiList:BG11825" /db_xref="UniProtKB/Swiss-Prot:Q45063" /translation="MNMTINEDALNWYKEELDLESGDQVRFFVRYGGCSNVQKGFSLG VAKDAPQEAGVTAEADGITFFIEESDLWYFDNHDLLVSYSEDADEPVFEYQ*" /label="yneR CDS" gene complement(1762150..1762437) /gene="yneR" /locus_tag="BSU_18060" /old_locus_tag="BSU18060" /label="yneR gene" downshifts complement(1762171) /Source="Nicolas_upshifts" /id="D988" /incds=0 /nref=216 /ntot=260 /MaxReadThrough="3.77766" /MaxDrop="7.20006" /score="-5.4451498" /energy="-6" /TU="U1462,U1463" /idTUdmin="U1463" /TUdmin="-154" /isTUend="FALSE" /label="downshifts" downshifts complement(1762237) /Source="Nicolas_upshifts" /id="D989" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="7.5674" /MaxDrop="3.11178" /score="-5.4451498" /energy="-6" /TU="U1462,U1463" /idTUdmin="U1463" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1762467..1762486) /Source="Nicolas_upshift_promotors" /id="U1462" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.755244755244755" /psig="0.999000999001" /xcortree=2062 /SigmaFactorBS="gtaaaatggttataagcttaaaaaacttctCTTTTGACacag aatagcctaatACGTTTATAATAGAGAAAATtcaaatgaagaacaaaggggtgttctg t" /listShort="yneR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1762479) /Source="Nicolas_upshifts" /id="U1462" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.755244755244755" /psig="0.999000999001" /xcortree=2062 /SigmaFactorBS="gtaaaatggttataagcttaaaaaacttctCTTTTGACacag aatagcctaatACGTTTATAATAGAGAAAATtcaaatgaagaacaaaggggtgttctg t" /listShort="yneR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1762502..1762509) /Source="Nicolas_upshift_promotors" /id="U1462" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.755244755244755" /psig="0.999000999001" /xcortree=2062 /SigmaFactorBS="gtaaaatggttataagcttaaaaaacttctCTTTTGACacag aatagcctaatACGTTTATAATAGAGAAAATtcaaatgaagaacaaaggggtgttctg t" /listShort="yneR" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1762525..1763106) /gene="plsY" /locus_tag="BSU_18070" /old_locus_tag="BSU18070" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15849754, 16850406, 16949372, 17005971, 17308305, 17557823, 17645809, 19282621, 26644587" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15849754, 16850406, 16949372, 17005971, 17308305, 17557823, 17645809, 19282621, 26644587; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acylphosphate:glycerol-3-phosphate O-acyltransferase" /protein_id="NP_389689.1" /db_xref="EnsemblGenomes-Gn:BSU18070" /db_xref="EnsemblGenomes-Tr:CAB13690" /db_xref="GOA:Q45064" /db_xref="InterPro:IPR003811" /db_xref="SubtiList:BG11826" /db_xref="UniProtKB/Swiss-Prot:Q45064" /translation="MLIALLIILAYLIGSIPSGLIVGKLAKGIDIREHGSGNLGATNA FRTLGVKAGSVVIAGDILKGTLATALPFLMHVDIHPLLAGVFAVLGHVFPIFAKFKGG KAVATSGGVLLFYAPLLFITMVAVFFIFLYLTKFVSLSSMLTGIYTVIYSFFVHDTYL LIVVTLLTIFVIYRHRANIKRIINKTEPKVKWL*" /label="plsY CDS" gene complement(1762525..1763106) /gene="plsY" /locus_tag="BSU_18070" /old_locus_tag="BSU18070" /label="plsY gene" S_feature 1763107..1763237 /Source="Nicolas_S_feature" /locus_tag="new_1932502_1932632" /HighExp="C30, S8, S7, S5, S6, S4, BC, S3, T4.0H, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S671" misc_feature complement(1763132..1763151) /Source="Nicolas_upshift_promotors" /id="U1463" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2140 /SigmaFactorBS="tttgatttgatttgtaagcaaactttacaaaaaaacttatca tcagatcatgacatctCATGTTAAAATAAAAAGAAGggaatttgaaaaaggagaaatg t" /listShort="plsY, yneR" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1763149) /Source="Nicolas_upshifts" /id="U1463" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2140 /SigmaFactorBS="tttgatttgatttgtaagcaaactttacaaaaaaacttatca tcagatcatgacatctCATGTTAAAATAAAAAGAAGggaatttgaaaaaggagaaatg t" /listShort="plsY, yneR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1763222..1763225 /Source="Nicolas_upshift_promotors" /id="U1464" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.52047952047952" /psig="0.998001998001998" /xcortree=3133 /SigmaFactorBS="tttgtaaagtttgcttacaaatcaaatcaaacatgcatcata tTTTGatttctcctgttttgATCGTGTAAAATAAGTGAAAaaggagtgacacacgatg c" /listShort="yneT, S672, parE, parC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1763239 /Source="Nicolas_upshifts" /id="U1464" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.52047952047952" /psig="0.998001998001998" /xcortree=3133 /SigmaFactorBS="tttgtaaagtttgcttacaaatcaaatcaaacatgcatcata tTTTGatttctcctgttttgATCGTGTAAAATAAGTGAAAaaggagtgacacacgatg c" /listShort="yneT, S672, parE, parC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1763241..1763260 /Source="Nicolas_upshift_promotors" /id="U1464" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.52047952047952" /psig="0.998001998001998" /xcortree=3133 /SigmaFactorBS="tttgtaaagtttgcttacaaatcaaatcaaacatgcatcata tTTTGatttctcctgttttgATCGTGTAAAATAAGTGAAAaaggagtgacacacgatg c" /listShort="yneT, S672, parE, parC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1763276..1763683 /gene="yneT" /locus_tag="BSU_18080" /old_locus_tag="BSU18080" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22938038; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyl-CoA-binding protein" /protein_id="NP_389690.1" /db_xref="EnsemblGenomes-Gn:BSU18080" /db_xref="EnsemblGenomes-Tr:CAB13691" /db_xref="GOA:Q45065" /db_xref="InterPro:IPR003781" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11827" /db_xref="UniProtKB/Swiss-Prot:Q45065" /translation="MQNPSKAEIKEILQRSKRIAVVGLSDRPDRTSHMVSKAMQDAGY EIIPVNPTIDEALGVKAVSSLKEIDGPIDIVNVFRRSEQLPGVAEEFLETDAPVFWAQ QGLVNEEAYQMLKEKGRTVIMDLCIKVAHAVTK*" /label="yneT CDS" gene 1763276..1763683 /gene="yneT" /locus_tag="BSU_18080" /old_locus_tag="BSU18080" /label="yneT gene" downshifts 1763679 /Source="Nicolas_upshifts" /id="D990" /incds=0 /nref=63 /ntot=221 /MaxReadThrough="4.35976" /MaxDrop="5.49229" /score="-2.11194139" /energy="-6" /TU="U1464" /idTUdmin="U1461" /TUdmin=1584 /isTUend="FALSE" /label="downshifts" promotor_-35 1763745..1763748 /Source="Nicolas_upshift_promotors" /id="U1465" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.554445554445554" /psig="0.998001998001998" /xcortree=2328 /SigmaFactorBS="taaattcaaggatttttgctttttaattttaagatattGTTT gcgtattacggtgaAACAGATACAATAAAGCTTGaacagctttttttgaataccttgt c" /listShort="S672, parE, parC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1763763..1763782 /Source="Nicolas_upshift_promotors" /id="U1465" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.554445554445554" /psig="0.998001998001998" /xcortree=2328 /SigmaFactorBS="taaattcaaggatttttgctttttaattttaagatattGTTT gcgtattacggtgaAACAGATACAATAAAGCTTGaacagctttttttgaataccttgt c" /listShort="S672, parE, parC" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1763767..1764081 /Source="Nicolas_S_feature" /locus_tag="new_1933162_1933476" /HighExp="H2O2, G150, G180, Etha, Oxctl, LBGexp, dia0, Lbexp, M40t45, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S672" upshifts 1763767 /Source="Nicolas_upshifts" /id="U1465" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.554445554445554" /psig="0.998001998001998" /xcortree=2328 /SigmaFactorBS="taaattcaaggatttttgctttttaattttaagatattGTTT gcgtattacggtgaAACAGATACAATAAAGCTTGaacagctttttttgaataccttgt c" /listShort="S672, parE, parC" /GFF_Attribute="listLong" /label="upshifts" CDS 1764082..1766049 /gene="parE" /locus_tag="BSU_18090" /old_locus_tag="BSU18090" /EC_number="5.99.1.3" /function="16.2: Construct biomass (Anabolism)" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:8969507, 9539793, 12682299, 16267290" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8969507, 9539793, 12682299, 16267290; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="subunit B of DNA topoisomerase IV (ATP-dependent)" /protein_id="NP_389691.2" /db_xref="EnsemblGenomes-Gn:BSU18090" /db_xref="EnsemblGenomes-Tr:CAB13692" /db_xref="GOA:Q59192" /db_xref="InterPro:IPR001241" /db_xref="InterPro:IPR002288" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR005740" /db_xref="InterPro:IPR006171" /db_xref="InterPro:IPR013506" /db_xref="InterPro:IPR013759" /db_xref="InterPro:IPR013760" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR018522" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG11804" /db_xref="UniProtKB/Swiss-Prot:Q59192" /translation="MARKQQFDYNEDAIQVLEGLEAVRKRPGMYIGSTDARGLHHLVY EIVDNSVDEVLAGHGDHIIVKIHKDNSISVQDRGRGMPTGMHKLGKPTPEVILTVLHA GGKFGQGGYKTSGGLHGVGASVVNALSEWLTVTIERDGFVYQQRFENGGKPVTSLEKI GKTKKTGTLTHFKPDPTMFSTTTYNFETLSERLRESAFLLKGLKIELIDERNDQREVF YYENGIEAFVAYLNEEKDVLSEVVSFEGEHHSIEVDFAFQFNDGYSENILSFVNNVRT KDGGTHESGAKTAMTRAFNEYARKVALLKEKDKNLEGTDIREGLSAIISVRIPEELLQ FEGQTKGKLGTSEARSAVDAIVSEQLAYFLEENRDTATLLVKKAIKASQAREAARKAR EEARSGKKRKKSEATLSGKLTPAGSRNPAKNELYLVEGDSAGGSAKQGRDRRFQAVLP LRGKVINTEKAKLADIFKNEEINTIIHAIGGGVGADFSIDDINYDKIIIMTDADTDGA HIQVLLLTFFYRYMKPLIEHGKVFIALPPLYKVSKGSGKKEIIEYAWSDEEMGDVLKK VGKGYTIQRYKGLGEMNADQLWETTMNPESRTLVRVKIDDAARVERRVTTLMGDKVEP RRKWIEKNVAFGLDEESNILENENLSVAEEV*" /label="parE CDS" gene 1764082..1766049 /gene="parE" /locus_tag="BSU_18090" /old_locus_tag="BSU18090" /label="parE gene" CDS 1766053..1768473 /gene="parC" /locus_tag="BSU_18100" /old_locus_tag="BSU18100" /EC_number="5.99.1.3" /function="16.2: Construct biomass (Anabolism)" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:9539793, 12682299, 16267290, 16272394, 24440393" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9539793, 12682299, 16267290, 16272394, 24440393; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="subunit A of DNA topoisomerase IV (ATP-dependent)" /protein_id="NP_389692.2" /db_xref="EnsemblGenomes-Gn:BSU18100" /db_xref="EnsemblGenomes-Tr:CAB13693" /db_xref="GOA:Q45066" /db_xref="InterPro:IPR002205" /db_xref="InterPro:IPR005741" /db_xref="InterPro:IPR006691" /db_xref="InterPro:IPR013757" /db_xref="InterPro:IPR013758" /db_xref="InterPro:IPR013760" /db_xref="InterPro:IPR024946" /db_xref="InterPro:IPR035516" /db_xref="SubtiList:BG11803" /db_xref="UniProtKB/Swiss-Prot:Q45066" /translation="MSQPELFHDLPLEEVIGDRFGRYSKYIIQDRALPDARDGLKPVQ RRILYAMHTDGNTFDKNFRKAAKTVGNVIGNYHPHGDSSVYEAMVRMSQDWKVRNVLI EMHGNNGSIDGDPPAAMRYTEARLSPIASELLRDIDKNTVEFVPNFDDTSKEPVVLPA MFPNLLVNGSTGISAGYATDIPPHHLGEVIDAVIKRIQMPSCSVDELMEVIKGPDFPT GGIIQGVDGIRKAYETGKGKIIIRGKAEIETIRGGREQIVITEIPFEVNKANLVKKMD EFRIDKKVEGISEVRDETDRTGLRVVIELKKEADAKGILNFLYKNTDLQITYNFNMVA IHNRRPMLMSLPSILDAYIGHQKEVVTNRSVYELQKAKDRHHIVEGLMKALSILDEVI ATIRSSSDKRDAKNNLIAKYEFTEPQAEAIVSLQLYRLTNTDITALKEEAEELGKKIE ELESILSNDKKLLKVITNSLKALKKKYADTRRSVIEEKIEEIKINLEVMVASEDVYVT VTKDGYLKRTSQRSFAASNGQDFGMKDTDRMLHQFEMNTTDVLLLFTNKGSYIYCPVH QLPDIRWKDMGQHFSNLITIDRDETIVKAIPIKEFDPSAYLLFFTKNGMVKKTELTHY KAQRYSKALVALNLKGEDELIDVHVTNGESQIFMATHLGYGLWFGEDEVNVVGARAAG VKGINLKEDDFVVSGEILQQSDSIVLFTQRGAVKRMSLSEFEKTSRAKRGVVMLRELK KNPHRVVALFACGLEQRLMAETEKGDRKELQTKELRTNDRYSNGSFFFDEEESGKVTA VWRLHTEQ*" /label="parC CDS" gene 1766053..1768473 /gene="parC" /locus_tag="BSU_18100" /old_locus_tag="BSU18100" /label="parC gene" downshifts 1768453 /Source="Nicolas_upshifts" /id="D991" /incds=0 /nref=227 /ntot=255 /MaxReadThrough="0.556700000000001" /MaxDrop="5.87714" /score="9.15080033" /energy="-14.6" /TU="NA" /idTUdmin="U1465" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1768481..1768670) /Source="Nicolas_S_feature" /locus_tag="new_1937876_1938065_c" /HighExp="LPhT, B60, Etha, B36, Gly, LoTm, Sw, BC, S8, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99806099999999998" /TUshortSig="SigA, SigA, SigK" /TUshortPSig="0.968, 0.994, 0.642" /TUlongSig="NA" /TUlongPSig="NA" /label="S673" CDS complement(1768520..1768696) /gene="ynfCc" /locus_tag="BSU_18109" /old_locus_tag="BSU18109" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved hypothetical protein (C-terminus)" /db_xref="PSEUDO:SOX90559.1" /translation="MFNITRLCNENMRRLLNMLFILRMVILGLFSFTALNLFVWQGIE VIHAVTDLFTNHES*" /label="ynfCc CDS" gene complement(1768520..1768696) /gene="ynfCc" /locus_tag="BSU_18109" /old_locus_tag="BSU18109" /pseudo /label="ynfCc gene" downshifts complement(1768524) /Source="Nicolas_upshifts" /id="D992" /incds=0 /nref=153 /ntot=267 /MaxReadThrough="0.609599999999999" /MaxDrop="7.72532" /score="38.0779167" /energy="-14.6" /TU="NA" /idTUdmin="U1467" /TUdmin=5 /isTUend="TRUE" /label="downshifts" CDS complement(1768671..1769081) /gene="ynfCn" /locus_tag="BSU_18110" /old_locus_tag="BSU18110" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /db_xref="EnsemblGenomes-Gn:BSU18110" /db_xref="EnsemblGenomes-Tr:CAB13694" /db_xref="GOA:Q45067" /db_xref="PSEUDO:CAB13694.1" /db_xref="SubtiList:BG11828" /db_xref="UniProtKB/Swiss-Prot:Q45067" /translation="MDWGIIIKIFSNIKGGGDHLKKVTILKASILFLAIASFHLFSIP HAFDIGHHYKAVADQQEMHEMKAGQNADDEKKSITGAFTLTALWAMAVLLLTAESKST GYSRRRQRKKSFILAKFYQSSYFGKLHVQHHPIM*" /label="ynfCn CDS" gene complement(1768671..1769081) /gene="ynfCn" /locus_tag="BSU_18110" /old_locus_tag="BSU18110" /pseudo /label="ynfCn gene" promotor_-10 complement(1769054..1769073) /Source="Nicolas_upshift_promotors" /id="U1466" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.83016983016983" /psig="0.968031968031968" /xcortree=410 /SigmaFactorBS="tatttttaaatttaataaatcaGGTTTACTtttaggatggat tgGGGTATTATTATAAAAATATtcagtaatattaaaggagggggagatcatttgaaaa a" /listShort="ynfC, S673" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1769057) /Source="Nicolas_upshifts" /id="U1466" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.83016983016983" /psig="0.968031968031968" /xcortree=410 /SigmaFactorBS="tatttttaaatttaataaatcaGGTTTACTtttaggatggat tgGGGTATTATTATAAAAATATtcagtaatattaaaggagggggagatcatttgaaaa a" /listShort="ynfC, S673" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1769088..1769095) /Source="Nicolas_upshift_promotors" /id="U1466" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.83016983016983" /psig="0.968031968031968" /xcortree=410 /SigmaFactorBS="tatttttaaatttaataaatcaGGTTTACTtttaggatggat tgGGGTATTATTATAAAAATATtcagtaatattaaaggagggggagatcatttgaaaa a" /listShort="ynfC, S673" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1769122..1769141) /Source="Nicolas_upshift_promotors" /id="U1467" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.52947052947053" /psig="0.994005994005994" /xcortree=2729 /SigmaFactorBS="cgctaataaaagaagttttcTCTTTCAAaaataagcaaaaag ATATATACTTAACAAAGTTAaatttatttttaaatttaataaatcaggtttactttta g" /listShort="ynfC, S673" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1769123) /Source="Nicolas_upshifts" /id="U1467" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.52947052947053" /psig="0.994005994005994" /xcortree=2729 /SigmaFactorBS="cgctaataaaagaagttttcTCTTTCAAaaataagcaaaaag ATATATACTTAACAAAGTTAaatttatttttaaatttaataaatcaggtttactttta g" /listShort="ynfC, S673" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1769156..1769163) /Source="Nicolas_upshift_promotors" /id="U1467" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.52947052947053" /psig="0.994005994005994" /xcortree=2729 /SigmaFactorBS="cgctaataaaagaagttttcTCTTTCAAaaataagcaaaaag ATATATACTTAACAAAGTTAaatttatttttaaatttaataaatcaggtttactttta g" /listShort="ynfC, S673" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1769170..1769189) /Source="Nicolas_upshift_promotors" /id="U1468" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.642357642357642" /psig="0.642357642357642" /xcortree=722 /SigmaFactorBS="ctaaacaacatatcatttaaaatatgtttTTATTCACACcat aaaccgggtaTACATACGCTAATAAAAGAAgttttctctttcaaaaataagcaaaaag a" /listShort="ynfC, S673" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1769181) /Source="Nicolas_upshifts" /id="U1468" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.642357642357642" /psig="0.642357642357642" /xcortree=722 /SigmaFactorBS="ctaaacaacatatcatttaaaatatgtttTTATTCACACcat aaaccgggtaTACATACGCTAATAAAAGAAgttttctctttcaaaaataagcaaaaag a" /listShort="ynfC, S673" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1769203..1769212) /Source="Nicolas_upshift_promotors" /id="U1468" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.642357642357642" /psig="0.642357642357642" /xcortree=722 /SigmaFactorBS="ctaaacaacatatcatttaaaatatgtttTTATTCACACcat aaaccgggtaTACATACGCTAATAAAAGAAgttttctctttcaaaaataagcaaaaag a" /listShort="ynfC, S673" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1769429..1769434 /Source="Nicolas_upshift_promotors" /id="U1469" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.400599400599401" /psig=1 /xcortree=2601 /SigmaFactorBS="gtaacatctggctatgacaatattcttctcgaaaaaaCTTCC TaattcgtcatatTGTGATATAATAAAACTCGTtatgttaaaaaatctaacatcaaaa t" /listShort="S674, alsT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1769447..1769466 /Source="Nicolas_upshift_promotors" /id="U1469" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.400599400599401" /psig=1 /xcortree=2601 /SigmaFactorBS="gtaacatctggctatgacaatattcttctcgaaaaaaCTTCC TaattcgtcatatTGTGATATAATAAAACTCGTtatgttaaaaaatctaacatcaaaa t" /listShort="S674, alsT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1769452 /Source="Nicolas_upshifts" /id="U1469" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.400599400599401" /psig=1 /xcortree=2601 /SigmaFactorBS="gtaacatctggctatgacaatattcttctcgaaaaaaCTTCC TaattcgtcatatTGTGATATAATAAAACTCGTtatgttaaaaaatctaacatcaaaa t" /listShort="S674, alsT" /GFF_Attribute="listLong" /label="upshifts" S_feature 1769465..1769529 /Source="Nicolas_S_feature" /locus_tag="new_1938860_1938924" /HighExp="Cold, G180, Oxctl, G135, LBGexp, G150, HPh, dia0, Lbexp, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S674" CDS 1769530..1770927 /gene="alsT" /locus_tag="BSU_18120" /old_locus_tag="BSU18120" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 8969507, 12823818, 15849754, 16850406, 22607086; Product type t : transporter" /codon_start=1 /transl_table=11 /product="H+/Na+:nitrogen-donor aminoacid symporter" /protein_id="NP_389694.1" /db_xref="EnsemblGenomes-Gn:BSU18120" /db_xref="EnsemblGenomes-Tr:CAB13695" /db_xref="GOA:Q45068" /db_xref="InterPro:IPR001463" /db_xref="SubtiList:BG11798" /db_xref="UniProtKB/Swiss-Prot:Q45068" /translation="MESFFNSLINIPSDFIWKYLFYILIGLGLFFTIRFGFIQFRYFI EMFRIVGEKPEGNKGVSSMQAFFISAASRVGTGNLTGVALAIATGGPGAVFWMWVVAA VGMASSFVESTLAQLYKVRDGEDFRGGPAYYIQKGLGARWLGIVFAILITVSFGLIFN AVQTNTIAGALDGAFHVNKIVVAIVLAVLTAFIIFGGLKRVVAVSQLIVPVMAGIYIL IALFVVITNITAFPGVIATIVKNALGFEQVVGGGIGGIIVIGAQRGLFSNEAGMGSAP NAAATAHVSHPAKQGFIQTLGVFFDTFIICTSTAFIILLYSVTPKGDGIQVTQAALNH HIGGWAPTFIAVAMFLFAFSSVVGNYYYGETNIEFIKTSKTWLNIYRIAVIAMVVYGS LSGFQIVWDMADLFMGIMALINLIVIALLSNVAYKVYKDYAKQRKQGLDPVFKAKNIP GLKNAETWEDEKQEA*" /label="alsT CDS" gene 1769530..1770927 /gene="alsT" /locus_tag="BSU_18120" /old_locus_tag="BSU18120" /label="alsT gene" downshifts 1770916 /Source="Nicolas_upshifts" /id="D993" /incds=0 /nref=112 /ntot=203 /MaxReadThrough="3.44078" /MaxDrop="5.75319" /score="16.664707" /energy="-14.7" /TU="U1469" /idTUdmin="U1469" /TUdmin="-23" /isTUend="FALSE" /label="downshifts" downshifts 1770961 /Source="Nicolas_upshifts" /id="D994" /incds=0 /nref=1 /ntot=3 /MaxReadThrough="2.22962" /MaxDrop="5.03444" /score="16.664707" /energy="-14.7" /TU="NA" /idTUdmin="U1469" /TUdmin=22 /isTUend="TRUE" /label="downshifts" S_feature complement(1771017..1771763) /Source="Nicolas_S_feature" /locus_tag="new_1940412_1941158_c" /HighExp="S6, S8, S7, S5, BT, C30, B36, S4, LoTm, B60" /AntisenseName="eglS" /AntisenseCor="0.42607634596628102" /AntisenseRegPval="-12.6" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S675" promotor_-35 1771140..1771147 /Source="Nicolas_upshift_promotors" /id="U1470" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.585414585414585" /psig="0.995004995004995" /xcortree=1629 /SigmaFactorBS="ttgacaggcttttaaacctccccaaaacaagaaattaggttG ATAGACAatcatgagaaagATTTTTACAATGAGTTCGTGctcataagaagtgtagagc c" /listShort="eglS" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1771159 /Source="Nicolas_upshifts" /id="U1470" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.585414585414585" /psig="0.995004995004995" /xcortree=1629 /SigmaFactorBS="ttgacaggcttttaaacctccccaaaacaagaaattaggttG ATAGACAatcatgagaaagATTTTTACAATGAGTTCGTGctcataagaagtgtagagc c" /listShort="eglS" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1771160..1771179 /Source="Nicolas_upshift_promotors" /id="U1470" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.585414585414585" /psig="0.995004995004995" /xcortree=1629 /SigmaFactorBS="ttgacaggcttttaaacctccccaaaacaagaaattaggttG ATAGACAatcatgagaaagATTTTTACAATGAGTTCGTGctcataagaagtgtagagc c" /listShort="eglS" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1771230..1772729 /gene="eglS" /locus_tag="BSU_18130" /old_locus_tag="BSU18130" /EC_number="3.2.1.4" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:3024130, 7704256, 7710279, 15139916, 26907762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3024130, 7704256, 7710279, 15139916, 26907762; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endo-1,4-beta-glucanase" /protein_id="NP_389695.2" /db_xref="EnsemblGenomes-Gn:BSU18130" /db_xref="EnsemblGenomes-Tr:CAB13696" /db_xref="GOA:P10475" /db_xref="InterPro:IPR001547" /db_xref="InterPro:IPR001956" /db_xref="InterPro:IPR008965" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR018087" /db_xref="InterPro:IPR036966" /db_xref="PDB:2L8A" /db_xref="PDB:3PZT" /db_xref="PDB:3PZU" /db_xref="PDB:3PZV" /db_xref="SubtiList:BG10437" /db_xref="UniProtKB/Swiss-Prot:P10475" /translation="MKRSISIFITCLLITLLTMGGMIASPASAAGTKTPVAKNGQLSI KGTQLVNRDGKAVQLKGISSHGLQWYGEYVNKDSLKWLRDDWGITVFRAAMYTADGGY IDNPSVKNKVKEAVEAAKELGIYVIIDWHILNDGNPNQNKEKAKEFFKEMSSLYGNTP NVIYEIANEPNGDVNWKRDIKPYAEEVISVIRKNDPDNIIIVGTGTWSQDVNDAADDQ LKDANVMYALHFYAGTHGQFLRDKANYALSKGAPIFVTEWGTSDASGNGGVFLDQSRE WLKYLDSKTISWVNWNLSDKQESSSALKPGASKTGGWRLSDLSASGTFVRENILGTKD STKDIPETPSKDKPTQENGISVQYRAGDGSMNSNQIRPQLQIKNNGNTTVDLKDVTAR YWYKAKNKGQNFDCDYAQIGCGNVTHKFVTLHKPKQGADTYLELGFKNGTLAPGASTG NIQLRLHNDDWSNYAQSGDYSFFKSNTFKTTKKITLYDQGKLIWGTEPN*" /label="eglS CDS" gene 1771230..1772729 /gene="eglS" /locus_tag="BSU_18130" /old_locus_tag="BSU18130" /label="eglS gene" promotor_-10 complement(1771762..1771781) /Source="Nicolas_upshift_promotors" /id="U1471" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1389 /SigmaFactorBS="taccggttccgacaatgatgatgttgtctggatcatttttgC GGATAACTGaaatcacttcttcCGCATATGGTTTAATATCACgcttccagttcacatc a" /listShort="S675" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1771785) /Source="Nicolas_upshifts" /id="U1471" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1389 /SigmaFactorBS="taccggttccgacaatgatgatgttgtctggatcatttttgC GGATAACTGaaatcacttcttcCGCATATGGTTTAATATCACgcttccagttcacatc a" /listShort="S675" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1771795..1771804) /Source="Nicolas_upshift_promotors" /id="U1471" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1389 /SigmaFactorBS="taccggttccgacaatgatgatgttgtctggatcatttttgC GGATAACTGaaatcacttcttcCGCATATGGTTTAATATCACgcttccagttcacatc a" /listShort="S675" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1772677 /Source="Nicolas_upshifts" /id="D995" /incds=0 /nref=1 /ntot=89 /MaxReadThrough="3.59763" /MaxDrop="3.67571" /score="6.04626297" /energy="-10.7" /TU="NA" /idTUdmin="U1470" /TUdmin=1210 /isTUend="FALSE" /label="downshifts" CDS 1772797..1773060 /gene="ynfE" /locus_tag="BSU_18140" /old_locus_tag="BSU18140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389696.1" /db_xref="EnsemblGenomes-Gn:BSU18140" /db_xref="EnsemblGenomes-Tr:CAB13697" /db_xref="InterPro:IPR020302" /db_xref="SubtiList:BG11829" /db_xref="UniProtKB/Swiss-Prot:Q45069" /translation="MDEILKQYMVLYKKMSNMINGPDYPGKEKDIQHQKDQIEVYEKQ LQQGFSTDYDYDVFADSVIKCAYGDMTLEDLEAVYYGLTTPFF*" /label="ynfE CDS" gene 1772797..1773060 /gene="ynfE" /locus_tag="BSU_18140" /old_locus_tag="BSU18140" /label="ynfE gene" downshifts complement(1773319) /Source="Nicolas_upshifts" /id="D996" /incds=0 /nref=4 /ntot=148 /MaxReadThrough="1.78569" /MaxDrop="4.04338" /score="32.2414244" /energy="-12.6" /TU="NA" /idTUdmin="U1472" /TUdmin=6 /isTUend="TRUE" /label="downshifts" CDS complement(1773319..1774587) /gene="xynC" /locus_tag="BSU_18150" /old_locus_tag="BSU18150" /EC_number="3.2.1.136" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17028274, 25355936, 26559526, 28330222" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17028274, 25355936, 26559526, 28330222; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="secreted endo-xylanase" /protein_id="NP_389697.1" /db_xref="EnsemblGenomes-Gn:BSU18150" /db_xref="EnsemblGenomes-Tr:CAB13698" /db_xref="GOA:Q45070" /db_xref="InterPro:IPR001139" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR033452" /db_xref="PDB:3GTN" /db_xref="PDB:3KL0" /db_xref="PDB:3KL3" /db_xref="PDB:3KL5" /db_xref="SubtiList:BG11830" /db_xref="UniProtKB/Swiss-Prot:Q45070" /translation="MIPRIKKTICVLLVCFTMLSVMLGPGATEVLAASDVTVNVSAEK QVIRGFGGMNHPAWAGDLTAAQRETAFGNGQNQLGFSILRIHVDENRNNWYKEVETAK SAVKHGAIVFASPWNPPSDMVETFNRNGDTSAKRLKYNKYAAYAQHLNDFVTFMKNNG VNLYAISVQNEPDYAHEWTWWTPQEILRFMRENAGSINARVIAPESFQYLKNLSDPIL NDPQALANMDILGTHLYGTQVSQFPYPLFKQKGAGKDLWMTEVYYPNSDTNSADRWPE ALDVSQHIHNAMVEGDFQAYVWWYIRRSYGPMKEDGTISKRGYNMAHFSKFVRPGYVR IDATKNPNANVYVSAYKGDNKVVIVAINKSNTGVNQNFVLQNGSASNVSRWITSSSSN LQPGTNLTVSGNHFWAHLPAQSVTTFVVNR*" /label="xynC CDS" gene complement(1773319..1774587) /gene="xynC" /locus_tag="BSU_18150" /old_locus_tag="BSU18150" /label="xynC gene" S_feature complement(1774588..1774717) /Source="Nicolas_S_feature" /locus_tag="new_1943983_1944112_c" /HighExp="Lbstat, BC, M0t90, LBGstat, Sw, T2.0H, M40t90, BI, T1.30H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99419599999999997" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S676" CDS complement(1774718..1776259) /gene="xynD" /locus_tag="BSU_18160" /old_locus_tag="BSU18160" /EC_number="3.2.1.55" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1938968, 17426966, 26559526" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1938968, 17426966, 26559526; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="arabinoxylan arabinofuranohydrolase" /protein_id="NP_389698.1" /db_xref="EnsemblGenomes-Gn:BSU18160" /db_xref="EnsemblGenomes-Tr:CAB13699" /db_xref="GOA:Q45071" /db_xref="InterPro:IPR005084" /db_xref="InterPro:IPR006584" /db_xref="InterPro:IPR006710" /db_xref="InterPro:IPR008979" /db_xref="InterPro:IPR023296" /db_xref="PDB:3C7E" /db_xref="PDB:3C7F" /db_xref="PDB:3C7G" /db_xref="PDB:3C7H" /db_xref="PDB:3C7O" /db_xref="SubtiList:BG11807" /db_xref="UniProtKB/Swiss-Prot:Q45071" /translation="MRKKCSVCLWILVLLLSCLSGKSAYAATSTTIAKHIGNSNPLID HHLGADPVALTYNGRVYIYMSSDDYEYNSNGTIKDNSFANLNRVFVISSADMVNWTDH GAIPVAGANGANGGRGIAKWAGASWAPSIAVKKINGKDKFFLYFANSGGGIGVLTADS PIGPWTDPIGKPLVTPSTPGMSGVVWLFDPAVFVDDDGTGYLYAGGGVPGVSNPTQGQ WANPKTARVIKLGPDMTSVVGSASTIDAPFMFEDSGLHKYNGTYYYSYCINFGGTHPA DKPPGEIGYMTSSSPMGPFTYRGHFLKNPGAFFGGGGNNHHAVFNFKNEWYVVYHAQT VSSALFGAGKGYRSPHINKLVHNADGSIQEVAANYAGVTQISNLNPYNRVEAETFAWN GRILTEKSTAPGGPVNNQHVTSIQNGDWIAVGNADFGAGGARSFKANVASTLGGKIEV RLDSADGKLVGTLNVPSTGGAQTWREIETAVSGATGVHKVFFVFTGTGTGNLFNFDYW QFTQR*" /label="xynD CDS" gene complement(1774718..1776259) /gene="xynD" /locus_tag="BSU_18160" /old_locus_tag="BSU18160" /label="xynD gene" S_feature complement(1776260..1776581) /Source="Nicolas_S_feature" /locus_tag="new_1945655_1945976_c" /HighExp="M0t90, LBGstat, T1.30H, T2.30H, BC, M9-stat, T2.0H, T3.0H, T0.30H, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.25588499999999997" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S677" promotor_-10 complement(1776571..1776590) /Source="Nicolas_upshift_promotors" /id="U1472" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.568431568431568" /psig="0.997002997002997" /xcortree=563 /SigmaFactorBS="ttgtagaatcgaacactaactcctccaaaagtttCTATacac aatttttttaATGATGTAGGATGTTAGATAaagggatatcttggataatgatgtaatc t" /listShort="S677, xynD, S676, xynC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1776582) /Source="Nicolas_upshifts" /id="U1472" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.568431568431568" /psig="0.997002997002997" /xcortree=563 /SigmaFactorBS="ttgtagaatcgaacactaactcctccaaaagtttCTATacac aatttttttaATGATGTAGGATGTTAGATAaagggatatcttggataatgatgtaatc t" /listShort="S677, xynD, S676, xynC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1776605..1776608) /Source="Nicolas_upshift_promotors" /id="U1472" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.568431568431568" /psig="0.997002997002997" /xcortree=563 /SigmaFactorBS="ttgtagaatcgaacactaactcctccaaaagtttCTATacac aatttttttaATGATGTAGGATGTTAGATAaagggatatcttggataatgatgtaatc t" /listShort="S677, xynD, S676, xynC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1776808..1776815 /Source="Nicolas_upshift_promotors" /id="U1473" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.502497502497502" /psig="0.99000999000999" /xcortree=1619 /SigmaFactorBS="cccgctttttcatgttttgttcatattttattaATTGTTTAt tcaacactgtcCGCTATAGTAATCCATATCAacaaatatgactgccactcgcatcttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1776828..1776847 /Source="Nicolas_upshift_promotors" /id="U1473" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.502497502497502" /psig="0.99000999000999" /xcortree=1619 /SigmaFactorBS="cccgctttttcatgttttgttcatattttattaATTGTTTAt tcaacactgtcCGCTATAGTAATCCATATCAacaaatatgactgccactcgcatcttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1776835 /Source="Nicolas_upshifts" /id="U1473" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.502497502497502" /psig="0.99000999000999" /xcortree=1619 /SigmaFactorBS="cccgctttttcatgttttgttcatattttattaATTGTTTAt tcaacactgtcCGCTATAGTAATCCATATCAacaaatatgactgccactcgcatcttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 1776854..1777300 /gene="yngA" /locus_tag="BSU_18170" /old_locus_tag="BSU18170" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 20512483; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative conserved membrane protein possibly involved in arabinogalactan metabolism" /protein_id="NP_389699.1" /db_xref="EnsemblGenomes-Gn:BSU18170" /db_xref="EnsemblGenomes-Tr:CAB13700" /db_xref="GOA:O31821" /db_xref="InterPro:IPR007267" /db_xref="SubtiList:BG13452" /db_xref="UniProtKB/Swiss-Prot:O31821" /translation="MTATRIFYEGRFVTLKEKIKTLGRFCTVGVGNTLIDFGVFFLLT ACHVSYLPAQICSYTAGIVNSYVWNRNWTFCVKRKADGKEIVRFLMINIAASGITFLL LYLFQNCGCSLLVSKLAATIGGMMMNFIGNRIWVFGDSLKNIQDQE*" /label="yngA CDS" gene 1776854..1777300 /gene="yngA" /locus_tag="BSU_18170" /old_locus_tag="BSU18170" /label="yngA gene" CDS 1777307..1778200 /gene="yngB" /locus_tag="BSU_18180" /old_locus_tag="BSU18180" /EC_number="2.7.7.9" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8320212, 20512483; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative UTP-glucose-1-phosphate uridylyltransferase" /protein_id="NP_389700.1" /db_xref="EnsemblGenomes-Gn:BSU18180" /db_xref="EnsemblGenomes-Tr:CAB13701" /db_xref="GOA:O31822" /db_xref="InterPro:IPR005771" /db_xref="InterPro:IPR005835" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG13453" /db_xref="UniProtKB/Swiss-Prot:O31822" /translation="MRKKVRKAVIPAAGLGTRFLPATKAQPKEMLPIVDKPAIQYIVE EAAESGIEDILIITGRNKRSIEDHFDRSAELEFNLREKGKTETLKEMQQIADLANIHY IRQKEPLGLGHAVLCAEHFIGDEPFAVLLGDDIMVSETPALRQLMDVYDVYGTEVVGV QSVLPEDVSKYGIINTSGSQGHVYEVNDLVEKPSPEEAPSEIAVMGRYVLNSSIFSVL KTIGRGAGNEIQLTDALREVCRKEPIHARLLEGNRYDIGDKLGCFKASTEIGLMRPEM RSQLLAYLEDVIKRETKEMLR*" /label="yngB CDS" gene 1777307..1778200 /gene="yngB" /locus_tag="BSU_18180" /old_locus_tag="BSU18180" /label="yngB gene" misc_feature 1777817..1777836 /Source="Nicolas_upshift_promotors" /id="U1474" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2146 /SigmaFactorBS="tggcacagaggttgtcggtgtacagtcagttctccctgagga tgtcagcaaaTATGGTATTATAAATACATCagggtctcaagggcatgtatatgaagtg a" /listShort="yngC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1777825 /Source="Nicolas_upshifts" /id="U1474" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2146 /SigmaFactorBS="tggcacagaggttgtcggtgtacagtcagttctccctgagga tgtcagcaaaTATGGTATTATAAATACATCagggtctcaagggcatgtatatgaagtg a" /listShort="yngC" /GFF_Attribute="listLong" /label="upshifts" CDS 1778273..1778869 /gene="yngC" /locus_tag="BSU_18190" /old_locus_tag="BSU18190" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 20512483; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein, phosphatase or phosphate isomerase" /protein_id="NP_389701.1" /db_xref="EnsemblGenomes-Gn:BSU18190" /db_xref="EnsemblGenomes-Tr:CAB13702" /db_xref="GOA:O31823" /db_xref="InterPro:IPR032816" /db_xref="SubtiList:BG13454" /db_xref="UniProtKB/Swiss-Prot:O31823" /translation="MGSLISEILTWLTNMGYAGIAIGLMIEIIPSEIVLAYGGYMVSE GTIGFIGAIIAGVIGGTIAQIFIYWIGRYGGRPFLDKYGKYLLIKKHHIDMSENWFQK YGAGVVFSARFIPVVRHAISIPAGIARMPFLKFVVLTVLAIIPWSILFVYLGIQLGSQ WDDVENIAGTYTTPIMILAVVVIALYFVIKKRTAIFKR*" /label="yngC CDS" gene 1778273..1778869 /gene="yngC" /locus_tag="BSU_18190" /old_locus_tag="BSU18190" /label="yngC gene" downshifts 1778859 /Source="Nicolas_upshifts" /id="D997" /incds=0 /nref=191 /ntot=259 /MaxReadThrough="1.94273" /MaxDrop="5.58345" /score="15.4353025" /energy="-15" /TU="NA" /idTUdmin="U1474" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1778918..1780117) /gene="nrnB" /locus_tag="BSU_18200" /old_locus_tag="BSU18200" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:19553197, 22262096" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19553197, 22262096; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="oligoribonuclease (nanoRNase)" /protein_id="NP_389702.1" /db_xref="EnsemblGenomes-Gn:BSU18200" /db_xref="EnsemblGenomes-Tr:CAB13703" /db_xref="GOA:O31824" /db_xref="SubtiList:BG13455" /db_xref="UniProtKB/Swiss-Prot:O31824" /translation="MYHLYSHNDLDGVGCGIVAKLAFGKDVEIRYNSVNGLNAQVQYF LEKAKESNRQDALFITDLAVNEENEERLNEYVHAGGKVKLIDHHKTALHLNEHEWGFV QVEYDDGRLTSATSLLYGYLIENGFMKPTNALDQFTELVRQYDTWEWERYDQKQAKRL NDLFFLLSIDEFEAKMIQRLSTHDEFFFDDFEEKLLDLEDEKIERYLRRKKREMVQTF VHEHCVGIVHAESYHSELGNRLGKDNPHLDYIAILSMGSKRVSLRTIHDYIDVSEIAG RYGGGGHAKASGCSITDEVYELFVAEAFRIDPVRPDAFRNIYNLKGSANGSLYENRAQ MRFFLFPLDNEWNIQINGETQDETFAAFEEAEWFIKRNYAASLVRDEVFVAFLAENLK LANQHRK*" /label="nrnB CDS" gene complement(1778918..1780117) /gene="nrnB" /locus_tag="BSU_18200" /old_locus_tag="BSU18200" /label="nrnB gene" S_feature complement(1780118..1780189) /Source="Nicolas_S_feature" /locus_tag="new_1949513_1949584_c" /HighExp="S5, S7, S4, S8, S6, ferm, nit, LBGstat, T5.0H, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.977" /TUlongSig="NA" /TUlongPSig="NA" /label="S678" promotor_-10 complement(1780177..1780188) /Source="Nicolas_upshift_promotors" /id="U1475" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=933 /SigmaFactorBS="atatatttacaataacaacattatgtcaactaattaccatTG CATAAaacgcttggtttttTAGAATAGTAAAtaaaggctgccgcacctctagcggcaa t" /listShort="S678, yngD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1780189) /Source="Nicolas_upshifts" /id="U1475" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=933 /SigmaFactorBS="atatatttacaataacaacattatgtcaactaattaccatTG CATAAaacgcttggtttttTAGAATAGTAAAtaaaggctgccgcacctctagcggcaa t" /listShort="S678, yngD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1780203..1780209) /Source="Nicolas_upshift_promotors" /id="U1475" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=933 /SigmaFactorBS="atatatttacaataacaacattatgtcaactaattaccatTG CATAAaacgcttggtttttTAGAATAGTAAAtaaaggctgccgcacctctagcggcaa t" /listShort="S678, yngD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1780287..1781822) /gene="ldeE" /locus_tag="BSU_18210" /old_locus_tag="BSU18210" /EC_number="6.4.1.4" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 19935659; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylcrotonoyl-CoA carboxylase subunit (leucinedegradation)" /protein_id="NP_389703.2" /db_xref="EnsemblGenomes-Gn:BSU18210" /db_xref="EnsemblGenomes-Tr:CAB13704" /db_xref="GOA:O31825" /db_xref="InterPro:IPR011762" /db_xref="InterPro:IPR011763" /db_xref="InterPro:IPR029045" /db_xref="InterPro:IPR034733" /db_xref="SubtiList:BG13456" /db_xref="UniProtKB/Swiss-Prot:O31825" /translation="MLMDYEKERTERAERIRKGGAEKYHQSNREKGKLFVRERLSLLF DDDIELEDAFFAECMSDGLPADGVVTAIGKIGGQTVCVMANDSTVKAGSWGAKTVEKI IRIQEIAEKLNCPLIYLVDSAGARITDQINVFPGRRGAGRIFYNQVKLSGRIPQICLL FGPSAAGGAYIPAFCDIVVMVDGNASMYLGSPRMAEMVIGEKVSLEEMGGARMHCSIS GCGDILAETEEEAIQLVRAYLSYFPANFQEKAPIHEKRPPKHFETPLADVIPQNQNAP FDMHELIERVIDEDSFFEIKALFAPELLTGLARIHGQPVGIVANQPKVKGGVLFHDSA DKAAKFITLCDAFHIPLLFLADIPGFMIGTKVEQAGIIRHGAKMISAMSEATVPKLSV IVRKAYGAGLYAMAGPAFEPDCCLALPTAQIAVMGPEAAVNAVYAKKIAELPEEERAA FISSKREEYKEDINIYRLASEMIIDAVIPANSLRDELAKRLKAYMTKEMTFTNRKHPV YPV*" /label="ldeE CDS" gene complement(1780287..1781822) /gene="ldeE" /locus_tag="BSU_18210" /old_locus_tag="BSU18210" /label="ldeE gene" downshifts complement(1780299) /Source="Nicolas_upshifts" /id="D998" /incds=0 /nref=18 /ntot=38 /MaxReadThrough="1.74923" /MaxDrop="5.31437" /score="-1.4478995" /energy="-11.8" /TU="NA" /idTUdmin="U1477" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1781833..1782615) /gene="ldeF" /locus_tag="BSU_18220" /old_locus_tag="BSU18220" /EC_number="4.2.1.18" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 19935659; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylglutaconyl-CoA hydratase (leucine degradation)" /protein_id="NP_389704.1" /db_xref="EnsemblGenomes-Gn:BSU18220" /db_xref="EnsemblGenomes-Tr:CAB13705" /db_xref="GOA:O34893" /db_xref="InterPro:IPR001753" /db_xref="InterPro:IPR014748" /db_xref="InterPro:IPR018376" /db_xref="InterPro:IPR029045" /db_xref="SubtiList:BG13457" /db_xref="UniProtKB/Swiss-Prot:O34893" /translation="MGDSILFTVKNEHMALITLNRPQAANALSAEMLRNLQMIIQEIE FNSNIRCVILTGTGEKAFCAGADLKERIKLKEDQVLESVSLIQRTAALLDALPQPVIA AINGSALGGGLELALACDLRIATEAAVLGLPETGLAIIPGAGGTQRLPRLIGRGKAKE FIYTGRRVTAHEAKEIGLVEHVTAPCDLMPKAEELAAAISANGPIAVRQAKFAINKGL ETDLATGLAIEQKAYEQTIPTKDRREGLQAFQEKRRAVYKGI*" /label="ldeF CDS" gene complement(1781833..1782615) /gene="ldeF" /locus_tag="BSU_18220" /old_locus_tag="BSU18220" /label="ldeF gene" CDS complement(1782636..1783535) /gene="ldeG" /locus_tag="BSU_18230" /old_locus_tag="BSU18230" /EC_number="4.1.3.4" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 16330546, 19935659, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="hydroxymethylglutaryl-CoA lyase (leucine degradation)" /protein_id="NP_389705.1" /db_xref="EnsemblGenomes-Gn:BSU18230" /db_xref="EnsemblGenomes-Tr:CAB13706" /db_xref="GOA:O34873" /db_xref="InterPro:IPR000891" /db_xref="InterPro:IPR013785" /db_xref="PDB:1YDO" /db_xref="SubtiList:BG13458" /db_xref="UniProtKB/Swiss-Prot:O34873" /translation="MPYPKKVTIKEVGPRDGLQNEPVWIATEDKITWINQLSRTGLSY IEITSFVHPKWIPALRDAIDVAKGIDREKGVTYAALVPNQRGLENALEGGINEACVFM SASETHNRKNINKSTSESLHILKQVNNDAQKANLTTRAYLSTVFGCPYEKDVPIEQVI RLSEALFEFGISELSLGDTIGAANPAQVETVLEALLARFPANQIALHFHDTRGTALAN MVTALQMGITVFDGSAGGLGGCPYAPGSSGNAATEDIVYMLEQMDIKTNVKLEKLLSA AKWIEEKMGKPLPSRNLQVFKSS*" /label="ldeG CDS" gene complement(1782636..1783535) /gene="ldeG" /locus_tag="BSU_18230" /old_locus_tag="BSU18230" /label="ldeG gene" CDS complement(1783550..1783771) /gene="lgeHB" /locus_tag="BSU_18239" /old_locus_tag="BSU18239" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type c: carrier" /codon_start=1 /transl_table=11 /product="methylcrotonyl-CoA carboxylase; biotinylated subunit (leucine degradation)" /protein_id="YP_003097733.1" /db_xref="EnsemblGenomes-Gn:BSU18239" /db_xref="EnsemblGenomes-Tr:CAX52627" /db_xref="InterPro:IPR000089" /db_xref="InterPro:IPR011053" /db_xref="PDB:1Z6H" /db_xref="PDB:1Z7T" /db_xref="PDB:2B8F" /db_xref="PDB:2B8G" /db_xref="UniProtKB/Swiss-Prot:C0H419" /translation="MTVSIQMAGNLWKVHVKAGDQIEKGQEVAILESMKMEIPIVADR SGIVKEVKKKEGDFVNEGDVLLELSNSTQ*" /label="lgeHB CDS" gene complement(1783550..1783771) /gene="lgeHB" /locus_tag="BSU_18239" /old_locus_tag="BSU18239" /label="lgeHB gene" CDS complement(1783786..1785120) /gene="ldeHA" /locus_tag="BSU_18240" /old_locus_tag="BSU18240" /EC_number="6.4.1.4" /EC_number="6.3.4.14" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 7915138, 19935659; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="biotin carboxylase for subunit LdeHB of methylcrotonyl-CoA carboxylase" /protein_id="NP_389706.1" /db_xref="EnsemblGenomes-Gn:BSU18240" /db_xref="EnsemblGenomes-Tr:CAB13707" /db_xref="GOA:O34544" /db_xref="InterPro:IPR005479" /db_xref="InterPro:IPR005481" /db_xref="InterPro:IPR005482" /db_xref="InterPro:IPR011054" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR011764" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="SubtiList:BG13459" /db_xref="UniProtKB/Swiss-Prot:O34544" /translation="MFTKVLIANRGEIAMRIIRTCSRLGIKTVAVYSEADKDAPHTKA ATEAYLIGESRVSESYLNIERIIKTAKKAKADAIHPGYGLLSENSRFAERCKQENIVF IGPSPDIIAKMGSKIEARKAMEAAGVPVVPGVSESLGDIEAACRTASQIGYPVMLKAS AGGGGIGMQRVENEEALKKAYEGNKKRAADFFGDGSMYIEKVIEHARHIEVQLLADQH GHTVHLFERDCSVQRRHQKVIEEAPSPFVDDELRMKIGQTAVKAAKAIGYTNAGTIEF IVDQKQNFYFLEMNTRLQVEHPVTEEITGLDLVEQQLRIAAGHTLTFSQKDIQRNGHA IEVRIYAEDPKTFFPSPGTITAFSLPDQKGVRHECAVAKDSTVTPFYDPMIAKMIVKG QTRTEAIEKLETALRDYRVEGIKTNLPLLIQAAATKAFKEGDVTTDFLKQHL*" /label="ldeHA CDS" gene complement(1783786..1785120) /gene="ldeHA" /locus_tag="BSU_18240" /old_locus_tag="BSU18240" /label="ldeHA gene" CDS complement(1785130..1786779) /gene="ldeI" /locus_tag="BSU_18250" /old_locus_tag="BSU18250" /EC_number="6.2.1.16" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12535077, 15213221, 19935659; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetoacetyl-CoA synthetase" /protein_id="NP_389707.1" /db_xref="EnsemblGenomes-Gn:BSU18250" /db_xref="EnsemblGenomes-Tr:CAB13708" /db_xref="GOA:O31826" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="SubtiList:BG13460" /db_xref="UniProtKB/Swiss-Prot:O31826" /translation="MAELIHSTIGRLLEQTADAYPDRDAVVYPDRNIRYTYAQFDSLC RQTAKGLMRMGIGKGDHVAIWASNISEWLAVQFATAKIGAVLVTVNTNYQAHELDYLL KQSDAAALIIMDSYRGTSYPDIVNSLIPELQEAKPGQLKSERYPFLKTLIYIGNKRLS GMYHWDDTEILAKTVTDAELEERMNSLDKDNVINMQYTSGTTGFPKGVMLTHFNVINN AANIAECMALTSQDRMCIPVPFFHCFGCVLGVLACVSVGAAMIPVQEFDPVTVLKTVE KEKCTVLHGVPTMFIAELHHPDFDAYDLSTLRTGIMAGSPCPSEVMKAVIERMGMKDI TIAYGQTEASPVITQTRANDSFIRRVETTGRALPHTEVKIVEPGTCQEVQRGMQGELC TRGYHVMKGYYKDKDATRKAINHDGWLFTGDLAVMDEDGYCRITGRLKDMLIRGGENI YPREIEEFLYQHPAVLDVQVVGVPDAKFGEEAAAWIKLKDGKSVSPDELKAYCKGKIA RHKIPRYVIFTDDYPMTASGKIQKYKLREKTIEMFNLSSSQ*" /label="ldeI CDS" gene complement(1785130..1786779) /gene="ldeI" /locus_tag="BSU_18250" /old_locus_tag="BSU18250" /label="ldeI gene" promotor_no_box 1785179..1785279 /Source="Nicolas_upshift_promotors" /id="U1476" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.287712287712288" /psig="0.174825174825175" /xcortree=1695 /SigmaFactorBS="ttatatttttgaattttgcctgaggccgtcatcggatagtca tccgtaaaaataacataacgcggaattttgtggcgggcgattttccctttgcaatagg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 1785239 /Source="Nicolas_upshifts" /id="U1476" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.287712287712288" /psig="0.174825174825175" /xcortree=1695 /SigmaFactorBS="ttatatttttgaattttgcctgaggccgtcatcggatagtca tccgtaaaaataacataacgcggaattttgtggcgggcgattttccctttgcaatagg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1786823..1787965) /gene="ldeJ" /locus_tag="BSU_18260" /old_locus_tag="BSU18260" /EC_number="1.3.8.4" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 8655474, 17085570, 19935659; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isovaleryl-CoA dehydrogenase (leucine degradation)" /protein_id="NP_389708.1" /db_xref="EnsemblGenomes-Gn:BSU18260" /db_xref="EnsemblGenomes-Tr:CAB13709" /db_xref="GOA:O34421" /db_xref="InterPro:IPR006089" /db_xref="InterPro:IPR006091" /db_xref="InterPro:IPR009075" /db_xref="InterPro:IPR009100" /db_xref="InterPro:IPR013786" /db_xref="InterPro:IPR036250" /db_xref="InterPro:IPR037069" /db_xref="SubtiList:BG13461" /db_xref="UniProtKB/Swiss-Prot:O34421" /translation="MNFELTKEQQMVREMVKDFAKKEIAPHAEHVDQTGEFPMQTFKK MGELGLMGIPFPEEYGGSGGDTISYALAVEEVGKACGSTGLSYAAAVSLGASPLYYFG TEEQKQTHLTPLASGTALGSFGLTEPNAGSDAGGTQTKAISNGDEYVINGEKCWITNA SYARTVIVTAVTGKNKDGKNIISALIVPTDTPGLTITSPYDKMGVRGSNTAEILLEDV RVPAANLLGDPTKGFKQFLYTLDGGRISIAALAVGIAQAALDASLAYAKERKQFGQPI SSFQAIQFKLADMAMEIDLARQMVLKAAWLKDHNRPFTKEAAYAKLFASEMATRACNQ AIQIHGGSGYMKEYGVERMLRDAKLMEIGEGTSEIQRLVIARQLLK*" /label="ldeJ CDS" gene complement(1786823..1787965) /gene="ldeJ" /locus_tag="BSU_18260" /old_locus_tag="BSU18260" /label="ldeJ gene" promotor_-10 complement(1787984..1788002) /Source="Nicolas_upshift_promotors" /id="U1477" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1156 /SigmaFactorBS="aaatgattcagttttaattttcagacttttcttgtcagGGAA TGattatagaactcgccTAATAGGATGTTACAAAGAtgtgaaggaggaaacgatgtga a" /listShort="yngJ, yngI, yngHA, yngHB, yngG, yngF, yngE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1788001) /Source="Nicolas_upshifts" /id="U1477" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1156 /SigmaFactorBS="aaatgattcagttttaattttcagacttttcttgtcagGGAA TGattatagaactcgccTAATAGGATGTTACAAAGAtgtgaaggaggaaacgatgtga a" /listShort="yngJ, yngI, yngHA, yngHB, yngG, yngF, yngE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1788018..1788023) /Source="Nicolas_upshift_promotors" /id="U1477" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1156 /SigmaFactorBS="aaatgattcagttttaattttcagacttttcttgtcagGGAA TGattatagaactcgccTAATAGGATGTTACAAAGAtgtgaaggaggaaacgatgtga a" /listShort="yngJ, yngI, yngHA, yngHB, yngG, yngF, yngE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1788056..1788361) /gene="ynzE" /locus_tag="BSU_18270" /old_locus_tag="BSU18270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389709.1" /db_xref="EnsemblGenomes-Gn:BSU18270" /db_xref="EnsemblGenomes-Tr:CAB13710" /db_xref="GOA:O34356" /db_xref="InterPro:IPR020509" /db_xref="SubtiList:BG13468" /db_xref="UniProtKB/Swiss-Prot:O34356" /translation="MLTDPAEEAFLPNFLLLGAGTALVLCLVFFLYQKLDQSQFAVIK LGIWGSAVGLLMDTISLWNLPLIFPALSKGQVIAFTIWMVCAYCMYLLIPLILSHKK* " /label="ynzE CDS" gene complement(1788056..1788361) /gene="ynzE" /locus_tag="BSU_18270" /old_locus_tag="BSU18270" /label="ynzE gene" CDS complement(1788351..1788524) /locus_tag="BSU_18275" /old_locus_tag="BSU18275" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_009513961.1" /translation="MNMEAVFGHLPLLESEKLVLNKNKIEEKHVQDVFYVFISSLVRC HIIFCAVRRCCVD*" /label="conserved protein of unknown function CDS" gene complement(1788351..1788524) /locus_tag="BSU_18275" /old_locus_tag="BSU18275" /label="gene" CDS complement(1788632..1790164) /gene="yngK" /locus_tag="BSU_18280" /old_locus_tag="BSU18280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10960106; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative exported glycoside hydrolase" /protein_id="NP_389710.1" /db_xref="EnsemblGenomes-Gn:BSU18280" /db_xref="EnsemblGenomes-Tr:CAB13711" /db_xref="InterPro:IPR003790" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR017853" /db_xref="SubtiList:BG13462" /db_xref="UniProtKB/Swiss-Prot:O35015" /translation="MKVCQKSIVRFLVSLIIGTFVISVPFMANAQSDRELRAVWIASV LNIDWPSKKGLSVKEQKQEYIKLLDDVQKMGMNAVIVQIKPTADAFYPSAYGPWSEYL TGVQGKDPGYDPLAFMIEETHKRNLEFHAWFNPYRITMNHTDLNKLSEDHPARKHPDW VAAYGNQLYYHPGIPEARDFIVKGIEEVVKHYDIDAVHMDDYFYPYKIAGQEFPDQAQ YEQYGKDAFSNIDDWRRDNVNQLVKQINQTIKAAKPYVKFGISPFGVWRNAADDPTGS NTKAGVRNYDDLYADTRHWIQEGDIDYIAPQIYWSIGFNAAAYDVLADWWSNEVKNRP VHLYIGQAAYKINNNFDPPWSDPEEYVRQITLNRQLELVKGSMHFSLKDLNKNPLGIK DSLSTDLYSKPALVPQMPWLDNTAPKKPKLTKVTEDKNGNLLQIKDHPSNQKTKETAY YAIYRAEGKKQRTLLATQRKTHEQQTFLDNTADPNKKYTYYVTSADRLHNESKASKRT TK*" /label="yngK CDS" gene complement(1788632..1790164) /gene="yngK" /locus_tag="BSU_18280" /old_locus_tag="BSU18280" /label="yngK gene" downshifts complement(1788643) /Source="Nicolas_upshifts" /id="D999" /incds=0 /nref=7 /ntot=27 /MaxReadThrough="2.27934" /MaxDrop="4.41371" /score="9.43133612" /energy="-8" /TU="NA" /idTUdmin="U1478" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1790199..1790218) /Source="Nicolas_upshift_promotors" /id="U1478" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1335 /SigmaFactorBS="tagtgagatagacattctgTTAATCACCCttttatagcccgG GAATACCGTAATAGCGAATagtgaaagtgatgtaatgggggagaagaaacagaatgaa g" /listShort="yngK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1790199) /Source="Nicolas_upshifts" /id="U1478" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1335 /SigmaFactorBS="tagtgagatagacattctgTTAATCACCCttttatagcccgG GAATACCGTAATAGCGAATagtgaaagtgatgtaatgggggagaagaaacagaatgaa g" /listShort="yngK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1790231..1790240) /Source="Nicolas_upshift_promotors" /id="U1478" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1335 /SigmaFactorBS="tagtgagatagacattctgTTAATCACCCttttatagcccgG GAATACCGTAATAGCGAATagtgaaagtgatgtaatgggggagaagaaacagaatgaa g" /listShort="yngK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1790300..1790692) /gene="yngL" /locus_tag="BSU_18290" /old_locus_tag="BSU18290" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735, 28163698; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_389711.1" /db_xref="EnsemblGenomes-Gn:BSU18290" /db_xref="EnsemblGenomes-Tr:CAB13712" /db_xref="GOA:O34506" /db_xref="InterPro:IPR010773" /db_xref="SubtiList:BG13463" /db_xref="UniProtKB/Swiss-Prot:O34506" /translation="MDRLSFLTFIMLILASYRLTHLIVFDKITEFIRKPFMKKKRIVD QNGHVDEKSVPASNFGYMLNCYWCAGVWCAILIGLGYLFLPRIAIPLIFILAIAGAQA ILETAVGVGVKLIDVLKSLQTMMNDKKS*" /label="yngL CDS" gene complement(1790300..1790692) /gene="yngL" /locus_tag="BSU_18290" /old_locus_tag="BSU18290" /label="yngL gene" downshifts complement(1790331) /Source="Nicolas_upshifts" /id="D1000" /incds=0 /nref=2 /ntot=18 /MaxReadThrough="0.581539999999999" /MaxDrop="2.96298" /score="5.25915686" /energy="-11.4" /TU="NA" /idTUdmin="U1479" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1790720..1790731) /Source="Nicolas_upshift_promotors" /id="U1479" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=852 /SigmaFactorBS="agaggccattctctgtccgtctttctttttgtatcaAGAATG GataagggacacttGGGAATGATAACatcatcctttttcttggaggcttctcaatgga c" /listShort="yngL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1790727) /Source="Nicolas_upshifts" /id="U1479" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=852 /SigmaFactorBS="agaggccattctctgtccgtctttctttttgtatcaAGAATG GataagggacacttGGGAATGATAACatcatcctttttcttggaggcttctcaatgga c" /listShort="yngL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1790745..1790751) /Source="Nicolas_upshift_promotors" /id="U1479" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=852 /SigmaFactorBS="agaggccattctctgtccgtctttctttttgtatcaAGAATG GataagggacacttGGGAATGATAACatcatcctttttcttggaggcttctcaatgga c" /listShort="yngL" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1790803..1794642) /gene="ppsE" /locus_tag="BSU_18300" /old_locus_tag="BSU18300" /EC_number="2.3.1.-" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9889147, 10471562, 12486459, 22720735, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9889147, 10471562, 12486459, 22720735, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nonribosomal plipastatin synthetase E" /protein_id="NP_389712.1" /db_xref="EnsemblGenomes-Gn:BSU18300" /db_xref="EnsemblGenomes-Tr:CAB13713" /db_xref="GOA:O31827" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR001031" /db_xref="InterPro:IPR001242" /db_xref="InterPro:IPR006162" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR010071" /db_xref="InterPro:IPR020459" /db_xref="InterPro:IPR020802" /db_xref="InterPro:IPR020806" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="InterPro:IPR029058" /db_xref="InterPro:IPR036736" /db_xref="SubtiList:BG11962" /db_xref="UniProtKB/Swiss-Prot:O31827" /translation="MKKGADTMNTIKKIKNIYPLSHMQEGMLFHSFLRKEEGAYVEQS LFTIKGSLSYDWFQRSIQAIIDRHDIFRTVFLPHVPHLSGPRQVVMTEREFHLNSEDI SHLPTNDQNEYIERFKEKDKQKGFDLQKDMLMRISLFKTAKDEHVCIWSHHHILMDGW CLGIVMQEFMQIYQSIHAGKPLSLDPVRPYSTYISWLTNRDKEKAAAYWDTYLKNYSA PSPLPRVSDKETKESYHREDLIFSLNKPLTDKLKETAKQHGVTLATLIQAVWGVMLQQ YNRTDDVVFGAVVSGRPSEIPGVEQMIGLFINTIPIRIKTHQDETFHELLIRCQKEML EAEPFTCQPLFDIQANTALKQELIDHIIVFENYPLQQKIADSADQTDSPLQIDQVQVS EQSGYNFNLVVAPGEELVIKFSYNAFVYDAAWISCIKRQFTQALSTAAQHPHMPIADF SFLDATEKEQIVTQFNNTKTEYPKNHTIIDLFREQAEKTPDHTALVYGNMSISYKELD KRSNALARELIQKGFRKNETAGILAAHSPEFMISVLAVLKAGGAYLPLDAELPPERVS FMLEETQAKMLIVQKGLEQNAAFSGTCIISDAQGLMEENDIPINISSSPDDLAYIMYT SGSTGRPKGVMITNRNVVSLVRNSNYTSASGDDRFIMTGSISFDAVTFEMFGALLNGA SLHIIDKSTMLTPDRFGAYLLENDITVLFLTTALFNQLAQVRADMFRGLHTLYVGGEA LSPALMNAVRHACPDLALHNIYGPTENTTFSTFFEMKRDYAGPIPIGKPISNSTAYIL DTKGRLLPIGVPGELCVGGDGVAKGYLNRVDLTNAVFSPHPFLPGERIYRTGDLARWL PDGNLEYISRIDRQMKIRGKRIEPAEIEARLLEMEGVQEAAVTLREKDGEAQLYTHYV GDHKKTDTDFRADLARVLPDYMIPQHWVRVERMPLTGNGKIDRSALPIPENKPAKRQN IILPRNLVEEELANIWKQVLGVNTISIDDDFFAIGGHSLRALQVIHTLKHQQNIDIPI DFLFEHPTIAQLAEKLYSKQLTAANEQHVIKLNQHGAQNLFCFPPISGFGIYFKDLAL LLNEKAAVYGFHFIEQDTRIEQYVNCMTDIQPEGPYVLLGYSAGGNLAFEVAQAMERK GLEVSDFIIVDAYLKEQPLPIDTGNDESAAYLPEAVREKVMKKKRNYQEYWAQLLNEG HIKASIHFIEAGIHPETSGHTGLTKWEGACGNYSEYTGFGAHKDMLEGTYAEKNADII LDILEKITSNQVILHKR*" /label="ppsE CDS" gene complement(1790803..1794642) /gene="ppsE" /locus_tag="BSU_18300" /old_locus_tag="BSU18300" /label="ppsE gene" downshifts complement(1790815) /Source="Nicolas_upshifts" /id="D1001" /incds=0 /nref=51 /ntot=190 /MaxReadThrough="0.85603" /MaxDrop="4.50208" /score="20.3407616" /energy="-16.7" /TU="NA" /idTUdmin="U1479" /TUdmin="-484" /isTUend="FALSE" /label="downshifts" CDS complement(1794650..1805461) /gene="ppsD" /locus_tag="BSU_18310" /old_locus_tag="BSU18310" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9889147, 10471562, 16707694, 26284661, 28477175" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9889147, 10471562, 16707694, 26284661, 28477175; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nonribosomal plipastatin synthetase D involved in synthesis of plipastatin" /protein_id="NP_389713.2" /db_xref="EnsemblGenomes-Gn:BSU18310" /db_xref="EnsemblGenomes-Tr:CAB13714" /db_xref="GOA:P94459" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR001242" /db_xref="InterPro:IPR006162" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR010060" /db_xref="InterPro:IPR010071" /db_xref="InterPro:IPR013321" /db_xref="InterPro:IPR020806" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="InterPro:IPR036736" /db_xref="SubtiList:BG11961" /db_xref="UniProtKB/Swiss-Prot:P94459" /translation="MTKANSIQDIYPLSYMQEGMLFHSLLQKDSQAYVEQASFTIEGK VNPQFFQNSINALVERHDIFRTIFISQNVSSPQQVVLRERNVIVLEEDITHLNEAEQS QFIEQWKEKDRDRGFHLQKDVLMRIALIQTGESQYSCIWTFHHIMMDGWCLSIVLKEF LHIYASYVNASPITLEPVQPYGKYIKWLMEQDKEQAVSYWDHYLSGHEQQTVLPKQKK TKGKSRQEHVTFSFSKEESSRLSELAAREEVTLSTIFHTIWGILLQKYNNNDDAVFGS VISGRPAEIEGIEHMVGLFINTMPVRVQGAKTPFLQLIKDMQKDRLAAEAYSYHPLYE IQSRSAVKQGLIDHILVFENYPVQQEIQMLNKQEHASDLFQIHNFTVADETNYSFYLM VAPGEEIHIKMNYDAEQHDRSFVLSVKEHLLNAVSQILNNPNLPPEEIDITTDTEKRQ LIGEITDQTPVYETIHAMFEKQAEKTPDAHAVIDQACSLTYRELNKAANRLARHLRMK GVVRQEPVAIMMERSAAFITGVLGILKAGGAIVPVDPHYPADRIRYILHDCGCSHVVS QAHLPSSLEDNYIITHPEDIESKVDGSNIKSVNNADDLLYMIYTSGTTGKPKGVQFEH RNMANLLKFEYTHSGIDFEADVLQFATPSFDVCYQEIFSALLKGGTLHIVPEAIKRDV PQLFAFINKHQTNIVFLPTAFIKMIFSERELANSFPDGVKHLIAAGEQLMISDLFQDV LRKRGIHLHNHYGPSETHVVSTYTIHPGDPIPELPPIGKPIGCTDLYILNHQKQLQPC GVPGELYISGASVARGYVNHDKLTSDKFSSDPFKPDVIMYRTGDLARRLEDGNIEYIG RADNQVKIRGYRIEPQEIEVTLMNHPDISEAAILIWQDQNGEHELCAYYCSVQKLNTI DLRSYMASELPEYMIPAKWIWVDSIPLTPNGKVDRAALPEPDASISGNPYTAPRNLLE AKLSQLFEDVLKNGHIGIQDNFFDNGGHSLKATVLMSRIAKEFHVQVSLKDIFAHPTV EGLALIIREAEQNLYAAIEPAEKRDTYPVSSAQKRIYVLQQLDEGVAYNMPAVLELEG ALDVAKLSAVCKELISRHEPLRTSFVSGADDEPVQRIHTEVPFTLSKETTIEGFVRPF DLSQAPLFRAGLIEVSNEKHVLLVDMHHIISDGVSVQLLIREFTDLYANRQLKPLRIQ YKDYAVWQQKFKKGDSYQKQETYWQQQFSGDLPILELPTDKRRPAERQFIGGKVTFQL DKEITARIKRLAHKNRSTLYMTLLALYSAFLSRLSGQDDIVIGSPIAGRPHADLEAVL GMFVNTLALRTRPAGNKTFEEFLKEVRQTALEAYEHQDYPFEELVDKLGVQREMSRNP LFDTTLVLQNMEQQKLKMNDVQLQWNDLEHPISKFDISLYVTEHDSELFCQFEYSTAL FEKETIQRWASLFTTLVEHTAASPETELDNIPILTKEEERDFIESCHLFEETGYSMNQ TLHYALEQQAEKTPDQAAVIFEDGVMTYKELNEQANRIAWELIGRGVKPETTVAIIGK RSPEMLLGIYGILKAGGAYLPIDPDYPEERISFLLEDSGTNILLLQSAGLHVPEFTGE IVYLNQTNSGLAHRLSNPNVDVLPQSLAYVIYTSGSTGMPKGVEIEHRSAVNFLNSLQ SRYQLKHSDMIMHKTSYSFDASIWELFWWPYAGASVYLLPQGGEKEPEVIAKAIEEQK ITAMHFVPSMLHAFLEHIKYRSVPIKTNRLKRVFSGGEQLGTHLVSRFYELLPNVSIT NSYGPTEATVEAAFFDCPPHEKLERIPIGKPVHHVRLYLLNQNQRMLPVGCIGELYIA GAGVARGYLNRPALTEERFLEDPFYPGERMYKTGDVARWLPDGNVEFLGRTDDQVKIR GYRIEPGEIEAALRSIEGVREAAVTVRTDSGEPELCAYVEGLQRNEVRAQLERLLPGY MVPAYMIEMEQWPVTPSGKLDRNALPAPGGAADAETYTAPRNVTEMKLSQLWEDVLKN GPVGIHDNFFDRGGHSLKATALVSRITKEFDVQVPLKDVFAHPTVEGLATVIREGTDS PYEAIKPAEKQETYPVSSAQKRIYVLQQLEDGGTGYNMPAVLELEGKLNPERMDRAFQ ELIKRHESLRTSFEQDEGGDPVQRIHDEVPFTLQTTVLGARTEQEAAAAFIKPFDLSQ APLFRAQIVKVSDERHLLLVDMHHIISDGVSVNILIQEFGELYNNRKLPALRIQYKDY AVWQEGFKTGDAYKMQEAYWLKQLEGELPVLDLPADHARPPVRSFAGDKVSFTLEPEV ASGLHKLARENGSTLYMVLLAAYTAFLSRLSGQEDIIVGSPIAGRPHKDLEPILGMFV NTLALRTRPEGGKPFVQYLQEVRETALEAFEHQNYPFEELVDKLELTRDMSRNPVFDA MLVVQNNDYEPLHLHDLQMKPAQVSHLVSKFDLTLQASEGDGNIHFLFEYSTALFEKT TIERWASHLTNVLSIIGKNPKVTLNHIDILTQEERHQLLNEFNTGQANQYGVQTISQL FEQQAARTPKASALVSGDKTLTYQELDEWSNGIARALRSRGVKPDTPVGIMMHRSFSM IASILGVWKAGGCYVPIDPEYPKERKRYILSDSGTKLLMTINEADLGVLADFEGEILT IESVEEDDKSPLPQMSSAHHLAYIIYTSGTTGRPKGVMVEHKGIANTLQWRRNAYAFN ETDTILQLFSFSFDGFITSMFTPLLSGAKAVLLHEEEAKDILAIKHQLSRQRITHMII VPVLYRALLDVVQPEDVKTLRVVTLAGEAADRELIARSLAICPHTELANEYGPTENSV ATTVMRHMEKQAYVSIGQPIDGTQVLILNSNHQLQPIGVAGELCIAGTGLARGYVNLP ELTERAFTQNPFKPEARMYRTGDAARWMADGTLEYLGRIDDQVKIRGYRVETKEIESV IRCIKGVKDAAVVAHVTASGQTELSAYVVTKPGLSTNAVRSELQNKLPVFMHPAFIEK LDSLPLSPNGKLDRGALPKPVYNHEGERPFLPPSSKMEQILADIWKEVLGAEKIGTAD SFFELGGDSIKALQVSARLHRIGKQMAVKDLFSHPTIQELAAYIRDSDTSSSQAAVEG DVQWSPVQKWFLSQDIKEKHHFNQSVMLHRSTSVQEDALRKTLKAITCHHDALRMVFT QNEQGKWDQYNRPLSHSDDALYGLQMIDLSAPDGTDGNRPYEPLIKRHVLDIQQKMDL KNGPLLQAGLFHTIDGDFLFLSAHHLVVDGISWRVLLEDLALGYRQAAGGEDIKLPPK TSSFKAYAKKLSDYAESQQLMKQLKYWREAEEYQTEALPFDQIDGTRAHEGQRSTISF TLNDKETAALLKDANSAYNTDTQDMLLASVILALRHWTNQSAFKLSLEGHGREDVLKG IDVSRTIGWFTAIYPLLIKLNADLPDSEESMVHVLKTTKDTLRRVPDKGFGYGVIKYL TPPGKKDINFTGAPEISFNYLGQFESGRTAEVPEEDAFSFSPLGAGGDISTTWNREQS LDISAIAAEGKLTVNMTYDNARFQRKTIEQLSETCRQFLLQLIEHCQNKSETEKTISD FDDQELTEDALQEIADMLSFH*" /label="ppsD CDS" gene complement(1794650..1805461) /gene="ppsD" /locus_tag="BSU_18310" /old_locus_tag="BSU18310" /label="ppsD gene" promotor_-35 1797670..1797673 /Source="Nicolas_upshift_promotors" /id="U1480" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.696303696303696" /psig="0.87012987012987" /xcortree=1814 /SigmaFactorBS="cgtaacagcctccggctttccacacaccaagtatggatgCTA TcatactgaacgaacgaTGCATCATGATGCCTACTGGtgtgtccggcttaacacctcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1797690..1797709 /Source="Nicolas_upshift_promotors" /id="U1480" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.696303696303696" /psig="0.87012987012987" /xcortree=1814 /SigmaFactorBS="cgtaacagcctccggctttccacacaccaagtatggatgCTA TcatactgaacgaacgaTGCATCATGATGCCTACTGGtgtgtccggcttaacacctcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1797691 /Source="Nicolas_upshifts" /id="U1480" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.696303696303696" /psig="0.87012987012987" /xcortree=1814 /SigmaFactorBS="cgtaacagcctccggctttccacacaccaagtatggatgCTA TcatactgaacgaacgaTGCATCATGATGCCTACTGGtgtgtccggcttaacacctcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1805486..1813153) /gene="ppsC" /locus_tag="BSU_18320" /old_locus_tag="BSU18320" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9889147, 10471562, 16707694, 26284661, 28477175" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9889147, 10471562, 16707694, 26284661, 28477175; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="non-ribosomal plipastatin synthetase C involved in synthesis of plipastatin" /protein_id="NP_389714.1" /db_xref="EnsemblGenomes-Gn:BSU18320" /db_xref="EnsemblGenomes-Tr:CAB13715" /db_xref="GOA:P39847" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR001242" /db_xref="InterPro:IPR006162" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR010060" /db_xref="InterPro:IPR010071" /db_xref="InterPro:IPR020806" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="InterPro:IPR036736" /db_xref="SubtiList:BG10972" /db_xref="UniProtKB/Swiss-Prot:P39847" /translation="MPQQPEIQDIYPLSFMQEGMLFHSLYDEQSRAYFEQASFTIHGQ LDLERFQKSMDAVFDRYDIFRTAFIYKNVAKPRQVVLKQRHCPIHIEDISHLNERDKE HCTEAFKEQDKSKGFDLQTDVLMRISILKWAPDHYVCIWSHHHILMDGWCLGIVIKDF LHIYQALGKGQLPDLPPVQPYGTYIKWLMQQDREEAAEYWKKRLQHFEKSTPLPKRTD QIPNGTLQQITFAIPEKETAELQKIAAASGATLNTVFQALWGIMLQKVNRSSDAVFGS VISGRPSELKDVENMVGLFINTIPIRAQSDSLSFSDLVRRMQKDMNEAEAYSYFPLYD IQAQSALKQELIDHIIVFENTPTQQEIEELNQAGSFDFSVKDFEMEEVTNYSCSVKVI PGRTLYVRIHFQTSAYQPSMMSEIKDYLLHMVSDVISDPSLPVSKMTLLDEDKTRKIV SQNNRTVSVSPEAPTLHGLFERQAAVTPERLAIRFSGGSLTYAELDMYASRLAAHLAA RGVTNESIVGVLSERSPDMLIAVLAVLKAGGAYLPLDPAYPKERLSYMLKDSGASLLL TQPGCSAPNFSGETLEVDMTSLECEEVKRHVSASVSDGSLAYVIYTSGSTGQPKGVAV EHRQAVSFLTGMQHQFRLSEDDIVMVKTSFSFDASVWQLFWWALSGASAYLLPPGWEK DSALIVQAIHQENVTTAHFIPAMLNSFLDQAEIERLSDRTSLKRVFAGGEPLAPRTAA RFASVLPQVSLIHGYGPTEATVDAAFYVLDPERDRDRLRIPIGKPVPGARLYVLDPHL AVQPSGVAGELYIAGAGVARGYLNRPALTEERFLEDPFYLGERMYKTGDVARWLPDGN VEFLGRTDDQVKIRGYRIEPGEIEAALRSIEGVREAAVTVRTDSGEPELCAYVEGLQR NEVRAQLQRLLPGYMVPAYMIEMEQWPVTPSGKLDRNALPAPGGAADAETYTAPRNVT EMKLSQLWEDVLKNGPVGIHDNFFDRGGHSLKATALVSRIAKEFDVQVPLKDVFAHPT VEGLATVIREGTDSPYEAIKPAEKQETYPVSSAQKRIYVLQQLEDGGTGYNMPAVLEL EGKLNLERMDRAFKELIKRHESLRTAFEQDAGGDPVQRIHDEVPFTLQTTVLGARTEE EAAAAFIKPFDLSQAPLFRAQIVKVSDERHLLLVDMHHIISDGVSVNILIREFGELYN NRKLPALRIQYKDYAVWQEGFKTGDAYKTQGAYWLKQLEGELPVLDLPADHARPPMRS FAGDKVSFTLDQEVTSGLYKLARENGSTLYMVLLAAYTAFLSRLSGQEDIIVGSPIAG RPHKDLEPILGMFVNTLALRTRPEGGKPFVQYLQEVRETAMEAFEHQDYPFEELVDKL ELTRDMSRNPLFDVMFVLQNMDQESLELDELCLKPAANNGHQTSKFDLTLYAQEQPRG LLTFQMEFSTDLYKKKTIEKWLQYFNNMLLSIIKDNKAALGTINILNEDEAHYLIHEL NRTKIDYPRNETISRLFEMQAEQTPNAVAIVSDTQVFTYEDLNSWANQIASVLQIKGV GPDSVVALLTGRTPELIAGMLGILKAGGAYLPIDSNLPVERIAYMLSDSRAALLLQSE KTEKRLLGIECEQIIIEDIQKQGEAKNVESSAGPHSLAYIIYTSGSTGKPKGVMIEQR SVIRLVKNSNYITFTPEDRLLMTSSIGFDVGSFEIFGPLLNGAALHLSDQQTFLDSHQ LKRYIEHQGITTIWLTSSLFNHLTEQNEQTFSQLKHLIIGGEALSPSHVNRIRNVCPE VSIWNGYGPTENTTFSTCLHIQKTYELSIPIGRPVGNSTAFILNQWGVLQPVGAVGEL CVGGDGVARGYLGRPDLTKEKFVPHPFAPGDRLYRTGDLARWLSDGTIEYVGRIDDQV KVRGYRVELGEIETALRQIDGVKEAAVLARTAQTGSKELFGYISVKAGTNAEQVRSLL ARSLPNYMIPAYIIEMETLPLTSNGKLNRKALPEPDVASKQTYIPPRNELEEQLALIW QEVLGIQRIGIEDSFFELGGDSIKALQVSARLGRYGLSLQVSDLFRHPKIKDLSPFIR KSERIIEQGPIQGDVPWTPVQQWFFSQDIEERHHFNQSVMLFHSGRLSENALRPALKK LAEHHDALRMVYRNDDRRWIQINQGIHESQLYSLRISDLSQSESGWETKIKQEVADLQ QSINLQEGPLLHAALFKTLTGDYLFLAIHHLVVDGVSWRILLEDLSAGYQQAAAGQTI QLPPKTDSYQEYARRIQEYAQSSKLIREEAYWRSVEEQQAAELPYEIPHHVNIDFSKR DSLSFSLTEADTAVLLQNVNHAYGTDTQDILLTAASLAICEWTGGSKLRIAMEGHGRE HILPELDISRTVGWFTSMYPALISFENHRDELGTSVKTVKDTLGRIPNKGVGYGMLKY LTHPENKSITFSKTPEISFNYLGQFNDIERQDTFRPSSLGSGKDITHTWKREQIIEMS AMAADKKLHFNLSYPPARFHRNTMEQLINRIEHFLLDIMKHCAGQQKAEKTLSDFSSQ SLTAEDLDSISSLVEEL*" /label="ppsC CDS" gene complement(1805486..1813153) /gene="ppsC" /locus_tag="BSU_18320" /old_locus_tag="BSU18320" /label="ppsC gene" CDS complement(1813170..1820852) /gene="ppsB" /locus_tag="BSU_18330" /old_locus_tag="BSU18330" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9889147, 10471562, 16707694, 26284661, 28477175" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9889147, 10471562, 16707694, 26284661, 28477175; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nonribosomal plipastatin synthetase B involved in synthesis of plipastatin" /protein_id="NP_389715.1" /db_xref="EnsemblGenomes-Gn:BSU18330" /db_xref="EnsemblGenomes-Tr:CAB13716" /db_xref="GOA:P39846" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR001242" /db_xref="InterPro:IPR006162" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR010060" /db_xref="InterPro:IPR010071" /db_xref="InterPro:IPR020806" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="InterPro:IPR036736" /db_xref="SubtiList:BG10971" /db_xref="UniProtKB/Swiss-Prot:P39846" /translation="MAQSAQIQDIYPLSHMQEGMLFHSLMDFSSKAYIEQTSFTITGN LCVDSFQKSLNLLVSRYDIFRTIFIKEVPDLTGPQQVVLSNRELTVYREDISRLADQE QQTLIDAFMTKDREKGFDLQKDPLMRLALFDRGDSQYTCVWTHHHIIMDGWCLGIILK EFFSMYDSLKNNSPVQLGSTVPYSRYIEWLGEQDQEETAAYWSEYLKEYGNTASIPRI KRRTADGNYKADQVSFSLAPDMVEKLTEAAQNWGVTLNTLFMSIWGVLLHRYNAADDA VFGSVISGRPSAIDGIESMVGLFINTVPVRIRSAEGITFSSLVKAVQEDILSSEQHGY YPLYEIQNHSPLKQGLIDHIFVFENYPVQLHQALSVESENDEGALKLSDISMSEQTNY DFNIVIVPGESFYIKFSYNADVYEREEMLRIQGHLKQALDCILTNPDVAVSDINIVPP EEQQVIQLFNETERPYVNKTIPQLFEEQAHKTPEAAALKMGNECWTYRQLQVRANQIA HALIEKGVGSGDIVAVMMGRSMEMPAALLGIWKAGGAYMPLDPHFPAERLSFLLKDSQ AAQLLIEEDLISLIPPSYEGNTITIEHTESYQTEAPNMPPGDLAYLIYTSGTTGRPKG VLVDHHGIANTLQWRREEYSMTEQDISLHLFSYVFDGCVTSLFTPLLSGACVLLTTDD EAKDVLALKRKIARYKVSHMIIVPSLYRVLLEVMTADDAKSLRIVTFAGEAVTPDLLE LNQIICPSAELANEYGPTENSVATTILRHLNKKERITIGHPIRNTKVFVLHGNQMQPI GAAGELCISGAGLARGYYKQQELTQKAFSDHPFLEGERLYRTGDAGRFLPDGTIEYIG RFDDQVKIRGYRIELREIETVLRQAPGVKEAAVLARDVSAEEKELVAYIVPEKGNSLP DLYQHLAGTLPSYMIPASIINISQMPLTSSGKLDRFALPEPENNTSVTYMAPRTLIEA DLAHIWEDVLNKQHIGIRDDFFQLGGQSLKAAALVSRIHKKLNVELPLSEVFSYPTVE SMAVKLMSLKEHAFTQIEPADQRDVYPLSFSQKRLYALHQLADDSTGYNMPAVLELRG NLNRQRLRSVLTELVNRHEALRTVFVLDRDEPVQIIYPEMAFDLKELEMESEQMLESA IETFIKPFYLSSGPLFRACVITMGNNRGFLLLDMHHIIADGVSMSTLVQEFTDLYCGK ELPALNLHYKDFAVWQQEKHPKELYKKQEAYWLGQLGGSLPTLELPLDKTRPRLPDFR GGTIEVNIDKDMADELHRLMAETGTTLYMILLAVYSILLSKLSGQEDIVVGSPAAGRP HADLERVIGMFVNTLAMRSKPEGHKTFSSYLHDIRHLALTAYEHQDYPFEELADKLDT NREVNRNPLFDAMLVLQSSEDFRFEVPGLSISSVTPKHDISKFDLTLHAEEHLSGIRC RFEYSTALFEEETITQWASYFIELVKGVTADTEMRISNMQLLPAAERRLLLEKMGQYA AYPRNENIVSLFEKQVAQYPEHIAVVCGHSQLTYRDLNEKAERAAAMLIKQGVRTGDI VGLMLDRSPDMIIGVLSILKAGGAYLPIDPEYPKERISFMLNDSGAKLLLTERGLNKP ADYTGHILYIDECENNSIPADVNIEEIVTDQPAYVIYTSGTTGQPKGVIVEHRNVISL LKHQNLPFEFNHEDVWTLFHSYCFDFSVWEMFGALLNGSTLVVVSKETARDPQAFRLL LKKERVTVLNQTPTAFYGLMLEDQNHTDHLNIRYVIFGGEALQPGLLQSWNEKYPHTD LINMYGITETTVHVTFKKLSAADIAKNKSNIGRPLSTLQAHVMDAHMNLQPTGVPGEL YIGGEGVARGYLNRDELTADRFVSNPYLPGDRLYRTGDLAKRLSNGELEYLGRIDEQV KVRGHRIELGEIQAALLQYPMIKEAAVITRADEQGQTAIYAYMVIKDQQAANISDIRT YLKNALPDFMLPARMIQIDSIPVTVNGKLDQKALPEPEKQAYTADDISPRNEIETVMA EIWEELLNVDELGVSANFFKLGGDSIKALQVCARLKQRGFETTVREMFEHQTLGELSA RVRKDVRAIDQGPVEGEITWTPIQQWFFSQSLESHHFNQSVMIYRAERFDEAALRKVL KSLVTHHDALRIVCRHEDGRQVQINRGIDLSDEELYALELFDVKDSLTEARNTIEEAA SRMQEHIRLETGPLLHAGLFRTENGDHLFLTIHHLVVDAVSWRILFEDFSTAYKQAVS GESIKLPQKTDSYLTYSQRIADYSISRQVQREAAYWDECENRHIQPIPKDNDAASNTF KDTEVIDFELSRHHTELLLTAAHKAYSTEMNDILLTALGLALQKWTGNNQFKISMEGH GRESYLEDIDISRTVGWFTSIYPVWLDMRDSDHKDKEERLGHLIKQTKDMLHRIPHKG AGYGVLKYISKRWGSQKNSPEISFNYLGQFDQDIQSNAFEVSDIKPGNEISPNWERPY ALDISGAVSSGCLNMHIIYNRFQFEEKTIQTFSRHFKQTLENIIEHCTGKENQEWSAS DFTDEDLTLDELSEIMGAVNKL*" /label="ppsB CDS" gene complement(1813170..1820852) /gene="ppsB" /locus_tag="BSU_18330" /old_locus_tag="BSU18330" /label="ppsB gene" downshifts complement(1816841) /Source="Nicolas_upshifts" /id="D1002" /incds=1 /nref=2 /ntot=18 /MaxReadThrough="4.83331" /MaxDrop="4.93461" /score="20.5621533" /energy="-10.2" /TU="U1481,U1483" /idTUdmin="U1481" /TUdmin="-5742" /isTUend="FALSE" /label="downshifts" upshifts complement(1816885) /Source="Nicolas_upshifts" /id="U1481" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.962037962037962" /psig="0.000999000999001" /xcortree=13 /SigmaFactorBS="agctaagcgggcaagaggatattgttgtcggttCGCCtgctg ccggaagaccgcACGCTgatctggagcgcgtcatcggaatgttcgtcaatacattggc g" /listShort="ppsC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1816887..1816891) /Source="Nicolas_upshift_promotors" /id="U1481" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.962037962037962" /psig="0.000999000999001" /xcortree=13 /SigmaFactorBS="agctaagcgggcaagaggatattgttgtcggttCGCCtgctg ccggaagaccgcACGCTgatctggagcgcgtcatcggaatgttcgtcaatacattggc g" /listShort="ppsC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1816909..1816912) /Source="Nicolas_upshift_promotors" /id="U1481" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.962037962037962" /psig="0.000999000999001" /xcortree=13 /SigmaFactorBS="agctaagcgggcaagaggatattgttgtcggttCGCCtgctg ccggaagaccgcACGCTgatctggagcgcgtcatcggaatgttcgtcaatacattggc g" /listShort="ppsC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1817188..1817192 /Source="Nicolas_upshift_promotors" /id="U1482" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.547452547452547" /psig="0.993006993006993" /xcortree=1818 /SigmaFactorBS="ccagtaggcctcctgttttttgtatagctctttcgggtgctt cTCTTGctgccaaacagcaaaATCCTTATAATGCAGGTTTAaagctggcaactctttt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1817205 /Source="Nicolas_upshifts" /id="U1482" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.547452547452547" /psig="0.993006993006993" /xcortree=1818 /SigmaFactorBS="ccagtaggcctcctgttttttgtatagctctttcgggtgctt cTCTTGctgccaaacagcaaaATCCTTATAATGCAGGTTTAaagctggcaactctttt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1817208..1817227 /Source="Nicolas_upshift_promotors" /id="U1482" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.547452547452547" /psig="0.993006993006993" /xcortree=1818 /SigmaFactorBS="ccagtaggcctcctgttttttgtatagctctttcgggtgctt cTCTTGctgccaaacagcaaaATCCTTATAATGCAGGTTTAaagctggcaactctttt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(1820877..1828562) /gene="ppsA" /locus_tag="BSU_18340" /old_locus_tag="BSU18340" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9889147, 10471562, 14762003, 16707694, 26284661, 26268540" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9889147, 10471562, 14762003, 16707694, 26284661, 26268540; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="non-ribosomal plipastatin synthetase A involved in synthesis of plipastatin" /protein_id="NP_389716.2" /db_xref="EnsemblGenomes-Gn:BSU18340" /db_xref="EnsemblGenomes-Tr:CAB13717" /db_xref="GOA:P39845" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR001242" /db_xref="InterPro:IPR006162" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR010060" /db_xref="InterPro:IPR010071" /db_xref="InterPro:IPR020806" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="InterPro:IPR036736" /db_xref="SubtiList:BG10970" /db_xref="UniProtKB/Swiss-Prot:P39845" /translation="MSEHTYSLTHAQRRVWFTELLEPDTSICNLTACVKFKGNIELDT LEGALNHSISRNDAIRFQLLEGEELEPRLHLTEYKYYPLRIIDFSNVEMIEIEQWIQD QASIPFKLFNSPLFQFYLLRIDSHEVWLFAKFHHIIMDGISLNVMGNQIIDLYQKMKK KDPLPDQPEPSYLSYIEKESQYLQSPRFAKDRLFWTQTFEHPLEYHSLADQTSLQKQS TSASRDTIILSPDLEQTIRIFCEEHKINIISLFMASFYICISRITSKKDLAIGTYYGN RGSKAEKEMLGMFVSSLPIRITVDPDTDFLSFVRTIGREQLSVMRHQRFPYNLLVNEL RNEQKDLHNLIGISMQYQPLQWHNADDFDYETALYFSGYTANELSVQIQERIDNGTIQ LNFDYQNTLFSLEDIKRIQSHLLTILENALKHPHSFIRELDMTNTREKQKLLYEFNKT EAVSPKAFTLHGLFERQAAFTPERLAIRFSGGSLTYAELDMYASRLAAHLAARGVTNE SIVGVLSERSPDMLIAVLAVLKAGGAYLPLDPAYPKERLSYMLKDSGASLLLTQPGCS APNFSGETLEVDMTSLASEKAENHEFTPADGGSLAYVIYTSGSTGQPKGVAVEHRQAV SFLTGMQHQFPLSEDDIVMVKTSFSFDASVWQLFWWSLSGASAYLLPPGWEKDSALIV QAIHQENVTTAHFIPAMLNSFLDQAEIERLSDRTSLKRVFAGGEPLAPRTAARFASVL PQVSLIHGYGPTEATVDAAFYVLDPERDRDRLRIPIGKPVPGARLYVLDPHLAVQPSG VAGELYIAGAGVARGYLNRPALTEERFLEDPFYPGERMYKTGDVARWLPDGNVEFLGR TDDQVKIRGYRIEPGEIEAALRSIEGVREAAVTVRTDSGEPELCAYVEGLQRNEVRAQ LERLLPGYMVPAYMIEMEQWPVTPSGKLDRNALPAPGGAADAETYTAPRNVTEMKLSQ LWEDVLKNGPVGIHDNFFDRGGHSLKATALVSRIAKEFDVQVPLKDVFAHPTVEGLAT VIREGTDSPYEAIKPAEKQETYPVSSAQKRIYVLQQLEDGGTGYNMPAVLELEGKLNP ERMERAFKELIKRHESLRTSFEQDAGGDPVQRIHDEVPFTLQTTVLGERTEQEAAAAF IKPFDLSQAPLFRAQIVKISDERHLLLVDMHHIISDGVSVNILIREFGELYNNRNLPA LRIQYKDYAVWREGFKTGDAYKTQEAYWLKQLEGELPVLDLPADHARPPVRSFAGDKV SFTLDQEVASGLHKLARENGSTLYMVLLAAYTAFLSRLSGQEDIIVGSPIAGRPHKDL EPILGMFVNTLALRTRPEGGKPFVQYLQEVRETALEAFEHQDYPFEELVDKLELTRDM SRNPVFDAMFILQNVEKQDIDLREIKVRPANFAHHISLFDITLIATEISGSICCEMEF STEVFLKATIERWADHFIEFLHEALSTPETSLAQINILSDKEKQKIVFEFNKTQVEFA QKDIPFHRIFEAKAEENPEHIAVIDNETEISYRLLNERANRLARTLQNRKGPKPTVAV LAKRSIDAIVGVLAVMKAGGVYIPIDAHYPKARIEYILRDSGADILLLQRELKHLISN SPESEMSHIFLDDEGSFEESNCNLNLSPAPEEPVYIIYTSGTTGAPKGVIVTYQNFTH AALAWRQIYELDRKPVRLLQIASFSFDVFSGDLARTLTNGGTLIVCPDETRLEPAEIY KIIKSQRITVMESTPALIIPVMEYVYRNQFKLPDLDILILGSDMVKAQDFKTLTDRFG QSMRIINSYGVTEATIDSSFYETSMGGECTGDNVPIGSPLPNVHMYVLSQTDQIQPIG VAGELCIGGAGVAKGYHHKPDLTQMKFTENPFVSGERLYRTGDRACWLPNGTIRLLGR MDYQVKINGYRIETEEIESVLLQTGLVREAAVAVQHDKNGQAGLAAYIVPSDVNTNAL RAALTKELPAYMIPAYLIPLVNMPLTLNGKLDRNALPAPNNVLSRPYTAPVNDLQKTM AYIWEDVLSMSRVGIHDSFFELGGDSIKALQVAARLAAEGWSMTIRDLFRYSTIQELC GHITPLASQADQGPAEGEAELTPIQRRFFGQVHAFHYHYNQSVMLFSEKGFNANALHL ALRKITEHHDAIRMIFQRDQNGHVIQFNRGINHKDHELFGLYISDWTKASLERAHLDE KLAAEETVIQSKMNVEKGPLLQAGLFKTAEGDHLLIALHHLVIDGVSWRILLEDLAAA YQQALEKKEIQLPPKTDSYLSYADGLTQIAESKQLLSEKTYWQTILDAHTAFLPKDIE NVPDKLQMNSDAAAFVLSGDWTEKLLFETQQAYGTDANELLLTALGMALSEWTGHDQI VISTEGHGREGHVPNIDISRTVGWFTSIYPILLDMGIPEPFEDQLAYRIKTTKDMLRR VPNKGTGYGLLTHIGELRHKEPEVSFNYLGQFSEEKEVETFQLSYYQPRYEIAGERER EYELDINALITDGRLHVKAVYTQVFSKHSIECFMDRFHRHLIETIEHCSQKKAREKTL SDFSNKELTLSALSSIEDLVKDL*" /label="ppsA CDS" gene complement(1820877..1828562) /gene="ppsA" /locus_tag="BSU_18340" /old_locus_tag="BSU18340" /label="ppsA gene" S_feature complement(1828563..1828671) /Source="Nicolas_S_feature" /locus_tag="new_1997958_1998066_c" /HighExp="T1.30H, T1.0H, T0.30H, S1, M0t90, T2.30H, LPhT, C90, LoTm, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.982" /TUlongSig="NA" /TUlongPSig="NA" /label="S679" promotor_-10 complement(1828656..1828675) /Source="Nicolas_upshift_promotors" /id="U1483" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.428571428571429" /psig="0.982017982017982" /xcortree=557 /SigmaFactorBS="attcaaaaaaaatgttataaaaatttaatgtttttTATTGTA CtttaaaaaatatcCGTTAATATAGTGCATATATggattatatagtcatataatttct t" /listShort="S679, ppsA, ppsB, ppsC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1828671) /Source="Nicolas_upshifts" /id="U1483" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.428571428571429" /psig="0.982017982017982" /xcortree=557 /SigmaFactorBS="attcaaaaaaaatgttataaaaatttaatgtttttTATTGTA CtttaaaaaatatcCGTTAATATAGTGCATATATggattatatagtcatataatttct t" /listShort="S679, ppsA, ppsB, ppsC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1828689..1828696) /Source="Nicolas_upshift_promotors" /id="U1483" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.428571428571429" /psig="0.982017982017982" /xcortree=557 /SigmaFactorBS="attcaaaaaaaatgttataaaaatttaatgtttttTATTGTA CtttaaaaaatatcCGTTAATATAGTGCATATATggattatatagtcatataatttct t" /listShort="S679, ppsA, ppsB, ppsC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1828945..1830420) /gene="dacC" /locus_tag="BSU_18350" /old_locus_tag="BSU18350" /EC_number="3.4.16.4" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:9733705, 9864321, 11160090, 14731276, 17582436, 19758330" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9733705, 9864321, 11160090, 14731276, 17582436, 19758330; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="D-alanyl-D-alanine carboxypeptidase" /protein_id="NP_389717.1" /db_xref="EnsemblGenomes-Gn:BSU18350" /db_xref="EnsemblGenomes-Tr:CAB13718" /db_xref="GOA:P39844" /db_xref="InterPro:IPR000667" /db_xref="InterPro:IPR012338" /db_xref="PDB:1W5D" /db_xref="PDB:2J9P" /db_xref="SubtiList:BG10969" /db_xref="UniProtKB/Swiss-Prot:P39844" /translation="MKKSIKLYVAVLLLFVVASVPYMHQAALAAEKQDALSGQIDKIL ADHPALEGAMAGITVRSAETGAVLYEHSGDTRMRPASSLKLLTAAAALSVLGENYSFT TEVRTDGTLKGKKLNGNLYLKGKGDPTLLPSDFDKMAEILKHSGVKVIKGNLIGDDTW HDDMRLSPDMPWSDEYTYYGAPISALTASPNEDYDAGTVIVEVTPNQKEGEEPAVSVS PKTDYITIKNDAKTTAAGSEKDLTIEREHGTNTITIEGSVPVDANKTKEWISVWEPAG YALDLFKQSLKKQGITVKGDIKTGEAPSSSDVLLSHRSMPLSKLFVPFMKLSNNGHAE VLVKEMGKVKKGEGSWEKGLEVLNSTLPEFGVDSKSLVLRDGSGISHIDAVSSDQLSQ LLYDIQDQSWFSAYLNSLPVAGNPDRMVGGTLRNRMKGTPAQGKVRAKTGSLSTVSSL SGYAETKSGKKLVFSILLNGLIDEEDGKDIEDQIAVILANQ*" /label="dacC CDS" gene complement(1828945..1830420) /gene="dacC" /locus_tag="BSU_18350" /old_locus_tag="BSU18350" /label="dacC gene" downshifts complement(1828957) /Source="Nicolas_upshifts" /id="D1003" /incds=0 /nref=126 /ntot=224 /MaxReadThrough="1.56173" /MaxDrop="5.81468" /score="20.5621533" /energy="-10.2" /TU="NA" /idTUdmin="U1484" /TUdmin="-16" /isTUend="TRUE" /label="downshifts" CDS complement(1830454..1831431) /gene="galM" /locus_tag="BSU_18360" /old_locus_tag="BSU18360" /EC_number="5.1.3.3" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9733705, 12753898, 19758330" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9733705, 12753898, 19758330; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aldose 1-epimerase" /protein_id="NP_389718.1" /db_xref="EnsemblGenomes-Gn:BSU18360" /db_xref="EnsemblGenomes-Tr:CAB13719" /db_xref="GOA:P39840" /db_xref="InterPro:IPR008183" /db_xref="InterPro:IPR011013" /db_xref="InterPro:IPR014718" /db_xref="PDB:3MWX" /db_xref="PDB:4BZE" /db_xref="PDB:4BZF" /db_xref="PDB:4BZG" /db_xref="PDB:4BZH" /db_xref="SubtiList:BG10253" /db_xref="UniProtKB/Swiss-Prot:P39840" /translation="MANFIEKITYLGTPAIKAGNEHLEMIVVPEWGSNVISLVDKTTN VQLLREPETAESFHDTPTLYGIPILFPPNRISDGTFSFRGRTYHFDINEKDKHNHLHG FLYHEKWNVVTTKQTDEGVIVETEIDLSELPHVQKQFPHHAVVRMTYTIKENTLFKHA TVMNKGKEAFPWGIGYHTTFIFPAESSLFSLTADQQWELDERLLPTGKLMDVPYKEAL HEGMDLRHKQLDDVFLSSYQKRGGENQAVIYHQHAHISIIYKADEQFKHWVVYNADGK QGYLCPEPYTWVTNAVNLDLPSSLTGLQVLEPGEETTAKSSITIELNHQ*" /label="galM CDS" gene complement(1830454..1831431) /gene="galM" /locus_tag="BSU_18360" /old_locus_tag="BSU18360" /label="galM gene" promotor_-10 complement(1831460..1831478) /Source="Nicolas_upshift_promotors" /id="U1484" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=537 /SigmaFactorBS="gtgtttttttatttgataggggaaaatataaaatGGAGGAAA TatggtacagtaCATTGAATTCTTATACTAGcaatgaatcaaggagaggttgagtaaa c" /listShort="yoxA, dacC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1831472) /Source="Nicolas_upshifts" /id="U1484" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=537 /SigmaFactorBS="gtgtttttttatttgataggggaaaatataaaatGGAGGAAA TatggtacagtaCATTGAATTCTTATACTAGcaatgaatcaaggagaggttgagtaaa c" /listShort="yoxA, dacC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1831490..1831498) /Source="Nicolas_upshift_promotors" /id="U1484" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=537 /SigmaFactorBS="gtgtttttttatttgataggggaaaatataaaatGGAGGAAA TatggtacagtaCATTGAATTCTTATACTAGcaatgaatcaaggagaggttgagtaaa c" /listShort="yoxA, dacC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1831565..1832956) /gene="yoeA" /locus_tag="BSU_18370" /old_locus_tag="BSU18370" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 28472044; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative Na+-driven efflux transporter" /protein_id="NP_389719.2" /db_xref="EnsemblGenomes-Gn:BSU18370" /db_xref="EnsemblGenomes-Tr:CAB13720" /db_xref="GOA:O34474" /db_xref="InterPro:IPR002528" /db_xref="SubtiList:BG13548" /db_xref="UniProtKB/Swiss-Prot:O34474" /translation="METSQEPLVTQKKSKPSVWRSMSLFLVPLLLSNVLQSVGQLVGM MAVGRWLGVDAVAAVSSFFPLFFLLISFTIGIGSGSSILIGQAYGAKNEERLKAVVGT TLTFTFLLGVVLAVIGSIFTLDILRLMGTPENVIHVSANYARILFYAMPFMFLYFAYT TFLRGTGDSKTPFYTLIVSTVINIALLPVLILGMFGFPKLGIYGSAYATVISTIATFL VLMVYLRKRKHPLQFDKTVRRYLKMDKELLVLLLRLGVPASINMILVSLSEIAVISFV NHYGSNATAAYGVVNQVASYVQMPAVSLGIAVSIFAAQSIGANEFDRLKQVIRVGIWL NYIIGGVLIILIYVFSHQILSLFLTEQETLYIAHRLLMITLWSYLLFGNAQIISATMR ASGTVLWPTVISIFAIWGVEVPVAFVLSHYTKLEILGVWVGYPAAFAVSLLLIYGYYQ FVWKKKQITRLIQ*" /label="yoeA CDS" gene complement(1831565..1832956) /gene="yoeA" /locus_tag="BSU_18370" /old_locus_tag="BSU18370" /label="yoeA gene" downshifts complement(1831579) /Source="Nicolas_upshifts" /id="D1004" /incds=0 /nref=74 /ntot=213 /MaxReadThrough="2.12119" /MaxDrop="5.14152" /score="31.8413544" /energy="-12.3" /TU="NA" /idTUdmin="U1486" /TUdmin=2 /isTUend="TRUE" /label="downshifts" downshifts 1831725 /Source="Nicolas_upshifts" /id="D1005" /incds=1 /nref=1 /ntot=3 /MaxReadThrough="1.76262" /MaxDrop="3.63403" /score="24.8192541" /energy="-9.3" /TU="NA" /idTUdmin="U1485" /TUdmin="-1452" /isTUend="FALSE" /label="downshifts" promotor_-35 1832746..1832752 /Source="Nicolas_upshift_promotors" /id="U1485" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=200 /SigmaFactorBS="acttcctgaaccgatcccaatcgtaaatgAGATTAAaagaaa aaataacGGGAAAAAGGATGATACAGctgccactgcatcaacaccgagccatctgcct a" /listShort="S680" /listLong="iseA" /label="promotor_-35" promotor_-10 1832766..1832784 /Source="Nicolas_upshift_promotors" /id="U1485" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=200 /SigmaFactorBS="acttcctgaaccgatcccaatcgtaaatgAGATTAAaagaaa aaataacGGGAAAAAGGATGATACAGctgccactgcatcaacaccgagccatctgcct a" /listShort="S680" /listLong="iseA" /label="promotor_-10" S_feature 1832777..1833110 /Source="Nicolas_S_feature" /locus_tag="new_2002172_2002505" /HighExp="M9-stat, Etha, Gly, S8, Sw, S7, B60, S6, Salt, C30" /AntisenseName="yoeA" /AntisenseCor="9.0133358617756607E-2" /AntisenseRegPval="-0.9" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S680" upshifts 1832777 /Source="Nicolas_upshifts" /id="U1485" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=200 /SigmaFactorBS="acttcctgaaccgatcccaatcgtaaatgAGATTAAaagaaa aaataacGGGAAAAAGGATGATACAGctgccactgcatcaacaccgagccatctgcct a" /listShort="S680" /listLong="iseA" /label="upshifts" S_feature complement(1832957..1833061) /Source="Nicolas_S_feature" /locus_tag="new_2002352_2002456_c" /HighExp="S8, LBGstat, Etha, Cold, S7, T-1.40H, S2, C90, nit, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.456" /TUlongSig="NA" /TUlongPSig="NA" /label="S681" promotor_no_box complement(1833021..1833121) /Source="Nicolas_upshift_promotors" /id="U1486" /multdbtbs="-" /comp="M1" /sig="Sig-" /pcomp="0.455544455544456" /psig="0.455544455544456" /xcortree=562 /SigmaFactorBS="ttacttgctagtttattcttcataagctaaaaagatgtgtaa aattagaagaatcgggaagggtttcataagtgcagtgatgaataataacatgttacat a" /listShort="S681, yoeA" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(1833061) /Source="Nicolas_upshifts" /id="U1486" /multdbtbs="-" /comp="M1" /sig="Sig-" /pcomp="0.455544455544456" /psig="0.455544455544456" /xcortree=562 /SigmaFactorBS="ttacttgctagtttattcttcataagctaaaaagatgtgtaa aattagaagaatcgggaagggtttcataagtgcagtgatgaataataacatgttacat a" /listShort="S681, yoeA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1833083..1833088 /Source="Nicolas_upshift_promotors" /id="U1487" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1154 /SigmaFactorBS="tatgaaacccttcccgattcttctaattttaCACATCttttt agcttatgaaGAATAAACTAGCAAGTAATggcgtattttttgtgagtaaaagaataaa a" /listShort="iseA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1833104..1833122 /Source="Nicolas_upshift_promotors" /id="U1487" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1154 /SigmaFactorBS="tatgaaacccttcccgattcttctaattttaCACATCttttt agcttatgaaGAATAAACTAGCAAGTAATggcgtattttttgtgagtaaaagaataaa a" /listShort="iseA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1833112 /Source="Nicolas_upshifts" /id="U1487" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1154 /SigmaFactorBS="tatgaaacccttcccgattcttctaattttaCACATCttttt agcttatgaaGAATAAACTAGCAAGTAATggcgtattttttgtgagtaaaagaataaa a" /listShort="iseA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1833170..1833177 /Source="Nicolas_upshift_promotors" /id="U1488" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig="0.993006993006993" /xcortree=1549 /SigmaFactorBS="ttgtgagtaaaagaataaaaaataatttatgcaaaagTATTG TAAtctatccgtaatTATTGTAACATTTGTAACATaagagaaagagattttgaaggag a" /listShort="iseA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1833190..1833209 /Source="Nicolas_upshift_promotors" /id="U1488" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig="0.993006993006993" /xcortree=1549 /SigmaFactorBS="ttgtgagtaaaagaataaaaaataatttatgcaaaagTATTG TAAtctatccgtaatTATTGTAACATTTGTAACATaagagaaagagattttgaaggag a" /listShort="iseA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1833193 /Source="Nicolas_upshifts" /id="U1488" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig="0.993006993006993" /xcortree=1549 /SigmaFactorBS="ttgtgagtaaaagaataaaaaataatttatgcaaaagTATTG TAAtctatccgtaatTATTGTAACATTTGTAACATaagagaaagagattttgaaggag a" /listShort="iseA" /GFF_Attribute="listLong" /label="upshifts" CDS 1833242..1833787 /gene="iseA" /locus_tag="BSU_18380" /old_locus_tag="BSU18380" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:17483219, 17581128, 18761694, 22720735, 23091053" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17483219, 17581128, 18761694, 22720735, 23091053; Product type r: regulator" /codon_start=1 /transl_table=11 /product="inhibitor of DL-endopeptidases involved in cell-separation" /protein_id="NP_389720.2" /db_xref="EnsemblGenomes-Gn:BSU18380" /db_xref="EnsemblGenomes-Tr:CAB13721" /db_xref="InterPro:IPR031841" /db_xref="PDB:2RSX" /db_xref="SubtiList:BG13549" /db_xref="UniProtKB/Swiss-Prot:O34841" /translation="MKKCLLFLTTIALILSLSTNAFAKNTSGDLSQKQALQLALSARE HFWNTMSGHNPKVKKAVCPSGTFEYQNLQYVYMCSDLGTKAKAVNYLTPIFTKTAIEK GFKDYHFTVSKGKLAVPIGDGDNLLNWKKSTAKLISKKGSTITYEFTVPTLDGSPSAK RKVTFVKENKKWKVNQFDAVI*" /label="iseA CDS" gene 1833242..1833787 /gene="iseA" /locus_tag="BSU_18380" /old_locus_tag="BSU18380" /label="iseA gene" downshifts 1833771 /Source="Nicolas_upshifts" /id="D1006" /incds=0 /nref=164 /ntot=264 /MaxReadThrough="4.38689" /MaxDrop="8.27665" /score="24.8192541" /energy="-9.3" /TU="NA" /idTUdmin="U1487" /TUdmin=0 /isTUend="TRUE" /label="downshifts" tRNA complement(1833881..1833953) /gene="trnSL-Arg1" /locus_tag="BSU_tRNA_85" /product="tRNA-Arg" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Arg1 tRNA" gene complement(1833881..1833953) /gene="trnSL-Arg1" /locus_tag="BSU_tRNA_85" /label="trnSL-Arg1 gene" downshifts complement(1833979) /Source="Nicolas_upshifts" /id="D1007" /incds=0 /nref=4 /ntot=118 /MaxReadThrough="1.99821" /MaxDrop="3.03097" /score="3.94141467" /energy="-15.1" /TU="NA" /idTUdmin="U1489" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1834006..1834551) /gene="yoeC" /locus_tag="BSU_18390" /old_locus_tag="BSU18390" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative bacteriophage integrase" /protein_id="NP_389721.2" /db_xref="EnsemblGenomes-Gn:BSU18390" /db_xref="EnsemblGenomes-Tr:CAB13722" /db_xref="GOA:O35009" /db_xref="InterPro:IPR002104" /db_xref="InterPro:IPR011010" /db_xref="InterPro:IPR013762" /db_xref="SubtiList:BG13550" /db_xref="UniProtKB/Swiss-Prot:O35009" /translation="MHIVQPIRSLEKIQEVKQYLLNKNKRDYFLFIFGINSALRISDI LPLQVKDVQNKDHLWATESKTKKKRKILILESLKQEIYEYTKDMKENEYLFKSVRTRK PISRIQAYRILREAAAACGLEEIGTHTLRKTFGYHFYQRTKDIAELQRILNHSSPSIT MRYIGIDEDTTRAAYKVFGGL*" /label="yoeC CDS" gene complement(1834006..1834551) /gene="yoeC" /locus_tag="BSU_18390" /old_locus_tag="BSU18390" /label="yoeC gene" promotor_-10 complement(1834591..1834610) /Source="Nicolas_upshift_promotors" /id="U1489" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.642357642357642" /psig="0.999000999001" /xcortree=2388 /SigmaFactorBS="actatgtatattatgttacataaacgccgccgcaCTTTGACA ttcaacgtttttcAGCTATAATAGTAACATAGAcctcaaaatgttacataacggtttt t" /listShort="yoeC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1834605) /Source="Nicolas_upshifts" /id="U1489" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.642357642357642" /psig="0.999000999001" /xcortree=2388 /SigmaFactorBS="actatgtatattatgttacataaacgccgccgcaCTTTGACA ttcaacgtttttcAGCTATAATAGTAACATAGAcctcaaaatgttacataacggtttt t" /listShort="yoeC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1834624..1834631) /Source="Nicolas_upshift_promotors" /id="U1489" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.642357642357642" /psig="0.999000999001" /xcortree=2388 /SigmaFactorBS="actatgtatattatgttacataaacgccgccgcaCTTTGACA ttcaacgtttttcAGCTATAATAGTAACATAGAcctcaaaatgttacataacggtttt t" /listShort="yoeC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1834867..1835097) /gene="yoeD" /locus_tag="BSU_18400" /old_locus_tag="BSU18400" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16880568; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative excisionase" /protein_id="NP_389722.1" /db_xref="EnsemblGenomes-Gn:BSU18400" /db_xref="EnsemblGenomes-Tr:CAB13723" /db_xref="GOA:O34555" /db_xref="InterPro:IPR010093" /db_xref="SubtiList:BG13551" /db_xref="UniProtKB/Swiss-Prot:O34555" /translation="MYLTIEETAEYTNLSEDYIKSLVLEGKIRAVHDGEQFLIYKEQF KTHLEQLENYKALVQEILNEPIPEDIDVKDED*" /label="yoeD CDS" gene complement(1834867..1835097) /gene="yoeD" /locus_tag="BSU_18400" /old_locus_tag="BSU18400" /label="yoeD gene" downshifts complement(1834881) /Source="Nicolas_upshifts" /id="D1008" /incds=0 /nref=193 /ntot=248 /MaxReadThrough="0.81591" /MaxDrop="5.75977" /score="19.8797745" /energy="-8.6" /TU="NA" /idTUdmin="U1490" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1835123..1835142) /Source="Nicolas_upshift_promotors" /id="U1490" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.931068931068931" /psig=1 /xcortree=2156 /SigmaFactorBS="atagtgcataatgccgtttttctgtgcagaattgaTTATATT gatatgagccaTGTGCTATATTAGAATCAGCatacggattaagaagggactgctatat g" /listShort="yoeD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1835135) /Source="Nicolas_upshifts" /id="U1490" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.931068931068931" /psig=1 /xcortree=2156 /SigmaFactorBS="atagtgcataatgccgtttttctgtgcagaattgaTTATATT gatatgagccaTGTGCTATATTAGAATCAGCatacggattaagaagggactgctatat g" /listShort="yoeD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1835154..1835160) /Source="Nicolas_upshift_promotors" /id="U1490" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.931068931068931" /psig=1 /xcortree=2156 /SigmaFactorBS="atagtgcataatgccgtttttctgtgcagaattgaTTATATT gatatgagccaTGTGCTATATTAGAATCAGCatacggattaagaagggactgctatat g" /listShort="yoeD" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(1835189..1835208) /Source="Nicolas_upshift_promotors" /id="U1491" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.656343656343656" /psig="0.971028971028971" /xcortree=1438 /SigmaFactorBS="gtattgttacaatcttagcgtaaaaaaattacagcgttttca caagtgacaAATGGTATATTATATAGTGCataatgccgtttttctgtgcagaattgat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1835199) /Source="Nicolas_upshifts" /id="U1491" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.656343656343656" /psig="0.971028971028971" /xcortree=1438 /SigmaFactorBS="gtattgttacaatcttagcgtaaaaaaattacagcgttttca caagtgacaAATGGTATATTATATAGTGCataatgccgtttttctgtgcagaattgat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1835212..1835219 /Source="Nicolas_upshift_promotors" /id="U1492" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.763236763236763" /psig=1 /xcortree=470 /SigmaFactorBS="aaacggcattatgcactatataatataccatttgtCACTTGT GaaaacgctgtaatTTTTTTACGCTAAGATTGTAacaatacagcttcatataggaggg a" /listShort="ggt" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1835233..1835252 /Source="Nicolas_upshift_promotors" /id="U1492" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.763236763236763" /psig=1 /xcortree=470 /SigmaFactorBS="aaacggcattatgcactatataatataccatttgtCACTTGT GaaaacgctgtaatTTTTTTACGCTAAGATTGTAacaatacagcttcatataggaggg a" /listShort="ggt" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1835237 /Source="Nicolas_upshifts" /id="U1492" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.763236763236763" /psig=1 /xcortree=470 /SigmaFactorBS="aaacggcattatgcactatataatataccatttgtCACTTGT GaaaacgctgtaatTTTTTTACGCTAAGATTGTAacaatacagcttcatataggaggg a" /listShort="ggt" /GFF_Attribute="listLong" /label="upshifts" CDS 1835282..1837045 /gene="ggt" /locus_tag="BSU_18410" /old_locus_tag="BSU18410" /EC_number="2.3.2.2" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8763966, 23335395, 24279353, 26370226, 28120195" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8763966, 23335395, 24279353, 26370226, 28120195; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="membrane bound gamma-glutamyltranspeptidase" /protein_id="NP_389723.1" /db_xref="EnsemblGenomes-Gn:BSU18410" /db_xref="EnsemblGenomes-Tr:CAB13724" /db_xref="GOA:P54422" /db_xref="InterPro:IPR000101" /db_xref="InterPro:IPR029055" /db_xref="PDB:2V36" /db_xref="PDB:3A75" /db_xref="PDB:3WHQ" /db_xref="PDB:3WHR" /db_xref="PDB:3WHS" /db_xref="SubtiList:BG11838" /db_xref="UniProtKB/Swiss-Prot:P54422" /translation="MKRTWNVCLTALLSVLLVAGSVPFHAEAKKPPKSYDEYKQVDVG KDGMVATAHPLASEIGADVLKKGGNAIDAAVAIQFALNVTEPMMSGIGGGGFMMVYDG KTKDTTIIDSRERAPAGATPDMFLDENGKAIPFSERVTKGTAVGVPGTLKGLEEALDK WGTRSMKQLITPSIKLAEKGFPIDSVLAEAISDYQEKLSRTAAKDVFLPNGEPLKEGD TLIQKDLAKTFKLIRSKGTDAFYKGKFAKTLSDTVQDFGGSMTEKDLENYDITIDEPI WGDYQGYQIATTPPPSSGGIFLLQMLKILDHFNLSQYDVRSWEKYQLLAETMHLSYAD RASYAGDPEFVNVPLKGLLHPDYIKERQQLINLDQVNKKPKAGDPWKYQEGSANYKQV EQPKDKVEGQTTHFTVADRWGNVVSYTTTIEQLFGTGIMVPDYGVILNNELTDFDAIP GGANEVQPNKRPLSSMTPTILFKDDKPVLTVGSPGGATIISSVLQTILYHIEYGMELK AAVEEPRIYTNSMSSYRYEDGVPKDVLSKLNGMGHKFGTSPVDIGNVQSISIDHENGT FKGVADSSRNGAAIGINLKRK*" /label="ggt CDS" gene 1835282..1837045 /gene="ggt" /locus_tag="BSU_18410" /old_locus_tag="BSU18410" /label="ggt gene" downshifts 1837026 /Source="Nicolas_upshifts" /id="D1009" /incds=0 /nref=24 /ntot=49 /MaxReadThrough="1.41914" /MaxDrop="5.80171" /score="3.23845421" /energy="-10.4" /TU="NA" /idTUdmin="U1492" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1837146..1838003) /gene="ftsR" /locus_tag="BSU_18420" /old_locus_tag="BSU18420" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17526699" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17526699; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (LysR family)" /protein_id="NP_389724.1" /db_xref="EnsemblGenomes-Gn:BSU18420" /db_xref="EnsemblGenomes-Tr:CAB13725" /db_xref="GOA:O34685" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13552" /db_xref="UniProtKB/Swiss-Prot:O34685" /translation="MESGDLKIFQAVAREGSITKAAQMLNYVQSNVTARVHNLEEDLN IRLFHRTNRGMKLTAAGENLLQYADQVLSLLDQAEKSTRMSRQPKGPLRIGSLETMAV THLPEHAASFLRRFPEVDLSVNTADTHHLIQQVLDHKVDGAFVYGPVEHAAVRQLHVS HDELVLISSREGTAEDMLQQPMLFFGAGCSHRDRVKRLLEEAGIHNQKIIEFGTLEAI IKGVSAGMGTALLPKSAVDGSEHRTNVWIHQLPPSYQDLEIVFIYRKDFFITSAFQTF LDEINEMKR*" /label="ftsR CDS" gene complement(1837146..1838003) /gene="ftsR" /locus_tag="BSU_18420" /old_locus_tag="BSU18420" /label="ftsR gene" promotor_-10 complement(1838049..1838068) /Source="Nicolas_upshift_promotors" /id="U1493" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.632367632367632" /psig="0.998001998001998" /xcortree=3011 /SigmaFactorBS="ctgtctgcctcctcattaattgtattttcatatctttacaTA TTTTACatagcggttttctTCGAGTAAAATGAACAAATAtgatagccaatatcacttt t" /listShort="ftsR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1838069) /Source="Nicolas_upshifts" /id="U1493" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.632367632367632" /psig="0.998001998001998" /xcortree=3011 /SigmaFactorBS="ctgtctgcctcctcattaattgtattttcatatctttacaTA TTTTACatagcggttttctTCGAGTAAAATGAACAAATAtgatagccaatatcacttt t" /listShort="ftsR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1838082..1838089) /Source="Nicolas_upshift_promotors" /id="U1493" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.632367632367632" /psig="0.998001998001998" /xcortree=3011 /SigmaFactorBS="ctgtctgcctcctcattaattgtattttcatatctttacaTA TTTTACatagcggttttctTCGAGTAAAATGAACAAATAtgatagccaatatcacttt t" /listShort="ftsR" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1838131..1839120 /gene="yogA" /locus_tag="BSU_18430" /old_locus_tag="BSU18430" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10960106, 23873705; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_389725.1" /db_xref="EnsemblGenomes-Gn:BSU18430" /db_xref="EnsemblGenomes-Tr:CAB13726" /db_xref="GOA:O35017" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR020843" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13553" /db_xref="UniProtKB/Swiss-Prot:O35017" /translation="MKAVIHNGKAGLLGLSVQDVPSTKPGYGEVKVKLKSAGLNHRDL FLMKNKSEQDPHMILGSDGAGIIEEIGEGVKNVTVQTEVVIFPTLNWDLTENVPPVPE ILGGPSDGTLAEYVIIPSQNAIKKPAYLSWEEAGVLPLSALTAYRALFTKGQLKKGEH LLIPGIGSGVATYALFMAKAIGATVSVTSRSEEKRKKALKLGADYAFDSYSNWDEQLQ GKKIDVVLDSIGPALFSEYFRHVKPNGRIVSFGASSGDNLSFPVRSLFFPQVNVLGTS MGSGEEFQAMLAFIDKHKLRPVIDRIYPLEKACEAYKRMQEGRQFGNIGIVME*" /label="yogA CDS" gene 1838131..1839120 /gene="yogA" /locus_tag="BSU_18430" /old_locus_tag="BSU18430" /label="yogA gene" S_feature complement(1838187..1839145) /Source="Nicolas_S_feature" /locus_tag="new_2007582_2008540_c" /HighExp="T-4.40H, T-5.40H, Glu, GM 45, Glucon, GM-0.1, Gly, GM-0.2, UNK1, GM 90" /AntisenseName="yogA" /AntisenseCor="-0.49303153269799599" /AntisenseRegPval="-17.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S682" CDS complement(1839177..1840658) /gene="gltB" /locus_tag="BSU_18440" /old_locus_tag="BSU18440" /EC_number="1.4.1.13" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:3011766, 10651638, 11029411, 27223617" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3011766, 10651638, 11029411, 27223617; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamate synthase (small subunit, NADP-dependent)" /protein_id="NP_389726.2" /db_xref="EnsemblGenomes-Gn:BSU18440" /db_xref="EnsemblGenomes-Tr:CAB13727" /db_xref="GOA:O34399" /db_xref="InterPro:IPR006005" /db_xref="InterPro:IPR009051" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR028261" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG12594" /db_xref="UniProtKB/Swiss-Prot:O34399" /translation="MGKPTGFMEIKREKPAERDPLTRLKDWKEYSAPFSEEASKRQGA RCMDCGTPFCQIGADINGFTSGCPIYNLIPEWNDLVYRGRWKEALERLLKTNNFPEFT GRVCPAPCEGSCTLAISDPAVSIKNIERTIIDKGFENGWIQPRIPKKRTGKKVAIVGS GPAGLASADQLNQAGHSVTVFERADRAGGLLTYGIPNMKLEKGIVERRIKLLTQEGID FVTNTEIGVDITADELKEQFDAVILCTGAQKQRDLLIEGRDSKGVHYAMDYLTLATKS YLDSNFKDKQFIDAKGKDVIVIGGGDTGADCVATALRQKAKSVHQFGKHPKLPPARTN DNMWPEQPHVFTLEYAYEEAEAKFGRDPREYSIQTTKMVADKNGKLKELHTIQMEKVK NEHGKYEFRELPGTEKVWPAQLVFIAIGFEGTEQPLLKQFGVNSVNNKISAAYGDYQT NIDGVFAAGDARRGQSLIVWAINEGREVAREVDRYLMGSSVLP*" /label="gltB CDS" gene complement(1839177..1840658) /gene="gltB" /locus_tag="BSU_18440" /old_locus_tag="BSU18440" /label="gltB gene" downshifts complement(1839190) /Source="Nicolas_upshifts" /id="D1010" /incds=0 /nref=247 /ntot=279 /MaxReadThrough="3.292" /MaxDrop="7.52772" /score="10.4717228" /energy="-6.5" /TU="U1495" /idTUdmin="U1495" /TUdmin="-570" /isTUend="FALSE" /label="downshifts" CDS complement(1840675..1845237) /gene="gltA" /locus_tag="BSU_18450" /old_locus_tag="BSU18450" /EC_number="1.4.1.13" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:39113, 3011766, 6769440, 6774712, 7559359, 14570271, 17134717" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 39113, 3011766, 6769440, 6774712, 7559359, 14570271, 17134717; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamate synthase (large subunit, NADP-dependent)" /protein_id="NP_389727.2" /db_xref="EnsemblGenomes-Gn:BSU18450" /db_xref="EnsemblGenomes-Tr:CAB13728" /db_xref="GOA:P39812" /db_xref="InterPro:IPR002489" /db_xref="InterPro:IPR002932" /db_xref="InterPro:IPR006982" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR017932" /db_xref="InterPro:IPR029055" /db_xref="InterPro:IPR036485" /db_xref="SubtiList:BG10811" /db_xref="UniProtKB/Swiss-Prot:P39812" /translation="MTYNQMPKAQGLYRPEFEHDACGIGLYAHLKGKQTHDIVKQGLK MLCQLDHRGGQGSDPDTGDGAGLLVQIPDAFFRKECKNINLPEKERYGVGMVFFSQKE DERKKIEKQINALIEQEGQVVLGWRTVPVNVGKIGTVAQKSCPFVRQVFIGASSDLKD NLSFERKLYVIRKQAENWGVTEGLDFYFASLSSQTIVYKGLLTPEQVDAFYSDLQDEA FVSAFALVHSRFSTNTFPTWERAHPNRYLVHNGEINTLRGNINWMRAREQQFVSESFG EDLNKILPILNADGSDSSILDNAFEFFVMAGRKPAHTAMMLIPEPWTENTHMSKEKRA FYEYHSSLMEPWDGPTAISFTDGKQIGAILDRNGLRPARYYVTKDDYIIFSSEVGVIE VEQENVLYKNRLEPGKMLLIDLEEGRIISDEEVKTQIATEYPYQKWLEEELVQVNPDP ESREEEQFSDLLTRQKAFGYTYEDIQKYLIPVIKEGKDPLGSMGNDAPLAVLSDRAQS LFNYFKQLFAQVTNPPIDAIREQLVTSTMTWLGAEGDLLHPSERNVRRIKLYTPVLSN EQFYALKTIVHPDLKSQKIDVLFSEDLERGLKDMFTQAEKAISQGVSLLILSDKKMNE RLTPIPPLLAVSALHQHLIRKGLRTKVSIIVESGEAREVHHFAALIGYGADAINPYLA YATYKQEIDEGRLDISYEEAVSKYGKSITEGVVKVMSKMGISTVQSYRGAQIFEAVGI SRDVIDRYFSGTASQLGGIDLQTIAEEAQRRHREAYQDDYSKTLEPGSDFQWRNGGEH HAFNPKTIHTLQWACRRNDYNLFKQYTKAADEERIGFLRNLFAFDGNRKPLKLEEVES AESIVKRFKTGAMSFGSLSKEAHEALAIAMNRLGGKSNSGEGGEDPKRFVPDENGDDR RSAIKQIASGRFGVKSHYLVNADELQIKMAQGAKPGEGGQLPGNKVYPWVADVRGSTP GVGLISPPPHHDIYSIEDLAQLIHDLKNANRDARISVKLVSKAGVGTIAAGVAKATAD VIVISGYDGGTGASPKTSIKHTGLPWELGLAEAHQTLMLNGLRDRVVLETDGKLMTGR DVVMAALLGAEEFGFATAPLVVLGCVMMRACHLDTCPVGVATQNPELRKKFMGDPDHI VNYMLFIAEEVREYMAALGFKTFDEMIGRTDVLHASERAKEHWKASQLDLSTLLYQPE GVRTFQSPQNHKIDQSLDITTILPAVQEAIESGKEADISIEINNTNRVAGTITGSEIS KRYGEEGLPEDTIKLHFTGSAGQSFGAFVPKGMTLYLDGDSNDYVGKGLSGGKIIVKS SEGFNSASDDNVIIGNVAFYGATSGEAYINGRAGERFAVRNSGVNVVVEGIGDHGCEY MTGGSVVVLGDVGKNFAAGMSGGIAYVLTEDVKAFKRKCNLEMILFESLEDEKEIQQI KAMLERHTAYTNSQKAEDLLDQWEDSVKKFVKVIPKNYKQMLASIEEQKAAGLSDEEA IMFAFEANTKPKQNTAASGQKQAVVQ*" /label="gltA CDS" gene complement(1840675..1845237) /gene="gltA" /locus_tag="BSU_18450" /old_locus_tag="BSU18450" /label="gltA gene" promotor_no_box 1843698..1843798 /Source="Nicolas_upshift_promotors" /id="U1494" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.974025974025974" /psig="0.001998001998002" /xcortree=23 /SigmaFactorBS="taaagtagttaaacagcgattgcgctcggtcagaaagtacag caagcggagcgtcattccccattgaaccaaggggatctttgccttctttaataacagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 1843758 /Source="Nicolas_upshifts" /id="U1494" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.974025974025974" /psig="0.001998001998002" /xcortree=23 /SigmaFactorBS="taaagtagttaaacagcgattgcgctcggtcagaaagtacag caagcggagcgtcattccccattgaaccaaggggatctttgccttctttaataacagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1845238..1845309) /Source="Nicolas_S_feature" /locus_tag="new_2014633_2014704_c" /HighExp="SMM, T-5.40H, HiOs, MG 15, Glu, T-4.40H, MG 150, MG 60, UNK1, MG 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S683" promotor_-10 complement(1845289..1845308) /Source="Nicolas_upshift_promotors" /id="U1495" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.95104895104895" /psig=1 /xcortree=3025 /SigmaFactorBS="catctatctcattttgagattcttttgatctaaattataTAT TGTTTatatcgttttgaaaACCTACAATGATTATAGAGTtgttagattttatgaccgg t" /listShort="S683, gltA, gltB, S682" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 1845306..1845313 /Source="Nicolas_upshift_promotors" /id="U1496" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.727272727272727" /psig="0.966033966033966" /xcortree=2238 /SigmaFactorBS="taataccggtcataaaatctaacaactctataatcattgtaG GTTTTCAaaacgatataaacaATATATAATTTAGATCAAAAgaatctcaaaatgagat a" /listShort="gltC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(1845309) /Source="Nicolas_upshifts" /id="U1495" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.95104895104895" /psig=1 /xcortree=3025 /SigmaFactorBS="catctatctcattttgagattcttttgatctaaattataTAT TGTTTatatcgttttgaaaACCTACAATGATTATAGAGTtgttagattttatgaccgg t" /listShort="S683, gltA, gltB, S682" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1845323..1845330) /Source="Nicolas_upshift_promotors" /id="U1495" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.95104895104895" /psig=1 /xcortree=3025 /SigmaFactorBS="catctatctcattttgagattcttttgatctaaattataTAT TGTTTatatcgttttgaaaACCTACAATGATTATAGAGTtgttagattttatgaccgg t" /listShort="S683, gltA, gltB, S682" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1845325 /Source="Nicolas_upshifts" /id="U1496" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.727272727272727" /psig="0.966033966033966" /xcortree=2238 /SigmaFactorBS="taataccggtcataaaatctaacaactctataatcattgtaG GTTTTCAaaacgatataaacaATATATAATTTAGATCAAAAgaatctcaaaatgagat a" /listShort="gltC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1845328..1845347 /Source="Nicolas_upshift_promotors" /id="U1496" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.727272727272727" /psig="0.966033966033966" /xcortree=2238 /SigmaFactorBS="taataccggtcataaaatctaacaactctataatcattgtaG GTTTTCAaaacgatataaacaATATATAATTTAGATCAAAAgaatctcaaaatgagat a" /listShort="gltC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1845384..1846286 /gene="gltC" /locus_tag="BSU_18460" /old_locus_tag="BSU18460" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:2548995, 15150225, 17134717, 28294562" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2548995, 15150225, 17134717, 28294562; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (LysR family) (GltC-glutamate)" /protein_id="NP_389728.2" /db_xref="EnsemblGenomes-Gn:BSU18460" /db_xref="EnsemblGenomes-Tr:CAB13729" /db_xref="GOA:P20668" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10810" /db_xref="UniProtKB/Swiss-Prot:P20668" /translation="MELRQLRYFMEVAEREHVSEAADHLHVAQSAISRQIANLEEELN VTLFEREGRNIKLTPIGKEFLIHVKTAMKAIDYAKEQIDEYLDPHRGTVKIGFPTSLA SQLLPTVISAFKEEYPHVEFLLRQGSYKFLIEAVRNRDIDLALLGPVPTNFSDITGKI LFTEKIYALVPLNHPLAKQKTVHLIDLRNDQFVLFPEGFVLREMAIDTCKQAGFAPLV STEGEDLDAIKGLVSAGMGVTLLPESTFAETTPRFTVKIPIEFPQVKRTVGIIKPKNR ELAPSANDFYEFVIQFFSKLEQYQ*" /label="gltC CDS" gene 1845384..1846286 /gene="gltC" /locus_tag="BSU_18460" /old_locus_tag="BSU18460" /label="gltC gene" downshifts 1846266 /Source="Nicolas_upshifts" /id="D1011" /incds=0 /nref=104 /ntot=241 /MaxReadThrough="2.84467" /MaxDrop="3.98111" /score="22.3639229" /energy="-13.6" /TU="NA" /idTUdmin="U1496" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1846338..1847453) /gene="proJ" /locus_tag="BSU_18470" /old_locus_tag="BSU18470" /EC_number="2.7.2.11" /function="16.8: Protect" /function="16.14: Store" /experiment="publication(s) with functional evidences, PMID:11418582, 15804359, 21784929, 28752945" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11418582, 15804359, 21784929, 28752945; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamate 5-kinase" /protein_id="NP_389729.1" /db_xref="EnsemblGenomes-Gn:BSU18470" /db_xref="EnsemblGenomes-Tr:CAB13740" /db_xref="GOA:O07509" /db_xref="InterPro:IPR001048" /db_xref="InterPro:IPR001057" /db_xref="InterPro:IPR002478" /db_xref="InterPro:IPR005715" /db_xref="InterPro:IPR011529" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR019797" /db_xref="InterPro:IPR036393" /db_xref="InterPro:IPR036974" /db_xref="SubtiList:BG12658" /db_xref="UniProtKB/Swiss-Prot:O07509" /translation="MTPDTSMKRVVVKIGSSSLTSLHGEISIRKLEALVDQVVKLKDA GYEVILVSSGAVAAGYRKLGFIQRPEKLPEKQASASIGQGLLMEAYSKLFLAHGYVAS QILITRSDFSDEYRYNNVRNTMNVLLERGIIPIINENDTVTVNRLKFGDNDTLAAKVA GLIDADMLVILSDIDGLYDGNPRTNPEAKKIQRVSEITPDIEACAGDTGSIVGTGGMR SKLDAFKIVMASGIKGFLGQADAGDILYHAVHEQAEGTYFEAEGTLPLNQKEQWIAFN SGPEGEMILSDDCSRKITNGQSSLYLDGVQKIKGKFKSGSVVRLMDSKGTEIGLGIVN YSSVQLQEPEKKKELTNRALIDQEAFVCHVDFSLPVN*" /label="proJ CDS" gene complement(1846338..1847453) /gene="proJ" /locus_tag="BSU_18470" /old_locus_tag="BSU18470" /label="proJ gene" CDS complement(1847450..1848343) /gene="proH" /locus_tag="BSU_18480" /old_locus_tag="BSU18480" /EC_number="1.5.1.2" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11418582, 21784929, 22139509, 25344233, 28752945" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11418582, 21784929, 22139509, 25344233, 28752945; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyrroline-5-carboxylate reductase" /protein_id="NP_389730.2" /db_xref="EnsemblGenomes-Gn:BSU18480" /db_xref="EnsemblGenomes-Tr:CAB13741" /db_xref="GOA:P0CI77" /db_xref="InterPro:IPR000304" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR028939" /db_xref="InterPro:IPR029036" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11049" /db_xref="UniProtKB/Swiss-Prot:P0CI77" /translation="MRTKKRTKEMLPIFDQKKVAFIGAGSMAEGMISGIVRANKIPKQ NICVTNRSNTERLTELELQYGIKGALPNQLCIEDMDVLILAMKPKDAENALSSLKSRI QPHQLILSVLAGITTSFIEQSLLNEQPVVRVMPNTSSMIGASATAIALGKYVSEDLKK LAEALLGCMGEVYTIQENQMDIFTGIAGSGPAYFYYLMEFIEKTGEEAGLDKQLSRSI GAQTLLGAAKMLMETGEHPEILRDNITSPNGTTAAGLQALKKSGGGEAISQAIKHAAK RSKEISEDIEKTAAPLSGVIK*" /label="proH CDS" gene complement(1847450..1848343) /gene="proH" /locus_tag="BSU_18480" /old_locus_tag="BSU18480" /label="proH gene" promotor_-10 complement(1848348..1848367) /Source="Nicolas_upshift_promotors" /id="U1497" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.498501498501498" /psig="0.999000999001" /xcortree=3035 /SigmaFactorBS="gtcgaaaagaaacaatacaaatcaataatggccttcaaaCTT GACAtcatttcctcacgTGGTAACATTTTAAACGTGTgaaaatgcgaacaaaaaagcg a" /listShort="proH, proJ" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 1848356 /Source="Nicolas_upshifts" /id="D1012" /incds=0 /nref=1 /ntot=6 /MaxReadThrough="1.17009" /MaxDrop="3.27004" /score="-0.988973561" /energy="-13.3" /TU="NA" /idTUdmin="U1496" /TUdmin=2090 /isTUend="FALSE" /label="downshifts" upshifts complement(1848366) /Source="Nicolas_upshifts" /id="U1497" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.498501498501498" /psig="0.999000999001" /xcortree=3035 /SigmaFactorBS="gtcgaaaagaaacaatacaaatcaataatggccttcaaaCTT GACAtcatttcctcacgTGGTAACATTTTAAACGTGTgaaaatgcgaacaaaaaagcg a" /listShort="proH, proJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1848381..1848387) /Source="Nicolas_upshift_promotors" /id="U1497" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.498501498501498" /psig="0.999000999001" /xcortree=3035 /SigmaFactorBS="gtcgaaaagaaacaatacaaatcaataatggccttcaaaCTT GACAtcatttcctcacgTGGTAACATTTTAAACGTGTgaaaatgcgaacaaaaaagcg a" /listShort="proH, proJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1848396..1848414) /Source="Nicolas_upshift_promotors" /id="U1498" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1173 /SigmaFactorBS="gcgcagcagtgtgaaccgggtgttttctgcttttcattaTAC ATAtttgtcgaaaagaaaCAATACAAATCAATAATGGccttcaaacttgacatcattt c" /listShort="proH, proJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1848414) /Source="Nicolas_upshifts" /id="U1498" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1173 /SigmaFactorBS="gcgcagcagtgtgaaccgggtgttttctgcttttcattaTAC ATAtttgtcgaaaagaaaCAATACAAATCAATAATGGccttcaaacttgacatcattt c" /listShort="proH, proJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1848430..1848435) /Source="Nicolas_upshift_promotors" /id="U1498" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1173 /SigmaFactorBS="gcgcagcagtgtgaaccgggtgttttctgcttttcattaTAC ATAtttgtcgaaaagaaaCAATACAAATCAATAATGGccttcaaacttgacatcattt c" /listShort="proH, proJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1848491..1848859) /gene="rtp" /locus_tag="BSU_18490" /old_locus_tag="BSU18490" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:11313334, 15657033, 16822523, 17376071, 17521668, 24946150" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11313334, 15657033, 16822523, 17376071, 17521668, 24946150; Product type f : factor" /codon_start=1 /transl_table=11 /product="replication terminator protein" /protein_id="NP_389731.1" /db_xref="EnsemblGenomes-Gn:BSU18490" /db_xref="EnsemblGenomes-Tr:CAB13742" /db_xref="GOA:P0CI76" /db_xref="InterPro:IPR003432" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:1BM9" /db_xref="PDB:1F4K" /db_xref="PDB:1J0R" /db_xref="PDB:2DPD" /db_xref="PDB:2DPU" /db_xref="PDB:2DQR" /db_xref="PDB:2EFW" /db_xref="SubtiList:BG10738" /db_xref="UniProtKB/Swiss-Prot:P0CI76" /translation="MKEEKRSSTGFLVKQRAFLKLYMITMTEQERLYGLKLLEVLRSE FKEIGFKPNHTEVYRSLHELLDDGILKQIKVKKEGAKLQEVVLYQFKDYEAAKLYKKQ LKVELDRCKKLIEKALSDNF*" /label="rtp CDS" gene complement(1848491..1848859) /gene="rtp" /locus_tag="BSU_18490" /old_locus_tag="BSU18490" /label="rtp gene" promotor_-10 complement(1848894..1848912) /Source="Nicolas_upshift_promotors" /id="U1499" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=3198 /SigmaFactorBS="aatcagtaaacatgaaataactggactatcagtctttaatat aaaGAAGGAAAAcaataaaagaaAATTGAATATTTAGTACATagtgttgtcagtgaca g" /listShort="rtp" /listLong="proH" /label="promotor_-10" upshifts complement(1848917) /Source="Nicolas_upshifts" /id="U1499" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=3198 /SigmaFactorBS="aatcagtaaacatgaaataactggactatcagtctttaatat aaaGAAGGAAAAcaataaaagaaAATTGAATATTTAGTACATagtgttgtcagtgaca g" /listShort="rtp" /listLong="proH" /label="upshifts" S_feature complement(1848919..1849038) /Source="Nicolas_S_feature" /locus_tag="new_2018314_2018433_c" /HighExp="dia15, Etha, dia5, Diami, H2O2, LBGtran, LoTm, LBGexp, G180, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S684" promotor_-35 complement(1848924..1848932) /Source="Nicolas_upshift_promotors" /id="U1499" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=3198 /SigmaFactorBS="aatcagtaaacatgaaataactggactatcagtctttaatat aaaGAAGGAAAAcaataaaagaaAATTGAATATTTAGTACATagtgttgtcagtgaca g" /listShort="rtp" /listLong="proH" /label="promotor_-35" promotor_-10 complement(1849030..1849049) /Source="Nicolas_upshift_promotors" /id="U1500" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2054 /SigmaFactorBS="gagatatgtaaaccctggcaatcgtttAAATTGAAgatagca gtaaatgCAGGCTATAATAGAACTAAGaaaactatgtaccaaatgttcagtcgaaatt t" /listShort="S684, rtp" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1849038) /Source="Nicolas_upshifts" /id="U1500" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2054 /SigmaFactorBS="gagatatgtaaaccctggcaatcgtttAAATTGAAgatagca gtaaatgCAGGCTATAATAGAACTAAGaaaactatgtaccaaatgttcagtcgaaatt t" /listShort="S684, rtp" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1849040..1849136) /Source="Nicolas_S_feature" /locus_tag="new_2018435_2018531_c" /HighExp="Etha, dia15, LBGtran, LoTm, dia5, H2O2, LBGexp, M0t45, G135, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S685" promotor_-35 complement(1849064..1849071) /Source="Nicolas_upshift_promotors" /id="U1500" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2054 /SigmaFactorBS="gagatatgtaaaccctggcaatcgtttAAATTGAAgatagca gtaaatgCAGGCTATAATAGAACTAAGaaaactatgtaccaaatgttcagtcgaaatt t" /listShort="S684, rtp" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1849159..1849875) /gene="yoxD" /locus_tag="BSU_18500" /old_locus_tag="BSU18500" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15317791; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxido-reductase" /protein_id="NP_389732.1" /db_xref="EnsemblGenomes-Gn:BSU18500" /db_xref="EnsemblGenomes-Tr:CAB13743" /db_xref="GOA:P14802" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11048" /db_xref="UniProtKB/Swiss-Prot:P14802" /translation="MQSLQHKTALITGGGRGIGRATALALAKEGVNIGLIGRTSANVE KVAEEVKALGVKAAFAAADVKDADQVNQAVAQVKEQLGDIDILINNAGISKFGGFLDL SADEWENIIQVNLMGVYHVTRAVLPEMIERKAGDIINISSTAGQRGAAVTSAYSASKF AVLGLTESLMQEVRKHNIRVSALTPSTVASDMSIELNLTDGNPEKVMQPEDLAEYMVA QLKLDPRIFIKTAGLWSTNP*" /label="yoxD CDS" gene complement(1849159..1849875) /gene="yoxD" /locus_tag="BSU_18500" /old_locus_tag="BSU18500" /label="yoxD gene" downshifts complement(1849181) /Source="Nicolas_upshifts" /id="D1013" /incds=0 /nref=109 /ntot=217 /MaxReadThrough="4.9568" /MaxDrop="5.08605" /score="27.1231718" /energy="-7.5" /TU="U1501" /idTUdmin="U1500" /TUdmin="-594" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1849913..1849932) /Source="Nicolas_upshift_promotors" /id="U1501" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.772227772227772" /psig="0.996003996003996" /xcortree=2690 /SigmaFactorBS="ttaatcagaagaaatgatatttacacagttcGTTTgatttgc gtattggaTGTATTGTACTTATAATGTGatatcgtacatatgtaaacaaagaaagggt g" /listShort="yoxD, S685, S684, rtp, proH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1849922) /Source="Nicolas_upshifts" /id="U1501" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.772227772227772" /psig="0.996003996003996" /xcortree=2690 /SigmaFactorBS="ttaatcagaagaaatgatatttacacagttcGTTTgatttgc gtattggaTGTATTGTACTTATAATGTGatatcgtacatatgtaaacaaagaaagggt g" /listShort="yoxD, S685, S684, rtp, proH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1849948..1849951) /Source="Nicolas_upshift_promotors" /id="U1501" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.772227772227772" /psig="0.996003996003996" /xcortree=2690 /SigmaFactorBS="ttaatcagaagaaatgatatttacacagttcGTTTgatttgc gtattggaTGTATTGTACTTATAATGTGatatcgtacatatgtaaacaaagaaagggt g" /listShort="yoxD, S685, S684, rtp, proH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1849976..1849982 /Source="Nicolas_upshift_promotors" /id="U1502" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=228 /SigmaFactorBS="gcaaatcaaacgaactgtgtaaatatcatttcttcTGATTAA aaaaacggatacaGGGTAATGACATAAGAAAAggagtgaacatatgattatagtttat a" /listShort="yoxC, yoxB, yoaA, S686, S687" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1849996..1850014 /Source="Nicolas_upshift_promotors" /id="U1502" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=228 /SigmaFactorBS="gcaaatcaaacgaactgtgtaaatatcatttcttcTGATTAA aaaaacggatacaGGGTAATGACATAAGAAAAggagtgaacatatgattatagtttat a" /listShort="yoxC, yoxB, yoaA, S686, S687" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1850001 /Source="Nicolas_upshifts" /id="U1502" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=228 /SigmaFactorBS="gcaaatcaaacgaactgtgtaaatatcatttcttcTGATTAA aaaaacggatacaGGGTAATGACATAAGAAAAggagtgaacatatgattatagtttat a" /listShort="yoxC, yoxB, yoaA, S686, S687" /GFF_Attribute="listLong" /label="upshifts" CDS 1850026..1850331 /gene="yoxC" /locus_tag="BSU_18510" /old_locus_tag="BSU18510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16513748, 17598888; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="transition-dependent and sulfur-related metabolism protein" /protein_id="NP_389733.1" /db_xref="EnsemblGenomes-Gn:BSU18510" /db_xref="EnsemblGenomes-Tr:CAB13744" /db_xref="InterPro:IPR009293" /db_xref="SubtiList:BG11047" /db_xref="UniProtKB/Swiss-Prot:P28670" /translation="MIIVYISLAVLAVSIIFLGVTVIQNKKKIDPALKELSSVTQAMQ KQIEGLKTETELLTQKQKKIQQDVQIKKYTLQQTAAEVKEVPQAVKEVWQAGHFNSR* " /label="yoxC CDS" gene 1850026..1850331 /gene="yoxC" /locus_tag="BSU_18510" /old_locus_tag="BSU18510" /label="yoxC gene" downshifts 1850315 /Source="Nicolas_upshifts" /id="D1014" /incds=0 /nref=6 /ntot=88 /MaxReadThrough="5.31272" /MaxDrop="3.8396" /score="-9.7711365" /energy="-17.8" /TU="U1502" /idTUdmin="U1503" /TUdmin="-1473" /isTUend="FALSE" /label="downshifts" CDS 1850402..1851172 /gene="yoxB" /locus_tag="BSU_18520" /old_locus_tag="BSU18520" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11717291, 17598888, 19703276" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389734.1" /db_xref="EnsemblGenomes-Gn:BSU18520" /db_xref="EnsemblGenomes-Tr:CAB13745" /db_xref="InterPro:IPR020530" /db_xref="InterPro:IPR036895" /db_xref="SubtiList:BG11046" /db_xref="UniProtKB/Swiss-Prot:P28671" /translation="MIINRSCLKEFAEKVHFLPSSLTKSDLLTDPFRLHQENELGIYY SPHNEFINRDASLVIAGITPGFSQMKTAYETAAESLLQGGTLEQMAVDTKIAAGFSGS MRHNLITMLDLCGLPQAFGIQSAAKLFGELRHMLHTTSVIKYPVFIQQKNYTGYKPAI THSPILSTYAFGHFPAELNHVTGPALLIPLGKAAETVCETLIRQHSLQNLICLNGFPH PSGANGHRLKQFSKNKEQLERQIRSFAALVDFAIEKRK*" /label="yoxB CDS" gene 1850402..1851172 /gene="yoxB" /locus_tag="BSU_18520" /old_locus_tag="BSU18520" /label="yoxB gene" promotor_-35 1851154..1851161 /Source="Nicolas_upshift_promotors" /id="U1503" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.889110889110889" /psig="0.996003996003996" /xcortree=560 /SigmaFactorBS="gaaagacaaattcgttcctttgctgcattggttgatttcgcT ATAGAAAagaggaaataaaagGGATATGATAAACAAAAACAcaaacgtggggagtggt t" /listShort="yoaA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1851173 /Source="Nicolas_upshifts" /id="U1503" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.889110889110889" /psig="0.996003996003996" /xcortree=560 /SigmaFactorBS="gaaagacaaattcgttcctttgctgcattggttgatttcgcT ATAGAAAagaggaaataaaagGGATATGATAAACAAAAACAcaaacgtggggagtggt t" /listShort="yoaA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1851176..1851195 /Source="Nicolas_upshift_promotors" /id="U1503" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.889110889110889" /psig="0.996003996003996" /xcortree=560 /SigmaFactorBS="gaaagacaaattcgttcctttgctgcattggttgatttcgcT ATAGAAAagaggaaataaaagGGATATGATAAACAAAAACAcaaacgtggggagtggt t" /listShort="yoaA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1851216..1851749 /gene="yoaA" /locus_tag="BSU_18530" /old_locus_tag="BSU18530" /EC_number="2.3.1.-" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10482513, 11717291, 17598888; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_389735.2" /db_xref="EnsemblGenomes-Gn:BSU18530" /db_xref="EnsemblGenomes-Tr:CAB13746" /db_xref="GOA:O34569" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13472" /db_xref="UniProtKB/Swiss-Prot:O34569" /translation="MFPILETDRLILRQITDQDAEAIFACFSNDEVTRYYGLENMESI EQAISMIQTFAALYQEKRGIRWGIERRDTKELIGTIGFHALAQKHRRAEIGYEIIPEH WRNGFASEVISKVVSYGFSALGLSRIGAVVFTDNEASNRLLLKMGFQKEGVLRQYMYQ NGTPYDTNVYSIVKPRE*" /label="yoaA CDS" gene 1851216..1851749 /gene="yoaA" /locus_tag="BSU_18530" /old_locus_tag="BSU18530" /label="yoaA gene" S_feature 1851750..1851835 /Source="Nicolas_S_feature" /locus_tag="new_2021145_2021230" /HighExp="Salt, Sw, B60, LoTm, B36, M9-stat, BC, Lbstat, HiTm, Etha" /AntisenseName="yoaB" /AntisenseCor="-0.17521117067018899" /AntisenseRegPval="-2.4" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S686" downshifts 1851792 /Source="Nicolas_upshifts" /id="D1015" /incds=0 /nref=6 /ntot=100 /MaxReadThrough="4.32682" /MaxDrop="3.67936" /score="-9.7711365" /energy="-17.8" /TU="U1502" /idTUdmin="U1503" /TUdmin=4 /isTUend="TRUE" /label="downshifts" CDS complement(1851828..1853072) /gene="yoaB" /locus_tag="BSU_18540" /old_locus_tag="BSU18540" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12193636, 15849754, 16513748, 16850406, 28546427; Product type t : transporter" /codon_start=1 /transl_table=11 /product="negatively charged metabolite transporter" /protein_id="NP_389736.1" /db_xref="EnsemblGenomes-Gn:BSU18540" /db_xref="EnsemblGenomes-Tr:CAB13747" /db_xref="GOA:O34864" /db_xref="InterPro:IPR004748" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13473" /db_xref="UniProtKB/Swiss-Prot:O34864" /translation="MLDKIGIPKRLAWGFLGVVLFMMGDGLEQGWLSPFLIENGLTVQ QSASIFSIYGIALAIASWFSGVCLEAFGAKRTMFMGLLFYVIGTAAFIVFGFEQLNLP VMYVTYFVKGLGYPLFAYSFLTWVIYRTPQSKLSTAVGWFWIAYCLGMFVFGAWYSSY AIKAFGYLNTLWSSIFWVCLGAFFALFINKDRFEKKKRKRSETAEELLKGVTILFTNP RVLTGGIIRIINSIGTYGFPVFLPMHMAQHGISTNVWLQIWGTIFLGNIVFNLIFGIV GDKFGWKNTVIWFGGVGCGIFTVLLYYAPVFSGGSLAVVSVIGFIWGGLLAGYVPIGA IVPTVAGKDKGAAMSVLNLAAGLSAFVGPALAWLFIGLVGAQGVVWIFAALYLASAVL TKCIHIPEEKAVKEETSPQYAS*" /label="yoaB CDS" gene complement(1851828..1853072) /gene="yoaB" /locus_tag="BSU_18540" /old_locus_tag="BSU18540" /label="yoaB gene" S_feature 1851837..1852576 /Source="Nicolas_S_feature" /locus_tag="new_2021232_2021971" /HighExp="LoTm, Salt, Sw, S6, Etha, M9-stat, LPhT, B60, T2.0H, T2.30H" /AntisenseName="yoaB" /AntisenseCor="-0.18536963552729299" /AntisenseRegPval="-2.6" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S687" downshifts complement(1851842) /Source="Nicolas_upshifts" /id="D1016" /incds=0 /nref=32 /ntot=113 /MaxReadThrough="2.59019" /MaxDrop="4.97477" /score="29.0246554" /energy="-12.5" /TU="NA" /idTUdmin="U1504" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1853073..1853165) /Source="Nicolas_S_feature" /locus_tag="new_2022468_2022560_c" /HighExp="MG 10, MG 5, BMM, MG t5, MG 15, GM 25, HiTm, UNK1, GM 15, Gly" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S688" CDS complement(1853166..1854629) /gene="yoaC" /locus_tag="BSU_18550" /old_locus_tag="BSU18550" /EC_number="2.7.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 10094622, 12193636, 16850406, 18039762, 21749987, 27795321, 28546427; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="hydroxylated metabolite kinase" /protein_id="NP_389737.1" /db_xref="EnsemblGenomes-Gn:BSU18550" /db_xref="EnsemblGenomes-Tr:CAB13748" /db_xref="GOA:O34861" /db_xref="InterPro:IPR000577" /db_xref="InterPro:IPR018484" /db_xref="InterPro:IPR018485" /db_xref="SubtiList:BG13474" /db_xref="UniProtKB/Swiss-Prot:O34861" /translation="MKKQKGYLVFDIGTGNARVAVVSVTGSVLTVEREDIEYSTETLY PDSRYFSPQVLWKQVMNLAKRALSRSCDIDIIGLTSTSQRQGIVLIDQNGNPFLGLPN IDNRGREWEAGIPDWEEIYSSTGRLPTALFSALKLYGLKQRQPSLWEKTASFTSISDW VTYQLSGILTYEPSQATETLLFDVKQNTWSEEMCDIFGFSPSILPPLVRAGTAIGTIA NEYASELGLSINAKVIAGGGDTQLAVKSTGAGLEDIVIVSGTTTPITKITEDHGDTKH KAWLNCHTDQGHWLVETNPGITGLNYQKLKQIFYPNETYEVMEEEISALAKEDHACVA ALGSYLSAEKNALTRGGFLFDAPLSAHLKRAHFVRAALEEIAFSIKWNFDILTEVTPF ERDYVWVCGGGFQSKALTQYIADLLQKKVYVQEGYHQASVVGAAVICNETFQLTEEMS ANVRVIEPKDCQIELALYEEWKQTQRFFSGSESKVLI*" /label="yoaC CDS" gene complement(1853166..1854629) /gene="yoaC" /locus_tag="BSU_18550" /old_locus_tag="BSU18550" /label="yoaC gene" CDS complement(1854647..1855681) /gene="yoaD" /locus_tag="BSU_18560" /old_locus_tag="BSU18560" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10094622, 11390694, 12193636, 17012385, 18039762, 21749987, 27795321; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 2-hydroxyacid dehydrogenase" /protein_id="NP_389738.1" /db_xref="EnsemblGenomes-Gn:BSU18560" /db_xref="EnsemblGenomes-Tr:CAB13749" /db_xref="GOA:O34815" /db_xref="InterPro:IPR006139" /db_xref="InterPro:IPR006140" /db_xref="InterPro:IPR029753" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13475" /db_xref="UniProtKB/Swiss-Prot:O34815" /translation="MKNTMKRMFCSMTVLVTAPYNEEGRKELENLFGSVAYQSWKEQG RAYREDELIQLLKATNATGLITELDQVTDSVFASVPELSFVGVCRGMPSNVDVAAASK RGIPVFYTPGRNAQAVAEMFIGNVISFLRHTSASNQWLKDGEWDSDYLQAYVKFKGNE LTGKTVGMIGFGAVGQRIAKLLTAFDCKIKYYDPYIQDDHPLYEKASLKTVFSDSDIV SVHLPRTEETLGLIDRQYFDLMKESAIFVNTSRAVVVNREDLLFVLKEHKISGAILDV FYHEPPEESDYELISLPNVLATPHLAGATFEVEDHHVTILNKALKKWKGEKTLNIQTM YNKDALKTGG*" /label="yoaD CDS" gene complement(1854647..1855681) /gene="yoaD" /locus_tag="BSU_18560" /old_locus_tag="BSU18560" /label="yoaD gene" S_feature complement(1855693..1855764) /Source="Nicolas_S_feature" /locus_tag="new_2025088_2025159_c" /HighExp="MG t5, MG 5, MG 10, BMM, GM 25, MG 15, Heat, GM 15, MG-0.2, M9-exp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S689" downshifts complement(1855736) /Source="Nicolas_upshifts" /id="D1017" /incds=0 /nref=1 /ntot=24 /MaxReadThrough="7.78218" /MaxDrop="4.81701" /score="26.3160061" /energy="-11.4" /TU="U1504" /idTUdmin="U1507" /TUdmin=2727 /isTUend="FALSE" /label="downshifts" misc_RNA complement(1855765..1855856) /gene="mswF" /locus_tag="BSU_misc_RNA_31" /product="AdoMet riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762; Product type n: RNA" /function="16.3: Control" /label="mswF RNA" gene complement(1855765..1855856) /gene="mswF" /locus_tag="BSU_misc_RNA_31" /label="mswF gene" promotor_-10 complement(1855884..1855903) /Source="Nicolas_upshift_promotors" /id="U1504" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2890 /SigmaFactorBS="tccgatgataacgtcaattctgaaaaaaagaGATTGACAtca atctgagtcttCTTTATGATAAACGTATTCTtcattctgaaaattacatactcaatat t" /listShort="NA, S689, yoaD, yoaC, S688, yoaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1855896) /Source="Nicolas_upshifts" /id="U1504" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2890 /SigmaFactorBS="tccgatgataacgtcaattctgaaaaaaagaGATTGACAtca atctgagtcttCTTTATGATAAACGTATTCTtcattctgaaaattacatactcaatat t" /listShort="NA, S689, yoaD, yoaC, S688, yoaB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1855918..1855925) /Source="Nicolas_upshift_promotors" /id="U1504" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2890 /SigmaFactorBS="tccgatgataacgtcaattctgaaaaaaagaGATTGACAtca atctgagtcttCTTTATGATAAACGTATTCTtcattctgaaaattacatactcaatat t" /listShort="NA, S689, yoaD, yoaC, S688, yoaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1855938..1855945 /Source="Nicolas_upshift_promotors" /id="U1505" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=3069 /SigmaFactorBS="gaagactcagattgatgtcaatctctttttttcagAATTGAC GttatcatcggaaaTGTTATAATTCTTACAAAATatctaactagagagaggaactggg c" /listShort="yoaE, yoaF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1855959..1855978 /Source="Nicolas_upshift_promotors" /id="U1505" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=3069 /SigmaFactorBS="gaagactcagattgatgtcaatctctttttttcagAATTGAC GttatcatcggaaaTGTTATAATTCTTACAAAATatctaactagagagaggaactggg c" /listShort="yoaE, yoaF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1855963 /Source="Nicolas_upshifts" /id="U1505" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=3069 /SigmaFactorBS="gaagactcagattgatgtcaatctctttttttcagAATTGAC GttatcatcggaaaTGTTATAATTCTTACAAAATatctaactagagagaggaactggg c" /listShort="yoaE, yoaF" /GFF_Attribute="listLong" /label="upshifts" CDS 1856005..1858047 /gene="yoaE" /locus_tag="BSU_18570" /old_locus_tag="BSU18570" /EC_number="1.-.-.-" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 2170332, 17114254; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="molybdopterin cofactor oxido-reductase" /protein_id="NP_389739.2" /db_xref="EnsemblGenomes-Gn:BSU18570" /db_xref="EnsemblGenomes-Tr:CAB13750" /db_xref="GOA:C0SP82" /db_xref="InterPro:IPR006655" /db_xref="InterPro:IPR006656" /db_xref="InterPro:IPR006657" /db_xref="InterPro:IPR006963" /db_xref="InterPro:IPR009010" /db_xref="SubtiList:BG13476" /db_xref="UniProtKB/Swiss-Prot:C0SP82" /translation="MRSFATQQNGIFKSVCSLDCPDQCGLLIHKKDGKIVKVQGDPDH PVTAGNICNKVRNMTERIYDEKRLTTPLKRTGAKGQAIFEPISWKEAIDTITSRWKQL IDEEGAESILPYSFYGNMGKLTAEGMDRRFFYRMGSSQLERTICSKAGSEGYKYTMGI SAGIDPEETVHTKLFIFWGINAVSTNMHQITIAQKARKKGAKIVVIDVHKNQTGRLAD WFIPIKPGTDSALALGIMHILFKENLHDEAFLSEYTVGYEELREHVKQYDPEKVSTIT GVSTEDIYRLAKMYGETSPSFIRIGNGPQHHDNGGMIVRTIACLPAITGQWLHTGGGA IKHNSGILEYNTNALQRPDLLKGRTPRSFNMNQLGRVLLETDPPIRSLFIYGTNPAVV APEANKVRQGLLREDLFTVVHDLFLTETAAYADIVLPATSAFENTDFYTSYWHHYIQL QQPVIERYGESKSNTEVFRLLAEAMGFTDQELKDSDEVLIRQALDHPDNPHLAEIDYD SLTKHSFMKAKREKPLFPGELPTPSGKIELYSEKMKQDGFPALPTYTPLVTDNEHPFM YVPGPNHNFLNSTFSNNEKHIKLEKTPKLFINTKDAEKHGIVDGAPVRIWNSRGECEL TAAVGEQVLPGVVVSQGLWADEQGKKQLVNALTPDRLSDMGGGATFFSGRVQIEKV*" /label="yoaE CDS" gene 1856005..1858047 /gene="yoaE" /locus_tag="BSU_18570" /old_locus_tag="BSU18570" /label="yoaE gene" promotor_-35 1858055..1858064 /Source="Nicolas_upshift_promotors" /id="U1506" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1664 /SigmaFactorBS="aggccgtgtacagattgaaaaggtttgaaaaataaTGAAACC CGGagtatgccaagcCCGTATAACATAACATcgacataatggaggcatacacatggac g" /listShort="yoaF, S692, yozQ, S693" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1858077..1858092 /Source="Nicolas_upshift_promotors" /id="U1506" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1664 /SigmaFactorBS="aggccgtgtacagattgaaaaggtttgaaaaataaTGAAACC CGGagtatgccaagcCCGTATAACATAACATcgacataatggaggcatacacatggac g" /listShort="yoaF, S692, yozQ, S693" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1858080 /Source="Nicolas_upshifts" /id="U1506" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1664 /SigmaFactorBS="aggccgtgtacagattgaaaaggtttgaaaaataaTGAAACC CGGagtatgccaagcCCGTATAACATAACATcgacataatggaggcatacacatggac g" /listShort="yoaF, S692, yozQ, S693" /GFF_Attribute="listLong" /label="upshifts" CDS 1858114..1858407 /gene="yoaF" /locus_tag="BSU_18580" /old_locus_tag="BSU18580" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 23155385" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389740.1" /db_xref="EnsemblGenomes-Gn:BSU18580" /db_xref="EnsemblGenomes-Tr:CAB13751" /db_xref="SubtiList:BG13477" /db_xref="UniProtKB/Swiss-Prot:O31829" /translation="MDVFLGIGIALAGYFIGEGLKQRNQTKGNEQNDIFLIKERDIYF YIGLFLGITTTEAKQLAGDMADLPYIEINGKKYVQKHMLKDWTFTLVEKHQGE*" /label="yoaF CDS" gene 1858114..1858407 /gene="yoaF" /locus_tag="BSU_18580" /old_locus_tag="BSU18580" /label="yoaF gene" downshifts 1858387 /Source="Nicolas_upshifts" /id="D1018" /incds=0 /nref=97 /ntot=243 /MaxReadThrough="3.40762" /MaxDrop="4.1662" /score="-6.27063114" /energy="-3.9" /TU="U1506" /idTUdmin="U1505" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1858432..1858779) /Source="Nicolas_S_feature" /locus_tag="new_2027827_2028174_c" /HighExp="T0.30H, S0, T1.0H, aero, Etha, S8, SMMPr, T-0.40H, ferm, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S690" downshifts complement(1858463) /Source="Nicolas_upshifts" /id="D1019" /incds=0 /nref=43 /ntot=202 /MaxReadThrough="2.3171" /MaxDrop="4.25059" /score="-6.12586993" /energy="-17.4" /TU="NA" /idTUdmin="U1507" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1858780..1859184) /gene="yoaG" /locus_tag="BSU_18590" /old_locus_tag="BSU18590" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14563871, 15849754, 16850406, 20011599, 23155385; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative phage-related membrane protein" /protein_id="NP_389741.1" /db_xref="EnsemblGenomes-Gn:BSU18590" /db_xref="EnsemblGenomes-Tr:CAB13752" /db_xref="GOA:O31830" /db_xref="InterPro:IPR031374" /db_xref="SubtiList:BG13478" /db_xref="UniProtKB/Swiss-Prot:O31830" /translation="MKKIASYYLMTLGLSSLTFGLLLGFYSFVMYGDMIIALFTAAIA LLYGFVVYGLFAVPLQMKLQKKARTFNVMYLLIYSVVAFIAAFLFFVINEPASIAWTL QSYFYYMLSIAAAVIYWLWDSLILYKRTASGV*" /label="yoaG CDS" gene complement(1858780..1859184) /gene="yoaG" /locus_tag="BSU_18590" /old_locus_tag="BSU18590" /label="yoaG gene" S_feature complement(1859185..1859280) /Source="Nicolas_S_feature" /locus_tag="new_2028580_2028675_c" /HighExp="T0.30H, T1.0H, T0.0H, T-0.40H, S0, T-1.10H, T-1.40H, SMMPr, Salt, Etha" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S691" promotor_-10 complement(1859270..1859285) /Source="Nicolas_upshift_promotors" /id="U1507" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1671 /SigmaFactorBS="ccagcgtattatctaataaaagaacgtcattttTGAAACCTT TtattagcgcattGCGTATAGCACGTTAGggaagacatctcgataaaagaaatacaaa g" /listShort="S691, yoaG, S690" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(1859270..1859389) /locus_tag="BSU_18595" /old_locus_tag="BSU18595" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513962.1" /translation="MHFFHSRFGQSGEAFSASVLSNKRTSFLKPFISALRIAR*" /label="hypothetical protein CDS" gene complement(1859270..1859389) /locus_tag="BSU_18595" /old_locus_tag="BSU18595" /label="gene" upshifts complement(1859280) /Source="Nicolas_upshifts" /id="U1507" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1671 /SigmaFactorBS="ccagcgtattatctaataaaagaacgtcattttTGAAACCTT TtattagcgcattGCGTATAGCACGTTAGggaagacatctcgataaaagaaatacaaa g" /listShort="S691, yoaG, S690" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1859298..1859307) /Source="Nicolas_upshift_promotors" /id="U1507" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1671 /SigmaFactorBS="ccagcgtattatctaataaaagaacgtcattttTGAAACCTT TtattagcgcattGCGTATAGCACGTTAGggaagacatctcgataaaagaaatacaaa g" /listShort="S691, yoaG, S690" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1859385..1859391 /Source="Nicolas_upshift_promotors" /id="U1508" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=915 /SigmaFactorBS="ctgattggccaaagcgcgaatgaaaaaagTGCATGAatacct gcccaacAGACAGAATAAGaagagttgatatttcaacacttttcgtaaaggggtgaaa c" /listShort="S692, yozQ, S693" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1859405..1859416 /Source="Nicolas_upshift_promotors" /id="U1508" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=915 /SigmaFactorBS="ctgattggccaaagcgcgaatgaaaaaagTGCATGAatacct gcccaacAGACAGAATAAGaagagttgatatttcaacacttttcgtaaaggggtgaaa c" /listShort="S692, yozQ, S693" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1859416..1859624 /Source="Nicolas_S_feature" /locus_tag="new_2028811_2029019" /HighExp="S5, S8, S7, S6, S4, ferm, BT, nit, T5.0H, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99998799999999999" /TUshortSig="SigGF, SigWXY" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S692" upshifts 1859416 /Source="Nicolas_upshifts" /id="U1508" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=915 /SigmaFactorBS="ctgattggccaaagcgcgaatgaaaaaagTGCATGAatacct gcccaacAGACAGAATAAGaagagttgatatttcaacacttttcgtaaaggggtgaaa c" /listShort="S692, yozQ, S693" /GFF_Attribute="listLong" /label="upshifts" CDS 1859459..1859581 /locus_tag="BSU_18596" /old_locus_tag="BSU18596" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_009513963.1" /db_xref="EnsemblGenomes-Gn:BSU18596" /db_xref="EnsemblGenomes-Tr:CCQ48597" /db_xref="UniProtKB/TrEMBL:L8E9J0" /translation="MSKKGIQNSSIEQIRNDHETETAFKADDPKKHGSDPKRTK*" /label="conserved hypothetical protein CDS" gene 1859459..1859581 /locus_tag="BSU_18596" /old_locus_tag="BSU18596" /label="gene" CDS 1859625..1859918 /gene="yozQ" /locus_tag="BSU_18600" /old_locus_tag="BSU18600" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22882546" /codon_start=1 /transl_table=11 /product="putative sporulation protein" /protein_id="YP_054581.1" /db_xref="EnsemblGenomes-Gn:BSU18600" /db_xref="EnsemblGenomes-Tr:CAE01456" /db_xref="InterPro:IPR025100" /db_xref="SubtiList:BG14189" /db_xref="UniProtKB/Swiss-Prot:Q7WY68" /translation="MTQKNGADRPDDYKRFSSLDKEYDFQQSIRSNTETESVNTETQT HNKENKNDTTDVAGKYFEPSDYKGSTQLEKGLAETHEQVSDDYFEGTIDQNLD*" /label="yozQ CDS" gene 1859625..1859918 /gene="yozQ" /locus_tag="BSU_18600" /old_locus_tag="BSU18600" /label="yozQ gene" S_feature 1859919..1860012 /Source="Nicolas_S_feature" /locus_tag="new_2029314_2029407" /HighExp="S5, S8, S6, S7, S4, BT, ferm, nit, T5.0H, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigWXY" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S693" downshifts 1859969 /Source="Nicolas_upshifts" /id="D1020" /incds=0 /nref=14 /ntot=74 /MaxReadThrough="3.32407" /MaxDrop="3.87581" /score="-6.27063114" /energy="-3.9" /TU="U1508" /idTUdmin="U1506" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(1860034..1861719) /gene="yoaH" /locus_tag="BSU_18610" /old_locus_tag="BSU18610" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15033535, 27899502; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative methyl-accepting chemotaxis protein" /protein_id="NP_389742.2" /db_xref="EnsemblGenomes-Gn:BSU18610" /db_xref="EnsemblGenomes-Tr:CAB13753" /db_xref="GOA:C0SP89" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR004090" /db_xref="InterPro:IPR007891" /db_xref="SubtiList:BG13479" /db_xref="UniProtKB/Swiss-Prot:C0SP89" /translation="MKVKTKLLGIISILVVSIIGIGGSSVFMISSTVKKNEELKDKME FQKEIKHIQYELTGLSNDERGFLITRDKEYDEGMKGKADDVLKSLDRVNDLIDEEKYQ SNIEDIKTSFTQYRALNQQVVTAYSSNPKKAETIHFGEERTIRKEGVAPAVNKLSDRL DQEVEDLKDEIQGNGKMSQSLIIIVTGISVILGIVLSIMLLKSIMVPLRSINKQLEEI AHGEADLTKKVIVKNKDEFGQLAQSFNSFTHSLTQIVKQISSSSEQVAASSEELSASA EESKSTSEHISRAMQMAADSNVKQSSMTEKSAESITELLDSISSVASNTGNIADLSSS MRDKAEIGSKSVNKMLDQMKFIDKSVDSAGNGLQTLVASTAEISDISSLITTISEQTN LLALNAAIEAARAGEQGKGFAVVAEEVRKLADETNKSANHIQSVVATIQNESIETVNN IKVVQENVSSGIVLSQETTGNFNEILNLVEQVTSQIQEVAAATQQLTSGVEVIQHTVH TLAAGTKETSANTEAVANSSQEQLHSMGEISYAAESLSQLAEELQTVINRFKY*" /label="yoaH CDS" gene complement(1860034..1861719) /gene="yoaH" /locus_tag="BSU_18610" /old_locus_tag="BSU18610" /label="yoaH gene" downshifts complement(1860046) /Source="Nicolas_upshifts" /id="D1021" /incds=0 /nref=68 /ntot=193 /MaxReadThrough="2.22411" /MaxDrop="4.20676" /score="-6.12586993" /energy="-17.4" /TU="NA" /idTUdmin="U1509" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" S_feature complement(1861720..1861807) /Source="Nicolas_S_feature" /locus_tag="new_2031115_2031202_c" /HighExp="Cold, C30, LBGstat, GM 90, GM 15, GM 45, GM 25, GM 60, GM 10, GM 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.115923" /TUshortSig="SigD" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S694" promotor_-10 complement(1861799..1861817) /Source="Nicolas_upshift_promotors" /id="U1509" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=2825 /SigmaFactorBS="agaatttgcttattcatataagaatatcaCTATAAAActtga taacacgtGTCGATATTATGGACATGAgcgtaagcgaattggattcaaacgcgcttga a" /listShort="S694, yoaH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1861807) /Source="Nicolas_upshifts" /id="U1509" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=2825 /SigmaFactorBS="agaatttgcttattcatataagaatatcaCTATAAAActtga taacacgtGTCGATATTATGGACATGAgcgtaagcgaattggattcaaacgcgcttga a" /listShort="S694, yoaH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1861831..1861838) /Source="Nicolas_upshift_promotors" /id="U1509" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=2825 /SigmaFactorBS="agaatttgcttattcatataagaatatcaCTATAAAActtga taacacgtGTCGATATTATGGACATGAgcgtaagcgaattggattcaaacgcgcttga a" /listShort="S694, yoaH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1861976..1861985 /Source="Nicolas_upshift_promotors" /id="U1510" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1325 /SigmaFactorBS="cttattcgtttttctaaaaaaggcttttcccacctcaaattG GCTGAACCGgctgttttctcgAAAATATAATACAATACGCAgcataatatgaaggagc g" /listShort="yoaI" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1861995 /Source="Nicolas_upshifts" /id="U1510" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1325 /SigmaFactorBS="cttattcgtttttctaaaaaaggcttttcccacctcaaattG GCTGAACCGgctgttttctcgAAAATATAATACAATACGCAgcataatatgaaggagc g" /listShort="yoaI" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1861998..1862017 /Source="Nicolas_upshift_promotors" /id="U1510" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1325 /SigmaFactorBS="cttattcgtttttctaaaaaaggcttttcccacctcaaattG GCTGAACCGgctgttttctcgAAAATATAATACAATACGCAgcataatatgaaggagc g" /listShort="yoaI" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1862044..1863495 /gene="yoaI" /locus_tag="BSU_18620" /old_locus_tag="BSU18620" /EC_number="1.14.14.9" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 4-hydroxyphenylacetate-3-hydroxylase" /protein_id="NP_389743.2" /db_xref="EnsemblGenomes-Gn:BSU18620" /db_xref="EnsemblGenomes-Tr:CAB13754" /db_xref="GOA:C0SPC0" /db_xref="InterPro:IPR004925" /db_xref="InterPro:IPR009100" /db_xref="InterPro:IPR012687" /db_xref="InterPro:IPR024674" /db_xref="InterPro:IPR024719" /db_xref="InterPro:IPR036250" /db_xref="SubtiList:BG13480" /db_xref="UniProtKB/Swiss-Prot:C0SPC0" /translation="MGIINGKEFIDRLNKLENEIWYDGEKIKGNISEHPAFKGIIKTK SSLYELQTKDELIHEMTYCLPGDHNRIGLSYLQPKTKNDLKKRRTMIEHWARHTHGMM GRSPDYMNTVMMSFASSAELLKDKENCFPEHILDMYEQAAKHDLSFTHTFITPQVNRS QSYFGLSEKPISAKVIDRTEKGLMIHGARLLATQGGLTDEILVFSAPKFFFETDEAYA FSIPSNTKGVKFITRESFVLSDSSFNHPLSSRYEEMDSIVVFDHVLVPWNRVFFYDNV EAAKDFMTKSSFHAFTFHQVVIRQMIKIEFLLGVAQLLVDTINVSEYQHIQEKLSEII VGLETIKALIDKSENDAQLDEFGYMRPCLIPLQVISTIIPKLYPRFTEIIQLIGASGM VTLPTENAFDSEIREDLDQYLQATNTNAEERVKIFRLAWDLTMSSFGTRQTHYERYFF GDPIRISSRLYTSYPKQEQLNMIKTFLHADTEH*" /label="yoaI CDS" gene 1862044..1863495 /gene="yoaI" /locus_tag="BSU_18620" /old_locus_tag="BSU18620" /label="yoaI gene" downshifts 1863471 /Source="Nicolas_upshifts" /id="D1022" /incds=0 /nref=1 /ntot=19 /MaxReadThrough="2.84304" /MaxDrop="2.93575" /score="2.7297367" /energy="-12" /TU="U1510" /idTUdmin="U1510" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(1863532..1864230) /gene="exlX" /locus_tag="BSU_18630" /old_locus_tag="BSU18630" /function="16.5: Explore" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12354229, 18971341, 26751268" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 18971341, 26751268; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="extracellular endoglucanase precursor (expansin)" /protein_id="NP_389744.1" /db_xref="EnsemblGenomes-Gn:BSU18630" /db_xref="EnsemblGenomes-Tr:CAB13755" /db_xref="GOA:O34918" /db_xref="InterPro:IPR009009" /db_xref="InterPro:IPR036749" /db_xref="InterPro:IPR036908" /db_xref="PDB:2BH0" /db_xref="PDB:3D30" /db_xref="PDB:4FER" /db_xref="PDB:4FFT" /db_xref="PDB:4FG2" /db_xref="PDB:4FG4" /db_xref="SubtiList:BG13481" /db_xref="UniProtKB/Swiss-Prot:O34918" /translation="MKKIMSAFVGMVLLTIFCFSPQASAAYDDLHEGYATYTGSGYSG GAFLLDPIPSDMEITAINPADLNYGGVKAALAGSYLEVEGPKGKTTVYVTDLYPEGAR GALDLSPNAFRKIGNMKDGKINIKWRVVKAPITGNFTYRIKEGSSRWWAAIQVRNHKY PVMKMEYEKDGKWINMEKMDYNHFVSTNLGTGSLKVRMTDIRGKVVKDTIPKLPESGT SKAYTVPGHVQFPE*" /label="exlX CDS" gene complement(1863532..1864230) /gene="exlX" /locus_tag="BSU_18630" /old_locus_tag="BSU18630" /label="exlX gene" downshifts complement(1863547) /Source="Nicolas_upshifts" /id="D1023" /incds=0 /nref=6 /ntot=95 /MaxReadThrough="0.66874" /MaxDrop="3.60414" /score="1.1918692" /energy="-7.7" /TU="NA" /idTUdmin="U1511" /TUdmin=132 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1864265..1864284) /Source="Nicolas_upshift_promotors" /id="U1511" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.762237762237762" /psig="0.998001998001998" /xcortree=3161 /SigmaFactorBS="tagtgaatttgccttaaaatcaactatgaatctatttccTCT TTCAAaccagatggattgAGTCTTATAATGATAATGATtctcatttgaagtctggttt g" /listShort="exlX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1864284) /Source="Nicolas_upshifts" /id="U1511" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.762237762237762" /psig="0.998001998001998" /xcortree=3161 /SigmaFactorBS="tagtgaatttgccttaaaatcaactatgaatctatttccTCT TTCAAaccagatggattgAGTCTTATAATGATAATGATtctcatttgaagtctggttt g" /listShort="exlX" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1864286..1864499) /Source="Nicolas_S_feature" /locus_tag="new_2033681_2033894_c" /HighExp="G135, H2O2, G150, G180, LBGstat, dia15, LBGtran, Paraq, LBGexp, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S695" promotor_-35 complement(1864298..1864305) /Source="Nicolas_upshift_promotors" /id="U1511" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.762237762237762" /psig="0.998001998001998" /xcortree=3161 /SigmaFactorBS="tagtgaatttgccttaaaatcaactatgaatctatttccTCT TTCAAaccagatggattgAGTCTTATAATGATAATGATtctcatttgaagtctggttt g" /listShort="exlX" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1864500..1865177) /gene="yoaK" /locus_tag="BSU_18640" /old_locus_tag="BSU18640" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="NP_389745.1" /db_xref="EnsemblGenomes-Gn:BSU18640" /db_xref="EnsemblGenomes-Tr:CAB13756" /db_xref="GOA:O34343" /db_xref="InterPro:IPR010699" /db_xref="SubtiList:BG13482" /db_xref="UniProtKB/Swiss-Prot:O34343" /translation="MTAAAYRNTLLSLLCLTAGIVDVIGYLSLGHVFTANMTGNIVLL GLAIGKSIQVTVFNSLTALIGFICGVIIATLMVGKAENTLWPSAVTKALALEAFILFV FACLSFYRAFVPVHILIILMSISMGIQTTAAKKLGIAGISSTVLTGTLASLLEDISGR LFFKKQKKTFLRDTVLRALAIILYCVGAIIVALAEPDFYHFIIWVPIVLIFGIMMTAK LKLSGEK*" /label="yoaK CDS" gene complement(1864500..1865177) /gene="yoaK" /locus_tag="BSU_18640" /old_locus_tag="BSU18640" /label="yoaK gene" S_feature complement(1865178..1867667) /Source="Nicolas_S_feature" /locus_tag="new_2034573_2037062_c" /HighExp="LBGstat, G135, H2O2, G180, LBGtran, G150, dia15, Paraq, S0, Diami" /AntisenseName="pelB" /AntisenseCor="0.19898265589133701" /AntisenseRegPval="-3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S696" CDS 1865350..1866387 /gene="pelB" /locus_tag="BSU_18650" /old_locus_tag="BSU18650" /EC_number="4.2.2.10" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1731776, 2018526, 2185758, 7764549, 22695924; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endo-pectin lyase" /protein_id="NP_389746.1" /db_xref="EnsemblGenomes-Gn:BSU18650" /db_xref="EnsemblGenomes-Tr:CAB13757" /db_xref="GOA:O34819" /db_xref="InterPro:IPR002022" /db_xref="InterPro:IPR011050" /db_xref="InterPro:IPR012334" /db_xref="SubtiList:BG12643" /db_xref="UniProtKB/Swiss-Prot:O34819" /translation="MKRLCLWFTVFSLFLVLLPGKALGAVDFPNTSTNGLLGFAGNAK NEKGISKTGTTGGKNGQIVYIQSVNDLKTHLGGSTPKILVLQNDLSASAKTTVTIGSN KTLVGSYAKKTLKNIYLTTSSAFGNVIFQNLTFEHSPQINGNNDIQLYLDSGMNYWID HVTFSGHSYNASGSDLDKLVYIGKSADYITISNSKFANHKYGLILGYPDDSQHQYDGY PHMTIANNYFENLYVRGPGLMRYGYFHVKNNYSNNFNQAITIATKAKIYSEYNYFGKG SEKGGILDDKGTGYFKDIGSYPSLNKQTSPLTSWNPGSNYSYRVQTPEYTKEFVTKYA GSQSTTLVFGY*" /label="pelB CDS" gene 1865350..1866387 /gene="pelB" /locus_tag="BSU_18650" /old_locus_tag="BSU18650" /label="pelB gene" promotor_-35 1866584..1866590 /Source="Nicolas_upshift_promotors" /id="U1512" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=880 /SigmaFactorBS="agtgaaaagaaatcattgttctgaaccTGTATTAaatgaacg atcgtcCCACAAACTACTtaaaaacccctaaaaaggatgatggatatgtgcggcaggt t" /listShort="yoaM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1866605..1866616 /Source="Nicolas_upshift_promotors" /id="U1512" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=880 /SigmaFactorBS="agtgaaaagaaatcattgttctgaaccTGTATTAaatgaacg atcgtcCCACAAACTACTtaaaaacccctaaaaaggatgatggatatgtgcggcaggt t" /listShort="yoaM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1866617 /Source="Nicolas_upshifts" /id="U1512" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=880 /SigmaFactorBS="agtgaaaagaaatcattgttctgaaccTGTATTAaatgaacg atcgtcCCACAAACTACTtaaaaacccctaaaaaggatgatggatatgtgcggcaggt t" /listShort="yoaM" /GFF_Attribute="listLong" /label="upshifts" CDS 1866644..1867327 /gene="yoaM" /locus_tag="BSU_18660" /old_locus_tag="BSU18660" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23945014, 26070154; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative SOS response associated protein; defective prophage 6" /protein_id="NP_389747.1" /db_xref="EnsemblGenomes-Gn:BSU18660" /db_xref="EnsemblGenomes-Tr:CAB13758" /db_xref="GOA:O34906" /db_xref="InterPro:IPR003738" /db_xref="InterPro:IPR036590" /db_xref="SubtiList:BG13483" /db_xref="UniProtKB/Swiss-Prot:O34906" /translation="MCGRFTLYSAFDDIIDQFDIDQFFPKGEYQPSYNVAPSQNILAI INDGSNNRLGKLRWGLIPPWAKDEKIGYKMINARAETITEKPAFRRPLVSKRCIIPAD SFYEWKRLDSKTKIPMRIKLKSSALFAFAGLYEKWSTHQGYPLYTCTIITTEPNEFMK DIHDRMPVILAHDHEKEWLNPKNTSPDYLQSLLLPYDADDMEAYQVSSLVNSPKNNSA ELLDAENHM*" /label="yoaM CDS" gene 1866644..1867327 /gene="yoaM" /locus_tag="BSU_18660" /old_locus_tag="BSU18660" /label="yoaM gene" CDS complement(1867668..1867973) /gene="yozS" /locus_tag="BSU_18669" /old_locus_tag="BSU18669" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative permease, phage-related; defective prophage 6" /protein_id="YP_003097734.1" /db_xref="EnsemblGenomes-Gn:BSU18669" /db_xref="EnsemblGenomes-Tr:CAX52628" /db_xref="GOA:C0H420" /db_xref="UniProtKB/Swiss-Prot:C0H420" /translation="MKALIFLSSLTAIGSSILGRWLGMLDDSYAVGDAWFIGVLAGLI SLLILIDSQTMTKNYIVSLSTILGILGVGFIYFPAAFINILLSITLDKQKKEDLHVR* " /label="yozS CDS" gene complement(1867668..1867973) /gene="yozS" /locus_tag="BSU_18669" /old_locus_tag="BSU18669" /label="yozS gene" S_feature complement(1867974..1868075) /Source="Nicolas_S_feature" /locus_tag="new_2037369_2037470_c" /HighExp="HiTm, LBGstat, LBGtran, T1.30H, T1.0H, T0.30H, M9-stat, Lbstat, M0t90, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S697" promotor_-10 complement(1868054..1868073) /Source="Nicolas_upshift_promotors" /id="U1513" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=3228 /SigmaFactorBS="tttattaaatccctatatatacgttatgtagggtttttctGC TTGAATcgtattgtaatgagCTTTAAAATGTTAATGTGGAaatgaaatggtaaccatt c" /listShort="S697, yozS, S696" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1868075) /Source="Nicolas_upshifts" /id="U1513" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=3228 /SigmaFactorBS="tttattaaatccctatatatacgttatgtagggtttttctGC TTGAATcgtattgtaatgagCTTTAAAATGTTAATGTGGAaatgaaatggtaaccatt c" /listShort="S697, yozS, S696" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1868088..1868095) /Source="Nicolas_upshift_promotors" /id="U1513" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=3228 /SigmaFactorBS="tttattaaatccctatatatacgttatgtagggtttttctGC TTGAATcgtattgtaatgagCTTTAAAATGTTAATGTGGAaatgaaatggtaaccatt c" /listShort="S697, yozS, S696" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(1868103..1868205) /Source="Nicolas_S_feature" /locus_tag="new_2037498_2037600_c" /HighExp="S8, S6, S7, S5, BT, G/S, Pyr, B36, nit, SMMPr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S698" downshifts complement(1868145) /Source="Nicolas_upshifts" /id="D1024" /incds=0 /nref=9 /ntot=21 /MaxReadThrough="1.67639" /MaxDrop="3.95763" /score="-5.39979801" /energy="-8.3" /TU="NA" /idTUdmin="U1514" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1868206..1869384) /gene="oxdD" /locus_tag="BSU_18670" /old_locus_tag="BSU18670" /EC_number="4.1.1.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11546787, 14697267, 14973022, 15628860, 25526893" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11546787, 14697267, 14973022, 15628860, 25526893; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="oxalate decarboxylase (Mn2+-dependent); spore constituent" /protein_id="NP_389748.1" /db_xref="EnsemblGenomes-Gn:BSU18670" /db_xref="EnsemblGenomes-Tr:CAB13759" /db_xref="GOA:O34767" /db_xref="InterPro:IPR006045" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR017774" /db_xref="SubtiList:BG13484" /db_xref="UniProtKB/Swiss-Prot:O34767" /translation="MLLEQQPINHEDRNVPQPIRSDGAGAIDTGPRNIIRDIQNPNIF VPPVTDEGMIPNLRFSFSDAPMKLDHGGWSREITVRQLPISTAIAGVNMSLTAGGVRE LHWHKQAEWAYMLLGRARITAVDQDGRNFIADVGPGDLWYFPAGIPHSIQGLEHCEFL LVFDDGNFSEFSTLTISDWLAHTPKDVLSANFGVPENAFNSLPSEQVYIYQGNVPGSV ASEDIQSPYGKVPMTFKHELLNQPPIQMPGGSVRIVDSSNFPISKTIAAALVQIEPGA MRELHWHPNSDEWQYYLTGQGRMTVFIGNGTARTFDYRAGDVGYVPSNAGHYIQNTGT ETLWFLEMFKSNRYADVSLNQWMALTPKELVQSNLNAGSVMLDSLRKKKVPVVKYPGT *" /label="oxdD CDS" gene complement(1868206..1869384) /gene="oxdD" /locus_tag="BSU_18670" /old_locus_tag="BSU18670" /label="oxdD gene" promotor_-10 complement(1869410..1869429) /Source="Nicolas_upshift_promotors" /id="U1514" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1289 /SigmaFactorBS="tgatcacattggtggtcacttttttatttgcggattcCTAGG CACAGcaatctaagattcTGCATAGGCTGAAATAAAATcttgttcatttctaaaacga g" /listShort="yoaN, S698" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1869429) /Source="Nicolas_upshifts" /id="U1514" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1289 /SigmaFactorBS="tgatcacattggtggtcacttttttatttgcggattcCTAGG CACAGcaatctaagattcTGCATAGGCTGAAATAAAATcttgttcatttctaaaacga g" /listShort="yoaN, S698" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1869443..1869452) /Source="Nicolas_upshift_promotors" /id="U1514" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1289 /SigmaFactorBS="tgatcacattggtggtcacttttttatttgcggattcCTAGG CACAGcaatctaagattcTGCATAGGCTGAAATAAAATcttgttcatttctaaaacga g" /listShort="yoaN, S698" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1869507..1869995) /gene="yoaO" /locus_tag="BSU_18680" /old_locus_tag="BSU18680" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389749.1" /db_xref="EnsemblGenomes-Gn:BSU18680" /db_xref="EnsemblGenomes-Tr:CAB13760" /db_xref="InterPro:IPR032545" /db_xref="SubtiList:BG13485" /db_xref="UniProtKB/Swiss-Prot:O34985" /translation="MRKKNNIKKWLLIIAGFLIICIITLFVMVSGNKVKYEGSGKSGL WMSNLEKSDKTSIGPNYFLNLYWQGSKKEEKWTVVERITLYVDGEKYQDDNVDEYDLS EYTGDEMPGGGRMEDHISTFDYMPEDEVIGHDVLVKVEWRTGQKKQTEAIKLHKKPWY KK*" /label="yoaO CDS" gene complement(1869507..1869995) /gene="yoaO" /locus_tag="BSU_18680" /old_locus_tag="BSU18680" /label="yoaO gene" downshifts complement(1869532) /Source="Nicolas_upshifts" /id="D1025" /incds=0 /nref=32 /ntot=201 /MaxReadThrough="0.50319" /MaxDrop="3.84714" /score="18.561323" /energy="-9.2" /TU="NA" /idTUdmin="U1514" /TUdmin="-1387" /isTUend="FALSE" /label="downshifts" CDS complement(1870020..1870175) /locus_tag="BSU_18689" /old_locus_tag="BSU18689" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513964.1" /translation="MKQKMHLRAVIRFNLVFRKHFNLSQKFRQSSVRSLALSYFLFGN ILIVFSY*" /label="hypothetical protein CDS" gene complement(1870020..1870175) /locus_tag="BSU_18689" /old_locus_tag="BSU18689" /label="gene" CDS complement(1870215..1870970) /gene="yoaP" /locus_tag="BSU_18690" /old_locus_tag="BSU18690" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389750.1" /db_xref="EnsemblGenomes-Gn:BSU18690" /db_xref="EnsemblGenomes-Tr:CAB13761" /db_xref="GOA:O34983" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR025685" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG13486" /db_xref="UniProtKB/Swiss-Prot:O34983" /translation="MCYIEITKDNIEDNHICCALSTKQYEHAVNEKKRWLKARMDEGL VFYRLHERAKVFIEYLPANEAWVPINAPNFMYINCLWVSGRYKNNGHAKRLLDKCIAD AKACGMDGIIHIAGKKKLPYLSDKHFFEHMGFTLQDEAAPYFQLMALTWNGLADSPAF KSQVKSDSINEKGITIYYTAQCPFAVGMINDLRELTEKKGVQFQSIQLSSKEEAQKSP AIWTTFSVFFDGRFVTHEIMSINKFEKLLNTLA*" /label="yoaP CDS" gene complement(1870215..1870970) /gene="yoaP" /locus_tag="BSU_18690" /old_locus_tag="BSU18690" /label="yoaP gene" promotor_-35 1871223..1871228 /Source="Nicolas_upshift_promotors" /id="U1515" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1037 /SigmaFactorBS="agtacacgaagttttttatttgaaGTAATAtttgttacggga cagCAATAGTAAATAAGTGATAaaaggggaattaaacttggtggaaaaatgttattct t" /listShort="yoaQ, S699" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1871244..1871262 /Source="Nicolas_upshift_promotors" /id="U1515" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1037 /SigmaFactorBS="agtacacgaagttttttatttgaaGTAATAtttgttacggga cagCAATAGTAAATAAGTGATAaaaggggaattaaacttggtggaaaaatgttattct t" /listShort="yoaQ, S699" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1871259 /Source="Nicolas_upshifts" /id="U1515" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1037 /SigmaFactorBS="agtacacgaagttttttatttgaaGTAATAtttgttacggga cagCAATAGTAAATAAGTGATAaaaggggaattaaacttggtggaaaaatgttattct t" /listShort="yoaQ, S699" /GFF_Attribute="listLong" /label="upshifts" CDS 1871278..1871634 /gene="yoaQ" /locus_tag="BSU_18700" /old_locus_tag="BSU18700" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389751.1" /db_xref="EnsemblGenomes-Gn:BSU18700" /db_xref="EnsemblGenomes-Tr:CAB13762" /db_xref="SubtiList:BG13487" /db_xref="UniProtKB/Swiss-Prot:O31831" /translation="MVEKCYSCLICGYKGLIQNPLYKGEYQKTFDICPCCGFEFGYSE DHDVRLGFIVTPDHLIEAAFQLYRKQWLESGMVIAHPEDIPEELKNGNCLKFEVLLKQ LKKLNLDIENFEISGF*" /label="yoaQ CDS" gene 1871278..1871634 /gene="yoaQ" /locus_tag="BSU_18700" /old_locus_tag="BSU18700" /label="yoaQ gene" CDS complement(1871593..1871832) /gene="yozT" /locus_tag="BSU_18709" /old_locus_tag="BSU18709" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein (putative phage origin); putative defective prophage 6" /protein_id="YP_003097735.1" /db_xref="EnsemblGenomes-Gn:BSU18709" /db_xref="EnsemblGenomes-Tr:CAX52629" /db_xref="UniProtKB/Swiss-Prot:C0H421" /translation="MTVINDYREEPEEAFWILYPMGVKCLSMITKSLLNTNRDFVTDC AFQLNILLIMTVKPKQVQPVSSLKTANFKIFYVKI*" /label="yozT CDS" gene complement(1871593..1871832) /gene="yozT" /locus_tag="BSU_18709" /old_locus_tag="BSU18709" /label="yozT gene" S_feature 1871635..1872071 /Source="Nicolas_S_feature" /locus_tag="new_2041030_2041466" /HighExp="S8, S7, S4, S5, S6, S3, T5.0H, LoTm, BT, T4.0H" /AntisenseName="yozT" /AntisenseCor="0.93420248567111996" /AntisenseRegPval="-120.8" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S699" S_feature complement(1871833..1871934) /Source="Nicolas_S_feature" /locus_tag="new_2041228_2041329_c" /HighExp="S8, S7, S6, S5, S4, BT, ferm, nit, S3, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S700" CDS complement(1871935..1872432) /gene="yozF" /locus_tag="BSU_18710" /old_locus_tag="BSU18710" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_389752.2" /db_xref="EnsemblGenomes-Gn:BSU18710" /db_xref="EnsemblGenomes-Tr:CAB13763" /db_xref="SubtiList:BG13753" /db_xref="UniProtKB/Swiss-Prot:O31832" /translation="MKRVLFSVIVFTAVGFTFCQSKAHALTFTVLPITQKTDQWSVKV SEAKNVKEFTRPHKGEYQVYSLEVKNIGEKAATVDVQLYRNDPNSITRFSLFGCPDEN CVKPKEDSKMLAESLNDGSPLKFNHFMLADKASELEVVIIWTQKGQEGRNLKQTFKFT EDGVN*" /label="yozF CDS" gene complement(1871935..1872432) /gene="yozF" /locus_tag="BSU_18710" /old_locus_tag="BSU18710" /label="yozF gene" S_feature complement(1872433..1872532) /Source="Nicolas_S_feature" /locus_tag="new_2041828_2041927_c" /HighExp="S8, S7, S5, S6, S4, BT, ferm, nit, S3, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S701" CDS complement(1872533..1873444) /gene="yoaR" /locus_tag="BSU_18720" /old_locus_tag="BSU18720" /function="16.8: Protect" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8631706; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative factor for cell wall maintenance or synthesis" /protein_id="NP_389753.1" /db_xref="EnsemblGenomes-Gn:BSU18720" /db_xref="EnsemblGenomes-Tr:CAB13764" /db_xref="InterPro:IPR007391" /db_xref="SubtiList:BG13488" /db_xref="UniProtKB/Swiss-Prot:O34611" /translation="MIQILITGLFLLAQPSEPQDSLTVTQQGRTIATVNREDFTMPLP GTPMVDYEKYSKFIKQLDQKVYREPINAVLNDHGSIVPGRVGYKLYQQAFMEKFYAYF YGQGPSKIEVPEMNIYPKVDSELLAHISTQQLGQYVTYFNSSNKSRSHNISLSAKAID NHVVFPNETFSFNQVVGMRTRNKGYKSAPIIVKGELSEGVGGGICQVSSTLFNAVDRA GLQIVQRYSHTRSVPYVPPGRDATVSWGGPDFRFQNQYNQPILIRAKRYGGSMIITLY SSDVINSRLRKIPKAPSRIPKEINAEQ*" /label="yoaR CDS" gene complement(1872533..1873444) /gene="yoaR" /locus_tag="BSU_18720" /old_locus_tag="BSU18720" /label="yoaR gene" promotor_-10 complement(1873466..1873477) /Source="Nicolas_upshift_promotors" /id="U1516" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=941 /SigmaFactorBS="ctaaagattcaaacaaacgatgggaagaaaTACATCAaagga taagcggctGTTCATACTAATgattgggaggtaaaccgacttatgatacaaattttga t" /listShort="yoaR, S701, yozF, S700, yozT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1873468) /Source="Nicolas_upshifts" /id="U1516" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=941 /SigmaFactorBS="ctaaagattcaaacaaacgatgggaagaaaTACATCAaagga taagcggctGTTCATACTAATgattgggaggtaaaccgacttatgatacaaattttga t" /listShort="yoaR, S701, yozF, S700, yozT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1873492..1873498) /Source="Nicolas_upshift_promotors" /id="U1516" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=941 /SigmaFactorBS="ctaaagattcaaacaaacgatgggaagaaaTACATCAaagga taagcggctGTTCATACTAATgattgggaggtaaaccgacttatgatacaaattttga t" /listShort="yoaR, S701, yozF, S700, yozT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1873728..1873735 /Source="Nicolas_upshift_promotors" /id="U1517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.906093906093906" /psig="0.999000999001" /xcortree=2172 /SigmaFactorBS="ggtctcctataacaacaaaaaatcaatccatttcaatatttt ttTATTGAGAaacgataaatttttTGTTACATTCAATTAGACAAcaaataaatgaggt g" /listShort="yoaS, yozG, S702, yoaT, S703" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1873744 /Source="Nicolas_upshifts" /id="U1517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.906093906093906" /psig="0.999000999001" /xcortree=2172 /SigmaFactorBS="ggtctcctataacaacaaaaaatcaatccatttcaatatttt ttTATTGAGAaacgataaatttttTGTTACATTCAATTAGACAAcaaataaatgaggt g" /listShort="yoaS, yozG, S702, yoaT, S703" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1873750..1873769 /Source="Nicolas_upshift_promotors" /id="U1517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.906093906093906" /psig="0.999000999001" /xcortree=2172 /SigmaFactorBS="ggtctcctataacaacaaaaaatcaatccatttcaatatttt ttTATTGAGAaacgataaatttttTGTTACATTCAATTAGACAAcaaataaatgaggt g" /listShort="yoaS, yozG, S702, yoaT, S703" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1873791..1874273 /gene="yoaS" /locus_tag="BSU_18730" /old_locus_tag="BSU18730" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 19493340; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative toxin of a toxin / antitoxin system" /protein_id="NP_389754.1" /db_xref="EnsemblGenomes-Gn:BSU18730" /db_xref="EnsemblGenomes-Tr:CAB13765" /db_xref="GOA:O31833" /db_xref="InterPro:IPR021354" /db_xref="SubtiList:BG13489" /db_xref="UniProtKB/Swiss-Prot:O31833" /translation="MNRMSTIFLKIALVLIGIPILALCIFLVPKVANYSAELFPNIAY IKYLVFIYLYVTAIPFYFALYQAFKLLSYIDKNKAFSGLSVRALKNIKYCAVTISIFY AAGMPVFYLMAEIDDAPGIIVIGLVIIFASMVIAVFAAVLQKLLKEAIDIKSENDLTV *" /label="yoaS CDS" gene 1873791..1874273 /gene="yoaS" /locus_tag="BSU_18730" /old_locus_tag="BSU18730" /label="yoaS gene" CDS 1874283..1874537 /gene="yozG" /locus_tag="BSU_18740" /old_locus_tag="BSU18740" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 19493340; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative antitoxin of a toxin / antitoxin system; putative transcriptional regulator" /protein_id="NP_389755.1" /db_xref="EnsemblGenomes-Gn:BSU18740" /db_xref="EnsemblGenomes-Tr:CAB13766" /db_xref="GOA:O31834" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010982" /db_xref="SubtiList:BG13754" /db_xref="UniProtKB/Swiss-Prot:O31834" /translation="MAIIINIDVMLAKRKMSVTELSERVGITMANLSILKNGKAKAIR LSTLEAICKALECQPGDILEYRSDEDTGFVKKKYEGSTEK*" /label="yozG CDS" gene 1874283..1874537 /gene="yozG" /locus_tag="BSU_18740" /old_locus_tag="BSU18740" /label="yozG gene" S_feature 1874538..1874642 /Source="Nicolas_S_feature" /locus_tag="new_2043933_2044037" /HighExp="LoTm, B60, Sw, G135, G180, B36, LBGstat, Cold, LBGtran, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S702" CDS 1874643..1875437 /gene="yoaT" /locus_tag="BSU_18750" /old_locus_tag="BSU18750" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_389756.1" /db_xref="EnsemblGenomes-Gn:BSU18750" /db_xref="EnsemblGenomes-Tr:CAB13767" /db_xref="GOA:O34535" /db_xref="InterPro:IPR008535" /db_xref="SubtiList:BG13490" /db_xref="UniProtKB/Swiss-Prot:O34535" /translation="MRAIKQIVHFGWEQALSCLFPAVIFASLAITQIIPLPFLPRYDW LLIICVLMQLWMVRSGLETRDELKVITLFHLIGLALELFKVHMGSWSYPEEGYSKIFG VPLYSGFMYASVASYLCQAWRRLKVELVKWPSFFAVVPLAAAIYLNFFTHHFSIDIRW WLSGLVIIVFWQTWVTYEVNGARYRMPLALSFILIGFFIWIAENIATFFGAWKYPNQI DTWSLVHLGKVSSWLLLVIVSFLIVASLKQVKEQSPTKAEMDESFS*" /label="yoaT CDS" gene 1874643..1875437 /gene="yoaT" /locus_tag="BSU_18750" /old_locus_tag="BSU18750" /label="yoaT gene" S_feature 1875438..1876448 /Source="Nicolas_S_feature" /locus_tag="new_2044833_2045843" /HighExp="LoTm, Cold, Sw, H2O2, B60, GM 10, S8, dia15, T2.30H, MG 60" /AntisenseName="yoaU" /AntisenseCor="-2.6976304882719598E-2" /AntisenseRegPval="-0.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S703" CDS complement(1875561..1876433) /gene="yoaU" /locus_tag="BSU_18760" /old_locus_tag="BSU18760" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17526699; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (LysR family)" /protein_id="NP_389757.1" /db_xref="EnsemblGenomes-Gn:BSU18760" /db_xref="EnsemblGenomes-Tr:CAB13768" /db_xref="GOA:O34701" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13491" /db_xref="UniProtKB/Swiss-Prot:O34701" /translation="MVMNMNHLHIFVKVGEKLNITEAAKELFISQPAVSKAIKNLESS LQLKLLIRDKHHGLMLTDIGKEILLLARQMKGIESKIYQVANRENKLLNGKVKIGSFP AVSTNIMPQAIAAFRSNYPLIRIELIEGTSDQIKGWVEDRTVDIGIAASPFEPFENQL LCNDYMVAVIPPQRDELKLEKHVDLETYQDDLIFCKGGHEIAMSNAFSQYNIELKENL TVQNAETLINMVKNNLGIGIISNFTLSSVPHQLIKKDIFPRVTRDIGVIAHSFEEITP AAHEFVKVLKAVVI*" /label="yoaU CDS" gene complement(1875561..1876433) /gene="yoaU" /locus_tag="BSU_18760" /old_locus_tag="BSU18760" /label="yoaU gene" CDS 1876534..1877412 /gene="yoaV" /locus_tag="BSU_18770" /old_locus_tag="BSU18770" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10844694, 11717295, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative modified amino acid or TCA compound efflux permease" /protein_id="NP_389758.1" /db_xref="EnsemblGenomes-Gn:BSU18770" /db_xref="EnsemblGenomes-Tr:CAB13769" /db_xref="GOA:O34416" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG13492" /db_xref="UniProtKB/Swiss-Prot:O34416" /translation="MVKVMLGIISVTLIWGYTWVAMKVGIHDIPPLLFSGLRLFIGAV PLFLILFIQRKKLSIQKEHLKSYIIMSLLMGLGYMGILTYGMQFVDSGKTSVLVYTMP IFVTVISHFSLNEKMNVYKTMGLVCGLFGLLFIFGKEMLNIDQSALFGELCVLVAALS WGIANVFSKLQFKHIDIIHMNAWHLMMGAVMLLVFSFIFEAVPSAEWTYQAVWSLLFN GLLSTGFTFVVWFWVLNQIQASKASMALMFVPVLALFFGWLQLHEQITINIILGALLI CCGIFMNTFTFSRRKV*" /label="yoaV CDS" gene 1876534..1877412 /gene="yoaV" /locus_tag="BSU_18770" /old_locus_tag="BSU18770" /label="yoaV gene" S_feature complement(1877525..1877584) /Source="Nicolas_S_feature" /locus_tag="new_2046920_2046979_c" /HighExp="BC, T4.0H, M9-stat, S5, T5.0H, S4, S3, T3.0H, T3.30H, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.167154" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S704" downshifts complement(1877560) /Source="Nicolas_upshifts" /id="D1026" /incds=0 /nref=55 /ntot=175 /MaxReadThrough="1.78313" /MaxDrop="5.17096" /score="15.465237" /energy="-12.3" /TU="NA" /idTUdmin="U1518" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1877585..1878016) /gene="yoaW" /locus_tag="BSU_18780" /old_locus_tag="BSU18780" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15101989" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15101989; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="biofilm forming exported protein" /protein_id="NP_389759.1" /db_xref="EnsemblGenomes-Gn:BSU18780" /db_xref="EnsemblGenomes-Tr:CAB13770" /db_xref="SubtiList:BG13493" /db_xref="UniProtKB/Swiss-Prot:O34541" /translation="MKKMLMLAFTFLLALTIHVGEASAVIVKDEEKVSFTMTENEKWF MKSDDLNSNHWTSHFGYRFTIFDTEGCTINARIMRMTLSGYEITVSEKNFSGDHFDFS ATDRVETMPYKTHYLILTKDPDCGDVKVKGLYGFQFDQPEW*" /label="yoaW CDS" gene complement(1877585..1878016) /gene="yoaW" /locus_tag="BSU_18780" /old_locus_tag="BSU18780" /label="yoaW gene" promotor_-10 complement(1878036..1878055) /Source="Nicolas_upshift_promotors" /id="U1518" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.432567432567433" /psig=1 /xcortree=485 /SigmaFactorBS="ggtgctaaagattcatttggagaagactgTCTTGATcagaaa agaccctTCCAATATATTGAAGTAAAAgatatcgggaggaactcttttgaaaaagatg t" /listShort="yoaW" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1878044) /Source="Nicolas_upshifts" /id="U1518" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.432567432567433" /psig=1 /xcortree=485 /SigmaFactorBS="ggtgctaaagattcatttggagaagactgTCTTGATcagaaa agaccctTCCAATATATTGAAGTAAAAgatatcgggaggaactcttttgaaaaagatg t" /listShort="yoaW" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1878046..1878279) /Source="Nicolas_S_feature" /locus_tag="new_2047441_2047674_c" /HighExp="S4, S3, S5, S7, S8, S6, LoTm, T5.0H, T4.0H, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S705" promotor_-35 complement(1878069..1878075) /Source="Nicolas_upshift_promotors" /id="U1518" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.432567432567433" /psig=1 /xcortree=485 /SigmaFactorBS="ggtgctaaagattcatttggagaagactgTCTTGATcagaaa agaccctTCCAATATATTGAAGTAAAAgatatcgggaggaactcttttgaaaaagatg t" /listShort="yoaW" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1878280..1878298) /Source="Nicolas_upshift_promotors" /id="U1519" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1172 /SigmaFactorBS="gtataagctaaataagactcaaaagccTGAATAtttctttga gctaatGAATACAATAAATCGATAGaaaacactttagcagttttttgtagtgctcctg a" /listShort="S705, yoaW" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(1878280..1878912) /gene="yoaZ" /locus_tag="BSU_18790" /old_locus_tag="BSU18790" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16181642; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative factor of the oxidative stress response" /protein_id="NP_389760.1" /db_xref="EnsemblGenomes-Gn:BSU18790" /db_xref="EnsemblGenomes-Tr:CAB13771" /db_xref="GOA:O34947" /db_xref="InterPro:IPR002818" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG13494" /db_xref="UniProtKB/Swiss-Prot:O34947" /translation="MQTRKVYLYVFHTMSDWEYGYLIAELNSGRYFKQDAASLKVVTV GVNKEMITTLGGLSIKPDISLDECTLGSQDLIILPGGNTWGEDIHQPILKKVGDALKL GTTIAAICGATLGLANEGYLNSRKHTSNDLDYMNMVCPNYKGETFYEKGPAVSDENLV TASGIAPLEFAVEVLKKLDVFAPDTLRSWYKLNKTQKPEYFFELMNTINR*" /label="yoaZ CDS" gene complement(1878280..1878912) /gene="yoaZ" /locus_tag="BSU_18790" /old_locus_tag="BSU18790" /label="yoaZ gene" upshifts complement(1878286) /Source="Nicolas_upshifts" /id="U1519" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1172 /SigmaFactorBS="gtataagctaaataagactcaaaagccTGAATAtttctttga gctaatGAATACAATAAATCGATAGaaaacactttagcagttttttgtagtgctcctg a" /listShort="S705, yoaW" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1878314..1878319) /Source="Nicolas_upshift_promotors" /id="U1519" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1172 /SigmaFactorBS="gtataagctaaataagactcaaaagccTGAATAtttctttga gctaatGAATACAATAAATCGATAGaaaacactttagcagttttttgtagtgctcctg a" /listShort="S705, yoaW" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1879050..1879057 /Source="Nicolas_upshift_promotors" /id="U1520" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.84015984015984" /psig="0.999000999001" /xcortree=3062 /SigmaFactorBS="ccaacttataaaaatataagatcaattgattctaTGTTTACT agcgcaaaggggttTGTTACACTAACTGTCATGGgaaacatttcaaaggtaatacaaa a" /listShort="penP, S706" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1879072..1879091 /Source="Nicolas_upshift_promotors" /id="U1520" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.84015984015984" /psig="0.999000999001" /xcortree=3062 /SigmaFactorBS="ccaacttataaaaatataagatcaattgattctaTGTTTACT agcgcaaaggggttTGTTACACTAACTGTCATGGgaaacatttcaaaggtaatacaaa a" /listShort="penP, S706" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1879076 /Source="Nicolas_upshifts" /id="U1520" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.84015984015984" /psig="0.999000999001" /xcortree=3062 /SigmaFactorBS="ccaacttataaaaatataagatcaattgattctaTGTTTACT agcgcaaaggggttTGTTACACTAACTGTCATGGgaaacatttcaaaggtaatacaaa a" /listShort="penP, S706" /GFF_Attribute="listLong" /label="upshifts" CDS 1879138..1880058 /gene="penP" /locus_tag="BSU_18800" /old_locus_tag="BSU18800" /EC_number="3.5.2.6" /function="16.5: Explore" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7789815, 15187182, 16944130, 22211522, 25112476, 25355936; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="beta-lactamase precursor (putative hydrolase)" /protein_id="NP_389761.1" /db_xref="EnsemblGenomes-Gn:BSU18800" /db_xref="EnsemblGenomes-Tr:CAB13772" /db_xref="GOA:P39824" /db_xref="InterPro:IPR000871" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR023650" /db_xref="SubtiList:BG11016" /db_xref="UniProtKB/Swiss-Prot:P39824" /translation="MKLKTKASIKFGICVGLLCLSITGFTPFFNSTHAEAKSIEDTNM ASCITNKKFVQLEKKFDARLGVYAIDIGSNKTIAYRPNERFAYASTYKVLAAAAVLKK NSIEKLNEVIHYSKDDLVTYSPITEKHLDTGMSLKEISEAAIRYSDNTAGNILLQQLG GPKGFEKSLKQIGDHVTKAKRFETDLNSAIPGDIRDTSTAKALATDLKAFTLDNTLTT DKRMILTDWMRGNATGDELIRAGAPIGWEVGDKSGAGSYGTRNDIAIVWPPNRAPIVV AILSNRFTKDANYDNALIAEAAKVVLNDLK*" /label="penP CDS" gene 1879138..1880058 /gene="penP" /locus_tag="BSU_18800" /old_locus_tag="BSU18800" /label="penP gene" promotor_-10 complement(1879569..1879588) /Source="Nicolas_upshift_promotors" /id="U1521" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.744255744255744" /psig="0.995004995004995" /xcortree=426 /SigmaFactorBS="cagtgacttttcaaaacctttagggccgccaagcTGTTGCAA caagatgttcccagCGGTATTATCGCTGTAACGGatagccgcttccgagatttctttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1879584) /Source="Nicolas_upshifts" /id="U1521" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.744255744255744" /psig="0.995004995004995" /xcortree=426 /SigmaFactorBS="cagtgacttttcaaaacctttagggccgccaagcTGTTGCAA caagatgttcccagCGGTATTATCGCTGTAACGGatagccgcttccgagatttctttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1879603..1879610) /Source="Nicolas_upshift_promotors" /id="U1521" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.744255744255744" /psig="0.995004995004995" /xcortree=426 /SigmaFactorBS="cagtgacttttcaaaacctttagggccgccaagcTGTTGCAA caagatgttcccagCGGTATTATCGCTGTAACGGatagccgcttccgagatttctttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1880059..1880716 /Source="Nicolas_S_feature" /locus_tag="new_2049454_2050111" /HighExp="HiOs, S8, GM 25, GM 15, GM-0.1, C30, S2, S1, BC, GM 45" /AntisenseName="yobA" /AntisenseCor="8.9918765131424994E-2" /AntisenseRegPval="-0.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S706" CDS complement(1880555..1880917) /gene="yobA" /locus_tag="BSU_18810" /old_locus_tag="BSU18810" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_389762.1" /db_xref="EnsemblGenomes-Gn:BSU18810" /db_xref="EnsemblGenomes-Tr:CAB13773" /db_xref="InterPro:IPR021598" /db_xref="PDB:2JQO" /db_xref="PDB:4QY7" /db_xref="SubtiList:BG13495" /db_xref="UniProtKB/Swiss-Prot:O31835" /translation="MPKIGVSLIVLIMLIIFLAGCNKNEQNGDETKMQSLVGYVVLKD NERAILITDTKAPGKEDYNLSEGQLMNKFKNNIVIVGLSEIDNTDDLKRGEKIKVWFH TRKESNPPSATIQKYELL*" /label="yobA CDS" gene complement(1880555..1880917) /gene="yobA" /locus_tag="BSU_18810" /old_locus_tag="BSU18810" /label="yobA gene" CDS complement(1880978..1881190) /gene="yozU" /locus_tag="BSU_18819" /old_locus_tag="BSU18819" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; Product type h : extrachromosomal origin" /pseudo /codon_start=1 /transl_table=11 /product="putative phage protein" /db_xref="PSEUDO:CAX52630.1" /translation="MEVAIVNDSKDKYIYAGIQKEAAFNNIFESAKMSKRIISRATTC KYLRKNKKKVEELENEYAAVMNCKKK*" /label="yozU CDS" gene complement(1880978..1881190) /gene="yozU" /locus_tag="BSU_18819" /old_locus_tag="BSU18819" /pseudo /label="yozU gene" promotor_-35 1881229..1881236 /Source="Nicolas_upshift_promotors" /id="U1522" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig="0.967032967032967" /xcortree=487 /SigmaFactorBS="aatcgagatttttactttttttatgatccattattCACTTCC AaaataacttccaatTACAACATAATATATGTATAaattgtaaatggagttgatgtaa t" /listShort="yobB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1881251..1881270 /Source="Nicolas_upshift_promotors" /id="U1522" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig="0.967032967032967" /xcortree=487 /SigmaFactorBS="aatcgagatttttactttttttatgatccattattCACTTCC AaaataacttccaatTACAACATAATATATGTATAaattgtaaatggagttgatgtaa t" /listShort="yobB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1881254 /Source="Nicolas_upshifts" /id="U1522" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig="0.967032967032967" /xcortree=487 /SigmaFactorBS="aatcgagatttttactttttttatgatccattattCACTTCC AaaataacttccaatTACAACATAATATATGTATAaattgtaaatggagttgatgtaa t" /listShort="yobB" /GFF_Attribute="listLong" /label="upshifts" CDS 1881294..1881557 /gene="yobB" /locus_tag="BSU_18820" /old_locus_tag="BSU18820" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10376821; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator from bacteriophage; putative defective prophage 6" /protein_id="NP_389763.1" /db_xref="EnsemblGenomes-Gn:BSU18820" /db_xref="EnsemblGenomes-Tr:CAB13774" /db_xref="SubtiList:BG13496" /db_xref="UniProtKB/Swiss-Prot:O31836" /translation="MKIRKILLSSALSFGMLISAVPALAAGTSSEVAVKNEEYDYDTI YRISPLPMDFQPTIEYNGYTYTLTRHYFDYSIGFYTAIYTKVV*" /label="yobB CDS" gene 1881294..1881557 /gene="yobB" /locus_tag="BSU_18820" /old_locus_tag="BSU18820" /label="yobB gene" downshifts 1881535 /Source="Nicolas_upshifts" /id="D1027" /incds=0 /nref=23 /ntot=100 /MaxReadThrough="0.60454" /MaxDrop="4.81085" /score="19.5390064" /energy="-8.7" /TU="NA" /idTUdmin="U1522" /TUdmin=3 /isTUend="TRUE" /label="downshifts" CDS complement(1881934..1884534) /gene="yppS" /locus_tag="BSU_18830" /old_locus_tag="BSU18830" /EC_number="2.7.9.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative PEP-dependent enzyme" /protein_id="NP_389764.1" /db_xref="EnsemblGenomes-Gn:BSU18830" /db_xref="EnsemblGenomes-Tr:CAB13775" /db_xref="GOA:O34309" /db_xref="InterPro:IPR002192" /db_xref="InterPro:IPR008279" /db_xref="InterPro:IPR013815" /db_xref="SubtiList:BG12657" /db_xref="UniProtKB/Swiss-Prot:O34309" /translation="MSSLVLGLHEIEKTQLSLVGGKGLHLGELSKIQGIQVPEGFCVT TVGYQKAIEQNETLQVLLDQLTMLKVEDRDQIGNISRKIRQIIMEVDIPSDVVKAVAQ YLSQFGEEHAYAVRSSATAEDLPHASFAGQQDTYLNITGVDAILQHISKCWASLFTDR AVIYRMQNGFDHSQVYLSVIVQRMVFPQASGILFTADPITSNRKVLSIDAGFGLGEAL VSGLVSADCFKVQDGQIIDKRIATKKMAIYGRKEGGTETQQIDSDQQKAQTLTDEQIL QLARIGRQIEAHFGQPQDIEWCLARDTFYIVQSRPITTLFPIPEASDQENHVYISVGH QQMMTDPIKPLGLSFFLLTTVAPMRKAGGRLFVDVTHHLASPDSREVFLKGMGQHDQL LKDALMTIIKRRDFIKSIPNDKTAPNPSRGNADMPAQVENDPTIVSDLIESSQTSIEE LKQNIQTKSGSDLFRFILEDIQELKKILFNPKSSVLIRTAMNASLWINEKMNEWLGEK NAADTLSQSVPHNITSEMGLALLDVADVIRPYPEVIDYLQHVKDDNFLDELAKFDGGS KTRDAIYDYLSKYGMRCTGEIDITRTRWSEKPTTLVPMILNNIKNFEPNVGHRKFEQG RQEALKKEQELLDRLKQLPDGEQKAKETKRAIDIIRNFSGFREYPKYGMVNRYFVYKQ ALLKEAEQLIEAGVIHEKEDIYYLTFEELHEVVRTHKLDYQIISTRKDEYTLYEKLSP PRVITSDGEIVTGEYKRENLPAGAIVGLPVSSGVIEGRARVILNMEDADLEDGDILVT SFTDPSWTPLFVSIKGLVTEVGGLMTHGAVIAREYGLPAVVGVENAAKLIKDGQRIRV HGTEGYIEIF*" /label="yppS CDS" gene complement(1881934..1884534) /gene="yppS" /locus_tag="BSU_18830" /old_locus_tag="BSU18830" /label="yppS gene" S_feature complement(1884535..1884644) /Source="Nicolas_S_feature" /locus_tag="new_2053930_2054039_c" /HighExp="dia15, BC, S6, SMMPr, H2O2, S5, T-5.40H, S4, HPh, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S707" promotor_-35 1884560..1884567 /Source="Nicolas_upshift_promotors" /id="U1523" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=585 /SigmaFactorBS="ctcattctacatctccccttcaaaaaaaaaTATTGACAagag cttcctagcaGGATATAATAAAATTATAAGatggatatctataactttttaactagaa a" /listShort="S708" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1884582..1884601 /Source="Nicolas_upshift_promotors" /id="U1523" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=585 /SigmaFactorBS="ctcattctacatctccccttcaaaaaaaaaTATTGACAagag cttcctagcaGGATATAATAAAATTATAAGatggatatctataactttttaactagaa a" /listShort="S708" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1884590..1885217 /Source="Nicolas_S_feature" /locus_tag="new_2053985_2054612" /HighExp="T5.0H, T4.0H, T3.30H, T3.0H, S1, T2.30H, Heat, S2, T-5.40H, C30" /AntisenseName="xynA" /AntisenseCor="-0.30871986344497798" /AntisenseRegPval="-6.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S708" upshifts 1884590 /Source="Nicolas_upshifts" /id="U1523" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=585 /SigmaFactorBS="ctcattctacatctccccttcaaaaaaaaaTATTGACAagag cttcctagcaGGATATAATAAAATTATAAGatggatatctataactttttaactagaa a" /listShort="S708" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1884634..1884653) /Source="Nicolas_upshift_promotors" /id="U1524" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.41958041958042" /psig="0.999000999001" /xcortree=1451 /SigmaFactorBS="acctggtgaaatttcccaggttctttttatATTGCACaaaaa cagacacggTGATATAATCACACTACGTGcgctttctagttaaaaagttatagatatc c" /listShort="S707, pps" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1884644) /Source="Nicolas_upshifts" /id="U1524" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.41958041958042" /psig="0.999000999001" /xcortree=1451 /SigmaFactorBS="acctggtgaaatttcccaggttctttttatATTGCACaaaaa cagacacggTGATATAATCACACTACGTGcgctttctagttaaaaagttatagatatc c" /listShort="S707, pps" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1884668..1884674) /Source="Nicolas_upshift_promotors" /id="U1524" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.41958041958042" /psig="0.999000999001" /xcortree=1451 /SigmaFactorBS="acctggtgaaatttcccaggttctttttatATTGCACaaaaa cagacacggTGATATAATCACACTACGTGcgctttctagttaaaaagttatagatatc c" /listShort="S707, pps" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(1884690..1885149) /Source="Nicolas_S_feature" /locus_tag="new_2054085_2054544_c" /HighExp="S0, Lbstat, HiTm, dia0, ferm, Lbexp, T1.0H, M0t45, LBGtran, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="SigA" /TUlongPSig="0.985" /label="S709" downshifts complement(1884732) /Source="Nicolas_upshifts" /id="D1028" /incds=0 /nref=87 /ntot=200 /MaxReadThrough="1.89557" /MaxDrop="5.26144" /score="1.97345986" /energy="-10.4" /TU="NA" /idTUdmin="U1525" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1885194) /Source="Nicolas_upshifts" /id="D1029" /incds=0 /nref=2 /ntot=26 /MaxReadThrough="5.28207" /MaxDrop="3.16026" /score="1.97345986" /energy="-10.4" /TU="U1525" /idTUdmin="U1525" /TUdmin="-462" /isTUend="FALSE" /label="downshifts" CDS complement(1885204..1885845) /gene="xynA" /locus_tag="BSU_18840" /old_locus_tag="BSU18840" /EC_number="3.2.1.8" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7704256, 8628241, 16517552, 26559526" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7704256, 8628241, 16517552, 26559526; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="secreted endo-1,4-beta-xylanase" /protein_id="NP_389765.1" /db_xref="EnsemblGenomes-Gn:BSU18840" /db_xref="EnsemblGenomes-Tr:CAB13776" /db_xref="GOA:P18429" /db_xref="InterPro:IPR001137" /db_xref="InterPro:IPR013319" /db_xref="InterPro:IPR013320" /db_xref="InterPro:IPR018208" /db_xref="InterPro:IPR033119" /db_xref="InterPro:IPR033123" /db_xref="PDB:1AXK" /db_xref="PDB:1XXN" /db_xref="PDB:2B42" /db_xref="PDB:2B45" /db_xref="PDB:2B46" /db_xref="PDB:2DCY" /db_xref="PDB:2DCZ" /db_xref="PDB:2QZ3" /db_xref="PDB:2Z79" /db_xref="PDB:3EXU" /db_xref="PDB:3HD8" /db_xref="PDB:5K9Y" /db_xref="SubtiList:BG10808" /db_xref="UniProtKB/Swiss-Prot:P18429" /translation="MFKFKKNFLVGLSAALMSISLFSATASAASTDYWQNWTDGGGIV NAVNGSGGNYSVNWSNTGNFVVGKGWTTGSPFRTINYNAGVWAPNGNGYLTLYGWTRS PLIEYYVVDSWGTYRPTGTYKGTVKSDGGTYDIYTTTRYNAPSIDGDRTTFTQYWSVR QSKRPTGSNATITFSNHVNAWKSHGMNLGSNWAYQVMATEGYQSSGSSNVTVW*" /label="xynA CDS" gene complement(1885204..1885845) /gene="xynA" /locus_tag="BSU_18840" /old_locus_tag="BSU18840" /label="xynA gene" S_feature complement(1885846..1885963) /Source="Nicolas_S_feature" /locus_tag="new_2055241_2055358_c" /HighExp="S0, HiTm, T1.0H, Gly, Lbstat, SMMPr, Lbtran, LBGstat, SMM, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="SigA" /TUlongPSig="0.985" /label="S710" promotor_-10 complement(1885940..1885959) /Source="Nicolas_upshift_promotors" /id="U1525" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.656343656343656" /psig="0.995004995004995" /xcortree=2292 /SigmaFactorBS="ttataatgtgtttctaggtatttgtaattgaattacaaatac ttttaaTATttgctcatgaattCGTGGTATTATACTGAAGGGgacgatcaaaagcttt g" /listShort="S710, xynA, S709" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1885963) /Source="Nicolas_upshifts" /id="U1525" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.656343656343656" /psig="0.995004995004995" /xcortree=2292 /SigmaFactorBS="ttataatgtgtttctaggtatttgtaattgaattacaaatac ttttaaTATttgctcatgaattCGTGGTATTATACTGAAGGGgacgatcaaaagcttt g" /listShort="S710, xynA, S709" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1885973..1885975) /Source="Nicolas_upshift_promotors" /id="U1525" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.656343656343656" /psig="0.995004995004995" /xcortree=2292 /SigmaFactorBS="ttataatgtgtttctaggtatttgtaattgaattacaaatac ttttaaTATttgctcatgaattCGTGGTATTATACTGAAGGGgacgatcaaaagcttt g" /listShort="S710, xynA, S709" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1886473..1886712) /gene="yozV" /locus_tag="BSU_18849" /old_locus_tag="BSU18849" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative phage protein; putative defective prophage 6" /protein_id="YP_003097736.1" /db_xref="EnsemblGenomes-Gn:BSU18849" /db_xref="EnsemblGenomes-Tr:CAX52631" /db_xref="GOA:C0H423" /db_xref="InterPro:IPR007829" /db_xref="UniProtKB/Swiss-Prot:C0H423" /translation="MVSKKNKIVAALLAFFFGGLGIHKFYLGRVGQGILYILFCWTGI PSIIAFIEFIIFLCGSEEGFDQKYNFYYFQQQSKA*" /label="yozV CDS" gene complement(1886473..1886712) /gene="yozV" /locus_tag="BSU_18849" /old_locus_tag="BSU18849" /label="yozV gene" downshifts complement(1886493) /Source="Nicolas_upshifts" /id="D1030" /incds=0 /nref=31 /ntot=127 /MaxReadThrough="3.22282" /MaxDrop="3.97488" /score="-1.08247697" /energy="-4.5" /TU="U1526" /idTUdmin="U1526" /TUdmin="-529" /isTUend="FALSE" /label="downshifts" misc_feature complement(1886752..1886771) /Source="Nicolas_upshift_promotors" /id="U1526" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.57042957042957" /psig="0.985014985014985" /xcortree=2315 /SigmaFactorBS="taaaaaatctcaaaagaatttcaaaattttcacgatttctgg cggaaaATGCATTATAATGTGAAAGCattactttaaaaatggtagcaatgaactagga g" /listShort="yozV" /listLong="S710, xynA, S709" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1886759) /Source="Nicolas_upshifts" /id="U1526" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.57042957042957" /psig="0.985014985014985" /xcortree=2315 /SigmaFactorBS="taaaaaatctcaaaagaatttcaaaattttcacgatttctgg cggaaaATGCATTATAATGTGAAAGCattactttaaaaatggtagcaatgaactagga g" /listShort="yozV" /listLong="S710, xynA, S709" /label="upshifts" promotor_-35 1886818..1886825 /Source="Nicolas_upshift_promotors" /id="U1527" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.897102897102897" /psig="0.99100899100899" /xcortree=3063 /SigmaFactorBS="gtgaaaattttgaaattcttttgagatttttTATTTTATtga gaaatgaaagcTCATATAATTGAACTAGATGgttttgggaggcatttattcaaaatgt a" /listShort="yobD, S711, yozI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1886840..1886859 /Source="Nicolas_upshift_promotors" /id="U1527" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.897102897102897" /psig="0.99100899100899" /xcortree=3063 /SigmaFactorBS="gtgaaaattttgaaattcttttgagatttttTATTTTATtga gaaatgaaagcTCATATAATTGAACTAGATGgttttgggaggcatttattcaaaatgt a" /listShort="yobD, S711, yozI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1886847 /Source="Nicolas_upshifts" /id="U1527" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.897102897102897" /psig="0.99100899100899" /xcortree=3063 /SigmaFactorBS="gtgaaaattttgaaattcttttgagatttttTATTTTATtga gaaatgaaagcTCATATAATTGAACTAGATGgttttgggaggcatttattcaaaatgt a" /listShort="yobD, S711, yozI" /GFF_Attribute="listLong" /label="upshifts" CDS 1886883..1887221 /gene="yobD" /locus_tag="BSU_18850" /old_locus_tag="BSU18850" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10376821" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10376821; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="transcriptional regulator (phage-related, Xre family); putative defective prophage 6" /protein_id="NP_389766.1" /db_xref="EnsemblGenomes-Gn:BSU18850" /db_xref="EnsemblGenomes-Tr:CAB13777" /db_xref="GOA:O34647" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR027910" /db_xref="SubtiList:BG13497" /db_xref="UniProtKB/Swiss-Prot:O34647" /translation="MYCQRLRQLRKAHKLTMEQLAEKIGIAKSSYGGYEAESKKPPLD KLVILARLYDVSVDYILGLTDDPDPKVERKNLKEFLEKPDIHWDGYKLTPEILDPIRK ILKLVTANNN*" /label="yobD CDS" gene 1886883..1887221 /gene="yobD" /locus_tag="BSU_18850" /old_locus_tag="BSU18850" /label="yobD gene" S_feature 1887222..1887818 /Source="Nicolas_S_feature" /locus_tag="new_2056617_2057213" /HighExp="M0t90, Lbstat, Lbtran, MG 150, M40t90, MG 15, SMM, GM 25, Fru, GM-0.1" /AntisenseName="yozH" /AntisenseCor="0.41013265801279702" /AntisenseRegPval="-11.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.991" /TUlongSig="NA" /TUlongPSig="NA" /label="S711" CDS complement(1887255..1887611) /gene="yozH" /locus_tag="BSU_18860" /old_locus_tag="BSU18860" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein; putative defective prophage 6" /protein_id="NP_389767.2" /db_xref="EnsemblGenomes-Gn:BSU18860" /db_xref="EnsemblGenomes-Tr:CAB13778" /db_xref="SubtiList:BG13755" /db_xref="UniProtKB/Swiss-Prot:O31837" /translation="MNDLLFAAGNLHIGLGHDYLKCIALLINVKRFFSLTESYGNISD KLAVVAMKGVQFDQFEEAYKAYKETVAINQNSLVDFLSALITLIKAGEKLQKAGESLA IIMNKLLEMSPENSMK*" /label="yozH CDS" gene complement(1887255..1887611) /gene="yozH" /locus_tag="BSU_18860" /old_locus_tag="BSU18860" /label="yozH gene" CDS 1887819..1888184 /gene="yozI" /locus_tag="BSU_18870" /old_locus_tag="BSU18870" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein; putative defective prophage 6" /protein_id="NP_389768.1" /db_xref="EnsemblGenomes-Gn:BSU18870" /db_xref="EnsemblGenomes-Tr:CAB13779" /db_xref="SubtiList:BG13756" /db_xref="UniProtKB/Swiss-Prot:O31838" /translation="MPKLYTCLICGYKGLIQNPLNNDGEYQKTFDICPCCDFEYGYSE DHDVSLGFIVTPDYLIDAAIQLYRKQWIENGMKTANPEDIPEELRNGDCLKFEVLLKQ LNSLNLDTENFEIKGFNGY*" /label="yozI CDS" gene 1887819..1888184 /gene="yozI" /locus_tag="BSU_18870" /old_locus_tag="BSU18870" /label="yozI gene" S_feature complement(1888193..1889319) /Source="Nicolas_S_feature" /locus_tag="new_2057588_2058714_c" /HighExp="BC, Sw, HiOs, C90, Lbstat, M0t90, UNK1, M9-stat, HiTm, GM-0.1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="SigA" /TUlongPSig="0.994" /label="S712" downshifts complement(1888236) /Source="Nicolas_upshifts" /id="D1031" /incds=0 /nref=3 /ntot=99 /MaxReadThrough="3.80479" /MaxDrop="4.2268" /score="22.3776508" /energy="-7.6" /TU="U1528" /idTUdmin="U1528" /TUdmin="-513" /isTUend="FALSE" /label="downshifts" CDS 1888406..1889065 /gene="yobE" /locus_tag="BSU_18880" /old_locus_tag="BSU18880" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative SOS response associated phage protein; putative defective prophage 6" /protein_id="NP_389769.1" /db_xref="EnsemblGenomes-Gn:BSU18880" /db_xref="EnsemblGenomes-Tr:CAB13780" /db_xref="GOA:O34915" /db_xref="InterPro:IPR003738" /db_xref="InterPro:IPR036590" /db_xref="SubtiList:BG13498" /db_xref="UniProtKB/Swiss-Prot:O34915" /translation="MCGKFTLFSEFDDIIEQFNIDQFLPEGEYHPSYNVAPSQNILTI INDGSNNRLGKLRWGLIPPCAKDEKIGYKMINARAETLAEKPSFRKPLGSKRCIIPAD SFYEWKRLDPKTKIPMRIKLKSSNLFAFAGLYEKWNTLEGNLLYTCTIITIKPSELME DIHDRMPVILTDENKKEWLNPKNTDPDYLQSLLLPYDADDMEAYQVSSLVNSPELIES H*" /label="yobE CDS" gene 1888406..1889065 /gene="yobE" /locus_tag="BSU_18880" /old_locus_tag="BSU18880" /label="yobE gene" downshifts 1889143 /Source="Nicolas_upshifts" /id="D1032" /incds=0 /nref=1 /ntot=20 /MaxReadThrough="1.22982" /MaxDrop="2.96245" /score="5.95470205" /energy="-19.6" /TU="NA" /idTUdmin="U1527" /TUdmin=990 /isTUend="FALSE" /label="downshifts" CDS complement(1889320..1890243) /gene="yobF" /locus_tag="BSU_18890" /old_locus_tag="BSU18890" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389770.1" /db_xref="EnsemblGenomes-Gn:BSU18890" /db_xref="EnsemblGenomes-Tr:CAB13781" /db_xref="SubtiList:BG13499" /db_xref="UniProtKB/Swiss-Prot:O34780" /translation="MLVYIGNGHYCYSNSTAMFLSSIGENVSPQLVEILTGVGLGAMI EYEKNLYFSMRDPDDGINYALNILGFTAEEHQQASDLDDPFPLLKQQIKQNPVILGPL DMGELTYHPNHKNLNGSDHYVLGYQMDNENIYVQDPAGFPFVPLSLDQFKKAWMAERI PYRKGINKYWSTAKKVVTLDNNEIYERAIDYFKRTYRKFEKVDIGLIGREAICFYADQ LLNAPITADTIRHTTFFLFQLSARRANDYAMYFKDRHSHLSVLKTEQAKVFGICHSMS VNKDWKGISEKLMKLADLEDNFRLELLKVGY*" /label="yobF CDS" gene complement(1889320..1890243) /gene="yobF" /locus_tag="BSU_18890" /old_locus_tag="BSU18890" /label="yobF gene" promotor_-10 complement(1890099..1890118) /Source="Nicolas_upshift_promotors" /id="U1528" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.746253746253746" /psig="0.997002997002997" /xcortree=3033 /SigmaFactorBS="tctcctcaacttgtagagatattaaCTGGTGTTgggttaggt gcCATGATAGAATATGAAAAAAacctttattttagtatgagagatcctgatgatggta t" /listShort="S712" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1890102) /Source="Nicolas_upshifts" /id="U1528" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.746253746253746" /psig="0.997002997002997" /xcortree=3033 /SigmaFactorBS="tctcctcaacttgtagagatattaaCTGGTGTTgggttaggt gcCATGATAGAATATGAAAAAAacctttattttagtatgagagatcctgatgatggta t" /listShort="S712" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1890130..1890137) /Source="Nicolas_upshift_promotors" /id="U1528" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.746253746253746" /psig="0.997002997002997" /xcortree=3033 /SigmaFactorBS="tctcctcaacttgtagagatattaaCTGGTGTTgggttaggt gcCATGATAGAATATGAAAAAAacctttattttagtatgagagatcctgatgatggta t" /listShort="S712" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1890254..1890273) /Source="Nicolas_upshift_promotors" /id="U1529" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.892107892107892" /psig="0.994005994005994" /xcortree=398 /SigmaFactorBS="aaatgatccagatgatgaatacgagaacggagcaatttaaTA TGGATTttcaattttcaaaaTTGTAAGGTTAACTTATCTAcccggaggtgatgttagt g" /listShort="yobF" /listLong="S712" /label="promotor_-10" upshifts complement(1890275) /Source="Nicolas_upshifts" /id="U1529" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.892107892107892" /psig="0.994005994005994" /xcortree=398 /SigmaFactorBS="aaatgatccagatgatgaatacgagaacggagcaatttaaTA TGGATTttcaattttcaaaaTTGTAAGGTTAACTTATCTAcccggaggtgatgttagt g" /listShort="yobF" /listLong="S712" /label="upshifts" promotor_-35 complement(1890288..1890295) /Source="Nicolas_upshift_promotors" /id="U1529" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.892107892107892" /psig="0.994005994005994" /xcortree=398 /SigmaFactorBS="aaatgatccagatgatgaatacgagaacggagcaatttaaTA TGGATTttcaattttcaaaaTTGTAAGGTTAACTTATCTAcccggaggtgatgttagt g" /listShort="yobF" /listLong="S712" /label="promotor_-35" CDS complement(1890296..1890469) /gene="yozW" /locus_tag="BSU_18898" /old_locus_tag="BSU18898" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein; putative defective prophage 6" /protein_id="YP_003097737.1" /db_xref="EnsemblGenomes-Gn:BSU18898" /db_xref="EnsemblGenomes-Tr:CAX52632" /db_xref="UniProtKB/Swiss-Prot:C0H424" /translation="MTEIKANSTVMIHVLADETLSSIKREYVEVDRKTEIGEKIIIVD KNDPDDEYENGAI*" /label="yozW CDS" gene complement(1890296..1890469) /gene="yozW" /locus_tag="BSU_18898" /old_locus_tag="BSU18898" /label="yozW gene" CDS 1890614..1890838 /gene="yozX" /locus_tag="BSU_18899" /old_locus_tag="BSU18899" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative phage protein; putative defective prophage 6" /protein_id="YP_003097738.1" /db_xref="EnsemblGenomes-Gn:BSU18899" /db_xref="EnsemblGenomes-Tr:CAX52633" /db_xref="UniProtKB/Swiss-Prot:C0H425" /translation="MNFLLDLFTNWTFDKVLDYTLAAVIWSVFKSRSKQNKYPGYFEK IRRYRNLHPLLRSLSMRVLLSITIHPYMFS*" /label="yozX CDS" gene 1890614..1890838 /gene="yozX" /locus_tag="BSU_18899" /old_locus_tag="BSU18899" /label="yozX gene" CDS complement(1890842..1891297) /gene="yozJ" /locus_tag="BSU_18900" /old_locus_tag="BSU18900" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_389771.1" /db_xref="EnsemblGenomes-Gn:BSU18900" /db_xref="EnsemblGenomes-Tr:CAB13782" /db_xref="SubtiList:BG13757" /db_xref="UniProtKB/Swiss-Prot:O31839" /translation="MADRYVLIEVNEDGEGRLKDEAVTWIDFRLSIVDFNASEGLNQL MEQISKDVKDELVLVLFNYRVKSSYDSWSGATEYEDFFDVEFFKVIKKNYKKFYQGLV TVELDVGINGFDNIESMPTDSNQNYYRNLIAEWEEFYNEDFIPLSLNKR*" /label="yozJ CDS" gene complement(1890842..1891297) /gene="yozJ" /locus_tag="BSU_18900" /old_locus_tag="BSU18900" /label="yozJ gene" promotor_-35 1891357..1891364 /Source="Nicolas_upshift_promotors" /id="U1530" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.673326673326673" /psig="0.96003996003996" /xcortree=483 /SigmaFactorBS="aaatcacgattttaactatttatgatccattagtCACTTCCA aagcaacttccattTAACTCATAATTAATATATAaaatgtaaatggagttgatatatt t" /listShort="yozY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1891379..1891398 /Source="Nicolas_upshift_promotors" /id="U1530" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.673326673326673" /psig="0.96003996003996" /xcortree=483 /SigmaFactorBS="aaatcacgattttaactatttatgatccattagtCACTTCCA aagcaacttccattTAACTCATAATTAATATATAaaatgtaaatggagttgatatatt t" /listShort="yozY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1891383 /Source="Nicolas_upshifts" /id="U1530" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.673326673326673" /psig="0.96003996003996" /xcortree=483 /SigmaFactorBS="aaatcacgattttaactatttatgatccattagtCACTTCCA aagcaacttccattTAACTCATAATTAATATATAaaatgtaaatggagttgatatatt t" /listShort="yozY" /GFF_Attribute="listLong" /label="upshifts" CDS 1891422..1891682 /gene="yozY" /locus_tag="BSU_18908" /old_locus_tag="BSU18908" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator from bacteriophage; putative defective prophage 6" /protein_id="YP_003097739.1" /db_xref="EnsemblGenomes-Gn:BSU18908" /db_xref="EnsemblGenomes-Tr:CAX52634" /db_xref="UniProtKB/Swiss-Prot:C0H426" /translation="MNLRKILLSSALSLGMLVSAAPVLATSSSSEVIVKSDEYDYDTI YQLSPLPNFKPSIEYNGYTYTLTRYYFDYSIQFYTAIYTKVV*" /label="yozY CDS" gene 1891422..1891682 /gene="yozY" /locus_tag="BSU_18908" /old_locus_tag="BSU18908" /label="yozY gene" downshifts 1891629 /Source="Nicolas_upshifts" /id="D1033" /incds=0 /nref=1 /ntot=221 /MaxReadThrough="4.57606" /MaxDrop="3.58254" /score="4.613667" /energy="-8.7" /TU="U1530" /idTUdmin="U1530" /TUdmin="-638" /isTUend="FALSE" /label="downshifts" promotor_-35 1892097..1892100 /Source="Nicolas_upshift_promotors" /id="U1531" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.408591408591409" /psig="0.731268731268731" /xcortree=2853 /SigmaFactorBS="ataagagttattatatagggattacaCTACcattatctgggg gTGTATTAACATCCAAATACTcaaaagcaagaacaaatgtacccatagcacttccatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1892114..1892133 /Source="Nicolas_upshift_promotors" /id="U1531" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.408591408591409" /psig="0.731268731268731" /xcortree=2853 /SigmaFactorBS="ataagagttattatatagggattacaCTACcattatctgggg gTGTATTAACATCCAAATACTcaaaagcaagaacaaatgtacccatagcacttccatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1892131 /Source="Nicolas_upshifts" /id="U1531" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.408591408591409" /psig="0.731268731268731" /xcortree=2853 /SigmaFactorBS="ataagagttattatatagggattacaCTACcattatctgggg gTGTATTAACATCCAAATACTcaaaagcaagaacaaatgtacccatagcacttccatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 1892243 /Source="Nicolas_upshifts" /id="D1034" /incds=0 /nref=13 /ntot=69 /MaxReadThrough="3.18248" /MaxDrop="3.66335" /score="32.4789235" /energy="-13.7" /TU="U1530,U1531" /idTUdmin="U1530" /TUdmin="-24" /isTUend="FALSE" /label="downshifts" CDS 1892460..1892600 /gene="yozZ" /locus_tag="BSU_18909" /old_locus_tag="BSU18909" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /pseudo /codon_start=1 /transl_table=11 /product="putative phage holin (fragment)" /db_xref="PSEUDO:CAX52635.1" /translation="MTVFGDDLTEKFNALLTFLTALGIIVDPTTQGISDSEQAMDYDS PR*" /label="yozZ CDS" gene 1892460..1892600 /gene="yozZ" /locus_tag="BSU_18909" /old_locus_tag="BSU18909" /pseudo /label="yozZ gene" downshifts 1892597 /Source="Nicolas_upshifts" /id="D1035" /incds=0 /nref=1 /ntot=4 /MaxReadThrough="2.30104" /MaxDrop="4.04304" /score="32.4789235" /energy="-13.7" /TU="NA" /idTUdmin="U1531" /TUdmin=242 /isTUend="FALSE" /label="downshifts" promotor_-35 1892682..1892689 /Source="Nicolas_upshift_promotors" /id="U1532" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig="0.999000999001" /xcortree=2950 /SigmaFactorBS="ttttttcaaatgaaaaaattgcagaaaactttacatccttTT ACAATTttttcaatgacTATGTTATGATTGTTTTCGAgagatttttgaaattttcaga a" /listShort="rapK, phrK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1892701..1892720 /Source="Nicolas_upshift_promotors" /id="U1532" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig="0.999000999001" /xcortree=2950 /SigmaFactorBS="ttttttcaaatgaaaaaattgcagaaaactttacatccttTT ACAATTttttcaatgacTATGTTATGATTGTTTTCGAgagatttttgaaattttcaga a" /listShort="rapK, phrK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1892702 /Source="Nicolas_upshifts" /id="U1532" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig="0.999000999001" /xcortree=2950 /SigmaFactorBS="ttttttcaaatgaaaaaattgcagaaaactttacatccttTT ACAATTttttcaatgacTATGTTATGATTGTTTTCGAgagatttttgaaattttcaga a" /listShort="rapK, phrK" /GFF_Attribute="listLong" /label="upshifts" CDS 1892755..1893870 /gene="rapK" /locus_tag="BSU_18910" /old_locus_tag="BSU18910" /EC_number="3.1.-.-" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:16816200, 25225273" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16816200, 25225273; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="response regulator aspartate phosphatase" /protein_id="NP_389772.1" /db_xref="EnsemblGenomes-Gn:BSU18910" /db_xref="EnsemblGenomes-Tr:CAB13783" /db_xref="GOA:O34930" /db_xref="InterPro:IPR011990" /db_xref="SubtiList:BG12664" /db_xref="UniProtKB/Swiss-Prot:O34930" /translation="MSKIASEVVATTLNDWYIAIKKQKVDESIKYYSEIKKLFDEMEE DQEVLAYYSLLEERHKMLLHSSRGEPLQKHTYFTEDNQNFITKTNDKLEYNFYLFEAM YEAYNKNYDRAINLYGLAEKKLAEIPDEIEAAEFYSKVSYLYTLVKQSIVAQHYIKNA ISIYKRHPDYKCKLATSTMIAAANYADMKRFEEAEQYYLEAIDIAKETKDEFLKAQLF HNLSIVYSDWNKPDKCIESLEKAIGNESWLHSIYYINSLFMMIKELFKIDEKMKAINF YNKAQERLILMENKVYEAKISILYNLYCGELKNNFNNCISNIEFLKQQNELESVDELS YIAAKRFESIGAFEEATSFFNAKIWAEQKMNQVEGIL*" /label="rapK CDS" gene 1892755..1893870 /gene="rapK" /locus_tag="BSU_18910" /old_locus_tag="BSU18910" /label="rapK gene" promotor_-35 1893594..1893602 /Source="Nicolas_upshift_promotors" /id="U1533" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=505 /SigmaFactorBS="aaattgacgaaaaaatgaaagccattaatttttacaataaag cACAGGAAAGactcatattaaTGGAGAATAAAGTATACGAagccaaaatcagcatcct g" /listShort="phrK" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1893611 /Source="Nicolas_upshifts" /id="U1533" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=505 /SigmaFactorBS="aaattgacgaaaaaatgaaagccattaatttttacaataaag cACAGGAAAGactcatattaaTGGAGAATAAAGTATACGAagccaaaatcagcatcct g" /listShort="phrK" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1893614..1893632 /Source="Nicolas_upshift_promotors" /id="U1533" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=505 /SigmaFactorBS="aaattgacgaaaaaatgaaagccattaatttttacaataaag cACAGGAAAGactcatattaaTGGAGAATAAAGTATACGAagccaaaatcagcatcct g" /listShort="phrK" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1893867..1893989 /gene="phrK" /locus_tag="BSU_18920" /old_locus_tag="BSU18920" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11587781, 16816200" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11587781, 16816200; Product type r: regulator" /codon_start=1 /transl_table=11 /product="secreted regulator of the activity of phosphatase RapK" /protein_id="NP_389773.1" /db_xref="EnsemblGenomes-Gn:BSU18920" /db_xref="EnsemblGenomes-Tr:CAB13784" /db_xref="InterPro:IPR030968" /db_xref="SubtiList:BG12646" /db_xref="UniProtKB/Swiss-Prot:O31840" /translation="MKKLVLCVSILAVILSGVALTQLSTDSPSNIQVAERPVGG*" /label="phrK CDS" gene 1893867..1893989 /gene="phrK" /locus_tag="BSU_18920" /old_locus_tag="BSU18920" /label="phrK gene" downshifts 1893983 /Source="Nicolas_upshifts" /id="D1036" /incds=0 /nref=232 /ntot=252 /MaxReadThrough="2.33184" /MaxDrop="6.45227" /score="9.89565332" /energy="-10.4" /TU="NA" /idTUdmin="U1532" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1894115..1894768) /gene="yobHc" /locus_tag="BSU_18930" /old_locus_tag="BSU18930" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="fragment of putative DNA phage repair protein; putative defective prophage 6" /db_xref="EnsemblGenomes-Gn:BSU18930" /db_xref="EnsemblGenomes-Tr:CAB13785" /db_xref="GOA:C0SPA8" /db_xref="InterPro:IPR001126" /db_xref="InterPro:IPR017961" /db_xref="InterPro:IPR024728" /db_xref="InterPro:IPR036775" /db_xref="PSEUDO:CAB13785.2" /db_xref="SubtiList:BG13500" /db_xref="UniProtKB/Swiss-Prot:C0SPA8" /translation="MAKAIQSSMWREFGLMCTVGIGDNMLLSKLALDLESKKTKSGIA RWRYEDVPNRLWKVRPLSKMWGIGGRMERNLNRMGISTVGQLAKFPLELLEKKFGIMG NQLYYHAHGIDLSEIGAPLMQGQISFGKSQILFRDYTKREEIKAVLLEICEEVARRAR TYNKVGRTISLGIGYSKDELGGGFHRSKTIDFPTNITMDIYKCCLMFFNKFYSGKKQ* " /label="yobHc CDS" gene complement(1894115..1894768) /gene="yobHc" /locus_tag="BSU_18930" /old_locus_tag="BSU18930" /pseudo /label="yobHc gene" downshifts complement(1894389) /Source="Nicolas_upshifts" /id="D1037" /incds=1 /nref=1 /ntot=2 /MaxReadThrough="1.36944" /MaxDrop="2.50062" /score="17.2005818" /energy="-10" /TU="NA" /idTUdmin="U1535" /TUdmin=1628 /isTUend="FALSE" /label="downshifts" CDS complement(1894805..1895152) /gene="yobHm" /locus_tag="BSU_18940" /old_locus_tag="BSU18940" /function="16.9: Replicate" /function="16.5: Explore" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12137951; Product type h: extrachromosomal origin" /pseudo /codon_start=1 /transl_table=11 /product="putative phage DNA repair protein fragment; putative defective prophage 6" /db_xref="EnsemblGenomes-Gn:BSU18940" /db_xref="EnsemblGenomes-Tr:CAB13786" /db_xref="GOA:O31841" /db_xref="InterPro:IPR001126" /db_xref="PSEUDO:CAB13786.1" /db_xref="SubtiList:BG13758" /db_xref="UniProtKB/Swiss-Prot:O31841" /translation="MTDYSQFPRENILCVDMKSFYASVSAVAMGLNPLTCYLAVVGNT DRQGSVVLAASPALKKDFGIKTGSRLFEIPEDPRIYIVNPQMKLFIRVSTEITKLFYR FVPEKCVHTYSID*" /label="yobHm CDS" gene complement(1894805..1895152) /gene="yobHm" /locus_tag="BSU_18940" /old_locus_tag="BSU18940" /pseudo /label="yobHm gene" CDS complement(1895145..1895438) /gene="yozL" /locus_tag="BSU_18950" /old_locus_tag="BSU18950" /function="16.6: Maintain" /function="16.8: Protect" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12137951" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein of phage origin; putative defective prophage 6" /protein_id="NP_389776.1" /db_xref="EnsemblGenomes-Gn:BSU18950" /db_xref="EnsemblGenomes-Tr:CAB13787" /db_xref="InterPro:IPR014962" /db_xref="SubtiList:BG13759" /db_xref="UniProtKB/Swiss-Prot:O31842" /translation="MMLEQLIQLKQDLIDGSKVEKPSLDDKQIDEMDILVSEALEFNK ELKFKLFNKGFVENVTGRVHYINFEQQKLHVKDQNDNTVYINMNNIIRVIYND*" /label="yozL CDS" gene complement(1895145..1895438) /gene="yozL" /locus_tag="BSU_18950" /old_locus_tag="BSU18950" /label="yozL gene" upshifts 1895589 /Source="Nicolas_upshifts" /id="U1534" /multdbtbs="-" /comp="M1" /sig="SigA" /pcomp="0.340659340659341" /psig="0.65034965034965" /xcortree=472 /SigmaFactorBS="tatagatcagaacaaaagttcgatgtaaatgttggtaataaa atataaaggtcaataatgaTATCCGTAGTATTAATAAAGgagagattcttttcgacga g" /listShort="yozM" /GFF_Attribute="listLong" /label="upshifts" misc_feature 1895590..1895609 /Source="Nicolas_upshift_promotors" /id="U1534" /multdbtbs="-" /comp="M1" /sig="SigA" /pcomp="0.340659340659341" /psig="0.65034965034965" /xcortree=472 /SigmaFactorBS="tatagatcagaacaaaagttcgatgtaaatgttggtaataaa atataaaggtcaataatgaTATCCGTAGTATTAATAAAGgagagattcttttcgacga g" /listShort="yozM" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 1895647..1895982 /gene="yozM" /locus_tag="BSU_18960" /old_locus_tag="BSU18960" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative bacteriophage protein; putative defective prophage 6" /protein_id="NP_389777.1" /db_xref="EnsemblGenomes-Gn:BSU18960" /db_xref="EnsemblGenomes-Tr:CAB13788" /db_xref="SubtiList:BG13760" /db_xref="UniProtKB/Swiss-Prot:O31843" /translation="MKKRLIGFLVLVPALIMWGITLIESNKKTPVEVLESAWDEFGLF SFEIGITDPAITIGMDQTKSEAKLREYLKDNLSREAKEKYKIYIFKDDTDKLEKEHQE YLKENNLNK*" /label="yozM CDS" gene 1895647..1895982 /gene="yozM" /locus_tag="BSU_18960" /old_locus_tag="BSU18960" /label="yozM gene" promotor_no_box complement(1896021..1896121) /Source="Nicolas_upshift_promotors" /id="U1535" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.68031968031968" /psig="0.040959040959041" /xcortree=286 /SigmaFactorBS="aaagcgttggtgactgcattagagtctaaaaactacatatcc tcttttaaagaagatagagagagattacgtgtgaatactaaaaaaaaataaagaataa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" downshifts complement(1896028) /Source="Nicolas_upshifts" /id="D1038" /incds=0 /nref=148 /ntot=238 /MaxReadThrough="2.4012" /MaxDrop="4.9328" /score="17.2005818" /energy="-10" /TU="NA" /idTUdmin="U1535" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" CDS complement(1896029..1899634) /gene="yobI" /locus_tag="BSU_18970" /old_locus_tag="BSU18970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15128444; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phage repair NTPase with transmembrane helices; putative defective prophage 6" /protein_id="NP_389778.1" /db_xref="EnsemblGenomes-Gn:BSU18970" /db_xref="EnsemblGenomes-Tr:CAB13789" /db_xref="GOA:O34784" /db_xref="InterPro:IPR011646" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13501" /db_xref="UniProtKB/Swiss-Prot:O34784" /translation="MGEIKKKFVQWLEKLLIRLKEPNVKEESLFEDLSPSNDVDTDGK YSKALSWGLENKKVKNIALTGPYGSGKSSILNTFQKQYSREYSFLNISLATFNTDTDD MENKLEKSILQQMIYRVHDRTIPFSRFKRIKHIRTKSIIINLIFFFAFIIVGIYLFKP DALKGIYAETLVSRSLGTEDQQQIRLTILLALFFIVYPLLAYKRIYHFVRANLKLNKV TIANTTLEKNTGEENSSIFDKYLDEILYFFEASKYNVVIFEDLDRFNNIGIFERLREL NELINNSEQIDRRVVFIYAIKDDIFGDADTEKLTRDRTKFFDFIIPVIPIINASNSGD ILKKKIKHSPYSDLINTHFLEDVTIYIDDMRVLKNIFNEFVIYQQKLSAIDLDPNKML AMIIYKNIYPVDFSKLQYNKGLVYEIFQKKQLIIEEQIKLINAKIQQLERKLANIEVE SLKSIAELNFIYLSELEISNLNSNYDINIDGEVFRGNTSNKDRFFEKLKNADTIYCYL RNRNGPATIKEIATVFGRKPNYFEREDAIKAIEKNEIQKFKKELLELEREKQEIRAQS LQVLITKMNSKDVFSDKLYEKKLLVYLLRHGYIDEMYNHYITYFYPESLSLSDIKFVF SIKNHESLPYSFELDNIGKIMSKLVGAEFKQIEVLNFHLLNYIMDHSEYRNYYDSIIE RLANGSKESVTFIDGFKERAINKAAFIQSISSKWDDFWSFIELRSNYTQQKKEEYLSD ILTYADIADIIRMNKESVMSFTLSKYLNLLSLVSDEEKIKELLLKLQVKFKSLDHLLN SETIYDFVVQRNLYEINIKTLSVILNDAPNITYAAVKNSDQQAVINYVNDNIDIFVEK VLLTEEIEEPEESFLELLNREDLDKRVKHAMIMKKTFAISDIGELIKELWPIVIRENK MVACWSNVITSYVEYNKKMPDFLIAFLNNPVNRKELSKNNIEAFDDKFDEAILEDISE EIINSRDITDETFEVLIASIQSWIYFPLGNVSEKRAKLLIDNDLLSLTPENFKELKLN FDTLHIQLALRNPDEFIDKQGDFSLDANDIKQLIDSNELSQFNKEIFVQHLNSNCLTD GNNDILKDTIYFINEHNLKITNELLTFLLESPTTLDTRLSLLAGQIKHIDNESITEFL TKIGEPYSEIAEKGRRIKISNNRTNKALVTALESKNYISSFKEDRERLRVNTKKK*" /label="yobI CDS" gene complement(1896029..1899634) /gene="yobI" /locus_tag="BSU_18970" /old_locus_tag="BSU18970" /label="yobI gene" upshifts complement(1896061) /Source="Nicolas_upshifts" /id="U1535" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.68031968031968" /psig="0.040959040959041" /xcortree=286 /SigmaFactorBS="aaagcgttggtgactgcattagagtctaaaaactacatatcc tcttttaaagaagatagagagagattacgtgtgaatactaaaaaaaaataaagaataa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1899635..1899779) /Source="Nicolas_S_feature" /locus_tag="new_2069030_2069174_c" /HighExp="LBGstat, Lbstat, M0t90, T3.0H, T1.30H, T3.30H, MG 150, T2.30H, T4.0H, T1.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD" /TUshortPSig="1, 0.936" /TUlongSig="SigWXY" /TUlongPSig=1 /label="S713" misc_feature complement(1899772..1899791) /Source="Nicolas_upshift_promotors" /id="U1536" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=3220 /SigmaFactorBS="tgtgttgtttattgatcatctttttttcagaaacttttaatg ccctttCATGTTACAATTAATAGTGAatttcaactggcgataaaggactatattagat g" /listShort="S713, yobI" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1899779) /Source="Nicolas_upshifts" /id="U1536" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=3220 /SigmaFactorBS="tgtgttgtttattgatcatctttttttcagaaacttttaatg ccctttCATGTTACAATTAATAGTGAatttcaactggcgataaaggactatattagat g" /listShort="S713, yobI" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1899781..1899866) /Source="Nicolas_S_feature" /locus_tag="new_2069176_2069261_c" /HighExp="LBGstat, C30, Lbstat, M0t90, GM 120, GM 25, GM 150, nit, GM 90, MG 150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigWXY" /TUshortPSig="0.936, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S714" CDS complement(1899867..1900166) /gene="yoyA" /locus_tag="BSU_18979" /old_locus_tag="BSU18979" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; Product type h : extrachromosomal origin" /pseudo /codon_start=1 /transl_table=11 /product="putative fragment of phage protein; putative defective prophage 6" /db_xref="PSEUDO:CAX52636.1" /translation="MATEGYGGNNSAPSRSIGFSEFCETLEKNEVVKPENKKSSLDLN NSLDYWKSRFNPGGNLSALDSQVLDIIKKAYNLGMVNKDNMLLRNEAINAYKNSI*" /label="yoyA CDS" gene complement(1899867..1900166) /gene="yoyA" /locus_tag="BSU_18979" /old_locus_tag="BSU18979" /pseudo /label="yoyA gene" S_feature complement(1900167..1900304) /Source="Nicolas_S_feature" /locus_tag="new_2069562_2069699_c" /HighExp="LBGstat, C30, MG 150, GM 150, M0t90, Lbstat, GM 25, GM 90, GM 120, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigWXY" /TUshortPSig="0.936, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S715" promotor_-10 complement(1900282..1900300) /Source="Nicolas_upshift_promotors" /id="U1537" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.936063936063936" /psig="0.936063936063936" /xcortree=3232 /SigmaFactorBS="gtgaaaggaacttgcaaaatgcaggttcttttttgtattcaa ttATTAAATcatttgaatgattGTCGATATTTAATATGTGTaaaaatggaaaaggtgc t" /listShort="S715, yoyA, S714, S713, yobI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1900304) /Source="Nicolas_upshifts" /id="U1537" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.936063936063936" /psig="0.936063936063936" /xcortree=3232 /SigmaFactorBS="gtgaaaggaacttgcaaaatgcaggttcttttttgtattcaa ttATTAAATcatttgaatgattGTCGATATTTAATATGTGTaaaaatggaaaaggtgc t" /listShort="S715, yoyA, S714, S713, yobI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1900314..1900320) /Source="Nicolas_upshift_promotors" /id="U1537" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.936063936063936" /psig="0.936063936063936" /xcortree=3232 /SigmaFactorBS="gtgaaaggaacttgcaaaatgcaggttcttttttgtattcaa ttATTAAATcatttgaatgattGTCGATATTTAATATGTGTaaaaatggaaaaggtgc t" /listShort="S715, yoyA, S714, S713, yobI" /GFF_Attribute="listLong" /label="promotor_-35" misc_RNA complement(1900337..1900720) /gene="asrE" /locus_tag="BSU_misc_RNA_74" /product="small regulatory antitoxin RNA, toxin-antitoxin type I system (BsrE/AsrE)" /experiment="publication(s) with functional evidences, PMID:18948176, 23059907, 24576839, 26565032, 26940229" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18948176, 23059907, 24576839, 26565032, 26940229; Product type n: RNA" /label="asrE RNA" gene complement(1900337..1900720) /gene="asrE" /locus_tag="BSU_misc_RNA_74" /label="asrE gene" S_feature complement(1900351..1900587) /Source="Nicolas_S_feature" /locus_tag="new_2069746_2069982_c" /HighExp="Salt, Etha, S4, LoTm, dia5, Diami, S5, MG 120, S3, aero" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigWXY" /TUshortPSig="0.518, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S716" promotor_-35 1900384..1900386 /Source="Nicolas_upshift_promotors" /id="U1538" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.774225774225774" /psig=1 /xcortree=474 /SigmaFactorBS="tttgcaagttcctttcacgttgtcaatatattgtgaaTTTtt aacgacaagggcaTTTATGTATAGTATGATATTtcctgtacagtaagttttgctcact c" /listShort="S717" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(1900394) /Source="Nicolas_upshifts" /id="D1039" /incds=0 /nref=39 /ntot=216 /MaxReadThrough="3.37292" /MaxDrop="5.0558" /score="17.2005818" /energy="-10" /TU="U1541" /idTUdmin="U1539" /TUdmin=1 /isTUend="TRUE" /label="downshifts" promotor_-10 1900402..1900421 /Source="Nicolas_upshift_promotors" /id="U1538" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.774225774225774" /psig=1 /xcortree=474 /SigmaFactorBS="tttgcaagttcctttcacgttgtcaatatattgtgaaTTTtt aacgacaagggcaTTTATGTATAGTATGATATTtcctgtacagtaagttttgctcact c" /listShort="S717" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1900407 /Source="Nicolas_upshifts" /id="U1538" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.774225774225774" /psig=1 /xcortree=474 /SigmaFactorBS="tttgcaagttcctttcacgttgtcaatatattgtgaaTTTtt aacgacaagggcaTTTATGTATAGTATGATATTtcctgtacagtaagttttgctcact c" /listShort="S717" /GFF_Attribute="listLong" /label="upshifts" S_feature 1900429..1900582 /Source="Nicolas_S_feature" /locus_tag="new_2069824_2069977" /HighExp="T1.30H, B60, T2.0H, M9-stat, BT, T0.30H, B36, T1.0H, T3.0H, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.87861900000000004" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S717" CDS 1900488..1900580 /gene="bsrE" /locus_tag="BSU_18978" /old_locus_tag="BSU18978" /experiment="publication(s) with functional evidences, PMID:26565032, 26940229" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 26565032, 26940229; Product type f: factor" /codon_start=1 /transl_table=11 /product="type I toxin (BsrE/AsrE)" /protein_id="YP_009513965.1" /translation="MSTFQALMLMLAIGSFIIALLTYIEKIDLP*" /label="bsrE CDS" gene 1900488..1900580 /gene="bsrE" /locus_tag="BSU_18978" /old_locus_tag="BSU18978" /label="bsrE gene" downshifts 1900539 /Source="Nicolas_upshifts" /id="D1040" /incds=0 /nref=1 /ntot=6 /MaxReadThrough="6.71009" /MaxDrop="3.13767" /score="33.1812693" /energy="-14.4" /TU="U1538" /idTUdmin="U1538" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" S_feature complement(1900589..1900723) /Source="Nicolas_S_feature" /locus_tag="new_2069984_2070118_c" /HighExp="T-0.40H, T0.0H, T0.30H, Salt, S4, M9-stat, T-1.10H, S7, B60, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigWXY" /TUshortPSig="0.518, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S718" downshifts 1900605 /Source="Nicolas_upshifts" /id="D1041" /incds=0 /nref=135 /ntot=196 /MaxReadThrough="2.41468" /MaxDrop="5.72925" /score="33.1812693" /energy="-14.4" /TU="NA" /idTUdmin="U1538" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1900632) /Source="Nicolas_upshifts" /id="D1042" /incds=0 /nref=13 /ntot=114 /MaxReadThrough="6.34283" /MaxDrop="4.1536" /score="3.24083135" /energy="-14.3" /TU="U1539,U1541" /idTUdmin="U1539" /TUdmin="-237" /isTUend="FALSE" /label="downshifts" upshifts complement(1900723) /Source="Nicolas_upshifts" /id="U1539" /multdbtbs="-" /comp="M3" /sig="SigA" /pcomp="0.44955044955045" /psig="0.518481518481518" /xcortree=755 /SigmaFactorBS="cttgaggtttattgtaatgcatttcacggaaaatgtgttata atcagtttTAcaatacattacagtgcatttctttaatgagaaatgcataaaataaaaa a" /listShort="S718, S716" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1900725..1900848) /Source="Nicolas_S_feature" /locus_tag="new_2070120_2070243_c" /HighExp="T-0.40H, T0.0H, T0.30H, Salt, T-1.10H, T1.0H, T-1.40H, Etha, SMMPr, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S719" misc_feature complement(1900732..1900733) /Source="Nicolas_upshift_promotors" /id="U1539" /multdbtbs="-" /comp="M3" /sig="SigA" /pcomp="0.44955044955045" /psig="0.518481518481518" /xcortree=755 /SigmaFactorBS="cttgaggtttattgtaatgcatttcacggaaaatgtgttata atcagtttTAcaatacattacagtgcatttctttaatgagaaatgcataaaataaaaa a" /listShort="S718, S716" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(1900849..1901691) /gene="yobJ" /locus_tag="BSU_18980" /old_locus_tag="BSU18980" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11866510" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function; putative defective prophage 6" /protein_id="NP_389779.1" /db_xref="EnsemblGenomes-Gn:BSU18980" /db_xref="EnsemblGenomes-Tr:CAB13790" /db_xref="GOA:O34774" /db_xref="SubtiList:BG13502" /db_xref="UniProtKB/Swiss-Prot:O34774" /translation="MELLDIWNWIQQNGILTAVITGIVALLFNQRQKSIERFYSQSGE TLEKILEPMYYSLKEIKNEEDENHKMVLIEKFFEEYSGKKGKLSKLRNILLIDQILNT EDCFREYILNKNSENRKKLFYKMRMLDQAVNKEYRSIFVTLNKNYNWYKVLFRTNYIL SAVFVFVRWFKETLAFFVGASAFAFIPLLYDKYLGEQVLGNWLEVNKLIFGLSCSALY IFWIIHYFLLKDTMQRKDEISLFQEWFDKTKLGKWTNKNVWGKIGNWNVERRARRVRN DEDV*" /label="yobJ CDS" gene complement(1900849..1901691) /gene="yobJ" /locus_tag="BSU_18980" /old_locus_tag="BSU18980" /label="yobJ gene" promotor_-35 1901186..1901189 /Source="Nicolas_upshift_promotors" /id="U1540" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.978021978021978" /psig="0.011988011988012" /xcortree=47 /SigmaFactorBS="aagcaaatgctgaagcaccgacaaaaaaagctagagtttctt taaacCATCtaacaaaaacaaaaaCAGCGcttaaaatataattcgttctaaaaagaac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1901199 /Source="Nicolas_upshifts" /id="U1540" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.978021978021978" /psig="0.011988011988012" /xcortree=47 /SigmaFactorBS="aagcaaatgctgaagcaccgacaaaaaaagctagagtttctt taaacCATCtaacaaaaacaaaaaCAGCGcttaaaatataattcgttctaaaaagaac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1901205..1901209 /Source="Nicolas_upshift_promotors" /id="U1540" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.978021978021978" /psig="0.011988011988012" /xcortree=47 /SigmaFactorBS="aagcaaatgctgaagcaccgacaaaaaaagctagagtttctt taaacCATCtaacaaaaacaaaaaCAGCGcttaaaatataattcgttctaaaaagaac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1901717..1901732) /Source="Nicolas_upshift_promotors" /id="U1541" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1677 /SigmaFactorBS="agaagttttctagtcccgttttataTGAAACCTTTtttattt tagcCCGTATTAAAAGTAAAttcagagagaaggggagaagcttaattggagttattag a" /listShort="yobJ, S719, S718, S716, S715, yoyA, S714" /listLong="S713, yobI" /label="promotor_-10" upshifts complement(1901718) /Source="Nicolas_upshifts" /id="U1541" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1677 /SigmaFactorBS="agaagttttctagtcccgttttataTGAAACCTTTtttattt tagcCCGTATTAAAAGTAAAttcagagagaaggggagaagcttaattggagttattag a" /listShort="yobJ, S719, S718, S716, S715, yoyA, S714" /listLong="S713, yobI" /label="upshifts" S_feature complement(1901720..1901802) /Source="Nicolas_S_feature" /locus_tag="new_2071115_2071197_c" /HighExp="MG 150, T-3.40H, Cold, SMM, Lbstat, SMMPr, ferm, T-2.40H, Fru, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S720" promotor_-35 complement(1901744..1901753) /Source="Nicolas_upshift_promotors" /id="U1541" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1677 /SigmaFactorBS="agaagttttctagtcccgttttataTGAAACCTTTtttattt tagcCCGTATTAAAAGTAAAttcagagagaaggggagaagcttaattggagttattag a" /listShort="yobJ, S719, S718, S716, S715, yoyA, S714" /listLong="S713, yobI" /label="promotor_-35" S_feature complement(1901804..1901890) /Source="Nicolas_S_feature" /locus_tag="new_2071199_2071285_c" /HighExp="Lbstat, M0t90, HiOs, HiTm, M40t90, dia15, S2, S1, T-0.40H, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S721" downshifts complement(1901847) /Source="Nicolas_upshifts" /id="D1043" /incds=0 /nref=5 /ntot=191 /MaxReadThrough="4.07519" /MaxDrop="4.09712" /score="-3.79237769" /energy="-8.4" /TU="U1542" /idTUdmin="U1542" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" CDS complement(1901891..1902349) /gene="rttM" /locus_tag="BSU_18990" /old_locus_tag="BSU18990" /function="17.2: Prophage functions" /experiment="publication(s) with functional evidences, PMID:22200572" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22200572; Product type f: factor" /codon_start=1 /transl_table=11 /product="antitoxin inhibiting Rnase RttL" /protein_id="NP_389780.1" /db_xref="EnsemblGenomes-Gn:BSU18990" /db_xref="EnsemblGenomes-Tr:CAB13791" /db_xref="InterPro:IPR018958" /db_xref="PDB:2PRV" /db_xref="SubtiList:BG13503" /db_xref="UniProtKB/Swiss-Prot:O34596" /translation="MIYSKVENFINENKQNAIFTEGASHENIGRIEENLQCDLPNSYK WFLEKYGAGGLFGVLVLGYNFDHASVVNRTNEYKEHYGLTDGLVVIEDVDYFAYCLDT NKMKDGECPVVEWDRVIGYQDTVADSFIEFFYNKIQEAKDDWDEDEDWDD*" /label="rttM CDS" gene complement(1901891..1902349) /gene="rttM" /locus_tag="BSU_18990" /old_locus_tag="BSU18990" /label="rttM gene" CDS complement(1902359..1904161) /gene="rttL" /locus_tag="BSU_19000" /old_locus_tag="BSU19000" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:22200572" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22200572; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phage toxin ribonuclease; putative defective prophage 6" /protein_id="NP_389781.1" /db_xref="EnsemblGenomes-Gn:BSU19000" /db_xref="EnsemblGenomes-Tr:CAB13792" /db_xref="GOA:O34330" /db_xref="InterPro:IPR006829" /db_xref="InterPro:IPR026834" /db_xref="SubtiList:BG13504" /db_xref="UniProtKB/Swiss-Prot:O34330" /translation="MKVFEADSLLFEADKRTKEYKELRSQMVKLKKAFKEVANLDDSE FSGKGADNIKAFYHGHVGVTDQWIDLIDMKIAFLSSMSATLEDAKMSDAYIEESFLEH ELANAYAKSKSIMSEQKKAMKDILNNINDILPLEIFSTEDFKDKLSSADDKREKTIDK LNKLDEDLKTEYAETEPNEQFIQQDFKKLQESTGKGKNATPIHYNAKAYRESDIHKKK GDIEKHSEAYLSVKKEEAKEREIKELKKKLNDGVSDPDEYLEIAKKVGYENLEPTQVQ LAVQIEQAKQLEGAGEITWDIVKGVGVGLYDVGKDTVTGIWDFITDPGETLSALGNAA MHPVKTYDAISAAIEESYQKDMVNGDAYSRSRWVTYAIGSVAVAVVGTKGAGAINKAD AAGKVINKASQAGKKIKDVKIPDLLPYNPKYKLALADNVPYNVVDSQNLKNELLTNAK KIPDGTRKPFTGQKKSPPWLNKEKYDAYEIEGKVKAKGKVKDVSRRVYTMKDIDINQK TEFGVTNLQLMKNGNAPYAKDGTQINLHHLIQEEPGPMLEIPNSLHTKYSDVIHQLKS DGESFRNDKVLKAQYESFRKRYWKWRAKQFENEN*" /label="rttL CDS" gene complement(1902359..1904161) /gene="rttL" /locus_tag="BSU_19000" /old_locus_tag="BSU19000" /label="rttL gene" promotor_-10 complement(1904185..1904204) /Source="Nicolas_upshift_promotors" /id="U1542" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=3217 /SigmaFactorBS="gtgtgatgtataagacagtcattttggctgtctttttcTGTT ATTCaattagattacTGTGGTAAAATTTACATAGAagtagtctaggaaggagaatgat a" /listShort="yobL, yobK, S721, S720" /listLong="yobJ, S719, S718, S716" /label="promotor_-10" upshifts complement(1904201) /Source="Nicolas_upshifts" /id="U1542" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=3217 /SigmaFactorBS="gtgtgatgtataagacagtcattttggctgtctttttcTGTT ATTCaattagattacTGTGGTAAAATTTACATAGAagtagtctaggaaggagaatgat a" /listShort="yobL, yobK, S721, S720" /listLong="yobJ, S719, S718, S716" /label="upshifts" promotor_-35 complement(1904216..1904223) /Source="Nicolas_upshift_promotors" /id="U1542" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=3217 /SigmaFactorBS="gtgtgatgtataagacagtcattttggctgtctttttcTGTT ATTCaattagattacTGTGGTAAAATTTACATAGAagtagtctaggaaggagaatgat a" /listShort="yobL, yobK, S721, S720" /listLong="yobJ, S719, S718, S716" /label="promotor_-35" CDS complement(1904263..1904820) /gene="yobM" /locus_tag="Delta6_BSU_19010_SNPvariant" /old_locus_tag="BSU_19010" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type h : extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative phage protein; putative defective prophage 6" /protein_id="NP_389782.3" /db_xref="EnsemblGenomes-Gn:BSU19010" /db_xref="EnsemblGenomes-Tr:CAB13793" /db_xref="InterPro:IPR018958" /db_xref="SubtiList:BG13505" /db_xref="UniProtKB/Swiss-Prot:O34377" /modified_by="User" /translation="MTNFVHKTVNGLKSLLDEKGAIQLFCSEGDIMEFLVTFSQDKAT LNDIQSFEAKHQLTLPQDYQKFMTLHNGAKIFEILSDGENIGGGLQLFSLEEIEEELK YEDLFEDINGIPIGYLLEECHLMIDKDKVNQGDPNYLYIFESGLEYNPLNLNFEKFLD RYILANGEPFWDWRYYTAENYYRTR*" /label="Delta6_BSU_19010_SNPvariant" gene complement(1904263..1904820) /gene="yobM" /locus_tag="Delta6_BSU_19010_SNPvariant" /old_locus_tag="BSU_19010" /modified_by="User" /label="Delta6_BSU_19010_SNPvariant" Polymorphism join(1904753,1904755) /Source="geneious" /ID="SNP_BsDelta6_2074149_2074149" /Polymorphism_Type="SNP (transversion)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change="K -> Q" /CDS_Position=67 /Change="T -> G" /Codon_Change="AAA -> CAA" /Coverage=154 /locus_tag="BSU_19010" /Protein_Effect="Substitution" /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides="G" /Variant_P_Value=0 /Variant_Raw_Frequency=154 /comment="Delta6_BSU_19010_SNPvariant" /modified_by="User" / /label="Polymorphism_Delta6" S_feature complement(1904827..1905222) /Source="Nicolas_S_feature" /locus_tag="new_2074222_2074617_c" /HighExp="M0t90, LoTm, M40t90, Lbstat, LBGstat, M9-stat, T0.30H, T2.30H, T1.0H, T2.0H" /AntisenseName="yobN" /AntisenseCor="-6.3634699133798794E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S722" promotor_-35 1904885..1904890 /Source="Nicolas_upshift_promotors" /id="U1543" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1014 /SigmaFactorBS="ctttcaaattccaaaagatgtgaacagatcGTGATAggtgct cttttcagtGAATATAATGCAATAAATTctaaaaagaggtgcctccaaaaattgaatt c" /listShort="S723, yobN, S724" /listLong="S725, yobO, S727, S728" /label="promotor_-35" promotor_-10 1904906..1904924 /Source="Nicolas_upshift_promotors" /id="U1543" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1014 /SigmaFactorBS="ctttcaaattccaaaagatgtgaacagatcGTGATAggtgct cttttcagtGAATATAATGCAATAAATTctaaaaagaggtgcctccaaaaattgaatt c" /listShort="S723, yobN, S724" /listLong="S725, yobO, S727, S728" /label="promotor_-10" upshifts 1904915 /Source="Nicolas_upshifts" /id="U1543" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1014 /SigmaFactorBS="ctttcaaattccaaaagatgtgaacagatcGTGATAggtgct cttttcagtGAATATAATGCAATAAATTctaaaaagaggtgcctccaaaaattgaatt c" /listShort="S723, yobN, S724" /listLong="S725, yobO, S727, S728" /label="upshifts" S_feature 1904917..1905043 /Source="Nicolas_S_feature" /locus_tag="new_2074312_2074438" /HighExp="S3, S4, S5, S6, M9-stat, S8, S7, T5.0H, T4.0H, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S723" CDS 1904948..1906384 /gene="yobN" /locus_tag="BSU_19020" /old_locus_tag="BSU19020" /EC_number="1.4.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative amine oxidase (flavoprotein)" /protein_id="NP_389783.2" /db_xref="EnsemblGenomes-Gn:BSU19020" /db_xref="EnsemblGenomes-Tr:CAB13794" /db_xref="GOA:O34363" /db_xref="InterPro:IPR001613" /db_xref="InterPro:IPR002937" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG13506" /db_xref="UniProtKB/Swiss-Prot:O34363" /translation="MNSLMNDDMVKIIRNGLSASQHPKHILVIGAGLSGLVSASLLKN AGHRVTILEASGRAGGRVCTLRSPFSDDLYFNAGPMRIPNNHSLTLEYIKKFKLPTNV FINRTPMDIIYANGIKTRLQVFERAPGILRYPVAPNEQGKTSEELMLSLLQPILNFIN QNPARNWRIVEEQYKNHSLSSFLNTYFSYGAIDMIGVLLDMEAYMGMSLVEVLRESIF FSSPAHFYEITGGMDLLPHAFLPQLKTNILYHQKMMKMSQGENRVTIHCQHQQTAEFT SFTADLAIVTIPFSTLRFVKVEPYHSFSYYKRRAIRELNYISATKIGIEFKSRFWEKA GQHGGKSITDLPIRFSYYPSRNIGANGHAVILASYTWADEALIWDSLSEGERIQYTLL NLSEIYGDIVWSEFVSGTSFSWSQYPYSAGGFTAFEPGQELELYPYIPVPEGRVHFAG EHASLTHAWMQGAIESGIRVAYEVNRLP*" /label="yobN CDS" gene 1904948..1906384 /gene="yobN" /locus_tag="BSU_19020" /old_locus_tag="BSU19020" /label="yobN gene" promotor_-10 complement(1905208..1905227) /Source="Nicolas_upshift_promotors" /id="U1544" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.425574425574426" /psig="0.997002997002997" /xcortree=3167 /SigmaFactorBS="atgatgtccatcggggttctgttgataaatacattTGTTGGC aatttgaatttttTGATATATTCTAAGGTTAACgaatggttattcggtatgcgcatcg g" /listShort="S722, yobM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1905222) /Source="Nicolas_upshifts" /id="U1544" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.425574425574426" /psig="0.997002997002997" /xcortree=3167 /SigmaFactorBS="atgatgtccatcggggttctgttgataaatacattTGTTGGC aatttgaatttttTGATATATTCTAAGGTTAACgaatggttattcggtatgcgcatcg g" /listShort="S722, yobM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1905241..1905247) /Source="Nicolas_upshift_promotors" /id="U1544" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.425574425574426" /psig="0.997002997002997" /xcortree=3167 /SigmaFactorBS="atgatgtccatcggggttctgttgataaatacattTGTTGGC aatttgaatttttTGATATATTCTAAGGTTAACgaatggttattcggtatgcgcatcg g" /listShort="S722, yobM" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1906385..1906716 /Source="Nicolas_S_feature" /locus_tag="new_2075780_2076111" /HighExp="S3, S8, S4, S5, S7, M9-stat, S6, T5.0H, C30, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S724" promotor_-35 1906698..1906706 /Source="Nicolas_upshift_promotors" /id="U1545" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=526 /SigmaFactorBS="tttcattgacttacatttcttgaaaaccagtataaatcctAA AGGAATTttgtaacaaaTACAGAATTGGAAAGAGAAgcgccaaaagaaatgctaactc c" /listShort="S725, yobO, S727, S728" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1906717..1906735 /Source="Nicolas_upshift_promotors" /id="U1545" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=526 /SigmaFactorBS="tttcattgacttacatttcttgaaaaccagtataaatcctAA AGGAATTttgtaacaaaTACAGAATTGGAAAGAGAAgcgccaaaagaaatgctaactc c" /listShort="S725, yobO, S727, S728" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1906718..1906810 /Source="Nicolas_S_feature" /locus_tag="new_2076113_2076205" /HighExp="M9-stat, T1.30H, T2.0H, S2, T2.30H, Lbstat, BC, T0.30H, T3.30H, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH" /TUshortPSig=1 /TUlongSig="SigEF" /TUlongPSig="0.995" /label="S725" upshifts 1906718 /Source="Nicolas_upshifts" /id="U1545" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=526 /SigmaFactorBS="tttcattgacttacatttcttgaaaaccagtataaatcctAA AGGAATTttgtaacaaaTACAGAATTGGAAAGAGAAgcgccaaaagaaatgctaactc c" /listShort="S725, yobO, S727, S728" /GFF_Attribute="listLong" /label="upshifts" CDS 1906811..1909231 /gene="yobO" /locus_tag="BSU_19030" /old_locus_tag="BSU19030" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11562162, 19450535; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative phage-related pre-neck appendage protein; defective prophage 6" /protein_id="NP_389784.1" /db_xref="EnsemblGenomes-Gn:BSU19030" /db_xref="EnsemblGenomes-Tr:CAB13795" /db_xref="InterPro:IPR006626" /db_xref="InterPro:IPR011050" /db_xref="InterPro:IPR012334" /db_xref="InterPro:IPR021865" /db_xref="InterPro:IPR024535" /db_xref="SubtiList:BG13507" /db_xref="UniProtKB/Swiss-Prot:O34433" /translation="MVHFKNCPDPSLNANSQSHPEFSSELEHIKTRMQNFIKHSVTDQ NIEVTDARVTAEGEVTSLLKERLDKEYYRLLSKITREVNVADFGAVPDGRDNTEAFRK AIGNGRVKVHVPAGEYLVQGIKLPSWTTIVGQGKGITVIKLHEDTPAHEWVITNDDYQ NGNRNIFVQGMSLDWNPSRQCGVRNPGGQFSSCLTFAKVEYGWIKDVEAINAGLHGID ITSPTYDHLPDTDWTKDGSRYIWIDNCVTYGSGDDGITTHYSEYIFISNCHSGNPRGT EFAEGVSNSNGIEIDDGSRHVWLLNNFTSGNIRGVEVKAHELWPASQNVHIIGHISYR DVRAFDLRHIGHHQITDPESTTAYDVTLIDCSAVEPVFNSLYDAVTPRALVISAYKNV NVSGFTAIGDPDYDYKENPVVALQYRSQNITINGIKIRGFKKAGVDINLSGGSNKTDY IKISNFDIYKSAPKGISIGGGLYNVNILNGTMITDNGTVAIQSPNNQATILGVQSEGY SVAASIKGQTYQQVPINLKGGIQLATTSGFAVNQTSAVIAGTGDITARGERNAVISSS GGSSTEGSRALIASSNNAHIRGNQASRTILSSENIILEEPYTVAGGHQSIKWLLDSVR GNGTFAGAISSSLGGYGEYFESSTGQLIHTGTIVTLRGEKIVPANVGDYMLGVISETS AFISGASSFVWQGRYLTNEFGGFIYETVTDEESGELIRVPKQNPDYDTALEANYHSRA ARDEWHVVGLVGQHYVRIDETVNQGDYLTAHNGIGTKATEGSWKVMKITSAYTSEKGY GIALTVIK*" /label="yobO CDS" gene 1906811..1909231 /gene="yobO" /locus_tag="BSU_19030" /old_locus_tag="BSU19030" /label="yobO gene" S_feature complement(1909153..1909788) /Source="Nicolas_S_feature" /locus_tag="new_2078548_2079183_c" /HighExp="MG 150, S8, MG 120, S7, MG 90, GM-0.1, Glu, Fru, GM-0.2, GM 5" /AntisenseName="yobO" /AntisenseCor="0.134597835896198" /AntisenseRegPval="-1.6" /CDS_PredictionProba="0.40121099999999998" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S726" S_feature 1909232..1909689 /Source="Nicolas_S_feature" /locus_tag="new_2078627_2079084" /HighExp="M9-stat, Lbstat, BC, T1.30H, S2, T0.30H, T2.0H, T3.0H, T2.30H, S4" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH" /TUshortPSig=1 /TUlongSig="SigEF" /TUlongPSig="0.995" /label="S727" promotor_-35 1909664..1909671 /Source="Nicolas_upshift_promotors" /id="U1546" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.488511488511489" /psig="0.896103896103896" /xcortree=87 /SigmaFactorBS="tctaaattcatttcaccgttactaaaagtaatcCTTGCATTc cttcgccctcCATGCTATATTCATATAGCGatgagctgaattgtgtaagccgatgtac a" /listShort="S728" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1909683..1909702 /Source="Nicolas_upshift_promotors" /id="U1546" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.488511488511489" /psig="0.896103896103896" /xcortree=87 /SigmaFactorBS="tctaaattcatttcaccgttactaaaagtaatcCTTGCATTc cttcgccctcCATGCTATATTCATATAGCGatgagctgaattgtgtaagccgatgtac a" /listShort="S728" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1909691..1909801 /Source="Nicolas_S_feature" /locus_tag="new_2079086_2079196" /HighExp="LoTm, S7, HPh, LPhT, S8, BT, S6, G/S, S0, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH" /TUshortPSig="0.896, 1" /TUlongSig="SigEF" /TUlongPSig="0.995" /label="S728" upshifts 1909691 /Source="Nicolas_upshifts" /id="U1546" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.488511488511489" /psig="0.896103896103896" /xcortree=87 /SigmaFactorBS="tctaaattcatttcaccgttactaaaagtaatcCTTGCATTc cttcgccctcCATGCTATATTCATATAGCGatgagctgaattgtgtaagccgatgtac a" /listShort="S728" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 1909701..1909808 /gene="bsrF" /locus_tag="BSU_misc_RNA_75" /product="small untranslated regulatory RNA" /experiment="publication(s) with functional evidences, PMID:18948176, 19542274" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18948176, 19542274; Product type n: RNA" /label="bsrF RNA" gene 1909701..1909808 /gene="bsrF" /locus_tag="BSU_misc_RNA_75" /label="bsrF gene" downshifts 1909786 /Source="Nicolas_upshifts" /id="D1044" /incds=0 /nref=65 /ntot=254 /MaxReadThrough="1.60135" /MaxDrop="9.06442" /score="30.7999406" /energy="-13.9" /TU="NA" /idTUdmin="U1545" /TUdmin=7 /isTUend="TRUE" /label="downshifts" CDS complement(1909819..1910151) /gene="csaA" /locus_tag="BSU_19040" /old_locus_tag="BSU19040" /function="16.1: Circulate" /function="16.6: Maintain" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10658654, 10816431, 13129613, 15856219, 17372352, 28724440; Product type f : factor" /codon_start=1 /transl_table=11 /product="molecular chaperone for secreting proteins" /protein_id="NP_389785.1" /db_xref="EnsemblGenomes-Gn:BSU19040" /db_xref="EnsemblGenomes-Tr:CAB13796" /db_xref="GOA:P37584" /db_xref="InterPro:IPR002547" /db_xref="InterPro:IPR008231" /db_xref="InterPro:IPR012340" /db_xref="PDB:2NZH" /db_xref="PDB:2NZO" /db_xref="SubtiList:BG10809" /db_xref="UniProtKB/Swiss-Prot:P37584" /translation="MAVIDDFEKLDIRTGTIVKAEEFPEARVPAIKLVIDFGTEIGIK QSSAQITKRYKPEGLINKQVIAVVNFPPRRIAGFKSEVLVLGGIPGQGDVVLLQPDQP VPNGTKIG*" /label="csaA CDS" gene complement(1909819..1910151) /gene="csaA" /locus_tag="BSU_19040" /old_locus_tag="BSU19040" /label="csaA gene" downshifts complement(1909833) /Source="Nicolas_upshifts" /id="D1045" /incds=0 /nref=28 /ntot=228 /MaxReadThrough="4.42209" /MaxDrop="5.706" /score="-8.98970984" /energy="-13.9" /TU="U1547" /idTUdmin="U1550" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1910216..1910941) /gene="yobQ" /locus_tag="BSU_19050" /old_locus_tag="BSU19050" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10704478, 27038276; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (AraC/XylS family)" /protein_id="NP_389786.1" /db_xref="EnsemblGenomes-Gn:BSU19050" /db_xref="EnsemblGenomes-Tr:CAB13797" /db_xref="GOA:O34901" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR013096" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR018060" /db_xref="InterPro:IPR018062" /db_xref="SubtiList:BG13508" /db_xref="UniProtKB/Swiss-Prot:O34901" /translation="MLMDSLQEIICEKRTYTRLYHSHKHAYSQFLFPLEGSIDLETEG RQVKLNPDHFLYIPPQCEHRFRSIGRNECLVLDVPLHAMKIDEYRAGSGIEAALDPFW SSIRYLLTEEAKAGTANSLHMLVQYIKEKLQSHSYASIAYIHSHLFERLTIKKLAEIE HYHPAYYSSWFKKQTGKSPQNYIADLRLEEAKRMLMERNETLTVVSEALGFQNLSSFT RWFTKSTGMPPRLYRNTLYSDKK*" /label="yobQ CDS" gene complement(1910216..1910941) /gene="yobQ" /locus_tag="BSU_19050" /old_locus_tag="BSU19050" /label="yobQ gene" CDS complement(1910956..1911699) /gene="yobR" /locus_tag="BSU_19060" /old_locus_tag="BSU19060" /EC_number="2.3.1.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12793527, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_389787.1" /db_xref="EnsemblGenomes-Gn:BSU19060" /db_xref="EnsemblGenomes-Tr:CAB13798" /db_xref="GOA:O34376" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13509" /db_xref="UniProtKB/Swiss-Prot:O34376" /translation="MDDIRKIERLAAASWPAYFQKSIGKWLLRANFGVTKRANSVWTS ADMPEGDFQLEAELFYQSLGLPVCFHISNASPKGLDDALADSRYEKVDECFQMTALCR SIMSRTNDNSRFTYKWEQEPSSVWIDEFIQLEGFSPERHKGYKHIFERMPPCKTFFKM YDKESLTALGTVSVIDGYGGLSNIVVAEEHRGKGAGTQVIRVLTEWAKNNGAERMFLQ VMKENLAAVSLYGKIGFSPISEHHYRIKR*" /label="yobR CDS" gene complement(1910956..1911699) /gene="yobR" /locus_tag="BSU_19060" /old_locus_tag="BSU19060" /label="yobR gene" promotor_-10 complement(1911727..1911746) /Source="Nicolas_upshift_promotors" /id="U1547" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.273726273726274" /psig="0.997002997002997" /xcortree=3044 /SigmaFactorBS="ttattaataaacaataaaaatattatgtaaacaaataaatGG ATGTCttatatttctgaaTATTGTATAATATCAAGGGAgtatacataggggagaggca t" /listShort="yobR, yobQ, csaA, S726" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1911746) /Source="Nicolas_upshifts" /id="U1547" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.273726273726274" /psig="0.997002997002997" /xcortree=3044 /SigmaFactorBS="ttattaataaacaataaaaatattatgtaaacaaataaatGG ATGTCttatatttctgaaTATTGTATAATATCAAGGGAgtatacataggggagaggca t" /listShort="yobR, yobQ, csaA, S726" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1911760..1911766) /Source="Nicolas_upshift_promotors" /id="U1547" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.273726273726274" /psig="0.997002997002997" /xcortree=3044 /SigmaFactorBS="ttattaataaacaataaaaatattatgtaaacaaataaatGG ATGTCttatatttctgaaTATTGTATAATATCAAGGGAgtatacataggggagaggca t" /listShort="yobR, yobQ, csaA, S726" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1911777..1912352) /gene="yobS" /locus_tag="BSU_19070" /old_locus_tag="BSU19070" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_389788.1" /db_xref="EnsemblGenomes-Gn:BSU19070" /db_xref="EnsemblGenomes-Tr:CAB13799" /db_xref="GOA:O34892" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR025996" /db_xref="InterPro:IPR036271" /db_xref="SubtiList:BG13510" /db_xref="UniProtKB/Swiss-Prot:O34892" /translation="MSPRIGLTQKMIVDAAAEIADQEGVNGVSLAALSKKMNVRPPSL YNHINGLQAIRAELAVRGLTKLFDQMADSVTERKGDSAMLSLAHAYVDFAIENPGYYE AALLKVHDKRTEIVSDQIVCLVTKLLIENGYASEKTAIHATRGLRSLLHGFTVLIAKE AFEREEDILESLSFSIRTFLSGLLINNKNIM*" /label="yobS CDS" gene complement(1911777..1912352) /gene="yobS" /locus_tag="BSU_19070" /old_locus_tag="BSU19070" /label="yobS gene" CDS complement(1912358..1913059) /gene="yobT" /locus_tag="BSU_19080" /old_locus_tag="BSU19080" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent hydrolase" /protein_id="NP_389789.1" /db_xref="EnsemblGenomes-Gn:BSU19080" /db_xref="EnsemblGenomes-Tr:CAB13800" /db_xref="GOA:O34910" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG13511" /db_xref="UniProtKB/Swiss-Prot:O34910" /translation="MRITQYQTVWQLTFFPALFPVNCYLVEEENEVTLIDAALPGSYK GIIQAVNQLGKPLQHILLTHAHGDHVGSLDTLAQTFPHAKVMISERDSFLLQGDTSLR QDEPQTPIKGGIPKHIQTKPHQLLTGGETIGSLLAIPTPGHTPGSMSFLDTRNGTLIA GDAFQLRGGIAVSGQIKWAFPFPAFATWNKEEAIKSAQLLADKAPSCLAVGHGKFLRS PSERMRQAIQKAKKG*" /label="yobT CDS" gene complement(1912358..1913059) /gene="yobT" /locus_tag="BSU_19080" /old_locus_tag="BSU19080" /label="yobT gene" promotor_-10 complement(1913089..1913108) /Source="Nicolas_upshift_promotors" /id="U1548" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.896103896103896" /psig=1 /xcortree=2198 /SigmaFactorBS="cgataaaaaaataataaacTCTTGAAAaactaatggtgttaG TTAATAATAAAACTAACACcattagtttttgttaggaggaataaaaagatgagaatta c" /listShort="yobT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1913089) /Source="Nicolas_upshifts" /id="U1548" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.896103896103896" /psig=1 /xcortree=2198 /SigmaFactorBS="cgataaaaaaataataaacTCTTGAAAaactaatggtgttaG TTAATAATAAAACTAACACcattagtttttgttaggaggaataaaaagatgagaatta c" /listShort="yobT" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1913093..1913108) /Source="Nicolas_upshift_promotors" /id="U1549" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=2199 /SigmaFactorBS="aaatgccgcagtgccacagcgagcacaagttaacatttatgt agcgataaaaaaataataaacTCTTGAAAaactaatggtgttaGTTAATAATAAAACT A" /listShort="yobT" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1913123..1913130) /Source="Nicolas_upshift_promotors" /id="U1548" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.896103896103896" /psig=1 /xcortree=2198 /SigmaFactorBS="cgataaaaaaataataaacTCTTGAAAaactaatggtgttaG TTAATAATAAAACTAACACcattagtttttgttaggaggaataaaaagatgagaatta c" /listShort="yobT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(1913123..1913130) /Source="Nicolas_upshift_promotors" /id="U1549" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=2199 /SigmaFactorBS="aaatgccgcagtgccacagcgagcacaagttaacatttatgt agcgataaaaaaataataaacTCTTGAAAaactaatggtgttaGTTAATAATAAAACT A" /listShort="yobT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(1913133) /Source="Nicolas_upshifts" /id="U1549" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig="0.998001998001998" /xcortree=2199 /SigmaFactorBS="aaatgccgcagtgccacagcgagcacaagttaacatttatgt agcgataaaaaaataataaacTCTTGAAAaactaatggtgttaGTTAATAATAAAACT A" /listShort="yobT" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1913136..1913618) /gene="yobU" /locus_tag="BSU_19090" /old_locus_tag="BSU19090" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative effector of transcriptional regulator" /protein_id="NP_389790.1" /db_xref="EnsemblGenomes-Gn:BSU19090" /db_xref="EnsemblGenomes-Tr:CAB13801" /db_xref="InterPro:IPR010499" /db_xref="InterPro:IPR011256" /db_xref="InterPro:IPR029442" /db_xref="SubtiList:BG13512" /db_xref="UniProtKB/Swiss-Prot:O34637" /translation="MGFSHITHLDLKRFAGLSQRTSNALEMTEERRIPALWDQLWKQD MSALLSQAEKDKSIIALYSNYEQETNGFYTFSVGTFQEYDDILPGPYENIDLPASAYA VFTSRIGPIEEIVLETWKEIWTWDKRHLRTFTGDFEMYDQNAAVPQRAQVNIYVAIKK *" /label="yobU CDS" gene complement(1913136..1913618) /gene="yobU" /locus_tag="BSU_19090" /old_locus_tag="BSU19090" /label="yobU gene" misc_feature complement(1913657..1913674) /Source="Nicolas_upshift_promotors" /id="U1550" /multdbtbs="-" /comp="M18" /sig="Sig-" /pcomp="0.334665334665335" /psig="0.334665334665335" /xcortree=1509 /SigmaFactorBS="ataaagtaaaagaaaccattcatcacatgcaaaaaatatatg aaaccTGACACACTGCTGTCAGGtttctttgtctataatcttaaaaaaaggaggagat c" /listShort="yobU, yobT, yobS, yobR, yobQ, csaA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1913661) /Source="Nicolas_upshifts" /id="U1550" /multdbtbs="-" /comp="M18" /sig="Sig-" /pcomp="0.334665334665335" /psig="0.334665334665335" /xcortree=1509 /SigmaFactorBS="ataaagtaaaagaaaccattcatcacatgcaaaaaatatatg aaaccTGACACACTGCTGTCAGGtttctttgtctataatcttaaaaaaaggaggagat c" /listShort="yobU, yobT, yobS, yobR, yobQ, csaA" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1913672..1914613) /gene="yobV" /locus_tag="BSU_19100" /old_locus_tag="BSU19100" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_389791.1" /db_xref="EnsemblGenomes-Gn:BSU19100" /db_xref="EnsemblGenomes-Tr:CAB13802" /db_xref="GOA:O34920" /db_xref="InterPro:IPR001034" /db_xref="InterPro:IPR013196" /db_xref="InterPro:IPR026881" /db_xref="InterPro:IPR028349" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13513" /db_xref="UniProtKB/Swiss-Prot:O34920" /translation="MKLERLLAMVVLLISKKQVQAAELAELFEVSVRTIYRDIETINR AGIPIVTSQGSGGGIGIMETYRLEREWLKEEELFAIASALQSVSSMYEPVSHSTAYQK IKHLIPEQSTQAFKHQTEKWFIDMTAWGHTEDQKTLREKISAAIDRLLTISFTYTSAS GETLLRETEPYTLVCKAGHWYLYAYCLVRNDFRFFKLNRMKDLAILHQTFIRKDIQLD TLPWDKSWYQKDRLTELVILVQPSARQRIGEWFGYDVLHCCEEDEICQAVISLPEDQW LIGFLLQFGKDIEVLQPLHIRDKVKETIHHMQKIYET*" /label="yobV CDS" gene complement(1913672..1914613) /gene="yobV" /locus_tag="BSU_19100" /old_locus_tag="BSU19100" /label="yobV gene" downshifts complement(1913705) /Source="Nicolas_upshifts" /id="D1046" /incds=0 /nref=4 /ntot=33 /MaxReadThrough="0.95712" /MaxDrop="3.62763" /score="-3.71616684" /energy="-9" /TU="NA" /idTUdmin="U1548" /TUdmin="-770" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1914643..1914662) /Source="Nicolas_upshift_promotors" /id="U1551" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.615384615384615" /psig="0.971028971028971" /xcortree=3116 /SigmaFactorBS="tatgcgaggtgtattccgccgcataatagatATGCCcaagct ttatcaaAATGTTATGATTGTTTTGTTggaaaatacaagaagaaaaggtgcgcagaat g" /listShort="yobV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1914651) /Source="Nicolas_upshifts" /id="U1551" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.615384615384615" /psig="0.971028971028971" /xcortree=3116 /SigmaFactorBS="tatgcgaggtgtattccgccgcataatagatATGCCcaagct ttatcaaAATGTTATGATTGTTTTGTTggaaaatacaagaagaaaaggtgcgcagaat g" /listShort="yobV" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1914676..1914680) /Source="Nicolas_upshift_promotors" /id="U1551" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.615384615384615" /psig="0.971028971028971" /xcortree=3116 /SigmaFactorBS="tatgcgaggtgtattccgccgcataatagatATGCCcaagct ttatcaaAATGTTATGATTGTTTTGTTggaaaatacaagaagaaaaggtgcgcagaat g" /listShort="yobV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1914684..1914693 /Source="Nicolas_upshift_promotors" /id="U1552" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1341 /SigmaFactorBS="cataacattttgataaagcttgggcatatcTATTATGCGGcg gaatacacctCGCATATGCTATGAAAACAGgggtttccccttcttttttgtgttcagt a" /listShort="S729, yobW" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1914706..1914725 /Source="Nicolas_upshift_promotors" /id="U1552" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1341 /SigmaFactorBS="cataacattttgataaagcttgggcatatcTATTATGCGGcg gaatacacctCGCATATGCTATGAAAACAGgggtttccccttcttttttgtgttcagt a" /listShort="S729, yobW" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1914714 /Source="Nicolas_upshifts" /id="U1552" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1341 /SigmaFactorBS="cataacattttgataaagcttgggcatatcTATTATGCGGcg gaatacacctCGCATATGCTATGAAAACAGgggtttccccttcttttttgtgttcagt a" /listShort="S729, yobW" /GFF_Attribute="listLong" /label="upshifts" S_feature 1914729..1914793 /Source="Nicolas_S_feature" /locus_tag="new_2084124_2084188" /HighExp="BT, S7, B36, S8, S6, Pyr, G/S, B60, Glucon, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S729" promotor_-35 1914765..1914770 /Source="Nicolas_upshift_promotors" /id="U1553" /multdbtbs="SigK" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1008 /SigmaFactorBS="cttcttttttgtgttcagtatttatttcagCTACTAtttccg accggataaGCATACACTTCTCAACGGAggggatttcacatcatgcatcttacacttc a" /listShort="yobW" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1914786..1914804 /Source="Nicolas_upshift_promotors" /id="U1553" /multdbtbs="SigK" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1008 /SigmaFactorBS="cttcttttttgtgttcagtatttatttcagCTACTAtttccg accggataaGCATACACTTCTCAACGGAggggatttcacatcatgcatcttacacttc a" /listShort="yobW" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1914795 /Source="Nicolas_upshifts" /id="U1553" /multdbtbs="SigK" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1008 /SigmaFactorBS="cttcttttttgtgttcagtatttatttcagCTACTAtttccg accggataaGCATACACTTCTCAACGGAggggatttcacatcatgcatcttacacttc a" /listShort="yobW" /GFF_Attribute="listLong" /label="upshifts" CDS 1914819..1915364 /gene="yobW" /locus_tag="BSU_19110" /old_locus_tag="BSU19110" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:8990290, 11717295, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8990290, 11717295, 15849754, 16850406; Product type f: factor" /codon_start=1 /transl_table=11 /product="mother cell-specific membrane sporulation protein" /protein_id="NP_389792.1" /db_xref="EnsemblGenomes-Gn:BSU19110" /db_xref="EnsemblGenomes-Tr:CAB13803" /db_xref="GOA:P94497" /db_xref="InterPro:IPR014743" /db_xref="SubtiList:BG12269" /db_xref="UniProtKB/Swiss-Prot:P94497" /translation="MHLTLQSVYPAIIIIFFLYKKIKRSIGYQPLKPRWLFTRIILFS LFAFGLSIFSAIHPFLYGYLILGILGGWLLVFFAKKNISFEKRRGKIYFRTHIWVEVI LLTLFLSRFLYRVTELYLTSPDLNRLGSYSQSIGTDPLTIGVCFLIAVYYIGFSSFII KLSRNELEQHEYNKEKDILAR*" /label="yobW CDS" gene 1914819..1915364 /gene="yobW" /locus_tag="BSU_19110" /old_locus_tag="BSU19110" /label="yobW gene" downshifts 1915323 /Source="Nicolas_upshifts" /id="D1047" /incds=0 /nref=20 /ntot=63 /MaxReadThrough="3.56215" /MaxDrop="4.5413" /score="-4.21976438" /energy="-17.7" /TU="U1552,U1553" /idTUdmin="U1552" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" CDS complement(1915391..1915714) /gene="czrA" /locus_tag="BSU_19120" /old_locus_tag="BSU19120" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15948947, 16406068, 16430705, 19170879, 19995076, 25213752" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15948947, 16406068, 16430705, 19170879, 19995076, 25213752; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (multiple metal-sensing ArsR-SmtB transcriptional repressor favouring Zn2+)" /protein_id="NP_389793.1" /db_xref="EnsemblGenomes-Gn:BSU19120" /db_xref="EnsemblGenomes-Tr:CAB13804" /db_xref="GOA:O31844" /db_xref="InterPro:IPR001845" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13748" /db_xref="UniProtKB/Swiss-Prot:O31844" /translation="MTEFRETEQSAADLDEETLFLVAQTFKALSDPTRIRILHLLSQG EHAVNGIAEKLNLLQSTVSHQLRFLKNLRLVKSRREGTSIYYSPEDEHVLDVLQQMIH HTQHD*" /label="czrA CDS" gene complement(1915391..1915714) /gene="czrA" /locus_tag="BSU_19120" /old_locus_tag="BSU19120" /label="czrA gene" downshifts complement(1915398) /Source="Nicolas_upshifts" /id="D1048" /incds=0 /nref=73 /ntot=252 /MaxReadThrough="1.89304" /MaxDrop="4.873" /score="17.3750937" /energy="-18.6" /TU="NA" /idTUdmin="U1554" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1915735..1915754) /Source="Nicolas_upshift_promotors" /id="U1554" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.462537462537463" /psig="0.999000999001" /xcortree=2223 /SigmaFactorBS="actatgagattgaaatggaatacaagcaggctGGTTTGCAct caagcgcattTGTTATAAGATAAAACTATGaataaagaaaggtgatacatatgactga a" /listShort="czrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1915746) /Source="Nicolas_upshifts" /id="U1554" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.462537462537463" /psig="0.999000999001" /xcortree=2223 /SigmaFactorBS="actatgagattgaaatggaatacaagcaggctGGTTTGCAct caagcgcattTGTTATAAGATAAAACTATGaataaagaaaggtgatacatatgactga a" /listShort="czrA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1915767..1915774) /Source="Nicolas_upshift_promotors" /id="U1554" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.462537462537463" /psig="0.999000999001" /xcortree=2223 /SigmaFactorBS="actatgagattgaaatggaatacaagcaggctGGTTTGCAct caagcgcattTGTTATAAGATAAAACTATGaataaagaaaggtgatacatatgactga a" /listShort="czrA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1915835..1915841 /Source="Nicolas_upshift_promotors" /id="U1555" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.444555444555445" /psig="0.994005994005994" /xcortree=3129 /SigmaFactorBS="tttcaatctcatagtttaaatttatgtttcaaatcaggtttt tACTTGGTctgatataccctctTATGTCATAATAAAAAAGGTcatactgctccaaaca t" /listShort="yocA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1915852 /Source="Nicolas_upshifts" /id="U1555" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.444555444555445" /psig="0.994005994005994" /xcortree=3129 /SigmaFactorBS="tttcaatctcatagtttaaatttatgtttcaaatcaggtttt tACTTGGTctgatataccctctTATGTCATAATAAAAAAGGTcatactgctccaaaca t" /listShort="yocA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1915856..1915875 /Source="Nicolas_upshift_promotors" /id="U1555" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.444555444555445" /psig="0.994005994005994" /xcortree=3129 /SigmaFactorBS="tttcaatctcatagtttaaatttatgtttcaaatcaggtttt tACTTGGTctgatataccctctTATGTCATAATAAAAAAGGTcatactgctccaaaca t" /listShort="yocA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1915908..1916585 /gene="yocA" /locus_tag="BSU_19130" /old_locus_tag="BSU19130" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14563871, 20400549; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative murein fragments glycosidase" /protein_id="NP_389794.1" /db_xref="EnsemblGenomes-Gn:BSU19130" /db_xref="EnsemblGenomes-Tr:CAB13805" /db_xref="GOA:O34636" /db_xref="InterPro:IPR023346" /db_xref="SubtiList:BG13514" /db_xref="UniProtKB/Swiss-Prot:O34636" /translation="MKKKRKGCFAAAGFMMIFVFVIASFLLVLLFFNRDLIKKLPIDT KTIVLERLTDYKPLVEEELESQGLSNYTSLILGMMYQESKGKGNDPMQSSESLGLKRN EITDPQLSVKQGIKQFTLMYKTGKEKGVDLDTIIQSYNMGAGYIDFVAEHGGTHTEEL AKQYSEQQVKKNPDLYTCGGNAKNFRYPYCYGDYTYAEKVKEKTKTVEESLQVATLET MESKAHE*" /label="yocA CDS" gene 1915908..1916585 /gene="yocA" /locus_tag="BSU_19130" /old_locus_tag="BSU19130" /label="yocA gene" downshifts 1916577 /Source="Nicolas_upshifts" /id="D1049" /incds=0 /nref=207 /ntot=268 /MaxReadThrough="3.9729" /MaxDrop="8.52704" /score="-4.21976438" /energy="-17.7" /TU="U1555" /idTUdmin="U1555" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" CDS complement(1916675..1917211) /gene="yozB" /locus_tag="BSU_19140" /old_locus_tag="BSU19140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 19222757, 24214949; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_389795.1" /db_xref="EnsemblGenomes-Gn:BSU19140" /db_xref="EnsemblGenomes-Tr:CAB13806" /db_xref="GOA:O31845" /db_xref="InterPro:IPR007352" /db_xref="InterPro:IPR013833" /db_xref="SubtiList:BG13749" /db_xref="UniProtKB/Swiss-Prot:O31845" /translation="MNQTENKPKNYTGIVLTLTVLINGLIAVLFFMPKLDQFSHANIH ILPMLNAIFNSFTFIFLLAALIMIKQKNIKAHKRFILAAFTTTLLFLICYVTYHSIAE NTLYGGEGIMRPIYFFILITHICLSAIIVPLALFTLIRGFSMQVERHKKIARWTMPLW LYVSLTGVIVYLMISPYY*" /label="yozB CDS" gene complement(1916675..1917211) /gene="yozB" /locus_tag="BSU_19140" /old_locus_tag="BSU19140" /label="yozB gene" downshifts complement(1916698) /Source="Nicolas_upshifts" /id="D1050" /incds=0 /nref=175 /ntot=250 /MaxReadThrough="4.33842" /MaxDrop="7.96098" /score="14.7470642" /energy="-7.7" /TU="U1556" /idTUdmin="U1557" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1917238..1917257) /Source="Nicolas_upshift_promotors" /id="U1556" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.824175824175824" /psig="0.99000999000999" /xcortree=1607 /SigmaFactorBS="gcctttgaagtgtgtctaatttctgacgaagcaatcgaaaCC GTTGACatcttctttgaatTTGCATACGATTTGGATAGCcagtacaaattaggagagg t" /listShort="yozB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1917258) /Source="Nicolas_upshifts" /id="U1556" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.824175824175824" /psig="0.99000999000999" /xcortree=1607 /SigmaFactorBS="gcctttgaagtgtgtctaatttctgacgaagcaatcgaaaCC GTTGACatcttctttgaatTTGCATACGATTTGGATAGCcagtacaaattaggagagg t" /listShort="yozB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1917271..1917278) /Source="Nicolas_upshift_promotors" /id="U1556" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.824175824175824" /psig="0.99000999000999" /xcortree=1607 /SigmaFactorBS="gcctttgaagtgtgtctaatttctgacgaagcaatcgaaaCC GTTGACatcttctttgaatTTGCATACGATTTGGATAGCcagtacaaattaggagagg t" /listShort="yozB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1917348..1918130) /gene="yocB" /locus_tag="BSU_19150" /old_locus_tag="BSU19150" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11717291, 16291680" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389796.1" /db_xref="EnsemblGenomes-Gn:BSU19150" /db_xref="EnsemblGenomes-Tr:CAB13807" /db_xref="SubtiList:BG13515" /db_xref="UniProtKB/Swiss-Prot:O34516" /translation="MAIDSLINKLQYVQLEPPDKILSLYLNTDMRDPEQQGGEWKIAL KSGFSRLKEYLAASDPEEEKCLDGIRAKMNQYLNAMGKDMPRSLVFFVSDSGIWEPIK LQVPVDTRFYWEETAVLDQLKGLRQTYPSTAFILTQQHEVKIIETVLGKIEAVERYEY DMINESWKNSHSAVDKAPPFEENRMREHVTENQSRLYKRLAASLDQKAAAKRWERMVI AGDKETADILDQHMNKPIHSKIQKNLLNENEHKVIEHLIKEA*" /label="yocB CDS" gene complement(1917348..1918130) /gene="yocB" /locus_tag="BSU_19150" /old_locus_tag="BSU19150" /label="yocB gene" downshifts complement(1917357) /Source="Nicolas_upshifts" /id="D1051" /incds=0 /nref=3 /ntot=38 /MaxReadThrough="5.37496" /MaxDrop="4.00348" /score="14.7470642" /energy="-7.7" /TU="U1557" /idTUdmin="U1557" /TUdmin="-660" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1918152..1918170) /Source="Nicolas_upshift_promotors" /id="U1557" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=229 /SigmaFactorBS="aaacaacaattccattattactagaaattagcggaaagtcaG GTTTGAtcgtttttaagagAGGAAAAAGAAAACTAACCtgtgaaaaaggaggaatcgg a" /listShort="yocB, yozB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1918171) /Source="Nicolas_upshifts" /id="U1557" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=229 /SigmaFactorBS="aaacaacaattccattattactagaaattagcggaaagtcaG GTTTGAtcgtttttaagagAGGAAAAAGAAAACTAACCtgtgaaaaaggaggaatcgg a" /listShort="yocB, yozB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1918184..1918190) /Source="Nicolas_upshift_promotors" /id="U1557" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=229 /SigmaFactorBS="aaacaacaattccattattactagaaattagcggaaagtcaG GTTTGAtcgtttttaagagAGGAAAAAGAAAACTAACCtgtgaaaaaggaggaatcgg a" /listShort="yocB, yozB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1918227..1918234 /Source="Nicolas_upshift_promotors" /id="U1558" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig=1 /xcortree=2435 /SigmaFactorBS="actttccgctaatttctagtaataatggaattgtTGTTTACA atacgcctctcttcTAATACAATTGGTAACTGTGtttctaagctgttttttgaaagga g" /listShort="yocC, yocD" /listLong="des, S730, desK, desR" /label="promotor_-35" promotor_-10 1918249..1918268 /Source="Nicolas_upshift_promotors" /id="U1558" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig=1 /xcortree=2435 /SigmaFactorBS="actttccgctaatttctagtaataatggaattgtTGTTTACA atacgcctctcttcTAATACAATTGGTAACTGTGtttctaagctgttttttgaaagga g" /listShort="yocC, yocD" /listLong="des, S730, desK, desR" /label="promotor_-10" upshifts 1918253 /Source="Nicolas_upshifts" /id="U1558" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig=1 /xcortree=2435 /SigmaFactorBS="actttccgctaatttctagtaataatggaattgtTGTTTACA atacgcctctcttcTAATACAATTGGTAACTGTGtttctaagctgttttttgaaagga g" /listShort="yocC, yocD" /listLong="des, S730, desK, desR" /label="upshifts" CDS 1918301..1918798 /gene="yocC" /locus_tag="BSU_19160" /old_locus_tag="BSU19160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 14563871" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389797.1" /db_xref="EnsemblGenomes-Gn:BSU19160" /db_xref="EnsemblGenomes-Tr:CAB13808" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13516" /db_xref="UniProtKB/Swiss-Prot:O35042" /translation="MFTVKEKNRQELEEELNDLEFQIYRMQENMKDLSKDAKVLGIDQ SKHDEWMIVSSIDDGQTCKIMLTDCKTAYRGKGCFSLVASYKDDAIHIGDIKGPPNHG FGSICMKYLKDIARDHNIPKVTGDIAKRDWNHVDRLIHFYEKHHFKVCIDHDTQSGSI KWVDL*" /label="yocC CDS" gene 1918301..1918798 /gene="yocC" /locus_tag="BSU_19160" /old_locus_tag="BSU19160" /label="yocC gene" promotor_-35 1918805..1918808 /Source="Nicolas_upshift_promotors" /id="U1559" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.314685314685315" /psig="0.984015984015984" /xcortree=3013 /SigmaFactorBS="caatccggcagcattaagtgggttgatttgtaaaaaagtCTG GaagaaagagccaagaTATGCTGTAATGGTATAAAAccattgatggagggttctatgt a" /listShort="yocD" /listLong="des, S730, desK, desR" /label="promotor_-35" promotor_-10 1918824..1918843 /Source="Nicolas_upshift_promotors" /id="U1559" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.314685314685315" /psig="0.984015984015984" /xcortree=3013 /SigmaFactorBS="caatccggcagcattaagtgggttgatttgtaaaaaagtCTG GaagaaagagccaagaTATGCTGTAATGGTATAAAAccattgatggagggttctatgt a" /listShort="yocD" /listLong="des, S730, desK, desR" /label="promotor_-10" upshifts 1918826 /Source="Nicolas_upshifts" /id="U1559" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.314685314685315" /psig="0.984015984015984" /xcortree=3013 /SigmaFactorBS="caatccggcagcattaagtgggttgatttgtaaaaaagtCTG GaagaaagagccaagaTATGCTGTAATGGTATAAAAccattgatggagggttctatgt a" /listShort="yocD" /listLong="des, S730, desK, desR" /label="upshifts" CDS 1918862..1919839 /gene="yocD" /locus_tag="BSU_19170" /old_locus_tag="BSU19170" /EC_number="3.4.17.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22516613; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative carboxypeptidase; aminoacid adenylate hydrolase (microcin resistance)" /protein_id="NP_389798.1" /db_xref="EnsemblGenomes-Gn:BSU19170" /db_xref="EnsemblGenomes-Tr:CAB13809" /db_xref="GOA:O35046" /db_xref="InterPro:IPR003507" /db_xref="InterPro:IPR027461" /db_xref="InterPro:IPR027478" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG13517" /db_xref="UniProtKB/Swiss-Prot:O35046" /translation="MYASKLKKGDEIRIVSPATSMSILSNEAKIQAKTALERLGYRVT IAEHANECNEFDSSSIESRVHDLHAAFFDPGVKAILTTLGGFNSNQLLRYLDYEKIKR HPKILCGYSDITALCNAIYQKTGLVTYSGPHFSTFAMKKGLDYTEEYFLSCCASDDPF EIHPSSEWSDDRWFLDQENRRFYPNNGPVVIQEGYAEGTLIGGNLCTLNLLQGTEYFP ETEHTILLIEDDYMSDIHMFDRDLQSLIHLPAFSHVKAILIGRFQKASNVSIDLVKAM IETKKELSGIPIIANINAGHTSPIATFPIGGTCRIEAISGTSRIWIDKH*" /label="yocD CDS" gene 1918862..1919839 /gene="yocD" /locus_tag="BSU_19170" /old_locus_tag="BSU19170" /label="yocD gene" downshifts 1919811 /Source="Nicolas_upshifts" /id="D1052" /incds=0 /nref=131 /ntot=256 /MaxReadThrough="3.77491" /MaxDrop="4.2254" /score="1.66373432" /energy="-9.5" /TU="U1558,U1559" /idTUdmin="U1558" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" promotor_-35 1919936..1919943 /Source="Nicolas_upshift_promotors" /id="U1560" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.503496503496504" /psig="0.85914085914086" /xcortree=311 /SigmaFactorBS="acaaatgtcatataggaggcatgatgtgtgcTACTACAAaag acttctctcatTAGCGTATACTGAACCGAGAcacacaatgagaggatacttactatga c" /listShort="des, S730, desK, desR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1919958..1919977 /Source="Nicolas_upshift_promotors" /id="U1560" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.503496503496504" /psig="0.85914085914086" /xcortree=311 /SigmaFactorBS="acaaatgtcatataggaggcatgatgtgtgcTACTACAAaag acttctctcatTAGCGTATACTGAACCGAGAcacacaatgagaggatacttactatga c" /listShort="des, S730, desK, desR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1919965 /Source="Nicolas_upshifts" /id="U1560" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.503496503496504" /psig="0.85914085914086" /xcortree=311 /SigmaFactorBS="acaaatgtcatataggaggcatgatgtgtgcTACTACAAaag acttctctcatTAGCGTATACTGAACCGAGAcacacaatgagaggatacttactatga c" /listShort="des, S730, desK, desR" /GFF_Attribute="listLong" /label="upshifts" CDS 1920001..1921059 /gene="desE" /locus_tag="BSU_19180" /old_locus_tag="BSU19180" /EC_number="1.14.19.-" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9555904, 11717295, 12207704, 15247225, 15711796, 16105701, 28546427" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9555904, 11717295, 12207704, 15247225, 15711796, 16105701, 28546427; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fatty acid desaturase" /protein_id="NP_389799.1" /db_xref="EnsemblGenomes-Gn:BSU19180" /db_xref="EnsemblGenomes-Tr:CAB13810" /db_xref="GOA:O34653" /db_xref="InterPro:IPR005804" /db_xref="SubtiList:BG13518" /db_xref="UniProtKB/Swiss-Prot:O34653" /translation="MTEQTIAHKQKQLTKQVAAFAQPETKNSLIQLLNTFIPFFGLWF LAYLSLDVSYLLTLALTVIAAGFLTRIFIIFHDCCHQSFFKQKRYNHILGFLTGVLTL FPYLQWQHSHSIHHATSSNLDKRGTGDIWMLTVNEYKAASRRTKLAYRLYRNPFIMFI LGPIYVFLITNRFNKKGARRKERVNTYLTNLAIVALAAACCLIFGWQSFLLVQGPIFL ISGSIGVWLFYVQHTFEDSYFEADENWSYVQAAVEGSSFYKLPKLLQWLTGNIGYHHV HHLSPKVPNYKLEVAHEHHEPLKNVPTITLKTSLQSLAFRLWDEDNKQFVSFRAIKHI PVSLPPDSPEKQKLRKNA*" /label="desE CDS" gene 1920001..1921059 /gene="desE" /locus_tag="BSU_19180" /old_locus_tag="BSU19180" /label="desE gene" S_feature 1921060..1921129 /Source="Nicolas_S_feature" /locus_tag="new_2090455_2090524" /HighExp="Cold, S8, LoTm, Sw, Paraq, BC, S7, S0, Oxctl, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.859" /TUlongSig="SigA, SigA" /TUlongPSig="0.984, 1" /label="S730" promotor_-35 1921113..1921119 /Source="Nicolas_upshift_promotors" /id="U1561" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.97002997002997" /psig="0.999000999001" /xcortree=3111 /SigmaFactorBS="gtcttctaatatactagaaggcttcctttttattgttggagg GTGCATTctggctttcacAATGATAAAGTTACAAGTAAgatgaaaagctgaaaatgag g" /listShort="desK, desR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1921131..1921150 /Source="Nicolas_upshift_promotors" /id="U1561" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.97002997002997" /psig="0.999000999001" /xcortree=3111 /SigmaFactorBS="gtcttctaatatactagaaggcttcctttttattgttggagg GTGCATTctggctttcacAATGATAAAGTTACAAGTAAgatgaaaagctgaaaatgag g" /listShort="desK, desR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1921131 /Source="Nicolas_upshifts" /id="U1561" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.97002997002997" /psig="0.999000999001" /xcortree=3111 /SigmaFactorBS="gtcttctaatatactagaaggcttcctttttattgttggagg GTGCATTctggctttcacAATGATAAAGTTACAAGTAAgatgaaaagctgaaaatgag g" /listShort="desK, desR" /GFF_Attribute="listLong" /label="upshifts" CDS 1921179..1922291 /gene="desK" /locus_tag="BSU_19190" /old_locus_tag="BSU19190" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11285232, 11717295, 12207704, 14734164, 15090506, 15711796, 23356219, 24574048, 26172072, 28475313" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11285232, 11717295, 12207704, 14734164, 15090506, 15711796, 23356219, 24574048, 26172072, 28475313; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component thermosensor histidine kinase [DesR-DesK]" /protein_id="NP_389800.1" /db_xref="EnsemblGenomes-Gn:BSU19190" /db_xref="EnsemblGenomes-Tr:CAB13811" /db_xref="GOA:O34757" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR036890" /db_xref="PDB:3EHF" /db_xref="PDB:3EHG" /db_xref="PDB:3EHH" /db_xref="PDB:3EHJ" /db_xref="PDB:3GIE" /db_xref="PDB:3GIF" /db_xref="PDB:3GIG" /db_xref="PDB:5IUJ" /db_xref="PDB:5IUK" /db_xref="PDB:5IUL" /db_xref="PDB:5IUM" /db_xref="PDB:5IUN" /db_xref="SubtiList:BG13519" /db_xref="UniProtKB/Swiss-Prot:O34757" /translation="MIKNHFTFQKLNGITPYIWTIFFILPFYFIWKSSSTFVIIVGII LTLLFFSVYRFAFVSKGWTIYLWGFLLIGISTASITLFSYIYFAFFIAYFIGNIKERV PFHILYYVHLISAAVAANFSLVLKKEFFLTQIPFVVITLISAILLPFSIKSRKERERL EEKLEDANERIAELVKLEERQRIARDLHDTLGQKLSLIGLKSDLARKLIYKDPEQAAR ELKSVQQTARTSLNEVRKIVSSMKGIRLKDELINIKQILEAADIMFIYEEEKWPENIS LLNENILSMCLKEAVTNVVKHSQAKTCRVDIQQLWKEVVITVSDDGTFKGEENSFSKG HGLLGMRERLEFANGSLHIDTENGTKLTMAIPNNSK*" /label="desK CDS" gene 1921179..1922291 /gene="desK" /locus_tag="BSU_19190" /old_locus_tag="BSU19190" /label="desK gene" CDS 1922310..1922909 /gene="desR" /locus_tag="BSU_19200" /old_locus_tag="BSU19200" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11285232, 11717295, 12207704, 14734164, 15090506, 15711796, 19595746, 20581210, 24574048" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11285232, 11717295, 12207704, 14734164, 15090506, 15711796, 19595746, 20581210, 24574048; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [DesK]" /protein_id="NP_389801.1" /db_xref="EnsemblGenomes-Gn:BSU19200" /db_xref="EnsemblGenomes-Tr:CAB13812" /db_xref="GOA:O34723" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="PDB:4LDZ" /db_xref="PDB:4LE0" /db_xref="PDB:4LE1" /db_xref="PDB:4LE2" /db_xref="PDB:5IUJ" /db_xref="PDB:5IUK" /db_xref="PDB:5IUL" /db_xref="PDB:5IUN" /db_xref="SubtiList:BG13520" /db_xref="UniProtKB/Swiss-Prot:O34723" /translation="MISIFIAEDQQMLLGALGSLLNLEDDMEVVGKGTTGQDAVDFVK KRQPDVCIMDIEMPGKTGLEAAEELKDTGCKIIILTTFARPGYFQRAIKAGVKGYLLK DSPSEELANAIRSVMNGKRIYAPELMEDLYSEANPLTDREKEVLELVADGKNTKEIAQ ELSIKSGTVRNYISMILEKLEVKNRIEAITRSKEKGWFK*" /label="desR CDS" gene 1922310..1922909 /gene="desR" /locus_tag="BSU_19200" /old_locus_tag="BSU19200" /label="desR gene" downshifts 1922847 /Source="Nicolas_upshifts" /id="D1053" /incds=1 /nref=1 /ntot=41 /MaxReadThrough="4.44811" /MaxDrop="2.78724" /score="23.648858" /energy="-15.4" /TU="U1560" /idTUdmin="U1560" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" downshifts 1922891 /Source="Nicolas_upshifts" /id="D1054" /incds=0 /nref=1 /ntot=68 /MaxReadThrough="1.88273" /MaxDrop="3.38398" /score="23.648858" /energy="-15.4" /TU="NA" /idTUdmin="U1560" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1922931..1923429) /Source="Nicolas_S_feature" /locus_tag="new_2092326_2092824_c" /HighExp="S4, LoTm, S6, S3, S5, S8, S7, B36, T5.0H, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.230296" /TUshortSig="SigEF" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S731" downshifts complement(1922967) /Source="Nicolas_upshifts" /id="D1055" /incds=0 /nref=3 /ntot=21 /MaxReadThrough="1.62146" /MaxDrop="5.61121" /score="23.7393309" /energy="-12.4" /TU="NA" /idTUdmin="U1563" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 1923401..1923410 /Source="Nicolas_upshift_promotors" /id="U1562" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1329 /SigmaFactorBS="tcttttaacccgagagcccctgaatcgcacataaagaaaAAC GGGACCActttcttttatcAGCATATGATATAAACAGCTctaagcagaacaaaaaaag a" /listShort="S732, S733" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1923413..1923431) /Source="Nicolas_upshift_promotors" /id="U1563" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1169 /SigmaFactorBS="ataaaagacataagcttttggcttgtgtctttttttGTTCTG cttagagctgtttataTCATATGCTGATAAAAGAAagtggtcccgtttttctttatgt g" /listShort="S731" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1923422..1923616 /Source="Nicolas_S_feature" /locus_tag="new_2092817_2093011" /HighExp="S6, S8, S7, BT, B36, Pyr, G/S, C30, S5, B60" /AntisenseName="yocH" /AntisenseCor="0.113870403460631" /AntisenseRegPval="-1.2" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S732" upshifts 1923422 /Source="Nicolas_upshifts" /id="U1562" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1329 /SigmaFactorBS="tcttttaacccgagagcccctgaatcgcacataaagaaaAAC GGGACCActttcttttatcAGCATATGATATAAACAGCTctaagcagaacaaaaaaag a" /listShort="S732, S733" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1923423..1923442 /Source="Nicolas_upshift_promotors" /id="U1562" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1329 /SigmaFactorBS="tcttttaacccgagagcccctgaatcgcacataaagaaaAAC GGGACCActttcttttatcAGCATATGATATAAACAGCTctaagcagaacaaaaaaag a" /listShort="S732, S733" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1923429) /Source="Nicolas_upshifts" /id="U1563" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1169 /SigmaFactorBS="ataaaagacataagcttttggcttgtgtctttttttGTTCTG cttagagctgtttataTCATATGCTGATAAAAGAAagtggtcccgtttttctttatgt g" /listShort="S731" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1923448..1923453) /Source="Nicolas_upshift_promotors" /id="U1563" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1169 /SigmaFactorBS="ataaaagacataagcttttggcttgtgtctttttttGTTCTG cttagagctgtttataTCATATGCTGATAAAAGAAagtggtcccgtttttctttatgt g" /listShort="S731" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1923504..1924367) /gene="walL" /locus_tag="BSU_19210" /old_locus_tag="BSU19210" /EC_number="3.2.1.-" /function="16.6: Maintain" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:17307850, 20070526, 20487291, 26102633" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17307850, 20070526, 20487291, 26102633; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exported cell wall lytic enzyme" /protein_id="NP_389802.1" /db_xref="EnsemblGenomes-Gn:BSU19210" /db_xref="EnsemblGenomes-Tr:CAB13813" /db_xref="GOA:O34669" /db_xref="InterPro:IPR010611" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="InterPro:IPR036908" /db_xref="SubtiList:BG13521" /db_xref="UniProtKB/Swiss-Prot:O34669" /translation="MKKTIMSFVAVAALSTTAFGAHASAKEITVQKGDTLWGISQKNG VNLKDLKEWNKLTSDKIIAGEKLTISSEETTTTGQYTIKAGDTLSKIAQKFGTTVNNL KVWNNLSSDMIYAGSTLSVKGQATAANTATENAQTNAPQAAPKQEAVQKEQPKQEAVQ QQPKQETKAEAETSVNTEEKAVQSNTNNQEASKELTVTATAYTANDGGISGVTATGID LNKNPNAKVIAVDPNVIPLGSKVYVEGYGEATAADTGGAIKGNKIDVFVPSKSDASNW GVKTVSVKVLN*" /label="walL CDS" gene complement(1923504..1924367) /gene="walL" /locus_tag="BSU_19210" /old_locus_tag="BSU19210" /label="walL gene" downshifts complement(1923517) /Source="Nicolas_upshifts" /id="D1056" /incds=0 /nref=227 /ntot=262 /MaxReadThrough="2.55593" /MaxDrop="7.59881" /score="23.8272007" /energy="-10.2" /TU="U1565" /idTUdmin="U1565" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" downshifts 1923573 /Source="Nicolas_upshifts" /id="D1057" /incds=1 /nref=8 /ntot=28 /MaxReadThrough="6.14664" /MaxDrop="3.95582" /score="23.648858" /energy="-15.4" /TU="U1562" /idTUdmin="U1560" /TUdmin=682 /isTUend="FALSE" /label="downshifts" downshifts complement(1923605) /Source="Nicolas_upshifts" /id="D1058" /incds=1 /nref=10 /ntot=161 /MaxReadThrough="7.34609" /MaxDrop="3.8459" /score="23.8272007" /energy="-10.2" /TU="U1565" /idTUdmin="U1565" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" S_feature 1923618..1924385 /Source="Nicolas_S_feature" /locus_tag="new_2093013_2093780" /HighExp="BT, S8, S6, Gly, S7, C30, G135, G/S, Fru, Pyr" /AntisenseName="yocH" /AntisenseCor="-0.12155468325348801" /AntisenseRegPval="-1.3" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S733" promotor_-35 1924363..1924367 /Source="Nicolas_upshift_promotors" /id="U1564" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=1239 /SigmaFactorBS="agtgcagcaactgccacaaaggacataatcgtcttcTTCATa agtaaatCCTCCCTTGTTAGCTttttattggcggctaacaggtgatatcgtaacacac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1924376..1924390 /Source="Nicolas_upshift_promotors" /id="U1564" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=1239 /SigmaFactorBS="agtgcagcaactgccacaaaggacataatcgtcttcTTCATa agtaaatCCTCCCTTGTTAGCTttttattggcggctaacaggtgatatcgtaacacac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1924387 /Source="Nicolas_upshifts" /id="U1564" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=1239 /SigmaFactorBS="agtgcagcaactgccacaaaggacataatcgtcttcTTCATa agtaaatCCTCCCTTGTTAGCTttttattggcggctaacaggtgatatcgtaacacac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1924406..1924425) /Source="Nicolas_upshift_promotors" /id="U1565" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig="0.999000999001" /xcortree=582 /SigmaFactorBS="gtaaaggaactgtaatctaaatcatatctttttgttATTGAT TtgacatttacgTGTGTTACGATATCACCTGTtagccgccaataaaaagctaacaagg g" /listShort="yocH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1924419) /Source="Nicolas_upshifts" /id="U1565" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig="0.999000999001" /xcortree=582 /SigmaFactorBS="gtaaaggaactgtaatctaaatcatatctttttgttATTGAT TtgacatttacgTGTGTTACGATATCACCTGTtagccgccaataaaaagctaacaagg g" /listShort="yocH" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1924421..1924614) /Source="Nicolas_S_feature" /locus_tag="new_2093816_2094009_c" /HighExp="LoTm, HiOs, S8, C30, S2, G135, G180, T5.0H, S7, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S734" promotor_-35 complement(1924437..1924443) /Source="Nicolas_upshift_promotors" /id="U1565" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig="0.999000999001" /xcortree=582 /SigmaFactorBS="gtaaaggaactgtaatctaaatcatatctttttgttATTGAT TtgacatttacgTGTGTTACGATATCACCTGTtagccgccaataaaaagctaacaagg g" /listShort="yocH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1924615..1926390) /gene="recQ" /locus_tag="BSU_19220" /old_locus_tag="BSU19220" /EC_number="3.6.1.12" /experiment="publication(s) with functional evidences, PMID:11886746, 16385024, 22200572, 25246477, 26001966" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11886746, 16385024, 22200572, 25246477, 26001966; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent helicase" /protein_id="NP_389803.1" /db_xref="EnsemblGenomes-Gn:BSU19220" /db_xref="EnsemblGenomes-Tr:CAB13814" /db_xref="GOA:O34748" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR002121" /db_xref="InterPro:IPR004589" /db_xref="InterPro:IPR006293" /db_xref="InterPro:IPR010997" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR018982" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR032284" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13522" /db_xref="UniProtKB/Swiss-Prot:O34748" /translation="MLHRAQSLLAHYFGYEKFRSGQDEAIRLVTEARQNTACIMPTGG GKSICYQIPALMFEGTTIVISPLISLMKDQVDALEEAGINAAYINSTQSNQEIYERLN GLKEGAYKLFYITPERLTSIEFIRILQGIDVPLVAIDEAHCISQWGHDFRPSYRNIEI LFRELHDKPVIMALTATATPEVHDDICKQLHIQKENTVYTGFSRENLTFKVVKGENKD RFIDEYVQNNRHEAGIVYTATRKEADRIYERLKRNQVRAGRYHGGLADDVRKEQQERF LNDELQVMVATSAFGMGIDKSNIRFVLHAQIPKDMESYYQEAGRAGRDGLASECVLLF SPQDIMVQRFLIEQSEHEEKQKQDLKKLRQMVDYCHTEDCLQRFILMYFGEKEPDACG QCGNCTDTRAAHDVTREAQMVLSCIIRMKERFGKTMVAQVLAGSKNKKVLENGFSDLS TYGILKHQSVGEISDFIEFLISDDFIRMSDGTFPTLFVSSKGRNVLKGELSVARKEAL KAAAITENDELFERLRMVRKEIAAEQGVPPFVVFSDQTLKEMSGKQPVNDDELLSIKG VGEQKRAKYGRLFLQEIQAYARMTD*" /label="recQ CDS" gene complement(1924615..1926390) /gene="recQ" /locus_tag="BSU_19220" /old_locus_tag="BSU19220" /label="recQ gene" S_feature complement(1926391..1926521) /Source="Nicolas_S_feature" /locus_tag="new_2095786_2095916_c" /HighExp="LoTm, G180, Cold, G135, G150, T5.0H, T4.0H, T3.30H, S2, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S735" misc_RNA complement(1926514..1926716) /gene="ssrSA" /locus_tag="BSU_misc_RNA_32" /product="6Sa RNA" /experiment="publication(s) with functional evidences, PMID:11886746, 15793584, 15811922, 22333917, 25576829, 26873600" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11886746, 15793584, 15811922, 22333917, 25576829, 26873600; Product type n : RNA" /label="ssrSA RNA" gene complement(1926514..1926716) /gene="ssrSA" /locus_tag="BSU_misc_RNA_32" /label="ssrSA gene" downshifts complement(1926566) /Source="Nicolas_upshifts" /id="D1059" /incds=0 /nref=34 /ntot=297 /MaxReadThrough="4.06142" /MaxDrop="7.97725" /score="26.8190437" /energy="-12.7" /TU="U1566" /idTUdmin="U1568" /TUdmin=163 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1926714..1926733) /Source="Nicolas_upshift_promotors" /id="U1566" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.554445554445554" /psig=1 /xcortree=418 /SigmaFactorBS="attcactggaaaaagtttttctaaacaattgttctgaccTCT TGATTaaaagcgcctgaTGGTGTACTATATTAAAGAAgctactttgtgcgtattgtta a" /listShort="NA, S735, yocI, S734" /listLong="yocH" /label="promotor_-10" upshifts complement(1926732) /Source="Nicolas_upshifts" /id="U1566" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.554445554445554" /psig=1 /xcortree=418 /SigmaFactorBS="attcactggaaaaagtttttctaaacaattgttctgaccTCT TGATTaaaagcgcctgaTGGTGTACTATATTAAAGAAgctactttgtgcgtattgtta a" /listShort="NA, S735, yocI, S734" /listLong="yocH" /label="upshifts" S_feature complement(1926734..1926926) /Source="Nicolas_S_feature" /locus_tag="new_2096129_2096321_c" /HighExp="dia5, Etha, dia15, Diami, S8, S7, C30, G180, G135, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S736" promotor_-35 complement(1926746..1926753) /Source="Nicolas_upshift_promotors" /id="U1566" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.554445554445554" /psig=1 /xcortree=418 /SigmaFactorBS="attcactggaaaaagtttttctaaacaattgttctgaccTCT TGATTaaaagcgcctgaTGGTGTACTATATTAAAGAAgctactttgtgcgtattgtta a" /listShort="NA, S735, yocI, S734" /listLong="yocH" /label="promotor_-35" CDS complement(1926955..1927581) /gene="azoJ" /locus_tag="BSU_19230" /old_locus_tag="BSU19230" /EC_number="1.7.-.-" /experiment="publication(s) with functional evidences, PMID:11886746, 18208493, 22200572" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11886746, 18208493, 22200572; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="FMN-dependent NADH-azoreductase" /protein_id="NP_389804.1" /db_xref="EnsemblGenomes-Gn:BSU19230" /db_xref="EnsemblGenomes-Tr:CAB13815" /db_xref="GOA:O35022" /db_xref="InterPro:IPR003680" /db_xref="InterPro:IPR023048" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG13523" /db_xref="UniProtKB/Swiss-Prot:O35022" /translation="MSTVLFVKSSDRTAEEGVSTKLYEAFLAAYKENNPNDEVVELDL HKENLPYLGRDMINGTFKAGQGMEMTEDEKKQAAIADKYLNQFVKADKVVFAFPLWNF TVPAVLHTYVDYLSRAGVTFKYTQEGPVGLMGGKKVALLNARGGVYSEGPMAALEMSL NFMKTVLGFWGVQDLHTVVIEGHNAAPDQAQEIVEKGLQEAKDLAAKF*" /label="azoJ CDS" gene complement(1926955..1927581) /gene="azoJ" /locus_tag="BSU_19230" /old_locus_tag="BSU19230" /label="azoJ gene" downshifts complement(1926971) /Source="Nicolas_upshifts" /id="D1060" /incds=0 /nref=68 /ntot=205 /MaxReadThrough="5.10353" /MaxDrop="5.66408" /score="1.15982687" /energy="-10.9" /TU="U1567,U1568" /idTUdmin="U1567" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1927615..1927634) /Source="Nicolas_upshift_promotors" /id="U1567" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.682317682317682" /psig=1 /xcortree=1846 /SigmaFactorBS="tttgaaaaaaaatctcatattcaaaataaagtgATTGACTTt acgtaaaaaagaAAGTAACATACTATTTGTAAgtaaatataaaaagtttaccgggagg a" /listShort="yocJ, S736" /listLong="NA, S735, yocI, S734, yocH" /label="promotor_-10" upshifts complement(1927628) /Source="Nicolas_upshifts" /id="U1567" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.682317682317682" /psig=1 /xcortree=1846 /SigmaFactorBS="tttgaaaaaaaatctcatattcaaaataaagtgATTGACTTt acgtaaaaaagaAAGTAACATACTATTTGTAAgtaaatataaaaagtttaccgggagg a" /listShort="yocJ, S736" /listLong="NA, S735, yocI, S734, yocH" /label="upshifts" promotor_-35 complement(1927648..1927655) /Source="Nicolas_upshift_promotors" /id="U1567" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.682317682317682" /psig=1 /xcortree=1846 /SigmaFactorBS="tttgaaaaaaaatctcatattcaaaataaagtgATTGACTTt acgtaaaaaagaAAGTAACATACTATTTGTAAgtaaatataaaaagtttaccgggagg a" /listShort="yocJ, S736" /listLong="NA, S735, yocI, S734, yocH" /label="promotor_-35" CDS complement(1927732..1928223) /gene="yocK" /locus_tag="BSU_19240" /old_locus_tag="BSU19240" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10220166, 15496987, 15496987; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative general stress protein" /protein_id="NP_389805.2" /db_xref="EnsemblGenomes-Gn:BSU19240" /db_xref="EnsemblGenomes-Tr:CAB13816" /db_xref="GOA:P80872" /db_xref="InterPro:IPR000962" /db_xref="InterPro:IPR020458" /db_xref="InterPro:IPR037187" /db_xref="SubtiList:BG13524" /db_xref="UniProtKB/Swiss-Prot:P80872" /translation="MALTKEQTQHLYHKLLDMQKELSGEKKETESMTEEVGELSNGVD NHMADHGTLVTDRMTDQTVKEIDRELLEEVNRALQKMKDGTYGVCEKTGQEIPYERLE AVPYARMTVEAQADVEDDLETDAPSYEREFHEQVKDLSNKETIDQKSSQTYEILDREQ DSK*" /label="yocK CDS" gene complement(1927732..1928223) /gene="yocK" /locus_tag="BSU_19240" /old_locus_tag="BSU19240" /label="yocK gene" downshifts complement(1927741) /Source="Nicolas_upshifts" /id="D1061" /incds=0 /nref=5 /ntot=49 /MaxReadThrough="7.79466" /MaxDrop="4.30433" /score="1.15982687" /energy="-10.9" /TU="U1568,U1573" /idTUdmin="U1571" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1928235..1928253) /Source="Nicolas_upshift_promotors" /id="U1568" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=238 /SigmaFactorBS="aaggcagtagctcatctttccatcgatgtttccaTGTTTGAc agaaggcaaaacGGGAAACAGGATAGAAAGGagaggatatacatggcactgacaaaag a" /listShort="yocK, yocJ, S736" /listLong="NA" /label="promotor_-10" upshifts complement(1928247) /Source="Nicolas_upshifts" /id="U1568" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=238 /SigmaFactorBS="aaggcagtagctcatctttccatcgatgtttccaTGTTTGAc agaaggcaaaacGGGAAACAGGATAGAAAGGagaggatatacatggcactgacaaaag a" /listShort="yocK, yocJ, S736" /listLong="NA" /label="upshifts" promotor_-35 complement(1928267..1928273) /Source="Nicolas_upshift_promotors" /id="U1568" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=238 /SigmaFactorBS="aaggcagtagctcatctttccatcgatgtttccaTGTTTGAc agaaggcaaaacGGGAAACAGGATAGAAAGGagaggatatacatggcactgacaaaag a" /listShort="yocK, yocJ, S736" /listLong="NA" /label="promotor_-35" CDS complement(1928298..1928630) /gene="yocL" /locus_tag="BSU_19250" /old_locus_tag="BSU19250" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 21926231" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389806.1" /db_xref="EnsemblGenomes-Gn:BSU19250" /db_xref="EnsemblGenomes-Tr:CAB13817" /db_xref="SubtiList:BG13525" /db_xref="UniProtKB/Swiss-Prot:O34976" /translation="MKKMFRSLIRHCLKPELDKLRECEERLSVIEKQKQSSKQESEET YIHIETLNVEKVDYHLEFGELTIDELSGRLNIGATYYIPPEEKDKKCQRKPEAPSTPA VTIRSKRQ*" /label="yocL CDS" gene complement(1928298..1928630) /gene="yocL" /locus_tag="BSU_19250" /old_locus_tag="BSU19250" /label="yocL gene" S_feature complement(1928631..1928921) /Source="Nicolas_S_feature" /locus_tag="new_2098025_2098315_c" /HighExp="Salt, Cold, S3, S8, S4, S7, T5.0H, T3.30H, S6, T4.0H" /AntisenseName="yoyB" /AntisenseCor="0.489341986454357" /AntisenseRegPval="-16.899999999999999" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA, SigWXY" /TUshortPSig="0.698, 0.799, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S737" promotor_-35 1928646..1928651 /Source="Nicolas_upshift_promotors" /id="U1569" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.877122877122877" /psig="0.877122877122877" /xcortree=1142 /SigmaFactorBS="agcgaccggaacatttttttcatgacatcacgacccttTGCA TActcctctttcgtctACATATATAATGAGGTATAtcccatagaaaggagaggttttc a" /listShort="yoyB, S738" /listLong="yozN, yocN" /label="promotor_-35" promotor_-10 1928666..1928684 /Source="Nicolas_upshift_promotors" /id="U1569" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.877122877122877" /psig="0.877122877122877" /xcortree=1142 /SigmaFactorBS="agcgaccggaacatttttttcatgacatcacgacccttTGCA TActcctctttcgtctACATATATAATGAGGTATAtcccatagaaaggagaggttttc a" /listShort="yoyB, S738" /listLong="yozN, yocN" /label="promotor_-10" upshifts 1928668 /Source="Nicolas_upshifts" /id="U1569" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.877122877122877" /psig="0.877122877122877" /xcortree=1142 /SigmaFactorBS="agcgaccggaacatttttttcatgacatcacgacccttTGCA TActcctctttcgtctACATATATAATGAGGTATAtcccatagaaaggagaggttttc a" /listShort="yoyB, S738" /listLong="yozN, yocN" /label="upshifts" CDS 1928708..1928935 /gene="yoyB" /locus_tag="BSU_19259" /old_locus_tag="BSU19259" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 19383706, 20709900" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097740.1" /db_xref="EnsemblGenomes-Gn:BSU19259" /db_xref="EnsemblGenomes-Tr:CAX52637" /db_xref="UniProtKB/Swiss-Prot:C0H429" /translation="MLPTNINISHLKTNSIGTGSSLTFGSAELRNRCSAIKRNNGFGE QNADGIVMVIPIESIDDRDVSDALSMKINHQ*" /label="yoyB CDS" gene 1928708..1928935 /gene="yoyB" /locus_tag="BSU_19259" /old_locus_tag="BSU19259" /label="yoyB gene" CDS complement(1928922..1929398) /gene="yocM" /locus_tag="BSU_19260" /old_locus_tag="BSU19260" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11150673, 23155385; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative chaperone" /protein_id="NP_389808.1" /db_xref="EnsemblGenomes-Gn:BSU19260" /db_xref="EnsemblGenomes-Tr:CAB13818" /db_xref="InterPro:IPR002068" /db_xref="InterPro:IPR008978" /db_xref="InterPro:IPR031107" /db_xref="SubtiList:BG13526" /db_xref="UniProtKB/Swiss-Prot:O34321" /translation="MDFEKMKQWMEFAQQMYGGDFWKQVFDEDQKTPFMTNGQSPFPF AQQDQRGKGDASFPSMDIVDTVAEVQFLIYLPGYRKQDVHILSYGDYLVVKGQRFSYF NEQDFRQKEGKYGSFEKKIPLSDHLHGKMNAIFKDGILYITIQKDEGQAKTIVIDD*" /label="yocM CDS" gene complement(1928922..1929398) /gene="yocM" /locus_tag="BSU_19260" /old_locus_tag="BSU19260" /label="yocM gene" S_feature 1928936..1929443 /Source="Nicolas_S_feature" /locus_tag="new_2098330_2098837" /HighExp="S6, S5, S8, S7, S4, B36, BT, S3, T5.0H, LoTm" /AntisenseName="yocM" /AntisenseCor="0.54530996552252997" /AntisenseRegPval="-21.5" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.877" /TUlongSig="NA" /TUlongPSig="NA" /label="S738" S_feature complement(1929399..1929501) /Source="Nicolas_S_feature" /locus_tag="new_2098793_2098895_c" /HighExp="Cold, Salt, S8, T5.0H, S3, T-0.40H, T0.0H, S4, T4.0H, S6" /AntisenseName="yozN" /AntisenseCor="0.471443110130365" /AntisenseRegPval="-15.6" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA, SigWXY" /TUshortPSig="0.698, 0.799, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S739" promotor_-35 1929416..1929421 /Source="Nicolas_upshift_promotors" /id="U1570" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1089 /SigmaFactorBS="ttttcgaaatccatttgaagccccctgtcttAACATActtta taaccgccaGCATACAACTATAGAAAGGaggtttgcctgtggttcaaccaactccgta t" /listShort="yozN, yocN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1929436..1929454 /Source="Nicolas_upshift_promotors" /id="U1570" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1089 /SigmaFactorBS="ttttcgaaatccatttgaagccccctgtcttAACATActtta taaccgccaGCATACAACTATAGAAAGGaggtttgcctgtggttcaaccaactccgta t" /listShort="yozN, yocN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1929445 /Source="Nicolas_upshifts" /id="U1570" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1089 /SigmaFactorBS="ttttcgaaatccatttgaagccccctgtcttAACATActtta taaccgccaGCATACAACTATAGAAAGGaggtttgcctgtggttcaaccaactccgta t" /listShort="yozN, yocN" /GFF_Attribute="listLong" /label="upshifts" CDS 1929465..1929728 /gene="yozN" /locus_tag="BSU_19270" /old_locus_tag="BSU19270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 20709900" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (mother cell in sporulation)" /protein_id="NP_389809.1" /db_xref="EnsemblGenomes-Gn:BSU19270" /db_xref="EnsemblGenomes-Tr:CAB13819" /db_xref="SubtiList:BG13761" /db_xref="UniProtKB/Swiss-Prot:O31846" /translation="MVQPTPYININIFMLKINSFENASAVNVGQNLLAEWQNSDKKNQ GYGQNFGDASGFMGTRSHVDDRDQIDSPASFESEAVNSSIKRK*" /label="yozN CDS" gene 1929465..1929728 /gene="yozN" /locus_tag="BSU_19270" /old_locus_tag="BSU19270" /label="yozN gene" promotor_-10 complement(1929481..1929500) /Source="Nicolas_upshift_promotors" /id="U1571" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.698301698301698" /psig="0.698301698301698" /xcortree=1042 /SigmaFactorBS="ataaattttgtcctacgttaaccgctgaagcattttcaaagg aATTAAttttcagcatgaaAATATTAATATTGATATACGgagttggttgaaccacagg c" /listShort="S739, yocM, S737, yocL, yocK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1929501) /Source="Nicolas_upshifts" /id="U1571" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.698301698301698" /psig="0.698301698301698" /xcortree=1042 /SigmaFactorBS="ataaattttgtcctacgttaaccgctgaagcattttcaaagg aATTAAttttcagcatgaaAATATTAATATTGATATACGgagttggttgaaccacagg c" /listShort="S739, yocM, S737, yocL, yocK" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1929503..1930028) /Source="Nicolas_S_feature" /locus_tag="new_2098897_2099422_c" /HighExp="Salt, Cold, T-0.40H, T0.0H, T0.30H, T-1.10H, T-1.40H, T3.30H, T2.0H, S0" /AntisenseName="yocN" /AntisenseCor="-0.51964820699949898" /AntisenseRegPval="-19.3" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigWXY" /TUshortPSig="0.799, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S740" promotor_-35 complement(1929514..1929518) /Source="Nicolas_upshift_promotors" /id="U1571" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.698301698301698" /psig="0.698301698301698" /xcortree=1042 /SigmaFactorBS="ataaattttgtcctacgttaaccgctgaagcattttcaaagg aATTAAttttcagcatgaaAATATTAATATTGATATACGgagttggttgaaccacagg c" /listShort="S739, yocM, S737, yocL, yocK" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1929733..1929966 /gene="yocN" /locus_tag="BSU_19280" /old_locus_tag="BSU19280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 20709900" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (sporulation-related)" /protein_id="NP_389810.1" /db_xref="EnsemblGenomes-Gn:BSU19280" /db_xref="EnsemblGenomes-Tr:CAB13820" /db_xref="SubtiList:BG13527" /db_xref="UniProtKB/Swiss-Prot:O34855" /translation="MFFSPSVVNVGGFKINTMDRGSSLTLGPYQQVDYFLSAKINQGF GEENGDFTPLVVPISNVLDADLVDSNSAKNSVV*" /label="yocN CDS" gene 1929733..1929966 /gene="yocN" /locus_tag="BSU_19280" /old_locus_tag="BSU19280" /label="yocN gene" downshifts 1929953 /Source="Nicolas_upshifts" /id="D1062" /incds=0 /nref=62 /ntot=90 /MaxReadThrough="2.0117" /MaxDrop="7.59451" /score="5.68120132" /energy="-10.9" /TU="NA" /idTUdmin="U1570" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1930052..1930396) /gene="yozO" /locus_tag="BSU_19290" /old_locus_tag="BSU19290" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 23155385" /codon_start=1 /transl_table=11 /product="conserved hypothetical phage protein" /protein_id="NP_389811.1" /db_xref="EnsemblGenomes-Gn:BSU19290" /db_xref="EnsemblGenomes-Tr:CAB13821" /db_xref="InterPro:IPR011993" /db_xref="InterPro:IPR012544" /db_xref="InterPro:IPR037063" /db_xref="SubtiList:BG13762" /db_xref="UniProtKB/Swiss-Prot:O31847" /translation="MGIFSVSRSTDAKKLEALLVEGERIESIYKLRVDQICFTNKRII FFDNKMFSKKKVRVFLPYKTIESFAIQEAGMFDPDTGLLLMTRSKTFELEFAKDTDLS EVQAVLTKHLCS*" /label="yozO CDS" gene complement(1930052..1930396) /gene="yozO" /locus_tag="BSU_19290" /old_locus_tag="BSU19290" /label="yozO gene" downshifts complement(1930073) /Source="Nicolas_upshifts" /id="D1063" /incds=0 /nref=61 /ntot=217 /MaxReadThrough="4.58642" /MaxDrop="4.1868" /score="12.6520239" /energy="-9.6" /TU="U1572,U1573" /idTUdmin="U1574" /TUdmin=616 /isTUend="FALSE" /label="downshifts" S_feature complement(1930397..1930469) /Source="Nicolas_S_feature" /locus_tag="new_2099791_2099863_c" /HighExp="T0.30H, T0.0H, T1.0H, T-0.40H, T1.30H, T-1.10H, Salt, T2.0H, T-1.40H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigWXY" /TUshortPSig="0.799, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S741" promotor_-10 complement(1930465..1930484) /Source="Nicolas_upshift_promotors" /id="U1572" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.421578421578422" /psig="0.7992007992008" /xcortree=1714 /SigmaFactorBS="aatttgaaaaatgtaatctgttcgtaATGGTTtaaatgtctt ctaTGTCGTATTCTTATATAGGGataaaggacttatttttatgtagtgaatgataaaa c" /listShort="S741, yozO, S740, S739, yocM, S737, yocL, yocK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1930469) /Source="Nicolas_upshifts" /id="U1572" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.421578421578422" /psig="0.7992007992008" /xcortree=1714 /SigmaFactorBS="aatttgaaaaatgtaatctgttcgtaATGGTTtaaatgtctt ctaTGTCGTATTCTTATATAGGGataaaggacttatttttatgtagtgaatgataaaa c" /listShort="S741, yozO, S740, S739, yocM, S737, yocL, yocK" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1930471..1930574) /Source="Nicolas_S_feature" /locus_tag="new_2099865_2099968_c" /HighExp="T0.30H, T0.0H, T-0.40H, T1.0H, T1.30H, Salt, T-1.10H, T2.0H, T-1.40H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S742" promotor_-35 complement(1930498..1930503) /Source="Nicolas_upshift_promotors" /id="U1572" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.421578421578422" /psig="0.7992007992008" /xcortree=1714 /SigmaFactorBS="aatttgaaaaatgtaatctgttcgtaATGGTTtaaatgtctt ctaTGTCGTATTCTTATATAGGGataaaggacttatttttatgtagtgaatgataaaa c" /listShort="S741, yozO, S740, S739, yocM, S737, yocL, yocK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1930561..1930576) /Source="Nicolas_upshift_promotors" /id="U1573" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1697 /SigmaFactorBS="taaaaaccacttttttataaaaacattgctgaatatTGAAAC TTTTttctctatatgtGCGTATTACTTGATGAcaacagcttaaaagccaaaaaacaaa t" /listShort="S742, S741, yozO, S740, S739, yocM, S737, yocL, yocK, yocJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1930574) /Source="Nicolas_upshifts" /id="U1573" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1697 /SigmaFactorBS="taaaaaccacttttttataaaaacattgctgaatatTGAAAC TTTTttctctatatgtGCGTATTACTTGATGAcaacagcttaaaagccaaaaaacaaa t" /listShort="S742, S741, yozO, S740, S739, yocM, S737, yocL, yocK, yocJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1930589..1930598) /Source="Nicolas_upshift_promotors" /id="U1573" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1697 /SigmaFactorBS="taaaaaccacttttttataaaaacattgctgaatatTGAAAC TTTTttctctatatgtGCGTATTACTTGATGAcaacagcttaaaagccaaaaaacaaa t" /listShort="S742, S741, yozO, S740, S739, yocM, S737, yocL, yocK, yocJ" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(1930717) /Source="Nicolas_upshifts" /id="D1064" /incds=0 /nref=117 /ntot=269 /MaxReadThrough="5.5406" /MaxDrop="6.72115" /score="36.7697843" /energy="-10.7" /TU="U1574" /idTUdmin="U1576" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" CDS complement(1930753..1930956) /gene="yozC" /locus_tag="BSU_19300" /old_locus_tag="BSU19300" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389812.1" /db_xref="EnsemblGenomes-Gn:BSU19300" /db_xref="EnsemblGenomes-Tr:CAB13822" /db_xref="SubtiList:BG13750" /db_xref="UniProtKB/Swiss-Prot:O31848" /translation="MIHKNWLEKETIKKVKCVQTNAKKYIVNRVLTPGKEYEVKNETE EFLFVVDNTNKVGGYYKEYFEEM*" /label="yozC CDS" gene complement(1930753..1930956) /gene="yozC" /locus_tag="BSU_19300" /old_locus_tag="BSU19300" /label="yozC gene" promotor_-10 complement(1930977..1930996) /Source="Nicolas_upshift_promotors" /id="U1574" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=2988 /SigmaFactorBS="ataatagaaatcaaggcaaaatcaatgaataaccgaTATTGC AAtttacaaaagaaaaaAGCTACAATAAGCTTATAGAtaagaaaaggagatttcatca t" /listShort="yozC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1930995) /Source="Nicolas_upshifts" /id="U1574" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=2988 /SigmaFactorBS="ataatagaaatcaaggcaaaatcaatgaataaccgaTATTGC AAtttacaaaagaaaaaAGCTACAATAAGCTTATAGAtaagaaaaggagatttcatca t" /listShort="yozC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1930997..1931063) /Source="Nicolas_S_feature" /locus_tag="new_2100391_2100457_c" /HighExp="S7, S8, S6, S5, C30, S4, T4.0H, B60, BC, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.461" /TUlongSig="NA" /TUlongPSig="NA" /label="S743" promotor_-35 complement(1931012..1931019) /Source="Nicolas_upshift_promotors" /id="U1574" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.938061938061938" /psig=1 /xcortree=2988 /SigmaFactorBS="ataatagaaatcaaggcaaaatcaatgaataaccgaTATTGC AAtttacaaaagaaaaaAGCTACAATAAGCTTATAGAtaagaaaaggagatttcatca t" /listShort="yozC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1931029..1931036 /Source="Nicolas_upshift_promotors" /id="U1575" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.59040959040959" /psig="0.96103896103896" /xcortree=509 /SigmaFactorBS="attgtagcttttttcttttgtaaattgcaatatcggttattC ATTGATTttgccttgatttcTATTATAGAATGTTTGTATAcgcttacgtttgaagcaa c" /listShort="S744, dhaS, sqhC" /listLong="sodF" /label="promotor_-35" upshifts 1931048 /Source="Nicolas_upshifts" /id="U1575" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.59040959040959" /psig="0.96103896103896" /xcortree=509 /SigmaFactorBS="attgtagcttttttcttttgtaaattgcaatatcggttattC ATTGATTttgccttgatttcTATTATAGAATGTTTGTATAcgcttacgtttgaagcaa c" /listShort="S744, dhaS, sqhC" /listLong="sodF" /label="upshifts" misc_feature complement(1931050..1931062) /Source="Nicolas_upshift_promotors" /id="U1576" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.406593406593407" /psig="0.460539460539461" /xcortree=1224 /SigmaFactorBS="atagcacattgattcctggattgaatagcagaaataagctgt gatagttgcttcaaacgtaagcgtatacaaACATTCTATAATAgaaatcaaggcaaaa t" /listShort="S743, yozC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 1931050..1931069 /Source="Nicolas_upshift_promotors" /id="U1575" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.59040959040959" /psig="0.96103896103896" /xcortree=509 /SigmaFactorBS="attgtagcttttttcttttgtaaattgcaatatcggttattC ATTGATTttgccttgatttcTATTATAGAATGTTTGTATAcgcttacgtttgaagcaa c" /listShort="S744, dhaS, sqhC" /listLong="sodF" /label="promotor_-10" S_feature 1931053..1931185 /Source="Nicolas_S_feature" /locus_tag="new_2100447_2100579" /HighExp="BC, M0t90, M9-stat, S2, T2.30H, Sw, Lbstat, M40t90, T4.0H, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.961" /TUlongSig="NA" /TUlongPSig="NA" /label="S744" upshifts complement(1931074) /Source="Nicolas_upshifts" /id="U1576" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.406593406593407" /psig="0.460539460539461" /xcortree=1224 /SigmaFactorBS="atagcacattgattcctggattgaatagcagaaataagctgt gatagttgcttcaaacgtaagcgtatacaaACATTCTATAATAgaaatcaaggcaaaa t" /listShort="S743, yozC" /GFF_Attribute="listLong" /label="upshifts" CDS 1931186..1932673 /gene="dhaS" /locus_tag="BSU_19310" /old_locus_tag="BSU19310" /EC_number="1.2.1.3" /function="16.11: Scavenge (Catabolism)" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:17555270, 23874669, 25409630, 26337367, 27797724" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17555270, 23874669, 25409630, 26337367, 27797724; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-hydroxypropionaldehyde dehydrogenase" /protein_id="NP_389813.1" /db_xref="EnsemblGenomes-Gn:BSU19310" /db_xref="EnsemblGenomes-Tr:CAB13823" /db_xref="GOA:O34660" /db_xref="InterPro:IPR012394" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="SubtiList:BG12582" /db_xref="UniProtKB/Swiss-Prot:O34660" /translation="MSSLTMQVTKRLETFLQGTKKLYIDGKFVPSASGATFDTPNPAT GETLMTLYEAQAADVDKAVKAARKAFDQGEWRTMSPASRSRLMYKLADLMEEHKTELA QLETLDNGKPINETTNGDIPLAIEHMRYYAGWCTKITGQTIPVSGAYFNYTRHEPVGV VGQIIPWNFPLLMAMWKMGAALATGCTIVLKPAEQTPLSALYLAELIDQAGFPAGVIN IIPGFGEDAGEALTNHEAVDKIAFTGSTEIGKKIMSTAAKSIKRVTLELGGKSPNILL PDANLKKAIPGALNGVMFNQGQVCCAGSRVFIHKDQYDEVVDEMASYAESLRQGAGLH KDTQIGPLVSKEQHERVLSYIQKGKDEGAKAVTGGSCPFEAGYFVAPTVFANVEDEMT IAKEEIFGPVLTAIPYETVDEVIERANHSEYGLAAGLWTENVKQAHYIADRLQAGTVW VNCYNVFDAASPFGGYKQSGLGREMGSYALDNYTEVKSVWVNLED*" /label="dhaS CDS" gene 1931186..1932673 /gene="dhaS" /locus_tag="BSU_19310" /old_locus_tag="BSU19310" /label="dhaS gene" promotor_-10 complement(1931629..1931646) /Source="Nicolas_upshift_promotors" /id="U1577" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.526473526473527" /psig="0.526473526473527" /xcortree=656 /SigmaFactorBS="cgggaaattccatggaatgatctggccgACGACACCGacagg ctcatgaCGCGTATAATTAAAATAAgcgccggaaaccggaatcgtctgtcctgttatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1931635) /Source="Nicolas_upshifts" /id="U1577" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.526473526473527" /psig="0.526473526473527" /xcortree=656 /SigmaFactorBS="cgggaaattccatggaatgatctggccgACGACACCGacagg ctcatgaCGCGTATAATTAAAATAAgcgccggaaaccggaatcgtctgtcctgttatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1931659..1931667) /Source="Nicolas_upshift_promotors" /id="U1577" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.526473526473527" /psig="0.526473526473527" /xcortree=656 /SigmaFactorBS="cgggaaattccatggaatgatctggccgACGACACCGacagg ctcatgaCGCGTATAATTAAAATAAgcgccggaaaccggaatcgtctgtcctgttatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1932659 /Source="Nicolas_upshifts" /id="D1065" /incds=0 /nref=163 /ntot=260 /MaxReadThrough="3.66831" /MaxDrop="7.01026" /score="24.6079855" /energy="-7.1" /TU="U1575" /idTUdmin="U1575" /TUdmin="-1144" /isTUend="FALSE" /label="downshifts" promotor_-35 1932721..1932726 /Source="Nicolas_upshift_promotors" /id="U1578" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=1130 /SigmaFactorBS="aaaactgctgcctgccagcagtttttttctttctGTAATGgc agtaaaagacgctGAATATATATGCTTCTGAAggagttgagcgtgatgggcacacttc a" /listShort="sqhC, sodF, S745" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1932742..1932760 /Source="Nicolas_upshift_promotors" /id="U1578" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=1130 /SigmaFactorBS="aaaactgctgcctgccagcagtttttttctttctGTAATGgc agtaaaagacgctGAATATATATGCTTCTGAAggagttgagcgtgatgggcacacttc a" /listShort="sqhC, sodF, S745" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1932747 /Source="Nicolas_upshifts" /id="U1578" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.988011988011988" /psig="0.988011988011988" /xcortree=1130 /SigmaFactorBS="aaaactgctgcctgccagcagtttttttctttctGTAATGgc agtaaaagacgctGAATATATATGCTTCTGAAggagttgagcgtgatgggcacacttc a" /listShort="sqhC, sodF, S745" /GFF_Attribute="listLong" /label="upshifts" CDS 1932774..1934672 /gene="sqhC" /locus_tag="BSU_19320" /old_locus_tag="BSU19320" /EC_number="4.2.1.137" /EC_number="5.4.99.17" /function="16.13: Shape" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2253626, 18436644, 18630919, 21627333" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2253626, 18436644, 18630919, 21627333; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="squalene-hopene cyclase, sporulenol synthase (spore protection)" /protein_id="NP_389814.2" /db_xref="EnsemblGenomes-Gn:BSU19320" /db_xref="EnsemblGenomes-Tr:CAB13824" /db_xref="GOA:Q796C3" /db_xref="InterPro:IPR008930" /db_xref="InterPro:IPR018333" /db_xref="InterPro:IPR032696" /db_xref="InterPro:IPR032697" /db_xref="SubtiList:BG12679" /db_xref="UniProtKB/Swiss-Prot:Q796C3" /translation="MGTLQEKVRRFQKKTITELRDRQNADGSWTFCFEGPIMTNSFFI LLLTSLDEGENEKELISSLAAGIHAKQQPDGTFINYPDETRGNLTATVQGYVGMLASG CFHRTEPHMKKAEQFIISHGGLRHVHFMTKWMLAANGLYPWPALYLPLSLMALPPTLP IHFYQFSSYARIHFAPMAVTLNQRFVLINRNISSLHHLDPHMTKNPFTWLRSDAFEER DLTSILLHWKRVFHAPFAFQQLGLQTAKTYMLDRIEKDGTLYSYASATIYMVYSLLSL GVSRYSPIIRRAITGIKSLVTKCNGIPYLENSTSTVWDTALISYALQKNGVTETDGSV TKAADFLLERQHTKIADWSVKNPNSVPGGWGFSNINTNNPDCDDTTAVLKAIPRNHSP AAWERGVSWLLSMQNNDGGFSAFEKNVNHPLIRLLPLESAEDAAVDPSTADLTGRVLH FLGEKVGFTEKHQHIQRAVKWLFEHQEQNGSWYGRWGVCYIYGTWAALTGMHACGVDR KHPGIQKALRWLKSIQNDDGSWGESCKSAEIKTYVPLHRGTIVQTAWALDALLTYENS EHPSVVKGMQYLTDSSSHSADSLAYPAGIGLPKQFYIRYHSYPYVFSLLAVGKYLDSI EKETANET*" /label="sqhC CDS" gene 1932774..1934672 /gene="sqhC" /locus_tag="BSU_19320" /old_locus_tag="BSU19320" /label="sqhC gene" promotor_-10 complement(1933717..1933736) /Source="Nicolas_upshift_promotors" /id="U1579" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1383 /SigmaFactorBS="ctgcttttgtaacagagccatccgttTCGGTCACACcatttt tttgaagGGCATAGCTTATTAAAGCTGtatcccaaacagttgaagtagagttttccag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1933725) /Source="Nicolas_upshifts" /id="U1579" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1383 /SigmaFactorBS="ctgcttttgtaacagagccatccgttTCGGTCACACcatttt tttgaagGGCATAGCTTATTAAAGCTGtatcccaaacagttgaagtagagttttccag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1933750..1933759) /Source="Nicolas_upshift_promotors" /id="U1579" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1383 /SigmaFactorBS="ctgcttttgtaacagagccatccgttTCGGTCACACcatttt tttgaagGGCATAGCTTATTAAAGCTGtatcccaaacagttgaagtagagttttccag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1934662..1935507 /gene="sodF" /locus_tag="BSU_19330" /old_locus_tag="BSU19330" /EC_number="1.15.1.1" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 17114254, 20233928; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="superoxide dismutase (Fe2+-dependent)" /protein_id="NP_389815.1" /db_xref="EnsemblGenomes-Gn:BSU19330" /db_xref="EnsemblGenomes-Tr:CAB13825" /db_xref="GOA:O35023" /db_xref="InterPro:IPR001189" /db_xref="InterPro:IPR019831" /db_xref="InterPro:IPR019832" /db_xref="InterPro:IPR019833" /db_xref="InterPro:IPR036314" /db_xref="InterPro:IPR036324" /db_xref="SubtiList:BG12676" /db_xref="UniProtKB/Swiss-Prot:O35023" /translation="MKRESYQAEMFNWCEALKDQIQKRGQLDQFEDQIDKMIEALEDD QTTEEDWYKQAAALYRDITESDDTSERRAYVPIGKHVLPKLPYKYSALEPYISRDIMI LHHTKHHQSYVDGLNKAESELKKARATKNYDLITHWERELAFHGAGHYLHSIFWFSMH PNGKRRPTGALFQMIDLSFGSYSAFKEHFTQASKKVEGVGWAILVWAPRSGRLEILTA EKHQLFSQWDVIPLLPLDVWEHAYYLQYKNDRASYVDHWWNVVDWREAEKRFEQAKEV VWKLY*" /label="sodF CDS" gene 1934662..1935507 /gene="sodF" /locus_tag="BSU_19330" /old_locus_tag="BSU19330" /label="sodF gene" S_feature 1935508..1937014 /Source="Nicolas_S_feature" /locus_tag="new_2104902_2106408" /HighExp="S5, S6, S4, S8, S3, S7, T5.0H, B36, BT, T4.0H" /AntisenseName="yocR" /AntisenseCor="-0.62866346519731298" /AntisenseRegPval="-30.3" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S745" CDS complement(1935540..1936877) /gene="yocR" /locus_tag="BSU_19340" /old_locus_tag="BSU19340" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 17114254, 27766092; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative sodium-dependent transporter" /protein_id="NP_389816.1" /db_xref="EnsemblGenomes-Gn:BSU19340" /db_xref="EnsemblGenomes-Tr:CAB13826" /db_xref="GOA:O34383" /db_xref="InterPro:IPR000175" /db_xref="SubtiList:BG13528" /db_xref="UniProtKB/Swiss-Prot:O34383" /translation="MKEANQWSSKLGFILAAAGSAIGLGAIWKFPYVAGTSGGGAFLL IFILFTVLIGLPLLLGEFIIGRRTQKDAVQSYKTLAPGTKWHWIGYLGMVTCFILLSF YSVVGGWILIYIIKGFTGGLSQTSGFDTIFASTISNPYLAVGGQLLFMVVTILVVAKG VSSGIEKASQVLMPALFLLFIILMVRSVTLDGAMEGIKFFLMPDLTAIDANTILYAMG QSFFLLSVGVSVMVTYSAYLEKQENLVQSAVSVTVMNMLVAVMAGIAIFPAVFSFGLK PDQGPVLLFNVLPTVFNQMPFGIIFLLAFLLLFLFAALTSAFSMLEILVAVLSKGDIN KRKRFAWLGGIAIFIVGVPSALSYGVLSDVTIFHLSIFDAADYLVSNILMPLGALLIS IFVPLKIPKQDLFDELKSGSNLKRKWFAVWLLLIRYLSPVAIIIVFLHVIGIF*" /label="yocR CDS" gene complement(1935540..1936877) /gene="yocR" /locus_tag="BSU_19340" /old_locus_tag="BSU19340" /label="yocR gene" downshifts complement(1935551) /Source="Nicolas_upshifts" /id="D1066" /incds=0 /nref=1 /ntot=50 /MaxReadThrough="0.83968" /MaxDrop="2.44824" /score="27.8372036" /energy="-11.1" /TU="NA" /idTUdmin="U1580" /TUdmin=154 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1936905..1936924) /Source="Nicolas_upshift_promotors" /id="U1580" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2402 /SigmaFactorBS="tctatagatatatgatgtaaactaattaaaatgtTCTTGACT atataggaagatatTCTTACAATGAACCTTTATAatggttagatcaaataggagtgat a" /listShort="yocR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1936920) /Source="Nicolas_upshifts" /id="U1580" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2402 /SigmaFactorBS="tctatagatatatgatgtaaactaattaaaatgtTCTTGACT atataggaagatatTCTTACAATGAACCTTTATAatggttagatcaaataggagtgat a" /listShort="yocR" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1936922..1938080) /Source="Nicolas_S_feature" /locus_tag="new_2106316_2107474_c" /HighExp="M9-stat, T1.30H, B60, T1.0H, T2.0H, T0.30H, T2.30H, T3.0H, T3.30H, Etha" /AntisenseName="yocS" /AntisenseCor="-6.3575129468026695E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S746" promotor_-35 complement(1936939..1936946) /Source="Nicolas_upshift_promotors" /id="U1580" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2402 /SigmaFactorBS="tctatagatatatgatgtaaactaattaaaatgtTCTTGACT atataggaagatatTCTTACAATGAACCTTTATAatggttagatcaaataggagtgat a" /listShort="yocR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1936998..1937001 /Source="Nicolas_upshift_promotors" /id="U1581" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.611388611388611" /psig=1 /xcortree=2909 /SigmaFactorBS="ttagtttacatcatatatctatagacatctgccaaaaactaa TATTgaattattcagaaaATTATTTATAATAAGAGAATgttatgaaatttgtaagaat t" /listShort="yocS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1937016..1937035 /Source="Nicolas_upshift_promotors" /id="U1581" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.611388611388611" /psig=1 /xcortree=2909 /SigmaFactorBS="ttagtttacatcatatatctatagacatctgccaaaaactaa TATTgaattattcagaaaATTATTTATAATAAGAGAATgttatgaaatttgtaagaat t" /listShort="yocS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1937016 /Source="Nicolas_upshifts" /id="U1581" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.611388611388611" /psig=1 /xcortree=2909 /SigmaFactorBS="ttagtttacatcatatatctatagacatctgccaaaaactaa TATTgaattattcagaaaATTATTTATAATAAGAGAATgttatgaaatttgtaagaat t" /listShort="yocS" /GFF_Attribute="listLong" /label="upshifts" CDS 1937096..1938061 /gene="yocS" /locus_tag="BSU_19350" /old_locus_tag="BSU19350" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 27766092; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative sodium-dependent symporter" /protein_id="NP_389817.1" /db_xref="EnsemblGenomes-Gn:BSU19350" /db_xref="EnsemblGenomes-Tr:CAB13827" /db_xref="GOA:O34524" /db_xref="InterPro:IPR002657" /db_xref="InterPro:IPR004710" /db_xref="SubtiList:BG13529" /db_xref="UniProtKB/Swiss-Prot:O34524" /translation="MDIIRKISHFAGQTFGIWVIVFAVLGFSFPSLFTWISSYITIFL GIIMFGMGLTLQADDFKELVRKPWQVIIGVIAQYTIMPLVAFGLAFGLHLPAEIAVGV ILVGCCPGGTASNVMTFLAKGNTALSVAVTTISTLLAPVVTPLLIMLFAKEWLPVSPG SLFISILQAVLFPIIAGLIVKMFFRKQVAKAVHALPLVSVIGIVAIVSAVVSGNRENL LQSGLLIFSVVILHNGIGYLLGFLCAKLLKMDYPSQKAIAIEVGMQNSGLGAALATAH FSPLSAVPSAIFSVWHNLSGSMLATYWSKKVKKKQAGSKSSNLSL*" /label="yocS CDS" gene 1937096..1938061 /gene="yocS" /locus_tag="BSU_19350" /old_locus_tag="BSU19350" /label="yocS gene" downshifts 1938049 /Source="Nicolas_upshifts" /id="D1067" /incds=0 /nref=42 /ntot=166 /MaxReadThrough="3.53218" /MaxDrop="5.09676" /score="30.279305" /energy="-16.4" /TU="U1581" /idTUdmin="U1581" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(1938111..1939364) /gene="odhB" /locus_tag="BSU_19360" /old_locus_tag="BSU19360" /EC_number="2.3.1.61" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1508153, 2500417, 22720735, 26098117" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1508153, 2500417, 22720735, 26098117; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-oxoglutarate dehydrogenase complex (dihydrolipoamide transsuccinylase, E2 subunit)" /protein_id="NP_389818.2" /db_xref="EnsemblGenomes-Gn:BSU19360" /db_xref="EnsemblGenomes-Tr:CAB13828" /db_xref="GOA:P16263" /db_xref="InterPro:IPR000089" /db_xref="InterPro:IPR001078" /db_xref="InterPro:IPR003016" /db_xref="InterPro:IPR004167" /db_xref="InterPro:IPR006255" /db_xref="InterPro:IPR011053" /db_xref="InterPro:IPR036625" /db_xref="SubtiList:BG10273" /db_xref="UniProtKB/Swiss-Prot:P16263" /translation="MAEIKVPELAESISEGTIAQWLKQPGDYVEQGEYLLELETDKVN VELTAEESGVLQEVLKDSGDTVQVGEIIGTISEGAGESSAPAPTEKTESKESVKEEKQ AEPAAQEVSEEAQSEAKSRTIASPSARKLAREKGIDLSQVPTGDPLGRVRKQDVEAYE KPASKPAPQQKQQPQAQKAQQSFDKPVEVQKMSRRRQTIAKRLVEVQQTSAMLTTFNE VDMTAVMNLRKRRKDQFFEQNEVKLGFMSFFTKAVVAALKKYPLLNAEIQGDELIVKK FYDIGIAVAADEGLVVPVVRDADRLTFAGIEKEIGELAKKARNNKLTLSELQGGSFTI TNGGTFGSLMSTPILNSPQVGILGMHKIQLRPVAIDEERFENRPMMYIALSYDHRIVD GKEAVGFLVTIKNLLEDPEQLLLEG*" /label="odhB CDS" gene complement(1938111..1939364) /gene="odhB" /locus_tag="BSU_19360" /old_locus_tag="BSU19360" /label="odhB gene" downshifts complement(1938125) /Source="Nicolas_upshifts" /id="D1068" /incds=0 /nref=200 /ntot=253 /MaxReadThrough="5.25481" /MaxDrop="7.42366" /score="11.7726103" /energy="-16.4" /TU="U1582" /idTUdmin="U1582" /TUdmin="-1694" /isTUend="FALSE" /label="downshifts" CDS complement(1939380..1942214) /gene="odhA" /locus_tag="BSU_19370" /old_locus_tag="BSU19370" /EC_number="1.2.4.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1508153, 2500417" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1508153, 2500417; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-oxoglutarate dehydrogenase (E1 subunit)" /protein_id="NP_389819.3" /db_xref="EnsemblGenomes-Gn:BSU19370" /db_xref="EnsemblGenomes-Tr:CAB13829" /db_xref="GOA:P23129" /db_xref="InterPro:IPR001017" /db_xref="InterPro:IPR005475" /db_xref="InterPro:IPR011603" /db_xref="InterPro:IPR023784" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR031717" /db_xref="InterPro:IPR032106" /db_xref="SubtiList:BG10272" /db_xref="UniProtKB/Swiss-Prot:P23129" /translation="MFQNSMKQRMNWEDFYGPNLGYALELYDQYTQDPNSIDPDLKEM FDELGAPPSDIKEASGTKEKGRVTADLIQKIASAVRLAEDIRTYGHLNASVNPLRKDE KKSELFPLSDYGLTEEEIKAIPASVICKDAPKNISNGLEAIQYLRNTYKRTISFEFDH VHDFKEREWLTRKIESGELFQKNSAEKLSAVLERLTEVEGFEQFLHRTFVGQKRFSIE GLDALVPVLDDIIAQSVKSGTTSVNIGMAHRGRLNVLAHVLGKPYEIIFSEFQHAPNK DLVPSEGSIGISYGWTGDVKYHLGANRELQDAETKSARITLANNPSHLEFINPIVEGS TRAAQETRTQSGYPVQDETKSLAILIHGDAAFPGEGIVAETLNLSSLKGYQVGGAIHI IANNMIGFTTESAESRSTKYASDLAKGYEIPIVHVNADDPEACLSAVKFAVEYRKTFN KDFLIDLIGYRRYGHNEMDEPSTTQPMLYDAVRKHPTVKQIFAEKLVKEGVVTEEVVQ NIEKSVTKRIEDAYQKVPSKKEHTACEIELPEPVSNGFPDVDTSIDFDVLRKLNGELI NWPESFNVFGKLKRILERRAKAFDDDRKVEWSLAESLAFASILKDGTPIRLTGQDSER GTFAQRNLVLHDSETGKEFVPLHHLSDCSTSFAVHNSPLSEGSVLGFEYGYNVHSPET LVLWEAQYGDFANAAQVYFDQFISAGRAKWGQKSGLVMLLPHGYEGQGPEHSSGRIER FLQLAAENNWTVANLTSAAQYFHILRRQAKMLLREEIRPLVIMTPKSLLRNPNTVSEV QELSESRFQPVYEQSGLSHDYEKVTRLVLSSGKVSIDISDHFNKLEDGKEWLHIARIE QLYPFPAKGVKELFAKLPNLKEIVWVQEEPQNMGAWGYISPYLTEIAPEGVSVQYIGR RRRSSPAEGDPTVHKKEQERIVSDSLTRKN*" /label="odhA CDS" gene complement(1939380..1942214) /gene="odhA" /locus_tag="BSU_19370" /old_locus_tag="BSU19370" /label="odhA gene" promotor_-10 complement(1942309..1942328) /Source="Nicolas_upshift_promotors" /id="U1582" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.718281718281718" /psig=1 /xcortree=2228 /SigmaFactorBS="tataaaggttttttactattttgtgaacaatcaaGGTAGAAT caaattgcaaacagTGGTAAAATATCGTTGGAAGcgtttttattacataattttggac a" /listShort="odhA, odhB, S746, yocR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1942324) /Source="Nicolas_upshifts" /id="U1582" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.718281718281718" /psig=1 /xcortree=2228 /SigmaFactorBS="tataaaggttttttactattttgtgaacaatcaaGGTAGAAT caaattgcaaacagTGGTAAAATATCGTTGGAAGcgtttttattacataattttggac a" /listShort="odhA, odhB, S746, yocR" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1942326..1942442) /Source="Nicolas_S_feature" /locus_tag="new_2111720_2111836_c" /HighExp="dia15, G150, G135, H2O2, Lbexp, dia0, Oxctl, LBGtran, G180, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S747" promotor_-35 complement(1942343..1942350) /Source="Nicolas_upshift_promotors" /id="U1582" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.718281718281718" /psig=1 /xcortree=2228 /SigmaFactorBS="tataaaggttttttactattttgtgaacaatcaaGGTAGAAT caaattgcaaacagTGGTAAAATATCGTTGGAAGcgtttttattacataattttggac a" /listShort="odhA, odhB, S746, yocR" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1942443..1944359) /gene="yojO" /locus_tag="BSU_19380" /old_locus_tag="BSU19380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23087684; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative activator of nitric oxide reductase" /protein_id="NP_389820.2" /db_xref="EnsemblGenomes-Gn:BSU19380" /db_xref="EnsemblGenomes-Tr:CAB13830" /db_xref="InterPro:IPR002035" /db_xref="InterPro:IPR036465" /db_xref="SubtiList:BG13567" /db_xref="UniProtKB/Swiss-Prot:O31849" /translation="MKFIKFNDSTIDSFLFMMLTDLAKTLTKSEAVEVEYGVQSYYNP FEKKIYMSHFWKDRAAEDMEAGLKSDVYLRSVGTRYSSLHEFANFLNDIHRHLTFKSF AKQLFMLLEDIRIEECIKRERPGTKHVFAKRKDMYRKHFSTQLTLNLERSIFTDALFC AIYFKLTAESPLETLPSMREDIDLMRPFIEQQLLRVYEADSTRQVLKIVEDLMDGLEE VLDKDMLNTYFFLPELDYAKAAEQPLFEEEKKAPKLSDDITLPKQSDGDEDIHEEEMP TWHRETEAPSKSFLQFDIEHGAKSDLGKDASREGDDGDQALGSVQGSARQTKRKDYSK LEALESQKDQPNGAGMADGKENKYAFPIYKEPQPATSEEELSYKQQAKTIESYQKRLK QMIQKTLEHKKTLPRTDLHAGRLNNKLLRYFTERNPRLFYKKQEPSSEIDAVFTLLVD CSASMFDKMDETKRGIVLFHEALKSVAVPHQIVGFWEDTNDATEKSQPNYFNTVIPFQ SSLRQDSGPAIMQLEPEEDNRDGYAIRQMTKKMLHRSEAQKFLIVFSDGEPAAFGYEQ NGIVDTSEAVIEARKRGIEVINVFLSNSEIEESQMKTIQDMYGKFSIFVPDVDQLPDV LYPLLKKLLHKSIG*" /label="yojO CDS" gene complement(1942443..1944359) /gene="yojO" /locus_tag="BSU_19380" /old_locus_tag="BSU19380" /label="yojO gene" CDS complement(1944370..1945284) /gene="yojN" /locus_tag="BSU_19390" /old_locus_tag="BSU19390" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15491156, 23087684; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative nitric-oxide reductase associated protein" /protein_id="NP_389821.1" /db_xref="EnsemblGenomes-Gn:BSU19390" /db_xref="EnsemblGenomes-Tr:CAB13831" /db_xref="GOA:O31850" /db_xref="InterPro:IPR001270" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011704" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13566" /db_xref="UniProtKB/Swiss-Prot:O31850" /translation="MNRKGNLSMTTQLQHLTLPEDIQQKLLSYKEQPISPEFQSLIGT SGYEAEDEAILFDAIIALAMGKNVLLKGPTGSGKTKLAETLSSYFHKPMHSVNCSVDL DAEALVGYKTIENQSGQATIEFVSGPVTKAMKEGHFLYIDEINMAKPETLPILNGVLD YRKMMTNPFTGEVIRAKSGFGVIAAINEGYVGTVPLNEALKNRFVIIDVPYIKGELLK QVLMSQSALKDEKLIDRFITLSSDLIVQANNGQVSEEAASIRALIDTCDLAAYIPPRR AIERGIVEKLDDDREKAAVRNIAETLFE*" /label="yojN CDS" gene complement(1944370..1945284) /gene="yojN" /locus_tag="BSU_19390" /old_locus_tag="BSU19390" /label="yojN gene" promotor_-10 complement(1945288..1945307) /Source="Nicolas_upshift_promotors" /id="U1583" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1833 /SigmaFactorBS="taacgagaagcagtaatatcatccaggcccttttgTATTGag catacaggggctttTTTAGTATACTCGTTAATGGaatatgaataggaaagggaatctg t" /listShort="yojN, yojO, S747" /listLong="odhA, odhB, S746" /label="promotor_-10" upshifts complement(1945303) /Source="Nicolas_upshifts" /id="U1583" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1833 /SigmaFactorBS="taacgagaagcagtaatatcatccaggcccttttgTATTGag catacaggggctttTTTAGTATACTCGTTAATGGaatatgaataggaaagggaatctg t" /listShort="yojN, yojO, S747" /listLong="odhA, odhB, S746" /label="upshifts" promotor_-35 complement(1945324..1945328) /Source="Nicolas_upshift_promotors" /id="U1583" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1833 /SigmaFactorBS="taacgagaagcagtaatatcatccaggcccttttgTATTGag catacaggggctttTTTAGTATACTCGTTAATGGaatatgaataggaaagggaatctg t" /listShort="yojN, yojO, S747" /listLong="odhA, odhB, S746" /label="promotor_-35" CDS complement(1945348..1945938) /gene="sodC" /locus_tag="BSU_19400" /old_locus_tag="BSU19400" /EC_number="1.15.1.1" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15897454" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15897454; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="superoxide dismutase (exported lipoprotein)" /protein_id="NP_389822.1" /db_xref="EnsemblGenomes-Gn:BSU19400" /db_xref="EnsemblGenomes-Tr:CAB13832" /db_xref="GOA:O31851" /db_xref="InterPro:IPR001424" /db_xref="InterPro:IPR024134" /db_xref="InterPro:IPR036423" /db_xref="PDB:1S4I" /db_xref="PDB:1U3N" /db_xref="PDB:1XTL" /db_xref="PDB:1XTM" /db_xref="SubtiList:BG13565" /db_xref="UniProtKB/Swiss-Prot:O31851" /translation="MHRLLLLMMLTALGVAGCGQKKPPDPPNRVPEKKVVETSAFGHH VQLVNREGKAVGFIEIKESDDEGLDIHISANSLRPGASLGFHIYEKGSCVRPDFESAG GPFNPLNKEHGFNNPMGHHAGDLPNLEVGADGKVDVIMNAPDTSLKKGSKLNILDEDG SAFIIHEQADDYLTNPSGNSGARIVCGALLGNNEKQ*" /label="sodC CDS" gene complement(1945348..1945938) /gene="sodC" /locus_tag="BSU_19400" /old_locus_tag="BSU19400" /label="sodC gene" CDS complement(1946031..1947275) /gene="cwlS" /locus_tag="BSU_19410" /old_locus_tag="BSU19410" /EC_number="3.5.1.-" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16855244, 22139507" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16855244, 22139507; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peptidoglycan hydrolase (cell wall-binding d,l-endopeptidase)" /protein_id="NP_389823.1" /db_xref="EnsemblGenomes-Gn:BSU19410" /db_xref="EnsemblGenomes-Tr:CAB13833" /db_xref="GOA:O31852" /db_xref="InterPro:IPR000064" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG13564" /db_xref="UniProtKB/Swiss-Prot:O31852" /translation="MKKKIVAGLAVSAVVGSSMAAAPAEAKTIKVKSGDSLWKLSRQY DTTISALKSENKLKSTVLYVGQSLKVPESSKKSTTSPSNSSKTSTYTVAYGDSLWMIA KNHKMSVSELKSLNSLSSDLIRPGQKLKIKGTSSSSGSNGSKKNSGSNSSGSSKSTYT VKLGDSLWKIANSLNMTVAELKTLNGLTSDTLYPKQVLKIKGSSSPKNGNSGSKKPSN SNPSKTTTYKVKAGDSLWKIANRLGVTVQSIRDKNNLSSDVLQIGQVLTISGASKSNP SNPTKPTKPKDNSGSNIQIGSKIDRMITEAKKYVGVPYRWGGNTPAGFDCSGFIYYLI NNVSSISRLSTAGYWNVMQKVSQPSVGDFVFFTTYKSGPSHMGIYLGGGDFIHASSSG VDISNLSNSYWKQRYLGARSYF*" /label="cwlS CDS" gene complement(1946031..1947275) /gene="cwlS" /locus_tag="BSU_19410" /old_locus_tag="BSU19410" /label="cwlS gene" downshifts complement(1946033) /Source="Nicolas_upshifts" /id="D1069" /incds=0 /nref=20 /ntot=183 /MaxReadThrough="4.09529" /MaxDrop="3.77828" /score="11.0350171" /energy="-4.7" /TU="U1584,U1585" /idTUdmin="U1585" /TUdmin="-616" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1947338..1947356) /Source="Nicolas_upshift_promotors" /id="U1584" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=3048 /SigmaFactorBS="gatgctgaaaatgctgcgccaaatgtttgaaaaggGTTTAAC TtgctgaaaaattGACGATAAAACAGTTGTGTgccatttttggaaacaaaatactagc t" /listShort="cwlS, sodC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1947351) /Source="Nicolas_upshifts" /id="U1584" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=3048 /SigmaFactorBS="gatgctgaaaatgctgcgccaaatgtttgaaaaggGTTTAAC TtgctgaaaaattGACGATAAAACAGTTGTGTgccatttttggaaacaaaatactagc t" /listShort="cwlS, sodC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(1947353..1947573) /Source="Nicolas_S_feature" /locus_tag="new_2116747_2116967_c" /HighExp="S2, Lbstat, T2.30H, M0t90, HiOs, T3.0H, Etha, M40t90, T3.30H, SMMPr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S748" promotor_-35 complement(1947369..1947376) /Source="Nicolas_upshift_promotors" /id="U1584" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=3048 /SigmaFactorBS="gatgctgaaaatgctgcgccaaatgtttgaaaaggGTTTAAC TtgctgaaaaattGACGATAAAACAGTTGTGTgccatttttggaaacaaaatactagc t" /listShort="cwlS, sodC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1947559..1947577) /Source="Nicolas_upshift_promotors" /id="U1585" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=541 /SigmaFactorBS="agaacaggctttttgccatttcataagaatgcagagGAAGGG ATTtgacacgccgaTAGAGAATTGATTAGAAAAatagacaagaaaggaggagaaactg c" /listShort="S748, cwlS, sodC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1947573) /Source="Nicolas_upshifts" /id="U1585" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=541 /SigmaFactorBS="agaacaggctttttgccatttcataagaatgcagagGAAGGG ATTtgacacgccgaTAGAGAATTGATTAGAAAAatagacaagaaaggaggagaaactg c" /listShort="S748, cwlS, sodC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1947589..1947597) /Source="Nicolas_upshift_promotors" /id="U1585" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=541 /SigmaFactorBS="agaacaggctttttgccatttcataagaatgcagagGAAGGG ATTtgacacgccgaTAGAGAATTGATTAGAAAAatagacaagaaaggaggagaaactg c" /listShort="S748, cwlS, sodC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1947657..1948874) /gene="yojK" /locus_tag="BSU_19420" /old_locus_tag="BSU19420" /EC_number="2.4.1.-" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative YDP-glycosyltransferase" /protein_id="NP_389824.2" /db_xref="EnsemblGenomes-Gn:BSU19420" /db_xref="EnsemblGenomes-Tr:CAB13834" /db_xref="GOA:O31853" /db_xref="InterPro:IPR002213" /db_xref="InterPro:IPR006326" /db_xref="SubtiList:BG13563" /db_xref="UniProtKB/Swiss-Prot:O31853" /translation="MANVLMIGFPGEGHINPSIGVMKELKSRGENITYYAVKEYKEKI TALDIEFREYHDFRGDYFGKNATGDEERDFTEMLCAFLKACKDIATHIYEEVKHESYD YVIYDHHLLAGKVIANMLKLPRFSLCTTFAMNEEFAKEMMGAYMKGSLEDSPHYESYQ QLAETLNADFQAEIKKPFDVFLADGDLTIVFTSRGFQPLAEQFGERYVFVGPSITERA GNNDFPFDQIDNENVLFISMGTIFNNQKQFFNQCLEVCKDFDGKVVLSIGKHIKTSEL NDIPENFIVRPYVPQLEILKRASLFVTHGGMNSTSEGLYFETPLVVIPMGGDQFVVAD QVEKVGAGKVIKKEELSESLLKETIQEVMNNRSYAEKAKEIGQSLKAAGGSKKAADSI LEAVKQKTQSANA*" /label="yojK CDS" gene complement(1947657..1948874) /gene="yojK" /locus_tag="BSU_19420" /old_locus_tag="BSU19420" /label="yojK gene" downshifts complement(1947683) /Source="Nicolas_upshifts" /id="D1070" /incds=0 /nref=14 /ntot=145 /MaxReadThrough="1.49168" /MaxDrop="4.07727" /score="9.41396656" /energy="-14.4" /TU="NA" /idTUdmin="U1586" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1948907..1948926) /Source="Nicolas_upshift_promotors" /id="U1586" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.498501498501498" /psig="0.994005994005994" /xcortree=2220 /SigmaFactorBS="atatatgatgaatattaattaagtgaaaTACTTTACctgttt atgcattTATAGTACCGTATAAAATATtacataaattctcaaaggaagggtgctgccg c" /listShort="yojK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1948915) /Source="Nicolas_upshifts" /id="U1586" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.498501498501498" /psig="0.994005994005994" /xcortree=2220 /SigmaFactorBS="atatatgatgaatattaattaagtgaaaTACTTTACctgttt atgcattTATAGTACCGTATAAAATATtacataaattctcaaaggaagggtgctgccg c" /listShort="yojK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1948940..1948947) /Source="Nicolas_upshift_promotors" /id="U1586" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.498501498501498" /psig="0.994005994005994" /xcortree=2220 /SigmaFactorBS="atatatgatgaatattaattaagtgaaaTACTTTACctgttt atgcattTATAGTACCGTATAAAATATtacataaattctcaaaggaagggtgctgccg c" /listShort="yojK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1949110..1949733) /gene="cdaS" /locus_tag="BSU_19430" /old_locus_tag="BSU19430" /EC_number="2.7.7.85" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:21566650, 23192352, 24939848, 27252699, 27790204, 28751888" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21566650, 23192352, 24939848, 27252699, 27790204, 28751888; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="spore diadenylate cyclase" /protein_id="NP_389825.3" /db_xref="EnsemblGenomes-Gn:BSU19430" /db_xref="EnsemblGenomes-Tr:CAB13835" /db_xref="GOA:O31854" /db_xref="InterPro:IPR003390" /db_xref="InterPro:IPR014046" /db_xref="InterPro:IPR019457" /db_xref="InterPro:IPR034693" /db_xref="InterPro:IPR036888" /db_xref="SubtiList:BG13562" /db_xref="UniProtKB/Swiss-Prot:O31854" /translation="MKAMRYEQISENAFKGKIQVYLEQILGDASLILKTLHEKDQCLL CELDDLGHVFQDMQGIASSFYLQSYIEEFTPAFIELAKAIKALSEHKHGALIVIERAD PVERFIQKGTSLHAEISSSLIESIFFPGNPLHDGALLVRENKLVSAANVLPLTTKEVD IHLGTRHRAALGMSGYTDALVLVVSEETGKMSFAKDGVLYPLISPRT*" /label="cdaS CDS" gene complement(1949110..1949733) /gene="cdaS" /locus_tag="BSU_19430" /old_locus_tag="BSU19430" /label="cdaS gene" S_feature complement(1949734..1949884) /Source="Nicolas_S_feature" /locus_tag="new_2119128_2119278_c" /HighExp="S8, S5, S7, S6, Etha, S4, M9-stat, S3, C30, Gly" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S749" promotor_-35 1949760..1949766 /Source="Nicolas_upshift_promotors" /id="U1587" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=898 /SigmaFactorBS="gctcatagcgcatagccttcatctcctgtttaaatttccaac ttttcaCGAATGCttatcttattgatGCACATTCTATTggtaaaggagggatgtaaag a" /listShort="S750, norM" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1949772 /Source="Nicolas_upshifts" /id="U1587" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=898 /SigmaFactorBS="gctcatagcgcatagccttcatctcctgtttaaatttccaac ttttcaCGAATGCttatcttattgatGCACATTCTATTggtaaaggagggatgtaaag a" /listShort="S750, norM" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1949780..1949791 /Source="Nicolas_upshift_promotors" /id="U1587" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=898 /SigmaFactorBS="gctcatagcgcatagccttcatctcctgtttaaatttccaac ttttcaCGAATGCttatcttattgatGCACATTCTATTggtaaaggagggatgtaaag a" /listShort="S750, norM" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 1949798..1949806 /Source="Nicolas_upshift_promotors" /id="U1588" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=539 /SigmaFactorBS="atcttattgatgcacattctattggtaaaGGAGGGATGtaaa gaatggaAATCGAAAGAATCATTCAGtatatttgcacctttttaggcgtgatttcgct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_no_box 1949814..1949914 /Source="Nicolas_upshift_promotors" /id="U1589" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.56043956043956" /psig="0.006993006993007" /xcortree=1480 /SigmaFactorBS="tggaaatcgaaagaatcattcagtatatttgcacctttttag gcgtgatttcgctttcttttatttatgcccaaatgtttagaaaaacgaaaccgacaaa a" /listShort="S750, norM" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-10 1949818..1949836 /Source="Nicolas_upshift_promotors" /id="U1588" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=539 /SigmaFactorBS="atcttattgatgcacattctattggtaaaGGAGGGATGtaaa gaatggaAATCGAAAGAATCATTCAGtatatttgcacctttttaggcgtgatttcgct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1949829 /Source="Nicolas_upshifts" /id="U1588" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=539 /SigmaFactorBS="atcttattgatgcacattctattggtaaaGGAGGGATGtaaa gaatggaAATCGAAAGAATCATTCAGtatatttgcacctttttaggcgtgatttcgct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1949867..1949885) /Source="Nicolas_upshift_promotors" /id="U1590" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=740 /SigmaFactorBS="aaaaagcaatgaacgccgggcctattctttttttgtcGGTTT CGtttttctaaacatttGGGCATAAATAAAAGAAAGcgaaatcacgcctaaaaaggtg c" /listShort="S749, yojJ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1949874..1949959 /Source="Nicolas_S_feature" /locus_tag="new_2119268_2119353" /HighExp="S8, S7, S4, S5, S6, BT, S3, T5.0H, S2, ferm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigGF" /TUshortPSig="0.00699, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S750" upshifts 1949874 /Source="Nicolas_upshifts" /id="U1589" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.56043956043956" /psig="0.006993006993007" /xcortree=1480 /SigmaFactorBS="tggaaatcgaaagaatcattcagtatatttgcacctttttag gcgtgatttcgctttcttttatttatgcccaaatgtttagaaaaacgaaaccgacaaa a" /listShort="S750, norM" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1949884) /Source="Nicolas_upshifts" /id="U1590" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=740 /SigmaFactorBS="aaaaagcaatgaacgccgggcctattctttttttgtcGGTTT CGtttttctaaacatttGGGCATAAATAAAAGAAAGcgaaatcacgcctaaaaaggtg c" /listShort="S749, yojJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1949901..1949907) /Source="Nicolas_upshift_promotors" /id="U1590" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=740 /SigmaFactorBS="aaaaagcaatgaacgccgggcctattctttttttgtcGGTTT CGtttttctaaacatttGGGCATAAATAAAAGAAAGcgaaatcacgcctaaaaaggtg c" /listShort="S749, yojJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1949935..1949942 /Source="Nicolas_upshift_promotors" /id="U1591" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.634365634365634" /psig=1 /xcortree=2408 /SigmaFactorBS="cgaaaccgacaaaaaaagaataggcccggcgttcATTGCTTT ttatacataaaaTGTTATAATTTCTCTCGTTAtgaaaaagaaacggagatcaatgtat g" /listShort="norM, rsbRC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1949955..1949974 /Source="Nicolas_upshift_promotors" /id="U1591" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.634365634365634" /psig=1 /xcortree=2408 /SigmaFactorBS="cgaaaccgacaaaaaaagaataggcccggcgttcATTGCTTT ttatacataaaaTGTTATAATTTCTCTCGTTAtgaaaaagaaacggagatcaatgtat g" /listShort="norM, rsbRC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1949961 /Source="Nicolas_upshifts" /id="U1591" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.634365634365634" /psig=1 /xcortree=2408 /SigmaFactorBS="cgaaaccgacaaaaaaagaataggcccggcgttcATTGCTTT ttatacataaaaTGTTATAATTTCTCTCGTTAtgaaaaagaaacggagatcaatgtat g" /listShort="norM, rsbRC" /GFF_Attribute="listLong" /label="upshifts" CDS 1949999..1951357 /gene="mdtK" /locus_tag="BSU_19440" /old_locus_tag="BSU19440" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14766544, 15849754, 15855508, 16850406, 16954325, 17114254; Product type t : transporter" /codon_start=1 /transl_table=11 /product="Na+-driven efflux MatE family protein" /protein_id="NP_389826.1" /db_xref="EnsemblGenomes-Gn:BSU19440" /db_xref="EnsemblGenomes-Tr:CAB13836" /db_xref="GOA:O31855" /db_xref="InterPro:IPR002528" /db_xref="SubtiList:BG13561" /db_xref="UniProtKB/Swiss-Prot:O31855" /translation="MKETQNAREKIKQLLHILIPIFITQAGLSLITFLDTVMSGKVSP ADLAGVAIGSSLWTPVYTGLAGILMAVTPIVAQLLGAEKKQKIPFTVLQAVYVAALLS IAVLVIGYAAVDLILGRLNLDIHVHQIAKHFLGFLSLGIFPLFVYTVLRSFIDSLGKT RVTMMITLSSLPINFVLNYVFIFGKFGMPALGGVGAGLASALTYWCICIISFFIIHKN APFSEYGIFLTMYKFSWKACKNLLKIGLPIGFAVFFETSIFAAVTLLMSHFHTVTIAS HQAAMNFASLLYMLPLSVSMALTIVVGFEAGAARFKDARSYSLIGIMMAIGFSLFTAA CILLFREQIAGMYTSDPDVLRLTQHFLIYALFFQLSDAVAAPIQGALRGYKDVNYTLA AAFVSYWVIGLPVGYMVGTFTSLGAFGYWIGLIAGLAAGAVGLFFRLAKLQKRYSQKQ HI*" /label="mdtK CDS" gene 1949999..1951357 /gene="mdtK" /locus_tag="BSU_19440" /old_locus_tag="BSU19440" /label="mdtK gene" promotor_-10 complement(1950341..1950352) /Source="Nicolas_upshift_promotors" /id="U1592" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=946 /SigmaFactorBS="aaagcctaaaaagtgtttagcaatctgatgcacgTGAATATc aaggttcaatcgGCCAAGAATAAGgtcaactgcagcatatccaatcactaaaacggcg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1950346) /Source="Nicolas_upshifts" /id="U1592" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=946 /SigmaFactorBS="aaagcctaaaaagtgtttagcaatctgatgcacgTGAATATc aaggttcaatcgGCCAAGAATAAGgtcaactgcagcatatccaatcactaaaacggcg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1950366..1950372) /Source="Nicolas_upshift_promotors" /id="U1592" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=946 /SigmaFactorBS="aaagcctaaaaagtgtttagcaatctgatgcacgTGAATATc aaggttcaatcgGCCAAGAATAAGgtcaactgcagcatatccaatcactaaaacggcg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1951373..1952221 /gene="rsbRC" /locus_tag="BSU_19450" /old_locus_tag="BSU19450" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15312768, 15583165, 17158665, 20935101, 22287516, 24599254" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15312768, 15583165, 17158665, 20935101, 22287516, 24599254; Product type f : factor" /codon_start=1 /transl_table=11 /product="co-antagonist of RsbT; component of the anxiosome (stressosome)" /protein_id="NP_389827.1" /db_xref="EnsemblGenomes-Gn:BSU19450" /db_xref="EnsemblGenomes-Tr:CAB13837" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR036513" /db_xref="SubtiList:BG13560" /db_xref="UniProtKB/Swiss-Prot:O31856" /translation="MAKNKKLFEYLSQHAETISSTWYETIEETDPNSIYASTDPVVIH NLKSQNLAFNYKINRIFIDDEDVYLPILKEWAFEVTQDQEHLKTPIHYIIREFVRVRD LYVSYVKEFVHLNQNTVKSEEAEDLYHALIKAFDLVIHIFIEEMYKNTSLQLQAQKDM ITELSAPVIVLFHSVGLLPLIGDIDTVRAKLIMENTLHQCAKKKVTQLYIDLSGVAVI DTMVAHQLFSLIEALRLIGVSSTLSGIRPEIAQTAVQLGLSFEGISLRSTLASAIASD LKLKKV*" /label="rsbRC CDS" gene 1951373..1952221 /gene="rsbRC" /locus_tag="BSU_19450" /old_locus_tag="BSU19450" /label="rsbRC gene" promotor_-10 complement(1951637..1951656) /Source="Nicolas_upshift_promotors" /id="U1593" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1361 /SigmaFactorBS="aattctttcacataagaaacatataaATCTCTCACtctgaca aactccCGAATAATATAGTGGATAGGagtttttaaatgctcttgatcctgtgtgactt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1951644) /Source="Nicolas_upshifts" /id="U1593" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1361 /SigmaFactorBS="aattctttcacataagaaacatataaATCTCTCACtctgaca aactccCGAATAATATAGTGGATAGGagtttttaaatgctcttgatcctgtgtgactt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1951670..1951678) /Source="Nicolas_upshift_promotors" /id="U1593" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1361 /SigmaFactorBS="aattctttcacataagaaacatataaATCTCTCACtctgaca aactccCGAATAATATAGTGGATAGGagtttttaaatgctcttgatcctgtgtgactt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1952184 /Source="Nicolas_upshifts" /id="D1071" /incds=0 /nref=10 /ntot=138 /MaxReadThrough="1.62054" /MaxDrop="3.13267" /score="12.3887642" /energy="-14" /TU="NA" /idTUdmin="U1591" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(1952216) /Source="Nicolas_upshifts" /id="D1072" /incds=0 /nref=1 /ntot=13 /MaxReadThrough="1.55562" /MaxDrop="4.60101" /score="23.8391861" /energy="-13.7" /TU="NA" /idTUdmin="U1594" /TUdmin=22 /isTUend="TRUE" /label="downshifts" CDS complement(1952247..1952912) /gene="bshBB" /locus_tag="BSU_19460" /old_locus_tag="BSU19460" /EC_number="3.5.1.-" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15136574, 20308541" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15136574, 20308541; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="malate N-acetylglucosamine deacetylase (second enzyme)" /protein_id="YP_054582.2" /db_xref="EnsemblGenomes-Gn:BSU19460" /db_xref="EnsemblGenomes-Tr:CAB13838" /db_xref="GOA:O31857" /db_xref="InterPro:IPR003737" /db_xref="InterPro:IPR023841" /db_xref="InterPro:IPR024078" /db_xref="SubtiList:BG13559" /db_xref="UniProtKB/Swiss-Prot:O31857" /translation="MKEHVLVILPHPDDESYGVAGLIALNRKKDIPVTYACATLGEMG RNMGDPFFANRETLPLLRKQELINACKEMDINDLRMLGLRDKTLEFEDDEYLADIMEE IIDDVKPSLIVTFYPGHGVHPDHDACGEAVIRALYRKKKEDRPRTICMAITRNREEVL GEADVVLDIKEVADIKMNALRAHRTQTEGMLRELEEKLKNNEPVMATWFEEEIYWTYQ WND*" /label="bshBB CDS" gene complement(1952247..1952912) /gene="bshBB" /locus_tag="BSU_19460" /old_locus_tag="BSU19460" /label="bshBB gene" downshifts complement(1952261) /Source="Nicolas_upshifts" /id="D1073" /incds=0 /nref=189 /ntot=251 /MaxReadThrough="3.68743" /MaxDrop="7.13247" /score="23.8391861" /energy="-13.7" /TU="U1594" /idTUdmin="U1596" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1952931..1953281) /gene="yojF" /locus_tag="BSU_19470" /old_locus_tag="BSU19470" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 20308541" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (bacillithiol synthesis operon)" /protein_id="NP_389829.1" /db_xref="EnsemblGenomes-Gn:BSU19470" /db_xref="EnsemblGenomes-Tr:CAB13839" /db_xref="InterPro:IPR014934" /db_xref="InterPro:IPR036492" /db_xref="PDB:1NJH" /db_xref="SubtiList:BG13558" /db_xref="UniProtKB/Swiss-Prot:O31858" /translation="MKAIIKEDVQASLERYADRPVYIHLETTTGSYSAHLNEKNMTVV AYIRNAKVTYHQAKIKGNGPYRVGLKTEEGWIYAEGLTEYTVDEENRLLMAGHLPGGK LAISLQISEKPFTV*" /label="yojF CDS" gene complement(1952931..1953281) /gene="yojF" /locus_tag="BSU_19470" /old_locus_tag="BSU19470" /label="yojF gene" CDS complement(1953278..1953556) /gene="yoyC" /locus_tag="BSU_19479" /old_locus_tag="BSU19479" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 20308541, 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097741.1" /db_xref="EnsemblGenomes-Gn:BSU19479" /db_xref="EnsemblGenomes-Tr:CAX52638" /db_xref="UniProtKB/Swiss-Prot:O68260" /translation="MDNDKEIVKAYASLWNNRSLAHDDAEAVAEAIDLELLDKRTHPR LRKPMLEKYFAAIQRIVNSQLEPAVKYQLVKLHTERAEYLKEERGEQS*" /label="yoyC CDS" gene complement(1953278..1953556) /gene="yoyC" /locus_tag="BSU_19479" /old_locus_tag="BSU19479" /label="yoyC gene" promotor_-10 complement(1953583..1953602) /Source="Nicolas_upshift_promotors" /id="U1594" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.512487512487512" /psig="0.94105894105894" /xcortree=2009 /SigmaFactorBS="gtggaaacgggcgtcaaaaagccattgaggcctttgGCTTTT CagctgatgcatataTTATGTATAATCATTTCATGtatgtaagacataaaggagcaag a" /listShort="yoyC, yojF, yojG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1953599) /Source="Nicolas_upshifts" /id="U1594" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.512487512487512" /psig="0.94105894105894" /xcortree=2009 /SigmaFactorBS="gtggaaacgggcgtcaaaaagccattgaggcctttgGCTTTT CagctgatgcatataTTATGTATAATCATTTCATGtatgtaagacataaaggagcaag a" /listShort="yoyC, yojF, yojG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1953617..1953623) /Source="Nicolas_upshift_promotors" /id="U1594" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.512487512487512" /psig="0.94105894105894" /xcortree=2009 /SigmaFactorBS="gtggaaacgggcgtcaaaaagccattgaggcctttgGCTTTT CagctgatgcatataTTATGTATAATCATTTCATGtatgtaagacataaaggagcaag a" /listShort="yoyC, yojF, yojG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1953632..1954528) /gene="yojE" /locus_tag="BSU_19480" /old_locus_tag="BSU19480" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22226636, 23944997; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative N-acetylated toxic metabolites" /protein_id="NP_389830.2" /db_xref="EnsemblGenomes-Gn:BSU19480" /db_xref="EnsemblGenomes-Tr:CAB13840" /db_xref="GOA:O31859" /db_xref="InterPro:IPR000620" /db_xref="InterPro:IPR004626" /db_xref="SubtiList:BG13557" /db_xref="UniProtKB/Swiss-Prot:O31859" /translation="MQHAETKKGVIYTAVSFIMWGLFPLYWKLLEQLPALDILAHRII WSFVFMCIVLFFLRQWKIGWQELRSLKKNGGILSLFLASILISINWFVYIWAVNHGFL LEASLGYYINPLVSVLLGILFLKEKLNRLQLVAVSIAAAGVIISAFQYGSIPYVALLL AFSFGLYGLSKKRTSLPSAIGLTLETFMIMPIALGYLLFSGHVQPAGAESGGTWLLLF LAGVFTALPLLLFAEGAKRLPLYQVGILQYIAPTITLLIGLFVYHEPFSSSKAFTFSC IWAALLLFTFSQVKWKRASKSH*" /label="yojE CDS" gene complement(1953632..1954528) /gene="yojE" /locus_tag="BSU_19480" /old_locus_tag="BSU19480" /label="yojE gene" promotor_-35 1954370..1954379 /Source="Nicolas_upshift_promotors" /id="U1595" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1337 /SigmaFactorBS="actcctgccatcctattttccattgccgcaagaaaaaaagTA CGATACACataaaaacaaaagACCATATAATACGATGAGCCaaaatatcaagagccgg c" /listShort="S751, gerT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1954390 /Source="Nicolas_upshifts" /id="U1595" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1337 /SigmaFactorBS="actcctgccatcctattttccattgccgcaagaaaaaaagTA CGATACACataaaaacaaaagACCATATAATACGATGAGCCaaaatatcaagagccgg c" /listShort="S751, gerT" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1954393..1954412 /Source="Nicolas_upshift_promotors" /id="U1595" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1337 /SigmaFactorBS="actcctgccatcctattttccattgccgcaagaaaaaaagTA CGATACACataaaaacaaaagACCATATAATACGATGAGCCaaaatatcaagagccgg c" /listShort="S751, gerT" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 1954408..1954626 /Source="Nicolas_S_feature" /locus_tag="new_2123802_2124020" /HighExp="S6, S8, S7, BT, S5, B36, G/S, Pyr, B60, SMMPr" /AntisenseName="yojE" /AntisenseCor="-0.562105310907978" /AntisenseRegPval="-23.1" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S751" promotor_-10 complement(1954552..1954571) /Source="Nicolas_upshift_promotors" /id="U1596" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.93006993006993" /psig=1 /xcortree=2446 /SigmaFactorBS="aaacattgtcttcacatcctttcttcacggacaaaatagtat ATGCCCACcagatctttcaCGTGATATAATATAAGATGCtctaaagaaaggcagggat a" /listShort="yojE, yoyC, yojF, yojG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1954572) /Source="Nicolas_upshifts" /id="U1596" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.93006993006993" /psig=1 /xcortree=2446 /SigmaFactorBS="aaacattgtcttcacatcctttcttcacggacaaaatagtat ATGCCCACcagatctttcaCGTGATATAATATAAGATGCtctaaagaaaggcagggat a" /listShort="yojE, yoyC, yojF, yojG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1954583..1954590) /Source="Nicolas_upshift_promotors" /id="U1596" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.93006993006993" /psig=1 /xcortree=2446 /SigmaFactorBS="aaacattgtcttcacatcctttcttcacggacaaaatagtat ATGCCCACcagatctttcaCGTGATATAATATAAGATGCtctaaagaaaggcagggat a" /listShort="yojE, yoyC, yojF, yojG" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1954627..1955100 /gene="gerT" /locus_tag="BSU_19490" /old_locus_tag="BSU19490" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:17720779" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17720779; Product type s: structure" /codon_start=1 /transl_table=11 /product="component of the spore coat" /protein_id="YP_054583.1" /db_xref="EnsemblGenomes-Gn:BSU19490" /db_xref="EnsemblGenomes-Tr:CAE01457" /db_xref="GOA:Q7WY67" /db_xref="InterPro:IPR008978" /db_xref="SubtiList:BG14190" /db_xref="UniProtKB/Swiss-Prot:Q7WY67" /translation="MFEWNKYFPFHNQFSKEALKKADPKEVETYVNRVMESVFGSDYA AQFPFRDPLPQKEHPAKPDAKPDVKPDIDIFETADHVFVKVPISEEWLEQVRIKHTSH ELWLENLPRADHPKKVNLPCLVKRKGTKAVYKDGLLEVMFQKQQDYNMSEVEIIR*" /label="gerT CDS" gene 1954627..1955100 /gene="gerT" /locus_tag="BSU_19490" /old_locus_tag="BSU19490" /label="gerT gene" downshifts 1955097 /Source="Nicolas_upshifts" /id="D1074" /incds=0 /nref=23 /ntot=53 /MaxReadThrough="-0.0703700000000005" /MaxDrop="9.27889" /score="40.8456275" /energy="-16.6" /TU="NA" /idTUdmin="U1595" /TUdmin=7 /isTUend="TRUE" /label="downshifts" CDS complement(1955135..1955371) /gene="yojB" /locus_tag="BSU_19510" /old_locus_tag="BSU19510" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389832.1" /db_xref="EnsemblGenomes-Gn:BSU19510" /db_xref="EnsemblGenomes-Tr:CAB13842" /db_xref="GOA:O31861" /db_xref="SubtiList:BG13555" /db_xref="UniProtKB/Swiss-Prot:O31861" /translation="MYPHHSYLRGIPGPAGYPARSPFLFGAPLVGGLLGGFLGSALFN YSRPYAYPPGPYGYGGGPYGFGAGVPYGGYPGFY*" /label="yojB CDS" gene complement(1955135..1955371) /gene="yojB" /locus_tag="BSU_19510" /old_locus_tag="BSU19510" /label="yojB gene" downshifts complement(1955143) /Source="Nicolas_upshifts" /id="D1075" /incds=0 /nref=37 /ntot=68 /MaxReadThrough="2.10188" /MaxDrop="7.8003" /score="35.4403926" /energy="-16.6" /TU="NA" /idTUdmin="U1597" /TUdmin=1 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1955394..1955413) /Source="Nicolas_upshift_promotors" /id="U1597" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1296 /SigmaFactorBS="ggcttgtgatgtaacaatcatagacagtccgtaGCCCAATCG TttttcttccttgcTGAATACTTTACGTATAGGCagacataaaggaggaaaaaatcat g" /listShort="yojB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1955409) /Source="Nicolas_upshifts" /id="U1597" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1296 /SigmaFactorBS="ggcttgtgatgtaacaatcatagacagtccgtaGCCCAATCG TttttcttccttgcTGAATACTTTACGTATAGGCagacataaaggaggaaaaaatcat g" /listShort="yojB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1955427..1955436) /Source="Nicolas_upshift_promotors" /id="U1597" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1296 /SigmaFactorBS="ggcttgtgatgtaacaatcatagacagtccgtaGCCCAATCG TttttcttccttgcTGAATACTTTACGTATAGGCagacataaaggaggaaaaaatcat g" /listShort="yojB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1955456..1956790) /gene="yojA" /locus_tag="BSU_19520" /old_locus_tag="BSU19520" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 3020045, 15849754, 16850406, 17114254; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative H+/anion permease" /protein_id="NP_389833.1" /db_xref="EnsemblGenomes-Gn:BSU19520" /db_xref="EnsemblGenomes-Tr:CAB13843" /db_xref="GOA:O31862" /db_xref="InterPro:IPR003474" /db_xref="SubtiList:BG13554" /db_xref="UniProtKB/Swiss-Prot:O31862" /translation="MPILIVAVGVLILLFLIIKVKLNTFVSLIVVSFLVAIGLGMDIN KIVLSIETGIGGQLGHLALVFGLGAMLGRLVSDAGGGYRIAITLIDKFGRKRIQAAVV VASFIIGIALFFEVGLVLLIPIVYAIAKELKMPFLYLGIPMAAALNVTHGFLPPHPAP TAISVAYGAHIGQVLLFGIIIAVPTTVIAGPLFNKFAMKRFPGAYQKHGNLSGLGPRK EFQLDETPGFAISAVTSLFPVIFMAMATIFSLLLSEHSKGKDIIEFIGTPGTAMLISL LLALYTMGYARKISMQEIGRSISESISQIAMMLLIIGGGGAFKQVLIDGGVGDYVADF FRQTNMSPLFVAWTIAAVLRLCLGSATVAALTTAGMAAPLMEAGSVNPALMVLATGAG SVIACHVNDAGFWMVKEFFGLSMKETFQTWTLLTTVLSVTGLGCVLLAGLVM*" /label="yojA CDS" gene complement(1955456..1956790) /gene="yojA" /locus_tag="BSU_19520" /old_locus_tag="BSU19520" /label="yojA gene" S_feature complement(1956791..1956926) /Source="Nicolas_S_feature" /locus_tag="new_2126185_2126320_c" /HighExp="M0t90, M40t90, Lbtran, S1, dia5, Mt0, T0.0H, BI, Lbstat, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.25781100000000001" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S752" promotor_-10 complement(1956923..1956942) /Source="Nicolas_upshift_promotors" /id="U1598" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=324 /SigmaFactorBS="gtaggtaatcgagacaagctcataaaaacGATTGACAgtcat tgattaggaGATTAGTATGAACATATTAGttgatcaaaagataacaatcatataacca a" /listShort="S752, yojA, yojB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1956933) /Source="Nicolas_upshifts" /id="U1598" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=324 /SigmaFactorBS="gtaggtaatcgagacaagctcataaaaacGATTGACAgtcat tgattaggaGATTAGTATGAACATATTAGttgatcaaaagataacaatcatataacca a" /listShort="S752, yojA, yojB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1956957..1956964) /Source="Nicolas_upshift_promotors" /id="U1598" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=324 /SigmaFactorBS="gtaggtaatcgagacaagctcataaaaacGATTGACAgtcat tgattaggaGATTAGTATGAACATATTAGttgatcaaaagataacaatcatataacca a" /listShort="S752, yojA, yojB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1957022..1957029 /Source="Nicolas_upshift_promotors" /id="U1599" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.638361638361638" /psig="0.996003996003996" /xcortree=2766 /SigmaFactorBS="tacctaccgcctaacccaatgatttattagttataTGTTGAT TaacttttggttataTGTTATGTTTTTTAAAGTTGactgccaatcattatatctctcc a" /listShort="S753, yodA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1957044..1957063 /Source="Nicolas_upshift_promotors" /id="U1599" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.638361638361638" /psig="0.996003996003996" /xcortree=2766 /SigmaFactorBS="tacctaccgcctaacccaatgatttattagttataTGTTGAT TaacttttggttataTGTTATGTTTTTTAAAGTTGactgccaatcattatatctctcc a" /listShort="S753, yodA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1957047 /Source="Nicolas_upshifts" /id="U1599" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.638361638361638" /psig="0.996003996003996" /xcortree=2766 /SigmaFactorBS="tacctaccgcctaacccaatgatttattagttataTGTTGAT TaacttttggttataTGTTATGTTTTTTAAAGTTGactgccaatcattatatctctcc a" /listShort="S753, yodA" /GFF_Attribute="listLong" /label="upshifts" S_feature 1957048..1957154 /Source="Nicolas_S_feature" /locus_tag="new_2126442_2126548" /HighExp="M0t90, M40t90, LoTm, Salt, Cold, BI, HPh, LBGstat, GM 60, GM 45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S753" CDS 1957155..1957544 /gene="yodA" /locus_tag="BSU_19530" /old_locus_tag="BSU19530" /EC_number="5.3.2.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative tautomerase" /protein_id="NP_389834.1" /db_xref="EnsemblGenomes-Gn:BSU19530" /db_xref="EnsemblGenomes-Tr:CAB13844" /db_xref="GOA:O34882" /db_xref="InterPro:IPR004370" /db_xref="InterPro:IPR014347" /db_xref="SubtiList:BG13530" /db_xref="UniProtKB/Swiss-Prot:O34882" /translation="MPLLRFDVIEGRDEKSLQLLLDTAHQAMVEAFGVPERDRYQIVH QHPANELIIQDAGLGFQRTKDMVIISMTSKARTESQKEKLYALLAERLEKKCEISPDD LMVSITENGDADWSFGLGEAQFLNGKL*" /label="yodA CDS" gene 1957155..1957544 /gene="yodA" /locus_tag="BSU_19530" /old_locus_tag="BSU19530" /label="yodA gene" downshifts 1957554 /Source="Nicolas_upshifts" /id="D1076" /incds=0 /nref=1 /ntot=8 /MaxReadThrough="1.20831" /MaxDrop="2.65754" /score="14.4455719" /energy="-13.2" /TU="NA" /idTUdmin="U1599" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1957951..1958289) /gene="arxR" /locus_tag="BSU_19540" /old_locus_tag="BSU19540" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17158660, 18208493, 20652907, 27531959" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17158660, 18208493, 20652907, 27531959; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor" /protein_id="NP_389835.1" /db_xref="EnsemblGenomes-Gn:BSU19540" /db_xref="EnsemblGenomes-Tr:CAB13845" /db_xref="GOA:O34844" /db_xref="InterPro:IPR002577" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:5HS7" /db_xref="PDB:5HS8" /db_xref="PDB:5HS9" /db_xref="SubtiList:BG13531" /db_xref="UniProtKB/Swiss-Prot:O34844" /translation="MGNTMCPKMESAFSLLGKRWNGLIIHVLMDGPKRFKEITETIPM ISQKMLAERLKELEQNEIVERQVLPETPVKVIYTLTEKGTALQAVFQEMQAWADQFCE PGDTVCEEEK*" /label="arxR CDS" gene complement(1957951..1958289) /gene="arxR" /locus_tag="BSU_19540" /old_locus_tag="BSU19540" /label="arxR gene" promotor_-35 1958312..1958319 /Source="Nicolas_upshift_promotors" /id="U1600" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.674325674325674" /psig=1 /xcortree=2349 /SigmaFactorBS="tttcccataagtcttcatcccttcatctatTGATTGACatgt attcaatgaTCCATTACAATAATCTTTCAagttacatttagtaagcttctaacttttc t" /listShort="S754, yodC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1958333..1958352 /Source="Nicolas_upshift_promotors" /id="U1600" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.674325674325674" /psig=1 /xcortree=2349 /SigmaFactorBS="tttcccataagtcttcatcccttcatctatTGATTGACatgt attcaatgaTCCATTACAATAATCTTTCAagttacatttagtaagcttctaacttttc t" /listShort="S754, yodC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1958342 /Source="Nicolas_upshifts" /id="U1600" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.674325674325674" /psig=1 /xcortree=2349 /SigmaFactorBS="tttcccataagtcttcatcccttcatctatTGATTGACatgt attcaatgaTCCATTACAATAATCTTTCAagttacatttagtaagcttctaacttttc t" /listShort="S754, yodC" /GFF_Attribute="listLong" /label="upshifts" S_feature 1958346..1958418 /Source="Nicolas_S_feature" /locus_tag="new_2127740_2127812" /HighExp="dia5, Diami, dia15, Salt, Lbtran, Heat, HiOs, S1, aero, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S754" promotor_-10 complement(1958377..1958396) /Source="Nicolas_upshift_promotors" /id="U1601" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.882117882117882" /psig="0.997002997002997" /xcortree=3124 /SigmaFactorBS="aaacatccagagtattcgtcatagtgTTTCCTCcttcggata aaCGTGGTATGATAATAGAAAAgttagaagcttactaaatgtaacttgaaagattatt g" /listShort="yodB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1958380) /Source="Nicolas_upshifts" /id="U1601" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.882117882117882" /psig="0.997002997002997" /xcortree=3124 /SigmaFactorBS="aaacatccagagtattcgtcatagtgTTTCCTCcttcggata aaCGTGGTATGATAATAGAAAAgttagaagcttactaaatgtaacttgaaagattatt g" /listShort="yodB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1958408..1958414) /Source="Nicolas_upshift_promotors" /id="U1601" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.882117882117882" /psig="0.997002997002997" /xcortree=3124 /SigmaFactorBS="aaacatccagagtattcgtcatagtgTTTCCTCcttcggata aaCGTGGTATGATAATAGAAAAgttagaagcttactaaatgtaacttgaaagattatt g" /listShort="yodB" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1958419..1959027 /gene="noxC" /locus_tag="BSU_19550" /old_locus_tag="BSU19550" /EC_number="1.6.99.3" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 21749987, 24525333, 26312069; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="water forming NADH oxidase (nitroreductase)" /protein_id="NP_389836.1" /db_xref="EnsemblGenomes-Gn:BSU19550" /db_xref="EnsemblGenomes-Tr:CAB13846" /db_xref="GOA:P81102" /db_xref="InterPro:IPR000415" /db_xref="InterPro:IPR029479" /db_xref="SubtiList:BG13532" /db_xref="UniProtKB/Swiss-Prot:P81102" /translation="MTNTLDVLKARASVKEYDTNAPISKEELTELLDLATKAPSAWNL QHWHFTVFHSDESKAELLPVAYNQKQIVESSAVVAILGDLKANENGEEVYAELASQGY ITDEIKQTLLGQINGAYQSEQFARDSAFLNASLAAMQLMIAAKAKGYDTCAIGGFNKE QFQKQFDISERYVPVMLISIGKAVKPAHQSNRLPLSKVSTWL*" /label="noxC CDS" gene 1958419..1959027 /gene="noxC" /locus_tag="BSU_19550" /old_locus_tag="BSU19550" /label="noxC gene" downshifts 1959017 /Source="Nicolas_upshifts" /id="D1077" /incds=0 /nref=98 /ntot=245 /MaxReadThrough="1.58009" /MaxDrop="5.56809" /score="28.8840715" /energy="-14.3" /TU="NA" /idTUdmin="U1600" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" CDS complement(1959070..1959672) /gene="yodD" /locus_tag="BSU_19560" /old_locus_tag="BSU19560" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17407181; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_389837.1" /db_xref="EnsemblGenomes-Gn:BSU19560" /db_xref="EnsemblGenomes-Tr:CAB13847" /db_xref="GOA:O34842" /db_xref="InterPro:IPR002925" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG13533" /db_xref="UniProtKB/Swiss-Prot:O34842" /translation="MKHIYEKGTSDNVLLLLHGTGGNEHDLLSLGRFIDPDAHLLGVR GSVLENGMPRFFKRLSEGVFDEKDLVVRTRELKDFIDEAAETHQFNRGRVIAVGYSNG ANIAASLLFHYKDVLKGAILHHPMVPIRGIELPDMAGLPVFIGAGKYDPLCTKEESEE LYRYLRDSGASASVYWQDGGHQLTQHEAEQAREWYKEAIV*" /label="yodD CDS" gene complement(1959070..1959672) /gene="yodD" /locus_tag="BSU_19560" /old_locus_tag="BSU19560" /label="yodD gene" CDS complement(1959688..1960599) /gene="yodE" /locus_tag="BSU_19570" /old_locus_tag="BSU19570" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10960106, 17407181, 19329649, 25720121; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative thiol-dependent lyase/dioxygenase" /protein_id="NP_389838.1" /db_xref="EnsemblGenomes-Gn:BSU19570" /db_xref="EnsemblGenomes-Tr:CAB13848" /db_xref="GOA:O34543" /db_xref="InterPro:IPR000595" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG13534" /db_xref="UniProtKB/Swiss-Prot:O34543" /translation="MKTEGLHHVTAFARDPQENLRFYTEVLGLRLVKKTVNFDDPGTY HFYFGNQNGDPGTIMTFFPFQGSGQGTVGKGQAGRVYFSVPSGSLSFWKERLEKSGLS LEEKTLFGEKGLIFDDTEDLPLAIMEDAKSGKSEWTPDGITTNEAITGMKGVLLYSYD PQATIQLLTESFGYTKVAEEDQIVRLASSAAVGGVIDVHLHPEKRGVGGYGTVHHVAF RTKKKEQAKWLPIIAENHLPSSEILDREYFTSVYFREKGGILFEIATDEPGFMTDETF AELGTSLKLPEWLEKHRQQITDILPEL*" /label="yodE CDS" gene complement(1959688..1960599) /gene="yodE" /locus_tag="BSU_19570" /old_locus_tag="BSU19570" /label="yodE gene" promotor_-10 complement(1960628..1960647) /Source="Nicolas_upshift_promotors" /id="U1602" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.317682317682318" /psig="0.997002997002997" /xcortree=3021 /SigmaFactorBS="aaatgattttttcaattatttaatcaaaacacatggTTTGCA tccttttcaataaagGTTTAAAATAATAAATATCTtgaaatcgagataaataggagtg a" /listShort="yodE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1960644) /Source="Nicolas_upshifts" /id="U1602" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.317682317682318" /psig="0.997002997002997" /xcortree=3021 /SigmaFactorBS="aaatgattttttcaattatttaatcaaaacacatggTTTGCA tccttttcaataaagGTTTAAAATAATAAATATCTtgaaatcgagataaataggagtg a" /listShort="yodE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1960663..1960668) /Source="Nicolas_upshift_promotors" /id="U1602" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.317682317682318" /psig="0.997002997002997" /xcortree=3021 /SigmaFactorBS="aaatgattttttcaattatttaatcaaaacacatggTTTGCA tccttttcaataaagGTTTAAAATAATAAATATCTtgaaatcgagataaataggagtg a" /listShort="yodE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1960720..1960723 /Source="Nicolas_upshift_promotors" /id="U1603" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2907 /SigmaFactorBS="gattaaataattgaaaaaatcatttttttctaataattatCT TGtgatcttttcttacAACTGCTATTATAGTGAGCAttatcatgtttcaggaggaaag t" /listShort="yoyD, yodF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1960738..1960757 /Source="Nicolas_upshift_promotors" /id="U1603" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2907 /SigmaFactorBS="gattaaataattgaaaaaatcatttttttctaataattatCT TGtgatcttttcttacAACTGCTATTATAGTGAGCAttatcatgtttcaggaggaaag t" /listShort="yoyD, yodF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1960740 /Source="Nicolas_upshifts" /id="U1603" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.576423576423576" /psig=1 /xcortree=2907 /SigmaFactorBS="gattaaataattgaaaaaatcatttttttctaataattatCT TGtgatcttttcttacAACTGCTATTATAGTGAGCAttatcatgtttcaggaggaaag t" /listShort="yoyD, yodF" /GFF_Attribute="listLong" /label="upshifts" CDS 1960783..1960983 /gene="yoyD" /locus_tag="BSU_19579" /old_locus_tag="BSU19579" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23504016, 24843172; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="YP_003097742.1" /db_xref="EnsemblGenomes-Gn:BSU19579" /db_xref="EnsemblGenomes-Tr:CAX52639" /db_xref="GOA:C0H431" /db_xref="InterPro:IPR021741" /db_xref="UniProtKB/Swiss-Prot:C0H431" /translation="MVKKALIVILILLPFVQLALLPLVNRIEPIMFGLPFFHFWLLLW IIVTPLCSFGIYQMQKKDGGLE*" /label="yoyD CDS" gene 1960783..1960983 /gene="yoyD" /locus_tag="BSU_19579" /old_locus_tag="BSU19579" /label="yoyD gene" CDS 1960983..1962473 /gene="yodF" /locus_tag="BSU_19580" /old_locus_tag="BSU19580" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12823818, 15849754, 16850406, 24142252, 27766092; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative Na+/metabolite permease" /protein_id="NP_389839.1" /db_xref="EnsemblGenomes-Gn:BSU19580" /db_xref="EnsemblGenomes-Tr:CAB13849" /db_xref="GOA:O34745" /db_xref="InterPro:IPR001734" /db_xref="SubtiList:BG13535" /db_xref="UniProtKB/Swiss-Prot:O34745" /translation="MQGNLTALLITAIIVLTVVCIGFLAGRDKSSRTSVEEWSVGGRR FGGLLVWFLVGADLYTAYTFLGLTSTAFTGGSVAFFAIPYSVLAYFIAYFFLPKLWKV AKIHKLTTLADYARERFNSKLLASLVAIVGVLMLIPYICLQLSGIQDTLQVAGTGYIN VKFVVIISFILVALYTFFSGIKGPTYTAIIKDILVWVIMLFMVVSLPLIHFNGWTPMI DTLVKEAPQMLTIPSEGPKGIPWFITASIVSALALFMWAHAATGVFTAKSADAVRKNS MFLPLYNIVLILVIFLGFIAFLVLPEDTNPRLALLHLIQTSYGGVAQGFAYATIALAS LIPCSIMAIGASNLFANNLYRDLIHPNVSQSKLTLVTRSMVFVVIGLALLFGMLFPTA LVTLQLLGVSGMVQIFPAIAVSLFWKNQTKEATVIGLLAGLAVTFIVYITQSAHGIYE GFWGLAANMIAVVILNPLFVKNAGSNPVIEGLFGKKQDANPNQKGA*" /label="yodF CDS" gene 1960983..1962473 /gene="yodF" /locus_tag="BSU_19580" /old_locus_tag="BSU19580" /label="yodF gene" promotor_-10 complement(1961718..1961729) /Source="Nicolas_upshift_promotors" /id="U1604" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=821 /SigmaFactorBS="ttcgccgtgaaaacacctgtagcggcatgtgccCACATAAaa agtgccagagcGGAAACAATAGAtgctgtgataaaccaaggaatgccttttggccctt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1961722) /Source="Nicolas_upshifts" /id="U1604" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=821 /SigmaFactorBS="ttcgccgtgaaaacacctgtagcggcatgtgccCACATAAaa agtgccagagcGGAAACAATAGAtgctgtgataaaccaaggaatgccttttggccctt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1961743..1961749) /Source="Nicolas_upshift_promotors" /id="U1604" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=821 /SigmaFactorBS="ttcgccgtgaaaacacctgtagcggcatgtgccCACATAAaa agtgccagagcGGAAACAATAGAtgctgtgataaaccaaggaatgccttttggccctt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1962461 /Source="Nicolas_upshifts" /id="D1078" /incds=0 /nref=128 /ntot=189 /MaxReadThrough="1.75716" /MaxDrop="6.37839" /score="42.3111155" /energy="-14.6" /TU="NA" /idTUdmin="U1603" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" CDS complement(1962508..1963908) /gene="ctpA" /locus_tag="BSU_19590" /old_locus_tag="BSU19590" /EC_number="3.4.21.102" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8996100, 10974125, 14526016, 17114254, 19889088; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="carboxy-terminal processing protease (Prc homolog, tail specific protease)" /protein_id="NP_389840.1" /db_xref="EnsemblGenomes-Gn:BSU19590" /db_xref="EnsemblGenomes-Tr:CAB13850" /db_xref="GOA:O34666" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR002477" /db_xref="InterPro:IPR004447" /db_xref="InterPro:IPR005151" /db_xref="InterPro:IPR029045" /db_xref="InterPro:IPR036034" /db_xref="InterPro:IPR036365" /db_xref="InterPro:IPR036366" /db_xref="SubtiList:BG11794" /db_xref="UniProtKB/Swiss-Prot:O34666" /translation="MKRQLKLFFIVLITAVVASALTLFITGNSSILGQKSASTGDSKF DKLNKAYEQIKSDYYQKTDDDKLVDGAIKGMIQSLDDPYSTYMDQEQAKSFDETISAS FEGIGAQVEEKDGEILIVSPIKGSPAEKAGIKPRDQIIKVNGKSVKGMNVNEAVALIR GKKGTKVKLELNRAGVGNIDLSIKRDTIPVETVYSEMKDNNIGEIQITSFSETTAKEL TDAIDSLEKKGAKGYILDLRGNPGGLMEQAITMSNLFIDKGKNIMQVEYKNGSKEVMK AEKERKVTKPTVVLVNDGTASAAEIMAAALHESSNVPLIGETTFGKGTVQTAKEYDDG STVKLTVAKWLTADGEWIHKKGIKPQVKAELPDYAKLPYLDADKTYKSGDTGTNVKVA QKMLKALGYKVKVNSMYDQDFVSVVKQFQKKEKLNETGILTGDTTTKLMIELQKKLSD NDTQMEKAIETLKKEM*" /label="ctpA CDS" gene complement(1962508..1963908) /gene="ctpA" /locus_tag="BSU_19590" /old_locus_tag="BSU19590" /label="ctpA gene" downshifts complement(1962532) /Source="Nicolas_upshifts" /id="D1079" /incds=0 /nref=188 /ntot=292 /MaxReadThrough="0.590400000000001" /MaxDrop="7.62713" /score="34.5981085" /energy="-14.6" /TU="NA" /idTUdmin="U1606" /TUdmin="-18" /isTUend="TRUE" /label="downshifts" promotor_-35 1963679..1963688 /Source="Nicolas_upshift_promotors" /id="U1605" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=383 /SigmaFactorBS="tgtagaatacggatcatccagtgatTGAATCATTCctttaat tgctCCGTCTACTAATTTGTcatcatctgttttttggtaataatcacttttgatttgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1963700..1963715 /Source="Nicolas_upshift_promotors" /id="U1605" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=383 /SigmaFactorBS="tgtagaatacggatcatccagtgatTGAATCATTCctttaat tgctCCGTCTACTAATTTGTcatcatctgttttttggtaataatcacttttgatttgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1963714 /Source="Nicolas_upshifts" /id="U1605" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=383 /SigmaFactorBS="tgtagaatacggatcatccagtgatTGAATCATTCctttaat tgctCCGTCTACTAATTTGTcatcatctgttttttggtaataatcacttttgatttgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1963928..1963947) /Source="Nicolas_upshift_promotors" /id="U1606" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.878121878121878" /psig=1 /xcortree=3142 /SigmaFactorBS="gaaaagcaaaagaagggcgtttctctttcatttctgctccGA GTTGACgaataagaattcgTCCATGATAATAATGTAAGAagaaaaaggtggtgtttaa t" /listShort="ctpA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1963948) /Source="Nicolas_upshifts" /id="U1606" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.878121878121878" /psig=1 /xcortree=3142 /SigmaFactorBS="gaaaagcaaaagaagggcgtttctctttcatttctgctccGA GTTGACgaataagaattcgTCCATGATAATAATGTAAGAagaaaaaggtggtgtttaa t" /listShort="ctpA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1963961..1963968) /Source="Nicolas_upshift_promotors" /id="U1606" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.878121878121878" /psig=1 /xcortree=3142 /SigmaFactorBS="gaaaagcaaaagaagggcgtttctctttcatttctgctccGA GTTGACgaataagaattcgTCCATGATAATAATGTAAGAagaaaaaggtggtgtttaa t" /listShort="ctpA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1964007..1964016 /Source="Nicolas_upshift_promotors" /id="U1607" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1327 /SigmaFactorBS="tcaactcggagcagaaatgaaagagaaacgcccttcttttgc tttTCATAAACCTatgtctttatacGACATATGATAAGGAAAAAGgaggattcgatat t" /listShort="yodH, yodI" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 1964022 /Source="Nicolas_upshifts" /id="U1607" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1327 /SigmaFactorBS="tcaactcggagcagaaatgaaagagaaacgcccttcttttgc tttTCATAAACCTatgtctttatacGACATATGATAAGGAAAAAGgaggattcgatat t" /listShort="yodH, yodI" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1964029..1964048 /Source="Nicolas_upshift_promotors" /id="U1607" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1327 /SigmaFactorBS="tcaactcggagcagaaatgaaagagaaacgcccttcttttgc tttTCATAAACCTatgtctttatacGACATATGATAAGGAAAAAGgaggattcgatat t" /listShort="yodH, yodI" /GFF_Attribute="listLong" /label="promotor_-10" CDS 1964061..1964762 /gene="yodH" /locus_tag="BSU_19600" /old_locus_tag="BSU19600" /EC_number="2.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 19703276; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative S-adenosylmethionine-dependent methyltransferase" /protein_id="NP_389841.1" /db_xref="EnsemblGenomes-Gn:BSU19600" /db_xref="EnsemblGenomes-Tr:CAB13851" /db_xref="GOA:O34954" /db_xref="InterPro:IPR013216" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG13536" /db_xref="UniProtKB/Swiss-Prot:O34954" /translation="MSRYLEMLSLFGVAGAHPGGLAFSKAVLQKAAPSPDQPILDAGC GTGQTAAYLGHLLYPVTVVDKDPIMLEKAKKRFANEGLAIPAYQAELEHLPFSSESFS CVLSESVLSFSRLTSSLQEISRVLKPSGMLIGIEAALKKPMPPAEKKQMMDFYGFTCL HEESEWHKLLRSYGFQKTEAMSLLPEDMEFEPTTEMDLSQTIDPIYYDTLQTHYQLMQ LYSEYMGHCIFIAYK*" /label="yodH CDS" gene 1964061..1964762 /gene="yodH" /locus_tag="BSU_19600" /old_locus_tag="BSU19600" /label="yodH gene" promotor_-35 1964787..1964795 /Source="Nicolas_upshift_promotors" /id="U1608" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1407 /SigmaFactorBS="tacaagtaaaacggcgtatcgccccctgttttcGTCCAACCT ttttttcctatctATCATATGCTGATAGAAAGTcaggataggaggggaacaatattgg a" /listShort="yodI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1964809..1964828 /Source="Nicolas_upshift_promotors" /id="U1608" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1407 /SigmaFactorBS="tacaagtaaaacggcgtatcgccccctgttttcGTCCAACCT ttttttcctatctATCATATGCTGATAGAAAGTcaggataggaggggaacaatattgg a" /listShort="yodI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1964814 /Source="Nicolas_upshifts" /id="U1608" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1407 /SigmaFactorBS="tacaagtaaaacggcgtatcgccccctgttttcGTCCAACCT ttttttcctatctATCATATGCTGATAGAAAGTcaggataggaggggaacaatattgg a" /listShort="yodI" /GFF_Attribute="listLong" /label="upshifts" CDS 1964850..1965101 /gene="yodI" /locus_tag="BSU_19610" /old_locus_tag="BSU19610" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12562816, 22882546, 23155385; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="NP_389842.1" /db_xref="EnsemblGenomes-Gn:BSU19610" /db_xref="EnsemblGenomes-Tr:CAB13852" /db_xref="GOA:O34654" /db_xref="SubtiList:BG13537" /db_xref="UniProtKB/Swiss-Prot:O34654" /translation="MERYYHLCKNHQGKVVRITERGGRVHVGRITRVTRDRVFIAPVG GGPRGFGYGYWGGYWGYGAAYGISLGLIAGVALAGLFFW*" /label="yodI CDS" gene 1964850..1965101 /gene="yodI" /locus_tag="BSU_19610" /old_locus_tag="BSU19610" /label="yodI gene" downshifts 1965122 /Source="Nicolas_upshifts" /id="D1080" /incds=0 /nref=49 /ntot=83 /MaxReadThrough="0.88268" /MaxDrop="7.18785" /score="13.9812819" /energy="-15.5" /TU="NA" /idTUdmin="U1607" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1965172..1965993) /gene="ldcB" /locus_tag="BSU_19620" /old_locus_tag="BSU19620" /EC_number="3.4.16.4" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:8631706, 15187182, 24909784" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8631706, 15187182, 24909784; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-alanyl-D-alanine carboxypeptidase lipoprotein (D-ala releasing from tetrapeptide hydrolysis)" /protein_id="NP_389843.1" /db_xref="EnsemblGenomes-Gn:BSU19620" /db_xref="EnsemblGenomes-Tr:CAB13853" /db_xref="GOA:O34866" /db_xref="InterPro:IPR003709" /db_xref="InterPro:IPR009045" /db_xref="PDB:4OX3" /db_xref="SubtiList:BG13538" /db_xref="UniProtKB/Swiss-Prot:O34866" /translation="MKKSGKWFSLAAALSVTAIVGAGCSMSNGDAQKDTKTTAETKQT EQKTADSKKSNTQNSEFSLESQYFNDIKKVDGLETIQNPENILALVNKQYALPGNYEP SDLVIPDVEFSFEEKIQKRYIRKEAADALKTMFDAAKKEGYELAAVSGYRSYDRQKVI FDNEVSLKGERKAKEAVAYPGESEHQTGLAMDISSRSNGFELNEAFGSTADGKWVQDN AYKYGFIIRYPKNKEDITKYEYEPWHLRYVGKKAAKVIQDNDLTLEEYFEKVKKI*" /label="ldcB CDS" gene complement(1965172..1965993) /gene="ldcB" /locus_tag="BSU_19620" /old_locus_tag="BSU19620" /label="ldcB gene" downshifts complement(1965198) /Source="Nicolas_upshifts" /id="D1081" /incds=0 /nref=180 /ntot=242 /MaxReadThrough="0.784690000000001" /MaxDrop="5.88637" /score="-9.13236272" /energy="-6.1" /TU="NA" /idTUdmin="U1609" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(1965994..1966075) /Source="Nicolas_S_feature" /locus_tag="new_2135388_2135469_c" /HighExp="dia15, LBGexp, G180, LBGtran, dia0, H2O2, Oxctl, Lbexp, Paraq, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S755" CDS complement(1966076..1966777) /gene="deoD" /locus_tag="BSU_19630" /old_locus_tag="BSU19630" /EC_number="2.4.2.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12571059, 16511068, 21279421, 21424839" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12571059, 16511068, 21279421, 21424839; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="purine nucleoside phosphorylase" /protein_id="NP_389844.1" /db_xref="EnsemblGenomes-Gn:BSU19630" /db_xref="EnsemblGenomes-Tr:CAB13854" /db_xref="GOA:O34925" /db_xref="InterPro:IPR000845" /db_xref="InterPro:IPR004402" /db_xref="InterPro:IPR018016" /db_xref="InterPro:IPR035994" /db_xref="PDB:4D8V" /db_xref="PDB:4D8X" /db_xref="PDB:4D8Y" /db_xref="PDB:4D98" /db_xref="PDB:4D9H" /db_xref="PDB:4DA0" /db_xref="PDB:4DA6" /db_xref="PDB:4DA7" /db_xref="PDB:4DA8" /db_xref="PDB:4DAB" /db_xref="PDB:4DAE" /db_xref="PDB:4DAN" /db_xref="PDB:4DAO" /db_xref="PDB:4DAR" /db_xref="SubtiList:BG12581" /db_xref="UniProtKB/Swiss-Prot:O34925" /translation="MSVHIGAEKGQIADTVLLPGDPLRAKFIAETYLENVECYNEVRG MYGFTGTYKGKKISVQGTGMGVPSISIYVNELIQSYDVQNLIRVGSCGAIRKDVKVRD VILAMTSSTDSQMNRVAFGSVDFAPCADFELLKNAYDAAKDKGVPVTVGSVFTADQFY NDDSQIEKLAKYGVLGVEMETTALYTLAAKHGRKALSILTVSDHVLTGEETTAEERQT TFHDMIEVALHSVSQ*" /label="deoD CDS" gene complement(1966076..1966777) /gene="deoD" /locus_tag="BSU_19630" /old_locus_tag="BSU19630" /label="deoD gene" S_feature complement(1966778..1966867) /Source="Nicolas_S_feature" /locus_tag="new_2136172_2136261_c" /HighExp="dia15, G180, dia5, LBGtran, dia0, LBGexp, Lbexp, G150, Oxctl, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S756" promotor_-10 complement(1966852..1966871) /Source="Nicolas_upshift_promotors" /id="U1609" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.65034965034965" /psig="0.999000999001" /xcortree=2571 /SigmaFactorBS="ccgtttttctgaggaagtgcctaacagatcctcgaaCATTTc ttttttcgatatatTCCTTTATAATCAATGCTGAagtttgtttcatcatgacattcgt t" /listShort="S756, deoD, S755, yodJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1966867) /Source="Nicolas_upshifts" /id="U1609" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.65034965034965" /psig="0.999000999001" /xcortree=2571 /SigmaFactorBS="ccgtttttctgaggaagtgcctaacagatcctcgaaCATTTc ttttttcgatatatTCCTTTATAATCAATGCTGAagtttgtttcatcatgacattcgt t" /listShort="S756, deoD, S755, yodJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1966887..1966891) /Source="Nicolas_upshift_promotors" /id="U1609" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.65034965034965" /psig="0.999000999001" /xcortree=2571 /SigmaFactorBS="ccgtttttctgaggaagtgcctaacagatcctcgaaCATTTc ttttttcgatatatTCCTTTATAATCAATGCTGAagtttgtttcatcatgacattcgt t" /listShort="S756, deoD, S755, yodJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 1966925..1966931 /Source="Nicolas_upshift_promotors" /id="U1610" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=862 /SigmaFactorBS="gttaggcacttcctcagaaaaaCGGATAAtcggggtgttaat tTGAAAACCTAACcgcaggaaggaggggtgggacatgggtaaaaaacatcgtaaccgg a" /listShort="yoyE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1966946..1966957 /Source="Nicolas_upshift_promotors" /id="U1610" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=862 /SigmaFactorBS="gttaggcacttcctcagaaaaaCGGATAAtcggggtgttaat tTGAAAACCTAACcgcaggaaggaggggtgggacatgggtaaaaaacatcgtaaccgg a" /listShort="yoyE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1966963 /Source="Nicolas_upshifts" /id="U1610" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=862 /SigmaFactorBS="gttaggcacttcctcagaaaaaCGGATAAtcggggtgttaat tTGAAAACCTAACcgcaggaaggaggggtgggacatgggtaaaaaacatcgtaaccgg a" /listShort="yoyE" /GFF_Attribute="listLong" /label="upshifts" CDS 1966979..1967104 /gene="yoyE" /locus_tag="BSU_19639" /old_locus_tag="BSU19639" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 24079885" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097743.1" /db_xref="EnsemblGenomes-Gn:BSU19639" /db_xref="EnsemblGenomes-Tr:CAX52640" /db_xref="UniProtKB/Swiss-Prot:C0H432" /translation="MGKKHRNRITGQKKNNHIPEKDIIAAEEAHGKEYSAAKRKP*" /label="yoyE CDS" gene 1966979..1967104 /gene="yoyE" /locus_tag="BSU_19639" /old_locus_tag="BSU19639" /label="yoyE gene" downshifts 1967102 /Source="Nicolas_upshifts" /id="D1082" /incds=0 /nref=9 /ntot=26 /MaxReadThrough="0.67198" /MaxDrop="4.89617" /score="16.4028635" /energy="-8.5" /TU="NA" /idTUdmin="U1610" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1967144..1967458) /gene="yodL" /locus_tag="BSU_19640" /old_locus_tag="BSU19640" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:24079885, 27215790" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 24079885, 27215790; Product type f: factor" /codon_start=1 /transl_table=11 /product="shape determination factor" /protein_id="NP_389845.2" /db_xref="EnsemblGenomes-Gn:BSU19640" /db_xref="EnsemblGenomes-Tr:CAB13855" /db_xref="InterPro:IPR025923" /db_xref="SubtiList:BG13539" /db_xref="UniProtKB/Swiss-Prot:O30472" /translation="MMLSVFKKKSCSYDVTIFQTPRFGEKKGYRAVYRTELNGSDHQD VLKRAFSLFNVFDTVPSDYDARFMATGDVILIDEGRKGKTYYQLLPAGWRKINRLIVQ TT*" /label="yodL CDS" gene complement(1967144..1967458) /gene="yodL" /locus_tag="BSU_19640" /old_locus_tag="BSU19640" /label="yodL gene" downshifts complement(1967156) /Source="Nicolas_upshifts" /id="D1083" /incds=0 /nref=96 /ntot=232 /MaxReadThrough="1.74792" /MaxDrop="5.79235" /score="-0.334745097" /energy="-8.5" /TU="NA" /idTUdmin="U1611" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(1967479..1967497) /Source="Nicolas_upshift_promotors" /id="U1611" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=447 /SigmaFactorBS="aaagattaagcggtttcgacaaaaatagagAGAGGAAAAcac agcaaaaACGCCAATATGTTAAAGAAataaaagggaggggatcttgatgatgttatcc g" /listShort="yodL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1967486) /Source="Nicolas_upshifts" /id="U1611" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=447 /SigmaFactorBS="aaagattaagcggtttcgacaaaaatagagAGAGGAAAAcac agcaaaaACGCCAATATGTTAAAGAAataaaagggaggggatcttgatgatgttatcc g" /listShort="yodL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1967508..1967516) /Source="Nicolas_upshift_promotors" /id="U1611" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=447 /SigmaFactorBS="aaagattaagcggtttcgacaaaaatagagAGAGGAAAAcac agcaaaaACGCCAATATGTTAAAGAAataaaagggaggggatcttgatgatgttatcc g" /listShort="yodL" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1967519..1968130) /gene="pgpB" /locus_tag="BSU_19650" /old_locus_tag="BSU19650" /EC_number="3.1.3.27" /EC_number="3.1.3.-" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 27528508, 28168443" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 27528508, 28168443; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphatidylglycerol phosphate (PGP) phosphatase; undecaprenyl-pyrophosphate phosphatase (promiscuous activity)" /protein_id="NP_389846.1" /db_xref="EnsemblGenomes-Gn:BSU19650" /db_xref="EnsemblGenomes-Tr:CAB13856" /db_xref="GOA:O34349" /db_xref="InterPro:IPR000326" /db_xref="InterPro:IPR036938" /db_xref="PDB:5JKI" /db_xref="SubtiList:BG13540" /db_xref="UniProtKB/Swiss-Prot:O34349" /translation="MYKPVSLFLFFLILAAAIHTNAVQSADEAISKAAVLIRQPWLNE VMTGITHLGASSFLLPLIVIIGAGMFFYRKTWDGLLMLLVFGTDRLLNKVLKEWIERV RPDFAPLVHESSFSFPSGHSMNAACVYPVIAYFLVKHLPFLSKHKKMVYIIAGVIAVL VGISRVYLGVHFVTDVLGGFSLGLLLFFLVKGFDEKIKRFRQK*" /label="pgpB CDS" gene complement(1967519..1968130) /gene="pgpB" /locus_tag="BSU_19650" /old_locus_tag="BSU19650" /label="pgpB gene" CDS complement(1968208..1968384) /gene="yozD" /locus_tag="BSU_19660" /old_locus_tag="BSU19660" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389847.1" /db_xref="EnsemblGenomes-Gn:BSU19660" /db_xref="EnsemblGenomes-Tr:CAB13857" /db_xref="InterPro:IPR025545" /db_xref="SubtiList:BG13751" /db_xref="UniProtKB/Swiss-Prot:O31863" /translation="MKEIDLVIDTEEIAEFFYRELARRGYIPSEDELFEIADITFDYL IEKCMIDEELDEDE*" /label="yozD CDS" gene complement(1968208..1968384) /gene="yozD" /locus_tag="BSU_19660" /old_locus_tag="BSU19660" /label="yozD gene" downshifts complement(1968212) /Source="Nicolas_upshifts" /id="D1084" /incds=0 /nref=35 /ntot=48 /MaxReadThrough="3.33111" /MaxDrop="5.99901" /score="19.8458751" /energy="-11.9" /TU="U1612,U1613" /idTUdmin="U1615" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts complement(1968223) /Source="Nicolas_upshifts" /id="U1612" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.51048951048951" /psig="0.934065934065934" /xcortree=2494 /SigmaFactorBS="tgaaatcgctgatattacCTTTgattatttgatagaaAAATG TATGATAGATGAAGAgctggatgaagatgagtgaggcttaaaaccggagcggtcagct c" /listShort="yodM, yodL" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1968227..1968246) /Source="Nicolas_upshift_promotors" /id="U1612" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.51048951048951" /psig="0.934065934065934" /xcortree=2494 /SigmaFactorBS="tgaaatcgctgatattacCTTTgattatttgatagaaAAATG TATGATAGATGAAGAgctggatgaagatgagtgaggcttaaaaccggagcggtcagct c" /listShort="yodM, yodL" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1968262..1968265) /Source="Nicolas_upshift_promotors" /id="U1612" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.51048951048951" /psig="0.934065934065934" /xcortree=2494 /SigmaFactorBS="tgaaatcgctgatattacCTTTgattatttgatagaaAAATG TATGATAGATGAAGAgctggatgaagatgagtgaggcttaaaaccggagcggtcagct c" /listShort="yodM, yodL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1968398..1968416) /Source="Nicolas_upshift_promotors" /id="U1613" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1118 /SigmaFactorBS="tttttattcaatatatgactgaaagaattgtttagaacaccg GGTATAattcagcctgtttttTCATAAAACATAAAAAAGGaggcggtacggagatgaa a" /listShort="yozD, yodM" /listLong="yodL" /label="promotor_-10" upshifts complement(1968419) /Source="Nicolas_upshifts" /id="U1613" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1118 /SigmaFactorBS="tttttattcaatatatgactgaaagaattgtttagaacaccg GGTATAattcagcctgtttttTCATAAAACATAAAAAAGGaggcggtacggagatgaa a" /listShort="yozD, yodM" /listLong="yodL" /label="upshifts" S_feature complement(1968421..1968642) /Source="Nicolas_S_feature" /locus_tag="new_2137815_2138036_c" /HighExp="S8, S7, S6, BT, B36, Pyr, G/S, H2O2, S5, G135" /AntisenseName="yoyF" /AntisenseCor="0.43167183745996701" /AntisenseRegPval="-12.9" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S757" promotor_-35 complement(1968432..1968437) /Source="Nicolas_upshift_promotors" /id="U1613" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1118 /SigmaFactorBS="tttttattcaatatatgactgaaagaattgtttagaacaccg GGTATAattcagcctgtttttTCATAAAACATAAAAAAGGaggcggtacggagatgaa a" /listShort="yozD, yodM" /listLong="yodL" /label="promotor_-35" promotor_-35 1968442..1968447 /Source="Nicolas_upshift_promotors" /id="U1614" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=997 /SigmaFactorBS="ttatgttttatgaaaaaacaggctgaattatacccggtGTTC TAaacaattctttcagTCATATATTGAATAAAAAAcgagccatgggaggctgacgcta t" /listShort="yoyF, S758" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1968462..1968480 /Source="Nicolas_upshift_promotors" /id="U1614" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=997 /SigmaFactorBS="ttatgttttatgaaaaaacaggctgaattatacccggtGTTC TAaacaattctttcagTCATATATTGAATAAAAAAcgagccatgggaggctgacgcta t" /listShort="yoyF, S758" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1968464 /Source="Nicolas_upshifts" /id="U1614" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=997 /SigmaFactorBS="ttatgttttatgaaaaaacaggctgaattatacccggtGTTC TAaacaattctttcagTCATATATTGAATAAAAAAcgagccatgggaggctgacgcta t" /listShort="yoyF, S758" /GFF_Attribute="listLong" /label="upshifts" CDS 1968503..1968646 /gene="yoyF" /locus_tag="BSU_19669" /old_locus_tag="BSU19669" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097744.1" /db_xref="EnsemblGenomes-Gn:BSU19669" /db_xref="EnsemblGenomes-Tr:CAX52641" /db_xref="GOA:C0H433" /db_xref="UniProtKB/Swiss-Prot:C0H433" /translation="MIAKMMEALDGERFDIIMEKTLKGMTRVMIWGCLPYFLYVLIRM FTN*" /label="yoyF CDS" gene 1968503..1968646 /gene="yoyF" /locus_tag="BSU_19669" /old_locus_tag="BSU19669" /label="yoyF gene" CDS complement(1968643..1969323) /gene="yodN" /locus_tag="BSU_19670" /old_locus_tag="BSU19670" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_389848.1" /db_xref="EnsemblGenomes-Gn:BSU19670" /db_xref="EnsemblGenomes-Tr:CAB13858" /db_xref="SubtiList:BG13541" /db_xref="UniProtKB/Swiss-Prot:O34414" /translation="MKQNKPKFQVGDIVVVIMYGTVGTITKVHQIDKHYLYEVNHNEV LYFESSIQLYKDYEGVIVDMEKLDIEYEFLIGDVVYVKDYGKELFRIIGHRTEIWRYL EDGWEDIIYELTRLKDGEWLETEEEDLTLVLRKYEMDQFVHQLLFVHYVGETGHEIGE DIASSALLQFEGGDEDQDTLHILAVSIVDELLDIYNDYKILYEMFQDEEYKDMMMFVL ESLKEHFS*" /label="yodN CDS" gene complement(1968643..1969323) /gene="yodN" /locus_tag="BSU_19670" /old_locus_tag="BSU19670" /label="yodN gene" S_feature 1968647..1969658 /Source="Nicolas_S_feature" /locus_tag="new_2138041_2139052" /HighExp="LoTm, S3, S8, S7, S4, T5.0H, BT, T4.0H, Pyr, S6" /AntisenseName="yodN" /AntisenseCor="0.52628108909126403" /AntisenseRegPval="-19.8" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S758" promotor_-10 complement(1969350..1969369) /Source="Nicolas_upshift_promotors" /id="U1615" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1356 /SigmaFactorBS="ttggatatttcctttggttttcatGCCCATGCGAattggctt cacccGGCATACGATAGCGTATGAGaaatgttgcggcgagggggagacaccatgaagc a" /listShort="yodN, S757, yozD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1969356) /Source="Nicolas_upshifts" /id="U1615" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1356 /SigmaFactorBS="ttggatatttcctttggttttcatGCCCATGCGAattggctt cacccGGCATACGATAGCGTATGAGaaatgttgcggcgagggggagacaccatgaagc a" /listShort="yodN, S757, yozD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1969383..1969392) /Source="Nicolas_upshift_promotors" /id="U1615" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1356 /SigmaFactorBS="ttggatatttcctttggttttcatGCCCATGCGAattggctt cacccGGCATACGATAGCGTATGAGaaatgttgcggcgagggggagacaccatgaagc a" /listShort="yodN, S757, yozD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1969474..1969698) /gene="yozE" /locus_tag="BSU_19680" /old_locus_tag="BSU19680" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22843344" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_389849.1" /db_xref="EnsemblGenomes-Gn:BSU19680" /db_xref="EnsemblGenomes-Tr:CAB13859" /db_xref="InterPro:IPR010673" /db_xref="InterPro:IPR023089" /db_xref="InterPro:IPR036806" /db_xref="PDB:2FJ6" /db_xref="SubtiList:BG13752" /db_xref="UniProtKB/Swiss-Prot:O31864" /translation="MKSFYHYLLKYRHPKPKDSISEFANQAYEDHSFPKTSTDYHEIS SYLELNADYLHTMATFDEAWDQYESEVHGR*" /label="yozE CDS" gene complement(1969474..1969698) /gene="yozE" /locus_tag="BSU_19680" /old_locus_tag="BSU19680" /label="yozE gene" downshifts complement(1969488) /Source="Nicolas_upshifts" /id="D1085" /incds=0 /nref=115 /ntot=243 /MaxReadThrough="1.81033" /MaxDrop="7.07662" /score="34.0666929" /energy="-10.8" /TU="NA" /idTUdmin="U1616" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(1969739..1969758) /Source="Nicolas_upshift_promotors" /id="U1616" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.619380619380619" /psig="0.983016983016983" /xcortree=637 /SigmaFactorBS="aaacgcaactattttgacttctcctgagtcatgtttcagtat tcttttgttgtAATTTTACACTTGAACTGTAtaatagaacaacaaaagacagacatca g" /listShort="yozE" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1969751) /Source="Nicolas_upshifts" /id="U1616" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.619380619380619" /psig="0.983016983016983" /xcortree=637 /SigmaFactorBS="aaacgcaactattttgacttctcctgagtcatgtttcagtat tcttttgttgtAATTTTACACTTGAACTGTAtaatagaacaacaaaagacagacatca g" /listShort="yozE" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1969785..1970063) /gene="yokU" /locus_tag="BSU_19689" /old_locus_tag="BSU19689" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22843344, 24914178" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097745.1" /db_xref="EnsemblGenomes-Gn:BSU19689" /db_xref="EnsemblGenomes-Tr:CAX52642" /db_xref="InterPro:IPR022451" /db_xref="InterPro:IPR022453" /db_xref="UniProtKB/Swiss-Prot:C0H434" /translation="MKTCEWCGELEAVPGRNTVYWELPDGTRAIELTDTPAMVCSSCG MTYQEENTVKEIEDQLLLIQTKKLPESLTYQQLMETERILKRNYFDFS*" /label="yokU CDS" gene complement(1969785..1970063) /gene="yokU" /locus_tag="BSU_19689" /old_locus_tag="BSU19689" /label="yokU gene" CDS complement(1970060..1971475) /gene="kamA" /locus_tag="BSU_19690" /old_locus_tag="BSU19690" /EC_number="5.4.3.2" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10629195, 10839984, 11148055, 17254853, 18307109, 21538109" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10629195, 10839984, 11148055, 17254853, 18307109, 21538109; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="lysine 2,3-aminomutase" /protein_id="NP_389850.1" /db_xref="EnsemblGenomes-Gn:BSU19690" /db_xref="EnsemblGenomes-Tr:CAB13860" /db_xref="GOA:O34676" /db_xref="InterPro:IPR003739" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR022459" /db_xref="InterPro:IPR025895" /db_xref="SubtiList:BG13542" /db_xref="UniProtKB/Swiss-Prot:O34676" /translation="MKNKWYKPKRHWKEIELWKDVPEEKWNDWLWQLTHTVRTLDDLK KVINLTEDEEEGVRISTKTIPLNITPYYASLMDPDNPRCPVRMQSVPLSEEMHKTKYD LEDPLHEDEDSPVPGLTHRYPDRVLFLVTNQCSMYCRYCTRRRFSGQIGMGVPKKQLD AAIAYIRETPEIRDCLISGGDGLLINDQILEYILKELRSIPHLEVIRIGTRAPVVFPQ RITDHLCEILKKYHPVWLNTHFNTSIEMTEESVEACEKLVNAGVPVGNQAVVLAGIND SVPIMKKLMHDLVKIRVRPYYIYQCDLSEGIGHFRAPVSKGLEIIEGLRGHTSGYAVP TFVVDAPGGGGKIALQPNYVLSQSPDKVILRNFEGVITSYPEPENYIPNQADAYFESV FPETADKKEPIGLSAIFADKEVSFTPENVDRIKRREAYIANPEHETLKDRREKRDQLK EKKFLAQQKKQKETECGGDSS*" /label="kamA CDS" gene complement(1970060..1971475) /gene="kamA" /locus_tag="BSU_19690" /old_locus_tag="BSU19690" /label="kamA gene" promotor_-35 1970731..1970734 /Source="Nicolas_upshift_promotors" /id="U1617" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.68031968031968" /psig="0.995004995004995" /xcortree=2431 /SigmaFactorBS="ccgcgttcaccagcttttcacatgcctcaacggattCTTCtg tcatttcgatgctTGTGTTAAAATGGGTGTTCAgccagaccggatgatattttttcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1970750..1970769 /Source="Nicolas_upshift_promotors" /id="U1617" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.68031968031968" /psig="0.995004995004995" /xcortree=2431 /SigmaFactorBS="ccgcgttcaccagcttttcacatgcctcaacggattCTTCtg tcatttcgatgctTGTGTTAAAATGGGTGTTCAgccagaccggatgatattttttcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1970755 /Source="Nicolas_upshifts" /id="U1617" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.68031968031968" /psig="0.995004995004995" /xcortree=2431 /SigmaFactorBS="ccgcgttcaccagcttttcacatgcctcaacggattCTTCtg tcatttcgatgctTGTGTTAAAATGGGTGTTCAgccagaccggatgatattttttcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1971504..1972331) /gene="kamB" /locus_tag="BSU_19700" /old_locus_tag="BSU19700" /EC_number="2.3.1.-" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:21538109, 24914178" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21538109, 24914178; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="epsilon-amino-beta-lysine acetyl transferase" /protein_id="NP_389851.1" /db_xref="EnsemblGenomes-Gn:BSU19700" /db_xref="EnsemblGenomes-Tr:CAB13861" /db_xref="GOA:O34895" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR022525" /db_xref="InterPro:IPR029025" /db_xref="SubtiList:BG13543" /db_xref="UniProtKB/Swiss-Prot:O34895" /translation="MLKSIKSSGVTAVLDHDGFNKRIRVVRYDGAIEKALPDIVAAAK EENAEKIIVYAKQHDEPILAKQLFAPEGYLKGYYLGHSACVMVRYLSESRRQTDSYTE EQEIIEAIYRTAPRLRNDSTPVFTMRKAETNDMYQLSMLYKKVFRTYPTPVFDPAYIE KTMNANTVYYIMLDHDRLISAASAEINPELGHAEITDCAVLPEYRGHSLTSFLIEALE KEMAGEDIVHVFSLARASSFGMNAVLYHSGYQYGGRLINNCFIAEGLENMNIWCKQL* " /label="kamB CDS" gene complement(1971504..1972331) /gene="kamB" /locus_tag="BSU_19700" /old_locus_tag="BSU19700" /label="kamB gene" CDS complement(1972309..1973619) /gene="yodQ" /locus_tag="BSU_19710" /old_locus_tag="BSU19710" /EC_number="3.5.1.-" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23944997, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative deacetylase" /protein_id="NP_389852.1" /db_xref="EnsemblGenomes-Gn:BSU19710" /db_xref="EnsemblGenomes-Tr:CAB13862" /db_xref="GOA:O34984" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR010182" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR033687" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG12569" /db_xref="UniProtKB/Swiss-Prot:O34984" /translation="MRMQDIERKVIEWLDQHSAKAIRLLKRLIGEKSTLGSEFNAQAV VLEKLRQFHMDIDVWEPSIKQLKQHPYFKSNRSDFHESPNIVAKKTGAGGGRSLILNG HIDVVPEGSVKDWKYEPYQAVEENGKIYGRGSTDMKGGNTALLFALEALHACDVKLKG DVLFQSVVDEECGGAGTLSAIMRGYRADGALIPEPTNMKLFIKQQGSMWFRITVKGLS AHGGTRYEGVSAIEKSMHVITAIQELEKVRNARISDPLYDNIPIPVPVNIGTISGGAW PSSVADRVVIEGRCGIAPHEKPEAVKLELENWLKDLEYHDEWFKRHPVQVEWFGAQWL PNDLPDDHPLISVLQSAYQKMKQTEPIIEASPWGTDGGLLYHAGDTPVIVFGPGETKT AHQANEYIEVEAMIESAKIIALFVMDWCGLHTDGEDADAQVNKE*" /label="yodQ CDS" gene complement(1972309..1973619) /gene="yodQ" /locus_tag="BSU_19710" /old_locus_tag="BSU19710" /label="yodQ gene" CDS complement(1973628..1974281) /gene="yodR" /locus_tag="BSU_19720" /old_locus_tag="BSU19720" /EC_number="2.8.3.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15150230, 21538109, 24914178; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyloate-acetoacetate CoA-transferase" /protein_id="NP_389853.1" /db_xref="EnsemblGenomes-Gn:BSU19720" /db_xref="EnsemblGenomes-Tr:CAB13863" /db_xref="GOA:O34466" /db_xref="InterPro:IPR004165" /db_xref="InterPro:IPR012791" /db_xref="SubtiList:BG13544" /db_xref="UniProtKB/Swiss-Prot:O34466" /translation="MGLGVAEREQIAKRAATEIKQGMIVNLGIGIPSLVPNFLKPDMQ VMFQAENGVLGIGESPEKGEEDAHLCNAAGYPVRAVKGASYFDTTMSFAMIRKGKIDI TILGALQVSQSGDLANWLVPGKKVPGMGGAMELAQKAKKVVVVMSHTDQKGRPKLTER CTLPLTAAGCVDLIITEKAVLEVDSHHFILKELMNGSTIDEVTRLTEAEIKIDMPFS* " /label="yodR CDS" gene complement(1973628..1974281) /gene="yodR" /locus_tag="BSU_19720" /old_locus_tag="BSU19720" /label="yodR gene" CDS complement(1974266..1974955) /gene="yodS" /locus_tag="BSU_19730" /old_locus_tag="BSU19730" /EC_number="2.8.3.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15150230, 21538109, 24914178; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxoacid CoA-transferase" /protein_id="NP_389854.1" /db_xref="EnsemblGenomes-Gn:BSU19730" /db_xref="EnsemblGenomes-Tr:CAB13864" /db_xref="GOA:O34317" /db_xref="InterPro:IPR004163" /db_xref="InterPro:IPR004165" /db_xref="InterPro:IPR012792" /db_xref="SubtiList:BG13545" /db_xref="UniProtKB/Swiss-Prot:O34317" /translation="MAPFQKAISIDTAIADVRDGSVLMFGGFGGVGSPPSLIEAILDS GVTDLTVICNDAGFPDIGIGPLIVNQRVKTLIASHIGSNPVAGKQMTEGTLEVQFSPQ GTLAERIRAGGAGLGGILTDVGIDNQMVCEKKDIVTVAGKRYLIEEALTADFAFINAY IADEFGNLTYDKTARNMNPLMAMAARRTFAEAERIVPMGEISEEMIVTPGVFVEGVVR SEGVKWKWAWE*" /label="yodS CDS" gene complement(1974266..1974955) /gene="yodS" /locus_tag="BSU_19730" /old_locus_tag="BSU19730" /label="yodS gene" CDS complement(1974962..1976296) /gene="yodT" /locus_tag="BSU_19740" /old_locus_tag="BSU19740" /EC_number="2.6.1.48" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10839984, 15150230; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aminovalerate aminotransferase" /protein_id="NP_389855.1" /db_xref="EnsemblGenomes-Gn:BSU19740" /db_xref="EnsemblGenomes-Tr:CAB13865" /db_xref="GOA:O34662" /db_xref="InterPro:IPR005814" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG13546" /db_xref="UniProtKB/Swiss-Prot:O34662" /translation="MSSYLIKPELSSAYPVVSYAKGSYVYDQTGKKYLDGSSGAVTCN IGHGVRDVTEKLKEQLDQVSFAYRSQFTSEPAEQLAALLAQELPGDVNWSFFVNSGSE AIETAMKIAIQYWQEKKQTQKSIFLSRWSSYHGITLGALSLSGFYERRYRFTHLIERY PAISAPHIYRLNHETEEDFVQTAADELDTMIKRIGSQFIAGFVAEPIIGAAGAAITPP PGYYERLSEVCRTHDVLFIADEVMTGLGRTGRMLATEHWDTVPDIAVLGKGLGAGYAP IAAAVVSDSIIETIKQGSGVIMSGHTYSAHPYSAKAALEVLRYVLKHGLIKQSEKKGA VLKKKLDEAASQSGIIGEVRGKGLLLGIEFVADQKTKKVFPPEQAITQLIVSEAKKRG LIVYPSKAGIDSGEGDAVIIAPPFTISDGEMEELISIFSETVAAVEKNLKKD*" /label="yodT CDS" gene complement(1974962..1976296) /gene="yodT" /locus_tag="BSU_19740" /old_locus_tag="BSU19740" /label="yodT gene" CDS complement(1976277..1976432) /locus_tag="BSU_19745" /old_locus_tag="BSU19745" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_009513966.1" /translation="MLDAEISKEPSLLGRLFLCEKVFAGNVMPPFGHSYNMVKGVLRW EHEQLFD*" /label="conserved hypothetical protein CDS" gene complement(1976277..1976432) /locus_tag="BSU_19745" /old_locus_tag="BSU19745" /label="gene" promotor_-10 complement(1976315..1976333) /Source="Nicolas_upshift_promotors" /id="U1618" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1149 /SigmaFactorBS="aaggctctttttatgtgaaaaagtttttgcggggaacGTCAT GccgccatttggacacTCATACAATATGGTAAAAGgggttttgaggtgggagcatgag c" /listShort="yodT, yodS, yodR, yodQ, yodP, kamA, yokU, yozE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1976331) /Source="Nicolas_upshifts" /id="U1618" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1149 /SigmaFactorBS="aaggctctttttatgtgaaaaagtttttgcggggaacGTCAT GccgccatttggacacTCATACAATATGGTAAAAGgggttttgaggtgggagcatgag c" /listShort="yodT, yodS, yodR, yodQ, yodP, kamA, yokU, yozE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1976349..1976354) /Source="Nicolas_upshift_promotors" /id="U1618" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1149 /SigmaFactorBS="aaggctctttttatgtgaaaaagtttttgcggggaacGTCAT GccgccatttggacacTCATACAATATGGTAAAAGgggttttgaggtgggagcatgag c" /listShort="yodT, yodS, yodR, yodQ, yodP, kamA, yokU, yozE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1976426..1976659) /gene="yoyG" /locus_tag="BSU_19749" /old_locus_tag="BSU19749" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20156992, 21670523; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative toxin of a type I toxin family (sporulation operon)" /protein_id="YP_003097746.2" /db_xref="EnsemblGenomes-Gn:BSU19749" /db_xref="EnsemblGenomes-Tr:CAX52643" /db_xref="GOA:C0H435" /db_xref="InterPro:IPR010070" /db_xref="UniProtKB/Swiss-Prot:C0H435" /translation="MSGCILYFIISLHEIGVCTNHLGLGPHKMSYIVIRKDENSMYGY SGYGYGFGCGTNTFVLIVVLFILLIIVGAAFIC*" /label="yoyG CDS" gene complement(1976426..1976659) /gene="yoyG" /locus_tag="BSU_19749" /old_locus_tag="BSU19749" /label="yoyG gene" downshifts complement(1976433) /Source="Nicolas_upshifts" /id="D1086" /incds=0 /nref=96 /ntot=237 /MaxReadThrough="2.70127" /MaxDrop="7.98506" /score="25.3834194" /energy="-16.5" /TU="NA" /idTUdmin="U1620" /TUdmin="-14" /isTUend="TRUE" /label="downshifts" promotor_-35 1976535..1976539 /Source="Nicolas_upshift_promotors" /id="U1619" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=703 /SigmaFactorBS="agccaaatccgtaaccgtacccagagtatccaTACATgctgt tttCATCCTTTCTTATCAcgatatacgacattttatgcgggccaagtcccaaatggtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1976548..1976562 /Source="Nicolas_upshift_promotors" /id="U1619" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=703 /SigmaFactorBS="agccaaatccgtaaccgtacccagagtatccaTACATgctgt tttCATCCTTTCTTATCAcgatatacgacattttatgcgggccaagtcccaaatggtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1976563 /Source="Nicolas_upshifts" /id="U1619" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig=0 /xcortree=703 /SigmaFactorBS="agccaaatccgtaaccgtacccagagtatccaTACATgctgt tttCATCCTTTCTTATCAcgatatacgacattttatgcgggccaagtcccaaatggtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1976564..1976583) /Source="Nicolas_upshift_promotors" /id="U1620" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1350 /SigmaFactorBS="tatttccttacatgaaataggcgtttGCACAAACCAtttggg acttggccCGCATAAAATGTCGTATATCgtgataagaaaggatgaaaacagcatgtat g" /listShort="yoyG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1976573) /Source="Nicolas_upshifts" /id="U1620" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1350 /SigmaFactorBS="tatttccttacatgaaataggcgtttGCACAAACCAtttggg acttggccCGCATAAAATGTCGTATATCgtgataagaaaggatgaaaacagcatgtat g" /listShort="yoyG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1976598..1976607) /Source="Nicolas_upshift_promotors" /id="U1620" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1350 /SigmaFactorBS="tatttccttacatgaaataggcgtttGCACAAACCAtttggg acttggccCGCATAAAATGTCGTATATCgtgataagaaaggatgaaaacagcatgtat g" /listShort="yoyG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1976619..1977398) /gene="cgeE" /locus_tag="BSU_19750" /old_locus_tag="BSU19750" /function="16.5: Explore" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:1729246, 7592393, 10066829, 27260256" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1729246, 7592393, 10066829, 27260256; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="protein involved in maturation of the outermost layer of the spore" /protein_id="NP_389856.1" /db_xref="EnsemblGenomes-Gn:BSU19750" /db_xref="EnsemblGenomes-Tr:CAB13866" /db_xref="GOA:P42093" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG11197" /db_xref="UniProtKB/Swiss-Prot:P42093" /translation="MTGHYSKTEHQYILLTSESASFDHYSVYRDPQLPQIFSHNFVQL HDTFPLERLLNFLPSVPKLLDANYLHLKASPQHVFPLGLKQSLVKSGFVVEDELLYDM KLSDWKGQMGHPLTAWGTAKSLSDGSSIMKIYDSIYIGEAIAEQKLKRKYPFYEADII ILVVCYSDQAQKVPIGCGELFIDHQEKTAKIEEVAILDQFQRKGYGSILVKEMLSIAK SLGMEAAYLVAASTDGATQFYEKLTFKKYERVHTVFHYFLT*" /label="cgeE CDS" gene complement(1976619..1977398) /gene="cgeE" /locus_tag="BSU_19750" /old_locus_tag="BSU19750" /label="cgeE gene" CDS complement(1977427..1978707) /gene="cgeD" /locus_tag="BSU_19760" /old_locus_tag="BSU19760" /function="16.13: Shape" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:1729246, 10066829, 21665972" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1729246, 10066829, 21665972; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase involved in maturation of the outermost layer of the spore" /protein_id="NP_389857.1" /db_xref="EnsemblGenomes-Gn:BSU19760" /db_xref="EnsemblGenomes-Tr:CAB13867" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG11196" /db_xref="UniProtKB/Swiss-Prot:P42092" /translation="MGEKVSIILTSYNKPDYLQKAIESVIQQTHDLWELFIMDDHSNA ETTAVIHKYLHDRRIQYHNSFVHPADRLKTARYATLINSALPFADGDYISYLTDDTVY HPERLSRMVQEFSHKPEAQAVYSKQKVVHVNERGEEISHFYRNANAVLDQAAFQVDHC SVMHRRSLLNLIHHKFGGYWDDDMKHWNHGDAIFWARLNNFTPFLPINEVLDTTYKTP DSFQNAYRFLPADLIDGSFVKGSDQNVYFFDQGVRHPVGEKWGFLYLNRTVAVPDPYL FQYRIGKILNIPNYILVKEADHPAIFYIEAGKKRRIVDQYAFQFYQFQRKDIVTIGKE EMETLPEGPPITWKRSELIKNPPGRRLFFIEREPFLFLNGVFHPISEQVTRKFFLHQK PISASFRNIQQFPIGKPFYPVYDEIIKKLNIATE*" /label="cgeD CDS" gene complement(1977427..1978707) /gene="cgeD" /locus_tag="BSU_19760" /old_locus_tag="BSU19760" /label="cgeD gene" promotor_-10 complement(1978075..1978093) /Source="Nicolas_upshift_promotors" /id="U1621" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2789 /SigmaFactorBS="attggaatcatggcgacgcaattttttgggcgagactCAACA ACTttaccccatttctGCCGATAAATGAAGTATTAgacacaacctataaaaccccaga t" /listShort="cgeE, yoyG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1978091) /Source="Nicolas_upshifts" /id="U1621" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2789 /SigmaFactorBS="attggaatcatggcgacgcaattttttgggcgagactCAACA ACTttaccccatttctGCCGATAAATGAAGTATTAgacacaacctataaaaccccaga t" /listShort="cgeE, yoyG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1978107..1978114) /Source="Nicolas_upshift_promotors" /id="U1621" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2789 /SigmaFactorBS="attggaatcatggcgacgcaattttttgggcgagactCAACA ACTttaccccatttctGCCGATAAATGAAGTATTAgacacaacctataaaaccccaga t" /listShort="cgeE, yoyG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(1978675..1978693) /Source="Nicolas_upshift_promotors" /id="U1622" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=955 /SigmaFactorBS="ggagccgtttttatgtttgacggcgggaggcGGTATAgatgg gagagaaagtGTCTATTATTTTAACAAGTtacaacaaacccgattatttgcaaaaagc g" /listShort="cgeD, cgeE, yoyG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1978685) /Source="Nicolas_upshifts" /id="U1622" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=955 /SigmaFactorBS="ggagccgtttttatgtttgacggcgggaggcGGTATAgatgg gagagaaagtGTCTATTATTTTAACAAGTtacaacaaacccgattatttgcaaaaagc g" /listShort="cgeD, cgeE, yoyG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1978709..1978714) /Source="Nicolas_upshift_promotors" /id="U1622" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=955 /SigmaFactorBS="ggagccgtttttatgtttgacggcgggaggcGGTATAgatgg gagagaaagtGTCTATTATTTTAACAAGTtacaacaaacccgattatttgcaaaaagc g" /listShort="cgeD, cgeE, yoyG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1978772..1979077) /gene="cgeC" /locus_tag="BSU_19770" /old_locus_tag="BSU19770" /function="16.5: Explore" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:1729246, 10066829, 21665972" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1729246, 10066829, 21665972; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="protein involved in maturation of the outermost layer of the spore" /protein_id="NP_389858.1" /db_xref="EnsemblGenomes-Gn:BSU19770" /db_xref="EnsemblGenomes-Tr:CAB13868" /db_xref="SubtiList:BG11195" /db_xref="UniProtKB/Swiss-Prot:P42091" /translation="MDLEKQVDREENQDDLHFILLLLILLIRQSSSEGNPSDLRRQLV FAKELGVPVSKVNLINGDTLQNVIVKEVLTDLVIFQNPLNNTRSHVSLSSVVSWGAF* " /label="cgeC CDS" gene complement(1978772..1979077) /gene="cgeC" /locus_tag="BSU_19770" /old_locus_tag="BSU19770" /label="cgeC gene" downshifts complement(1978905) /Source="Nicolas_upshifts" /id="D1087" /incds=1 /nref=2 /ntot=28 /MaxReadThrough="5.32389" /MaxDrop="2.61092" /score="23.1569137" /energy="-13.4" /TU="U1623" /idTUdmin="U1623" /TUdmin="-2310" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1979101..1979120) /Source="Nicolas_upshift_promotors" /id="U1623" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1417 /SigmaFactorBS="ggaaaatgctgattttttaatggagtggacataGCCTATACC AtaaatcgaagtcgCACATATTGTGAAACAGAGAtaaggataagggagagggatgatt t" /listShort="cgeC, cgeD, cgeE" /listLong="yoyG" /label="promotor_-10" upshifts complement(1979116) /Source="Nicolas_upshifts" /id="U1623" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1417 /SigmaFactorBS="ggaaaatgctgattttttaatggagtggacataGCCTATACC AtaaatcgaagtcgCACATATTGTGAAACAGAGAtaaggataagggagagggatgatt t" /listShort="cgeC, cgeD, cgeE" /listLong="yoyG" /label="upshifts" promotor_-35 complement(1979134..1979143) /Source="Nicolas_upshift_promotors" /id="U1623" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1417 /SigmaFactorBS="ggaaaatgctgattttttaatggagtggacataGCCTATACC AtaaatcgaagtcgCACATATTGTGAAACAGAGAtaaggataagggagagggatgatt t" /listShort="cgeC, cgeD, cgeE" /listLong="yoyG" /label="promotor_-35" promotor_-35 1979213..1979222 /Source="Nicolas_upshift_promotors" /id="U1624" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1410 /SigmaFactorBS="cttaaatagatgaaaaatagatcaggtacggcgttcgACTCA TACCAaataacagccggaAGAATATGAATAACGTGAGTtcactatcgaataggaggtg t" /listShort="cgeA, cgeB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1979236..1979255 /Source="Nicolas_upshift_promotors" /id="U1624" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1410 /SigmaFactorBS="cttaaatagatgaaaaatagatcaggtacggcgttcgACTCA TACCAaataacagccggaAGAATATGAATAACGTGAGTtcactatcgaataggaggtg t" /listShort="cgeA, cgeB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1979236 /Source="Nicolas_upshifts" /id="U1624" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1410 /SigmaFactorBS="cttaaatagatgaaaaatagatcaggtacggcgttcgACTCA TACCAaataacagccggaAGAATATGAATAACGTGAGTtcactatcgaataggaggtg t" /listShort="cgeA, cgeB" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(1979257) /Source="Nicolas_upshifts" /id="U1625" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=1242 /SigmaFactorBS="taaatccttttttaactgtgcattttcagagCTCATtacaca caCCTCCTATTCGATAGtgaactcacgttattcatattcttccggctgttatttggta t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(1979259..1979273) /Source="Nicolas_upshift_promotors" /id="U1625" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=1242 /SigmaFactorBS="taaatccttttttaactgtgcattttcagagCTCATtacaca caCCTCCTATTCGATAGtgaactcacgttattcatattcttccggctgttatttggta t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(1979282..1979286) /Source="Nicolas_upshift_promotors" /id="U1625" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=1242 /SigmaFactorBS="taaatccttttttaactgtgcattttcagagCTCATtacaca caCCTCCTATTCGATAGtgaactcacgttattcatattcttccggctgttatttggta t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1979282..1979683 /gene="cgeA" /locus_tag="BSU_19780" /old_locus_tag="BSU19780" /function="16.5: Explore" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:759239, 14702409, 15621419, 19933362, 21665972" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 759239, 14702409, 15621419, 19933362, 21665972; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore outermost layer component" /protein_id="NP_389859.1" /db_xref="EnsemblGenomes-Gn:BSU19780" /db_xref="EnsemblGenomes-Tr:CAB13869" /db_xref="SubtiList:BG11193" /db_xref="UniProtKB/Swiss-Prot:P42089" /translation="MSSENAQLKKDLIKAVLSPLFPTATEGGENMDSNLKALLDAAID QKVDESETVTAESILDPSLPARWIFARITPGTTISIVTDSGDMIGPVVFVAFDQVHGI VFVTQESSVTPAGQATTLIDVDKVESVTFFS*" /label="cgeA CDS" gene 1979282..1979683 /gene="cgeA" /locus_tag="BSU_19780" /old_locus_tag="BSU19780" /label="cgeA gene" CDS 1979690..1980643 /gene="cgeB" /locus_tag="BSU_19790" /old_locus_tag="BSU19790" /function="16.8: Protect" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1729246, 10066829, 21665972" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1729246, 10066829, 21665972; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="protein involved in maturation of the outermost layer of the spore" /protein_id="NP_389860.2" /db_xref="EnsemblGenomes-Gn:BSU19790" /db_xref="EnsemblGenomes-Tr:CAB13870" /db_xref="InterPro:IPR024542" /db_xref="SubtiList:BG11194" /db_xref="UniProtKB/Swiss-Prot:P42090" /translation="MKVLYIQSGYGGIYSYFDRWAEECFQNTHTEYMIADKPEAESLM KIEAFQPDFTLMMVGDRVPHDWLTWLKGKDIPVYVWLTEDPFYMDISLQVIKLADAIL TIEQNAALYYQELGYQNVYYVPIPVNHRLFKKMGTEHSYHSNLLIIGYPYPNRVQLMK EAVHLPFTVRVIGKEWGKYLPKKVLKQPHIDVVSTWVPPEQAVHYYNGADIVINAHRP YHFAFNQNTMRIKNASFNNRTFDIAACEAFQLTDLPAAHPFSSIISYHGMNDFKEKAA FYINHPEERQKAAAANYKETVPAFTFDELPAKLKAIHLALS*" /label="cgeB CDS" gene 1979690..1980643 /gene="cgeB" /locus_tag="BSU_19790" /old_locus_tag="BSU19790" /label="cgeB gene" downshifts 1980633 /Source="Nicolas_upshifts" /id="D1088" /incds=0 /nref=4 /ntot=33 /MaxReadThrough="2.94229" /MaxDrop="5.87549" /score="22.1420541" /energy="-9" /TU="NA" /idTUdmin="U1624" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1980714..1981862) /gene="phyC" /locus_tag="BSU_19800" /old_locus_tag="BSU19800" /EC_number="3.1.3.8" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10679209, 12101298, 12111145, 12556126, 16980498, 17269748, 21463636" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10679209, 12101298, 12111145, 12556126, 16980498, 17269748, 21463636; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phytase" /protein_id="NP_389861.1" /db_xref="EnsemblGenomes-Gn:BSU19800" /db_xref="EnsemblGenomes-Tr:CAB13871" /db_xref="GOA:P42094" /db_xref="InterPro:IPR003431" /db_xref="InterPro:IPR011042" /db_xref="SubtiList:BG11198" /db_xref="UniProtKB/Swiss-Prot:P42094" /translation="MKVPKTMLLSTAAGLLLSLTATSVSAHYVNEEHHFKVTAHTETD PVASGDDAADDPAIWVHEKHPEKSKLITTNKKSGLVVYDLDGKQLHSYEFGKLNNVDL RYDFPLNGEKIDIAAASNRSEGKNTIEVYAIDGDKGKLKSITDPNHPISTNISEVYGF SLYHSQKTGAFYALVTGKQGEFEQYEIVDGGKGYVTGKKVREFKLNSQTEGLVADDEY GNLYIAEEDEAIWKFNAEPGGGSKGQVVDRATGDHLTADIEGLTIYYAPNGKGYLMAS SQGNNSYAMYERQGKNRYVANFEITDGEKIDGTSDTDGIDVLGFGLGPKYPYGIFVAQ DGENIDNGQAVNQNFKIVSWEQIAQHLGEMPDLHKQVNPRKLKDRSDG*" /label="phyC CDS" gene complement(1980714..1981862) /gene="phyC" /locus_tag="BSU_19800" /old_locus_tag="BSU19800" /label="phyC gene" downshifts complement(1980731) /Source="Nicolas_upshifts" /id="D1089" /incds=0 /nref=16 /ntot=104 /MaxReadThrough="2.64059" /MaxDrop="5.59857" /score="17.7154517" /energy="-8.7" /TU="NA" /idTUdmin="U1629" /TUdmin=2024 /isTUend="FALSE" /label="downshifts" promotor_-35 1981875..1981879 /Source="Nicolas_upshift_promotors" /id="U1627" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.642357642357642" /psig="0.988011988011988" /xcortree=1704 /SigmaFactorBS="tgtttttggaaccttcatttggtaccctccTCTTTtatcact aacactacTATTGTAAAATATATACAGGtgattaccgtgaggaaaatgaacctttttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(1981888..1981907) /Source="Nicolas_upshift_promotors" /id="U1626" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.619380619380619" /psig="0.994005994005994" /xcortree=564 /SigmaFactorBS="cagaaaccctataaaaaaaggttcattttcctcacggtaatc acctgtatATATTTTACAATAGTAGTGTtagtgataaaagaggagggtaccaaatgaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 1981895..1981914 /Source="Nicolas_upshift_promotors" /id="U1627" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.642357642357642" /psig="0.988011988011988" /xcortree=1704 /SigmaFactorBS="tgtttttggaaccttcatttggtaccctccTCTTTtatcact aacactacTATTGTAAAATATATACAGGtgattaccgtgaggaaaatgaacctttttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1981897) /Source="Nicolas_upshifts" /id="U1626" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.619380619380619" /psig="0.994005994005994" /xcortree=564 /SigmaFactorBS="cagaaaccctataaaaaaaggttcattttcctcacggtaatc acctgtatATATTTTACAATAGTAGTGTtagtgataaaagaggagggtaccaaatgaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts 1981905 /Source="Nicolas_upshifts" /id="U1627" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.642357642357642" /psig="0.988011988011988" /xcortree=1704 /SigmaFactorBS="tgtttttggaaccttcatttggtaccctccTCTTTtatcact aacactacTATTGTAAAATATATACAGGtgattaccgtgaggaaaatgaacctttttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 1982166..1982174 /Source="Nicolas_upshift_promotors" /id="U1628" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.867132867132867" /psig="0.867132867132867" /xcortree=1422 /SigmaFactorBS="atcattcccctaaattttgttttattggttgctttCATTAAT TCgattacaaagttgAACATATGATGCATGGTAGAgaaacgagagttggaggataagc c" /listShort="ypqP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 1982188..1982207 /Source="Nicolas_upshift_promotors" /id="U1628" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.867132867132867" /psig="0.867132867132867" /xcortree=1422 /SigmaFactorBS="atcattcccctaaattttgttttattggttgctttCATTAAT TCgattacaaagttgAACATATGATGCATGGTAGAgaaacgagagttggaggataagc c" /listShort="ypqP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 1982191 /Source="Nicolas_upshifts" /id="U1628" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.867132867132867" /psig="0.867132867132867" /xcortree=1422 /SigmaFactorBS="atcattcccctaaattttgttttattggttgctttCATTAAT TCgattacaaagttgAACATATGATGCATGGTAGAgaaacgagagttggaggataagc c" /listShort="ypqP" /GFF_Attribute="listLong" /label="upshifts" CDS 1982232..1983257 /NCBI_locus_tag="A8O17_RS10335" /NCBI_old_locus_tag="A8O17_10335" /inference="COORDINATES: similar to AA sequence:RefSeq:WP_014664318.1" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /codon_start=1 /transl_table=11 /product="polysaccharide biosynthesis protein" /protein_id="WP_003230816.1" /locus_tag="Delta6_BSU_19810-BSU_21670" /modified_by="User" /translation="MPKQQTAELKPFFHNKTVLVTGGTGSIGSQIVKRLLMLTPKQVI VFSKDDSKQYVMSQKYAEDKRLLFVLGDVRDHRRVNQVMKGVDIVFHAAALKQVPTCE DHPFEAIQTNLIGGQNVVEAALSHRVQHVINISTDKAVSPVNTMGATKLLSEKLFHQA NRHVQNKGTLFCSVRFGNVLGSRGSVIPILFEQMMEGEPLTITDKNMTRFFMSIDDAA TLTLQSAAITKGGETFIFKMESLKLEELIHGFEEYASQHGLPRPAAVEVGKRPGEKLH EELTSPHEIESLYEWGNLYAILPEPEKHPDFRKVNLPGYQSDQAPLITKERIAQIIEE LHQEKKA*" /label="Delta6_BSU_19810-BSU_21670" gene 1982232..1983257 /NCBI_locus_tag="A8O17_RS10335" /NCBI_old_locus_tag="A8O17_10335" /locus_tag="Delta6_BSU_19810-BSU_21670" /modified_by="User" /label="Delta6_BSU_19810-BSU_21670" downshifts 1982635 /Source="Nicolas_upshifts" /id="D1090" /incds=0 /nref=18 /ntot=39 /MaxReadThrough="0.75679" /MaxDrop="7.79081" /score="-6.65536786" /energy="-8.7" /TU="NA" /idTUdmin="U1628" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 <1982637..1982641 /Source="Nicolas_upshift_promotors" /id="U1702" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1418 /SigmaFactorBS="tttcatttttgacctcacagccactaATAGTTTCCActaaga aaagtagTAAGTATCTTAAAAAACAGAtaaagctgtatctcctgtgaacacaatgggt g" /listShort="ypqP" /GFF_Attribute="listLong" /label="promotor_-10" SCAR 1982651..1982652 /created_by="User" /note="deletion occured in betwen marked nucleotides" /modified_by="User" /label="Delta_SP_beta" downshifts 1983249 /Source="Nicolas_upshifts" /id="D1134" /incds=0 /nref=22 /ntot=177 /MaxReadThrough="2.90949" /MaxDrop="5.54327" /score="-2.31796312" /energy="-13.5" /TU="NA" /idTUdmin="U1701" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1983301..1983732) /gene="msrB" /locus_tag="BSU_21680" /old_locus_tag="BSU21680" /EC_number="1.8.4.12" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15680230, 16803968, 17031545, 18239417, 18662407; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peptide methionine R-sulfoxide reductase" /protein_id="NP_390051.1" /db_xref="EnsemblGenomes-Gn:BSU21680" /db_xref="EnsemblGenomes-Tr:CAB14086" /db_xref="GOA:P54155" /db_xref="InterPro:IPR002579" /db_xref="InterPro:IPR011057" /db_xref="InterPro:IPR028427" /db_xref="PDB:2KZN" /db_xref="PDB:3E0O" /db_xref="SubtiList:BG11628" /db_xref="UniProtKB/Swiss-Prot:P54155" /translation="MAYNKEEKIKSLNRMQYEVTQNNGTEPPFQNEYWDHKEEGLYVD IVSGKPLFTSKDKFDSQCGWPSFTKPIEEEVEEKLDTSHGMIRTEVRSRTADSHLGHV FNDGPGPNGLRYCINSAALRFVPKHKLKEEGYESYLHLFNK*" /label="msrB CDS" gene complement(1983301..1983732) /gene="msrB" /locus_tag="BSU_21680" /old_locus_tag="BSU21680" /label="msrB gene" downshifts complement(1983306) /Source="Nicolas_upshifts" /id="D1135" /incds=0 /nref=229 /ntot=262 /MaxReadThrough="2.46559" /MaxDrop="6.77483" /score="1.42817565" /energy="-12.3" /TU="NA" /idTUdmin="U1704" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" CDS complement(1983733..1984266) /gene="msrA" /locus_tag="BSU_21690" /old_locus_tag="BSU21690" /EC_number="1.8.4.11" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9573155, 16803968, 17062561, 18662407" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9573155, 16803968, 17062561, 18662407; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peptide methionine S-sulfoxide reductase" /protein_id="NP_390052.1" /db_xref="EnsemblGenomes-Gn:BSU21690" /db_xref="EnsemblGenomes-Tr:CAB14087" /db_xref="GOA:P54154" /db_xref="InterPro:IPR002569" /db_xref="InterPro:IPR036509" /db_xref="SubtiList:BG11627" /db_xref="UniProtKB/Swiss-Prot:P54154" /translation="MSEKKEIATFAGGCFWCMVKPFDEQPGIEKVVSGYTGGHTENPT YEEVCSETTGHREAVQITFHPDVFPYEKLLELFWQQIDPTDAGGQFADRGSSYRAAIF YHNDKQKELAEASKQRLAESGIFKDPIVTDILKAEPFYEAEGYHQHFYKKNPAHYQRY RTGSGRAGFISEHWGAK*" /label="msrA CDS" gene complement(1983733..1984266) /gene="msrA" /locus_tag="BSU_21690" /old_locus_tag="BSU21690" /label="msrA gene" promotor_-35 1984270..1984276 /Source="Nicolas_upshift_promotors" /id="U1703" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.648351648351648" /psig="0.946053946053946" /xcortree=3087 /SigmaFactorBS="agcctcctgcaaatgtggcgatttcttttttttcagacatac tGGTGCCTcctttgttaataCGTGGTATTATTATATTATAgcatgtaaaaatagaatg a" /listShort="S817, ypoP, S818" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1984287..1984397 /Source="Nicolas_S_feature" /locus_tag="new_2288083_2288193" /HighExp="B60, Lbstat, Cold, M9-stat, T4.0H, LoTm, S0, T3.30H, BC, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.946" /TUlongSig="NA" /TUlongPSig="NA" /label="S817" upshifts 1984287 /Source="Nicolas_upshifts" /id="U1703" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.648351648351648" /psig="0.946053946053946" /xcortree=3087 /SigmaFactorBS="agcctcctgcaaatgtggcgatttcttttttttcagacatac tGGTGCCTcctttgttaataCGTGGTATTATTATATTATAgcatgtaaaaatagaatg a" /listShort="S817, ypoP, S818" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1984289..1984308 /Source="Nicolas_upshift_promotors" /id="U1703" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.648351648351648" /psig="0.946053946053946" /xcortree=3087 /SigmaFactorBS="agcctcctgcaaatgtggcgatttcttttttttcagacatac tGGTGCCTcctttgttaataCGTGGTATTATTATATTATAgcatgtaaaaatagaatg a" /listShort="S817, ypoP, S818" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(1984294..1984313) /Source="Nicolas_upshift_promotors" /id="U1704" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig=1 /xcortree=2072 /SigmaFactorBS="gcatattgcttaaaacctatagattttattgaaaagcagaat caTTttcattctatttttaCATGCTATAATATAATAATAccacgtattaacaaaggag g" /listShort="msrA, msrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1984314) /Source="Nicolas_upshifts" /id="U1704" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig=1 /xcortree=2072 /SigmaFactorBS="gcatattgcttaaaacctatagattttattgaaaagcagaat caTTttcattctatttttaCATGCTATAATATAATAATAccacgtattaacaaaggag g" /listShort="msrA, msrB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1984329..1984330) /Source="Nicolas_upshift_promotors" /id="U1704" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.762237762237762" /psig=1 /xcortree=2072 /SigmaFactorBS="gcatattgcttaaaacctatagattttattgaaaagcagaat caTTttcattctatttttaCATGCTATAATATAATAATAccacgtattaacaaaggag g" /listShort="msrA, msrB" /GFF_Attribute="listLong" /label="promotor_-35" CDS 1984398..1984823 /gene="ypoP" /locus_tag="BSU_21700" /old_locus_tag="BSU21700" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9571784, 10809700; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MarR family)" /protein_id="NP_390053.1" /db_xref="EnsemblGenomes-Gn:BSU21700" /db_xref="EnsemblGenomes-Tr:CAB14088" /db_xref="GOA:P54182" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11626" /db_xref="UniProtKB/Swiss-Prot:P54182" /translation="MKVRTQMMYDMETLLRKVFKQIRNEINEILDKELSRNEFTILRI LSEQGPKKVTEFAPILEVSASHITAVTDALVEKEWITRIRSKEDRRIIRIHITEAGEK VLQHFNEKKTEYFFKRFDCYTDAELATLIELFSKLDKKR*" /label="ypoP CDS" gene 1984398..1984823 /gene="ypoP" /locus_tag="BSU_21700" /old_locus_tag="BSU21700" /label="ypoP gene" downshifts 1984811 /Source="Nicolas_upshifts" /id="D1136" /incds=0 /nref=92 /ntot=248 /MaxReadThrough="4.04021" /MaxDrop="5.35086" /score="-1.90494373" /energy="-7" /TU="U1703" /idTUdmin="U1703" /TUdmin="-1254" /isTUend="FALSE" /label="downshifts" S_feature 1984856..1986087 /Source="Nicolas_S_feature" /locus_tag="new_2288652_2289883" /HighExp="Cold, ferm, nit, C30, S0, Lbstat, T3.30H, T-4.40H, T5.0H, G135" /AntisenseName="dinF" /AntisenseCor="0.270994122332881" /AntisenseRegPval="-5.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.946" /TUlongSig="NA" /TUlongPSig="NA" /label="S818" CDS complement(1984873..1986210) /gene="dinF" /locus_tag="BSU_21710" /old_locus_tag="BSU21710" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11583854, 15849754, 16850406, 22933559, 26246409; Product type t : transporter" /codon_start=1 /transl_table=11 /product="damage inducible, Na+ driven multidrug efflux pump" /protein_id="NP_390054.1" /db_xref="EnsemblGenomes-Gn:BSU21710" /db_xref="EnsemblGenomes-Tr:CAB14089" /db_xref="GOA:P54181" /db_xref="InterPro:IPR002528" /db_xref="SubtiList:BG11625" /db_xref="UniProtKB/Swiss-Prot:P54181" /translation="MKAYDFTQGNVLKQLVLFSMPIMLGNALQVSFQFIDSLWIGNLL GAKALGAAAVSSTIVLTVLSFILGLNNATLTILSQQKGKDDIKGMASYINAFVVLLTG LSIGFGAAGFFLSELLLRLLKTPESMIPLAETYLQIQFIGILFLFGYNFISTVLRALG DSKTPLRFIAFAVVLNTVLAPLFISVFRMGIAGAAYSTILSQGIAFLYGLFYVIKHKL VPFSIPRMPKWEESALILKLGIPAGLQMMVITGGMMAIMSVVNSYGDHVVSGFGAVQR LDSIITLPAMAAGTAVNSMAGQNIGIGNEKRVGTIARLGVIAVISCMLVIAVMIWVFG KYLIRLFISEPDAVAFGEQYLKWIAFFYPFIGVNFVLNGIVRAAGAMLQVLVLNLISF WVLRYPFTALFSAWLGQKGIGLGIGMSFLFSSCAAFLYYRYGRWKAMKLFTEK*" /label="dinF CDS" gene complement(1984873..1986210) /gene="dinF" /locus_tag="BSU_21710" /old_locus_tag="BSU21710" /label="dinF gene" CDS complement(1986282..1986476) /gene="ypmT" /locus_tag="BSU_21720" /old_locus_tag="BSU21720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_390055.1" /db_xref="EnsemblGenomes-Gn:BSU21720" /db_xref="EnsemblGenomes-Tr:CAB14090" /db_xref="GOA:P54180" /db_xref="InterPro:IPR035403" /db_xref="SubtiList:BG11624" /db_xref="UniProtKB/Swiss-Prot:P54180" /translation="MKRIYQYFSLLSFTFSLYFGWLAYHHLAAEDMDQMYLNVSYCAL FLSVMVFTFGMRDRKKTDKS*" /label="ypmT CDS" gene complement(1986282..1986476) /gene="ypmT" /locus_tag="BSU_21720" /old_locus_tag="BSU21720" /label="ypmT gene" downshifts complement(1986295) /Source="Nicolas_upshifts" /id="D1137" /incds=0 /nref=123 /ntot=248 /MaxReadThrough="3.84998" /MaxDrop="4.80224" /score="-2.26655222" /energy="-15.5" /TU="U1705" /idTUdmin="U1707" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(1986489..1987052) /gene="ypmS" /locus_tag="BSU_21730" /old_locus_tag="BSU21730" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390056.1" /db_xref="EnsemblGenomes-Gn:BSU21730" /db_xref="EnsemblGenomes-Tr:CAB14091" /db_xref="GOA:P54179" /db_xref="InterPro:IPR018672" /db_xref="SubtiList:BG11623" /db_xref="UniProtKB/Swiss-Prot:P54179" /translation="MNKWKRLFFILLAINFILAAGFVALVLLPGEQAQVKDASESEYG FQVTSTKESLAAFVNSYLNDKASNKLDYKVEIDDDVHVAGKIKAFSTSIDAFIAFEPT VKKNGDVELNVTKFSLGKLSIPISFVLNYMDSFYELPSFVHVHPGDKSIEVRLSEMPL TNGMYVKADKINLEKDEIEFSYYHPKQ*" /label="ypmS CDS" gene complement(1986489..1987052) /gene="ypmS" /locus_tag="BSU_21730" /old_locus_tag="BSU21730" /label="ypmS gene" CDS complement(1987062..1987829) /gene="ypmR" /locus_tag="BSU_21740" /old_locus_tag="BSU21740" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17220230; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative exported lipase/acylhydrolase (lipoprotein)" /protein_id="NP_390057.1" /db_xref="EnsemblGenomes-Gn:BSU21740" /db_xref="EnsemblGenomes-Tr:CAB14092" /db_xref="GOA:P40766" /db_xref="InterPro:IPR013830" /db_xref="InterPro:IPR036514" /db_xref="SubtiList:BG11022" /db_xref="UniProtKB/Swiss-Prot:P40766" /translation="MKLRIFSIMASLILLLTACTSIRTSSEGKQKAHETKTKEHIVIA AVGDSLTEGVGDPDGKGYVGKVADSIRSDKQVKTVDVKNYAVKGNRSDDLLEKLKDKK VQKGIKDADYVFFTIGGNDLMKILRQNFLQLTVEPFQEAEKPYEKRFEKIISEIRELN DHAELIYVSMYNPFTFTLSELNEINGVVTDWNHIAEKELKKDKHAKIVHIEDLFNQKS DSSRISEEDDFHPNGTGYSLIAKRVYQAIKKEGLPKE*" /label="ypmR CDS" gene complement(1987062..1987829) /gene="ypmR" /locus_tag="BSU_21740" /old_locus_tag="BSU21740" /label="ypmR gene" promotor_-10 complement(1987853..1987872) /Source="Nicolas_upshift_promotors" /id="U1705" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.735264735264735" /psig=1 /xcortree=2250 /SigmaFactorBS="aagtcagccagtacactcaagtaagctaagagactaggcaTT TGCAAAtcttctaaaaCATGATACACTTTCCACTAGtagaatgggaaggagcaacaag a" /listShort="ypmR, ypmS, ypmT, dinF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1987870) /Source="Nicolas_upshifts" /id="U1705" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.735264735264735" /psig=1 /xcortree=2250 /SigmaFactorBS="aagtcagccagtacactcaagtaagctaagagactaggcaTT TGCAAAtcttctaaaaCATGATACACTTTCCACTAGtagaatgggaaggagcaacaag a" /listShort="ypmR, ypmS, ypmT, dinF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1987883..1987890) /Source="Nicolas_upshift_promotors" /id="U1705" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.735264735264735" /psig=1 /xcortree=2250 /SigmaFactorBS="aagtcagccagtacactcaagtaagctaagagactaggcaTT TGCAAAtcttctaaaaCATGATACACTTTCCACTAGtagaatgggaaggagcaacaag a" /listShort="ypmR, ypmS, ypmT, dinF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1987907..1988488) /gene="scuA" /locus_tag="BSU_21750" /old_locus_tag="BSU21750" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10837475, 14680962, 14766920, 16305244, 19027886, 29131589" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10837475, 14680962, 14766920, 16305244, 19027886, 29131589; Product type f : factor" /codon_start=1 /transl_table=11 /product="assembly factor BSco of the Cu(A) site of cytochrome c oxidase" /protein_id="NP_390058.2" /db_xref="EnsemblGenomes-Gn:BSU21750" /db_xref="EnsemblGenomes-Tr:CAB14093" /db_xref="GOA:P54178" /db_xref="InterPro:IPR003782" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR036249" /db_xref="PDB:1ON4" /db_xref="PDB:1XZO" /db_xref="SubtiList:BG11622" /db_xref="UniProtKB/Swiss-Prot:P54178" /translation="MKVIKGLTAGLIFLFLCACGGQQIKDPLNYEVEPFTFQNQDGKN VSLESLKGEVWLADFIFTNCETICPPMTAHMTDLQKKLKAENIDVRIISFSVDPENDK PKQLKKFAANYPLSFDNWDFLTGYSQSEIEEFALKSFKAIVKKPEGEDQVIHQSSFYL VGPDGKVLKDYNGVENTPYDDIISDVKSASTLK*" /label="scuA CDS" gene complement(1987907..1988488) /gene="scuA" /locus_tag="BSU_21750" /old_locus_tag="BSU21750" /label="scuA gene" S_feature complement(1988489..1988604) /Source="Nicolas_S_feature" /locus_tag="new_2292285_2292400_c" /HighExp="T5.0H, T3.30H, S2, T3.0H, BC, T2.30H, T4.0H, S1, HiOs, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S819" CDS complement(1988636..1988887) /gene="ypmP" /locus_tag="BSU_21760" /old_locus_tag="BSU21760" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15060025, 22720735" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_390059.1" /db_xref="EnsemblGenomes-Gn:BSU21760" /db_xref="EnsemblGenomes-Tr:CAB14094" /db_xref="InterPro:IPR019687" /db_xref="SubtiList:BG11621" /db_xref="UniProtKB/Swiss-Prot:P54177" /translation="MLLKSLEFKRGDGIQVKVTEIPVLKEDEHYFFMLHHHLQFYLKE VFSSNSRAKVYSFRHYMKRRMKWADYQAVFHQEVLKHNA*" /label="ypmP CDS" gene complement(1988636..1988887) /gene="ypmP" /locus_tag="BSU_21760" /old_locus_tag="BSU21760" /label="ypmP gene" downshifts complement(1988649) /Source="Nicolas_upshifts" /id="D1138" /incds=0 /nref=2 /ntot=117 /MaxReadThrough="4.5803" /MaxDrop="2.91481" /score="26.0320926" /energy="-21.8" /TU="U1707" /idTUdmin="U1706" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(1988910..1988929) /Source="Nicolas_upshift_promotors" /id="U1706" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.896103896103896" /psig=1 /xcortree=626 /SigmaFactorBS="ttgctaatctaatttttttacacaaccgcgcaaaatgacaga cagcccggctggcATCATATATAATAGAAGAAAaacaaaaaagaggattgatagcttg t" /listShort="ypmP" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(1988924) /Source="Nicolas_upshifts" /id="U1706" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.896103896103896" /psig=1 /xcortree=626 /SigmaFactorBS="ttgctaatctaatttttttacacaaccgcgcaaaatgacaga cagcccggctggcATCATATATAATAGAAGAAAaacaaaaaagaggattgatagcttg t" /listShort="ypmP" /GFF_Attribute="listLong" /label="upshifts" CDS complement(1988973..1990241) /gene="ilvA" /locus_tag="BSU_21770" /old_locus_tag="BSU21770" /EC_number="4.3.1.19" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12618455, 13878122, 1459955, 15060025, 18855421, 22094463, 27260660" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12618455, 13878122, 1459955, 15060025, 18855421, 22094463, 27260660; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="threonine dehydratase" /protein_id="NP_390060.1" /db_xref="EnsemblGenomes-Gn:BSU21770" /db_xref="EnsemblGenomes-Tr:CAB14095" /db_xref="GOA:P37946" /db_xref="InterPro:IPR000634" /db_xref="InterPro:IPR001721" /db_xref="InterPro:IPR001926" /db_xref="InterPro:IPR011820" /db_xref="InterPro:IPR036052" /db_xref="SubtiList:BG10673" /db_xref="UniProtKB/Swiss-Prot:P37946" /translation="MKPLLKENSLIQVKDILKAHQNVKDVVIHTPLQRNDRLSERYEC NIYLKREDLQVVRSFKLRGAYHKMKQLSSEQTENGVVCASAGNHAQGVAFSCKHLGIH GKIFMPSTTPRQKVSQVELFGKGFIDIILTGDTFDDAYKSAAECCEAESRTFIHPFDD PDVMAGQGTLAVEILNDIDTEPHFLFASVGGGGLLSGVGTYLKNVSPDTKVIAVEPAG AASYFESNKAGHVVTLDKIDKFVDGAAVKKIGEETFRTLETVVDDILLVPEGKVCTSI LELYNECAVVAEPAGALSVAALDLYKDQIKGKNVVCVVSGGNNDIGRMQEMKERSLIF EGLQHYFIVNFPQRAGALREFLDEVLGPNDDITRFEYTKKNNKSNGPALVGIELQNKA DYGPLIERMNKKPFHYVEVNKDEDLFHLLI*" /label="ilvA CDS" gene complement(1988973..1990241) /gene="ilvA" /locus_tag="BSU_21770" /old_locus_tag="BSU21770" /label="ilvA gene" promotor_-10 complement(1990275..1990294) /Source="Nicolas_upshift_promotors" /id="U1707" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.754245754245754" /psig="0.999000999001" /xcortree=2906 /SigmaFactorBS="gacatagtctgtatttttttaattattaaataaaaataattG TCTTATTttttgaatattCATGTTATAATGGCATATTAaatagggatttaaaacaaga a" /listShort="ilvA, ypmP, S819, scuA, ypmR, ypmS, ypmT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1990294) /Source="Nicolas_upshifts" /id="U1707" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.754245754245754" /psig="0.999000999001" /xcortree=2906 /SigmaFactorBS="gacatagtctgtatttttttaattattaaataaaaataattG TCTTATTttttgaatattCATGTTATAATGGCATATTAaatagggatttaaaacaaga a" /listShort="ilvA, ypmP, S819, scuA, ypmR, ypmS, ypmT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1990306..1990313) /Source="Nicolas_upshift_promotors" /id="U1707" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.754245754245754" /psig="0.999000999001" /xcortree=2906 /SigmaFactorBS="gacatagtctgtatttttttaattattaaataaaaataattG TCTTATTttttgaatattCATGTTATAATGGCATATTAaatagggatttaaaacaaga a" /listShort="ilvA, ypmP, S819, scuA, ypmR, ypmS, ypmT" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 1990448..1990467 /Source="Nicolas_upshift_promotors" /id="U1708" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=3088 /SigmaFactorBS="cctgcagagccaagaaaaaagatgatcgtaaaataaagggtg ttttcaaccaaaaggCATGATATAATGAAACCAATtagaaccaaaaggagccaattga t" /listShort="yplP, yplQ, S820" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 1990451 /Source="Nicolas_upshifts" /id="U1708" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=3088 /SigmaFactorBS="cctgcagagccaagaaaaaagatgatcgtaaaataaagggtg ttttcaaccaaaaggCATGATATAATGAAACCAATtagaaccaaaaggagccaattga t" /listShort="yplP, yplQ, S820" /GFF_Attribute="listLong" /label="upshifts" CDS 1990490..1991485 /gene="silP" /locus_tag="BSU_21780" /old_locus_tag="BSU21780" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12399512, 16585774, 19763274" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12399512, 16585774, 19763274; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional enhancer involved in BCAA homeostasis" /protein_id="NP_390061.1" /db_xref="EnsemblGenomes-Gn:BSU21780" /db_xref="EnsemblGenomes-Tr:CAB14096" /db_xref="GOA:P54156" /db_xref="InterPro:IPR002078" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR013668" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11619" /db_xref="UniProtKB/Swiss-Prot:P54156" /translation="MNSAPKLNTFQHLIGEHQTFLEAKRIAKQFSLSELPVLITGKIG TGKNHFAHAIHLESSRSNEPFISVNCSTHSEETLIHELFGPNGNTGVFQKAVRGTLFL DDVWRMPASVQAQLLKALDSDTEKPRMICASADRSVEHTFRQDLFYRLNILTLTLPEL SERKSDIPLLTQHFLSNSGQQLLIDPSVFPVLEKHAFEGNVRELKNAADYMAAVSSGG TIQPYDLPPYIRGTIDGKTSKKKAKLLTLMEKAEFLFILETIKVLNEKGEPASRRIIS EHSKNTQTSLTPQQVRSRLDYLEKKDYVTKSRGRAGTKITFEGLSFIETLKNQMI*" /label="silP CDS" gene 1990490..1991485 /gene="silP" /locus_tag="BSU_21780" /old_locus_tag="BSU21780" /label="silP gene" CDS 1991506..1992147 /gene="yplQ" /locus_tag="BSU_21790" /old_locus_tag="BSU21790" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16585774, 16850406, 19763274; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane hydrolase" /protein_id="NP_390062.1" /db_xref="EnsemblGenomes-Gn:BSU21790" /db_xref="EnsemblGenomes-Tr:CAB14097" /db_xref="GOA:P54175" /db_xref="InterPro:IPR004254" /db_xref="InterPro:IPR005744" /db_xref="SubtiList:BG11620" /db_xref="UniProtKB/Swiss-Prot:P54175" /translation="MFTIKEEIANAITHGIGVLLSIPALVFLIIFAANYGSAWDIVSF TIFGVSMLLLYLSSTLLHSITHKKTKDILEIIDHSAIYVLIAGTYTPFLLGPLKGTLG FTLLVIVWSLALGGIVFKIFFVKRFILLSTFVYLVMGWLMIIAVKPLYASLSGAGFSL LFLGGILYSVGTIFYIWKKIPFHHAIWHSFVLGGSAAMFFCVLFYCVKVPFLS*" /label="yplQ CDS" gene 1991506..1992147 /gene="yplQ" /locus_tag="BSU_21790" /old_locus_tag="BSU21790" /label="yplQ gene" S_feature 1992148..1993249 /Source="Nicolas_S_feature" /locus_tag="new_2295944_2297045" /HighExp="Cold, C30, Sw, BC, G135, LoTm, Fru, C90, BI, S0" /AntisenseName="ypkP" /AntisenseCor="0.28434605181220002" /AntisenseRegPval="-5.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S820" CDS complement(1992186..1992806) /gene="ypkP" /locus_tag="BSU_21800" /old_locus_tag="BSU21800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 1-acyl-sn-glycerol-3-phosphate acyltransferase" /protein_id="NP_390063.2" /db_xref="EnsemblGenomes-Gn:BSU21800" /db_xref="EnsemblGenomes-Tr:CAB14098" /db_xref="SubtiList:BG11618" /db_xref="UniProtKB/Swiss-Prot:P54174" /translation="MVRYSLLVVYIVYMLLKNMKQLFNQTMLDPRLSYKKQMALVYEQ PKAFLEGCIGISGSVVTIHQPEPIPHGPVLYVHPRLRLAELALIAGYIEEPAGFIANP KVFRLPFIGQWLDRMDVISDGDSEKVYEDVTKQLEKGQSLILSLDGSIDPVELAARYH LPLVMVETKGTDNMQNGSFFKRLKPADIELSFSKAYIPANEKQLRA*" /label="ypkP CDS" gene complement(1992186..1992806) /gene="ypkP" /locus_tag="BSU_21800" /old_locus_tag="BSU21800" /label="ypkP gene" downshifts complement(1992212) /Source="Nicolas_upshifts" /id="D1139" /incds=0 /nref=72 /ntot=241 /MaxReadThrough="1.32187" /MaxDrop="5.02823" /score="16.0584527" /energy="-13.4" /TU="NA" /idTUdmin="U1710" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" CDS complement(1992807..1993313) /gene="dfrA" /locus_tag="BSU_21810" /old_locus_tag="BSU21810" /EC_number="1.5.1.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2840350, 3918568, 10574451, 12682299, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2840350, 3918568, 10574451, 12682299, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydrofolate reductase" /protein_id="NP_390064.1" /db_xref="EnsemblGenomes-Gn:BSU21810" /db_xref="EnsemblGenomes-Tr:CAB14099" /db_xref="GOA:P11045" /db_xref="InterPro:IPR001796" /db_xref="InterPro:IPR012259" /db_xref="InterPro:IPR017925" /db_xref="InterPro:IPR024072" /db_xref="SubtiList:BG10795" /db_xref="UniProtKB/Swiss-Prot:P11045" /translation="MISFIFAMDANRLIGKDNDLPWHLPNDLAYFKKITSGHSIIMGR KTFESIGRPLPNRKNIVVTSAPDSEFQGCTVVSSLKDVLDICSGPEECFVIGGAQLYT DLFPYADRLYMTKIHHEFEGDRHFPEFDESNWKLVSSEQGTKDEKNPYDYEFLMYEKK NSSKAGGF*" /label="dfrA CDS" gene complement(1992807..1993313) /gene="dfrA" /locus_tag="BSU_21810" /old_locus_tag="BSU21810" /label="dfrA gene" CDS complement(1993310..1994104) /gene="thyB" /locus_tag="BSU_21820" /old_locus_tag="BSU21820" /EC_number="2.1.1.45" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9648749, 10574451, 19732150" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9648749, 10574451, 19732150; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thymidylate synthase B" /protein_id="NP_390065.1" /db_xref="EnsemblGenomes-Gn:BSU21820" /db_xref="EnsemblGenomes-Tr:CAB14100" /db_xref="GOA:P11044" /db_xref="InterPro:IPR000398" /db_xref="InterPro:IPR020940" /db_xref="InterPro:IPR023451" /db_xref="InterPro:IPR036926" /db_xref="SubtiList:BG10794" /db_xref="UniProtKB/Swiss-Prot:P11044" /translation="MKQYKDFCRHVLEHGEKKGDRTGTGTISTFGYQMRFNLREGFPM LTTKKLHFKSIAHELLWFLKGDTNVRYLQENGVRIWNEWADENGELGPVYGSQWRSWR GADGETIDQISRLIEDIKTNPNSRRLIVSAWNVGEIDKMALPPCHCLFQFYVSDGKLS CQLYQRSADVFLGVPFNIASYALLTMIIAHVTGLEPGEFIHTFGDVHIYQNHIEQVNL QLERDVRPLPQLRFARKVDSIFNFAFEDFIIEDYDPHPHIKGAVSV*" /label="thyB CDS" gene complement(1993310..1994104) /gene="thyB" /locus_tag="BSU_21820" /old_locus_tag="BSU21820" /label="thyB gene" CDS complement(1994188..1994721) /gene="ypjQ" /locus_tag="BSU_21830" /old_locus_tag="BSU21830" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8534098; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphatidylglycerophosphatase" /protein_id="NP_390066.1" /db_xref="EnsemblGenomes-Gn:BSU21830" /db_xref="EnsemblGenomes-Tr:CAB14101" /db_xref="GOA:P54173" /db_xref="InterPro:IPR007686" /db_xref="InterPro:IPR026038" /db_xref="InterPro:IPR036681" /db_xref="PDB:1TLQ" /db_xref="SubtiList:BG11617" /db_xref="UniProtKB/Swiss-Prot:P54173" /translation="MKKYTMNEMVDITKDMLNKRGVMIEDIARIVQKLQEKYNPNLPL SVCMENVEKVLNKREIIHAVLTGLALDQLAEQKLLPEPLQHLVETDEPLYGIDEIIPL SIVNVYGSIGLTNFGYLDKEKIGIIKELDESPDGIHTFLDDIVAALAAAAASRIAHTH QDLQDEEKEQDEKPVVS*" /label="ypjQ CDS" gene complement(1994188..1994721) /gene="ypjQ" /locus_tag="BSU_21830" /old_locus_tag="BSU21830" /label="ypjQ gene" downshifts complement(1994193) /Source="Nicolas_upshifts" /id="D1140" /incds=0 /nref=17 /ntot=167 /MaxReadThrough="4.91561" /MaxDrop="4.18561" /score="15.5758445" /energy="-9.3" /TU="U1710" /idTUdmin="U1711" /TUdmin=1232 /isTUend="FALSE" /label="downshifts" promotor_-35 1994651..1994656 /Source="Nicolas_upshift_promotors" /id="U1709" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1113 /SigmaFactorBS="tatttttcctgaagtttttgaacaatccgtgcaatatcttct ATCATAacgccccgtttgttcaGCATATCCTTTGTTATATCgaccatttcattcattg t" /listShort="S821" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 1994667..1995613 /Source="Nicolas_S_feature" /locus_tag="new_2298463_2299409" /HighExp="S5, S6, S4, S8, S7, S3, B36, BT, B60, T5.0H" /AntisenseName="ypjP" /AntisenseCor="-0.72590712604537599" /AntisenseRegPval="-44.6" /CDS_PredictionProba="0.99932399999999999" /TUshortSig="SigEF" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S821" upshifts 1994669 /Source="Nicolas_upshifts" /id="U1709" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1113 /SigmaFactorBS="tatttttcctgaagtttttgaacaatccgtgcaatatcttct ATCATAacgccccgtttgttcaGCATATCCTTTGTTATATCgaccatttcattcattg t" /listShort="S821" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 1994673..1994691 /Source="Nicolas_upshift_promotors" /id="U1709" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1113 /SigmaFactorBS="tatttttcctgaagtttttgaacaatccgtgcaatatcttct ATCATAacgccccgtttgttcaGCATATCCTTTGTTATATCgaccatttcattcattg t" /listShort="S821" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(1994739..1995350) /gene="ypjP" /locus_tag="BSU_21840" /old_locus_tag="BSU21840" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_390067.1" /db_xref="EnsemblGenomes-Gn:BSU21840" /db_xref="EnsemblGenomes-Tr:CAB14102" /db_xref="GOA:P54172" /db_xref="InterPro:IPR025616" /db_xref="SubtiList:BG11616" /db_xref="UniProtKB/Swiss-Prot:P54172" /translation="MKLWMRKTLVVLFTIVTFGLVSPPAALMADKPSGQPSSLEQNDY TAFYDEHDLYDDESDDRRDPELLFQSYKEQLLDSAEDQSFLKFGSRIAPVIEDDYRKE ILPKIENVISDYLATLQDDEAYQDVVISSMPSAGKTEKIFNVYNRTTGEDLLRFHVRR DHPPHDGYWFNFHYHTAEDGFQSHHELGSIYWDRNTPPNWMSA*" /label="ypjP CDS" gene complement(1994739..1995350) /gene="ypjP" /locus_tag="BSU_21840" /old_locus_tag="BSU21840" /label="ypjP gene" promotor_-10 complement(1995382..1995401) /Source="Nicolas_upshift_promotors" /id="U1710" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2276 /SigmaFactorBS="gcaacgaatctcctaatttgcatatcagtttcatatagtaca TGACTTgcatgttttggaTGTGCTAAAATAAGAGAAACatgacaataaaatagagagg a" /listShort="ypjP, ypjQ, thyB, dfrA, ypkP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1995401) /Source="Nicolas_upshifts" /id="U1710" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2276 /SigmaFactorBS="gcaacgaatctcctaatttgcatatcagtttcatatagtaca TGACTTgcatgttttggaTGTGCTAAAATAAGAGAAACatgacaataaaatagagagg a" /listShort="ypjP, ypjQ, thyB, dfrA, ypkP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1995414..1995419) /Source="Nicolas_upshift_promotors" /id="U1710" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2276 /SigmaFactorBS="gcaacgaatctcctaatttgcatatcagtttcatatagtaca TGACTTgcatgttttggaTGTGCTAAAATAAGAGAAACatgacaataaaatagagagg a" /listShort="ypjP, ypjQ, thyB, dfrA, ypkP" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 1995570 /Source="Nicolas_upshifts" /id="D1141" /incds=0 /nref=57 /ntot=234 /MaxReadThrough="3.131" /MaxDrop="5.18613" /score="2.81720493" /energy="-15" /TU="U1709" /idTUdmin="U1709" /TUdmin="-527" /isTUend="FALSE" /label="downshifts" CDS complement(1995610..1996383) /gene="rsmJ" /locus_tag="BSU_21850" /old_locus_tag="BSU21850" /EC_number="2.1.1.242" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22079366; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 16S rRNA m(2)G1516 methyltransferase" /protein_id="NP_390068.2" /db_xref="EnsemblGenomes-Gn:BSU21850" /db_xref="EnsemblGenomes-Tr:CAB14103" /db_xref="GOA:P54171" /db_xref="InterPro:IPR007536" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11615" /db_xref="UniProtKB/Swiss-Prot:P54171" /translation="MITTSYRPSEHTIKTAKQLSKELNMPYCGRNKQTVEHLLKSAER DLLVVGKERFELYTKQGAKFFFHPNTAMFRAKRFLQGEKEPMLRAAGLSEGDTFLDCT LGLGSDAIIASMAVGETGSVVGIEKNHLVSVLVRTGLHSWETGIEELQAAMRRIQVKN GDCFEHIKQLPDNSVDVVYFDPMFHEPVETSDGIAPLRDLAEDSVLHEGCINEAVRVA RKSVVLKDHWKSPRFEQFGFNVMKRKTALFHYGVIQTSP*" /label="rsmJ CDS" gene complement(1995610..1996383) /gene="rsmJ" /locus_tag="BSU_21850" /old_locus_tag="BSU21850" /label="rsmJ gene" downshifts complement(1995645) /Source="Nicolas_upshifts" /id="D1142" /incds=0 /nref=1 /ntot=66 /MaxReadThrough="2.86923" /MaxDrop="2.91228" /score="9.10717118" /energy="-15" /TU="U1711" /idTUdmin="U1711" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" CDS complement(1996425..1996859) /gene="brxA" /locus_tag="BSU_21860" /old_locus_tag="BSU21860" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:19653655, 21749987, 22938038, 24313874, 28301954" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19653655, 21749987, 22938038, 24313874, 28301954; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein disulfide isomerase; bacilliredoxin A (de-bacillithiolation)" /protein_id="NP_390069.1" /db_xref="EnsemblGenomes-Gn:BSU21860" /db_xref="EnsemblGenomes-Tr:CAB14104" /db_xref="InterPro:IPR009474" /db_xref="PDB:3FHK" /db_xref="SubtiList:BG11614" /db_xref="UniProtKB/Swiss-Prot:P54170" /translation="MSMAYEEYMRQLVVPMRRELTGAGFEELTTAEEVENFMEKAEGT TLVVVNSVCGCAAGLARPAATQAVLQNDKTPDNTVTVFAGQDKEATAKMREYFTGQEP SSPSMALLKGKEVVHFIPRHEIEGHDMEEIMKNLTAAFDAHC*" /label="brxA CDS" gene complement(1996425..1996859) /gene="brxA" /locus_tag="BSU_21860" /old_locus_tag="BSU21860" /label="brxA gene" downshifts complement(1996437) /Source="Nicolas_upshifts" /id="D1143" /incds=0 /nref=9 /ntot=210 /MaxReadThrough="5.2935" /MaxDrop="3.1992" /score="21.0933404" /energy="-9.7" /TU="U1711,U1712" /idTUdmin="U1712" /TUdmin="-462" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(1996888..1996907) /Source="Nicolas_upshift_promotors" /id="U1711" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.972027972027972" /psig="0.997002997002997" /xcortree=1933 /SigmaFactorBS="ggggacactttcttttattttaaggcgtgaaCATTTGAAatc cggccctctcTATAGTATCCTTTACTTCAGatgaaggatactagagggggcttttttt a" /listShort="yphP, ypiP" /listLong="ypjP, ypjQ, thyB, dfrA, ypkP" /label="promotor_-10" upshifts complement(1996899) /Source="Nicolas_upshifts" /id="U1711" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.972027972027972" /psig="0.997002997002997" /xcortree=1933 /SigmaFactorBS="ggggacactttcttttattttaaggcgtgaaCATTTGAAatc cggccctctcTATAGTATCCTTTACTTCAGatgaaggatactagagggggcttttttt a" /listShort="yphP, ypiP" /listLong="ypjP, ypjQ, thyB, dfrA, ypkP" /label="upshifts" S_feature complement(1996901..1996965) /Source="Nicolas_S_feature" /locus_tag="new_2300697_2300761_c" /HighExp="Sw, S1, BC, Gly, HiOs, HiTm, GM-0.1, UNK1, Fru, MG 60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S822" promotor_-35 complement(1996921..1996928) /Source="Nicolas_upshift_promotors" /id="U1711" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.972027972027972" /psig="0.997002997002997" /xcortree=1933 /SigmaFactorBS="ggggacactttcttttattttaaggcgtgaaCATTTGAAatc cggccctctcTATAGTATCCTTTACTTCAGatgaaggatactagagggggcttttttt a" /listShort="yphP, ypiP" /listLong="ypjP, ypjQ, thyB, dfrA, ypkP" /label="promotor_-35" downshifts complement(1996944) /Source="Nicolas_upshifts" /id="D1144" /incds=0 /nref=32 /ntot=128 /MaxReadThrough="5.73826" /MaxDrop="4.95094" /score="26.9702838" /energy="-25.8" /TU="U1712" /idTUdmin="U1713" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(1996966..1998642) /gene="ilvD" /locus_tag="BSU_21870" /old_locus_tag="BSU21870" /EC_number="4.2.1.9" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12193635, 12618455, 15060025, 24163341" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12193635, 12618455, 15060025, 24163341; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydroxy-acid dehydratase" /protein_id="NP_390070.2" /db_xref="EnsemblGenomes-Gn:BSU21870" /db_xref="EnsemblGenomes-Tr:CAB14105" /db_xref="GOA:P51785" /db_xref="InterPro:IPR000581" /db_xref="InterPro:IPR004404" /db_xref="InterPro:IPR015928" /db_xref="InterPro:IPR020558" /db_xref="SubtiList:BG11532" /db_xref="UniProtKB/Swiss-Prot:P51785" /translation="MAELRSNMITQGIDRAPHRSLLRAAGVKEEDFGKPFIAVCNSYI DIVPGHVHLQEFGKIVKEAIREAGGVPFEFNTIGVDDGIAMGHIGMRYSLPSREIIAD SVETVVSAHWFDGMVCIPNCDKITPGMLMAAMRINIPTIFVSGGPMAAGRTSDGRKIS LSSVFEGVGAYQAGKINENELQELEQFGCPTCGSCSGMFTANSMNCLSEALGLALPGN GTILATSPERKEFVRKSAAQLMETIRKDIKPRDIVTVKAIDNAFALDMALGGSTNTVL HTLALANEAGVEYSLERINEVAERVPHLAKLAPASDVFIEDLHEAGGVSAALNELSKK EGALHLDALTVTGKTLGETIAGHEVKDYDVIHPLDQPFTEKGGLAVLFGNLAPDGAII KTGGVQNGITRHEGPAVVFDSQDEALDGIINRKVKEGDVVIIRYEGPKGGPGMPEMLA PTSQIVGMGLGPKVALITDGRFSGASRGLSIGHVSPEAAEGGPLAFVENGDHIIVDIE KRILDVQVPEEEWEKRKANWKGFEPKVKTGYLARYSKLVTSANTGGIMKI*" /label="ilvD CDS" gene complement(1996966..1998642) /gene="ilvD" /locus_tag="BSU_21870" /old_locus_tag="BSU21870" /label="ilvD gene" S_feature complement(1998643..1998833) /Source="Nicolas_S_feature" /locus_tag="new_2302439_2302629_c" /HighExp="S1, T-5.40H, MG 45, HiOs, T-4.40H, MG 120, UNK1, MG 25, MG-0.2, GM-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 0.97" /TUlongSig="SigH" /TUlongPSig=1 /label="S823" promotor_-10 complement(1998822..1998841) /Source="Nicolas_upshift_promotors" /id="U1712" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.555444555444555" /psig="0.997002997002997" /xcortree=2910 /SigmaFactorBS="gaattcactttttataaaaattatttcgaatattGTTGaaaa atatccgaaaACTATTTATAGTAAGTAACAatattaatagttggagggttcaaatcga a" /listShort="S823, ilvD, S822, yphP, ypiP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(1998833) /Source="Nicolas_upshifts" /id="U1712" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.555444555444555" /psig="0.997002997002997" /xcortree=2910 /SigmaFactorBS="gaattcactttttataaaaattatttcgaatattGTTGaaaa atatccgaaaACTATTTATAGTAAGTAACAatattaatagttggagggttcaaatcga a" /listShort="S823, ilvD, S822, yphP, ypiP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(1998856..1998859) /Source="Nicolas_upshift_promotors" /id="U1712" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.555444555444555" /psig="0.997002997002997" /xcortree=2910 /SigmaFactorBS="gaattcactttttataaaaattatttcgaatattGTTGaaaa atatccgaaaACTATTTATAGTAAGTAACAatattaatagttggagggttcaaatcga a" /listShort="S823, ilvD, S822, yphP, ypiP" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(1998931..2000064) /gene="ypgR" /locus_tag="BSU_21880" /old_locus_tag="BSU21880" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative lyase or scaffold" /protein_id="NP_390071.1" /db_xref="EnsemblGenomes-Gn:BSU21880" /db_xref="EnsemblGenomes-Tr:CAB14106" /db_xref="InterPro:IPR004155" /db_xref="InterPro:IPR014824" /db_xref="InterPro:IPR016024" /db_xref="InterPro:IPR025989" /db_xref="InterPro:IPR036498" /db_xref="SubtiList:BG11613" /db_xref="UniProtKB/Swiss-Prot:P54169" /translation="MKIKSIEPTPSPNTMKVILTEELPAGKSNNYKPEQAEGAPLVIA EILKIDGVKGVYHVADFLAVERNARYDWKDILPQVRTAFGMESAESAEENRSDQESFG EVKVFVQMFSGIPMQVKLTDGEREERFGLPERFQQAILKLRSEASNVVFERAWKEQGV RFGDFDEIGHDVTEELQAAYSDERLKRLTEAAAQGKGEAKQAVQRKAYKVTLDMLDDE DWKKRYAHLEQMDPKEEDIPVLQKALDDPKVSIRRQAVVYLGMIETPDVLPLLYKALE DKAVSVRRTAGDCLSDIGDPQAIPAMIKSLSDSSKLVRWRAAMFLYEVGDESAIEALR AAEDDPEFEVSLQVKMALERIEHGEEAKGSVWKQMTESRKKGE*" /label="ypgR CDS" gene complement(1998931..2000064) /gene="ypgR" /locus_tag="BSU_21880" /old_locus_tag="BSU21880" /label="ypgR gene" downshifts complement(1998947) /Source="Nicolas_upshifts" /id="D1145" /incds=0 /nref=193 /ntot=249 /MaxReadThrough="5.33526" /MaxDrop="6.88149" /score="18.2078317" /energy="-8.7" /TU="U1713" /idTUdmin="U1714" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" misc_feature complement(2000086..2000105) /Source="Nicolas_upshift_promotors" /id="U1713" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.618381618381618" /psig="0.97002997002997" /xcortree=1972 /SigmaFactorBS="ccgggattgatgccgaaacgtcgtaatagaaggcttggagcg acTATGATAGAATAAGTCACAGatatgctataggaggacgatcatgaagataaaatca a" /listShort="ypgR, S823, ilvD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2000089) /Source="Nicolas_upshifts" /id="U1713" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.618381618381618" /psig="0.97002997002997" /xcortree=1972 /SigmaFactorBS="ccgggattgatgccgaaacgtcgtaatagaaggcttggagcg acTATGATAGAATAAGTCACAGatatgctataggaggacgatcatgaagataaaatca a" /listShort="ypgR, S823, ilvD" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2000124..2000741) /gene="hdhQ" /locus_tag="BSU_21890" /old_locus_tag="BSU21890" /EC_number="3.6.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:25005104, 27062940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25005104, 27062940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="Mn(2+)-dependent (deoxy)ribonucleoside pyrophosphohydrolase" /protein_id="NP_390072.1" /db_xref="EnsemblGenomes-Gn:BSU21890" /db_xref="EnsemblGenomes-Tr:CAB14107" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR006674" /db_xref="SubtiList:BG11612" /db_xref="UniProtKB/Swiss-Prot:P54168" /translation="MKELKQAEQIRTWVQSILTDESSGHDWHHVSRVADLAAYIGEKE KADLFIVETAALVHDLIDVKLPDTVRLSVSEVYDQLVFFGVGKENADRVIHIITRMSF RDRGKLAKEPLSIEGKAVQDADRLDAIGAVGIARAFMFAGAKGHGLYGDEQSAYAHFF HKLLRLKDMMNTDTARELAEERHNFMLQFVRQLEKDIPGIDAETS*" /label="hdhQ CDS" gene complement(2000124..2000741) /gene="hdhQ" /locus_tag="BSU_21890" /old_locus_tag="BSU21890" /label="hdhQ gene" CDS complement(2000757..2001239) /gene="bsaA" /locus_tag="BSU_21900" /old_locus_tag="BSU21900" /EC_number="1.11.1.-" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 14563871, 14617062, 21749987, 25852656; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bacillithiol peroxidase" /protein_id="NP_390073.1" /db_xref="EnsemblGenomes-Gn:BSU21900" /db_xref="EnsemblGenomes-Tr:CAB14108" /db_xref="GOA:P52035" /db_xref="InterPro:IPR000889" /db_xref="InterPro:IPR029759" /db_xref="InterPro:IPR029760" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG11530" /db_xref="UniProtKB/Swiss-Prot:P52035" /translation="MSIYHMKVRTITGKDMTLQPFAGKVLMIVNTASKCGFTSQLKQL QELYDTYQQEGLEILGFPCNQFMNQEPGEEADIQEFCETNYGVTFPMFSKVDVNGKNA HPLFVYLTEHAKGMLGTKAIKWNFTKFIVDRNGEIVGRYSPNTNPKELEDDIVKLLEQ *" /label="bsaA CDS" gene complement(2000757..2001239) /gene="bsaA" /locus_tag="BSU_21900" /old_locus_tag="BSU21900" /label="bsaA gene" S_feature complement(2001240..2001387) /Source="Nicolas_S_feature" /locus_tag="new_2305036_2305183_c" /HighExp="S2, HiOs, S1, Etha, T2.30H, T3.0H, Lbtran, M0t90, T2.0H, SMMPr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S824" promotor_-10 complement(2001378..2001396) /Source="Nicolas_upshift_promotors" /id="U1714" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=3200 /SigmaFactorBS="tggtttcacagtaaaatgattttcaaagatgtaAGAGGGAAT tgtaatgtttTATAGAATGATAAGATAAAaaacgagccatatgaattgataatgaact g" /listShort="S824, bsaA, ypgQ, ypgR" /listLong="S823, ilvD" /label="promotor_-10" upshifts complement(2001388) /Source="Nicolas_upshifts" /id="U1714" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=3200 /SigmaFactorBS="tggtttcacagtaaaatgattttcaaagatgtaAGAGGGAAT tgtaatgtttTATAGAATGATAAGATAAAaaacgagccatatgaattgataatgaact g" /listShort="S824, bsaA, ypgQ, ypgR" /listLong="S823, ilvD" /label="upshifts" promotor_-35 complement(2001407..2001415) /Source="Nicolas_upshift_promotors" /id="U1714" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=3200 /SigmaFactorBS="tggtttcacagtaaaatgattttcaaagatgtaAGAGGGAAT tgtaatgtttTATAGAATGATAAGATAAAaaacgagccatatgaattgataatgaact g" /listShort="S824, bsaA, ypgQ, ypgR" /listLong="S823, ilvD" /label="promotor_-35" promotor_-35 2001441..2001450 /Source="Nicolas_upshift_promotors" /id="U1715" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1652 /SigmaFactorBS="caattccctcttacatctttgaaaatcattttactgTGAAAC CAAAaggcgtgtcagtGCGTTTTATTTAAAGAgttttctgttgtttccccctcaacac g" /listShort="S825, metA, S826, ugtP" /listLong="S828, cspD, S829, ypzA" /label="promotor_-35" promotor_-10 2001463..2001478 /Source="Nicolas_upshift_promotors" /id="U1715" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1652 /SigmaFactorBS="caattccctcttacatctttgaaaatcattttactgTGAAAC CAAAaggcgtgtcagtGCGTTTTATTTAAAGAgttttctgttgtttccccctcaacac g" /listShort="S825, metA, S826, ugtP" /listLong="S828, cspD, S829, ypzA" /label="promotor_-10" S_feature 2001465..2001551 /Source="Nicolas_S_feature" /locus_tag="new_2305261_2305347" /HighExp="Salt, T-0.40H, T-1.10H, Heat, T-1.40H, H2O2, T0.0H, Paraq, T0.30H, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S825" upshifts 2001465 /Source="Nicolas_upshifts" /id="U1715" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1652 /SigmaFactorBS="caattccctcttacatctttgaaaatcattttactgTGAAAC CAAAaggcgtgtcagtGCGTTTTATTTAAAGAgttttctgttgtttccccctcaacac g" /listShort="S825, metA, S826, ugtP" /listLong="S828, cspD, S829, ypzA" /label="upshifts" promotor_-35 2001514..2001521 /Source="Nicolas_upshift_promotors" /id="U1716" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.612387612387612" /psig="0.995004995004995" /xcortree=2257 /SigmaFactorBS="ccccctcaacacgtatagataGATTGAAAattggcgtgaaaa tTCCTATAATGAAGAAAATTAaacggggaaataatggaggtggcacgttgcctattaa t" /listShort="metA, S826, ugtP" /listLong="S828, cspD, S829, ypzA" /label="promotor_-35" promotor_-10 2001536..2001555 /Source="Nicolas_upshift_promotors" /id="U1716" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.612387612387612" /psig="0.995004995004995" /xcortree=2257 /SigmaFactorBS="ccccctcaacacgtatagataGATTGAAAattggcgtgaaaa tTCCTATAATGAAGAAAATTAaacggggaaataatggaggtggcacgttgcctattaa t" /listShort="metA, S826, ugtP" /listLong="S828, cspD, S829, ypzA" /label="promotor_-10" upshifts 2001553 /Source="Nicolas_upshifts" /id="U1716" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.612387612387612" /psig="0.995004995004995" /xcortree=2257 /SigmaFactorBS="ccccctcaacacgtatagataGATTGAAAattggcgtgaaaa tTCCTATAATGAAGAAAATTAaacggggaaataatggaggtggcacgttgcctattaa t" /listShort="metA, S826, ugtP" /listLong="S828, cspD, S829, ypzA" /label="upshifts" CDS 2001582..2002487 /gene="metAA" /locus_tag="BSU_21910" /old_locus_tag="BSU21910" /EC_number="2.3.1.31" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:5001847, 10939241, 11832514, 17056751, 18216013, 28581482" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 5001847, 10939241, 11832514, 17056751, 18216013, 28581482; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="homoserine O-acetyltransferase" /protein_id="NP_390074.2" /db_xref="EnsemblGenomes-Gn:BSU21910" /db_xref="EnsemblGenomes-Tr:CAB14109" /db_xref="GOA:P54167" /db_xref="InterPro:IPR005697" /db_xref="InterPro:IPR029062" /db_xref="InterPro:IPR033752" /db_xref="SubtiList:BG11534" /db_xref="UniProtKB/Swiss-Prot:P54167" /translation="MPINIPTHLPAKQVLESEHIFVMDESRAFHQDIRPQKIIILNLM PKKIQTETQLLRLLGNSPLQVHFTFLIPSTHTPKNTAREHLDEFYTTFSNIRHKRFDG MIITGAPIEHLAFEEVSYWEELKEIMEWSKTNVTSTLHICWGAQAGLYYHYGVEKIQM PKKIFGVFEHTVLSKHERLVRGFDELYYVPHSRHTDINMEQLQAVPELNILTASKEAG VCLIVSKDEKQVFLTGHPEYDTNTLLQEYERDLERNLSTVEAPKHYFAKGSNEPVNRW KAHATLLFMNWLNYYVYQETPYEWD*" /label="metAA CDS" gene 2001582..2002487 /gene="metAA" /locus_tag="BSU_21910" /old_locus_tag="BSU21910" /label="metAA gene" misc_feature 2002522..2002541 /Source="Nicolas_upshift_promotors" /id="U1717" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.982017982017982" /psig="0.999000999001" /xcortree=2287 /SigmaFactorBS="gaatgggactaatttttctttttttagtgatacgctgagcaa aaaaTATGATAAAATACATCTGATtcagtctgcgtataacaaaaatttaaaatactgg a" /listShort="S826, ugtP" /listLong="S828, cspD, S829, ypzA" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2002536 /Source="Nicolas_upshifts" /id="U1717" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.982017982017982" /psig="0.999000999001" /xcortree=2287 /SigmaFactorBS="gaatgggactaatttttctttttttagtgatacgctgagcaa aaaaTATGATAAAATACATCTGATtcagtctgcgtataacaaaaatttaaaatactgg a" /listShort="S826, ugtP" /listLong="S828, cspD, S829, ypzA" /label="upshifts" S_feature 2002537..2002717 /Source="Nicolas_S_feature" /locus_tag="new_2306333_2306513" /HighExp="Heat, HiTm, LoTm, C90, M9-stat, HiOs, SMM, UNK1, MG 25, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigWXY" /TUshortPSig="0.999, 0.995, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S826" CDS 2002718..2003866 /gene="ugtP" /locus_tag="BSU_21920" /old_locus_tag="BSU21920" /EC_number="2.4.1.315" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11344159, 17209021, 17662947, 9720862, 18820022, 22362028, 22931116, 27684739" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344159, 17209021, 17662947, 9720862, 18820022, 22362028, 22931116, 27684739; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-glucose diacylglyceroltransferase" /protein_id="NP_390075.1" /db_xref="EnsemblGenomes-Gn:BSU21920" /db_xref="EnsemblGenomes-Tr:CAB14110" /db_xref="GOA:P54166" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR009695" /db_xref="InterPro:IPR023589" /db_xref="SubtiList:BG11611" /db_xref="UniProtKB/Swiss-Prot:P54166" /translation="MNTNKRVLILTANYGNGHVQVAKTLYEQCVRLGFQHVTVSNLYQ ESNPIVSEVTQYLYLKSFSIGKQFYRLFYYGVDKIYNKRKFNIYFKMGNKRLGELVDE HQPDIIINTFPMIVVPEYRRRTGRVIPTFNVMTDFCLHKIWVHENVDKYYVATDYVKE KLLEIGTHPSNVKITGIPIRPQFEESMPVGPIYKKYNLSPNKKVLLIMAGAHGVLKNV KELCENLVKDDQVQVVVVCGKNTALKESLSALEAENGDKLKVLGYVERIDELFRITDC MITKPGGITLTEATAIGVPVILYKPVPGQEKENANFFEDRGAAIVVNRHEEILESVTS LLADEDTLHRMKKNIKDLHLANSSEVILEDILKESEMMTAKQKAKVLS*" /label="ugtP CDS" gene 2002718..2003866 /gene="ugtP" /locus_tag="BSU_21920" /old_locus_tag="BSU21920" /label="ugtP gene" S_feature complement(2002887..2003916) /Source="Nicolas_S_feature" /locus_tag="new_2306683_2307712_c" /HighExp="S8, S7, S6, C30, Lbstat, T0.30H, C90, BT, G135, Fru" /AntisenseName="ugtP" /AntisenseCor="-0.328222465122327" /AntisenseRegPval="-7.4" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S827" downshifts 2003862 /Source="Nicolas_upshifts" /id="D1146" /incds=0 /nref=77 /ntot=240 /MaxReadThrough="4.0787" /MaxDrop="4.20549" /score="21.6989702" /energy="-12.1" /TU="U1715,U1717" /idTUdmin="U1716" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2003898..2003917) /Source="Nicolas_upshift_promotors" /id="U1718" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1392 /SigmaFactorBS="cttatttttcaaaagaagggcaagttccataaaaaaATGTAA CCGcttttattgatggcTGAATATAAATAAAAAGAGCacacgattttcgtatgctctc a" /listShort="S827" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2003916) /Source="Nicolas_upshifts" /id="U1718" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1392 /SigmaFactorBS="cttatttttcaaaagaagggcaagttccataaaaaaATGTAA CCGcttttattgatggcTGAATATAAATAAAAAGAGCacacgattttcgtatgctctc a" /listShort="S827" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2003932..2003940) /Source="Nicolas_upshift_promotors" /id="U1718" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1392 /SigmaFactorBS="cttatttttcaaaagaagggcaagttccataaaaaaATGTAA CCGcttttattgatggcTGAATATAAATAAAAAGAGCacacgattttcgtatgctctc a" /listShort="S827" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2003947..2004093 /locus_tag="BSU_21925" /old_locus_tag="BSU21925" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513973.1" /translation="MELALLLKNKPFRNLTGAPRWCIVEPSFNNESKLDDDKIFFSTW VLQY*" /label="hypothetical protein CDS" gene 2003947..2004093 /locus_tag="BSU_21925" /old_locus_tag="BSU21925" /label="gene" promotor_-35 2003986..2003993 /Source="Nicolas_upshift_promotors" /id="U1719" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.829170829170829" /psig="0.999000999001" /xcortree=3102 /SigmaFactorBS="ccttcttttgaaaaataagccgtttcgcAACTTGACgggtgc tcccagaTGGTGTATAGTTGAACCATCatttaacaatgaatcaaagttagatgatgac a" /listShort="S828, cspD, S829, ypzA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2004007..2004026 /Source="Nicolas_upshift_promotors" /id="U1719" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.829170829170829" /psig="0.999000999001" /xcortree=3102 /SigmaFactorBS="ccttcttttgaaaaataagccgtttcgcAACTTGACgggtgc tcccagaTGGTGTATAGTTGAACCATCatttaacaatgaatcaaagttagatgatgac a" /listShort="S828, cspD, S829, ypzA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2004018..2004108 /Source="Nicolas_S_feature" /locus_tag="new_2307814_2307904" /HighExp="C90, T5.0H, T3.30H, T3.0H, HiOs, Salt, LoTm, T-3.40H, S3, T-0.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigA, SigA, SigWXY" /TUlongPSig="0.999, 0.995, 1" /label="S828" upshifts 2004018 /Source="Nicolas_upshifts" /id="U1719" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.829170829170829" /psig="0.999000999001" /xcortree=3102 /SigmaFactorBS="ccttcttttgaaaaataagccgtttcgcAACTTGACgggtgc tcccagaTGGTGTATAGTTGAACCATCatttaacaatgaatcaaagttagatgatgac a" /listShort="S828, cspD, S829, ypzA" /GFF_Attribute="listLong" /label="upshifts" CDS 2004109..2004309 /gene="cspD" /locus_tag="BSU_21930" /old_locus_tag="BSU21930" /function="16.13: Shape" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9920884, 16352840" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9920884, 16352840; Product type f: factor" /codon_start=1 /transl_table=11 /product="cold-shock protein, molecular chaperone, RNA-helicase co-factor" /protein_id="NP_390076.1" /db_xref="EnsemblGenomes-Gn:BSU21930" /db_xref="EnsemblGenomes-Tr:CAB14111" /db_xref="GOA:P51777" /db_xref="InterPro:IPR002059" /db_xref="InterPro:IPR011129" /db_xref="InterPro:IPR012156" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR019844" /db_xref="SubtiList:BG11531" /db_xref="UniProtKB/Swiss-Prot:P51777" /translation="MQNGKVKWFNNEKGFGFIEVEGGDDVFVHFTAIEGDGYKSLEEG QEVSFEIVEGNRGPQASNVVKL*" /label="cspD CDS" gene 2004109..2004309 /gene="cspD" /locus_tag="BSU_21930" /old_locus_tag="BSU21930" /label="cspD gene" downshifts 2004324 /Source="Nicolas_upshifts" /id="D1147" /incds=0 /nref=257 /ntot=269 /MaxReadThrough="5.19931" /MaxDrop="8.09346" /score="9.24662311" /energy="-15.6" /TU="U1719" /idTUdmin="U1715" /TUdmin=308 /isTUend="FALSE" /label="downshifts" CDS complement(2004361..2004543) /gene="degR" /locus_tag="BSU_21940" /old_locus_tag="BSU21940" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16625836, 19251843, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16625836, 19251843, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="activator of degradative enzymes (aprE, nprE, sacB) production or activity" /protein_id="NP_390077.1" /db_xref="EnsemblGenomes-Gn:BSU21940" /db_xref="EnsemblGenomes-Tr:CAB14112" /db_xref="GOA:P68731" /db_xref="SubtiList:BG10699" /db_xref="UniProtKB/Swiss-Prot:P68731" /translation="MDDKDLKLILHKTFIEIYSDLEELADIAKKGKPSMEKYVEEIEQ RCKQNILAIEIQMKIK*" /label="degR CDS" gene complement(2004361..2004543) /gene="degR" /locus_tag="BSU_21940" /old_locus_tag="BSU21940" /label="degR gene" S_feature 2004369..2004674 /Source="Nicolas_S_feature" /locus_tag="new_2308165_2308470" /HighExp="Cold, LoTm, T4.0H, T3.30H, Pyr, T5.0H, Gly, T3.0H, S0, C30" /AntisenseName="degR" /AntisenseCor="-0.145220711637392" /AntisenseRegPval="-1.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigA, SigA, SigWXY" /TUlongPSig="0.999, 0.995, 1" /label="S829" downshifts complement(2004378) /Source="Nicolas_upshifts" /id="D1148" /incds=0 /nref=133 /ntot=216 /MaxReadThrough="3.75638" /MaxDrop="5.32427" /score="16.1392275" /energy="-7.3" /TU="U1720" /idTUdmin="U1720" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2004604..2004622) /Source="Nicolas_upshift_promotors" /id="U1720" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=2841 /SigmaFactorBS="acaaaaaacacctccgccattattttgcagagtttttttgaa atttatgtaccaaaatAGAAAAGaaaataaaaataaGCCGATATAACTATTGAACcag a" /listShort="degR" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2004636..2004642) /Source="Nicolas_upshift_promotors" /id="U1720" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=2841 /SigmaFactorBS="acaaaaaacacctccgccattattttgcagagtttttttgaa atttatgtaccaaaatAGAAAAGaaaataaaaataaGCCGATATAACTATTGAACcag a" /listShort="degR" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2004640) /Source="Nicolas_upshifts" /id="U1720" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=2841 /SigmaFactorBS="acaaaaaacacctccgccattattttgcagagtttttttgaa atttatgtaccaaaatAGAAAAGaaaataaaaataaGCCGATATAACTATTGAACcag a" /listShort="degR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2004650..2004656 /Source="Nicolas_upshift_promotors" /id="U1721" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=913 /SigmaFactorBS="tatcggcttatttttattttcttttctattttggTACATAAa tttcaaaaaaactCTGCAAAATAATggcggaggtgttttttgtgacttcagaatttca t" /listShort="ypzA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2004671..2004682 /Source="Nicolas_upshift_promotors" /id="U1721" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=913 /SigmaFactorBS="tatcggcttatttttattttcttttctattttggTACATAAa tttcaaaaaaactCTGCAAAATAATggcggaggtgttttttgtgacttcagaatttca t" /listShort="ypzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2004676 /Source="Nicolas_upshifts" /id="U1721" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=913 /SigmaFactorBS="tatcggcttatttttattttcttttctattttggTACATAAa tttcaaaaaaactCTGCAAAATAATggcggaggtgttttttgtgacttcagaatttca t" /listShort="ypzA" /GFF_Attribute="listLong" /label="upshifts" CDS 2004699..2004968 /gene="ypzA" /locus_tag="BSU_21950" /old_locus_tag="BSU21950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12562816, 22882546; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="NP_390078.1" /db_xref="EnsemblGenomes-Gn:BSU21950" /db_xref="EnsemblGenomes-Tr:CAB14113" /db_xref="InterPro:IPR020314" /db_xref="SubtiList:BG13764" /db_xref="UniProtKB/Swiss-Prot:O32007" /translation="MTSEFHNEDQTGFTDKRQLELAVETAQKTTGAATRGQSKTLVDS AYQAIEDARELSQSEELAALDDPEFVKQQQQLLDDSEHQLDEFKE*" /label="ypzA CDS" gene 2004699..2004968 /gene="ypzA" /locus_tag="BSU_21950" /old_locus_tag="BSU21950" /label="ypzA gene" downshifts 2004823 /Source="Nicolas_upshifts" /id="D1149" /incds=1 /nref=3 /ntot=82 /MaxReadThrough="6.79633" /MaxDrop="4.11501" /score="22.0113838" /energy="-7.3" /TU="U1719,U1721" /idTUdmin="U1719" /TUdmin="-117" /isTUend="FALSE" /label="downshifts" downshifts 2004951 /Source="Nicolas_upshifts" /id="D1150" /incds=0 /nref=18 /ntot=94 /MaxReadThrough="2.31821" /MaxDrop="6.65627" /score="22.0113838" /energy="-7.3" /TU="NA" /idTUdmin="U1719" /TUdmin=11 /isTUend="TRUE" /label="downshifts" CDS complement(2004996..2005178) /gene="ypeQ" /locus_tag="BSU_21960" /old_locus_tag="BSU21960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12562816" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390079.1" /db_xref="EnsemblGenomes-Gn:BSU21960" /db_xref="EnsemblGenomes-Tr:CAB14114" /db_xref="InterPro:IPR019718" /db_xref="SubtiList:BG11610" /db_xref="UniProtKB/Swiss-Prot:P54165" /translation="MDKKMIFKELTELHDEYCKDCFIKKQFRKEFGKTYAHSFCINKC TVGEKLKQYGDVLTNH*" /label="ypeQ CDS" gene complement(2004996..2005178) /gene="ypeQ" /locus_tag="BSU_21960" /old_locus_tag="BSU21960" /label="ypeQ gene" downshifts complement(2005016) /Source="Nicolas_upshifts" /id="D1151" /incds=0 /nref=5 /ntot=102 /MaxReadThrough="2.77117" /MaxDrop="4.29218" /score="16.1392275" /energy="-7.3" /TU="NA" /idTUdmin="U1723" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2005171..2005851) /gene="ypeP" /locus_tag="BSU_21970" /old_locus_tag="BSU21970" /EC_number="3.1.-.-" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12562816, 17905985, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12562816, 17905985, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease" /protein_id="NP_390080.2" /db_xref="EnsemblGenomes-Gn:BSU21970" /db_xref="EnsemblGenomes-Tr:CAB14115" /db_xref="GOA:P54164" /db_xref="InterPro:IPR002156" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG11609" /db_xref="UniProtKB/Swiss-Prot:P54164" /translation="MKLRPHLKIEAKGTGSVSFFSEDWLTAQQARTFARELGRFPYMK ELEFEDEKGGSWTLKELEKLTEELAQEPDDITVYFDGSFDKESELAGLGIVIYYSLGG TRHRLRKNKSFRLKTNNEAEYAALYEAIREVRELGASRNSITIKGDSLVVLNQLDGSW PCYDPSHNEWLDKIEALLESLKLTPTYETIQRKDNQEADGLAKKILSHQFVESHTKLD RNGDDDIG*" /label="ypeP CDS" gene complement(2005171..2005851) /gene="ypeP" /locus_tag="BSU_21970" /old_locus_tag="BSU21970" /label="ypeP gene" S_feature complement(2005852..2005989) /Source="Nicolas_S_feature" /locus_tag="new_2309648_2309785_c" /HighExp="S5, S4, S6, S8, S7, S3, T5.0H, T4.0H, BT, Pyr" /AntisenseName="ypdP" /AntisenseCor="-0.65324924042743404" /AntisenseRegPval="-33.4" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH" /TUshortPSig="0.92, 0.564" /TUlongSig="NA" /TUlongPSig="NA" /label="S830" promotor_-35 2005868..2005873 /Source="Nicolas_upshift_promotors" /id="U1722" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.985014985014985" /psig="0.999000999001" /xcortree=2280 /SigmaFactorBS="caaatgcggtctgagcttcattacaatcaccttaccaTTCAT TagttgccgggctTATGCTATAATCAAACCAATcttaccccggaaaggaagctttttc a" /listShort="ypdP, ypdQ, sspL, S832" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2005886..2005905 /Source="Nicolas_upshift_promotors" /id="U1722" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.985014985014985" /psig="0.999000999001" /xcortree=2280 /SigmaFactorBS="caaatgcggtctgagcttcattacaatcaccttaccaTTCAT TagttgccgggctTATGCTATAATCAAACCAATcttaccccggaaaggaagctttttc a" /listShort="ypdP, ypdQ, sspL, S832" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2005891 /Source="Nicolas_upshifts" /id="U1722" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.985014985014985" /psig="0.999000999001" /xcortree=2280 /SigmaFactorBS="caaatgcggtctgagcttcattacaatcaccttaccaTTCAT TagttgccgggctTATGCTATAATCAAACCAATcttaccccggaaaggaagctttttc a" /listShort="ypdP, ypdQ, sspL, S832" /GFF_Attribute="listLong" /label="upshifts" CDS 2005934..2006623 /gene="queP" /locus_tag="BSU_21980" /old_locus_tag="BSU21980" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 28208705; Product type t : transporter" /codon_start=1 /transl_table=11 /product="preQ0 transporter (promiscuous)" /protein_id="NP_390081.1" /db_xref="EnsemblGenomes-Gn:BSU21980" /db_xref="EnsemblGenomes-Tr:CAB14116" /db_xref="GOA:P54163" /db_xref="InterPro:IPR003744" /db_xref="SubtiList:BG11607" /db_xref="UniProtKB/Swiss-Prot:P54163" /translation="MFNNSFWIFFAIIHFIIVLLFYKGFGKMGLFVWIGFATVCANLQ VVKTVELFGLTATLGNVMYGTIFFATDVLNEKYGPAEARKAVWLGFSTLLTLTFVMQG VLLFEPASSDISQTALETIFGFLPRVALGSLLAFIFSQTLDVYVYSAIRRIFPSDRLL WLRNGGSTAVSQLFDTFIFTAVAFLGIYPADVWLHIFISTYLIKFAVSLISLPYAYAA KKMIPNDERSS*" /label="queP CDS" gene 2005934..2006623 /gene="queP" /locus_tag="BSU_21980" /old_locus_tag="BSU21980" /label="queP gene" promotor_-35 complement(2005987..2006003) /Source="Nicolas_upshift_promotors" /id="U1723" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.417582417582418" /psig="0.92007992007992" /xcortree=644 /SigmaFactorBS="gactgtcgcaaaaccgatccaaacaaacagtcccattttgcc aaatcCTTTATAAAATAAAAGAacAatgataaaatgaatgatcgcaaaaaagatccaa a" /listShort="S830, ypeP, ypeQ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2005990) /Source="Nicolas_upshifts" /id="U1723" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.417582417582418" /psig="0.92007992007992" /xcortree=644 /SigmaFactorBS="gactgtcgcaaaaccgatccaaacaaacagtcccattttgcc aaatcCTTTATAAAATAAAAGAacAatgataaaatgaatgatcgcaaaaaagatccaa a" /listShort="S830, ypeP, ypeQ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2005991..2006380) /Source="Nicolas_S_feature" /locus_tag="new_2309787_2310176_c" /HighExp="S5, S4, S6, S7, S8, T5.0H, S3, T4.0H, BT, M9-stat" /AntisenseName="ypdP" /AntisenseCor="-0.645700204826543" /AntisenseRegPval="-32.4" /CDS_PredictionProba="NA" /TUshortSig="SigH" /TUshortPSig="0.564" /TUlongSig="NA" /TUlongPSig="NA" /label="S831" promotor_-10 complement(2006361..2006380) /Source="Nicolas_upshift_promotors" /id="U1724" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.564435564435564" /psig="0.564435564435564" /xcortree=1217 /SigmaFactorBS="ctgtactgccgccgtttctgagccataaaagccgatcaGAAG GAAATatccttctaatTGCCGAATATACATAAACATccagcgtttggctgaagataaa g" /listShort="S831, S830, ypeP, ypeQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2006378) /Source="Nicolas_upshifts" /id="U1724" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.564435564435564" /psig="0.564435564435564" /xcortree=1217 /SigmaFactorBS="ctgtactgccgccgtttctgagccataaaagccgatcaGAAG GAAATatccttctaatTGCCGAATATACATAAACATccagcgtttggctgaagataaa g" /listShort="S831, S830, ypeP, ypeQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2006392..2006400) /Source="Nicolas_upshift_promotors" /id="U1724" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.564435564435564" /psig="0.564435564435564" /xcortree=1217 /SigmaFactorBS="ctgtactgccgccgtttctgagccataaaagccgatcaGAAG GAAATatccttctaatTGCCGAATATACATAAACATccagcgtttggctgaagataaa g" /listShort="S831, S830, ypeP, ypeQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2006623..2007021 /gene="ypdQ" /locus_tag="BSU_21990" /old_locus_tag="BSU21990" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9888800, 10094689, 15115438, 17905985; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative RNA binding protein (no RNase H activity)" /protein_id="NP_390082.1" /db_xref="EnsemblGenomes-Gn:BSU21990" /db_xref="EnsemblGenomes-Tr:CAB14117" /db_xref="GOA:P54162" /db_xref="InterPro:IPR002156" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG11608" /db_xref="UniProtKB/Swiss-Prot:P54162" /translation="MPTEIYVDGASAGNPGPSGIGIFIKHEGKAESFSIPIGVHTNQE AEFLALIEGMKLCATRGYQSVSFRTDSDIVERATELEMVKNITFQPFVEEIIRLKAAF PLFFIKWIPGKQNQKADLLAKEAIRLNEKN*" /label="ypdQ CDS" gene 2006623..2007021 /gene="ypdQ" /locus_tag="BSU_21990" /old_locus_tag="BSU21990" /label="ypdQ gene" promotor_-35 2007014..2007020 /Source="Nicolas_upshift_promotors" /id="U1725" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=921 /SigmaFactorBS="gcaaaagaagcgattcggctgaatgaaaAGAATTAaatcttg atcattgGTTCATCCTAATggcgaggtgaactaacatgaaaaagaaagataaaggccg g" /listShort="sspL, S832" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2007035..2007046 /Source="Nicolas_upshift_promotors" /id="U1725" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=921 /SigmaFactorBS="gcaaaagaagcgattcggctgaatgaaaAGAATTAaatcttg atcattgGTTCATCCTAATggcgaggtgaactaacatgaaaaagaaagataaaggccg g" /listShort="sspL, S832" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2007046 /Source="Nicolas_upshifts" /id="U1725" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=921 /SigmaFactorBS="gcaaaagaagcgattcggctgaatgaaaAGAATTAaatcttg atcattgGTTCATCCTAATggcgaggtgaactaacatgaaaaagaaagataaaggccg g" /listShort="sspL, S832" /GFF_Attribute="listLong" /label="upshifts" CDS 2007063..2007191 /gene="sspL" /locus_tag="BSU_22000" /old_locus_tag="BSU22000" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10333516" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10333516; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="YP_054584.1" /db_xref="EnsemblGenomes-Gn:BSU22000" /db_xref="EnsemblGenomes-Tr:CAE01458" /db_xref="GOA:Q7WY66" /db_xref="InterPro:IPR017526" /db_xref="SubtiList:BG14176" /db_xref="UniProtKB/Swiss-Prot:Q7WY66" /translation="MKKKDKGRLTGGVTPQGDLEGNTHNDPKTELEERAKKSNTKR*" /label="sspL CDS" gene 2007063..2007191 /gene="sspL" /locus_tag="BSU_22000" /old_locus_tag="BSU22000" /label="sspL gene" S_feature 2007192..2008172 /Source="Nicolas_S_feature" /locus_tag="new_2310988_2311968" /HighExp="S8, S7, S5, S6, S4, C30, nit, ferm, Pyr, S3" /AntisenseName="exoA" /AntisenseCor="-0.365099613028674" /AntisenseRegPval="-9.1999999999999993" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigA" /TUshortPSig="0.999, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S832" CDS complement(2007199..2008089) /gene="exnP" /locus_tag="BSU_22010" /old_locus_tag="BSU22010" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:16045613, 17038322, 17905985, 27435445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16045613, 17038322, 17905985, 27435445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5'3'-exonuclease" /protein_id="NP_390083.1" /db_xref="EnsemblGenomes-Gn:BSU22010" /db_xref="EnsemblGenomes-Tr:CAB14118" /db_xref="GOA:P54161" /db_xref="InterPro:IPR002421" /db_xref="InterPro:IPR008918" /db_xref="InterPro:IPR020045" /db_xref="InterPro:IPR020046" /db_xref="InterPro:IPR029060" /db_xref="InterPro:IPR036279" /db_xref="SubtiList:BG11606" /db_xref="UniProtKB/Swiss-Prot:P54161" /translation="MNNNKLLLVDGMALLFRAFFATAVHRNFMINDSGVPTNGVNGFL KHLITAVETFQPTHVVCCWDMGSKTYRNDLFQDYKANRSAPPVELIPQFDLAKEAAAE LGIMNIGFAGYEADDCIGTLADLFANEADITVVTGDRDLLQLLTDKVSVALLQKGIGN YKVYTKETFYEETGVMPKALIDIKALMGDSSDNYPGVKGIGEKTAYKLIREYETIDRL LENLSLLPKGQQGKIQQGLSDLEMSRKLAEIHCSVPLACTLKDALFTLQMEQAADMLR RHQIKGIERMLEKLNAREIV*" /label="exnP CDS" gene complement(2007199..2008089) /gene="exnP" /locus_tag="BSU_22010" /old_locus_tag="BSU22010" /label="exnP gene" downshifts complement(2007236) /Source="Nicolas_upshifts" /id="D1152" /incds=0 /nref=10 /ntot=174 /MaxReadThrough="2.94148" /MaxDrop="4.49836" /score="3.60870815" /energy="-15.6" /TU="U1726" /idTUdmin="U1726" /TUdmin="-284" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2008111..2008130) /Source="Nicolas_upshift_promotors" /id="U1726" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2164 /SigmaFactorBS="acagtatctctaattaaagagatactgtttTTTATTTttggg ctgcttTATGATAAAATAGAAGGAATgaaagaaaagggagttatttgatgaataataa t" /listShort="exoA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2008118) /Source="Nicolas_upshifts" /id="U1726" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2164 /SigmaFactorBS="acagtatctctaattaaagagatactgtttTTTATTTttggg ctgcttTATGATAAAATAGAAGGAATgaaagaaaagggagttatttgatgaataataa t" /listShort="exoA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2008142..2008148) /Source="Nicolas_upshift_promotors" /id="U1726" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2164 /SigmaFactorBS="acagtatctctaattaaagagatactgtttTTTATTTttggg ctgcttTATGATAAAATAGAAGGAATgaaagaaaagggagttatttgatgaataataa t" /listShort="exoA" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2008146 /Source="Nicolas_upshifts" /id="D1153" /incds=0 /nref=4 /ntot=32 /MaxReadThrough="0.83304" /MaxDrop="4.41573" /score="0.126370352" /energy="-15" /TU="NA" /idTUdmin="U1725" /TUdmin=16 /isTUend="TRUE" /label="downshifts" CDS complement(2008190..2008336) /gene="ypzF" /locus_tag="BSU_22019" /old_locus_tag="BSU22019" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097753.1" /db_xref="EnsemblGenomes-Gn:BSU22019" /db_xref="EnsemblGenomes-Tr:CAX52652" /db_xref="UniProtKB/Swiss-Prot:C0H443" /translation="MLGRTKLGNRNAQANNNAKKKNGFQTHFDSYAGREAEKLIASNK RHND*" /label="ypzF CDS" gene complement(2008190..2008336) /gene="ypzF" /locus_tag="BSU_22019" /old_locus_tag="BSU22019" /label="ypzF gene" downshifts complement(2008206) /Source="Nicolas_upshifts" /id="D1154" /incds=0 /nref=253 /ntot=272 /MaxReadThrough="0.89691" /MaxDrop="8.47168" /score="25.632979" /energy="-12" /TU="NA" /idTUdmin="U1727" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts complement(2008360) /Source="Nicolas_upshifts" /id="U1727" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=846 /SigmaFactorBS="ccgcatgtaagctggatgatcctgtcgCGAGTGAacctcctg ccggaaGCATATACTATAtgcatccgacgtaaggggggattcatgttgggcagaacaa a" /listShort="ypzF" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2008361..2008372) /Source="Nicolas_upshift_promotors" /id="U1727" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=846 /SigmaFactorBS="ccgcatgtaagctggatgatcctgtcgCGAGTGAacctcctg ccggaaGCATATACTATAtgcatccgacgtaaggggggattcatgttgggcagaacaa a" /listShort="ypzF" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2008387..2008393) /Source="Nicolas_upshift_promotors" /id="U1727" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=846 /SigmaFactorBS="ccgcatgtaagctggatgatcctgtcgCGAGTGAacctcctg ccggaaGCATATACTATAtgcatccgacgtaaggggggattcatgttgggcagaacaa a" /listShort="ypzF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2008411..2008668) /gene="ypbS" /locus_tag="BSU_22020" /old_locus_tag="BSU22020" /experiment="publication(s) with functional evidences, PMID:20709900, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20709900, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="spore associated protein" /protein_id="NP_390084.1" /db_xref="EnsemblGenomes-Gn:BSU22020" /db_xref="EnsemblGenomes-Tr:CAB14119" /db_xref="InterPro:IPR019688" /db_xref="SubtiList:BG11605" /db_xref="UniProtKB/Swiss-Prot:P54160" /translation="MSEVHKAISAHSSKQHEHIKAFMRLENMRELAIEEAVAKCRNDE PYTTDAINEITEQMNQLAKKGIVPTRRLVSKEMVREYVSRM*" /label="ypbS CDS" gene complement(2008411..2008668) /gene="ypbS" /locus_tag="BSU_22020" /old_locus_tag="BSU22020" /label="ypbS gene" promotor_-10 complement(2008688..2008707) /Source="Nicolas_upshift_promotors" /id="U1728" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.678321678321678" /psig=1 /xcortree=3060 /SigmaFactorBS="gaaaaattcagacaatacaataaaaatgtaaaattcaGTTGG CTTgtatttcaagtCATGATAGACTAAATAGAAAaaagcgagatgaacgattaatgtc a" /listShort="ypbS, ypzF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2008703) /Source="Nicolas_upshifts" /id="U1728" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.678321678321678" /psig=1 /xcortree=3060 /SigmaFactorBS="gaaaaattcagacaatacaataaaaatgtaaaattcaGTTGG CTTgtatttcaagtCATGATAGACTAAATAGAAAaaagcgagatgaacgattaatgtc a" /listShort="ypbS, ypzF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2008719..2008726) /Source="Nicolas_upshift_promotors" /id="U1728" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.678321678321678" /psig=1 /xcortree=3060 /SigmaFactorBS="gaaaaattcagacaatacaataaaaatgtaaaattcaGTTGG CTTgtatttcaagtCATGATAGACTAAATAGAAAaaagcgagatgaacgattaatgtc a" /listShort="ypbS, ypzF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2008733..2012314) /gene="dynA" /locus_tag="BSU_22030" /old_locus_tag="BSU22030" /EC_number="3.6.5.5" /experiment="publication(s) with functional evidences, PMID:21205012, 23388828, 23249255, 26842743, 26530236" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21205012, 23388828, 23249255, 26842743, 26530236; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dynamin GTPase" /protein_id="NP_390085.1" /db_xref="EnsemblGenomes-Gn:BSU22030" /db_xref="EnsemblGenomes-Tr:CAB14120" /db_xref="GOA:P54159" /db_xref="InterPro:IPR022812" /db_xref="InterPro:IPR027094" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11604" /db_xref="UniProtKB/Swiss-Prot:P54159" /translation="MTDQNRKELLHKTGELYKQFIENQDEQRAAKLAAVMKKAADEEV YIAFTGHYSAGKSSLLNCLLMENILPTSPIPTSANLVVIRNGEKRVRLHTTDGACAEL EGTYQKDKVQQYCKDGEQIESVEIFDRYTEIDSGVAYIDTPGIDSTDDAHFLSAASIL HQADALFYVVHYNHVHAEENVKFLRSIKESIPNVYFIVNQIDRHDETETKFGDYQAQV EEMLCNEGISREALYFTSVTEPDHPFNQMGALREELSRIEQQSKSNMQALTEQKVRNL LKEHTEMLKKDETGAPSFAEQLNIHTGLVQSLRDQLDEAEKQMTEAEKRMQEEINRIL KNANLTPFEMRELAAAFLESQEPSFKTGFFFSKAKTAQERDKRRNAFFSDVAKRTEAE ADWHMIDTLHKLAKVFDVYTAESEKLIQAYRTPLDISIIEHAVKHGAAFSSEYVLQYT KDLAELIRKEAKREAADIIKVLSAMVKERVSKDVQTINDRLVQESEKLVFLQEQARLE NNAREKTDRLWAIWEEESACPMHIDTEWFKSKKTRVAAPEQKQGRSQLTAQPMPKSEI KMEQEMPLQDQIKRFYTLSDILGECSMLLKQTSAFRERVKRLEERKFTLALFGGFSSG KSSFANALVGERVLPSSPTPTTATINKITKPINGNLNKTANVVFKTEDDLTAEILQLT GIPKEPAGRSFTEKWEKAVKKNRLQEEHVKLISNFLLAYEKYQQYIQEQKKLTIPLSE LKPYVAEETTACAVKEVTVYYTCPLTEKGITIVDTPGASSMNKRHTELAFQYIKDADA FFYMTYYQHSFSKGDRSFLRKLGLVKESLSMDKMFFIINAADLAKDKTELETVTDYVS AELVKEGVYEPQLFTVSSKEELVGKPESFYNQFSKVRKHLDRFIEVDVKKASAAQLSS EADKLCETVFQLHQSQHQSREEKEAQKQCLMLSFERTAADIEKRRNSKTIIEKVKKDT REQLYHIAQRLSYFANDLLKSAFHPGLQNGDWKKNVSKAMTTALHEYLFEYIQEIKTL DVRMSGFIERHINEEWLDHFQKTLNEDGYFSVYAGDQHSNGIQLKEVEPEIEERAFEQ ELKEIKSPKQFFEQKGKATFIEAVRMKLTKITEAWIKNEEESLISHYTAHLRRLQEDM GEKAIAQITDQKETYLRGYAEGEHAKEIEMAYQACISWKNSDNTIKM*" /label="dynA CDS" gene complement(2008733..2012314) /gene="dynA" /locus_tag="BSU_22030" /old_locus_tag="BSU22030" /label="dynA gene" S_feature complement(2012315..2012386) /Source="Nicolas_S_feature" /locus_tag="new_2316111_2316182_c" /HighExp="LBGstat, T1.30H, T1.0H, BMM, T2.30H, M9-stat, MG 150, T0.30H, T2.0H, GM-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S833" misc_feature complement(2012376..2012395) /Source="Nicolas_upshift_promotors" /id="U1729" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.61038961038961" /psig="0.987012987012987" /xcortree=2239 /SigmaFactorBS="gctgccgtaatggcggcttttttctattctcctaaagaaatt tggtttattCTTGTGTAAAATGAAAAGGGaatgaattcagatctttcgaaaaaggttc a" /listShort="S833, ypbR" /listLong="ypbS, ypzF" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2012386) /Source="Nicolas_upshifts" /id="U1729" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.61038961038961" /psig="0.987012987012987" /xcortree=2239 /SigmaFactorBS="gctgccgtaatggcggcttttttctattctcctaaagaaatt tggtttattCTTGTGTAAAATGAAAAGGGaatgaattcagatctttcgaaaaaggttc a" /listShort="S833, ypbR" /listLong="ypbS, ypzF" /label="upshifts" S_feature complement(2012431..2012628) /Source="Nicolas_S_feature" /locus_tag="new_2316227_2316424_c" /HighExp="HiOs, B60, GM 25, S7, GM 15, B36, S5, S8, GM 5, GM 60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.24118200000000001" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S834" downshifts complement(2012474) /Source="Nicolas_upshifts" /id="D1155" /incds=0 /nref=1 /ntot=38 /MaxReadThrough="3.11615" /MaxDrop="3.46525" /score="27.1937922" /energy="-9.7" /TU="U1730" /idTUdmin="U1730" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(2012490..2012579) /gene="fbpC" /locus_tag="BSU_22036" /old_locus_tag="BSU22036" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:18697947, 22389480, 22427629" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18697947, 22389480, 22427629; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of iron homeostasis" /protein_id="YP_009513974.1" /db_xref="EnsemblGenomes-Gn:BSU22036" /db_xref="EnsemblGenomes-Tr:CCQ48599" /db_xref="UniProtKB/TrEMBL:L8ECR0" /translation="MTMLFLLGAVCTYSVLIGFVLKGISNKSV*" /label="fbpC CDS" gene complement(2012490..2012579) /gene="fbpC" /locus_tag="BSU_22036" /old_locus_tag="BSU22036" /label="fbpC gene" promotor_-10 complement(2012607..2012626) /Source="Nicolas_upshift_promotors" /id="U1730" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=2098 /SigmaFactorBS="gcagaagacaaagcattacaggaatacagcgtaaaatagcGA TTGAAAatcattctcaaccaTGTTAAAATGGGTTTGAAAAagattctcaatcaggatg g" /listShort="S834" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2012628) /Source="Nicolas_upshifts" /id="U1730" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=2098 /SigmaFactorBS="gcagaagacaaagcattacaggaatacagcgtaaaatagcGA TTGAAAatcattctcaaccaTGTTAAAATGGGTTTGAAAAagattctcaatcaggatg g" /listShort="S834" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2012641..2012648) /Source="Nicolas_upshift_promotors" /id="U1730" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=2098 /SigmaFactorBS="gcagaagacaaagcattacaggaatacagcgtaaaatagcGA TTGAAAatcattctcaaccaTGTTAAAATGGGTTTGAAAAagattctcaatcaggatg g" /listShort="S834" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2012650..2013156) /gene="bpsB" /locus_tag="BSU_22040" /old_locus_tag="BSU22040" /EC_number="2.1.1.-" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12354229, 15849754, 16850406, 7726551, 8396117, 19465653" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15849754, 16850406, 7726551, 8396117, 19465653; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="alkylpyrone methyltransferase (polyketide synthesis)" /protein_id="NP_390086.1" /db_xref="EnsemblGenomes-Gn:BSU22040" /db_xref="EnsemblGenomes-Tr:CAB14121" /db_xref="GOA:P54158" /db_xref="InterPro:IPR007269" /db_xref="SubtiList:BG11603" /db_xref="UniProtKB/Swiss-Prot:P54158" /translation="MFWLLIAILIVQRAAEMAVARQNEQKVKKQGAIEFGESHYPYII TMHILFFLSLIAEVLLMNKQPSSWWLGIAAVILSVQIVRYWALCSLGAYWNTKILVVP GVELVKKGPYKWMKHPNYAVVILEILLIPLLYQAYVTMCLFSIFNAVLLSVRIRAEDK ALQEYSVK*" /label="bpsB CDS" gene complement(2012650..2013156) /gene="bpsB" /locus_tag="BSU_22040" /old_locus_tag="BSU22040" /label="bpsB gene" CDS complement(2013160..2014257) /gene="bpsA" /locus_tag="BSU_22050" /old_locus_tag="BSU22050" /EC_number="2.3.1.-" /function="15.10: Adaptations to atypical conditions" /experiment="publication(s) with functional evidences, PMID:19465653" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19465653; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous alkylpyrone synthase BpsA (polyketide synthesis)" /protein_id="NP_390087.1" /db_xref="EnsemblGenomes-Gn:BSU22050" /db_xref="EnsemblGenomes-Tr:CAB14122" /db_xref="GOA:P54157" /db_xref="InterPro:IPR001099" /db_xref="InterPro:IPR011141" /db_xref="InterPro:IPR012328" /db_xref="InterPro:IPR016039" /db_xref="InterPro:IPR018088" /db_xref="SubtiList:BG11523" /db_xref="UniProtKB/Swiss-Prot:P54157" /translation="MAFILSIGTSLPAYNVNQEKAAEFARYMFQHSFKDIDRLLSSFK NGQIHSRQFVKPIEWYKEGHSFEEKNQIYIEETLKHSRAAVRECLSHPEFFQEAIPYE KVEAVFFVSSTGLSTPSIEARLMNELPFSPYTKRIPIWGLGCAGGASGLARAAEYCKA YPEAFVLVISAELCSLTFQPEDKTKSNLIGTSLFGDGIAAALLCGEKADRRVSKLKLA PKIMDAQSVLMKQSEDVMGWDFTDQGFKVIFSRDIPTLVEKWLKTNVQIFLDKHKLSF HDISVFLAHPGGKKVIDAYIKSLGLSSEKLSSAQSILQKHGNMSSATILYVIKDHLQN GHKKEAERGLIGALGPGFSSELLLFSWEKGA*" /label="bpsA CDS" gene complement(2013160..2014257) /gene="bpsA" /locus_tag="BSU_22050" /old_locus_tag="BSU22050" /label="bpsA gene" promotor_-10 complement(2014275..2014286) /Source="Nicolas_upshift_promotors" /id="U1731" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=901 /SigmaFactorBS="cagtctaactccgccgcggcggagtttttttTGCATATaaaa aagattgttgCGGCACAATGTAtgcaaagaggtgatcgcatggcgtttattttatcca t" /listShort="bcsA, ypbQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2014278) /Source="Nicolas_upshifts" /id="U1731" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=901 /SigmaFactorBS="cagtctaactccgccgcggcggagtttttttTGCATATaaaa aagattgttgCGGCACAATGTAtgcaaagaggtgatcgcatggcgtttattttatcca t" /listShort="bcsA, ypbQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2014301..2014307) /Source="Nicolas_upshift_promotors" /id="U1731" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=901 /SigmaFactorBS="cagtctaactccgccgcggcggagtttttttTGCATATaaaa aagattgttgCGGCACAATGTAtgcaaagaggtgatcgcatggcgtttattttatcca t" /listShort="bcsA, ypbQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2014331..2015647) /gene="pbuX" /locus_tag="BSU_22060" /old_locus_tag="BSU22060" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9098051, 12923093, 15549109, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9098051, 12923093, 15549109, 15849754, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="xanthine permease" /protein_id="NP_390088.1" /db_xref="EnsemblGenomes-Gn:BSU22060" /db_xref="EnsemblGenomes-Tr:CAB14123" /db_xref="GOA:P42086" /db_xref="InterPro:IPR006042" /db_xref="InterPro:IPR006043" /db_xref="InterPro:IPR017588" /db_xref="SubtiList:BG11080" /db_xref="UniProtKB/Swiss-Prot:P42086" /translation="MRNGFGKTLSLGIQHVLAMYAGAIVVPLIVGKAMGLTVEQLTYL VSIDIFMCGVATLLQVWSNRFFGIGLPVVLGCTFTAVSPMIAIGSEYGVSTVYGSIIA SGILVILISFFFGKLVSFFPPVVTGSVVTIIGITLMPVAMNNMAGGEGSADFGDLSNL ALAFTVLSIIVLLYRFTKGFIKSVSILIGILIGTFIAYFMGKVQFDNVSDAAVVQMIQ PFYFGAPSFHAAPIITMSIVAIVSLVESTGVYFALGDLTNRRLTEIDLSKGYRAEGLA VLLGGIFNAFPYTAFSQNVGLVQLTGIKKNAVIVVTGVILMAFGLFPKIAAFTTIIPS AVLGGAMVAMFGMVIAYGIKMLSRIDFAKQENLLIVACSVGLGLGVTVVPDIFKQLPS ALTLLTTNGIVAGSFTAVVLNIVYNVFSKAKKIEQEADLAEQKTAV*" /label="pbuX CDS" gene complement(2014331..2015647) /gene="pbuX" /locus_tag="BSU_22060" /old_locus_tag="BSU22060" /label="pbuX gene" downshifts complement(2014344) /Source="Nicolas_upshifts" /id="D1156" /incds=0 /nref=177 /ntot=215 /MaxReadThrough="1.81377" /MaxDrop="6.3089" /score="32.8866099" /energy="-9" /TU="U1733" /idTUdmin="U1732" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2015644..2016228) /gene="xpt" /locus_tag="BSU_22070" /old_locus_tag="BSU22070" /EC_number="2.4.2.22" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12923093, 15549109, 19381559, 20108980, 20200045" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12923093, 15549109, 19381559, 20108980, 20200045; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xanthine phosphoribosyltransferase" /protein_id="NP_390089.1" /db_xref="EnsemblGenomes-Gn:BSU22070" /db_xref="EnsemblGenomes-Tr:CAB14124" /db_xref="GOA:P42085" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR010079" /db_xref="InterPro:IPR029057" /db_xref="PDB:1Y0B" /db_xref="PDB:2FXV" /db_xref="SubtiList:BG11079" /db_xref="UniProtKB/Swiss-Prot:P42085" /translation="MEALKRKIEEEGVVLSDQVLKVDSFLNHQIDPLLMQRIGDEFAS RFAKDGITKIVTIESSGIAPAVMTGLKLGVPVVFARKHKSLTLTDNLLTASVYSFTKQ TESQIAVSGTHLSDQDHVLIIDDFLANGQAAHGLVSIVKQAGASIAGIGIVIEKSFQP GRDELVKLGYRVESLARIQSLEEGKVSFVQEVHS*" /label="xpt CDS" gene complement(2015644..2016228) /gene="xpt" /locus_tag="BSU_22070" /old_locus_tag="BSU22070" /label="xpt gene" misc_RNA complement(2016317..2016417) /gene="gswA" /locus_tag="BSU_misc_RNA_34" /product="guanine riboswitch" /experiment="publication(s) with functional evidences, PMID:12787499, 15549109, 18072940, 19603494, 20022916, 20200045, 20204714, 21439477" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12787499, 15549109, 18072940, 19603494, 20022916, 20200045, 20204714, 21439477; Product type n: RNA" /label="gswA RNA" gene complement(2016317..2016417) /gene="gswA" /locus_tag="BSU_misc_RNA_34" /label="gswA gene" downshifts complement(2016324) /Source="Nicolas_upshifts" /id="D1157" /incds=0 /nref=8 /ntot=35 /MaxReadThrough="6.97435" /MaxDrop="3.25" /score="36.5247418" /energy="-19.2" /TU="U1732,U1733" /idTUdmin="U1734" /TUdmin=1870 /isTUend="FALSE" /label="downshifts" S_feature complement(2016418..2016558) /Source="Nicolas_S_feature" /locus_tag="new_2320214_2320354_c" /HighExp="dia15, BT, dia5, Diami, C90, LBGtran, Lbtran, Gly, SMMPr, M0t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.291, 0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S835" CDS complement(2016559..2018064) /gene="ypwA" /locus_tag="BSU_22080" /old_locus_tag="BSU22080" /EC_number="3.4.17.19" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7765282, 22730127; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="metal-dependent carboxypeptidase" /protein_id="NP_390090.1" /db_xref="EnsemblGenomes-Gn:BSU22080" /db_xref="EnsemblGenomes-Tr:CAB14125" /db_xref="GOA:P50848" /db_xref="InterPro:IPR001333" /db_xref="PDB:3HQ2" /db_xref="SubtiList:BG11458" /db_xref="UniProtKB/Swiss-Prot:P50848" /translation="MEIHTYEKEFFDLLKRISHYSEAVALMHWDSRTGAPKNGSEDRA ESIGQLSTDIFNIQTSDRMKELIDVLYERFDDLSEDTKKAVELAKKEYEENKKIPEAE YKEYVILCSKAETAWEEAKGKSDFSLFSPYLEQLIEFNKRFITYWGYQEHPYDALLDL FEPGVTVKVLDQLFAELKEAIIPLVKQVTASGNKPDTSFITKAFPKEKQKELSLYFLQ ELGYDFDGGRLDETVHPFATTLNRGDVRVTTRYDEKDFRTAIFGTIHECGHAIYEQNI DEALSGTNLSDGASMGIHESQSLFYENFIGRNKHFWTPYYKKIQEASPVQFKDISLDD FVRAINESKPSFIRVEADELTYPLHIIIRYEIEKAIFSNEVSVEDLPSLWNQKYQDYL GITPQTDAEGILQDVHWAGGDFGYFPSYALGYMYAAQLKQKMLEDLPEFDALLERGEF HPIKQWLTEKVHIHGKRKKPLDIIKDATGEELNVRYLIDYLSNKYSNLYLL*" /label="ypwA CDS" gene complement(2016559..2018064) /gene="ypwA" /locus_tag="BSU_22080" /old_locus_tag="BSU22080" /label="ypwA gene" promotor_no_box complement(2018000..2018100) /Source="Nicolas_upshift_promotors" /id="U1732" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.382617382617383" /psig="0.290709290709291" /xcortree=1802 /SigmaFactorBS="ctgtaatggaacggctagaatagggagggaatggatatggag atacatacatatgaaaaagaattttttgatcttttaaaaagaatctcacattacagcg a" /listShort="ypwA, S835, NA, xpt, pbuX" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(2018040) /Source="Nicolas_upshifts" /id="U1732" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.382617382617383" /psig="0.290709290709291" /xcortree=1802 /SigmaFactorBS="ctgtaatggaacggctagaatagggagggaatggatatggag atacatacatatgaaaaagaattttttgatcttttaaaaagaatctcacattacagcg a" /listShort="ypwA, S835, NA, xpt, pbuX" /GFF_Attribute="listLong" /label="upshifts" downshifts 2018052 /Source="Nicolas_upshifts" /id="D1158" /incds=0 /nref=4 /ntot=78 /MaxReadThrough="1.34397" /MaxDrop="3.87399" /score="12.6922524" /energy="-13.3" /TU="NA" /idTUdmin="U1735" /TUdmin="-5588" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2018090..2018109) /Source="Nicolas_upshift_promotors" /id="U1733" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.905094905094905" /psig="0.992007992007992" /xcortree=2219 /SigmaFactorBS="ctgccacaaaacataccggcagccttttatacaaacAATTTG ACtttcataccccctTCCATTAGCCTGTAATGGAAcggctagaatagggagggaatgg a" /listShort="ypwA, S835, NA, xpt, pbuX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2018106) /Source="Nicolas_upshifts" /id="U1733" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.905094905094905" /psig="0.992007992007992" /xcortree=2219 /SigmaFactorBS="ctgccacaaaacataccggcagccttttatacaaacAATTTG ACtttcataccccctTCCATTAGCCTGTAATGGAAcggctagaatagggagggaatgg a" /listShort="ypwA, S835, NA, xpt, pbuX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2018123..2018130) /Source="Nicolas_upshift_promotors" /id="U1733" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.905094905094905" /psig="0.992007992007992" /xcortree=2219 /SigmaFactorBS="ctgccacaaaacataccggcagccttttatacaaacAATTTG ACtttcataccccctTCCATTAGCCTGTAATGGAAcggctagaatagggagggaatgg a" /listShort="ypwA, S835, NA, xpt, pbuX" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2018176..2019168) /gene="kdgT" /locus_tag="BSU_22090" /old_locus_tag="BSU22090" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15849754, 16850406, 9846747; Product type t: transporter" /codon_start=1 /transl_table=11 /product="2-keto-3-deoxygluconate permease" /protein_id="NP_390091.1" /db_xref="EnsemblGenomes-Gn:BSU22090" /db_xref="EnsemblGenomes-Tr:CAB14126" /db_xref="GOA:P50847" /db_xref="InterPro:IPR004684" /db_xref="InterPro:IPR018395" /db_xref="SubtiList:BG11399" /db_xref="UniProtKB/Swiss-Prot:P50847" /translation="MKIKATIERVPGGMMIIPLFLGAALNTFAPGTAEFFGGFTGALI TGTLPILGVFIFCVGATIDFRSSGYIARKGITLLLGKIGFAALLGVIAAQFIPDDGIQ SGFFAGLSVLAIVAVMNETNGGLYLALMNHMGRKEDAGAFAFISTESGPFMTMVTFGV TGLAAFPWETLAATVIPFLLGCILGNLDHDLRDLFSKVVPAIIPFFAFSLGNTLNFGM LIQSGLLGIFIGVSVVILSGSSLFLLDRFIARGDGVAGVAASSTAGAAVAVPYALAEA NASFAPVAESATAIIATSVIVTSLLTPLATVWVDKKIKQKKRRTPPPKNQMTIN*" /label="kdgT CDS" gene complement(2018176..2019168) /gene="kdgT" /locus_tag="BSU_22090" /old_locus_tag="BSU22090" /label="kdgT gene" downshifts complement(2018194) /Source="Nicolas_upshifts" /id="D1159" /incds=0 /nref=15 /ntot=59 /MaxReadThrough="3.32882" /MaxDrop="5.85236" /score="36.5247418" /energy="-19.2" /TU="NA" /idTUdmin="U1734" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2019213..2019803) /gene="kdgA" /locus_tag="BSU_22100" /old_locus_tag="BSU22100" /EC_number="4.1.2.14" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9846747, 10368143; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-keto-3-deoxygluconate-6-phosphate aldolase" /protein_id="NP_390092.1" /db_xref="EnsemblGenomes-Gn:BSU22100" /db_xref="EnsemblGenomes-Tr:CAB14127" /db_xref="GOA:P50846" /db_xref="InterPro:IPR000887" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR031338" /db_xref="SubtiList:BG11396" /db_xref="UniProtKB/Swiss-Prot:P50846" /translation="MESKVVENRLKEAKLIAVIRSKDKQEACQQIESLLDKGIRAVEV TYTTPGASDIIESFRNREDILIGAGTVISAQQAGEAAKAGAQFIVSPGFSADLAEHLS FVKTHYIPGVLTPSEIMEALTFGFTTLKLFPSGVFGIPFMKNLAGPFPQVTFIPTGGI HPSEVPDWLRAGAGAVGVGSQLGSCSKEDLQAVFQV*" /label="kdgA CDS" gene complement(2019213..2019803) /gene="kdgA" /locus_tag="BSU_22100" /old_locus_tag="BSU22100" /label="kdgA gene" CDS complement(2019805..2020779) /gene="kdgK" /locus_tag="BSU_22110" /old_locus_tag="BSU22110" /EC_number="2.7.1.45" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9846747, 10368143, 15039578; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-keto-3-deoxygluconate kinase" /protein_id="NP_390093.1" /db_xref="EnsemblGenomes-Gn:BSU22110" /db_xref="EnsemblGenomes-Tr:CAB14128" /db_xref="GOA:P50845" /db_xref="InterPro:IPR002173" /db_xref="InterPro:IPR011611" /db_xref="InterPro:IPR029056" /db_xref="SubtiList:BG11397" /db_xref="UniProtKB/Swiss-Prot:P50845" /translation="MKLDAVTFGESMAMFYANEYGGLHEVSTFSKGLAGAESNVACGL ARLGFRMGWMSKVGNDQLGTFILQELKKEGVDVSRVIRSQDENPTGLLLKSKVKEGDP QVTYYRKNSAASTLTTAEYPRDYFQCAGHLHVTGIPPALSAEMKDFTYHVMNDMRNAG KTISFDPNVRPSLWPDQATMVHTINDLAGLADWFFPGIAEGELLTGEKTPEGIADYYL KKGASFVAIKLGKEGAYFKTGTSEGFLEGCRVDRVVDTVGAGDGFAVGVISGILDGLS YKDAVQRGNAIGALQVQAPGDMDGLPTREKLASFLSAQRTVHQKKGDY*" /label="kdgK CDS" gene complement(2019805..2020779) /gene="kdgK" /locus_tag="BSU_22110" /old_locus_tag="BSU22110" /label="kdgK gene" CDS complement(2020817..2021836) /gene="kdgR" /locus_tag="BSU_22120" /old_locus_tag="BSU22120" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9846747, 15223311, 17322190, 28040177" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9846747, 15223311, 17322190, 28040177; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of the Kdg operon (KdgR-galacturonate)" /protein_id="NP_390094.1" /db_xref="EnsemblGenomes-Gn:BSU22120" /db_xref="EnsemblGenomes-Tr:CAB14129" /db_xref="GOA:P50844" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR012310" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG11398" /db_xref="UniProtKB/Swiss-Prot:P50844" /translation="MKKKTTGHTTIKDVAECAGVSKSTVSRYINGKIDAISPEKVKNI KKAIAELNYRPSKMAQGLKIKKSKLIGFVVADITNPFSVAAFRGVEEVCDQYGYSIMV CNTDNSPEKEREMLLKLEAHSVEGLILNATGENKDVLRAFAEQQIPTILIDRKLPDLK LDTVTTDNRWITKEILQKVYSKGYTDVALFTEPISSISPRAERAAVYQEMASVQNVNG LVRLHEIDVKDKEQLKAELRSFHKEMPEQKKAILALNGLIMLKIISCMEELGLRIPQD IGIAGFDDTEWYKLIGPGITTIAQPSHDMGRTAMERVLKRIEGDKGAPQTIELEAKVI MRKSL*" /label="kdgR CDS" gene complement(2020817..2021836) /gene="kdgR" /locus_tag="BSU_22120" /old_locus_tag="BSU22120" /label="kdgR gene" promotor_-10 complement(2021884..2021903) /Source="Nicolas_upshift_promotors" /id="U1734" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.827172827172827" /psig=1 /xcortree=3226 /SigmaFactorBS="aaaataatgaattgacatattattaaaaaaacTCTTCCCAaa ttttaaaatTATGGTATTCTTTTGTTGTAacggttttgaaatcggtttcaaatatatg a" /listShort="kdgR, kdgK, kdgA, kdgT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2021894) /Source="Nicolas_upshifts" /id="U1734" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.827172827172827" /psig=1 /xcortree=3226 /SigmaFactorBS="aaaataatgaattgacatattattaaaaaaacTCTTCCCAaa ttttaaaatTATGGTATTCTTTTGTTGTAacggttttgaaatcggtttcaaatatatg a" /listShort="kdgR, kdgK, kdgA, kdgT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2021915..2021922) /Source="Nicolas_upshift_promotors" /id="U1734" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.827172827172827" /psig=1 /xcortree=3226 /SigmaFactorBS="aaaataatgaattgacatattattaaaaaaacTCTTCCCAaa ttttaaaatTATGGTATTCTTTTGTTGTAacggttttgaaatcggtttcaaatatatg a" /listShort="kdgR, kdgK, kdgA, kdgT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2021957..2021964 /Source="Nicolas_upshift_promotors" /id="U1735" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3227 /SigmaFactorBS="gaagagtttttttaataatatgtcaattcattattttttCGT TGACTcttttcactatttaTCCTAAAATTTTCTTTGAAAccgttaccaaaatattttc a" /listShort="S836, kduI, kduD" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2021978..2022057 /Source="Nicolas_S_feature" /locus_tag="new_2325774_2325853" /HighExp="HiTm, Heat, nit, LBGstat, ferm, T-0.40H, HiOs, T1.30H, MG 150, S0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S836" upshifts 2021978 /Source="Nicolas_upshifts" /id="U1735" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3227 /SigmaFactorBS="gaagagtttttttaataatatgtcaattcattattttttCGT TGACTcttttcactatttaTCCTAAAATTTTCTTTGAAAccgttaccaaaatattttc a" /listShort="S836, kduI, kduD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2021979..2021998 /Source="Nicolas_upshift_promotors" /id="U1735" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=3227 /SigmaFactorBS="gaagagtttttttaataatatgtcaattcattattttttCGT TGACTcttttcactatttaTCCTAAAATTTTCTTTGAAAccgttaccaaaatattttc a" /listShort="S836, kduI, kduD" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2022058..2022885 /gene="kduI" /locus_tag="BSU_22130" /old_locus_tag="BSU22130" /EC_number="5.3.1.17" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15528647, 23437267, 27227414; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase, 5-keto-4-deoxyuronate isomerase" /protein_id="NP_390095.1" /db_xref="EnsemblGenomes-Gn:BSU22130" /db_xref="EnsemblGenomes-Tr:CAB14130" /db_xref="GOA:P50843" /db_xref="InterPro:IPR007045" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR021120" /db_xref="InterPro:IPR027449" /db_xref="SubtiList:BG11401" /db_xref="UniProtKB/Swiss-Prot:P50843" /translation="MENRYSVHPEQVKRFTTEELRSHFLMDSLFTENKLTMYYSHEDR VVIGGAAPGQSELKLDAGDFLKTDFFLERREIGIINVGQPGAVRVGDDEYVLQTKDFL YIGMGNQDVSFSSLNGEKAKFYFVSACAHKSYPTQKAALSELTPDRLGDDAASNVRSL YKVIHQDGIKSCQLMMGITMLDQNNNWNTMPAHVHDRRMEAYLYLDLEKDSKVFHFMG QPDETRHLVVGNEQAVLSPAWSIHSGAGTSNYSFVWAMAGENYTFTDMDLIPMDGLK* " /label="kduI CDS" gene 2022058..2022885 /gene="kduI" /locus_tag="BSU_22130" /old_locus_tag="BSU22130" /label="kduI gene" CDS 2022887..2023651 /gene="kduD" /locus_tag="BSU_22140" /old_locus_tag="BSU22140" /EC_number="1.1.1.127" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15528647, 24509771, 27028675; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-keto-3-deoxygluconate oxidoreductase" /protein_id="NP_390096.1" /db_xref="EnsemblGenomes-Gn:BSU22140" /db_xref="EnsemblGenomes-Tr:CAB14131" /db_xref="GOA:P50842" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR011286" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11400" /db_xref="UniProtKB/Swiss-Prot:P50842" /translation="MGYLHDAFSLKGKTALVTGPGTGIGQGIAKALAGAGADIIGTSH TSSLSETQQLVEQEGRIFTSFTLDMSKPEAIKDSAAELFENRQIDILVNNAGIIHREK AEDFPEENWQHVLNVNLNSLFILTQLAGRHMLKRGHGKIINIASLLSFQGGILVPAYT ASKHAVAGLTKSFANEWAASGIQVNAIAPGYISTANTKPIRDDEKRNEDILKRIPAGR WGQADDIGGTAVFLASRASDYVNGHILAVDGGWLSR*" /label="kduD CDS" gene 2022887..2023651 /gene="kduD" /locus_tag="BSU_22140" /old_locus_tag="BSU22140" /label="kduD gene" downshifts 2023640 /Source="Nicolas_upshifts" /id="D1160" /incds=0 /nref=12 /ntot=160 /MaxReadThrough="0.66029" /MaxDrop="3.56178" /score="23.0070487" /energy="-12.3" /TU="NA" /idTUdmin="U1735" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(2023682) /Source="Nicolas_upshifts" /id="D1161" /incds=0 /nref=28 /ntot=225 /MaxReadThrough="1.88107" /MaxDrop="5.27501" /score="35.5168663" /energy="-12.3" /TU="NA" /idTUdmin="U1736" /TUdmin="-10" /isTUend="TRUE" /label="downshifts" CDS complement(2023692..2025617) /gene="ypvA" /locus_tag="BSU_22150" /old_locus_tag="BSU22150" /EC_number="3.6.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8385320, 17114254; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ATP-dependent helicase" /protein_id="NP_390097.1" /db_xref="EnsemblGenomes-Gn:BSU22150" /db_xref="EnsemblGenomes-Tr:CAB14132" /db_xref="GOA:P50831" /db_xref="InterPro:IPR006555" /db_xref="InterPro:IPR014013" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11457" /db_xref="UniProtKB/Swiss-Prot:P50831" /translation="MTTSRLPFSLTKTKNFYEELNNWIGDVFYDILPEKGFDLRDEQV FMAFQLERAFKEKKVMFAEAGVGTGKTLVYLLFAISYARYVGKPAIIACADETLIEQL VKKEGDISKLAEHLDLKIDTRLSKSHEQYLCLKKLEKTMQRSDDDKWLDLYESLPSFV HESQAMQRFYPYGDRKQYANLSNEEWSDVSYDSFQDCLTCDMRHRCGLTLSRDYYRKS TDLIICSHDFYMEHVWTEESRKREGQLPLLPDHSAVVFDEGHLLEFAAQKALTYRVKQ STLELFLERLLQNDIREEFAELIEDALLANDEFFYVLSEESKEVAGSHRLEIKNDHRV KKAADELCRLLDKIGEALVFESEMYTIDQYELSVVEEYVEQMAYSLSLYQKDAISWLE KKEAESTFVVMPRTVAEVLGEKVFSKKIPYIFSSATLSEGGSFDYIADSLGIHDYLSL TVDSPYDYDEQMSINLYAKTDMDAEQKTAETIETIKRYKGRTLVLFPSFEELNEFKEL SAAWELPYPIFFEGDEEISSLVEKFQEEEETVLCSVHLWEGLDIPGDALKNVTIWSLP FPPHDPVFTAKRNGAKKDPFEEVDLPYMLLRVRQGIGRLIRSNQDSGSIHIYAGGENE RIIDEVKKVLPVEPHMM*" /label="ypvA CDS" gene complement(2023692..2025617) /gene="ypvA" /locus_tag="BSU_22150" /old_locus_tag="BSU22150" /label="ypvA gene" promotor_-10 complement(2025648..2025667) /Source="Nicolas_upshift_promotors" /id="U1736" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.53946053946054" /psig=1 /xcortree=2498 /SigmaFactorBS="aaaaacttggcattgccaagttttttATTGTattcatcagcg gaaAATGATATTATTGGTGGTCTgaatgtcgaatagttgggggttggaactaggtgac a" /listShort="ypvA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2025652) /Source="Nicolas_upshifts" /id="U1736" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.53946053946054" /psig=1 /xcortree=2498 /SigmaFactorBS="aaaaacttggcattgccaagttttttATTGTattcatcagcg gaaAATGATATTATTGGTGGTCTgaatgtcgaatagttgggggttggaactaggtgac a" /listShort="ypvA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2025654..2025718) /Source="Nicolas_S_feature" /locus_tag="new_2329450_2329514_c" /HighExp="S3, S4, S8, S7, LoTm, S5, S6, BT, G180, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="0.999, 1" /TUlongSig="SigA, SigA, SigA, SigA" /TUlongPSig="0.998, 1, 0.998, 1" /label="S837" promotor_-35 complement(2025682..2025686) /Source="Nicolas_upshift_promotors" /id="U1736" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.53946053946054" /psig=1 /xcortree=2498 /SigmaFactorBS="aaaaacttggcattgccaagttttttATTGTattcatcagcg gaaAATGATATTATTGGTGGTCTgaatgtcgaatagttgggggttggaactaggtgac a" /listShort="ypvA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2025719..2025910) /gene="yptA" /locus_tag="BSU_22160" /old_locus_tag="BSU22160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_390098.1" /db_xref="EnsemblGenomes-Gn:BSU22160" /db_xref="EnsemblGenomes-Tr:CAB14133" /db_xref="SubtiList:BG11456" /db_xref="UniProtKB/Swiss-Prot:P50841" /translation="MLNSEHFNLIQRALDATANELKELGTDSSPSVISHAQTDLEKAV EHIYSTDHPFLSSHVINRK*" /label="yptA CDS" gene complement(2025719..2025910) /gene="yptA" /locus_tag="BSU_22160" /old_locus_tag="BSU22160" /label="yptA gene" promotor_-10 complement(2025929..2025947) /Source="Nicolas_upshift_promotors" /id="U1737" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1119 /SigmaFactorBS="catgtttcggtgataacatgcggtaaagcaTGTATAtaaaat gaaaagttcGCATACAATGATGATTATTtccatcagaggtgatctcatgctgaacagc g" /listShort="yptA, S837, ypvA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2025938) /Source="Nicolas_upshifts" /id="U1737" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1119 /SigmaFactorBS="catgtttcggtgataacatgcggtaaagcaTGTATAtaaaat gaaaagttcGCATACAATGATGATTATTtccatcagaggtgatctcatgctgaacagc g" /listShort="yptA, S837, ypvA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2025940..2026245) /Source="Nicolas_S_feature" /locus_tag="new_2329736_2330041_c" /HighExp="Cold, G135, G180, C30, G150, Oxctl, Paraq, H2O2, LBGstat, LPh" /AntisenseName="ypzG" /AntisenseCor="-0.39420155633160697" /AntisenseRegPval="-10.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA, SigA, SigA" /TUlongPSig="0.998, 1, 0.998, 1" /label="S838" promotor_-35 complement(2025963..2025968) /Source="Nicolas_upshift_promotors" /id="U1737" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1119 /SigmaFactorBS="catgtttcggtgataacatgcggtaaagcaTGTATAtaaaat gaaaagttcGCATACAATGATGATTATTtccatcagaggtgatctcatgctgaacagc g" /listShort="yptA, S837, ypvA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2025977..2025983 /Source="Nicolas_upshift_promotors" /id="U1738" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=859 /SigmaFactorBS="cgaacttttcattttatatacatgctttacCGCATGTtatca ccgaaacatGCACAAACTACActtgatattccgtctccggattatccgtcttatcaac a" /listShort="ypzG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2025998..2026009 /Source="Nicolas_upshift_promotors" /id="U1738" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=859 /SigmaFactorBS="cgaacttttcattttatatacatgctttacCGCATGTtatca ccgaaacatGCACAAACTACActtgatattccgtctccggattatccgtcttatcaac a" /listShort="ypzG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2026007 /Source="Nicolas_upshifts" /id="U1738" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=859 /SigmaFactorBS="cgaacttttcattttatatacatgctttacCGCATGTtatca ccgaaacatGCACAAACTACActtgatattccgtctccggattatccgtcttatcaac a" /listShort="ypzG" /GFF_Attribute="listLong" /label="upshifts" CDS 2026074..2026226 /gene="ypzG" /locus_tag="BSU_22169" /old_locus_tag="BSU22169" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097754.1" /db_xref="EnsemblGenomes-Gn:BSU22169" /db_xref="EnsemblGenomes-Tr:CAX52653" /db_xref="InterPro:IPR025413" /db_xref="UniProtKB/Swiss-Prot:C0H444" /translation="MSYRNRLDQHSELFHHNWTRPKRSKSQVNGHTEMSQTNIILRSN AKAHRW*" /label="ypzG CDS" gene 2026074..2026226 /gene="ypzG" /locus_tag="BSU_22169" /old_locus_tag="BSU22169" /label="ypzG gene" downshifts 2026236 /Source="Nicolas_upshifts" /id="D1162" /incds=0 /nref=35 /ntot=65 /MaxReadThrough="1.2837" /MaxDrop="7.64655" /score="-9.36260071" /energy="-16.3" /TU="NA" /idTUdmin="U1738" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2026279..2027436) /gene="rlmKB" /locus_tag="BSU_22170" /old_locus_tag="BSU22170" /EC_number="2.1.1.264" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 22210896, 22362734; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="m(7)G2069 methylase of 23S rRNA" /protein_id="NP_390099.1" /db_xref="EnsemblGenomes-Gn:BSU22170" /db_xref="EnsemblGenomes-Tr:CAB14134" /db_xref="GOA:P50840" /db_xref="InterPro:IPR000241" /db_xref="InterPro:IPR002052" /db_xref="InterPro:IPR004114" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11455" /db_xref="UniProtKB/Swiss-Prot:P50840" /translation="MKKYTLIATAPMGIEAVVAKEVRDLGYECKVDNGKVIFEGDALA ICRANLWLRTADRIKVQVASFKAKTFDELFEKTKAINWRSFIPENGKFPVIGKSVKST LASVPDCQRIVKKAIVEKLKLQSGKANDWIEETGAEYKVEISLLKDQALITLDSSGTG LHKRGYRVDQGGAPIKETLAAALVQLTNWTPDRPFVDPFCGSGTIAIEAALIGQNIAP GFNRDFVSEDWEWIGKDLWNKARLEVEEKANYDQPLTIFASDIDHRMVQIAKENAEEA GLGDLIQFKQMQVKDFTTNLEFGVIVGNPPYGERLGEKKAVEQMYKEMGQAFEPLDTW SVYMLTSNENFEEAYGRKATKKRKLFNGFIKTDYYQYWSKVRPQRKKTENA*" /label="rlmKB CDS" gene complement(2026279..2027436) /gene="rlmKB" /locus_tag="BSU_22170" /old_locus_tag="BSU22170" /label="rlmKB gene" downshifts complement(2026290) /Source="Nicolas_upshifts" /id="D1163" /incds=0 /nref=86 /ntot=240 /MaxReadThrough="4.31441" /MaxDrop="4.58268" /score="14.6684819" /energy="-6.2" /TU="U1739" /idTUdmin="U1740" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_RNA complement(2027524..2027924) /gene="rnpB" /locus_tag="BSU_misc_RNA_35" /product="RNA component of ribonuclease P (RNase P) (catalytic subunit, ribozyme)" /experiment="publication(s) with functional evidences, PMID:1699929, 16980484, 17919279, 22448220" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1699929, 16980484, 17919279, 22448220; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rnpB RNA" gene complement(2027524..2027924) /gene="rnpB" /locus_tag="BSU_misc_RNA_35" /label="rnpB gene" downshifts complement(2027534) /Source="Nicolas_upshifts" /id="D1164" /incds=0 /nref=200 /ntot=276 /MaxReadThrough="6.17541" /MaxDrop="7.4677" /score="0.20729905" /energy="-10.4" /TU="U1739,U1740" /idTUdmin="U1742" /TUdmin=406 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2027921..2027940) /Source="Nicolas_upshift_promotors" /id="U1739" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.684315684315684" /psig=1 /xcortree=288 /SigmaFactorBS="gcaagctttatgattgatcacgcttgaaaaaaatggcgCTTG TAAattgtaatcagttgTTATATAATAATTCATGTTCttaacgttcgggtaatcgctg c" /listShort="rnpB, ypsC, S838, yptA, S837, ypvA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2027939) /Source="Nicolas_upshifts" /id="U1739" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.684315684315684" /psig=1 /xcortree=288 /SigmaFactorBS="gcaagctttatgattgatcacgcttgaaaaaaatggcgCTTG TAAattgtaatcagttgTTATATAATAATTCATGTTCttaacgttcgggtaatcgctg c" /listShort="rnpB, ypsC, S838, yptA, S837, ypvA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2027955..2027961) /Source="Nicolas_upshift_promotors" /id="U1739" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.684315684315684" /psig=1 /xcortree=288 /SigmaFactorBS="gcaagctttatgattgatcacgcttgaaaaaaatggcgCTTG TAAattgtaatcagttgTTATATAATAATTCATGTTCttaacgttcgggtaatcgctg c" /listShort="rnpB, ypsC, S838, yptA, S837, ypvA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2027983..2028279) /gene="gpsB" /locus_tag="BSU_22180" /old_locus_tag="BSU22180" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:18363795, 18776011, 19429628, 25845974, 27257764" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18363795, 18776011, 19429628, 25845974, 27257764; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="cell division protein" /protein_id="NP_390100.1" /db_xref="EnsemblGenomes-Gn:BSU22180" /db_xref="EnsemblGenomes-Tr:CAB14135" /db_xref="GOA:P0CI74" /db_xref="InterPro:IPR007793" /db_xref="InterPro:IPR011229" /db_xref="InterPro:IPR019933" /db_xref="PDB:4UG3" /db_xref="PDB:5AN5" /db_xref="SubtiList:BG11454" /db_xref="UniProtKB/Swiss-Prot:P0CI74" /translation="MLADKVKLSAKEILEKEFKTGVRGYKQEDVDKFLDMIIKDYETF HQEIEELQQENLQLKKQLEEASKKQPVQSNTTNFDILKRLSNLEKHVFGSKLYD*" /label="gpsB CDS" gene complement(2027983..2028279) /gene="gpsB" /locus_tag="BSU_22180" /old_locus_tag="BSU22180" /label="gpsB gene" promotor_-10 complement(2028304..2028323) /Source="Nicolas_upshift_promotors" /id="U1740" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.712287712287712" /psig="0.998001998001998" /xcortree=3143 /SigmaFactorBS="gaggaagacagctactaacaatgagagagaAATTTGACaacc gtacagattTCTGAAAAAATATATGTGATgattcacgatacgaggtgaaaaagatgct t" /listShort="gpsB, rnpB, ypsC" /listLong="S838, yptA, S837, ypvA" /label="promotor_-10" upshifts complement(2028314) /Source="Nicolas_upshifts" /id="U1740" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.712287712287712" /psig="0.998001998001998" /xcortree=3143 /SigmaFactorBS="gaggaagacagctactaacaatgagagagaAATTTGACaacc gtacagattTCTGAAAAAATATATGTGATgattcacgatacgaggtgaaaaagatgct t" /listShort="gpsB, rnpB, ypsC" /listLong="S838, yptA, S837, ypvA" /label="upshifts" promotor_-35 complement(2028337..2028344) /Source="Nicolas_upshift_promotors" /id="U1740" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.712287712287712" /psig="0.998001998001998" /xcortree=3143 /SigmaFactorBS="gaggaagacagctactaacaatgagagagaAATTTGACaacc gtacagattTCTGAAAAAATATATGTGATgattcacgatacgaggtgaaaaagatgct t" /listShort="gpsB, rnpB, ypsC" /listLong="S838, yptA, S837, ypvA" /label="promotor_-35" CDS complement(2028357..2028986) /gene="ypsA" /locus_tag="BSU_22190" /old_locus_tag="BSU22190" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390101.2" /db_xref="EnsemblGenomes-Gn:BSU22190" /db_xref="EnsemblGenomes-Tr:CAB14136" /db_xref="InterPro:IPR010697" /db_xref="PDB:2NX2" /db_xref="SubtiList:BG11453" /db_xref="UniProtKB/Swiss-Prot:P50838" /translation="MENVQLDGVNNAAQQMGPTGAPFFKAGEMMKVLAITGYKPFELG IFKQDDKALYYIKKAIKNRLIAFLDEGLEWILISGQLGVELWAAEAAYDLQEEYPDLK VAVITPFYEQEKNWKEPNKEQYEAVLAQADYEASLTHRPYESPLQFKQKNQFFIDKSD GLLLLYDPEKEGSPKYMLGTAEKRREQDGYPIYFITMDDLRVTVEEDSY*" /label="ypsA CDS" gene complement(2028357..2028986) /gene="ypsA" /locus_tag="BSU_22190" /old_locus_tag="BSU22190" /label="ypsA gene" downshifts complement(2028952) /Source="Nicolas_upshifts" /id="D1165" /incds=0 /nref=37 /ntot=160 /MaxReadThrough="5.74028" /MaxDrop="8.12374" /score="7.18626302" /energy="-9.8" /TU="U1741,U1742" /idTUdmin="U1744" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2028988..2029215) /gene="cotD" /locus_tag="BSU_22200" /old_locus_tag="BSU22200" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:2821284, 10075739, 10400595, 1518043, 1691789, 19933362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2821284, 10075739, 10400595, 1518043, 1691789, 19933362; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="spore coat protein (inner)" /protein_id="NP_390102.1" /db_xref="EnsemblGenomes-Gn:BSU22200" /db_xref="EnsemblGenomes-Tr:CAB14137" /db_xref="GOA:P07791" /db_xref="InterPro:IPR020108" /db_xref="SubtiList:BG10493" /db_xref="UniProtKB/Swiss-Prot:P07791" /translation="MHHCRPHMMAPIVHPTHCCEHHTFSKTIVPHIHPQHTTNVNHQH FQHVHYFPHTFSNVDPATHQHFQAGKPCCDY*" /label="cotD CDS" gene complement(2028988..2029215) /gene="cotD" /locus_tag="BSU_22200" /old_locus_tag="BSU22200" /label="cotD gene" promotor_-10 complement(2029243..2029262) /Source="Nicolas_upshift_promotors" /id="U1741" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1359 /SigmaFactorBS="gcttaattgcacacttttaaaataggtctttgcaTCAGAACA TgtaccccttatttTTCATAACTTAGTATTGTAAtaaagtttatggaaaggggatttt a" /listShort="cotD, ypsA" /listLong="gpsB, rnpB, ypsC" /label="promotor_-10" upshifts complement(2029258) /Source="Nicolas_upshifts" /id="U1741" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1359 /SigmaFactorBS="gcttaattgcacacttttaaaataggtctttgcaTCAGAACA TgtaccccttatttTTCATAACTTAGTATTGTAAtaaagtttatggaaaggggatttt a" /listShort="cotD, ypsA" /listLong="gpsB, rnpB, ypsC" /label="upshifts" S_feature complement(2029260..2029414) /Source="Nicolas_S_feature" /locus_tag="new_2333056_2333210_c" /HighExp="LBGexp, dia15, Paraq, H2O2, Heat, G135, UNK1, Lbexp, BMM, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.808141" /TUshortSig="SigA, Sig-, SigA, SigA" /TUshortPSig="1, 0.419, 0.998, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S839" promotor_-35 complement(2029276..2029284) /Source="Nicolas_upshift_promotors" /id="U1741" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1359 /SigmaFactorBS="gcttaattgcacacttttaaaataggtctttgcaTCAGAACA TgtaccccttatttTTCATAACTTAGTATTGTAAtaaagtttatggaaaggggatttt a" /listShort="cotD, ypsA" /listLong="gpsB, rnpB, ypsC" /label="promotor_-35" CDS complement(2029299..2029427) /locus_tag="BSU_22205" /old_locus_tag="BSU22205" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_009513975.1" /translation="MTLVIFKGRVGMYKGVFYLFFVVVFLIAFVFSNFKDSLIAHF*" /label="conserved protein of unknown function CDS" gene complement(2029299..2029427) /locus_tag="BSU_22205" /old_locus_tag="BSU22205" /label="gene" upshifts complement(2029414) /Source="Nicolas_upshifts" /id="U1742" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.592407592407592" /psig=1 /xcortree=2670 /SigmaFactorBS="ctgaattcacattgatttTGTTGtagaatagcggcgaaTCCT GTAAAATGACGTTAGTtatttttaaagggagagttggtatgtataagggtgtttttta c" /listShort="S839, cotD, ypsA, gpsB" /listLong="rnpB, ypsC, S838, yptA, S837, ypvA" /label="upshifts" S_feature complement(2029416..2029527) /Source="Nicolas_S_feature" /locus_tag="new_2333212_2333323_c" /HighExp="Sw, M40t90, Etha, Salt, M40t45, H2O2, S8, S6, G135, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, SigA" /TUshortPSig="0.419, 0.998, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S840" promotor_-10 complement(2029417..2029436) /Source="Nicolas_upshift_promotors" /id="U1742" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.592407592407592" /psig=1 /xcortree=2670 /SigmaFactorBS="ctgaattcacattgatttTGTTGtagaatagcggcgaaTCCT GTAAAATGACGTTAGTtatttttaaagggagagttggtatgtataagggtgtttttta c" /listShort="S839, cotD, ypsA, gpsB" /listLong="rnpB, ypsC, S838, yptA, S837, ypvA" /label="promotor_-10" promotor_-35 complement(2029452..2029456) /Source="Nicolas_upshift_promotors" /id="U1742" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.592407592407592" /psig=1 /xcortree=2670 /SigmaFactorBS="ctgaattcacattgatttTGTTGtagaatagcggcgaaTCCT GTAAAATGACGTTAGTtatttttaaagggagagttggtatgtataagggtgtttttta c" /listShort="S839, cotD, ypsA, gpsB" /listLong="rnpB, ypsC, S838, yptA, S837, ypvA" /label="promotor_-35" CDS complement(2029528..2030769) /gene="yprB" /locus_tag="BSU_22210" /old_locus_tag="BSU22210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23249255; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative nucleic acid binding enzyme" /protein_id="NP_390103.1" /db_xref="EnsemblGenomes-Gn:BSU22210" /db_xref="EnsemblGenomes-Tr:CAB14138" /db_xref="GOA:P50837" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG11452" /db_xref="UniProtKB/Swiss-Prot:P50837" /translation="MSLKGKLQRMKKHMALDEGEQKIEAGKQENHFDDIPFLEEWEAF GMKPFIFEDEYCLIREVEYPLSHRHGLYSFSELEEVITLWNQSGLSHTLSAKGYNKNN LFFFDTETTGLGGGAGNTIFLLGHARVYEDRVTVKQHLLPKPGNEVALYQSFLSEVDI TSLVTYNGKAFDWPQVKTRHTLIRDRLPKLPEFGHFDLLHGARRLWKHKMDRVSLGTV EKEELGIRRLEDTPGYLAPMLYFHFIKAQEPDLLKGVLHHNEMDVLSLISLYIHMSKK ILSESHAPKEHSEAYAMAKWFMAHKETDQAIKQLERLIEKSFEDQDSARLDLSLLYKK QNRLEEAVPLWEKLSRSQNQKCRYAAVIELAKYFEHKKKEFGKALQVAEQSLSDAACL SEKETEKLHVRIARLKRKYSS*" /label="yprB CDS" gene complement(2029528..2030769) /gene="yprB" /locus_tag="BSU_22210" /old_locus_tag="BSU22210" /label="yprB gene" promotor_-10 complement(2030483..2030501) /Source="Nicolas_upshift_promotors" /id="U1743" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.418581418581419" /psig="0.418581418581419" /xcortree=723 /SigmaFactorBS="gcttttctgagcttgaggaagtgatcacaCTGTGGAAtcaaa gcggcctgtCGCATACATTGTCAGCAAAagggtataacaaaaacaacctctttttctt t" /listShort="S840, S839" /listLong="cotD" /label="promotor_-10" upshifts complement(2030492) /Source="Nicolas_upshifts" /id="U1743" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.418581418581419" /psig="0.418581418581419" /xcortree=723 /SigmaFactorBS="gcttttctgagcttgaggaagtgatcacaCTGTGGAAtcaaa gcggcctgtCGCATACATTGTCAGCAAAagggtataacaaaaacaacctctttttctt t" /listShort="S840, S839" /listLong="cotD" /label="upshifts" promotor_-35 complement(2030516..2030523) /Source="Nicolas_upshift_promotors" /id="U1743" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.418581418581419" /psig="0.418581418581419" /xcortree=723 /SigmaFactorBS="gcttttctgagcttgaggaagtgatcacaCTGTGGAAtcaaa gcggcctgtCGCATACATTGTCAGCAAAagggtataacaaaaacaacctctttttctt t" /listShort="S840, S839" /listLong="cotD" /label="promotor_-35" CDS complement(2030785..2033034) /gene="yprA" /locus_tag="BSU_22220" /old_locus_tag="BSU22220" /EC_number="3.6.4.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16267290; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ATP-dependent RNA helicase" /protein_id="NP_390104.1" /db_xref="EnsemblGenomes-Gn:BSU22220" /db_xref="EnsemblGenomes-Tr:CAB14139" /db_xref="GOA:P50830" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR018973" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11451" /db_xref="UniProtKB/Swiss-Prot:P50830" /translation="MKKKSLTELISDLKGNENVVNWHEIEPREAKTRPMPESIDERIK AALSKRGIDELYTHQYSAFQYVQKGESIVTVTPTASGKTLCYNLPVLQSIAQDETNRA LYLFPTKALAQDQKSELNEIIDEMGIDIKSFTYDGDTSPAIRQKVRKAGHIVITNPDM LHSAILPHHTKWVSLFENLKYIVIDELHTYRGVFGSHVANVIRRLKRICRFYGSDPVF ICTSATIANPKELGEQLTGKPMRLVDDNGAPSGRKHFVFYNPPIVNKPLNIRRSATAE VNELAKEFLKNKVQTIVFARSRVRVEIILSHIQELVKKEIGTKSIRGYRGGYLPKERR EIERGLREGDILGVVSTNALELGVDIGQLQVCVMTGYPGSVASAWQQAGRAGRRHGES LIIMVANSTPIDQYIVRHPEYFFNRSPESARINPENLIILVDHLKCAAYELPFRADEE FGAMEVSDILEYLQEEAVLHRNGERYHWASESFPASNISLRSASQENVVIVDQSDIAN VRIIGEMDRFSAMTLLHDEAIYLHEGVQYQVEKLDWDHKKAYVRKVDVEYYTDANLAV QLKVLEIDKTKEKSRTSLHYGDVTVNALPTIFKKIKMTTFENIGSGPIHLPEEELHTS AAWLEIKTADEDIGEKTLEQLLLGISNVLQHIVPVYIMCDRNDVHVVSQIKAAHTGLP TIFLYDHYPGGIGLAEEVFKRFSDINEAAKQLITHCPCHDGCPSCIGTEIEGIKAKER ILQLLDQMS*" /label="yprA CDS" gene complement(2030785..2033034) /gene="yprA" /locus_tag="BSU_22220" /old_locus_tag="BSU22220" /label="yprA gene" promotor_-10 complement(2033050..2033069) /Source="Nicolas_upshift_promotors" /id="U1744" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.362637362637363" /psig="0.998001998001998" /xcortree=2675 /SigmaFactorBS="tgccttgctttttttattcaactgtataaaatttgcaCCTAG CCatgcaaacaaataTTCGGTAAACTGTACTTGACaaagaggtgtaaagaatgaaaaa g" /listShort="yprA, yprB, S840, S839, cotD" /listLong="ypsA, gpsB, rnpB, ypsC, S838, yptA, S837, ypvA" /label="promotor_-10" upshifts complement(2033066) /Source="Nicolas_upshifts" /id="U1744" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.362637362637363" /psig="0.998001998001998" /xcortree=2675 /SigmaFactorBS="tgccttgctttttttattcaactgtataaaatttgcaCCTAG CCatgcaaacaaataTTCGGTAAACTGTACTTGACaaagaggtgtaaagaatgaaaaa g" /listShort="yprA, yprB, S840, S839, cotD" /listLong="ypsA, gpsB, rnpB, ypsC, S838, yptA, S837, ypvA" /label="upshifts" promotor_-35 complement(2033083..2033089) /Source="Nicolas_upshift_promotors" /id="U1744" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.362637362637363" /psig="0.998001998001998" /xcortree=2675 /SigmaFactorBS="tgccttgctttttttattcaactgtataaaatttgcaCCTAG CCatgcaaacaaataTTCGGTAAACTGTACTTGACaaagaggtgtaaagaatgaaaaa g" /listShort="yprA, yprB, S840, S839, cotD" /listLong="ypsA, gpsB, rnpB, ypsC, S838, yptA, S837, ypvA" /label="promotor_-35" CDS complement(2033137..2033643) /gene="ypqE" /locus_tag="BSU_22230" /old_locus_tag="BSU22230" /EC_number="2.7.1.-" /function="16.1: Circulate" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10627040, 28731580; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphotransferase system enzyme IIA component" /protein_id="NP_390105.1" /db_xref="EnsemblGenomes-Gn:BSU22230" /db_xref="EnsemblGenomes-Tr:CAB14140" /db_xref="GOA:P50829" /db_xref="InterPro:IPR001127" /db_xref="InterPro:IPR011055" /db_xref="SubtiList:BG11450" /db_xref="UniProtKB/Swiss-Prot:P50829" /translation="MLKKLFGMGKIQEKVTEEVIYSPADGTVMDLSDVPDPVFSQKMM GEGIAVEPSSGEIVSPAEGEVIQIFHTKHAVGIRTRSGIELLIHVGLETVNMNGEGFT AHIKEGDKVKVGDPLITCDLELIKEKASSTVIPIVIMNGEAVGSMVSAGEKAARKGES KLFTIKAK*" /label="ypqE CDS" gene complement(2033137..2033643) /gene="ypqE" /locus_tag="BSU_22230" /old_locus_tag="BSU22230" /label="ypqE gene" downshifts complement(2033160) /Source="Nicolas_upshifts" /id="D1166" /incds=0 /nref=88 /ntot=236 /MaxReadThrough="4.55156" /MaxDrop="6.1724" /score="32.5355561" /energy="-10.2" /TU="U1745" /idTUdmin="U1747" /TUdmin=808 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2033687..2033706) /Source="Nicolas_upshift_promotors" /id="U1745" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.704295704295704" /psig=1 /xcortree=3134 /SigmaFactorBS="tttaaccagattatgcgtctatgccagatgttgttatAAATT GAAgcaaaattgaaagTGTGGTTAAATAGTGGTGAAtgaagggataacggttgaagtg a" /listShort="ypqE, yprA, yprB, S840, S839, cotD" /listLong="ypsA, gpsB, rnpB, ypsC, S838, yptA, S837, ypvA" /label="promotor_-10" upshifts complement(2033704) /Source="Nicolas_upshifts" /id="U1745" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.704295704295704" /psig=1 /xcortree=3134 /SigmaFactorBS="tttaaccagattatgcgtctatgccagatgttgttatAAATT GAAgcaaaattgaaagTGTGGTTAAATAGTGGTGAAtgaagggataacggttgaagtg a" /listShort="ypqE, yprA, yprB, S840, S839, cotD" /listLong="ypsA, gpsB, rnpB, ypsC, S838, yptA, S837, ypvA" /label="upshifts" promotor_-35 complement(2033720..2033727) /Source="Nicolas_upshift_promotors" /id="U1745" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.704295704295704" /psig=1 /xcortree=3134 /SigmaFactorBS="tttaaccagattatgcgtctatgccagatgttgttatAAATT GAAgcaaaattgaaagTGTGGTTAAATAGTGGTGAAtgaagggataacggttgaagtg a" /listShort="ypqE, yprA, yprB, S840, S839, cotD" /listLong="ypsA, gpsB, rnpB, ypsC, S838, yptA, S837, ypvA" /label="promotor_-35" promotor_-35 2033725..2033734 /Source="Nicolas_upshift_promotors" /id="U1746" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1340 /SigmaFactorBS="aaccacactttcaattttgcttcaaTTTATAACAAcatctgg catagaCGCATAATCTGGTTAAAAAAggcggtggcgatattggaattccatgatgaca a" /listShort="ypqA, S841" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2033748..2033767 /Source="Nicolas_upshift_promotors" /id="U1746" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1340 /SigmaFactorBS="aaccacactttcaattttgcttcaaTTTATAACAAcatctgg catagaCGCATAATCTGGTTAAAAAAggcggtggcgatattggaattccatgatgaca a" /listShort="ypqA, S841" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2033760 /Source="Nicolas_upshifts" /id="U1746" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1340 /SigmaFactorBS="aaccacactttcaattttgcttcaaTTTATAACAAcatctgg catagaCGCATAATCTGGTTAAAAAAggcggtggcgatattggaattccatgatgaca a" /listShort="ypqA, S841" /GFF_Attribute="listLong" /label="upshifts" CDS 2033781..2034200 /gene="ypqA" /locus_tag="BSU_22240" /old_locus_tag="BSU22240" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative chaperone" /protein_id="NP_390106.1" /db_xref="EnsemblGenomes-Gn:BSU22240" /db_xref="EnsemblGenomes-Tr:CAB14141" /db_xref="InterPro:IPR008978" /db_xref="SubtiList:BG11449" /db_xref="UniProtKB/Swiss-Prot:P50836" /translation="MEFHDDKKNELQKKEEIITEAIDTLFQSSAFGNLINGFQNLINS SLKDVQTTIHVRERDTGLYIDITIPATFRDGEIVVDVKSRYLHVTLQEKQKHQNEATF TSMTRTVQLPYEVRQEDMETSWNEQTMTLFFPKNKHE*" /label="ypqA CDS" gene 2033781..2034200 /gene="ypqA" /locus_tag="BSU_22240" /old_locus_tag="BSU22240" /label="ypqA gene" S_feature 2034201..2034351 /Source="Nicolas_S_feature" /locus_tag="new_2337997_2338147" /HighExp="S6, S8, S7, BT, S5, B36, B60, Pyr, G/S, nit" /AntisenseName="yppG" /AntisenseCor="0.95679380325708796" /AntisenseRegPval="-144.5" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S841" CDS complement(2034221..2034598) /gene="yppG" /locus_tag="BSU_22250" /old_locus_tag="BSU22250" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22882546; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative spore coat protein; methionine-glutamine-rich protein" /protein_id="NP_390107.1" /db_xref="EnsemblGenomes-Gn:BSU22250" /db_xref="EnsemblGenomes-Tr:CAB14142" /db_xref="InterPro:IPR025555" /db_xref="SubtiList:BG11448" /db_xref="UniProtKB/Swiss-Prot:P50835" /translation="MNGSSRSYPRQMGYYYPQHMQGYYQQAAPGYLEQQLPQQHYGQQ DYYQPYAPIQPMPMQPPVFSNPYPIPRPNQQQPSQFQSIMSQFKKANGQFDFNKMMDT TGQVMSAMNQVGSLIKGFTSFFK*" /label="yppG CDS" gene complement(2034221..2034598) /gene="yppG" /locus_tag="BSU_22250" /old_locus_tag="BSU22250" /label="yppG gene" downshifts complement(2034254) /Source="Nicolas_upshifts" /id="D1167" /incds=0 /nref=10 /ntot=43 /MaxReadThrough="3.01854" /MaxDrop="4.7006" /score="0.85617333" /energy="-12.8" /TU="U1747" /idTUdmin="U1747" /TUdmin="-286" /isTUend="FALSE" /label="downshifts" S_feature 2034596..2034741 /Source="Nicolas_S_feature" /locus_tag="new_2338392_2338537" /HighExp="S6, S8, S7, BT, S5, B36, B60, Pyr, G/S, C30" /AntisenseName="yppG" /AntisenseCor="0.96504903995490698" /AntisenseRegPval="-156.6" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S842" promotor_-10 complement(2034628..2034646) /Source="Nicolas_upshift_promotors" /id="U1747" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1321 /SigmaFactorBS="aactttcgacacaatttgacaaatgctaatcatcacttGTGA CACAAAcaatagaagtcatTCATACATATATAGAAGAGaaatatgttgtgtttagggg g" /listShort="yppG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2034647) /Source="Nicolas_upshifts" /id="U1747" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1321 /SigmaFactorBS="aactttcgacacaatttgacaaatgctaatcatcacttGTGA CACAAAcaatagaagtcatTCATACATATATAGAAGAGaaatatgttgtgtttagggg g" /listShort="yppG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2034660..2034669) /Source="Nicolas_upshift_promotors" /id="U1747" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1321 /SigmaFactorBS="aactttcgacacaatttgacaaatgctaatcatcacttGTGA CACAAAcaatagaagtcatTCATACATATATAGAAGAGaaatatgttgtgtttagggg g" /listShort="yppG" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 2034742..2034761 /Source="Nicolas_upshift_promotors" /id="U1748" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.896103896103896" /psig="0.994005994005994" /xcortree=2721 /SigmaFactorBS="catttgtcaaattgtgtcgaaagtttaaattttttaaaaaca gaaaaaagtcgaatcatTATGGTACCATATTTTCAATacagatgagaggggatgcacc a" /listShort="yppF" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2034743 /Source="Nicolas_upshifts" /id="U1748" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.896103896103896" /psig="0.994005994005994" /xcortree=2721 /SigmaFactorBS="catttgtcaaattgtgtcgaaagtttaaattttttaaaaaca gaaaaaagtcgaatcatTATGGTACCATATTTTCAATacagatgagaggggatgcacc a" /listShort="yppF" /GFF_Attribute="listLong" /label="upshifts" CDS 2034786..2034974 /gene="yppF" /locus_tag="BSU_22260" /old_locus_tag="BSU22260" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735, 22882546; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative sporulation protein" /protein_id="NP_390108.1" /db_xref="EnsemblGenomes-Gn:BSU22260" /db_xref="EnsemblGenomes-Tr:CAB14143" /db_xref="InterPro:IPR025553" /db_xref="SubtiList:BG11447" /db_xref="UniProtKB/Swiss-Prot:P50834" /translation="MNVSYLSKRFAEMKKYETDCMNKLMDFAKFLYIQGHLSITEFRN SMKVLEANGAESPAYEMN*" /label="yppF CDS" gene 2034786..2034974 /gene="yppF" /locus_tag="BSU_22260" /old_locus_tag="BSU22260" /label="yppF gene" downshifts 2034990 /Source="Nicolas_upshifts" /id="D1168" /incds=0 /nref=112 /ntot=242 /MaxReadThrough="3.3677" /MaxDrop="5.69944" /score="0.283992322" /energy="-8.5" /TU="U1748" /idTUdmin="U1748" /TUdmin="-200" /isTUend="FALSE" /label="downshifts" CDS complement(2035013..2035384) /gene="yppE" /locus_tag="BSU_22270" /old_locus_tag="BSU22270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390109.1" /db_xref="EnsemblGenomes-Gn:BSU22270" /db_xref="EnsemblGenomes-Tr:CAB14144" /db_xref="InterPro:IPR014913" /db_xref="InterPro:IPR023351" /db_xref="PDB:2HFI" /db_xref="PDB:2IM8" /db_xref="SubtiList:BG11446" /db_xref="UniProtKB/Swiss-Prot:P50833" /translation="MLSQTLLEMTEQMIEVAEKGADRYQEGKNSNHSYDFFETIKPAV EENDELAARWAEGALELIKVRRPKYVHKEQIEAVKDNFLELVLQSYVHHIHKKRFKDI TESVLYTLHAVKDEIAREDSR*" /label="yppE CDS" gene complement(2035013..2035384) /gene="yppE" /locus_tag="BSU_22270" /old_locus_tag="BSU22270" /label="yppE gene" downshifts complement(2035046) /Source="Nicolas_upshifts" /id="D1169" /incds=0 /nref=158 /ntot=245 /MaxReadThrough="1.04225" /MaxDrop="5.78413" /score="-2.77698308" /energy="-10.3" /TU="NA" /idTUdmin="U1749" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2035396..2035415) /Source="Nicolas_upshift_promotors" /id="U1749" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2155 /SigmaFactorBS="acacaggtatgcgtttgagaaggtataccgcatcggCTGAAT ttgtgagtgaaaTTTGGTACGATAGGCATTGAggtgaaagatattgctatcacaaact t" /listShort="yppE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2035409) /Source="Nicolas_upshifts" /id="U1749" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2155 /SigmaFactorBS="acacaggtatgcgtttgagaaggtataccgcatcggCTGAAT ttgtgagtgaaaTTTGGTACGATAGGCATTGAggtgaaagatattgctatcacaaact t" /listShort="yppE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2035428..2035433) /Source="Nicolas_upshift_promotors" /id="U1749" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2155 /SigmaFactorBS="acacaggtatgcgtttgagaaggtataccgcatcggCTGAAT ttgtgagtgaaaTTTGGTACGATAGGCATTGAggtgaaagatattgctatcacaaact t" /listShort="yppE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2035430..2035675) /gene="yppD" /locus_tag="BSU_22280" /old_locus_tag="BSU22280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15687200; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative sporulation protein" /protein_id="NP_390110.1" /db_xref="EnsemblGenomes-Gn:BSU22280" /db_xref="EnsemblGenomes-Tr:CAB14145" /db_xref="InterPro:IPR020252" /db_xref="SubtiList:BG11445" /db_xref="UniProtKB/Swiss-Prot:P50832" /translation="MSGYVCKTDILRMLSDIEDELTRAEQSLNHSVNALEAEMRETEN DRLSVLEEEIIDLHICINELYQSPEHRYAFEKVYRIG*" /label="yppD CDS" gene complement(2035430..2035675) /gene="yppD" /locus_tag="BSU_22280" /old_locus_tag="BSU22280" /label="yppD gene" promotor_-10 complement(2035701..2035719) /Source="Nicolas_upshift_promotors" /id="U1750" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=446 /SigmaFactorBS="gcgatttgcttctagttttgtcatgagGAAGGAAAGagcctt gagagCAAAGAATGTTAACCGGGAgagacaaggaaagggaggtacacgaatgtccggt t" /listShort="yppD, yppE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2035706) /Source="Nicolas_upshifts" /id="U1750" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=446 /SigmaFactorBS="gcgatttgcttctagttttgtcatgagGAAGGAAAGagcctt gagagCAAAGAATGTTAACCGGGAgagacaaggaaagggaggtacacgaatgtccggt t" /listShort="yppD, yppE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2035731..2035739) /Source="Nicolas_upshift_promotors" /id="U1750" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=446 /SigmaFactorBS="gcgatttgcttctagttttgtcatgagGAAGGAAAGagcctt gagagCAAAGAATGTTAACCGGGAgagacaaggaaagggaggtacacgaatgtccggt t" /listShort="yppD, yppE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2035825..2035831 /Source="Nicolas_upshift_promotors" /id="U1751" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=860 /SigmaFactorBS="ctgaagttttcgacaaaaacacccgcaaaaatTGTATGAtcc tcctcattaatGCAAACGATACTtgtgaggaggtgccgtatgaaaacaagaccgaaaa a" /listShort="sspM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2035846..2035857 /Source="Nicolas_upshift_promotors" /id="U1751" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=860 /SigmaFactorBS="ctgaagttttcgacaaaaacacccgcaaaaatTGTATGAtcc tcctcattaatGCAAACGATACTtgtgaggaggtgccgtatgaaaacaagaccgaaaa a" /listShort="sspM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2035853 /Source="Nicolas_upshifts" /id="U1751" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=860 /SigmaFactorBS="ctgaagttttcgacaaaaacacccgcaaaaatTGTATGAtcc tcctcattaatGCAAACGATACTtgtgaggaggtgccgtatgaaaacaagaccgaaaa a" /listShort="sspM" /GFF_Attribute="listLong" /label="upshifts" CDS 2035874..2035978 /gene="sspM" /locus_tag="BSU_22290" /old_locus_tag="BSU22290" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10806362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10806362; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="YP_054585.1" /db_xref="EnsemblGenomes-Gn:BSU22290" /db_xref="EnsemblGenomes-Tr:CAE01459" /db_xref="GOA:Q7WY65" /db_xref="SubtiList:BG14177" /db_xref="UniProtKB/Swiss-Prot:Q7WY65" /translation="MKTRPKKAGQQKKTESKAIDSLDKKLGGPNRPST*" /label="sspM CDS" gene 2035874..2035978 /gene="sspM" /locus_tag="BSU_22290" /old_locus_tag="BSU22290" /label="sspM gene" downshifts 2035960 /Source="Nicolas_upshifts" /id="D1170" /incds=0 /nref=31 /ntot=49 /MaxReadThrough="1.6498" /MaxDrop="6.01285" /score="0.283992322" /energy="-8.5" /TU="NA" /idTUdmin="U1751" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2036003..2036965) /gene="yppC" /locus_tag="BSU_22300" /old_locus_tag="BSU22300" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390111.1" /db_xref="EnsemblGenomes-Gn:BSU22300" /db_xref="EnsemblGenomes-Tr:CAB14146" /db_xref="InterPro:IPR019658" /db_xref="SubtiList:BG10952" /db_xref="UniProtKB/Swiss-Prot:P39791" /translation="MNVQEQQAIRKLLSRIERQTKMKNADNISRTNAYKAFYDRHPEI KWSLLASFVSRNAGWSMTDLKGSLFQLGLRERQQKWFFLAYERANWLIFSDAYPQLLL YHWSKRVGKPLFHLLHVFGVSQFMSEEWTRFWHERNTERLMYALIINEQNTIQTPIIQ NPSFKKNVFDTIPFYLSDWFHFNTVIFPSSNGFFYGISVKRFSKAEERIRLGKQLSQL LFKPELFSSFYHFLHTVPHTGSRFDMEKMIGITKRTSPMLRTCYPELIHSLDGTKTDW FHGKIKKTFFRREELPKQIELTDWYLHKKRQLHALFAVEQWLKK*" /label="yppC CDS" gene complement(2036003..2036965) /gene="yppC" /locus_tag="BSU_22300" /old_locus_tag="BSU22300" /label="yppC gene" promotor_-35 2036133..2036142 /Source="Nicolas_upshift_promotors" /id="U1752" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1658 /SigmaFactorBS="aattcctcgcgcctaaagaacgttttctttatctttccaTGA AACCAATctgttttcgttCCGTCTAATGAGTGGAttaactcagggtagcatgtcctta g" /listShort="S843, S844, recU, ponA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2036154..2036169 /Source="Nicolas_upshift_promotors" /id="U1752" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1658 /SigmaFactorBS="aattcctcgcgcctaaagaacgttttctttatctttccaTGA AACCAATctgttttcgttCCGTCTAATGAGTGGAttaactcagggtagcatgtcctta g" /listShort="S843, S844, recU, ponA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2036154 /Source="Nicolas_upshifts" /id="U1752" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1658 /SigmaFactorBS="aattcctcgcgcctaaagaacgttttctttatctttccaTGA AACCAATctgttttcgttCCGTCTAATGAGTGGAttaactcagggtagcatgtcctta g" /listShort="S843, S844, recU, ponA" /GFF_Attribute="listLong" /label="upshifts" S_feature 2036158..2036493 /Source="Nicolas_S_feature" /locus_tag="new_2339954_2340289" /HighExp="T1.0H, T0.30H, T1.30H, H2O2, Paraq, LBGstat, T2.0H, T-0.40H, Salt, T2.30H" /AntisenseName="yppC" /AntisenseCor="-0.27690969451148201" /AntisenseRegPval="-5.4" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S843" promotor_-35 2036464..2036468 /Source="Nicolas_upshift_promotors" /id="U1753" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.965034965034965" /psig=1 /xcortree=2511 /SigmaFactorBS="acttaaataaaaaggaatcgtgtcaaaaaCATTCtttttaaa cgaaggaTTTTGTATAATAGGTGTTTGgatagtgttttgttcatttataatgagggca t" /listShort="S844, recU, ponA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2036484..2036503 /Source="Nicolas_upshift_promotors" /id="U1753" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.965034965034965" /psig=1 /xcortree=2511 /SigmaFactorBS="acttaaataaaaaggaatcgtgtcaaaaaCATTCtttttaaa cgaaggaTTTTGTATAATAGGTGTTTGgatagtgttttgttcatttataatgagggca t" /listShort="S844, recU, ponA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2036495..2037005 /Source="Nicolas_S_feature" /locus_tag="new_2340291_2340801" /HighExp="LBGstat, T1.0H, T1.30H, H2O2, T0.30H, Paraq, T2.0H, C30, G135, G180" /AntisenseName="yppC" /AntisenseCor="-0.312791370178301" /AntisenseRegPval="-6.8" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigWXY" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S844" upshifts 2036495 /Source="Nicolas_upshifts" /id="U1753" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.965034965034965" /psig=1 /xcortree=2511 /SigmaFactorBS="acttaaataaaaaggaatcgtgtcaaaaaCATTCtttttaaa cgaaggaTTTTGTATAATAGGTGTTTGgatagtgttttgttcatttataatgagggca t" /listShort="S844, recU, ponA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2036966..2037422) /Source="Nicolas_S_feature" /locus_tag="new_2340762_2341218_c" /HighExp="S8, S6, S7, S5, C30, G135, S4, BT, G180, Fru" /AntisenseName="recU" /AntisenseCor="-0.34780203121991599" /AntisenseRegPval="-8.3000000000000007" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S845" CDS 2037006..2037626 /gene="recU" /locus_tag="BSU_22310" /old_locus_tag="BSU22310" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:14701911, 15317759, 16020779, 16024744, 19433509, 19542287, 20735784, 21600217, 27903910" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14701911, 15317759, 16020779, 16024744, 19433509, 19542287, 20735784, 21600217, 27903910; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="Holliday junction resolvase" /protein_id="NP_390112.1" /db_xref="EnsemblGenomes-Gn:BSU22310" /db_xref="EnsemblGenomes-Tr:CAB14147" /db_xref="GOA:P39792" /db_xref="InterPro:IPR004612" /db_xref="InterPro:IPR011335" /db_xref="PDB:1RZN" /db_xref="PDB:1ZP7" /db_xref="PDB:5FDK" /db_xref="SubtiList:BG10953" /db_xref="UniProtKB/Swiss-Prot:P39792" /translation="MIRYPNGKTFQPKHSVSSQNSQKRAPSYSNRGMTLEDDLNETNK YYLTNQIAVIHKKPTPVQIVNVHYPKRSAAVIKEAYFKQSSTTDYNGIYKGRYIDFEA KETKNKTSFPLQNFHDHQIEHMKQVKAQDGICFVIISAFDQVYFLEADKLFYFWDRKE KNGRKSIRKDELEETAYPISLGYAPRIDYISIIEQLYFSPSSGAKG*" /label="recU CDS" gene 2037006..2037626 /gene="recU" /locus_tag="BSU_22310" /old_locus_tag="BSU22310" /label="recU gene" promotor_-10 complement(2037411..2037422) /Source="Nicolas_upshift_promotors" /id="U1754" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=893 /SigmaFactorBS="ttttctgtcccagaaataaaacagcttatcggcttccaaAAA ATAAacctggtcgaaagcGGATATAATAACaaaacaaataccgtcttgagcctttacc t" /listShort="S845" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2037422) /Source="Nicolas_upshifts" /id="U1754" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=893 /SigmaFactorBS="ttttctgtcccagaaataaaacagcttatcggcttccaaAAA ATAAacctggtcgaaagcGGATATAATAACaaaacaaataccgtcttgagcctttacc t" /listShort="S845" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2037437..2037443) /Source="Nicolas_upshift_promotors" /id="U1754" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=893 /SigmaFactorBS="ttttctgtcccagaaataaaacagcttatcggcttccaaAAA ATAAacctggtcgaaagcGGATATAATAACaaaacaaataccgtcttgagcctttacc t" /listShort="S845" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2037648..2040392 /gene="ponA" /locus_tag="BSU_22320" /old_locus_tag="BSU22320" /EC_number="2.4.1.129" /function="16.9: Replicate" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10322023, 10692371, 12562814, 15262952, 18266856, 25355936, 27852437" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10322023, 10692371, 12562814, 15262952, 18266856, 25355936, 27852437; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peptidoglycan glycosyltransferase (penicillin-binding proteins 1A and 1B)" /protein_id="NP_390113.1" /db_xref="EnsemblGenomes-Gn:BSU22320" /db_xref="EnsemblGenomes-Tr:CAB14148" /db_xref="GOA:P39793" /db_xref="InterPro:IPR001264" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR003961" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR023346" /db_xref="InterPro:IPR036116" /db_xref="InterPro:IPR036950" /db_xref="SubtiList:BG10954" /db_xref="UniProtKB/Swiss-Prot:P39793" /translation="MSDQFNSREARRKANSKSSPSPKKGKKRKKGGLFKKTLFTLLIL FVLGVVGGAVTFAVMVSDAPSLDESKLKTPYSSTIYDKNGKEIAEVGAEKRTYVSIDE IPDVVKEAFIATEDARFYEHHGIDPVRIGGALVANFKDGFGAEGGSTITQQVVKNSLL SHQKTLKRKVQEVWLSIQLERNYSKDEILEMYLNRIYFSPRAYGIGKAAEEFFGVTDL SKLTVEQAATLAGMPQSPTAYNPVKNPDKAEKRRNIVLSLMKKQGFISDSQYNKAKKV AVKDEGVVSQKEYEKASTNKYSAFVEEVMKEIDEKSDVDPSADGLKIYTTLDTKAQDK LDELMDGDTVGFTEGMQGGVTLLDTKNGEVRAIGAGRNQPVGGFNYATQTKAQPGSTI KPILDYGPVIENKKWSTYEQIDDSAYTYSNGKPIRDWDRKYLGPISMRYALAQSRNIP ALKAFQAVGKDTAVDFANGLGLGLTKDNVTEAYSIGGFGGNDGVSPLTMAGAYSAFGN NGTYNEPHFVKSIEFNDGTKLDLTPKSKSAMSDYTAFMITDMLKTAVKTGTGQLAQVP GVEVAGKTGTTNFDDNEVKRYNIASGGARDSWFVGYTPQYTAAVWTGMGENEAGKKSL SAEEQKVAKRIFAQLIADVDDGSGSFEKPDSVVEATVEKGSNPAKLAGPNTPSDKKLT EYFVKGTAPSTVSKTYEKEEKEETAKLSGLNVKYDKDNQSLTLSWNYDGDATFAVKQS VDGGSYSEIQNSSAKEAVISGVQPGSVYKFEVTAVSDDGKSTASTSYEVPKAEDDEDK KDQQQTDDEKQDDEKTQDDTQTDDSQKDDGQTDQDQTDDSTNDQDKKQDNTNTNPSDN NNQDQSNDNDNDNSNNQDTSDGDSNSGKNDSTGSDTNKNKTDTSNKTQTNSSSIEKTN *" /label="ponA CDS" gene 2037648..2040392 /gene="ponA" /locus_tag="BSU_22320" /old_locus_tag="BSU22320" /label="ponA gene" downshifts complement(2040062) /Source="Nicolas_upshifts" /id="D1171" /incds=1 /nref=1 /ntot=77 /MaxReadThrough="1.95969" /MaxDrop="2.87717" /score="24.9960782" /energy="-11.3" /TU="NA" /idTUdmin="U1755" /TUdmin=418 /isTUend="FALSE" /label="downshifts" downshifts 2040378 /Source="Nicolas_upshifts" /id="D1172" /incds=0 /nref=243 /ntot=302 /MaxReadThrough="1.61976" /MaxDrop="7.42523" /score="24.2831363" /energy="-14.6" /TU="U1753" /idTUdmin="U1752" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS complement(2040468..2040962) /gene="ypoC" /locus_tag="BSU_22330" /old_locus_tag="BSU22330" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390114.1" /db_xref="EnsemblGenomes-Gn:BSU22330" /db_xref="EnsemblGenomes-Tr:CAB14149" /db_xref="SubtiList:BG10955" /db_xref="UniProtKB/Swiss-Prot:P39789" /translation="MTQAKEVLASYEQYLRSLGQKSSSDMKKTLQTNPVYFDFCTELQ GDLPWEDSGKYVPLLFEVWDDIKASLLPVFQTRKSRCDQNEMLKGIVCLLASLHWTAG EPVKSLDWQELREKSYPAKPINWAERVEFILLKPTQYHCFIQLDELITEMKKHFYKYH AMNR*" /label="ypoC CDS" gene complement(2040468..2040962) /gene="ypoC" /locus_tag="BSU_22330" /old_locus_tag="BSU22330" /label="ypoC gene" downshifts complement(2040481) /Source="Nicolas_upshifts" /id="D1173" /incds=0 /nref=116 /ntot=222 /MaxReadThrough="2.50883" /MaxDrop="5.43593" /score="29.5358766" /energy="-11.6" /TU="NA" /idTUdmin="U1755" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2040959..2041618) /gene="nth" /locus_tag="BSU_22340" /old_locus_tag="BSU22340" /EC_number="4.2.99.18" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9808040, 11160880, 12682299, 21954439, 24914186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9808040, 11160880, 12682299, 21954439, 24914186; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endonuclease III, apurinic apyrimidic DNA lyase" /protein_id="NP_390115.1" /db_xref="EnsemblGenomes-Gn:BSU22340" /db_xref="EnsemblGenomes-Tr:CAB14150" /db_xref="GOA:P39788" /db_xref="InterPro:IPR000445" /db_xref="InterPro:IPR003265" /db_xref="InterPro:IPR003651" /db_xref="InterPro:IPR004035" /db_xref="InterPro:IPR004036" /db_xref="InterPro:IPR005759" /db_xref="InterPro:IPR011257" /db_xref="InterPro:IPR023170" /db_xref="SubtiList:BG10956" /db_xref="UniProtKB/Swiss-Prot:P39788" /translation="MLNLKQIEFCLDKIGDMFPHAECELVHSNPFELVVAVALSAQCT DALVNRVTKTLFQKYKRPEDYLAVPLEELQQDIKSIGLYRNKAKNIQKLSKMIIEDYG GEVPRDRDELVKLPGVGRKTANVVVSVAFGVPAIAVDTHVERVSKRLGICRWKDSVLE VEKTLMRKVPKEDWSVTHHRLIFFGRYHCKAQSPRCAECPLLSLCREGQKRDKKGLVK R*" /label="nth CDS" gene complement(2040959..2041618) /gene="nth" /locus_tag="BSU_22340" /old_locus_tag="BSU22340" /label="nth gene" CDS complement(2041637..2042335) /gene="dnaD" /locus_tag="BSU_22350" /old_locus_tag="BSU22350" /function="16.9: Replicate" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11222620, 12682299, 15556628, 15686560, 16002087, 16677303, 16855238, 17277452, 18206906, 21954439, 22821970, 23909787" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11222620, 12682299, 15556628, 15686560, 16002087, 16677303, 16855238, 17277452, 18206906, 21954439, 22821970, 23909787; Product type f: factor" /codon_start=1 /transl_table=11 /product="DNA-remodelling primosomal protein" /protein_id="NP_390116.1" /db_xref="EnsemblGenomes-Gn:BSU22350" /db_xref="EnsemblGenomes-Tr:CAB14151" /db_xref="GOA:P39787" /db_xref="InterPro:IPR006343" /db_xref="InterPro:IPR034829" /db_xref="PDB:2V79" /db_xref="SubtiList:BG10957" /db_xref="UniProtKB/Swiss-Prot:P39787" /translation="MKKQQFIDMQEQGTSTIPNLLLTHYKQLGLNETELILLLKIKMH LEKGSYFPTPNQLQEGMSISVEECTNRLRMFIQKGFLFIEECEDQNGIKFEKYSLQPL WGKLYEYIQLAQNQTQERKAEGEQKSLYTIFEEEFARPLSPLECETLAIWQDQDQHDA QLIKHALKEAVLSGKLSFRYIDRILFEWKKNGLKTVEQAKIHSQKFRRVQAKQNEPQK EYKRQVPFYNWLEQ*" /label="dnaD CDS" gene complement(2041637..2042335) /gene="dnaD" /locus_tag="BSU_22350" /old_locus_tag="BSU22350" /label="dnaD gene" S_feature complement(2042336..2042427) /Source="Nicolas_S_feature" /locus_tag="new_2346132_2346223_c" /HighExp="LoTm, G180, Cold, G135, LBGstat, G150, C30, Etha, Oxctl, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="0.999, 0.994, 0.85, 1" /TUlongSig="SigWXY, SigA, SigA" /TUlongPSig="1, 1, 0.995" /label="S846" CDS complement(2042428..2043720) /gene="asnS" /locus_tag="BSU_22360" /old_locus_tag="BSU22360" /EC_number="6.1.1.22" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 26804570; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="asparaginyl-tRNA synthetase" /protein_id="NP_390117.1" /db_xref="EnsemblGenomes-Gn:BSU22360" /db_xref="EnsemblGenomes-Tr:CAB14152" /db_xref="GOA:P39772" /db_xref="InterPro:IPR002312" /db_xref="InterPro:IPR004364" /db_xref="InterPro:IPR004365" /db_xref="InterPro:IPR004522" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR012340" /db_xref="SubtiList:BG10958" /db_xref="UniProtKB/Swiss-Prot:P39772" /translation="MKTTINQVYKHVGEEVTIGAWVANKRSSGKIAFLQLRDGTGFIQ GVVVKAEVEESIFQTAKSVTQETSLYIKGIVKEDERSPLGYELAVTDIEVIHEATDYP ITPKEHGTEFLMDHRHLWLRSKRQHAIMKIRNEIIRATYEFFNNEGFVKVDPPILTGS APEGTTELFATKYFDEDAYLSQSGQLYMEAAAMALGKVFSFGPTFRAEKSKTKRHLIE FWMIEPEMAFVEFEENLQVQENYVSFIVQSVLKNCKIELNTLGRDTSKLEQIKAPFPR ITYDEAIEFLKEKGFDDIEWGDDFGAPHETAIAEHYDKPVFITRYPTSLKPFYMQPAS DREDVVLCADLIAPEGYGEIIGGSERIHDMELLESRLKEHGLDSDAYKWYAELRKYGS VPHSGFGLGLERTVAWISGAPHVRETIPFPRLLNRLYP*" /label="asnS CDS" gene complement(2042428..2043720) /gene="asnS" /locus_tag="BSU_22360" /old_locus_tag="BSU22360" /label="asnS gene" S_feature complement(2043721..2043782) /Source="Nicolas_S_feature" /locus_tag="new_2347517_2347578_c" /HighExp="LBGexp, dia0, Lbexp, G150, G180, LPh, C30, Oxctl, LBGtran, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="0.999, 0.994, 0.85, 1" /TUlongSig="SigWXY, SigA, SigA" /TUlongPSig="1, 1, 0.995" /label="S847" promotor_-10 complement(2043782..2043801) /Source="Nicolas_upshift_promotors" /id="U1755" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.999000999001" /xcortree=2680 /SigmaFactorBS="gaaaagccgctttttatctGCATTGACccggttagttaagaG CGGGTATAATAAAGTGATGataaaagagttcgcggggcaatgagcttccgaatgtctt t" /listShort="S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2043782) /Source="Nicolas_upshifts" /id="U1755" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.999000999001" /xcortree=2680 /SigmaFactorBS="gaaaagccgctttttatctGCATTGACccggttagttaagaG CGGGTATAATAAAGTGATGataaaagagttcgcggggcaatgagcttccgaatgtctt t" /listShort="S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2043816..2043823) /Source="Nicolas_upshift_promotors" /id="U1755" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.663336663336663" /psig="0.999000999001" /xcortree=2680 /SigmaFactorBS="gaaaagccgctttttatctGCATTGACccggttagttaagaG CGGGTATAATAAAGTGATGataaaagagttcgcggggcaatgagcttccgaatgtctt t" /listShort="S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2043864..2045045) /gene="aspB" /locus_tag="BSU_22370" /old_locus_tag="BSU22370" /EC_number="2.6.1.1" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:418816, 12670965, 22740702" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 418816, 12670965, 22740702; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="anabolic oxaloacetate / glutamate aminotransferase" /protein_id="NP_390118.1" /db_xref="EnsemblGenomes-Gn:BSU22370" /db_xref="EnsemblGenomes-Tr:CAB14153" /db_xref="GOA:P53001" /db_xref="InterPro:IPR004838" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG11513" /db_xref="UniProtKB/Swiss-Prot:P53001" /translation="MKLAKRVSALTPSTTLAITAKAKELKAAGHDVIGLGAGEPDFNT PQHIIDAAVRSMNEGHTKYTPSGGLAELKNSIAEKFKRDQNIEYKPSQIIVCTGAKHA LYTLFQVILDEEDEVIIPTPYWVSYPEQVKLAGGKPVYVEGLEENHFKISPEQLKNAI TEKTKAIVINSPSNPTGVMYTEEELSALGEVCLEHDILIVSDEIYEKLTYGGKKHVSI AQLSDRLKEQTVIINGVSKSHSMTGWRIGYAAGSEDIIKAMTNLASHSTSNPTSIAQY GAIAAYNGPSEPLEEMREAFEHRLNTIYAKLIEIPGFSCVKPEGAFYLFPNAKEAAQS CGFKDVDEFVKALLEEEKVAIVPGSGFGSPENVRLSYATSLDLLEEAIERIKRFVEKH S*" /label="aspB CDS" gene complement(2043864..2045045) /gene="aspB" /locus_tag="BSU_22370" /old_locus_tag="BSU22370" /label="aspB gene" downshifts complement(2043868) /Source="Nicolas_upshifts" /id="D1174" /incds=0 /nref=48 /ntot=196 /MaxReadThrough="6.37268" /MaxDrop="4.0831" /score="5.04709675" /energy="-9.3" /TU="U1756,U1758,U1760,U1761,U1762" /idTUdmin="U1760" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" CDS complement(2045068..2045553) /gene="tseB" /locus_tag="BSU_22380" /old_locus_tag="BSU22380" /experiment="publication(s) with functional evidences, PMID:25954268" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25954268; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="suppressor of tetracyclin sensitivity of an ezrAmutant" /protein_id="NP_390119.1" /db_xref="EnsemblGenomes-Gn:BSU22380" /db_xref="EnsemblGenomes-Tr:CAB14154" /db_xref="GOA:P54396" /db_xref="InterPro:IPR025711" /db_xref="PDB:2GU3" /db_xref="SubtiList:BG11502" /db_xref="UniProtKB/Swiss-Prot:P54396" /translation="MRKKALIFTVIFGIIFLAVLLVSASIYKSAMAQKEEGHEAAAAE AKKETDLAHVDQVETFVGKEKYYVVKGTDKKGTALYVWVPADKKAKILSKEAKEGISE DKAAKIIKDEGLVSKQKEVHLAREGNVLLWEVTYLDKEGQYSLSYVDFTTGKILKNIT P*" /label="tseB CDS" gene complement(2045068..2045553) /gene="tseB" /locus_tag="BSU_22380" /old_locus_tag="BSU22380" /label="tseB gene" promotor_-10 complement(2045501..2045520) /Source="Nicolas_upshift_promotors" /id="U1756" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.47952047952048" /psig="0.994005994005994" /xcortree=2324 /SigmaFactorBS="ccatttatcgtacgtaggtgagaagatgagaaaaaaagCATT AATAtttaccgtcattTTTGGTATTATTTTTTTAGCagtacttcttgtctcggcaagc a" /listShort="ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2045518) /Source="Nicolas_upshifts" /id="U1756" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.47952047952048" /psig="0.994005994005994" /xcortree=2324 /SigmaFactorBS="ccatttatcgtacgtaggtgagaagatgagaaaaaaagCATT AATAtttaccgtcattTTTGGTATTATTTTTTTAGCagtacttcttgtctcggcaagc a" /listShort="ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2045533..2045540) /Source="Nicolas_upshift_promotors" /id="U1756" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.47952047952048" /psig="0.994005994005994" /xcortree=2324 /SigmaFactorBS="ccatttatcgtacgtaggtgagaagatgagaaaaaaagCATT AATAtttaccgtcattTTTGGTATTATTTTTTTAGCagtacttcttgtctcggcaagc a" /listShort="ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2045562..2045732) /gene="ypmA" /locus_tag="BSU_22390" /old_locus_tag="BSU22390" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390120.1" /db_xref="EnsemblGenomes-Gn:BSU22390" /db_xref="EnsemblGenomes-Tr:CAB14155" /db_xref="InterPro:IPR012190" /db_xref="SubtiList:BG11501" /db_xref="UniProtKB/Swiss-Prot:P54395" /translation="MESKIEILSTINVEHSDDLYKIVDTLNRTLKRDNLMFGLALDEE NKNQAVFTIYRT*" /label="ypmA CDS" gene complement(2045562..2045732) /gene="ypmA" /locus_tag="BSU_22390" /old_locus_tag="BSU22390" /label="ypmA gene" S_feature complement(2045733..2045804) /Source="Nicolas_S_feature" /locus_tag="new_2349529_2349600_c" /HighExp="H2O2, T0.30H, T0.0H, dia15, T-0.40H, T-1.10H, G135, T1.0H, G180, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.136042" /TUshortSig="SigA, SigWXY, SigA, SigA, SigA" /TUshortPSig="0.85, 1, 1, 1, 0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S848" promotor_-35 2045766..2045772 /Source="Nicolas_upshift_promotors" /id="U1757" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=823 /SigmaFactorBS="ttttcatcctccagtttgaacaaatattgttaGTCATACtcc atttcaggacaCGCCATACTAGTatcacagagcgggaaatccgcttttaaataaaaca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2045787..2045806) /Source="Nicolas_upshift_promotors" /id="U1758" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.646353646353646" /psig="0.85014985014985" /xcortree=1587 /SigmaFactorBS="aagcggcttttgcggtgtgggagtaggatggtgtttTATTTA AaagcggatttcccgcTCTGTGATACTAGTATGGCGtgtcctgaaatggagtatgact a" /listShort="S848, ypmA, ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 2045787..2045798 /Source="Nicolas_upshift_promotors" /id="U1757" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=823 /SigmaFactorBS="ttttcatcctccagtttgaacaaatattgttaGTCATACtcc atttcaggacaCGCCATACTAGTatcacagagcgggaaatccgcttttaaataaaaca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2045794..2045868 /Source="Nicolas_S_feature" /locus_tag="new_2349590_2349664" /HighExp="S8, S6, S5, S7, nit, BT, G/S, Pyr, C30, ferm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S849" upshifts 2045794 /Source="Nicolas_upshifts" /id="U1757" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=823 /SigmaFactorBS="ttttcatcctccagtttgaacaaatattgttaGTCATACtcc atttcaggacaCGCCATACTAGTatcacagagcgggaaatccgcttttaaataaaaca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2045804) /Source="Nicolas_upshifts" /id="U1758" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.646353646353646" /psig="0.85014985014985" /xcortree=1587 /SigmaFactorBS="aagcggcttttgcggtgtgggagtaggatggtgtttTATTTA AaagcggatttcccgcTCTGTGATACTAGTATGGCGtgtcctgaaatggagtatgact a" /listShort="S848, ypmA, ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2045806..2045874) /Source="Nicolas_S_feature" /locus_tag="new_2349602_2349670_c" /HighExp="T0.30H, T1.0H, T-0.40H, T1.30H, T0.0H, Salt, H2O2, T-1.10H, Oxctl, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY, SigA, SigA, SigA" /TUshortPSig="1, 1, 1, 0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S850" promotor_-35 complement(2045822..2045828) /Source="Nicolas_upshift_promotors" /id="U1758" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.646353646353646" /psig="0.85014985014985" /xcortree=1587 /SigmaFactorBS="aagcggcttttgcggtgtgggagtaggatggtgtttTATTTA AaagcggatttcccgcTCTGTGATACTAGTATGGCGtgtcctgaaatggagtatgact a" /listShort="S848, ypmA, ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2045838 /Source="Nicolas_upshifts" /id="D1175" /incds=0 /nref=8 /ntot=26 /MaxReadThrough="0.48859" /MaxDrop="6.02806" /score="18.4569945" /energy="-8.4" /TU="NA" /idTUdmin="U1757" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2045875..2048670) /gene="dinG" /locus_tag="BSU_22400" /old_locus_tag="BSU22400" /EC_number="3.6.1.-" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8385320, 12060778, 17416902, 21546913, 22166102, 28527403" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8385320, 12060778, 17416902, 21546913, 22166102, 28527403; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="damage inducible ATP-dependent 3'->5' nuclease" /protein_id="NP_390121.1" /db_xref="EnsemblGenomes-Gn:BSU22400" /db_xref="EnsemblGenomes-Tr:CAB14156" /db_xref="GOA:P54394" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR006054" /db_xref="InterPro:IPR006310" /db_xref="InterPro:IPR006555" /db_xref="InterPro:IPR006935" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR013520" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR014013" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG11515" /db_xref="UniProtKB/Swiss-Prot:P54394" /translation="MNKQRFVVIDVETTGNSPKKGDKIIQIAAVVIENGQITERFSKY INPNKSIPAFIEQLTGISNQMVENEQPFEAVAEEVFQLLDGAYFVAHNIHFDLGFVKY ELHKAGFQLPDCEVLDTVELSRIVFPGFEGYKLTELSEELQLRHDQPHRADSDAEVTG LIFLEILEKLRQLPYPTLKQLRRLSQHFISDLTHLLDMFINENRHTEIPGYTRFSSFS VREPEAIDVRINEDENFSFEIESWEAGNEKALSELMPGYEKRDGQMMMMREVADAFAN REHALIEAPPGIGKTIGYLIPAALFAKKSKKPVIISTYSTLLQQQILTKDLPIVQDLF PFPVTAAILKGQSHYLCLYKFEQVLHEEDDNYDAVLTKAQLLVWLTETNTGDVAELNL PSGGKLLWDRLAYDDDSYKRSRSEHVIGFYERAKQIAMRSDLVITNHSLLLTDEGSHK KRLPESGTFIIDEAHHFERAASEHLGKRATYIELHTKLSRIGTLKEQGLLKKMRQLFQ RNSLPVDSFFELEEWLQHVQAESDAFFSSVHSFVKRRKPKEDLNRLVFKVNKESQDKS WSILTDGAERLCSMLTHLQQLFEAQSSLMEKHLKGMKSKTVFLADEYQRSMKGLQHYC QTLQKLFFGSDDDEAVWIEIDAKGAKNAVAIYAQPLEPGELLADQFFARKNSVVLTSA TLTVEGSFQFMIERLGLSDFFPRTMRIESPFSYDERMQVMIPKEMKSIQDTGQPEFIQ DTARYIELMAKEKQPKILVLFTSHDMLKKVHQELKHNMSASGIQLLAQGITGGSPGKL MKTFKTSNQAILLGTNHFWEGVDFPGDELTTVMIVRLPFRSPDHPLHAAKCELARKKG KNPFQTVSLPEAVLTFRQGIGRLLRSAGDKGTIIILDRRIKTAGYGRLFLDALPTTSV SEMTDSELEAYVAGEKE*" /label="dinG CDS" gene complement(2045875..2048670) /gene="dinG" /locus_tag="BSU_22400" /old_locus_tag="BSU22400" /label="dinG gene" promotor_-35 2046343..2046347 /Source="Nicolas_upshift_promotors" /id="U1759" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.645354645354645" /psig="0.340659340659341" /xcortree=32 /SigmaFactorBS="ccgggacttccgcctgtaatcccttgtgccaagagctgaatg ccggaagcactcatgttATGCTtAAGCTcctggtgaacctttttcagcatatcatggg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2046344 /Source="Nicolas_upshifts" /id="U1759" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.645354645354645" /psig="0.340659340659341" /xcortree=32 /SigmaFactorBS="ccgggacttccgcctgtaatcccttgtgccaagagctgaatg ccggaagcactcatgttATGCTtAAGCTcctggtgaacctttttcagcatatcatggg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2046349..2046353 /Source="Nicolas_upshift_promotors" /id="U1759" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.645354645354645" /psig="0.340659340659341" /xcortree=32 /SigmaFactorBS="ccgggacttccgcctgtaatcccttgtgccaagagctgaatg ccggaagcactcatgttATGCTtAAGCTcctggtgaacctttttcagcatatcatggg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2047000..2047015) /Source="Nicolas_upshift_promotors" /id="U1760" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1683 /SigmaFactorBS="gctttctttagctctgtacattcttttgtcaaacgaaGAAAA CCTAAagaagacttaaaCCGTCTAGTGTTTAAGgtgaacaaagaaagccaggataaaa g" /listShort="S850, S848, ypmA, ypmB, aspB" /listLong="S847, asnS, S846, dnaD, nth, ypoC" /label="promotor_-10" upshifts complement(2047014) /Source="Nicolas_upshifts" /id="U1760" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1683 /SigmaFactorBS="gctttctttagctctgtacattcttttgtcaaacgaaGAAAA CCTAAagaagacttaaaCCGTCTAGTGTTTAAGgtgaacaaagaaagccaggataaaa g" /listShort="S850, S848, ypmA, ypmB, aspB" /listLong="S847, asnS, S846, dnaD, nth, ypoC" /label="upshifts" promotor_-35 complement(2047028..2047037) /Source="Nicolas_upshift_promotors" /id="U1760" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1683 /SigmaFactorBS="gctttctttagctctgtacattcttttgtcaaacgaaGAAAA CCTAAagaagacttaaaCCGTCTAGTGTTTAAGgtgaacaaagaaagccaggataaaa g" /listShort="S850, S848, ypmA, ypmB, aspB" /listLong="S847, asnS, S846, dnaD, nth, ypoC" /label="promotor_-35" S_feature complement(2048671..2048795) /Source="Nicolas_S_feature" /locus_tag="new_2352467_2352591_c" /HighExp="dia15, Diami, H2O2, Heat, LBGstat, C30, G180, G135, Oxctl, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S851" CDS complement(2048796..2049179) /gene="panD" /locus_tag="BSU_22410" /old_locus_tag="BSU22410" /EC_number="4.1.1.11" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9169598, 12600205, 15033515, 26762040" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9169598, 12600205, 15033515, 26762040; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aspartate 1-decarboxylase" /protein_id="NP_390122.1" /db_xref="EnsemblGenomes-Gn:BSU22410" /db_xref="EnsemblGenomes-Tr:CAB14157" /db_xref="GOA:P52999" /db_xref="InterPro:IPR003190" /db_xref="InterPro:IPR009010" /db_xref="SubtiList:BG11493" /db_xref="UniProtKB/Swiss-Prot:P52999" /translation="MYRTMMSGKLHRATVTEANLNYVGSITIDEDLIDAVGMLPNEKV QIVNNNNGARLETYIIPGKRGSGVICLNGAAARLVQEGDKVIIISYKMMSDQEAASHE PKVAVLNDQNKIEQMLGNEPARTIL*" /label="panD CDS" gene complement(2048796..2049179) /gene="panD" /locus_tag="BSU_22410" /old_locus_tag="BSU22410" /label="panD gene" CDS complement(2049181..2050041) /gene="panC" /locus_tag="BSU_22420" /old_locus_tag="BSU22420" /EC_number="6.3.2.1" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17175524, 7037743; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pantothenate synthetase" /protein_id="NP_390123.1" /db_xref="EnsemblGenomes-Gn:BSU22420" /db_xref="EnsemblGenomes-Tr:CAB14158" /db_xref="GOA:P52998" /db_xref="InterPro:IPR003721" /db_xref="InterPro:IPR004821" /db_xref="InterPro:IPR014729" /db_xref="SubtiList:BG11520" /db_xref="UniProtKB/Swiss-Prot:P52998" /translation="MRQITDISQLKEAIKQYHSEGKSIGFVPTMGFLHEGHLTLADKA RQENDAVIMSIFVNPAQFGPNEDFEAYPRDIERDAALAENAGVDILFTPDAHDMYPGE KNVTIHVERRTDVLCGRSREGHFDGVAIVLTKLFNLVKPTRAYFGLKDAQQVAVVDGL ISDFFMDIELVPVDTVREEDGLAKSSRNVYLTAEERKEAPKLYRALQTSAELVQAGER DPEAVIKAAKDIIETTSGTIDYVELYSYPELEPVNEIAGKMILAVAVAFSKARLIDNI IIDIREMERI*" /label="panC CDS" gene complement(2049181..2050041) /gene="panC" /locus_tag="BSU_22420" /old_locus_tag="BSU22420" /label="panC gene" CDS complement(2050043..2050876) /gene="panB" /locus_tag="BSU_22430" /old_locus_tag="BSU22430" /EC_number="2.1.2.11" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1844812, 8096212; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ketopantoate hydroxymethyltransferase" /protein_id="NP_390124.1" /db_xref="EnsemblGenomes-Gn:BSU22430" /db_xref="EnsemblGenomes-Tr:CAB14159" /db_xref="GOA:P52996" /db_xref="InterPro:IPR003700" /db_xref="InterPro:IPR015813" /db_xref="SubtiList:BG11519" /db_xref="UniProtKB/Swiss-Prot:P52996" /translation="MKTKLDFLKMKESEEPIVMLTAYDYPAAKLAEQAGVDMILVGDS LGMVVLGLDSTVGVTVADMIHHTKAVKRGAPNTFIVTDMPFMSYHLSKEDTLKNAAAI VQESGADALKLEGGEGVFESIRALTLGGIPVVSHLGLTPQSVGVLGGYKVQGKDEQSA KKLIEDSIKCEEAGAMMLVLECVPAELTAKIAETLSIPVIGIGAGVKADGQVLVYHDI IGHGVERTPKFVKQYTRIDETIETAISGYVQDVRHRAFPEQKHSFQMNQTVLDGLYGG K*" /label="panB CDS" gene complement(2050043..2050876) /gene="panB" /locus_tag="BSU_22430" /old_locus_tag="BSU22430" /label="panB gene" S_feature complement(2050877..2051084) /Source="Nicolas_S_feature" /locus_tag="new_2354673_2354880_c" /HighExp="LBGstat, dia15, Diami, H2O2, MG 15, Heat, Oxctl, MG 25, MG 10, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S852" promotor_-10 complement(2051079..2051098) /Source="Nicolas_upshift_promotors" /id="U1761" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=2662 /SigmaFactorBS="ctgccgatatcgaattgggctaatgTGTTGgtacaagcccgt tgatTTTGGTATACTTCCATTGGGcagtatcgcctgcgaactgcacctattattaaaa t" /listShort="S852, panB, panC, panD, S851, dinG, S850, S848, ypmA, ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2051084) /Source="Nicolas_upshifts" /id="U1761" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=2662 /SigmaFactorBS="ctgccgatatcgaattgggctaatgTGTTGgtacaagcccgt tgatTTTGGTATACTTCCATTGGGcagtatcgcctgcgaactgcacctattattaaaa t" /listShort="S852, panB, panC, panD, S851, dinG, S850, S848, ypmA, ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2051115..2051119) /Source="Nicolas_upshift_promotors" /id="U1761" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=2662 /SigmaFactorBS="ctgccgatatcgaattgggctaatgTGTTGgtacaagcccgt tgatTTTGGTATACTTCCATTGGGcagtatcgcctgcgaactgcacctattattaaaa t" /listShort="S852, panB, panC, panD, S851, dinG, S850, S848, ypmA, ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2051122..2052099) /gene="birA" /locus_tag="BSU_22440" /old_locus_tag="BSU22440" /EC_number="6.3.4.15" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12368242, 15459338, 28466579" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12368242, 15459338, 28466579; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="biotin acetyl-CoA-carboxylase ligase and biotin regulon repressor (BirA-biotinoyl-5'-AMP)" /protein_id="NP_390125.1" /db_xref="EnsemblGenomes-Gn:BSU22440" /db_xref="EnsemblGenomes-Tr:CAB14160" /db_xref="GOA:P0CI75" /db_xref="InterPro:IPR003142" /db_xref="InterPro:IPR004143" /db_xref="InterPro:IPR004408" /db_xref="InterPro:IPR004409" /db_xref="InterPro:IPR008988" /db_xref="InterPro:IPR013196" /db_xref="InterPro:IPR030855" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11206" /db_xref="UniProtKB/Swiss-Prot:P0CI75" /translation="MRSTLRKDLIELFSQAGNEFISGQKISDALGCSRTAVWKHIEEL RKEGYEVEAVRRKGYRLIKKPGKLSESEIRFGLKTEVMGQHLIYHDVLSSTQKTAHEL ANNNAPEGTLVVADKQTAGRGRMSRVWHSQEGNGVWMSLILRPDIPLQKTPQLTLLAA VAVVQGIEEAAGIQTDIKWPNDILINGKKTVGILTEMQAEEDRVRSVIIGIGINVNQQ PNDFPDELKDIATSLSQAAGEKIDRAGVIQHILLCFEKRYRDYMTHGFTPIKLLWESY ALGIGTNMRARTLNGTFYGKALGIDDEGVLLLETNEGIKKIYSADIELG*" /label="birA CDS" gene complement(2051122..2052099) /gene="birA" /locus_tag="BSU_22440" /old_locus_tag="BSU22440" /label="birA gene" CDS complement(2052084..2053277) /gene="cca" /locus_tag="BSU_22450" /old_locus_tag="BSU22450" /EC_number="2.7.7.72" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9829937, 16109934, 20360175, 22940585" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9829937, 16109934, 20360175, 22940585; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA nucleotidyltransferase" /protein_id="NP_390126.1" /db_xref="EnsemblGenomes-Gn:BSU22450" /db_xref="EnsemblGenomes-Tr:CAB14161" /db_xref="GOA:P42977" /db_xref="InterPro:IPR002646" /db_xref="InterPro:IPR023068" /db_xref="InterPro:IPR032810" /db_xref="InterPro:IPR032828" /db_xref="SubtiList:BG11208" /db_xref="UniProtKB/Swiss-Prot:P42977" /translation="MEKVFIKALPVLRILIEAGHQAYFVGGAVRDSYMKRTIGDVDIA TDAAPDQVERLFQRTVDVGKEHGTIIVLWEDETYEVTTFRTESDYVDFRRPSEVQFIS SLEEDLKRRDLTINAMAMTADGKVLDYFGGKKDIDQKVIRTVGKPEDRFQEDALRMLR AVRFMSQLGFTLSPETEEAIAKEKSLLSHVSVERKTIEFEKLLQGRASRQALQTLIQT RLYEELPGFYHKRENLISTSEFPFFSLTSREELWAALLINLGIVLKDAPLFLKAWKLP GKVIKEAIHIADTFGQSLDAMTMYRAGKKALLSAAKISQLRQNEKLDEKKLKDIQYAY QNLPIKSLKDLDITGKDLLALRNRPAGKWVSEELQWIEQAVVTGKLSNQKKHIEEWLK TCGQH*" /label="cca CDS" gene complement(2052084..2053277) /gene="cca" /locus_tag="BSU_22450" /old_locus_tag="BSU22450" /label="cca gene" CDS complement(2053282..2054415) /gene="bshA" /locus_tag="BSU_22460" /old_locus_tag="BSU22460" /EC_number="2.4.1.-" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16751541, 20308541, 22569254, 27454321, 28301954" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16751541, 20308541, 22569254, 27454321, 28301954; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetyl-alpha-D-glucosaminyl L-malate synthase;malate glycosyltransferase for bacillithiol synthesis" /protein_id="NP_390127.1" /db_xref="EnsemblGenomes-Gn:BSU22460" /db_xref="EnsemblGenomes-Tr:CAB14162" /db_xref="GOA:P42982" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR023881" /db_xref="InterPro:IPR028098" /db_xref="PDB:5D00" /db_xref="PDB:5D01" /db_xref="SubtiList:BG11213" /db_xref="UniProtKB/Swiss-Prot:P42982" /translation="MRKLKIGITCYPSVGGSGIIATELGKQLAEKGHEIHFITSSIPF RLNTYHPNIHFHEVEVNQYAVFKYPPYDLTLASKIAEVAERENLDIIHAHYALPHAVC AYLAKQMLKRNIGIVTTLHGTDITVLGYDPSLKDLIRFAIESSDRVTAVSSALAAETY DLIKPEKKIETIYNFIDERVYLKKNTAAIKEKHGILPDEKVVIHVSNFRKVKRVQDVI RVFRNIAGKTKAKLLLVGDGPEKSTACELIRKYGLEDQVLMLGNQDRVEDLYSISDLK LLLSEKESFGLVLLEAMACGVPCIGTNIGGIPEVIKNNVSGFLVDVGDVTAATARAMS ILEDEQLSNRFTKAAIEMLENEFSSKKIVSQYEQIYADLAEPE*" /label="bshA CDS" gene complement(2053282..2054415) /gene="bshA" /locus_tag="BSU_22460" /old_locus_tag="BSU22460" /label="bshA gene" CDS complement(2054412..2055122) /gene="bshBA" /locus_tag="BSU_22470" /old_locus_tag="BSU22470" /EC_number="3.5.1.-" /function="4.10: Glutathione and analogs" /experiment="publication(s) with functional evidences, PMID:11004195, 20308541, 23894131, 28117687" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11004195, 20308541, 23894131, 28117687; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetyl-alpha-D-glucosaminyl L-malate deacetylase 1; malate N-acetylglucosamine N-acetyl hydrolase" /protein_id="NP_390128.2" /db_xref="EnsemblGenomes-Gn:BSU22470" /db_xref="EnsemblGenomes-Tr:CAB14163" /db_xref="GOA:P42981" /db_xref="InterPro:IPR003737" /db_xref="InterPro:IPR023842" /db_xref="InterPro:IPR024078" /db_xref="SubtiList:BG11212" /db_xref="UniProtKB/Swiss-Prot:P42981" /translation="MYNADVLAFGAHSDDVEIGMGGTIAKFVKQEKKVMICDLTEAEL SSNGTVSLRKEEAAEAARILGADKRIQLTLPDRGLIMSDQAIRSIVTVIRICRPKAVF MPYKKDRHPDHGNAAALVEEAIFSAGIHKYKDEKSLPAHKVSKVYYYMINGFHQPDFV IDISDTIEAKKQSLNAYKSQFIPSKDSVSTPLTNGYIEIVEAREKLYGKEAGVEYAEG FFSKRMLMLDHDVLGGEQ*" /label="bshBA CDS" gene complement(2054412..2055122) /gene="bshBA" /locus_tag="BSU_22470" /old_locus_tag="BSU22470" /label="bshBA gene" CDS complement(2055115..2055528) /gene="mgsA" /locus_tag="BSU_22480" /old_locus_tag="BSU22480" /EC_number="4.2.3.3" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9489667, 10368300, 10715115, 11423008, 15489434, 21992469, 23894131, 28807600" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9489667, 10368300, 10715115, 11423008, 15489434, 21992469, 23894131, 28807600; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylglyoxal synthase" /protein_id="NP_390129.1" /db_xref="EnsemblGenomes-Gn:BSU22480" /db_xref="EnsemblGenomes-Tr:CAB14164" /db_xref="GOA:P42980" /db_xref="InterPro:IPR004363" /db_xref="InterPro:IPR011607" /db_xref="InterPro:IPR018148" /db_xref="InterPro:IPR036914" /db_xref="SubtiList:BG11211" /db_xref="UniProtKB/Swiss-Prot:P42980" /translation="MKIALIAHDKKKQDMVQFTTAYRDILKNHDLYATGTTGLKIHEA TGLQIERFQSGPLGGDQQIGALIAANALDLVIFLRDPLTAQPHEPDVSALIRLCDVYS IPLATNMGTAEILVRTLDEGVFEFRDLLRGEEPNV*" /label="mgsA CDS" gene complement(2055115..2055528) /gene="mgsA" /locus_tag="BSU_22480" /old_locus_tag="BSU22480" /label="mgsA gene" CDS complement(2055544..2056347) /gene="dapB" /locus_tag="BSU_22490" /old_locus_tag="BSU22490" /EC_number="1.17.1.8" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 6422596, 9398235, 12682299, 20503968; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="(4S)-4-hydroxy-2,3,4, 5-tetrahydro-(2S)-dipicolinic acid (HTPA) dehydratase reductase" /protein_id="NP_390130.1" /db_xref="EnsemblGenomes-Gn:BSU22490" /db_xref="EnsemblGenomes-Tr:CAB14165" /db_xref="GOA:P42976" /db_xref="InterPro:IPR000846" /db_xref="InterPro:IPR022663" /db_xref="InterPro:IPR022664" /db_xref="InterPro:IPR023940" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11207" /db_xref="UniProtKB/Swiss-Prot:P42976" /translation="MSNETIKLVIAGPRGRMGQEAVKLAERTPHFDLVGAIDHTYDQQ KLSDVMPVESDAFIYTDIHACFTETQPDVLIDLTTPEIGKVHTKIALEHGVRPVVGTT GFSEADLKELTSLTEEKGIGAIIAPNFALGAILMMKFSKMAANYFEDVEIIELHHDQK LDAPSGTALKTAEMISEVRKEKQQGHPDEKEILPGARGAEQNGIRLHSVRLPGLIAHQ EVMFGMDGQTLQIRHDSYNRASFMSGVKLSVEQVMKIDQLVYGLENIID*" /label="dapB CDS" gene complement(2055544..2056347) /gene="dapB" /locus_tag="BSU_22490" /old_locus_tag="BSU22490" /label="dapB gene" CDS complement(2056359..2056694) /gene="ypjD" /locus_tag="BSU_22500" /old_locus_tag="BSU22500" /function="16.3: Control" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 16390452, 20529853, 20944217, 21733847, 24339782, 26920050, 28117687; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="oxidized nucleotide pyrophosphohydrolase" /protein_id="NP_390131.1" /db_xref="EnsemblGenomes-Gn:BSU22500" /db_xref="EnsemblGenomes-Tr:CAB14166" /db_xref="InterPro:IPR004518" /db_xref="InterPro:IPR012359" /db_xref="PDB:2GTA" /db_xref="SubtiList:BG11210" /db_xref="UniProtKB/Swiss-Prot:P42979" /translation="MSDKTMKDIQAEVDRYIGQFKEGYFSPLAMMARLTEELGELARE VNHRYGEKPKKATEDDKSMEEEIGDVLFVLVCLANSLDISLEEAHDRVMHKFNTRDKD RWTRKEEGK*" /label="ypjD CDS" gene complement(2056359..2056694) /gene="ypjD" /locus_tag="BSU_22500" /old_locus_tag="BSU22500" /label="ypjD gene" promotor_-10 complement(2056714..2056733) /Source="Nicolas_upshift_promotors" /id="U1762" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.632367632367632" /psig=1 /xcortree=2567 /SigmaFactorBS="atgaaaaagaaaacagcaaacgtgcttaaaCATTTGTCaaac gtatctgaaTTAGCTAACATGTAAGAGGAtgataggaggtttcgttcagtgagtgata a" /listShort="ypjD, dapB, mgsA, ypjG, ypjH, cca, birA, S852, panB, panC, panD, S851, dinG, S850, S848, ypmA, ypmB, aspB" /listLong="S847, asnS, S846, dnaD, nth, ypoC" /label="promotor_-10" upshifts complement(2056724) /Source="Nicolas_upshifts" /id="U1762" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.632367632367632" /psig=1 /xcortree=2567 /SigmaFactorBS="atgaaaaagaaaacagcaaacgtgcttaaaCATTTGTCaaac gtatctgaaTTAGCTAACATGTAAGAGGAtgataggaggtttcgttcagtgagtgata a" /listShort="ypjD, dapB, mgsA, ypjG, ypjH, cca, birA, S852, panB, panC, panD, S851, dinG, S850, S848, ypmA, ypmB, aspB" /listLong="S847, asnS, S846, dnaD, nth, ypoC" /label="upshifts" promotor_-35 complement(2056747..2056754) /Source="Nicolas_upshift_promotors" /id="U1762" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.632367632367632" /psig=1 /xcortree=2567 /SigmaFactorBS="atgaaaaagaaaacagcaaacgtgcttaaaCATTTGTCaaac gtatctgaaTTAGCTAACATGTAAGAGGAtgataggaggtttcgttcagtgagtgata a" /listShort="ypjD, dapB, mgsA, ypjG, ypjH, cca, birA, S852, panB, panC, panD, S851, dinG, S850, S848, ypmA, ypmB, aspB" /listLong="S847, asnS, S846, dnaD, nth, ypoC" /label="promotor_-35" promotor_-35 2056763..2056770 /Source="Nicolas_upshift_promotors" /id="U1763" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=2405 /SigmaFactorBS="ctaattcagatacgtttgacaaatgtttaagcaCGTTTGCTg ttttctttttcaTCCACTATAATATAAACGCTatctaatggaaggaaaaggggttttg t" /listShort="ypjC" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(2056779..2056798) /Source="Nicolas_upshift_promotors" /id="U1764" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.415584415584416" /psig="0.995004995004995" /xcortree=2307 /SigmaFactorBS="tttttaatctaatttctccaagcatcacacaaaacccctttt ccttccattagatagcgtTTATATTATAGTGGATGAAAaagaaaacagcaaacgtgct t" /listShort="ypjD, dapB, mgsA, ypjG, ypjH, cca, birA, S852, panB, panC, panD, S851, dinG, S850, S848, ypmA" /listLong="ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 2056784..2056803 /Source="Nicolas_upshift_promotors" /id="U1763" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=2405 /SigmaFactorBS="ctaattcagatacgtttgacaaatgtttaagcaCGTTTGCTg ttttctttttcaTCCACTATAATATAAACGCTatctaatggaaggaaaaggggttttg t" /listShort="ypjC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2056790 /Source="Nicolas_upshifts" /id="U1763" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=2405 /SigmaFactorBS="ctaattcagatacgtttgacaaatgtttaagcaCGTTTGCTg ttttctttttcaTCCACTATAATATAAACGCTatctaatggaaggaaaaggggttttg t" /listShort="ypjC" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2056798) /Source="Nicolas_upshifts" /id="U1764" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.415584415584416" /psig="0.995004995004995" /xcortree=2307 /SigmaFactorBS="tttttaatctaatttctccaagcatcacacaaaacccctttt ccttccattagatagcgtTTATATTATAGTGGATGAAAaagaaaacagcaaacgtgct t" /listShort="ypjD, dapB, mgsA, ypjG, ypjH, cca, birA, S852, panB, panC, panD, S851, dinG, S850, S848, ypmA" /listLong="ypmB, aspB, S847, asnS, S846, dnaD, nth, ypoC" /label="upshifts" CDS 2056834..2057706 /gene="ypjC" /locus_tag="BSU_22510" /old_locus_tag="BSU22510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390132.2" /db_xref="EnsemblGenomes-Gn:BSU22510" /db_xref="EnsemblGenomes-Tr:CAB14167" /db_xref="GOA:P42978" /db_xref="InterPro:IPR003740" /db_xref="InterPro:IPR019264" /db_xref="SubtiList:BG11209" /db_xref="UniProtKB/Swiss-Prot:P42978" /translation="MLGEIRLKNIFFILIGAAIFSFGLVHFNMQNNLAEGGFTGITLL LYALFHISPSISNLVLNIPIFFIGWRLLGRTMFVYTLVGTVALSLFLSIFQRYEIHMP LQHDLALAALFAGVFIGAGLGIIFKFGGTTGGVDIIARLVNKYFGIPMGRTMFAFDAC VIILSLLTYLSYKEAMYTLVAVFVAARLIDFIQEGGYAAKGATIISSKNDLIQKKILE EMERGVTILKGQGSYTKEDIDVLYCVVPKNELVMLKSVINSIDPHAFVAVSDVHDVLG EGFTLDENKNPLPR*" /label="ypjC CDS" gene 2056834..2057706 /gene="ypjC" /locus_tag="BSU_22510" /old_locus_tag="BSU22510" /label="ypjC gene" CDS complement(2057748..2058542) /gene="ypjB" /locus_tag="BSU_22520" /old_locus_tag="BSU22520" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12662922" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12662922; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="sporulation septum-associated protein" /protein_id="NP_390133.1" /db_xref="EnsemblGenomes-Gn:BSU22520" /db_xref="EnsemblGenomes-Tr:CAB14168" /db_xref="GOA:P54393" /db_xref="InterPro:IPR014231" /db_xref="SubtiList:BG11500" /db_xref="UniProtKB/Swiss-Prot:P54393" /translation="MKRKLTICLLIALIFYNGNAKAAERGSLEELNDLSDTVFQMTRQ AKYEEALQVLEYFEKTLKSAEKKQQDPMLTGAQIRQITLGYNDMVRSLKQADTSDTQK LRAAAQFRMLMDAVDNRSDPLWGSLEKPIMEAFTELKRDVQKNGSTSFHEKWNEFISL YDLIYPSLTIDVSEDQLETVGKHIDVIEQEEFQQMTESTKLERLSLLQHDLKNVFDRV EEDDADPSLLWVIITTGSIIITALTYVGYRKYKAEKNKLKKRDYPK*" /label="ypjB CDS" gene complement(2057748..2058542) /gene="ypjB" /locus_tag="BSU_22520" /old_locus_tag="BSU22520" /label="ypjB gene" downshifts complement(2057773) /Source="Nicolas_upshifts" /id="D1176" /incds=0 /nref=4 /ntot=106 /MaxReadThrough="1.96946" /MaxDrop="3.51024" /score="34.9661402" /energy="-11.3" /TU="NA" /idTUdmin="U1765" /TUdmin=198 /isTUend="FALSE" /label="downshifts" S_feature complement(2058543..2058610) /Source="Nicolas_S_feature" /locus_tag="new_2362339_2362406_c" /HighExp="LBGstat, C30, S0, LoTm, G180, G135, G150, Oxctl, Paraq, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.866" /TUlongSig="SigH, SigA" /TUlongPSig="1, 0.999" /label="S853" CDS complement(2058611..2059168) /gene="ypjA" /locus_tag="BSU_22530" /old_locus_tag="BSU22530" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406; Product type m:membrane component" /codon_start=1 /transl_table=11 /product="conserved integral inner membrane protein of unknown function" /protein_id="NP_390134.1" /db_xref="EnsemblGenomes-Gn:BSU22530" /db_xref="EnsemblGenomes-Tr:CAB14169" /db_xref="GOA:P54392" /db_xref="InterPro:IPR009845" /db_xref="SubtiList:BG11499" /db_xref="UniProtKB/Swiss-Prot:P54392" /translation="MLILVLAINFLGTVYGYYWYLPQLLETPARFLIFVPDSPTATFF FLFVLLAFLMKRNAPLLEALALVTLVKYGLWAVAMNFLVLAVTGDLPWEGYMLIASHF AMAVQGVLYSPYFRFSFWHLAIAAVWTLHNDVIDYLFDMMPQYSMLSDYMTEIGYGTF WLSIFSIALAYFLVVSKKQTKLELM*" /label="ypjA CDS" gene complement(2058611..2059168) /gene="ypjA" /locus_tag="BSU_22530" /old_locus_tag="BSU22530" /label="ypjA gene" S_feature complement(2059169..2059248) /Source="Nicolas_S_feature" /locus_tag="new_2362965_2363044_c" /HighExp="C30, UNK1, G135, BMM, G150, G180, Oxctl, LoTm, Paraq, S0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.866" /TUlongSig="SigH, SigA" /TUlongPSig="1, 0.999" /label="S854" downshifts complement(2059293) /Source="Nicolas_upshifts" /id="D1177" /incds=0 /nref=131 /ntot=215 /MaxReadThrough="3.97061" /MaxDrop="6.41485" /score="13.3880841" /energy="-8" /TU="U1765" /idTUdmin="U1767" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(2059315..2060082) /gene="qcrC" /locus_tag="BSU_22540" /old_locus_tag="BSU22540" /function="16.10: Respire" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7592464, 8647852, 12446663, 12615356, 19114526; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="menaquinol:cytochrome c oxidoreductase (cytochrome cc subunit)" /protein_id="NP_390135.1" /db_xref="EnsemblGenomes-Gn:BSU22540" /db_xref="EnsemblGenomes-Tr:CAB14170" /db_xref="GOA:P46913" /db_xref="InterPro:IPR005798" /db_xref="InterPro:IPR009056" /db_xref="InterPro:IPR012049" /db_xref="InterPro:IPR027387" /db_xref="InterPro:IPR036150" /db_xref="InterPro:IPR036909" /db_xref="SubtiList:BG11327" /db_xref="UniProtKB/Swiss-Prot:P46913" /translation="MHRGKGMKFVGDSRIPAEKKPNIPKDYSEYPGKTEAFWPNFLLK EWMVGAVFLIGFLVLTIVHQPPLERMADPTDTGYIPLPDWYFLFLYQLLKYEYAAGSF TVVGAMIMPGLAFGALLLAPFLDRGTERRPWKRPVAVGMMLLAISAAVFLTWQSVATH DWAKAEEQGKITKEADIDTNAEGYKVFKEQGCISCHGDNLQGGAAGPSLVDSGLKPDE IKKIAVEGKGKMPAGVFKGNDKQLEELAKFISETTAK*" /label="qcrC CDS" gene complement(2059315..2060082) /gene="qcrC" /locus_tag="BSU_22540" /old_locus_tag="BSU22540" /label="qcrC gene" CDS complement(2060117..2060791) /gene="qcrB" /locus_tag="BSU_22550" /old_locus_tag="BSU22550" /function="16.10: Respire" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7592464, 8647852, 12446663, 12615356, 15849754, 16850406; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="menaquinol:cytochrome c oxidoreductase (cytochrome b subunit)" /protein_id="NP_390136.1" /db_xref="EnsemblGenomes-Gn:BSU22550" /db_xref="EnsemblGenomes-Tr:CAB14171" /db_xref="GOA:P46912" /db_xref="InterPro:IPR005797" /db_xref="InterPro:IPR016174" /db_xref="InterPro:IPR023530" /db_xref="InterPro:IPR027387" /db_xref="SubtiList:BG11326" /db_xref="UniProtKB/Swiss-Prot:P46912" /translation="MLNKIYDWVDERLDITPMWRDIADHEVPEHVNPAHHFSAFVYCF GGLTFFVTVIQVLSGMFLTMYYVPDIKNAWESVYYLQNEVAFGQIVRGMHHWGASLVI VMMFLHTLRVFFQGAYKKPRELNWIVGVLIFFVMLGLGFTGYLLPWDMKALFATKVGL QIAEATPLIGTQVKTLLAGHPDIVGAQTLTRFFAIHVFFLPAALFGLMAAHFIMIRKQ GISGPL*" /label="qcrB CDS" gene complement(2060117..2060791) /gene="qcrB" /locus_tag="BSU_22550" /old_locus_tag="BSU22550" /label="qcrB gene" CDS complement(2060793..2061296) /gene="qcrA" /locus_tag="BSU_22560" /old_locus_tag="BSU22560" /EC_number="1.10.2.-" /function="16.10: Respire" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7592464, 8647852, 12446663, 12615356, 24652282, 27503613; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="menaquinol:cytochrome c oxidoreductase (iron-sulfur subunit)" /protein_id="NP_390137.1" /db_xref="EnsemblGenomes-Gn:BSU22560" /db_xref="EnsemblGenomes-Tr:CAB14172" /db_xref="GOA:P46911" /db_xref="InterPro:IPR006311" /db_xref="InterPro:IPR014349" /db_xref="InterPro:IPR014909" /db_xref="InterPro:IPR017941" /db_xref="InterPro:IPR036922" /db_xref="SubtiList:BG11325" /db_xref="UniProtKB/Swiss-Prot:P46911" /translation="MGGKHDISRRQFLNYTLTGVGGFMAASMLMPMVRFALDPVLKST GKQDMVQVVSVDELTKEPQRFDFKINQVDAWYESEESRSAWVFKNGDEIVALSPICKH LGCTVNWNSDPKNPNKFFCPCHYGLYEKDGTNVPGTPPLAPLDHYEQEVKDGFLYLGK AKPKGEG*" /label="qcrA CDS" gene complement(2060793..2061296) /gene="qcrA" /locus_tag="BSU_22560" /old_locus_tag="BSU22560" /label="qcrA gene" downshifts 2061305 /Source="Nicolas_upshifts" /id="D1178" /incds=0 /nref=1 /ntot=80 /MaxReadThrough="1.24169" /MaxDrop="3.42621" /score="0.352684802" /energy="-11.5" /TU="NA" /idTUdmin="U1763" /TUdmin=3608 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2061360..2061379) /Source="Nicolas_upshift_promotors" /id="U1765" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.595404595404595" /psig="0.866133866133866" /xcortree=512 /SigmaFactorBS="ataaacaatattttggctaTATTGACCttgctgagagattcA TATATTATGAGGGTGTCTAgagttattgcaatattttctattttagtcagtttgcagg g" /listShort="qcrA, qcrB, qcrC, S854, ypjA, S853, ypjB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2061360) /Source="Nicolas_upshifts" /id="U1765" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.595404595404595" /psig="0.866133866133866" /xcortree=512 /SigmaFactorBS="ataaacaatattttggctaTATTGACCttgctgagagattcA TATATTATGAGGGTGTCTAgagttattgcaatattttctattttagtcagtttgcagg g" /listShort="qcrA, qcrB, qcrC, S854, ypjA, S853, ypjB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2061394..2061401) /Source="Nicolas_upshift_promotors" /id="U1765" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.595404595404595" /psig="0.866133866133866" /xcortree=512 /SigmaFactorBS="ataaacaatattttggctaTATTGACCttgctgagagattcA TATATTATGAGGGTGTCTAgagttattgcaatattttctattttagtcagtttgcagg g" /listShort="qcrA, qcrB, qcrC, S854, ypjA, S853, ypjB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2061439..2061885) /gene="ypiF" /locus_tag="BSU_22570" /old_locus_tag="BSU22570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15743949" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390138.1" /db_xref="EnsemblGenomes-Gn:BSU22570" /db_xref="EnsemblGenomes-Tr:CAB14173" /db_xref="InterPro:IPR019615" /db_xref="SubtiList:BG11498" /db_xref="UniProtKB/Swiss-Prot:P54391" /translation="MRWRITDAKDYLQAKDYIDTAVIPLINIRVNNHFKMAAEKGEFT QLLSEELERQLKGRVYLLPPYTYVDRNEITVQGLKDLREELITEFPHVVLLTSDESWR AEDALGKMIVTSSVPLEHLNDSLKRKILDERTAEILNVLLQLWSTL*" /label="ypiF CDS" gene complement(2061439..2061885) /gene="ypiF" /locus_tag="BSU_22570" /old_locus_tag="BSU22570" /label="ypiF gene" downshifts 2061888 /Source="Nicolas_upshifts" /id="D1179" /incds=0 /nref=2 /ntot=54 /MaxReadThrough="0.94679" /MaxDrop="2.794" /score="0.352684802" /energy="-11.5" /TU="NA" /idTUdmin="U1763" /TUdmin=4191 /isTUend="FALSE" /label="downshifts" CDS complement(2061940..2062479) /gene="ypiB" /locus_tag="BSU_22580" /old_locus_tag="BSU22580" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16847875" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390139.1" /db_xref="EnsemblGenomes-Gn:BSU22580" /db_xref="EnsemblGenomes-Tr:CAB14174" /db_xref="InterPro:IPR011188" /db_xref="InterPro:IPR014957" /db_xref="InterPro:IPR014963" /db_xref="SubtiList:BG11497" /db_xref="UniProtKB/Swiss-Prot:P54390" /translation="MQTPVSVNEKKDFIRWFLNHYQLKRRECVWILNYLMSHDSLMEK VHFVEQAEFCPRGIIMSTHCVEEVPFRFYKENVMTTDAEKSFHDIRLNKQQDLFIQLN FRSAYSSPEYAAVLESNPHIPKNLFENKKDQGLAEQILEHAISTFQREKLLKDIDDAL DRHDKEAFEQLSRQLNQLT*" /label="ypiB CDS" gene complement(2061940..2062479) /gene="ypiB" /locus_tag="BSU_22580" /old_locus_tag="BSU22580" /label="ypiB gene" downshifts complement(2061953) /Source="Nicolas_upshifts" /id="D1180" /incds=0 /nref=84 /ntot=250 /MaxReadThrough="5.68366" /MaxDrop="5.48142" /score="16.8021869" /energy="-11.2" /TU="U1766,U1767" /idTUdmin="U1768" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2062512..2062530) /Source="Nicolas_upshift_promotors" /id="U1766" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=519 /SigmaFactorBS="attttgcgaatcgaggatgaattttctagataaGCAGGAATA ttaaccattcaTGTGGAACATATAAGTATAtagattatacgaacgatagaggagggaa t" /listShort="ypiB, ypiF, qcrA, qcrB" /listLong="qcrC, S854, ypjA, S853, ypjB" /label="promotor_-10" upshifts complement(2062523) /Source="Nicolas_upshifts" /id="U1766" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=519 /SigmaFactorBS="attttgcgaatcgaggatgaattttctagataaGCAGGAATA ttaaccattcaTGTGGAACATATAAGTATAtagattatacgaacgatagaggagggaa t" /listShort="ypiB, ypiF, qcrA, qcrB" /listLong="qcrC, S854, ypjA, S853, ypjB" /label="upshifts" promotor_-35 complement(2062542..2062550) /Source="Nicolas_upshift_promotors" /id="U1766" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=519 /SigmaFactorBS="attttgcgaatcgaggatgaattttctagataaGCAGGAATA ttaaccattcaTGTGGAACATATAAGTATAtagattatacgaacgatagaggagggaa t" /listShort="ypiB, ypiF, qcrA, qcrB" /listLong="qcrC, S854, ypjA, S853, ypjB" /label="promotor_-35" CDS complement(2062551..2063822) /gene="ypiA" /locus_tag="BSU_22590" /old_locus_tag="BSU22590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390140.1" /db_xref="EnsemblGenomes-Gn:BSU22590" /db_xref="EnsemblGenomes-Tr:CAB14175" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="SubtiList:BG11496" /db_xref="UniProtKB/Swiss-Prot:P54389" /translation="MNTLIQEAIKLVEAGETEKGLNTLSKAEKQLHDEDKAIAAQLYY EWGDVEKAISLISDLHDLYPNETELTNFYAELLIDIDEEEKALAVLETIPETDPSYPE SLLLMADLYQMQGLFEVSEQKLFQAKSILDNEPVIDFALGELYFAQGAYAKAVQYFKT TAEEQSEIGGVNVHQRLAESLSASGEFEDAIPWYEKAVDENPDPNTIFGYGFTALQAG LVKTAIKQLSDLKELDPSYTSLYMPLSKSYEAEGMYEEALKTAKEGIRYDEYNKELFL YAAKMALKIGKSEEGKKLLQEALALDPGFVEALHTLLAVYHKEEDYDQIIDLIQEVRS YGEEDPKYNWYLASAYTELEQYEEAKQSFEAAYLHYREDRDFLYEYASFLLEEGLQKE ALPLLKKVLEMDGANEELEETILRIEDEFSR*" /label="ypiA CDS" gene complement(2062551..2063822) /gene="ypiA" /locus_tag="BSU_22590" /old_locus_tag="BSU22590" /label="ypiA gene" S_feature complement(2063823..2063890) /Source="Nicolas_S_feature" /locus_tag="new_2367619_2367686_c" /HighExp="dia15, Diami, dia5, Etha, H2O2, T1.30H, LPhT, T0.30H, T3.0H, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigEF, SigA" /TUshortPSig="0.999, 0.999, 0.999, 1" /TUlongSig="Sig-, Sig-, SigA, SigA, SigA, SigA, SigA, SigA" /TUlongPSig="0.042, 0.047, 0.994, 0.999, 1, 0.999, 1, 0.998" /label="S855" promotor_-10 complement(2063887..2063906) /Source="Nicolas_upshift_promotors" /id="U1767" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.977022977022977" /psig="0.999000999001" /xcortree=2047 /SigmaFactorBS="ttcccttccgtacagaagcatctTATTTGCCgggggcattcg tcTGAATTATGATAAGATTAACccgaacaaataaagctttttttgtatggttgatgtt g" /listShort="S855, ypiA, ypiB, ypiF, qcrA, qcrB, qcrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2063890) /Source="Nicolas_upshifts" /id="U1767" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.977022977022977" /psig="0.999000999001" /xcortree=2047 /SigmaFactorBS="ttcccttccgtacagaagcatctTATTTGCCgggggcattcg tcTGAATTATGATAAGATTAACccgaacaaataaagctttttttgtatggttgatgtt g" /listShort="S855, ypiA, ypiB, ypiF, qcrA, qcrB, qcrC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2063920..2063927) /Source="Nicolas_upshift_promotors" /id="U1767" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.977022977022977" /psig="0.999000999001" /xcortree=2047 /SigmaFactorBS="ttcccttccgtacagaagcatctTATTTGCCgggggcattcg tcTGAATTATGATAAGATTAACccgaacaaataaagctttttttgtatggttgatgtt g" /listShort="S855, ypiA, ypiB, ypiF, qcrA, qcrB, qcrC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2063957..2063976) /Source="Nicolas_upshift_promotors" /id="U1768" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.788211788211788" /psig="0.999000999001" /xcortree=569 /SigmaFactorBS="ctgtacagagggcgatcttccttttttcaTTTTCTATctcaa gatctTTTGGTAAACTAATAAGACTcaataattcccttccgtacagaagcatcttatt t" /listShort="S855, ypiA, ypiB" /listLong="ypiF, qcrA, qcrB, qcrC, S854, ypjA, S853, ypjB" /label="promotor_-10" upshifts complement(2063963) /Source="Nicolas_upshifts" /id="U1768" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.788211788211788" /psig="0.999000999001" /xcortree=569 /SigmaFactorBS="ctgtacagagggcgatcttccttttttcaTTTTCTATctcaa gatctTTTGGTAAACTAATAAGACTcaataattcccttccgtacagaagcatcttatt t" /listShort="S855, ypiA, ypiB" /listLong="ypiF, qcrA, qcrB, qcrC, S854, ypjA, S853, ypjB" /label="upshifts" S_feature complement(2063965..2064109) /Source="Nicolas_S_feature" /locus_tag="new_2367761_2367905_c" /HighExp="S3, LoTm, M9-stat, S4, Etha, S5, T5.0H, BT, B36, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA, Sig-, SigA" /TUshortPSig="0.999, 1, 0.047, 0.994" /TUlongSig="Sig-, SigA, SigA, SigA, SigA, SigA" /TUlongPSig="0.042, 0.999, 1, 0.999, 1, 0.998" /label="S856" promotor_-35 complement(2063987..2063994) /Source="Nicolas_upshift_promotors" /id="U1768" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.788211788211788" /psig="0.999000999001" /xcortree=569 /SigmaFactorBS="ctgtacagagggcgatcttccttttttcaTTTTCTATctcaa gatctTTTGGTAAACTAATAAGACTcaataattcccttccgtacagaagcatcttatt t" /listShort="S855, ypiA, ypiB" /listLong="ypiF, qcrA, qcrB, qcrC, S854, ypjA, S853, ypjB" /label="promotor_-35" promotor_-10 complement(2064091..2064109) /Source="Nicolas_upshift_promotors" /id="U1769" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=983 /SigmaFactorBS="aaaaaatcctgaagttttacttcaggattttttatgcagATC ATAattcgaggcgaaaaaACATAGCTTGTCTTATAGAacggatagaaaaacgaaaagg g" /listShort="S856, S855, ypiA" /listLong="ypiB, ypiF, qcrA, qcrB, qcrC" /label="promotor_-10" upshifts complement(2064109) /Source="Nicolas_upshifts" /id="U1769" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=983 /SigmaFactorBS="aaaaaatcctgaagttttacttcaggattttttatgcagATC ATAattcgaggcgaaaaaACATAGCTTGTCTTATAGAacggatagaaaaacgaaaagg g" /listShort="S856, S855, ypiA" /listLong="ypiB, ypiF, qcrA, qcrB, qcrC" /label="upshifts" promotor_-35 complement(2064125..2064130) /Source="Nicolas_upshift_promotors" /id="U1769" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=983 /SigmaFactorBS="aaaaaatcctgaagttttacttcaggattttttatgcagATC ATAattcgaggcgaaaaaACATAGCTTGTCTTATAGAacggatagaaaaacgaaaagg g" /listShort="S856, S855, ypiA" /listLong="ypiB, ypiF, qcrA, qcrB, qcrC" /label="promotor_-35" CDS complement(2064158..2065444) /gene="aroA" /locus_tag="BSU_22600" /old_locus_tag="BSU22600" /EC_number="2.5.1.19" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 3106153, 22938038, 24628944; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvoylshikimate-3-phosphate synthase)" /protein_id="NP_390141.1" /db_xref="EnsemblGenomes-Gn:BSU22600" /db_xref="EnsemblGenomes-Tr:CAB14176" /db_xref="GOA:P20691" /db_xref="InterPro:IPR001986" /db_xref="InterPro:IPR006264" /db_xref="InterPro:IPR013792" /db_xref="InterPro:IPR023193" /db_xref="InterPro:IPR036968" /db_xref="SubtiList:BG10294" /db_xref="UniProtKB/Swiss-Prot:P20691" /translation="MKRDKVQTLHGEIHIPGDKSISHRSVMFGALAAGTTTVKNFLPG ADCLSTIDCFRKMGVHIEQSSSDVVIHGKGIDALKEPESLLDVGNSGTTIRLMLGILA GRPFYSAVAGDESIAKRPMKRVTEPLKKMGAKIDGRAGGEFTPLSVSGASLKGIDYVS PVASAQIKSAVLLAGLQAEGTTTVTEPHKSRDHTERMLSAFGVKLSEDQTSVSIAGGQ KLTAADIFVPGDISSAAFFLAAGAMVPNSRIVLKNVGLNPTRTGIIDVLQNMGAKLEI KPSADSGAEPYGDLIIETSSLKAVEIGGDIIPRLIDEIPIIALLATQAEGTTVIKDAA ELKVKETNRIDTVVSELRKLGAEIEPTADGMKVYGKQTLKGGAAVSSHGDHRIGMMLG IASCITEEPIEIEHTDAIHVSYPTFFEHLNKLSKKS*" /label="aroA CDS" gene complement(2064158..2065444) /gene="aroA" /locus_tag="BSU_22600" /old_locus_tag="BSU22600" /label="aroA gene" downshifts complement(2064181) /Source="Nicolas_upshifts" /id="D1181" /incds=0 /nref=68 /ntot=212 /MaxReadThrough="3.64462" /MaxDrop="4.25336" /score="16.8021869" /energy="-11.2" /TU="U1770,U1772,U1773" /idTUdmin="U1775" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" CDS complement(2065455..2066570) /gene="tyrA" /locus_tag="BSU_22610" /old_locus_tag="BSU22610" /EC_number="1.3.1.12" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:3106153, 3121591" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3106153, 3121591; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="prephenate dehydrogenase" /protein_id="NP_390142.1" /db_xref="EnsemblGenomes-Gn:BSU22610" /db_xref="EnsemblGenomes-Tr:CAB14177" /db_xref="GOA:P20692" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR003099" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10293" /db_xref="UniProtKB/Swiss-Prot:P20692" /translation="MNQMKDTILLAGLGLIGGSIALAIKKNHPGKRIIGIDISDEQAV AALKLGVIDDRADSFISGVKEAATVIIATPVEQTLVMLEELAHSGIEHELLITDVGST KQKVVDYADQVLPSRYQFVGGHPMAGSHKSGVAAAKEFLFENAFYILTPGQKTDKQAV EQLKNLLKGTNAHFVEMSPEEHDGVTSVISHFPHIVAASLVHQTHHSENLYPLVKRFA AGGFRDITRIASSSPAMWRDILLHNKDKILDRFDEWIREIDKIRTYVEQEDAENLFRY FKTAKDYRDGLPLRQKGAIPAFYDLYVDVPDHPGVISEITAILAAERISITNIRIIET REDINGILRISFQSDDDRKRAEQCIEARAEYETFYAD*" /label="tyrA CDS" gene complement(2065455..2066570) /gene="tyrA" /locus_tag="BSU_22610" /old_locus_tag="BSU22610" /label="tyrA gene" CDS complement(2066619..2067701) /gene="hisC" /locus_tag="BSU_22620" /old_locus_tag="BSU22620" /EC_number="2.6.1.5" /EC_number="2.6.1.9" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:4431, 418816, 824269, 11518529, 15102328" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4431, 418816, 824269, 11518529, 15102328; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="histidinol-phosphate aminotransferase; tyrosine/phenylalanine aminotransferase (promiscuous)" /protein_id="NP_390143.2" /db_xref="EnsemblGenomes-Gn:BSU22620" /db_xref="EnsemblGenomes-Tr:CAB14178" /db_xref="GOA:P17731" /db_xref="InterPro:IPR001917" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR005861" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG10292" /db_xref="UniProtKB/Swiss-Prot:P17731" /translation="MRIKEHLKQLKPYQPGKPIEAVKSEYGLDKVVKLASNENPYGCS EAAKEALHHEIQQLALYPDGYSAALRTRLSKHLNVSETSLIFGNGSDEIIQIICRAFL NDKTNTVTAAPTFPQYKHNAVIEGAEVREIALRPDGSHDLDAMLEAIDEQTQVVWICS PNNPTGTYTSEGELLAFLERVPSRVLVVLDEAYYEYVTAEDYPETVPLLSKYSNLMIL RTFSKAYGLAALRVGYGIADENLIRQIEPAREPFNTSRLGQAAAIAALDDQAFIASCV EQNNAGLQQYYDFAKTHGLKCYPSQTNFVLIDFKRPADELFQALLEKGYIVRSGNALG FPTSLRITIGTKEQNEEILAILAEIL*" /label="hisC CDS" gene complement(2066619..2067701) /gene="hisC" /locus_tag="BSU_22620" /old_locus_tag="BSU22620" /label="hisC gene" CDS complement(2067712..2068515) /gene="trpA" /locus_tag="BSU_22630" /old_locus_tag="BSU22630" /EC_number="4.2.1.20" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2422155, 9383185, 10714985, 12963367, 17114058, 17555270" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2422155, 9383185, 10714985, 12963367, 17114058, 17555270; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="tryptophan synthase (alpha subunit)" /protein_id="NP_390144.1" /db_xref="EnsemblGenomes-Gn:BSU22630" /db_xref="EnsemblGenomes-Tr:CAB14179" /db_xref="GOA:P07601" /db_xref="InterPro:IPR002028" /db_xref="InterPro:IPR011060" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR018204" /db_xref="SubtiList:BG10291" /db_xref="UniProtKB/Swiss-Prot:P07601" /translation="MFKLDLQPSEKLFIPFITAGDPVPEVSIELAKSLQKAGATALEL GVAYSDPLADGPVIQRASKRALDQGMNIVKAIELGGEMKKNGVNIPIILFTYYNPVLQ LNKEYFFALLRENHIDGLLVPDLPLEESNSLQEECKSHEVTYISLVAPTSESRLKTII EQAEGFVYCVSSLGVTGVRNEFNSSVYPFIRTVKNLSTVPVAVGFGISNREQVIKMNE ISDGVVVGSALVRKIEELKDRLISAETRNQALQEFEDYAMAFSGLYSLK*" /label="trpA CDS" gene complement(2067712..2068515) /gene="trpA" /locus_tag="BSU_22630" /old_locus_tag="BSU22630" /label="trpA gene" promotor_-10 complement(2068200..2068219) /Source="Nicolas_upshift_promotors" /id="U1770" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.598401598401598" /psig=1 /xcortree=3019 /SigmaFactorBS="gagaaatgaaaaaaaacggagtgaatattccgattatccTCT TTACGtattataatccTGTGTTACAATTGAACAAAGaatactttttcgctttactgcg g" /listShort="hisC, tyrA, aroE, S856, S855, ypiA" /listLong="ypiB, ypiF, qcrA, qcrB, qcrC" /label="promotor_-10" upshifts complement(2068217) /Source="Nicolas_upshifts" /id="U1770" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.598401598401598" /psig=1 /xcortree=3019 /SigmaFactorBS="gagaaatgaaaaaaaacggagtgaatattccgattatccTCT TTACGtattataatccTGTGTTACAATTGAACAAAGaatactttttcgctttactgcg g" /listShort="hisC, tyrA, aroE, S856, S855, ypiA" /listLong="ypiB, ypiF, qcrA, qcrB, qcrC" /label="upshifts" promotor_-35 complement(2068231..2068238) /Source="Nicolas_upshift_promotors" /id="U1770" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.598401598401598" /psig=1 /xcortree=3019 /SigmaFactorBS="gagaaatgaaaaaaaacggagtgaatattccgattatccTCT TTACGtattataatccTGTGTTACAATTGAACAAAGaatactttttcgctttactgcg g" /listShort="hisC, tyrA, aroE, S856, S855, ypiA" /listLong="ypiB, ypiF, qcrA, qcrB, qcrC" /label="promotor_-35" CDS complement(2068508..2069710) /gene="trpB" /locus_tag="BSU_22640" /old_locus_tag="BSU22640" /EC_number="4.2.1.20" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2422155, 3062311, 9383185, 10714985, 12963367, 17114058, 17555270" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2422155, 3062311, 9383185, 10714985, 12963367, 17114058, 17555270; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tryptophan synthase (beta subunit)" /protein_id="NP_390145.2" /db_xref="EnsemblGenomes-Gn:BSU22640" /db_xref="EnsemblGenomes-Tr:CAB14180" /db_xref="GOA:P07600" /db_xref="InterPro:IPR001926" /db_xref="InterPro:IPR006653" /db_xref="InterPro:IPR006654" /db_xref="InterPro:IPR023026" /db_xref="InterPro:IPR036052" /db_xref="SubtiList:BG10290" /db_xref="UniProtKB/Swiss-Prot:P07600" /translation="MYPYPNEIGRYGDFGGKFVPETLMQPLDEIQTAFKQIKDDPAFR EEYYKLLKDYSGRPTALTYADRVTEYLGGAKIYLKREDLNHTGSHKINNALGQALLAK KMGKTKIIAETGAGQHGVAAATVAAKFGFSCTVFMGEEDVARQSLNVFRMKLLGAEVV PVTSGNGTLKDATNEAIRYWVQHCEDHFYMIGSVVGPHPYPQVVREFQKMIGEEAKDQ LKRIEGTMPDKVVACVGGGSNAMGMFQAFLNEDVELIGAEAAGKGIDTPLHAATISKG TVGVIHGSLTYLIQDEFGQIIEPYSISAGLDYPGIGPEHAYLHKSGRVTYDSITDEEA VDALKLLSEKEGILPAIESAHALAKAFKLAKGMDRGQLILVCLSGRGDKDVNTLMNVL EEEVKAHV*" /label="trpB CDS" gene complement(2068508..2069710) /gene="trpB" /locus_tag="BSU_22640" /old_locus_tag="BSU22640" /label="trpB gene" CDS complement(2069691..2070338) /gene="trpF" /locus_tag="BSU_22650" /old_locus_tag="BSU22650" /EC_number="5.3.1.24" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2422155, 9383185, 10714985, 12963367, 17114058" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2422155, 9383185, 10714985, 12963367, 17114058; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylanthranilate isomerase" /protein_id="NP_390146.3" /db_xref="EnsemblGenomes-Gn:BSU22650" /db_xref="EnsemblGenomes-Tr:CAB14181" /db_xref="GOA:P20167" /db_xref="InterPro:IPR001240" /db_xref="InterPro:IPR011060" /db_xref="InterPro:IPR013785" /db_xref="SubtiList:BG10289" /db_xref="UniProtKB/Swiss-Prot:P20167" /translation="MKKPALKYCGIRSLKDLQLAAESQADYLGFIFAESKRKVSPEDV KKWLNQVRVEKQVAGVFVNESIETMSRIAKSLKLDVIQLHGDEKPADAAALRKLTGCE IWKALHHQDNTTQEIARFKDNVDGFVIDSSVKGSRGGTGVAFSWECVPEYQQAAIGKR CFIAGGVNPDSITRLLKWQPEGIDLASGIEKNGQKDQNLMRLLEERMNRYVSISE*" /label="trpF CDS" gene complement(2069691..2070338) /gene="trpF" /locus_tag="BSU_22650" /old_locus_tag="BSU22650" /label="trpF gene" downshifts complement(2069785) /Source="Nicolas_upshifts" /id="D1182" /incds=1 /nref=30 /ntot=83 /MaxReadThrough="8.17917" /MaxDrop="5.75867" /score="2.96963632" /energy="-11.9" /TU="U1771,U1772,U1773,U1775" /idTUdmin="U1774" /TUdmin=616 /isTUend="FALSE" /label="downshifts" misc_feature complement(2069961..2069964) /Source="Nicolas_upshift_promotors" /id="U1771" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.394605394605395" /psig="0.041958041958042" /xcortree=2849 /SigmaFactorBS="gcttcaccatcaagataacacaactcaagaaatagcccgctt taaagataatgttgaCGGCtttgtgattgattcatctgtaaaagggtctagaggcgga a" /listShort="trpB, trpA" /listLong="hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2069961) /Source="Nicolas_upshifts" /id="U1771" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.394605394605395" /psig="0.041958041958042" /xcortree=2849 /SigmaFactorBS="gcttcaccatcaagataacacaactcaagaaatagcccgctt taaagataatgttgaCGGCtttgtgattgattcatctgtaaaagggtctagaggcgga a" /listShort="trpB, trpA" /listLong="hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="upshifts" downshifts complement(2070181) /Source="Nicolas_upshifts" /id="D1183" /incds=1 /nref=1 /ntot=84 /MaxReadThrough="8.55417" /MaxDrop="3.4408" /score="2.96963632" /energy="-11.9" /TU="U1772,U1773,U1775" /idTUdmin="U1774" /TUdmin=220 /isTUend="FALSE" /label="downshifts" misc_feature 2070343..2071095 /created_by="AR/SM" /id="IIG_Bs01" /note="due to the curing of the trpC2 locus (auxotrophy) of the Delta6 strain by transformation with chromosomal DNA from donor Bsu 3NA multiple snp`s were transferred to the oroginal trpC locus" /modified_by="User" /label="IIG_Bs01" /note="Geneious type: MiniBacillus__exchange" CDS complement(2070343..2071095) /locus_tag="PG10_trpC_var_BEP06_07765" /inference="EXISTENCE: similar to AA sequence:RefSeq:WP_007409461.1" /note="Derived by automated computational analysis using gene prediction method: Protein Homology." /codon_start=1 /transl_table=11 /product="indole-3-glycerol phosphate synthase" /protein_id="ANY35339.1" /old_locus_tag="BSU_22660" /gene="trpC" /modified_by="User" /translation="MLEKIIKQKKEEVKTLVLPVEQPFEKRSFKEALASLNRFIGLIA EVKKASPSKGLIKENFVPVRIAKDYETAKADALSVLTDTPFFQGENSYLSDVKRAVSI PVLRKDFIIDSLQVEESRRIGADAILLIGEVLDPLHLHELYLEAGEKEMDVLVEVHDA TTLEQILKVFTPDILGINNRNLKTFETSIMQTEQIASLAPKESLLVSESGIGSLEHLT FVKEHGARAVLIGESLMRQTSQRKAIHALFRE*" /label="PG10_trpC_var_BEP06_07765" gene complement(2070343..2071095) /locus_tag="PG10_trpC_var_BEP06_07765" /old_locus_tag="BSU_22660" /gene="trpC" /modified_by="User" /label="PG10_trpC_var_BEP06_07765" misc_feature complement(2070376..2070378) /Source="Nicolas_upshift_promotors" /id="U1772" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.43956043956044" /psig="0.046953046953047" /xcortree=2850 /SigmaFactorBS="tgtcaatgaacatggggcgcgagctgtacttatcggtgaatc attgatgagacaaacttctCAGcgtaaagcaatccatgctttgtttagggagtgaggt t" /listShort="trpF, trpB, trpA, hisC, tyrA, aroE, S856" /listLong="S855, ypiA, ypiB, ypiF, qcrA, qcrB" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2070379 /Source="Nicolas_upshifts" /id="U1772" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.43956043956044" /psig="0.046953046953047" /xcortree=2850 /SigmaFactorBS="tgtcaatgaacatggggcgcgagctgtacttatcggtgaatc attgatgagacaaacttctCAGcgtaaagcaatccatgctttgtttagggagtgaggt t" /listShort="trpF, trpB, trpA, hisC, tyrA, aroE, S856" /listLong="S855, ypiA, ypiB, ypiF, qcrA, qcrB" /label="upshifts" Polymorphism join(2070485,2070488) /Source="geneious" /ID="SNP_BsPG10_2374282_2374283" /Polymorphism_Type="Substitution" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=2 /Amino_Acid_Change /CDS_Position=606 /Change="AG -> GT" /Codon_Change="TCC,TTG -> TCA,CTG" /Coverage="129 -> 130" /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="AG" /Variant_Nucleotides="GT" /Variant_P_Value="2e-203" /Variant_Raw_Frequency="128 -> 129" /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(2070499,2070501) /Source="geneious" /ID="SNP_BsPG10_2374296_2374296" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change="V -> A" /CDS_Position=593 /Change="A -> G" /Codon_Change="GTT -> GCT" /Coverage=119 /locus_tag="BSU_22660" /Protein_Effect="Substitution" /Reference_Frequency /Reference_Nucleotides="A" /Variant_Nucleotides="G" /Variant_P_Value="3.2e-179" /Variant_Raw_Frequency=119 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(2070501,2070503) /Source="geneious" /ID="SNP_BsPG10_2374298_2374298" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=591 /Change="G -> A" /Codon_Change="CTC -> CTT" /Coverage=118 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="G" /Variant_Nucleotides="A" /Variant_P_Value="9.9e-148" /Variant_Raw_Frequency=116 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(2070526,2070528) /Source="geneious" /ID="SNP_BsPG10_2374323_2374323" /Polymorphism_Type="SNP (transversion)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change="K -> M" /CDS_Position=566 /Change="T -> A" /Codon_Change="AAG -> ATG" /Coverage=81 /locus_tag="BSU_22660" /Protein_Effect="Substitution" /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides="A" /Variant_P_Value="6.3e-98" /Variant_Raw_Frequency=81 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(2070528,2070532) /Source="geneious" /ID="SNP_BsPG10_2374325_2374327" /Polymorphism_Type="Substitution" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=2 /Amino_Acid_Change="V -> I" /CDS_Position=562 /Change="TAC -> GAT" /Codon_Change="GTA -> ATC" /Coverage="79 -> 84" /locus_tag="BSU_22660" /Protein_Effect="Substitution" /Reference_Frequency /Reference_Nucleotides="TAC" /Variant_Nucleotides="GAT" /Variant_P_Value="2.3e-77" /Variant_Raw_Frequency="74 -> 78" /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(2070534,2070536) /Source="geneious" /ID="SNP_BsPG10_2374331_2374331" /Polymorphism_Type="SNP (transversion)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=558 /Change="T -> G" /Codon_Change="ACA -> ACC" /Coverage=70 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides="G" /Variant_P_Value="1e-63" /Variant_Raw_Frequency=70 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(2070543,2070545) /Source="geneious" /ID="SNP_BsPG10_2374340_2374340" /Polymorphism_Type="SNP (transversion)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=549 /Change="C -> A" /Codon_Change="ACG -> ACT" /Coverage=59 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="C" /Variant_Nucleotides="A" /Variant_P_Value="1e-59" /Variant_Raw_Frequency=59 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(2070558,2070560) /Source="geneious" /ID="SNP_BsPG10_2374355_2374355" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=534 /Change="A -> G" /Codon_Change="AAT -> AAC" /Coverage=66 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="A" /Variant_Nucleotides="G" /Variant_P_Value="6e-64" /Variant_Raw_Frequency=65 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(2070561,2070563) /Source="geneious" /ID="SNP_BsPG10_2374358_2374358" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=531 /Change="A -> G" /Codon_Change="AAT -> AAC" /Coverage=63 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="A" /Variant_Nucleotides="G" /Variant_P_Value="3.3e-68" /Variant_Raw_Frequency=60 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(2070566,2070568) /Source="geneious" /ID="SNP_BsPG10_2374363_2374363" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change="V -> I" /CDS_Position=526 /Change="C -> T" /Codon_Change="GTA -> ATA" /Coverage=65 /locus_tag="BSU_22660" /Protein_Effect="Substitution" /Reference_Frequency /Reference_Nucleotides="C" /Variant_Nucleotides="T" /Variant_P_Value="3.9e-82" /Variant_Raw_Frequency=64 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(2070576,2070578) /Source="geneious" /ID="SNP_BsPG10_2374373_2374373" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=516 /Change="G -> A" /Codon_Change="GAC -> GAT" /Coverage=79 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="G" /Variant_Nucleotides="A" /Variant_P_Value="7.7e-116" /Variant_Raw_Frequency=78 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(2070579,2070581) /Source="geneious" /ID="SNP_BsPG10_2374376_2374376" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=513 /Change="G -> A" /Codon_Change="CCC -> CCT" /Coverage=92 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="G" /Variant_Nucleotides="A" /Variant_P_Value="4e-141" /Variant_Raw_Frequency=90 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(2070582,2070584) /Source="geneious" /ID="SNP_BsPG10_2374379_2374379" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=510 /Change="T -> C" /Codon_Change="ACA -> ACG" /Coverage=97 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides="C" /Variant_P_Value="1.3e-165" /Variant_Raw_Frequency=97 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(2070588,2070590) /Source="geneious" /ID="SNP_BsPG10_2374385_2374385" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=504 /Change="C -> T" /Codon_Change="GTG -> GTA" /Coverage=109 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="C" /Variant_Nucleotides="T" /Variant_P_Value="4.3e-193" /Variant_Raw_Frequency=108 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(2070614,2070616) /Source="geneious" /ID="SNP_BsPG10_2374411_2374411" /Polymorphism_Type="SNP (transversion)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change="S -> T" /CDS_Position=478 /Change="A -> T" /Codon_Change="TCA -> ACA" /Coverage=148 /locus_tag="BSU_22660" /Protein_Effect="Substitution" /Reference_Frequency /Reference_Nucleotides="A" /Variant_Nucleotides="T" /Variant_P_Value="2.9e-307" /Variant_Raw_Frequency=147 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(2070646,2070648) /Source="geneious" /ID="SNP_BsPG10_2374443_2374443" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change="G -> E" /CDS_Position=446 /Change="C -> T" /Codon_Change="GGG -> GAG" /Coverage=161 /locus_tag="BSU_22660" /Protein_Effect="Substitution" /Reference_Frequency /Reference_Nucleotides="C" /Variant_Nucleotides="T" /Variant_P_Value=0 /Variant_Raw_Frequency=161 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(2070699,2070701) /Source="geneious" /ID="SNP_BsPG10_2374496_2374496" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=393 /Change="C -> T" /Codon_Change="GAG -> GAA" /Coverage=174 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="C" /Variant_Nucleotides="T" /Variant_P_Value=0 /Variant_Raw_Frequency=174 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(2070747,2070749) /Source="geneious" /ID="SNP_BsPG10_2374544_2374544" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=345 /Change="T -> C" /Codon_Change="GTA -> GTG" /Coverage=168 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides="C" /Variant_P_Value=0 /Variant_Raw_Frequency=167 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(2070762,2070766) /Source="geneious" /ID="SNP_BsPG10_2374559_2374558" /Polymorphism_Type="Insertion" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=0 /Amino_Acid_Change="-> I" /CDS_Position=331 /Change="AAT" /Codon_Change="-> ATT" /Coverage=164 /locus_tag="BSU_22660" /Protein_Effect="Insertion" /Reference_Frequency /Reference_Nucleotides /Variant_Nucleotides="AAT" /Variant_P_Value="3.90000001038273e-316" /Variant_Raw_Frequency=147 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(2070780,2070782) /Source="geneious" /ID="SNP_BsPG10_2374574_2374574" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=315 /Change="A -> G" /Codon_Change="CTT -> CTC" /Coverage=155 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="A" /Variant_Nucleotides="G" /Variant_P_Value=0 /Variant_Raw_Frequency=154 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(2070789,2070791) /Source="geneious" /ID="SNP_BsPG10_2374583_2374583" /Polymorphism_Type="SNP (transversion)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=306 /Change="A -> T" /Codon_Change="ATT -> ATA" /Coverage=153 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="A" /Variant_Nucleotides="T" /Variant_P_Value=0 /Variant_Raw_Frequency=152 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(2070801,2070803) /Source="geneious" /ID="SNP_BsPG10_2374595_2374595" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=294 /Change="A -> G" /Codon_Change="CGT -> CGC" /Coverage=128 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="A" /Variant_Nucleotides="G" /Variant_P_Value="4e-295" /Variant_Raw_Frequency=128 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(2070866,2070868) /Source="geneious" /ID="SNP_BsPG10_2374660_2374660" /Polymorphism_Type="SNP (transversion)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change="I -> L" /CDS_Position=229 /Change="T -> G" /Codon_Change="ATT -> CTT" /Coverage=131 /locus_tag="BSU_22660" /Protein_Effect="Substitution" /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides="G" /Variant_P_Value="2.3e-302" /Variant_Raw_Frequency=128 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(2070876,2070878) /Source="geneious" /ID="SNP_BsPG10_2374670_2374670" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=219 /Change="C -> T" /Codon_Change="AAG -> AAA" /Coverage=126 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="C" /Variant_Nucleotides="T" /Variant_P_Value="1.6e-290" /Variant_Raw_Frequency=126 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(2070884,2070887) /Source="geneious" /ID="SNP_BsPG10_2374678_2374679" /Polymorphism_Type="Substitution" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=2 /Amino_Acid_Change="EA -> ET" /CDS_Position=210 /Change="CC -> TT" /Codon_Change="GAG,GCT -> GAA,ACT" /Coverage="124 -> 130" /locus_tag="BSU_22660" /Protein_Effect="Substitution" /Reference_Frequency /Reference_Nucleotides="CC" /Variant_Nucleotides="TT" /Variant_P_Value="4.7e-253" /Variant_Raw_Frequency="119 -> 125" /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(2070904,2070906) /Source="geneious" /ID="SNP_BsPG10_2374698_2374698" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change="Q -> R" /CDS_Position=191 /Change="T -> C" /Codon_Change="CAG -> CGG" /Coverage=104 /locus_tag="BSU_22660" /Protein_Effect="Substitution" /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides="C" /Variant_P_Value="9e-228" /Variant_Raw_Frequency=101 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(2070920,2070922) /Source="geneious" /ID="SNP_BsPG10_2374714_2374714" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change="D -> N" /CDS_Position=175 /Change="C -> T" /Codon_Change="GAT -> AAT" /Coverage=95 /locus_tag="BSU_22660" /Protein_Effect="Substitution" /Reference_Frequency="1.1%" /Reference_Nucleotides="C" /Variant_Nucleotides="T" /Variant_P_Value="2.8e-220" /Variant_Raw_Frequency=93 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(2070948,2070950) /Source="geneious" /ID="SNP_BsPG10_2374742_2374742" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=147 /Change="T -> C" /Codon_Change="GCA -> GCG" /Coverage=98 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides="C" /Variant_P_Value="1.2e-260" /Variant_Raw_Frequency=97 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(2070963,2070965) /Source="geneious" /ID="SNP_BsPG10_2374757_2374757" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=132 /Change="G -> A" /Codon_Change="GCC -> GCT" /Coverage=197 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="G" /Variant_Nucleotides="A" /Variant_P_Value /Variant_Raw_Frequency /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(2070988,2070990) /Source="geneious" /ID="SNP_BsPG10_2374782_2374782" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change="P -> L" /CDS_Position=107 /Change="G -> A" /Codon_Change="CCG -> CTG" /Coverage=118 /locus_tag="BSU_22660" /Protein_Effect="Substitution" /Reference_Frequency /Reference_Nucleotides="G" /Variant_Nucleotides="A" /Variant_P_Value=0 /Variant_Raw_Frequency=118 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(2071005,2071007) /Source="geneious" /ID="SNP_BsPG10_2374799_2374799" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=90 /Change="C -> T" /Codon_Change="AAG -> AAA" /Coverage=133 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="C" /Variant_Nucleotides="T" /Variant_P_Value=0 /Variant_Raw_Frequency=131 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" Polymorphism join(2071020,2071022) /Source="geneious" /ID="SNP_BsPG10_2374814_2374814" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis PG10" /Length=1 /Amino_Acid_Change /CDS_Position=75 /Change="C -> T" /Codon_Change="GAG -> GAA" /Coverage=130 /locus_tag="BSU_22660" /Protein_Effect="None" /Reference_Frequency /Reference_Nucleotides="C" /Variant_Nucleotides="T" /Variant_P_Value=0 /Variant_Raw_Frequency=130 /comment="trpC_3NA" /modified_by="User" /label="Polymorphism_PG10" CDS complement(2071088..2072104) /gene="trpD" /locus_tag="BSU_22670" /old_locus_tag="BSU22670" /EC_number="2.4.2.18" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2422155, 9383185, 17555270, 10714985, 12963367, 17114058" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2422155, 9383185, 17555270, 10714985, 12963367, 17114058; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="anthranilate phosphoribosyltransferase" /protein_id="NP_390148.2" /db_xref="EnsemblGenomes-Gn:BSU22670" /db_xref="EnsemblGenomes-Tr:CAB14183" /db_xref="GOA:P03947" /db_xref="InterPro:IPR000312" /db_xref="InterPro:IPR005940" /db_xref="InterPro:IPR017459" /db_xref="InterPro:IPR035902" /db_xref="InterPro:IPR036320" /db_xref="SubtiList:BG10288" /db_xref="UniProtKB/Swiss-Prot:P03947" /modified_by="User" /translation="MNRFLQLCVDGKTLTAGEAETLMNMMMAAEMTPSEMGGILSILA HRGETPEELAGFVKAMRAHALTVDGLPDIVDTCGTGGDGISTFNISTASAIVASAAGA KIAKHGNRSVSSKSGSADVLEELEVSIQTTPEKVKSSIETNNMGFLFAPLYHSSMKHV AGTRKELGFRTVFNLLGPLSNPLQAKRQVIGVYSVEKAGLMASALETFQPKHVMFVSS RDGLDELSITAPTDVIELKDGERREYTVSPEDFGFTNGRLEDLQVQSPKESAYLIQNI FENKSSSSALSITAFNAGAAIYTAGITASLKEGTELALETITSGGAAAQLERLKQKEE EIYA*" /label="trpD CDS" gene complement(2071088..2072104) /gene="trpD" /locus_tag="BSU_22670" /old_locus_tag="BSU22670" /modified_by="User" /label="trpD gene" CDS complement(2072076..2073623) /gene="trpE" /locus_tag="BSU_22680" /old_locus_tag="BSU22680" /EC_number="4.1.3.27" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2422155, 9383185, 17555270, 10714985, 12963367, 15063849, 17114058" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2422155, 9383185, 17555270, 10714985, 12963367, 15063849, 17114058; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="anthranilate synthase" /protein_id="NP_390149.1" /db_xref="EnsemblGenomes-Gn:BSU22680" /db_xref="EnsemblGenomes-Tr:CAB14184" /db_xref="GOA:P03963" /db_xref="InterPro:IPR005256" /db_xref="InterPro:IPR005801" /db_xref="InterPro:IPR006805" /db_xref="InterPro:IPR015890" /db_xref="InterPro:IPR019999" /db_xref="SubtiList:BG10287" /db_xref="UniProtKB/Swiss-Prot:P03963" /translation="MNFQSNISAFLEDSLSHHTIPIVETFTVDTLTPIQMIEKLDREI TYLLESKDDTSTWSRYSFIGLNPFLTIKEEQGRFSAADQDSKSLYTGNELKEVLNWMN TTYKIKTPELGIPFVGGAVGYLSYDMIPLIEPSVPSHTKETDMEKCMLFVCRTLIAYD HETKNVHFIQYARLTGEETKNEKMDVFHQNHLELQNLIEKMMDQKNIKELFLSADSYK TPSFETVSSNYEKSAFMADVEKIKSYIKAGDIFQGVLSQKFEVPIKADAFELYRVLRI VNPSPYMYYMKLLDREIVGSSPERLIHVQDGHLEIHPIAGTRKRGADKAEDERLKVEL MKDEKEKAEHYMLVDLARNDIGRVAEYGSVSVPEFTKIVSFSHVMHIISVVTGRLKKG VHPVDALMSAFPAGTLTGAPKIRAMQLLQELEPTPRETYGGCIAYIGFDGNIDSCITI RTMSVKNGVASIQAGAGIVADSVPEAEYEESCNKAGALLKTIHIAEDMFHSKEDKADE QISTIVR*" /label="trpE CDS" gene complement(2072076..2073623) /gene="trpE" /locus_tag="BSU_22680" /old_locus_tag="BSU22680" /label="trpE gene" S_feature complement(2073702..2073833) /Source="Nicolas_S_feature" /locus_tag="new_2377495_2377626_c" /HighExp="Etha, S1, GM 25, GM 15, HiTm, Glu, MG-0.1, GM 60, M9-exp, GM 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigWXY, SigA, SigA, SigA" /TUshortPSig="0.994, 0.647, 0.999, 1, 0.996" /TUlongSig="SigA, SigA, SigA" /TUlongPSig="0.999, 1, 0.998" /label="S857" downshifts complement(2073745) /Source="Nicolas_upshifts" /id="D1184" /incds=0 /nref=61 /ntot=157 /MaxReadThrough="7.41666" /MaxDrop="5.25158" /score="2.96963632" /energy="-11.9" /TU="U1773,U1774,U1775,U1776" /idTUdmin="U1777" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2073824..2073843) /Source="Nicolas_upshift_promotors" /id="U1773" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.52047952047952" /psig="0.994005994005994" /xcortree=401 /SigmaFactorBS="aaaagttgtcgtattgaggcccgatttaTCATTGACaaaaaa tactgaatTGTAATACGATAAGAACAGCttagaaatacacaagagtgtgtataaagca a" /listShort="S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856" /listLong="S855, ypiA, ypiB, ypiF, qcrA, qcrB" /label="promotor_-10" upshifts complement(2073833) /Source="Nicolas_upshifts" /id="U1773" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.52047952047952" /psig="0.994005994005994" /xcortree=401 /SigmaFactorBS="aaaagttgtcgtattgaggcccgatttaTCATTGACaaaaaa tactgaatTGTAATACGATAAGAACAGCttagaaatacacaagagtgtgtataaagca a" /listShort="S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856" /listLong="S855, ypiA, ypiB, ypiF, qcrA, qcrB" /label="upshifts" CDS complement(2073839..2074222) /gene="aroH" /locus_tag="BSU_22690" /old_locus_tag="BSU22690" /EC_number="5.4.99.5" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2105742, 8378335, 9384560, 10818343, 15865424, 16060652, 28743924" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2105742, 8378335, 9384560, 10818343, 15865424, 16060652, 28743924; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="chorismate mutase" /protein_id="NP_390150.1" /db_xref="EnsemblGenomes-Gn:BSU22690" /db_xref="EnsemblGenomes-Tr:CAB14185" /db_xref="GOA:P19080" /db_xref="InterPro:IPR008243" /db_xref="InterPro:IPR035959" /db_xref="PDB:1COM" /db_xref="PDB:1DBF" /db_xref="PDB:1FNJ" /db_xref="PDB:1FNK" /db_xref="PDB:2CHS" /db_xref="PDB:2CHT" /db_xref="PDB:3ZO8" /db_xref="PDB:3ZOP" /db_xref="PDB:3ZP4" /db_xref="PDB:3ZP7" /db_xref="SubtiList:BG10286" /db_xref="UniProtKB/Swiss-Prot:P19080" /translation="MMIRGIRGATTVERDTEEEILQKTKQLLEKIIEENHTKPEDVVQ MLLSATPDLHAVFPAKAVRELSGWQYVPVTCMQEMDVTGGLKKCIRVMMTVQTDVPQD QIRHVYLEKVVVLRPDLSLTKNTEL*" /label="aroH CDS" gene complement(2073839..2074222) /gene="aroH" /locus_tag="BSU_22690" /old_locus_tag="BSU22690" /label="aroH gene" promotor_-35 complement(2073858..2073865) /Source="Nicolas_upshift_promotors" /id="U1773" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.52047952047952" /psig="0.994005994005994" /xcortree=401 /SigmaFactorBS="aaaagttgtcgtattgaggcccgatttaTCATTGACaaaaaa tactgaatTGTAATACGATAAGAACAGCttagaaatacacaagagtgtgtataaagca a" /listShort="S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856" /listLong="S855, ypiA, ypiB, ypiF, qcrA, qcrB" /label="promotor_-35" CDS complement(2074219..2075307) /gene="aroB" /locus_tag="BSU_22700" /old_locus_tag="BSU22700" /EC_number="4.2.3.4" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:97285, 97286, 6795181, 24628944" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 97285, 97286, 6795181, 24628944; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-dehydroquinate synthase" /protein_id="NP_390151.1" /db_xref="EnsemblGenomes-Gn:BSU22700" /db_xref="EnsemblGenomes-Tr:CAB14186" /db_xref="GOA:P31102" /db_xref="InterPro:IPR016037" /db_xref="InterPro:IPR030960" /db_xref="InterPro:IPR030963" /db_xref="SubtiList:BG10285" /db_xref="UniProtKB/Swiss-Prot:P31102" /translation="MKTLHVQTASSSYPVFIGQGIRKKACELLTSLNRPLTRIMFVTD EEVDRLYGDEMLHLLQEKWPVKKVTVPSGEQAKSMDMYTKLQSEAIRFHMDRSSCIIA FGGGVVGDLAGFVAATFMRGIDFIQMPTTLLAHDSAVGGKVAVNHPLGKNLIGAFYQP KAVLYDTDFLRSLPEKELRSGMAEVIKHAFIYDRAFLEELLNIHSLRDITNDQLNDMI FKGISIKASVVQQDEKEEGIRAYLNFGHTLGHAVEAEYGYGQITHGDAVALGMQFALY ISEKTVGCEMDRKRLVSWLKSLGYPSQIRKETETSVLLNRMMNDKKTRGGKIQFIVLN ELGKVADHTFSRNELESWLNKWRLEETS*" /label="aroB CDS" gene complement(2074219..2075307) /gene="aroB" /locus_tag="BSU_22700" /old_locus_tag="BSU22700" /label="aroB gene" promotor_-10 complement(2074348..2074363) /Source="Nicolas_upshift_promotors" /id="U1774" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.647352647352647" /psig="0.647352647352647" /xcortree=1460 /SigmaFactorBS="aaagcctgggttatccaagtcaaatcagaaaagagacGGAAA CTTCggttctcttgaaCCGTATGATGAATGATaagaaaacccgtggcgggaagattca g" /listShort="aroH, S857, trpE, trpD, trpC" /listLong="trpF, trpB, trpA, hisC, tyrA, aroE" /label="promotor_-10" upshifts complement(2074361) /Source="Nicolas_upshifts" /id="U1774" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.647352647352647" /psig="0.647352647352647" /xcortree=1460 /SigmaFactorBS="aaagcctgggttatccaagtcaaatcagaaaagagacGGAAA CTTCggttctcttgaaCCGTATGATGAATGATaagaaaacccgtggcgggaagattca g" /listShort="aroH, S857, trpE, trpD, trpC" /listLong="trpF, trpB, trpA, hisC, tyrA, aroE" /label="upshifts" promotor_-35 complement(2074376..2074384) /Source="Nicolas_upshift_promotors" /id="U1774" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.647352647352647" /psig="0.647352647352647" /xcortree=1460 /SigmaFactorBS="aaagcctgggttatccaagtcaaatcagaaaagagacGGAAA CTTCggttctcttgaaCCGTATGATGAATGATaagaaaacccgtggcgggaagattca g" /listShort="aroH, S857, trpE, trpD, trpC" /listLong="trpF, trpB, trpA, hisC, tyrA, aroE" /label="promotor_-35" CDS complement(2075307..2076479) /gene="aroF" /locus_tag="BSU_22710" /old_locus_tag="BSU22710" /EC_number="4.2.3.5" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:97285, 97286, 6795181, 10518299, 24628944" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 97285, 97286, 6795181, 10518299, 24628944; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="chorismate synthase" /protein_id="NP_390152.3" /db_xref="EnsemblGenomes-Gn:BSU22710" /db_xref="EnsemblGenomes-Tr:CAB14187" /db_xref="GOA:P31104" /db_xref="InterPro:IPR000453" /db_xref="InterPro:IPR020541" /db_xref="InterPro:IPR035904" /db_xref="SubtiList:BG10284" /db_xref="UniProtKB/Swiss-Prot:P31104" /translation="MRYLTAGESHGPQLTTIIEGVPAGLYITEEDINFELARRQKGHG RGRRMQIEKDQAKIMSGVRHARTLGSPIALVVENNDWKHWTKIMGAAPITEDEEKEMK RQISRPRPGHADLNGAIKYNHRDMRNVLERSSARETTVRVAAGAVAKKILSELGIKVA GHVLQIGAVKAEKTEYTSIEDLQRVTEESPVRCYDEEAGKKMMAAIDEAKANGDSIGG IVEVIVEGMPVGVGSYVHYDRKLDSKLAAAVLSINAFKGVEFGIGFEAAGRNGSEVHD EIIWDEEKGYTRATNRLGGLEGGMTTGMPIVVRGVMKPIPTLYKPLKSVDIETKEPFS ASIERSDSCAVPAASVVAEAAVAWEIANAVVEQFGLDQIDRIRENVENMRKLSREF*" /label="aroF CDS" gene complement(2075307..2076479) /gene="aroF" /locus_tag="BSU_22710" /old_locus_tag="BSU22710" /label="aroF gene" promotor_-10 complement(2076514..2076533) /Source="Nicolas_upshift_promotors" /id="U1775" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.607392607392607" /psig="0.999000999001" /xcortree=3020 /SigmaFactorBS="tagtcccagccgatacattcttttatcaaaaaagatagACTG ACTTtttgctgaaaaaTATGTTATAGTAGTCTTACTtaaaagcgttaatgcgatgaag g" /listShort="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE" /listLong="S856, S855, ypiA, ypiB, ypiF" /label="promotor_-10" upshifts complement(2076531) /Source="Nicolas_upshifts" /id="U1775" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.607392607392607" /psig="0.999000999001" /xcortree=3020 /SigmaFactorBS="tagtcccagccgatacattcttttatcaaaaaagatagACTG ACTTtttgctgaaaaaTATGTTATAGTAGTCTTACTtaaaagcgttaatgcgatgaag g" /listShort="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE" /listLong="S856, S855, ypiA, ypiB, ypiF" /label="upshifts" promotor_-35 complement(2076546..2076553) /Source="Nicolas_upshift_promotors" /id="U1775" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.607392607392607" /psig="0.999000999001" /xcortree=3020 /SigmaFactorBS="tagtcccagccgatacattcttttatcaaaaaagatagACTG ACTTtttgctgaaaaaTATGTTATAGTAGTCTTACTtaaaagcgttaatgcgatgaag g" /listShort="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE" /listLong="S856, S855, ypiA, ypiB, ypiF" /label="promotor_-35" CDS complement(2076554..2077324) /gene="cheR" /locus_tag="BSU_22720" /old_locus_tag="BSU22720" /EC_number="2.1.1.80" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:7635819, 7893679, 8244966, 10196193, 15544802, 25799883, 27544050" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7635819, 7893679, 8244966, 10196193, 15544802, 25799883, 27544050; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methyl-accepting chemotaxis proteins (MCPs) methyltransferase" /protein_id="NP_390153.2" /db_xref="EnsemblGenomes-Gn:BSU22720" /db_xref="EnsemblGenomes-Tr:CAB14188" /db_xref="GOA:P31105" /db_xref="InterPro:IPR000780" /db_xref="InterPro:IPR022641" /db_xref="InterPro:IPR022642" /db_xref="InterPro:IPR029063" /db_xref="InterPro:IPR036804" /db_xref="PDB:5FTW" /db_xref="SubtiList:BG10283" /db_xref="UniProtKB/Swiss-Prot:P31105" /translation="MDTYSVFTTKWKQLTGVDLTLYKEAQMKRRLTSLYEKKGFQSFK DFAAALEKDQALLNETLDRMTINVSEFYRNYKRWEVLETAILPLIKTSRPLKIWSAAC STGEEPYTLAMLLDQQKGLPGYQILATDIDEKALEKAKKGVYQERSLQEVPLSVKDRY FTQNANRSYEVKTEIKKNITFKKHNLLADRYEQDFDLIVCRNVFIYFTESAKEELYLK MAHSLKKNGVLFVGSTEQIFNPEKFGLVPADTFFYQKR*" /label="cheR CDS" gene complement(2076554..2077324) /gene="cheR" /locus_tag="BSU_22720" /old_locus_tag="BSU22720" /label="cheR gene" promotor_-10 complement(2077350..2077369) /Source="Nicolas_upshift_promotors" /id="U1776" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.821178821178821" /psig=1 /xcortree=3061 /SigmaFactorBS="tctaaaatcagctgaaaagctgatttttttattgaaacaaTA CAATTtcctgataaaaCAAGCTATACTAGGACAAAAagacagcgagactgggagagta g" /listShort="cheR, aroF, aroB, aroH, S857, trpE, trpD" /listLong="trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_-10" upshifts complement(2077367) /Source="Nicolas_upshifts" /id="U1776" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.821178821178821" /psig=1 /xcortree=3061 /SigmaFactorBS="tctaaaatcagctgaaaagctgatttttttattgaaacaaTA CAATTtcctgataaaaCAAGCTATACTAGGACAAAAagacagcgagactgggagagta g" /listShort="cheR, aroF, aroB, aroH, S857, trpE, trpD" /listLong="trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="upshifts" promotor_-35 complement(2077381..2077387) /Source="Nicolas_upshift_promotors" /id="U1776" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.821178821178821" /psig=1 /xcortree=3061 /SigmaFactorBS="tctaaaatcagctgaaaagctgatttttttattgaaacaaTA CAATTtcctgataaaaCAAGCTATACTAGGACAAAAagacagcgagactgggagagta g" /listShort="cheR, aroF, aroB, aroH, S857, trpE, trpD" /listLong="trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_-35" S_feature complement(2077399..2077560) /Source="Nicolas_S_feature" /locus_tag="new_2381192_2381353_c" /HighExp="M0t90, Lbstat, S0, Mt0, M0t45, M40t90, Lbtran, Mal, G/S, MG-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="0.996, 0.999, 1, 0.998" /TUlongSig="SigEF" /TUlongPSig=1 /label="S858" downshifts complement(2077442) /Source="Nicolas_upshifts" /id="D1185" /incds=0 /nref=26 /ntot=128 /MaxReadThrough="4.04342" /MaxDrop="4.7493" /score="29.2259705" /energy="-8.6" /TU="U1777,U1778,U1779,U1780" /idTUdmin="U1778" /TUdmin="-880" /isTUend="FALSE" /label="downshifts" CDS complement(2077561..2078010) /gene="ndk" /locus_tag="BSU_22730" /old_locus_tag="BSU22730" /EC_number="2.7.4.6" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9179491, 11734624, 22720735, 26735940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nucleoside diphosphate kinase" /protein_id="NP_390154.1" /db_xref="EnsemblGenomes-Gn:BSU22730" /db_xref="EnsemblGenomes-Tr:CAB14189" /db_xref="GOA:P31103" /db_xref="InterPro:IPR001564" /db_xref="InterPro:IPR023005" /db_xref="InterPro:IPR034907" /db_xref="InterPro:IPR036850" /db_xref="SubtiList:BG10282" /db_xref="UniProtKB/Swiss-Prot:P31103" /translation="MMEKTFIMVKPDGVQRQLIGDILSRFERKGLQLAGAKLMRVTEQ MAEKHYAEHQGKPFFGELVEFITSGPVFAMVWEGENVIEVTRQLIGKTNPKEALPGTI RGDYGMFVGKNIIHGSDSLESAEREINIFFKNEELVSYQQLMAGWIY*" /label="ndk CDS" gene complement(2077561..2078010) /gene="ndk" /locus_tag="BSU_22730" /old_locus_tag="BSU22730" /label="ndk gene" promotor_-10 complement(2078053..2078072) /Source="Nicolas_upshift_promotors" /id="U1777" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.578421578421578" /psig="0.996003996003996" /xcortree=1593 /SigmaFactorBS="gtagatattaagaaatttctccgccccgGATTGATTaattat cagaaaGATGTTACGATTTCGGTGTGcagtgtgaaagcctatacatacataatgatgg g" /listShort="ndk, S858, cheR, aroF, aroB, aroH, S857" /listLong="trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE" /label="promotor_-10" upshifts complement(2078060) /Source="Nicolas_upshifts" /id="U1777" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.578421578421578" /psig="0.996003996003996" /xcortree=1593 /SigmaFactorBS="gtagatattaagaaatttctccgccccgGATTGATTaattat cagaaaGATGTTACGATTTCGGTGTGcagtgtgaaagcctatacatacataatgatgg g" /listShort="ndk, S858, cheR, aroF, aroB, aroH, S857" /listLong="trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE" /label="upshifts" promotor_-35 complement(2078085..2078092) /Source="Nicolas_upshift_promotors" /id="U1777" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.578421578421578" /psig="0.996003996003996" /xcortree=1593 /SigmaFactorBS="gtagatattaagaaatttctccgccccgGATTGATTaattat cagaaaGATGTTACGATTTCGGTGTGcagtgtgaaagcctatacatacataatgatgg g" /listShort="ndk, S858, cheR, aroF, aroB, aroH, S857" /listLong="trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE" /label="promotor_-35" CDS complement(2078126..2079172) /gene="hepT" /locus_tag="BSU_22740" /old_locus_tag="BSU22740" /EC_number="2.5.1.30" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6768722, 9139683, 9720033, 9756625, 10545188, 23840410" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6768722, 9139683, 9720033, 9756625, 10545188, 23840410; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="heptaprenyl diphosphate synthase component II" /protein_id="NP_390155.1" /db_xref="EnsemblGenomes-Gn:BSU22740" /db_xref="EnsemblGenomes-Tr:CAB14190" /db_xref="GOA:P31114" /db_xref="InterPro:IPR000092" /db_xref="InterPro:IPR008949" /db_xref="InterPro:IPR014119" /db_xref="InterPro:IPR033749" /db_xref="SubtiList:BG10281" /db_xref="UniProtKB/Swiss-Prot:P31114" /translation="MLNIIRLLAESLPRISDGNENTDVWVNDMKFKMAYSFLNDDIDV IERELEQTVRSDYPLLSEAGLHLLQAGGKRIRPVFVLLSGMFGDYDINKIKYVAVTLE MIHMASLVHDDVIDDAELRRGKPTIKAKWDNRIAMYTGDYMLAGSLEMMTRINEPKAH RILSQTIVEVCLGEIEQIKDKYNMEQNLRTYLRRIKRKTALLIAVSCQLGAIASGADE KIHKALYWFGYYVGMSYQIIDDILDFTSTEEELGKPVGGDLLQGNVTLPVLYALKNPA LKNQLKLINSETTQEQLEPIIEEIKKTDAIEASMAVSEMYLQKAFQKLNTLPRGRARS SLAAIAKYIGKRKF*" /label="hepT CDS" gene complement(2078126..2079172) /gene="hepT" /locus_tag="BSU_22740" /old_locus_tag="BSU22740" /label="hepT gene" CDS complement(2079114..2079815) /gene="menG" /locus_tag="BSU_22750" /old_locus_tag="BSU22750" /EC_number="2.1.1.163" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:16279806, 9045837, 9139683, 21513522, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16279806, 9045837, 9139683, 21513522, 26735940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="demethylmenaquinone methyltransferase" /protein_id="NP_390156.1" /db_xref="EnsemblGenomes-Gn:BSU22750" /db_xref="EnsemblGenomes-Tr:CAB14191" /db_xref="GOA:P31113" /db_xref="InterPro:IPR004033" /db_xref="InterPro:IPR014122" /db_xref="InterPro:IPR023576" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG10280" /db_xref="UniProtKB/Swiss-Prot:P31113" /translation="MQDSKEQRVHGVFEKIYKNYDQMNSVISFQQHKKWRDKTMRIMN VKEGAKALDVCCGTADWTIALAKAAGKSGEIKGLDFSENMLSVGEQKVKDGGFSQIEL LHGNAMELPFDDDTFDYVTIGFGLRNVPDYLTVLKEMRRVVKPGGQVVCLETSQPEMF GFRQAYFMYFKYIMPFFGKLFAKSYKEYSWLQESARDFPGMKELAGLFEEAGLKNVKY HSFTGGVAATHIGWK*" /label="menG CDS" gene complement(2079114..2079815) /gene="menG" /locus_tag="BSU_22750" /old_locus_tag="BSU22750" /label="menG gene" CDS complement(2079822..2080577) /gene="hepS" /locus_tag="BSU_22760" /old_locus_tag="BSU22760" /EC_number="2.5.1.30" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:6768722, 9139683, 9720033, 9756625, 10545188, 23840410" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6768722, 9139683, 9720033, 9756625, 10545188, 23840410; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="heptaprenyl diphosphate synthase component I" /protein_id="NP_390157.1" /db_xref="EnsemblGenomes-Gn:BSU22760" /db_xref="EnsemblGenomes-Tr:CAB14192" /db_xref="GOA:P31112" /db_xref="InterPro:IPR009920" /db_xref="SubtiList:BG10279" /db_xref="UniProtKB/Swiss-Prot:P31112" /translation="MQDIYGTLANLNTKLKQKLSHPYLAKHISAPKIDEDKLLLFHAL FEEADIKNNDRENYIVTAMLVQSALDTHDEVTTARVIKRDENKNRQLTVLAGDYFSGL YYSLLSEMKDIYMIRTLATAIKEINEHKIRLYDRSFKDENDFFESVGIVESALFHRVA EHFNLPRWKKLSSDFFVFKRLMNGNDAFLDVIGSFIQLGKTKEEILEDCFKKAKNSIE SLLPLNSPIQNILINRLKTISQDQTYHQKVEEG*" /label="hepS CDS" gene complement(2079822..2080577) /gene="hepS" /locus_tag="BSU_22760" /old_locus_tag="BSU22760" /label="hepS gene" S_feature complement(2080578..2080663) /Source="Nicolas_S_feature" /locus_tag="new_2384371_2384456_c" /HighExp="H2O2, G150, G180, Paraq, Oxctl, G135, T-4.40H, Lbexp, T-3.40H, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.999, 1, 0.998" /TUlongSig="SigEF" /TUlongPSig=1 /label="S859" promotor_-10 complement(2080652..2080671) /Source="Nicolas_upshift_promotors" /id="U1778" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.919080919080919" /psig="0.999000999001" /xcortree=2333 /SigmaFactorBS="ttaaaagcaaatgctcgcaaacagcgggaggataCAGCCAAT ttctttttttTATGCTATAATGATACCTGCgtaagcgaatgaaaagataaaactcata c" /listShort="S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_-10" upshifts complement(2080663) /Source="Nicolas_upshifts" /id="U1778" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.919080919080919" /psig="0.999000999001" /xcortree=2333 /SigmaFactorBS="ttaaaagcaaatgctcgcaaacagcgggaggataCAGCCAAT ttctttttttTATGCTATAATGATACCTGCgtaagcgaatgaaaagataaaactcata c" /listShort="S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="upshifts" promotor_-35 complement(2080682..2080689) /Source="Nicolas_upshift_promotors" /id="U1778" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.919080919080919" /psig="0.999000999001" /xcortree=2333 /SigmaFactorBS="ttaaaagcaaatgctcgcaaacagcgggaggataCAGCCAAT ttctttttttTATGCTATAATGATACCTGCgtaagcgaatgaaaagataaaactcata c" /listShort="S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_-35" CDS complement(2080741..2080968) /gene="mtrB" /locus_tag="BSU_22770" /old_locus_tag="BSU22770" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15099736, 15588817, 16285852, 16306262, 17114058, 28069823" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15099736, 15588817, 16285852, 16306262, 17114058, 28069823; Product type r : regulator" /codon_start=1 /transl_table=11 /product="tryptophan operon RNA-binding attenuation protein (TRAP)" /protein_id="NP_390158.1" /db_xref="EnsemblGenomes-Gn:BSU22770" /db_xref="EnsemblGenomes-Tr:CAB14193" /db_xref="GOA:P19466" /db_xref="InterPro:IPR000824" /db_xref="InterPro:IPR016031" /db_xref="InterPro:IPR023558" /db_xref="PDB:1WAP" /db_xref="PDB:3ZZQ" /db_xref="PDB:4B27" /db_xref="SubtiList:BG10278" /db_xref="UniProtKB/Swiss-Prot:P19466" /translation="MNQKHSSDFVVIKAVEDGVNVIGLTRGTDTKFHHSEKLDKGEVI IAQFTEHTSAIKVRGEALIQTAYGEMKSEKK*" /label="mtrB CDS" gene complement(2080741..2080968) /gene="mtrB" /locus_tag="BSU_22770" /old_locus_tag="BSU22770" /label="mtrB gene" downshifts complement(2080762) /Source="Nicolas_upshifts" /id="D1186" /incds=0 /nref=22 /ntot=162 /MaxReadThrough="6.02348" /MaxDrop="4.385" /score="8.50521108" /energy="-10.5" /TU="U1779,U1780" /idTUdmin="U1781" /TUdmin=1499 /isTUend="FALSE" /label="downshifts" CDS complement(2080990..2081562) /gene="folEA" /locus_tag="BSU_22780" /old_locus_tag="BSU22780" /EC_number="3.5.4.16" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1551827, 12559918, 14717702, 17032654" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1551827, 12559918, 14717702, 17032654; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="GTP cyclohydrolase I" /protein_id="NP_390159.1" /db_xref="EnsemblGenomes-Gn:BSU22780" /db_xref="EnsemblGenomes-Tr:CAB14194" /db_xref="GOA:P19465" /db_xref="InterPro:IPR001474" /db_xref="InterPro:IPR018234" /db_xref="InterPro:IPR020602" /db_xref="SubtiList:BG10277" /db_xref="UniProtKB/Swiss-Prot:P19465" /translation="MKEVNKEQIEQAVRQILEAIGEDPNREGLLDTPKRVAKMYAEVF SGLNEDPKEHFQTIFGENHEELVLVKDIAFHSMCEHHLVPFYGKAHVAYIPRGGKVTG LSKLARAVEAVAKRPQLQERITSTIAESIVETLDPHGVMVVVEAEHMCMTMRGVRKPG AKTVTSAVRGVFKDDAAARAEVLEHIKRQD*" /label="folEA CDS" gene complement(2080990..2081562) /gene="folEA" /locus_tag="BSU_22780" /old_locus_tag="BSU22780" /label="folEA gene" promotor_-10 complement(2081591..2081610) /Source="Nicolas_upshift_promotors" /id="U1779" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.841158841158841" /psig=1 /xcortree=1869 /SigmaFactorBS="aagagcatgggcttcctgacagggcattcactTTGCTTTtag cggggcataTGTGCTAGAATCGAAATTAAatgtattcattggtggaggacatagaaca t" /listShort="folEA, mtrB, S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_-10" upshifts complement(2081601) /Source="Nicolas_upshifts" /id="U1779" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.841158841158841" /psig=1 /xcortree=1869 /SigmaFactorBS="aagagcatgggcttcctgacagggcattcactTTGCTTTtag cggggcataTGTGCTAGAATCGAAATTAAatgtattcattggtggaggacatagaaca t" /listShort="folEA, mtrB, S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="upshifts" S_feature complement(2081603..2081686) /Source="Nicolas_S_feature" /locus_tag="new_2385396_2385479_c" /HighExp="Oxctl, G150, G180, G135, LBGexp, Paraq, LPh, H2O2, aero, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="SigEF" /TUlongPSig=1 /label="S860" promotor_-35 complement(2081623..2081629) /Source="Nicolas_upshift_promotors" /id="U1779" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.841158841158841" /psig=1 /xcortree=1869 /SigmaFactorBS="aagagcatgggcttcctgacagggcattcactTTGCTTTtag cggggcataTGTGCTAGAATCGAAATTAAatgtattcattggtggaggacatagaaca t" /listShort="folEA, mtrB, S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_-35" downshifts complement(2081731) /Source="Nicolas_upshifts" /id="D1187" /incds=0 /nref=33 /ntot=254 /MaxReadThrough="6.68474" /MaxDrop="5.1938" /score="8.50521108" /energy="-10.5" /TU="U1780" /idTUdmin="U1781" /TUdmin=530 /isTUend="FALSE" /label="downshifts" CDS complement(2081750..2082028) /gene="hbs" /locus_tag="BSU_22790" /old_locus_tag="BSU22790" /function="16.1: Circulate" /function="16.3: Control" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:1382620, 9106208, 10224127, 10231583, 10715001, 11931565, 19210617" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1382620, 9106208, 10224127, 10231583, 10715001, 11931565, 19210617; Product type f: factor" /codon_start=1 /transl_table=11 /product="non-specific DNA-binding protein HBsu" /protein_id="NP_390160.1" /db_xref="EnsemblGenomes-Gn:BSU22790" /db_xref="EnsemblGenomes-Tr:CAB14195" /db_xref="GOA:P08821" /db_xref="InterPro:IPR000119" /db_xref="InterPro:IPR010992" /db_xref="InterPro:IPR020816" /db_xref="SubtiList:BG10276" /db_xref="UniProtKB/Swiss-Prot:P08821" /translation="MNKTELINAVAEASELSKKDATKAVDSVFDTILDALKNGDKIQL IGFGNFEVRERSARKGRNPQTGEEIEIPASKVPAFKPGKALKDAVAGK*" /label="hbs CDS" gene complement(2081750..2082028) /gene="hbs" /locus_tag="BSU_22790" /old_locus_tag="BSU22790" /label="hbs gene" S_feature complement(2082029..2082254) /Source="Nicolas_S_feature" /locus_tag="new_2385822_2386047_c" /HighExp="dia5, C90, T-0.40H, G/S, S1, Salt, Lbexp, dia15, T-1.40H, BI" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="SigEF" /TUlongPSig=1 /label="S861" promotor_-10 complement(2082236..2082255) /Source="Nicolas_upshift_promotors" /id="U1780" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.591408591408591" /psig="0.998001998001998" /xcortree=2643 /SigmaFactorBS="aaaaaaggaatattcgttcggtaaatcaccttaaatcCTTGA CgagcaagggattgacgCTTTAAAATGCTTGATATGGctttttatatgtgttactcta c" /listShort="S861, hbs, S860, folEA, mtrB, S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_-10" upshifts complement(2082254) /Source="Nicolas_upshifts" /id="U1780" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.591408591408591" /psig="0.998001998001998" /xcortree=2643 /SigmaFactorBS="aaaaaaggaatattcgttcggtaaatcaccttaaatcCTTGA CgagcaagggattgacgCTTTAAAATGCTTGATATGGctttttatatgtgttactcta c" /listShort="S861, hbs, S860, folEA, mtrB, S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="upshifts" promotor_-35 complement(2082272..2082277) /Source="Nicolas_upshift_promotors" /id="U1780" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.591408591408591" /psig="0.998001998001998" /xcortree=2643 /SigmaFactorBS="aaaaaaggaatattcgttcggtaaatcaccttaaatcCTTGA CgagcaagggattgacgCTTTAAAATGCTTGATATGGctttttatatgtgttactcta c" /listShort="S861, hbs, S860, folEA, mtrB, S859, hepS, menH, hepT, ndk, S858, cheR" /listLong="aroF, aroB, aroH, S857, trpE, trpD, trpC, trpF, trpB, trpA, hisC, tyrA, aroE, S856, S855, ypiA, ypiB, ypiF" /label="promotor_-35" CDS complement(2082402..2083880) /gene="spoIVA" /locus_tag="BSU_22800" /old_locus_tag="BSU22800" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:11160095, 17114257, 17427285, 24810258, 26387458, 28408070" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11160095, 17114257, 17427285, 24810258, 26387458, 28408070; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="morphogenetic stage IV sporulation protein" /protein_id="NP_390161.1" /db_xref="EnsemblGenomes-Gn:BSU22800" /db_xref="EnsemblGenomes-Tr:CAB14196" /db_xref="GOA:P35149" /db_xref="InterPro:IPR014201" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10275" /db_xref="UniProtKB/Swiss-Prot:P35149" /translation="MEKVDIFKDIAERTGGDIYLGVVGAVRTGKSTFIKKFMELVVLP NISNEADRARAQDELPQSAAGKTIMTTEPKFVPNQAMSVHVSDGLDVNIRLVDCVGYT VPGAKGYEDENGPRMINTPWYEEPIPFHEAAEIGTRKVIQEHSTIGVVITTDGTIGDI ARSDYIEAEERVIEELKEVGKPFIMVINSVRPYHPETEAMRQDLSEKYDIPVLAMSVE SMRESDVLSVLREALYEFPVLEVNVNLPSWVMVLKENHWLRESYQESVKETVKDIKRL RDVDRVVGQFSEFEFIESAGLAGIELGQGVAEIDLYAPDHLYDQILKEVVGVEIRGRD HLLELMQDFAHAKTEYDQVSDALKMVKQTGYGIAAPALADMSLDEPEIIRQGSRFGVR LKAVAPSIHMIKVDVESEFAPIIGTEKQSEELVRYLMQDFEDDPLSIWNSDIFGRSLS SIVREGIQAKLSLMPENARYKLKETLERIINEGSGGLIAIIL*" /label="spoIVA CDS" gene complement(2082402..2083880) /gene="spoIVA" /locus_tag="BSU_22800" /old_locus_tag="BSU22800" /label="spoIVA gene" downshifts complement(2082415) /Source="Nicolas_upshifts" /id="D1188" /incds=0 /nref=59 /ntot=76 /MaxReadThrough="3.43222" /MaxDrop="7.13908" /score="13.6316529" /energy="-9.2" /TU="U1781" /idTUdmin="U1782" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2083881..2084042) /Source="Nicolas_S_feature" /locus_tag="new_2387674_2387835_c" /HighExp="S3, S4, S5, S6, LoTm, S7, B36, BT, T5.0H, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S862" promotor_-10 complement(2084029..2084047) /Source="Nicolas_upshift_promotors" /id="U1781" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1096 /SigmaFactorBS="gtaaatgacaaacaggaacctgtttttttagaaaatgatatg aaaaaGGAATGaacctttctcccttGCATACAAATAGGGAGAAAggtttttttatatt a" /listShort="S862, spoIVA" /listLong="S861, hbs, S860, folEA, mtrB, S859, hepS, menH, hepT, ndk, S858" /label="promotor_-10" upshifts complement(2084054) /Source="Nicolas_upshifts" /id="U1781" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1096 /SigmaFactorBS="gtaaatgacaaacaggaacctgtttttttagaaaatgatatg aaaaaGGAATGaacctttctcccttGCATACAAATAGGGAGAAAggtttttttatatt a" /listShort="S862, spoIVA" /listLong="S861, hbs, S860, folEA, mtrB, S859, hepS, menH, hepT, ndk, S858" /label="upshifts" CDS complement(2084061..2084795) /gene="yphF" /locus_tag="BSU_22810" /old_locus_tag="BSU22810" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein of unknown function" /protein_id="NP_390162.1" /db_xref="EnsemblGenomes-Gn:BSU22810" /db_xref="EnsemblGenomes-Tr:CAB14197" /db_xref="SubtiList:BG10274" /db_xref="UniProtKB/Swiss-Prot:P39911" /translation="MGKLKCAIIFAAVVFLSGCLYPNERKSSVHAIPYQDQLKQVQSA VDEFQKANGGLLPIQTKDMSTPLYQKYPIDFNRLAPRYIAEPPSTAFESGGDYQYVLV DVENDPTVKLIDLKMAEKIRDVKLRIQMYRQEHQYPPYKDVLSRDLFTLDEKKLGDGS SLTVTSPISGNSLPLMIDGDGEIYADYRTELASCLKKSKKTFKPGTEIQDMIWHETPF VPAFSVKYTVNDKQEPVFLENDMKKE*" /label="yphF CDS" gene complement(2084061..2084795) /gene="yphF" /locus_tag="BSU_22810" /old_locus_tag="BSU22810" /label="yphF gene" promotor_-35 complement(2084062..2084067) /Source="Nicolas_upshift_promotors" /id="U1781" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1096 /SigmaFactorBS="gtaaatgacaaacaggaacctgtttttttagaaaatgatatg aaaaaGGAATGaacctttctcccttGCATACAAATAGGGAGAAAggtttttttatatt a" /listShort="S862, spoIVA" /listLong="S861, hbs, S860, folEA, mtrB, S859, hepS, menH, hepT, ndk, S858" /label="promotor_-35" downshifts complement(2084087) /Source="Nicolas_upshifts" /id="D1189" /incds=0 /nref=6 /ntot=78 /MaxReadThrough="6.50932" /MaxDrop="4.759" /score="15.8109079" /energy="-12.7" /TU="U1782" /idTUdmin="U1783" /TUdmin=1100 /isTUend="FALSE" /label="downshifts" CDS complement(2084817..2085020) /gene="yphE" /locus_tag="BSU_22820" /old_locus_tag="BSU22820" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390163.1" /db_xref="EnsemblGenomes-Gn:BSU22820" /db_xref="EnsemblGenomes-Tr:CAB14198" /db_xref="GOA:P50744" /db_xref="InterPro:IPR020076" /db_xref="SubtiList:BG11444" /db_xref="UniProtKB/Swiss-Prot:P50744" /translation="MNLALMKMWFALGSMGLMFLAVASIYLSRFKCQNRFLKIAISSF AYMCMLISGIIVFVVVFSGPVNE*" /label="yphE CDS" gene complement(2084817..2085020) /gene="yphE" /locus_tag="BSU_22820" /old_locus_tag="BSU22820" /label="yphE gene" promotor_-10 complement(2085056..2085075) /Source="Nicolas_upshift_promotors" /id="U1782" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.491508491508492" /psig=1 /xcortree=3051 /SigmaFactorBS="tttgcttcagtttttttgttctatcaatggatggaaaatctG GTTGATCttttccggcgctgTATATTAAAATATAATATAAcgcttatatcttacatat c" /listShort="yphE, yphF, S862, spoIVA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2085077) /Source="Nicolas_upshifts" /id="U1782" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.491508491508492" /psig=1 /xcortree=3051 /SigmaFactorBS="tttgcttcagtttttttgttctatcaatggatggaaaatctG GTTGATCttttccggcgctgTATATTAAAATATAATATAAcgcttatatcttacatat c" /listShort="yphE, yphF, S862, spoIVA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2085089..2085096) /Source="Nicolas_upshift_promotors" /id="U1782" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.491508491508492" /psig=1 /xcortree=3051 /SigmaFactorBS="tttgcttcagtttttttgttctatcaatggatggaaaatctG GTTGATCttttccggcgctgTATATTAAAATATAATATAAcgcttatatcttacatat c" /listShort="yphE, yphF, S862, spoIVA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2085142..2085341) /Source="Nicolas_S_feature" /locus_tag="new_2388935_2389134_c" /HighExp="S7, S8, S6, C30, BT, G135, G180, Oxctl, Cold, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA, Sig-" /TUshortPSig="1, 1, 0.481" /TUlongSig="NA" /TUlongPSig="NA" /label="S863" downshifts complement(2085185) /Source="Nicolas_upshifts" /id="D1190" /incds=0 /nref=264 /ntot=295 /MaxReadThrough="2.22999" /MaxDrop="8.05743" /score="26.216597" /energy="-14.1" /TU="NA" /idTUdmin="U1783" /TUdmin=2 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2085316..2085335) /Source="Nicolas_upshift_promotors" /id="U1783" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1314 /SigmaFactorBS="agatggaggatttggtaaatacgtttgaaaatcaagtgaagt aAAAGTGTCAAtcaaatggtgaatCGCATATCTTAATTGAACGAaagcccgaaaaaca g" /listShort="S863" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2085341) /Source="Nicolas_upshifts" /id="U1783" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1314 /SigmaFactorBS="agatggaggatttggtaaatacgtttgaaaatcaagtgaagt aAAAGTGTCAAtcaaatggtgaatCGCATATCTTAATTGAACGAaagcccgaaaaaca g" /listShort="S863" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2085349..2085358) /Source="Nicolas_upshift_promotors" /id="U1783" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1314 /SigmaFactorBS="agatggaggatttggtaaatacgtttgaaaatcaagtgaagt aAAAGTGTCAAtcaaatggtgaatCGCATATCTTAATTGAACGAaagcccgaaaaaca g" /listShort="S863" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2085358..2086395) /gene="gpsA" /locus_tag="BSU_22830" /old_locus_tag="BSU22830" /EC_number="1.1.1.94" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7592341, 12682299, 15557260" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7592341, 12682299, 15557260; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADPH-dependent glycerol-3-phosphate dehydrogenase" /protein_id="NP_390164.1" /db_xref="EnsemblGenomes-Gn:BSU22830" /db_xref="EnsemblGenomes-Tr:CAB14199" /db_xref="GOA:P46919" /db_xref="InterPro:IPR006109" /db_xref="InterPro:IPR006168" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR011128" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11366" /db_xref="UniProtKB/Swiss-Prot:P46919" /translation="MKKVTMLGAGSWGTALALVLTDNGNEVCVWAHRADLIHQINELH ENKDYLPNVKLSTSIKGTTDMKEAVSDADVIIVAVPTKAIREVLRQAVPFITKKAVFV HVSKGIEPDSLLRISEIMEIELPSDVRKDIVVLSGPSHAEEVGLRHPTTVTASSKSMR AAEEVQDLFINHNFRVYTNPDIIGVEIGGALKNIIALAAGITDGLGYGDNAKAALITR GLAEIARLGTKMGGNPLTFSGLTGVGDLIVTCTSVHSRNWRAGNLLGKGYKLEDVLEE MGMVVEGVRTTKAAYQLSKKYDVKMPITEALHQVLFNGQKVETAVESLMARGKTHEME DLVNTFENQVK*" /label="gpsA CDS" gene complement(2085358..2086395) /gene="gpsA" /locus_tag="BSU_22830" /old_locus_tag="BSU22830" /label="gpsA gene" CDS complement(2086413..2087723) /gene="der" /locus_tag="BSU_22840" /old_locus_tag="BSU22840" /EC_number="3.6.5.-" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 16682769, 16894162, 16997968, 19246542, 23056455, 24822275, 27484475" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16682769, 16894162, 16997968, 19246542, 23056455, 24822275, 27484475; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="GTPase essential for ribosome 50S subunit assembly (maturation of the 50S subunit central protoberance)" /protein_id="NP_390165.1" /db_xref="EnsemblGenomes-Gn:BSU22840" /db_xref="EnsemblGenomes-Tr:CAB14200" /db_xref="GOA:P50743" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR016484" /db_xref="InterPro:IPR027368" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031166" /db_xref="InterPro:IPR032859" /db_xref="PDB:2HJG" /db_xref="PDB:4DCS" /db_xref="PDB:4DCT" /db_xref="PDB:4DCU" /db_xref="PDB:4DCV" /db_xref="PDB:4KYU" /db_xref="PDB:5X4B" /db_xref="SubtiList:BG11443" /db_xref="UniProtKB/Swiss-Prot:P50743" /translation="MGKPVVAIVGRPNVGKSTIFNRIAGERISIVEDTPGVTRDRIYS SAEWLNYDFNLIDTGGIDIGDEPFLAQIRQQAEIAMDEADVIIFMVNGREGVTAADEE VAKILYRTKKPVVLAVNKLDNTEMRANIYDFYSLGFGEPYPISGTHGLGLGDLLDAVA EHFKNIPETKYNEEVIQFCLIGRPNVGKSSLVNAMLGEERVIVSNVAGTTRDAVDTSF TYNQQEFVIVDTAGMRKKGKVYETTEKYSVLRALKAIDRSEVVAVVLDGEEGIIEQDK RIAGYAHEAGKAVVIVVNKWDAVDKDESTMKEFEENIRDHFQFLDYAPILFMSALTKK RIHTLMPAIIKASENHSLRVQTNVLNDVIMDAVAMNPTPTHNGSRLKIYYATQVSVKP PSFVVFVNDPELMHFSYERFLENRIRDAFGFEGTPIKIFARARK*" /label="der CDS" gene complement(2086413..2087723) /gene="der" /locus_tag="BSU_22840" /old_locus_tag="BSU22840" /label="der gene" S_feature complement(2087724..2087848) /Source="Nicolas_S_feature" /locus_tag="new_2391517_2391641_c" /HighExp="Cold, G180, G150, Oxctl, G135, C30, LBGexp, Paraq, dia0, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="1, 0.481" /TUlongSig="NA" /TUlongPSig="NA" /label="S864" promotor_-10 complement(2087834..2087853) /Source="Nicolas_upshift_promotors" /id="U1784" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.706293706293706" /psig=1 /xcortree=2499 /SigmaFactorBS="atgacgtgtatttgatcgtgaaacatttttaagaataGTTGt gatcccagtaaaaACTGATATAATAAATGAGTTaagcccttcctctgaagggtttctt t" /listShort="S864, engA, gpsA, S863" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2087848) /Source="Nicolas_upshifts" /id="U1784" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.706293706293706" /psig=1 /xcortree=2499 /SigmaFactorBS="atgacgtgtatttgatcgtgaaacatttttaagaataGTTGt gatcccagtaaaaACTGATATAATAAATGAGTTaagcccttcctctgaagggtttctt t" /listShort="S864, engA, gpsA, S863" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2087868..2087871) /Source="Nicolas_upshift_promotors" /id="U1784" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.706293706293706" /psig=1 /xcortree=2499 /SigmaFactorBS="atgacgtgtatttgatcgtgaaacatttttaagaataGTTGt gatcccagtaaaaACTGATATAATAAATGAGTTaagcccttcctctgaagggtttctt t" /listShort="S864, engA, gpsA, S863" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2087877..2088071) /gene="ypzH" /locus_tag="BSU_22849" /old_locus_tag="BSU22849" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097755.1" /db_xref="EnsemblGenomes-Gn:BSU22849" /db_xref="EnsemblGenomes-Tr:CAX52654" /db_xref="UniProtKB/Swiss-Prot:C0H445" /translation="MSESLTKVILSVITTNRNRVAGGAPVFFCNDQKEMELFAKNLEA ILDGIAHRIGDDVYLIVKHF*" /label="ypzH CDS" gene complement(2087877..2088071) /gene="ypzH" /locus_tag="BSU_22849" /old_locus_tag="BSU22849" /label="ypzH gene" CDS complement(2088068..2088961) /gene="yphB" /locus_tag="BSU_22850" /old_locus_tag="BSU22850" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="NP_390166.1" /db_xref="EnsemblGenomes-Gn:BSU22850" /db_xref="EnsemblGenomes-Tr:CAB14201" /db_xref="GOA:P50742" /db_xref="InterPro:IPR025918" /db_xref="SubtiList:BG11442" /db_xref="UniProtKB/Swiss-Prot:P50742" /translation="MSDYIYPIIAGVIAGIATRLYMLKTDYRQYPTYVHGKVIHIALG LIAAGLGAIIMPALLQEEFTAITFLTLAATQFRDVRNMERNTLTQMDSYELVSRGSTY IEGIAIAFESRNYIVIFTALLTTSAYVFLSIWAAVIAAVVCFLLAMKFMSGSVLKDIV DIEYIKPRFDGPGLFVDNIYMMNIGLPEKQELILKHGMGFILTPKNFNSAATIANLGQ RQAILFDVSNVLGVYRDSGEPSLTPIAKRDLNDGRVAVFVLPQIHHPETAVQIISNVP TLENAIRMPTEFIKNQDKVIG*" /label="yphB CDS" gene complement(2088068..2088961) /gene="yphB" /locus_tag="BSU_22850" /old_locus_tag="BSU22850" /label="yphB gene" CDS complement(2088958..2089557) /gene="yphA" /locus_tag="BSU_22860" /old_locus_tag="BSU22860" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406; Product type m:membrane component" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="NP_390167.1" /db_xref="EnsemblGenomes-Gn:BSU22860" /db_xref="EnsemblGenomes-Tr:CAB14202" /db_xref="GOA:P50741" /db_xref="InterPro:IPR014617" /db_xref="SubtiList:BG11441" /db_xref="UniProtKB/Swiss-Prot:P50741" /translation="MEQFYYYWSMWFLWVLTTFIFEKTKRRIAVSVFILTNIILSIHD IALYFSLNAAYLMFFVCGCVYAGYLGMYRFRYIMVYLTLVAAYAFVYLFALYDPVWFI IKPEWAAVILIVLLTASVERNFEKQLVLFVLGMCQGELVYSFVIQKLAGAMAVGGFQW LNACSAGMILLFGISKYEHLASQIGQKSKRSNKGATKMS*" /label="yphA CDS" gene complement(2088958..2089557) /gene="yphA" /locus_tag="BSU_22860" /old_locus_tag="BSU22860" /label="yphA gene" promotor_-35 2089430..2089436 /Source="Nicolas_upshift_promotors" /id="U1785" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.6003996003996" /psig="0.6003996003996" /xcortree=787 /SigmaFactorBS="catcaaatatgcagcattcagggaaaaatataaagcgatgtc aTGTATGCttagaataatattAGTTAAAATAAAgacagagacggcaattcgtcttttc g" /listShort="S865, ypzI" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2089445..2089628 /Source="Nicolas_S_feature" /locus_tag="new_2393238_2393421" /HighExp="S5, S8, S6, S7, BT, S4, ferm, nit, Pyr, G/S" /AntisenseName="yphA" /AntisenseCor="0.73324773408178501" /AntisenseRegPval="-45.9" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.6" /TUlongSig="NA" /TUlongPSig="NA" /label="S865" upshifts 2089447 /Source="Nicolas_upshifts" /id="U1785" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.6003996003996" /psig="0.6003996003996" /xcortree=787 /SigmaFactorBS="catcaaatatgcagcattcagggaaaaatataaagcgatgtc aTGTATGCttagaataatattAGTTAAAATAAAgacagagacggcaattcgtcttttc g" /listShort="S865, ypzI" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2089450..2089461 /Source="Nicolas_upshift_promotors" /id="U1785" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.6003996003996" /psig="0.6003996003996" /xcortree=787 /SigmaFactorBS="catcaaatatgcagcattcagggaaaaatataaagcgatgtc aTGTATGCttagaataatattAGTTAAAATAAAgacagagacggcaattcgtcttttc g" /listShort="S865, ypzI" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2089568..2089586) /Source="Nicolas_upshift_promotors" /id="U1786" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.48051948051948" /psig="0.48051948051948" /xcortree=969 /SigmaFactorBS="tgtcttttcccatgatcatactccttaatgtgagatcgatTG TTTAaaaaatgtgcttgaaCTCCATACTGGGAATATGGaggaagtaaaatggaacaat t" /listShort="yphA, seaA, ypzH, S864, engA, gpsA, S863" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2089587) /Source="Nicolas_upshifts" /id="U1786" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.48051948051948" /psig="0.48051948051948" /xcortree=969 /SigmaFactorBS="tgtcttttcccatgatcatactccttaatgtgagatcgatTG TTTAaaaaatgtgcttgaaCTCCATACTGGGAATATGGaggaagtaaaatggaacaat t" /listShort="yphA, seaA, ypzH, S864, engA, gpsA, S863" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2089602..2089607) /Source="Nicolas_upshift_promotors" /id="U1786" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.48051948051948" /psig="0.48051948051948" /xcortree=969 /SigmaFactorBS="tgtcttttcccatgatcatactccttaatgtgagatcgatTG TTTAaaaaatgtgcttgaaCTCCATACTGGGAATATGGaggaagtaaaatggaacaat t" /listShort="yphA, seaA, ypzH, S864, engA, gpsA, S863" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2089635..2089766 /gene="ypzI" /locus_tag="BSU_22869" /old_locus_tag="BSU22869" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences" /codon_start=1 /transl_table=11 /product="putative sporulation-related protein" /protein_id="YP_003097756.2" /db_xref="EnsemblGenomes-Gn:BSU22869" /db_xref="EnsemblGenomes-Tr:CAX52655" /db_xref="InterPro:IPR025414" /db_xref="UniProtKB/Swiss-Prot:C0H446" /translation="MGKDRQEKKLKASGRVESDRDQSIHYDGATSLEQNGRFKKRKS* " /label="ypzI CDS" gene 2089635..2089766 /gene="ypzI" /locus_tag="BSU_22869" /old_locus_tag="BSU22869" /label="ypzI gene" downshifts 2089754 /Source="Nicolas_upshifts" /id="D1191" /incds=0 /nref=37 /ntot=122 /MaxReadThrough="0.20384" /MaxDrop="6.94664" /score="3.33160455" /energy="-13.2" /TU="NA" /idTUdmin="U1785" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(2089809..2090858) /gene="fni" /locus_tag="BSU_22870" /old_locus_tag="BSU22870" /EC_number="5.3.3.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12798687, 14745175, 15206931" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12798687, 14745175, 15206931; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isopentenyl diphosphate isomerase (typeII)" /protein_id="NP_390168.3" /db_xref="EnsemblGenomes-Gn:BSU22870" /db_xref="EnsemblGenomes-Tr:CAB14203" /db_xref="GOA:P50740" /db_xref="InterPro:IPR000262" /db_xref="InterPro:IPR011179" /db_xref="InterPro:IPR013785" /db_xref="PDB:1P0K" /db_xref="PDB:1P0N" /db_xref="SubtiList:BG11440" /db_xref="UniProtKB/Swiss-Prot:P50740" /translation="MTRAERKRQHINHALSIGQKRETGLDDITFVHVSLPDLALEQVD ISTKIGELSSSSPIFINAMTGGGGKLTYEINKSLARAASQAGIPLAVGSQMSALKDPS ERLSYEIVRKENPNGLIFANLGSEATAAQAKEAVEMIGANALQIHLNVIQEIVMPEGD RSFSGALKRIEQICSRVSVPVIVKEVGFGMSKASAGKLYEAGAAAVDIGGYGGTNFSK IENLRRQRQISFFNSWGISTAASLAEIRSEFPASTMIASGGLQDALDVAKAIALGASC TGMAGHFLKALTDSGEEGLLEEIQLILEELKLIMTVLGARTIADLQKAPLVIKGETHH WLTERGVNTSSYSVR*" /label="fni CDS" gene complement(2089809..2090858) /gene="fni" /locus_tag="BSU_22870" /old_locus_tag="BSU22870" /label="fni gene" downshifts complement(2089829) /Source="Nicolas_upshifts" /id="D1192" /incds=0 /nref=209 /ntot=250 /MaxReadThrough="1.39069" /MaxDrop="4.82362" /score="15.2467448" /energy="-13.2" /TU="NA" /idTUdmin="U1788" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(2090733) /Source="Nicolas_upshifts" /id="D1193" /incds=1 /nref=45 /ntot=237 /MaxReadThrough="6.15611" /MaxDrop="4.91722" /score="13.2731686" /energy="-15.7" /TU="U1788,U1789,U1790" /idTUdmin="U1788" /TUdmin="-904" /isTUend="FALSE" /label="downshifts" CDS complement(2090871..2092019) /gene="rpfA" /locus_tag="BSU_22880" /old_locus_tag="BSU22880" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9179491, 9862121, 14586115; Product type f: factor" /codon_start=1 /transl_table=11 /product="RNA degradation presenting factor (ribosomal protein S1 homolog)" /protein_id="NP_390169.1" /db_xref="EnsemblGenomes-Gn:BSU22880" /db_xref="EnsemblGenomes-Tr:CAB14204" /db_xref="GOA:P38494" /db_xref="InterPro:IPR003029" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR022967" /db_xref="SubtiList:BG11005" /db_xref="UniProtKB/Swiss-Prot:P38494" /translation="MTEEMNQIDVQVPEVGDVVKGIVTKVEDKHVDVEIINVKQSGII PISELSSLHVEKASDVVKVDDELDLKVTKVEDDALILSKRAVDADRAWEDLEKKFETK EVFEAEVKDVVKGGLVVDIGVRGFIPASLVEAHFVEDFTDYKGKTLSLLVVELDRDKN RVILSHRAVVESEQANKKQELLQSLEVGSVLDGKVQRLTDFGAFVDIGGIDGLVHISQ LSHSHVEKPSDVVEEGQEVKVKVLSVDRDNERISLSIKDTLPGPWNQIGEKVKPGDVL EGTVQRLVSFGAFVEILPGVEGLVHISQISNKHIGTPHEVLEEGQTVKVKVLDVNENE ERISLSMRELEETPKADQEDYRQYQAKEETSTGFQLGDLIGDKLNKLK*" /label="rpfA CDS" gene complement(2090871..2092019) /gene="rpfA" /locus_tag="BSU_22880" /old_locus_tag="BSU22880" /label="rpfA gene" misc_feature 2091200..2091203 /Source="Nicolas_upshift_promotors" /id="U1787" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.677322677322677" /psig="0.023976023976024" /xcortree=89 /SigmaFactorBS="ttacaagacgctgtacagttccttcaagcacatCGCCaggct tcactttttcgccgatttggttccaaggtccaggcagtgtatctttgatcgataaaga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2091227 /Source="Nicolas_upshifts" /id="U1787" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.677322677322677" /psig="0.023976023976024" /xcortree=89 /SigmaFactorBS="ttacaagacgctgtacagttccttcaagcacatCGCCaggct tcactttttcgccgatttggttccaaggtccaggcagtgtatctttgatcgataaaga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2091293 /Source="Nicolas_upshifts" /id="D1194" /incds=1 /nref=1 /ntot=124 /MaxReadThrough="1.88188" /MaxDrop="2.8624" /score="-3.97389972" /energy="-11.8" /TU="NA" /idTUdmin="U1787" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 2091997 /Source="Nicolas_upshifts" /id="D1195" /incds=0 /nref=3 /ntot=200 /MaxReadThrough="1.33117" /MaxDrop="3.08345" /score="-3.97389972" /energy="-11.8" /TU="NA" /idTUdmin="U1787" /TUdmin=704 /isTUend="FALSE" /label="downshifts" S_feature complement(2092020..2092159) /Source="Nicolas_S_feature" /locus_tag="new_2395813_2395952_c" /HighExp="C90, Salt, Etha, Lbtran, HiOs, M40t90, S1, LBGtran, LoTm, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF, SigA" /TUshortPSig="0.999, 0.703, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S866" promotor_-10 complement(2092158..2092177) /Source="Nicolas_upshift_promotors" /id="U1788" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.802197802197802" /psig="0.999000999001" /xcortree=2236 /SigmaFactorBS="aacgaagatagaatgttattGCTTGACAaacctgtcctttta TTAGAAGTTAATACTAATAAaactttttattgatcattcaaaaaacttttttggatga t" /listShort="S866, ypfD, fni" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2092159) /Source="Nicolas_upshifts" /id="U1788" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.802197802197802" /psig="0.999000999001" /xcortree=2236 /SigmaFactorBS="aacgaagatagaatgttattGCTTGACAaacctgtcctttta TTAGAAGTTAATACTAATAAaactttttattgatcattcaaaaaacttttttggatga t" /listShort="S866, ypfD, fni" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2092161..2092251) /Source="Nicolas_S_feature" /locus_tag="new_2395954_2396044_c" /HighExp="G135, G180, LBGexp, C30, Cold, Oxctl, dia0, G150, Paraq, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.40511799999999998" /TUshortSig="SigEF, SigA" /TUshortPSig="0.703, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S867" promotor_-35 complement(2092192..2092199) /Source="Nicolas_upshift_promotors" /id="U1788" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.802197802197802" /psig="0.999000999001" /xcortree=2236 /SigmaFactorBS="aacgaagatagaatgttattGCTTGACAaacctgtcctttta TTAGAAGTTAATACTAATAAaactttttattgatcattcaaaaaacttttttggatga t" /listShort="S866, ypfD, fni" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2092252..2092926) /gene="cmk" /locus_tag="BSU_22890" /old_locus_tag="BSU22890" /EC_number="2.7.4.25" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8576266, 9179491, 9862121, 11827479, 12682299, 16880539" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8576266, 9179491, 9862121, 11827479, 12682299, 16880539; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cytidylate kinase" /protein_id="NP_390170.1" /db_xref="EnsemblGenomes-Gn:BSU22890" /db_xref="EnsemblGenomes-Tr:CAB14205" /db_xref="GOA:P38493" /db_xref="InterPro:IPR003136" /db_xref="InterPro:IPR011994" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11004" /db_xref="UniProtKB/Swiss-Prot:P38493" /translation="MEKKLSIAIDGPAAAGKSTVAKIVAEKKSYIYIDTGAMYRAITY AALQENVDLTDEEKLAELLKRTDIELITTKDGQKVFVNGTDVTEAIRTDEISNQVSIA AKHRSVREEMVKRQQQLGEKGGVVMDGRDIGTHVLPNAEVKIFLLASVEERAKRRYEE NVKKGFDVNYETLIEEIARRDKLDSEREVSPLRKAEDALEIDTTSLSIQEVADKILEA VEQKSR*" /label="cmk CDS" gene complement(2092252..2092926) /gene="cmk" /locus_tag="BSU_22890" /old_locus_tag="BSU22890" /label="cmk gene" S_feature complement(2092927..2093004) /Source="Nicolas_S_feature" /locus_tag="new_2396720_2396797_c" /HighExp="S4, S5, S7, S8, S6, dia15, S3, Diami, dia5, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="0.703, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S868" CDS complement(2093005..2093181) /gene="ypfB" /locus_tag="BSU_22900" /old_locus_tag="BSU22900" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_390171.1" /db_xref="EnsemblGenomes-Gn:BSU22900" /db_xref="EnsemblGenomes-Tr:CAB14206" /db_xref="InterPro:IPR035281" /db_xref="SubtiList:BG11003" /db_xref="UniProtKB/Swiss-Prot:P38492" /translation="MKTFERLLIKLLFIQAIILLGVQFLFHYQHIEPYVSKVIQYEGV DKMEENNRIETFKH*" /label="ypfB CDS" gene complement(2093005..2093181) /gene="ypfB" /locus_tag="BSU_22900" /old_locus_tag="BSU22900" /label="ypfB gene" promotor_-10 complement(2093193..2093211) /Source="Nicolas_upshift_promotors" /id="U1789" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.703296703296703" /psig="0.703296703296703" /xcortree=1196 /SigmaFactorBS="atcaggcgccagttaaataagagaagaaaggcccgaatGGAA TAAacatcggcaaacacTTCCATACTATTTGTAATGgaggtgctccaatgaaaacatt t" /listShort="ypfB, S868, cmk, S867, S866, ypfD, fni" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2093210) /Source="Nicolas_upshifts" /id="U1789" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.703296703296703" /psig="0.703296703296703" /xcortree=1196 /SigmaFactorBS="atcaggcgccagttaaataagagaagaaaggcccgaatGGAA TAAacatcggcaaacacTTCCATACTATTTGTAATGgaggtgctccaatgaaaacatt t" /listShort="ypfB, S868, cmk, S867, S866, ypfD, fni" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2093226..2093232) /Source="Nicolas_upshift_promotors" /id="U1789" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.703296703296703" /psig="0.703296703296703" /xcortree=1196 /SigmaFactorBS="atcaggcgccagttaaataagagaagaaaggcccgaatGGAA TAAacatcggcaaacacTTCCATACTATTTGTAATGgaggtgctccaatgaaaacatt t" /listShort="ypfB, S868, cmk, S867, S866, ypfD, fni" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2093226..2093879) /gene="dgrA" /locus_tag="BSU_22910" /old_locus_tag="BSU22910" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16249258, 23893111, 28536559" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16249258, 23893111, 28536559; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="cyclic di-GMP receptor" /protein_id="NP_390172.1" /db_xref="EnsemblGenomes-Gn:BSU22910" /db_xref="EnsemblGenomes-Tr:CAB14207" /db_xref="GOA:P38491" /db_xref="InterPro:IPR009875" /db_xref="InterPro:IPR009926" /db_xref="InterPro:IPR012349" /db_xref="SubtiList:BG11002" /db_xref="UniProtKB/Swiss-Prot:P38491" /translation="MIEIGENVLLEYIEENELKKAKSKAVSIENNELLIAYPVDVVTG RTVILHNDMEVTVEFVGKDEVPYRFISRIKGKVKDKLQMICLEMPPREKMKRIQRRQY VRTDAVLDVQIQPGNEEEIRTLSYNISAGGIAVVLADGLSFQSGESLRLIIRLPEEEH TRQIETEAVVRRIFNDPKSEKRKMTLEYSEIAAGDQQALLQYCIRRQLNKRRKARME* " /label="dgrA CDS" gene complement(2093226..2093879) /gene="dgrA" /locus_tag="BSU_22910" /old_locus_tag="BSU22910" /label="dgrA gene" promotor_-10 complement(2093909..2093928) /Source="Nicolas_upshift_promotors" /id="U1790" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2544 /SigmaFactorBS="aagacctataaaaacaggaggaaaggactaaatgTCTTTtcc tttttttcattaCGTGCTTTAATAAAAACGTGagtatattgaatgcgaaagagtgaag t" /listShort="ypfA, ypfB, S868, cmk, S867, S866, ypfD, fni" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2093922) /Source="Nicolas_upshifts" /id="U1790" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2544 /SigmaFactorBS="aagacctataaaaacaggaggaaaggactaaatgTCTTTtcc tttttttcattaCGTGCTTTAATAAAAACGTGagtatattgaatgcgaaagagtgaag t" /listShort="ypfA, ypfB, S868, cmk, S867, S866, ypfD, fni" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2093944..2093948) /Source="Nicolas_upshift_promotors" /id="U1790" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=2544 /SigmaFactorBS="aagacctataaaaacaggaggaaaggactaaatgTCTTTtcc tttttttcattaCGTGCTTTAATAAAAACGTGagtatattgaatgcgaaagagtgaag t" /listShort="ypfA, ypfB, S868, cmk, S867, S866, ypfD, fni" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2093972..2095324) /gene="sleC" /locus_tag="BSU_22920" /old_locus_tag="BSU22920" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10658652, 12177332, 22720735, 23543708, 24752279, 25022853, 25384476, 26187959" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10658652, 12177332, 22720735, 23543708, 24752279, 25022853, 25384476, 26187959; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination membrane component" /protein_id="NP_390173.1" /db_xref="EnsemblGenomes-Gn:BSU22920" /db_xref="EnsemblGenomes-Tr:CAB14208" /db_xref="GOA:P38490" /db_xref="InterPro:IPR014239" /db_xref="InterPro:IPR025711" /db_xref="SubtiList:BG11001" /db_xref="UniProtKB/Swiss-Prot:P38490" /translation="MIRGILIAVLGIAIVGTGYWGYKEHQEKDAVLLHAENNYQRAFH ELTYQVDQLHDKIGTTLAMNSQKSLSPALIDVWRITSEAHNSVSQLPLTLMPFNKTEE LLSKIGDFSYKTSVRDLDQKPLDKNEYTSLNKLYQQSEDIQNELRHVQHLVMSKNLRW MDVEMALASDEKQSDNTIINSFKTVEKNVGAFSTGTDLGPSFTSTKKEEKGFSHLKGK QISEQEAKQIAERFAPDDNYSIKVVKSGKKTNRDVYSISMKDPDHKAVIYMDITKKGG HPVYLIQNREVKDQKISLNDGSNRALAFLKKNGFETDDLEIDESAQYDKIGVFSYVPV ENKVRMYPEAIRMKVALDDGEVVGFSARDFLTSHRKRTIPKPAITEAEAKSKLNKNVQ VRETRLALITNELGQEVLCYEMLGTIENDTFRMYINAKDGSEEKVEKLKNAEPIYKDL *" /label="sleC CDS" gene complement(2093972..2095324) /gene="sleC" /locus_tag="BSU_22920" /old_locus_tag="BSU22920" /label="sleC gene" downshifts complement(2093987) /Source="Nicolas_upshifts" /id="D1196" /incds=0 /nref=21 /ntot=44 /MaxReadThrough="0.647060000000002" /MaxDrop="5.74199" /score="16.6521528" /energy="-10.1" /TU="NA" /idTUdmin="U1791" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2095359..2096276) /gene="sleB" /locus_tag="BSU_22930" /old_locus_tag="BSU22930" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10658652, 12177332, 16905870, 16907803, 25963559, 26187959, 28333204" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10658652, 12177332, 16905870, 16907803, 25963559, 26187959, 28333204; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination cortex-lytic enzyme" /protein_id="NP_390174.1" /db_xref="EnsemblGenomes-Gn:BSU22930" /db_xref="EnsemblGenomes-Tr:CAB14209" /db_xref="GOA:P50739" /db_xref="InterPro:IPR002477" /db_xref="InterPro:IPR011105" /db_xref="InterPro:IPR014224" /db_xref="InterPro:IPR036365" /db_xref="InterPro:IPR036366" /db_xref="SubtiList:BG11439" /db_xref="UniProtKB/Swiss-Prot:P50739" /translation="MKSKGSIMACLILFSFTITTFINTETISAFSNQVIQRGATGDDV VELQARLQYNGYYNGKIDGVYGWGTYWAVRNFQDQFGLKEVDGLVGAKTKQTLICKSK YYREYVMEQLNKGNTFTHYGKIPLKYQTKPSKAATQKARQQAEARQKQPAEKTTQKPK ANANKQQNNTPAKARKQDAVAANMPGGFSNNDIRLLAQAVYGEARGEPYEGQVAIAAV ILNRLNSPLFPNSVAGVIFEPLAFTAVADGQIYMQPNETAREAVLDAINGWDPSEEAL YYFNPDTATSPWIWGRPQIKRIGKHIFCE*" /label="sleB CDS" gene complement(2095359..2096276) /gene="sleB" /locus_tag="BSU_22930" /old_locus_tag="BSU22930" /label="sleB gene" downshifts complement(2095747) /Source="Nicolas_upshifts" /id="D1197" /incds=1 /nref=1 /ntot=3 /MaxReadThrough="6.35344" /MaxDrop="4.29326" /score="-3.16364421" /energy="-21.7" /TU="U1791,U1792" /idTUdmin="U1793" /TUdmin=682 /isTUend="FALSE" /label="downshifts" misc_feature complement(2095898..2095905) /Source="Nicolas_upshift_promotors" /id="U1791" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.245754245754246" /psig="0.374625374625375" /xcortree=1472 /SigmaFactorBS="gaatatgtcatggaacagctcaataaagggaatacattcacg cattacggaaaaatTCCGCTAAagtatcagacgaaaccatcaaaagcagcaacacaaa a" /listShort="ypeB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2095901) /Source="Nicolas_upshifts" /id="U1791" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.245754245754246" /psig="0.374625374625375" /xcortree=1472 /SigmaFactorBS="gaatatgtcatggaacagctcaataaagggaatacattcacg cattacggaaaaatTCCGCTAAagtatcagacgaaaccatcaaaagcagcaacacaaa a" /listShort="ypeB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2096314..2096325) /Source="Nicolas_upshift_promotors" /id="U1792" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=937 /SigmaFactorBS="gtgcagtttttatgttctgagggataacaaggaaagagTGTA TAAaaataacctcgttACAGAAAATACGattacacttaaaaatttgcagtaggaggct t" /listShort="sleB, ypeB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2096323) /Source="Nicolas_upshifts" /id="U1792" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=937 /SigmaFactorBS="gtgcagtttttatgttctgagggataacaaggaaagagTGTA TAAaaataacctcgttACAGAAAATACGattacacttaaaaatttgcagtaggaggct t" /listShort="sleB, ypeB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2096339..2096345) /Source="Nicolas_upshift_promotors" /id="U1792" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=937 /SigmaFactorBS="gtgcagtttttatgttctgagggataacaaggaaagagTGTA TAAaaataacctcgttACAGAAAATACGattacacttaaaaatttgcagtaggaggct t" /listShort="sleB, ypeB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2096415..2097071) /gene="prsW" /locus_tag="BSU_22940" /old_locus_tag="BSU22940" /EC_number="3.4.-.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15849754, 16816000, 16850406, 17020587, 19889088, 23155385, 28674070" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16816000, 16850406, 17020587, 19889088, 23155385, 28674070; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protease required for RsiW anti-sigma(W) degradation" /protein_id="NP_390175.1" /db_xref="EnsemblGenomes-Gn:BSU22940" /db_xref="EnsemblGenomes-Tr:CAB14210" /db_xref="GOA:P50738" /db_xref="InterPro:IPR023596" /db_xref="InterPro:IPR026898" /db_xref="SubtiList:BG11438" /db_xref="UniProtKB/Swiss-Prot:P50738" /translation="MFAIISAGIAPGIALLSYFYLKDQYDNEPVHMVLRSFFLGVVLV FPIMFIQYVLEKENVGGGSFFVSFLSSGFLEESLKWFILMISVYPHAHFDEHYDGIVY GASVSLGFATLENILYLIGHGVEHAFVRALLPVSCHALIGVIMGFYLGKARFSADKAR VKWLTLSLVVPSLLHGSYDFILTALSNWIYYMLPFMVFLWWFGLRKAKKARSVNMMQV *" /label="prsW CDS" gene complement(2096415..2097071) /gene="prsW" /locus_tag="BSU_22940" /old_locus_tag="BSU22940" /label="prsW gene" downshifts complement(2096429) /Source="Nicolas_upshifts" /id="D1198" /incds=0 /nref=239 /ntot=262 /MaxReadThrough="0.9181" /MaxDrop="6.61797" /score="-3.16364421" /energy="-21.7" /TU="NA" /idTUdmin="U1793" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(2097096..2097115) /Source="Nicolas_upshift_promotors" /id="U1793" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig=1 /xcortree=3121 /SigmaFactorBS="cattcgtatgctctttttgtttttttaagtgcagacagatgt aaaattttaaacaaCATGGTAGGATAGATGTAGGaatataaaggaaagaggttgcctg a" /listShort="prsW" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2097111) /Source="Nicolas_upshifts" /id="U1793" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig=1 /xcortree=3121 /SigmaFactorBS="cattcgtatgctctttttgtttttttaagtgcagacagatgt aaaattttaaacaaCATGGTAGGATAGATGTAGGaatataaaggaaagaggttgcctg a" /listShort="prsW" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2097191..2098165) /gene="ypdA" /locus_tag="BSU_22950" /old_locus_tag="BSU22950" /EC_number="1.8.-.-" /function="16.6: Maintain" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20308541; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative bacillithiol biosynthesis thiol disulfide oxidoreductase" /protein_id="NP_390176.2" /db_xref="EnsemblGenomes-Gn:BSU22950" /db_xref="EnsemblGenomes-Tr:CAB14211" /db_xref="GOA:P50736" /db_xref="InterPro:IPR000103" /db_xref="InterPro:IPR023856" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG11436" /db_xref="UniProtKB/Swiss-Prot:P50736" /translation="MIQEKAIIIGGGPCGLSAAIHLKQIGIDALVIEKGNVVNSIYNY PTHQTFFSSSEKLEIGDVAFITENRKPVRIQALSYYREVVKRKNIRVNAFEMVRKVTK TQNNTFVIETSKETYTTPYCIIATGYYDHPNYMGVPGEDLPKVFHYFKEGHPYFDKDV VVIGGKNSSVDAALELVKSGARVTVLYRGNEYSPSIKPWILPEFEALVRNGTIRMEFG ACVEKITENEVVFRSGEKELITIKNDFVFAMTGYHPDHQFLEKIGVEIDKETGRPFFN EETMETNVEGVFIAGVIAAGNNANEIFIENGRFHGGHIAAEIAKRENH*" /label="ypdA CDS" gene complement(2097191..2098165) /gene="ypdA" /locus_tag="BSU_22950" /old_locus_tag="BSU22950" /label="ypdA gene" downshifts complement(2097199) /Source="Nicolas_upshifts" /id="D1199" /incds=0 /nref=239 /ntot=263 /MaxReadThrough="3.524" /MaxDrop="6.45954" /score="27.4058676" /energy="-12.2" /TU="U1796" /idTUdmin="U1796" /TUdmin="-748" /isTUend="FALSE" /label="downshifts" promotor_-35 2098019..2098024 /Source="Nicolas_upshift_promotors" /id="U1794" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.958041958041958" /psig="0.958041958041958" /xcortree=1114 /SigmaFactorBS="atttcgagcttttcacttgaactgaaaaaGGTTTGatgcgtc gggtaattGTAAATACTGTTAACGACAttgcctttttcgatgacgagggcatcaatgc c" /listShort="S869" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2098040..2098058 /Source="Nicolas_upshift_promotors" /id="U1794" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.958041958041958" /psig="0.958041958041958" /xcortree=1114 /SigmaFactorBS="atttcgagcttttcacttgaactgaaaaaGGTTTGatgcgtc gggtaattGTAAATACTGTTAACGACAttgcctttttcgatgacgagggcatcaatgc c" /listShort="S869" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2098050..2098243 /Source="Nicolas_S_feature" /locus_tag="new_2401843_2402036" /HighExp="S8, S6, S7, S4, S5, C30, S3, BT, B36, C90" /AntisenseName="ypdA" /AntisenseCor="-0.487730736536516" /AntisenseRegPval="-16.8" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.958" /TUlongSig="NA" /TUlongPSig="NA" /label="S869" upshifts 2098050 /Source="Nicolas_upshifts" /id="U1794" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.958041958041958" /psig="0.958041958041958" /xcortree=1114 /SigmaFactorBS="atttcgagcttttcacttgaactgaaaaaGGTTTGatgcgtc gggtaattGTAAATACTGTTAACGACAttgcctttttcgatgacgagggcatcaatgc c" /listShort="S869" /GFF_Attribute="listLong" /label="upshifts" downshifts 2098201 /Source="Nicolas_upshifts" /id="D1200" /incds=0 /nref=13 /ntot=27 /MaxReadThrough="1.93985" /MaxDrop="5.69954" /score="23.7306175" /energy="-9.3" /TU="NA" /idTUdmin="U1794" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2098274..2099557) /gene="gudB" /locus_tag="BSU_22960" /old_locus_tag="BSU22960" /EC_number="1.4.1.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9829940, 18326565, 22178969, 22720735, 25610436" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9829940, 18326565, 22178969, 22720735, 25610436; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cryptic glutamate dehydrogenase (active after removal of a 9 bp insert)" /protein_id="NP_390177.2" /db_xref="EnsemblGenomes-Gn:BSU22960" /db_xref="EnsemblGenomes-Tr:CAB14212" /db_xref="GOA:P50735" /db_xref="InterPro:IPR006095" /db_xref="InterPro:IPR006096" /db_xref="InterPro:IPR006097" /db_xref="InterPro:IPR014362" /db_xref="InterPro:IPR033524" /db_xref="InterPro:IPR033922" /db_xref="InterPro:IPR036291" /db_xref="PDB:3K8Z" /db_xref="SubtiList:BG11435" /db_xref="UniProtKB/Swiss-Prot:P50735" /translation="MAADRNTGHTEEDKLDVLKSTQTVIHKALEKLGYPEEVYELLKE PMRLLTVKIPVRMDDGSVKIFTGYRAQHNDSVGPTKGGIRFHPNVTEKEVKAVKALSI WMSLKCGIIDLPYGGGKGGIVCDPRDMSFRELERLSRGYVRAISQIVGPTKDVPAPDV FTNSQIMAWMMDEYSRIDEFNSPGFITGKPLVLGGSHGRESATAKGVTICIKEAAKKR GIDIKGARVVVQGFGNAGSYLAKFMHDAGAKVVGISDAYGGLYDPEGLDIDYLLDRRD SFGTVTKLFNDTITNQELLELDCDILVPAAIENQITEENAHNIRAKIVVEAANGPTTL EGTKILSDRDILLVPDVLASAGGVTVSYFEWVQNNQGFYWSEEEVEEKLEKMMVKSFN NIYEMANNRRIDMRLAAYMVGVRKMAEASRFRGWI*" /label="gudB CDS" gene complement(2098274..2099557) /gene="gudB" /locus_tag="BSU_22960" /old_locus_tag="BSU22960" /label="gudB gene" downshifts complement(2098277) /Source="Nicolas_upshifts" /id="D1201" /incds=0 /nref=2 /ntot=54 /MaxReadThrough="7.92262" /MaxDrop="4.04542" /score="18.1400723" /energy="-9.3" /TU="U1796" /idTUdmin="U1797" /TUdmin=1345 /isTUend="FALSE" /label="downshifts" promotor_-35 2098315..2098321 /Source="Nicolas_upshift_promotors" /id="U1795" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.001998001998002" /xcortree=59 /SigmaFactorBS="cttatatccagcctctaaaacgcgaagcttcagccattttgc GAACGCCgaccatatatgCAGCGagcctcatgtcaattcttcggttgttagccatttc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2098333..2098337 /Source="Nicolas_upshift_promotors" /id="U1795" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.001998001998002" /xcortree=59 /SigmaFactorBS="cttatatccagcctctaaaacgcgaagcttcagccattttgc GAACGCCgaccatatatgCAGCGagcctcatgtcaattcttcggttgttagccatttc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2098333 /Source="Nicolas_upshifts" /id="U1795" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.001998001998002" /xcortree=59 /SigmaFactorBS="cttatatccagcctctaaaacgcgaagcttcagccattttgc GAACGCCgaccatatatgCAGCGagcctcatgtcaattcttcggttgttagccatttc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2099600..2099619) /Source="Nicolas_upshift_promotors" /id="U1796" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.716283716283716" /psig="0.972027972027972" /xcortree=2225 /SigmaFactorBS="ttttttttcgttaaaaaacatggaaaaacataacgtttatTC TATGCAcagatcatatgaagGTGTATACTATTCTCTGAAAgggagcatgtgagaaaca g" /listShort="gudB, ypdA, prsW" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2099621) /Source="Nicolas_upshifts" /id="U1796" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.716283716283716" /psig="0.972027972027972" /xcortree=2225 /SigmaFactorBS="ttttttttcgttaaaaaacatggaaaaacataacgtttatTC TATGCAcagatcatatgaagGTGTATACTATTCTCTGAAAgggagcatgtgagaaaca g" /listShort="gudB, ypdA, prsW" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2099634..2099641) /Source="Nicolas_upshift_promotors" /id="U1796" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.716283716283716" /psig="0.972027972027972" /xcortree=2225 /SigmaFactorBS="ttttttttcgttaaaaaacatggaaaaacataacgtttatTC TATGCAcagatcatatgaagGTGTATACTATTCTCTGAAAgggagcatgtgagaaaca g" /listShort="gudB, ypdA, prsW" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2099713..2100297) /gene="mecB" /locus_tag="BSU_22970" /old_locus_tag="BSU22970" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11914365, 19801546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11914365, 19801546; Product type f: factor" /codon_start=1 /transl_table=11 /product="adaptor to ClpC; regulator of competence and sporulation" /protein_id="NP_390178.1" /db_xref="EnsemblGenomes-Gn:BSU22970" /db_xref="EnsemblGenomes-Tr:CAB14213" /db_xref="GOA:P50734" /db_xref="InterPro:IPR008681" /db_xref="PDB:3JTN" /db_xref="PDB:3JTO" /db_xref="SubtiList:BG11434" /db_xref="UniProtKB/Swiss-Prot:P50734" /translation="MRLERLNYNKIKIFLTLDDLTDRGLTKEDLWKDSFKVHQLFKDM MNEANTELGFEANGPIAVEVYSLQAQGMVVIVTKNQDADSEDDEYDDDYIEMQVKLDE SADIIYQFHSFEDIIQLSESLQRIGITGGTVYHYDGQYFLSLEDLGSHTAEGVVAVLA EYGNPTTLTIYRLQEYGKLIMDGNAVETIQTHFS*" /label="mecB CDS" gene complement(2099713..2100297) /gene="mecB" /locus_tag="BSU_22970" /old_locus_tag="BSU22970" /label="mecB gene" downshifts complement(2099715) /Source="Nicolas_upshifts" /id="D1202" /incds=0 /nref=258 /ntot=274 /MaxReadThrough="3.02006" /MaxDrop="7.92719" /score="23.8885529" /energy="-7.1" /TU="U1797" /idTUdmin="U1797" /TUdmin="-93" /isTUend="FALSE" /label="downshifts" S_feature complement(2100298..2100379) /Source="Nicolas_S_feature" /locus_tag="new_2404091_2404172_c" /HighExp="dia5, Diami, Etha, dia15, C90, Salt, LPhT, Heat, MG-0.2, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigWXY" /TUlongPSig=1 /label="S870" promotor_-10 complement(2100372..2100391) /Source="Nicolas_upshift_promotors" /id="U1797" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=638 /SigmaFactorBS="atccgtatggcaataaaaactgcattgTGCTTGTCttactag tgaactCAGTGTAAACTGATAACAATtaagaacctatgactcatcatctcatataatg t" /listShort="S870, mecB" /listLong="gudB, ypdA" /label="promotor_-10" upshifts complement(2100379) /Source="Nicolas_upshifts" /id="U1797" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=638 /SigmaFactorBS="atccgtatggcaataaaaactgcattgTGCTTGTCttactag tgaactCAGTGTAAACTGATAACAATtaagaacctatgactcatcatctcatataatg t" /listShort="S870, mecB" /listLong="gudB, ypdA" /label="upshifts" promotor_-35 complement(2100405..2100412) /Source="Nicolas_upshift_promotors" /id="U1797" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=638 /SigmaFactorBS="atccgtatggcaataaaaactgcattgTGCTTGTCttactag tgaactCAGTGTAAACTGATAACAATtaagaacctatgactcatcatctcatataatg t" /listShort="S870, mecB" /listLong="gudB, ypdA" /label="promotor_-35" CDS complement(2100456..2101235) /gene="ypbG" /locus_tag="BSU_22980" /old_locus_tag="BSU22980" /EC_number="3.1.-.-" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15838020, 17434969; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphoesterase" /protein_id="NP_390179.1" /db_xref="EnsemblGenomes-Gn:BSU22980" /db_xref="EnsemblGenomes-Tr:CAB14214" /db_xref="GOA:P50733" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG11433" /db_xref="UniProtKB/Swiss-Prot:P50733" /translation="MKLSVKIAGVLTVAAAAMTAKMYATAKGNHLKTHTFPLSKMKGK PPLTIFFISDIHKRLIDQDLLEKARSHAPHLVIIGGDLAEGGVPSARIEENIKRLVHF GVPIVFVWGNNDYEVRQHKLYSIFKAHGVITLRNESVPFSYNGHTIAIAGVDDIRMEM DHYEEAIKELDESQLNILVCHNPEIHEQINEDDGIDVILSGHTHGGQIRFGKFGPYEL GKTGIVKNAAYLISNGYGTTKVPLRLGAEPETHIVTLCGPE*" /label="ypbG CDS" gene complement(2100456..2101235) /gene="ypbG" /locus_tag="BSU_22980" /old_locus_tag="BSU22980" /label="ypbG gene" promotor_-10 complement(2101261..2101276) /Source="Nicolas_upshift_promotors" /id="U1798" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1649 /SigmaFactorBS="gaaagtaaataaaatggggcgttttctcaaacgatAGAAACG TCTttttttattgtCCGTCTTATTGATAAGttctaaaaagaatggagagttttttatg a" /listShort="ypbG" /listLong="S870, mecB" /label="promotor_-10" upshifts complement(2101272) /Source="Nicolas_upshifts" /id="U1798" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1649 /SigmaFactorBS="gaaagtaaataaaatggggcgttttctcaaacgatAGAAACG TCTttttttattgtCCGTCTTATTGATAAGttctaaaaagaatggagagttttttatg a" /listShort="ypbG" /listLong="S870, mecB" /label="upshifts" promotor_-35 complement(2101288..2101297) /Source="Nicolas_upshift_promotors" /id="U1798" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1649 /SigmaFactorBS="gaaagtaaataaaatggggcgttttctcaaacgatAGAAACG TCTttttttattgtCCGTCTTATTGATAAGttctaaaaagaatggagagttttttatg a" /listShort="ypbG" /listLong="S870, mecB" /label="promotor_-35" CDS complement(2101321..2101764) /gene="ypbF" /locus_tag="BSU_22990" /old_locus_tag="BSU22990" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390180.1" /db_xref="EnsemblGenomes-Gn:BSU22990" /db_xref="EnsemblGenomes-Tr:CAB14215" /db_xref="GOA:P50732" /db_xref="InterPro:IPR020210" /db_xref="SubtiList:BG11432" /db_xref="UniProtKB/Swiss-Prot:P50732" /translation="MESLWNQLDQFTDAPTKQMLQALVKRKQKFENYAAQCRRWRWAS LICLGLLCVMIMIKSPEPQLILQEILSHTFYLFWMLATAFAYCTSYYFKKKEEKSETD FHKLRCEIIQKSTDLWPQPDKWKARESVFHMMKHKYDINLYFESK*" /label="ypbF CDS" gene complement(2101321..2101764) /gene="ypbF" /locus_tag="BSU_22990" /old_locus_tag="BSU22990" /label="ypbF gene" downshifts complement(2101338) /Source="Nicolas_upshifts" /id="D1203" /incds=0 /nref=4 /ntot=112 /MaxReadThrough="4.67294" /MaxDrop="3.33254" /score="6.86206051" /energy="-7.5" /TU="U1801" /idTUdmin="U1799" /TUdmin=22 /isTUend="TRUE" /label="downshifts" CDS complement(2101827..2102549) /gene="ypbE" /locus_tag="BSU_23000" /old_locus_tag="BSU23000" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16855244, 22950025; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme possibly involved in cell wall turnover" /protein_id="NP_390181.1" /db_xref="EnsemblGenomes-Gn:BSU23000" /db_xref="EnsemblGenomes-Tr:CAB14216" /db_xref="GOA:P50731" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG11431" /db_xref="UniProtKB/Swiss-Prot:P50731" /translation="MTNMSRVERRKAQNLYEDQNAALADDYVDDGESLPTRQSVKNQR EQKKKQGKTKTPLFTVLAVIFVFVPVIVLVTLFYLKSHPDNHDDYEDVFIDSSQSKYE VVPKSEDKNDTADTKETALQKESKKEPEDSKPKEQTAADKKQTAVAEKEDSPNKEEAT AAAASSSQSTVQQQEQPAEPVQNVPNRVVKHTVQKKETLYRISMKYYKSRTGEEKIRA YNHLNGNDVYTGQVLDIPLMDE*" /label="ypbE CDS" gene complement(2101827..2102549) /gene="ypbE" /locus_tag="BSU_23000" /old_locus_tag="BSU23000" /label="ypbE gene" downshifts complement(2102108) /Source="Nicolas_upshifts" /id="D1204" /incds=1 /nref=4 /ntot=93 /MaxReadThrough="4.30678" /MaxDrop="3.33147" /score="6.86206051" /energy="-7.5" /TU="U1799,U1801" /idTUdmin="U1799" /TUdmin="-748" /isTUend="FALSE" /label="downshifts" CDS complement(2102500..2103069) /gene="ypbD" /locus_tag="BSU_23010" /old_locus_tag="BSU23010" /function="16.6: Maintain" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="NP_390182.1" /db_xref="EnsemblGenomes-Gn:BSU23010" /db_xref="EnsemblGenomes-Tr:CAB14217" /db_xref="GOA:P50730" /db_xref="InterPro:IPR003675" /db_xref="SubtiList:BG11430" /db_xref="UniProtKB/Swiss-Prot:P50730" /translation="MTQLLIIFAAAAAGLFFFEDVRDVLKLWDIRDMRIIWYGVSIAV IVILADMAVMKWFPSHLYDDGGINKKIFSKRSIPHIIFLTLLIAFAEEMLFRGVLQTH IGLWTASLIFAALHFRYLSKWLLFIMVTAISFLLGLMYEWTGNLFVPMTAHFIIDAVF ACQIRFEHVRRDKHDEHVESREKKSPESL*" /label="ypbD CDS" gene complement(2102500..2103069) /gene="ypbD" /locus_tag="BSU_23010" /old_locus_tag="BSU23010" /label="ypbD gene" promotor_-10 complement(2102818..2102836) /Source="Nicolas_upshift_promotors" /id="U1799" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.466533466533467" /psig="0.466533466533467" /xcortree=1458 /SigmaFactorBS="ctcatttatatgatgacggcggaatcaataaaaaaatATTCA GTaagaggtcaatcccTCATATTATATTTTTAACGcttctgattgctttcgcggaaga a" /listShort="ypbE, ypbF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2102834) /Source="Nicolas_upshifts" /id="U1799" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.466533466533467" /psig="0.466533466533467" /xcortree=1458 /SigmaFactorBS="ctcatttatatgatgacggcggaatcaataaaaaaatATTCA GTaagaggtcaatcccTCATATTATATTTTTAACGcttctgattgctttcgcggaaga a" /listShort="ypbE, ypbF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2102851..2102857) /Source="Nicolas_upshift_promotors" /id="U1799" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.466533466533467" /psig="0.466533466533467" /xcortree=1458 /SigmaFactorBS="ctcatttatatgatgacggcggaatcaataaaaaaatATTCA GTaagaggtcaatcccTCATATTATATTTTTAACGcttctgattgctttcgcggaaga a" /listShort="ypbE, ypbF" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2103088..2103834 /Source="Nicolas_S_feature" /locus_tag="new_2406881_2407627" /HighExp="S6, S8, S7, C30, BT, S5, C90, Pyr, BC, Sw" /AntisenseName="recQ" /AntisenseCor="-0.47918253719211501" /AntisenseRegPval="-16.100000000000001" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S871" CDS complement(2103129..2104619) /gene="recS" /locus_tag="BSU_23020" /old_locus_tag="BSU23020" /EC_number="3.6.1.-" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16385024, 25246477, 26001966, 28527403" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16385024, 25246477, 26001966, 28527403; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent DNA helicase" /protein_id="NP_390183.1" /db_xref="EnsemblGenomes-Gn:BSU23020" /db_xref="EnsemblGenomes-Tr:CAB14218" /db_xref="GOA:P50729" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR002464" /db_xref="InterPro:IPR004589" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11407" /db_xref="UniProtKB/Swiss-Prot:P50729" /translation="MTKLQQTLYQFFGFTSFKKGQQDIIESILSGKDTIAMLPTGGGK SLCYQLPGYMLDGMVLIVSPLLSLMEDQVQQLKARGEKRAAALNSMLNRQERQFVLEH IHRYKFLYLSPEALQSPYVLEKLKSVPISLFVIDEAHCISEWGHDFRPDYSKLGQLRK KLGHPPVLALTATATKETLQDVMNLLELQHAVRHLNSVNRPNIALRVENAADTAEKID RVIQLVENLQGPGIVYCPTRKWAKELAGEIKSKTSSRADFYHGGLESGDRILIQQQFI HNQLDVICCTNAFGMGVDKPDIRYVIHFHLPQTAEAFMQEIGRAGRDGKPSVSILLRA PGDFELQEQIIQMESVTAEEIADVIRVLEKTEERDERRLRDVLLQYGVGETQARMMIH LFMQGKTSVELMKKEISYRMELKLEKMHRVSFLLQRDGCLRQALLTYFDESYEPDDGN LPCCSHCGFDLSLYEQKGERSKMAPLDSWSSELHRIFSLQTVGELN*" /label="recS CDS" gene complement(2103129..2104619) /gene="recS" /locus_tag="BSU_23020" /old_locus_tag="BSU23020" /label="recS gene" CDS complement(2104612..2105670) /gene="gmmB" /locus_tag="BSU_23030" /old_locus_tag="BSU23030" /experiment="publication(s) with functional evidences, PMID:21170359" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21170359; Product type f: factor" /codon_start=1 /transl_table=11 /product="subunit of the platform for genome maintenance machinery" /protein_id="NP_390184.1" /db_xref="EnsemblGenomes-Gn:BSU23030" /db_xref="EnsemblGenomes-Tr:CAB14219" /db_xref="InterPro:IPR008308" /db_xref="InterPro:IPR029491" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11429" /db_xref="UniProtKB/Swiss-Prot:P50728" /translation="MSLNYFDIMVLDCLCKINGERSGSAVFHLFKGKRSSQTIQDAGL FQTAKYFGMAAKCSRSDISASLDKLEKHSYLAPMSESDTYKVTASGAAVLRHALSERP WPVHCHGAHYQQAAGVLWKRLSLLVQVLSHKQQGSRQYIPVTKDHKTLHWVKKYLSRH TDHIEMAKSLFAMLEAHLKKIENKAAQIFVYSLTSHHRIGYTSRQLADTLKEDEWYVY IMFWASVHYFIHSLPECEDALLKDLLSDVHLDNALTESTRKTWQMVKQGFPIQRIAEI RKLKTATIEDHIVEISLHEPAFMINDYVSAEDQLQIAEFAKRMRTNKIKQIRDGLEQR FSYFQIRLALTKQVQQYD*" /label="gmmB CDS" gene complement(2104612..2105670) /gene="gmmB" /locus_tag="BSU_23030" /old_locus_tag="BSU23030" /label="gmmB gene" promotor_-35 2104960..2104969 /Source="Nicolas_upshift_promotors" /id="U1800" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1318 /SigmaFactorBS="tatctaagtgcacatcagaaaggagatcctttaacaaagcAT CTTCACACtccggaagagaaTGAATAAAATAATGTACCGAagcccaaaacatgatata g" /listShort="S872, S873, S874, fer" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2104980..2105770 /Source="Nicolas_S_feature" /locus_tag="new_2408773_2409563" /HighExp="S8, S6, S7, S5, BT, B36, Pyr, G/S, B60, nit" /AntisenseName="ypbB" /AntisenseCor="-0.76734368116597995" /AntisenseRegPval="-52.7" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S872" upshifts 2104980 /Source="Nicolas_upshifts" /id="U1800" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1318 /SigmaFactorBS="tatctaagtgcacatcagaaaggagatcctttaacaaagcAT CTTCACACtccggaagagaaTGAATAAAATAATGTACCGAagcccaaaacatgatata g" /listShort="S872, S873, S874, fer" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2104982..2105001 /Source="Nicolas_upshift_promotors" /id="U1800" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1318 /SigmaFactorBS="tatctaagtgcacatcagaaaggagatcctttaacaaagcAT CTTCACACtccggaagagaaTGAATAAAATAATGTACCGAagcccaaaacatgatata g" /listShort="S872, S873, S874, fer" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2105711..2105730) /Source="Nicolas_upshift_promotors" /id="U1801" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.926073926073926" /psig="0.993006993006993" /xcortree=2277 /SigmaFactorBS="ataaggggttatctacataacatcccccttaatgatgacttt aaaCGTCGATTtctgtttgaaaTCTGTTAAAATAAAAAGAGCaaatcaacgatttttg t" /listShort="ypbB, recQ, ypbD, ypbE, ypbF, ypbG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2105734) /Source="Nicolas_upshifts" /id="U1801" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.926073926073926" /psig="0.993006993006993" /xcortree=2277 /SigmaFactorBS="ataaggggttatctacataacatcccccttaatgatgacttt aaaCGTCGATTtctgtttgaaaTCTGTTAAAATAAAAAGAGCaaatcaacgatttttg t" /listShort="ypbB, recQ, ypbD, ypbE, ypbF, ypbG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2105742..2105749) /Source="Nicolas_upshift_promotors" /id="U1801" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.926073926073926" /psig="0.993006993006993" /xcortree=2277 /SigmaFactorBS="ataaggggttatctacataacatcccccttaatgatgacttt aaaCGTCGATTtctgtttgaaaTCTGTTAAAATAAAAAGAGCaaatcaacgatttttg t" /listShort="ypbB, recQ, ypbD, ypbE, ypbF, ypbG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2105748..2105754 /Source="Nicolas_upshift_promotors" /id="U1802" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=115 /SigmaFactorBS="ctctttttattttaacagatttcaaacagaaatcgaCGTTTA AagtcatcattaagGGGGATGTTATGTAGATAACcccttatgtgataagcattctcaa t" /listShort="S873" /listLong="S874, fer" /label="promotor_-35" promotor_-10 2105768..2105787 /Source="Nicolas_upshift_promotors" /id="U1802" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=115 /SigmaFactorBS="ctctttttattttaacagatttcaaacagaaatcgaCGTTTA AagtcatcattaagGGGGATGTTATGTAGATAACcccttatgtgataagcattctcaa t" /listShort="S873" /listLong="S874, fer" /label="promotor_-10" S_feature 2105772..2105841 /Source="Nicolas_S_feature" /locus_tag="new_2409565_2409634" /HighExp="S6, S8, S7, S5, BT, B36, C30, Pyr, B60, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigK" /TUshortPSig="0.991, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S873" upshifts 2105772 /Source="Nicolas_upshifts" /id="U1802" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=115 /SigmaFactorBS="ctctttttattttaacagatttcaaacagaaatcgaCGTTTA AagtcatcattaagGGGGATGTTATGTAGATAACcccttatgtgataagcattctcaa t" /listShort="S873" /listLong="S874, fer" /label="upshifts" promotor_-35 2105821..2105828 /Source="Nicolas_upshift_promotors" /id="U1803" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.692307692307692" /psig=1 /xcortree=1751 /SigmaFactorBS="ataaccccttatgtgataagcattctcaatcatttttcTGTT GAAAtgtggcagcaacatCATTACAATAAGTAAGAGGAataggtgttaaattgattaa a" /listShort="S874, fer" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2105843..2105935 /Source="Nicolas_S_feature" /locus_tag="new_2409636_2409728" /HighExp="LPhT, LBGstat, HPh, C90, LBGtran, C30, Lbtran, Cold, LPh, MG 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="1, 0.996" /TUlongSig="SigB" /TUlongPSig="0.991" /label="S874" promotor_-10 2105843..2105862 /Source="Nicolas_upshift_promotors" /id="U1803" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.692307692307692" /psig=1 /xcortree=1751 /SigmaFactorBS="ataaccccttatgtgataagcattctcaatcatttttcTGTT GAAAtgtggcagcaacatCATTACAATAAGTAAGAGGAataggtgttaaattgattaa a" /listShort="S874, fer" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2105843 /Source="Nicolas_upshifts" /id="U1803" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.692307692307692" /psig=1 /xcortree=1751 /SigmaFactorBS="ataaccccttatgtgataagcattctcaatcatttttcTGTT GAAAtgtggcagcaacatCATTACAATAAGTAAGAGGAataggtgttaaattgattaa a" /listShort="S874, fer" /GFF_Attribute="listLong" /label="upshifts" CDS 2105936..2106184 /gene="fer" /locus_tag="BSU_23040" /old_locus_tag="BSU23040" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12538057, 21665975" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12538057, 21665975; Product type c: carrier" /codon_start=1 /transl_table=11 /product="ferredoxin" /protein_id="NP_390185.1" /db_xref="EnsemblGenomes-Gn:BSU23040" /db_xref="EnsemblGenomes-Tr:CAB14220" /db_xref="GOA:P50727" /db_xref="InterPro:IPR001080" /db_xref="InterPro:IPR017896" /db_xref="SubtiList:BG11388" /db_xref="UniProtKB/Swiss-Prot:P50727" /translation="MAKYTIVDKDTCIACGACGAAAPDIYDYDDEGIAFVTLDENKGV VEVPEVLEEDMIDAFEGCPTDSIKVADEPFEGDPLKFE*" /label="fer CDS" gene 2105936..2106184 /gene="fer" /locus_tag="BSU_23040" /old_locus_tag="BSU23040" /label="fer gene" downshifts 2106168 /Source="Nicolas_upshifts" /id="D1205" /incds=0 /nref=221 /ntot=291 /MaxReadThrough="3.16016" /MaxDrop="8.38074" /score="34.9672707" /energy="-9.9" /TU="U1803" /idTUdmin="U1800" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2106224..2106796) /gene="fmnP" /locus_tag="BSU_23050" /old_locus_tag="BSU23050" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12456892, 15849754, 16850406, 17693491, 25438558" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12456892, 15849754, 16850406, 17693491, 25438558; Product type t : transporter" /codon_start=1 /transl_table=11 /product="FMN permease" /protein_id="NP_390186.1" /db_xref="EnsemblGenomes-Gn:BSU23050" /db_xref="EnsemblGenomes-Tr:CAB14237" /db_xref="GOA:P50726" /db_xref="InterPro:IPR024529" /db_xref="InterPro:IPR025720" /db_xref="SubtiList:BG11428" /db_xref="UniProtKB/Swiss-Prot:P50726" /translation="MKVKKLVVVSMLSSIAFVLMLLNFPFPGLPDYLKIDFSDVPAII AILIYGPLAGIAVEAIKNVLQYIIQGSMAGVPVGQVANFIAGTLFILPTAFLFKKLNS AKGLAVSLLLGTAAMTILMSILNYVLILPAYTWFLHSPALSDSALKTAVVAGILPFNM IKGIVITVVFSLIFIKLKPWIEQQRSAHIH*" /label="fmnP CDS" gene complement(2106224..2106796) /gene="fmnP" /locus_tag="BSU_23050" /old_locus_tag="BSU23050" /label="fmnP gene" downshifts complement(2106244) /Source="Nicolas_upshifts" /id="D1206" /incds=0 /nref=103 /ntot=231 /MaxReadThrough="2.60651" /MaxDrop="4.95518" /score="35.0684207" /energy="-9.9" /TU="NA" /idTUdmin="U1804" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_RNA complement(2106788..2107095) /gene="fswB" /locus_tag="BSU_misc_RNA_78" /product="flavin mononucleotide riboswitch" /experiment="publication(s) with functional evidences, PMID:12456892, 15808508" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12456892, 15808508; Product type n: RNA" /label="fswB RNA" gene complement(2106788..2107095) /gene="fswB" /locus_tag="BSU_misc_RNA_78" /label="fswB gene" S_feature complement(2106797..2106901) /Source="Nicolas_S_feature" /locus_tag="new_2410590_2410694_c" /HighExp="S1, LPhT, M9-stat, B60, Heat, T0.30H, Gly, S5, BC, S7" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S875" promotor_-10 complement(2107094..2107113) /Source="Nicolas_upshift_promotors" /id="U1804" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.425574425574426" /psig=1 /xcortree=605 /SigmaFactorBS="acagcttgcaggtaatatatttaatttgaagcaattcTCTAT ACagccaaccagttaTCGTTTATAATGTAATTAAAtttcatatgatcaatcttcgggg c" /listShort="ypzE, S875, fmnP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2107110) /Source="Nicolas_upshifts" /id="U1804" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.425574425574426" /psig=1 /xcortree=605 /SigmaFactorBS="acagcttgcaggtaatatatttaatttgaagcaattcTCTAT ACagccaaccagttaTCGTTTATAATGTAATTAAAtttcatatgatcaatcttcgggg c" /listShort="ypzE, S875, fmnP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2107127..2107133) /Source="Nicolas_upshift_promotors" /id="U1804" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.425574425574426" /psig=1 /xcortree=605 /SigmaFactorBS="acagcttgcaggtaatatatttaatttgaagcaattcTCTAT ACagccaaccagttaTCGTTTATAATGTAATTAAAtttcatatgatcaatcttcgggg c" /listShort="ypzE, S875, fmnP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2107222..2107229 /Source="Nicolas_upshift_promotors" /id="U1805" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.887112887112887" /psig="0.995004995004995" /xcortree=3067 /SigmaFactorBS="gatttattaggctttacttttatcctttactgcgtcaataca CGTTGACActcttttgagaataTGTTAAATTATCAGATATTTagtttgtcaatttagg a" /listShort="serA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2107240 /Source="Nicolas_upshifts" /id="U1805" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.887112887112887" /psig="0.995004995004995" /xcortree=3067 /SigmaFactorBS="gatttattaggctttacttttatcctttactgcgtcaataca CGTTGACActcttttgagaataTGTTAAATTATCAGATATTTagtttgtcaatttagg a" /listShort="serA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2107244..2107263 /Source="Nicolas_upshift_promotors" /id="U1805" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.887112887112887" /psig="0.995004995004995" /xcortree=3067 /SigmaFactorBS="gatttattaggctttacttttatcctttactgcgtcaataca CGTTGACActcttttgagaataTGTTAAATTATCAGATATTTagtttgtcaatttagg a" /listShort="serA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2107293..2108870 /gene="serA" /locus_tag="BSU_23070" /old_locus_tag="BSU23070" /EC_number="1.1.1.95" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:168067, 11390694, 17611193, 4337849, 21749987, 22938038, 28827360" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 168067, 11390694, 17611193, 4337849, 21749987, 22938038, 28827360; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-phosphoglycerate dehydrogenase" /protein_id="NP_390188.2" /db_xref="EnsemblGenomes-Gn:BSU23070" /db_xref="EnsemblGenomes-Tr:CAB14239" /db_xref="GOA:P35136" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR006139" /db_xref="InterPro:IPR006140" /db_xref="InterPro:IPR006236" /db_xref="InterPro:IPR029009" /db_xref="InterPro:IPR029752" /db_xref="InterPro:IPR029753" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10509" /db_xref="UniProtKB/Swiss-Prot:P35136" /translation="MFRVLVSDKMSNDGLQPLIESDFIEIVQKNVADAEDELHTFDAL LVRSATKVTEDLFNKMTSLKIVGRAGVGVDNIDIDEATKHGVIVINAPNGNTISTAEH TFAMISSLMRHIPQANISVKSREWNRTAYVGSELYGKTLGIVGLGRIGSEIAQRARAF GMTVHVFDPFLTEERAKKIGVNSRTFEEVLESADIITVHTPLTKETKGLLNKETIAKT KKGVRLINCARGGIIDEAALLEALENGHVAGAALDVFEVEPPVDNKLVDHPLVIATPH LGASTKEAQLNVAAQVSEEVLQFAKGLPVMSAINLPAMTKDEFAKIKPYHQIAGKIGS LVSQCMKEPVQDVAIQYEGTIAKLETSFITKALLSGFLKPRVDSTVNEVNAGGVAKER GISFSEKISSSESGYDNCISVKVTGDRSTFTVTATYIPHFGERIVEINGFNIDFYPTG HLVYIQHQDTTGVIGRVGRILGDNDINIATMQVGRKEKGGEAIMMLSFDRHLEDKIVK ELTNVPDIVSVKLIDLP*" /label="serA CDS" gene 2107293..2108870 /gene="serA" /locus_tag="BSU_23070" /old_locus_tag="BSU23070" /label="serA gene" downshifts 2108852 /Source="Nicolas_upshifts" /id="D1207" /incds=0 /nref=246 /ntot=311 /MaxReadThrough="3.23011" /MaxDrop="8.29454" /score="32.0086708" /energy="-10.2" /TU="U1805" /idTUdmin="U1805" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" CDS complement(2108913..2109680) /gene="aroC" /locus_tag="BSU_23080" /old_locus_tag="BSU23080" /EC_number="4.2.1.10" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6442253" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6442253; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="3-dehydroquinate dehydratase" /protein_id="NP_390189.1" /db_xref="EnsemblGenomes-Gn:BSU23080" /db_xref="EnsemblGenomes-Tr:CAB14240" /db_xref="GOA:P35146" /db_xref="InterPro:IPR001381" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR018508" /db_xref="SubtiList:BG10538" /db_xref="UniProtKB/Swiss-Prot:P35146" /translation="MNVLTIKGVSIGEGMPKIIIPLMGKTEKQILNEAEAVKLLNPDI VEWRVDVFEKANDREAVTKLISKLRKSLEDKLFLFTFRTHKEGGSMEMDESSYLALLE SAIQTKDIDLIDIELFSGDANVKALVSLAEENNVYVVMSNHDFEKTPVKDEIISRLRK MQDLGAHIPKMAVMPNDTGDLLTLLDATYTMKTIYADRPIITMSMAATGLISRLSGEV FGSACTFGAGEEASAPGQIPVSELRSVLDILHKNTRG*" /label="aroC CDS" gene complement(2108913..2109680) /gene="aroC" /locus_tag="BSU_23080" /old_locus_tag="BSU23080" /label="aroC gene" downshifts complement(2108928) /Source="Nicolas_upshifts" /id="D1208" /incds=0 /nref=152 /ntot=231 /MaxReadThrough="2.53428" /MaxDrop="5.12103" /score="24.3727755" /energy="-10.2" /TU="NA" /idTUdmin="U1806" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 2109182..2109794 /Source="Nicolas_S_feature" /locus_tag="new_2412975_2413587" /HighExp="B36, C30, LoTm, B60, C90, HiOs, BI, Sw, T1.0H, BT" /AntisenseName="aroC" /AntisenseCor="4.7354591214804703E-2" /AntisenseRegPval="-0.4" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S876" promotor_-10 complement(2109707..2109726) /Source="Nicolas_upshift_promotors" /id="U1806" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2283 /SigmaFactorBS="taaggctcttttttagttgctattcatataatagaaATTTtc aaaaaaaagttgTACGTGTATAATAAAACAAGgtaaagattgaaaggatttgagacga g" /listShort="aroC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2109720) /Source="Nicolas_upshifts" /id="U1806" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2283 /SigmaFactorBS="taaggctcttttttagttgctattcatataatagaaATTTtc aaaaaaaagttgTACGTGTATAATAAAACAAGgtaaagattgaaaggatttgagacga g" /listShort="aroC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2109741..2109744) /Source="Nicolas_upshift_promotors" /id="U1806" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2283 /SigmaFactorBS="taaggctcttttttagttgctattcatataatagaaATTTtc aaaaaaaagttgTACGTGTATAATAAAACAAGgtaaagattgaaaggatttgagacga g" /listShort="aroC" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2109754 /Source="Nicolas_upshifts" /id="D1209" /incds=0 /nref=10 /ntot=52 /MaxReadThrough="2.02363" /MaxDrop="5.64228" /score="10.7892325" /energy="-8.5" /TU="NA" /idTUdmin="U1805" /TUdmin=704 /isTUend="FALSE" /label="downshifts" CDS complement(2109792..2110898) /gene="rsiX" /locus_tag="BSU_23090" /old_locus_tag="BSU23090" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9139908, 9393439, 10712692, 14762009, 16306698" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9139908, 9393439, 10712692, 14762009, 16306698; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative regulator of sigma(X) activity" /protein_id="NP_390190.2" /db_xref="EnsemblGenomes-Gn:BSU23090" /db_xref="EnsemblGenomes-Tr:CAB14241" /db_xref="GOA:P35166" /db_xref="InterPro:IPR019606" /db_xref="SubtiList:BG10537" /db_xref="UniProtKB/Swiss-Prot:P35166" /translation="MMKSEWNEEQIKELLSQLPAVKDHRSPQDIYKRLTMAKRKNKPA VRWIGPACAAAIAVYIAFIISPHFFDQAQPQQKEASQENAVTKTETEDSPKAASSLDQ TSFVVPEKEQDNYITVAVADADTSAIIPVSIQKTNADQTIQDMLFESSELGILDHAIT IPTFIDEVEIKEKPKQKELSIRVHQPATAFSIKDDTLLKKLLKESLKWSPYEKVKFLS DQNETGVRIGSYGTFTEISIPKQSKRSYYLYQNKQGQDFLVPSNHSFDTVKEAIKEME SSSQEDTTPLIQAGAVQSVTKKQKHLYIRFSKESEVDDSIAGILMIEGLLLTAKEFGF TEVTFTETRTKKIGKYDISDAIPVPAAPNPISLN*" /label="rsiX CDS" gene complement(2109792..2110898) /gene="rsiX" /locus_tag="BSU_23090" /old_locus_tag="BSU23090" /label="rsiX gene" downshifts complement(2109809) /Source="Nicolas_upshifts" /id="D1210" /incds=0 /nref=155 /ntot=242 /MaxReadThrough="3.84557" /MaxDrop="5.30684" /score="7.9467954" /energy="-6.7" /TU="U1809" /idTUdmin="U1806" /TUdmin="-881" /isTUend="FALSE" /label="downshifts" CDS complement(2110834..2111418) /gene="sigX" /locus_tag="BSU_23100" /old_locus_tag="BSU23100" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9636707, 11222589, 12399481, 14762009, 19767430, 27965645" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9636707, 11222589, 12399481, 14762009, 19767430, 27965645; Product type r : regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase ECF(extracytoplasmic function)-type sigma factor sigma(X)" /protein_id="NP_390191.2" /db_xref="EnsemblGenomes-Gn:BSU23100" /db_xref="EnsemblGenomes-Tr:CAB14242" /db_xref="GOA:P35165" /db_xref="InterPro:IPR000838" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013249" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10536" /db_xref="UniProtKB/Swiss-Prot:P35165" /translation="MEETFQLLYDTYHQDLYQFLFYMVKDKNQTEDLLQEVYIRVLNS YHTFEGRSSEKTWLLSIARHVAIDWFRKQQTIRQRILGTFDWDTQDVRDQQLLPDELA VQHENVREIYAALDQCTIDQRAVIILRFIQGYSIQETAKALRFSESKVKTTQHRGLKV LRKHMELLREELMDDEVRMERRTDKGVVKSTSGS*" /label="sigX CDS" gene complement(2110834..2111418) /gene="sigX" /locus_tag="BSU_23100" /old_locus_tag="BSU23100" /label="sigX gene" promotor_-35 2111212..2111217 /Source="Nicolas_upshift_promotors" /id="U1807" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95004995004995" /psig="0.018981018981019" /xcortree=30 /SigmaFactorBS="aatgtaccgagtatacgctgtctgattgtttgctgtttacgg aaCCAGTCtatcgcaacatggcGTGCGatagacaaaagccatgttttttcactgcttc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2111228 /Source="Nicolas_upshifts" /id="U1807" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95004995004995" /psig="0.018981018981019" /xcortree=30 /SigmaFactorBS="aatgtaccgagtatacgctgtctgattgtttgctgtttacgg aaCCAGTCtatcgcaacatggcGTGCGatagacaaaagccatgttttttcactgcttc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2111232..2111236 /Source="Nicolas_upshift_promotors" /id="U1807" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95004995004995" /psig="0.018981018981019" /xcortree=30 /SigmaFactorBS="aatgtaccgagtatacgctgtctgattgtttgctgtttacgg aaCCAGTCtatcgcaacatggcGTGCGatagacaaaagccatgttttttcactgcttc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 2111369..2111374 /Source="Nicolas_upshift_promotors" /id="U1808" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1055 /SigmaFactorBS="ttctgtctggtttttatcctttaccatataaaataaaaattg gTACAAAtcttgatgatatgtaTCATATAATAATTGAAAGGtttcttccatttgaaac c" /listShort="S877" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2111386 /Source="Nicolas_upshifts" /id="U1808" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1055 /SigmaFactorBS="ttctgtctggtttttatcctttaccatataaaataaaaattg gTACAAAtcttgatgatatgtaTCATATAATAATTGAAAGGtttcttccatttgaaac c" /listShort="S877" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2111390..2111408 /Source="Nicolas_upshift_promotors" /id="U1808" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1055 /SigmaFactorBS="ttctgtctggtttttatcctttaccatataaaataaaaattg gTACAAAtcttgatgatatgtaTCATATAATAATTGAAAGGtttcttccatttgaaac c" /listShort="S877" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 2111426 /Source="Nicolas_upshifts" /id="D1211" /incds=0 /nref=8 /ntot=81 /MaxReadThrough="5.89234" /MaxDrop="4.38483" /score="6.57298987" /energy="-13.5" /TU="U1808" /idTUdmin="U1807" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2111467..2111486) /Source="Nicolas_upshift_promotors" /id="U1809" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.565434565434565" /psig="0.998001998001998" /xcortree=2781 /SigmaFactorBS="aaaatttaaggatatgttaatataaattcCCTTCCAAattcc agttactCGTAATATAGTTGTAATGTAacttttcaagctattcatacgacaaaaaagt g" /listShort="sigX, rsiX, aroC" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2111471..2111578 /Source="Nicolas_S_feature" /locus_tag="new_2415264_2415371" /HighExp="S4, S8, S6, S7, C30, S3, LoTm, B60, BT, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.956" /TUlongSig="NA" /TUlongPSig="NA" /label="S877" upshifts complement(2111475) /Source="Nicolas_upshifts" /id="U1809" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.565434565434565" /psig="0.998001998001998" /xcortree=2781 /SigmaFactorBS="aaaatttaaggatatgttaatataaattcCCTTCCAAattcc agttactCGTAATATAGTTGTAATGTAacttttcaagctattcatacgacaaaaaagt g" /listShort="sigX, rsiX, aroC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2111499..2111506) /Source="Nicolas_upshift_promotors" /id="U1809" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.565434565434565" /psig="0.998001998001998" /xcortree=2781 /SigmaFactorBS="aaaatttaaggatatgttaatataaattcCCTTCCAAattcc agttactCGTAATATAGTTGTAATGTAacttttcaagctattcatacgacaaaaaagt g" /listShort="sigX, rsiX, aroC" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2111534 /Source="Nicolas_upshifts" /id="D1212" /incds=0 /nref=12 /ntot=64 /MaxReadThrough="2.08559" /MaxDrop="4.36303" /score="6.57298987" /energy="-13.5" /TU="NA" /idTUdmin="U1808" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" S_feature complement(2111563..2111621) /Source="Nicolas_S_feature" /locus_tag="new_2415356_2415414_c" /HighExp="Lbstat, BI, nit, S0, M40t90, Lbtran, M0t90, G135, Sw, ferm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S878" downshifts complement(2111594) /Source="Nicolas_upshifts" /id="D1213" /incds=0 /nref=156 /ntot=252 /MaxReadThrough="2.62215" /MaxDrop="6.99198" /score="33.3049318" /energy="-13.5" /TU="NA" /idTUdmin="U1810" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS complement(2111622..2113391) /gene="resE" /locus_tag="BSU_23110" /old_locus_tag="BSU23110" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11222591, 14996800, 16825793, 16885456, 17189364, 17322317, 17628154" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11222591, 14996800, 16825793, 16885456, 17189364, 17322317, 17628154; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase (ResD / ResE)" /protein_id="NP_390192.1" /db_xref="EnsemblGenomes-Gn:BSU23110" /db_xref="EnsemblGenomes-Tr:CAB14243" /db_xref="GOA:P35164" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR013767" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="PDB:4ZR7" /db_xref="SubtiList:BG10535" /db_xref="UniProtKB/Swiss-Prot:P35164" /translation="MKFWKSVVGKLWFTILSLVLIVLFILTVLLLEFIENYHVEEAEN DLTQLANKVAVILENHEDQALARSITWELADNLTSIAIIQDEKNHWYSPNDKNRLSSI TVEQIQHDKDLNKALKDHKKVSKRTGLSDTDTDNERLIVGVPYEKDGKKGMVFLSQSL LAVKDTTKHTTRYIFLAAGIAIVLTTFFAFFLSSRVTYPLRKMREGAQDLAKGKFDTK IPILTQDEIGELATAFNQMGRQLNFHINALNQEKEQLSNILSSMADGVITINIDGTIL VTNPPAERFLQAWYYEQNMNIKEGDNLPPEAKELFQNAVSTEKEQMIEMTLQGRSWVL LMSPLYAESHVRGAVAVLRDMTEERRLDKLREDFIANVSHELRTPISMLQGYSEAIVD DIASSEEDRKEIAQIIYDESLRMGRLVNDLLDLARMESGHTGLHYEKINVNEFLEKII RKFSGVAKEKNIALDHDISLTEEEFMFDEDKMEQVFTNLIDNALRHTSAGGSVSISVH SVKDGLKIDIKDSGSGIPEEDLPFIFERFYKADKARTRGRAGTGLGLAIVKNIVEAHN GSITVHSRIDKGTTFSFYIPTKR*" /label="resE CDS" gene complement(2111622..2113391) /gene="resE" /locus_tag="BSU_23110" /old_locus_tag="BSU23110" /label="resE gene" downshifts complement(2111678) /Source="Nicolas_upshifts" /id="D1214" /incds=0 /nref=5 /ntot=13 /MaxReadThrough="7.56028" /MaxDrop="3.58685" /score="33.3049318" /energy="-13.5" /TU="U1810,U1811,U1812" /idTUdmin="U1810" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" CDS complement(2113388..2114110) /gene="resD" /locus_tag="BSU_23120" /old_locus_tag="BSU23120" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10972836, 15028686, 15375128, 16825793, 16885456, 17322317, 17628154" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10972836, 15028686, 15375128, 16825793, 16885456, 17322317, 17628154; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator (ResD / ResE)" /protein_id="NP_390193.2" /db_xref="EnsemblGenomes-Gn:BSU23120" /db_xref="EnsemblGenomes-Tr:CAB14244" /db_xref="GOA:P35163" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10534" /db_xref="UniProtKB/Swiss-Prot:P35163" /translation="MDQTNETKILVVDDEARIRRLLRMYLERENYAIDEAENGDEAIA KGLEANYDLILLDLMMPGTDGIEVCRQIREKKATPIIMLTAKGEEANRVQGFEAGTDD YIVKPFSPREVVLRVKALLRRASQTSYFNANTPTKNVLVFSHLSIDHDAHRVTADGTE VSLTPKEYELLYFLAKTPDKVYDREKLLKEVWQYEFFGDLRTVDTHVKRLREKLNKVS PEAAKKIVTVWGVGYKFEVGAE*" /label="resD CDS" gene complement(2113388..2114110) /gene="resD" /locus_tag="BSU_23120" /old_locus_tag="BSU23120" /label="resD gene" S_feature complement(2114111..2114190) /Source="Nicolas_S_feature" /locus_tag="new_2417904_2417983_c" /HighExp="Lbstat, M0t90, ferm, M40t90, S2, S0, nit, M40t45, BI, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigEF" /TUshortPSig="0.998, 0.998, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S879" CDS complement(2114191..2115366) /gene="resC" /locus_tag="BSU_23130" /old_locus_tag="BSU23130" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10844653, 12682299, 15849754, 16850406, 19682263" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10844653, 12682299, 15849754, 16850406, 19682263; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor required for cytochrome c synthesis" /protein_id="NP_390194.2" /db_xref="EnsemblGenomes-Gn:BSU23130" /db_xref="EnsemblGenomes-Tr:CAB14245" /db_xref="GOA:P35162" /db_xref="InterPro:IPR002541" /db_xref="InterPro:IPR017562" /db_xref="SubtiList:BG10533" /db_xref="UniProtKB/Swiss-Prot:P35162" /translation="MAELSGNFLYAAFLVYLIAVPIFGGAIRGNKDKKGRPNRWANIG ITLSIVGFFCHLGYFITRWAASGHAPVSNMFEFTTAFGMMLVLAFIILYFLYRLPSLG LFTLSIALLLIAYASMFPTDISPLIPSLQSNWLYIHVTTAALGQAILAISFVAGVIFL LKHVDQTKPSKKTFWLEAIMFILVTTVAFIAITSAFRLAGYEAEFNWVDKSKEKSVMV YEMPALVGPHQGELLTEGRMEPLVDLPALFSGRKVNTVIWSFGAGLVLYGALRLIIRK RISALLHPLVKNVNLDLVDEVGYRAVSIGFPIFTLGALIFAMIWAQLAWTRFWGWDPK EVWALITFLFYAAYLHLRLSRGWHGEKSAWLAVIGFAIIMFNLIFVNLVLAGLHSYA* " /label="resC CDS" gene complement(2114191..2115366) /gene="resC" /locus_tag="BSU_23130" /old_locus_tag="BSU23130" /label="resC gene" CDS complement(2115386..2117014) /gene="resB" /locus_tag="BSU_23140" /old_locus_tag="BSU23140" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:9395519, 10844653, 12682299, 16825793, 19682263" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9395519, 10844653, 12682299, 16825793, 19682263; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor required for cytochrome c synthesis" /protein_id="NP_390195.1" /db_xref="EnsemblGenomes-Gn:BSU23140" /db_xref="EnsemblGenomes-Tr:CAB14246" /db_xref="GOA:P35161" /db_xref="InterPro:IPR007816" /db_xref="SubtiList:BG10532" /db_xref="UniProtKB/Swiss-Prot:P35161" /translation="MKQVKCECGHINPVGTVLCESCGRALQETQPPLADMRYDGSARR SQTYNKTIIDKIWNFFSSVKVGIWLIVITLAASAFGTIFPQEAYLPPGAQADTYYKEQ YGTFGQLYYLLGFHHLYGSWWYLLLIASIGISLVICSLDRVIPLYRALKNQGVRRSPA FLRRQRLFSETVTVLNGESKEKIVTLLKKKHYRIREKEGSILAEKGRFSRWGPYVNHI GLIIFLIGAMLRFVPGMYVDETLWVREGETAAIPGTDGKYYLKNNQFSVETYNSKTEK KVFADAIDRVGDGRVAKNFQTDAVLYKREGKIVYGEKPKLEKVTEEDIRVNQPLRFDS FSVYQVDYKENQLDQMVFQLIDKKTKKSFGSLKINLLDPDSVYDLGNGYKVEIASYLP DFYFNQDGEPSTKTKIPNNPAFVFNIITPDKPKGEKSFVAIQETIEGSGNNKYKLKFD HVETKNITGLTVRKDLTLWVLAVGGAIFMIGVIQGMYWQHRRIWLHSQDGAVMVAGHT NKNWFGLKKDLAFILADSGLTEPVDQKELIKTQK*" /label="resB CDS" gene complement(2115386..2117014) /gene="resB" /locus_tag="BSU_23140" /old_locus_tag="BSU23140" /label="resB gene" CDS complement(2117011..2117550) /gene="resA" /locus_tag="BSU_23150" /old_locus_tag="BSU23150" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:12637552, 12682299, 15667290, 16537372, 16825793, 16971393, 17189364, 18456809, 19682263, 22720735, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12637552, 12682299, 15667290, 16537372, 16825793, 16971393, 17189364, 18456809, 19682263, 22720735, 26735940; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="extracytoplasmic thioredoxin involved in cytochrome c maturation (lipoprotein)" /protein_id="NP_390196.2" /db_xref="EnsemblGenomes-Gn:BSU23150" /db_xref="EnsemblGenomes-Tr:CAB14247" /db_xref="GOA:P35160" /db_xref="InterPro:IPR000866" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR017937" /db_xref="InterPro:IPR023555" /db_xref="InterPro:IPR036249" /db_xref="PDB:1ST9" /db_xref="PDB:1SU9" /db_xref="PDB:2F9S" /db_xref="PDB:2H19" /db_xref="PDB:2H1A" /db_xref="PDB:2H1B" /db_xref="PDB:2H1D" /db_xref="PDB:2H1G" /db_xref="PDB:3C71" /db_xref="PDB:3C73" /db_xref="SubtiList:BG10531" /db_xref="UniProtKB/Swiss-Prot:P35160" /translation="MKKKRRLFIRTGILLVLICALGYTIYNAVFAGKESISEGSDAPN FVLEDTNGKRIELSDLKGKGVFLNFWGTWCEPCKKEFPYMANQYKHFKSQGVEIVAVN VGESKIAVHNFMKSYGVNFPVVLDTDRQVLDAYDVSPLPTTFLINPEGKVVKVVTGTM TESMIHDYMNLIKPGETSG*" /label="resA CDS" gene complement(2117011..2117550) /gene="resA" /locus_tag="BSU_23150" /old_locus_tag="BSU23150" /label="resA gene" S_feature complement(2117551..2117644) /Source="Nicolas_S_feature" /locus_tag="new_2421344_2421437_c" /HighExp="LBGtran, LBGstat, G180, Oxctl, H2O2, G150, M0t90, G135, Paraq, LPhT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigEF" /TUshortPSig="0.998, 0.998, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S880" CDS complement(2117645..2118379) /gene="rluB" /locus_tag="BSU_23160" /old_locus_tag="BSU23160" /EC_number="4.2.1.70" /function="16.13: Shape" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9888802, 24214967" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9888802, 24214967; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="23S rRNA pseudouridine 2633 (=2605 standard) pseudouridine synthase" /protein_id="NP_390197.2" /db_xref="EnsemblGenomes-Gn:BSU23160" /db_xref="EnsemblGenomes-Tr:CAB14248" /db_xref="GOA:P35159" /db_xref="InterPro:IPR000748" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR006145" /db_xref="InterPro:IPR018496" /db_xref="InterPro:IPR020103" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG10530" /db_xref="UniProtKB/Swiss-Prot:P35159" /translation="MERLQKVIAHAGVASRRKAEELIKEGKVKVNGKVVTELGVKVTG SDQIEVNGLKVEREEPVYFLLYKPRGVISAAQDDKGRKVVTDFFKNIPQRIYPIGRLD YDTSGLLLLTNDGEFANKLMHPKYEIDKTYVAKVKGIPPKELLRKLERGIRLEEGKTA PAKAKLLSLDKKKQTSIIQLTIHEGRNRQVRRMFEAIGHEVIKLKREEYAFLNLRGLH TGDARELTPHEVKRLRALADHGKNAF*" /label="rluB CDS" gene complement(2117645..2118379) /gene="rluB" /locus_tag="BSU_23160" /old_locus_tag="BSU23160" /label="rluB gene" promotor_-10 complement(2118388..2118407) /Source="Nicolas_upshift_promotors" /id="U1810" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.616383616383616" /psig="0.998001998001998" /xcortree=2676 /SigmaFactorBS="aaaacggcgttttttttagatttggcataggaatttgaaaaa gctTGTTTgttaaggttgaaaaAAGTAAGATAATACTTGAGGtgaaagacatggaaag a" /listShort="rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2118411) /Source="Nicolas_upshifts" /id="U1810" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.616383616383616" /psig="0.998001998001998" /xcortree=2676 /SigmaFactorBS="aaaacggcgttttttttagatttggcataggaatttgaaaaa gctTGTTTgttaaggttgaaaaAAGTAAGATAATACTTGAGGtgaaagacatggaaag a" /listShort="rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2118422..2118426) /Source="Nicolas_upshift_promotors" /id="U1810" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.616383616383616" /psig="0.998001998001998" /xcortree=2676 /SigmaFactorBS="aaaacggcgttttttttagatttggcataggaatttgaaaaa gctTGTTTgttaaggttgaaaaAAGTAAGATAATACTTGAGGtgaaagacatggaaag a" /listShort="rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2118471..2119007) /gene="spmB" /locus_tag="BSU_23170" /old_locus_tag="BSU23170" /function="16.13: Shape" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7642500, 15849754, 16850406, 19189487" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7642500, 15849754, 16850406, 19189487; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore maturation protein" /protein_id="NP_390198.2" /db_xref="EnsemblGenomes-Gn:BSU23170" /db_xref="EnsemblGenomes-Tr:CAB14249" /db_xref="GOA:P35158" /db_xref="InterPro:IPR011642" /db_xref="SubtiList:BG10529" /db_xref="UniProtKB/Swiss-Prot:P35158" /translation="MEIINWLSLAMIPIIIAGILLYGTIKKVPTYESFVEGGKEGIEI AFSIIPYLVGMLVAITVFRSSGALDFIMDLLKPAFSAIGIPAEVVPLALIRPISGTAA LGMTTDLIAVYGPDSFIGRLASVMQGSTDTTLYVLTVYFGAVGIKKMGDALKVGLLAD LIGVVASIIIVTLLFGSA*" /label="spmB CDS" gene complement(2118471..2119007) /gene="spmB" /locus_tag="BSU_23170" /old_locus_tag="BSU23170" /label="spmB gene" promotor_-10 complement(2118476..2118495) /Source="Nicolas_upshift_promotors" /id="U1811" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.816183816183816" /psig="0.998001998001998" /xcortree=2645 /SigmaFactorBS="acttcttgcagatttaatcggcgTAGTTGCAtctatcatcat cgtTACGTTATTATTTGGGAGCGcctgaaaacggcgttttttttagatttggcatagg a" /listShort="rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2118480) /Source="Nicolas_upshifts" /id="U1811" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.816183816183816" /psig="0.998001998001998" /xcortree=2645 /SigmaFactorBS="acttcttgcagatttaatcggcgTAGTTGCAtctatcatcat cgtTACGTTATTATTTGGGAGCGcctgaaaacggcgttttttttagatttggcatagg a" /listShort="rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2118510..2118517) /Source="Nicolas_upshift_promotors" /id="U1811" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.816183816183816" /psig="0.998001998001998" /xcortree=2645 /SigmaFactorBS="acttcttgcagatttaatcggcgTAGTTGCAtctatcatcat cgtTACGTTATTATTTGGGAGCGcctgaaaacggcgttttttttagatttggcatagg a" /listShort="rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2119012..2119602) /gene="spmA" /locus_tag="BSU_23180" /old_locus_tag="BSU23180" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7642500, 15849754, 16850406, 19189487" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7642500, 15849754, 16850406, 19189487; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore maturation protein" /protein_id="NP_390199.1" /db_xref="EnsemblGenomes-Gn:BSU23180" /db_xref="EnsemblGenomes-Tr:CAB14250" /db_xref="GOA:P35157" /db_xref="InterPro:IPR011642" /db_xref="SubtiList:BG10528" /db_xref="UniProtKB/Swiss-Prot:P35157" /translation="MVNIIWVSLTVIGLVFAMCNGTLQDVNEAVFKGAKEAITISFGL MSVLVFWLGLMKIAEQSGLLDIFSRMCRPFISKLFPDIPPDHPAMGYILSNLMANFFG LGNAATPLGIKAMEQMKKLNGNRSEASRSMITFLAVNTSCITLIPTTVIAVRMAYSSK TPTDIVGPSILATLISGIGAIIIDRYFYYRRKKKGR*" /label="spmA CDS" gene complement(2119012..2119602) /gene="spmA" /locus_tag="BSU_23180" /old_locus_tag="BSU23180" /label="spmA gene" CDS complement(2119590..2120738) /gene="dacB" /locus_tag="BSU_23190" /old_locus_tag="BSU23190" /EC_number="3.4.16.4" /function="16.13: Shape" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7642500, 8892816, 9864321, 10498740, 18266856, 19542328" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7642500, 8892816, 9864321, 10498740, 18266856, 19542328; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 5*) (required for spore cortex)" /protein_id="NP_390200.1" /db_xref="EnsemblGenomes-Gn:BSU23190" /db_xref="EnsemblGenomes-Tr:CAB14251" /db_xref="GOA:P35150" /db_xref="InterPro:IPR001967" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR012907" /db_xref="InterPro:IPR018044" /db_xref="PDB:3MFD" /db_xref="SubtiList:BG10527" /db_xref="UniProtKB/Swiss-Prot:P35150" /translation="MRIFKKAVFVIMISFLIATVNVNTAHAAIDVSAKSAIIIDGASG RVLYAKDEHQKRRIASITKIMTAVLAIESGKMDQTVTVSANAVRTEGSAIYLTEGQKV KLKDLVYGLMLRSGNDAAVAIAEHVGGSLDGFVYMMNQKAEQLGMKNTRFQNPHGLDD HENHYSTAYDMAILTKYAMKLKDYQKISGTKIYKAETMESVWKNKNKLLTMLYPYSTG GKTGYTKLAKRTLVSTASKDGIDLIAVTINDPNDWDDHMKMFNYVFEHYQTYLIAKKG DIPKLKGTFYESKAFIKRDITYLLTEEEKENVKINTTLLKPKKAWEKDASKIPDIVGH MEIMFNDATIAKVPIYYENERHQKPKKQFFETFKSIFLNAAGGAKWSI*" /label="dacB CDS" gene complement(2119590..2120738) /gene="dacB" /locus_tag="BSU_23190" /old_locus_tag="BSU23190" /label="dacB gene" promotor_-10 complement(2120760..2120778) /Source="Nicolas_upshift_promotors" /id="U1812" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=990 /SigmaFactorBS="tatgtttgcttccagaaatataattgttaTTCATAactgatg gacatgcGCATAAACTTGTACAAACCaccacaaggacgtgagcaaacatgcgcatttt c" /listShort="dacB, spmA, spmB, rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2120767) /Source="Nicolas_upshifts" /id="U1812" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=990 /SigmaFactorBS="tatgtttgcttccagaaatataattgttaTTCATAactgatg gacatgcGCATAAACTTGTACAAACCaccacaaggacgtgagcaaacatgcgcatttt c" /listShort="dacB, spmA, spmB, rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2120793..2120798) /Source="Nicolas_upshift_promotors" /id="U1812" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=990 /SigmaFactorBS="tatgtttgcttccagaaatataattgttaTTCATAactgatg gacatgcGCATAAACTTGTACAAACCaccacaaggacgtgagcaaacatgcgcatttt c" /listShort="dacB, spmA, spmB, rluB, S880, resA, resB, resC, S879, resD, resE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2120861..2121400) /gene="ypuI" /locus_tag="BSU_23200" /old_locus_tag="BSU23200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12065423" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390201.1" /db_xref="EnsemblGenomes-Gn:BSU23200" /db_xref="EnsemblGenomes-Tr:CAB14252" /db_xref="InterPro:IPR025013" /db_xref="SubtiList:BG10526" /db_xref="UniProtKB/Swiss-Prot:P35156" /translation="MKEAKCERQIHEGKIPNEMGHSIVRAQTQKTGEFLSMVVNTVND YLNQTTLESLQAELPIEKGYCCDVLSTLRRMAVFCEGGAEACRRLLMQEPFQEARAEK TLYNVYHQCIEEFFMPKKDTWCENSRASYTGVSAIEFYHAVPASLEQLLLPLSAAFLK MREELAHYEASGSSMAPIR*" /label="ypuI CDS" gene complement(2120861..2121400) /gene="ypuI" /locus_tag="BSU_23200" /old_locus_tag="BSU23200" /label="ypuI gene" downshifts complement(2120874) /Source="Nicolas_upshifts" /id="D1215" /incds=0 /nref=219 /ntot=260 /MaxReadThrough="1.63638" /MaxDrop="8.00748" /score="36.7302977" /energy="-12.2" /TU="NA" /idTUdmin="U1813" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2121409..2121426) /Source="Nicolas_upshift_promotors" /id="U1813" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.436563436563437" /psig="0.436563436563437" /xcortree=810 /SigmaFactorBS="tttaaccaaaccttcgaagatataaaatagaagtttaaTGAA TCgcgctttttcatcaTCATAAGATATAAGGAAGaagctatcatgaaagaagcaaaat g" /listShort="ypuI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2121424) /Source="Nicolas_upshifts" /id="U1813" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.436563436563437" /psig="0.436563436563437" /xcortree=810 /SigmaFactorBS="tttaaccaaaccttcgaagatataaaatagaagtttaaTGAA TCgcgctttttcatcaTCATAAGATATAAGGAAGaagctatcatgaaagaagcaaaat g" /listShort="ypuI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2121441..2121446) /Source="Nicolas_upshift_promotors" /id="U1813" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.436563436563437" /psig="0.436563436563437" /xcortree=810 /SigmaFactorBS="tttaaccaaaccttcgaagatataaaatagaagtttaaTGAA TCgcgctttttcatcaTCATAAGATATAAGGAAGaagctatcatgaaagaagcaaaat g" /listShort="ypuI" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2121455..2122048) /gene="spcB" /locus_tag="BSU_23210" /old_locus_tag="BSU23210" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:12065423, 12100548, 12682299, 12897137, 16272394, 23541893, 24440393, 25951515, 26904953, 27435445, 28286005" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12065423, 12100548, 12682299, 12897137, 16272394, 23541893, 24440393, 25951515, 26904953, 27435445, 28286005; Product type f : factor" /codon_start=1 /transl_table=11 /product="chromosome condensation and segregation factor" /protein_id="NP_390202.1" /db_xref="EnsemblGenomes-Gn:BSU23210" /db_xref="EnsemblGenomes-Tr:CAB14253" /db_xref="GOA:P35155" /db_xref="InterPro:IPR005234" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10525" /db_xref="UniProtKB/Swiss-Prot:P35155" /translation="MGLDIVNWKAIVEALLYAAGDEGLTKKQLLTVLEIEEPELNTIM ADVADEYRGDTRGIELIEYADTYMLSTKKDFAPYLKKLIEVPSKGLSQASLEVLAIVS YKQPITRAEIEEIRGVKSERILHSLVAKALLCEVGRADGPGRAILYGTTPTFLEQFGL KTLDELPPLPENAEEDVLQEEADLFFENFNQTFEDIK*" /label="spcB CDS" gene complement(2121455..2122048) /gene="spcB" /locus_tag="BSU_23210" /old_locus_tag="BSU23210" /label="spcB gene" CDS complement(2122038..2122793) /gene="scpA" /locus_tag="BSU_23220" /old_locus_tag="BSU23220" /function="16.13: Shape" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:12065423, 12100548, 12682299, 12897137, 16272394, 23541893, 24440393, 25951515, 26904953, 28286005" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12065423, 12100548, 12682299, 12897137, 16272394, 23541893, 24440393, 25951515, 26904953, 28286005; Product type f: factor" /codon_start=1 /transl_table=11 /product="chromosome condensation and partitioning factor" /protein_id="NP_390203.1" /db_xref="EnsemblGenomes-Gn:BSU23220" /db_xref="EnsemblGenomes-Tr:CAB14254" /db_xref="GOA:P35154" /db_xref="InterPro:IPR003768" /db_xref="PDB:3ZGX" /db_xref="PDB:5H66" /db_xref="PDB:5H67" /db_xref="PDB:5XG3" /db_xref="SubtiList:BG10524" /db_xref="UniProtKB/Swiss-Prot:P35154" /translation="MEEYQVKIDTFEGPLDLLLHLINRLEIDIYDIPVAKITEQYLLY VHTMRVLELDIASEYLVMAATLLSIKSRMLLPKQEEELFEDELLEEEDPREELIEKLI EYRKYKDAAKDLKEREEERQKSFTKPPSDLSEYAKEVKQSEQKLSVTVYDMIGAFQKV LKRKKINRPMETTITRQDIPIEARMNEIVHSLKSRGTRINFMDLFPYEQKEHLVVTFL AVLELMKNQLVLIEQEHNFSDIYITGSESIHGA*" /label="scpA CDS" gene complement(2122038..2122793) /gene="scpA" /locus_tag="BSU_23220" /old_locus_tag="BSU23220" /label="scpA gene" promotor_-35 2122637..2122646 /Source="Nicolas_upshift_promotors" /id="U1814" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1387 /SigmaFactorBS="cataaccaaatactcgctggcaatgtcgaGCTCAAGCACgcg catcgtatgTACATATAATAAATATTGTTcagtgatcttcgccacaggtatatcatat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2122659..2122678 /Source="Nicolas_upshift_promotors" /id="U1814" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1387 /SigmaFactorBS="cataaccaaatactcgctggcaatgtcgaGCTCAAGCACgcg catcgtatgTACATATAATAAATATTGTTcagtgatcttcgccacaggtatatcatat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2122668 /Source="Nicolas_upshifts" /id="U1814" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1387 /SigmaFactorBS="cataaccaaatactcgctggcaatgtcgaGCTCAAGCACgcg catcgtatgTACATATAATAAATATTGTTcagtgatcttcgccacaggtatatcatat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2122839..2122858) /Source="Nicolas_upshift_promotors" /id="U1815" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.862137862137862" /psig=1 /xcortree=2560 /SigmaFactorBS="ctgtacaaactccttcaaaacaggatatgaaatagTATTGGA CgagagctttttggTGGCTTATACTATAGGGTAGccagtttttccggcaatgagagtg a" /listShort="scpA, spcB, ypuI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2122854) /Source="Nicolas_upshifts" /id="U1815" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.862137862137862" /psig=1 /xcortree=2560 /SigmaFactorBS="ctgtacaaactccttcaaaacaggatatgaaatagTATTGGA CgagagctttttggTGGCTTATACTATAGGGTAGccagtttttccggcaatgagagtg a" /listShort="scpA, spcB, ypuI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2122872..2122879) /Source="Nicolas_upshift_promotors" /id="U1815" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.862137862137862" /psig=1 /xcortree=2560 /SigmaFactorBS="ctgtacaaactccttcaaaacaggatatgaaatagTATTGGA CgagagctttttggTGGCTTATACTATAGGGTAGccagtttttccggcaatgagagtg a" /listShort="scpA, spcB, ypuI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2123019..2123026 /Source="Nicolas_upshift_promotors" /id="U1816" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2166 /SigmaFactorBS="tttcctttctaagaagcactagaggccgggcgttcttTTTTC CTTttatcccttcTATGGTACACTAAAAGCACAttaaaggaggaagcaccttgtatcc g" /listShort="ypuF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2123037..2123056 /Source="Nicolas_upshift_promotors" /id="U1816" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2166 /SigmaFactorBS="tttcctttctaagaagcactagaggccgggcgttcttTTTTC CTTttatcccttcTATGGTACACTAAAAGCACAttaaaggaggaagcaccttgtatcc g" /listShort="ypuF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2123042 /Source="Nicolas_upshifts" /id="U1816" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2166 /SigmaFactorBS="tttcctttctaagaagcactagaggccgggcgttcttTTTTC CTTttatcccttcTATGGTACACTAAAAGCACAttaaaggaggaagcaccttgtatcc g" /listShort="ypuF" /GFF_Attribute="listLong" /label="upshifts" CDS 2123074..2123598 /gene="ypuF" /locus_tag="BSU_23230" /old_locus_tag="BSU23230" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390204.1" /db_xref="EnsemblGenomes-Gn:BSU23230" /db_xref="EnsemblGenomes-Tr:CAB14255" /db_xref="InterPro:IPR005500" /db_xref="InterPro:IPR023203" /db_xref="SubtiList:BG10523" /db_xref="UniProtKB/Swiss-Prot:P17617" /translation="MYPKAYIDYLVEFHATRDYFECHEILEEYWKEDPPKKRKRYWVG FIQLAVALYHHRRQNTAGAKRLMANSIRILQAEHRAVEDLGLDHGRLLELMQSVYEQI ETVSAYKSIILPIKDEKLEEACRIECRKKKYTWGQPSALSNIFLIDKHRLRDRTDVIR EREKEIERRKKSRD*" /label="ypuF CDS" gene 2123074..2123598 /gene="ypuF" /locus_tag="BSU_23230" /old_locus_tag="BSU23230" /label="ypuF gene" CDS complement(2123612..2123986) /gene="ypzK" /locus_tag="BSU_23240" /old_locus_tag="BSU23240" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15466513, 25349719; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative riboflavin synthesis-related N-acetyltransferase" /protein_id="NP_390205.1" /db_xref="EnsemblGenomes-Gn:BSU23240" /db_xref="EnsemblGenomes-Tr:CAB14256" /db_xref="GOA:P17622" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG10522" /db_xref="UniProtKB/Swiss-Prot:P17622" /translation="MLIRYKKSFEKIAMGLLSFMPNEKDLKQLQQTIKDYETDTDRQL FLWKEDEDIVGAIGVEKKDSEVEIRHISVNPSHRHQGIGKQMMDALKHLFKTQVLVPN ELTQSFFERCQGQQDQDISYNN*" /label="ypzK CDS" gene complement(2123612..2123986) /gene="ypzK" /locus_tag="BSU_23240" /old_locus_tag="BSU23240" /label="ypzK gene" downshifts complement(2123628) /Source="Nicolas_upshifts" /id="D1216" /incds=0 /nref=264 /ntot=275 /MaxReadThrough="1.34496" /MaxDrop="8.09525" /score="39.5464967" /energy="-14.3" /TU="NA" /idTUdmin="U1817" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2124048..2124067) /Source="Nicolas_upshift_promotors" /id="U1817" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.601398601398601" /psig="0.993006993006993" /xcortree=420 /SigmaFactorBS="tttaaaccgctcatttgaataatttgctgaaaacAGTTTAAA aatatggcgaaAATGATATAATGTGAGAAAAcggatcacctattcgtatccgttaata g" /listShort="ypzK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2124060) /Source="Nicolas_upshifts" /id="U1817" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.601398601398601" /psig="0.993006993006993" /xcortree=420 /SigmaFactorBS="tttaaaccgctcatttgaataatttgctgaaaacAGTTTAAA aatatggcgaaAATGATATAATGTGAGAAAAcggatcacctattcgtatccgttaata g" /listShort="ypzK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2124079..2124086) /Source="Nicolas_upshift_promotors" /id="U1817" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.601398601398601" /psig="0.993006993006993" /xcortree=420 /SigmaFactorBS="tttaaaccgctcatttgaataatttgctgaaaacAGTTTAAA aatatggcgaaAATGATATAATGTGAGAAAAcggatcacctattcgtatccgttaata g" /listShort="ypzK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2124099..2124563) /gene="ribH" /locus_tag="BSU_23250" /old_locus_tag="BSU23250" /EC_number="2.5.1.78" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:3100522, 7473709, 10881048, 12456892, 24442413" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3100522, 7473709, 10881048, 12456892, 24442413; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="6,7-dimethyl-8-ribityllumazine synthase, beta subunit" /protein_id="NP_390206.1" /db_xref="EnsemblGenomes-Gn:BSU23250" /db_xref="EnsemblGenomes-Tr:CAB14257" /db_xref="GOA:P11998" /db_xref="InterPro:IPR002180" /db_xref="InterPro:IPR034964" /db_xref="InterPro:IPR036467" /db_xref="PDB:1RVV" /db_xref="PDB:1ZIS" /db_xref="SubtiList:BG10521" /db_xref="UniProtKB/Swiss-Prot:P11998" /translation="MNIIQGNLVGTGLKIGIVVGRFNDFITSKLLSGAEDALLRHGVD TNDIDVAWVPGAFEIPFAAKKMAETKKYDAIITLGTVIRGATTHYDYVCNEAAKGIAQ AANTTGVPVIFGIVTTENIEQAIERAGTKAGNKGVDCAVSAIEMANLNRSFE*" /label="ribH CDS" gene complement(2124099..2124563) /gene="ribH" /locus_tag="BSU_23250" /old_locus_tag="BSU23250" /label="ribH gene" promotor_-35 2124434..2124438 /Source="Nicolas_upshift_promotors" /id="U1818" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.974025974025974" /psig="0.000999000999001" /xcortree=35 /SigmaFactorBS="atgcgcctggaacccaagccacatcaatgtcatttgtgtCTA CGccatgtctgagcaGCGCAtcttctgctccgctcagcagcttgctcgtaataaaatc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2124452..2124456 /Source="Nicolas_upshift_promotors" /id="U1818" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.974025974025974" /psig="0.000999000999001" /xcortree=35 /SigmaFactorBS="atgcgcctggaacccaagccacatcaatgtcatttgtgtCTA CGccatgtctgagcaGCGCAtcttctgctccgctcagcagcttgctcgtaataaaatc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2124455 /Source="Nicolas_upshifts" /id="U1818" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.974025974025974" /psig="0.000999000999001" /xcortree=35 /SigmaFactorBS="atgcgcctggaacccaagccacatcaatgtcatttgtgtCTA CGccatgtctgagcaGCGCAtcttctgctccgctcagcagcttgctcgtaataaaatc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2124596..2125792) /gene="ribBA" /locus_tag="BSU_23260" /old_locus_tag="BSU23260" /EC_number="3.5.4.25" /EC_number="4.1.99.12" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9297088, 9515916, 12456892, 19583770, 24442413" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9297088, 9515916, 12456892, 19583770, 24442413; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fused 3,4-dihydroxy-2-butanone 4-phosphate synthase and GTP cyclohydrolase II" /protein_id="NP_390207.1" /db_xref="EnsemblGenomes-Gn:BSU23260" /db_xref="EnsemblGenomes-Tr:CAB14258" /db_xref="GOA:P17620" /db_xref="InterPro:IPR000422" /db_xref="InterPro:IPR000926" /db_xref="InterPro:IPR016299" /db_xref="InterPro:IPR017945" /db_xref="InterPro:IPR032677" /db_xref="InterPro:IPR036144" /db_xref="SubtiList:BG10520" /db_xref="UniProtKB/Swiss-Prot:P17620" /translation="MFHPIEEALDALKKGEVIIVVDDEDRENEGDFVALAEHATPEVI NFMATHGRGLICTPLSEEIADRLDLHPMVEHNTDSHHTAFTVSIDHRETKTGISAQER SFTVQALLDSKSVPSDFQRPGHIFPLIAKKGGVLKRAGHTEAAVDLAEACGSPGAGVI CEIMNEDGTMARVPELIEIAKKHQLKMITIKDLIQYRYNLTTLVEREVDITLPTDFGT FKVYGYTNEVDGKEHVAFVMGDVPFGEEPVLVRVHSECLTGDVFGSHRCDCGPQLHAA LNQIAAEGRGVLLYLRQEGRGIGLINKLKAYKLQEQGYDTVEANEALGFLPDLRNYGI GAQILRDLGVRNMKLLTNNPRKIAGLEGYGLSISERVPLQMEAKEHNKKYLQTKMNKL GHLLHF*" /label="ribBA CDS" gene complement(2124596..2125792) /gene="ribBA" /locus_tag="BSU_23260" /old_locus_tag="BSU23260" /label="ribBA gene" CDS complement(2125807..2126454) /gene="ribE" /locus_tag="BSU_23270" /old_locus_tag="BSU23270" /EC_number="2.5.1.9" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2106516, 12456892" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2106516, 12456892; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="riboflavin synthase (alpha subunit)" /protein_id="NP_390208.1" /db_xref="EnsemblGenomes-Gn:BSU23270" /db_xref="EnsemblGenomes-Tr:CAB14259" /db_xref="GOA:P16440" /db_xref="InterPro:IPR001783" /db_xref="InterPro:IPR017938" /db_xref="InterPro:IPR023366" /db_xref="InterPro:IPR026017" /db_xref="SubtiList:BG10519" /db_xref="UniProtKB/Swiss-Prot:P16440" /translation="MFTGIIEETGTIESMKKAGHAMALTIKCSKILEDVHLGDSIAVN GICLTVTDFTKNQFTVDVMPETVKATSLNDLTKGSKVNLERAMAANGRFGGHFVSGHV DGTAEITRIEEKSNAVYYDLKMDPSLTKTLVLKGSITVDGVSLTIFGLTEDTVTISLI PHTISETIFSEKTIGSKVNIECDMIGKYMYRFLHKANENKTQQTITKAFLSENGF*" /label="ribE CDS" gene complement(2125807..2126454) /gene="ribE" /locus_tag="BSU_23270" /old_locus_tag="BSU23270" /label="ribE gene" CDS complement(2126465..2127550) /gene="ribD" /locus_tag="BSU_23280" /old_locus_tag="BSU23280" /EC_number="1.1.1.193" /EC_number="3.5.4.26" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9068650, 12456892, 17765262, 18986985, 23385458" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9068650, 12456892, 17765262, 18986985, 23385458; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fused diaminohydroxyphosphoribosylaminopyrimidine deaminase; 5-amino-6-(5-phosphoribosylamino) uracil reductase" /protein_id="NP_390209.1" /db_xref="EnsemblGenomes-Gn:BSU23280" /db_xref="EnsemblGenomes-Tr:CAB14260" /db_xref="GOA:P17618" /db_xref="InterPro:IPR002125" /db_xref="InterPro:IPR002734" /db_xref="InterPro:IPR004794" /db_xref="InterPro:IPR011549" /db_xref="InterPro:IPR016192" /db_xref="InterPro:IPR016193" /db_xref="InterPro:IPR024072" /db_xref="PDB:2B3Z" /db_xref="PDB:2D5N" /db_xref="PDB:3EX8" /db_xref="PDB:4G3M" /db_xref="SubtiList:BG10518" /db_xref="UniProtKB/Swiss-Prot:P17618" /translation="MEEYYMKLALDLAKQGEGQTESNPLVGAVVVKDGQIVGMGAHLK YGEAHAEVHAIHMAGAHAEGADIYVTLEPCSHYGKTPPCAELIINSGIKRVFVAMRDP NPLVAGRGISMMKEAGIEVREGILADQAERLNEKFLHFMRTGLPYVTLKAAASLDGKI ATSTGDSKWITSEAARQDAQQYRKTHQSILVGVGTVKADNPSLTCRLPNVTKQPVRVI LDTVLSIPEDAKVICDQIAPTWIFTTARADEEKKKRLSAFGVNIFTLETERIQIPDVL KILAEEGIMSVYVEGGSAVHGSFVKEGCFQEIIFYFAPKLIGGTHAPSLISGEGFQSM KDVPLLQFTDITQIGRDIKLTAKPTKE*" /label="ribD CDS" gene complement(2126465..2127550) /gene="ribD" /locus_tag="BSU_23280" /old_locus_tag="BSU23280" /label="ribD gene" S_feature complement(2127551..2127679) /Source="Nicolas_S_feature" /locus_tag="new_2431344_2431472_c" /HighExp="T0.30H, B60, T1.30H, T2.0H, MG-0.2, T1.0H, S1, T0.0H, LPhT, T-0.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S881" misc_RNA complement(2127680..2127824) /gene="fswA" /locus_tag="BSU_misc_RNA_36" /product="flavin riboswitch" /experiment="publication(s) with functional evidences, PMID:12456892, 15808508, 17693491, 17997835" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12456892, 15808508, 17693491, 17997835; Product type n: RNA" /label="fswA RNA" gene complement(2127680..2127824) /gene="fswA" /locus_tag="BSU_misc_RNA_36" /label="fswA gene" promotor_-10 complement(2127841..2127860) /Source="Nicolas_upshift_promotors" /id="U1819" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.437562437562438" /psig="0.996003996003996" /xcortree=606 /SigmaFactorBS="tttgtttttctcaaattgtaagtttatttCATTGCGTacttt aaaaaggatCGCTATAATAACCAATAAGGacaaatgaataaagattgtatccttcggg g" /listShort="NA, S881, ribD, ribE, ribAB, ribH, ypzK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2127851) /Source="Nicolas_upshifts" /id="U1819" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.437562437562438" /psig="0.996003996003996" /xcortree=606 /SigmaFactorBS="tttgtttttctcaaattgtaagtttatttCATTGCGTacttt aaaaaggatCGCTATAATAACCAATAAGGacaaatgaataaagattgtatccttcggg g" /listShort="NA, S881, ribD, ribE, ribAB, ribH, ypzK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2127875..2127882) /Source="Nicolas_upshift_promotors" /id="U1819" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.437562437562438" /psig="0.996003996003996" /xcortree=606 /SigmaFactorBS="tttgtttttctcaaattgtaagtttatttCATTGCGTacttt aaaaaggatCGCTATAATAACCAATAAGGacaaatgaataaagattgtatccttcggg g" /listShort="NA, S881, ribD, ribE, ribAB, ribH, ypzK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2127944..2128288) /gene="ypuD" /locus_tag="BSU_23300" /old_locus_tag="BSU23300" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390211.1" /db_xref="EnsemblGenomes-Gn:BSU23300" /db_xref="EnsemblGenomes-Tr:CAB14262" /db_xref="SubtiList:BG10516" /db_xref="UniProtKB/Swiss-Prot:P17616" /translation="MGRIKTKITILLVLLLLLAGGYMYINDIELKDVPTAIGQTLSSE EEEYTIQEYKVTKIDGSEYHGVAENGTKIIFNGKKLNQDLSDIKEGDKIKAYFSKSKR IDGLIKVAKVND*" /label="ypuD CDS" gene complement(2127944..2128288) /gene="ypuD" /locus_tag="BSU_23300" /old_locus_tag="BSU23300" /label="ypuD gene" downshifts complement(2127959) /Source="Nicolas_upshifts" /id="D1217" /incds=0 /nref=78 /ntot=221 /MaxReadThrough="1.58771" /MaxDrop="5.14851" /score="20.5522057" /energy="-14.7" /TU="NA" /idTUdmin="U1820" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2128320..2128338) /Source="Nicolas_upshift_promotors" /id="U1820" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=749 /SigmaFactorBS="tgcatcgttatattaataatttacgagaatttacGGTTTTTt attcatgaaaaaaAGGAATAACTCATATGAATgaatagattcatattggctggaggtt t" /listShort="ypuD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2128333) /Source="Nicolas_upshifts" /id="U1820" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=749 /SigmaFactorBS="tgcatcgttatattaataatttacgagaatttacGGTTTTTt attcatgaaaaaaAGGAATAACTCATATGAATgaatagattcatattggctggaggtt t" /listShort="ypuD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2128347..2128352 /Source="Nicolas_upshift_promotors" /id="U1821" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1077 /SigmaFactorBS="tatgaatctattcattcatatgagttattcctttttttcaTG AATAaaaaaccgtaaattcTCGTAAATTATTAATATAAcgatgcataacgggaatatg t" /listShort="S882" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(2128353..2128359) /Source="Nicolas_upshift_promotors" /id="U1820" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=749 /SigmaFactorBS="tgcatcgttatattaataatttacgagaatttacGGTTTTTt attcatgaaaaaaAGGAATAACTCATATGAATgaatagattcatattggctggaggtt t" /listShort="ypuD" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2128367..2129289 /Source="Nicolas_S_feature" /locus_tag="new_2432160_2433082" /HighExp="S5, S4, S6, S8, S7, C30, S3, C90, BT, BC" /AntisenseName="sipS" /AntisenseCor="-0.46666993867379197" /AntisenseRegPval="-15.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S882" upshifts 2128367 /Source="Nicolas_upshifts" /id="U1821" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1077 /SigmaFactorBS="tatgaatctattcattcatatgagttattcctttttttcaTG AATAaaaaaccgtaaattcTCGTAAATTATTAATATAAcgatgcataacgggaatatg t" /listShort="S882" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2128368..2128386 /Source="Nicolas_upshift_promotors" /id="U1821" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1077 /SigmaFactorBS="tatgaatctattcattcatatgagttattcctttttttcaTG AATAaaaaaccgtaaattcTCGTAAATTATTAATATAAcgatgcataacgggaatatg t" /listShort="S882" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2128374..2128389) /Source="Nicolas_upshift_promotors" /id="U1822" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1641 /SigmaFactorBS="atagaaaagaaatttttgcagaaatgTGAAACATATtcccgt tatgcaTCGTTATATTAATAATttacgagaatttacggttttttattcatgaaaaaaa g" /listShort="ypuD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2128377) /Source="Nicolas_upshifts" /id="U1822" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1641 /SigmaFactorBS="atagaaaagaaatttttgcagaaatgTGAAACATATtcccgt tatgcaTCGTTATATTAATAATttacgagaatttacggttttttattcatgaaaaaaa g" /listShort="ypuD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2128379..2128445) /Source="Nicolas_S_feature" /locus_tag="new_2432172_2432238_c" /HighExp="Etha, T1.30H, M9-stat, T0.30H, M40t90, T2.30H, MG-0.2, MG 15, HiTm, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigI, SigA" /TUshortPSig="1, 0.994" /TUlongSig="SigA" /TUlongPSig="0.97" /label="S883" promotor_-35 complement(2128402..2128411) /Source="Nicolas_upshift_promotors" /id="U1822" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1641 /SigmaFactorBS="atagaaaagaaatttttgcagaaatgTGAAACATATtcccgt tatgcaTCGTTATATTAATAATttacgagaatttacggttttttattcatgaaaaaaa g" /listShort="ypuD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2128440..2128448) /Source="Nicolas_upshift_promotors" /id="U1823" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp=1 /psig=1 /xcortree=1769 /SigmaFactorBS="ttggggctgctttttttatatcttttttacggtcaTCCCCTA AAaacagaacataaaTTCGTATATctatagaaaagaaatttttgcagaaatgtgaaac a" /listShort="S883, ypuD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2128445) /Source="Nicolas_upshifts" /id="U1823" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp=1 /psig=1 /xcortree=1769 /SigmaFactorBS="ttggggctgctttttttatatcttttttacggtcaTCCCCTA AAaacagaacataaaTTCGTATATctatagaaaagaaatttttgcagaaatgtgaaac a" /listShort="S883, ypuD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2128462..2128470) /Source="Nicolas_upshift_promotors" /id="U1823" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp=1 /psig=1 /xcortree=1769 /SigmaFactorBS="ttggggctgctttttttatatcttttttacggtcaTCCCCTA AAaacagaacataaaTTCGTATATctatagaaaagaaatttttgcagaaatgtgaaac a" /listShort="S883, ypuD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2128523..2129077) /gene="sipS" /locus_tag="BSU_23310" /old_locus_tag="BSU23310" /EC_number="3.4.21.89" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:8282190, 9325333, 9694797, 9823656, 10198007, 10336490, 10982814, 11004175, 11309398, 15502345" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8282190, 9325333, 9694797, 9823656, 10198007, 10336490, 10982814, 11004175, 11309398, 15502345; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="type I signal peptidase" /protein_id="NP_390212.1" /db_xref="EnsemblGenomes-Gn:BSU23310" /db_xref="EnsemblGenomes-Tr:CAB14263" /db_xref="GOA:P28628" /db_xref="InterPro:IPR000223" /db_xref="InterPro:IPR015927" /db_xref="InterPro:IPR019756" /db_xref="InterPro:IPR019757" /db_xref="InterPro:IPR019758" /db_xref="InterPro:IPR036286" /db_xref="SubtiList:BG10515" /db_xref="UniProtKB/Swiss-Prot:P28628" /translation="MKSENVSKKKSILEWAKAIVIAVVLALLIRNFIFAPYVVDGDSM YPTLHNRERVFVNMTVKYIGEFDRGDIVVLNGDDVHYVKRIIGLPGDTVEMKNDQLYI NGKKVDEPYLAANKKRAKQDGFDHLTDDFGPVKVPDNKYFVMGDNRRNSMDSRNGLGL FTKKQIAGTSKFVFYPFNEMRKTN*" /label="sipS CDS" gene complement(2128523..2129077) /gene="sipS" /locus_tag="BSU_23310" /old_locus_tag="BSU23310" /label="sipS gene" downshifts complement(2128533) /Source="Nicolas_upshifts" /id="D1218" /incds=0 /nref=195 /ntot=252 /MaxReadThrough="3.6233" /MaxDrop="7.24702" /score="30.4586783" /energy="-10.9" /TU="U1824" /idTUdmin="U1825" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2129103..2129122) /Source="Nicolas_upshift_promotors" /id="U1824" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.901098901098901" /psig="0.994005994005994" /xcortree=3155 /SigmaFactorBS="atgaagattaacagtttgtaaaatcacttcaatggtcctaaT GGGATTttttttcgattCGTGATAACATAAATTGAAGaccgttgtttattggaggaaa t" /listShort="sipS, S883, ypuD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2129121) /Source="Nicolas_upshifts" /id="U1824" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.901098901098901" /psig="0.994005994005994" /xcortree=3155 /SigmaFactorBS="atgaagattaacagtttgtaaaatcacttcaatggtcctaaT GGGATTttttttcgattCGTGATAACATAAATTGAAGaccgttgtttattggaggaaa t" /listShort="sipS, S883, ypuD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2129123..2129522) /Source="Nicolas_S_feature" /locus_tag="new_2432916_2433315_c" /HighExp="T4.0H, T2.30H, T5.0H, T3.0H, T2.0H, T3.30H, M9-stat, C90, BC, T1.30H" /AntisenseName="ypzC" /AntisenseCor="-0.215992681600812" /AntisenseRegPval="-3.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.97" /TUlongSig="NA" /TUlongPSig="NA" /label="S884" promotor_-35 complement(2129134..2129140) /Source="Nicolas_upshift_promotors" /id="U1824" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.901098901098901" /psig="0.994005994005994" /xcortree=3155 /SigmaFactorBS="atgaagattaacagtttgtaaaatcacttcaatggtcctaaT GGGATTttttttcgattCGTGATAACATAAATTGAAGaccgttgtttattggaggaaa t" /listShort="sipS, S883, ypuD" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2129344..2129580 /gene="ypzC" /locus_tag="BSU_23320" /old_locus_tag="BSU23320" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_390213.1" /db_xref="EnsemblGenomes-Gn:BSU23320" /db_xref="EnsemblGenomes-Tr:CAB14264" /db_xref="SubtiList:BG13765" /db_xref="UniProtKB/Swiss-Prot:O32012" /translation="MFIYCIPLISQSMIPMALDKTINVMKVTGMFAATYFTGDNRTPF FAFIICLKSFKLENMDQPPKNKSNIFPAVEDSLL*" /label="ypzC CDS" gene 2129344..2129580 /gene="ypzC" /locus_tag="BSU_23320" /old_locus_tag="BSU23320" /label="ypzC gene" CDS complement(2129523..2129729) /gene="ypzJ" /locus_tag="BSU_23328" /old_locus_tag="BSU23328" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097757.1" /db_xref="EnsemblGenomes-Gn:BSU23328" /db_xref="EnsemblGenomes-Tr:CAX52656" /db_xref="InterPro:IPR018652" /db_xref="UniProtKB/Swiss-Prot:C0H447" /translation="MNNKGCIKCGSTEAGQKEIATTGTGLSKLFDVQHNRFLVVYCKN CGYSEFYNKESSTAGNILDLFFGG*" /label="ypzJ CDS" gene complement(2129523..2129729) /gene="ypzJ" /locus_tag="BSU_23328" /old_locus_tag="BSU23328" /label="ypzJ gene" misc_feature complement(2129762..2129781) /Source="Nicolas_upshift_promotors" /id="U1825" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.440559440559441" /psig="0.97002997002997" /xcortree=2780 /SigmaFactorBS="caattagtatgtaatcaaaattaagtaaactttaaagtagta cgggtcattgggattgatattTTGTAGTAAAATAAATCAAAcaaacgtgatgtaatga a" /listShort="ypzJ, S884, sipS" /listLong="S883, ypuD" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2129784) /Source="Nicolas_upshifts" /id="U1825" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.440559440559441" /psig="0.97002997002997" /xcortree=2780 /SigmaFactorBS="caattagtatgtaatcaaaattaagtaaactttaaagtagta cgggtcattgggattgatattTTGTAGTAAAATAAATCAAAcaaacgtgatgtaatga a" /listShort="ypzJ, S884, sipS" /listLong="S883, ypuD" /label="upshifts" CDS complement(2129838..2130092) /gene="ypuC" /locus_tag="BSU_23329" /old_locus_tag="BSU23329" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="fragment of hypothetical protein" /db_xref="PSEUDO:CAX52657.1" /translation="MSFLVFVLIFLFVILTRRVCKLLHFFVYYRFIPHRAEPCVLYEQ YPSDVAAGYAFGGVWLSLNVLVMELFRFSRRFTKLRNEPN*" /label="ypuC CDS" gene complement(2129838..2130092) /gene="ypuC" /locus_tag="BSU_23329" /old_locus_tag="BSU23329" /pseudo /label="ypuC gene" promotor_-35 2129972..2129981 /Source="Nicolas_upshift_promotors" /id="U1826" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1336 /SigmaFactorBS="taacccgcagcaacatcactcggatactgctcataaaGTACA CACGGctcagcccgatgaGGAATAAAACGATAATAAACaaaaaaatgcaacagtttgc a" /listShort="S885" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2129983..2130372) /gene="ypuC" /locus_tag="BSU_23330" /old_locus_tag="BSU23330" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 15849754, 16850406" /pseudo /codon_start=1 /transl_table=11 /product="fragment of hypothetical protein" /db_xref="SubtiList:BG10514" /translation="MSYWIGYRLGPAAIQKAFASRGVLLAVIVLTFFWTVFRGQDRKI ELSFLFFLVIGGELYEEGIRRLFHSLHPVHAPLESHVLYPFPSEQTLTAFVIFGFCAY LFVRHSHKTRLQTVAFFCLLSFYSSSG*" /label="ypuC CDS" gene complement(2129983..2130372) /gene="ypuC" /locus_tag="BSU_23330" /old_locus_tag="BSU23330" /pseudo /label="ypuC gene" S_feature 2129995..2131066 /Source="Nicolas_S_feature" /locus_tag="new_2433788_2434859" /HighExp="S6, S8, S7, BT, S5, B36, S4, Pyr, G/S, C30" /AntisenseName="ypuC" /AntisenseCor="0.37168085148262697" /AntisenseRegPval="-9.5" /CDS_PredictionProba="0.69113899999999995" /TUshortSig="SigK" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S885" promotor_-10 2129995..2130014 /Source="Nicolas_upshift_promotors" /id="U1826" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1336 /SigmaFactorBS="taacccgcagcaacatcactcggatactgctcataaaGTACA CACGGctcagcccgatgaGGAATAAAACGATAATAAACaaaaaaatgcaacagtttgc a" /listShort="S885" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2129995 /Source="Nicolas_upshifts" /id="U1826" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1336 /SigmaFactorBS="taacccgcagcaacatcactcggatactgctcataaaGTACA CACGGctcagcccgatgaGGAATAAAACGATAATAAACaaaaaaatgcaacagtttgc a" /listShort="S885" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2130350..2130553) /gene="ypuB" /locus_tag="BSU_23340" /old_locus_tag="BSU23340" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_390215.1" /db_xref="EnsemblGenomes-Gn:BSU23340" /db_xref="EnsemblGenomes-Tr:CAB14266" /db_xref="SubtiList:BG10513" /db_xref="UniProtKB/Swiss-Prot:P35151" /translation="MQVLTGLLEQYGYAVLFIVLMLELLALLGPGEFAGVLVFQEKLN WVLSMLAAGLGSCGSEHVVLDRV*" /label="ypuB CDS" gene complement(2130350..2130553) /gene="ypuB" /locus_tag="BSU_23340" /old_locus_tag="BSU23340" /label="ypuB gene" CDS 2130962..2131078 /locus_tag="BSU_23349" /old_locus_tag="BSU23349" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="PSEUDO:SOX90572.1" /translation="MYMHFESAQDDPITFARKAAAAFRVVKRIDRYLGFRKL*" /label="hypothetical protein CDS" gene 2130962..2131078 /locus_tag="BSU_23349" /old_locus_tag="BSU23349" /pseudo /label="gene" downshifts 2131029 /Source="Nicolas_upshifts" /id="D1219" /incds=0 /nref=3 /ntot=18 /MaxReadThrough="-0.179729999999999" /MaxDrop="3.76747" /score="-7.5033349" /energy="-9.1" /TU="NA" /idTUdmin="U1826" /TUdmin=198 /isTUend="FALSE" /label="downshifts" promotor_-35 2131155..2131164 /Source="Nicolas_upshift_promotors" /id="U1827" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1416 /SigmaFactorBS="aaacaggcatctcctaaatatttttgccgataagtttaCGCT AATCAActctagcactaaTACATATAAAAAATAGAATGatatgaaaggagacttgata g" /listShort="ypzD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2131177..2131196 /Source="Nicolas_upshift_promotors" /id="U1827" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1416 /SigmaFactorBS="aaacaggcatctcctaaatatttttgccgataagtttaCGCT AATCAActctagcactaaTACATATAAAAAATAGAATGatatgaaaggagacttgata g" /listShort="ypzD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2131177 /Source="Nicolas_upshifts" /id="U1827" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1416 /SigmaFactorBS="aaacaggcatctcctaaatatttttgccgataagtttaCGCT AATCAActctagcactaaTACATATAAAAAATAGAATGatatgaaaggagacttgata g" /listShort="ypzD" /GFF_Attribute="listLong" /label="upshifts" CDS 2131219..2131431 /gene="ypzD" /locus_tag="BSU_23350" /old_locus_tag="BSU23350" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative germination protein" /protein_id="NP_390216.1" /db_xref="EnsemblGenomes-Gn:BSU23350" /db_xref="EnsemblGenomes-Tr:CAB14267" /db_xref="InterPro:IPR019618" /db_xref="SubtiList:BG13766" /db_xref="UniProtKB/Swiss-Prot:O32013" /translation="MIDYPININNVSGNSVINVGGAFMIRPLTLSKSVFGSGGLNTGI VFENNFVSKAKMINHQFTDQNVTKTF*" /label="ypzD CDS" gene 2131219..2131431 /gene="ypzD" /locus_tag="BSU_23350" /old_locus_tag="BSU23350" /label="ypzD gene" downshifts 2131425 /Source="Nicolas_upshifts" /id="D1220" /incds=0 /nref=4 /ntot=32 /MaxReadThrough="4.9048" /MaxDrop="3.6863" /score="3.56038753" /energy="-6.9" /TU="U1827" /idTUdmin="U1827" /TUdmin="-264" /isTUend="FALSE" /label="downshifts" downshifts complement(2131567) /Source="Nicolas_upshifts" /id="D1221" /incds=0 /nref=254 /ntot=263 /MaxReadThrough="2.52018" /MaxDrop="8.47213" /score="34.3429406" /energy="-12.4" /TU="NA" /idTUdmin="U1828" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2131567..2131998) /gene="ppiB" /locus_tag="BSU_23360" /old_locus_tag="BSU23360" /EC_number="5.2.1.8" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:8639516, 9063446, 9748346, 25184565" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8639516, 9063446, 9748346, 25184565; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peptidyl-prolyl isomerase" /protein_id="NP_390217.1" /db_xref="EnsemblGenomes-Gn:BSU23360" /db_xref="EnsemblGenomes-Tr:CAB14268" /db_xref="GOA:P35137" /db_xref="InterPro:IPR002130" /db_xref="InterPro:IPR020892" /db_xref="InterPro:IPR024936" /db_xref="InterPro:IPR029000" /db_xref="SubtiList:BG10512" /db_xref="UniProtKB/Swiss-Prot:P35137" /translation="MKTGYFLLEDGNKIEFELYPEAAPGTVANFEKLANEGFYDGLTF HRVIPGFVSQGGCPHGTGTGGPGYTIKCETEGNPHTHEAGALSMAHAGKDTGGSQFFI VHEPQPHLNGVHTVFGKVTSGLEFAKNMSNGDVMKEVRVEG*" /label="ppiB CDS" gene complement(2131567..2131998) /gene="ppiB" /locus_tag="BSU_23360" /old_locus_tag="BSU23360" /label="ppiB gene" S_feature complement(2131999..2132085) /Source="Nicolas_S_feature" /locus_tag="new_2435792_2435878_c" /HighExp="dia5, dia15, dia0, Lbexp, LBGtran, C90, Lbtran, HPh, G180, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S886" promotor_-10 complement(2132068..2132087) /Source="Nicolas_upshift_promotors" /id="U1828" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.643356643356643" /psig=1 /xcortree=2355 /SigmaFactorBS="ttcaggtttcatttttattttttagtaaagctcgggagaTTC GTTttcccccgaaaggTGTGGTATAATAGCCGCGACaaggagagacaggctataacct a" /listShort="S886, ppiB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2132085) /Source="Nicolas_upshifts" /id="U1828" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.643356643356643" /psig=1 /xcortree=2355 /SigmaFactorBS="ttcaggtttcatttttattttttagtaaagctcgggagaTTC GTTttcccccgaaaggTGTGGTATAATAGCCGCGACaaggagagacaggctataacct a" /listShort="S886, ppiB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2132101..2132106) /Source="Nicolas_upshift_promotors" /id="U1828" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.643356643356643" /psig=1 /xcortree=2355 /SigmaFactorBS="ttcaggtttcatttttattttttagtaaagctcgggagaTTC GTTttcccccgaaaggTGTGGTATAATAGCCGCGACaaggagagacaggctataacct a" /listShort="S886, ppiB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2132135..2132144 /Source="Nicolas_upshift_promotors" /id="U1829" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1655 /SigmaFactorBS="gggggaaaacgaatctcccgagctttactaaaaaataaaaaT GAAACCTGAatctctttatctCCGTCTAACCTAACGGaactgtatttttcatgattca g" /listShort="S887, ypuA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2132154..2132251 /Source="Nicolas_S_feature" /locus_tag="new_2435947_2436044" /HighExp="Heat, Etha, Salt, dia0, HiTm, T0.30H, B60, Lbexp, T1.0H, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S887" upshifts 2132154 /Source="Nicolas_upshifts" /id="U1829" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1655 /SigmaFactorBS="gggggaaaacgaatctcccgagctttactaaaaaataaaaaT GAAACCTGAatctctttatctCCGTCTAACCTAACGGaactgtatttttcatgattca g" /listShort="S887, ypuA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2132157..2132172 /Source="Nicolas_upshift_promotors" /id="U1829" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1655 /SigmaFactorBS="gggggaaaacgaatctcccgagctttactaaaaaataaaaaT GAAACCTGAatctctttatctCCGTCTAACCTAACGGaactgtatttttcatgattca g" /listShort="S887, ypuA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2132252..2133124 /gene="ypuA" /locus_tag="BSU_23370" /old_locus_tag="BSU23370" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17434969, 18179421, 24706874; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_390218.1" /db_xref="EnsemblGenomes-Gn:BSU23370" /db_xref="EnsemblGenomes-Tr:CAB14269" /db_xref="InterPro:IPR009343" /db_xref="SubtiList:BG10511" /db_xref="UniProtKB/Swiss-Prot:P31847" /translation="MKKIWIGMLAAAVLLLMVPKVSLADAAVGDVIVTLGADLSESDK QKVLDEMNVPDNATTVTVTNKEEHEYLGKYISNAQIGSRAISSSSITIAKKGSGLNVE THNISGITDEMYLNALMTAGVKDAKVYVTAPFEVSGTAALTGLIKAYEVSSDEAISED VKQVANQELVTTSELGDKIGNENAAALIAKIKEEFAKNGVPDNKADIEKQVDDAASDL NVTLTDSQKNQLVSLFNKMKNADIDWGQVSDQLDKAKDKITKFIESDEGKNFIQKVID FFVSIWNAIVSIFK*" /label="ypuA CDS" gene 2132252..2133124 /gene="ypuA" /locus_tag="BSU_23370" /old_locus_tag="BSU23370" /label="ypuA gene" downshifts 2133031 /Source="Nicolas_upshifts" /id="D1222" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="5.9994" /MaxDrop="4.15288" /score="27.7277161" /energy="-12.7" /TU="U1829" /idTUdmin="U1829" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" downshifts 2133097 /Source="Nicolas_upshifts" /id="D1223" /incds=0 /nref=104 /ntot=219 /MaxReadThrough="1.98749" /MaxDrop="5.95835" /score="27.7277161" /energy="-12.7" /TU="NA" /idTUdmin="U1829" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2133154..2134473) /gene="lysA" /locus_tag="BSU_23380" /old_locus_tag="BSU23380" /EC_number="4.1.1.20" /experiment="publication(s) with functional evidences, PMID:9044297, 14627808" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9044297, 14627808; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="meso-2,6-diaminopimelate decarboxylase" /protein_id="NP_390219.1" /db_xref="EnsemblGenomes-Gn:BSU23380" /db_xref="EnsemblGenomes-Tr:CAB14270" /db_xref="GOA:P23630" /db_xref="InterPro:IPR000183" /db_xref="InterPro:IPR002986" /db_xref="InterPro:IPR009006" /db_xref="InterPro:IPR022643" /db_xref="InterPro:IPR022644" /db_xref="InterPro:IPR022653" /db_xref="InterPro:IPR022657" /db_xref="InterPro:IPR029066" /db_xref="SubtiList:BG10510" /db_xref="UniProtKB/Swiss-Prot:P23630" /translation="MFLHGTSRQNQHGHLEIGGVDALYLAEKYGTPLYVYDVALIRER AKSFKQAFISAGLKAQVAYASKAFSSVAMIQLAEEEGLSLDVVSGGELYTAVAAGFPA ERIHFHGNNKSREELRMALEHRIGCIVVDNFYEIALLEDLCKETGHSIDVLLRITPGV EAHTHDYITTGQEDSKFGFDLHNGQTERAIEQVLQSEHIQLLGVHCHIGSQIFDTAGF VLAAEKIFKKLDEWRDSYSFVSKVLNLGGGFGIRYTEDDEPLHATEYVEKIIEAVKEN ASRYGFDIPEIWIEPGRSLVGDAGTTLYTVGSQKEVPGVRQYVAVDGGMNDNIRPALY QAKYEAAAANRIGEAHDKTVSIAGKCCESGDMLIWDIDLPEVKEGDLLAVFCTGAYGY SMANNYNRIPRPAVVFVENGEAHLVVKRETYEDIVKLDLPFKTGVKQ*" /label="lysA CDS" gene complement(2133154..2134473) /gene="lysA" /locus_tag="BSU_23380" /old_locus_tag="BSU23380" /label="lysA gene" downshifts complement(2133174) /Source="Nicolas_upshifts" /id="D1224" /incds=0 /nref=192 /ntot=251 /MaxReadThrough="2.99445" /MaxDrop="5.13504" /score="28.6775009" /energy="-12.7" /TU="NA" /idTUdmin="U1830" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2134474..2134538) /Source="Nicolas_S_feature" /locus_tag="new_2438267_2438331_c" /HighExp="C90, HiOs, BMM, GM 120, GM 25, MG-0.2, GM 15, GM-0.2, MG t5, MG 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF" /TUshortPSig="0.996, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S888" promotor_-10 complement(2134534..2134553) /Source="Nicolas_upshift_promotors" /id="U1830" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.711288711288711" /psig="0.996003996003996" /xcortree=3075 /SigmaFactorBS="ggcagcctaccaattcataatcgCATTGAAActgactgaaga gtaTGATAATGTATGTCTTAATTatgaagggacagtccataaaactgtcctttcatcc a" /listShort="S888, lysA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2134538) /Source="Nicolas_upshifts" /id="U1830" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.711288711288711" /psig="0.996003996003996" /xcortree=3075 /SigmaFactorBS="ggcagcctaccaattcataatcgCATTGAAActgactgaaga gtaTGATAATGTATGTCTTAATTatgaagggacagtccataaaactgtcctttcatcc a" /listShort="S888, lysA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2134568..2134575) /Source="Nicolas_upshift_promotors" /id="U1830" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.711288711288711" /psig="0.996003996003996" /xcortree=3075 /SigmaFactorBS="ggcagcctaccaattcataatcgCATTGAAActgactgaaga gtaTGATAATGTATGTCTTAATTatgaagggacagtccataaaactgtcctttcatcc a" /listShort="S888, lysA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2134579..2136060) /gene="spoVAF" /locus_tag="BSU_23390" /old_locus_tag="BSU23390" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:16077113, 17573930, 24682327, 26604257" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16077113, 17573930, 24682327, 26604257; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage V sporulation protein AF" /protein_id="NP_390220.2" /db_xref="EnsemblGenomes-Gn:BSU23390" /db_xref="EnsemblGenomes-Tr:CAB14271" /db_xref="GOA:P31845" /db_xref="InterPro:IPR004995" /db_xref="SubtiList:BG10508" /db_xref="UniProtKB/Swiss-Prot:P31845" /translation="MPDHKEEKIRVYRNPAKNEEYFKNRVGMGTSYDVGVRKLTILDK EIQLYYLNGLCDTAYIIHLMRELVAINNRKEDPDELVDIVENRLLNAQVEKVKTLDET TDQVLSGLVAVIVEGAGFAFIIDVRSYPGRNPEEPDTEKVVRGARDGFVENIVVNTAL LRRRIRDERLRVKMTKVGERSKTDLSICYIEDIADPDLVEIVEKEIASIDVDGLTMAD KTVEEFIVNQSYNPFPLVRYTERPDVAANHVLEGHVIIIVDTSPSVIITPTTLFHHVQ HAEEYRQAPSVGTFLRWVRFFGILASTLFLPIWFLFVLQPDLLPDNMKFIGLNKDTHI PIILQIFLADLGIEFLRMAAIHTPTALSTAMGLIAAVLIGQIAIEVGLFSPEVILYVS LAAIGTFTTPSYELSLANKMSRLVLMILVALFHIKGLVIGFTVLIIAMASIKSLQTPY LWPLIPFNGKALWQVLVRTAKPGAKVRPSIVHPKNRLRQPTNS*" /label="spoVAF CDS" gene complement(2134579..2136060) /gene="spoVAF" /locus_tag="BSU_23390" /old_locus_tag="BSU23390" /label="spoVAF gene" misc_feature complement(2135285..2135304) /Source="Nicolas_upshift_promotors" /id="U1831" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.95004995004995" /psig="0.998001998001998" /xcortree=2143 /SigmaFactorBS="tatacagaaagaccggatgtggccgcaaatcatgttctagaa ggcCATGTTATCATTATAGTGGAcacatcgccgagtgtgatcattaccccgacgactt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2135289) /Source="Nicolas_upshifts" /id="U1831" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.95004995004995" /psig="0.998001998001998" /xcortree=2143 /SigmaFactorBS="tatacagaaagaccggatgtggccgcaaatcatgttctagaa ggcCATGTTATCATTATAGTGGAcacatcgccgagtgtgatcattaccccgacgactt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2136011..2136622) /gene="spoVAEA" /locus_tag="BSU_23401" /old_locus_tag="BSU23401" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:16077113, 17573930, 24682327, 26604257" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16077113, 17573930, 24682327, 26604257; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage V sporulation germinant protein" /protein_id="YP_003097758.1" /db_xref="EnsemblGenomes-Gn:BSU23401" /db_xref="EnsemblGenomes-Tr:CAX52658" /db_xref="GOA:P40870" /db_xref="InterPro:IPR025914" /db_xref="UniProtKB/Swiss-Prot:P40870" /translation="MTTKRKVILVTDGDVYAAKTIEYAASKVGGRCISQSKGNPSTRS GAELVKLIASAPYDPVFVMFDDSGLQGEGPGEAALTYVATHPSIEVLGVIAVASKTHQ AEWTRVDVSIDRNGEITEYGVDKVGEREFDDHRMSGDTVYCLDKLDLPLIVGIGDIGK MGRKDDISKGSPITMKAVEFILERSGYHAGPQGRENSGLSESS*" /label="spoVAEA CDS" gene complement(2136011..2136622) /gene="spoVAEA" /locus_tag="BSU_23401" /old_locus_tag="BSU23401" /label="spoVAEA gene" CDS complement(2136630..2136980) /gene="spoVAEB" /locus_tag="BSU_23402" /old_locus_tag="BSU23402" /experiment="publication(s) with functional evidences, PMID:17573930, 26604257, 27105070" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17573930, 26604257, 27105070; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germinant protein" /protein_id="YP_003097759.1" /db_xref="EnsemblGenomes-Gn:BSU23402" /db_xref="EnsemblGenomes-Tr:CAX52659" /db_xref="GOA:C0H450" /db_xref="InterPro:IPR005562" /db_xref="InterPro:IPR014204" /db_xref="UniProtKB/Swiss-Prot:C0H450" /translation="MDYLLAFVCGGAICIVGQLLLDIFKLTPAHVMTSFVVIGAILDG FGIYDKFIEFAGGGATVPIVSFGHSLLHGAMHQAHIHGFIGIGMGIFELTSAGISAAI LFAFIVAVIFKPKG*" /label="spoVAEB CDS" gene complement(2136630..2136980) /gene="spoVAEB" /locus_tag="BSU_23402" /old_locus_tag="BSU23402" /label="spoVAEB gene" CDS complement(2136982..2137998) /gene="spoVAD" /locus_tag="BSU_23410" /old_locus_tag="BSU23410" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:16077113, 22328679, 26604257, 27105070" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16077113, 22328679, 26604257, 27105070; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage V sporulation protein AD (uptake of pyridine-2,6-dicarboxylic acid)" /protein_id="NP_390222.1" /db_xref="EnsemblGenomes-Gn:BSU23410" /db_xref="EnsemblGenomes-Tr:CAB14273" /db_xref="GOA:P40869" /db_xref="InterPro:IPR010894" /db_xref="InterPro:IPR016039" /db_xref="PDB:3LM6" /db_xref="SubtiList:BG10895" /db_xref="UniProtKB/Swiss-Prot:P40869" /translation="MKLTGKQTWVFEHPIFVNSAGTAAGPKEKDGPLGSLFDKTYDEM HCNQKSWEMAERQLMEDAVNVALQKNNLTKDDIDLLLAGDLLNQNVTANYVARHLKIP FLCMFGACSTSMETVAVASALVDGGFAKRALAATSSHNATAERQFRYPTEYGGQKPDT ATSTVTGSGAVVISQTPGDIQITSATVGKVSDLGITDPFDMGSAMAPAAADTIKQHFK DLNRTADDYDLILTGDLSGVGSPIVKDILKEDGYPVGTKHDDCGLLIYTPDQQVFAGG SGCACSAVVTYSHIFKQLREGKLNRVFVVATGALLSPTMIQQKETIPTIAHGVVFERA GGAS*" /label="spoVAD CDS" gene complement(2136982..2137998) /gene="spoVAD" /locus_tag="BSU_23410" /old_locus_tag="BSU23410" /label="spoVAD gene" promotor_-35 2137478..2137485 /Source="Nicolas_upshift_promotors" /id="U1832" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.711288711288711" /psig="0.987012987012987" /xcortree=627 /SigmaFactorBS="tatcacccggtgtctgaCTGATGACaactgcaccgcttCCGG TTACAGTGGAGGTAGCagtgtccggtttttggcctccgtattctgtcggatagcgaaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2137499..2137518 /Source="Nicolas_upshift_promotors" /id="U1832" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.711288711288711" /psig="0.987012987012987" /xcortree=627 /SigmaFactorBS="tatcacccggtgtctgaCTGATGACaactgcaccgcttCCGG TTACAGTGGAGGTAGCagtgtccggtttttggcctccgtattctgtcggatagcgaaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2137521 /Source="Nicolas_upshifts" /id="U1832" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.711288711288711" /psig="0.987012987012987" /xcortree=627 /SigmaFactorBS="tatcacccggtgtctgaCTGATGACaactgcaccgcttCCGG TTACAGTGGAGGTAGCagtgtccggtttttggcctccgtattctgtcggatagcgaaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2138011..2138463) /gene="spoVAC" /locus_tag="BSU_23420" /old_locus_tag="BSU23420" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15849754, 16077113, 16850406, 24666282, 26604257, 27105070" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16077113, 16850406, 24666282, 26604257, 27105070; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="mechanosensitive channel; stage V sporulation protein AC" /protein_id="NP_390223.1" /db_xref="EnsemblGenomes-Gn:BSU23420" /db_xref="EnsemblGenomes-Tr:CAB14274" /db_xref="GOA:P40868" /db_xref="InterPro:IPR005562" /db_xref="InterPro:IPR014203" /db_xref="SubtiList:BG10894" /db_xref="UniProtKB/Swiss-Prot:P40868" /translation="MTNIKENYKSKVKTYQPKPPYVWNCVKAFLVGGLICAIGQGLQN FYIHFFDFNEKTAGNPTAATLILISALLTGFGIYDRIGQFAGAGSAVPVTGFANSMAS AALEYKSEGLVLGVATNMFKLAGNVIVFGVVAAYIVGMIRFAFEKLMS*" /label="spoVAC CDS" gene complement(2138011..2138463) /gene="spoVAC" /locus_tag="BSU_23420" /old_locus_tag="BSU23420" /label="spoVAC gene" CDS complement(2138476..2138901) /gene="spoVAB" /locus_tag="BSU_23430" /old_locus_tag="BSU23430" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15849754, 16077113, 16850406, 26604257" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16077113, 16850406, 26604257; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage V sporulation protein AB" /protein_id="NP_390224.1" /db_xref="EnsemblGenomes-Gn:BSU23430" /db_xref="EnsemblGenomes-Tr:CAB14275" /db_xref="GOA:P40867" /db_xref="InterPro:IPR020144" /db_xref="SubtiList:BG10893" /db_xref="UniProtKB/Swiss-Prot:P40867" /translation="MIVSVLFIIFVGLGGGITVGAGFVAFLTVMGIIPRLMQLTKTMR FVQAYEAAVILGAVCGGWETLHMNHLYLTKWIAVPVGLLAGLFVGMLAAALTEVLNVL PILAKRIGLRSKIIILLMAIVIGKIAGSLFHWLYFIDHS*" /label="spoVAB CDS" gene complement(2138476..2138901) /gene="spoVAB" /locus_tag="BSU_23430" /old_locus_tag="BSU23430" /label="spoVAB gene" CDS complement(2138891..2139511) /gene="spoVAA" /locus_tag="BSU_23440" /old_locus_tag="BSU23440" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:3114420, 26604257" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3114420, 26604257; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage V sporulation protein AA" /protein_id="NP_390225.2" /db_xref="EnsemblGenomes-Gn:BSU23440" /db_xref="EnsemblGenomes-Tr:CAB14276" /db_xref="GOA:P40866" /db_xref="InterPro:IPR021997" /db_xref="SubtiList:BG10892" /db_xref="UniProtKB/Swiss-Prot:P40866" /translation="MERRIFIRLRHRVLAHPGDIITVGDAAQIEGQLQLKKKLSAMPL YQVSEKDKNIVILDIIQVLRAIHLQDPTIDVQTVGGAETIVEIQYRKRNLSTVLFIGV WLLLFIGSCLAIMNFHEDVSMRDVHIALYEIITGERNDYPYLLQIPYSIGLGLGMIVF FNHIFKKRLNEEPSPLEVEMFNYQLDLDQYVAMHENQETIKDLHDR*" /label="spoVAA CDS" gene complement(2138891..2139511) /gene="spoVAA" /locus_tag="BSU_23440" /old_locus_tag="BSU23440" /label="spoVAA gene" promotor_-10 complement(2139542..2139553) /Source="Nicolas_upshift_promotors" /id="U1833" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=924 /SigmaFactorBS="tgtgcaaaagcgtggtaatttatggtcttttcgagcggaTGA ATGAgaacaaaatcgaaCCACATACTACAtatataaccaccgaaagatggtgatcaat g" /listShort="spoVAA, spoVAB, spoVAC, spoVAD, spoVAEB, spoVAEA, spoVAF, S888, lysA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2139552) /Source="Nicolas_upshifts" /id="U1833" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=924 /SigmaFactorBS="tgtgcaaaagcgtggtaatttatggtcttttcgagcggaTGA ATGAgaacaaaatcgaaCCACATACTACAtatataaccaccgaaagatggtgatcaat g" /listShort="spoVAA, spoVAB, spoVAC, spoVAD, spoVAEB, spoVAEA, spoVAF, S888, lysA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2139567..2139573) /Source="Nicolas_upshift_promotors" /id="U1833" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=924 /SigmaFactorBS="tgtgcaaaagcgtggtaatttatggtcttttcgagcggaTGA ATGAgaacaaaatcgaaCCACATACTACAtatataaccaccgaaagatggtgatcaat g" /listShort="spoVAA, spoVAB, spoVAC, spoVAD, spoVAEB, spoVAEA, spoVAF, S888, lysA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2139636..2140403) /gene="sigF" /locus_tag="BSU_23450" /old_locus_tag="BSU23450" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9891799, 15187183, 15205417, 15819616, 16045607, 22115775, 23169620, 24067622, 26506528" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9891799, 15187183, 15205417, 15819616, 16045607, 22115775, 23169620, 24067622, 26506528; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="RNA polymerase sporulation-specific sigma factor(sigma-F)" /protein_id="NP_390226.1" /db_xref="EnsemblGenomes-Gn:BSU23450" /db_xref="EnsemblGenomes-Tr:CAB14277" /db_xref="GOA:P07860" /db_xref="InterPro:IPR000943" /db_xref="InterPro:IPR007624" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR007630" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014236" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR014322" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10298" /db_xref="UniProtKB/Swiss-Prot:P07860" /translation="MDVEVKKNGKNAQLKDHEVKELIKQSQNGDQQARDLLIEKNMRL VWSVVQRFLNRGYEPDDLFQIGCIGLLKSVDKFDLTYDVRFSTYAVPMIIGEIQRFIR DDGTVKVSRSLKELGNKIRRAKDELSKTLGRVPTVQEIADHLEIEAEDVVLAQEAVRA PSSIHETVYENDGDPITLLDQIADNSEEKWFDKIALKEAISDLEEREKLIVYLRYYKD QTQSEVAERLGISQVQVSRLEKKILKQIKVQMDHTDG*" /label="sigF CDS" gene complement(2139636..2140403) /gene="sigF" /locus_tag="BSU_23450" /old_locus_tag="BSU23450" /label="sigF gene" downshifts complement(2139666) /Source="Nicolas_upshifts" /id="D1225" /incds=0 /nref=89 /ntot=197 /MaxReadThrough="1.81932" /MaxDrop="7.16571" /score="21.6169221" /energy="-13.5" /TU="NA" /idTUdmin="U1834" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(2140415..2140855) /gene="spoIIAB" /locus_tag="BSU_23460" /old_locus_tag="BSU23460" /EC_number="2.7.11.-" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15023063, 15187183, 15819616, 16166546, 16824103, 22115775" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15023063, 15187183, 15819616, 16166546, 16824103, 22115775; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="anti-sigma factor (antagonist of sigma(F)) and serine kinase" /protein_id="NP_390227.1" /db_xref="EnsemblGenomes-Gn:BSU23460" /db_xref="EnsemblGenomes-Tr:CAB14278" /db_xref="GOA:P10728" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR010194" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG10297" /db_xref="UniProtKB/Swiss-Prot:P10728" /translation="MKNEMHLEFSALSQNESFARVTVASFIAQLDPTMDELTEIKTVV SEAVTNAIIHGYEENCEGKVYISVTLEDHVVYMTIRDEGLGITDLEEARQPLFTTKPE LERSGMGFTIMENFMDDVSIDSSPEMGTTIRLTKHLSKSKALCN*" /label="spoIIAB CDS" gene complement(2140415..2140855) /gene="spoIIAB" /locus_tag="BSU_23460" /old_locus_tag="BSU23460" /label="spoIIAB gene" CDS complement(2140852..2141205) /gene="spoIIAA" /locus_tag="BSU_23470" /old_locus_tag="BSU23470" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11173484, 15819616, 16824103, 22115775" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11173484, 15819616, 16824103, 22115775; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="anti-anti-sigma factor (antagonist of SpoIIAB)" /protein_id="NP_390228.1" /db_xref="EnsemblGenomes-Gn:BSU23470" /db_xref="EnsemblGenomes-Tr:CAB14279" /db_xref="GOA:P10727" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR003658" /db_xref="InterPro:IPR014237" /db_xref="InterPro:IPR036513" /db_xref="PDB:1AUZ" /db_xref="PDB:1BUZ" /db_xref="SubtiList:BG10296" /db_xref="UniProtKB/Swiss-Prot:P10727" /translation="MSLGIDMNVKESVLCIRLTGELDHHTAETLKQKVTQSLEKDDIR HIVLNLEDLSFMDSSGLGVILGRYKQIKQIGGEMVVCAISPAVKRLFDMSGLFKIIRF EQSEQQALLTLGVAS*" /label="spoIIAA CDS" gene complement(2140852..2141205) /gene="spoIIAA" /locus_tag="BSU_23470" /old_locus_tag="BSU23470" /label="spoIIAA gene" promotor_-10 complement(2141230..2141248) /Source="Nicolas_upshift_promotors" /id="U1834" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=445 /SigmaFactorBS="attatgccgaatgaccactagttttgtcacggtGAAGGAATT cattccgtcgaAATCGAAACACTCATTATCcgatcatatcaaggaggaatgagcatga g" /listShort="spoIIAA, spoIIAB, sigF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2141241) /Source="Nicolas_upshifts" /id="U1834" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=445 /SigmaFactorBS="attatgccgaatgaccactagttttgtcacggtGAAGGAATT cattccgtcgaAATCGAAACACTCATTATCcgatcatatcaaggaggaatgagcatga g" /listShort="spoIIAA, spoIIAB, sigF" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2141243..2141300) /Source="Nicolas_S_feature" /locus_tag="new_2445036_2445093_c" /HighExp="S4, S3, S7, S5, S8, S6, T5.0H, BT, LoTm, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.859" /TUlongSig="NA" /TUlongPSig="NA" /label="S889" promotor_-35 complement(2141260..2141268) /Source="Nicolas_upshift_promotors" /id="U1834" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=445 /SigmaFactorBS="attatgccgaatgaccactagttttgtcacggtGAAGGAATT cattccgtcgaAATCGAAACACTCATTATCcgatcatatcaaggaggaatgagcatga g" /listShort="spoIIAA, spoIIAB, sigF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2141301..2142470) /gene="dacF" /locus_tag="BSU_23480" /old_locus_tag="BSU23480" /EC_number="3.4.16.4" /function="16.8: Protect" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:8021191, 8936302, 9864321, 19189487" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8021191, 8936302, 9864321, 19189487; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-alanyl-D-alanine carboxypeptidase (penicilin binding protein)" /protein_id="NP_390229.1" /db_xref="EnsemblGenomes-Gn:BSU23480" /db_xref="EnsemblGenomes-Tr:CAB14280" /db_xref="GOA:P38422" /db_xref="InterPro:IPR001967" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR012907" /db_xref="InterPro:IPR015956" /db_xref="InterPro:IPR018044" /db_xref="InterPro:IPR037167" /db_xref="SubtiList:BG10295" /db_xref="UniProtKB/Swiss-Prot:P38422" /translation="MKRLLSTLLIGIMLLTFAPSAFAKQDGKRTSELAHEAKSAVLIE RDTGKVLYNKNSNERLAPASMTKIMTMLLIMEALDKGKIKMSDKVRTSEHAASMGGSQ IFLEPGEEMTVKEMLKGIAIASGNDASVAMAEFISGSEEEFVKKMNKKAKELGLKNTS FKNPTGLTEEGHYSSAYDMAIMAKELLKYESITKFTGTYEDYLRENTDKKFWLVNTNR LIKFYPGVDGVKTGYTGEAKYCLTASAKKGNMRAIAVVFGASTPKERNAQVTKMLDFA FSQYETHPLYKRNQTVAKVKVKKGKQKFIELTTSEPISILTKKGEDMNDVKKEIKMKD NISAPIQKGQELGTLVLKKDGEVLAESPVAAKEDMKKAGFITFLKRTMGDWTKFK*" /label="dacF CDS" gene complement(2141301..2142470) /gene="dacF" /locus_tag="BSU_23480" /old_locus_tag="BSU23480" /label="dacF gene" promotor_-10 complement(2142499..2142510) /Source="Nicolas_upshift_promotors" /id="U1835" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.85914085914086" /psig="0.85914085914086" /xcortree=1155 /SigmaFactorBS="tgtctttttttatgcccaaaattcgaaacattttccatcagt ggCGTATAAaaccatcacgcttGGAAAAAATAAAaaggattatgaaatggagggcttt t" /listShort="dacF, S889, spoIIAA, spoIIAB, sigF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2142514) /Source="Nicolas_upshifts" /id="U1835" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.85914085914086" /psig="0.85914085914086" /xcortree=1155 /SigmaFactorBS="tgtctttttttatgcccaaaattcgaaacattttccatcagt ggCGTATAAaaccatcacgcttGGAAAAAATAAAaaggattatgaaatggagggcttt t" /listShort="dacF, S889, spoIIAA, spoIIAB, sigF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2142524..2142530) /Source="Nicolas_upshift_promotors" /id="U1835" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.85914085914086" /psig="0.85914085914086" /xcortree=1155 /SigmaFactorBS="tgtctttttttatgcccaaaattcgaaacattttccatcagt ggCGTATAAaaccatcacgcttGGAAAAAATAAAaaggattatgaaatggagggcttt t" /listShort="dacF, S889, spoIIAA, spoIIAB, sigF" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2142616) /Source="Nicolas_upshifts" /id="D1226" /incds=0 /nref=243 /ntot=267 /MaxReadThrough="0.87114" /MaxDrop="7.5376" /score="26.8559416" /energy="-16.7" /TU="NA" /idTUdmin="U1836" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2142625..2143440) /gene="pupG" /locus_tag="BSU_23490" /old_locus_tag="BSU23490" /EC_number="2.4.2.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10537218, 15530033, 21279421, 21543875" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10537218, 15530033, 21279421, 21543875; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="purine nucleoside phosphorylase" /protein_id="NP_390230.1" /db_xref="EnsemblGenomes-Gn:BSU23490" /db_xref="EnsemblGenomes-Tr:CAB14281" /db_xref="GOA:P46354" /db_xref="InterPro:IPR000845" /db_xref="InterPro:IPR011268" /db_xref="InterPro:IPR011270" /db_xref="InterPro:IPR018099" /db_xref="InterPro:IPR035994" /db_xref="SubtiList:BG11330" /db_xref="UniProtKB/Swiss-Prot:P46354" /translation="MKDRIERAAAFIKQNLPESPKIGLILGSGLGILADEIENPVKLK YEDIPEFPVSTVEGHAGQLVLGTLEGVSVIAMQGRFHFYEGYSMEKVTFPVRVMKALG VEALIVTNAAGGVNTEFRAGDLMIITDHINFMGTNPLIGPNEADFGARFPDMSSAYDK DLSSLAEKIAKDLNIPIQKGVYTAVTGPSYETPAEVRFLRTMGSDAVGMSTVPEVIVA NHAGMRVLGISCISNAAAGILDQPLSHDEVMEVTEKVKAGFLKLVKAIVAQYE*" /label="pupG CDS" gene complement(2142625..2143440) /gene="pupG" /locus_tag="BSU_23490" /old_locus_tag="BSU23490" /label="pupG gene" CDS complement(2143453..2144637) /gene="deoB" /locus_tag="BSU_23500" /old_locus_tag="BSU23500" /EC_number="5.4.2.7" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10537218, 26211718" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10537218, 26211718; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="1,5-phosphopentomutase" /protein_id="NP_390231.2" /db_xref="EnsemblGenomes-Gn:BSU23500" /db_xref="EnsemblGenomes-Tr:CAB14282" /db_xref="GOA:P46353" /db_xref="InterPro:IPR006124" /db_xref="InterPro:IPR010045" /db_xref="InterPro:IPR017849" /db_xref="InterPro:IPR017850" /db_xref="InterPro:IPR024052" /db_xref="SubtiList:BG11331" /db_xref="UniProtKB/Swiss-Prot:P46353" /translation="MPAYKYNRVFLIVMDSVGIGEAPDAADFNDEGAHTLGHIAEHMN GLHMPNMAKLGLGLIEDIKGVEKTEHPLAYYGKMQEASNGKDTMTGHWEIMGLYIDKP FKVFPEGFPDELLQELEKRSGRKIIGNKPASGTAILDELGQEHMETGALIVYTSADSV LQIAAHEEVVPLEELYRICETARELTLDPKYMVGRIIARPFVGEPGQFKRTPNRHDYA LKPFDRTVMNELKDCGLDVISIGKISDIYDGEGITSSRRTVSNMDGMDKVIDTLGEDF TGLSFANLVDFDALFGHRRDPEGYGRALEEFDARLPEVFEKMREDDLLIITADHGNDP IHHGTDHTREYVPILAYSKKHKKAQMLPLADTFADIGATIADNFQTNKPKYGKSFLSL LQ*" /label="deoB CDS" gene complement(2143453..2144637) /gene="deoB" /locus_tag="BSU_23500" /old_locus_tag="BSU23500" /label="deoB gene" promotor_-10 complement(2144686..2144705) /Source="Nicolas_upshift_promotors" /id="U1836" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=1806 /SigmaFactorBS="acagaaaatattgaagtttctcattatttccaaataCATTGT CAacgggaatgaaaacgGTTTATACTTGAGTTGTCAGacctcttagcgatacaataga c" /listShort="drm, pupG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2144704) /Source="Nicolas_upshifts" /id="U1836" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=1806 /SigmaFactorBS="acagaaaatattgaagtttctcattatttccaaataCATTGT CAacgggaatgaaaacgGTTTATACTTGAGTTGTCAGacctcttagcgatacaataga c" /listShort="drm, pupG" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2144706..2144797) /Source="Nicolas_S_feature" /locus_tag="new_2448499_2448590_c" /HighExp="S3, S4, M0t90, G180, S7, S8, Glucon, G135, S5, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB, SigEF, SigA" /TUshortPSig="1, 1, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S890" promotor_-35 complement(2144721..2144728) /Source="Nicolas_upshift_promotors" /id="U1836" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=1806 /SigmaFactorBS="acagaaaatattgaagtttctcattatttccaaataCATTGT CAacgggaatgaaaacgGTTTATACTTGAGTTGTCAGacctcttagcgatacaataga c" /listShort="drm, pupG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2144798..2145688) /gene="ripX" /locus_tag="BSU_23510" /old_locus_tag="BSU23510" /function="16.9: Replicate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10498718, 11134515, 11208805, 16553881, 16597952, 21239579, 23305333" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10498718, 11134515, 11208805, 16553881, 16597952, 21239579, 23305333; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="site-specific tyrosine recombinase for chromosome partitioning" /protein_id="NP_390232.2" /db_xref="EnsemblGenomes-Gn:BSU23510" /db_xref="EnsemblGenomes-Tr:CAB14283" /db_xref="GOA:P46352" /db_xref="InterPro:IPR002104" /db_xref="InterPro:IPR004107" /db_xref="InterPro:IPR010998" /db_xref="InterPro:IPR011010" /db_xref="InterPro:IPR011932" /db_xref="InterPro:IPR013762" /db_xref="InterPro:IPR023009" /db_xref="SubtiList:BG11332" /db_xref="UniProtKB/Swiss-Prot:P46352" /translation="MKDQIKDFIHYVMVERGLSQNTIVSYERDLKSYSLYLTETLHVT DWNHVTRIHIIQYLKHLKDSGKSGKTSARHLASIRSFHQFLLREKVTDKDPSVHIETQ KTERALPKVLALNEVERLLDTPKLTSPFGYRDKAMLELLYATGIRVSEMIELKTADVH LSMGFIRCFGKGRKERIVPIGEAAASAIEEYMTKARGKLLKNNVSDALFLNHHGKQIS RQGFWKNLKKIALEAGIKKELTPHTLRHSFATHLLENGADLRAVQEMLGHADISTTQI YTHVTKTRLKDVYKQFHPRA*" /label="ripX CDS" gene complement(2144798..2145688) /gene="ripX" /locus_tag="BSU_23510" /old_locus_tag="BSU23510" /label="ripX gene" CDS complement(2145696..2145923) /gene="yqzK" /locus_tag="BSU_23519" /old_locus_tag="BSU23519" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097760.1" /db_xref="EnsemblGenomes-Gn:BSU23519" /db_xref="EnsemblGenomes-Tr:CAX52660" /db_xref="GOA:C0H451" /db_xref="InterPro:IPR025321" /db_xref="UniProtKB/Swiss-Prot:C0H451" /translation="MGRFLKTAVDALKVFILFTGFTALFYYAMIWVNQEYENYHRYDK PEGSAVKVVEMDQDEKGGWFDRLIFFYQNGE*" /label="yqzK CDS" gene complement(2145696..2145923) /gene="yqzK" /locus_tag="BSU_23519" /old_locus_tag="BSU23519" /label="yqzK gene" promotor_-10 complement(2145826..2145845) /Source="Nicolas_upshift_promotors" /id="U1837" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.835164835164835" /psig=1 /xcortree=3146 /SigmaFactorBS="cgatgcattgaaagttttcatcctgtttaccGGTTTTACcgc tttgttctatTATGCTATGATATGGGTGAAtcaagagtatgaaaactatcatcggtat g" /listShort="ripX, S890, drm, pupG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2145837) /Source="Nicolas_upshifts" /id="U1837" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.835164835164835" /psig=1 /xcortree=3146 /SigmaFactorBS="cgatgcattgaaagttttcatcctgtttaccGGTTTTACcgc tttgttctatTATGCTATGATATGGGTGAAtcaagagtatgaaaactatcatcggtat g" /listShort="ripX, S890, drm, pupG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2145859..2145866) /Source="Nicolas_upshift_promotors" /id="U1837" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.835164835164835" /psig=1 /xcortree=3146 /SigmaFactorBS="cgatgcattgaaagttttcatcctgtttaccGGTTTTACcgc tttgttctatTATGCTATGATATGGGTGAAtcaagagtatgaaaactatcatcggtat g" /listShort="ripX, S890, drm, pupG" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2145916) /Source="Nicolas_upshifts" /id="U1838" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=180 /SigmaFactorBS="atttggcatatGGTTTATataactggaaccataGGGAAAGGA TCGATTAGGAcatgggaagattcctgaaaacagctgtcgatgcattgaaagttttcat c" /listShort="yqzK, ripX, S890, drm, pupG" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2145925..2145943) /Source="Nicolas_upshift_promotors" /id="U1838" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=180 /SigmaFactorBS="atttggcatatGGTTTATataactggaaccataGGGAAAGGA TCGATTAGGAcatgggaagattcctgaaaacagctgtcgatgcattgaaagttttcat c" /listShort="yqzK, ripX, S890, drm, pupG" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2145953..2145971) /Source="Nicolas_upshift_promotors" /id="U1839" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1165 /SigmaFactorBS="ttctcatggggaaagggttttttgctgtttctaTGTATAaaa cctttctgatttgGCATATGGTTTATATAACTggaaccatagggaaaggatcgattag g" /listShort="yqzK, ripX, S890, drm, pupG" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2145959..2145965) /Source="Nicolas_upshift_promotors" /id="U1838" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=180 /SigmaFactorBS="atttggcatatGGTTTATataactggaaccataGGGAAAGGA TCGATTAGGAcatgggaagattcctgaaaacagctgtcgatgcattgaaagttttcat c" /listShort="yqzK, ripX, S890, drm, pupG" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2145966) /Source="Nicolas_upshifts" /id="U1839" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1165 /SigmaFactorBS="ttctcatggggaaagggttttttgctgtttctaTGTATAaaa cctttctgatttgGCATATGGTTTATATAACTggaaccatagggaaaggatcgattag g" /listShort="yqzK, ripX, S890, drm, pupG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2145988..2145993) /Source="Nicolas_upshift_promotors" /id="U1839" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1165 /SigmaFactorBS="ttctcatggggaaagggttttttgctgtttctaTGTATAaaa cctttctgatttgGCATATGGTTTATATAACTggaaccatagggaaaggatcgattag g" /listShort="yqzK, ripX, S890, drm, pupG" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2146048) /Source="Nicolas_upshifts" /id="D1227" /incds=0 /nref=159 /ntot=251 /MaxReadThrough="4.06128" /MaxDrop="5.73495" /score="5.40881961" /energy="-8.1" /TU="U1840" /idTUdmin="U1841" /TUdmin=506 /isTUend="FALSE" /label="downshifts" CDS complement(2146048..2146497) /gene="fur" /locus_tag="BSU_23520" /old_locus_tag="BSU23520" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12029044, 12374814, 14563870, 15802251, 16672620, 25160631, 25209494" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12029044, 12374814, 14563870, 15802251, 16672620, 25160631, 25209494; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator for iron transport andmetabolism" /protein_id="NP_390233.2" /db_xref="EnsemblGenomes-Gn:BSU23520" /db_xref="EnsemblGenomes-Tr:CAB14284" /db_xref="GOA:P54574" /db_xref="InterPro:IPR002481" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11766" /db_xref="UniProtKB/Swiss-Prot:P54574" /translation="MENRIDRIKKQLHSSSYKLTPQREATVRVLLENEEDHLSAEDVY LLVKEKSPEIGLATVYRTLELLTELKVVDKINFGDGVSRYDLRKEGAAHFHHHLVCME CGAVDEIEEDLLEDVEEIIERDWKFKIKDHRLTFHGICHRCNGKETE*" /label="fur CDS" gene complement(2146048..2146497) /gene="fur" /locus_tag="BSU_23520" /old_locus_tag="BSU23520" /label="fur gene" promotor_-10 complement(2146521..2146540) /Source="Nicolas_upshift_promotors" /id="U1840" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.893106893106893" /psig=1 /xcortree=2743 /SigmaFactorBS="accattttatttatcagtttataataattatAGTTGgaactc tgcgcgtatTTTGTTATAATGAGTCATGGaatgcggcgtaggagggaaagacatggaa a" /listShort="fur, yqzK, ripX, S890" /listLong="drm, pupG" /label="promotor_-10" upshifts complement(2146531) /Source="Nicolas_upshifts" /id="U1840" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.893106893106893" /psig=1 /xcortree=2743 /SigmaFactorBS="accattttatttatcagtttataataattatAGTTGgaactc tgcgcgtatTTTGTTATAATGAGTCATGGaatgcggcgtaggagggaaagacatggaa a" /listShort="fur, yqzK, ripX, S890" /listLong="drm, pupG" /label="upshifts" S_feature complement(2146533..2146609) /Source="Nicolas_S_feature" /locus_tag="new_2450326_2450402_c" /HighExp="S3, S4, S5, BT, LoTm, M9-stat, T5.0H, T3.30H, T4.0H, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S891" promotor_-35 complement(2146556..2146560) /Source="Nicolas_upshift_promotors" /id="U1840" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.893106893106893" /psig=1 /xcortree=2743 /SigmaFactorBS="accattttatttatcagtttataataattatAGTTGgaactc tgcgcgtatTTTGTTATAATGAGTCATGGaatgcggcgtaggagggaaagacatggaa a" /listShort="fur, yqzK, ripX, S890" /listLong="drm, pupG" /label="promotor_-35" CDS complement(2146610..2147254) /gene="spoIIM" /locus_tag="BSU_23530" /old_locus_tag="BSU23530" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 17376078, 17824930, 20382772, 23859254" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 17376078, 17824930, 20382772, 23859254; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="autolysin component for dissolution of the septal cell wall (stage II sporulation)" /protein_id="NP_390234.1" /db_xref="EnsemblGenomes-Gn:BSU23530" /db_xref="EnsemblGenomes-Tr:CAB14285" /db_xref="GOA:P37873" /db_xref="InterPro:IPR002798" /db_xref="InterPro:IPR014196" /db_xref="SubtiList:BG10768" /db_xref="UniProtKB/Swiss-Prot:P37873" /translation="MRKISYKDMFLRHVKDHLSLYIFVSVLFFMGVIFGAIIVNSMTI SQKEDLYYYLSQFFGQLSDGKQASSADMFGQSIFHNAKYLGLMWILGISVIGMPIIFI MIFLKGIVVGFTVGFLVNQMGVSGFFLSFVSVLPQNVLLIPAYLIMGTCAIAFSLKLI RQLFVKRSLHDAPIQWFGRYAFVLLVILFLALISSLFEAYLSPVLMEKLTSRLF*" /label="spoIIM CDS" gene complement(2146610..2147254) /gene="spoIIM" /locus_tag="BSU_23530" /old_locus_tag="BSU23530" /label="spoIIM gene" promotor_-10 complement(2147285..2147303) /Source="Nicolas_upshift_promotors" /id="U1841" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=995 /SigmaFactorBS="ccgcctagcattcatctctattgtttctttttgaaaaagGGC ATGtttttctgtttcttTCATACAATCTATTAAATCaaatcactagagcgggcgggag g" /listShort="spoIIM, S891" /listLong="fur" /label="promotor_-10" upshifts complement(2147302) /Source="Nicolas_upshifts" /id="U1841" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=995 /SigmaFactorBS="ccgcctagcattcatctctattgtttctttttgaaaaagGGC ATGtttttctgtttcttTCATACAATCTATTAAATCaaatcactagagcgggcgggag g" /listShort="spoIIM, S891" /listLong="fur" /label="upshifts" promotor_-35 complement(2147318..2147323) /Source="Nicolas_upshift_promotors" /id="U1841" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=995 /SigmaFactorBS="ccgcctagcattcatctctattgtttctttttgaaaaagGGC ATGtttttctgtttcttTCATACAATCTATTAAATCaaatcactagagcgggcgggag g" /listShort="spoIIM, S891" /listLong="fur" /label="promotor_-35" CDS complement(2147355..2147570) /gene="yqkK" /locus_tag="BSU_23540" /old_locus_tag="BSU23540" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390235.1" /db_xref="EnsemblGenomes-Gn:BSU23540" /db_xref="EnsemblGenomes-Tr:CAB14286" /db_xref="SubtiList:BG11765" /db_xref="UniProtKB/Swiss-Prot:P54573" /translation="MAKSQAKKKRGHRLRNGGRDVLLSRGSTPSFSTHGRMTKSKKEI LNKRKHKNPYDHTAVDDKDFFVPQKAA*" /label="yqkK CDS" gene complement(2147355..2147570) /gene="yqkK" /locus_tag="BSU_23540" /old_locus_tag="BSU23540" /label="yqkK gene" downshifts complement(2147435) /Source="Nicolas_upshifts" /id="D1228" /incds=1 /nref=17 /ntot=130 /MaxReadThrough="0.857610000000001" /MaxDrop="3.7055" /score="1.77181315" /energy="-9.8" /TU="NA" /idTUdmin="U1842" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2147670..2148989) /gene="mleA" /locus_tag="BSU_23550" /old_locus_tag="BSU23550" /EC_number="1.1.1.38" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16788182, 23136871" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16788182, 23136871; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="catabolic NAD-dependent malic enzyme (conversionof malate into pyruvate)" /protein_id="NP_390236.1" /db_xref="EnsemblGenomes-Gn:BSU23550" /db_xref="EnsemblGenomes-Tr:CAB14287" /db_xref="GOA:P54572" /db_xref="InterPro:IPR001891" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR006140" /db_xref="InterPro:IPR012301" /db_xref="InterPro:IPR012302" /db_xref="InterPro:IPR015884" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR037062" /db_xref="SubtiList:BG11764" /db_xref="UniProtKB/Swiss-Prot:P54572" /translation="MIAKHMIRTLMIETPSVPGNLGRVATAIGLLGGDIGEVETVKVG PNYTMRNITVQVENEEQLQEVIAAVQALGEGIRLHTVSDEVLSAHEGGKIQMKSKMPI RSLAELGRVYTPGVADVCRLIEKEPEKASIYTTISNSVAIVTDGTAILGLGNIGSVAG MPVMEGKAALFDQLAGISGIPILLDTSDPEEIIKTVKHISPGFSGILLEDIGSPHCFE IEDRLKEELNIPVMHDDQHGTAVVTLAAAISACRSAGVDLKEAKVGQIGLGAAGVAIC RMFMAYGVNAVYGTDKSESAMNRLEQYGGQAVSSIEELMETCDIVIATTGVPGLIKPA FVRSGQVILALSNPKPEIEPEAALQAGAAYAADGRSVNNVLGFPGIFRGALNAKSTEI NHDMLVAAAEAIAACTKQGDVVPQPLDSKVHHAVAAAVEHAALTAVK*" /label="mleA CDS" gene complement(2147670..2148989) /gene="mleA" /locus_tag="BSU_23550" /old_locus_tag="BSU23550" /label="mleA gene" downshifts complement(2147677) /Source="Nicolas_upshifts" /id="D1229" /incds=0 /nref=29 /ntot=84 /MaxReadThrough="3.50516" /MaxDrop="5.65279" /score="42.1653011" /energy="-15.2" /TU="U1842,U1843" /idTUdmin="U1842" /TUdmin="-243" /isTUend="FALSE" /label="downshifts" CDS complement(2149007..2150413) /gene="mleN" /locus_tag="BSU_23560" /old_locus_tag="BSU23560" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10903309, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10903309, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="malate-H+/Na+-lactate antiporter" /protein_id="NP_390237.1" /db_xref="EnsemblGenomes-Gn:BSU23560" /db_xref="EnsemblGenomes-Tr:CAB14288" /db_xref="GOA:P54571" /db_xref="InterPro:IPR004770" /db_xref="InterPro:IPR018461" /db_xref="SubtiList:BG11763" /db_xref="UniProtKB/Swiss-Prot:P54571" /translation="MKDVRLPTLFEIIIVLGVFLALVLSFTVFLDLPIQLALFVSWFI AMLLGIRLGYSYKDLQNAIVHGISNGLEAVLILVSVGALIGTWIAGGVVPTLIYYGLE FIHPSIFLLATLIICSIMSVATGTSWGTVGTAGIAMIAIGEGLGIPLPLVAGAILSGA YFGDKLSPLSDSTVLASSLSKVDVLAHVRAMLYLSIPAYVITAILFTVVGFMYGGKNI DLDKVEFLKSSLQNTFDIHIWMLIPAVLVIVLLAMKKPSMPVIVIGALLGAIWAVVFQ GMDIAHAIATAYNGFSIKTDVEFLNGLLNRGGIVGMLDSLVVIIFGLGFGGLLEKLGV LKVIVSTFEKKLTSAGNVTLSTLIVAFLANIFGCAMYVSLILTPKIMEDSYDRLHLDR RVLSRNSEVGGTLTSGMVPWSDNGIYMAGILGVSTFSYLPFMWLSFVAIGLAIIYGYT GKFIWYTKNNTVKAEKLG*" /label="mleN CDS" gene complement(2149007..2150413) /gene="mleN" /locus_tag="BSU_23560" /old_locus_tag="BSU23560" /label="mleN gene" promotor_-10 complement(2150461..2150480) /Source="Nicolas_upshift_promotors" /id="U1842" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.964035964035964" /psig="0.998001998001998" /xcortree=2714 /SigmaFactorBS="tcatctccgaatagtcggatgaataagcTGTTTACAacatag ggatgaggAAGTATAGTATACGTGTTGCactatatattgaaagcgttttagcttttac a" /listShort="mleN, mleA, yqkK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2150470) /Source="Nicolas_upshifts" /id="U1842" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.964035964035964" /psig="0.998001998001998" /xcortree=2714 /SigmaFactorBS="tcatctccgaatagtcggatgaataagcTGTTTACAacatag ggatgaggAAGTATAGTATACGTGTTGCactatatattgaaagcgttttagcttttac a" /listShort="mleN, mleA, yqkK" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2150472..2150553) /Source="Nicolas_S_feature" /locus_tag="new_2454265_2454346_c" /HighExp="S0, dia0, dia5, Lbexp, G150, Oxctl, G135, Mt0, Paraq, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.937" /TUlongSig="NA" /TUlongPSig="NA" /label="S892" promotor_-35 complement(2150495..2150502) /Source="Nicolas_upshift_promotors" /id="U1842" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.964035964035964" /psig="0.998001998001998" /xcortree=2714 /SigmaFactorBS="tcatctccgaatagtcggatgaataagcTGTTTACAacatag ggatgaggAAGTATAGTATACGTGTTGCactatatattgaaagcgttttagcttttac a" /listShort="mleN, mleA, yqkK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2150554..2151981) /gene="ansB" /locus_tag="BSU_23570" /old_locus_tag="BSU23570" /EC_number="4.3.1.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1711029" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1711029; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="L-aspartase (aspartate ammonia lyase)" /protein_id="NP_390238.2" /db_xref="EnsemblGenomes-Gn:BSU23570" /db_xref="EnsemblGenomes-Tr:CAB14289" /db_xref="GOA:P26899" /db_xref="InterPro:IPR000362" /db_xref="InterPro:IPR004708" /db_xref="InterPro:IPR008948" /db_xref="InterPro:IPR018951" /db_xref="InterPro:IPR020557" /db_xref="InterPro:IPR022761" /db_xref="InterPro:IPR024083" /db_xref="SubtiList:BG10301" /db_xref="UniProtKB/Swiss-Prot:P26899" /translation="MLNGQKEYRVEKDFLGEKQIEADVYYGIQTLRASENFPITGYKI HEEMINALAIVKKAAALANMDVKRLYEGIGQAIVQAADEILEGKWHDQFIVDPIQGGA GTSMNMNANEVIGNRALEIMGHKKGDYIHLSPNTHVNMSQSTNDVFPTAIHISTLKLL EKLLKTMEDMHSVFKQKAQEFDSVIKMGRTHLQDAVPIRLGQEFEAYSRVLERDIKRI KQSRQHLYEVNMGATAVGTGLNADPEYIKQVVKHLADISGLPLVGADHLVDATQNTDA YTEVSASLKVCMMNMSKIANDLRLMASGPRAGLAEISLPARQPGSSIMPGKVNPVMAE LINQIAFQVIGNDNTICLASEAGQLELNVMEPVLVFNLLQSISIMNNGFRSFTDNCLK GIEANEKRMKQYVEKSAGVITAVNPHLGYEAAARIAREAIMTGQSVRDLCLQHDVLTE EELDIILNPYEMTKPGIAGKELLEK*" /label="ansB CDS" gene complement(2150554..2151981) /gene="ansB" /locus_tag="BSU_23570" /old_locus_tag="BSU23570" /label="ansB gene" CDS complement(2152026..2153015) /gene="ansA" /locus_tag="BSU_23580" /old_locus_tag="BSU23580" /EC_number="3.5.1.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1711029, 11914346, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1711029, 11914346, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exported L-asparaginase" /protein_id="NP_390239.1" /db_xref="EnsemblGenomes-Gn:BSU23580" /db_xref="EnsemblGenomes-Tr:CAB14290" /db_xref="GOA:P26900" /db_xref="InterPro:IPR006033" /db_xref="InterPro:IPR006034" /db_xref="InterPro:IPR020827" /db_xref="InterPro:IPR027473" /db_xref="InterPro:IPR027474" /db_xref="InterPro:IPR027475" /db_xref="InterPro:IPR036152" /db_xref="InterPro:IPR037152" /db_xref="SubtiList:BG10300" /db_xref="UniProtKB/Swiss-Prot:P26900" /translation="MKKLLMLTTGGTIASVEGENGLAPGVKADELLSYVSKLDNDYTM ETQSLMNIDSTNMQPEYWVEIAEAVKENYDAYDGFVITHGTDTMAYTSAALSYMLQHA KKPIVITGSQIPITFQKTDAKKNITDAIRFACEGVGGVYVVFDGRVIQGTRAIKLRTK SYDAFESINYPYIAFINEDGIEYNKQVTEPENDTFTVDTSLCTDVCLLKLHPGLKPEM FDALKSMYKGIVIESYGSGGVPFEGRDILSKVNELIESGIVVVITTQCLEEGEDMSIY EVGRRVNQDLIIRSRNMNTEAIVPKLMWALGQSSDLPVVKRIMETPIADDVVL*" /label="ansA CDS" gene complement(2152026..2153015) /gene="ansA" /locus_tag="BSU_23580" /old_locus_tag="BSU23580" /label="ansA gene" S_feature complement(2153016..2153095) /Source="Nicolas_S_feature" /locus_tag="new_2456809_2456888_c" /HighExp="dia0, Lbexp, G150, Oxctl, dia5, LBGexp, Paraq, C30, G180, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.937" /TUlongSig="NA" /TUlongPSig="NA" /label="S893" promotor_-10 complement(2153077..2153096) /Source="Nicolas_upshift_promotors" /id="U1843" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.808191808191808" /psig=1 /xcortree=1807 /SigmaFactorBS="taggtattaggaagtgtacgcgaattgaataataatgTCTTG CGTattttattttccgtGTCTATAATTGCATTAAAAGtatgcgaaaagcgaatacctt c" /listShort="S893, ansA, ansB, S892, mleN, mleA, yqkK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2153095) /Source="Nicolas_upshifts" /id="U1843" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.808191808191808" /psig=1 /xcortree=1807 /SigmaFactorBS="taggtattaggaagtgtacgcgaattgaataataatgTCTTG CGTattttattttccgtGTCTATAATTGCATTAAAAGtatgcgaaaagcgaatacctt c" /listShort="S893, ansA, ansB, S892, mleN, mleA, yqkK" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2153097..2153417) /Source="Nicolas_S_feature" /locus_tag="new_2456890_2457210_c" /HighExp="LBGstat, S5, G135, S8, S6, LBGtran, G180, G150, LoTm, LBGexp" /AntisenseName="ansR" /AntisenseCor="0.23077291929287899" /AntisenseRegPval="-3.9" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.937" /TUlongSig="NA" /TUlongPSig="NA" /label="S894" promotor_-35 complement(2153111..2153118) /Source="Nicolas_upshift_promotors" /id="U1843" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.808191808191808" /psig=1 /xcortree=1807 /SigmaFactorBS="taggtattaggaagtgtacgcgaattgaataataatgTCTTG CGTattttattttccgtGTCTATAATTGCATTAAAAGtatgcgaaaagcgaatacctt c" /listShort="S893, ansA, ansB, S892, mleN, mleA, yqkK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2153136..2153143 /Source="Nicolas_upshift_promotors" /id="U1844" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.525474525474525" /psig="0.998001998001998" /xcortree=2183 /SigmaFactorBS="cggaaaataaaatacgcaagacattattattcaattcgCGTA CACTtcctaatacctaTATGATATAATCAGCTCAAGgtgaaaaaggagcggaagttca t" /listShort="ansR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2153156..2153175 /Source="Nicolas_upshift_promotors" /id="U1844" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.525474525474525" /psig="0.998001998001998" /xcortree=2183 /SigmaFactorBS="cggaaaataaaatacgcaagacattattattcaattcgCGTA CACTtcctaatacctaTATGATATAATCAGCTCAAGgtgaaaaaggagcggaagttca t" /listShort="ansR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2153158 /Source="Nicolas_upshifts" /id="U1844" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.525474525474525" /psig="0.998001998001998" /xcortree=2183 /SigmaFactorBS="cggaaaataaaatacgcaagacattattattcaattcgCGTA CACTtcctaatacctaTATGATATAATCAGCTCAAGgtgaaaaaggagcggaagttca t" /listShort="ansR" /GFF_Attribute="listLong" /label="upshifts" CDS 2153197..2153547 /gene="ansR" /locus_tag="BSU_23590" /old_locus_tag="BSU23590" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11914346" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11914346; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of ansAB (Xre family)" /protein_id="NP_390240.1" /db_xref="EnsemblGenomes-Gn:BSU23590" /db_xref="EnsemblGenomes-Tr:CAB14291" /db_xref="GOA:Q07683" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR027910" /db_xref="SubtiList:BG10299" /db_xref="UniProtKB/Swiss-Prot:Q07683" /translation="MNLDRLTELRKKKNWSLQYTADLLGIAKSTYAGYESGYRRPSLE ALAMLADLFDTTCDELLGREKQKQTAPQAIELATWSSLDFTISVDGQPLSEDEIIQLI TFIRTKRKVQEELS*" /label="ansR CDS" gene 2153197..2153547 /gene="ansR" /locus_tag="BSU_23590" /old_locus_tag="BSU23590" /label="ansR gene" S_feature complement(2153419..2153555) /Source="Nicolas_S_feature" /locus_tag="new_2457212_2457348_c" /HighExp="LBGstat, S8, S6, S7, S5, ferm, nit, LBGtran, BT, LPhT" /AntisenseName="ansR" /AntisenseCor="-0.22421651781702501" /AntisenseRegPval="-3.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.937" /TUlongSig="NA" /TUlongPSig="NA" /label="S895" downshifts complement(2153462) /Source="Nicolas_upshifts" /id="D1230" /incds=1 /nref=4 /ntot=116 /MaxReadThrough="3.90926" /MaxDrop="4.76642" /score="10.2434094" /energy="-23.6" /TU="U1847" /idTUdmin="U1845" /TUdmin=1451 /isTUend="FALSE" /label="downshifts" CDS complement(2153556..2154719) /gene="yqxK" /locus_tag="BSU_23600" /old_locus_tag="BSU23600" /function="16.11: Scavenge (Catabolism)" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative nucleotide binding protein" /protein_id="NP_390241.2" /db_xref="EnsemblGenomes-Gn:BSU23600" /db_xref="EnsemblGenomes-Tr:CAB14292" /db_xref="GOA:P38423" /db_xref="InterPro:IPR005287" /db_xref="InterPro:IPR010994" /db_xref="InterPro:IPR016195" /db_xref="SubtiList:BG11073" /db_xref="UniProtKB/Swiss-Prot:P38423" /translation="MKKIYADLHIHIGRTFTGRAVKITGAKTLTLDRILVEASEHKGI ELLGIIDCHSPEVILELEEGISSGKYRELDGGGIRYRSTTLLLGSELEIYDEACSGPI HVLVFMPTLADMKQFSNWLSARLKNIHLSSQRIYETGLNLQKKVQDMGGLFIPAHIFT PHKSLYGKGVKSSLTEVFDPSMIDAVELGLSCDTDMASHVSQLNPYPFLTNSDAHSLG KIGREYNELYVQSADFTEFALALKGQDDRKIIANYGLDPLLGKYYQTACEACGEPAVS GETACANCGKARFTKGVSDRLRELSDQLEVRVPRPRYVHQIPLQFVPGVGPKTLDKLK KAFGTEMAVLHEAAEEDLARVVPPKTAALIVKARSGKLELKAGGGGTYGKIKP*" /label="yqxK CDS" gene complement(2153556..2154719) /gene="yqxK" /locus_tag="BSU_23600" /old_locus_tag="BSU23600" /label="yqxK gene" CDS complement(2154716..2155273) /gene="nudF" /locus_tag="BSU_23610" /old_locus_tag="BSU23610" /EC_number="3.1.7.1" /EC_number="3.6.1.13" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10542272, 17693564, 21638333, 25212876; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isopentenyl pyrophosphate and dimethylallyl pyrophosphate diphosphatase (moonlighting ADP-ribose pyrophosphatase)" /protein_id="NP_390242.1" /db_xref="EnsemblGenomes-Gn:BSU23610" /db_xref="EnsemblGenomes-Tr:CAB14293" /db_xref="GOA:P54570" /db_xref="InterPro:IPR000086" /db_xref="InterPro:IPR015797" /db_xref="InterPro:IPR020084" /db_xref="InterPro:IPR020476" /db_xref="SubtiList:BG11762" /db_xref="UniProtKB/Swiss-Prot:P54570" /translation="MKSLEEKTIAKEQIFSGKVIDLYVEDVELPNGKASKREIVKHPG AVAVLAVTDEGKIIMVKQFRKPLERTIVEIPAGKLEKGEEPEYTALRELEEETGYTAK KLTKITAFYTSPGFADEIVHVFLAEELSVLEEKRELDEDEFVEVMEVTLEDALKLVES REVYDAKTAYAIQYLQLKEALQAQK*" /label="nudF CDS" gene complement(2154716..2155273) /gene="nudF" /locus_tag="BSU_23610" /old_locus_tag="BSU23610" /label="nudF gene" promotor_no_box complement(2155203..2155303) /Source="Nicolas_upshift_promotors" /id="U1845" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.688311688311688" /psig="0.01998001998002" /xcortree=1733 /SigmaFactorBS="tcatatagagacagaacgggagatgaagaaatgaaatcatta gaagaaaaaacaattgccaaagaacagattttttcgggtaaagtcattgatctttatg t" /listShort="nudF" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(2155243) /Source="Nicolas_upshifts" /id="U1845" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.688311688311688" /psig="0.01998001998002" /xcortree=1733 /SigmaFactorBS="tcatatagagacagaacgggagatgaagaaatgaaatcatta gaagaaaaaacaattgccaaagaacagattttttcgggtaaagtcattgatctttatg t" /listShort="nudF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2155287..2155292 /Source="Nicolas_upshift_promotors" /id="U1846" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1028 /SigmaFactorBS="ttttcttctaatgatttcatttcttcatctcccGTTCTGtct ctatatgatgccCCATACATTTTATCATACTagagcaaaagggggcttcttcgtgaaa g" /listShort="S896, yqkF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2155308..2155326 /Source="Nicolas_upshift_promotors" /id="U1846" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1028 /SigmaFactorBS="ttttcttctaatgatttcatttcttcatctcccGTTCTGtct ctatatgatgccCCATACATTTTATCATACTagagcaaaagggggcttcttcgtgaaa g" /listShort="S896, yqkF" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2155310..2155324) /Source="Nicolas_upshift_promotors" /id="U1847" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.404595404595405" /psig="0.937062937062937" /xcortree=2733 /SigmaFactorBS="tccgactaagacaacaccttttggcatgcggtgcactttcac gaagaagcccccttttgcTCTAgTATGATAAAATGTATggggcatcatatagagacag a" /listShort="nudF, yqxK, S895, S894, S893, ansA, ansB, S892" /listLong="mleN, mleA, yqkK" /label="promotor_-10" upshifts 2155314 /Source="Nicolas_upshifts" /id="U1846" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1028 /SigmaFactorBS="ttttcttctaatgatttcatttcttcatctcccGTTCTGtct ctatatgatgccCCATACATTTTATCATACTagagcaaaagggggcttcttcgtgaaa g" /listShort="S896, yqkF" /GFF_Attribute="listLong" /label="upshifts" S_feature 2155321..2155495 /Source="Nicolas_S_feature" /locus_tag="new_2459114_2459288" /HighExp="S4, S5, S3, S7, S6, LoTm, BT, T5.0H, G/S, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99962399999999996" /TUshortSig="SigEF" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S896" promotor_-35 complement(2155326..2155329) /Source="Nicolas_upshift_promotors" /id="U1847" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.404595404595405" /psig="0.937062937062937" /xcortree=2733 /SigmaFactorBS="tccgactaagacaacaccttttggcatgcggtgcactttcac gaagaagcccccttttgcTCTAgTATGATAAAATGTATggggcatcatatagagacag a" /listShort="nudF, yqxK, S895, S894, S893, ansA, ansB, S892" /listLong="mleN, mleA, yqkK" /label="promotor_-35" upshifts complement(2155329) /Source="Nicolas_upshifts" /id="U1847" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.404595404595405" /psig="0.937062937062937" /xcortree=2733 /SigmaFactorBS="tccgactaagacaacaccttttggcatgcggtgcactttcac gaagaagcccccttttgcTCTAgTATGATAAAATGTATggggcatcatatagagacag a" /listShort="nudF, yqxK, S895, S894, S893, ansA, ansB, S892" /listLong="mleN, mleA, yqkK" /label="upshifts" CDS 2155348..2155470 /gene="mciZ" /locus_tag="BSU_23616" /old_locus_tag="BSU23616" /function="15.1: Cell division" /experiment="publication(s) with functional evidences, PMID:18284588, 23237472, 25848052, 27752253" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18284588, 23237472, 25848052, 27752253; Product type f: factor" /codon_start=1 /transl_table=11 /product="cell division inhibitor" /protein_id="YP_009513976.1" /db_xref="EnsemblGenomes-Gn:BSU23616" /db_xref="EnsemblGenomes-Tr:CCQ48600" /db_xref="GOA:L8EBJ9" /db_xref="InterPro:IPR025177" /db_xref="PDB:2MRW" /db_xref="PDB:4U39" /db_xref="UniProtKB/TrEMBL:L8EBJ9" /translation="MKVHRMPKGVVLVGKAWEIRAKLKEYGRTFQYVKDWISKP*" /label="mciZ CDS" gene 2155348..2155470 /gene="mciZ" /locus_tag="BSU_23616" /old_locus_tag="BSU23616" /label="mciZ gene" promotor_-35 2155471..2155478 /Source="Nicolas_upshift_promotors" /id="U1848" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.717282717282717" /psig="0.998001998001998" /xcortree=1920 /SigmaFactorBS="tcaatatgtgaaagattggatctcaaagccataaAAGTTGAA actttagctccttTATATTACGGTCAATACAAAgcctaaaaaaggagtgtgcacatga g" /listShort="yqkF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2155492..2155511 /Source="Nicolas_upshift_promotors" /id="U1848" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.717282717282717" /psig="0.998001998001998" /xcortree=1920 /SigmaFactorBS="tcaatatgtgaaagattggatctcaaagccataaAAGTTGAA actttagctccttTATATTACGGTCAATACAAAgcctaaaaaaggagtgtgcacatga g" /listShort="yqkF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2155497 /Source="Nicolas_upshifts" /id="U1848" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.717282717282717" /psig="0.998001998001998" /xcortree=1920 /SigmaFactorBS="tcaatatgtgaaagattggatctcaaagccataaAAGTTGAA actttagctccttTATATTACGGTCAATACAAAgcctaaaaaaggagtgtgcacatga g" /listShort="yqkF" /GFF_Attribute="listLong" /label="upshifts" CDS 2155533..2156453 /gene="yqkF" /locus_tag="BSU_23620" /old_locus_tag="BSU23620" /EC_number="1.1.1.-" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 9643546, 15317791, 16242712, 24330391; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADPH-dependent aldo-keto reductase (acts on 4-hydroxy-2,3-trans-nonenal)" /protein_id="NP_390243.1" /db_xref="EnsemblGenomes-Gn:BSU23620" /db_xref="EnsemblGenomes-Tr:CAB14294" /db_xref="GOA:P54569" /db_xref="InterPro:IPR020471" /db_xref="InterPro:IPR023210" /db_xref="InterPro:IPR036812" /db_xref="SubtiList:BG11761" /db_xref="UniProtKB/Swiss-Prot:P54569" /translation="MRKRKLGTSDLDISEVGLGCMSLGTEKNKALSILDEAIELGINY LDTADLYDRGRNEEIVGDAIQNRRHDIILATKAGNRWDDGSEGWYWDPSKAYIKEAVK KSLTRLKTDYIDLYQLHGGTIEDNIDETIEAFEELKQEGVIRYYGISSIRPNVIKEYV KKSNIVSIMMQFSLFDRRPEEWLPLLEEHQISVVARGPVAKGLLTEKPLDQASESMKQ NGYLSYSFEELTNARKAMEEVAPDLSMTEKSLQYLLAQPAVASVITGASKIEQLRENI QAANARRLTEEEIKALQSHTKQDIYKAHRS*" /label="yqkF CDS" gene 2155533..2156453 /gene="yqkF" /locus_tag="BSU_23620" /old_locus_tag="BSU23620" /label="yqkF gene" downshifts 2156442 /Source="Nicolas_upshifts" /id="D1231" /incds=0 /nref=186 /ntot=248 /MaxReadThrough="1.49159" /MaxDrop="5.81013" /score="18.6018806" /energy="-14.8" /TU="NA" /idTUdmin="U1846" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2156485..2156709) /gene="yqkE" /locus_tag="BSU_23630" /old_locus_tag="BSU23630" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390244.1" /db_xref="EnsemblGenomes-Gn:BSU23630" /db_xref="EnsemblGenomes-Tr:CAB14295" /db_xref="InterPro:IPR024980" /db_xref="SubtiList:BG11760" /db_xref="UniProtKB/Swiss-Prot:P54568" /translation="MKKQKSIDKHQLKDGLQSDIKAKLMEMKSQLKEEDEKRQKREKA EQIRKKKEIEKNKSFEELLNESQMDWHQYK*" /label="yqkE CDS" gene complement(2156485..2156709) /gene="yqkE" /locus_tag="BSU_23630" /old_locus_tag="BSU23630" /label="yqkE gene" downshifts complement(2156542) /Source="Nicolas_upshifts" /id="D1232" /incds=0 /nref=19 /ntot=195 /MaxReadThrough="0.59953" /MaxDrop="5.9087" /score="15.8160537" /energy="-13" /TU="NA" /idTUdmin="U1849" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2156732..2156751) /Source="Nicolas_upshift_promotors" /id="U1849" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.718281718281718" /psig="0.996003996003996" /xcortree=2028 /SigmaFactorBS="gctgagaaagtgatcagaagagagtcTGCTTGTTcagtttat atgctcCGTGATAAACTGGCTTCAAAacaaaacatgggggaagtctgcatgaaaaaac a" /listShort="yqkE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2156739) /Source="Nicolas_upshifts" /id="U1849" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.718281718281718" /psig="0.996003996003996" /xcortree=2028 /SigmaFactorBS="gctgagaaagtgatcagaagagagtcTGCTTGTTcagtttat atgctcCGTGATAAACTGGCTTCAAAacaaaacatgggggaagtctgcatgaaaaaac a" /listShort="yqkE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2156766..2156773) /Source="Nicolas_upshift_promotors" /id="U1849" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.718281718281718" /psig="0.996003996003996" /xcortree=2028 /SigmaFactorBS="gctgagaaagtgatcagaagagagtcTGCTTGTTcagtttat atgctcCGTGATAAACTGGCTTCAAAacaaaacatgggggaagtctgcatgaaaaaac a" /listShort="yqkE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2156788..2156795 /Source="Nicolas_upshift_promotors" /id="U1850" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.7002997002997" /psig=1 /xcortree=3151 /SigmaFactorBS="tataaactgaacaagcagactctcttctgatCACTTTCTcag cgtagcagtgtTTAGGTATAATGATCTTAAAcacgaattgcctatatatttcgttgaa a" /listShort="yqkD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2156810..2156829 /Source="Nicolas_upshift_promotors" /id="U1850" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.7002997002997" /psig=1 /xcortree=3151 /SigmaFactorBS="tataaactgaacaagcagactctcttctgatCACTTTCTcag cgtagcagtgtTTAGGTATAATGATCTTAAAcacgaattgcctatatatttcgttgaa a" /listShort="yqkD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2156817 /Source="Nicolas_upshifts" /id="U1850" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.7002997002997" /psig=1 /xcortree=3151 /SigmaFactorBS="tataaactgaacaagcagactctcttctgatCACTTTCTcag cgtagcagtgtTTAGGTATAATGATCTTAAAcacgaattgcctatatatttcgttgaa a" /listShort="yqkD" /GFF_Attribute="listLong" /label="upshifts" CDS 2156871..2157788 /gene="yqkD" /locus_tag="BSU_23640" /old_locus_tag="BSU23640" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_390245.1" /db_xref="EnsemblGenomes-Gn:BSU23640" /db_xref="EnsemblGenomes-Tr:CAB14296" /db_xref="GOA:P54567" /db_xref="InterPro:IPR022742" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG11759" /db_xref="UniProtKB/Swiss-Prot:P54567" /translation="MKKILLAIGALVTAVIAIGIVFSHMILFIKKKTDEDIIKRETDN GHDVFESFEQMEKTAFVIPSAYGYDIKGYHVAPHDTPNTIIICHGVTMNVLNSLKYMH LFLDLGWNVLIYDHRRHGQSGGKTTSYGFYEKDDLNKVVSLLKNKTNHRGLIGIHGES MGAVTALLYAGAHCSDGADFYIADCPFACFDEQLAYRLRAEYRLPSWPLLPIADFFLK LRGGYRAREVSPLAVIDKIEKPVLFIHSKDDDYIPVSSTERLYEKKRGPKALYIAENG EHAMSYTKNRHTYRKTVQEFLDNMNDSTE*" /label="yqkD CDS" gene 2156871..2157788 /gene="yqkD" /locus_tag="BSU_23640" /old_locus_tag="BSU23640" /label="yqkD gene" downshifts 2157763 /Source="Nicolas_upshifts" /id="D1233" /incds=0 /nref=27 /ntot=171 /MaxReadThrough="2.02201" /MaxDrop="3.99393" /score="14.106821" /energy="-11.8" /TU="NA" /idTUdmin="U1850" /TUdmin=594 /isTUend="FALSE" /label="downshifts" CDS complement(2157828..2158067) /gene="yqkC" /locus_tag="BSU_23650" /old_locus_tag="BSU23650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390246.1" /db_xref="EnsemblGenomes-Gn:BSU23650" /db_xref="EnsemblGenomes-Tr:CAB14297" /db_xref="InterPro:IPR020157" /db_xref="SubtiList:BG11758" /db_xref="UniProtKB/Swiss-Prot:P54566" /translation="MEQKLKAMKNTAQNKTWVSFLNQNHPYTLLHWSIGGAESIKKDV WLLQDEMTFETQEFTTIDLAIEWIRENMDGITDVL*" /label="yqkC CDS" gene complement(2157828..2158067) /gene="yqkC" /locus_tag="BSU_23650" /old_locus_tag="BSU23650" /label="yqkC gene" downshifts complement(2157839) /Source="Nicolas_upshifts" /id="D1234" /incds=0 /nref=215 /ntot=269 /MaxReadThrough="3.31829" /MaxDrop="6.35785" /score="16.3526162" /energy="-11.2" /TU="NA" /idTUdmin="U1851" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2158080..2158403) /gene="yqkB" /locus_tag="BSU_23660" /old_locus_tag="BSU23660" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390247.1" /db_xref="EnsemblGenomes-Gn:BSU23660" /db_xref="EnsemblGenomes-Tr:CAB14298" /db_xref="InterPro:IPR000361" /db_xref="InterPro:IPR035903" /db_xref="SubtiList:BG11757" /db_xref="UniProtKB/Swiss-Prot:P54565" /translation="MNIHVTDAAKQALQQAFDANPGKKAQLRYDAEGCGCAVSGVPTI WLAEELTGQCEQLETNGIPLYIQSSQKVFFDDQMTIDYNEKAKTLALKSPAEMLSPRM SILVK*" /label="yqkB CDS" gene complement(2158080..2158403) /gene="yqkB" /locus_tag="BSU_23660" /old_locus_tag="BSU23660" /label="yqkB gene" promotor_-10 complement(2158146..2158165) /Source="Nicolas_upshift_promotors" /id="U1851" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig=1 /xcortree=2731 /SigmaFactorBS="tccaatcgtcgcaaaaagtgtTTTTTGACgatcaaatgacga TCGATTACAATGAAAAAGCCaaaacattggcgctgaaaagcccggctgaaatgctcag c" /listShort="yqkC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2158147) /Source="Nicolas_upshifts" /id="U1851" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig=1 /xcortree=2731 /SigmaFactorBS="tccaatcgtcgcaaaaagtgtTTTTTGACgatcaaatgacga TCGATTACAATGAAAAAGCCaaaacattggcgctgaaaagcccggctgaaatgctcag c" /listShort="yqkC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2158179..2158186) /Source="Nicolas_upshift_promotors" /id="U1851" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig=1 /xcortree=2731 /SigmaFactorBS="tccaatcgtcgcaaaaagtgtTTTTTGACgatcaaatgacga TCGATTACAATGAAAAAGCCaaaacattggcgctgaaaagcccggctgaaatgctcag c" /listShort="yqkC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2158400..2159431) /gene="yqkA" /locus_tag="BSU_23670" /old_locus_tag="BSU23670" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390248.1" /db_xref="EnsemblGenomes-Gn:BSU23670" /db_xref="EnsemblGenomes-Tr:CAB14299" /db_xref="GOA:P54564" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR007344" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG11756" /db_xref="UniProtKB/Swiss-Prot:P54564" /translation="MIEFLQHKEATIAREILAVQIPAYIKETEIIGFDGIPALQEKVK DIQASHERFAGYRKNGKLIGVISYEKNMHYLTICRLVVHPDGFRKGIGRALLQFVIDH NEDAEKIEVVTAENNTPAVSLYTQAGFQKAETVKAAQGLLLSVFHLYPKRKVEIILYN EKWAECFDEEKERLKLVFGPEIIAIHHIGSTSIPNMAAKPIIDMLIEVRSIEAVSQFD EQMKANGYTPKGENGIAGRRYFQKGGNKRTHHVHMYEQGNPAIERHLLFRDYLRAHPN IAKEYAVLKKQLAAQHPDSINQYIQGKDEWIKTAEENAKRWKKGRNNANGSIVCYNSE NDENGGFTL*" /label="yqkA CDS" gene complement(2158400..2159431) /gene="yqkA" /locus_tag="BSU_23670" /old_locus_tag="BSU23670" /label="yqkA gene" promotor_-10 complement(2158427..2158446) /Source="Nicolas_upshift_promotors" /id="U1852" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=2060 /SigmaFactorBS="atgcgaagcggtggaaaaaaggcagaaacaATGCGAATggca gtattgTATGCTACAATAGCGAAAATgatgaaaacgggggtttcaccttatgaacata c" /listShort="yqkB, yqkC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2158434) /Source="Nicolas_upshifts" /id="U1852" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=2060 /SigmaFactorBS="atgcgaagcggtggaaaaaaggcagaaacaATGCGAATggca gtattgTATGCTACAATAGCGAAAATgatgaaaacgggggtttcaccttatgaacata c" /listShort="yqkB, yqkC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2158457..2158464) /Source="Nicolas_upshift_promotors" /id="U1852" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.957042957042957" /psig=1 /xcortree=2060 /SigmaFactorBS="atgcgaagcggtggaaaaaaggcagaaacaATGCGAATggca gtattgTATGCTACAATAGCGAAAATgatgaaaacgggggtttcaccttatgaacata c" /listShort="yqkB, yqkC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2159424..2159768) /gene="yqjZ" /locus_tag="BSU_23680" /old_locus_tag="BSU23680" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16267290; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative degradation enzyme (oxygenase)" /protein_id="NP_390249.1" /db_xref="EnsemblGenomes-Gn:BSU23680" /db_xref="EnsemblGenomes-Tr:CAB14300" /db_xref="InterPro:IPR007138" /db_xref="InterPro:IPR011008" /db_xref="PDB:2GO8" /db_xref="SubtiList:BG11755" /db_xref="UniProtKB/Swiss-Prot:P54563" /translation="MMDFLSKTPEPPYYAVIFSSVKSENDTGYGETAERMVSLAADQP GFLGVESVREADGRGITVSYWDSMDAINHWRHHTEHQAAKEKGRSVWYESYAVRVAKV DRQRLFQENTND*" /label="yqjZ CDS" gene complement(2159424..2159768) /gene="yqjZ" /locus_tag="BSU_23680" /old_locus_tag="BSU23680" /label="yqjZ gene" CDS complement(2159778..2160248) /gene="yqjY" /locus_tag="BSU_23690" /old_locus_tag="BSU23690" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16267290; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_390250.1" /db_xref="EnsemblGenomes-Gn:BSU23690" /db_xref="EnsemblGenomes-Tr:CAB14301" /db_xref="GOA:P54562" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR017255" /db_xref="PDB:1MK4" /db_xref="SubtiList:BG11754" /db_xref="UniProtKB/Swiss-Prot:P54562" /translation="MDIRTITSSDYEMVTSVLNEWWGGRQLKEKLPRLFFEHFQDTSF ITSEHNSMTGFLIGFQSQSDPETAYIHFSGVHPDFRKMQIGKQLYDVFIETVKQRGCT RVKCVTSPVNKVSIAYHTKLGFDIEKGTKTVNGISVFANYDGPGQDRVLFVKNI*" /label="yqjY CDS" gene complement(2159778..2160248) /gene="yqjY" /locus_tag="BSU_23690" /old_locus_tag="BSU23690" /label="yqjY gene" S_feature complement(2160249..2160325) /Source="Nicolas_S_feature" /locus_tag="new_2464042_2464118_c" /HighExp="SMM, T-4.40H, MG 150, M9-tran, GM 90, T-3.40H, GM-0.2, M9-exp, GM 120, T-2.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigEF" /TUlongPSig="0.776" /label="S897" downshifts 2160249 /Source="Nicolas_upshifts" /id="D1235" /incds=0 /nref=8 /ntot=121 /MaxReadThrough="0.87367" /MaxDrop="3.61005" /score="-1.04904304" /energy="-6.5" /TU="NA" /idTUdmin="U1854" /TUdmin="-748" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2160300..2160319) /Source="Nicolas_upshift_promotors" /id="U1853" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig="0.999000999001" /xcortree=3045 /SigmaFactorBS="ttgttccctcggcagtctggaaacgtatgatacaggaaagaa ggCATTTACAattccagccaggcaAAATATAATTTTTATATTGTgagaaaaagagctg a" /listShort="S897, yqjY, yqjZ, yqkA, yqkB, yqkC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2160325) /Source="Nicolas_upshifts" /id="U1853" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig="0.999000999001" /xcortree=3045 /SigmaFactorBS="ttgttccctcggcagtctggaaacgtatgatacaggaaagaa ggCATTTACAattccagccaggcaAAATATAATTTTTATATTGTgagaaaaagagctg a" /listShort="S897, yqjY, yqjZ, yqkA, yqkB, yqkC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2160327..2160433) /Source="Nicolas_S_feature" /locus_tag="new_2464120_2464226_c" /HighExp="M40t90, S4, M40t45, S6, H2O2, S5, S3, S8, S7, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.776" /TUlongSig="NA" /TUlongPSig="NA" /label="S898" promotor_-35 complement(2160334..2160341) /Source="Nicolas_upshift_promotors" /id="U1853" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig="0.999000999001" /xcortree=3045 /SigmaFactorBS="ttgttccctcggcagtctggaaacgtatgatacaggaaagaa ggCATTTACAattccagccaggcaAAATATAATTTTTATATTGTgagaaaaagagctg a" /listShort="S897, yqjY, yqjZ, yqkA, yqkB, yqkC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2160434..2160772) /gene="yqjX" /locus_tag="BSU_23700" /old_locus_tag="BSU23700" /function="16.8: Protect" /function="16.5: Explore" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12137951, 16267290" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390251.1" /db_xref="EnsemblGenomes-Gn:BSU23700" /db_xref="EnsemblGenomes-Tr:CAB14302" /db_xref="GOA:P54561" /db_xref="InterPro:IPR014962" /db_xref="SubtiList:BG11753" /db_xref="UniProtKB/Swiss-Prot:P54561" /translation="MNDHLKRGNLLWEGSRMFLPEHKQSLLERKRLKQKLQKPILDPD KLEEMNQTLCAAMEFAQDITVSCFQDGEIVCCTGKICRYEEFEKAVWIKGDEDQLYKL KLDQVLDIVL*" /label="yqjX CDS" gene complement(2160434..2160772) /gene="yqjX" /locus_tag="BSU_23700" /old_locus_tag="BSU23700" /label="yqjX gene" CDS complement(2160769..2162007) /gene="polYB" /locus_tag="BSU_23710" /old_locus_tag="BSU23710" /EC_number="2.7.7.7" /function="16.5: Explore" /function="16.9: Replicate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12137951, 12644484, 15469515, 16045613, 16267290, 19924481, 24118570" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12137951, 12644484, 15469515, 16045613, 16267290, 19924481, 24118570; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="Y family DNA polymerase V bypassing lesions during replication" /protein_id="NP_390252.1" /db_xref="EnsemblGenomes-Gn:BSU23710" /db_xref="EnsemblGenomes-Tr:CAB14303" /db_xref="GOA:P54560" /db_xref="InterPro:IPR001126" /db_xref="InterPro:IPR017961" /db_xref="InterPro:IPR022880" /db_xref="InterPro:IPR036775" /db_xref="SubtiList:BG11752" /db_xref="UniProtKB/Swiss-Prot:P54560" /translation="MMKEKVIFLVDMQSFYASVEKAENPHLKNRPVIVSGDPEKRGGV VLAACPLAKQKGVVNASRLWEAQEKCPEAVVLRPRMQRYIDVSLQITAILEEYTDLVE PYSIDEQFMDITGSQKLFGTPMEIAKSIQGRIMREIGVYARVGIGPNKALAKIACDNF AKKNKNGIFTLTKENMKTEMWPLPVGSMFGVGSRMKHHLNRMGISTIGGLAAFPLDLL KKKWGINGHVLWMTANGIDYSPVSTSSLDGQKAIGHGMTLPRDYEHFDKEIKVVLLEL SEEVCRRSRNAGVMGQTVSVSCRGADFDWPTGFNRQVKLAEPTNSTQDVYEAVRRLFL TFWDGKPVRRLGVNLSQLSSDDIWQLNLFQDYAKKMSLGYVMDGIKNRFGDTAIIRAA SLTAAGQAFERAAKIGGHYK*" /label="polYB CDS" gene complement(2160769..2162007) /gene="polYB" /locus_tag="BSU_23710" /old_locus_tag="BSU23710" /label="polYB gene" misc_feature 2160931..2160932 /Source="Nicolas_upshift_promotors" /id="U1854" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95904095904096" /psig="0.005994005994006" /xcortree=20 /SigmaFactorBS="tcacatagcctaggctcattttctttgcataatcctgaaata aattgagCTgccatatgtcatcagatgagagctgagacagattgacaccgaggcggcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2160942 /Source="Nicolas_upshifts" /id="U1854" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.95904095904096" /psig="0.005994005994006" /xcortree=20 /SigmaFactorBS="tcacatagcctaggctcattttctttgcataatcctgaaata aattgagCTgccatatgtcatcagatgagagctgagacagattgacaccgaggcggcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2160997 /Source="Nicolas_upshifts" /id="D1236" /incds=1 /nref=2 /ntot=2 /MaxReadThrough="-0.14995" /MaxDrop="4.86715" /score="-1.04904304" /energy="-6.5" /TU="NA" /idTUdmin="U1854" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2162032..2162050) /Source="Nicolas_upshift_promotors" /id="U1855" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.776223776223776" /psig="0.776223776223776" /xcortree=763 /SigmaFactorBS="tattttctgtcagacaagaatcatttaccAGTATAaaacgaa catactttcGCATATAATGAAAAGCGAAcataagttctttttagaggtgtgtatgatg a" /listShort="polYB, yqjX, S898" /listLong="S897, yqjY, yqjZ, yqkA, yqkB, yqkC" /label="promotor_-10" upshifts complement(2162041) /Source="Nicolas_upshifts" /id="U1855" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.776223776223776" /psig="0.776223776223776" /xcortree=763 /SigmaFactorBS="tattttctgtcagacaagaatcatttaccAGTATAaaacgaa catactttcGCATATAATGAAAAGCGAAcataagttctttttagaggtgtgtatgatg a" /listShort="polYB, yqjX, S898" /listLong="S897, yqjY, yqjZ, yqkA, yqkB, yqkC" /label="upshifts" promotor_-35 complement(2162067..2162072) /Source="Nicolas_upshift_promotors" /id="U1855" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.776223776223776" /psig="0.776223776223776" /xcortree=763 /SigmaFactorBS="tattttctgtcagacaagaatcatttaccAGTATAaaacgaa catactttcGCATATAATGAAAAGCGAAcataagttctttttagaggtgtgtatgatg a" /listShort="polYB, yqjX, S898" /listLong="S897, yqjY, yqjZ, yqkA, yqkB, yqkC" /label="promotor_-35" promotor_-35 2162112..2162115 /Source="Nicolas_upshift_promotors" /id="U1856" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=2862 /SigmaFactorBS="tgattcttgtctgacagaaaatatgatccaaggGTTTgagag aagaaaaacATTTAGTAGAATAAAAGCGAagcataaggataggagagtcatgatggag a" /listShort="yqzH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2162130..2162149 /Source="Nicolas_upshift_promotors" /id="U1856" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=2862 /SigmaFactorBS="tgattcttgtctgacagaaaatatgatccaaggGTTTgagag aagaaaaacATTTAGTAGAATAAAAGCGAagcataaggataggagagtcatgatggag a" /listShort="yqzH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2162139 /Source="Nicolas_upshifts" /id="U1856" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=2862 /SigmaFactorBS="tgattcttgtctgacagaaaatatgatccaaggGTTTgagag aagaaaaacATTTAGTAGAATAAAAGCGAagcataaggataggagagtcatgatggag a" /listShort="yqzH" /GFF_Attribute="listLong" /label="upshifts" CDS 2162173..2162379 /gene="yqzH" /locus_tag="BSU_23720" /old_locus_tag="BSU23720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390253.1" /db_xref="EnsemblGenomes-Gn:BSU23720" /db_xref="EnsemblGenomes-Tr:CAB14304" /db_xref="InterPro:IPR025546" /db_xref="SubtiList:BG13774" /db_xref="UniProtKB/Swiss-Prot:O32014" /translation="MEKFVEKMLGQALRQYGRNVAIDPLSPYEKQSLKAALQERRNEE PDEDLHAHIEDIIYDYVTNQGLFS*" /label="yqzH CDS" gene 2162173..2162379 /gene="yqzH" /locus_tag="BSU_23720" /old_locus_tag="BSU23720" /label="yqzH gene" promotor_-35 2162862..2162865 /Source="Nicolas_upshift_promotors" /id="U1857" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.676323676323676" /psig="0.782217782217782" /xcortree=1401 /SigmaFactorBS="caataacgaaatattttgaacgatctATTGgagaaggaaatt ttTTCATATATGATAGAGAAAGatcatacatacaggagagaatataattcatgaagaa a" /listShort="yqjV, yqjU" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2162880..2162899 /Source="Nicolas_upshift_promotors" /id="U1857" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.676323676323676" /psig="0.782217782217782" /xcortree=1401 /SigmaFactorBS="caataacgaaatattttgaacgatctATTGgagaaggaaatt ttTTCATATATGATAGAGAAAGatcatacatacaggagagaatataattcatgaagaa a" /listShort="yqjV, yqjU" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2162896 /Source="Nicolas_upshifts" /id="U1857" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.676323676323676" /psig="0.782217782217782" /xcortree=1401 /SigmaFactorBS="caataacgaaatattttgaacgatctATTGgagaaggaaatt ttTTCATATATGATAGAGAAAGatcatacatacaggagagaatataattcatgaagaa a" /listShort="yqjV, yqjU" /GFF_Attribute="listLong" /label="upshifts" CDS 2162928..2164160 /gene="yqjV" /locus_tag="BSU_23730" /old_locus_tag="BSU23730" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12793527, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_390254.2" /db_xref="EnsemblGenomes-Gn:BSU23730" /db_xref="EnsemblGenomes-Tr:CAB14305" /db_xref="GOA:P54559" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11751" /db_xref="UniProtKB/Swiss-Prot:P54559" /translation="MKKWKDIHPISWTIIIGTIFGRMATSMSIPFLAIYLTAVQGASA SYAGLVIAASSSVGILASFYGGYISDKFGRKNMMLVSIFGWMLVFAGFAAASNLWVFF VVNALNGLCKSLFEPASKALLSDMTEEKTRLLVFNLRYAAINIGVVFGPVLGLYFGSS QSTTPFLVPAVIYGLYGIVLALQFKKHPSLSAPAQSRNMSVREAFMVTQKDYLFTIAL VGITLCTFGYSQFSSTFPQYMAQNPLIGNGTKLYGLMLTLNAIVVLATQFPIVHFAKR FSPLCSLMLGNVMVSISMAIFTVSHGVPSIVMIVITFTIGEVLLFSMMDLYVDQIAKP GLKGTYFGAIGFSQLGNVIGPWVGGICIDLFGAGRPIYIFSVLSGITLLGLPFLAFAY RQMKMETTKHRSRLEKPL*" /label="yqjV CDS" gene 2162928..2164160 /gene="yqjV" /locus_tag="BSU_23730" /old_locus_tag="BSU23730" /label="yqjV gene" CDS 2164007..2164369 /gene="yqjU" /locus_tag="BSU_23740" /old_locus_tag="BSU23740" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_390255.2" /db_xref="EnsemblGenomes-Gn:BSU23740" /db_xref="EnsemblGenomes-Tr:CAB14306" /db_xref="GOA:P54558" /db_xref="SubtiList:BG11750" /db_xref="UniProtKB/Swiss-Prot:P54558" /translation="MYRPVWRWPADLYFFCPERHYPARPAIFSVRLSANENGDHKTPF PSGKAALNKKRKRMNLSRKHEVKNMNIGDVMFQLFVFIIFAAVVFAAVTGFKYAKNRK AQLDRIEKKLNSLSEDHD*" /label="yqjU CDS" gene 2164007..2164369 /gene="yqjU" /locus_tag="BSU_23740" /old_locus_tag="BSU23740" /label="yqjU gene" S_feature complement(2164186..2164365) /Source="Nicolas_S_feature" /locus_tag="new_2467979_2468158_c" /HighExp="Sw, BC, C90, C30, M0t90, BI, Lbtran, Lbstat, M40t45, G135" /AntisenseName="yqjU" /AntisenseCor="-0.38632421151235602" /AntisenseRegPval="-10.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S899" downshifts complement(2164219) /Source="Nicolas_upshifts" /id="D1237" /incds=0 /nref=59 /ntot=226 /MaxReadThrough="1.66997" /MaxDrop="4.81479" /score="21.7095422" /energy="-11.4" /TU="NA" /idTUdmin="U1858" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2164366..2164752) /gene="yqjT" /locus_tag="BSU_23750" /old_locus_tag="BSU23750" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative lyase" /protein_id="NP_390256.1" /db_xref="EnsemblGenomes-Gn:BSU23750" /db_xref="EnsemblGenomes-Tr:CAB14307" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG11749" /db_xref="UniProtKB/Swiss-Prot:P54557" /translation="MHHIELYVSDLEASRRFWGWFLKELGYKEYQKWSSGISWKKDRF YLVIVQAKEPFLEPEYHRCRVGLNHLAFHAESKLQVDQMTEKLTAKGYRVLYRDRHPF AGGDGHYAVFCEDPDRIKVELVAPSC*" /label="yqjT CDS" gene complement(2164366..2164752) /gene="yqjT" /locus_tag="BSU_23750" /old_locus_tag="BSU23750" /label="yqjT gene" CDS complement(2164756..2165715) /gene="coaA" /locus_tag="BSU_23760" /old_locus_tag="BSU23760" /EC_number="2.7.1.33" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1328157, 24784177" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1328157, 24784177; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pantothenate kinase" /protein_id="NP_390257.2" /db_xref="EnsemblGenomes-Gn:BSU23760" /db_xref="EnsemblGenomes-Tr:CAB14308" /db_xref="GOA:P54556" /db_xref="InterPro:IPR004566" /db_xref="InterPro:IPR006083" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11748" /db_xref="UniProtKB/Swiss-Prot:P54556" /translation="MKNKELNLHTLYTQHNRESWSGFGGHLSIAVSEEEAKAVEGLND YLSVEEVETIYIPLVRLLHLHVKSAAERNKHVNVFLKHPHSAKIPFIIGIAGSVAVGK STTARILQKLLSRLPDRPKVSLITTDGFLFPTAELKKKNMMSRKGFPESYDVKALLEF LNDLKSGKDSVKAPVYSHLTYDREEGVFEVVEQADIVIIEGINVLQSPTLEDDRENPR IFVSDFFDFSIYVDAEESRIFTWYLERFRLLRETAFQNPDSYFHKFKDLSDQEADEMA ASIWESVNRPNLYENILPTKFRSDLILRKGDGHKVEEVLVRRV*" /label="coaA CDS" gene complement(2164756..2165715) /gene="coaA" /locus_tag="BSU_23760" /old_locus_tag="BSU23760" /label="coaA gene" S_feature complement(2165716..2165786) /Source="Nicolas_S_feature" /locus_tag="new_2469509_2469579_c" /HighExp="LBGtran, dia15, Diami, C90, H2O2, M0t45, G135, Lbtran, HiTm, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S900" CDS complement(2165787..2167133) /gene="dsdA" /locus_tag="BSU_23770" /old_locus_tag="BSU23770" /EC_number="4.3.1.18" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7592420; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="D-serine ammonia-lyase" /protein_id="NP_390258.2" /db_xref="EnsemblGenomes-Gn:BSU23770" /db_xref="EnsemblGenomes-Tr:CAB14309" /db_xref="GOA:P54555" /db_xref="InterPro:IPR000634" /db_xref="InterPro:IPR001926" /db_xref="InterPro:IPR011780" /db_xref="InterPro:IPR036052" /db_xref="SubtiList:BG11747" /db_xref="UniProtKB/Swiss-Prot:P54555" /translation="MSVHSEVLHALLKDPFIQKLIDAEPVFWANSGKKEGPLPRADEW ATEIAEAEKRMQRFAPYIAEVFPETKGAKGIIESPLFEVQHMKGKLEAAYQQPFPGRW LLKCDHELPISGSIKARGGIYEVLKYAENLALQEGMLQETDDYRILQEERFTGFFSRY SIAVGSTGNLGLSIGIIGAALGFRVTVHMSADAKQWKKDLLRQKGVTVMEYETDYSEA VNEGRRQAEQDPFCYFIDDEHSRQLFLGYAVAASRLKTQLDCMNIKPSLETPLFVYLP CGVGGGPGGVAFGLKLLYGDDVHVFFAEPTHSPCMLLGLYSGLHEKISVQDIGLDNQT AADGLAVGRPSGFVGKLIEPLLSGCYTVEDNTLYTLLHMLAVSEDKYLEPSALAGMFG PVQLFSTEEGRRYAQKYKMEHAVHVVWGTGGSMVPKDEMAAYNRIGADLLKKRNEK*" /label="dsdA CDS" gene complement(2165787..2167133) /gene="dsdA" /locus_tag="BSU_23770" /old_locus_tag="BSU23770" /label="dsdA gene" S_feature complement(2167134..2167208) /Source="Nicolas_S_feature" /locus_tag="new_2470927_2471001_c" /HighExp="C90, LBGtran, Diami, dia15, H2O2, dia5, G150, MG 15, GM-0.2, M40t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S901" CDS complement(2167209..2167988) /gene="yqjQ" /locus_tag="BSU_23780" /old_locus_tag="BSU23780" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metabolite dehydrogenase, NAD-binding" /protein_id="NP_390259.1" /db_xref="EnsemblGenomes-Gn:BSU23780" /db_xref="EnsemblGenomes-Tr:CAB14310" /db_xref="GOA:P54554" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11746" /db_xref="UniProtKB/Swiss-Prot:P54554" /translation="MKHIAGKRIWITGASGGLGERIAYLCAAEGAHVLLSARREDRLI EIKRKITEEWSGQCEIFPLDVGRLEDIARVRDQIGSIDVLINNAGFGIFETVLDSTLD DMKAMFDVNVFGLIACTKAVLPQMLEQKKGHIINIASQAGKIATPKSSLYSATKHAVL GYSNALRMELSGTGIYVTTVNPGPIQTDFFSIADKGGDYAKNVGRWMLDPDDVAAQIT AAIFTKKREINLPRLMNAGTKLYQLFPALVEKLAGRALMKK*" /label="yqjQ CDS" gene complement(2167209..2167988) /gene="yqjQ" /locus_tag="BSU_23780" /old_locus_tag="BSU23780" /label="yqjQ gene" CDS complement(2167994..2168953) /gene="yqjP" /locus_tag="BSU_23790" /old_locus_tag="BSU23790" /EC_number="3.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent hydrolase" /protein_id="NP_390260.1" /db_xref="EnsemblGenomes-Gn:BSU23790" /db_xref="EnsemblGenomes-Tr:CAB14311" /db_xref="GOA:P54553" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG11745" /db_xref="UniProtKB/Swiss-Prot:P54553" /translation="MTTEDVIAIRVPTPFAVGDVIVYLVKGDALTLIDAGPNTKEAAR ALQEQLAAVNVKLSDIEQVVLTHHHADHAGLLDVFSDEIEVIGHTFNEPYISQNQAFM DWQKRFFQKLLPELGVPFDTGKAEKLIRSAYAFSCTRSLTKSIREGMGIDGLEGWSVL EMPGHAESHIVLFHEKSGRMLGGDLLLANSSSNPILEAPKAGDVRSKPLVDYQRSLRR LSQLDPTIVFPGHGEPITSVQALIEKRFDKQRNRTEDVRRMLDEKPMTAFQVCQQLFP AVYEKELFLTMSETAGHLDVLEAEEAITSYWEGNTVYFKTMKR*" /label="yqjP CDS" gene complement(2167994..2168953) /gene="yqjP" /locus_tag="BSU_23790" /old_locus_tag="BSU23790" /label="yqjP gene" promotor_-10 complement(2168975..2168994) /Source="Nicolas_upshift_promotors" /id="U1858" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.597402597402597" /psig=1 /xcortree=2254 /SigmaFactorBS="caatagctttttcaaaaaggtttgttctcattctgcaaTAAT GACAcaagaccgagaaaaAGCTAAAATATGAATAATGAatgaagacaaggagcgaaag g" /listShort="yqjP, yqjQ, S901, dsdA, S900, coaA, yqjT, S899" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2168994) /Source="Nicolas_upshifts" /id="U1858" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.597402597402597" /psig=1 /xcortree=2254 /SigmaFactorBS="caatagctttttcaaaaaggtttgttctcattctgcaaTAAT GACAcaagaccgagaaaaAGCTAAAATATGAATAATGAatgaagacaaggagcgaaag g" /listShort="yqjP, yqjQ, S901, dsdA, S900, coaA, yqjT, S899" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2169009..2169016) /Source="Nicolas_upshift_promotors" /id="U1858" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.597402597402597" /psig=1 /xcortree=2254 /SigmaFactorBS="caatagctttttcaaaaaggtttgttctcattctgcaaTAAT GACAcaagaccgagaaaaAGCTAAAATATGAATAATGAatgaagacaaggagcgaaag g" /listShort="yqjP, yqjQ, S901, dsdA, S900, coaA, yqjT, S899" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2169050..2169057 /Source="Nicolas_upshift_promotors" /id="U1859" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.784215784215784" /psig="0.992007992007992" /xcortree=573 /SigmaFactorBS="tcattattgcagaatgagaacaaacctttttgaaaaagcTAT TGACAttagcttgtccgccaTTGCATAATGAACAACAAACtaaaacgagaaccattgg a" /listShort="S902, proI" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2169071..2169357 /Source="Nicolas_S_feature" /locus_tag="new_2472864_2473150" /HighExp="Diami, C90, BC, Paraq, G180, GM 15, Oxctl, S7, MG-0.2, MG t5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S902" upshifts 2169071 /Source="Nicolas_upshifts" /id="U1859" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.784215784215784" /psig="0.992007992007992" /xcortree=573 /SigmaFactorBS="tcattattgcagaatgagaacaaacctttttgaaaaagcTAT TGACAttagcttgtccgccaTTGCATAATGAACAACAAACtaaaacgagaaccattgg a" /listShort="S902, proI" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2169073..2169092 /Source="Nicolas_upshift_promotors" /id="U1859" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.784215784215784" /psig="0.992007992007992" /xcortree=573 /SigmaFactorBS="tcattattgcagaatgagaacaaacctttttgaaaaagcTAT TGACAttagcttgtccgccaTTGCATAATGAACAACAAACtaaaacgagaaccattgg a" /listShort="S902, proI" /GFF_Attribute="listLong" /label="promotor_-10" misc_RNA 2169087..2169332 /gene="pswI" /locus_tag="BSU_misc_RNA_91" /product="proline T-box riboswitch" /experiment="publication(s) with functional evidences, PMID:21233158" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21233158" /label="pswI RNA" gene 2169087..2169332 /gene="pswI" /locus_tag="BSU_misc_RNA_91" /label="pswI gene" CDS 2169358..2170194 /gene="proI" /locus_tag="BSU_23800" /old_locus_tag="BSU23800" /EC_number="1.5.1.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11418582, 21233158, 28752945, 28824574" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11418582, 21233158, 28752945, 28824574; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyrroline-5-carboxylate reductase (NADP-dependent, weak activity)" /protein_id="NP_390261.1" /db_xref="EnsemblGenomes-Gn:BSU23800" /db_xref="EnsemblGenomes-Tr:CAB14312" /db_xref="GOA:P54552" /db_xref="InterPro:IPR000304" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR028939" /db_xref="InterPro:IPR029036" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11744" /db_xref="UniProtKB/Swiss-Prot:P54552" /translation="MKKIGFVGAGSMAEAMINGILQSGITKPEHIYITNRSNDERLIE LKETYSVRPCRDKNEFFTHTDIIILAFKPKDAAESIDSIRPYIKDQLVISVLAGLTIE TIQHYFGRKLAVIRVMPNTSAAIRKSATGFSVSTEASKNDIIAAKALLETIGDATLVE ERHLDAVTAIAGSGPAYVYRYIEAMEKAAQKVGLDKETAKALILQTMAGATDMLLQSG KQPEKLRKEITSPGGTTEAGLRALQDSRFEEAIIHCIEETAKRSAEIKEQFAGAALER HS*" /label="proI CDS" gene 2169358..2170194 /gene="proI" /locus_tag="BSU_23800" /old_locus_tag="BSU23800" /label="proI gene" downshifts 2170192 /Source="Nicolas_upshifts" /id="D1238" /incds=0 /nref=29 /ntot=190 /MaxReadThrough="0.55696" /MaxDrop="3.78131" /score="36.2472665" /energy="-12" /TU="NA" /idTUdmin="U1859" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2170235..2171878) /gene="yqjN" /locus_tag="BSU_23810" /old_locus_tag="BSU23810" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-deacylase" /protein_id="NP_390262.2" /db_xref="EnsemblGenomes-Gn:BSU23810" /db_xref="EnsemblGenomes-Tr:CAB14313" /db_xref="GOA:P54551" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR012166" /db_xref="SubtiList:BG11743" /db_xref="UniProtKB/Swiss-Prot:P54551" /translation="MNWQTKDELLALLTSLVQYESITGSKGEVALAEYLYFILKDKPY FQKHPDDVTLHPMDDGRSFLTALVKKKNVKKTVLLLSHFDVVDIEDYGEFKHMACKPA ELLSSFLEKKELLPERVRRDAESGDWLFGRGTMDMKAGLCIQLSMLERAMNGHFEGNL LLITVPDEEVNSRGMIEAVPALKEMEKKHDITLTACLNAEPMFEKFPGDQQQYFYTGS IGKVLAGFFCKGIETHVGEPFSGLNANLMVSEINRLLELNADYCEKVDGEVTPPPVNL MQKDLKEAYSVQTPHTAVTLFNVLSMKRSASELHQMLLKTAEQAAEEIMSNVRKKTQD FQQFEPFQPIERDVTVLTFDELVSRAKKRAGISETERALNYAFANRGELGDRDFSTKI VSELASLCKEDAPLIVLFYSPPLYPAVSSKDDQLIRNTADQIKHYAAERYGIALREVQ YFPGLSDLSYLQLEKQEVDAYTSNMPLFNRGYSLPSGKNQALYVPVLNVGPAGKDPHK WTERLYMPYSFEVLPDLLSFTISALLKQSESAGQLLREK*" /label="yqjN CDS" gene complement(2170235..2171878) /gene="yqjN" /locus_tag="BSU_23810" /old_locus_tag="BSU23810" /label="yqjN gene" downshifts complement(2170247) /Source="Nicolas_upshifts" /id="D1239" /incds=0 /nref=1 /ntot=62 /MaxReadThrough="2.2598" /MaxDrop="2.55609" /score="14.9380989" /energy="-12" /TU="NA" /idTUdmin="U1861" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 2171896..2171902 /Source="Nicolas_upshift_promotors" /id="U1860" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.94105894105894" /psig="0.94105894105894" /xcortree=822 /SigmaFactorBS="cagcaattcgtccttcgtctgccaattcattgattccgcccc tcctaTGAATAAaaatgcttctataCTGAAAAATAAActgatttctcgtctattatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2171909 /Source="Nicolas_upshifts" /id="U1860" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.94105894105894" /psig="0.94105894105894" /xcortree=822 /SigmaFactorBS="cagcaattcgtccttcgtctgccaattcattgattccgcccc tcctaTGAATAAaaatgcttctataCTGAAAAATAAActgatttctcgtctattatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2171916..2171927 /Source="Nicolas_upshift_promotors" /id="U1860" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.94105894105894" /psig="0.94105894105894" /xcortree=822 /SigmaFactorBS="cagcaattcgtccttcgtctgccaattcattgattccgcccc tcctaTGAATAAaaatgcttctataCTGAAAAATAAActgatttctcgtctattatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature complement(2171934..2171953) /Source="Nicolas_upshift_promotors" /id="U1861" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.976023976023976" /psig="0.999000999001" /xcortree=397 /SigmaFactorBS="ctttcccgtcatataaactgctcaaatgaaccgcttttgtca aacaTTTCTGTATAATAGACGAGAaatcagtttatttttcagtatagaagcattttta t" /listShort="yqjN" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2171939) /Source="Nicolas_upshifts" /id="U1861" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.976023976023976" /psig="0.999000999001" /xcortree=397 /SigmaFactorBS="ctttcccgtcatataaactgctcaaatgaaccgcttttgtca aacaTTTCTGTATAATAGACGAGAaatcagtttatttttcagtatagaagcattttta t" /listShort="yqjN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2171985..2171992 /Source="Nicolas_upshift_promotors" /id="U1862" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.681318681318681" /psig="0.999000999001" /xcortree=1795 /SigmaFactorBS="cagaaatgtttgacaaaagcggttcatttgagcagttTATAT GACgggaaagaaatgaCTTGATATAATCAATCTCTAaaaaccttacgggaggcgaaag a" /listShort="yqjM, yqjL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2172006..2172025 /Source="Nicolas_upshift_promotors" /id="U1862" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.681318681318681" /psig="0.999000999001" /xcortree=1795 /SigmaFactorBS="cagaaatgtttgacaaaagcggttcatttgagcagttTATAT GACgggaaagaaatgaCTTGATATAATCAATCTCTAaaaaccttacgggaggcgaaag a" /listShort="yqjM, yqjL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2172008 /Source="Nicolas_upshifts" /id="U1862" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.681318681318681" /psig="0.999000999001" /xcortree=1795 /SigmaFactorBS="cagaaatgtttgacaaaagcggttcatttgagcagttTATAT GACgggaaagaaatgaCTTGATATAATCAATCTCTAaaaaccttacgggaggcgaaag a" /listShort="yqjM, yqjL" /GFF_Attribute="listLong" /label="upshifts" CDS 2172050..2173066 /gene="yqjM" /locus_tag="BSU_23820" /old_locus_tag="BSU23820" /EC_number="1.6.99.1" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12660247, 15249051, 15890652, 20011599, 20461254" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12660247, 15249051, 15890652, 20011599, 20461254; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADPH-dependent flavin oxidoreductase (acting oncinnamaldehyde-related compounds)" /protein_id="NP_390263.1" /db_xref="EnsemblGenomes-Gn:BSU23820" /db_xref="EnsemblGenomes-Tr:CAB14314" /db_xref="GOA:P54550" /db_xref="InterPro:IPR001155" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR023663" /db_xref="PDB:1Z41" /db_xref="PDB:1Z42" /db_xref="PDB:1Z44" /db_xref="PDB:1Z48" /db_xref="SubtiList:BG11742" /db_xref="UniProtKB/Swiss-Prot:P54550" /translation="MARKLFTPITIKDMTLKNRIVMSPMCMYSSHEKDGKLTPFHMAH YISRAIGQVGLIIVEASAVNPQGRITDQDLGIWSDEHIEGFAKLTEQVKEQGSKIGIQ LAHAGRKAELEGDIFAPSAIAFDEQSATPVEMSAEKVKETVQEFKQAAARAKEAGFDV IEIHAAHGYLIHEFLSPLSNHRTDEYGGSPENRYRFLREIIDEVKQVWDGPLFVRVSA SDYTDKGLDIADHIGFAKWMKEQGVDLIDCSSGALVHADINVFPGYQVSFAEKIREQA DMATGAVGMITDGSMAEEILQNGRADLIFIGRELLRDPFFARTAAKQLNTEIPAPVQY ERGW*" /label="yqjM CDS" gene 2172050..2173066 /gene="yqjM" /locus_tag="BSU_23820" /old_locus_tag="BSU23820" /label="yqjM gene" downshifts 2173053 /Source="Nicolas_upshifts" /id="D1240" /incds=0 /nref=42 /ntot=157 /MaxReadThrough="2.79686" /MaxDrop="5.04803" /score="39.119339" /energy="-12.8" /TU="U1862" /idTUdmin="U1862" /TUdmin="-770" /isTUend="FALSE" /label="downshifts" promotor_-35 2173115..2173124 /Source="Nicolas_upshift_promotors" /id="U1863" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1646 /SigmaFactorBS="atcctgtagaggatatctctttttttatttttagAGAAACGA TCggctaaggttctCCGTCTCCCTAGTAGAaccaattagaggagatgactccaatgaa a" /listShort="yqjL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2173137..2173152 /Source="Nicolas_upshift_promotors" /id="U1863" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1646 /SigmaFactorBS="atcctgtagaggatatctctttttttatttttagAGAAACGA TCggctaaggttctCCGTCTCCCTAGTAGAaccaattagaggagatgactccaatgaa a" /listShort="yqjL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2173141 /Source="Nicolas_upshifts" /id="U1863" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1646 /SigmaFactorBS="atcctgtagaggatatctctttttttatttttagAGAAACGA TCggctaaggttctCCGTCTCCCTAGTAGAaccaattagaggagatgactccaatgaa a" /listShort="yqjL" /GFF_Attribute="listLong" /label="upshifts" CDS 2173176..2173937 /gene="yqjL" /locus_tag="BSU_23830" /old_locus_tag="BSU23830" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15838020, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_390264.1" /db_xref="EnsemblGenomes-Gn:BSU23830" /db_xref="EnsemblGenomes-Tr:CAB14315" /db_xref="InterPro:IPR022742" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG11741" /db_xref="UniProtKB/Swiss-Prot:P54549" /translation="MKSAWMEKTYTIDGCAFHTQHRKGSSGVTIVFEAGYGTSSETWK PLMADIDDEFGIFTYDRAGIGKSGQSRAKRTADQQVKELESLLKAADVKPPYLAVSHS YGAVITGLWACKNKHDIIGMVLLDPALGDCASFTFIPEEMHKSHTRKMMLEGTHAEFS KSLQELKKRQVHLGNMPLLVLSSGERTEKFAAEQEWQNLHSSILSLSNQSGWIQAKNS SHNIHHDEPHIVHLAIYDVWCAACQQAAPLYQAVN*" /label="yqjL CDS" gene 2173176..2173937 /gene="yqjL" /locus_tag="BSU_23830" /old_locus_tag="BSU23830" /label="yqjL gene" downshifts 2173845 /Source="Nicolas_upshifts" /id="D1241" /incds=1 /nref=21 /ntot=204 /MaxReadThrough="3.34804" /MaxDrop="3.21955" /score="0.451826768" /energy="-11.2" /TU="U1863" /idTUdmin="U1862" /TUdmin=22 /isTUend="TRUE" /label="downshifts" downshifts 2173933 /Source="Nicolas_upshifts" /id="D1242" /incds=0 /nref=4 /ntot=33 /MaxReadThrough="1.34151" /MaxDrop="3.85711" /score="0.451826768" /energy="-11.2" /TU="NA" /idTUdmin="U1863" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2173965..2174165) /Source="Nicolas_S_feature" /locus_tag="new_2477758_2477958_c" /HighExp="B60, S5, Etha, S4, B36, BMM, Heat, S3, S2, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.21631400000000001" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S903" CDS complement(2173981..2174106) /gene="rpmGCc" /locus_tag="BSU_23836" /old_locus_tag="BSU23836" /function="10.2: Ribosomal proteins: synthesis and modification" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 27561249; Product type s: structure" /pseudo /codon_start=1 /transl_table=11 /product="ribosomal protein L33* pseudogene" /translation="CTETGDRNYITTKNKRTNPDRLELKKYSPRLKKYTLHRETK*" /label="rpmGCc CDS" gene complement(2173981..2174106) /gene="rpmGCc" /locus_tag="BSU_23836" /old_locus_tag="BSU23836" /pseudo /label="rpmGCc gene" downshifts complement(2174008) /Source="Nicolas_upshifts" /id="D1243" /incds=0 /nref=187 /ntot=264 /MaxReadThrough="3.91531" /MaxDrop="7.65732" /score="5.23287853" /energy="-8.8" /TU="U1864" /idTUdmin="U1865" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(2174099..2174131) /gene="rpmGCn" /locus_tag="BSU_23837" /old_locus_tag="BSU23837" /function="10.2: Ribosomal proteins: synthesis and modification" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 19648245, 27561249; Product type s: structure" /pseudo /codon_start=1 /transl_table=11 /product="ribosomal protein L33C pseudogene" /db_xref="PSEUDO:CCQ48601.1" /translation="MRVNVTLALH*" /label="rpmGCn CDS" gene complement(2174099..2174131) /gene="rpmGCn" /locus_tag="BSU_23837" /old_locus_tag="BSU23837" /pseudo /label="rpmGCn gene" promotor_-10 complement(2174159..2174178) /Source="Nicolas_upshift_promotors" /id="U1864" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.597402597402597" /psig=1 /xcortree=665 /SigmaFactorBS="cccgcgaggctgaaggcggagctcttaTTTGACAAtttgtga tgacgTTGTATAATAAAACGTAATCattacgttttataaggagatgttaattatgaga g" /listShort="S903" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2174165) /Source="Nicolas_upshifts" /id="U1864" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.597402597402597" /psig=1 /xcortree=665 /SigmaFactorBS="cccgcgaggctgaaggcggagctcttaTTTGACAAtttgtga tgacgTTGTATAATAAAACGTAATCattacgttttataaggagatgttaattatgaga g" /listShort="S903" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2174191..2174198) /Source="Nicolas_upshift_promotors" /id="U1864" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.597402597402597" /psig=1 /xcortree=665 /SigmaFactorBS="cccgcgaggctgaaggcggagctcttaTTTGACAAtttgtga tgacgTTGTATAATAAAACGTAATCattacgttttataaggagatgttaattatgaga g" /listShort="S903" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2174213..2175136) /gene="rnz" /locus_tag="BSU_23840" /old_locus_tag="BSU23840" /EC_number="3.1.26.11" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12682299, 12941704, 16336119, 17005971" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 12941704, 16336119, 17005971; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease Z" /protein_id="NP_390265.1" /db_xref="EnsemblGenomes-Gn:BSU23840" /db_xref="EnsemblGenomes-Tr:CAB14316" /db_xref="GOA:P54548" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR013471" /db_xref="InterPro:IPR036866" /db_xref="PDB:1Y44" /db_xref="PDB:2FK6" /db_xref="PDB:4GCW" /db_xref="SubtiList:BG11740" /db_xref="UniProtKB/Swiss-Prot:P54548" /translation="MELLFLGTGAGIPAKARNVTSVALKLLEERRSVWLFDCGEATQH QILHTTIKPRKIEKIFITHMHGDHVYGLPGLLGSRSFQGGEDELTVYGPKGIKAFIET SLAVTKTHLTYPLAIQEIEEGIVFEDDQFIVTAVSVIHGVEAFGYRVQEKDVPGSLKA DVLKEMNIPPGPVYQKIKKGETVTLEDGRIINGNDFLEPPKKGRSVVFSGDTRVSDKL KELARDCDVLVHEATFAKEDRKLAYDYYHSTTEQAAVTAKEARAKQLILTHISARYQG DASLELQKEAVDVFPNSVAAYDFLEVNVPRG*" /label="rnz CDS" gene complement(2174213..2175136) /gene="rnz" /locus_tag="BSU_23840" /old_locus_tag="BSU23840" /label="rnz gene" promotor_-10 complement(2175162..2175181) /Source="Nicolas_upshift_promotors" /id="U1865" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2380 /SigmaFactorBS="tctagcacgaaaggattgttcttttcagaggcaagATTCACa ttttccgcttgaTCCTGTATTCTTGTAGGTATctggttctagtaggaggaaggaaacg t" /listShort="rnz, S903" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2175175) /Source="Nicolas_upshifts" /id="U1865" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2380 /SigmaFactorBS="tctagcacgaaaggattgttcttttcagaggcaagATTCACa ttttccgcttgaTCCTGTATTCTTGTAGGTATctggttctagtaggaggaaggaaacg t" /listShort="rnz, S903" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2175195..2175200) /Source="Nicolas_upshift_promotors" /id="U1865" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2380 /SigmaFactorBS="tctagcacgaaaggattgttcttttcagaggcaagATTCACa ttttccgcttgaTCCTGTATTCTTGTAGGTATctggttctagtaggaggaaggaaacg t" /listShort="rnz, S903" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2175274..2175281 /Source="Nicolas_upshift_promotors" /id="U1866" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.676323676323676" /psig=1 /xcortree=2347 /SigmaFactorBS="acattttttcagcattctgcttaaaaaagggcttaaaTGTTT GCTttcgttgaattttAGATTTAAAATGAAGGAAATatacggggtgtactaaaataaa g" /listShort="S904, zwf" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2175295..2175314 /Source="Nicolas_upshift_promotors" /id="U1866" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.676323676323676" /psig=1 /xcortree=2347 /SigmaFactorBS="acattttttcagcattctgcttaaaaaagggcttaaaTGTTT GCTttcgttgaattttAGATTTAAAATGAAGGAAATatacggggtgtactaaaataaa g" /listShort="S904, zwf" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2175297..2175362 /Source="Nicolas_S_feature" /locus_tag="new_2479090_2479155" /HighExp="dia5, C90, MG 5, Lbexp, MG t5, MG 45, M9-exp, GM 90, GM 120, GM-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S904" upshifts 2175297 /Source="Nicolas_upshifts" /id="U1866" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.676323676323676" /psig=1 /xcortree=2347 /SigmaFactorBS="acattttttcagcattctgcttaaaaaagggcttaaaTGTTT GCTttcgttgaattttAGATTTAAAATGAAGGAAATatacggggtgtactaaaataaa g" /listShort="S904, zwf" /GFF_Attribute="listLong" /label="upshifts" CDS 2175363..2176832 /gene="zwf" /locus_tag="BSU_23850" /old_locus_tag="BSU23850" /EC_number="1.1.1.49" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1704005, 19779711, 26129872" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1704005, 19779711, 26129872; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucose-6-phosphate 1-dehydrogenase (NADP-dependent)" /protein_id="NP_390266.2" /db_xref="EnsemblGenomes-Gn:BSU23850" /db_xref="EnsemblGenomes-Tr:CAB14317" /db_xref="GOA:P54547" /db_xref="InterPro:IPR001282" /db_xref="InterPro:IPR019796" /db_xref="InterPro:IPR022674" /db_xref="InterPro:IPR022675" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11739" /db_xref="UniProtKB/Swiss-Prot:P54547" /translation="MKTNQQPKAVIVIFGATGDLAKRKLYPSIHRLYQNGQIGEEFAV VGVGRRPWSNEDLRQTVKTSISSSADKHIDDFTSHFYYHPFDVTNPGSYQELNVLLNQ LEDTYQIPNNRMFYLAMAPEFFGTIAKTLKSEGVTATTGWSRLVIEKPFGHDLPSAQA LNKEIREAFTEDQIYRIDHYLGKQMVQNIEVIRFANAIFEPLWTNRYISNIQITSSES LGVEDRARYYEKSGALRDMVQNHIMQMVALLAMEPPIKLNTEEIRSEKVKVLRALRPI AKDEVDEYFVRGQYHAGEIDGVPVPAYTDEDNVAPDSNTETFVAGKLLIDNFRWAGVP FYIRTGKRMKEKSTKIVVQFKDIPMNLYYGNENNMNPNLLVIHIQPDEGITLYLNAKK LGGAAHAQPIKLDYCSNCNDELNTPEAYEKLIHDCLLGDATNFAHWDEVALSWSFVDS ISETWAANKTLSPNYESGSMGPKESDDLLVKDGLHWWNI*" /label="zwf CDS" gene 2175363..2176832 /gene="zwf" /locus_tag="BSU_23850" /old_locus_tag="BSU23850" /label="zwf gene" downshifts 2176815 /Source="Nicolas_upshifts" /id="D1244" /incds=0 /nref=206 /ntot=286 /MaxReadThrough="3.46838" /MaxDrop="7.76173" /score="1.1363172" /energy="-15.2" /TU="U1866" /idTUdmin="U1866" /TUdmin="-90" /isTUend="FALSE" /label="downshifts" terminator 2176840..2176879 /created_by="User" /comment="zwf-T-gndA_terminator_improvement" /modified_by="User" /label="Delta6_zwf-T-gndA_Terminator" Polymorphism join(2176852,2176855) /Source="geneious" /ID="SNP_BsDelta6_2480646_2480647" /Polymorphism_Type="Substitution" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=2 /Amino_Acid_Change /CDS_Position /Change="TA -> AT" /Codon_Change /Coverage=115 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides="TA" /Variant_Nucleotides="AT" /Variant_P_Value=0 /Variant_Raw_Frequency=113 /comment="zwf-T-gndA_terminator_improvement" /modified_by="User" / /label="Polymorphism_Delta6" Polymorphism join(2176860,2176861) /Source="geneious" /ID="SNP_BsDelta6_2480654_2480654" /Polymorphism_Type="Deletion" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change /CDS_Position /Change="-T" /Codon_Change /Coverage=115 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides /Variant_P_Value="2.1e-279" /Variant_Raw_Frequency=113 /comment="zwf-T-gndA_terminator_improvement" /modified_by="User" / /label="Polymorphism_Delta6" Polymorphism join(2176872,2176873) /Source="geneious" /ID="SNP_BsDelta6_2480667_2480667" /Polymorphism_Type="Deletion" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change /CDS_Position /Change="-T" /Codon_Change /Coverage=116 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides /Variant_P_Value="2.9e-244" /Variant_Raw_Frequency=110 /comment="zwf-T-gndA_terminator_improvement" /modified_by="User" / /label="Polymorphism_Delta6" downshifts 2176881 /Source="Nicolas_upshifts" /id="D1245" /incds=0 /nref=1 /ntot=104 /MaxReadThrough="2.5392" /MaxDrop="4.74183" /score="1.1363172" /energy="-15.2" /TU="U1866" /idTUdmin="U1866" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(2176955..2178364) /gene="gndA" /locus_tag="BSU_23860" /old_locus_tag="BSU23860" /EC_number="1.1.1.44" /function="16.2: Construct biomass (Anabolism)" /function="16.7: Manage energy" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15231785, 15755726" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15231785, 15755726; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADP+-dependent 6-P-gluconate dehydrogenase" /protein_id="NP_390267.2" /db_xref="EnsemblGenomes-Gn:BSU23860" /db_xref="EnsemblGenomes-Tr:CAB14318" /db_xref="GOA:P80859" /db_xref="InterPro:IPR006113" /db_xref="InterPro:IPR006114" /db_xref="InterPro:IPR006115" /db_xref="InterPro:IPR006183" /db_xref="InterPro:IPR006184" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11738" /db_xref="UniProtKB/Swiss-Prot:P80859" /translation="MSKQQIGVIGLAVMGKNLALNIESRGFSVSVYNRSSSKTEEFLQ EAKGKNVVGTYSIEEFVQSLETPRKILLMVKAGTATDATIQSLLPHLEKDDILIDGGN TYYKDTQRRNKELAESGIHFIGTGVSGGEEGALKGPSIMPGGQKEAHELVKPILEAIS AKVDGEPCTTYIGPDGAGHYVKMVHNGIEYGDMQLISESYFILKQVLGLSADELHEVF AEWNKGELDSYLIEITADIFTKKDEETGKPLVDVILDKAGQKGTGKWTSQSALDLGVP LPIITESVFARFISAMKEERVKASGLLSGPEVKPVTENKEELIEAVRKALFMSKICSY AQGFAQMKAASEEYNWDLKYGEIAMIFRGGCIIRAAFLQKIKEAYDREPELDNLLLDS YFKNIVESYQGALRQVISLAVAQGVPVPSFSSALAYYDSYRTAVLPANLIQAQRDYFG AHTYERTDKEGIFHTEWMK*" /label="gndA CDS" gene complement(2176955..2178364) /gene="gndA" /locus_tag="BSU_23860" /old_locus_tag="BSU23860" /label="gndA gene" downshifts complement(2176972) /Source="Nicolas_upshifts" /id="D1246" /incds=0 /nref=220 /ntot=361 /MaxReadThrough="1.88983" /MaxDrop="8.82894" /score="24.3727084" /energy="-18" /TU="NA" /idTUdmin="U1867" /TUdmin="-15" /isTUend="TRUE" /label="downshifts" downshifts complement(2177045) /Source="Nicolas_upshifts" /id="D1247" /incds=1 /nref=1 /ntot=36 /MaxReadThrough="8.40595" /MaxDrop="2.3555" /score="24.3727084" /energy="-18" /TU="U1867" /idTUdmin="U1867" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" misc_feature complement(2178428..2178446) /Source="Nicolas_upshift_promotors" /id="U1867" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.377622377622378" /psig="0.987012987012987" /xcortree=2358 /SigmaFactorBS="atgaaaagaaaagctgaatcgcttgaaaaaaagggtgaatgt atGGTAATTTCTTTATTATAAatatcattttattttaatttaaattttaaaatgatta a" /listShort="gndA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2178430) /Source="Nicolas_upshifts" /id="U1867" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.377622377622378" /psig="0.987012987012987" /xcortree=2358 /SigmaFactorBS="atgaaaagaaaagctgaatcgcttgaaaaaaagggtgaatgt atGGTAATTTCTTTATTATAAatatcattttattttaatttaaattttaaaatgatta a" /listShort="gndA" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2178474..2179718) /gene="polYA" /locus_tag="BSU_23870" /old_locus_tag="BSU23870" /EC_number="2.7.7.7" /function="16.6: Maintain" /function="16.5: Explore" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:12137951, 12644484, 15469515, 16045613, 25713353" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12137951, 12644484, 15469515, 16045613, 25713353; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA-damage lesion bypass DNA polymerase" /protein_id="NP_390268.2" /db_xref="EnsemblGenomes-Gn:BSU23870" /db_xref="EnsemblGenomes-Tr:CAB14319" /db_xref="GOA:P54545" /db_xref="InterPro:IPR001126" /db_xref="InterPro:IPR017061" /db_xref="InterPro:IPR017961" /db_xref="InterPro:IPR022880" /db_xref="InterPro:IPR024728" /db_xref="InterPro:IPR036775" /db_xref="SubtiList:BG11737" /db_xref="UniProtKB/Swiss-Prot:P54545" /translation="MPGKSRIIFHIDMNSFYASVEMAYDPALRGKPVAVAGNVKERKG IVVTCSYEARARGVKTTMPVWQAKRHCPELIVLPPNFDRYRNSSRAMFTILREYTDLV EPVSIDEGYMDMTDTPYSSRALETAKEIQSRLQKELLLPSSIGIAPNKFLAKMASDMK KPLGITILRKRQVPDILWPLPVGEMHGVGKKTAEKLKGLGIHTIGELAAADEHSLKRL LGINGPRLKNKANGIHHAPVDPERIYEFKSVGNSSTLSHDSSDEEELLGVFRKLAASV SDRLQRKEVMASKLFIMIRYADWRTITRSTTLRNPIDQKNDILKEAEHLFFKHWNKNP VRLLGITGTDLVEKEQAYKQLDLFSFNEDAKDEPIQQMMEKLNKKYGTKLIRKGATLK KEESKTKGTSFNKDFFQDEKKS*" /label="polYA CDS" gene complement(2178474..2179718) /gene="polYA" /locus_tag="BSU_23870" /old_locus_tag="BSU23870" /label="polYA gene" S_feature complement(2179719..2179993) /Source="Nicolas_S_feature" /locus_tag="new_2483514_2483788_c" /HighExp="M40t90, Sw, M40t45, H2O2, C30, Cold, Etha, C90, Diami, BC" /AntisenseName="yqzJ" /AntisenseCor="0.48883700687558601" /AntisenseRegPval="-16.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S905" promotor_-35 2179739..2179746 /Source="Nicolas_upshift_promotors" /id="U1868" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.635364635364635" /psig="0.994005994005994" /xcortree=2144 /SigmaFactorBS="ttcggctctttcccggcataaacaaatctccttttcggtCAT TAGACaacagcttgtacaTATAGTAAAATGAAGCTATTgaatggatgtgatgacaatg t" /listShort="yqzJ, oxaAB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2179760..2179779 /Source="Nicolas_upshift_promotors" /id="U1868" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.635364635364635" /psig="0.994005994005994" /xcortree=2144 /SigmaFactorBS="ttcggctctttcccggcataaacaaatctccttttcggtCAT TAGACaacagcttgtacaTATAGTAAAATGAAGCTATTgaatggatgtgatgacaatg t" /listShort="yqzJ, oxaAB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2179760 /Source="Nicolas_upshifts" /id="U1868" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.635364635364635" /psig="0.994005994005994" /xcortree=2144 /SigmaFactorBS="ttcggctctttcccggcataaacaaatctccttttcggtCAT TAGACaacagcttgtacaTATAGTAAAATGAAGCTATTgaatggatgtgatgacaatg t" /listShort="yqzJ, oxaAB" /GFF_Attribute="listLong" /label="upshifts" CDS 2179791..2180078 /gene="mifM" /locus_tag="BSU_23880" /old_locus_tag="BSU23880" /experiment="publication(s) with functional evidences, PMID:19779460, 21383133, 22720735, 25313395, 25903689" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19779460, 21383133, 22720735, 25313395, 25903689; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of OxaAB translation" /protein_id="YP_054586.1" /db_xref="EnsemblGenomes-Gn:BSU23880" /db_xref="EnsemblGenomes-Tr:CAE01460" /db_xref="GOA:Q7WY64" /db_xref="PDB:3J9W" /db_xref="SubtiList:BG14191" /db_xref="UniProtKB/Swiss-Prot:Q7WY64" /translation="MTMFVESINDVLFLVDFFTIILPALTAIGIAFLLRECRAGEQWK SKRTDEHQTVFHINRTDFLIIIYHRITTWIRKVFRMNSPVNDEEDAGSLLL*" /label="mifM CDS" gene 2179791..2180078 /gene="mifM" /locus_tag="BSU_23880" /old_locus_tag="BSU23880" /label="mifM gene" promotor_-10 complement(2179975..2179994) /Source="Nicolas_upshift_promotors" /id="U1869" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.554445554445554" /psig="0.993006993006993" /xcortree=2094 /SigmaFactorBS="cttcctcatcgttcacaggcgaattcatgcggaagactttac GTATccaagttgtaatgcgATGATATATAATAATAAGAAagtctgttcggttaatgtg a" /listShort="S905, polYA" /listLong="gndA" /label="promotor_-10" upshifts complement(2179995) /Source="Nicolas_upshifts" /id="U1869" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.554445554445554" /psig="0.993006993006993" /xcortree=2094 /SigmaFactorBS="cttcctcatcgttcacaggcgaattcatgcggaagactttac GTATccaagttgtaatgcgATGATATATAATAATAAGAAagtctgttcggttaatgtg a" /listShort="S905, polYA" /listLong="gndA" /label="upshifts" promotor_-35 complement(2180010..2180013) /Source="Nicolas_upshift_promotors" /id="U1869" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.554445554445554" /psig="0.993006993006993" /xcortree=2094 /SigmaFactorBS="cttcctcatcgttcacaggcgaattcatgcggaagactttac GTATccaagttgtaatgcgATGATATATAATAATAAGAAagtctgttcggttaatgtg a" /listShort="S905, polYA" /listLong="gndA" /label="promotor_-35" CDS 2180109..2180936 /gene="oxaAB" /locus_tag="BSU_23890" /old_locus_tag="BSU23890" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11889108, 15654078, 15671040, 15849754, 16293689, 16850406, 21204254, 24443530, 24739968, 25903689" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11889108, 15654078, 15671040, 15849754, 16293689, 16850406, 21204254, 24443530, 24739968, 25903689; Product type f: factor" /codon_start=1 /transl_table=11 /product="Sec-independent factor for membrane protein insertion (YidC/SpoIIIJ family)" /protein_id="NP_390269.1" /db_xref="EnsemblGenomes-Gn:BSU23890" /db_xref="EnsemblGenomes-Tr:CAB14320" /db_xref="GOA:P54544" /db_xref="InterPro:IPR001708" /db_xref="InterPro:IPR023060" /db_xref="InterPro:IPR028055" /db_xref="SubtiList:BG11736" /db_xref="UniProtKB/Swiss-Prot:P54544" /translation="MLKTYQKLLAMGIFLIVLCSGNAAFAATNQVGGLSNVGFFHDYL IEPFSALLKGVAGLFHGEYGLSIILVTIIVRIVVLPLFVNQFKKQRIFQEKMAVIKPQ VDSIQVKLKKTKDPEKQKELQMEMMKLYQEHNINPLAMGCLPMLIQSPIMIGLYYAIR STPEIASHSFLWFSLGQSDILMSLSAGIMYFVQAYIAQKLSAKYSAVPQNPAAQQSAK LMVFIFPVMMTIFSLNVPAALPLYWFTSGLFLTVQNIVLQMTHHKSKKTAALTESVK* " /label="oxaAB CDS" gene 2180109..2180936 /gene="oxaAB" /locus_tag="BSU_23890" /old_locus_tag="BSU23890" /label="oxaAB gene" downshifts 2180753 /Source="Nicolas_upshifts" /id="D1248" /incds=1 /nref=4 /ntot=125 /MaxReadThrough="5.05074" /MaxDrop="3.49092" /score="-5.67811369" /energy="-7.6" /TU="U1868" /idTUdmin="U1868" /TUdmin="-176" /isTUend="FALSE" /label="downshifts" downshifts 2180929 /Source="Nicolas_upshifts" /id="D1249" /incds=0 /nref=71 /ntot=229 /MaxReadThrough="1.09826" /MaxDrop="6.56698" /score="-5.67811369" /energy="-7.6" /TU="NA" /idTUdmin="U1868" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2180941..2181861) /Source="Nicolas_S_feature" /locus_tag="new_2484736_2485656_c" /HighExp="LoTm, B36, M0t90, M40t90, Lbstat, M9-stat, T1.30H, B60, LBGtran, BT" /AntisenseName="yqjF" /AntisenseCor="0.18628881890353799" /AntisenseRegPval="-2.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S906" downshifts complement(2180984) /Source="Nicolas_upshifts" /id="D1250" /incds=0 /nref=170 /ntot=248 /MaxReadThrough="0.24428" /MaxDrop="6.31082" /score="18.1943524" /energy="-12.4" /TU="NA" /idTUdmin="U1871" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 2181054..2181060 /Source="Nicolas_upshift_promotors" /id="U1870" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=161 /SigmaFactorBS="cagaaatggccatcctaaaaaatagccgtatCGTTTAAaaag aaggaaatcGGGAATACCTTTACTCACCtccaaccgaaaggagcctatacgttgacgg a" /listShort="yqjF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2181074..2181092 /Source="Nicolas_upshift_promotors" /id="U1870" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=161 /SigmaFactorBS="cagaaatggccatcctaaaaaatagccgtatCGTTTAAaaag aaggaaatcGGGAATACCTTTACTCACCtccaaccgaaaggagcctatacgttgacgg a" /listShort="yqjF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2181083 /Source="Nicolas_upshifts" /id="U1870" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=161 /SigmaFactorBS="cagaaatggccatcctaaaaaatagccgtatCGTTTAAaaag aaggaaatcGGGAATACCTTTACTCACCtccaaccgaaaggagcctatacgttgacgg a" /listShort="yqjF" /GFF_Attribute="listLong" /label="upshifts" CDS 2181116..2181844 /gene="yqjF" /locus_tag="BSU_23900" /old_locus_tag="BSU23900" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390270.3" /db_xref="EnsemblGenomes-Gn:BSU23900" /db_xref="EnsemblGenomes-Tr:CAB14321" /db_xref="InterPro:IPR018644" /db_xref="InterPro:IPR023375" /db_xref="SubtiList:BG11735" /db_xref="UniProtKB/Swiss-Prot:P54543" /translation="MTERFQQKNISVPDGIWIMRQTWNDVLFAHWPVDVSILRALVPS VLELDTYNGQAWISMLPFMLTNLRARYLPVIPGARAFPELNLRTYVTYKGKPGIYFFS LDADHRLAVLGARTFFHLPYFYADMKSEKNGDAIDYVSKRKNDKEAAFHAAYRPISAP FTAEKDSLDYWLTERYRLYTTYRNKLYYEDIHHHPWLLQNAEAEISVNTVTDAHGITL PESDPLLHYAKKQDVLFWPLRKWS*" /label="yqjF CDS" gene 2181116..2181844 /gene="yqjF" /locus_tag="BSU_23900" /old_locus_tag="BSU23900" /label="yqjF gene" CDS complement(2181885..2183000) /gene="yqjE" /locus_tag="BSU_23910" /old_locus_tag="BSU23910" /function="16.5: Explore" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative peptidase or deacylase" /protein_id="NP_390271.2" /db_xref="EnsemblGenomes-Gn:BSU23910" /db_xref="EnsemblGenomes-Tr:CAB14322" /db_xref="GOA:P54542" /db_xref="InterPro:IPR001261" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR008007" /db_xref="InterPro:IPR010162" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG11734" /db_xref="UniProtKB/Swiss-Prot:P54542" /translation="MVNEKRLLEEFLELVQIDSETKHEAEICKVLKRKFSDLGVDVKE DDTMDITGHGAGNLICTLKGTKQTDTIYFTSHMDTVVPGNGVKPVVENGYVKTDGTTI LGADDKAGLAAMFEAIKVLKEENIEHGTIEFIITVGEESGLIGAKALDRSMITASYGY ALDSDGKVGNIIVAAPTQAKVRAAIFGKTAHAGVEPEKGISAITIASKAISKMPLGRI DEETTANIGRFEGGTQTNIVCDEVHILAEARSLVPEKMEAQVQKMKAAFEEAAADMGG RAEVEIEVMYPGFKYQDGDQVVEIAKKAAAKIGRPSELQTSGGGSDANVIAGHGIPTV NLAVGYEQIHTKNEKMPIEELVKTAEMVVAIIEEAAK*" /label="yqjE CDS" gene complement(2181885..2183000) /gene="yqjE" /locus_tag="BSU_23910" /old_locus_tag="BSU23910" /label="yqjE gene" downshifts complement(2181906) /Source="Nicolas_upshifts" /id="D1251" /incds=0 /nref=23 /ntot=203 /MaxReadThrough="3.90071" /MaxDrop="3.95711" /score="11.6635037" /energy="-10.6" /TU="U1871" /idTUdmin="U1871" /TUdmin="-923" /isTUend="FALSE" /label="downshifts" CDS complement(2183018..2184541) /gene="yqjD" /locus_tag="BSU_23920" /old_locus_tag="BSU23920" /EC_number="6.4.1.3" /function="16.5: Explore" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative propionyl-CoA carboxylase beta chain" /protein_id="NP_390272.2" /db_xref="EnsemblGenomes-Gn:BSU23920" /db_xref="EnsemblGenomes-Tr:CAB14323" /db_xref="GOA:P54541" /db_xref="InterPro:IPR000438" /db_xref="InterPro:IPR011762" /db_xref="InterPro:IPR011763" /db_xref="InterPro:IPR029045" /db_xref="InterPro:IPR034733" /db_xref="SubtiList:BG11733" /db_xref="UniProtKB/Swiss-Prot:P54541" /translation="MNEHMDHFYTKRKQAEEGGGREKLAQQRQKGKLTARERIIFLLD QDSFIELHPFMESQVLTREQRMLGDGVVTGYGTIDGRSVYVFAQDFTVYGGALGETHA RKICALMDLAAKNKAPIIGLNDSGGARIQEGVLSLDGYGHIFYRNVLYSGVIPQISVI LGPCAGGAVYSPALTDFIFMAEQTGRMFITGPKVIEKVTGEQVDAESLGGAGIHNAVS GNAHFSGHTEKEVLTGVRKLLSYLPLNGRTTEPKPEKEASRPLLNRLVPADTTKPYDV RKVIRELADPQSFFEIQPFFAKNIVIGFARLGEKAIGIVASQPKHLAGSLTIDAADKA ARFIRFCDAFDIPLLTVEDVPGFLPGIQQEHNGIIRHGAKLLFAYAEATVPKVTLIIR KAYGGAYVAMNSKAIGADLVFAWPNAEIAVMGPEGAASILYEKEIKASADPQKTKREK TAEYKKQNAGPYKAAACGMVDDIILPEESRGRLIQAFHMLTHKTEERPKKKHGNIPL* " /label="yqjD CDS" gene complement(2183018..2184541) /gene="yqjD" /locus_tag="BSU_23920" /old_locus_tag="BSU23920" /label="yqjD gene" promotor_-10 complement(2184124..2184143) /Source="Nicolas_upshift_promotors" /id="U1871" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.504495504495505" /psig="0.999000999001" /xcortree=1916 /SigmaFactorBS="agcaaaaaataaggcgccgattatcgggctgaatgactcagg tgGTGCGagaattcaagagggTGTGTTATCATTAGATGGATacggtcacatattttac c" /listShort="yqjE, S906" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2184146) /Source="Nicolas_upshifts" /id="U1871" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.504495504495505" /psig="0.999000999001" /xcortree=1916 /SigmaFactorBS="agcaaaaaataaggcgccgattatcgggctgaatgactcagg tgGTGCGagaattcaagagggTGTGTTATCATTAGATGGATacggtcacatattttac c" /listShort="yqjE, S906" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2184158..2184162) /Source="Nicolas_upshift_promotors" /id="U1871" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.504495504495505" /psig="0.999000999001" /xcortree=1916 /SigmaFactorBS="agcaaaaaataaggcgccgattatcgggctgaatgactcagg tgGTGCGagaattcaagagggTGTGTTATCATTAGATGGATacggtcacatattttac c" /listShort="yqjE, S906" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2184534..2184956) /gene="yqjC" /locus_tag="BSU_23930" /old_locus_tag="BSU23930" /EC_number="5.1.99.1" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative methylmalonyl-CoA epimerase" /protein_id="NP_390273.2" /db_xref="EnsemblGenomes-Gn:BSU23930" /db_xref="EnsemblGenomes-Tr:CAB14324" /db_xref="GOA:P54540" /db_xref="InterPro:IPR017515" /db_xref="InterPro:IPR018146" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG11732" /db_xref="UniProtKB/Swiss-Prot:P54540" /translation="MNRLDHIGIAVFSIKDARSFYENVLGLAFLHQETVEEQKVNVAF FQAGSVKLELIEPLTADSPVHLFLEKKGQGLHHIAFLCNCLSEQLQALSDQHVQLIDR FPRQGANGKKIAFISPRETNGVLVELCEPKGDQHNEHE*" /label="yqjC CDS" gene complement(2184534..2184956) /gene="yqjC" /locus_tag="BSU_23930" /old_locus_tag="BSU23930" /label="yqjC gene" promotor_-35 2184985..2184992 /Source="Nicolas_upshift_promotors" /id="U1872" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=1904 /SigmaFactorBS="catccctgctttcgctaatagatatCGCTTGTCcgcccattc aaaaCACGCTAAAATATAGACAGAttgtttaaggagtgaaaatcatgtctcaaaaact g" /listShort="S907, S908" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2185006..2185025 /Source="Nicolas_upshift_promotors" /id="U1872" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=1904 /SigmaFactorBS="catccctgctttcgctaatagatatCGCTTGTCcgcccattc aaaaCACGCTAAAATATAGACAGAttgtttaaggagtgaaaatcatgtctcaaaaact g" /listShort="S907, S908" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2185020..2185173 /Source="Nicolas_S_feature" /locus_tag="new_2488815_2488968" /HighExp="LPhT, Etha, dia15, Salt, M9-stat, LBGstat, Heat, BC, T-0.40H, HiOs" /AntisenseName="yqjB" /AntisenseCor="-0.57221813594264503" /AntisenseRegPval="-24.1" /CDS_PredictionProba="0.99822200000000005" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S907" upshifts 2185020 /Source="Nicolas_upshifts" /id="U1872" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=1904 /SigmaFactorBS="catccctgctttcgctaatagatatCGCTTGTCcgcccattc aaaaCACGCTAAAATATAGACAGAttgtttaaggagtgaaaatcatgtctcaaaaact g" /listShort="S907, S908" /GFF_Attribute="listLong" /label="upshifts" downshifts 2185130 /Source="Nicolas_upshifts" /id="D1252" /incds=0 /nref=1 /ntot=140 /MaxReadThrough="3.88708" /MaxDrop="3.25163" /score="3.10927996" /energy="-7" /TU="U1872" /idTUdmin="U1872" /TUdmin="-638" /isTUend="FALSE" /label="downshifts" CDS complement(2185158..2185688) /gene="yqjB" /locus_tag="BSU_23940" /old_locus_tag="BSU23940" /EC_number="2.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative L,D-transpeptidase" /protein_id="NP_390274.1" /db_xref="EnsemblGenomes-Gn:BSU23940" /db_xref="EnsemblGenomes-Tr:CAB14325" /db_xref="GOA:P54539" /db_xref="InterPro:IPR005490" /db_xref="SubtiList:BG11731" /db_xref="UniProtKB/Swiss-Prot:P54539" /translation="MRFFLCSIFMMISPIWPLGENPLPGDPYVIVNKRTNELAVILDN KVEGVYSVATGKTDDLTPEGEFSVTVKAENPYYRKKNIEGGSPDNPLGARWIGFDAKG TDGRIYGIHGTNREESVGKFVSNGCIRMHNDEVVHLFQTIPVGTRVLITDDNRSFEEI AIEHKALIKKQDIPIE*" /label="yqjB CDS" gene complement(2185158..2185688) /gene="yqjB" /locus_tag="BSU_23940" /old_locus_tag="BSU23940" /label="yqjB gene" S_feature 2185175..2185810 /Source="Nicolas_S_feature" /locus_tag="new_2488970_2489605" /HighExp="LPhT, H2O2, BC, Salt, dia15, M9-stat, Heat, LBGstat, T5.0H, Etha" /AntisenseName="yqjB" /AntisenseCor="-0.31126010332536502" /AntisenseRegPval="-6.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S908" promotor_-10 complement(2185705..2185716) /Source="Nicolas_upshift_promotors" /id="U1873" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=825 /SigmaFactorBS="aaaggaataaaagcgcaaaaatcactcggatgattCGCATGA gctcttccttcattGGTCAACCTAATgaaaaaggaggagcttatgcgttttttcttat g" /listShort="yqjB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2185712) /Source="Nicolas_upshifts" /id="U1873" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=825 /SigmaFactorBS="aaaggaataaaagcgcaaaaatcactcggatgattCGCATGA gctcttccttcattGGTCAACCTAATgaaaaaggaggagcttatgcgttttttcttat g" /listShort="yqjB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2185731..2185737) /Source="Nicolas_upshift_promotors" /id="U1873" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=825 /SigmaFactorBS="aaaggaataaaagcgcaaaaatcactcggatgattCGCATGA gctcttccttcattGGTCAACCTAATgaaaaaggaggagcttatgcgttttttcttat g" /listShort="yqjB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2185740..2186708) /gene="yqjA" /locus_tag="BSU_23950" /old_locus_tag="BSU23950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390275.2" /db_xref="EnsemblGenomes-Gn:BSU23950" /db_xref="EnsemblGenomes-Tr:CAB14326" /db_xref="GOA:P54538" /db_xref="InterPro:IPR010343" /db_xref="InterPro:IPR021062" /db_xref="SubtiList:BG11730" /db_xref="UniProtKB/Swiss-Prot:P54538" /translation="MFKIGYRTIKTALGTALAIYISQLLHLQNFASAGIITILCIQIT QKRSLQASWARFSACCLAIAFSYLFFELIGYHPFVIGALLLIFIPITVLLKINEGIVT SSVIILHLYMSGGITPTFIWNEVQLITVGIGVALLMNLYMPSLDRKLIAYRKKIEDNF AVIFAEIERYLLTGEQDWSGKEIPETHQLITEAKNLAYRDVQNHILRYENLHYHYFKM REKQFEIIERLLPKVTSISITVDQGKMIAEFIHDLREAIHPGNTAYKFLKRLADMRKE FEEMPLPATREEFEARAALFHLLGEMEQYLVIKSYFKGIKAQKSLG*" /label="yqjA CDS" gene complement(2185740..2186708) /gene="yqjA" /locus_tag="BSU_23950" /old_locus_tag="BSU23950" /label="yqjA gene" downshifts complement(2185756) /Source="Nicolas_upshifts" /id="D1253" /incds=0 /nref=79 /ntot=223 /MaxReadThrough="2.22356" /MaxDrop="3.94894" /score="1.98299685" /energy="-14.1" /TU="NA" /idTUdmin="U1874" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2186779..2187501) /gene="artR" /locus_tag="BSU_23960" /old_locus_tag="BSU23960" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008; Product type t: transporter" /codon_start=1 /transl_table=11 /product="high affinity arginine ABC transporter (ATP-binding protein)" /protein_id="NP_390276.1" /db_xref="EnsemblGenomes-Gn:BSU23960" /db_xref="EnsemblGenomes-Tr:CAB14327" /db_xref="GOA:P54537" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030679" /db_xref="SubtiList:BG11729" /db_xref="UniProtKB/Swiss-Prot:P54537" /translation="MIKVEKLSKSFGKHEVLKNISTTIAEGEVVAVIGPSGSGKSTFL RCLNLLEKPNGGTITIKDTEITKPKTNTLKVRENIGMVFQHFHLFPHKTVLENIMYAP VNVKKESKQAAQEKAEDLLRKVGLFEKRNDYPNRLSGGQKQRVAIARALAMNPDIMLF DEPTSALDPEMVKEVLQVMKELVETGMTMVIVTHEMGFAKEVADRVLFMDQGMIVEDG NPKEFFMSPKSKRAQDFLEKIL*" /label="artR CDS" gene complement(2186779..2187501) /gene="artR" /locus_tag="BSU_23960" /old_locus_tag="BSU23960" /label="artR gene" downshifts complement(2186790) /Source="Nicolas_upshifts" /id="D1254" /incds=0 /nref=30 /ntot=152 /MaxReadThrough="4.81216" /MaxDrop="4.0342" /score="0.346345754" /energy="-7" /TU="U1874" /idTUdmin="U1874" /TUdmin="-1034" /isTUend="FALSE" /label="downshifts" CDS complement(2187494..2188153) /gene="artQ" /locus_tag="BSU_23970" /old_locus_tag="BSU23970" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="high affinity arginine ABC transporter (permease)" /protein_id="NP_390277.1" /db_xref="EnsemblGenomes-Gn:BSU23970" /db_xref="EnsemblGenomes-Tr:CAB14328" /db_xref="GOA:P54536" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR010065" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11728" /db_xref="UniProtKB/Swiss-Prot:P54536" /translation="MNLDFSATIPQIPFILEGLAITLKIVVVSAIIGLILGIVLSLCK ISTFRPFIWIADFYTSVFRGTPLVLQLMIVYFGLPQLLGFQIDQFWAAVVALSLNSAA YVSEIIRAGINAIDKGQKEAAVALGVPYGKMMKDLLLPQAFKNISPAIVNELITLTKE SAIVTVIGLGDVMRRAYQAGAATYNYLEPLIIAGLIYYVLVLILTFIGKAVERKLKSN D*" /label="artQ CDS" gene complement(2187494..2188153) /gene="artQ" /locus_tag="BSU_23970" /old_locus_tag="BSU23970" /label="artQ gene" S_feature complement(2188154..2188233) /Source="Nicolas_S_feature" /locus_tag="new_2491949_2492028_c" /HighExp="S1, S2, ferm, MG 15, Fru, Glu, BMM, S3, UNK1, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S909" CDS complement(2188234..2189001) /gene="artP" /locus_tag="BSU_23980" /old_locus_tag="BSU23980" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008; Product type t: transporter" /codon_start=1 /transl_table=11 /product="high affinity arginine ABC transporter binding lipoprotein" /protein_id="NP_390278.1" /db_xref="EnsemblGenomes-Gn:BSU23980" /db_xref="EnsemblGenomes-Tr:CAB14329" /db_xref="GOA:P54535" /db_xref="InterPro:IPR001320" /db_xref="InterPro:IPR001638" /db_xref="InterPro:IPR018313" /db_xref="SubtiList:BG11727" /db_xref="UniProtKB/Swiss-Prot:P54535" /translation="MKKWLLLLVAACITFALTACGSSNSGSESGKKKLIMGTSADYKP FEYKEGDNIVGFDVELAKALAKKAGYEIEVQDMDFNSLITALKSKQVDLVLSGMTPTP ERKKQVDFSDVYYTANHMIVSKKDSGIQSLKDLKGKTVGVQLGSIQEEKGKELSPEYG FKTEDRNRISDLVQEIKSDRFDAAIIEDIVAEGYFKSNDDLQGFVIPDAKAEEAGSAI AFRKDSELTDKFNKALKEMEDNGELEKLKKKWFTGEK*" /label="artP CDS" gene complement(2188234..2189001) /gene="artP" /locus_tag="BSU_23980" /old_locus_tag="BSU23980" /label="artP gene" promotor_-10 complement(2189051..2189070) /Source="Nicolas_upshift_promotors" /id="U1874" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.94105894105894" /psig=1 /xcortree=2912 /SigmaFactorBS="gaaagataagcctaaagataatttttaaaaatagTATTGCAT aaaaatgagaaactGTTTAAAATACAAATTAACGaataaatattcaaatacaccaaaa g" /listShort="artP, S909, artQ, artR, yqjA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2189066) /Source="Nicolas_upshifts" /id="U1874" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.94105894105894" /psig=1 /xcortree=2912 /SigmaFactorBS="gaaagataagcctaaagataatttttaaaaatagTATTGCAT aaaaatgagaaactGTTTAAAATACAAATTAACGaataaatattcaaatacaccaaaa g" /listShort="artP, S909, artQ, artR, yqjA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2189085..2189092) /Source="Nicolas_upshift_promotors" /id="U1874" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.94105894105894" /psig=1 /xcortree=2912 /SigmaFactorBS="gaaagataagcctaaagataatttttaaaaatagTATTGCAT aaaaatgagaaactGTTTAAAATACAAATTAACGaataaatattcaaatacaccaaaa g" /listShort="artP, S909, artQ, artR, yqjA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2189269..2189706) /gene="brxB" /locus_tag="BSU_23990" /old_locus_tag="BSU23990" /experiment="publication(s) with functional evidences, PMID:21749987, 24313874, 28301954" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21749987, 24313874, 28301954; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bacilliredoxin B (de-bacillithiolation)" /protein_id="NP_390279.1" /db_xref="EnsemblGenomes-Gn:BSU23990" /db_xref="EnsemblGenomes-Tr:CAB14330" /db_xref="InterPro:IPR009474" /db_xref="SubtiList:BG11726" /db_xref="UniProtKB/Swiss-Prot:P54534" /translation="MNMDFNLFMNDIVRQARQEITAAGYTELKTAEEVDEALTKKGTT LVMVNSVCGCAGGIARPAAYHSVHYDKRPDQLVTVFAGQDKEATARARDYFEGYPPSS PSFAILKDGKIMKMVERHEIEGHEPMAVVAKLQEAFEEYCEEV*" /label="brxB CDS" gene complement(2189269..2189706) /gene="brxB" /locus_tag="BSU_23990" /old_locus_tag="BSU23990" /label="brxB gene" downshifts complement(2189278) /Source="Nicolas_upshifts" /id="D1255" /incds=0 /nref=252 /ntot=266 /MaxReadThrough="3.9242" /MaxDrop="7.06654" /score="21.489397" /energy="-11.8" /TU="U1875" /idTUdmin="U1875" /TUdmin="-200" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2189730..2189749) /Source="Nicolas_upshift_promotors" /id="U1875" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=1935 /SigmaFactorBS="agtaaacgaagagcaaaaaaagtgcacggcgaagcaaagtCA TTTGCCgatatggacgtttcCTTGCTATCATAAGAACAGAtgatgaaaaaggagaggt c" /listShort="yqiW" /listLong="artP, S909, artQ, artR, yqjA" /label="promotor_-10" upshifts complement(2189751) /Source="Nicolas_upshifts" /id="U1875" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=1935 /SigmaFactorBS="agtaaacgaagagcaaaaaaagtgcacggcgaagcaaagtCA TTTGCCgatatggacgtttcCTTGCTATCATAAGAACAGAtgatgaaaaaggagaggt c" /listShort="yqiW" /listLong="artP, S909, artQ, artR, yqjA" /label="upshifts" promotor_-35 complement(2189764..2189771) /Source="Nicolas_upshift_promotors" /id="U1875" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=1935 /SigmaFactorBS="agtaaacgaagagcaaaaaaagtgcacggcgaagcaaagtCA TTTGCCgatatggacgtttcCTTGCTATCATAAGAACAGAtgatgaaaaaggagaggt c" /listShort="yqiW" /listLong="artP, S909, artQ, artR, yqjA" /label="promotor_-35" promotor_-35 2189804..2189810 /Source="Nicolas_upshift_promotors" /id="U1876" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=198 /SigmaFactorBS="cggcaaatgactttgcttcgccgtgcactttttttgctcttC GTTTACtgcttacagaaaaaGGGGATTATATAACCAGAAgtaaaataaaggagcagtt g" /listShort="bmrU, bmr, bmrR" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2189823 /Source="Nicolas_upshifts" /id="U1876" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=198 /SigmaFactorBS="cggcaaatgactttgcttcgccgtgcactttttttgctcttC GTTTACtgcttacagaaaaaGGGGATTATATAACCAGAAgtaaaataaaggagcagtt g" /listShort="bmrU, bmr, bmrR" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2189825..2189843 /Source="Nicolas_upshift_promotors" /id="U1876" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=198 /SigmaFactorBS="cggcaaatgactttgcttcgccgtgcactttttttgctcttC GTTTACtgcttacagaaaaaGGGGATTATATAACCAGAAgtaaaataaaggagcagtt g" /listShort="bmrU, bmr, bmrR" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2189867..2190760 /gene="bmrU" /locus_tag="BSU_24000" /old_locus_tag="BSU24000" /EC_number="2.7.1.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7961792, 8098708, 10220166, 17114254, 17535816; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative lipid kinase BmrU" /protein_id="NP_390280.2" /db_xref="EnsemblGenomes-Gn:BSU24000" /db_xref="EnsemblGenomes-Tr:CAB14331" /db_xref="GOA:P39074" /db_xref="InterPro:IPR001206" /db_xref="InterPro:IPR005218" /db_xref="InterPro:IPR016064" /db_xref="InterPro:IPR017438" /db_xref="SubtiList:BG10302" /db_xref="UniProtKB/Swiss-Prot:P39074" /translation="MSHRKALLIHNGNAGNKNIEKALGAVVPVLSHHLDEVIIKQTKK KDDAYHFCRSIDDSVDTVFILGGDGTIHQCINAISALERKPAVGILPGGTCNDFSRVL GIPQNLAKAAEALMAGKKTSVDVCQMNDRYFLNFWGIGLIAETSNQINETEKALLGKI SYFTSALRTVSSAASFPMTLKIDGEEIKEEAVMLLVMNGQYIGTNRIPLPDASIEDGL LDVLICRNTNLTALRELMSMEQGSIDRFTGELSYVQASRIEIETDTAKKADMDGEVYT HTPAVIQVLPQHIDMLVPANE*" /label="bmrU CDS" gene 2189867..2190760 /gene="bmrU" /locus_tag="BSU_24000" /old_locus_tag="BSU24000" /label="bmrU gene" promotor_-35 2190793..2190800 /Source="Nicolas_upshift_promotors" /id="U1877" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.97002997002997" /psig="0.993006993006993" /xcortree=1530 /SigmaFactorBS="tcataaggctttagaaagattttgcaaatCCGTTGACtctcc cctaggaggaGGTCTTACAGTATAAGGGATacacacttgaaaaaggggaagtcatatg g" /listShort="bmr, bmrR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2190816..2190835 /Source="Nicolas_upshift_promotors" /id="U1877" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.97002997002997" /psig="0.993006993006993" /xcortree=1530 /SigmaFactorBS="tcataaggctttagaaagattttgcaaatCCGTTGACtctcc cctaggaggaGGTCTTACAGTATAAGGGATacacacttgaaaaaggggaagtcatatg g" /listShort="bmr, bmrR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2190824 /Source="Nicolas_upshifts" /id="U1877" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.97002997002997" /psig="0.993006993006993" /xcortree=1530 /SigmaFactorBS="tcataaggctttagaaagattttgcaaatCCGTTGACtctcc cctaggaggaGGTCTTACAGTATAAGGGATacacacttgaaaaaggggaagtcatatg g" /listShort="bmr, bmrR" /GFF_Attribute="listLong" /label="upshifts" CDS 2190861..2192030 /gene="bmr" /locus_tag="BSU_24010" /old_locus_tag="BSU24010" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10200972, 10961951, 11321573, 15849754, 16850406, 25756668" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10200972, 10961951, 11321573, 15849754, 16850406, 25756668; Product type t : transporter" /codon_start=1 /transl_table=11 /product="multidrug-efflux transporter" /protein_id="NP_390281.2" /db_xref="EnsemblGenomes-Gn:BSU24010" /db_xref="EnsemblGenomes-Tr:CAB14332" /db_xref="GOA:P33449" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10303" /db_xref="UniProtKB/Swiss-Prot:P33449" /translation="MEKKNITLTILLTNLFIAFLGIGLVIPVTPTIMNELHLSGTAVG YMVACFAITQLIVSPIAGRWVDRFGRKIMIVIGLLFFSVSEFLFGIGKTVEMLFISRM LGGISAAFIMPGVTAFIADITTIKTRPKALGYMSAAISTGFIIGPGIGGFLAEVHSRL PFFFAAAFALLAAILSILTLREPERNPENQEIKGQKTGFKRIFAPMYFIAFLIILISS FGLASFESLFALFVDHKFGFTASDIAIMITGGAIVGAITQVVLFDRFTRWFGEIHLIR YSLILSTSLVFLLTTVHSYVAILLVTVTVFVGFDLMRPAVTTYLSKIAGNEQGFAGGM NSMFTSIGNVFGPIIGGMLFDIDVNYPFYFATVTLAIGIALTIAWKAPAHLKAST*" /label="bmr CDS" gene 2190861..2192030 /gene="bmr" /locus_tag="BSU_24010" /old_locus_tag="BSU24010" /label="bmr gene" downshifts 2192013 /Source="Nicolas_upshifts" /id="D1256" /incds=0 /nref=6 /ntot=31 /MaxReadThrough="4.82186" /MaxDrop="5.02667" /score="-1.94257488" /energy="-18" /TU="U1876,U1877" /idTUdmin="U1876" /TUdmin="-924" /isTUend="FALSE" /label="downshifts" CDS 2192103..2192939 /gene="bmrR" /locus_tag="BSU_24020" /old_locus_tag="BSU24020" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11201751, 11839496, 12682015, 14985361, 18658145, 21690368" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11201751, 11839496, 12682015, 14985361, 18658145, 21690368; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (MerR family)" /protein_id="NP_390282.2" /db_xref="EnsemblGenomes-Gn:BSU24020" /db_xref="EnsemblGenomes-Tr:CAB14333" /db_xref="GOA:P39075" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="InterPro:IPR011256" /db_xref="InterPro:IPR029442" /db_xref="PDB:1BOW" /db_xref="PDB:1EXI" /db_xref="PDB:1EXJ" /db_xref="PDB:1R8E" /db_xref="PDB:2BOW" /db_xref="PDB:3D6Y" /db_xref="PDB:3D6Z" /db_xref="PDB:3D70" /db_xref="PDB:3D71" /db_xref="PDB:3IAO" /db_xref="PDB:3Q1M" /db_xref="PDB:3Q2Y" /db_xref="PDB:3Q3D" /db_xref="PDB:3Q5P" /db_xref="PDB:3Q5R" /db_xref="PDB:3Q5S" /db_xref="SubtiList:BG10304" /db_xref="UniProtKB/Swiss-Prot:P39075" /translation="MKESYYSIGEVSKLANVSIKALRYYDKIDLFKPAYVDPDTSYRY YTDSQLIHLDLIKSLKYIGTPLEEMKKAQDLEMEELFAFYTEQERQIREKLDFLSALE QTISLVKKRMKRQMEYPALGEVFVLDEEEIRIIQTEAEGIGPENVLNASYSKLKKFIE SADGFTNNSYGATFSFQPYTSIDEMTYRHIFTPVLTNKQISSITPDMEITTIPKGRYA CIAYNFSPEHYFLNLQKLIKYIADRQLTVVSDVYELIIPIHYSPKKQEEYRVEMKIRI AE*" /label="bmrR CDS" gene 2192103..2192939 /gene="bmrR" /locus_tag="BSU_24020" /old_locus_tag="BSU24020" /label="bmrR gene" downshifts 2192937 /Source="Nicolas_upshifts" /id="D1257" /incds=0 /nref=5 /ntot=156 /MaxReadThrough="4.1979" /MaxDrop="4.72542" /score="5.00815505" /energy="-15.7" /TU="NA" /idTUdmin="U1876" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(2193001) /Source="Nicolas_upshifts" /id="D1258" /incds=0 /nref=15 /ntot=247 /MaxReadThrough="3.01431" /MaxDrop="6.04069" /score="8.5296919" /energy="-16.8" /TU="U1879" /idTUdmin="U1878" /TUdmin="-10" /isTUend="TRUE" /label="downshifts" CDS complement(2193001..2194275) /gene="bkdB" /locus_tag="BSU_24030" /old_locus_tag="BSU24030" /EC_number="2.3.1.168" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10094682, 12427936, 15241682, 22720735, 28371347" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094682, 12427936, 15241682, 22720735, 28371347; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="branched-chain alpha-keto acid dehydrogenase E2 subunit (lipoamide acyltransferase)" /protein_id="NP_390283.1" /db_xref="EnsemblGenomes-Gn:BSU24030" /db_xref="EnsemblGenomes-Tr:CAB14334" /db_xref="GOA:P37942" /db_xref="InterPro:IPR000089" /db_xref="InterPro:IPR001078" /db_xref="InterPro:IPR003016" /db_xref="InterPro:IPR004167" /db_xref="InterPro:IPR011053" /db_xref="InterPro:IPR036625" /db_xref="SubtiList:BG10305" /db_xref="UniProtKB/Swiss-Prot:P37942" /translation="MAIEQMTMPQLGESVTEGTISKWLVAPGDKVNKYDPIAEVMTDK VNAEVPSSFTGTITELVGEEGQTLQVGEMICKIETEGANPAEQKQEQPAASEAAENPV AKSAGAADQPNKKRYSPAVLRLAGEHGIDLDQVTGTGAGGRITRKDIQRLIETGGVQE QNPEELKTAAPAPKSASKPEPKEETSYPASAAGDKEIPVTGVRKAIASNMKRSKTEIP HAWTMMEVDVTNMVAYRNSIKDSFKKTEGFNLTFFAFFVKAVAQALKEFPQMNSMWAG DKIIQKKDINISIAVATEDSLFVPVIKNADEKTIKGIAKDITGLAKKVRDGKLTADDM QGGTFTVNNTGSFGSVQSMGIINYPQAAILQVESIVKRPVVMDNGMIAVRDMVNLCLS LDHRVLDGLVCGRFLGRVKQILESIDEKTSVY*" /label="bkdB CDS" gene complement(2193001..2194275) /gene="bkdB" /locus_tag="BSU_24030" /old_locus_tag="BSU24030" /label="bkdB gene" CDS complement(2194298..2195281) /gene="bkdAB" /locus_tag="BSU_24040" /old_locus_tag="BSU24040" /EC_number="1.2.4.4" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10094682, 12427936, 15241682, 28371347" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094682, 12427936, 15241682, 28371347; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="branched-chain alpha-keto acid dehydrogenase E1 subunit" /protein_id="NP_390284.1" /db_xref="EnsemblGenomes-Gn:BSU24040" /db_xref="EnsemblGenomes-Tr:CAB14335" /db_xref="GOA:P37941" /db_xref="InterPro:IPR005475" /db_xref="InterPro:IPR009014" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR033248" /db_xref="SubtiList:BG10306" /db_xref="UniProtKB/Swiss-Prot:P37941" /translation="MSVMSYIDAINLAMKEEMERDSRVFVLGEDVGRKGGVFKATAGL YEQFGEERVMDTPLAESAIAGVGIGAAMYGMRPIAEMQFADFIMPAVNQIISEAAKIR YRSNNDWSCPIVVRAPYGGGVHGALYHSQSVEAIFANQPGLKIVMPSTPYDAKGLLKA AVRDEDPVLFFEHKRAYRLIKGEVPADDYVLPIGKADVKREGDDITVITYGLCVHFAL QAAERLEKDGISAHVVDLRTVYPLDKEAIIEAASKTGKVLLVTEDTKEGSIMSEVAAI ISEHCLFDLDAPIKRLAGPDIPAMPYAPTMEKYFMVNPDKVEAAMRELAEF*" /label="bkdAB CDS" gene complement(2194298..2195281) /gene="bkdAB" /locus_tag="BSU_24040" /old_locus_tag="BSU24040" /label="bkdAB gene" CDS complement(2195295..2196287) /gene="bkdAA" /locus_tag="BSU_24050" /old_locus_tag="BSU24050" /EC_number="1.2.4.4" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10094682, 12427936, 15241682, 22720735, 28371347" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094682, 12427936, 15241682, 22720735, 28371347; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="branched-chain alpha-keto acid dehydrogenase E1 subunit" /protein_id="NP_390285.1" /db_xref="EnsemblGenomes-Gn:BSU24050" /db_xref="EnsemblGenomes-Tr:CAB14336" /db_xref="GOA:P37940" /db_xref="InterPro:IPR001017" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR034616" /db_xref="SubtiList:BG10307" /db_xref="UniProtKB/Swiss-Prot:P37940" /translation="MSTNRHQALGLTDQEAVDMYRTMLLARKIDERMWLLNRSGKIPF VISCQGQEAAQVGAAFALDREMDYVLPYYRDMGVVLAFGMTAKDLMMSGFAKAADPNS GGRQMPGHFGQKKNRIVTGSSPVTTQVPHAVGIALAGRMEKKDIAAFVTFGEGSSNQG DFHEGANFAAVHKLPVIFMCENNKYAISVPYDKQVACENISDRAIGYGMPGVTVNGND PLEVYQAVKEARERARRGEGPTLIETISYRLTPHSSDDDDSSYRGREEVEEAKKSDPL LTYQAYLKETGLLSDEIEQTMLDEIMAIVNEATDEAENAPYAAPESALDYVYAK*" /label="bkdAA CDS" gene complement(2195295..2196287) /gene="bkdAA" /locus_tag="BSU_24050" /old_locus_tag="BSU24050" /label="bkdAA gene" CDS complement(2196309..2197733) /gene="lpdV" /locus_tag="BSU_24060" /old_locus_tag="BSU24060" /EC_number="1.8.1.4" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10094682, 12427936, 15241682, 28371347" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094682, 12427936, 15241682, 28371347; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="branched-chain alpha-keto acid dehydrogenase E3 subunit (dihydrolipoamide dehydrogenase)" /protein_id="NP_390286.2" /db_xref="EnsemblGenomes-Gn:BSU24060" /db_xref="EnsemblGenomes-Tr:CAB14337" /db_xref="GOA:P54533" /db_xref="InterPro:IPR001100" /db_xref="InterPro:IPR004099" /db_xref="InterPro:IPR006258" /db_xref="InterPro:IPR012999" /db_xref="InterPro:IPR016156" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG11725" /db_xref="UniProtKB/Swiss-Prot:P54533" /translation="MATEYDVVILGGGTGGYVAAIRAAQLGLKTAVVEKEKLGGTCLH KGCIPSKALLRSAEVYRTAREADQFGVETAGVSLNFEKVQQRKQAVVDKLAAGVNHLM KKGKIDVYTGYGRILGPSIFSPLPGTISVERGNGEENDMLIPKQVIIATGSRPRMLPG LEVDGKSVLTSDEALQMEELPQSIIIVGGGVIGIEWASMLHDFGVKVTVIEYADRILP TEDLEISKEMESLLKKKGIQFITGAKVLPDTMTKTSDDISIQAEKDGETVTYSAEKML VSIGRQANIEGIGLENTDIVTENGMISVNESCQTKESHIYAIGDVIGGLQLAHVASHE GIIAVEHFAGLNPHPLDPTLVPKCIYSSPEAASVGLTEDEAKANGHNVKIGKFPFMAI GKALVYGESDGFVKIVADRDTDDILGVHMIGPHVTDMISEAGLAKVLDATPWEVGQTI HPHPTLSEAIGEAALAADGKAIHF*" /label="lpdV CDS" gene complement(2196309..2197733) /gene="lpdV" /locus_tag="BSU_24060" /old_locus_tag="BSU24060" /label="lpdV gene" CDS complement(2197754..2198845) /gene="buk" /locus_tag="BSU_24070" /old_locus_tag="BSU24070" /EC_number="2.7.2.-" /EC_number="2.7.2.7" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10094682, 12427936, 15241682" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094682, 12427936, 15241682; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="branched-chain fatty-acid kinase" /protein_id="NP_390287.2" /db_xref="EnsemblGenomes-Gn:BSU24070" /db_xref="EnsemblGenomes-Tr:CAB14338" /db_xref="GOA:P54532" /db_xref="InterPro:IPR000890" /db_xref="InterPro:IPR011245" /db_xref="InterPro:IPR023865" /db_xref="SubtiList:BG11724" /db_xref="UniProtKB/Swiss-Prot:P54532" /translation="MKVLHDEKRILTINPGSTSTKIGVFHNERSIFEKTLRHNIEELQ RFDRIIDQYEFRKNHILETLHEQGINISKFDAVCARGGLLRPIEGGTYVVNDEMIEDL KSGYAGQHASNLGGIIAREIADGLNIPSYIVDPVVVDEMSVLAKVSGMPEIERKSIFH ALNQKAVARKAAASLGKRYENMKMIITHMGGGITIGVHDRGRVVDVNNGLHGEGPFSP ERAGTVPAGDLVDLCFSGEYTKEEIMKKLVGTGGLLGYLGTNDAVKVEQMIQGGDEKA RFIYDAMAYQVAKEIGAASAALKGEVEAIVLTGGLAYGKSFVSAIRSYIDWISDVLVY PGENELQSLAQGALRVLQGEEQSKQYRIE*" /label="buk CDS" gene complement(2197754..2198845) /gene="buk" /locus_tag="BSU_24070" /old_locus_tag="BSU24070" /label="buk gene" CDS complement(2198864..2199958) /gene="bcd" /locus_tag="BSU_24080" /old_locus_tag="BSU24080" /EC_number="1.4.1.8" /EC_number="1.4.1.-" /EC_number="1.4.1.9" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:4204435, 10094682, 12427936, 15241682, 20935095, 21856856, 22720735, 28165735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4204435, 10094682, 12427936, 15241682, 20935095, 21856856, 22720735, 28165735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="branched-chain amino acid dehydrogenase" /protein_id="NP_390288.1" /db_xref="EnsemblGenomes-Gn:BSU24080" /db_xref="EnsemblGenomes-Tr:CAB14339" /db_xref="GOA:P54531" /db_xref="InterPro:IPR006095" /db_xref="InterPro:IPR006096" /db_xref="InterPro:IPR006097" /db_xref="InterPro:IPR016211" /db_xref="InterPro:IPR033524" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11723" /db_xref="UniProtKB/Swiss-Prot:P54531" /translation="MELFKYMEKYDYEQLVFCQDEQSGLKAIIAIHDTTLGPALGGTR MWTYENEEAAIEDALRLARGMTYKNAAAGLNLGGGKTVIIGDPRKDKNEEMFRAFGRY IQGLNGRYITAEDVGTTVEDMDIIHDETDYVTGISPAFGSSGNPSPVTAYGVYRGMKA AAKAAFGTDSLEGKTIAVQGVGNVAYNLCRHLHEEGANLIVTDINKQSVQRAVEDFGA RAVDPDDIYSQDCDIYAPCALGATINDDTIKQLKAKVIAGAANNQLKETRHGDQIHEM GIVYAPDYVINAGGVINVADELYGYNAERALKKVEGIYGNIERVLEISQRDGIPAYLA ADRLAEERIERMRRSRSQFLQNGHSVLSRR*" /label="bcd CDS" gene complement(2198864..2199958) /gene="bcd" /locus_tag="BSU_24080" /old_locus_tag="BSU24080" /label="bcd gene" CDS complement(2199970..2200869) /gene="ptb" /locus_tag="BSU_24090" /old_locus_tag="BSU24090" /EC_number="2.3.1.19" /EC_number="2.3.1.-" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10094682, 12427936, 15241682, 22720735, 28165735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094682, 12427936, 15241682, 22720735, 28165735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphate BCFA and butyryl coenzyme A transferase" /protein_id="NP_390289.2" /db_xref="EnsemblGenomes-Gn:BSU24090" /db_xref="EnsemblGenomes-Tr:CAB14340" /db_xref="GOA:P54530" /db_xref="InterPro:IPR002505" /db_xref="InterPro:IPR012147" /db_xref="InterPro:IPR014079" /db_xref="SubtiList:BG11722" /db_xref="UniProtKB/Swiss-Prot:P54530" /translation="MKLKDLIGKASIHKNKTIAVAHAEDEEVIRAVKLAAEHLSARFL LTGDSKKLNELTSSMQGHQVEIVHANTPEESAKLAVRAVHHKTADVLMKGNVPTSVLL KAVLNRQEGLRSASVLSHVAVFDIPDFDRLMFVTDSAMNIAPSLEELRQILQNAVHVA HAVGNNMPKAAALAAVETVNPKMEATVNAAALAQMYKRGQIKGCIVDGPLALDNAVSQ IAAAQKKISGDVAGNADILLVPTIEAGNILYKSLIYFAKASVAAVITGAKAPIALTSR ADSAENKLYSIALAICASEEYTH*" /label="ptb CDS" gene complement(2199970..2200869) /gene="ptb" /locus_tag="BSU_24090" /old_locus_tag="BSU24090" /label="ptb gene" misc_feature complement(2200905..2200924) /Source="Nicolas_upshift_promotors" /id="U1878" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.764235764235764" /psig="0.764235764235764" /xcortree=340 /SigmaFactorBS="tgcacgaatgtttcggtatacctggtatgacagcacccttaa gagcTGGCATGGAACTTGCATAATaaaaggcggagtcgaaacaagaaaggtggtaaca g" /listShort="ptb, bcd, buk, lpdV, bkdAA, bkdAB, bkdB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2200910) /Source="Nicolas_upshifts" /id="U1878" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.764235764235764" /psig="0.764235764235764" /xcortree=340 /SigmaFactorBS="tgcacgaatgtttcggtatacctggtatgacagcacccttaa gagcTGGCATGGAACTTGCATAATaaaaggcggagtcgaaacaagaaaggtggtaaca g" /listShort="ptb, bcd, buk, lpdV, bkdAA, bkdAB, bkdB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2200912..2200993) /Source="Nicolas_S_feature" /locus_tag="new_2504707_2504788_c" /HighExp="Cold, LBGtran, G180, Lbexp, G135, G150, LBGexp, Diami, Oxctl, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S910" CDS complement(2200994..2203072) /gene="bkdR" /locus_tag="BSU_24100" /old_locus_tag="BSU24100" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10094682, 12427936, 15241682, 16585774" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094682, 12427936, 15241682, 16585774; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator" /protein_id="NP_390290.1" /db_xref="EnsemblGenomes-Gn:BSU24100" /db_xref="EnsemblGenomes-Tr:CAB14341" /db_xref="GOA:P54529" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR002078" /db_xref="InterPro:IPR002197" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR013767" /db_xref="InterPro:IPR025662" /db_xref="InterPro:IPR025943" /db_xref="InterPro:IPR025944" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11721" /db_xref="UniProtKB/Swiss-Prot:P54529" /translation="MQKVLIVGAGKRGTALLHILIKTAIIDIIAVVDKDPEAPGLKEA EQYGIAVSSDWKPYIQQKPDIVIHTTGDQAVFDELLQRKHEDTIVMPGKMAYIVFQLM EEKQHLIQMLKEQTYKYDRIFNSTHDGMIFIDINEEIILFNHMAEKMVGKKREEVIGR PIKEVIPSTKMPRILKTRVPEYNQKQLLGDHLQIVTTRLPIIDEGGRLLGALCVFKDI TDAVELAEEVTNLKQVRTMLEAIIQSSDEAISVVDENGIGLLINKAYTKMTGLSEKEV IGKPANTDISEGESMHLKVLETRRPVRGVRMKVGPNEKEVIVNVAPVIVDGILKGSVG VIHDVSEIKMLTAELNRARQIIRTLEAKYTFDDIIGKSEQMLVALEQAKLGAKTPATI LLRGESGTGKELFAHAIHNESDRKYNKFIRVNCAALSENLLESELFGYEDGAFSGAKR GGKKGLFEEANNGSIFLDEIGELTQNMQAKLLRVLQEKEIVRVGGTKAIPVNVRVIAA TNVNIEKAMADGTFREDLYYRINRYPISIPPLRQRLEDIEALSVRLIQKINRDYGRNV KGLSQQALRALSAYHWPGNVRELENVLGRAMIFLNPHMEWIEKDHLPVFELEQKENDT DQGTGFDFPDIEGEKLSVAVEKFEAHLIQQTLEKHHFNRTKTAKALGVSIRNLYYKMD KYGLANEGMQ*" /label="bkdR CDS" gene complement(2200994..2203072) /gene="bkdR" /locus_tag="BSU_24100" /old_locus_tag="BSU24100" /label="bkdR gene" promotor_-10 complement(2203132..2203151) /Source="Nicolas_upshift_promotors" /id="U1879" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=2683 /SigmaFactorBS="ttatcttttcatttcctttattgtccagcggaaaaaatATTT tgtcaagagaagaaaaCGTGGTAACATAGGGTTGTGcaaattattgcaacggaataaa t" /listShort="bkdR, S910, ptb, bcd, buk, lpdV, bkdAA, bkdAB, bkdB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2203149) /Source="Nicolas_upshifts" /id="U1879" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=2683 /SigmaFactorBS="ttatcttttcatttcctttattgtccagcggaaaaaatATTT tgtcaagagaagaaaaCGTGGTAACATAGGGTTGTGcaaattattgcaacggaataaa t" /listShort="bkdR, S910, ptb, bcd, buk, lpdV, bkdAA, bkdAB, bkdB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2203159..2203166 /Source="Nicolas_upshift_promotors" /id="U1880" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.63036963036963" /psig="0.998001998001998" /xcortree=386 /SigmaFactorBS="atttgcacaaccctatgttaccacgttttcttCTCTTGACaa aatattttttcCGCTGGACAATAAAGGAAATgaaaagataaaggggttttctgaagat g" /listShort="yqzF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(2203168..2203171) /Source="Nicolas_upshift_promotors" /id="U1879" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=2683 /SigmaFactorBS="ttatcttttcatttcctttattgtccagcggaaaaaatATTT tgtcaagagaagaaaaCGTGGTAACATAGGGTTGTGcaaattattgcaacggaataaa t" /listShort="bkdR, S910, ptb, bcd, buk, lpdV, bkdAA, bkdAB, bkdB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2203180..2203199 /Source="Nicolas_upshift_promotors" /id="U1880" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.63036963036963" /psig="0.998001998001998" /xcortree=386 /SigmaFactorBS="atttgcacaaccctatgttaccacgttttcttCTCTTGACaa aatattttttcCGCTGGACAATAAAGGAAATgaaaagataaaggggttttctgaagat g" /listShort="yqzF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2203187 /Source="Nicolas_upshifts" /id="U1880" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.63036963036963" /psig="0.998001998001998" /xcortree=386 /SigmaFactorBS="atttgcacaaccctatgttaccacgttttcttCTCTTGACaa aatattttttcCGCTGGACAATAAAGGAAATgaaaagataaaggggttttctgaagat g" /listShort="yqzF" /GFF_Attribute="listLong" /label="upshifts" CDS 2203225..2203461 /gene="yqzF" /locus_tag="BSU_24110" /old_locus_tag="BSU24110" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390291.1" /db_xref="EnsemblGenomes-Gn:BSU24110" /db_xref="EnsemblGenomes-Tr:CAB14342" /db_xref="GOA:O32015" /db_xref="InterPro:IPR020138" /db_xref="SubtiList:BG13772" /db_xref="UniProtKB/Swiss-Prot:O32015" /translation="MSRLLALLILVIPGAISALGIKLMRDTLFGHTIKPFSALWLQGL SGFIFFAIGLYVLAGFILYRDRKRNQVSPRFRKR*" /label="yqzF CDS" gene 2203225..2203461 /gene="yqzF" /locus_tag="BSU_24110" /old_locus_tag="BSU24110" /label="yqzF gene" downshifts 2203452 /Source="Nicolas_upshifts" /id="D1259" /incds=0 /nref=64 /ntot=230 /MaxReadThrough="2.80342" /MaxDrop="5.10794" /score="42.7247617" /energy="-11.9" /TU="NA" /idTUdmin="U1880" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2203503..2204408) /gene="mmgF" /locus_tag="BSU_24120" /old_locus_tag="BSU24120" /EC_number="4.1.3.30" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12706720, 17274076, 28956599" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12706720, 17274076, 28956599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-methylisocitrate lyase" /protein_id="NP_390292.1" /db_xref="EnsemblGenomes-Gn:BSU24120" /db_xref="EnsemblGenomes-Tr:CAB14343" /db_xref="GOA:P54528" /db_xref="InterPro:IPR012695" /db_xref="InterPro:IPR015813" /db_xref="InterPro:IPR018523" /db_xref="SubtiList:BG11720" /db_xref="UniProtKB/Swiss-Prot:P54528" /translation="MSWIVNKQSSQEELAGRFRKLMSAPDILQIPGAHDGMAALLAKE AGFSAIYLSGAAYTASRGLPDLGIITSAEIAERAKDLVRAADLPLLVDIDTGFGGVLN AARTAREMLEARVAAVQMEDQQLPKKCGHLNGKQLVPIKEMAQKIKAIKQAAPSLIVV ARTDARAQEGLDAAIKRSEAYIEAGADAIFPEALQAENEFRQFAERIPVPLLANMTEF GKTPYYRADEFEDMGFHMVIYPVTSLRAAAKACERMFGLMKEHGSQKEGLHDMQTRKE LYDTISYYDYEALDKTIAKTVLPDE*" /label="mmgF CDS" gene complement(2203503..2204408) /gene="mmgF" /locus_tag="BSU_24120" /old_locus_tag="BSU24120" /label="mmgF gene" downshifts complement(2203506) /Source="Nicolas_upshifts" /id="D1260" /incds=0 /nref=29 /ntot=69 /MaxReadThrough="2.12559" /MaxDrop="5.62" /score="33.814061" /energy="-11.9" /TU="NA" /idTUdmin="U1884" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2204426..2205844) /gene="mmgE" /locus_tag="BSU_24130" /old_locus_tag="BSU24130" /EC_number="4.2.1.79" /EC_number="4.2.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17274076, 28956599" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17274076, 28956599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-methylcitrate dehydratase (promiscuous)" /protein_id="NP_390293.2" /db_xref="EnsemblGenomes-Gn:BSU24130" /db_xref="EnsemblGenomes-Tr:CAB14344" /db_xref="GOA:P45859" /db_xref="InterPro:IPR005656" /db_xref="InterPro:IPR012705" /db_xref="InterPro:IPR036148" /db_xref="SubtiList:BG11323" /db_xref="UniProtKB/Swiss-Prot:P45859" /translation="MPKTDRVIEEITDYVLEKEITSAEAYTTAGHVLLDTLGCGILAL RYPECTKLLGPIVPGTTVPNGSKVPGTSYVLDPVRAAFNIGCMIRWLDYNDTWLAAEW GHPSDNLGGILAAADYVSRVRLSEGKEPLTVRDVLEMMIKAHEIQGVLALENSLNRVG LDHVLFVKVATTAVAAKLLGGGREEIKNALSNAWIDNAALRTYRHSPNTGSRKSWAAG DATSRGVHLALMSLKGEMGYPTALSAPGWGFQDVLFNKKEIKLARPLDAYVMENVLFK VSYPAEFHAQTAAESAVILHPQVKNRIDEIDRVVIRTHESAIRIIDKKGPLHNPADRD HCLQYITAIGLLFGDITAQHYEAETANDPRIDKLRDKMEVTENKTYTEDYLKPDKRSI SNAVQVHFKDGTSTEMVECEFPLGHRFRREEAVPKLLEKFSDNLKTHFPDKQHKHIYE RCTSYETLQTMRVNEFVDMFCM*" /label="mmgE CDS" gene complement(2204426..2205844) /gene="mmgE" /locus_tag="BSU_24130" /old_locus_tag="BSU24130" /label="mmgE gene" misc_feature complement(2204721..2204740) /Source="Nicolas_upshift_promotors" /id="U1881" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.881118881118881" /psig="0.997002997002997" /xcortree=616 /SigmaFactorBS="tatcaccgcacagcattatgaagctgaaacagcgaatgatcc gagaatagataaacttCGTGATAAAATGGAAGTGACtgaaaataaaacatataccgag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2204738) /Source="Nicolas_upshifts" /id="U1881" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.881118881118881" /psig="0.997002997002997" /xcortree=616 /SigmaFactorBS="tatcaccgcacagcattatgaagctgaaacagcgaatgatcc gagaatagataaacttCGTGATAAAATGGAAGTGACtgaaaataaaacatataccgag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2205859..2206977) /gene="mmgD" /locus_tag="BSU_24140" /old_locus_tag="BSU24140" /EC_number="2.3.3.5" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8759838, 17274076, 28956599" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8759838, 17274076, 28956599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional citrate synthase/2-methylcitrate synthase" /protein_id="NP_390294.1" /db_xref="EnsemblGenomes-Gn:BSU24140" /db_xref="EnsemblGenomes-Tr:CAB14345" /db_xref="GOA:P45858" /db_xref="InterPro:IPR002020" /db_xref="InterPro:IPR016142" /db_xref="InterPro:IPR019810" /db_xref="InterPro:IPR024176" /db_xref="InterPro:IPR036969" /db_xref="SubtiList:BG11322" /db_xref="UniProtKB/Swiss-Prot:P45858" /translation="MEEKQHYSPGLDGVIAAETHISYLDTQSSQILIRGYDLIELSET KSYLELVHLLLEGRLPEESEMETLERKINSASSLPADHLRLLELLPEDTHPMDGLRTG LSALAGYDRQIDDRSPSANKERAYQLLGKMPALTAASYRIINKKEPILPLQTLSYSAN FLYMMTGKLPSSLEEQIFDRSLVLYSEHEMPNSTFAARVIASTHSDLYGALTGAVASL KGNLHGGANEAVMYLLLEAKTTSDFEQLLQTKLKRKEKIMGFGHRVYMKKMDPRALMM KEALQQLCDKAGDHRLYEMCEAGERLMEKEKGLYPNLDYYAAPVYWMLGIPIPLYTPI FFSARTSGLCAHVIEQHANNRLFRPRVSYMGPRYQTKS*" /label="mmgD CDS" gene complement(2205859..2206977) /gene="mmgD" /locus_tag="BSU_24140" /old_locus_tag="BSU24140" /label="mmgD gene" CDS complement(2207011..2208150) /gene="mmgC" /locus_tag="BSU_24150" /old_locus_tag="BSU24150" /EC_number="1.3.99.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:28956599" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 28956599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="propionyl-CoA dehydrogenase subunit" /protein_id="NP_390295.2" /db_xref="EnsemblGenomes-Gn:BSU24150" /db_xref="EnsemblGenomes-Tr:CAB14346" /db_xref="GOA:P45857" /db_xref="InterPro:IPR006089" /db_xref="InterPro:IPR006091" /db_xref="InterPro:IPR009075" /db_xref="InterPro:IPR009100" /db_xref="InterPro:IPR013786" /db_xref="InterPro:IPR036250" /db_xref="InterPro:IPR037069" /db_xref="PDB:5LNX" /db_xref="SubtiList:BG11321" /db_xref="UniProtKB/Swiss-Prot:P45857" /translation="MHVTQEQVMMRKMVRDFARKEIAPAAEIMEKTDEFPFQLIKKMG KHGLMGIPVPEQYGGAGADVVSYILAIHEISRISAAVGVILSVHTSVGTNPILYFGNE EQKMKYIPNLASGDHLGAFALTEPHSGSDAGSLRTTAIKKNGKYLLNGSKIFITNGGA ADIYITFALTAPDQGRHGISAFIVEKNTPGFTVGKKERKLGLYGSNTTELIFDNAEVP EANLLGKEGDGFHIAMANLNVGRIGIAAQALGIAEAALEHAVDYAKQRVQFGRPIAAN QGISFKLADMATRAEAARHLVYHAADLHNRGLNCGKEASMAKQFASDAAVKAALDAVQ IYGGYGYMKDYPVERLLRDAKVTQIYEGTNEIQRLIISKYLLGGT*" /label="mmgC CDS" gene complement(2207011..2208150) /gene="mmgC" /locus_tag="BSU_24150" /old_locus_tag="BSU24150" /label="mmgC gene" CDS complement(2208178..2209041) /gene="mmgB" /locus_tag="BSU_24160" /old_locus_tag="BSU24160" /EC_number="1.1.1.157" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8759838, 18461320, 28956599" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8759838, 18461320, 28956599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-hydroxybutyryl-CoA dehydrogenase" /protein_id="NP_390296.2" /db_xref="EnsemblGenomes-Gn:BSU24160" /db_xref="EnsemblGenomes-Tr:CAB14347" /db_xref="GOA:P45856" /db_xref="InterPro:IPR006108" /db_xref="InterPro:IPR006176" /db_xref="InterPro:IPR006180" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR022694" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11320" /db_xref="UniProtKB/Swiss-Prot:P45856" /translation="MEIKQIMVAGAGQMGSGIAQTAADAGFYVRMYDVNPEAAEAGLK RLKKQLARDAEKGKRTETEVKSVINRISISQTLEEAEHADIVIEAIAENMAAKTEMFK TLDRICPPHTILASNTSSLPITEIAAVTNRPQRVIGMHFMNPVPVMKLVEVIRGLATS EETALDVMALAEKMGKTAVEVNDFPGFVSNRVLLPMINEAIYCVYEGVAKPEAIDEVM KLGMNHPMGPLALADFIGLDTCLSIMEVLHSGLGDSKYRPCPLLRKYVKAGWLGKKSG RGFYDYEEKTS*" /label="mmgB CDS" gene complement(2208178..2209041) /gene="mmgB" /locus_tag="BSU_24160" /old_locus_tag="BSU24160" /label="mmgB gene" CDS complement(2209066..2210247) /gene="mmgA" /locus_tag="BSU_24170" /old_locus_tag="BSU24170" /EC_number="2.3.1.9" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16352833, 18246303, 19016856, 28956599" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16352833, 18246303, 19016856, 28956599; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="degradative acetoacetyl-CoA thiolase" /protein_id="NP_390297.1" /db_xref="EnsemblGenomes-Gn:BSU24170" /db_xref="EnsemblGenomes-Tr:CAB14348" /db_xref="GOA:P45855" /db_xref="InterPro:IPR002155" /db_xref="InterPro:IPR016039" /db_xref="InterPro:IPR020610" /db_xref="InterPro:IPR020613" /db_xref="InterPro:IPR020615" /db_xref="InterPro:IPR020616" /db_xref="InterPro:IPR020617" /db_xref="PDB:5LP7" /db_xref="SubtiList:BG11319" /db_xref="UniProtKB/Swiss-Prot:P45855" /translation="MRKTVIVSAARTPFGKFGGVLKEVKAAELGGIVMKEALQQAGVS GDDVEGNVMGMVVQAGSGQIPSRQAARLAGMPWSVPSETLNKVCASGLRAVTLCDQMI RAQDADILVAGGMESMSNIPYAVPAGRWGARMGDGELRDLMVYDGLTCAFDEVHMAVH GNTAAKEYAISRREQDEWALRSHARAAKAADEGKFQDEIVPVNWIGRKGKPNVVDKDE AIRRDTSLDQLAKLAPIYASDGSITAGNAPGVNDGAGAFVLMSEEKAAELGKRPLATI LGFSTTGMPAHELAAAPGFAINKLLKKNGLTVQDIDLFEVNEAFASVVLTCEKIVGFD LEKVNVNGGAIALGHPIGASGARILMTLVYELKRRGGGLGVAAICSGAAQGDAVLVQV H*" /label="mmgA CDS" gene complement(2209066..2210247) /gene="mmgA" /locus_tag="BSU_24170" /old_locus_tag="BSU24170" /label="mmgA gene" downshifts complement(2209827) /Source="Nicolas_upshifts" /id="D1261" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="6.17207" /MaxDrop="2.33167" /score="-0.949614429" /energy="-7.8" /TU="U1884" /idTUdmin="U1885" /TUdmin=550 /isTUend="FALSE" /label="downshifts" misc_feature complement(2209934..2209940) /Source="Nicolas_upshift_promotors" /id="U1882" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.382617382617383" /psig="0.0869130869130869" /xcortree=1497 /SigmaFactorBS="tgaataaagtctgtgcttccggccttcgcgctgtcactttat gtgatcaaatgattcGGGCGCAggatgcggacatacttgttgcgggggggatggaaag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2209937) /Source="Nicolas_upshifts" /id="U1882" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.382617382617383" /psig="0.0869130869130869" /xcortree=1497 /SigmaFactorBS="tgaataaagtctgtgcttccggccttcgcgctgtcactttat gtgatcaaatgattcGGGCGCAggatgcggacatacttgttgcgggggggatggaaag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_no_box complement(2210161..2210261) /Source="Nicolas_upshift_promotors" /id="U1883" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.495504495504495" /psig="0.002997002997003" /xcortree=1483 /SigmaFactorBS="aatgaggtgaaaccatgaggaaaacagtcattgtaagtgctg caagaactccatttggcaaattcggcggagttttgaaagaggtgaaagctgctgagct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(2210201) /Source="Nicolas_upshifts" /id="U1883" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.495504495504495" /psig="0.002997002997003" /xcortree=1483 /SigmaFactorBS="aatgaggtgaaaccatgaggaaaacagtcattgtaagtgctg caagaactccatttggcaaattcggcggagttttgaaagaggtgaaagctgctgagct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2210294..2210312) /Source="Nicolas_upshift_promotors" /id="U1884" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1050 /SigmaFactorBS="tgttagaaggaggctgtttgacgcagccttcttttttcaTTC ATTcatgcccgtttcaaaGCATACATTCATAGAAGACaactagaaattgtaagcgctg t" /listShort="mmgA, mmgB, mmgC, prpC, prpD, prpB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2210312) /Source="Nicolas_upshifts" /id="U1884" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1050 /SigmaFactorBS="tgttagaaggaggctgtttgacgcagccttcttttttcaTTC ATTcatgcccgtttcaaaGCATACATTCATAGAAGACaactagaaattgtaagcgctg t" /listShort="mmgA, mmgB, mmgC, prpC, prpD, prpB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2210328..2210333) /Source="Nicolas_upshift_promotors" /id="U1884" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1050 /SigmaFactorBS="tgttagaaggaggctgtttgacgcagccttcttttttcaTTC ATTcatgcccgtttcaaaGCATACATTCATAGAAGACaactagaaattgtaagcgctg t" /listShort="mmgA, mmgB, mmgC, prpC, prpD, prpB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2210374..2211105) /gene="glpQ" /locus_tag="BSU_24180" /old_locus_tag="BSU24180" /EC_number="3.1.4.46" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6319195, 14563871, 21966272, 22843846, 24373430, 27780866" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6319195, 14563871, 21966272, 22843846, 24373430, 27780866; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="glycerophosphodiester phosphodiesterase (exolytic cleavage of individual teichoic acid monomer units)" /protein_id="NP_390298.2" /db_xref="EnsemblGenomes-Gn:BSU24180" /db_xref="EnsemblGenomes-Tr:CAB14349" /db_xref="GOA:P54527" /db_xref="InterPro:IPR004129" /db_xref="InterPro:IPR017946" /db_xref="InterPro:IPR030395" /db_xref="SubtiList:BG11719" /db_xref="UniProtKB/Swiss-Prot:P54527" /translation="MTKIFAHRGASGQFPENTMLAFEKGIEAGADGIELDVQLTKDGR IVVIHDERLNRTTSLKGFVKDTAYDEVKTANAAAGHDQAYSDIKVPLLEDVLSWAVKK DFLINIELKNSVIRYEGMEEKVLEAVKRFNVEDRVILSTFNHDSLALCARLAPHIERA VLTSDVLYQADRYIASIPASGYHPKINSPGVTDEVLKKMRNGLIKVRPYTVNRPEDMK RLIEAGADGMFTDFPEKASALLKNE*" /label="glpQ CDS" gene complement(2210374..2211105) /gene="glpQ" /locus_tag="BSU_24180" /old_locus_tag="BSU24180" /label="glpQ gene" downshifts complement(2210381) /Source="Nicolas_upshifts" /id="D1262" /incds=0 /nref=31 /ntot=180 /MaxReadThrough="0.31166" /MaxDrop="4.10202" /score="-0.949614429" /energy="-7.8" /TU="NA" /idTUdmin="U1885" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2211128..2211147) /Source="Nicolas_upshift_promotors" /id="U1885" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.838161838161838" /psig="0.999000999001" /xcortree=1960 /SigmaFactorBS="ttattatgatcagtagattgatacagccttaatcCTAGagtg gagccgacaaAATAAGTATAATGGAGAAAActttagggtttgaggtgaaacgatgaca a" /listShort="yqiK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2211139) /Source="Nicolas_upshifts" /id="U1885" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.838161838161838" /psig="0.999000999001" /xcortree=1960 /SigmaFactorBS="ttattatgatcagtagattgatacagccttaatcCTAGagtg gagccgacaaAATAAGTATAATGGAGAAAActttagggtttgaggtgaaacgatgaca a" /listShort="yqiK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2211162..2211165) /Source="Nicolas_upshift_promotors" /id="U1885" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.838161838161838" /psig="0.999000999001" /xcortree=1960 /SigmaFactorBS="ttattatgatcagtagattgatacagccttaatcCTAGagtg gagccgacaaAATAAGTATAATGGAGAAAActttagggtttgaggtgaaacgatgaca a" /listShort="yqiK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2211184..2211804) /gene="yqiI" /locus_tag="BSU_24190" /old_locus_tag="BSU24190" /EC_number="3.5.1.28" /experiment="publication(s) with functional evidences, PMID:22843846" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22843846; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylmuramoyl-L-alanine amidase" /protein_id="NP_390299.2" /db_xref="EnsemblGenomes-Gn:BSU24190" /db_xref="EnsemblGenomes-Tr:CAB14350" /db_xref="GOA:P54525" /db_xref="InterPro:IPR002508" /db_xref="SubtiList:BG11717" /db_xref="UniProtKB/Swiss-Prot:P54525" /translation="MRMLWRSLALCGLALTLAPCAQAAEPIEGKTVYIDAGHGGEDSG AVGNGLFEKDINLAVSEHVTDKLKEEGANPVASRSDDHFLTLEERVAKASANQADLFV SIHVNSGVASASGTETYFQSDYEGENSRRLASDIQSQLVSSLQTRDRGVKESDFYVIT YSQMPSVLAELGFITNSSDADKLGSEEYQQKAADAIVNGIDSYYDQ*" /label="yqiI CDS" gene complement(2211184..2211804) /gene="yqiI" /locus_tag="BSU_24190" /old_locus_tag="BSU24190" /label="yqiI gene" CDS complement(2211819..2212112) /gene="yqiH" /locus_tag="BSU_24200" /old_locus_tag="BSU24200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22843846; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_390300.2" /db_xref="EnsemblGenomes-Gn:BSU24200" /db_xref="EnsemblGenomes-Tr:CAB14351" /db_xref="GOA:P40770" /db_xref="SubtiList:BG11030" /db_xref="UniProtKB/Swiss-Prot:P40770" /translation="MKQTVLLLFTALFLSGCSVASADDSVPRFTEEGKYIGSADPHTI AVSLNGEETMIQVPKDKRDECESLPDQTHVLVKYTKKDNGTLQLEDIQLRKNS*" /label="yqiH CDS" gene complement(2211819..2212112) /gene="yqiH" /locus_tag="BSU_24200" /old_locus_tag="BSU24200" /label="yqiH gene" promotor_-10 complement(2212132..2212151) /Source="Nicolas_upshift_promotors" /id="U1886" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.909090909090909" /psig="0.978021978021978" /xcortree=2990 /SigmaFactorBS="aacttgctcgcctgcattcgcgttgTCTTTACAaattctcca ttctgGTCAAAGATAAAAGCCAAACatcaggaagaggtggtcatgtgaaacaaacggt t" /listShort="yqiH, yqiI, yqiK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2212138) /Source="Nicolas_upshifts" /id="U1886" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.909090909090909" /psig="0.978021978021978" /xcortree=2990 /SigmaFactorBS="aacttgctcgcctgcattcgcgttgTCTTTACAaattctcca ttctgGTCAAAGATAAAAGCCAAACatcaggaagaggtggtcatgtgaaacaaacggt t" /listShort="yqiH, yqiI, yqiK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2212166..2212173) /Source="Nicolas_upshift_promotors" /id="U1886" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.909090909090909" /psig="0.978021978021978" /xcortree=2990 /SigmaFactorBS="aacttgctcgcctgcattcgcgttgTCTTTACAaattctcca ttctgGTCAAAGATAAAAGCCAAACatcaggaagaggtggtcatgtgaaacaaacggt t" /listShort="yqiH, yqiI, yqiK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2212368..2212375 /Source="Nicolas_upshift_promotors" /id="U1887" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.973026973026973" /psig="0.996003996003996" /xcortree=1968 /SigmaFactorBS="tttgagaatagggtgagcaaatCGTTTGACgggtgggtcagc cAAGCGTAACCTTTTAAAGGAtatttactttattgaaagaagttaaagccatgaaaaa a" /listShort="S911, yqiG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2212389..2212408 /Source="Nicolas_upshift_promotors" /id="U1887" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.973026973026973" /psig="0.996003996003996" /xcortree=1968 /SigmaFactorBS="tttgagaatagggtgagcaaatCGTTTGACgggtgggtcagc cAAGCGTAACCTTTTAAAGGAtatttactttattgaaagaagttaaagccatgaaaaa a" /listShort="S911, yqiG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2212406..2212611 /Source="Nicolas_S_feature" /locus_tag="new_2516201_2516406" /HighExp="Diami, dia15, dia5, H2O2, Paraq, LBGexp, G180, LBGstat, LBGtran, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99653599999999998" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S911" upshifts 2212406 /Source="Nicolas_upshifts" /id="U1887" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.973026973026973" /psig="0.996003996003996" /xcortree=1968 /SigmaFactorBS="tttgagaatagggtgagcaaatCGTTTGACgggtgggtcagc cAAGCGTAACCTTTTAAAGGAtatttactttattgaaagaagttaaagccatgaaaaa a" /listShort="S911, yqiG" /GFF_Attribute="listLong" /label="upshifts" CDS 2212420..2212572 /locus_tag="BSU_24205" /old_locus_tag="BSU24205" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513977.1" /translation="MKEVKAMKKFVLLLAAAVITCSIGHQISGGYKGPEKERPKHHSA LKIFSR*" /label="hypothetical protein CDS" gene 2212420..2212572 /locus_tag="BSU_24205" /old_locus_tag="BSU24205" /label="gene" promotor_-35 2212580..2212587 /Source="Nicolas_upshift_promotors" /id="U1888" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.83016983016983" /psig="0.993006993006993" /xcortree=612 /SigmaFactorBS="tcaagatattcagtcggtaaagcagatCAATTGCAttaattt ttacataTAGGCTAGAATATGTGCGAAtccaaacgaaagaagatgatcaaatgaatcc t" /listShort="yqiG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2212602..2212621 /Source="Nicolas_upshift_promotors" /id="U1888" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.83016983016983" /psig="0.993006993006993" /xcortree=612 /SigmaFactorBS="tcaagatattcagtcggtaaagcagatCAATTGCAttaattt ttacataTAGGCTAGAATATGTGCGAAtccaaacgaaagaagatgatcaaatgaatcc t" /listShort="yqiG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2212613 /Source="Nicolas_upshifts" /id="U1888" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.83016983016983" /psig="0.993006993006993" /xcortree=612 /SigmaFactorBS="tcaagatattcagtcggtaaagcagatCAATTGCAttaattt ttacataTAGGCTAGAATATGTGCGAAtccaaacgaaagaagatgatcaaatgaatcc t" /listShort="yqiG" /GFF_Attribute="listLong" /label="upshifts" CDS 2212645..2213763 /gene="yqiG" /locus_tag="BSU_24210" /old_locus_tag="BSU24210" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NADH-dependent flavin oxidoreductase" /protein_id="NP_390301.1" /db_xref="EnsemblGenomes-Gn:BSU24210" /db_xref="EnsemblGenomes-Tr:CAB14352" /db_xref="GOA:P54524" /db_xref="InterPro:IPR001155" /db_xref="InterPro:IPR013785" /db_xref="SubtiList:BG11716" /db_xref="UniProtKB/Swiss-Prot:P54524" /translation="MNPKYKPLFEPFTFKSGVTINNRIAVAPMTHYASNEDGTISEAE LDYIIPRSKEMGMVITACANVTPDGKAFPGQPAIHDDSNIPGLKKLAQAIQAQGAKAV VQIHHGGIECPSELVPQQDVVGPSDVFDNGKQIARALTEEEVENIVKAFGEATRRAIE AGFDGVEIHGANGYLIQQFYSPKTNQRTDRWGGSDEKRLAFPLAIVDEVKKAASEHAK GAFLVGYRLSPEEPETPGLTMTETYTLVDALGDKELDYLHISLMDVNSKARRGADPTR TRMDLLNERVGNKVPLIAVGSIHSADDALAVIENGIPLVAMGREILVDPNWTVKVKEG REKQIETVIKGTDKEKYHLPEPLWQAIVNTQGWVPYKD*" /label="yqiG CDS" gene 2212645..2213763 /gene="yqiG" /locus_tag="BSU_24210" /old_locus_tag="BSU24210" /label="yqiG gene" downshifts 2213748 /Source="Nicolas_upshifts" /id="D1263" /incds=0 /nref=23 /ntot=181 /MaxReadThrough="1.88324" /MaxDrop="6.67511" /score="30.8551972" /energy="-16.1" /TU="NA" /idTUdmin="U1887" /TUdmin="-9" /isTUend="TRUE" /label="downshifts" S_feature complement(2213790..2213960) /Source="Nicolas_S_feature" /locus_tag="new_2517585_2517755_c" /HighExp="T0.30H, S6, S8, T1.30H, T1.0H, T-0.40H, S7, Salt, T0.0H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY, SigK" /TUshortPSig="1, 0.956" /TUlongSig="NA" /TUlongPSig="NA" /label="S912" downshifts complement(2213833) /Source="Nicolas_upshifts" /id="D1264" /incds=0 /nref=1 /ntot=37 /MaxReadThrough="3.46085" /MaxDrop="2.69939" /score="-5.47428449" /energy="-16.1" /TU="U1889" /idTUdmin="U1890" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2213944..2213959) /Source="Nicolas_upshift_promotors" /id="U1889" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1662 /SigmaFactorBS="tcacgaagcatgatcgaccctagatgtgtccgttataaaaTG AAACCTTTctcctgcaaaaTCGTAAGTAAGGCGTAttcatgtaaaaaggagacgtacg a" /listShort="S912" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2213960) /Source="Nicolas_upshifts" /id="U1889" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1662 /SigmaFactorBS="tcacgaagcatgatcgaccctagatgtgtccgttataaaaTG AAACCTTTctcctgcaaaaTCGTAAGTAAGGCGTAttcatgtaaaaaggagacgtacg a" /listShort="S912" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2213962..2214090) /Source="Nicolas_S_feature" /locus_tag="new_2517757_2517885_c" /HighExp="S6, S8, S7, S5, BT, M9-stat, B36, G180, G135, S4" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.956" /TUlongSig="NA" /TUlongPSig="NA" /label="S913" promotor_-35 complement(2213971..2213980) /Source="Nicolas_upshift_promotors" /id="U1889" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1662 /SigmaFactorBS="tcacgaagcatgatcgaccctagatgtgtccgttataaaaTG AAACCTTTctcctgcaaaaTCGTAAGTAAGGCGTAttcatgtaaaaaggagacgtacg a" /listShort="S912" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2214089..2214108) /Source="Nicolas_upshift_promotors" /id="U1890" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1313 /SigmaFactorBS="ctgataaataggaggcgttttgttttggggacatttgtagta TGGGAGAAGaatattaagtatcCGCATATAGTAAAGGATAGGtttgaaaagtaaggaa a" /listShort="S913, S912" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2214112) /Source="Nicolas_upshifts" /id="U1890" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1313 /SigmaFactorBS="ctgataaataggaggcgttttgttttggggacatttgtagta TGGGAGAAGaatattaagtatcCGCATATAGTAAAGGATAGGtttgaaaagtaaggaa a" /listShort="S913, S912" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2214122..2214130) /Source="Nicolas_upshift_promotors" /id="U1890" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.956043956043956" /psig="0.956043956043956" /xcortree=1313 /SigmaFactorBS="ctgataaataggaggcgttttgttttggggacatttgtagta TGGGAGAAGaatattaagtatcCGCATATAGTAAAGGATAGGtttgaaaagtaaggaa a" /listShort="S913, S912" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2214222) /Source="Nicolas_upshifts" /id="D1265" /incds=0 /nref=199 /ntot=267 /MaxReadThrough="2.54843" /MaxDrop="4.82417" /score="-1.10791055" /energy="-15.5" /TU="NA" /idTUdmin="U1891" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2214228..2215031) /gene="spo0A" /locus_tag="BSU_24220" /old_locus_tag="BSU24220" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8504245, 12406209, 15556029, 15808745, 23569226, 26152584, 27148245, 27501195, 28723971" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8504245, 12406209, 15556029, 15808745, 23569226, 26152584, 27148245, 27501195, 28723971; Product type r: regulator" /codon_start=1 /transl_table=11 /product="response regulator, phosphorylated in response to complex YlbF/YmcA/YaaT" /protein_id="NP_390302.1" /db_xref="EnsemblGenomes-Gn:BSU24220" /db_xref="EnsemblGenomes-Tr:CAB14353" /db_xref="GOA:P06534" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR012052" /db_xref="InterPro:IPR014879" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="PDB:1LQ1" /db_xref="SubtiList:BG10765" /db_xref="UniProtKB/Swiss-Prot:P06534" /translation="MEKIKVCVADDNRELVSLLSEYIEGQEDMEVIGVAYNGQECLSL FKEKDPDVLVLDIIMPHLDGLAVLERLRESDLKKQPNVIMLTAFGQEDVTKKAVDLGA SYFILKPFDMENLVGHIRQVSGNASSVTHRAPSSQSSIIRSSQPEPKKKNLDASITSI IHEIGVPAHIKGYLYLREAISMVYNDIELLGSITKVLYPDIAKKFNTTASRVERAIRH AIEVAWSRGNIDSISSLFGYTVSMTKAKPTNSEFIAMVADKLRLEHKAS*" /label="spo0A CDS" gene complement(2214228..2215031) /gene="spo0A" /locus_tag="BSU_24220" /old_locus_tag="BSU24220" /label="spo0A gene" promotor_-10 complement(2215074..2215092) /Source="Nicolas_upshift_promotors" /id="U1891" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=457 /SigmaFactorBS="ccactaatattggtgattatgatttttttAGAGGGTATatag cggtttTGTCGAATGTAAACATGTAgcaagggtgaatcctgttaactacatttgggga g" /listShort="spo0A" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2215080) /Source="Nicolas_upshifts" /id="U1891" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=457 /SigmaFactorBS="ccactaatattggtgattatgatttttttAGAGGGTATatag cggtttTGTCGAATGTAAACATGTAgcaagggtgaatcctgttaactacatttgggga g" /listShort="spo0A" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2215082..2215234) /Source="Nicolas_S_feature" /locus_tag="new_2518877_2519029_c" /HighExp="T1.30H, T3.0H, T2.30H, T2.0H, HiTm, Lbtran, T1.0H, T-0.40H, T0.30H, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S914" promotor_-35 complement(2215103..2215111) /Source="Nicolas_upshift_promotors" /id="U1891" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=457 /SigmaFactorBS="ccactaatattggtgattatgatttttttAGAGGGTATatag cggtttTGTCGAATGTAAACATGTAgcaagggtgaatcctgttaactacatttgggga g" /listShort="spo0A" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2215230..2215249) /Source="Nicolas_upshift_promotors" /id="U1892" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=2278 /SigmaFactorBS="cggagtttccggcagtttttttattttgatccctCTTCACTT ctcagaatacaTACGGTAAAATATACAAAAGaagatttttcgacaaattcacgtttcc t" /listShort="S914, spo0A" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2215242) /Source="Nicolas_upshifts" /id="U1892" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=2278 /SigmaFactorBS="cggagtttccggcagtttttttattttgatccctCTTCACTT ctcagaatacaTACGGTAAAATATACAAAAGaagatttttcgacaaattcacgtttcc t" /listShort="S914, spo0A" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2215261..2215268) /Source="Nicolas_upshift_promotors" /id="U1892" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=2278 /SigmaFactorBS="cggagtttccggcagtttttttattttgatccctCTTCACTT ctcagaatacaTACGGTAAAATATACAAAAGaagatttttcgacaaattcacgtttcc t" /listShort="S914, spo0A" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2215307..2216587) /gene="spoIVB" /locus_tag="BSU_24230" /old_locus_tag="BSU24230" /EC_number="3.4.-.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12218026, 15292188, 16164552, 16238631, 16818230, 17493131, 17557826" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12218026, 15292188, 16164552, 16238631, 16818230, 17493131, 17557826; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="regulatory membrane-associated serine protease" /protein_id="NP_390303.2" /db_xref="EnsemblGenomes-Gn:BSU24230" /db_xref="EnsemblGenomes-Tr:CAB14354" /db_xref="GOA:P17896" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR008763" /db_xref="InterPro:IPR009003" /db_xref="InterPro:IPR014219" /db_xref="InterPro:IPR036034" /db_xref="SubtiList:BG10311" /db_xref="UniProtKB/Swiss-Prot:P17896" /translation="MPDNIRKAVGLILLVSLLSVGLCKPLKEYLLIPTQMRVFETQTQ AIETSLSVNAQTSESSEAFTVKKDPHEIKVTGKKSGESELVYDLAGFPIKKTKVHVLP DLKVIPGGQSIGVKLHSVGVLVVGFHQINTSEGKKSPGETAGIEAGDIIIEMNGQKIE KMNDVAPFIQKAGKTGESLDLLIKRDKQKIKTKLIPEKDEGEGKYRIGLYIRDSAAGI GTMTFYEPKTKKYGALGHVISDMDTKKPIVVENGEIVKSTVTSIEKGTGGNPGEKLAR FSSERKTIGDINRNSPFGIFGTLHQPIQNNISDQALPVAFSTEVKKGPAEILTVIDDD KVEKFDIEIVSTTPQKFPATKGMVLKITDPRLLKETGGIVQGMSGSPIIQNGKVIGAV THVFVNDPTSGYGVHIEWMLSEAGIDIYGKEKAS*" /label="spoIVB CDS" gene complement(2215307..2216587) /gene="spoIVB" /locus_tag="BSU_24230" /old_locus_tag="BSU24230" /label="spoIVB gene" downshifts complement(2215322) /Source="Nicolas_upshifts" /id="D1266" /incds=0 /nref=34 /ntot=51 /MaxReadThrough="1.04939" /MaxDrop="7.80695" /score="49.1812184" /energy="-12.5" /TU="NA" /idTUdmin="U1893" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2216648..2216659) /Source="Nicolas_upshift_promotors" /id="U1893" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=830 /SigmaFactorBS="cattcgttcatcagtatatccaatgtttttcttcatatgaca GTTATAAataagccgtcagaaGGCAAAATTAAAtgatgtagcagcaagtcataaagaa g" /listShort="spoIVB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2216662) /Source="Nicolas_upshifts" /id="U1893" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=830 /SigmaFactorBS="cattcgttcatcagtatatccaatgtttttcttcatatgaca GTTATAAataagccgtcagaaGGCAAAATTAAAtgatgtagcagcaagtcataaagaa g" /listShort="spoIVB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2216674..2216680) /Source="Nicolas_upshift_promotors" /id="U1893" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=830 /SigmaFactorBS="cattcgttcatcagtatatccaatgtttttcttcatatgaca GTTATAAataagccgtcagaaGGCAAAATTAAAtgatgtagcagcaagtcataaagaa g" /listShort="spoIVB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2216762..2218492) /gene="recN" /locus_tag="BSU_24240" /old_locus_tag="BSU24240" /function="16.8: Protect" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:15186413, 15849320, 15948952, 16009134, 16061691, 16385024, 17999999, 20360008, 21517913, 23380520, 24373815" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15186413, 15849320, 15948952, 16009134, 16061691, 16385024, 17999999, 20360008, 21517913, 23380520, 24373815; Product type f : factor" /codon_start=1 /transl_table=11 /product="factor for double strand breaks DNA repair and genetic recombination" /protein_id="NP_390304.2" /db_xref="EnsemblGenomes-Gn:BSU24240" /db_xref="EnsemblGenomes-Tr:CAB14355" /db_xref="GOA:P17894" /db_xref="InterPro:IPR004604" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10310" /db_xref="UniProtKB/Swiss-Prot:P17894" /translation="MLAELSIKNFAIIEELTVSFERGLTVLTGETGAGKSIIIDAISL LVGGRGSSEFVRYGEAKAELEGLFLLESGHPVLGVCAEQGIDVSDEMIVMRRDISTSG KSVCRVNGKLVTIASLREIGRLLLDIHGQHDNQLLMEDENHLQLLDKFAGAEVESALK TYQEGYQRYVKLLKKLKQLSESEQEMAHRLDLIQFQLEEIESAKLELNEDEQLQEERQ QISNFEKIYESLQNAYNALRSEQGGLDWVGMASAQLEDISDINEPLKKMSESVSNSYY LLEDATFQMRNMLDELEFDPERLNYIETRLNEIKQLKRKYGATVEDILEYASKIEEEI DQIENRDSHLQSLKKELDSVGKDVAVEAANVSQIRKTWAKKLADEIHRELKSLYMEKS TFDTEFKVRTASRNEEAPLVNGQPVQLTEQGIDLVKFLISTNTGEPLKSLSKVASGGE LSRVMLAIKSIFSSQQDVTSIIFDEVDTGVSGRVAQAIAEKIHKVSIGSQVLCITHLP QVAAMADTHLYIAKELKDGRTTTRVKPLSKQEKVAEIGRMIAGVEVTDLTKRHAKELL KQADQVKTTG*" /label="recN CDS" gene complement(2216762..2218492) /gene="recN" /locus_tag="BSU_24240" /old_locus_tag="BSU24240" /label="recN gene" downshifts complement(2216777) /Source="Nicolas_upshifts" /id="D1267" /incds=0 /nref=232 /ntot=260 /MaxReadThrough="1.73202" /MaxDrop="6.33427" /score="20.028822" /energy="-12.4" /TU="NA" /idTUdmin="U1895" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2218529..2218978) /gene="argR" /locus_tag="BSU_24250" /old_locus_tag="BSU24250" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:180070, 9194709, 9383188, 11305941, 11856827, 17020585, 17576690, 18007040, 18455186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 180070, 9194709, 9383188, 11305941, 11856827, 17020585, 17576690, 18007040, 18455186; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (AhrC(ArgR)-arginine)" /protein_id="NP_390305.1" /db_xref="EnsemblGenomes-Gn:BSU24250" /db_xref="EnsemblGenomes-Tr:CAB14356" /db_xref="GOA:P17893" /db_xref="InterPro:IPR001669" /db_xref="InterPro:IPR020899" /db_xref="InterPro:IPR020900" /db_xref="InterPro:IPR024946" /db_xref="InterPro:IPR036251" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:1F9N" /db_xref="PDB:2P5K" /db_xref="PDB:2P5L" /db_xref="PDB:2P5M" /db_xref="SubtiList:BG10309" /db_xref="UniProtKB/Swiss-Prot:P17893" /translation="MNKGQRHIKIREIITSNEIETQDELVDMLKQDGYKVTQATVSRD IKELHLVKVPTNNGSYKYSLPADQRFNPLSKLKRALMDAFVKIDSASHMIVLKTMPGN AQAIGALMDNLDWDEMMGTICGDDTILIICRTPEDTEGVKNRLLELL*" /label="argR CDS" gene complement(2218529..2218978) /gene="argR" /locus_tag="BSU_24250" /old_locus_tag="BSU24250" /label="argR gene" S_feature complement(2218979..2219064) /Source="Nicolas_S_feature" /locus_tag="new_2522774_2522859_c" /HighExp="H2O2, G180, G135, G150, Oxctl, Heat, Paraq, C30, dia15, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.999, 0.993, 1" /TUlongSig="SigB" /TUlongPSig="0.742" /label="S915" CDS complement(2219076..2219921) /gene="yqxC" /locus_tag="BSU_24260" /old_locus_tag="BSU24260" /EC_number="2.1.1.-" /function="9.4: RNA processing" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16014871, 22333191, 24809820; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 2'-O-ribose RNA methyltransferase" /protein_id="NP_390306.2" /db_xref="EnsemblGenomes-Gn:BSU24260" /db_xref="EnsemblGenomes-Tr:CAB14357" /db_xref="GOA:P19672" /db_xref="InterPro:IPR002877" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR004538" /db_xref="InterPro:IPR029063" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG10308" /db_xref="UniProtKB/Swiss-Prot:P19672" /translation="MTSKKERLDVLLVERGLAETREKAKRAIMAGIVYSNENRLDKPG EKIDRDLPLTVKGNPLRYVSRGGLKLEKALKEFPVSVKDKIMIDIGSSTGGFTDCALQ NGAKQSYAVDVGYNQLAWKLRQDERVVVMERTNFRYATPADFTKGMPEFATIDVSFIS LRLILPVLRTLLVPGSDCMALVKPQFEAGRESVGKKGIVRDPKVHADVLKRMISFSAA EGYICKGLSFSPITGGDGNIEFLLHLHWPGEGQEGQELPEEEIMRVVEEAHKTLKEKK ADVPE*" /label="yqxC CDS" gene complement(2219076..2219921) /gene="yqxC" /locus_tag="BSU_24260" /old_locus_tag="BSU24260" /label="yqxC gene" downshifts complement(2219109) /Source="Nicolas_upshifts" /id="D1268" /incds=0 /nref=1 /ntot=65 /MaxReadThrough="5.65358" /MaxDrop="2.6955" /score="4.97422627" /energy="-9.4" /TU="U1895,U1896,U1898" /idTUdmin="U1895" /TUdmin="-2332" /isTUend="FALSE" /label="downshifts" CDS complement(2219918..2221819) /gene="dxs" /locus_tag="BSU_24270" /old_locus_tag="BSU24270" /EC_number="2.2.1.7" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 12882400, 15292217, 17458547, 23840410, 25212876; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="1-deoxyxylulose-5-phosphate synthase" /protein_id="NP_390307.1" /db_xref="EnsemblGenomes-Gn:BSU24270" /db_xref="EnsemblGenomes-Tr:CAB14358" /db_xref="GOA:P54523" /db_xref="InterPro:IPR005474" /db_xref="InterPro:IPR005475" /db_xref="InterPro:IPR005477" /db_xref="InterPro:IPR009014" /db_xref="InterPro:IPR020826" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR033248" /db_xref="SubtiList:BG11715" /db_xref="UniProtKB/Swiss-Prot:P54523" /translation="MDLLSIQDPSFLKNMSIDELEKLSDEIRQFLITSLSASGGHIGP NLGVVELTVALHKEFNSPKDKFLWDVGHQSYVHKLLTGRGKEFATLRQYKGLCGFPKR SESEHDVWETGHSSTSLSGAMGMAAARDIKGTDEYIIPIIGDGALTGGMALEALNHIG DEKKDMIVILNDNEMSIAPNVGAIHSMLGRLRTAGKYQWVKDELEYLFKKIPAVGGKL AATAERVKDSLKYMLVSGMFFEELGFTYLGPVDGHSYHELIENLQYAKKTKGPVLLHV ITKKGKGYKPAETDTIGTWHGTGPYKINTGDFVKPKAAAPSWSGLVSGTVQRMAREDG RIVAITPAMPVGSKLEGFAKEFPDRMFDVGIAEQHAATMAAAMAMQGMKPFLAIYSTF LQRAYDQVVHDICRQNANVFIGIDRAGLVGADGETHQGVFDIAFMRHIPNMVLMMPKD ENEGQHMVHTALSYDEGPIAMRFPRGNGLGVKMDEQLKTIPIGTWEVLRPGNDAVILT FGTTIEMAIEAAEELQKEGLSVRVVNARFIKPIDEKMMKSILKEGLPILTIEEAVLEG GFGSSILEFAHDQGEYHTPIDRMGIPDRFIEHGSVTALLEEIGLTKQQVANRIRLLMP PKTHKGIGS*" /label="dxs CDS" gene complement(2219918..2221819) /gene="dxs" /locus_tag="BSU_24270" /old_locus_tag="BSU24270" /label="dxs gene" promotor_-35 2221027..2221033 /Source="Nicolas_upshift_promotors" /id="U1894" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=952 /SigmaFactorBS="tgcagaagaacagggcctttcgtttttttggCGTATTGaaga ttctcaatcaGCTCATGATAAGaatgtccgtccactgggcccaaatacgtaaaaccga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2221048..2221059 /Source="Nicolas_upshift_promotors" /id="U1894" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=952 /SigmaFactorBS="tgcagaagaacagggcctttcgtttttttggCGTATTGaaga ttctcaatcaGCTCATGATAAGaatgtccgtccactgggcccaaatacgtaaaaccga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2221056 /Source="Nicolas_upshifts" /id="U1894" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=952 /SigmaFactorBS="tgcagaagaacagggcctttcgtttttttggCGTATTGaaga ttctcaatcaGCTCATGATAAGaatgtccgtccactgggcccaaatacgtaaaaccga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2221820..2221948) /Source="Nicolas_S_feature" /locus_tag="new_2525615_2525743_c" /HighExp="Salt, Heat, dia15, H2O2, HiOs, Cold, T-5.40H, T3.30H, SMM, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.999, 0.993, 1" /TUlongSig="SigB" /TUlongPSig="0.742" /label="S916" promotor_-10 complement(2221943..2221962) /Source="Nicolas_upshift_promotors" /id="U1895" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.508491508491508" /psig="0.999000999001" /xcortree=2286 /SigmaFactorBS="gcaagagatcactaaaacgatcctaATTTGAAgcggctgcac gaggTATGGTAAAATGTAAGCAGTttatatgaaaaatgaaaaggaaaagcgcgtttgt c" /listShort="S916, dxs, yqxC, S915, ahrC, recN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2221948) /Source="Nicolas_upshifts" /id="U1895" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.508491508491508" /psig="0.999000999001" /xcortree=2286 /SigmaFactorBS="gcaagagatcactaaaacgatcctaATTTGAAgcggctgcac gaggTATGGTAAAATGTAAGCAGTttatatgaaaaatgaaaaggaaaagcgcgtttgt c" /listShort="S916, dxs, yqxC, S915, ahrC, recN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2221977..2221983) /Source="Nicolas_upshift_promotors" /id="U1895" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.508491508491508" /psig="0.999000999001" /xcortree=2286 /SigmaFactorBS="gcaagagatcactaaaacgatcctaATTTGAAgcggctgcac gaggTATGGTAAAATGTAAGCAGTttatatgaaaaatgaaaaggaaaagcgcgtttgt c" /listShort="S916, dxs, yqxC, S915, ahrC, recN" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2221994..2222884) /gene="ispA" /locus_tag="BSU_24280" /old_locus_tag="BSU24280" /EC_number="2.5.1.10" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8755734, 12682299, 17147392, 23569278; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="farnesyl diphosphate synthase" /protein_id="NP_390308.2" /db_xref="EnsemblGenomes-Gn:BSU24280" /db_xref="EnsemblGenomes-Tr:CAB14359" /db_xref="GOA:P54383" /db_xref="InterPro:IPR000092" /db_xref="InterPro:IPR008949" /db_xref="InterPro:IPR033749" /db_xref="SubtiList:BG11714" /db_xref="UniProtKB/Swiss-Prot:P54383" /translation="MTNKLTSFLADRKKTIENQLSVYTEKLDMPDSLKKSMLYSLQAG GKRLRPLIVLAVLNAYGKSEKDGIPVGCAVEMIHTYSLIHDDLPCMDDDDLRRGKPTN HKVFGEATAVLAGDGLLTESFKLITSHVSDEVSAEKRLRLVNELISAAGTEGMVGGQV ADMEAENRQVTLEELESIHERKTAKLLGFCVIAGAILADAPEEDIETLRTFSSHIGIG FQIRDDILDLEGSEEKIGKRVGSDTTNDKSTYPSLLSLEGAKHKLDVHIKEAKRLIGG LSLQKDLLYELCDLIAARDH*" /label="ispA CDS" gene complement(2221994..2222884) /gene="ispA" /locus_tag="BSU_24280" /old_locus_tag="BSU24280" /label="ispA gene" CDS complement(2222874..2223128) /gene="xseB" /locus_tag="BSU_24290" /old_locus_tag="BSU24290" /EC_number="3.1.11.6" /function="16.6: Maintain" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11381137, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exodeoxyribonuclease VII (small subunit)" /protein_id="NP_390309.2" /db_xref="EnsemblGenomes-Gn:BSU24290" /db_xref="EnsemblGenomes-Tr:CAB14360" /db_xref="GOA:P54522" /db_xref="InterPro:IPR003761" /db_xref="InterPro:IPR037004" /db_xref="SubtiList:BG11713" /db_xref="UniProtKB/Swiss-Prot:P54522" /translation="MTDVKKNENMTFEEAMKGLESIVSKLEEGDVPLEQAINYFQEGM ALSKMCHEKLQKVEKQMDFILKEDGELAPFSVQEEDEGDK*" /label="xseB CDS" gene complement(2222874..2223128) /gene="xseB" /locus_tag="BSU_24290" /old_locus_tag="BSU24290" /label="xseB gene" CDS complement(2223125..2224471) /gene="xseA" /locus_tag="BSU_24300" /old_locus_tag="BSU24300" /EC_number="3.1.11.6" /function="16.9: Replicate" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 17182742; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exodeoxyribonuclease VII (large subunit)" /protein_id="NP_390310.2" /db_xref="EnsemblGenomes-Gn:BSU24300" /db_xref="EnsemblGenomes-Tr:CAB14361" /db_xref="GOA:P54521" /db_xref="InterPro:IPR003753" /db_xref="InterPro:IPR020579" /db_xref="InterPro:IPR025824" /db_xref="SubtiList:BG11712" /db_xref="UniProtKB/Swiss-Prot:P54521" /translation="MGEAAYVTVSALTKYIKRKFDVDPHLENIWIKGELSNVKIHTRG HIYFTLKDENARMQSVMFARQSERLPFKPENGMKVLVRGGISVYEPSGNYQLYAKEMQ PDGVGALYLAYEELKKKLAGEGLFDDRYKKQIPAFPATIGVVTSPTGAAVRDVITTLK RRYPLVKVIVLPALVQGENASRSIVTRIEEANEKEICDVLIVGRGGGSIEELWAFNEE IVARAIFASNIPIISAVGHETDFTISDFVADIRAATPTGAAEIAVPHTTDLIERTKTA EVRMTRAMQQHLGQKKERIQTLQSSYAFRFPKRLYAQKEQQFDLAYQQFQAQLTALLD RKSRQLERETYRLEALHPHEQLKQARTRYQEQTNQLRKNMNIQMKQLHSQFQTVLGKL NALSPLQVMERGYSLAYKEDKLIKSVSQIEEQDRLEIKLKDGVLTCEVLEKRGEEK*" /label="xseA CDS" gene complement(2223125..2224471) /gene="xseA" /locus_tag="BSU_24300" /old_locus_tag="BSU24300" /label="xseA gene" S_feature complement(2224472..2224608) /Source="Nicolas_S_feature" /locus_tag="new_2528267_2528403_c" /HighExp="H2O2, G180, G135, Cold, G150, Paraq, Oxctl, LBGstat, LPh, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB, SigA" /TUshortPSig="0.993, 0.742, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S917" CDS complement(2224609..2225460) /gene="folD" /locus_tag="BSU_24310" /old_locus_tag="BSU24310" /EC_number="1.5.1.5" /EC_number="3.5.4.9" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7061514, 9454603, 12682299, 19171795; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylenetetrahydrofolate dehydrogenase; methenyltetrahydrofolate cyclohydrolase" /protein_id="NP_390311.1" /db_xref="EnsemblGenomes-Gn:BSU24310" /db_xref="EnsemblGenomes-Tr:CAB14362" /db_xref="GOA:P54382" /db_xref="InterPro:IPR000672" /db_xref="InterPro:IPR020630" /db_xref="InterPro:IPR020631" /db_xref="InterPro:IPR020867" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11711" /db_xref="UniProtKB/Swiss-Prot:P54382" /translation="MTATIIDGKETAREKREQLAKEVEELKKQGVTPGLAVILIGDDP ASHSYVRGKKKAAETMGMNFKLDQFDSSLTEAELLSIIDQYNQDPEFHGILVQLPLPD HISEKAVIERISPDKDVDGFHPLNVGKMLLGEDTFLPCTPHGIVELLKKTNIDLSGKE VVVVGRSNIVGKPVGQLLLNENATVTYCHSRTENITEHTKKADILVVAVGRANFISAD QIKEGAVVIDVGVNRLENGKLCGDVEFEGAKEKASFITPVPGGVGPMTITMLAHNTVK SAKRTLS*" /label="folD CDS" gene complement(2224609..2225460) /gene="folD" /locus_tag="BSU_24310" /old_locus_tag="BSU24310" /label="folD gene" CDS complement(2225472..2225867) /gene="nusB" /locus_tag="BSU_24320" /old_locus_tag="BSU24320" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16707701, 16946247, 27964882; Product type f: factor" /codon_start=1 /transl_table=11 /product="transcription termination factor NusB" /protein_id="NP_390312.2" /db_xref="EnsemblGenomes-Gn:BSU24320" /db_xref="EnsemblGenomes-Tr:CAB14363" /db_xref="GOA:P54520" /db_xref="InterPro:IPR006027" /db_xref="InterPro:IPR011605" /db_xref="InterPro:IPR035926" /db_xref="SubtiList:BG11710" /db_xref="UniProtKB/Swiss-Prot:P54520" /translation="MKRRTAREKALQALFQIDVSDIAVNEAIEHALDEEKTDPFFEQL VHGVLEHQDQLDEMISKHLVNWKLDRIANVDRAILRLAAYEMAYAEDIPVNVSMNEAI ELAKRFGDDKATKFVNGVLSNIKSDIEQS*" /label="nusB CDS" gene complement(2225472..2225867) /gene="nusB" /locus_tag="BSU_24320" /old_locus_tag="BSU24320" /label="nusB gene" misc_feature complement(2225910..2225929) /Source="Nicolas_upshift_promotors" /id="U1896" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.416583416583417" /psig="0.993006993006993" /xcortree=2425 /SigmaFactorBS="tgaaaatattcggtaatagggtaaaaaaaccttgatttcaat atgcggatacgaaaaaaaTATGTTATGATCTCTTTGTGgcttaacgacaagcggataa a" /listShort="nusB, folD, S917, xseA, xseB, ispA, S916, dxs, yqxC, S915, ahrC, recN" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2225929) /Source="Nicolas_upshifts" /id="U1896" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.416583416583417" /psig="0.993006993006993" /xcortree=2425 /SigmaFactorBS="tgaaaatattcggtaatagggtaaaaaaaccttgatttcaat atgcggatacgaaaaaaaTATGTTATGATCTCTTTGTGgcttaacgacaagcggataa a" /listShort="nusB, folD, S917, xseA, xseB, ispA, S916, dxs, yqxC, S915, ahrC, recN" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2225931..2226093) /Source="Nicolas_S_feature" /locus_tag="new_2529726_2529888_c" /HighExp="G180, G150, Oxctl, Etha, G135, GM 120, dia0, HPh, MG 150, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigA" /TUshortPSig="0.742, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S918" CDS complement(2226131..2226538) /gene="yqhY" /locus_tag="BSU_24330" /old_locus_tag="BSU24330" /function="16.13: Shape" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16014871, 17114254, 22720735, 28579978" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16014871, 17114254, 22720735, 28579978; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="alkaline shock protein" /protein_id="NP_390313.2" /db_xref="EnsemblGenomes-Gn:BSU24330" /db_xref="EnsemblGenomes-Tr:CAB14364" /db_xref="InterPro:IPR005531" /db_xref="SubtiList:BG11709" /db_xref="UniProtKB/Swiss-Prot:P54519" /translation="MKDNSLLKMDHEDTHLGKVEIAPEVIEVIAGIAASEVDGVAEMR GNFATGVVERFGKVNHGKGVKVDLADDGITIDVYCVVTFGVSIPKVAASVQENIRQTL LNMTSLSINEINIHIVGIQFDTKAQEVQIDEEM*" /label="yqhY CDS" gene complement(2226131..2226538) /gene="yqhY" /locus_tag="BSU_24330" /old_locus_tag="BSU24330" /label="yqhY gene" downshifts complement(2226138) /Source="Nicolas_upshifts" /id="D1269" /incds=0 /nref=6 /ntot=76 /MaxReadThrough="6.4099" /MaxDrop="4.1473" /score="9.44795832" /energy="-9.5" /TU="U1897,U1898" /idTUdmin="U1899" /TUdmin=2409 /isTUend="FALSE" /label="downshifts" CDS complement(2226559..2227911) /gene="accC" /locus_tag="BSU_24340" /old_locus_tag="BSU24340" /EC_number="6.3.4.14" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7592499, 12682299, 14594796" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7592499, 12682299, 14594796; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetyl-CoA carboxylase subunit (biotin carboxylase subunit)" /protein_id="NP_390314.2" /db_xref="EnsemblGenomes-Gn:BSU24340" /db_xref="EnsemblGenomes-Tr:CAB14365" /db_xref="GOA:P49787" /db_xref="InterPro:IPR004549" /db_xref="InterPro:IPR005479" /db_xref="InterPro:IPR005481" /db_xref="InterPro:IPR005482" /db_xref="InterPro:IPR011054" /db_xref="InterPro:IPR011761" /db_xref="InterPro:IPR011764" /db_xref="InterPro:IPR013815" /db_xref="InterPro:IPR016185" /db_xref="SubtiList:BG11384" /db_xref="UniProtKB/Swiss-Prot:P49787" /translation="MIKKLLIANRGEIAVRIIRACRELGIETVAVYSEADKDALHVQM ADEAFCIGPKASKDSYLNVTNIVSVAKLTGTDAIHPGYGFLAENADFAELCEEVNVTF VGPSADAISKMGTKDVARETMKQAGVPIVPGSQGIIENVEEAVSLANEIGYPVIIKAT AGGGGKGIRVARTEEELINGIKITQQEAATAFGNPGVYIEKYIEDFRHVEIQVLADNY GNTIHLGERDCSIQRRLQKLLEESPSPALDSEIREQMGDAAVKAAKAVGYTGAGTVEF IYDYNEQRYYFMEMNTRIQVEHPVTEMVTGTDLIKEQIKVASGMELSLKQEDVEFEGW AIECRINAENPSKNFMPSPGEIKMYLPPGGLGVRVDSAAYPGYSIPPYYDSMIAKVIT YGKTRDEAIARMKRALSEFVIEGIETTIPFHLKLLEHETFVSGEFNTKFLETYDVMGS *" /label="accC CDS" gene complement(2226559..2227911) /gene="accC" /locus_tag="BSU_24340" /old_locus_tag="BSU24340" /label="accC gene" promotor_-10 complement(2227440..2227459) /Source="Nicolas_upshift_promotors" /id="U1897" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.742257742257742" /psig="0.742257742257742" /xcortree=127 /SigmaFactorBS="gggaattatagaaaatgtggaagaagcGGTTTCGcttgctaa tgaaatTGGGTATCCTGTAATTATAAaagccaccgcaggcggaggcggaaaaggaatt a" /listShort="yqhY, S918, nusB, folD, S917, xseA, xseB, ispA" /listLong="S916, dxs, yqxC, S915, ahrC, recN" /label="promotor_-10" upshifts complement(2227447) /Source="Nicolas_upshifts" /id="U1897" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.742257742257742" /psig="0.742257742257742" /xcortree=127 /SigmaFactorBS="gggaattatagaaaatgtggaagaagcGGTTTCGcttgctaa tgaaatTGGGTATCCTGTAATTATAAaagccaccgcaggcggaggcggaaaaggaatt a" /listShort="yqhY, S918, nusB, folD, S917, xseA, xseB, ispA" /listLong="S916, dxs, yqxC, S915, ahrC, recN" /label="upshifts" promotor_-35 complement(2227474..2227480) /Source="Nicolas_upshift_promotors" /id="U1897" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.742257742257742" /psig="0.742257742257742" /xcortree=127 /SigmaFactorBS="gggaattatagaaaatgtggaagaagcGGTTTCGcttgctaa tgaaatTGGGTATCCTGTAATTATAAaagccaccgcaggcggaggcggaaaaggaatt a" /listShort="yqhY, S918, nusB, folD, S917, xseA, xseB, ispA" /listLong="S916, dxs, yqxC, S915, ahrC, recN" /label="promotor_-35" CDS complement(2227923..2228402) /gene="accB" /locus_tag="BSU_24350" /old_locus_tag="BSU24350" /EC_number="6.4.1.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7592499, 12682299, 14594796, 15518551" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7592499, 12682299, 14594796, 15518551; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetyl-CoA carboxylase subunit (biotin carboxyl carrier subunit)" /protein_id="NP_390315.1" /db_xref="EnsemblGenomes-Gn:BSU24350" /db_xref="EnsemblGenomes-Tr:CAB14366" /db_xref="GOA:P49786" /db_xref="InterPro:IPR000089" /db_xref="InterPro:IPR001249" /db_xref="InterPro:IPR001882" /db_xref="InterPro:IPR011053" /db_xref="SubtiList:BG11383" /db_xref="UniProtKB/Swiss-Prot:P49786" /translation="MLNIKEIHELIKAIDESTIDEFVYENEGVSLKLKKHEAGTVQVM QQAPAAPVQAQAPQAVQPQAQQAAAPAQEAPKQDENLHKITSPMVGTFYASSSPEAGP YVTAGSKVNENTVVCIVEAMKLFNEIEAEVKGEIVEVLVENGQLVEYGQPLFLVKAE* " /label="accB CDS" gene complement(2227923..2228402) /gene="accB" /locus_tag="BSU_24350" /old_locus_tag="BSU24350" /label="accB gene" promotor_-10 complement(2228461..2228480) /Source="Nicolas_upshift_promotors" /id="U1898" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.727272727272727" /psig=1 /xcortree=2334 /SigmaFactorBS="caagcgggctttttgcgttgctgtcatattaGAGTTGAAttc aaaagtccgcTCCTGTAAGATGAACATAGTatgtacttttagtagtaacctataaaaa a" /listShort="accB, accC, yqhY, S918, nusB, folD, S917, xseA, xseB, ispA, S916, dxs, yqxC, S915, ahrC, recN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2228472) /Source="Nicolas_upshifts" /id="U1898" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.727272727272727" /psig=1 /xcortree=2334 /SigmaFactorBS="caagcgggctttttgcgttgctgtcatattaGAGTTGAAttc aaaagtccgcTCCTGTAAGATGAACATAGTatgtacttttagtagtaacctataaaaa a" /listShort="accB, accC, yqhY, S918, nusB, folD, S917, xseA, xseB, ispA, S916, dxs, yqxC, S915, ahrC, recN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2228494..2228501) /Source="Nicolas_upshift_promotors" /id="U1898" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.727272727272727" /psig=1 /xcortree=2334 /SigmaFactorBS="caagcgggctttttgcgttgctgtcatattaGAGTTGAAttc aaaagtccgcTCCTGTAAGATGAACATAGTatgtacttttagtagtaacctataaaaa a" /listShort="accB, accC, yqhY, S918, nusB, folD, S917, xseA, xseB, ispA, S916, dxs, yqxC, S915, ahrC, recN" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2228558..2229214) /gene="spoIIIAH" /locus_tag="BSU_24360" /old_locus_tag="BSU24360" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15028710, 15752199, 16959571, 1766372" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15028710, 15752199, 16959571, 1766372; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage III sporulation ratchet engulfment protein" /protein_id="NP_390316.2" /db_xref="EnsemblGenomes-Gn:BSU24360" /db_xref="EnsemblGenomes-Tr:CAB14367" /db_xref="GOA:P49785" /db_xref="InterPro:IPR024232" /db_xref="PDB:3TUF" /db_xref="PDB:3UZ0" /db_xref="SubtiList:BG11415" /db_xref="UniProtKB/Swiss-Prot:P49785" /translation="MLKKQTVWLLTMLSLVVVLSVYYIMSPESKNAVQMQSEKSASDS GEVATEKAPAKQDTKEKSGTETEKGKEDGTKGTKDSSADKETSAEASEKGTVVTETAD DDLFTTYRLDLEDARSKEREELNAIVSSDDATAKEKSEAYDKMTALSEVEGTEKQLET LIKTQGYEDALVNAEGDKINITVKSDKHSKSKATAIIDLVAKEIKTMKDVAVTFEPSK *" /label="spoIIIAH CDS" gene complement(2228558..2229214) /gene="spoIIIAH" /locus_tag="BSU_24360" /old_locus_tag="BSU24360" /label="spoIIIAH gene" downshifts complement(2228565) /Source="Nicolas_upshifts" /id="D1270" /incds=0 /nref=26 /ntot=57 /MaxReadThrough="0.0903599999999987" /MaxDrop="6.40434" /score="21.0450747" /energy="-13" /TU="NA" /idTUdmin="U1899" /TUdmin="-18" /isTUend="TRUE" /label="downshifts" CDS complement(2229215..2229904) /gene="spoIIIAG" /locus_tag="BSU_24370" /old_locus_tag="BSU24370" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1766372, 15028710, 28784753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766372, 15028710, 28784753; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage III sporulation engulfment assembly protein" /protein_id="NP_390317.2" /db_xref="EnsemblGenomes-Gn:BSU24370" /db_xref="EnsemblGenomes-Tr:CAB14368" /db_xref="GOA:P49784" /db_xref="InterPro:IPR014195" /db_xref="SubtiList:BG11414" /db_xref="UniProtKB/Swiss-Prot:P49784" /translation="MNKNGLWNVLKKQFLPGQTKDGEKPKLTKYHYFLFVFVLGVSFM LVSQLFSSPEKTENAKTITAVSSQHSADSKEKTAEVFKASKSDKPKDSIDDYEKEYEN QLKEILETIIGVDDVSVVVNVDATSLKVYEKNKSNKNTTTEETDKEGGKRSVTDQSSE EEIVMIKNGDKETPVVVQTKKPDIRGVLVVAQGVDNVQIKQTIIEAVTRVLDVPSHRV AVAPKKIKEDS*" /label="spoIIIAG CDS" gene complement(2229215..2229904) /gene="spoIIIAG" /locus_tag="BSU_24370" /old_locus_tag="BSU24370" /label="spoIIIAG gene" CDS complement(2229897..2230517) /gene="spoIIIAF" /locus_tag="BSU_24380" /old_locus_tag="BSU24380" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1766372, 15028710, 17693505, 28784753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766372, 15028710, 17693505, 28784753; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage III sporulation protein (feeding tube apparatus)" /protein_id="NP_390318.1" /db_xref="EnsemblGenomes-Gn:BSU24380" /db_xref="EnsemblGenomes-Tr:CAB14369" /db_xref="GOA:P49783" /db_xref="InterPro:IPR014245" /db_xref="SubtiList:BG11413" /db_xref="UniProtKB/Swiss-Prot:P49783" /translation="MSFLTEWLTTIVLFILFAIVIDMLLPSSSMQKYAKMVVSLLLIV VMLTPIFKLFKTDPEVIFEYLTKNGQSESADIKNQINSKKIEIQASQRAYILEEMAVQ LKKKAEERFSHDEYKVGRIKLTAGEKVDSEEDIKTISVYMAPSSEKTVQTVAPVHIDT DHAYVTKEAAEQKEAKQIQTQLADIWEIGSEKITVHMEGGESVGNE*" /label="spoIIIAF CDS" gene complement(2229897..2230517) /gene="spoIIIAF" /locus_tag="BSU_24380" /old_locus_tag="BSU24380" /label="spoIIIAF gene" promotor_-10 complement(2230223..2230241) /Source="Nicolas_upshift_promotors" /id="U1899" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=981 /SigmaFactorBS="tctgccgacataaaaaatcaaatcaattcaaaaaaaataGAA ATAcaagcttcccagcgcGCATATATTCTAGAAGAAAtggctgtccaactaaaaaaga a" /listShort="spoIIIAG, spoIIIAH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2230241) /Source="Nicolas_upshifts" /id="U1899" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=981 /SigmaFactorBS="tctgccgacataaaaaatcaaatcaattcaaaaaaaataGAA ATAcaagcttcccagcgcGCATATATTCTAGAAGAAAtggctgtccaactaaaaaaga a" /listShort="spoIIIAG, spoIIIAH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2230257..2230262) /Source="Nicolas_upshift_promotors" /id="U1899" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=981 /SigmaFactorBS="tctgccgacataaaaaatcaaatcaattcaaaaaaaataGAA ATAcaagcttcccagcgcGCATATATTCTAGAAGAAAtggctgtccaactaaaaaaga a" /listShort="spoIIIAG, spoIIIAH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2230531..2231730) /gene="spoIIIAE" /locus_tag="BSU_24390" /old_locus_tag="BSU24390" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1766372, 15028710, 15849754, 16850406, 28784753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766372, 15028710, 15849754, 16850406, 28784753; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage III sporulation protein (feeding tube apparatus)" /protein_id="NP_390319.2" /db_xref="EnsemblGenomes-Gn:BSU24390" /db_xref="EnsemblGenomes-Tr:CAB14370" /db_xref="GOA:P49782" /db_xref="InterPro:IPR014194" /db_xref="SubtiList:BG11412" /db_xref="UniProtKB/Swiss-Prot:P49782" /translation="MKRFQWVLLLAVLIIAGRAEIVQAAGNAEQTEDHAETAEQLAER TAASLETDKIGEFWNDIMTEYGGLLPESQKGSLMEFINGDKSFSPQEWLKALFSYLFH EVLANGKLLGTLILLTIFCVILQLLQNAFQQSTVSKVAYSIVYMVLIILALNSFHVAI NYATEAIQTMTSFILALIPLLLALLASSGGAVSAAFFHPVILFLMNTSGLLIQNIVMP LIFLSAILSIVSTMTEQYKVTQLANLLRNIAIGALAVFLTIFLGVISVQGASAAVTDG ITLRTAKFITGNFIPVLGRMFTDATDTVISASLLLKNTVGILGVAILICIAAFPAIKV LSLAFIYKLAAAILQPLGGGPVITCLDVISKSVIYIFAALAIVSLMFFLSLTVIITAG NLTMMMK*" /label="spoIIIAE CDS" gene complement(2230531..2231730) /gene="spoIIIAE" /locus_tag="BSU_24390" /old_locus_tag="BSU24390" /label="spoIIIAE gene" CDS complement(2231749..2232150) /gene="spoIIIAD" /locus_tag="BSU_24400" /old_locus_tag="BSU24400" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1766372, 15028710, 15849754, 16850406, 28784753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766372, 15028710, 15849754, 16850406, 28784753; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage III sporulation protein (feeding tube apparatus)" /protein_id="NP_390320.1" /db_xref="EnsemblGenomes-Gn:BSU24400" /db_xref="EnsemblGenomes-Tr:CAB14371" /db_xref="GOA:P49781" /db_xref="InterPro:IPR014211" /db_xref="InterPro:IPR025664" /db_xref="SubtiList:BG11411" /db_xref="UniProtKB/Swiss-Prot:P49781" /translation="MQIDIVQIVGLGLIATFLSLIVKEQKPTFAFLIVVFAGCAIFLY LVDQIYDIIRMIEKIAINANVNMVYVETILKIIGIAYIAEFGAQLTKDAGQGAIASKI ELAGKILILVMAVPILTVIIETILGLIPSMS*" /label="spoIIIAD CDS" gene complement(2231749..2232150) /gene="spoIIIAD" /locus_tag="BSU_24400" /old_locus_tag="BSU24400" /label="spoIIIAD gene" CDS complement(2232157..2232363) /gene="spoIIIAC" /locus_tag="BSU_24410" /old_locus_tag="BSU24410" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1766372, 15028710, 17693505, 28784753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766372, 15028710, 17693505, 28784753; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage III sporulation protein (feeding tube apparatus)" /protein_id="NP_390321.1" /db_xref="EnsemblGenomes-Gn:BSU24410" /db_xref="EnsemblGenomes-Tr:CAB14372" /db_xref="GOA:P49780" /db_xref="InterPro:IPR009570" /db_xref="InterPro:IPR025664" /db_xref="SubtiList:BG11410" /db_xref="UniProtKB/Swiss-Prot:P49780" /translation="MGVDVNVIFQIAGVGIVVAFLHTILDQMGKKEYAQWVTLLGFIY ILFMVATIVDDLFKKIKAVFLFQG*" /label="spoIIIAC CDS" gene complement(2232157..2232363) /gene="spoIIIAC" /locus_tag="BSU_24410" /old_locus_tag="BSU24410" /label="spoIIIAC gene" CDS complement(2232386..2232901) /gene="spoIIIAB" /locus_tag="BSU_24420" /old_locus_tag="BSU24420" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1766372, 15028710, 17693505, 28784753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766372, 15028710, 17693505, 28784753; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage III sporulation protein (feeding tube apparatus)" /protein_id="NP_390322.1" /db_xref="EnsemblGenomes-Gn:BSU24420" /db_xref="EnsemblGenomes-Tr:CAB14373" /db_xref="GOA:Q01368" /db_xref="InterPro:IPR014198" /db_xref="SubtiList:BG10541" /db_xref="UniProtKB/Swiss-Prot:Q01368" /translation="MLKLLGAVFIVVATTWTGFEMAKIYTERPRQIRQLRAALQSLEA EIMYGHTPLHTASQQIAKQLAQPVSTLFSAFSDQLDKGSDSAKTAWEQSLKKVWDTLS LKKSEYEVLKQFGETLGIHDRISQQKHIKLALTHLEASEADAEQAQAKNEKMIKSLGF LAGLLLILLLM*" /label="spoIIIAB CDS" gene complement(2232386..2232901) /gene="spoIIIAB" /locus_tag="BSU_24420" /old_locus_tag="BSU24420" /label="spoIIIAB gene" CDS complement(2232895..2233818) /gene="spoIIIAA" /locus_tag="BSU_24430" /old_locus_tag="BSU24430" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1766372, 15028710, 17693505, 28784753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1766372, 15028710, 17693505, 28784753; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="ATP-binding stage III sporulation protein" /protein_id="NP_390323.1" /db_xref="EnsemblGenomes-Gn:BSU24430" /db_xref="EnsemblGenomes-Tr:CAB14374" /db_xref="GOA:Q01367" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR014217" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10540" /db_xref="UniProtKB/Swiss-Prot:Q01367" /translation="MNEIAEVLPESMKNALSEIPEQQWLEIEEVRIRINRPVELIRRG QPVYLSYAGTAEDAHLILSRLSNYSMYTLEEELKKGYVTIRGGHRVGLAGRVITENGG VKGLRDIASFNIRIARQKLGIAEPLLPYLYQNSWLNTLIIGPPQTGKTTLLRDLARLS STGKKNMLPVKTGIVDERSEIAGCLRGIPQHQFGQRIDVLDACPKAEGLMMMIRSMSP EVMIVDEIGRMEDTDALLEALHAGVSVIVSAHGWSISDLMKRPSLKRLWEERAFDRYL ELSRAKGPGTVSQIYDKDGNVLSRTTGVKTC*" /label="spoIIIAA CDS" gene complement(2232895..2233818) /gene="spoIIIAA" /locus_tag="BSU_24430" /old_locus_tag="BSU24430" /label="spoIIIAA gene" S_feature complement(2233819..2233893) /Source="Nicolas_S_feature" /locus_tag="new_2537614_2537688_c" /HighExp="S3, LoTm, S4, T5.0H, M9-stat, S5, BT, S7, S6, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S919" CDS complement(2233894..2234175) /gene="yqhV" /locus_tag="BSU_24440" /old_locus_tag="BSU24440" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390324.1" /db_xref="EnsemblGenomes-Gn:BSU24440" /db_xref="EnsemblGenomes-Tr:CAB14375" /db_xref="GOA:P49779" /db_xref="InterPro:IPR020390" /db_xref="SubtiList:BG11459" /db_xref="UniProtKB/Swiss-Prot:P49779" /translation="MKFLLGNINSTVLTMAGLRVLSSMIELTAAIVMLVTNDVRKAVV VNSILAIVGPLIFIITMTVGIYQIAGQLSYAKLILIFTGVVLILAGVHK*" /label="yqhV CDS" gene complement(2233894..2234175) /gene="yqhV" /locus_tag="BSU_24440" /old_locus_tag="BSU24440" /label="yqhV gene" promotor_-10 complement(2234195..2234213) /Source="Nicolas_upshift_promotors" /id="U1900" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=992 /SigmaFactorBS="ttttgtgcccaaaaacagaatctttcttttatacgaaaatga caAGACTActtcagcaagctagaGCATATCATATAAAAAAATgggaggttgggagagt g" /listShort="yqhV, S919, spoIIIAA, spoIIIAB, spoIIIAC, spoIIIAD, spoIIIAE, spoIIIAF" /listLong="spoIIIAG, spoIIIAH" /label="promotor_-10" upshifts complement(2234218) /Source="Nicolas_upshifts" /id="U1900" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=992 /SigmaFactorBS="ttttgtgcccaaaaacagaatctttcttttatacgaaaatga caAGACTActtcagcaagctagaGCATATCATATAAAAAAATgggaggttgggagagt g" /listShort="yqhV, S919, spoIIIAA, spoIIIAB, spoIIIAC, spoIIIAD, spoIIIAE, spoIIIAF" /listLong="spoIIIAG, spoIIIAH" /label="upshifts" promotor_-35 complement(2234229..2234234) /Source="Nicolas_upshift_promotors" /id="U1900" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=992 /SigmaFactorBS="ttttgtgcccaaaaacagaatctttcttttatacgaaaatga caAGACTActtcagcaagctagaGCATATCATATAAAAAAATgggaggttgggagagt g" /listShort="yqhV, S919, spoIIIAA, spoIIIAB, spoIIIAC, spoIIIAD, spoIIIAE, spoIIIAF" /listLong="spoIIIAG, spoIIIAH" /label="promotor_-35" CDS complement(2234320..2234877) /gene="efp" /locus_tag="BSU_24450" /old_locus_tag="BSU24450" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1956781, 14586115, 15066026, 15210970, 16014871, 27002156, 28787546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1956781, 14586115, 15066026, 15210970, 16014871, 27002156, 28787546; Product type f: factor" /codon_start=1 /transl_table=11 /product="elongation factor P" /protein_id="NP_390325.2" /db_xref="EnsemblGenomes-Gn:BSU24450" /db_xref="EnsemblGenomes-Tr:CAB14376" /db_xref="GOA:P49778" /db_xref="InterPro:IPR001059" /db_xref="InterPro:IPR008991" /db_xref="InterPro:IPR011768" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR013185" /db_xref="InterPro:IPR013852" /db_xref="InterPro:IPR014722" /db_xref="InterPro:IPR015365" /db_xref="InterPro:IPR020599" /db_xref="SubtiList:BG11460" /db_xref="UniProtKB/Swiss-Prot:P49778" /translation="MISVNDFRTGLTIEVDGGIWRVVDFQHVKPGKGAAFVRSKLRNL RTGAIQEKTFRAGEKVAKAQIETKTMQYLYANGDQHVFMDTSSYEQLELSATQIEEEL KYLLENMSVHIMMYQDETLGIELPNTVELKVVETEPGIKGDTASGGTKPAKTETGLVV NVPFFVNEGDTLVVNTSDGSYVSRA*" /label="efp CDS" gene complement(2234320..2234877) /gene="efp" /locus_tag="BSU_24450" /old_locus_tag="BSU24450" /label="efp gene" downshifts complement(2234332) /Source="Nicolas_upshifts" /id="D1271" /incds=0 /nref=256 /ntot=266 /MaxReadThrough="0.83852" /MaxDrop="7.73118" /score="27.4193827" /energy="-13.5" /TU="NA" /idTUdmin="U1901" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2234902..2235963) /gene="papA" /locus_tag="BSU_24460" /old_locus_tag="BSU24460" /EC_number="3.4.-.-" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:23144141, 26735940, 27002156" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23144141, 26735940, 27002156; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aminopeptidase (Met-Xaa and Xaa-Pro, Xaa-Pro-Xaa)" /protein_id="NP_390326.1" /db_xref="EnsemblGenomes-Gn:BSU24460" /db_xref="EnsemblGenomes-Tr:CAB14377" /db_xref="GOA:P54518" /db_xref="InterPro:IPR000587" /db_xref="InterPro:IPR000994" /db_xref="InterPro:IPR001131" /db_xref="InterPro:IPR001714" /db_xref="InterPro:IPR029149" /db_xref="InterPro:IPR036005" /db_xref="SubtiList:BG11708" /db_xref="UniProtKB/Swiss-Prot:P54518" /translation="MKLEKLRNLFGQLGIDGMLITSNTNVRYMTGFTGSAGLAVISGD KAAFITDFRYTEQAKVQVKGFEIIEHGGSLIQTTADTVESFGIKRLGFEQNSMTYGTY ASYSAVISDAELVPVAESVEKLRLIKSSEEIKILEEAAKIADDAFRHILTFMKPGISE IAVANELEFYMRSQGADSSSFDMIVASGLRSSLPHGVASDKLIESGDLVTLDFGAYYK GYCSDITRTVAVGQPSDQLKEIYQVVFDAQALGVAHIKPGMTGKEADALTRDHIAAKG YGDYFGHSTGHGLGMEVHESPGLSVRSSAILEPGMVVTVEPGIYIPETGGVRIEDDIV ITENGNRTITHSPKELIIL*" /label="papA CDS" gene complement(2234902..2235963) /gene="papA" /locus_tag="BSU_24460" /old_locus_tag="BSU24460" /label="papA gene" CDS complement(2235960..2236406) /gene="yqhS" /locus_tag="BSU_24470" /old_locus_tag="BSU24470" /EC_number="4.2.1.10" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10870960, 19099550; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-dehydroquinate dehydratase, type II" /protein_id="NP_390327.1" /db_xref="EnsemblGenomes-Gn:BSU24470" /db_xref="EnsemblGenomes-Tr:CAB14378" /db_xref="GOA:P54517" /db_xref="InterPro:IPR001874" /db_xref="InterPro:IPR018509" /db_xref="InterPro:IPR036441" /db_xref="PDB:1GQO" /db_xref="SubtiList:BG11707" /db_xref="UniProtKB/Swiss-Prot:P54517" /translation="MPHFLILNGPNVNRLGSREPEVFGRQTLTDIETDLFQFAEALHI QLTFFQSNHEGDLIDAIHEAEEQYSGIVLNPGALSHYSYAIRDAVSSISLPVVEVHLS NLYAREEFRHQSVIAPVAKGQIVGLGAEGYKLAVRYLLSQQGGESR*" /label="yqhS CDS" gene complement(2235960..2236406) /gene="yqhS" /locus_tag="BSU_24470" /old_locus_tag="BSU24470" /label="yqhS gene" promotor_-10 complement(2236455..2236474) /Source="Nicolas_upshift_promotors" /id="U1901" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.485514485514486" /psig="0.999000999001" /xcortree=2230 /SigmaFactorBS="gaaaagcttgcacgtgcgctgggaatgcatagagaatAGTGT ATAatccttttccagTATGATAAAATGTTCACGAGaagtgaacattttttacatgaga a" /listShort="yqhS, yqhT, efp" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2236471) /Source="Nicolas_upshifts" /id="U1901" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.485514485514486" /psig="0.999000999001" /xcortree=2230 /SigmaFactorBS="gaaaagcttgcacgtgcgctgggaatgcatagagaatAGTGT ATAatccttttccagTATGATAAAATGTTCACGAGaagtgaacattttttacatgaga a" /listShort="yqhS, yqhT, efp" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2236487..2236494) /Source="Nicolas_upshift_promotors" /id="U1901" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.485514485514486" /psig="0.999000999001" /xcortree=2230 /SigmaFactorBS="gaaaagcttgcacgtgcgctgggaatgcatagagaatAGTGT ATAatccttttccagTATGATAAAATGTTCACGAGaagtgaacattttttacatgaga a" /listShort="yqhS, yqhT, efp" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2236493..2237029) /gene="yqhR" /locus_tag="BSU_24480" /old_locus_tag="BSU24480" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390328.1" /db_xref="EnsemblGenomes-Gn:BSU24480" /db_xref="EnsemblGenomes-Tr:CAB14379" /db_xref="GOA:P54516" /db_xref="InterPro:IPR024563" /db_xref="SubtiList:BG11706" /db_xref="UniProtKB/Swiss-Prot:P54516" /translation="MMTSEKDTEQNEELNEKQKPPVSMAGRVAATGFCGGVLWSFVAY IAYLFHFSEISPNMILQPFVLGEWKKHGLGTVISIILIGVISIGAAFLYFLLLKRLKT MWPGILYGLVLWLLVFFVFNPIFPDVRTVTELTSDTIITTICIYLLYGLFVGYSISFE YNELNSEKLARALGMHRE*" /label="yqhR CDS" gene complement(2236493..2237029) /gene="yqhR" /locus_tag="BSU_24480" /old_locus_tag="BSU24480" /label="yqhR gene" promotor_-10 complement(2237042..2237053) /Source="Nicolas_upshift_promotors" /id="U1902" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=905 /SigmaFactorBS="caaattttactcgcagctgccaaaaagtgtgagcttttTTAT TGAcatttcattttttGGGCACACTTTAactggaggtgccatgatgacaagcgaaaaa g" /listShort="yqhR" /listLong="yqhS, yqhT, efp" /label="promotor_-10" upshifts complement(2237051) /Source="Nicolas_upshifts" /id="U1902" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=905 /SigmaFactorBS="caaattttactcgcagctgccaaaaagtgtgagcttttTTAT TGAcatttcattttttGGGCACACTTTAactggaggtgccatgatgacaagcgaaaaa g" /listShort="yqhR" /listLong="yqhS, yqhT, efp" /label="upshifts" promotor_-35 complement(2237067..2237073) /Source="Nicolas_upshift_promotors" /id="U1902" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=905 /SigmaFactorBS="caaattttactcgcagctgccaaaaagtgtgagcttttTTAT TGAcatttcattttttGGGCACACTTTAactggaggtgccatgatgacaagcgaaaaa g" /listShort="yqhR" /listLong="yqhS, yqhT, efp" /label="promotor_-35" promotor_-35 2237099..2237105 /Source="Nicolas_upshift_promotors" /id="U1903" /multdbtbs="SigB,SigF" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=746 /SigmaFactorBS="aatgaaatgtcaataaaaaagctcacactttttggcagctgC GAGTAAaatttgaaaataacGGGTATAATGCATGTAGAAaaagcaaggctatggcaat t" /listShort="yqhQ, yqhP" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2237118 /Source="Nicolas_upshifts" /id="U1903" /multdbtbs="SigB,SigF" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=746 /SigmaFactorBS="aatgaaatgtcaataaaaaagctcacactttttggcagctgC GAGTAAaatttgaaaataacGGGTATAATGCATGTAGAAaaagcaaggctatggcaat t" /listShort="yqhQ, yqhP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2237120..2237138 /Source="Nicolas_upshift_promotors" /id="U1903" /multdbtbs="SigB,SigF" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=746 /SigmaFactorBS="aatgaaatgtcaataaaaaagctcacactttttggcagctgC GAGTAAaatttgaaaataacGGGTATAATGCATGTAGAAaaagcaaggctatggcaat t" /listShort="yqhQ, yqhP" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 2237175..2237178 /Source="Nicolas_upshift_promotors" /id="U1904" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=3141 /SigmaFactorBS="aaggctatggcaattttttcagcctgtcaatCTAGaggttta gcgctgtTTCCTGTACAATAGAGTGAAaggaaatggttagcaatcctaaagaaatagg c" /listShort="yqhQ, yqhP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2237193..2237212 /Source="Nicolas_upshift_promotors" /id="U1904" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=3141 /SigmaFactorBS="aaggctatggcaattttttcagcctgtcaatCTAGaggttta gcgctgtTTCCTGTACAATAGAGTGAAaggaaatggttagcaatcctaaagaaatagg c" /listShort="yqhQ, yqhP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2237204 /Source="Nicolas_upshifts" /id="U1904" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=3141 /SigmaFactorBS="aaggctatggcaattttttcagcctgtcaatCTAGaggttta gcgctgtTTCCTGTACAATAGAGTGAAaggaaatggttagcaatcctaaagaaatagg c" /listShort="yqhQ, yqhP" /GFF_Attribute="listLong" /label="upshifts" CDS 2237256..2238212 /gene="yqhQ" /locus_tag="BSU_24490" /old_locus_tag="BSU24490" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390329.2" /db_xref="EnsemblGenomes-Gn:BSU24490" /db_xref="EnsemblGenomes-Tr:CAB14380" /db_xref="GOA:P54515" /db_xref="InterPro:IPR010787" /db_xref="SubtiList:BG11705" /db_xref="UniProtKB/Swiss-Prot:P54515" /translation="MSKHKVPPAYGGQAVVEGVMFGGKHHYVTAIRRTDGSIDFFKLP RKHNPKLNIVKKIPFLRGIAAIIEASANGTKHLNFSSERYGLDPSEDETLEQEEKKSS GLSMYLSLAVIGVLSFLFSKFVFTLVPVFLAELTRPIFSLNTAQIAIESLFKLILLLG YIYFLSMTPLIKRVFQYHGAEHKVINCYEQNLPITVENVQNQSRLHYRCGSSFILFTI IVGMFVYLLVPTDPLWLRVIDRVALIPVVLGISFEVLQLTNKVRDIPGLKLLGYPGLW LQLLTTKEPKDEQVEVAIESFNELLRLEALSEQNQKPSHNVI*" /label="yqhQ CDS" gene 2237256..2238212 /gene="yqhQ" /locus_tag="BSU_24490" /old_locus_tag="BSU24490" /label="yqhQ gene" CDS 2238252..2238647 /gene="yqhP" /locus_tag="BSU_24500" /old_locus_tag="BSU24500" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390330.1" /db_xref="EnsemblGenomes-Gn:BSU24500" /db_xref="EnsemblGenomes-Tr:CAB14381" /db_xref="GOA:P54514" /db_xref="SubtiList:BG11704" /db_xref="UniProtKB/Swiss-Prot:P54514" /translation="MNHRVQPIIAVLIALGAFGFLYVLVTNPGEMAKMAVTVIVAGII IYFIVKYVMNRNAGSEGAAFKKAAKQSRRRMKEQKAKHRAGHKGRVSHLRSVPSASKP KPMILKKKSQTQLTVIEGKKNKKKNRALF*" /label="yqhP CDS" gene 2238252..2238647 /gene="yqhP" /locus_tag="BSU_24500" /old_locus_tag="BSU24500" /label="yqhP gene" promotor_no_box 2238530..2238630 /Source="Nicolas_upshift_promotors" /id="U1905" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.578421578421578" /psig="0.007992007992008" /xcortree=275 /SigmaFactorBS="gcgaagcgttccgagcgccagcaagcctaagccgatgattct caagaaaaaaagccagactcagctgactgttatagaagggaaaaaaaataaaaagaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 2238590 /Source="Nicolas_upshifts" /id="U1905" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.578421578421578" /psig="0.007992007992008" /xcortree=275 /SigmaFactorBS="gcgaagcgttccgagcgccagcaagcctaagccgatgattct caagaaaaaaagccagactcagctgactgttatagaagggaaaaaaaataaaaagaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2238633 /Source="Nicolas_upshifts" /id="D1272" /incds=0 /nref=116 /ntot=283 /MaxReadThrough="2.23161" /MaxDrop="5.94415" /score="29.0609078" /energy="-8" /TU="NA" /idTUdmin="U1903" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2238644..2239519) /gene="yqhO" /locus_tag="BSU_24510" /old_locus_tag="BSU24510" /EC_number="3.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative lipase / acyl esterase" /protein_id="NP_390331.1" /db_xref="EnsemblGenomes-Gn:BSU24510" /db_xref="EnsemblGenomes-Tr:CAB14382" /db_xref="GOA:P54513" /db_xref="InterPro:IPR002641" /db_xref="InterPro:IPR016035" /db_xref="SubtiList:BG11703" /db_xref="UniProtKB/Swiss-Prot:P54513" /translation="MYIDGVFSGGGVKGIALAGAYEVLEEKGFRFKRVAGTSAGAIIA AFIASGYTSKEIHALIEEVDGEKLLDQRYSFLPLKMLQWVSIYWRLGLYKGDTIEKWI ADLLRAKGIRVFGDLQKGSLRLIASDLTNGTMIVLPDDLARYGLNPDMFPVARAVRMS CSIPYFFEPIKLKTDTGTATVVDGGVLSNFPIWLFSKERKRPVIGVTLAPRERERPKK NIRNAFELFGALFETMKDAHDARHIASRYEQNIIFLPVDDVMATDFHLTQQKKLALIE LGKRRTELFLKQWTY*" /label="yqhO CDS" gene complement(2238644..2239519) /gene="yqhO" /locus_tag="BSU_24510" /old_locus_tag="BSU24510" /label="yqhO gene" promotor_-10 complement(2239546..2239564) /Source="Nicolas_upshift_promotors" /id="U1906" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1086 /SigmaFactorBS="cgtcttttttgatacgctgacgccacccgtcattcgttGGTC TAtttcttcgcgtgtttTCTTAAAATGGTAATAAACgatcggatggagggggagggaa t" /listShort="yqhO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2239563) /Source="Nicolas_upshifts" /id="U1906" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1086 /SigmaFactorBS="cgtcttttttgatacgctgacgccacccgtcattcgttGGTC TAtttcttcgcgtgtttTCTTAAAATGGTAATAAACgatcggatggagggggagggaa t" /listShort="yqhO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2239580..2239585) /Source="Nicolas_upshift_promotors" /id="U1906" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1086 /SigmaFactorBS="cgtcttttttgatacgctgacgccacccgtcattcgttGGTC TAtttcttcgcgtgtttTCTTAAAATGGTAATAAACgatcggatggagggggagggaa t" /listShort="yqhO" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2239645..2240073) /gene="mntR" /locus_tag="BSU_24520" /old_locus_tag="BSU24520" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12950915, 15948947, 16533030, 17118401, 17176058, 17342524, 27748968, 28223356" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12950915, 15948947, 16533030, 17118401, 17176058, 17342524, 27748968, 28223356; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (hydrogen peroxide sensing, allosterically regulated by Mn2+)" /protein_id="NP_390332.2" /db_xref="EnsemblGenomes-Gn:BSU24520" /db_xref="EnsemblGenomes-Tr:CAB14383" /db_xref="GOA:P54512" /db_xref="InterPro:IPR001367" /db_xref="InterPro:IPR022687" /db_xref="InterPro:IPR022689" /db_xref="InterPro:IPR022897" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="InterPro:IPR036421" /db_xref="PDB:1ON1" /db_xref="PDB:1ON2" /db_xref="PDB:2EV0" /db_xref="PDB:2EV5" /db_xref="PDB:2EV6" /db_xref="PDB:2F5C" /db_xref="PDB:2F5D" /db_xref="PDB:2F5E" /db_xref="PDB:2F5F" /db_xref="PDB:2HYF" /db_xref="PDB:2HYG" /db_xref="PDB:3R60" /db_xref="PDB:3R61" /db_xref="PDB:4HV5" /db_xref="PDB:4HV6" /db_xref="PDB:4HX4" /db_xref="PDB:4HX7" /db_xref="PDB:4HX8" /db_xref="SubtiList:BG11702" /db_xref="UniProtKB/Swiss-Prot:P54512" /translation="MTTPSMEDYIEQIYMLIEEKGYARVSDIAEALAVHPSSVTKMVQ KLDKDEYLIYEKYRGLVLTSKGKKIGKRLVYRHELLEQFLRIIGVDEEKIYNDVEGIE HHLSWNSIDRIGDLVQYFEEDDARKKDLKSIQKKTEHHNQ*" /label="mntR CDS" gene complement(2239645..2240073) /gene="mntR" /locus_tag="BSU_24520" /old_locus_tag="BSU24520" /label="mntR gene" downshifts complement(2239672) /Source="Nicolas_upshifts" /id="D1273" /incds=0 /nref=322 /ntot=333 /MaxReadThrough="2.568" /MaxDrop="7.28707" /score="15.888362" /energy="-12" /TU="NA" /idTUdmin="U1908" /TUdmin=6 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2240108..2240127) /Source="Nicolas_upshift_promotors" /id="U1907" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2459 /SigmaFactorBS="gtaaacagggcttttgacccgcggagcatCCTTGttttttca agttcatTAGTGTAAACTTGTAATGGTttataaagttaaggtgctttttgggagggtt t" /listShort="mntR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2240116) /Source="Nicolas_upshifts" /id="U1907" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2459 /SigmaFactorBS="gtaaacagggcttttgacccgcggagcatCCTTGttttttca agttcatTAGTGTAAACTTGTAATGGTttataaagttaaggtgctttttgggagggtt t" /listShort="mntR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2240143..2240147) /Source="Nicolas_upshift_promotors" /id="U1907" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2459 /SigmaFactorBS="gtaaacagggcttttgacccgcggagcatCCTTGttttttca agttcatTAGTGTAAACTTGTAATGGTttataaagttaaggtgctttttgggagggtt t" /listShort="mntR" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2240173..2241009) /gene="lipM" /locus_tag="BSU_24530" /old_locus_tag="BSU24530" /EC_number="2.3.1.181" /function="3: Fatty acid and phospholipid metabolism" /experiment="publication(s) with functional evidences, PMID:20882995, 21338420, 21338421, 23960015" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20882995, 21338420, 21338421, 23960015; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein octanoyltransferase" /protein_id="NP_390333.1" /db_xref="EnsemblGenomes-Gn:BSU24530" /db_xref="EnsemblGenomes-Tr:CAB14384" /db_xref="GOA:P54511" /db_xref="InterPro:IPR004143" /db_xref="InterPro:IPR024898" /db_xref="SubtiList:BG11701" /db_xref="UniProtKB/Swiss-Prot:P54511" /translation="MQKETWRFIDSGNASPAFNMALDEALLYWHSEKKIPPVIRFYGW NPATLSVGYFQNIKKEINFEAVHKYNLGFVRRPTGGRGVLHDQELTYSVIVSEEHPEM PATVTEAYRVISEGILQGFRNLGLDAYFAIPRTEKEKESLKNPRSSVCFDAPSWYELV VEGRKVAGSAQTRQKGVILQHGSILLDLDEDKLFDLFLYPSERVRERMQRNFKNKAVA INELIEKRVTMDEARKAFKEGFETGLNIHLEPYELSQEELDFVHHLAETKYASDEWNY KR*" /label="lipM CDS" gene complement(2240173..2241009) /gene="lipM" /locus_tag="BSU_24530" /old_locus_tag="BSU24530" /label="lipM gene" promotor_-10 complement(2241033..2241052) /Source="Nicolas_upshift_promotors" /id="U1908" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.697302697302697" /psig="0.997002997002997" /xcortree=2353 /SigmaFactorBS="agcgtgattgtcatctataatggaactaaaaTATTTTTCatt ttcccgacagTTTGATAAACTGATTCTATTaaaacggtaaggaaggtcttaaaatgca a" /listShort="yqhM, mntR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2241044) /Source="Nicolas_upshifts" /id="U1908" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.697302697302697" /psig="0.997002997002997" /xcortree=2353 /SigmaFactorBS="agcgtgattgtcatctataatggaactaaaaTATTTTTCatt ttcccgacagTTTGATAAACTGATTCTATTaaaacggtaaggaaggtcttaaaatgca a" /listShort="yqhM, mntR" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2241046..2241590) /Source="Nicolas_S_feature" /locus_tag="new_2544841_2545385_c" /HighExp="Lbstat, LPhT, HiOs, M0t90, S1, M40t90, Sw, S0, B36, BC" /AntisenseName="yqhL" /AntisenseCor="-0.136624541005539" /AntisenseRegPval="-1.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S920" promotor_-35 complement(2241066..2241073) /Source="Nicolas_upshift_promotors" /id="U1908" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.697302697302697" /psig="0.997002997002997" /xcortree=2353 /SigmaFactorBS="agcgtgattgtcatctataatggaactaaaaTATTTTTCatt ttcccgacagTTTGATAAACTGATTCTATTaaaacggtaaggaaggtcttaaaatgca a" /listShort="yqhM, mntR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2241090..2241095 /Source="Nicolas_upshift_promotors" /id="U1909" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.458541458541459" /psig=1 /xcortree=2522 /SigmaFactorBS="caaactgtcgggaaaatgaaaaatattttagttccattataG ATGACaatcacgctgtgcTTTACTATAATAGTATTTGTcgaaaacggctctatgacct t" /listShort="S921, yqhL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2241109..2241128 /Source="Nicolas_upshift_promotors" /id="U1909" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.458541458541459" /psig=1 /xcortree=2522 /SigmaFactorBS="caaactgtcgggaaaatgaaaaatattttagttccattataG ATGACaatcacgctgtgcTTTACTATAATAGTATTTGTcgaaaacggctctatgacct t" /listShort="S921, yqhL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2241109 /Source="Nicolas_upshifts" /id="U1909" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.458541458541459" /psig=1 /xcortree=2522 /SigmaFactorBS="caaactgtcgggaaaatgaaaaatattttagttccattataG ATGACaatcacgctgtgcTTTACTATAATAGTATTTGTcgaaaacggctctatgacct t" /listShort="S921, yqhL" /GFF_Attribute="listLong" /label="upshifts" S_feature 2241120..2241199 /Source="Nicolas_S_feature" /locus_tag="new_2544915_2544994" /HighExp="dia15, H2O2, dia5, Diami, MG-0.2, G180, UNK1, LBGexp, Heat, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S921" CDS 2241200..2241580 /gene="yqhL" /locus_tag="BSU_24540" /old_locus_tag="BSU24540" /function="5.5: Sulfur metabolism" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11092948; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sulfur transferase" /protein_id="NP_390334.2" /db_xref="EnsemblGenomes-Gn:BSU24540" /db_xref="EnsemblGenomes-Tr:CAB14385" /db_xref="GOA:P54510" /db_xref="InterPro:IPR001763" /db_xref="InterPro:IPR036873" /db_xref="SubtiList:BG11700" /db_xref="UniProtKB/Swiss-Prot:P54510" /translation="MSNMIVLIIFAAFIIYMIASYVYQQRIMKTLTEEEFRAGYRKAQ LIDVREPNEFEGGHILGARNIPLSQLKQRKNEIRTDKPVYLYCQNSVRSGRAAQTLRK NGCTEIYNLKGGFKKWGGKIKAKK*" /label="yqhL CDS" gene 2241200..2241580 /gene="yqhL" /locus_tag="BSU_24540" /old_locus_tag="BSU24540" /label="yqhL gene" downshifts 2241516 /Source="Nicolas_upshifts" /id="D1274" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="6.17088" /MaxDrop="3.92673" /score="27.1863605" /energy="-12" /TU="U1909" /idTUdmin="U1909" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" downshifts 2241560 /Source="Nicolas_upshifts" /id="D1275" /incds=0 /nref=213 /ntot=249 /MaxReadThrough="2.26861" /MaxDrop="6.03848" /score="27.1863605" /energy="-12" /TU="NA" /idTUdmin="U1909" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2241615..2243081) /gene="gcvPB" /locus_tag="BSU_24550" /old_locus_tag="BSU24550" /EC_number="1.4.4.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8181752, 20011599, 22720735, 23721735, 29089431" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8181752, 20011599, 22720735, 23721735, 29089431; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycine decarboxylase (subunit 2) (glycine cleavage system protein P)" /protein_id="NP_390335.1" /db_xref="EnsemblGenomes-Gn:BSU24550" /db_xref="EnsemblGenomes-Tr:CAB14386" /db_xref="GOA:P54377" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR020581" /db_xref="InterPro:IPR023012" /db_xref="SubtiList:BG11511" /db_xref="UniProtKB/Swiss-Prot:P54377" /translation="MSNQDQALIFELSREGRIGYSLPELDVPEIELGDLLSDTYIRDE DAALPEVSELDIMRHYTALSKRNHGVDSGFYPLGSCTMKYNPKINEKIARIPGFAAIH PLQDEDTVQGALELLYDLSKHLEEITGMDEVTLQPAAGAHGEWTGLMMIRAYHEARGD FKRTKVIVPDSAHGTNPASATVAGFETVTVKSNEKGLVDLEDLKRAVNEETAALMLTN PNTLGLFEEQITEMAEIVHQAGGKLYYDGANLNAVLSKARPGDMGFDVVHLNLHKTFT GPHGGGGPGSGPVGVKQDLIPYLPKPVLVKKEGRFTFDYDRPHAIGRVKPYYGNFGIN VRAYTYIRSMGPDGLKAVTENAVLNANYMMRKLAPYYDLPFDRHCKHEFVLSGKRQKK LGVRTLDIAKRLLDFGYHPPTIYFPLNVEECIMIEPTETESKETLDAFIDAMIQIAKE AEENPELVQEAPHTTIVKRMDETKAARHPVLRYEAEER*" /label="gcvPB CDS" gene complement(2241615..2243081) /gene="gcvPB" /locus_tag="BSU_24550" /old_locus_tag="BSU24550" /label="gcvPB gene" downshifts complement(2241635) /Source="Nicolas_upshifts" /id="D1276" /incds=0 /nref=31 /ntot=215 /MaxReadThrough="3.45831" /MaxDrop="4.3142" /score="0.884126414" /energy="-12" /TU="U1911" /idTUdmin="U1911" /TUdmin="-1517" /isTUend="FALSE" /label="downshifts" CDS complement(2243074..2244420) /gene="gcvPA" /locus_tag="BSU_24560" /old_locus_tag="BSU24560" /EC_number="1.4.4.2" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8181752, 20011599, 23721735, 29089431; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycine decarboxylase (subunit 1) (glycine cleavage system protein P)" /protein_id="NP_390336.2" /db_xref="EnsemblGenomes-Gn:BSU24560" /db_xref="EnsemblGenomes-Tr:CAB14387" /db_xref="GOA:P54376" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR020581" /db_xref="InterPro:IPR023010" /db_xref="SubtiList:BG11510" /db_xref="UniProtKB/Swiss-Prot:P54376" /translation="MKHRYLPATEKDKQEMLATIGVSSIDDLFADIPENVKYKKEHQI KKAKSETELTRELTKLASKNRDTVQYASFLGAGVYDHYQPVIVDHVISRSEFYTAYTP YQPEISQGELQAIFEFQTMICELTGMDIANSSMYDGGTALAEAAMLASGHTKKKKIVV SKTVHPESREVLKTYAKGQYIDVVEVPAADGVTDLDALRQTVCENTAAVIVQYPNFFG RIEPLKDIEPIAHQGKSMFIVSANPLALGLLTPPGKFQSDIVVGDAQPFGIPSAYGGP HCGFFAVTKKLMRKVPGRLVGQTEDENGKRGFVLTLQAREQHIRRDKATSNICSNQAL NALAASVAMTALGKNGVKDIARQNLLKANYAKQEAKKAGLTVMFDGPMFNEFVIKLDE PVRAVNKRLLAKGMIGGYDLGLTYPELDCHMLIAVTELRTKEEIDALIQELGDRHE*" /label="gcvPA CDS" gene complement(2243074..2244420) /gene="gcvPA" /locus_tag="BSU_24560" /old_locus_tag="BSU24560" /label="gcvPA gene" CDS complement(2244450..2245538) /gene="gcvT" /locus_tag="BSU_24570" /old_locus_tag="BSU24570" /EC_number="2.1.2.10" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8219277, 15472076, 22720735, 23721735, 29089431" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8219277, 15472076, 22720735, 23721735, 29089431; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aminomethyltransferase (glycine cleavage system protein T)" /protein_id="NP_390337.2" /db_xref="EnsemblGenomes-Gn:BSU24570" /db_xref="EnsemblGenomes-Tr:CAB14388" /db_xref="GOA:P54378" /db_xref="InterPro:IPR006222" /db_xref="InterPro:IPR006223" /db_xref="InterPro:IPR013977" /db_xref="InterPro:IPR022903" /db_xref="InterPro:IPR028896" /db_xref="InterPro:IPR029043" /db_xref="PDB:1YX2" /db_xref="SubtiList:BG11509" /db_xref="UniProtKB/Swiss-Prot:P54378" /translation="MLKRTPLFDLYKEYGGKTIDFGGWELPVQFSSIKKEHEAVRTAA GLFDVSHMGEVEVSGNDSLSFLQRLMTNDVSALTPGRAQYTAMCYPDGGTVDDLLIYQ KGENRYLLVINASNIDKDLAWMKEHAAGDVQIDNQSDQIALLAVQGPKAEAILKNLTD ADVSALKPFAFIDEADISGRKALISRTGYTGEDGYEIYCRSDDAMHIWKKIIDAGDAY GLIPCGLGARDTLRFEAKLPLYGQELTRDITPIEAGIGFAVKHKKESDFFGKSVLSEQ KENGAKRKLVGLEMIEKGIPRHGYEVFQNGKSVGKVTTGTQSPTLGKNVGLALIDSET SEIGTVVDVEIRKKLVKAKVVKTPFYKR*" /label="gcvT CDS" gene complement(2244450..2245538) /gene="gcvT" /locus_tag="BSU_24570" /old_locus_tag="BSU24570" /label="gcvT gene" misc_RNA complement(2245612..2245811) /gene="swgA" /locus_tag="BSU_misc_RNA_37" /product="dual aptamer glycine riboswitch" /experiment="publication(s) with functional evidences, PMID:15472076, 21439473, 23249744, 23721735, 29089431" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15472076, 21439473, 23249744, 23721735, 29089431; Product type n: RNA" /label="swgA RNA" gene complement(2245612..2245811) /gene="swgA" /locus_tag="BSU_misc_RNA_37" /label="swgA gene" downshifts complement(2245662) /Source="Nicolas_upshifts" /id="D1277" /incds=0 /nref=1 /ntot=31 /MaxReadThrough="6.79606" /MaxDrop="3.0322" /score="21.5485037" /energy="-20.2" /TU="U1911" /idTUdmin="U1915" /TUdmin=3630 /isTUend="FALSE" /label="downshifts" S_feature complement(2245812..2245882) /Source="Nicolas_S_feature" /locus_tag="new_2549607_2549677_c" /HighExp="B60, S8, S6, B36, S7, M9-stat, Sw, T3.0H, HiOs, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S922" promotor_-35 2245815..2245820 /Source="Nicolas_upshift_promotors" /id="U1910" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.83016983016983" /psig="0.83016983016983" /xcortree=1074 /SigmaFactorBS="gttttcggtcaggtctctccccttgctgtcattcgCTCATAt tttcatgctgttatGGACATACTATAGCAATATcttacatcaaatacatactcatatc c" /listShort="S923, yqhH, yqhG, S924, sinI, sinR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2245836..2245854 /Source="Nicolas_upshift_promotors" /id="U1910" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.83016983016983" /psig="0.83016983016983" /xcortree=1074 /SigmaFactorBS="gttttcggtcaggtctctccccttgctgtcattcgCTCATAt tttcatgctgttatGGACATACTATAGCAATATcttacatcaaatacatactcatatc c" /listShort="S923, yqhH, yqhG, S924, sinI, sinR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2245840 /Source="Nicolas_upshifts" /id="U1910" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.83016983016983" /psig="0.83016983016983" /xcortree=1074 /SigmaFactorBS="gttttcggtcaggtctctccccttgctgtcattcgCTCATAt tttcatgctgttatGGACATACTATAGCAATATcttacatcaaatacatactcatatc c" /listShort="S923, yqhH, yqhG, S924, sinI, sinR" /GFF_Attribute="listLong" /label="upshifts" S_feature 2245850..2245979 /Source="Nicolas_S_feature" /locus_tag="new_2549645_2549774" /HighExp="S4, S8, S7, S3, S5, S6, LoTm, T5.0H, T4.0H, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.83" /TUlongSig="NA" /TUlongPSig="NA" /label="S923" promotor_-10 complement(2245868..2245887) /Source="Nicolas_upshift_promotors" /id="U1911" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.629370629370629" /psig="0.995004995004995" /xcortree=417 /SigmaFactorBS="gatgaataatataagaaaaatctgcccaaattgcTGTTGCCC agcatatagtgatGATGGTAGGATATGAGTATGtatttgatgtaagatattgctatag t" /listShort="S922, NA, NA, gcvT, gcvPA, gcvPB, S920, yqhM" /listLong="mntR" /label="promotor_-10" upshifts complement(2245882) /Source="Nicolas_upshifts" /id="U1911" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.629370629370629" /psig="0.995004995004995" /xcortree=417 /SigmaFactorBS="gatgaataatataagaaaaatctgcccaaattgcTGTTGCCC agcatatagtgatGATGGTAGGATATGAGTATGtatttgatgtaagatattgctatag t" /listShort="S922, NA, NA, gcvT, gcvPA, gcvPB, S920, yqhM" /listLong="mntR" /label="upshifts" promotor_-35 complement(2245901..2245908) /Source="Nicolas_upshift_promotors" /id="U1911" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.629370629370629" /psig="0.995004995004995" /xcortree=417 /SigmaFactorBS="gatgaataatataagaaaaatctgcccaaattgcTGTTGCCC agcatatagtgatGATGGTAGGATATGAGTATGtatttgatgtaagatattgctatag t" /listShort="S922, NA, NA, gcvT, gcvPA, gcvPB, S920, yqhM" /listLong="mntR" /label="promotor_-35" CDS 2245980..2247653 /gene="yqhH" /locus_tag="BSU_24580" /old_locus_tag="BSU24580" /EC_number="3.6.-.-" /function="16.3: Control" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 26735940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA polymerase-associated helicase protein" /protein_id="NP_390338.1" /db_xref="EnsemblGenomes-Gn:BSU24580" /db_xref="EnsemblGenomes-Tr:CAB14389" /db_xref="GOA:P54509" /db_xref="InterPro:IPR000330" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11699" /db_xref="UniProtKB/Swiss-Prot:P54509" /translation="MNTEMIYDAKWPEEFAERLKNDGPWANWELYKLSAEIQKTLAIP EFEGLRAPLYLPSFTPLPHQLEVAQKVVEKMNGKAILADEVGLGKTVEAGLILKEYMI RGLAKKILILVPASLVSQWVKELQEKFLIPAVEQKKSYVWEQCDIVVSSIDTAKRSPH REIVLSIPYDLVIIDEAHKLKNSKTKNYEFVRNLVKKYCLLLTATPIQNRIEEIFNLV SLLKPGHLGSQNHFQEEFAKKKSSLEAHEHLKDLVNKVMIRNRRHDTGLNWKQRHVET VPIQFSPSEQALYDEISRLKDSINKPASMFSIMTLQRECCSSREAVYMTLKKMLDQKE KQAPAIDEDTISVLIDRINQVTQNSKALQVVDLIKKIDDKVIIFTEYRATQIYLQWFL QQNGISSVPFRGGFKRGKKDWMKDLFRGKIQVLIATEAGGEGINLQFCNHMINYDLPW NPMRLEQRIGRIHRLGQERDVHIYNMATKHTVEEHILKLLYEKIHLFEKVVGELDDIL TKIQVNNFEEHLHDILYHSATEEEMKIKMDNLTSFLSYKKQLPAEKRGS*" /label="yqhH CDS" gene 2245980..2247653 /gene="yqhH" /locus_tag="BSU_24580" /old_locus_tag="BSU24580" /label="yqhH gene" CDS 2247674..2248468 /gene="yqhG" /locus_tag="BSU_24590" /old_locus_tag="BSU24590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390339.1" /db_xref="EnsemblGenomes-Gn:BSU24590" /db_xref="EnsemblGenomes-Tr:CAB14390" /db_xref="InterPro:IPR024562" /db_xref="SubtiList:BG11698" /db_xref="UniProtKB/Swiss-Prot:P54508" /translation="MRQQEVHDFLLRFFQANSCQIVDQGLGYMTVQLTVEMDKQIMNR PFYWHWREKTGGDPNPMKITFITDKENAPKDLDGEFIYFGAPRLFQIFKAVKQNGRFT RMYEKIESAGAKVPLQPWLGINVTISYQSDMKKDKLLSLGLHLVSGTIIEDFQSKLTQ FSLTSQICDYCFTISPMIKPESGLKRMENYISKSAMQEPSDWAEQAVNRWKNDMTLLD KFYEHIEEKPEEYHLEKQALKTLYQPKISVEIENGGLFYLQNNISS*" /label="yqhG CDS" gene 2247674..2248468 /gene="yqhG" /locus_tag="BSU_24590" /old_locus_tag="BSU24590" /label="yqhG gene" misc_feature 2248004..2248005 /Source="Nicolas_upshift_promotors" /id="U1912" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.497502497502497" /psig="0.541458541458541" /xcortree=3205 /SigmaFactorBS="aaagctgttaaacaaaatgggagatttaccagaatgtatgag aaaattgaatcaGCcggagctaaagtcccacttcagccttggcttggtataaatgtca c" /GFF_Attribute="listShort" /listLong="S924, sinI, sinR" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2248010 /Source="Nicolas_upshifts" /id="U1912" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.497502497502497" /psig="0.541458541458541" /xcortree=3205 /SigmaFactorBS="aaagctgttaaacaaaatgggagatttaccagaatgtatgag aaaattgaatcaGCcggagctaaagtcccacttcagccttggcttggtataaatgtca c" /GFF_Attribute="listShort" /listLong="S924, sinI, sinR" /label="upshifts" promotor_-35 2248492..2248495 /Source="Nicolas_upshift_promotors" /id="U1913" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.667332667332667" /psig="0.843156843156843" /xcortree=965 /SigmaFactorBS="ataatatttcaagctaacttttttaccattcgacatcattCT CGttttttttgagaaaaTACGATTATAATAAAGGTATattggaaaaaaattctggtga t" /listShort="S924, sinI, sinR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2248511..2248530 /Source="Nicolas_upshift_promotors" /id="U1913" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.667332667332667" /psig="0.843156843156843" /xcortree=965 /SigmaFactorBS="ataatatttcaagctaacttttttaccattcgacatcattCT CGttttttttgagaaaaTACGATTATAATAAAGGTATattggaaaaaaattctggtga t" /listShort="S924, sinI, sinR" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2248512..2248650 /Source="Nicolas_S_feature" /locus_tag="new_2552307_2552445" /HighExp="LoTm, S4, S5, T5.0H, M9-stat, S3, B60, S7, T4.0H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="0.843, 0.83" /TUlongSig="SigA" /TUlongPSig="0.541" /label="S924" upshifts 2248512 /Source="Nicolas_upshifts" /id="U1913" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.667332667332667" /psig="0.843156843156843" /xcortree=965 /SigmaFactorBS="ataatatttcaagctaacttttttaccattcgacatcattCT CGttttttttgagaaaaTACGATTATAATAAAGGTATattggaaaaaaattctggtga t" /listShort="S924, sinI, sinR" /GFF_Attribute="listLong" /label="upshifts" CDS 2248651..2248824 /gene="sinI" /locus_tag="BSU_24600" /old_locus_tag="BSU24600" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8549812, 10547280, 11751836, 15661000, 15805512, 23569226, 25326308, 26434553, 28430084" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8549812, 10547280, 11751836, 15661000, 15805512, 23569226, 25326308, 26434553, 28430084; Product type r: regulator" /codon_start=1 /transl_table=11 /product="antagonist of SinR" /protein_id="NP_390340.1" /db_xref="EnsemblGenomes-Gn:BSU24600" /db_xref="EnsemblGenomes-Tr:CAB14391" /db_xref="GOA:P23308" /db_xref="InterPro:IPR010981" /db_xref="InterPro:IPR036281" /db_xref="PDB:1B0N" /db_xref="SubtiList:BG10753" /db_xref="UniProtKB/Swiss-Prot:P23308" /translation="MKNAKQEHFELDQEWVELMVEAKEANISPEEIRKYLLLNKKSAH PGPAARSHTVNPF*" /label="sinI CDS" gene 2248651..2248824 /gene="sinI" /locus_tag="BSU_24600" /old_locus_tag="BSU24600" /label="sinI gene" promotor_-35 2248809..2248813 /Source="Nicolas_upshift_promotors" /id="U1914" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=3096 /SigmaFactorBS="acaaaaagtctgctcatcctggtccggcagccagaagtcata cCGTAAatcctttctgaaTGTGCTATAATATCACAAGGaaggtgatgacattgattgg c" /listShort="sinR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2248826..2248845 /Source="Nicolas_upshift_promotors" /id="U1914" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=3096 /SigmaFactorBS="acaaaaagtctgctcatcctggtccggcagccagaagtcata cCGTAAatcctttctgaaTGTGCTATAATATCACAAGGaaggtgatgacattgattgg c" /listShort="sinR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2248826 /Source="Nicolas_upshifts" /id="U1914" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=3096 /SigmaFactorBS="acaaaaagtctgctcatcctggtccggcagccagaagtcata cCGTAAatcctttctgaaTGTGCTATAATATCACAAGGaaggtgatgacattgattgg c" /listShort="sinR" /GFF_Attribute="listLong" /label="upshifts" CDS 2248858..2249193 /gene="sinR" /locus_tag="BSU_24610" /old_locus_tag="BSU24610" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15805512, 16585769, 16740951, 16923912, 21708175, 25326308, 26434553, 28546427" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15805512, 16585769, 16740951, 16923912, 21708175, 25326308, 26434553, 28546427; Product type r: regulator" /codon_start=1 /transl_table=11 /product="master regulator of biofilm formation" /protein_id="NP_390341.1" /db_xref="EnsemblGenomes-Gn:BSU24610" /db_xref="EnsemblGenomes-Tr:CAB14392" /db_xref="GOA:P06533" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010981" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR036281" /db_xref="PDB:1B0N" /db_xref="PDB:2YAL" /db_xref="PDB:3QQ6" /db_xref="PDB:3ZKC" /db_xref="SubtiList:BG10754" /db_xref="UniProtKB/Swiss-Prot:P06533" /translation="MIGQRIKQYRKEKGYSLSELAEKAGVAKSYLSSIERNLQTNPSI QFLEKVSAVLDVSVHTLLDEKHETEYDGQLDSEWEKLVRDAMTSGVSKKQFREFLDYQ KWRKSQKEE*" /label="sinR CDS" gene 2248858..2249193 /gene="sinR" /locus_tag="BSU_24610" /old_locus_tag="BSU24610" /label="sinR gene" downshifts 2249170 /Source="Nicolas_upshifts" /id="D1278" /incds=0 /nref=21 /ntot=181 /MaxReadThrough="4.7611" /MaxDrop="6.41889" /score="2.30357781" /energy="-20" /TU="U1913,U1914" /idTUdmin="U1910" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" downshifts 2249260 /Source="Nicolas_upshifts" /id="D1279" /incds=0 /nref=1 /ntot=85 /MaxReadThrough="2.4376" /MaxDrop="4.25363" /score="58.1462301" /energy="-26.8" /TU="NA" /idTUdmin="U1913" /TUdmin=22 /isTUend="TRUE" /label="downshifts" CDS complement(2249286..2250071) /gene="tasA" /locus_tag="BSU_24620" /old_locus_tag="BSU24620" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10464223, 10827084, 16430695, 16430696, 18047568, 23569226, 25326308, 27655338, 28546427" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10464223, 10827084, 16430695, 16430696, 18047568, 23569226, 25326308, 27655338, 28546427; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="major biofilm matrix component" /protein_id="NP_390342.1" /db_xref="EnsemblGenomes-Gn:BSU24620" /db_xref="EnsemblGenomes-Tr:CAB14393" /db_xref="GOA:P54507" /db_xref="InterPro:IPR022121" /db_xref="InterPro:IPR023833" /db_xref="SubtiList:BG11697" /db_xref="UniProtKB/Swiss-Prot:P54507" /translation="MGMKKKLSLGVASAALGLALVGGGTWAAFNDIKSKDATFASGTL DLSAKENSASVNLSNLKPGDKLTKDFQFENNGSLAIKEVLMALNYGDFKANGGSNTSP EDFLSQFEVTLLTVGKEGGNGYPKNIILDDANLKDLYLMSAKNDAAAAEKIKKQIDPK FLNASGKVNVATIDGKTAPEYDGVPKTPTDFDQVQMEIQFKDDKTKDEKGLMVQNKYQ GNSIKLQFSFEATQWNGLTIKKDHTDKDGYVKENEKAHSEDKN*" /label="tasA CDS" gene complement(2249286..2250071) /gene="tasA" /locus_tag="BSU_24620" /old_locus_tag="BSU24620" /label="tasA gene" downshifts complement(2249292) /Source="Nicolas_upshifts" /id="D1280" /incds=0 /nref=144 /ntot=227 /MaxReadThrough="4.33009" /MaxDrop="8.70948" /score="10.0483516" /energy="-20" /TU="NA" /idTUdmin="U1915" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(2250124..2250141) /Source="Nicolas_upshift_promotors" /id="U1915" /multdbtbs="-" /comp="M14" /sig="Sig-" /pcomp="0.236763236763237" /psig="0.478521478521479" /xcortree=2768 /SigmaFactorBS="agaaagacaaaagccttggaaacagatacaaaggacagcacc atgtcTACTTAACTTCAGTTGTAaacctggcaacaggtttcgatataaaatcattcaa t" /listShort="tasA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2250128) /Source="Nicolas_upshifts" /id="U1915" /multdbtbs="-" /comp="M14" /sig="Sig-" /pcomp="0.236763236763237" /psig="0.478521478521479" /xcortree=2768 /SigmaFactorBS="agaaagacaaaagccttggaaacagatacaaaggacagcacc atgtcTACTTAACTTCAGTTGTAaacctggcaacaggtttcgatataaaatcattcaa t" /listShort="tasA" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2250135..2250707) /gene="sipW" /locus_tag="BSU_24630" /old_locus_tag="BSU24630" /EC_number="3.4.21.89" /function="16.1: Circulate" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10464223, 10559173, 10827084, 15101989, 16430695, 22328672, 26346121, 27655338" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10464223, 10559173, 10827084, 15101989, 16430695, 22328672, 26346121, 27655338; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="type I signal peptidase" /protein_id="NP_390343.1" /db_xref="EnsemblGenomes-Gn:BSU24630" /db_xref="EnsemblGenomes-Tr:CAB14394" /db_xref="GOA:P54506" /db_xref="InterPro:IPR001733" /db_xref="InterPro:IPR015927" /db_xref="InterPro:IPR036286" /db_xref="SubtiList:BG11696" /db_xref="UniProtKB/Swiss-Prot:P54506" /translation="MKLISNILYVIIFTLIIVLTLVVISTRSSGGEPAVFGYTLKSVL SGSMEPEFNTGSLILVKEITDVKELQKGDVITFMQDANTAVTHRIVDITKQGDHLLFK TKGDNNAAADSAPVSDENVRAQYTGFQLPYAGYMLHFASQPIGTAVLLIVPGVMLLVY AFVTISSAIREIERKTKALETDTKDSTMST*" /label="sipW CDS" gene complement(2250135..2250707) /gene="sipW" /locus_tag="BSU_24630" /old_locus_tag="BSU24630" /label="sipW gene" CDS complement(2250691..2251452) /gene="tapA" /locus_tag="BSU_24640" /old_locus_tag="BSU24640" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10464223, 10559173, 14707086, 16430695, 17554552, 21477127, 24488317, 26441856, 26819068, 27655338" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10464223, 10559173, 14707086, 16430695, 17554552, 21477127, 24488317, 26441856, 26819068, 27655338; Product type lp : lipoprotein" /codon_start=1 /transl_table=11 /product="lipoprotein for biofilm formation" /protein_id="NP_390344.1" /db_xref="EnsemblGenomes-Gn:BSU24640" /db_xref="EnsemblGenomes-Tr:CAB14395" /db_xref="GOA:P40949" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR023833" /db_xref="InterPro:IPR023848" /db_xref="SubtiList:BG11076" /db_xref="UniProtKB/Swiss-Prot:P40949" /translation="MFRLFHNQQKAKTKLKVLLIFQLSVIFSLTAAICLQFSDDTSAA FHDIETFDVSLQTCKDFQHTDKNCHYDKRWDQSDLHISDQTDTKGTVCSPFALFAVLE NTGEKLKKSKWKWELHKLENARKPLKDGNVIEKGFVSNQIGDSLYKIETKKKMKPGIY AFKVYKPAGYPANGSTFEWSEPMRLAKCDEKPTVPKKETKSDVKKENETTQKDIPEKT MKEETSQEAVTKEKETQSDQKESGEEDEKSNEADQ*" /label="tapA CDS" gene complement(2250691..2251452) /gene="tapA" /locus_tag="BSU_24640" /old_locus_tag="BSU24640" /label="tapA gene" promotor_-10 complement(2251512..2251531) /Source="Nicolas_upshift_promotors" /id="U1916" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig="0.97002997002997" /xcortree=2769 /SigmaFactorBS="aaaacattcttttaaacgaacaaaatgagcgatttcggTGTT TTTAaatctataaatcgTTGATTATACTCTATTTGTGaagttctttaaagagaacgat t" /listShort="yqxM, sipW" /listLong="tasA" /label="promotor_-10" upshifts complement(2251530) /Source="Nicolas_upshifts" /id="U1916" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig="0.97002997002997" /xcortree=2769 /SigmaFactorBS="aaaacattcttttaaacgaacaaaatgagcgatttcggTGTT TTTAaatctataaatcgTTGATTATACTCTATTTGTGaagttctttaaagagaacgat t" /listShort="yqxM, sipW" /listLong="tasA" /label="upshifts" promotor_-35 complement(2251545..2251552) /Source="Nicolas_upshift_promotors" /id="U1916" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig="0.97002997002997" /xcortree=2769 /SigmaFactorBS="aaaacattcttttaaacgaacaaaatgagcgatttcggTGTT TTTAaatctataaatcgTTGATTATACTCTATTTGTGaagttctttaaagagaacgat t" /listShort="yqxM, sipW" /listLong="tasA" /label="promotor_-35" promotor_-35 2251674..2251680 /Source="Nicolas_upshift_promotors" /id="U1917" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1137 /SigmaFactorBS="ctcattttttcaattttttagaaatttttgggattgttatgt gagaatttaaaTGCATATcccattattatttGGTAATAATAAAcaaagaaagggtgac a" /listShort="yqzG" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2251681 /Source="Nicolas_upshifts" /id="U1917" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1137 /SigmaFactorBS="ctcattttttcaattttttagaaatttttgggattgttatgt gagaatttaaaTGCATATcccattattatttGGTAATAATAAAcaaagaaagggtgac a" /listShort="yqzG" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2251694..2251705 /Source="Nicolas_upshift_promotors" /id="U1917" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1137 /SigmaFactorBS="ctcattttttcaattttttagaaatttttgggattgttatgt gagaatttaaaTGCATATcccattattatttGGTAATAATAAAcaaagaaagggtgac a" /listShort="yqzG" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2251724..2252050 /gene="yqzG" /locus_tag="BSU_24650" /old_locus_tag="BSU24650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_390345.1" /db_xref="EnsemblGenomes-Gn:BSU24650" /db_xref="EnsemblGenomes-Tr:CAB14396" /db_xref="InterPro:IPR024987" /db_xref="PDB:2LYX" /db_xref="SubtiList:BG13773" /db_xref="UniProtKB/Swiss-Prot:O32019" /translation="MMIKQCVICLSLLVFGTTAAHAEETPLVTARHMSKWEEIAVKEA KKRYPLAQVLFKQKVWDRKRKDEAVKQYHLTLREGSKEFGVFVTISFDPYSQKVNKIA ILEEYQ*" /label="yqzG CDS" gene 2251724..2252050 /gene="yqzG" /locus_tag="BSU_24650" /old_locus_tag="BSU24650" /label="yqzG gene" S_feature complement(2251867..2252091) /Source="Nicolas_S_feature" /locus_tag="new_2555662_2555886_c" /HighExp="GM 150, G/S, C30, T-4.40H, S8, T-3.40H, Pyr, S7, S2, C90" /AntisenseName="yqzG" /AntisenseCor="0.536702817178903" /AntisenseRegPval="-20.7" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="0.549, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S925" downshifts complement(2251910) /Source="Nicolas_upshifts" /id="D1281" /incds=1 /nref=92 /ntot=160 /MaxReadThrough="2.23218" /MaxDrop="5.56661" /score="31.27773" /energy="-10.2" /TU="NA" /idTUdmin="U1918" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 2252032 /Source="Nicolas_upshifts" /id="D1282" /incds=0 /nref=13 /ntot=41 /MaxReadThrough="2.14107" /MaxDrop="4.98052" /score="-9.62570043" /energy="-15.1" /TU="NA" /idTUdmin="U1917" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2252092..2252271) /gene="spoIIT" /locus_tag="BSU_24660" /old_locus_tag="BSU24660" /function="16.1: Circulate" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 26735940; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="factor involved in sporulation" /protein_id="NP_390346.2" /db_xref="EnsemblGenomes-Gn:BSU24660" /db_xref="EnsemblGenomes-Tr:CAB14397" /db_xref="InterPro:IPR025622" /db_xref="SubtiList:BG13771" /db_xref="UniProtKB/Swiss-Prot:O32020" /translation="MKTNDYVKYMTQQFVKYIDTPRDERKERKEVRKETKTPVSQQWF GILPYGFRLWLKRKK*" /label="spoIIT CDS" gene complement(2252092..2252271) /gene="spoIIT" /locus_tag="BSU_24660" /old_locus_tag="BSU24660" /label="spoIIT gene" promotor_-10 complement(2252290..2252308) /Source="Nicolas_upshift_promotors" /id="U1918" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.549450549450549" /psig="0.549450549450549" /xcortree=1011 /SigmaFactorBS="aaactgctgagatggacagaataaaacagtgtaaagGGTATA AaaaaagtcatgtgaGACAACACTCATAATAATTgaatgatgaggtgatcacgtgaaa a" /listShort="yqzE, S925" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2252305) /Source="Nicolas_upshifts" /id="U1918" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.549450549450549" /psig="0.549450549450549" /xcortree=1011 /SigmaFactorBS="aaactgctgagatggacagaataaaacagtgtaaagGGTATA AaaaaagtcatgtgaGACAACACTCATAATAATTgaatgatgaggtgatcacgtgaaa a" /listShort="yqzE, S925" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2252323..2252329) /Source="Nicolas_upshift_promotors" /id="U1918" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.549450549450549" /psig="0.549450549450549" /xcortree=1011 /SigmaFactorBS="aaactgctgagatggacagaataaaacagtgtaaagGGTATA AaaaaagtcatgtgaGACAACACTCATAATAATTgaatgatgaggtgatcacgtgaaa a" /listShort="yqzE, S925" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2252342..2252716) /gene="comGG" /locus_tag="BSU_24670" /old_locus_tag="BSU24670" /function="16.5: Explore" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9150204, 9723928, 15849754, 16850406, 24164455" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9150204, 9723928, 15849754, 16850406, 24164455; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="component of the DNA transport pilin platform" /protein_id="NP_390347.1" /db_xref="EnsemblGenomes-Gn:BSU24670" /db_xref="EnsemblGenomes-Tr:CAB14398" /db_xref="GOA:P25959" /db_xref="InterPro:IPR020372" /db_xref="SubtiList:BG10489" /db_xref="UniProtKB/Swiss-Prot:P25959" /translation="MYRTRGFIYPAVLFVSALVLLIVNFVAAQYISRCMFEKETKELY IGENLLQNGVLLSIRHVLEERKGQEGTQQFLYGRVSYYIHDTSIKEQKEINLRVSTDS GTERTAQIVFDQKQKKLLRWTE*" /label="comGG CDS" gene complement(2252342..2252716) /gene="comGG" /locus_tag="BSU_24670" /old_locus_tag="BSU24670" /label="comGG gene" CDS complement(2252717..2253100) /gene="comGF" /locus_tag="BSU_24680" /old_locus_tag="BSU24680" /function="16.5: Explore" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9150204, 9723928, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9150204, 9723928, 15849754, 16850406; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="component of the DNA transport pilin platform" /protein_id="NP_390348.1" /db_xref="EnsemblGenomes-Gn:BSU24680" /db_xref="EnsemblGenomes-Tr:CAB14399" /db_xref="GOA:P25958" /db_xref="InterPro:IPR016977" /db_xref="SubtiList:BG10488" /db_xref="UniProtKB/Swiss-Prot:P25958" /translation="MLISGSLAAIIHLFLSRQQEHDGFTQQEWMISIEQMMNECKESQ AVKTAEHGSVLICTNLSGQDIRFDIYHSMIRKRVDGKGHVPILDHITAMKADIENGVV LLKIESEDQKVYQTAFPVYSYLGGG*" /label="comGF CDS" gene complement(2252717..2253100) /gene="comGF" /locus_tag="BSU_24680" /old_locus_tag="BSU24680" /label="comGF gene" CDS complement(2253126..2253473) /gene="comGE" /locus_tag="BSU_24690" /old_locus_tag="BSU24690" /function="16.11: Scavenge (Catabolism)" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:7783624, 9224890, 9422590, 9723928, 16751195" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7783624, 9224890, 9422590, 9723928, 16751195; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="component of the DNA transport pilin platform" /protein_id="NP_390349.1" /db_xref="EnsemblGenomes-Gn:BSU24690" /db_xref="EnsemblGenomes-Tr:CAB14400" /db_xref="GOA:P25957" /db_xref="InterPro:IPR012902" /db_xref="InterPro:IPR020488" /db_xref="SubtiList:BG10487" /db_xref="UniProtKB/Swiss-Prot:P25957" /translation="MWRENKGFSTIETMSALSLWLFVLLTVVPLWDKLMADEKMAESR EIGYQMMNESISKYVMSGEGAASKTITKNNHIYAMKWEEEGEYQNVCIKAAAYKEKSF CLSILQTEWLHAS*" /label="comGE CDS" gene complement(2253126..2253473) /gene="comGE" /locus_tag="BSU_24690" /old_locus_tag="BSU24690" /label="comGE gene" CDS complement(2253457..2253888) /gene="comGD" /locus_tag="BSU_24700" /old_locus_tag="BSU24700" /function="16.5: Explore" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9224890, 9422590, 9723928, 16751195" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9224890, 9422590, 9723928, 16751195; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="membrane component of the DNA transport pilin platform" /protein_id="NP_390350.1" /db_xref="EnsemblGenomes-Gn:BSU24700" /db_xref="EnsemblGenomes-Tr:CAB14401" /db_xref="GOA:P25956" /db_xref="InterPro:IPR002416" /db_xref="InterPro:IPR012902" /db_xref="InterPro:IPR016785" /db_xref="SubtiList:BG10486" /db_xref="UniProtKB/Swiss-Prot:P25956" /translation="MNIKLNEEKGFTLLESLLVLSLASILLVAVFTTLPPAYDNTAVR QAASQLKNDIMLTQQTAISRQQRTKILFHKKEYQLVIGDTVIERPYATGLSIELLTLK DRLEFNEKGHPNAGGKIRVKGHAVYDITVYLGSGRVNVERK*" /label="comGD CDS" gene complement(2253457..2253888) /gene="comGD" /locus_tag="BSU_24700" /old_locus_tag="BSU24700" /label="comGD gene" CDS complement(2253878..2254174) /gene="comGC" /locus_tag="BSU_24710" /old_locus_tag="BSU24710" /function="16.11: Scavenge (Catabolism)" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:7783624, 9723928, 11744713, 16751195, 22820325, 24164455, 28659339" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7783624, 9723928, 11744713, 16751195, 22820325, 24164455, 28659339; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="pilin-like component of the DNA transport membrane pilin platform" /protein_id="NP_390351.1" /db_xref="EnsemblGenomes-Gn:BSU24710" /db_xref="EnsemblGenomes-Tr:CAB14402" /db_xref="GOA:P25955" /db_xref="InterPro:IPR012902" /db_xref="InterPro:IPR016940" /db_xref="SubtiList:BG10485" /db_xref="UniProtKB/Swiss-Prot:P25955" /translation="MNEKGFTLVEMLIVLFIISILLLITIPNVTKHNQTIQKKGCEGL QNMVKAQMTAFELDHEGQTPSLADLQSEGYVKKDAVCPNGKRIIITGGEVKVEH*" /label="comGC CDS" gene complement(2253878..2254174) /gene="comGC" /locus_tag="BSU_24710" /old_locus_tag="BSU24710" /label="comGC gene" CDS complement(2254188..2255159) /gene="comGB" /locus_tag="BSU_24720" /old_locus_tag="BSU24720" /function="16.11: Scavenge (Catabolism)" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9150204, 9723928, 15849754, 15968048, 16850406, 24164455" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9150204, 9723928, 15849754, 15968048, 16850406, 24164455; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="membrane pilin platform component of the DNA transport machinery" /protein_id="NP_390352.1" /db_xref="EnsemblGenomes-Gn:BSU24720" /db_xref="EnsemblGenomes-Tr:CAB14403" /db_xref="GOA:P25954" /db_xref="InterPro:IPR001992" /db_xref="InterPro:IPR018076" /db_xref="SubtiList:BG10484" /db_xref="UniProtKB/Swiss-Prot:P25954" /translation="MTAGGYTLLDGLRLMELQMNKRQAADLTDSVTCLREGAPFYQVL KSLSFHKEAVGICYFAETHGELPASMIQSGELLERKIAQADQLKRVLRYPLFLIFTVA VMFYMLQSIIIPQFSGIYQSMNMETSRSTDMLFAFFQHIDLVIILLVLFTAGIGIYYW LVFKKKSPARQMLICIRIPLVGKLVKLFNSYFFSLQLSSLLKSGLSIYDSLNAFKHQT FLPFYRCEAEQLIERLKAGESIESAICGSLFYETDLSKVISHGQLSGRLDRELFTYSQ FILQRLEHKAQKWTGILQPMIYGFVAAMILLVYLSMLVPMYQMMNQM*" /label="comGB CDS" gene complement(2254188..2255159) /gene="comGB" /locus_tag="BSU_24720" /old_locus_tag="BSU24720" /label="comGB gene" CDS complement(2255212..2256282) /gene="comGA" /locus_tag="BSU_24730" /old_locus_tag="BSU24730" /function="16.5: Explore" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11298275, 15528548, 16009134, 9723928, 21564336, 21707789, 25899641" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11298275, 15528548, 16009134, 9723928, 21564336, 21707789, 25899641; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="membrane associated ATPase of the pilin platformfor DNA competence" /protein_id="NP_390353.1" /db_xref="EnsemblGenomes-Gn:BSU24730" /db_xref="EnsemblGenomes-Tr:CAB14404" /db_xref="GOA:P25953" /db_xref="InterPro:IPR001482" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10483" /db_xref="UniProtKB/Swiss-Prot:P25953" /translation="MDSIEKVSKNLIEEAYLTKASDIHIVPRERDAIIHFRVDHALLK KRDMKKEECVRLISHFKFLSAMDIGERRKPQNGSLTLKLKEGNVHLRMSTLPTINEES LVIRVMPQYNIPSIDKLSLFPKTGATLLSFLKHSHGMLIFTGPTGSGKTTTLYSLVQY AKKHFNRNIVTLEDPVETRDEDVLQVQVNEKAGVTYSAGLKAILRHDPDMIILGEIRD AETAEIAVRAAMTGHLVLTSLHTRDAKGAIYRLLEFGINMNEIEQTVIAIAAQRLVDL ACPFCENGCSSVYCRQSRNTRRASVYELLYGKNLQQCIQEAKGNHANYQYQTLRQIIR KGIALGYLTTNNYDRWVYHEKD*" /label="comGA CDS" gene complement(2255212..2256282) /gene="comGA" /locus_tag="BSU_24730" /old_locus_tag="BSU24730" /label="comGA gene" promotor_-10 complement(2256300..2256319) /Source="Nicolas_upshift_promotors" /id="U1919" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2966 /SigmaFactorBS="ttcagcatataacatctcacaaaatcacgttttcccTGTTTG ATtaccttttcttctTTTTCTACAATATGCGTTGAaaggagagggaatcaaattggat t" /listShort="comGA, comGB, comGC, comGD, comGE, comGF, comGG, yqzE, S925" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2256316) /Source="Nicolas_upshifts" /id="U1919" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2966 /SigmaFactorBS="ttcagcatataacatctcacaaaatcacgttttcccTGTTTG ATtaccttttcttctTTTTCTACAATATGCGTTGAaaggagagggaatcaaattggat t" /listShort="comGA, comGB, comGC, comGD, comGE, comGF, comGG, yqzE, S925" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2256333..2256340) /Source="Nicolas_upshift_promotors" /id="U1919" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.943056943056943" /psig=1 /xcortree=2966 /SigmaFactorBS="ttcagcatataacatctcacaaaatcacgttttcccTGTTTG ATtaccttttcttctTTTTCTACAATATGCGTTGAaaggagagggaatcaaattggat t" /listShort="comGA, comGB, comGC, comGD, comGE, comGF, comGG, yqzE, S925" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2256465..2256693) /Source="Nicolas_S_feature" /locus_tag="new_2560260_2560488_c" /HighExp="Etha, Salt, Sw, Gly, LPhT, B36, Heat, B60, LoTm, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.37350499999999998" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S926" downshifts complement(2256506) /Source="Nicolas_upshifts" /id="D1283" /incds=0 /nref=16 /ntot=42 /MaxReadThrough="0.95925" /MaxDrop="5.92871" /score="30.7083619" /energy="-13" /TU="NA" /idTUdmin="U1920" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(2256694..2257647) /gene="yqxL" /locus_tag="BSU_24740" /old_locus_tag="BSU24740" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15856219, 24415722" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15856219, 24415722; Product type t: transporter" /codon_start=1 /transl_table=11 /product="CorA-type divalent ion transporter" /protein_id="NP_390354.1" /db_xref="EnsemblGenomes-Gn:BSU24740" /db_xref="EnsemblGenomes-Tr:CAB14405" /db_xref="GOA:P40948" /db_xref="InterPro:IPR002523" /db_xref="SubtiList:BG11075" /db_xref="UniProtKB/Swiss-Prot:P40948" /translation="MKAHTGKDWFWYQMGPQERSKARDLIHFSHWPQCEKWFENNHHV NFLRVDTTETENEAVFGSIVYDQGLGEEKDHTVFHFYITRQYFFTINFDFSILREIKG KEVVRQMERADNAIEGFLILLGELMNAYLIGVDEFEVKLRKLRWQIKDDNSKSILNRV HLLRHELMIWKNLILSAKKIEMALKETFLPQNEGKKDYQRTQLKIDRGFTYISEFEGE LNNLLHSEEVITSHRGNEIVKALTIFTTLFTPITALGALWGMNFSVMPELNWKYGYLF SLLLIVTSTVLIYLYLRKKGWTGDMLQERKKKKKPRKRRTL*" /label="yqxL CDS" gene complement(2256694..2257647) /gene="yqxL" /locus_tag="BSU_24740" /old_locus_tag="BSU24740" /label="yqxL gene" promotor_-10 complement(2257671..2257690) /Source="Nicolas_upshift_promotors" /id="U1920" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=239 /SigmaFactorBS="cacctgaaaatgctcataaaacatgtgttgaagcggcagact GGTTTAGtgacgcggttattGGGCAATTAAAGAATAAAGAacaaaagtttggaggagc t" /listShort="yqxL, S926" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2257692) /Source="Nicolas_upshifts" /id="U1920" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=239 /SigmaFactorBS="cacctgaaaatgctcataaaacatgtgttgaagcggcagact GGTTTAGtgacgcggttattGGGCAATTAAAGAATAAAGAacaaaagtttggaggagc t" /listShort="yqxL, S926" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2257704..2257710) /Source="Nicolas_upshift_promotors" /id="U1920" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=239 /SigmaFactorBS="cacctgaaaatgctcataaaacatgtgttgaagcggcagact GGTTTAGtgacgcggttattGGGCAATTAAAGAATAAAGAacaaaagtttggaggagc t" /listShort="yqxL, S926" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2257730..2257736 /Source="Nicolas_upshift_promotors" /id="U1921" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=246 /SigmaFactorBS="ccagtctgccgcttcaacacaTGTTTTAtgagcattttcagg TGGTATGGAATGTAGAAAGacatcggaaaagggaggtgcatgccttccttggagaagg c" /listShort="yqhB, S927" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2257751..2257769 /Source="Nicolas_upshift_promotors" /id="U1921" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=246 /SigmaFactorBS="ccagtctgccgcttcaacacaTGTTTTAtgagcattttcagg TGGTATGGAATGTAGAAAGacatcggaaaagggaggtgcatgccttccttggagaagg c" /listShort="yqhB, S927" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2257769 /Source="Nicolas_upshifts" /id="U1921" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=246 /SigmaFactorBS="ccagtctgccgcttcaacacaTGTTTTAtgagcattttcagg TGGTATGGAATGTAGAAAGacatcggaaaagggaggtgcatgccttccttggagaagg c" /listShort="yqhB, S927" /GFF_Attribute="listLong" /label="upshifts" CDS 2257790..2259118 /gene="yqhB" /locus_tag="BSU_24750" /old_locus_tag="BSU24750" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane associated enzyme" /protein_id="NP_390355.1" /db_xref="EnsemblGenomes-Gn:BSU24750" /db_xref="EnsemblGenomes-Tr:CAB14406" /db_xref="GOA:P54505" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR002550" /db_xref="InterPro:IPR005170" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR036318" /db_xref="SubtiList:BG11695" /db_xref="UniProtKB/Swiss-Prot:P54505" /translation="MPSLEKAVVLEFINLLAVAILILLTGFFVAVEFSIVKVRRSKID QLVAKGKKGAKAAKHVITHLDEYLSACQLGITVAALGLGWLGEPTVQTLLRPLFHKAG LNESLTHLLSLVIAFLVVTYLNVVIGELAPKSFAIQKAESITLLFAKPLIWFYKIMFP FIWLLNHSARLITGVFGLKPASEHELAYTEEELRVLLAESYKSGEIRKSELKYMNNIF TFDKRMAKEIMVPRNEMVSLSLDEDSISNLQETVKQTKYTRYPVVREDKDNVIGVINM KEVLFSMLTKDFSIKKHQIEPFVQPVIHVIETIPIYKLLLKMQKERTHMAILIDEYGG TSGLVTVEDIIEEIVGEIRDEFDADEVPHIRELGKDHYLLNAKLLISDVNSLLGTDLS EAEVDTLGGWFLTQNIDAEPESAIEYDGYSFKVKDINSHHILFIEVKKAE*" /label="yqhB CDS" gene 2257790..2259118 /gene="yqhB" /locus_tag="BSU_24750" /old_locus_tag="BSU24750" /label="yqhB gene" S_feature 2259119..2260093 /Source="Nicolas_S_feature" /locus_tag="new_2562914_2563888" /HighExp="Sw, Salt, Etha, LPhT, M9-stat, S8, BC, S6, BT, Gly" /AntisenseName="rsbRD" /AntisenseCor="0.58358076577781004" /AntisenseRegPval="-25.2" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S927" CDS complement(2259171..2260007) /gene="rsbRD" /locus_tag="BSU_24760" /old_locus_tag="BSU24760" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11157946, 15312768, 15583165, 16963570, 17158665" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11157946, 15312768, 15583165, 16963570, 17158665; Product type f: factor" /codon_start=1 /transl_table=11 /product="component of the anxiosome (stressosome)" /protein_id="NP_390356.2" /db_xref="EnsemblGenomes-Gn:BSU24760" /db_xref="EnsemblGenomes-Tr:CAB14407" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR025751" /db_xref="InterPro:IPR036513" /db_xref="SubtiList:BG11694" /db_xref="UniProtKB/Swiss-Prot:P54504" /translation="MIALDQHLTEHKKDITQQWLEVCTSNGSWLYSAKDQQKLEQKLK DQHELLVTIVAKSLRKEDVEDELNRWSLQCARDRAVHEVTVTQSVGQFNTFRHIMFEW IHKFSEASSQDISIQEFYEWSRILNQNIDEIIEVFTEEYHQVTMIQLNAQKEMINELS APIMPITDGIGILPLVGEIDTHRARTILESVLEQCSALKLSYLFLDISGVPIVDTMVA YQIFKVIDSTKLLGIETIISGIRPEIAQTVVKLGLDFSNVKTEQSLAKALANKGFKIK EC*" /label="rsbRD CDS" gene complement(2259171..2260007) /gene="rsbRD" /locus_tag="BSU_24760" /old_locus_tag="BSU24760" /label="rsbRD gene" S_feature complement(2260008..2260192) /Source="Nicolas_S_feature" /locus_tag="new_2563803_2563987_c" /HighExp="Etha, LoTm, Salt, Heat, Gly, M9-stat, B60, S8, S0, Mal" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.147982" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S928" tRNA 2260094..2260164 /gene="trnSL-Gln1" /locus_tag="BSU_tRNA_73" /product="tRNA-Gln" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Gln (UUG); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /label="trnSL-Gln1 tRNA" gene 2260094..2260164 /gene="trnSL-Gln1" /locus_tag="BSU_tRNA_73" /label="trnSL-Gln1 gene" CDS complement(2260231..2260611) /gene="mgsR" /locus_tag="BSU_24770" /old_locus_tag="BSU24770" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:18643936, 22812682" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18643936, 22812682; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of stress" /protein_id="NP_390357.2" /db_xref="EnsemblGenomes-Gn:BSU24770" /db_xref="EnsemblGenomes-Tr:CAB14408" /db_xref="GOA:P54503" /db_xref="InterPro:IPR006504" /db_xref="InterPro:IPR006660" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG11693" /db_xref="UniProtKB/Swiss-Prot:P54503" /translation="MEQQLTFYSYPSCTSCRKTKHWLKAHQIEFNERHLFRETPTREE LKYILSLTTEGIDEILATRSQTFKNLNLNIEEMTVNEVLELLIEKPKLLRRPILVDNK KLVIGYNPGELLKLSKKKTVHQSA*" /label="mgsR CDS" gene complement(2260231..2260611) /gene="mgsR" /locus_tag="BSU_24770" /old_locus_tag="BSU24770" /label="mgsR gene" downshifts complement(2260237) /Source="Nicolas_upshifts" /id="D1284" /incds=0 /nref=9 /ntot=174 /MaxReadThrough="6.12556" /MaxDrop="6.72616" /score="0.164931099" /energy="-19.7" /TU="U1922" /idTUdmin="U1925" /TUdmin=912 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2260640..2260658) /Source="Nicolas_upshift_promotors" /id="U1922" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=225 /SigmaFactorBS="aatgttttttaaaaaataatccgaaaaaagttctgtaaatGG TTTAAatgaaaaatgatccGGGTAGTTATTCTACAAAGagatggttaactgaggagga a" /listShort="mgsR, S928, rsbRD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2260659) /Source="Nicolas_upshifts" /id="U1922" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=225 /SigmaFactorBS="aatgttttttaaaaaataatccgaaaaaagttctgtaaatGG TTTAAatgaaaaatgatccGGGTAGTTATTCTACAAAGagatggttaactgaggagga a" /listShort="mgsR, S928, rsbRD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2260673..2260679) /Source="Nicolas_upshift_promotors" /id="U1922" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=225 /SigmaFactorBS="aatgttttttaaaaaataatccgaaaaaagttctgtaaatGG TTTAAatgaaaaatgatccGGGTAGTTATTCTACAAAGagatggttaactgaggagga a" /listShort="mgsR, S928, rsbRD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2260698..2260703 /Source="Nicolas_upshift_promotors" /id="U1923" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1002 /SigmaFactorBS="ttcatttaaaccatttacagaacttttttcGGATTAtttttt aaaaaacatTCATACAATAGAAAACACAatcaaagggacaaattccatttgtatatta a" /GFF_Attribute="listShort" /listLong="yqgY, S929, yqgW, S930" /label="promotor_-35" promotor_-10 2260719..2260737 /Source="Nicolas_upshift_promotors" /id="U1923" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1002 /SigmaFactorBS="ttcatttaaaccatttacagaacttttttcGGATTAtttttt aaaaaacatTCATACAATAGAAAACACAatcaaagggacaaattccatttgtatatta a" /GFF_Attribute="listShort" /listLong="yqgY, S929, yqgW, S930" /label="promotor_-10" upshifts 2260728 /Source="Nicolas_upshifts" /id="U1923" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1002 /SigmaFactorBS="ttcatttaaaccatttacagaacttttttcGGATTAtttttt aaaaaacatTCATACAATAGAAAACACAatcaaagggacaaattccatttgtatatta a" /GFF_Attribute="listShort" /listLong="yqgY, S929, yqgW, S930" /label="upshifts" promotor_-35 2260778..2260785 /Source="Nicolas_upshift_promotors" /id="U1924" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=513 /SigmaFactorBS="caaagggacaaattccatttgtatattaataatgaaaaTGTT TACAtttctaggtgtgatcTATTATAATAACAGTCAGAGggactctcgggaggggata a" /listShort="yqgY, S929" /listLong="yqgW, S930" /label="promotor_-35" upshifts 2260800 /Source="Nicolas_upshifts" /id="U1924" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=513 /SigmaFactorBS="caaagggacaaattccatttgtatattaataatgaaaaTGTT TACAtttctaggtgtgatcTATTATAATAACAGTCAGAGggactctcgggaggggata a" /listShort="yqgY, S929" /listLong="yqgW, S930" /label="upshifts" promotor_-10 2260801..2260820 /Source="Nicolas_upshift_promotors" /id="U1924" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=513 /SigmaFactorBS="caaagggacaaattccatttgtatattaataatgaaaaTGTT TACAtttctaggtgtgatcTATTATAATAACAGTCAGAGggactctcgggaggggata a" /listShort="yqgY, S929" /listLong="yqgW, S930" /label="promotor_-10" CDS 2260843..2261088 /gene="yqgY" /locus_tag="BSU_24780" /old_locus_tag="BSU24780" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390358.1" /db_xref="EnsemblGenomes-Gn:BSU24780" /db_xref="EnsemblGenomes-Tr:CAB14409" /db_xref="GOA:P54502" /db_xref="InterPro:IPR020254" /db_xref="SubtiList:BG11692" /db_xref="UniProtKB/Swiss-Prot:P54502" /translation="MNRMFRVLGFWTGIFAVMFYLGDMKDASLLFFGQTILFVFLSYL NLTERMYIYIFGAYLTIFFAGFTYYSIFIMVPGGGGH*" /label="yqgY CDS" gene 2260843..2261088 /gene="yqgY" /locus_tag="BSU_24780" /old_locus_tag="BSU24780" /label="yqgY gene" downshifts 2260985 /Source="Nicolas_upshifts" /id="D1285" /incds=1 /nref=1 /ntot=86 /MaxReadThrough="6.68961" /MaxDrop="2.1025" /score="22.3415753" /energy="-13.7" /TU="U1924" /idTUdmin="U1923" /TUdmin=176 /isTUend="FALSE" /label="downshifts" downshifts 2261074 /Source="Nicolas_upshifts" /id="D1286" /incds=0 /nref=98 /ntot=234 /MaxReadThrough="4.03872" /MaxDrop="5.76938" /score="22.3415753" /energy="-13.7" /TU="U1924" /idTUdmin="U1923" /TUdmin=265 /isTUend="FALSE" /label="downshifts" S_feature 2261119..2261874 /Source="Nicolas_S_feature" /locus_tag="new_2564914_2565669" /HighExp="M9-stat, T0.30H, T1.30H, LoTm, T1.0H, B60, T2.0H, S5, S4, T2.30H" /AntisenseName="yqgX" /AntisenseCor="-0.68109878166952498" /AntisenseRegPval="-37.299999999999997" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigEF" /TUlongPSig=1 /label="S929" CDS complement(2261128..2261763) /gene="yqgX" /locus_tag="BSU_24790" /old_locus_tag="BSU24790" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20669241, 22333191; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-binding hydrolase" /protein_id="NP_390359.1" /db_xref="EnsemblGenomes-Gn:BSU24790" /db_xref="EnsemblGenomes-Tr:CAB14410" /db_xref="GOA:P54501" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG11691" /db_xref="UniProtKB/Swiss-Prot:P54501" /translation="MKWRRMPVGPIQANAYFLISDDQCLIFDPGGEGHKINQYIKEKG LTPLAILLTHAHFDHIGALDEVREKWDIPVYLHQNEKNWLADASLNGSGMLRGIEVTA KPADHLIEGDGELNIGPFHLETLFTPGHSPGSVSYYVKDADLVISGDVLFQGGIGRTD LIGGNQETLLTSIHEKLLTLPEHTLVLSGHGPETDVLTEQDQNPFLNGFSL*" /label="yqgX CDS" gene complement(2261128..2261763) /gene="yqgX" /locus_tag="BSU_24790" /old_locus_tag="BSU24790" /label="yqgX gene" downshifts complement(2261153) /Source="Nicolas_upshifts" /id="D1287" /incds=0 /nref=154 /ntot=239 /MaxReadThrough="1.42757" /MaxDrop="5.15622" /score="-8.36666809" /energy="-13.7" /TU="NA" /idTUdmin="U1925" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2261785..2261804) /Source="Nicolas_upshift_promotors" /id="U1925" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=2361 /SigmaFactorBS="ttttttataggtttgtcgatagcgttttcattgcgatTGTTT GAAtcttttttcaaaaACCCTCATAATAAGAGCATAaaaaagaaagaggtgataatag t" /listShort="yqgX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2261802) /Source="Nicolas_upshifts" /id="U1925" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=2361 /SigmaFactorBS="ttttttataggtttgtcgatagcgttttcattgcgatTGTTT GAAtcttttttcaaaaACCCTCATAATAAGAGCATAaaaaagaaagaggtgataatag t" /listShort="yqgX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2261818..2261825) /Source="Nicolas_upshift_promotors" /id="U1925" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=2361 /SigmaFactorBS="ttttttataggtttgtcgatagcgttttcattgcgatTGTTT GAAtcttttttcaaaaACCCTCATAATAAGAGCATAaaaaagaaagaggtgataatag t" /listShort="yqgX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2261842..2261849 /Source="Nicolas_upshift_promotors" /id="U1926" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=514 /SigmaFactorBS="gattcaaacaatcgcaatgaaaacgcTATCGACAaacctata aaaaacAGGTAGAATAAAACTGGAAAgaattgcaggtttttcaatgtaaagggggctg t" /listShort="yqgW, S930" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2261864..2261883 /Source="Nicolas_upshift_promotors" /id="U1926" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=514 /SigmaFactorBS="gattcaaacaatcgcaatgaaaacgcTATCGACAaacctata aaaaacAGGTAGAATAAAACTGGAAAgaattgcaggtttttcaatgtaaagggggctg t" /listShort="yqgW, S930" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2261876 /Source="Nicolas_upshifts" /id="U1926" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=514 /SigmaFactorBS="gattcaaacaatcgcaatgaaaacgcTATCGACAaacctata aaaaacAGGTAGAATAAAACTGGAAAgaattgcaggtttttcaatgtaaagggggctg t" /listShort="yqgW, S930" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2261896) /Source="Nicolas_upshifts" /id="U1927" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.996003996003996" /psig=0 /xcortree=709 /SigmaFactorBS="aaagagcgacaaggccgaaaatcacgacaagtAACATaacac agCCCCCTTTACATTGAaaaacctgcaattctttccagttttattctacctgtttttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2261898..2261912) /Source="Nicolas_upshift_promotors" /id="U1927" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.996003996003996" /psig=0 /xcortree=709 /SigmaFactorBS="aaagagcgacaaggccgaaaatcacgacaagtAACATaacac agCCCCCTTTACATTGAaaaacctgcaattctttccagttttattctacctgtttttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2261920..2261924) /Source="Nicolas_upshift_promotors" /id="U1927" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.996003996003996" /psig=0 /xcortree=709 /SigmaFactorBS="aaagagcgacaaggccgaaaatcacgacaagtAACATaacac agCCCCCTTTACATTGAaaaacctgcaattctttccagttttattctacctgtttttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2261920..2262093 /gene="yqgW" /locus_tag="BSU_24800" /old_locus_tag="BSU24800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390360.1" /db_xref="EnsemblGenomes-Gn:BSU24800" /db_xref="EnsemblGenomes-Tr:CAB14411" /db_xref="GOA:P54500" /db_xref="InterPro:IPR024490" /db_xref="SubtiList:BG11690" /db_xref="UniProtKB/Swiss-Prot:P54500" /translation="MLLVVIFGLVALFALWGVLRSVRNKNILGFLLAGATLFVFGWFT VMTVINSGYPTAH*" /label="yqgW CDS" gene 2261920..2262093 /gene="yqgW" /locus_tag="BSU_24800" /old_locus_tag="BSU24800" /label="yqgW gene" downshifts 2262081 /Source="Nicolas_upshifts" /id="D1288" /incds=0 /nref=255 /ntot=278 /MaxReadThrough="3.92092" /MaxDrop="7.18555" /score="14.1643615" /energy="-12.4" /TU="U1926" /idTUdmin="U1924" /TUdmin=217 /isTUend="FALSE" /label="downshifts" CDS complement(2262125..2262439) /gene="yqgV" /locus_tag="BSU_24810" /old_locus_tag="BSU24810" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390361.2" /db_xref="EnsemblGenomes-Gn:BSU24810" /db_xref="EnsemblGenomes-Tr:CAB14412" /db_xref="GOA:P54499" /db_xref="InterPro:IPR002767" /db_xref="InterPro:IPR029756" /db_xref="SubtiList:BG11689" /db_xref="UniProtKB/Swiss-Prot:P54499" /translation="MAIADVTIIPIGTETPSVSAYVADVQKILEGYQAEGKIKYQLTP MNTLIEGELSDLFAVIQAIHEAPFQKGLHRVATNIRIDDRRDKKTTLESKIESVNKHL QP*" /label="yqgV CDS" gene complement(2262125..2262439) /gene="yqgV" /locus_tag="BSU_24810" /old_locus_tag="BSU24810" /label="yqgV gene" S_feature 2262126..2263193 /Source="Nicolas_S_feature" /locus_tag="new_2565921_2566988" /HighExp="LoTm, M9-stat, C30, Cold, S8, S7, B60, Lbstat, G135, C90" /AntisenseName="yqgV" /AntisenseCor="-0.23995763414552801" /AntisenseRegPval="-4.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigEF" /TUlongPSig="1, 1" /label="S930" downshifts complement(2262139) /Source="Nicolas_upshifts" /id="D1289" /incds=0 /nref=247 /ntot=265 /MaxReadThrough="2.24429" /MaxDrop="6.85096" /score="0.185625845" /energy="-12.4" /TU="NA" /idTUdmin="U1928" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2262442..2263503) /gene="yqgU" /locus_tag="BSU_24820" /old_locus_tag="BSU24820" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_390362.2" /db_xref="EnsemblGenomes-Gn:BSU24820" /db_xref="EnsemblGenomes-Tr:CAB14413" /db_xref="GOA:P54498" /db_xref="SubtiList:BG11688" /db_xref="UniProtKB/Swiss-Prot:P54498" /translation="MLMRSVCFILLAVLLFSLSACEPSHQQQKQASAAKDEKKDIIPL SAEKADGAEGWLNNSTILYTASNPTKTELFAYRIFTGKAKKLYQTDGQIVDVQINARE QMILLQITHSQKTAVVLLNAEGETLYEKDYETYELEAAWNQYDPYQMMVTEFNENWDF HTYQVNAKKDESFLSPVQVPFIHWTSKNTFDYVKEGRDDKTGPLYTFDTASKTEQKLE DNVLFFDSFHQMSFTVKSASGGKGTYQFKTPQSTSPVTAKWPLQAKYTSLAPMEYDYD EAGGLFYTFKQSGDAYKLAAINVASGETKDLVSLREMEPIQISPNGKYALYGFHFEQI ILLKSHETKQLIIDQKEME*" /label="yqgU CDS" gene complement(2262442..2263503) /gene="yqgU" /locus_tag="BSU_24820" /old_locus_tag="BSU24820" /label="yqgU gene" CDS complement(2263565..2264695) /gene="yqgT" /locus_tag="BSU_24830" /old_locus_tag="BSU24830" /function="16.13: Shape" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12765833, 24163346; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative d,l-endopeptidase" /protein_id="NP_390363.1" /db_xref="EnsemblGenomes-Gn:BSU24830" /db_xref="EnsemblGenomes-Tr:CAB14414" /db_xref="GOA:P54497" /db_xref="InterPro:IPR000834" /db_xref="InterPro:IPR034274" /db_xref="SubtiList:BG11687" /db_xref="UniProtKB/Swiss-Prot:P54497" /translation="MMAFITVKPEIKNNLANVAKELKIDEELLKSANRSAQKHQLYCP GYVIEEHSGKELQTIQDIKRFLQPRQLKLSDSWIEQEKIYDDSAVEKEIKKIIDVFPF VSCREIGRSVLGRPIWELKAGGEHAVKKVHMNASFHANEWITTSVLLKWFKEYCMSLC CNSPFFGFSPIKLFNSTSLSLVPLVNPDGVDLVLNGSEVMGARRDELERLNEHRPNFN EWKANINGVDLNKQFPSLWEIEKYRKPTAPSYRDFPGISPLTEPESIAMYRLITENPP DRLLALHTQGEEIYWGYKGLEPEESAAVIKEFEELSGNIYKGVRDIDSYAGFRDWFIH HYFKEGYTVELGKGQNPLPFQQFSHIYNATSGILWRALFFHE*" /label="yqgT CDS" gene complement(2263565..2264695) /gene="yqgT" /locus_tag="BSU_24830" /old_locus_tag="BSU24830" /label="yqgT gene" promotor_-10 complement(2264703..2264721) /Source="Nicolas_upshift_promotors" /id="U1928" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.927072927072927" /psig="0.927072927072927" /xcortree=1180 /SigmaFactorBS="cttgatcaggcatcataatcacaatgtctcccgcatcgaagt gagcgggaggcTTTCTTtttttaaatacgctgTCATATAGTAACAAAAAAGggggatg a" /listShort="yqgT, yqgU, yqgV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2264735) /Source="Nicolas_upshifts" /id="U1928" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.927072927072927" /psig="0.927072927072927" /xcortree=1180 /SigmaFactorBS="cttgatcaggcatcataatcacaatgtctcccgcatcgaagt gagcgggaggcTTTCTTtttttaaatacgctgTCATATAGTAACAAAAAAGggggatg a" /listShort="yqgT, yqgU, yqgV" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2264737..2264742) /Source="Nicolas_upshift_promotors" /id="U1928" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.927072927072927" /psig="0.927072927072927" /xcortree=1180 /SigmaFactorBS="cttgatcaggcatcataatcacaatgtctcccgcatcgaagt gagcgggaggcTTTCTTtttttaaatacgctgTCATATAGTAACAAAAAAGggggatg a" /listShort="yqgT, yqgU, yqgV" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2264778..2266694) /gene="ltaSC" /locus_tag="BSU_24840" /old_locus_tag="BSU24840" /function="16.13: Shape" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15187182, 21255105, 23103977, 25288647, 25666134" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15187182, 21255105, 23103977, 25288647, 25666134; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enzyme responsible for polyglycerolphosphate LTAsynthesis" /protein_id="NP_390364.2" /db_xref="EnsemblGenomes-Gn:BSU24840" /db_xref="EnsemblGenomes-Tr:CAB14415" /db_xref="GOA:P54496" /db_xref="InterPro:IPR000917" /db_xref="InterPro:IPR012160" /db_xref="InterPro:IPR017849" /db_xref="InterPro:IPR017850" /db_xref="SubtiList:BG11686" /db_xref="UniProtKB/Swiss-Prot:P54496" /translation="MRKTFFSKISFMLIAILLMWLKTYAVYKTSFHIKIDNLTQEFIL FINPLSFLLLIFGLSLFLKGKNRNRYIIAMSCLVTFVLLANMVFYRFYNDFLTIPVLF QTSNMGDLGSSIGTLLEPTDLLLAVDIAVLIWLHIRQKAFQSDIPSTKNERAAYFLFV ASVYFFNLGLSEAERPQLLTRSFDREMLVKNISLFNFHIYDGVLQSKQSAQRALADSN SLTEIENYVTANAKDANKRLFGAAKGRNVILVSLESTQSFVINEKLNGEEITPFLNDF IKQSYNFNNVYHQTGQGKTSDSEFIVDNSLYPLGRGAVFFTNAGNQYMAAPEILKNSG YYSAVLHANNKSFWNRDLMYDSFGYDSFFDINSYDVTDENSVGWGLKDKEFFEQSSEL MKNLPQPFYSRLITLTNHFPFDLDEEDQLIDEYDSNSQTLNKYFPTVRYQDEALKRFI EKLKEDGLYDNSVIVLYGDHYGISENHNEAMGQFLGKEITPFEEVQLQKVPLVIHIPG ITDKKPQTIETVGGQIDIRPTLMNLLGIDTKDQIQFGNDLLSDEKLDFTVLRDGSFIT DQVVYTDGACYDKETGKPLEETKQCEAFADKAKQELSLSDEIIYGDLLRFYDQKRLDN SSKRKEKQMLDQAS*" /label="ltaSC CDS" gene complement(2264778..2266694) /gene="ltaSC" /locus_tag="BSU_24840" /old_locus_tag="BSU24840" /label="ltaSC gene" downshifts complement(2264805) /Source="Nicolas_upshifts" /id="D1290" /incds=0 /nref=5 /ntot=142 /MaxReadThrough="4.5611" /MaxDrop="3.8416" /score="15.4764643" /energy="-14.5" /TU="U1930,U1931" /idTUdmin="U1928" /TUdmin="-2667" /isTUend="FALSE" /label="downshifts" promotor_-35 2265810..2265816 /Source="Nicolas_upshift_promotors" /id="U1929" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=213 /SigmaFactorBS="agcggatacagtgaattgtccacgataaattcagaatccgaG GTTTTCccctggcctgtttggTGGTAAACATTATTAAAGTtgtagctctgttttataa a" /listShort="S931" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2265829..2266858 /Source="Nicolas_S_feature" /locus_tag="new_2569624_2570653" /HighExp="Etha, Gly, M9-stat, Salt, S8, LPhT, S7, Sw, HiTm, B60" /AntisenseName="yqgS" /AntisenseCor="-0.36996929809172002" /AntisenseRegPval="-9.4" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S931" upshifts 2265829 /Source="Nicolas_upshifts" /id="U1929" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=213 /SigmaFactorBS="agcggatacagtgaattgtccacgataaattcagaatccgaG GTTTTCccctggcctgtttggTGGTAAACATTATTAAAGTtgtagctctgttttataa a" /listShort="S931" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2265832..2265850 /Source="Nicolas_upshift_promotors" /id="U1929" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=213 /SigmaFactorBS="agcggatacagtgaattgtccacgataaattcagaatccgaG GTTTTCccctggcctgtttggTGGTAAACATTATTAAAGTtgtagctctgttttataa a" /listShort="S931" /GFF_Attribute="listLong" /label="promotor_-10" S_feature complement(2266695..2266761) /Source="Nicolas_S_feature" /locus_tag="new_2570490_2570556_c" /HighExp="T-3.40H, BC, Sw, S5, Lbstat, T-5.40H, S4, ferm, C30, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S932" promotor_-10 complement(2266755..2266774) /Source="Nicolas_upshift_promotors" /id="U1930" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.483516483516484" /psig=1 /xcortree=3130 /SigmaFactorBS="aaaattgttaaaattgtgtaaatgaAATTGATTttttgttgt gctcaGGTTAAGATTTAATTTGATGtgttaatgagaatgttgggaatagactgatttt t" /listShort="S932, yqgS, yqgT, yqgU, yqgV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2266761) /Source="Nicolas_upshifts" /id="U1930" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.483516483516484" /psig=1 /xcortree=3130 /SigmaFactorBS="aaaattgttaaaattgtgtaaatgaAATTGATTttttgttgt gctcaGGTTAAGATTTAATTTGATGtgttaatgagaatgttgggaatagactgatttt t" /listShort="S932, yqgS, yqgT, yqgU, yqgV" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2266789..2266796) /Source="Nicolas_upshift_promotors" /id="U1930" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.483516483516484" /psig=1 /xcortree=3130 /SigmaFactorBS="aaaattgttaaaattgtgtaaatgaAATTGATTttttgttgt gctcaGGTTAAGATTTAATTTGATGtgttaatgagaatgttgggaatagactgatttt t" /listShort="S932, yqgS, yqgT, yqgU, yqgV" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2266811..2267776) /gene="glcK" /locus_tag="BSU_24850" /old_locus_tag="BSU24850" /EC_number="2.7.1.59" /EC_number="2.7.1.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9620975, 10737197, 15018644, 15050034, 20495944, 21108133, 27324299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9620975, 10737197, 15018644, 15050034, 20495944, 21108133, 27324299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucose kinase" /protein_id="NP_390365.2" /db_xref="EnsemblGenomes-Gn:BSU24850" /db_xref="EnsemblGenomes-Tr:CAB14416" /db_xref="GOA:P54495" /db_xref="InterPro:IPR000600" /db_xref="InterPro:IPR004654" /db_xref="SubtiList:BG11685" /db_xref="UniProtKB/Swiss-Prot:P54495" /translation="MDEIWFAGIDLGGTTIKLAFINQYGEIQHKWEVPTDKTGDTITV TIAKTIDSKLDELQKPKHIIKYIGMGAPGPVDMAAGVVYETVNLGWKNYALKNHLETE TGIPAVIENDANIAALGEMWKGAGDGAKDVILVTLGTGVGGGIIANGEIVHGINGAGG EIGHICSIPEGGAPCNCGKTGCIETIASATGIVRIAKEKIANAKKTTRLKATEQLSAR DVFEAAGENDEIALEVVDYVAKHLGLVLGNLASSLNPSKIVLGGGVSRAGELLRSKVE KTFRKCAFPRAAQAADISIAALGNDAGVIGGAWIAKNEWLKHQNC*" /label="glcK CDS" gene complement(2266811..2267776) /gene="glcK" /locus_tag="BSU_24850" /old_locus_tag="BSU24850" /label="glcK gene" CDS complement(2267787..2268002) /gene="yqgQ" /locus_tag="BSU_24860" /old_locus_tag="BSU24860" /function="9.3: Transcription factors" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15050034, 20057058; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative single strand nucleic acid binding transcription factor" /protein_id="NP_390366.1" /db_xref="EnsemblGenomes-Gn:BSU24860" /db_xref="EnsemblGenomes-Tr:CAB14417" /db_xref="InterPro:IPR009256" /db_xref="InterPro:IPR023164" /db_xref="PDB:2NN4" /db_xref="SubtiList:BG11684" /db_xref="UniProtKB/Swiss-Prot:P54494" /translation="MNTFYDVQQLLKTFGHIVYFGDRELEIEFMLDELKELYMNHMIE KEQWARAAAVLRKELEQTKNGRDFYKG*" /label="yqgQ CDS" gene complement(2267787..2268002) /gene="yqgQ" /locus_tag="BSU_24860" /old_locus_tag="BSU24860" /label="yqgQ gene" S_feature complement(2268003..2268111) /Source="Nicolas_S_feature" /locus_tag="new_2571798_2571906_c" /HighExp="M0t90, Lbstat, M40t90, M40t45, Lbtran, Mt0, dia5, Diami, M0t45, BI" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S933" CDS complement(2268112..2269635) /gene="glpG" /locus_tag="BSU_24870" /old_locus_tag="BSU24870" /EC_number="3.4.21.105" /function="16.1: Circulate" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15050034, 16355228, 23518036, 26858402; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="membrane endopeptidase" /protein_id="NP_390367.2" /db_xref="EnsemblGenomes-Gn:BSU24870" /db_xref="EnsemblGenomes-Tr:CAB14418" /db_xref="GOA:P54493" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="InterPro:IPR022764" /db_xref="InterPro:IPR035952" /db_xref="SubtiList:BG11683" /db_xref="UniProtKB/Swiss-Prot:P54493" /translation="MFLLEYTYWKIAAHLVNSGYGVIQAGESDEIWLEAPDKSSHDLV RLYKHDLDFRQEMVRDIEEQAERVERVRHQLGRRRMKLLNVFFSTEAPVDDWEEIAKK TFEKGTVSVEPAIVRGTMLRDDLQAVFPSFRTEDCSEEHASFENAQMARERFLSLVLK QEEQRKTEAAVFQNGKPTFTYLFIALQILMFFLLEINGGSTNTETLVAFGAKENSLIA QGEWWRLLTPIVLHIGIAHLAFNTLALWSVGTAVERMYGSGRFLLIYLAAGITGSIAS FVFSPYPSAGASGAIFGCLGALLYVALSNRKMFLRTIGTNIIVIIIINLGFGFAVSNI DNSGHIGGLIGGFFAAAALGLPKAGAFGKRLLSAVLLIALAVGFLYYGLHSPSHQESA LIQQASELYQEGKYEEVTELLNGEAAQKDASADLLKILAVSDIQIGEYDQAVSLLERA VKKEPKDHASYYNLALLYAEKNELAQAEKAIQTAVKLKPKEQRYKELQRQIENNKES* " /label="glpG CDS" gene complement(2268112..2269635) /gene="glpG" /locus_tag="BSU_24870" /old_locus_tag="BSU24870" /label="glpG gene" promotor_-10 complement(2269653..2269672) /Source="Nicolas_upshift_promotors" /id="U1931" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.602397602397602" /psig=1 /xcortree=2337 /SigmaFactorBS="aaaatcccgtgaaaaacgggattttttgctttCAGTAGGCgt ttcggagcgccaGCTGTTATAATGAAAAAAAActattggagcggtaaacatgtttttg c" /listShort="glpG, S933, yqgQ, glcK, S932, yqgS, yqgT, yqgU, yqgV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2269666) /Source="Nicolas_upshifts" /id="U1931" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.602397602397602" /psig=1 /xcortree=2337 /SigmaFactorBS="aaaatcccgtgaaaaacgggattttttgctttCAGTAGGCgt ttcggagcgccaGCTGTTATAATGAAAAAAAActattggagcggtaaacatgtttttg c" /listShort="glpG, S933, yqgQ, glcK, S932, yqgS, yqgT, yqgU, yqgV" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2269687..2269694) /Source="Nicolas_upshift_promotors" /id="U1931" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.602397602397602" /psig=1 /xcortree=2337 /SigmaFactorBS="aaaatcccgtgaaaaacgggattttttgctttCAGTAGGCgt ttcggagcgccaGCTGTTATAATGAAAAAAAActattggagcggtaaacatgtttttg c" /listShort="glpG, S933, yqgQ, glcK, S932, yqgS, yqgT, yqgU, yqgV" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2269725..2269898) /gene="yqgO" /locus_tag="BSU_24880" /old_locus_tag="BSU24880" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390368.1" /db_xref="EnsemblGenomes-Gn:BSU24880" /db_xref="EnsemblGenomes-Tr:CAB14419" /db_xref="SubtiList:BG11682" /db_xref="UniProtKB/Swiss-Prot:P54492" /translation="MKKLLIYAIFAVSAVMFYQNRYRLMNTVLSQPGIRRSFIHLFLR IPFIRNKFIQQAF*" /label="yqgO CDS" gene complement(2269725..2269898) /gene="yqgO" /locus_tag="BSU_24880" /old_locus_tag="BSU24880" /label="yqgO gene" downshifts complement(2269752) /Source="Nicolas_upshifts" /id="D1291" /incds=0 /nref=121 /ntot=211 /MaxReadThrough="2.93694" /MaxDrop="5.6047" /score="19.2452946" /energy="-8.9" /TU="NA" /idTUdmin="U1932" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2269914..2269925) /Source="Nicolas_upshift_promotors" /id="U1932" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=909 /SigmaFactorBS="gattatttcttgtttttcataactttcctgtcccttattcgA GAATAAataaggtagaataACAAACCCTATTggcaggagggatatcatgaaaaaactt t" /listShort="yqgO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2269926) /Source="Nicolas_upshifts" /id="U1932" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=909 /SigmaFactorBS="gattatttcttgtttttcataactttcctgtcccttattcgA GAATAAataaggtagaataACAAACCCTATTggcaggagggatatcatgaaaaaactt t" /listShort="yqgO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2269939..2269945) /Source="Nicolas_upshift_promotors" /id="U1932" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=909 /SigmaFactorBS="gattatttcttgtttttcataactttcctgtcccttattcgA GAATAAataaggtagaataACAAACCCTATTggcaggagggatatcatgaaaaaactt t" /listShort="yqgO" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2269965..2270528) /gene="folN" /locus_tag="BSU_24890" /old_locus_tag="BSU24890" /EC_number="6.3.3.2" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17329806, 20952389, 22773193; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5-formyltetrahydrofolate cyclo-ligase" /protein_id="NP_390369.1" /db_xref="EnsemblGenomes-Gn:BSU24890" /db_xref="EnsemblGenomes-Tr:CAB14420" /db_xref="GOA:P54491" /db_xref="InterPro:IPR002698" /db_xref="PDB:1YDM" /db_xref="SubtiList:BG11681" /db_xref="UniProtKB/Swiss-Prot:P54491" /translation="MKSQLRKKTLEALSALSNEDILQKTERMYKYLFSLPEWQNAGTI AVTISRGLEIPTRPVIEQAWEEGKQVCIPKCHPDTKKMQFRTYQTDDQLETVYAGLLE PVIEKTKEVNPSQIDLMIVPGVCFDVNGFRVGFGGGYYDRYLSEYEGKTVSLLLECQL FAHVPRLPHDIPVHKLITEDRIISCFS*" /label="folN CDS" gene complement(2269965..2270528) /gene="folN" /locus_tag="BSU_24890" /old_locus_tag="BSU24890" /label="folN gene" S_feature complement(2270529..2270612) /Source="Nicolas_S_feature" /locus_tag="new_2574324_2574407_c" /HighExp="Cold, G180, LBGexp, LBGtran, G135, HPh, LPh, dia0, Oxctl, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S934" CDS complement(2270613..2270762) /gene="rpmGA" /locus_tag="BSU_24900" /old_locus_tag="BSU24900" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 12904577, 19648245, 22720735, 23002217, 27561249; Product type s : structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L33" /protein_id="NP_570908.2" /db_xref="EnsemblGenomes-Gn:BSU24900" /db_xref="EnsemblGenomes-Tr:CAE01461" /db_xref="GOA:P56849" /db_xref="InterPro:IPR001705" /db_xref="InterPro:IPR011332" /db_xref="InterPro:IPR018264" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG14180" /db_xref="UniProtKB/Swiss-Prot:P56849" /translation="MRVNITLACTECGERNYISKKNKRNNPDRVEFKKYCPRDKKSTL HRETK*" /label="rpmGA CDS" gene complement(2270613..2270762) /gene="rpmGA" /locus_tag="BSU_24900" /old_locus_tag="BSU24900" /label="rpmGA gene" downshifts complement(2270659) /Source="Nicolas_upshifts" /id="D1292" /incds=0 /nref=154 /ntot=253 /MaxReadThrough="5.3064" /MaxDrop="4.5881" /score="34.7393253" /energy="-15.3" /TU="U1933" /idTUdmin="U1932" /TUdmin="-907" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2270799..2270818) /Source="Nicolas_upshift_promotors" /id="U1933" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=2638 /SigmaFactorBS="ttcaataattcagcaattcattgaaaaacagcCTAGcattcc gtccattatAGTGGTATTATATATAAGTCtgaataagtaaatgattttagtttggagg g" /listShort="rpmGA, S934, yqgN, yqgO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2270809) /Source="Nicolas_upshifts" /id="U1933" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=2638 /SigmaFactorBS="ttcaataattcagcaattcattgaaaaacagcCTAGcattcc gtccattatAGTGGTATTATATATAAGTCtgaataagtaaatgattttagtttggagg g" /listShort="rpmGA, S934, yqgN, yqgO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2270834..2270837) /Source="Nicolas_upshift_promotors" /id="U1933" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=2638 /SigmaFactorBS="ttcaataattcagcaattcattgaaaaacagcCTAGcattcc gtccattatAGTGGTATTATATATAAGTCtgaataagtaaatgattttagtttggagg g" /listShort="rpmGA, S934, yqgN, yqgO" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2270846..2271925) /gene="yqgM" /locus_tag="BSU_24910" /old_locus_tag="BSU24910" /EC_number="2.4.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_390370.2" /db_xref="EnsemblGenomes-Gn:BSU24910" /db_xref="EnsemblGenomes-Tr:CAB14421" /db_xref="GOA:P54490" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR028098" /db_xref="SubtiList:BG11680" /db_xref="UniProtKB/Swiss-Prot:P54490" /translation="MNILMLSPEHPDEPKSGLGVHLNRLISYLNPHINITVFTPSGQL FSYAKFEDYIADANFTMVRHVLSHNKRFDLIHAHDDTTAPAAQYLKQRLGLPLAATIH GLESERKKVCREAPHPYRLMTERLLIESADALIVLSTFMKRSLDKAAHKKITVIPSPA SMEEEKGKIPRSMNRRFLFSYGRFVPEKGLSQLLKVFAILKQRQPDLYLVLAGEGPSL SCYEKLAAAYNLKDRVMFLPFLNRKDIRTLLSHCEMAVFPSSYEPFGLAAQESMEQGV LTVVSQSGGFCDYAVHDKTAIIADFTLVQEAADLLDSFLKDREKARRIKEAGRQQVFK LHHPRLIMSSYLQLYERIFNNSAIH*" /label="yqgM CDS" gene complement(2270846..2271925) /gene="yqgM" /locus_tag="BSU_24910" /old_locus_tag="BSU24910" /label="yqgM gene" CDS complement(2271922..2272392) /gene="yqgL" /locus_tag="BSU_24920" /old_locus_tag="BSU24920" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390371.1" /db_xref="EnsemblGenomes-Gn:BSU24920" /db_xref="EnsemblGenomes-Tr:CAB14422" /db_xref="SubtiList:BG11679" /db_xref="UniProtKB/Swiss-Prot:P54489" /translation="MDKHPFPYNIRHKLSFFRDTFDIIIQNAHTLTVSWEISEETMRL AEAVLFEKTQDMIKELRIVIKRKDIEAVRTKRTTYDKGEWTIRQAAGDAVYRAEYRIV NSMNVSLKLAGTDDIYLDENGIRHINSFQIEEAHTRWEAQFSAYTCYGRGEKER*" /label="yqgL CDS" gene complement(2271922..2272392) /gene="yqgL" /locus_tag="BSU_24920" /old_locus_tag="BSU24920" /label="yqgL gene" promotor_-35 2272337..2272345 /Source="Nicolas_upshift_promotors" /id="U1934" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=1724 /SigmaFactorBS="aaggtgtgagcgttttgaatgattatgtcgaatgtgTCCCTA AAAaaggaaagcttatGTCGTATATtatagggaaatgggtgtttatccatggactcct a" /listShort="S935, yqzD, yqzC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2272359..2272367 /Source="Nicolas_upshift_promotors" /id="U1934" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=1724 /SigmaFactorBS="aaggtgtgagcgttttgaatgattatgtcgaatgtgTCCCTA AAAaaggaaagcttatGTCGTATATtatagggaaatgggtgtttatccatggactcct a" /listShort="S935, yqzD, yqzC" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2272360..2272533 /Source="Nicolas_S_feature" /locus_tag="new_2576155_2576328" /HighExp="M9-stat, T1.0H, T1.30H, T0.30H, T2.0H, T2.30H, T3.0H, Lbstat, T3.30H, B60" /AntisenseName="yqgL" /AntisenseCor="0.210779859401483" /AntisenseRegPval="-3.3" /CDS_PredictionProba="NA" /TUshortSig="SigI" /TUshortPSig="0.982" /TUlongSig="NA" /TUlongPSig="NA" /label="S935" upshifts 2272361 /Source="Nicolas_upshifts" /id="U1934" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.982017982017982" /psig="0.982017982017982" /xcortree=1724 /SigmaFactorBS="aaggtgtgagcgttttgaatgattatgtcgaatgtgTCCCTA AAAaaggaaagcttatGTCGTATATtatagggaaatgggtgtttatccatggactcct a" /listShort="S935, yqzD, yqzC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2272428..2272447) /Source="Nicolas_upshift_promotors" /id="U1935" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.768231768231768" /psig="0.999000999001" /xcortree=2933 /SigmaFactorBS="cgcgaaaaaaacgagattttgtcgagaaatctttCTTCGCTT cttcttcatgtAATGGTTTAATAGGAACACGaagtgaacgattggaaaggagaatgtt a" /listShort="yqgL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2272440) /Source="Nicolas_upshifts" /id="U1935" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.768231768231768" /psig="0.999000999001" /xcortree=2933 /SigmaFactorBS="cgcgaaaaaaacgagattttgtcgagaaatctttCTTCGCTT cttcttcatgtAATGGTTTAATAGGAACACGaagtgaacgattggaaaggagaatgtt a" /listShort="yqgL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2272459..2272466) /Source="Nicolas_upshift_promotors" /id="U1935" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.768231768231768" /psig="0.999000999001" /xcortree=2933 /SigmaFactorBS="cgcgaaaaaaacgagattttgtcgagaaatctttCTTCGCTT cttcttcatgtAATGGTTTAATAGGAACACGaagtgaacgattggaaaggagaatgtt a" /listShort="yqgL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2272505..2272509 /Source="Nicolas_upshift_promotors" /id="U1936" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.806193806193806" /psig="0.995004995004995" /xcortree=2671 /SigmaFactorBS="ctcgacaaaatctcgtttttttcgcgaattCCTTTagaaact attggtttTATGGTATAAAAAAGAAGGAtaaaaaaagaatagaaggtgatgaaacgtg g" /listShort="yqzD, yqzC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2272525..2272544 /Source="Nicolas_upshift_promotors" /id="U1936" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.806193806193806" /psig="0.995004995004995" /xcortree=2671 /SigmaFactorBS="ctcgacaaaatctcgtttttttcgcgaattCCTTTagaaact attggtttTATGGTATAAAAAAGAAGGAtaaaaaaagaatagaaggtgatgaaacgtg g" /listShort="yqzD, yqzC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2272535 /Source="Nicolas_upshifts" /id="U1936" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.806193806193806" /psig="0.995004995004995" /xcortree=2671 /SigmaFactorBS="ctcgacaaaatctcgtttttttcgcgaattCCTTTagaaact attggtttTATGGTATAAAAAAGAAGGAtaaaaaaagaatagaaggtgatgaaacgtg g" /listShort="yqzD, yqzC" /GFF_Attribute="listLong" /label="upshifts" CDS 2272572..2272925 /gene="yqzD" /locus_tag="BSU_24930" /old_locus_tag="BSU24930" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390372.1" /db_xref="EnsemblGenomes-Gn:BSU24930" /db_xref="EnsemblGenomes-Tr:CAB14423" /db_xref="GOA:O32022" /db_xref="SubtiList:BG13770" /db_xref="UniProtKB/Swiss-Prot:O32022" /translation="MEIAIIALFIVSIALIAFSYSQRDPMKDVEQELETLQLSAMQEI YKLKKKMTVLEEELLETNLVIRKSKQNDINQKIAKQILSKYNNGMSAEAIAKAEHVSV EDVNTIIKDNEKVLV*" /label="yqzD CDS" gene 2272572..2272925 /gene="yqzD" /locus_tag="BSU_24930" /old_locus_tag="BSU24930" /label="yqzD gene" CDS 2272922..2273386 /gene="yqzC" /locus_tag="BSU_24940" /old_locus_tag="BSU24940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390373.2" /db_xref="EnsemblGenomes-Gn:BSU24940" /db_xref="EnsemblGenomes-Tr:CAB14424" /db_xref="InterPro:IPR003770" /db_xref="SubtiList:BG13769" /db_xref="UniProtKB/Swiss-Prot:O32023" /translation="MTKRGIQAFAGGIILATAVLAAVFYLTDEDQAAAVKDNKTVTEQ DVNNYLDSKKLVSVNRDEYQKLLDSKEKSLNNDSGSDTKSDKVKTYKLTIKDGMSTAD VSAILEKEGIISSAQDFNDYVIDAGYHKEIRAGEFKVKSDMSFKKIVKTLTR*" /label="yqzC CDS" gene 2272922..2273386 /gene="yqzC" /locus_tag="BSU_24940" /old_locus_tag="BSU24940" /label="yqzC gene" downshifts 2273372 /Source="Nicolas_upshifts" /id="D1293" /incds=0 /nref=216 /ntot=264 /MaxReadThrough="0.9847" /MaxDrop="6.07831" /score="21.2108939" /energy="-8.8" /TU="NA" /idTUdmin="U1934" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2273415..2274197) /gene="pstBB" /locus_tag="BSU_24950" /old_locus_tag="BSU24950" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8760913, 9098050, 12897025, 15289558" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8760913, 9098050, 12897025, 15289558; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphate ABC transporter (ATP-binding protein)" /protein_id="NP_390374.1" /db_xref="EnsemblGenomes-Gn:BSU24950" /db_xref="EnsemblGenomes-Tr:CAB14425" /db_xref="GOA:P46342" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR005670" /db_xref="InterPro:IPR015850" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11379" /db_xref="UniProtKB/Swiss-Prot:P46342" /translation="MSIATEAVMKQEVYQVNGMNLWYGQHHALKNINLSIYENEVTAI IGPSGCGKSTFIKTLNLMIQMTPNVKLAGELNYNGSNILKDKVDIVDLRKNIGMVFQK GNPFPQSIFDNVAYGPRVHGTKNKKKLQEIVEKSLKDVALWDEVKDRLHTSALSLSGG QQQRLCIARALATNPDILLMDEPTSALDPISTRKIEELILELKDKYTIVIVTHNMQQA ARVSDQTAFFYMGELVECDNTNKMFSNPKDQRTLDYISGKFG*" /label="pstBB CDS" gene complement(2273415..2274197) /gene="pstBB" /locus_tag="BSU_24950" /old_locus_tag="BSU24950" /label="pstBB gene" downshifts complement(2273426) /Source="Nicolas_upshifts" /id="D1294" /incds=0 /nref=20 /ntot=46 /MaxReadThrough="2.29658" /MaxDrop="6.53816" /score="26.1659198" /energy="-8.8" /TU="NA" /idTUdmin="U1937" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2274208..2275017) /gene="pstBA" /locus_tag="BSU_24960" /old_locus_tag="BSU24960" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8760913, 9098050, 12897025, 15289558" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8760913, 9098050, 12897025, 15289558; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphate ABC transporter (ATP-binding protein)" /protein_id="NP_390375.1" /db_xref="EnsemblGenomes-Gn:BSU24960" /db_xref="EnsemblGenomes-Tr:CAB14426" /db_xref="GOA:P46341" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR005670" /db_xref="InterPro:IPR015850" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11378" /db_xref="UniProtKB/Swiss-Prot:P46341" /translation="MSEQMVKEKPERAVIVPKQNHVLEVKDLSIYYGNKQAVHHVNMD IEKNAVTALIGPSGCGKSTFLRNINRMNDLIPSARAEGEILYEGLNILGGNINVVSLR REIGMVFQKPNPFPKSIYANITHALKYAGERNKAVLDEIVEESLTKAALWDEVKDRLH SSALSLSGGQQQRLCIARTLAMKPAVLLLDEPASALDPISNAKIEELITGLKREYSII IVTHNMQQALRVSDRTAFFLNGELVEYGQTEQIFTSPKKQKTEDYINGKFG*" /label="pstBA CDS" gene complement(2274208..2275017) /gene="pstBA" /locus_tag="BSU_24960" /old_locus_tag="BSU24960" /label="pstBA gene" CDS complement(2275038..2275922) /gene="pstA" /locus_tag="BSU_24970" /old_locus_tag="BSU24970" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9098050, 12897025, 15289558, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9098050, 12897025, 15289558, 15849754, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="phosphate ABC transporter (permease)" /protein_id="NP_390376.2" /db_xref="EnsemblGenomes-Gn:BSU24970" /db_xref="EnsemblGenomes-Tr:CAB14427" /db_xref="GOA:P46340" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR005672" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11377" /db_xref="UniProtKB/Swiss-Prot:P46340" /translation="MNRKITDKLATGMFGLCAAIIAAILVGLFSYIIINGVSQLSFQF ITTKSSAIAAGGGIRDQLFNSFYILFITMLITIPLGVGGGVFMAEYAPNNKVTDFIRT CIEVLSSLPSIVIGMFGLLMFVNLTGWGYTIIGGALALTVFNLPVMVRVTEDAIRSVP KDLKEASLALGVSRWHTVKTVLIPSAIPSIITGAILASGRVFGEAAALLFTAGLTTPR LNFTEWNPFSETSPLNIFRPAETLAVHIWNVNTQGMIPDAEAIANGGSAVLVISVLVF NLAARWLGTMIYKKLTAN*" /label="pstA CDS" gene complement(2275038..2275922) /gene="pstA" /locus_tag="BSU_24970" /old_locus_tag="BSU24970" /label="pstA gene" CDS complement(2275922..2276851) /gene="pstC" /locus_tag="BSU_24980" /old_locus_tag="BSU24980" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9098050, 12897025, 15289558, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9098050, 12897025, 15289558, 15849754, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="phosphate ABC transporter (permease)" /protein_id="NP_390377.2" /db_xref="EnsemblGenomes-Gn:BSU24980" /db_xref="EnsemblGenomes-Tr:CAB14428" /db_xref="GOA:P46339" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR011864" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11376" /db_xref="UniProtKB/Swiss-Prot:P46339" /translation="MINNRENMSVSERLISSRQNRQLDEVRGRMIVTACALIMIAASV AITIFLGVKGLQSFLVNGVSPIEFLTSLNWNPTDSDPKYGVLPFIFGSFAVTILSALI AAPLGIAGAIFMTEIAPNWGKKVLQPVIELLVGIPSVVYGFIGLTVLVPFIAQFKSSG TGHSLLAGTIVLSVMILPTITSISADAMASLPKSLREGSYALGATRWQTIRKVLVPAA FPTLMTAVVLGMARAFGEALAVQMVIGNTRVLPESPFDTAGTLTTIITLNMGHTTYGS VENNTLWSMGLVLLVMSFLFILLIRYLSSRRKV*" /label="pstC CDS" gene complement(2275922..2276851) /gene="pstC" /locus_tag="BSU_24980" /old_locus_tag="BSU24980" /label="pstC gene" CDS complement(2276920..2277822) /gene="pstS" /locus_tag="BSU_24990" /old_locus_tag="BSU24990" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9098050, 9593301, 10913081, 15289558, 21461370, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9098050, 9593301, 10913081, 15289558, 21461370, 25355936; Product type t : transporter" /codon_start=1 /transl_table=11 /product="phosphate ABC transporter (phosphate binding lipoprotein)" /protein_id="NP_390378.1" /db_xref="EnsemblGenomes-Gn:BSU24990" /db_xref="EnsemblGenomes-Tr:CAB14429" /db_xref="GOA:P46338" /db_xref="InterPro:IPR011862" /db_xref="InterPro:IPR024370" /db_xref="SubtiList:BG11375" /db_xref="UniProtKB/Swiss-Prot:P46338" /translation="MKKNKLVLMLLMAAFMMIAAACGNAGESKKSNSDSAKGEEKASG SLTISGSSAMQPLVLAAAEKFMEENPDADIQVQAGGSGTGLSQVSEGAVQIGNSDVFA EEKEGIDAKALVDHQVAVVGMAAAVNPDAGVKDISKDELKKIFTGKIKNWKELGGKDQ KITLVNRPDSSGTRATFVKYALDGAEPAEGITEDSSNTVKKIIADTPGAIGYLAFSYL TDDKVTALSIDGVKPEAKNVATGEYPIWAYQHSYTKGEATGLAKEFLDYLKSEDIQKS IVTDQGYIPVTDMKVTRDANGKQS*" /label="pstS CDS" gene complement(2276920..2277822) /gene="pstS" /locus_tag="BSU_24990" /old_locus_tag="BSU24990" /label="pstS gene" upshifts complement(2277877) /Source="Nicolas_upshifts" /id="U1937" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.977022977022977" /psig="0.014985014985015" /xcortree=7 /SigmaFactorBS="aaaaaacgcactgatttacaaaaCCTtaacattcggTTCAAA CCCTTTTTACAtagaacctttactctatacgtgtaggacaaattacacattatacgca g" /listShort="pstS, pstC, pstA, pstBA, pstBB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2277885..2277901) /Source="Nicolas_upshift_promotors" /id="U1937" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.977022977022977" /psig="0.014985014985015" /xcortree=7 /SigmaFactorBS="aaaaaacgcactgatttacaaaaCCTtaacattcggTTCAAA CCCTTTTTACAtagaacctttactctatacgtgtaggacaaattacacattatacgca g" /listShort="pstS, pstC, pstA, pstBA, pstBB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2277912..2277914) /Source="Nicolas_upshift_promotors" /id="U1937" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.977022977022977" /psig="0.014985014985015" /xcortree=7 /SigmaFactorBS="aaaaaacgcactgatttacaaaaCCTtaacattcggTTCAAA CCCTTTTTACAtagaacctttactctatacgtgtaggacaaattacacattatacgca g" /listShort="pstS, pstC, pstA, pstBA, pstBB" /GFF_Attribute="listLong" /label="promotor_-35" Polymorphism join(2277931,2277933) /Source="geneious" /ID="SNP_BsDelta6_2581727_2581726" /Polymorphism_Type="Insertion (tandem repeat)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=0 /Amino_Acid_Change /CDS_Position /Change="(T)6 -> (T)7" /Codon_Change /Coverage=117 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides /Variant_Nucleotides="T" /Variant_P_Value=0 /Variant_Raw_Frequency=114 /comment="-" /modified_by="User" / /label="Polymorphism_Delta6" CDS complement(2277977..2280127) /gene="pbpA" /locus_tag="BSU_25000" /old_locus_tag="BSU25000" /EC_number="3.4.-.-" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9139922, 9851991, 12896990, 17307860" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9139922, 9851991, 12896990, 17307860; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="transpeptidase (penicillin-binding protein 2A)" /protein_id="NP_390379.1" /db_xref="EnsemblGenomes-Gn:BSU25000" /db_xref="EnsemblGenomes-Tr:CAB14430" /db_xref="GOA:P54488" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR005311" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR036138" /db_xref="SubtiList:BG11678" /db_xref="UniProtKB/Swiss-Prot:P54488" /translation="MRRNKPKKQNHKEKKKSLPIRLNILFLAAFVIFTWIIVELGIKQ IVQGDDYKNQANKQEQSEVSSAVPRGKIYDRNFNAIVTNKALNAITYTRSKSTTQEQR LKIAKKLSDMIKVDTKKVTERDKKDYWILTRPKEAKKLISSKERQQVEDKKISDDDLY QLQLKRITDKQLNELTDKDMQILAIKRQMDSGYALTPQYIKNEDVSAKEMAVVSEHLD ELPGVDVTSDWEREYPYKNLLRSVLGSVSSSNEGLPSNLLDHYLSLGYSRNDRVGKSY LEYQYESLLQGQKAKVENITDSKGNVTGTKTVSEGKAGKDLVLTIDIDLQKSVEKIIE KKLKAAKARPSTELLDRAFVVMMDPRNGEVLTMAGKQIKRENGAYKFDDYALGAMTSS YAMGSAVKGATVLTGLQTGAINLNTVFKDEPLYIGQDKRGKKSWQNLGPVGIQTALEK SSNVFMFKTAIAVGKGEYKPHQALPLDTSAFDTFRNYFSQFGLGVKTGIDLPNEMTGY KGTSRLSGFLLDFAIGQYDTYTPLELAQYVSTIANGGYRMKPQLVKEVRDSNAKKGIG AVVDSVQPEVLNKVDMKSSYIEEVQAGFRRVATKGTAAGQLASASYKPAAKTGTAQSF YDGPDKSKTGTDTYNTTLVAYAPADNPEIAISVVVPWTYIDYNQRYSITNEIGREVMD KYFELKSKQDKEGTQQKNKDKIEENAENTTSSDN*" /label="pbpA CDS" gene complement(2277977..2280127) /gene="pbpA" /locus_tag="BSU_25000" /old_locus_tag="BSU25000" /label="pbpA gene" downshifts complement(2277987) /Source="Nicolas_upshifts" /id="D1295" /incds=0 /nref=255 /ntot=278 /MaxReadThrough="1.22121" /MaxDrop="8.82988" /score="31.2726004" /energy="-10" /TU="U1940" /idTUdmin="U1938" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2278721..2278739) /Source="Nicolas_upshift_promotors" /id="U1938" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=129 /SigmaFactorBS="gcattagagaagtcatcaaacgtttttaTGTTTAAaacagca attgcagtTGGTAAAGGTGAATATAAAcctcaccaagcattgcctttggatacttctg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2278729) /Source="Nicolas_upshifts" /id="U1938" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=129 /SigmaFactorBS="gcattagagaagtcatcaaacgtttttaTGTTTAAaacagca attgcagtTGGTAAAGGTGAATATAAAcctcaccaagcattgcctttggatacttctg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2278755..2278761) /Source="Nicolas_upshift_promotors" /id="U1938" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=129 /SigmaFactorBS="gcattagagaagtcatcaaacgtttttaTGTTTAAaacagca attgcagtTGGTAAAGGTGAATATAAAcctcaccaagcattgcctttggatacttctg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2279416..2279435) /Source="Nicolas_upshift_promotors" /id="U1939" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1230 /SigmaFactorBS="tggtaagtgaacatttagacgaactgccaggtgttGATGTCA CGTccgattgggaacgTGAATATCCTTATAAAAACCttcttcgctcagtgctcggaag t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2279433) /Source="Nicolas_upshifts" /id="U1939" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1230 /SigmaFactorBS="tggtaagtgaacatttagacgaactgccaggtgttGATGTCA CGTccgattgggaacgTGAATATCCTTATAAAAACCttcttcgctcagtgctcggaag t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2279449..2279458) /Source="Nicolas_upshift_promotors" /id="U1939" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1230 /SigmaFactorBS="tggtaagtgaacatttagacgaactgccaggtgttGATGTCA CGTccgattgggaacgTGAATATCCTTATAAAAACCttcttcgctcagtgctcggaag t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2280177..2280196) /Source="Nicolas_upshift_promotors" /id="U1940" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.773226773226773" /psig="0.994005994005994" /xcortree=2518 /SigmaFactorBS="aatttttttgccaaaaaggggttatcTGTAGaaaaaagtcga aaaaACCTTTAAAATGAAAACTGGcactcttacttgagtgtcttttctttctgtaaat a" /listShort="pbpA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2280182) /Source="Nicolas_upshifts" /id="U1940" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.773226773226773" /psig="0.994005994005994" /xcortree=2518 /SigmaFactorBS="aatttttttgccaaaaaggggttatcTGTAGaaaaaagtcga aaaaACCTTTAAAATGAAAACTGGcactcttacttgagtgtcttttctttctgtaaat a" /listShort="pbpA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2280212..2280216) /Source="Nicolas_upshift_promotors" /id="U1940" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.773226773226773" /psig="0.994005994005994" /xcortree=2518 /SigmaFactorBS="aatttttttgccaaaaaggggttatcTGTAGaaaaaagtcga aaaaACCTTTAAAATGAAAACTGGcactcttacttgagtgtcttttctttctgtaaat a" /listShort="pbpA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2280241..2281533) /gene="yqgE" /locus_tag="BSU_25010" /old_locus_tag="BSU25010" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10960106, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_390380.2" /db_xref="EnsemblGenomes-Gn:BSU25010" /db_xref="EnsemblGenomes-Tr:CAB14431" /db_xref="GOA:P54487" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11677" /db_xref="UniProtKB/Swiss-Prot:P54487" /translation="MSKLKKVIGDVDVNKGLLFLLTIGGLYSLGIALSNTFVNVYLWK QSGKFIDLAIYNLSIVTMQPITFYLAGRLAKKIDRVFILRFGVIFLAAFYLSVLLAGE TAASRLVLIGAVLGVGYGFYWLAFNVLTFEITEPDTRDFFNGFMGILSSSAGMIGPIV AGFVISRLENNTGYTVIFSLSLSLFALAVVMSFFLKRRESKGRFMLSKVFGERHSNMN WRRITNAHFFQGLREGIFVFLISVFVFIETNSELALGTFGLVNSAVSFFAYYFASRLI KKKARKKSILLGGLILYGALFLILFHMSFSTLLTYGVFIAIGYPLLLVPYVSLTYDVI GRARHARKARIEYIVLREMFLNAGRIVSILCFLLIVALLKEDVGIPLSLAILGIGHPL IYYFVKDIRFKEKEGENETMEEDGQKRVTEPTLLKGER*" /label="yqgE CDS" gene complement(2280241..2281533) /gene="yqgE" /locus_tag="BSU_25010" /old_locus_tag="BSU25010" /label="yqgE gene" promotor_-10 complement(2281556..2281567) /Source="Nicolas_upshift_promotors" /id="U1941" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=934 /SigmaFactorBS="ggtcctcattatgggaccttgtttttttatgtcttcttttTA CATATctcggtttgagtgAGACAGACTAAGggatagtaaaggggagtcagtaatgagc a" /listShort="yqgE, pbpA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2281567) /Source="Nicolas_upshifts" /id="U1941" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=934 /SigmaFactorBS="ggtcctcattatgggaccttgtttttttatgtcttcttttTA CATATctcggtttgagtgAGACAGACTAAGggatagtaaaggggagtcagtaatgagc a" /listShort="yqgE, pbpA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2281581..2281587) /Source="Nicolas_upshift_promotors" /id="U1941" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=934 /SigmaFactorBS="ggtcctcattatgggaccttgtttttttatgtcttcttttTA CATATctcggtttgagtgAGACAGACTAAGggatagtaaaggggagtcagtaatgagc a" /listShort="yqgE, pbpA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2281640..2282248) /gene="sodA" /locus_tag="BSU_25020" /old_locus_tag="BSU25020" /EC_number="1.15.1.1" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9393707, 9573176, 9658017, 10074093, 15897454, 18084079, 25445927" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9393707, 9573176, 9658017, 10074093, 15897454, 18084079, 25445927; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="superoxide dismutase (Mn[2+]-dependent)" /protein_id="NP_390381.3" /db_xref="EnsemblGenomes-Gn:BSU25020" /db_xref="EnsemblGenomes-Tr:CAB14432" /db_xref="GOA:P54375" /db_xref="InterPro:IPR001189" /db_xref="InterPro:IPR019831" /db_xref="InterPro:IPR019832" /db_xref="InterPro:IPR019833" /db_xref="InterPro:IPR036314" /db_xref="InterPro:IPR036324" /db_xref="PDB:2RCV" /db_xref="SubtiList:BG11676" /db_xref="UniProtKB/Swiss-Prot:P54375" /translation="MAYELPELPYAYDALEPHIDKETMTIHHTKHHNTYVTNLNKAVE GNTALANKSVEELVADLDSVPENIRTAVRNNGGGHANHKLFWTLLSPNGGGEPTGALA EEINSVFGSFDKFKEQFAAAAAGRFGSGWAWLVVNNGKLEITSTPNQDSPLSEGKTPI LGLDVWEHAYYLNYQNRRPDYISAFWNVVNWDEVARLYSEAK*" /label="sodA CDS" gene complement(2281640..2282248) /gene="sodA" /locus_tag="BSU_25020" /old_locus_tag="BSU25020" /label="sodA gene" downshifts complement(2281655) /Source="Nicolas_upshifts" /id="D1296" /incds=0 /nref=265 /ntot=268 /MaxReadThrough="4.329" /MaxDrop="9.16338" /score="3.26408916" /energy="-8.1" /TU="U1943" /idTUdmin="U1942" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2282300..2282319) /Source="Nicolas_upshift_promotors" /id="U1942" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.671328671328671" /psig="0.998001998001998" /xcortree=102 /SigmaFactorBS="cgctgaaatgagccaaatcgtgagctttttCATTGATTacaa agcattctttTGTTACATTGAATGAAGAAAggctcgctgtgaagcggcatttcagtac a" /listShort="sodA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2282311) /Source="Nicolas_upshifts" /id="U1942" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.671328671328671" /psig="0.998001998001998" /xcortree=102 /SigmaFactorBS="cgctgaaatgagccaaatcgtgagctttttCATTGATTacaa agcattctttTGTTACATTGAATGAAGAAAggctcgctgtgaagcggcatttcagtac a" /listShort="sodA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2282313..2282381) /Source="Nicolas_S_feature" /locus_tag="new_2586107_2586175_c" /HighExp="Etha, Salt, Heat, LPhT, Gly, Sw, S4, LoTm, M9-stat, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigA" /TUshortPSig="0.997, 1" /TUlongSig="SigB" /TUlongPSig="0.999" /label="S936" promotor_-35 complement(2282334..2282341) /Source="Nicolas_upshift_promotors" /id="U1942" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.671328671328671" /psig="0.998001998001998" /xcortree=102 /SigmaFactorBS="cgctgaaatgagccaaatcgtgagctttttCATTGATTacaa agcattctttTGTTACATTGAATGAAGAAAggctcgctgtgaagcggcatttcagtac a" /listShort="sodA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2282372..2282390) /Source="Nicolas_upshift_promotors" /id="U1943" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=263 /SigmaFactorBS="tggacggtcctataagaaatgctggcggcaGGTTTAAtgggg cagattatcGGTTAAAGTGAAATATGTCcgctgaaatgagccaaatcgtgagcttttt c" /listShort="S936, sodA, yqgE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2282381) /Source="Nicolas_upshifts" /id="U1943" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=263 /SigmaFactorBS="tggacggtcctataagaaatgctggcggcaGGTTTAAtgggg cagattatcGGTTAAAGTGAAATATGTCcgctgaaatgagccaaatcgtgagcttttt c" /listShort="S936, sodA, yqgE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2282405..2282411) /Source="Nicolas_upshift_promotors" /id="U1943" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=263 /SigmaFactorBS="tggacggtcctataagaaatgctggcggcaGGTTTAAtgggg cagattatcGGTTAAAGTGAAATATGTCcgctgaaatgagccaaatcgtgagcttttt c" /listShort="S936, sodA, yqgE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2282427..2282909) /gene="yqgC" /locus_tag="BSU_25030" /old_locus_tag="BSU25030" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406; Product type m:membrane component" /codon_start=1 /transl_table=11 /product="conserved integral inner membrane protein of unknown function" /protein_id="NP_390382.1" /db_xref="EnsemblGenomes-Gn:BSU25030" /db_xref="EnsemblGenomes-Tr:CAB14433" /db_xref="GOA:P54486" /db_xref="InterPro:IPR007403" /db_xref="SubtiList:BG11675" /db_xref="UniProtKB/Swiss-Prot:P54486" /translation="MDMLYWLLIAAVFIIAFIGLVYPVIPSVVFIVAGFVLYGFLFSF SPYSYMFWLVEAVFAAVLFAADYVSNLLGVKRFGGSKAAIWGSTIGLLIGPFVIPVAG IILGPFIGAVCAELIVHQKDLKSAFKIGLGSLIGFLTGVIAKGIIQLLMIGYFLWTVL *" /label="yqgC CDS" gene complement(2282427..2282909) /gene="yqgC" /locus_tag="BSU_25030" /old_locus_tag="BSU25030" /label="yqgC gene" S_feature complement(2282910..2283202) /Source="Nicolas_S_feature" /locus_tag="new_2586704_2586996_c" /HighExp="Etha, Gly, Salt, aero, S0, LoTm, HiTm, LPh, nit, ferm" /AntisenseName="yqgB" /AntisenseCor="9.8584854910492598E-2" /AntisenseRegPval="-1" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigA" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S937" promotor_-35 2282952..2282958 /Source="Nicolas_upshift_promotors" /id="U1944" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.36963036963037" /psig="0.731268731268731" /xcortree=2372 /SigmaFactorBS="ttttactctgtcttcttcatgtcttcCTTGTATtcacacgca tgcaaCGATACAATAAGCAACATATattagtttagctaggaagtgaagatagtgaatg t" /listShort="yqgB, S939" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2282973..2282992 /Source="Nicolas_upshift_promotors" /id="U1944" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.36963036963037" /psig="0.731268731268731" /xcortree=2372 /SigmaFactorBS="ttttactctgtcttcttcatgtcttcCTTGTATtcacacgca tgcaaCGATACAATAAGCAACATATattagtttagctaggaagtgaagatagtgaatg t" /listShort="yqgB, S939" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2282986 /Source="Nicolas_upshifts" /id="U1944" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.36963036963037" /psig="0.731268731268731" /xcortree=2372 /SigmaFactorBS="ttttactctgtcttcttcatgtcttcCTTGTATtcacacgca tgcaaCGATACAATAAGCAACATATattagtttagctaggaagtgaagatagtgaatg t" /listShort="yqgB, S939" /GFF_Attribute="listLong" /label="upshifts" CDS 2283019..2283786 /gene="yqgB" /locus_tag="BSU_25040" /old_locus_tag="BSU25040" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 15294815; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="factor involved in motility" /protein_id="NP_390383.2" /db_xref="EnsemblGenomes-Gn:BSU25040" /db_xref="EnsemblGenomes-Tr:CAB14434" /db_xref="GOA:P54485" /db_xref="InterPro:IPR009574" /db_xref="SubtiList:BG11674" /db_xref="UniProtKB/Swiss-Prot:P54485" /translation="MNVFQLFIKSTYSPRDIAKTRFQGIGKAILYVFLLSVLFAIPTA YYVSTGTVKSMNGFKTVLNKDFPDFTISNGKLQTDEKKATESQANGFVIVFDPTDSYG TEQIEAKQNAIGILQNKFVLAIDGQAQEMSYSMMPSELQKKDVIAGLNQNKAMIVTVL SALIFLVTAAGKFIEVSFLALIGLIIKNSQKKHLSYHQLWKLSAYSITLSTVFFTIMR ALEATVPSEFLLNWFVNFVILFLVLKEIPSKKVINKS*" /label="yqgB CDS" gene 2283019..2283786 /gene="yqgB" /locus_tag="BSU_25040" /old_locus_tag="BSU25040" /label="yqgB gene" promotor_-10 complement(2283200..2283218) /Source="Nicolas_upshift_promotors" /id="U1945" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=174 /SigmaFactorBS="ttttctcatccgtttgaagtttgcCGTTTGAaattgtgaaat caGGGAAATCTTTGTTTAAAAcagttttaaagccgttcattgattttacggtccctgt a" /listShort="S937, yqgC" /listLong="S936, sodA, yqgE" /label="promotor_-10" upshifts complement(2283202) /Source="Nicolas_upshifts" /id="U1945" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=174 /SigmaFactorBS="ttttctcatccgtttgaagtttgcCGTTTGAaattgtgaaat caGGGAAATCTTTGTTTAAAAcagttttaaagccgttcattgattttacggtccctgt a" /listShort="S937, yqgC" /listLong="S936, sodA, yqgE" /label="upshifts" S_feature complement(2283204..2284140) /Source="Nicolas_S_feature" /locus_tag="new_2586998_2587934_c" /HighExp="S0, S1, aero, M0t45, HPh, Lbtran, LPh, GM 120, nit, M/G" /AntisenseName="yqgB" /AntisenseCor="0.31978785018705103" /AntisenseRegPval="-7.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S938" promotor_-35 complement(2283232..2283238) /Source="Nicolas_upshift_promotors" /id="U1945" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=174 /SigmaFactorBS="ttttctcatccgtttgaagtttgcCGTTTGAaattgtgaaat caGGGAAATCTTTGTTTAAAAcagttttaaagccgttcattgattttacggtccctgt a" /listShort="S937, yqgC" /listLong="S936, sodA, yqgE" /label="promotor_-35" S_feature 2283787..2284217 /Source="Nicolas_S_feature" /locus_tag="new_2587581_2588011" /HighExp="C30, HiOs, UNK1, Gly, Fru, S8, Salt, MG 5, S7, MG 25" /AntisenseName="yqgA" /AntisenseCor="0.170248276038857" /AntisenseRegPval="-2.2999999999999998" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.731" /TUlongSig="NA" /TUlongPSig="NA" /label="S939" downshifts 2284174 /Source="Nicolas_upshifts" /id="D1297" /incds=0 /nref=5 /ntot=131 /MaxReadThrough="3.89102" /MaxDrop="3.29021" /score="30.8580926" /energy="-13.8" /TU="U1944" /idTUdmin="U1944" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" downshifts complement(2284185) /Source="Nicolas_upshifts" /id="D1298" /incds=0 /nref=15 /ntot=207 /MaxReadThrough="6.7306" /MaxDrop="3.9194" /score="7.48192829" /energy="-14.3" /TU="U1947" /idTUdmin="U1945" /TUdmin="-1848" /isTUend="FALSE" /label="downshifts" CDS complement(2284202..2284630) /gene="yqgA" /locus_tag="BSU_25050" /old_locus_tag="BSU25050" /experiment="publication(s) with functional evidences, PMID:25130749, 27797724" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25130749, 27797724; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="cell wall protein" /protein_id="NP_390384.2" /db_xref="EnsemblGenomes-Gn:BSU25050" /db_xref="EnsemblGenomes-Tr:CAB14435" /db_xref="GOA:P54484" /db_xref="SubtiList:BG11673" /db_xref="UniProtKB/Swiss-Prot:P54484" /translation="MKQGKFSVFLILLLMLTLVVAPKEKAEAASSGWQPVSGISGCKI RVITDAYTYTKSATSIDAYAETNGKCGKLNYKSFGVSIVEGGDIGPQYSGYFSSRTPT KKFYFSKLPKPTGTPWAVGLSVYKGKAKGAAFVYINPQKR*" /label="yqgA CDS" gene complement(2284202..2284630) /gene="yqgA" /locus_tag="BSU_25050" /old_locus_tag="BSU25050" /label="yqgA gene" promotor_-35 2284626..2284630 /Source="Nicolas_upshift_promotors" /id="U1946" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=294 /SigmaFactorBS="tagtagcaaaattaaaaacacagaaaattttccttgcTTCAT tttgtagatCCTCCTTTAAACTATtacataattatcctaacagatccattgttcattg t" /listShort="yqfZ" /listLong="S940, ispG" /label="promotor_-35" promotor_-10 2284640..2284654 /Source="Nicolas_upshift_promotors" /id="U1946" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=294 /SigmaFactorBS="tagtagcaaaattaaaaacacagaaaattttccttgcTTCAT tttgtagatCCTCCTTTAAACTATtacataattatcctaacagatccattgttcattg t" /listShort="yqfZ" /listLong="S940, ispG" /label="promotor_-10" upshifts 2284649 /Source="Nicolas_upshifts" /id="U1946" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=294 /SigmaFactorBS="tagtagcaaaattaaaaacacagaaaattttccttgcTTCAT tttgtagatCCTCCTTTAAACTATtacataattatcctaacagatccattgttcattg t" /listShort="yqfZ" /listLong="S940, ispG" /label="upshifts" promotor_-10 complement(2284653..2284672) /Source="Nicolas_upshift_promotors" /id="U1947" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2294 /SigmaFactorBS="agatcaaaaagaggcttttataatataaaactcgtattccat TATTTACAatgaacaatggatcTGTTAGGATAATTATGTAATagtttaaaggaggatc t" /listShort="yqgA, S938, S937, yqgC, S936" /listLong="sodA" /label="promotor_-10" upshifts complement(2284676) /Source="Nicolas_upshifts" /id="U1947" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2294 /SigmaFactorBS="agatcaaaaagaggcttttataatataaaactcgtattccat TATTTACAatgaacaatggatcTGTTAGGATAATTATGTAATagtttaaaggaggatc t" /listShort="yqgA, S938, S937, yqgC, S936" /listLong="sodA" /label="upshifts" promotor_-35 complement(2284687..2284694) /Source="Nicolas_upshift_promotors" /id="U1947" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2294 /SigmaFactorBS="agatcaaaaagaggcttttataatataaaactcgtattccat TATTTACAatgaacaatggatcTGTTAGGATAATTATGTAATagtttaaaggaggatc t" /listShort="yqgA, S938, S937, yqgC, S936" /listLong="sodA" /label="promotor_-35" promotor_-35 2284845..2284850 /Source="Nicolas_upshift_promotors" /id="U1948" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=967 /SigmaFactorBS="ccgagcattcgcagtctcttttcttttGTCATGaatcgaaat ggacaaGCATACTATGGTATAAAATttcgtatgcgggaggaaaagcgatgaagcgtct c" /listShort="yqfZ, S940, ispG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2284866..2284884 /Source="Nicolas_upshift_promotors" /id="U1948" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=967 /SigmaFactorBS="ccgagcattcgcagtctcttttcttttGTCATGaatcgaaat ggacaaGCATACTATGGTATAAAATttcgtatgcgggaggaaaagcgatgaagcgtct c" /listShort="yqfZ, S940, ispG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2284878 /Source="Nicolas_upshifts" /id="U1948" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=967 /SigmaFactorBS="ccgagcattcgcagtctcttttcttttGTCATGaatcgaaat ggacaaGCATACTATGGTATAAAATttcgtatgcgggaggaaaagcgatgaagcgtct c" /listShort="yqfZ, S940, ispG" /GFF_Attribute="listLong" /label="upshifts" CDS 2284907..2285206 /gene="yqfZ" /locus_tag="BSU_25060" /old_locus_tag="BSU25060" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15294815; Product type ph : phenotype" /codon_start=1 /transl_table=11 /product="factor involved in motility" /protein_id="NP_390385.1" /db_xref="EnsemblGenomes-Gn:BSU25060" /db_xref="EnsemblGenomes-Tr:CAB14436" /db_xref="GOA:P54483" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR020506" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG11672" /db_xref="UniProtKB/Swiss-Prot:P54483" /translation="MKRLTLVCSIVFILFILFYDLKIGTIPIQDLPVYEASAKTAVQE PAYKTVKVKPGDTVMSIVGSAGSPDDIVKDFEALNPNVKANAIQAGTAYKFPVYP*" /label="yqfZ CDS" gene 2284907..2285206 /gene="yqfZ" /locus_tag="BSU_25060" /old_locus_tag="BSU25060" /label="yqfZ gene" promotor_-35 2285219..2285226 /Source="Nicolas_upshift_promotors" /id="U1949" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.613386613386613" /psig="0.999000999001" /xcortree=1976 /SigmaFactorBS="ccggtctacccttaatttaacgttaatTTCTTGTCagttcgg cgaagacACTGTTACAATGTAATTTGTaaaataaattcacataaaccatactagaatt g" /listShort="S940, ispG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2285241..2285260 /Source="Nicolas_upshift_promotors" /id="U1949" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.613386613386613" /psig="0.999000999001" /xcortree=1976 /SigmaFactorBS="ccggtctacccttaatttaacgttaatTTCTTGTCagttcgg cgaagacACTGTTACAATGTAATTTGTaaaataaattcacataaaccatactagaatt g" /listShort="S940, ispG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2285252..2285328 /Source="Nicolas_S_feature" /locus_tag="new_2589046_2589122" /HighExp="Diami, dia5, dia15, H2O2, Etha, Salt, LBGexp, Oxctl, Paraq, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="0.999, 1" /TUlongSig="Sig-" /TUlongPSig=0 /label="S940" upshifts 2285252 /Source="Nicolas_upshifts" /id="U1949" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.613386613386613" /psig="0.999000999001" /xcortree=1976 /SigmaFactorBS="ccggtctacccttaatttaacgttaatTTCTTGTCagttcgg cgaagacACTGTTACAATGTAATTTGTaaaataaattcacataaaccatactagaatt g" /listShort="S940, ispG" /GFF_Attribute="listLong" /label="upshifts" CDS 2285329..2286462 /gene="ispG" /locus_tag="BSU_25070" /old_locus_tag="BSU25070" /EC_number="1.17.7.1" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12571359, 16268586, 25212876; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase (1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase)" /protein_id="NP_390386.1" /db_xref="EnsemblGenomes-Gn:BSU25070" /db_xref="EnsemblGenomes-Tr:CAB14437" /db_xref="GOA:P54482" /db_xref="InterPro:IPR004588" /db_xref="InterPro:IPR011005" /db_xref="InterPro:IPR016425" /db_xref="InterPro:IPR036849" /db_xref="SubtiList:BG11671" /db_xref="UniProtKB/Swiss-Prot:P54482" /translation="MQVSEITHRTKTRPVKVGPLTIGGNNEVVIQSMTTTKTHDVEAT VAEINRLAEAGCQIVRVACPDERAANAIADIKKRISIPLVVDIHFDYKLALKAIEGGA DKIRINPGNIGRREKVEAVVKAAKDKGIPIRIGVNAGSLEKRILEKYGYPTADGMVES ALHHIKILEDLDFHDIIVSMKASDVNLAIEAYEKAAKAFDYPLHLGITESGTLFAGTV KSAAGLGAILSKGIGNTMRISLSADPVEEVKVARELLKSFGLASNAATLISCPTCGRI EIDLISIANEVEEYISKIKAPIKVAVLGCAVNGPGEAREADIGIAGARGEGLLFRKGK IVRKVPEETMVEELKKEIDILAEEHYAKLEAEKAKLKEETQKA*" /label="ispG CDS" gene 2285329..2286462 /gene="ispG" /locus_tag="BSU_25070" /old_locus_tag="BSU25070" /label="ispG gene" downshifts 2286443 /Source="Nicolas_upshifts" /id="D1299" /incds=0 /nref=230 /ntot=267 /MaxReadThrough="2.62035" /MaxDrop="8.92434" /score="30.8580926" /energy="-13.8" /TU="NA" /idTUdmin="U1948" /TUdmin=3 /isTUend="TRUE" /label="downshifts" CDS complement(2286488..2286877) /gene="yqfX" /locus_tag="BSU_25080" /old_locus_tag="BSU25080" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 17322312, 22882546" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function expressed in germinating spores" /protein_id="NP_390387.1" /db_xref="EnsemblGenomes-Gn:BSU25080" /db_xref="EnsemblGenomes-Tr:CAB14438" /db_xref="GOA:P54481" /db_xref="SubtiList:BG11670" /db_xref="UniProtKB/Swiss-Prot:P54481" /translation="MKVANDYEKRDNNSYYVDHGSEGTNITRDNDGFFEETAAEIAEP YRAADRSNDQDNDRSGGNVNEGRGIGYIALALSIISLFVLPVLLGAAGIIVGYIARRR GAQGLGAWAMGIGVVSLVLGIFIIPFF*" /label="yqfX CDS" gene complement(2286488..2286877) /gene="yqfX" /locus_tag="BSU_25080" /old_locus_tag="BSU25080" /label="yqfX gene" downshifts complement(2286514) /Source="Nicolas_upshifts" /id="D1300" /incds=0 /nref=10 /ntot=62 /MaxReadThrough="1.85077" /MaxDrop="8.74353" /score="28.1764525" /energy="-13.8" /TU="NA" /idTUdmin="U1950" /TUdmin=2 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2286908..2286919) /Source="Nicolas_upshift_promotors" /id="U1950" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=841 /SigmaFactorBS="ataaacaattgacattaacagaaaagtttagcaAACATGAat caggcaaaatgGATCAAACTATAaaagctcctttaataaaacagaagggggaattgaa g" /listShort="yqfX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2286912) /Source="Nicolas_upshifts" /id="U1950" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=841 /SigmaFactorBS="ataaacaattgacattaacagaaaagtttagcaAACATGAat caggcaaaatgGATCAAACTATAaaagctcctttaataaaacagaagggggaattgaa g" /listShort="yqfX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2286933..2286939) /Source="Nicolas_upshift_promotors" /id="U1950" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=841 /SigmaFactorBS="ataaacaattgacattaacagaaaagtttagcaAACATGAat caggcaaaatgGATCAAACTATAaaagctcctttaataaaacagaagggggaattgaa g" /listShort="yqfX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2286952..2286959 /Source="Nicolas_upshift_promotors" /id="U1951" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.971028971028971" /psig="0.999000999001" /xcortree=587 /SigmaFactorBS="agtttgatccattttgcctgattcatgtttgctaaacttttC TGTTAATgtcaattgttTATGTTACACTTGAAGGGATgaaactgaaggagtgtgggca t" /listShort="yqfW, S941" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2286970..2286989 /Source="Nicolas_upshift_promotors" /id="U1951" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.971028971028971" /psig="0.999000999001" /xcortree=587 /SigmaFactorBS="agtttgatccattttgcctgattcatgtttgctaaacttttC TGTTAATgtcaattgttTATGTTACACTTGAAGGGATgaaactgaaggagtgtgggca t" /listShort="yqfW, S941" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2286971 /Source="Nicolas_upshifts" /id="U1951" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.971028971028971" /psig="0.999000999001" /xcortree=587 /SigmaFactorBS="agtttgatccattttgcctgattcatgtttgctaaacttttC TGTTAATgtcaattgttTATGTTACACTTGAAGGGATgaaactgaaggagtgtgggca t" /listShort="yqfW, S941" /GFF_Attribute="listLong" /label="upshifts" CDS 2287010..2287591 /gene="yqfW" /locus_tag="BSU_25090" /old_locus_tag="BSU25090" /EC_number="3.1.3.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative nucleotidase" /protein_id="NP_390388.1" /db_xref="EnsemblGenomes-Gn:BSU25090" /db_xref="EnsemblGenomes-Tr:CAB14439" /db_xref="GOA:P54480" /db_xref="InterPro:IPR009206" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG11669" /db_xref="UniProtKB/Swiss-Prot:P54480" /translation="MLRLGIDIDGTITAQDTFVPYLNRSFNLSISLNDMTDYDLTKLL NITQEEFWDWMNQNEAIIYKEALLAQHAKQSLDLLKEEHKLIYITARRTHLTDITYEW FDRQNIHYDHIELVGGHHKVEAVKNHNIDLFFEDHHGNAMMIAKEAGIPVILFNSPYN QLPIDSNIIRVNNWLEAVQWMNNNKHHLIRVNN*" /label="yqfW CDS" gene 2287010..2287591 /gene="yqfW" /locus_tag="BSU_25090" /old_locus_tag="BSU25090" /label="yqfW gene" downshifts 2287589 /Source="Nicolas_upshifts" /id="D1301" /incds=0 /nref=34 /ntot=240 /MaxReadThrough="4.07255" /MaxDrop="4.44714" /score="-2.90660182" /energy="-8" /TU="U1951" /idTUdmin="U1951" /TUdmin="-611" /isTUend="FALSE" /label="downshifts" S_feature 2287634..2288242 /Source="Nicolas_S_feature" /locus_tag="new_2591428_2592036" /HighExp="LoTm, S8, Cold, S7, S5, Sw, BC, S6, HiOs, B60" /AntisenseName="zur" /AntisenseCor="-0.265512398914523" /AntisenseRegPval="-5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S941" CDS complement(2287634..2288071) /gene="zur" /locus_tag="BSU_25100" /old_locus_tag="BSU25100" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12180919, 12426338, 12904577, 17216355, 21821657, 25213752, 27561249, 28104400" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12180919, 12426338, 12904577, 17216355, 21821657, 25213752, 27561249, 28104400; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (Zn[2+]-binding Fur family)" /protein_id="NP_390389.2" /db_xref="EnsemblGenomes-Gn:BSU25100" /db_xref="EnsemblGenomes-Tr:CAB14440" /db_xref="GOA:P54479" /db_xref="InterPro:IPR002481" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11668" /db_xref="UniProtKB/Swiss-Prot:P54479" /translation="MNVQEALNLLKENGYKYTNKREDMLQLFADSDRYLTAKNVLSAL NDDYPGLSFDTIYRNLSLYEELGILETTELSGEKLFRFKCSFTHHHHHFICLACGKTK EIESCPMDKLCDDLDGYQVSGHKFEIYGTCPDCTAENQENTTA*" /label="zur CDS" gene complement(2287634..2288071) /gene="zur" /locus_tag="BSU_25100" /old_locus_tag="BSU25100" /label="zur gene" downshifts complement(2287638) /Source="Nicolas_upshifts" /id="D1302" /incds=0 /nref=181 /ntot=243 /MaxReadThrough="2.37371" /MaxDrop="6.74703" /score="16.4418277" /energy="-11.9" /TU="U1956" /idTUdmin="U1952" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2288072..2288166) /Source="Nicolas_S_feature" /locus_tag="new_2591866_2591960_c" /HighExp="LPhT, G180, Cold, LBGstat, H2O2, Oxctl, G135, G150, HPh, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S942" promotor_-10 complement(2288162..2288181) /Source="Nicolas_upshift_promotors" /id="U1952" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.428571428571429" /psig=1 /xcortree=2760 /SigmaFactorBS="aaaaacgcaatccactaggctttCATTTACTtttattcattt tatGGGTATAATTTTATCTGCAGtaaagaaaatggcttgctggacagacagctgccat t" /listShort="S942, zur" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2288166) /Source="Nicolas_upshifts" /id="U1952" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.428571428571429" /psig=1 /xcortree=2760 /SigmaFactorBS="aaaaacgcaatccactaggctttCATTTACTtttattcattt tatGGGTATAATTTTATCTGCAGtaaagaaaatggcttgctggacagacagctgccat t" /listShort="S942, zur" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2288196..2288203) /Source="Nicolas_upshift_promotors" /id="U1952" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.428571428571429" /psig=1 /xcortree=2760 /SigmaFactorBS="aaaaacgcaatccactaggctttCATTTACTtttattcattt tatGGGTATAATTTTATCTGCAGtaaagaaaatggcttgctggacagacagctgccat t" /listShort="S942, zur" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2288209..2289090) /gene="yqfU" /locus_tag="BSU_25110" /old_locus_tag="BSU25110" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390390.2" /db_xref="EnsemblGenomes-Gn:BSU25110" /db_xref="EnsemblGenomes-Tr:CAB14441" /db_xref="GOA:P54478" /db_xref="InterPro:IPR003740" /db_xref="InterPro:IPR019264" /db_xref="SubtiList:BG11667" /db_xref="UniProtKB/Swiss-Prot:P54478" /translation="MTPTKQHKKETFTHFIFRVFMILVGAASAAVSIELFLIPNDFID GGIIGVSLILDHLFMSNPFLNFAFFVVILNIPFMIFGYKYIGKTFLVSTFIGIVGLAV IESSLHHVEAITTQPILATVFGGLLLGFGVGLVIRNGGSMDGTEILGILLTKKLPFSV GEFVMFINVFIFIWAVFVFGPEQAMYSFMTYYIAMKTIDAVIQGLDETKAVIIVSEQY DEISDAILHRLGRGTTKLKGKGGYTDEEKDVIYAVVTRLEVTKLKSIVFEVDQNAFIT IMNTHETRGGKFKNAIH*" /label="yqfU CDS" gene complement(2288209..2289090) /gene="yqfU" /locus_tag="BSU_25110" /old_locus_tag="BSU25110" /label="yqfU gene" promotor_-35 2289086..2289091 /Source="Nicolas_upshift_promotors" /id="U1953" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1102 /SigmaFactorBS="ctttcttatgttgttttgttgggGTCATAaaatctcctttcc tgCAATAACTATTTTAAATACattataaatctattttaccattaaacactgacacatt t" /listShort="yqfT, S944" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2289107..2289125 /Source="Nicolas_upshift_promotors" /id="U1953" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1102 /SigmaFactorBS="ctttcttatgttgttttgttgggGTCATAaaatctcctttcc tgCAATAACTATTTTAAATACattataaatctattttaccattaaacactgacacatt t" /listShort="yqfT, S944" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2289123 /Source="Nicolas_upshifts" /id="U1953" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1102 /SigmaFactorBS="ctttcttatgttgttttgttgggGTCATAaaatctcctttcc tgCAATAACTATTTTAAATACattataaatctattttaccattaaacactgacacatt t" /listShort="yqfT, S944" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(2289128..2289147) /Source="Nicolas_upshift_promotors" /id="U1954" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.706293706293706" /psig=1 /xcortree=2995 /SigmaFactorBS="cctccagacttaatgtatgggcaaatcagtaaaatgtgtcag tgtttAATGGTAAAATAGATTTATAatgtatttaaaatagttattgcaggaaaggaga t" /listShort="yqfU, S942, zur" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2289134) /Source="Nicolas_upshifts" /id="U1954" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.706293706293706" /psig=1 /xcortree=2995 /SigmaFactorBS="cctccagacttaatgtatgggcaaatcagtaaaatgtgtcag tgtttAATGGTAAAATAGATTTATAatgtatttaaaatagttattgcaggaaaggaga t" /listShort="yqfU, S942, zur" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2289136..2289463) /Source="Nicolas_S_feature" /locus_tag="new_2592930_2593257_c" /HighExp="Cold, T-4.40H, T-5.40H, Salt, GM-0.1, BMM, UNK1, MG 25, GM-0.2, SMM" /AntisenseName="yqfT" /AntisenseCor="-0.62379514374156597" /AntisenseRegPval="-29.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S943" promotor_-35 2289152..2289161 /Source="Nicolas_upshift_promotors" /id="U1955" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1273 /SigmaFactorBS="aataactattttaaatacattataaatctattttaccattaa acACTGACACATtttactgatttgCCCATACATTAAGTCTGGAGgtggaatgaccgat g" /listShort="yqfT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2289168 /Source="Nicolas_upshifts" /id="U1955" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1273 /SigmaFactorBS="aataactattttaaatacattataaatctattttaccattaa acACTGACACATtttactgatttgCCCATACATTAAGTCTGGAGgtggaatgaccgat g" /listShort="yqfT" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2289174..2289193 /Source="Nicolas_upshift_promotors" /id="U1955" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1273 /SigmaFactorBS="aataactattttaaatacattataaatctattttaccattaa acACTGACACATtttactgatttgCCCATACATTAAGTCTGGAGgtggaatgaccgat g" /listShort="yqfT" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2289206..2289460 /gene="yqfT" /locus_tag="BSU_25120" /old_locus_tag="BSU25120" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390391.1" /db_xref="EnsemblGenomes-Gn:BSU25120" /db_xref="EnsemblGenomes-Tr:CAB14442" /db_xref="InterPro:IPR020277" /db_xref="SubtiList:BG11666" /db_xref="UniProtKB/Swiss-Prot:P54477" /translation="MILFQRIILQRLNQATADDLLKYSKQYGISLTRSQAVEVANLLY GKNVNIFNESERMRLLKQVETITSKETAQTVNELFKQFTS*" /label="yqfT CDS" gene 2289206..2289460 /gene="yqfT" /locus_tag="BSU_25120" /old_locus_tag="BSU25120" /label="yqfT gene" downshifts 2289447 /Source="Nicolas_upshifts" /id="D1303" /incds=0 /nref=12 /ntot=72 /MaxReadThrough="3.97414" /MaxDrop="7.03976" /score="24.5413663" /energy="-9.8" /TU="U1953" /idTUdmin="U1955" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" CDS complement(2289487..2290380) /gene="nfo" /locus_tag="BSU_25130" /old_locus_tag="BSU25130" /EC_number="3.1.21.2" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12486072, 12949090, 16237020, 18203828, 19930460, 21441501, 24123749, 24244006, 24914186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12486072, 12949090, 16237020, 18203828, 19930460, 21441501, 24123749, 24244006, 24914186; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="type IV apurinic/apyrimidinic endonuclease" /protein_id="NP_390392.1" /db_xref="EnsemblGenomes-Gn:BSU25130" /db_xref="EnsemblGenomes-Tr:CAB14443" /db_xref="GOA:P54476" /db_xref="InterPro:IPR001719" /db_xref="InterPro:IPR013022" /db_xref="InterPro:IPR018246" /db_xref="InterPro:IPR036237" /db_xref="SubtiList:BG11665" /db_xref="UniProtKB/Swiss-Prot:P54476" /translation="MLRIGSHVSMSGKHMLLAASQEAVSYGANTFMIYTGAPQNTRRK KIEDLNIEAGRAHMQENGIDEIIVHAPYIINIGNTTNPSTFELGVDFLRSEIERTAAI GAKQIVLHPGAHVGAGAEAGIKKIIEGLNEVIDPNQNVQIALETMAGKGSECGRSFEE LAQIIEGVTHNEQLSVCFDTCHTHDAGYNIVEDFDGVLNEFDKIIGIDRIKVLHINDS KNVKGARKDRHENIGFGEIGFDALQYVVHHEQLKDIPKILETPYVGEDKKNKKPPYRF EIEMLKEKQFDDTLLEKILQQ*" /label="nfo CDS" gene complement(2289487..2290380) /gene="nfo" /locus_tag="BSU_25130" /old_locus_tag="BSU25130" /label="nfo gene" S_feature 2289492..2290293 /Source="Nicolas_S_feature" /locus_tag="new_2593286_2594087" /HighExp="S6, S7, C30, S8, S5, G135, C90, Gly, LoTm, Sw" /AntisenseName="nfo" /AntisenseCor="-0.36683479556464399" /AntisenseRegPval="-9.3000000000000007" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.948" /TUlongSig="NA" /TUlongPSig="NA" /label="S944" downshifts complement(2289508) /Source="Nicolas_upshifts" /id="D1304" /incds=0 /nref=46 /ntot=187 /MaxReadThrough="4.82641" /MaxDrop="6.05328" /score="16.7756411" /energy="-9.8" /TU="U1956" /idTUdmin="U1952" /TUdmin="-1870" /isTUend="FALSE" /label="downshifts" CDS complement(2290390..2291706) /gene="cshB" /locus_tag="BSU_25140" /old_locus_tag="BSU25140" /EC_number="3.6.1.-" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:16014871, 16352840, 18203828, 20572937, 23175651" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16014871, 16352840, 18203828, 20572937, 23175651; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent RNA helicase; cold shock" /protein_id="NP_390393.1" /db_xref="EnsemblGenomes-Gn:BSU25140" /db_xref="EnsemblGenomes-Tr:CAB14444" /db_xref="GOA:P54475" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR014014" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030881" /db_xref="SubtiList:BG11664" /db_xref="UniProtKB/Swiss-Prot:P54475" /translation="MKETKFELYELKPFIIDAVHRLGFYEPTDIQKRLIPAVLKKESV IGQSQTGTGKTHAYLLPLLNKIDPAKDVVQVVITAPTRELANQIYQEALKITQGEEGS QIRSKCFIGGTDKQKSIDKLKIQPHLVVGTPGRIADLIKEQALSVHKAESLVIDEADL MLDMGFLADVDYIGSRMPEDLQMLVFSATIPEKLKPFLKKYMENPKYAHVEPKQVTAA KIEHILIPSKHRDKDKLLFDIMSHLNPYLGIVFANTKNTADHIAQYLTGKGMKIGLLH GGLTPRERKKVMKQINDLEFTYIIATDLAARGIDIKGVSHVINYELPDDLDFYVHRVG RTARAGSSGQAMTIYELTDEDALVRLEKMGIEFEYLELEKGEWKKGDDRQRRKKRKKT PNEADEIAHRLVKKPKKVKPGYKKKMSYEMEKIKKKQRRNQSKKRK*" /label="cshB CDS" gene complement(2290390..2291706) /gene="cshB" /locus_tag="BSU_25140" /old_locus_tag="BSU25140" /label="cshB gene" promotor_-10 complement(2291742..2291761) /Source="Nicolas_upshift_promotors" /id="U1956" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.683316683316683" /psig=1 /xcortree=2492 /SigmaFactorBS="tacataactgaataaaacaaacgccttgcaaaCGTGGtgttt ttaagcaaaaTCGGGTATAATGTGATGATGgacacataatgtgccgctttaaggagct g" /listShort="cshB, nfo, S943, yqfU, S942, zur" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2291753) /Source="Nicolas_upshifts" /id="U1956" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.683316683316683" /psig=1 /xcortree=2492 /SigmaFactorBS="tacataactgaataaaacaaacgccttgcaaaCGTGGtgttt ttaagcaaaaTCGGGTATAATGTGATGATGgacacataatgtgccgctttaaggagct g" /listShort="cshB, nfo, S943, yqfU, S942, zur" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2291777..2291781) /Source="Nicolas_upshift_promotors" /id="U1956" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.683316683316683" /psig=1 /xcortree=2492 /SigmaFactorBS="tacataactgaataaaacaaacgccttgcaaaCGTGGtgttt ttaagcaaaaTCGGGTATAATGTGATGATGgacacataatgtgccgctttaaggagct g" /listShort="cshB, nfo, S943, yqfU, S942, zur" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2291810..2291819 /Source="Nicolas_upshift_promotors" /id="U1957" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1300 /SigmaFactorBS="aaaacaccacgtttgcaaggcgtttgttttattcagttaTGT AAAGCAAataccgcagcccaTGCATATTCTAATAGCAGAGagagctgaaaggaggtac a" /listShort="yqfQ, S945, ispH" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2291831 /Source="Nicolas_upshifts" /id="U1957" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1300 /SigmaFactorBS="aaaacaccacgtttgcaaggcgtttgttttattcagttaTGT AAAGCAAataccgcagcccaTGCATATTCTAATAGCAGAGagagctgaaaggaggtac a" /listShort="yqfQ, S945, ispH" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2291833..2291852 /Source="Nicolas_upshift_promotors" /id="U1957" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1300 /SigmaFactorBS="aaaacaccacgtttgcaaggcgtttgttttattcagttaTGT AAAGCAAataccgcagcccaTGCATATTCTAATAGCAGAGagagctgaaaggaggtac a" /listShort="yqfQ, S945, ispH" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2291875..2292618 /gene="yqfQ" /locus_tag="BSU_25150" /old_locus_tag="BSU25150" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390394.1" /db_xref="EnsemblGenomes-Gn:BSU25150" /db_xref="EnsemblGenomes-Tr:CAB14445" /db_xref="InterPro:IPR025571" /db_xref="SubtiList:BG11663" /db_xref="UniProtKB/Swiss-Prot:P54474" /translation="MFSPQQPMRNYPQPGPPRPMPNQRMMGRRPPNMRGPSFGAQQQG FQQAGQFLPQANAGARNGAGAGGGLKGMLSRFLPGGGGAGSAGVPGIPGAGAAASGGA GLQGIQNIANPASLSSMLGNVQKVLGMAQQVTPMIQQYGPLVRNLPAMMKLYSQLSKS DDTETEANEESEKQSVSEESSEKEKETETKTSDGNKKSKPKSSSLPKKSKTTDNKEQE LKTSAPKKKEAASPAPKRTSGSSKPRLYI*" /label="yqfQ CDS" gene 2291875..2292618 /gene="yqfQ" /locus_tag="BSU_25150" /old_locus_tag="BSU25150" /label="yqfQ gene" downshifts 2292600 /Source="Nicolas_upshifts" /id="D1305" /incds=0 /nref=1 /ntot=27 /MaxReadThrough="5.46594" /MaxDrop="3.2445" /score="4.32537428" /energy="-6.8" /TU="U1957" /idTUdmin="U1957" /TUdmin="-1056" /isTUend="FALSE" /label="downshifts" promotor_-35 2292622..2292629 /Source="Nicolas_upshift_promotors" /id="U1958" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig=1 /xcortree=2580 /SigmaFactorBS="atcaggcagttcaaaaccgagattatatatttaacatTCTTT GATatcttaagtgagaTTGGCTATAATGAGATCAGAagaatgcaagaatagagccgtt t" /listShort="S945, ispH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2292643..2292662 /Source="Nicolas_upshift_promotors" /id="U1958" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig=1 /xcortree=2580 /SigmaFactorBS="atcaggcagttcaaaaccgagattatatatttaacatTCTTT GATatcttaagtgagaTTGGCTATAATGAGATCAGAagaatgcaagaatagagccgtt t" /listShort="S945, ispH" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2292645..2292740 /Source="Nicolas_S_feature" /locus_tag="new_2596439_2596534" /HighExp="S8, S7, S6, Cold, H2O2, Salt, dia15, G180, Paraq, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S945" upshifts 2292645 /Source="Nicolas_upshifts" /id="U1958" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig=1 /xcortree=2580 /SigmaFactorBS="atcaggcagttcaaaaccgagattatatatttaacatTCTTT GATatcttaagtgagaTTGGCTATAATGAGATCAGAagaatgcaagaatagagccgtt t" /listShort="S945, ispH" /GFF_Attribute="listLong" /label="upshifts" CDS 2292741..2293685 /gene="ispH" /locus_tag="BSU_25160" /old_locus_tag="BSU25160" /EC_number="1.17.7.4" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 12706830, 15381396, 15469281, 17458547, 27169371; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductase" /protein_id="NP_390395.2" /db_xref="EnsemblGenomes-Gn:BSU25160" /db_xref="EnsemblGenomes-Tr:CAB14446" /db_xref="GOA:P54473" /db_xref="InterPro:IPR003451" /db_xref="SubtiList:BG11662" /db_xref="UniProtKB/Swiss-Prot:P54473" /translation="MDVIKISPRGYCYGVVDAMVIAKNASLDKSLPRPIYILGMIVHN KHVTDAFEEEGIFTLDGSNRLDILKQVDKGTVIFTAHGVSPEVRRIAEEKGLVAIDAT CPDVTKTHNLILEMKEKGYHVIYIGKKGHPEPEGAVGVAPEIVHLVETEEDVKNLDIQ SEKLIVTNQTTMSQWDVHDIMELVKEKYPHVEYHQEICLATQVRQEAVSEQAKKADLT IVVGDPKSNNSNRLAQVSEEIAGTKAYRIGDLSELKLEWLKGVNTVAVTAGASTPTPI TKEVIRFLEQFDHEDPSTWTTEHNIPLKKILPKVKAKN*" /label="ispH CDS" gene 2292741..2293685 /gene="ispH" /locus_tag="BSU_25160" /old_locus_tag="BSU25160" /label="ispH gene" downshifts 2293656 /Source="Nicolas_upshifts" /id="D1306" /incds=0 /nref=106 /ntot=243 /MaxReadThrough="4.04288" /MaxDrop="5.66904" /score="29.529951" /energy="-12.2" /TU="U1958" /idTUdmin="U1957" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2293708..2294829) /gene="yqfO" /locus_tag="BSU_25170" /old_locus_tag="BSU25170" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17187687, 17586767; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative GTP cyclohydrolase" /protein_id="NP_390396.1" /db_xref="EnsemblGenomes-Gn:BSU25170" /db_xref="EnsemblGenomes-Tr:CAB14447" /db_xref="GOA:P54472" /db_xref="InterPro:IPR002678" /db_xref="InterPro:IPR015867" /db_xref="InterPro:IPR017221" /db_xref="InterPro:IPR036069" /db_xref="SubtiList:BG11661" /db_xref="UniProtKB/Swiss-Prot:P54472" /translation="MAKSVNGQQIIQLFEQFSPKAYAVEGDKIGLQIGTLNKPIKNVM VTLDVLESVIDEAIEKEVDLIIAHHPPIFRSLKHISTDQPAGRLIEKCLKHDIAVYAA HTNLDVADGGVNDLLAEALELSETEVLAPTYTDPLKKLAVYVPKEYEEQVRAALGNAG AGHIGEYSHCAFSSEGIGSFKPLDGAKPFIGEVGELELVHEVRLETVFPKSVEKAVIN AMIKSHPYEEVAYDIYPVEQTPAEKGLGRVGTLKNEMTLKEFALFVKDKLDVNGVRMV GDADSMVKKVAVLGGDGNKYIHHAKRKGADVYVTGDLYFHVAHDAMMLGLNVVDPGHY AEKIMKEGVTRKLTSMCNDKKFGVNIFVSETDTNPFTFL*" /label="yqfO CDS" gene complement(2293708..2294829) /gene="yqfO" /locus_tag="BSU_25170" /old_locus_tag="BSU25170" /label="yqfO gene" downshifts complement(2293733) /Source="Nicolas_upshifts" /id="D1307" /incds=0 /nref=63 /ntot=224 /MaxReadThrough="3.241" /MaxDrop="4.76436" /score="27.9821938" /energy="-12.2" /TU="NA" /idTUdmin="U1959" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2294822..2295472) /gene="trmK" /locus_tag="BSU_25180" /old_locus_tag="BSU25180" /EC_number="2.1.1.217" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:18420655, 27098549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18420655, 27098549; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA (adenine(22)-N(1))-methyltransferase" /protein_id="NP_390397.1" /db_xref="EnsemblGenomes-Gn:BSU25180" /db_xref="EnsemblGenomes-Tr:CAB14448" /db_xref="GOA:P54471" /db_xref="InterPro:IPR006901" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11660" /db_xref="UniProtKB/Swiss-Prot:P54471" /translation="MADIGSDHAYLPCYAVLNHKASGAIAGEITDGPFLSAKRQVEKS GLNSHISVRQGDGLEVIKKGEADAITIAGMGGALIAHILEAGKDKLTGKERLILQPNI HAVHIREWLYKERYALIDEVILEEDGKCYEVLVAEAGDRDAAYDGISLSAGMLVGPFL AKEKNAVFLKKWTQELQHTQSIYEQISQAADTEQNKQKLKELADRMELLKEVIDHG*" /label="trmK CDS" gene complement(2294822..2295472) /gene="trmK" /locus_tag="BSU_25180" /old_locus_tag="BSU25180" /label="trmK gene" S_feature complement(2295473..2295581) /Source="Nicolas_S_feature" /locus_tag="new_2599267_2599375_c" /HighExp="LBGexp, LBGtran, dia15, dia0, Lbexp, G150, G180, LBGstat, Oxctl, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 0.98, 0.998" /TUlongSig="SigH, SigEF, SigA, SigA, SigA, SigA, SigA" /TUlongPSig="1, 0.974, 0.979, 1, 1, 0.999, 0.998" /label="S946" promotor_-10 complement(2295569..2295588) /Source="Nicolas_upshift_promotors" /id="U1959" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig=1 /xcortree=2573 /SigmaFactorBS="tcaaaagaaataatttcaaaatcatttgcttcaGCTTGgatt ccgggctgattTTTTATATGATAGTAAAGGAaaaaatgattgagaaaagttgtgatga c" /listShort="S946, trmK, yqfO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2295581) /Source="Nicolas_upshifts" /id="U1959" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig=1 /xcortree=2573 /SigmaFactorBS="tcaaaagaaataatttcaaaatcatttgcttcaGCTTGgatt ccgggctgattTTTTATATGATAGTAAAGGAaaaaatgattgagaaaagttgtgatga c" /listShort="S946, trmK, yqfO" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2295583..2295696) /Source="Nicolas_S_feature" /locus_tag="new_2599377_2599490_c" /HighExp="Lbstat, M0t90, M9-stat, S2, T1.0H, T1.30H, T2.30H, T3.0H, S7, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.98, 0.998" /TUlongSig="SigH, SigEF, SigA, SigA, SigA, SigA, SigA" /TUlongPSig="1, 0.974, 0.979, 1, 1, 0.999, 0.998" /label="S947" promotor_-35 complement(2295604..2295608) /Source="Nicolas_upshift_promotors" /id="U1959" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig=1 /xcortree=2573 /SigmaFactorBS="tcaaaagaaataatttcaaaatcatttgcttcaGCTTGgatt ccgggctgattTTTTATATGATAGTAAAGGAaaaaatgattgagaaaagttgtgatga c" /listShort="S946, trmK, yqfO" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2295729..2296091) /gene="cccA" /locus_tag="BSU_25190" /old_locus_tag="BSU25190" /function="16.7: Manage energy" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10024472, 10473570, 11361075, 15995641, 19222757" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10024472, 10473570, 11361075, 15995641, 19222757; Product type c: carrier" /codon_start=1 /transl_table=11 /product="cytochrome c550" /protein_id="NP_390398.1" /db_xref="EnsemblGenomes-Gn:BSU25190" /db_xref="EnsemblGenomes-Tr:CAB14449" /db_xref="GOA:P24469" /db_xref="InterPro:IPR009056" /db_xref="InterPro:IPR012218" /db_xref="InterPro:IPR036909" /db_xref="SubtiList:BG10315" /db_xref="UniProtKB/Swiss-Prot:P24469" /translation="MKWNPLIPFLLIAVLGIGLTFFLSVKGLDDSREIASGGESKSAE KKDANASPEEIYKANCIACHGENYEGVSGPSLKGVGDKKDVAEIKTKIEKGGNGMPSG LVPADKLDDMAEWVSKIK*" /label="cccA CDS" gene complement(2295729..2296091) /gene="cccA" /locus_tag="BSU_25190" /old_locus_tag="BSU25190" /label="cccA gene" downshifts complement(2295741) /Source="Nicolas_upshifts" /id="D1308" /incds=0 /nref=3 /ntot=88 /MaxReadThrough="4.32389" /MaxDrop="3.4795" /score="-4.13120914" /energy="-7.6" /TU="U1961,U1962" /idTUdmin="U1968" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" promotor_-35 2296087..2296091 /Source="Nicolas_upshift_promotors" /id="U1960" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=693 /SigmaFactorBS="agcaaaaatggaataagcgggttccatTTCATttcccttCCC CCTTTTTGATCCttccccctatgtaaacacttctaattctaacttatttttacaaaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2296099..2296113 /Source="Nicolas_upshift_promotors" /id="U1960" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=693 /SigmaFactorBS="agcaaaaatggaataagcgggttccatTTCATttcccttCCC CCTTTTTGATCCttccccctatgtaaacacttctaattctaacttatttttacaaaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2296120 /Source="Nicolas_upshifts" /id="U1960" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=693 /SigmaFactorBS="agcaaaaatggaataagcgggttccatTTCATttcccttCCC CCTTTTTGATCCttccccctatgtaaacacttctaattctaacttatttttacaaaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2296128..2296147) /Source="Nicolas_upshift_promotors" /id="U1961" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.274725274725275" /psig="0.98001998001998" /xcortree=484 /SigmaFactorBS="ataaaaaacttttgtatagcaatcCATTTACTttttgtaaaa aTAAGTTAGAATTAGAAGTGTttacatagggggaaggatcaaaaagggggaagggaaa t" /listShort="cccA, S947, S946, trmK, yqfO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2296130) /Source="Nicolas_upshifts" /id="U1961" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.274725274725275" /psig="0.98001998001998" /xcortree=484 /SigmaFactorBS="ataaaaaacttttgtatagcaatcCATTTACTttttgtaaaa aTAAGTTAGAATTAGAAGTGTttacatagggggaaggatcaaaaagggggaagggaaa t" /listShort="cccA, S947, S946, trmK, yqfO" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2296132..2296253) /Source="Nicolas_S_feature" /locus_tag="new_2599926_2600047_c" /HighExp="Lbstat, T3.0H, T1.30H, M9-stat, T2.30H, T1.0H, T2.0H, T3.30H, M0t90, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH, SigEF, SigA, SigA, SigA, SigA" /TUshortPSig="0.998, 1, 0.974, 0.979, 1, 1, 0.999" /TUlongSig="SigA, SigGF" /TUlongPSig="0.998, 0.979" /label="S948" promotor_-35 complement(2296159..2296166) /Source="Nicolas_upshift_promotors" /id="U1961" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.274725274725275" /psig="0.98001998001998" /xcortree=484 /SigmaFactorBS="ataaaaaacttttgtatagcaatcCATTTACTttttgtaaaa aTAAGTTAGAATTAGAAGTGTttacatagggggaaggatcaaaaagggggaagggaaa t" /listShort="cccA, S947, S946, trmK, yqfO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2296242..2296261) /Source="Nicolas_upshift_promotors" /id="U1962" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.42957042957043" /psig="0.998001998001998" /xcortree=363 /SigmaFactorBS="tgaaaaatttcaaaatctaattccatattttcTATTGTAagc gtatacaataCATTATACAATAGAATAAAAaggatattagagatttaggcatgtttct a" /listShort="S948, cccA, S947, S946, trmK, yqfO" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 2296250..2296269 /Source="Nicolas_upshift_promotors" /id="U1963" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.485514485514486" /psig="0.997002997002997" /xcortree=360 /SigmaFactorBS="ctttatacaaaattgaatagaaacatgcctaaatctcTaata tcctttttattcTATTGTATAATGTATTGTATacgcttacaatagaaaatatggaatt a" /listShort="S950, S951" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2296253) /Source="Nicolas_upshifts" /id="U1962" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.42957042957043" /psig="0.998001998001998" /xcortree=363 /SigmaFactorBS="tgaaaaatttcaaaatctaattccatattttcTATTGTAagc gtatacaataCATTATACAATAGAATAAAAaggatattagagatttaggcatgtttct a" /listShort="S948, cccA, S947, S946, trmK, yqfO" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2296255..2296394) /Source="Nicolas_S_feature" /locus_tag="new_2600049_2600188_c" /HighExp="Lbstat, S8, S1, S7, G/S, BT, Mal, Gly, S6, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH, SigEF, SigA, SigA, SigA, SigA" /TUshortPSig="1, 0.974, 0.979, 1, 1, 0.999" /TUlongSig="SigA, SigGF" /TUlongPSig="0.998, 0.979" /label="S949" S_feature 2296256..2296360 /Source="Nicolas_S_feature" /locus_tag="new_2600050_2600154" /HighExp="T2.30H, M9-stat, T3.0H, T1.30H, T2.0H, T1.0H, T3.30H, T4.0H, M0t90, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S950" upshifts 2296256 /Source="Nicolas_upshifts" /id="U1963" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.485514485514486" /psig="0.997002997002997" /xcortree=360 /SigmaFactorBS="ctttatacaaaattgaatagaaacatgcctaaatctcTaata tcctttttattcTATTGTATAATGTATTGTATacgcttacaatagaaaatatggaatt a" /listShort="S950, S951" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2296275..2296281) /Source="Nicolas_upshift_promotors" /id="U1962" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.42957042957043" /psig="0.998001998001998" /xcortree=363 /SigmaFactorBS="tgaaaaatttcaaaatctaattccatattttcTATTGTAagc gtatacaataCATTATACAATAGAATAAAAaggatattagagatttaggcatgtttct a" /listShort="S948, cccA, S947, S946, trmK, yqfO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2296324..2296331 /Source="Nicolas_upshift_promotors" /id="U1964" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=558 /SigmaFactorBS="tgaaatttttcaccacaatgttCATTTGCAaatgacatcatt tTTCAGTAAAATAAAGGCATAttatccatatatctttttaaaaaaagaagaacggatc t" /listShort="S951" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2296345..2296364 /Source="Nicolas_upshift_promotors" /id="U1964" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=558 /SigmaFactorBS="tgaaatttttcaccacaatgttCATTTGCAaatgacatcatt tTTCAGTAAAATAAAGGCATAttatccatatatctttttaaaaaaagaagaacggatc t" /listShort="S951" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2296362..2298511 /Source="Nicolas_S_feature" /locus_tag="new_2600156_2602305" /HighExp="S2, T4.0H, T5.0H, Lbstat, M9-stat, T3.30H, S8, T3.0H, C30, T2.0H" /AntisenseName="sigA" /AntisenseCor="-0.16938350693676901" /AntisenseRegPval="-2.2999999999999998" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S951" upshifts 2296362 /Source="Nicolas_upshifts" /id="U1964" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=558 /SigmaFactorBS="tgaaatttttcaccacaatgttCATTTGCAaatgacatcatt tTTCAGTAAAATAAAGGCATAttatccatatatctttttaaaaaaagaagaacggatc t" /listShort="S951" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2296420..2297535) /gene="sigA" /locus_tag="BSU_25200" /old_locus_tag="BSU25200" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12455702, 12682299, 14527287, 15060039, 15670950, 28648455" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12455702, 12682299, 14527287, 15060039, 15670950, 28648455; Product type f : factor" /codon_start=1 /transl_table=11 /product="RNA polymerase major sigma-43 factor (sigma-A)" /protein_id="NP_390399.2" /db_xref="EnsemblGenomes-Gn:BSU25200" /db_xref="EnsemblGenomes-Tr:CAB14450" /db_xref="GOA:P06224" /db_xref="InterPro:IPR000943" /db_xref="InterPro:IPR007127" /db_xref="InterPro:IPR007624" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR007630" /db_xref="InterPro:IPR009042" /db_xref="InterPro:IPR012760" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR028630" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10314" /db_xref="UniProtKB/Swiss-Prot:P06224" /translation="MADKQTHETELTFDQVKEQLTESGKKRGVLTYEEIAERMSSFEI ESDQMDEYYEFLGEQGVELISENEETEDPNIQQLAKAEEEFDLNDLSVPPGVKINDPV RMYLKEIGRVNLLSAKEEIAYAQKIEEGDEESKRRLAEANLRLVVSIAKRYVGRGMLF LDLIQEGNMGLMKAVEKFDYRKGYKFSTYATWWIRQAITRAIADQARTIRIPVHMVET INKLIRVQRQLLQDLGREPTPEEIAEDMDLTPEKVREILKIAQEPVSLETPIGEEDDS HLGDFIEDQEATSPSDHAAYELLKEQLEDVLDTLTDREENVLRLRFGLDDGRTRTLEE VGKVFGVTRERIRQIEAKALRKLRHPSRSKRLKDFLE*" /label="sigA CDS" gene complement(2296420..2297535) /gene="sigA" /locus_tag="BSU_25200" /old_locus_tag="BSU25200" /label="sigA gene" downshifts complement(2296439) /Source="Nicolas_upshifts" /id="D1309" /incds=0 /nref=118 /ntot=198 /MaxReadThrough="4.93947" /MaxDrop="6.16048" /score="4.75833607" /energy="-11.7" /TU="U1966,U1968,U1969,U1970,U1972,U1973" /idTUdmin="U1970" /TUdmin="-287" /isTUend="FALSE" /label="downshifts" S_feature complement(2297536..2297733) /Source="Nicolas_S_feature" /locus_tag="new_2601330_2601527_c" /HighExp="BC, Cold, SMMPr, S1, BI, G135, C30, Lbstat, S5, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH, SigEF, SigA, SigA, SigA, SigA" /TUshortPSig="1, 0.974, 0.979, 1, 1, 0.999" /TUlongSig="SigA, SigGF" /TUlongPSig="0.998, 0.979" /label="S952" CDS complement(2297734..2299545) /gene="dnaG" /locus_tag="BSU_25210" /old_locus_tag="BSU25210" /EC_number="2.7.7.-" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 3100394, 9387153, 12682299, 16036556, 28386108; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA primase" /protein_id="NP_390400.2" /db_xref="EnsemblGenomes-Gn:BSU25210" /db_xref="EnsemblGenomes-Tr:CAB14451" /db_xref="GOA:P05096" /db_xref="InterPro:IPR002694" /db_xref="InterPro:IPR006171" /db_xref="InterPro:IPR006295" /db_xref="InterPro:IPR013264" /db_xref="InterPro:IPR016136" /db_xref="InterPro:IPR019475" /db_xref="InterPro:IPR030846" /db_xref="InterPro:IPR034151" /db_xref="InterPro:IPR036185" /db_xref="InterPro:IPR036977" /db_xref="InterPro:IPR037068" /db_xref="PDB:5GUJ" /db_xref="SubtiList:BG10313" /db_xref="UniProtKB/Swiss-Prot:P05096" /translation="MGNRIPDEIVDQVQKSADIVEVIGDYVQLKKQGRNYFGLCPFHG ESTPSFSVSPDKQIFHCFGCGAGGNVFSFLRQMEGYSFAESVSHLADKYQIDFPDDIT VHSGARPESSGEQKMAEAHELLKKFYHHLLINTKEGQEALDYLLSRGFTKELINEFQI GYALDSWDFITKFLVKRGFSEAQMEKAGLLIRREDGSGYFDRFRNRVMFPIHDHHGAV VAFSGRALGSQQPKYMNSPETPLFHKSKLLYNFYKARLHIRKQERAVLFEGFADVISA VSSDVKESIATMGTSLTDDHVKILRRNVEEIILCYDSDKAGYEATLKASELLQKKGCK VRVAMIPDGLDPDDYIKKFGGEKFKNDIIDASVTVMAFKMQYFRKGKNLSDEGDRLAY IKDVLKEISTLSGSLEQEVYVKQLASEFSLSQESLTEQLSVFSKQNKPADNSGETKTR RAHLTTKARQKRLRPAYENAERLLLAHMLRDRSVIKKVIDRVGFQFNIDEHRALAAYL YAFYEEGAELTPQHLMARVTDDHISQLLSDILMLQVNQELSEAELSDYVKKVLNQRNW SMIKEKEAERAEAERQKDFLRAASLAQEIVTLNRSLK*" /label="dnaG CDS" gene complement(2297734..2299545) /gene="dnaG" /locus_tag="BSU_25210" /old_locus_tag="BSU25210" /label="dnaG gene" promotor_-35 2299140..2299146 /Source="Nicolas_upshift_promotors" /id="U1965" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.738261738261738" /psig="0.998001998001998" /xcortree=455 /SigmaFactorBS="aaagcccctagaaagcagataatccagtgcctcttgaccttc ttTTGTATTtattaacaaatGATGGTAAAATTTCTTCAGGagctcatgtgcctcagcc a" /listShort="antE" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2299156 /Source="Nicolas_upshifts" /id="U1965" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.738261738261738" /psig="0.998001998001998" /xcortree=455 /SigmaFactorBS="aaagcccctagaaagcagataatccagtgcctcttgaccttc ttTTGTATTtattaacaaatGATGGTAAAATTTCTTCAGGagctcatgtgcctcagcc a" /listShort="antE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2299158..2299177 /Source="Nicolas_upshift_promotors" /id="U1965" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.738261738261738" /psig="0.998001998001998" /xcortree=455 /SigmaFactorBS="aaagcccctagaaagcagataatccagtgcctcttgaccttc ttTTGTATTtattaacaaatGATGGTAAAATTTCTTCAGGagctcatgtgcctcagcc a" /listShort="antE" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2299185..2299481 /gene="antE" /locus_tag="BSU_25220" /old_locus_tag="BSU25220" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId: 9864351" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_054587.1" /db_xref="EnsemblGenomes-Gn:BSU25220" /db_xref="EnsemblGenomes-Tr:CAE01462" /db_xref="GOA:Q7WY63" /db_xref="SubtiList:BG14178" /db_xref="UniProtKB/Swiss-Prot:Q7WY63" /translation="MPQPFFVLQKTLAGLRNGLLYHLENQFGICQQGEKPTRQKNSLP SALKKRKHCRPLRSQSNEKSVCRAIRKTKVCFLHEKDRVQSSFGLASLIEHNHL*" /label="antE CDS" gene 2299185..2299481 /gene="antE" /locus_tag="BSU_25220" /old_locus_tag="BSU25220" /label="antE gene" CDS complement(2299579..2300073) /gene="yqxD" /locus_tag="BSU_25230" /old_locus_tag="BSU25230" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 9387153, 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390401.2" /db_xref="EnsemblGenomes-Gn:BSU25230" /db_xref="EnsemblGenomes-Tr:CAB14452" /db_xref="InterPro:IPR003791" /db_xref="SubtiList:BG10312" /db_xref="UniProtKB/Swiss-Prot:P17868" /translation="MEGWRITLLNEQEKTIFVDADACPVKDEILQTASEYEVQVLFVA SFEHYQLSRSNEEKWKYVDPHKEAADLYIANHVKPGDIVVTQDIGLASLLLNRNVSVM SERGRLYKEDTIDFALEGRHFSGKQRRKGVYAKGPKKLNKEDRERFITLLQKILSNDE GILH*" /label="yqxD CDS" gene complement(2299579..2300073) /gene="yqxD" /locus_tag="BSU_25230" /old_locus_tag="BSU25230" /label="yqxD gene" promotor_-10 complement(2300046..2300064) /Source="Nicolas_upshift_promotors" /id="U1966" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=431 /SigmaFactorBS="taataaaggatgtgcgattttgcttgcttttatGCAGGAGTT taatggagggaTGGAGAATTACTCTTCTTAatgaacaagaaaagacgatttttgtcga t" /listShort="yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="promotor_-10" upshifts complement(2300057) /Source="Nicolas_upshifts" /id="U1966" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=431 /SigmaFactorBS="taataaaggatgtgcgattttgcttgcttttatGCAGGAGTT taatggagggaTGGAGAATTACTCTTCTTAatgaacaagaaaagacgatttttgtcga t" /listShort="yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="upshifts" S_feature complement(2300074..2300187) /Source="Nicolas_S_feature" /locus_tag="new_2603868_2603981_c" /HighExp="S5, S4, S6, S7, S8, S3, Etha, dia15, G180, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA, SigA, SigA, SigA" /TUshortPSig="0.974, 0.979, 1, 1, 0.999" /TUlongSig="SigA, SigGF" /TUlongPSig="0.998, 0.979" /label="S953" promotor_-35 complement(2300076..2300084) /Source="Nicolas_upshift_promotors" /id="U1966" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=431 /SigmaFactorBS="taataaaggatgtgcgattttgcttgcttttatGCAGGAGTT taatggagggaTGGAGAATTACTCTTCTTAatgaacaagaaaagacgatttttgtcga t" /listShort="yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="promotor_-35" promotor_-35 2300082..2300087 /Source="Nicolas_upshift_promotors" /id="U1967" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.832167832167832" /psig="0.832167832167832" /xcortree=1219 /SigmaFactorBS="ttctccatccctccattaaactccTGCATAaaagcaagcaaa atcGCACATCCTTTATTATTGTggatgtatatgaatttgtcgaaaaatttccgggaga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2300103..2300121 /Source="Nicolas_upshift_promotors" /id="U1967" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.832167832167832" /psig="0.832167832167832" /xcortree=1219 /SigmaFactorBS="ttctccatccctccattaaactccTGCATAaaagcaagcaaa atcGCACATCCTTTATTATTGTggatgtatatgaatttgtcgaaaaatttccgggaga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2300118 /Source="Nicolas_upshifts" /id="U1967" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.832167832167832" /psig="0.832167832167832" /xcortree=1219 /SigmaFactorBS="ttctccatccctccattaaactccTGCATAaaagcaagcaaa atcGCACATCCTTTATTATTGTggatgtatatgaatttgtcgaaaaatttccgggaga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2300172..2300190) /Source="Nicolas_upshift_promotors" /id="U1968" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=794 /SigmaFactorBS="ttataataaaaaattgtgataaaatgattaattttaGGTTTA aggatcgtgtgatacGAATAAACTATTATGGGTAagatgtcaagaatttctcccggaa a" /listShort="S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="promotor_-10" upshifts complement(2300187) /Source="Nicolas_upshifts" /id="U1968" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=794 /SigmaFactorBS="ttataataaaaaattgtgataaaatgattaattttaGGTTTA aggatcgtgtgatacGAATAAACTATTATGGGTAagatgtcaagaatttctcccggaa a" /listShort="S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="upshifts" S_feature complement(2300189..2300266) /Source="Nicolas_S_feature" /locus_tag="new_2603983_2604060_c" /HighExp="Etha, G180, G135, G150, LBGtran, LBGexp, dia15, H2O2, Oxctl, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="0.979, 1, 1, 0.999" /TUlongSig="SigA, SigGF" /TUlongPSig="0.998, 0.979" /label="S954" promotor_-35 complement(2300206..2300211) /Source="Nicolas_upshift_promotors" /id="U1968" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=794 /SigmaFactorBS="ttataataaaaaattgtgataaaatgattaattttaGGTTTA aggatcgtgtgatacGAATAAACTATTATGGGTAagatgtcaagaatttctcccggaa a" /listShort="S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="promotor_-35" promotor_-10 complement(2300232..2300251) /Source="Nicolas_upshift_promotors" /id="U1969" /multdbtbs="SigA,SigA" /comp="M16" /sig="SigA" /pcomp="0.731268731268731" /psig="0.97902097902098" /xcortree=2530 /SigmaFactorBS="ctcaggacgctctatcctgggtttttggctgtgccaaaaggg aataatgaaaaacaATAGcatctttgtgaagttTGTATTATAATAAAAAATTGtgata a" /listShort="S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="promotor_-10" upshifts complement(2300266) /Source="Nicolas_upshifts" /id="U1969" /multdbtbs="SigA,SigA" /comp="M16" /sig="SigA" /pcomp="0.731268731268731" /psig="0.97902097902098" /xcortree=2530 /SigmaFactorBS="ctcaggacgctctatcctgggtttttggctgtgccaaaaggg aataatgaaaaacaATAGcatctttgtgaagttTGTATTATAATAAAAAATTGtgata a" /listShort="S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="upshifts" promotor_-35 complement(2300267..2300270) /Source="Nicolas_upshift_promotors" /id="U1969" /multdbtbs="SigA,SigA" /comp="M16" /sig="SigA" /pcomp="0.731268731268731" /psig="0.97902097902098" /xcortree=2530 /SigmaFactorBS="ctcaggacgctctatcctgggtttttggctgtgccaaaaggg aataatgaaaaacaATAGcatctttgtgaagttTGTATTATAATAAAAAATTGtgata a" /listShort="S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="promotor_-35" CDS complement(2300327..2301139) /gene="ppsR" /locus_tag="BSU_25240" /old_locus_tag="BSU25240" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15720552, 20044937" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15720552, 20044937; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional ADP-dependent kinase-Pi-dependent pyrophosphorylase / positive regulator of gluconeogenesis" /protein_id="NP_390402.1" /db_xref="EnsemblGenomes-Gn:BSU25240" /db_xref="EnsemblGenomes-Tr:CAB14453" /db_xref="GOA:P54470" /db_xref="InterPro:IPR005177" /db_xref="InterPro:IPR026565" /db_xref="SubtiList:BG11659" /db_xref="UniProtKB/Swiss-Prot:P54470" /translation="MNNRIIYVVSDSVGETAELVVKAALSQFNGSADDTHVRRIPYVE DIGTINEVISLAKADGGIICFTLVVPEIREYLIAEAEKANVLYYDIIGPLIDKMETAY GLTAKYEPGRVRQLDEDYFKKVEAIEFAVKYDDGRDPRGILKADIVLIGVSRTSKTPL SQYLAHKRLKVANVPIVPEVDPPEELFNVDPKKCIGLKISPDKLNHIRKERLKSLGLN DKAIYANINRIKEELEYFEKIVDRIGCQVVDVSNKAVEETANIIHHLKTKNI*" /label="ppsR CDS" gene complement(2300327..2301139) /gene="ppsR" /locus_tag="BSU_25240" /old_locus_tag="BSU25240" /label="ppsR gene" CDS complement(2301165..2301803) /gene="ccpN" /locus_tag="BSU_25250" /old_locus_tag="BSU25250" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15720552, 17011578, 17962296, 18511073, 18586936, 19202299, 19726675, 28178965" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15720552, 17011578, 17962296, 18511073, 18586936, 19202299, 19726675, 28178965; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative regulator of gluconeogenesis" /protein_id="NP_390403.1" /db_xref="EnsemblGenomes-Gn:BSU25250" /db_xref="EnsemblGenomes-Tr:CAB14454" /db_xref="GOA:O34994" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR013196" /db_xref="InterPro:IPR016842" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:3FV6" /db_xref="PDB:3FWR" /db_xref="PDB:3FWS" /db_xref="SubtiList:BG13768" /db_xref="UniProtKB/Swiss-Prot:O34994" /translation="MSTIELNKRQEHILQIVKENGPITGEHIAEKLNLTRATLRPDLA ILTMSGFLEARPRVGYFYTGKTGTQLLADKLKKLQVKDFQSIPVVIHENVSVYDAICT MFLEDVGTLFVVDRDAVLVGVLSRKDLLRASIGQQELTSVPVHIIMTRMPNITVCRRE DYVMDIAKHLIEKQIDALPVIKDTDKGFEVIGRVTKTNMTKILVSLSENEIL*" /label="ccpN CDS" gene complement(2301165..2301803) /gene="ccpN" /locus_tag="BSU_25250" /old_locus_tag="BSU25250" /label="ccpN gene" S_feature complement(2301804..2301935) /Source="Nicolas_S_feature" /locus_tag="new_2605598_2605729_c" /HighExp="G135, dia5, G180, G150, dia15, H2O2, LBGexp, Lbexp, Oxctl, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="1, 1, 0.999, 0.998" /TUlongSig="SigGF" /TUlongPSig="0.979" /label="S955" promotor_-10 complement(2301929..2301948) /Source="Nicolas_upshift_promotors" /id="U1970" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2057 /SigmaFactorBS="atggtaagcttggcggatgagatcaagtCCTTTGCGaatatg aatgccctTATTGTAAAATAAAGAGAGAaaaggcggttgctgtgtgatcggtaatcgt c" /listShort="S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948" /listLong="cccA, S947, S946, trmK, yqfO" /label="promotor_-10" CDS complement(2301936..2303975) /gene="glyS" /locus_tag="BSU_25260" /old_locus_tag="BSU25260" /EC_number="6.1.1.14" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 15890195; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycyl-tRNA synthetase (beta subunit)" /protein_id="NP_390404.2" /db_xref="EnsemblGenomes-Gn:BSU25260" /db_xref="EnsemblGenomes-Tr:CAB14455" /db_xref="GOA:P54381" /db_xref="InterPro:IPR006194" /db_xref="InterPro:IPR009080" /db_xref="InterPro:IPR015944" /db_xref="SubtiList:BG11658" /db_xref="UniProtKB/Swiss-Prot:P54381" /translation="MSKQDLLLEIGLEEMPARFLNESMVQLGDKLTGWLKEKNITHGE VKLFNTPRRLAVFVKDVAEKQDDIKEEAKGPAKKIALDADGNWTKAAIGFSKGQGANV EDLYIKEVKGIEYVFVQKFQAGQETKSLLPELSGLITSLHFPKNMRWGNEDLRYIRPI KWIVALFGQDVIPFSITNVESGRTTQGHRFLGHEVSIESPSAYEEQLKGQHVIADPSV RKQMIQSQLETMAAENNWSIPVDEDLLDEVNHLVEYPTALYGSFESEFLSIPEEVLVT TMKEHQRYFPVKDKNGDLLPHFITVRNGNSHAIENVARGNEKVLRARLSDASFFYKED QKLNIDANVKKLENIVFHEELGSLADKVRRVTSIAEKLAVRLQADEDTLKHVKRAAEI SKFDLVTHMIYEFPELQGIMGEKYARMLGEDEAVAAAVNEHYMPRSAGGETPSTFTGA VVAMADKLDTIASFFSIGVIPTGSQDPYGLRRQASGIVAILLDRNWGISFEELLTFVQ TDKENELLDFFTQRLKYVLNAEQIRHDVIDAVLESSELEPYSALHKAQVLEQKLGAPG FKETAEALGRVISISKKGVRGDIQPDLFENEYEAKLFDAYQTAKQNLQENFSKKDYEA ALASLAALKEPIDAYFDHTMVIADNESLKANRLAQMVSLADEIKSFANMNALIVK*" /label="glyS CDS" gene complement(2301936..2303975) /gene="glyS" /locus_tag="BSU_25260" /old_locus_tag="BSU25260" /label="glyS gene" upshifts complement(2301938) /Source="Nicolas_upshifts" /id="U1970" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2057 /SigmaFactorBS="atggtaagcttggcggatgagatcaagtCCTTTGCGaatatg aatgccctTATTGTAAAATAAAGAGAGAaaaggcggttgctgtgtgatcggtaatcgt c" /listShort="S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948" /listLong="cccA, S947, S946, trmK, yqfO" /label="upshifts" promotor_-35 complement(2301963..2301970) /Source="Nicolas_upshift_promotors" /id="U1970" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2057 /SigmaFactorBS="atggtaagcttggcggatgagatcaagtCCTTTGCGaatatg aatgccctTATTGTAAAATAAAGAGAGAaaaggcggttgctgtgtgatcggtaatcgt c" /listShort="S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948" /listLong="cccA, S947, S946, trmK, yqfO" /label="promotor_-35" downshifts complement(2301982) /Source="Nicolas_upshifts" /id="D1310" /incds=0 /nref=1 /ntot=2 /MaxReadThrough="6.14024" /MaxDrop="3.62589" /score="-9.01330408" /energy="-8.2" /TU="U1972,U1973,U1975" /idTUdmin="U1975" /TUdmin="-1320" /isTUend="FALSE" /label="downshifts" downshifts complement(2302048) /Source="Nicolas_upshifts" /id="D1311" /incds=1 /nref=10 /ntot=162 /MaxReadThrough="6.17154" /MaxDrop="3.30313" /score="-9.01330408" /energy="-8.2" /TU="U1972,U1973,U1975" /idTUdmin="U1975" /TUdmin="-1386" /isTUend="FALSE" /label="downshifts" CDS complement(2303968..2304855) /gene="glyQ" /locus_tag="BSU_25270" /old_locus_tag="BSU25270" /EC_number="6.1.1.14" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 15890195; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycyl-tRNA synthetase (alpha subunit)" /protein_id="NP_390405.1" /db_xref="EnsemblGenomes-Gn:BSU25270" /db_xref="EnsemblGenomes-Tr:CAB14456" /db_xref="GOA:P54380" /db_xref="InterPro:IPR002310" /db_xref="InterPro:IPR006194" /db_xref="SubtiList:BG11657" /db_xref="UniProtKB/Swiss-Prot:P54380" /translation="MNIQDMILTLQKHWSSQGCVLMQAYDVEKGAGTMSPYTFLRSIG PEPWKVAYVEPSRRPADGRYGENPNRLYQHHQFQVIIKPSPDNIQELYLDSLRALGID PLEHDIRFVEDNWENPSLGCAGLGWEVWLDGMEITQFTYFQQVGGLECKPVSVEITYG IERLASYIQDKENVFDLEWTSGFTVKDLFMMAEYEHSVYTFETSDVDMLFQLFSTYEK EAIKQMDNGLVHPAYDYVLKCSHTFNLLDAKGAISVTERTGYIARVRNLARKVAKTYY EEREKLGFPMLKGEGSSHE*" /label="glyQ CDS" gene complement(2303968..2304855) /gene="glyQ" /locus_tag="BSU_25270" /old_locus_tag="BSU25270" /label="glyQ gene" misc_RNA complement(2304938..2305112) /gene="tboG" /locus_tag="BSU_misc_RNA_39" /product="T-box riboswitch controlling synthesis of glycine-tRNA ligase" /experiment="publication(s) with functional evidences, PMID:1317842, 9098041, 12165569, 12547201, 15890195, 26229106" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1317842, 9098041, 12165569, 12547201, 15890195, 26229106; Product type n : RNA" /label="tboG RNA" gene complement(2304938..2305112) /gene="tboG" /locus_tag="BSU_misc_RNA_39" /label="tboG gene" downshifts complement(2304972) /Source="Nicolas_upshifts" /id="D1312" /incds=0 /nref=70 /ntot=220 /MaxReadThrough="6.60948" /MaxDrop="5.42847" /score="18.9025126" /energy="-23.3" /TU="U1972,U1973,U1975" /idTUdmin="U1976" /TUdmin=178 /isTUend="FALSE" /label="downshifts" promotor_-35 2305087..2305092 /Source="Nicolas_upshift_promotors" /id="U1971" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.955044955044955" /psig="0.955044955044955" /xcortree=959 /SigmaFactorBS="ctaaggtcgctttcatgaggtaaacgcaaGTACTTctttctc tcactgcaACATATTTTATAATAAATGatcatataaaaagatggaccaaatgtcaact t" /listShort="S956" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2305108..2305126 /Source="Nicolas_upshift_promotors" /id="U1971" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.955044955044955" /psig="0.955044955044955" /xcortree=959 /SigmaFactorBS="ctaaggtcgctttcatgaggtaaacgcaaGTACTTctttctc tcactgcaACATATTTTATAATAAATGatcatataaaaagatggaccaaatgtcaact t" /listShort="S956" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2305116..2305135) /Source="Nicolas_upshift_promotors" /id="U1972" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig=1 /xcortree=3007 /SigmaFactorBS="aagcatgaaacatcttatgggtgaaaacaaaAGTTGACAttt ggtccatctttTTATATGATCATTTATTATAaaatatgttgcagtgagagaaagaagt a" /listShort="NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="promotor_-10" S_feature 2305118..2306530 /Source="Nicolas_S_feature" /locus_tag="new_2608912_2610324" /HighExp="C30, S8, Gly, BT, G135, Fru, S6, C90, Lbstat, Mal" /AntisenseName="recO" /AntisenseCor="0.22892689952134901" /AntisenseRegPval="-3.8" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.955" /TUlongSig="NA" /TUlongPSig="NA" /label="S956" upshifts 2305118 /Source="Nicolas_upshifts" /id="U1971" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.955044955044955" /psig="0.955044955044955" /xcortree=959 /SigmaFactorBS="ctaaggtcgctttcatgaggtaaacgcaaGTACTTctttctc tcactgcaACATATTTTATAATAAATGatcatataaaaagatggaccaaatgtcaact t" /listShort="S956" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2305128) /Source="Nicolas_upshifts" /id="U1972" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig=1 /xcortree=3007 /SigmaFactorBS="aagcatgaaacatcttatgggtgaaaacaaaAGTTGACAttt ggtccatctttTTATATGATCATTTATTATAaaatatgttgcagtgagagaaagaagt a" /listShort="NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="upshifts" promotor_-35 complement(2305150..2305157) /Source="Nicolas_upshift_promotors" /id="U1972" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig=1 /xcortree=3007 /SigmaFactorBS="aagcatgaaacatcttatgggtgaaaacaaaAGTTGACAttt ggtccatctttTTATATGATCATTTATTATAaaatatgttgcagtgagagaaagaagt a" /listShort="NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /listLong="S947, S946, trmK, yqfO" /label="promotor_-35" CDS complement(2305152..2305919) /gene="recO" /locus_tag="BSU_25280" /old_locus_tag="BSU25280" /function="16.9: Replicate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10323239, 15186413, 16061691, 26001966" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10323239, 15186413, 16061691, 26001966; Product type f: factor" /codon_start=1 /transl_table=11 /product="DNA double strand break repair and homologous recombination factor" /protein_id="NP_390406.2" /db_xref="EnsemblGenomes-Gn:BSU25280" /db_xref="EnsemblGenomes-Tr:CAB14457" /db_xref="GOA:P42095" /db_xref="InterPro:IPR003717" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR022572" /db_xref="SubtiList:BG11189" /db_xref="UniProtKB/Swiss-Prot:P42095" /translation="MLTKCEGIVLRTNDYGETNKIVTLLTREHGKIGVMARGAKKPNS RLSAVSQPFLYGSFLMQKTSGLGTLQQGEMILSMRGIREDLFLTAYAAYVAELVDRGT EEKKPNPYLFEFILESLKQLNEGTDPDVITFIVQMKMLGVMGLYPELNHCVHCKSQDG TFHFSVRDNGFICHRCFEKDPYRIPIKPQTARLLRLFYYFDLSRLGNVSLKEETKAEL KQVIDLYYEEYSGLYLKSKRFLDQMESMKHLMGENKS*" /label="recO CDS" gene complement(2305152..2305919) /gene="recO" /locus_tag="BSU_25280" /old_locus_tag="BSU25280" /label="recO gene" CDS complement(2305956..2306099) /gene="yqzL" /locus_tag="BSU_25289" /old_locus_tag="BSU25289" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097761.1" /db_xref="EnsemblGenomes-Gn:BSU25289" /db_xref="EnsemblGenomes-Tr:CAX52661" /db_xref="InterPro:IPR025617" /db_xref="UniProtKB/Swiss-Prot:C0H452" /translation="MLNFTWNVFSQTGNVDTYLLFKELEKENMERPEELEDELARFDY PIL*" /label="yqzL CDS" gene complement(2305956..2306099) /gene="yqzL" /locus_tag="BSU_25289" /old_locus_tag="BSU25289" /label="yqzL gene" S_feature complement(2306100..2306246) /Source="Nicolas_S_feature" /locus_tag="new_2609894_2610040_c" /HighExp="Lbstat, T1.30H, T2.0H, M9-stat, S2, T3.0H, S5, M0t90, T2.30H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigB" /TUshortPSig="0.999, 0.998, 1" /TUlongSig="SigGF" /TUlongPSig="0.979" /label="S957" CDS complement(2306247..2307152) /gene="era" /locus_tag="BSU_25290" /old_locus_tag="BSU25290" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12399511, 12427945, 12682299, 21646538, 22720735, 27834201, 28132488" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12399511, 12427945, 12682299, 21646538, 22720735, 27834201, 28132488; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="maturation of 16S RNA and assembly of 30S ribosomal subunit GTPase" /protein_id="NP_390407.1" /db_xref="EnsemblGenomes-Gn:BSU25290" /db_xref="EnsemblGenomes-Tr:CAB14458" /db_xref="GOA:P42182" /db_xref="InterPro:IPR004044" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR005662" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR009019" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030388" /db_xref="SubtiList:BG11188" /db_xref="UniProtKB/Swiss-Prot:P42182" /translation="MTNESFKSGFVSIIGRPNVGKSTFLNRVIGQKIAIMSDKPQTTR NKVQGVLTTGTSQTIFIDTPGIHKPKHKLGDFMMKVAQNTLKEVDLILFMINAEEGYG KGDEFIIEKLQTMSTPVFLIVNKIDKIHPDQLLLLIDEYRKRYPFKEIVPISALEGNN IETLLAQIEAYLPEGPQFYPSDQVTDHPERFIISELIREKVLHLTREEIPHSIAVAIE SIKGQDNGSVHVAATIVVERDSQKGIVIGKKGSLLKEVGKRARADIEALLGSRVYLEL WVKVQKDWRNKMSQLRDFGFKEDEY*" /label="era CDS" gene complement(2306247..2307152) /gene="era" /locus_tag="BSU_25290" /old_locus_tag="BSU25290" /label="era gene" CDS complement(2307133..2307543) /gene="cdd" /locus_tag="BSU_25300" /old_locus_tag="BSU25300" /EC_number="3.5.4.5" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:2526291, 8157589, 10217788, 11851403, 22720735, 25890046" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2526291, 8157589, 10217788, 11851403, 22720735, 25890046; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cytidine/deoxycytidine deaminase" /protein_id="NP_390408.1" /db_xref="EnsemblGenomes-Gn:BSU25300" /db_xref="EnsemblGenomes-Tr:CAB14459" /db_xref="GOA:P19079" /db_xref="InterPro:IPR002125" /db_xref="InterPro:IPR006262" /db_xref="InterPro:IPR016192" /db_xref="InterPro:IPR016193" /db_xref="PDB:1JTK" /db_xref="PDB:1UWZ" /db_xref="PDB:1UX0" /db_xref="PDB:1UX1" /db_xref="SubtiList:BG10477" /db_xref="UniProtKB/Swiss-Prot:P19079" /translation="MNRQELITEALKARDMAYAPYSKFQVGAALLTKDGKVYRGCNIE NAAYSMCNCAERTALFKAVSEGDTEFQMLAVAADTPGPVSPCGACRQVISELCTKDVI VVLTNLQGQIKEMTVEELLPGAFSSEDLHDERKL*" /label="cdd CDS" gene complement(2307133..2307543) /gene="cdd" /locus_tag="BSU_25300" /old_locus_tag="BSU25300" /label="cdd gene" promotor_-10 complement(2307581..2307600) /Source="Nicolas_upshift_promotors" /id="U1973" /multdbtbs="SigA,SigB" /comp="M7" /sig="SigA" /pcomp="0.873126873126873" /psig="0.999000999001" /xcortree=528 /SigmaFactorBS="attcttacatttattttacatttttagaaatgggCGTGaaaa aaagcgcgcgATTATGTAAAATATAAAGTGatagcggtaccattataggtaagagagg a" /listShort="cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948" /listLong="cccA, S947, S946, trmK, yqfO" /label="promotor_-10" upshifts complement(2307592) /Source="Nicolas_upshifts" /id="U1973" /multdbtbs="SigA,SigB" /comp="M7" /sig="SigA" /pcomp="0.873126873126873" /psig="0.999000999001" /xcortree=528 /SigmaFactorBS="attcttacatttattttacatttttagaaatgggCGTGaaaa aaagcgcgcgATTATGTAAAATATAAAGTGatagcggtaccattataggtaagagagg a" /listShort="cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948" /listLong="cccA, S947, S946, trmK, yqfO" /label="upshifts" S_feature complement(2307594..2307661) /Source="Nicolas_S_feature" /locus_tag="new_2611388_2611455_c" /HighExp="Oxctl, H2O2, G180, G150, GM 120, S1, G135, Diami, LBGtran, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="0.998, 1" /TUlongSig="SigGF" /TUlongPSig="0.979" /label="S958" promotor_-35 complement(2307615..2307618) /Source="Nicolas_upshift_promotors" /id="U1973" /multdbtbs="SigA,SigB" /comp="M7" /sig="SigA" /pcomp="0.873126873126873" /psig="0.999000999001" /xcortree=528 /SigmaFactorBS="attcttacatttattttacatttttagaaatgggCGTGaaaa aaagcgcgcgATTATGTAAAATATAAAGTGatagcggtaccattataggtaagagagg a" /listShort="cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948" /listLong="cccA, S947, S946, trmK, yqfO" /label="promotor_-35" CDS complement(2307662..2308033) /gene="unpK" /locus_tag="BSU_25310" /old_locus_tag="BSU25310" /EC_number="2.7.1.66" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12923107, 17535816, 19935659, 28872301; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="undecaprenol kinase" /protein_id="NP_390409.2" /db_xref="EnsemblGenomes-Gn:BSU25310" /db_xref="EnsemblGenomes-Tr:CAB14460" /db_xref="GOA:P19638" /db_xref="InterPro:IPR000829" /db_xref="InterPro:IPR033717" /db_xref="InterPro:IPR036945" /db_xref="SubtiList:BG11040" /db_xref="UniProtKB/Swiss-Prot:P19638" /translation="MDSKDHRNELNRFFKSFVHAGRGIWETARTERNFQFHAAAACAV LICGFLVELSIIEWMIIFLLIGGMFSLELLNTAIEHTVDLITDKHHPLAKAAKDAAAG AVCVFAVISCIIGLLIFLPKL*" /label="unpK CDS" gene complement(2307662..2308033) /gene="unpK" /locus_tag="BSU_25310" /old_locus_tag="BSU25310" /label="unpK gene" CDS complement(2308014..2308487) /gene="rnrY" /locus_tag="BSU_25320" /old_locus_tag="BSU25320" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16511207, 16818608, 19181801, 20639334, 20807199, 23273979, 23638028, 24511998, 24901994, 28031281; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endonuclease involved in 70S ribosomes quality control" /protein_id="NP_390410.2" /db_xref="EnsemblGenomes-Gn:BSU25320" /db_xref="EnsemblGenomes-Tr:CAB14461" /db_xref="GOA:P46347" /db_xref="InterPro:IPR002036" /db_xref="InterPro:IPR020549" /db_xref="InterPro:IPR023091" /db_xref="SubtiList:BG11656" /db_xref="UniProtKB/Swiss-Prot:P46347" /translation="MSLLIDIVDETGSVSEEMLKEVENLLQFAAEREGVQDQAEVSVT IVSNDDIHQINKEYRGKDAPTDVISFALEEEGEGEIEIVGAEMPPVLGDIIISADRTR EQAEEYNHSFKRELGFLAVHGFLHLLGYDHMTKEEEEEMFTKQKELLDAYGLKRS*" /label="rnrY CDS" gene complement(2308014..2308487) /gene="rnrY" /locus_tag="BSU_25320" /old_locus_tag="BSU25320" /label="rnrY gene" CDS complement(2308488..2310623) /gene="pgpH" /locus_tag="BSU_25330" /old_locus_tag="BSU25330" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16751502, 26240071, 27378384" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16751502, 26240071, 27378384; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="c-di-AMP-degrading phosphodiesterases" /protein_id="NP_390411.1" /db_xref="EnsemblGenomes-Gn:BSU25330" /db_xref="EnsemblGenomes-Tr:CAB14462" /db_xref="GOA:P46344" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR006674" /db_xref="InterPro:IPR006675" /db_xref="InterPro:IPR011621" /db_xref="InterPro:IPR011624" /db_xref="SubtiList:BG11655" /db_xref="UniProtKB/Swiss-Prot:P46344" /translation="MLKKKAKTKSSSKKWSSFKNARSMHVLLYLLLAAIMFALLFVHV KPETLDLDLFSVSDKTIYAPATVEDQKATEEKKQAAEDAVEDQYTLKKEYTDNRIDLV SSIFDSISEVKKSSEEGSKSPSEKSMVKSVKDKLTSDVNDSISEDSIKTLLKADSEDF SFVRDTVITAVNTVMSSEIPSDKLSDAKDKVEKELKSNSIPSKYLGAATEIGRFAIIP NYVFDPKATEAKRQEASDNVQQVQIKQGQVLVEENDLIDREVYRKLELTGLLNNSNLF KPISGLLIMIGLFIATLVYYFEKQKQNLKFKNQSILLFSIITTLLLVIMEVVSLFQKM EYNNIGYLVPIAAGAILIKLLMNERIAILGSIILAICGSMMFNQGVTGTFNYVIGIYY LISGISGVLFLGKHNARSKILQTGLFVAFINMVVVLSLLLIQNTALSGLEIGTLMLMG VVSGFASSVLIIGLMPFFETGFGILSTMRLLELSNPNHPLLRKILTETPGTYHHSVMV ANLSEAACEAVGANGLLARVGAYYHDLGKTKRPQYFIENQMNIDNPHDKLSPQLSKNI IISHTTDGANMLRSYKFPKELVDIAEQHHGTSLLKFFYYKAKEKGDQITEEEFRYPGP KPQSKEAAIISVADSVEAAVRSMHNPNPERIEKLVRGIISDKLQDGQFSECDLTFKEL DTIAKTLCATLKGIFHSRIEYPEATKKVK*" /label="pgpH CDS" gene complement(2308488..2310623) /gene="pgpH" /locus_tag="BSU_25330" /old_locus_tag="BSU25330" /label="pgpH gene" promotor_-35 2310467..2310472 /Source="Nicolas_upshift_promotors" /id="U1974" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1188 /SigmaFactorBS="gttgccggagcgtaaatggtcttgtcgctgactgaaaacaGG TCTAaatcaagtgtttccgGCTTAACATGTACAAAGAGcaaagcaaacataatggcag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2310487 /Source="Nicolas_upshifts" /id="U1974" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1188 /SigmaFactorBS="gttgccggagcgtaaatggtcttgtcgctgactgaaaacaGG TCTAaatcaagtgtttccgGCTTAACATGTACAAAGAGcaaagcaaacataatggcag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2310488..2310506 /Source="Nicolas_upshift_promotors" /id="U1974" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1188 /SigmaFactorBS="gttgccggagcgtaaatggtcttgtcgctgactgaaaacaGG TCTAaatcaagtgtttccgGCTTAACATGTACAAAGAGcaaagcaaacataatggcag c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2310702..2311661) /gene="phoH" /locus_tag="BSU_25340" /old_locus_tag="BSU25340" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12762842" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12762842; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="phosphate starvation-induced protein" /protein_id="NP_390412.2" /db_xref="EnsemblGenomes-Gn:BSU25340" /db_xref="EnsemblGenomes-Tr:CAB14476" /db_xref="GOA:P46343" /db_xref="InterPro:IPR003714" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11337" /db_xref="UniProtKB/Swiss-Prot:P46343" /translation="MTEHLLAMNQKLKNPDEALSLFGNQDSFLKLMEKDLNLNIITRG ETIYVSGDDESFQIADRLLGSLLALIRKGIEISERDVIYAIKMAKKNELEYFESMYEE EITKNAKGKSIRVKTMGQREYVAAMKRNDLVFGIGPAGTGKTYLAVVKAVHALKNGHI KKIILTRPAVEAGESLGFLPGDLKEKVDPYLRPLYDALHDVLGADHTERLMERGIIEI APLAYMRGRTLDDAYVILDEAQNTTPAQMKMFLTRLGFGSKMIITGDVSQIDLPKGVK SGLAVAKEMLKGIDGISMIELDQTDVVRHPLVAKIIEAYDKQN*" /label="phoH CDS" gene complement(2310702..2311661) /gene="phoH" /locus_tag="BSU_25340" /old_locus_tag="BSU25340" /label="phoH gene" downshifts complement(2310717) /Source="Nicolas_upshifts" /id="D1313" /incds=0 /nref=1 /ntot=63 /MaxReadThrough="6.04676" /MaxDrop="4.50442" /score="9.12152318" /energy="-13.1" /TU="U1975,U1976,U1977" /idTUdmin="U1978" /TUdmin=1034 /isTUend="FALSE" /label="downshifts" CDS complement(2311658..2312854) /gene="yqfD" /locus_tag="BSU_25350" /old_locus_tag="BSU25350" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14523133, 26735940; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="stage IV sporulation protein; putative UDP-glucose-4-epimerase" /protein_id="NP_390413.2" /db_xref="EnsemblGenomes-Gn:BSU25350" /db_xref="EnsemblGenomes-Tr:CAB14477" /db_xref="GOA:P54469" /db_xref="InterPro:IPR010690" /db_xref="SubtiList:BG11654" /db_xref="UniProtKB/Swiss-Prot:P54469" /translation="MKNKWLSFFSGKVQLELTGRGIERLLNECTRQGIPVFHVKKKKE AVSLYIQLQDVHAFRRVRSKFKCKARFINRKGFPFLLLKSKLNIGFTIGFAIFFILLF LLSNMVWKIDVTGAKPETEHQMRQHLNEIGVKKGRLQFLMMSPEKIQKSLTNGIDNIT WVGVDLKGTTIHMKVVEKNEPEKEKYVSPRNIVAKKKATITRMFVQKGQPMAAIHDHV EKGQLLVSGLIGSEDHQQEVASKAEIYGETWYRSEVTVPLETLFNVYTGKVRTKHKLS FGSLAIPIWGMTFKKEELKHPKTEQEKHSLHFLGFKLPVSYVKEQTRESEEALRKYTK EEAVQEGIKLGKQDVEDKIGENGEVKSEKVLHQTVENGKVKLIILYQVIEDIVQTTPI VRETEE*" /label="yqfD CDS" gene complement(2311658..2312854) /gene="yqfD" /locus_tag="BSU_25350" /old_locus_tag="BSU25350" /label="yqfD gene" promotor_-10 complement(2311725..2311744) /Source="Nicolas_upshift_promotors" /id="U1975" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.493506493506494" /psig="0.998001998001998" /xcortree=609 /SigmaFactorBS="aaacggcgaggtgaaaagtgaaaaaGTTTTGCAccagactgt tgagAATGGTAAAGTAAAGTTGATtattctctaccaagttatagaagatatcgttcaa a" /listShort="phoH, yqfF, yqfG, dgkA, S958, cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL" /listLong="S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA, S947, S946, trmK, yqfO" /label="promotor_-10" upshifts complement(2311730) /Source="Nicolas_upshifts" /id="U1975" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.493506493506494" /psig="0.998001998001998" /xcortree=609 /SigmaFactorBS="aaacggcgaggtgaaaagtgaaaaaGTTTTGCAccagactgt tgagAATGGTAAAGTAAAGTTGATtattctctaccaagttatagaagatatcgttcaa a" /listShort="phoH, yqfF, yqfG, dgkA, S958, cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL" /listLong="S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA, S947, S946, trmK, yqfO" /label="upshifts" promotor_-35 complement(2311758..2311765) /Source="Nicolas_upshift_promotors" /id="U1975" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.493506493506494" /psig="0.998001998001998" /xcortree=609 /SigmaFactorBS="aaacggcgaggtgaaaagtgaaaaaGTTTTGCAccagactgt tgagAATGGTAAAGTAAAGTTGATtattctctaccaagttatagaagatatcgttcaa a" /listShort="phoH, yqfF, yqfG, dgkA, S958, cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL" /listLong="S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA, S947, S946, trmK, yqfO" /label="promotor_-35" promotor_-10 complement(2311805..2311823) /Source="Nicolas_upshift_promotors" /id="U1976" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=741 /SigmaFactorBS="agaggctttgcgaaaatatacaaaagaagaagcAGTTCAAga aggcattaaattGGGTAAACAGGATGTAGAGgataaaataggcgaaaacggcgaggtg a" /listShort="phoH, yqfF, yqfG, dgkA, S958, cdd, era, S957, yqzL, recO" /listLong="NA, glyQ, glyS" /label="promotor_-10" upshifts complement(2311817) /Source="Nicolas_upshifts" /id="U1976" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=741 /SigmaFactorBS="agaggctttgcgaaaatatacaaaagaagaagcAGTTCAAga aggcattaaattGGGTAAACAGGATGTAGAGgataaaataggcgaaaacggcgaggtg a" /listShort="phoH, yqfF, yqfG, dgkA, S958, cdd, era, S957, yqzL, recO" /listLong="NA, glyQ, glyS" /label="upshifts" promotor_-35 complement(2311838..2311844) /Source="Nicolas_upshift_promotors" /id="U1976" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=741 /SigmaFactorBS="agaggctttgcgaaaatatacaaaagaagaagcAGTTCAAga aggcattaaattGGGTAAACAGGATGTAGAGgataaaataggcgaaaacggcgaggtg a" /listShort="phoH, yqfF, yqfG, dgkA, S958, cdd, era, S957, yqzL, recO" /listLong="NA, glyQ, glyS" /label="promotor_-35" upshifts complement(2312032) /Source="Nicolas_upshifts" /id="U1977" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=910 /SigmaFactorBS="acagtcccgcttgaAACATTAtttaacgtctatacGGGCAAA GTAAGgacaaagcacaagctttcttttggttctttggcaatcccgatctgggggatga c" /listShort="phoH, yqfF, yqfG, dgkA" /listLong="S958, cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /label="upshifts" promotor_-10 complement(2312046..2312057) /Source="Nicolas_upshift_promotors" /id="U1977" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=910 /SigmaFactorBS="acagtcccgcttgaAACATTAtttaacgtctatacGGGCAAA GTAAGgacaaagcacaagctttcttttggttctttggcaatcccgatctgggggatga c" /listShort="phoH, yqfF, yqfG, dgkA" /listLong="S958, cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /label="promotor_-10" promotor_-35 complement(2312072..2312078) /Source="Nicolas_upshift_promotors" /id="U1977" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=910 /SigmaFactorBS="acagtcccgcttgaAACATTAtttaacgtctatacGGGCAAA GTAAGgacaaagcacaagctttcttttggttctttggcaatcccgatctgggggatga c" /listShort="phoH, yqfF, yqfG, dgkA" /listLong="S958, cdd, era, S957, yqzL, recO, NA, glyQ, glyS, S955, ccpN, yqfL, S954, S953, yqxD, dnaG, S952, sigA, S949, S948, cccA" /label="promotor_-35" CDS complement(2312873..2313154) /gene="yqfC" /locus_tag="BSU_25360" /old_locus_tag="BSU25360" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12662922" /codon_start=1 /transl_table=11 /product="conserved sporulation protein of unknown function" /protein_id="NP_390414.1" /db_xref="EnsemblGenomes-Gn:BSU25360" /db_xref="EnsemblGenomes-Tr:CAB14478" /db_xref="InterPro:IPR022476" /db_xref="InterPro:IPR022477" /db_xref="SubtiList:BG11653" /db_xref="UniProtKB/Swiss-Prot:P54468" /translation="MGQRKNRMKAWLTRALEIPPDVMMDLPRITMVGRLHIYIENHRG LLLFSENEVRLMLKQGQCIISGKNFVIKAILPEEILLEGTIDVVRYVES*" /label="yqfC CDS" gene complement(2312873..2313154) /gene="yqfC" /locus_tag="BSU_25360" /old_locus_tag="BSU25360" /label="yqfC gene" CDS complement(2313211..2313630) /gene="yqfB" /locus_tag="BSU_25370" /old_locus_tag="BSU25370" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390415.2" /db_xref="EnsemblGenomes-Gn:BSU25370" /db_xref="EnsemblGenomes-Tr:CAB14479" /db_xref="GOA:P54467" /db_xref="InterPro:IPR016788" /db_xref="SubtiList:BG11652" /db_xref="UniProtKB/Swiss-Prot:P54467" /translation="MEDLLTNPLIIAAIIGIISAIFGKKSKEEKQNSQKRKKPQHVQS ASPQKKQSKEDAPAPIPNRMEQARREAEERRRETARNLKGLERDLAAAKQKTVYTKQK MLQVNKDTVVQGIVLGEVFGPPRAKKPHRTMRPARKN*" /label="yqfB CDS" gene complement(2313211..2313630) /gene="yqfB" /locus_tag="BSU_25370" /old_locus_tag="BSU25370" /label="yqfB gene" downshifts complement(2313225) /Source="Nicolas_upshifts" /id="D1314" /incds=0 /nref=232 /ntot=257 /MaxReadThrough="4.55662" /MaxDrop="7.47609" /score="-3.87904232" /energy="-16.8" /TU="U1978" /idTUdmin="U1980" /TUdmin=242 /isTUend="FALSE" /label="downshifts" CDS complement(2313655..2314650) /gene="floA" /locus_tag="BSU_25380" /old_locus_tag="BSU25380" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:12501411, 22753055" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12501411, 22753055; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="flotillin-like protein involved in membrane lipid rafts" /protein_id="NP_390416.1" /db_xref="EnsemblGenomes-Gn:BSU25380" /db_xref="EnsemblGenomes-Tr:CAB14480" /db_xref="GOA:P54466" /db_xref="InterPro:IPR022853" /db_xref="SubtiList:BG11651" /db_xref="UniProtKB/Swiss-Prot:P54466" /translation="MDPSTLMILAIVAVAIIVLAVFFTFVPVMLWISALAAGVKISIF TLVGMRLRRVIPNRVVNPLIKAHKAGLNVGTNQLESHYLAGGNVDRVVNALIAAQRAN IELTFERCAAIDLAGRDVLEAVQMSVNPKVIETPFIAGVAMDGIEVKAKARITVRANI ERLVGGAGEETIVARVGEGIVSTIGSSDNHKKVLENPDMISQTVLGKGLDSGTAFEIL SIDIADVDIGKNIGAILQTDQAEADKNIAQAKAEERRAMAVAQEQEMRARVEEMRAKV VEAEAEVPLAMAEALREGNIGVMDYMNIKNIDADTEMRDSFGKLTKDPSDEDRKS*" /label="floA CDS" gene complement(2313655..2314650) /gene="floA" /locus_tag="BSU_25380" /old_locus_tag="BSU25380" /label="floA gene" CDS complement(2314672..2315985) /gene="nfeDA" /locus_tag="BSU_25390" /old_locus_tag="BSU25390" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735, 22753055; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane bound peptidase of unkwnown function" /protein_id="NP_390417.1" /db_xref="EnsemblGenomes-Gn:BSU25390" /db_xref="EnsemblGenomes-Tr:CAB14481" /db_xref="GOA:P54465" /db_xref="InterPro:IPR002810" /db_xref="InterPro:IPR002825" /db_xref="InterPro:IPR029045" /db_xref="SubtiList:BG11650" /db_xref="UniProtKB/Swiss-Prot:P54465" /translation="MLQIKGFRAALLGIFLLSLLGVQLNAKAEKQTVYVIPVEKNVEQ GLASFLSRSLQDAKDAHADHIILDINTPGGLVKSAIDMADLITESEIPVTAYVNKRAL SAGAYIALQADHIYMAPGGKMGAAAIVDGQGNAADQKAQSLWLAEMEDAAVKNNRDPK YALAMADPDIDAKEVGAPKGDLLTLNADKAIEVGYSEGTADNLSTLVKKLGFEKAQIS YAKESFAEKTARWLTNPVIVPILLTIAFLGLTVELFSPGVGLPGTAGLIALLLFFYGH LAAGLAGYETVLLFIAGVILILLEIFLPGGIIGLLGLGAIIASLFLAAGSFTVMAVSL LIASAVSITAFILLTRVLGKRMKFFKKLILNDSTNTESGYVSNQTRTDLMGKVGITFT PLRPSGTVIIDDERLDVVSEGSFTEKDKKVKVIKVEGSRIVVREI*" /label="nfeDA CDS" gene complement(2314672..2315985) /gene="nfeDA" /locus_tag="BSU_25390" /old_locus_tag="BSU25390" /label="nfeDA gene" promotor_-10 complement(2316021..2316036) /Source="Nicolas_upshift_promotors" /id="U1978" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1696 /SigmaFactorBS="atctttctaagagagatgtctttttttatacataaaaaaaTG AAACCTTTgatacatttgttACGTATGAAGAGAAGGcacttattataaaaggaaggag g" /listShort="yqeZ, yqfA, yqfB, yqfC, yqfD" /listLong="phoH, yqfF, yqfG" /label="promotor_-10" upshifts complement(2316038) /Source="Nicolas_upshifts" /id="U1978" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1696 /SigmaFactorBS="atctttctaagagagatgtctttttttatacataaaaaaaTG AAACCTTTgatacatttgttACGTATGAAGAGAAGGcacttattataaaaggaaggag g" /listShort="yqeZ, yqfA, yqfB, yqfC, yqfD" /listLong="phoH, yqfF, yqfG" /label="upshifts" promotor_-35 complement(2316049..2316058) /Source="Nicolas_upshift_promotors" /id="U1978" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1696 /SigmaFactorBS="atctttctaagagagatgtctttttttatacataaaaaaaTG AAACCTTTgatacatttgttACGTATGAAGAGAAGGcacttattataaaaggaaggag g" /listShort="yqeZ, yqfA, yqfB, yqfC, yqfD" /listLong="phoH, yqfF, yqfG" /label="promotor_-35" CDS complement(2316116..2316562) /gene="yqeY" /locus_tag="BSU_25400" /old_locus_tag="BSU25400" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 17284460, 22720735, 25149203" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function with tRNA aminoacid amidase domain" /protein_id="NP_390418.1" /db_xref="EnsemblGenomes-Gn:BSU25400" /db_xref="EnsemblGenomes-Tr:CAB14482" /db_xref="GOA:P54464" /db_xref="InterPro:IPR003789" /db_xref="InterPro:IPR019004" /db_xref="InterPro:IPR023168" /db_xref="PDB:1NG6" /db_xref="SubtiList:BG11649" /db_xref="UniProtKB/Swiss-Prot:P54464" /translation="MSLLERLNQDMKLYMKNREKDKLTVVRMVKASLQNEAIKLKKDS LTEDEELTVLSRELKQRKDSLQEFSNANRLDLVDKVQKELDILEVYLPEQLSEEELRT IVNETIAEVGASSKADMGKVMGAIMPKVKGKADGSLINKLVSSQLS*" /label="yqeY CDS" gene complement(2316116..2316562) /gene="yqeY" /locus_tag="BSU_25400" /old_locus_tag="BSU25400" /label="yqeY gene" downshifts complement(2316129) /Source="Nicolas_upshifts" /id="D1315" /incds=0 /nref=248 /ntot=267 /MaxReadThrough="5.1355" /MaxDrop="8.31948" /score="17.2548348" /energy="-10.3" /TU="U1980" /idTUdmin="U1983" /TUdmin=1760 /isTUend="FALSE" /label="downshifts" downshifts complement(2316327) /Source="Nicolas_upshifts" /id="D1316" /incds=1 /nref=1 /ntot=34 /MaxReadThrough="8.99916" /MaxDrop="1.9798" /score="17.2548348" /energy="-10.3" /TU="U1980" /idTUdmin="U1983" /TUdmin=1562 /isTUend="FALSE" /label="downshifts" CDS complement(2316577..2316750) /gene="rpsU" /locus_tag="BSU_25410" /old_locus_tag="BSU25410" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 22720735, 23002217, 25035996" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 22720735, 23002217, 25035996; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S21" /protein_id="NP_390419.1" /db_xref="EnsemblGenomes-Gn:BSU25410" /db_xref="EnsemblGenomes-Tr:CAB14483" /db_xref="GOA:P21478" /db_xref="InterPro:IPR001911" /db_xref="InterPro:IPR018278" /db_xref="SubtiList:BG11648" /db_xref="UniProtKB/Swiss-Prot:P21478" /translation="MSKTVVRKNESLEDALRRFKRSVSKTGTLQEARKREFYEKPSVK RKKKSEAARKRKF*" /label="rpsU CDS" gene complement(2316577..2316750) /gene="rpsU" /locus_tag="BSU_25410" /old_locus_tag="BSU25410" /label="rpsU gene" misc_feature 2316686..2316690 /Source="Nicolas_upshift_promotors" /id="U1979" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.877122877122877" /psig="0.113886113886114" /xcortree=55 /SigmaFactorBS="tttttcataaaattcacgctttcttgcttcttgcaaagtacc tgtctttgatacaCTGCGtttgaagcgacgaagagcatcttcaagcgattcgtttttt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2316691 /Source="Nicolas_upshifts" /id="U1979" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.877122877122877" /psig="0.113886113886114" /xcortree=55 /SigmaFactorBS="tttttcataaaattcacgctttcttgcttcttgcaaagtacc tgtctttgatacaCTGCGtttgaagcgacgaagagcatcttcaagcgattcgtttttt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2316811..2316830) /Source="Nicolas_upshift_promotors" /id="U1980" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.547452547452547" /psig="0.998001998001998" /xcortree=2702 /SigmaFactorBS="ggcagtcgcactcatgacggaaaagtgaactcactTAGTTGA CctgactgatggctTATATTATAATGTCAAAGTAcatgtttatatgtgtaacttaaag g" /listShort="rpsU, yqeY, yqeZ, yqfA, yqfB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2316826) /Source="Nicolas_upshifts" /id="U1980" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.547452547452547" /psig="0.998001998001998" /xcortree=2702 /SigmaFactorBS="ggcagtcgcactcatgacggaaaagtgaactcactTAGTTGA CctgactgatggctTATATTATAATGTCAAAGTAcatgtttatatgtgtaacttaaag g" /listShort="rpsU, yqeY, yqeZ, yqfA, yqfB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2316844..2316851) /Source="Nicolas_upshift_promotors" /id="U1980" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.547452547452547" /psig="0.998001998001998" /xcortree=2702 /SigmaFactorBS="ggcagtcgcactcatgacggaaaagtgaactcactTAGTTGA CctgactgatggctTATATTATAATGTCAAAGTAcatgtttatatgtgtaacttaaag g" /listShort="rpsU, yqeY, yqeZ, yqfA, yqfB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2316869..2316874 /Source="Nicolas_upshift_promotors" /id="U1981" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=971 /SigmaFactorBS="taagccatcagtcaggtcaactaagtgagttcacttttccGT CATGagtgcgactgcctgtCTATATAATGAAAGAAAGGggttggtgaataggatgtta a" /listShort="yqeW" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2316889 /Source="Nicolas_upshifts" /id="U1981" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=971 /SigmaFactorBS="taagccatcagtcaggtcaactaagtgagttcacttttccGT CATGagtgcgactgcctgtCTATATAATGAAAGAAAGGggttggtgaataggatgtta a" /listShort="yqeW" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2316890..2316908 /Source="Nicolas_upshift_promotors" /id="U1981" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=971 /SigmaFactorBS="taagccatcagtcaggtcaactaagtgagttcacttttccGT CATGagtgcgactgcctgtCTATATAATGAAAGAAAGGggttggtgaataggatgtta a" /listShort="yqeW" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2316923..2317846 /gene="yqeW" /locus_tag="BSU_25420" /old_locus_tag="BSU25420" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative Na+/anion cotransporter" /protein_id="NP_390420.2" /db_xref="EnsemblGenomes-Gn:BSU25420" /db_xref="EnsemblGenomes-Tr:CAB14484" /db_xref="GOA:P54463" /db_xref="InterPro:IPR003841" /db_xref="InterPro:IPR004633" /db_xref="SubtiList:BG11647" /db_xref="UniProtKB/Swiss-Prot:P54463" /translation="MLILISFTALILFFLAGMNMLRKGLISMAYSKIEERLLLFTDHP LKAFLISIVFTGILQSSSAFMVIVIGFVSAGVLSFKRTIPMILGTNVGSTFTTEFIAI KMDIVIWVLLIGGLLFFLTGRYPLKQLGTSFLGLGIIFFCISGFSHLAGPLTKLKTGA DVLYHVNDSNWSALLIGMVLTAIIHSSSVCIGILMSFMNEGIIGLTQAMSVVLGSNIG TCITAVMAAVSGGYAAKQTAYAHVVFNVLGVALVLPFLTAATGFVEQLSPDPAQKIAH FSLLFNVVTALLFLPLTNLFYRLIHLLIPAK*" /label="yqeW CDS" gene 2316923..2317846 /gene="yqeW" /locus_tag="BSU_25420" /old_locus_tag="BSU25420" /label="yqeW gene" CDS complement(2317883..2319238) /gene="mtaB" /locus_tag="BSU_25430" /old_locus_tag="BSU25430" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6163767, 9023197, 10572129, 15339930, 18252828, 8844851, 20472640, 20584901, 27913733" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6163767, 9023197, 10572129, 15339930, 18252828, 8844851, 20472640, 20584901, 27913733; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA N(6)-threonylcarbamoyladenosine (t(6)A) methylthiotransferase" /protein_id="NP_390421.1" /db_xref="EnsemblGenomes-Gn:BSU25430" /db_xref="EnsemblGenomes-Tr:CAB14485" /db_xref="GOA:P54462" /db_xref="InterPro:IPR002792" /db_xref="InterPro:IPR005839" /db_xref="InterPro:IPR006467" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013848" /db_xref="InterPro:IPR020612" /db_xref="InterPro:IPR023404" /db_xref="InterPro:IPR034557" /db_xref="SubtiList:BG11646" /db_xref="UniProtKB/Swiss-Prot:P54462" /translation="MATVAFHTLGCKVNHYETEAIWQLFKEAGYERRDFEQTADVYVI NTCTVTNTGDKKSRQVIRRAIRQNPDGVICVTGCYAQTSPAEIMAIPGVDIVVGTQDR EKMLGYIDQYREERQPINGVSNIMKARVYEELDVPAFTDRTRASLKIQEGCNNFCTFC IIPWARGLLRSRDPEEVIKQAQQLVDAGYKEIVLTGIHTGGYGEDMKDYNFAKLLSEL DTRVEGVKRIRISSIEASQITDEVIEVLDRSDKIVNHLHIPIQSGSNTVLKRMRRKYT MEFFADRLNKLKKALPGLAVTSDVIVGFPGETEEEFMETYNFIKEHKFSELHVFPYSK RTGTPAARMEDQVDENVKNERVHRLIALSDQLAKEYASQYENEVLEIIPEEAFKETEE ENMFVGYTDNYMKVVFKGTEDMIGKIVKVKILKAGYPYNEGQFVRVVEDEITEHMRLS S*" /label="mtaB CDS" gene complement(2317883..2319238) /gene="mtaB" /locus_tag="BSU_25430" /old_locus_tag="BSU25430" /label="mtaB gene" downshifts complement(2317889) /Source="Nicolas_upshifts" /id="D1317" /incds=0 /nref=208 /ntot=260 /MaxReadThrough="1.95578" /MaxDrop="6.05381" /score="30.7201786" /energy="-11.3" /TU="NA" /idTUdmin="U1983" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2319238..2320008) /gene="rsmE" /locus_tag="BSU_25440" /old_locus_tag="BSU25440" /EC_number="2.1.1.193" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9023197, 10383760, 14517985, 16014871, 16431987, 22925577, 24598751; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylase of U1498 in 16S rRNA" /protein_id="NP_390422.1" /db_xref="EnsemblGenomes-Gn:BSU25440" /db_xref="EnsemblGenomes-Tr:CAB14486" /db_xref="GOA:P54461" /db_xref="InterPro:IPR006700" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR029026" /db_xref="InterPro:IPR029028" /db_xref="PDB:1VHK" /db_xref="SubtiList:BG11645" /db_xref="UniProtKB/Swiss-Prot:P54461" /translation="MQRYFIELTKQQIEEAPTFSITGEEVHHIVNVMRMNEGDQIICC SQDGFEAKCELQSVSKDKVSCLVIEWTNENRELPIKVYIASGLPKGDKLEWIIQKGTE LGAHAFIPFQAARSVVKLDDKKAKKKRERWTKIAKEAAEQSYRNEVPRVMDVHSFQQL LQRMQDFDKCVVAYEESSKQGEISAFSAIVSSLPKGSSLLIVFGPEGGLTEAEVERLT EQDGVTCGLGPRILRTETAPLYALSAISYQTELLRGDQ*" /label="rsmE CDS" gene complement(2319238..2320008) /gene="rsmE" /locus_tag="BSU_25440" /old_locus_tag="BSU25440" /label="rsmE gene" CDS complement(2320031..2320966) /gene="prmA" /locus_tag="BSU_25450" /old_locus_tag="BSU25450" /EC_number="2.1.1.-" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17215866, 18611379; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribosomal protein L11 methyltransferase" /protein_id="NP_390423.2" /db_xref="EnsemblGenomes-Gn:BSU25450" /db_xref="EnsemblGenomes-Tr:CAB14487" /db_xref="GOA:P54460" /db_xref="InterPro:IPR004498" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11644" /db_xref="UniProtKB/Swiss-Prot:P54460" /translation="MKWSELSIHTTHEAVEPISNILHEAGASGVVIEDPLDLIKEREN VYGEIYQLDPNDYPDEGVIVKAYLPVNSFLGETVDGIKETINNLLLYNIDLGRNHITI SEVNEEEWATAWKKYYHPVKISEKFTIVPTWEEYTPVHTDELIIEMDPGMAFGTGTHP TTVLCIQALERFVQKGDKVIDVGTGSGILSIAAAMLEAESVHAYDLDPVAVESARLNL KLNKVSDIAQVKQNNLLDGIEGEHDVIVANILAEVILRFTSQAYSLLKEGGHFITSGI IGHKKQEVKEALEQAGFTIVEILSMEDWVSIIAKK*" /label="prmA CDS" gene complement(2320031..2320966) /gene="prmA" /locus_tag="BSU_25450" /old_locus_tag="BSU25450" /label="prmA gene" CDS complement(2320991..2322118) /gene="dnaJ" /locus_tag="BSU_25460" /old_locus_tag="BSU25460" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10383760, 10658654, 16385044, 16952052" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10383760, 10658654, 16385044, 16952052; Product type f: factor" /codon_start=1 /transl_table=11 /product="co-factor of molecular chaperone" /protein_id="NP_390424.2" /db_xref="EnsemblGenomes-Gn:BSU25460" /db_xref="EnsemblGenomes-Tr:CAB14488" /db_xref="GOA:P17631" /db_xref="InterPro:IPR001305" /db_xref="InterPro:IPR001623" /db_xref="InterPro:IPR002939" /db_xref="InterPro:IPR008971" /db_xref="InterPro:IPR012724" /db_xref="InterPro:IPR018253" /db_xref="InterPro:IPR036410" /db_xref="InterPro:IPR036869" /db_xref="SubtiList:BG10665" /db_xref="UniProtKB/Swiss-Prot:P17631" /translation="MSKRDYYEVLGVSKSASKDEIKKAYRKLSKKYHPDINKEAGSDE KFKEVKEAYETLSDDQKRAHYDQFGHTDPNQGFGGGGFGGGDFGGFGFDDIFSSIFGG GTRRRDPNAPRQGADLQYTMTLSFEDAAFGKETTIEIPREETCETCKGSGAKPGTNPE TCSHCGGSGQLNVEQNTPFGKVVNRRVCHHCEGTGKIIKNKCADCGGKGKIKKRKKIN VTIPAGVDDGQQLRLSGQGEPGINGGPAGDLFVVFHVRAHEFFERDGDDIYCEMPLTF AQAALGDEVEVPTLHGKVKLKIPAGTQTGTKFRLRGKGVQNVRGYGQGDQHIVVRVVT PTNLTDKQKDIIREFAEVSGNLPDEQEMSFFDKVKRAFKGD*" /label="dnaJ CDS" gene complement(2320991..2322118) /gene="dnaJ" /locus_tag="BSU_25460" /old_locus_tag="BSU25460" /label="dnaJ gene" misc_feature 2322035..2322038 /Source="Nicolas_upshift_promotors" /id="U1982" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.966033966033966" /psig="0.014985014985015" /xcortree=39 /SigmaFactorBS="tttcatctgatccggcttctttgttaatatcaggatgatatt tttttgaCAGCttccgataagcttttttaatttcatcctttgaagcgctcttacttac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2322046 /Source="Nicolas_upshifts" /id="U1982" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.966033966033966" /psig="0.014985014985015" /xcortree=39 /SigmaFactorBS="tttcatctgatccggcttctttgttaatatcaggatgatatt tttttgaCAGCttccgataagcttttttaatttcatcctttgaagcgctcttacttac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2322119..2322296) /Source="Nicolas_S_feature" /locus_tag="new_2625913_2626090_c" /HighExp="Heat, dia15, H2O2, Diami, G135, G150, G180, LPhT, Etha, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.357489" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="SigGF" /TUlongPSig="0.978" /label="S959" misc_RNA 2322158..2322248 /gene="surC" /locus_tag="BSU_misc_RNA_79" /product="sporulation-related small untranslated RNA" /experiment="publication(s) with functional evidences, PMID:16385044" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16385044; Product type n: RNA" /label="surC RNA" gene 2322158..2322248 /gene="surC" /locus_tag="BSU_misc_RNA_79" /label="surC gene" CDS complement(2322318..2324153) /gene="dnaK" /locus_tag="BSU_25470" /old_locus_tag="BSU25470" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10074100, 12224648, 12799007, 17407764, 22938038, 25355936, 27148221" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10074100, 12224648, 12799007, 17407764, 22938038, 25355936, 27148221; Product type f: factor" /codon_start=1 /transl_table=11 /product="molecular chaperone, ATP-dependent" /protein_id="NP_390425.1" /db_xref="EnsemblGenomes-Gn:BSU25470" /db_xref="EnsemblGenomes-Tr:CAB14489" /db_xref="GOA:P17820" /db_xref="InterPro:IPR012725" /db_xref="InterPro:IPR013126" /db_xref="InterPro:IPR018181" /db_xref="InterPro:IPR029047" /db_xref="InterPro:IPR029048" /db_xref="PDB:2FZO" /db_xref="SubtiList:BG10664" /db_xref="UniProtKB/Swiss-Prot:P17820" /translation="MSKVIGIDLGTTNSCVAVLEGGEPKVIANAEGNRTTPSVVAFKN GERQVGEVAKRQSITNPNTIMSIKRHMGTDYKVEIEGKDYTPQEVSAIILQHLKSYAE SYLGETVSKAVITVPAYFNDAERQATKDAGKIAGLEVERIINEPTAAALAYGLDKTDE DQTILVYDLGGGTFDVSILELGDGVFEVRSTAGDNRLGGDDFDQVIIDHLVSEFKKEN GIDLSKDKMALQRLKDAAEKAKKDLSGVSSTQISLPFITAGEAGPLHLELTLTRAKFE ELSSHLVERTMGPVRQALQDAGLSASEIDKVILVGGSTRIPAVQEAIKKETGKEAHKG VNPDEVVALGAAIQGGVITGDVKDVVLLDVTPLSLGIETMGGVFTKLIDRNTTIPTSK SQVFSTAADNQTAVDIHVLQGERPMSADNKTLGRFQLTDIPPAPRGVPQIEVSFDIDK NGIVNVRAKDLGTGKEQNITIKSSSGLSDEEIERMVKEAEENADADAKKKEEIEVRNE ADQLVFQTEKTLKDLEGKVDEEQVKKANDAKDALKAAIEKNEFEEIKAKKDELQTIVQ ELSMKLYEEAAKAQQAQGGANAEGKADDNVVDAEYEEVNDDQNKK*" /label="dnaK CDS" gene complement(2322318..2324153) /gene="dnaK" /locus_tag="BSU_25470" /old_locus_tag="BSU25470" /label="dnaK gene" downshifts complement(2322341) /Source="Nicolas_upshifts" /id="D1318" /incds=0 /nref=130 /ntot=247 /MaxReadThrough="8.0737" /MaxDrop="4.023" /score="21.9400858" /energy="-13.4" /TU="U1983,U1985" /idTUdmin="U1984" /TUdmin=3565 /isTUend="FALSE" /label="downshifts" CDS complement(2324177..2324740) /gene="grpE" /locus_tag="BSU_25480" /old_locus_tag="BSU25480" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9303302, 10383760, 12682299, 17289679, 21546913, 22720735, 22938038, 26913285" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9303302, 10383760, 12682299, 17289679, 21546913, 22720735, 22938038, 26913285; Product type r: regulator" /codon_start=1 /transl_table=11 /product="nucleotide exchange factor for DnaK activity" /protein_id="NP_390426.1" /db_xref="EnsemblGenomes-Gn:BSU25480" /db_xref="EnsemblGenomes-Tr:CAB14490" /db_xref="GOA:P15874" /db_xref="InterPro:IPR000740" /db_xref="InterPro:IPR009012" /db_xref="InterPro:IPR013805" /db_xref="PDB:2G61" /db_xref="SubtiList:BG10663" /db_xref="UniProtKB/Swiss-Prot:P15874" /translation="MSEEKQTVEQNETEEQEIIEEQAAADEQQEETNESELLQNQINE LQGLLEEKENKLLRVQADFENYKRRSRLEMEASQKYRSQNIVTDLLPALDSFERALQV EADNEQTKSLLQGMEMVHRQLVEALKKEGVEAIEAVGQEFDPNLHQAVMQAEDENYGS NIVVEEMQKGYKLKDRVIRPSMVKVNQ*" /label="grpE CDS" gene complement(2324177..2324740) /gene="grpE" /locus_tag="BSU_25480" /old_locus_tag="BSU25480" /label="grpE gene" S_feature complement(2324741..2324811) /Source="Nicolas_S_feature" /locus_tag="new_2628535_2628605_c" /HighExp="LPhT, dia15, Heat, Etha, Diami, dia5, H2O2, T-0.40H, T0.30H, T0.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="SigGF" /TUlongPSig="0.978" /label="S960" CDS complement(2324812..2325843) /gene="hrcA" /locus_tag="BSU_25490" /old_locus_tag="BSU25490" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10555317, 12082092, 15109714, 16872404, 16585746, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10555317, 12082092, 15109714, 16872404, 16585746, 22720735; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of heat-shock genes" /protein_id="NP_390427.1" /db_xref="EnsemblGenomes-Gn:BSU25490" /db_xref="EnsemblGenomes-Tr:CAB14491" /db_xref="GOA:P25499" /db_xref="InterPro:IPR002571" /db_xref="InterPro:IPR021153" /db_xref="InterPro:IPR029016" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10662" /db_xref="UniProtKB/Swiss-Prot:P25499" /translation="MLTNRQLLILQVIINDFIKSAQPVGSRTLSKKDEITFSSATIRN EMADLEELGFIEKTHSSSGRVPSEKGYRYYVDHLLSPVKLTKSDLDQIHSIFKEKIFE LEKTVQKSAQILSDLTNYTSIVLGPKLSENYLKQIQIIPIQPDMAVAILVTNTGHVEN KTINFPTKMDLSDIEKLVNILNDRLSGVPMDELNERIFKEVVMYLRQHIKNYDNILDA LRSTFHSTNHVEKLFFGGKINMLNQPEFHDITRVRSLLSLIEKEQDVLKLVQSPHTGI SIKIGKENDYEEMENCSLITASYSVDQKQIGSIAIIGPTRMNYSRVVSLLQHVTSDLS KALTSLYDE*" /label="hrcA CDS" gene complement(2324812..2325843) /gene="hrcA" /locus_tag="BSU_25490" /old_locus_tag="BSU25490" /label="hrcA gene" promotor_-10 complement(2325884..2325903) /Source="Nicolas_upshift_promotors" /id="U1983" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.629370629370629" /psig=1 /xcortree=2023 /SigmaFactorBS="tgaagtttttggcgcttttttgggtgagttatAATTGACAtt tttcttgtggttTGATACTTTTGTTATAGAATtagcactcgcttattgagagtgctaa c" /listShort="hrcA, S960, grpE, dnaK, S959, dnaJ, prmA, rsmE, rimO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2325897) /Source="Nicolas_upshifts" /id="U1983" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.629370629370629" /psig=1 /xcortree=2023 /SigmaFactorBS="tgaagtttttggcgcttttttgggtgagttatAATTGACAtt tttcttgtggttTGATACTTTTGTTATAGAATtagcactcgcttattgagagtgctaa c" /listShort="hrcA, S960, grpE, dnaK, S959, dnaJ, prmA, rsmE, rimO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2325918..2325925) /Source="Nicolas_upshift_promotors" /id="U1983" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.629370629370629" /psig=1 /xcortree=2023 /SigmaFactorBS="tgaagtttttggcgcttttttgggtgagttatAATTGACAtt tttcttgtggttTGATACTTTTGTTATAGAATtagcactcgcttattgagagtgctaa c" /listShort="hrcA, S960, grpE, dnaK, S959, dnaJ, prmA, rsmE, rimO" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2325924..2327063) /gene="hemN" /locus_tag="BSU_25500" /old_locus_tag="BSU25500" /EC_number="1.3.98.3" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8757728, 9371469, 10498703, 12196143, 19944166" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8757728, 9371469, 10498703, 12196143, 19944166; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="coproporphyrinogen III oxidase" /protein_id="NP_390428.2" /db_xref="EnsemblGenomes-Gn:BSU25500" /db_xref="EnsemblGenomes-Tr:CAB14492" /db_xref="GOA:P54304" /db_xref="InterPro:IPR004559" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR010723" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR034505" /db_xref="SubtiList:BG11395" /db_xref="UniProtKB/Swiss-Prot:P54304" /translation="MKSAYIHIPFCEHICHYCDFNKYFIQSQPVDEYLNALEQEMINT IAKTGQPDLKTIFIGGGTPTSLSEEQLKKLMDMINRVLKPSSDLSEFAVEANPDDLSA EKLKILKEAGVNRLSFGVQTFEDDLLEKIGRVHKQKDVFTSFERAREIGFENISLDLM FGLPGQTLKHLEHSINTALSLDAEHYSVYSLIVEPKTVFYNLMQKGRLHLPPQEQEAE MYEIVMSKMEAHGIHQYEISNFAKAGMESKHNLTYWSNEQYFGFGAGAHGYIGGTRTV NVGPVKHYIDLIAEKGFPYRDTHEVTTEEQIEEEMFLGLRKTAGVSKKRFAEKYGRSL DGLFPSVLKDLAEKGLIHNSESAVYLTHQGKLLGNEVFGAFLGEL*" /label="hemN CDS" gene complement(2325924..2327063) /gene="hemN" /locus_tag="BSU_25500" /old_locus_tag="BSU25500" /label="hemN gene" promotor_-10 complement(2326936..2326947) /Source="Nicolas_upshift_promotors" /id="U1984" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=802 /SigmaFactorBS="aaatattttattcaaagtcagccagtcgacgagTATTTAAac gcactcgaacaGGAAATGATAAAtacaatagcaaaaaccgggcagcctgatctcaaaa c" /GFF_Attribute="listShort" /listLong="hrcA, S960, grpE, dnaK, S959, dnaJ" /label="promotor_-10" upshifts complement(2326940) /Source="Nicolas_upshifts" /id="U1984" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=802 /SigmaFactorBS="aaatattttattcaaagtcagccagtcgacgagTATTTAAac gcactcgaacaGGAAATGATAAAtacaatagcaaaaaccgggcagcctgatctcaaaa c" /GFF_Attribute="listShort" /listLong="hrcA, S960, grpE, dnaK, S959, dnaJ" /label="upshifts" promotor_-35 complement(2326961..2326967) /Source="Nicolas_upshift_promotors" /id="U1984" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=802 /SigmaFactorBS="aaatattttattcaaagtcagccagtcgacgagTATTTAAac gcactcgaacaGGAAATGATAAAtacaatagcaaaaaccgggcagcctgatctcaaaa c" /GFF_Attribute="listShort" /listLong="hrcA, S960, grpE, dnaK, S959, dnaJ" /label="promotor_-35" CDS complement(2327116..2328954) /gene="lepA" /locus_tag="BSU_25510" /old_locus_tag="BSU25510" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12511492, 17110332, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribosomal elongation factor, GTPase" /protein_id="NP_390429.1" /db_xref="EnsemblGenomes-Gn:BSU25510" /db_xref="EnsemblGenomes-Tr:CAB14493" /db_xref="GOA:P37949" /db_xref="InterPro:IPR000640" /db_xref="InterPro:IPR000795" /db_xref="InterPro:IPR004161" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR006297" /db_xref="InterPro:IPR009000" /db_xref="InterPro:IPR013842" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031157" /db_xref="InterPro:IPR035647" /db_xref="InterPro:IPR035654" /db_xref="SubtiList:BG10441" /db_xref="UniProtKB/Swiss-Prot:P37949" /translation="MTDKEKRLERQSRIRNFSIIAHIDHGKSTLADRILEKTSAITQR EMKEQLLDSMDLERERGITIKLNSVQLKYKAKDGEEYIFHLIDTPGHVDFTYEVSRSL AACEGAILVVDAAQGIEAQTLANVYLALDNDLEILPVINKIDLPSAEPERVRQEVEDV IGLDASEAVLASAKAGIGIEEILEQIVEKVPAPTGDPEAPLKALIFDSLYDAYRGVVA YIRVVEGTVKPGQKIKMMATGKEFEVTEVGVFTPKATPTNELTVGDVGFLTASIKNVG DTRVGDTITSAANPAEEALPGYRKLNPMVYCGLYPIDTAKYNDLREALEKLELNDSSL QYEAETSQALGFGFRCGFLGMLHMEIIQERIEREFNIDLITTAPSVIYDVYMTDGEKV VVDNPSNMPDPQKIERVEEPYVKATMMVPNDYVGAVMELCQGKRGNFIDMQYLDANRV SIIYDMPLAEIVYEFFDQLKSSTKGYASFDYELIGYKPSKLVKMDIMLNGEKIDALSF IVHRDYAYERGKVIVEKLKELIPRQQFEVPVQAAIGQKIVARSTIKAMRKNVLAKCYG GDISRKRKLLEKQKEGKRRMKQVGSVEVPQEAFMAVLKMDDSPKKQ*" /label="lepA CDS" gene complement(2327116..2328954) /gene="lepA" /locus_tag="BSU_25510" /old_locus_tag="BSU25510" /label="lepA gene" downshifts complement(2327138) /Source="Nicolas_upshifts" /id="D1319" /incds=0 /nref=15 /ntot=213 /MaxReadThrough="5.2925" /MaxDrop="3.979" /score="5.45344919" /energy="-14" /TU="U1985" /idTUdmin="U1984" /TUdmin="-1232" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2328989..2329008) /Source="Nicolas_upshift_promotors" /id="U1985" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.701298701298701" /psig=1 /xcortree=2588 /SigmaFactorBS="cccagatatgatagggaacttttctctttcttgttttaCATT GaatctttacaatcctATTGATATAATCTAAGCTAGtgtattttgcgtttaatagtag g" /listShort="lepA, hemN, hrcA, S960, grpE, dnaK, S959, dnaJ, prmA, rsmE, rimO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2329006) /Source="Nicolas_upshifts" /id="U1985" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.701298701298701" /psig=1 /xcortree=2588 /SigmaFactorBS="cccagatatgatagggaacttttctctttcttgttttaCATT GaatctttacaatcctATTGATATAATCTAAGCTAGtgtattttgcgtttaatagtag g" /listShort="lepA, hemN, hrcA, S960, grpE, dnaK, S959, dnaJ, prmA, rsmE, rimO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2329024..2329028) /Source="Nicolas_upshift_promotors" /id="U1985" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.701298701298701" /psig=1 /xcortree=2588 /SigmaFactorBS="cccagatatgatagggaacttttctctttcttgttttaCATT GaatctttacaatcctATTGATATAATCTAAGCTAGtgtattttgcgtttaatagtag g" /listShort="lepA, hemN, hrcA, S960, grpE, dnaK, S959, dnaJ, prmA, rsmE, rimO" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2329088..2329426) /gene="yqxA" /locus_tag="BSU_25520" /old_locus_tag="BSU25520" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390430.1" /db_xref="EnsemblGenomes-Gn:BSU25520" /db_xref="EnsemblGenomes-Tr:CAB14494" /db_xref="InterPro:IPR020534" /db_xref="SubtiList:BG10440" /db_xref="UniProtKB/Swiss-Prot:P38425" /translation="MIAYFGKCLLLVTIMFLGVLFGMQQANHGMLSMKGYHDPSLKGA FTLTDGKDNEKEASILGETVTAKDLVEKQKELEKVETFNMFSKAGKALSDTVTNTAQS MYEWIRDMNQ*" /label="yqxA CDS" gene complement(2329088..2329426) /gene="yqxA" /locus_tag="BSU_25520" /old_locus_tag="BSU25520" /label="yqxA gene" downshifts complement(2329094) /Source="Nicolas_upshifts" /id="D1320" /incds=0 /nref=11 /ntot=43 /MaxReadThrough="2.553" /MaxDrop="3.8126" /score="5.45344919" /energy="-14" /TU="NA" /idTUdmin="U1986" /TUdmin=2 /isTUend="TRUE" /label="downshifts" CDS complement(2329443..2330648) /gene="spoIIP" /locus_tag="BSU_25530" /old_locus_tag="BSU25530" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:17376078, 23834622" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17376078, 23834622; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore autolysin (stage II sporulation)" /protein_id="NP_390431.1" /db_xref="EnsemblGenomes-Gn:BSU25530" /db_xref="EnsemblGenomes-Tr:CAB14495" /db_xref="GOA:P37968" /db_xref="InterPro:IPR010897" /db_xref="SubtiList:BG10439" /db_xref="UniProtKB/Swiss-Prot:P37968" /translation="MRNKRRNRQIVVAVNGGKAVKAIFLFIVSLIVIFVLSGVLTSLR PELRPSSDSFYGIAEELPGDVFAHLLQMENHYFASDLSQTDSSFHLSRLSLKLATSIN LEDPRSFLGRELPGFAQFDTEILLAGQGTDYTNMPAESPPPSKVMEEEREANLAEIEK QQTQSDNAQKDPPKQTTGDKKVVFIYHTHNTESYLPLLKGETDPDMARHSKANVTLVG DMFGQALESQGIGATVNKTDIQSKLNKKGLNYARSYDESRPVVKDALASNKNLQYIID IHRDSRRKKDTTATIKGKSYARVAFVVGKKSKNFEENYKIASELHKLMEKKYPGLSTG VFSKGSPGDNGVYNQDLTDRALLLEFGGVDNNLEELQRAANAAADVFSEMYWDAEKVN AASGETKKQ*" /label="spoIIP CDS" gene complement(2329443..2330648) /gene="spoIIP" /locus_tag="BSU_25530" /old_locus_tag="BSU25530" /label="spoIIP gene" promotor_-10 complement(2330668..2330686) /Source="Nicolas_upshift_promotors" /id="U1986" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.58941058941059" /psig="0.58941058941059" /xcortree=451 /SigmaFactorBS="caagaaaacaaaggctcctacaatcactaaacaGTTCTActt cctctagcttgtTCATAGAGTAATTACTAGAcaagcgctggagggattcaatgagaaa t" /listShort="spoIIP, yqxA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2330680) /Source="Nicolas_upshifts" /id="U1986" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.58941058941059" /psig="0.58941058941059" /xcortree=451 /SigmaFactorBS="caagaaaacaaaggctcctacaatcactaaacaGTTCTActt cctctagcttgtTCATAGAGTAATTACTAGAcaagcgctggagggattcaatgagaaa t" /listShort="spoIIP, yqxA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2330702..2330707) /Source="Nicolas_upshift_promotors" /id="U1986" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.58941058941059" /psig="0.58941058941059" /xcortree=451 /SigmaFactorBS="caagaaaacaaaggctcctacaatcactaaacaGTTCTActt cctctagcttgtTCATAGAGTAATTACTAGAcaagcgctggagggattcaatgagaaa t" /listShort="spoIIP, yqxA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2330711..2331817) /gene="gpr" /locus_tag="BSU_25540" /old_locus_tag="BSU25540" /EC_number="3.4.24.78" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10666631, 10986255, 12807468, 23927687" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10666631, 10986255, 12807468, 23927687; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore germination protease" /protein_id="NP_390432.1" /db_xref="EnsemblGenomes-Gn:BSU25540" /db_xref="EnsemblGenomes-Tr:CAB14496" /db_xref="GOA:P22322" /db_xref="InterPro:IPR005080" /db_xref="InterPro:IPR023430" /db_xref="SubtiList:BG10438" /db_xref="UniProtKB/Swiss-Prot:P22322" /translation="MKKSELDVNQYLIRTDLAVETKEAMANQQAVPTKEIKGFIEKER DHGGIKIRTVDVTKEGAELSGKKEGRYLTLEAQGIRENDSEMQEKVSAVFAEEFSAFL ENLNISKDASCLIVGLGNWNVTPDALGPMAVENLLVTRHLFKLQPENVQEGYRPVSAF APGVMGITGIETSDIIKGVIEQSKPDFVIAIDALAARAVERVNTTIQISDTGIHPGSG VGNKRKDLSKDTLGVPVIAIGVPTVVDAVTIASDTVDYILKHFGREMKDNRPSRSLVP AGMTFGKKKVLTEDDLPDQKQRQSFLGIVGTLQEDEKRQLIHEVLSPLGHNLMVTPKE VDSFIDDMANVLANGLNTALHEKVSQENKGSYNH*" /label="gpr CDS" gene complement(2330711..2331817) /gene="gpr" /locus_tag="BSU_25540" /old_locus_tag="BSU25540" /label="gpr gene" promotor_-10 complement(2331845..2331856) /Source="Nicolas_upshift_promotors" /id="U1987" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1139 /SigmaFactorBS="aatgtaaagtatttttcattgaaggttctctttttAGCATGA tttattcagcaaatGGCAACAATATAggtacttaatgtgaaggaggcccctgtatgaa a" /listShort="gpr, spoIIP, yqxA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2331852) /Source="Nicolas_upshifts" /id="U1987" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1139 /SigmaFactorBS="aatgtaaagtatttttcattgaaggttctctttttAGCATGA tttattcagcaaatGGCAACAATATAggtacttaatgtgaaggaggcccctgtatgaa a" /listShort="gpr, spoIIP, yqxA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2331871..2331877) /Source="Nicolas_upshift_promotors" /id="U1987" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1139 /SigmaFactorBS="aatgtaaagtatttttcattgaaggttctctttttAGCATGA tttattcagcaaatGGCAACAATATAggtacttaatgtgaaggaggcccctgtatgaa a" /listShort="gpr, spoIIP, yqxA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2331916..2331919 /Source="Nicolas_upshift_promotors" /id="U1988" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.63936063936064" /psig=1 /xcortree=2636 /SigmaFactorBS="catgctaaaaagagaaccttcaatgaaaaatactttacattt atATTGcaatctaaaggtgtgTTTGATAGAATACAATTTGTtctattgtgaagaagat t" /listShort="S961, rpsT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2331932 /Source="Nicolas_upshifts" /id="U1988" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.63936063936064" /psig=1 /xcortree=2636 /SigmaFactorBS="catgctaaaaagagaaccttcaatgaaaaatactttacattt atATTGcaatctaaaggtgtgTTTGATAGAATACAATTTGTtctattgtgaagaagat t" /listShort="S961, rpsT" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2331935..2331954 /Source="Nicolas_upshift_promotors" /id="U1988" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.63936063936064" /psig=1 /xcortree=2636 /SigmaFactorBS="catgctaaaaagagaaccttcaatgaaaaatactttacattt atATTGcaatctaaaggtgtgTTTGATAGAATACAATTTGTtctattgtgaagaagat t" /listShort="S961, rpsT" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2331946..2332020 /Source="Nicolas_S_feature" /locus_tag="new_2635740_2635814" /HighExp="HiTm, LPhT, UNK1, HiOs, dia5, aero, MG 15, SMM, Lbtran, MG 45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S961" CDS 2332021..2332287 /gene="rpsT" /locus_tag="BSU_25550" /old_locus_tag="BSU25550" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 16629673, 23002217" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16629673, 23002217; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S20 (BS20)" /protein_id="NP_390433.2" /db_xref="EnsemblGenomes-Gn:BSU25550" /db_xref="EnsemblGenomes-Tr:CAB14497" /db_xref="GOA:P21477" /db_xref="InterPro:IPR002583" /db_xref="InterPro:IPR036510" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11643" /db_xref="UniProtKB/Swiss-Prot:P21477" /translation="MPNIKSAIKRTKTNNERRVHNATIKSAMRTAIKQVEASVANNEA DKAKTALTEAAKRIDKAVKTGLVHKNTAARYKSRLAKKVNGLSA*" /label="rpsT CDS" gene 2332021..2332287 /gene="rpsT" /locus_tag="BSU_25550" /old_locus_tag="BSU25550" /label="rpsT gene" downshifts 2332276 /Source="Nicolas_upshifts" /id="D1321" /incds=0 /nref=244 /ntot=274 /MaxReadThrough="2.22204" /MaxDrop="8.54705" /score="33.3621187" /energy="-12.3" /TU="NA" /idTUdmin="U1988" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2332302..2333345) /gene="holA" /locus_tag="BSU_25560" /old_locus_tag="BSU25560" /EC_number="2.7.7.7" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:9434186, 11432857, 12060778, 12682299, 22333191, 23525462" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9434186, 11432857, 12060778, 12682299, 22333191, 23525462; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="DNA polymerase clamp loader delta subunit" /protein_id="NP_390434.1" /db_xref="EnsemblGenomes-Gn:BSU25560" /db_xref="EnsemblGenomes-Tr:CAB14498" /db_xref="GOA:P54459" /db_xref="InterPro:IPR005790" /db_xref="InterPro:IPR008921" /db_xref="InterPro:IPR010372" /db_xref="InterPro:IPR027417" /db_xref="PDB:3ZH9" /db_xref="SubtiList:BG11642" /db_xref="UniProtKB/Swiss-Prot:P54459" /translation="MVFDVWKSLKKGEVHPVYCLYGKETYLLQETVSRIRQTVVDQET KDFNLSVFDLEEDPLDQAIADAETFPFMGERRLVIVKNPYFLTGEKKKEKIEHNVSAL ESYIQSPAPYTVFVLLAPYEKLDERKKLTKALKKHAFMMEAKELNAKETTDFTVNLAK TEQKTIGTEAAEHLVLLVNGHLSSIFQEIQKLCTFIGDREEITLDDVKMLVARSLEQN IFELINKIVNRKRTESLQIFYDLLKQNEEPIKIMALISNQFRLILQTKYFAEQGYGQK QIASNLKVHPFRVKLAMDQARLFSEEELRLIIEQLAVMDYEMKTGKKDKQLLLELFLL QLLKRNEKNDPHY*" /label="holA CDS" gene complement(2332302..2333345) /gene="holA" /locus_tag="BSU_25560" /old_locus_tag="BSU25560" /label="holA gene" downshifts complement(2332347) /Source="Nicolas_upshifts" /id="D1322" /incds=0 /nref=14 /ntot=198 /MaxReadThrough="1.76478" /MaxDrop="4.34213" /score="-1.12561483" /energy="-8.1" /TU="NA" /idTUdmin="U1989" /TUdmin=5 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2333374..2333393) /Source="Nicolas_upshift_promotors" /id="U1989" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.519480519480519" /psig="0.953046953046953" /xcortree=2159 /SigmaFactorBS="ttaatataaatggggaagcagcagtcaggcttcctCTTTAct attttgcaaacTCAATTTAGGATAGAAGGGGatgatgaaagagaggaagtcgtacaac a" /listShort="holA" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2333385..2333534) /locus_tag="BSU_25565" /old_locus_tag="BSU25565" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513978.1" /translation="MKNLEAKVTFSVLVIIAFLQAVPGACEQAFNINGEAAVRLPLYY FANSI*" /label="hypothetical protein CDS" gene complement(2333385..2333534) /locus_tag="BSU_25565" /old_locus_tag="BSU25565" /label="gene" upshifts complement(2333386) /Source="Nicolas_upshifts" /id="U1989" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.519480519480519" /psig="0.953046953046953" /xcortree=2159 /SigmaFactorBS="ttaatataaatggggaagcagcagtcaggcttcctCTTTAct attttgcaaacTCAATTTAGGATAGAAGGGGatgatgaaagagaggaagtcgtacaac a" /listShort="holA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2333407..2333411) /Source="Nicolas_upshift_promotors" /id="U1989" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.519480519480519" /psig="0.953046953046953" /xcortree=2159 /SigmaFactorBS="ttaatataaatggggaagcagcagtcaggcttcctCTTTAct attttgcaaacTCAATTTAGGATAGAAGGGGatgatgaaagagaggaagtcgtacaac a" /listShort="holA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2333409..2333748) /Source="Nicolas_S_feature" /locus_tag="new_2637203_2637542_c" /HighExp="S8, S6, S7, BT, S5, C30, Pyr, G/S, B36, GM 150" /AntisenseName="yqzM" /AntisenseCor="-2.0369593011890001E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA" /TUshortPSig="1, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S962" downshifts complement(2333452) /Source="Nicolas_upshifts" /id="D1323" /incds=0 /nref=4 /ntot=37 /MaxReadThrough="5.04584" /MaxDrop="3.298" /score="-1.12561483" /energy="-8.1" /TU="U1991,U1995" /idTUdmin="U1992" /TUdmin=748 /isTUend="FALSE" /label="downshifts" promotor_-35 2333521..2333527 /Source="Nicolas_upshift_promotors" /id="U1990" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.405594405594406" /psig=1 /xcortree=421 /SigmaFactorBS="aaggcgataatcaccagaacagaaaacgttaccttagctTCT AGATttttcaaaacaatTCCATTATACTTAAGTCAGTcaggagggataaagttgaatg a" /listShort="yqzM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2333541..2333560 /Source="Nicolas_upshift_promotors" /id="U1990" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.405594405594406" /psig=1 /xcortree=421 /SigmaFactorBS="aaggcgataatcaccagaacagaaaacgttaccttagctTCT AGATttttcaaaacaatTCCATTATACTTAAGTCAGTcaggagggataaagttgaatg a" /listShort="yqzM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2333542 /Source="Nicolas_upshifts" /id="U1990" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.405594405594406" /psig=1 /xcortree=421 /SigmaFactorBS="aaggcgataatcaccagaacagaaaacgttaccttagctTCT AGATttttcaaaacaatTCCATTATACTTAAGTCAGTcaggagggataaagttgaatg a" /listShort="yqzM" /GFF_Attribute="listLong" /label="upshifts" CDS 2333575..2333709 /gene="yqzM" /locus_tag="BSU_25569" /old_locus_tag="BSU25569" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097762.1" /db_xref="EnsemblGenomes-Gn:BSU25569" /db_xref="EnsemblGenomes-Tr:CAX52662" /db_xref="GOA:C0H453" /db_xref="InterPro:IPR025416" /db_xref="UniProtKB/Swiss-Prot:C0H453" /translation="MNDFEKNVQSKRNDAVDSAVGFVVSFGFFAFLFVMATVIHLVGS *" /label="yqzM CDS" gene 2333575..2333709 /gene="yqzM" /locus_tag="BSU_25569" /old_locus_tag="BSU25569" /label="yqzM gene" downshifts 2333703 /Source="Nicolas_upshifts" /id="D1324" /incds=0 /nref=156 /ntot=250 /MaxReadThrough="3.51266" /MaxDrop="6.2258" /score="20.1810918" /energy="-12.1" /TU="U1990" /idTUdmin="U1990" /TUdmin="-465" /isTUend="FALSE" /label="downshifts" CDS complement(2333749..2336079) /gene="comEC" /locus_tag="BSU_25570" /old_locus_tag="BSU25570" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:12123453, 15661011, 16751195, 17630974, 21397556, 27318187" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12123453, 15661011, 16751195, 17630974, 21397556, 27318187; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="DNA channel for uptake in competent cells" /protein_id="NP_390435.1" /db_xref="EnsemblGenomes-Gn:BSU25570" /db_xref="EnsemblGenomes-Tr:CAB14499" /db_xref="GOA:P39695" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR004477" /db_xref="InterPro:IPR004797" /db_xref="InterPro:IPR025405" /db_xref="InterPro:IPR035681" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG10482" /db_xref="UniProtKB/Swiss-Prot:P39695" /translation="MRNSRLLLPMAAASATAGITAAAYFPAIFLFILFLLIILIKTRH AFLIIVCFFSFILFFVLYAVTDSQNVSSYRQGTYQFKAVIDTIPKIDGDRMSMMVETP DKEKWAAAYRIQSAGEKEQLLYIEPGMSCELTGTLEEPNHATVPGAFDYNEYLYRQHI HWNYSVTSIQNCSEPENFKYKVLSLRKHIISFTNSLLPPDSTGIVQALTVGDRFYVED EVLTAYQKLGVVHLLAISGLHVGILTAGLFYIMIRLGITREKASILLLLFLPLYVMLT GAAPSVLRAALMSGVYLAGSLVKWRVRSATAICLSYIVLLLFNPYHLFEAGFQLSFAV SFSLILSSSIFQQVKTSLGQLTIVSLIAQLGSLPILLYHFHQFSIISVPMNMLMVPFY TFCILPGAVAGVLLLSLSASFGRLFFSWFDLLISWINRLITNIADVDVFTIMIAHPAP VLLFLFTVTIILLLMAIEKRSLSQLMVTGGICCTVMFLLFIYPCLSSEGEVDMIDIGQ GDSMFVGAPHQRGRVLIDTGGTLSYSSEPWREKQHPFSLGEKVLIPFLTAKGIKQLDA LILTHADQDHIGEAEILLKHHKVKRLVIPKGFVSEPKDEKVLQAAREEGVAIEEVKRG DVLQIKDLQFHVLSPEAPDPASKNNSSLVLWMETGGMSWILTGDLEKEGEQEVMNVFP NIKADVLKVGHHGSKGSTGEEFIQQLQPKTAIISAGKNNRYHHPHQKVLQLLQRHSIR VLRTDQNGTIQYRYKNRVGTFSVYPPYDTSDITETN*" /label="comEC CDS" gene complement(2333749..2336079) /gene="comEC" /locus_tag="BSU_25570" /old_locus_tag="BSU25570" /label="comEC gene" promotor_-10 complement(2333766..2333785) /Source="Nicolas_upshift_promotors" /id="U1991" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1328 /SigmaFactorBS="aaacggaacgatccaatatagatacaaaaacagaGTTGGAAC CTtttctgtctatccTCCATATGATACATCAGATAtaacagagacgaactaaaaaaga c" /listShort="S962, holA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2333782) /Source="Nicolas_upshifts" /id="U1991" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1328 /SigmaFactorBS="aaacggaacgatccaatatagatacaaaaacagaGTTGGAAC CTtttctgtctatccTCCATATGATACATCAGATAtaacagagacgaactaaaaaaga c" /listShort="S962, holA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2333799..2333808) /Source="Nicolas_upshift_promotors" /id="U1991" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1328 /SigmaFactorBS="aaacggaacgatccaatatagatacaaaaacagaGTTGGAAC CTtttctgtctatccTCCATATGATACATCAGATAtaacagagacgaactaaaaaaga c" /listShort="S962, holA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2336083..2336652) /gene="comEB" /locus_tag="BSU_25580" /old_locus_tag="BSU25580" /EC_number="3.5.4.12" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 7768800, 26416910; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="dCMP deaminase associated to DNA transport (competence)" /protein_id="NP_390436.1" /db_xref="EnsemblGenomes-Gn:BSU25580" /db_xref="EnsemblGenomes-Tr:CAB14500" /db_xref="GOA:P32393" /db_xref="InterPro:IPR002125" /db_xref="InterPro:IPR013404" /db_xref="InterPro:IPR015517" /db_xref="InterPro:IPR016192" /db_xref="InterPro:IPR016193" /db_xref="InterPro:IPR016473" /db_xref="InterPro:IPR035105" /db_xref="SubtiList:BG10481" /db_xref="UniProtKB/Swiss-Prot:P32393" /translation="MERISWNQYFMAQSHLLALRSTCPRLSVGATIVRDKRMIAGGYN GSIAGGVHCADEGCLMIDDHCARTIHAEMNAILQCSKFGVPTDGAEIYVTHYPCIQCC KSIIQAGIKTVYYAEDYKTHPYAQELFEQAGVTVEQVELDEMIVDLKNREKLSFVAGL IGKLADAGLAEEELKKIHEQANTLFTSYV*" /label="comEB CDS" gene complement(2336083..2336652) /gene="comEB" /locus_tag="BSU_25580" /old_locus_tag="BSU25580" /label="comEB gene" promotor_-10 complement(2336679..2336698) /Source="Nicolas_upshift_promotors" /id="U1992" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=1881 /SigmaFactorBS="gaaaataaagtcttccattacagtaaagtGATTTGACggtca tgcattatgATAGGTAAACTAAAGGTCAGgcaacacaacatttggagggaacaacgtg g" /listShort="comEB, comEC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2336689) /Source="Nicolas_upshifts" /id="U1992" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=1881 /SigmaFactorBS="gaaaataaagtcttccattacagtaaagtGATTTGACggtca tgcattatgATAGGTAAACTAAAGGTCAGgcaacacaacatttggagggaacaacgtg g" /listShort="comEB, comEC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2336713..2336720) /Source="Nicolas_upshift_promotors" /id="U1992" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=1881 /SigmaFactorBS="gaaaataaagtcttccattacagtaaagtGATTTGACggtca tgcattatgATAGGTAAACTAAAGGTCAGgcaacacaacatttggagggaacaacgtg g" /listShort="comEB, comEC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2336719..2337336) /gene="comEA" /locus_tag="BSU_25590" /old_locus_tag="BSU25590" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16751195, 21278288, 22398145, 25727469" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16751195, 21278288, 22398145, 25727469; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="membrane bound high-affinity DNA-binding receptor" /protein_id="NP_390437.1" /db_xref="EnsemblGenomes-Gn:BSU25590" /db_xref="EnsemblGenomes-Tr:CAB14501" /db_xref="GOA:P39694" /db_xref="InterPro:IPR003583" /db_xref="InterPro:IPR004509" /db_xref="InterPro:IPR004787" /db_xref="InterPro:IPR010994" /db_xref="InterPro:IPR019554" /db_xref="SubtiList:BG10480" /db_xref="UniProtKB/Swiss-Prot:P39694" /translation="MNWLNQHKKAIILAASAAVFTAIMIFLATGKNKEPVKQAVPTET ENTVVKQEANNDESNETIVIDIKGAVQHPGVYEMRTGDRVSQAIEKAGGTSEQADEAQ VNLAEILQDGTVVYIPKKGEETAVQQGGGGSVQSDGGKGALVNINTATLEELQGISGV GPSKAEAIIAYREENGRFQTIEDITKVSGIGEKSFEKIKSSITVK*" /label="comEA CDS" gene complement(2336719..2337336) /gene="comEA" /locus_tag="BSU_25590" /old_locus_tag="BSU25590" /label="comEA gene" promotor_-35 2337357..2337362 /Source="Nicolas_upshift_promotors" /id="U1993" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1103 /SigmaFactorBS="ttatgctgattcaaccaattcatcgtgcatgttccccgcttt cGTCATAttttattttcataacACATATGGTTTAGAGGATAatagctcaaaggagggg a" /listShort="comER" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2337374 /Source="Nicolas_upshifts" /id="U1993" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1103 /SigmaFactorBS="ttatgctgattcaaccaattcatcgtgcatgttccccgcttt cGTCATAttttattttcataacACATATGGTTTAGAGGATAatagctcaaaggagggg a" /listShort="comER" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2337378..2337396 /Source="Nicolas_upshift_promotors" /id="U1993" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1103 /SigmaFactorBS="ttatgctgattcaaccaattcatcgtgcatgttccccgcttt cGTCATAttttattttcataacACATATGGTTTAGAGGATAatagctcaaaggagggg a" /listShort="comER" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2337397..2337411) /Source="Nicolas_upshift_promotors" /id="U1994" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=681 /SigmaFactorBS="tcgtacccatatttcctgtgccgataaagcctatcTTCAAtg gtttccCCTCCTTTGAGCTATtatcctctaaaccatatgtgttatgaaaataaaatat g" /listShort="comEA, comEB, comEC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2337399) /Source="Nicolas_upshifts" /id="U1994" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=681 /SigmaFactorBS="tcgtacccatatttcctgtgccgataaagcctatcTTCAAtg gtttccCCTCCTTTGAGCTATtatcctctaaaccatatgtgttatgaaaataaaatat g" /listShort="comEA, comEB, comEC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2337401..2338248) /Source="Nicolas_S_feature" /locus_tag="new_2641195_2642042_c" /HighExp="C30, T0.30H, T-2.40H, GM 150, T1.30H, T-0.40H, T-1.10H, T-1.40H, T1.0H, T0.0H" /AntisenseName="comER" /AntisenseCor="-8.2389039371154299E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S963" promotor_-35 complement(2337420..2337424) /Source="Nicolas_upshift_promotors" /id="U1994" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=681 /SigmaFactorBS="tcgtacccatatttcctgtgccgataaagcctatcTTCAAtg gtttccCCTCCTTTGAGCTATtatcctctaaaccatatgtgttatgaaaataaaatat g" /listShort="comEA, comEB, comEC" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2337420..2338241 /gene="comER" /locus_tag="BSU_25600" /old_locus_tag="BSU25600" /EC_number="1.5.1.2" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7968523, 11418582, 27446060, 28824574; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative pyrroline-5'-carboxylate reductase" /protein_id="NP_390438.1" /db_xref="EnsemblGenomes-Gn:BSU25600" /db_xref="EnsemblGenomes-Tr:CAB14502" /db_xref="GOA:P39696" /db_xref="InterPro:IPR000304" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR028939" /db_xref="InterPro:IPR029036" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10479" /db_xref="UniProtKB/Swiss-Prot:P39696" /translation="MKIGFIGTGNMGTILIESFIESKAADPSNMTITNRTIEKALHIK NRYNSINVTESLEKLVSENEMIFICVKPLDIYPLLARALPYLRKDHILISITSPVQTE QLEQYVPCQVARVIPSITNRALAGVSLVTFGTSCGESAKAKINELMQHISHPLQIESD ITRVASDIVSCGPAFMSYLIQRFIDAAVSETSVSKQDAILMCKEMLVGMGKLLETELY TLPALQEKVCVKGGVTGEGIKALESGVQDMFHRVFQNTHMKYEEDISAVKKQFHV*" /label="comER CDS" gene 2337420..2338241 /gene="comER" /locus_tag="BSU_25600" /old_locus_tag="BSU25600" /label="comER gene" promotor_-10 complement(2338236..2338255) /Source="Nicolas_upshift_promotors" /id="U1995" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.95104895104895" /psig="0.996003996003996" /xcortree=2968 /SigmaFactorBS="taaaacgatggttttttaaaatgcttttttatgCTTTTGCAg tacagacgaacgTATGACATACTCGTCTACACatgaaactgctttttcactgcggaaa t" /listShort="S963, comEA, comEB, comEC, S962, holA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2338242..2338322 /Source="Nicolas_S_feature" /locus_tag="new_2642036_2642116" /HighExp="S4, S5, S3, S6, S7, B36, Pyr, G/S, S8, BT" /AntisenseName="yqeM" /AntisenseCor="-0.52267300854840604" /AntisenseRegPval="-19.5" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S964" upshifts complement(2338249) /Source="Nicolas_upshifts" /id="U1995" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.95104895104895" /psig="0.996003996003996" /xcortree=2968 /SigmaFactorBS="taaaacgatggttttttaaaatgcttttttatgCTTTTGCAg tacagacgaacgTATGACATACTCGTCTACACatgaaactgctttttcactgcggaaa t" /listShort="S963, comEA, comEB, comEC, S962, holA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2338269..2338276) /Source="Nicolas_upshift_promotors" /id="U1995" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.95104895104895" /psig="0.996003996003996" /xcortree=2968 /SigmaFactorBS="taaaacgatggttttttaaaatgcttttttatgCTTTTGCAg tacagacgaacgTATGACATACTCGTCTACACatgaaactgctttttcactgcggaaa t" /listShort="S963, comEA, comEB, comEC, S962, holA" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2338282 /Source="Nicolas_upshifts" /id="D1325" /incds=0 /nref=45 /ntot=64 /MaxReadThrough="2.4803" /MaxDrop="5.1403" /score="7.09525061" /energy="-10.5" /TU="NA" /idTUdmin="U1993" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2338307..2339050) /gene="yqeM" /locus_tag="BSU_25610" /old_locus_tag="BSU25610" /EC_number="2.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative methyltransferase" /protein_id="NP_390439.1" /db_xref="EnsemblGenomes-Gn:BSU25610" /db_xref="EnsemblGenomes-Tr:CAB14503" /db_xref="GOA:P54458" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11641" /db_xref="UniProtKB/Swiss-Prot:P54458" /translation="MIYQGFASVYDELMSHAPYDQWTKWIEASLPEKGRILDLACGTG EISIRLAEKGFEVTGIDLSEEMLSFAQQKVSSSQPILFLQQDMREITGFDGQFDAVVI CCDSLNYLKTKNDVIETFKSVFRVLKPEGILLFDVHSSFKIAEVFPDSTFADQDEDIS YIWQSFAGSDELSVIHDMSFFVWNGEAYDRFDETHEQRTFPVEEYEEMLKNCGFQLHR VTADFTDTEPSAQSERLFFKAQKSKTIVS*" /label="yqeM CDS" gene complement(2338307..2339050) /gene="yqeM" /locus_tag="BSU_25610" /old_locus_tag="BSU25610" /label="yqeM gene" downshifts complement(2338337) /Source="Nicolas_upshifts" /id="D1326" /incds=0 /nref=144 /ntot=230 /MaxReadThrough="1.41467" /MaxDrop="5.51802" /score="7.9251293" /energy="-10.5" /TU="NA" /idTUdmin="U1996" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2339047..2339403) /gene="rsfS" /locus_tag="BSU_25620" /old_locus_tag="BSU25620" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15044829, 16980477, 22238375, 22238376, 22829778, 26299947; Product type f : factor" /codon_start=1 /transl_table=11 /product="ribosomal silencing factor" /protein_id="NP_390440.1" /db_xref="EnsemblGenomes-Gn:BSU25620" /db_xref="EnsemblGenomes-Tr:CAB14504" /db_xref="GOA:P54457" /db_xref="InterPro:IPR004394" /db_xref="SubtiList:BG11640" /db_xref="UniProtKB/Swiss-Prot:P54457" /translation="MNQKSILKIAAAACDDKRAEDILALDMEGISLVADYFLICHGNS DKQVQAIAREIKDQADENGIQVKKMEGFDEARWVLVDLGDVVVHVFHKDERSYYNLEK LWGDAPLADLDFGMNQ*" /label="rsfS CDS" gene complement(2339047..2339403) /gene="rsfS" /locus_tag="BSU_25620" /old_locus_tag="BSU25620" /label="rsfS gene" CDS complement(2339421..2339981) /gene="yqeK" /locus_tag="BSU_25630" /old_locus_tag="BSU25630" /function="16.2: Construct biomass (Anabolism)" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15175311, 22333191; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_390441.1" /db_xref="EnsemblGenomes-Gn:BSU25630" /db_xref="EnsemblGenomes-Tr:CAB14505" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR005249" /db_xref="InterPro:IPR006674" /db_xref="SubtiList:BG11639" /db_xref="UniProtKB/Swiss-Prot:P54456" /translation="MNREEALACVKQQLTEHRYIHTVGVMNTAIELAERFGADSKKAE IAAIFHDYAKFRPKEEMKQIIAREKMPAHLLDHNPELWHAPVGAYLVQREAGVQDEDI LDAIRYHTSGRPGMTLLEKVIYVADYIEPNRAFPGVDEVRKLAETDLNQALIQSIKNT MVFLMKKNQPVFPDTFLTYNWLVSGS*" /label="yqeK CDS" gene complement(2339421..2339981) /gene="yqeK" /locus_tag="BSU_25630" /old_locus_tag="BSU25630" /label="yqeK gene" CDS complement(2339971..2340540) /gene="nadD" /locus_tag="BSU_25640" /old_locus_tag="BSU25640" /EC_number="2.7.7.18" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11704676, 12682299, 19716475, 23204464, 25631047; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nicotinate-nucleotide adenylyltransferase" /protein_id="NP_390442.1" /db_xref="EnsemblGenomes-Gn:BSU25640" /db_xref="EnsemblGenomes-Tr:CAB14506" /db_xref="GOA:P54455" /db_xref="InterPro:IPR004821" /db_xref="InterPro:IPR005248" /db_xref="InterPro:IPR014729" /db_xref="PDB:1KAM" /db_xref="PDB:1KAQ" /db_xref="SubtiList:BG11638" /db_xref="UniProtKB/Swiss-Prot:P54455" /translation="MKKIGIFGGTFDPPHNGHLLMANEVLYQAGLDEIWFMPNQIPPH KQNEDYTDSFHRVEMLKLAIQSNPSFKLELVEMEREGPSYTFDTVSLLKQRYPNDQLF FIIGADMIEYLPKWYKLDELLNLIQFIGVKRPGFHVETPYPLLFADVPEFEVSSTMIR ERFKSKKPTDYLIPDKVKKYVEENGLYES*" /label="nadD CDS" gene complement(2339971..2340540) /gene="nadD" /locus_tag="BSU_25640" /old_locus_tag="BSU25640" /label="nadD gene" CDS complement(2340552..2340842) /gene="yqeI" /locus_tag="BSU_25650" /old_locus_tag="BSU25650" /experiment="publication(s) with functional evidences, PMID:12682299, 16014871, 17005971, 17105995" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16014871, 17005971, 17105995; Product type f: factor" /codon_start=1 /transl_table=11 /product="50S RNA-binding protein" /protein_id="NP_390443.1" /db_xref="EnsemblGenomes-Gn:BSU25650" /db_xref="EnsemblGenomes-Tr:CAB14507" /db_xref="GOA:P54454" /db_xref="InterPro:IPR001890" /db_xref="InterPro:IPR017924" /db_xref="InterPro:IPR035920" /db_xref="SubtiList:BG11637" /db_xref="UniProtKB/Swiss-Prot:P54454" /translation="MLTGKQKRFLRSKAHHLTPIFQVGKGGVNDNMIKQIAEALEARE LIKVSVLQNCEEDKNDVAEALVKGSRSQLVQTIGNTIVLYKESKENKQIELP*" /label="yqeI CDS" gene complement(2340552..2340842) /gene="yqeI" /locus_tag="BSU_25650" /old_locus_tag="BSU25650" /label="yqeI gene" CDS complement(2340836..2341678) /gene="aroE" /locus_tag="BSU_25660" /old_locus_tag="BSU25660" /EC_number="1.1.1.25" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2104604, 12906820, 22938038; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="shikimate 5-dehydrogenase" /protein_id="NP_390444.2" /db_xref="EnsemblGenomes-Gn:BSU25660" /db_xref="EnsemblGenomes-Tr:CAB14508" /db_xref="GOA:P54374" /db_xref="InterPro:IPR006151" /db_xref="InterPro:IPR011342" /db_xref="InterPro:IPR013708" /db_xref="InterPro:IPR022893" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11522" /db_xref="UniProtKB/Swiss-Prot:P54374" /translation="MKKLYGVIGNPIGHSMSPDIHNASLKDLGLDGHYHAFKVEENDL EDAVKGIRALGVQGINVTVPHKVSIMDYLDHIDESAKVLGAVNTVRREGDKLVGYNTD GEGFVKSLMKVLDKPISELSFLMIGAGGAARAIFTTIVRNTPKKFDICNRTLEKAKRL TEATPSFHNKEVLSIKEAEERLEQYDVIIHTTSVGMYPNVDDVPLSLQRAASSAVVCD IVYNPIQTALLKEASQKGLKTLDGVGMFVEQAALSFQLWTGQEPNIEKMRSIVIGKLG GTEC*" /label="aroE CDS" gene complement(2340836..2341678) /gene="aroE" /locus_tag="BSU_25660" /old_locus_tag="BSU25660" /label="aroE gene" downshifts 2341670 /Source="Nicolas_upshifts" /id="D1327" /incds=0 /nref=2 /ntot=118 /MaxReadThrough="0.240279999999999" /MaxDrop="3.04009" /score="0.0642154872" /energy="-17" /TU="NA" /idTUdmin="U1993" /TUdmin=3388 /isTUend="FALSE" /label="downshifts" CDS complement(2341696..2342796) /gene="rgpH" /locus_tag="BSU_25670" /old_locus_tag="BSU25670" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12427945, 12682299, 17237168, 17895579, 18801747, 19540197, 20376346, 22750478" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12427945, 12682299, 17237168, 17895579, 18801747, 19540197, 20376346, 22750478; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="potassium-dependent GTPase involved in ribosome 30S assembly" /protein_id="NP_390445.1" /db_xref="EnsemblGenomes-Gn:BSU25670" /db_xref="EnsemblGenomes-Tr:CAB14509" /db_xref="GOA:P54453" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR019988" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030378" /db_xref="SubtiList:BG11636" /db_xref="UniProtKB/Swiss-Prot:P54453" /translation="MEKVVCIGCGVTIQTEDKTGLGYAPPASLTKENVICQRCFRLKN YNEIQDVSLTDDDFLNILHGIGETDSLVVKIVDIFDFNGSWINGLQRLVGGNPILLVG NKADILPKSLKRERLIQWMKREAKELGLKPVDVFLVSAGRGQGIREVIDAIEHYRNGK DVYVVGCTNVGKSTFINRIIKEVSGEEDIITTSQFPGTTLDAIEIPLDDGSSLYDTPG IINNHQMAHYVNKKDLKILSPKKELKPRTFQLNDQQTLYFGGLARFDYVSGERSPFIC YMPNELMIHRTKLENADALYEKHAGELLTPPGKDEMDEFPELVAHTFTIKDKKTDIVF SGLGWVTVHDADKKVTAYAPKGVHVFVRRSLI*" /label="rgpH CDS" gene complement(2341696..2342796) /gene="rgpH" /locus_tag="BSU_25670" /old_locus_tag="BSU25670" /label="rgpH gene" CDS complement(2342800..2343318) /gene="yqeG" /locus_tag="BSU_25680" /old_locus_tag="BSU25680" /EC_number="3.1.3.-" /experiment="publication(s) with functional evidences, PMID:27784292" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 27784292; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphatase (active on GMP and Glc-6-P)" /protein_id="NP_390446.1" /db_xref="EnsemblGenomes-Gn:BSU25680" /db_xref="EnsemblGenomes-Tr:CAB14510" /db_xref="GOA:P54452" /db_xref="InterPro:IPR006356" /db_xref="InterPro:IPR006439" /db_xref="InterPro:IPR006549" /db_xref="InterPro:IPR010021" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG11635" /db_xref="UniProtKB/Swiss-Prot:P54452" /translation="MLKKFFLPDEFVKNIFHITPEKLKERNVKGIITDLDNTLVEWDR PNATPRLIEWFEEMKEHGIKVTIVSNNNERRVKLFSEPLGIPFIYKARKPMGKAFNRA VRNMELKKEDCVVIGDQLLTDVLGGNRNGYHTILVVPVASSDGFITRFNRQVERRILS ALKRKGHIQWEE*" /label="yqeG CDS" gene complement(2342800..2343318) /gene="yqeG" /locus_tag="BSU_25680" /old_locus_tag="BSU25680" /label="yqeG gene" promotor_-10 complement(2343228..2343245) /Source="Nicolas_upshift_promotors" /id="U1996" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.415584415584416" /psig="0.415584415584416" /xcortree=2452 /SigmaFactorBS="ttttacctgacgagtttgtaaaaaatatttttcatattACAC ctgagaaattaaaggAACGAAATGTAAAAGGAAttattactgacctggataatacgct t" /listShort="yqeH, aroD, yqeI, nadD, yqeK, yqeL, yqeM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2343242) /Source="Nicolas_upshifts" /id="U1996" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.415584415584416" /psig="0.415584415584416" /xcortree=2452 /SigmaFactorBS="ttttacctgacgagtttgtaaaaaatatttttcatattACAC ctgagaaattaaaggAACGAAATGTAAAAGGAAttattactgacctggataatacgct t" /listShort="yqeH, aroD, yqeI, nadD, yqeK, yqeL, yqeM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2343261..2343264) /Source="Nicolas_upshift_promotors" /id="U1996" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.415584415584416" /psig="0.415584415584416" /xcortree=2452 /SigmaFactorBS="ttttacctgacgagtttgtaaaaaatatttttcatattACAC ctgagaaattaaaggAACGAAATGTAAAAGGAAttattactgacctggataatacgct t" /listShort="yqeH, aroD, yqeI, nadD, yqeK, yqeL, yqeM" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2343319..2343880) /Source="Nicolas_S_feature" /locus_tag="new_2647113_2647674_c" /HighExp="G135, G180, G150, Paraq, Oxctl, C30, Heat, HPh, BMM, LPh" /AntisenseName="sda" /AntisenseCor="-8.6107693225382295E-2" /AntisenseRegPval="-0.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S965" downshifts complement(2343352) /Source="Nicolas_upshifts" /id="D1328" /incds=0 /nref=1 /ntot=1 /MaxReadThrough="6.83118" /MaxDrop="5.26138" /score="9.20556883" /energy="-8.6" /TU="U1998" /idTUdmin="U1999" /TUdmin=616 /isTUend="FALSE" /label="downshifts" promotor_-35 2343543..2343550 /Source="Nicolas_upshift_promotors" /id="U1997" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=2945 /SigmaFactorBS="tactcacaagttatccactttttggtgtggataacagaacga TTGTTCTTatatgcatttCATGGTAGATTAAAGATAACttcaacctcagatgaatgca a" /listShort="S966, sda, S967, S969" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2343561..2343661 /Source="Nicolas_S_feature" /locus_tag="new_2647355_2647455" /HighExp="T3.0H, T-0.40H, MG 150, T5.0H, T-1.40H, T4.0H, T2.30H, T0.0H, T3.30H, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S966" promotor_-10 2343561..2343580 /Source="Nicolas_upshift_promotors" /id="U1997" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=2945 /SigmaFactorBS="tactcacaagttatccactttttggtgtggataacagaacga TTGTTCTTatatgcatttCATGGTAGATTAAAGATAACttcaacctcagatgaatgca a" /listShort="S966, sda, S967, S969" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2343561 /Source="Nicolas_upshifts" /id="U1997" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=2945 /SigmaFactorBS="tactcacaagttatccactttttggtgtggataacagaacga TTGTTCTTatatgcatttCATGGTAGATTAAAGATAACttcaacctcagatgaatgca a" /listShort="S966, sda, S967, S969" /GFF_Attribute="listLong" /label="upshifts" misc_RNA complement(2343611..2343869) /gene="sdaM" /locus_tag="BSU_misc_RNA_80" /product="antisense RNA" /experiment="publication(s) with functional evidences, PMID:20525796" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20525796; Product type n: RNA" /label="sdaM RNA" gene complement(2343611..2343869) /gene="sdaM" /locus_tag="BSU_misc_RNA_80" /label="sdaM gene" CDS 2343662..2343820 /gene="sda" /locus_tag="BSU_25690" /old_locus_tag="BSU25690" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15023339, 16796683, 19040634, 22720735, 28752667" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15023339, 16796683, 19040634, 22720735, 28752667; Product type f: factor" /codon_start=1 /transl_table=11 /product="check point factor coupling initiation of sporulation and replication initiation" /protein_id="YP_054588.1" /db_xref="EnsemblGenomes-Gn:BSU25690" /db_xref="EnsemblGenomes-Tr:CAE01463" /db_xref="GOA:Q7WY62" /db_xref="InterPro:IPR015064" /db_xref="InterPro:IPR036916" /db_xref="PDB:1PV0" /db_xref="PDB:3FYR" /db_xref="SubtiList:BG14183" /db_xref="UniProtKB/Swiss-Prot:Q7WY62" /translation="MNWVPSMRKLSDELLIESYFKATEMNLNRDFIELIENEIKRRSL GHIISVSS*" /label="sda CDS" gene 2343662..2343820 /gene="sda" /locus_tag="BSU_25690" /old_locus_tag="BSU25690" /label="sda gene" S_feature 2343821..2344067 /Source="Nicolas_S_feature" /locus_tag="new_2647615_2647861" /HighExp="Cold, T-0.40H, MG 150, T5.0H, T4.0H, C30, T2.30H, M9-tran, S2, GM 150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S967" promotor_-10 complement(2343868..2343887) /Source="Nicolas_upshift_promotors" /id="U1998" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.509490509490509" /psig="0.999000999001" /xcortree=2592 /SigmaFactorBS="cctctttttaggggtgttttttgctgaaaataGTAGTaaagc gcgcagccaaAGTGATATAATATCAGTCATctgagtaaaaaaaggaaatacgcccgga a" /listShort="S965, yqeG, yqeH, aroD, yqeI, nadD, yqeK, yqeL, yqeM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2343879) /Source="Nicolas_upshifts" /id="U1998" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.509490509490509" /psig="0.999000999001" /xcortree=2592 /SigmaFactorBS="cctctttttaggggtgttttttgctgaaaataGTAGTaaagc gcgcagccaaAGTGATATAATATCAGTCATctgagtaaaaaaaggaaatacgcccgga a" /listShort="S965, yqeG, yqeH, aroD, yqeI, nadD, yqeK, yqeL, yqeM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2343903..2343907) /Source="Nicolas_upshift_promotors" /id="U1998" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.509490509490509" /psig="0.999000999001" /xcortree=2592 /SigmaFactorBS="cctctttttaggggtgttttttgctgaaaataGTAGTaaagc gcgcagccaaAGTGATATAATATCAGTCATctgagtaaaaaaaggaaatacgcccgga a" /listShort="S965, yqeG, yqeH, aroD, yqeI, nadD, yqeK, yqeL, yqeM" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2343931..2344078) /Source="Nicolas_S_feature" /locus_tag="new_2647725_2647872_c" /HighExp="S8, S7, S6, Etha, LBGstat, T0.30H, Salt, BT, LPhT, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99948400000000004" /TUshortSig="SigK, SigA, SigB" /TUshortPSig="1, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S968" downshifts complement(2343968) /Source="Nicolas_upshifts" /id="D1329" /incds=0 /nref=12 /ntot=92 /MaxReadThrough="2.70676" /MaxDrop="4.386" /score="9.20556883" /energy="-8.6" /TU="NA" /idTUdmin="U1999" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 2344024 /Source="Nicolas_upshifts" /id="D1330" /incds=0 /nref=1 /ntot=126 /MaxReadThrough="5.36291" /MaxDrop="2.1106" /score="10.3636587" /energy="-6.2" /TU="U1997" /idTUdmin="U1997" /TUdmin="-1056" /isTUend="FALSE" /label="downshifts" S_feature 2344069..2345122 /Source="Nicolas_S_feature" /locus_tag="new_2647863_2648916" /HighExp="T-0.40H, Cold, M40t90, T0.0H, C30, Glucon, S2, T1.30H, T2.30H, T2.0H" /AntisenseName="yqeF" /AntisenseCor="-0.39616310996746001" /AntisenseRegPval="-10.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S969" promotor_-10 complement(2344073..2344092) /Source="Nicolas_upshift_promotors" /id="U1999" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1228 /SigmaFactorBS="cctgcagcgttgagccggacaaccGCCTAGTCCGatttattt ctccTACATAGGCTGTTATAAAACcttattaaggaggcgcttcacatgtatggcgcag g" /listShort="S968" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2344078) /Source="Nicolas_upshifts" /id="U1999" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1228 /SigmaFactorBS="cctgcagcgttgagccggacaaccGCCTAGTCCGatttattt ctccTACATAGGCTGTTATAAAACcttattaaggaggcgcttcacatgtatggcgcag g" /listShort="S968" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2344105..2344114) /Source="Nicolas_upshift_promotors" /id="U1999" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1228 /SigmaFactorBS="cctgcagcgttgagccggacaaccGCCTAGTCCGatttattt ctccTACATAGGCTGTTATAAAACcttattaaggaggcgcttcacatgtatggcgcag g" /listShort="S968" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2344126..2344857) /gene="yqeF" /locus_tag="BSU_25700" /old_locus_tag="BSU25700" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative lipoprotein; putative esterase" /protein_id="NP_390447.1" /db_xref="EnsemblGenomes-Gn:BSU25700" /db_xref="EnsemblGenomes-Tr:CAB14511" /db_xref="GOA:P54451" /db_xref="InterPro:IPR013830" /db_xref="InterPro:IPR036514" /db_xref="SubtiList:BG11634" /db_xref="UniProtKB/Swiss-Prot:P54451" /translation="MKHFIILFLLLFVTAGCEGRGYEDVVAFGDSNTRGSNWDYRDYP KAQQWVNILKTAERGNLDILNAGIGGQTTEDARLRFQTDVLDQKPKYLFIMFGTNDAA ILTEGKPRVSKQRFRENLVYFIEESRKHGIKPILMTCIPIIEGNGKHHLFYYSRYQAA AFEPKGGARKWHNSYNDITRDVSKRLDVPLVDNWKHFIEADGGKATDEALIQSGLIDP SGNHMTPKGARIVYEGIQDGQILQR*" /label="yqeF CDS" gene complement(2344126..2344857) /gene="yqeF" /locus_tag="BSU_25700" /old_locus_tag="BSU25700" /label="yqeF gene" promotor_-10 complement(2344876..2344895) /Source="Nicolas_upshift_promotors" /id="U2000" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.380619380619381" /psig=1 /xcortree=2739 /SigmaFactorBS="taactataggaaaaaacagtgatagcgaaaaactcttCATTG AAcgaagagaaacagAGGTATAACATTAAAGTGAGgcttttgggggtgtaaagatgaa a" /listShort="yqeF, S968" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2344892) /Source="Nicolas_upshifts" /id="U2000" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.380619380619381" /psig=1 /xcortree=2739 /SigmaFactorBS="taactataggaaaaaacagtgatagcgaaaaactcttCATTG AAcgaagagaaacagAGGTATAACATTAAAGTGAGgcttttgggggtgtaaagatgaa a" /listShort="yqeF, S968" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2344894..2345002) /Source="Nicolas_S_feature" /locus_tag="new_2648688_2648796_c" /HighExp="Etha, Salt, Gly, S8, C30, S7, LPhT, Sw, Heat, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S970" promotor_-35 complement(2344909..2344915) /Source="Nicolas_upshift_promotors" /id="U2000" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.380619380619381" /psig=1 /xcortree=2739 /SigmaFactorBS="taactataggaaaaaacagtgatagcgaaaaactcttCATTG AAcgaagagaaacagAGGTATAACATTAAAGTGAGgcttttgggggtgtaaagatgaa a" /listShort="yqeF, S968" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2345003..2345021) /Source="Nicolas_upshift_promotors" /id="U2001" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=162 /SigmaFactorBS="tttccagtgcggattcaggttattttcttttctttggtttgt gTGTTTTtcagattggaaagaAGGGAATTTTAAAAAATCAtcagctgcgccgcaatga a" /listShort="S970, yqeF, S968" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2345024) /Source="Nicolas_upshifts" /id="U2001" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=162 /SigmaFactorBS="tttccagtgcggattcaggttattttcttttctttggtttgt gTGTTTTtcagattggaaagaAGGGAATTTTAAAAAATCAtcagctgcgccgcaatga a" /listShort="S970, yqeF, S968" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2345036..2345041) /Source="Nicolas_upshift_promotors" /id="U2001" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=162 /SigmaFactorBS="tttccagtgcggattcaggttattttcttttctttggtttgt gTGTTTTtcagattggaaagaAGGGAATTTTAAAAAATCAtcagctgcgccgcaatga a" /listShort="S970, yqeF, S968" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2345109..2345861) /gene="cwlH" /locus_tag="BSU_25710" /old_locus_tag="BSU25710" /EC_number="3.5.1.28" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10515909, 10974124, 15687192" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10515909, 10974124, 15687192; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylmuramoyl-L-alanine amidase" /protein_id="NP_390448.1" /db_xref="EnsemblGenomes-Gn:BSU25710" /db_xref="EnsemblGenomes-Tr:CAB14512" /db_xref="GOA:P54450" /db_xref="InterPro:IPR002477" /db_xref="InterPro:IPR002502" /db_xref="InterPro:IPR036365" /db_xref="InterPro:IPR036366" /db_xref="InterPro:IPR036505" /db_xref="SubtiList:BG11633" /db_xref="UniProtKB/Swiss-Prot:P54450" /translation="MVTIKKDFIPVSNDNRPGYAMAPAYITVHNTANTAKGADAKMHA KFVKNPNTSESWHFTVDDSVIYQHLPIDENGWHAGDGTNGTGNRKSIGIEICENADGD FEKATSNAQWLIRKLMKENNIPLNRVVPHKKWSGKECPRKLLDHWNSFLNGISSSDTP PKETSPSYPLPSGVIKLTSPYRKGTNILQLQKALAVLHFYPDKGAKNNGIDGVYGPKT ANAVKRFQLMNGLTADGIYGPKTKAKLKSKLK*" /label="cwlH CDS" gene complement(2345109..2345861) /gene="cwlH" /locus_tag="BSU_25710" /old_locus_tag="BSU25710" /label="cwlH gene" downshifts complement(2345112) /Source="Nicolas_upshifts" /id="D1331" /incds=0 /nref=4 /ntot=10 /MaxReadThrough="1.29819" /MaxDrop="4.65121" /score="4.6304411" /energy="-10.7" /TU="NA" /idTUdmin="U2003" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 2345240..2345246 /Source="Nicolas_upshift_promotors" /id="U2002" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=171 /SigmaFactorBS="ctgttttcggtccgtaaactccatctatgccatTGTTTTTgg ctcccttatcaGGGTAAAAGTGAAGTACAGctaaagccttttgcagctggagaatgtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2345260..2345278 /Source="Nicolas_upshift_promotors" /id="U2002" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=171 /SigmaFactorBS="ctgttttcggtccgtaaactccatctatgccatTGTTTTTgg ctcccttatcaGGGTAAAAGTGAAGTACAGctaaagccttttgcagctggagaatgtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2345267 /Source="Nicolas_upshifts" /id="U2002" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=171 /SigmaFactorBS="ctgttttcggtccgtaaactccatctatgccatTGTTTTTgg ctcccttatcaGGGTAAAAGTGAAGTACAGctaaagccttttgcagctggagaatgtt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2345871..2345890) /Source="Nicolas_upshift_promotors" /id="U2003" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.898101898101898" /psig="0.898101898101898" /xcortree=1426 /SigmaFactorBS="caggttaagaacacaattcttttttacctcataaaaaaGGCT GTCCAtctctctgttttcTGCATTCTTATTAATAGGGAgggatagaaatggtaaccat a" /listShort="cwlH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2345890) /Source="Nicolas_upshifts" /id="U2003" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.898101898101898" /psig="0.898101898101898" /xcortree=1426 /SigmaFactorBS="caggttaagaacacaattcttttttacctcataaaaaaGGCT GTCCAtctctctgttttcTGCATTCTTATTAATAGGGAgggatagaaatggtaaccat a" /listShort="cwlH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2345904..2345912) /Source="Nicolas_upshift_promotors" /id="U2003" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.898101898101898" /psig="0.898101898101898" /xcortree=1426 /SigmaFactorBS="caggttaagaacacaattcttttttacctcataaaaaaGGCT GTCCAtctctctgttttcTGCATTCTTATTAATAGGGAgggatagaaatggtaaccat a" /listShort="cwlH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2345956..2345963 /Source="Nicolas_upshift_promotors" /id="U2004" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.694305694305694" /psig=1 /xcortree=1830 /SigmaFactorBS="aggtaaaaaagaattgtgttcttaacctggttttCAGTTGAA cagctgaaatggcaCCAGTTATACTAATTTAGATgacggaggttttgactcctgacat c" /listShort="S971, yqeD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2345978..2345997 /Source="Nicolas_upshift_promotors" /id="U2004" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.694305694305694" /psig=1 /xcortree=1830 /SigmaFactorBS="aggtaaaaaagaattgtgttcttaacctggttttCAGTTGAA cagctgaaatggcaCCAGTTATACTAATTTAGATgacggaggttttgactcctgacat c" /listShort="S971, yqeD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2345982..2346047 /Source="Nicolas_S_feature" /locus_tag="new_2649776_2649841" /HighExp="dia15, H2O2, C30, G180, Heat, S8, Paraq, Oxctl, LBGexp, Etha" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S971" upshifts 2345982 /Source="Nicolas_upshifts" /id="U2004" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.694305694305694" /psig=1 /xcortree=1830 /SigmaFactorBS="aggtaaaaaagaattgtgttcttaacctggttttCAGTTGAA cagctgaaatggcaCCAGTTATACTAATTTAGATgacggaggttttgactcctgacat c" /listShort="S971, yqeD" /GFF_Attribute="listLong" /label="upshifts" CDS 2346048..2346674 /gene="yqeD" /locus_tag="BSU_25720" /old_locus_tag="BSU25720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 15855514, 16850406" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="NP_390449.1" /db_xref="EnsemblGenomes-Gn:BSU25720" /db_xref="EnsemblGenomes-Tr:CAB14513" /db_xref="GOA:P54449" /db_xref="InterPro:IPR015414" /db_xref="InterPro:IPR032816" /db_xref="SubtiList:BG11632" /db_xref="UniProtKB/Swiss-Prot:P54449" /translation="MLKKVIGILVIIAIISVGFFQKEAWLDAIKAGGMFSVLFSMLLI AADVFFPIVPFALIAALNGAVFGTANGIWITLTGSMLGTILLFFLARYSFRDWARKKV QAYPAIQSYEASFNKNAFTAVLLGRLIPVIPSLVMNVICGLSQVRWHVFFFASLIGKI PNIVVVTIAGANFTSNKLLSISIYGTYILIIMLVIYKKFPHLLKVPKK*" /label="yqeD CDS" gene 2346048..2346674 /gene="yqeD" /locus_tag="BSU_25720" /old_locus_tag="BSU25720" /label="yqeD gene" downshifts 2346642 /Source="Nicolas_upshifts" /id="D1332" /incds=0 /nref=2 /ntot=63 /MaxReadThrough="2.9326" /MaxDrop="2.91074" /score="15.7108141" /energy="-10.3" /TU="U2004" /idTUdmin="U2004" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(2346693..2347586) /gene="yqeC" /locus_tag="BSU_25730" /old_locus_tag="BSU25730" /EC_number="1.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10658669, 15231785; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative catabolic 6-phospho-gluconate dehydrogenase (NAD[+]-dependent)" /protein_id="NP_390450.1" /db_xref="EnsemblGenomes-Gn:BSU25730" /db_xref="EnsemblGenomes-Tr:CAB14514" /db_xref="GOA:P54448" /db_xref="InterPro:IPR004849" /db_xref="InterPro:IPR006114" /db_xref="InterPro:IPR006115" /db_xref="InterPro:IPR006183" /db_xref="InterPro:IPR006184" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11631" /db_xref="UniProtKB/Swiss-Prot:P54448" /translation="MKIGLIGLGKMGINIGKQFIDRNHQVVGYDVNQAAVDELKAYGA EGTTNLKEFISLLHPPRILWVMVPHGIVDAVLRDVSPLLSKGDMIIEAGNSHYKESIR RYNQMKEAGIHYLDAGTSGGMEGARHGACFMVGGDHEAWEIVEPLFRDTAVENGYLYA GEAGSGHFLKMIHNGIEYGMMAAIGEGFEVLENSQFDFDYEKVARVWNHGSVIRSWLM GLTERAFAKDAKLDQIKGIMHSSGEGKWTVETALDLQTATPVIAMSLMMRYRSLTDDT FTGKVVAALRNEFGGHATEKK*" /label="yqeC CDS" gene complement(2346693..2347586) /gene="yqeC" /locus_tag="BSU_25730" /old_locus_tag="BSU25730" /label="yqeC gene" downshifts complement(2346718) /Source="Nicolas_upshifts" /id="D1333" /incds=0 /nref=4 /ntot=12 /MaxReadThrough="1.46947" /MaxDrop="3.03963" /score="0.698755756" /energy="-8.4" /TU="NA" /idTUdmin="U2003" /TUdmin="-1606" /isTUend="FALSE" /label="downshifts" promotor_-35 2347769..2347775 /Source="Nicolas_upshift_promotors" /id="U2005" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.874125874125874" /psig="0.998001998001998" /xcortree=3104 /SigmaFactorBS="tctattactgaatctctttatatccataattatcgctttatc CTTGATTtaccatcagttTAAGTTAAAATATGGGAAGGaattcgattttttcagtaaa a" /listShort="yqeB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2347787..2347806 /Source="Nicolas_upshift_promotors" /id="U2005" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.874125874125874" /psig="0.998001998001998" /xcortree=3104 /SigmaFactorBS="tctattactgaatctctttatatccataattatcgctttatc CTTGATTtaccatcagttTAAGTTAAAATATGGGAAGGaattcgattttttcagtaaa a" /listShort="yqeB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2347787 /Source="Nicolas_upshifts" /id="U2005" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.874125874125874" /psig="0.998001998001998" /xcortree=3104 /SigmaFactorBS="tctattactgaatctctttatatccataattatcgctttatc CTTGATTtaccatcagttTAAGTTAAAATATGGGAAGGaattcgattttttcagtaaa a" /listShort="yqeB" /GFF_Attribute="listLong" /label="upshifts" CDS 2347838..2348560 /gene="yqeB" /locus_tag="BSU_25740" /old_locus_tag="BSU25740" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390451.2" /db_xref="EnsemblGenomes-Gn:BSU25740" /db_xref="EnsemblGenomes-Tr:CAB14515" /db_xref="GOA:P54447" /db_xref="SubtiList:BG11630" /db_xref="UniProtKB/Swiss-Prot:P54447" /translation="MLQNQSHTLIGVTKTAVFFLYAALAIIGFAIGYFIPQIAKWALS LPWIPLEGPLRLITSFQGSTASFITALLGMCAGIWFAHSVIAMLLSVKITDHTVEFIK GKKVQTIHSDDIALVFMDHKRLVLLGTAGYELVREEIDEKPVNVEKAFRQHHYEWATD GDPFKDQFRRWIPDAPDLSQGAHALLKARHKALQDEEKDDIEEFRLELAQLGIVVRDE GTRQYWRKAETYPPKIQLGEGL*" /label="yqeB CDS" gene 2347838..2348560 /gene="yqeB" /locus_tag="BSU_25740" /old_locus_tag="BSU25740" /label="yqeB gene" CDS complement(2348593..2349003) /gene="nucB" /locus_tag="BSU_25750" /old_locus_tag="BSU25750" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7746143, 17209033, 21179489" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7746143, 17209033, 21179489; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sporulation-specific matrix degrading exported DNase" /protein_id="NP_390452.1" /db_xref="EnsemblGenomes-Gn:BSU25750" /db_xref="EnsemblGenomes-Tr:CAB14516" /db_xref="GOA:P42983" /db_xref="InterPro:IPR029476" /db_xref="SubtiList:BG11237" /db_xref="UniProtKB/Swiss-Prot:P42983" /translation="MKKWMAGLFLAAAVLLCLMVPQQIQGASSYDKVLYFPLSRYPET GSHIRDAIAEGHPDICTIDRDGADKRREESLKGIPTKPGYDRDEWPMAVCEEGGAGAD VRYVTPSDNRGAGSWVGNQMSSYPDGTRVLFIVQ*" /label="nucB CDS" gene complement(2348593..2349003) /gene="nucB" /locus_tag="BSU_25750" /old_locus_tag="BSU25750" /label="nucB gene" downshifts complement(2348618) /Source="Nicolas_upshifts" /id="D1334" /incds=0 /nref=2 /ntot=20 /MaxReadThrough="0.80212" /MaxDrop="3.40706" /score="-0.144589925" /energy="-9.3" /TU="NA" /idTUdmin="U2006" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2349023..2349041) /Source="Nicolas_upshift_promotors" /id="U2006" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1115 /SigmaFactorBS="cagcatactaacttcaaatgttaAAAATAttcttcatcaagc gcCCATACATTGAAATGAACAaaggtatggggggatggggatgaaaaaatggatggca g" /listShort="nucB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2349025) /Source="Nicolas_upshifts" /id="U2006" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1115 /SigmaFactorBS="cagcatactaacttcaaatgttaAAAATAttcttcatcaagc gcCCATACATTGAAATGAACAaaggtatggggggatggggatgaaaaaatggatggca g" /listShort="nucB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2349057..2349062) /Source="Nicolas_upshift_promotors" /id="U2006" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1115 /SigmaFactorBS="cagcatactaacttcaaatgttaAAAATAttcttcatcaagc gcCCATACATTGAAATGAACAaaggtatggggggatggggatgaaaaaatggatggca g" /listShort="nucB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2349126..2349134 /Source="Nicolas_upshift_promotors" /id="U2007" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp="0.595404595404595" /psig="0.595404595404595" /xcortree=1062 /SigmaFactorBS="ttaccaaagccggactcccccgcgagaaatttcccggtaCAG ACACAGacagcctcccggtCACATACATTTACATATAGGcttttgcctacatactttt g" /listShort="spoIVCB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2349147 /Source="Nicolas_upshifts" /id="U2007" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp="0.595404595404595" /psig="0.595404595404595" /xcortree=1062 /SigmaFactorBS="ttaccaaagccggactcccccgcgagaaatttcccggtaCAG ACACAGacagcctcccggtCACATACATTTACATATAGGcttttgcctacatactttt g" /listShort="spoIVCB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2349148..2349167 /Source="Nicolas_upshift_promotors" /id="U2007" /multdbtbs="SigE,SigK" /comp="M5" /sig="SigK" /pcomp="0.595404595404595" /psig="0.595404595404595" /xcortree=1062 /SigmaFactorBS="ttaccaaagccggactcccccgcgagaaatttcccggtaCAG ACACAGacagcctcccggtCACATACATTTACATATAGGcttttgcctacatactttt g" /listShort="spoIVCB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2349199..2349669 /gene="sigKn" /locus_tag="BSU_25760" /old_locus_tag="BSU25760" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8464402, 7704261, 2536191, 2163341, 10974124, 15187183, 20889742" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8464402, 7704261, 2536191, 2163341, 10974124, 15187183, 20889742; Product type r: regulator" /pseudo /codon_start=1 /transl_table=11 /product="RNA polymerase sporulation-specific sigma-K factor precursor (Sigma-27) (N-terminal half)" /db_xref="GOA:P12254" /db_xref="InterPro:IPR000943" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR007630" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="PSEUDO:CAB14517.2" /db_xref="SubtiList:BG10459" /db_xref="UniProtKB/Swiss-Prot:P12254" /translation="MVTGVFAALGFVVKELVFLVSYVKNNAFPQPLSSSEEKKYLELM AKGDEHARNMLIEHNLRLVAHIVKKFENTGEDAEDLISIGTIGLIKGIESYSAGKGTK LATYAARCIENEIVITKGGCIHPSLIRFNIYGVRIHNGNFFHDKVNNCFFIFKS*" /label="sigKn CDS" gene 2349199..2349669 /gene="sigKn" /locus_tag="BSU_25760" /old_locus_tag="BSU25760" /pseudo /label="sigKn gene" downshifts 2349389 /Source="Nicolas_upshifts" /id="D1335" /incds=1 /nref=2 /ntot=5 /MaxReadThrough="7.53734" /MaxDrop="3.01863" /score="-7.46047649" /energy="-12.1" /TU="U2007" /idTUdmin="U2007" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" downshifts 2349521 /Source="Nicolas_upshifts" /id="D1336" /incds=1 /nref=44 /ntot=61 /MaxReadThrough="0.8049" /MaxDrop="7.21386" /score="-7.46047649" /energy="-12.1" /TU="NA" /idTUdmin="U2007" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2349577..2351079) /gene="spoIVCA" /locus_tag="BSU_25770" /old_locus_tag="BSU25770" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1631085, 2163341, 7704261, 8300549, 8969508, 8655528, 18673456" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1631085, 2163341, 7704261, 8300549, 8969508, 8655528, 18673456; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="site-specific DNA recombinase; skin element" /protein_id="NP_390454.2" /db_xref="EnsemblGenomes-Gn:BSU25770" /db_xref="EnsemblGenomes-Tr:CAB14518" /db_xref="GOA:P17867" /db_xref="InterPro:IPR006118" /db_xref="InterPro:IPR006119" /db_xref="InterPro:IPR011109" /db_xref="InterPro:IPR025827" /db_xref="InterPro:IPR036162" /db_xref="SubtiList:BG10458" /db_xref="UniProtKB/Swiss-Prot:P17867" /translation="MIAIYVRVSTEEQAIKGSSIDSQIEACIKKAGTKDVLKYADEGF SGELLERPALNRLREDASKGLISQVICYDPDRLSRKLMNQLIIDDELRKRNIPLIFVN GEYANSPEGQLFFAMRGAISEFEKAKIKERTSSGRLQKMKKGMIIKDSKLYGYKFVKE KRTLEILEEEAKIIRMIFNYFTDHKSPFFGRVNGIALHLTQMGVKTKKGAKVWHRQVV RQILMNSSYKGEHRQYKYDTEGSYVSKQAGNKSIIKIRPEEEQITVTIPAIVPAEQWD YAQELLGQSKRKHLSISPHNYLLSGLVRCGKCGNTMTGKKRKSHGKDYYVYTCRKNYS GAKDRGCGKEMSENKLNRHVWGEIFKFITNPQKYVSFKEAEQSNHLSDELELIEKEIE KTKKGRKRLLTLISLSDDDDLDIDEIKAQIIELQKKQNQLTEKCNEIQSKMKVLDDTS SSENALKRAIDYFQSIGADNLTLEDKKTIVNFIVKEVTIVDSDTIYIETY*" /label="spoIVCA CDS" gene complement(2349577..2351079) /gene="spoIVCA" /locus_tag="BSU_25770" /old_locus_tag="BSU25770" /label="spoIVCA gene" downshifts complement(2349593) /Source="Nicolas_upshifts" /id="D1337" /incds=1 /nref=21 /ntot=131 /MaxReadThrough="2.50085" /MaxDrop="6.35891" /score="-0.144589925" /energy="-9.3" /TU="NA" /idTUdmin="U2008" /TUdmin=4 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2351186..2351204) /Source="Nicolas_upshift_promotors" /id="U2008" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1098 /SigmaFactorBS="gaaacgtttaataacactatagtttaatttaaaatctcCTCA TTtggacaaacagctgttACATAGCATTACCCAAGGGgtgatgcattttatgaaagtg a" /listShort="spoIVCA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2351204) /Source="Nicolas_upshifts" /id="U2008" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1098 /SigmaFactorBS="gaaacgtttaataacactatagtttaatttaaaatctcCTCA TTtggacaaacagctgttACATAGCATTACCCAAGGGgtgatgcattttatgaaagtg a" /listShort="spoIVCA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2351206..2351507) /Source="Nicolas_S_feature" /locus_tag="new_2655000_2655301_c" /HighExp="dia5, Diami, S8, S7, dia15, C30, G135, S6, G180, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.974" /TUlongSig="NA" /TUlongPSig="NA" /label="S972" promotor_-35 complement(2351221..2351226) /Source="Nicolas_upshift_promotors" /id="U2008" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1098 /SigmaFactorBS="gaaacgtttaataacactatagtttaatttaaaatctcCTCA TTtggacaaacagctgttACATAGCATTACCCAAGGGgtgatgcattttatgaaagtg a" /listShort="spoIVCA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2351528..2351947) /gene="arsC" /locus_tag="BSU_25780" /old_locus_tag="BSU25780" /EC_number="1.20.4.4" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:11698660, 16192272, 16905151, 8760915, 8969508, 9537360, 17303556, 21258851, 21904062, 23813734" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11698660, 16192272, 16905151, 8760915, 8969508, 9537360, 17303556, 21258851, 21904062, 23813734; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thioredoxin-coupled arsenate reductase; skin element" /protein_id="NP_390455.1" /db_xref="EnsemblGenomes-Gn:BSU25780" /db_xref="EnsemblGenomes-Tr:CAB14519" /db_xref="GOA:P45947" /db_xref="InterPro:IPR014064" /db_xref="InterPro:IPR023485" /db_xref="InterPro:IPR036196" /db_xref="PDB:1JL3" /db_xref="PDB:1Z2D" /db_xref="PDB:1Z2E" /db_xref="PDB:2IPA" /db_xref="SubtiList:BG11304" /db_xref="UniProtKB/Swiss-Prot:P45947" /translation="MENKIIYFLCTGNSCRSQMAEGWAKQYLGDEWKVYSAGIEAHGL NPNAVKAMKEVGIDISNQTSDIIDSDILNNADLVVTLCGDAADKCPMTPPHVKREHWG FDDPARAQGTEEEKWAFFQRVRDEIGNRLKEFAETGK*" /label="arsC CDS" gene complement(2351528..2351947) /gene="arsC" /locus_tag="BSU_25780" /old_locus_tag="BSU25780" /label="arsC gene" downshifts complement(2351552) /Source="Nicolas_upshifts" /id="D1338" /incds=0 /nref=106 /ntot=239 /MaxReadThrough="3.85143" /MaxDrop="6.98965" /score="17.1730317" /energy="-8.6" /TU="U2009" /idTUdmin="U2009" /TUdmin="-1823" /isTUend="FALSE" /label="downshifts" CDS complement(2351959..>2352087) /gene="arsB" /locus_tag="Delta6_pseudo_BSU_25790" /old_locus_tag="BSU25790" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9537360, 15849754, 16850406, 16905151; Product type t: transporter" /codon_start=1 /transl_table=11 /product="arsenite efflux transporter; skin element" /protein_id="NP_390456.2" /db_xref="EnsemblGenomes-Gn:BSU25790" /db_xref="EnsemblGenomes-Tr:CAB14520" /db_xref="GOA:P45946" /db_xref="InterPro:IPR002657" /db_xref="InterPro:IPR004706" /db_xref="SubtiList:BG11303" /db_xref="UniProtKB/Swiss-Prot:P45946" /NCBI_locus_tag="A8O17_RS20905" /modified_by="User" /translation="YRIHSGAAFAAVIGPLVEVPVMIALVKVALWFQRKYFGSHSM*" /label="Delta6_pseudo_BSU_25790" gene complement(2351959..>2352087) /gene="arsB" /locus_tag="Delta6_pseudo_BSU_25790" /old_locus_tag="BSU25790" /NCBI_locus_tag="A8O17_RS20905" /modified_by="User" /label="Delta6_pseudo_BSU_25790" SCAR join(2352083,2352090) /note="deletion occured in betwen marked nucleotides" /created_by="User" /modified_by="User" /label="TFC7A" N_region 2352084..2352089 /note="EcoRV side (GATATC)" /created_by="User" /modified_by="User" /label="TFC7A" CDS <2352085..2352471 /NCBI_locus_tag="A8O17_RS12485" /NCBI_old_locus_tag="A8O17_12485" /inference="COORDINATES: similar to AA sequence:RefSeq:NP_390515.1" /note="incomplete; partial in the middle of a contig; missing N-terminus; Derived by automated computational analysis using gene prediction method: Protein Homology." /pseudo /codon_start=1 /transl_table=11 /product="ImmA/IrrE family metallo-endopeptidase" /locus_tag="Delta6_pseudo_BSU_26380" /modified_by="User" /translation="ISSFALKHSGIYNICLDSRKSRTEQWYDFAHEFCHIYRHEGDKK TMPATWTDYLDWQSNYFTYHFCIPTCMLRNINLPYIQSHAIENVAWLFKVSPSFAKKR LSIYYRKLTQHLFSQTVTGNLCPPFL*" /label="Delta6_pseudo_BSU_26380" gene <2352085..2352471 /NCBI_locus_tag="A8O17_RS12485" /NCBI_old_locus_tag="A8O17_12485" /pseudo /locus_tag="Delta6_pseudo_BSU_26380" /modified_by="User" /label="Delta6_pseudo_BSU_26380" misc_feature complement(2352438..2352456) /Source="Nicolas_upshift_promotors" /id="U2034" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.888111888111888" /psig="0.888111888111888" /xcortree=1184 /SigmaFactorBS="acgtctttttttgtttttttcaatgcgcgcaaatgcatgagg atttcattattcattacaaaaaggggggGCATAAATTTCCCGTAACAgtttgactaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 2352453..2352869 /gene="sigKc" /locus_tag="BSU_26390" /old_locus_tag="BSU26390" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:2163341, 7704261, 8969508" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2163341, 7704261, 8969508; Product type f: factor" /pseudo /codon_start=1 /transl_table=11 /product="RNA polymerase sporulation-specific sigma-K factor precursor (Sigma-27) (C-terminal fragment)" /db_xref="GOA:P12254" /db_xref="InterPro:IPR000943" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR007630" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="PSEUDO:CAB14580.1" /db_xref="SubtiList:BG10919" /db_xref="UniProtKB/Swiss-Prot:P12254" /translation="MPPLFVMNNEILMHLRALKKTKKDVSLHDPIGQDKEGNEISLID VLKSENEDVIDTIQLNMELEKVKQYIDILDDREKEVIVGRFGLDLKKEKTQREIAKEL GISRSYVSRIEKRALMKMFHEFYRAEKEKRKKAKGK*" /label="sigKc CDS" gene 2352453..2352869 /gene="sigKc" /locus_tag="BSU_26390" /old_locus_tag="BSU26390" /pseudo /label="sigKc gene" misc_feature 2352458..2352472 /Source="Nicolas_upshift_promotors" /id="U2035" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.647352647352647" /psig="0.217782217782218" /xcortree=1060 /SigmaFactorBS="tcaacatttatttagtcaaactgttacgggaaatttatgccC CCCCTTTTTGTAATgaataatgaaatcctcatgcatttgcgcgcattgaaaaaaacaa a" /listShort="spoIIIC, S984" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2352466) /Source="Nicolas_upshifts" /id="U2034" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.888111888111888" /psig="0.888111888111888" /xcortree=1184 /SigmaFactorBS="acgtctttttttgtttttttcaatgcgcgcaaatgcatgagg atttcattattcattacaaaaaggggggGCATAAATTTCCCGTAACAgtttgactaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts 2352477 /Source="Nicolas_upshifts" /id="U2035" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.647352647352647" /psig="0.217782217782218" /xcortree=1060 /SigmaFactorBS="tcaacatttatttagtcaaactgttacgggaaatttatgccC CCCCTTTTTGTAATgaataatgaaatcctcatgcatttgcgcgcattgaaaaaaacaa a" /listShort="spoIIIC, S984" /GFF_Attribute="listLong" /label="upshifts" downshifts 2352853 /Source="Nicolas_upshifts" /id="D1357" /incds=0 /nref=50 /ntot=108 /MaxReadThrough="3.60274" /MaxDrop="5.60264" /score="-0.848064104" /energy="-4.5" /TU="U2035" /idTUdmin="U2033" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS 2352869..2352985 /locus_tag="BSU_26399" /old_locus_tag="BSU26399" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513982.1" /translation="MQKKPDLILRLSLFERVMKIIFFIADKLSEKDRQDRNK*" /label="hypothetical protein CDS" gene 2352869..2352985 /locus_tag="BSU_26399" /old_locus_tag="BSU26399" /label="gene" S_feature 2352898..2354232 /Source="Nicolas_S_feature" /locus_tag="new_2701783_2703117" /HighExp="S8, S6, S7, S5, S4, BT, B36, dia15, C30, H2O2" /AntisenseName="psiE" /AntisenseCor="0.376363934894826" /AntisenseRegPval="-9.8000000000000007" /CDS_PredictionProba="0.117191" /TUshortSig="Sig-" /TUshortPSig="0.218" /TUlongSig="NA" /TUlongPSig="NA" /label="S984" downshifts complement(2353016) /Source="Nicolas_upshifts" /id="D1358" /incds=0 /nref=1 /ntot=20 /MaxReadThrough="3.25265" /MaxDrop="3.18978" /score="3.17084908" /energy="-14.7" /TU="NA" /idTUdmin="U2036" /TUdmin=66 /isTUend="FALSE" /label="downshifts" CDS complement(2353094..2353258) /gene="yrkS" /locus_tag="BSU_26400" /old_locus_tag="BSU26400" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_390517.1" /db_xref="EnsemblGenomes-Gn:BSU26400" /db_xref="EnsemblGenomes-Tr:CAB14581" /db_xref="SubtiList:BG11785" /db_xref="UniProtKB/Swiss-Prot:P54446" /translation="MKVIIIEGLQTDKCMNDCYHYLIKLYRQEIQGDSNISWNKRSRD RASTARSRPV*" /label="yrkS CDS" gene complement(2353094..2353258) /gene="yrkS" /locus_tag="BSU_26400" /old_locus_tag="BSU26400" /label="yrkS gene" promotor_-10 complement(2353188..2353207) /Source="Nicolas_upshift_promotors" /id="U2036" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.824175824175824" /psig="0.975024975024975" /xcortree=1403 /SigmaFactorBS="aggggtgatgtattttatgaaggtaataatcatcgagggact gcaAACTGACAaatgcatgaacgatTGCTATCATTATTTAATAAAactttataggcag g" /listShort="yrkS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2353214) /Source="Nicolas_upshifts" /id="U2036" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.824175824175824" /psig="0.975024975024975" /xcortree=1403 /SigmaFactorBS="aggggtgatgtattttatgaaggtaataatcatcgagggact gcaAACTGACAaatgcatgaacgatTGCTATCATTATTTAATAAAactttataggcag g" /listShort="yrkS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2353222..2353229) /Source="Nicolas_upshift_promotors" /id="U2036" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.824175824175824" /psig="0.975024975024975" /xcortree=1403 /SigmaFactorBS="aggggtgatgtattttatgaaggtaataatcatcgagggact gcaAACTGACAaatgcatgaacgatTGCTATCATTATTTAATAAAactttataggcag g" /listShort="yrkS" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2353392) /Source="Nicolas_upshifts" /id="D1359" /incds=0 /nref=79 /ntot=219 /MaxReadThrough="1.20909" /MaxDrop="4.40328" /score="39.3560776" /energy="-10.6" /TU="NA" /idTUdmin="U2036" /TUdmin="-310" /isTUend="FALSE" /label="downshifts" CDS complement(2353803..2354219) /gene="psiE" /locus_tag="BSU_26410" /old_locus_tag="BSU26410" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12897016, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="phosphate starvation inducible protein" /protein_id="NP_390518.2" /db_xref="EnsemblGenomes-Gn:BSU26410" /db_xref="EnsemblGenomes-Tr:CAB14582" /db_xref="GOA:P54445" /db_xref="InterPro:IPR009315" /db_xref="InterPro:IPR020948" /db_xref="SubtiList:BG11784" /db_xref="UniProtKB/Swiss-Prot:P54445" /translation="MRFSNKFKKVPYLLQALLNVCLFFLALALSALLISETWYIVLFV YKSLFNKVDSYYEMLGELLIFFMYFEFIALIIKYFKSDFHFPLRYFIYIGITAVIRLI IIDHDQAISTFWWAMAILAMICGFFIANRRNSVVEH*" /label="psiE CDS" gene complement(2353803..2354219) /gene="psiE" /locus_tag="BSU_26410" /old_locus_tag="BSU26410" /label="psiE gene" CDS complement(2354265..2355563) /gene="yrkQ" /locus_tag="BSU_26420" /old_locus_tag="BSU26420" /EC_number="2.7.13.3" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YrkP]" /protein_id="NP_390519.1" /db_xref="EnsemblGenomes-Gn:BSU26420" /db_xref="EnsemblGenomes-Tr:CAB14583" /db_xref="GOA:P54444" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG11783" /db_xref="UniProtKB/Swiss-Prot:P54444" /translation="MAHLKFTLTKKLALLIMVAAIVSGVIFLTLQKITDDLIEGYLSS EEYYHEESARYIQKFSKYVSENELSTSDRKAFGEWVKKENYINLTIFKDQELQYDSIY SESDYGKEKLTQYAQNHSHPVKFSDGEGRVIIDGFYSSRYYDLAFALDLLGATLIFLI IVLFGIRQSLRYLKTIHQEIHILEGGELDYEMTIKGHDELAMIAKSIEDLRKAFLDKL KAIEELQAESRSLVTEMSHDMRTPLTSLIMNLEFAKKEGGEAGASKDRYVANAYGKAL QLKSLSDNLFAYFLLNKEYEADLETVAVKEVIYDLISDQIAILHQEHFRVHISGELPE TYINVNLEELGRVFDNVMSNLLKYADPEEKISITFVSDQEIFEIHVSNTIKLADITPE SNGLGERSIARMMSRMQGQFHSIQKNSKYYIVLRFWNTKM*" /label="yrkQ CDS" gene complement(2354265..2355563) /gene="yrkQ" /locus_tag="BSU_26420" /old_locus_tag="BSU26420" /label="yrkQ gene" CDS complement(2355550..2356245) /gene="yrkP" /locus_tag="BSU_26430" /old_locus_tag="BSU26430" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 18175906" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 18175906; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YrkQ]" /protein_id="NP_390520.1" /db_xref="EnsemblGenomes-Gn:BSU26430" /db_xref="EnsemblGenomes-Tr:CAB14584" /db_xref="GOA:P54443" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11782" /db_xref="UniProtKB/Swiss-Prot:P54443" /translation="MAYRILVVEDDEDIGDLLEESLTRAGYEVLRAKDGKRALQLVND SLDLVILDIMMPGISGIETCQHIRKSSNVPILFLTARSSTLDKTEGLLAGGDDYMTKP FSEEELHARVIAQLRRYTIYQEKKEQEETFLIGGKLRVSEEFNEVWKEEKQIKLSDLE YRILKLLMNKRNKIFSAQNIYESVWGQPYFYCSNNTVMVHIRKLRSKIEDDPARPVYI KTEWGRGYRFGAS*" /label="yrkP CDS" gene complement(2355550..2356245) /gene="yrkP" /locus_tag="BSU_26430" /old_locus_tag="BSU26430" /label="yrkP gene" misc_feature complement(2356311..2356328) /Source="Nicolas_upshift_promotors" /id="U2037" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.270729270729271" /psig="0.737262737262737" /xcortree=673 /SigmaFactorBS="acaaatttgtggcgagcatcagctttcataaattgttaagat ttacgtagtaTCTTATAACGTACTTATTactatgaacgatatatagtaaggacacacg a" /listShort="yrkP" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2356320) /Source="Nicolas_upshifts" /id="U2037" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.270729270729271" /psig="0.737262737262737" /xcortree=673 /SigmaFactorBS="acaaatttgtggcgagcatcagctttcataaattgttaagat ttacgtagtaTCTTATAACGTACTTATTactatgaacgatatatagtaaggacacacg a" /listShort="yrkP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2356406..2356412 /Source="Nicolas_upshift_promotors" /id="U2038" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.76023976023976" /psig="0.145854145854146" /xcortree=1734 /SigmaFactorBS="aatttgtcacattttctaaaaaaaatgatgacTCTTCATaaa ttgTTAAGATTCGGTCTTTATAtttatccattgtaaggctcaagtttttcagatccgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2356419..2356437 /Source="Nicolas_upshift_promotors" /id="U2038" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.76023976023976" /psig="0.145854145854146" /xcortree=1734 /SigmaFactorBS="aatttgtcacattttctaaaaaaaatgatgacTCTTCATaaa ttgTTAAGATTCGGTCTTTATAtttatccattgtaaggctcaagtttttcagatccgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2356434 /Source="Nicolas_upshifts" /id="U2038" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.76023976023976" /psig="0.145854145854146" /xcortree=1734 /SigmaFactorBS="aatttgtcacattttctaaaaaaaatgatgacTCTTCATaaa ttgTTAAGATTCGGTCTTTATAtttatccattgtaaggctcaagtttttcagatccgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 2356513..2357730 /gene="yrkO" /locus_tag="BSU_26440" /old_locus_tag="BSU26440" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 21737930; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390521.1" /db_xref="EnsemblGenomes-Gn:BSU26440" /db_xref="EnsemblGenomes-Tr:CAB14585" /db_xref="GOA:P54442" /db_xref="InterPro:IPR007349" /db_xref="SubtiList:BG11781" /db_xref="UniProtKB/Swiss-Prot:P54442" /translation="MIVQKEGRGQPVSLRERVHFLDIVRGFALLGIIIVNYFLIVDSV KGFEMASDDVLHKLVSWFAEGKFVTLFSFLFGVGFMIFMDRAAQKVESPNKLFARRLS ILLGFGILHITFVWVGDILAFYAVSGFLLLAFYKRTAKTVLRWIIALIVFQFLTPVFT MLYNVINTAGSKNPNFSEFTLFSHSSLTYMESISTRWTDMVTMAAGSFSMIYSMFLMF LLGVYFVKMEFFKDMEAKKPIWKRIWIISTIAFLITQSSILLDMFNLSENMLWKDISS VLGQNGGLTGSMFYMSTFAMLFLYLPQLRGPMMIFTKVGRMSLTCYLLHSIIGTVLFL RYGFGLADHIQSAGTFMFSLAVYFVLMSFSTLWLKRFRYGPMELVWRKLTYGKVNGSP KATPLHSEKSIQK*" /label="yrkO CDS" gene 2356513..2357730 /gene="yrkO" /locus_tag="BSU_26440" /old_locus_tag="BSU26440" /label="yrkO gene" promotor_-35 2356972..2356979 /Source="Nicolas_upshift_promotors" /id="U2039" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.844155844155844" /psig="0.999000999001" /xcortree=1907 /SigmaFactorBS="tatcgcacttatcgtgtttcaaTTCCTGACtcctgttttcac aaTGTTGTACAATGTCATCAATactgcagggtcaaaaaacccgaatttttcagagttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2356994..2357013 /Source="Nicolas_upshift_promotors" /id="U2039" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.844155844155844" /psig="0.999000999001" /xcortree=1907 /SigmaFactorBS="tatcgcacttatcgtgtttcaaTTCCTGACtcctgttttcac aaTGTTGTACAATGTCATCAATactgcagggtcaaaaaacccgaatttttcagagttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2357010 /Source="Nicolas_upshifts" /id="U2039" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.844155844155844" /psig="0.999000999001" /xcortree=1907 /SigmaFactorBS="tatcgcacttatcgtgtttcaaTTCCTGACtcctgttttcac aaTGTTGTACAATGTCATCAATactgcagggtcaaaaaacccgaatttttcagagttt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 2357649..2357897 /locus_tag="BSU_26449" /old_locus_tag="BSU26449" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513983.1" /translation="MAQADVRQSKRESQSNSAAFGKIYSEITPLHRLHDFKLVLLNEA GIKRTDLIYGLVIFISFRLLWANKSTRVYSMCIAHDRI*" /label="hypothetical protein CDS" gene 2357649..2357897 /locus_tag="BSU_26449" /old_locus_tag="BSU26449" /label="gene" S_feature complement(2357826..2358873) /Source="Nicolas_S_feature" /locus_tag="new_2706711_2707758_c" /HighExp="Diami, C30, dia15, dia5, Lbstat, S8, C90, G180, H2O2, G135" /AntisenseName="yrkN" /AntisenseCor="0.40539464433869998" /AntisenseRegPval="-11.3" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="1, 0.962, 1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S985" CDS 2358242..2358799 /gene="yrkN" /locus_tag="BSU_26450" /old_locus_tag="BSU26450" /EC_number="2.3.-.-" /function="16.8: Protect" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 18175906; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_390522.1" /db_xref="EnsemblGenomes-Gn:BSU26450" /db_xref="EnsemblGenomes-Tr:CAB14586" /db_xref="GOA:P54441" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG11780" /db_xref="UniProtKB/Swiss-Prot:P54441" /translation="MKTKNEPKVILELAKESDLPEFQKKLQEAFAIAVIETFGDCEDG PIPSDNDVQESFNAPGAVVYHILQDGKNVGGAVVRINSQTNHNSLDLFYVSPEYHSQG IGLSAWKAIEAQYPDTVLWETVTPYFEKRNINFYVNKCGFHIVEFYNEHHSNPHMHRN GREDDKPLLNDDDFFRFVKIMKKKD*" /label="yrkN CDS" gene 2358242..2358799 /gene="yrkN" /locus_tag="BSU_26450" /old_locus_tag="BSU26450" /label="yrkN gene" S_feature 2358800..2358922 /Source="Nicolas_S_feature" /locus_tag="new_2707685_2707807" /HighExp="S8, Sw, C30, S7, BC, C90, Lbstat, Mal, LoTm, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S986" S_feature complement(2358875..2359289) /Source="Nicolas_S_feature" /locus_tag="new_2707760_2708174_c" /HighExp="M0t90, M40t90, Lbstat, dia5, LPhT, dia15, M9-stat, Lbtran, C90, Etha" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="1, 0.962, 1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S987" downshifts complement(2358918) /Source="Nicolas_upshifts" /id="D1360" /incds=0 /nref=81 /ntot=255 /MaxReadThrough="5.45539" /MaxDrop="5.6563" /score="-3.35079978" /energy="-23.7" /TU="U2041,U2042,U2044,U2045" /idTUdmin="U2042" /TUdmin="-182" /isTUend="FALSE" /label="downshifts" CDS complement(2359290..2359814) /gene="yrkL" /locus_tag="BSU_26470" /old_locus_tag="BSU26470" /EC_number="1.6.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11053405; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NAD(P)H oxidoreductase" /protein_id="NP_390524.2" /db_xref="EnsemblGenomes-Gn:BSU26470" /db_xref="EnsemblGenomes-Tr:CAB14588" /db_xref="GOA:P54439" /db_xref="InterPro:IPR003680" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG11778" /db_xref="UniProtKB/Swiss-Prot:P54439" /translation="MKTLVIVIHPNLETSVVNKTWMNRLKQEKDITVHDLYGEYPNFI IDVEKEQQLLLDHERIVFQFPMYWYSSPALLKQWEDDVLTHGWAYGTGGTKLHGKELL LAISLGAQESDYQAGGEYNITISELIRPFQVTANYIGMRFLPAFTQYGTLHLSKEDVK NSAERLVDYLKAEH*" /label="yrkL CDS" gene complement(2359290..2359814) /gene="yrkL" /locus_tag="BSU_26470" /old_locus_tag="BSU26470" /label="yrkL gene" promotor_-35 2359662..2359669 /Source="Nicolas_upshift_promotors" /id="U2040" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.972027972027972" /psig="0.996003996003996" /xcortree=458 /SigmaFactorBS="cgatacgctcatgatctaacaggagctgCTGCTCTTtttcta catcAATGATAAAATTAGGGTATTcaccgtacaggtcatgaaccgtaatgtctttctc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2359680..2359699 /Source="Nicolas_upshift_promotors" /id="U2040" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.972027972027972" /psig="0.996003996003996" /xcortree=458 /SigmaFactorBS="cgatacgctcatgatctaacaggagctgCTGCTCTTtttcta catcAATGATAAAATTAGGGTATTcaccgtacaggtcatgaaccgtaatgtctttctc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2359694 /Source="Nicolas_upshifts" /id="U2040" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.972027972027972" /psig="0.996003996003996" /xcortree=458 /SigmaFactorBS="cgatacgctcatgatctaacaggagctgCTGCTCTTtttcta catcAATGATAAAATTAGGGTATTcaccgtacaggtcatgaaccgtaatgtctttctc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2359815..2359902) /Source="Nicolas_S_feature" /locus_tag="new_2708700_2708787_c" /HighExp="dia5, Etha, dia15, M9-stat, M0t90, Lbtran, Diami, C90, T3.0H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="1, 0.962, 1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S988" promotor_-10 complement(2359897..2359916) /Source="Nicolas_upshift_promotors" /id="U2041" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2050 /SigmaFactorBS="tcatcattgattttggtgcccaatTAGTTGCCctgaattcat gaaaAAGGATAAAATAGGTGTAAAtaaagttgctattttaaaattagaatcaattcat t" /listShort="S988, yrkL, S987, S985" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2359902) /Source="Nicolas_upshifts" /id="U2041" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2050 /SigmaFactorBS="tcatcattgattttggtgcccaatTAGTTGCCctgaattcat gaaaAAGGATAAAATAGGTGTAAAtaaagttgctattttaaaattagaatcaattcat t" /listShort="S988, yrkL, S987, S985" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2359904..2360057) /Source="Nicolas_S_feature" /locus_tag="new_2708789_2708942_c" /HighExp="M0t90, M9-stat, Lbstat, M40t90, T1.30H, C90, Lbtran, T0.30H, dia15, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.962, 1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S989" promotor_-35 complement(2359931..2359938) /Source="Nicolas_upshift_promotors" /id="U2041" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2050 /SigmaFactorBS="tcatcattgattttggtgcccaatTAGTTGCCctgaattcat gaaaAAGGATAAAATAGGTGTAAAtaaagttgctattttaaaattagaatcaattcat t" /listShort="S988, yrkL, S987, S985" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2360058..2360534) /gene="yrkK" /locus_tag="BSU_26480" /old_locus_tag="BSU26480" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390525.2" /db_xref="EnsemblGenomes-Gn:BSU26480" /db_xref="EnsemblGenomes-Tr:CAB14589" /db_xref="GOA:P54438" /db_xref="InterPro:IPR025671" /db_xref="SubtiList:BG11777" /db_xref="UniProtKB/Swiss-Prot:P54438" /translation="MVYFVAFFCFAITLHNIEEAIWLPEWSQQSSKFQKPVTSNEFHF AVIVITMLAYLSAFGFLYMPESDIAKWIFIGFLGSMVINAIFPHLIATVVMKKYAPGL LTGLLLNIPVNSLVIYQMFLKNLIVWKELIISTLVVGIILLALIPLLFKVGDKVSP*" /label="yrkK CDS" gene complement(2360058..2360534) /gene="yrkK" /locus_tag="BSU_26480" /old_locus_tag="BSU26480" /label="yrkK gene" promotor_-10 complement(2360570..2360589) /Source="Nicolas_upshift_promotors" /id="U2042" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.553446553446553" /psig="0.962037962037962" /xcortree=3147 /SigmaFactorBS="caactactaaggcagattcttctctcttttaacaCCATATCC aatcagcctcaaaTGTAATATAATGTTGCCAAAccatattggttgtggcaccgaggag g" /listShort="yrkK, S989, S988, yrkL, S987, S985" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2360584) /Source="Nicolas_upshifts" /id="U2042" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.553446553446553" /psig="0.962037962037962" /xcortree=3147 /SigmaFactorBS="caactactaaggcagattcttctctcttttaacaCCATATCC aatcagcctcaaaTGTAATATAATGTTGCCAAAccatattggttgtggcaccgaggag g" /listShort="yrkK, S989, S988, yrkL, S987, S985" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2360586..2361116) /Source="Nicolas_S_feature" /locus_tag="new_2709471_2710001_c" /HighExp="Diami, dia15, S8, G180, Etha, G135, S6, S0, G150, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S990" promotor_-35 complement(2360603..2360610) /Source="Nicolas_upshift_promotors" /id="U2042" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.553446553446553" /psig="0.962037962037962" /xcortree=3147 /SigmaFactorBS="caactactaaggcagattcttctctcttttaacaCCATATCC aatcagcctcaaaTGTAATATAATGTTGCCAAAccatattggttgtggcaccgaggag g" /listShort="yrkK, S989, S988, yrkL, S987, S985" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2361117..2361902) /gene="yrkJ" /locus_tag="BSU_26490" /old_locus_tag="BSU26490" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_390526.1" /db_xref="EnsemblGenomes-Gn:BSU26490" /db_xref="EnsemblGenomes-Tr:CAB14590" /db_xref="GOA:P54437" /db_xref="InterPro:IPR002781" /db_xref="SubtiList:BG11776" /db_xref="UniProtKB/Swiss-Prot:P54437" /translation="MDIAFITTLFIIGFIGAFISGMIGIGGAVINYPMLLYIPSLVGV MSLTAHEVSGIGAIQVFFATLGGVWAYRKSGLINKTLIIYMGSSILLGSVLGSYFSHY ISEKGINFIYGILAIIAVILMFIPKKGQKGQEHSEDKEVIFNKWLASSLAFIIGGVSG ILGAGGAFILVPIMLSILNIPVRVTVASSLAITFLSSIGATVGKVITGQVLFVPALVL MITSLIASPIGASVGQKVNTKFLQWVLAQLIGATAIKIWLELL*" /label="yrkJ CDS" gene complement(2361117..2361902) /gene="yrkJ" /locus_tag="BSU_26490" /old_locus_tag="BSU26490" /label="yrkJ gene" CDS complement(2361963..2362190) /gene="yrkI" /locus_tag="BSU_26500" /old_locus_tag="BSU26500" /function="5.5: Sulfur metabolism" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9555915; Product type c: carrier" /codon_start=1 /transl_table=11 /product="putative sulfur-carrier protein" /protein_id="NP_390527.1" /db_xref="EnsemblGenomes-Gn:BSU26500" /db_xref="EnsemblGenomes-Tr:CAB14591" /db_xref="GOA:P54436" /db_xref="InterPro:IPR001455" /db_xref="InterPro:IPR036868" /db_xref="SubtiList:BG11775" /db_xref="UniProtKB/Swiss-Prot:P54436" /translation="MKSDKVLDAKGLACPMPIVRTKKAMNELESGQILEVHATDKGAK NDLTAWSKSGGHDLLEQTDEGDILKFWIQKG*" /label="yrkI CDS" gene complement(2361963..2362190) /gene="yrkI" /locus_tag="BSU_26500" /old_locus_tag="BSU26500" /label="yrkI gene" downshifts complement(2361987) /Source="Nicolas_upshifts" /id="D1361" /incds=0 /nref=4 /ntot=22 /MaxReadThrough="5.31659" /MaxDrop="3.95633" /score="-3.35079978" /energy="-23.7" /TU="U2044,U2045" /idTUdmin="U2046" /TUdmin=3085 /isTUend="FALSE" /label="downshifts" CDS complement(2362224..2363357) /gene="yrkH" /locus_tag="BSU_26510" /old_locus_tag="BSU26510" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sulfur transferase / hydrolase" /protein_id="NP_390528.2" /db_xref="EnsemblGenomes-Gn:BSU26510" /db_xref="EnsemblGenomes-Tr:CAB14592" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR001763" /db_xref="InterPro:IPR036866" /db_xref="InterPro:IPR036873" /db_xref="SubtiList:BG11774" /db_xref="UniProtKB/Swiss-Prot:P54435" /translation="MKHDRKGNDPKRSDKKIFNKEPLFILDVRNENDFSDWKIEGHDF DHLNVPYFDLLDGVEDILEKIPSDKEVLVVCAKEGSSVMVSEMLSEAGHSVSYLKGGM KAWSEHLEPVKVGDLKDGGEMYQFVRIGKGCLSYMVISNGEAAIIDATRMVNFFIDFA KGKGATITHVFDTHLHADHISGGRVIAEKTKATYWLPPKDAEEVEFDYQPLEEGNDII IGNTTIKIQPIYSPGHTIGSTSFIVDDQYLLSGDILFIDSIGRPDLAGMAEDWVGDLR KTLYSRYKALSKDLIVLPAHFMIIDELNENGSVGKQLSTLFSENHGLNIADETEFRHL VTDHLPPQPNAYQEIRETNMGKISPDEEKQREMEIGPNRCAIR*" /label="yrkH CDS" gene complement(2362224..2363357) /gene="yrkH" /locus_tag="BSU_26510" /old_locus_tag="BSU26510" /label="yrkH gene" misc_feature complement(2363059..2363074) /Source="Nicolas_upshift_promotors" /id="U2043" /multdbtbs="-" /comp="M19" /sig="Sig-" /pcomp="0.410589410589411" /psig="0.477522477522478" /xcortree=1482 /SigmaFactorBS="aaaagaaggttcatccgtcatggtatccgaaatgctttctga agcaggtcattctgTATCCTACCTTAAGGGtggaatgaaagcatggagcgaacattta g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2363070) /Source="Nicolas_upshifts" /id="U2043" /multdbtbs="-" /comp="M19" /sig="Sig-" /pcomp="0.410589410589411" /psig="0.477522477522478" /xcortree=1482 /SigmaFactorBS="aaaagaaggttcatccgtcatggtatccgaaatgctttctga agcaggtcattctgTATCCTACCTTAAGGGtggaatgaaagcatggagcgaacattta g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2363358..2363691) /Source="Nicolas_S_feature" /locus_tag="new_2712243_2712576_c" /HighExp="Diami, dia15, Sw, BC, S0, G180, dia5, G135, M9-stat, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99950300000000003" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S991" CDS complement(2363692..2364249) /gene="yrkF" /locus_tag="BSU_26530" /old_locus_tag="BSU26530" /function="5.5: Sulfur metabolism" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative rhodanese-related sulfur transferase" /protein_id="NP_390530.1" /db_xref="EnsemblGenomes-Gn:BSU26530" /db_xref="EnsemblGenomes-Tr:CAB14594" /db_xref="InterPro:IPR001455" /db_xref="InterPro:IPR001763" /db_xref="InterPro:IPR036868" /db_xref="InterPro:IPR036873" /db_xref="SubtiList:BG11772" /db_xref="UniProtKB/Swiss-Prot:P54433" /translation="MMKATIVLDAKGLACPMPIVKTKKRMKDLKAGEVLEIHATDKGS TADLEAWAKSTGHEYLGTEAEGEILRHFLRKGGEHSSENASSIPEISLEAFKQKVDSD ESLNILDVREIEEYEKAHIPGVVHIPLGEVEKRANELNENDEIYIICHSGRRSEMAAR TMKKQGFKKVINVVPGMRDWTGKTE*" /label="yrkF CDS" gene complement(2363692..2364249) /gene="yrkF" /locus_tag="BSU_26530" /old_locus_tag="BSU26530" /label="yrkF gene" S_feature complement(2364250..2364434) /Source="Nicolas_S_feature" /locus_tag="new_2713135_2713319_c" /HighExp="Diami, dia15, Sw, BC, S8, dia5, G180, S7, S0, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.12629799999999999" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S992" CDS complement(2364435..2364917) /gene="yrkE" /locus_tag="BSU_26540" /old_locus_tag="BSU26540" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative protein involved in sulfur metabolism (DsrE-like)" /protein_id="NP_390531.1" /db_xref="EnsemblGenomes-Gn:BSU26540" /db_xref="EnsemblGenomes-Tr:CAB14595" /db_xref="InterPro:IPR027396" /db_xref="InterPro:IPR032836" /db_xref="SubtiList:BG11771" /db_xref="UniProtKB/Swiss-Prot:P54432" /translation="MTEQTKRTTIVLFSGDYDKAMAAYIIANGAAAYDHEVTIFHTFW GFNALRKEELIPVKKGFLEKMFGKMMPRGADKMGLSKMNFAGMGPKMIKNVMKKHNVL TLPQLIEMAQEQGVKLVACTMTMDLLGLQEKELLDDIDYAGVAAYLADAEEGSVNLFI *" /label="yrkE CDS" gene complement(2364435..2364917) /gene="yrkE" /locus_tag="BSU_26540" /old_locus_tag="BSU26540" /label="yrkE gene" S_feature complement(2364918..2365026) /Source="Nicolas_S_feature" /locus_tag="new_2713803_2713911_c" /HighExp="Diami, dia15, Sw, BC, dia5, S8, G180, S6, Oxctl, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S993" CDS complement(2365064..2365255) /gene="yrkD" /locus_tag="BSU_26550" /old_locus_tag="BSU26550" /function="5.5: Sulfur metabolism" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 21339296; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative metal-sensitive transcriptional regulator involved in sulfur metabolism" /protein_id="NP_390532.1" /db_xref="EnsemblGenomes-Gn:BSU26550" /db_xref="EnsemblGenomes-Tr:CAB14596" /db_xref="GOA:P54431" /db_xref="InterPro:IPR003735" /db_xref="SubtiList:BG11770" /db_xref="UniProtKB/Swiss-Prot:P54431" /translation="MMEQGKDCREVVTQLAASRNAIDRAMGLIVSTNLEHCVRESLEK GEDTQNLVKEAVDLLVKSR*" /label="yrkD CDS" gene complement(2365064..2365255) /gene="yrkD" /locus_tag="BSU_26550" /old_locus_tag="BSU26550" /label="yrkD gene" downshifts complement(2365071) /Source="Nicolas_upshifts" /id="D1362" /incds=0 /nref=153 /ntot=252 /MaxReadThrough="8.17686" /MaxDrop="5.42995" /score="-6.39526496" /energy="-7.9" /TU="U2044,U2045" /idTUdmin="U2046" /TUdmin=1 /isTUend="TRUE" /label="downshifts" S_feature complement(2365256..2365345) /Source="Nicolas_S_feature" /locus_tag="new_2714141_2714230_c" /HighExp="Diami, dia15, S6, S7, S8, Etha, dia5, S5, BC, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigK" /TUshortPSig="1, 0.998, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S994" CDS complement(2365346..2365663) /gene="yrzM" /locus_tag="BSU_26558" /old_locus_tag="BSU26558" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /db_xref="PSEUDO:CAX52666.1" /translation="MIIIATYRRYYPITGISCIHKDKLEAMDITILDIRHYNDVANFS DNIILNIPYAYLKRFYLEIPRDKIHIIARDRVELNLGVRFLKRKGIHVNSYELATCKC KNK*" /label="yrzM CDS" gene complement(2365346..2365663) /gene="yrzM" /locus_tag="BSU_26558" /old_locus_tag="BSU26558" /pseudo /label="yrzM gene" promotor_-10 complement(2365452..2365471) /Source="Nicolas_upshift_promotors" /id="U2044" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.661338661338661" /psig=1 /xcortree=1899 /SigmaFactorBS="aatattattttaaacatcccatatgcgtatctaaaacgTTTT TATttagagattccaCGTGATAAAATACACATAATagctcgtgaccgggtggaattaa a" /listShort="S994, yrkD, S993, yrkE, S992, yrkF, S991, yrkH, yrkI, yrkJ, S990, yrkK, S989, S988, yrkL, S987, S985" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2365468) /Source="Nicolas_upshifts" /id="U2044" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.661338661338661" /psig=1 /xcortree=1899 /SigmaFactorBS="aatattattttaaacatcccatatgcgtatctaaaacgTTTT TATttagagattccaCGTGATAAAATACACATAATagctcgtgaccgggtggaattaa a" /listShort="S994, yrkD, S993, yrkE, S992, yrkF, S991, yrkH, yrkI, yrkJ, S990, yrkK, S989, S988, yrkL, S987, S985" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2365484..2365490) /Source="Nicolas_upshift_promotors" /id="U2044" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.661338661338661" /psig=1 /xcortree=1899 /SigmaFactorBS="aatattattttaaacatcccatatgcgtatctaaaacgTTTT TATttagagattccaCGTGATAAAATACACATAATagctcgtgaccgggtggaattaa a" /listShort="S994, yrkD, S993, yrkE, S992, yrkF, S991, yrkH, yrkI, yrkJ, S990, yrkK, S989, S988, yrkL, S987, S985" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2365705..2365920) /gene="yrzN" /locus_tag="BSU_26559" /old_locus_tag="BSU26559" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="PSEUDO:CAX52667.1" /translation="MINKADLKLNRLIALFEFLLAELALSNVSIFSIRGYRNESISSK KVTFTLDYIPMGVYYCFVNKQRVNKVV*" /label="yrzN CDS" gene complement(2365705..2365920) /gene="yrzN" /locus_tag="BSU_26559" /old_locus_tag="BSU26559" /pseudo /label="yrzN gene" promotor_-10 complement(2365733..2365752) /Source="Nicolas_upshift_promotors" /id="U2045" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.728271728271728" /psig="0.998001998001998" /xcortree=1794 /SigmaFactorBS="tgaatctatcagctcaaagaaagtaactttcacACTTGACTa tatacctatggggGTATATTATTGTTTTGTGAAtaaacaaagagttaataaggtggtg t" /listShort="yrzM, S994, yrkD, S993, yrkE, S992, yrkF, S991, yrkH, yrkI, yrkJ, S990, yrkK, S989, S988, yrkL, S987, S985" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2365747) /Source="Nicolas_upshifts" /id="U2045" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.728271728271728" /psig="0.998001998001998" /xcortree=1794 /SigmaFactorBS="tgaatctatcagctcaaagaaagtaactttcacACTTGACTa tatacctatggggGTATATTATTGTTTTGTGAAtaaacaaagagttaataaggtggtg t" /listShort="yrzM, S994, yrkD, S993, yrkE, S992, yrkF, S991, yrkH, yrkI, yrkJ, S990, yrkK, S989, S988, yrkL, S987, S985" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2365767..2365774) /Source="Nicolas_upshift_promotors" /id="U2045" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.728271728271728" /psig="0.998001998001998" /xcortree=1794 /SigmaFactorBS="tgaatctatcagctcaaagaaagtaactttcacACTTGACTa tatacctatggggGTATATTATTGTTTTGTGAAtaaacaaagagttaataaggtggtg t" /listShort="yrzM, S994, yrkD, S993, yrkE, S992, yrkF, S991, yrkH, yrkI, yrkJ, S990, yrkK, S989, S988, yrkL, S987, S985" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2365921..2366047) /Source="Nicolas_S_feature" /locus_tag="new_2714806_2714932_c" /HighExp="S6, S7, S8, S5, BT, B36, G/S, BC, Pyr, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.114547" /TUshortSig="SigK, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S995" CDS complement(2366048..2366608) /gene="yrkC" /locus_tag="BSU_26560" /old_locus_tag="BSU26560" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10704478; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme; cupin family" /protein_id="NP_390533.1" /db_xref="EnsemblGenomes-Gn:BSU26560" /db_xref="EnsemblGenomes-Tr:CAB14597" /db_xref="GOA:P54430" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR013096" /db_xref="InterPro:IPR014710" /db_xref="SubtiList:BG11769" /db_xref="UniProtKB/Swiss-Prot:P54430" /translation="MYYNPFSPQCYYYVTVPMYNDGRSVYWTIPNEMEKVHRGADLRS SYEDRNLLLKDYGPKPFVVNINRATKQNNTFRTALWTGKHFQVTLMSLGIGEDIGLEI HPNVDQFLRIEQGRGIVKMGKSKDHLNFQRNVYDDSAIVVPAGTWHNVINTGNTPLKL YSIYAPPNHPFGTVHETKADAVAAED*" /label="yrkC CDS" gene complement(2366048..2366608) /gene="yrkC" /locus_tag="BSU_26560" /old_locus_tag="BSU26560" /label="yrkC gene" CDS complement(2366625..2366801) /locus_tag="BSU_26569" /old_locus_tag="BSU26569" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513984.1" /translation="MLTKASEIQHLENDYKVGDKLFIHESNGDRTFIFVFNMSFLDLA HSLNKCIGYYHKNL*" /label="hypothetical protein CDS" gene complement(2366625..2366801) /locus_tag="BSU_26569" /old_locus_tag="BSU26569" /label="gene" promotor_-10 complement(2366635..2366654) /Source="Nicolas_upshift_promotors" /id="U2046" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1282 /SigmaFactorBS="catttttgtgtttaatatgagttttcttgaTTTAGCACACtc ccttaataaaTGCATAGGATACTATCACAAaaatttataattgcggggatcaaaaaat g" /listShort="yrkC, S995, yrzN, yrzM, S994, yrkD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2366646) /Source="Nicolas_upshifts" /id="U2046" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1282 /SigmaFactorBS="catttttgtgtttaatatgagttttcttgaTTTAGCACACtc ccttaataaaTGCATAGGATACTATCACAAaaatttataattgcggggatcaaaaaat g" /listShort="yrkC, S995, yrzN, yrzM, S994, yrkD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2366648..2366833) /Source="Nicolas_S_feature" /locus_tag="new_2715533_2715718_c" /HighExp="BC, Sw, S3, dia15, Etha, S4, S5, H2O2, LBGtran, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.49093999999999999" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S996" promotor_-35 complement(2366667..2366676) /Source="Nicolas_upshift_promotors" /id="U2046" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1282 /SigmaFactorBS="catttttgtgtttaatatgagttttcttgaTTTAGCACACtc ccttaataaaTGCATAGGATACTATCACAAaaatttataattgcggggatcaaaaaat g" /listShort="yrkC, S995, yrzN, yrzM, S994, yrkD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2366834..2366980) /gene="yrkB" /locus_tag="BSU_26570" /old_locus_tag="BSU26570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_390534.1" /db_xref="EnsemblGenomes-Gn:BSU26570" /db_xref="EnsemblGenomes-Tr:CAB14598" /db_xref="SubtiList:BG11768" /db_xref="UniProtKB/Swiss-Prot:P54429" /translation="MLLKNWPSRRIQRDKSKRAGIGGTNNRIPYTLLLCYVNVQKPFR IVDL*" /label="yrkB CDS" gene complement(2366834..2366980) /gene="yrkB" /locus_tag="BSU_26570" /old_locus_tag="BSU26570" /label="yrkB gene" CDS complement(2367150..2367971) /gene="bltR" /locus_tag="BSU_26580" /old_locus_tag="BSU26580" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:7608059, 9083003, 10200972, 21954605" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7608059, 9083003, 10200972, 21954605; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (polyamine metabolism)" /protein_id="NP_390535.1" /db_xref="EnsemblGenomes-Gn:BSU26580" /db_xref="EnsemblGenomes-Tr:CAB14599" /db_xref="GOA:P39842" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="InterPro:IPR011256" /db_xref="SubtiList:BG10904" /db_xref="UniProtKB/Swiss-Prot:P39842" /translation="MSEDVKKYFTTGEFSKLCRVKKQTLFHYDEIGLFSPEIKKENGY RYYSYHQFETFQVISLFKELGVPLKEIKCLIKGKTPDKILHVLKEKSIEIDKKINELK QLQTILQTKVTLTEQALETDFSSISFEYLNEETFMLSRKTLNLPERKYVAAISELIHE VQQYELDEGYPIGGIFAREQILEKDFYNYSYFYIKVKDGAENINYHVRPKGLYAVGYE IGGNTEEAYRRIIEFIERNGMQIGENAYEEYMLDEMVVDGYENTYAKILLQVKEV*" /label="bltR CDS" gene complement(2367150..2367971) /gene="bltR" /locus_tag="BSU_26580" /old_locus_tag="BSU26580" /label="bltR gene" promotor_-35 2367979..2367986 /Source="Nicolas_upshift_promotors" /id="U2048" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig="0.997002997002997" /xcortree=1531 /SigmaFactorBS="acttcttaacatcttcgctcataaaaaccTCCTTGACtatac ggtaaccataTACCTTATGATTTGATTGTActtgaaaaaagcttcaagcgaaaaggat a" /listShort="blt" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(2367981..2368000) /Source="Nicolas_upshift_promotors" /id="U2047" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.561438561438561" /psig="0.966033966033966" /xcortree=1901 /SigmaFactorBS="tttttacctatccttttcgcttgaagcttttttcaagtacaa tcaaatcataaggtatATGGTTACCGTATAGTCAAGgaggtttttatgagcgaagatg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2367998) /Source="Nicolas_upshifts" /id="U2047" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.561438561438561" /psig="0.966033966033966" /xcortree=1901 /SigmaFactorBS="tttttacctatccttttcgcttgaagcttttttcaagtacaa tcaaatcataaggtatATGGTTACCGTATAGTCAAGgaggtttttatgagcgaagatg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2368000..2370004) /Source="Nicolas_S_feature" /locus_tag="new_2716885_2718889_c" /HighExp="BC, Sw, Salt, Mal, T4.0H, M9-stat, T3.30H, G180, G135, MG 5" /AntisenseName="blt" /AntisenseCor="0.56943492854420497" /AntisenseRegPval="-23.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S997" promotor_-10 2368002..2368021 /Source="Nicolas_upshift_promotors" /id="U2048" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig="0.997002997002997" /xcortree=1531 /SigmaFactorBS="acttcttaacatcttcgctcataaaaaccTCCTTGACtatac ggtaaccataTACCTTATGATTTGATTGTActtgaaaaaagcttcaagcgaaaaggat a" /listShort="blt" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2368010 /Source="Nicolas_upshifts" /id="U2048" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.983016983016983" /psig="0.997002997002997" /xcortree=1531 /SigmaFactorBS="acttcttaacatcttcgctcataaaaaccTCCTTGACtatac ggtaaccataTACCTTATGATTTGATTGTActtgaaaaaagcttcaagcgaaaaggat a" /listShort="blt" /GFF_Attribute="listLong" /label="upshifts" CDS 2368088..2369290 /gene="blt" /locus_tag="BSU_26590" /old_locus_tag="BSU26590" /function="16.1: Circulate" /function="16.4: Excrete" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9083003, 10200972, 10359661, 12793527, 15849754, 16850406, 19114526, 21954605" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9083003, 10200972, 10359661, 12793527, 15849754, 16850406, 19114526, 21954605; Product type t: transporter" /codon_start=1 /transl_table=11 /product="efflux transporter (promiscuous, acetylated polyamines efflux)" /protein_id="NP_390536.1" /db_xref="EnsemblGenomes-Gn:BSU26590" /db_xref="EnsemblGenomes-Tr:CAB14600" /db_xref="GOA:P39843" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR004734" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10905" /db_xref="UniProtKB/Swiss-Prot:P39843" /translation="MKKSINEQKTIFIILLSNIFVAFLGIGLIIPVMPSFMKIMHLSG STMGYLVAAFAISQLITSPFAGRWVDRFGRKKMIILGLLIFSLSELIFGLGTHVSIFY FSRILGGVSAAFIMPAVTAYVADITTLKERSKAMGYVSAAISTGFIIGPGAGGFIAGF GIRMPFFFASAIALIAAVTSVFILKESLSIEERHQLSSHTKESNFIKDLKRSIHPVYF IAFIIVFVMAFGLSAYETVFSLFSDHKFGFTPKDIAAIITISSIVAVVIQVLLFGKLV NKLGEKRMIQLCLITGAILAFVSTVMSGFLTVLLVTCFIFLAFDLLRPALTAHLSNMA GNQQGFVAGMNSTYTSLGNIFGPALGGILFDLNIHYPFLFAGFVMIVGLGLTMVWKEK KNDAAALN*" /label="blt CDS" gene 2368088..2369290 /gene="blt" /locus_tag="BSU_26590" /old_locus_tag="BSU26590" /label="blt gene" CDS 2369459..2369917 /gene="bltD" /locus_tag="BSU_26600" /old_locus_tag="BSU26600" /EC_number="2.3.1.57" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10200972, 10359661, 12793527, 9083003, 16210326, 21954605, 28197687" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10200972, 10359661, 12793527, 9083003, 16210326, 21954605, 28197687; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spermine/spermidine acetyltransferase" /protein_id="NP_390537.1" /db_xref="EnsemblGenomes-Gn:BSU26600" /db_xref="EnsemblGenomes-Tr:CAB14601" /db_xref="GOA:P39909" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR027455" /db_xref="SubtiList:BG10906" /db_xref="UniProtKB/Swiss-Prot:P39909" /translation="MSINIKAVTDDNRAAILDLHVSQNQLSYIESTKVCLEDAKECHY YKPVGLYYEGDLVGFAMYGLFPEYDEDNKNGRVWLDRFFIDERYQGKGLGKKMLKALI QHLAELYKCKRIYLSIFENNIHAIRLYQRFGFQFNGELDFNGEKVMVKEL*" /label="bltD CDS" gene 2369459..2369917 /gene="bltD" /locus_tag="BSU_26600" /old_locus_tag="BSU26600" /label="bltD gene" downshifts complement(2370049) /Source="Nicolas_upshifts" /id="D1363" /incds=0 /nref=77 /ntot=211 /MaxReadThrough="5.09534" /MaxDrop="4.8114" /score="-0.00168005652" /energy="-10.7" /TU="U2049" /idTUdmin="U2051" /TUdmin=3845 /isTUend="FALSE" /label="downshifts" CDS complement(2370074..2371378) /gene="yrkA" /locus_tag="BSU_26610" /old_locus_tag="BSU26610" /function="16.8: Protect" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative membrane associated protein" /protein_id="NP_390538.1" /db_xref="EnsemblGenomes-Gn:BSU26610" /db_xref="EnsemblGenomes-Tr:CAB14602" /db_xref="GOA:P54428" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR002550" /db_xref="InterPro:IPR005170" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR036318" /db_xref="SubtiList:BG11767" /db_xref="UniProtKB/Swiss-Prot:P54428" /translation="MTTINLIIFTLLIVLTAFFVATEFAIVKIRSSKIDQLILEGKKG AISAKKVITHLDEYLSACQLGITVTALGIGWVGESTFEVILHPLFAHFHVSETVSHVL ILVIAFVMATFLHVVVGELAPKTLAIQKAETITLLTAKPIIWFYRILFPFIWFLNGSA RFIVGLFGLKPASEHELAHSEEELRILLSESYKSGEINQNELKYVNNIFEFDERIAKE IMIPRREIVAISSEDSYETIVKIIKTESYTRYPVLNGDKDSIIGFINAKEFLSAYIDT DQKIKEDFKLENHINPVIHVIESVPIHDVLVKMQKERTHIAILVDEYGGTSGLVTAED ILEEIVGEIRDEFDKDEVPNIRKVNDNHYILDSKVLIEDVNDLLGTTLASDEVDTIGG WFMTQQIDAAVGSVIEADGYIFKVHETVGRHINYLEIVRKKE*" /label="yrkA CDS" gene complement(2370074..2371378) /gene="yrkA" /locus_tag="BSU_26610" /old_locus_tag="BSU26610" /label="yrkA gene" S_feature complement(2371379..2371458) /Source="Nicolas_S_feature" /locus_tag="new_2720264_2720343_c" /HighExp="BC, Sw, MG 15, Mal, Salt, MG 25, MG-0.2, MG 45, MG 5, M/G" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S998" promotor_-10 complement(2371444..2371463) /Source="Nicolas_upshift_promotors" /id="U2049" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=1760 /SigmaFactorBS="atacggaaaaagatgattatttacatcattcagAGTTGATTt taggttcttttgaACTTATAATGTTATATATACtgttttttgtttattcaataaatat t" /listShort="S998, yrkA, S997, bltR, yrkB, S996, yrkC, S995" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2371458) /Source="Nicolas_upshifts" /id="U2049" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=1760 /SigmaFactorBS="atacggaaaaagatgattatttacatcattcagAGTTGATTt taggttcttttgaACTTATAATGTTATATATACtgttttttgtttattcaataaatat t" /listShort="S998, yrkA, S997, bltR, yrkB, S996, yrkC, S995" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2371478..2371485) /Source="Nicolas_upshift_promotors" /id="U2049" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=1760 /SigmaFactorBS="atacggaaaaagatgattatttacatcattcagAGTTGATTt taggttcttttgaACTTATAATGTTATATATACtgttttttgtttattcaataaatat t" /listShort="S998, yrkA, S997, bltR, yrkB, S996, yrkC, S995" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2371641..2371784) /gene="yrzO" /locus_tag="BSU_26619" /old_locus_tag="BSU26619" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097765.1" /db_xref="EnsemblGenomes-Gn:BSU26619" /db_xref="EnsemblGenomes-Tr:CAX52668" /db_xref="InterPro:IPR025417" /db_xref="UniProtKB/Swiss-Prot:C0H458" /translation="MFEGLLFFISAGIVCELAAINRNGRKNIKQQAELIQILKENLYK DIK*" /label="yrzO CDS" gene complement(2371641..2371784) /gene="yrzO" /locus_tag="BSU_26619" /old_locus_tag="BSU26619" /label="yrzO gene" CDS complement(2371802..2372767) /gene="yrdR" /locus_tag="BSU_26620" /old_locus_tag="BSU26620" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_390539.1" /db_xref="EnsemblGenomes-Gn:BSU26620" /db_xref="EnsemblGenomes-Tr:CAB14603" /db_xref="GOA:O07086" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG12289" /db_xref="UniProtKB/Swiss-Prot:O07086" /translation="MKKGQLFIGALTCLVASMSWGAMFPVADHALEFVDPFYFSFIRY GVVTIMLVILLLVREGKKSFHLEGKAKWIILFGVMAFTIYNVLIFLGQRLMGKSGIMT ASIAEALMPMLSIVILWGYKHVKPKKYTMISILIAFLGASMVITKGNISFFFSLGDHL FSILFIFIGVLGWVVYTMGGQIFREWSTLRYSTLTCLFGTAITGIMTAILTAQGYVSV PSIKVIAAIKYDFLFMITLPGIIALLSWNYGIKILSSINGILFINFVPITTLLIMVIK GYNITAFDIVGTLFVIIGLILNNIYQRKEDYKQVLQKEKTNLTIT*" /label="yrdR CDS" gene complement(2371802..2372767) /gene="yrdR" /locus_tag="BSU_26620" /old_locus_tag="BSU26620" /label="yrdR gene" promotor_-35 2372805..2372808 /Source="Nicolas_upshift_promotors" /id="U2050" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.601398601398601" /psig="0.905094905094905" /xcortree=1788 /SigmaFactorBS="aaattacaatgagaaTTATaaaaagaagtaagcATCAAGTAA AATGAACAAAAgtgatgaaaaacatcattgataatgatactttaatgaaggggggatc t" /listShort="yrdQ, S999" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2372823..2372842 /Source="Nicolas_upshift_promotors" /id="U2050" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.601398601398601" /psig="0.905094905094905" /xcortree=1788 /SigmaFactorBS="aaattacaatgagaaTTATaaaaagaagtaagcATCAAGTAA AATGAACAAAAgtgatgaaaaacatcattgataatgatactttaatgaaggggggatc t" /listShort="yrdQ, S999" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2372850 /Source="Nicolas_upshifts" /id="U2050" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.601398601398601" /psig="0.905094905094905" /xcortree=1788 /SigmaFactorBS="aaattacaatgagaaTTATaaaaagaagtaagcATCAAGTAA AATGAACAAAAgtgatgaaaaacatcattgataatgatactttaatgaaggggggatc t" /listShort="yrdQ, S999" /GFF_Attribute="listLong" /label="upshifts" CDS 2372893..2373759 /gene="czcR" /locus_tag="BSU_26630" /old_locus_tag="BSU26630" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 22666466, 25437189; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (LysR family)" /protein_id="NP_390540.1" /db_xref="EnsemblGenomes-Gn:BSU26630" /db_xref="EnsemblGenomes-Tr:CAB14604" /db_xref="GOA:P71025" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12288" /db_xref="UniProtKB/Swiss-Prot:P71025" /translation="MELRDLQIFKCVAHHKSITGAAKELNYVQSNVTARIKQLENELK TPLFNRHKKGVSLSPEGRKMIEYVNKILKDVEELEQVFLDTEIPSGILKIGTVETVRI LPTIIASYYKKYPNVDLSLQAGLTEELIKKVMNHELDGAFISGPLKHSILEQYDVYTE KLTLVTSNKTFNIEDFSTTPILVFNQGCGYRSRLEQWLKDEGVLPNRMMEFNILETIL NSVALGLGITVVPESAVMHLAVQGKVYCHPLPEKDSCISTIFIRHKDAYLTNSMRSLL KTIVEHKNMSMA*" /label="czcR CDS" gene 2372893..2373759 /gene="czcR" /locus_tag="BSU_26630" /old_locus_tag="BSU26630" /label="czcR gene" S_feature 2373760..2373860 /Source="Nicolas_S_feature" /locus_tag="new_2722645_2722745" /HighExp="HiTm, dia15, LBGstat, LPhT, T0.30H, Diami, Paraq, dia5, H2O2, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.905" /TUlongSig="NA" /TUlongPSig="NA" /label="S999" downshifts 2373818 /Source="Nicolas_upshifts" /id="D1364" /incds=0 /nref=6 /ntot=135 /MaxReadThrough="2.57006" /MaxDrop="3.43983" /score="-6.36950065" /energy="-7" /TU="NA" /idTUdmin="U2050" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2373882..2374919) /gene="yrdP" /locus_tag="BSU_26640" /old_locus_tag="BSU26640" /EC_number="1.14.-.-" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9099864, 12100555, 12527699; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_390541.1" /db_xref="EnsemblGenomes-Gn:BSU26640" /db_xref="EnsemblGenomes-Tr:CAB14605" /db_xref="GOA:O07085" /db_xref="InterPro:IPR000103" /db_xref="InterPro:IPR000960" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG11980" /db_xref="UniProtKB/Swiss-Prot:O07085" /translation="MYDTIVIGAGQAGISIGYYLKQSDQKFIILDKSHEVGESWKDRY DSLVLFTSRMYSSLPGMHLEGEKHGFPSKNEIVAYLKKYVKKFEIPIQLRTEVISVLK IKNYFLIKTNREEYQTKNLVIATGPFHTPNIPSISKDLSDNINQLHSSQYKNSKQLAY GNVLVVGGGNSGAQIAVELSKERVTYLACSNKLVYFPLMIGKRSIFWWFDKLGVLHAS HTSIVGKFIQKKGDPVFGHELKHAIKQKEIILKKRVIAAKQNEIIFKDSSTLEVNNII WATGFRNPLCWINIKGVLDQEGRIIHHRGVSPVEGLYFIGLPWQHKRGSALLQGVGND AEYIVKQMNGE*" /label="yrdP CDS" gene complement(2373882..2374919) /gene="yrdP" /locus_tag="BSU_26640" /old_locus_tag="BSU26640" /label="yrdP gene" downshifts complement(2373894) /Source="Nicolas_upshifts" /id="D1365" /incds=0 /nref=30 /ntot=134 /MaxReadThrough="2.50972" /MaxDrop="5.83595" /score="2.19797168" /energy="-12.5" /TU="NA" /idTUdmin="U2051" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2374920..2375006) /Source="Nicolas_S_feature" /locus_tag="new_2723805_2723891_c" /HighExp="LBGtran, dia5, Gly, Diami, LBGstat, M0t45, LBGexp, Lbtran, dia0, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.907, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1000" CDS complement(2375007..2375942) /gene="czcD" /locus_tag="BSU_26650" /old_locus_tag="BSU26650" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10735849, 12100555, 15849754, 15948947, 16850406, 22447126, 26787764, 27210016" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10735849, 12100555, 15849754, 15948947, 16850406, 22447126, 26787764, 27210016; Product type t: transporter" /codon_start=1 /transl_table=11 /product="potassium/proton-divalent cation antiporter" /protein_id="NP_390542.1" /db_xref="EnsemblGenomes-Gn:BSU26650" /db_xref="EnsemblGenomes-Tr:CAB14606" /db_xref="GOA:O07084" /db_xref="InterPro:IPR002524" /db_xref="InterPro:IPR027469" /db_xref="InterPro:IPR027470" /db_xref="InterPro:IPR036837" /db_xref="SubtiList:BG11931" /db_xref="UniProtKB/Swiss-Prot:O07084" /translation="MGHNHNEGANKKVLLISFIMITGYMIIEAIGGFLTNSLALLSDA GHMLSDSISLMVALIAFTLAEKKANHNKTFGYKRFEILAAVINGAALILISLYIIYEA IERFSNPPKVATTGMLTISIIGLVVNLLVAWIMMSGGDTKNNLNIRGAYLHVISDMLG SVGAILAAILIIFFGWGWADPLASIIVAILVLRSGYNVTKDSIHILMEGTPENIDVSD IIRTIEGTEGIQNIHDLHIWSITSGLNALSCHAVVDDQLTISESENILRKIEHELEHK GITHVTIQMETEAHNHDNAILCQPKMEKQRDHHHH*" /label="czcD CDS" gene complement(2375007..2375942) /gene="czcD" /locus_tag="BSU_26650" /old_locus_tag="BSU26650" /label="czcD gene" promotor_-10 complement(2375977..2375996) /Source="Nicolas_upshift_promotors" /id="U2051" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.809190809190809" /psig="0.907092907092907" /xcortree=1543 /SigmaFactorBS="ctcatatataaatattatttgtatcaTGTTAGAAtgcttcat aacagaTTTGAAATAATAAATACATAtgtattaaaaactttaggtaaggaggagtttt t" /listShort="czcD, S1000, yrdP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2375984) /Source="Nicolas_upshifts" /id="U2051" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.809190809190809" /psig="0.907092907092907" /xcortree=1543 /SigmaFactorBS="ctcatatataaatattatttgtatcaTGTTAGAAtgcttcat aacagaTTTGAAATAATAAATACATAtgtattaaaaactttaggtaaggaggagtttt t" /listShort="czcD, S1000, yrdP" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2375986..2376069) /Source="Nicolas_S_feature" /locus_tag="new_2724871_2724954_c" /HighExp="dia5, Gly, LBGtran, Diami, LBGstat, LBGexp, LoTm, dia0, Lbexp, M0t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1001" promotor_-35 complement(2376011..2376018) /Source="Nicolas_upshift_promotors" /id="U2051" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.809190809190809" /psig="0.907092907092907" /xcortree=1543 /SigmaFactorBS="ctcatatataaatattatttgtatcaTGTTAGAAtgcttcat aacagaTTTGAAATAATAAATACATAtgtattaaaaactttaggtaaggaggagtttt t" /listShort="czcD, S1000, yrdP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2376050..2376069) /Source="Nicolas_upshift_promotors" /id="U2052" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.546453546453546" /psig=1 /xcortree=1541 /SigmaFactorBS="gaataattaaggaggtattgtggatttctataaaaatatTTT GACATttcagtaaagagcAGATATATTTATATATGAACacatgctcatatataaatat t" /listShort="S1001, czcD, S1000, yrdP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2376069) /Source="Nicolas_upshifts" /id="U2052" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.546453546453546" /psig=1 /xcortree=1541 /SigmaFactorBS="gaataattaaggaggtattgtggatttctataaaaatatTTT GACATttcagtaaagagcAGATATATTTATATATGAACacatgctcatatataaatat t" /listShort="S1001, czcD, S1000, yrdP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2376083..2376090) /Source="Nicolas_upshift_promotors" /id="U2052" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.546453546453546" /psig=1 /xcortree=1541 /SigmaFactorBS="gaataattaaggaggtattgtggatttctataaaaatatTTT GACATttcagtaaagagcAGATATATTTATATATGAACacatgctcatatataaatat t" /listShort="S1001, czcD, S1000, yrdP" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2376204) /Source="Nicolas_upshifts" /id="D1366" /incds=0 /nref=1 /ntot=41 /MaxReadThrough="3.75163" /MaxDrop="3.57795" /score="38.5313506" /energy="-18.1" /TU="NA" /idTUdmin="U2051" /TUdmin="-2310" /isTUend="FALSE" /label="downshifts" CDS complement(2376229..2376618) /gene="yrdN" /locus_tag="BSU_26660" /old_locus_tag="BSU26660" /EC_number="5.3.2.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative tautomerase" /protein_id="NP_390543.1" /db_xref="EnsemblGenomes-Gn:BSU26660" /db_xref="EnsemblGenomes-Tr:CAB14607" /db_xref="GOA:P94502" /db_xref="InterPro:IPR004370" /db_xref="InterPro:IPR014347" /db_xref="SubtiList:BG12287" /db_xref="UniProtKB/Swiss-Prot:P94502" /translation="MPLLRFDLIEGRDQSSLKKLLDVAHNVVVEAFDVPQQDRYQIVH EHPENHMIIEDTGLGFNRTKNLVVLSVTSKSRPEEKKQKFYRLLAERLESECGIASTD LIVSIVENDNADWSFGLGEAQFLTGKL*" /label="yrdN CDS" gene complement(2376229..2376618) /gene="yrdN" /locus_tag="BSU_26660" /old_locus_tag="BSU26660" /label="yrdN gene" promotor_-35 2376866..2376873 /Source="Nicolas_upshift_promotors" /id="U2053" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.525474525474525" /psig="0.998001998001998" /xcortree=2368 /SigmaFactorBS="ttagaaatcatttattcttctaagctttAGTTTACAtgaagc tctgctatcATATATAATTCAAAATTAAGatggaagacatctcaaaatcagatatcaa c" /listShort="gltR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2376889..2376908 /Source="Nicolas_upshift_promotors" /id="U2053" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.525474525474525" /psig="0.998001998001998" /xcortree=2368 /SigmaFactorBS="ttagaaatcatttattcttctaagctttAGTTTACAtgaagc tctgctatcATATATAATTCAAAATTAAGatggaagacatctcaaaatcagatatcaa c" /listShort="gltR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2376898 /Source="Nicolas_upshifts" /id="U2053" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.525474525474525" /psig="0.998001998001998" /xcortree=2368 /SigmaFactorBS="ttagaaatcatttattcttctaagctttAGTTTACAtgaagc tctgctatcATATATAATTCAAAATTAAGatggaagacatctcaaaatcagatatcaa c" /listShort="gltR" /GFF_Attribute="listLong" /label="upshifts" CDS 2376952..2377842 /gene="gltR" /locus_tag="BSU_26670" /old_locus_tag="BSU26670" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9023181, 28294562" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9023181, 28294562; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (LysR family)" /protein_id="NP_390544.2" /db_xref="EnsemblGenomes-Gn:BSU26670" /db_xref="EnsemblGenomes-Tr:CAB14608" /db_xref="GOA:P94501" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11942" /db_xref="UniProtKB/Swiss-Prot:P94501" /translation="MNIQLLQVFLTTAREGSISKAALTLNYAQSNVTNKIQQLENDLQ TKLFYRHSRGITLTPPGQILVSYSEKILHTIEEARAAMGESSAPSGPLRIGSMETTAA VWLPQLLAHYNNLYPNVDLNLVTGPTEQQIQAVLHYELNGAFISGPIEHPDLVQEKVL DEEMVLVTSASHPVISSIQDVQTQTMLVFRKGCSYRAKLNHILQEEGLLPIKLMEFGI LEAIIGCVSAGLGISLLPRSIIASHEKEGRIRSHTISDKYSFVSTMFIRRKDTLITPA LSAFLTHMRDHFQIKRPDQS*" /label="gltR CDS" gene 2376952..2377842 /gene="gltR" /locus_tag="BSU_26670" /old_locus_tag="BSU26670" /label="gltR gene" promotor_-35 2377530..2377535 /Source="Nicolas_upshift_promotors" /id="U2054" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1013 /SigmaFactorBS="acacaaacaatgcttgtattccgtaaaggatgCTCATAcaga gcaaagctcaaTCATATCCTGCAAGAAGAAggtttattacctataaaattaatggaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2377551..2377569 /Source="Nicolas_upshift_promotors" /id="U2054" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1013 /SigmaFactorBS="acacaaacaatgcttgtattccgtaaaggatgCTCATAcaga gcaaagctcaaTCATATCCTGCAAGAAGAAggtttattacctataaaattaatggaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2377558 /Source="Nicolas_upshifts" /id="U2054" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1013 /SigmaFactorBS="acacaaacaatgcttgtattccgtaaaggatgCTCATAcaga gcaaagctcaaTCATATCCTGCAAGAAGAAggtttattacctataaaattaatggaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2378000..2378317) /gene="yrdK" /locus_tag="BSU_26680" /old_locus_tag="BSU26680" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_390545.3" /db_xref="EnsemblGenomes-Gn:BSU26680" /db_xref="EnsemblGenomes-Tr:CAB14609" /db_xref="SubtiList:BG12286" /db_xref="UniProtKB/Swiss-Prot:P94500" /translation="MRLYTEYIPNKNKLINQQQYHSDLQDLLHQWILQLLQLDVLPLS NRKYQSSRCHPKSVGEYLIVVRAIDALGNSQPLTSRRNQVSRAMTFVQNSLNEENLHP NID*" /label="yrdK CDS" gene complement(2378000..2378317) /gene="yrdK" /locus_tag="BSU_26680" /old_locus_tag="BSU26680" /label="yrdK gene" CDS complement(2378275..2379597) /gene="brnQ" /locus_tag="BSU_26690" /old_locus_tag="BSU26690" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8544834, 9287000, 9531631, 15849754, 16850406, 25645558" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8544834, 9287000, 9531631, 15849754, 16850406, 25645558; Product type t : transporter" /codon_start=1 /transl_table=11 /product="low-affinity branched-chain amino acid transporter" /protein_id="NP_390546.1" /db_xref="EnsemblGenomes-Gn:BSU26690" /db_xref="EnsemblGenomes-Tr:CAB14610" /db_xref="GOA:P94499" /db_xref="InterPro:IPR004685" /db_xref="SubtiList:BG11918" /db_xref="UniProtKB/Swiss-Prot:P94499" /translation="MSKKVSASYIIIIGLMLFALFFGAGNLIFPPMLGQLAGKNVWVA NAGFLVTGVGLPLLAITAFVFSGKQNLQSLASRVHPVFGIVFTTILYLAIGPFFAIPR SGNVSFEIGVKPFLSNDASPVSLIIFTILFFALACLLSLNPSKIIDIVGKFLTPIKLT FIGLLVAVALIRPIGTIQAPSKGYTSQAFFKGFQEGYLTLDALVAFVFGIIIVNALKE QGASTKKQLIVVCAKAAAIAAVLLAVMYTALSYMGASSVEELGILENGAEVLAKVSSY YFGSYGSILLGLMITVACLTTSVGLITACSSFFHELFPNISYKKIAVVLSVFSTLVAN IGLTQLIKVSMPVLLTMYPIAISLIFLTFLHSVFKGKTEVYQGSLLFAFIISLFDGLK AAGIKIEVVNRIFTQILPMYNIGLGWLIPAIAGGICGYILSIFRTKTS*" /label="brnQ CDS" gene complement(2378275..2379597) /gene="brnQ" /locus_tag="BSU_26690" /old_locus_tag="BSU26690" /label="brnQ gene" CDS complement(2379762..2380094) /gene="azlD" /locus_tag="BSU_26700" /old_locus_tag="BSU26700" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9287000, 25645558" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9287000, 25645558; Product type t: transporter" /codon_start=1 /transl_table=11 /product="branched-chain amino acid / methionine exporter" /protein_id="NP_390547.1" /db_xref="EnsemblGenomes-Gn:BSU26700" /db_xref="EnsemblGenomes-Tr:CAB14611" /db_xref="GOA:O07923" /db_xref="InterPro:IPR008407" /db_xref="SubtiList:BG11916" /db_xref="UniProtKB/Swiss-Prot:O07923" /translation="MTMTMTQQMITIAMVVLGTMLTRFLPFMIFPSGKPTPKYVQYLG KVLPSAVIGLLVIYCLKDVSLLSGSHGIPELVGAAAVVLLHLWKKNMLLSIAGGTVVY MVLVQLVF*" /label="azlD CDS" gene complement(2379762..2380094) /gene="azlD" /locus_tag="BSU_26700" /old_locus_tag="BSU26700" /label="azlD gene" CDS complement(2380091..2380855) /gene="azlC" /locus_tag="BSU_26710" /old_locus_tag="BSU26710" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9287000, 15849754, 16850406, 25645558" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9287000, 15849754, 16850406, 25645558; Product type t: transporter" /codon_start=1 /transl_table=11 /product="branched-chain amino acid / methionine exporter" /protein_id="NP_390548.1" /db_xref="EnsemblGenomes-Gn:BSU26710" /db_xref="EnsemblGenomes-Tr:CAB14612" /db_xref="GOA:O07942" /db_xref="InterPro:IPR004471" /db_xref="InterPro:IPR011606" /db_xref="SubtiList:BG11915" /db_xref="UniProtKB/Swiss-Prot:O07942" /translation="MNKNKESLHLSSPAINTHMNKRSQIWAAFRSAFPYTIPIFAGFL FLGIAYGIFMHSLGFSAIYPIIMSFMIFAGSMEFVAANFLLGAFNPMNALFLTLMVNA RHLFYGISMLDKYRGTGKKKLYLIFGMCDESFSINYTANVPANVDKGWFMFFVTLLNH LYWVAGAAIGGIFGSYVKFNTEGLDFVMTALFIVIFIEQWMKEKKHYSALTGLGLSVA SLILFGGNQFIIPAMLAILGVLTVLRKPLEKAEVSV*" /label="azlC CDS" gene complement(2380091..2380855) /gene="azlC" /locus_tag="BSU_26710" /old_locus_tag="BSU26710" /label="azlC gene" CDS complement(2380868..2381341) /gene="azlB" /locus_tag="BSU_26720" /old_locus_tag="BSU26720" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9023181, 9287000, 26473603" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9023181, 9287000, 26473603; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of the azlBCD operon" /protein_id="NP_390549.1" /db_xref="EnsemblGenomes-Gn:BSU26720" /db_xref="EnsemblGenomes-Tr:CAB14613" /db_xref="GOA:O07920" /db_xref="InterPro:IPR000485" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR019885" /db_xref="InterPro:IPR019887" /db_xref="InterPro:IPR019888" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11914" /db_xref="UniProtKB/Swiss-Prot:O07920" /translation="MGIMLDETDKAILRDLQEDASISNLNLSKKIGLSPSACLARTKN LVEAGIIKKFTTIVDEKKLGIEVTALALINLSPLNRETIHSFLEDINKFPQVQECYTL TGSHDYMLKIVAKDMESYRNFIIDSLMQNPAISGVDTSIVMSTEKRTVSVPIDEM*" /label="azlB CDS" gene complement(2380868..2381341) /gene="azlB" /locus_tag="BSU_26720" /old_locus_tag="BSU26720" /label="azlB gene" CDS complement(2381675..2381950) /gene="yrdF" /locus_tag="BSU_26730" /old_locus_tag="BSU26730" /function="16.8: Protect" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative ribonuclease inhibitor" /protein_id="NP_390550.1" /db_xref="EnsemblGenomes-Gn:BSU26730" /db_xref="EnsemblGenomes-Tr:CAB14614" /db_xref="GOA:O07938" /db_xref="InterPro:IPR000468" /db_xref="InterPro:IPR035905" /db_xref="SubtiList:BG12285" /db_xref="UniProtKB/Swiss-Prot:O07938" /translation="MRKIIIDGRDFENIEVLHDDLKDKLDFPDYYGRNLDALWDCLTG WVDLPLTLVLKNFEFSNTFLGSYADDVLEVIQEAQEELKDEFKIIIE*" /label="yrdF CDS" gene complement(2381675..2381950) /gene="yrdF" /locus_tag="BSU_26730" /old_locus_tag="BSU26730" /label="yrdF gene" misc_feature complement(2381962..2381981) /Source="Nicolas_upshift_promotors" /id="U2055" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.881118881118881" /psig="0.972027972027972" /xcortree=3056 /SigmaFactorBS="ttttcagcctcatttggacaaacagctgttacatagtaaacg tttgtTAAGATAAAATAATGGAGGGcatagtttctaatgagaaaaataataatagatg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2381968) /Source="Nicolas_upshifts" /id="U2055" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.881118881118881" /psig="0.972027972027972" /xcortree=3056 /SigmaFactorBS="ttttcagcctcatttggacaaacagctgttacatagtaaacg tttgtTAAGATAAAATAATGGAGGGcatagtttctaatgagaaaaataataatagatg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2382036..2382221) /Source="Nicolas_S_feature" /locus_tag="new_2730921_2731106_c" /HighExp="BT, S4, S8, S3, S5, S7, S6, LoTm, B36, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.977" /TUlongSig="NA" /TUlongPSig="NA" /label="S1002" CDS complement(2382222..2383454) /gene="cypA" /locus_tag="BSU_26740" /old_locus_tag="BSU26740" /EC_number="1.14.-.-" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9778370, 12354229, 28898812" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9778370, 12354229, 28898812; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome P450" /protein_id="NP_390551.1" /db_xref="EnsemblGenomes-Gn:BSU26740" /db_xref="EnsemblGenomes-Tr:CAB14615" /db_xref="GOA:O08469" /db_xref="InterPro:IPR001128" /db_xref="InterPro:IPR002397" /db_xref="InterPro:IPR017972" /db_xref="InterPro:IPR036396" /db_xref="SubtiList:BG11929" /db_xref="UniProtKB/Swiss-Prot:O08469" /translation="MSSKEKKSVTILTESQLSSRAFKDEAYEFYKELRKSQALYPLSL GALGKGWLISRYDDAIHLLKNEKLKKNYENVFTAKEKRPALLKNEETLTKHMLNSDPP DHNRLRTLVQKAFTHRMILQLEDKIQHIADSLLDKVQPNKFMNLVDDYAFPLPIIVIS EMLGIPLEDRQKFRVWSQAIIDFSDAPERLQENDHLLGEFVEYLESLVRKKRREPAGD LISALIQAESEGTQLSTEELYSMIMLLIVAGHETTVNLITNMTYALMCHHDQLEKLRQ QPDLMNSAIEEALRFHSPVELTTIRWTAEPFILHGQEIKRKDVIIISLASANRDEKIF PNADIFDIERKNNRHIAFGHGNHFCLGAQLARLEAKIAISTLLRRCPNIQLKGEKKQM KWKGNFLMRALEELPISF*" /label="cypA CDS" gene complement(2382222..2383454) /gene="cypA" /locus_tag="BSU_26740" /old_locus_tag="BSU26740" /label="cypA gene" CDS complement(2383504..2383662) /gene="yrdDc" /locus_tag="BSU_26748" /old_locus_tag="BSU26748" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein; C-terminal part of YrdD" /db_xref="PSEUDO:CAX52669.1" /translation="MEVLGVSPFYQGKSLGSKMINDCLISFISKCGDGILALIMNTDL NGSFYKSS*" /label="yrdDc CDS" gene complement(2383504..2383662) /gene="yrdDc" /locus_tag="BSU_26748" /old_locus_tag="BSU26748" /pseudo /label="yrdDc gene" CDS complement(2383659..2383862) /gene="yrdDm" /locus_tag="BSU_26749" /old_locus_tag="BSU26749" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein; internal part of YrdD" /db_xref="SubtiList:BG12284" /translation="MHKVLTRAYFKKHFFFVGIQNGEMVVAALLKHRDKPDIKLDRLY SSRGDNINQNGAKKFSKSLKEPA*" /label="yrdDm CDS" gene complement(2383659..2383862) /gene="yrdDm" /locus_tag="BSU_26749" /old_locus_tag="BSU26749" /pseudo /label="yrdDm gene" promotor_-10 complement(2383823..2383841) /Source="Nicolas_upshift_promotors" /id="U2056" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=1116 /SigmaFactorBS="gtaaaacgcgaaaaaaagatcattcatttatttttgaaaTGC ATAaagtactgacaagaGCATATTTTAAAAAGCATTtcttttttgttggcattcagaa t" /listShort="yrdD, yrdD, cypA, S1002" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2383840) /Source="Nicolas_upshifts" /id="U2056" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=1116 /SigmaFactorBS="gtaaaacgcgaaaaaaagatcattcatttatttttgaaaTGC ATAaagtactgacaagaGCATATTTTAAAAAGCATTtcttttttgttggcattcagaa t" /listShort="yrdD, yrdD, cypA, S1002" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2383847..2383996) /gene="yrdDn" /locus_tag="BSU_26750" /old_locus_tag="BSU26750" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein; N-terminal part of YrdD" /db_xref="SubtiList:BG14036" /translation="MFLYRQARADEVSKVAKLFHQSFNQYPFMDLLVKREKKIIHLFL KCIKY*" /label="yrdDn CDS" gene complement(2383847..2383996) /gene="yrdDn" /locus_tag="BSU_26750" /old_locus_tag="BSU26750" /pseudo /label="yrdDn gene" promotor_-35 complement(2383856..2383861) /Source="Nicolas_upshift_promotors" /id="U2056" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=1116 /SigmaFactorBS="gtaaaacgcgaaaaaaagatcattcatttatttttgaaaTGC ATAaagtactgacaagaGCATATTTTAAAAAGCATTtcttttttgttggcattcagaa t" /listShort="yrdD, yrdD, cypA, S1002" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2384080) /Source="Nicolas_upshifts" /id="D1367" /incds=0 /nref=140 /ntot=216 /MaxReadThrough="2.2276" /MaxDrop="4.5127" /score="5.01317133" /energy="-16.7" /TU="NA" /idTUdmin="U2057" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2384095..2384658) /gene="yrdC" /locus_tag="BSU_26760" /old_locus_tag="BSU26760" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_390553.1" /db_xref="EnsemblGenomes-Gn:BSU26760" /db_xref="EnsemblGenomes-Tr:CAB14617" /db_xref="GOA:O07081" /db_xref="InterPro:IPR000868" /db_xref="InterPro:IPR036380" /db_xref="SubtiList:BG12283" /db_xref="UniProtKB/Swiss-Prot:O07081" /translation="MEEKKALIIVDVQKAFDDKKWGERNNVKAEENISKILELWREKG WTVIYIQHTSDKPHSLFHPKNEGFAIKEIVKPMDEEVIITKTVNSSFIGTNLEEFLKL NEITTVVITGLTTPHCVSTTTRMSGNLGFDTYLISDATAAFGMRDQNDTYYDAATIHN ISLATLHDEFATILTTDQLINDFIKTH*" /label="yrdC CDS" gene complement(2384095..2384658) /gene="yrdC" /locus_tag="BSU_26760" /old_locus_tag="BSU26760" /label="yrdC gene" downshifts 2384576 /Source="Nicolas_upshifts" /id="D1368" /incds=1 /nref=44 /ntot=194 /MaxReadThrough="1.72227" /MaxDrop="3.37915" /score="14.6499034" /energy="-6.6" /TU="NA" /idTUdmin="U2060" /TUdmin="-4488" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2384688..2384707) /Source="Nicolas_upshift_promotors" /id="U2057" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.856143856143856" /psig="0.997002997002997" /xcortree=2342 /SigmaFactorBS="ggcgctcatttgaaattcatcattaaaCAATTGTAcaaaagt aaaatttGTATTTAGAATGTAGTAATAaatagaaattctacgtaggagggtatcttgt g" /listShort="yrdC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2384696) /Source="Nicolas_upshifts" /id="U2057" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.856143856143856" /psig="0.997002997002997" /xcortree=2342 /SigmaFactorBS="ggcgctcatttgaaattcatcattaaaCAATTGTAcaaaagt aaaatttGTATTTAGAATGTAGTAATAaatagaaattctacgtaggagggtatcttgt g" /listShort="yrdC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2384722..2384729) /Source="Nicolas_upshift_promotors" /id="U2057" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.856143856143856" /psig="0.997002997002997" /xcortree=2342 /SigmaFactorBS="ggcgctcatttgaaattcatcattaaaCAATTGTAcaaaagt aaaatttGTATTTAGAATGTAGTAATAaatagaaattctacgtaggagggtatcttgt g" /listShort="yrdC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2384887..2385258) /gene="yrdB" /locus_tag="BSU_26770" /old_locus_tag="BSU26770" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390554.1" /db_xref="EnsemblGenomes-Gn:BSU26770" /db_xref="EnsemblGenomes-Tr:CAB14618" /db_xref="GOA:O07080" /db_xref="InterPro:IPR021214" /db_xref="SubtiList:BG12282" /db_xref="UniProtKB/Swiss-Prot:O07080" /translation="MEKLNQTNLLLRFTLEIAALISLGVYAWISFNGYFKYVLTLVLP IAVMIVWSVFAVPHDPSRSGQTVIAVNGVTRLVIELLIFAMAVAALYFSYLKPVSIVF LCLIILHYIISAERIKWLLNQ*" /label="yrdB CDS" gene complement(2384887..2385258) /gene="yrdB" /locus_tag="BSU_26770" /old_locus_tag="BSU26770" /label="yrdB gene" S_feature complement(2385259..2385488) /Source="Nicolas_S_feature" /locus_tag="new_2734144_2734373_c" /HighExp="BMM, GM 120, GM 90, SMM, MG 150, GM 60, MG 120, M9-tran, Glu, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.48162700000000003" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1003" promotor_-10 complement(2385470..2385489) /Source="Nicolas_upshift_promotors" /id="U2058" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=3041 /SigmaFactorBS="gtataatctttacttcgttcgacaaattctgcaaatTGTAGA CAacttcctgattatTTGGATAATTAACTGAATAGgaggggaaaagttgtcatatttc a" /listShort="S1003, yrdB" /listLong="yrdC" /label="promotor_-10" upshifts complement(2385486) /Source="Nicolas_upshifts" /id="U2058" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=3041 /SigmaFactorBS="gtataatctttacttcgttcgacaaattctgcaaatTGTAGA CAacttcctgattatTTGGATAATTAACTGAATAGgaggggaaaagttgtcatatttc a" /listShort="S1003, yrdB" /listLong="yrdC" /label="upshifts" promotor_-35 complement(2385503..2385510) /Source="Nicolas_upshift_promotors" /id="U2058" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=3041 /SigmaFactorBS="gtataatctttacttcgttcgacaaattctgcaaatTGTAGA CAacttcctgattatTTGGATAATTAACTGAATAGgaggggaaaagttgtcatatttc a" /listShort="S1003, yrdB" /listLong="yrdC" /label="promotor_-35" downshifts complement(2386054) /Source="Nicolas_upshifts" /id="D1369" /incds=0 /nref=174 /ntot=248 /MaxReadThrough="2.42722" /MaxDrop="5.81863" /score="7.90390368" /energy="-10.3" /TU="NA" /idTUdmin="U2059" /TUdmin=6 /isTUend="TRUE" /label="downshifts" CDS complement(2386068..2386571) /gene="yrdA" /locus_tag="BSU_26780" /old_locus_tag="BSU26780" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390555.1" /db_xref="EnsemblGenomes-Gn:BSU26780" /db_xref="EnsemblGenomes-Tr:CAB14619" /db_xref="GOA:O07079" /db_xref="InterPro:IPR007837" /db_xref="InterPro:IPR034660" /db_xref="SubtiList:BG12281" /db_xref="UniProtKB/Swiss-Prot:O07079" /translation="MFQTLDHFLKSWEFEADATQKLLNSLTDESLKQEITSQNWTLGR IAWHTVAAIGIITSNTDLTFQAPAEDYPVPTSAQFIADSYHQASNAFVQALKTQWTDH TLQERINFIGQQMPNGSLLMFLIQHQNHHRGQMTVLMRQAGLTVPGIYGPAKEEWAKF GLEAPKM*" /label="yrdA CDS" gene complement(2386068..2386571) /gene="yrdA" /locus_tag="BSU_26780" /old_locus_tag="BSU26780" /label="yrdA gene" S_feature complement(2386572..2386796) /Source="Nicolas_S_feature" /locus_tag="new_2735457_2735681_c" /HighExp="Etha, Lbstat, M0t90, M40t90, LoTm, M9-stat, Gly, S2, T0.30H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1004" CDS complement(2386797..2387651) /gene="aadK" /locus_tag="BSU_26790" /old_locus_tag="BSU26790" /EC_number="2.7.7.-" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8293959" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8293959; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="aminoglycoside 6-adenylyltransferase" /protein_id="NP_390556.1" /db_xref="EnsemblGenomes-Gn:BSU26790" /db_xref="EnsemblGenomes-Tr:CAB14620" /db_xref="GOA:P17585" /db_xref="InterPro:IPR007530" /db_xref="PDB:2PBE" /db_xref="SubtiList:BG11037" /db_xref="UniProtKB/Swiss-Prot:P17585" /translation="MRSEQEMMDIFLDFALNDERIRLVTLEGSRTNRNIPPDNFQDYD ISYFVTDVESFKENDQWLEIFGKRIMMQKPEDMELFPPELGNWFSYIILFEDGNKLDL TLIPIREAEDYFANNDGLVKVLLDKDSFINYKVTPNDRQYWIKRPTAREFDDCCNEFW MVSTYVVKGLARNEILFAIDHLNEIVRPNLLRMMAWHIASQKGYSFSMGKNYKFMKRY LSNKEWEELMSTYSVNGYQEMWKSLFTCYALFRKYSKAVSEGLAYKYPDYDEGITKYT EGIYCSVK*" /label="aadK CDS" gene complement(2386797..2387651) /gene="aadK" /locus_tag="BSU_26790" /old_locus_tag="BSU26790" /label="aadK gene" S_feature complement(2387652..2387754) /Source="Nicolas_S_feature" /locus_tag="new_2736537_2736639_c" /HighExp="M9-stat, T3.0H, T0.30H, T1.30H, T2.30H, Lbtran, T3.30H, T1.0H, M0t90, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1005" promotor_-10 complement(2387735..2387754) /Source="Nicolas_upshift_promotors" /id="U2059" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.909090909090909" /psig="0.997002997002997" /xcortree=3219 /SigmaFactorBS="gttgatatctgattttgagatgtcttgcatcttaatattgAA TGatatataggagaacATCATGTAAAATAAAGCTTAgaagaatacatcacattcaaga g" /listShort="S1005, aadK, S1004, yrdA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2387752) /Source="Nicolas_upshifts" /id="U2059" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.909090909090909" /psig="0.997002997002997" /xcortree=3219 /SigmaFactorBS="gttgatatctgattttgagatgtcttgcatcttaatattgAA TGatatataggagaacATCATGTAAAATAAAGCTTAgaagaatacatcacattcaaga g" /listShort="S1005, aadK, S1004, yrdA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2387769..2387772) /Source="Nicolas_upshift_promotors" /id="U2059" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.909090909090909" /psig="0.997002997002997" /xcortree=3219 /SigmaFactorBS="gttgatatctgattttgagatgtcttgcatcttaatattgAA TGatatataggagaacATCATGTAAAATAAAGCTTAgaagaatacatcacattcaaga g" /listShort="S1005, aadK, S1004, yrdA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2387923..2387930 /Source="Nicolas_upshift_promotors" /id="U2060" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.723276723276723" /psig="0.894105894105894" /xcortree=2930 /SigmaFactorBS="atcgacatgttaactggtatgagaGATTGACAaaaagaagga aaaCGATATATTTAAGCGAATACgagtttttgagtaaattttaaaatgacactttttt c" /listShort="S1006, yrpB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2387944..2387963 /Source="Nicolas_upshift_promotors" /id="U2060" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.723276723276723" /psig="0.894105894105894" /xcortree=2930 /SigmaFactorBS="atcgacatgttaactggtatgagaGATTGACAaaaagaagga aaaCGATATATTTAAGCGAATACgagtttttgagtaaattttaaaatgacactttttt c" /listShort="S1006, yrpB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2387959 /Source="Nicolas_upshifts" /id="U2060" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.723276723276723" /psig="0.894105894105894" /xcortree=2930 /SigmaFactorBS="atcgacatgttaactggtatgagaGATTGACAaaaagaagga aaaCGATATATTTAAGCGAATACgagtttttgagtaaattttaaaatgacactttttt c" /listShort="S1006, yrpB" /GFF_Attribute="listLong" /label="upshifts" S_feature 2387964..2388029 /Source="Nicolas_S_feature" /locus_tag="new_2736849_2736914" /HighExp="LoTm, BC, S1, S2, C90, T4.0H, HiOs, T5.0H, T3.30H, SMMPr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.894" /TUlongSig="NA" /TUlongPSig="NA" /label="S1006" CDS 2388030..2389073 /gene="yrpB" /locus_tag="BSU_26800" /old_locus_tag="BSU26800" /EC_number="1.13.12.-" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9501443; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative anionic nitroalkane monoxygenase" /protein_id="NP_390557.1" /db_xref="EnsemblGenomes-Gn:BSU26800" /db_xref="EnsemblGenomes-Tr:CAB14621" /db_xref="GOA:O05413" /db_xref="InterPro:IPR004136" /db_xref="InterPro:IPR013785" /db_xref="SubtiList:BG12305" /db_xref="UniProtKB/Swiss-Prot:O05413" /translation="MNEFMKKFSLTKPIIQAPMAGGITKPRLASAVSNQGALGSLASG YLTPDLLEQQIKEIFELTDAPFQINVFVPLGLEMPPKDQIKKWKENIPLANQVNQFTS VQEEWDDFYQKIDLILKYKVKACSFTFDLPPEDAVKELKTAGCCLIGTASTVEEALLM EERGMDIVVLQGSEAGGHRGAFLPSKGESAVGLMALIPQAADALSVPVIAAGGMIDHR GVKAALTLGAQGVQIGSAFLICHESNAHPVHKQKILEANEADTKLTTLFSGKEARGIV NKWMEENEQFETQTLPYPYQNTLTKAMRQKASLQNNHDQMSLWAGQGIRSLTEEISVK QLLNQLCQEDIKI*" /label="yrpB CDS" gene 2388030..2389073 /gene="yrpB" /locus_tag="BSU_26800" /old_locus_tag="BSU26800" /label="yrpB gene" downshifts 2389071 /Source="Nicolas_upshifts" /id="D1370" /incds=0 /nref=22 /ntot=198 /MaxReadThrough="1.3622" /MaxDrop="5.04821" /score="14.6499034" /energy="-6.6" /TU="NA" /idTUdmin="U2060" /TUdmin=7 /isTUend="TRUE" /label="downshifts" promotor_-35 2389358..2389365 /Source="Nicolas_upshift_promotors" /id="U2061" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95904095904096" /psig=1 /xcortree=2015 /SigmaFactorBS="atcgatagctcccatattaaatttgaatagtaaaatggttct ttttCGTTTGATtcagatgatataaAGTCATATGATAAAAAAAGAatgagacagaaag c" /listShort="yrpC" /listLong="yrpD, S1007" /label="promotor_-35" upshifts 2389372 /Source="Nicolas_upshifts" /id="U2061" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95904095904096" /psig=1 /xcortree=2015 /SigmaFactorBS="atcgatagctcccatattaaatttgaatagtaaaatggttct ttttCGTTTGATtcagatgatataaAGTCATATGATAAAAAAAGAatgagacagaaag c" /listShort="yrpC" /listLong="yrpD, S1007" /label="upshifts" promotor_-10 2389379..2389398 /Source="Nicolas_upshift_promotors" /id="U2061" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95904095904096" /psig=1 /xcortree=2015 /SigmaFactorBS="atcgatagctcccatattaaatttgaatagtaaaatggttct ttttCGTTTGATtcagatgatataaAGTCATATGATAAAAAAAGAatgagacagaaag c" /listShort="yrpC" /listLong="yrpD, S1007" /label="promotor_-10" CDS 2389423..2390220 /gene="murI" /locus_tag="BSU_26810" /old_locus_tag="BSU26810" /EC_number="5.1.1.3" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12829290, 15212785, 15347750, 17720142, 25777674" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12829290, 15212785, 15347750, 17720142, 25777674; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamate racemase" /protein_id="NP_390558.1" /db_xref="EnsemblGenomes-Gn:BSU26810" /db_xref="EnsemblGenomes-Tr:CAB14622" /db_xref="GOA:O05412" /db_xref="InterPro:IPR001920" /db_xref="InterPro:IPR004391" /db_xref="InterPro:IPR015942" /db_xref="InterPro:IPR018187" /db_xref="SubtiList:BG12306" /db_xref="UniProtKB/Swiss-Prot:O05412" /translation="MKIGFFDSGIGGMTVLYEAIKVLPYEDYIFYADTLNVPYGEKSK GKVKEYIFNAAEFLASQNIKALVIACNTATSIAIEDLRRNFDFPIIGIEPAVKPAINK CTEERKRVLVVATNLTLKEEKFHNLVKEIDHHDLVDCLALPGLVEFAENFDFSEDKII KYLKNELSSFDLKQYGTIVLGCTHFPFFKNSFEKLFGIKVDMISGSVGTAKQLKKVLA DRNQLGKGSGSITFFNSGHKIVDQEVISKYKRLFEILDETQRSHVGH*" /label="murI CDS" gene 2389423..2390220 /gene="murI" /locus_tag="BSU_26810" /old_locus_tag="BSU26810" /label="murI gene" promotor_-35 2390526..2390530 /Source="Nicolas_upshift_promotors" /id="U2062" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.304695304695305" /psig="0.997002997002997" /xcortree=3238 /SigmaFactorBS="gtgtaaattctgtatctatgtgcatgtttattATGGAattat tttcataaTGTTTTATAATACAAGATGAtagcgttttctaattataatgataggggga a" /listShort="yrpD, S1007, S1008, S1009, S1010" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2390544..2390563 /Source="Nicolas_upshift_promotors" /id="U2062" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.304695304695305" /psig="0.997002997002997" /xcortree=3238 /SigmaFactorBS="gtgtaaattctgtatctatgtgcatgtttattATGGAattat tttcataaTGTTTTATAATACAAGATGAtagcgttttctaattataatgataggggga a" /listShort="yrpD, S1007, S1008, S1009, S1010" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2390554 /Source="Nicolas_upshifts" /id="U2062" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.304695304695305" /psig="0.997002997002997" /xcortree=3238 /SigmaFactorBS="gtgtaaattctgtatctatgtgcatgtttattATGGAattat tttcataaTGTTTTATAATACAAGATGAtagcgttttctaattataatgataggggga a" /listShort="yrpD, S1007, S1008, S1009, S1010" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2390578..2390592) /Source="Nicolas_upshift_promotors" /id="U2063" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.921078921078921" /psig="0.070929070929071" /xcortree=302 /SigmaFactorBS="caaaaagcacggttgccgtaagcgcacccgcaagcagacctt ttttcATCATcattatttCCCCCTATCATTATAattagaaaacgctatcatcttgtat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2390592) /Source="Nicolas_upshifts" /id="U2063" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.921078921078921" /psig="0.070929070929071" /xcortree=302 /SigmaFactorBS="caaaaagcacggttgccgtaagcgcacccgcaagcagacctt ttttcATCATcattatttCCCCCTATCATTATAattagaaaacgctatcatcttgtat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2390601..2390605) /Source="Nicolas_upshift_promotors" /id="U2063" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.921078921078921" /psig="0.070929070929071" /xcortree=302 /SigmaFactorBS="caaaaagcacggttgccgtaagcgcacccgcaagcagacctt ttttcATCATcattatttCCCCCTATCATTATAattagaaaacgctatcatcttgtat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2390601..2391308 /gene="yrpD" /locus_tag="BSU_26820" /old_locus_tag="BSU26820" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 25355936; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_390559.1" /db_xref="EnsemblGenomes-Gn:BSU26820" /db_xref="EnsemblGenomes-Tr:CAB14623" /db_xref="InterPro:IPR029143" /db_xref="SubtiList:BG12307" /db_xref="UniProtKB/Swiss-Prot:O05411" /translation="MMKKGLLAGALTATVLFGTCAVDVPGIISPKTAEAASQLTDGIG GRAYLNSNGAILVTKIQLPSSTQVSNGTAYIYSGFSGGTESDIGFQYSDKYNVWKPYM KVGSKGQDQVQYLEGGSQFTNTKGFRPGSTVQLTIYKNLNGNTRATYWGTNNAGYNGR LISEISKTNVGSISKWKALATVATTGSRQSIKSNFSTSFTNITIDNKAITPVIDTQDF AKVTVSGNSVSLSVVKN*" /label="yrpD CDS" gene 2390601..2391308 /gene="yrpD" /locus_tag="BSU_26820" /old_locus_tag="BSU26820" /label="yrpD gene" downshifts 2391308 /Source="Nicolas_upshifts" /id="D1371" /incds=0 /nref=4 /ntot=168 /MaxReadThrough="5.98921" /MaxDrop="2.677" /score="15.7112026" /energy="-8.2" /TU="U2062" /idTUdmin="U2064" /TUdmin="-660" /isTUend="FALSE" /label="downshifts" S_feature 2391353..2391526 /Source="Nicolas_S_feature" /locus_tag="new_2740238_2740411" /HighExp="Lbstat, M0t90, M40t90, BT, S0, ferm, S2, M9-stat, Lbtran, T1.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="SigA" /TUlongPSig=1 /label="S1007" promotor_-35 2391508..2391509 /Source="Nicolas_upshift_promotors" /id="U2064" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.591408591408591" /psig="0.861138861138861" /xcortree=1974 /SigmaFactorBS="ccccttctgaacctgttccatttgctcaacgcaaaaggtgTG catcactgtcttaaaAATGTTAAAACAAATAGCAGatggtgcactttatttttagatg a" /listShort="S1008, S1009" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2391525..2391544 /Source="Nicolas_upshift_promotors" /id="U2064" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.591408591408591" /psig="0.861138861138861" /xcortree=1974 /SigmaFactorBS="ccccttctgaacctgttccatttgctcaacgcaaaaggtgTG catcactgtcttaaaAATGTTAAAACAAATAGCAGatggtgcactttatttttagatg a" /listShort="S1008, S1009" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2391528..2391856 /Source="Nicolas_S_feature" /locus_tag="new_2740413_2740741" /HighExp="Lbstat, M0t90, BT, M40t90, S2, S0, ferm, T2.0H, M9-stat, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99711000000000005" /TUshortSig="SigA, SigA" /TUshortPSig="0.861, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1008" upshifts 2391528 /Source="Nicolas_upshifts" /id="U2064" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.591408591408591" /psig="0.861138861138861" /xcortree=1974 /SigmaFactorBS="ccccttctgaacctgttccatttgctcaacgcaaaaggtgTG catcactgtcttaaaAATGTTAAAACAAATAGCAGatggtgcactttatttttagatg a" /listShort="S1008, S1009" /GFF_Attribute="listLong" /label="upshifts" CDS 2391632..2391793 /locus_tag="BSU_26829" /old_locus_tag="BSU26829" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="PSEUDO:SOX90581.1" /translation="MYFHKRGMASYSSIASGRLANDWPRTTHHFETDSFQNHKYDPIT NKDQLAVQP*" /label="hypothetical protein CDS" gene 2391632..2391793 /locus_tag="BSU_26829" /old_locus_tag="BSU26829" /pseudo /label="gene" promotor_-35 2391822..2391831 /Source="Nicolas_upshift_promotors" /id="U2065" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1413 /SigmaFactorBS="atttttacatcaattaaactagcaTCACTATCGAataagctc gatcTGCATATCATGTACTATCCTcttttaaggaaggtgatgttatgaggtcatttcc a" /listShort="S1009, S1010" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2391844..2391863 /Source="Nicolas_upshift_promotors" /id="U2065" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1413 /SigmaFactorBS="atttttacatcaattaaactagcaTCACTATCGAataagctc gatcTGCATATCATGTACTATCCTcttttaaggaaggtgatgttatgaggtcatttcc a" /listShort="S1009, S1010" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2391858..2392009 /Source="Nicolas_S_feature" /locus_tag="new_2740743_2740894" /HighExp="BT, S8, B36, S7, Lbstat, G/S, Pyr, M0t90, B60, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.94474599999999997" /TUshortSig="SigK, SigA, SigA" /TUshortPSig="1, 0.861, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1009" upshifts 2391858 /Source="Nicolas_upshifts" /id="U2065" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1413 /SigmaFactorBS="atttttacatcaattaaactagcaTCACTATCGAataagctc gatcTGCATATCATGTACTATCCTcttttaaggaaggtgatgttatgaggtcatttcc a" /listShort="S1009, S1010" /GFF_Attribute="listLong" /label="upshifts" CDS 2391884..2391961 /gene="yrpDX" /locus_tag="BSU_26826" /old_locus_tag="BSU26826" /experiment="publication(s) with functional evidences, PMID:20709900" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20709900" /codon_start=1 /transl_table=11 /product="expressed polypeptide of unknown function" /protein_id="YP_009513985.1" /db_xref="EnsemblGenomes-Gn:BSU26826" /db_xref="EnsemblGenomes-Tr:CCQ48602" /db_xref="GOA:L8E9J8" /db_xref="InterPro:IPR010070" /db_xref="UniProtKB/TrEMBL:L8E9J8" /translation="MRSFPLIVVLFILLIIVGTSFFGGY*" /label="yrpDX CDS" gene 2391884..2391961 /gene="yrpDX" /locus_tag="BSU_26826" /old_locus_tag="BSU26826" /label="yrpDX gene" downshifts 2391966 /Source="Nicolas_upshifts" /id="D1372" /incds=0 /nref=23 /ntot=198 /MaxReadThrough="3.86249" /MaxDrop="4.0885" /score="28.4802594" /energy="-18.1" /TU="U2062,U2065" /idTUdmin="U2064" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" S_feature 2392011..2392208 /Source="Nicolas_S_feature" /locus_tag="new_2740896_2741093" /HighExp="BT, B36, S8, Lbstat, G/S, Pyr, Diami, S7, dia15, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA" /TUshortPSig="1, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1010" S_feature complement(2392200..2392471) /Source="Nicolas_S_feature" /locus_tag="new_2741085_2741356_c" /HighExp="Heat, BMM, Etha, S2, S3, S4, B36, S5, B60, T0.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.40965600000000002" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1011" downshifts complement(2392242) /Source="Nicolas_upshifts" /id="D1373" /incds=0 /nref=37 /ntot=78 /MaxReadThrough="2.30607" /MaxDrop="6.9537" /score="19.9821634" /energy="-15.5" /TU="NA" /idTUdmin="U2066" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2392248..2392409) /locus_tag="BSU_26827" /old_locus_tag="BSU26827" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513986.1" /translation="MGKKLIETIQYPPYYCDVAYLESSHMKSRRNLFQNKKSLDVWQW ITLEIYWLI*" /label="hypothetical protein CDS" gene complement(2392248..2392409) /locus_tag="BSU_26827" /old_locus_tag="BSU26827" /label="gene" CDS complement(2392472..2393227) /gene="zinT" /locus_tag="BSU_26830" /old_locus_tag="BSU26830" /function="16.14: Store" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12904577, 24128931; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="lipoprotein buffering protein for Zn2+ transport" /protein_id="NP_390560.1" /db_xref="EnsemblGenomes-Gn:BSU26830" /db_xref="EnsemblGenomes-Tr:CAB14624" /db_xref="GOA:O05410" /db_xref="InterPro:IPR012674" /db_xref="InterPro:IPR015304" /db_xref="SubtiList:BG12308" /db_xref="UniProtKB/Swiss-Prot:O05410" /translation="MNILFSKRLGILTIGSLLVLAGCQTSGSSAGESNQTTSSSAVEE DSSKTQEQTSDSHTHEHSHDHSHAHDEETEKIYEGYFKNSQVKDRLLSDWEGDWQSVY PYLQDGTLDEVFSYKSEHEGGKTAEEYKEYYKKGYQTDVDRIVIQKDTVTFFKNGKEY SGKYTYDGYEILTYDAGNRGVRYIFKLAKKAEGLPQYIQFSDHSIYPTKASHYHLYWG DDREALLDEVKNWPTYYPSKMDGHDIAHEMMAH*" /label="zinT CDS" gene complement(2392472..2393227) /gene="zinT" /locus_tag="BSU_26830" /old_locus_tag="BSU26830" /label="zinT gene" promotor_-10 complement(2393258..2393277) /Source="Nicolas_upshift_promotors" /id="U2066" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.54045954045954" /psig=1 /xcortree=666 /SigmaFactorBS="tttaaaataggccatccgcatgaagagcatttttccTTTGAT gtttgcaagagatgtATGTATAATAAATCGTAATGttttcgatttaataaaaaaggag t" /listShort="yrpE, S1011" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2393274) /Source="Nicolas_upshifts" /id="U2066" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.54045954045954" /psig=1 /xcortree=666 /SigmaFactorBS="tttaaaataggccatccgcatgaagagcatttttccTTTGAT gtttgcaagagatgtATGTATAATAAATCGTAATGttttcgatttaataaaaaaggag t" /listShort="yrpE, S1011" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2393293..2393298) /Source="Nicolas_upshift_promotors" /id="U2066" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.54045954045954" /psig=1 /xcortree=666 /SigmaFactorBS="tttaaaataggccatccgcatgaagagcatttttccTTTGAT gtttgcaagagatgtATGTATAATAAATCGTAATGttttcgatttaataaaaaaggag t" /listShort="yrpE, S1011" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2393359..2393889) /gene="sigZ" /locus_tag="BSU_26840" /old_locus_tag="BSU26840" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11700344, 15019740, 17675383" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11700344, 15019740, 17675383; Product type r: regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase ECF(extracytoplasmic function)-type sigma factor (sigma-Z)" /protein_id="NP_390561.1" /db_xref="EnsemblGenomes-Gn:BSU26840" /db_xref="EnsemblGenomes-Tr:CAB14625" /db_xref="GOA:O05409" /db_xref="InterPro:IPR000838" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013249" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR014304" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11976" /db_xref="UniProtKB/Swiss-Prot:O05409" /translation="MNIEDLWDQFHQPLKTYISHRVNDQSIVDDLLQIVFMKIQVHLP NLIDEQKIDSWIYRITRNTIIDFYRTKKTSEILPDVLHFNDSAEEENFTKEATVCIRS TIKRLPEKYREALELTDFQGLSQKELSEKLGISYSGAKSRVQRGRGKLKQLLEGCCHI EADRYGNIVDFRILKE*" /label="sigZ CDS" gene complement(2393359..2393889) /gene="sigZ" /locus_tag="BSU_26840" /old_locus_tag="BSU26840" /label="sigZ gene" promotor_-10 complement(2393935..2393954) /Source="Nicolas_upshift_promotors" /id="U2067" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.519480519480519" /psig="0.996003996003996" /xcortree=1905 /SigmaFactorBS="acctctcctttatcattatttttggcaacagctgcaatacaa tTGATTCAAcaattgtttgctcTTTGTTACGATTAAAAAGACgaagcaaatgtaaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2393958) /Source="Nicolas_upshifts" /id="U2067" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.519480519480519" /psig="0.996003996003996" /xcortree=1905 /SigmaFactorBS="acctctcctttatcattatttttggcaacagctgcaatacaa tTGATTCAAcaattgtttgctcTTTGTTACGATTAAAAAGACgaagcaaatgtaaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2393968..2393975) /Source="Nicolas_upshift_promotors" /id="U2067" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.519480519480519" /psig="0.996003996003996" /xcortree=1905 /SigmaFactorBS="acctctcctttatcattatttttggcaacagctgcaatacaa tTGATTCAAcaattgtttgctcTTTGTTACGATTAAAAAGACgaagcaaatgtaaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2394024..2395004 /gene="yrpG" /locus_tag="BSU_26850" /old_locus_tag="BSU26850" /EC_number="1.1.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23990306, 25326299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aldo-keto reductase" /protein_id="NP_390562.2" /db_xref="EnsemblGenomes-Gn:BSU26850" /db_xref="EnsemblGenomes-Tr:CAB14626" /db_xref="GOA:O05408" /db_xref="InterPro:IPR023210" /db_xref="InterPro:IPR036812" /db_xref="SubtiList:BG12309" /db_xref="UniProtKB/Swiss-Prot:O05408" /translation="MEYTYLGRTGLRVSRLCLGTMNFGVDTDEKTAFRIMDEALDNGI QFFDTANIYGWGKNAGLTESIIGKWFAQGGQRREKVVLATKVYEPISDPNDGPNDMRG LSLYKIRRHLEGSLKRLQTDHIELYQMHHIDRRTPWDEIWEAFETQVRSGKVDYIGSS NFAGWHLVKAQAEAEKRRFMGLVTEQHKYSLLERTAEMEVLPAARDLGLGVVAWSPLA GGLLGGKALKSNAGTRTAKRADLIEKHRLQLEKFSDLCKELGEKEANVALAWVLANPV LTAPIIGPRTVEQLRDTIKAVEISLDKEILRMLNDIFPGPGGETPEAYAW*" /label="yrpG CDS" gene 2394024..2395004 /gene="yrpG" /locus_tag="BSU_26850" /old_locus_tag="BSU26850" /label="yrpG gene" CDS complement(2395278..2396594) /gene="yraO" /locus_tag="BSU_26860" /old_locus_tag="BSU26860" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11053381, 11566984, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative citrate transporter" /protein_id="NP_390563.1" /db_xref="EnsemblGenomes-Gn:BSU26860" /db_xref="EnsemblGenomes-Tr:CAB14627" /db_xref="GOA:O05407" /db_xref="InterPro:IPR004680" /db_xref="InterPro:IPR014738" /db_xref="SubtiList:BG12279" /db_xref="UniProtKB/Swiss-Prot:O05407" /translation="MLTILGFSMVTVFTILIMTKKVSPIVALTITPIVFALIGGFGKG IGDMILEGIQTVASSAALLLFAILFFGILIDAGLFDPLIEKILSIVKGDPVKIAIGSA VLAMLIALDGDGTTTYMITVSAMLPLYKRIGMNPMVMATLAMLSLSIVSGMTPWGGPA TRAISVLGLDPSDFFVPLLPTMLGGIACVIFLAFLMGRKERNRIGIVQLEPRHITKDS SQSYMAATLESEQLKRPRLIYLNLFLVISIMVFIVLGTKHPSVLFLIGFVLALTINYP NVKMQKERIAEHSGNAITVVLLVFSAGVFAGILSGTKMVDAIAGSLISIIPSSMGGFF PVIVALTSIPFTFVLSNDAYYFGMVPIFAEAASAYGIEPVEIARASIMGQPVHLMSPL VASTVLLVSMLKMDLGSFQRFAVKWAVITSLVITLLAIITGAITIL*" /label="yraO CDS" gene complement(2395278..2396594) /gene="yraO" /locus_tag="BSU_26860" /old_locus_tag="BSU26860" /label="yraO gene" S_feature complement(2396595..2396708) /Source="Nicolas_S_feature" /locus_tag="new_2745480_2745593_c" /HighExp="Lbtran, M40t90, Lbstat, HiTm, Mal, Gly, M0t90, S1, T1.0H, Fru" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1012" CDS complement(2396709..2397578) /gene="yraN" /locus_tag="BSU_26870" /old_locus_tag="BSU26870" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20011599; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (probes citrate or citrate-related metabolite)" /protein_id="NP_390564.1" /db_xref="EnsemblGenomes-Gn:BSU26870" /db_xref="EnsemblGenomes-Tr:CAB14628" /db_xref="GOA:O07906" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12278" /db_xref="UniProtKB/Swiss-Prot:O07906" /translation="MDEKDWILLKILHEEQSVTKTAERLFTSQPSITYRLKKIEEIFG IELFTKRHKGITFTAEGEHLVAYARRMLQELQDTKDHISNLSKEVQGHLRLGVSSNFA QYKLPKLLREFSTMYPNVQYSVQTGWSTDVMKLLDAGIVQVGILRGSHRWKGVEERLT REKLHIISKKPITIEQLPFLPFIKYKTDASLKTIIEDWMHTNLKQAPIIAMEVDRQET CKEMVKHGLGYSIAPEICLQESDHLYTMELYNAKGKPLMRDTWLMYDQKSLGIKLVKA FIDFLKGEQMVTI*" /label="yraN CDS" gene complement(2396709..2397578) /gene="yraN" /locus_tag="BSU_26870" /old_locus_tag="BSU26870" /label="yraN gene" promotor_-10 complement(2397601..2397620) /Source="Nicolas_upshift_promotors" /id="U2068" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.318681318681319" /psig="0.998001998001998" /xcortree=3210 /SigmaFactorBS="gtgtagaaggtaaaaaaataaaaataaaatataagtttTCTT AAtattcgataaaaaaACTTTTATAATTGTGAAAGAaggactagaaaggaagatgaaa a" /listShort="yraN, S1012, yraO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2397618) /Source="Nicolas_upshifts" /id="U2068" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.318681318681319" /psig="0.998001998001998" /xcortree=3210 /SigmaFactorBS="gtgtagaaggtaaaaaaataaaaataaaatataagtttTCTT AAtattcgataaaaaaACTTTTATAATTGTGAAAGAaggactagaaaggaagatgaaa a" /listShort="yraN, S1012, yraO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2397635..2397640) /Source="Nicolas_upshift_promotors" /id="U2068" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.318681318681319" /psig="0.998001998001998" /xcortree=3210 /SigmaFactorBS="gtgtagaaggtaaaaaaataaaaataaaatataagtttTCTT AAtattcgataaaaaaACTTTTATAATTGTGAAAGAaggactagaaaggaagatgaaa a" /listShort="yraN, S1012, yraO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2397685..2397686) /Source="Nicolas_upshift_promotors" /id="U2069" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.367632367632368" /psig="0.537462537462537" /xcortree=645 /SigmaFactorBS="ctctcatgattgttacattcgtcttgaccATcgtcatcatcc tcatcttaaAGGTAGTATTTtttatGTtttttagtgtagaaggtaaaaaaataaaaat a" /listShort="yraN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2397693) /Source="Nicolas_upshifts" /id="U2069" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.367632367632368" /psig="0.537462537462537" /xcortree=645 /SigmaFactorBS="ctctcatgattgttacattcgtcttgaccATcgtcatcatcc tcatcttaaAGGTAGTATTTtttatGTtttttagtgtagaaggtaaaaaaataaaaat a" /listShort="yraN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2397723..2397724) /Source="Nicolas_upshift_promotors" /id="U2069" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.367632367632368" /psig="0.537462537462537" /xcortree=645 /SigmaFactorBS="ctctcatgattgttacattcgtcttgaccATcgtcatcatcc tcatcttaaAGGTAGTATTTtttatGTtttttagtgtagaaggtaaaaaaataaaaat a" /listShort="yraN" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2397723..2398826 /gene="prpF" /locus_tag="BSU_26880" /old_locus_tag="BSU26880" /EC_number="5.3.3.7" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 11294638, 12473114, 14702315, 17567742; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aconitate isomerase" /protein_id="NP_390565.2" /db_xref="EnsemblGenomes-Gn:BSU26880" /db_xref="EnsemblGenomes-Tr:CAB14629" /db_xref="GOA:O07931" /db_xref="InterPro:IPR007400" /db_xref="SubtiList:BG12277" /db_xref="UniProtKB/Swiss-Prot:O07931" /translation="MVKTNVTIMRGGTSKGVFFHESAMPNNKNEWEPFLLDVMGSPDK RQIDGLGGGNSLTSKVAIIKKAYTSDIDVHYTFGQVSISEEKVDFKGNCGNISAAVGP FAIEEGLVKAKEPMTAVRILNTNTNKMIIAEVEVEDGQVKYDGDVTISGVPGSGSPIY LNFHDAAGSVTGHLLPTGNSSEFLDTSQGQIEVSIIDYANPLVFVEASSIGLDGTELA EEFTDLQLAQFEELRSIAAEKCGFASRFSATKLSPAVPKLAIVAKPEKYKDSTGAWHS SVEMDLHIRMMSMQKPHQALAVTGAICTTRALSVEGAIPARIAKNHSTKVRLAHSSGI IETMVEPTGIKIVRTARRIMDGTVYTHGDYQMM*" /label="prpF CDS" gene 2397723..2398826 /gene="prpF" /locus_tag="BSU_26880" /old_locus_tag="BSU26880" /label="prpF gene" misc_feature 2398716..2398735 /Source="Nicolas_upshift_promotors" /id="U2070" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.736263736263736" /psig="0.984015984015984" /xcortree=3092 /SigmaFactorBS="atccctgcaagaatagcaaaaaaccactctacaaaggttcgg ctagctcattctTCTGGTATTATTGAAACAATggtggagcccactggtataaagatcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2398722 /Source="Nicolas_upshifts" /id="U2070" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.736263736263736" /psig="0.984015984015984" /xcortree=3092 /SigmaFactorBS="atccctgcaagaatagcaaaaaaccactctacaaaggttcgg ctagctcattctTCTGGTATTATTGAAACAATggtggagcccactggtataaagatcg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(2399073) /Source="Nicolas_upshifts" /id="D1374" /incds=0 /nref=123 /ntot=254 /MaxReadThrough="2.33762" /MaxDrop="7.47213" /score="6.31571576" /energy="-8.7" /TU="U2071" /idTUdmin="U2071" /TUdmin="-33" /isTUend="FALSE" /label="downshifts" CDS complement(2399099..2399932) /gene="csn" /locus_tag="BSU_26890" /old_locus_tag="BSU26890" /EC_number="3.2.1.132" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11065371, 11320136, 1664582, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11065371, 11320136, 1664582, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="chitosanase" /protein_id="NP_390566.1" /db_xref="EnsemblGenomes-Gn:BSU26890" /db_xref="EnsemblGenomes-Tr:CAB14630" /db_xref="GOA:O07921" /db_xref="InterPro:IPR000400" /db_xref="InterPro:IPR023346" /db_xref="SubtiList:BG11923" /db_xref="UniProtKB/Swiss-Prot:O07921" /translation="MKISMQKADFWKKAAISLLVFTMFFTLMMSETVFAAGLNKDQKR RAEQLTSIFENGTTEIQYGYVERLDDGRGYTCGRAGFTTATGDALEVVEVYTKAVPNN KLKKYLPELRRLAKEESDDTSNLKGFASAWKSLANDKEFRAAQDKVNDHLYYQPAMKR SDNAGLKTALARAVMYDTVIQHGDGDDPDSFYALIKRTNKKAGGSPKDGIDEKKWLNK FLDVRYDDLMNPANHDTRDEWRESVARVDVLRSIAKENNYNLNGPIHVRSNEYGNFVI K*" /label="csn CDS" gene complement(2399099..2399932) /gene="csn" /locus_tag="BSU_26890" /old_locus_tag="BSU26890" /label="csn gene" misc_feature complement(2399962..2399981) /Source="Nicolas_upshift_promotors" /id="U2071" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.84015984015984" /psig="0.992007992007992" /xcortree=504 /SigmaFactorBS="agattcaaaatattgacaaattgatgtattttcaacaatagg gcagtttcTTCATGTATACTGAGTCTGTatttacaatatttagaaaggggaagtgaaa t" /listShort="csn" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2399971) /Source="Nicolas_upshifts" /id="U2071" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.84015984015984" /psig="0.992007992007992" /xcortree=504 /SigmaFactorBS="agattcaaaatattgacaaattgatgtattttcaacaatagg gcagtttcTTCATGTATACTGAGTCTGTatttacaatatttagaaaggggaagtgaaa t" /listShort="csn" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2400137..2400141 /Source="Nicolas_upshift_promotors" /id="U2072" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.450549450549451" /psig="0.992007992007992" /xcortree=490 /SigmaFactorBS="gggaaggtcccttgattttcatactgcttcaactttcattaa caaGATGCcataaggctttactCTATTTTATAATGGAAGTGAtcatcgaaaatcgtta g" /listShort="S1013, yraL" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2400152..2400374 /Source="Nicolas_S_feature" /locus_tag="new_2749037_2749259" /HighExp="Lbstat, M9-stat, B60, M0t90, M40t90, T1.30H, T2.0H, T3.0H, T2.30H, T1.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.97565800000000003" /TUshortSig="SigA" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S1013" upshifts 2400152 /Source="Nicolas_upshifts" /id="U2072" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.450549450549451" /psig="0.992007992007992" /xcortree=490 /SigmaFactorBS="gggaaggtcccttgattttcatactgcttcaactttcattaa caaGATGCcataaggctttactCTATTTTATAATGGAAGTGAtcatcgaaaatcgtta g" /listShort="S1013, yraL" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2400156..2400175 /Source="Nicolas_upshift_promotors" /id="U2072" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.450549450549451" /psig="0.992007992007992" /xcortree=490 /SigmaFactorBS="gggaaggtcccttgattttcatactgcttcaactttcattaa caaGATGCcataaggctttactCTATTTTATAATGGAAGTGAtcatcgaaaatcgtta g" /listShort="S1013, yraL" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2400375..2400638 /gene="yraL" /locus_tag="BSU_26900" /old_locus_tag="BSU26900" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390567.1" /db_xref="EnsemblGenomes-Gn:BSU26900" /db_xref="EnsemblGenomes-Tr:CAB14631" /db_xref="GOA:O07917" /db_xref="InterPro:IPR009057" /db_xref="SubtiList:BG12276" /db_xref="UniProtKB/Swiss-Prot:O07917" /translation="MAYVKATAILPEKLISEIQKYVQGKTIYIPKPESSHQKWGACSG TRKLIDDRNASIKKAFKNGKTIHQLSDEYHLSIETIKKIVYSK*" /label="yraL CDS" gene 2400375..2400638 /gene="yraL" /locus_tag="BSU_26900" /old_locus_tag="BSU26900" /label="yraL gene" downshifts 2400626 /Source="Nicolas_upshifts" /id="D1375" /incds=0 /nref=71 /ntot=223 /MaxReadThrough="1.7419" /MaxDrop="4.94534" /score="-1.04752822" /energy="-9.9" /TU="NA" /idTUdmin="U2072" /TUdmin="-10" /isTUend="TRUE" /label="downshifts" CDS 2400775..2401590 /gene="yraK" /locus_tag="BSU_26910" /old_locus_tag="BSU26910" /function="18.1: Enzymes of unknown specificity" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_390568.2" /db_xref="EnsemblGenomes-Gn:BSU26910" /db_xref="EnsemblGenomes-Tr:CAB14632" /db_xref="GOA:O07937" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12275" /db_xref="UniProtKB/Swiss-Prot:O07937" /translation="MTINNGTLQVPGANIHYQVRGSGPIILLVHGGGGDADKFHHVAN HLANWYTVVTYDRRGHSRSNLANQIEGYRVETHSDDAHRLLAKITNKPAYVFGSSSGA VIGLDLCIRHPEQVHVMIPHEPILLQLLHGNELKQAEQFMEDLKKNHRSEVIKLMSRL ETDEQSKAVLTKRLLGNSTYFTEYEIQGILSYTLDFEALKTVFTSSPMKILPAGGSAS RELFPYRCANALAEQLETEWVEFPGNHTGYTMYHKEFSERLHDMLEKEKKHTC*" /label="yraK CDS" gene 2400775..2401590 /gene="yraK" /locus_tag="BSU_26910" /old_locus_tag="BSU26910" /label="yraK gene" S_feature complement(2401925..2401997) /Source="Nicolas_S_feature" /locus_tag="new_2750810_2750882_c" /HighExp="BC, Lbstat, Sw, M40t90, M0t90, S2, BI, BT, S3, S4" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1014" downshifts complement(2401968) /Source="Nicolas_upshifts" /id="D1376" /incds=0 /nref=44 /ntot=205 /MaxReadThrough="1.43644" /MaxDrop="4.78753" /score="-0.984762906" /energy="-12.6" /TU="NA" /idTUdmin="U2073" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2401998..2402354) /gene="yraJ" /locus_tag="BSU_26920" /old_locus_tag="BSU26920" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390569.2" /db_xref="EnsemblGenomes-Gn:BSU26920" /db_xref="EnsemblGenomes-Tr:CAB14633" /db_xref="InterPro:IPR003646" /db_xref="SubtiList:BG12274" /db_xref="UniProtKB/Swiss-Prot:O07934" /translation="MTKLKMLSMLTVMIASLFIFSSQALAVQYFTVSTSSGAPVNMRS GPGTNYPIMLSIPSGSRVPYYCYAYGTTVTGKYGTSNIWDQIQWKDSRGVVNIGYVSD TYVYTGSDGPVGYKCN*" /label="yraJ CDS" gene complement(2401998..2402354) /gene="yraJ" /locus_tag="BSU_26920" /old_locus_tag="BSU26920" /label="yraJ gene" CDS complement(2402407..2402766) /gene="yraI" /locus_tag="BSU_26930" /old_locus_tag="BSU26930" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390570.2" /db_xref="EnsemblGenomes-Gn:BSU26930" /db_xref="EnsemblGenomes-Tr:CAB14634" /db_xref="InterPro:IPR003646" /db_xref="SubtiList:BG12273" /db_xref="UniProtKB/Swiss-Prot:O07909" /translation="MNKLKRLSMLTVMIASVFIFSSHALAAQYYTVSTSSGAPVNMRS GPGTSWGIVTTIPSGTRIPIYCYKTGTTVTGKYGTSNIWNYTERTLASGEIVPGFVSD TYMYTGSDGPVVPKCSW*" /label="yraI CDS" gene complement(2402407..2402766) /gene="yraI" /locus_tag="BSU_26930" /old_locus_tag="BSU26930" /label="yraI gene" misc_feature complement(2402859..2402878) /Source="Nicolas_upshift_promotors" /id="U2073" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.487512487512487" /psig="0.99100899100899" /xcortree=492 /SigmaFactorBS="tccttaattgtcgaaaacataggaataattccacttttgaaa gatctagttTATGGTACATTGATAAATATatgggaggggagggggcatggtatctgaa a" /listShort="yraI, yraJ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2402869) /Source="Nicolas_upshifts" /id="U2073" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.487512487512487" /psig="0.99100899100899" /xcortree=492 /SigmaFactorBS="tccttaattgtcgaaaacataggaataattccacttttgaaa gatctagttTATGGTACATTGATAAATATatgggaggggagggggcatggtatctgaa a" /listShort="yraI, yraJ" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2403038..2403139) /locus_tag="BSU_26935" /old_locus_tag="BSU26935" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513987.1" /translation="MIGEKGGVSMNREEAWIQGSSTLIELIGGNEAA*" /label="hypothetical protein CDS" gene complement(2403038..2403139) /locus_tag="BSU_26935" /old_locus_tag="BSU26935" /label="gene" S_feature complement(2403179..2403281) /Source="Nicolas_S_feature" /locus_tag="new_2752064_2752166_c" /HighExp="M40t90, LBGstat, M40t45, M0t90, Lbstat, Lbtran, LBGtran, LPhT, ferm, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.575" /TUlongSig="NA" /TUlongPSig="NA" /label="S1015" downshifts complement(2403221) /Source="Nicolas_upshifts" /id="D1377" /incds=0 /nref=19 /ntot=188 /MaxReadThrough="2.12056" /MaxDrop="4.09264" /score="-0.984762906" /energy="-12.6" /TU="NA" /idTUdmin="U2074" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2403282..2403668) /gene="yraH" /locus_tag="BSU_26940" /old_locus_tag="BSU26940" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative lyase" /protein_id="NP_390571.1" /db_xref="EnsemblGenomes-Gn:BSU26940" /db_xref="EnsemblGenomes-Tr:CAB14635" /db_xref="GOA:O07918" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR018146" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG12272" /db_xref="UniProtKB/Swiss-Prot:O07918" /translation="MKLLQIRLLVNDFKKSVEFYKDSLGLPISWLENEMEYALFDNGE TKIELLSRETMAEIVGEEKKSLEGEAQSKFLLQFKVEDVDKTYDDLHEKGVKCENKPH DRKEWSARVAHFRDPDHNLIEIYKML*" /label="yraH CDS" gene complement(2403282..2403668) /gene="yraH" /locus_tag="BSU_26940" /old_locus_tag="BSU26940" /label="yraH gene" misc_feature complement(2403710..2403726) /Source="Nicolas_upshift_promotors" /id="U2074" /multdbtbs="-" /comp="M18" /sig="SigA" /pcomp="0.245754245754246" /psig="0.575424575424575" /xcortree=1510 /SigmaFactorBS="tgcacttaaatctgaaataagggtgaagtatggaaacttgac atagtgctgtcaggtttcTTTGGTATCATTAAATTggatgaccagtaaaagtatggtt t" /listShort="yraH, S1015" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2403726) /Source="Nicolas_upshifts" /id="U2074" /multdbtbs="-" /comp="M18" /sig="SigA" /pcomp="0.245754245754246" /psig="0.575424575424575" /xcortree=1510 /SigmaFactorBS="tgcacttaaatctgaaataagggtgaagtatggaaacttgac atagtgctgtcaggtttcTTTGGTATCATTAAATTggatgaccagtaaaagtatggtt t" /listShort="yraH, S1015" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2403859..2403865 /Source="Nicolas_upshift_promotors" /id="U2075" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=887 /SigmaFactorBS="gcgattcttaaaacaaaaaatgataccgagtgtattttcTGT ATGCttcaacttcatttcGGGAAATGTAACgttgataaaaggaggttacatcaatatg g" /listShort="yraG, yraF, adhB, yraE, yraD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2403880..2403891 /Source="Nicolas_upshift_promotors" /id="U2075" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=887 /SigmaFactorBS="gcgattcttaaaacaaaaaatgataccgagtgtattttcTGT ATGCttcaacttcatttcGGGAAATGTAACgttgataaaaggaggttacatcaatatg g" /listShort="yraG, yraF, adhB, yraE, yraD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2403880 /Source="Nicolas_upshifts" /id="U2075" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=887 /SigmaFactorBS="gcgattcttaaaacaaaaaatgataccgagtgtattttcTGT ATGCttcaacttcatttcGGGAAATGTAACgttgataaaaggaggttacatcaatatg g" /listShort="yraG, yraF, adhB, yraE, yraD" /GFF_Attribute="listLong" /label="upshifts" CDS 2403917..2404162 /gene="yraG" /locus_tag="BSU_26950" /old_locus_tag="BSU26950" /function="16.5: Explore" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10066829, 22882546; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="NP_390572.1" /db_xref="EnsemblGenomes-Gn:BSU26950" /db_xref="EnsemblGenomes-Tr:CAB14636" /db_xref="GOA:O07919" /db_xref="InterPro:IPR012347" /db_xref="SubtiList:BG12271" /db_xref="UniProtKB/Swiss-Prot:O07919" /translation="MDHQTLAAHEAVDLHEIVNFKTLCIAKSKLMQGLVFDQELKDLM EKDVQQSIQDLTELQAVYERASFQAPVPQSRPTPIIN*" /label="yraG CDS" gene 2403917..2404162 /gene="yraG" /locus_tag="BSU_26950" /old_locus_tag="BSU26950" /label="yraG gene" CDS 2404180..2404548 /gene="yraF" /locus_tag="BSU_26960" /old_locus_tag="BSU26960" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10066829, 22882546; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="NP_390573.1" /db_xref="EnsemblGenomes-Gn:BSU26960" /db_xref="EnsemblGenomes-Tr:CAB14637" /db_xref="GOA:O07949" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR012851" /db_xref="SubtiList:BG12270" /db_xref="UniProtKB/Swiss-Prot:O07949" /translation="MNNDHLDPINSLNVPELADTTFAMDFLIRAKEGVRNTAVALTET ASPDVRALLRKQLMQGIAMHQEITELMISKKWFHPYELSEQYKLDQLSAKNTIMVGNM NLFPDETNRKGMFDRTPDEH*" /label="yraF CDS" gene 2404180..2404548 /gene="yraF" /locus_tag="BSU_26960" /old_locus_tag="BSU26960" /label="yraF gene" CDS 2404567..2405703 /gene="adhB" /locus_tag="BSU_26970" /old_locus_tag="BSU26970" /EC_number="1.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7926692, 17586670; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase (involving bacillithiol)" /protein_id="NP_390574.2" /db_xref="EnsemblGenomes-Gn:BSU26970" /db_xref="EnsemblGenomes-Tr:CAB14638" /db_xref="GOA:O06012" /db_xref="InterPro:IPR002328" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR027399" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11902" /db_xref="UniProtKB/Swiss-Prot:O06012" /translation="MKAVTYQGIKNVVVKDVPDPKIEKSDDMIIKVTSTAICGSDLHL IHGFIPNMQEDYVIGHEPMGIVEEVGSGVTKLKKGDRVIIPFNIACGECFFCKNQLES QCDQSNDNGEMGAYFGYSGQTGGYPGGQAEYLRVPFANFTHFKIPESCEEPDEKLSVI ADAMTTGFWSVDNAGVKKGDTVIVLGCGPVGLFAQKFCWLKGAKRVIAVDYVNYRLQH AKRTNKVEIVNFEDHENTGNYLKEITKGGADVVIDAVGMDGKMSDLEFLASGLKLHGG TMSALVIASQAVRKGGTIQITGVYGGRYNGFPLGDIMQRNVNIRSGQAPVIHYMPYMF ELVSTGKIDPGDVVSHVLPLSEAKHGYDIFDSKMDDCIKVVLKP*" /label="adhB CDS" gene 2404567..2405703 /gene="adhB" /locus_tag="BSU_26970" /old_locus_tag="BSU26970" /label="adhB gene" CDS 2405722..2405919 /gene="yraE" /locus_tag="BSU_26980" /old_locus_tag="BSU26980" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10066829, 22882546; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="NP_390575.1" /db_xref="EnsemblGenomes-Gn:BSU26980" /db_xref="EnsemblGenomes-Tr:CAB14639" /db_xref="InterPro:IPR012347" /db_xref="SubtiList:BG13780" /db_xref="UniProtKB/Swiss-Prot:O06011" /translation="MEYALHEVLEVQEMTAFKTLCLTKSKTMKALVSDPKLKEIMQQD VDITTRQLQEFASILSNAKQE*" /label="yraE CDS" gene 2405722..2405919 /gene="yraE" /locus_tag="BSU_26980" /old_locus_tag="BSU26980" /label="yraE gene" CDS 2405935..2406234 /gene="yraD" /locus_tag="BSU_26990" /old_locus_tag="BSU26990" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10066829, 22882546; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative spore coat protein" /protein_id="NP_390576.1" /db_xref="EnsemblGenomes-Gn:BSU26990" /db_xref="EnsemblGenomes-Tr:CAB14640" /db_xref="GOA:O06010" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR012851" /db_xref="SubtiList:BG13779" /db_xref="UniProtKB/Swiss-Prot:O06010" /translation="MNPIIEYLTGMNVLTDQIIAMDLLISAKNGVRNYAMAATEAGTP EVKEVLIRHLEEALDMHEQLSSYMMEKGWYHPWNPDEQVKLNLKNIDTAIQLPTL*" /label="yraD CDS" gene 2405935..2406234 /gene="yraD" /locus_tag="BSU_26990" /old_locus_tag="BSU26990" /label="yraD gene" downshifts 2406225 /Source="Nicolas_upshifts" /id="D1378" /incds=0 /nref=11 /ntot=39 /MaxReadThrough="1.62449" /MaxDrop="3.8153" /score="-8.57687054" /energy="-10.7" /TU="NA" /idTUdmin="U2075" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2406497..2406919) /gene="adhR" /locus_tag="BSU_27000" /old_locus_tag="BSU27000" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14663075, 17962296, 19170879" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14663075, 17962296, 19170879; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator regulated by thiol-alkylation" /protein_id="NP_390578.2" /db_xref="EnsemblGenomes-Gn:BSU27000" /db_xref="EnsemblGenomes-Tr:CAB14642" /db_xref="GOA:O06008" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="SubtiList:BG13777" /db_xref="UniProtKB/Swiss-Prot:O06008" /translation="MNIAQVAKQFGLTAATLRYYERVGLIPPVKRKDSGIRDYDEEDI KWIEFIKCMRNAGLSIEALIEYTTLFTEGDRTVEARKNILADERQRLIEKRKEIDETI KRLDTKIKDYDGKLRENEAKLKSRPKTESLHGSVEQRR*" /label="adhR CDS" gene complement(2406497..2406919) /gene="adhR" /locus_tag="BSU_27000" /old_locus_tag="BSU27000" /label="adhR gene" promotor_-35 2406917..2406920 /Source="Nicolas_upshift_promotors" /id="U2076" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.547452547452547" /psig="0.926073926073926" /xcortree=2007 /SigmaFactorBS="aactgctttgccacctgagcaatattCATGatcttcacctct ctaTCCTGTATGTTGTGAAGGTAacacttaaagttaactttaagtcaagctcaaaaca a" /listShort="S1016, yrzP, S1017, adhA" /listLong="yraA, S1018" /label="promotor_-35" promotor_-10 2406936..2406955 /Source="Nicolas_upshift_promotors" /id="U2076" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.547452547452547" /psig="0.926073926073926" /xcortree=2007 /SigmaFactorBS="aactgctttgccacctgagcaatattCATGatcttcacctct ctaTCCTGTATGTTGTGAAGGTAacacttaaagttaactttaagtcaagctcaaaaca a" /listShort="S1016, yrzP, S1017, adhA" /listLong="yraA, S1018" /label="promotor_-10" S_feature 2406951..2407101 /Source="Nicolas_S_feature" /locus_tag="new_2755836_2755986" /HighExp="Diami, dia15, dia5, H2O2, S8, Paraq, S5, G180, S6, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.926" /TUlongSig="NA" /TUlongPSig="NA" /label="S1016" upshifts 2406951 /Source="Nicolas_upshifts" /id="U2076" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.547452547452547" /psig="0.926073926073926" /xcortree=2007 /SigmaFactorBS="aactgctttgccacctgagcaatattCATGatcttcacctct ctaTCCTGTATGTTGTGAAGGTAacacttaaagttaactttaagtcaagctcaaaaca a" /listShort="S1016, yrzP, S1017, adhA" /listLong="yraA, S1018" /label="upshifts" promotor_-10 complement(2406954..2406973) /Source="Nicolas_upshift_promotors" /id="U2077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.947052947052947" /psig="0.984015984015984" /xcortree=2044 /SigmaFactorBS="tatataaacccagattcagcagctaacCACTTGTTttgagct tgacttAAAGTTAACTTTAAGTGTTAccttcacaacatacaggatagagaggtgaaga t" /listShort="yraB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2406961) /Source="Nicolas_upshifts" /id="U2077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.947052947052947" /psig="0.984015984015984" /xcortree=2044 /SigmaFactorBS="tatataaacccagattcagcagctaacCACTTGTTttgagct tgacttAAAGTTAACTTTAAGTGTTAccttcacaacatacaggatagagaggtgaaga t" /listShort="yraB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2406987..2406994) /Source="Nicolas_upshift_promotors" /id="U2077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.947052947052947" /psig="0.984015984015984" /xcortree=2044 /SigmaFactorBS="tatataaacccagattcagcagctaacCACTTGTTttgagct tgacttAAAGTTAACTTTAAGTGTTAccttcacaacatacaggatagagaggtgaaga t" /listShort="yraB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2407070..2407089) /Source="Nicolas_upshift_promotors" /id="U2078" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.975024975024975" /psig="0.99000999000999" /xcortree=630 /SigmaFactorBS="ctaattgttctcttccggcagtgtgttTATTTGCCattcagc aatccctCCAACTACACTGTTTTTAGTgcatggagaagtatagagtttaaagtgtgct t" /GFF_Attribute="listShort" /listLong="yraB" /label="promotor_-10" upshifts complement(2407078) /Source="Nicolas_upshifts" /id="U2078" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.975024975024975" /psig="0.99000999000999" /xcortree=630 /SigmaFactorBS="ctaattgttctcttccggcagtgtgttTATTTGCCattcagc aatccctCCAACTACACTGTTTTTAGTgcatggagaagtatagagtttaaagtgtgct t" /GFF_Attribute="listShort" /listLong="yraB" /label="upshifts" CDS 2407102..2407296 /gene="yrzP" /locus_tag="BSU_27009" /old_locus_tag="BSU27009" /EC_number="4.1.1.44" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17962296, 19170879; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative carboxymuconolactone decarboxylase" /protein_id="YP_009513988.1" /db_xref="EnsemblGenomes-Gn:BSU27009" /db_xref="EnsemblGenomes-Tr:CAX52671" /db_xref="InterPro:IPR029032" /db_xref="UniProtKB/TrEMBL:C0H460" /translation="MANKHTAGREQLGEFAPKFAELHDDVLFGDIWAREEELSSRDRS MITVSALITDCFSAYKSGSF*" /label="yrzP CDS" gene 2407102..2407296 /gene="yrzP" /locus_tag="BSU_27009" /old_locus_tag="BSU27009" /label="yrzP gene" promotor_-35 complement(2407104..2407111) /Source="Nicolas_upshift_promotors" /id="U2078" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.975024975024975" /psig="0.99000999000999" /xcortree=630 /SigmaFactorBS="ctaattgttctcttccggcagtgtgttTATTTGCCattcagc aatccctCCAACTACACTGTTTTTAGTgcatggagaagtatagagtttaaagtgtgct t" /GFF_Attribute="listShort" /listLong="yraB" /label="promotor_-35" promotor_-35 2407314..2407321 /Source="Nicolas_upshift_promotors" /id="U2079" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.952047952047952" /psig="0.987012987012987" /xcortree=2722 /SigmaFactorBS="atcaggttcattttaaatggtttttttaaaaaaCCCTTGCCt taaagcagactttaAGGTTTATCGTTATGTTGAAgacaccataaaacataaataagtg c" /listShort="S1017, adhA" /listLong="yraA" /label="promotor_-35" promotor_-10 2407337..2407356 /Source="Nicolas_upshift_promotors" /id="U2079" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.952047952047952" /psig="0.987012987012987" /xcortree=2722 /SigmaFactorBS="atcaggttcattttaaatggtttttttaaaaaaCCCTTGCCt taaagcagactttaAGGTTTATCGTTATGTTGAAgacaccataaaacataaataagtg c" /listShort="S1017, adhA" /listLong="yraA" /label="promotor_-10" upshifts 2407341 /Source="Nicolas_upshifts" /id="U2079" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.952047952047952" /psig="0.987012987012987" /xcortree=2722 /SigmaFactorBS="atcaggttcattttaaatggtttttttaaaaaaCCCTTGCCt taaagcagactttaAGGTTTATCGTTATGTTGAAgacaccataaaacataaataagtg c" /listShort="S1017, adhA" /listLong="yraA" /label="upshifts" S_feature 2407342..2407426 /Source="Nicolas_S_feature" /locus_tag="new_2756227_2756311" /HighExp="LBGstat, dia15, Diami, LPhT, LBGtran, dia5, M40t90, Lbtran, H2O2, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.987, 0.926" /TUlongSig="NA" /TUlongPSig="NA" /label="S1017" CDS 2407427..2408476 /gene="adhA" /locus_tag="BSU_27010" /old_locus_tag="BSU27010" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 19170879; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aldehyde dehydrogenase; carbonyl stressresponse" /protein_id="NP_390579.2" /db_xref="EnsemblGenomes-Gn:BSU27010" /db_xref="EnsemblGenomes-Tr:CAB14643" /db_xref="GOA:C0SPA5" /db_xref="InterPro:IPR002328" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR020843" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12562" /db_xref="UniProtKB/Swiss-Prot:C0SPA5" /translation="MCNQHQTRVLSVSHAKAKFEQTTIERRGLRPHDVLIDIKFSGIC HSDIHSAFDEWGGGIFPMVPGHEIAGVVTAVGTKVTKLAVGDRVGVGCFVDSCGECEY CLNAEEQFCTKGVVQTYNSVDYDGNPTYGGYSQKIVVTDRFVVRIPDRLEMDVASPLL CAGITTYSPLKHWNVGPGKKVAIVGVGGLGHLAIQFAHAMGAEVTVLSRSMNKKEEAL ELGANHYFATSDPATFTALAGRFDVILNTVSANLDVDAYLSMLRIDGTLVSVGAPAKP DTYSVFSLIMGRRSIAGSLVGGIQETQEMLDFAAEHGIEPKIEVIGADQVDEAYERIL RSDVRYRFVIDISTL*" /label="adhA CDS" gene 2407427..2408476 /gene="adhA" /locus_tag="BSU_27010" /old_locus_tag="BSU27010" /label="adhA gene" promotor_-35 2408544..2408551 /Source="Nicolas_upshift_promotors" /id="U2080" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2035 /SigmaFactorBS="cgaaaaatgatctctttaagcaaatATTTTGAAggccggtca atcttCCTGTTATTCTATGAATAGAgagttattaggagggttttttatgagcaaaaaa a" /listShort="yraA, S1018" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2408566..2408585 /Source="Nicolas_upshift_promotors" /id="U2080" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2035 /SigmaFactorBS="cgaaaaatgatctctttaagcaaatATTTTGAAggccggtca atcttCCTGTTATTCTATGAATAGAgagttattaggagggttttttatgagcaaaaaa a" /listShort="yraA, S1018" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2408579 /Source="Nicolas_upshifts" /id="U2080" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2035 /SigmaFactorBS="cgaaaaatgatctctttaagcaaatATTTTGAAggccggtca atcttCCTGTTATTCTATGAATAGAgagttattaggagggttttttatgagcaaaaaa a" /listShort="yraA, S1018" /GFF_Attribute="listLong" /label="upshifts" CDS 2408607..2409116 /gene="sufL" /locus_tag="BSU_27020" /old_locus_tag="BSU27020" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12775685, 17257049, 17933887, 24330391, 26774339; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="deglycase; general stress protecting enzyme; protects against methylglyoxal toxicity" /protein_id="NP_390580.2" /db_xref="EnsemblGenomes-Gn:BSU27020" /db_xref="EnsemblGenomes-Tr:CAB14644" /db_xref="GOA:O06006" /db_xref="InterPro:IPR002818" /db_xref="InterPro:IPR006286" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG13776" /db_xref="UniProtKB/Swiss-Prot:O06006" /translation="MSKKIAVLVTDQFEDIEYTSPVKAYEEAGYSVVAIDLEAGKEVT GKHGEKVKIDKAISDVDASDFDALLIPGGFSPDLLRADDRPGEFAKAFVENKKPVFAI CHGPQVLIDTDLLKGKDITGYRSIRKDLINAGANYKDAEVVVSHNIVTSRTPDDLEAF NRESLNLLK*" /label="sufL CDS" gene 2408607..2409116 /gene="sufL" /locus_tag="BSU_27020" /old_locus_tag="BSU27020" /label="sufL gene" downshifts 2409085 /Source="Nicolas_upshifts" /id="D1379" /incds=0 /nref=178 /ntot=254 /MaxReadThrough="4.08169" /MaxDrop="5.1444" /score="24.8267602" /energy="-16.3" /TU="U2080" /idTUdmin="U2076" /TUdmin=528 /isTUend="FALSE" /label="downshifts" S_feature 2409130..2410235 /Source="Nicolas_S_feature" /locus_tag="new_2758015_2759120" /HighExp="Diami, dia5, Etha, dia15, LPhT, H2O2, Lbstat, Salt, Fru, Paraq" /AntisenseName="sacC" /AntisenseCor="0.18236909579254801" /AntisenseRegPval="-2.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.926" /label="S1018" CDS complement(2409158..2411191) /gene="sacC" /locus_tag="BSU_27030" /old_locus_tag="BSU27030" /EC_number="3.2.1.7" /EC_number="3.2.1.65" /EC_number="3.2.1.80" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7646030, 8057358, 10217495, 12224641" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7646030, 8057358, 10217495, 12224641; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="levanase" /protein_id="NP_390581.1" /db_xref="EnsemblGenomes-Gn:BSU27030" /db_xref="EnsemblGenomes-Tr:CAB14645" /db_xref="GOA:P05656" /db_xref="InterPro:IPR001362" /db_xref="InterPro:IPR013148" /db_xref="InterPro:IPR013189" /db_xref="InterPro:IPR013320" /db_xref="InterPro:IPR018053" /db_xref="InterPro:IPR023296" /db_xref="PDB:4AZZ" /db_xref="PDB:4B1L" /db_xref="PDB:4B1M" /db_xref="SubtiList:BG10320" /db_xref="UniProtKB/Swiss-Prot:P05656" /translation="MKKRLIQVMIMFTLLLTMAFSADAADSSYYDEDYRPQYHFTPEA NWMNDPNGMVYYAGEYHLFYQYHPYGLQWGPMHWGHAVSKDLVTWEHLPVALYPDEKG TIFSGSAVVDKNNTSGFQTGKEKPLVAIYTQDREGHQVQSIAYSNDKGRTWTKYAGNP VIPNPGKKDFRDPKVFWYEKEKKWVMVLAAGDRILIYTSKNLKQWTYASEFGQDQGSH GGVWECPDLFELPVDGNPNQKKWVMQVSVGNGAVSGGSGMQYFVGDFDGTHFKNENPP NKVLWTDYGRDFYAAVSWSDIPSTDSRRLWLGWMSNWQYANDVPTSPWRSATSIPREL KLKAFTEGVRVVQTPVKELETIRGTSKKWKNLTISPASHNVLAGQSGDAYEINAEFKV SPGSAAEFGFKVRTGENQFTKVGYDRRNAKLFVDRSESGNDTFNPAFNTGKETAPLKP VNGKVKLRIFVDRSSVEVFGNDGKQVITDIILPDRSSKGLELYAANGGVKVKSLTIHP LKKVWGTTPFMSNMTGWTTVNGTWADTIEGKQGRSDGDSFILSSASGSDFTYESDITI KDGNGRGAGALMFRSDKDAKNGYLANVDAKHDLVKFFKFENGAASVIAEYKTPIDVNK KYHLKTEAEGDRFKIYLDDRLVIDAHDSVFSEGQFGLNVWDATAVFQNVTKES*" /label="sacC CDS" gene complement(2409158..2411191) /gene="sacC" /locus_tag="BSU_27030" /old_locus_tag="BSU27030" /label="sacC gene" downshifts complement(2409183) /Source="Nicolas_upshifts" /id="D1380" /incds=0 /nref=14 /ntot=60 /MaxReadThrough="0.56875" /MaxDrop="5.09923" /score="-2.07442916" /energy="-14.2" /TU="NA" /idTUdmin="U2081" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2411100..2411267) /locus_tag="BSU_27035" /old_locus_tag="BSU27035" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513989.1" /translation="MPETDQLAQQSLLKVFKHEERSEGTNEKETDSSHDHVHPAVDYG IFGRCSRFKLL*" /label="hypothetical protein CDS" gene complement(2411100..2411267) /locus_tag="BSU_27035" /old_locus_tag="BSU27035" /label="gene" S_feature complement(2411192..2411347) /Source="Nicolas_S_feature" /locus_tag="new_2760077_2760232_c" /HighExp="UNK1, Fru, B60, T0.30H, M40t90, M0t90, ferm, LPh, GM-0.2, GM-0.1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigL" /TUshortPSig="0.886" /TUlongSig="NA" /TUlongPSig="NA" /label="S1019" CDS complement(2411348..2412175) /gene="levG" /locus_tag="BSU_27040" /old_locus_tag="BSU27040" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:2117666, 9033408, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2117666, 9033408, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) fructose-specific enzyme IID component" /protein_id="NP_390582.1" /db_xref="EnsemblGenomes-Gn:BSU27040" /db_xref="EnsemblGenomes-Tr:CAB14646" /db_xref="GOA:P26382" /db_xref="InterPro:IPR004704" /db_xref="SubtiList:BG10319" /db_xref="UniProtKB/Swiss-Prot:P26382" /translation="MEKEKRLTKKEIFSMFIRSNFLLGSFNFERVQAMGYCYVMIPAI KKLYGPGAKRNEALQRHLEWFNTHPWLTAPIFGVTAAMEEEMANNKGIDGKAISGMKI GLMGPIAGVGDPIFWGTIRPVLAALGASLALGGNIAGPLLFFFLLNAIRLSTKYYGLK YGYVKGMEILQDLAGNRIQKLTEGASILGLFVMGALVSKWTTINIPIVVSRIKDESGK VDVQTVQNVLDSIMPGALPLGLTLLVAWMLRKGVNPLLIICGIFVIGILGYWAGFLA* " /label="levG CDS" gene complement(2411348..2412175) /gene="levG" /locus_tag="BSU_27040" /old_locus_tag="BSU27040" /label="levG gene" CDS complement(2412196..2413005) /gene="levF" /locus_tag="BSU_27050" /old_locus_tag="BSU27050" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:2117666, 9033408, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2117666, 9033408, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) fructose-specific enzyme IIC component" /protein_id="NP_390583.1" /db_xref="EnsemblGenomes-Gn:BSU27050" /db_xref="EnsemblGenomes-Tr:CAB14647" /db_xref="GOA:P26381" /db_xref="InterPro:IPR004700" /db_xref="SubtiList:BG10318" /db_xref="UniProtKB/Swiss-Prot:P26381" /translation="MSSLQIILLLIIAAITGIASVLDEGQTHRPLVACTLVGLVLGDL KTGIILGGTLELMALGWMNVGLAMAPDTAIASVISTILVITADQGIGEGIAVAVALAA AGQALTIFVRTITVFFIHRADQYAKAGNIKGIEIMHITAMVFQALRVMIPTLIVALIS VSAVQAFLGNIPDVITKGLQIGGGIIVVVGYAMVINMMNIPYLKPFFYIGFLLAAFTD FNLVGFGALGLCLALLYQQVMQKQSAHGAVAAASDSGSVAVYDDDDDDLDA*" /label="levF CDS" gene complement(2412196..2413005) /gene="levF" /locus_tag="BSU_27050" /old_locus_tag="BSU27050" /label="levF gene" CDS complement(2413022..2413510) /gene="levE" /locus_tag="BSU_27060" /old_locus_tag="BSU27060" /EC_number="2.7.1.202" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:2117666, 9033408, 9622354, 10589728" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2117666, 9033408, 9622354, 10589728; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) fructose-specific enzyme IIB component" /protein_id="NP_390584.1" /db_xref="EnsemblGenomes-Gn:BSU27060" /db_xref="EnsemblGenomes-Tr:CAB14648" /db_xref="GOA:P26380" /db_xref="InterPro:IPR004720" /db_xref="InterPro:IPR018455" /db_xref="InterPro:IPR036667" /db_xref="PDB:1BLE" /db_xref="SubtiList:BG10317" /db_xref="UniProtKB/Swiss-Prot:P26380" /translation="MNIVLARIDDRFIHGQILTRWIKVHAADRIIVVSDDIAQDEMRK TLILSVAPSNVKASAVSVSKMAKAFHSPRYEGVTAMLLFENPSDIVSLIEAGVPIKTV NVGGMRFENHRRQITKSVSVTEQDIKAFETLSDKGVKLELRQLPSDASEDFVQILRNV TK*" /label="levE CDS" gene complement(2413022..2413510) /gene="levE" /locus_tag="BSU_27060" /old_locus_tag="BSU27060" /label="levE gene" CDS complement(2413510..2413950) /gene="levD" /locus_tag="BSU_27070" /old_locus_tag="BSU27070" /EC_number="2.7.1.202" /function="16.3: Control" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:2117666, 9033408" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2117666, 9033408; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) fructose-specific enzyme IIA component" /protein_id="NP_390585.1" /db_xref="EnsemblGenomes-Gn:BSU27070" /db_xref="EnsemblGenomes-Tr:CAB14649" /db_xref="GOA:P26379" /db_xref="InterPro:IPR004701" /db_xref="InterPro:IPR013789" /db_xref="InterPro:IPR033887" /db_xref="InterPro:IPR036662" /db_xref="SubtiList:BG10316" /db_xref="UniProtKB/Swiss-Prot:P26379" /translation="MISVIISGHGDFPIALKESSGMIFGEENNLIAVPFFKGEGIQTL QEKYHQALKDIPEEHEVLFLVDIFGGTPYNAAASFIAEDQRMDMAAGVNLPILLEVLS LREHLALKDLLNNLKAMSQQSFQVCSEHLEKVKTANQDTREDEL*" /label="levD CDS" gene complement(2413510..2413950) /gene="levD" /locus_tag="BSU_27070" /old_locus_tag="BSU27070" /label="levD gene" downshifts 2413947 /Source="Nicolas_upshifts" /id="D1381" /incds=0 /nref=2 /ntot=5 /MaxReadThrough="0.496260000000001" /MaxDrop="4.58461" /score="24.8267602" /energy="-16.3" /TU="NA" /idTUdmin="U2080" /TUdmin=3740 /isTUend="FALSE" /label="downshifts" misc_feature complement(2413987..2414005) /Source="Nicolas_upshift_promotors" /id="U2081" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.886113886113886" /psig="0.886113886113886" /xcortree=1498 /SigmaFactorBS="ttgctattggctgaaataacaatgaaaacgcttaacacaact gtgtTGGCACGATCCTTGCATTAtatatggatgtacaaaacaggaaaggagcaataga t" /listShort="levD, levE, levF, levG, S1019, sacC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2413991) /Source="Nicolas_upshifts" /id="U2081" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.886113886113886" /psig="0.886113886113886" /xcortree=1498 /SigmaFactorBS="ttgctattggctgaaataacaatgaaaacgcttaacacaact gtgtTGGCACGATCCTTGCATTAtatatggatgtacaaaacaggaaaggagcaataga t" /listShort="levD, levE, levF, levG, S1019, sacC" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2414140..2416947) /gene="levR" /locus_tag="BSU_27080" /old_locus_tag="BSU27080" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1619665, 1900939, 7592487, 8057358, 9622354, 10589728, 19202299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1619665, 1900939, 7592487, 8057358, 9622354, 10589728, 19202299; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (NifA/NtrC family)" /protein_id="NP_390586.2" /db_xref="EnsemblGenomes-Gn:BSU27080" /db_xref="EnsemblGenomes-Tr:CAB14650" /db_xref="GOA:P23914" /db_xref="InterPro:IPR001550" /db_xref="InterPro:IPR002078" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004701" /db_xref="InterPro:IPR011608" /db_xref="InterPro:IPR025943" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR033887" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="InterPro:IPR036634" /db_xref="InterPro:IPR036662" /db_xref="SubtiList:BG10677" /db_xref="UniProtKB/Swiss-Prot:P23914" /translation="MRRIDKIYHQLKHNFHDSTLDHLLKIQGNSAKEIAEQLKMERSN VSFELNNLVRSKKVIKIKTFPVRYIPVEIAEKLFNKKWDTEMMEVKDLQAFSGNSKQN HQHISTNPLELMIGAKGSLKKAISQAKAAVFYPPNGLHMLLLGPTGSGKSLFANRIYQ FAIYSDILKAGAPFITFNCADYYNNPQLLLSQLFGHKKGSFTGAAEDKAGLVEQANGG ILFMDEIHRLPPEGQEMLFYFIDSGSYNRLGESEHKRTSNVLFICATTENPSSALLKT FLRRIPMTIHIPSLEERSLNERVDLTTFLLGKEAERIKKNLSVHIDVYNALIHSAKFG NVGQLKSNVQLVCAHGFLHNLDRNEVIELTVRDLPDEIKQEWMSSSKNMQRSKAISEY VNITTIISPIVEDETTKIDEDLSFNLYHLIEEKVKTLMKEGLSKKDINQYILTDVHLH VRSFFHHQAFQKDNLLTFVEDDVIQMTKQLKEIAEHELDCTFDRKFIYFLSMHIDAFL KRGKQIDVLNTQETDEIRDTHVKEYRVAMIFKDKIQEYFKVAIPEIEVIYLTMLIHSI KSLKENKRVGIIVAAHGNSTASSMVEVATELLGSTPIAAVDMPLTVSPSDILECVAEK MKQVDEGEGVLMLVDMGSLAMLESRLEEKTGISIKTISNVTTSMVLDAVRKVNYLNLN LHAIYQSVTKDFIELWERQPAASGKKKALVSICTTGSGTAKKLEDILTTIVNKASDTP IHILTVSSIKLANSIKEIEKEYEILATVGTKDPKINAPHVSLEVLIEGEGEKLIQQAI TKGSISLSNGLNEANIIVRELCEDSLKKYLVFLNPHHVIDMLLEWLQTVQDELGVIFN NAVLIKVIMHTAFAFERVIKQNPIAFSEEEEINDQLKEMVYVTERTLAPYEEKLGLRI SDDEKLFIAAIFAEEVHGQLF*" /label="levR CDS" gene complement(2414140..2416947) /gene="levR" /locus_tag="BSU_27080" /old_locus_tag="BSU27080" /label="levR gene" misc_feature complement(2417163..2417182) /Source="Nicolas_upshift_promotors" /id="U2082" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.743256743256743" /psig="0.957042957042957" /xcortree=2981 /SigmaFactorBS="attcattttttgtcattgattattttgacatcattacattcc ccgagAATGATAAACTGTTTACTGAttattacttttgaaggggactggccctccagaa c" /listShort="levR" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2417169) /Source="Nicolas_upshifts" /id="U2082" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.743256743256743" /psig="0.957042957042957" /xcortree=2981 /SigmaFactorBS="attcattttttgtcattgattattttgacatcattacattcc ccgagAATGATAAACTGTTTACTGAttattacttttgaaggggactggccctccagaa c" /listShort="levR" /GFF_Attribute="listLong" /label="upshifts" CDS 2417494..2417634 /locus_tag="BSU_27085" /old_locus_tag="BSU27085" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513990.1" /translation="MTFLFYSAIQVESRVKNRATRHVTALKIVLKFKNKSIYSFKCYN IR*" /label="hypothetical protein CDS" gene 2417494..2417634 /locus_tag="BSU_27085" /old_locus_tag="BSU27085" /label="gene" misc_feature 2417615..2417634 /Source="Nicolas_upshift_promotors" /id="U2083" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.929070929070929" /psig="0.997002997002997" /xcortree=1762 /SigmaFactorBS="agcacttaaaatagttttaaaatttaaaaataaaagtatcta ttcttttaAATGTTATAATATCCGATAAaactttactcatctttttattactggagga a" /listShort="aapA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2417625 /Source="Nicolas_upshifts" /id="U2083" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.929070929070929" /psig="0.997002997002997" /xcortree=1762 /SigmaFactorBS="agcacttaaaatagttttaaaatttaaaaataaaagtatcta ttcttttaAATGTTATAATATCCGATAAaactttactcatctttttattactggagga a" /listShort="aapA" /GFF_Attribute="listLong" /label="upshifts" CDS 2417673..2419061 /gene="aapA" /locus_tag="BSU_27090" /old_locus_tag="BSU27090" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16850406, 17608695, 22084243; Product type t: transporter" /codon_start=1 /transl_table=11 /product="small amino acid permease" /protein_id="NP_390587.2" /db_xref="EnsemblGenomes-Gn:BSU27090" /db_xref="EnsemblGenomes-Tr:CAB14651" /db_xref="GOA:O06005" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG12556" /db_xref="UniProtKB/Swiss-Prot:O06005" /translation="MIGNSSKDNFGQQQKLSRGLKNRHIQLMAIGGAIGTGLFLGSGK SIHFAGPSILFAYLITGVFCFFIMRSLGELLLSNAGYHSFVDFVRDYLGNMAAFITGW TYWFCWISLAMADLTAVGIYTQYWLPDVPQWLPGLLALIILLIMNLATVKLFGELEFW FALIKVIAILALIVTGILLIAKGFSAASGPASLNNLWSHGGMFPNGWHGFILSFQMVV FAFVGIELVGLTAGETENPQKVIPKAINQIPVRILLFYVGALFVIMCIYPWNVLNPNE SPFVQVFSAVGIVVAASLINFVVLTSAASAANSALFSTSRMVYSLAKDHHAPGLLKKL TSSNVPSNALFFSSIAILIGVSLNYLMPEQVFTLITSVSTICFIFIWGITVICHLKYR KTRQHEAKANKFKMPFYPLSNYLTLAFLAFILVILALANDTRIALFVTPVWFVLLIIL YKVQTRRGHKVK*" /label="aapA CDS" gene 2417673..2419061 /gene="aapA" /locus_tag="BSU_27090" /old_locus_tag="BSU27090" /label="aapA gene" downshifts 2419050 /Source="Nicolas_upshifts" /id="D1382" /incds=0 /nref=7 /ntot=120 /MaxReadThrough="0.96985" /MaxDrop="3.54068" /score="11.8049306" /energy="-13" /TU="NA" /idTUdmin="U2083" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" S_feature complement(2419083..2419156) /Source="Nicolas_S_feature" /locus_tag="new_2767968_2768041_c" /HighExp="MG 120, LBGstat, MG 150, MG 90, S0, HPh, HiOs, GM-0.1, aero, GM 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1020" downshifts complement(2419125) /Source="Nicolas_upshifts" /id="D1383" /incds=0 /nref=11 /ntot=121 /MaxReadThrough="1.79954" /MaxDrop="4.59487" /score="37.881034" /energy="-13" /TU="NA" /idTUdmin="U2084" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2419157..2419789) /gene="yrhP" /locus_tag="BSU_27100" /old_locus_tag="BSU27100" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16098526, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative amino acid exporter" /protein_id="NP_390588.1" /db_xref="EnsemblGenomes-Gn:BSU27100" /db_xref="EnsemblGenomes-Tr:CAB14652" /db_xref="GOA:O05406" /db_xref="InterPro:IPR001123" /db_xref="InterPro:IPR004778" /db_xref="SubtiList:BG12304" /db_xref="UniProtKB/Swiss-Prot:O05406" /translation="MHSLLAYIPIAAMMVIIPGADTMLVMKNTLRYGPKAGRYNILGL ATGLSFWTVIAILGLSVVIAKSVILFTTIKYLGAAYLIYLGVKSFFAKSMFSLDDMQS QAKNMASSPKRYYKTSFMQGSLSNILNPKTVLVYVTIMPQFINLNGNINQQLIILASI LTLLAVLWFLFLVYIIDYAKKWMKNSKFQKVFQKITGIILVGFGIKTGLS*" /label="yrhP CDS" gene complement(2419157..2419789) /gene="yrhP" /locus_tag="BSU_27100" /old_locus_tag="BSU27100" /label="yrhP gene" downshifts complement(2419213) /Source="Nicolas_upshifts" /id="D1384" /incds=0 /nref=4 /ntot=132 /MaxReadThrough="4.46187" /MaxDrop="3.11632" /score="37.881034" /energy="-13" /TU="U2084" /idTUdmin="U2084" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2419843..2419862) /Source="Nicolas_upshift_promotors" /id="U2084" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.717282717282717" /psig=1 /xcortree=2999 /SigmaFactorBS="tgccttagtaatcgctattttaacaaatcaTATTGATTtatt ccaaacgcatTGATACACTTTTATAAGTAGttacttttgtagtcactatatgattgag g" /listShort="yrhP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2419854) /Source="Nicolas_upshifts" /id="U2084" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.717282717282717" /psig=1 /xcortree=2999 /SigmaFactorBS="tgccttagtaatcgctattttaacaaatcaTATTGATTtatt ccaaacgcatTGATACACTTTTATAAGTAGttacttttgtagtcactatatgattgag g" /listShort="yrhP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2419868..2419874 /Source="Nicolas_upshift_promotors" /id="U2085" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.402597402597403" /psig=1 /xcortree=1861 /SigmaFactorBS="acaaaagtaactacttataaaagtgtatcaatgcgTTTGGAA taaatcaatatgaTTTGTTAAAATAGCGATTACtaaggcagcgattgctctttatatt g" /listShort="yrhO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(2419877..2419884) /Source="Nicolas_upshift_promotors" /id="U2084" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.717282717282717" /psig=1 /xcortree=2999 /SigmaFactorBS="tgccttagtaatcgctattttaacaaatcaTATTGATTtatt ccaaacgcatTGATACACTTTTATAAGTAGttacttttgtagtcactatatgattgag g" /listShort="yrhP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2419888..2419907 /Source="Nicolas_upshift_promotors" /id="U2085" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.402597402597403" /psig=1 /xcortree=1861 /SigmaFactorBS="acaaaagtaactacttataaaagtgtatcaatgcgTTTGGAA taaatcaatatgaTTTGTTAAAATAGCGATTACtaaggcagcgattgctctttatatt g" /listShort="yrhO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2419893 /Source="Nicolas_upshifts" /id="U2085" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.402597402597403" /psig=1 /xcortree=1861 /SigmaFactorBS="acaaaagtaactacttataaaagtgtatcaatgcgTTTGGAA taaatcaatatgaTTTGTTAAAATAGCGATTACtaaggcagcgattgctctttatatt g" /listShort="yrhO" /GFF_Attribute="listLong" /label="upshifts" CDS 2419942..2420769 /gene="yrhO" /locus_tag="BSU_27110" /old_locus_tag="BSU27110" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator controlling amino acid export" /protein_id="NP_390589.1" /db_xref="EnsemblGenomes-Gn:BSU27110" /db_xref="EnsemblGenomes-Tr:CAB14653" /db_xref="InterPro:IPR002831" /db_xref="InterPro:IPR021586" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12303" /db_xref="UniProtKB/Swiss-Prot:O05405" /translation="MKENMLDILKNLNFTEYESKAYLALLQESPLTGYAVAKKSGVPR SKIYEVLESLVIRGDVFVSHGNTPQYVPVPAKELIKNRRLKAEEHFDQAEKYFEKFEQ TANDRENIWNITGRSEILEKVKACILSAKKRILLEIWKEDFKEIEAELKQAAEQGVIV TIIAYGDIVSDFANVYLHDMSSEITEEYDGRWLVYSGDDSEVVAGIVSLGNDSRAAWT MHVGLVMPITEVIIHDLYLMEILKKHRELLEESFGKNLIQLRRKFSIHSDFKKHYLE* " /label="yrhO CDS" gene 2419942..2420769 /gene="yrhO" /locus_tag="BSU_27110" /old_locus_tag="BSU27110" /label="yrhO gene" downshifts 2420765 /Source="Nicolas_upshifts" /id="D1385" /incds=0 /nref=57 /ntot=233 /MaxReadThrough="0.74814" /MaxDrop="5.12635" /score="6.64108595" /energy="-9.5" /TU="NA" /idTUdmin="U2085" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 2420882..2420891 /Source="Nicolas_upshift_promotors" /id="U2086" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.874125874125874" /psig="0.874125874125874" /xcortree=1440 /SigmaFactorBS="tttacttctctcttttaaaaaatgtgattctgcGCAAACTAT TtttcagcctgccGCGTCTATCCTAGGTAacagcctacgatatacgtatattcaaaaa g" /listShort="sigV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2420904..2420919 /Source="Nicolas_upshift_promotors" /id="U2086" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.874125874125874" /psig="0.874125874125874" /xcortree=1440 /SigmaFactorBS="tttacttctctcttttaaaaaatgtgattctgcGCAAACTAT TtttcagcctgccGCGTCTATCCTAGGTAacagcctacgatatacgtatattcaaaaa g" /listShort="sigV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2420909 /Source="Nicolas_upshifts" /id="U2086" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.874125874125874" /psig="0.874125874125874" /xcortree=1440 /SigmaFactorBS="tttacttctctcttttaaaaaatgtgattctgcGCAAACTAT TtttcagcctgccGCGTCTATCCTAGGTAacagcctacgatatacgtatattcaaaaa g" /listShort="sigV" /GFF_Attribute="listLong" /label="upshifts" CDS 2420965..2421465 /gene="sigV" /locus_tag="BSU_27120" /old_locus_tag="BSU27120" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16274938, 21926231, 23687273, 26901131" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16274938, 21926231, 23687273, 26901131; Product type r: regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase ECF(extracytoplasmic function)-type sigma factor (sigma(V))" /protein_id="NP_390590.1" /db_xref="EnsemblGenomes-Gn:BSU27120" /db_xref="EnsemblGenomes-Tr:CAB14654" /db_xref="GOA:O05404" /db_xref="InterPro:IPR000838" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013249" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11974" /db_xref="UniProtKB/Swiss-Prot:O05404" /translation="MKKKQTTKALLVTCITDHKQDFYRLAFSYVKNQDDALDIVQESI KKALSSVETVRNPETIKSWFYKILVRTAIDFLRKQKKIRVMDDETIEFLSKGKEDHYK DTDLHEALDELPYRYKTIIILRFFEDLKLEEIAEITGENTNTVKTRLYRALKLMRIQL TKEDLS*" /label="sigV CDS" gene 2420965..2421465 /gene="sigV" /locus_tag="BSU_27120" /old_locus_tag="BSU27120" /label="sigV gene" CDS 2421465..2422322 /gene="rsiV" /locus_tag="BSU_27130" /old_locus_tag="BSU27130" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16274938, 23687273, 26901131" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16274938, 23687273, 26901131; Product type r: regulator" /codon_start=1 /transl_table=11 /product="anti-sigma(V) factor" /protein_id="NP_390591.1" /db_xref="EnsemblGenomes-Gn:BSU27130" /db_xref="EnsemblGenomes-Tr:CAB14655" /db_xref="GOA:O05403" /db_xref="InterPro:IPR021729" /db_xref="InterPro:IPR025303" /db_xref="InterPro:IPR037126" /db_xref="PDB:5JEN" /db_xref="SubtiList:BG12302" /db_xref="UniProtKB/Swiss-Prot:O05403" /translation="MDKRLQQLREEYKNVQIPKELDIIVEKALQQEPKKKRIVMWPTS AAIAAAILFTALVNINPDAAQAMSKIPVIGKIVKAITFIEIKEEKDQSSIDVKTPALS GLSNKELENSINEKYLKESQQLYKEFIQSTSKNKKGHLSIYSDYETVTDTPDLLSIRR NIETTQASSYTQSRYITIDKKNDILLTLKSLFKDERYIKVISQNIKEQMKQQMKEDPN KIYWLTDEDAEPFKTILPDQTFYITEDHKLVISFDEYEVAPGYMGVTEFTIPTGVISN LLVGERYIR*" /label="rsiV CDS" gene 2421465..2422322 /gene="rsiV" /locus_tag="BSU_27130" /old_locus_tag="BSU27130" /label="rsiV gene" promotor_-10 complement(2422340..2422351) /Source="Nicolas_upshift_promotors" /id="U2087" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.784215784215784" /psig="0.784215784215784" /xcortree=1210 /SigmaFactorBS="atagtatgcaaatattctcgttgtttttgatagcggggttac gacctCGAATAGagaagagagaaaacATCCATAATCTTagatggatgtttttatttta t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2422359) /Source="Nicolas_upshifts" /id="U2087" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.784215784215784" /psig="0.784215784215784" /xcortree=1210 /SigmaFactorBS="atagtatgcaaatattctcgttgtttttgatagcggggttac gacctCGAATAGagaagagagaaaacATCCATAATCTTagatggatgtttttatttta t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2422366..2422372) /Source="Nicolas_upshift_promotors" /id="U2087" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.784215784215784" /psig="0.784215784215784" /xcortree=1210 /SigmaFactorBS="atagtatgcaaatattctcgttgtttttgatagcggggttac gacctCGAATAGagaagagagaaaacATCCATAATCTTagatggatgtttttatttta t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2422433..2424337 /gene="oatA" /locus_tag="BSU_27140" /old_locus_tag="BSU27140" /EC_number="2.3.1.-" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:1521192, 15661003, 21135105, 21586574, 21856855, 21926231" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1521192, 15661003, 21135105, 21586574, 21856855, 21926231; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="peptidoglycan O-acetyltransferase" /protein_id="NP_390592.1" /db_xref="EnsemblGenomes-Gn:BSU27140" /db_xref="EnsemblGenomes-Tr:CAB14656" /db_xref="GOA:O05402" /db_xref="InterPro:IPR002656" /db_xref="InterPro:IPR036514" /db_xref="SubtiList:BG12301" /db_xref="UniProtKB/Swiss-Prot:O05402" /translation="MYHKTQHHRYIPGLDGLRAFAVLSVITYHLNFNWANGGFIGVDI FFVLSGYLITSILLPAYGNDINLDFRDFWVRRIRRLLPAAYLMIFSTVVWVVLFDREL LHTVRGDAISSLFYMSNWWFIFHKLSYFDSFGSPSPLKNLWSLAIEEQFYIIWPMFLV VGMYIMKSRARLAAVISLLVLCSAVMMSVLYEPGGDPSRVYYGTDTRSFELLIGCALA LVWPMKRLSSNRLPSKLKHTLHATEFLAFCILVLCVYFTDEYEPFLYRGGMLFISVTA AILIACVCHPSSFLGNLLSWRPLRWLGTRSYGIYLWHYPVIVLSTPVQEIGNPVFWHI VLKVIVTCILAELSYHFIEKPIRTQGFRSFSRRVFIHRIKEWKTTSVISKMSIGFIIF AILIFAGGLSGLAGEQKHPTKWTYSSQETNADTSQASGDKKNAAADKKHNPEQKTTDS NQGQKENKDSGQETHKKKDTQSQQLKKPADTAKEVLAIGDSVMLDISSHLRQSFSNVT IDGKVGRQMSQALELAREYKSFNQPNKAVIIELGTNGYFTNSQIEQLLQSFSKAHIYL VNTRVPRQWESKVNESLQQQAHAHQNVTLVDWHTEALQHPEYFTPDGVHLVPKGAKTL TALIVQAMKS*" /label="oatA CDS" gene 2422433..2424337 /gene="oatA" /locus_tag="BSU_27140" /old_locus_tag="BSU27140" /label="oatA gene" promotor_-35 2424418..2424424 /Source="Nicolas_upshift_promotors" /id="U2088" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=182 /SigmaFactorBS="gattatgtcttctttcagcaaggcagcccttaTGTTTACatg ccgtttacgtaaGGGTAAGCCAAAATTGAATggagggatgataatgaaaggaaatgaa g" /listShort="yrhK, S1021, S1022" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2424440..2424458 /Source="Nicolas_upshift_promotors" /id="U2088" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=182 /SigmaFactorBS="gattatgtcttctttcagcaaggcagcccttaTGTTTACatg ccgtttacgtaaGGGTAAGCCAAAATTGAATggagggatgataatgaaaggaaatgaa g" /listShort="yrhK, S1021, S1022" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2424446 /Source="Nicolas_upshifts" /id="U2088" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=182 /SigmaFactorBS="gattatgtcttctttcagcaaggcagcccttaTGTTTACatg ccgtttacgtaaGGGTAAGCCAAAATTGAATggagggatgataatgaaaggaaatgaa g" /listShort="yrhK, S1021, S1022" /GFF_Attribute="listLong" /label="upshifts" CDS 2424471..2424761 /gene="yrhK" /locus_tag="BSU_27150" /old_locus_tag="BSU27150" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 21926231" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390593.1" /db_xref="EnsemblGenomes-Gn:BSU27150" /db_xref="EnsemblGenomes-Tr:CAB14657" /db_xref="GOA:O05401" /db_xref="InterPro:IPR025424" /db_xref="SubtiList:BG12300" /db_xref="UniProtKB/Swiss-Prot:O05401" /translation="MKGNEEHDIQKELKRYELFFKKRYKVLYTVNDFIIGAMFLVGSF FFFYDRLMSAGIWLFAIGSLLLLIRPTIRLIHDFHYRKHVEQQFKHQSSTDD*" /label="yrhK CDS" gene 2424471..2424761 /gene="yrhK" /locus_tag="BSU_27150" /old_locus_tag="BSU27150" /label="yrhK gene" S_feature 2424762..2424877 /Source="Nicolas_S_feature" /locus_tag="new_2773647_2773762" /HighExp="Etha, Salt, LPhT, HiTm, G135, LBGstat, G180, G150, Heat, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1021" promotor_-35 2424859..2424866 /Source="Nicolas_upshift_promotors" /id="U2089" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=79 /SigmaFactorBS="gactttcagactatttatttttaaaaacaaggtaaaaagaAC TAAACTtttgcctctgcatGCCGATATGAATAATAAGGccggcgcgatactccctata a" /listShort="S1022" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2424879..2425004 /Source="Nicolas_S_feature" /locus_tag="new_2773764_2773889" /HighExp="Gly, G/S, Lbstat, C90, Pyr, LPhT, LoTm, Etha, T0.30H, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigB" /TUshortPSig="0.998, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1022" upshifts 2424879 /Source="Nicolas_upshifts" /id="U2089" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=79 /SigmaFactorBS="gactttcagactatttatttttaaaaacaaggtaaaaagaAC TAAACTtttgcctctgcatGCCGATATGAATAATAAGGccggcgcgatactccctata a" /listShort="S1022" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2424880..2424898 /Source="Nicolas_upshift_promotors" /id="U2089" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=79 /SigmaFactorBS="gactttcagactatttatttttaaaaacaaggtaaaaagaAC TAAACTtttgcctctgcatGCCGATATGAATAATAAGGccggcgcgatactccctata a" /listShort="S1022" /GFF_Attribute="listLong" /label="promotor_-10" misc_RNA 2424898..2424998 /gene="surF" /locus_tag="BSU_misc_RNA_82" /product="small untranslated RNA expressed under sporulation conditions (SurF-AbrB)" /experiment="publication(s) with functional evidences, PMID:20709900, 25790031" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20709900, 25790031; Product type n: RNA" /label="surF RNA" gene 2424898..2424998 /gene="surF" /locus_tag="BSU_misc_RNA_82" /label="surF gene" downshifts 2424961 /Source="Nicolas_upshifts" /id="D1386" /incds=0 /nref=7 /ntot=129 /MaxReadThrough="3.60641" /MaxDrop="5.24336" /score="25.0079309" /energy="-15.8" /TU="U2089" /idTUdmin="U2088" /TUdmin=16 /isTUend="TRUE" /label="downshifts" CDS complement(2425005..2428169) /gene="cypB" /locus_tag="BSU_27160" /old_locus_tag="BSU27160" /EC_number="1.14.14.1" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11574077, 12775685" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11574077, 12775685; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome P450 CYP102A3" /protein_id="NP_390594.1" /db_xref="EnsemblGenomes-Gn:BSU27160" /db_xref="EnsemblGenomes-Tr:CAB14658" /db_xref="GOA:O08336" /db_xref="InterPro:IPR001094" /db_xref="InterPro:IPR001128" /db_xref="InterPro:IPR001433" /db_xref="InterPro:IPR001709" /db_xref="InterPro:IPR003097" /db_xref="InterPro:IPR008254" /db_xref="InterPro:IPR017927" /db_xref="InterPro:IPR017938" /db_xref="InterPro:IPR017972" /db_xref="InterPro:IPR023206" /db_xref="InterPro:IPR029039" /db_xref="InterPro:IPR036396" /db_xref="SubtiList:BG12299" /db_xref="UniProtKB/Swiss-Prot:O08336" /translation="MKQASAIPQPKTYGPLKNLPHLEKEQLSQSLWRIADELGPIFRF DFPGVSSVFVSGHNLVAEVCDEKRFDKNLGKGLQKVREFGGDGLFTSWTHEPNWQKAH RILLPSFSQKAMKGYHSMMLDIATQLIQKWSRLNPNEEIDVADDMTRLTLDTIGLCGF NYRFNSFYRDSQHPFITSMLRALKEAMNQSKRLGLQDKMMVKTKLQFQKDIEVMNSLV DRMIAERKANPDENIKDLLSLMLYAKDPVTGETLDDENIRYQIITFLIAGHETTSGLL SFAIYCLLTHPEKLKKAQEEADRVLTDDTPEYKQIQQLKYIRMVLNETLRLYPTAPAF SLYAKEDTVLGGEYPISKGQPVTVLIPKLHRDQNAWGPDAEDFRPERFEDPSSIPHHA YKPFGNGQRACIGMQFALQEATMVLGLVLKHFELINHTGYELKIKEALTIKPDDFKIT VKPRKTAAINVQRKEQADIKAETKPKETKPKHGTPLLVLFGSNLGTAEGIAGELAAQG RQMGFTAETAPLDDYIGKLPEEGAVVIVTASYNGAPPDNAAGFVEWLKELEEGQLKGV SYAVFGCGNRSWASTYQRIPRLIDDMMKAKGASRLTAIGEGDAADDFESHRESWENRF WKETMDAFDINEIAQKEDRPSLSITFLSEATETPVAKAYGAFEGIVLENRELQTAAST RSTRHIELEIPAGKTYKEGDHIGILPKNSRELVQRVLSRFGLQSNHVIKVSGSAHMAH LPMDRPIKVVDLLSSYVELQEPASRLQLRELASYTVCPPHQKELEQLVSDDGIYKEQV LAKRLTMLDFLEDYPACEMPFERFLALLPSLKPRYYSISSSPKVHANIVSMTVGVVKA SAWSGRGEYRGVASNYLAELNTGDAAACFIRTPQSGFQMPNDPETPMIMVGPGTGIAP FRGFIQARSVLKKEGSTLGEALLYFGCRRPDHDDLYREELDQAEQDGLVTIRRCYSRV ENEPKGYVQHLLKQDTQKLMTLIEKGAHIYVCGDGSQMAPDVERTLRLAYEAEKAASQ EESAVWLQKLQDQRRYVKDVWTGM*" /label="cypB CDS" gene complement(2425005..2428169) /gene="cypB" /locus_tag="BSU_27160" /old_locus_tag="BSU27160" /label="cypB gene" downshifts complement(2425021) /Source="Nicolas_upshifts" /id="D1387" /incds=0 /nref=25 /ntot=213 /MaxReadThrough="2.3596" /MaxDrop="4.0425" /score="-9.99429269" /energy="-17.6" /TU="NA" /idTUdmin="U2091" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 2426155..2426164 /Source="Nicolas_upshift_promotors" /id="U2090" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1249 /SigmaFactorBS="ctggagttctcgattcTCTAACACAAtcccttcaaacgcGCC ATATGCTTTAGCAACCGgcgtttccgtcgcttcactgagaaaagtaatcgataatgaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2426178..2426197 /Source="Nicolas_upshift_promotors" /id="U2090" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1249 /SigmaFactorBS="ctggagttctcgattcTCTAACACAAtcccttcaaacgcGCC ATATGCTTTAGCAACCGgcgtttccgtcgcttcactgagaaaagtaatcgataatgaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2426199 /Source="Nicolas_upshifts" /id="U2090" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1249 /SigmaFactorBS="ctggagttctcgattcTCTAACACAAtcccttcaaacgcGCC ATATGCTTTAGCAACCGgcgtttccgtcgcttcactgagaaaagtaatcgataatgaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2428185..2428769) /gene="bscR" /locus_tag="BSU_27170" /old_locus_tag="BSU27170" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11574077" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11574077; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator for cypB" /protein_id="NP_390595.1" /db_xref="EnsemblGenomes-Gn:BSU27170" /db_xref="EnsemblGenomes-Tr:CAB14659" /db_xref="GOA:O08335" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR023772" /db_xref="InterPro:IPR032551" /db_xref="SubtiList:BG12298" /db_xref="UniProtKB/Swiss-Prot:O08335" /translation="MISASSSKYDMIMKASVSLFTERGFDATTIPMIAERAHVGTGTI YRYFDSKETLVNVLFQESIQRFTEKLKQDVSELPVREGFHHVFCCLVQFTKESDYALF FLETKKDAHYLNHTSKKMIENLTQMLDDYFNKGKAEGVIRSLPSNVLIAIVLGAFLKI YQLVQTGDIEMDTDLITELEQCCWDAIKLHSSQK*" /label="bscR CDS" gene complement(2428185..2428769) /gene="bscR" /locus_tag="BSU_27170" /old_locus_tag="BSU27170" /label="bscR gene" CDS complement(2428992..2429534) /gene="yrhH" /locus_tag="BSU_27180" /old_locus_tag="BSU27180" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15870467; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative methyltransferase" /protein_id="NP_390596.1" /db_xref="EnsemblGenomes-Gn:BSU27180" /db_xref="EnsemblGenomes-Tr:CAB14660" /db_xref="GOA:O05400" /db_xref="InterPro:IPR013216" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG12297" /db_xref="UniProtKB/Swiss-Prot:O05400" /translation="MLENRLYKRSDFWKLFSRKYKLTKTIEHMMIDSIDIQENDRILE IGIGNGTVFKSITKKLKKGSLKSIDPSKRKVRQISRANRKNMGNGEVFHGYPEDIPFD DRTFNKVFSLHTVQSCTDIRLALREIYRVLQIDGRFYISIDTNTGEKEKTYIQLLKDQ HFRDLSVIRRASCLCIVAVK*" /label="yrhH CDS" gene complement(2428992..2429534) /gene="yrhH" /locus_tag="BSU_27180" /old_locus_tag="BSU27180" /label="yrhH gene" S_feature complement(2429535..2429620) /Source="Nicolas_S_feature" /locus_tag="new_2778420_2778505_c" /HighExp="T-0.40H, Salt, T0.30H, Heat, T0.0H, Etha, T-1.10H, T-1.40H, T1.0H, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY, SigA" /TUshortPSig="1, 0.998" /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S1023" promotor_-10 complement(2429618..2429633) /Source="Nicolas_upshift_promotors" /id="U2091" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1647 /SigmaFactorBS="aaaaaatgaaaaagtttagttctatTGAAACATTTttcaata cattgCCGTCTAGTTGGTACCttccttcacttttagaaatgaagatgatgtttatttt t" /listShort="S1023, yrhH, bscR, cypB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2429620) /Source="Nicolas_upshifts" /id="U2091" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1647 /SigmaFactorBS="aaaaaatgaaaaagtttagttctatTGAAACATTTttcaata cattgCCGTCTAGTTGGTACCttccttcacttttagaaatgaagatgatgtttatttt t" /listShort="S1023, yrhH, bscR, cypB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2429646..2429655) /Source="Nicolas_upshift_promotors" /id="U2091" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1647 /SigmaFactorBS="aaaaaatgaaaaagtttagttctatTGAAACATTTttcaata cattgCCGTCTAGTTGGTACCttccttcacttttagaaatgaagatgatgtttatttt t" /listShort="S1023, yrhH, bscR, cypB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2429689..2429905) /Source="Nicolas_S_feature" /locus_tag="new_2778574_2778790_c" /HighExp="S7, S8, S6, LPhT, BT, LBGstat, S5, B36, G/S, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99909999999999999" /TUshortSig="SigK, SigA" /TUshortPSig="0.999, 0.998" /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S1024" CDS complement(2429723..2429881) /locus_tag="BSU_27185" /old_locus_tag="BSU27185" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513991.1" /translation="MMNDYQKRLPSIGHGYASMPHSFKHGYGNPFRQQRLMAMQQQRL YVFPYHWH*" /label="hypothetical protein CDS" gene complement(2429723..2429881) /locus_tag="BSU_27185" /old_locus_tag="BSU27185" /label="gene" downshifts complement(2429732) /Source="Nicolas_upshifts" /id="D1388" /incds=0 /nref=34 /ntot=184 /MaxReadThrough="3.04168" /MaxDrop="7.65849" /score="23.6695072" /energy="-11.3" /TU="U2093" /idTUdmin="U2092" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2429903..2429922) /Source="Nicolas_upshift_promotors" /id="U2092" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1229 /SigmaFactorBS="aaggaccaagtttagcgaaaTAGCTGTCAAgaaaatgcgcgc cTGCATATAGTAAATCAACGTtattgtgaggcaggtgatggcatgatgaacgattatc a" /listShort="S1024" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2429905) /Source="Nicolas_upshifts" /id="U2092" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1229 /SigmaFactorBS="aaggaccaagtttagcgaaaTAGCTGTCAAgaaaatgcgcgc cTGCATATAGTAAATCAACGTtattgtgaggcaggtgatggcatgatgaacgattatc a" /listShort="S1024" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2429907..2430037) /Source="Nicolas_S_feature" /locus_tag="new_2778792_2778922_c" /HighExp="S7, S8, LPhT, S6, LBGstat, B36, BT, S5, Cold, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.893648" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S1025" promotor_-35 complement(2429936..2429945) /Source="Nicolas_upshift_promotors" /id="U2092" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1229 /SigmaFactorBS="aaggaccaagtttagcgaaaTAGCTGTCAAgaaaatgcgcgc cTGCATATAGTAAATCAACGTtattgtgaggcaggtgatggcatgatgaacgattatc a" /listShort="S1024" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2430038..2430187) /gene="yrzI" /locus_tag="BSU_27190" /old_locus_tag="BSU27190" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390597.1" /db_xref="EnsemblGenomes-Gn:BSU27190" /db_xref="EnsemblGenomes-Tr:CAB14661" /db_xref="InterPro:IPR012655" /db_xref="SubtiList:BG13819" /db_xref="UniProtKB/Swiss-Prot:O32027" /translation="MTINLFFLTLTIKKRFKSLEEFEREQQIEQIYDEMKESQLKHLY LTNWR*" /label="yrzI CDS" gene complement(2430038..2430187) /gene="yrzI" /locus_tag="BSU_27190" /old_locus_tag="BSU27190" /label="yrzI gene" downshifts 2430181 /Source="Nicolas_upshifts" /id="D1389" /incds=0 /nref=4 /ntot=35 /MaxReadThrough="1.96539" /MaxDrop="3.70444" /score="-6.5827622" /energy="-7.8" /TU="NA" /idTUdmin="U2089" /TUdmin=4972 /isTUend="FALSE" /label="downshifts" S_feature complement(2430188..2430278) /Source="Nicolas_S_feature" /locus_tag="new_2779073_2779163_c" /HighExp="S7, LBGstat, Cold, S6, B36, LPhT, T-0.40H, LoTm, S8, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S1026" S_feature complement(2430280..2430499) /Source="Nicolas_S_feature" /locus_tag="new_2779165_2779384_c" /HighExp="B60, B36, S7, BT, LBGstat, Cold, LoTm, LPhT, S6, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.52109300000000003" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S1027" downshifts complement(2430323) /Source="Nicolas_upshifts" /id="D1390" /incds=0 /nref=2 /ntot=37 /MaxReadThrough="7.23426" /MaxDrop="3.6023" /score="11.9275075" /energy="-19.6" /TU="U2093,U2094" /idTUdmin="U2094" /TUdmin="-440" /isTUend="FALSE" /label="downshifts" downshifts 2430445 /Source="Nicolas_upshifts" /id="D1391" /incds=0 /nref=16 /ntot=94 /MaxReadThrough="0.94778" /MaxDrop="4.28987" /score="-6.5827622" /energy="-7.8" /TU="NA" /idTUdmin="U2089" /TUdmin=5236 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2430478..2430497) /Source="Nicolas_upshift_promotors" /id="U2093" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.984015984015984" /psig="0.998001998001998" /xcortree=590 /SigmaFactorBS="tcgatgatttgcacaatttccgtccatttttagaaaaagaTG TTTACAaaatggaatttggtGGATATACTTACAAAGTAAGaaaaaagcaaaggaggct g" /listShort="S1027, S1026, yrzI, S1025, S1024, S1023, yrhH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2430499) /Source="Nicolas_upshifts" /id="U2093" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.984015984015984" /psig="0.998001998001998" /xcortree=590 /SigmaFactorBS="tcgatgatttgcacaatttccgtccatttttagaaaaagaTG TTTACAaaatggaatttggtGGATATACTTACAAAGTAAGaaaaaagcaaaggaggct g" /listShort="S1027, S1026, yrzI, S1025, S1024, S1023, yrhH" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2430501..2430576) /Source="Nicolas_S_feature" /locus_tag="new_2779386_2779461_c" /HighExp="Lbexp, dia0, dia5, G150, Cold, C30, Mt0, LBGexp, dia15, Etha" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.115567" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1028" promotor_-35 complement(2430512..2430519) /Source="Nicolas_upshift_promotors" /id="U2093" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.984015984015984" /psig="0.998001998001998" /xcortree=590 /SigmaFactorBS="tcgatgatttgcacaatttccgtccatttttagaaaaagaTG TTTACAaaatggaatttggtGGATATACTTACAAAGTAAGaaaaaagcaaaggaggct g" /listShort="S1027, S1026, yrzI, S1025, S1024, S1023, yrhH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2430577..2431377) /gene="yrhG" /locus_tag="BSU_27200" /old_locus_tag="BSU27200" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 24887098; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative formate/nitrite transporter" /protein_id="NP_390598.1" /db_xref="EnsemblGenomes-Gn:BSU27200" /db_xref="EnsemblGenomes-Tr:CAB14662" /db_xref="GOA:O05399" /db_xref="InterPro:IPR000292" /db_xref="InterPro:IPR023271" /db_xref="InterPro:IPR024002" /db_xref="SubtiList:BG12296" /db_xref="UniProtKB/Swiss-Prot:O05399" /translation="MAFRKPDEIAEAAIEAGMKKIKLPLPSLLVLGFLGGAFIALGYL LDIRVIGDLPKEWGSLSSLIGAAVFPVGLILVVLAGAELITGNMMSVAMALFSRKISV KELAINWGIVTIMNLIGALFVAYFFGHLVGLTETGPYLEKTIAVAQGKLDMSFGKVLI SAIGCNWLVCLAVWLSFGAQDAAGKILGIWFPIMAFVAIGFQHVVANMFVIPAAIFAG SFTWGQFIGNIIPAFIGNVIGGAVFVGLIYFIAYHKKDRSRKEMKQVS*" /label="yrhG CDS" gene complement(2430577..2431377) /gene="yrhG" /locus_tag="BSU_27200" /old_locus_tag="BSU27200" /label="yrhG gene" S_feature complement(2431446..2431599) /Source="Nicolas_S_feature" /locus_tag="new_2780331_2780484_c" /HighExp="Lbexp, dia0, dia5, Cold, G150, Etha, HiOs, Salt, C90, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1029" downshifts complement(2431489) /Source="Nicolas_upshifts" /id="D1392" /incds=0 /nref=1 /ntot=70 /MaxReadThrough="6.01922" /MaxDrop="3.7673" /score="23.461824" /energy="-25" /TU="U2094,U2095" /idTUdmin="U2095" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2431590..2431609) /Source="Nicolas_upshift_promotors" /id="U2094" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.418581418581419" /psig=1 /xcortree=111 /SigmaFactorBS="aagaagctctgcaaagctagtatatttgtCATTGACacaaat ttgtcacaTTTGATATGATGTTGCTACAgttatagaaggctaaagcaatggaatgtat g" /listShort="S1029, yrhG, S1028, S1027, S1026, yrzI, S1025" /listLong="S1024, S1023, yrhH" /label="promotor_-10" upshifts complement(2431599) /Source="Nicolas_upshifts" /id="U2094" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.418581418581419" /psig=1 /xcortree=111 /SigmaFactorBS="aagaagctctgcaaagctagtatatttgtCATTGACacaaat ttgtcacaTTTGATATGATGTTGCTACAgttatagaaggctaaagcaatggaatgtat g" /listShort="S1029, yrhG, S1028, S1027, S1026, yrzI, S1025" /listLong="S1024, S1023, yrhH" /label="upshifts" promotor_-35 complement(2431624..2431630) /Source="Nicolas_upshift_promotors" /id="U2094" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.418581418581419" /psig=1 /xcortree=111 /SigmaFactorBS="aagaagctctgcaaagctagtatatttgtCATTGACacaaat ttgtcacaTTTGATATGATGTTGCTACAgttatagaaggctaaagcaatggaatgtat g" /listShort="S1029, yrhG, S1028, S1027, S1026, yrzI, S1025" /listLong="S1024, S1023, yrhH" /label="promotor_-35" CDS complement(2431640..2432008) /gene="yrhF" /locus_tag="BSU_27210" /old_locus_tag="BSU27210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390599.1" /db_xref="EnsemblGenomes-Gn:BSU27210" /db_xref="EnsemblGenomes-Tr:CAB14663" /db_xref="InterPro:IPR018745" /db_xref="SubtiList:BG12295" /db_xref="UniProtKB/Swiss-Prot:O05398" /translation="MSKKIHEFNDIIRKLRKELFGKGPERIHTVFVENMAVSTLYGNL SASEQFIARTPEGREMVHAARTSLIQDLYSKQTPEGMEELMGAKLVHLFSDIKIEENI AVSVFVFDRKIDEQKEALQS*" /label="yrhF CDS" gene complement(2431640..2432008) /gene="yrhF" /locus_tag="BSU_27210" /old_locus_tag="BSU27210" /label="yrhF gene" S_feature complement(2432009..2432105) /Source="Nicolas_S_feature" /locus_tag="new_2780894_2780990_c" /HighExp="T0.30H, LBGstat, T1.0H, T1.30H, G150, Lbexp, dia0, G180, M9-stat, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1030" promotor_-10 complement(2432091..2432110) /Source="Nicolas_upshift_promotors" /id="U2095" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.908091908091908" /psig=1 /xcortree=2748 /SigmaFactorBS="atagactcataacaagatcctattacaaatccatcaacactG CTTTtattataatgtgataTTTATTATAATACAATATGGcaggaaaattttaaccaag t" /listShort="S1030, yrhF, S1029" /listLong="yrhG, S1028, S1027, S1026, yrzI, S1025, S1024, S1023, yrhH" /label="promotor_-10" promotor_-35 2432095..2432098 /Source="Nicolas_upshift_promotors" /id="U2096" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.412587412587413" /psig=1 /xcortree=2755 /SigmaFactorBS="ccctcaggacatttcacttggttaaaattttcctgccatATT GtattataataaatatCACATTATAATAAAAGCAGTgttgatggatttgtaataggat c" /listShort="S1031, yrhE, yrhD" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2432111) /Source="Nicolas_upshifts" /id="U2095" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.908091908091908" /psig=1 /xcortree=2748 /SigmaFactorBS="atagactcataacaagatcctattacaaatccatcaacactG CTTTtattataatgtgataTTTATTATAATACAATATGGcaggaaaattttaaccaag t" /listShort="S1030, yrhF, S1029" /listLong="yrhG, S1028, S1027, S1026, yrzI, S1025, S1024, S1023, yrhH" /label="upshifts" promotor_-10 2432114..2432133 /Source="Nicolas_upshift_promotors" /id="U2096" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.412587412587413" /psig=1 /xcortree=2755 /SigmaFactorBS="ccctcaggacatttcacttggttaaaattttcctgccatATT GtattataataaatatCACATTATAATAAAAGCAGTgttgatggatttgtaataggat c" /listShort="S1031, yrhE, yrhD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2432116 /Source="Nicolas_upshifts" /id="U2096" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.412587412587413" /psig=1 /xcortree=2755 /SigmaFactorBS="ccctcaggacatttcacttggttaaaattttcctgccatATT GtattataataaatatCACATTATAATAAAAGCAGTgttgatggatttgtaataggat c" /listShort="S1031, yrhE, yrhD" /GFF_Attribute="listLong" /label="upshifts" S_feature 2432117..2432323 /Source="Nicolas_S_feature" /locus_tag="new_2781002_2781208" /HighExp="G150, Lbexp, dia0, Cold, dia5, G135, LBGstat, LBGexp, G180, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1031" promotor_-35 complement(2432126..2432130) /Source="Nicolas_upshift_promotors" /id="U2095" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.908091908091908" /psig=1 /xcortree=2748 /SigmaFactorBS="atagactcataacaagatcctattacaaatccatcaacactG CTTTtattataatgtgataTTTATTATAATACAATATGGcaggaaaattttaaccaag t" /listShort="S1030, yrhF, S1029" /listLong="yrhG, S1028, S1027, S1026, yrzI, S1025, S1024, S1023, yrhH" /label="promotor_-35" CDS 2432324..2435266 /gene="yrhE" /locus_tag="BSU_27220" /old_locus_tag="BSU27220" /EC_number="1.17.1.9" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10913079, 19114526; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative formate dehydrogenase" /protein_id="NP_390600.1" /db_xref="EnsemblGenomes-Gn:BSU27220" /db_xref="EnsemblGenomes-Tr:CAB14664" /db_xref="GOA:Q795Y4" /db_xref="InterPro:IPR001041" /db_xref="InterPro:IPR006478" /db_xref="InterPro:IPR006656" /db_xref="InterPro:IPR006657" /db_xref="InterPro:IPR006963" /db_xref="InterPro:IPR009010" /db_xref="InterPro:IPR009051" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR017896" /db_xref="InterPro:IPR017900" /db_xref="InterPro:IPR019574" /db_xref="InterPro:IPR036010" /db_xref="SubtiList:BG12294" /db_xref="UniProtKB/Swiss-Prot:Q795Y4" /translation="MMDVKSISVRVDGTEIQARAGATILDILNENGIEYPQICHVPEV DPIQTCDTCIVEANGKLVRSCATVAENGMSIDLSGNRVKEAQTEAMDRLLENHLLYCT VCDNNNGNCTLHNTAEMMGIEHQKYPYTPKEDPSCAVDMSHPFYRYDPNQCIACGQCV EVCQNLQVNETLSIDWERERPRVIWDEGVPINESSCVSCGQCVTVCPCNALMEKSMLG QAGFMTGIKEDVMEPMIDLVKNVEPGYGSIFAISEVEAAMRETRTKKTKTVCTFCGVG CSFEVWTKGRDILKIQPVSDAPVNAISTCVKGKFGWDFVNSKERITKPLIRKNGAFVE SSWEEALDLVASRLGSIKEQYGKGSVGFISSSKITNEENYVIQKLARQVFETNNVDNC SRYCQSPATDGLFRTVGMGGDAGTIKDIAKAGLVIIVGANPAEGHPVLATRVKRAHKL HGQKLIVADLRKNEMAERSDLFISPKQGTDQVWLMAVTKYMIDQGWHDQAFIDENVNY FEDYKETLKTYTLDYAERITGLSKENIIQIAEMIRDADGTCVLWGMGVTQNTGGSDTS AAISNLLLATGNYRRPGAGAYPLRGHNNVQGACDMGTLPGWLPGYQHITDDKARAKFE EAYGVEIDGKPGLDNIQMLHAIEEGKMKAMYLVGEDMALVDSNANHVHDILSSLDFFV VQDIFLSRTAQYADVVLPATPSLEKDGTFTNTERRVQRLYQALPTLGDAKPDWWIIQE VANRLGANWNYSHPSDIFSEMASLSPLFAKASYEVLEGWNSFLWGSFTGESTPLLYED GFNFPDKKARFALSDWTEPAAFPEEYDLHINNGRMLEHFHEGNMTNKSKGIQAKVPNV FVEISPELAQERGVCDGSLVRLVSPFGAVKLNALITDRVRKNELYLPMNSTDKESAIN FLTGPAADKRTNTPAYKQTKVRMEVLGGCETAPLPKTNPRNKKRHPQNGVEAERKWNR PGYVHLTD*" /label="yrhE CDS" gene 2432324..2435266 /gene="yrhE" /locus_tag="BSU_27220" /old_locus_tag="BSU27220" /label="yrhE gene" CDS 2435285..2435767 /gene="yrhD" /locus_tag="BSU_27230" /old_locus_tag="BSU27230" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 10913079" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390601.1" /db_xref="EnsemblGenomes-Gn:BSU27230" /db_xref="EnsemblGenomes-Tr:CAB14665" /db_xref="InterPro:IPR012440" /db_xref="SubtiList:BG12293" /db_xref="UniProtKB/Swiss-Prot:O05396" /translation="MATPITTIKKETKTAEQIKLEKIEELKELLAENEDAVSKTMTLM NELNDLGIFDAATSMLRAKEDIAKIALGQVSREPVTNLINTMMAAGGALTKADPEFTA KLLESVMAGTEQAQSFLKEDKKVGILDLLKAMNDPDINRAVGFGLQFLKGMGKELREQ *" /label="yrhD CDS" gene 2435285..2435767 /gene="yrhD" /locus_tag="BSU_27230" /old_locus_tag="BSU27230" /label="yrhD gene" downshifts 2435747 /Source="Nicolas_upshifts" /id="D1393" /incds=0 /nref=65 /ntot=196 /MaxReadThrough="1.1227" /MaxDrop="6.19465" /score="27.8496451" /energy="-11.2" /TU="NA" /idTUdmin="U2096" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2435803..2436033) /gene="yrhC" /locus_tag="BSU_27240" /old_locus_tag="BSU27240" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 17056751" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390602.1" /db_xref="EnsemblGenomes-Gn:BSU27240" /db_xref="EnsemblGenomes-Tr:CAB14666" /db_xref="GOA:O05395" /db_xref="InterPro:IPR025418" /db_xref="SubtiList:BG12292" /db_xref="UniProtKB/Swiss-Prot:O05395" /translation="MNKNRMKSLKEDYKHFAFTLLAVSTFLYIGAVLPDQGLTLGQKS TMFLADCVFLAGAFFCADRSLIYKKRLEEADE*" /label="yrhC CDS" gene complement(2435803..2436033) /gene="yrhC" /locus_tag="BSU_27240" /old_locus_tag="BSU27240" /label="yrhC gene" downshifts complement(2435823) /Source="Nicolas_upshifts" /id="D1394" /incds=0 /nref=60 /ntot=210 /MaxReadThrough="0.98344" /MaxDrop="5.84379" /score="15.2557797" /energy="-11.2" /TU="NA" /idTUdmin="U2097" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2436034..2436115) /Source="Nicolas_S_feature" /locus_tag="new_2784919_2785000_c" /HighExp="dia5, dia15, BT, Diami, B36, B60, nit, dia0, MG 10, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA, SigA" /TUshortPSig="1, 0.999, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1032" CDS complement(2436116..2437255) /gene="mccB" /locus_tag="BSU_27250" /old_locus_tag="BSU27250" /EC_number="4.4.1.2" /EC_number="4.4.1.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 15760717, 17056751, 18812398" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 15760717, 17056751, 18812398; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cystathionine gamma-lyase and homocysteine gamma-lyase for reverse transsulfuration pathway" /protein_id="NP_390603.1" /db_xref="EnsemblGenomes-Gn:BSU27250" /db_xref="EnsemblGenomes-Tr:CAB14667" /db_xref="GOA:O05394" /db_xref="InterPro:IPR000277" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG12291" /db_xref="UniProtKB/Swiss-Prot:O05394" /translation="MKKKTLMIHGGITGDEKTGAVSVPIYQVSTYKQPKAGQHTGYEY SRTANPTRTALEALVTELESGEAGYAFSSGMAAITAVMMLFNSGDHVVLTDDVYGGTY RVMTKVLNRLGIESTFVDTSSREEVEKAIRPNTKAIYIETPTNPLLKITDLTLMADIA KKAGVLLIVDNTFNTPYFQQPLTLGADIVLHSATKYLGGHSDVVGGLVVTASKELGEE LHFVQNSTGGVLGPQDSWLLMRGIKTLGLRMEAIDQNARKIASFLENHPAVQTLYYPG SSNHPGHELAKTQGAGFGGMISFDIGSEERVDAFLGNLKLFTIAESLGAVESLISVPA RMTHASIPRERRLELGITDGLIRISVGIEDAEDLLEDIGQALENI*" /label="mccB CDS" gene complement(2436116..2437255) /gene="mccB" /locus_tag="BSU_27250" /old_locus_tag="BSU27250" /label="mccB gene" CDS complement(2437257..2438180) /gene="mccA" /locus_tag="BSU_27260" /old_locus_tag="BSU27260" /EC_number="2.5.1.47" /EC_number="4.2.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 15760717, 17056751, 18812398" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 15760717, 17056751, 18812398; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cystathionine beta-synthase for the reverse transsulfuration pathway" /protein_id="NP_390604.1" /db_xref="EnsemblGenomes-Gn:BSU27260" /db_xref="EnsemblGenomes-Tr:CAB14668" /db_xref="GOA:O05393" /db_xref="InterPro:IPR001216" /db_xref="InterPro:IPR001926" /db_xref="InterPro:IPR036052" /db_xref="SubtiList:BG12290" /db_xref="UniProtKB/Swiss-Prot:O05393" /translation="MTVITDITELIGNTPLLRLKNFDVPEGVAVYAKLEMMNPGGSIK DRLGDMLIRDALDSGKVKPGGVIIEATAGNTGIGLALSARKYGLKAIFCVPEHFSREK QQIMQALGASIIHTPRQDGMQGAIQKAIQLETEIENSYCVLQFKNRVNPSTYYKTLGP EMWEALDGNIHTFVAGAGSGGTFAGTASFLKEKNPAVKTVIVEPVGSILNGGEPHAHK TEGIGMEFIPDYMDKSHFDEIYTVTDENAFRLVKEAAEKEGLLIGSSSGAALYAALEE AKKASAGTNIVTVFPDSSDRYISKQIYEGGI*" /label="mccA CDS" gene complement(2437257..2438180) /gene="mccA" /locus_tag="BSU_27260" /old_locus_tag="BSU27260" /label="mccA gene" downshifts complement(2438173) /Source="Nicolas_upshifts" /id="D1395" /incds=0 /nref=16 /ntot=178 /MaxReadThrough="7.13056" /MaxDrop="3.40819" /score="0.994445584" /energy="-8.7" /TU="U2097,U2098,U2099" /idTUdmin="U2102" /TUdmin=1874 /isTUend="FALSE" /label="downshifts" S_feature complement(2438181..2438244) /Source="Nicolas_S_feature" /locus_tag="new_2787066_2787129_c" /HighExp="dia5, Diami, dia15, BT, B36, S6, LBGstat, S8, dia0, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA, SigA" /TUshortPSig="1, 0.999, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1033" CDS complement(2438245..2438940) /gene="mtnN" /locus_tag="BSU_27270" /old_locus_tag="BSU27270" /EC_number="3.2.2.9" /EC_number="3.2.2.16" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10574451, 10939241, 15102328, 17056751, 24509311, 25849497, 25849889" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10574451, 10939241, 15102328, 17056751, 24509311, 25849497, 25849889; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylthioadenosine / S-adenosylhomocysteine nucleosidase" /protein_id="NP_390605.1" /db_xref="EnsemblGenomes-Gn:BSU27270" /db_xref="EnsemblGenomes-Tr:CAB14669" /db_xref="GOA:O32028" /db_xref="InterPro:IPR000845" /db_xref="InterPro:IPR010049" /db_xref="InterPro:IPR035994" /db_xref="SubtiList:BG13800" /db_xref="UniProtKB/Swiss-Prot:O32028" /translation="MRLAVIGAMEEEVTILRNKLENAKTETIAHCEFTTGEYEGTEVI LLKSGIGKVNAAISTTLLLDRYKPDYVINTGSAGGFHHTLNVGDVVISTDVRHHDVDV TAFDYEYGQVPGLPAAYAADEKLISITEEAVSELDGIQVAKGTIATGDSFMNDPKRVE EVRARFSDLYAVEMEAAAVAQVCHQFKTPFVVIRALSDIAGKESHVSFDQFLEQAAVH STELVLKVIKRIH*" /label="mtnN CDS" gene complement(2438245..2438940) /gene="mtnN" /locus_tag="BSU_27270" /old_locus_tag="BSU27270" /label="mtnN gene" promotor_-10 complement(2438680..2438699) /Source="Nicolas_upshift_promotors" /id="U2097" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1315 /SigmaFactorBS="tctgcttgaccgttacaagcctgattatgtcattaacACAGG CTCAGccggcggatttcATCATACATTGAATGTAGGGgatgtcgtcatttccactgac g" /listShort="S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2438698) /Source="Nicolas_upshifts" /id="U2097" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1315 /SigmaFactorBS="tctgcttgaccgttacaagcctgattatgtcattaacACAGG CTCAGccggcggatttcATCATACATTGAATGTAGGGgatgtcgtcatttccactgac g" /listShort="S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2438712..2438721) /Source="Nicolas_upshift_promotors" /id="U2097" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1315 /SigmaFactorBS="tctgcttgaccgttacaagcctgattatgtcattaacACAGG CTCAGccggcggatttcATCATACATTGAATGTAGGGgatgtcgtcatttccactgac g" /listShort="S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2438961..2439602) /gene="yrrT" /locus_tag="BSU_27280" /old_locus_tag="BSU27280" /EC_number="2.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10939241, 17056751; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative AdoMet-dependent methyltransferase" /protein_id="NP_390606.1" /db_xref="EnsemblGenomes-Gn:BSU27280" /db_xref="EnsemblGenomes-Tr:CAB14670" /db_xref="GOA:O32029" /db_xref="InterPro:IPR001737" /db_xref="InterPro:IPR020598" /db_xref="InterPro:IPR023553" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG13799" /db_xref="UniProtKB/Swiss-Prot:O32029" /translation="MGREFIPLFEDWAATYDQTVQGLDIQYKEAFRGYDHILDAIVRK SGTHVLEFGPGTGNLTAKLLDAGKTVFGIEPSPAMRKLASDKLSGRTEIVDGDFLTFP EPPFQADTIVSSYAFHHLTDEEKRAAIKQYGKYLHLHDKIVFADTVFENAQAYQQAID KARSQGFYQLANDLETEHYPTLDALKEMFTAEGFAVRFTQQNDFVWIMEAIKR*" /label="yrrT CDS" gene complement(2438961..2439602) /gene="yrrT" /locus_tag="BSU_27280" /old_locus_tag="BSU27280" /label="yrrT gene" promotor_-10 complement(2439169..2439188) /Source="Nicolas_upshift_promotors" /id="U2098" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.498501498501498" /psig="0.999000999001" /xcortree=2663 /SigmaFactorBS="catttgactgacgaagaaaagcgggctgccataaagcaatAT GGcaaataccttcacttgCATGATAAAATAGTGTTTGCcgataccgtctttgaaaatg c" /listShort="mtnN, S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2439188) /Source="Nicolas_upshifts" /id="U2098" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.498501498501498" /psig="0.999000999001" /xcortree=2663 /SigmaFactorBS="catttgactgacgaagaaaagcgggctgccataaagcaatAT GGcaaataccttcacttgCATGATAAAATAGTGTTTGCcgataccgtctttgaaaatg c" /listShort="mtnN, S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2439205..2439208) /Source="Nicolas_upshift_promotors" /id="U2098" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.498501498501498" /psig="0.999000999001" /xcortree=2663 /SigmaFactorBS="catttgactgacgaagaaaagcgggctgccataaagcaatAT GGcaaataccttcacttgCATGATAAAATAGTGTTTGCcgataccgtctttgaaaatg c" /listShort="mtnN, S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2439654..2439663 /Source="Nicolas_upshift_promotors" /id="U2100" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=1274 /SigmaFactorBS="taattcctataagtatactatggattaatGATGGAACAGttc ctataatacCACATATTCTGAAAAGCAGGtactaaaacactttgtgtattttatgcca t" /listShort="S1034, yrzA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2439660..2439679) /Source="Nicolas_upshift_promotors" /id="U2099" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.436563436563437" /psig="0.998001998001998" /xcortree=1746 /SigmaFactorBS="gatggcataaaatacacaaagtgttttaGTACctgcttttca gaataTGTGGTATTATAGGAACTGTtccatcattaatccatagtatacttataggaat t" /listShort="yrrT, mtnN, S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2439666) /Source="Nicolas_upshifts" /id="U2099" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.436563436563437" /psig="0.998001998001998" /xcortree=1746 /SigmaFactorBS="gatggcataaaatacacaaagtgttttaGTACctgcttttca gaataTGTGGTATTATAGGAACTGTtccatcattaatccatagtatacttataggaat t" /listShort="yrrT, mtnN, S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2439676..2439695 /Source="Nicolas_upshift_promotors" /id="U2100" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=1274 /SigmaFactorBS="taattcctataagtatactatggattaatGATGGAACAGttc ctataatacCACATATTCTGAAAAGCAGGtactaaaacactttgtgtattttatgcca t" /listShort="S1034, yrzA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2439685..2439749 /Source="Nicolas_S_feature" /locus_tag="new_2788570_2788634" /HighExp="BT, S6, S7, S8, S5, B36, G/S, Pyr, C30, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.975" /TUlongSig="NA" /TUlongPSig="NA" /label="S1034" upshifts 2439685 /Source="Nicolas_upshifts" /id="U2100" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=1274 /SigmaFactorBS="taattcctataagtatactatggattaatGATGGAACAGttc ctataatacCACATATTCTGAAAAGCAGGtactaaaacactttgtgtattttatgcca t" /listShort="S1034, yrzA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2439695..2439698) /Source="Nicolas_upshift_promotors" /id="U2099" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.436563436563437" /psig="0.998001998001998" /xcortree=1746 /SigmaFactorBS="gatggcataaaatacacaaagtgttttaGTACctgcttttca gaataTGTGGTATTATAGGAACTGTtccatcattaatccatagtatacttataggaat t" /listShort="yrrT, mtnN, S1033, mccA, mccB, S1032, yrhC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2439730..2439737 /Source="Nicolas_upshift_promotors" /id="U2101" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.471528471528472" /psig="0.837162837162837" /xcortree=2723 /SigmaFactorBS="gcaggtactaaaacactttgtgtattttatgccatctcaTAT TGCGCattgaccgcaaaaaaGCTTATACTTCATATGACttgtgaaagctggagggtca a" /listShort="yrzA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2439751 /Source="Nicolas_upshifts" /id="U2101" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.471528471528472" /psig="0.837162837162837" /xcortree=2723 /SigmaFactorBS="gcaggtactaaaacactttgtgtattttatgccatctcaTAT TGCGCattgaccgcaaaaaaGCTTATACTTCATATGACttgtgaaagctggagggtca a" /listShort="yrzA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2439753..2439770 /Source="Nicolas_upshift_promotors" /id="U2101" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.471528471528472" /psig="0.837162837162837" /xcortree=2723 /SigmaFactorBS="gcaggtactaaaacactttgtgtattttatgccatctcaTAT TGCGCattgaccgcaaaaaaGCTTATACTTCATATGACttgtgaaagctggagggtca a" /listShort="yrzA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2439795..2439998 /gene="yrzA" /locus_tag="BSU_27290" /old_locus_tag="BSU27290" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390607.1" /db_xref="EnsemblGenomes-Gn:BSU27290" /db_xref="EnsemblGenomes-Tr:CAB14671" /db_xref="InterPro:IPR019686" /db_xref="SubtiList:BG13811" /db_xref="UniProtKB/Swiss-Prot:O32030" /translation="MNFQLDLIKDKVEFFEAASLQELEKKINTQIENNKAIMLRVKSV SHQTLVAEGRILYSAVVHFSAEA*" /label="yrzA CDS" gene 2439795..2439998 /gene="yrzA" /locus_tag="BSU_27290" /old_locus_tag="BSU27290" /label="yrzA gene" downshifts 2440005 /Source="Nicolas_upshifts" /id="D1396" /incds=0 /nref=205 /ntot=257 /MaxReadThrough="1.11529" /MaxDrop="5.39095" /score="26.0850303" /energy="-14.2" /TU="NA" /idTUdmin="U2101" /TUdmin="-10" /isTUend="TRUE" /label="downshifts" CDS complement(2440035..2440736) /gene="yrrS" /locus_tag="BSU_27300" /old_locus_tag="BSU27300" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 14679248" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_390608.1" /db_xref="EnsemblGenomes-Gn:BSU27300" /db_xref="EnsemblGenomes-Tr:CAB14672" /db_xref="GOA:O32031" /db_xref="InterPro:IPR009988" /db_xref="SubtiList:BG13798" /db_xref="UniProtKB/Swiss-Prot:O32031" /translation="MSNNQSRYENRDKRRKANLVLNILIAIVSILIVVVAANLFINSP SSKDVSKDSETAQKQESPASGKTEKKSDEDIKDSKKDTSDSEKDSEKSSDSDSKKDDS SSKKDDSDSDSSSDSAGDGLKDAKVTEGGSSSDVEKTYENPDWKAVGTEQTGEHAATY DSSSQDWAEMLKAISYATGVSTDNMTVLWLGNNGSPQDAKGKILDKATGNKYQVTITW VDEKGWKPTKVEKLK*" /label="yrrS CDS" gene complement(2440035..2440736) /gene="yrrS" /locus_tag="BSU_27300" /old_locus_tag="BSU27300" /label="yrrS gene" downshifts complement(2440047) /Source="Nicolas_upshifts" /id="D1397" /incds=0 /nref=237 /ntot=265 /MaxReadThrough="1.64695" /MaxDrop="6.48551" /score="22.1367505" /energy="-14.2" /TU="NA" /idTUdmin="U2102" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2440801..2442555) /gene="pbpI" /locus_tag="BSU_27310" /old_locus_tag="BSU27310" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:14679248" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14679248; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="penicillin-binding protein PBP4B" /protein_id="NP_390609.1" /db_xref="EnsemblGenomes-Gn:BSU27310" /db_xref="EnsemblGenomes-Tr:CAB14673" /db_xref="GOA:O32032" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR005311" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR036138" /db_xref="SubtiList:BG13797" /db_xref="UniProtKB/Swiss-Prot:O32032" /translation="MKISKRMKLAVIAFLIVFFLLLLRLAEIQLFFTESFSKKKINLI QESVKQRTEEVLISDGRGSFLDRNGRALTGQSEPAVVLFPFLLTQDWPIKKVADILGM SEDDLRQTLGQAKKPVILQQKKIKTLSKQSITKINSLKYPGIYGVYMENEDKPSLASH TIGSTNQDPALLRKKYPDKESLPITTEIGTTGLERTFDEFLLPEQDTKLLYHVDGKGN PLFGMDVKYTAEANTFYPLQIKTTIDQSIQKAMEEVLDEQGLKKGGAVLLDIENSSVL GIVSKPDADVSRQNTLQNYMLTPIYPGSVFKTVIAAAAIENNMVKPSQTFNCNLNLYG EPGDDKGTLSFDESFAQSCNYTFTSLAEQLMKKDSSVIEDMSEKLALTDRAGWEGKLY HETDFRQLYNEKSGVIWGDEKDKSVKKAIAQTAIGQKNVKVTPLEVANMMATIARGGE KRQVKIAEQIEYKNGTTLVTFKDQKLKGETIDKYTSQQLQKILRRVVESPSGTGRRFQ DLPYTVAGKSGTAQTGKLSKEKETLYEKWFAGYFPADKPKYALVVLHMDTPGDKALTN SVFYDIVKKVHEIEINQK*" /label="pbpI CDS" gene complement(2440801..2442555) /gene="pbpI" /locus_tag="BSU_27310" /old_locus_tag="BSU27310" /label="pbpI gene" misc_feature complement(2440829..2440848) /Source="Nicolas_upshift_promotors" /id="U2102" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.938061938061938" /psig="0.998001998001998" /xcortree=2157 /SigmaFactorBS="gttttacacatggatacaccgggagataaggctctgacaaat tcggtgtttTATGATATTGTTAAAAAAGTacacgaaattgaaatcaatcagaaataga a" /listShort="yrrS" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2440839) /Source="Nicolas_upshifts" /id="U2102" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.938061938061938" /psig="0.998001998001998" /xcortree=2157 /SigmaFactorBS="gttttacacatggatacaccgggagataaggctctgacaaat tcggtgtttTATGATATTGTTAAAAAAGTacacgaaattgaaatcaatcagaaataga a" /listShort="yrrS" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2441870..2441885) /Source="Nicolas_upshift_promotors" /id="U2103" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1643 /SigmaFactorBS="agcttttatatcatgtggacggaaaaGGAAACCCTTtgtttg gcatggACGTCAAATATACAGCtgaagccaatacattttatccgctccagatcaaaac a" /listShort="yrrS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2441873) /Source="Nicolas_upshifts" /id="U2103" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1643 /SigmaFactorBS="agcttttatatcatgtggacggaaaaGGAAACCCTTtgtttg gcatggACGTCAAATATACAGCtgaagccaatacattttatccgctccagatcaaaac a" /listShort="yrrS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2441898..2441907) /Source="Nicolas_upshift_promotors" /id="U2103" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1643 /SigmaFactorBS="agcttttatatcatgtggacggaaaaGGAAACCCTTtgtttg gcatggACGTCAAATATACAGCtgaagccaatacattttatccgctccagatcaaaac a" /listShort="yrrS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2442101..2442119) /Source="Nicolas_upshift_promotors" /id="U2104" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.96103896103896" /psig="0.96103896103896" /xcortree=975 /SigmaFactorBS="actttcaaaacaatctatcacaaaaatcaattctttGAAATA tcccggcatttacgGCGTATATATGGAGAATGAagacaagcccagccttgcttcacat a" /listShort="yrrS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2442115) /Source="Nicolas_upshifts" /id="U2104" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.96103896103896" /psig="0.96103896103896" /xcortree=975 /SigmaFactorBS="actttcaaaacaatctatcacaaaaatcaattctttGAAATA tcccggcatttacgGCGTATATATGGAGAATGAagacaagcccagccttgcttcacat a" /listShort="yrrS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2442134..2442141 /Source="Nicolas_upshift_promotors" /id="U2105" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.805194805194805" /psig=1 /xcortree=3003 /SigmaFactorBS="tcattctccatatatacgccgtaaatgccgggaTATTTCAAa gaattgatttttgTGATAGATTGTTTTGAAAGTgttttgattttcttttgctgcaaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(2442134..2442139) /Source="Nicolas_upshift_promotors" /id="U2104" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.96103896103896" /psig="0.96103896103896" /xcortree=975 /SigmaFactorBS="actttcaaaacaatctatcacaaaaatcaattctttGAAATA tcccggcatttacgGCGTATATATGGAGAATGAagacaagcccagccttgcttcacat a" /listShort="yrrS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2442156..2442175 /Source="Nicolas_upshift_promotors" /id="U2105" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.805194805194805" /psig=1 /xcortree=3003 /SigmaFactorBS="tcattctccatatatacgccgtaaatgccgggaTATTTCAAa gaattgatttttgTGATAGATTGTTTTGAAAGTgttttgattttcttttgctgcaaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2442161 /Source="Nicolas_upshifts" /id="U2105" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.805194805194805" /psig=1 /xcortree=3003 /SigmaFactorBS="tcattctccatatatacgccgtaaatgccgggaTATTTCAAa gaattgatttttgTGATAGATTGTTTTGAAAGTgttttgattttcttttgctgcaaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2442609..2443082) /gene="greA" /locus_tag="BSU_27320" /old_locus_tag="BSU27320" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10910724, 16014871, 16707701, 21515770, 28976965" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10910724, 16014871, 16707701, 21515770, 28976965; Product type f: factor" /codon_start=1 /transl_table=11 /product="transcription elongation factor resolving backtracking / stalling" /protein_id="NP_390610.1" /db_xref="EnsemblGenomes-Gn:BSU27320" /db_xref="EnsemblGenomes-Tr:CAB14674" /db_xref="GOA:P80240" /db_xref="InterPro:IPR001437" /db_xref="InterPro:IPR006359" /db_xref="InterPro:IPR018151" /db_xref="InterPro:IPR022691" /db_xref="InterPro:IPR023459" /db_xref="InterPro:IPR028624" /db_xref="InterPro:IPR036805" /db_xref="InterPro:IPR036953" /db_xref="SubtiList:BG19019" /db_xref="UniProtKB/Swiss-Prot:P80240" /translation="MAQEKVFPMTAEGKQKLEQELEYLKTVKRKEVVERIKIARSFGD LSENSEYDSAKEEQAFVEGRVTTLENMIRNAKIIEDDGGSNVVGLGKTVTFVELPDGD EESYTIVGSAEADPFEGKISNDSPIAKSLLGKKVDEEVTVQTPGGEMLVKIVKIS*" /label="greA CDS" gene complement(2442609..2443082) /gene="greA" /locus_tag="BSU_27320" /old_locus_tag="BSU27320" /label="greA gene" downshifts complement(2442616) /Source="Nicolas_upshifts" /id="D1398" /incds=0 /nref=130 /ntot=229 /MaxReadThrough="5.30316" /MaxDrop="4.90519" /score="34.2316821" /energy="-17" /TU="U2107" /idTUdmin="U2106" /TUdmin="-17" /isTUend="TRUE" /label="downshifts" S_feature complement(2443083..2443215) /Source="Nicolas_S_feature" /locus_tag="new_2791968_2792100_c" /HighExp="HPh, C90, dia5, dia15, Diami, H2O2, dia0, Etha, G180, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="0.998, 1, 1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1035" promotor_-10 complement(2443197..2443216) /Source="Nicolas_upshift_promotors" /id="U2106" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.839160839160839" /psig="0.998001998001998" /xcortree=1924 /SigmaFactorBS="gtgcgaattcccttctttccctgtttataaacgcgaaaTATT TGCAgaacgacacgattCAGTTTAAGATAAACAGTACctatatgggagagaagaacga g" /listShort="S1035, greA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2443215) /Source="Nicolas_upshifts" /id="U2106" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.839160839160839" /psig="0.998001998001998" /xcortree=1924 /SigmaFactorBS="gtgcgaattcccttctttccctgtttataaacgcgaaaTATT TGCAgaacgacacgattCAGTTTAAGATAAACAGTACctatatgggagagaagaacga g" /listShort="S1035, greA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2443217..2443325) /Source="Nicolas_S_feature" /locus_tag="new_2792102_2792210_c" /HighExp="HPh, G180, G135, LBGexp, dia0, Paraq, Oxctl, G150, LPh, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1036" promotor_-35 complement(2443230..2443237) /Source="Nicolas_upshift_promotors" /id="U2106" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.839160839160839" /psig="0.998001998001998" /xcortree=1924 /SigmaFactorBS="gtgcgaattcccttctttccctgtttataaacgcgaaaTATT TGCAgaacgacacgattCAGTTTAAGATAAACAGTACctatatgggagagaagaacga g" /listShort="S1035, greA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2443318..2443337) /Source="Nicolas_upshift_promotors" /id="U2107" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.656343656343656" /psig=1 /xcortree=2659 /SigmaFactorBS="atctgatggtcacaaaaattcaaaccatTCTTGaacaaaacg cgatttTGTAATACCATAGCATAGACataaataactctgaccatattatgtataggca g" /listShort="S1036, S1035, greA, pbpI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2443325) /Source="Nicolas_upshifts" /id="U2107" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.656343656343656" /psig=1 /xcortree=2659 /SigmaFactorBS="atctgatggtcacaaaaattcaaaccatTCTTGaacaaaacg cgatttTGTAATACCATAGCATAGACataaataactctgaccatattatgtataggca g" /listShort="S1036, S1035, greA, pbpI" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2443333..2443968) /gene="udk" /locus_tag="BSU_27330" /old_locus_tag="BSU27330" /EC_number="2.7.1.48" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 6208029; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="uridine kinase" /protein_id="NP_390611.1" /db_xref="EnsemblGenomes-Gn:BSU27330" /db_xref="EnsemblGenomes-Tr:CAB14675" /db_xref="GOA:O32033" /db_xref="InterPro:IPR000764" /db_xref="InterPro:IPR006083" /db_xref="InterPro:IPR026008" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12696" /db_xref="UniProtKB/Swiss-Prot:O32033" /translation="MGKNPVVIGIAGGSGSGKTSVTRSIYEQFKGHSILMIQQDLYYK DQSHLPFEERLNTNYDHPLAFDNDYLIEHIQDLLNYRPIEKPIYDYKLHTRSEETVHV EPKDVIILEGILVLEDKRLRDLMDIKLYVDTDADLRIIRRIMRDINERGRSIDSVIEQ YVSVVRPMHNQFVEPTKRYADIIIPEGGQNHVAIDLMVTKIQTILEQNAIL*" /label="udk CDS" gene complement(2443333..2443968) /gene="udk" /locus_tag="BSU_27330" /old_locus_tag="BSU27330" /label="udk gene" promotor_-35 complement(2443353..2443357) /Source="Nicolas_upshift_promotors" /id="U2107" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.656343656343656" /psig=1 /xcortree=2659 /SigmaFactorBS="atctgatggtcacaaaaattcaaaccatTCTTGaacaaaacg cgatttTGTAATACCATAGCATAGACataaataactctgaccatattatgtataggca g" /listShort="S1036, S1035, greA, pbpI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2443463..2443468 /Source="Nicolas_upshift_promotors" /id="U2108" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.865134865134865" /psig="0.865134865134865" /xcortree=1199 /SigmaFactorBS="cgtatcgtttcgtcggctcgacgaattggttaTGCATCggac ggaccactgacACATATTGTTCAATGACAGaatcaatagagcgtccgcgctcattaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2443484..2443502 /Source="Nicolas_upshift_promotors" /id="U2108" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.865134865134865" /psig="0.865134865134865" /xcortree=1199 /SigmaFactorBS="cgtatcgtttcgtcggctcgacgaattggttaTGCATCggac ggaccactgacACATATTGTTCAATGACAGaatcaatagagcgtccgcgctcattaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2443491 /Source="Nicolas_upshifts" /id="U2108" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.865134865134865" /psig="0.865134865134865" /xcortree=1199 /SigmaFactorBS="cgtatcgtttcgtcggctcgacgaattggttaTGCATCggac ggaccactgacACATATTGTTCAATGACAGaatcaatagagcgtccgcgctcattaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2443975..2445243) /gene="yrrO" /locus_tag="BSU_27340" /old_locus_tag="BSU27340" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase large subunit" /protein_id="NP_390612.1" /db_xref="EnsemblGenomes-Gn:BSU27340" /db_xref="EnsemblGenomes-Tr:CAB14676" /db_xref="GOA:O32034" /db_xref="InterPro:IPR001539" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR032525" /db_xref="SubtiList:BG13796" /db_xref="UniProtKB/Swiss-Prot:O32034" /translation="MTAVNDKISTIVNGKRVITKKPELLAPAGNLEKLKIAVHYGADA VFIGGQEYGLRSNADNFTIEEIAEGVEFAKKYGAKIYVTTNIFAHNENMDGLEDYLKA LGDANVAGIIVADPLIIETCRRVAPNVEVHLSTQQSLSNWKAVQFWKEEGLDRVVLAR ETSALEIREMKEKVDIEIESFIHGAMCIAYSGRCVLSNHMTARDSNRGGCCQSCRWDY DLYQTDGANAVALYGEEDAPFAMSPKDLKLIESIPKMIEMGIDSLKIEGRMKSIHYVA TVVSVYRKVIDAYCADPENFVIQKEWLEELDKCANRDTATAFFEGTPGYEEQMFGEHA KKTTYDFVGLVLNYDEDTQMVTLQQRNFFKKGDEVEFFGPEIENFTHTIETIWDEDGN ELDAARHPLQIVKFKLDKKIYPSNMMRKGK*" /label="yrrO CDS" gene complement(2443975..2445243) /gene="yrrO" /locus_tag="BSU_27340" /old_locus_tag="BSU27340" /label="yrrO gene" CDS complement(2445262..2446191) /gene="yrrN" /locus_tag="BSU_27350" /old_locus_tag="BSU27350" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase small subunit" /protein_id="NP_390613.1" /db_xref="EnsemblGenomes-Gn:BSU27350" /db_xref="EnsemblGenomes-Tr:CAB14677" /db_xref="GOA:O32035" /db_xref="InterPro:IPR001539" /db_xref="InterPro:IPR013785" /db_xref="SubtiList:BG13795" /db_xref="UniProtKB/Swiss-Prot:O32035" /translation="MKKPELLVTPTSTADILPLIQAGATAFLVGEQRYGLRLAGEFSR EDVTKAVEIAHKEGAKVYVAVNAIFHNDKVGELGEYLAFLAEAGVDAAVFGDPAVLMA ARESAPDLKLHWSTETTGTNYYTCNYWGRKGAARSVLARELNMDSIVEIKENAEVEIE IQVHGMTCMFQSKRSLIGNYFEYQGKVMDIERKKKESGMFLHDKERDNKYPIFEDENG THIMSPNDVCIIDELEELIDAGIDSFKIDGVLKMPEYLIEVTKMYREAIDLCVENRDE YEAKKEDWIERIESIQPVNRKIDTGFFFKETVY*" /label="yrrN CDS" gene complement(2445262..2446191) /gene="yrrN" /locus_tag="BSU_27350" /old_locus_tag="BSU27350" /label="yrrN gene" CDS complement(2446197..2446850) /gene="yrrM" /locus_tag="BSU_27360" /old_locus_tag="BSU27360" /EC_number="2.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyl-CoA O-methyltransferase" /protein_id="NP_390614.1" /db_xref="EnsemblGenomes-Gn:BSU27360" /db_xref="EnsemblGenomes-Tr:CAB14678" /db_xref="GOA:O32036" /db_xref="InterPro:IPR002935" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG13794" /db_xref="UniProtKB/Swiss-Prot:O32036" /translation="MTDRYEQINDYIEALLKPRPDNVKRLEAYAEEHHVPIMEKAGME VLLQILSVKQPKKILEIGTAIGYSAIRMALELPSAEIYTIERNEKRHEEAVNNIKEFQ LDDRIHVFYGDALELADAVHVTAPYDVIFIDAAKGQYQNFFHLYEPMLSPDGVIITDN VLFKGLVAEDYSKIEPKRRRRLVAKIDEYNHWLMNHPDYQTAIIPVGDGLAISKKKR* " /label="yrrM CDS" gene complement(2446197..2446850) /gene="yrrM" /locus_tag="BSU_27360" /old_locus_tag="BSU27360" /label="yrrM gene" S_feature complement(2446851..2446955) /Source="Nicolas_S_feature" /locus_tag="new_2795736_2795840_c" /HighExp="LBGexp, G180, H2O2, G150, Paraq, Oxctl, G135, dia15, C30, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1037" promotor_-10 complement(2446937..2446956) /Source="Nicolas_upshift_promotors" /id="U2109" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=2599 /SigmaFactorBS="aaaatgagaaataaaaggagagcaaaaagctctccttttGTT CGctttccgcaaggtttTATGATAAAATATATCGGGTtgtttaccgatgtatcatgat g" /listShort="S1037, yrrM, yrrN, yrrO, udk, S1036, S1035, greA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2446955) /Source="Nicolas_upshifts" /id="U2109" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=2599 /SigmaFactorBS="aaaatgagaaataaaaggagagcaaaaagctctccttttGTT CGctttccgcaaggtttTATGATAAAATATATCGGGTtgtttaccgatgtatcatgat g" /listShort="S1037, yrrM, yrrN, yrrO, udk, S1036, S1035, greA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2446972..2446976) /Source="Nicolas_upshift_promotors" /id="U2109" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=2599 /SigmaFactorBS="aaaatgagaaataaaaggagagcaaaaagctctccttttGTT CGctttccgcaaggtttTATGATAAAATATATCGGGTtgtttaccgatgtatcatgat g" /listShort="S1037, yrrM, yrrN, yrrO, udk, S1036, S1035, greA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2447002..2448084) /gene="yrrL" /locus_tag="BSU_27370" /old_locus_tag="BSU27370" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22333191" /codon_start=1 /transl_table=11 /product="conserved membrane associated protein" /protein_id="NP_390615.1" /db_xref="EnsemblGenomes-Gn:BSU27370" /db_xref="EnsemblGenomes-Tr:CAB14679" /db_xref="GOA:O34758" /db_xref="InterPro:IPR003770" /db_xref="SubtiList:BG13793" /db_xref="UniProtKB/Swiss-Prot:O34758" /translation="MYINQQKKSFFNKKRIILSSIVVLFLIIGGAFLYGKSLLEPVEK DSKTTVNINIPSGSSVSAIASILKKNDVIKSEKAFQYYVKYKGASGFQAGFYHLNKGM DLDAIIQKLTSGATGYAFQITVTEGAQLTQIAAAIADETKYSKKQVIAKLDDETFINQ LKKEFPDTVTNDVFNKNIKHPLEGYLFPATYPFNDPDTSLEDIIKAMIKQTNSYVETY KSEMKKNKVSVHKLLTMASLIEEEATEKADRHKIASVFYNRLKKKMPLQTDPTVLYAA GKHKDRVLYKDLEIDSPYNTYKNTGLTPGPIANAGMSSWEAALHPDKTDYLYFLAKSN GEVVFTKTLKEHNKAKEKYISSKNEK*" /label="yrrL CDS" gene complement(2447002..2448084) /gene="yrrL" /locus_tag="BSU_27370" /old_locus_tag="BSU27370" /label="yrrL gene" downshifts complement(2447036) /Source="Nicolas_upshifts" /id="D1399" /incds=0 /nref=21 /ntot=144 /MaxReadThrough="3.5258" /MaxDrop="3.97301" /score="10.5327118" /energy="-11" /TU="U2110" /idTUdmin="U2111" /TUdmin=1173 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2448100..2448119) /Source="Nicolas_upshift_promotors" /id="U2110" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.718281718281718" /psig="0.999000999001" /xcortree=2524 /SigmaFactorBS="ctccggcttttttctgctttatgcaggcctctttttgtaata aATTGccgaaatacaatgaATCATGTAGTATAAGAGCTGatgggaggagacctaatgt a" /listShort="yrrL, S1037, yrrM, yrrN, yrrO, udk, S1036, S1035, greA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2448120) /Source="Nicolas_upshifts" /id="U2110" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.718281718281718" /psig="0.999000999001" /xcortree=2524 /SigmaFactorBS="ctccggcttttttctgctttatgcaggcctctttttgtaata aATTGccgaaatacaatgaATCATGTAGTATAAGAGCTGatgggaggagacctaatgt a" /listShort="yrrL, S1037, yrrM, yrrN, yrrO, udk, S1036, S1035, greA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2448134..2448137) /Source="Nicolas_upshift_promotors" /id="U2110" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.718281718281718" /psig="0.999000999001" /xcortree=2524 /SigmaFactorBS="ctccggcttttttctgctttatgcaggcctctttttgtaata aATTGccgaaatacaatgaATCATGTAGTATAAGAGCTGatgggaggagacctaatgt a" /listShort="yrrL, S1037, yrrM, yrrN, yrrO, udk, S1036, S1035, greA" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2448210) /Source="Nicolas_upshifts" /id="D1400" /incds=0 /nref=260 /ntot=268 /MaxReadThrough="2.55298" /MaxDrop="6.9121" /score="36.0941054" /energy="-15" /TU="NA" /idTUdmin="U2111" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2448215..2448496) /gene="yrzB" /locus_tag="BSU_27380" /old_locus_tag="BSU27380" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22333191; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative nucleic acid binding protein" /protein_id="NP_390616.1" /db_xref="EnsemblGenomes-Gn:BSU27380" /db_xref="EnsemblGenomes-Tr:CAB14680" /db_xref="InterPro:IPR009711" /db_xref="SubtiList:BG13812" /db_xref="UniProtKB/Swiss-Prot:O34828" /translation="MEHGEKNITIVDDQGNEQLCEVLFTFENEEFGKSYVLYYPIESK DDEEVEILASSFTPNEDGENGELFPIETDEEWDMIEETLNTFLADEDEE*" /label="yrzB CDS" gene complement(2448215..2448496) /gene="yrzB" /locus_tag="BSU_27380" /old_locus_tag="BSU27380" /label="yrzB gene" downshifts complement(2448275) /Source="Nicolas_upshifts" /id="D1401" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="6.68915" /MaxDrop="5.19246" /score="36.0941054" /energy="-15" /TU="U2111,U2113,U2114,U2115" /idTUdmin="U2111" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" CDS complement(2448514..2448930) /gene="rimF" /locus_tag="BSU_27390" /old_locus_tag="BSU27390" /function="16.6: Maintain" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15044829, 14512736, 16021622, 22720735, 23251031, 25545592; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="pre-16S ribosomal RNA maturation enzyme" /protein_id="NP_390617.1" /db_xref="EnsemblGenomes-Gn:BSU27390" /db_xref="EnsemblGenomes-Tr:CAB14681" /db_xref="GOA:O34634" /db_xref="InterPro:IPR005227" /db_xref="InterPro:IPR006641" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR037027" /db_xref="PDB:1VHX" /db_xref="SubtiList:BG13792" /db_xref="UniProtKB/Swiss-Prot:O34634" /translation="MRILGLDLGTKTLGVALSDEMGWTAQGIETIKINEAEGDYGLSR LSELIKDYTIDKIVLGFPKNMNGTVGPRGEASQTFAKVLETTYNVPVVLWDERLTTMA AEKMLIAADVSRQKRKKVIDKMAAVMILQGYLDSLN*" /label="rimF CDS" gene complement(2448514..2448930) /gene="rimF" /locus_tag="BSU_27390" /old_locus_tag="BSU27390" /label="rimF gene" promotor_-10 complement(2448762..2448780) /Source="Nicolas_upshift_promotors" /id="U2111" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.54045954045954" /psig="0.54045954045954" /xcortree=676 /SigmaFactorBS="cataaagataaatgaagcagaaggcgattatggtttatccCG TTTAtctgaactgataaagGACTATACTATAGATAAAAtcgtgctcggctttcctaag a" /listShort="yrzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2448781) /Source="Nicolas_upshifts" /id="U2111" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.54045954045954" /psig="0.54045954045954" /xcortree=676 /SigmaFactorBS="cataaagataaatgaagcagaaggcgattatggtttatccCG TTTAtctgaactgataaagGACTATACTATAGATAAAAtcgtgctcggctttcctaag a" /listShort="yrzB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2448796..2448801) /Source="Nicolas_upshift_promotors" /id="U2111" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.54045954045954" /psig="0.54045954045954" /xcortree=676 /SigmaFactorBS="cataaagataaatgaagcagaaggcgattatggtttatccCG TTTAtctgaactgataaagGACTATACTATAGATAAAAtcgtgctcggctttcctaag a" /listShort="yrzB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2448938..2449204) /gene="yrzL" /locus_tag="BSU_27400" /old_locus_tag="BSU27400" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22333191, 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_054589.1" /db_xref="EnsemblGenomes-Gn:BSU27400" /db_xref="EnsemblGenomes-Tr:CAE01464" /db_xref="InterPro:IPR009309" /db_xref="SubtiList:BG14184" /db_xref="UniProtKB/Swiss-Prot:Q7WY61" /translation="MSSFDKTMKFNFSDDSAETNVNEVLITVYDALQEKGYNPINQIV GYLLSGDPAYIPRHRDARNLIRKLERDELIEELVKSYLEQHKEA*" /label="yrzL CDS" gene complement(2448938..2449204) /gene="yrzL" /locus_tag="BSU_27400" /old_locus_tag="BSU27400" /label="yrzL gene" promotor_-35 2449092..2449100 /Source="Nicolas_upshift_promotors" /id="U2112" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1251 /SigmaFactorBS="gcaagtatccgacaatctggttgattggaTTGTAGCCCtttt cctgaagcgcGTCATACACTGTAATCAGCAcctcatttacgttagtctcagcagaatc a" /listShort="S1038" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2449115..2449134 /Source="Nicolas_upshift_promotors" /id="U2112" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1251 /SigmaFactorBS="gcaagtatccgacaatctggttgattggaTTGTAGCCCtttt cctgaagcgcGTCATACACTGTAATCAGCAcctcatttacgttagtctcagcagaatc a" /listShort="S1038" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2449123..2450312 /Source="Nicolas_S_feature" /locus_tag="new_2798008_2799197" /HighExp="S6, C30, C90, S8, S7, Gly, G135, Fru, G180, M/G" /AntisenseName="alaS" /AntisenseCor="-0.27843994691040502" /AntisenseRegPval="-5.5" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S1038" upshifts 2449123 /Source="Nicolas_upshifts" /id="U2112" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1251 /SigmaFactorBS="gcaagtatccgacaatctggttgattggaTTGTAGCCCtttt cctgaagcgcGTCATACACTGTAATCAGCAcctcatttacgttagtctcagcagaatc a" /listShort="S1038" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2449205..2449265) /Source="Nicolas_S_feature" /locus_tag="new_2798090_2798150_c" /HighExp="LBGtran, LBGexp, G135, C90, G150, G180, LBGstat, Oxctl, LoTm, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD, SigA" /TUshortPSig="0.994, 0.997, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1039" promotor_-10 complement(2449259..2449278) /Source="Nicolas_upshift_promotors" /id="U2113" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.57042957042957" /psig="0.994005994005994" /xcortree=3173 /SigmaFactorBS="ggcttctgtagaagattgggtgaaatCCGTTTTAtaattcgc ccatgTAGTGTAGAATGATGGTAAGattaggaccccaggctgaactttgcctgcgaat t" /listShort="S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2449265) /Source="Nicolas_upshifts" /id="U2113" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.57042957042957" /psig="0.994005994005994" /xcortree=3173 /SigmaFactorBS="ggcttctgtagaagattgggtgaaatCCGTTTTAtaattcgc ccatgTAGTGTAGAATGATGGTAAGattaggaccccaggctgaactttgcctgcgaat t" /listShort="S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2449289..2451925) /gene="alaS" /locus_tag="BSU_27410" /old_locus_tag="BSU27410" /EC_number="6.1.1.7" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12554667, 12682299, 17329819, 22720735, 25918376; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alanyl-tRNA synthetase" /protein_id="NP_390618.1" /db_xref="EnsemblGenomes-Gn:BSU27410" /db_xref="EnsemblGenomes-Tr:CAB14682" /db_xref="GOA:O34526" /db_xref="InterPro:IPR002318" /db_xref="InterPro:IPR003156" /db_xref="InterPro:IPR009000" /db_xref="InterPro:IPR012947" /db_xref="InterPro:IPR018162" /db_xref="InterPro:IPR018163" /db_xref="InterPro:IPR018164" /db_xref="InterPro:IPR018165" /db_xref="InterPro:IPR023033" /db_xref="SubtiList:BG12563" /db_xref="UniProtKB/Swiss-Prot:O34526" /translation="MKHLTSAEVRQMFLDFFKEKGHAVEPSASLVPHEDPSLLWINSG VATLKKYFDGRVVPENPRIVNAQKAIRTNDIENVGKTARHHTFFEMLGNFSIGDYFKE EAITWAWEFLTSDKWIGFDKELLSVTVHPEDEEAYEFWAKKIGIPEERIIRLEGNFWD IGEGPSGPNTEIFYDRGEAYGNDPEDPELYPGGENDRYLEVWNLVFSEFNHNPDGTYT PLPKKNIDTGMGLERMVSVIQNVPTNFDTDLFVPIIKATESISGETYGKDNVKDTAFK VIADHIRTVAFAVSDGALPSNEGRGYVLRRLLRRAVRYAKTINIHRPFMFDLVPVVAE IMADFYPEVKEKADFIAKVIKTEEERFHETLNEGLAILSEMIKKEKDKGSSVISGADV FKLYDTYGFPVELTEEYAEDENMTVDHEGFEEEMNQQRERARNARQDVGSMQVQGGAL RDVTVESTFVGYSQTKADANIIVLLQDGQLIEEAHEGESVQIILDETPFYAESGGQIG DKGYLRSEQAVVRIKDVQKAPNGQHVHEGVVESGTVQKGLHVTAEVEDHMRSGVIKNH TATHLLHQALKDVLGTHVNQAGSLVTENRLRFDFSHFGQVTKEELEQIERIVNEKIWA SIPVSIDLKPIAEAKEMGAMALFGEKYGDIVRVVQVGDYSLELCGGCHVRNTAEIGLF KIVSESGIGAGTRRIEAVTGQGAYVEMNSQISVLKQTADELKTNIKEVPKRVAALQAE LKDAQRENESLLAKLGNVEAGAILSKVKEVDGVNVLAAKVNAKDMNHLRTMVDELKAK LGSAVIVLGAVQNDKVNISAGVTKDLIEKGLHAGKLVKQAAEVCGGGGGGRPDMAQAG GKQPEKLEEALASVEDWVKSVL*" /label="alaS CDS" gene complement(2449289..2451925) /gene="alaS" /locus_tag="BSU_27410" /old_locus_tag="BSU27410" /label="alaS gene" promotor_-35 complement(2449292..2449299) /Source="Nicolas_upshift_promotors" /id="U2113" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.57042957042957" /psig="0.994005994005994" /xcortree=3173 /SigmaFactorBS="ggcttctgtagaagattgggtgaaatCCGTTTTAtaattcgc ccatgTAGTGTAGAATGATGGTAAGattaggaccccaggctgaactttgcctgcgaat t" /listShort="S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2451691..2451709) /Source="Nicolas_upshift_promotors" /id="U2114" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1639 /SigmaFactorBS="cggccgtgtcgtgccggaaaatccaagaatcgtaaacGCTCA AAAagcgatcagaacaAACGATATAGAAAATGTAGgtaaaactgcgcgccatcacact t" /listShort="S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2451707) /Source="Nicolas_upshifts" /id="U2114" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1639 /SigmaFactorBS="cggccgtgtcgtgccggaaaatccaagaatcgtaaacGCTCA AAAagcgatcagaacaAACGATATAGAAAATGTAGgtaaaactgcgcgccatcacact t" /listShort="S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2451723..2451730) /Source="Nicolas_upshift_promotors" /id="U2114" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1639 /SigmaFactorBS="cggccgtgtcgtgccggaaaatccaagaatcgtaaacGCTCA AAAagcgatcagaacaAACGATATAGAAAATGTAGgtaaaactgcgcgccatcacact t" /listShort="S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2451926..2452004) /Source="Nicolas_S_feature" /locus_tag="new_2800811_2800889_c" /HighExp="G150, LBGexp, G135, G180, Oxctl, LBGtran, Lbexp, Paraq, dia15, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1040" misc_RNA complement(2452005..2452212) /gene="tboA" /locus_tag="BSU_misc_RNA_40" /product="T-box riboswitch specific of alanine tRNA" /experiment="publication(s) with functional evidences, PMID:1317842, 9098041, 12165569, 12547201" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1317842, 9098041, 12165569, 12547201; Product type n: RNA" /function="16.3: Control" /label="tboA RNA" gene complement(2452005..2452212) /gene="tboA" /locus_tag="BSU_misc_RNA_40" /label="tboA gene" promotor_-10 complement(2452220..2452239) /Source="Nicolas_upshift_promotors" /id="U2115" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.84015984015984" /psig=1 /xcortree=2558 /SigmaFactorBS="aatgatgatccattttttgcggatgaggacggagCATTGACA tcggcgtgccgcttGTCTATAATTTCTCGTAGAAtacatacgaatctcgagtgacgga t" /listShort="NA, S1040, alaS, S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2452235) /Source="Nicolas_upshifts" /id="U2115" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.84015984015984" /psig=1 /xcortree=2558 /SigmaFactorBS="aatgatgatccattttttgcggatgaggacggagCATTGACA tcggcgtgccgcttGTCTATAATTTCTCGTAGAAtacatacgaatctcgagtgacgga t" /listShort="NA, S1040, alaS, S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2452254..2452261) /Source="Nicolas_upshift_promotors" /id="U2115" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.84015984015984" /psig=1 /xcortree=2558 /SigmaFactorBS="aatgatgatccattttttgcggatgaggacggagCATTGACA tcggcgtgccgcttGTCTATAATTTCTCGTAGAAtacatacgaatctcgagtgacgga t" /listShort="NA, S1040, alaS, S1039, yrzL, yrrK, yrzB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2452256..2453317) /gene="yrrI" /locus_tag="BSU_27420" /old_locus_tag="BSU27420" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative membrane protein of unknown function" /protein_id="NP_390619.1" /db_xref="EnsemblGenomes-Gn:BSU27420" /db_xref="EnsemblGenomes-Tr:CAB14683" /db_xref="GOA:O34472" /db_xref="InterPro:IPR002549" /db_xref="SubtiList:BG13791" /db_xref="UniProtKB/Swiss-Prot:O34472" /translation="MLQKPVQLLLWVAICLLVLLTVYVFFMLDMLWSPFWLVIKTIFI PLIISIFISYLLLPVTEWLHGKGLPRTLSILVIYVLFFGGIGWALYKGVPVLIVQLTD LSENIPMFAETYNGLLLHVHNHTDDWPDGMHHRIDKMIRQTEAFFAGTIEGAISGIRN VLDYFLIAATIPFLVFYMVKDIELMKKTVWYLTPKSWRKRGSAFLRDVDDSLGDYIRG QLLVCLILGVIAGISFWVFGLPYPLILGLISGVTNVIPYFGPFIGAVPALLIAMTISV KAVLVVVITVFILQFMEGNILSPFIVGRSLKMHPVVIMLALLAGGELAGIVGMILAVP ATAVLKVMMIHFLRMRTEH*" /label="yrrI CDS" gene complement(2452256..2453317) /gene="yrrI" /locus_tag="BSU_27420" /old_locus_tag="BSU27420" /label="yrrI gene" promotor_-35 2453226..2453231 /Source="Nicolas_upshift_promotors" /id="U2116" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1047 /SigmaFactorBS="atcaagggaataaagatcgtttttatgacgagccaaaagggt gaccatAACATAtcaagcataaaaaagACATAGACTGTTAACAGAAccagcaaacaaa t" /listShort="S1041, glnQ, glnH, glnM, glnP" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2453237..2453472 /Source="Nicolas_S_feature" /locus_tag="new_2802122_2802357" /HighExp="S5, S6, S4, S8, S3, S7, LoTm, BT, M9-stat, T5.0H" /AntisenseName="yrrI" /AntisenseCor="0.71790030040923003" /AntisenseRegPval="-43.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1041" upshifts 2453238 /Source="Nicolas_upshifts" /id="U2116" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1047 /SigmaFactorBS="atcaagggaataaagatcgtttttatgacgagccaaaagggt gaccatAACATAtcaagcataaaaaagACATAGACTGTTAACAGAAccagcaaacaaa t" /listShort="S1041, glnQ, glnH, glnM, glnP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2453247..2453265 /Source="Nicolas_upshift_promotors" /id="U2116" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1047 /SigmaFactorBS="atcaagggaataaagatcgtttttatgacgagccaaaagggt gaccatAACATAtcaagcataaaaaagACATAGACTGTTAACAGAAccagcaaacaaa t" /listShort="S1041, glnQ, glnH, glnM, glnP" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2453334..2453345) /Source="Nicolas_upshift_promotors" /id="U2117" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=801 /SigmaFactorBS="catgacttctgactgactaaagaaacataaAGAATAAttcct tgtaaaccTCAAAAGATATAggtgaggtgaaagcagatgctccaaaaaccggtgcagc t" /listShort="yrrI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2453335) /Source="Nicolas_upshifts" /id="U2117" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=801 /SigmaFactorBS="catgacttctgactgactaaagaaacataaAGAATAAttcct tgtaaaccTCAAAAGATATAggtgaggtgaaagcagatgctccaaaaaccggtgcagc t" /listShort="yrrI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2453359..2453365) /Source="Nicolas_upshift_promotors" /id="U2117" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=801 /SigmaFactorBS="catgacttctgactgactaaagaaacataaAGAATAAttcct tgtaaaccTCAAAAGATATAggtgaggtgaaagcagatgctccaaaaaccggtgcagc t" /listShort="yrrI" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2453473..2454201 /gene="glnQ" /locus_tag="BSU_27430" /old_locus_tag="BSU27430" /EC_number="3.6.3.-" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 1856180; Product type t : transporter" /codon_start=1 /transl_table=11 /product="glutamine ABC transporter (ATP-binding protein)" /protein_id="NP_390620.1" /db_xref="EnsemblGenomes-Gn:BSU27430" /db_xref="EnsemblGenomes-Tr:CAB14684" /db_xref="GOA:O34677" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030679" /db_xref="SubtiList:BG11485" /db_xref="UniProtKB/Swiss-Prot:O34677" /translation="MITFQNVNKHYGDFHVLKQINLQIEKGEVVVIIGPSGSGKSTLL RCINRLESINEGVLTVNGTAINDRKTDINQVRQNIGMVFQHFHLYPHKTVLQNIMLAP VKVLRQSPEQAKETARYYLEKVGIPDKADAYPSQLSGGQQQRVAIARGLAMKPEVMLF DEPTSALDPEMIGEVLDVMKTLAKEGMTMVVVTHEMGFAKEVADRIVFIDEGKILEEA VPAEFYANPKEERARLFLSRILNH*" /label="glnQ CDS" gene 2453473..2454201 /gene="glnQ" /locus_tag="BSU_27430" /old_locus_tag="BSU27430" /label="glnQ gene" downshifts complement(2453929) /Source="Nicolas_upshifts" /id="D1402" /incds=1 /nref=1 /ntot=9 /MaxReadThrough="1.29649" /MaxDrop="3.29152" /score="-3.35464926" /energy="-5.4" /TU="NA" /idTUdmin="U2117" /TUdmin="-726" /isTUend="FALSE" /label="downshifts" CDS 2454223..2455044 /gene="glnH" /locus_tag="BSU_27440" /old_locus_tag="BSU27440" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 1856180; Product type lp : lipoprotein" /codon_start=1 /transl_table=11 /product="glutamine ABC transporter (glutamine-binding lipoprotein)" /protein_id="NP_390621.1" /db_xref="EnsemblGenomes-Gn:BSU27440" /db_xref="EnsemblGenomes-Tr:CAB14685" /db_xref="GOA:O34563" /db_xref="InterPro:IPR001320" /db_xref="InterPro:IPR001638" /db_xref="InterPro:IPR018313" /db_xref="SubtiList:BG11486" /db_xref="UniProtKB/Swiss-Prot:O34563" /translation="MKKIFSLALISLFAVILLAACGSKGSNGEASKESKKDTLAAIKD NDKIVFGVKTDTRLFGLKNPSSGEIEGFDIDIAKQIAKDILGDEKKAQFKEVTSKTRI PMLQNGDIDAIVATMTITEERKKEVDFSDVYFEAGQSLLVKKGSKIKSVENLGKGSKV LAVKGSTSSQNIREKAPEASVLEFENYAEAFTALKSGQGDALTTDNAILYGMADENKN YQLTGKPFTDEPYGIAVKKGQSALAKEINASLKKMKSDGRYDEIYKKWIKEDPAE*" /label="glnH CDS" gene 2454223..2455044 /gene="glnH" /locus_tag="BSU_27440" /old_locus_tag="BSU27440" /label="glnH gene" CDS 2455105..2455755 /gene="glnM" /locus_tag="BSU_27450" /old_locus_tag="BSU27450" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 1856180, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="glutamine ABC transporter (permease)" /protein_id="NP_390622.1" /db_xref="EnsemblGenomes-Gn:BSU27450" /db_xref="EnsemblGenomes-Tr:CAB14686" /db_xref="GOA:O34671" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR010065" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11487" /db_xref="UniProtKB/Swiss-Prot:O34671" /translation="MNVSILFDNFSMYMDGFYHTLLASVIALAGSFVLGVAVAVMRIT VFKPLQWLGTAYVEFIRNIPLLLITFVFYFGLPNAGLRLDGFQAGTVALTIYTSAFIA EAIRAGIQSVSKGQMEAARSSGFTYSQAMLHIILPQAIKIVIPPLGNQFLNLVKNSSI LGVVAGLDLMYQADLVSSSTLVVFDVYIFVALFYLVLTIPLSIGVNYLEKRLEKSY*" /label="glnM CDS" gene 2455105..2455755 /gene="glnM" /locus_tag="BSU_27450" /old_locus_tag="BSU27450" /label="glnM gene" CDS 2455772..2456428 /gene="glnP" /locus_tag="BSU_27460" /old_locus_tag="BSU27460" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 1856180, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="glutamine ABC transporter (permease)" /protein_id="NP_390623.1" /db_xref="EnsemblGenomes-Gn:BSU27460" /db_xref="EnsemblGenomes-Tr:CAB14687" /db_xref="GOA:O34606" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR010065" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11488" /db_xref="UniProtKB/Swiss-Prot:O34606" /translation="MDFIGAYSQEHLAFLWDGFLVTLYVAFISIILSFFFGLIAGTLR YAKVPVLSQLIAVLVETIRNLPLLLIIFFTFFALPEIGIKLEITAAAITALTIFESAM LSEIIRSGLKSIDKGQIEAARSSGLSYTQTLFFIVMPQALRRMVPPIVSQFISLLKDT SLAVVIALPELIHNAQIINGQSADGSYFFPIFLLAALMYFAVNYSLSLAARRLEVRQT *" /label="glnP CDS" gene 2455772..2456428 /gene="glnP" /locus_tag="BSU_27460" /old_locus_tag="BSU27460" /label="glnP gene" downshifts 2456427 /Source="Nicolas_upshifts" /id="D1403" /incds=0 /nref=15 /ntot=32 /MaxReadThrough="2.21558" /MaxDrop="6.08472" /score="5.38937989" /energy="-11.7" /TU="NA" /idTUdmin="U2116" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2456463..2456594) /gene="yrzQ" /locus_tag="BSU_27468" /old_locus_tag="BSU27468" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097766.1" /db_xref="EnsemblGenomes-Gn:BSU27468" /db_xref="EnsemblGenomes-Tr:CAX52672" /db_xref="InterPro:IPR025029" /db_xref="UniProtKB/Swiss-Prot:C0H461" /translation="MNRTMTSLLAMGAGALVYRMATQSDMLNNRSMKRMRRRITKMF* " /label="yrzQ CDS" gene complement(2456463..2456594) /gene="yrzQ" /locus_tag="BSU_27468" /old_locus_tag="BSU27468" /label="yrzQ gene" downshifts complement(2456481) /Source="Nicolas_upshifts" /id="D1404" /incds=0 /nref=50 /ntot=77 /MaxReadThrough="1.58565" /MaxDrop="8.21989" /score="5.69801689" /energy="-11.7" /TU="NA" /idTUdmin="U2118" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2456616..2456807) /gene="yrzR" /locus_tag="BSU_27469" /old_locus_tag="BSU27469" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097767.1" /db_xref="EnsemblGenomes-Gn:BSU27469" /db_xref="EnsemblGenomes-Tr:CAX52673" /db_xref="UniProtKB/Swiss-Prot:C0H462" /translation="MLICPNCKSKDIGKIGVNQYYCWGCFIELTVAKGKIATHQVEED GTLSSLDDLFSEDERSINF*" /label="yrzR CDS" gene complement(2456616..2456807) /gene="yrzR" /locus_tag="BSU_27469" /old_locus_tag="BSU27469" /label="yrzR gene" CDS complement(2456819..2457343) /gene="yrrD" /locus_tag="BSU_27470" /old_locus_tag="BSU27470" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390624.1" /db_xref="EnsemblGenomes-Gn:BSU27470" /db_xref="EnsemblGenomes-Tr:CAB14688" /db_xref="InterPro:IPR011033" /db_xref="InterPro:IPR027275" /db_xref="SubtiList:BG13790" /db_xref="UniProtKB/Swiss-Prot:O34402" /translation="MSLRRKAKPKPVQQKVVDHTLRTCHEVEGFPVYSERTSSYLGTI SDICFSLKGDCLGFILAQKRFLHHHHALLRACDISSIFDDRILASVSSEQLLPLPKSC FTYEQMKMKLVKSQEGDILGMLEDVYFCLDRGIIVAYELSDGFFSDLAGSKRQIQRAD SLVEVRKDEIVLNG*" /label="yrrD CDS" gene complement(2456819..2457343) /gene="yrrD" /locus_tag="BSU_27470" /old_locus_tag="BSU27470" /label="yrrD gene" upshifts complement(2456930) /Source="Nicolas_upshifts" /id="U2118" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.84015984015984" /psig="0.84015984015984" /xcortree=827 /SigmaFactorBS="ggatatattggggatgctggaagaTGTATACttttgtttgga cagGGGCATAATCGTagcatatgaactctcggacggtttcttttctgacctggcggga a" /listShort="yrzR, yrzQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2456934..2456945) /Source="Nicolas_upshift_promotors" /id="U2118" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.84015984015984" /psig="0.84015984015984" /xcortree=827 /SigmaFactorBS="ggatatattggggatgctggaagaTGTATACttttgtttgga cagGGGCATAATCGTagcatatgaactctcggacggtttcttttctgacctggcggga a" /listShort="yrzR, yrzQ" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2456960..2456966) /Source="Nicolas_upshift_promotors" /id="U2118" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.84015984015984" /psig="0.84015984015984" /xcortree=827 /SigmaFactorBS="ggatatattggggatgctggaagaTGTATACttttgtttgga cagGGGCATAATCGTagcatatgaactctcggacggtttcttttctgacctggcggga a" /listShort="yrzR, yrzQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2457314..2457325) /Source="Nicolas_upshift_promotors" /id="U2119" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=838 /SigmaFactorBS="agttttttttcatttgcagtggaattgatttcatCGTATGAg tctaaggcgcaaaGCAAAACCTAAGcctgttcaacaaaaggtggttgatcacactttg a" /listShort="yrrD, yrzR, yrzQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2457320) /Source="Nicolas_upshifts" /id="U2119" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=838 /SigmaFactorBS="agttttttttcatttgcagtggaattgatttcatCGTATGAg tctaaggcgcaaaGCAAAACCTAAGcctgttcaacaaaaggtggttgatcacactttg a" /listShort="yrrD, yrzR, yrzQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2457340..2457346) /Source="Nicolas_upshift_promotors" /id="U2119" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=838 /SigmaFactorBS="agttttttttcatttgcagtggaattgatttcatCGTATGAg tctaaggcgcaaaGCAAAACCTAAGcctgttcaacaaaaggtggttgatcacactttg a" /listShort="yrrD, yrzR, yrzQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2457401..2459797) /gene="recDB" /locus_tag="BSU_27480" /old_locus_tag="BSU27480" /EC_number="3.1.11.5" /function="16.9: Replicate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:3537961, 11557815, 21170359, 22720735, 24443534, 28527403" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3537961, 11557815, 21170359, 22720735, 24443534, 28527403; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="5'-3' helicase associated to SSB; exonuclease V" /protein_id="NP_390625.1" /db_xref="EnsemblGenomes-Gn:BSU27480" /db_xref="EnsemblGenomes-Tr:CAB14689" /db_xref="GOA:O34481" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR006345" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR027785" /db_xref="InterPro:IPR029493" /db_xref="SubtiList:BG13789" /db_xref="UniProtKB/Swiss-Prot:O34481" /translation="MQQHPDQLKLEEEPYLKGTVNTVIYHNDTNLYTVLKVKVTETSE AIEDKAVSVTGYFPALQEEETYTFYGKIVTHPKFGLQFQAEHFKKEIPTTKEGIIQYL SSDLFEGIGKKTAEEIVKKLGDSAINKILADASVLYDVPRLSKKKADTLAGALQRHQG LEQIMISLNQFGFGPQLSMKIYQAYESETLEKIQENPYQLVKDVEGIGFGKADELGSR MGLSGNHPERVKAAILYTLETTCLSEGHTYIETEQLIIDTQSLLNQSAREGQRITEMD AANAIIALGENKDIVIEDGRCYFPSLFYAEQNVAKRVKHIASQTEYENQFPESEFLLA LGELEERMDVQYAPSQKEAIQKALSSPMLLLTGGPGTGKTTVIRGIVELYGELHGVSL DPSAYKKDEAFPIVLAAPTGRAAKRMSESTGLPAVTIHRLLGWNGAEGFTHTEDQPIE GKLLIIDEASMLDIWLANHLFKAIPDHIQIIIVGDEDQLPSVGPGQVLRDLLASQVIP TVRLTDIYRQAEGSSIVELAHQMKNGLLPNNLTAPTKDRSFIRCGGSQIKEVVEKVVA NALKKGYTAKDIQVLAPMYRGKAGINELNVMLQDILNPPKEKRRELKFGDVVYRTGDK ILQLVNQPENNVFNGDIGEITSIFYAKENTEKEDMAVVSFDGNEMTFTKKDFNQFTHA YCCSIHKSQGSEFPIVVLPVVKGYYRMLRRNLLYTAITRAKKFLILCGEEEALEWGVK NNDATVRQTSLKNRLSVQVEEMDAELEALQKELPFSVHDANIGMEGITPFDFMKEEQQ *" /label="recDB CDS" gene complement(2457401..2459797) /gene="recDB" /locus_tag="BSU_27480" /old_locus_tag="BSU27480" /label="recDB gene" downshifts complement(2457427) /Source="Nicolas_upshifts" /id="D1405" /incds=0 /nref=32 /ntot=211 /MaxReadThrough="2.07603" /MaxDrop="3.57113" /score="41.0323102" /energy="-10.8" /TU="NA" /idTUdmin="U2121" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 2457647..2457653 /Source="Nicolas_upshift_promotors" /id="U2120" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=884 /SigmaFactorBS="cctcttccccgcataaaatgagaaatttcttcgctcttgtaa tcgcGGTATAAagaaggtttcttctGAGCATTCTATAatagcctttcacaacaggcaa a" /listShort="S1042" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2457661 /Source="Nicolas_upshifts" /id="U2120" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=884 /SigmaFactorBS="cctcttccccgcataaaatgagaaatttcttcgctcttgtaa tcgcGGTATAAagaaggtttcttctGAGCATTCTATAatagcctttcacaacaggcaa a" /listShort="S1042" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2457668..2457679 /Source="Nicolas_upshift_promotors" /id="U2120" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=884 /SigmaFactorBS="cctcttccccgcataaaatgagaaatttcttcgctcttgtaa tcgcGGTATAAagaaggtttcttctGAGCATTCTATAatagcctttcacaacaggcaa a" /listShort="S1042" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2457681..2458030 /Source="Nicolas_S_feature" /locus_tag="new_2806566_2806915" /HighExp="S8, S5, S6, S7, S4, C30, nit, ferm, G135, T5.0H" /AntisenseName="yrrC" /AntisenseCor="-0.46935785055870999" /AntisenseRegPval="-15.4" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1042" downshifts complement(2457782) /Source="Nicolas_upshifts" /id="D1406" /incds=1 /nref=16 /ntot=163 /MaxReadThrough="4.93428" /MaxDrop="2.86437" /score="41.0323102" /energy="-10.8" /TU="U2121,U2122" /idTUdmin="U2121" /TUdmin="-355" /isTUend="FALSE" /label="downshifts" CDS complement(2459822..2460442) /gene="yrrB" /locus_tag="BSU_27490" /old_locus_tag="BSU27490" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11777911, 12594026, 18180259; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative tetratricopeptide repeat family protein" /protein_id="NP_390626.1" /db_xref="EnsemblGenomes-Gn:BSU27490" /db_xref="EnsemblGenomes-Tr:CAB14690" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR013105" /db_xref="InterPro:IPR019734" /db_xref="PDB:2Q7F" /db_xref="SubtiList:BG13788" /db_xref="UniProtKB/Swiss-Prot:O34452" /translation="MQEGDYEKAAEAFTKAIEENKEDAIPYINFANLLSSVNELERAL AFYDKALELDSSAATAYYGAGNVYVVKEMYKEAKDMFEKALRAGMENGDLFYMLGTVL VKLEQPKLALPYLQRAVELNENDTEARFQFGMCLANEGMLDEALSQFAAVTEQDPGHA DAFYNAGVTYAYKENREKALEMLDKAIDIQPDHMLALHAKKLIDPS*" /label="yrrB CDS" gene complement(2459822..2460442) /gene="yrrB" /locus_tag="BSU_27490" /old_locus_tag="BSU27490" /label="yrrB gene" CDS complement(2460528..2461643) /gene="mnmA" /locus_tag="BSU_27500" /old_locus_tag="BSU27500" /EC_number="2.8.1.13" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12549933, 12756333, 9811540, 15044829, 17580114, 22720735, 25825430" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12549933, 12756333, 9811540, 15044829, 17580114, 22720735, 25825430; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA-specific 2-thiouridylase" /protein_id="NP_390627.3" /db_xref="EnsemblGenomes-Gn:BSU27500" /db_xref="EnsemblGenomes-Tr:CAB14691" /db_xref="GOA:O35020" /db_xref="InterPro:IPR004506" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR023382" /db_xref="SubtiList:BG13787" /db_xref="UniProtKB/Swiss-Prot:O35020" /translation="MEKRPEDTRVVVGMSGGVDSSVAALLLKEQGYDVIGIFMKNWDD TDENGFCTATEDYEDVIRVCNQIGIPYYAVNFEKQYYEKVFQYFLDEYKAGRTPNPDV LCNKEIKFKAFLEHALSLGADYLATGHYARVDRSGGKVRMLRGIDENKDQTYFLNQLT EDTLSKVMFPIGELQKSRVREIAKEAELATATKKDSTGICFIGERNFKTFLSQYLPAQ PGDMMTMDGEVKGRHDGLMYYTIGQRHGLGIGGSGEPWFAVGKDLEKNILYVDQGFHN PLLYSDKITATNISWVRSDIMKGEEISCTAKFRYRQEDHKVTVRMTGEGEAEVIFDEQ VRAVTPGQAVVFYDGEECLGGGTIDDVYKDGTKLWYV*" /label="mnmA CDS" gene complement(2460528..2461643) /gene="mnmA" /locus_tag="BSU_27500" /old_locus_tag="BSU27500" /label="mnmA gene" downshifts complement(2460529) /Source="Nicolas_upshifts" /id="D1407" /incds=0 /nref=2 /ntot=69 /MaxReadThrough="6.45399" /MaxDrop="4.31641" /score="2.49091848" /energy="-7.8" /TU="U2121,U2122" /idTUdmin="U2121" /TUdmin="-3102" /isTUend="FALSE" /label="downshifts" CDS complement(2461674..2462813) /gene="iscSA" /locus_tag="BSU_27510" /old_locus_tag="BSU27510" /EC_number="2.8.1.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7496536, 10930739, 12682299, 17064282, 25825430" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7496536, 10930739, 12682299, 17064282, 25825430; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cysteine desulfurase involved in U34 tRNA thiolation" /protein_id="NP_390629.2" /db_xref="EnsemblGenomes-Gn:BSU27510" /db_xref="EnsemblGenomes-Tr:CAB14693" /db_xref="GOA:O34599" /db_xref="InterPro:IPR000192" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR016454" /db_xref="InterPro:IPR020578" /db_xref="SubtiList:BG13809" /db_xref="UniProtKB/Swiss-Prot:O34599" /translation="MERIYLDHAATSPMDERVLEQMIPHFSGSFGNPSSIHSFGRESR KWVDEARAQIAAEIGAAEQEIIFTSGGTEADNLAIMGTALARKDLGRHIITTKIEHHA VLHTCEKLEGDGFDITYLDVDQNGRVSAKQVKEALRDDTILVTVMYGNNEVGTVQPIE EIGELLKEHKAYFHTDAVQAFGLLPIDVKNSHIDLLSVSGHKLNGPKGTGFLYASKDV KLSPLLFGGEQERKRRAGTENVPGIVGLKEAIKLSSEERDEKNEKYQSFKAIFADTLR DAGVAFEVNGDKEHSLPHVLNLYFPGVSVEALLVNLDMAGVAVSSGSACTAGSVLPSH VLTAMFGEESDRLTSSIRISFGLGNTAEQVKTAAKHVADVVKRLT*" /label="iscSA CDS" gene complement(2461674..2462813) /gene="iscSA" /locus_tag="BSU_27510" /old_locus_tag="BSU27510" /label="iscSA gene" promotor_-10 complement(2462380..2462399) /Source="Nicolas_upshift_promotors" /id="U2121" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.687312687312687" /psig="0.978021978021978" /xcortree=2070 /SigmaFactorBS="acgttgaccaaaatggaagagtcagtgcaaaaCAGGTGAAag aagcactgcgtGATGATACAATCCTTGTGACagtgatgtatggaaataatgaagtcgg a" /listShort="trmU, yrrB, yrrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2462392) /Source="Nicolas_upshifts" /id="U2121" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.687312687312687" /psig="0.978021978021978" /xcortree=2070 /SigmaFactorBS="acgttgaccaaaatggaagagtcagtgcaaaaCAGGTGAAag aagcactgcgtGATGATACAATCCTTGTGACagtgatgtatggaaataatgaagtcgg a" /listShort="trmU, yrrB, yrrC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2462413..2462420) /Source="Nicolas_upshift_promotors" /id="U2121" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.687312687312687" /psig="0.978021978021978" /xcortree=2070 /SigmaFactorBS="acgttgaccaaaatggaagagtcagtgcaaaaCAGGTGAAag aagcactgcgtGATGATACAATCCTTGTGACagtgatgtatggaaataatgaagtcgg a" /listShort="trmU, yrrB, yrrC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2462832..2463248) /gene="cymR" /locus_tag="BSU_27520" /old_locus_tag="BSU27520" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15668000, 16109943, 16513748, 17056751, 18974048, 19508281, 21624051" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15668000, 16109943, 16513748, 17056751, 18974048, 19508281, 21624051; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of cysteine biosynthesis" /protein_id="NP_390630.2" /db_xref="EnsemblGenomes-Gn:BSU27520" /db_xref="EnsemblGenomes-Tr:CAB14694" /db_xref="GOA:O34527" /db_xref="InterPro:IPR000944" /db_xref="InterPro:IPR030489" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2Y75" /db_xref="SubtiList:BG13813" /db_xref="UniProtKB/Swiss-Prot:O34527" /translation="MKISTKGRYGLTIMIELAKKHGEGPTSLKSIAQTNNLSEHYLEQ LVSPLRNAGLVKSIRGAYGGYVLGSEPDAITAGDIIRVLEGPISPVEVLEDEEPAKRE LWIRIRDAVKEVLDSTTLEDLASYTDGEQEAYMFYI*" /label="cymR CDS" gene complement(2462832..2463248) /gene="cymR" /locus_tag="BSU_27520" /old_locus_tag="BSU27520" /label="cymR gene" S_feature complement(2463249..2463346) /Source="Nicolas_S_feature" /locus_tag="new_2812134_2812231_c" /HighExp="Cold, T3.0H, G135, LBGexp, G180, G150, Salt, Lbexp, H2O2, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1043" promotor_-10 complement(2463331..2463350) /Source="Nicolas_upshift_promotors" /id="U2122" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=2578 /SigmaFactorBS="cattagaaaagggtaaaggcccctttccttctgcctcAATGa aaattcgctgaaggTATGTTATAATAACAGTTGGtctataagataataaacggacgaa a" /listShort="S1043, cymR, iscS, trmU, yrrB, yrrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2463346) /Source="Nicolas_upshifts" /id="U2122" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=2578 /SigmaFactorBS="cattagaaaagggtaaaggcccctttccttctgcctcAATGa aaattcgctgaaggTATGTTATAATAACAGTTGGtctataagataataaacggacgaa a" /listShort="S1043, cymR, iscS, trmU, yrrB, yrrC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2463366..2463369) /Source="Nicolas_upshift_promotors" /id="U2122" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=2578 /SigmaFactorBS="cattagaaaagggtaaaggcccctttccttctgcctcAATGa aaattcgctgaaggTATGTTATAATAACAGTTGGtctataagataataaacggacgaa a" /listShort="S1043, cymR, iscS, trmU, yrrB, yrrC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2463394..2463401 /Source="Nicolas_upshift_promotors" /id="U2123" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=1971 /SigmaFactorBS="tttcattgaggcagaaggaaaggggcctttaCCCTTTTCtaa tgtacggtttTCCGTTACCCTGTAATTAAGtaaggagagatgatagatgaagccattg g" /listShort="yrvN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2463415..2463434 /Source="Nicolas_upshift_promotors" /id="U2123" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=1971 /SigmaFactorBS="tttcattgaggcagaaggaaaggggcctttaCCCTTTTCtaa tgtacggtttTCCGTTACCCTGTAATTAAGtaaggagagatgatagatgaagccattg g" /listShort="yrvN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2463423 /Source="Nicolas_upshifts" /id="U2123" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=1971 /SigmaFactorBS="tttcattgaggcagaaggaaaggggcctttaCCCTTTTCtaa tgtacggtttTCCGTTACCCTGTAATTAAGtaaggagagatgatagatgaagccattg g" /listShort="yrvN" /GFF_Attribute="listLong" /label="upshifts" CDS 2463451..2464716 /gene="rarA" /locus_tag="BSU_27530" /old_locus_tag="BSU27530" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15743409, 17641684, 21170359" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15743409, 17641684, 21170359; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA-dependent ATPase active at replication forks" /protein_id="NP_390631.1" /db_xref="EnsemblGenomes-Gn:BSU27530" /db_xref="EnsemblGenomes-Tr:CAB14695" /db_xref="GOA:O34528" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR008824" /db_xref="InterPro:IPR008921" /db_xref="InterPro:IPR021886" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR032423" /db_xref="SubtiList:BG13808" /db_xref="UniProtKB/Swiss-Prot:O34528" /translation="MKPLAYRMRPTKIEDIIGQQHLVAEDKIIGRMVQAKHLSSMILY GPPGIGKTSIATAIAGSTSIAFRKLNAVINNKKDMEIVAQEAKMSGQVILILDEVHRL DKGKQDFLLPYLENGMIILIGATTANPYHAINPAIRSRTQIFELEPLTPELIKQALER ALHDEHRGLGTYSVSIDDQAMEHFAHGCGGDVRSALNALELAVLSTKESADGEIHITL ETAEECLQKKSFSHDKDGDAHYDVLSAFQKSIRGSDANAALHYLARLIEAGDLESIAR RLLVIAYEDIGLASPQAGPRVLNAIQTAERVGFPEARIPLANAVIELCLSPKSNSAIL AIDEALADIRAGKIGDVPKHLKDAHYKGAQELGRGIDYKYPHNYDNGWVEQQYLPDPL KNKQYYKPKQTGKFESALKQVYDKLMKRK*" /label="rarA CDS" gene 2463451..2464716 /gene="rarA" /locus_tag="BSU_27530" /old_locus_tag="BSU27530" /label="rarA gene" downshifts 2464715 /Source="Nicolas_upshifts" /id="D1408" /incds=0 /nref=24 /ntot=228 /MaxReadThrough="1.09429" /MaxDrop="4.5261" /score="14.6665846" /energy="-12" /TU="NA" /idTUdmin="U2123" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" CDS complement(2464758..2465522) /gene="tcdA" /locus_tag="BSU_27540" /old_locus_tag="BSU27540" /EC_number="6.1.-.-" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12177353, 20097860, 23242255, 27913733, 28671653; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA threonylcarbamoyladenosine dehydratase (t(6)A37 dehydratase)" /protein_id="NP_390632.3" /db_xref="EnsemblGenomes-Gn:BSU27540" /db_xref="EnsemblGenomes-Tr:CAB14713" /db_xref="GOA:O32037" /db_xref="InterPro:IPR000594" /db_xref="InterPro:IPR035985" /db_xref="SubtiList:BG13807" /db_xref="UniProtKB/Swiss-Prot:O32037" /translation="MLHQFSRNELAIGKEGLETLKNSTVAVLGVGGVGSFAAEALARS GVGRILLVDKDDVDITNVNRQLHALLSTVGQPKVDLMKARIADINPECEVIALKMFYT EETYEQFFDYGLDYVIDASDTICYKIHLMKECLKRDIPLISSMGAANKTDPTRFQIAD ISKTHTDPIAKVVRTKLRKEGIKKGVQVIFSDESPIVIREDVRKEVGNDEAKIRKAKM PPSSNAFVPSVAGLIMGGHVVMDLLKDIEIKRVKDK*" /label="tcdA CDS" gene complement(2464758..2465522) /gene="tcdA" /locus_tag="BSU_27540" /old_locus_tag="BSU27540" /label="tcdA gene" downshifts complement(2464776) /Source="Nicolas_upshifts" /id="D1409" /incds=0 /nref=246 /ntot=264 /MaxReadThrough="2.35294" /MaxDrop="7.20309" /score="44.7253801" /energy="-12" /TU="NA" /idTUdmin="U2125" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_RNA complement(2465606..2465806) /gene="ssrSB" /locus_tag="BSU_misc_RNA_41" /product="6Sb RNA" /experiment="publication(s) with functional evidences, PMID:12177353, 15793584, 15811922, 25576829, 26873600" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12177353, 15793584, 15811922, 25576829, 26873600; Product type n: RNA" /label="ssrSB RNA" gene complement(2465606..2465806) /gene="ssrSB" /locus_tag="BSU_misc_RNA_41" /label="ssrSB gene" downshifts complement(2465624) /Source="Nicolas_upshifts" /id="D1410" /incds=0 /nref=81 /ntot=303 /MaxReadThrough="7.44881" /MaxDrop="6.73892" /score="44.7253801" /energy="-12" /TU="U2125,U2127" /idTUdmin="U2125" /TUdmin="-848" /isTUend="FALSE" /label="downshifts" upshifts 2465793 /Source="Nicolas_upshifts" /id="U2124" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.425574425574426" /psig="0.143856143856144" /xcortree=714 /SigmaFactorBS="gcgggctcccaaatcaaaaaaatgttcggtcaaaactaggtg tacaactaacacatcaggaCTTTATTTAActtgtcaaaatcatatcacagacgatttt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 2465794..2465803 /Source="Nicolas_upshift_promotors" /id="U2124" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.425574425574426" /psig="0.143856143856144" /xcortree=714 /SigmaFactorBS="gcgggctcccaaatcaaaaaaatgttcggtcaaaactaggtg tacaactaacacatcaggaCTTTATTTAActtgtcaaaatcatatcacagacgatttt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(2465804..2465823) /Source="Nicolas_upshift_promotors" /id="U2125" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.578421578421578" /psig=1 /xcortree=392 /SigmaFactorBS="aaaaaagttaagaactgaatttgcagttcgatTCTTGAAAat caaaatcgtcTGTGATATGATTTTGACAAGttaaataaagtcctgatgtgttagttgt a" /listShort="NA, yrvM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2465815) /Source="Nicolas_upshifts" /id="U2125" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.578421578421578" /psig=1 /xcortree=392 /SigmaFactorBS="aaaaaagttaagaactgaatttgcagttcgatTCTTGAAAat caaaatcgtcTGTGATATGATTTTGACAAGttaaataaagtcctgatgtgttagttgt a" /listShort="NA, yrvM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2465836..2465843) /Source="Nicolas_upshift_promotors" /id="U2125" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.578421578421578" /psig=1 /xcortree=392 /SigmaFactorBS="aaaaaagttaagaactgaatttgcagttcgatTCTTGAAAat caaaatcgtcTGTGATATGATTTTGACAAGttaaataaagtcctgatgtgttagttgt a" /listShort="NA, yrvM" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2465858..2467636) /gene="aspS" /locus_tag="BSU_27550" /old_locus_tag="BSU27550" /EC_number="6.1.1.12" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12177353, 26804570" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12177353, 26804570; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aspartyl-tRNA synthetase, promiscuous (also recognizes tRNAasn)" /protein_id="NP_390633.1" /db_xref="EnsemblGenomes-Gn:BSU27550" /db_xref="EnsemblGenomes-Tr:CAB14714" /db_xref="GOA:O32038" /db_xref="InterPro:IPR002312" /db_xref="InterPro:IPR004115" /db_xref="InterPro:IPR004364" /db_xref="InterPro:IPR004365" /db_xref="InterPro:IPR004524" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR029351" /db_xref="SubtiList:BG12572" /db_xref="UniProtKB/Swiss-Prot:O32038" /translation="MFGRTYYCGDITEKAIGESVTLKGWVQKRRDLGGLIFIDLRDRT GIVQVVFNPDVSKEALAIAEGIRNEYVLDIQGKVVAREEGTVNPNLKTGAIEIHADGV NVLNAAKTPPFAISDQAEEVSEDVRLKHRYLDLRRPAMFQTMQLRHNVTKAVRSFLDE NGFLDIETPILTGSTPEGARDYLVPSRVHEGEFYALPQSPQLFKQLLMVSGIERYYQI ARCFRDEDLRADRQPEFTQIDIEMSFMSQEDIMSLAEEMMAKVMRETKGEELQLPLPR MTYDEAMNKYGSDKPDTRFDMLLTDVSDIVKDTEFKVFSSAVANGGVVKAINVKGGAG DYSRKDIDALGAFAANYGAKGLAWVKVEADGVKGPIAKFFDEEKQSKLIEALDAAEGD LLLFGADQFEVVAASLGALRLKLGKERGLIDEKLFNFLWVIDWPLLEHDPEEGRFYAA HHPFTMPVREDLELIETAPEDMKAQAYDLVLNGYELGGGSIRIFEKDIQEKMFALLGF SPEEAAEQFGFLLEAFEYGAPPHGGIALGLDRLVMLLAGRTNLRDTIAFPKTASASCL MTEAPGEVSDAQLDELHLSIKKKVKN*" /label="aspS CDS" gene complement(2465858..2467636) /gene="aspS" /locus_tag="BSU_27550" /old_locus_tag="BSU27550" /label="aspS gene" CDS complement(2467650..2468924) /gene="hisS" /locus_tag="BSU_27560" /old_locus_tag="BSU27560" /EC_number="6.1.1.21" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 28321488; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="histidyl-tRNA synthetase" /protein_id="NP_390634.1" /db_xref="EnsemblGenomes-Gn:BSU27560" /db_xref="EnsemblGenomes-Tr:CAB14715" /db_xref="GOA:O32039" /db_xref="InterPro:IPR004154" /db_xref="InterPro:IPR004516" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR015807" /db_xref="InterPro:IPR033656" /db_xref="InterPro:IPR036621" /db_xref="SubtiList:BG12605" /db_xref="UniProtKB/Swiss-Prot:O32039" /translation="MGYNIPRGTQDILPGESDRWQFVEQIMRDTCRTYQYKEIRTPIF EHTELFARGVGESTDIVQKEMYTFEDRKGRSLTLRPEGTAAAVRAFNENKLFANPVQP TKLYYVGPMFRYERPQTGRYRQFYQFGIEAIGSKDPAIDAEVMALAMSIYEKAGLENV KLVINSLGDQDSRKSYREALVKHFEPRIEEFCSDCQSRLHTNPLRILDCKKDRDHELM KSAPSILTYLNEESAAYFEKVKQYLNDLGISYEIDPNLVRGLDYYNHTAFEIMSNAEG FGAITTLAGGGRYDGLVEQIGGPEAPGIGFAMSIERLLAAIDAEKRELPVDKGIDCYI VTLGEKAKDYSVSLVYKLREAGISSEIDYENKKMKGQFKTADRLKARFIAILGEDELA QNKINVKDAQTGEQIEVALDEFIHVMKANQKG*" /label="hisS CDS" gene complement(2467650..2468924) /gene="hisS" /locus_tag="BSU_27560" /old_locus_tag="BSU27560" /label="hisS gene" misc_RNA complement(2469014..2469246) /gene="tboH" /locus_tag="BSU_misc_RNA_42" /product="T-box riboswitch controlling synthesis of histidine and aspartate tRNA ligases" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.3: Control" /label="tboH RNA" gene complement(2469014..2469246) /gene="tboH" /locus_tag="BSU_misc_RNA_42" /label="tboH gene" downshifts complement(2469044) /Source="Nicolas_upshifts" /id="D1411" /incds=0 /nref=71 /ntot=180 /MaxReadThrough="7.0761" /MaxDrop="5.61082" /score="40.6097692" /energy="-23.7" /TU="U2127" /idTUdmin="U2128" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 2469256..2469259 /Source="Nicolas_upshift_promotors" /id="U2126" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.582417582417582" /psig=1 /xcortree=2538 /SigmaFactorBS="ctgacctactcttctccattattggttcaaatctttcatcAT TTgctatgtactcaatTTCTATTATAATAATGGGATtggggttctctgtcaagcttta t" /listShort="S1044, yrvJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2469270..2469289) /Source="Nicolas_upshift_promotors" /id="U2127" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.9000999000999" /psig=1 /xcortree=3008 /SigmaFactorBS="ccaaagaagcagcgctgaggaaaaacaaccggaataaaGCTT GACAgagaaccccaatccCATTATTATAATAGAAATTGagtacatagcaaatgatgaa a" /listShort="NA, hisS, aspS, NA, yrvM" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 2469274..2469293 /Source="Nicolas_upshift_promotors" /id="U2126" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.582417582417582" /psig=1 /xcortree=2538 /SigmaFactorBS="ctgacctactcttctccattattggttcaaatctttcatcAT TTgctatgtactcaatTTCTATTATAATAATGGGATtggggttctctgtcaagcttta t" /listShort="S1044, yrvJ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2469276..2469560 /Source="Nicolas_S_feature" /locus_tag="new_2818161_2818445" /HighExp="H2O2, G135, G180, C30, G150, Paraq, Oxctl, dia15, LBGstat, LBGexp" /AntisenseName="yrzK" /AntisenseCor="-0.27832941694878799" /AntisenseRegPval="-5.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1044" upshifts 2469276 /Source="Nicolas_upshifts" /id="U2126" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.582417582417582" /psig=1 /xcortree=2538 /SigmaFactorBS="ctgacctactcttctccattattggttcaaatctttcatcAT TTgctatgtactcaatTTCTATTATAATAATGGGATtggggttctctgtcaagcttta t" /listShort="S1044, yrvJ" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2469289) /Source="Nicolas_upshifts" /id="U2127" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.9000999000999" /psig=1 /xcortree=3008 /SigmaFactorBS="ccaaagaagcagcgctgaggaaaaacaaccggaataaaGCTT GACAgagaaccccaatccCATTATTATAATAGAAATTGagtacatagcaaatgatgaa a" /listShort="NA, hisS, aspS, NA, yrvM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2469304..2469311) /Source="Nicolas_upshift_promotors" /id="U2127" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.9000999000999" /psig=1 /xcortree=3008 /SigmaFactorBS="ccaaagaagcagcgctgaggaaaaacaaccggaataaaGCTT GACAgagaaccccaatccCATTATTATAATAGAAATTGagtacatagcaaatgatgaa a" /listShort="NA, hisS, aspS, NA, yrvM" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2469306..2469476) /gene="yrzK" /locus_tag="BSU_27570" /old_locus_tag="BSU27570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390635.1" /db_xref="EnsemblGenomes-Gn:BSU27570" /db_xref="EnsemblGenomes-Tr:CAB14716" /db_xref="InterPro:IPR035378" /db_xref="SubtiList:BG13820" /db_xref="UniProtKB/Swiss-Prot:O32040" /translation="MKYHPKMGRAFHDGEANLHYSDHADPDTTGYLTETASEFGLMSK EAALRKNNRNKA*" /label="yrzK CDS" gene complement(2469306..2469476) /gene="yrzK" /locus_tag="BSU_27570" /old_locus_tag="BSU27570" /label="yrzK gene" promotor_-10 complement(2469507..2469518) /Source="Nicolas_upshift_promotors" /id="U2128" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.945054945054945" /psig="0.945054945054945" /xcortree=906 /SigmaFactorBS="taaaaaagcattcttgtttaatatcgtaaagtcctttctgat tttTAAATAAaaataaaatgatttGTTTATACTAAGcgtaaatacaatcaaaaaggtg t" /listShort="yrzK, NA" /listLong="hisS, aspS, NA, yrvM" /label="promotor_-10" upshifts complement(2469524) /Source="Nicolas_upshifts" /id="U2128" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.945054945054945" /psig="0.945054945054945" /xcortree=906 /SigmaFactorBS="taaaaaagcattcttgtttaatatcgtaaagtcctttctgat tttTAAATAAaaataaaatgatttGTTTATACTAAGcgtaaatacaatcaaaaaggtg t" /listShort="yrzK, NA" /listLong="hisS, aspS, NA, yrvM" /label="upshifts" promotor_-35 complement(2469533..2469539) /Source="Nicolas_upshift_promotors" /id="U2128" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.945054945054945" /psig="0.945054945054945" /xcortree=906 /SigmaFactorBS="taaaaaagcattcttgtttaatatcgtaaagtcctttctgat tttTAAATAAaaataaaatgatttGTTTATACTAAGcgtaaatacaatcaaaaaggtg t" /listShort="yrzK, NA" /listLong="hisS, aspS, NA, yrvM" /label="promotor_-35" promotor_-35 2469536..2469543 /Source="Nicolas_upshift_promotors" /id="U2129" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2794 /SigmaFactorBS="ttacgcttagtataaacaaatcattttatttttaTTTAAAAA tcagaaaggacttTACGATATTAAACAAGAATgcttttttaatgatcatcagaaagga g" /listShort="yrvJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2469557..2469575 /Source="Nicolas_upshift_promotors" /id="U2129" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2794 /SigmaFactorBS="ttacgcttagtataaacaaatcattttatttttaTTTAAAAA tcagaaaggacttTACGATATTAAACAAGAATgcttttttaatgatcatcagaaagga g" /listShort="yrvJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2469562 /Source="Nicolas_upshifts" /id="U2129" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2794 /SigmaFactorBS="ttacgcttagtataaacaaatcattttatttttaTTTAAAAA tcagaaaggacttTACGATATTAAACAAGAATgcttttttaatgatcatcagaaagga g" /listShort="yrvJ" /GFF_Attribute="listLong" /label="upshifts" CDS 2469609..2471165 /gene="yrvJ" /locus_tag="BSU_27580" /old_locus_tag="BSU27580" /EC_number="3.5.1.28" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetylmuramoyl-L-alanine amidase, family 3" /protein_id="NP_390636.1" /db_xref="EnsemblGenomes-Gn:BSU27580" /db_xref="EnsemblGenomes-Tr:CAB14717" /db_xref="GOA:O32041" /db_xref="InterPro:IPR002508" /db_xref="InterPro:IPR003646" /db_xref="InterPro:IPR017293" /db_xref="SubtiList:BG13806" /db_xref="UniProtKB/Swiss-Prot:O32041" /translation="MNKKYFVLIVCIIFTSALFPTFSSVTAAQGEAVIATDEMNVRSG PGLSYGITAEVKKGERYPILKEDGDWVQIQLGSGEKGWVVSWLITKEDQASTSSSGSS DTVTSTDPDLRMRSGPGTSYEVIGKFPQGSQASVIDKDSGWIKISYHSATGWVSSEYV TSGGSSSASDESDQTEDSGASTTGTVGVSSLNVRASASHDAAIITKLDRGTKLTVLNE KNGWAHIEVNGLKGWVASHYLLTSSVPADDSANAGSSSSAKKAYIMYGGTNLRSDAST SASIVERAAKGDSYTITGSKGSWYEIKLDNGQTAYVANWVVQTSKSAEEAGEPPVSDS PSGNGSLNNKTIIVDPGHGGKDSGTIGYSGKFEKNLTIKTAKLLASKLRSAGADVYVT RQDDTFVSLQSRVSTSHYRNADAFISIHYDSYADTSTRGSTAYYYSPAKDQELASDVH SEVVKRSSIPDRGVLFGDYYVLRENRQPAMLYELGYVSHPQEEAIVHSNSYQEKVTDG IESGLEKYFQ*" /label="yrvJ CDS" gene 2469609..2471165 /gene="yrvJ" /locus_tag="BSU_27580" /old_locus_tag="BSU27580" /label="yrvJ gene" downshifts 2471144 /Source="Nicolas_upshifts" /id="D1412" /incds=0 /nref=199 /ntot=249 /MaxReadThrough="2.10072" /MaxDrop="7.40599" /score="44.9570925" /energy="-9.9" /TU="U2126" /idTUdmin="U2129" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(2471192..2471590) /gene="dtd" /locus_tag="BSU_27590" /old_locus_tag="BSU27590" /EC_number="3.1.-.-" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15292242, 15525705, 16844682, 18700836, 28362257; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="gly-tRNA(Ala) deacylase / D-Tyr-tRNATyr deacylase" /protein_id="NP_390637.2" /db_xref="EnsemblGenomes-Gn:BSU27590" /db_xref="EnsemblGenomes-Tr:CAB14718" /db_xref="GOA:O32042" /db_xref="InterPro:IPR003732" /db_xref="InterPro:IPR023509" /db_xref="SubtiList:BG13805" /db_xref="UniProtKB/Swiss-Prot:O32042" /translation="MDEEVVGQIGQGLMVLVGITHDDTEDDAAYLADKVVNLRIFDDS EGKMNLSLVDIGGEILSVSQFTLYGDTKKGRRPNYMNAAKPDKALGLYEKWNDLLREK GIKVETGTFGAMMDVQLTNSGPVTLIMDSK*" /label="dtd CDS" gene complement(2471192..2471590) /gene="dtd" /locus_tag="BSU_27590" /old_locus_tag="BSU27590" /label="dtd gene" downshifts complement(2471200) /Source="Nicolas_upshifts" /id="D1413" /incds=0 /nref=152 /ntot=267 /MaxReadThrough="2.01735" /MaxDrop="9.47739" /score="37.3693259" /energy="-9.9" /TU="NA" /idTUdmin="U2130" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2471644..2473848) /gene="rsh" /locus_tag="BSU_27600" /old_locus_tag="BSU27600" /EC_number="2.7.6.5" /EC_number="3.1.7.2" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:6248722, 9383190, 11545276, 12081964, 12372825, 13129942, 15066282, 17183219, 18067544, 18996989, 26460002" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6248722, 9383190, 11545276, 12081964, 12372825, 13129942, 15066282, 17183219, 18067544, 18996989, 26460002; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="GTP pyrophosphokinase (RelA/SpoT)" /protein_id="NP_390638.2" /db_xref="EnsemblGenomes-Gn:BSU27600" /db_xref="EnsemblGenomes-Tr:CAB14719" /db_xref="GOA:O54408" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR004095" /db_xref="InterPro:IPR004811" /db_xref="InterPro:IPR007685" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR012676" /db_xref="InterPro:IPR033655" /db_xref="SubtiList:BG12665" /db_xref="UniProtKB/Swiss-Prot:O54408" /translation="MANEQVLTAEQVIDKARSYLSDEHIAFVEKAYLYAEDAHREQYR KSGEPYIIHPIQVAGILVDLEMDPSTIAGGFLHDVVEDTDVTLDDLKEAFSEEVAMLV DGVTKLGKIKYKSQEEQQAENHRKMFVAMAQDIRVILIKLADRLHNMRTLKHLPQEKQ RRISNETLEIFAPLAHRLGISKIKWELEDTALRYLNPQQYYRIVNLMKKKRAERELYV DEVVNEVKKRVEEVNIKADFSGRPKHIYSIYRKMVLQNKQFNEIYDLLAVRILVNSIK DCYAVLGIIHTCWKPMPGRFKDYIAMPKPNMYQSLHTTVIGPKGDPLEVQIRTFEMHE IAEYGVAAHWAYKEGKAANEGATFEKKLSWFREILEFQNESTDAEEFMESLKIDLFSD MVYVFTPKGDVIELPSGSVPIDFSYRIHSEIGNKTIGAKVNGKMVTLDHKLRTGDIVE ILTSKHSYGPSQDWVKLAQTSQAKHKIRQFFKKQRREENVEKGRELVEKEIKNLDFEL KDVLTPENIQKVADKFNFSNEEDMYAAVGYNGITALQVANRLTEKERKQRDQEEQEKI VQEVTGEPKPYPQGRKREAGVRVKGIDNLLVRLSKCCNPVPGDDIVGFITKGRGVSVH REDCPNVKTNEAQERLIPVEWEHESQVQKRKEYNVEIEILGYDRRGLLNEVLQAVNET KTNISSVSGKSDRNKVATIHMAIFIQNINHLHKVVERIKQIRDIYSVRRVMN*" /label="rsh CDS" gene complement(2471644..2473848) /gene="rsh" /locus_tag="BSU_27600" /old_locus_tag="BSU27600" /label="rsh gene" promotor_-10 complement(2473877..2473896) /Source="Nicolas_upshift_promotors" /id="U2130" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.648351648351648" /psig="0.998001998001998" /xcortree=2252 /SigmaFactorBS="taatatttggctatttgaacttctgcTCTTTACAtctttcgt ttttttCTTGATAATAAACTACAATAcagtttacattttaaaaaaggtgattccatgg c" /listShort="relA, dtd" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2473884) /Source="Nicolas_upshifts" /id="U2130" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.648351648351648" /psig="0.998001998001998" /xcortree=2252 /SigmaFactorBS="taatatttggctatttgaacttctgcTCTTTACAtctttcgt ttttttCTTGATAATAAACTACAATAcagtttacattttaaaaaaggtgattccatgg c" /listShort="relA, dtd" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2473886..2473976) /Source="Nicolas_S_feature" /locus_tag="new_2822771_2822861_c" /HighExp="Cold, G135, G180, G150, H2O2, Paraq, Oxctl, C30, LBGexp, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA, SigB" /TUshortPSig="0.951, 1, 1" /TUlongSig="SigA, SigA" /TUlongPSig="0.999, 1" /label="S1045" promotor_-35 complement(2473911..2473918) /Source="Nicolas_upshift_promotors" /id="U2130" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.648351648351648" /psig="0.998001998001998" /xcortree=2252 /SigmaFactorBS="taatatttggctatttgaacttctgcTCTTTACAtctttcgt ttttttCTTGATAATAAACTACAATAcagtttacattttaaaaaaggtgattccatgg c" /listShort="relA, dtd" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2473940 /Source="Nicolas_upshifts" /id="D1414" /incds=0 /nref=1 /ntot=14 /MaxReadThrough="1.75679" /MaxDrop="3.54336" /score="0.486890657" /energy="-12.7" /TU="NA" /idTUdmin="U2126" /TUdmin=2772 /isTUend="FALSE" /label="downshifts" CDS complement(2474016..2474528) /gene="apt" /locus_tag="BSU_27610" /old_locus_tag="BSU27610" /EC_number="2.4.2.7" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:6408059, 9383190, 15629952" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6408059, 9383190, 15629952; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="adenine phosphoribosyltransferase" /protein_id="NP_390639.1" /db_xref="EnsemblGenomes-Gn:BSU27610" /db_xref="EnsemblGenomes-Tr:CAB14720" /db_xref="GOA:O34443" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR005764" /db_xref="InterPro:IPR029057" /db_xref="SubtiList:BG12568" /db_xref="UniProtKB/Swiss-Prot:O34443" /translation="MDLKQYVTIVPDYPKEGVQFKDITTLMDKGDVYRYATDQIVEYA KEKQIDLVVGPEARGFIIGCPVAYALGVGFAPVRKEGKLPREVIKVDYGLEYGKDVLT IHKDAIKPGQRVLITDDLLATGGTIEATIKLVEELGGVVAGIAFLIELSYLDGRNKLE DYDILTLMKY*" /label="apt CDS" gene complement(2474016..2474528) /gene="apt" /locus_tag="BSU_27610" /old_locus_tag="BSU27610" /label="apt gene" downshifts complement(2474021) /Source="Nicolas_upshifts" /id="D1415" /incds=0 /nref=39 /ntot=228 /MaxReadThrough="5.36411" /MaxDrop="4.05036" /score="2.83935873" /energy="-6.8" /TU="U2131,U2132,U2133" /idTUdmin="U2131" /TUdmin="-115" /isTUend="FALSE" /label="downshifts" CDS complement(2474534..2476894) /gene="recJ" /locus_tag="BSU_27620" /old_locus_tag="BSU27620" /EC_number="3.1.-.-" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:21087930, 21170359, 26001966" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21087930, 21170359, 26001966; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="single-strand DNA-specific exonuclease" /protein_id="NP_390640.1" /db_xref="EnsemblGenomes-Gn:BSU27620" /db_xref="EnsemblGenomes-Tr:CAB14721" /db_xref="GOA:O32044" /db_xref="InterPro:IPR001667" /db_xref="InterPro:IPR003156" /db_xref="InterPro:IPR004610" /db_xref="InterPro:IPR018779" /db_xref="SubtiList:BG13804" /db_xref="UniProtKB/Swiss-Prot:O32044" /translation="MLASKMRWEIQRPDQDKVKSLTEQLHITPLVASLLVKRGFDTAE SARLFLHTKDADFYDPFEMKGMKEAADRIKQAISQQEKIMIYGDYDADGVTSTSVMLH TLQKLSAQVDFYIPDRFKEGYGPNEQAFRSIKERGFSLIITVDTGIAAVHEAKVAKEL GLDVIITDHHEPGPELPDVRAIVHPKQPGCTYPFKELAGVGVAFKLAHALLGELPDEL LDLAAIGTIADLVPLHDENRLIATLGLERLRRTNRLGLKELIKLSGGDIGEANEETVG FQLAPRLNAVGRIEQADPAVHLLMSEDSFEAEELAAEIDQLNKERQKMVSKMTDEAIE MVEQQGLDQTAIVVAKAGWNPGVVGIVASKLVDRFYRPAIVLGIDEEKGIAKGSARSI RGFNLFESLSECRDILPHFGGHPMAAGMTLKAEDVPDLRSRLNEIADNTLTEEDFIPV QEVDLVCGVEDITVESIAEMNMLSPFGMLNPKPHVLVENAVLEDVRKIGANKTHVKMT IRNESSQLDCVGFNKGELQEGIVPGSRISIVGEMSINEWNNRKKPQLMIKDAAVSEWQ LFDLRGKRTWEDTVSALPSAKRAIVSFKEDSTTLLQTEDLRREVHVISSKDQAKAFDL DGAYIVLLDPPPSLDMLARLLEGKAPERIYFIFLNHEDHFLSTFPARDHFKWYYAFLL KRGAFDVKKHGSELAKHKGWSVETINFMTKVFFDLGFVKIENGVLSVVSGAKKRDLTD SQTYQAKQQLMELDQKLNYSSAEELKEWLNKLMKQDSEAYESTRRT*" /label="recJ CDS" gene complement(2474534..2476894) /gene="recJ" /locus_tag="BSU_27620" /old_locus_tag="BSU27620" /label="recJ gene" promotor_-10 complement(2474998..2475017) /Source="Nicolas_upshift_promotors" /id="U2131" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.95104895104895" /psig="0.95104895104895" /xcortree=754 /SigmaFactorBS="tgcacgtcatcagttctaaagatcaaGCAAAGGCGTttgacc tcgatggTGCATATATTGTATTACTGGatccgccgccttcgctggacatgctcgcacg t" /listShort="apt, S1045" /listLong="relA, dtd" /label="promotor_-10" upshifts complement(2475006) /Source="Nicolas_upshifts" /id="U2131" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.95104895104895" /psig="0.95104895104895" /xcortree=754 /SigmaFactorBS="tgcacgtcatcagttctaaagatcaaGCAAAGGCGTttgacc tcgatggTGCATATATTGTATTACTGGatccgccgccttcgctggacatgctcgcacg t" /listShort="apt, S1045" /listLong="relA, dtd" /label="upshifts" promotor_-35 complement(2475031..2475040) /Source="Nicolas_upshift_promotors" /id="U2131" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.95104895104895" /psig="0.95104895104895" /xcortree=754 /SigmaFactorBS="tgcacgtcatcagttctaaagatcaaGCAAAGGCGTttgacc tcgatggTGCATATATTGTATTACTGGatccgccgccttcgctggacatgctcgcacg t" /listShort="apt, S1045" /listLong="relA, dtd" /label="promotor_-35" promotor_-10 complement(2476908..2476927) /Source="Nicolas_upshift_promotors" /id="U2132" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.493506493506494" /psig=1 /xcortree=2600 /SigmaFactorBS="gattgagaaaaaagactagttttcgaatattATTTGAAaccc ctcagcctgcTCTAGTATAATAGGGTGGTTgaggggtgaatttatgttagcgtcaaaa a" /listShort="recJ, apt, S1045, relA, dtd" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2476919) /Source="Nicolas_upshifts" /id="U2132" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.493506493506494" /psig=1 /xcortree=2600 /SigmaFactorBS="gattgagaaaaaagactagttttcgaatattATTTGAAaccc ctcagcctgcTCTAGTATAATAGGGTGGTTgaggggtgaatttatgttagcgtcaaaa a" /listShort="recJ, apt, S1045, relA, dtd" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2476942..2476948) /Source="Nicolas_upshift_promotors" /id="U2132" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.493506493506494" /psig=1 /xcortree=2600 /SigmaFactorBS="gattgagaaaaaagactagttttcgaatattATTTGAAaccc ctcagcctgcTCTAGTATAATAGGGTGGTTgaggggtgaatttatgttagcgtcaaaa a" /listShort="recJ, apt, S1045, relA, dtd" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2476961..2477284) /gene="yrvD" /locus_tag="BSU_27630" /old_locus_tag="BSU27630" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390641.1" /db_xref="EnsemblGenomes-Gn:BSU27630" /db_xref="EnsemblGenomes-Tr:CAB14722" /db_xref="GOA:O32045" /db_xref="InterPro:IPR010445" /db_xref="SubtiList:BG13803" /db_xref="UniProtKB/Swiss-Prot:O32045" /translation="MNKQWTIIFALIFTLIVAIFAVINVRSVEVDYLFGRSEWPLILV ILGSVLMGALIVFSVGIFQVMKLKREIKTLRKENRTAIHKQEDTHLADQTDTQDASAM IEKKD*" /label="yrvD CDS" gene complement(2476961..2477284) /gene="yrvD" /locus_tag="BSU_27630" /old_locus_tag="BSU27630" /label="yrvD gene" promotor_-10 complement(2477305..2477323) /Source="Nicolas_upshift_promotors" /id="U2133" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=175 /SigmaFactorBS="cagcaaagggagcttaacctagtgttaagccaTGTTTAAaac cagtcttgattGGGAAAGTTACCTCAATAAgaagtttgggggaaaagagaatgaataa a" /listShort="yrvD, recJ, apt, S1045" /listLong="relA, dtd" /label="promotor_-10" upshifts complement(2477316) /Source="Nicolas_upshifts" /id="U2133" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=175 /SigmaFactorBS="cagcaaagggagcttaacctagtgttaagccaTGTTTAAaac cagtcttgattGGGAAAGTTACCTCAATAAgaagtttgggggaaaagagaatgaataa a" /listShort="yrvD, recJ, apt, S1045" /listLong="relA, dtd" /label="upshifts" promotor_-35 complement(2477338..2477344) /Source="Nicolas_upshift_promotors" /id="U2133" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=175 /SigmaFactorBS="cagcaaagggagcttaacctagtgttaagccaTGTTTAAaac cagtcttgattGGGAAAGTTACCTCAATAAgaagtttgggggaaaagagaatgaataa a" /listShort="yrvD, recJ, apt, S1045" /listLong="relA, dtd" /label="promotor_-35" CDS complement(2477360..2477857) /gene="yrvC" /locus_tag="BSU_27640" /old_locus_tag="BSU27640" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14563871; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative potassium transport accessory component" /protein_id="NP_390642.1" /db_xref="EnsemblGenomes-Gn:BSU27640" /db_xref="EnsemblGenomes-Tr:CAB14723" /db_xref="GOA:O32046" /db_xref="InterPro:IPR006037" /db_xref="InterPro:IPR026278" /db_xref="InterPro:IPR036721" /db_xref="SubtiList:BG13802" /db_xref="UniProtKB/Swiss-Prot:O32046" /translation="MRVRESELPGIGQKVEMITRNRDKISIIIHHDGRRELYYFDEND HEECVASVQFDDAEARQMSAILGGMAYKPKALEQVESALDDLIIEWCKAEAGAPAIHQ TIGDLNVGQEYHVTVIAIVKKNQDKQLNPSSETVIDEGDTLVISGEGTGLKRLIREKL TAKGA*" /label="yrvC CDS" gene complement(2477360..2477857) /gene="yrvC" /locus_tag="BSU_27640" /old_locus_tag="BSU27640" /label="yrvC gene" S_feature complement(2477858..2477933) /Source="Nicolas_S_feature" /locus_tag="new_2826743_2826818_c" /HighExp="Oxctl, HiOs, G180, LBGexp, Paraq, G150, G135, H2O2, MG-0.2, Mal" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1046" promotor_-10 complement(2477927..2477946) /Source="Nicolas_upshift_promotors" /id="U2134" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.485514485514486" /psig="0.999000999001" /xcortree=2308 /SigmaFactorBS="cagggcagcctgttttttgaagtttcATTGAACTtaaaatag acattTGCTATAATGACATACGCTTacatttaaacatatatatggtgttaaaagtgtt t" /listShort="S1046, yrvC, yrvD, recJ" /listLong="apt, S1045, relA, dtd" /label="promotor_-10" upshifts complement(2477933) /Source="Nicolas_upshifts" /id="U2134" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.485514485514486" /psig="0.999000999001" /xcortree=2308 /SigmaFactorBS="cagggcagcctgttttttgaagtttcATTGAACTtaaaatag acattTGCTATAATGACATACGCTTacatttaaacatatatatggtgttaaaagtgtt t" /listShort="S1046, yrvC, yrvD, recJ" /listLong="apt, S1045, relA, dtd" /label="upshifts" promotor_-35 complement(2477960..2477967) /Source="Nicolas_upshift_promotors" /id="U2134" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.485514485514486" /psig="0.999000999001" /xcortree=2308 /SigmaFactorBS="cagggcagcctgttttttgaagtttcATTGAACTtaaaatag acattTGCTATAATGACATACGCTTacatttaaacatatatatggtgttaaaagtgtt t" /listShort="S1046, yrvC, yrvD, recJ" /listLong="apt, S1045, relA, dtd" /label="promotor_-35" CDS complement(2478015..2480228) /gene="secDF" /locus_tag="BSU_27650" /old_locus_tag="BSU27650" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9694879, 15941986, 15995216, 16517687" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9694879, 15941986, 15995216, 16517687; Product type t: transporter" /codon_start=1 /transl_table=11 /product="protein-export membrane protein" /protein_id="NP_390643.1" /db_xref="EnsemblGenomes-Gn:BSU27650" /db_xref="EnsemblGenomes-Tr:CAB14724" /db_xref="GOA:O32047" /db_xref="InterPro:IPR005665" /db_xref="InterPro:IPR005791" /db_xref="InterPro:IPR022645" /db_xref="InterPro:IPR022646" /db_xref="InterPro:IPR022813" /db_xref="SubtiList:BG12672" /db_xref="UniProtKB/Swiss-Prot:O32047" /translation="MKKGRLIAFFLFVLLIGTGLGYFTKPAANNITLGLDLQGGFEVL YDVQPVKKGDKITKDVLVSTVEALNRRANVLGVSEPNIQIEGNNRIRVQLAGVTNQNR AREILATEAQLSFRDANDKELLNGADLVENGAKQTYDSTTNEPIVTIKLKDADKFGEV TKKVMKMAPNNQLVIWLDYDKGDSFKKEVQKEHPKFVSAPNVSQELNTTDVKIEGHFT AQEAKDLASILNAGALPVKLTEKYSTSVGAQFGQQALHDTVFAGIVGIAIIFLFMLFY YRLPGLIAVITLSVYIYITLQIFDWMNAVLTLPGIAALILGVGMAVDANIITYERIKE ELKLGKSVRSAFRSGNRRSFATIFDANITTIIAAVVLFIFGTSSVKGFATMLILSILT SFITAVFLSRFLLALLVESRWLDRKKGWFGVNKKHIMDIQDTDENTEPHTPFQKWDFT SKRKYFFIFSSAVTVAGIIILLVFRLNLGIDFASGARIEVQSDHKLTTEQVEKDFESL GMDPDTVVLSGEKSNIGVARFVGVPDKETIAKVKTYFKDKYGSDPNVSTVSPTVGKEL ARNALYAVAIASIGIIIYVSIRFEYKMAIAAIASLLYDAFFIVTFFSITRLEVDVTFI AAILTIIGYSINDTIVTFDRVREHMKKRKPKTFADLNHIVNLSLQQTFTRSINTVLTV VIVVVTLLIFGASSITNFSIALLVGLLTGVYSSLYIAAQIWLAWKGRELKKDSAQ*" /label="secDF CDS" gene complement(2478015..2480228) /gene="secDF" /locus_tag="BSU_27650" /old_locus_tag="BSU27650" /label="secDF gene" downshifts complement(2478020) /Source="Nicolas_upshifts" /id="D1416" /incds=0 /nref=174 /ntot=249 /MaxReadThrough="4.49738" /MaxDrop="5.0013" /score="29.1843057" /energy="-17.8" /TU="U2137" /idTUdmin="U2137" /TUdmin="-1100" /isTUend="FALSE" /label="downshifts" promotor_-35 2479787..2479792 /Source="Nicolas_upshift_promotors" /id="U2135" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.625374625374625" /psig="0.987012987012987" /xcortree=604 /SigmaFactorBS="caccaaatttatcagcgtctttcagcttaatcgTGACAAttg gctcatttgtTGTGCTATCATAAGTTTGTTtagcgccgttttcgactagatcagcacc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2479806..2479825 /Source="Nicolas_upshift_promotors" /id="U2135" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.625374625374625" /psig="0.987012987012987" /xcortree=604 /SigmaFactorBS="caccaaatttatcagcgtctttcagcttaatcgTGACAAttg gctcatttgtTGTGCTATCATAAGTTTGTTtagcgccgttttcgactagatcagcacc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2479814 /Source="Nicolas_upshifts" /id="U2135" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.625374625374625" /psig="0.987012987012987" /xcortree=604 /SigmaFactorBS="caccaaatttatcagcgtctttcagcttaatcgTGACAAttg gctcatttgtTGTGCTATCATAAGTTTGTTtagcgccgttttcgactagatcagcacc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2480267..2480563) /gene="comN" /locus_tag="BSU_27660" /old_locus_tag="BSU27660" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:19028902, 27059541" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19028902, 27059541; Product type r: regulator" /codon_start=1 /transl_table=11 /product="post-transcriptional regulator" /protein_id="NP_390644.1" /db_xref="EnsemblGenomes-Gn:BSU27660" /db_xref="EnsemblGenomes-Tr:CAB14726" /db_xref="GOA:O32049" /db_xref="InterPro:IPR025716" /db_xref="SubtiList:BG13814" /db_xref="UniProtKB/Swiss-Prot:O32049" /translation="MEKHPADLYKDHVRPFLYSKLEEFKILGYDDVELESLWSYLTDK KWKKKTELSIYELASDILSVKIGEFMNYATVESFKTSNWLGSEEGQEALEELLR*" /label="comN CDS" gene complement(2480267..2480563) /gene="comN" /locus_tag="BSU_27660" /old_locus_tag="BSU27660" /label="comN gene" downshifts 2480474 /Source="Nicolas_upshifts" /id="D1417" /incds=1 /nref=1 /ntot=66 /MaxReadThrough="1.36122" /MaxDrop="2.33158" /score="-9.07145122" /energy="-8.4" /TU="NA" /idTUdmin="U2136" /TUdmin="-2508" /isTUend="FALSE" /label="downshifts" S_feature complement(2480564..2480642) /Source="Nicolas_S_feature" /locus_tag="new_2829449_2829527_c" /HighExp="LBGtran, Lbtran, C90, M40t45, HiOs, Lbexp, Cold, M0t45, UNK1, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigH" /TUlongPSig=1 /label="S1047" promotor_-35 2480604..2480609 /Source="Nicolas_upshift_promotors" /id="U2136" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=986 /SigmaFactorBS="tccacgctccttttttattgtttttcaagaagacttGTCATG cttggacgacatatacGCATATCTTTATTGTATATgattccaggtagtttgagaaggc a" /listShort="spoVB, S1049" /listLong="yrzE" /label="promotor_-35" promotor_-10 2480626..2480644 /Source="Nicolas_upshift_promotors" /id="U2136" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=986 /SigmaFactorBS="tccacgctccttttttattgtttttcaagaagacttGTCATG cttggacgacatatacGCATATCTTTATTGTATATgattccaggtagtttgagaaggc a" /listShort="spoVB, S1049" /listLong="yrzE" /label="promotor_-10" promotor_-10 complement(2480628..2480647) /Source="Nicolas_upshift_promotors" /id="U2137" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.787212787212787" /psig=1 /xcortree=2330 /SigmaFactorBS="ctttaaaaacgtctgtttcgccatttttaccccctgcCTTCt caaactacctggaATCATATACAATAAAGATATgcgtatatgtcgtccaagcatgaca a" /listShort="S1047, comN, secDF, S1046, yrvC, yrvD" /listLong="recJ, apt, S1045, relA, dtd" /label="promotor_-10" upshifts 2480628 /Source="Nicolas_upshifts" /id="U2136" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=986 /SigmaFactorBS="tccacgctccttttttattgtttttcaagaagacttGTCATG cttggacgacatatacGCATATCTTTATTGTATATgattccaggtagtttgagaaggc a" /listShort="spoVB, S1049" /listLong="yrzE" /label="upshifts" upshifts complement(2480642) /Source="Nicolas_upshifts" /id="U2137" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.787212787212787" /psig=1 /xcortree=2330 /SigmaFactorBS="ctttaaaaacgtctgtttcgccatttttaccccctgcCTTCt caaactacctggaATCATATACAATAAAGATATgcgtatatgtcgtccaagcatgaca a" /listShort="S1047, comN, secDF, S1046, yrvC, yrvD" /listLong="recJ, apt, S1045, relA, dtd" /label="upshifts" S_feature complement(2480644..2481562) /Source="Nicolas_S_feature" /locus_tag="new_2829529_2830447_c" /HighExp="S2, M9-stat, Lbstat, BC, T2.0H, T3.0H, T2.30H, T3.30H, Cold, M0t90" /AntisenseName="spoVB" /AntisenseCor="-8.5173616652496897E-2" /AntisenseRegPval="-0.8" /CDS_PredictionProba="NA" /TUshortSig="SigH" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1048" promotor_-35 complement(2480662..2480665) /Source="Nicolas_upshift_promotors" /id="U2137" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.787212787212787" /psig=1 /xcortree=2330 /SigmaFactorBS="ctttaaaaacgtctgtttcgccatttttaccccctgcCTTCt caaactacctggaATCATATACAATAAAGATATgcgtatatgtcgtccaagcatgaca a" /listShort="S1047, comN, secDF, S1046, yrvC, yrvD" /listLong="recJ, apt, S1045, relA, dtd" /label="promotor_-35" CDS 2480679..2482235 /gene="spoVB" /locus_tag="BSU_27670" /old_locus_tag="BSU27670" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:1744050, 15292147, 15849754, 16850406, 17714441, 19648239" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1744050, 15292147, 15849754, 16850406, 17714441, 19648239; Product type t : transporter" /codon_start=1 /transl_table=11 /product="involved in spore cortex synthesis (stage V sporulation); translocase with flippase function for peptidoglycan synthesis" /protein_id="NP_390645.1" /db_xref="EnsemblGenomes-Gn:BSU27670" /db_xref="EnsemblGenomes-Tr:CAB14727" /db_xref="GOA:Q00758" /db_xref="InterPro:IPR002797" /db_xref="InterPro:IPR014249" /db_xref="InterPro:IPR024923" /db_xref="InterPro:IPR029303" /db_xref="SubtiList:BG10778" /db_xref="UniProtKB/Swiss-Prot:Q00758" /translation="MAKQTFLKGTLILIAAGMVTRMLGFVNRVVIARFIGEEGVGLYM MAAPTFFLATTLTQFGLPVAISKLVAEASARGDHQKTKNILVMSLTITGVLSLIFTPL FLFFAPVMAETMLTDKRTLYPLLAITPVVPIIAISSVLRGYFQGKQNMNPLAMSQVLE QVVRISLVAVCTTIFLPYGIEYAAAGAMLSSVAGELASLLYLFVCFKYKKTIKIRKHF LQSIKNGKQTFTQLMSVSLPTTGSRFIGNLSWFFEPIVVAQSLAIAGVATVAATKQYG ELTGFAMTLLTLPSFITYSLSTALVPAISEGMEQKKLQVVEYRLEQAMRLCLLSGGIS VVILFVFADELMRVMYGSSGAAVFIKVMAPFFLLYYFQGPLQAVLQALNLAGAAMMNS LIGALVKTGLIFVLATRPSLGIMGAALAIVTGMVLVTLLHAATVSKVLPISIKIKEYA LSFAVIVICGFISSAIKQYISFGASEAVNLAGWIAASAAIYMILLLVFRLIKKDELRR IPIIGRLIIR*" /label="spoVB CDS" gene 2480679..2482235 /gene="spoVB" /locus_tag="BSU_27670" /old_locus_tag="BSU27670" /label="spoVB gene" promotor_-10 complement(2481548..2481566) /Source="Nicolas_upshift_promotors" /id="U2138" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=549 /SigmaFactorBS="acctgcaattttttctgctccattccttcactgatcGCAGGA ACAagcgcggtcgaCAAAGAATATGTAATAAAGctgggcagagtcagcagcgtcatgg c" /listShort="S1048" /listLong="S1047, comN, secDF" /label="promotor_-10" upshifts complement(2481562) /Source="Nicolas_upshifts" /id="U2138" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=549 /SigmaFactorBS="acctgcaattttttctgctccattccttcactgatcGCAGGA ACAagcgcggtcgaCAAAGAATATGTAATAAAGctgggcagagtcagcagcgtcatgg c" /listShort="S1048" /listLong="S1047, comN, secDF" /label="upshifts" promotor_-35 complement(2481578..2481586) /Source="Nicolas_upshift_promotors" /id="U2138" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=549 /SigmaFactorBS="acctgcaattttttctgctccattccttcactgatcGCAGGA ACAagcgcggtcgaCAAAGAATATGTAATAAAGctgggcagagtcagcagcgtcatgg c" /listShort="S1048" /listLong="S1047, comN, secDF" /label="promotor_-35" S_feature 2482236..2483000 /Source="Nicolas_S_feature" /locus_tag="new_2831121_2831885" /HighExp="S3, BT, S4, LoTm, S7, S8, T5.0H, T4.0H, M9-stat, T3.30H" /AntisenseName="yrbG" /AntisenseCor="0.65629957843767395" /AntisenseRegPval="-33.799999999999997" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1049" CDS complement(2482239..2482895) /gene="yrbG" /locus_tag="BSU_27680" /old_locus_tag="BSU27680" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_390646.1" /db_xref="EnsemblGenomes-Gn:BSU27680" /db_xref="EnsemblGenomes-Tr:CAB14728" /db_xref="GOA:O32050" /db_xref="InterPro:IPR007353" /db_xref="InterPro:IPR023090" /db_xref="SubtiList:BG13786" /db_xref="UniProtKB/Swiss-Prot:O32050" /translation="MEELLTIAFRTVVLYFVILVIFRFMGKREIGELSILDLVVFIMM AEIAVLAIENVDDHLFHTILPMLVLMIIQVTLAYFSLKNRKVRQLLDGKPTIIIKYGK IDEEAMKSQRYNFDDLMVQLRENSIDRVADVSFAILEPSGKLTIVKKENSGEHRQLEM PLIIDGFIQTENLSRISKDRKWLLESLQKHGYTNPSDISFCSFTDGEIYIDEKDGHRT *" /label="yrbG CDS" gene complement(2482239..2482895) /gene="yrbG" /locus_tag="BSU_27680" /old_locus_tag="BSU27680" /label="yrbG gene" promotor_-10 complement(2482914..2482925) /Source="Nicolas_upshift_promotors" /id="U2139" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=940 /SigmaFactorBS="aattagacgtaaaagctttgtgaaatgcaatcggtttttctT ACATAAattgatcattttgTTGCAACCTATAatgagttggaggtgcataatggaagag c" /listShort="yrbG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2482926) /Source="Nicolas_upshifts" /id="U2139" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=940 /SigmaFactorBS="aattagacgtaaaagctttgtgaaatgcaatcggtttttctT ACATAAattgatcattttgTTGCAACCTATAatgagttggaggtgcataatggaagag c" /listShort="yrbG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2482939..2482945) /Source="Nicolas_upshift_promotors" /id="U2139" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=940 /SigmaFactorBS="aattagacgtaaaagctttgtgaaatgcaatcggtttttctT ACATAAattgatcattttgTTGCAACCTATAatgagttggaggtgcataatggaagag c" /listShort="yrbG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2482978..2482983 /Source="Nicolas_upshift_promotors" /id="U2140" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=977 /SigmaFactorBS="tgtaagaaaaaccgattgcatttcacaaagcttttaCGTCTA attcatgggataaggGAATACATTTTTACAAAGAcgagccatcagcatgtctgacggt t" /listShort="yrzE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2482999..2483017 /Source="Nicolas_upshift_promotors" /id="U2140" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=977 /SigmaFactorBS="tgtaagaaaaaccgattgcatttcacaaagcttttaCGTCTA attcatgggataaggGAATACATTTTTACAAAGAcgagccatcagcatgtctgacggt t" /listShort="yrzE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2483002 /Source="Nicolas_upshifts" /id="U2140" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=977 /SigmaFactorBS="tgtaagaaaaaccgattgcatttcacaaagcttttaCGTCTA attcatgggataaggGAATACATTTTTACAAAGAcgagccatcagcatgtctgacggt t" /listShort="yrzE" /GFF_Attribute="listLong" /label="upshifts" CDS 2483030..2483482 /gene="yrzE" /locus_tag="BSU_27690" /old_locus_tag="BSU27690" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_390647.1" /db_xref="EnsemblGenomes-Gn:BSU27690" /db_xref="EnsemblGenomes-Tr:CAB14729" /db_xref="GOA:O32051" /db_xref="InterPro:IPR023804" /db_xref="SubtiList:BG13815" /db_xref="UniProtKB/Swiss-Prot:O32051" /translation="MSDGFEQKEQKPFNTGREETIMEETKQVGKGILYGLIAIFSAML LTSLAVSLLLTATSLEESSFNWLITAISFLSLFIGGFISGGKGKERGWMIGALTALSF SLIILLFQYLGFGKTFTAEQLIFHLGFLGVCMLGGIFGVNMRGNRSST*" /label="yrzE CDS" gene 2483030..2483482 /gene="yrzE" /locus_tag="BSU_27690" /old_locus_tag="BSU27690" /label="yrzE gene" downshifts 2483466 /Source="Nicolas_upshifts" /id="D1418" /incds=0 /nref=39 /ntot=61 /MaxReadThrough="1.45569" /MaxDrop="7.7199" /score="41.7975947" /energy="-15" /TU="NA" /idTUdmin="U2140" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(2483521) /Source="Nicolas_upshifts" /id="D1419" /incds=0 /nref=188 /ntot=281 /MaxReadThrough="2.20451" /MaxDrop="7.91954" /score="33.5938356" /energy="-15" /TU="NA" /idTUdmin="U2141" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2483539..2483805) /gene="yrbF" /locus_tag="BSU_27700" /old_locus_tag="BSU27700" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10974125, 16166550, 21235483, 26790414; Product type t: transporter" /codon_start=1 /transl_table=11 /product="component of the preprotein translocase" /protein_id="NP_390648.2" /db_xref="EnsemblGenomes-Gn:BSU27700" /db_xref="EnsemblGenomes-Tr:CAB14730" /db_xref="GOA:O32052" /db_xref="InterPro:IPR003849" /db_xref="SubtiList:BG13785" /db_xref="UniProtKB/Swiss-Prot:O32052" /translation="MTGTLGTLVPIILMFAVLYFLLIRPQQKQQKAVRQMQEELKKGD SVVTIGGLHGTVDSIDESKVVIKTGDNTRLTFDRRAIREVSAAE*" /label="yrbF CDS" gene complement(2483539..2483805) /gene="yrbF" /locus_tag="BSU_27700" /old_locus_tag="BSU27700" /label="yrbF gene" CDS complement(2483842..2484987) /gene="tgt" /locus_tag="BSU_27710" /old_locus_tag="BSU27710" /EC_number="2.4.2.29" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12123838, 14660578, 16199558, 16206323; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA-guanine transglycosylase" /protein_id="NP_390649.1" /db_xref="EnsemblGenomes-Gn:BSU27710" /db_xref="EnsemblGenomes-Tr:CAB14731" /db_xref="GOA:O32053" /db_xref="InterPro:IPR002616" /db_xref="InterPro:IPR004803" /db_xref="InterPro:IPR036511" /db_xref="SubtiList:BG12686" /db_xref="UniProtKB/Swiss-Prot:O32053" /translation="MAEQPIRYEFIKECKQTGARLGKVHTPHGSFETPVFMPVGTLAT VKTMSPEELKAMDAGIILSNTYHLWLRPGQDIVKEAGGLHKFMNWDRAILTDSGGFQV FSLSKFRNIEEEGVHFRNHLNGDKLFLSPEKAMEIQNALGSDIMMAFDECPPYPAEYD YMKRSVERTSRWAERCLNAHNRQDEQGLFGIVQGGEYEDLRTQSAKDLISLDFPGYAI GGLSVGEPKDVMNRVLEFTTPLLPKDKPRYLMGVGSPDALIDGAIRGVDMFDCVLPTR IARNGTVFTAEGRLNMKNAKFERDFRPIDEECDCYTCKNYTRAYIRHLIRCNETFGLR LTTYHNLHFLLHLMEQVRQAIREDRLGDFREEFFERYGYNKPNAKSF*" /label="tgt CDS" gene complement(2483842..2484987) /gene="tgt" /locus_tag="BSU_27710" /old_locus_tag="BSU27710" /label="tgt gene" upshifts complement(2483894) /Source="Nicolas_upshifts" /id="U2141" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.432567432567433" /psig="0.164835164835165" /xcortree=2327 /SigmaFactorBS="tacacttaatggagcaggtaagacaggctattcgcgaggatc gtctgggtgatttcaGagaagagttctttgagcgttacggctataacaagccaaatgc g" /listShort="yrbF" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2483938) /Source="Nicolas_upshifts" /id="U2142" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.380619380619381" /psig="0.98901098901099" /xcortree=2457 /SigmaFactorBS="attcggccttcgattaacaACTTACcataaccttcatttTCT GTTACACTTAATGGAGCaggtaagacaggctattcgcgaggatcgtctgggtgatttc a" /listShort="yrbF" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2483940..2483959) /Source="Nicolas_upshift_promotors" /id="U2142" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.380619380619381" /psig="0.98901098901099" /xcortree=2457 /SigmaFactorBS="attcggccttcgattaacaACTTACcataaccttcatttTCT GTTACACTTAATGGAGCaggtaagacaggctattcgcgaggatcgtctgggtgatttc a" /listShort="yrbF" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2483974..2483979) /Source="Nicolas_upshift_promotors" /id="U2142" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.380619380619381" /psig="0.98901098901099" /xcortree=2457 /SigmaFactorBS="attcggccttcgattaacaACTTACcataaccttcatttTCT GTTACACTTAATGGAGCaggtaagacaggctattcgcgaggatcgtctgggtgatttc a" /listShort="yrbF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2485014..2486042) /gene="queA" /locus_tag="BSU_27720" /old_locus_tag="BSU27720" /EC_number="2.4.99.17" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 15822125, 17083917, 10739928" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 15822125, 17083917, 10739928; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="S-adenosylmethionine tRNA ribosyltransferase-isomerase" /protein_id="NP_390650.1" /db_xref="EnsemblGenomes-Gn:BSU27720" /db_xref="EnsemblGenomes-Tr:CAB14732" /db_xref="GOA:O32054" /db_xref="InterPro:IPR003699" /db_xref="InterPro:IPR036100" /db_xref="PDB:1YY3" /db_xref="SubtiList:BG12662" /db_xref="UniProtKB/Swiss-Prot:O32054" /translation="MKVDLFDFELPERLIAQVPLEQRDASRLMVLDKHTGELTDSSFK HIISFFNEGDCLVLNNTRVLPARLFGTKEDTGAKVELLLLKQETGDKWETLAKPAKRV KKGTVVTFGDGRLKAICTEELEHGGRKMEFQYDGIFYEVLESLGEMPLPPYIKEQLDD KERYQTVYSKEIGSAAAPTAGLHFTEEILQQLKDKGVQIEFITLHVGLGTFRPVSADE VEEHNMHAEFYQMSEETAAALNKVRENGGRIISVGTTSTRTLETIAGEHDGQFKASSG WTSIFIYPGYEFKAIDGMITNFHLPKSSLIMLVSALAGRENILRAYNHAVEEEYRFFS FGDAMLII*" /label="queA CDS" gene complement(2485014..2486042) /gene="queA" /locus_tag="BSU_27720" /old_locus_tag="BSU27720" /label="queA gene" CDS complement(2486072..2486272) /gene="yrzS" /locus_tag="BSU_27729" /old_locus_tag="BSU27729" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="YP_003097768.1" /db_xref="EnsemblGenomes-Gn:BSU27729" /db_xref="EnsemblGenomes-Tr:CAX52674" /db_xref="GOA:C0H463" /db_xref="InterPro:IPR021320" /db_xref="UniProtKB/Swiss-Prot:C0H463" /translation="MTEFPKIIMILGAVLLIIGAVLHFVGKMPGDIFVKKGNVTFFFP VVTCIIISVVLSILLNLFGRMK*" /label="yrzS CDS" gene complement(2486072..2486272) /gene="yrzS" /locus_tag="BSU_27729" /old_locus_tag="BSU27729" /label="yrzS gene" CDS complement(2486265..2487269) /gene="ruvB" /locus_tag="BSU_27730" /old_locus_tag="BSU27730" /EC_number="3.1.22.4" /function="16.6: Maintain" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 14701911, 15317759, 16267290, 19422832, 21600217, 24770420; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="Holliday junction DNA helicase, ATP-dependent component" /protein_id="YP_054590.1" /db_xref="EnsemblGenomes-Gn:BSU27730" /db_xref="EnsemblGenomes-Tr:CAB14733" /db_xref="GOA:O32055" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004605" /db_xref="InterPro:IPR008823" /db_xref="InterPro:IPR008824" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12669" /db_xref="UniProtKB/Swiss-Prot:O32055" /translation="MDERLVSSEADNHESVIEQSLRPQNLAQYIGQHKVKENLRVFID AAKMRQETLDHVLLYGPPGLGKTTLASIVANEMGVELRTTSGPAIERPGDLAAILTAL EPGDVLFIDEIHRLHRSIEEVLYPAMEDFCLDIVIGKGPSARSVRLDLPPFTLVGATT RVGLLTAPLRDRFGVMSRLEYYTQEELADIVTRTADVFEVEIDKPSALEIARRSRGTP RVANRLLRRVRDFAQVLGDSRITEDISQNALERLQVDRLGLDHIDHKLLMGMIEKFNG GPVGLDTISATIGEESHTIEDVYEPYLLQIGFIQRTPRGRIVTPAVYHHFQMEAPRYD *" /label="ruvB CDS" gene complement(2486265..2487269) /gene="ruvB" /locus_tag="BSU_27730" /old_locus_tag="BSU27730" /label="ruvB gene" CDS complement(2487280..2487885) /gene="ruvA" /locus_tag="BSU_27740" /old_locus_tag="BSU27740" /EC_number="3.1.22.4" /function="16.9: Replicate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:14701911, 15317759, 16267290, 24770420" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14701911, 15317759, 16267290, 24770420; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="Holliday junction DNA helicase" /protein_id="NP_390652.1" /db_xref="EnsemblGenomes-Gn:BSU27740" /db_xref="EnsemblGenomes-Tr:CAB14734" /db_xref="GOA:O05392" /db_xref="InterPro:IPR000085" /db_xref="InterPro:IPR003583" /db_xref="InterPro:IPR010994" /db_xref="InterPro:IPR011114" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR013849" /db_xref="InterPro:IPR036267" /db_xref="SubtiList:BG11973" /db_xref="UniProtKB/Swiss-Prot:O05392" /translation="MIEFVKGTIDYVSPQYIVIENGGIGYQIFTPNPFIYKERSQETI FTYHHIREDAFSLYGFSTREEKALFTKLLNVTGIGPKGALAILGSGDPGAVIQAIENE DEAFLVKFPGVGKKTARQIILDLKGKLADVVPEMIENLFNHEERLEKQTAETALEEAL EALRVLGYAEKEIKKVLPHLKEEIGLTTDQYVKKALQKLLK*" /label="ruvA CDS" gene complement(2487280..2487885) /gene="ruvA" /locus_tag="BSU_27740" /old_locus_tag="BSU27740" /label="ruvA gene" promotor_-10 complement(2487904..2487923) /Source="Nicolas_upshift_promotors" /id="U2143" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.915084915084915" /psig=1 /xcortree=2553 /SigmaFactorBS="aaagaatgagagagaagcgaacatatgttaacttttctatAA GACTTtggctgttttTATGGTACAATGAAGAACAGtcaaagaggtgaatttgcgtgat t" /listShort="ruvA, ruvB, yrzS, queA, tgt, yrbF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2487920) /Source="Nicolas_upshifts" /id="U2143" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.915084915084915" /psig=1 /xcortree=2553 /SigmaFactorBS="aaagaatgagagagaagcgaacatatgttaacttttctatAA GACTTtggctgttttTATGGTACAATGAAGAACAGtcaaagaggtgaatttgcgtgat t" /listShort="ruvA, ruvB, yrzS, queA, tgt, yrbF" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2487922..2488023) /Source="Nicolas_S_feature" /locus_tag="new_2836807_2836908_c" /HighExp="Etha, Heat, S8, S7, S4, S3, S6, S5, Salt, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigB" /TUshortPSig="0.997, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S1050" promotor_-35 complement(2487934..2487940) /Source="Nicolas_upshift_promotors" /id="U2143" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.915084915084915" /psig=1 /xcortree=2553 /SigmaFactorBS="aaagaatgagagagaagcgaacatatgttaacttttctatAA GACTTtggctgttttTATGGTACAATGAAGAACAGtcaaagaggtgaatttgcgtgat t" /listShort="ruvA, ruvB, yrzS, queA, tgt, yrbF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2488024..2488536) /gene="bofC" /locus_tag="BSU_27750" /old_locus_tag="BSU27750" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10931291, 16049010" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10931291, 16049010; Product type f: factor" /codon_start=1 /transl_table=11 /product="bypass of forespore C, intercompartmental signaling factor" /protein_id="NP_390653.1" /db_xref="EnsemblGenomes-Gn:BSU27750" /db_xref="EnsemblGenomes-Tr:CAB14735" /db_xref="GOA:O05391" /db_xref="InterPro:IPR015050" /db_xref="InterPro:IPR015071" /db_xref="PDB:2BW2" /db_xref="SubtiList:BG11917" /db_xref="UniProtKB/Swiss-Prot:O05391" /translation="MKRFSTAYLLLGILCSAAVFLIGAPSRALGAEVEHYEPLQVHVQ LEKVYLDGDVSIEHKHEKVFSMDDFWAAYAGWTLVEQKKGYVLFRKQMDDISPLSKVN GYIGVSDNGVISTFHGRPEPASEPIQSFFQIDLERLESHMQKNLLKGIPFRTKAEFED VIEHMKTYSG*" /label="bofC CDS" gene complement(2488024..2488536) /gene="bofC" /locus_tag="BSU_27750" /old_locus_tag="BSU27750" /label="bofC gene" promotor_-10 complement(2488565..2488576) /Source="Nicolas_upshift_promotors" /id="U2144" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1133 /SigmaFactorBS="gaacggtttgtcagggaaaatgtgcagacaaattttgataaa aCGGTTAAgcagtagcctctttGGTCAAACTAATcataaacgtgtgcaaagaggtgta g" /listShort="bofC, S1050, ruvA, ruvB" /listLong="yrzS, queA, tgt, yrbF" /label="promotor_-10" upshifts complement(2488580) /Source="Nicolas_upshifts" /id="U2144" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1133 /SigmaFactorBS="gaacggtttgtcagggaaaatgtgcagacaaattttgataaa aCGGTTAAgcagtagcctctttGGTCAAACTAATcataaacgtgtgcaaagaggtgta g" /listShort="bofC, S1050, ruvA, ruvB" /listLong="yrzS, queA, tgt, yrbF" /label="upshifts" CDS complement(2488584..2489891) /gene="csbX" /locus_tag="BSU_27760" /old_locus_tag="BSU27760" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9099855, 14638426, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative catecholate siderophose exporter" /protein_id="NP_390654.2" /db_xref="EnsemblGenomes-Gn:BSU27760" /db_xref="EnsemblGenomes-Tr:CAB14736" /db_xref="GOA:O05390" /db_xref="InterPro:IPR004748" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11922" /db_xref="UniProtKB/Swiss-Prot:O05390" /translation="MNTVHAKGNVLNKIGIPSHMVWGYIGVVIFMVGDGLEQGWLSPF LVDHGLSMQQSASLFTMYGIAVTISAWLSGTFVQTWGPRKTMTVGLLAFILGSAAFIG WAIPHMYYPALLGSYALRGLGYPLFAYSFLVWVSYSTSQNILGKAVGWFWFMFTCGLN VLGPFYSSYAVPAFGEINTLWSALLFVAAGGILALFFNKDKFTPIQKQDQPKWKELSK AFTIMFENPKVGIGGVVKTINAIGQFGFAIFLPTYLARYGYSVSEWLQIWGTLFFVNI VFNIIFGAVGDKLGWRNTVMWFGGVGCGIFTLALYYTPQLIGHQYWVLMIIACCYGAA LAGYVPLSALLPTLAPDNKGAAMSVLNLGSGLCAFIAPGIVSLFIGPLGAGGVIWIFA ALYFFSAFLTRFLTISEQSTDVYTEERFVRENVQTNFDKTVKQ*" /label="csbX CDS" gene complement(2488584..2489891) /gene="csbX" /locus_tag="BSU_27760" /old_locus_tag="BSU27760" /label="csbX gene" promotor_-35 complement(2488591..2488597) /Source="Nicolas_upshift_promotors" /id="U2144" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1133 /SigmaFactorBS="gaacggtttgtcagggaaaatgtgcagacaaattttgataaa aCGGTTAAgcagtagcctctttGGTCAAACTAATcataaacgtgtgcaaagaggtgta g" /listShort="bofC, S1050, ruvA, ruvB" /listLong="yrzS, queA, tgt, yrbF" /label="promotor_-35" downshifts complement(2489845) /Source="Nicolas_upshifts" /id="D1420" /incds=0 /nref=2 /ntot=80 /MaxReadThrough="7.18585" /MaxDrop="3.0235" /score="-6.29978124" /energy="-14.3" /TU="U2145,U2146" /idTUdmin="U2146" /TUdmin="-1793" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2489915..2489933) /Source="Nicolas_upshift_promotors" /id="U2145" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=262 /SigmaFactorBS="ttgagcacactgaaaaaatcgctttttaatctaacaGGATTA CaattcagcaagcttGGGTATATACTCCATTGATactttaagtaggcggtggagaaaa t" /listShort="csbX, bofC, S1050, ruvA, ruvB, yrzS, queA, tgt" /listLong="yrbF" /label="promotor_-10" upshifts complement(2489930) /Source="Nicolas_upshifts" /id="U2145" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=262 /SigmaFactorBS="ttgagcacactgaaaaaatcgctttttaatctaacaGGATTA CaattcagcaagcttGGGTATATACTCCATTGATactttaagtaggcggtggagaaaa t" /listShort="csbX, bofC, S1050, ruvA, ruvB, yrzS, queA, tgt" /listLong="yrbF" /label="upshifts" promotor_-35 complement(2489948..2489954) /Source="Nicolas_upshift_promotors" /id="U2145" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=262 /SigmaFactorBS="ttgagcacactgaaaaaatcgctttttaatctaacaGGATTA CaattcagcaagcttGGGTATATACTCCATTGATactttaagtaggcggtggagaaaa t" /listShort="csbX, bofC, S1050, ruvA, ruvB, yrzS, queA, tgt" /listLong="yrbF" /label="promotor_-35" CDS complement(2489962..2490987) /gene="yrbE" /locus_tag="BSU_27770" /old_locus_tag="BSU27770" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 28043209; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative inositol-related oxidoreductase" /protein_id="NP_390655.1" /db_xref="EnsemblGenomes-Gn:BSU27770" /db_xref="EnsemblGenomes-Tr:CAB14737" /db_xref="GOA:O05389" /db_xref="InterPro:IPR000683" /db_xref="InterPro:IPR004104" /db_xref="InterPro:IPR030827" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12280" /db_xref="UniProtKB/Swiss-Prot:O05389" /translation="MTKQIVTGIIGAGRIGKLHVQNISRIPHMKIKAISDIQASRIKS WADSHQIEYITSDYRDLLHDPDIDAIFICSPTAVHAQMIKEAAEAKKHIFCEKPVSFS LDETSEALAAVRKHGVTLQVGFNRRFDPHFKKIKTIVENGEIGTPHLLKITSRDPEPP NIDYVRTSGGLFMDMSIHDFDMARYIMGSEVTEVYAKGAALVNPSFAELGDIDTAVIT LTFENGAMAVIDNSRQAVYGYDQRVEVFGTKGSAAADNSRPTTVEVSTADFVMKDKPH FFFLERYKDSYEEEILRFAEAIGTNQETPCTGNDGLQAGRIARAAQQSLAFGMPVSIE HTEKIAF*" /label="yrbE CDS" gene complement(2489962..2490987) /gene="yrbE" /locus_tag="BSU_27770" /old_locus_tag="BSU27770" /label="yrbE gene" promotor_-10 complement(2491024..2491043) /Source="Nicolas_upshift_promotors" /id="U2146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=328 /SigmaFactorBS="gaattgtgataaaagagacatagaacgtttaatttccatTCT TGAAAagcgcttacaaatgGGATAGTATTAATTTTAAATaaagcgctttcgtgaatga t" /listShort="yrbE, csbX, bofC" /listLong="S1050, ruvA, ruvB" /label="promotor_-10" upshifts complement(2491044) /Source="Nicolas_upshifts" /id="U2146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=328 /SigmaFactorBS="gaattgtgataaaagagacatagaacgtttaatttccatTCT TGAAAagcgcttacaaatgGGATAGTATTAATTTTAAATaaagcgctttcgtgaatga t" /listShort="yrbE, csbX, bofC" /listLong="S1050, ruvA, ruvB" /label="upshifts" promotor_-35 complement(2491058..2491065) /Source="Nicolas_upshift_promotors" /id="U2146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=328 /SigmaFactorBS="gaattgtgataaaagagacatagaacgtttaatttccatTCT TGAAAagcgcttacaaatgGGATAGTATTAATTTTAAATaaagcgctttcgtgaatga t" /listShort="yrbE, csbX, bofC" /listLong="S1050, ruvA, ruvB" /label="promotor_-35" promotor_-35 2491113..2491120 /Source="Nicolas_upshift_promotors" /id="U2147" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig="0.997002997002997" /xcortree=1538 /SigmaFactorBS="ctatgtctcttttatcacaattcatgcttatAAGTAGCCttc ttcttcaagaCCAGATACACTAGAATTAGGctctttttcctgaacagtttatgatttt c" /listShort="yrzF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2491134..2491153 /Source="Nicolas_upshift_promotors" /id="U2147" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig="0.997002997002997" /xcortree=1538 /SigmaFactorBS="ctatgtctcttttatcacaattcatgcttatAAGTAGCCttc ttcttcaagaCCAGATACACTAGAATTAGGctctttttcctgaacagtttatgatttt c" /listShort="yrzF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2491142 /Source="Nicolas_upshifts" /id="U2147" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig="0.997002997002997" /xcortree=1538 /SigmaFactorBS="ctatgtctcttttatcacaattcatgcttatAAGTAGCCttc ttcttcaagaCCAGATACACTAGAATTAGGctctttttcctgaacagtttatgatttt c" /listShort="yrzF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2491174..2491179 /Source="Nicolas_upshift_promotors" /id="U2148" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1056 /SigmaFactorBS="tcaagaccagatacactagaattaggctctttttcctgaaca gtttATGATTttcctataaacagctGCATAAAATAGAGCAAAGAaggtgaatgaaatg c" /listShort="yrzF" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2491188 /Source="Nicolas_upshifts" /id="U2148" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1056 /SigmaFactorBS="tcaagaccagatacactagaattaggctctttttcctgaaca gtttATGATTttcctataaacagctGCATAAAATAGAGCAAAGAaggtgaatgaaatg c" /listShort="yrzF" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2491195..2491213 /Source="Nicolas_upshift_promotors" /id="U2148" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1056 /SigmaFactorBS="tcaagaccagatacactagaattaggctctttttcctgaaca gtttATGATTttcctataaacagctGCATAAAATAGAGCAAAGAaggtgaatgaaatg c" /listShort="yrzF" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2491225..2491872 /gene="yrzF" /locus_tag="BSU_27785" /old_locus_tag="BSU27785" /EC_number="2.7.11.1" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative serine/threonine-protein kinase" /protein_id="NP_390656.2" /db_xref="EnsemblGenomes-Gn:BSU27785" /db_xref="EnsemblGenomes-Tr:CAB14738" /db_xref="GOA:O32057" /db_xref="InterPro:IPR011009" /db_xref="InterPro:IPR017441" /db_xref="SubtiList:BG13816" /db_xref="UniProtKB/Swiss-Prot:O32057" /translation="MLTKAEALAHTVIYRKNSRFDKVKEKSEELTLIGKGRSAYVFAL TEGGRKMALKVFFPEYQATAVKEAAIYEKLAGSAFYPDIYETGDSFILMEYIKGETFY NCLKKGIAISDDMIQQVEEALSDARAAGLNPSDIHLRNLILTETGAVRVIDVARFEQT KTCTQWDDLKSAYHALYKKPIFPKKIPGFWLEIIAFLYKKDWFQKHFAQRKRKYS*" /label="yrzF CDS" gene 2491225..2491872 /gene="yrzF" /locus_tag="BSU_27785" /old_locus_tag="BSU27785" /label="yrzF gene" S_feature complement(2491547..2491880) /Source="Nicolas_S_feature" /locus_tag="new_2840432_2840765_c" /HighExp="LPhT, S8, BI, S7, S6, C30, Sw, BC, Gly, C90" /AntisenseName="yrzF" /AntisenseCor="0.348831504804749" /AntisenseRegPval="-8.4" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1051" downshifts 2491851 /Source="Nicolas_upshifts" /id="D1421" /incds=0 /nref=29 /ntot=228 /MaxReadThrough="2.4121" /MaxDrop="5.05737" /score="20.8102477" /energy="-18.2" /TU="NA" /idTUdmin="U2147" /TUdmin="-20" /isTUend="TRUE" /label="downshifts" S_feature complement(2491882..2492079) /Source="Nicolas_S_feature" /locus_tag="new_2840767_2840964_c" /HighExp="LPhT, BI, B60, S8, Gly, S7, S6, B36, S5, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99984200000000001" /TUshortSig="Sig-" /TUshortPSig="0.032" /TUlongSig="NA" /TUlongPSig="NA" /label="S1052" CDS complement(2491918..2492040) /locus_tag="BSU_27786" /old_locus_tag="BSU27786" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513992.1" /db_xref="EnsemblGenomes-Gn:BSU27786" /db_xref="EnsemblGenomes-Tr:CCQ48603" /db_xref="UniProtKB/TrEMBL:L8EAY3" /translation="MEKTYCHSGEKDPEAVYLTVRGYRIKLSPEQMKLISAVRK*" /label="hypothetical protein CDS" gene complement(2491918..2492040) /locus_tag="BSU_27786" /old_locus_tag="BSU27786" /label="gene" downshifts complement(2491925) /Source="Nicolas_upshifts" /id="D1422" /incds=0 /nref=3 /ntot=19 /MaxReadThrough="4.39913" /MaxDrop="4.52186" /score="39.5790138" /energy="-18.2" /TU="NA" /idTUdmin="U2149" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts complement(2492088) /Source="Nicolas_upshifts" /id="U2149" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.031968031968032" /xcortree=11 /SigmaFactorBS="cattttactatatatcggattcatataaTCTTTACAtttctt TAAAATTACCTCAATAAAgcaatgataagatgaaataaagccaataaagggtgagggg a" /listShort="S1052" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2492089..2492106) /Source="Nicolas_upshift_promotors" /id="U2149" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.031968031968032" /xcortree=11 /SigmaFactorBS="cattttactatatatcggattcatataaTCTTTACAtttctt TAAAATTACCTCAATAAAgcaatgataagatgaaataaagccaataaagggtgagggg a" /listShort="S1052" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2492113..2492120) /Source="Nicolas_upshift_promotors" /id="U2149" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.965034965034965" /psig="0.031968031968032" /xcortree=11 /SigmaFactorBS="cattttactatatatcggattcatataaTCTTTACAtttctt TAAAATTACCTCAATAAAgcaatgataagatgaaataaagccaataaagggtgagggg a" /listShort="S1052" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2492125..2492415 /gene="yrzH" /locus_tag="BSU_27800" /old_locus_tag="BSU27800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_390658.2" /db_xref="EnsemblGenomes-Gn:BSU27800" /db_xref="EnsemblGenomes-Tr:CAB14740" /db_xref="SubtiList:BG13818" /db_xref="UniProtKB/Swiss-Prot:O32059" /translation="MNPIYSKMREKKGESHIKTENTLSLDAARGELVNEKTLVKRTIY WNYPDSRPAVTWINHNTVKIGNQTLHLDTDETYDWRKDDHWIREEPPQASVR*" /label="yrzH CDS" gene 2492125..2492415 /gene="yrzH" /locus_tag="BSU_27800" /old_locus_tag="BSU27800" /label="yrzH gene" misc_feature 2492136..2492155 /Source="Nicolas_upshift_promotors" /id="U2150" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.462537462537463" /psig="0.903096903096903" /xcortree=657 /SigmaFactorBS="atcttatcattgctttattgaggtaattttaaagaaatgtaa agattatatgaatccgatATATAGTAAAATGAGAGAAAaaaagggagagagtcacatt a" /listShort="S1053, yrzH, yrzT" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 2492136..2492283 /Source="Nicolas_S_feature" /locus_tag="new_2841021_2841168" /HighExp="T3.30H, T4.0H, T3.0H, T2.0H, T2.30H, T5.0H, M9-stat, S7, T1.30H, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99999400000000005" /TUshortSig="SigA" /TUshortPSig="0.903" /TUlongSig="NA" /TUlongPSig="NA" /label="S1053" upshifts 2492136 /Source="Nicolas_upshifts" /id="U2150" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.462537462537463" /psig="0.903096903096903" /xcortree=657 /SigmaFactorBS="atcttatcattgctttattgaggtaattttaaagaaatgtaa agattatatgaatccgatATATAGTAAAATGAGAGAAAaaaagggagagagtcacatt a" /listShort="S1053, yrzH, yrzT" /GFF_Attribute="listLong" /label="upshifts" CDS 2492422..2492562 /gene="yrzT" /locus_tag="BSU_27809" /old_locus_tag="BSU27809" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097769.1" /db_xref="EnsemblGenomes-Gn:BSU27809" /db_xref="EnsemblGenomes-Tr:CAX52675" /db_xref="GOA:C0H464" /db_xref="UniProtKB/Swiss-Prot:C0H464" /translation="MNKMNGTNDEKHFNHFVIALSFIYGLTELGYLLLKDFITIAISL PL*" /label="yrzT CDS" gene 2492422..2492562 /gene="yrzT" /locus_tag="BSU_27809" /old_locus_tag="BSU27809" /label="yrzT gene" downshifts 2492551 /Source="Nicolas_upshifts" /id="D1423" /incds=0 /nref=139 /ntot=241 /MaxReadThrough="0.64189" /MaxDrop="4.74983" /score="23.2933855" /energy="-9.9" /TU="NA" /idTUdmin="U2150" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-35 2492611..2492617 /Source="Nicolas_upshift_promotors" /id="U2151" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1083 /SigmaFactorBS="cgtagtcgatacgccgcgttttttctttttcccttcctCTTC TTAttgataattacaggTCATATAATGTGACAAATCgattgtagaaatagttcgatta g" /listShort="yrbD, S1054" /GFF_Attribute="listLong" /label="promotor_-35" promotor_no_box 2492625..2492725 /Source="Nicolas_upshift_promotors" /id="U2152" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.383616383616384" /psig="0.376623376623377" /xcortree=317 /SigmaFactorBS="ttacaggtcatataatgtgacaaatcgattgtagaaatagtt cgattagaccaaaatcctttttatacatgtattcgaatttgaagtgagggggaagctt g" /listShort="yrbD" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-10 2492632..2492650 /Source="Nicolas_upshift_promotors" /id="U2151" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1083 /SigmaFactorBS="cgtagtcgatacgccgcgttttttctttttcccttcctCTTC TTAttgataattacaggTCATATAATGTGACAAATCgattgtagaaatagttcgatta g" /listShort="yrbD, S1054" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2492633 /Source="Nicolas_upshifts" /id="U2151" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1083 /SigmaFactorBS="cgtagtcgatacgccgcgttttttctttttcccttcctCTTC TTAttgataattacaggTCATATAATGTGACAAATCgattgtagaaatagttcgatta g" /listShort="yrbD, S1054" /GFF_Attribute="listLong" /label="upshifts" upshifts 2492685 /Source="Nicolas_upshifts" /id="U2152" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.383616383616384" /psig="0.376623376623377" /xcortree=317 /SigmaFactorBS="ttacaggtcatataatgtgacaaatcgattgtagaaatagtt cgattagaccaaaatcctttttatacatgtattcgaatttgaagtgagggggaagctt g" /listShort="yrbD" /GFF_Attribute="listLong" /label="upshifts" CDS 2492726..2494180 /gene="alaP" /locus_tag="BSU_27810" /old_locus_tag="BSU27810" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 1400476, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="sodium/proton-dependent alanine transporter" /protein_id="NP_390659.2" /db_xref="EnsemblGenomes-Gn:BSU27810" /db_xref="EnsemblGenomes-Tr:CAB14741" /db_xref="GOA:O32060" /db_xref="InterPro:IPR001463" /db_xref="SubtiList:BG13784" /db_xref="UniProtKB/Swiss-Prot:O32060" /translation="MADFVASLNAVLWSTPVIYILLGIGFAFSIMTRFLQVRHLKEMI VQMFKGKSSEAGVSSFQALSIALSGRVGTGNIAGVATAIAFGGPGAVFWMWAIAFIGA ASAFVESTLAQIYKVKQDGQYRGGPAYYIEKGLGIKWFAVLFAAAALIAMAFLMPGVQ SNSIAAGIQNAFGISPFVTGCGLVLLLGFIIFGGVKRIANAAQMIVPFMAIGYILLSL IIIVMNVSELPAVISLIFKSAFALDSAFGGLIGMAISWGVKRGIYSNEAGQGTGPHPA AAAEVSHPVKQGLVQAFSVYIDTLFVCSATAFMILFTGMYNTQAADGSFIVHQLKGVE AGPGFTQAAIDSVLPGFGAGFVAIALFFFAFTTIMAYYYIAETNIAYLARGRESKWAM LGLKLIILAATFYGTVKTASLAWALGDAGLGIMVWLNVIAIVLLAKPALLALKDYERQ KKQGLDPIFDPKALGIKNADFWEKEYTHESERVS*" /label="alaP CDS" gene 2492726..2494180 /gene="alaP" /locus_tag="BSU_27810" /old_locus_tag="BSU27810" /label="alaP gene" downshifts 2494181 /Source="Nicolas_upshifts" /id="D1424" /incds=0 /nref=6 /ntot=43 /MaxReadThrough="5.01314" /MaxDrop="4.4617" /score="6.86850608" /energy="-10.8" /TU="U2151" /idTUdmin="U2152" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2494221..2494943) /gene="yrbC" /locus_tag="BSU_27820" /old_locus_tag="BSU27820" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12060744, 18641136, 20647113; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative factor regulating gene expression" /protein_id="NP_390660.1" /db_xref="EnsemblGenomes-Gn:BSU27820" /db_xref="EnsemblGenomes-Tr:CAB14742" /db_xref="GOA:P94447" /db_xref="InterPro:IPR002876" /db_xref="InterPro:IPR017856" /db_xref="InterPro:IPR026564" /db_xref="InterPro:IPR029072" /db_xref="SubtiList:BG13783" /db_xref="UniProtKB/Swiss-Prot:P94447" /translation="MAGHSKWKNIQKRKNAQDAKRGKIFMKLAKEIYVAAKEGGADPE ANSALRLVIEKAKGANMPNENIDRAIKKAAGGQDGSSYEEITYEGYGPSGIAVMVECV TDNKNRTASNVRTAFNKNGGSLGESGCVAFLFERKGFITIDRTERQIEEDELMLDVLE AGGEELRIEEDLYEVFTEPEHFEEVKTALESKYLISSAEVTMLPNTYAEADDQAVEKL ETLIDVLEDDDDVQEVYTNYRS*" /label="yrbC CDS" gene complement(2494221..2494943) /gene="yrbC" /locus_tag="BSU_27820" /old_locus_tag="BSU27820" /label="yrbC gene" S_feature 2494226..2494647 /Source="Nicolas_S_feature" /locus_tag="new_2843111_2843532" /HighExp="S8, S6, S7, BT, C30, S5, S4, LoTm, C90, S3" /AntisenseName="yrbC" /AntisenseCor="-8.4330852334841305E-2" /AntisenseRegPval="-0.8" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S1054" downshifts complement(2494237) /Source="Nicolas_upshifts" /id="D1425" /incds=0 /nref=11 /ntot=164 /MaxReadThrough="3.2014" /MaxDrop="3.66865" /score="23.9031001" /energy="-16" /TU="U2153" /idTUdmin="U2153" /TUdmin="-574" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2494966..2494985) /Source="Nicolas_upshift_promotors" /id="U2153" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=1965 /SigmaFactorBS="aggaagggctgccggaagtgatattcggcagccttttTCTTT GCAtcagcgaacatttCCCATTAAAGTGTACATAGAaaatgtaaaagaaggtgaaaac a" /listShort="yrbC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2494983) /Source="Nicolas_upshifts" /id="U2153" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=1965 /SigmaFactorBS="aggaagggctgccggaagtgatattcggcagccttttTCTTT GCAtcagcgaacatttCCCATTAAAGTGTACATAGAaaatgtaaaagaaggtgaaaac a" /listShort="yrbC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2494999..2495006) /Source="Nicolas_upshift_promotors" /id="U2153" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=1965 /SigmaFactorBS="aggaagggctgccggaagtgatattcggcagccttttTCTTT GCAtcagcgaacatttCCCATTAAAGTGTACATAGAaaatgtaaaagaaggtgaaaac a" /listShort="yrbC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2495046..2495642) /gene="sgpA" /locus_tag="BSU_27830" /old_locus_tag="BSU27830" /function="16.13: Shape" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9770294, 10438771, 12562816, 17322312" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9770294, 10438771, 12562816, 17322312; Product type f: factor" /codon_start=1 /transl_table=11 /product="spore germination protein" /protein_id="NP_390661.2" /db_xref="EnsemblGenomes-Gn:BSU27830" /db_xref="EnsemblGenomes-Tr:CAB14743" /db_xref="GOA:P94446" /db_xref="InterPro:IPR019076" /db_xref="SubtiList:BG13782" /db_xref="UniProtKB/Swiss-Prot:P94446" /translation="MGKKMTIASLILMTAGLTACGANDNAMNDTRNNGNTRPIGYYTN ENDADRQGDGIDHDGPVSELMEDQNDGNRNTTNVNNRDRVTADDRVPLATDGTYNNTN NRNMNRNAANNGYDNQENRRLAAKIANRVKQVKNVNDTQVMVSDDRVVIAVKSHREFT KSDRDNVVKAARNYANGRDVQVSTDKGLFRKLHKMNNR*" /label="sgpA CDS" gene complement(2495046..2495642) /gene="sgpA" /locus_tag="BSU_27830" /old_locus_tag="BSU27830" /label="sgpA gene" downshifts complement(2495061) /Source="Nicolas_upshifts" /id="D1426" /incds=0 /nref=96 /ntot=172 /MaxReadThrough="2.47709" /MaxDrop="7.18444" /score="23.9031001" /energy="-16" /TU="NA" /idTUdmin="U2154" /TUdmin="-12" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2495685..2495696) /Source="Nicolas_upshift_promotors" /id="U2154" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=845 /SigmaFactorBS="cagatcactgccaaatggagagaactgacaCGCTTAAcatgc cccccatacGCACATGATAAAagcgagcaaacatgctcaattcgtccacggggggttt t" /listShort="coxA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2495687) /Source="Nicolas_upshifts" /id="U2154" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=845 /SigmaFactorBS="cagatcactgccaaatggagagaactgacaCGCTTAAcatgc cccccatacGCACATGATAAAagcgagcaaacatgctcaattcgtccacggggggttt t" /listShort="coxA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2495689..2495753) /Source="Nicolas_S_feature" /locus_tag="new_2844574_2844638_c" /HighExp="B36, LoTm, S8, S6, S5, BT, B60, S4, S7, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigEF, SigA" /TUshortPSig="1, 0.999, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1055" promotor_-35 complement(2495711..2495717) /Source="Nicolas_upshift_promotors" /id="U2154" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=845 /SigmaFactorBS="cagatcactgccaaatggagagaactgacaCGCTTAAcatgc cccccatacGCACATGATAAAagcgagcaaacatgctcaattcgtccacggggggttt t" /listShort="coxA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2495790..2496953) /gene="safA" /locus_tag="BSU_27840" /old_locus_tag="BSU27840" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10438771, 10714986, 10714992, 11040425, 15901704, 26953338" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10438771, 10714986, 10714992, 11040425, 15901704, 26953338; Product type f : factor" /codon_start=1 /transl_table=11 /product="morphogenetic protein associated with SpoVID" /protein_id="NP_390662.1" /db_xref="EnsemblGenomes-Gn:BSU27840" /db_xref="EnsemblGenomes-Tr:CAB14744" /db_xref="GOA:O32062" /db_xref="InterPro:IPR014248" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG13781" /db_xref="UniProtKB/Swiss-Prot:O32062" /translation="MKIHIVQKGDSLWKIAEKYGVDVEEVKKLNTQLSNPDLIMPGMK IKVPSEGVPVRKEPKAGKSPAAGSVKQEHPYAKEKPKSVVDVEDTKPKEKKSMPYVPP MPNLQENVYPEADVNDYYDMKQLFQPWSPPKPEEPKKHHDGNMDHMYHMQDQFPQQEA MSNMENANYPNMPNMPKAPEVGGIEEENVHHTVPNMPMPAVQPYYHYPAHFVPCPVPV SPILPGSGLCYPYYPAQAYPMHPMHGYQPGFVSPQYDPGYENQHHENSHHGHYGSYGA PQYASPAYGSPYGHMPYGPYYGTPQVMGAYQPAAAHGYMPYKDHDDCGCDGDHQPYFS APGHSGMGAYGSPNMPYGTANPNPNPYSAGVSMPMTNQPSVNQMFGRPEEENE*" /label="safA CDS" gene complement(2495790..2496953) /gene="safA" /locus_tag="BSU_27840" /old_locus_tag="BSU27840" /label="safA gene" downshifts complement(2495798) /Source="Nicolas_upshifts" /id="D1427" /incds=0 /nref=34 /ntot=189 /MaxReadThrough="5.61903" /MaxDrop="3.9565" /score="38.1347732" /energy="-11.1" /TU="U2155,U2156,U2159" /idTUdmin="U2154" /TUdmin="-749" /isTUend="FALSE" /label="downshifts" S_feature complement(2496954..2497029) /Source="Nicolas_S_feature" /locus_tag="new_2845839_2845914_c" /HighExp="S5, S4, B36, LoTm, S3, B60, S7, S6, Pyr, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigEF, SigA" /TUshortPSig="1, 0.999, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1056" promotor_-10 complement(2497005..2497023) /Source="Nicolas_upshift_promotors" /id="U2155" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1106 /SigmaFactorBS="gaatgctttcgatcacgtagatcagaaatattttcccttcct ttaCTCATAacttcttttgttcagGCATATGTTGTGAAGAAACatattgtaatcacag c" /listShort="S1056, safA, S1055, coxA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2497029) /Source="Nicolas_upshifts" /id="U2155" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1106 /SigmaFactorBS="gaatgctttcgatcacgtagatcagaaatattttcccttcct ttaCTCATAacttcttttgttcagGCATATGTTGTGAAGAAACatattgtaatcacag c" /listShort="S1056, safA, S1055, coxA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2497039..2497044) /Source="Nicolas_upshift_promotors" /id="U2155" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1106 /SigmaFactorBS="gaatgctttcgatcacgtagatcagaaatattttcccttcct ttaCTCATAacttcttttgttcagGCATATGTTGTGAAGAAACatattgtaatcacag c" /listShort="S1056, safA, S1055, coxA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2497070..2498176) /gene="nadA" /locus_tag="BSU_27850" /old_locus_tag="BSU27850" /EC_number="2.5.1.72" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:15898769, 15937336, 15967443, 18959769, 26455817" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15898769, 15937336, 15967443, 18959769, 26455817; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="quinolinate synthetase" /protein_id="NP_390663.1" /db_xref="EnsemblGenomes-Gn:BSU27850" /db_xref="EnsemblGenomes-Tr:CAB14745" /db_xref="GOA:Q9KWZ1" /db_xref="InterPro:IPR003473" /db_xref="InterPro:IPR023515" /db_xref="InterPro:IPR036094" /db_xref="SubtiList:BG12629" /db_xref="UniProtKB/Swiss-Prot:Q9KWZ1" /translation="MSILDVIKQSNDMMPESYKELSRKDMETRVAAIKKKFGSRLFIP GHHYQKDEVIQFADQTGDSLQLAQVAEKNKEADYIVFCGVHFMAETADMLTSEQQTVV LPDMRAGCSMADMADMQQTNRAWKKLQHIFGDTIIPLTYVNSTAEIKAFVGKHGGATV TSSNAKKVLEWAFTQKKRILFLPDQHLGRNTAYDLGIALEDMAVWDPMKDELVAESGH TNVKVILWKGHCSVHEKFTTKNIHDMRERDPDIQIIVHPECSHEVVTLSDDNGSTKYI IDTINQAPAGSKWAIGTEMNLVQRIIHEHPDKQIESLNPDMCPCLTMNRIDLPHLLWS LEQIEKGEPSGVIKVPKAIQEDALLALNRMLSIT*" /label="nadA CDS" gene complement(2497070..2498176) /gene="nadA" /locus_tag="BSU_27850" /old_locus_tag="BSU27850" /label="nadA gene" promotor_-10 complement(2497752..2497770) /Source="Nicolas_upshift_promotors" /id="U2156" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1174 /SigmaFactorBS="gacatggctgacatgcagcagaccaatagggcatggaagaag cttcAGCATAtatttggagatacgaTCATACCTTTAACTTATGTgaactccactgcgg a" /listShort="S1056, safA, S1055, coxA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2497777) /Source="Nicolas_upshifts" /id="U2156" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1174 /SigmaFactorBS="gacatggctgacatgcagcagaccaatagggcatggaagaag cttcAGCATAtatttggagatacgaTCATACCTTTAACTTATGTgaactccactgcgg a" /listShort="S1056, safA, S1055, coxA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2497786..2497791) /Source="Nicolas_upshift_promotors" /id="U2156" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1174 /SigmaFactorBS="gacatggctgacatgcagcagaccaatagggcatggaagaag cttcAGCATAtatttggagatacgaTCATACCTTTAACTTATGTgaactccactgcgg a" /listShort="S1056, safA, S1055, coxA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2498088 /Source="Nicolas_upshifts" /id="U2157" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.993006993006993" /psig=0 /xcortree=25 /SigmaFactorBS="ttttgataatgatggcctggtataaagagcctgctgccgaac tttttcttaatggcggcaaCGCGcgtttccatatcctttctcgatagttctttataac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 2498089..2498092 /Source="Nicolas_upshift_promotors" /id="U2157" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.993006993006993" /psig=0 /xcortree=25 /SigmaFactorBS="ttttgataatgatggcctggtataaagagcctgctgccgaac tttttcttaatggcggcaaCGCGcgtttccatatcctttctcgatagttctttataac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(2498163..2499032) /gene="nadC" /locus_tag="BSU_27860" /old_locus_tag="BSU27860" /EC_number="2.4.2.19" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8419294, 28618168; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nicotinate-nucleotide pyrophosphorylase (quinolinate phosphoribosyltransferase)" /protein_id="NP_390664.1" /db_xref="EnsemblGenomes-Gn:BSU27860" /db_xref="EnsemblGenomes-Tr:CAB14746" /db_xref="GOA:P39666" /db_xref="InterPro:IPR002638" /db_xref="InterPro:IPR004393" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR022412" /db_xref="InterPro:IPR027277" /db_xref="InterPro:IPR036068" /db_xref="InterPro:IPR037128" /db_xref="SubtiList:BG10868" /db_xref="UniProtKB/Swiss-Prot:P39666" /translation="MNHLQLKKLLNHFFLEDIGTGDLTSQSIFGEQSCEAEIVAKSEG IFAGAAIIKEGFSLLDENVQSILHKKDGDMLHKGEVIAELHGPAAALLSGERVVLNLI QRLSGIATMTREAVRCLDDEQIKICDTRKTTPGLRMLEKYAVRAGGGYNHRFGLYDGI MIKDNHIAACGSILEACKKARQAAGHMVNIEVEIETEEQLREAIAAGADVIMFDNCPP DTVRHFAKLTPANIKTEASGGITLESLPAFKGTGVNYISLGFLTHSVKSLDISMDVTL SNESVEECCYVNS*" /label="nadC CDS" gene complement(2498163..2499032) /gene="nadC" /locus_tag="BSU_27860" /old_locus_tag="BSU27860" /label="nadC gene" downshifts 2498257 /Source="Nicolas_upshifts" /id="D1428" /incds=1 /nref=4 /ntot=107 /MaxReadThrough="0.495279999999999" /MaxDrop="3.83418" /score="-8.75482157" /energy="-7.4" /TU="NA" /idTUdmin="U2157" /TUdmin=6 /isTUend="TRUE" /label="downshifts" CDS complement(2498986..2500581) /gene="nadB" /locus_tag="BSU_27870" /old_locus_tag="BSU27870" /EC_number="1.4.3.16" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8444804, 16199587, 18959769" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8444804, 16199587, 18959769; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-aspartate oxidase" /protein_id="NP_390665.1" /db_xref="EnsemblGenomes-Gn:BSU27870" /db_xref="EnsemblGenomes-Tr:CAB14747" /db_xref="GOA:P38032" /db_xref="InterPro:IPR003953" /db_xref="InterPro:IPR005288" /db_xref="InterPro:IPR015939" /db_xref="InterPro:IPR027477" /db_xref="InterPro:IPR036188" /db_xref="InterPro:IPR037099" /db_xref="SubtiList:BG10867" /db_xref="UniProtKB/Swiss-Prot:P38032" /translation="MSKKTIAVIGSGAAALSLAAAFPPSYEVTVITKKSVKNSNSVYA QGGIAAAYAKDDSIEAHLEDTLYAGCGHNNLAIVADVLHDGKMMVQSLLERGFPFDRN ERGGVCLGREGAHSYNRIFHAGGDATGRLLIDYLLKRINSKIKLIENETAADLLIEDG RCIGVMTKDSKGRLKVRHADEVVLAAGGCGNLFLHHTNDLTVTGDGLSLAYRAGAELT DLEFTQFHPTLLVKNGVSYGLVSEAVRGEGGCLVDENGRRIMAERHPLGDLAPRDIVS RVIHEEMAKGNRVYIDFSAISDFETRFPTITAICEKAGIDIHSGKIPVAPGMHFLMGG VSVNRWGETTVPGLYAIGETACSGLHGANRLASNSLLEALVFGKRAAEHIIQKPVYNR QYQSGLETSVFYEVPDIEGHELQSKMTSHMSILREQSSLIELSIWLHTLPFQEVNVKD ITIRQMELSHLWQTAKLMTFSALLREESRGAHFRTDFPHAEVSWQGRQIVHTKKGTKI RKNEGIWNNESFTAEKITESLFS*" /label="nadB CDS" gene complement(2498986..2500581) /gene="nadB" /locus_tag="BSU_27870" /old_locus_tag="BSU27870" /label="nadB gene" promotor_-35 2500609..2500616 /Source="Nicolas_upshift_promotors" /id="U2158" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2916 /SigmaFactorBS="ctttttagacatatgccatcctcctgttgtttacacctgTCT TGACAcctatatttacacaaGGATAAAATAAACTCAAGAGttttttatggagaacgga t" /listShort="nifS, nadR, S1057" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2500609..2500628) /Source="Nicolas_upshift_promotors" /id="U2159" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.97002997002997" /psig="0.996003996003996" /xcortree=2917 /SigmaFactorBS="aataaatcatccggtcttcctccatccgttctccataaaaaa cTCTTGAGTttattttatccttgTGTAAATATAGGTGTCAAGAcaggtgtaaacaaca g" /listShort="nadB, nadC, nadA, S1056, safA, S1055, coxA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2500630 /Source="Nicolas_upshifts" /id="U2158" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2916 /SigmaFactorBS="ctttttagacatatgccatcctcctgttgtttacacctgTCT TGACAcctatatttacacaaGGATAAAATAAACTCAAGAGttttttatggagaacgga t" /listShort="nifS, nadR, S1057" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2500632..2500651 /Source="Nicolas_upshift_promotors" /id="U2158" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2916 /SigmaFactorBS="ctttttagacatatgccatcctcctgttgtttacacctgTCT TGACAcctatatttacacaaGGATAAAATAAACTCAAGAGttttttatggagaacgga t" /listShort="nifS, nadR, S1057" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2500633) /Source="Nicolas_upshifts" /id="U2159" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.97002997002997" /psig="0.996003996003996" /xcortree=2917 /SigmaFactorBS="aataaatcatccggtcttcctccatccgttctccataaaaaa cTCTTGAGTttattttatccttgTGTAAATATAGGTGTCAAGAcaggtgtaaacaaca g" /listShort="nadB, nadC, nadA, S1056, safA, S1055, coxA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2500643..2500650) /Source="Nicolas_upshift_promotors" /id="U2159" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.97002997002997" /psig="0.996003996003996" /xcortree=2917 /SigmaFactorBS="aataaatcatccggtcttcctccatccgttctccataaaaaa cTCTTGAGTttattttatccttgTGTAAATATAGGTGTCAAGAcaggtgtaaacaaca g" /listShort="nadB, nadC, nadA, S1056, safA, S1055, coxA" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2500684..2501871 /gene="nifS" /locus_tag="BSU_27880" /old_locus_tag="BSU27880" /EC_number="2.8.1.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8444804, 14567704, 16199587, 25447671, 26443755, 28882201" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8444804, 14567704, 16199587, 25447671, 26443755, 28882201; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="desulfurase involved in iron-sulfur clusters forNAD biosynthesis" /protein_id="NP_390666.1" /db_xref="EnsemblGenomes-Gn:BSU27880" /db_xref="EnsemblGenomes-Tr:CAB14748" /db_xref="GOA:P38033" /db_xref="InterPro:IPR000192" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR016454" /db_xref="InterPro:IPR020578" /db_xref="SubtiList:BG10866" /db_xref="UniProtKB/Swiss-Prot:P38033" /translation="MIYLDYAATTPICEEALTVYQKLSMDMYGNASSLHDAGGKAKHI LEYCREKIANIIGGEASGIYFTSGGTESNFLAIQSLLNGLPKTKRHFITTAMEHQSIH NCAAFLEQQGYDVTVIEPNEYGLITEEILLTHIRPETGLVSIQHANSETGIIQPIQHL SSYLHNKGILLHCDAVQTFGKIPINTKNLGVDALSMSSHKIHGPKGVGAVYIRPDVPW KPVYPLTTHEYGFRAGTVNVPGIGAFTAAAELIVSEMEKQISRNEALRTYFLDQIRIR SLPVTLAADTSKAECLPHIIGCFFHSFEGQYVMLECNRSNICISTGSACSAGYHGPSE TMKALRKTEQEALQFIRISFGRHTTAEQLEQLLHTFTVLWEQKKGEFDIDRRIKANGR QQA*" /label="nifS CDS" gene 2500684..2501871 /gene="nifS" /locus_tag="BSU_27880" /old_locus_tag="BSU27880" /label="nifS gene" promotor_-10 complement(2500685..2500704) /Source="Nicolas_upshift_promotors" /id="U2160" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1362 /SigmaFactorBS="atatccatactaagcttctgatatacagtaagggcTTCCTCA CAAataggcgttgtcgcTGCATAATCTAAATAAATCAtccggtcttcctccatccgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2500703) /Source="Nicolas_upshifts" /id="U2160" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1362 /SigmaFactorBS="atatccatactaagcttctgatatacagtaagggcTTCCTCA CAAataggcgttgtcgcTGCATAATCTAAATAAATCAtccggtcttcctccatccgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2500719..2500728) /Source="Nicolas_upshift_promotors" /id="U2160" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1362 /SigmaFactorBS="atatccatactaagcttctgatatacagtaagggcTTCCTCA CAAataggcgttgtcgcTGCATAATCTAAATAAATCAtccggtcttcctccatccgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2501586..2501591 /Source="Nicolas_upshift_promotors" /id="U2161" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.79020979020979" /psig=1 /xcortree=1922 /SigmaFactorBS="cttcgaaagcagaatgtcttccgcatattatagggtgttttt ttcaCTCATTtgaaggacaaTATGTTATGTTAGAATGTAAtcggagtaatatttgcat t" /listShort="nadR" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2501600 /Source="Nicolas_upshifts" /id="U2161" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.79020979020979" /psig=1 /xcortree=1922 /SigmaFactorBS="cttcgaaagcagaatgtcttccgcatattatagggtgttttt ttcaCTCATTtgaaggacaaTATGTTATGTTAGAATGTAAtcggagtaatatttgcat t" /listShort="nadR" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2501602..2501621 /Source="Nicolas_upshift_promotors" /id="U2161" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.79020979020979" /psig=1 /xcortree=1922 /SigmaFactorBS="cttcgaaagcagaatgtcttccgcatattatagggtgttttt ttcaCTCATTtgaaggacaaTATGTTATGTTAGAATGTAAtcggagtaatatttgcat t" /listShort="nadR" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2501831..2502373 /gene="niaR" /locus_tag="BSU_27890" /old_locus_tag="BSU27890" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16199587, 18276644" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16199587, 18276644; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of de novo NAD biosynthesis" /protein_id="NP_390667.2" /db_xref="EnsemblGenomes-Gn:BSU27890" /db_xref="EnsemblGenomes-Tr:CAB14749" /db_xref="GOA:P39667" /db_xref="InterPro:IPR004173" /db_xref="InterPro:IPR013196" /db_xref="InterPro:IPR026043" /db_xref="InterPro:IPR035922" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10865" /db_xref="UniProtKB/Swiss-Prot:P39667" /translation="MTEELKLMGANRRDQLLLWLKESKSPLTGGELAKKANVSRQVIV QDISLLKAKNVPIIATSQGYVYMDAAAQQHQQAERIIACLHGPERTEEELQLIVDEGV TVKDVKIEHPVYGDLTAAIQVGTRKEVSHFIKKINSTNAAYLSQLTDGVHLHTLTAPD EHRIDQACQALEEAGILIKD*" /label="niaR CDS" gene 2501831..2502373 /gene="niaR" /locus_tag="BSU_27890" /old_locus_tag="BSU27890" /label="niaR gene" downshifts 2502356 /Source="Nicolas_upshifts" /id="D1429" /incds=0 /nref=109 /ntot=246 /MaxReadThrough="3.55509" /MaxDrop="5.04771" /score="15.054047" /energy="-5.6" /TU="U2158" /idTUdmin="U2161" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" CDS complement(2502398..2503255) /gene="pheA" /locus_tag="BSU_27900" /old_locus_tag="BSU27900" /EC_number="4.2.1.51" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:104661, 114523" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 104661, 114523; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="prephenate dehydratase" /protein_id="NP_390668.1" /db_xref="EnsemblGenomes-Gn:BSU27900" /db_xref="EnsemblGenomes-Tr:CAB14750" /db_xref="GOA:P21203" /db_xref="InterPro:IPR001086" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR008242" /db_xref="InterPro:IPR018528" /db_xref="SubtiList:BG10914" /db_xref="UniProtKB/Swiss-Prot:P21203" /translation="MKVGYLGPAATFTHLAVSSCFQNGAEHVAYRTIPECIDAAVAGE VDFAFVPLENALEGSVNLTIDYLIHEQPLPIVGEMTLPIHQHLLVHPSRENAWKELDK IYSHSHAIAQCHKFLHRHFPSVPYEYANSTGAAAKFVSDHPELNIGVIANDMAASTYE LKIVKRDIQDYRDNHTRFVILSPDENISFEVNSKLSSRPKTTLMVMLPQDDQSGALHR VLSAFSWRNLNLSKIESRPTKTGLGHYFFIIDIEKAFDDVLIPGAMQELEALGCKVRL LGAYQSYQL*" /label="pheA CDS" gene complement(2502398..2503255) /gene="pheA" /locus_tag="BSU_27900" /old_locus_tag="BSU27900" /label="pheA gene" S_feature 2502401..2503110 /Source="Nicolas_S_feature" /locus_tag="new_2851286_2851995" /HighExp="S2, T-5.40H, T3.30H, T-4.40H, GM-0.2, GM-0.1, Pyr, T4.0H, T5.0H, GM 10" /AntisenseName="pheA" /AntisenseCor="-0.15664933741609299" /AntisenseRegPval="-2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1057" downshifts complement(2502418) /Source="Nicolas_upshifts" /id="D1430" /incds=0 /nref=173 /ntot=247 /MaxReadThrough="1.87872" /MaxDrop="5.15605" /score="13.965695" /energy="-5.6" /TU="NA" /idTUdmin="U2162" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2503272..2503715) /gene="thrR" /locus_tag="BSU_27910" /old_locus_tag="BSU27910" /experiment="publication(s) with functional evidences, PMID:2537815, 27260660" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2537815, 27260660; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of operons hom-thrCB and thrD" /protein_id="NP_390669.1" /db_xref="EnsemblGenomes-Gn:BSU27910" /db_xref="EnsemblGenomes-Tr:CAB14751" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR008310" /db_xref="SubtiList:BG10913" /db_xref="UniProtKB/Swiss-Prot:P21204" /translation="MKEETFYLVREDVLPDAMRKTLEVKKLLDRKKADSVADAVQKVD LSRSAFYKYRDAVFPFYTMVKEQIITLFFHLEDRSGALSQLLQAVADSGSNVLSIHQT IPLQGRANVTLSISTSAMEEDIHTLMNKLRKFDFVEKVEILGSGA*" /label="thrR CDS" gene complement(2503272..2503715) /gene="thrR" /locus_tag="BSU_27910" /old_locus_tag="BSU27910" /label="thrR gene" CDS complement(2503776..2505062) /gene="obgE" /locus_tag="BSU_27920" /old_locus_tag="BSU27920" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10781545, 12682299, 15325267, 15827604, 18689482, 20830302, 24844575, 26951678, 28357361" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10781545, 12682299, 15325267, 15827604, 18689482, 20830302, 24844575, 26951678, 28357361; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ppGpp-binding GTPase involved in cell portioning, DNA repair and ribosome assembly" /protein_id="NP_390670.1" /db_xref="EnsemblGenomes-Gn:BSU27920" /db_xref="EnsemblGenomes-Tr:CAB14752" /db_xref="GOA:P20964" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR006074" /db_xref="InterPro:IPR006169" /db_xref="InterPro:IPR014100" /db_xref="InterPro:IPR015349" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031167" /db_xref="InterPro:IPR035101" /db_xref="InterPro:IPR036346" /db_xref="InterPro:IPR036726" /db_xref="PDB:1LNZ" /db_xref="SubtiList:BG10337" /db_xref="UniProtKB/Swiss-Prot:P20964" /translation="MFVDQVKVYVKGGDGGNGMVAFRREKYVPKGGPAGGDGGKGGDV VFEVDEGLRTLMDFRYKKHFKAIRGEHGMSKNQHGRNADDMVIKVPPGTVVTDDDTKQ VIADLTEHGQRAVIARGGRGGRGNSRFATPANPAPQLSENGEPGKERYIVLELKVLAD VGLVGFPSVGKSTLLSVVSSAKPKIADYHFTTLVPNLGMVETDDGRSFVMADLPGLIE GAHQGVGLGHQFLRHIERTRVIVHVIDMSGLEGRDPYDDYLTINQELSEYNLRLTERP QIIVANKMDMPEAAENLEAFKEKLTDDYPVFPISAVTREGLRELLFEVANQLENTPEF PLYDEEELTQNRVMYTMENEEVPFNITRDPDGVFVLSGDSLERLFKMTDFSRDESVKR FARQMRGMGVDEALRERGAKDGDIIRLLEFEFEFID*" /label="obgE CDS" gene complement(2503776..2505062) /gene="obgE" /locus_tag="BSU_27920" /old_locus_tag="BSU27920" /label="obgE gene" CDS complement(2505096..2505674) /gene="spo0B" /locus_tag="BSU_27930" /old_locus_tag="BSU27930" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9443976, 9477965, 9726997, 9809070, 10997904, 16788205, 27679485" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9443976, 9477965, 9726997, 9809070, 10997904, 16788205, 27679485; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sporulation initiation phosphotransferase" /protein_id="NP_390671.1" /db_xref="EnsemblGenomes-Gn:BSU27930" /db_xref="EnsemblGenomes-Tr:CAB14753" /db_xref="GOA:P06535" /db_xref="InterPro:IPR016120" /db_xref="InterPro:IPR016122" /db_xref="InterPro:IPR037100" /db_xref="PDB:1F51" /db_xref="PDB:1IXM" /db_xref="PDB:2FTK" /db_xref="SubtiList:BG10336" /db_xref="UniProtKB/Swiss-Prot:P06535" /translation="MKDVSKNQEENISDTALTNELIHLLGHSRHDWMNKLQLIKGNLS LQKYDRVFEMIEEMVIDAKHESKLSNLKTPHLAFDFLTFNWKTHYMTLEYEVLGEIKD LSAYDQKLAKLMRKLFHLFDQAVSRESENHLTVSLQTDHPDRQLILYLDFHGAFADPS AFDDIRQNGYEDVDIMRFEITSHECLIEIGLD*" /label="spo0B CDS" gene complement(2505096..2505674) /gene="spo0B" /locus_tag="BSU_27930" /old_locus_tag="BSU27930" /label="spo0B gene" S_feature complement(2505675..2505740) /Source="Nicolas_S_feature" /locus_tag="new_2854560_2854625_c" /HighExp="Cold, H2O2, G135, Paraq, G180, Oxctl, G150, C30, LPh, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 1" /TUlongSig="SigEF" /TUlongPSig=1 /label="S1058" promotor_-10 complement(2505725..2505744) /Source="Nicolas_upshift_promotors" /id="U2162" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.522477522477522" /psig="0.997002997002997" /xcortree=3176 /SigmaFactorBS="gaaaaaaggaacatgatatttctgggaaaaacaatTGTTTTT CtaacaaagccttcTCTGTTATAATTCATAATACacacttatacagactcctaaataa g" /listShort="S1058, spo0B, obg, yszB, pheA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2505740) /Source="Nicolas_upshifts" /id="U2162" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.522477522477522" /psig="0.997002997002997" /xcortree=3176 /SigmaFactorBS="gaaaaaaggaacatgatatttctgggaaaaacaatTGTTTTT CtaacaaagccttcTCTGTTATAATTCATAATACacacttatacagactcctaaataa g" /listShort="S1058, spo0B, obg, yszB, pheA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2505742..2505959) /Source="Nicolas_S_feature" /locus_tag="new_2854627_2854844_c" /HighExp="Cold, G135, H2O2, Paraq, G180, Oxctl, G150, C30, LPh, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigEF" /TUlongPSig=1 /label="S1059" CDS 2505752..2505874 /locus_tag="BSU_27935" /old_locus_tag="BSU27935" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513993.1" /translation="MLEKQLFFPEISCSFFLALVDLQPGRTFYVLLLGEHIQWV*" /label="hypothetical protein CDS" gene 2505752..2505874 /locus_tag="BSU_27935" /old_locus_tag="BSU27935" /label="gene" promotor_-35 complement(2505758..2505765) /Source="Nicolas_upshift_promotors" /id="U2162" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.522477522477522" /psig="0.997002997002997" /xcortree=3176 /SigmaFactorBS="gaaaaaaggaacatgatatttctgggaaaaacaatTGTTTTT CtaacaaagccttcTCTGTTATAATTCATAATACacacttatacagactcctaaataa g" /listShort="S1058, spo0B, obg, yszB, pheA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2505995..2506279) /gene="rpmA" /locus_tag="BSU_27940" /old_locus_tag="BSU27940" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9000630, 9588797, 11399077, 12682299, 14586115, 17981968, 22720735, 24335279, 25388641, 27435445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9000630, 9588797, 11399077, 12682299, 14586115, 17981968, 22720735, 24335279, 25388641, 27435445; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosomal protein L27 (BL24)" /protein_id="NP_390672.1" /db_xref="EnsemblGenomes-Gn:BSU27940" /db_xref="EnsemblGenomes-Tr:CAB14754" /db_xref="GOA:P05657" /db_xref="InterPro:IPR001684" /db_xref="InterPro:IPR018261" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10335" /db_xref="UniProtKB/Swiss-Prot:P05657" /translation="MLRLDLQFFASKKGVGSTKNGRDSEAKRLGAKRADGQFVTGGSI LYRQRGTKIYPGENVGRGGDDTLFAKIDGTVKFERFGRDRKKVSVYPVAQ*" /label="rpmA CDS" gene complement(2505995..2506279) /gene="rpmA" /locus_tag="BSU_27940" /old_locus_tag="BSU27940" /label="rpmA gene" downshifts complement(2506004) /Source="Nicolas_upshifts" /id="D1431" /incds=0 /nref=212 /ntot=261 /MaxReadThrough="7.39131" /MaxDrop="7.26483" /score="32.4992871" /energy="-12.5" /TU="U2163" /idTUdmin="U2164" /TUdmin=1078 /isTUend="FALSE" /label="downshifts" CDS complement(2506292..2506630) /gene="rppA" /locus_tag="BSU_27950" /old_locus_tag="BSU27950" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11567142, 22333191, 25388641, 27435445, 28187498; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribosomal protein L27 specific N-terminal end cysteine protease" /protein_id="NP_390673.2" /db_xref="EnsemblGenomes-Gn:BSU27950" /db_xref="EnsemblGenomes-Tr:CAB14755" /db_xref="InterPro:IPR007422" /db_xref="InterPro:IPR036764" /db_xref="SubtiList:BG10334" /db_xref="UniProtKB/Swiss-Prot:P26942" /translation="MIQATIRRSHDKGILSFEMTGHANFAEHGQDLVCAGVTAVVFGA VNAVIVLAGFEPLLDIGEDGGYFYFEFPESLDPEARQKAQLLIEGMIVSLETIERDYK DNLRVTTNII*" /label="rppA CDS" gene complement(2506292..2506630) /gene="rppA" /locus_tag="BSU_27950" /old_locus_tag="BSU27950" /label="rppA gene" CDS complement(2506633..2506941) /gene="rplU" /locus_tag="BSU_27960" /old_locus_tag="BSU27960" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8223574, 12682299, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8223574, 12682299, 22720735; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L21 (BL20)" /protein_id="NP_390674.1" /db_xref="EnsemblGenomes-Gn:BSU27960" /db_xref="EnsemblGenomes-Tr:CAB14756" /db_xref="GOA:P26908" /db_xref="InterPro:IPR001787" /db_xref="InterPro:IPR018258" /db_xref="InterPro:IPR028909" /db_xref="InterPro:IPR036164" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10333" /db_xref="UniProtKB/Swiss-Prot:P26908" /translation="MYAIIKTGGKQIKVEEGQTVYIEKLAAEAGETVTFEDVLFVGGD NVKVGNPTVEGATVTAKVEKQGRAKKITVFRYKPKKNVHKKQGHRQPYTKVTIEKINA *" /label="rplU CDS" gene complement(2506633..2506941) /gene="rplU" /locus_tag="BSU_27960" /old_locus_tag="BSU27960" /label="rplU gene" misc_RNA complement(2506955..2507030) /gene="ldlU" /locus_tag="BSU_misc_RNA_43" /product="ribosomal protein L21 leader mRNA sequence" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 27381917" /label="ldlU RNA" gene complement(2506955..2507030) /gene="ldlU" /locus_tag="BSU_misc_RNA_43" /label="ldlU gene" promotor_-10 complement(2507042..2507061) /Source="Nicolas_upshift_promotors" /id="U2163" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.848151848151848" /psig=1 /xcortree=2655 /SigmaFactorBS="attcttccatggaggaactgcttctgccctactaaaactgAT TGACAAacgccttgtatttTGGTATATTTTTTAATGTTAtggatgtagcaccattgct a" /listShort="NA, rplU, ysxB, rpmA, S1059, S1058, spo0B, obg, yszB, pheA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2507062) /Source="Nicolas_upshifts" /id="U2163" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.848151848151848" /psig=1 /xcortree=2655 /SigmaFactorBS="attcttccatggaggaactgcttctgccctactaaaactgAT TGACAAacgccttgtatttTGGTATATTTTTTAATGTTAtggatgtagcaccattgct a" /listShort="NA, rplU, ysxB, rpmA, S1059, S1058, spo0B, obg, yszB, pheA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2507075..2507082) /Source="Nicolas_upshift_promotors" /id="U2163" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.848151848151848" /psig=1 /xcortree=2655 /SigmaFactorBS="attcttccatggaggaactgcttctgccctactaaaactgAT TGACAAacgccttgtatttTGGTATATTTTTTAATGTTAtggatgtagcaccattgct a" /listShort="NA, rplU, ysxB, rpmA, S1059, S1058, spo0B, obg, yszB, pheA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2507088..2507954) /gene="spoIVFB" /locus_tag="BSU_27970" /old_locus_tag="BSU27970" /EC_number="3.4.24.-" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10809718, 11959848, 15087499, 16731018, 16816000, 16818230, 26953342, 29180425" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10809718, 11959848, 15087499, 16731018, 16816000, 16818230, 26953342, 29180425; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="membrane metalloprotease [proteolysis of pro-sigma(K)]" /protein_id="NP_390675.1" /db_xref="EnsemblGenomes-Gn:BSU27970" /db_xref="EnsemblGenomes-Tr:CAB14757" /db_xref="GOA:P26937" /db_xref="InterPro:IPR008915" /db_xref="SubtiList:BG10332" /db_xref="UniProtKB/Swiss-Prot:P26937" /translation="MNKWLDLILKIHVHPFLWIIAALGLLTGHMKALLCLLLIVLIHE LGHAALAVFFSWRIKRVFLLPFGGTVEVEEHGNRPLKEEFAVIIAGPLQHIWLQFAAW MLAEVSVIHQHTFELFTFYNLSILFVNLLPIWPLDGGKLLFLLFSKQLPFQKAHRLNL KTSLCFCLLLGCWVLFVIPLQISAWVLFVFLAVSLFEEYRQRHYIHVRFLLERYYGKN RELEKLLPLTVKAEDKVYHVMAEFKRGCKHPIIIEKSGQKLSQLDENEVLHAYFADKR TNSSMEELLLPY*" /label="spoIVFB CDS" gene complement(2507088..2507954) /gene="spoIVFB" /locus_tag="BSU_27970" /old_locus_tag="BSU27970" /label="spoIVFB gene" CDS complement(2507947..2508741) /gene="spoIVFA" /locus_tag="BSU_27980" /old_locus_tag="BSU27980" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10809718, 11959848, 15087499, 16731018, 16816000, 16818230, 17824930, 22882546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10809718, 11959848, 15087499, 16731018, 16816000, 16818230, 17824930, 22882546; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of SpoIVFB (stage IV sporulation)" /protein_id="NP_390676.1" /db_xref="EnsemblGenomes-Gn:BSU27980" /db_xref="EnsemblGenomes-Tr:CAB14758" /db_xref="GOA:P26936" /db_xref="InterPro:IPR011055" /db_xref="InterPro:IPR016047" /db_xref="SubtiList:BG10331" /db_xref="UniProtKB/Swiss-Prot:P26936" /translation="MSHRADEIRKRLEKRRKQLSGSKRFSTQTVSEKQKPPSWVMVTD QEKHGTLPVYEDNMPTFNGKHPLVKTDSIILKCLLSACLVLVSAIAYKTNIGPVSQIK PAVAKTFETEFQFASASHWFETKFGNPLAFLAPEHKNKEQQIEVGKDLIAPASGKVQQ DFQDNGEGIKVETSSDKIDSVKEGYVVEVSKDSQTGLTVKVQHADNTYSIYGELKDVD VALYDFVDKGKKLGSIKLDDHNKGVYYFAMKDGDKFIDPIQVISFE*" /label="spoIVFA CDS" gene complement(2507947..2508741) /gene="spoIVFA" /locus_tag="BSU_27980" /old_locus_tag="BSU27980" /label="spoIVFA gene" downshifts 2508744 /Source="Nicolas_upshifts" /id="D1432" /incds=0 /nref=1 /ntot=7 /MaxReadThrough="1.00279" /MaxDrop="2.6024" /score="-6.66807377" /energy="-6.9" /TU="NA" /idTUdmin="U2165" /TUdmin="-131" /isTUend="FALSE" /label="downshifts" promotor_no_box 2508750..2508850 /Source="Nicolas_upshift_promotors" /id="U2165" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.536463536463537" /psig="0.242757242757243" /xcortree=281 /SigmaFactorBS="tcctttgcattcgttgggtttgtacatcatatgtcttgtcca tggcaaatattcggtttagtcaagaacaaagcaggcaaaaacaaaaaaaacctgacac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-10 complement(2508765..2508783) /Source="Nicolas_upshift_promotors" /id="U2164" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=982 /SigmaFactorBS="tttgtttttgcctgctttgttcttgactaaacCGAATAtttg ccatggacaagACATATGATGTACAAACCCaacgaatgcaaaggatgatggcaatgag t" /listShort="spoIVFA, spoIVFB" /listLong="NA, rplU, ysxB, rpmA, S1059, S1058, spo0B, obg, yszB, pheA" /label="promotor_-10" upshifts complement(2508776) /Source="Nicolas_upshifts" /id="U2164" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=982 /SigmaFactorBS="tttgtttttgcctgctttgttcttgactaaacCGAATAtttg ccatggacaagACATATGATGTACAAACCCaacgaatgcaaaggatgatggcaatgag t" /listShort="spoIVFA, spoIVFB" /listLong="NA, rplU, ysxB, rpmA, S1059, S1058, spo0B, obg, yszB, pheA" /label="upshifts" promotor_-35 complement(2508799..2508804) /Source="Nicolas_upshift_promotors" /id="U2164" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=982 /SigmaFactorBS="tttgtttttgcctgctttgttcttgactaaacCGAATAtttg ccatggacaagACATATGATGTACAAACCCaacgaatgcaaaggatgatggcaatgag t" /listShort="spoIVFA, spoIVFB" /listLong="NA, rplU, ysxB, rpmA, S1059, S1058, spo0B, obg, yszB, pheA" /label="promotor_-35" upshifts 2508810 /Source="Nicolas_upshifts" /id="U2165" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.536463536463537" /psig="0.242757242757243" /xcortree=281 /SigmaFactorBS="tcctttgcattcgttgggtttgtacatcatatgtcttgtcca tggcaaatattcggtttagtcaagaacaaagcaggcaaaaacaaaaaaaacctgacac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2508853 /Source="Nicolas_upshifts" /id="D1433" /incds=0 /nref=2 /ntot=27 /MaxReadThrough="1.68429" /MaxDrop="7.01891" /score="-6.66807377" /energy="-6.9" /TU="U2165" /idTUdmin="U2165" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" downshifts complement(2508888) /Source="Nicolas_upshifts" /id="D1434" /incds=0 /nref=236 /ntot=262 /MaxReadThrough="2.68001" /MaxDrop="5.80551" /score="40.3102023" /energy="-12.6" /TU="U2166" /idTUdmin="U2167" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" CDS complement(2508891..2509697) /gene="minD" /locus_tag="BSU_27990" /old_locus_tag="BSU27990" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11886553, 12426398, 12492852, 12492861, 16322744, 16885474, 17513368, 19019154, 28674273" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11886553, 12426398, 12492852, 12492861, 16322744, 16885474, 17513368, 19019154, 28674273; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="ATPase activator of MinC" /protein_id="NP_390677.1" /db_xref="EnsemblGenomes-Gn:BSU27990" /db_xref="EnsemblGenomes-Tr:CAB14759" /db_xref="GOA:Q01464" /db_xref="InterPro:IPR002586" /db_xref="InterPro:IPR010223" /db_xref="InterPro:IPR025501" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10330" /db_xref="UniProtKB/Swiss-Prot:Q01464" /translation="MGEAIVITSGKGGVGKTTTSANLGTALAILGKRVCLVDTDIGLR NLDVVMGLENRIIYDLVDVVEGRCKMHQALVKDKRFDDLLYLMPAAQTSDKTAVAPEQ IKNMVQELKQEFDYVIIDCPAGIEQGYKNAVSGADKAIVVTTPEISAVRDADRIIGLL EQEENIEPPRLVVNRIRNHLMKNGDTMDIDEIVQHLSIDLLGIVADDDEVIKASNHGE PIAMDPKNRASIAYRNIARRILGESVPLQVLEEQNKGMMAKIKSFFGVRS*" /label="minD CDS" gene complement(2508891..2509697) /gene="minD" /locus_tag="BSU_27990" /old_locus_tag="BSU27990" /label="minD gene" CDS complement(2509699..2510379) /gene="minC" /locus_tag="BSU_28000" /old_locus_tag="BSU28000" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10411726, 12426398, 12446561, 15317782, 16322744, 17326815, 19141479, 20352045, 22720735, 24366721" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10411726, 12426398, 12446561, 15317782, 16322744, 17326815, 19141479, 20352045, 22720735, 24366721; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="cell-division regulator (septum placement)" /protein_id="NP_390678.1" /db_xref="EnsemblGenomes-Gn:BSU28000" /db_xref="EnsemblGenomes-Tr:CAB14760" /db_xref="GOA:Q01463" /db_xref="InterPro:IPR005526" /db_xref="InterPro:IPR013033" /db_xref="InterPro:IPR036145" /db_xref="PDB:2M4I" /db_xref="SubtiList:BG10329" /db_xref="UniProtKB/Swiss-Prot:Q01463" /translation="MKTKKQQYVTIKGTKNGLTLHLDDACSFDELLDGLQNMLSIEQY TDGKGQKISVHVKLGNRFLYKEQEEQLTELIASKKDLFVHSIDSEVITKKEAQQIREE AEIISVSKIVRSGQVLQVKGDLLLIGDVNPGGTVRAGGNIFVLGSLKGIAHAGFNGNN QAVIAASEMLPTQLRINHVLNRSPDHIQKGNEMECAYLDTDGNMVIERLQHLAHLRPD LTRLEGGM*" /label="minC CDS" gene complement(2509699..2510379) /gene="minC" /locus_tag="BSU_28000" /old_locus_tag="BSU28000" /label="minC gene" CDS complement(2510432..2510950) /gene="mreD" /locus_tag="BSU_28010" /old_locus_tag="BSU28010" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15849754, 16101995, 16850406, 18156271" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16101995, 16850406, 18156271; Product type s: structure" /codon_start=1 /transl_table=11 /product="cell-shape determining protein" /protein_id="NP_390679.1" /db_xref="EnsemblGenomes-Gn:BSU28010" /db_xref="EnsemblGenomes-Tr:CAB14761" /db_xref="GOA:Q01467" /db_xref="InterPro:IPR007227" /db_xref="SubtiList:BG10328" /db_xref="UniProtKB/Swiss-Prot:Q01467" /translation="MKRFLLPFVMMLVFSAESIFTDLVHFPFVTDDQVLAPRFLMLVL IFMSAFINQKHAMIYGFIFGFLYDMNYTSLLGVYMFGFAGLCYLASKAFKVLHTNAFV VILIAVLAVCLLEFYVFGIQSLIHKDIMTFNGFVLDRFIPTILLNIAAALILVLPFRL FFMSLKKELRDE*" /label="mreD CDS" gene complement(2510432..2510950) /gene="mreD" /locus_tag="BSU_28010" /old_locus_tag="BSU28010" /label="mreD gene" CDS complement(2510947..2511819) /gene="mreC" /locus_tag="BSU_28020" /old_locus_tag="BSU28020" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15849754, 16101995, 16850406, 17427287, 20623345" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16101995, 16850406, 17427287, 20623345; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="cell-shape determining protein" /protein_id="NP_390680.2" /db_xref="EnsemblGenomes-Gn:BSU28020" /db_xref="EnsemblGenomes-Tr:CAB14762" /db_xref="GOA:Q01466" /db_xref="InterPro:IPR007221" /db_xref="SubtiList:BG10327" /db_xref="UniProtKB/Swiss-Prot:Q01466" /translation="MPNKRLMLLLLCIIILVAMIGFSLKGGRNTTWPEKVIGDTTGVF QNIFHTPAEFFAGIFENINDLKNTYKENERLREKLDGQTQYEAKLQELEEENKSLRDE LGHVKSIKDYKPILATVIARSPDNWAKQVTINKGTQQNVAKDMAVTNEKGALIGKIKS SGLNNFTSAVQLLSDTDRNNRVATKISGKKGSKGYGLIEGYDKEKKRLKMTIIERKDK QDVKKGDLIETSGTGGVFPEGLTIGEVTDIESDSYGLTKVAYVKPAADLTDLNNVIVV NRDVPTVDTEEEGS*" /label="mreC CDS" gene complement(2510947..2511819) /gene="mreC" /locus_tag="BSU_28020" /old_locus_tag="BSU28020" /label="mreC gene" CDS complement(2511850..2512863) /gene="mreB" /locus_tag="BSU_28030" /old_locus_tag="BSU28030" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:14588250, 15745453, 15922599, 16322744, 16885474, 17064365, 17513368, 22166997, 24550515, 27376153, 28589952" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14588250, 15745453, 15922599, 16322744, 16885474, 17064365, 17513368, 22166997, 24550515, 27376153, 28589952; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="cell-shape determining protein" /protein_id="NP_390681.2" /db_xref="EnsemblGenomes-Gn:BSU28030" /db_xref="EnsemblGenomes-Tr:CAB14763" /db_xref="GOA:Q01465" /db_xref="InterPro:IPR004753" /db_xref="SubtiList:BG10326" /db_xref="UniProtKB/Swiss-Prot:Q01465" /translation="MFGIGARDLGIDLGTANTLVFVKGKGIVVREPSVVALQTDTKSI VAVGNDAKNMIGRTPGNVVALRPMKDGVIADYETTATMMKYYINQAIKNKGMFARKPY VMVCVPSGITAVEERAVIDATRQAGARDAYPIEEPFAAAIGANLPVWEPTGSMVVDIG GGTTEVAIISLGGIVTSQSIRVAGDEMDDAIINYIRKTYNLMIGDRTAEAIKMEIGSA EAPEESDNMEIRGRDLLTGLPKTIEITGKEISNALRDTVSTIVEAVKSTLEKTPPELA ADIMDRGIVLTGGGALLRNLDKVISEETKMPVLIAEDPLDCVAIGTGKALEHIHLFKG KTR*" /label="mreB CDS" gene complement(2511850..2512863) /gene="mreB" /locus_tag="BSU_28030" /old_locus_tag="BSU28030" /label="mreB gene" upshifts complement(2512904) /Source="Nicolas_upshifts" /id="U2166" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.380619380619381" /psig="0.897102897102897" /xcortree=2535 /SigmaFactorBS="atatttgtaacactttttttttcgtcgaatTAAGCTATAATA GAGTTTAtgagtttttccctttagggtatttttgctttaagaaaggaagatacataca t" /listShort="mreB, mreC, mreD, minC, minD" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(2512916..2512934) /Source="Nicolas_upshift_promotors" /id="U2166" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.380619380619381" /psig="0.897102897102897" /xcortree=2535 /SigmaFactorBS="atatttgtaacactttttttttcgtcgaatTAAGCTATAATA GAGTTTAtgagtttttccctttagggtatttttgctttaagaaaggaagatacataca t" /listShort="mreB, mreC, mreD, minC, minD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(2512955..2513650) /gene="ysxA" /locus_tag="BSU_28040" /old_locus_tag="BSU28040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10652786, 17434969, 18556794; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="conserved nucleotide-related metabolism protein" /protein_id="NP_390682.1" /db_xref="EnsemblGenomes-Gn:BSU28040" /db_xref="EnsemblGenomes-Tr:CAB14764" /db_xref="GOA:Q02170" /db_xref="InterPro:IPR000445" /db_xref="InterPro:IPR001405" /db_xref="InterPro:IPR010994" /db_xref="InterPro:IPR020891" /db_xref="InterPro:IPR025657" /db_xref="SubtiList:BG10325" /db_xref="UniProtKB/Swiss-Prot:Q02170" /translation="MVIHDLPLKLKDFPMKEKPRERLLKVGAENLANHELLAILLRTG TKHESVLDLSNRLLRSFDGLRLLKEASVEELSSIPGIGMVKAIQILAAVELGSRIHKL ANEEHFVIRSPEDGANLVMEDMRFLTQEHFVCLYLNTKNQVIHKRTVFIGSLNSSIVH PREVFKEAFKRSAASFICVHNHPSGDPTPSREDIEVTRRLFECGNLIGIELLDHLVIG DKKFVSLKEKGYL*" /label="ysxA CDS" gene complement(2512955..2513650) /gene="ysxA" /locus_tag="BSU_28040" /old_locus_tag="BSU28040" /label="ysxA gene" CDS complement(2513687..2514256) /gene="maf" /locus_tag="BSU_28050" /old_locus_tag="BSU28050" /EC_number="3.6.1.9" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10841541, 16216582, 21564336, 24210219" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10841541, 16216582, 21564336, 24210219; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nucleoside triphosphate pyrophosphatase; septum formation DNA-binding protein (multicopy associated filamentation)" /protein_id="NP_390683.1" /db_xref="EnsemblGenomes-Gn:BSU28050" /db_xref="EnsemblGenomes-Tr:CAB14765" /db_xref="GOA:Q02169" /db_xref="InterPro:IPR003697" /db_xref="InterPro:IPR029001" /db_xref="PDB:1EX2" /db_xref="PDB:1EXC" /db_xref="PDB:4HEB" /db_xref="SubtiList:BG10324" /db_xref="UniProtKB/Swiss-Prot:Q02169" /translation="MTKPLILASQSPRRKELLDLLQLPYSIIVSEVEEKLNRNFSPEE NVQWLAKQKAKAVADLHPHAIVIGADTMVCLDGECLGKPQDQEEAASMLRRLSGRSHS VITAVSIQAENHSETFYDKTEVAFWSLSEEEIWTYIETKEPMDKAGAYGIQGRGALFV KKIDGDYYSVMGLPISKTMRALRHFDIRA*" /label="maf CDS" gene complement(2513687..2514256) /gene="maf" /locus_tag="BSU_28050" /old_locus_tag="BSU28050" /label="maf gene" promotor_-10 complement(2514108..2514123) /Source="Nicolas_upshift_promotors" /id="U2167" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1656 /SigmaFactorBS="ttattgtcagtgaagtagaagaaaaattaaatCGAAACTTTT caccagaagaaaACGTCCAATGGTTGGCaaaacaaaaagctaaggctgtagctgatct c" /listShort="radC, mreB, mreC, mreD, minC, minD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2514117) /Source="Nicolas_upshifts" /id="U2167" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1656 /SigmaFactorBS="ttattgtcagtgaagtagaagaaaaattaaatCGAAACTTTT caccagaagaaaACGTCCAATGGTTGGCaaaacaaaaagctaaggctgtagctgatct c" /listShort="radC, mreB, mreC, mreD, minC, minD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2514136..2514145) /Source="Nicolas_upshift_promotors" /id="U2167" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1656 /SigmaFactorBS="ttattgtcagtgaagtagaagaaaaattaaatCGAAACTTTT caccagaagaaaACGTCCAATGGTTGGCaaaacaaaaagctaaggctgtagctgatct c" /listShort="radC, mreB, mreC, mreD, minC, minD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2514295..2514314) /Source="Nicolas_upshift_promotors" /id="U2168" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.296703296703297" /psig=1 /xcortree=2191 /SigmaFactorBS="ctttttttattttgtcatgaaaaagttatttttctgaAATTG TGacaagcctcgtgaTTTGGTAGGATAAACGAGTAtctttttttcttaagcaaaccct g" /listShort="maf, radC, mreB, mreC, mreD, minC, minD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2514311) /Source="Nicolas_upshifts" /id="U2168" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.296703296703297" /psig=1 /xcortree=2191 /SigmaFactorBS="ctttttttattttgtcatgaaaaagttatttttctgaAATTG TGacaagcctcgtgaTTTGGTAGGATAAACGAGTAtctttttttcttaagcaaaccct g" /listShort="maf, radC, mreB, mreC, mreD, minC, minD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2514328..2514334) /Source="Nicolas_upshift_promotors" /id="U2168" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.296703296703297" /psig=1 /xcortree=2191 /SigmaFactorBS="ctttttttattttgtcatgaaaaagttatttttctgaAATTG TGacaagcctcgtgaTTTGGTAGGATAAACGAGTAtctttttttcttaagcaaaccct g" /listShort="maf, radC, mreB, mreC, mreD, minC, minD" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2514407) /Source="Nicolas_upshifts" /id="D1435" /incds=0 /nref=41 /ntot=100 /MaxReadThrough="1.92542" /MaxDrop="5.77117" /score="8.94061802" /energy="-7.4" /TU="NA" /idTUdmin="U2169" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(2514409..2515407) /gene="spoIIB" /locus_tag="BSU_28060" /old_locus_tag="BSU28060" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16959571, 17376078, 22720735, 22882546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16959571, 17376078, 22720735, 22882546; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spatial and temporal regulator of the dissolution of septal peptidoglycan during engulfment (stage II sporulation)" /protein_id="NP_390684.1" /db_xref="EnsemblGenomes-Gn:BSU28060" /db_xref="EnsemblGenomes-Tr:CAB14766" /db_xref="GOA:P37575" /db_xref="InterPro:IPR007730" /db_xref="InterPro:IPR036680" /db_xref="SubtiList:BG10912" /db_xref="UniProtKB/Swiss-Prot:P37575" /translation="MKKRKNKKNSKAAEKALKVTINGKEETVYEQETPETEANKSMTF SNWEEKRQAEQEVAASQEHPDEDEFNWDSEEDKVFKEDPKVVPPFQKKKTKLYAKGKT GAAKPVKRVAATIAFAAVIGTGLGLFALNISGNKEASAPASLEDSLGSQTAKAGDTSA DKQTSGAEKQAAQTEGTYKTYAVQAGKFSNEKGAETLTEQLTEKGYSAVSLSKDDGYT YVIAGLASEKEVSQQLGQVLIDSDFEAWGGKELSLSIESDMTDSFKETAELAAKAILD EDITKASVEKIEKSLGETKASETGEKKAILQALKELEDPSAEAGWKAQQELLAVVK*" /label="spoIIB CDS" gene complement(2514409..2515407) /gene="spoIIB" /locus_tag="BSU_28060" /old_locus_tag="BSU28060" /label="spoIIB gene" promotor_-10 complement(2515454..2515473) /Source="Nicolas_upshift_promotors" /id="U2169" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.95104895104895" /psig="0.999000999001" /xcortree=443 /SigmaFactorBS="aacgttttttggacaaggcgacaaaagtctTGTTCTTTtttt ctttgccTGTGCTAAAGTGTGTAGCATgaaaagccgacaagaacggtcaagcaaatga a" /listShort="spoIIB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2515462) /Source="Nicolas_upshifts" /id="U2169" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.95104895104895" /psig="0.999000999001" /xcortree=443 /SigmaFactorBS="aacgttttttggacaaggcgacaaaagtctTGTTCTTTtttt ctttgccTGTGCTAAAGTGTGTAGCATgaaaagccgacaagaacggtcaagcaaatga a" /listShort="spoIIB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2515485..2515492) /Source="Nicolas_upshift_promotors" /id="U2169" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.95104895104895" /psig="0.999000999001" /xcortree=443 /SigmaFactorBS="aacgttttttggacaaggcgacaaaagtctTGTTCTTTtttt ctttgccTGTGCTAAAGTGTGTAGCATgaaaagccgacaagaacggtcaagcaaatga a" /listShort="spoIIB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2515530) /Source="Nicolas_upshifts" /id="D1436" /incds=0 /nref=1 /ntot=56 /MaxReadThrough="3.18314" /MaxDrop="2.89774" /score="11.209969" /energy="-7.6" /TU="U2170" /idTUdmin="U2170" /TUdmin="-440" /isTUend="FALSE" /label="downshifts" CDS complement(2515541..2516287) /gene="comC" /locus_tag="BSU_28070" /old_locus_tag="BSU28070" /EC_number="3.4.23.43" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:2553669, 9723928, 15849754, 16751195, 16850406, 16751195" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2553669, 9723928, 15849754, 16751195, 16850406, 16751195; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="membrane prepilin peptidase" /protein_id="NP_390685.2" /db_xref="EnsemblGenomes-Gn:BSU28070" /db_xref="EnsemblGenomes-Tr:CAB14767" /db_xref="GOA:P15378" /db_xref="InterPro:IPR000045" /db_xref="InterPro:IPR010627" /db_xref="SubtiList:BG10323" /db_xref="UniProtKB/Swiss-Prot:P15378" /translation="MLSILFIFGLILGSFYYTAGCRIPLHLSIIAPRSSCPFCRRTLT PAELIPILSFLFQKGKCKSCGHRISFMYPAAELVTACLFAAAGIRFGISLELFPAVVF ISLLIIVAVTDIHFMLIPNRILIFFLPFLAAARLISPLDSWYAGLLGAAAGFLFLAVI AAITHGGVGGGDIKLFAVIGFVLGVKMLAAAFFFSVLIGALYGAAAVLTGRLAKRQPL PFAPAIAAGSILAYLYGDSIISFYIKMALG*" /label="comC CDS" gene complement(2515541..2516287) /gene="comC" /locus_tag="BSU_28070" /old_locus_tag="BSU28070" /label="comC gene" promotor_-10 complement(2516315..2516334) /Source="Nicolas_upshift_promotors" /id="U2170" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.675324675324675" /psig="0.99000999000999" /xcortree=2963 /SigmaFactorBS="tttcatgtgtaaaattgaatattcccAATTGGAGctcaggat gtccatTTTGCTACAATCCATACCAGaactcaatgagtaaaggtgtgttgtctatgct a" /listShort="comC, spoIIB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2516322) /Source="Nicolas_upshifts" /id="U2170" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.675324675324675" /psig="0.99000999000999" /xcortree=2963 /SigmaFactorBS="tttcatgtgtaaaattgaatattcccAATTGGAGctcaggat gtccatTTTGCTACAATCCATACCAGaactcaatgagtaaaggtgtgttgtctatgct a" /listShort="comC, spoIIB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2516349..2516356) /Source="Nicolas_upshift_promotors" /id="U2170" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.675324675324675" /psig="0.99000999000999" /xcortree=2963 /SigmaFactorBS="tttcatgtgtaaaattgaatattcccAATTGGAGctcaggat gtccatTTTGCTACAATCCATACCAGaactcaatgagtaaaggtgtgttgtctatgct a" /listShort="comC, spoIIB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2516427..2517719) /gene="folC" /locus_tag="BSU_28080" /old_locus_tag="BSU28080" /EC_number="6.3.2.17" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2105929, 2985605, 3040739, 6994831, 9098041, 15705579, 22720735, 26443588; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="folyl-polyglutamate synthase" /protein_id="NP_390686.1" /db_xref="EnsemblGenomes-Gn:BSU28080" /db_xref="EnsemblGenomes-Tr:CAB14768" /db_xref="GOA:Q05865" /db_xref="InterPro:IPR001645" /db_xref="InterPro:IPR004101" /db_xref="InterPro:IPR013221" /db_xref="InterPro:IPR018109" /db_xref="InterPro:IPR036565" /db_xref="InterPro:IPR036615" /db_xref="SubtiList:BG10322" /db_xref="UniProtKB/Swiss-Prot:Q05865" /translation="MFTAYQDARSWIHGRLKFGVKPGLGRMKQLMARLGHPEKKIRAF HVAGTNGKGSTVAFIRSMLQEAGYTVGTFTSPYIITFNERISVNGIPISDEEWTALVN QMKPHVEALDQTEYGQPTEFEIMTACAFLYFAEFHKVDFVIFETGLGGRFDSTNVVEP LLTVITSIGHDHMNILGNTIEEIAGEKAGIIKEGIPIVTAVTQPEALQVIRHEAERHA APFQSLHDACVIFNEEALPAGEQFSFKTEEKCYEDIRTSLIGTHQRQNAALSILAAEW LNKENIAHISDEALRSGLVKAAWPGRLELVQEHPPVYLDGAHNEEGVEKLAETMKQRF ANSRISVVFSALKDKPYQNMIKRLETIAHAIHFASFDFPRASLAKDLYDASEISNKSW SEDPDDVIKFIESKKGSNEIVLITGSLYFISDIRKRLK*" /label="folC CDS" gene complement(2516427..2517719) /gene="folC" /locus_tag="BSU_28080" /old_locus_tag="BSU28080" /label="folC gene" downshifts complement(2516432) /Source="Nicolas_upshifts" /id="D1437" /incds=0 /nref=1 /ntot=121 /MaxReadThrough="1.66565" /MaxDrop="3.18428" /score="24.7086033" /energy="-14.3" /TU="NA" /idTUdmin="U2171" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2517720..2517778) /Source="Nicolas_S_feature" /locus_tag="new_2866605_2866663_c" /HighExp="S0, LBGexp, G150, MG 45, G135, G180, Gly, Oxctl, M0t45, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigEF" /TUlongPSig=1 /label="S1060" CDS complement(2517779..2520421) /gene="valS" /locus_tag="BSU_28090" /old_locus_tag="BSU28090" /EC_number="6.1.1.9" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9098041, 11114335, 25310979" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9098041, 11114335, 25310979; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="valyl-tRNA synthetase" /protein_id="NP_390687.2" /db_xref="EnsemblGenomes-Gn:BSU28090" /db_xref="EnsemblGenomes-Tr:CAB14769" /db_xref="GOA:Q05873" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR002300" /db_xref="InterPro:IPR002303" /db_xref="InterPro:IPR009008" /db_xref="InterPro:IPR009080" /db_xref="InterPro:IPR010978" /db_xref="InterPro:IPR013155" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR019499" /db_xref="InterPro:IPR033705" /db_xref="InterPro:IPR037118" /db_xref="SubtiList:BG10321" /db_xref="UniProtKB/Swiss-Prot:Q05873" /translation="METNEQTMPTKYDPAAVEKDRYDFWLKGKFFEAGSDQTKEPYSV VIPPPNVTGRLHLGHAWDTTLQDIVTRMKRMQGYDVLWLPGMDHAGIATQAKVEAKLR EEGKSRYDLGREKFLEETWKWKEEYADFIRSQWAKLGLGLDYSRERFTLDEGLSKAVR EVFVKLYEKGLIYRGEYIINWDPATKTALSDIEVIYKDVQGAFYHMSYPLADGSGSIE IATTRPETMLGDTAVAVHPEDERYKHLIGKTVILPIVNREIPIVGDDYVDMEFGSGAV KITPAHDPNDFELGNRHNLERILVMNEDGTMNENALQYQGMDRFECRKKLVKDLQEAG VLFKIEDHMHSVGHSERSGAVVEPYLSTQWFVRMQPLADAAIELQKKEEKVNFVPDRF EKTYLHWMENIRDWCISRQLWWGHRIPAWYHKETGELYVGLEAPEDSENWEQDTDVLD TWFSSALWPFSTMGWPDVTAEDFKRYYPTDVLVTGYDIIFFWVSRMIFQGIEFTGERP FKDVLIHGLIRDEQGRKMSKSLGNGVDPMDVIDKYGADSLRYFLATGSSPGQDLRFSY EKVESTWNFANKIWNASRFALMNMDGMTYDELDLSGEKSVADKWILTRLNETIEHVTQ LADRYEFGEVGRHLYNFIWDDFCDWYIEMAKLPLYGEDEAAKKTTRSILAYVLDQTMR LLHPFMPFLTEEIWQHLPHQGESITVSQWPAVVPEHTDTEAAADMKLLVELIRSVRNI RSEVNTPMSKQVELYIKTSTDEIASRLEANRSYVERFTNPSVLKIGTDIEAVDKAMTA VVSGAEVILPLEGLINIDEEIARLQKEFDKLTKEVERVQKKLGNEGFMKKAPAHVIDE EREKEKDYVAKRDAVQKRMAELKG*" /label="valS CDS" gene complement(2517779..2520421) /gene="valS" /locus_tag="BSU_28090" /old_locus_tag="BSU28090" /label="valS gene" S_feature complement(2520422..2520480) /Source="Nicolas_S_feature" /locus_tag="new_2869307_2869365_c" /HighExp="G150, G180, LBGexp, Oxctl, G135, dia0, HPh, Lbexp, Paraq, MG 60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-, SigEF" /TUshortPSig="1, 0.012, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1061" misc_RNA complement(2520481..2520703) /gene="tboV" /locus_tag="BSU_misc_RNA_44" /product="T-box riboswitch specific of valine tRNA" /experiment="publication(s) with functional evidences, PMID:1317842, 9098041, 12165569, 12547201" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1317842, 9098041, 12165569, 12547201; Product type n: RNA" /function="16.3: Control" /label="tboV RNA" gene complement(2520481..2520703) /gene="tboV" /locus_tag="BSU_misc_RNA_44" /label="tboV gene" downshifts complement(2520524) /Source="Nicolas_upshifts" /id="D1438" /incds=0 /nref=9 /ntot=27 /MaxReadThrough="6.76593" /MaxDrop="4.53149" /score="23.9897385" /energy="-20" /TU="U2171,U2173,U2176" /idTUdmin="U2176" /TUdmin="-726" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2520732..2520751) /Source="Nicolas_upshift_promotors" /id="U2171" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2387 /SigmaFactorBS="tctgtatagaaagcggtgtttttggaaaagatgATTGACgaa tcaaaaacactTTTACTATAATAAAGAACATaaataatgtatacaatgagctgataaa t" /listShort="NA, S1061, valS, S1060, folC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2520744) /Source="Nicolas_upshifts" /id="U2171" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2387 /SigmaFactorBS="tctgtatagaaagcggtgtttttggaaaagatgATTGACgaa tcaaaaacactTTTACTATAATAAAGAACATaaataatgtatacaatgagctgataaa t" /listShort="NA, S1061, valS, S1060, folC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2520746..2520854) /Source="Nicolas_S_feature" /locus_tag="new_2869631_2869739_c" /HighExp="S8, S6, S7, S5, B36, LoTm, S4, S3, BT, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigEF" /TUshortPSig="0.012, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1062" promotor_-35 complement(2520766..2520771) /Source="Nicolas_upshift_promotors" /id="U2171" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2387 /SigmaFactorBS="tctgtatagaaagcggtgtttttggaaaagatgATTGACgaa tcaaaaacactTTTACTATAATAAAGAACATaaataatgtatacaatgagctgataaa t" /listShort="NA, S1061, valS, S1060, folC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2520808..2520817 /Source="Nicolas_upshift_promotors" /id="U2172" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1272 /SigmaFactorBS="tcatcttttccaaaaacaccgctttctatacagatggGCAGG CACCTattgcccaagttTACATATGATGCTTGTAAATgcgtagaggaggatgcaccgt g" /listShort="yszA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2520830..2520849 /Source="Nicolas_upshift_promotors" /id="U2172" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1272 /SigmaFactorBS="tcatcttttccaaaaacaccgctttctatacagatggGCAGG CACCTattgcccaagttTACATATGATGCTTGTAAATgcgtagaggaggatgcaccgt g" /listShort="yszA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2520831 /Source="Nicolas_upshifts" /id="U2172" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1272 /SigmaFactorBS="tcatcttttccaaaaacaccgctttctatacagatggGCAGG CACCTattgcccaagttTACATATGATGCTTGTAAATgcgtagaggaggatgcaccgt g" /listShort="yszA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2520847..2520861) /Source="Nicolas_upshift_promotors" /id="U2173" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.98001998001998" /psig="0.011988011988012" /xcortree=1270 /SigmaFactorBS="gccttacccatggcggcagcgaataagagctgaaacgtttcT TCACggtgcatCCTCCTCTACGCATTtacaagcatcatatgtaaacttgggcaatagg t" /listShort="S1062, NA, S1061, valS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2520854) /Source="Nicolas_upshifts" /id="U2173" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.98001998001998" /psig="0.011988011988012" /xcortree=1270 /SigmaFactorBS="gccttacccatggcggcagcgaataagagctgaaacgtttcT TCACggtgcatCCTCCTCTACGCATTtacaagcatcatatgtaaacttgggcaatagg t" /listShort="S1062, NA, S1061, valS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2520869..2520873) /Source="Nicolas_upshift_promotors" /id="U2173" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.98001998001998" /psig="0.011988011988012" /xcortree=1270 /SigmaFactorBS="gccttacccatggcggcagcgaataagagctgaaacgtttcT TCACggtgcatCCTCCTCTACGCATTtacaagcatcatatgtaaacttgggcaatagg t" /listShort="S1062, NA, S1061, valS" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2520869..2521060 /gene="yszA" /locus_tag="BSU_28099" /old_locus_tag="BSU28099" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097770.1" /db_xref="EnsemblGenomes-Gn:BSU28099" /db_xref="EnsemblGenomes-Tr:CAX52676" /db_xref="GOA:C0H465" /db_xref="UniProtKB/Swiss-Prot:C0H465" /translation="MKKRFSSYSLPPWVRQIRLVSAQVIIPITIFQGIRTIFFPTTFD VLLLAILIFLACALHLEWI*" /label="yszA CDS" gene 2520869..2521060 /gene="yszA" /locus_tag="BSU_28099" /old_locus_tag="BSU28099" /label="yszA gene" CDS complement(2521079..2522104) /gene="cotN" /locus_tag="BSU_28100" /old_locus_tag="BSU28100" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16371471, 16390444, 22091839" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16371471, 16390444, 22091839; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat protein" /protein_id="NP_390688.1" /db_xref="EnsemblGenomes-Gn:BSU28100" /db_xref="EnsemblGenomes-Tr:CAB14770" /db_xref="InterPro:IPR011009" /db_xref="InterPro:IPR014253" /db_xref="SubtiList:BG10347" /db_xref="UniProtKB/Swiss-Prot:P37964" /translation="MEDTQSVLQEYGLTAQFIEPVSPLVWKVYTDYGIFALKKLKEGR GKHFTDHMVAIEEKGFRSFVPVYRTNSGEFFSAGIQYGDIYYLMPWLQFDQEEERDQK HAYLFRETARLHERTAQELKVRRDEIERYYGQTKKKWEQDKIFYEQFVDRAEKEWYLS PFELQAITYFSETISAVNFALERLEDWYESAKEKDVSRVVMNHGSLSIHHFLYNDAGT GYFTNFERASVGPPQNDLLGFYTKMFRGFPKACPECVEWFYGYTKSFPLREAEVSLFL SYMAYPAAMYKVLNGYQTGKRQHEKEECTQLLKAYWQMKNIEPFVMKIHQIEQEKKFQ AENESTS*" /label="cotN CDS" gene complement(2521079..2522104) /gene="cotN" /locus_tag="BSU_28100" /old_locus_tag="BSU28100" /label="cotN gene" downshifts complement(2521109) /Source="Nicolas_upshifts" /id="D1439" /incds=0 /nref=23 /ntot=70 /MaxReadThrough="4.44965" /MaxDrop="6.68961" /score="-7.46388093" /energy="-12.1" /TU="U2176" /idTUdmin="U2176" /TUdmin="-1311" /isTUend="FALSE" /label="downshifts" CDS complement(2522137..2523864) /gene="spoVID" /locus_tag="BSU_28110" /old_locus_tag="BSU28110" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:11325931, 16371471, 16950916, 22773792, 23178679" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11325931, 16371471, 16950916, 22773792, 23178679; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="morphogenetic spore protein (stage VI sporulation)" /protein_id="NP_390689.1" /db_xref="EnsemblGenomes-Gn:BSU28110" /db_xref="EnsemblGenomes-Tr:CAB14771" /db_xref="GOA:P37963" /db_xref="InterPro:IPR018392" /db_xref="InterPro:IPR036779" /db_xref="SubtiList:BG10346" /db_xref="UniProtKB/Swiss-Prot:P37963" /translation="MPQNHRLQFSVEESICFQKGQEVSELLSISLDPDIRVQEVNDYV SIIGSLELTGEYNIDQNKHTEEIYTDKRFVEQVRKREDGSAELTHCFPVDITIPKNKV SHLQDVFVFIDAFDYQLTDSRILTIQADLAIEGLLDDTQDKEPEIPLYEAPAAFREEE LSEPPAHSVVEEPGASSAEEAVLQHEPPAEPPELFISKAGLREELETEKAESEPPESV ASEPEAREDVKEEEESEELAVPETEVRAESETEESEPEPDPSEIEIQEIVKAKKETAE PAAAIADVREEADSPAETELREHVGAEESPALEAELHSETVIAKEKEETTVSPNHEYA LRQEAQNEEAAQSDQADPALCQEEAEPDEALESVSEAALSIEDSRETASAVYMENDNA DLHFHFNQKTSSEEASQEELPEPAYRTFLPEQEEEDSFYSAPKLLEEEEQEEESFEIE VRKTPSAEEPKEETPFQSFQLPESSETERKETDAVPRVAPAAETKEPQTKESDNSLYL TKLFTKEADEFSRMKICIVQQEDTIERLCERYEITSQQLIRMNSLALDDELKAGQILY IPQYKNSHA*" /label="spoVID CDS" gene complement(2522137..2523864) /gene="spoVID" /locus_tag="BSU_28110" /old_locus_tag="BSU28110" /label="spoVID gene" promotor_-35 2523466..2523469 /Source="Nicolas_upshift_promotors" /id="U2174" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.456543456543457" /psig="0.684315684315684" /xcortree=691 /SigmaFactorBS="ggctctttgtcttgcgtatcgtccaaaagcccttcGATCgct aaatcagcttgaATTGTTAAAATGCGCGAATCcgtcaattgatagtcaaatgcgtcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2523485..2523504 /Source="Nicolas_upshift_promotors" /id="U2174" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.456543456543457" /psig="0.684315684315684" /xcortree=691 /SigmaFactorBS="ggctctttgtcttgcgtatcgtccaaaagcccttcGATCgct aaatcagcttgaATTGTTAAAATGCGCGAATCcgtcaattgatagtcaaatgcgtcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2523491 /Source="Nicolas_upshifts" /id="U2174" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.456543456543457" /psig="0.684315684315684" /xcortree=691 /SigmaFactorBS="ggctctttgtcttgcgtatcgtccaaaagcccttcGATCgct aaatcagcttgaATTGTTAAAATGCGCGAATCcgtcaattgatagtcaaatgcgtcaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2523860..2523864 /Source="Nicolas_upshift_promotors" /id="U2175" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=699 /SigmaFactorBS="tcttctacagaaaattgcaatcgatgattttgcGGCAAgttc atatCCTCCTTTCATCTAAtccttaaaattagatgtcactaaaggtgtatgtatgaac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2523873..2523887 /Source="Nicolas_upshift_promotors" /id="U2175" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=699 /SigmaFactorBS="tcttctacagaaaattgcaatcgatgattttgcGGCAAgttc atatCCTCCTTTCATCTAAtccttaaaattagatgtcactaaaggtgtatgtatgaac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2523887 /Source="Nicolas_upshifts" /id="U2175" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=699 /SigmaFactorBS="tcttctacagaaaattgcaatcgatgattttgcGGCAAgttc atatCCTCCTTTCATCTAAtccttaaaattagatgtcactaaaggtgtatgtatgaac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2523902..2523920) /Source="Nicolas_upshift_promotors" /id="U2176" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1091 /SigmaFactorBS="caaggactccttgtgccggttttttcgtgctctcccaCTCAT AttttctccagttcatACATACACCTTTAGTGACAtctaattttaaggattagatgaa a" /listShort="spoVID, ysxE, S1062, NA, S1061, valS" /listLong="S1060, folC" /label="promotor_-10" upshifts complement(2523918) /Source="Nicolas_upshifts" /id="U2176" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1091 /SigmaFactorBS="caaggactccttgtgccggttttttcgtgctctcccaCTCAT AttttctccagttcatACATACACCTTTAGTGACAtctaattttaaggattagatgaa a" /listShort="spoVID, ysxE, S1062, NA, S1061, valS" /listLong="S1060, folC" /label="upshifts" promotor_-35 complement(2523936..2523941) /Source="Nicolas_upshift_promotors" /id="U2176" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1091 /SigmaFactorBS="caaggactccttgtgccggttttttcgtgctctcccaCTCAT AttttctccagttcatACATACACCTTTAGTGACAtctaattttaaggattagatgaa a" /listShort="spoVID, ysxE, S1062, NA, S1061, valS" /listLong="S1060, folC" /label="promotor_-35" CDS complement(2523995..2525287) /gene="hemL" /locus_tag="BSU_28120" /old_locus_tag="BSU28120" /EC_number="5.4.3.8" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1672867, 12029044, 15802251, 16682782, 20946885, 27303897" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1672867, 12029044, 15802251, 16682782, 20946885, 27303897; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="glutamate-1-semialdehyde 2,1-aminomutase" /protein_id="NP_390690.1" /db_xref="EnsemblGenomes-Gn:BSU28120" /db_xref="EnsemblGenomes-Tr:CAB14772" /db_xref="GOA:P30949" /db_xref="InterPro:IPR004639" /db_xref="InterPro:IPR005814" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="PDB:3BS8" /db_xref="SubtiList:BG10345" /db_xref="UniProtKB/Swiss-Prot:P30949" /translation="MRSYEKSKTAFKEAQKLMPGGVNSPVRAFKSVDMDPIFMERGKG SKIFDIDGNEYIDYVLSWGPLILGHTNDRVVESLKKVAEYGTSFGAPTEVENELAKLV IDRVPSVEIVRMVSSGTEATMSALRLARGYTGRNKILKFEGCYHGHGDSLLIKAGSGV ATLGLPDSPGVPEGIAKNTITVPYNDLESVKLAFQQFGEDIAGVIVEPVAGNMGVVPP QEGFLQGLRDITEQYGSLLIFDEVMTGFRVDYNCAQGYFGVTPDLTCLGKVIGGGLPV GAYGGKAEIMEQIAPSGPIYQAGTLSGNPLAMTAGLETLKQLTPESYKNFIKKGDRLE EGISKTAGAHGIPHTFNRAGSMIGFFFTNEPVINYETAKSSDLKLFASYYKGMANEGV FLPPSQFEGLFLSTAHTDEDIENTIQAAEKVFAEISRR*" /label="hemL CDS" gene complement(2523995..2525287) /gene="hemL" /locus_tag="BSU_28120" /old_locus_tag="BSU28120" /label="hemL gene" downshifts complement(2524012) /Source="Nicolas_upshifts" /id="D1440" /incds=0 /nref=144 /ntot=397 /MaxReadThrough="3.40168" /MaxDrop="7.29251" /score="3.77738386" /energy="-10.6" /TU="NA" /idTUdmin="U2177" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" CDS complement(2525317..2526291) /gene="hemB" /locus_tag="BSU_28130" /old_locus_tag="BSU28130" /EC_number="4.2.1.24" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2110138, 12029044, 15802251, 20823524, 24598743" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2110138, 12029044, 15802251, 20823524, 24598743; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="delta-aminolevulinic acid dehydratase (porphobilinogen synthase)" /protein_id="NP_390691.1" /db_xref="EnsemblGenomes-Gn:BSU28130" /db_xref="EnsemblGenomes-Tr:CAB14773" /db_xref="GOA:P30950" /db_xref="InterPro:IPR001731" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR030656" /db_xref="SubtiList:BG10344" /db_xref="UniProtKB/Swiss-Prot:P30950" /translation="MSQSFNRHRRLRTSKAMREMVKETRLHPSDFIYPIFVVEGLEGK KAVPSMPDVHHVSLDLLKDEVAELVKLGIQSVIVFGIPEEKDDCGTQAYHDHGIVQKA ITEIKEHFPEMVVVADTCLCEYTDHGHCGLVKDGVILNDESLELLAQTAVSQAKAGAD IIAPSNMMDGFVTVIREALDKEGFVNIPIMSYAVKYSSEFYGPFRDAANSTPQFGDRK TYQMDPANRMEALREAQSDVEEGADFLIVKPSLSYMDIMRDVKNEFTLPLVAYNVSGE YSMVKAAAQNGWIKEKEIVLEILTSMKRAGADLIITYHAKDAAKWLAE*" /label="hemB CDS" gene complement(2525317..2526291) /gene="hemB" /locus_tag="BSU_28130" /old_locus_tag="BSU28130" /label="hemB gene" CDS complement(2526288..2527076) /gene="hemD" /locus_tag="BSU_28140" /old_locus_tag="BSU28140" /EC_number="4.2.1.75" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1672867, 2110138, 7628476, 12029044, 12196144, 15802251" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1672867, 2110138, 7628476, 12029044, 12196144, 15802251; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="uroporphyrinogen III cosynthase" /protein_id="NP_390692.1" /db_xref="EnsemblGenomes-Gn:BSU28140" /db_xref="EnsemblGenomes-Tr:CAB14774" /db_xref="GOA:P21248" /db_xref="InterPro:IPR003754" /db_xref="InterPro:IPR036108" /db_xref="SubtiList:BG10343" /db_xref="UniProtKB/Swiss-Prot:P21248" /translation="MENDFPLKGKTVLVTRNKAQAASFQQKVEALGGKAVLTSLITFR RALPNDVAEQVREDLAAPGWLVFTSVNGADFFFSYLKENQLILPAHKKIAAVGEKTAR RLKMHNVSVDVMPQEYIAEQLADALKQHAEPGETITVMKGNLSRDVIKQELVPLGFEV KEWVLYETIPDEEGIEALKDAAGQYSFDYVTFTSSSTVHTFMHVLGEELKKWKANGTA CISIGPLTNDALLTYGITSHTPDTFTIDGMLELMCSMSREEERI*" /label="hemD CDS" gene complement(2526288..2527076) /gene="hemD" /locus_tag="BSU_28140" /old_locus_tag="BSU28140" /label="hemD gene" CDS complement(2527066..2528010) /gene="hemC" /locus_tag="BSU_28150" /old_locus_tag="BSU28150" /EC_number="2.5.1.61" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2110138, 9058548, 12029044, 15802251, 23908040, 24598743" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2110138, 9058548, 12029044, 15802251, 23908040, 24598743; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="porphobilinogen deaminase (hydroxymethylbilane synthase)" /protein_id="NP_390693.1" /db_xref="EnsemblGenomes-Gn:BSU28150" /db_xref="EnsemblGenomes-Tr:CAB14775" /db_xref="GOA:P16616" /db_xref="InterPro:IPR000860" /db_xref="InterPro:IPR022417" /db_xref="InterPro:IPR022418" /db_xref="InterPro:IPR022419" /db_xref="InterPro:IPR036803" /db_xref="SubtiList:BG10342" /db_xref="UniProtKB/Swiss-Prot:P16616" /translation="MMRTIKVGSRRSKLAMTQTKWVIQKLKEINPSFAFEIKEIVTKG DRIVDVTLSKVGGKGLFVKEIEQALLNEEIDMAVHSMKDMPAVLPEGLVIGCIPERED PRDALISKNRVKLSEMKKGAVIGTSSLRRSAQLLIERPDLTIKWIRGNIDTRLQKLET EDYDAIILAAAGLSRMGWKQDVVTEFLEPERCLPAVGQGALAIECRESDEELLALFSQ FTDEYTKRTVLAERAFLNAMEGGCQVPIAGYSVLNGQDEIEMTGLVASPDGKIIFKET VTGNDPEEVGKRCAALMADKGAKDLIDRVKRELDEDGK*" /label="hemC CDS" gene complement(2527066..2528010) /gene="hemC" /locus_tag="BSU_28150" /old_locus_tag="BSU28150" /label="hemC gene" CDS complement(2528043..2528873) /gene="hemX" /locus_tag="BSU_28160" /old_locus_tag="BSU28160" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8012594, 12029044, 15802251, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8012594, 12029044, 15802251, 15849754, 16850406; Product type f: factor" /codon_start=1 /transl_table=11 /product="negative effector of the concentration of glutamyl-tRNA reductase HemA" /protein_id="NP_390694.2" /db_xref="EnsemblGenomes-Gn:BSU28160" /db_xref="EnsemblGenomes-Tr:CAB14776" /db_xref="GOA:P16645" /db_xref="InterPro:IPR002541" /db_xref="SubtiList:BG10341" /db_xref="UniProtKB/Swiss-Prot:P16645" /translation="MIDTAMARLNEGTIVIYALSVLFYFIDFLQHNRKAGKMAFWLLS IVWTLQTVYLAYFMWVTGRFPVLNVTEALYFYAWVLVTLSLVLTKLLRVDFIVFFTNV IGFSMIAIHTFSPTEQQSAAFSGQLVSELLVIHITMAILSYGAFSLSFVFSVLYMFQY HLLKKKKWGKWLLRIEDLSKLDYMAYVLNVIGVPMLLLSLILGVIWAYVSLETLYWFD AKVLGSFVVLLLYSYYLYIRLIKELQGKVAALWNTACFLVLMINYFLLGSLSQFHWFS *" /label="hemX CDS" gene complement(2528043..2528873) /gene="hemX" /locus_tag="BSU_28160" /old_locus_tag="BSU28160" /label="hemX gene" CDS complement(2528881..2530248) /gene="hemA" /locus_tag="BSU_28170" /old_locus_tag="BSU28170" /EC_number="1.2.1.70" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1536660, 15802251, 1672867, 2490162, 12029044" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1536660, 15802251, 1672867, 2490162, 12029044; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamyl-tRNA reductase" /protein_id="NP_390695.1" /db_xref="EnsemblGenomes-Gn:BSU28170" /db_xref="EnsemblGenomes-Tr:CAB14777" /db_xref="GOA:P16618" /db_xref="InterPro:IPR000343" /db_xref="InterPro:IPR006151" /db_xref="InterPro:IPR015895" /db_xref="InterPro:IPR015896" /db_xref="InterPro:IPR018214" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR036343" /db_xref="InterPro:IPR036453" /db_xref="SubtiList:BG10340" /db_xref="UniProtKB/Swiss-Prot:P16618" /translation="MHILVVGVDYKSAPIEIREKVSFQPNELAEAMVQLKEEKSILEN IIVSTCNRTEIYAVVDQLHTGRYYIKKFLADWFQLSKEELSPFLTFYESDAAVEHLFR VACGLDSMVIGETQILGQVRDSFKTAQQEKTIGTIFNELFKQAVTVGKRTHAETDIGS NAVSVSYAAVELAKKIFGNLSSKHILILGAGKMGELAAENLHGQGIGKVTVINRTYLK AKELADRFSGEARSLNQLESALAEADILISSTGASEFVVSKEMMENANKLRKGRPLFM VDIAVPRDLDPALNDLEGVFLYDIDDLEGIVEANMKERRETAEKVELLIEETIVEFKQ WMNTLGVVPVISALREKALAIQSETMDSIERKLPHLSTREKKLLNKHTKSIINQMLRD PILKVKELAADADSEEKLALFMQIFDIEEAAGRQMMKTVESSQKVHSFKKAESKAGFS PLVSE*" /label="hemA CDS" gene complement(2528881..2530248) /gene="hemA" /locus_tag="BSU_28170" /old_locus_tag="BSU28170" /label="hemA gene" misc_feature complement(2530312..2530331) /Source="Nicolas_upshift_promotors" /id="U2177" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.932067932067932" /psig="0.999000999001" /xcortree=1604 /SigmaFactorBS="atatagcataagaattttaaaatctgttcacattttgtgaaa gaaacTATGTTATAATTATTATAAAtaatgagttctatgttagaatgattataaatta a" /listShort="hemA, hemX, hemC, hemD, hemB, hemL" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2530318) /Source="Nicolas_upshifts" /id="U2177" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.932067932067932" /psig="0.999000999001" /xcortree=1604 /SigmaFactorBS="atatagcataagaattttaaaatctgttcacattttgtgaaa gaaacTATGTTATAATTATTATAAAtaatgagttctatgttagaatgattataaatta a" /listShort="hemA, hemX, hemC, hemD, hemB, hemL" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2530320..2530409) /Source="Nicolas_S_feature" /locus_tag="new_2879205_2879294_c" /HighExp="dia15, Salt, dia5, Etha, Paraq, H2O2, Diami, Heat, LoTm, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB, SigGF" /TUshortPSig="0.997, 1, 0.948" /TUlongSig="NA" /TUlongPSig="NA" /label="S1063" misc_feature 2530369..2530388 /Source="Nicolas_upshift_promotors" /id="U2178" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.94105894105894" /psig=1 /xcortree=2409 /SigmaFactorBS="aataattataacatagtttctttcacaaaatgtgaacagatt ttaaaattctTATGCTATATTAGAAAAAGCttcagggaaaagaagcattcctattgac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2530377 /Source="Nicolas_upshifts" /id="U2178" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.94105894105894" /psig=1 /xcortree=2409 /SigmaFactorBS="aataattataacatagtttctttcacaaaatgtgaacagatt ttaaaattctTATGCTATATTAGAAAAAGCttcagggaaaagaagcattcctattgac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2530406..2530425) /Source="Nicolas_upshift_promotors" /id="U2179" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.693306693306693" /psig="0.997002997002997" /xcortree=1856 /SigmaFactorBS="ccttcttgttttttagagctgatgtGTAGTAAATttctgctg ttTTTGGTATTGTCAATAGGAAtgcttcttttccctgaagctttttctaatatagcat a" /listShort="S1063, hemA, hemX, hemC, hemD, hemB, hemL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2530409) /Source="Nicolas_upshifts" /id="U2179" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.693306693306693" /psig="0.997002997002997" /xcortree=1856 /SigmaFactorBS="ccttcttgttttttagagctgatgtGTAGTAAATttctgctg ttTTTGGTATTGTCAATAGGAAtgcttcttttccctgaagctttttctaatatagcat a" /listShort="S1063, hemA, hemX, hemC, hemD, hemB, hemL" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2530411..2530827) /Source="Nicolas_S_feature" /locus_tag="new_2879296_2879712_c" /HighExp="Etha, S5, Gly, S7, S4, S8, S6, H2O2, dia15, G135" /AntisenseName="ysxD" /AntisenseCor="-1.16761021676615E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigGF" /TUshortPSig="1, 0.948" /TUlongSig="NA" /TUlongPSig="NA" /label="S1064" promotor_-35 complement(2530436..2530444) /Source="Nicolas_upshift_promotors" /id="U2179" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.693306693306693" /psig="0.997002997002997" /xcortree=1856 /SigmaFactorBS="ccttcttgttttttagagctgatgtGTAGTAAATttctgctg ttTTTGGTATTGTCAATAGGAAtgcttcttttccctgaagctttttctaatatagcat a" /listShort="S1063, hemA, hemX, hemC, hemD, hemB, hemL" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2530478..2530975 /gene="ysxD" /locus_tag="BSU_28180" /old_locus_tag="BSU28180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390696.2" /db_xref="EnsemblGenomes-Gn:BSU28180" /db_xref="EnsemblGenomes-Tr:CAB14778" /db_xref="GOA:P40736" /db_xref="SubtiList:BG11068" /db_xref="UniProtKB/Swiss-Prot:P40736" /translation="MKQKSILFPCLLLAASVYAWLESGQAELFSGQDQWPVLLMLLGA AFVYQGKKEAVTPHFFIGLLLFGIGLHFFAKPKWVWWPDDFEMLLFMIGFSLLVSTVQ KKEYVYEAVSMICFSLFLYFFKQIMAWLESAHIPTALLKEYWPFVFIGISLLLLLIKR KKSIR*" /label="ysxD CDS" gene 2530478..2530975 /gene="ysxD" /locus_tag="BSU_28180" /old_locus_tag="BSU28180" /label="ysxD gene" promotor_-10 complement(2530811..2530829) /Source="Nicolas_upshift_promotors" /id="U2180" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=747 /SigmaFactorBS="gttggaatatgcgcagactcaagccatgccataattTGTTTG AaaaagtacaaaaacaGGGAAAAACAAATCATCGAcacagcttcatatacatattctt t" /listShort="S1064, S1063, hemA, hemX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2530827) /Source="Nicolas_upshifts" /id="U2180" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=747 /SigmaFactorBS="gttggaatatgcgcagactcaagccatgccataattTGTTTG AaaaagtacaaaaacaGGGAAAAACAAATCATCGAcacagcttcatatacatattctt t" /listShort="S1064, S1063, hemA, hemX" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2530829..2530959) /Source="Nicolas_S_feature" /locus_tag="new_2879714_2879844_c" /HighExp="S5, S4, S8, S6, H2O2, S7, Etha, dia15, Diami, G180" /AntisenseName="ysxD" /AntisenseCor="-1.18079537254433E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.948" /TUlongSig="NA" /TUlongPSig="NA" /label="S1065" promotor_-35 complement(2530845..2530851) /Source="Nicolas_upshift_promotors" /id="U2180" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=747 /SigmaFactorBS="gttggaatatgcgcagactcaagccatgccataattTGTTTG AaaaagtacaaaaacaGGGAAAAACAAATCATCGAcacagcttcatatacatattctt t" /listShort="S1064, S1063, hemA, hemX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2530939..2530950) /Source="Nicolas_upshift_promotors" /id="U2181" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1211 /SigmaFactorBS="tcaaaaaaatgataaaccggtagaggatcctctaccggtttt atttatCGTATAGatttttttcgttttATCAATAATAACaataaactgattccaataa a" /listShort="S1065, S1064, S1063" /listLong="hemA" /label="promotor_-10" upshifts complement(2530959) /Source="Nicolas_upshifts" /id="U2181" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1211 /SigmaFactorBS="tcaaaaaaatgataaaccggtagaggatcctctaccggtttt atttatCGTATAGatttttttcgttttATCAATAATAACaataaactgattccaataa a" /listShort="S1065, S1064, S1063" /listLong="hemA" /label="upshifts" promotor_-35 complement(2530965..2530971) /Source="Nicolas_upshift_promotors" /id="U2181" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.948051948051948" /psig="0.948051948051948" /xcortree=1211 /SigmaFactorBS="tcaaaaaaatgataaaccggtagaggatcctctaccggtttt atttatCGTATAGatttttttcgttttATCAATAATAACaataaactgattccaataa a" /listShort="S1065, S1064, S1063" /listLong="hemA" /label="promotor_-35" CDS complement(2530997..2531584) /gene="engB" /locus_tag="BSU_28190" /old_locus_tag="BSU28190" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 16997968, 17981968, 21360172, 21636901, 25771857, 26103561, 27484475" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16997968, 17981968, 21360172, 21636901, 25771857, 26103561, 27484475; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="GTPase involved in ribosome 50S subunit assembly(maturation of the central 50S protuberance)" /protein_id="NP_390697.1" /db_xref="EnsemblGenomes-Gn:BSU28190" /db_xref="EnsemblGenomes-Tr:CAB14779" /db_xref="GOA:P38424" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR019987" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030393" /db_xref="PDB:1SUL" /db_xref="PDB:1SVI" /db_xref="PDB:1SVW" /db_xref="SubtiList:BG10339" /db_xref="UniProtKB/Swiss-Prot:P38424" /translation="MKVTKSEIVISAVKPEQYPEGGLPEIALAGRSNVGKSSFINSLI NRKNLARTSSKPGKTQTLNFYIINDELHFVDVPGYGFAKVSKSEREAWGRMIETYITT REELKAVVQIVDLRHAPSNDDVQMYEFLKYYGIPVIVIATKADKIPKGKWDKHAKVVR QTLNIDPEDELILFSSETKKGKDEAWGAIKKMINR*" /label="engB CDS" gene complement(2530997..2531584) /gene="engB" /locus_tag="BSU_28190" /old_locus_tag="BSU28190" /label="engB gene" downshifts complement(2531025) /Source="Nicolas_upshifts" /id="D1441" /incds=0 /nref=78 /ntot=212 /MaxReadThrough="4.03888" /MaxDrop="6.16077" /score="19.8235959" /energy="-13.4" /TU="NA" /idTUdmin="U2182" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2531581..2533905) /gene="lonA" /locus_tag="BSU_28200" /old_locus_tag="BSU28200" /EC_number="3.4.21.53" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10411757, 11325926, 15987505, 18689473, 20600124, 21546913, 25538299, 26677871" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10411757, 11325926, 15987505, 18689473, 20600124, 21546913, 25538299, 26677871; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="class III heat-shock ATP-dependent LonA protease" /protein_id="NP_390698.1" /db_xref="EnsemblGenomes-Gn:BSU28200" /db_xref="EnsemblGenomes-Tr:CAB14780" /db_xref="GOA:P37945" /db_xref="InterPro:IPR003111" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR003959" /db_xref="InterPro:IPR004815" /db_xref="InterPro:IPR008268" /db_xref="InterPro:IPR008269" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR027065" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR027543" /db_xref="PDB:1X37" /db_xref="PDB:3M65" /db_xref="PDB:3M6A" /db_xref="SubtiList:BG10338" /db_xref="UniProtKB/Swiss-Prot:P37945" /translation="MAEELKRSIPLLPLRGLLVYPTMVLHLDVGRDKSVQALEQAMMH DHMIFLATQQDISIDEPGEDEIFTVGTYTKIKQMLKLPNGTIRVLVEGLKRAHIVKYN EHEDYTSVDIQLIHEDDSKDTEDEALMRTLLDHFDQYIKISKKISAETYAAVTDIEEP GRMADIVASHLPLKLKDKQDILETADVKDRLNKVIDFINNEKEVLEIEKKIGQRVKRS MERTQKEYYLREQMKAIQKELGDKEGKTGEVQTLTEKIEEAGMPDHVKETALKELNRY EKIPSSSAESSVIRNYIDWLVALPWTDETDDKLDLKEAGRLLDEEHHGLEKVKERILE YLAVQKLTKSLKGPILCLAGPPGVGKTSLAKSIAKSLGRKFVRISLGGVRDESEIRGH RRTYVGAMPGRIIQGMKKAGKLNPVFLLDEIDKMSSDFRGDPSSAMLEVLDPEQNSSF SDHYIEETFDLSKVLFIATANNLATIPGPLRDRMEIINIAGYTEIEKLEIVKDHLLPK QIKEHGLKKSNLQLRDQAILDIIRYYTREAGVRSLERQLAAICRKAAKAIVAEERKRI TVTEKNLQDFIGKRIFRYGQAETEDQVGVVTGLAYTTVGGDTLSIEVSLSPGKGKLIL TGKLGDVMRESAQAAFSYVRSKTEELGIEPDFHEKYDIHIHVPEGAVPKDGPSAGITM ATALVSALTGRAVSREVGMTGEITLRGRVLPIGGLKEKALGAHRAGLTTIIAPKDNEK DIEDIPESVREGLTFILASHLDEVLEHALVGEKK*" /label="lonA CDS" gene complement(2531581..2533905) /gene="lonA" /locus_tag="BSU_28200" /old_locus_tag="BSU28200" /label="lonA gene" S_feature complement(2533906..2534017) /Source="Nicolas_S_feature" /locus_tag="new_2882791_2882902_c" /HighExp="Etha, dia15, LBGtran, dia5, Diami, H2O2, LBGexp, Lbexp, LoTm, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.967" /TUlongSig="NA" /TUlongPSig="NA" /label="S1066" promotor_-10 complement(2534002..2534021) /Source="Nicolas_upshift_promotors" /id="U2182" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.646353646353646" /psig="0.967032967032967" /xcortree=2001 /SigmaFactorBS="ttgataatagggtttttttcatgaaggacatctttTCCTTTT TcatatcagaaagaAAGGGTATACTACGAGGAGActgttttatagaaaatggaaccat g" /listShort="S1066, lonA, ysxC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2534017) /Source="Nicolas_upshifts" /id="U2182" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.646353646353646" /psig="0.967032967032967" /xcortree=2001 /SigmaFactorBS="ttgataatagggtttttttcatgaaggacatctttTCCTTTT TcatatcagaaagaAAGGGTATACTACGAGGAGActgttttatagaaaatggaaccat g" /listShort="S1066, lonA, ysxC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2534035..2534042) /Source="Nicolas_upshift_promotors" /id="U2182" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.646353646353646" /psig="0.967032967032967" /xcortree=2001 /SigmaFactorBS="ttgataatagggtttttttcatgaaggacatctttTCCTTTT TcatatcagaaagaAAGGGTATACTACGAGGAGActgttttatagaaaatggaaccat g" /listShort="S1066, lonA, ysxC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2534086..2535744) /gene="lonB" /locus_tag="BSU_28210" /old_locus_tag="BSU28210" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10411757, 11325926, 18689473, 26428922" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10411757, 11325926, 18689473, 26428922; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore-specific ATP-dependent protease LonB" /protein_id="NP_390699.1" /db_xref="EnsemblGenomes-Gn:BSU28210" /db_xref="EnsemblGenomes-Tr:CAB14781" /db_xref="GOA:P42425" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR003959" /db_xref="InterPro:IPR008268" /db_xref="InterPro:IPR008269" /db_xref="InterPro:IPR014251" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR027065" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11077" /db_xref="UniProtKB/Swiss-Prot:P42425" /translation="MSWTGIALFIQLFFGIIIGLYFWNLLKNQRTQKVTIDKESKKEM EQLRKMRAISLSEPLSEKVRPKSFKDIVGQEDGIKALKAALCGPNPQHVIVYGPPGVG KTAAARLVLEEAKKHKQSPFKEQAVFVELDATTARFDERGIADPLIGSVHDPIYQGAG AMGQAGIPQPKQGAVTHAHGGVLFIDEIGELHPIQMNKMLKVLEDRKVFLDSAYYSEE NTQIPNHIHDIFQNGLPADFRLIGATTRMPNEIPPAIRSRCLEVFFRELEKDELKTVA KTAADKIEKNISEEGLDLLTSYTRNGREAVNMIQIAAGMAVTENRKDITIEDIEWVIH SSQLTPKHEQKIGVEPQVGIVNGLAVYGPNSGSLLEIEVSVTAAQDKGSINITGIAEE ESIGSQSKSIRRKSMAKGSVENVLTVLRTMGMKPSDYDIHINFPGGIPIDGPSAGIAM AAGIFSAIHKIPIDNTVAMTGEISLNGLVKPIGGVIPKIKAAKQSGAKKVIIPYENQQ AILKQIDGIEIIAVKTFQEVLDEILVNPPTEQKPFHIEINKESV*" /label="lonB CDS" gene complement(2534086..2535744) /gene="lonB" /locus_tag="BSU_28210" /old_locus_tag="BSU28210" /label="lonB gene" downshifts complement(2534105) /Source="Nicolas_upshifts" /id="D1442" /incds=0 /nref=24 /ntot=42 /MaxReadThrough="2.32825" /MaxDrop="4.82102" /score="7.30551887" /energy="-7.1" /TU="NA" /idTUdmin="U2183" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2535788..2535806) /Source="Nicolas_upshift_promotors" /id="U2183" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.66933066933067" /psig="0.66933066933067" /xcortree=1167 /SigmaFactorBS="aggtttttttgcatgcaactcttccggaaaaaCGTTTAttcc cgtcttctatgGGAGATACTAGCAATCAGAggaatgaattggatacataaattgtttt t" /listShort="lonB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2535799) /Source="Nicolas_upshifts" /id="U2183" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.66933066933067" /psig="0.66933066933067" /xcortree=1167 /SigmaFactorBS="aggtttttttgcatgcaactcttccggaaaaaCGTTTAttcc cgtcttctatgGGAGATACTAGCAATCAGAggaatgaattggatacataaattgtttt t" /listShort="lonB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2535822..2535827) /Source="Nicolas_upshift_promotors" /id="U2183" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.66933066933067" /psig="0.66933066933067" /xcortree=1167 /SigmaFactorBS="aggtttttttgcatgcaactcttccggaaaaaCGTTTAttcc cgtcttctatgGGAGATACTAGCAATCAGAggaatgaattggatacataaattgtttt t" /listShort="lonB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2535896..2537158) /gene="clpX" /locus_tag="BSU_28220" /old_locus_tag="BSU28220" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11395451, 11807061, 12354604, 12761164, 14679237, 15948963, 16899079, 17827297, 17981983, 18662407, 19136590, 25433860, 27014237" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11395451, 11807061, 12354604, 12761164, 14679237, 15948963, 16899079, 17827297, 17981983, 18662407, 19136590, 25433860, 27014237; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein unfolding ATPase required for presentation of proteins to proteases; Maxwell's demon" /protein_id="NP_390700.2" /db_xref="EnsemblGenomes-Gn:BSU28220" /db_xref="EnsemblGenomes-Tr:CAB14782" /db_xref="GOA:P50866" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR003959" /db_xref="InterPro:IPR004487" /db_xref="InterPro:IPR010603" /db_xref="InterPro:IPR019489" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11387" /db_xref="UniProtKB/Swiss-Prot:P50866" /translation="MFKFNEEKGQLKCSFCGKTQDQVRKLVAGPGVYICDECIELCTE IVEEELGTEEEVEFKDVPKPQEIREILNEYVIGQDQAKKSLAVAVYNHYKRINSNSKV DDVELSKSNISLIGPTGSGKTLLAQTLARILNVPFAIADATSLTEAGYVGEDVENILL KLIQAADYDVEKAEKGIIYIDEIDKVARKSENPSITRDVSGEGVQQALLKILEGTVAS VPPQGGRKHPHQEFIQIDTTNILFICGGAFDGIEQIIKRRLGQKVIGFGADNKAADLE KEDLLSKVLPEDLLRFGLIPEFIGRLPVIASLEKLDEEALVAILTKPKNALVKQFKKM LELDNVELEFEEEALSEIAKKAIERKTGARGLRSIIEGIMLDVMFELPSRDDIEKCVI TGATVTHGEPPRLLLKDGTEVSQDKTSA*" /label="clpX CDS" gene complement(2535896..2537158) /gene="clpX" /locus_tag="BSU_28220" /old_locus_tag="BSU28220" /label="clpX gene" downshifts complement(2535906) /Source="Nicolas_upshifts" /id="D1443" /incds=0 /nref=256 /ntot=333 /MaxReadThrough="2.8818" /MaxDrop="7.82186" /score="40.299167" /energy="-18.9" /TU="U2185" /idTUdmin="U2184" /TUdmin="-19" /isTUend="TRUE" /label="downshifts" S_feature complement(2537159..2537248) /Source="Nicolas_S_feature" /locus_tag="new_2886044_2886133_c" /HighExp="dia15, dia5, Salt, Diami, C90, H2O2, Paraq, Oxctl, S1, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="SigA, SigA, SigA" /TUlongPSig="1, 0.998, 0.896" /label="S1067" promotor_-10 complement(2537236..2537255) /Source="Nicolas_upshift_promotors" /id="U2184" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=1875 /SigmaFactorBS="atacatatagaatgtgcaagtcagaaacacattgTTACCGTC tttttggaaagTATGGTAAAATGCAATACATactcgttcgtttcaagaatcattttct t" /listShort="S1067, clpX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2537248) /Source="Nicolas_upshifts" /id="U2184" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=1875 /SigmaFactorBS="atacatatagaatgtgcaagtcagaaacacattgTTACCGTC tttttggaaagTATGGTAAAATGCAATACATactcgttcgtttcaagaatcattttct t" /listShort="S1067, clpX" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2537250..2537381) /Source="Nicolas_S_feature" /locus_tag="new_2886135_2886266_c" /HighExp="H2O2, dia15, Paraq, Oxctl, G180, G135, HPh, G150, LPh, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="SigA, SigA" /TUlongPSig="1, 0.896" /label="S1068" promotor_-35 complement(2537267..2537274) /Source="Nicolas_upshift_promotors" /id="U2184" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=1875 /SigmaFactorBS="atacatatagaatgtgcaagtcagaaacacattgTTACCGTC tttttggaaagTATGGTAAAATGCAATACATactcgttcgtttcaagaatcattttct t" /listShort="S1067, clpX" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2537426) /Source="Nicolas_upshifts" /id="D1444" /incds=0 /nref=4 /ntot=16 /MaxReadThrough="8.26501" /MaxDrop="4.34985" /score="-0.284489083" /energy="-10.7" /TU="U2185,U2190" /idTUdmin="U2190" /TUdmin="-153" /isTUend="FALSE" /label="downshifts" CDS complement(2537430..2538704) /gene="tig" /locus_tag="BSU_28230" /old_locus_tag="BSU28230" /EC_number="5.2.1.8" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9748346, 12224648, 16156784, 17021213" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9748346, 12224648, 16156784, 17021213; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="prolyl isomerase (trigger factor)" /protein_id="NP_390701.1" /db_xref="EnsemblGenomes-Gn:BSU28230" /db_xref="EnsemblGenomes-Tr:CAB14783" /db_xref="GOA:P80698" /db_xref="InterPro:IPR001179" /db_xref="InterPro:IPR005215" /db_xref="InterPro:IPR008880" /db_xref="InterPro:IPR008881" /db_xref="InterPro:IPR027304" /db_xref="InterPro:IPR036611" /db_xref="SubtiList:BG19023" /db_xref="UniProtKB/Swiss-Prot:P80698" /translation="MSVKWEKQEGNEGVLTVEVDAETFKTALDDAFKKVVKQVSIPGF RKGKIPRGLFEQRFGVEALYQDALDILLPVEYPKAVEEAGIEPVDRPEIDVEKIEKGE SLIFTAKVTVKPEVKLGEYKGLGIEKDDTTVTDEDVQNELKALQERQAELVVKEEGAV EEGNTVVLDFEGFVDGEAFEGGKAENYSLEVGSGSFIPGFEDQLVGLEAGAEKDVEVT FPEEYHAEDLAGKPAVFKVKIHEIKAKELPELDDEFAKDIDEEVETLAELTEKTKKRL EEAKENEADAKLREELVLKASENAEIDVPQAMVDTELDRMLKEFEQRLQMQGMNLELY TQFSGQDEAALKEQMKEDAEKRVKSNLTLEAIAKAENLEVSDEEVDAELTKMAEAYNM PVENIKQAIGSTDAMKEDLKVRKAIDFLVENR*" /label="tig CDS" gene complement(2537430..2538704) /gene="tig" /locus_tag="BSU_28230" /old_locus_tag="BSU28230" /label="tig gene" S_feature complement(2538705..2538894) /Source="Nicolas_S_feature" /locus_tag="new_2887590_2887779_c" /HighExp="H2O2, HPh, BMM, dia15, T-4.40H, G180, Paraq, Oxctl, LBGexp, MG 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="SigA, SigA" /TUlongPSig="1, 0.896" /label="S1069" promotor_-10 complement(2538881..2538900) /Source="Nicolas_upshift_promotors" /id="U2185" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.873126873126873" /psig=1 /xcortree=2561 /SigmaFactorBS="ttgaagaaatttcttatttgtaaatcgcgccatatAGTTGaa agcgctatgtgtTATGTTATAATATAGTGGTTgtatttgtgtataacgggttataaga a" /listShort="S1069, tig, S1068, S1067, clpX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2538894) /Source="Nicolas_upshifts" /id="U2185" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.873126873126873" /psig=1 /xcortree=2561 /SigmaFactorBS="ttgaagaaatttcttatttgtaaatcgcgccatatAGTTGaa agcgctatgtgtTATGTTATAATATAGTGGTTgtatttgtgtataacgggttataaga a" /listShort="S1069, tig, S1068, S1067, clpX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2538915..2538919) /Source="Nicolas_upshift_promotors" /id="U2185" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.873126873126873" /psig=1 /xcortree=2561 /SigmaFactorBS="ttgaagaaatttcttatttgtaaatcgcgccatatAGTTGaa agcgctatgtgtTATGTTATAATATAGTGGTTgtatttgtgtataacgggttataaga a" /listShort="S1069, tig, S1068, S1067, clpX" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2538932..2539936) /gene="ysoA" /locus_tag="BSU_28240" /old_locus_tag="BSU28240" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_390702.2" /db_xref="EnsemblGenomes-Gn:BSU28240" /db_xref="EnsemblGenomes-Tr:CAB14784" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="SubtiList:BG12338" /db_xref="UniProtKB/Swiss-Prot:P94569" /translation="MTHDKKNAKIIPFPHLKDRLVEKGMSSLKEKKYQEALELFSEAM KYDDTESDLHLGMAICFLELGELEEAESVCEKMLKEGYGHYFTVLQVYMTILIQLKKY EEVKSTIEAVLEENQLPAESAEQFYKLLDFSRKMTDPDREDEAWAEEYEDTIDTEKVL ASPEEQMNLIHSLKDRNVAKYTGLLKTILQDPSAHPIIKTMIVMLLAEHEYSKPVHIS KFGESLTIEPSEIVPPDAAPILHRVLRVLDETLGNENPTLYAAVEELWRRHLYVLYPF QPKLLSADLWAAALHKVGYEMHGIEIESEELHMMYEFTDRELDEACTMLKDIEEISYL *" /label="ysoA CDS" gene complement(2538932..2539936) /gene="ysoA" /locus_tag="BSU_28240" /old_locus_tag="BSU28240" /label="ysoA gene" promotor_-10 complement(2539961..2539980) /Source="Nicolas_upshift_promotors" /id="U2186" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.609390609390609" /psig=1 /xcortree=1870 /SigmaFactorBS="ttgtccggcggctttttttgcctggtgaaacctttcatttCT TGTTTTtgttcacaggtGTTGATACACTTGAACAAAAtaaatgcctgaaaggaatata g" /listShort="ysoA" /listLong="S1069, tig, S1068, S1067, clpX" /label="promotor_-10" upshifts complement(2539979) /Source="Nicolas_upshifts" /id="U2186" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.609390609390609" /psig=1 /xcortree=1870 /SigmaFactorBS="ttgtccggcggctttttttgcctggtgaaacctttcatttCT TGTTTTtgttcacaggtGTTGATACACTTGAACAAAAtaaatgcctgaaaggaatata g" /listShort="ysoA" /listLong="S1069, tig, S1068, S1067, clpX" /label="upshifts" promotor_-35 complement(2539992..2539999) /Source="Nicolas_upshift_promotors" /id="U2186" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.609390609390609" /psig=1 /xcortree=1870 /SigmaFactorBS="ttgtccggcggctttttttgcctggtgaaacctttcatttCT TGTTTTtgttcacaggtGTTGATACACTTGAACAAAAtaaatgcctgaaaggaatata g" /listShort="ysoA" /listLong="S1069, tig, S1068, S1067, clpX" /label="promotor_-35" CDS complement(2540055..2540654) /gene="leuD" /locus_tag="BSU_28250" /old_locus_tag="BSU28250" /EC_number="4.2.1.33" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15228537, 15916605; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-isopropylmalate dehydratase (small subunit)" /protein_id="NP_390703.1" /db_xref="EnsemblGenomes-Gn:BSU28250" /db_xref="EnsemblGenomes-Tr:CAB14785" /db_xref="GOA:P94568" /db_xref="InterPro:IPR000573" /db_xref="InterPro:IPR004431" /db_xref="InterPro:IPR015928" /db_xref="InterPro:IPR033940" /db_xref="SubtiList:BG11950" /db_xref="UniProtKB/Swiss-Prot:P94568" /translation="MEPLKSHTGKAAVLNRINVDTDQIIPKQFLKRIERTGYGRFAFF DWRYDANGEPNPEFELNQPVYQGASILIAGENFGCGSSREHAPWALDDYGFKIIIAPS FADIFHQNCFKNGMLPIRMPYDNWKQLVGQYENQSLQMTVDLENQLIHDSEGNQISFE VDPHWKEMLINGYDEISLTLLLEDEIKQFESQRSSWLQA*" /label="leuD CDS" gene complement(2540055..2540654) /gene="leuD" /locus_tag="BSU_28250" /old_locus_tag="BSU28250" /label="leuD gene" downshifts complement(2540076) /Source="Nicolas_upshifts" /id="D1445" /incds=0 /nref=5 /ntot=111 /MaxReadThrough="6.76876" /MaxDrop="3.81278" /score="12.2084487" /energy="-9.9" /TU="U2190,U2191" /idTUdmin="U2186" /TUdmin="-1176" /isTUend="FALSE" /label="downshifts" CDS complement(2540667..2542085) /gene="leuC" /locus_tag="BSU_28260" /old_locus_tag="BSU28260" /EC_number="4.2.1.33" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15228537, 15916605; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-isopropylmalate dehydratase (large subunit)" /protein_id="NP_390704.1" /db_xref="EnsemblGenomes-Gn:BSU28260" /db_xref="EnsemblGenomes-Tr:CAB14786" /db_xref="GOA:P80858" /db_xref="InterPro:IPR001030" /db_xref="InterPro:IPR004430" /db_xref="InterPro:IPR015931" /db_xref="InterPro:IPR015932" /db_xref="InterPro:IPR018136" /db_xref="InterPro:IPR033941" /db_xref="InterPro:IPR036008" /db_xref="SubtiList:BG11949" /db_xref="UniProtKB/Swiss-Prot:P80858" /translation="MMPRTIIEKIWDQHIVKHGEGKPDLLYIDLHLIHEVTSPQAFEG LRQKGRKVRRPQNTFATMDHNIPTVNRFEIKDEVAKRQVTALERNCEEFGVRLADLHS VDQGIVHVVGPELGLTLPGKTIVCGDSHTSTHGAFGALAFGIGTSEVEHVLSTQTLWQ QRPKTLEVRVDGTLQKGVTAKDVILAVIGKYGVKFGTGYVIEYTGEVFRNMTMDERMT VCNMSIEAGARAGLIAPDEVTFEYCKNRKYTPKGEEFDKAVEEWKALRTDPGAVYDKS IVLDGNKISPMVTWGINPGMVLPVDSEVPAPESFSAEDDKKEAIRAYEYMGLTPHQKI EDIKVEHVFIGSCTNSRMTDLRQAADMIKGKKVADSVRAIVVPGSQSVKLQAEKEGLD QIFLEAGFEWRESGCSMCLSMNNDVVPEGERCASTSNRNFEGRQGKGARTHLVSPAMA AMAAIHGHFVDVRKFYQEKTVV*" /label="leuC CDS" gene complement(2540667..2542085) /gene="leuC" /locus_tag="BSU_28260" /old_locus_tag="BSU28260" /label="leuC gene" promotor_-35 2541974..2541978 /Source="Nicolas_upshift_promotors" /id="U2187" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.98901098901099" /psig="0.001998001998002" /xcortree=28 /SigmaFactorBS="ctttcttcccttttgtctcaagccttcaaatgcctgaggagA CGTCacctcatgaatgagGTGCAaatcaatatagagaagatccggctttccctcacca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2541993..2541997 /Source="Nicolas_upshift_promotors" /id="U2187" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.98901098901099" /psig="0.001998001998002" /xcortree=28 /SigmaFactorBS="ctttcttcccttttgtctcaagccttcaaatgcctgaggagA CGTCacctcatgaatgagGTGCAaatcaatatagagaagatccggctttccctcacca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2541993 /Source="Nicolas_upshifts" /id="U2187" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.98901098901099" /psig="0.001998001998002" /xcortree=28 /SigmaFactorBS="ctttcttcccttttgtctcaagccttcaaatgcctgaggagA CGTCacctcatgaatgagGTGCAaatcaatatagagaagatccggctttccctcacca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2542135..2543232) /gene="leuB" /locus_tag="BSU_28270" /old_locus_tag="BSU28270" /EC_number="1.1.1.85" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10095787, 15228537, 15916605, 17389690" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10095787, 15228537, 15916605, 17389690; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-isopropylmalate dehydrogenase" /protein_id="NP_390705.2" /db_xref="EnsemblGenomes-Gn:BSU28270" /db_xref="EnsemblGenomes-Tr:CAB14787" /db_xref="GOA:P05645" /db_xref="InterPro:IPR004429" /db_xref="InterPro:IPR019818" /db_xref="InterPro:IPR024084" /db_xref="SubtiList:BG10675" /db_xref="UniProtKB/Swiss-Prot:P05645" /translation="MKKRIALLPGDGIGPEVLESATDVLKSVAERFNHEFEFEYGLIG GAAIDEHHNPLPEETVAACKNADAILLGAVGGPKWDQNPSELRPEKGLLSIRKQLDLF ANLRPVKVFESLSDASPLKKEYIDNVDFVIVRELTGGLYFGQPSKRYVNTEGEQEAVD TLFYKRTEIERVIREGFKMAAARKGKVTSVDKANVLESSRLWREVAEDVAQEFPDVKL EHMLVDNAAMQLIYAPNQFDVVVTENMFGDILSDEASMLTGSLGMLPSASLSSSGLHL FEPVHGSAPDIAGKGMANPFAAILSAAMLLRTSFGLEEEAKAVEDAVNKVLASGKRTR DLARSEEFSSTQAITEEVKAAIMSENTISNV*" /label="leuB CDS" gene complement(2542135..2543232) /gene="leuB" /locus_tag="BSU_28270" /old_locus_tag="BSU28270" /label="leuB gene" CDS complement(2543253..2544809) /gene="leuA" /locus_tag="BSU_28280" /old_locus_tag="BSU28280" /EC_number="2.3.3.13" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15228537, 15916605, 16330546; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-isopropylmalate synthase" /protein_id="NP_390706.1" /db_xref="EnsemblGenomes-Gn:BSU28280" /db_xref="EnsemblGenomes-Tr:CAB14788" /db_xref="GOA:P94565" /db_xref="InterPro:IPR000891" /db_xref="InterPro:IPR002034" /db_xref="InterPro:IPR005671" /db_xref="InterPro:IPR013709" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR036230" /db_xref="SubtiList:BG11948" /db_xref="UniProtKB/Swiss-Prot:P94565" /translation="MRKINFFDTTLRDGEQSPGVNLNTQEKLAIAKQLERLGADIIEA GFPASSRGDFLAVQEIARTIKNCSVTGLARCVKGDIDAAWEALKDGAQPRIHVFIATS DIHLKHKLKMTREQVIERAVGMVKYAKERFPIVQWSAEDACRTELPFLAEIVEKVIDA GASVINLPDTVGYLAPAEYGNIFKYMKENVPNIHKAKLSAHCHDDLGMAVANSLAAIE NGADQIECAVNGIGERAGNAALEEIAVALHTRKDFYQVETGITLNEIKRTSDLVSKLT GMAVPRNKAVVGDNAFAHESGIHQDGFLKEKSTYEIISPELVGVTADALVLGKHSGRH AFKDRLTALGFQFDSEEINKFFTMFKELTEKKKEITDEDLVSLILEEKVTDRKIGYEF LSLQVHYGTSQVPTATLSLKNQENAQLIQEAATGAGSVEAIYNTLERCIDKDVELLDY RIQSNRKGEDAFAQVYVRVLVNGKESAGRGIAQDVLEASAKAYLNAVNRQLVFQSNMS GLKNHTAVGS*" /label="leuA CDS" gene complement(2543253..2544809) /gene="leuA" /locus_tag="BSU_28280" /old_locus_tag="BSU28280" /label="leuA gene" promotor_-35 2543649..2543652 /Source="Nicolas_upshift_promotors" /id="U2188" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.831168831168831" /psig=1 /xcortree=1529 /SigmaFactorBS="cttgttccgtaatgtacttgcagagaaagaaattcataccca atCTTGcgatctgttactttTTCTTCTAAAATAAGAGAAAcaagatcctcatcagtga t" /listShort="S1070" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2543665..2546106 /Source="Nicolas_S_feature" /locus_tag="new_2892550_2894991" /HighExp="Lbstat, C30, T0.30H, M9-stat, T1.30H, H2O2, M0t90, T2.0H, Salt, BC" /AntisenseName="ilvC" /AntisenseCor="-0.51305153097242795" /AntisenseRegPval="-18.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1070" upshifts 2543665 /Source="Nicolas_upshifts" /id="U2188" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.831168831168831" /psig=1 /xcortree=1529 /SigmaFactorBS="cttgttccgtaatgtacttgcagagaaagaaattcataccca atCTTGcgatctgttactttTTCTTCTAAAATAAGAGAAAcaagatcctcatcagtga t" /listShort="S1070" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2543667..2543686 /Source="Nicolas_upshift_promotors" /id="U2188" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.831168831168831" /psig=1 /xcortree=1529 /SigmaFactorBS="cttgttccgtaatgtacttgcagagaaagaaattcataccca atCTTGcgatctgttactttTTCTTCTAAAATAAGAGAAAcaagatcctcatcagtga t" /listShort="S1070" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2544796..2545824) /gene="ilvC" /locus_tag="BSU_28290" /old_locus_tag="BSU28290" /EC_number="1.1.1.86" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15228537, 15916605, 25393291, 25849365; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetohydroxy-acid isomeroreductase (NADP-dependent)" /protein_id="NP_390707.1" /db_xref="EnsemblGenomes-Gn:BSU28290" /db_xref="EnsemblGenomes-Tr:CAB14789" /db_xref="GOA:P37253" /db_xref="InterPro:IPR000506" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013023" /db_xref="InterPro:IPR013116" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR014359" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10672" /db_xref="UniProtKB/Swiss-Prot:P37253" /translation="MVKVYYNGDIKENVLAGKTVAVIGYGSQGHAHALNLKESGVDVI VGVRQGKSFTQAQEDGHKVFSVKEAAAQAEIIMVLLPDEQQQKVYEAEIKDELTAGKS LVFAHGFNVHFHQIVPPADVDVFLVAPKGPGHLVRRTYEQGAGVPALFAIYQDVTGEA RDKALAYAKGIGGARAGVLETTFKEETETDLFGEQAVLCGGLSALVKAGFETLTEAGY QPELAYFECLHELKLIVDLMYEEGLAGMRYSISDTAQWGDFVSGPRVVDAKVKESMKE VLKDIQNGTFAKEWIVENQVNRPRFNAINASENEHQIEVVGRKLREMMPFVKQGKKKE AVVSVAQN*" /label="ilvC CDS" gene complement(2544796..2545824) /gene="ilvC" /locus_tag="BSU_28290" /old_locus_tag="BSU28290" /label="ilvC gene" CDS complement(2545848..2546366) /gene="ilvH" /locus_tag="BSU_28300" /old_locus_tag="BSU28300" /EC_number="2.2.1.6" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 10229948, 14702326, 15228537, 15916605; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetohydroxy-acid synthase (small subunit)" /protein_id="NP_390708.2" /db_xref="EnsemblGenomes-Gn:BSU28300" /db_xref="EnsemblGenomes-Tr:CAB14790" /db_xref="GOA:P37252" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR004789" /db_xref="InterPro:IPR019455" /db_xref="SubtiList:BG10671" /db_xref="UniProtKB/Swiss-Prot:P37252" /translation="MKRIITLTVVNRSGVLNRITGLFTKRHYNIESITVGHTETAGVS RITFVVHVEGENDVEQLTKQLNKQIDVLKVTDITNQSIVQRELALIKVVSAPSTRTEI NGIIEPFRASVVDVSRDSIVVQVTGESNKIEALIELLKPYGIKEIARTGTTAFARGTQ QKASSNKTISIV*" /label="ilvH CDS" gene complement(2545848..2546366) /gene="ilvH" /locus_tag="BSU_28300" /old_locus_tag="BSU28300" /label="ilvH gene" promotor_-35 2546087..2546090 /Source="Nicolas_upshift_promotors" /id="U2189" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.947052947052947" /psig="0.041958041958042" /xcortree=26 /SigmaFactorBS="ctatgattccattaatctctgttcttgttgaaggtgcggAGA CaaccttgattaaggcCAGCTccctctggacaatcgattgatttgtgatgtctgtgac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2546106..2546110 /Source="Nicolas_upshift_promotors" /id="U2189" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.947052947052947" /psig="0.041958041958042" /xcortree=26 /SigmaFactorBS="ctatgattccattaatctctgttcttgttgaaggtgcggAGA CaaccttgattaaggcCAGCTccctctggacaatcgattgatttgtgatgtctgtgac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2546108 /Source="Nicolas_upshifts" /id="U2189" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.947052947052947" /psig="0.041958041958042" /xcortree=26 /SigmaFactorBS="ctatgattccattaatctctgttcttgttgaaggtgcggAGA CaaccttgattaaggcCAGCTccctctggacaatcgattgatttgtgatgtctgtgac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2546363..2548087) /gene="ilvB" /locus_tag="BSU_28310" /old_locus_tag="BSU28310" /EC_number="2.2.1.6" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 10229948, 14702326, 15228537, 15916605; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetohydroxy-acid synthase (large subunit)" /protein_id="NP_390709.1" /db_xref="EnsemblGenomes-Gn:BSU28310" /db_xref="EnsemblGenomes-Tr:CAB14791" /db_xref="GOA:P37251" /db_xref="InterPro:IPR011766" /db_xref="InterPro:IPR012000" /db_xref="InterPro:IPR012001" /db_xref="InterPro:IPR012846" /db_xref="InterPro:IPR029035" /db_xref="InterPro:IPR029061" /db_xref="SubtiList:BG10670" /db_xref="UniProtKB/Swiss-Prot:P37251" /translation="MGTNVQVDSASAECTQTMSGALMLIESLKKEKVEMIFGYPGGAV LPIYDKLYNSGLVHILPRHEQGAIHAAEGYARVSGKPGVVIATSGPGATNLVTGLADA MIDSLPLVVFTGQVATSVIGSDAFQEADILGITMPVTKHSYQVRQPEDLPRIIKEAFH IATTGRPGPVLIDIPKDVATIEGEFSYDHEMNLPGYQPTTEPNYLQIRKLVEAVSSAK KPVILAGAGVLHGKASEELKNYAEQQQIPVAHTLLGLGGFPADHPLFLGMAGMHGTYT ANMALHECDLLISIGARFDDRVTGNLKHFARNAKIAHIDIDPAEIGKIMKTQIPVVGD SKIVLQELIKQDGKQSDSSEWKKQLAEWKEEYPLWYVDNEEEGFKPQKLIEYIHQFTK GEAIVATDVGQHQMWSAQFYPFQKADKWVTSGGLGTMGFGLPAAIGAQLAEKDATVVA VVGDGGFQMTLQELDVIRELNLPVKVVILNNACLGMVRQWQEIFYEERYSESKFASQP DFVKLSEAYGIKGIRISSEAEAKEKLEEALTSREPVVIDVRVASEEKVFPMVAPGKGL HEMVGVKP*" /label="ilvB CDS" gene complement(2546363..2548087) /gene="ilvB" /locus_tag="BSU_28310" /old_locus_tag="BSU28310" /label="ilvB gene" S_feature complement(2548088..2548208) /Source="Nicolas_S_feature" /locus_tag="new_2896973_2897093_c" /HighExp="T-5.40H, T-4.40H, S2, MG 120, Glucon, GM-0.2, T-2.40H, GM-0.1, HiOs, T-3.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 0.896" /TUlongSig="NA" /TUlongPSig="NA" /label="S1071" misc_RNA complement(2548209..2548455) /gene="tboILV" /locus_tag="BSU_misc_RNA_45" /product="T-box controlling synthesis of branched chain amino acids" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 1317842, 9098041, 12165569, 12547201; Product type n: RNA" /function="16.3: Control" /label="tboILV RNA" gene complement(2548209..2548455) /gene="tboILV" /locus_tag="BSU_misc_RNA_45" /label="tboILV gene" downshifts complement(2548252) /Source="Nicolas_upshifts" /id="D1446" /incds=0 /nref=18 /ntot=78 /MaxReadThrough="7.67475" /MaxDrop="4.2339" /score="5.33237345" /energy="-13.8" /TU="U2190,U2191" /idTUdmin="U2195" /TUdmin=2682 /isTUend="FALSE" /label="downshifts" S_feature complement(2548456..2548582) /Source="Nicolas_S_feature" /locus_tag="new_2897341_2897467_c" /HighExp="LoTm, HiOs, T-3.40H, BC, B60, Pyr, GM 15, T-5.40H, UNK1, MG 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 0.896" /TUlongSig="NA" /TUlongPSig="NA" /label="S1072" promotor_-10 complement(2548564..2548583) /Source="Nicolas_upshift_promotors" /id="U2190" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.867132867132867" /psig="0.998001998001998" /xcortree=2905 /SigmaFactorBS="tgattaatcaaaattgtctaataattttaaaaaatgcTGTTG ACActgcgtccaaagcgGCGTAATATGAGTTCAACAAaagataaatgcaagcttcaca a" /listShort="S1072, NA, S1071, ilvB, ilvH, ilvC, leuA, leuB, leuC, leuD, ysoA, S1069, tig, S1068" /listLong="S1067, clpX" /label="promotor_-10" upshifts complement(2548582) /Source="Nicolas_upshifts" /id="U2190" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.867132867132867" /psig="0.998001998001998" /xcortree=2905 /SigmaFactorBS="tgattaatcaaaattgtctaataattttaaaaaatgcTGTTG ACActgcgtccaaagcgGCGTAATATGAGTTCAACAAaagataaatgcaagcttcaca a" /listShort="S1072, NA, S1071, ilvB, ilvH, ilvC, leuA, leuB, leuC, leuD, ysoA, S1069, tig, S1068" /listLong="S1067, clpX" /label="upshifts" S_feature complement(2548584..2548714) /Source="Nicolas_S_feature" /locus_tag="new_2897469_2897599_c" /HighExp="Cold, S8, S0, S7, Mal, S6, G135, M9-stat, C30, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.896" /TUlongSig="NA" /TUlongPSig="NA" /label="S1073" promotor_-35 complement(2548598..2548605) /Source="Nicolas_upshift_promotors" /id="U2190" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.867132867132867" /psig="0.998001998001998" /xcortree=2905 /SigmaFactorBS="tgattaatcaaaattgtctaataattttaaaaaatgcTGTTG ACActgcgtccaaagcgGCGTAATATGAGTTCAACAAaagataaatgcaagcttcaca a" /listShort="S1072, NA, S1071, ilvB, ilvH, ilvC, leuA, leuB, leuC, leuD, ysoA, S1069, tig, S1068" /listLong="S1067, clpX" /label="promotor_-35" promotor_-10 complement(2548709..2548728) /Source="Nicolas_upshift_promotors" /id="U2191" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.747252747252747" /psig="0.896103896103896" /xcortree=310 /SigmaFactorBS="tgttataaaatcttccatgtttatataaaattaAATAattct ggtgtattCTTGATAGATTAATAAAAAAattataaaaacttttaacatttgcaattcc t" /listShort="S1073, S1072, NA, S1071, ilvB, ilvH, ilvC, leuA, leuB, leuC, leuD, ysoA" /listLong="S1069, tig, S1068, S1067, clpX" /label="promotor_-10" upshifts complement(2548718) /Source="Nicolas_upshifts" /id="U2191" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.747252747252747" /psig="0.896103896103896" /xcortree=310 /SigmaFactorBS="tgttataaaatcttccatgtttatataaaattaAATAattct ggtgtattCTTGATAGATTAATAAAAAAattataaaaacttttaacatttgcaattcc t" /listShort="S1073, S1072, NA, S1071, ilvB, ilvH, ilvC, leuA, leuB, leuC, leuD, ysoA" /listLong="S1069, tig, S1068, S1067, clpX" /label="upshifts" promotor_-35 complement(2548742..2548745) /Source="Nicolas_upshift_promotors" /id="U2191" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.747252747252747" /psig="0.896103896103896" /xcortree=310 /SigmaFactorBS="tgttataaaatcttccatgtttatataaaattaAATAattct ggtgtattCTTGATAGATTAATAAAAAAattataaaaacttttaacatttgcaattcc t" /listShort="S1073, S1072, NA, S1071, ilvB, ilvH, ilvC, leuA, leuB, leuC, leuD, ysoA" /listLong="S1069, tig, S1068, S1067, clpX" /label="promotor_-35" promotor_-35 2548840..2548849 /Source="Nicolas_upshift_promotors" /id="U2192" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1322 /SigmaFactorBS="ctgacagatcatcttgcaatccatttcaatttcggATAGGCA CTTctcttgttccctcGGCATACATTAATGATATCTtgcaaagaaaaggtgatacgat g" /listShort="ysnD, S1074, ysnE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2548863..2548882 /Source="Nicolas_upshift_promotors" /id="U2192" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1322 /SigmaFactorBS="ctgacagatcatcttgcaatccatttcaatttcggATAGGCA CTTctcttgttccctcGGCATACATTAATGATATCTtgcaaagaaaaggtgatacgat g" /listShort="ysnD, S1074, ysnE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2548865 /Source="Nicolas_upshifts" /id="U2192" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1322 /SigmaFactorBS="ctgacagatcatcttgcaatccatttcaatttcggATAGGCA CTTctcttgttccctcGGCATACATTAATGATATCTtgcaaagaaaaggtgatacgat g" /listShort="ysnD, S1074, ysnE" /GFF_Attribute="listLong" /label="upshifts" CDS 2548903..2549238 /gene="cotQ" /locus_tag="BSU_28320" /old_locus_tag="BSU28320" /experiment="publication(s) with functional evidences, PMID:19933362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19933362; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="inner spore coat protein" /protein_id="NP_390710.1" /db_xref="EnsemblGenomes-Gn:BSU28320" /db_xref="EnsemblGenomes-Tr:CAB14792" /db_xref="SubtiList:BG12335" /db_xref="UniProtKB/Swiss-Prot:P94563" /translation="MNKSFADMQGFPAGFPSFPNFPQQYYPAVPPFYQQSQQPFGGYG YGQPFSQAYSPLTTPSGMYSSFPYASGFYGQQFSGAGFSGHGGSLSAPAIHAGGFSGA PGVHGGFRY*" /label="cotQ CDS" gene 2548903..2549238 /gene="cotQ" /locus_tag="BSU_28320" /old_locus_tag="BSU28320" /label="cotQ gene" downshifts 2549232 /Source="Nicolas_upshifts" /id="D1447" /incds=0 /nref=14 /ntot=36 /MaxReadThrough="3.79194" /MaxDrop="6.48183" /score="11.836855" /energy="-13" /TU="U2192" /idTUdmin="U2193" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" promotor_-35 2549319..2549326 /Source="Nicolas_upshift_promotors" /id="U2193" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.486513486513487" /psig="0.954045954045954" /xcortree=614 /SigmaFactorBS="ttttaaaacgacttcacaagtacagtcacattttctgTCTTT ATAtttggaaacaggaTGGAATATGATTAAGATGAAttgaacgatattctgcacaatc c" /listShort="S1074" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2549340..2549359 /Source="Nicolas_upshift_promotors" /id="U2193" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.486513486513487" /psig="0.954045954045954" /xcortree=614 /SigmaFactorBS="ttttaaaacgacttcacaagtacagtcacattttctgTCTTT ATAtttggaaacaggaTGGAATATGATTAAGATGAAttgaacgatattctgcacaatc c" /listShort="S1074" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2549342..2549406 /Source="Nicolas_S_feature" /locus_tag="new_2898227_2898291" /HighExp="S5, S6, S8, S7, B36, S4, S3, B60, BT, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.954, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1074" upshifts 2549342 /Source="Nicolas_upshifts" /id="U2193" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.486513486513487" /psig="0.954045954045954" /xcortree=614 /SigmaFactorBS="ttttaaaacgacttcacaagtacagtcacattttctgTCTTT ATAtttggaaacaggaTGGAATATGATTAAGATGAAttgaacgatattctgcacaatc c" /listShort="S1074" /GFF_Attribute="listLong" /label="upshifts" CDS 2549407..2549862 /gene="ysnE" /locus_tag="BSU_28330" /old_locus_tag="BSU28330" /EC_number="2.3.1.-" /function="16.5: Explore" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17555270, 26337367; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative indole acetic acid N-acetyltransferase" /protein_id="NP_390711.1" /db_xref="EnsemblGenomes-Gn:BSU28330" /db_xref="EnsemblGenomes-Tr:CAB14793" /db_xref="GOA:P94562" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="PDB:1YX0" /db_xref="SubtiList:BG12336" /db_xref="UniProtKB/Swiss-Prot:P94562" /translation="MHIKIDDLTGRQVVSLVNEHLHSMTLMSPPESIHALGLEKLRGP EITFWSAWEGDELAGCGALKELDTRHGEIKSMRTSASHLRKGVAKQVLQHIIEEAEKR GYERLSLETGSMASFEPARKLYESFGFQYCEPFADYGEDPNSVFMTKKL*" /label="ysnE CDS" gene 2549407..2549862 /gene="ysnE" /locus_tag="BSU_28330" /old_locus_tag="BSU28330" /label="ysnE gene" promotor_-35 2549970..2549976 /Source="Nicolas_upshift_promotors" /id="U2194" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=194 /SigmaFactorBS="cacctttatgatacacgccaatgttttcaatttTGTTTAAtt caaagaacagcGGGAATTACAAACGACATGaacgatatcatgcaaattcataaaggag g" /listShort="ysnF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2549990..2550008 /Source="Nicolas_upshift_promotors" /id="U2194" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=194 /SigmaFactorBS="cacctttatgatacacgccaatgttttcaatttTGTTTAAtt caaagaacagcGGGAATTACAAACGACATGaacgatatcatgcaaattcataaaggag g" /listShort="ysnF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2549997 /Source="Nicolas_upshifts" /id="U2194" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=194 /SigmaFactorBS="cacctttatgatacacgccaatgttttcaatttTGTTTAAtt caaagaacagcGGGAATTACAAACGACATGaacgatatcatgcaaattcataaaggag g" /listShort="ysnF" /GFF_Attribute="listLong" /label="upshifts" CDS 2550046..2550867 /gene="ysnF" /locus_tag="BSU_28340" /old_locus_tag="BSU28340" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11988534, 27464829; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="putative stress response protein" /protein_id="NP_390712.3" /db_xref="EnsemblGenomes-Gn:BSU28340" /db_xref="EnsemblGenomes-Tr:CAB14794" /db_xref="InterPro:IPR019060" /db_xref="InterPro:IPR025889" /db_xref="SubtiList:BG12337" /db_xref="UniProtKB/Swiss-Prot:P94560" /translation="MKSIVGVYETPQETIAAIEGLLTKGYDSDDISVVTSRRDTDYLE SRTGTEVNQAIDAHQDESESFFDKLKDYFTMDDTATHSKALSDLDIKTDEIDKYQEDL DDGKLLVAVDTDADVIAPIDNGNALSGGFSSTNELDYTTKEEKTMPLREEQLKVDKED VQTGEVEIGKEVKTEKRDMDIPVRHDEIYVERRPVDENKTDAAPVNDSEEIRVPIVEE KLEVTKKPVVTDEVVVGKRTVEENEHISETVKKEEPRLNKEGKVDGLDDDPLNNK*" /label="ysnF CDS" gene 2550046..2550867 /gene="ysnF" /locus_tag="BSU_28340" /old_locus_tag="BSU28340" /label="ysnF gene" downshifts 2550860 /Source="Nicolas_upshifts" /id="D1448" /incds=0 /nref=8 /ntot=77 /MaxReadThrough="2.49244" /MaxDrop="8.12771" /score="22.7277041" /energy="-13.3" /TU="NA" /idTUdmin="U2194" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" downshifts 2550924 /Source="Nicolas_upshifts" /id="D1449" /incds=0 /nref=1 /ntot=38 /MaxReadThrough="1.26489" /MaxDrop="4.30778" /score="22.7277041" /energy="-13.3" /TU="NA" /idTUdmin="U2194" /TUdmin=43 /isTUend="FALSE" /label="downshifts" tRNA complement(2550931..2551004) /gene="trnSL-Arg2" /locus_tag="BSU_tRNA_84" /product="tRNA-Arg" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Arg (UCU); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnSL-Arg2 tRNA" gene complement(2550931..2551004) /gene="trnSL-Arg2" /locus_tag="BSU_tRNA_84" /label="trnSL-Arg2 gene" downshifts complement(2550965) /Source="Nicolas_upshifts" /id="D1450" /incds=0 /nref=34 /ntot=243 /MaxReadThrough="1.54905" /MaxDrop="4.72186" /score="24.0242272" /energy="-13.3" /TU="U2195,U2196" /idTUdmin="U2195" /TUdmin="-31" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2551041..2551060) /Source="Nicolas_upshift_promotors" /id="U2195" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.843156843156843" /psig=1 /xcortree=282 /SigmaFactorBS="catgaaaaaaattctaaaaaaccGTTGACTTattattgcatc ccATATATAATAAATCTTGTCGctgatagttaaagcgaaaaacaaaaaaacaaaacgt g" /listShort="trnSL-Arg2" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2551044) /Source="Nicolas_upshifts" /id="U2195" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.843156843156843" /psig=1 /xcortree=282 /SigmaFactorBS="catgaaaaaaattctaaaaaaccGTTGACTTattattgcatc ccATATATAATAAATCTTGTCGctgatagttaaagcgaaaaacaaaaaaacaaaacgt g" /listShort="trnSL-Arg2" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2551074..2551081) /Source="Nicolas_upshift_promotors" /id="U2195" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.843156843156843" /psig=1 /xcortree=282 /SigmaFactorBS="catgaaaaaaattctaaaaaaccGTTGACTTattattgcatc ccATATATAATAAATCTTGTCGctgatagttaaagcgaaaaacaaaaaaacaaaacgt g" /listShort="trnSL-Arg2" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2551135..2551644) /gene="ysnB" /locus_tag="BSU_28350" /old_locus_tag="BSU28350" /EC_number="3.1.4.-" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphoesterase" /protein_id="NP_390713.2" /db_xref="EnsemblGenomes-Gn:BSU28350" /db_xref="EnsemblGenomes-Tr:CAB14795" /db_xref="GOA:P94559" /db_xref="InterPro:IPR000979" /db_xref="InterPro:IPR020935" /db_xref="InterPro:IPR024654" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG12334" /db_xref="UniProtKB/Swiss-Prot:P94559" /translation="MNVLIISDSHGLEEELQTIAKRHEAEVDLMIHCGDSELETRHPA LEPYAVVKGNCDFAGDFKDELLLTAGSRKILVTHGHLHGIKQTLLNVYYRAEELGADV ICFGHSHIAGSEVLRGKLMINPGSIRLPRVRRTESYAILTLENDAATVRFYDQAGNEI EDLQNRVTL*" /label="ysnB CDS" gene complement(2551135..2551644) /gene="ysnB" /locus_tag="BSU_28350" /old_locus_tag="BSU28350" /label="ysnB gene" downshifts complement(2551152) /Source="Nicolas_upshifts" /id="D1451" /incds=0 /nref=87 /ntot=225 /MaxReadThrough="4.15666" /MaxDrop="5.59323" /score="24.0242272" /energy="-13.3" /TU="U2196,U2197" /idTUdmin="U2197" /TUdmin="-130" /isTUend="FALSE" /label="downshifts" CDS complement(2551660..2552256) /gene="rdgB" /locus_tag="BSU_28360" /old_locus_tag="BSU28360" /EC_number="3.6.1.66" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16322510, 17090528, 17976651, 18689515, 19943897; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="deoxyinosine/deoxyxanthosine triphosphate pyrophosphatase, promiscuous (subunit A)" /protein_id="NP_390714.1" /db_xref="EnsemblGenomes-Gn:BSU28360" /db_xref="EnsemblGenomes-Tr:CAB14796" /db_xref="GOA:P94558" /db_xref="InterPro:IPR002637" /db_xref="InterPro:IPR020922" /db_xref="InterPro:IPR029001" /db_xref="SubtiList:BG12333" /db_xref="UniProtKB/Swiss-Prot:P94558" /translation="MIIMKEAIIATHNPGKVKEFKEILEPRGYDVKSLAEIGFTEEIE ETGHTFEENAIMKAEAVAKAVNKMVIADDSGLSIDNLGGRPGVYSARYAGEQKDDQAN IEKVLSELKGIEKEQRTARFRCALAVSIPGEETKTVEGHVEGYIAEEPRGEYGFGYDP IFIVKDKDKTMAELTSDEKNKISHRADALKKLSKLLEA*" /label="rdgB CDS" gene complement(2551660..2552256) /gene="rdgB" /locus_tag="BSU_28360" /old_locus_tag="BSU28360" /label="rdgB gene" CDS complement(2552269..2553006) /gene="rph" /locus_tag="BSU_28370" /old_locus_tag="BSU28370" /EC_number="2.7.7.56" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:1624460, 19153445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1624460, 19153445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease PH" /protein_id="NP_390715.1" /db_xref="EnsemblGenomes-Gn:BSU28370" /db_xref="EnsemblGenomes-Tr:CAB14797" /db_xref="GOA:P28619" /db_xref="InterPro:IPR001247" /db_xref="InterPro:IPR002381" /db_xref="InterPro:IPR015847" /db_xref="InterPro:IPR018336" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR027408" /db_xref="InterPro:IPR036345" /db_xref="PDB:1OYP" /db_xref="PDB:1OYR" /db_xref="PDB:1OYS" /db_xref="SubtiList:BG10357" /db_xref="UniProtKB/Swiss-Prot:P28619" /translation="MRHDGRQHDELRPITFDLDFISHPEGSVLITAGNTKVICNASVE DRVPPFLRGGGKGWITAEYSMLPRATNQRTIRESSKGKISGRTMEIQRLIGRALRAVV DLEKLGERTIWIDCDVIQADGGTRTASITGAFLAMAIAIGKLIKAGTIKTNPITDFLA AISVGIDKEQGILLDLNYEEDSSAEVDMNVIMTGSGRFVELQGTGEEATFSREDLNGL LGLAEKGIQELIDKQKEVLGDSLPELK*" /label="rph CDS" gene complement(2552269..2553006) /gene="rph" /locus_tag="BSU_28370" /old_locus_tag="BSU28370" /label="rph gene" promotor_-10 complement(2553088..2553107) /Source="Nicolas_upshift_promotors" /id="U2196" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.502497502497502" /psig="0.947052947052947" /xcortree=1453 /SigmaFactorBS="acagaaccggtctccagaccatctcaagtgaatacggGTAGT TtttaaattgggattTTTGATATACTAGGAAGAAAgaggttagcgttccggctgcctc t" /listShort="rph, ysnA, ysnB, trnSL-Arg2" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2553104) /Source="Nicolas_upshifts" /id="U2196" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.502497502497502" /psig="0.947052947052947" /xcortree=1453 /SigmaFactorBS="acagaaccggtctccagaccatctcaagtgaatacggGTAGT TtttaaattgggattTTTGATATACTAGGAAGAAAgaggttagcgttccggctgcctc t" /listShort="rph, ysnA, ysnB, trnSL-Arg2" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2553117..2554217) /gene="gerM" /locus_tag="BSU_28380" /old_locus_tag="BSU28380" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:14662349, 27381174" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14662349, 27381174; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="germination (cortex hydrolysis) and sporulation (stage II, multiple polar septa) lytic enzyme" /protein_id="NP_390716.1" /db_xref="EnsemblGenomes-Gn:BSU28380" /db_xref="EnsemblGenomes-Tr:CAB14798" /db_xref="GOA:P39072" /db_xref="InterPro:IPR019606" /db_xref="SubtiList:BG10356" /db_xref="UniProtKB/Swiss-Prot:P39072" /translation="MLKKGPAVIGATCLTSALLLSGCGLFQSDKAAEEIDPPQDVTFV NDEAGANSNTTAAKKTESEKSDTAKADQASSTVMRELYLIDKNGYVVAQTLPLPKSES TAKQALEYLVQGGPVSEILPNGFRAVLPADTTVNVDIKKDGTAIADFSNEFKNYKKED EQKIVQSVTWTLTQFSSIDKVKLRINGHELKEMPVGGTPISDDLSRKDGINLETAGVN DLTATHPLTVYYLAENEDSEYYVPVTKRIDNSEKDDITAAINELAKGPSKVSGLLTDF SEDVKLVSKPKIKDGRVTLDFNQSIFGSADEKTKMISSEVLNSIVLTLTEQPDVKSVS VKVNGKSELVNEKGEKLTEPVSRPSQVNTGSF*" /label="gerM CDS" gene complement(2553117..2554217) /gene="gerM" /locus_tag="BSU_28380" /old_locus_tag="BSU28380" /label="gerM gene" promotor_-35 complement(2553122..2553127) /Source="Nicolas_upshift_promotors" /id="U2196" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.502497502497502" /psig="0.947052947052947" /xcortree=1453 /SigmaFactorBS="acagaaccggtctccagaccatctcaagtgaatacggGTAGT TtttaaattgggattTTTGATATACTAGGAAGAAAgaggttagcgttccggctgcctc t" /listShort="rph, ysnA, ysnB, trnSL-Arg2" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2553134) /Source="Nicolas_upshifts" /id="D1452" /incds=0 /nref=2 /ntot=16 /MaxReadThrough="5.80816" /MaxDrop="4.3535" /score="41.5916163" /energy="-13" /TU="U2197" /idTUdmin="U2198" /TUdmin=1209 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2554240..2554258) /Source="Nicolas_upshift_promotors" /id="U2197" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=980 /SigmaFactorBS="tatgttgcgggtttttttctgttttgccggaattcttcGGTC TAtttcctaaagaggcTCGTATACATAATAGTACAaacatccttaggagggaaaagta t" /listShort="gerM, rph, ysnA, ysnB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2554256) /Source="Nicolas_upshifts" /id="U2197" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=980 /SigmaFactorBS="tatgttgcgggtttttttctgttttgccggaattcttcGGTC TAtttcctaaagaggcTCGTATACATAATAGTACAaacatccttaggagggaaaagta t" /listShort="gerM, rph, ysnA, ysnB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2554273..2554278) /Source="Nicolas_upshift_promotors" /id="U2197" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=980 /SigmaFactorBS="tatgttgcgggtttttttctgttttgccggaattcttcGGTC TAtttcctaaagaggcTCGTATACATAATAGTACAaacatccttaggagggaaaagta t" /listShort="gerM, rph, ysnA, ysnB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2554332..2555150) /gene="rcmE" /locus_tag="BSU_28390" /old_locus_tag="BSU28390" /EC_number="5.1.1.3" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 15347750, 17610893, 17720142, 19309142; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamate racemase" /protein_id="NP_390717.2" /db_xref="EnsemblGenomes-Gn:BSU28390" /db_xref="EnsemblGenomes-Tr:CAB14799" /db_xref="GOA:P94556" /db_xref="InterPro:IPR001920" /db_xref="InterPro:IPR004391" /db_xref="InterPro:IPR015942" /db_xref="InterPro:IPR018187" /db_xref="InterPro:IPR033134" /db_xref="PDB:1ZUW" /db_xref="SubtiList:BG11964" /db_xref="UniProtKB/Swiss-Prot:P94556" /translation="MLEQPIGVIDSGVGGLTVAKEIMRQLPKENIIYVGDTKRCPYGP RPEEEVLQYTWELTNYLLENHHIKMLVIACNTATAIALDDIQRSVGIPVVGVIQPGAR AAIKVTDNQHIGVIGTENTIKSNAYEEALLALNPDLKVENLACPLLVPFVESGKFLDK TADEIVKTSLYPLKDTSIDSLILGCTHYPILKEAIQRYMGEHVNIISSGDETAREVST ILSYKGLLNQSPIAPDHQFLTTGARDQFAKIADDWFGHEVGHVECISLQEPIKR*" /label="rcmE CDS" gene complement(2554332..2555150) /gene="rcmE" /locus_tag="BSU_28390" /old_locus_tag="BSU28390" /label="rcmE gene" downshifts complement(2554344) /Source="Nicolas_upshifts" /id="D1453" /incds=0 /nref=230 /ntot=265 /MaxReadThrough="0.9265" /MaxDrop="6.72492" /score="41.5916163" /energy="-13" /TU="NA" /idTUdmin="U2198" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2555158..2555598) /gene="ysmB" /locus_tag="BSU_28400" /old_locus_tag="BSU28400" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 26577401; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (mother cell's gene expression during sporulation)" /protein_id="NP_390718.1" /db_xref="EnsemblGenomes-Gn:BSU28400" /db_xref="EnsemblGenomes-Tr:CAB14800" /db_xref="GOA:P97247" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12332" /db_xref="UniProtKB/Swiss-Prot:P97247" /translation="MTSKPLEHVADIEKSLRHIAAIIKQKGREILNQYAITPPQFVGL QWLYELGDMTIGELSGKMYLACSTTTDLIDRMQKNELVERVKDPADRRVVRIHLLPEG ERIIQEVITKRQEYLRDMFESFTDEEIAIFEKSLMKLQHEMKRK*" /label="ysmB CDS" gene complement(2555158..2555598) /gene="ysmB" /locus_tag="BSU_28400" /old_locus_tag="BSU28400" /label="ysmB gene" promotor_-10 complement(2555641..2555660) /Source="Nicolas_upshift_promotors" /id="U2198" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.862137862137862" /psig="0.997002997002997" /xcortree=2513 /SigmaFactorBS="gactaaagtcctctatttctctcctgcgagTCTTGcattttc ttcaaaaaAGAAGGAAAATAGACACGGAacgcttttgtgcgtaagagatccttgagtg a" /listShort="ysmB, racE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2555650) /Source="Nicolas_upshifts" /id="U2198" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.862137862137862" /psig="0.997002997002997" /xcortree=2513 /SigmaFactorBS="gactaaagtcctctatttctctcctgcgagTCTTGcattttc ttcaaaaaAGAAGGAAAATAGACACGGAacgcttttgtgcgtaagagatccttgagtg a" /listShort="ysmB, racE" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2555652..2555794) /Source="Nicolas_S_feature" /locus_tag="new_2904537_2904679_c" /HighExp="BT, B36, S6, S8, S7, B60, Pyr, G/S, Lbtran, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.121047" /TUshortSig="SigK, SigA" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1075" promotor_-35 complement(2555676..2555680) /Source="Nicolas_upshift_promotors" /id="U2198" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.862137862137862" /psig="0.997002997002997" /xcortree=2513 /SigmaFactorBS="gactaaagtcctctatttctctcctgcgagTCTTGcattttc ttcaaaaaAGAAGGAAAATAGACACGGAacgcttttgtgcgtaagagatccttgagtg a" /listShort="ysmB, racE" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2555839) /Source="Nicolas_upshifts" /id="D1454" /incds=0 /nref=2 /ntot=16 /MaxReadThrough="6.16749" /MaxDrop="4.6532" /score="20.9204638" /energy="-10.8" /TU="U2200,U2202" /idTUdmin="U2202" /TUdmin="-176" /isTUend="FALSE" /label="downshifts" CDS complement(2555842..2556066) /gene="gerE" /locus_tag="BSU_28410" /old_locus_tag="BSU28410" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11243786, 11418558, 11741866, 14702409, 17172339, 20435725, 21670523, 26790838" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11243786, 11418558, 11741866, 14702409, 17172339, 20435725, 21670523, 26790838; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="transcriptional regulator required for the expression of late spore coat genes" /protein_id="NP_390719.2" /db_xref="EnsemblGenomes-Gn:BSU28410" /db_xref="EnsemblGenomes-Tr:CAB14801" /db_xref="GOA:P11470" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="PDB:1FSE" /db_xref="SubtiList:BG10355" /db_xref="UniProtKB/Swiss-Prot:P11470" /translation="MKEKEFQSKPLLTKREREVFELLVQDKTTKEIASELFISEKTVR NHISNAMQKLGVKGRSQAVVELLRMGELEL*" /label="gerE CDS" gene complement(2555842..2556066) /gene="gerE" /locus_tag="BSU_28410" /old_locus_tag="BSU28410" /label="gerE gene" upshifts 2556115 /Source="Nicolas_upshifts" /id="U2199" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.481518481518482" /psig="0.838161838161838" /xcortree=697 /SigmaFactorBS="tttctccttcaagtattgtaaccctccttgctaaggtgagag cgaatcagaaacgaatgggtTTTGATATAGTCGAGATATcatatgtaagaagggcgca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 2556117..2556135 /Source="Nicolas_upshift_promotors" /id="U2199" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.481518481518482" /psig="0.838161838161838" /xcortree=697 /SigmaFactorBS="tttctccttcaagtattgtaaccctccttgctaaggtgagag cgaatcagaaacgaatgggtTTTGATATAGTCGAGATATcatatgtaagaagggcgca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(2556124..2556143) /Source="Nicolas_upshift_promotors" /id="U2200" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1352 /SigmaFactorBS="aaacgcttcttcatacacgataaactaattatcttgtaAACG TCACCTcctgcgcccttctTACATATGATATCTCGACTAtatcaaaacccattcgttt c" /listShort="gerE, S1075, ysmB, racE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2556144) /Source="Nicolas_upshifts" /id="U2200" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1352 /SigmaFactorBS="aaacgcttcttcatacacgataaactaattatcttgtaAACG TCACCTcctgcgcccttctTACATATGATATCTCGACTAtatcaaaacccattcgttt c" /listShort="gerE, S1075, ysmB, racE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2556157..2556166) /Source="Nicolas_upshift_promotors" /id="U2200" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1352 /SigmaFactorBS="aaacgcttcttcatacacgataaactaattatcttgtaAACG TCACCTcctgcgcccttctTACATATGATATCTCGACTAtatcaaaacccattcgttt c" /listShort="gerE, S1075, ysmB, racE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2556182..2556625) /gene="ysmA" /locus_tag="BSU_28420" /old_locus_tag="BSU28420" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390720.1" /db_xref="EnsemblGenomes-Gn:BSU28420" /db_xref="EnsemblGenomes-Tr:CAB14802" /db_xref="InterPro:IPR006683" /db_xref="InterPro:IPR029069" /db_xref="SubtiList:BG10354" /db_xref="UniProtKB/Swiss-Prot:P11469" /translation="MKLPAYIDMPFQEWKTSFSFFNKVSVRFSETDMFGHMNNVTPFI YFEEVRISYFKKLNMMSENKQTMTVVASQQCDYLRQVMPYEELRIYVKTSAVGSSSLT LHYLGENLEGEPCFTGAVVMVQVSKESGKAVSWTDEEKETLLHTR*" /label="ysmA CDS" gene complement(2556182..2556625) /gene="ysmA" /locus_tag="BSU_28420" /old_locus_tag="BSU28420" /label="ysmA gene" CDS complement(2556686..2557447) /gene="sdhB" /locus_tag="BSU_28430" /old_locus_tag="BSU28430" /EC_number="1.3.5.1" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11803018, 1707123, 22720735, 22389480, 22790590" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11803018, 1707123, 22720735, 22389480, 22790590; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="succinate dehydrogenase (iron-sulfur protein)" /protein_id="NP_390721.1" /db_xref="EnsemblGenomes-Gn:BSU28430" /db_xref="EnsemblGenomes-Tr:CAB14803" /db_xref="GOA:P08066" /db_xref="InterPro:IPR004489" /db_xref="InterPro:IPR009051" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR017896" /db_xref="InterPro:IPR017900" /db_xref="InterPro:IPR025192" /db_xref="InterPro:IPR036010" /db_xref="SubtiList:BG10353" /db_xref="UniProtKB/Swiss-Prot:P08066" /translation="MSEQKTIRFIITRQDTADSTPYDEEFEIPYRPNLNVISALMEIR RNPVNVKGEKTTPVTWDMNCLEEVCGACSMVINGKPRQSCTALIDQLEQPIRLKPMKT FPVVRDLQVDRSRMFDSLKKVKAWIPIDGTYDLGPGPRMPEKRRQWAYELSKCMTCGV CLEACPNVNSKSKFMGPAPMSQVRLFNAHPTGAMNKSERLEALMDEGGLADCGNSQNC VQSCPKGIPLTTSIAALNRDTNLQAFRNFFGSDRV*" /label="sdhB CDS" gene complement(2556686..2557447) /gene="sdhB" /locus_tag="BSU_28430" /old_locus_tag="BSU28430" /label="sdhB gene" downshifts complement(2556694) /Source="Nicolas_upshifts" /id="D1455" /incds=0 /nref=61 /ntot=257 /MaxReadThrough="5.46426" /MaxDrop="4.6864" /score="20.9204638" /energy="-10.8" /TU="U2202" /idTUdmin="U2205" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(2557450..2559210) /gene="sdhA" /locus_tag="BSU_28440" /old_locus_tag="BSU28440" /EC_number="1.3.5.1" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11803018, 1707123, 18535631, 22389480, 22790590" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11803018, 1707123, 18535631, 22389480, 22790590; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="succinate dehydrogenase (flavoprotein subunit)" /protein_id="NP_390722.2" /db_xref="EnsemblGenomes-Gn:BSU28440" /db_xref="EnsemblGenomes-Tr:CAB14804" /db_xref="GOA:P08065" /db_xref="InterPro:IPR003952" /db_xref="InterPro:IPR003953" /db_xref="InterPro:IPR011280" /db_xref="InterPro:IPR015939" /db_xref="InterPro:IPR027477" /db_xref="InterPro:IPR036188" /db_xref="InterPro:IPR037099" /db_xref="SubtiList:BG10352" /db_xref="UniProtKB/Swiss-Prot:P08065" /translation="MSQSSIIVVGGGLAGLMATIKAAESGMAVKLFSIVPVKRSHSVC AQGGINGAVNTKGEGDSPWEHFDDTVYGGDFLANQPPVKAMCEAAPSIIHLLDRMGVM FNRTPEGLLDFRRFGGTQHHRTAYAGATTGQQLLYALDEQVRRYEVAGLVTKYEGWEF LGAVLDDDRTCRGIVAQNLTNMQIESFRSDAVIMATGGPGIIFGKSTNSMINTGSAAS IVYQQGAYYANGEFIQIHPTAIPGDDKLRLMSESARGEGGRVWTYKDGKPWYFLEEKY PAYGNLVPRDIATREIFDVCVNQKLGINGENMVYLDLSHKDPKELDIKLGGIIEIYEK FMGDDPRKLPMKIFPAVHYSMGGLWVDYDQMTNIPGLFAAGECDYSMHGGNRLGANSL LSAIYGGMVAGPNAVKYVNGLESSAEDMSSSLFDAHVKKEEEKWADIMSMDGTENAYV LHKELGEWMTANVTVVRHNDKLLKTDDKIQELMERFKKININDTTKWSNQGAMFTRQF SNMLQLARVITLGAYNRNESRGAHYKPDYPERNDDEWLKTTMAKHVSPYEAPEFEYQD VDVSLITPRKRDYSKKKVAK*" /label="sdhA CDS" gene complement(2557450..2559210) /gene="sdhA" /locus_tag="BSU_28440" /old_locus_tag="BSU28440" /label="sdhA gene" CDS complement(2559244..2559852) /gene="sdhC" /locus_tag="BSU_28450" /old_locus_tag="BSU28450" /EC_number="1.3.5.1" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:11803018, 15849754, 16850406, 1707123, 18535631, 22389480, 22389480" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11803018, 15849754, 16850406, 1707123, 18535631, 22389480, 22389480; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="succinate dehydrogenase (cytochrome b558 subunit)" /protein_id="NP_390723.1" /db_xref="EnsemblGenomes-Gn:BSU28450" /db_xref="EnsemblGenomes-Tr:CAB14805" /db_xref="GOA:P08064" /db_xref="InterPro:IPR000701" /db_xref="InterPro:IPR011138" /db_xref="InterPro:IPR016002" /db_xref="InterPro:IPR034804" /db_xref="SubtiList:BG10351" /db_xref="UniProtKB/Swiss-Prot:P08064" /translation="MSGNREFYFRRLHSLLGVIPVGIFLIQHLVVNQFAARGAEAFNS AAHFMDSLPFRYALEIFIIFLPLIYHAVYGVYIAFTAKNNAGQYSYMRNWLFVLQRVT GIITLIFVSWHVWETRIAAQMGAEVNFDMMANILSSPAMLGFYIVGVLSTIFHFSNGL WSFAVTWGITVTPRSQRISTYVTLIIFVALSYVGLKAIFAFV*" /label="sdhC CDS" gene complement(2559244..2559852) /gene="sdhC" /locus_tag="BSU_28450" /old_locus_tag="BSU28450" /label="sdhC gene" promotor_-35 2559622..2559629 /Source="Nicolas_upshift_promotors" /id="U2201" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.545454545454545" /psig=1 /xcortree=646 /SigmaFactorBS="tagctgtattgaccggcgttatttttcgcagtaaacgcTATG TACAcaccataaactgCATGATAAATTAATGGTAAGaagataataaaaatttccaagg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2559642..2559661 /Source="Nicolas_upshift_promotors" /id="U2201" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.545454545454545" /psig=1 /xcortree=646 /SigmaFactorBS="tagctgtattgaccggcgttatttttcgcagtaaacgcTATG TACAcaccataaactgCATGATAAATTAATGGTAAGaagataataaaaatttccaagg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2559644 /Source="Nicolas_upshifts" /id="U2201" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.545454545454545" /psig=1 /xcortree=646 /SigmaFactorBS="tagctgtattgaccggcgttatttttcgcagtaaacgcTATG TACAcaccataaactgCATGATAAATTAATGGTAAGaagataataaaaatttccaagg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2559853..2559948) /Source="Nicolas_S_feature" /locus_tag="new_2908738_2908833_c" /HighExp="Lbtran, dia5, Mt0, T0.30H, T1.0H, M0t90, M40t90, T0.0H, Glucon, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.78844099999999995" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S1076" promotor_-10 complement(2559938..2559957) /Source="Nicolas_upshift_promotors" /id="U2202" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.766233766233766" /psig="0.999000999001" /xcortree=2226 /SigmaFactorBS="tcggaaaattataatttatgtacgcgtttTCTTGACGccctt ttgagggagGAGTAAAATGAAATTGTCAAtaaatcttaataaagtgcttacaattgaa a" /listShort="S1076, sdhC, sdhA, sdhB, ysmA, gerE, S1075" /listLong="ysmB, racE" /label="promotor_-10" upshifts complement(2559948) /Source="Nicolas_upshifts" /id="U2202" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.766233766233766" /psig="0.999000999001" /xcortree=2226 /SigmaFactorBS="tcggaaaattataatttatgtacgcgtttTCTTGACGccctt ttgagggagGAGTAAAATGAAATTGTCAAtaaatcttaataaagtgcttacaattgaa a" /listShort="S1076, sdhC, sdhA, sdhB, ysmA, gerE, S1075" /listLong="ysmB, racE" /label="upshifts" S_feature complement(2559950..2560571) /Source="Nicolas_S_feature" /locus_tag="new_2908835_2909456_c" /HighExp="MG 120, B36, UNK1, Fru, MG 150, BMM, Gly, Glucon, Glu, GM-0.1" /AntisenseName="yslB" /AntisenseCor="-0.44143968421748903" /AntisenseRegPval="-13.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1077" promotor_-35 complement(2559972..2559979) /Source="Nicolas_upshift_promotors" /id="U2202" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.766233766233766" /psig="0.999000999001" /xcortree=2226 /SigmaFactorBS="tcggaaaattataatttatgtacgcgtttTCTTGACGccctt ttgagggagGAGTAAAATGAAATTGTCAAtaaatcttaataaagtgcttacaattgaa a" /listShort="S1076, sdhC, sdhA, sdhB, ysmA, gerE, S1075" /listLong="ysmB, racE" /label="promotor_-35" promotor_-35 2560087..2560091 /Source="Nicolas_upshift_promotors" /id="U2203" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.612387612387612" /psig="0.995004995004995" /xcortree=2758 /SigmaFactorBS="cttaatttttcataagaattacaggatcatTCTGTaatcctc ccccctgttTGAGCTATAATATACGCAGGagagaggggagacagatatgaagtctaaa t" /listShort="yslB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_no_box 2560101..2560201 /Source="Nicolas_upshift_promotors" /id="U2204" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.631368631368631" /psig="0.024975024975025" /xcortree=1731 /SigmaFactorBS="ccctgtttgagctataatatacgcaggagagaggggagacag atatgaagtctaaatttgaagcatctattgacaacctaaaagaaattgaaatgaacgc t" /listShort="yslB" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-10 2560108..2560127 /Source="Nicolas_upshift_promotors" /id="U2203" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.612387612387612" /psig="0.995004995004995" /xcortree=2758 /SigmaFactorBS="cttaatttttcataagaattacaggatcatTCTGTaatcctc ccccctgttTGAGCTATAATATACGCAGGagagaggggagacagatatgaagtctaaa t" /listShort="yslB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2560117 /Source="Nicolas_upshifts" /id="U2203" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.612387612387612" /psig="0.995004995004995" /xcortree=2758 /SigmaFactorBS="cttaatttttcataagaattacaggatcatTCTGTaatcctc ccccctgttTGAGCTATAATATACGCAGGagagaggggagacagatatgaagtctaaa t" /listShort="yslB" /GFF_Attribute="listLong" /label="upshifts" CDS 2560145..2560591 /gene="yslB" /locus_tag="BSU_28460" /old_locus_tag="BSU28460" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390724.1" /db_xref="EnsemblGenomes-Gn:BSU28460" /db_xref="EnsemblGenomes-Tr:CAB14806" /db_xref="InterPro:IPR019642" /db_xref="InterPro:IPR024096" /db_xref="PDB:3NJC" /db_xref="SubtiList:BG11236" /db_xref="UniProtKB/Swiss-Prot:P42955" /translation="MKSKFEASIDNLKEIEMNAYAYELIREIVLPDMLGQDYSSMMYW AGKHLARKFPLESWEEFPAFFEEAGWGTLTNVSAKKQELEFELEGPIISNRLKHQKEP CFQLEAGFIAEQIQLMNDQIAESYEQVKKRADKVVLTVKWDMKDPV*" /label="yslB CDS" gene 2560145..2560591 /gene="yslB" /locus_tag="BSU_28460" /old_locus_tag="BSU28460" /label="yslB gene" upshifts 2560161 /Source="Nicolas_upshifts" /id="U2204" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.631368631368631" /psig="0.024975024975025" /xcortree=1731 /SigmaFactorBS="ccctgtttgagctataatatacgcaggagagaggggagacag atatgaagtctaaatttgaagcatctattgacaacctaaaagaaattgaaatgaacgc t" /listShort="yslB" /GFF_Attribute="listLong" /label="upshifts" downshifts 2560579 /Source="Nicolas_upshifts" /id="D1456" /incds=0 /nref=217 /ntot=255 /MaxReadThrough="2.21897" /MaxDrop="6.5759" /score="4.74486914" /energy="-10.8" /TU="NA" /idTUdmin="U2203" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(2560617) /Source="Nicolas_upshifts" /id="D1457" /incds=0 /nref=8 /ntot=160 /MaxReadThrough="5.89867" /MaxDrop="4.19639" /score="2.38159916" /energy="-10.8" /TU="U2205" /idTUdmin="U2206" /TUdmin=1270 /isTUend="FALSE" /label="downshifts" CDS complement(2560635..2561861) /gene="lysCA" /locus_tag="BSU_28470" /old_locus_tag="BSU28470" /EC_number="2.7.2.4" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2981221, 2981222, 14597663, 1980002, 8757727, 9851048" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2981221, 2981222, 14597663, 1980002, 8757727, 9851048; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="aspartokinase II alpha subunit (aa 1->408)" /protein_id="NP_390725.1" /db_xref="EnsemblGenomes-Gn:BSU28470" /db_xref="EnsemblGenomes-Tr:CAB14807" /db_xref="GOA:P08495" /db_xref="InterPro:IPR001048" /db_xref="InterPro:IPR001341" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR005260" /db_xref="InterPro:IPR018042" /db_xref="InterPro:IPR027795" /db_xref="InterPro:IPR036393" /db_xref="SubtiList:BG10350" /db_xref="UniProtKB/Swiss-Prot:P08495" /translation="MGLIVQKFGGTSVGSVEKIQNAANRAIAEKQKGHQVVVVVSAMG KSTDELVSLAKAISDQPSKREMDMLLATGEQVTISLLSMALQEKGYDAVSYTGWQAGI RTEAIHGNARITDIDTSVLADQLEKGKIVIVAGFQGMTEDCEITTLGRGGSDTTAVAL AAALKADKCDIYTDVPGVFTTDPRYVKSARKLEGISYDEMLELANLGAGVLHPRAVEF AKNYQVPLEVRSSTETEAGTLIEEESSMEQNLIVRGIAFEDQITRVTIYGLTSGLTTL STIFTTLAKRNINVDIIIQTQAEDKTGISFSVKTEDADQTVAVLEEYKDALEFEKIET ESKLAKVSIVGSGMVSNPGVAAEMFAVLAQKNILIKMVSTSEIKVSTVVSENDMVKAV ESLHDAFELSKHPSAV*" /label="lysCA CDS" CDS complement(2560635..2561126) /gene="lysCB" /locus_tag="BSU_28475" /old_locus_tag="BSU28475" /EC_number="2.7.2.4" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1980002, 2981221, 2981222, 8757727, 9851048, 14597663" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1980002, 2981221, 2981222, 8757727, 9851048, 14597663; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="aspartokinase II beta subunit (aa 246->408)" /protein_id="YP_009513994.1" /translation="MEQNLIVRGIAFEDQITRVTIYGLTSGLTTLSTIFTTLAKRNIN VDIIIQTQAEDKTGISFSVKTEDADQTVAVLEEYKDALEFEKIETESKLAKVSIVGSG MVSNPGVAAEMFAVLAQKNILIKMVSTSEIKVSTVVSENDMVKAVESLHDAFELSKHP SAV*" /label="lysCB CDS" gene complement(2560635..2561861) /gene="lysCA" /locus_tag="BSU_28470" /old_locus_tag="BSU28470" /label="lysCA gene" gene complement(2560635..2561126) /gene="lysCB" /locus_tag="BSU_28475" /old_locus_tag="BSU28475" /label="lysCB gene" downshifts complement(2561975) /Source="Nicolas_upshifts" /id="D1458" /incds=0 /nref=1 /ntot=22 /MaxReadThrough="7.23315" /MaxDrop="4.15833" /score="31.7469619" /energy="-13.5" /TU="U2205,U2206" /idTUdmin="U2207" /TUdmin=44 /isTUend="FALSE" /label="downshifts" misc_RNA complement(2561987..2562166) /gene="kswC" /locus_tag="BSU_misc_RNA_46" /product="lysine riboswitch" /experiment="publication(s) with functional evidences, PMID:14523230, 14597663, 14627808, 21169337, 22416067" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14523230, 14597663, 14627808, 21169337, 22416067; Product type n: RNA" /label="kswC RNA" gene complement(2561987..2562166) /gene="kswC" /locus_tag="BSU_misc_RNA_46" /label="kswC gene" downshifts complement(2562019) /Source="Nicolas_upshifts" /id="D1459" /incds=0 /nref=22 /ntot=132 /MaxReadThrough="7.09997" /MaxDrop="4.61976" /score="31.7469619" /energy="-13.5" /TU="U2205,U2206" /idTUdmin="U2207" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2562191..2562210) /Source="Nicolas_upshift_promotors" /id="U2205" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.472527472527473" /psig=1 /xcortree=3002 /SigmaFactorBS="gctcctttacgacaaattgcaaaaataaTGTTGTCCttttaa ataagaTCTGATAAAATGTGAACTAAtttcatagttagatcgtgttatatggtgaaga t" /listShort="NA, lysC, S1077, S1076, sdhC, sdhA, sdhB" /listLong="ysmA, gerE" /label="promotor_-10" upshifts complement(2562198) /Source="Nicolas_upshifts" /id="U2205" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.472527472527473" /psig=1 /xcortree=3002 /SigmaFactorBS="gctcctttacgacaaattgcaaaaataaTGTTGTCCttttaa ataagaTCTGATAAAATGTGAACTAAtttcatagttagatcgtgttatatggtgaaga t" /listShort="NA, lysC, S1077, S1076, sdhC, sdhA, sdhB" /listLong="ysmA, gerE" /label="upshifts" promotor_-35 complement(2562223..2562230) /Source="Nicolas_upshift_promotors" /id="U2205" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.472527472527473" /psig=1 /xcortree=3002 /SigmaFactorBS="gctcctttacgacaaattgcaaaaataaTGTTGTCCttttaa ataagaTCTGATAAAATGTGAACTAAtttcatagttagatcgtgttatatggtgaaga t" /listShort="NA, lysC, S1077, S1076, sdhC, sdhA, sdhB" /listLong="ysmA, gerE" /label="promotor_-35" CDS complement(2562231..2564003) /gene="uvrC" /locus_tag="BSU_28490" /old_locus_tag="BSU28490" /EC_number="4.1.99.3" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:8655545, 16267290, 16426634, 25713353" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8655545, 16267290, 16426634, 25713353; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="excinuclease ABC (subunit C)" /protein_id="NP_390727.2" /db_xref="EnsemblGenomes-Gn:BSU28490" /db_xref="EnsemblGenomes-Tr:CAB14809" /db_xref="GOA:P14951" /db_xref="InterPro:IPR000305" /db_xref="InterPro:IPR001162" /db_xref="InterPro:IPR001943" /db_xref="InterPro:IPR004791" /db_xref="InterPro:IPR010994" /db_xref="InterPro:IPR035901" /db_xref="InterPro:IPR036876" /db_xref="SubtiList:BG10349" /db_xref="UniProtKB/Swiss-Prot:P14951" /translation="MNKQLKEKLALLPDQPGCYLMKDRQQTVIYVGKAKVLKNRVRSY FTGSHDAKTQRLVTEIEDFEYIVTSSNLEALILEMNLIKKHDPKYNVMLKDDKTYPFI KLTHERHPRLIVTRNVKKDKGRYFGPYPNVQAARETKKLLDRLYPLRKCSKLPDRVCL YYHLGQCLAPCVKDISEETNRELVESITRFLRGGYNEVKKELEEKMHEAAENLEFERA KELRDQIAHIESTMEKQKMTMNDLVDRDVFAYAYDKGWMCVQVFFIRQGKLIERDVSM FPLYQEADEEFLTFIGQFYSKNNHFLPKEILVPDSIDQSMIEQLLETNVHQPKKGPKK ELLMLAHKNAKIALKEKFSLIERDEERSIGAVQKLGEALNIYTPHRIEAFDNSNIQGT NPVSAMIVFIDGKPYKKEYRKYKIKTVTGPDDYGSMREVVRRRYTRVLRENLPLPDLI IIDGGKGQINAARDVIENELGLDIPIAGLAKDEKHRTSNLLIGDPLEVAYLERNSQEF YLLQRIQDEVHRFAISFHRQIRGKSAFQSVLDDIPGIGEKRKKMLLKHFGSVKKMKEA SLEDIKKAGVPAAAAQLLYDKLQK*" /label="uvrC CDS" gene complement(2562231..2564003) /gene="uvrC" /locus_tag="BSU_28490" /old_locus_tag="BSU28490" /label="uvrC gene" promotor_-10 complement(2564030..2564049) /Source="Nicolas_upshift_promotors" /id="U2206" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.63936063936064" /psig=1 /xcortree=2092 /SigmaFactorBS="tgagggatcgctttttttattcgccaattgtgaaCCATAGAG aaaaacaaacgttCGTGTTAAACTGGAAATAAAggattaaacataaggaagggtaaca t" /listShort="uvrC, NA" /listLong="lysC, S1077, S1076, sdhC, sdhA, sdhB, ysmA" /label="promotor_-10" upshifts complement(2564044) /Source="Nicolas_upshifts" /id="U2206" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.63936063936064" /psig=1 /xcortree=2092 /SigmaFactorBS="tgagggatcgctttttttattcgccaattgtgaaCCATAGAG aaaaacaaacgttCGTGTTAAACTGGAAATAAAggattaaacataaggaagggtaaca t" /listShort="uvrC, NA" /listLong="lysC, S1077, S1076, sdhC, sdhA, sdhB, ysmA" /label="upshifts" promotor_-35 complement(2564063..2564070) /Source="Nicolas_upshift_promotors" /id="U2206" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.63936063936064" /psig=1 /xcortree=2092 /SigmaFactorBS="tgagggatcgctttttttattcgccaattgtgaaCCATAGAG aaaaacaaacgttCGTGTTAAACTGGAAATAAAggattaaacataaggaagggtaaca t" /listShort="uvrC, NA" /listLong="lysC, S1077, S1076, sdhC, sdhA, sdhB, ysmA" /label="promotor_-35" downshifts complement(2564133) /Source="Nicolas_upshifts" /id="D1460" /incds=0 /nref=237 /ntot=268 /MaxReadThrough="4.77689" /MaxDrop="6.41061" /score="23.4086154" /energy="-10.5" /TU="U2207,U2208" /idTUdmin="U2209" /TUdmin=373 /isTUend="FALSE" /label="downshifts" CDS complement(2564139..2564453) /gene="trxA" /locus_tag="BSU_28500" /old_locus_tag="BSU28500" /function="16.6: Maintain" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9537387, 12682299, 1459769, 15937154, 17303556, 18455736, 18601268" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9537387, 12682299, 1459769, 15937154, 17303556, 18455736, 18601268; Product type c: carrier" /codon_start=1 /transl_table=11 /product="thioredoxin" /protein_id="NP_390728.1" /db_xref="EnsemblGenomes-Gn:BSU28500" /db_xref="EnsemblGenomes-Tr:CAB14810" /db_xref="GOA:P14949" /db_xref="InterPro:IPR005746" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR017937" /db_xref="InterPro:IPR036249" /db_xref="PDB:2GZY" /db_xref="PDB:2GZZ" /db_xref="PDB:2IPA" /db_xref="PDB:2VOC" /db_xref="SubtiList:BG10348" /db_xref="UniProtKB/Swiss-Prot:P14949" /translation="MAIVKATDQSFSAETSEGVVLADFWAPWCGPCKMIAPVLEELDQ EMGDKLKIVKIDVDENQETAGKYGVMSIPTLLVLKDGEVVETSVGFKPKEALQELVNK HL*" /label="trxA CDS" gene complement(2564139..2564453) /gene="trxA" /locus_tag="BSU_28500" /old_locus_tag="BSU28500" /label="trxA gene" promotor_-10 complement(2564479..2564498) /Source="Nicolas_upshift_promotors" /id="U2207" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.496503496503497" /psig="0.995004995004995" /xcortree=1940 /SigmaFactorBS="gctgtgatcaggaaaaaataatttgtaagcattaaaaTAGcg tgaacgaatgggaGATGCTATACTAAAAATCATcatttcacattggaggaattcaata a" /listShort="trxA, uvrC, NA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2564493) /Source="Nicolas_upshifts" /id="U2207" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.496503496503497" /psig="0.995004995004995" /xcortree=1940 /SigmaFactorBS="gctgtgatcaggaaaaaataatttgtaagcattaaaaTAGcg tgaacgaatgggaGATGCTATACTAAAAATCATcatttcacattggaggaattcaata a" /listShort="trxA, uvrC, NA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2564495..2564704) /Source="Nicolas_S_feature" /locus_tag="new_2913380_2913589_c" /HighExp="Etha, Salt, Gly, Sw, M9-stat, LPhT, BC, B60, S5, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99984399999999996" /TUshortSig="SigB, SigA" /TUshortPSig="0.991, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1078" promotor_-35 complement(2564514..2564516) /Source="Nicolas_upshift_promotors" /id="U2207" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.496503496503497" /psig="0.995004995004995" /xcortree=1940 /SigmaFactorBS="gctgtgatcaggaaaaaataatttgtaagcattaaaaTAGcg tgaacgaatgggaGATGCTATACTAAAAATCATcatttcacattggaggaattcaata a" /listShort="trxA, uvrC, NA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2564598..2564708) /locus_tag="BSU_28509" /old_locus_tag="BSU28509" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="CDS C-terminal fragment" /db_xref="PSEUDO:SOX90589.1" /translation="MVKYMTVKRRCDLMLRTILMIIGAIVVIGAIIRFVF*" /label="CDS C-terminal fragment" gene complement(2564598..2564708) /locus_tag="BSU_28509" /old_locus_tag="BSU28509" /pseudo /label="gene" promotor_-10 complement(2564694..2564712) /Source="Nicolas_upshift_promotors" /id="U2208" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=165 /SigmaFactorBS="cgccggagcttcatgccggcgctctttttcaGGTTTTAaaac agctccggcaGGGCATGGTAAAGTACATGacagtgaagaggagatgtgatcttatgct t" /listShort="S1078, trxA, uvrC" /listLong="NA" /label="promotor_-10" upshifts complement(2564704) /Source="Nicolas_upshifts" /id="U2208" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=165 /SigmaFactorBS="cgccggagcttcatgccggcgctctttttcaGGTTTTAaaac agctccggcaGGGCATGGTAAAGTACATGacagtgaagaggagatgtgatcttatgct t" /listShort="S1078, trxA, uvrC" /listLong="NA" /label="upshifts" promotor_-35 complement(2564727..2564733) /Source="Nicolas_upshift_promotors" /id="U2208" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=165 /SigmaFactorBS="cgccggagcttcatgccggcgctctttttcaGGTTTTAaaac agctccggcaGGGCATGGTAAAGTACATGacagtgaagaggagatgtgatcttatgct t" /listShort="S1078, trxA, uvrC" /listLong="NA" /label="promotor_-35" CDS complement(2564776..2566263) /gene="abfB" /locus_tag="BSU_28510" /old_locus_tag="BSU28510" /EC_number="3.2.1.55" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14973026, 17827291, 18757805" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14973026, 17827291, 18757805; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exo-alpha-L-arabinofuranosidase" /protein_id="NP_390729.2" /db_xref="EnsemblGenomes-Gn:BSU28510" /db_xref="EnsemblGenomes-Tr:CAB14811" /db_xref="GOA:P94552" /db_xref="InterPro:IPR010720" /db_xref="InterPro:IPR017853" /db_xref="SubtiList:BG11985" /db_xref="UniProtKB/Swiss-Prot:P94552" /translation="MSEHQAVIQTDIAKGTINKNIYGHFAEHLGRGIYEGIWVGTDSD IPNINGIRKDVLEALKQLHIPVLRWPGGCFADEYHWANGVGDRKTMLNTHWGGTIESN EFGTHEFMMLCELLECEPYICGNVGSGTVQEMSEWIEYMTFEEGTPMSDWRKQNGREE PWKLKYFGVGNENWGCGGNMHPEYYADLYRRFQTYVRNYSGNDIYKIAGGANVDDFNW TDVLMKKAAGLMDGLSLHYYTIPGDFWKGKGSATEFTEDEWFITMKKAKYIDELIQKH GTIMDRYDPEQRVGLIIDEWGTWFDPEPGTNPGFLYQQNTIRDALVAASHFHIFHQHC RRVQMANIAQTVNVLQAMILTEGERMLLTPTYHVFNMFKVHQDASLLATETMSADYEW NGETLPQISISASKQAEGDINITICNIDHQNKAEAEIELRGLHKAADHSGVILTAEKM NAHNTFDDPHHVKPESFRQYTLSKNKLKVKLPPMSVVLLTLRADS*" /label="abfB CDS" gene complement(2564776..2566263) /gene="abfB" /locus_tag="BSU_28510" /old_locus_tag="BSU28510" /label="abfB gene" S_feature complement(2566264..2566376) /Source="Nicolas_S_feature" /locus_tag="new_2915149_2915261_c" /HighExp="T0.30H, M40t90, M0t90, BC, M9-stat, T1.30H, T1.0H, T2.0H, T2.30H, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1079" promotor_-10 complement(2566357..2566376) /Source="Nicolas_upshift_promotors" /id="U2209" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=367 /SigmaFactorBS="aaatacatacgtacaaatataaaaacaatagaaaatgtCGTT GACAtgtacgaacatataTAATATGGTTACTTTAAAAGcgcttacattcatgctgact c" /listShort="S1079, xsa, S1078" /listLong="trxA" /label="promotor_-10" upshifts complement(2566376) /Source="Nicolas_upshifts" /id="U2209" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=367 /SigmaFactorBS="aaatacatacgtacaaatataaaaacaatagaaaatgtCGTT GACAtgtacgaacatataTAATATGGTTACTTTAAAAGcgcttacattcatgctgact c" /listShort="S1079, xsa, S1078" /listLong="trxA" /label="upshifts" promotor_-35 complement(2566391..2566398) /Source="Nicolas_upshift_promotors" /id="U2209" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=367 /SigmaFactorBS="aaatacatacgtacaaatataaaaacaatagaaaatgtCGTT GACAtgtacgaacatataTAATATGGTTACTTTAAAAGcgcttacattcatgctgact c" /listShort="S1079, xsa, S1078" /listLong="trxA" /label="promotor_-35" CDS complement(2566480..2567457) /gene="etfA" /locus_tag="BSU_28520" /old_locus_tag="BSU28520" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17189250, 20059546, 21398533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17189250, 20059546, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="electron transfer flavoprotein (alpha subunit)" /protein_id="NP_390730.1" /db_xref="EnsemblGenomes-Gn:BSU28520" /db_xref="EnsemblGenomes-Tr:CAB14812" /db_xref="GOA:P94551" /db_xref="InterPro:IPR001308" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR014730" /db_xref="InterPro:IPR014731" /db_xref="InterPro:IPR018206" /db_xref="InterPro:IPR029035" /db_xref="InterPro:IPR033947" /db_xref="SubtiList:BG11934" /db_xref="UniProtKB/Swiss-Prot:P94551" /translation="MGKKVIVLGEIRDGELRNVTFEAIAAGRTISGDGEVIGVLIGEN VQSIAQELIHYGADKVLTAEDPKLKTYTADGYSQVMRGVIEQENPDSVIFGHTAMGKD LSPKLAARLQTGLISDAIDVSVTGGNVVFTRPIYSGKAFERVISTDPMIFATIRPNNI QASEKDTSRSGSIESIDVSLTDLRTVIQEVVKKTADGVDLSEAKIIVAGGRGVKSKEG FQPLQELAEVLGAAVGASRGACDADYCDYALQIGQTGKVVTPDLYIACGISGAIQHLA GMSNSKVIVAINKDPEADIFKIADYGIVGDLFEVVPLLTEEFKQLNIHS*" /label="etfA CDS" gene complement(2566480..2567457) /gene="etfA" /locus_tag="BSU_28520" /old_locus_tag="BSU28520" /label="etfA gene" downshifts complement(2566488) /Source="Nicolas_upshifts" /id="D1461" /incds=0 /nref=58 /ntot=179 /MaxReadThrough="2.43782" /MaxDrop="7.95053" /score="30.2462458" /energy="-13.5" /TU="NA" /idTUdmin="U2210" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(2567493..2568266) /gene="etfB" /locus_tag="BSU_28530" /old_locus_tag="BSU28530" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10026281, 17189250, 21398533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10026281, 17189250, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="electron transfer flavoprotein (beta subunit)" /protein_id="NP_390731.1" /db_xref="EnsemblGenomes-Gn:BSU28530" /db_xref="EnsemblGenomes-Tr:CAB14813" /db_xref="GOA:P94550" /db_xref="InterPro:IPR000049" /db_xref="InterPro:IPR012255" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR014730" /db_xref="InterPro:IPR033948" /db_xref="SubtiList:BG11935" /db_xref="UniProtKB/Swiss-Prot:P94550" /translation="MNLFVLMKRTFDTEEKIVIETGKIQDDGAEWIINPYDEYAIEEA IQLKEKHGGTITAVTVGGEEAEKELRTALAMGCDQAVLINIEDDLDEPDQYSISQVLY HYMKDQEFDLILGGNVAIDGGSGQVAPRLAELLDIPCITTITKLEINGTDAEAERDVE GDVEKIKTTLPLLVTAQQGLNEPRYPSLPGIMKAKKKPLEELELDDLDLDEEDAEPKL KTIERFLPPKKEAGKLLQGEPAEQAKELVSLLRSEAKVI*" /label="etfB CDS" gene complement(2567493..2568266) /gene="etfB" /locus_tag="BSU_28530" /old_locus_tag="BSU28530" /label="etfB gene" CDS complement(2568281..2569057) /gene="fadB" /locus_tag="BSU_28540" /old_locus_tag="BSU28540" /EC_number="4.2.1.17" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17189250, 21398533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17189250, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enoyl-CoA hydratase" /protein_id="NP_390732.1" /db_xref="EnsemblGenomes-Gn:BSU28540" /db_xref="EnsemblGenomes-Tr:CAB14814" /db_xref="GOA:P94549" /db_xref="InterPro:IPR001753" /db_xref="InterPro:IPR014748" /db_xref="InterPro:IPR018376" /db_xref="InterPro:IPR029045" /db_xref="SubtiList:BG12331" /db_xref="UniProtKB/Swiss-Prot:P94549" /translation="MNAISLAVDQFVAVLTIHNPPANALSSRILEELSSCLDQCETDA GVRSIIIHGEGRFFSAGADIKEFTSLKGNEDSSLLAERGQQLMERIESFPKPIIAAIH GAALGGGLELAMACHIRIAAEDAKLGLPELNLGIIPGFAGTQRLPRYVGTAKALELIG SGEPISGKEALDLGLVSIGAKDEAEVIEKAKALAAKFAEKSPQTLASLLELLYSNKVY SYEGSLKLEAKRFGEAFESEDAKEGIQAFLEKRKPQFKGE*" /label="fadB CDS" gene complement(2568281..2569057) /gene="fadB" /locus_tag="BSU_28540" /old_locus_tag="BSU28540" /label="fadB gene" downshifts 2568346 /Source="Nicolas_upshifts" /id="D1462" /incds=1 /nref=1 /ntot=21 /MaxReadThrough="0.92259" /MaxDrop="4.42725" /score="-8.29305955" /energy="-5.1" /TU="NA" /idTUdmin="U2203" /TUdmin=7767 /isTUend="FALSE" /label="downshifts" CDS complement(2569072..2569656) /gene="fadR" /locus_tag="BSU_28550" /old_locus_tag="BSU28550" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17189250, 18941141, 21398533, 24356978" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17189250, 18941141, 21398533, 24356978; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of fatty acids degradation [FadR-long-chain (C14-C20) acyl-CoAs]" /protein_id="NP_390733.1" /db_xref="EnsemblGenomes-Gn:BSU28550" /db_xref="EnsemblGenomes-Tr:CAB14815" /db_xref="GOA:P94548" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR013570" /db_xref="InterPro:IPR036271" /db_xref="PDB:1VI0" /db_xref="PDB:3WHB" /db_xref="PDB:3WHC" /db_xref="SubtiList:BG12330" /db_xref="UniProtKB/Swiss-Prot:P94548" /translation="MKQKRPKYMQIIDAAVEVIAENGYHQSQVSKIAKQAGVADGTIY LYFKNKEDILISLFKEKMGQFIERMEEDIKEKATAKEKLALVISKHFSLLAGDHNLAI VTQLELRQSNLELRQKINEILKGYLNILDGILTEGIQSGEIKEGLDVRLARQMIFGTI DETVTTWVMNDQKYDLVALSNSVLELLVSGIHNK*" /label="fadR CDS" gene complement(2569072..2569656) /gene="fadR" /locus_tag="BSU_28550" /old_locus_tag="BSU28550" /label="fadR gene" promotor_-10 complement(2569698..2569717) /Source="Nicolas_upshift_promotors" /id="U2210" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.596403596403596" /psig=1 /xcortree=372 /SigmaFactorBS="aaagagaacgcctatgaataaACTTGACAaacctgaaaatcC TTCTTATCATGAAATTATGaatgaatagtcattcatttctataggaaggaacgatgaa c" /listShort="fadR, fadB, etfB, etfA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2569698) /Source="Nicolas_upshifts" /id="U2210" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.596403596403596" /psig=1 /xcortree=372 /SigmaFactorBS="aaagagaacgcctatgaataaACTTGACAaacctgaaaatcC TTCTTATCATGAAATTATGaatgaatagtcattcatttctataggaaggaacgatgaa c" /listShort="fadR, fadB, etfB, etfA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2569730..2569737) /Source="Nicolas_upshift_promotors" /id="U2210" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.596403596403596" /psig=1 /xcortree=372 /SigmaFactorBS="aaagagaacgcctatgaataaACTTGACAaacctgaaaatcC TTCTTATCATGAAATTATGaatgaatagtcattcatttctataggaaggaacgatgaa c" /listShort="fadR, fadB, etfB, etfA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2569761..2571443) /gene="lcfA" /locus_tag="BSU_28560" /old_locus_tag="BSU28560" /EC_number="6.2.1.3" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17085570, 17189250, 21398533, 21673922" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17085570, 17189250, 21398533, 21673922; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="long chain acyl-CoA ligase (degradative)" /protein_id="NP_390734.1" /db_xref="EnsemblGenomes-Gn:BSU28560" /db_xref="EnsemblGenomes-Tr:CAB14816" /db_xref="GOA:P94547" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="SubtiList:BG11946" /db_xref="UniProtKB/Swiss-Prot:P94547" /translation="MQSQKPWLAEYPNDIPHELPLPNKTLQSILTDSAARFPDKTAIS FYGKKLTFHDILTDALKLAAFLQCNGLQKGDRVAVMLPNCPQTVISYYGVLFAGGIVV QTNPLYTEHELEYQLRDAQVSVIITLDLLFPKAIKMKTLSIVDQILITSVKDYLPFPK NILYPLTQKQKVHIDFDKTANIHTFASCMKQEKTELLTIPKIDPEHDIAVLQYTGGTT GAPKGVMLTHQNILANTEMCAAWMYDVKEGAEKVLGIVPFFHVYGLTAVMNYSIKLGF EMILLPKFDPLETLKIIDKHKPTLFPGAPTIYIGLLHHPELQHYDLSSIKSCLSGSAA LPVEVKQKFEKVTGGKLVEGYGLSEASPVTHANFIWGKNKPGSIGCPWPSTDAAIYSE ETGELAAPYEHGEIIVKGPQVMKGYWNKPEETAAVLRDGWLFTGDMGYMDEEGFFYIA DRKKDIIIAGGYNIYPREVEEALYEHEAIQEIVVAGVPDSYRGETVKAFVVLKKGAKA DTEELDAFARSRLAPYKVPKAYEFRKELPKTAVGKILRRRLLEEETENHHIK*" /label="lcfA CDS" gene complement(2569761..2571443) /gene="lcfA" /locus_tag="BSU_28560" /old_locus_tag="BSU28560" /label="lcfA gene" misc_feature complement(2571472..2571491) /Source="Nicolas_upshift_promotors" /id="U2211" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.411588411588412" /psig="0.985014985014985" /xcortree=352 /SigmaFactorBS="tatgagaaaaagaaagatttacctttctttttcttttttttg ccgtccaTCTGCTATAATGATAAGGTGgatctctaaaatcgaaaggggaggttttatg c" /listShort="lcfA, fadR, fadB, etfB, etfA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2571480) /Source="Nicolas_upshifts" /id="U2211" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.411588411588412" /psig="0.985014985014985" /xcortree=352 /SigmaFactorBS="tatgagaaaaagaaagatttacctttctttttcttttttttg ccgtccaTCTGCTATAATGATAAGGTGgatctctaaaatcgaaaggggaggttttatg c" /listShort="lcfA, fadR, fadB, etfB, etfA" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(2571568) /Source="Nicolas_upshifts" /id="D1463" /incds=0 /nref=8 /ntot=101 /MaxReadThrough="2.17789" /MaxDrop="3.3655" /score="10.932726" /energy="-9.8" /TU="U2212" /idTUdmin="U2212" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(2571632..2572036) /gene="yshE" /locus_tag="BSU_28570" /old_locus_tag="BSU28570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390735.1" /db_xref="EnsemblGenomes-Gn:BSU28570" /db_xref="EnsemblGenomes-Tr:CAB14817" /db_xref="GOA:P94546" /db_xref="InterPro:IPR007140" /db_xref="SubtiList:BG12329" /db_xref="UniProtKB/Swiss-Prot:P94546" /translation="MSDFWENELVEIAAYYSVAVLCLVLFLTVFELVTAYKNWEEIQK GNLAVAMATGGKILGIANVFQHSISQHNSLLQMIGWGVYGFVMLLISYFIFEFLTPRF KIDQEIENDNRAVGFISFVISVGLSFVVAAGI*" /label="yshE CDS" gene complement(2571632..2572036) /gene="yshE" /locus_tag="BSU_28570" /old_locus_tag="BSU28570" /label="yshE gene" downshifts complement(2571634) /Source="Nicolas_upshifts" /id="D1464" /incds=0 /nref=1 /ntot=75 /MaxReadThrough="3.74343" /MaxDrop="2.92029" /score="10.932726" /energy="-9.8" /TU="U2212" /idTUdmin="U2212" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" CDS complement(2572051..2574408) /gene="mutSB" /locus_tag="BSU_28580" /old_locus_tag="BSU28580" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11254128, 12719520, 22333191, 27799325" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11254128, 12719520, 22333191, 27799325; Product type f: factor" /codon_start=1 /transl_table=11 /product="homologous recombination factor" /protein_id="NP_390736.1" /db_xref="EnsemblGenomes-Gn:BSU28580" /db_xref="EnsemblGenomes-Tr:CAB14818" /db_xref="GOA:P94545" /db_xref="InterPro:IPR000432" /db_xref="InterPro:IPR002625" /db_xref="InterPro:IPR005747" /db_xref="InterPro:IPR007696" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036063" /db_xref="InterPro:IPR036187" /db_xref="SubtiList:BG12328" /db_xref="UniProtKB/Swiss-Prot:P94545" /translation="MQQKVLSALEFHKVKEQVIGHAASSLGKEMLLELKPSASIDEIK KQLDEVDEASDIIRLRGQAPFGGLVDIRGALRRAEIGSVLSPSEFTEISGLLYAVKQM KHFITQMAEDGVDIPLIHQHAEQLITLSDLERDINSCIDDHGEVLDHASETLRGIRTQ LRTLESRVRDRLESMLRSSSASKMLSDTIVTIRNDRFVIPVKQEYRSSYGGIVHDTSS SGATLFIEPQAIVDMNNSLQQAKVKEKQEIERILRVLTEKTAEYTEELFLDLQVLQTL DFIFAKARYAKAVKATKPIMNDTGFIRLKKARHPLLPPDQVVANDIELGRDFSTIVIT GPNTGGKTVTLKTLGLLTLMAQSGLHIPADEGSEAAVFEHVFADIGDEQSIEQSLSTF SSHMVNIVGILEQVNENSLVLFDELGAGTDPQEGAALAMSILDDVHRTNARVLATTHY PELKAYGYNREGVMNASVEFDIETLSPTYKLLIGVPGRSNAFEISKRLGLPDHIIGQA KSEMTAEHNEVDTMIASLEQSKKRAEEELSETESIRKEAEKLHKELQQQIIELNSKKD KMLEEAEQQAAEKVKAAMKEAEDIIHELRTIKEEHKSFKDHELINAKKRLEGAMPAFE KSKKPEKPKTQKRDFKPGDEVKVLTFGQKGTLLEKTGGNEWNVQIGILKMKVKEKDLE FIKSAPEPKKEKMITAVKGKDYHVSLELDLRGERYENALSRVEKYLDDAVLAGYPRVS IIHGKGTGALRKGVQDLLKNHRSVKSSRFGEAGEGGSGVTVVELK*" /label="mutSB CDS" gene complement(2572051..2574408) /gene="mutSB" /locus_tag="BSU_28580" /old_locus_tag="BSU28580" /label="mutSB gene" CDS complement(2574429..2576141) /gene="polX" /locus_tag="BSU_28590" /old_locus_tag="BSU28590" /EC_number="2.7.7.7" /EC_number="3.1.11.-" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:18776221, 18938175, 28254425" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18776221, 18938175, 28254425; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA polymerase/3'-5' exonuclease X" /protein_id="NP_390737.1" /db_xref="EnsemblGenomes-Gn:BSU28590" /db_xref="EnsemblGenomes-Tr:CAB14819" /db_xref="GOA:P94544" /db_xref="InterPro:IPR002054" /db_xref="InterPro:IPR003141" /db_xref="InterPro:IPR003583" /db_xref="InterPro:IPR004013" /db_xref="InterPro:IPR010996" /db_xref="InterPro:IPR016195" /db_xref="InterPro:IPR022311" /db_xref="InterPro:IPR027421" /db_xref="InterPro:IPR029398" /db_xref="InterPro:IPR037160" /db_xref="SubtiList:BG12327" /db_xref="UniProtKB/Swiss-Prot:P94544" /translation="MHKKDIIRLLETIAVYMELKGDNPFKVSAFRKAAAALEQDDRSL SEMDDMMSLSGIGKGTYSVIKEYIDEGKSSTLESLQKEVPEGLVPLLKLPGLGGKKIA KLYKELGVHDAESLKEACEQQKVQGLAGFGKKSEEKILQALGEAGKQPERFPIGYALR IAREIEEHLSQFTHIIKFSRAGSLRRARETVKDLDYIIATDHPAEVREQLLELPNIKS VIASGDTKVSVILSFEYETSVDFRLVTEEQFPTTLHHFTGSKDHNIKMRQIAKERGER ISEYGVETVETGEIKTFPSEREFYAHFGLPLIPPEIRESGQEVETYSDSIELIELGQI KGDLHMHSTWSDGAFSIREMAEACIKKGYQYMAITDHSQYLKVANGLTAERLKQQAKE IDALNAEFENFRILKGVEMDILPDGTLDYDDDVLAEMDIVIASIHSSFNQPEHVIMKR LETALTNKHVDIIAHPTGRLIGRRAGYEIDIDQLIELARKTNTALELNANPARLDLRT EHLMKANEQGVTLVINTDAHNIEMLDDMKTGVTAARKGWTETKNVLNARSLKDVEAFL KRND*" /label="polX CDS" gene complement(2574429..2576141) /gene="polX" /locus_tag="BSU_28590" /old_locus_tag="BSU28590" /label="polX gene" S_feature complement(2576142..2576214) /Source="Nicolas_S_feature" /locus_tag="new_2925027_2925099_c" /HighExp="Cold, LPhT, LBGstat, H2O2, dia15, G180, G135, Sw, G150, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1080" CDS complement(2576215..2576748) /gene="yshB" /locus_tag="BSU_28600" /old_locus_tag="BSU28600" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_390738.1" /db_xref="EnsemblGenomes-Gn:BSU28600" /db_xref="EnsemblGenomes-Tr:CAB14820" /db_xref="GOA:P94543" /db_xref="InterPro:IPR003825" /db_xref="SubtiList:BG12326" /db_xref="UniProtKB/Swiss-Prot:P94543" /translation="MLDIIILILLLMGTLLGLKRGFILQFIRLTSFILSIAFAALFYK NVAPHLHWIPAPDFSAGQPALSFFTGNLEAAYYNAIAFIVLFIIAKILLRIIGSFLSI VAGIPVIKQINQMLGAVLGFLEVYLFTFVLLYVASVLPVDALQQMMGQSSLANVIINH TPYLSGLLQELWTQYGA*" /label="yshB CDS" gene complement(2576215..2576748) /gene="yshB" /locus_tag="BSU_28600" /old_locus_tag="BSU28600" /label="yshB gene" CDS complement(2576755..2577012) /gene="zapA" /locus_tag="BSU_28610" /old_locus_tag="BSU28610" /experiment="publication(s) with functional evidences, PMID:15317782, 16796675, 18588879, 20711458, 24097947, 26258635" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15317782, 16796675, 18588879, 20711458, 24097947, 26258635; Product type r : regulator" /codon_start=1 /transl_table=11 /product="regulator of cell division" /protein_id="NP_390739.1" /db_xref="EnsemblGenomes-Gn:BSU28610" /db_xref="EnsemblGenomes-Tr:CAB14821" /db_xref="GOA:P94542" /db_xref="InterPro:IPR007838" /db_xref="InterPro:IPR023688" /db_xref="InterPro:IPR036192" /db_xref="SubtiList:BG12325" /db_xref="UniProtKB/Swiss-Prot:P94542" /translation="MSDGKKTKTTVDIYGQHFTIVGEESRAHMRYVAGIVDDKMREIN EKNPYLDINKLAVLTAVNVVHDYVKLQEKCEKLERQLKEKD*" /label="zapA CDS" gene complement(2576755..2577012) /gene="zapA" /locus_tag="BSU_28610" /old_locus_tag="BSU28610" /label="zapA gene" promotor_-10 complement(2577039..2577058) /Source="Nicolas_upshift_promotors" /id="U2212" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2168 /SigmaFactorBS="tgtatataccagtgtatcataacagcgggaggctcgtcTTTC CATTcatttaataaaCGTGTTATGATAAGAACTAGgattctcgcggaatggaggagaa a" /listShort="yshA, yshB, S1080, polX, mutSB, yshE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2577055) /Source="Nicolas_upshifts" /id="U2212" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2168 /SigmaFactorBS="tgtatataccagtgtatcataacagcgggaggctcgtcTTTC CATTcatttaataaaCGTGTTATGATAAGAACTAGgattctcgcggaatggaggagaa a" /listShort="yshA, yshB, S1080, polX, mutSB, yshE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2577070..2577077) /Source="Nicolas_upshift_promotors" /id="U2212" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2168 /SigmaFactorBS="tgtatataccagtgtatcataacagcgggaggctcgtcTTTC CATTcatttaataaaCGTGTTATGATAAGAACTAGgattctcgcggaatggaggagaa a" /listShort="yshA, yshB, S1080, polX, mutSB, yshE" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 2577095..2577114 /Source="Nicolas_upshift_promotors" /id="U2213" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.987012987012987" /psig="0.999000999001" /xcortree=2131 /SigmaFactorBS="gttcttatcataacacgtttattaaatgaatggaaagacgag cctcccgctgtTATGATACACTGGTATATACagcgaaaagtgtaaaaaaaggagatta t" /listShort="rnhC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2577102 /Source="Nicolas_upshifts" /id="U2213" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.987012987012987" /psig="0.999000999001" /xcortree=2131 /SigmaFactorBS="gttcttatcataacacgtttattaaatgaatggaaagacgag cctcccgctgtTATGATACACTGGTATATACagcgaaaagtgtaaaaaaaggagatta t" /listShort="rnhC" /GFF_Attribute="listLong" /label="upshifts" CDS 2577146..2578087 /gene="rnhC" /locus_tag="BSU_28620" /old_locus_tag="BSU28620" /EC_number="3.1.26.4" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:9888800, 10094689, 12794188, 23882084" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9888800, 10094689, 12794188, 23882084; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease HIII" /protein_id="NP_390740.1" /db_xref="EnsemblGenomes-Gn:BSU28620" /db_xref="EnsemblGenomes-Tr:CAB14822" /db_xref="GOA:P94541" /db_xref="InterPro:IPR001352" /db_xref="InterPro:IPR004641" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR024567" /db_xref="InterPro:IPR024568" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG12324" /db_xref="UniProtKB/Swiss-Prot:P94541" /translation="MSHSVIKVSLSAIDQMKMTYSGSLTASVPQGAVFQAKPPGCTIT AYQSGKVLFQGKNAAAESARWGTAEPQEKKKTAKKPADPRYAPPADIAGMSVIGSDEV GTGDYFGPMTVVCAYVDKTMLPLMKELGVKDSKDLKDPQIIEIARNLIKTIPYSLLVL KNEKYNSMQEKGMSQGKMKALLHNQAITHLLRKLDGVKPEAILIDQFAEPGVYFNHLK GRDIVKERTYFSTKAEGIHLAVAAASIIARYSFLMEMDKLSRAAGMTLPKGAGPHVDE AAAKLILKKGASALRTFTKLHFANTQKAQRLADKKRS*" /label="rnhC CDS" gene 2577146..2578087 /gene="rnhC" /locus_tag="BSU_28620" /old_locus_tag="BSU28620" /label="rnhC gene" promotor_-10 complement(2577819..2577838) /Source="Nicolas_upshift_promotors" /id="U2214" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.586413586413586" /psig="0.998001998001998" /xcortree=2466 /SigmaFactorBS="gaatatcttgcaatgattgaagcagcggcgacagcCAGGTGA AtaccttcagctttTGTGCTAAAATAGGTCCGCTccttcacaatgtctctgcccttta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2577834) /Source="Nicolas_upshifts" /id="U2214" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.586413586413586" /psig="0.998001998001998" /xcortree=2466 /SigmaFactorBS="gaatatcttgcaatgattgaagcagcggcgacagcCAGGTGA AtaccttcagctttTGTGCTAAAATAGGTCCGCTccttcacaatgtctctgcccttta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2577852..2577859) /Source="Nicolas_upshift_promotors" /id="U2214" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.586413586413586" /psig="0.998001998001998" /xcortree=2466 /SigmaFactorBS="gaatatcttgcaatgattgaagcagcggcgacagcCAGGTGA AtaccttcagctttTGTGCTAAAATAGGTCCGCTccttcacaatgtctctgcccttta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2578070 /Source="Nicolas_upshifts" /id="D1465" /incds=0 /nref=150 /ntot=232 /MaxReadThrough="1.71535" /MaxDrop="5.25365" /score="25.6336933" /energy="-13.7" /TU="NA" /idTUdmin="U2213" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(2578102) /Source="Nicolas_upshifts" /id="D1466" /incds=0 /nref=1 /ntot=5 /MaxReadThrough="2.4685" /MaxDrop="5.29665" /score="-4.45611985" /energy="-14.9" /TU="NA" /idTUdmin="U2216" /TUdmin=44 /isTUend="FALSE" /label="downshifts" CDS complement(2578123..2580537) /gene="pheT" /locus_tag="BSU_28630" /old_locus_tag="BSU28630" /EC_number="6.1.1.20" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:811647, 2127701, 2492510, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 811647, 2127701, 2492510, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phenylalanyl-tRNA synthetase (beta subunit)" /protein_id="NP_390741.1" /db_xref="EnsemblGenomes-Gn:BSU28630" /db_xref="EnsemblGenomes-Tr:CAB14823" /db_xref="GOA:P17922" /db_xref="InterPro:IPR002547" /db_xref="InterPro:IPR004532" /db_xref="InterPro:IPR005121" /db_xref="InterPro:IPR005146" /db_xref="InterPro:IPR005147" /db_xref="InterPro:IPR009061" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR020825" /db_xref="InterPro:IPR033714" /db_xref="InterPro:IPR036690" /db_xref="SubtiList:BG10875" /db_xref="UniProtKB/Swiss-Prot:P17922" /translation="MFVSYKWLEDYVDLKGMDPAVLAEKITRAGIEVEGIEYKGEGIK GVVIGHVLEREQHPNADKLNKCLVDIGAEAPVQIICGAPNVDKGQKVAVATVGAVLPG NFKIKKAKLRGEESNGMICSLQELGIESKLVAKEYAEGIFVFPNDAETGSDALAALQL DDAILELGLTPNRADAMNMLGVAYEVAAILDTEVKLPQTDYPAASEQASDYISVKIED QEANPLYTAKIIKNVTIAPSPLWMQTKLMNAGIRPHNNVVDITNFVLLEYGQPLHAFD YDRFGSKEVVVRKAAENEMIVTLDDQERKLSADHLVITNGTKAQAVAGVMGGAESEVQ EDTKTILLEAAYFNGQKVRKASKDLGLRSESSVRFEKGIDPARVRLAAERAAQLIHLY AGGEVLAGTVEEDHLTIEANNIHVSADKVSSVLGLTISKEELISIYKRLGFTVGEADD LLVVTVPSRRGDITIEEDLIEEAARLYGYDNIPSTLPETAGTTGGLTPYQAKRRKVRR FLEGAGLSQAITYSLTNEKKATAFAIEKSLNTVLALPMSEERSILRHSLVPNLLDSVS YNLARQTDSVALYEVGSVFLTKEEDTKPVETERVAGAVTGLWRKQLWQGEKKPVDFFV VKGIVEGLLDKLNVLDSIEFVQSERKQLHPGRTANILLNGSLIGFIGQVHPSLEKELD IKETYVFELDLHALLAAETAPLVYTAIPKYPSVTRDIALVTDKTVTSGQLESVIKEAG GKLLKEVTVFDVYEGEHMEEGKKSVAFSLQYVNPEQTLTEEEVTKAHSKVLKALEDTY QAVLRG*" /label="pheT CDS" gene complement(2578123..2580537) /gene="pheT" /locus_tag="BSU_28630" /old_locus_tag="BSU28630" /label="pheT gene" downshifts complement(2578146) /Source="Nicolas_upshifts" /id="D1467" /incds=0 /nref=214 /ntot=255 /MaxReadThrough="3.98669" /MaxDrop="7.11892" /score="32.4736491" /energy="-14.7" /TU="NA" /idTUdmin="U2216" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2580553..2581587) /gene="pheS" /locus_tag="BSU_28640" /old_locus_tag="BSU28640" /EC_number="6.1.1.20" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:811647, 2127701, 2492510, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 811647, 2127701, 2492510, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phenylalanyl-tRNA synthetase (alpha subunit)" /protein_id="NP_390742.1" /db_xref="EnsemblGenomes-Gn:BSU28640" /db_xref="EnsemblGenomes-Tr:CAB14824" /db_xref="GOA:P17921" /db_xref="InterPro:IPR002319" /db_xref="InterPro:IPR004188" /db_xref="InterPro:IPR004529" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR010978" /db_xref="InterPro:IPR022911" /db_xref="SubtiList:BG10874" /db_xref="UniProtKB/Swiss-Prot:P17921" /translation="MEEKLKQLEQEALEQVEAASSLKVVNDIRVQYLGKKGPITEVLR GMGKLSAEERPKMGALANEVRERIANAIADKNEKLEEEEMKQKLAGQTIDVTLPGNPV AVGGRHPLTVVIEEIEDLFIGMGYTVEEGPEVETDYYNFESLNLPKEHPARDMQDSFY ITEETLMRTQTSPVQTRTMEKHEGKGPVKIICPGKVYRRDNDDATHSHQFMQIEGLVV DKNISMSDLKGTLELVAKKMFGQDREIRLRPSFFPFTEPSVEVDVTCFKCGGNGCSVC KGTGWIEILGAGMVHPNVLKMAGFDPKEYQGFAFGMGVERIAMLKYGIDDIRHFYTND VRFISQFKQA*" /label="pheS CDS" gene complement(2580553..2581587) /gene="pheS" /locus_tag="BSU_28640" /old_locus_tag="BSU28640" /label="pheS gene" S_feature complement(2581588..2581908) /Source="Nicolas_S_feature" /locus_tag="new_2930473_2930793_c" /HighExp="HPh, Cold, GM 15, GM 10, Sw, C30, G150, MG-0.2, G135, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1081" CDS 2581669..2581875 /locus_tag="BSU_28645" /old_locus_tag="BSU28645" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513995.1" /translation="MWPRYHPYFRQTDAVVSFIDITESDSGSPLRAVYAVPATTQEVK PISGCVKNALSQRHFLPGKQLIRN*" /label="hypothetical protein CDS" gene 2581669..2581875 /locus_tag="BSU_28645" /old_locus_tag="BSU28645" /label="gene" S_feature 2581898..2582162 /Source="Nicolas_S_feature" /locus_tag="new_2930783_2931047" /HighExp="S8, S7, S6, BT, C30, B36, S5, Pyr, C90, Glucon" /AntisenseName="ysgA" /AntisenseCor="-0.23049778674462801" /AntisenseRegPval="-3.9" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.519" /TUlongSig="NA" /TUlongPSig="NA" /label="S1082" upshifts 2581898 /Source="Nicolas_upshifts" /id="U2215" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.411588411588412" /psig="0.519480519480519" /xcortree=1240 /SigmaFactorBS="ggcattttctccctggaaagcagttgatcagaaattgaggtc ctctgtcacggtttttgaaatattaTGTTCTATTATAGAGaaatccaacgcttggcgc a" /listShort="S1082" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2581903..2581922) /Source="Nicolas_upshift_promotors" /id="U2216" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2133 /SigmaFactorBS="atcctcgtgtatcacttgcgaggatagtGTTGcgccaagcgt tggaTTTCTCTATAATAGAACATAatatttcaaaaaccgtgacagaggacctcaattt c" /listShort="S1081, pheS, pheT" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature 2581905..2581919 /Source="Nicolas_upshift_promotors" /id="U2215" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.411588411588412" /psig="0.519480519480519" /xcortree=1240 /SigmaFactorBS="ggcattttctccctggaaagcagttgatcagaaattgaggtc ctctgtcacggtttttgaaatattaTGTTCTATTATAGAGaaatccaacgcttggcgc a" /listShort="S1082" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2581908) /Source="Nicolas_upshifts" /id="U2216" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2133 /SigmaFactorBS="atcctcgtgtatcacttgcgaggatagtGTTGcgccaagcgt tggaTTTCTCTATAATAGAACATAatatttcaaaaaccgtgacagaggacctcaattt c" /listShort="S1081, pheS, pheT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2581937..2581940) /Source="Nicolas_upshift_promotors" /id="U2216" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2133 /SigmaFactorBS="atcctcgtgtatcacttgcgaggatagtGTTGcgccaagcgt tggaTTTCTCTATAATAGAACATAatatttcaaaaaccgtgacagaggacctcaattt c" /listShort="S1081, pheS, pheT" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2581942..2582688) /gene="rlmBB" /locus_tag="BSU_28650" /old_locus_tag="BSU28650" /EC_number="2.1.1.-" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 17114254, 24809820, 27435445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribosomal RNA methylase" /protein_id="NP_390743.1" /db_xref="EnsemblGenomes-Gn:BSU28650" /db_xref="EnsemblGenomes-Tr:CAB14825" /db_xref="GOA:P94538" /db_xref="InterPro:IPR001537" /db_xref="InterPro:IPR013123" /db_xref="InterPro:IPR029026" /db_xref="InterPro:IPR029028" /db_xref="InterPro:IPR029064" /db_xref="SubtiList:BG12323" /db_xref="UniProtKB/Swiss-Prot:P94538" /translation="MKQIESAKNQKVKDWKKLHTKKERTKTNTFLIEGEHLVEEALKS PGIVKEILVKDETRIPSDLETGIQCYMLSEDAFSAVTETETPQQIAAVCHMPEEKLAT ARKVLLIDAVQDPGNLGTMIRTADAAGLDAVVLGDGTADAFNGKTLRSAQGSHFHIPV VRRNLPSYVDELKAEGVKVYGTALQNGAPYQEIPQSESFALIVGNEGAGVDAALLEKT DLNLYVPLYGQAESLNVAVAAAILVYHLRG*" /label="rlmBB CDS" gene complement(2581942..2582688) /gene="rlmBB" /locus_tag="BSU_28650" /old_locus_tag="BSU28650" /label="rlmBB gene" promotor_-10 complement(2582715..2582734) /Source="Nicolas_upshift_promotors" /id="U2217" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.436563436563437" /psig=1 /xcortree=2411 /SigmaFactorBS="taaaatgtaatacgtatattctaaccctgcacctGGTTTATt atgtgctgttctTGCGATATAATAACATCATGttaaaaaaaggagcgccacatagaca g" /listShort="ysgA" /listLong="S1081, pheS, pheT" /label="promotor_-10" promotor_-35 2582721..2582727 /Source="Nicolas_upshift_promotors" /id="U2218" /multdbtbs="SigG,SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=944 /SigmaFactorBS="tgtggcgctcctttttttaacatgatGTTATTAtatcgcaag aacaGCACATAATAAAccaggtgcagggttagaatatacgtattacattttagaaaaa g" /listShort="sspI, ysfB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2582728) /Source="Nicolas_upshifts" /id="U2217" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.436563436563437" /psig=1 /xcortree=2411 /SigmaFactorBS="taaaatgtaatacgtatattctaaccctgcacctGGTTTATt atgtgctgttctTGCGATATAATAACATCATGttaaaaaaaggagcgccacatagaca g" /listShort="ysgA" /listLong="S1081, pheS, pheT" /label="upshifts" promotor_-10 2582741..2582752 /Source="Nicolas_upshift_promotors" /id="U2218" /multdbtbs="SigG,SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=944 /SigmaFactorBS="tgtggcgctcctttttttaacatgatGTTATTAtatcgcaag aacaGCACATAATAAAccaggtgcagggttagaatatacgtattacattttagaaaaa g" /listShort="sspI, ysfB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2582748..2582754) /Source="Nicolas_upshift_promotors" /id="U2217" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.436563436563437" /psig=1 /xcortree=2411 /SigmaFactorBS="taaaatgtaatacgtatattctaaccctgcacctGGTTTATt atgtgctgttctTGCGATATAATAACATCATGttaaaaaaaggagcgccacatagaca g" /listShort="ysgA" /listLong="S1081, pheS, pheT" /label="promotor_-35" upshifts 2582755 /Source="Nicolas_upshifts" /id="U2218" /multdbtbs="SigG,SigG" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=944 /SigmaFactorBS="tgtggcgctcctttttttaacatgatGTTATTAtatcgcaag aacaGCACATAATAAAccaggtgcagggttagaatatacgtattacattttagaaaaa g" /listShort="sspI, ysfB" /GFF_Attribute="listLong" /label="upshifts" CDS 2582807..2583022 /gene="sspI" /locus_tag="BSU_28660" /old_locus_tag="BSU28660" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:8171126, 10806362, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8171126, 10806362, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="NP_390744.1" /db_xref="EnsemblGenomes-Gn:BSU28660" /db_xref="EnsemblGenomes-Tr:CAB14826" /db_xref="GOA:P94537" /db_xref="InterPro:IPR017525" /db_xref="SubtiList:BG12318" /db_xref="UniProtKB/Swiss-Prot:P94537" /translation="MDLNLRHAVIANVTGNNQEQLEHTIVDAIQSGEEKMLPGLGVLF EVIWQHASESEKNEMLKTLEGGLKPAE*" /label="sspI CDS" gene 2582807..2583022 /gene="sspI" /locus_tag="BSU_28660" /old_locus_tag="BSU28660" /label="sspI gene" S_feature complement(2583004..2584416) /Source="Nicolas_S_feature" /locus_tag="new_2931889_2933301_c" /HighExp="S6, S8, S7, BT, S5, C30, B36, S4, B60, C90" /AntisenseName="ysfB" /AntisenseCor="0.46970634471519201" /AntisenseRegPval="-15.4" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1083" promotor_-35 2583033..2583040 /Source="Nicolas_upshift_promotors" /id="U2219" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.702297702297702" /psig="0.998001998001998" /xcortree=3149 /SigmaFactorBS="attaaaacccgccgaataagacatgaaacCGGGTGACagcgc ccggttttttTCTTATATAATAAAAACATGatgagggggaacgccatgtttttacagc c" /listShort="ysfB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2583056..2583075 /Source="Nicolas_upshift_promotors" /id="U2219" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.702297702297702" /psig="0.998001998001998" /xcortree=3149 /SigmaFactorBS="attaaaacccgccgaataagacatgaaacCGGGTGACagcgc ccggttttttTCTTATATAATAAAAACATGatgagggggaacgccatgtttttacagc c" /listShort="ysfB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2583064 /Source="Nicolas_upshifts" /id="U2219" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.702297702297702" /psig="0.998001998001998" /xcortree=3149 /SigmaFactorBS="attaaaacccgccgaataagacatgaaacCGGGTGACagcgc ccggttttttTCTTATATAATAAAAACATGatgagggggaacgccatgtttttacagc c" /listShort="ysfB" /GFF_Attribute="listLong" /label="upshifts" CDS 2583091..2584197 /gene="ysfB" /locus_tag="BSU_28670" /old_locus_tag="BSU28670" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (glycolate degradation operon)" /protein_id="NP_390745.2" /db_xref="EnsemblGenomes-Gn:BSU28670" /db_xref="EnsemblGenomes-Tr:CAB14827" /db_xref="InterPro:IPR008599" /db_xref="InterPro:IPR025736" /db_xref="SubtiList:BG12319" /db_xref="UniProtKB/Swiss-Prot:P94536" /translation="MFLQPLLAKKIIAEVKKMYEREVIIVNTDGLIMAGTNDERVGQF HEGALICAKERRSVIITKEDETRLKGVKAGINLPVFFDHDVIAVFGLTGEPAEIQPFG ELLRKMTELFIKESRHLEQSQWRERMLESFMIDWLQLKEWSPSFLEKAQLLGVDLSSR RQMILIQGYEWSPHDIEQMARSWKSSYPADLFIRWGNERILINHEVPQHEQRDRLLRK ILHICSFANTASSQYTAAGAGRAVASSSLTDSYEQAEKALAVSLKRKTPIFEEDLKLD MCLTEISPGTRNEFPQRVLGKALEHQELMNTIRTFFHHDLSLKQTAEDMHIHINTLRY RLAKAEQLTGLRFDRTEDVVTMYVALYFLDQDTK*" /label="ysfB CDS" gene 2583091..2584197 /gene="ysfB" /locus_tag="BSU_28670" /old_locus_tag="BSU28670" /label="ysfB gene" promotor_-35 2584233..2584236 /Source="Nicolas_upshift_promotors" /id="U2220" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.732267732267732" /psig="0.999000999001" /xcortree=2772 /SigmaFactorBS="agagagagtttcagtttcattttttgtatgtttctccATGGa aggctttgctttttTTCTTTTACAATAGATTGAAagcgttttttgacagggggatggg t" /listShort="glcD, glcF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2584252..2584271 /Source="Nicolas_upshift_promotors" /id="U2220" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.732267732267732" /psig="0.999000999001" /xcortree=2772 /SigmaFactorBS="agagagagtttcagtttcattttttgtatgtttctccATGGa aggctttgctttttTTCTTTTACAATAGATTGAAagcgttttttgacagggggatggg t" /listShort="glcD, glcF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2584256 /Source="Nicolas_upshifts" /id="U2220" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.732267732267732" /psig="0.999000999001" /xcortree=2772 /SigmaFactorBS="agagagagtttcagtttcattttttgtatgtttctccATGGa aggctttgctttttTTCTTTTACAATAGATTGAAagcgttttttgacagggggatggg t" /listShort="glcD, glcF" /GFF_Attribute="listLong" /label="upshifts" CDS 2584300..2585712 /gene="glcD" /locus_tag="BSU_28680" /old_locus_tag="BSU28680" /EC_number="1.1.99.14" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8606183, 25217009; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycolate oxidase subunit" /protein_id="NP_390746.1" /db_xref="EnsemblGenomes-Gn:BSU28680" /db_xref="EnsemblGenomes-Tr:CAB14828" /db_xref="GOA:P94535" /db_xref="InterPro:IPR004113" /db_xref="InterPro:IPR004490" /db_xref="InterPro:IPR006094" /db_xref="InterPro:IPR016164" /db_xref="InterPro:IPR016166" /db_xref="InterPro:IPR016167" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR016171" /db_xref="InterPro:IPR036318" /db_xref="SubtiList:BG12320" /db_xref="UniProtKB/Swiss-Prot:P94535" /translation="MITKDVKEQLIQVSGPENFDDSNAGRLVYSYDATPQYQSMPDAV IAPRNTDEISRILTICSEHRVPIVPRGSGTNLCGGTCPTEGGLVLLFKHMNQILEIDE ENLTATVQPGVITLDMIRAVESKGLFYPPDPSSMKISTIGGNINENSGGLRGLKYGVT RDYVIGLEVVLANGDIIRTGGKLAKDVAGYDLTRLFVGSEGTLGIVTEAIVKLVPKPE TKKTLLALYENIDAAAQTVSDIIAAKIIPATLEFLDQPTLLVIEDYAKIGLPTSAKAV LLIEQDGPFETVERDMEKIEAICKKGDAVSVQTAQTEEEAFALTEARRSALSALARLK PTTILEDATVPRSEIANMVKAINDIAAKYDISICTFGHAGDGNLHPTCTTDIRNKDEM ERVEQAFAEIFEKAIELGGTITGEHGVGEMKAPYLEMKLKKEGIDAMKALKAAFDPRN ILNPGKMFAKDARKRVVAER*" /label="glcD CDS" gene 2584300..2585712 /gene="glcD" /locus_tag="BSU_28680" /old_locus_tag="BSU28680" /label="glcD gene" promotor_-10 complement(2584402..2584421) /Source="Nicolas_upshift_promotors" /id="U2221" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1308 /SigmaFactorBS="aattgttaaaatgcgtgatatttcatcagtattCCTCGGAGC AatcacggcatcaGGCATAGACTGATACTGAGGcgtcgcatcatatgaatagacgaga c" /listShort="S1083" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2584416) /Source="Nicolas_upshifts" /id="U2221" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1308 /SigmaFactorBS="aattgttaaaatgcgtgatatttcatcagtattCCTCGGAGC AatcacggcatcaGGCATAGACTGATACTGAGGcgtcgcatcatatgaatagacgaga c" /listShort="S1083" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2584434..2584443) /Source="Nicolas_upshift_promotors" /id="U2221" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1308 /SigmaFactorBS="aattgttaaaatgcgtgatatttcatcagtattCCTCGGAGC AatcacggcatcaGGCATAGACTGATACTGAGGcgtcgcatcatatgaatagacgaga c" /listShort="S1083" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2585709..2587043 /gene="glcF" /locus_tag="BSU_28690" /old_locus_tag="BSU28690" /EC_number="1.1.99.14" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8606183, 25217009; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycolate oxidase (iron-sulfur subunit)" /protein_id="NP_390747.1" /db_xref="EnsemblGenomes-Gn:BSU28690" /db_xref="EnsemblGenomes-Tr:CAB14829" /db_xref="GOA:P94534" /db_xref="InterPro:IPR004017" /db_xref="InterPro:IPR009051" /db_xref="InterPro:IPR012257" /db_xref="InterPro:IPR017896" /db_xref="InterPro:IPR017900" /db_xref="SubtiList:BG12321" /db_xref="UniProtKB/Swiss-Prot:P94534" /translation="MTTEKEMKQIQNEFKERMDEGELLNCMRCGFCLPSCPTYIESGF QETHSPRGRIALMKAVADGMIEPDEDVERSLSLCLGCRACEPVCPSGVKYGQLLEEAR DIIHQNKKHSLGERVMRKTAFHELFPHQNRMRSAVSLIGLYQRSGLQTAVRKSGMLRV LPEHLRTMEAVLPDVPKSKDMKHRPRFLPSIGPMKKRVAFFSGCLMDTMFLPTNNATL KLLQLAGCDIVIPPEQACCGALHGHSGEKNTGKELAKQNIAAFEALDVDAVITNAGGC GAFLTEYDHLLKDDPEWSERAAAFVQKLKDFSSVLVELDFHQMDLALETPQVVTYQDS CHLRNVMHTSLEPRQLLKSIKGAEFKEMEKADSCCGSAGIYNIVEVEMSMKILDSKMA AVKATEAILIVTANPGCLLQMKLGIEREGLSGKVRAVHLADLLLEAAGHKTS*" /label="glcF CDS" gene 2585709..2587043 /gene="glcF" /locus_tag="BSU_28690" /old_locus_tag="BSU28690" /label="glcF gene" Polymorphism join(2586742,2586744) /Source="geneious" /ID="SNP_BsDelta6_2935628_2935628" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change /CDS_Position=1035 /Change="C -> T" /Codon_Change="CTC -> CTT" /Coverage=142 /locus_tag="BSU_28690" /Protein_Effect="None" /Reference_Frequency="1.4%" /Reference_Nucleotides="C" /Variant_Nucleotides="T" /Variant_P_Value=0 /Variant_Raw_Frequency=140 /comment="silent" /modified_by="User" / /label="Polymorphism_Delta6" downshifts 2587041 /Source="Nicolas_upshifts" /id="D1468" /incds=0 /nref=48 /ntot=148 /MaxReadThrough="3.07756" /MaxDrop="5.25031" /score="4.55188138" /energy="-14.3" /TU="U2220" /idTUdmin="U2220" /TUdmin="-181" /isTUend="FALSE" /label="downshifts" downshifts complement(2587080) /Source="Nicolas_upshifts" /id="D1469" /incds=0 /nref=27 /ntot=221 /MaxReadThrough="1.51397" /MaxDrop="5.34865" /score="-5.71907967" /energy="-14.3" /TU="NA" /idTUdmin="U2222" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(2587082..2587324) /gene="ysfE" /locus_tag="BSU_28700" /old_locus_tag="BSU28700" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390748.1" /db_xref="EnsemblGenomes-Gn:BSU28700" /db_xref="EnsemblGenomes-Tr:CAB14830" /db_xref="InterPro:IPR025870" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG12322" /db_xref="UniProtKB/Swiss-Prot:P94533" /translation="MALNTRESARDITALDIPDTSASNTFEIGFVTENVEAVIKRMRE QGVSIIGEPKVKPWGQTVAYIADPDGHYIEICSPME*" /label="ysfE CDS" gene complement(2587082..2587324) /gene="ysfE" /locus_tag="BSU_28700" /old_locus_tag="BSU28700" /label="ysfE gene" S_feature complement(2587325..2587496) /Source="Nicolas_S_feature" /locus_tag="new_2936210_2936381_c" /HighExp="Sw, M0t90, M40t90, M9-stat, T2.0H, BC, T0.30H, Lbstat, T2.30H, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigH, SigA" /TUshortPSig="0.999, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1084" CDS complement(2587384..2587554) /locus_tag="BSU_28709" /old_locus_tag="BSU28709" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513996.1" /translation="MGADVERSELKDGSIYTGLEGLLKMLRGVGNESINEISYSIRIG QQAGYSFFTGIF*" /label="hypothetical protein CDS" gene complement(2587384..2587554) /locus_tag="BSU_28709" /old_locus_tag="BSU28709" /label="gene" CDS complement(2587497..2589293) /gene="cstA" /locus_tag="BSU_28710" /old_locus_tag="BSU28710" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 1848300, 17320232, 19682248" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 1848300, 17320232, 19682248; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="carbon starvation-induced membrane protein" /protein_id="NP_390749.2" /db_xref="EnsemblGenomes-Gn:BSU28710" /db_xref="EnsemblGenomes-Tr:CAB14831" /db_xref="GOA:P94532" /db_xref="InterPro:IPR003706" /db_xref="InterPro:IPR025299" /db_xref="SubtiList:BG11924" /db_xref="UniProtKB/Swiss-Prot:P94532" /translation="MNAVTIVIASMCILAIAYRLYGTFMMVKVLKVNDDKPTPAHALE DGKDYVPTNKWVSFGHHFAAIAAAGPLVGPILAAQFGYLPGLLWLLIGAVIGGAVHDI VVLFASMRKNGKSLSEVAKDELGPVAGFCTGLSMLFIITITMAGLSMVVLHALERNPW GTFAVGITIPIAMGVGLFYKKTGNLKLASTVGFLFLMAGVFIGPWVQTTALGDFLTLD TKTLAIALPVYAFFAAALPVWLLLAPRDYLSSFMKIGVFIALIVGVFVVNPSIPFPAF TEFVKGGGPVLAGPVWPFISITIACGAISGFHAFVGSGTTPKMLNKWSDMKPVAFGAM LVECLVGIMALIAATALQPADYFAINSTPEVFRTLGMNVVHLPELSGEIGLDLEGRTG GAVTLAVGMTYIFTGMPFFSHLASYFFQFVIMFEAVFILTAIDAGTRVARYLIQDFFG EVYKPLKKTDWIPGSVFASALACLMWGYLLYSGDIGSIWALFGVSNQLMASVGLIIGA TIVLKIADKRRYILTCLIPLAYLYVTVNYAGYWMVRNVYLNPEAAGYSVLNGVLSIIM LVLGFIIIVAAVKKWAQMWKDPSLRMEASIPG*" /label="cstA CDS" gene complement(2587497..2589293) /gene="cstA" /locus_tag="BSU_28710" /old_locus_tag="BSU28710" /label="cstA gene" promotor_-10 complement(2587599..2587617) /Source="Nicolas_upshift_promotors" /id="U2222" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3197 /SigmaFactorBS="ctattggatggtgcgcaatgtgtatctcaatcctgaagcaGC AGGATATagtgtattgaaTGGCGTATTATCTATCATCatgctggtgttaggcttcatc a" /listShort="S1084, ysfE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2587617) /Source="Nicolas_upshifts" /id="U2222" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3197 /SigmaFactorBS="ctattggatggtgcgcaatgtgtatctcaatcctgaagcaGC AGGATATagtgtattgaaTGGCGTATTATCTATCATCatgctggtgttaggcttcatc a" /listShort="S1084, ysfE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2587629..2587637) /Source="Nicolas_upshift_promotors" /id="U2222" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3197 /SigmaFactorBS="ctattggatggtgcgcaatgtgtatctcaatcctgaagcaGC AGGATATagtgtattgaaTGGCGTATTATCTATCATCatgctggtgttaggcttcatc a" /listShort="S1084, ysfE" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2589290 /Source="Nicolas_upshifts" /id="D1470" /incds=0 /nref=4 /ntot=49 /MaxReadThrough="0.92122" /MaxDrop="3.18629" /score="12.2066828" /energy="-15.2" /TU="NA" /idTUdmin="U2220" /TUdmin=2068 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2589318..2589337) /Source="Nicolas_upshift_promotors" /id="U2223" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.511488511488511" /psig="0.999000999001" /xcortree=369 /SigmaFactorBS="ccattccagccggctttttgtataggaaaaAATGACCgcttt tcaccatgaAATTATGATATATTTATGAAaaacagaaaaggggatgggagaaaatgaa t" /listShort="cstA, S1084, ysfE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2589328) /Source="Nicolas_upshifts" /id="U2223" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.511488511488511" /psig="0.999000999001" /xcortree=369 /SigmaFactorBS="ccattccagccggctttttgtataggaaaaAATGACCgcttt tcaccatgaAATTATGATATATTTATGAAaaacagaaaaggggatgggagaaaatgaa t" /listShort="cstA, S1084, ysfE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2589352..2589358) /Source="Nicolas_upshift_promotors" /id="U2223" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.511488511488511" /psig="0.999000999001" /xcortree=369 /SigmaFactorBS="ccattccagccggctttttgtataggaaaaAATGACCgcttt tcaccatgaAATTATGATATATTTATGAAaaacagaaaaggggatgggagaaaatgaa t" /listShort="cstA, S1084, ysfE" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2589388..2589444) /Source="Nicolas_S_feature" /locus_tag="new_2938273_2938329_c" /HighExp="BC, Sw, M40t90, T1.30H, M0t90, T1.0H, T0.30H, Lbstat, T2.30H, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1085" downshifts complement(2589412) /Source="Nicolas_upshifts" /id="D1471" /incds=0 /nref=12 /ntot=40 /MaxReadThrough="0.655710000000001" /MaxDrop="5.03461" /score="9.68754272" /energy="-10.5" /TU="NA" /idTUdmin="U2224" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(2589445..2590947) /gene="abfA" /locus_tag="BSU_28720" /old_locus_tag="BSU28720" /EC_number="3.2.1.55" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10417639, 11418559, 12777810, 14973026, 16233670, 18757805" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10417639, 11418559, 12777810, 14973026, 16233670, 18757805; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="alpha-L-arabinofuranosidase" /protein_id="NP_390750.2" /db_xref="EnsemblGenomes-Gn:BSU28720" /db_xref="EnsemblGenomes-Tr:CAB14832" /db_xref="GOA:P94531" /db_xref="InterPro:IPR010720" /db_xref="InterPro:IPR017853" /db_xref="SubtiList:BG11900" /db_xref="UniProtKB/Swiss-Prot:P94531" /translation="MKKARMIVDKEYKIGEVDKRIYGSFIEHMGRAVYEGIYEPDHPE ADEDGFRKDVQSLIKELQVPIIRYPGGNFLSGYNWEDGVGPVENRPRRLDLAWQTTET NEVGTNEFLSWAKKVNTEVNMAVNLGTRGIDAARNLVEYCNHPKGSYWSDLRRSHGYE QPYGIKTWCLGNEMDGPWQIGHKTADEYGRLAAETAKVMKWVDPSIELVACGSSNSGM PTFIDWEAKVLEHTYEHVDYISLHTYYGNRDNNLPNYLARSMDLDHFIKSVAATCDYV KAKTRSKKTINLSLDEWNVWYHSNEADKKVEPWITARPILEDIYNFEDALLVGSLLIT MLQHADRVKIACLAQLVNVIAPIMTEKGGEAWRQPIFYPYMHASVYGRGESLKPLISS PKYDCSDFTDVPYVDAAVVYSEEEETLTIFAVNKAEDQMETEISLRGFESYQIAEHIV LEHQDIKATNQHNRKNVVPHSNGSSSVSENGLTAHFTPLSWNVIRLKKQS*" /label="abfA CDS" gene complement(2589445..2590947) /gene="abfA" /locus_tag="BSU_28720" /old_locus_tag="BSU28720" /label="abfA gene" downshifts complement(2590818) /Source="Nicolas_upshifts" /id="D1472" /incds=1 /nref=7 /ntot=15 /MaxReadThrough="3.81491" /MaxDrop="6.33773" /score="2.73497974" /energy="-14.2" /TU="U2224,U2225" /idTUdmin="U2224" /TUdmin="-1408" /isTUend="FALSE" /label="downshifts" promotor_no_box complement(2590922..2591022) /Source="Nicolas_upshift_promotors" /id="U2224" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.608391608391608" /psig="0.017982017982018" /xcortree=1474 /SigmaFactorBS="ttgtttttccaaaagtactttatctccggcctgacggtaggg ggagtcaaaggttaatgaaggaggaaacgtgtgatgaaaaaagcgcgaatgattgtag a" /listShort="abfA" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(2590962) /Source="Nicolas_upshifts" /id="U2224" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.608391608391608" /psig="0.017982017982018" /xcortree=1474 /SigmaFactorBS="ttgtttttccaaaagtactttatctccggcctgacggtaggg ggagtcaaaggttaatgaaggaggaaacgtgtgatgaaaaaagcgcgaatgattgtag a" /listShort="abfA" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2590966..2591811) /gene="araQ" /locus_tag="BSU_28730" /old_locus_tag="BSU28730" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9084180, 10417639, 11418559, 14973026, 15849754, 16850406, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9084180, 10417639, 11418559, 14973026, 15849754, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="arabinose/arabinan permease" /protein_id="NP_390751.2" /db_xref="EnsemblGenomes-Gn:BSU28730" /db_xref="EnsemblGenomes-Tr:CAB14833" /db_xref="GOA:P94530" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11912" /db_xref="UniProtKB/Swiss-Prot:P94530" /translation="MLRHSPQFSVYRIALTLFFMMLSLLYLFPIFCLLLGSLKPSSEL LRVGLNLDIDPKVMSFDNYTFLFNGGSIYFKWFFNSLVLGLFTTVLTLFFSSMIGYGL AVYDFKGRNIIFVLVLIIMMVPLEVMMLPLFKLTVGLHLIDSYTGVILPFIVSPVAVF FFRQYALGLPRDLLDSARMDGCTEFGIFFRIMAPLMKPAFGAMIILQSLNSWNNFLWP LIVLRSKEMFTLPIGLSSLLSPYGNNYDMLISGSVFAILPVIIIFLFFQKYFISGLTV GGVKG*" /label="araQ CDS" gene complement(2590966..2591811) /gene="araQ" /locus_tag="BSU_28730" /old_locus_tag="BSU28730" /label="araQ gene" CDS complement(2591812..2592753) /gene="araP" /locus_tag="BSU_28740" /old_locus_tag="BSU28740" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9084180, 10417639, 11418559, 14973026, 15849754, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="arabinose/arabinan permease" /protein_id="NP_390752.1" /db_xref="EnsemblGenomes-Gn:BSU28740" /db_xref="EnsemblGenomes-Tr:CAB14834" /db_xref="GOA:P94529" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035277" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11911" /db_xref="UniProtKB/Swiss-Prot:P94529" /translation="MKPVKTGTVHPVPSAAKQSGWRDLFYSKKAAPYLFTAPFVLSFL VFFLYPIISVFIMSFQRILPGEVSFVGLSNYTALNNPTFYTALWNTLEYTFWTLIVLI PVPLLLAIFLNSKLVKFRNIFKSALFIPALTSTIVAGIIFRLIFGEMETSLANSILLK LGFSPQNWMNNEHTGMFLMVLLASWRWMGINILYFLAGLQNVPKELYEAADIDGANTM KKFLHITLPFLKPVTVYVLTISIIGGFRMFEESYVLWQNNSPGNIGLTLVGYLYQQGL AYNEMGYGAAIGIVLLIVILVVSLISLKLSGSFKGEG*" /label="araP CDS" gene complement(2591812..2592753) /gene="araP" /locus_tag="BSU_28740" /old_locus_tag="BSU28740" /label="araP gene" CDS complement(2592789..2594090) /gene="araN" /locus_tag="BSU_28750" /old_locus_tag="BSU28750" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9084180, 10417639, 11418559, 14973026, 15849754, 16850406, 22720735; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="sugar-binding lipoprotein" /protein_id="NP_390753.2" /db_xref="EnsemblGenomes-Gn:BSU28750" /db_xref="EnsemblGenomes-Tr:CAB14835" /db_xref="GOA:P94528" /db_xref="InterPro:IPR006059" /db_xref="SubtiList:BG11910" /db_xref="UniProtKB/Swiss-Prot:P94528" /translation="MKKMTVCFLVLMMLLTLVIAGCSAEKSSGKSGETELTFWTFNGL HEQFYVEMVKEWNKKYPDRKIKLNTVVYPYGQMHDNLSISLIAGEGVPDIADVELARF SNFLKGSDIPLADLTPLIEKDRDKFVEARLTLYSKNGKLYGLDTHVGTTVMFYNMDVM KKAGVNPDDIKTWDDYHKAGQKVRKVTGKPMGTVETNDSATFLSMISQQNSGYFDKNG KLILNNDTNVKTLQYLKDMINDKTMIPAPGGGHHSEEYYGFMNQGGAASVLMPIWYMG RFIDYMPDLKGKIAIRPLPAWKEGGDRSAGLGGTATVVPKQSKHVELAKEFLAFAKGS EEGNKKLWSVLGFDPLRWDVWSSKELKEKNKYTDYFQNGTGIFSVLLDIKDEINPIYL HEDFAKASDLVNRSVLFDALKSQQKTPKQALDRAAGELKQK*" /label="araN CDS" gene complement(2592789..2594090) /gene="araN" /locus_tag="BSU_28750" /old_locus_tag="BSU28750" /label="araN gene" CDS complement(2594121..2595305) /gene="egsA" /locus_tag="BSU_28760" /old_locus_tag="BSU28760" /EC_number="1.1.1.261" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9084180, 9973362, 10417639, 11418559, 14973026, 18558723, 22720735, 27774041" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9084180, 9973362, 10417639, 11418559, 14973026, 18558723, 22720735, 27774041; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sn-glycerol-1-phosphate dehydrogenase [NAD+] (catabolic)" /protein_id="NP_390754.1" /db_xref="EnsemblGenomes-Gn:BSU28760" /db_xref="EnsemblGenomes-Tr:CAB14836" /db_xref="GOA:P94527" /db_xref="InterPro:IPR023003" /db_xref="InterPro:IPR032837" /db_xref="SubtiList:BG11909" /db_xref="UniProtKB/Swiss-Prot:P94527" /translation="MNRIAADVQRAFENAGEKTLPIKVEEIVLGKQAADSLLDYVKRK NNQHIVLVCDANTHRIAGIDLENRLNQEGFQAECLIIPENEAGDVTADERSLIHVLIH TKQPTDVMIAVGSGTIHDIVRFAAFQRDLPFISYPTAPSVDGFTSAGAPIILYGTKTT IQTKAPSALFADLDLLKAAPQSMVAAGFGDMLGKITSLADWEISRHLAGEPYSPAGAK IVQEALAACIEHTEDIAMKTETGIRVLMESLLVSGLVMLALDHSRPASGGEHHISHWI EMELMEKKRPQILHGAKVGCAAVLLTDTYRKLAQDDGLNEFSPSRREAIQSAYQTLPR GEVLADWLRSAGGPAYFDEIGVGQDSVKNAFRHAHTLRDRCTGLRIINENKTLINHGL YE*" /label="egsA CDS" gene complement(2594121..2595305) /gene="egsA" /locus_tag="BSU_28760" /old_locus_tag="BSU28760" /label="egsA gene" CDS complement(2595302..2596120) /gene="araL" /locus_tag="BSU_28770" /old_locus_tag="BSU28770" /EC_number="3.1.3.23" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10417639, 11418559, 14973026, 21575135, 22720735, 25848029" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10417639, 11418559, 14973026, 21575135, 22720735, 25848029; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="glycolytic and pentose phosphate intermediates phosphatase" /protein_id="NP_390755.1" /db_xref="EnsemblGenomes-Gn:BSU28770" /db_xref="EnsemblGenomes-Tr:CAB14837" /db_xref="GOA:P94526" /db_xref="InterPro:IPR006357" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG11908" /db_xref="UniProtKB/Swiss-Prot:P94526" /translation="MRIMASHDTPVSPAGILIDLDGTVFRGNELIEGAREAIKTLRRM GKKIVFLSNRGNISRAMCRKKLLGAGIETDVNDIVLSSSVTAAFLKKHYRFSKVWVLG EQGLVDELRLAGVQNASEPKEADWLVISLHETLTYDDLNQAFQAAAGGARIIATNKDR SFPNEDGNAIDVAGMIGAIETSAQAKTELVVGKPSWLMAEAACTAMGLSAHECMIIGD SIESDIAMGKLYGMKSALVLTGSAKQGEQRLYTPDYVLDSIKDVTKLAEEGILI*" /label="araL CDS" gene complement(2595302..2596120) /gene="araL" /locus_tag="BSU_28770" /old_locus_tag="BSU28770" /label="araL gene" CDS complement(2596098..2596787) /gene="araD" /locus_tag="BSU_28780" /old_locus_tag="BSU28780" /EC_number="5.1.3.4" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10417639, 11418559, 11732895, 14973026, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-ribulose-5-phosphate 4-epimerase" /protein_id="NP_390756.1" /db_xref="EnsemblGenomes-Gn:BSU28780" /db_xref="EnsemblGenomes-Tr:CAB14838" /db_xref="GOA:P94525" /db_xref="InterPro:IPR001303" /db_xref="InterPro:IPR004661" /db_xref="InterPro:IPR036409" /db_xref="SubtiList:BG11906" /db_xref="UniProtKB/Swiss-Prot:P94525" /translation="MLETLKKEVLAANLKLQEHQLVTFTWGNVSGIDREKERIVIKPS GVEYSDLTADDLVVLNLDGEVVEGSLKPSSDTPTHVYLYKAFPNIGGIVHTHSQWATS WAQSGRDIPPLGTTHADYFDSAIPCTREMYDEEIIHDYELNTGKVIAETFQHHNYEQV PGVLVNNHGPFCWGTDALNAIHNAVVLETVAEMAYHSIMLNKDVTPINTVLHEKHFYR KHGANAYYGQS*" /label="araD CDS" gene complement(2596098..2596787) /gene="araD" /locus_tag="BSU_28780" /old_locus_tag="BSU28780" /label="araD gene" CDS complement(2596804..2598486) /gene="araB" /locus_tag="BSU_28790" /old_locus_tag="BSU28790" /EC_number="2.7.1.16" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 173711, 4910050, 10417639, 11418559, 14973026, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-ribulokinase" /protein_id="NP_390757.1" /db_xref="EnsemblGenomes-Gn:BSU28790" /db_xref="EnsemblGenomes-Tr:CAB14839" /db_xref="GOA:P94524" /db_xref="InterPro:IPR000577" /db_xref="InterPro:IPR005929" /db_xref="InterPro:IPR018483" /db_xref="InterPro:IPR018484" /db_xref="InterPro:IPR018485" /db_xref="SubtiList:BG11905" /db_xref="UniProtKB/Swiss-Prot:P94524" /translation="MAYTIGVDFGTLSGRAVLVHVQTGEELAAAVKEYRHAVIDTVLP KTGQKLPRDWALQHPADYLEVLETTIPSLLEQTGVDPKDIIGIGIDFTACTILPIDSS GQPLCMLPEYEEEPHSYVKLWKHHAAQKHADRLNQIAEEEGEAFLQRYGGKISSEWMI PKVMQIAEEAPHIYEAADRIIEAADWIVYQLCGSLKRSNCTAGYKAMWSEKAGYPSDD FFEKLNPSMKTITKDKLSGSIHSVGEKAGSLTEKMAKLTGLLPGTAVAVANVDAHVSV PAVGITEPGKMLMIMGTSTCHVLLGEEVHIVPGMCGVVDNGILPGYAGYEAGQSCVGD HFDWFVKTCVPPAYQEEAKEKNIGVHELLSEKANHQAPGESGLLALDWWNGNRSTLVD ADLTGMLLGMTLLTKPEEIYRALVEATAYGTRMIIETFKESGVPIEELFAAGGIAEKN PFVMQIYADVTNMDIKISGSPQAPALGSAIFGALAAGKEKGGYDDIKKAAANMGKLKD ITYTPNAENAAVYEKLYAEYKELVHYFGKENHVMKRLKTIKNLQFSSAAKKN*" /label="araB CDS" gene complement(2596804..2598486) /gene="araB" /locus_tag="BSU_28790" /old_locus_tag="BSU28790" /label="araB gene" CDS complement(2598500..2599990) /gene="araA" /locus_tag="BSU_28800" /old_locus_tag="BSU28800" /EC_number="5.3.1.4" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10417639, 10669396, 11418559, 14973026, 18263741" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10417639, 10669396, 11418559, 14973026, 18263741; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-arabinose isomerase" /protein_id="NP_390758.2" /db_xref="EnsemblGenomes-Gn:BSU28800" /db_xref="EnsemblGenomes-Tr:CAB14840" /db_xref="GOA:P94523" /db_xref="InterPro:IPR003762" /db_xref="InterPro:IPR004216" /db_xref="InterPro:IPR009015" /db_xref="InterPro:IPR024664" /db_xref="SubtiList:BG11904" /db_xref="UniProtKB/Swiss-Prot:P94523" /translation="MLQTKDYEFWFVTGSQHLYGEETLELVDQHAKSICEGLSGISSR YKITHKPVVTSPETIRELLREAEYSETCAGIITWMHTFSPAKMWIEGLSSYQKPLMHL HTQYNRDIPWGTIDMDFMNSNQSAHGDREYGYINSRMGLSRKVIAGYWDDEEVKKEMS QWMDTAAALNESRHIKVARFGDNMRHVAVTDGDKVGAHIQFGWQVDGYGIGDLVEVMD RITDDEVDTLYAEYDRLYVISEETKRDEAKVASIKEQAKIELGLTAFLEQGGYTAFTT SFEVLHGMKQLPGLAVQRLMEKGYGFAGEGDWKTAALVRMMKIMAKGKRTSFMEDYTY HFEPGNEMILGSHMLEVCPTVALDQPKIEVHSLSIGGKEDPARLVFNGISGSAIQASI VDIGGRFRLVLNEVNGQEIEKDMPNLPVARVLWKPEPSLKTAAEAWILAGGAHHTCLS YELTAEQMLDWAEMAGIESVLISRDTTIHKLKHELKWNEALYRLQK*" /label="araA CDS" gene complement(2598500..2599990) /gene="araA" /locus_tag="BSU_28800" /old_locus_tag="BSU28800" /label="araA gene" promotor_-10 complement(2600083..2600102) /Source="Nicolas_upshift_promotors" /id="U2225" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.978021978021978" /psig=1 /xcortree=1574 /SigmaFactorBS="tgcccccggctttttttaaaagaaaaGATTGACAgtataata gtcaatTACTATAATAAAATTGTTCGtacaaatatttatttataggtttattttctat c" /listShort="araA, araB, araD, araL, araM, araN, araP, araQ, abfA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2600090) /Source="Nicolas_upshifts" /id="U2225" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.978021978021978" /psig=1 /xcortree=1574 /SigmaFactorBS="tgcccccggctttttttaaaagaaaaGATTGACAgtataata gtcaatTACTATAATAAAATTGTTCGtacaaatatttatttataggtttattttctat c" /listShort="araA, araB, araD, araL, araM, araN, araP, araQ, abfA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2600092..2600167) /Source="Nicolas_S_feature" /locus_tag="new_2948977_2949052_c" /HighExp="M9-stat, T1.30H, T2.0H, T2.30H, T3.0H, T4.0H, T3.30H, T1.0H, BC, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="SigA" /TUlongPSig="0.993" /label="S1086" promotor_-35 complement(2600117..2600124) /Source="Nicolas_upshift_promotors" /id="U2225" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.978021978021978" /psig=1 /xcortree=1574 /SigmaFactorBS="tgcccccggctttttttaaaagaaaaGATTGACAgtataata gtcaatTACTATAATAAAATTGTTCGtacaaatatttatttataggtttattttctat c" /listShort="araA, araB, araD, araL, araM, araN, araP, araQ, abfA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2600168..2601139) /gene="abnA" /locus_tag="BSU_28810" /old_locus_tag="BSU28810" /EC_number="3.2.1.99" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14973026, 15556708, 17827291, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14973026, 15556708, 17827291, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="arabinan-endo-1,5-alpha-L-arabinase" /protein_id="NP_390759.2" /db_xref="EnsemblGenomes-Gn:BSU28810" /db_xref="EnsemblGenomes-Tr:CAB14841" /db_xref="GOA:P94522" /db_xref="InterPro:IPR006710" /db_xref="InterPro:IPR016840" /db_xref="InterPro:IPR023296" /db_xref="PDB:1UV4" /db_xref="SubtiList:BG11901" /db_xref="UniProtKB/Swiss-Prot:P94522" /translation="MKKKKTWKRFLHFSSAALAAGLIFTSAAPAEAAFWGASNELLHD PTMIKEGSSWYALGTGLTEERGLRVLKSSDAKNWTVQKSIFTTPLSWWSNYVPNYGQN QWAPDIQYYNGKYWLYYSVSSFGSNTSAIGLASSTSISSGGWKDEGLVIRSTSSNNYN AIDPELTFDKDGNPWLAFGSFWSGIKLTKLDKSTMKPTGSLYSIAARPNNGGALEAPT LTYQNGYYYLMVSFDKCCDGVNSTYKIAYGRSKSITGPYLDKSGKSMLEGGGTILDSG NDQWKGPGGQDIVNGNILVRHAYDANDNGIPKLLINDLNWSSGWPSY*" /label="abnA CDS" gene complement(2600168..2601139) /gene="abnA" /locus_tag="BSU_28810" /old_locus_tag="BSU28810" /label="abnA gene" S_feature complement(2601140..2601268) /Source="Nicolas_S_feature" /locus_tag="new_2950025_2950153_c" /HighExp="M9-stat, BC, T2.0H, T2.30H, T3.0H, S8, T1.30H, T3.30H, M0t90, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="SigA" /TUlongPSig="0.993" /label="S1087" promotor_-10 complement(2601253..2601272) /Source="Nicolas_upshift_promotors" /id="U2226" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.504495504495505" /psig="0.995004995004995" /xcortree=359 /SigmaFactorBS="gaagaatccgcctattgaggtggattctatttttttgtCTGT acaaattacagcatAGTGACTACAATAAAGGGGAtaccgaaaatttcctgaacatgac g" /listShort="S1087, abnA, S1086, araA, araB, araD, araL, araM, araN" /listLong="araP, araQ, abfA" /label="promotor_-10" upshifts complement(2601268) /Source="Nicolas_upshifts" /id="U2226" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.504495504495505" /psig="0.995004995004995" /xcortree=359 /SigmaFactorBS="gaagaatccgcctattgaggtggattctatttttttgtCTGT acaaattacagcatAGTGACTACAATAAAGGGGAtaccgaaaatttcctgaacatgac g" /listShort="S1087, abnA, S1086, araA, araB, araD, araL, araM, araN" /listLong="araP, araQ, abfA" /label="upshifts" promotor_-35 complement(2601287..2601290) /Source="Nicolas_upshift_promotors" /id="U2226" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.504495504495505" /psig="0.995004995004995" /xcortree=359 /SigmaFactorBS="gaagaatccgcctattgaggtggattctatttttttgtCTGT acaaattacagcatAGTGACTACAATAAAGGGGAtaccgaaaatttcctgaacatgac g" /listShort="S1087, abnA, S1086, araA, araB, araD, araL, araM, araN" /listLong="araP, araQ, abfA" /label="promotor_-35" CDS complement(2601336..2602421) /gene="frvX" /locus_tag="BSU_28820" /old_locus_tag="BSU28820" /EC_number="3.4.11.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15375159, 16021622; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative fructose-lysine aminopeptidase" /protein_id="NP_390760.1" /db_xref="EnsemblGenomes-Gn:BSU28820" /db_xref="EnsemblGenomes-Tr:CAB14842" /db_xref="GOA:P94521" /db_xref="InterPro:IPR008007" /db_xref="InterPro:IPR023367" /db_xref="PDB:1VHE" /db_xref="SubtiList:BG12317" /db_xref="UniProtKB/Swiss-Prot:P94521" /translation="MAKLDETLTMLKDLTDAKGIPGNEREVRQVMKSYIEPFADEVTT DRLGSLIAKKTGAENGPKIMIAGHLDEVGFMVTQITDKGFIRFQTVGGWWAQVMLAQR VTIVTKKGEITGVIGSKPPHILSPEARKKSVEIKDMFIDIGASSREEALEWGVLPGDM IVPHFEFTVMNNEKFLLAKAWDNRIGCAIAIDVLRNLQNTDHPNIVYGVGTVQEEVGL RGAKTAAHTIQPDIAFGVDVGIAGDTPGISEKEAQSKMGKGPQIIVYDASMVSHKGLR DAVVATAEEAGIPYQFDAIAGGGTDSGAIHLTANGVPALSITIATRYIHTHAAMLHRD DYENAVKLITEVIKKLDRKTVDEITYQ*" /label="frvX CDS" gene complement(2601336..2602421) /gene="frvX" /locus_tag="BSU_28820" /old_locus_tag="BSU28820" /label="frvX gene" downshifts complement(2601350) /Source="Nicolas_upshifts" /id="D1473" /incds=0 /nref=233 /ntot=262 /MaxReadThrough="3.55686" /MaxDrop="6.91328" /score="-0.475558157" /energy="-9.9" /TU="U2227" /idTUdmin="U2227" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2602447..2602466) /Source="Nicolas_upshift_promotors" /id="U2227" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.97902097902098" /psig="0.993006993006993" /xcortree=2217 /SigmaFactorBS="aaaagaaagctgtaaaaacatatacccgattttcaagtgaaa TAGTCGTAtggttagcgccatgTTTTGTATAATAAGAATGCAggactgatgaaggagg g" /listShort="ysdC" /listLong="S1087, abnA, S1086, araA, araB, araD, araL, araM, araN, araP, araQ, abfA" /label="promotor_-10" upshifts complement(2602470) /Source="Nicolas_upshifts" /id="U2227" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.97902097902098" /psig="0.993006993006993" /xcortree=2217 /SigmaFactorBS="aaaagaaagctgtaaaaacatatacccgattttcaagtgaaa TAGTCGTAtggttagcgccatgTTTTGTATAATAAGAATGCAggactgatgaaggagg g" /listShort="ysdC" /listLong="S1087, abnA, S1086, araA, araB, araD, araL, araM, araN, araP, araQ, abfA" /label="upshifts" promotor_-35 complement(2602481..2602488) /Source="Nicolas_upshift_promotors" /id="U2227" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.97902097902098" /psig="0.993006993006993" /xcortree=2217 /SigmaFactorBS="aaaagaaagctgtaaaaacatatacccgattttcaagtgaaa TAGTCGTAtggttagcgccatgTTTTGTATAATAAGAATGCAggactgatgaaggagg g" /listShort="ysdC" /listLong="S1087, abnA, S1086, araA, araB, araD, araL, araM, araN, araP, araQ, abfA" /label="promotor_-35" promotor_-35 2602539..2602548 /Source="Nicolas_upshift_promotors" /id="U2228" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1686 /SigmaFactorBS="cttgaaaatcgggtatatgtttttacagctttcttttagaaa aagTGAAACCTTTttctatgctttTCGTATTACATCAGATcatcaccataagggaggt g" /listShort="ysdB, S1088, yscB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2602554 /Source="Nicolas_upshifts" /id="U2228" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1686 /SigmaFactorBS="cttgaaaatcgggtatatgtttttacagctttcttttagaaa aagTGAAACCTTTttctatgctttTCGTATTACATCAGATcatcaccataagggaggt g" /listShort="ysdB, S1088, yscB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2602560..2602575 /Source="Nicolas_upshift_promotors" /id="U2228" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1686 /SigmaFactorBS="cttgaaaatcgggtatatgtttttacagctttcttttagaaa aagTGAAACCTTTttctatgctttTCGTATTACATCAGATcatcaccataagggaggt g" /listShort="ysdB, S1088, yscB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2602605..2602997 /gene="ysdB" /locus_tag="BSU_28830" /old_locus_tag="BSU28830" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 10960106, 23155385" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390761.1" /db_xref="EnsemblGenomes-Gn:BSU28830" /db_xref="EnsemblGenomes-Tr:CAB14843" /db_xref="GOA:P94520" /db_xref="SubtiList:BG12316" /db_xref="UniProtKB/Swiss-Prot:P94520" /translation="MFVMVLRIILLALFAYCIYAVVKYVANPKRRLKLAQSKEHFYII DEQNNTRKNFQLTYKGVLFEGEKHIPSKDHPLFIHTIFVWTESPEKLKHFSAKDFENI EEKVLERYPNCKIDWDQPIKLAKKAEER*" /label="ysdB CDS" gene 2602605..2602997 /gene="ysdB" /locus_tag="BSU_28830" /old_locus_tag="BSU28830" /label="ysdB gene" downshifts 2602968 /Source="Nicolas_upshifts" /id="D1474" /incds=0 /nref=86 /ntot=229 /MaxReadThrough="5.09744" /MaxDrop="4.57118" /score="13.4996084" /energy="-15.8" /TU="U2228" /idTUdmin="U2228" /TUdmin="-2112" /isTUend="FALSE" /label="downshifts" S_feature 2603013..2603319 /Source="Nicolas_S_feature" /locus_tag="new_2951898_2952204" /HighExp="Etha, M9-stat, T0.30H, T1.30H, T1.0H, T2.0H, T2.30H, S8, T3.30H, Salt" /AntisenseName="ysdA" /AntisenseCor="-0.31305612685159701" /AntisenseRegPval="-6.8" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1088" CDS complement(2603013..2603282) /gene="ysdA" /locus_tag="BSU_28840" /old_locus_tag="BSU28840" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17289755; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane component" /protein_id="NP_390762.1" /db_xref="EnsemblGenomes-Gn:BSU28840" /db_xref="EnsemblGenomes-Tr:CAB14844" /db_xref="GOA:P94519" /db_xref="InterPro:IPR010718" /db_xref="SubtiList:BG12315" /db_xref="UniProtKB/Swiss-Prot:P94519" /translation="MIIAAYLVLINLCGFWVMGIDKRKAQQHKWRISEDRLWLIAIVF GALGVWLGMQTFRHKTKHASFKYGVPLLLVIEAILIAIYYSPFDL*" /label="ysdA CDS" gene complement(2603013..2603282) /gene="ysdA" /locus_tag="BSU_28840" /old_locus_tag="BSU28840" /label="ysdA gene" downshifts complement(2603029) /Source="Nicolas_upshifts" /id="D1475" /incds=0 /nref=6 /ntot=206 /MaxReadThrough="2.53274" /MaxDrop="3.80421" /score="20.1281719" /energy="-14" /TU="U2229" /idTUdmin="U2230" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" downshifts complement(2603198) /Source="Nicolas_upshifts" /id="D1476" /incds=1 /nref=1 /ntot=37 /MaxReadThrough="4.90568" /MaxDrop="2.19601" /score="25.5196116" /energy="-14.1" /TU="U2229,U2230" /idTUdmin="U2230" /TUdmin="-176" /isTUend="FALSE" /label="downshifts" downshifts 2603276 /Source="Nicolas_upshifts" /id="D1477" /incds=0 /nref=8 /ntot=135 /MaxReadThrough="4.08794" /MaxDrop="3.37039" /score="13.4996084" /energy="-15.8" /TU="U2228" /idTUdmin="U2228" /TUdmin="-1804" /isTUend="FALSE" /label="downshifts" CDS complement(2603339..2603698) /gene="rplT" /locus_tag="BSU_28850" /old_locus_tag="BSU28850" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12682299, 17289755, 21843271, 23611891" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17289755, 21843271, 23611891; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L20" /protein_id="NP_390763.1" /db_xref="EnsemblGenomes-Gn:BSU28850" /db_xref="EnsemblGenomes-Tr:CAB14845" /db_xref="GOA:P55873" /db_xref="InterPro:IPR005813" /db_xref="InterPro:IPR035566" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11971" /db_xref="UniProtKB/Swiss-Prot:P55873" /translation="MPRVKGGTVTRKRRKKVLKLAKGYFGSKHTLYKVANQQVMKSGN YAFRDRRQKKRDFRKLWITRINAAARMNGLSYSRLMHGLKLSGIEVNRKMLADLAVND LTAFNQLADAAKAQLNK*" /label="rplT CDS" gene complement(2603339..2603698) /gene="rplT" /locus_tag="BSU_28850" /old_locus_tag="BSU28850" /label="rplT gene" downshifts complement(2603352) /Source="Nicolas_upshifts" /id="D1478" /incds=0 /nref=260 /ntot=268 /MaxReadThrough="5.94351" /MaxDrop="6.27682" /score="25.5196116" /energy="-14.1" /TU="U2229,U2230" /idTUdmin="U2230" /TUdmin="-330" /isTUend="FALSE" /label="downshifts" CDS complement(2603730..2603930) /gene="rpmI" /locus_tag="BSU_28860" /old_locus_tag="BSU28860" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8722036, 12682299, 17289755, 21843271, 23002217, 23611891, 24335279" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8722036, 12682299, 17289755, 21843271, 23002217, 23611891, 24335279; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L35" /protein_id="NP_390764.1" /db_xref="EnsemblGenomes-Gn:BSU28860" /db_xref="EnsemblGenomes-Tr:CAB14846" /db_xref="GOA:P55874" /db_xref="InterPro:IPR001706" /db_xref="InterPro:IPR018265" /db_xref="InterPro:IPR021137" /db_xref="InterPro:IPR037229" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG11972" /db_xref="UniProtKB/Swiss-Prot:P55874" /translation="MPKMKTHRGSAKRFKKTGSGKLKRSHAYTSHLFANKSQKQKRKL RKSAVVSAGDFKRIKQMLANIK*" /label="rpmI CDS" gene complement(2603730..2603930) /gene="rpmI" /locus_tag="BSU_28860" /old_locus_tag="BSU28860" /label="rpmI gene" CDS complement(2603943..2604464) /gene="infC" /locus_tag="BSU_28870" /old_locus_tag="BSU28870" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 17289755, 21843271, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17289755, 21843271, 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="initiation factor IF-3" /protein_id="NP_390765.1" /db_xref="EnsemblGenomes-Gn:BSU28870" /db_xref="EnsemblGenomes-Tr:CAB14847" /db_xref="GOA:P55872" /db_xref="InterPro:IPR001288" /db_xref="InterPro:IPR019813" /db_xref="InterPro:IPR019814" /db_xref="InterPro:IPR019815" /db_xref="InterPro:IPR036787" /db_xref="InterPro:IPR036788" /db_xref="SubtiList:BG11944" /db_xref="UniProtKB/Swiss-Prot:P55872" /translation="MISKDQLVNEGIRAREVRLIGQNGDQLGIKSRQEALEIAGRANL DLVLVAANAKPPVCRIMDYGKFRFEQQKKEKEARKNQKIINLKEVRLSPTIDEHDFNT KLRNAIKFLEKGDKVKASIRFKGRAITHKEIGQRVLDRFSEACAEVATVETKPKMDGR SMFLMLAPKNEKQ*" /label="infC CDS" gene complement(2603943..2604464) /gene="infC" /locus_tag="BSU_28870" /old_locus_tag="BSU28870" /label="infC gene" misc_RNA complement(2604526..2604665) /locus_tag="BSU_misc_RNA_47" /product="mRNA L20_leader attenuator sequence" /experiment="publication(s) with functional evidences, PMID:17289755, 23611891" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17289755, 23611891" /label="mRNA L20 leader attenuator sequence" gene complement(2604526..2604665) /locus_tag="BSU_misc_RNA_47" /label="gene" promotor_-10 complement(2604662..2604681) /Source="Nicolas_upshift_promotors" /id="U2229" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.768231768231768" /psig=1 /xcortree=2647 /SigmaFactorBS="caatgtaaaagttgttccggataagtcgtcCTTGACTAaaga tccggtattGTGTAGAATAGTTATTGAATtgaatataaatcacaagcagaagcacccg c" /listShort="NA, infC, rpmI, rplT, ysdA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2604672) /Source="Nicolas_upshifts" /id="U2229" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.768231768231768" /psig=1 /xcortree=2647 /SigmaFactorBS="caatgtaaaagttgttccggataagtcgtcCTTGACTAaaga tccggtattGTGTAGAATAGTTATTGAATtgaatataaatcacaagcagaagcacccg c" /listShort="NA, infC, rpmI, rplT, ysdA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2604674..2604738) /Source="Nicolas_S_feature" /locus_tag="new_2953559_2953623_c" /HighExp="Paraq, G180, G150, G135, H2O2, LPh, C30, Oxctl, LBGexp, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1089" promotor_-35 complement(2604695..2604702) /Source="Nicolas_upshift_promotors" /id="U2229" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.768231768231768" /psig=1 /xcortree=2647 /SigmaFactorBS="caatgtaaaagttgttccggataagtcgtcCTTGACTAaaga tccggtattGTGTAGAATAGTTATTGAATtgaatataaatcacaagcagaagcacccg c" /listShort="NA, infC, rpmI, rplT, ysdA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2604720..2604739) /Source="Nicolas_upshift_promotors" /id="U2230" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.966033966033966" /psig=1 /xcortree=2590 /SigmaFactorBS="tttgtattctgggtggggatgaaagattttctttttctcTCT TGcgctcatagaaaaccCATGTTACAATGTAAAAGTTgttccggataagtcgtccttg a" /listShort="S1089, NA, infC, rpmI, rplT, ysdA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2604738) /Source="Nicolas_upshifts" /id="U2230" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.966033966033966" /psig=1 /xcortree=2590 /SigmaFactorBS="tttgtattctgggtggggatgaaagattttctttttctcTCT TGcgctcatagaaaaccCATGTTACAATGTAAAAGTTgttccggataagtcgtccttg a" /listShort="S1089, NA, infC, rpmI, rplT, ysdA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2604755..2604759) /Source="Nicolas_upshift_promotors" /id="U2230" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.966033966033966" /psig=1 /xcortree=2590 /SigmaFactorBS="tttgtattctgggtggggatgaaagattttctttttctcTCT TGcgctcatagaaaaccCATGTTACAATGTAAAAGTTgttccggataagtcgtccttg a" /listShort="S1089, NA, infC, rpmI, rplT, ysdA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2604857..2604864 /Source="Nicolas_upshift_promotors" /id="U2231" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2840 /SigmaFactorBS="attacgcaatttacaacaaaaccaccgacaggaagaaatGTA AAACAaagttaatctctgACCGATATAAGGAGCAGAAgggagcctgacacatgaacaa a" /listShort="yscB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2604878..2604896 /Source="Nicolas_upshift_promotors" /id="U2231" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2840 /SigmaFactorBS="attacgcaatttacaacaaaaccaccgacaggaagaaatGTA AAACAaagttaatctctgACCGATATAAGGAGCAGAAgggagcctgacacatgaacaa a" /listShort="yscB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2604878 /Source="Nicolas_upshifts" /id="U2231" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2840 /SigmaFactorBS="attacgcaatttacaacaaaaccaccgacaggaagaaatGTA AAACAaagttaatctctgACCGATATAAGGAGCAGAAgggagcctgacacatgaacaa a" /listShort="yscB" /GFF_Attribute="listLong" /label="upshifts" CDS 2604910..2605575 /gene="yscB" /locus_tag="BSU_28890" /old_locus_tag="BSU28890" /function="14: Cell envelope" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15033535; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_390767.2" /db_xref="EnsemblGenomes-Gn:BSU28890" /db_xref="EnsemblGenomes-Tr:CAB14849" /db_xref="SubtiList:BG12314" /db_xref="UniProtKB/Swiss-Prot:P94517" /translation="MNKLIQLALFFTLMLTGCSNSSTSSESKVETTVKTTAAFPQKEL EKELKKLKPVSLDMKFESPLATELGKRKAKEEAEKQRQIAAEKKLEKEREAKRKKQQE EKAERQRLAEQQAAERQRLAEAERQAELERQRQAAIQKEQKANAEKKRQSQAQRQQTE APSSNSQDPPSSSSQTDKTIQQPASELPDDDGYGYEERKKWHDDQVEWGIKQGYIDPE DAP*" /label="yscB CDS" gene 2604910..2605575 /gene="yscB" /locus_tag="BSU_28890" /old_locus_tag="BSU28890" /label="yscB gene" downshifts 2605553 /Source="Nicolas_upshifts" /id="D1479" /incds=0 /nref=27 /ntot=178 /MaxReadThrough="2.51181" /MaxDrop="3.43861" /score="13.4996084" /energy="-15.8" /TU="NA" /idTUdmin="U2231" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2605607..2606302) /gene="pftB" /locus_tag="BSU_28900" /old_locus_tag="BSU28900" /function="16.5: Explore" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15126464, 15849754, 16850406, 17452642, 26060272, 26406329, 28974613" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15126464, 15849754, 16850406, 17452642, 26060272, 26406329, 28974613; Product type t: transporter" /codon_start=1 /transl_table=11 /product="pyruvate import system subunit B" /protein_id="NP_390768.1" /db_xref="EnsemblGenomes-Gn:BSU28900" /db_xref="EnsemblGenomes-Tr:CAB14850" /db_xref="GOA:P94516" /db_xref="InterPro:IPR007300" /db_xref="InterPro:IPR024891" /db_xref="SubtiList:BG12312" /db_xref="UniProtKB/Swiss-Prot:P94516" /translation="MESTMSPYFGIVVSLAAFGIGTFLFKKTKGFFLFTPLFVAMVLG IAFLKIGGFSYADYNNGGEIIKFFLEPATIAFAIPLYKQRDKLKKYWWQIMASIIAGS ICSVTIVYLLAKGIHLDSAVMKSMLPQAATTAIALPLSKGIGGISDITAFAVIFNAVI VYALGALFLKVFKVKNPISKGLALGTSGHALGVAVGIEMGEVEAAMASIAVVVVGVVT VLVIPVFVQLIGG*" /label="pftB CDS" gene complement(2605607..2606302) /gene="pftB" /locus_tag="BSU_28900" /old_locus_tag="BSU28900" /label="pftB gene" downshifts complement(2605629) /Source="Nicolas_upshifts" /id="D1480" /incds=0 /nref=19 /ntot=45 /MaxReadThrough="1.25312" /MaxDrop="6.13174" /score="49.3872074" /energy="-13.7" /TU="NA" /idTUdmin="U2232" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(2605673) /Source="Nicolas_upshifts" /id="D1481" /incds=1 /nref=2 /ntot=36 /MaxReadThrough="6.79502" /MaxDrop="3.1016" /score="49.3872074" /energy="-13.7" /TU="U2232" /idTUdmin="U2232" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" CDS complement(2606324..2606764) /gene="pftA" /locus_tag="BSU_28910" /old_locus_tag="BSU28910" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:15659658, 17452642, 26060272, 27422364, 28974613" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15659658, 17452642, 26060272, 27422364, 28974613; Product type t : transporter" /codon_start=1 /transl_table=11 /product="pyruvate uptake system subunit A" /protein_id="NP_390769.1" /db_xref="EnsemblGenomes-Gn:BSU28910" /db_xref="EnsemblGenomes-Tr:CAB14851" /db_xref="GOA:P94515" /db_xref="InterPro:IPR005538" /db_xref="InterPro:IPR023736" /db_xref="SubtiList:BG12311" /db_xref="UniProtKB/Swiss-Prot:P94515" /translation="MSAKKVYGFLTQAFIFAVIMLVSNMIAAIVPIPIPASVVGLVLL FLLLCLKVIKLEQVETLGTSLTSLIGFLFVPSGISVMNSLGVMQQYGLQIVLVILLAT IILLGATGLFSQLILSLSGKRKTEADMKTKTVQSPQNNNELVHH*" /label="pftA CDS" gene complement(2606324..2606764) /gene="pftA" /locus_tag="BSU_28910" /old_locus_tag="BSU28910" /label="pftA gene" promotor_-10 complement(2606786..2606805) /Source="Nicolas_upshift_promotors" /id="U2232" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.434565434565435" /psig="0.982017982017982" /xcortree=1540 /SigmaFactorBS="ctgcaactcagacccgctatacggcatgttatcttgtaagcG CTTtataacagggaattcTTATTTATAATGAGGGTACCaaagagaaagaggtgaagaa a" /listShort="lrgA, lrgB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2606805) /Source="Nicolas_upshifts" /id="U2232" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.434565434565435" /psig="0.982017982017982" /xcortree=1540 /SigmaFactorBS="ctgcaactcagacccgctatacggcatgttatcttgtaagcG CTTtataacagggaattcTTATTTATAATGAGGGTACCaaagagaaagaggtgaagaa a" /listShort="lrgA, lrgB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2606821..2606824) /Source="Nicolas_upshift_promotors" /id="U2232" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.434565434565435" /psig="0.982017982017982" /xcortree=1540 /SigmaFactorBS="ctgcaactcagacccgctatacggcatgttatcttgtaagcG CTTtataacagggaattcTTATTTATAATGAGGGTACCaaagagaaagaggtgaagaa a" /listShort="lrgA, lrgB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2606898..2607623) /gene="lytT" /locus_tag="BSU_28920" /old_locus_tag="BSU28920" /function="16.13: Shape" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10940023, 11717295, 12034833, 12914674, 22937869, 25491472, 27127614, 27422364, 28348880" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10940023, 11717295, 12034833, 12914674, 22937869, 25491472, 27127614, 27422364, 28348880; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [LytS]" /protein_id="NP_390770.1" /db_xref="EnsemblGenomes-Gn:BSU28920" /db_xref="EnsemblGenomes-Tr:CAB14852" /db_xref="GOA:P94514" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR007492" /db_xref="InterPro:IPR011006" /db_xref="SubtiList:BG11953" /db_xref="UniProtKB/Swiss-Prot:P94514" /translation="MLRVLIVDDEMLARDELAYLLKRTNDEMEINEAENIESAFDQMM DQKPDLLFLDVDLSGENGFDIAKRLKKMKHPPAIVFATAYDQYALKAFEVDALDYLTK PFDEERIQQTLKKYKKVNRDIVETEQNSHAGQHKLALSVGESIVIVDTKDIIYAGTED GHVNVKTFDHSYTVSDTLVVIEKKLPDSDFIRVHRSFVVNTEYIKEIQPWFNSTYNLI MKDGSKIPVSRTYAKELKKLLHI*" /label="lytT CDS" gene complement(2606898..2607623) /gene="lytT" /locus_tag="BSU_28920" /old_locus_tag="BSU28920" /label="lytT gene" downshifts complement(2606927) /Source="Nicolas_upshifts" /id="D1482" /incds=0 /nref=231 /ntot=256 /MaxReadThrough="-0.0173499999999995" /MaxDrop="6.64673" /score="-8.47161605" /energy="-8.9" /TU="NA" /idTUdmin="U2232" /TUdmin="-1298" /isTUend="FALSE" /label="downshifts" CDS complement(2607601..2609382) /gene="lytS" /locus_tag="BSU_28930" /old_locus_tag="BSU28930" /function="16.3: Control" /function="16.13: Shape" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:10940023, 11717295, 12034833, 12914674, 22937869, 25491472, 27127614, 27422364, 28348880" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10940023, 11717295, 12034833, 12914674, 22937869, 25491472, 27127614, 27422364, 28348880; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [LytT]" /protein_id="NP_390771.1" /db_xref="EnsemblGenomes-Gn:BSU28930" /db_xref="EnsemblGenomes-Tr:CAB14853" /db_xref="GOA:P94513" /db_xref="InterPro:IPR003018" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR010559" /db_xref="InterPro:IPR011620" /db_xref="InterPro:IPR029016" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG11952" /db_xref="UniProtKB/Swiss-Prot:P94513" /translation="MIHLMIMMLERVGIIVILGFILAHTKLFRQALQNQDGYKGKAIL ISIFSLFSIISNYTGIEIQRNMIVNNDWVFTIDPSGSIANTRILGVEIGGLLGGPFVG AGIGILAGLHRFSLGGSTALSCAVSSILAGVLAGLIGRYFTKRYRMPTPRIAALVGIG MESLQMIIILLMAKPFSDAWELVSMIGIPMILINGTGSFIFLSIIQAIIRKEEQARAL ETHRVLTIADQTLPFFRQGLNENSCKSVAAIIHKLTGTDAVSLTDKEKILAHVGAGMD HHIPSKSLITGLSKKVIKTGHIMKAISQEEIECTHAECPLHAAIVLPLTSNGNTIGTL KMYFKSPAGLSQVEEELAEGLAMLFSTQLELGEAELQSKLLKDAEIKALQAQVNPHFL FNAINTISALCRTDVEKTRKLLLQLSVYFRSNLQGARQLLIPLSKELNHLNAYLSLEQ ARFPGKYKIELNIDSRLEQIEIPPFVLQVLVENALRHAFPKKQDICKVTVCVLSDDAS VYMKVADNGRGIPPDVLPELGKKPFPSKEGTGTALYNLNQRLIGLFGQQAALHISSEV HKGTEVSFQVPMQQMKEGEEHAQGVNS*" /label="lytS CDS" gene complement(2607601..2609382) /gene="lytS" /locus_tag="BSU_28930" /old_locus_tag="BSU28930" /label="lytS gene" promotor_-35 2609466..2609469 /Source="Nicolas_upshift_promotors" /id="U2234" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.513486513486514" /psig="0.999000999001" /xcortree=3039 /SigmaFactorBS="cggctgactgtttttttaaaatcgtctgaaaacatATTTcac aaggcttttatCTATTGTAAAATAAAACATGagccttttggcagaaagatttgaatct g" /listShort="ysaA" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(2609478..2609497) /Source="Nicolas_upshift_promotors" /id="U2233" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.632367632367632" /psig="0.999000999001" /xcortree=3026 /SigmaFactorBS="tctcctctgcttcagattcaaatctttctgccaaaaggctca tgttTTATTTTACAATAGATAAAAgccttgtgaaatatgttttcagacgattttaaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2609483) /Source="Nicolas_upshifts" /id="U2233" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.632367632367632" /psig="0.999000999001" /xcortree=3026 /SigmaFactorBS="tctcctctgcttcagattcaaatctttctgccaaaaggctca tgttTTATTTTACAATAGATAAAAgccttgtgaaatatgttttcagacgattttaaaa a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2609484..2609503 /Source="Nicolas_upshift_promotors" /id="U2234" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.513486513486514" /psig="0.999000999001" /xcortree=3039 /SigmaFactorBS="cggctgactgtttttttaaaatcgtctgaaaacatATTTcac aaggcttttatCTATTGTAAAATAAAACATGagccttttggcagaaagatttgaatct g" /listShort="ysaA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2609491 /Source="Nicolas_upshifts" /id="U2234" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.513486513486514" /psig="0.999000999001" /xcortree=3039 /SigmaFactorBS="cggctgactgtttttttaaaatcgtctgaaaacatATTTcac aaggcttttatCTATTGTAAAATAAAACATGagccttttggcagaaagatttgaatct g" /listShort="ysaA" /GFF_Attribute="listLong" /label="upshifts" CDS 2609549..2610331 /gene="ysaA" /locus_tag="BSU_28940" /old_locus_tag="BSU28940" /EC_number="3.1.3.-" /experiment="publication(s) with functional evidences, PMID:15479782, 24123841, 25848029, 27784292" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15479782, 24123841, 25848029, 27784292; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous phosphatase" /protein_id="NP_390772.2" /db_xref="EnsemblGenomes-Gn:BSU28940" /db_xref="EnsemblGenomes-Tr:CAB14854" /db_xref="GOA:P94512" /db_xref="InterPro:IPR006439" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG12310" /db_xref="UniProtKB/Swiss-Prot:P94512" /translation="MKAVFFDLDDTLLWDEKSVRTTFAETCLQAEKKYGLAPEEFEAA VREAARELYMSYETYPYTVMIGINPFEGLWSNFSEPISEGFQKLNKIVPEYRRNAWTN GLKALGIDDPAYGEYLGEFFAAERRKRPFVYDETFAVLDQLKGKYELLLLTNGDPSLQ KEKLAGVPELAPYFNEIVISGAFGKGKPDVSIFEHCLKLMNIEKDDAIMVGDNLNTDI LGASRAGIKTVWINRTDKKNETDVKPDYIISSLHDLFPILEK*" /label="ysaA CDS" gene 2609549..2610331 /gene="ysaA" /locus_tag="BSU_28940" /old_locus_tag="BSU28940" /label="ysaA gene" downshifts 2610315 /Source="Nicolas_upshifts" /id="D1483" /incds=0 /nref=36 /ntot=265 /MaxReadThrough="1.0046" /MaxDrop="6.73727" /score="35.9560361" /energy="-13.8" /TU="NA" /idTUdmin="U2234" /TUdmin="-12" /isTUend="TRUE" /label="downshifts" downshifts complement(2610365) /Source="Nicolas_upshifts" /id="D1484" /incds=0 /nref=89 /ntot=246 /MaxReadThrough="1.13716" /MaxDrop="6.01766" /score="35.534455" /energy="-13.8" /TU="NA" /idTUdmin="U2235" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" CDS complement(2610372..2612303) /gene="thrS" /locus_tag="BSU_28950" /old_locus_tag="BSU28950" /EC_number="6.1.1.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8692931, 9826762, 10632708, 15831787, 22938038" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8692931, 9826762, 10632708, 15831787, 22938038; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="threonyl-tRNA synthetase" /protein_id="NP_390773.1" /db_xref="EnsemblGenomes-Gn:BSU28950" /db_xref="EnsemblGenomes-Tr:CAB14855" /db_xref="GOA:P18255" /db_xref="InterPro:IPR002314" /db_xref="InterPro:IPR002320" /db_xref="InterPro:IPR004095" /db_xref="InterPro:IPR004154" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR012676" /db_xref="InterPro:IPR012947" /db_xref="InterPro:IPR018163" /db_xref="InterPro:IPR033728" /db_xref="InterPro:IPR036621" /db_xref="SubtiList:BG10362" /db_xref="UniProtKB/Swiss-Prot:P18255" /translation="MSDMVKITFPDGAVKEFAKGTTTEDIAASISPGLKKKSLAGKLN GKEIDLRTPINEDGTVEIITEGSEEGLQIMRHSAAHLLAQAIKRIYKDVKFGVGPVIE NGFYYDVEMDEAITPEDLPKIEKEMKKIVNANLPIVRKEVSREEAKARFAEIGDDLKL ELLDAIPEGETVSIYEQGEFFDLCRGVHVPSTGKIKEFKLLSLAGAYWRGDSKNQMLQ RVYGTAFFKKADLEEHLRMLEEAKERDHRKLGKELKLFANSQKVGQGLPLWLPKGATI RRVIERYIVDKEISLGYEHVYTPVLGSKELYETSGHWDHYQEGMFPPMEMDNETLVLR PMNCPHHMMIYKQDIHSYRELPIRIAELGTMHRYEMSGALSGLQRVRGMTLNDAHIFV RPDQIKDEFIRTVRLIQDVYEDFGLSDYTFRLSYRDPEDTEKYFDDDEMWNKAQSMLK EAMDEIGHDYYEAEGEAAFYGPKLDVQVKTAIGKEETLSTVQLDFLLPERFDLTYIGE DGKQHRPVVIHRGVVSTMERFVAFLIEEHKGALPTWLAPVQFQVIPVSPAVHLDYAKK VQERLQCEGLRVEVDSRDEKIGYKIREAQMQKIPYMLVVGDQEAENGAVNVRKYGEQN SETISLDEFVKKAVAEAKK*" /label="thrS CDS" gene complement(2610372..2612303) /gene="thrS" /locus_tag="BSU_28950" /old_locus_tag="BSU28950" /label="thrS gene" misc_RNA complement(2612347..2612594) /gene="tboT" /locus_tag="BSU_misc_RNA_48" /product="T-box riboswitch specific of threonine tRNA ligase" /experiment="publication(s) with functional evidences, PMID:9098041, 9826762, 1317842, 12165569, 12547201" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9098041, 9826762, 1317842, 12165569, 12547201; Product type n: RNA" /function="16.3: Control" /label="tboT RNA" gene complement(2612347..2612594) /gene="tboT" /locus_tag="BSU_misc_RNA_48" /label="tboT gene" promotor_-10 complement(2612350..2612359) /Source="Nicolas_upshift_promotors" /id="U2235" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.308691308691309" /psig="0.0969030969030969" /xcortree=1774 /SigmaFactorBS="gtgtattggctttgcggaaaaaagggtggaacCacgattccg tttattcaaCCTCGTCCCTttcatagggggcggggtttttatatgcaaaaaaaggagt g" /listShort="thrS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2612350) /Source="Nicolas_upshifts" /id="U2235" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.308691308691309" /psig="0.0969030969030969" /xcortree=1774 /SigmaFactorBS="gtgtattggctttgcggaaaaaagggtggaacCacgattccg tttattcaaCCTCGTCCCTttcatagggggcggggtttttatatgcaaaaaaaggagt g" /listShort="thrS" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(2612405) /Source="Nicolas_upshifts" /id="D1485" /incds=0 /nref=1 /ntot=16 /MaxReadThrough="6.71261" /MaxDrop="3.31801" /score="19.160794" /energy="-16.2" /TU="U2236,U2237,U2238,U2241" /idTUdmin="U2239" /TUdmin=221 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2612605..2612624) /Source="Nicolas_upshift_promotors" /id="U2236" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.460539460539461" /psig=1 /xcortree=2576 /SigmaFactorBS="aggctgtcggtttaaaaaaaaggaaacgcgatcgTGTTGatt ttttggattgaaCAATTTATAATACATAGGAGattaagaaagacacacgtattgataa g" /listShort="NA, thrS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2612618) /Source="Nicolas_upshifts" /id="U2236" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.460539460539461" /psig=1 /xcortree=2576 /SigmaFactorBS="aggctgtcggtttaaaaaaaaggaaacgcgatcgTGTTGatt ttttggattgaaCAATTTATAATACATAGGAGattaagaaagacacacgtattgataa g" /listShort="NA, thrS" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2612620..2612700) /Source="Nicolas_S_feature" /locus_tag="new_2961505_2961585_c" /HighExp="S3, S4, LoTm, S5, G135, G180, LBGtran, T5.0H, G/S, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA, SigA, SigA" /TUshortPSig="1, 1, 0.998, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1090" promotor_-35 complement(2612640..2612644) /Source="Nicolas_upshift_promotors" /id="U2236" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.460539460539461" /psig=1 /xcortree=2576 /SigmaFactorBS="aggctgtcggtttaaaaaaaaggaaacgcgatcgTGTTGatt ttttggattgaaCAATTTATAATACATAGGAGattaagaaagacacacgtattgataa g" /listShort="NA, thrS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2612701..2613546) /gene="ytxC" /locus_tag="BSU_28960" /old_locus_tag="BSU28960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 22882546; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="sporulation protein" /protein_id="NP_390774.2" /db_xref="EnsemblGenomes-Gn:BSU28960" /db_xref="EnsemblGenomes-Tr:CAB14856" /db_xref="InterPro:IPR014199" /db_xref="SubtiList:BG10361" /db_xref="UniProtKB/Swiss-Prot:P06569" /translation="MLEIIFEDDHDAAAFLHLIQHSDDRNNIIVREGIRKIGIEKANP AFPIQRFMEPILVKFFLECKEDEHMLSLIEETYCFTDQDEQQQILQLAHSIIEGEADD LPFEPLKLSRKQSILDELQTICLEEGVFYIRSFQTFRLGSYYKQLRDITEAAIDEYKM EQEYQNFIQTLRDYVDAKQPRIKKVHIVHDGSFTLWELRYVPEREKMKYIDRRFVRDH PMYIDSHLLAPLISIAPDEVVLYTDQPEHMMARTIQNVFQERVEMLPLHAFTDAEIPV KHSEG*" /label="ytxC CDS" gene complement(2612701..2613546) /gene="ytxC" /locus_tag="BSU_28960" /old_locus_tag="BSU28960" /label="ytxC gene" promotor_-10 complement(2613566..2613584) /Source="Nicolas_upshift_promotors" /id="U2237" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1000 /SigmaFactorBS="caaattaagatttgccaatgacctttaCGTCTAttttaaaaa catcccCCATATACTTGTAACAGATgccgtaaggggggacaaacatgcttgaaataat c" /listShort="ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2613572) /Source="Nicolas_upshifts" /id="U2237" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1000 /SigmaFactorBS="caaattaagatttgccaatgacctttaCGTCTAttttaaaaa catcccCCATATACTTGTAACAGATgccgtaaggggggacaaacatgcttgaaataat c" /listShort="ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2613600..2613605) /Source="Nicolas_upshift_promotors" /id="U2237" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1000 /SigmaFactorBS="caaattaagatttgccaatgacctttaCGTCTAttttaaaaa catcccCCATATACTTGTAACAGATgccgtaaggggggacaaacatgcttgaaataat c" /listShort="ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2613625..2614266) /gene="ytxB" /locus_tag="BSU_28970" /old_locus_tag="BSU28970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 25728272, 27190159; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative osomosensing transporter" /protein_id="NP_390775.1" /db_xref="EnsemblGenomes-Gn:BSU28970" /db_xref="EnsemblGenomes-Tr:CAB14857" /db_xref="GOA:P06568" /db_xref="InterPro:IPR015414" /db_xref="InterPro:IPR032816" /db_xref="SubtiList:BG10360" /db_xref="UniProtKB/Swiss-Prot:P06568" /translation="MKRKTAVKWLAVLAGAGLLYWGNKTYLNVSPKEIRVWVLSFGVF APLMFIGISIVRPLVLFPVSVISIAGGLAFGPLLGTLYTLFGSMCASAVSFFAAGLFS AKKNGHYERLEAIQKQMEDNGFFYIFLLRILPINFDFVSYAAGLSNVKALPYFAATAV GIIPGTIALNVLGASFLAGNLPAFFMVLALYIVFISLPFIFRKKMQNLFQESN*" /label="ytxB CDS" gene complement(2613625..2614266) /gene="ytxB" /locus_tag="BSU_28970" /old_locus_tag="BSU28970" /label="ytxB gene" CDS complement(2614300..2615235) /gene="dnaI" /locus_tag="BSU_28980" /old_locus_tag="BSU28980" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:12682299, 17003052, 17289076, 19255093, 19968790" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 17003052, 17289076, 19255093, 19968790; Product type f: factor" /codon_start=1 /transl_table=11 /product="helicase loader" /protein_id="NP_390776.1" /db_xref="EnsemblGenomes-Gn:BSU28980" /db_xref="EnsemblGenomes-Tr:CAB14858" /db_xref="GOA:P06567" /db_xref="InterPro:IPR002611" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR009928" /db_xref="InterPro:IPR027417" /db_xref="PDB:2K7R" /db_xref="PDB:4M4W" /db_xref="SubtiList:BG10359" /db_xref="UniProtKB/Swiss-Prot:P06567" /translation="MEPIGRSLQGVTGRPDFQKRLEQMKEKVMKDQDVQAFLKENEEV IDQKMIEKSLNKLYEYIEQSKNCSYCSEDENCNNLLEGYHPKLVVNGRSIDIEYYECP VKRKLDQQKKQQSLMKSMYIQQDLLGATFQQVDISDPSRLAMFQHVTDFLKSYNETGK GKGLYLYGKFGVGKTFMLAAIANELAEKEYSSMIVYVPEFVRELKNSLQDQTLEEKLN MVKTTPVLMLDDIGAESMTSWVRDEVIGTVLQHRMSQQLPTFFSSNFSPDELKHHFTY SQRGEKEEVKAARLMERILYLAAPIRLDGENRRHP*" /label="dnaI CDS" gene complement(2614300..2615235) /gene="dnaI" /locus_tag="BSU_28980" /old_locus_tag="BSU28980" /label="dnaI gene" CDS complement(2615263..2616681) /gene="dnaB" /locus_tag="BSU_28990" /old_locus_tag="BSU28990" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:12682299, 15186423, 16002087, 17289076, 20071750, 21097613, 23525462" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15186423, 16002087, 17289076, 20071750, 21097613, 23525462; Product type f: factor" /codon_start=1 /transl_table=11 /product="helicase loading protein; replication initiationmembrane attachment protein" /protein_id="NP_390777.1" /db_xref="EnsemblGenomes-Gn:BSU28990" /db_xref="EnsemblGenomes-Tr:CAB14859" /db_xref="GOA:P07908" /db_xref="InterPro:IPR006343" /db_xref="InterPro:IPR034829" /db_xref="SubtiList:BG10358" /db_xref="UniProtKB/Swiss-Prot:P07908" /translation="MADYWKDVLPVDPYVVKSRSMLQDIDRQIITQLYQPLIGPVAFS LYMTLWGELEQNRLWGGESTHRQLMGMTQSNLKTIHQEQGKLEGIGLLKVYMKESERQ ERLFIYELLPPLRPNEFFEDGMLNVFLYNRVGKTKYQQLKQFFTHPAISEDAKDITRP FNHAFESLQPSEWKLTSDMEETVRLAEGSEYTSVGQSPSYTITEDVFDFDLFLAGLSE TMIPRKAMTQQVRDTIKKLSYLYGIDPLQMQNVVMSAIDERDVITTEALRKAASDWYQ IERNGQLPDLVEKTQPVHLREGEQPAEEDSLDGKLIALLEAISPKKLLQDIADGTEPS KADLKIIEEIMFEQKLEPGVTNVLIYYVMLKTDMKLSKNYIQKIASHWARKKVKTVRE AMKLAIEENRQYLEWAEGKTKSSKRNQKVIREEKLPDWMTEKETASDSESGQQKLHPQ DLEEQKKKMMEEMQKLKKYSAY*" /label="dnaB CDS" gene complement(2615263..2616681) /gene="dnaB" /locus_tag="BSU_28990" /old_locus_tag="BSU28990" /label="dnaB gene" promotor_-10 complement(2616710..2616729) /Source="Nicolas_upshift_promotors" /id="U2238" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2245 /SigmaFactorBS="ttctagctcttttctcatgtgcaaaattggcATTTgatagat ataagaaACGGTGTAAAATGAAAGGTAgaaacaaattcggaaggtttgagaatgtatg g" /listShort="dnaB, dnaI, ytxB, ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2616718) /Source="Nicolas_upshifts" /id="U2238" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2245 /SigmaFactorBS="ttctagctcttttctcatgtgcaaaattggcATTTgatagat ataagaaACGGTGTAAAATGAAAGGTAgaaacaaattcggaaggtttgagaatgtatg g" /listShort="dnaB, dnaI, ytxB, ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2616744..2616747) /Source="Nicolas_upshift_promotors" /id="U2238" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2245 /SigmaFactorBS="ttctagctcttttctcatgtgcaaaattggcATTTgatagat ataagaaACGGTGTAAAATGAAAGGTAgaaacaaattcggaaggtttgagaatgtatg g" /listShort="dnaB, dnaI, ytxB, ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2616796..2617254) /gene="nrdR" /locus_tag="BSU_29000" /old_locus_tag="BSU29000" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16950922, 27920297, 28624879" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16950922, 27920297, 28624879; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative regulator of transcription of ribonucleotide reductase nrd genes and operons" /protein_id="NP_390778.1" /db_xref="EnsemblGenomes-Gn:BSU29000" /db_xref="EnsemblGenomes-Tr:CAB14860" /db_xref="GOA:Q45549" /db_xref="InterPro:IPR003796" /db_xref="InterPro:IPR005144" /db_xref="SubtiList:BG13833" /db_xref="UniProtKB/Swiss-Prot:Q45549" /translation="MKCPSCQHNGTRVLDSRPVDDGKSIRRRRECESCHYRFTTFEKV EETPLIVVKKEGVREEFSREKMLRGLIKACEKRPVSLKTLEDMCFDIEKELRNQGCSE VKSELVGEMVMDRLAKIDEVAYVRFASVYRQFKDINVFIDELKDLIKKER*" /label="nrdR CDS" gene complement(2616796..2617254) /gene="nrdR" /locus_tag="BSU_29000" /old_locus_tag="BSU29000" /label="nrdR gene" downshifts complement(2616815) /Source="Nicolas_upshifts" /id="D1486" /incds=0 /nref=14 /ntot=175 /MaxReadThrough="4.1553" /MaxDrop="3.90408" /score="12.4797073" /energy="-21.2" /TU="U2239,U2241" /idTUdmin="U2243" /TUdmin="-9" /isTUend="TRUE" /label="downshifts" S_feature complement(2617255..2617402) /Source="Nicolas_S_feature" /locus_tag="new_2966140_2966287_c" /HighExp="dia5, dia15, Lbstat, Diami, Heat, M9-stat, M0t90, M40t90, LBGtran, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigGF, SigA" /TUshortPSig="0.998, 0.996, 0.654, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1091" promotor_-10 complement(2617393..2617412) /Source="Nicolas_upshift_promotors" /id="U2239" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.917082917082917" /psig="0.998001998001998" /xcortree=1862 /SigmaFactorBS="cttttatttttataaagaaacgagagtgtcagCTTTttcttt tttcatttTTTTTGTAAAATAAGAAGGAgattttcacaaaccacctaatgctatagaa a" /listShort="S1091, nrdR, dnaB, dnaI, ytxB, ytxC, S1090" /listLong="NA, thrS" /label="promotor_-10" upshifts complement(2617402) /Source="Nicolas_upshifts" /id="U2239" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.917082917082917" /psig="0.998001998001998" /xcortree=1862 /SigmaFactorBS="cttttatttttataaagaaacgagagtgtcagCTTTttcttt tttcatttTTTTTGTAAAATAAGAAGGAgattttcacaaaccacctaatgctatagaa a" /listShort="S1091, nrdR, dnaB, dnaI, ytxB, ytxC, S1090" /listLong="NA, thrS" /label="upshifts" S_feature complement(2617404..2617482) /Source="Nicolas_S_feature" /locus_tag="new_2966289_2966367_c" /HighExp="Lbstat, M40t90, Heat, M9-stat, M0t90, G180, S8, S5, T1.30H, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF, SigA" /TUshortPSig="0.996, 0.654, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1092" promotor_-35 complement(2617427..2617430) /Source="Nicolas_upshift_promotors" /id="U2239" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.917082917082917" /psig="0.998001998001998" /xcortree=1862 /SigmaFactorBS="cttttatttttataaagaaacgagagtgtcagCTTTttcttt tttcatttTTTTTGTAAAATAAGAAGGAgattttcacaaaccacctaatgctatagaa a" /listShort="S1091, nrdR, dnaB, dnaI, ytxB, ytxC, S1090" /listLong="NA, thrS" /label="promotor_-35" downshifts complement(2617527) /Source="Nicolas_upshifts" /id="D1487" /incds=0 /nref=204 /ntot=262 /MaxReadThrough="5.70146" /MaxDrop="5.85416" /score="12.4797073" /energy="-21.2" /TU="U2241,U2242,U2243" /idTUdmin="U2242" /TUdmin="-237" /isTUend="FALSE" /label="downshifts" CDS complement(2617528..2617908) /gene="speD" /locus_tag="BSU_29010" /old_locus_tag="BSU29010" /EC_number="4.1.1.50" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9723923, 10844697, 28546427" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9723923, 10844697, 28546427; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="S-adenosylmethionine decarboxylase" /protein_id="NP_390779.2" /db_xref="EnsemblGenomes-Gn:BSU29010" /db_xref="EnsemblGenomes-Tr:CAB14861" /db_xref="GOA:O34426" /db_xref="InterPro:IPR003826" /db_xref="InterPro:IPR016067" /db_xref="InterPro:IPR017716" /db_xref="SubtiList:BG13832" /db_xref="UniProtKB/Swiss-Prot:O34426" /translation="METMGRHVISELWGCDFDKLNDMDFIEKTFVNAALKSGAEVREV AFHKFAPQGVSGVVIISESHLTIHSFPEHGYASIDVYTCGDLDPNVAADYIAEALHAD TRENIEIPRGMGPVQIKQAQAKVL*" /label="speD CDS" gene complement(2617528..2617908) /gene="speD" /locus_tag="BSU_29010" /old_locus_tag="BSU29010" /label="speD gene" S_feature complement(2617909..2618063) /Source="Nicolas_S_feature" /locus_tag="new_2966794_2966948_c" /HighExp="Lbstat, M40t90, M9-stat, T2.0H, T3.0H, M0t90, T3.30H, Sw, T1.30H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF, SigA" /TUshortPSig="0.996, 0.654, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1093" promotor_-10 complement(2618043..2618062) /Source="Nicolas_upshift_promotors" /id="U2241" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.613386613386613" /psig="0.996003996003996" /xcortree=337 /SigmaFactorBS="aagaaaaaacccttaacagcatatttctgaaaaaacgcacCT TGCAAattagacttaaacaCAGTATACTATTTTTCGTGAacttcttgcttgagactgt t" /listShort="S1093, speD, S1092, S1091, nrdR, dnaB, dnaI, ytxB, ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2618050 /Source="Nicolas_upshifts" /id="U2240" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.300699300699301" /psig="0.822177822177822" /xcortree=292 /SigmaFactorBS="ccggagaggtcctaaccctttaagtaattccgaaacagtctc aagcaagaagttcacgaaaAATAGTATACTGTGTTTAAGtctaatttgcaaggtgcgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 2618051..2618070 /Source="Nicolas_upshift_promotors" /id="U2240" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.300699300699301" /psig="0.822177822177822" /xcortree=292 /SigmaFactorBS="ccggagaggtcctaaccctttaagtaattccgaaacagtctc aagcaagaagttcacgaaaAATAGTATACTGTGTTTAAGtctaatttgcaaggtgcgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2618063) /Source="Nicolas_upshifts" /id="U2241" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.613386613386613" /psig="0.996003996003996" /xcortree=337 /SigmaFactorBS="aagaaaaaacccttaacagcatatttctgaaaaaacgcacCT TGCAAattagacttaaacaCAGTATACTATTTTTCGTGAacttcttgcttgagactgt t" /listShort="S1093, speD, S1092, S1091, nrdR, dnaB, dnaI, ytxB, ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2618077..2618083) /Source="Nicolas_upshift_promotors" /id="U2241" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.613386613386613" /psig="0.996003996003996" /xcortree=337 /SigmaFactorBS="aagaaaaaacccttaacagcatatttctgaaaaaacgcacCT TGCAAattagacttaaacaCAGTATACTATTTTTCGTGAacttcttgcttgagactgt t" /listShort="S1093, speD, S1092, S1091, nrdR, dnaB, dnaI, ytxB, ytxC, S1090, NA, thrS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2618141..2618152) /Source="Nicolas_upshift_promotors" /id="U2242" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.654345654345654" /psig="0.654345654345654" /xcortree=339 /SigmaFactorBS="gcagagttgttgatctaatccgccatgtagcggcaCGAATGA aacatccgtctgctGTATAAAATAAGgtcatggacacattttaaagaaaaaaccctta a" /listShort="S1093, speD, S1092, S1091" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2618147..2619169) /gene="gapB" /locus_tag="BSU_29020" /old_locus_tag="BSU29020" /EC_number="1.2.1.59" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10799476, 10844697, 15720552, 22720735, 26735940, 27449348, 28760849" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10799476, 10844697, 15720552, 22720735, 26735940, 27449348, 28760849; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glyceraldehyde-3-phosphate dehydrogenase (NADP-dependent, gluconeogenesis)" /protein_id="NP_390780.1" /db_xref="EnsemblGenomes-Gn:BSU29020" /db_xref="EnsemblGenomes-Tr:CAB14862" /db_xref="GOA:O34425" /db_xref="InterPro:IPR006424" /db_xref="InterPro:IPR020828" /db_xref="InterPro:IPR020829" /db_xref="InterPro:IPR020830" /db_xref="InterPro:IPR020831" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12592" /db_xref="UniProtKB/Swiss-Prot:O34425" /translation="MKVKVAINGFGRIGRMVFRKAMLDDQIQVVAINASYSAETLAHL IKYDTIHGRYDKEVVAGEDSLIVNGKKVLLLNSRDPKQLPWREYDIDIVVEATGKFNA KDKAMGHIEAGAKKVILTAPGKNEDVTIVMGVNEDQFDAERHVIISNASCTTNCLAPV VKVLDEEFGIESGLMTTVHAYTNDQKNIDNPHKDLRRARACGESIIPTTTGAAKALSL VLPHLKGKLHGLALRVPVPNVSLVDLVVDLKTDVTAEEVNEAFKRAAKTSMYGVLDYS DEPLVSTDYNTNPHSAVIDGLTTMVMEDRKVKVLAWYDNEWGYSCRVVDLIRHVAARM KHPSAV*" /label="gapB CDS" gene complement(2618147..2619169) /gene="gapB" /locus_tag="BSU_29020" /old_locus_tag="BSU29020" /label="gapB gene" upshifts complement(2618148) /Source="Nicolas_upshifts" /id="U2242" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.654345654345654" /psig="0.654345654345654" /xcortree=339 /SigmaFactorBS="gcagagttgttgatctaatccgccatgtagcggcaCGAATGA aacatccgtctgctGTATAAAATAAGgtcatggacacattttaaagaaaaaaccctta a" /listShort="S1093, speD, S1092, S1091" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2618167..2618173) /Source="Nicolas_upshift_promotors" /id="U2242" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.654345654345654" /psig="0.654345654345654" /xcortree=339 /SigmaFactorBS="gcagagttgttgatctaatccgccatgtagcggcaCGAATGA aacatccgtctgctGTATAAAATAAGgtcatggacacattttaaagaaaaaaccctta a" /listShort="S1093, speD, S1092, S1091" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2619213..2619232) /Source="Nicolas_upshift_promotors" /id="U2243" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=347 /SigmaFactorBS="acataagatgcatcataaattagcgttataatcgttgatttt tatcaatatgTACTGGCGaatttgttttaaTGTGTTATACTAATTTTAGAtagtaaca a" /listShort="gapB, S1093, speD, S1092, S1091, nrdR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2619244) /Source="Nicolas_upshifts" /id="U2243" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=347 /SigmaFactorBS="acataagatgcatcataaattagcgttataatcgttgatttt tatcaatatgTACTGGCGaatttgttttaaTGTGTTATACTAATTTTAGAtagtaaca a" /listShort="gapB, S1093, speD, S1092, S1091, nrdR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2619245..2619252) /Source="Nicolas_upshift_promotors" /id="U2243" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.633366633366633" /psig=1 /xcortree=347 /SigmaFactorBS="acataagatgcatcataaattagcgttataatcgttgatttt tatcaatatgTACTGGCGaatttgttttaaTGTGTTATACTAATTTTAGAtagtaaca a" /listShort="gapB, S1093, speD, S1092, S1091, nrdR" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2619375..2619755) /gene="ytcD" /locus_tag="BSU_29030" /old_locus_tag="BSU29030" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23504016; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (HxlR family)" /protein_id="NP_390781.1" /db_xref="EnsemblGenomes-Gn:BSU29030" /db_xref="EnsemblGenomes-Tr:CAB14863" /db_xref="GOA:O34533" /db_xref="InterPro:IPR002577" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2HZT" /db_xref="SubtiList:BG13831" /db_xref="UniProtKB/Swiss-Prot:O34533" /translation="MEKKKYNISVEATLEVIGGKWKCVILCHLTHGKKRTSELKRLMP NITQKMLTQQLRELEADGVINRIVYNQVPPKVEYELSEYGRSLEGILDMLCAWGANHI NRVYGDTFSVLEESVLNDKLKQES*" /label="ytcD CDS" gene complement(2619375..2619755) /gene="ytcD" /locus_tag="BSU_29030" /old_locus_tag="BSU29030" /label="ytcD gene" downshifts complement(2619399) /Source="Nicolas_upshifts" /id="D1488" /incds=0 /nref=17 /ntot=164 /MaxReadThrough="1.55675" /MaxDrop="3.64816" /score="18.9828659" /energy="-15.3" /TU="NA" /idTUdmin="U2245" /TUdmin=3 /isTUend="TRUE" /label="downshifts" S_feature complement(2619756..2619886) /Source="Nicolas_S_feature" /locus_tag="new_2968641_2968771_c" /HighExp="dia15, Diami, dia5, LBGstat, G180, Etha, S5, LBGtran, H2O2, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.972" /TUlongSig="NA" /TUlongPSig="NA" /label="S1094" promotor_-35 2619811..2619815 /Source="Nicolas_upshift_promotors" /id="U2244" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.87012987012987" /psig="0.972027972027972" /xcortree=2468 /SigmaFactorBS="acaggcaccaaaaagtgactatagcacttcaaagtacgtACT TTtatttcttaacgataTGTTTCATAATCACATTTGCcggctgatttgaatctgctct t" /listShort="S1095, ytbD, ytbE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2619831..2619850 /Source="Nicolas_upshift_promotors" /id="U2244" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.87012987012987" /psig="0.972027972027972" /xcortree=2468 /SigmaFactorBS="acaggcaccaaaaagtgactatagcacttcaaagtacgtACT TTtatttcttaacgataTGTTTCATAATCACATTTGCcggctgatttgaatctgctct t" /listShort="S1095, ytbD, ytbE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2619832..2619938 /Source="Nicolas_S_feature" /locus_tag="new_2968717_2968823" /HighExp="Diami, G180, G135, LBGstat, G150, LBGexp, Paraq, Oxctl, dia5, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.972" /TUlongSig="NA" /TUlongPSig="NA" /label="S1095" upshifts 2619832 /Source="Nicolas_upshifts" /id="U2244" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.87012987012987" /psig="0.972027972027972" /xcortree=2468 /SigmaFactorBS="acaggcaccaaaaagtgactatagcacttcaaagtacgtACT TTtatttcttaacgataTGTTTCATAATCACATTTGCcggctgatttgaatctgctct t" /listShort="S1095, ytbD, ytbE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2619876..2619895) /Source="Nicolas_upshift_promotors" /id="U2245" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.935064935064935" /psig="0.972027972027972" /xcortree=1937 /SigmaFactorBS="gaagtcatgatgttcctcctttgtaagatGTGTTGTAtgatt gaaattctgCCGAGTAAGCTATATAAATAaaaaagagcagattcaaatcagccggcaa a" /listShort="S1094, ytcD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2619886) /Source="Nicolas_upshifts" /id="U2245" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.935064935064935" /psig="0.972027972027972" /xcortree=1937 /SigmaFactorBS="gaagtcatgatgttcctcctttgtaagatGTGTTGTAtgatt gaaattctgCCGAGTAAGCTATATAAATAaaaaagagcagattcaaatcagccggcaa a" /listShort="S1094, ytcD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2619910..2619917) /Source="Nicolas_upshift_promotors" /id="U2245" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.935064935064935" /psig="0.972027972027972" /xcortree=1937 /SigmaFactorBS="gaagtcatgatgttcctcctttgtaagatGTGTTGTAtgatt gaaattctgCCGAGTAAGCTATATAAATAaaaaagagcagattcaaatcagccggcaa a" /listShort="S1094, ytcD" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2619939..2621129 /gene="ytbD" /locus_tag="BSU_29040" /old_locus_tag="BSU29040" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 23504016; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_390782.1" /db_xref="EnsemblGenomes-Gn:BSU29040" /db_xref="EnsemblGenomes-Tr:CAB14864" /db_xref="GOA:O34367" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13825" /db_xref="UniProtKB/Swiss-Prot:O34367" /translation="MTSANKSNIPALLALAVSAFAIGTTEFISVGLLPLIADDLDIPV TTAGLTVSLYALGVTFGAPILTSLTSSMSRKTLLLWIMFIFIAGNTMAATASSIGILL AARVISAFSHGVFMSIGSTIAADIVPEDKRASAISIMFTGLTVATVTGVPFGTFIGQQ FGWRFAFMVIIAVGIIAFITNGILVPSKLRKGTKTTMRDQLKLVTNSRLLLLFVITAL GYGGTFVVFTYLSPLLQEVTGFKAGTVAVILLGYGIAIAIGNMIGGKLSNRNPIAALF YMFIVQAIVLFVLTFTAPYQAAGLITILCMGLLAFMNVPGLQVYVVMLAERFVPSAVD VASAMNIAAFNAGIALGSYLGGVITDSIGLIHTAWIGGLMVVGAVILTGWSRLMEKRD RQEA*" /label="ytbD CDS" gene 2619939..2621129 /gene="ytbD" /locus_tag="BSU_29040" /old_locus_tag="BSU29040" /label="ytbD gene" promotor_-10 complement(2620761..2620779) /Source="Nicolas_upshift_promotors" /id="U2246" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1038 /SigmaFactorBS="agccctgctgcttgatacggggctgtaaatgtcagtaCGAAT AgaacgattgcctgtaCGATAAACATATAGAATAAagcggcaatcggatttcggtttg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2620777) /Source="Nicolas_upshifts" /id="U2246" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1038 /SigmaFactorBS="agccctgctgcttgatacggggctgtaaatgtcagtaCGAAT AgaacgattgcctgtaCGATAAACATATAGAATAAagcggcaatcggatttcggtttg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2620795..2620800) /Source="Nicolas_upshift_promotors" /id="U2246" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1038 /SigmaFactorBS="agccctgctgcttgatacggggctgtaaatgtcagtaCGAAT AgaacgattgcctgtaCGATAAACATATAGAATAAagcggcaatcggatttcggtttg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2621153..2621995 /gene="ytbE" /locus_tag="BSU_29050" /old_locus_tag="BSU29050" /EC_number="1.1.1.-" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:19585557, 20981419, 28032445, 28130301" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19585557, 20981419, 28032445, 28130301; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous aldo/keto reductase" /protein_id="NP_390783.1" /db_xref="EnsemblGenomes-Gn:BSU29050" /db_xref="EnsemblGenomes-Tr:CAB14865" /db_xref="GOA:O34678" /db_xref="InterPro:IPR018170" /db_xref="InterPro:IPR020471" /db_xref="InterPro:IPR023210" /db_xref="InterPro:IPR036812" /db_xref="PDB:3B3D" /db_xref="SubtiList:BG13826" /db_xref="UniProtKB/Swiss-Prot:O34678" /translation="MTTHLQAKATLHNGVEMPWFGLGVFQVEEGSELVNAVKTAIVHG YRSIDTAAIYGNEAGVGEGIREGIEEAGISREDLFITSKVWNADLGYEETLAAFETSL SKLGLDYLDLYLIHWPVEGKYKEAWRALETLYKEGRIKAIGVSNFQIHHLEDLMTAAE IKPMINQVEFHPRLTQKELIRYCQNQGIQMEAWSPLMQGQLLDHPVLADIAQTYNKSV AQIILRWDLQHGIITIPKSTKEHRIKENASVFDFELTQDDMNRIDALNENLRVGPDPD NFDF*" /label="ytbE CDS" gene 2621153..2621995 /gene="ytbE" /locus_tag="BSU_29050" /old_locus_tag="BSU29050" /label="ytbE gene" promotor_-35 2621768..2621773 /Source="Nicolas_upshift_promotors" /id="U2247" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1181 /SigmaFactorBS="ggtcacctttaatgcagggacagctgctggatcaccctGTAT TGgctgacatcgctcaaACATATAATAAATCTGTCGcacaaattattttgcgctggga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2621789..2621807 /Source="Nicolas_upshift_promotors" /id="U2247" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1181 /SigmaFactorBS="ggtcacctttaatgcagggacagctgctggatcaccctGTAT TGgctgacatcgctcaaACATATAATAAATCTGTCGcacaaattattttgcgctggga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2621790 /Source="Nicolas_upshifts" /id="U2247" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1181 /SigmaFactorBS="ggtcacctttaatgcagggacagctgctggatcaccctGTAT TGgctgacatcgctcaaACATATAATAAATCTGTCGcacaaattattttgcgctggga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2621988 /Source="Nicolas_upshifts" /id="D1489" /incds=0 /nref=13 /ntot=124 /MaxReadThrough="1.16017" /MaxDrop="5.72508" /score="24.0721062" /energy="-11.4" /TU="NA" /idTUdmin="U2244" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(2622028) /Source="Nicolas_upshifts" /id="D1490" /incds=0 /nref=168 /ntot=263 /MaxReadThrough="3.38494" /MaxDrop="6.57333" /score="13.4291259" /energy="-11.4" /TU="NA" /idTUdmin="U2248" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" CDS complement(2622037..2622630) /gene="coaE" /locus_tag="BSU_29060" /old_locus_tag="BSU29060" /EC_number="2.7.1.24" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10939241, 11886213, 12538896, 12682299, 15044829, 15526298, 17603993; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dephosphocoenzyme A kinase" /protein_id="NP_390784.1" /db_xref="EnsemblGenomes-Gn:BSU29060" /db_xref="EnsemblGenomes-Tr:CAB14866" /db_xref="GOA:O34932" /db_xref="InterPro:IPR001977" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13824" /db_xref="UniProtKB/Swiss-Prot:O34932" /translation="MTLVIGLTGGIASGKSTVANMLIEKGITVIDADIIAKQAVEKGM PAYRQIIDEFGEDILLSNGDIDRKKLGALVFTNEQKRLALNAIVHPAVRQEMLNRRDE AVANREAFVVLDIPLLFESKLESLVDKIIVVSVTKELQLERLMKRNQLTEEEAVSRIR SQMPLEEKTARADQVIDNSGTLEETKRQLDEIMNSWA*" /label="coaE CDS" gene complement(2622037..2622630) /gene="coaE" /locus_tag="BSU_29060" /old_locus_tag="BSU29060" /label="coaE gene" CDS complement(2622646..2623278) /gene="spcF" /locus_tag="BSU_29070" /old_locus_tag="BSU29070" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 23396918" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 23396918; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="membrane calmodulin-like protein essential for stage III sporulation" /protein_id="NP_390785.2" /db_xref="EnsemblGenomes-Gn:BSU29070" /db_xref="EnsemblGenomes-Tr:CAB14867" /db_xref="GOA:C0SP79" /db_xref="InterPro:IPR003810" /db_xref="InterPro:IPR014205" /db_xref="SubtiList:BG13823" /db_xref="UniProtKB/Swiss-Prot:C0SP79" /translation="MQMVSILLLALAVSLDSFSVGFTYGLRKMKIPFKAILVIACCSG AVMFISMLIGSFLTKFFPVYVTEKLGGLILVGIGAWVLYQFFKPAKDKEYLLHEKTLL NLEVRSLGIVIHILRKPMSADIDKSGVINGIEAVLLGFALSIDAFGAGIGAAILGFSP IVMSIAVAIMSSLFVSIGINAGHFLSKWKWIDKMAFLPGLLLITIGLWKL*" /label="spcF CDS" gene complement(2622646..2623278) /gene="spcF" /locus_tag="BSU_29070" /old_locus_tag="BSU29070" /label="spcF gene" S_feature complement(2623279..2623443) /Source="Nicolas_S_feature" /locus_tag="new_2972164_2972328_c" /HighExp="LPhT, dia15, Sw, LBGtran, LBGstat, H2O2, Diami, G135, Lbstat, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S1096" CDS complement(2623444..2624274) /gene="mutM" /locus_tag="BSU_29080" /old_locus_tag="BSU29080" /EC_number="3.2.2.23" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15109717, 25825434, 28517932; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="formamidopyrimidine-DNA glycosylase; 5-hydroxymethyl-uracil DNA-glycosylase" /protein_id="NP_390786.2" /db_xref="EnsemblGenomes-Gn:BSU29080" /db_xref="EnsemblGenomes-Tr:CAB14868" /db_xref="GOA:O34403" /db_xref="InterPro:IPR000214" /db_xref="InterPro:IPR010663" /db_xref="InterPro:IPR010979" /db_xref="InterPro:IPR012319" /db_xref="InterPro:IPR015886" /db_xref="InterPro:IPR015887" /db_xref="InterPro:IPR020629" /db_xref="InterPro:IPR035937" /db_xref="SubtiList:BG12628" /db_xref="UniProtKB/Swiss-Prot:O34403" /translation="MPELPEVETVRRTLTGLVKGKTIKSVEIRWPNIIKRPAEPEEFA RKLAGETIQSIGRRGKFLLFHLDHYVMVSHLRMEGKYGLHQAEEPDDKHVHVIFTMTD GTQLRYRDVRKFGTMHLFKPGEEAGELPLSQLGPEPDAEEFTSAYLKDRLAKTNRAVK TALLDQKTVVGLGNIYVDEALFRAGVHPETKANQLSDKTIKTLHAEIKNTLQEAIDAG GSTVRSYINSQGEIGMFQLQHFVYGKKDEPCKNCGTMISKIVVGGRGTHFCAKCQTKK *" /label="mutM CDS" gene complement(2623444..2624274) /gene="mutM" /locus_tag="BSU_29080" /old_locus_tag="BSU29080" /label="mutM gene" CDS complement(2624297..2626939) /gene="polA" /locus_tag="BSU_29090" /old_locus_tag="BSU29090" /EC_number="2.7.7.7" /function="16.9: Replicate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:3125407, 6777244, 9231429, 12081953, 17905985, 27399782" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3125407, 6777244, 9231429, 12081953, 17905985, 27399782; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="DNA polymerase I" /protein_id="NP_390787.1" /db_xref="EnsemblGenomes-Gn:BSU29090" /db_xref="EnsemblGenomes-Tr:CAB14869" /db_xref="GOA:O34996" /db_xref="InterPro:IPR001098" /db_xref="InterPro:IPR002298" /db_xref="InterPro:IPR002421" /db_xref="InterPro:IPR002562" /db_xref="InterPro:IPR008918" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR018320" /db_xref="InterPro:IPR019760" /db_xref="InterPro:IPR020045" /db_xref="InterPro:IPR020046" /db_xref="InterPro:IPR029060" /db_xref="InterPro:IPR036279" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG12656" /db_xref="UniProtKB/Swiss-Prot:O34996" /translation="MTERKKLVLVDGNSLAYRAFFALPLLSNDKGVHTNAVYGFAMIL MKMLEDEKPTHMLVAFDAGKTTFRHGTFKEYKGGRQKTPPELSEQMPFIRELLDAYQI SRYELEQYEADDIIGTLAKSAEKDGFEVKVFSGDKDLTQLATDKTTVAITRKGITDVE FYTPEHVKEKYGLTPEQIIDMKGLMGDSSDNIPGVPGVGEKTAIKLLKQFDSVEKLLE SIDEVSGKKLKEKLEEFKDQALMSKELATIMTDAPIEVSVSGLEYQGFNREQVIAIFK DLGFNTLLERLGEDSAEAEQDQSLEDINVKTVTDVTSDILVSPSAFVVEQIGDNYHEE PILGFSIVNETGAYFIPKDIAVESEVFKEWVENDEQKKWVFDSKRAVVALRWQGIELK GAEFDTLLAAYIINPGNSYDDVASVAKDYGLHIVSSDESVYGKGAKRAVPSEDVLSEH LGRKALAIQSLREKLVQELENNDQLELFEELEMPLALILGEMESTGVKVDVDRLKRMG EELGAKLKEYEEKIHEIAGEPFNINSPKQLGVILFEKIGLPVVKKTKTGYSTSADVLE KLADKHDIVDYILQYRQIGKLQSTYIEGLLKVTRPDSHKVHTRFNQALTQTGRLSSTD PNLQNIPIRLEEGRKIRQAFVPSEKDWLIFAADYSQIELRVLAHISKDENLIEAFTND MDIHTKTAMDVFHVAKDEVTSAMRRQAKAVNFGIVYGISDYGLSQNLGITRKEAGAFI DRYLESFQGVKAYMEDSVQEAKQKGYVTTLMHRRRYIPELTSRNFNIRSFAERTAMNT PIQGSAADIIKKAMIDMAAKLKEKQLKARLLLQVHDELIFEAPKEEIEILEKLVPEVM EHALALDVPLKVDFASGPSWYDAK*" /label="polA CDS" gene complement(2624297..2626939) /gene="polA" /locus_tag="BSU_29090" /old_locus_tag="BSU29090" /label="polA gene" promotor_-10 complement(2626994..2627013) /Source="Nicolas_upshift_promotors" /id="U2248" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=1979 /SigmaFactorBS="cttttttgtgtcttctcttatagttcacgTATTTTCCtttca aattgaacTTTGTTAAAATAAGAGGAGCtaatgactatgtaagagatgaatggaagcc t" /listShort="polA, mutM, S1096, ytaF, coaE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2627003) /Source="Nicolas_upshifts" /id="U2248" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=1979 /SigmaFactorBS="cttttttgtgtcttctcttatagttcacgTATTTTCCtttca aattgaacTTTGTTAAAATAAGAGGAGCtaatgactatgtaagagatgaatggaagcc t" /listShort="polA, mutM, S1096, ytaF, coaE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2627027..2627034) /Source="Nicolas_upshift_promotors" /id="U2248" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.778221778221778" /psig=1 /xcortree=1979 /SigmaFactorBS="cttttttgtgtcttctcttatagttcacgTATTTTCCtttca aattgaacTTTGTTAAAATAAGAGGAGCtaatgactatgtaagagatgaatggaagcc t" /listShort="polA, mutM, S1096, ytaF, coaE" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2627063..2627182) /Source="Nicolas_S_feature" /locus_tag="new_2975948_2976067_c" /HighExp="M0t90, M40t90, M9-stat, Lbstat, Sw, T1.30H, T1.0H, S4, S3, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.995, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1097" downshifts complement(2627106) /Source="Nicolas_upshifts" /id="D1491" /incds=0 /nref=48 /ntot=175 /MaxReadThrough="5.58383" /MaxDrop="3.85702" /score="15.0073484" /energy="-12.2" /TU="U2249" /idTUdmin="U2254" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" CDS complement(2627183..2628922) /gene="phoR" /locus_tag="BSU_29100" /old_locus_tag="BSU29100" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:10433720, 12486063, 14762014, 15205429, 16430694, 16452408, 17085571, 20487291, 23145827, 25315493, 25355628" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10433720, 12486063, 14762014, 15205429, 16430694, 16452408, 17085571, 20487291, 23145827, 25315493, 25355628; Product type rc : receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase" /protein_id="NP_390788.1" /db_xref="EnsemblGenomes-Gn:BSU29100" /db_xref="EnsemblGenomes-Tr:CAB14870" /db_xref="GOA:P23545" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR013767" /db_xref="InterPro:IPR031967" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="PDB:3CWF" /db_xref="SubtiList:BG10364" /db_xref="UniProtKB/Swiss-Prot:P23545" /translation="MNKYRVRLFSVFVVCMILVFCVLGLFLQQLFETSDQRKAEEHIE KEAKYLASLLDAGNLNNQANEKIIKDAGGALDVSASVIDTDGKVLYGSNGRSADSQKV QALVSGHEGILSTTDNKLYYGLSLRSEGEKTGYVLLSASEKSDGLKGELWGMLTASLC TAFIVIVYFYSSMTSRYKRSIESATNVATELSKGNYDARTYGGYIRRSDKLGHAMNSL AIDLMEMTRTQEMQRDRLLTVIENIGSGLIMIDGRGFINLVNRSYAKQFHINPNHMLR RLYHDAFEHEEVIQLVEDIFMTETKKCKLLRLPIKIERRYFEVDGVPIMGPDDEWKGI VLVFHDMTETKKLEQMRKDFVANVSHELKTPITSIKGFTETLLDGAMEDKEALSEFLS IILKESERLQSLVQDLLDLSKIEQQNFTLSIETFEPAKMLGEIETLLKHKADEKGISL HLNVPKDPQYVSGDPYRLKQVFLNLVNNALTYTPEGGSVAINVKPREKDIQIEVADSG IGIQKEEIPRIFERFYRVDKDRSRNSGGTGLGLAIVKHLIEAHEGKIDVTSELGRGTV FTVTLKRAAEKSA*" /label="phoR CDS" gene complement(2627183..2628922) /gene="phoR" /locus_tag="BSU_29100" /old_locus_tag="BSU29100" /label="phoR gene" CDS complement(2628915..2629637) /gene="phoP" /locus_tag="BSU_29110" /old_locus_tag="BSU29110" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14762014, 14973033, 15205429, 16030210, 16452408, 16816204, 16980498, 17085571, 20487291, 22720735, 23145827, 25315493, 25355628" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14762014, 14973033, 15205429, 16030210, 16452408, 16816204, 16980498, 17085571, 20487291, 22720735, 23145827, 25315493, 25355628; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator" /protein_id="NP_390789.2" /db_xref="EnsemblGenomes-Gn:BSU29110" /db_xref="EnsemblGenomes-Tr:CAB14871" /db_xref="GOA:P13792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="PDB:1MVO" /db_xref="SubtiList:BG10363" /db_xref="UniProtKB/Swiss-Prot:P13792" /translation="MNKKILVVDDEESIVTLLQYNLERSGYDVITASDGEEALKKAET EKPDLIVLDVMLPKLDGIEVCKQLRQQKLMFPILMLTAKDEEFDKVLGLELGADDYMT KPFSPREVNARVKAILRRSEIAAPSSEMKNDEMEGQIVIGDLKILPDHYEAYFKESQL ELTPKEFELLLYLGRHKGRVLTRDLLLSAVWNYDFAGDTRIVDVHISHLRDKIENNTK KPIYIKTIRGLGYKLEEPKMNE*" /label="phoP CDS" gene complement(2628915..2629637) /gene="phoP" /locus_tag="BSU_29110" /old_locus_tag="BSU29110" /label="phoP gene" promotor_-10 complement(2629705..2629724) /Source="Nicolas_upshift_promotors" /id="U2249" /multdbtbs="SigA,SigA,SigE" /comp="M19" /sig="SigA" /pcomp="0.427572427572428" /psig="0.995004995004995" /xcortree=1405 /SigmaFactorBS="tttatttcttttaaaaatgatgtaaaaggcgAATTGTCggaa tgtcctgctTTCGCTAAAATAAAATCATGaaacatgttaagatgacataaaatagaga a" /listShort="phoP, phoR, S1097, polA, mutM, S1096, ytaF, coaE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2629715) /Source="Nicolas_upshifts" /id="U2249" /multdbtbs="SigA,SigA,SigE" /comp="M19" /sig="SigA" /pcomp="0.427572427572428" /psig="0.995004995004995" /xcortree=1405 /SigmaFactorBS="tttatttcttttaaaaatgatgtaaaaggcgAATTGTCggaa tgtcctgctTTCGCTAAAATAAAATCATGaaacatgttaagatgacataaaatagaga a" /listShort="phoP, phoR, S1097, polA, mutM, S1096, ytaF, coaE" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2629717..2629817) /Source="Nicolas_S_feature" /locus_tag="new_2978602_2978702_c" /HighExp="M40t90, T1.30H, T1.0H, M0t90, M9-stat, T2.0H, T2.30H, T3.0H, T0.30H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1098" promotor_-35 complement(2629738..2629744) /Source="Nicolas_upshift_promotors" /id="U2249" /multdbtbs="SigA,SigA,SigE" /comp="M19" /sig="SigA" /pcomp="0.427572427572428" /psig="0.995004995004995" /xcortree=1405 /SigmaFactorBS="tttatttcttttaaaaatgatgtaaaaggcgAATTGTCggaa tgtcctgctTTCGCTAAAATAAAATCATGaaacatgttaagatgacataaaatagaga a" /listShort="phoP, phoR, S1097, polA, mutM, S1096, ytaF, coaE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2629849..2630787) /gene="mdh" /locus_tag="BSU_29120" /old_locus_tag="BSU29120" /EC_number="1.1.1.37" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6319195, 8550482, 12034826, 16788182, 22720735, 23136871, 24325460, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6319195, 8550482, 12034826, 16788182, 22720735, 23136871, 24325460, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="malate dehydrogenase (NAD-dependent)" /protein_id="NP_390790.1" /db_xref="EnsemblGenomes-Gn:BSU29120" /db_xref="EnsemblGenomes-Tr:CAB14872" /db_xref="GOA:P49814" /db_xref="InterPro:IPR001236" /db_xref="InterPro:IPR001557" /db_xref="InterPro:IPR011275" /db_xref="InterPro:IPR015955" /db_xref="InterPro:IPR022383" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11386" /db_xref="UniProtKB/Swiss-Prot:P49814" /translation="MGNTRKKVSVIGAGFTGATTAFLIAQKELADVVLVDIPQLENPT KGKALDMLEASPVQGFDAKITGTSNYEDTAGSDIVVITAGIARKPGMSRDDLVSTNEK IMRSVTQEIVKYSPDSIIVVLTNPVDAMTYAVYKESGFPKERVIGQSGVLDTARFRTF VAEELNLSVKDVTGFVLGGHGDDMVPLVRYSYAGGIPLETLIPKERIDAIVERTRKGG GEIVNLLGNGSAYYAPAASLTEMVEAILKDQRRVLPTIAYLEGEYGYEGIYLGVPTIV GGNGLEQIIELELTDYERAQLNKSVESVKNVMKVLS*" /label="mdh CDS" gene complement(2629849..2630787) /gene="mdh" /locus_tag="BSU_29120" /old_locus_tag="BSU29120" /label="mdh gene" downshifts complement(2629862) /Source="Nicolas_upshifts" /id="D1492" /incds=0 /nref=200 /ntot=242 /MaxReadThrough="8.27126" /MaxDrop="7.40884" /score="-0.758981483" /energy="-13.5" /TU="U2251,U2254" /idTUdmin="U2250" /TUdmin="-9" /isTUend="TRUE" /label="downshifts" CDS complement(2630831..2632102) /gene="icd" /locus_tag="BSU_29130" /old_locus_tag="BSU29130" /EC_number="1.1.1.42" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8045898, 9244258, 11290745, 24325460" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045898, 9244258, 11290745, 24325460; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isocitrate dehydrogenase" /protein_id="NP_390791.1" /db_xref="EnsemblGenomes-Gn:BSU29130" /db_xref="EnsemblGenomes-Tr:CAB14873" /db_xref="GOA:P39126" /db_xref="InterPro:IPR004439" /db_xref="InterPro:IPR019818" /db_xref="InterPro:IPR024084" /db_xref="PDB:1HQS" /db_xref="SubtiList:BG10856" /db_xref="UniProtKB/Swiss-Prot:P39126" /translation="MAQGEKITVSNGVLNVPNNPIIPFIEGDGTGPDIWNAASKVLEA AVEKAYKGEKKITWKEVYAGEKAYNKTGEWLPAETLDVIREYFIAIKGPLTTPVGGGI RSLNVALRQELDLFVCLRPVRYFTGVPSPVKRPEDTDMVIFRENTEDIYAGIEYAKGS EEVQKLISFLQNELNVNKIRFPETSGIGIKPVSEEGTSRLVRAAIDYAIEHGRKSVTL VHKGNIMKFTEGAFKNWGYELAEKEYGDKVFTWAQYDRIAEEQGKDAANKAQSEAEAA GKIIIKDSIADIFLQQILTRPNEFDVVATMNLNGDYISDALAAQVGGIGIAPGANINY ETGHAIFEATHGTAPKYAGLDKVNPSSVILSGVLLLEHLGWNEAADLVIKSMEKTIAS KVVTYDFARLMDGATEVKCSEFGEELIKNMD*" /label="icd CDS" gene complement(2630831..2632102) /gene="icd" /locus_tag="BSU_29130" /old_locus_tag="BSU29130" /label="icd gene" misc_feature complement(2631887..2631906) /Source="Nicolas_upshift_promotors" /id="U2250" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.46953046953047" /psig="0.95004995004995" /xcortree=3208 /SigmaFactorBS="agcatacaaaggcgaaaagaaaattacatggaaagaagttta cgccggagaaaAGGCTTATAATAAAACAGGTgagtggctccctgctgaaacattagat g" /listShort="mdh" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2631899) /Source="Nicolas_upshifts" /id="U2250" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.46953046953047" /psig="0.95004995004995" /xcortree=3208 /SigmaFactorBS="agcatacaaaggcgaaaagaaaattacatggaaagaagttta cgccggagaaaAGGCTTATAATAAAACAGGTgagtggctccctgctgaaacattagat g" /listShort="mdh" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2632103..2632185) /Source="Nicolas_S_feature" /locus_tag="new_2980988_2981070_c" /HighExp="T2.30H, M40t90, T1.0H, T-3.40H, HiOs, T3.30H, T3.0H, T0.0H, Lbstat, T-5.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1099" upshifts complement(2632185) /Source="Nicolas_upshifts" /id="U2251" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.568431568431568" /psig=1 /xcortree=3209 /SigmaFactorBS="tgcgtcaatgaggttagccTCTTGttcagacatcaaaatTGG GTTACACTTTAAATTGAatgttaggaaaaatcattttattttctatataagaaaaata a" /listShort="S1099, icd, mdh, S1098" /listLong="phoP, phoR" /label="upshifts" S_feature complement(2632187..2632265) /Source="Nicolas_S_feature" /locus_tag="new_2981072_2981150_c" /HighExp="T2.30H, T3.30H, T1.0H, M40t90, T3.0H, Lbstat, M0t90, T0.0H, HiOs, T-0.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1100" promotor_-10 complement(2632187..2632206) /Source="Nicolas_upshift_promotors" /id="U2251" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.568431568431568" /psig=1 /xcortree=3209 /SigmaFactorBS="tgcgtcaatgaggttagccTCTTGttcagacatcaaaatTGG GTTACACTTTAAATTGAatgttaggaaaaatcattttattttctatataagaaaaata a" /listShort="S1099, icd, mdh, S1098" /listLong="phoP, phoR" /label="promotor_-10" promotor_-35 complement(2632222..2632226) /Source="Nicolas_upshift_promotors" /id="U2251" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.568431568431568" /psig=1 /xcortree=3209 /SigmaFactorBS="tgcgtcaatgaggttagccTCTTGttcagacatcaaaatTGG GTTACACTTTAAATTGAatgttaggaaaaatcattttattttctatataagaaaaata a" /listShort="S1099, icd, mdh, S1098" /listLong="phoP, phoR" /label="promotor_-35" CDS complement(2632266..2633384) /gene="citZ" /locus_tag="BSU_29140" /old_locus_tag="BSU29140" /EC_number="2.3.3.16" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8655569, 10656796, 11985717, 12100558, 19202299, 22720735, 23139400, 23354745" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8655569, 10656796, 11985717, 12100558, 19202299, 22720735, 23139400, 23354745; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="citrate synthase II" /protein_id="NP_390792.1" /db_xref="EnsemblGenomes-Gn:BSU29140" /db_xref="EnsemblGenomes-Tr:CAB14874" /db_xref="GOA:P39120" /db_xref="InterPro:IPR002020" /db_xref="InterPro:IPR011278" /db_xref="InterPro:IPR016142" /db_xref="InterPro:IPR019810" /db_xref="InterPro:IPR024176" /db_xref="InterPro:IPR036969" /db_xref="SubtiList:BG10855" /db_xref="UniProtKB/Swiss-Prot:P39120" /translation="MTATRGLEGVVATTSSVSSIIDDTLTYVGYDIDDLTENASFEEI IYLLWHLRLPNKKELEELKQQLAKEAAVPQEIIEHFKSYSLENVHPMAALRTAISLLG LLDSEADTMNPEANYRKAIRLQAKVPGLVAAFSRIRKGLEPVEPREDYGIAENFLYTL NGEEPSPIEVEAFNKALILHADHELNASTFTARVCVATLSDIYSGITAAIGALKGPLH GGANEGVMKMLTEIGEVENAEPYIRAKLEKKEKIMGFGHRVYKHGDPRAKHLKEMSKR LTNLTGESKWYEMSIRIEDIVTSEKKLPPNVDFYSASVYHSLGIDHDLFTPIFAVSRM SGWLAHILEQYDNNRLIRPRADYTGPDKQKFVPIEERA*" /label="citZ CDS" gene complement(2632266..2633384) /gene="citZ" /locus_tag="BSU_29140" /old_locus_tag="BSU29140" /label="citZ gene" downshifts 2632879 /Source="Nicolas_upshifts" /id="D1493" /incds=1 /nref=2 /ntot=63 /MaxReadThrough="1.41638" /MaxDrop="3.70762" /score="40.6931963" /energy="-9.9" /TU="NA" /idTUdmin="U2252" /TUdmin="-506" /isTUend="FALSE" /label="downshifts" misc_feature 2633226..2633229 /Source="Nicolas_upshift_promotors" /id="U2252" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.985014985014985" /psig="0.002997002997003" /xcortree=74 /SigmaFactorBS="cagcttcctttgcaagctgctgctttaactcttcaagctctt ttttgtttggCAGCcttagatgccaaagcaagtagatgatttcttcaaaacttgcatt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2633234 /Source="Nicolas_upshifts" /id="U2252" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.985014985014985" /psig="0.002997002997003" /xcortree=74 /SigmaFactorBS="cagcttcctttgcaagctgctgctttaactcttcaagctctt ttttgtttggCAGCcttagatgccaaagcaagtagatgatttcttcaaaacttgcatt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2633363 /Source="Nicolas_upshifts" /id="D1494" /incds=0 /nref=1 /ntot=126 /MaxReadThrough="2.98678" /MaxDrop="3.07929" /score="40.6931963" /energy="-9.9" /TU="U2252" /idTUdmin="U2252" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" S_feature complement(2633385..2633591) /Source="Nicolas_S_feature" /locus_tag="new_2982270_2982476_c" /HighExp="T3.0H, T3.30H, T2.30H, T4.0H, M0t90, T2.0H, T1.30H, T5.0H, BC, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1101" misc_feature 2633559..2633571 /Source="Nicolas_upshift_promotors" /id="U2253" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.467532467532468" /psig="0.464535464535465" /xcortree=721 /SigmaFactorBS="ctggaactaaaaccctttgcttttgaaagaacataacaaatt tttataaGCTTATTTAAGTTtaagcctattctcattataaacaataatcagacatttg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2633570 /Source="Nicolas_upshifts" /id="U2253" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.467532467532468" /psig="0.464535464535465" /xcortree=721 /SigmaFactorBS="ctggaactaaaaccctttgcttttgaaagaacataacaaatt tttataaGCTTATTTAAGTTtaagcctattctcattataaacaataatcagacatttg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2633577..2633596) /Source="Nicolas_upshift_promotors" /id="U2254" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.573426573426573" /psig=1 /xcortree=493 /SigmaFactorBS="aaatcacagaatggaaaaaaaaaattataggtaaacATTTAa caaatgtctgattATTGTTTATAATGAGAATAGgcttaaacttaaataagcttataaa a" /listShort="S1101, citZ, S1100, S1099, icd, mdh, S1098, phoP, phoR, S1097" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2633591) /Source="Nicolas_upshifts" /id="U2254" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.573426573426573" /psig=1 /xcortree=493 /SigmaFactorBS="aaatcacagaatggaaaaaaaaaattataggtaaacATTTAa caaatgtctgattATTGTTTATAATGAGAATAGgcttaaacttaaataagcttataaa a" /listShort="S1101, citZ, S1100, S1099, icd, mdh, S1098, phoP, phoR, S1097" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2633611..2633615) /Source="Nicolas_upshift_promotors" /id="U2254" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.573426573426573" /psig=1 /xcortree=493 /SigmaFactorBS="aaatcacagaatggaaaaaaaaaattataggtaaacATTTAa caaatgtctgattATTGTTTATAATGAGAATAGgcttaaacttaaataagcttataaa a" /listShort="S1101, citZ, S1100, S1099, icd, mdh, S1098, phoP, phoR, S1097" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2633711) /Source="Nicolas_upshifts" /id="D1495" /incds=0 /nref=116 /ntot=204 /MaxReadThrough="6.4946" /MaxDrop="5.00031" /score="29.3344463" /energy="-8.1" /TU="NA" /idTUdmin="U2255" /TUdmin=14 /isTUend="TRUE" /label="downshifts" CDS complement(2633718..2634182) /gene="ytwI" /locus_tag="BSU_29150" /old_locus_tag="BSU29150" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_390793.1" /db_xref="EnsemblGenomes-Gn:BSU29150" /db_xref="EnsemblGenomes-Tr:CAB14875" /db_xref="GOA:O34811" /db_xref="InterPro:IPR007382" /db_xref="SubtiList:BG13933" /db_xref="UniProtKB/Swiss-Prot:O34811" /translation="MFTQANLFLILLLAIALIAKNQSLLFAVSVLLIIKIVGLDQKLF PTIQSKGINWGVTIITIAVLVPIATGEIGFKQLGEAMRSSYAWIALGAGIAVALIAKN GLTLLENDPHITTALVIGTILAVALFGGVAVGPLIGAGIAYLAMQIVKLFTS*" /label="ytwI CDS" gene complement(2633718..2634182) /gene="ytwI" /locus_tag="BSU_29150" /old_locus_tag="BSU29150" /label="ytwI gene" promotor_-10 complement(2634195..2634214) /Source="Nicolas_upshift_promotors" /id="U2255" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.774225774225774" /psig="0.774225774225774" /xcortree=1276 /SigmaFactorBS="cctcctctcgtcagcatgtcctattttttatatgTATTCACG CtgcggctgaataTGAATACATTCATCTTAAAGgagggatggcatgtgtttacacaag c" /listShort="ytwI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2634209) /Source="Nicolas_upshifts" /id="U2255" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.774225774225774" /psig="0.774225774225774" /xcortree=1276 /SigmaFactorBS="cctcctctcgtcagcatgtcctattttttatatgTATTCACG CtgcggctgaataTGAATACATTCATCTTAAAGgagggatggcatgtgtttacacaag c" /listShort="ytwI" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2634211..2635396) /Source="Nicolas_S_feature" /locus_tag="new_2983096_2984281_c" /HighExp="G135, G180, LBGstat, G150, LBGtran, S0, Paraq, Oxctl, H2O2, LBGexp" /AntisenseName="ytvI" /AntisenseCor="-0.73323145377324295" /AntisenseRegPval="-45.9" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1102" promotor_-35 2634211..2634216 /Source="Nicolas_upshift_promotors" /id="U2256" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=994 /SigmaFactorBS="aaacacatgccatccctcctttaagatgaatgtaTTCATAtt cagccgcagcgtGAATACATATAAAAAATAGgacatgctgacgagaggaggaccgttt t" /listShort="ytvI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(2634227..2634235) /Source="Nicolas_upshift_promotors" /id="U2255" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.774225774225774" /psig="0.774225774225774" /xcortree=1276 /SigmaFactorBS="cctcctctcgtcagcatgtcctattttttatatgTATTCACG CtgcggctgaataTGAATACATTCATCTTAAAGgagggatggcatgtgtttacacaag c" /listShort="ytwI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2634231..2634249 /Source="Nicolas_upshift_promotors" /id="U2256" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=994 /SigmaFactorBS="aaacacatgccatccctcctttaagatgaatgtaTTCATAtt cagccgcagcgtGAATACATATAAAAAATAGgacatgctgacgagaggaggaccgttt t" /listShort="ytvI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2634237 /Source="Nicolas_upshifts" /id="U2256" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=994 /SigmaFactorBS="aaacacatgccatccctcctttaagatgaatgtaTTCATAtt cagccgcagcgtGAATACATATAAAAAATAGgacatgctgacgagaggaggaccgttt t" /listShort="ytvI" /GFF_Attribute="listLong" /label="upshifts" CDS 2634279..2635394 /gene="ytvI" /locus_tag="BSU_29160" /old_locus_tag="BSU29160" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12662922, 15849754, 16850406, 26735940; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative sporulation-related permease" /protein_id="NP_390794.1" /db_xref="EnsemblGenomes-Gn:BSU29160" /db_xref="EnsemblGenomes-Tr:CAB14876" /db_xref="GOA:O34991" /db_xref="InterPro:IPR002549" /db_xref="InterPro:IPR014227" /db_xref="SubtiList:BG13930" /db_xref="UniProtKB/Swiss-Prot:O34991" /translation="MNQSYITIFFRTLFVISMTAGSIAAAYYSFPLTYPFLIALILSS VIHPVVDYLDKVTGFPRTINVLGVLAFFLLAAFGVLTILVAEIVTGTAYLAKTLPPHI STFISYCEKLFTTHIQPLYNELTLLFQELETNQQASIVTHIQTLGDSAAKNAGLLLSH ILEMIPRFFALLPNTAAVLIFSLLATFFMTKDWHKLKAMLVLILPDRVTANSKAISSE LKKAMTGFIKAQAVLVFITMVIVFIGLSLLKVEHAATIAFLIGLVDLLPYLGAGSVFV PWILYLSITGQLPQAIGIGILYLVVLIQRQLTEPKILSKSIGIDPLATLIALFAGFKL FGFLGLIAGPAVLVIIQAFITTGALKEIWSYITVQQK*" /label="ytvI CDS" gene 2634279..2635394 /gene="ytvI" /locus_tag="BSU_29160" /old_locus_tag="BSU29160" /label="ytvI gene" downshifts 2635365 /Source="Nicolas_upshifts" /id="D1496" /incds=0 /nref=2 /ntot=24 /MaxReadThrough="1.639" /MaxDrop="3.31897" /score="37.6858539" /energy="-16.7" /TU="NA" /idTUdmin="U2256" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2635427..2635810) /gene="ytzA" /locus_tag="BSU_29170" /old_locus_tag="BSU29170" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15302217, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390795.1" /db_xref="EnsemblGenomes-Gn:BSU29170" /db_xref="EnsemblGenomes-Tr:CAB14877" /db_xref="GOA:O32064" /db_xref="InterPro:IPR007313" /db_xref="SubtiList:BG13935" /db_xref="UniProtKB/Swiss-Prot:O32064" /translation="MRFLFLLFIVFPAIEIGIFLFLGNLIGILPTVLFMILTGIIGAA AAKKQGTEVYYKVQRDLQYGKMPGEAIADGLCIFIGGLLLMLPGFLSDLAGACLLIPF TRGWCKPILFKWLRGMSKNKRIIIK*" /label="ytzA CDS" gene complement(2635427..2635810) /gene="ytzA" /locus_tag="BSU_29170" /old_locus_tag="BSU29170" /label="ytzA gene" downshifts complement(2635441) /Source="Nicolas_upshifts" /id="D1497" /incds=0 /nref=181 /ntot=256 /MaxReadThrough="4.28884" /MaxDrop="5.74703" /score="18.319512" /energy="-13.8" /TU="NA" /idTUdmin="U2257" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2635811..2635902) /Source="Nicolas_S_feature" /locus_tag="new_2984696_2984787_c" /HighExp="G135, LBGtran, G150, LBGexp, M0t45, Lbexp, S0, G180, Oxctl, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 1" /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S1103" CDS complement(2635903..2637660) /gene="pyk" /locus_tag="BSU_29180" /old_locus_tag="BSU29180" /EC_number="2.7.1.40" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10559165, 10932722, 10966427, 11489127, 17022686, 18586936, 22846916, 24825009" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10559165, 10932722, 10966427, 11489127, 17022686, 18586936, 22846916, 24825009; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyruvate kinase" /protein_id="NP_390796.1" /db_xref="EnsemblGenomes-Gn:BSU29180" /db_xref="EnsemblGenomes-Tr:CAB14878" /db_xref="GOA:P80885" /db_xref="InterPro:IPR001697" /db_xref="InterPro:IPR008279" /db_xref="InterPro:IPR011037" /db_xref="InterPro:IPR015793" /db_xref="InterPro:IPR015795" /db_xref="InterPro:IPR015813" /db_xref="InterPro:IPR018209" /db_xref="InterPro:IPR036918" /db_xref="SubtiList:BG12661" /db_xref="UniProtKB/Swiss-Prot:P80885" /translation="MRKTKIVCTIGPASESIEMLTKLMESGMNVARLNFSHGDFEEHG ARIKNIREASKKLGKNVGILLDTKGPEIRTHTMENGGIELETGKELIISMDEVVGTTD KISVTYEGLVHDVEQGSTILLDDGLIGLEVLDVDAAKREIKTKVLNNGTLKNKKGVNV PGVSVNLPGITEKDARDIVFGIEQGVDFIAPSFIRRSTDVLEIRELLEEHNAQDIQII PKIENQEGVDNIDAILEVSDGLMVARGDLGVEIPAEEVPLVQKELIKKCNALGKPVIT ATQMLDSMQRNPRPTRAEASDVANAIFDGTDAIMLSGETAAGSYPVEAVQTMHNIASR SEEALNYKEILSKRRDQVGMTITDAIGQSVAHTAINLNAAAIVTPTESGHTARMIAKY RPQAPIVAVTVNDSISRKLALVSGVFAESGQNASSTDEMLEDAVQKSLNSGIVKHGDL IVITAGTVGESGTTNLMKVHTVGDIIAKGQGIGRKSAYGPVVVAQNAKEAEQKMTDGA VLVTKSTDRDMIASLEKASALITEEGGLTSHAAVVGLSLGIPVIVGLENATSILTDGQ DITVDASRGAVYQGRASVL*" /label="pyk CDS" gene complement(2635903..2637660) /gene="pyk" /locus_tag="BSU_29180" /old_locus_tag="BSU29180" /label="pyk gene" CDS complement(2637703..2638662) /gene="pfkA" /locus_tag="BSU_29190" /old_locus_tag="BSU29190" /EC_number="2.7.1.11" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12450869, 12622823, 12682299, 19193632, 20473954, 22198292" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12450869, 12622823, 12682299, 19193632, 20473954, 22198292; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="6-phosphofructokinase" /protein_id="NP_390797.1" /db_xref="EnsemblGenomes-Gn:BSU29190" /db_xref="EnsemblGenomes-Tr:CAB14879" /db_xref="GOA:O34529" /db_xref="InterPro:IPR000023" /db_xref="InterPro:IPR012003" /db_xref="InterPro:IPR012828" /db_xref="InterPro:IPR015912" /db_xref="InterPro:IPR022953" /db_xref="InterPro:IPR035966" /db_xref="PDB:4A3S" /db_xref="SubtiList:BG12644" /db_xref="UniProtKB/Swiss-Prot:O34529" /translation="MKRIGVLTSGGDSPGMNAAVRAVVRKAIYHDVEVYGIYNGYAGL ISGKIEKLELGSVGDIIHRGGTKLYTARCPEFKTVEGREKGIANLKKLGIEGLVVIGG DGSYMGAKKLTEHGFPCVGVPGTIDNDIPGTDFTIGFDTALNTVIDAIDKIRDTATSH ERTYVIEVMGRHAGDIALWAGLAGGAESILIPEADYDMHEIIARLKRGHERGKKHSII IVAEGVGSGVEFGKRIEEETNLETRVSVLGHIQRGGSPSAADRVLASRLGAYAVELLL EGKGGRCVGIQNNKLVDHDIIEILETKHTVEQNMYQLSKELSI*" /label="pfkA CDS" gene complement(2637703..2638662) /gene="pfkA" /locus_tag="BSU_29190" /old_locus_tag="BSU29190" /label="pfkA gene" S_feature complement(2638663..2638764) /Source="Nicolas_S_feature" /locus_tag="new_2987548_2987649_c" /HighExp="G150, LBGtran, LBGexp, Lbexp, dia0, G180, G135, Oxctl, LBGstat, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 1" /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S1104" promotor_-10 complement(2638753..2638772) /Source="Nicolas_upshift_promotors" /id="U2257" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2698 /SigmaFactorBS="cacgtttattttttgtgacattccttaaatttTATTTaaaaa caatttatttAATTGTATAATAGGTAAGGTttcatagggaggatggagatcccttttc a" /listShort="S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2638764) /Source="Nicolas_upshifts" /id="U2257" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2698 /SigmaFactorBS="cacgtttattttttgtgacattccttaaatttTATTTaaaaa caatttatttAATTGTATAATAGGTAAGGTttcatagggaggatggagatcccttttc a" /listShort="S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2638788..2638792) /Source="Nicolas_upshift_promotors" /id="U2257" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2698 /SigmaFactorBS="cacgtttattttttgtgacattccttaaatttTATTTaaaaa caatttatttAATTGTATAATAGGTAAGGTttcatagggaggatggagatcccttttc a" /listShort="S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2638846..2639823) /gene="accA" /locus_tag="BSU_29200" /old_locus_tag="BSU29200" /EC_number="6.4.1.2" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11133475, 12682299, 15066985; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetyl-CoA carboxylase (carboxyltransferase alpha subunit)" /protein_id="NP_390798.1" /db_xref="EnsemblGenomes-Gn:BSU29200" /db_xref="EnsemblGenomes-Tr:CAB14880" /db_xref="GOA:O34847" /db_xref="InterPro:IPR001095" /db_xref="InterPro:IPR011763" /db_xref="InterPro:IPR029045" /db_xref="SubtiList:BG12557" /db_xref="UniProtKB/Swiss-Prot:O34847" /translation="MAPRLEFEKPVIELQTKIAELKKFTQDSDMDLSAEIERLEDRLA KLQDDIYKNLKPWDRVQIARLADRPTTLDYIEHLFTDFFECHGDRAYGDDEAIVGGIA KFHGLPVTVIGHQRGKDTKENLVRNFGMPHPEGYRKALRLMKQADKFNRPIICFIDTK GAYPGRAAEERGQSEAIAKNLFEMAGLRVPVICIVIGEGGSGGALGLGVGNHLHMLEN STYSVISPEGAAALLWKDSSLAKKAAETMKITAPDLKELGIIDHMIKEVKGGAHHDVK LQASYMDETLKQSLKTLLKLSEEELVQQRYEKYKAIGKVSVEDQYIGVN*" /label="accA CDS" gene complement(2638846..2639823) /gene="accA" /locus_tag="BSU_29200" /old_locus_tag="BSU29200" /label="accA gene" downshifts complement(2638873) /Source="Nicolas_upshifts" /id="D1498" /incds=0 /nref=48 /ntot=176 /MaxReadThrough="5.40549" /MaxDrop="5.53933" /score="-3.96100458" /energy="-6.8" /TU="U2259,U2260,U2262,U2263" /idTUdmin="U2260" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" CDS complement(2639808..2640680) /gene="accD" /locus_tag="BSU_29210" /old_locus_tag="BSU29210" /EC_number="6.4.1.2" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11133475, 12682299, 14594796, 15066985; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetyl-CoA carboxylase (carboxyltransferase betasubunit)" /protein_id="NP_390799.2" /db_xref="EnsemblGenomes-Gn:BSU29210" /db_xref="EnsemblGenomes-Tr:CAB14881" /db_xref="GOA:C0SP93" /db_xref="InterPro:IPR000438" /db_xref="InterPro:IPR011762" /db_xref="InterPro:IPR029045" /db_xref="InterPro:IPR034733" /db_xref="SubtiList:BG13926" /db_xref="UniProtKB/Swiss-Prot:C0SP93" /translation="MLKDIFTKKKKYASVPSDQAKHDVPEGIMTKCPKCKKIMLTKEL DKNMRVCMNCDYHFPMNAKQRIESLMDEQSFEEFNQGMLSENPLGFPGYLEKLEKDRE KTSLNEAVVTGKGTIGGHPAVVAVMDSSFRMGSMGSVVGEKITLAIEKAKADKVPFII FTASGGARMQEGVLSLMQMAKTSSALKLFSEEQGLIISVMTHPTTGGVSASFASLGDY NFAEPGALIGFAGRRIIEQTIGEKLPEDFQTAEFLLKHGQLDAVIHRDDMKKTLENLL DMHQTGGDIEWLQD*" /label="accD CDS" gene complement(2639808..2640680) /gene="accD" /locus_tag="BSU_29210" /old_locus_tag="BSU29210" /label="accD gene" promotor_-35 2640642..2640647 /Source="Nicolas_upshift_promotors" /id="U2258" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1067 /SigmaFactorBS="ggaacatcgtgcttcgcttgatcagacggtacggaAGCATAc tttttctttttcgtGAATATATCCTTTAACAAAtgattacctcccttttgtgaagggt t" /listShort="S1105" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2640663..2640681 /Source="Nicolas_upshift_promotors" /id="U2258" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1067 /SigmaFactorBS="ggaacatcgtgcttcgcttgatcagacggtacggaAGCATAc tttttctttttcgtGAATATATCCTTTAACAAAtgattacctcccttttgtgaagggt t" /listShort="S1105" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2640667..2641841 /Source="Nicolas_S_feature" /locus_tag="new_2989552_2990726" /HighExp="S5, S8, S6, S7, C30, S4, C90, S3, T5.0H, BC" /AntisenseName="ytsJ" /AntisenseCor="-0.46008986922877199" /AntisenseRegPval="-14.8" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1105" upshifts 2640667 /Source="Nicolas_upshifts" /id="U2258" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1067 /SigmaFactorBS="ggaacatcgtgcttcgcttgatcagacggtacggaAGCATAc tttttctttttcgtGAATATATCCTTTAACAAAtgattacctcccttttgtgaagggt t" /listShort="S1105" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2640681..2640764) /Source="Nicolas_S_feature" /locus_tag="new_2989566_2989649_c" /HighExp="LBGstat, T4.0H, LBGtran, T5.0H, C30, dia15, M9-stat, Oxctl, LBGexp, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="1, 1, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1106" promotor_-10 complement(2640753..2640772) /Source="Nicolas_upshift_promotors" /id="U2259" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.675324675324675" /psig=1 /xcortree=2509 /SigmaFactorBS="gcacgtcatcgaataaaaagttgtcgaattgaGGATGacagc gtttgacaaaAAAAGTACAATAGTTTCGGTaaagttattagcaagtctatctgtttga t" /listShort="S1106, accD, accA, S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2640764) /Source="Nicolas_upshifts" /id="U2259" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.675324675324675" /psig=1 /xcortree=2509 /SigmaFactorBS="gcacgtcatcgaataaaaagttgtcgaattgaGGATGacagc gtttgacaaaAAAAGTACAATAGTTTCGGTaaagttattagcaagtctatctgtttga t" /listShort="S1106, accD, accA, S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2640766..2640918) /Source="Nicolas_S_feature" /locus_tag="new_2989651_2989803_c" /HighExp="Diami, BC, dia15, Sw, dia5, M40t90, H2O2, S2, G/S, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1107" promotor_-35 complement(2640788..2640792) /Source="Nicolas_upshift_promotors" /id="U2259" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.675324675324675" /psig=1 /xcortree=2509 /SigmaFactorBS="gcacgtcatcgaataaaaagttgtcgaattgaGGATGacagc gtttgacaaaAAAAGTACAATAGTTTCGGTaaagttattagcaagtctatctgtttga t" /listShort="S1106, accD, accA, S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2640920..2641014) /Source="Nicolas_S_feature" /locus_tag="new_2989805_2989899_c" /HighExp="dia15, LBGtran, LBGstat, Diami, LoTm, C90, GM 120, MG 60, M/G, M40t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1108" downshifts complement(2640963) /Source="Nicolas_upshifts" /id="D1499" /incds=0 /nref=52 /ntot=158 /MaxReadThrough="7.72399" /MaxDrop="4.5863" /score="-3.96100458" /energy="-6.8" /TU="U2260,U2262,U2263" /idTUdmin="U2260" /TUdmin="-2178" /isTUend="FALSE" /label="downshifts" CDS complement(2641015..2642247) /gene="maeB" /locus_tag="BSU_29220" /old_locus_tag="BSU29220" /EC_number="1.1.1.40" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:16788182, 22740702, 23136871, 24325460, 25393291" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16788182, 22740702, 23136871, 24325460, 25393291; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADP-dependent malic enzyme (conversion of malate into pyruvate, anabolic)" /protein_id="NP_390800.1" /db_xref="EnsemblGenomes-Gn:BSU29220" /db_xref="EnsemblGenomes-Tr:CAB14882" /db_xref="GOA:O34962" /db_xref="InterPro:IPR001891" /db_xref="InterPro:IPR012301" /db_xref="InterPro:IPR012302" /db_xref="InterPro:IPR015884" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR037062" /db_xref="SubtiList:BG13922" /db_xref="UniProtKB/Swiss-Prot:O34962" /translation="MSLREEALHLHKVNQGKLESKSKVEVRNAKDLSLAYSPGVAEPC KDIHEDINKVYDYTMKGNMVAVVTDGTAVLGLGNIGPEAALPVMEGKAVLFKSFAGVD AFPIALNTNDVDKIVETVKLLEPTFGGVNLEDIAAPNCFIIEERLKKETNIPVFHDDQ HGTAIVTVAGLVNALKLSGKSMSSIKVVANGAGAAGIAIIKLLHHYGVRDIVMCDSKG AIYEGRPNGMNDVKNEVAKFTNQDRKDGSLKDVIVDADVFIGVSVAGALTKEMVQSMA KDPIIFAMANPNPEIMPEDAREAGASVVGTGRSDFPNQVNNVLAFPGIFRGALDVRAT HINEEMKIAAVEAIASLVSEDELSADYVIPAPFDKRVAPAVAKAVAKAAMETGVARIT VDPEEVAEKTRKLTIIGE*" /label="maeB CDS" gene complement(2641015..2642247) /gene="maeB" /locus_tag="BSU_29220" /old_locus_tag="BSU29220" /label="maeB gene" S_feature complement(2642248..2642364) /Source="Nicolas_S_feature" /locus_tag="new_2991133_2991249_c" /HighExp="dia15, Diami, LBGstat, H2O2, LBGtran, dia5, M40t45, Lbtran, LPhT, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1109" promotor_-10 complement(2642352..2642371) /Source="Nicolas_upshift_promotors" /id="U2260" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=1981 /SigmaFactorBS="agctgttgggtcaaaaaaacgtcgttttaaaaCAGTGGTAac gattcgcttttTGTTATACAATTGGAGCAATtatgtgatcctgtttaaatattcagat a" /listShort="S1109, ytsJ, S1108, S1107, S1106, accD, accA" /listLong="S1104, pfkA, pyk, S1103, ytzA" /label="promotor_-10" upshifts complement(2642364) /Source="Nicolas_upshifts" /id="U2260" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=1981 /SigmaFactorBS="agctgttgggtcaaaaaaacgtcgttttaaaaCAGTGGTAac gattcgcttttTGTTATACAATTGGAGCAATtatgtgatcctgtttaaatattcagat a" /listShort="S1109, ytsJ, S1108, S1107, S1106, accD, accA" /listLong="S1104, pfkA, pyk, S1103, ytzA" /label="upshifts" CDS complement(2642384..2645731) /gene="dnaEC" /locus_tag="BSU_29230" /old_locus_tag="BSU29230" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:9799485, 9822387, 10354411, 14593098, 20122408, 22333191, 24106089, 29078353" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9799485, 9822387, 10354411, 14593098, 20122408, 22333191, 24106089, 29078353; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA polymerase III (alpha subunit), DnaE3" /protein_id="NP_390801.1" /db_xref="EnsemblGenomes-Gn:BSU29230" /db_xref="EnsemblGenomes-Tr:CAB14883" /db_xref="GOA:O34623" /db_xref="InterPro:IPR003141" /db_xref="InterPro:IPR004013" /db_xref="InterPro:IPR004365" /db_xref="InterPro:IPR004805" /db_xref="InterPro:IPR011708" /db_xref="InterPro:IPR016195" /db_xref="InterPro:IPR029460" /db_xref="SubtiList:BG12583" /db_xref="UniProtKB/Swiss-Prot:O34623" /translation="MSFVHLQVHSGYSLLNSAAAVEELVSEADRLGYASLALTDDHVM YGAIQFYKACKARGINPIIGLTASVFTDDSELEAYPLVLLAKSNTGYQNLLKISSVLQ SKSKGGLKPKWLHSYREGIIAITPGEKGYIETLLEGGLFEQAAQASLEFQSIFGKGAF YFSYQPFKGNQVLSEQILKLSEETGIPVTATGDVHYIRKEDKAAYRCLKAIKAGEKLT DAPAEDLPDLDLKPLEEMQNIYREHPEALQASVEIAEQCRVDVSLGQTRLPSFPTPDG TSADDYLTDICMEGLRSRFGKPDERYLRRLQYELDVIKRMKFSDYFLIVWDFMKHAHE KGIVTGPGRGSAAGSLVAYVLYITDVDPIKHHLLFERFLNPERVSMPDIDIDFPDTRR DEVIQYVQQKYGAMHVAQIITFGTLAAKAALRDVGRVFGVSPKEADQLAKLIPSRPGM TLDEARQQSPQLDKRLRESSLLQQVYSIARKIEGLPRHASTHAAGVVLSEEPLTDVVP LQEGHEGIYLTQYAMDHLEDLGLLKMDFLGLRNLTLIESITSMIEKEENIKIDLSSIS YSDDKTFSLLSKGDTTGIFQLESAGMRSVLKRLKPSGLEDIVAVNALYRPGPMENIPL FIDRKHGRAPVHYPHEDLRSILEDTYGVIVYQEQIMMIASRMAGFSLGEADLLRRAVS KKKKEILDRERSHFVEGCLKKEYSVDTANEVYDLIVKFANYGFNRSHAVAYSMIGCQL AYLKAHYPLYFMCGLLTSVIGNEDKISQYLYEAKGSGIRILPPSVNKSSFPFTVENGS VRYSLRAIKSVGVSAVKDIYKARKEKPFEDLFDFCFRVPSKSVNRKMLEALIFSGAMD EFGQNRATLLASIDVALEHAELFAADDDQMGLFLDESFSIKPKYVETEELPLVDLLAF EKETLGIYFSNHPLSAFRKQLTAQGAVSILQAQRAVKRQLSLGVLLSKIKTIRTKTGQ NMAFLTLSDETGEMEAVVFPEQFRQLSPVLREGALLFTAGKCEVRQDKIQFIMSRAEL LEDMDAEKAPSVYIKIESSQHSQEILAKIKRILLEHKGETGVYLYYERQKQTIKLPES FHINADHQVLYRLKELLGQKNVVLKQW*" /label="dnaEC CDS" gene complement(2642384..2645731) /gene="dnaEC" /locus_tag="BSU_29230" /old_locus_tag="BSU29230" /label="dnaEC gene" promotor_-35 complement(2642385..2642392) /Source="Nicolas_upshift_promotors" /id="U2260" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98101898101898" /psig=1 /xcortree=1981 /SigmaFactorBS="agctgttgggtcaaaaaaacgtcgttttaaaaCAGTGGTAac gattcgcttttTGTTATACAATTGGAGCAATtatgtgatcctgtttaaatattcagat a" /listShort="S1109, ytsJ, S1108, S1107, S1106, accD, accA" /listLong="S1104, pfkA, pyk, S1103, ytzA" /label="promotor_-35" promotor_-35 2643396..2643405 /Source="Nicolas_upshift_promotors" /id="U2261" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1681 /SigmaFactorBS="aacggaaaactgcttttattcactgacggaggaaggataCGA ATCCCGCtcccctttgctTCGTAAAGATATTGAGagattttatcctcattgccaatga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2643417..2643432 /Source="Nicolas_upshift_promotors" /id="U2261" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1681 /SigmaFactorBS="aacggaaaactgcttttattcactgacggaggaaggataCGA ATCCCGCtcccctttgctTCGTAAAGATATTGAGagattttatcctcattgccaatga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2643417 /Source="Nicolas_upshifts" /id="U2261" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1681 /SigmaFactorBS="aacggaaaactgcttttattcactgacggaggaaggataCGA ATCCCGCtcccctttgctTCGTAAAGATATTGAGagattttatcctcattgccaatga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2643605..2643624) /Source="Nicolas_upshift_promotors" /id="U2262" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.973026973026973" /psig=1 /xcortree=2017 /SigmaFactorBS="aaaagaaaaaagaaatcctggacagagagcgaagccattTTG TTGAAgggtgcttaaaaaAGGAGTATTCTGTAGACACTgcaaatgaggtctacgattt a" /listShort="S1109, ytsJ, S1108, S1107, S1106, accD, accA, S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2643624) /Source="Nicolas_upshifts" /id="U2262" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.973026973026973" /psig=1 /xcortree=2017 /SigmaFactorBS="aaaagaaaaaagaaatcctggacagagagcgaagccattTTG TTGAAgggtgcttaaaaaAGGAGTATTCTGTAGACACTgcaaatgaggtctacgattt a" /listShort="S1109, ytsJ, S1108, S1107, S1106, accD, accA, S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2643638..2643645) /Source="Nicolas_upshift_promotors" /id="U2262" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.973026973026973" /psig=1 /xcortree=2017 /SigmaFactorBS="aaaagaaaaaagaaatcctggacagagagcgaagccattTTG TTGAAgggtgcttaaaaaAGGAGTATTCTGTAGACACTgcaaatgaggtctacgattt a" /listShort="S1109, ytsJ, S1108, S1107, S1106, accD, accA, S1104, pfkA, pyk, S1103, ytzA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2645762..2645781) /Source="Nicolas_upshift_promotors" /id="U2263" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2091 /SigmaFactorBS="agctttcaggacaagtatgatgatgagtcaaaaaagaaCATT TGTTtcttttggaaaccGGCCTTATAATGAAGGAAGAaatggatcgtaatgagaaaga g" /listShort="dnaE, S1109, ytsJ, S1108, S1107, S1106, accD, accA" /listLong="S1104, pfkA, pyk, S1103, ytzA" /label="promotor_-10" upshifts complement(2645780) /Source="Nicolas_upshifts" /id="U2263" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2091 /SigmaFactorBS="agctttcaggacaagtatgatgatgagtcaaaaaagaaCATT TGTTtcttttggaaaccGGCCTTATAATGAAGGAAGAaatggatcgtaatgagaaaga g" /listShort="dnaE, S1109, ytsJ, S1108, S1107, S1106, accD, accA" /listLong="S1104, pfkA, pyk, S1103, ytzA" /label="upshifts" promotor_-35 complement(2645795..2645802) /Source="Nicolas_upshift_promotors" /id="U2263" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2091 /SigmaFactorBS="agctttcaggacaagtatgatgatgagtcaaaaaagaaCATT TGTTtcttttggaaaccGGCCTTATAATGAAGGAAGAaatggatcgtaatgagaaaga g" /listShort="dnaE, S1109, ytsJ, S1108, S1107, S1106, accD, accA" /listLong="S1104, pfkA, pyk, S1103, ytzA" /label="promotor_-35" promotor_-35 2645820..2645825 /Source="Nicolas_upshift_promotors" /id="U2264" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=988 /SigmaFactorBS="aggccggtttccaaaagaaacaaatgttcttttttgactcat cATCATActtgtcctgaaagctCAATATGATATAAAAGGTGaggtgataaagatggat c" /listShort="ytrH, ytrI" /listLong="ytzJ, S1110, S1111, S1112, ytpI, S1114" /label="promotor_-35" upshifts 2645837 /Source="Nicolas_upshifts" /id="U2264" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=988 /SigmaFactorBS="aggccggtttccaaaagaaacaaatgttcttttttgactcat cATCATActtgtcctgaaagctCAATATGATATAAAAGGTGaggtgataaagatggat c" /listShort="ytrH, ytrI" /listLong="ytzJ, S1110, S1111, S1112, ytpI, S1114" /label="upshifts" promotor_-10 2645841..2645859 /Source="Nicolas_upshift_promotors" /id="U2264" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=988 /SigmaFactorBS="aggccggtttccaaaagaaacaaatgttcttttttgactcat cATCATActtgtcctgaaagctCAATATGATATAAAAGGTGaggtgataaagatggat c" /listShort="ytrH, ytrI" /listLong="ytzJ, S1110, S1111, S1112, ytpI, S1114" /label="promotor_-10" CDS 2645871..2646212 /gene="ytrH" /locus_tag="BSU_29239" /old_locus_tag="BSU29239" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12662922, 15547282, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12662922, 15547282, 26735940; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="membrane protein involved in a sporulation process" /protein_id="YP_003097771.1" /db_xref="EnsemblGenomes-Gn:BSU29239" /db_xref="EnsemblGenomes-Tr:CAX52677" /db_xref="GOA:C0H3P8" /db_xref="InterPro:IPR025689" /db_xref="UniProtKB/Swiss-Prot:C0H3P8" /translation="MDQEAGFMVNFINSYFIALGVLIGGALIGGLGAYLAGEPPLTAI TKLANRLKIWALVAAIGGTFDAVYSFERGILEGNTRDIFKQLLLIISAMGGAQSGWLI ISWLTQEHLSS*" /label="ytrH CDS" gene 2645871..2646212 /gene="ytrH" /locus_tag="BSU_29239" /old_locus_tag="BSU29239" /label="ytrH gene" CDS 2646209..2646712 /gene="ytrI" /locus_tag="BSU_29240" /old_locus_tag="BSU29240" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12662922, 15547282, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12662922, 15547282, 26735940; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="protein involved in sporulation" /protein_id="NP_390802.3" /db_xref="EnsemblGenomes-Gn:BSU29240" /db_xref="EnsemblGenomes-Tr:CAB14884" /db_xref="GOA:O34460" /db_xref="SubtiList:BG13917" /db_xref="UniProtKB/Swiss-Prot:O34460" /translation="MRVPQHYKKPGWQRFFAGMMCGAVISWFFFLFTYGTFQEEQVSL IEKQKEHVKDLNNQISIYQEDLHKLNEDNKRKLLIQSVSVKLLNGDKYKISQPDKTKF EEHVKDDISEVITKDIESVYQTKDLLKRTIENKVYMINEKKYEATVRELIIYTRLTVE LEISFAT*" /label="ytrI CDS" gene 2646209..2646712 /gene="ytrI" /locus_tag="BSU_29240" /old_locus_tag="BSU29240" /label="ytrI gene" promotor_-35 2646745..2646748 /Source="Nicolas_upshift_promotors" /id="U2265" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.487512487512487" /psig="0.973026973026973" /xcortree=529 /SigmaFactorBS="cgccacataattatggattttttttaaattctccaaacttct GTCGctttttcccattctTTTTTATAAACTATATGTGAggcttaatggcgaaaggaag g" /listShort="ytzJ, S1110, S1111, S1112, ytpI, S1114" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2646763..2646782 /Source="Nicolas_upshift_promotors" /id="U2265" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.487512487512487" /psig="0.973026973026973" /xcortree=529 /SigmaFactorBS="cgccacataattatggattttttttaaattctccaaacttct GTCGctttttcccattctTTTTTATAAACTATATGTGAggcttaatggcgaaaggaag g" /listShort="ytzJ, S1110, S1111, S1112, ytpI, S1114" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2646763 /Source="Nicolas_upshifts" /id="U2265" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.487512487512487" /psig="0.973026973026973" /xcortree=529 /SigmaFactorBS="cgccacataattatggattttttttaaattctccaaacttct GTCGctttttcccattctTTTTTATAAACTATATGTGAggcttaatggcgaaaggaag g" /listShort="ytzJ, S1110, S1111, S1112, ytpI, S1114" /GFF_Attribute="listLong" /label="upshifts" CDS 2646814..2647005 /gene="ytzJ" /locus_tag="BSU_29249" /old_locus_tag="BSU29249" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative sporulation-related conserved protein" /protein_id="YP_003097772.1" /db_xref="EnsemblGenomes-Gn:BSU29249" /db_xref="EnsemblGenomes-Tr:CAX52678" /db_xref="UniProtKB/Swiss-Prot:C0H3P9" /translation="MEVYSDRQLAKDQAARLRQGFSAYAETNSLASLIKKELQSHNLQ VYEDLTDFGCWFIPVTDEH*" /label="ytzJ CDS" gene 2646814..2647005 /gene="ytzJ" /locus_tag="BSU_29249" /old_locus_tag="BSU29249" /label="ytzJ gene" downshifts complement(2646815) /Source="Nicolas_upshifts" /id="D1500" /incds=0 /nref=1 /ntot=5 /MaxReadThrough="2.45109" /MaxDrop="3.19151" /score="-1.37123732" /energy="-6.5" /TU="NA" /idTUdmin="U2268" /TUdmin=220 /isTUend="FALSE" /label="downshifts" downshifts 2646981 /Source="Nicolas_upshifts" /id="D1501" /incds=0 /nref=15 /ntot=107 /MaxReadThrough="6.88261" /MaxDrop="6.74738" /score="-8.58003897" /energy="-4" /TU="U2265" /idTUdmin="U2264" /TUdmin=242 /isTUend="FALSE" /label="downshifts" CDS complement(2647023..2647964) /gene="nrnA" /locus_tag="BSU_29250" /old_locus_tag="BSU29250" /EC_number="3.1.3.7" /EC_number="3.1.-.-" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17586819, 19553197, 22102036, 26735940, 28894100" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17586819, 19553197, 22102036, 26735940, 28894100; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nanoRNase (oligoribonuclease) (3'->5'short substrates, 5'->3' long substrates), 3',5'-bisphosphate nucleotidase" /protein_id="NP_390803.1" /db_xref="EnsemblGenomes-Gn:BSU29250" /db_xref="EnsemblGenomes-Tr:CAB14885" /db_xref="GOA:O34600" /db_xref="InterPro:IPR001667" /db_xref="InterPro:IPR003156" /db_xref="PDB:5IPP" /db_xref="PDB:5IUF" /db_xref="PDB:5IZO" /db_xref="PDB:5J21" /db_xref="SubtiList:BG13910" /db_xref="UniProtKB/Swiss-Prot:O34600" /translation="MKTELIRTISLYDTIILHRHVRPDPDAYGSQCGLTEILRETYPE KNIFAVGTPEPSLSFLYSLDEVDNETYEGALVIVCDTANQERIDDQRYPSGAKLMKID HHPNEDPYGDLLWVDTSASSVSEMIYELYLEGKEHGWKLNTKAAELIYAGIVGDTGRF LFPNTTEKTLKYAGELIQYPFSSSELFNQLYETKLNVVKLNGFIFQNVSLSENGAASV FIKKDTLEKFGTTASEASQLVGTLGNISGIRAWVFFVEEDDQIRVRFRSKGPVINGLA RKYNGGGHPLASGASIYSWDEADRILADLETLCKEHE*" /label="nrnA CDS" gene complement(2647023..2647964) /gene="nrnA" /locus_tag="BSU_29250" /old_locus_tag="BSU29250" /label="nrnA gene" S_feature 2647026..2647397 /Source="Nicolas_S_feature" /locus_tag="new_2995911_2996282" /HighExp="Lbstat, S2, M0t90, M40t90, nit, ferm, S3, BT, M9-stat, S0" /AntisenseName="nrnA" /AntisenseCor="-0.77648424268923499" /AntisenseRegPval="-54.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.973" /TUlongSig="SigEF" /TUlongPSig="0.994" /label="S1110" downshifts complement(2647058) /Source="Nicolas_upshifts" /id="D1502" /incds=0 /nref=25 /ntot=163 /MaxReadThrough="3.12169" /MaxDrop="3.09205" /score="22.5196409" /energy="-7.9" /TU="U2268" /idTUdmin="U2269" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 2647366..2647375 /Source="Nicolas_upshift_promotors" /id="U2266" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1354 /SigmaFactorBS="gacacattttgaaagataaagccgttaAGCTTCACCAcattc agttttgtTTCATACAATTGATTAAATAactctgaggaagagaatggatactgaatga g" /listShort="S1111, S1112, ytpI, S1114" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2647389..2647408 /Source="Nicolas_upshift_promotors" /id="U2266" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1354 /SigmaFactorBS="gacacattttgaaagataaagccgttaAGCTTCACCAcattc agttttgtTTCATACAATTGATTAAATAactctgaggaagagaatggatactgaatga g" /listShort="S1111, S1112, ytpI, S1114" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2647399..2647793 /Source="Nicolas_S_feature" /locus_tag="new_2996284_2996678" /HighExp="Lbstat, S2, S7, S8, S6, nit, ferm, M0t90, BT, M40t90" /AntisenseName="nrnA" /AntisenseCor="-0.85531073541330804" /AntisenseRegPval="-77.5" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA" /TUshortPSig="1, 0.973" /TUlongSig="SigEF" /TUlongPSig="0.994" /label="S1111" upshifts 2647399 /Source="Nicolas_upshifts" /id="U2266" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1354 /SigmaFactorBS="gacacattttgaaagataaagccgttaAGCTTCACCAcattc agttttgtTTCATACAATTGATTAAATAactctgaggaagagaatggatactgaatga g" /listShort="S1111, S1112, ytpI, S1114" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2647755..2647761 /Source="Nicolas_upshift_promotors" /id="U2267" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.698301698301698" /psig="0.698301698301698" /xcortree=742 /SigmaFactorBS="atgacaagtgcgccttcataTGTTTCAttgtccacctcatca AGGGAATATAAGAAAGAGAGggacggttcaggcgtgccgaccgcaaaaatattttttt c" /listShort="S1112, ytpI, S1114" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2647777..2647796 /Source="Nicolas_upshift_promotors" /id="U2267" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.698301698301698" /psig="0.698301698301698" /xcortree=742 /SigmaFactorBS="atgacaagtgcgccttcataTGTTTCAttgtccacctcatca AGGGAATATAAGAAAGAGAGggacggttcaggcgtgccgaccgcaaaaatattttttt c" /listShort="S1112, ytpI, S1114" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2647795..2648094 /Source="Nicolas_S_feature" /locus_tag="new_2996680_2996979" /HighExp="Lbstat, S8, S7, S6, S2, Etha, nit, ferm, BT, M0t90" /AntisenseName="nrnA" /AntisenseCor="-0.84034645112995598" /AntisenseRegPval="-72.2" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigK, SigA" /TUshortPSig="0.698, 1, 0.973" /TUlongSig="SigEF" /TUlongPSig="0.994" /label="S1112" upshifts 2647795 /Source="Nicolas_upshifts" /id="U2267" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.698301698301698" /psig="0.698301698301698" /xcortree=742 /SigmaFactorBS="atgacaagtgcgccttcataTGTTTCAttgtccacctcatca AGGGAATATAAGAAAGAGAGggacggttcaggcgtgccgaccgcaaaaatattttttt c" /listShort="S1112, ytpI, S1114" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2647983..2648002) /Source="Nicolas_upshift_promotors" /id="U2268" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.515484515484515" /psig="0.995004995004995" /xcortree=2384 /SigmaFactorBS="attttatacaaaaacgggcttggttttgacgttatttttCTT TtccgtcggcagagaATGTGATTTAATGAATAAAAacaataaaggagtatcaaatgaa a" /listShort="nrnA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2647999) /Source="Nicolas_upshifts" /id="U2268" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.515484515484515" /psig="0.995004995004995" /xcortree=2384 /SigmaFactorBS="attttatacaaaaacgggcttggttttgacgttatttttCTT TtccgtcggcagagaATGTGATTTAATGAATAAAAacaataaaggagtatcaaatgaa a" /listShort="nrnA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2648001..2648415) /Source="Nicolas_S_feature" /locus_tag="new_2996886_2997300_c" /HighExp="LBGtran, HiTm, G180, G135, G150, Lbtran, LBGexp, Mt0, Paraq, dia0" /AntisenseName="ytpI" /AntisenseCor="-0.70134306018551296" /AntisenseRegPval="-40.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1113" promotor_-35 complement(2648017..2648020) /Source="Nicolas_upshift_promotors" /id="U2268" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.515484515484515" /psig="0.995004995004995" /xcortree=2384 /SigmaFactorBS="attttatacaaaaacgggcttggttttgacgttatttttCTT TtccgtcggcagagaATGTGATTTAATGAATAAAAacaataaaggagtatcaaatgaa a" /listShort="nrnA" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2648095..2648397 /gene="ytpI" /locus_tag="BSU_29260" /old_locus_tag="BSU29260" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390804.1" /db_xref="EnsemblGenomes-Gn:BSU29260" /db_xref="EnsemblGenomes-Tr:CAB14886" /db_xref="GOA:O34922" /db_xref="InterPro:IPR025618" /db_xref="SubtiList:BG13902" /db_xref="UniProtKB/Swiss-Prot:O34922" /translation="MLVLVFLIGLSACFYVYYKVKGVRAKPSLAKEICSAKSSMALGS LVLFYGLNQMILFHSVLTLVIGGIFIVIGAGSAWAGYKAFRHYNPLHAKEAERDHA*" /label="ytpI CDS" gene 2648095..2648397 /gene="ytpI" /locus_tag="BSU_29260" /old_locus_tag="BSU29260" /label="ytpI gene" S_feature 2648398..2650193 /Source="Nicolas_S_feature" /locus_tag="new_2997283_2999078" /HighExp="S8, S6, S7, Lbstat, B36, nit, ferm, T1.0H, C30, S5" /AntisenseName="ytoI" /AntisenseCor="-0.55304378374907204" /AntisenseRegPval="-22.2" /CDS_PredictionProba="0.89152299999999995" /TUshortSig="SigB, SigK, SigA" /TUshortPSig="0.698, 1, 0.973" /TUlongSig="SigEF" /TUlongPSig="0.994" /label="S1114" CDS complement(2648416..2649735) /gene="ytoI" /locus_tag="BSU_29270" /old_locus_tag="BSU29270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 26296725" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390805.1" /db_xref="EnsemblGenomes-Gn:BSU29270" /db_xref="EnsemblGenomes-Tr:CAB14887" /db_xref="GOA:O34921" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR006683" /db_xref="InterPro:IPR010766" /db_xref="InterPro:IPR028979" /db_xref="InterPro:IPR029069" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13897" /db_xref="UniProtKB/Swiss-Prot:O34921" /translation="MATKHEQILTYIDSLPVGEKISVRRIAKEMKVSEGTAYRAIKEA ENKGFVSTIERVGTIRIEQKKKENIEKLTYAEVVNVIDGQVLGGRAGLHKTLNKFVIG AMELDAMMRYTAAGNLLIVGNRINAHRQALEAGAAVLVTGGFNTDDSIVQLADELELP ILSTSYDTFTVAAMINRAIYDQLIKKEIVLVEDILTPADRTVYLSPKDKLEKWYEKNF ETGHGRFPVVDDQMKIHGILTSKDIAGHDRNASIEKVMTKNPVTVIGKTSVASAAQMM VWEGIEVLPVTDGHQKLIGMISRQDVLKALQMIQKQPQVGEKLDDIVSRGFKDEGDDK EDQTVYEYEVTPQMTNQLGTISYGVFTTILTQAANRFLRSKKRGELVIESITIFFLKP VQMESVIEVKPRILEAGRKFGKMEVEVHSQGHIVSKAMLMVQLMERS*" /label="ytoI CDS" gene complement(2648416..2649735) /gene="ytoI" /locus_tag="BSU_29270" /old_locus_tag="BSU29270" /label="ytoI gene" promotor_-10 complement(2649761..2649780) /Source="Nicolas_upshift_promotors" /id="U2269" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.491508491508492" /psig="0.993006993006993" /xcortree=2263 /SigmaFactorBS="ctgtaagaagccggtcgggcttcttttttattttccagcctc ATTGCGtataaatcctttgaAACCTTATAATAAAAACAAGaagactgtccttagaggt g" /listShort="ytoI, S1113, nrnA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2649782) /Source="Nicolas_upshifts" /id="U2269" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.491508491508492" /psig="0.993006993006993" /xcortree=2263 /SigmaFactorBS="ctgtaagaagccggtcgggcttcttttttattttccagcctc ATTGCGtataaatcctttgaAACCTTATAATAAAAACAAGaagactgtccttagaggt g" /listShort="ytoI, S1113, nrnA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2649795..2649800) /Source="Nicolas_upshift_promotors" /id="U2269" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.491508491508492" /psig="0.993006993006993" /xcortree=2263 /SigmaFactorBS="ctgtaagaagccggtcgggcttcttttttattttccagcctc ATTGCGtataaatcctttgaAACCTTATAATAAAAACAAGaagactgtccttagaggt g" /listShort="ytoI, S1113, nrnA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2649911..2650813) /gene="ytnM" /locus_tag="BSU_29280" /old_locus_tag="BSU29280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 23944997; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_390806.1" /db_xref="EnsemblGenomes-Gn:BSU29280" /db_xref="EnsemblGenomes-Tr:CAB14888" /db_xref="GOA:O34430" /db_xref="InterPro:IPR002781" /db_xref="SubtiList:BG13894" /db_xref="UniProtKB/Swiss-Prot:O34430" /translation="MKKLIVFAFIGLLSQLIDGSLGMAYGVTSTSLLLAFGITPAVAS ASVHLAEVVTTAASGVSHIKFGNVDKQTVYQLVIPGSIGAFLGAAFLSQLPGDVAKPY ISLFLLLLGGYVLIRFLFQYKPALEKKHVPLNRKQSIPLGVIAGFADATGGGGWGPVT TPILLSRKGLSPRKVVGTVDTSEFAIAVSATAGFLISLGWEDVNWLWVFSLMAGGIIA APIAAWLVQKFHPQLMGVLVGGFIILVNARTLINEWIANTAVHPLIYTAIGAIWLSAV LFVLSKIGNRNIVKTAVDVHLKEK*" /label="ytnM CDS" gene complement(2649911..2650813) /gene="ytnM" /locus_tag="BSU_29280" /old_locus_tag="BSU29280" /label="ytnM gene" CDS complement(2650832..2652082) /gene="sndA" /locus_tag="BSU_29290" /old_locus_tag="BSU29290" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10588044, 10939241, 11423008, 16109943, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10588044, 10939241, 11423008, 16109943, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="S-alkyl-N-acetyl-metabolite deacetylase" /protein_id="NP_390807.1" /db_xref="EnsemblGenomes-Gn:BSU29290" /db_xref="EnsemblGenomes-Tr:CAB14889" /db_xref="GOA:O34980" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR017439" /db_xref="InterPro:IPR033846" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG12596" /db_xref="UniProtKB/Swiss-Prot:O34980" /translation="MSLDYWRNIEGSYPYQTTGNDILTLKEESNPVNLSTLEKQLIGI RRHLHQYPELSKEEFETTAFIKKCLKEKGIQIRPTALKTGVFADIAGESEGPAIALRA DIDALPIEEKTGLPYASKHKGIMHACGHDFHTAALLGAAFLLKENQDSLKGKIRLLFQ PAEEAGAGATKVIEDGQLDGIDAVIGLHNKPDIAVGTVGLKTGPLMAAVDRFKVEIEG KGAHAALPHNGFDPIIGASQLIVALQTIVSRNVNPLQSAILTVGKINGGSTWNVIPDT VVIEGTVRTFDSEVRNQVKQRFFAVTEQISAAFSLKANVKWHSGPPPLCNDEAITGLV RDAAHKAKLQVIDPAPSTAGEDFAYYLEHIPGSFAFFGTDGDHDWHHPAFTIDETAII KASYFLYESAKRLLDSNEESKISD*" /label="sndA CDS" gene complement(2650832..2652082) /gene="sndA" /locus_tag="BSU_29290" /old_locus_tag="BSU29290" /label="sndA gene" CDS complement(2652100..2652792) /gene="ribR" /locus_tag="BSU_29300" /old_locus_tag="BSU29300" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 15668000, 16109943, 17590224, 23944997, 26494285" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 15668000, 16109943, 17590224, 23944997, 26494285; Product type r: regulator" /codon_start=1 /transl_table=11 /product="FMN-riboswitch-binding activator of rib genes" /protein_id="NP_390808.1" /db_xref="EnsemblGenomes-Gn:BSU29300" /db_xref="EnsemblGenomes-Tr:CAB14890" /db_xref="GOA:P94465" /db_xref="InterPro:IPR015865" /db_xref="InterPro:IPR023465" /db_xref="InterPro:IPR023468" /db_xref="SubtiList:BG11969" /db_xref="UniProtKB/Swiss-Prot:P94465" /translation="MTIIAGTVVKGKQLGRKLGFPTANVDAKIHGLRNGVYGVLATVN HQFHLGVMNIGVKPTVGSNLEKTLEIFLFDFHRDIYGEKIECSILFKIREERRFDSLE SLTKQIKKDISCVAKRFELIGIMAPNKKESLLSHQELNLPDLCFYKKCNNLYGVNRGV YNVIDNWFFEYGITQVAYRRIYILSFLSFLKEDNPKVSSKYIRFGAGGLADKLNRFIS SYVEESEENILG*" /label="ribR CDS" gene complement(2652100..2652792) /gene="ribR" /locus_tag="BSU_29300" /old_locus_tag="BSU29300" /label="ribR gene" CDS complement(2652839..2654167) /gene="cmoJ" /locus_tag="BSU_29310" /old_locus_tag="BSU29310" /EC_number="1.14.-.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 16109943, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 16109943, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="monooxygenase (S-alkyl substrates)" /protein_id="NP_390809.1" /db_xref="EnsemblGenomes-Gn:BSU29310" /db_xref="EnsemblGenomes-Tr:CAB14891" /db_xref="GOA:O34974" /db_xref="InterPro:IPR011251" /db_xref="InterPro:IPR016215" /db_xref="InterPro:IPR036661" /db_xref="PDB:1TVL" /db_xref="PDB:1YW1" /db_xref="SubtiList:BG13893" /db_xref="UniProtKB/Swiss-Prot:O34974" /translation="MTRADFIQFGAMIHGVGGTTDGWRHPDVDPSASTNIEFYMKKAQ TAEKGLFSFIFIADGLFISEKSIPHFLNRFEPITILSALASVTKNIGLVGTFSTSFTE PFTISRQLMSLDHISGGRAGWNLVTSPQEGAARNHSKSNLPEHTERYEIAQEHLDVVR GLWNSWEHDAFIHNKKTGQFFDQAKLHRLNHKGKYFQVEGPLNIGRSKQGEPVVFQAG SSETGRQFAAKNADAIFTHSNSLEETKAFYADVKSRAADEGRDPSSVRIFPGISPIVA DTEEEAEKKYREFAELIPIENAVTYLARFFDDYDLSVYPLDEPFPDIGDVGKNAFQST TDRIKREAKARNLTLREVAQEMAFPRTLFIGTPERVASLIETWFNAEAADGFIVGSDI PGTLDAFVEKVIPILQERGLYRQDYRGGTLRENLGLGIPQHQSVLHSSHH*" /label="cmoJ CDS" gene complement(2652839..2654167) /gene="cmoJ" /locus_tag="BSU_29310" /old_locus_tag="BSU29310" /label="cmoJ gene" CDS complement(2654164..2654445) /gene="cmoI" /locus_tag="BSU_29320" /old_locus_tag="BSU29320" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 16109943, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 16109943, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="redoxin" /protein_id="NP_390810.1" /db_xref="EnsemblGenomes-Gn:BSU29320" /db_xref="EnsemblGenomes-Tr:CAB14892" /db_xref="GOA:O34639" /db_xref="InterPro:IPR002109" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG13892" /db_xref="UniProtKB/Swiss-Prot:O34639" /translation="MSDVVNIVVWSKKGCSYCEEVKNYLNEKGFPFQNIDVSEKEKLR DILQVKYGVRHVPVVEIGRGNQYQGITEIGIEHLDLALANHAQIKEAKR*" /label="cmoI CDS" gene complement(2654164..2654445) /gene="cmoI" /locus_tag="BSU_29320" /old_locus_tag="BSU29320" /label="cmoI gene" CDS complement(2654460..2655464) /gene="cmoO" /locus_tag="BSU_29330" /old_locus_tag="BSU29330" /EC_number="1.14.-.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9836433, 10939241, 11423008, 16109943, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9836433, 10939241, 11423008, 16109943, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="monooxygenase (S-alkyl substrates)" /protein_id="NP_390811.1" /db_xref="EnsemblGenomes-Gn:BSU29330" /db_xref="EnsemblGenomes-Tr:CAB14893" /db_xref="GOA:O34846" /db_xref="InterPro:IPR011251" /db_xref="InterPro:IPR019949" /db_xref="InterPro:IPR036661" /db_xref="SubtiList:BG13888" /db_xref="UniProtKB/Swiss-Prot:O34846" /translation="MIRLSILDQSLIGEGETAADTLQHTVKLAQMAEECGYHRFWVAE HHNNDEIAGSAPEVLLGYLAASTRKIRLASGGVMLQHYSSYKVAEQFHLLSALAPGRI DLGVGKAPGGFQLSTDALQAEYKKPVRQFDEKLEELTHFVRDDFPDTHRYAALRPRPQ VDRKPGIFLLGGSTESAISAAKLGISFVFAYFINGEEEVLKEARRAFDAHLPPGSEAE FHLAPAVFAAHTKEEAEKHIVSRESIKVVLKDGRKVNVGSREQAEAYLENVTEPYDII VQKTGIIAGTKEEVAEELTRLSGTYKINDFVIFTPIKNAVEKQLSYQLLSDAVLAAKR *" /label="cmoO CDS" gene complement(2654460..2655464) /gene="cmoO" /locus_tag="BSU_29330" /old_locus_tag="BSU29330" /label="cmoO gene" CDS complement(2655461..2656240) /gene="tcyN" /locus_tag="BSU_29340" /old_locus_tag="BSU29340" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 15262924, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 15262924, 23944997; Product type t: transporter" /codon_start=1 /transl_table=11 /product="sulfur-containing amino-acid ABC transporter (ATP-binding protein)" /protein_id="NP_390812.1" /db_xref="EnsemblGenomes-Gn:BSU29340" /db_xref="EnsemblGenomes-Tr:CAB14894" /db_xref="GOA:O34900" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030679" /db_xref="SubtiList:BG12604" /db_xref="UniProtKB/Swiss-Prot:O34900" /translation="MIEIKNIHKQFGIHHVLKGINLTVRKGEVVTIIGPSGSGKTTFL RCLNLLERPDEGIISIHDKVINCRFPSKKEVHWLRKQTAMVFQQYHLFAHKTVIENVM EGLTIARKMRKQDAYAVAENELRKVGLQDKLNAYPSQLSGGQKQRVGIARALAIHPDV LLFDEPTAALDPELVGEVLEVMLEIVKTGATMIVVTHEMEFARRVSDQVVFMDEGVIV EQGTPEEVFRHTKKDRTRQFLRRVSPEYLFEPKEHIKEPVI*" /label="tcyN CDS" gene complement(2655461..2656240) /gene="tcyN" /locus_tag="BSU_29340" /old_locus_tag="BSU29340" /label="tcyN gene" CDS complement(2656237..2656944) /gene="tcyM" /locus_tag="BSU_29350" /old_locus_tag="BSU29350" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 15262924, 15849754, 16850406, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 15262924, 15849754, 16850406, 23944997; Product type t : transporter" /codon_start=1 /transl_table=11 /product="sulfur-containing amino acid ABC transporter (permease)" /protein_id="NP_390813.1" /db_xref="EnsemblGenomes-Gn:BSU29350" /db_xref="EnsemblGenomes-Tr:CAB14895" /db_xref="GOA:O34931" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR010065" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG13887" /db_xref="UniProtKB/Swiss-Prot:O34931" /translation="MQFDFPFIVSAMKEMVKTIPLTLMMAVLPIVFGFLVALGNIIVR IFRIKGLVACSRFYVSFFRSTPAILHIMLIYLGIPPVADQVSSFFHLGWSANEIPVSM FVIMALSLTAGAYLTEIIRSGILAMDTGQVEAAYSIGLTYSQTFRRVILPQALKVSIP NFTNLGIGFLHTTSIAAIVAVPEITGTATIVASDNYAFLEAFIGAAIIYWVLTLILES ANGVLERKAARFQGGTL*" /label="tcyM CDS" gene complement(2656237..2656944) /gene="tcyM" /locus_tag="BSU_29350" /old_locus_tag="BSU29350" /label="tcyM gene" CDS complement(2656974..2657693) /gene="tcyL" /locus_tag="BSU_29360" /old_locus_tag="BSU29360" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 15262924, 15849754, 16850406, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 15262924, 15849754, 16850406, 23944997; Product type t : transporter" /codon_start=1 /transl_table=11 /product="sulfur-containing amino acid ABC transporter (permease)" /protein_id="NP_390814.1" /db_xref="EnsemblGenomes-Gn:BSU29360" /db_xref="EnsemblGenomes-Tr:CAB14896" /db_xref="GOA:O34315" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR010065" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG13886" /db_xref="UniProtKB/Swiss-Prot:O34315" /translation="MEKAFDMNMIGDFVPTLTAYLPVTLYILTLSLLFGFVLGLFLAL PRIYNIPIVNQLAKVYISFFRGTPIMVQLFIVFYGIPALTGLIGIDTSKMDPFYAAVA TYALSNAAAAAEIIRAGVGSVDKGQTEAAYSIGLSGSQAFRRIVLPQALVQAFPNMGN MVISSLKDTSLAFSIGVMDMSGRGQTLITSSNHSLEVYIALSIVYYAVAVLFEWFFRV AEKRIKKNQTRIVTVFDMNIH*" /label="tcyL CDS" gene complement(2656974..2657693) /gene="tcyL" /locus_tag="BSU_29360" /old_locus_tag="BSU29360" /label="tcyL gene" promotor_-35 2657519..2657526 /Source="Nicolas_upshift_promotors" /id="U2270" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig="0.632367632367632" /xcortree=1226 /SigmaFactorBS="caccatgataggcgttcccctgaaaaacgagatatacaCTTT TGCCaattgatttacaatTGGAATATTATAGATGCGGGgcagtgccagaaagagtcct a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2657541..2657560 /Source="Nicolas_upshift_promotors" /id="U2270" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig="0.632367632367632" /xcortree=1226 /SigmaFactorBS="caccatgataggcgttcccctgaaaaacgagatatacaCTTT TGCCaattgatttacaatTGGAATATTATAGATGCGGGgcagtgccagaaagagtcct a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2657541 /Source="Nicolas_upshifts" /id="U2270" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig="0.632367632367632" /xcortree=1226 /SigmaFactorBS="caccatgataggcgttcccctgaaaaacgagatatacaCTTT TGCCaattgatttacaatTGGAATATTATAGATGCGGGgcagtgccagaaagagtcct a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2657715..2658527) /gene="tcyK" /locus_tag="BSU_29370" /old_locus_tag="BSU29370" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 15262924, 22720735, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 15262924, 22720735, 23944997; Product type t : transporter" /codon_start=1 /transl_table=11 /product="sulfur-containing amino acid ABC transporter binding lipoprotein" /protein_id="NP_390815.1" /db_xref="EnsemblGenomes-Gn:BSU29370" /db_xref="EnsemblGenomes-Tr:CAB14897" /db_xref="GOA:O34852" /db_xref="InterPro:IPR001638" /db_xref="PDB:2O1M" /db_xref="SubtiList:BG13885" /db_xref="UniProtKB/Swiss-Prot:O34852" /translation="MKTKTAFMAILFSLITVLSACGAGSQTTGAGQKKVQTITVGTGT QFPNICFIDEKGDLTGYDVELIKELDKRLPHYKFTFKTMEFSNLLVSLGQHKVDIVAH QMEKSKEREKKFLFNKVAYNHFPLKITVLQNNDTIRGIEDLKGKRVITSATSNGALVL KKWNEDNGRPFEIAYEGQGANETANQLKSGRADATISTPFAVDFQNKTSTIKEKTVGN VLSNAKVYFMFNKNEQTLSDDIDKALQEIIDDGTLKRLSLKWLGDDYSKEQY*" /label="tcyK CDS" gene complement(2657715..2658527) /gene="tcyK" /locus_tag="BSU_29370" /old_locus_tag="BSU29370" /label="tcyK gene" CDS complement(2658541..2659350) /gene="tcyJ" /locus_tag="BSU_29380" /old_locus_tag="BSU29380" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10939241, 11423008, 15262924, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11423008, 15262924, 23944997; Product type t: transporter" /codon_start=1 /transl_table=11 /product="sulfur containing amino acid ABC transporter binding lipoprotein" /protein_id="NP_390816.1" /db_xref="EnsemblGenomes-Gn:BSU29380" /db_xref="EnsemblGenomes-Tr:CAB14898" /db_xref="GOA:O34406" /db_xref="InterPro:IPR001638" /db_xref="SubtiList:BG13884" /db_xref="UniProtKB/Swiss-Prot:O34406" /translation="MNKRKGLVLLLSVFALLGGGCSQTNNKTDRQAQTVIVGTGTDFP NIAFLNEKGELTGYDIEVMKAIDKELPQYTFEFKTMDFSNLLTSLGNKKIDVIAHNMA KNKEREKRFLYHKVPYNYSPMYITVKEDNHKIHTLKDLHGKTVIVGATSNAADYITKY NKTHGSPIHLKYAGQGSNDTANQIETGRADATIATPFAVDFQNKTHAFRQKTVGDVLL DTEVYFMFNKGSQTLADDTDQAIKKLEKNGTLKKLSRKWLGADYSKSSFEK*" /label="tcyJ CDS" gene complement(2658541..2659350) /gene="tcyJ" /locus_tag="BSU_29380" /old_locus_tag="BSU29380" /label="tcyJ gene" CDS complement(2659364..2659900) /gene="snaA" /locus_tag="BSU_29390" /old_locus_tag="BSU29390" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11390694, 11423008, 16109943, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11390694, 11423008, 16109943, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetyltransferase acting on sulfur compounds" /protein_id="NP_390817.1" /db_xref="EnsemblGenomes-Gn:BSU29390" /db_xref="EnsemblGenomes-Tr:CAB14899" /db_xref="GOA:O34350" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13883" /db_xref="UniProtKB/Swiss-Prot:O34350" /translation="MSDDIFRLATVEDASELLKLVNSAFQPIRQLDIDWPSTRADIQM VSENIEHHSAIVLERDGKLISTITIRFPWESETPPSKYPFVWWFATLPEYKGQGAGSK LLTYVEEKVLRDMLKAPALTLGTSARKHPWLADMYRRRGYEVYFEQEKDGDIGVMMHK VLIPERFNPTLLGAPSWA*" /label="snaA CDS" gene complement(2659364..2659900) /gene="snaA" /locus_tag="BSU_29390" /old_locus_tag="BSU29390" /label="snaA gene" promotor_-35 2659937..2659944 /Source="Nicolas_upshift_promotors" /id="U2271" /multdbtbs="SigA,SigA" /comp="M17" /sig="SigA" /pcomp="0.357642357642358" /psig=1 /xcortree=1744 /SigmaFactorBS="ttttgtcactcctcttcacaaaatatataattcctaTTTGTT TActaagcttttattGTTTATACTATAAAGCATACtctgatctttgactaatcaaaaa a" /listShort="S1115, ytlI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2659955..2659974) /Source="Nicolas_upshift_promotors" /id="U2272" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.673326673326673" /psig=1 /xcortree=1739 /SigmaFactorBS="tcattaaaattactgaagtgaaggtttactttttttGATTAG TCaaagatcagagtaTGCTTTATAGTATAAACAATaaaagcttagtaaacaaatagga a" /listShort="ytmI, tcyJ, tcyK, tcyL, tcyM, tcyN, ytmO, ytnI, ytnJ, rbfK, ytnL, ytnM, ytoI" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 2659958..2659977 /Source="Nicolas_upshift_promotors" /id="U2271" /multdbtbs="SigA,SigA" /comp="M17" /sig="SigA" /pcomp="0.357642357642358" /psig=1 /xcortree=1744 /SigmaFactorBS="ttttgtcactcctcttcacaaaatatataattcctaTTTGTT TActaagcttttattGTTTATACTATAAAGCATACtctgatctttgactaatcaaaaa a" /listShort="S1115, ytlI" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2659961..2660052 /Source="Nicolas_S_feature" /locus_tag="new_3008846_3008937" /HighExp="dia5, MG 5, UNK1, MG t5, MG 10, B60, dia0, nit, Diami, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1115" upshifts 2659961 /Source="Nicolas_upshifts" /id="U2271" /multdbtbs="SigA,SigA" /comp="M17" /sig="SigA" /pcomp="0.357642357642358" /psig=1 /xcortree=1744 /SigmaFactorBS="ttttgtcactcctcttcacaaaatatataattcctaTTTGTT TActaagcttttattGTTTATACTATAAAGCATACtctgatctttgactaatcaaaaa a" /listShort="S1115, ytlI" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2659971) /Source="Nicolas_upshifts" /id="U2272" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.673326673326673" /psig=1 /xcortree=1739 /SigmaFactorBS="tcattaaaattactgaagtgaaggtttactttttttGATTAG TCaaagatcagagtaTGCTTTATAGTATAAACAATaaaagcttagtaaacaaatagga a" /listShort="ytmI, tcyJ, tcyK, tcyL, tcyM, tcyN, ytmO, ytnI, ytnJ, rbfK, ytnL, ytnM, ytoI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2659988..2659995) /Source="Nicolas_upshift_promotors" /id="U2272" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.673326673326673" /psig=1 /xcortree=1739 /SigmaFactorBS="tcattaaaattactgaagtgaaggtttactttttttGATTAG TCaaagatcagagtaTGCTTTATAGTATAAACAATaaaagcttagtaaacaaatagga a" /listShort="ytmI, tcyJ, tcyK, tcyL, tcyM, tcyN, ytmO, ytnI, ytnJ, rbfK, ytnL, ytnM, ytoI" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2660053..2660979 /gene="ascR" /locus_tag="BSU_29400" /old_locus_tag="BSU29400" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11390694, 11423008, 15272571, 16109943, 16513748, 22212096, 23944997" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11390694, 11423008, 15272571, 16109943, 16513748, 22212096, 23944997; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of operon snaA-ytnM degrading cysteine-containing compounds (AscR-N-acetylcysteine)" /protein_id="NP_390818.1" /db_xref="EnsemblGenomes-Gn:BSU29400" /db_xref="EnsemblGenomes-Tr:CAB14900" /db_xref="GOA:O35038" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13877" /db_xref="UniProtKB/Swiss-Prot:O35038" /translation="MELRSIKTFHTIVKFGSFYKAAEILNYSQPTISMRMKQLEQDLG VLLFERGKSLQLTKAGKLFYERTGDLLMQYEALKHNLSDLKEEEAGIINIGVSEPTAS LIFPEILKDFLMDYPKITVNIKVDDANTCSQKLLDGTIDFAVCGEPELILENYYHPFF YDTLNVIVSDQHPLAEKKAVHLSDLAEERFIFTPANCPIRLQIEQHLHRELGNRYKKM ELTSSMSHEYYVRENIGISIFTSTAHSKPFNGTKVIPILNLDITPPIGLLTNQKEVHF DRATKDLIARITKRFQQRSKELEGTSDKTITG*" /label="ascR CDS" gene 2660053..2660979 /gene="ascR" /locus_tag="BSU_29400" /old_locus_tag="BSU29400" /label="ascR gene" S_feature complement(2660455..2660984) /Source="Nicolas_S_feature" /locus_tag="new_3009340_3009869_c" /HighExp="Etha, dia15, dia5, H2O2, M9-stat, M40t90, Sw, Gly, M0t90, Cold" /AntisenseName="ytlI" /AntisenseCor="-7.8012588423369304E-3" /AntisenseRegPval=0 /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1116" downshifts complement(2661029) /Source="Nicolas_upshifts" /id="D1503" /incds=0 /nref=142 /ntot=251 /MaxReadThrough="4.32965" /MaxDrop="5.01142" /score="39.1547987" /energy="-16.5" /TU="U2273" /idTUdmin="U2274" /TUdmin=20 /isTUend="TRUE" /label="downshifts" CDS complement(2661030..2661713) /gene="ytkL" /locus_tag="BSU_29410" /old_locus_tag="BSU29410" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent hydrolase" /protein_id="NP_390819.2" /db_xref="EnsemblGenomes-Gn:BSU29410" /db_xref="EnsemblGenomes-Tr:CAB14901" /db_xref="GOA:Q795U4" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR022877" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG13871" /db_xref="UniProtKB/Swiss-Prot:Q795U4" /translation="MKVTYHGHSVITVETKDHHIIFDPFLTGNSLTDIKPEDVKADVI LLTHGHNDHVGDTEQIAKQNNALVIAPNELAVYLGWKGLNVHPMHIGGSRQFDFGKVK LTQAFHGSAITDEENKTITYTGMPAGILLTVEDKTIFHAGDTALFSDMKLIGELNHID LAFLPIGDNFTMGPEDAKLAAEWLRAKQVVPVHYNTFPVIEQDPEAFADSLPGGVGKV MSVGETIEL*" /label="ytkL CDS" gene complement(2661030..2661713) /gene="ytkL" /locus_tag="BSU_29410" /old_locus_tag="BSU29410" /label="ytkL gene" S_feature complement(2661714..2661775) /Source="Nicolas_S_feature" /locus_tag="new_3010599_3010660_c" /HighExp="dia15, Etha, dia5, Diami, H2O2, M0t90, M40t90, Salt, LBGtran, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1117" CDS complement(2661776..2662543) /gene="ytkK" /locus_tag="BSU_29420" /old_locus_tag="BSU29420" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 3-oxoacyl-acyl-carrier protein reductase" /protein_id="NP_390820.1" /db_xref="EnsemblGenomes-Gn:BSU29420" /db_xref="EnsemblGenomes-Tr:CAB14902" /db_xref="GOA:O34308" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13870" /db_xref="UniProtKB/Swiss-Prot:O34308" /translation="MRHALITAGSKGLGRKVTETLLAKGYSVTVNYRQDEEAVSRLKE ACPDCLDRLQFVKGDVTKKEDLLRIAEAALNRFGRIDFLINNAGPYIFERKKLADYTD DEWYGMLEGNLSAVFHLFKAVIPIMRKQQFGRIITYGFQGAAHAPGWLHRSAFGAAKV GLASLTKTIAIEEAEFGITANMVCPGDIVGDMKEASIEEARMRIGKEKTPIGRSGTGE DIARIIAFLCEENSDLVTGTVIEATGGLNVINKNQTT*" /label="ytkK CDS" gene complement(2661776..2662543) /gene="ytkK" /locus_tag="BSU_29420" /old_locus_tag="BSU29420" /label="ytkK gene" promotor_-10 complement(2662588..2662607) /Source="Nicolas_upshift_promotors" /id="U2273" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.772227772227772" /psig="0.999000999001" /xcortree=1987 /SigmaFactorBS="agctgtctgtacaggcagctttttttgtatgccaaagtgtaa aaaGTGatattgcaagcctttTATAGTAAAGTAGAAGAAGAaacactttattgaaagc g" /listShort="ytkK, S1117, ytkL, S1116" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2662610) /Source="Nicolas_upshifts" /id="U2273" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.772227772227772" /psig="0.999000999001" /xcortree=1987 /SigmaFactorBS="agctgtctgtacaggcagctttttttgtatgccaaagtgtaa aaaGTGatattgcaagcctttTATAGTAAAGTAGAAGAAGAaacactttattgaaagc g" /listShort="ytkK, S1117, ytkL, S1116" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2662623..2662625) /Source="Nicolas_upshift_promotors" /id="U2273" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.772227772227772" /psig="0.999000999001" /xcortree=1987 /SigmaFactorBS="agctgtctgtacaggcagctttttttgtatgccaaagtgtaa aaaGTGatattgcaagcctttTATAGTAAAGTAGAAGAAGAaacactttattgaaagc g" /listShort="ytkK, S1117, ytkL, S1116" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2662670..2662906) /gene="ytzD" /locus_tag="BSU_29430" /old_locus_tag="BSU29430" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11423008" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390821.3" /db_xref="EnsemblGenomes-Gn:BSU29430" /db_xref="EnsemblGenomes-Tr:CAB14903" /db_xref="SubtiList:BG13938" /db_xref="UniProtKB/Swiss-Prot:O34503" /translation="MKKRKLAWQQEFVKISFIKSRHYSQPTSIMMGGRMMKKEPERYI YDEQESQETTRLISEAYQSGYVDMPDQESSSPAE*" /label="ytzD CDS" gene complement(2662670..2662906) /gene="ytzD" /locus_tag="BSU_29430" /old_locus_tag="BSU29430" /label="ytzD gene" downshifts 2662755 /Source="Nicolas_upshifts" /id="D1504" /incds=0 /nref=1 /ntot=12 /MaxReadThrough="0.55049" /MaxDrop="4.17437" /score="-5.88070891" /energy="-8.9" /TU="NA" /idTUdmin="U2271" /TUdmin=1782 /isTUend="FALSE" /label="downshifts" downshifts complement(2662775) /Source="Nicolas_upshifts" /id="D1505" /incds=0 /nref=199 /ntot=288 /MaxReadThrough="5.44889" /MaxDrop="6.29233" /score="21.2322542" /energy="-8.5" /TU="U2274" /idTUdmin="U2274" /TUdmin="-1726" /isTUend="FALSE" /label="downshifts" CDS complement(2662866..2664251) /gene="argH" /locus_tag="BSU_29440" /old_locus_tag="BSU29440" /EC_number="4.3.2.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2989674, 9890879, 11423008" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2989674, 9890879, 11423008; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="argininosuccinate lyase" /protein_id="NP_390822.1" /db_xref="EnsemblGenomes-Gn:BSU29440" /db_xref="EnsemblGenomes-Tr:CAB14904" /db_xref="GOA:O34858" /db_xref="InterPro:IPR000362" /db_xref="InterPro:IPR008948" /db_xref="InterPro:IPR009049" /db_xref="InterPro:IPR020557" /db_xref="InterPro:IPR022761" /db_xref="InterPro:IPR024083" /db_xref="InterPro:IPR029419" /db_xref="SubtiList:BG12571" /db_xref="UniProtKB/Swiss-Prot:O34858" /translation="MKKLWGGRFQKTPEKWVDEFGASISFDQNLVAEDITGSLAHAAM LKKCGILTAEEELKIREGLNTLLQKAEEGALEFSVDYEDIHLNIEKMLIDEIGPLGGK LHTGRSRNDQVATDMHLYLKNHVGHIIELIEAFQSALIEKAEANVETILPGYTHLQRA QPISFAHHLLAYFWMLERDKERFQDSMKRINKSPLGCGALAGTTFPIDRDYSAELLGF DAIYENSLDGVSDRDFILEFLSNSSMLMMHLSRFSEEIILWCSQEFKFIELDDTYATG SSMMPQKKNPDMAELIRGKTGRVYGDMMGLFTIMKGLPLAYNKDLQEDKEGMFDTVKT VEGSLQIFTGMIQTMTVNKDVMKQATKQDFSNATELADYLAKKGMPFREAHEVVGKLV YTCIERGIYLSDMPFGEFQQASTLFEEDIYTVLDPYYAVEKRMSAGGTGFKQVEQALE KAKACVAAGVC*" /label="argH CDS" gene complement(2662866..2664251) /gene="argH" /locus_tag="BSU_29440" /old_locus_tag="BSU29440" /label="argH gene" CDS complement(2664248..2665459) /gene="argG" /locus_tag="BSU_29450" /old_locus_tag="BSU29450" /EC_number="6.3.4.5" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2989674, 11423008, 12963366, 17611193" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2989674, 11423008, 12963366, 17611193; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="argininosuccinate synthase" /protein_id="NP_390823.1" /db_xref="EnsemblGenomes-Gn:BSU29450" /db_xref="EnsemblGenomes-Tr:CAB14905" /db_xref="GOA:O34347" /db_xref="InterPro:IPR001518" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR018223" /db_xref="InterPro:IPR023434" /db_xref="InterPro:IPR024074" /db_xref="SubtiList:BG12570" /db_xref="UniProtKB/Swiss-Prot:O34347" /translation="MSEQKKVVLAYSGGLDTSVAIKWLQEQGYNVIACCLDVGEGKDL AFVQQKALEVGATNSYVIDAKEEFAQDYALISLQAHTMYEGKYPLVSALSRPLIAKKL VEIAEKEDAQAIAHGCTGKGNDQVRFEVSIKSLNPDLEVIAPVREWQWSREEEIEYAA SRGIPIPINLDSPYSIDQNLWGRANECGILEDPWAAPPEGAYDLTAPLEKTPDTPEVI EIAFEQGVPVSIDGVSYSLSELILKLNEMAGAHGVGRIDHVENRLVGIKSREVYECPG AMTLIKAHKELEDLTLVKEVAHFKPIIEQKMSEIIYNGLWFSPLKDALHAFLKETQKH VTGIVRVKLFKGHAIVEGRKSEYSLYDEKLATYTKDDAFDHHAAIGFIELWGLPTKVN SIVKKKEQIKA*" /label="argG CDS" gene complement(2664248..2665459) /gene="argG" /locus_tag="BSU_29450" /old_locus_tag="BSU29450" /label="argG gene" S_feature complement(2665460..2665537) /Source="Nicolas_S_feature" /locus_tag="new_3014345_3014422_c" /HighExp="S1, MG 15, T3.0H, T3.30H, T4.0H, T5.0H, BMM, T2.30H, T-0.40H, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1118" promotor_-10 complement(2665530..2665549) /Source="Nicolas_upshift_promotors" /id="U2274" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=2914 /SigmaFactorBS="ttaggtgaagttttttttataaaagGCTTGAAAaaacgaaac gtactTGTTAAAGTGTATACATACAaaatgtatttttattaaatataatttattttta t" /listShort="S1118, argG, argH, ytzD, ytkK, S1117, ytkL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2665536) /Source="Nicolas_upshifts" /id="U2274" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=2914 /SigmaFactorBS="ttaggtgaagttttttttataaaagGCTTGAAAaaacgaaac gtactTGTTAAAGTGTATACATACAaaatgtatttttattaaatataatttattttta t" /listShort="S1118, argG, argH, ytzD, ytkK, S1117, ytkL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2665564..2665571) /Source="Nicolas_upshift_promotors" /id="U2274" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=2914 /SigmaFactorBS="ttaggtgaagttttttttataaaagGCTTGAAAaaacgaaac gtactTGTTAAAGTGTATACATACAaaatgtatttttattaaatataatttattttta t" /listShort="S1118, argG, argH, ytzD, ytkK, S1117, ytkL" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2665629..2666141) /gene="moaB" /locus_tag="BSU_29460" /old_locus_tag="BSU29460" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15269205, 20054111, 23680484; Product type f: factor" /codon_start=1 /transl_table=11 /product="molybdopterin GTP-binding precursor Z biosynthesis component" /protein_id="NP_390824.1" /db_xref="EnsemblGenomes-Gn:BSU29460" /db_xref="EnsemblGenomes-Tr:CAB14924" /db_xref="GOA:O34457" /db_xref="InterPro:IPR001453" /db_xref="InterPro:IPR008284" /db_xref="InterPro:IPR012245" /db_xref="InterPro:IPR036425" /db_xref="SubtiList:BG12618" /db_xref="UniProtKB/Swiss-Prot:O34457" /translation="MSVQEHKQEAPDIVRCKVITVSDTRTDETDKSGKLMISFLEEAG HHIAAYEIVKDEKDALQRSVLAGCMDEQTDAVLLNGGTGIADRDVTIEAITPLFSKEL PGFGEIFRMLSYTEDIGSAAIMSRATAGVIQHTAVFSTPGSSGAVKLAMNKLIIPELA HVVREIRKDK*" /label="moaB CDS" gene complement(2665629..2666141) /gene="moaB" /locus_tag="BSU_29460" /old_locus_tag="BSU29460" /label="moaB gene" downshifts complement(2665647) /Source="Nicolas_upshifts" /id="D1506" /incds=0 /nref=122 /ntot=221 /MaxReadThrough="1.48097" /MaxDrop="4.78155" /score="25.7910606" /energy="-10.8" /TU="NA" /idTUdmin="U2275" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2666167..2666186) /Source="Nicolas_upshift_promotors" /id="U2275" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.878121878121878" /psig=1 /xcortree=109 /SigmaFactorBS="agcaaaataaatcgcatgaaagcacattCTCTTGAAtgtgct tttttgtTGATGCATGATAGTGACAGAcagaaaacataaaagaggtgggccaatgagc g" /listShort="moaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2666175) /Source="Nicolas_upshifts" /id="U2275" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.878121878121878" /psig=1 /xcortree=109 /SigmaFactorBS="agcaaaataaatcgcatgaaagcacattCTCTTGAAtgtgct tttttgtTGATGCATGATAGTGACAGAcagaaaacataaaagaggtgggccaatgagc g" /listShort="moaB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2666200..2666207) /Source="Nicolas_upshift_promotors" /id="U2275" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.878121878121878" /psig=1 /xcortree=109 /SigmaFactorBS="agcaaaataaatcgcatgaaagcacattCTCTTGAAtgtgct tttttgtTGATGCATGATAGTGACAGAcagaaaacataaaagaggtgggccaatgagc g" /listShort="moaB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2666226..2667413) /gene="ackA" /locus_tag="BSU_29470" /old_locus_tag="BSU29470" /EC_number="2.7.2.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8226682, 9811655, 11244084, 16995897, 19019159, 26098117" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8226682, 9811655, 11244084, 16995897, 19019159, 26098117; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="acetate kinase" /protein_id="NP_390825.1" /db_xref="EnsemblGenomes-Gn:BSU29470" /db_xref="EnsemblGenomes-Tr:CAB14925" /db_xref="GOA:P37877" /db_xref="InterPro:IPR000890" /db_xref="InterPro:IPR004372" /db_xref="InterPro:IPR023865" /db_xref="SubtiList:BG10813" /db_xref="UniProtKB/Swiss-Prot:P37877" /translation="MSKIIAINAGSSSLKFQLFEMPSETVLTKGLVERIGIADSVFTI SVNGEKNTEVTDIPDHAVAVKMLLNKLTEFGIIKDLNEIDGIGHRVVHGGEKFSDSVL LTDETIKEIEDISELAPLHNPANIVGIKAFKEVLPNVPAVAVFDTAFHQTMPEQSYLY SLPYEYYEKFGIRKYGFHGTSHKYVTERAAELLGRPLKDLRLISCHLGNGASIAAVEG GKSIDTSMGFTPLAGVAMGTRSGNIDPALIPYIMEKTGQTADEVLNTLNKKSGLLGIS GFSSDLRDIVEATKEGNERAETALEVFASRIHKYIGSYAARMSGVDAIIFTAGIGENS VEVRERVLRGLEFMGVYWDPALNNVRGEEAFISYPHSPVKVMIIPTDEEVMIARDVVR LAK*" /label="ackA CDS" gene complement(2666226..2667413) /gene="ackA" /locus_tag="BSU_29470" /old_locus_tag="BSU29470" /label="ackA gene" downshifts complement(2666241) /Source="Nicolas_upshifts" /id="D1507" /incds=0 /nref=13 /ntot=117 /MaxReadThrough="5.03131" /MaxDrop="3.1641" /score="19.2403206" /energy="-9.9" /TU="U2276" /idTUdmin="U2277" /TUdmin=242 /isTUend="FALSE" /label="downshifts" S_feature complement(2667414..2667518) /Source="Nicolas_S_feature" /locus_tag="new_3016299_3016403_c" /HighExp="dia0, Lbexp, LBGtran, Oxctl, LPh, M0t45, HPh, Paraq, H2O2, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF" /TUshortPSig="0.999, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1119" promotor_-10 complement(2667503..2667522) /Source="Nicolas_upshift_promotors" /id="U2276" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.918081918081918" /psig="0.999000999001" /xcortree=2694 /SigmaFactorBS="gacttcttattgtaagcgttatcaatacgcaagttgACTTGa aaagccgacatgacAATGTTTAAATGGAAAAGTCagatatttttcggagaagatgttg a" /listShort="S1119, ackA, moaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2667518) /Source="Nicolas_upshifts" /id="U2276" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.918081918081918" /psig="0.999000999001" /xcortree=2694 /SigmaFactorBS="gacttcttattgtaagcgttatcaatacgcaagttgACTTGa aaagccgacatgacAATGTTTAAATGGAAAAGTCagatatttttcggagaagatgttg a" /listShort="S1119, ackA, moaB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2667520..2667649) /Source="Nicolas_S_feature" /locus_tag="new_3016405_3016534_c" /HighExp="S5, S6, S7, S8, S4, dia5, BT, H2O2, dia15, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1120" promotor_-35 complement(2667538..2667542) /Source="Nicolas_upshift_promotors" /id="U2276" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.918081918081918" /psig="0.999000999001" /xcortree=2694 /SigmaFactorBS="gacttcttattgtaagcgttatcaatacgcaagttgACTTGa aaagccgacatgacAATGTTTAAATGGAAAAGTCagatatttttcggagaagatgttg a" /listShort="S1119, ackA, moaB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2667586..2667789) /locus_tag="BSU_29479" /old_locus_tag="BSU29479" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513997.1" /translation="MMNGLKKKSKCFKSSLDSRMRSMPKLLLFMLLKTGLDELNPALK HKIQREKPQIVSVHQYKTYSECV*" /label="hypothetical protein CDS" gene complement(2667586..2667789) /locus_tag="BSU_29479" /old_locus_tag="BSU29479" /label="gene" promotor_-10 complement(2667647..2667658) /Source="Nicolas_upshift_promotors" /id="U2277" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=888 /SigmaFactorBS="tttatttatgcttttgaagaccggacttgaCGAATTGaatcc agctttgaaACACAAAATACAgagggaaaaaccgcaaattgtaagcgttcatcaatac a" /listShort="S1120, S1119, ackA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2667649) /Source="Nicolas_upshifts" /id="U2277" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=888 /SigmaFactorBS="tttatttatgcttttgaagaccggacttgaCGAATTGaatcc agctttgaaACACAAAATACAgagggaaaaaccgcaaattgtaagcgttcatcaatac a" /listShort="S1120, S1119, ackA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2667673..2667679) /Source="Nicolas_upshift_promotors" /id="U2277" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=888 /SigmaFactorBS="tttatttatgcttttgaagaccggacttgaCGAATTGaatcc agctttgaaACACAAAATACAgagggaaaaaccgcaaattgtaagcgttcatcaatac a" /listShort="S1120, S1119, ackA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2667761..2668750) /gene="ytxK" /locus_tag="BSU_29480" /old_locus_tag="BSU29480" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative nucleic acid methyltransferase" /protein_id="NP_390826.1" /db_xref="EnsemblGenomes-Gn:BSU29480" /db_xref="EnsemblGenomes-Tr:CAB14926" /db_xref="GOA:P37876" /db_xref="InterPro:IPR003356" /db_xref="InterPro:IPR016843" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG10812" /db_xref="UniProtKB/Swiss-Prot:P37876" /translation="MQKDHVGAVYELLNEAAIMIKNELQISYIEALAEAGEMYFLEKT DQLKLPADQKTKQLQALLEKAEFGTYEHEWVRKAFQLAVLKGMKDISHPNRQMTPDTI GLFISYLVNKFMADKKELTILDPALGTGNLLFTVLNQLSEKTANSFGIEIDDVLLKIA YAQANLLKKELELFHQDSLEPLFIDPVDTVICDLPVGYYPNDEGAEAFELKADEGHSF AHHLFIEQSVKHTKPGGYLFFMIPNHLFESSQSGKLKQFFKDKVHINALLQLPKSIFK DEAHAKSILVLQKQGENTKAPGQILLANLPSFSNQKAMLDMMAQFDEWFKKEK*" /label="ytxK CDS" gene complement(2667761..2668750) /gene="ytxK" /locus_tag="BSU_29480" /old_locus_tag="BSU29480" /label="ytxK gene" downshifts complement(2667779) /Source="Nicolas_upshifts" /id="D1508" /incds=0 /nref=158 /ntot=243 /MaxReadThrough="3.51469" /MaxDrop="5.25938" /score="-4.33730173" /energy="-13.3" /TU="NA" /idTUdmin="U2279" /TUdmin="-20" /isTUend="TRUE" /label="downshifts" CDS complement(2668811..2669314) /gene="tpx" /locus_tag="BSU_29490" /old_locus_tag="BSU29490" /EC_number="1.11.1.15" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12486061, 18588855, 18588855, 23899494, 25355936, 25852656" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12486061, 18588855, 18588855, 23899494, 25355936, 25852656; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="thiol peroxidase (lipid hydroperoxide reductase)" /protein_id="NP_390827.1" /db_xref="EnsemblGenomes-Gn:BSU29490" /db_xref="EnsemblGenomes-Tr:CAB14927" /db_xref="GOA:P80864" /db_xref="InterPro:IPR002065" /db_xref="InterPro:IPR013740" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR018219" /db_xref="InterPro:IPR036249" /db_xref="PDB:2JSY" /db_xref="PDB:2JSZ" /db_xref="SubtiList:BG13855" /db_xref="UniProtKB/Swiss-Prot:P80864" /translation="MAEITFKGGPVTLVGQEVKVGDQAPDFTVLTNSLEEKSLADMKG KVTIISVIPSIDTGVCDAQTRRFNEEAAKLGDVNVYTISADLPFAQARWCGANGIDKV ETLSDHRDMSFGEAFGVYIKELRLLARSVFVLDENGKVVYAEYVSEATNHPNYEKPIE AAKALVK*" /label="tpx CDS" gene complement(2668811..2669314) /gene="tpx" /locus_tag="BSU_29490" /old_locus_tag="BSU29490" /label="tpx gene" downshifts complement(2668817) /Source="Nicolas_upshifts" /id="D1509" /incds=0 /nref=53 /ntot=241 /MaxReadThrough="6.94509" /MaxDrop="4.3179" /score="9.29337297" /energy="-10.1" /TU="U2279" /idTUdmin="U2280" /TUdmin=548 /isTUend="FALSE" /label="downshifts" promotor_no_box 2669031..2669131 /Source="Nicolas_upshift_promotors" /id="U2278" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.924075924075924" /psig="0.001998001998002" /xcortree=44 /SigmaFactorBS="ccgcaccagcgcgcttgcgcgaatggaaggtctgcactgatt gtgtagacgttgacatctccaagctttgcagcttcttcgttaaaacggcgtgtttgtg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 2669091 /Source="Nicolas_upshifts" /id="U2278" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.924075924075924" /psig="0.001998001998002" /xcortree=44 /SigmaFactorBS="ccgcaccagcgcgcttgcgcgaatggaaggtctgcactgatt gtgtagacgttgacatctccaagctttgcagcttcttcgttaaaacggcgtgtttgtg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2669310 /Source="Nicolas_upshifts" /id="D1510" /incds=0 /nref=86 /ntot=184 /MaxReadThrough="2.23568" /MaxDrop="5.49495" /score="20.1242958" /energy="-12.7" /TU="NA" /idTUdmin="U2278" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2669337..2669356) /Source="Nicolas_upshift_promotors" /id="U2279" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=2364 /SigmaFactorBS="actgcgctggccgcagttaacttttttttggcataaACTTTG CAgtttgcaggaaacTTTACTATGATAGAGACATAcatacaaaagggaggaattataa t" /listShort="tpx, ytxK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2669353) /Source="Nicolas_upshifts" /id="U2279" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=2364 /SigmaFactorBS="actgcgctggccgcagttaacttttttttggcataaACTTTG CAgtttgcaggaaacTTTACTATGATAGAGACATAcatacaaaagggaggaattataa t" /listShort="tpx, ytxK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2669370..2669377) /Source="Nicolas_upshift_promotors" /id="U2279" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.867132867132867" /psig=1 /xcortree=2364 /SigmaFactorBS="actgcgctggccgcagttaacttttttttggcataaACTTTG CAgtttgcaggaaacTTTACTATGATAGAGACATAcatacaaaagggaggaattataa t" /listShort="tpx, ytxK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2669424..2669879) /gene="gerW" /locus_tag="BSU_29500" /old_locus_tag="BSU29500" /experiment="publication(s) with functional evidences, PMID:23921501, 25790435, 27881417" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23921501, 25790435, 27881417; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="germination-associated protein" /protein_id="NP_390828.1" /db_xref="EnsemblGenomes-Gn:BSU29500" /db_xref="EnsemblGenomes-Tr:CAB14928" /db_xref="GOA:O34806" /db_xref="InterPro:IPR014229" /db_xref="SubtiList:BG13849" /db_xref="UniProtKB/Swiss-Prot:O34806" /translation="MADHPIQGLMKTAMENLKEMIDVNTIIGDPVETPDGSVILTVSK VGFGFAAGGSEFGGKPAEKKSEDDETREQKLPFGGGSGGGVSITPIAFLIVGSTGIRM LHLDENTHLIEKILDAAPQTLERIQQMFKKNNKNQSQGQNQNQMNNMNY*" /label="gerW CDS" gene complement(2669424..2669879) /gene="gerW" /locus_tag="BSU_29500" /old_locus_tag="BSU29500" /label="gerW gene" downshifts complement(2669452) /Source="Nicolas_upshifts" /id="D1511" /incds=0 /nref=38 /ntot=91 /MaxReadThrough="3.69502" /MaxDrop="5.65648" /score="26.1939476" /energy="-12.7" /TU="U2280" /idTUdmin="U2280" /TUdmin="-87" /isTUend="FALSE" /label="downshifts" CDS complement(2669893..2670573) /gene="ytfI" /locus_tag="BSU_29510" /old_locus_tag="BSU29510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="conserved sporulation-related protein" /protein_id="NP_390829.1" /db_xref="EnsemblGenomes-Gn:BSU29510" /db_xref="EnsemblGenomes-Tr:CAB14929" /db_xref="InterPro:IPR021338" /db_xref="SubtiList:BG13848" /db_xref="UniProtKB/Swiss-Prot:O34917" /translation="MVYVLTAILILIGIVLLLRMKIHVALEYLHADDNDKLTLKITAL FGLIRIKKTIPAIKVNKEDGTVDIKQKTESKMKKSSGKKKITQNDVQQSINKIEMLLH QVTRLRKISASFLAHLHITKLEWVTVIGIQDAAVTGVLTGAVWGVKGGIAAMLYDHLD FVNKPVYEVIPSFQVPVSKTHFQCIFFFRFGHAMLAAFKFVKYGRELSVLKKNPSARM TSKNDSSV*" /label="ytfI CDS" gene complement(2669893..2670573) /gene="ytfI" /locus_tag="BSU_29510" /old_locus_tag="BSU29510" /label="ytfI gene" upshifts complement(2669985) /Source="Nicolas_upshifts" /id="U2280" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1136 /SigmaFactorBS="gtttccaagacccattttcagTGTATATtcttttttcgcttt GGACATGCTATGcttgcagctttcaaattcgtcaaatacggacgggagctatccgtat t" /listShort="ytfJ" /listLong="tpx, ytxK" /label="upshifts" promotor_-10 complement(2669992..2670003) /Source="Nicolas_upshift_promotors" /id="U2280" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1136 /SigmaFactorBS="gtttccaagacccattttcagTGTATATtcttttttcgcttt GGACATGCTATGcttgcagctttcaaattcgtcaaatacggacgggagctatccgtat t" /listShort="ytfJ" /listLong="tpx, ytxK" /label="promotor_-10" promotor_-35 complement(2670018..2670024) /Source="Nicolas_upshift_promotors" /id="U2280" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=1136 /SigmaFactorBS="gtttccaagacccattttcagTGTATATtcttttttcgcttt GGACATGCTATGcttgcagctttcaaattcgtcaaatacggacgggagctatccgtat t" /listShort="ytfJ" /listLong="tpx, ytxK" /label="promotor_-35" downshifts complement(2670311) /Source="Nicolas_upshifts" /id="D1512" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="4.64036" /MaxDrop="2.98792" /score="28.0381876" /energy="-11.8" /TU="U2281" /idTUdmin="U2281" /TUdmin="-308" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2670586..2670604) /Source="Nicolas_upshift_promotors" /id="U2281" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.516483516483517" /psig="0.516483516483517" /xcortree=1030 /SigmaFactorBS="ataccgcaaataaccgataacccggacttccgtccgGGTTTA tttttttaggaattGGCGATAATGCTCCTAGAGgaagtgaagaatatggtgtatgtac t" /listShort="ytfI" /listLong="ytfJ, tpx, ytxK" /label="promotor_-10" upshifts complement(2670600) /Source="Nicolas_upshifts" /id="U2281" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.516483516483517" /psig="0.516483516483517" /xcortree=1030 /SigmaFactorBS="ataccgcaaataaccgataacccggacttccgtccgGGTTTA tttttttaggaattGGCGATAATGCTCCTAGAGgaagtgaagaatatggtgtatgtac t" /listShort="ytfI" /listLong="ytfJ, tpx, ytxK" /label="upshifts" promotor_-35 complement(2670619..2670624) /Source="Nicolas_upshift_promotors" /id="U2281" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.516483516483517" /psig="0.516483516483517" /xcortree=1030 /SigmaFactorBS="ataccgcaaataaccgataacccggacttccgtccgGGTTTA tttttttaggaattGGCGATAATGCTCCTAGAGgaagtgaagaatatggtgtatgtac t" /listShort="ytfI" /listLong="ytfJ, tpx, ytxK" /label="promotor_-35" CDS complement(2670648..2671142) /gene="yteJ" /locus_tag="BSU_29520" /old_locus_tag="BSU29520" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 23155385; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_390830.1" /db_xref="EnsemblGenomes-Gn:BSU29520" /db_xref="EnsemblGenomes-Tr:CAB14930" /db_xref="GOA:O34424" /db_xref="InterPro:IPR010432" /db_xref="SubtiList:BG13840" /db_xref="UniProtKB/Swiss-Prot:O34424" /translation="MDATYEELERNDIKGPQEAELLTHAYAGFWVRFWAFLLDWLVIW GLNHLLVSPLFTVLDLPKTSGMFTFSAYSVTTLIVYLAYFALMTKYFRQTLGKMVFGL KVVSVKQDSKLTWSTVIFREVVGRYIDKIWILYIVVAFSPTKQGIHDYIADTTVVHEK LYRK*" /label="yteJ CDS" gene complement(2670648..2671142) /gene="yteJ" /locus_tag="BSU_29520" /old_locus_tag="BSU29520" /label="yteJ gene" downshifts complement(2670663) /Source="Nicolas_upshifts" /id="D1513" /incds=0 /nref=240 /ntot=258 /MaxReadThrough="1.43721" /MaxDrop="6.8315" /score="28.0381876" /energy="-11.8" /TU="NA" /idTUdmin="U2282" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2671155..2672162) /gene="sppA" /locus_tag="BSU_29530" /old_locus_tag="BSU29530" /function="16.1: Circulate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9987136, 10455123, 16484219, 22472423, 23155385, 24228759" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9987136, 10455123, 16484219, 22472423, 23155385, 24228759; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="signal peptide peptidase" /protein_id="NP_390831.1" /db_xref="EnsemblGenomes-Gn:BSU29530" /db_xref="EnsemblGenomes-Tr:CAB14931" /db_xref="GOA:O34525" /db_xref="InterPro:IPR002142" /db_xref="InterPro:IPR004635" /db_xref="InterPro:IPR029045" /db_xref="PDB:3RST" /db_xref="PDB:4KWB" /db_xref="SubtiList:BG13839" /db_xref="UniProtKB/Swiss-Prot:O34525" /translation="MNAKRWIALVIALGIFGVSIIVSISMSFFESVKGAQTDLTSLTD ESQEKTLENGSPSSKIAVLEVSGTIQDNGDSSSLLGADGYNHRTFLKNLERAKDDKTV KGIVLKVNSPGGGVYESAEIHKKLEEIKKETKKPIYVSMGSMAASGGYYISTAADKIF ATPETLTGSLGVIMESVNYSKLADKLGISFETIKSGAHKDIMSPSREMTKEEKNIMQS MVDNSYEGFVDVISKGRGMPKAEVKKIADGRVYDGRQAKKLNLVDELGFYDDTITAMK KDHKDLKNASVISYEESFGLGSLFSMGANKMFKSEIDFLNMREILSQSGSPRMMYLYA K*" /label="sppA CDS" gene complement(2671155..2672162) /gene="sppA" /locus_tag="BSU_29530" /old_locus_tag="BSU29530" /label="sppA gene" promotor_-10 complement(2672186..2672201) /Source="Nicolas_upshift_promotors" /id="U2282" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1672 /SigmaFactorBS="cgtttgccggcagcccgttaagccggagctttctcatgaagT GAAACATTTttcatattgaaTCGTATAATGAGAGAGtttaggaaaaaggaggagaaaa a" /listShort="sppA, yteJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2672203) /Source="Nicolas_upshifts" /id="U2282" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1672 /SigmaFactorBS="cgtttgccggcagcccgttaagccggagctttctcatgaagT GAAACATTTttcatattgaaTCGTATAATGAGAGAGtttaggaaaaaggaggagaaaa a" /listShort="sppA, yteJ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2672205..2672284) /Source="Nicolas_S_feature" /locus_tag="new_3021090_3021169_c" /HighExp="LBGexp, Oxctl, LBGtran, dia0, H2O2, dia15, G180, G150, Paraq, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1121" promotor_-35 complement(2672213..2672222) /Source="Nicolas_upshift_promotors" /id="U2282" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1672 /SigmaFactorBS="cgtttgccggcagcccgttaagccggagctttctcatgaagT GAAACATTTttcatattgaaTCGTATAATGAGAGAGtttaggaaaaaggaggagaaaa a" /listShort="sppA, yteJ" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 2672262..2672281 /Source="Nicolas_upshift_promotors" /id="U2283" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.783216783216783" /psig="0.982017982017982" /xcortree=384 /SigmaFactorBS="aaaatgtttcacttcatgagaaagctccggcttaacgggctg ccggcaaaCGTGGTACACTTATGGCCAAaggtattttatcacaaatactggatggcag a" /listShort="S1122, ppnKB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2672272 /Source="Nicolas_upshifts" /id="U2283" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.783216783216783" /psig="0.982017982017982" /xcortree=384 /SigmaFactorBS="aaaatgtttcacttcatgagaaagctccggcttaacgggctg ccggcaaaCGTGGTACACTTATGGCCAAaggtattttatcacaaatactggatggcag a" /listShort="S1122, ppnKB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2672277..2672296) /Source="Nicolas_upshift_promotors" /id="U2284" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2689 /SigmaFactorBS="ccatttcccctttgctgtcatatttaagTTTTTctgccatcc agtattTGTGATAAAATACCTTTGGCcataagtgtaccacgtttgccggcagcccgtt a" /listShort="S1121, sppA, yteJ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2672281..2672347 /Source="Nicolas_S_feature" /locus_tag="new_3021166_3021232" /HighExp="M0t90, Sw, M9-stat, BC, M40t90, T4.0H, T2.30H, S1, T3.30H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.982" /TUlongSig="NA" /TUlongPSig="NA" /label="S1122" upshifts complement(2672284) /Source="Nicolas_upshifts" /id="U2284" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2689 /SigmaFactorBS="ccatttcccctttgctgtcatatttaagTTTTTctgccatcc agtattTGTGATAAAATACCTTTGGCcataagtgtaccacgtttgccggcagcccgtt a" /listShort="S1121, sppA, yteJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2672312..2672316) /Source="Nicolas_upshift_promotors" /id="U2284" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.984015984015984" /psig="0.999000999001" /xcortree=2689 /SigmaFactorBS="ccatttcccctttgctgtcatatttaagTTTTTctgccatcc agtattTGTGATAAAATACCTTTGGCcataagtgtaccacgtttgccggcagcccgtt a" /listShort="S1121, sppA, yteJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2672348..2673151 /gene="ppnKB" /locus_tag="BSU_29540" /old_locus_tag="BSU29540" /EC_number="2.7.1.23" /function="16.7: Manage energy" /function="16.14: Store" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12897004, 16233726, 16511117, 25643072; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="inorganic polyphosphate/ATP-NAD kinase" /protein_id="NP_390832.1" /db_xref="EnsemblGenomes-Gn:BSU29540" /db_xref="EnsemblGenomes-Tr:CAB14932" /db_xref="GOA:O34934" /db_xref="InterPro:IPR002504" /db_xref="InterPro:IPR016064" /db_xref="InterPro:IPR017437" /db_xref="InterPro:IPR017438" /db_xref="SubtiList:BG13837" /db_xref="UniProtKB/Swiss-Prot:O34934" /translation="MTDQRRNVYFFHKQDQETNEQARSLTQLAEEHGFTVVNQHSDAN IIASIGGDGTFLQAVRKTNFRDDCLYVGITKKGKAHLYCDFHSDEREKMVDAMTFEQI EVRKYPLIEVTVDQASPFHCLNEVSIRSSIIKTFVMDVLIDDLHFETFRGDGMIISTP TGSTAYNKSVAGAVVDPLLPCMQVSELASLNNNTYRTLGSPFVLSSDRKLTLRVVQDG NEHPIIGLDNEALSTRNVKTIEIKLSNKKIKTVKLKDNSFWEKVKRTFL*" /label="ppnKB CDS" gene 2672348..2673151 /gene="ppnKB" /locus_tag="BSU_29540" /old_locus_tag="BSU29540" /label="ppnKB gene" downshifts 2673081 /Source="Nicolas_upshifts" /id="D1514" /incds=1 /nref=46 /ntot=222 /MaxReadThrough="5.39036" /MaxDrop="3.90238" /score="19.2746112" /energy="-13.8" /TU="U2283" /idTUdmin="U2283" /TUdmin="-124" /isTUend="FALSE" /label="downshifts" downshifts 2673139 /Source="Nicolas_upshifts" /id="D1515" /incds=0 /nref=6 /ntot=54 /MaxReadThrough="3.14676" /MaxDrop="4.64552" /score="19.2746112" /energy="-13.8" /TU="U2283" /idTUdmin="U2283" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" CDS complement(2673183..2674772) /gene="ytcJ" /locus_tag="BSU_29550" /old_locus_tag="BSU29550" /EC_number="3.5.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 19433221, 20386924, 24826896; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-substituted formamide deformylase, dihydropyrimidinase or isoaspartyl peptidase" /protein_id="NP_390833.1" /db_xref="EnsemblGenomes-Gn:BSU29550" /db_xref="EnsemblGenomes-Tr:CAB14933" /db_xref="GOA:O34355" /db_xref="InterPro:IPR011059" /db_xref="InterPro:IPR013108" /db_xref="InterPro:IPR032466" /db_xref="InterPro:IPR033932" /db_xref="SubtiList:BG13835" /db_xref="UniProtKB/Swiss-Prot:O34355" /translation="MKAIWHGGFIYTMLEEGDRTEAVYVEDGVIKGTGSYERLKEKYG SPETEEISLNGAVMFPGFVDSHLHLIGHGEKQLQLDLSALTSKDSILQAAKERERQLP KNDWLIGEGWNENQFETPDYLTKHDLDRLFPDRPVLLKRICRHAIAVNSAALQAAGIS RNTPDPDGGVIVKDANGEPTGLLFDKAQDLILKAVPPVSQHYVDEALTAAIKDCWTKG LTGGHSEDLSYYGDVSVPMKAYEKAAAGGKYPFRCHLLVHHEAVDRWEQLEKLSGPYV EFGAMKIFADGALGGRTALLKEPYQDDPSTNGVQVHDDETLGRLIRKAREKGMEVAVH AIGDLAFEKVLNAIEKHPPKNGRHDRLIHAQVLDNELIERAARMPIALDLQPHFVASD FPWVIDRLGKDRMKTAFAWKTLISKGILCAGGSDAPIEPVDPLLGIQSAVLRKSSHEQ NGPSYNESECLPVYEAIKLYTEGSAGIIYKEKSRGKIAEGYDADFTVLSGDPFAIDPA QLHLLEIKKTVINGQIVYEKS*" /label="ytcJ CDS" gene complement(2673183..2674772) /gene="ytcJ" /locus_tag="BSU_29550" /old_locus_tag="BSU29550" /label="ytcJ gene" downshifts complement(2673192) /Source="Nicolas_upshifts" /id="D1516" /incds=0 /nref=149 /ntot=255 /MaxReadThrough="2.61299" /MaxDrop="5.92403" /score="32.0110789" /energy="-13.8" /TU="NA" /idTUdmin="U2285" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(2674792..2676381) /gene="ytcI" /locus_tag="BSU_29560" /old_locus_tag="BSU29560" /EC_number="6.2.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acyl-coenzyme A synthetase" /protein_id="NP_390834.2" /db_xref="EnsemblGenomes-Gn:BSU29560" /db_xref="EnsemblGenomes-Tr:CAB14934" /db_xref="GOA:C0SPB0" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="SubtiList:BG13834" /db_xref="UniProtKB/Swiss-Prot:C0SPB0" /translation="MLKREDLIAPVQYNLVNEMEKFSAAGQKTALLWEDESGKQESWS YEKLMEETNKIGAALADLGFKKGDKLIVMVPRVLEAYAVYLAILKSGMVVIPCSEMLR AKDLEYRIEHAEVKGAIVYSEFIGAFRDVSTADKLITLSIGENDAGWKNLLSIEADGS QFKTADTTRDDMAFLSYTSGTTGQPKGVVHTHGWAFAHLKTSAGAWLDISEKDIVWAT AAPGWQKWVWSPFLAVLGSGATGFVYHGRFKAEKYLELLNRYKINVFCCTPTEYRLMA KVEGLKRFDLSALHSAVSAGEPLNREVIDVFQKHFGIKVRDGYGQTESTLLVGVLKDT PIKPGSMGKPTPGNQVEIINEDGEICKPGEVGDIAVHLSTPALFKEYFKDPERMKTQI RGDYFLTGDRARKDEEGYFWFESRNDDIIISSGYTIGPFEVEDALVKHPEVKECAVVA SPDEIRGSIVKAYVVLQNHEKRSDELVKMLQNHVKTITAPYKYPREIEFVESLPKTAS AKIRRVELRKREEQLKANKKA*" /label="ytcI CDS" gene complement(2674792..2676381) /gene="ytcI" /locus_tag="BSU_29560" /old_locus_tag="BSU29560" /label="ytcI gene" promotor_-10 complement(2676427..2676444) /Source="Nicolas_upshift_promotors" /id="U2285" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.34965034965035" /psig="0.871128871128871" /xcortree=1876 /SigmaFactorBS="aaaggaccagcggcctataaaatctaTGTTTACagaggttgc ttttagGCATATCCTTACGGAAAGagcctgtatttatgtataatgggtggagaaagtg a" /listShort="ytcI, ytcJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2676432) /Source="Nicolas_upshifts" /id="U2285" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.34965034965035" /psig="0.871128871128871" /xcortree=1876 /SigmaFactorBS="aaaggaccagcggcctataaaatctaTGTTTACagaggttgc ttttagGCATATCCTTACGGAAAGagcctgtatttatgtataatgggtggagaaagtg a" /listShort="ytcI, ytcJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2676460..2676466) /Source="Nicolas_upshift_promotors" /id="U2285" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.34965034965035" /psig="0.871128871128871" /xcortree=1876 /SigmaFactorBS="aaaggaccagcggcctataaaatctaTGTTTACagaggttgc ttttagGCATATCCTTACGGAAAGagcctgtatttatgtataatgggtggagaaagtg a" /listShort="ytcI, ytcJ" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2676559) /Source="Nicolas_upshifts" /id="D1517" /incds=0 /nref=242 /ntot=266 /MaxReadThrough="2.32229" /MaxDrop="9.17935" /score="30.5720337" /energy="-13.3" /TU="NA" /idTUdmin="U2287" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2676560..2676769) /gene="sspA" /locus_tag="BSU_29570" /old_locus_tag="BSU29570" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:2456528, 2468649, 3009398, 16707666" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2456528, 2468649, 3009398, 16707666; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein (alpha-type SASP)" /protein_id="NP_390835.1" /db_xref="EnsemblGenomes-Gn:BSU29570" /db_xref="EnsemblGenomes-Tr:CAB14935" /db_xref="GOA:P04831" /db_xref="InterPro:IPR001448" /db_xref="InterPro:IPR018126" /db_xref="SubtiList:BG10786" /db_xref="UniProtKB/Swiss-Prot:P04831" /translation="MANNNSGNSNNLLVPGAAQAIDQMKLEIASEFGVNLGADTTSRA NGSVGGEITKRLVSFAQQNMGGGQF*" /label="sspA CDS" gene complement(2676560..2676769) /gene="sspA" /locus_tag="BSU_29570" /old_locus_tag="BSU29570" /label="sspA gene" promotor_-35 2676765..2676769 /Source="Nicolas_upshift_promotors" /id="U2286" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=706 /SigmaFactorBS="tcgcttgagcagctcctggtactaaaaggttgttgctgttac ctgagttattgttaGCCATgtgtctcaCCTCCTTGTGAGTATagaatgtgtcaaaaca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2676769 /Source="Nicolas_upshifts" /id="U2286" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=706 /SigmaFactorBS="tcgcttgagcagctcctggtactaaaaggttgttgctgttac ctgagttattgttaGCCATgtgtctcaCCTCCTTGTGAGTATagaatgtgtcaaaaca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2676778..2676792 /Source="Nicolas_upshift_promotors" /id="U2286" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=706 /SigmaFactorBS="tcgcttgagcagctcctggtactaaaaggttgttgctgttac ctgagttattgttaGCCATgtgtctcaCCTCCTTGTGAGTATagaatgtgtcaaaaca c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2676790..2676801) /Source="Nicolas_upshift_promotors" /id="U2287" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=784 /SigmaFactorBS="tcaattttcagctcctgtatacaattaccaaagtttttcTGA ATGAagccatgtgttttgACACATTCTATActcacaaggaggtgagacacatggctaa c" /listShort="sspA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2676801) /Source="Nicolas_upshifts" /id="U2287" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=784 /SigmaFactorBS="tcaattttcagctcctgtatacaattaccaaagtttttcTGA ATGAagccatgtgttttgACACATTCTATActcacaaggaggtgagacacatggctaa c" /listShort="sspA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2676816..2676822) /Source="Nicolas_upshift_promotors" /id="U2287" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=784 /SigmaFactorBS="tcaattttcagctcctgtatacaattaccaaagtttttcTGA ATGAagccatgtgttttgACACATTCTATActcacaaggaggtgagacacatggctaa c" /listShort="sspA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2676863..2678068) /gene="trmG" /locus_tag="BSU_29580" /old_locus_tag="BSU29580" /EC_number="2.8.1.4" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 14757766, 16343540, 22773787, 24705700, 28287455" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 14757766, 16343540, 22773787, 24705700, 28287455; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="persulfide ATP pyrophosphatase involved in tRNA modification" /protein_id="NP_390836.2" /db_xref="EnsemblGenomes-Gn:BSU29580" /db_xref="EnsemblGenomes-Tr:CAB14936" /db_xref="GOA:O34595" /db_xref="InterPro:IPR003720" /db_xref="InterPro:IPR004114" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR020536" /db_xref="SubtiList:BG13827" /db_xref="UniProtKB/Swiss-Prot:O34595" /translation="MNYDHILIRFGEISTKGKNRKSFIERLKQNIRLVLKDYPNLKYF SNRDRMTITLNGEDPEALFPHLKQVFGIQSFSLAIKCDSRLDDIKATALKAIKDQYKP GDTFKVATKRAYKQFELDTNQMNAEIGGHILRNTEGLTVDVRNPDIPLRIEIREEATF LTIRDEKGAGGLPVGSAGKAMLMLSGGFDSPVAGFYAMKRGLSVEAVHFFSPPYTSER AKQKVMDLAKCLSRFGGSMTLHIVPFTKTQELIQKQIPENYTMTATRRLMLQIADRIR EKRNGLAIITGESLGQVASQTLESMYAINAVTSTPILRPLIAMDKTEIIEKSREIGTY ETSIQPFEDCCTIFTPPSPKTRPKKEKIEHFESFVDFEPYIQEAVDNIETMTLYSEQE ANDKFAELF*" /label="trmG CDS" gene complement(2676863..2678068) /gene="trmG" /locus_tag="BSU_29580" /old_locus_tag="BSU29580" /label="trmG gene" CDS complement(2678072..2679217) /gene="iscSB" /locus_tag="BSU_29590" /old_locus_tag="BSU29590" /EC_number="2.8.1.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 11443125, 13129955, 14757766, 16388576, 17237162, 14567704, 22773787, 28882201" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 11443125, 13129955, 14757766, 16388576, 17237162, 14567704, 22773787, 28882201; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cysteine desulfurase" /protein_id="NP_390837.1" /db_xref="EnsemblGenomes-Gn:BSU29590" /db_xref="EnsemblGenomes-Tr:CAB14937" /db_xref="GOA:O34874" /db_xref="InterPro:IPR000192" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR016454" /db_xref="SubtiList:BG12632" /db_xref="UniProtKB/Swiss-Prot:O34874" /translation="MIYLDNSSTTKPYDEVLNVYEQTSSRYFGNPSSLHRYGAETEQL LQAAKNQIKRSLGLKKYDIVFTSGATEANNAALKGAALSKIKTGKHIIATSIEHPSVT ESLEQLKELFGFDITYLSVNEDGFVSIEDLKAAIRPDTVLVSMMHVNNEVGSVQPIEA AGEVLKEHSNILFHVDYVQGIYKVPLAIEKAGIDLCSISGHKFHGLKGTGALIVKEGT RLIPLITGGSQQKGIRAGTEHTAGAVSLAKAINLASADFDTRLDTMTAVKELFMNRLS EIEGVVINTPQMNSAPHIINFSVPGIKAEVLLHMLEEQDIFVSTTSACSAKEHKPSKV LLEMGKGEQIAGSSIRISLNYSQTSDVAEPFMNALRPGIKKLREMMR*" /label="iscSB CDS" gene complement(2678072..2679217) /gene="iscSB" /locus_tag="BSU_29590" /old_locus_tag="BSU29590" /label="iscSB gene" S_feature complement(2679218..2680361) /Source="Nicolas_S_feature" /locus_tag="new_3028103_3029246_c" /HighExp="Diami, dia15, dia5, H2O2, G135, G180, G150, C30, Paraq, LBGstat" /AntisenseName="braB" /AntisenseCor="0.41502288403214899" /AntisenseRegPval="-11.9" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1123" promotor_-35 2679304..2679311 /Source="Nicolas_upshift_promotors" /id="U2288" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.741258741258741" /psig=1 /xcortree=2628 /SigmaFactorBS="gttaccataacaaaatttaatagaaaattacgaaaaactagt ATTGACTTctaatttttttaCCATATAATAAGATTTGTTCgtttcgtcatattatctg a" /listShort="S1124, braB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2679322..2679411 /Source="Nicolas_S_feature" /locus_tag="new_3028207_3028296" /HighExp="LPh, HPh, BMM, dia0, Heat, G180, Cold, LBGexp, C30, LPhT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1124" upshifts 2679322 /Source="Nicolas_upshifts" /id="U2288" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.741258741258741" /psig=1 /xcortree=2628 /SigmaFactorBS="gttaccataacaaaatttaatagaaaattacgaaaaactagt ATTGACTTctaatttttttaCCATATAATAAGATTTGTTCgtttcgtcatattatctg a" /listShort="S1124, braB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2679324..2679343 /Source="Nicolas_upshift_promotors" /id="U2288" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.741258741258741" /psig=1 /xcortree=2628 /SigmaFactorBS="gttaccataacaaaatttaatagaaaattacgaaaaactagt ATTGACTTctaatttttttaCCATATAATAAGATTTGTTCgtttcgtcatattatctg a" /listShort="S1124, braB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2679412..2680749 /gene="braB" /locus_tag="BSU_29600" /old_locus_tag="BSU29600" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11528000, 15849754, 16850406, 26473603" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11528000, 15849754, 16850406, 26473603; Product type t: transporter" /codon_start=1 /transl_table=11 /product="branched-chain amino acid-Na+ symporter" /protein_id="NP_390838.1" /db_xref="EnsemblGenomes-Gn:BSU29600" /db_xref="EnsemblGenomes-Tr:CAB14938" /db_xref="GOA:O34545" /db_xref="InterPro:IPR004685" /db_xref="SubtiList:BG12573" /db_xref="UniProtKB/Swiss-Prot:O34545" /translation="MKHSLPVKDTIIIGFMLFALFFGAGNMIYPPELGQAAGHNVWKA IGGFLLTGVGLPLLGIIAIALTGKDAKGLADKAHPVFGTIFTVVLYLSIGPLFAIPRT GTVSYEIGAVPFLTGVPERLSLLIFTLIFFGVTYYLALNPSKVVDRVGKILTPIKFTI ILIIVLKAIFTPMGGLGAVTEAYKGTPVFKGFLEGYKTMDALASIVFGVVVVNAVKSK GVTQSKALAAACIKAGVIAALGLTFIYVSLAYLGATSTNAIGPVGEGAKILSASSHYL FGSLGNIVLGAAITVACLTTSIGLVTSCGQYFSKLIPALSYKIVVTIVTLFSLIIANF GLAQIIAFSVPILSAIYPLAIVIIVLSFIDKIFKERREVYIACLIGTGLFSILDGIKA AGFSLGSLDVFLNANLPLYSLGIGWVLPGIVGAVIGYVLTLFIGPSKQLNEIS*" /label="braB CDS" gene 2679412..2680749 /gene="braB" /locus_tag="BSU_29600" /old_locus_tag="BSU29600" /label="braB gene" promotor_-10 complement(2680347..2680366) /Source="Nicolas_upshift_promotors" /id="U2289" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.949050949050949" /psig="0.998001998001998" /xcortree=1983 /SigmaFactorBS="gcgagtccgaaattcgcaatgatcaagctgaatAACGTGACa atcgtaacgacaaTTTTATATGATAATGCCGGAataagttttgaaaaatattggccgc a" /listShort="S1123, iscS, thiI, sspA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2680361) /Source="Nicolas_upshifts" /id="U2289" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.949050949050949" /psig="0.998001998001998" /xcortree=1983 /SigmaFactorBS="gcgagtccgaaattcgcaatgatcaagctgaatAACGTGACa atcgtaacgacaaTTTTATATGATAATGCCGGAataagttttgaaaaatattggccgc a" /listShort="S1123, iscS, thiI, sspA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2680381..2680388) /Source="Nicolas_upshift_promotors" /id="U2289" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.949050949050949" /psig="0.998001998001998" /xcortree=1983 /SigmaFactorBS="gcgagtccgaaattcgcaatgatcaagctgaatAACGTGACa atcgtaacgacaaTTTTATATGATAATGCCGGAataagttttgaaaaatattggccgc a" /listShort="S1123, iscS, thiI, sspA" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2680725 /Source="Nicolas_upshifts" /id="D1518" /incds=0 /nref=69 /ntot=174 /MaxReadThrough="1.86149" /MaxDrop="6.26921" /score="14.5905051" /energy="-15.2" /TU="U2288" /idTUdmin="U2288" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(2680844..2682532) /gene="ezrA" /locus_tag="BSU_29610" /old_locus_tag="BSU29610" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10449747, 15101985, 15317798, 16549676, 17718511, 17873055, 18363795, 19429628, 21401734, 24218584, 25954268, 28357277" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10449747, 15101985, 15317798, 16549676, 17718511, 17873055, 18363795, 19429628, 21401734, 24218584, 25954268, 28357277; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative regulator of FtsZ ring formation" /protein_id="NP_390839.1" /db_xref="EnsemblGenomes-Gn:BSU29610" /db_xref="EnsemblGenomes-Tr:CAB14939" /db_xref="GOA:O34894" /db_xref="InterPro:IPR010379" /db_xref="PDB:4UXV" /db_xref="SubtiList:BG13934" /db_xref="UniProtKB/Swiss-Prot:O34894" /translation="MEFVIGLLIVLLALFAAGYFFRKKIYAEIDRLESWKIEILNRSI VEEMSKIKHLKMTGQTEEFFEKWREEWDEIVTAHMPKVEELLYDAEENADKYRFKKAN QVLVHIDDLLTAAESSIEKILREISDLVTSEEKSREEIEQVRERYSKSRKNLLAYSHL YGELYDSLEKDLDEIWSGIKQFEEETEGGNYITARKVLLEQDRNLERLQSYIDDVPKL LADCKQTVPGQIAKLKDGYGEMKEKGYKLEHIQLDKELENLSNQLKRAEHVLMTELDI DEASAILQLIDENIQSVYQQLEGEVEAGQSVLSKMPELIIAYDKLKEEKEHTKAETEL VKESYRLTAGELGKQQAFEKRLDEIGKLLSSVKDKLDAEHVAYSLLVEEVASIEKQIE EVKKEHAEYRENLQALRKEELQARETLSNLKKTISETARLLKTSNIPGIPSHIQEMLE NAHHHIQETVNQLNELPLNMEEAGAHLKQAEDIVNRASRESEELVEQVILIEKIIQFG NRFRSQNHILSEQLKEAERRFYAFDYDDSYEIAAAAVEKAAPGAVEKIKADISA*" /label="ezrA CDS" gene complement(2680844..2682532) /gene="ezrA" /locus_tag="BSU_29610" /old_locus_tag="BSU29610" /label="ezrA gene" downshifts complement(2680845) /Source="Nicolas_upshifts" /id="D1519" /incds=0 /nref=224 /ntot=257 /MaxReadThrough="3.34218" /MaxDrop="5.3305" /score="9.25784495" /energy="-8.6" /TU="U2290" /idTUdmin="U2290" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" S_feature complement(2682533..2682638) /Source="Nicolas_S_feature" /locus_tag="new_3031418_3031523_c" /HighExp="C90, Lbtran, BMM, LBGtran, MG 150, S1, Lbexp, dia0, LBGexp, ferm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.975" /TUlongSig="NA" /TUlongPSig="NA" /label="S1125" promotor_-35 2682615..2682623 /Source="Nicolas_upshift_promotors" /id="U2291" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2258 /SigmaFactorBS="ttattcagaaagatttcaggatatgtattgagaaaaaCTGTC GTTTtcattgttatTATGATACCATGTAACAAACattttttgaccagaaatcaaaaac t" /listShort="S1126, hisJ, S1129, S1130, S1131, S1132, ytsP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2682626..2682645) /Source="Nicolas_upshift_promotors" /id="U2290" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig=1 /xcortree=2331 /SigmaFactorBS="cctgccgattttgcacaaaaagtttttgatttctgGTCaaaa aatgtttgttaCATGGTATCATAATAACAATgaaaacgacagtttttctcaatacata t" /listShort="S1125, ezrA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 2682634..2682653 /Source="Nicolas_upshift_promotors" /id="U2291" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2258 /SigmaFactorBS="ttattcagaaagatttcaggatatgtattgagaaaaaCTGTC GTTTtcattgttatTATGATACCATGTAACAAACattttttgaccagaaatcaaaaac t" /listShort="S1126, hisJ, S1129, S1130, S1131, S1132, ytsP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2682638) /Source="Nicolas_upshifts" /id="U2290" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig=1 /xcortree=2331 /SigmaFactorBS="cctgccgattttgcacaaaaagtttttgatttctgGTCaaaa aatgtttgttaCATGGTATCATAATAACAATgaaaacgacagtttttctcaatacata t" /listShort="S1125, ezrA" /GFF_Attribute="listLong" /label="upshifts" upshifts 2682638 /Source="Nicolas_upshifts" /id="U2291" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.985014985014985" /psig=1 /xcortree=2258 /SigmaFactorBS="ttattcagaaagatttcaggatatgtattgagaaaaaCTGTC GTTTtcattgttatTATGATACCATGTAACAAACattttttgaccagaaatcaaaaac t" /listShort="S1126, hisJ, S1129, S1130, S1131, S1132, ytsP" /GFF_Attribute="listLong" /label="upshifts" S_feature 2682639..2682728 /Source="Nicolas_S_feature" /locus_tag="new_3031524_3031613" /HighExp="HiOs, C90, dia5, T-5.40H, S1, T-3.40H, GM-0.1, GM 15, T3.0H, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1126" S_feature complement(2682640..2683199) /Source="Nicolas_S_feature" /locus_tag="new_3031525_3032084_c" /HighExp="Etha, Salt, Cold, G135, Lbstat, G180, G150, H2O2, Heat, Paraq" /AntisenseName="hisJ" /AntisenseCor="0.37018688255337001" /AntisenseRegPval="-9.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.975" /TUlongSig="NA" /TUlongPSig="NA" /label="S1127" promotor_-35 complement(2682661..2682663) /Source="Nicolas_upshift_promotors" /id="U2290" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig=1 /xcortree=2331 /SigmaFactorBS="cctgccgattttgcacaaaaagtttttgatttctgGTCaaaa aatgtttgttaCATGGTATCATAATAACAATgaaaacgacagtttttctcaatacata t" /listShort="S1125, ezrA" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2682729..2683535 /gene="hisK" /locus_tag="BSU_29620" /old_locus_tag="BSU29620" /EC_number="3.1.3.15" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10322033" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10322033; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="histidinol phosphate phosphatase" /protein_id="NP_390840.1" /db_xref="EnsemblGenomes-Gn:BSU29620" /db_xref="EnsemblGenomes-Tr:CAB14940" /db_xref="GOA:O34411" /db_xref="InterPro:IPR004013" /db_xref="InterPro:IPR010140" /db_xref="InterPro:IPR016195" /db_xref="SubtiList:BG13931" /db_xref="UniProtKB/Swiss-Prot:O34411" /translation="MQKRDGHIHTPFCPHGSNDTLRQYAEEALKKGFESITFTEHAPL PPSFTDPTPLKDSAMAQASLERYIHEISGLKKEYRGQLSIRTGLEVDYIAEFEDEITL FLDTYGPYLDDSILSVHFLRTDSSYLCLDYDEHTFKELISACGSIEAVYEQYYRSIYS SIVASLGVYKPKRVGHITLVQKFIKLFPYSMSEHIRGLVSLCLNAIEENGMELDFNTS GLRKTYAGGIYIEDWMLNEAKQKKIPLVFGSDAHQAGDVGYAYEAFLERC*" /label="hisK CDS" gene 2682729..2683535 /gene="hisK" /locus_tag="BSU_29620" /old_locus_tag="BSU29620" /label="hisK gene" promotor_-10 complement(2683203..2683222) /Source="Nicolas_upshift_promotors" /id="U2292" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.92007992007992" /psig="0.975024975024975" /xcortree=92 /SigmaFactorBS="aatttttggacgagtgtgatgtgaccgactcttttTGGCTTA TaaacgccgagaGATGCTACAATGGAAGAATAgatactccggtaatattgttcatata c" /listShort="S1127, S1125, ezrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2683216) /Source="Nicolas_upshifts" /id="U2292" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.92007992007992" /psig="0.975024975024975" /xcortree=92 /SigmaFactorBS="aatttttggacgagtgtgatgtgaccgactcttttTGGCTTA TaaacgccgagaGATGCTACAATGGAAGAATAgatactccggtaatattgttcatata c" /listShort="S1127, S1125, ezrA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2683234..2683241) /Source="Nicolas_upshift_promotors" /id="U2292" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.92007992007992" /psig="0.975024975024975" /xcortree=92 /SigmaFactorBS="aatttttggacgagtgtgatgtgaccgactcttttTGGCTTA TaaacgccgagaGATGCTACAATGGAAGAATAgatactccggtaatattgttcatata c" /listShort="S1127, S1125, ezrA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(2683485..2683531) /Source="Nicolas_S_feature" /locus_tag="new_3032370_3032416_c" /HighExp="M9-stat, T5.0H, LoTm, T4.0H, S2, BC, T3.30H, S4, T3.0H, B60" /AntisenseName="hisJ" /AntisenseCor="-0.46006853678527698" /AntisenseRegPval="-14.8" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1128" downshifts complement(2683507) /Source="Nicolas_upshifts" /id="D1520" /incds=0 /nref=51 /ntot=97 /MaxReadThrough="1.55523" /MaxDrop="6.84653" /score="-4.34170655" /energy="-10.5" /TU="NA" /idTUdmin="U2296" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2683532..2684155) /gene="refZ" /locus_tag="BSU_29630" /old_locus_tag="BSU29630" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11988534, 22730127, 26360512" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11988534, 22730127, 26360512; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of FtsZ defining the chromosome regioncaptured in the forespore" /protein_id="NP_390841.1" /db_xref="EnsemblGenomes-Gn:BSU29630" /db_xref="EnsemblGenomes-Tr:CAB14941" /db_xref="GOA:O34970" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR023772" /db_xref="SubtiList:BG13927" /db_xref="UniProtKB/Swiss-Prot:O34970" /translation="MKVSTKDKIIESAVMLFNQKGFSGTSVREIAKSADVNVAHISYY FKGKGGLMEHLVSEFYEGYSKTLETAASNISTQSTQEQLLQLVFDILSYQHNHRQLTR FVYREVTIDSTLIREIMSTYLMKEKYIFQLIIEEGEKQREYLTLPLPHFILQLKSLLM MPYLQPQYISEVLYMQPHEPYFYKMYFEEIKIWIRSVFRTGDVALTN*" /label="refZ CDS" gene complement(2683532..2684155) /gene="refZ" /locus_tag="BSU_29630" /old_locus_tag="BSU29630" /label="refZ gene" S_feature 2683536..2683878 /Source="Nicolas_S_feature" /locus_tag="new_3032421_3032763" /HighExp="C90, HiOs, Sw, dia5, GM-0.1, S1, MG 5, UNK1, MG 60, MG t5" /AntisenseName="yttP" /AntisenseCor="-0.79169109805002003" /AntisenseRegPval="-58.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1129" promotor_-35 2683856..2683863 /Source="Nicolas_upshift_promotors" /id="U2293" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig="0.999000999001" /xcortree=2053 /SigmaFactorBS="ggagtcaattgtgacttcccggtagacaaaacgagtTAATTG ACgatgattatgctgaTAGGATAAAATATCGAAAACcaattgaagaagctgttcctgc g" /listShort="S1130, S1131, S1132, ytsP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2683878..2683897 /Source="Nicolas_upshift_promotors" /id="U2293" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig="0.999000999001" /xcortree=2053 /SigmaFactorBS="ggagtcaattgtgacttcccggtagacaaaacgagtTAATTG ACgatgattatgctgaTAGGATAAAATATCGAAAACcaattgaagaagctgttcctgc g" /listShort="S1130, S1131, S1132, ytsP" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2683880..2684023 /Source="Nicolas_S_feature" /locus_tag="new_3032765_3032908" /HighExp="Diami, dia15, dia5, H2O2, C90, Paraq, Salt, Etha, Oxctl, Sw" /AntisenseName="yttP" /AntisenseCor="-0.81457903975257295" /AntisenseRegPval="-64.400000000000006" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1130" upshifts 2683880 /Source="Nicolas_upshifts" /id="U2293" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig="0.999000999001" /xcortree=2053 /SigmaFactorBS="ggagtcaattgtgacttcccggtagacaaaacgagtTAATTG ACgatgattatgctgaTAGGATAAAATATCGAAAACcaattgaagaagctgttcctgc g" /listShort="S1130, S1131, S1132, ytsP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2683995..2683999 /Source="Nicolas_upshift_promotors" /id="U2294" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.322677322677323" /psig="0.982017982017982" /xcortree=2757 /SigmaFactorBS="ctgtagccttcgtaaaactctgaaactaagTGTTCcatcaag cctcctttGCCTTTAAAATAGTAGGAGAtgtgcgcaacatttacatcagctgactttg c" /listShort="S1131, S1132, ytsP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2684015..2684034 /Source="Nicolas_upshift_promotors" /id="U2294" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.322677322677323" /psig="0.982017982017982" /xcortree=2757 /SigmaFactorBS="ctgtagccttcgtaaaactctgaaactaagTGTTCcatcaag cctcctttGCCTTTAAAATAGTAGGAGAtgtgcgcaacatttacatcagctgactttg c" /listShort="S1131, S1132, ytsP" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2684025..2684155 /Source="Nicolas_S_feature" /locus_tag="new_3032910_3033040" /HighExp="Diami, dia15, dia5, H2O2, Paraq, C90, HPh, LBGexp, Oxctl, Sw" /AntisenseName="yttP" /AntisenseCor="-0.82273476313537297" /AntisenseRegPval="-66.7" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.982, 0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1131" upshifts 2684025 /Source="Nicolas_upshifts" /id="U2294" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.322677322677323" /psig="0.982017982017982" /xcortree=2757 /SigmaFactorBS="ctgtagccttcgtaaaactctgaaactaagTGTTCcatcaag cctcctttGCCTTTAAAATAGTAGGAGAtgtgcgcaacatttacatcagctgactttg c" /listShort="S1131, S1132, ytsP" /GFF_Attribute="listLong" /label="upshifts" S_feature 2684157..2684281 /Source="Nicolas_S_feature" /locus_tag="new_3033042_3033166" /HighExp="Diami, dia5, dia15, H2O2, C90, BC, HiOs, Paraq, Sw, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigA" /TUshortPSig="0.598, 0.982, 0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1132" upshifts 2684157 /Source="Nicolas_upshifts" /id="U2295" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.582417582417582" /psig="0.598401598401598" /xcortree=570 /SigmaFactorBS="ttttggttaaaaagcatgacagcagattcaataattttgtct ttggtgcttactttcatacggctcactccttcctCTTGATACTATTCAAGCAGAaagc c" /listShort="S1132, ytsP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2684171..2684189) /Source="Nicolas_upshift_promotors" /id="U2296" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=448 /SigmaFactorBS="aaagttccggcttttctgccggcatttgtcgataagttcttA CAGGAACAgcggctttctGCTTGAATAGTATCAAGAGgaaggagtgagccgtatgaaa g" /listShort="yttP" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature 2684173..2684192 /Source="Nicolas_upshift_promotors" /id="U2295" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.582417582417582" /psig="0.598401598401598" /xcortree=570 /SigmaFactorBS="ttttggttaaaaagcatgacagcagattcaataattttgtct ttggtgcttactttcatacggctcactccttcctCTTGATACTATTCAAGCAGAaagc c" /listShort="S1132, ytsP" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2684189) /Source="Nicolas_upshifts" /id="U2296" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=448 /SigmaFactorBS="aaagttccggcttttctgccggcatttgtcgataagttcttA CAGGAACAgcggctttctGCTTGAATAGTATCAAGAGgaaggagtgagccgtatgaaa g" /listShort="yttP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2684200..2684208) /Source="Nicolas_upshift_promotors" /id="U2296" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=448 /SigmaFactorBS="aaagttccggcttttctgccggcatttgtcgataagttcttA CAGGAACAgcggctttctGCTTGAATAGTATCAAGAGgaaggagtgagccgtatgaaa g" /listShort="yttP" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2684282..2684773 /gene="msrC" /locus_tag="BSU_29640" /old_locus_tag="BSU29640" /EC_number="1.8.4.14" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17535911, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="free methionine-(R)-sulfoxide reductase" /protein_id="NP_390842.2" /db_xref="EnsemblGenomes-Gn:BSU29640" /db_xref="EnsemblGenomes-Tr:CAB14942" /db_xref="InterPro:IPR000614" /db_xref="InterPro:IPR003018" /db_xref="InterPro:IPR029016" /db_xref="SubtiList:BG13923" /db_xref="UniProtKB/Swiss-Prot:O34553" /translation="MFHVEKQSGDKEKDYQLLLKQLEAMTEDETDQIANYANASALLY HSLPEVNWAGFYFAKEEDGQLVLGPFQGLPACVRIPFGRGVCGTAYANGKVERIEDVN AFPGHIACDAASQSEIVLPIRVDGKIVGVLDIDSPVKNRFDEIDEKYLTQFAETLEKA LAQ*" /label="msrC CDS" gene 2684282..2684773 /gene="msrC" /locus_tag="BSU_29640" /old_locus_tag="BSU29640" /label="msrC gene" downshifts 2684752 /Source="Nicolas_upshifts" /id="D1521" /incds=0 /nref=72 /ntot=213 /MaxReadThrough="3.66093" /MaxDrop="6.50628" /score="34.0123402" /energy="-11.9" /TU="U2291,U2293,U2294" /idTUdmin="U2295" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2684811..2686550) /gene="dgcP" /locus_tag="BSU_29650" /old_locus_tag="BSU29650" /EC_number="2.7.7.65" /function="16.12: Sense" /function="16.3: Control" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:23893111" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23893111; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="diguanylate cyclase" /protein_id="NP_390843.1" /db_xref="EnsemblGenomes-Gn:BSU29650" /db_xref="EnsemblGenomes-Tr:CAB14943" /db_xref="InterPro:IPR000160" /db_xref="InterPro:IPR029016" /db_xref="InterPro:IPR029787" /db_xref="SubtiList:BG13918" /db_xref="UniProtKB/Swiss-Prot:O34325" /translation="MVEQTKDQLSAFHYHMLDFLLTKSEKVTFTDSFIWLTSAIQTYF STLCVSLTPSPSDFVTKLADGEARFSASKINASCYLIEDGSGRRFHLACRQDEEIPEG LPDVVASFLNQSMKQERLYNKTIYQKKIYKMTELFHSLLDQTDVLKQLLESLTSTFSL FEFSLFISHDQDQCLGIPAKELYMEGEKSDSFALKVYLSGDILRKNESVAYIPIKGQQ GTYGVLKAEGTGDSFLTDACLDEMSLLANAAGKAFENAQLYEQSKASIANLELINETS RRLNQRLTLTDTMNDLAVRMAESFQAEEVGFFHIDHFENLTLLPGSTAFFKEAKPSDF YNELKEKLYEGEKGVFIGNGQSVFGKAGYGSLMAAPMIQNDRLLGFAVLLKQELYAFT FEMYKLFQALIHHATLAVTNSMLRDRLEHLVKTDQLTELYSRAYLDEKIQYSMKIHQK GVFILVDIDNFKNVNDTYGHQTGDEILIQVASVIKSNIRKHDVGARWGGEELAIYLPN VPVAVGKRITERLVYAVRKNTKPEVTISCGISCWTTETKKSLKELVHEADEALYSAKR SGKNRLMIHDSIK*" /label="dgcP CDS" gene complement(2684811..2686550) /gene="dgcP" /locus_tag="BSU_29650" /old_locus_tag="BSU29650" /label="dgcP gene" downshifts complement(2684829) /Source="Nicolas_upshifts" /id="D1522" /incds=0 /nref=23 /ntot=178 /MaxReadThrough="3.68958" /MaxDrop="4.52201" /score="-0.637788006" /energy="-11.9" /TU="U2298" /idTUdmin="U2298" /TUdmin="-45" /isTUend="FALSE" /label="downshifts" promotor_-35 2686024..2686031 /Source="Nicolas_upshift_promotors" /id="U2297" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2821 /SigmaFactorBS="ttttccccttccatatacagctcttttgcaggaatcCCTAAA CAttggtcttgatcgTGCGATATAAATAAAGAAAactcaaaaagagaaaatgtgcttg t" /listShort="S1133, S1135, rpsD" /listLong="S1137" /label="promotor_-35" promotor_-10 2686045..2686063 /Source="Nicolas_upshift_promotors" /id="U2297" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2821 /SigmaFactorBS="ttttccccttccatatacagctcttttgcaggaatcCCTAAA CAttggtcttgatcgTGCGATATAAATAAAGAAAactcaaaaagagaaaatgtgcttg t" /listShort="S1133, S1135, rpsD" /listLong="S1137" /label="promotor_-10" upshifts 2686048 /Source="Nicolas_upshifts" /id="U2297" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2821 /SigmaFactorBS="ttttccccttccatatacagctcttttgcaggaatcCCTAAA CAttggtcttgatcgTGCGATATAAATAAAGAAAactcaaaaagagaaaatgtgcttg t" /listShort="S1133, S1135, rpsD" /listLong="S1137" /label="upshifts" S_feature 2686050..2686645 /Source="Nicolas_S_feature" /locus_tag="new_3034935_3035530" /HighExp="Cold, LBGstat, C30, Lbstat, GM 25, GM 10, GM 120, GM-0.1, GM 5, GM-0.2" /AntisenseName="ytrP" /AntisenseCor="-0.113221814489707" /AntisenseRegPval="-1.2" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1133" misc_feature complement(2686580..2686599) /Source="Nicolas_upshift_promotors" /id="U2298" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.897102897102897" /psig="0.999000999001" /xcortree=428 /SigmaFactorBS="aatttatttgttttgaagtcaaccattcctccattattgctt caccgttTATGATATAATAAACAAAAAttagtggtaaacttttaggtgataaaaacat g" /listShort="ytrP" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2686588) /Source="Nicolas_upshifts" /id="U2298" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.897102897102897" /psig="0.999000999001" /xcortree=428 /SigmaFactorBS="aatttatttgttttgaagtcaaccattcctccattattgctt caccgttTATGATATAATAAACAAAAAttagtggtaaacttttaggtgataaaaacat g" /listShort="ytrP" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2686590..2687423) /Source="Nicolas_S_feature" /locus_tag="new_3035475_3036308_c" /HighExp="Etha, S7, Gly, S8, M9-stat, Sw, G135, S6, BC, C30" /AntisenseName="rpsD" /AntisenseCor="-0.48019282175486899" /AntisenseRegPval="-16.2" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.965" /TUlongSig="NA" /TUlongPSig="NA" /label="S1134" promotor_-35 2686626..2686633 /Source="Nicolas_upshift_promotors" /id="U2299" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.837162837162837" /psig=1 /xcortree=2658 /SigmaFactorBS="ttattatatcataaacggtgaagcaataatggaggaatgGTT GACTTcaaaacaaataaaTTATATAATGACCTTTGTGTgaaatattgcagcctttttg t" /listShort="S1135, rpsD, S1137" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2686647..2686844 /Source="Nicolas_S_feature" /locus_tag="new_3035532_3035729" /HighExp="UNK1, Cold, HPh, C30, aero, LPhT, MG 25, Oxctl, Heat, GM 60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.139124" /TUshortSig="SigA, SigD" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1135" promotor_-10 2686647..2686666 /Source="Nicolas_upshift_promotors" /id="U2299" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.837162837162837" /psig=1 /xcortree=2658 /SigmaFactorBS="ttattatatcataaacggtgaagcaataatggaggaatgGTT GACTTcaaaacaaataaaTTATATAATGACCTTTGTGTgaaatattgcagcctttttg t" /listShort="S1135, rpsD, S1137" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2686647 /Source="Nicolas_upshifts" /id="U2299" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.837162837162837" /psig=1 /xcortree=2658 /SigmaFactorBS="ttattatatcataaacggtgaagcaataatggaggaatgGTT GACTTcaaaacaaataaaTTATATAATGACCTTTGTGTgaaatattgcagcctttttg t" /listShort="S1135, rpsD, S1137" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 2686704..2686836 /gene="ldsD" /locus_tag="BSU_misc_RNA_93" /product="ribosomal protein S4 leader mRNA sequence" /experiment="publication(s) with functional evidences, PMID:23611891" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23611891" /label="ldsD RNA" gene 2686704..2686836 /gene="ldsD" /locus_tag="BSU_misc_RNA_93" /label="ldsD gene" CDS 2686845..2687447 /gene="rpsD" /locus_tag="BSU_29660" /old_locus_tag="BSU29660" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1400226, 1699930, 1906866, 12682299, 23611891" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1400226, 1699930, 1906866, 12682299, 23611891; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S4 (BS4)" /protein_id="NP_390844.1" /db_xref="EnsemblGenomes-Gn:BSU29660" /db_xref="EnsemblGenomes-Tr:CAB14944" /db_xref="GOA:P21466" /db_xref="InterPro:IPR001912" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR005709" /db_xref="InterPro:IPR018079" /db_xref="InterPro:IPR022801" /db_xref="InterPro:IPR036986" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10372" /db_xref="UniProtKB/Swiss-Prot:P21466" /translation="MARYTGPSWKLSRRLGISLSGTGKELEKRPYAPGPHGPGQRKKL SEYGLQLQEKQKLRHMYGVNERQFRTLFDKAGKLAGKHGENFMILLDSRLDNVVYKLG LARTRRQARQLVNHGHILVDGSRVDIPSYLVKPGQTIGVREKSRNLSIIKESVEVNNF VPEYLTFDAEKLEGTFTRLPERSELAPEINEALIVEFYSR*" /label="rpsD CDS" gene 2686845..2687447 /gene="rpsD" /locus_tag="BSU_29660" /old_locus_tag="BSU29660" /label="rpsD gene" downshifts 2687370 /Source="Nicolas_upshifts" /id="D1523" /incds=1 /nref=1 /ntot=106 /MaxReadThrough="8.1141" /MaxDrop="2.9392" /score="31.6842" /energy="-13.6" /TU="U2297,U2299" /idTUdmin="U2297" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" S_feature complement(2687425..2687644) /Source="Nicolas_S_feature" /locus_tag="new_3036310_3036529_c" /HighExp="S5, Etha, S8, S6, S7, S4, BT, S3, M9-stat, B36" /AntisenseName="rpsD" /AntisenseCor="-0.59018291599064199" /AntisenseRegPval="-25.9" /CDS_PredictionProba="0.99997899999999995" /TUshortSig="SigB" /TUshortPSig="0.965" /TUlongSig="NA" /TUlongPSig="NA" /label="S1136" downshifts 2687433 /Source="Nicolas_upshifts" /id="D1524" /incds=0 /nref=135 /ntot=252 /MaxReadThrough="5.6866" /MaxDrop="6.10502" /score="31.6842" /energy="-13.6" /TU="U2299" /idTUdmin="U2297" /TUdmin=19 /isTUend="TRUE" /label="downshifts" downshifts complement(2687468) /Source="Nicolas_upshifts" /id="D1525" /incds=0 /nref=1 /ntot=23 /MaxReadThrough="4.84346" /MaxDrop="3.28594" /score="-4.07107651" /energy="-10.8" /TU="U2300" /idTUdmin="U2301" /TUdmin=264 /isTUend="FALSE" /label="downshifts" downshifts 2687480 /Source="Nicolas_upshifts" /id="D1526" /incds=0 /nref=1 /ntot=28 /MaxReadThrough="5.7799" /MaxDrop="4.26349" /score="31.6842" /energy="-13.6" /TU="U2299" /idTUdmin="U2297" /TUdmin=66 /isTUend="FALSE" /label="downshifts" S_feature 2687525..2687698 /Source="Nicolas_S_feature" /locus_tag="new_3036410_3036583" /HighExp="LBGtran, LoTm, C30, Cold, LBGexp, B60, dia15, B36, H2O2, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigD" /TUlongPSig=1 /label="S1137" promotor_-10 complement(2687640..2687658) /Source="Nicolas_upshift_promotors" /id="U2300" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.965034965034965" /psig="0.965034965034965" /xcortree=732 /SigmaFactorBS="agatcctttgccactgaaggcaaaggatcttttTGTTTACcg cataggaatgaaAGGAAAAGAGTATATTAGAtagggcaaacacgaccaatcaccacct t" /listShort="S1136, S1134, ytrP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2687652) /Source="Nicolas_upshifts" /id="U2300" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.965034965034965" /psig="0.965034965034965" /xcortree=732 /SigmaFactorBS="agatcctttgccactgaaggcaaaggatcttttTGTTTACcg cataggaatgaaAGGAAAAGAGTATATTAGAtagggcaaacacgaccaatcaccacct t" /listShort="S1136, S1134, ytrP" /GFF_Attribute="listLong" /label="upshifts" downshifts 2687656 /Source="Nicolas_upshifts" /id="D1527" /incds=0 /nref=7 /ntot=151 /MaxReadThrough="1.39547" /MaxDrop="6.12149" /score="26.4940291" /energy="-16.4" /TU="NA" /idTUdmin="U2299" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 complement(2687673..2687679) /Source="Nicolas_upshift_promotors" /id="U2300" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.965034965034965" /psig="0.965034965034965" /xcortree=732 /SigmaFactorBS="agatcctttgccactgaaggcaaaggatcttttTGTTTACcg cataggaatgaaAGGAAAAGAGTATATTAGAtagggcaaacacgaccaatcaccacct t" /listShort="S1136, S1134, ytrP" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2687718..2688986) /gene="tyrS" /locus_tag="BSU_29670" /old_locus_tag="BSU29670" /EC_number="6.1.1.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12547201, 15879350, 1735721, 9098057" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12547201, 15879350, 1735721, 9098057; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tyrosyl-tRNA synthetase" /protein_id="NP_390845.1" /db_xref="EnsemblGenomes-Gn:BSU29670" /db_xref="EnsemblGenomes-Tr:CAB14945" /db_xref="GOA:P22326" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR002305" /db_xref="InterPro:IPR002307" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR024088" /db_xref="InterPro:IPR024107" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG10371" /db_xref="UniProtKB/Swiss-Prot:P22326" /translation="MTNLLEDLSFRGLIQQMTDEEGLNKQLNEEKIRLYSGFDPTADS LHIGHLLPILTLRRFQLAGHHPIALVGGATGLIGDPSGKKAERTLNTADIVSEWSQKI KNQLSRFLDFEAAENPAVIANNFDWIGKMNVIDFLRDVGKNFGINYMLAKDTVSSRIE SGISYTEFSYMILQSYDFLNLYRDKNCKLQIGGSDQWGNITAGLELIRKSEEEGAKAF GLTIPLVTKADGTKFGKTEGGAIWLDKEKTSPYEFYQFWINTDDRDVVKYLKYFTFLS KEEIEAYAEKTETAPEKREAQKRLAEEVTSLVHGREALEQAINISQALFSGNIKELSA QDVKVGFKDVPSMEVDSTQELSLVDVLVQSKLSPSKRQAREDIQNGAVYINGERQTEI NYTLSGEDRIENQFTVLRRGKKKYFLVTYK*" /label="tyrS CDS" gene complement(2687718..2688986) /gene="tyrS" /locus_tag="BSU_29670" /old_locus_tag="BSU29670" /label="tyrS gene" downshifts complement(2687744) /Source="Nicolas_upshifts" /id="D1528" /incds=0 /nref=110 /ntot=357 /MaxReadThrough="2.2673" /MaxDrop="6.847" /score="22.5238672" /energy="-16.4" /TU="NA" /idTUdmin="U2301" /TUdmin="-12" /isTUend="TRUE" /label="downshifts" misc_RNA complement(2689010..2689283) /gene="tboY" /locus_tag="BSU_misc_RNA_83" /product="T-Box riboswitch specific of tyrosine tRNA ligase" /experiment="publication(s) with functional evidences, PMID:8045882, 10943892, 1317842, 9098041, 12165569, 12547201" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045882, 10943892, 1317842, 9098041, 12165569, 12547201; Product type n : RNA" /function="16.3: Control" /label="tboY RNA" gene complement(2689010..2689283) /gene="tboY" /locus_tag="BSU_misc_RNA_83" /label="tboY gene" S_feature complement(2689031..2689174) /Source="Nicolas_S_feature" /locus_tag="new_3037916_3038059_c" /HighExp="B60, Sw, B36, BC, M9-stat, T1.30H, S4, T4.0H, T2.30H, S7" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.40126600000000001" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1138" downshifts complement(2689074) /Source="Nicolas_upshifts" /id="D1529" /incds=0 /nref=58 /ntot=127 /MaxReadThrough="6.75235" /MaxDrop="6.49727" /score="45.7279775" /energy="-17.7" /TU="U2301,U2303" /idTUdmin="U2301" /TUdmin="-1342" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2689281..2689300) /Source="Nicolas_upshift_promotors" /id="U2301" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.587412587412587" /psig="0.998001998001998" /xcortree=599 /SigmaFactorBS="gagatctgtcaacaatggaggattaaaaggcggCGTTGACAc aggattttattTATGTTAAAAATGATATAGCttcatatgaaaaggtaaagattgagac a" /listShort="ytzK, S1138, tyrS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2689293) /Source="Nicolas_upshifts" /id="U2301" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.587412587412587" /psig="0.998001998001998" /xcortree=599 /SigmaFactorBS="gagatctgtcaacaatggaggattaaaaggcggCGTTGACAc aggattttattTATGTTAAAAATGATATAGCttcatatgaaaaggtaaagattgagac a" /listShort="ytzK, S1138, tyrS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2689313..2689320) /Source="Nicolas_upshift_promotors" /id="U2301" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.587412587412587" /psig="0.998001998001998" /xcortree=599 /SigmaFactorBS="gagatctgtcaacaatggaggattaaaaggcggCGTTGACAc aggattttattTATGTTAAAAATGATATAGCttcatatgaaaaggtaaagattgagac a" /listShort="ytzK, S1138, tyrS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2689328..2691046) /gene="acsA" /locus_tag="BSU_29680" /old_locus_tag="BSU29680" /EC_number="6.2.1.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7934817, 10986270, 11255012, 16855235, 18487328" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7934817, 10986270, 11255012, 16855235, 18487328; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetyl-CoA synthetase" /protein_id="NP_390846.1" /db_xref="EnsemblGenomes-Gn:BSU29680" /db_xref="EnsemblGenomes-Tr:CAB14946" /db_xref="GOA:P39062" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="SubtiList:BG10370" /db_xref="UniProtKB/Swiss-Prot:P39062" /translation="MNLKALPAIEGDHNLKNYEETYRHFDWAEAEKHFSWHETGKLNA AYEAIDRHAESFRKNKVALYYKDAKRDEKYTFKEMKEESNRAGNVLRRYGNVEKGDRV FIFMPRSPELYFIMLGAIKIGAIAGPLFEAFMEGAVKDRLENSEAKVVVTTPELLERI PVDKLPHLQHVFVVGGEAESGTNIINYDEAAKQESTRLDIEWMDKKDGFLLHYTSGST GTPKGVLHVHEAMIQQYQTGKWVLDLKEEDIYWCTADPGWVTGTVYGIFAPWLNGATN VIVGGRFSPESWYGTIEQLGVNVWYSAPTAFRMLMGAGDEMAAKYDLTSLRHVLSVGE PLNPEVIRWGHKVFNKRIHDTWWMTETGSQLICNYPCMDIKPGSMGKPIPGVEAAIVD NQGNELPPYRMGNLAIKKGWPSMMHTIWNNPEKYESYFMPGGWYVSGDSAYMDEEGYF WFQGRVDDVIMTSGERVGPFEVESKLVEHPAIAEAGVIGKPDPVRGEIIKAFIALREG FEPSDKLKEEIRLFVKQGLAAHAAPREIEFKDKLPKTRSGKIMRRVLKAWELNLPAGD LSTMED*" /label="acsA CDS" gene complement(2689328..2691046) /gene="acsA" /locus_tag="BSU_29680" /old_locus_tag="BSU29680" /label="acsA gene" promotor_-35 2691060..2691067 /Source="Nicolas_upshift_promotors" /id="U2302" /multdbtbs="-" /comp="M18" /sig="SigA" /pcomp="0.355644355644356" /psig="0.63936063936064" /xcortree=379 /SigmaFactorBS="gtaacgctttcaagttcatgcccaaacatcccCCTTTGCTga agttgtcacaatTATTATAGTATATATTCATAttcttctcaatttttaaaatataaac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2691074..2691093) /Source="Nicolas_upshift_promotors" /id="U2303" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.48051948051948" /psig="0.999000999001" /xcortree=357 /SigmaFactorBS="aataccaaattataaagcgttttcaacatggtttatatttta aaAATTGAGaagaatatgaataTATACTATAATAATTGTGACaacttcagcaaagggg g" /listShort="acsA, ytzK, S1138, tyrS" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 2691082..2691101 /Source="Nicolas_upshift_promotors" /id="U2302" /multdbtbs="-" /comp="M18" /sig="SigA" /pcomp="0.355644355644356" /psig="0.63936063936064" /xcortree=379 /SigmaFactorBS="gtaacgctttcaagttcatgcccaaacatcccCCTTTGCTga agttgtcacaatTATTATAGTATATATTCATAttcttctcaatttttaaaatataaac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2691088 /Source="Nicolas_upshifts" /id="U2302" /multdbtbs="-" /comp="M18" /sig="SigA" /pcomp="0.355644355644356" /psig="0.63936063936064" /xcortree=379 /SigmaFactorBS="gtaacgctttcaagttcatgcccaaacatcccCCTTTGCTga agttgtcacaatTATTATAGTATATATTCATAttcttctcaatttttaaaatataaac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2691097) /Source="Nicolas_upshifts" /id="U2303" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.48051948051948" /psig="0.999000999001" /xcortree=357 /SigmaFactorBS="aataccaaattataaagcgttttcaacatggtttatatttta aaAATTGAGaagaatatgaataTATACTATAATAATTGTGACaacttcagcaaagggg g" /listShort="acsA, ytzK, S1138, tyrS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2691107..2691113) /Source="Nicolas_upshift_promotors" /id="U2303" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.48051948051948" /psig="0.999000999001" /xcortree=357 /SigmaFactorBS="aataccaaattataaagcgttttcaacatggtttatatttta aaAATTGAGaagaatatgaataTATACTATAATAATTGTGACaacttcagcaaagggg g" /listShort="acsA, ytzK, S1138, tyrS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2691130..2691137 /Source="Nicolas_upshift_promotors" /id="U2304" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.615384615384615" /psig="0.993006993006993" /xcortree=496 /SigmaFactorBS="tattcatattcttctcaatttttaaaatataaaccaTGTTGA AAacgctttataattTGGTATTCTTAAAGAAGGCAtgtatttttgataagaattgatg g" /listShort="acuA, acuB, acuC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2691151..2691170 /Source="Nicolas_upshift_promotors" /id="U2304" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.615384615384615" /psig="0.993006993006993" /xcortree=496 /SigmaFactorBS="tattcatattcttctcaatttttaaaatataaaccaTGTTGA AAacgctttataattTGGTATTCTTAAAGAAGGCAtgtatttttgataagaattgatg g" /listShort="acuA, acuB, acuC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2691154 /Source="Nicolas_upshifts" /id="U2304" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.615384615384615" /psig="0.993006993006993" /xcortree=496 /SigmaFactorBS="tattcatattcttctcaatttttaaaatataaaccaTGTTGA AAacgctttataattTGGTATTCTTAAAGAAGGCAtgtatttttgataagaattgatg g" /listShort="acuA, acuB, acuC" /GFF_Attribute="listLong" /label="upshifts" CDS 2691207..2691839 /gene="acuA" /locus_tag="BSU_29690" /old_locus_tag="BSU29690" /EC_number="2.3.1.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:7934817, 10368162, 10809684, 11274109, 16855235, 18487328, 19136592, 24957627" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7934817, 10368162, 10809684, 11274109, 16855235, 18487328, 19136592, 24957627; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein acetyltransferase (acetylates AcsA)" /protein_id="NP_390847.1" /db_xref="EnsemblGenomes-Gn:BSU29690" /db_xref="EnsemblGenomes-Tr:CAB14947" /db_xref="GOA:P39065" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="InterPro:IPR024699" /db_xref="SubtiList:BG10369" /db_xref="UniProtKB/Swiss-Prot:P39065" /translation="MEHHKTYHSANIKTATGSLLIEGPVSPEDLAGYEFHKDLTAFRP PREQHEALVDIAGLPEGRIIIARDGRTIVGYVTYLYPDPLERWSEGNMEDLIELGAIE VAPDYRGCAVGKTLLTVSMMDEQMENYIVMTTEYYWHWDLKGMKKDVWEYRKIMEKMM NAGGLVWFATDEPEISSHPANCLMARIGKNVSQESIEQFDRLRFYHRYMY*" /label="acuA CDS" gene 2691207..2691839 /gene="acuA" /locus_tag="BSU_29690" /old_locus_tag="BSU29690" /label="acuA gene" promotor_-35 2691412..2691420 /Source="Nicolas_upshift_promotors" /id="U2305" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.931068931068931" /psig="0.931068931068931" /xcortree=1263 /SigmaFactorBS="tcccgaagggcgcattattattgccagagacgGCCGAACCAt tgtcggctatgtCACGTATTTATATCCTGACCcgctcgaaagatggtctgaaggaaat a" /listShort="acuB, acuC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2691434..2691453 /Source="Nicolas_upshift_promotors" /id="U2305" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.931068931068931" /psig="0.931068931068931" /xcortree=1263 /SigmaFactorBS="tcccgaagggcgcattattattgccagagacgGCCGAACCAt tgtcggctatgtCACGTATTTATATCCTGACCcgctcgaaagatggtctgaaggaaat a" /listShort="acuB, acuC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2691440 /Source="Nicolas_upshifts" /id="U2305" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.931068931068931" /psig="0.931068931068931" /xcortree=1263 /SigmaFactorBS="tcccgaagggcgcattattattgccagagacgGCCGAACCAt tgtcggctatgtCACGTATTTATATCCTGACCcgctcgaaagatggtctgaaggaaat a" /listShort="acuB, acuC" /GFF_Attribute="listLong" /label="upshifts" CDS 2691866..2692510 /gene="acuB" /locus_tag="BSU_29700" /old_locus_tag="BSU29700" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:7934817, 10368162, 10809684, 11274109, 16855235, 18487328" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7934817, 10368162, 10809684, 11274109, 16855235, 18487328; Product type f : factor" /codon_start=1 /transl_table=11 /product="component of the acetyl-coenzyme A synthetase regulation pathway" /protein_id="NP_390848.1" /db_xref="EnsemblGenomes-Gn:BSU29700" /db_xref="EnsemblGenomes-Tr:CAB14948" /db_xref="GOA:P39066" /db_xref="InterPro:IPR000644" /db_xref="SubtiList:BG10368" /db_xref="UniProtKB/Swiss-Prot:P39066" /translation="MIVEQIMKRDVITLTKTDTLETAICKLKEFHIRHLPVVDEERHV IGMITDRDMKQASPSIFEENKRSLFLTRSVDSIMKKDVVCAHPLDFVEEISAVFYEHG IGCLPVVHHQKLIGILTKTDLLRTFVKLTGADQPGSQIEIKVNDITKSLAEISSLCQD LQVKILSVLVYPHDDPGVKVLVFRVKTMNPLPFLQALQRNGHHVVWPSEQRDLL*" /label="acuB CDS" gene 2691866..2692510 /gene="acuB" /locus_tag="BSU_29700" /old_locus_tag="BSU29700" /label="acuB gene" CDS 2692507..2693670 /gene="acuC" /locus_tag="BSU_29710" /old_locus_tag="BSU29710" /EC_number="3.5.1.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:7934817, 10368162, 10809684, 11274109, 16855235, 18487328" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7934817, 10368162, 10809684, 11274109, 16855235, 18487328; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="protein deacetylase (regulates AcsA activity)" /protein_id="NP_390849.1" /db_xref="EnsemblGenomes-Gn:BSU29710" /db_xref="EnsemblGenomes-Tr:CAB14949" /db_xref="GOA:P39067" /db_xref="InterPro:IPR000286" /db_xref="InterPro:IPR003085" /db_xref="InterPro:IPR023696" /db_xref="InterPro:IPR023801" /db_xref="InterPro:IPR037138" /db_xref="SubtiList:BG10367" /db_xref="UniProtKB/Swiss-Prot:P39067" /translation="MRDSVFIYSPSYQTYMFHQEHPFNQQRVLLTYDLLKTINAFDDG DIVTPRLASEEELSLVHTDDYIQAVKLAGAGKLPAEEGESYGLGTEDTPVFAGMHEAA SLLVGGTLTAADWVMSGQALHAANLGGGLHHGFRGRASGFCIYNDSAVAIQYIQKKYS ARVLYIDTDAHHGDGVQFTFYDNPDVCTLSIHETGRYLFPGTGQIQEKGSGKGYGYSF NIPLDAFTEDDSFLEAYRTAASEVAAYFEPDVIISQNGADAHYYDPLTHLSATINIYE EIPRLAHTLAHQYCGGKWIAVGGGGYDIWRVVPRAWARIWLEMKGIDPGHEIPPEWIV KWQKQCPVALPSSWSDPADLYPPIPRKPEITEKNAQTVSKALYAIRSEQQRTK*" /label="acuC CDS" gene 2692507..2693670 /gene="acuC" /locus_tag="BSU_29710" /old_locus_tag="BSU29710" /label="acuC gene" downshifts 2693661 /Source="Nicolas_upshifts" /id="D1530" /incds=0 /nref=98 /ntot=231 /MaxReadThrough="0.530530000000001" /MaxDrop="6.5095" /score="10.9528437" /energy="-9.1" /TU="NA" /idTUdmin="U2304" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2693681..2694409) /gene="motS" /locus_tag="BSU_29720" /old_locus_tag="BSU29720" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9260952, 15306009, 16095621, 16547058, 23049994, 28378843, 29109979" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9260952, 15306009, 16095621, 16547058, 23049994, 28378843, 29109979; Product type t: transporter" /codon_start=1 /transl_table=11 /product="sodium channel stator-force generator peptidoglycan binding subunit of flagellar rotation" /protein_id="NP_390850.1" /db_xref="EnsemblGenomes-Gn:BSU29720" /db_xref="EnsemblGenomes-Tr:CAB14950" /db_xref="GOA:P39064" /db_xref="InterPro:IPR006665" /db_xref="InterPro:IPR025713" /db_xref="InterPro:IPR036737" /db_xref="SubtiList:BG10366" /db_xref="UniProtKB/Swiss-Prot:P39064" /translation="MKLRRERFERRNGSGKNSQSSSSWMVTFTDLITLILVFFILLFS MSQIDLQKFKAAVDSIQKEGNGLQPDQTSIEKKNTSPSDTKKQEDQQDQLLKKVNTYI KDNHLKAQMTAKRDERGVVLVLQEAVLFDTGEAKVLKNAETLLHQIAVLLQTIPNDIQ VEGHTDSRNISTYRYPSNWELSAARASGVIQYFTSKEKLPSKRFIAVGYADTKPVKDN KTNEHMKENRRVEIVIKKSKTTSS*" /label="motS CDS" gene complement(2693681..2694409) /gene="motS" /locus_tag="BSU_29720" /old_locus_tag="BSU29720" /label="motS gene" downshifts complement(2693717) /Source="Nicolas_upshifts" /id="D1531" /incds=0 /nref=37 /ntot=149 /MaxReadThrough="1.3853" /MaxDrop="3.98206" /score="4.77211813" /energy="-6.9" /TU="NA" /idTUdmin="U2307" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2694399..2695217) /gene="motP" /locus_tag="BSU_29730" /old_locus_tag="BSU29730" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9260952, 15306009, 16095621, 16547058, 23049994, 28378843, 29109979" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9260952, 15306009, 16095621, 16547058, 23049994, 28378843, 29109979; Product type t: transporter" /codon_start=1 /transl_table=11 /product="sodium channel stator-force generator subunit offlagellar rotation" /protein_id="NP_390851.1" /db_xref="EnsemblGenomes-Gn:BSU29730" /db_xref="EnsemblGenomes-Tr:CAB14951" /db_xref="GOA:P39063" /db_xref="InterPro:IPR000540" /db_xref="InterPro:IPR002898" /db_xref="SubtiList:BG10365" /db_xref="UniProtKB/Swiss-Prot:P39063" /translation="MKRFDYLTPVGFVLGTIIIVIGIISGSGVSGFRSFLDLTSFFIV TGGLCAAVFISFPPSELKKAPSVLKQAFIRQEDNVKDLVKTFVSLSDHARKHGLLSLD DQAREIKDPFLKKGLLLAIDGWDEETIRLVMDSEIAAMEERHRKGRRVFEKAGEFAPA WGMIGTLVGLVLMLKNLNDPHMLGPNMAIALLTTLYGSLLANMVFNPIAAKLEEKTES EIFIKQVMVEGIIGVQSGKNPRNLESQLVVFSSREEWQKQPKQVKTKKGSVHEA*" /label="motP CDS" gene complement(2694399..2695217) /gene="motP" /locus_tag="BSU_29730" /old_locus_tag="BSU29730" /label="motP gene" CDS complement(2695280..2696284) /gene="ccpA" /locus_tag="BSU_29740" /old_locus_tag="BSU29740" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11931564, 14665673, 16316990, 17085448, 17827291, 18757537, 19202299, 22001508, 22512862, 23123903, 25157083, 26712933, 28617843" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11931564, 14665673, 16316990, 17085448, 17827291, 18757537, 19202299, 22001508, 22512862, 23123903, 25157083, 26712933, 28617843; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of catabolite repression (Lacl family)" /protein_id="NP_390852.1" /db_xref="EnsemblGenomes-Gn:BSU29740" /db_xref="EnsemblGenomes-Tr:CAB14952" /db_xref="GOA:P25144" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR006377" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="PDB:1ZVV" /db_xref="PDB:2FEP" /db_xref="PDB:3OQM" /db_xref="PDB:3OQN" /db_xref="PDB:3OQO" /db_xref="SubtiList:BG10376" /db_xref="UniProtKB/Swiss-Prot:P25144" /translation="MSNITIYDVAREANVSMATVSRVVNGNPNVKPTTRKKVLEAIER LGYRPNAVARGLASKKTTTVGVIIPDISSIFYSELARGIEDIATMYKYNIILSNSDQN MEKELHLLNTMLGKQVDGIVFMGGNITDEHVAEFKRSPVPIVLAASVEEQEETPSVAI DYEQAIYDAVKLLVDKGHTDIAFVSGPMAEPINRSKKLQGYKRALEEANLPFNEQFVA EGDYTYDSGLEALQHLMSLDKKPTAILSATDEMALGIIHAAQDQGLSIPEDLDIIGFD NTRLSLMVRPQLSTVVQPTYDIGAVAMRLLTKLMNKEPVEEHIVELPHRIELRKSTKS *" /label="ccpA CDS" gene complement(2695280..2696284) /gene="ccpA" /locus_tag="BSU_29740" /old_locus_tag="BSU29740" /label="ccpA gene" downshifts complement(2695297) /Source="Nicolas_upshifts" /id="D1532" /incds=0 /nref=62 /ntot=239 /MaxReadThrough="4.60553" /MaxDrop="4.6531" /score="5.3377823" /energy="-13.2" /TU="U2307,U2308,U2309" /idTUdmin="U2306" /TUdmin=3 /isTUend="TRUE" /label="downshifts" misc_feature complement(2696319..2696338) /Source="Nicolas_upshift_promotors" /id="U2306" /multdbtbs="-" /comp="M5" /sig="SigA" /pcomp="0.366633366633367" /psig="0.577422577422577" /xcortree=1443 /SigmaFactorBS="cgcttacaaatcataaacgacataaattcggacattatgaca tttctctacataaaGTGTTTATGCTATAGATAAGgataagtgtatccagtaaaaggag t" /listShort="ccpA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2696334) /Source="Nicolas_upshifts" /id="U2306" /multdbtbs="-" /comp="M5" /sig="SigA" /pcomp="0.366633366633367" /psig="0.577422577422577" /xcortree=1443 /SigmaFactorBS="cgcttacaaatcataaacgacataaattcggacattatgaca tttctctacataaaGTGTTTATGCTATAGATAAGgataagtgtatccagtaaaaggag t" /listShort="ccpA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2696336..2696444) /Source="Nicolas_S_feature" /locus_tag="new_3045221_3045329_c" /HighExp="Oxctl, H2O2, Paraq, MG-0.1, MG-0.2, G150, GM 15, Diami, LBGexp, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigB" /TUshortPSig="0.988, 1, 0.974, 1" /TUlongSig="SigH" /TUlongPSig=1 /label="S1139" promotor_-10 complement(2696444..2696463) /Source="Nicolas_upshift_promotors" /id="U2307" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.377622377622378" /psig="0.988011988011988" /xcortree=2336 /SigmaFactorBS="tagttataaaaaccaagtataCGTTTTCatcatctataaaaA CGTGTATAATTTCATGAGAagtaattaaatttgatgaataatgaaaaataatgtacac t" /listShort="S1139, ccpA, ytxD, ytxE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2696444) /Source="Nicolas_upshifts" /id="U2307" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.377622377622378" /psig="0.988011988011988" /xcortree=2336 /SigmaFactorBS="tagttataaaaaccaagtataCGTTTTCatcatctataaaaA CGTGTATAATTTCATGAGAagtaattaaatttgatgaataatgaaaaataatgtacac t" /listShort="S1139, ccpA, ytxD, ytxE" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2696446..2696511) /Source="Nicolas_S_feature" /locus_tag="new_3045331_3045396_c" /HighExp="BMM, GM 120, Diami, GM 90, M/G, GM 25, M9-exp, HiTm, G180, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigB" /TUshortPSig="1, 0.974, 1" /TUlongSig="SigH" /TUlongPSig=1 /label="S1140" promotor_-35 complement(2696477..2696483) /Source="Nicolas_upshift_promotors" /id="U2307" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.377622377622378" /psig="0.988011988011988" /xcortree=2336 /SigmaFactorBS="tagttataaaaaccaagtataCGTTTTCatcatctataaaaA CGTGTATAATTTCATGAGAagtaattaaatttgatgaataatgaaaaataatgtacac t" /listShort="S1139, ccpA, ytxD, ytxE" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2696557) /Source="Nicolas_upshifts" /id="D1533" /incds=0 /nref=66 /ntot=188 /MaxReadThrough="6.10221" /MaxDrop="6.29667" /score="46.0872381" /energy="-11.3" /TU="U2308,U2309,U2310" /idTUdmin="U2311" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(2696560..2697636) /gene="aroX" /locus_tag="BSU_29750" /old_locus_tag="BSU29750" /EC_number="2.5.1.54" /EC_number="5.4.99.5" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:4200844, 7496534, 11444986, 16339761, 28743924" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4200844, 7496534, 11444986, 16339761, 28743924; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional chorismate mutase type II-isozyme 3(regulatory domain); 3-deoxy-D-arabino-heptulosonate7-phosphate synthase" /protein_id="NP_390853.1" /db_xref="EnsemblGenomes-Gn:BSU29750" /db_xref="EnsemblGenomes-Tr:CAB14953" /db_xref="GOA:P39912" /db_xref="InterPro:IPR002701" /db_xref="InterPro:IPR006218" /db_xref="InterPro:IPR006268" /db_xref="InterPro:IPR010954" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR036979" /db_xref="PDB:5GMU" /db_xref="PDB:5GO2" /db_xref="SubtiList:BG10375" /db_xref="UniProtKB/Swiss-Prot:P39912" /translation="MSNTELELLRQKADELNLQILKLINERGNVVKEIGKAKEAQGVN RFDPVRERTMLNNIIENNDGPFENSTIQHIFKEIFKAGLELQEEDHSKALLVSRKKKP EDTIVDIKGEKIGDGQQRFIVGPCAVESYEQVAEVAAAAKKQGIKILRGGAFKPRTSP YDFQGLGVEGLQILKRVADEFDLAVISEIVTPAHIEEALDYIDVIQIGARNMQNFELL KAAGAVKKPVLLKRGLAATISEFINAAEYIMSQGNDQIILCERGIRTYETATRNTLDI SAVPILKQETHLPVFVDVTHSTGRRDLLLPTAKAALAIGADGVMAEVHPDPSVALSDS AQQMAIPEFEKWLNELKPMVKVNA*" /label="aroX CDS" gene complement(2696560..2697636) /gene="aroX" /locus_tag="BSU_29750" /old_locus_tag="BSU29750" /label="aroX gene" promotor_-10 complement(2697677..2697696) /Source="Nicolas_upshift_promotors" /id="U2308" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.908091908091908" /psig=1 /xcortree=3058 /SigmaFactorBS="taataaagtagagtttttataaaattttttgtatttcagTAT TTCCAtttggaattacttaTAGTAAGATGCATGATAACTacaaaataaaaaatgaatg t" /listShort="aroA, S1140, S1139, ccpA, ytxD" /listLong="ytxE" /label="promotor_-10" upshifts complement(2697697) /Source="Nicolas_upshifts" /id="U2308" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.908091908091908" /psig=1 /xcortree=3058 /SigmaFactorBS="taataaagtagagtttttataaaattttttgtatttcagTAT TTCCAtttggaattacttaTAGTAAGATGCATGATAACTacaaaataaaaaatgaatg t" /listShort="aroA, S1140, S1139, ccpA, ytxD" /listLong="ytxE" /label="upshifts" S_feature complement(2697699..2697799) /Source="Nicolas_S_feature" /locus_tag="new_3046584_3046684_c" /HighExp="Lbtran, BMM, dia5, GM 25, GM 90, M9-exp, MG 150, Diami, MG-0.2, SMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB, SigH" /TUshortPSig="0.974, 1, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S1141" promotor_-35 complement(2697711..2697718) /Source="Nicolas_upshift_promotors" /id="U2308" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.908091908091908" /psig=1 /xcortree=3058 /SigmaFactorBS="taataaagtagagtttttataaaattttttgtatttcagTAT TTCCAtttggaattacttaTAGTAAGATGCATGATAACTacaaaataaaaaatgaatg t" /listShort="aroA, S1140, S1139, ccpA, ytxD" /listLong="ytxE" /label="promotor_-35" downshifts 2697733 /Source="Nicolas_upshifts" /id="D1534" /incds=0 /nref=1 /ntot=9 /MaxReadThrough="2.07872" /MaxDrop="3.23284" /score="1.10447256" /energy="-7.6" /TU="NA" /idTUdmin="U2304" /TUdmin=4071 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2697787..2697806) /Source="Nicolas_upshift_promotors" /id="U2309" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.453546453546454" /psig="0.974025974025974" /xcortree=3018 /SigmaFactorBS="agatatcatctggcgcttttttttgtaaaaaacCCTTGAAca ttgccctcacaTCATGTAGGATAGCTTCATAgattactttatcacttaaaagcgtttg g" /listShort="S1141, aroA, S1140, S1139, ccpA, ytxD, ytxE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2697799) /Source="Nicolas_upshifts" /id="U2309" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.453546453546454" /psig="0.974025974025974" /xcortree=3018 /SigmaFactorBS="agatatcatctggcgcttttttttgtaaaaaacCCTTGAAca ttgccctcacaTCATGTAGGATAGCTTCATAgattactttatcacttaaaagcgtttg g" /listShort="S1141, aroA, S1140, S1139, ccpA, ytxD, ytxE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2697820..2697826) /Source="Nicolas_upshift_promotors" /id="U2309" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.453546453546454" /psig="0.974025974025974" /xcortree=3018 /SigmaFactorBS="agatatcatctggcgcttttttttgtaaaaaacCCTTGAAca ttgccctcacaTCATGTAGGATAGCTTCATAgattactttatcacttaaaagcgtttg g" /listShort="S1141, aroA, S1140, S1139, ccpA, ytxD, ytxE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2697872..2698198) /gene="brxJ" /locus_tag="BSU_29760" /old_locus_tag="BSU29760" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8733232, 22938038, 25852656" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8733232, 22938038, 25852656; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bacilliredoxin involved in debacillithiolation" /protein_id="NP_390854.1" /db_xref="EnsemblGenomes-Gn:BSU29760" /db_xref="EnsemblGenomes-Tr:CAB14954" /db_xref="InterPro:IPR022551" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG10373" /db_xref="UniProtKB/Swiss-Prot:P39914" /translation="MAKQLIQSEEEFKRIAEQEGVFVFLKHSTTCPISQAAFHEFDAF ANQHEDVPAYYLQVQEARPLSNFIAETYGVKHESPQIFIIQNGEVKWHTSHSQITEAA IEQHLS*" /label="brxJ CDS" gene complement(2697872..2698198) /gene="brxJ" /locus_tag="BSU_29760" /old_locus_tag="BSU29760" /label="brxJ gene" downshifts complement(2697881) /Source="Nicolas_upshifts" /id="D1535" /incds=0 /nref=144 /ntot=286 /MaxReadThrough="7.09736" /MaxDrop="5.96753" /score="13.8032115" /energy="-7.6" /TU="U2310,U2311" /idTUdmin="U2313" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" CDS complement(2698222..2698677) /gene="ytxH" /locus_tag="BSU_29770" /old_locus_tag="BSU29770" /function="16.6: Maintain" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 8733232, 16291680" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390855.2" /db_xref="EnsemblGenomes-Gn:BSU29770" /db_xref="EnsemblGenomes-Tr:CAB14955" /db_xref="InterPro:IPR024623" /db_xref="SubtiList:BG10975" /db_xref="UniProtKB/Swiss-Prot:P40780" /translation="MSKDGINSKDFLIGTLIGGIIGATTALFLAPKSGKELRDDLGSQ AVALRDKTDKMTADAKEKGTQYVSIAKDKTSNITQLVADQSGQIMNKVKDLRDRSKSD KTDSSTAMQDMREEAMQAADETKDQVLQTKEDVKDELKDAQKQAEQLNR*" /label="ytxH CDS" gene complement(2698222..2698677) /gene="ytxH" /locus_tag="BSU_29770" /old_locus_tag="BSU29770" /label="ytxH gene" CDS complement(2698708..2699130) /gene="ytxG" /locus_tag="BSU_29780" /old_locus_tag="BSU29780" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8733232, 22720735, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8733232, 22720735, 26735940; Product type f: factor" /codon_start=1 /transl_table=11 /product="general stress protein" /protein_id="NP_390856.2" /db_xref="EnsemblGenomes-Gn:BSU29780" /db_xref="EnsemblGenomes-Tr:CAB14956" /db_xref="GOA:P40779" /db_xref="InterPro:IPR009293" /db_xref="SubtiList:BG10974" /db_xref="UniProtKB/Swiss-Prot:P40779" /translation="MIIILYLSVALIAVAFLVLVIYLSKTLKSLQLTLKNVASTLEGL EGQMKGITTETAELLHKTNRLAEDIQEKSEKLNTVVHAVQGVGASVQQFNTSMKQAAG SVSASVRENQDKINQVVTWSQAAMEIWEKWKQKKKSAL*" /label="ytxG CDS" gene complement(2698708..2699130) /gene="ytxG" /locus_tag="BSU_29780" /old_locus_tag="BSU29780" /label="ytxG gene" promotor_-10 complement(2699151..2699169) /Source="Nicolas_upshift_promotors" /id="U2310" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=264 /SigmaFactorBS="taacggagaatagtatgtatacagcccagtacacaTGTTTAT gattgaagaaaacGGGTAAACAGCAGTATATCctgcagcaaggaggtttgagatgatt a" /listShort="ytxG, ytxH, ytxJ, S1141, aroA, S1140, S1139, ccpA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2699164) /Source="Nicolas_upshifts" /id="U2310" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=264 /SigmaFactorBS="taacggagaatagtatgtatacagcccagtacacaTGTTTAT gattgaagaaaacGGGTAAACAGCAGTATATCctgcagcaaggaggtttgagatgatt a" /listShort="ytxG, ytxH, ytxJ, S1141, aroA, S1140, S1139, ccpA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2699183..2699189) /Source="Nicolas_upshift_promotors" /id="U2310" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=264 /SigmaFactorBS="taacggagaatagtatgtatacagcccagtacacaTGTTTAT gattgaagaaaacGGGTAAACAGCAGTATATCctgcagcaaggaggtttgagatgatt a" /listShort="ytxG, ytxH, ytxJ, S1141, aroA, S1140, S1139, ccpA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2699203..2699221) /Source="Nicolas_upshift_promotors" /id="U2311" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=552 /SigmaFactorBS="tgctttttatttatctgatgggaaagcttattAAAGGATTTt cttacataaCGGAGAATAGTATGTATACagcccagtacacatgtttatgattgaagaa a" /listShort="ytxG, ytxH, ytxJ, S1141, aroA" /listLong="S1140, S1139, ccpA" /label="promotor_-10" upshifts complement(2699212) /Source="Nicolas_upshifts" /id="U2311" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=552 /SigmaFactorBS="tgctttttatttatctgatgggaaagcttattAAAGGATTTt cttacataaCGGAGAATAGTATGTATACagcccagtacacatgtttatgattgaagaa a" /listShort="ytxG, ytxH, ytxJ, S1141, aroA" /listLong="S1140, S1139, ccpA" /label="upshifts" promotor_-35 complement(2699232..2699240) /Source="Nicolas_upshift_promotors" /id="U2311" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=552 /SigmaFactorBS="tgctttttatttatctgatgggaaagcttattAAAGGATTTt cttacataaCGGAGAATAGTATGTATACagcccagtacacatgtttatgattgaagaa a" /listShort="ytxG, ytxH, ytxJ, S1141, aroA" /listLong="S1140, S1139, ccpA" /label="promotor_-35" CDS complement(2699292..2700590) /gene="murC" /locus_tag="BSU_29790" /old_locus_tag="BSU29790" /EC_number="6.3.2.8" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10565540, 12682299, 12781748; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetyl muramate-alanine ligase" /protein_id="NP_390857.1" /db_xref="EnsemblGenomes-Gn:BSU29790" /db_xref="EnsemblGenomes-Tr:CAB14957" /db_xref="GOA:P40778" /db_xref="InterPro:IPR000713" /db_xref="InterPro:IPR004101" /db_xref="InterPro:IPR005758" /db_xref="InterPro:IPR013221" /db_xref="InterPro:IPR036565" /db_xref="InterPro:IPR036615" /db_xref="SubtiList:BG10973" /db_xref="UniProtKB/Swiss-Prot:P40778" /translation="MTVYHFVGIKGTGMSPLAQILHDNGYTVQGSDIEKFIFTQTALE KRNITILPFSAENIKPGMTVIAGNAFPDTHPEIEKAMSEGIPVIRYHKFLGDYMKKFT SVAVTGAHGKTSTTGLLAHVIQNAKPTSFLIGDGTGQGNENSEYFVFEACEYRRHFLS YQPDYAIMTNIDFDHPDYFSSIDDVFDAFQEMALQVNKGIIACGDDEHLPKIHANVPV VYYGTGEENDFQARNIVKSTEGTTFDVFVRNTFYDTFYIPAYGHHNVLNSLAVIALCH YEEIDSSIIKHALKSFGGVKRRFNEKQLGDQVLIDDYAHHPTEIKVTIEAARQKYPDR EIVAVFQPHTFTRTQQFLDEFAESLSGADCVYLCDIFGSARENAGKLTIGDLQGKIHN AKLIEEDDTSVLKAHDKAVLIFMGAGDIQKYMRAYENVMA*" /label="murC CDS" gene complement(2699292..2700590) /gene="murC" /locus_tag="BSU_29790" /old_locus_tag="BSU29790" /label="murC gene" downshifts complement(2699301) /Source="Nicolas_upshifts" /id="D1536" /incds=0 /nref=29 /ntot=180 /MaxReadThrough="5.23049" /MaxDrop="5.42617" /score="15.3729968" /energy="-7.5" /TU="U2313,U2314" /idTUdmin="U2312" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2700615..2700634) /Source="Nicolas_upshift_promotors" /id="U2312" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1225 /SigmaFactorBS="agggaggcttttcagccgccGCGGTCGCAAattgaaatgagc GTCATATACTGGGGAACAGAtagacgtttgttggaggtacaattatgactgtttatca t" /listShort="murC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2700616) /Source="Nicolas_upshifts" /id="U2312" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1225 /SigmaFactorBS="agggaggcttttcagccgccGCGGTCGCAAattgaaatgagc GTCATATACTGGGGAACAGAtagacgtttgttggaggtacaattatgactgtttatca t" /listShort="murC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2700618..2700814) /Source="Nicolas_S_feature" /locus_tag="new_3049503_3049699_c" /HighExp="Cold, G150, G135, dia15, G180, H2O2, C30, Oxctl, Paraq, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="SigA" /TUlongPSig="0.938" /label="S1142" promotor_-35 complement(2700647..2700656) /Source="Nicolas_upshift_promotors" /id="U2312" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1225 /SigmaFactorBS="agggaggcttttcagccgccGCGGTCGCAAattgaaatgagc GTCATATACTGGGGAACAGAtagacgtttgttggaggtacaattatgactgtttatca t" /listShort="murC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2700797..2700816) /Source="Nicolas_upshift_promotors" /id="U2313" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.755244755244755" /psig=1 /xcortree=2585 /SigmaFactorBS="tgctgatcacagcaagtgatttaataaacgaataatatggGT TCATTttcacaccaaaCATGGTATGATAGTGTTTAGagcatttaacagctatgccgct t" /listShort="S1142, murC, ytxG, ytxH, ytxJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2700814) /Source="Nicolas_upshifts" /id="U2313" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.755244755244755" /psig=1 /xcortree=2585 /SigmaFactorBS="tgctgatcacagcaagtgatttaataaacgaataatatggGT TCATTttcacaccaaaCATGGTATGATAGTGTTTAGagcatttaacagctatgccgct t" /listShort="S1142, murC, ytxG, ytxH, ytxJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2700828..2700834) /Source="Nicolas_upshift_promotors" /id="U2313" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.755244755244755" /psig=1 /xcortree=2585 /SigmaFactorBS="tgctgatcacagcaagtgatttaataaacgaataatatggGT TCATTttcacaccaaaCATGGTATGATAGTGTTTAGagcatttaacagctatgccgct t" /listShort="S1142, murC, ytxG, ytxH, ytxJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2700840..2703698) /gene="sftA" /locus_tag="BSU_29805" /old_locus_tag="BSU29805" /function="8.1: DNA replication, recombination, and repair" /experiment="publication(s) with functional evidences, PMID:3129532, 11134515, 11208805, 19788545, 28110333" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3129532, 11134515, 11208805, 19788545, 28110333; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="DNA translocase" /protein_id="NP_390859.2" /db_xref="EnsemblGenomes-Gn:BSU29805" /db_xref="EnsemblGenomes-Tr:CAB14959" /db_xref="GOA:C0SP86" /db_xref="InterPro:IPR002543" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR018541" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13906" /db_xref="UniProtKB/Swiss-Prot:C0SP86" /translation="MSWLHKFFDLFLGESEEDAERETKPAQIPQQQEVHHPEGQLKRL EDPKIYYEYPKGKFRFPVVPDGYKNHDLRRRRTPSDEPKSAPRPSAAPYRERPRNEEE QHTYQAAEPAKKPFKPTNIPSPVYGFNQKPSVKKDVPKKPSETLNEPDKSVKEKVTLL SEEIERERGYPASDTQAHSKIESPFFPDTQFEKQPSGVLNRKDTEHDEALAKRPAEPS GNKVPFESGVQQPEKEEPFFPAEQAEEQTPPEMLTDTAAEGLSDSEVGREEPATAEEE QREQQPEKFEEPVFSAELDEEQTAPESQTEAVSEDEKAKEPSDSPVYNHHENAAEGAE SPFVQEEQMDIRQEEPLFTDHEYSSEALAQAETVAKESEEPSESIINNHYDTLGEAQE TKIDVQPDSHTELEKTEHMEQGSKSSTATLENRQEIRADKPREASEEPKKRPGVQEKR TEQSASSQKGPSVPFNVMMLKRDTHKQQKAEERRGSYVFPNVALLDVPPAQVQDDTAW IEEQRQLLDLTLKNFNVRANVVHVTQGPSVTRFEVHPEPGVKVNKITNLSDDIKLSLS AKDIRIEAPIPGKNTIGIEVPNRTSKVVDLRQMIRSSAFRTSKSPLTAALGLDISGNP VVIDLKKMPHGLIAGATGSGKSVCINTILVSLLYKADPSEVKVLLIDPKMVELAPYNK IPHLVSPVITDAKAATAALKWVVEEMERRYELFAHSGVRDIDRFNQLTAEHQMGEKLP YLVVIIDELADLMMVAPNDVEESIARIAQKARACGIHLLVATQRPSVDVITGLIKANI PTRIAFSVSSQVDSRTIIDIAGAEKLLGKGDMLFLENGSGKPVRLQGNFVSDREIDRV VSHVRSQMPPTYLFEQEELVRQGSALKEEDELFYEACEFVVEQNSASTSSLQRRFRIG YNRAARLIDMMEAEGMISEAKGSKPREVLITASDLINE*" /label="sftA CDS" gene complement(2700840..2703698) /gene="sftA" /locus_tag="BSU_29805" /old_locus_tag="BSU29805" /label="sftA gene" promotor_-10 complement(2703732..2703751) /Source="Nicolas_upshift_promotors" /id="U2314" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2568 /SigmaFactorBS="tttagcggctttgtttctgctgatagcttaaTCTTTtctggg ccgaccagcAGTGGTATACTAAAAACCGTcccagaaaactataagggagttagagata a" /listShort="ytpS, S1142, murC, ytxG, ytxH, ytxJ" /listLong="S1141, aroA" /label="promotor_-10" upshifts complement(2703742) /Source="Nicolas_upshifts" /id="U2314" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2568 /SigmaFactorBS="tttagcggctttgtttctgctgatagcttaaTCTTTtctggg ccgaccagcAGTGGTATACTAAAAACCGTcccagaaaactataagggagttagagata a" /listShort="ytpS, S1142, murC, ytxG, ytxH, ytxJ" /listLong="S1141, aroA" /label="upshifts" promotor_-35 complement(2703767..2703771) /Source="Nicolas_upshift_promotors" /id="U2314" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=2568 /SigmaFactorBS="tttagcggctttgtttctgctgatagcttaaTCTTTtctggg ccgaccagcAGTGGTATACTAAAAACCGTcccagaaaactataagggagttagagata a" /listShort="ytpS, S1142, murC, ytxG, ytxH, ytxJ" /listLong="S1141, aroA" /label="promotor_-35" downshifts complement(2703841) /Source="Nicolas_upshifts" /id="D1537" /incds=0 /nref=186 /ntot=249 /MaxReadThrough="4.47299" /MaxDrop="6.35097" /score="9.62039509" /energy="-14.5" /TU="U2315" /idTUdmin="U2315" /TUdmin="-1553" /isTUend="FALSE" /label="downshifts" CDS complement(2703858..2704463) /gene="ytpR" /locus_tag="BSU_29820" /old_locus_tag="BSU29820" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 21949854, 27435445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative tRNA binding enzyme" /protein_id="NP_390860.1" /db_xref="EnsemblGenomes-Gn:BSU29820" /db_xref="EnsemblGenomes-Tr:CAB14960" /db_xref="GOA:O34943" /db_xref="InterPro:IPR002547" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR027855" /db_xref="InterPro:IPR033714" /db_xref="InterPro:IPR037154" /db_xref="SubtiList:BG13905" /db_xref="UniProtKB/Swiss-Prot:O34943" /translation="MNAFYNKEGVGDTLLISLQDVTREQLGYEKHGDVVKIFNNETKE TTGFNIFNASSYLTIDENGPVALSETFVQDVNEILNRNGVEETLVVDLSPKFVVGYVE SKEKHPNADKLSVCKVNVGEETLQIVCGAPNVDQGQKVVVAKVGAVMPSGLVIKDAEL RGVPSSGMICSAKELDLPDAPAEKGILVLEGDYEAGDAFQF*" /label="ytpR CDS" gene complement(2703858..2704463) /gene="ytpR" /locus_tag="BSU_29820" /old_locus_tag="BSU29820" /label="ytpR gene" CDS complement(2704479..2705288) /gene="ytpQ" /locus_tag="BSU_29830" /old_locus_tag="BSU29830" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12719520, 21949854" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (iron homeostasis)" /protein_id="NP_390861.1" /db_xref="EnsemblGenomes-Gn:BSU29830" /db_xref="EnsemblGenomes-Tr:CAB14961" /db_xref="InterPro:IPR010838" /db_xref="SubtiList:BG13904" /db_xref="UniProtKB/Swiss-Prot:O34496" /translation="MKMTSRKLSDILKQRLQHENRSFLFDREKDTLRVEDQTTKKGIT LDLPPIIAKWELKKDEAIDEIVYYVSEAMTAMEGKAQEMTGKETRIYPVIRSTSFPDK SSEDIPLIYDDHTAETRIYYALDLGKTYRLIDQRMLEKENWTKERIRETAAFNLRSLP TVVKEDTVAGNYFYFFRANDGYDASRILNEAILNEYKQHAEGELAISVPHQDVLILAD IRNESGYDILGQMSMSFFAGGTVPITALSFLYNEGKLEPVFILAKSRPKKD*" /label="ytpQ CDS" gene complement(2704479..2705288) /gene="ytpQ" /locus_tag="BSU_29830" /old_locus_tag="BSU29830" /label="ytpQ gene" CDS complement(2705303..2705626) /gene="ytpP" /locus_tag="BSU_29840" /old_locus_tag="BSU29840" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12719520, 15937154, 21949854; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative thiol-disulfide oxidoreductase with thioredoxin domain" /protein_id="NP_390862.1" /db_xref="EnsemblGenomes-Gn:BSU29840" /db_xref="EnsemblGenomes-Tr:CAB14962" /db_xref="GOA:O34357" /db_xref="InterPro:IPR005746" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG13903" /db_xref="UniProtKB/Swiss-Prot:O34357" /translation="MKKIESTQELEKAVKDDWSVFMFSADWCPDCRFVEPFLPELEAN FPEFTYYYVDRDKFIDTCAEWEIYGIPSFVVFNEGKEVNRFVSKDRKTKEEIEQFLTD SLAKA*" /label="ytpP CDS" gene complement(2705303..2705626) /gene="ytpP" /locus_tag="BSU_29840" /old_locus_tag="BSU29840" /label="ytpP gene" S_feature complement(2705627..2705765) /Source="Nicolas_S_feature" /locus_tag="new_3054512_3054650_c" /HighExp="G180, G150, Paraq, Oxctl, H2O2, Diami, C90, dia15, G135, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.32150299999999998" /TUshortSig="SigA" /TUshortPSig="0.938" /TUlongSig="NA" /TUlongPSig="NA" /label="S1143" CDS complement(2705665..2705781) /locus_tag="BSU_29845" /old_locus_tag="BSU29845" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009513998.1" /translation="MQIKYDNDNGKANLTYSFVAYKWFCLKQFGMIQMDEYR*" /label="hypothetical protein CDS" gene complement(2705665..2705781) /locus_tag="BSU_29845" /old_locus_tag="BSU29845" /label="gene" promotor_-10 complement(2705752..2705771) /Source="Nicolas_upshift_promotors" /id="U2315" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.515484515484515" /psig="0.938061938061938" /xcortree=2564 /SigmaFactorBS="atttcaccctcatgtacacgatgttaaacgaaacgagcTtga taatgcaaataaAATATGATAATGATAATGGGaaagccaatcttacatattcattcgt t" /listShort="S1143, ytpP, ytpQ, ytpR, ytpS" /listLong="S1142, murC, ytxG, ytxH, ytxJ" /label="promotor_-10" upshifts complement(2705765) /Source="Nicolas_upshifts" /id="U2315" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.515484515484515" /psig="0.938061938061938" /xcortree=2564 /SigmaFactorBS="atttcaccctcatgtacacgatgttaaacgaaacgagcTtga taatgcaaataaAATATGATAATGATAATGGGaaagccaatcttacatattcattcgt t" /listShort="S1143, ytpP, ytpQ, ytpR, ytpS" /listLong="S1142, murC, ytxG, ytxH, ytxJ" /label="upshifts" promotor_-35 2705773..2705780 /Source="Nicolas_upshift_promotors" /id="U2316" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.925074925074925" /psig="0.98101898101898" /xcortree=2351 /SigmaFactorBS="aagattggctttcccattatcattatcatatttTATTTGCAt tatcaagctcgttTCGTTTAACATCGTGTACATgagggtgaaatttacagatggatat a" /listShort="ytoQ, S1144" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2705795..2705814 /Source="Nicolas_upshift_promotors" /id="U2316" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.925074925074925" /psig="0.98101898101898" /xcortree=2351 /SigmaFactorBS="aagattggctttcccattatcattatcatatttTATTTGCAt tatcaagctcgttTCGTTTAACATCGTGTACATgagggtgaaatttacagatggatat a" /listShort="ytoQ, S1144" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2705800 /Source="Nicolas_upshifts" /id="U2316" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.925074925074925" /psig="0.98101898101898" /xcortree=2351 /SigmaFactorBS="aagattggctttcccattatcattatcatatttTATTTGCAt tatcaagctcgttTCGTTTAACATCGTGTACATgagggtgaaatttacagatggatat a" /listShort="ytoQ, S1144" /GFF_Attribute="listLong" /label="upshifts" CDS 2705861..2706307 /gene="ytoQ" /locus_tag="BSU_29850" /old_locus_tag="BSU29850" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme with sugar binding fold" /protein_id="NP_390863.1" /db_xref="EnsemblGenomes-Gn:BSU29850" /db_xref="EnsemblGenomes-Tr:CAB14963" /db_xref="InterPro:IPR019884" /db_xref="SubtiList:BG13899" /db_xref="UniProtKB/Swiss-Prot:O34305" /translation="MEFIVYLAGEIHSNWREEIKEKTKSLKLPITFVGPMENHDRSDN IGEEIMGVQPNAVLKDDKASDINNFRTAVLMNKADFVIALFGEKYKQWNTAMDASYAI AKGKPLIIIRPESLHHPLKELSNKANITVETVNQAIKALSYLFETE*" /label="ytoQ CDS" gene 2705861..2706307 /gene="ytoQ" /locus_tag="BSU_29850" /old_locus_tag="BSU29850" /label="ytoQ gene" S_feature 2706308..2707036 /Source="Nicolas_S_feature" /locus_tag="new_3055193_3055921" /HighExp="H2O2, dia15, C30, C90, Diami, S1, M0t45, Salt, Paraq, Lbexp" /AntisenseName="ytoP" /AntisenseCor="0.35418735783791" /AntisenseRegPval="-8.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.981" /TUlongSig="NA" /TUlongPSig="NA" /label="S1144" CDS complement(2706362..2707435) /gene="ytoP" /locus_tag="BSU_29860" /old_locus_tag="BSU29860" /EC_number="3.4.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8535515; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative modified amino acid aminopeptidase" /protein_id="NP_390864.1" /db_xref="EnsemblGenomes-Gn:BSU29860" /db_xref="EnsemblGenomes-Tr:CAB14964" /db_xref="GOA:O34924" /db_xref="InterPro:IPR008007" /db_xref="InterPro:IPR023367" /db_xref="SubtiList:BG13898" /db_xref="UniProtKB/Swiss-Prot:O34924" /translation="MNQETKALFQTLTQLPGAPGNEHQVRAFMKQELAKYADDIVQDR LGSVFGVRRGAEDAPRIMVAGHMDEVGFMVTSITDNGLLRFQTLGGWWSQVLLAQRVE IQTDNGPVPGVISSIPPHLLTDAQRNRPMDIKNMMIDIGADDKEDAIKIGIRPGQQIV PVCPFTTMANEKKILSKAWDNRYGCGLSIELLKELHGKELPNTLYAGATVQEEVGLRG AQTASHMIKPDLFFALDASPANDMSGDKNEFGQLGKGFLLRILDRTTVMHRGMREFVL DMAETHDIPYQYFVSGGGTDAGKVHISNSGVPSAVIGICSRYIHTNATIIHIDDYAAA KEMLIKLVTACDKQTVDAIKENM*" /label="ytoP CDS" gene complement(2706362..2707435) /gene="ytoP" /locus_tag="BSU_29860" /old_locus_tag="BSU29860" /label="ytoP gene" downshifts complement(2706381) /Source="Nicolas_upshifts" /id="D1538" /incds=0 /nref=140 /ntot=248 /MaxReadThrough="1.89952" /MaxDrop="4.55096" /score="14.9571314" /energy="-14.4" /TU="NA" /idTUdmin="U2317" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2707457..2707476) /Source="Nicolas_upshift_promotors" /id="U2317" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.701298701298701" /psig="0.998001998001998" /xcortree=2339 /SigmaFactorBS="ctgatcgagcagattgggtcagagTGCTTGGAaaacttcatt gttTCTAATAAAATAAAAGGACTacatagaaatgaggggaaaacatgaatcaagaaac g" /listShort="ytoP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2707461) /Source="Nicolas_upshifts" /id="U2317" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.701298701298701" /psig="0.998001998001998" /xcortree=2339 /SigmaFactorBS="ctgatcgagcagattgggtcagagTGCTTGGAaaacttcatt gttTCTAATAAAATAAAAGGACTacatagaaatgaggggaaaacatgaatcaagaaac g" /listShort="ytoP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2707490..2707497) /Source="Nicolas_upshift_promotors" /id="U2317" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.701298701298701" /psig="0.998001998001998" /xcortree=2339 /SigmaFactorBS="ctgatcgagcagattgggtcagagTGCTTGGAaaacttcatt gttTCTAATAAAATAAAAGGACTacatagaaatgaggggaaaacatgaatcaagaaac g" /listShort="ytoP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2707532..2707535 /Source="Nicolas_upshift_promotors" /id="U2318" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.922077922077922" /psig=1 /xcortree=3184 /SigmaFactorBS="gcactctgacccaatctgctcgatcagccgcgtattgCTTAa caggatttggctgTTTCTGTATAATGAAAAGTAcgatcaaccaggaggtgctttattt t" /listShort="ytzB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2707550..2707569 /Source="Nicolas_upshift_promotors" /id="U2318" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.922077922077922" /psig=1 /xcortree=3184 /SigmaFactorBS="gcactctgacccaatctgctcgatcagccgcgtattgCTTAa caggatttggctgTTTCTGTATAATGAAAAGTAcgatcaaccaggaggtgctttattt t" /listShort="ytzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2707555 /Source="Nicolas_upshifts" /id="U2318" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.922077922077922" /psig=1 /xcortree=3184 /SigmaFactorBS="gcactctgacccaatctgctcgatcagccgcgtattgCTTAa caggatttggctgTTTCTGTATAATGAAAAGTAcgatcaaccaggaggtgctttattt t" /listShort="ytzB" /GFF_Attribute="listLong" /label="upshifts" CDS 2707594..2707911 /gene="ytzB" /locus_tag="BSU_29870" /old_locus_tag="BSU29870" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390865.1" /db_xref="EnsemblGenomes-Gn:BSU29870" /db_xref="EnsemblGenomes-Tr:CAB14965" /db_xref="InterPro:IPR025711" /db_xref="SubtiList:BG13936" /db_xref="UniProtKB/Swiss-Prot:O32065" /translation="MKLRHLLLGAGLGICTAVVVRQYVMKPYISSEKALRIVKSAFKQ RGPIDGSWIYTQPEPYNINGETVQVYKTGITRSAFGELEQYEVMVDAKTGEIVDVIDT IAS*" /label="ytzB CDS" gene 2707594..2707911 /gene="ytzB" /locus_tag="BSU_29870" /old_locus_tag="BSU29870" /label="ytzB gene" downshifts 2707911 /Source="Nicolas_upshifts" /id="D1539" /incds=0 /nref=250 /ntot=259 /MaxReadThrough="1.29231" /MaxDrop="7.83082" /score="44.9062865" /energy="-17" /TU="NA" /idTUdmin="U2318" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2707964..2709664) /gene="maeC" /locus_tag="BSU_29880" /old_locus_tag="BSU29880" /EC_number="1.1.1.38" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:16788182, 20933603, 22740702, 23136871, 24325460" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16788182, 20933603, 22740702, 23136871, 24325460; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NAD-dependent malic enzyme (conversion of malateinto pyruvate)" /protein_id="NP_390866.1" /db_xref="EnsemblGenomes-Gn:BSU29880" /db_xref="EnsemblGenomes-Tr:CAB14966" /db_xref="GOA:O34389" /db_xref="InterPro:IPR001891" /db_xref="InterPro:IPR012301" /db_xref="InterPro:IPR012302" /db_xref="InterPro:IPR015884" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR037062" /db_xref="SubtiList:BG12614" /db_xref="UniProtKB/Swiss-Prot:O34389" /translation="MKQFRVTNEGDIQTTLRGLEVLSVPFLNKGVAFTEEERKELGLK GFLPPKVLTIDDQAKRAYEQYSAQPDDLSKNVYLTALHDRNETLFYRLLNDHLGEMLP IVYTPTVGTAIQRYSHEYRKPRGLYLSIDDPDGMKEAFKQYKDQSDTIDLIVATDAEG ILGIGDWGVGGIAISIGKLAVYTAAAGIDPSRVLAVVLDAGTNQESLLNDPLYVGNQH SRVRGERYDQFIDDYVALARETFPNALLHWEDFGAKNARSILKRYKDKVCTFNDDIQG TGAVSLAAVLSCAKASKVPLRDHRVVIFGAGTAGIGIAEQLREALVREGLSEEESYKR FWCIDRNGLLTDDMDQLLDFQKPYARSADEVKDYQRNGDGGGIDLLEVVRQAKPTILI GTSTVSGAFTEEIVKEMASHVKRPAILPMSNPTTLSEAKPEDLIEWTEGRALITTGSP FPPVEYNGVTYHIGQANNALVFPGLGLGTIVTKSKLITDGMFEACARAIAGMVNVGVP GAPMLPKVEDLRTVSATVAVEVAKTAMKEGVATEEPEDIIQAVQDAMWYPVYKPIRAI *" /label="maeC CDS" gene complement(2707964..2709664) /gene="maeC" /locus_tag="BSU_29880" /old_locus_tag="BSU29880" /label="maeC gene" downshifts complement(2707983) /Source="Nicolas_upshifts" /id="D1540" /incds=0 /nref=77 /ntot=255 /MaxReadThrough="2.4872" /MaxDrop="4.99085" /score="17.675308" /energy="-15.3" /TU="NA" /idTUdmin="U2319" /TUdmin="-18" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2709696..2709714) /Source="Nicolas_upshift_promotors" /id="U2319" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=724 /SigmaFactorBS="aagcgaatgaagcgatagcatatttttaTGTTTACcctgcat gttttccGGCTAATAATGCAAACCTAgtactattatgctcagaaaggaagaggcaggg t" /listShort="malS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2709703) /Source="Nicolas_upshifts" /id="U2319" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=724 /SigmaFactorBS="aagcgaatgaagcgatagcatatttttaTGTTTACcctgcat gttttccGGCTAATAATGCAAACCTAgtactattatgctcagaaaggaagaggcaggg t" /listShort="malS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2709729..2709735) /Source="Nicolas_upshift_promotors" /id="U2319" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=724 /SigmaFactorBS="aagcgaatgaagcgatagcatatttttaTGTTTACcctgcat gttttccGGCTAATAATGCAAACCTAgtactattatgctcagaaaggaagaggcaggg t" /listShort="malS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2709746..2710516) /gene="ytnP" /locus_tag="BSU_29890" /old_locus_tag="BSU29890" /EC_number="3.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22101040, 24268182; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative quorum-quenching lactonase" /protein_id="NP_390867.1" /db_xref="EnsemblGenomes-Gn:BSU29890" /db_xref="EnsemblGenomes-Tr:CAB14967" /db_xref="GOA:O34760" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG13895" /db_xref="UniProtKB/Swiss-Prot:O34760" /translation="MFGVVPKPLWSKKYPVNEKNQIELRTDPILIQKDGLNIIIDAGI GYGKLTDKQKRNYGVTQESNVKPSLAALGLTVADIDVIAMTHLHFDHACGLTEYEGER LVSVFPNAVIYTSAVEWDEMRHPNIRSKNTYWKENWEAVAGQVKTFEDTLTITEGITM HHTGGHSDGHSVLICEDAGETAVHMADLMPTHAHRNPLWVLAYDDYPMTSIPQKQKWQ AFAAEKDAWFIFYHDAEYRALQWEEDGSIKKSVKRMKR*" /label="ytnP CDS" gene complement(2709746..2710516) /gene="ytnP" /locus_tag="BSU_29890" /old_locus_tag="BSU29890" /label="ytnP gene" S_feature complement(2710517..2710605) /Source="Nicolas_S_feature" /locus_tag="new_3059402_3059490_c" /HighExp="HiOs, M40t90, T0.30H, T1.30H, T3.0H, T1.0H, Sw, T2.30H, T3.30H, Gly" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1145" promotor_-10 complement(2710603..2710622) /Source="Nicolas_upshift_promotors" /id="U2320" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.497502497502497" /psig="0.997002997002997" /xcortree=3207 /SigmaFactorBS="gtaaagacagactctgacaggagTCTGTtttttttatgggcc gTTTGCTACCATGATGATAGGggggggtgaaaatggaaacaatgaaaattggaaacat c" /listShort="S1145, ytnP, malS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2710605) /Source="Nicolas_upshifts" /id="U2320" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.497502497502497" /psig="0.997002997002997" /xcortree=3207 /SigmaFactorBS="gtaaagacagactctgacaggagTCTGTtttttttatgggcc gTTTGCTACCATGATGATAGGggggggtgaaaatggaaacaatgaaaattggaaacat c" /listShort="S1145, ytnP, malS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2710638..2710642) /Source="Nicolas_upshift_promotors" /id="U2320" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.497502497502497" /psig="0.997002997002997" /xcortree=3207 /SigmaFactorBS="gtaaagacagactctgacaggagTCTGTtttttttatgggcc gTTTGCTACCATGATGATAGGggggggtgaaaatggaaacaatgaaaattggaaacat c" /listShort="S1145, ytnP, malS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2710662..2711303) /gene="trmB" /locus_tag="BSU_29900" /old_locus_tag="BSU29900" /EC_number="2.1.1.33" /function="16.6: Maintain" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15789416, 16600901, 17150909, 19934251" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15789416, 16600901, 17150909, 19934251; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA (guanine-N(7)-)-methyltransferase" /protein_id="NP_390868.1" /db_xref="EnsemblGenomes-Gn:BSU29900" /db_xref="EnsemblGenomes-Tr:CAB14968" /db_xref="GOA:O34522" /db_xref="InterPro:IPR003358" /db_xref="InterPro:IPR029063" /db_xref="PDB:2FCA" /db_xref="SubtiList:BG13890" /db_xref="UniProtKB/Swiss-Prot:O34522" /translation="MRMRHKPWADDFLAENADIAISNPADYKGKWNTVFGNDNPIHIE VGTGKGQFISGMAKQNPDINYIGIELFKSVIVTAVQKVKDSEAQNVKLLNIDADTLTD VFEPGEVKRVYLNFSDPWPKKRHEKRRLTYSHFLKKYEEVMGKGGSIHFKTDNRGLFE YSLKSFSEYGLLLTYVSLDLHNSNLEGNIMTEYEEKFSALGQPIYRAEVEWRT*" /label="trmB CDS" gene complement(2710662..2711303) /gene="trmB" /locus_tag="BSU_29900" /old_locus_tag="BSU29900" /label="trmB gene" downshifts complement(2710672) /Source="Nicolas_upshifts" /id="D1541" /incds=0 /nref=46 /ntot=131 /MaxReadThrough="3.31031" /MaxDrop="5.64644" /score="29.2137061" /energy="-10.1" /TU="NA" /idTUdmin="U2321" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" downshifts complement(2710737) /Source="Nicolas_upshifts" /id="D1542" /incds=1 /nref=39 /ntot=202 /MaxReadThrough="6.31908" /MaxDrop="3.64275" /score="29.2137061" /energy="-10.1" /TU="U2321,U2323" /idTUdmin="U2323" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2711329..2711348) /Source="Nicolas_upshift_promotors" /id="U2321" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.916083916083916" /psig="0.999000999001" /xcortree=2613 /SigmaFactorBS="ggccttaagagagatacactggaaaaacgaGCTTGcgggtct ttttaattCATGGTATGTTGTTAGTCGAaataatagatagaggtgtcaatcatatgag a" /listShort="trmB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2711338) /Source="Nicolas_upshifts" /id="U2321" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.916083916083916" /psig="0.999000999001" /xcortree=2613 /SigmaFactorBS="ggccttaagagagatacactggaaaaacgaGCTTGcgggtct ttttaattCATGGTATGTTGTTAGTCGAaataatagatagaggtgtcaatcatatgag a" /listShort="trmB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2711340..2711788) /Source="Nicolas_S_feature" /locus_tag="new_3060225_3060673_c" /HighExp="C30, Cold, G135, G180, B60, Paraq, G150, Oxctl, H2O2, LBGstat" /AntisenseName="ytzH" /AntisenseCor="-0.51149457663808795" /AntisenseRegPval="-18.600000000000001" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigD, SigA" /TUlongPSig="1, 0.992" /label="S1146" promotor_-35 complement(2711364..2711368) /Source="Nicolas_upshift_promotors" /id="U2321" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.916083916083916" /psig="0.999000999001" /xcortree=2613 /SigmaFactorBS="ggccttaagagagatacactggaaaaacgaGCTTGcgggtct ttttaattCATGGTATGTTGTTAGTCGAaataatagatagaggtgtcaatcatatgag a" /listShort="trmB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2711447..2711453 /Source="Nicolas_upshift_promotors" /id="U2322" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=942 /SigmaFactorBS="agggtcccgtctgctggaacactcctttcccaTGTATAAaaa cgctctgttttGAACAATTTAACccgtatgatactgaagggatgtgtaccgttatggg t" /listShort="ytzH, S1147" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2711468..2711479 /Source="Nicolas_upshift_promotors" /id="U2322" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=942 /SigmaFactorBS="agggtcccgtctgctggaacactcctttcccaTGTATAAaaa cgctctgttttGAACAATTTAACccgtatgatactgaagggatgtgtaccgttatggg t" /listShort="ytzH, S1147" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2711475 /Source="Nicolas_upshifts" /id="U2322" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=942 /SigmaFactorBS="agggtcccgtctgctggaacactcctttcccaTGTATAAaaa cgctctgttttGAACAATTTAACccgtatgatactgaagggatgtgtaccgttatggg t" /listShort="ytzH, S1147" /GFF_Attribute="listLong" /label="upshifts" CDS 2711510..2711788 /gene="ytzH" /locus_tag="BSU_29910" /old_locus_tag="BSU29910" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390869.1" /db_xref="EnsemblGenomes-Gn:BSU29910" /db_xref="EnsemblGenomes-Tr:CAB14969" /db_xref="InterPro:IPR025547" /db_xref="SubtiList:BG13942" /db_xref="UniProtKB/Swiss-Prot:O32066" /translation="MGLHYEHQVHLLKDILTDHQLDCCGTVAEYEQLERVIKSLMANT ELDSNFKNVLEDVYRYSQSGISSKSIDSHIQEHQNSLSQWVEQMDSYS*" /label="ytzH CDS" gene 2711510..2711788 /gene="ytzH" /locus_tag="BSU_29910" /old_locus_tag="BSU29910" /label="ytzH gene" S_feature 2711789..2711959 /Source="Nicolas_S_feature" /locus_tag="new_3060674_3060844" /HighExp="S5, S7, S8, S6, S4, BT, C30, nit, ferm, G/S" /AntisenseName="ytmP" /AntisenseCor="-0.32108027439793901" /AntisenseRegPval="-7.1" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1147" CDS complement(2711789..2712403) /gene="ytmP" /locus_tag="BSU_29920" /old_locus_tag="BSU29920" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9026440, 11545674; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative kinase/phosphotransferase" /protein_id="NP_390870.2" /db_xref="EnsemblGenomes-Gn:BSU29920" /db_xref="EnsemblGenomes-Tr:CAB14970" /db_xref="GOA:C0SPC1" /db_xref="InterPro:IPR002575" /db_xref="InterPro:IPR011009" /db_xref="SubtiList:BG13889" /db_xref="UniProtKB/Swiss-Prot:C0SPC1" /translation="MENGDVITAQHWMTGRELKPKDMSGRPVAELLRKIHTSKALLDM LKRLGKEPLNPGALLSQLKQAVFAVQQSSPLIQEGIKYLEEHLHEVHFGEKVVCHCDV NHNNWLLSEDNQLYLIDWDGAMIADPAMDLGPLLYHYVEKPAWESWLSMYGIELTESL RLRMAWYVLSETITFIAWHKAKGNDKEFHDAMEELHILMKRIVD*" /label="ytmP CDS" gene complement(2711789..2712403) /gene="ytmP" /locus_tag="BSU_29920" /old_locus_tag="BSU29920" /label="ytmP gene" downshifts 2711937 /Source="Nicolas_upshifts" /id="D1543" /incds=1 /nref=4 /ntot=35 /MaxReadThrough="2.54837" /MaxDrop="3.82368" /score="-4.89809956" /energy="-11.3" /TU="NA" /idTUdmin="U2322" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2712404..2712739) /Source="Nicolas_S_feature" /locus_tag="new_3061289_3061624_c" /HighExp="T1.30H, M9-stat, T2.30H, T3.0H, UNK1, B60, T2.0H, T3.30H, T1.0H, GM-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="SigD, SigA" /TUlongPSig="1, 0.992" /label="S1148" promotor_-10 complement(2712731..2712750) /Source="Nicolas_upshift_promotors" /id="U2323" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.855144855144855" /psig="0.999000999001" /xcortree=2288 /SigmaFactorBS="atatttagcatcagatcttaagagtttTGCTTGACgaagttt gtgctatAGCGCTAAAATTTAAAGGACggctattgattagcatatgagactctcaata g" /listShort="S1148, ytmP, S1146, trmB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2712739) /Source="Nicolas_upshifts" /id="U2323" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.855144855144855" /psig="0.999000999001" /xcortree=2288 /SigmaFactorBS="atatttagcatcagatcttaagagtttTGCTTGACgaagttt gtgctatAGCGCTAAAATTTAAAGGACggctattgattagcatatgagactctcaata g" /listShort="S1148, ytmP, S1146, trmB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2712765..2712772) /Source="Nicolas_upshift_promotors" /id="U2323" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.855144855144855" /psig="0.999000999001" /xcortree=2288 /SigmaFactorBS="atatttagcatcagatcttaagagtttTGCTTGACgaagttt gtgctatAGCGCTAAAATTTAAAGGACggctattgattagcatatgagactctcaata g" /listShort="S1148, ytmP, S1146, trmB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2712766..2714922) /gene="amyX" /locus_tag="BSU_29930" /old_locus_tag="BSU29930" /EC_number="3.2.1.41" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9453151, 16582490, 19465663, 23973973" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9453151, 16582490, 19465663, 23973973; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pullulanase" /protein_id="NP_390871.2" /db_xref="EnsemblGenomes-Gn:BSU29930" /db_xref="EnsemblGenomes-Tr:CAB14971" /db_xref="GOA:C0SPA0" /db_xref="InterPro:IPR004193" /db_xref="InterPro:IPR006047" /db_xref="InterPro:IPR011840" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR014756" /db_xref="InterPro:IPR017853" /db_xref="PDB:2E8Y" /db_xref="PDB:2E8Z" /db_xref="PDB:2E9B" /db_xref="SubtiList:BG12566" /db_xref="UniProtKB/Swiss-Prot:C0SPA0" /translation="MVSIRRSFEAYVDDMNIITVLIPAEQKEIMTPPFRLETEITDFP LAVREEYSLEAKYKYVCVSDHPVTFGKIHCVRASSGHKTDLQIGAVIRTAAFDDEFYY DGELGAVYTADHTVFKVWAPAATSAAVKLSHPNKSGRTFQMTRLEKGVYAVTVTGDLH GYEYLFCICNNSEWMETVDQYAKAVTVNGEKGVVLRPDQMKWTAPLKPFSHPVDAVIY ETHLRDFSIHENSGMINKGKYLALTETDTQTANGSSSGLAYVKELGVTHVELLPVNDF AGVDEEKPLDAYNWGYNPLHFFAPEGSYASNPHDPQTRKTELKQMINTLHQHGLRVIL DVVFNHVYKRENSPFEKTVPGYFFRHDECGMPSNGTGVGNDIASERRMARKFIADCVV YWLEEYNVDGFRFDLLGILDIDTVLYMKEKATKAKPGILLFGEGWDLATPLPHEQKAA LANAPRMPGIGFFNDMFRDAVKGNTFHLKATGFALGNGESAQAVMHGIAGSSGWKALA PIVPEPSQSINYVESHDNHTFWDKMSFALPQENDSRKRSRQRLAAAIILLAQGVPFIH SGQEFFRTKQGVENSYQSSDSINQLDWDRRETFKEDVHYIRRLISLRKAHPAFRLRSA ADIQRHLECLTLKEHLIAYRLYDLDEVDEWKDIIVIHHASPDSVEWRLPNDIPYRLLC DPSGFQEDPTEIKKTVAVNGIGTVILYLASDLKSFA*" /label="amyX CDS" gene complement(2712766..2714922) /gene="amyX" /locus_tag="BSU_29930" /old_locus_tag="BSU29930" /label="amyX gene" Polymorphism join(2714463,2714465) /Source="geneious" /ID="SNP_BsDelta6_3063349_3063349" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change /CDS_Position=459 /Change="A -> G" /Codon_Change="GTT -> GTC" /Coverage=168 /locus_tag="BSU_29930" /Protein_Effect="None" /Reference_Frequency="1.2%" /Reference_Nucleotides="A" /Variant_Nucleotides="G" /Variant_P_Value=0 /Variant_Raw_Frequency=165 /comment="silent" /modified_by="User" / /label="Polymorphism_Delta6" CDS complement(2714948..2715877) /gene="ytlR" /locus_tag="BSU_29940" /old_locus_tag="BSU29940" /EC_number="2.7.1.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phospholipid kinase" /protein_id="NP_390872.1" /db_xref="EnsemblGenomes-Gn:BSU29940" /db_xref="EnsemblGenomes-Tr:CAB14972" /db_xref="GOA:O34799" /db_xref="InterPro:IPR001206" /db_xref="InterPro:IPR005218" /db_xref="InterPro:IPR016064" /db_xref="InterPro:IPR017438" /db_xref="SubtiList:BG13880" /db_xref="UniProtKB/Swiss-Prot:O34799" /translation="MSHWFFIINPTAGHRNGLRVWKSIQKELIKRKVEHRSFLTEHPG HAEVLARQISTIQEYKLKRLIVIGGDGTMHEVVNGLKDVDDIELSFVPAGAYNDFSRG FSIKKIDLIQEIKKVKRPLTRTFHLGSVNFLQDKSQILYFMNHIGIGFDAYVNKKAME FPLRRVFLFLRLRFLVYPLSHLHASATFKPFTLACTTEDETREFHDVWFAVVSNHPFY GGGMKAAPLANPREKTFDIVIVENQPFLKKYWLLCLMAFGKHTKMDGVTMFKAKDITF YTKDKIPFHADGEIMGTTPFRLASSPSPLRIKT*" /label="ytlR CDS" gene complement(2714948..2715877) /gene="ytlR" /locus_tag="BSU_29940" /old_locus_tag="BSU29940" /label="ytlR gene" CDS complement(2715926..2716840) /gene="ytlQ" /locus_tag="BSU_29950" /old_locus_tag="BSU29950" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_390873.1" /db_xref="EnsemblGenomes-Gn:BSU29950" /db_xref="EnsemblGenomes-Tr:CAB14973" /db_xref="InterPro:IPR012397" /db_xref="SubtiList:BG13879" /db_xref="UniProtKB/Swiss-Prot:O34471" /translation="MAQIIKIHDYISRYELDPYHYINQFVRLKKERWLSLVEAAERQH EERQASAEEPEPVQKRKKFSLKRRKEEIKADIQEERHQWFEDEEDIHVRLPKSRVALA SFYKRHLYDFQLKWASSTLSEISQLSNQVKQDRILRYLTQQLPDSYFIMYKPVLKIQQ AAVELSIVIISPLEIYCVSFLEAEEDSVYIGSKNRFWDKKTASQTASVLNPGLSLFRT DSVVSKIVKEKQAEIPVRKLLLSRTSYIDYPEPPYGLEIADKRSAEEWIERQKKNTAP IKHHQVKAAKALLSYCMSDSYRRQEWLE*" /label="ytlQ CDS" gene complement(2715926..2716840) /gene="ytlQ" /locus_tag="BSU_29950" /old_locus_tag="BSU29950" /label="ytlQ gene" promotor_-10 complement(2716603..2716621) /Source="Nicolas_upshift_promotors" /id="U2324" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2820 /SigmaFactorBS="tgcagaaacgaaaaaaattttcattgaaaaGAAGAAAagaag agataaaaGCCGATATACAAGAAGAGAgacaccaatggtttgaggacgaagaagatat t" /listShort="ytlR, amyX" /listLong="S1148, ytmP, S1146, trmB" /label="promotor_-10" upshifts complement(2716611) /Source="Nicolas_upshifts" /id="U2324" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2820 /SigmaFactorBS="tgcagaaacgaaaaaaattttcattgaaaaGAAGAAAagaag agataaaaGCCGATATACAAGAAGAGAgacaccaatggtttgaggacgaagaagatat t" /listShort="ytlR, amyX" /listLong="S1148, ytmP, S1146, trmB" /label="upshifts" promotor_-35 complement(2716635..2716641) /Source="Nicolas_upshift_promotors" /id="U2324" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2820 /SigmaFactorBS="tgcagaaacgaaaaaaattttcattgaaaaGAAGAAAagaag agataaaaGCCGATATACAAGAAGAGAgacaccaatggtttgaggacgaagaagatat t" /listShort="ytlR, amyX" /listLong="S1148, ytmP, S1146, trmB" /label="promotor_-35" CDS complement(2716866..2717417) /gene="ytlP" /locus_tag="BSU_29960" /old_locus_tag="BSU29960" /EC_number="3.1.4.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17012785; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA 2',3'-cyclic phosphodiesterase" /protein_id="NP_390874.1" /db_xref="EnsemblGenomes-Gn:BSU29960" /db_xref="EnsemblGenomes-Tr:CAB14974" /db_xref="GOA:O34570" /db_xref="InterPro:IPR004175" /db_xref="InterPro:IPR009097" /db_xref="SubtiList:BG13878" /db_xref="UniProtKB/Swiss-Prot:O34570" /translation="MPDIRPHYFIGVPIPEGIANPIYQAAKNEPILTFQKWVHPLDYH ITLIFLGAADETQIKKLEGSLAEIASEIDPFSIKFGKIDVFGDRRKPRVLHLEPKKNK TLDRLREHTKQAVLQAGFQVEKRPYHPHMTLARKWTGEDGFPAHVPFESGEVSMMAER FSLFQIHLNQSPKYEEIFKFQLS*" /label="ytlP CDS" gene complement(2716866..2717417) /gene="ytlP" /locus_tag="BSU_29960" /old_locus_tag="BSU29960" /label="ytlP gene" misc_feature 2717280..2717299 /Source="Nicolas_upshift_promotors" /id="U2325" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.962037962037962" /psig="0.996003996003996" /xcortree=2127 /SigmaFactorBS="tagcgaaccttcaagcttctttatttgtgtctcatccgccgc tccgagaaaaattaaCGTGATATGATAGTCAAGCGggtgcacccatttttgaaacgtc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2717283 /Source="Nicolas_upshifts" /id="U2325" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.962037962037962" /psig="0.996003996003996" /xcortree=2127 /SigmaFactorBS="tagcgaaccttcaagcttctttatttgtgtctcatccgccgc tccgagaaaaattaaCGTGATATGATAGTCAAGCGggtgcacccatttttgaaacgtc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2717440..2717459) /Source="Nicolas_upshift_promotors" /id="U2326" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.423576423576424" /psig="0.992007992007992" /xcortree=2211 /SigmaFactorBS="cgtttgtgcgagagtgttttcatacactgttcctCTATccgc acagcctctttATTGATAAAATAATAGCTGTcaaagaagggagtgtcagacggatgcc a" /listShort="ytlP, ytlQ, ytlR, amyX" /listLong="S1148, ytmP, S1146, trmB" /label="promotor_-10" upshifts complement(2717452) /Source="Nicolas_upshifts" /id="U2326" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.423576423576424" /psig="0.992007992007992" /xcortree=2211 /SigmaFactorBS="cgtttgtgcgagagtgttttcatacactgttcctCTATccgc acagcctctttATTGATAAAATAATAGCTGTcaaagaagggagtgtcagacggatgcc a" /listShort="ytlP, ytlQ, ytlR, amyX" /listLong="S1148, ytmP, S1146, trmB" /label="upshifts" promotor_-35 complement(2717475..2717478) /Source="Nicolas_upshift_promotors" /id="U2326" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.423576423576424" /psig="0.992007992007992" /xcortree=2211 /SigmaFactorBS="cgtttgtgcgagagtgttttcatacactgttcctCTATccgc acagcctctttATTGATAAAATAATAGCTGTcaaagaagggagtgtcagacggatgcc a" /listShort="ytlP, ytlQ, ytlR, amyX" /listLong="S1148, ytmP, S1146, trmB" /label="promotor_-35" promotor_-35 2717500..2717507 /Source="Nicolas_upshift_promotors" /id="U2327" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig="0.999000999001" /xcortree=1889 /SigmaFactorBS="ggctgtgcggatagaggaacagtgtatgaaaacacTCTCGCA CaaacgtttatTATGTTAGGATATTATATGAcacttgttttattcagaaaggaatgac a" /listShort="ytkP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2717518..2717537 /Source="Nicolas_upshift_promotors" /id="U2327" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig="0.999000999001" /xcortree=1889 /SigmaFactorBS="ggctgtgcggatagaggaacagtgtatgaaaacacTCTCGCA CaaacgtttatTATGTTAGGATATTATATGAcacttgttttattcagaaaggaatgac a" /listShort="ytkP" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2717521..2717532) /Source="Nicolas_upshift_promotors" /id="U2328" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=895 /SigmaFactorBS="atcagctgtgtttgcaacgattttcaacattgtcattccttt cTGAATAAaacaagtgtcataTAATATCCTAACataataaacgtttgtgcgagagtgt t" /listShort="ytlP, ytlQ, ytlR, amyX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2717525 /Source="Nicolas_upshifts" /id="U2327" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig="0.999000999001" /xcortree=1889 /SigmaFactorBS="ggctgtgcggatagaggaacagtgtatgaaaacacTCTCGCA CaaacgtttatTATGTTAGGATATTATATGAcacttgttttattcagaaaggaatgac a" /listShort="ytkP" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2717535) /Source="Nicolas_upshifts" /id="U2328" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=895 /SigmaFactorBS="atcagctgtgtttgcaacgattttcaacattgtcattccttt cTGAATAAaacaagtgtcataTAATATCCTAACataataaacgtttgtgcgagagtgt t" /listShort="ytlP, ytlQ, ytlR, amyX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2717546..2717552) /Source="Nicolas_upshift_promotors" /id="U2328" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=895 /SigmaFactorBS="atcagctgtgtttgcaacgattttcaacattgtcattccttt cTGAATAAaacaagtgtcataTAATATCCTAACataataaacgtttgtgcgagagtgt t" /listShort="ytlP, ytlQ, ytlR, amyX" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2717566..2718501 /gene="ytkP" /locus_tag="BSU_29970" /old_locus_tag="BSU29970" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12193636, 16267287; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative cysteine synthase-like enzyme" /protein_id="NP_390875.1" /db_xref="EnsemblGenomes-Gn:BSU29970" /db_xref="EnsemblGenomes-Tr:CAB14975" /db_xref="GOA:O34476" /db_xref="InterPro:IPR001216" /db_xref="InterPro:IPR001926" /db_xref="InterPro:IPR005856" /db_xref="InterPro:IPR005859" /db_xref="InterPro:IPR036052" /db_xref="SubtiList:BG13872" /db_xref="UniProtKB/Swiss-Prot:O34476" /translation="MLKIVANTADLIGDTPLVRLNRLQPENAAQVYLKLEFFNPSGSV KDRAAYQMIIEAEQNGLLKPGSVIIEPTSGNTGIGLAMNAAARGYKAILVMPDTMTKE RINLLKAYGAEVVLTPGEERMPGSIKKAKELAEQIPNSYIPMQFDNTANPDAHRKTTA PEIARAIEEIGKPLGAFVASSGTGGTITGTGEALKELFPDITVHVVEPAGSPVLSGGK PGAHKLVGTSPGFIPPILNEDVYDEIIKISDEDAYTTTRRLAAEEGILVGPSSGAACF AAIETAKRLSPDKVVVCMTADTGERYLSTDLWSFI*" /label="ytkP CDS" gene 2717566..2718501 /gene="ytkP" /locus_tag="BSU_29970" /old_locus_tag="BSU29970" /label="ytkP gene" downshifts 2718477 /Source="Nicolas_upshifts" /id="D1544" /incds=0 /nref=74 /ntot=225 /MaxReadThrough="2.5873" /MaxDrop="4.59197" /score="29.2734118" /energy="-18.2" /TU="NA" /idTUdmin="U2327" /TUdmin="-16" /isTUend="TRUE" /label="downshifts" CDS complement(2718535..2719926) /gene="ytjP" /locus_tag="BSU_29980" /old_locus_tag="BSU29980" /EC_number="3.5.-.-" /EC_number="3.4.13.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7528082, 27435445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative promiscuous peptidase/deacylase" /protein_id="NP_390876.1" /db_xref="EnsemblGenomes-Gn:BSU29980" /db_xref="EnsemblGenomes-Tr:CAB14976" /db_xref="GOA:O34944" /db_xref="InterPro:IPR001261" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR010964" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG13867" /db_xref="UniProtKB/Swiss-Prot:O34944" /translation="MNWEVEVIRKKEDLIRDTQEFLRINSVMDETTAGPGKPFGEGVN ASLTSLLELGEKEGFTTKNLDGFAGHIEWGEGDDIIGVLCHVDVVPPGDGWTSDPFSA EIRNGRIYARGAIDDKGPTMAAFYALKIVKDMNLPLSKRVRMIIGTDEESDWRCVEHY FKHEEMPTMGFAPDADFPIINAEKGIIDASLLIPHRPNQAEPKAVLVSFQSGLRLNMV PDAAEAVIEGPKNEEILSSFKDMLRTTDQKGEAAIENGQLILRMYGLSCHAMEPNNGI NAGILLCEFLQQTELDDAGKRFVQVVTDKFSGDTRGKKLDIDCEDEISGELTLNVGTL RYKEGQGGELGINIRYPVTAESKVIRDTFESASEFELGEFKDSKPHHVSADHPLVKTL QKVYEGQLGKKADLISIGGGTYARSLKAGVAFGPLFPGRPDSAHQKDEYIEIDDLLRS TALYAQAIYELAK*" /label="ytjP CDS" gene complement(2718535..2719926) /gene="ytjP" /locus_tag="BSU_29980" /old_locus_tag="BSU29980" /label="ytjP gene" downshifts complement(2718547) /Source="Nicolas_upshifts" /id="D1545" /incds=0 /nref=63 /ntot=240 /MaxReadThrough="3.38616" /MaxDrop="3.73023" /score="23.9099234" /energy="-14.4" /TU="U2330" /idTUdmin="U2330" /TUdmin="-330" /isTUend="FALSE" /label="downshifts" S_feature complement(2719927..2720367) /Source="Nicolas_S_feature" /locus_tag="new_3068812_3069252_c" /HighExp="Etha, Salt, M40t90, Lbtran, T1.30H, M0t90, Lbstat, T1.0H, T0.30H, LBGstat" /AntisenseName="pbuO" /AntisenseCor="-0.324692399913451" /AntisenseRegPval="-7.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1149" promotor_-35 2719953..2719958 /Source="Nicolas_upshift_promotors" /id="U2329" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.403596403596404" /psig="0.994005994005994" /xcortree=2633 /SigmaFactorBS="ataatgatcccctttccgcaagaaatgaCTTGCAaaaaccaa ataaaACGAATAATATTAATGGTGTtttgttaaaacgttcgtaattggaggatactat g" /listShort="pbuO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2719972..2719991 /Source="Nicolas_upshift_promotors" /id="U2329" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.403596403596404" /psig="0.994005994005994" /xcortree=2633 /SigmaFactorBS="ataatgatcccctttccgcaagaaatgaCTTGCAaaaaccaa ataaaACGAATAATATTAATGGTGTtttgttaaaacgttcgtaattggaggatactat g" /listShort="pbuO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2719985 /Source="Nicolas_upshifts" /id="U2329" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.403596403596404" /psig="0.994005994005994" /xcortree=2633 /SigmaFactorBS="ataatgatcccctttccgcaagaaatgaCTTGCAaaaaccaa ataaaACGAATAATATTAATGGTGTtttgttaaaacgttcgtaattggaggatactat g" /listShort="pbuO" /GFF_Attribute="listLong" /label="upshifts" CDS 2720023..2721321 /gene="pbuO" /locus_tag="BSU_29990" /old_locus_tag="BSU29990" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11591660, 12923093, 15849754, 16850406, 19446032, 28583948" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11591660, 12923093, 15849754, 16850406, 19446032, 28583948; Product type t : transporter" /codon_start=1 /transl_table=11 /product="hypoxanthine/guanine permease" /protein_id="NP_390877.1" /db_xref="EnsemblGenomes-Gn:BSU29990" /db_xref="EnsemblGenomes-Tr:CAB14977" /db_xref="GOA:O34978" /db_xref="InterPro:IPR006043" /db_xref="InterPro:IPR026033" /db_xref="SubtiList:BG13864" /db_xref="UniProtKB/Swiss-Prot:O34978" /translation="MFHLKEQQTSIKQEIIAGLTTFFTMVYIVVVNPVILANAGVPFD QVFTATIIASIVGTLWMALAANYPIAIAPGMGLNAYLAFHVVSASDGGITYATAFSAV FTAGVLFIILSLTPLRKQLIEAIPNNLKYGITTGIGLFIAFIGLRQAGIVAADESNLV TLGNLHSPGVILTLVGLLISVVLMVLNVSGALFIGMAATALIAFFTGQLHFSKGFMSL PHLPEGLMISNPFTAFGDVIHHGLYAVVFSFLLVTIFDTTGTMIGVAEQAGLMKNNKL PNVRKALLADSTATTVGAVFGTSPTTAFIESSAGVAAGGRTGLTALTVAVMFAASMFF SPLVSALSGIAAITSPALIIVGSLMMGSVSNMNWKEMDEAFPAFLVILAMPLTSSIST GIALGFISYPIVKAARGKWREIHPLVIVFAILFFIQLFIL*" /label="pbuO CDS" gene 2720023..2721321 /gene="pbuO" /locus_tag="BSU_29990" /old_locus_tag="BSU29990" /label="pbuO gene" promotor_-10 complement(2720344..2720363) /Source="Nicolas_upshift_promotors" /id="U2330" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.5004995004995" /psig="0.997002997002997" /xcortree=3182 /SigmaFactorBS="tgttgtgatcccgtattttaaattgtttggaatcgcttctat aAGTTGTTttcttaaaggcgttAACGATAGAATAATGAAGAGaacccctgctgtaaat a" /listShort="S1149, ytjP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2720367) /Source="Nicolas_upshifts" /id="U2330" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.5004995004995" /psig="0.997002997002997" /xcortree=3182 /SigmaFactorBS="tgttgtgatcccgtattttaaattgtttggaatcgcttctat aAGTTGTTttcttaaaggcgttAACGATAGAATAATGAAGAGaacccctgctgtaaat a" /listShort="S1149, ytjP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2720378..2720384) /Source="Nicolas_upshift_promotors" /id="U2330" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.5004995004995" /psig="0.997002997002997" /xcortree=3182 /SigmaFactorBS="tgttgtgatcccgtattttaaattgtttggaatcgcttctat aAGTTGTTttcttaaaggcgttAACGATAGAATAATGAAGAGaacccctgctgtaaat a" /listShort="S1149, ytjP" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2721308 /Source="Nicolas_upshifts" /id="D1546" /incds=0 /nref=43 /ntot=178 /MaxReadThrough="2.37859" /MaxDrop="5.35341" /score="16.9979166" /energy="-10.2" /TU="NA" /idTUdmin="U2329" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(2721361..2722518) /gene="ythQ" /locus_tag="BSU_30000" /old_locus_tag="BSU30000" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (permease)" /protein_id="NP_390878.1" /db_xref="EnsemblGenomes-Gn:BSU30000" /db_xref="EnsemblGenomes-Tr:CAB14978" /db_xref="GOA:O35029" /db_xref="InterPro:IPR010288" /db_xref="SubtiList:BG13861" /db_xref="UniProtKB/Swiss-Prot:O35029" /translation="MNGRTLFFRRLFDYYKYQFKVLHAVIDWTVALYIVLPAIAFVIY QYIDLMNGRGLLYEWSEVAEWRWLYAVCVLIMFTGSIRTFLMEADKVFLLQKKEIIYQ LKRYALLYSFLATLAKWLLLFFIVLPLISHSVLITFAESTALLCYLFGLHIFFLSLKQ DRIRKPRSISRWIGDTLVRAILFAGSAILIVFTERHLLALFGILFLFFSVIRSLKKTA SFTAFEAEVTEEKKSRLALAGLVMMMSQEAGMPKVKDRMRRKPLLYRNSKRIFKRRTI CTGYKELFFKVMLRNGEYARQMYMLLSAFTVLIFVSPIWLKVIALLVYTGVCRYILTL IFDKVMDAPFLIGTDKESDEYYRARKSCINILHYAFAACCFLAAAVSLLFT*" /label="ythQ CDS" gene complement(2721361..2722518) /gene="ythQ" /locus_tag="BSU_30000" /old_locus_tag="BSU30000" /label="ythQ gene" downshifts complement(2721386) /Source="Nicolas_upshifts" /id="D1547" /incds=0 /nref=1 /ntot=153 /MaxReadThrough="3.07175" /MaxDrop="3.89104" /score="19.8243425" /energy="-11.2" /TU="NA" /idTUdmin="U2332" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 2721634..2721639 /Source="Nicolas_upshift_promotors" /id="U2331" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1395 /SigmaFactorBS="gtgaaagctgacagtagcatgtacatctgcctTGCATActcg ccattcctcaGCATAACTTTAAAAAACAActccttatagcctgtgcagatcgttcgtc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2721654..2721672 /Source="Nicolas_upshift_promotors" /id="U2331" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1395 /SigmaFactorBS="gtgaaagctgacagtagcatgtacatctgcctTGCATActcg ccattcctcaGCATAACTTTAAAAAACAActccttatagcctgtgcagatcgttcgtc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2721662 /Source="Nicolas_upshifts" /id="U2331" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1395 /SigmaFactorBS="gtgaaagctgacagtagcatgtacatctgcctTGCATActcg ccattcctcaGCATAACTTTAAAAAACAActccttatagcctgtgcagatcgttcgtc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2722515..2723225) /gene="ythP" /locus_tag="BSU_30010" /old_locus_tag="BSU30010" /EC_number="3.6.3.-" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_390879.1" /db_xref="EnsemblGenomes-Gn:BSU30010" /db_xref="EnsemblGenomes-Tr:CAB14979" /db_xref="GOA:O34977" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13860" /db_xref="UniProtKB/Swiss-Prot:O34977" /translation="MTNLLEASIEQAGYTSRKKVLTDVFLEVRKGELVGLIGANGAGK STAIKAILGLSEDFKGHIAWNDCSFAYIPEHPSFYEELTLWEHLDLISTLHGIEESEF AHRAQSLLQTFSLDHVKHELPVTFSKGMQQKLMLIQAFLSKPDMYVIDEPFIGLDPIS TKRFVDMLKAEKERGAGILMCTHVLDTAEKICDRFYMIEKGSLFLQGTLKDVQDKTGL EGQSLLDCFYKAVQGDRL*" /label="ythP CDS" gene complement(2722515..2723225) /gene="ythP" /locus_tag="BSU_30010" /old_locus_tag="BSU30010" /label="ythP gene" promotor_-10 complement(2723239..2723254) /Source="Nicolas_upshift_promotors" /id="U2332" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1669 /SigmaFactorBS="ttggattactatgtatttcggctcaatattattatggttaaA GAAACTTTTtttattctattTCGTAGTAAATTTTGGaggtgagtgagttttgacaaat t" /listShort="ythP, ythQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2723256) /Source="Nicolas_upshifts" /id="U2332" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1669 /SigmaFactorBS="ttggattactatgtatttcggctcaatattattatggttaaA GAAACTTTTtttattctattTCGTAGTAAATTTTGGaggtgagtgagttttgacaaat t" /listShort="ythP, ythQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2723266..2723275) /Source="Nicolas_upshift_promotors" /id="U2332" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1669 /SigmaFactorBS="ttggattactatgtatttcggctcaatattattatggttaaA GAAACTTTTtttattctattTCGTAGTAAATTTTGGaggtgagtgagttttgacaaat t" /listShort="ythP, ythQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2723282..2723283 /Source="Nicolas_upshift_promotors" /id="U2333" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.583416583416583" /psig="0.583416583416583" /xcortree=956 /SigmaFactorBS="acctccaaaatttactacgaaatagaataaaaaaagtttctt taaccATaataatattgagccgaaatACATAGTAATCcaacaaggatggctgcccaac g" /listShort="S1150, S1151, ytzE" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2723295..2723400 /Source="Nicolas_S_feature" /locus_tag="new_3072180_3072285" /HighExp="S5, S4, S3, S8, S7, S6, G/S, Pyr, T5.0H, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.583" /TUlongSig="NA" /TUlongPSig="NA" /label="S1150" upshifts 2723295 /Source="Nicolas_upshifts" /id="U2333" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.583416583416583" /psig="0.583416583416583" /xcortree=956 /SigmaFactorBS="acctccaaaatttactacgaaatagaataaaaaaagtttctt taaccATaataatattgagccgaaatACATAGTAATCcaacaaggatggctgcccaac g" /listShort="S1150, S1151, ytzE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2723303..2723313 /Source="Nicolas_upshift_promotors" /id="U2333" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.583416583416583" /psig="0.583416583416583" /xcortree=956 /SigmaFactorBS="acctccaaaatttactacgaaatagaataaaaaaagtttctt taaccATaataatattgagccgaaatACATAGTAATCcaacaaggatggctgcccaac g" /listShort="S1150, S1151, ytzE" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 2723366..2723372 /Source="Nicolas_upshift_promotors" /id="U2334" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.497502497502497" /psig=1 /xcortree=399 /SigmaFactorBS="tggaaaaaattaataggagttatcCCTAGATtcatcactgca ataTCGTGTATAATGAGGGCGAAttattttaacaattacagatgtctgcctttgttgc t" /listShort="S1151, ytzE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2723387..2723406 /Source="Nicolas_upshift_promotors" /id="U2334" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.497502497502497" /psig=1 /xcortree=399 /SigmaFactorBS="tggaaaaaattaataggagttatcCCTAGATtcatcactgca ataTCGTGTATAATGAGGGCGAAttattttaacaattacagatgtctgcctttgttgc t" /listShort="S1151, ytzE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2723402..2723515 /Source="Nicolas_S_feature" /locus_tag="new_3072287_3072400" /HighExp="S4, S5, M0t90, S3, Etha, M9-stat, M40t90, LPhT, Heat, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="1, 0.583" /TUlongSig="NA" /TUlongPSig="NA" /label="S1151" upshifts 2723402 /Source="Nicolas_upshifts" /id="U2334" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.497502497502497" /psig=1 /xcortree=399 /SigmaFactorBS="tggaaaaaattaataggagttatcCCTAGATtcatcactgca ataTCGTGTATAATGAGGGCGAAttattttaacaattacagatgtctgcctttgttgc t" /listShort="S1151, ytzE" /GFF_Attribute="listLong" /label="upshifts" CDS 2723516..2723737 /gene="ytzE" /locus_tag="BSU_30020" /old_locus_tag="BSU30020" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12618461; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (DeoR family)" /protein_id="NP_390880.1" /db_xref="EnsemblGenomes-Gn:BSU30020" /db_xref="EnsemblGenomes-Tr:CAB14980" /db_xref="GOA:O32067" /db_xref="InterPro:IPR001034" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13939" /db_xref="UniProtKB/Swiss-Prot:O32067" /translation="MKPSTNRMLTRIKSVYMFIQEKGLVTTQELVDEFGITPRTIQRD LNVLAYNDLVHSPSRGKWETTRKKVKITS*" /label="ytzE CDS" gene 2723516..2723737 /gene="ytzE" /locus_tag="BSU_30020" /old_locus_tag="BSU30020" /label="ytzE gene" downshifts 2723720 /Source="Nicolas_upshifts" /id="D1548" /incds=0 /nref=166 /ntot=259 /MaxReadThrough="4.38243" /MaxDrop="4.90218" /score="20.9755494" /energy="-13.5" /TU="U2333,U2334" /idTUdmin="U2333" /TUdmin="-54" /isTUend="FALSE" /label="downshifts" downshifts 2723789 /Source="Nicolas_upshifts" /id="D1549" /incds=0 /nref=44 /ntot=172 /MaxReadThrough="-0.189589999999999" /MaxDrop="6.00369" /score="20.9755494" /energy="-13.5" /TU="NA" /idTUdmin="U2334" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" CDS complement(2723858..2724577) /gene="rsuA" /locus_tag="BSU_30035" /old_locus_tag="BSU30035" /EC_number="4.2.1.70" /function="16.6: Maintain" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11953756, 16511038; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="16S rRNA pseudouridylate 516 synthase" /protein_id="NP_390882.2" /db_xref="EnsemblGenomes-Gn:BSU30035" /db_xref="EnsemblGenomes-Tr:CAB14982" /db_xref="GOA:O32068" /db_xref="InterPro:IPR000748" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR006145" /db_xref="InterPro:IPR018496" /db_xref="InterPro:IPR020103" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG13941" /db_xref="UniProtKB/Swiss-Prot:O32068" /translation="MRLDKLLANSGYGSRKEVKAVVKAGAVMIDGKPAKDVKEHVDPD TQEVTVYGEPVDYREFIYLMMNKPQGVLSATEDSRQQTVVDLLTPEEMRFEPFPAGRL DKDTEGFLLLTNDGQLAHRLLSPKKHVPKTYEVHLKSQISREDISDLETGVYIEGGYK TKPAKAEIKTNDSGNTVIYLTITEGKYHQVKQMAKAVGNEVVYLKRLSMGRVSLDPAL APGEYRELTEEELHLLNEPQA*" /label="rsuA CDS" gene complement(2723858..2724577) /gene="rsuA" /locus_tag="BSU_30035" /old_locus_tag="BSU30035" /label="rsuA gene" downshifts complement(2723872) /Source="Nicolas_upshifts" /id="D1550" /incds=0 /nref=1 /ntot=49 /MaxReadThrough="0.79865" /MaxDrop="2.6873" /score="21.6808891" /energy="-13.5" /TU="NA" /idTUdmin="U2335" /TUdmin=154 /isTUend="FALSE" /label="downshifts" downshifts complement(2724643) /Source="Nicolas_upshifts" /id="D1551" /incds=0 /nref=1 /ntot=76 /MaxReadThrough="4.50848" /MaxDrop="2.99899" /score="8.79816042" /energy="-9.5" /TU="U2335" /idTUdmin="U2335" /TUdmin="-617" /isTUend="FALSE" /label="downshifts" CDS complement(2724646..2726280) /gene="murJ" /locus_tag="BSU_30050" /old_locus_tag="BSU30050" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11254558, 15044829, 15849754, 16850406, 19648239, 25918422, 27537185" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11254558, 15044829, 15849754, 16850406, 19648239, 25918422, 27537185; Product type t: transporter" /codon_start=1 /transl_table=11 /product="lipid II flippase" /protein_id="NP_390883.1" /db_xref="EnsemblGenomes-Gn:BSU30050" /db_xref="EnsemblGenomes-Tr:CAB14983" /db_xref="GOA:O34674" /db_xref="InterPro:IPR002797" /db_xref="InterPro:IPR024923" /db_xref="InterPro:IPR029303" /db_xref="SubtiList:BG13856" /db_xref="UniProtKB/Swiss-Prot:O34674" /translation="MSSKLLRGTFVLTLGTYISRILGMVYLIPFSIMVGATGGALFQY GYNQYTLFLNIATMGFPAAVSKFVSKYNSKGDYETSRKMLKAGMSVMLVTGMIAFFIL YLSAPMFAEISLGGKDNNGLTIDHVVYVIRMVSLALLVVPIMSLVRGFFQGHQMMGPT AVSQVVEQIVRIIFLLSATFLILKVFNGGLVIAVGYATFAALIGAFGGLVVLYIYWNK RKGSLLAMMPNTGPTANLSYKKMFFELFSYAAPYVFVGLAIPLYNYIDTNTFNKAMIE AGHQAISQDMLAILTLYVQKLVMIPVSLATAFGLTLIPTITESFTSGNYKLLNQQINQ TMQTILFLIIPAVVGISLLSGPTYTFFYGSESLHPELGANILLWYSPVAILFSLFTVN AAILQGINKQKFAVVSLVIGVVIKLVLNVPLIKLMQADGAILATALGYIASLLYGFIM IKRHAGYSYKILVKRTVLMLVLSAIMGIAVKIVQWVLGFFISYQDGQMQAAIVVVIAA AVGGAVYLYCGYRLGFLQKILGRRLPGFFRKGRHAG*" /label="murJ CDS" gene complement(2724646..2726280) /gene="murJ" /locus_tag="BSU_30050" /old_locus_tag="BSU30050" /label="murJ gene" misc_feature complement(2726312..2726331) /Source="Nicolas_upshift_promotors" /id="U2335" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.631368631368631" /psig="0.999000999001" /xcortree=2597 /SigmaFactorBS="gcggacatgaatgttcacaggattgcttttgtatttattacc gtctaaatgcccagtTGTGGTAAAATAGAAAAGTTgaatcttcgtagaaaatggtgat g" /listShort="ytgP, ytzG" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2726328) /Source="Nicolas_upshifts" /id="U2335" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.631368631368631" /psig="0.999000999001" /xcortree=2597 /SigmaFactorBS="gcggacatgaatgttcacaggattgcttttgtatttattacc gtctaaatgcccagtTGTGGTAAAATAGAAAAGTTgaatcttcgtagaaaatggtgat g" /listShort="ytgP, ytzG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2726398..2726402 /Source="Nicolas_upshift_promotors" /id="U2336" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=2734 /SigmaFactorBS="cattcatgtccgcggcaaaagaCGTTTaaggagcggctttct TTCGCTATAATAGTACTGCGgacgggtgtccgcacacgaaatgaaaagaaagttgatg a" /listShort="ytfP, S1152, S1153, opuD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2726418..2726437 /Source="Nicolas_upshift_promotors" /id="U2336" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=2734 /SigmaFactorBS="cattcatgtccgcggcaaaagaCGTTTaaggagcggctttct TTCGCTATAATAGTACTGCGgacgggtgtccgcacacgaaatgaaaagaaagttgatg a" /listShort="ytfP, S1152, S1153, opuD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2726436 /Source="Nicolas_upshifts" /id="U2336" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.725274725274725" /psig=1 /xcortree=2734 /SigmaFactorBS="cattcatgtccgcggcaaaagaCGTTTaaggagcggctttct TTCGCTATAATAGTACTGCGgacgggtgtccgcacacgaaatgaaaagaaagttgatg a" /listShort="ytfP, S1152, S1153, opuD" /GFF_Attribute="listLong" /label="upshifts" CDS 2726482..2727744 /gene="ytfP" /locus_tag="BSU_30060" /old_locus_tag="BSU30060" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NAD(FAD)-utilizing dehydrogenase" /protein_id="NP_390884.2" /db_xref="EnsemblGenomes-Gn:BSU30060" /db_xref="EnsemblGenomes-Tr:CAB14984" /db_xref="InterPro:IPR004792" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG13850" /db_xref="UniProtKB/Swiss-Prot:Q795R8" /translation="MKQYDVIVIGGGPSGLMAAIAAGEQGAGVLLIDKGNKLGRKLAI SGGGRCNVTNRLPVEEIIKHIPGNGRFLYSAFSEFNNEDIIKFFENLGIQLKEEDHGR MFPVTDKAQSVVDALLNRLKQLRVTIRTNEKIKSVLYEDGQAAGIVTNNGEMIHSQAV IIAVGGKSVPHTGSTGDGYEWAEAAGHTITELFPTEVPVTSGEPFIKQKTLQGLSLRD VAVSVLNKKGKPIITHKMDMLFTHFGLSGPAILRCSQFVVKELKKQPQVPIRIDLYPD INEETLFQKMYKELKEAPKKTIKNVLKPWMQERYLLFLLEKNGISPNVSFSELPKDPF RQFVRDCKQFTVLANGTLSLDKAFVTGGGVSVKEIDPKKMASKKMEGLYFCGEILDIH GYTGGYNITSALVTGRLAGLNAGQYARS*" /label="ytfP CDS" gene 2726482..2727744 /gene="ytfP" /locus_tag="BSU_30060" /old_locus_tag="BSU30060" /label="ytfP gene" S_feature 2727745..2727843 /Source="Nicolas_S_feature" /locus_tag="new_3076630_3076728" /HighExp="LBGstat, Lbstat, M0t90, T2.30H, T1.0H, T0.30H, BC, T2.0H, T1.30H, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1152" promotor_-35 2727817..2727823 /Source="Nicolas_upshift_promotors" /id="U2337" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=147 /SigmaFactorBS="aacattccccgcattcatgttagggtgagactTGTTTTGttt cacctgattgcgGGGTAATTTTAAGAGAGGAatgagctgccatcgtacgaccatacta a" /listShort="S1153, opuD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2727839..2727857 /Source="Nicolas_upshift_promotors" /id="U2337" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=147 /SigmaFactorBS="aacattccccgcattcatgttagggtgagactTGTTTTGttt cacctgattgcgGGGTAATTTTAAGAGAGGAatgagctgccatcgtacgaccatacta a" /listShort="S1153, opuD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2727845..2727932 /Source="Nicolas_S_feature" /locus_tag="new_3076730_3076817" /HighExp="Etha, LBGstat, Salt, M9-stat, Lbstat, LBGtran, Sw, C30, Gly, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigA" /TUshortPSig="0.996, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1153" upshifts 2727845 /Source="Nicolas_upshifts" /id="U2337" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=147 /SigmaFactorBS="aacattccccgcattcatgttagggtgagactTGTTTTGttt cacctgattgcgGGGTAATTTTAAGAGAGGAatgagctgccatcgtacgaccatacta a" /listShort="S1153, opuD" /GFF_Attribute="listLong" /label="upshifts" CDS 2727933..2729471 /gene="opuD" /locus_tag="BSU_30070" /old_locus_tag="BSU30070" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:14996799, 15849754, 16850406, 8752321, 9925583" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14996799, 15849754, 16850406, 8752321, 9925583; Product type t: transporter" /codon_start=1 /transl_table=11 /product="glycine betaine transporter" /protein_id="NP_390885.1" /db_xref="EnsemblGenomes-Gn:BSU30070" /db_xref="EnsemblGenomes-Tr:CAB14985" /db_xref="GOA:P54417" /db_xref="InterPro:IPR000060" /db_xref="InterPro:IPR018093" /db_xref="SubtiList:BG11958" /db_xref="UniProtKB/Swiss-Prot:P54417" /translation="MLKHISSVFWIVIAITAAAVLWGVISPDSLQNVSQSAQAFITDS FGWYYLLVVSLFVGFCLFLIFSPIGKIKLGKPDEKPEFGLLSWFAMLFSAGMGIGLVF YGAAEPISHYAISSPSGETETPQAFRDALRYTFFHWGLHAWAIYAIVALCIAYFQFRK GAPGLISSTLSPILGDKVNGPIGKAIDCIAVFATVVGVSTSLGLGATQINGGLNYLFG IPNAFIVQLVLIIIVTVLFLLSAWSGLGKGIKYLSNTNMVLAGLLMLFMLVVGPTVLI MNSFTDSIGQYIQNIVQMSFRLTPNDPEKREWINSWTIFYWAWWISWSPFVGIFIARV SRGRTIREFLIGVLVTPCILTFLWFSIFGVSAMDLQQKGAFNVAKLSTETMLFGTLDH YPLTMVTSILALILIAVFFITSADSATFVLGMQTSYGSLNPANSVKLSWGIIQSAMAA VLLYSGGLAALQNTAILAALPFSIVILLMIASLYQSLSKERREIKKAEKLDKPRSPRV KKAY*" /label="opuD CDS" gene 2727933..2729471 /gene="opuD" /locus_tag="BSU_30070" /old_locus_tag="BSU30070" /label="opuD gene" downshifts 2729451 /Source="Nicolas_upshifts" /id="D1552" /incds=0 /nref=231 /ntot=263 /MaxReadThrough="2.0688" /MaxDrop="6.06429" /score="27.1497809" /energy="-16.3" /TU="NA" /idTUdmin="U2336" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2729508..2729690) /gene="yteV" /locus_tag="BSU_30080" /old_locus_tag="BSU30080" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 8990290" /codon_start=1 /transl_table=11 /product="conserved sporulation-related protein" /protein_id="NP_390886.1" /db_xref="EnsemblGenomes-Gn:BSU30080" /db_xref="EnsemblGenomes-Tr:CAB14986" /db_xref="GOA:P94496" /db_xref="InterPro:IPR020296" /db_xref="SubtiList:BG12339" /db_xref="UniProtKB/Swiss-Prot:P94496" /translation="MLKVAVFDEEHEKDLQTEINSFLKGISEEQLIDIKYTVSAACDP DGEQLYCFSALILYRK*" /label="yteV CDS" gene complement(2729508..2729690) /gene="yteV" /locus_tag="BSU_30080" /old_locus_tag="BSU30080" /label="yteV gene" downshifts complement(2729527) /Source="Nicolas_upshifts" /id="D1553" /incds=0 /nref=10 /ntot=61 /MaxReadThrough="0.597819999999999" /MaxDrop="4.78152" /score="32.507978" /energy="-16.3" /TU="NA" /idTUdmin="U2338" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2729705..2729723) /Source="Nicolas_upshift_promotors" /id="U2338" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=963 /SigmaFactorBS="gaaagctttttatccggaaacgagataatcatcatttctctA TCATAacgctgttccaaacgGAATAGATTGATAGAGAAAggagagcggataaaatgct g" /listShort="yteV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2729725) /Source="Nicolas_upshifts" /id="U2338" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=963 /SigmaFactorBS="gaaagctttttatccggaaacgagataatcatcatttctctA TCATAacgctgttccaaacgGAATAGATTGATAGAGAAAggagagcggataaaatgct g" /listShort="yteV" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2729739..2729744) /Source="Nicolas_upshift_promotors" /id="U2338" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=963 /SigmaFactorBS="gaaagctttttatccggaaacgagataatcatcatttctctA TCATAacgctgttccaaacgGAATAGATTGATAGAGAAAggagagcggataaaatgct g" /listShort="yteV" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2729758..2730426) /gene="rmgU" /locus_tag="BSU_30090" /old_locus_tag="BSU30090" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 17449691, 23504016; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane enzyme for rhamnogalaturonan degradation" /protein_id="NP_390887.1" /db_xref="EnsemblGenomes-Gn:BSU30090" /db_xref="EnsemblGenomes-Tr:CAB14987" /db_xref="GOA:O34378" /db_xref="InterPro:IPR006938" /db_xref="SubtiList:BG13846" /db_xref="UniProtKB/Swiss-Prot:O34378" /translation="MEHDGSLGRMLRFCEWIMRFAYTNLLWLFFTLLGLGVFGIMPAT AALFAVMRKWIQGQDNVPVLKTFWQEYKGEFFRSNLLGAVLALIGVIIYIDLALIYPS HFLLHILRFAIMIFGFLFVSMLFYVFPLLVHFDWKKRLYVKFSLLLSVAYLQYTLTML ALTVALFFLLAYLPGIVPFFSVSLISYCHMRIVYAVLLKVEQHGGEPQRKSHIRKAFY PETR*" /label="rmgU CDS" gene complement(2729758..2730426) /gene="rmgU" /locus_tag="BSU_30090" /old_locus_tag="BSU30090" /label="rmgU gene" CDS complement(2730448..2731734) /gene="rmgT" /locus_tag="BSU_30100" /old_locus_tag="BSU30100" /EC_number="1.1.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17449691, 23504016; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dehydrogenase of rhamnogalaturonan degradation" /protein_id="NP_390888.1" /db_xref="EnsemblGenomes-Gn:BSU30100" /db_xref="EnsemblGenomes-Tr:CAB14988" /db_xref="GOA:O34371" /db_xref="InterPro:IPR000683" /db_xref="InterPro:IPR004104" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13845" /db_xref="UniProtKB/Swiss-Prot:O34371" /translation="MKNIVFCGLSSRAFSMFIKPLMERFSTHYEITGLLDADPKRFAV CKKKFPELAHVPEFSEDAFDEMMRVSKPDIVIVAGRDDTHVAYIVKSLQWNTDVITEK PMVTTVQDANRVLEAEAKSEGKVTVAFNYRYSPFHRKIKEMILDGKIGRVTSVDLNWY IDTYHGASYFKRWNRSRQFSGGLSVHKSTHHFDLVNWWLGQNPEEVFAYGALNYYGPD SEWNPLPEEDGRFCGTCRVKEKCHYYSRWHPRSSKASIKDDHLEAGDQSSLYTAYRPD ACIFDEEIDIEDTYVAAVKYDGGALLSYSIIFSAPYEGYRLTINGTKGRIESNEFHEP SRIPFAFPEQTIEYYPLFESKQTIQVVKNEGGHGGGDPLLLEDLFLGKDPLRRYDILA GAEAGAYSIAVGEGMWRSVAEKKPIGMKELFQMQNV*" /label="rmgT CDS" gene complement(2730448..2731734) /gene="rmgT" /locus_tag="BSU_30100" /old_locus_tag="BSU30100" /label="rmgT gene" CDS complement(2731746..2732249) /gene="rmgS" /locus_tag="BSU_30110" /old_locus_tag="BSU30110" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17449691, 23504016" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17449691, 23504016; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="lipoprotein required for rhamnogalaturonan transport and degradation" /protein_id="NP_390889.2" /db_xref="EnsemblGenomes-Gn:BSU30110" /db_xref="EnsemblGenomes-Tr:CAB14989" /db_xref="GOA:C0SP80" /db_xref="SubtiList:BG13844" /db_xref="UniProtKB/Swiss-Prot:C0SP80" /translation="MTKRIRTALCVIVSVLFLASCSSRPDGMHVILFSDMQAGVQEKI KKAAEQNAGKVDIFPAFQEKLLTEITAHEGDVFIVPEDMFQAYDDPENFQPLNGLPPE KTSPYTTVNKKTGEKTIYAVQIEKGKKQLNGYSFQLNRDMAAFIPVYAEKTEEALQLI SQLTEAR*" /label="rmgS CDS" gene complement(2731746..2732249) /gene="rmgS" /locus_tag="BSU_30110" /old_locus_tag="BSU30110" /label="rmgS gene" CDS complement(2732246..2733367) /gene="rmgQ" /locus_tag="BSU_30120" /old_locus_tag="BSU30120" /EC_number="3.2.1.172" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15148314, 15906318, 16781735, 16870154, 17449691, 23504016" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15148314, 15906318, 16781735, 16870154, 17449691, 23504016; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="unsaturated rhamnogalacturonyl hydrolase" /protein_id="NP_390890.3" /db_xref="EnsemblGenomes-Gn:BSU30120" /db_xref="EnsemblGenomes-Tr:CAB14990" /db_xref="GOA:O34559" /db_xref="InterPro:IPR008928" /db_xref="InterPro:IPR010905" /db_xref="PDB:1NC5" /db_xref="PDB:2D8L" /db_xref="PDB:2GH4" /db_xref="SubtiList:BG13843" /db_xref="UniProtKB/Swiss-Prot:O34559" /translation="MGSMDQSIAVKSPLTYAEALANTIMNTYTVEELPPANRWHYHQG VFLCGVLRLWEATGEKRYFEYAKAYADLLIDDNGNLLFRRDELDAIQAGLILFPLYEQ TKDERYVKAAKRLRSLYGTLNRTSEGGFWHKDGYPYQMWLDGLYMGGPFALKYANLKQ ETELFDQVVLQESLMRKHTKDAKTGLFYHAWDEAKKMPWANEETGCSPEFWARSIGWY VMSLADMIEELPKKHPNRHVWKNTLQDMIKSICRYQDKETGLWYQIVDKGDRSDNWLE SSGSCLYMYAIAKGINKGYLDRAYETTLLKAYQGLIQHKTETSEDGAFLVKDICVGTS AGFYDYYVSRERSTNDLHGAGAFILAMTELEPLFRSAGK*" /label="rmgQ CDS" gene complement(2732246..2733367) /gene="rmgQ" /locus_tag="BSU_30120" /old_locus_tag="BSU30120" /label="rmgQ gene" CDS complement(2733375..2734340) /gene="rmgP" /locus_tag="BSU_30135" /old_locus_tag="BSU30135" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 17449691, 23504016" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 17449691, 23504016; Product type t: transporter" /codon_start=1 /transl_table=11 /product="permease for unsaturated rhamnogalacturonan" /protein_id="NP_390892.2" /db_xref="EnsemblGenomes-Gn:BSU30135" /db_xref="EnsemblGenomes-Tr:CAB14992" /db_xref="GOA:C0SPB3" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG13841" /db_xref="UniProtKB/Swiss-Prot:C0SPB3" /translation="MKTAEAQAPAVDAVIFKKEKRKRLLIKLIQQKYLYLMILPGCIY FLLFKYVPMWGIVIAFQDYQPFLGILGSEWVGLKHFIRLFTEPTFFLLLKNTLVLFAL NLAIFFPVPILLALLLNEVRIALFKKFVQTLIYIPHFMSWVIVVSLSFVLLTVDGGLI NELIVFFGGEKINFLLNEEWFRPLYILQVIWREAGWSTIIYLAAITAVDPQLYEAAKM DGAGRLRQMWHITLPAIKSVIVVLLILKIGDTLELGFEHVYLLLNATNREVAEIFDTY VYTAGLKQGQFSYSTAVGVFKAAVGLILVMLANRLAKKFGEEGIY*" /label="rmgP CDS" gene complement(2733375..2734340) /gene="rmgP" /locus_tag="BSU_30135" /old_locus_tag="BSU30135" /label="rmgP gene" upshifts complement(2734366) /Source="Nicolas_upshifts" /id="U2339" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.75924075924076" /psig="0.918081918081918" /xcortree=341 /SigmaFactorBS="caggatgtgatcatatgaTTGTAGACggacttttgcctgcTG CGCTACAGTGAATGCAAGaatccgtgaaaggaggctaggaaaaaatgaaaacagcaga a" /listShort="yteP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2734367..2734386) /Source="Nicolas_upshift_promotors" /id="U2339" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.75924075924076" /psig="0.918081918081918" /xcortree=341 /SigmaFactorBS="caggatgtgatcatatgaTTGTAGACggacttttgcctgcTG CGCTACAGTGAATGCAAGaatccgtgaaaggaggctaggaaaaaatgaaaacagcaga a" /listShort="yteP" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2734401..2734408) /Source="Nicolas_upshift_promotors" /id="U2339" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.75924075924076" /psig="0.918081918081918" /xcortree=341 /SigmaFactorBS="caggatgtgatcatatgaTTGTAGACggacttttgcctgcTG CGCTACAGTGAATGCAAGaatccgtgaaaggaggctaggaaaaaatgaaaacagcaga a" /listShort="yteP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2734496..2734503 /Source="Nicolas_upshift_promotors" /id="U2340" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.965034965034965" /psig="0.998001998001998" /xcortree=561 /SigmaFactorBS="cggtccacctgaaaaaaagacaccgatattagaaaatgatTA TTGACAatatctatcaatcttTGGATTAATTGTATTAAGGTgaagtggatgttatgaa a" /listShort="ytdP" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2734516 /Source="Nicolas_upshifts" /id="U2340" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.965034965034965" /psig="0.998001998001998" /xcortree=561 /SigmaFactorBS="cggtccacctgaaaaaaagacaccgatattagaaaatgatTA TTGACAatatctatcaatcttTGGATTAATTGTATTAAGGTgaagtggatgttatgaa a" /listShort="ytdP" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2734519..2734538 /Source="Nicolas_upshift_promotors" /id="U2340" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.965034965034965" /psig="0.998001998001998" /xcortree=561 /SigmaFactorBS="cggtccacctgaaaaaaagacaccgatattagaaaatgatTA TTGACAatatctatcaatcttTGGATTAATTGTATTAAGGTgaagtggatgttatgaa a" /listShort="ytdP" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2734556..2736874 /gene="rmgR" /locus_tag="BSU_30150" /old_locus_tag="BSU30150" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 23504016; Product type r: regulator" /codon_start=1 /transl_table=11 /product="membrane bound transcriptional regulator (controlling rhamnogalacturonan degradation)" /protein_id="NP_390893.1" /db_xref="EnsemblGenomes-Gn:BSU30150" /db_xref="EnsemblGenomes-Tr:CAB14993" /db_xref="GOA:O32071" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR018060" /db_xref="SubtiList:BG13838" /db_xref="UniProtKB/Swiss-Prot:O32071" /translation="MGGFMKRSQYKFYYKLITFFCLLSTIPVILVGLFSYEHSQKTAI SNVSEEKFDTLQQTQQSIEHILKTVDHSLTHYVSSPPLLRTLSEPLHSDQFQIYNQVN QELNYLQSFDTDLSNMTLVSYTKKWYMNNSGLYRLNTDTLHEAASAYTKQKASRSYWT LEENNHLISTKEGTAENCRYNINLIKQLPLNSTNTKGLAAASIPSCSLVKNMPGYSNA NNLFIIDEKGLIILHNNMSDVGESLHNDGFVQKVLAQTANSGQFETVIDRIHYKVTYQ KSDYNAWTYFSLVSLPELKKEAKSIGWITFAVCLILLTLSLLFSWLGSRHFYKPIRVL YESFARHGAIQEKQQPPQNEFELIEQSFKQLKDRNDDLEETMKQQATHLQQYFMVRLM LGKLTDEEVDNRFESLGLKQNWRHLALLVLQIDTLNHTPYEKKDMDLLLFAVNSLIER NIPTDKHLAPAVVDKQQATILINQSGTKEEFMAELNETARMIQEKAEAELQLSVSIGI SQPFDVLTKAKTAYAEGSEALKYRLKAENKSIIFYEDLDQKKTFKTHFPKQLQHELFD AVKAGDKEKADKCLHAILQAIFTQNTNPYQFQIAIARFLNHVIELMHVLGIELFELEE NKMLYDQIFELKTFEDTENWLKNEFIDPMTDKVNARADAQYKNISDNIIHIIHHEFES ELTLDEIARRLHYNPNYLSSIFKKEMGISFSEYVSSYRHHMAKSWLAETDMAVKDIAE KLKYKNSQNFIRSFKKLEGITPGNYRQQKRSM*" /label="rmgR CDS" gene 2734556..2736874 /gene="rmgR" /locus_tag="BSU_30150" /old_locus_tag="BSU30150" /label="rmgR gene" downshifts 2736864 /Source="Nicolas_upshifts" /id="D1554" /incds=0 /nref=8 /ntot=42 /MaxReadThrough="1.43431" /MaxDrop="3.6268" /score="-7.37324741" /energy="-10.2" /TU="NA" /idTUdmin="U2340" /TUdmin=1870 /isTUend="FALSE" /label="downshifts" CDS complement(2736915..2738411) /gene="ytcQ" /locus_tag="BSU_30160" /old_locus_tag="BSU30160" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative ABC transporter (binding lipoprotein)" /protein_id="NP_390894.3" /db_xref="EnsemblGenomes-Gn:BSU30160" /db_xref="EnsemblGenomes-Tr:CAB14994" /db_xref="GOA:Q795R2" /db_xref="SubtiList:BG13836" /db_xref="UniProtKB/Swiss-Prot:Q795R2" /translation="MGNKWRVLLIVLVLALGGVLAGCKGTDQSSAEGKAGPDSKVKLS WMAILYHQQPPKDRAIKEIEKLTNTELDITWVPDAVKEDRLNAALAAGNLPQIVTIQD IKNSSVMNAFRSGMFWEIGDYIKDYPNLNKMNKLINKNVTIDGKLYGIYRERPLSRQG IVIRKDWLDNLNLKTPKTLDELYEVAKAFTEDDPDKDGKDDTFGLADRNDLIYGAFKT IGSYEGMPTDWKESGGKFTPDFMTQEYKDTMNYMKKLRDNGYMNKDFPVTSKTQQQEL FSQGKAGIYIGNMVDAVNLRDHASDKSMKLEIINRIKGPDGKERVWASGGHNGVFAFP KTSVKTEAELKRILAFFDRIAEEDVYSLMTYGIDGVHYNKGEDKTFTRKESQVKDWQT DIQPLSALIAIDKAYLKNTGDPLRTAYEELTEDNEKIIVSNPAESLYSASESERGDEL KKIIDDATYKYMIGDITESQFDKEVEKWESSGGKQIIQEYEEAFKQAK*" /label="ytcQ CDS" gene complement(2736915..2738411) /gene="ytcQ" /locus_tag="BSU_30160" /old_locus_tag="BSU30160" /label="ytcQ gene" downshifts complement(2736917) /Source="Nicolas_upshifts" /id="D1555" /incds=0 /nref=26 /ntot=160 /MaxReadThrough="-0.0485899999999999" /MaxDrop="5.21039" /score="6.31011081" /energy="-11.2" /TU="NA" /idTUdmin="U2341" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(2738436..2739296) /gene="ytcP" /locus_tag="BSU_30170" /old_locus_tag="BSU30170" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (permease)" /protein_id="NP_390895.1" /db_xref="EnsemblGenomes-Gn:BSU30170" /db_xref="EnsemblGenomes-Tr:CAB14995" /db_xref="GOA:P53561" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11788" /db_xref="UniProtKB/Swiss-Prot:P53561" /translation="MKNRLFDMLIYGFLLMFALICVLPFIHVIAASFATVEEVVSKKF ILIPTTFSLDAYRYIFSTDIIYKSLLVSVFVTVIGTAVSMFLSSLMAYGLSRRDLIGR QPLMFLVVFTMLFSGGMIPTFLVVKSLGLLDSYWALILPTAINAFNLIILKNFFQNIP SSLEESAKIDGCNDLGIFFKIVLPLSLPAIATISLFYAVTYWNTYMTAILYLNDSAKW PIQVLLRQIVIVSSGMQGDMSEMGSGSPPPEQTIKMAVIVVATIPVLLVYPFIQKHFA KGALLGSVKG*" /label="ytcP CDS" gene complement(2738436..2739296) /gene="ytcP" /locus_tag="BSU_30170" /old_locus_tag="BSU30170" /label="ytcP gene" promotor_-10 complement(2739372..2739391) /Source="Nicolas_upshift_promotors" /id="U2341" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.72927072927073" /psig="0.998001998001998" /xcortree=353 /SigmaFactorBS="cccggccggggacactgttcaaatgatTATAGACAtggcaat cacagattTGCTACATTTTAGACACGATatcgtcacatgctgagctcggtttccaaaa a" /listShort="ytcP, ytcQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2739381) /Source="Nicolas_upshifts" /id="U2341" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.72927072927073" /psig="0.998001998001998" /xcortree=353 /SigmaFactorBS="cccggccggggacactgttcaaatgatTATAGACAtggcaat cacagattTGCTACATTTTAGACACGATatcgtcacatgctgagctcggtttccaaaa a" /listShort="ytcP, ytcQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2739407..2739414) /Source="Nicolas_upshift_promotors" /id="U2341" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.72927072927073" /psig="0.998001998001998" /xcortree=353 /SigmaFactorBS="cccggccggggacactgttcaaatgatTATAGACAtggcaat cacagattTGCTACATTTTAGACACGATatcgtcacatgctgagctcggtttccaaaa a" /listShort="ytcP, ytcQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2739503..2740264) /gene="ytbQ" /locus_tag="BSU_30180" /old_locus_tag="BSU30180" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NAD-dependent nucleoside-diphosphate-sugar epimerase" /protein_id="NP_390896.2" /db_xref="EnsemblGenomes-Gn:BSU30180" /db_xref="EnsemblGenomes-Tr:CAB14996" /db_xref="GOA:P53560" /db_xref="InterPro:IPR001509" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11787" /db_xref="UniProtKB/Swiss-Prot:P53560" /translation="MKKVLIAGGNGVIGRLLAEGLISDYEVTVLDKDHFDGKASSIQA DAANYEELLKKIPKDTDAILNLLAVKIKYDIMDIAEFEKMTDVFYRASYYLCRAAAEL GIQKLVFASSNHVTDVYEKDGRSLLGREITTSDYPLSKNLYGVLKLTSEQIGHLFYLE NKLSVINLRIGTVVTDEMDTLHEKERTKKTLLSHPDLLSIFKAAIETNIRYGTYYAVS DNPGRPWSIESAVNELGFSPQINTAELLNEEENGA*" /label="ytbQ CDS" gene complement(2739503..2740264) /gene="ytbQ" /locus_tag="BSU_30180" /old_locus_tag="BSU30180" /label="ytbQ gene" downshifts complement(2739532) /Source="Nicolas_upshifts" /id="D1556" /incds=0 /nref=153 /ntot=196 /MaxReadThrough="1.18543" /MaxDrop="5.85654" /score="12.3836957" /energy="-11.1" /TU="NA" /idTUdmin="U2344" /TUdmin="-19" /isTUend="TRUE" /label="downshifts" S_feature complement(2740265..2740340) /Source="Nicolas_S_feature" /locus_tag="new_3089150_3089225_c" /HighExp="LPh, HPh, aero, Gly, HiOs, BMM, GM-0.1, GM 10, GM 15, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1154" CDS complement(2740341..2741528) /gene="bioI" /locus_tag="BSU_30190" /old_locus_tag="BSU30190" /EC_number="1.14.14.46" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11368323, 11472016, 12943422, 20658980, 21435937, 21437340, 28196402" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11368323, 11472016, 12943422, 20658980, 21435937, 21437340, 28196402; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome P450 for pimelic acid formation for biotin biosynthesis" /protein_id="NP_390897.1" /db_xref="EnsemblGenomes-Gn:BSU30190" /db_xref="EnsemblGenomes-Tr:CAB14997" /db_xref="GOA:P53554" /db_xref="InterPro:IPR001128" /db_xref="InterPro:IPR002397" /db_xref="InterPro:IPR017972" /db_xref="InterPro:IPR036396" /db_xref="PDB:3EJB" /db_xref="PDB:3EJD" /db_xref="PDB:3EJE" /db_xref="SubtiList:BG11528" /db_xref="UniProtKB/Swiss-Prot:P53554" /translation="MTIASSTASSEFLKNPYSFYDTLRAVHPIYKGSFLKYPGWYVTG YEETAAILKDARFKVRTPLPESSTKYQDLSHVQNQMMLFQNQPDHRRLRTLASGAFTP RTTESYQPYIIETVHHLLDQVQGKKKMEVISDFAFPLASFVIANIIGVPEEDREQLKE WAASLIQTIDFTRSRKALTEGNIMAVQAMAYFKELIQKRKRHPQQDMISMLLKGREKD KLTEEEAASTCILLAIAGHETTVNLISNSVLCLLQHPEQLLKLRENPDLIGTAVEECL RYESPTQMTARVASEDIDICGVTIRQGEQVYLLLGAANRDPSIFTNPDVFDITRSPNP HLSFGHGHHVCLGSSLARLEAQIAINTLLQRMPSLNLADFEWRYRPLFGFRALEELPV TFE*" /label="bioI CDS" gene complement(2740341..2741528) /gene="bioI" /locus_tag="BSU_30190" /old_locus_tag="BSU30190" /label="bioI gene" CDS complement(2741597..2742604) /gene="bioB" /locus_tag="BSU_30200" /old_locus_tag="BSU30200" /EC_number="2.8.1.6" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2110099, 8763940, 11717296, 12368242" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2110099, 8763940, 11717296, 12368242; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="biotin synthase" /protein_id="NP_390898.1" /db_xref="EnsemblGenomes-Gn:BSU30200" /db_xref="EnsemblGenomes-Tr:CAB14998" /db_xref="GOA:P53557" /db_xref="InterPro:IPR002684" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR010722" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR024177" /db_xref="SubtiList:BG11525" /db_xref="UniProtKB/Swiss-Prot:P53557" /translation="MNQWMELADRVLAGAEVTDEEALSILHCPDEDILLLMHGAFHIR KHFYGKKVKLNMIMNAKSGLCPENCGYCSQSAISKAPIESYRMVNKETLLEGAKRAHD LNIGTYCIVASGRGPSNREVDQVVDAVQEIKETYGLKICACLGLLKPEQAKRLKDAGV DRYNHNLNTSQRNHSNITTSHTYDDRVNTVEIAKESGLSPCSGAIIGMKETKQDVIDI AKSLKALDADSIPVNFLHAIDGTPLEGVNELNPLYCLKVLALFRFINPSKEIRISGGR EVNLRTLQPLGLYAANSIFVGDYLTTAGQEETEDHKMLSDLGFEVESVEEMKASLSAK S*" /label="bioB CDS" gene complement(2741597..2742604) /gene="bioB" /locus_tag="BSU_30200" /old_locus_tag="BSU30200" /label="bioB gene" CDS complement(2742607..2743302) /gene="bioD" /locus_tag="BSU_30210" /old_locus_tag="BSU30210" /EC_number="6.3.3.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2110099, 8763940, 11717296, 12368242, 20565114" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2110099, 8763940, 11717296, 12368242, 20565114; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dethiobiotin synthetase" /protein_id="NP_390899.1" /db_xref="EnsemblGenomes-Gn:BSU30210" /db_xref="EnsemblGenomes-Tr:CAB14999" /db_xref="GOA:P53558" /db_xref="InterPro:IPR004472" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11526" /db_xref="UniProtKB/Swiss-Prot:P53558" /translation="MRGFFVTGTDTEVGKTVISSGLAALLKDNNRHVGVYKPFLSGIS RHHPDSDTSLLKDMSQTSLSHEDITPFAFKAPLAPYVAGKLEGKTVTMEEVLSHWGRI REKHECFIVEGAGGISVPLGEDYLVSHVIKALQLPMIIVARPRLGTINHTFLTVKYAE SMGLPIAGIIINGISDSPDEDEKTNPEMIERLCGVPILGVTPKLANVTKETVLHMVKD HINLSLLMNQVGV*" /label="bioD CDS" gene complement(2742607..2743302) /gene="bioD" /locus_tag="BSU_30210" /old_locus_tag="BSU30210" /label="bioD gene" CDS complement(2743299..2744468) /gene="bioFC" /locus_tag="BSU_30220" /old_locus_tag="BSU30220" /EC_number="2.3.1.-" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8763940, 11322938, 11717296, 12368242, 15056910, 16557306" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8763940, 11322938, 11717296, 12368242, 15056910, 16557306; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="8-amino-7-oxononanoate synthase (pimeloyl-CoA-dependent)" /protein_id="NP_390900.1" /db_xref="EnsemblGenomes-Gn:BSU30220" /db_xref="EnsemblGenomes-Tr:CAB15000" /db_xref="GOA:P53556" /db_xref="InterPro:IPR001917" /db_xref="InterPro:IPR004723" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG11527" /db_xref="UniProtKB/Swiss-Prot:P53556" /translation="MKIDSWLNERLDRMKEAGVHRNLRSMDGAPVPERNIDGENQTVW SSNNYLGLASDRRLIDAAQTALQQFGTGSSGSRLTTGNSVWHEKLEKKIASFKLTEAA LLFSSGYLANVGVLSSLPEKEDVILSDQLNHASMIDGCRLSKADTVVYRHIDMNDLEN KLNETQRYQRRFIVTDGVFSMDGTIAPLDQIISLAKRYHAFVVVDDAHATGVLGDSGQ GTSEYFGVCPDIVIGTLSKAVGAEGGFAAGSAVFIDFLLNHARTFIFQTAIPPASCAA AHEAFNIIEASREKRQLLFSYISMIRTSLKNMGYVVKGDHTPIIPVVIGDAHKTVLFA EKLQGKGIYAPAIRPPTVAPGESRIRITITSDHSMGDIDHLLQTFHSIGKELHII*" /label="bioFC CDS" gene complement(2743299..2744468) /gene="bioFC" /locus_tag="BSU_30220" /old_locus_tag="BSU30220" /label="bioFC gene" promotor_-35 2743335..2743342 /Source="Nicolas_upshift_promotors" /id="U2342" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.996003996003996" /psig="0.997002997002997" /xcortree=2064 /SigmaFactorBS="tcctttccgattgaatgaaaTGTTTGCAgcaaatgatcaata TCACCCATACTGTGGTCAGAcgtgattgtaattcgaatccggctttcacccggcgcaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2743357..2743376 /Source="Nicolas_upshift_promotors" /id="U2342" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.996003996003996" /psig="0.997002997002997" /xcortree=2064 /SigmaFactorBS="tcctttccgattgaatgaaaTGTTTGCAgcaaatgatcaata TCACCCATACTGTGGTCAGAcgtgattgtaattcgaatccggctttcacccggcgcaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2743375 /Source="Nicolas_upshifts" /id="U2342" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.996003996003996" /psig="0.997002997002997" /xcortree=2064 /SigmaFactorBS="tcctttccgattgaatgaaaTGTTTGCAgcaaatgatcaata TCACCCATACTGTGGTCAGAcgtgattgtaattcgaatccggctttcacccggcgcaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2744458..2745804) /gene="bioK" /locus_tag="BSU_30230" /old_locus_tag="BSU30230" /EC_number="2.6.1.105" /function="4.1: Biotin" /experiment="publication(s) with functional evidences, PMID:15880481, 20565114, 21437340" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15880481, 20565114, 21437340; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-lysine-8-amino-7-oxononanoate aminotransferase" /protein_id="NP_390901.1" /db_xref="EnsemblGenomes-Gn:BSU30230" /db_xref="EnsemblGenomes-Tr:CAB15001" /db_xref="GOA:P53555" /db_xref="InterPro:IPR005814" /db_xref="InterPro:IPR005815" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="PDB:3DOD" /db_xref="PDB:3DRD" /db_xref="PDB:3DU4" /db_xref="SubtiList:BG11524" /db_xref="UniProtKB/Swiss-Prot:P53555" /translation="MTHDLIEKSKKHLWLPFTQMKDYDENPLIIESGTGIKVKDINGK EYYDGFSSVWLNVHGHRKKELDDAIKKQLGKIAHSTLLGMTNVPATQLAETLIDISPK KLTRVFYSDSGAEAMEIALKMAFQYWKNIGKPEKQKFIAMKNGYHGDTIGAVSVGSIE LFHHVYGPLMFESYKAPIPYVYRSESGDPDECRDQCLRELAQLLEEHHEEIAALSIES MVQGASGMIVMPEGYLAGVRELCTTYDVLMIVDEVATGFGRTGKMFACEHENVQPDLM AAGKGITGGYLPIAVTFATEDIYKAFYDDYENLKTFFHGHSYTGNQLGCAVALENLAL FESENIVEQVAEKSKKLHFLLQDLHALPHVGDIRQLGFMCGAELVRSKETKEPYPADR RIGYKVSLKMRELGMLTRPLGDVIAFLPPLASTAEELSEMVAIMKQAIHEVTSLED*" /label="bioK CDS" gene complement(2744458..2745804) /gene="bioK" /locus_tag="BSU_30230" /old_locus_tag="BSU30230" /label="bioK gene" promotor_-35 2744874..2744878 /Source="Nicolas_upshift_promotors" /id="U2343" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=1183 /SigmaFactorBS="gccaagctgattgcctgtataggaatggccatggaaaaaggT TTTTaggttttcataatcaTCATAGAATGCCTTATAGAtgtcttcagtggcaaacgta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2744893 /Source="Nicolas_upshifts" /id="U2343" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=1183 /SigmaFactorBS="gccaagctgattgcctgtataggaatggccatggaaaaaggT TTTTaggttttcataatcaTCATAGAATGCCTTATAGAtgtcttcagtggcaaacgta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2744894..2744912 /Source="Nicolas_upshift_promotors" /id="U2343" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.977022977022977" /psig="0.977022977022977" /xcortree=1183 /SigmaFactorBS="gccaagctgattgcctgtataggaatggccatggaaaaaggT TTTTaggttttcataatcaTCATAGAATGCCTTATAGAtgtcttcagtggcaaacgta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2745794..2746570) /gene="bioW" /locus_tag="BSU_30240" /old_locus_tag="BSU30240" /EC_number="6.2.1.14" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8763940, 11368323, 11717296, 21437340, 28196402, 29054876" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8763940, 11368323, 11717296, 21437340, 28196402, 29054876; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="6-carboxyhexanoate-CoA ligase (pimeloyl-CoA synthase)" /protein_id="NP_390902.3" /db_xref="EnsemblGenomes-Gn:BSU30240" /db_xref="EnsemblGenomes-Tr:CAB15002" /db_xref="GOA:P53559" /db_xref="InterPro:IPR005499" /db_xref="PDB:5FLG" /db_xref="PDB:5FLL" /db_xref="PDB:5FM0" /db_xref="PDB:5G1F" /db_xref="SubtiList:BG11529" /db_xref="UniProtKB/Swiss-Prot:P53559" /translation="MQEETFYSVRMRASMNGSHEDGGKHISGGERLIPFHEMKHTVNA LLEKGLSHSRGKPDFMQIQFEEVHESIKTIQPLPVHTNEVSCPEEGQKLARLLLEKEG VSRDVIEKAYEQIPEWSDVRGAVLFDIHTGKRMDQTKEKGVRVSRMDWPDANFEKWAL HSHVPAHSRIKEALALASKVSRHPAVVAELCWSDDPDYITGYVAGKKMGYQRITAMKE YGTEEGCRVFFIDGSNDVNTYIHDLEKQPILIEWEEDHDS*" /label="bioW CDS" gene complement(2745794..2746570) /gene="bioW" /locus_tag="BSU_30240" /old_locus_tag="BSU30240" /label="bioW gene" S_feature complement(2746571..2746663) /Source="Nicolas_S_feature" /locus_tag="new_3095456_3095548_c" /HighExp="T-5.40H, GM 60, LPh, GM 25, HPh, MG 120, M9-exp, BMM, GM 5, MG 150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1155" promotor_-10 complement(2746649..2746668) /Source="Nicolas_upshift_promotors" /id="U2344" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2918 /SigmaFactorBS="tttaaccaactgccataaatcgatcctttcttcTATTGACAg aaacaggagagaaTAATATATTCTAATTGTTAAcctttgaatataattggttaacaat t" /listShort="S1155, bioW, bioK, bioF, bioD, bioB, bioI, S1154, ytbQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2746663) /Source="Nicolas_upshifts" /id="U2344" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2918 /SigmaFactorBS="tttaaccaactgccataaatcgatcctttcttcTATTGACAg aaacaggagagaaTAATATATTCTAATTGTTAAcctttgaatataattggttaacaat t" /listShort="S1155, bioW, bioK, bioF, bioD, bioB, bioI, S1154, ytbQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2746683..2746690) /Source="Nicolas_upshift_promotors" /id="U2344" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2918 /SigmaFactorBS="tttaaccaactgccataaatcgatcctttcttcTATTGACAg aaacaggagagaaTAATATATTCTAATTGTTAAcctttgaatataattggttaacaat t" /listShort="S1155, bioW, bioK, bioF, bioD, bioB, bioI, S1154, ytbQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2746780..2747679) /gene="ytaP" /locus_tag="BSU_30250" /old_locus_tag="BSU30250" /EC_number="3.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_390903.1" /db_xref="EnsemblGenomes-Gn:BSU30250" /db_xref="EnsemblGenomes-Tr:CAB15003" /db_xref="GOA:O34973" /db_xref="InterPro:IPR002471" /db_xref="InterPro:IPR002925" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG11786" /db_xref="UniProtKB/Swiss-Prot:O34973" /translation="MRAERRKQLFRLLGDLPDRRPISVETLRIEEREENIVETLLLDL NGHEKAPAYFVKPKKTEGPCPAVLFQHSHGGQYDRGKSELIEGADYLKTPSFSDELTS LGYGVLAIDHWGFGDRRGKAESEIFKEMLLTGKVMWGMMIYDSLSALDYMQSRSDVQP DRIGTIGMSMGGLMAWWTAALDDRIKVCVDLCSQVDHHVLIKTQNLDRHGFYYYVPSL AKHFSASEIQSLIAPRPHLSLVGVHDRLTPAEGVDKIEKELTAVYAGQGAADCYRVVR SASGHFETAVIRHEAVRFLQKWL*" /label="ytaP CDS" gene complement(2746780..2747679) /gene="ytaP" /locus_tag="BSU_30250" /old_locus_tag="BSU30250" /label="ytaP gene" promotor_-10 complement(2747702..2747720) /Source="Nicolas_upshift_promotors" /id="U2345" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=517 /SigmaFactorBS="ctaaatatttagtaaatgatgtgatttatgttggaaaaatAA AGGGGAAcccagatctgTCTCGTAAATGTGAAGTAAgcgaataaggaagggtgatggg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2747719) /Source="Nicolas_upshifts" /id="U2345" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=517 /SigmaFactorBS="ctaaatatttagtaaatgatgtgatttatgttggaaaaatAA AGGGGAAcccagatctgTCTCGTAAATGTGAAGTAAgcgaataaggaagggtgatggg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2747731..2747739) /Source="Nicolas_upshift_promotors" /id="U2345" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=517 /SigmaFactorBS="ctaaatatttagtaaatgatgtgatttatgttggaaaaatAA AGGGGAAcccagatctgTCTCGTAAATGTGAAGTAAgcgaataaggaagggtgatggg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2747809..2747816 /Source="Nicolas_upshift_promotors" /id="U2346" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=330 /SigmaFactorBS="agtaaatattatggaatatttcgaaaacaatTATTGTAAccg cttacttttataTGATAATATCAATTTATCAAaaacagatgagttaatattttactaa a" /listShort="msmR, msmE, amyD, amyC, melA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2747832..2747851 /Source="Nicolas_upshift_promotors" /id="U2346" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=330 /SigmaFactorBS="agtaaatattatggaatatttcgaaaacaatTATTGTAAccg cttacttttataTGATAATATCAATTTATCAAaaacagatgagttaatattttactaa a" /listShort="msmR, msmE, amyD, amyC, melA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2747838 /Source="Nicolas_upshifts" /id="U2346" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=330 /SigmaFactorBS="agtaaatattatggaatatttcgaaaacaatTATTGTAAccg cttacttttataTGATAATATCAATTTATCAAaaacagatgagttaatattttactaa a" /listShort="msmR, msmE, amyD, amyC, melA" /GFF_Attribute="listLong" /label="upshifts" CDS 2747897..2748931 /gene="msmR" /locus_tag="BSU_30260" /old_locus_tag="BSU30260" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12847288; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (LacI family)" /protein_id="NP_390904.1" /db_xref="EnsemblGenomes-Gn:BSU30260" /db_xref="EnsemblGenomes-Tr:CAB15004" /db_xref="GOA:O34829" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG12626" /db_xref="UniProtKB/Swiss-Prot:O34829" /translation="MVRIKDIALKAKVSSATVSRILNEDESLSVAGETRQRVINIAEE LGYQTVAKRRKSRGQKQRAQPLIGVLSCLSPDQERQDPYFSSIRKGIEKECFEQEIFI TNSIHLGSFQEHIFRELDGVIVIGRVHDEAVKHISGRLEHAVFINHSPDPQAYDSIGI DFESASRQAIDHLFDLGYKRLGYIGGQEKEHTLKDGQSIRRTIEDKRLTAFLESAAPQ PEHVLIGEYSMREGYRLMKKAIDQGHLPEAFFIASDSMAIGALKALQEAGLQVPRDTA IVSFNGIEEAEFASTPLTTVKVYTEEMGRTGVKLLLDRLNGRTLPQHVTLPTTLIVRQ SCGCTAKEVT*" /label="msmR CDS" gene 2747897..2748931 /gene="msmR" /locus_tag="BSU_30260" /old_locus_tag="BSU30260" /label="msmR gene" promotor_-35 2748880..2748887 /Source="Nicolas_upshift_promotors" /id="U2347" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.72027972027972" /psig="0.72027972027972" /xcortree=350 /SigmaFactorBS="tcaacatgtcaccctgcctacAACATTAAtcgtaagacaaag cTGCGGATGTacagcaaaggaggtgacataagcaaagattcatcacgatgataaggag g" /listShort="msmE, amyD, amyC, melA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2748902..2748910 /Source="Nicolas_upshift_promotors" /id="U2347" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.72027972027972" /psig="0.72027972027972" /xcortree=350 /SigmaFactorBS="tcaacatgtcaccctgcctacAACATTAAtcgtaagacaaag cTGCGGATGTacagcaaaggaggtgacataagcaaagattcatcacgatgataaggag g" /listShort="msmE, amyD, amyC, melA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2748919 /Source="Nicolas_upshifts" /id="U2347" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.72027972027972" /psig="0.72027972027972" /xcortree=350 /SigmaFactorBS="tcaacatgtcaccctgcctacAACATTAAtcgtaagacaaag cTGCGGATGTacagcaaaggaggtgacataagcaaagattcatcacgatgataaggag g" /listShort="msmE, amyD, amyC, melA" /GFF_Attribute="listLong" /label="upshifts" CDS 2748965..2750245 /gene="msmE" /locus_tag="BSU_30270" /old_locus_tag="BSU30270" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8449892, 12847288, 16707683, 18954360, 28036052; Product type lp : lipoprotein" /codon_start=1 /transl_table=11 /product="multiple sugar-binding lipoprotein" /protein_id="NP_390905.1" /db_xref="EnsemblGenomes-Gn:BSU30270" /db_xref="EnsemblGenomes-Tr:CAB15005" /db_xref="GOA:O34335" /db_xref="InterPro:IPR006059" /db_xref="PDB:4R6H" /db_xref="SubtiList:BG12625" /db_xref="UniProtKB/Swiss-Prot:O34335" /translation="MKHTFVLFLSLILLVLPGCSAEKSSADTAKKTLTIYSTMSTDSE RDTFRKLAAAFEKEHSDIHVSLHFPGNDYENMMRVRMAANDLPDLFDTHGWGKIRYGE YTADLRDMKWTQDLDPNLNSILKNKSGKVYAYPINQAKDGLAYNRNILDRYGIAPPET MDDFIKALRTIKEKSKGSIVPFWFAGYDKSSFAQYYDQFATPLLITDPAHNEKKQLIN GTFQWSKFTYLSEILKQMQKEKLINIDAVTAKKSQLIELMAQNKIAFTMQGGTLGQDV AQINPNVKVGIIPTPAIHPGDDPIWIGGERYTLAAWKDSPQLKEAKDFIAFMARPANA KQMAEATSLPSGLTNVKADIFYANDYEYYQDVKVEPYFDRLYLPNGMWDVLGTVGQEL AADILAPQDISQKLGREYKRLREQSETQGAENNE*" /label="msmE CDS" gene 2748965..2750245 /gene="msmE" /locus_tag="BSU_30270" /old_locus_tag="BSU30270" /label="msmE gene" CDS 2750238..2751149 /gene="msmF" /locus_tag="BSU_30280" /old_locus_tag="BSU30280" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1537846, 12847288, 15849754, 16707683, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="carbohydrate ABC transporter (permease)" /protein_id="NP_390906.1" /db_xref="EnsemblGenomes-Gn:BSU30280" /db_xref="EnsemblGenomes-Tr:CAB15006" /db_xref="GOA:O34706" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035277" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12565" /db_xref="UniProtKB/Swiss-Prot:O34706" /translation="MSEIARDVHVKQVKPKKQSSLWWMYIPALLSVLVFMIYPFVKGT LITFTNWNGFSQVYQWVGFAQYERLFSDPDTWHILKNTLHYGLGSTFFQNVVGLLYAL LLNQSIKTKAVTRTIVYLPVMISPLIMGYIWYFFFSYDGGALNDLLGVFGISPINALA SPSLNPWIIVMINTYQYVGIAMVVYLAGLQSIPKDYYEAAQMDGAKQGQQFFTITLPL LMPSITINIVINIIGGLKLFDVIIALTAGGPGNASQSMSTFMYDLYFKRQDAGYAATQ GIFMAFVILIISFCALAYFKRKETEMS*" /label="msmF CDS" gene 2750238..2751149 /gene="msmF" /locus_tag="BSU_30280" /old_locus_tag="BSU30280" /label="msmF gene" CDS 2751146..2751976 /gene="msmG" /locus_tag="BSU_30290" /old_locus_tag="BSU30290" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1537846, 15849754, 16707683, 16850406, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="maltose and multiple sugars ABC transporter (permease)" /protein_id="NP_390907.1" /db_xref="EnsemblGenomes-Gn:BSU30290" /db_xref="EnsemblGenomes-Tr:CAB15007" /db_xref="GOA:O34518" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12564" /db_xref="UniProtKB/Swiss-Prot:O34518" /translation="MRAARTKSMRIITLLAAIVACAHFIPFYILLTTSLKAKGDYSSK WIFPADISFHNFSEAWERASLGNSFINTMIITGFSALLLIIFGSLAAYPLARRETKLN KAVFALLISIMIIPPLTSMVPLYRMVVDAGMVNTHAIAIFINTAAYMPLTVFLYSGFI RSTIPKELVEAARIDGAGMLKIFFTIVFPLLKPITATICIISCVFIWNDYQFAIFFLQ DQKVQTLTVAMAGFFGENANNLHLVAAAALMAMLPMVVLFLALQKYFIAGLSSGAVKG *" /label="msmG CDS" gene 2751146..2751976 /gene="msmG" /locus_tag="BSU_30290" /old_locus_tag="BSU30290" /label="msmG gene" promotor_-35 2751949..2751953 /Source="Nicolas_upshift_promotors" /id="U2348" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig="0.997002997002997" /xcortree=2740 /SigmaFactorBS="tttttggcgctgcaaaaatactttattgccggCCTGTcttcc ggagcggtaaAGGGTTAACATTAAAGGGGGaagcaatatgaaaaagattacatttatc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2751969..2751988 /Source="Nicolas_upshift_promotors" /id="U2348" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig="0.997002997002997" /xcortree=2740 /SigmaFactorBS="tttttggcgctgcaaaaatactttattgccggCCTGTcttcc ggagcggtaaAGGGTTAACATTAAAGGGGGaagcaatatgaaaaagattacatttatc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2751977 /Source="Nicolas_upshifts" /id="U2348" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.933066933066933" /psig="0.997002997002997" /xcortree=2740 /SigmaFactorBS="tttttggcgctgcaaaaatactttattgccggCCTGTcttcc ggagcggtaaAGGGTTAACATTAAAGGGGGaagcaatatgaaaaagattacatttatc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 2751996..2753294 /gene="melA" /locus_tag="BSU_30300" /old_locus_tag="BSU30300" /EC_number="3.2.1.22" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12847288; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alpha-D-galactoside galactohydrolase" /protein_id="NP_390908.1" /db_xref="EnsemblGenomes-Gn:BSU30300" /db_xref="EnsemblGenomes-Tr:CAB15008" /db_xref="GOA:O34645" /db_xref="InterPro:IPR001088" /db_xref="InterPro:IPR015955" /db_xref="InterPro:IPR019802" /db_xref="InterPro:IPR022616" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12615" /db_xref="UniProtKB/Swiss-Prot:O34645" /translation="MKKITFIGAGSTIFAKNVLGDCLLTEALNGFEFALYDIDPKRLQ ESQLMLENLRDRYNPSVAINSYDDRKLALQNAGYVINAIQVGGYKPSTVIDFEIPKRY GLRQTIADTVGIGGIFRSLRTIPVLFDIAKDMEEMCPDAWFLNYTNPMATLTGAMLRY TNIKTIGLCHSVQVCTKDLFKALGMEHDGIEERIAGINHMAWLLEVKKDGTDLYPEIK RRAKEKQKTKHHDMVRFELMDKFGYYVTESSEHNAEYHPYFIKRNYPELISELQIPLD EYPRRCVKQIENWEKMRDDIVNNKNLTHERSKEYGSRIIEAMETNEPFTFGGNVLNTG LITNLPSKAVVEVTCVADRKKITPCFAGELPEQLAALNRTNINTQLMTIEAAVTRKKE AVYQAAMLDPHTSAELSMKDIISMCDDLFAAHGDWLPEYK*" /label="melA CDS" gene 2751996..2753294 /gene="melA" /locus_tag="BSU_30300" /old_locus_tag="BSU30300" /label="melA gene" downshifts 2753275 /Source="Nicolas_upshifts" /id="D1557" /incds=0 /nref=12 /ntot=55 /MaxReadThrough="3.99614" /MaxDrop="3.96455" /score="26.0469828" /energy="-11.9" /TU="NA" /idTUdmin="U2346" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2753316..2753627) /gene="ytwF" /locus_tag="BSU_30310" /old_locus_tag="BSU30310" /EC_number="2.8.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10939241, 22730127; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sulfur transferase" /protein_id="NP_390909.2" /db_xref="EnsemblGenomes-Gn:BSU30310" /db_xref="EnsemblGenomes-Tr:CAB15009" /db_xref="GOA:O32072" /db_xref="InterPro:IPR001763" /db_xref="InterPro:IPR036873" /db_xref="SubtiList:BG13932" /db_xref="UniProtKB/Swiss-Prot:O32072" /translation="MEIKEISTAALKEKIEADEELYLIDVREDEEVAEGMIPQAVHIR MGDIPEKMETLDKDKEYVFICRSGMRSMNVCKYLDEQGFKTVNVEGGMMAWEGETKPK N*" /label="ytwF CDS" gene complement(2753316..2753627) /gene="ytwF" /locus_tag="BSU_30310" /old_locus_tag="BSU30310" /label="ytwF gene" downshifts complement(2753327) /Source="Nicolas_upshifts" /id="D1558" /incds=0 /nref=84 /ntot=254 /MaxReadThrough="2.71726" /MaxDrop="5.77228" /score="23.1306393" /energy="-11.9" /TU="NA" /idTUdmin="U2349" /TUdmin="-20" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2753651..2753670) /Source="Nicolas_upshift_promotors" /id="U2349" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.58941058941059" /psig="0.999000999001" /xcortree=1932 /SigmaFactorBS="aaaggggattttttttcatcagtctcaGAATAGCAatcgttc ggctgacTTTGATATACTGAACATGATcactgtgaataggagtgttttctttggaaat a" /listShort="ytwF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2753659) /Source="Nicolas_upshifts" /id="U2349" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.58941058941059" /psig="0.999000999001" /xcortree=1932 /SigmaFactorBS="aaaggggattttttttcatcagtctcaGAATAGCAatcgttc ggctgacTTTGATATACTGAACATGATcactgtgaataggagtgttttctttggaaat a" /listShort="ytwF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2753685..2753692) /Source="Nicolas_upshift_promotors" /id="U2349" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.58941058941059" /psig="0.999000999001" /xcortree=1932 /SigmaFactorBS="aaaggggattttttttcatcagtctcaGAATAGCAatcgttc ggctgacTTTGATATACTGAACATGATcactgtgaataggagtgttttctttggaaat a" /listShort="ytwF" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2753693 /Source="Nicolas_upshifts" /id="D1559" /incds=0 /nref=3 /ntot=17 /MaxReadThrough="0.749090000000001" /MaxDrop="4.59307" /score="20.1681452" /energy="-11.2" /TU="NA" /idTUdmin="U2346" /TUdmin=418 /isTUend="FALSE" /label="downshifts" CDS complement(2753744..2756158) /gene="leuS" /locus_tag="BSU_30320" /old_locus_tag="BSU30320" /EC_number="6.1.1.4" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 1317842" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 1317842; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="leucyl-tRNA synthetase" /protein_id="NP_390910.1" /db_xref="EnsemblGenomes-Gn:BSU30320" /db_xref="EnsemblGenomes-Tr:CAB15010" /db_xref="GOA:P36430" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR002300" /db_xref="InterPro:IPR002302" /db_xref="InterPro:IPR009008" /db_xref="InterPro:IPR009080" /db_xref="InterPro:IPR013155" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR015413" /db_xref="InterPro:IPR025709" /db_xref="SubtiList:BG10676" /db_xref="UniProtKB/Swiss-Prot:P36430" /translation="MSFQHKEIEKKWQTYWLENKTFATLDNNEKQKFYALDMFPYPSG AGLHVGHPEGYTATDILSRMKRMQGYDVLHPMGWDAFGLPAEQYALDTGNDPAVFTKQ NIDNFRRQIQALGFSYDWDREINTTDPEYYKWTQWIFLKLYEKGLAYVDEVPVNWCPA LGTVLANEEVIDGKSERGGHPVERRPMKQWMLKITAYADRLLEDLEELDWPESIKDMQ RNWIGRSEGAHVHFAIDGHDDSFTVFTTRPDTLFGATYTVLAPEHALVENITTAEQKE AVEAYIKEIQSKSDLERTDLAKTKTGVFTGAYAINPVNGEKLPIWIADYVLASYGTGA VMAVPGHDERDFEFAKTFGLPVKEVVKGGNVEEAAYTGDGEHVNSDFLNGLHKQEAIE KVIAWLEETKNGEKKVTYRLRDWLFSRQRYWGEPIPVIHWEDGTSTAVPEEELPLILP KTDEIKPSGTGESPLANIKEWVEVTDPETGKKGRRETNTMPQWAGSCWYFLRYIDPHN PDQLASPEKLEKWLPVDMYIGGAEHAVLHLLYARFWHKFLYDIGVVPTKEPFQKLYNQ GMILGENNEKMSKSKGNVVNPDEIVASHGADTLRLYEMFMGPLDASIAWSESGLDGAR RFLDRVWRLFIEDSGELNGKIVEGAGETLERVYHETVMKVTDHYEGLRFNTGISQLMV FINEAYKATELPKEYMEGFVKLLSPVAPHLAEELWEKLGHSGTIAYEAWPVYDETKLV DDEVEIVVQLNGKVKAKLQVPADATKEQLEQLAQADEKVKEQLEGKTIRKIIAVPGKL VNIVAN*" /label="leuS CDS" gene complement(2753744..2756158) /gene="leuS" /locus_tag="BSU_30320" /old_locus_tag="BSU30320" /label="leuS gene" downshifts complement(2753748) /Source="Nicolas_upshifts" /id="D1560" /incds=0 /nref=115 /ntot=224 /MaxReadThrough="3.2803" /MaxDrop="4.46738" /score="33.3300042" /energy="-11.2" /TU="U2350" /idTUdmin="U2350" /TUdmin="-67" /isTUend="FALSE" /label="downshifts" S_feature complement(2756159..2756254) /Source="Nicolas_S_feature" /locus_tag="new_3105044_3105139_c" /HighExp="G150, G180, G135, LBGexp, HPh, LBGtran, Paraq, Lbexp, H2O2, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.989" /label="S1156" misc_RNA complement(2756268..2756482) /gene="tboL" /locus_tag="BSU_misc_RNA_49" /product="T-box riboswitch specific of leucine tRNA ligase" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 1317842, 9098041, 12165569, 12547201, 27169680; Product type n: RNA" /function="16.3: Control" /label="tboL RNA" gene complement(2756268..2756482) /gene="tboL" /locus_tag="BSU_misc_RNA_49" /label="tboL gene" downshifts complement(2756299) /Source="Nicolas_upshifts" /id="D1561" /incds=0 /nref=8 /ntot=38 /MaxReadThrough="6.86098" /MaxDrop="4.90189" /score="40.6873438" /energy="-16.7" /TU="U2350" /idTUdmin="U2352" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2756494..2756513) /Source="Nicolas_upshift_promotors" /id="U2350" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.444555444555445" /psig=1 /xcortree=2672 /SigmaFactorBS="atctccgcccgttcagggtacattcccattgtatacaaacct GCTTGCacttatgaacagaaTTCTATAAAATACAGTTAGAttacggttgcgataagaa c" /listShort="NA, S1156, leuS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2756515) /Source="Nicolas_upshifts" /id="U2350" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.444555444555445" /psig=1 /xcortree=2672 /SigmaFactorBS="atctccgcccgttcagggtacattcccattgtatacaaacct GCTTGCacttatgaacagaaTTCTATAAAATACAGTTAGAttacggttgcgataagaa c" /listShort="NA, S1156, leuS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2756519..2756524 /Source="Nicolas_upshift_promotors" /id="U2351" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=1009 /SigmaFactorBS="atctaactgtattttatagaattctgTTCATAagtgcaagca ggtttGTATACAATGGGAATGTACcctgaacgggcggagattgaggacaattattcgg g" /listShort="S1157" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(2756528..2756533) /Source="Nicolas_upshift_promotors" /id="U2350" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.444555444555445" /psig=1 /xcortree=2672 /SigmaFactorBS="atctccgcccgttcagggtacattcccattgtatacaaacct GCTTGCacttatgaacagaaTTCTATAAAATACAGTTAGAttacggttgcgataagaa c" /listShort="NA, S1156, leuS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2756540..2756558 /Source="Nicolas_upshift_promotors" /id="U2351" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=1009 /SigmaFactorBS="atctaactgtattttatagaattctgTTCATAagtgcaagca ggtttGTATACAATGGGAATGTACcctgaacgggcggagattgaggacaattattcgg g" /listShort="S1157" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2756553..2756993 /Source="Nicolas_S_feature" /locus_tag="new_3105438_3105878" /HighExp="S4, S5, S3, S8, S7, S6, T5.0H, LoTm, C30, M9-stat" /AntisenseName="ytvB" /AntisenseCor="0.57398798861917499" /AntisenseRegPval="-24.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.978" /TUlongSig="NA" /TUlongPSig="NA" /label="S1157" upshifts 2756553 /Source="Nicolas_upshifts" /id="U2351" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.978021978021978" /psig="0.978021978021978" /xcortree=1009 /SigmaFactorBS="atctaactgtattttatagaattctgTTCATAagtgcaagca ggtttGTATACAATGGGAATGTACcctgaacgggcggagattgaggacaattattcgg g" /listShort="S1157" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2756585..2756920) /gene="ytvB" /locus_tag="BSU_30330" /old_locus_tag="BSU30330" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16923906; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative conserved membrane protein" /protein_id="NP_390911.3" /db_xref="EnsemblGenomes-Gn:BSU30330" /db_xref="EnsemblGenomes-Tr:CAB15011" /db_xref="GOA:O34881" /db_xref="InterPro:IPR025353" /db_xref="SubtiList:BG13929" /db_xref="UniProtKB/Swiss-Prot:O34881" /translation="MKMLHQVLIACVIGGIMGILGHVKKRGRLEKPRMTKRFIYLGFL EDWFIGMTASILLVLSADPDSGIQLVILSIISGYGGEAVLRSFDFVRELNSGGEPAES KRQTKTPPE*" /label="ytvB CDS" gene complement(2756585..2756920) /gene="ytvB" /locus_tag="BSU_30330" /old_locus_tag="BSU30330" /label="ytvB gene" S_feature complement(2756915..2757179) /Source="Nicolas_S_feature" /locus_tag="new_3105800_3106064_c" /HighExp="S6, S8, S7, Etha, S5, M9-stat, B60, BT, B36, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.989" /TUlongSig="NA" /TUlongPSig="NA" /label="S1158" promotor_-10 complement(2757164..2757183) /Source="Nicolas_upshift_promotors" /id="U2352" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig="0.98901098901099" /xcortree=780 /SigmaFactorBS="aacacatgttctgattcaagcaagtgcagtttgtTGTTTGTC attagggcttgtccTCGTATACACTAAAAATAAGaacagaatttgaacatatgaacgg a" /listShort="S1158, ytvB, NA" /listLong="S1156, leuS" /label="promotor_-10" upshifts complement(2757179) /Source="Nicolas_upshifts" /id="U2352" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig="0.98901098901099" /xcortree=780 /SigmaFactorBS="aacacatgttctgattcaagcaagtgcagtttgtTGTTTGTC attagggcttgtccTCGTATACACTAAAAATAAGaacagaatttgaacatatgaacgg a" /listShort="S1158, ytvB, NA" /listLong="S1156, leuS" /label="upshifts" promotor_-35 complement(2757198..2757205) /Source="Nicolas_upshift_promotors" /id="U2352" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95004995004995" /psig="0.98901098901099" /xcortree=780 /SigmaFactorBS="aacacatgttctgattcaagcaagtgcagtttgtTGTTTGTC attagggcttgtccTCGTATACACTAAAAATAAGaacagaatttgaacatatgaacgg a" /listShort="S1158, ytvB, NA" /listLong="S1156, leuS" /label="promotor_-35" promotor_-35 2757218..2757225 /Source="Nicolas_upshift_promotors" /id="U2353" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.887112887112887" /psig="0.997002997002997" /xcortree=2073 /SigmaFactorBS="aatgacaaacaacaaactgcactTGCTTGAAtcagaacatgt gtTGTGCTACGGTTACTGTAGAattcatttttaaaaaggggaatatcaggctttcgca t" /listShort="S1159, ytvA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2757239..2757258 /Source="Nicolas_upshift_promotors" /id="U2353" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.887112887112887" /psig="0.997002997002997" /xcortree=2073 /SigmaFactorBS="aatgacaaacaacaaactgcactTGCTTGAAtcagaacatgt gtTGTGCTACGGTTACTGTAGAattcatttttaaaaaggggaatatcaggctttcgca t" /listShort="S1159, ytvA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2757255 /Source="Nicolas_upshifts" /id="U2353" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.887112887112887" /psig="0.997002997002997" /xcortree=2073 /SigmaFactorBS="aatgacaaacaacaaactgcactTGCTTGAAtcagaacatgt gtTGTGCTACGGTTACTGTAGAattcatttttaaaaaggggaatatcaggctttcgca t" /listShort="S1159, ytvA" /GFF_Attribute="listLong" /label="upshifts" S_feature 2757257..2757324 /Source="Nicolas_S_feature" /locus_tag="new_3106142_3106209" /HighExp="M40t90, Etha, dia5, HiOs, dia15, H2O2, BC, Diami, M0t90, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1159" CDS 2757325..2758110 /gene="blrA" /locus_tag="BSU_30340" /old_locus_tag="BSU30340" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11964249, 16923906, 16923909, 17200735, 17443319, 17575448, 19948797, 21259411, 21851109, 23416074, 24171435, 25211155, 27203230, 28502782, 28632317" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11964249, 16923906, 16923909, 17200735, 17443319, 17575448, 19948797, 21259411, 21851109, 23416074, 24171435, 25211155, 27203230, 28502782, 28632317; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="blue light GTP-binding receptor" /protein_id="NP_390912.1" /db_xref="EnsemblGenomes-Gn:BSU30340" /db_xref="EnsemblGenomes-Tr:CAB15012" /db_xref="GOA:O34627" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR000700" /db_xref="InterPro:IPR001610" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036513" /db_xref="PDB:1IUM" /db_xref="PDB:2MWG" /db_xref="PDB:2PR5" /db_xref="PDB:2PR6" /db_xref="PDB:4GCZ" /db_xref="SubtiList:BG13928" /db_xref="UniProtKB/Swiss-Prot:O34627" /translation="MASFQSFGIPGQLEVIKKALDHVRVGVVITDPALEDNPIVYVNQ GFVQMTGYETEEILGKNCRFLQGKHTDPAEVDNIRTALQNKEPVTVQIQNYKKDGTMF WNELNIDPMEIEDKTYFVGIQNDITKQKEYEKLLEDSLTEITALSTPIVPIRNGISAL PLVGNLTEERFNSIVCTLTNILSTSKDDYLIIDLSGLAQVNEQTADQIFKLSHLLKLT GTELIITGIKPELAMKMNKLDANFSSLKTYSNVKDAVKVLPIM*" /label="blrA CDS" gene 2757325..2758110 /gene="blrA" /locus_tag="BSU_30340" /old_locus_tag="BSU30340" /label="blrA gene" S_feature 2758111..2758167 /Source="Nicolas_S_feature" /locus_tag="new_3106996_3107052" /HighExp="Sw, M40t90, BC, Etha, dia5, dia15, H2O2, Mt0, M0t90, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1160" CDS complement(2758347..2759540) /gene="yttB" /locus_tag="BSU_30350" /old_locus_tag="BSU30350" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11988534, 15849754, 16850406, 28472044; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_390913.1" /db_xref="EnsemblGenomes-Gn:BSU30350" /db_xref="EnsemblGenomes-Tr:CAB15013" /db_xref="GOA:O34546" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13925" /db_xref="UniProtKB/Swiss-Prot:O34546" /translation="MPRALKILVIGMFINVTGASFLWPLNTIYIHNHLGKSLTVAGLV LMLNSGASVAGNLCGGFLFDKIGGFKSIMLGIAITLASLMGLVFFHDWPAYIVLLTIV GFGSGVVFPASYAMAGSVWPEGGRKAFNAIYVAQNAGVAVGSALGGVVASFSFSYVFL ANAVLYLIFFFIVYFGFRNIQTGDASQTSVLDYDAVNSKAKFAALIILSGGYVLGWLA YSQWSTTIASYTQSIGISLSLYSVLWTVNGILIVLGQPLVSFVVKKWAESLKAQMVIG FIIFIVSFSMLLTAKQFPMFLAAMVILTIGEMLVWPAVPTIANQLAPKGKEGFYQGFV NSAATGGRMIGPLFGGVLVDHYGIRALVLSLLVLLLISIATTLLYDKRIKSAKETNKQ ASISS*" /label="yttB CDS" gene complement(2758347..2759540) /gene="yttB" /locus_tag="BSU_30350" /old_locus_tag="BSU30350" /label="yttB gene" downshifts complement(2758367) /Source="Nicolas_upshifts" /id="D1562" /incds=0 /nref=5 /ntot=47 /MaxReadThrough="2.03991" /MaxDrop="3.41948" /score="-7.70376219" /energy="-9.4" /TU="NA" /idTUdmin="U2354" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2759541..2759639) /Source="Nicolas_S_feature" /locus_tag="new_3108426_3108524_c" /HighExp="dia15, LBGstat, H2O2, G180, LPhT, Paraq, Oxctl, G150, G135, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1161" promotor_-10 complement(2759620..2759639) /Source="Nicolas_upshift_promotors" /id="U2354" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2464 /SigmaFactorBS="atttttcaaacaatatttgttagattttttcacgctcatCAG TTGAAaaatgtgagagagACAGATAGAATGAATGTGCTatgataactggattcgtacg g" /listShort="S1161, yttB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2759639) /Source="Nicolas_upshifts" /id="U2354" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2464 /SigmaFactorBS="atttttcaaacaatatttgttagattttttcacgctcatCAG TTGAAaaatgtgagagagACAGATAGAATGAATGTGCTatgataactggattcgtacg g" /listShort="S1161, yttB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2759653..2759660) /Source="Nicolas_upshift_promotors" /id="U2354" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2464 /SigmaFactorBS="atttttcaaacaatatttgttagattttttcacgctcatCAG TTGAAaaatgtgagagagACAGATAGAATGAATGTGCTatgataactggattcgtacg g" /listShort="S1161, yttB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2759677..2759680 /Source="Nicolas_upshift_promotors" /id="U2355" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig="0.987012987012987" /xcortree=3214 /SigmaFactorBS="tctctctcacatttttcaactgatgagcgtgaaaaaatCTAA caaatattgtttgaAAAATGTAAAATAAATAGAAaaaggggtcatattatggaaatgg t" /listShort="yttA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2759695..2759714 /Source="Nicolas_upshift_promotors" /id="U2355" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig="0.987012987012987" /xcortree=3214 /SigmaFactorBS="tctctctcacatttttcaactgatgagcgtgaaaaaatCTAA caaatattgtttgaAAAATGTAAAATAAATAGAAaaaggggtcatattatggaaatgg t" /listShort="yttA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2759699 /Source="Nicolas_upshifts" /id="U2355" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig="0.987012987012987" /xcortree=3214 /SigmaFactorBS="tctctctcacatttttcaactgatgagcgtgaaaaaatCTAA caaatattgtttgaAAAATGTAAAATAAATAGAAaaaggggtcatattatggaaatgg t" /listShort="yttA" /GFF_Attribute="listLong" /label="upshifts" CDS 2759729..2760475 /gene="yttA" /locus_tag="BSU_30360" /old_locus_tag="BSU30360" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12823818" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390914.2" /db_xref="EnsemblGenomes-Gn:BSU30360" /db_xref="EnsemblGenomes-Tr:CAB15014" /db_xref="GOA:Q795Q5" /db_xref="InterPro:IPR006876" /db_xref="InterPro:IPR035451" /db_xref="SubtiList:BG13924" /db_xref="UniProtKB/Swiss-Prot:Q795Q5" /translation="MEMVLAFLGFLACLIALGYGLYHLVRYVLKKEKRFSKRLFWPLF IGGLVLLFTGAALAEPDTAAANAEKKYSALNAEYKNLTKEHEELEKEYKSVSSEAKKL KDNKEDQDKLEKLKNENSDLKKTQKSLKAEIKELQENQKQLKEDAKTAKAENETLRQD KTKLENQLKETESQTASSHEDTGSSSNNTSKSDETKTADKAEGCNIKGSRNGIYHTPG STYYDRTTDPAEMFCSVEEAEAAGYRAPKR*" /label="yttA CDS" gene 2759729..2760475 /gene="yttA" /locus_tag="BSU_30360" /old_locus_tag="BSU30360" /label="yttA gene" downshifts 2760370 /Source="Nicolas_upshifts" /id="D1563" /incds=1 /nref=2 /ntot=94 /MaxReadThrough="4.11368" /MaxDrop="3.01036" /score="23.2955589" /energy="-11.6" /TU="U2355" /idTUdmin="U2355" /TUdmin="-99" /isTUend="FALSE" /label="downshifts" downshifts 2760469 /Source="Nicolas_upshifts" /id="D1564" /incds=0 /nref=31 /ntot=169 /MaxReadThrough="1.73994" /MaxDrop="4.19129" /score="23.2955589" /energy="-11.6" /TU="NA" /idTUdmin="U2355" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2760512..2762452) /gene="bceB" /locus_tag="BSU_30370" /old_locus_tag="BSU30370" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:14612242, 15849754, 16850406, 17905982, 25118291" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14612242, 15849754, 16850406, 17905982, 25118291; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (permease)" /protein_id="NP_390915.1" /db_xref="EnsemblGenomes-Gn:BSU30370" /db_xref="EnsemblGenomes-Tr:CAB15015" /db_xref="GOA:O34741" /db_xref="InterPro:IPR003838" /db_xref="InterPro:IPR027022" /db_xref="SubtiList:BG13921" /db_xref="UniProtKB/Swiss-Prot:O34741" /translation="MNINQLILRNLKKNLRNYYLYVFALIFSVALYFAFVTLQYDPAI NEVKASIKGAAAIKTASILLVAVVAIFILYANTIFIKRRSKEIGLFQLIGMTKHKIFR ILSAENVMLYFGSLAIGVAAGFSISKLVLMILFKIVDVKADAKLHFSEQALVQTVIVF CGIYLLIMIMNYTFIKKQSILSLFKVTSSTEDKVKKISFFQMLIGALGIVLILTGYYV SSELFGGKFKTINELFVAMSFILGSVIIGTFLFYKGSVTFISNIIRKSKGGYLNISEV LSLSSIMFRMKSNALLLTIITTVSALAIGLLSLAYISYYSSEKTAEQNVAADFSFMNE KDAKLFENKLRESNISFVKKATPVLQANVDIANIMDGTPKEMQGDPGNMQLAVVSDKD VKGVDVAAGEAVFSGYTDLLQKIMVFKDSGVIKVKSKHETQPLKYKGLREEFLVSYTF TSGGMPAVIVDDSLFKQLDKDKDPRIQLAQSTFIGVNVKHDDQMEKANELFQQVNKKN EHLSRLDTSAAQKSLFGMVMFIVGFLGLTFLITSGCILYFKQMGESEDEKPSYTILRK LGFTQGDLIKGIRIKQMYNFGIPLVVGLFHSYFAVQSGWFLFGSEVWAPMIMVMVLYT ALYSIFGFLSVLYYKKVIKSSL*" /label="bceB CDS" gene complement(2760512..2762452) /gene="bceB" /locus_tag="BSU_30370" /old_locus_tag="BSU30370" /label="bceB gene" downshifts complement(2760523) /Source="Nicolas_upshifts" /id="D1565" /incds=0 /nref=13 /ntot=89 /MaxReadThrough="1.56566" /MaxDrop="4.45006" /score="29.4802229" /energy="-11.6" /TU="NA" /idTUdmin="U2356" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2762442..2763203) /gene="bceA" /locus_tag="BSU_30380" /old_locus_tag="BSU30380" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:14612242, 17905982, 25118291" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14612242, 17905982, 25118291; Product type t: transporter" /codon_start=1 /transl_table=11 /product="bacitracin ABC efflux transporter (ATP-binding protein)" /protein_id="NP_390916.1" /db_xref="EnsemblGenomes-Gn:BSU30380" /db_xref="EnsemblGenomes-Tr:CAB15016" /db_xref="GOA:O34697" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13920" /db_xref="UniProtKB/Swiss-Prot:O34697" /translation="MVILEANKIRKSYGNKLNKQEVLKGIDIHIEKGEFVSIMGASGS GKTTLLNVLSSIDQVSHGTIHINGNDMTAMKEKQLAEFRKQHLGFIFQDYNLLDTLTV KENILLPLSITKLSKKEANRKFEEVAKELGIYELRDKYPNEISGGQKQRTSAGRAFIH DPSIIFADEPTGALDSKSASDLLNKLSQLNQKRNATIIMVTHDPVAASYCGRVIFIKD GQMYTQLNKGGQDRQTFFQDIMKTQGVLGGVQHEH*" /label="bceA CDS" gene complement(2762442..2763203) /gene="bceA" /locus_tag="BSU_30380" /old_locus_tag="BSU30380" /label="bceA gene" misc_feature complement(2763227..2763245) /Source="Nicolas_upshift_promotors" /id="U2356" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.383616383616384" /psig="0.83016983016983" /xcortree=3191 /SigmaFactorBS="gacgaaaatgtcacatgcttttcttttttgttcgccgtatcg aaggaaaagcccggcattcCTTTTTATAATGAGATTATccaatataaaggagactgcg t" /listShort="bceA, bceB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2763246) /Source="Nicolas_upshifts" /id="U2356" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.383616383616384" /psig="0.83016983016983" /xcortree=3191 /SigmaFactorBS="gacgaaaatgtcacatgcttttcttttttgttcgccgtatcg aaggaaaagcccggcattcCTTTTTATAATGAGATTATccaatataaaggagactgcg t" /listShort="bceA, bceB" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2763305..2764309) /gene="bceS" /locus_tag="BSU_30390" /old_locus_tag="BSU30390" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 17905982, 25118291, 25685323" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 17905982, 25118291, 25685323; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase controlling resistance to antibiotics affecting the envelope [YtsA]" /protein_id="NP_390917.1" /db_xref="EnsemblGenomes-Gn:BSU30390" /db_xref="EnsemblGenomes-Tr:CAB15017" /db_xref="GOA:O35044" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG13919" /db_xref="UniProtKB/Swiss-Prot:O35044" /translation="MIKAFLIERRSWIAAFLFQQALMLFIAFVDPSISFGNVLYMVYL CILFFIIFLWFRYRKETAFYKSLKTWENNLDVTAINEPETPFEAMVERSIAGQTEHLK QTAARHRLALENEKDELMAWIHEVKTPLTAMHLIIDRMEEKALKSQLSYEWLRIHLLL DQQLHQKRISFIENDLSVEFIQLQPLIFKEIKDLQSWCIQKGIGFDIQLEAKEVLSDA KWLAFIIRQLLTNAVKYSEASEIEIKSFQKGEQTQLQVKDCGRGIDPKDVPRIFDKGF TSTTDHHDQASTGMGLYLAKKAAAPLLIHIDVESEFGAGTVFTLTFPIRNQFEHVISV *" /label="bceS CDS" gene complement(2763305..2764309) /gene="bceS" /locus_tag="BSU_30390" /old_locus_tag="BSU30390" /label="bceS gene" downshifts complement(2763344) /Source="Nicolas_upshifts" /id="D1566" /incds=0 /nref=25 /ntot=187 /MaxReadThrough="2.40611" /MaxDrop="4.6482" /score="29.3236847" /energy="-13.9" /TU="NA" /idTUdmin="U2357" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" CDS complement(2764302..2764997) /gene="bceR" /locus_tag="BSU_30400" /old_locus_tag="BSU30400" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 17905982, 25118291, 25685323, 27997719" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 17905982, 25118291, 25685323, 27997719; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator controlling resistance to antibiotics affecting the envelope [YtsB]" /protein_id="NP_390918.1" /db_xref="EnsemblGenomes-Gn:BSU30400" /db_xref="EnsemblGenomes-Tr:CAB15018" /db_xref="GOA:O34951" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12340" /db_xref="UniProtKB/Swiss-Prot:O34951" /translation="MFKLLLIEDDESLFHEIKDRLTGWSYDVYGIQDFSQVLQEFAAV NPDCVIIDVQLPKFDGFHWCRLIRSRSNVPILFLSSRDHPADMVMSMQLGADDFIQKP FHFDVLIAKIQAMFRRVHHYNTEPSTIKTWCGAAVDAEQNLVSNDKGSVELTKNEMFI LKQLIEQKNKIVSREELIRSLWNDERFVSDNTLTVNVNRLRKKLDALQLGAYIETKVG QGYIAKEEDKFYD*" /label="bceR CDS" gene complement(2764302..2764997) /gene="bceR" /locus_tag="BSU_30400" /old_locus_tag="BSU30400" /label="bceR gene" promotor_-10 complement(2765021..2765039) /Source="Nicolas_upshift_promotors" /id="U2357" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.47952047952048" /psig="0.987012987012987" /xcortree=3119 /SigmaFactorBS="tgcgaacgagccggctgagacagccggctttttctATAGcgc atgctggcgtttTGCTATACACTTGATAAAAaaggaaaaagtgcggtgagtcgattgt t" /listShort="bceR, bceS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2765033) /Source="Nicolas_upshifts" /id="U2357" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.47952047952048" /psig="0.987012987012987" /xcortree=3119 /SigmaFactorBS="tgcgaacgagccggctgagacagccggctttttctATAGcgc atgctggcgtttTGCTATACACTTGATAAAAaaggaaaaagtgcggtgagtcgattgt t" /listShort="bceR, bceS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2765055..2765058) /Source="Nicolas_upshift_promotors" /id="U2357" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.47952047952048" /psig="0.987012987012987" /xcortree=3119 /SigmaFactorBS="tgcgaacgagccggctgagacagccggctttttctATAGcgc atgctggcgtttTGCTATACACTTGATAAAAaaggaaaaagtgcggtgagtcgattgt t" /listShort="bceR, bceS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2765094..2766404) /gene="ytrF" /locus_tag="BSU_30410" /old_locus_tag="BSU30410" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10986249, 15849754, 16850406, 17558661, 22926563" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10986249, 15849754, 16850406, 17558661, 22926563; Product type t : transporter" /codon_start=1 /transl_table=11 /product="metabolite permease involved in resistance to cell wall inhibitors" /protein_id="NP_390919.1" /db_xref="EnsemblGenomes-Gn:BSU30410" /db_xref="EnsemblGenomes-Tr:CAB15019" /db_xref="GOA:O35005" /db_xref="InterPro:IPR003838" /db_xref="InterPro:IPR025857" /db_xref="SubtiList:BG13916" /db_xref="UniProtKB/Swiss-Prot:O35005" /translation="MRFKDQVHFIRRNMKKNRLRVFMTILATTMACAFLVVLSSVGFG IQKTITDMTMSQQIVTKVSVMGKEGDKPIKKADLEKYDHVRSVVERTQVYEPNKATLG NRTNESSNLIFTNMNDELKANMELEKGRVAKSENEIVVGYDFAKRLLTKKESEEYNKK IEEAKGNPEDIKEPKGYTKDILNKTIELSVSKTDSKTGDVTKTKTYDFKIVGITKKPS QDWMEDSNIFISDQFKKDFSEFLDFKGGNVETNIGVFADKFENVEQLTNDLTDDGYYV TSVTTELEGANTFFMVFKIGLIFVGCIAVIISAIGIFNTMTMAVTERTQEIGIMKAIG ASPSIIRRMFLMESAYIGILGCVIGIIISYGVSYLVNLAVPMILAATSGGDAGDLNYT FSYIPASLVIIAVVICGGVAVISGMNPARKATKTNVLTALRREL*" /label="ytrF CDS" gene complement(2765094..2766404) /gene="ytrF" /locus_tag="BSU_30410" /old_locus_tag="BSU30410" /label="ytrF gene" downshifts complement(2765116) /Source="Nicolas_upshifts" /id="D1567" /incds=0 /nref=9 /ntot=170 /MaxReadThrough="4.26891" /MaxDrop="3.83905" /score="28.2472037" /energy="-13.6" /TU="U2359" /idTUdmin="U2359" /TUdmin="-1755" /isTUend="FALSE" /label="downshifts" CDS complement(2766394..2767089) /gene="ytrE" /locus_tag="BSU_30420" /old_locus_tag="BSU30420" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10986249, 22720735, 22926563" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10986249, 22720735, 22926563; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (ATP-binding protein) involved in resistance to cell wall inhibitors" /protein_id="NP_390920.1" /db_xref="EnsemblGenomes-Gn:BSU30420" /db_xref="EnsemblGenomes-Tr:CAB15020" /db_xref="GOA:O34392" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13915" /db_xref="UniProtKB/Swiss-Prot:O34392" /translation="MIDVQHIDHSFTIGKKGRENEVPVLKDVSLSVAKGEIACIVGRS GSGKSTLLNLISGYISPTKGRIVINGTDVTGFNEKEWAQFRLDHFGFIFQSFQLIPGL TTYENVEMPLALKGIKPSERKQKVQDMLKRVGLENHAAHYPNELSGGQQQRVSIARAL ILNPSIILADEPTGSLDSETEHEVLELIQQLNRERGITFVIITHDDEVASIGHSKFQL HDGVLKGGITVEV*" /label="ytrE CDS" gene complement(2766394..2767089) /gene="ytrE" /locus_tag="BSU_30420" /old_locus_tag="BSU30420" /label="ytrE gene" CDS complement(2767104..2768081) /gene="ytrD" /locus_tag="BSU_30430" /old_locus_tag="BSU30430" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10986249, 15849754, 16850406, 17558661, 22926563" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10986249, 15849754, 16850406, 17558661, 22926563; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC transporter, permease component involved in resistance to cell wall inhibitors" /protein_id="NP_390921.1" /db_xref="EnsemblGenomes-Gn:BSU30430" /db_xref="EnsemblGenomes-Tr:CAB15021" /db_xref="GOA:O34953" /db_xref="InterPro:IPR023264" /db_xref="SubtiList:BG13914" /db_xref="UniProtKB/Swiss-Prot:O34953" /translation="MPDSGLLYKEWRQNKVALVITILVFILGNPLSILNMYLIYQGCV TGKENWVGPCVFSVDYLNSSFISLFWIWGVVLAVSQLGIERSKSFFDFTLSLPYTRGQ IFHAKFLTGGMVIVVPQLIGYVLSVLLIMLLKPDQAVYFHNYSLGMIIVSMLAYSLVM AGGALTGNSFAQLLVSFTVAISPFLLISLPVINLEILFGGSIDFIHGPVPKWVQYFIP IIYVDSKWAENSPYYLVIPAIMTIIFYIIGYISFVKMSNERNGYFFLWKPLNRPVQII VIIIGIMGFGYFGFTASESFAGYLIGMGTGAVIGFLISYFAIYKKMKLL*" /label="ytrD CDS" gene complement(2767104..2768081) /gene="ytrD" /locus_tag="BSU_30430" /old_locus_tag="BSU30430" /label="ytrD gene" CDS complement(2768111..2769097) /gene="ytrC" /locus_tag="BSU_30440" /old_locus_tag="BSU30440" /experiment="publication(s) with functional evidences, PMID:10986249, 15849754, 16850406, 17558661, 22926563" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10986249, 15849754, 16850406, 17558661, 22926563; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC transporter, permease component involved in resistance to cell wall inhibitors" /protein_id="NP_390922.1" /db_xref="EnsemblGenomes-Gn:BSU30440" /db_xref="EnsemblGenomes-Tr:CAB15022" /db_xref="GOA:O34898" /db_xref="InterPro:IPR023264" /db_xref="SubtiList:BG13913" /db_xref="UniProtKB/Swiss-Prot:O34898" /translation="MVDRGLLYREWKQNQVVILLSIAFLVLANPLSIVNTYLSYQGCL DRQDPQYCDFIVNYSISNLIDINWVPGVILAVCFLGMERSKGTMDFILSLPYNRSQIF QTKFWLGGFVIVLSQLIGFLLAWLLILVYNPEHVYFFEHSSIGVIVISFMAFSLVMAA GALTGNAFAQLLTAFSAAILPYLIIALPVGNLEVVFGANIWEIFPSPESYFSLASNLS NLVPISYVVNEWLINSKYLLLIPAVMSMLFYLIGFISFKKLPSERNGHFFLWNRLDRP VQILVMAFGILGFGLFGYYTGHSIIGYILGMIIGAVAGFFVSYFSIYKKTKV*" /label="ytrC CDS" gene complement(2768111..2769097) /gene="ytrC" /locus_tag="BSU_30440" /old_locus_tag="BSU30440" /label="ytrC gene" promotor_-35 2768967..2768976 /Source="Nicolas_upshift_promotors" /id="U2358" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1713 /SigmaFactorBS="aataattcacaataaaatcacaatattgcgggtcttggcgat caAGACACCCTTgataagacaaatACGTATTAACGATAGAaagcggatttgccaatac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2768983 /Source="Nicolas_upshifts" /id="U2358" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1713 /SigmaFactorBS="aataattcacaataaaatcacaatattgcgggtcttggcgat caAGACACCCTTgataagacaaatACGTATTAACGATAGAaagcggatttgccaatac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2768989..2769004 /Source="Nicolas_upshift_promotors" /id="U2358" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1713 /SigmaFactorBS="aataattcacaataaaatcacaatattgcgggtcttggcgat caAGACACCCTTgataagacaaatACGTATTAACGATAGAaagcggatttgccaatac t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2769091..2769969) /gene="ytrB" /locus_tag="BSU_30450" /old_locus_tag="BSU30450" /EC_number="3.6.3.-" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10986249, 22926563" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10986249, 22926563; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (ATP-binding protein) involved in resistance to cell wall inhibitors" /protein_id="NP_390923.1" /db_xref="EnsemblGenomes-Gn:BSU30450" /db_xref="EnsemblGenomes-Tr:CAB15023" /db_xref="GOA:O34641" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13912" /db_xref="UniProtKB/Swiss-Prot:O34641" /translation="MIELRQLSKAIDGNQVLKDVSLTIEKGEIFGLLGRNGSGKTTML RLIQQIIFADSGTILFDGVEIKKHPKVKQNIIYMPVQNPFYDKYTYKQLVDILRRIYP KFDVTYANELMNRYEIPETKKYRELSTGLKKQLSLVLSFAARPALILLDEPTDGIDAV TRHDVLQLMVDEVAERDTSILITSHRLEDIERMCNRIGFLEDNSLTNVMDLDELKEEY IKIQMAFDTDVNLAIREQNIPMLDQAGVFYTVLIPKSDEEKKSFLRELKPKVWNELPV NLEEVFIAKFGGKRRW*" /label="ytrB CDS" gene complement(2769091..2769969) /gene="ytrB" /locus_tag="BSU_30450" /old_locus_tag="BSU30450" /label="ytrB gene" CDS complement(2769962..2770354) /gene="ytrA" /locus_tag="BSU_30460" /old_locus_tag="BSU30460" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10986249, 11756427, 17194626, 21856850, 28357385" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10986249, 11756427, 17194626, 21856850, 28357385; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (GntR family, cell wall antibiotics)" /protein_id="NP_390924.1" /db_xref="EnsemblGenomes-Gn:BSU30460" /db_xref="EnsemblGenomes-Tr:CAB15024" /db_xref="GOA:O34712" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13911" /db_xref="UniProtKB/Swiss-Prot:O34712" /translation="MIQIDPRSSTPIYEQIIQQMKELCLKGIMKPGDKLPSVRELATI IIANPNTVSKAYKELEREGIIETLRGRGTYISENAKTTLVEGKMTMIKEQLKQLIIDA HYAGVELEKLHEWIKEISADVKGGKKND*" /label="ytrA CDS" gene complement(2769962..2770354) /gene="ytrA" /locus_tag="BSU_30460" /old_locus_tag="BSU30460" /label="ytrA gene" S_feature complement(2770355..2770599) /Source="Nicolas_S_feature" /locus_tag="new_3119240_3119484_c" /HighExp="Cold, Salt, SMMPr, MG 15, M9-tran, G180, M9-exp, M/G, MG 25, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.71885600000000005" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1162" CDS complement(2770388..2770525) /locus_tag="BSU_30466" /old_locus_tag="BSU30466" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 28357385" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_009513999.1" /db_xref="EnsemblGenomes-Gn:BSU30466" /db_xref="EnsemblGenomes-Tr:CCQ48604" /db_xref="GOA:L8ECR1" /db_xref="UniProtKB/TrEMBL:L8ECR1" /translation="MKHKKRNKRNVPMLIAASVIACSFFLVLVMIGFEWQKSIIDHFY L*" /label="conserved protein of unknown function CDS" gene complement(2770388..2770525) /locus_tag="BSU_30466" /old_locus_tag="BSU30466" /label="gene" downshifts 2770523 /Source="Nicolas_upshifts" /id="D1568" /incds=0 /nref=1 /ntot=4 /MaxReadThrough="2.62989" /MaxDrop="3.1332" /score="6.69010243" /energy="-14.4" /TU="NA" /idTUdmin="U2361" /TUdmin="-1254" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2770594..2770613) /Source="Nicolas_upshift_promotors" /id="U2359" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.795204795204795" /psig="0.998001998001998" /xcortree=2536 /SigmaFactorBS="gggtccgtttttttgtaaaaaaaggATTGACTTtgtgagtca aagtATTTATTGTATTAAGTGTACtaattgaagtaatacactatagacactaatataa a" /listShort="S1162, ytrA, ytrB, ytrC, ytrD, ytrE, ytrF, bceR, bceS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2770599) /Source="Nicolas_upshifts" /id="U2359" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.795204795204795" /psig="0.998001998001998" /xcortree=2536 /SigmaFactorBS="gggtccgtttttttgtaaaaaaaggATTGACTTtgtgagtca aagtATTTATTGTATTAAGTGTACtaattgaagtaatacactatagacactaatataa a" /listShort="S1162, ytrA, ytrB, ytrC, ytrD, ytrE, ytrF, bceR, bceS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2770627..2770634) /Source="Nicolas_upshift_promotors" /id="U2359" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.795204795204795" /psig="0.998001998001998" /xcortree=2536 /SigmaFactorBS="gggtccgtttttttgtaaaaaaaggATTGACTTtgtgagtca aagtATTTATTGTATTAAGTGTACtaattgaagtaatacactatagacactaatataa a" /listShort="S1162, ytrA, ytrB, ytrC, ytrD, ytrE, ytrF, bceR, bceS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2770680..2770952) /gene="ytzC" /locus_tag="BSU_30470" /old_locus_tag="BSU30470" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390925.1" /db_xref="EnsemblGenomes-Gn:BSU30470" /db_xref="EnsemblGenomes-Tr:CAB15025" /db_xref="InterPro:IPR019668" /db_xref="SubtiList:BG13937" /db_xref="UniProtKB/Swiss-Prot:O32073" /translation="MATRQSVDEHLQQCMQAYDYAEEQLKIASKQEHYNDQEYSDAQM QLEDAVNALNKLWLSSNDQQREQLYRMRLQLQSLQNNMILQHPLDV*" /label="ytzC CDS" gene complement(2770680..2770952) /gene="ytzC" /locus_tag="BSU_30470" /old_locus_tag="BSU30470" /label="ytzC gene" downshifts complement(2770687) /Source="Nicolas_upshifts" /id="D1569" /incds=0 /nref=1 /ntot=36 /MaxReadThrough="2.96566" /MaxDrop="8.4811" /score="36.3100501" /energy="-14.4" /TU="NA" /idTUdmin="U2360" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2770992..2771003) /Source="Nicolas_upshift_promotors" /id="U2360" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.743256743256743" /psig="0.743256743256743" /xcortree=824 /SigmaFactorBS="agagaacaaatgaatatcgaccataaattactTTATTGAata aagtcagatgaGGCTACAATATGaatgatggatgatttccattaccaagaggaggggt t" /listShort="ytzC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 2770996..2771004 /Source="Nicolas_upshift_promotors" /id="U2361" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.724275724275724" /psig="0.724275724275724" /xcortree=1265 /SigmaFactorBS="tgccacagtaacccctcctcttggtaatggaaatcatccatc attcataTTGTAGCCTcatctgactttatTCAATAAAGTAATTTATGGtcgatattca t" /listShort="ytqA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2770996) /Source="Nicolas_upshifts" /id="U2360" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.743256743256743" /psig="0.743256743256743" /xcortree=824 /SigmaFactorBS="agagaacaaatgaatatcgaccataaattactTTATTGAata aagtcagatgaGGCTACAATATGaatgatggatgatttccattaccaagaggaggggt t" /listShort="ytzC" /GFF_Attribute="listLong" /label="upshifts" upshifts 2771007 /Source="Nicolas_upshifts" /id="U2361" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.724275724275724" /psig="0.724275724275724" /xcortree=1265 /SigmaFactorBS="tgccacagtaacccctcctcttggtaatggaaatcatccatc attcataTTGTAGCCTcatctgactttatTCAATAAAGTAATTTATGGtcgatattca t" /listShort="ytqA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2771018..2771024) /Source="Nicolas_upshift_promotors" /id="U2360" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.743256743256743" /psig="0.743256743256743" /xcortree=824 /SigmaFactorBS="agagaacaaatgaatatcgaccataaattactTTATTGAata aagtcagatgaGGCTACAATATGaatgatggatgatttccattaccaagaggaggggt t" /listShort="ytzC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2771018..2771036 /Source="Nicolas_upshift_promotors" /id="U2361" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.724275724275724" /psig="0.724275724275724" /xcortree=1265 /SigmaFactorBS="tgccacagtaacccctcctcttggtaatggaaatcatccatc attcataTTGTAGCCTcatctgactttatTCAATAAAGTAATTTATGGtcgatattca t" /listShort="ytqA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 2771047..2771052 /Source="Nicolas_upshift_promotors" /id="U2362" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2496 /SigmaFactorBS="tttattcaataaagtaatttatggtcgatattcaTTTGTTct cttgtgaaatgCGTGCTACAATTTTAGGATGcaatcgtacgcaaggaggcacatgaat t" /listShort="ytqA, ytqB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2771066..2771085 /Source="Nicolas_upshift_promotors" /id="U2362" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2496 /SigmaFactorBS="tttattcaataaagtaatttatggtcgatattcaTTTGTTct cttgtgaaatgCGTGCTACAATTTTAGGATGcaatcgtacgcaaggaggcacatgaat t" /listShort="ytqA, ytqB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2771073 /Source="Nicolas_upshifts" /id="U2362" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.492507492507492" /psig=1 /xcortree=2496 /SigmaFactorBS="tttattcaataaagtaatttatggtcgatattcaTTTGTTct cttgtgaaatgCGTGCTACAATTTTAGGATGcaatcgtacgcaaggaggcacatgaat t" /listShort="ytqA, ytqB" /GFF_Attribute="listLong" /label="upshifts" CDS 2771114..2772082 /gene="ytqA" /locus_tag="BSU_30480" /old_locus_tag="BSU30480" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10413665; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_390926.1" /db_xref="EnsemblGenomes-Gn:BSU30480" /db_xref="EnsemblGenomes-Tr:CAB15026" /db_xref="GOA:O35008" /db_xref="InterPro:IPR005911" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR032432" /db_xref="SubtiList:BG13908" /db_xref="UniProtKB/Swiss-Prot:O35008" /translation="MMQNNPFPYSNTEKRYHTLNYHLREHFGHKVFKVALDGGFDCPN RDGTVAHGGCTFCSAAGSGDFAGNRTDDLITQFHDIKNRMHEKWKDGKYIAYFQAFTN THAPVEVLREKFESVLALDDVVGISIATRPDCLPDDVVDYLAELNERTYLWVELGLQT VHERTALLINRAHDFNCYVEGVNKLRKHGIRVCSHIINGLPLEDRDMMMETAKAVADL DVQGIKIHLLHLLKGTPMVKQYEKGKLEFLSQDDYVQLVCDQLEIIPPEMIVHRITGD GPIELMIGPMWSVNKWEVLGAINKELENRGSYQGKFFQRLEEESAL*" /label="ytqA CDS" gene 2771114..2772082 /gene="ytqA" /locus_tag="BSU_30480" /old_locus_tag="BSU30480" /label="ytqA gene" CDS 2772079..2772663 /gene="ytqB" /locus_tag="BSU_30490" /old_locus_tag="BSU30490" /EC_number="2.1.1.-" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16014871, 22333191, 24699744; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA methylase" /protein_id="NP_390927.1" /db_xref="EnsemblGenomes-Gn:BSU30490" /db_xref="EnsemblGenomes-Tr:CAB15027" /db_xref="GOA:O34614" /db_xref="InterPro:IPR010719" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG13909" /db_xref="UniProtKB/Swiss-Prot:O34614" /translation="MILKKILPYSKELLKMAAGEGDIVVDATMGNGHDTQFLAELVGE NGHVYAFDIQESAVANTKERLGDMYQARTTLFHKSHDKIAESLPPETHGKVAAAVFNL GYLPGGDKSITTNGSSTIKAIEQLLSIMKDEGLIVLVVYHGHPEGKAEKNDVLEFCRD LDQQTARVLTYGFINQQNDPPFIVAIEKKAQISK*" /label="ytqB CDS" gene 2772079..2772663 /gene="ytqB" /locus_tag="BSU_30490" /old_locus_tag="BSU30490" /label="ytqB gene" downshifts 2772627 /Source="Nicolas_upshifts" /id="D1570" /incds=0 /nref=58 /ntot=249 /MaxReadThrough="2.35311" /MaxDrop="4.47418" /score="22.0352465" /energy="-11.9" /TU="NA" /idTUdmin="U2362" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" CDS complement(2772653..2773756) /gene="tbcS" /locus_tag="BSU_30500" /old_locus_tag="BSU30500" /EC_number="4.2.3.130" /experiment="publication(s) with functional evidences, PMID:21627333, 24806199" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21627333, 24806199; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tetraprenyl-beta-curcumene synthase" /protein_id="NP_390928.1" /db_xref="EnsemblGenomes-Gn:BSU30500" /db_xref="EnsemblGenomes-Tr:CAB15028" /db_xref="GOA:O34707" /db_xref="InterPro:IPR019712" /db_xref="SubtiList:BG13901" /db_xref="UniProtKB/Swiss-Prot:O34707" /translation="MTVPEHPFGLMAKVYRDIFPLVHQELDIWKQKSESIHNSELKAQ ATASIRDKTFHCEGGGILALLSGSQKQKCVEFIIAYQTISDYLDNLCDRSTSLDPQDF RMLHASMQDALTVGAELQNYYQFREEQDDSGYLHELVKTCQRVLGSIEHYDMIKPYLL ELCGYYCDLQVHKHVIEHERVPRLEKWFTQYESELPEMEWYEFSACAGSTLGIFCLVA YSFQPDFTESTAKKIRDSYFPYIQGLHILLDYLIDQEEDLLEGDLNFCSYYQSHEEMM DRLEHFIHKADEHLQGIPHENFHRLINRGLLGVYLSDDKVAGQKEMGRLAKKLIKASG KTSLFFYINGRAYRKFQKMSWMKNSKKKAQIIC*" /label="tbcS CDS" gene complement(2772653..2773756) /gene="tbcS" /locus_tag="BSU_30500" /old_locus_tag="BSU30500" /label="tbcS gene" downshifts complement(2772694) /Source="Nicolas_upshifts" /id="D1571" /incds=0 /nref=35 /ntot=240 /MaxReadThrough="3.47268" /MaxDrop="4.45295" /score="16.7564664" /energy="-10.1" /TU="U2364" /idTUdmin="U2365" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" CDS complement(2773777..2774556) /gene="ytpA" /locus_tag="BSU_30510" /old_locus_tag="BSU30510" /EC_number="3.1.-.-" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:11796336" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11796336; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phospholipase component of bacilysocin synthesisor export" /protein_id="NP_390929.1" /db_xref="EnsemblGenomes-Gn:BSU30510" /db_xref="EnsemblGenomes-Tr:CAB15029" /db_xref="GOA:O34705" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR022742" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG13900" /db_xref="UniProtKB/Swiss-Prot:O34705" /translation="MWTWKADRPVAVIVIIHGASEYHGRYKWLIEMWRSSGYHVVMGD LPGQGTTTRARGHIRSFQEYIDEVDAWIDKARTFDLPVFLLGHSMGGLVAIEWVKQQR NPRITGIILSSPCLGLQIKVNKALDLASKGLNVIAPSLKVDSGLSIDMATRNEDVIEA DQNDSLYVRKVSVRWYRELLKTIESAMVPTEAFLKVPLLVMQAGDDKLVDKTMVIKWF NGVASHNKAYREWEGLYHEIFNEPEREDVFKAARAFTDQYI*" /label="ytpA CDS" gene complement(2773777..2774556) /gene="ytpA" /locus_tag="BSU_30510" /old_locus_tag="BSU30510" /label="ytpA gene" promotor_-35 2774199..2774206 /Source="Nicolas_upshift_promotors" /id="U2363" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.632367632367632" /psig="0.962037962037962" /xcortree=2858 /SigmaFactorBS="caagcgctttattcactttaaTTTGCAGTccgagacacggtg aTGATAAAATAATTCCCGTAAtccggggatttctttgctgtttaacccattcaatcgc g" /listShort="ytoA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2774221..2774240 /Source="Nicolas_upshift_promotors" /id="U2363" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.632367632367632" /psig="0.962037962037962" /xcortree=2858 /SigmaFactorBS="caagcgctttattcactttaaTTTGCAGTccgagacacggtg aTGATAAAATAATTCCCGTAAtccggggatttctttgctgtttaacccattcaatcgc g" /listShort="ytoA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2774238 /Source="Nicolas_upshifts" /id="U2363" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.632367632367632" /psig="0.962037962037962" /xcortree=2858 /SigmaFactorBS="caagcgctttattcactttaaTTTGCAGTccgagacacggtg aTGATAAAATAATTCCCGTAAtccggggatttctttgctgtttaacccattcaatcgc g" /listShort="ytoA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2774557..2775136) /Source="Nicolas_S_feature" /locus_tag="new_3123442_3124021_c" /HighExp="dia15, H2O2, Diami, Salt, dia5, M0t90, Lbstat, Etha, Paraq, Lbtran" /AntisenseName="ytoA" /AntisenseCor="-0.44861767737485803" /AntisenseRegPval="-14" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="SigA" /TUlongPSig=1 /label="S1163" CDS 2774605..2775120 /gene="ytoA" /locus_tag="BSU_30520" /old_locus_tag="BSU30520" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22868757; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme of the carbonic anhydrase family" /protein_id="NP_390930.1" /db_xref="EnsemblGenomes-Gn:BSU30520" /db_xref="EnsemblGenomes-Tr:CAB15030" /db_xref="GOA:O34696" /db_xref="InterPro:IPR001451" /db_xref="InterPro:IPR011004" /db_xref="SubtiList:BG13896" /db_xref="UniProtKB/Swiss-Prot:O34696" /translation="MIYPYKEHKPDIHPTAFIADNATITGDVVIGEQSSIWFSVVIRG DVAPTRIGNRVNIQDLSCLHQSPNKTLLIEDDATIGHQVTLHSAVIRKNALIGMGSII LDGAEIGEGAFIGAGSLVPPGKIIPPGHLAFGRPAKVIRPLTEEDRKDMQRIRSEYVE KGQYYKFLQQT*" /label="ytoA CDS" gene 2774605..2775120 /gene="ytoA" /locus_tag="BSU_30520" /old_locus_tag="BSU30520" /label="ytoA gene" promotor_-10 complement(2775127..2775146) /Source="Nicolas_upshift_promotors" /id="U2364" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.887112887112887" /psig=1 /xcortree=1919 /SigmaFactorBS="gtatgacgtccgggttaacgatggttattgcTTTCAAATata atttgaaaAATGGTAAAGTAAGACGAAGcaggtcttatgtttgttgaagaaatttata a" /listShort="S1163, ytpA, ytpB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2775136) /Source="Nicolas_upshifts" /id="U2364" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.887112887112887" /psig=1 /xcortree=1919 /SigmaFactorBS="gtatgacgtccgggttaacgatggttattgcTTTCAAATata atttgaaaAATGGTAAAGTAAGACGAAGcaggtcttatgtttgttgaagaaatttata a" /listShort="S1163, ytpA, ytpB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2775138..2775272) /Source="Nicolas_S_feature" /locus_tag="new_3124023_3124157_c" /HighExp="LoTm, Cold, dia5, dia15, Diami, H2O2, S7, G135, G180, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1164" promotor_-35 complement(2775158..2775165) /Source="Nicolas_upshift_promotors" /id="U2364" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.887112887112887" /psig=1 /xcortree=1919 /SigmaFactorBS="gtatgacgtccgggttaacgatggttattgcTTTCAAATata atttgaaaAATGGTAAAGTAAGACGAAGcaggtcttatgtttgttgaagaaatttata a" /listShort="S1163, ytpA, ytpB" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(2775247..2775266) /Source="Nicolas_upshift_promotors" /id="U2365" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.968031968031968" /psig="0.998001998001998" /xcortree=1850 /SigmaFactorBS="gtgctcatagaaaatagagaacaggaaagaataggtatgtgt ttttgcagaggctgtttatagtttTGTGATAAGATAAAAGTCATacgtttcatgctat a" /listShort="S1164, S1163, ytpA, ytpB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2775272) /Source="Nicolas_upshifts" /id="U2365" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.968031968031968" /psig="0.998001998001998" /xcortree=1850 /SigmaFactorBS="gtgctcatagaaaatagagaacaggaaagaataggtatgtgt ttttgcagaggctgtttatagtttTGTGATAAGATAAAAGTCATacgtttcatgctat a" /listShort="S1164, S1163, ytpA, ytpB" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2775365..2776756) /gene="ytnA" /locus_tag="BSU_30530" /old_locus_tag="BSU30530" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative amino acid permease" /protein_id="NP_390931.1" /db_xref="EnsemblGenomes-Gn:BSU30530" /db_xref="EnsemblGenomes-Tr:CAB15031" /db_xref="GOA:O34618" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG13891" /db_xref="UniProtKB/Swiss-Prot:O34618" /translation="MQKQKQELHRGLEERHISLMSLGAAIGVGLFLGSASAIQLAGPG ILVAYAASGLVMFFIMRALGEMAIQKPVAGSFSRYARDYLGPLAGYLTGWNYWFLWVV TCMAEITAVGIYMGFWFPDVPNWIWALSALVIMTGVNFLAVKAYGELEFWFALIKIVA ILSMIAVGLLMIIAGVGNGGIATGISNLWNNGGFFPHGLKGVLLSLQMVMFAYLGIEM IGVTAGEVKNPQKSLAKAIDTVFWRILIFYVGALFVIMSIYPWQEIGSQGSPFVLTFQ KVGIPSAAGIINFVVLTAALSSCNSGIFSTGRMLFNLAEQKEAPQAYGQLTKGGIPGK AVLASAGALLVGVLLNYVVPAKVFTWVTSIATFGAIWTWAIILLSQIKYRKSLKPEEK KQLKYKMPLFPFTSYVSLAFLAFVVILMAYSPDTRVAVIIGPIWFLILLAVYYGKGFH KKNAAAASERNIS*" /label="ytnA CDS" gene complement(2775365..2776756) /gene="ytnA" /locus_tag="BSU_30530" /old_locus_tag="BSU30530" /label="ytnA gene" downshifts complement(2775373) /Source="Nicolas_upshifts" /id="D1572" /incds=0 /nref=133 /ntot=225 /MaxReadThrough="3.05784" /MaxDrop="5.43778" /score="3.82664462" /energy="-7.5" /TU="U2368" /idTUdmin="U2368" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" S_feature complement(2776757..2776891) /Source="Nicolas_S_feature" /locus_tag="new_3125642_3125776_c" /HighExp="Oxctl, Paraq, Heat, Lbexp, G150, S0, dia0, H2O2, G180, Mal" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1165" CDS complement(2776892..2778790) /gene="asnB" /locus_tag="BSU_30540" /old_locus_tag="BSU30540" /EC_number="2.4.-.-" /EC_number="6.3.5.4" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10498721, 21949063, 28317238" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10498721, 21949063, 28317238; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="meso-diaminopimelic acid amidotransferase (asparagine synthetase)" /protein_id="NP_390932.1" /db_xref="EnsemblGenomes-Gn:BSU30540" /db_xref="EnsemblGenomes-Tr:CAB15032" /db_xref="GOA:P54420" /db_xref="InterPro:IPR001962" /db_xref="InterPro:IPR006426" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR017932" /db_xref="InterPro:IPR029055" /db_xref="InterPro:IPR033738" /db_xref="SubtiList:BG11831" /db_xref="UniProtKB/Swiss-Prot:P54420" /translation="MCGFVGVFNKHPLAQTADQEELIKQMNQMIVHRGPDSDGYFHDE HVGFGFRRLSIIDVENGGQPLSYEDETYWIIFNGEIYNYIELREELEAKGYTFNTDSD TEVLLATYRHYKEEAASKLRGMFAFLIWNKNDHVLYGARDPFGIKPLYYTTINDQVYF ASERKSLMVAQNDIEIDKEALQQYMSFQFVPEPSTLDAHVKKVEPGSQFTIRPDGDIT FKTYFKANFKPVQTEEDKLVKEVRDAIYDSVNVHMRSDVPVGSFLSGGIDSSFIVSVA KEFHPSLKTFSVGFEQQGFSEVDVAKETAAALGIENISKVISPEEYMNELPKIVWHFD DPLADPAAIPLYFVAKEAKKHVTVALSGEGADELFGGYNIYREPLSLKPFERIPSGLK KMLLHVAAVMPEGMRGKSLLERGCTPLQDRYIGNAKIFEESVKKQLLKHYNPNLSYRD VTKTYFTESSSYSDINKMQYVDIHTWMRGDILLKADKMTMANSLELRVPFLDKVVFDV ASKIPDELKTKNGTTKYLLRKAAEGIVPEHVLNRKKLGFPVPIRHWLKNEMNEWVRNI IQESQTDAYIHKDYVLQLLEDHCADKADNSRKIWTVLIFMIWHSINIEKRYMPEELSH QPKEVIFV*" /label="asnB CDS" gene complement(2776892..2778790) /gene="asnB" /locus_tag="BSU_30540" /old_locus_tag="BSU30540" /label="asnB gene" promotor_-35 2777948..2777954 /Source="Nicolas_upshift_promotors" /id="U2366" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=950 /SigmaFactorBS="aaagccgacagagaatgtttttaagctTGGATGAaattcctt cgcaacAGACACAATAAAggaagaatcaatcccgccagacaggaacgaaccgacagga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2777969..2777980 /Source="Nicolas_upshift_promotors" /id="U2366" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=950 /SigmaFactorBS="aaagccgacagagaatgtttttaagctTGGATGAaattcctt cgcaacAGACACAATAAAggaagaatcaatcccgccagacaggaacgaaccgacagga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2777981 /Source="Nicolas_upshifts" /id="U2366" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=950 /SigmaFactorBS="aaagccgacagagaatgtttttaagctTGGATGAaattcctt cgcaacAGACACAATAAAggaagaatcaatcccgccagacaggaacgaaccgacagga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2778791..2778914) /Source="Nicolas_S_feature" /locus_tag="new_3127676_3127799_c" /HighExp="Paraq, G135, G180, G150, Oxctl, LBGexp, BMM, dia0, Heat, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigA" /TUshortPSig="0.632, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1166" CDS complement(2778940..2780142) /gene="metK" /locus_tag="BSU_30550" /old_locus_tag="BSU30550" /EC_number="2.5.1.6" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8755891, 10094622, 12910260, 16672621, 18634909" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8755891, 10094622, 12910260, 16672621, 18634909; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="S-adenosylmethionine synthetase" /protein_id="NP_390933.1" /db_xref="EnsemblGenomes-Gn:BSU30550" /db_xref="EnsemblGenomes-Tr:CAB15033" /db_xref="GOA:P54419" /db_xref="InterPro:IPR002133" /db_xref="InterPro:IPR022628" /db_xref="InterPro:IPR022629" /db_xref="InterPro:IPR022630" /db_xref="InterPro:IPR022631" /db_xref="InterPro:IPR022636" /db_xref="SubtiList:BG11840" /db_xref="UniProtKB/Swiss-Prot:P54419" /translation="MSKNRRLFTSESVTEGHPDKICDQISDSILDEILKKDPNARVAC ETSVTTGLVLVSGEITTSTYVDIPKTVRQTIKEIGYTRAKYGFDAETCAVLTSIDEQS ADIAMGVDQALEAREGTMSDEEIEAIGAGDQGLMFGYACNETKELMPLPISLAHKLAR RLSEVRKEDILPYLRPDGKTQVTVEYDENNKPVRIDAIVISTQHHPEITLEQIQRNIK EHVINPVVPEELIDEETKYFINPTGRFVIGGPQGDAGLTGRKIIVDTYGGYARHGGGA FSGKDATKVDRSAAYAARYVAKNIVAAELADSCEVQLAYAIGVAQPVSISINTFGSGK ASEEKLIEVVRNNFDLRPAGIIKMLDLRRPIYKQTAAYGHFGRHDVDLPWERTDKAEQ LRKEALGE*" /label="metK CDS" gene complement(2778940..2780142) /gene="metK" /locus_tag="BSU_30550" /old_locus_tag="BSU30550" /label="metK gene" downshifts complement(2778959) /Source="Nicolas_upshifts" /id="D1573" /incds=0 /nref=2 /ntot=26 /MaxReadThrough="7.14538" /MaxDrop="3.78097" /score="-4.044113" /energy="-12.1" /TU="U2367,U2368" /idTUdmin="U2367" /TUdmin="-176" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2780185..2780196) /Source="Nicolas_upshift_promotors" /id="U2367" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.632367632367632" /psig="0.632367632367632" /xcortree=1447 /SigmaFactorBS="tatgccaattaacattctctaatataactgtacatTGTATAA gagggagcgagttCCGTATCATATAtacaaggtctttcgggaggccttgtgcaggagg a" /listShort="metK, S1166" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2780191) /Source="Nicolas_upshifts" /id="U2367" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.632367632367632" /psig="0.632367632367632" /xcortree=1447 /SigmaFactorBS="tatgccaattaacattctctaatataactgtacatTGTATAA gagggagcgagttCCGTATCATATAtacaaggtctttcgggaggccttgtgcaggagg a" /listShort="metK, S1166" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2780193..2780309) /Source="Nicolas_S_feature" /locus_tag="new_3129078_3129194_c" /HighExp="G180, Paraq, G150, Oxctl, G135, BMM, LBGexp, HPh, MG-0.2, GM 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1167" promotor_-35 complement(2780210..2780216) /Source="Nicolas_upshift_promotors" /id="U2367" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.632367632367632" /psig="0.632367632367632" /xcortree=1447 /SigmaFactorBS="tatgccaattaacattctctaatataactgtacatTGTATAA gagggagcgagttCCGTATCATATAtacaaggtctttcgggaggccttgtgcaggagg a" /listShort="metK, S1166" /GFF_Attribute="listLong" /label="promotor_-35" misc_RNA complement(2780310..2780448) /gene="mswG" /locus_tag="BSU_misc_RNA_50" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762; Product type n: RNA" /function="16.3: Control" /label="mswG RNA" gene complement(2780310..2780448) /gene="mswG" /locus_tag="BSU_misc_RNA_50" /label="mswG gene" downshifts 2780408 /Source="Nicolas_upshifts" /id="D1574" /incds=0 /nref=3 /ntot=20 /MaxReadThrough="1.15866" /MaxDrop="4.97875" /score="11.8729615" /energy="-16.6" /TU="NA" /idTUdmin="U2369" /TUdmin="-1841" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2780457..2780476) /Source="Nicolas_upshift_promotors" /id="U2368" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.624375624375624" /psig=1 /xcortree=2593 /SigmaFactorBS="ttccctcaatataggtgcctatttcttctgaatcaTATTGac attgcaaaccctttTACGATAAGATATTTCATTGagcggatactcttatcccgagctg g" /listShort="NA, S1167, metK, S1166, asnB, S1165, ytnA, S1164" /listLong="S1163, ytpA, ytpB" /label="promotor_-10" upshifts complement(2780472) /Source="Nicolas_upshifts" /id="U2368" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.624375624375624" /psig=1 /xcortree=2593 /SigmaFactorBS="ttccctcaatataggtgcctatttcttctgaatcaTATTGac attgcaaaccctttTACGATAAGATATTTCATTGagcggatactcttatcccgagctg g" /listShort="NA, S1167, metK, S1166, asnB, S1165, ytnA, S1164" /listLong="S1163, ytpA, ytpB" /label="upshifts" promotor_-35 complement(2780493..2780497) /Source="Nicolas_upshift_promotors" /id="U2368" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.624375624375624" /psig=1 /xcortree=2593 /SigmaFactorBS="ttccctcaatataggtgcctatttcttctgaatcaTATTGac attgcaaaccctttTACGATAAGATATTTCATTGagcggatactcttatcccgagctg g" /listShort="NA, S1167, metK, S1166, asnB, S1165, ytnA, S1164" /listLong="S1163, ytpA, ytpB" /label="promotor_-35" promotor_-35 2780569..2780576 /Source="Nicolas_upshift_promotors" /id="U2369" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.817182817182817" /psig=1 /xcortree=345 /SigmaFactorBS="gggaaaacaatggaaatgcacacacaaaaaacaataaatagT ATAGACTatttgaaaatataTGTTATACTAATTCACAATTagcaaaacacaaaaaacg a" /listShort="pckA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2780588 /Source="Nicolas_upshifts" /id="U2369" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.817182817182817" /psig=1 /xcortree=345 /SigmaFactorBS="gggaaaacaatggaaatgcacacacaaaaaacaataaatagT ATAGACTatttgaaaatataTGTTATACTAATTCACAATTagcaaaacacaaaaaacg a" /listShort="pckA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2780590..2780609 /Source="Nicolas_upshift_promotors" /id="U2369" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.817182817182817" /psig=1 /xcortree=345 /SigmaFactorBS="gggaaaacaatggaaatgcacacacaaaaaacaataaatagT ATAGACTatttgaaaatataTGTTATACTAATTCACAATTagcaaaacacaaaaaacg a" /listShort="pckA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2780645..2782228 /gene="pckA" /locus_tag="BSU_30560" /old_locus_tag="BSU30560" /EC_number="4.1.1.49" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1400158, 4146915, 15491857, 15720552, 18586936, 20933603, 23136871; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoenolpyruvate carboxykinase" /protein_id="NP_390934.2" /db_xref="EnsemblGenomes-Gn:BSU30560" /db_xref="EnsemblGenomes-Tr:CAB15034" /db_xref="GOA:P54418" /db_xref="InterPro:IPR001272" /db_xref="InterPro:IPR008210" /db_xref="InterPro:IPR013035" /db_xref="InterPro:IPR015994" /db_xref="SubtiList:BG11841" /db_xref="UniProtKB/Swiss-Prot:P54418" /translation="MNSVDLTADLQALLTCPNVRHNLSAAQLTEKVLSRNEGILTSTG AVRATTGAYTGRSPKDKFIVEEESTKNKIDWGPVNQPISEEAFERLYTKVVSYLKERD ELFVFEGFAGADEKYRLPITVVNEFAWHNLFARQLFIRPEGNDKKTVEQPFTILSAPH FKADPKTDGTHSETFIIVSFEKRTILIGGTEYAGEMKKSIFSIMNFLLPERDILSMHC SANVGEKGDVALFFGLSGTGKTTLSADADRKLIGDDEHGWSDTGVFNIEGGCYAKCIH LSEEKEPQIFNAIRFGSVLENVVVDEDTREANYDDSFYTENTRAAYPIHMINNIVTPS MAGHPSAIVFLTADAFGVLPPISKLTKEQAMYHFLSGYTSKLAGTERGVTSPETTFST CFGSPFLPLPAHVYAEMLGKKIDEHGADVFLVNTGWTGGGYGTGERMKLSYTRAMVKA AIEGKLEDAEMITDDIFGLHIPAHVPGVPDHILQPENTWTNKEEYKEKAVYLANEFKE NFKKFAHTDAIAQAGGPLV*" /label="pckA CDS" gene 2780645..2782228 /gene="pckA" /locus_tag="BSU_30560" /old_locus_tag="BSU30560" /label="pckA gene" downshifts 2782217 /Source="Nicolas_upshifts" /id="D1575" /incds=0 /nref=106 /ntot=269 /MaxReadThrough="2.55056" /MaxDrop="8.3695" /score="11.8729615" /energy="-16.6" /TU="U2369" /idTUdmin="U2369" /TUdmin="-32" /isTUend="FALSE" /label="downshifts" CDS complement(2782267..2782509) /gene="ytmB" /locus_tag="BSU_30570" /old_locus_tag="BSU30570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390935.1" /db_xref="EnsemblGenomes-Gn:BSU30570" /db_xref="EnsemblGenomes-Tr:CAB15035" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR019699" /db_xref="PDB:2NWA" /db_xref="SubtiList:BG13882" /db_xref="UniProtKB/Swiss-Prot:O34365" /translation="MGMPVEFNTLIVTKGKEVRIDENIFTLEKDGYRVYPMEIPMDVR KTKFGEKSGTAEVQKLQWEEGRTIITYKLTSLHSVN*" /label="ytmB CDS" gene complement(2782267..2782509) /gene="ytmB" /locus_tag="BSU_30570" /old_locus_tag="BSU30570" /label="ytmB gene" downshifts complement(2782281) /Source="Nicolas_upshifts" /id="D1576" /incds=0 /nref=170 /ntot=242 /MaxReadThrough="1.2088" /MaxDrop="5.1365" /score="38.3436505" /energy="-16.6" /TU="NA" /idTUdmin="U2371" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2782561..2783334) /gene="ytmA" /locus_tag="BSU_30580" /old_locus_tag="BSU30580" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 27899916; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative esterase" /protein_id="NP_390936.1" /db_xref="EnsemblGenomes-Gn:BSU30580" /db_xref="EnsemblGenomes-Tr:CAB15036" /db_xref="GOA:O34493" /db_xref="InterPro:IPR001375" /db_xref="InterPro:IPR002471" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG13881" /db_xref="UniProtKB/Swiss-Prot:O34493" /translation="MIVEKRRFPSPSQHVRLYTICYLSNGLRVKGLLAEPAEPGQYDG FLYLRGGIKSVGMVRPGRIIQFASQGFVVFAPFYRGNQGGEGNEDFAGEDREDAFSAF RLLQQHPNVKKDRIHIFGFSRGGIMGMLTAIEMGGQAASFVSWGGVSDMILTYEERQD LRRMMKRVIGGTPKKVPEEYQWRTPFDQVNKIQAPVLLIHGEKDQNVSIQHSYLLEEK LKQLHKPVETWYYSTFTHYFPPKENRRIVRQLTQWMKNR*" /label="ytmA CDS" gene complement(2782561..2783334) /gene="ytmA" /locus_tag="BSU_30580" /old_locus_tag="BSU30580" /label="ytmA gene" S_feature complement(2783335..2783425) /Source="Nicolas_S_feature" /locus_tag="new_3132220_3132310_c" /HighExp="S8, dia15, Diami, Etha, S7, dia5, H2O2, G180, Heat, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1168" promotor_-35 2783401..2783410 /Source="Nicolas_upshift_promotors" /id="U2370" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1294 /SigmaFactorBS="tttccttactccaaaattacatccggagaacctggttagGCA TTCACACatttttatacccATCATACGATATGTAAAGCAaaaaaggatattaacttga t" /listShort="ytlA, ytlC, ytlD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2783414..2783433) /Source="Nicolas_upshift_promotors" /id="U2371" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.79020979020979" /psig="0.996003996003996" /xcortree=2027 /SigmaFactorBS="cacatagacaacctccttatttcgcatcaagtTAATATCCtt ttttgctttacaTATCGTATGATGGGTATAAAaatgtgtgaatgcctaaccaggttct c" /listShort="S1168, ytmA, ytmB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2783422 /Source="Nicolas_upshifts" /id="U2370" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1294 /SigmaFactorBS="tttccttactccaaaattacatccggagaacctggttagGCA TTCACACatttttatacccATCATACGATATGTAAAGCAaaaaaggatattaacttga t" /listShort="ytlA, ytlC, ytlD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2783423..2783442 /Source="Nicolas_upshift_promotors" /id="U2370" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1294 /SigmaFactorBS="tttccttactccaaaattacatccggagaacctggttagGCA TTCACACatttttatacccATCATACGATATGTAAAGCAaaaaaggatattaacttga t" /listShort="ytlA, ytlC, ytlD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2783427) /Source="Nicolas_upshifts" /id="U2371" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.79020979020979" /psig="0.996003996003996" /xcortree=2027 /SigmaFactorBS="cacatagacaacctccttatttcgcatcaagtTAATATCCtt ttttgctttacaTATCGTATGATGGGTATAAAaatgtgtgaatgcctaaccaggttct c" /listShort="S1168, ytmA, ytmB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2783448..2783455) /Source="Nicolas_upshift_promotors" /id="U2371" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.79020979020979" /psig="0.996003996003996" /xcortree=2027 /SigmaFactorBS="cacatagacaacctccttatttcgcatcaagtTAATATCCtt ttttgctttacaTATCGTATGATGGGTATAAAaatgtgtgaatgcctaaccaggttct c" /listShort="S1168, ytmA, ytmB" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2783485..2784489 /gene="ytlA" /locus_tag="BSU_30595" /old_locus_tag="BSU30595" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC anion transporter component" /protein_id="NP_390937.2" /db_xref="EnsemblGenomes-Gn:BSU30595" /db_xref="EnsemblGenomes-Tr:CAB15037" /db_xref="GOA:C0SP84" /db_xref="SubtiList:BG13873" /db_xref="UniProtKB/Swiss-Prot:C0SP84" /translation="MNRWLRLGFACVGSIFLMFALAACKQEETLTKVKVAEVTHSIFY APLYVAESKGFFKEEGLDVDVNTTWGGDKTMTSLLSNGSDIALVGSETSIYVEAQGAK DPVINFAQLTQTDGTFLVAREDVEHFDWDQLKGKTFLGQRKGGMPQMVGEYVLNKHKI DPHKDIDLIQNIDFANIANAFASGTGEYVQLFEPQASLFEKKGIGHIVASFGEESGEV PYTTFMAKQSYLKKNEDTAVKFTKAIYKAQQWVENHSAKDITDAIKDEFDDTDPDVIE TSIERYKKQHSYSPDPLLNEKEWELLQTIMDKSGELPKHIPYNQLVNKEIAEKVTSEK *" /label="ytlA CDS" gene 2783485..2784489 /gene="ytlA" /locus_tag="BSU_30595" /old_locus_tag="BSU30595" /label="ytlA gene" CDS 2784502..2785284 /gene="ytlC" /locus_tag="BSU_30610" /old_locus_tag="BSU30610" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC anion transporter component, ATP-binding" /protein_id="NP_390939.1" /db_xref="EnsemblGenomes-Gn:BSU30610" /db_xref="EnsemblGenomes-Tr:CAB15039" /db_xref="GOA:O34314" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13875" /db_xref="UniProtKB/Swiss-Prot:O34314" /translation="MSFLHVDHVTHTYFSIKEKTTAVRDIHFDAEKGDFISFLGPSGC GKTTLLSIIAGLIEPSEGRVLIEGREPNQKEHNIGYMLQQDYLFPWKSIEENVLLGLK IADTLTEESKAAALGLLPEFGLIDVEKKYPKELSGGMRQRAALARTLAPNPSLLLLDE PFSALDFQTKLSLENLVFRTLKEYQKTAVLVTHDIGEAIAMSDTIFLFSNQPGTIHQI FTIPKELAAMLPFDARQEPSFQTLFQTIWKELNSLEKQQRNH*" /label="ytlC CDS" gene 2784502..2785284 /gene="ytlC" /locus_tag="BSU_30610" /old_locus_tag="BSU30610" /label="ytlC gene" S_feature complement(2784506..2786054) /Source="Nicolas_S_feature" /locus_tag="new_3133391_3134939_c" /HighExp="Cold, S8, G180, H2O2, G135, Paraq, G150, S7, Oxctl, LPh" /AntisenseName="ytlC" /AntisenseCor="0.110169300738282" /AntisenseRegPval="-1.1000000000000001" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1169" CDS 2785259..2786071 /gene="ytlD" /locus_tag="BSU_30620" /old_locus_tag="BSU30620" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease of ABC anion transporter" /protein_id="NP_390940.1" /db_xref="EnsemblGenomes-Gn:BSU30620" /db_xref="EnsemblGenomes-Tr:CAB15040" /db_xref="GOA:O34649" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG13876" /db_xref="UniProtKB/Swiss-Prot:O34649" /translation="MRNSKETIDLLHEQYQFKQKKEKWKVHSFQLAIFILFFSGWEIS SRQGWIDPLIFSSPSAVWRLLLEKLGDGSLLSHIGVTLFETVLGFLLGTFMGTCLAAL LWWSNRLARILDPYLVILNAMPKVALGPILIVALGPSFISIIAMGAIISVIITTIVVY TAFQEVDENYTKVMKTFGAKKWVIFKEVILPASSPAIISTLKVNVGLSWVGVIVGEFL VSKVGLGYMIIYGFQVFNFTLVFLSLLIIAIFATLMYQGVELLEKKWTKGRT*" /label="ytlD CDS" gene 2785259..2786071 /gene="ytlD" /locus_tag="BSU_30620" /old_locus_tag="BSU30620" /label="ytlD gene" downshifts 2786056 /Source="Nicolas_upshifts" /id="D1577" /incds=0 /nref=1 /ntot=31 /MaxReadThrough="3.58734" /MaxDrop="4.596" /score="38.1379668" /energy="-12.6" /TU="U2370" /idTUdmin="U2370" /TUdmin="-242" /isTUend="FALSE" /label="downshifts" CDS complement(2786098..2786574) /gene="rppG" /locus_tag="BSU_30630" /old_locus_tag="BSU30630" /EC_number="3.6.1.15" /function="16.6: Maintain" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15576788, 16513759, 21925382, 23610407, 23610425, 27936487" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15576788, 16513759, 21925382, 23610407, 23610425, 27936487; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="nucleoside and RNA triphosphate phosphohydrolase" /protein_id="NP_390941.1" /db_xref="EnsemblGenomes-Gn:BSU30630" /db_xref="EnsemblGenomes-Tr:CAB15041" /db_xref="GOA:O35013" /db_xref="InterPro:IPR000086" /db_xref="InterPro:IPR014078" /db_xref="InterPro:IPR015797" /db_xref="InterPro:IPR020084" /db_xref="InterPro:IPR020476" /db_xref="PDB:4JZS" /db_xref="PDB:4JZT" /db_xref="PDB:4JZU" /db_xref="PDB:4JZV" /db_xref="SubtiList:BG13869" /db_xref="UniProtKB/Swiss-Prot:O35013" /translation="MYEFKDYYQNTVQLSFDDQPFSDSPKHVWVICRFGGKWLLTEHE DRGYEFPGGKVEPMECAEEAALREVKEETGARVKSLKYLGQYKVLGKEKVIVKNIYFA DIEKLEKQADYFETKGPVLFHELPENLSRNKKFSFIMKDSVLPISLKKLKESGWIE*" /label="rppG CDS" gene complement(2786098..2786574) /gene="rppG" /locus_tag="BSU_30630" /old_locus_tag="BSU30630" /label="rppG gene" downshifts complement(2786099) /Source="Nicolas_upshifts" /id="D1578" /incds=0 /nref=171 /ntot=265 /MaxReadThrough="4.52721" /MaxDrop="6.99686" /score="36.2618206" /energy="-12.6" /TU="U2372" /idTUdmin="U2373" /TUdmin=11 /isTUend="TRUE" /label="downshifts" misc_feature complement(2786604..2786623) /Source="Nicolas_upshift_promotors" /id="U2372" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.935064935064935" /psig=1 /xcortree=2134 /SigmaFactorBS="cggcgtgctgggtttcccttattttttgataaaaggcttccg aagaaacgtaacTGTGGTATGATGTATGGAAGatagctaggaacggatttgagggata a" /listShort="ytkD, S1169" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2786617) /Source="Nicolas_upshifts" /id="U2372" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.935064935064935" /psig=1 /xcortree=2134 /SigmaFactorBS="cggcgtgctgggtttcccttattttttgataaaaggcttccg aagaaacgtaacTGTGGTATGATGTATGGAAGatagctaggaacggatttgagggata a" /listShort="ytkD, S1169" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2786619..2786753) /Source="Nicolas_S_feature" /locus_tag="new_3135504_3135638_c" /HighExp="BT, B36, S8, S5, S7, Etha, S6, S4, B60, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigK, SigB" /TUshortPSig="0.909, 1, 0.994" /TUlongSig="SigA, SigA" /TUlongPSig="0.999, 0.994" /label="S1170" upshifts complement(2786753) /Source="Nicolas_upshifts" /id="U2373" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.909090909090909" /psig="0.909090909090909" /xcortree=1213 /SigmaFactorBS="gttaaaaaataaatttaagcgcaaacCGTAACTtttccctgt tcgcgGGTCATAATAAAgcccagagcgtcggtcgcactttccggcaaaagtatcgcaa a" /listShort="S1170, ytkD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2786755..2786766) /Source="Nicolas_upshift_promotors" /id="U2373" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.909090909090909" /psig="0.909090909090909" /xcortree=1213 /SigmaFactorBS="gttaaaaaataaatttaagcgcaaacCGTAACTtttccctgt tcgcgGGTCATAATAAAgcccagagcgtcggtcgcactttccggcaaaagtatcgcaa a" /listShort="S1170, ytkD" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2786781..2786787) /Source="Nicolas_upshift_promotors" /id="U2373" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.909090909090909" /psig="0.909090909090909" /xcortree=1213 /SigmaFactorBS="gttaaaaaataaatttaagcgcaaacCGTAACTtttccctgt tcgcgGGTCATAATAAAgcccagagcgtcggtcgcactttccggcaaaagtatcgcaa a" /listShort="S1170, ytkD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2786783..2787187) /gene="ytkC" /locus_tag="BSU_30640" /old_locus_tag="BSU30640" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type h: extrachromosomal origin" /codon_start=1 /transl_table=11 /product="putative autolytic amidase" /protein_id="NP_390942.1" /db_xref="EnsemblGenomes-Gn:BSU30640" /db_xref="EnsemblGenomes-Tr:CAB15042" /db_xref="GOA:O34883" /db_xref="InterPro:IPR006480" /db_xref="SubtiList:BG13868" /db_xref="UniProtKB/Swiss-Prot:O34883" /translation="MDRDFGIFSFLAVSVSAAGFFFGGFQYSFLILLSLMAIEFISTT LKETIIHKLSFKKVFARLVKKLVTLALISVCHFFDQLLNTQGSIRDLAIMFYILYESV QIVVTASSLGIPVPQMLVDLLETLKNKFKRKP*" /label="ytkC CDS" gene complement(2786783..2787187) /gene="ytkC" /locus_tag="BSU_30640" /old_locus_tag="BSU30640" /label="ytkC gene" promotor_-10 complement(2787215..2787234) /Source="Nicolas_upshift_promotors" /id="U2374" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1424 /SigmaFactorBS="gaaaaataggcgacaaccagtccatttttctgaaaaATCCAA TCCGttcggcttgtttACCATAGAATATCGTAAGGCcgtttctgtgaaaggatgttgg g" /listShort="ytkC, S1170, ytkD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2787232) /Source="Nicolas_upshifts" /id="U2374" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1424 /SigmaFactorBS="gaaaaataggcgacaaccagtccatttttctgaaaaATCCAA TCCGttcggcttgtttACCATAGAATATCGTAAGGCcgtttctgtgaaaggatgttgg g" /listShort="ytkC, S1170, ytkD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2787234..2787320) /Source="Nicolas_S_feature" /locus_tag="new_3136119_3136205_c" /HighExp="Etha, B36, S8, B60, S7, LoTm, Salt, Sw, Gly, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.994" /TUlongSig="SigA, SigA" /TUlongPSig="0.999, 0.994" /label="S1171" promotor_-35 complement(2787247..2787256) /Source="Nicolas_upshift_promotors" /id="U2374" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1424 /SigmaFactorBS="gaaaaataggcgacaaccagtccatttttctgaaaaATCCAA TCCGttcggcttgtttACCATAGAATATCGTAAGGCcgtttctgtgaaaggatgttgg g" /listShort="ytkC, S1170, ytkD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2787353..2787790) /gene="dps" /locus_tag="BSU_30650" /old_locus_tag="BSU30650" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 12767829, 16091047, 16861227, 16935006; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="DNA-protecting protein, mini-ferritin" /protein_id="NP_390943.1" /db_xref="EnsemblGenomes-Gn:BSU30650" /db_xref="EnsemblGenomes-Tr:CAB15043" /db_xref="GOA:P80879" /db_xref="InterPro:IPR002177" /db_xref="InterPro:IPR008331" /db_xref="InterPro:IPR009078" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR023188" /db_xref="SubtiList:BG12584" /db_xref="UniProtKB/Swiss-Prot:P80879" /translation="MSEQLIQAVNKQVANWTVMYVKLHNYHWYVKGKDFFTLHEKFEE LYNETATYIDDLAERLLALNGKPIATMKESLETASVKEAAGNETAEQMVQSVYDDFTV IAEELKNGMDLADEVGDETTGDMLLAIHQNIEKHNWMLKAYLG*" /label="dps CDS" gene complement(2787353..2787790) /gene="dps" /locus_tag="BSU_30650" /old_locus_tag="BSU30650" /label="dps gene" downshifts complement(2787365) /Source="Nicolas_upshifts" /id="D1579" /incds=0 /nref=188 /ntot=382 /MaxReadThrough="3.87056" /MaxDrop="7.83664" /score="36.0931083" /energy="-19.2" /TU="U2375" /idTUdmin="U2377" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2787807..2787825) /Source="Nicolas_upshift_promotors" /id="U2375" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=143 /SigmaFactorBS="cataatagaagaaatcgtgacagataagggtaaaaaagaGGT TTTAgcgtacgatattaaGGGTATACATAGTCATATAacaaggaggagataccatgtc a" /listShort="dps, S1171, ytkC, S1170, ytkD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2787825) /Source="Nicolas_upshifts" /id="U2375" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=143 /SigmaFactorBS="cataatagaagaaatcgtgacagataagggtaaaaaagaGGT TTTAgcgtacgatattaaGGGTATACATAGTCATATAacaaggaggagataccatgtc a" /listShort="dps, S1171, ytkC, S1170, ytkD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2787827..2788052) /Source="Nicolas_S_feature" /locus_tag="new_3136712_3136937_c" /HighExp="M0t90, Lbstat, M40t90, ferm, S2, nit, M40t45, S0, Lbtran, BT" /AntisenseName="ytzI" /AntisenseCor="-0.30531150128448598" /AntisenseRegPval="-6.5" /CDS_PredictionProba="0.38276900000000003" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.999, 0.999, 0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S1172" promotor_-35 complement(2787840..2787846) /Source="Nicolas_upshift_promotors" /id="U2375" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=143 /SigmaFactorBS="cataatagaagaaatcgtgacagataagggtaaaaaagaGGT TTTAgcgtacgatattaaGGGTATACATAGTCATATAacaaggaggagataccatgtc a" /listShort="dps, S1171, ytkC, S1170, ytkD" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 2787882..2787901 /Source="Nicolas_upshift_promotors" /id="U2376" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.94005994005994" /psig="0.999000999001" /xcortree=436 /SigmaFactorBS="ccttaatatcgtacgctaaaacctcttttttacccttatctg tcacgatttcttctatTATGCTACAATTGTTAAAAAacgggaggtggaatgtcatgac g" /listShort="ytzI" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 2787883..2788059 /gene="ytzI" /locus_tag="BSU_30659" /old_locus_tag="BSU30659" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097774.1" /db_xref="EnsemblGenomes-Gn:BSU30659" /db_xref="EnsemblGenomes-Tr:CAX52680" /db_xref="GOA:C0H3Q1" /db_xref="InterPro:IPR022248" /db_xref="UniProtKB/Swiss-Prot:C0H3Q1" /translation="MLQLLKNGRWNVMTLLITISILIVLAVLLVTIWTTVKAYNVKHT IDPPQENHSDSHNQ*" /label="ytzI CDS" gene 2787883..2788059 /gene="ytzI" /locus_tag="BSU_30659" /old_locus_tag="BSU30659" /label="ytzI gene" upshifts 2787884 /Source="Nicolas_upshifts" /id="U2376" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.94005994005994" /psig="0.999000999001" /xcortree=436 /SigmaFactorBS="ccttaatatcgtacgctaaaacctcttttttacccttatctg tcacgatttcttctatTATGCTACAATTGTTAAAAAacgggaggtggaatgtcatgac g" /listShort="ytzI" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2788053..2788490) /gene="ytkA" /locus_tag="BSU_30660" /old_locus_tag="BSU30660" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_390944.1" /db_xref="EnsemblGenomes-Gn:BSU30660" /db_xref="EnsemblGenomes-Tr:CAB15044" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR032693" /db_xref="SubtiList:BG11027" /db_xref="UniProtKB/Swiss-Prot:P40768" /translation="MKKMLVVLLFSALLLNGCGSGESKANTAETPEVLDVKLTGPEKV NPGESAAYEAAVSYGDEAVTDADEVEFEVWKEGEKDASQMFKVKQEKGVYRLETTFKE DGVYTVQSHVTAKKQHSMPTLKVQVGDADAASNQSEEEHSHHH*" /label="ytkA CDS" gene complement(2788053..2788490) /gene="ytkA" /locus_tag="BSU_30660" /old_locus_tag="BSU30660" /label="ytkA gene" downshifts 2788079 /Source="Nicolas_upshifts" /id="D1580" /incds=0 /nref=37 /ntot=155 /MaxReadThrough="2.0116" /MaxDrop="3.95427" /score="13.1411485" /energy="-20.5" /TU="NA" /idTUdmin="U2376" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2788509..2788528) /Source="Nicolas_upshift_promotors" /id="U2377" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.892107892107892" /psig="0.999000999001" /xcortree=1608 /SigmaFactorBS="cgcttaagcaaaaaggtcttttttgtgacgtctcatattttg tGTACCATTTgctgtaagcgTTTGCTACTATTTAGGTAAAcgatgaaagggtgatggc a" /listShort="ytkA, S1172, dps" /listLong="S1171, ytkC, S1170, ytkD" /label="promotor_-10" upshifts complement(2788530) /Source="Nicolas_upshifts" /id="U2377" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.892107892107892" /psig="0.999000999001" /xcortree=1608 /SigmaFactorBS="cgcttaagcaaaaaggtcttttttgtgacgtctcatattttg tGTACCATTTgctgtaagcgTTTGCTACTATTTAGGTAAAcgatgaaagggtgatggc a" /listShort="ytkA, S1172, dps" /listLong="S1171, ytkC, S1170, ytkD" /label="upshifts" promotor_-35 complement(2788539..2788547) /Source="Nicolas_upshift_promotors" /id="U2377" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.892107892107892" /psig="0.999000999001" /xcortree=1608 /SigmaFactorBS="cgcttaagcaaaaaggtcttttttgtgacgtctcatattttg tGTACCATTTgctgtaagcgTTTGCTACTATTTAGGTAAAcgatgaaagggtgatggc a" /listShort="ytkA, S1172, dps" /listLong="S1171, ytkC, S1170, ytkD" /label="promotor_-35" CDS complement(2788610..2789083) /gene="luxS" /locus_tag="BSU_30670" /old_locus_tag="BSU30670" /EC_number="4.4.1.21" /function="16.5: Explore" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11601850, 15287744, 15751951, 16740951, 17056751, 22720735, 22938038, 26779171, 28342077" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11601850, 15287744, 15751951, 16740951, 17056751, 22720735, 22938038, 26779171, 28342077; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="S-ribosylhomocysteine lyase" /protein_id="NP_390945.1" /db_xref="EnsemblGenomes-Gn:BSU30670" /db_xref="EnsemblGenomes-Tr:CAB15045" /db_xref="GOA:O34667" /db_xref="InterPro:IPR003815" /db_xref="InterPro:IPR011249" /db_xref="InterPro:IPR037005" /db_xref="PDB:1IE0" /db_xref="PDB:1J98" /db_xref="PDB:1JQW" /db_xref="PDB:1JVI" /db_xref="PDB:1YCL" /db_xref="PDB:2FQO" /db_xref="PDB:2FQT" /db_xref="SubtiList:BG13866" /db_xref="UniProtKB/Swiss-Prot:O34667" /translation="MPSVESFELDHNAVVAPYVRHCGVHKVGTDGVVNKFDIRFCQPN KQAMKPDTIHTLEHLLAFTIRSHAEKYDHFDIIDISPMGCQTGYYLVVSGEPTSAEIV DLLEDTMKEAVEITEIPAANEKQCGQAKLHDLEGAKRLMRFWLSQDKEELLKVFG*" /label="luxS CDS" gene complement(2788610..2789083) /gene="luxS" /locus_tag="BSU_30670" /old_locus_tag="BSU30670" /label="luxS gene" downshifts complement(2788619) /Source="Nicolas_upshifts" /id="D1581" /incds=0 /nref=72 /ntot=201 /MaxReadThrough="4.53626" /MaxDrop="4.63695" /score="14.8438415" /energy="-14.2" /TU="U2379,U2380" /idTUdmin="U2380" /TUdmin="-793" /isTUend="FALSE" /label="downshifts" downshifts complement(2788706) /Source="Nicolas_upshifts" /id="D1582" /incds=1 /nref=1 /ntot=96 /MaxReadThrough="5.57623" /MaxDrop="2.4806" /score="14.8438415" /energy="-14.2" /TU="U2379,U2380" /idTUdmin="U2380" /TUdmin="-880" /isTUend="FALSE" /label="downshifts" S_feature complement(2789084..2789435) /Source="Nicolas_S_feature" /locus_tag="new_3137969_3138320_c" /HighExp="Etha, B36, B60, BMM, S2, Heat, S1, LoTm, Lbtran, S5" /AntisenseName="ytjA" /AntisenseCor="-0.45038987072908898" /AntisenseRegPval="-14.1" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S1173" promotor_-35 2789155..2789162 /Source="Nicolas_upshift_promotors" /id="U2378" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.553446553446553" /psig="0.999000999001" /xcortree=2863 /SigmaFactorBS="ttataacatacttttccgataagaattattgattaACTTTTC AatctgtgtttttTTTCTTATACTTGCATCAGAaaggttgctgaagaaacatgaaaac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2789175..2789194 /Source="Nicolas_upshift_promotors" /id="U2378" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.553446553446553" /psig="0.999000999001" /xcortree=2863 /SigmaFactorBS="ttataacatacttttccgataagaattattgattaACTTTTC AatctgtgtttttTTTCTTATACTTGCATCAGAaaggttgctgaagaaacatgaaaac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2789180 /Source="Nicolas_upshifts" /id="U2378" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.553446553446553" /psig="0.999000999001" /xcortree=2863 /SigmaFactorBS="ttataacatacttttccgataagaattattgattaACTTTTC AatctgtgtttttTTTCTTATACTTGCATCAGAaaggttgctgaagaaacatgaaaac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 2789212..2789439 /gene="ytjA" /locus_tag="BSU_30680" /old_locus_tag="BSU30680" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 19306042, 21803992; Product type f: factor" /codon_start=1 /transl_table=11 /product="membrane protein insertion efficiency factor" /protein_id="NP_390946.1" /db_xref="EnsemblGenomes-Gn:BSU30680" /db_xref="EnsemblGenomes-Tr:CAB15046" /db_xref="GOA:O34601" /db_xref="InterPro:IPR002696" /db_xref="SubtiList:BG13865" /db_xref="UniProtKB/Swiss-Prot:O34601" /translation="MKTLFIALIRGYQKFISPLTPPTCRFYPTCSQYGIEAIKTHGAL KGGWLTIKRILKCHPFHPGGVDPVPEKKQKH*" /label="ytjA CDS" gene 2789212..2789439 /gene="ytjA" /locus_tag="BSU_30680" /old_locus_tag="BSU30680" /label="ytjA gene" CDS complement(2789436..2789999) /gene="ytiB" /locus_tag="BSU_30690" /old_locus_tag="BSU30690" /EC_number="4.2.1.1" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12193617, 21266987; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="carbonic anhydrase" /protein_id="NP_390947.1" /db_xref="EnsemblGenomes-Gn:BSU30690" /db_xref="EnsemblGenomes-Tr:CAB15047" /db_xref="GOA:O34872" /db_xref="InterPro:IPR001765" /db_xref="InterPro:IPR036874" /db_xref="SubtiList:BG13863" /db_xref="UniProtKB/Swiss-Prot:O34872" /translation="MSLLNDILEFNKTFTEQREYEKYQTSKFPDKKMAILSCMDTRLV ELLPHAMNLRNGDVKIIKSAGALVTHPFGSIMRSILVAVYELNADEVCVIGHHDCGMS KISSKSMLEKIKARGIPEERIETIKYSGVDFDQWFKSFDSVEASVKDSVDVIKHHPLF PENVPVHGLVIDPKTGKLDLIVNGYNN*" /label="ytiB CDS" gene complement(2789436..2789999) /gene="ytiB" /locus_tag="BSU_30690" /old_locus_tag="BSU30690" /label="ytiB gene" misc_feature complement(2790024..2790043) /Source="Nicolas_upshift_promotors" /id="U2379" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.718281718281718" /psig="0.999000999001" /xcortree=2374 /SigmaFactorBS="gaaataaggcaggcctgagggtttgtctttttttattatgac gaataaacaagggtTGTGATATATTGAAGAGTAAaaagaatagaaagggacaacgaac a" /listShort="ytiB, S1173, luxS, ytkA, S1172, dps" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2790039) /Source="Nicolas_upshifts" /id="U2379" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.718281718281718" /psig="0.999000999001" /xcortree=2374 /SigmaFactorBS="gaaataaggcaggcctgagggtttgtctttttttattatgac gaataaacaagggtTGTGATATATTGAAGAGTAAaaagaatagaaagggacaacgaac a" /listShort="ytiB, S1173, luxS, ytkA, S1172, dps" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2790093..2790341) /gene="rpmEB" /locus_tag="BSU_30700" /old_locus_tag="BSU30700" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15049826, 16014871, 16547061, 19648245, 20208344" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15049826, 16014871, 16547061, 19648245, 20208344; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosomal protein L31" /protein_id="NP_390948.1" /db_xref="EnsemblGenomes-Gn:BSU30700" /db_xref="EnsemblGenomes-Tr:CAB15048" /db_xref="GOA:O34967" /db_xref="InterPro:IPR002150" /db_xref="InterPro:IPR027493" /db_xref="InterPro:IPR034704" /db_xref="SubtiList:BG13862" /db_xref="UniProtKB/Swiss-Prot:O34967" /translation="MKEGIHPKNHKVIFQDVNSGYRFLSTSTKTSNETAEWEDGNTYP VIKVEVSSDTHPFYTGRQKFNEKGGRVEQFKKRYNMGK*" /label="rpmEB CDS" gene complement(2790093..2790341) /gene="rpmEB" /locus_tag="BSU_30700" /old_locus_tag="BSU30700" /label="rpmEB gene" downshifts complement(2790114) /Source="Nicolas_upshifts" /id="D1583" /incds=0 /nref=96 /ntot=217 /MaxReadThrough="7.96356" /MaxDrop="4.50701" /score="15.8096104" /energy="-7.5" /TU="U2380" /idTUdmin="U2380" /TUdmin="-2288" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2790369..2790388) /Source="Nicolas_upshift_promotors" /id="U2380" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.571428571428571" /psig="0.994005994005994" /xcortree=663 /SigmaFactorBS="cctattcttaaatgccatgaggtttacgatgtgaaacagagg gaaggatataagaagATTGACAAaacgtttgtaaggTTATAAAATAAAACGTAATTat t" /listShort="rpmEB, ytiB, S1173, luxS, ytkA, S1172" /listLong="dps, S1171, ytkC, S1170, ytkD" /label="promotor_-10" promotor_-35 complement(2790402..2790409) /Source="Nicolas_upshift_promotors" /id="U2380" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.571428571428571" /psig="0.994005994005994" /xcortree=663 /SigmaFactorBS="cctattcttaaatgccatgaggtttacgatgtgaaacagagg gaaggatataagaagATTGACAAaacgtttgtaaggTTATAAAATAAAACGTAATTat t" /listShort="rpmEB, ytiB, S1173, luxS, ytkA, S1172" /listLong="dps, S1171, ytkC, S1170, ytkD" /label="promotor_-35" upshifts complement(2790406) /Source="Nicolas_upshifts" /id="U2380" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.571428571428571" /psig="0.994005994005994" /xcortree=663 /SigmaFactorBS="cctattcttaaatgccatgaggtttacgatgtgaaacagagg gaaggatataagaagATTGACAAaacgtttgtaaggTTATAAAATAAAACGTAATTat t" /listShort="rpmEB, ytiB, S1173, luxS, ytkA, S1172" /listLong="dps, S1171, ytkC, S1170, ytkD" /label="upshifts" promotor_-35 2790468..2790474 /Source="Nicolas_upshift_promotors" /id="U2381" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=902 /SigmaFactorBS="gtaaacctcatggcatttaagaataggaAGAATAAtctaacc gaggaaGCAAATAATAAAcccaaaatacatacagaacgtctttttggaaaggtggttt a" /listShort="ythA, ythB" /listLong="ytzL" /label="promotor_-35" promotor_-10 2790488..2790499 /Source="Nicolas_upshift_promotors" /id="U2381" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=902 /SigmaFactorBS="gtaaacctcatggcatttaagaataggaAGAATAAtctaacc gaggaaGCAAATAATAAAcccaaaatacatacagaacgtctttttggaaaggtggttt a" /listShort="ythA, ythB" /listLong="ytzL" /label="promotor_-10" upshifts 2790500 /Source="Nicolas_upshifts" /id="U2381" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=902 /SigmaFactorBS="gtaaacctcatggcatttaagaataggaAGAATAAtctaacc gaggaaGCAAATAATAAAcccaaaatacatacagaacgtctttttggaaaggtggttt a" /listShort="ythA, ythB" /listLong="ytzL" /label="upshifts" CDS 2790546..2791877 /gene="ythA" /locus_tag="BSU_30710" /old_locus_tag="BSU30710" /EC_number="1.10.3.-" /function="16.10: Respire" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9852001, 10551842, 15849754, 16850406, 17114254; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative cytochrome bd menaquinol oxidase subunit I" /protein_id="NP_390949.2" /db_xref="EnsemblGenomes-Gn:BSU30710" /db_xref="EnsemblGenomes-Tr:CAB15049" /db_xref="GOA:C0SP90" /db_xref="InterPro:IPR002585" /db_xref="SubtiList:BG13857" /db_xref="UniProtKB/Swiss-Prot:C0SP90" /translation="MDDLVLARSLFGTTMGFHIIFATLGVGLPLMILVAELIYQKTKD DHYAIMAKRWTKAQAVLLGVAIPTGTIAGTQLALLWPGFMEVIGRVMSLPFQIEIYAF FVEALFMSIYVYAADRLSPAMRIVAVFFVLVGAAASAVLITNVHAFEGTPAGFKILNG KITDVDPWAAFFNPSFFITAGHVVLSAFMTGAFIVASVAAYKMIRTRKKERVYRFHRK ALLLALTIGGIFSLLTALNGHESAQMLYEYQPEKLAGAEGLFETRSHAPLAIGGFTDP NEEKVKWAIEIPWALSFLAANRFDTVVKGLNAFPRDEWPPLFIHTLFNAMVGVGMLLI LYSIIGVVWRKVLKKDRFPTWLLIIFMTAGPFSLIGIEFGWIFACTGRQPWVIYHLLK TSDVVTTTGSIGVLFLFFTFVYAVLGAAVVYVLLYYFRKHPVDEDLNTAES*" /label="ythA CDS" gene 2790546..2791877 /gene="ythA" /locus_tag="BSU_30710" /old_locus_tag="BSU30710" /label="ythA gene" CDS 2791921..2792961 /gene="ythB" /locus_tag="BSU_30720" /old_locus_tag="BSU30720" /EC_number="1.10.3.-" /function="16.10: Respire" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11073895, 15576792, 15849754, 16850406, 10551842; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative cytochrome bd menaquinol oxidase subunit II" /protein_id="NP_390950.1" /db_xref="EnsemblGenomes-Gn:BSU30720" /db_xref="EnsemblGenomes-Tr:CAB15050" /db_xref="GOA:O34505" /db_xref="InterPro:IPR003317" /db_xref="SubtiList:BG13858" /db_xref="UniProtKB/Swiss-Prot:O34505" /translation="MEISTDALIAISIIWGFVFIYAVMATMDFGAGFWSMIYLNKEHM KATDIANRFLSPTWEVTNVFIVAIVVALFSFFPGATFVLGTVLLIPGSMILLLLAIRS GFLVFSNTAKERKTLRYISGISGFIIPAILILVLPVTHGGFIEKTDGIYNLNMSKIFS SPNAYSFIGFAILSTLFLSSLLLADFSNVAEEQDAYRAYRKSALITGPISLLFAVCIM VTMRNEANWLYSGMMNDFSWIIASFITFVIAGIALFLPNKSFGQNIGKPRLALVAIGI QYFLASYAYGRAHLPYMIYPDVTVMSGFTEPATFRALFATYIVAFIILFPGFFFFWKM FMRDKRYIRQEE*" /label="ythB CDS" gene 2791921..2792961 /gene="ythB" /locus_tag="BSU_30720" /old_locus_tag="BSU30720" /label="ythB gene" promotor_-35 2792955..2792961 /Source="Nicolas_upshift_promotors" /id="U2382" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=831 /SigmaFactorBS="atgcgagataaacgctatatccgccaggaGGAATAGagggca agccagccGGCTATACTAATccagaacctttataaggaggggatggcatggagcagaa a" /listShort="ytzL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2792976..2792987 /Source="Nicolas_upshift_promotors" /id="U2382" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=831 /SigmaFactorBS="atgcgagataaacgctatatccgccaggaGGAATAGagggca agccagccGGCTATACTAATccagaacctttataaggaggggatggcatggagcagaa a" /listShort="ytzL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2792986 /Source="Nicolas_upshifts" /id="U2382" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=831 /SigmaFactorBS="atgcgagataaacgctatatccgccaggaGGAATAGagggca agccagccGGCTATACTAATccagaacctttataaggaggggatggcatggagcagaa a" /listShort="ytzL" /GFF_Attribute="listLong" /label="upshifts" CDS 2793015..2793173 /gene="ytzL" /locus_tag="BSU_30739" /old_locus_tag="BSU30739" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 17322312" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097775.1" /db_xref="EnsemblGenomes-Gn:BSU30739" /db_xref="EnsemblGenomes-Tr:CAX52681" /db_xref="InterPro:IPR011437" /db_xref="UniProtKB/Swiss-Prot:C0H3Q2" /translation="MEQKILCEVNNCSYWGKGNKCTADAIYVVSHTGETAENSRETDC KTFKPHDL*" /label="ytzL CDS" gene 2793015..2793173 /gene="ytzL" /locus_tag="BSU_30739" /old_locus_tag="BSU30739" /label="ytzL gene" downshifts 2793162 /Source="Nicolas_upshifts" /id="D1584" /incds=0 /nref=55 /ntot=88 /MaxReadThrough="1.7679" /MaxDrop="7.01398" /score="-5.86934022" /energy="-7" /TU="NA" /idTUdmin="U2382" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2793192..2794079) /gene="mntD" /locus_tag="BSU_30740" /old_locus_tag="BSU30740" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:49350, 15849754, 15948947, 16566604, 16704341, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 49350, 15849754, 15948947, 16566604, 16704341, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="manganese ABC transporter (permease)" /protein_id="NP_390952.1" /db_xref="EnsemblGenomes-Gn:BSU30740" /db_xref="EnsemblGenomes-Tr:CAB15052" /db_xref="GOA:O34500" /db_xref="InterPro:IPR001626" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG13854" /db_xref="UniProtKB/Swiss-Prot:O34500" /translation="MSFEAWIIATGVLVGVSCGLIGTFLVLRSMAMLADAISHTVLLG IVGAFLVTGSLDGIYMFIGAAATGLLTAFLVQLLHSKGVQSDAAIGVVFTSLFAIGVI LLSVYGANVHLDIEHSLMGEIAFVPWNTVTVFGVDIGPKAFWMLASVLVLNVVLISVC YKEFKIASFDPQMALALGIPVLLIHYVQMGMLSLTTVASFDSVGAVLVVAMLIVPPAA AHLLTDRLLYMLILSALIGGLSAVMGYFFATWLNVSISGAMAAMTGVCYASAFLFSPA NGVITKKLRTLNMQKERAG*" /label="mntD CDS" gene complement(2793192..2794079) /gene="mntD" /locus_tag="BSU_30740" /old_locus_tag="BSU30740" /label="mntD gene" downshifts complement(2793215) /Source="Nicolas_upshifts" /id="D1585" /incds=0 /nref=121 /ntot=218 /MaxReadThrough="3.39755" /MaxDrop="6.80546" /score="-8.37820006" /energy="-7" /TU="U2385" /idTUdmin="U2385" /TUdmin="-637" /isTUend="FALSE" /label="downshifts" CDS complement(2794069..2795376) /gene="mntC" /locus_tag="BSU_30750" /old_locus_tag="BSU30750" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:49350, 15849754, 15948947, 16566604, 16704341, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 49350, 15849754, 15948947, 16566604, 16704341, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="manganese ABC transporter (permease)" /protein_id="NP_390953.1" /db_xref="EnsemblGenomes-Gn:BSU30750" /db_xref="EnsemblGenomes-Tr:CAB15053" /db_xref="GOA:O35024" /db_xref="InterPro:IPR001626" /db_xref="InterPro:IPR035568" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG13853" /db_xref="UniProtKB/Swiss-Prot:O35024" /translation="MFESLWLQLQHPNTQWVLAGTLLLGTASGVLGSFVLLRKQSLIG DAMAHSALPGVCLAFLFTGQKSLPFFLLGAALAGLLGTFCIQLIPRLSKTKEDSAIGI VLSVFFGVGIILLTYIQQQGAGSQSGLDSFLFGQAASLVRQDIILIAGISAVLLLLCI VFFKEFTLITFDLAFAKGLGIPVRFLNGLLACLIVCAVVIGLQTVGVILMAAMLITPA ITARYWTERLTGMIIIAGITGGVSGVAGTLLSTTMKGMATGPLMILSATLLFLFSMIC APKRGLAAKAIRLMRLRRRTSREQVLLAIYEQYEKNNLCVTVESVRKKRRLSPSLCLK ALNDLEQERCIERIENGIWQITSKGIEKGYHTALKQRMYEVYLMHEMELANIESDQDY FDPDRLPRETRERLYSLLKLYGRMPERRKASHDAEKGQIANEF*" /label="mntC CDS" gene complement(2794069..2795376) /gene="mntC" /locus_tag="BSU_30750" /old_locus_tag="BSU30750" /label="mntC gene" CDS complement(2795382..2796134) /gene="mntB" /locus_tag="BSU_30760" /old_locus_tag="BSU30760" /EC_number="3.6.3.-" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10760146, 15948947, 16566604, 16704341" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10760146, 15948947, 16566604, 16704341; Product type t: transporter" /codon_start=1 /transl_table=11 /product="manganese ABC transporter (ATP-binding protein)" /protein_id="NP_390954.1" /db_xref="EnsemblGenomes-Gn:BSU30760" /db_xref="EnsemblGenomes-Tr:CAB15054" /db_xref="GOA:O34338" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13852" /db_xref="UniProtKB/Swiss-Prot:O34338" /translation="MFPVELDNVTVAYHKKPVLQDISLQVPEGKLIGIIGPNGAGKST LIKTILGLVPRASGDISIYGKDYKDQRTRIGYVPQRGSVDWDFPTSPLDVVLMGRYGR IGLLKRPKKADVEMAKAALTKVGMHDYAKRQISQLSGGQQQRVFLARALCQNADIYFM DEPFAGVDAATERAIMTLLAELKEKGKTVLVVHHDLQTAEDYFDWILLLHLRKIAFGP TENVFTIENLQKTYGGRLTFLKDKVLAEGHKE*" /label="mntB CDS" gene complement(2795382..2796134) /gene="mntB" /locus_tag="BSU_30760" /old_locus_tag="BSU30760" /label="mntB gene" CDS complement(2796153..2797073) /gene="mntA" /locus_tag="BSU_30770" /old_locus_tag="BSU30770" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10760146, 15948947, 16566604, 16704341" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10760146, 15948947, 16566604, 16704341; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="manganese ABC transporter (manganese binding lipoprotein)" /protein_id="NP_390955.1" /db_xref="EnsemblGenomes-Gn:BSU30770" /db_xref="EnsemblGenomes-Tr:CAB15055" /db_xref="GOA:O34385" /db_xref="InterPro:IPR006127" /db_xref="InterPro:IPR006128" /db_xref="InterPro:IPR006129" /db_xref="SubtiList:BG13851" /db_xref="UniProtKB/Swiss-Prot:O34385" /translation="MRQGLMAAVLFATFALTGCGTDSAGKSADQQLQVTATTSQIADA AENIGGKHVKVTSLMGPGVDPHLYKASQGDTKKLMSADVVLYSGLHLEGKMEDVLQKI GEQKQSAAVAEAIPKNKLIPAGEGKTFDPHVWFSIPLWIYAVDEIEAQFSKAMPQHAD AFRKNAKEYKEDLQYLDKWSRKEIAHIPEKSRVLVTAHDAFAYFGNEYGFKVKGLQGL STDSDYGLRDVQELVDLLTEKQIKAVFVESSVSEKSINAVVEGAKEKGHTVTIGGQLY SDAMGEKGTKEGTYEGMFRHNINTITKALK*" /label="mntA CDS" gene complement(2796153..2797073) /gene="mntA" /locus_tag="BSU_30770" /old_locus_tag="BSU30770" /label="mntA gene" promotor_-10 complement(2797109..2797120) /Source="Nicolas_upshift_promotors" /id="U2383" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.52047952047952" /psig="0.52047952047952" /xcortree=407 /SigmaFactorBS="aataaaacatgcttttggctaatttaatgtCACATGTctaag aactgacaACATAAGATAAAacaatcggacattgatggcaaagaggaggagaaatatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2797110) /Source="Nicolas_upshifts" /id="U2383" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.52047952047952" /psig="0.52047952047952" /xcortree=407 /SigmaFactorBS="aataaaacatgcttttggctaatttaatgtCACATGTctaag aactgacaACATAAGATAAAacaatcggacattgatggcaaagaggaggagaaatatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2797112..2797203) /Source="Nicolas_S_feature" /locus_tag="new_3145997_3146088_c" /HighExp="T-0.40H, Sw, T-1.40H, BC, C90, C30, BI, T0.0H, T-3.40H, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.985, 0.982" /TUlongSig="NA" /TUlongPSig="NA" /label="S1174" promotor_-35 complement(2797134..2797140) /Source="Nicolas_upshift_promotors" /id="U2383" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.52047952047952" /psig="0.52047952047952" /xcortree=407 /SigmaFactorBS="aataaaacatgcttttggctaatttaatgtCACATGTctaag aactgacaACATAAGATAAAacaatcggacattgatggcaaagaggaggagaaatatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2797188 /Source="Nicolas_upshifts" /id="U2384" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.649350649350649" /psig="0.0549450549450549" /xcortree=296 /SigmaFactorBS="tcttagacatgtgacattaaattagccaaaagcatgttttat ttacacaggacaaaaagtttcCCTCATGCAAAATtatcgcgtttggccatttttgtca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2797189..2797208) /Source="Nicolas_upshift_promotors" /id="U2385" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.596403596403596" /psig="0.985014985014985" /xcortree=1526 /SigmaFactorBS="ctgctgacccagccggtttttttatgtaaatcaGCTTGACAa aaatggccaaacgCGATAATTTTGCATGAGGGAaactttttgtcctgtgtaaataaaa c" /listShort="S1174, mntA, mntB, mntC, mntD" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature 2797191..2797203 /Source="Nicolas_upshift_promotors" /id="U2384" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.649350649350649" /psig="0.0549450549450549" /xcortree=296 /SigmaFactorBS="tcttagacatgtgacattaaattagccaaaagcatgttttat ttacacaggacaaaaagtttcCCTCATGCAAAATtatcgcgtttggccatttttgtca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2797203) /Source="Nicolas_upshifts" /id="U2385" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.596403596403596" /psig="0.985014985014985" /xcortree=1526 /SigmaFactorBS="ctgctgacccagccggtttttttatgtaaatcaGCTTGACAa aaatggccaaacgCGATAATTTTGCATGAGGGAaactttttgtcctgtgtaaataaaa c" /listShort="S1174, mntA, mntB, mntC, mntD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2797205..2797286) /Source="Nicolas_S_feature" /locus_tag="new_3146090_3146171_c" /HighExp="T1.30H, T1.0H, C30, T0.30H, T2.0H, T2.30H, T-0.40H, T-1.40H, T-2.40H, GM 150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.982" /TUlongSig="NA" /TUlongPSig="NA" /label="S1175" promotor_-35 complement(2797223..2797230) /Source="Nicolas_upshift_promotors" /id="U2385" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.596403596403596" /psig="0.985014985014985" /xcortree=1526 /SigmaFactorBS="ctgctgacccagccggtttttttatgtaaatcaGCTTGACAa aaatggccaaacgCGATAATTTTGCATGAGGGAaactttttgtcctgtgtaaataaaa c" /listShort="S1174, mntA, mntB, mntC, mntD" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2797286) /Source="Nicolas_upshifts" /id="U2386" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.837162837162837" /psig="0.982017982017982" /xcortree=2960 /SigmaFactorBS="agcattttgctATTTTGAAtaaatgacactgtGCTGTTACAG TAAAAGTGTTcgttgaatacatcccttctcgtttggaccggctgctgacccagccggt t" /listShort="S1175, S1174, mntA, mntB, mntC" /listLong="mntD" /label="upshifts" promotor_-10 complement(2797295..2797314) /Source="Nicolas_upshift_promotors" /id="U2386" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.837162837162837" /psig="0.982017982017982" /xcortree=2960 /SigmaFactorBS="agcattttgctATTTTGAAtaaatgacactgtGCTGTTACAG TAAAAGTGTTcgttgaatacatcccttctcgtttggaccggctgctgacccagccggt t" /listShort="S1175, S1174, mntA, mntB, mntC" /listLong="mntD" /label="promotor_-10" promotor_-35 complement(2797328..2797335) /Source="Nicolas_upshift_promotors" /id="U2386" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.837162837162837" /psig="0.982017982017982" /xcortree=2960 /SigmaFactorBS="agcattttgctATTTTGAAtaaatgacactgtGCTGTTACAG TAAAAGTGTTcgttgaatacatcccttctcgtttggaccggctgctgacccagccggt t" /listShort="S1175, S1174, mntA, mntB, mntC" /listLong="mntD" /label="promotor_-35" CDS complement(2797353..2798468) /gene="menC" /locus_tag="BSU_30780" /old_locus_tag="BSU30780" /EC_number="4.2.1.113" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:6780514, 8566759, 9139683, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6780514, 8566759, 9139683, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="O-succinylbenzoate-CoA synthase" /protein_id="NP_390956.1" /db_xref="EnsemblGenomes-Gn:BSU30780" /db_xref="EnsemblGenomes-Tr:CAB15056" /db_xref="GOA:O34514" /db_xref="InterPro:IPR010197" /db_xref="InterPro:IPR013341" /db_xref="InterPro:IPR013342" /db_xref="InterPro:IPR029017" /db_xref="InterPro:IPR029065" /db_xref="InterPro:IPR034390" /db_xref="InterPro:IPR036849" /db_xref="SubtiList:BG13847" /db_xref="UniProtKB/Swiss-Prot:O34514" /translation="MIEIEKITLYHLSMNLKKPFKNSIETLQERKFLIVEAIDTSGVT GWGEVSAFSSPWYTEETIGTCLHMLKDFFIPNVVGREFNHPSEVPDSLARYKGNRMAK AGLESAVWDIYAKKKGVSLAEALGGTRDKVPAGVVVGLAPLDDMLKEIESYQKEGYQR IKIKIQPGQDVELVKAIRSRFPTIPLMADANSSYELKDISRLKELDDYHLMMIEQPLQ ADDIVDHRHLQKHLKTAICLDESICSVDDARRAIELGSCKIINIKPSRVGGLTEALKI HDLCKEHHMQVWCGGMLETGISRAQNVALASLPQFTIPGDISSSSRYWDEDIVTPDIR IDNGFISVSKQPGLGVEVNQDIMRKYVTKMDVFTQHG*" /label="menC CDS" gene complement(2797353..2798468) /gene="menC" /locus_tag="BSU_30780" /old_locus_tag="BSU30780" /label="menC gene" downshifts complement(2797396) /Source="Nicolas_upshifts" /id="D1586" /incds=0 /nref=12 /ntot=179 /MaxReadThrough="3.8638" /MaxDrop="2.96378" /score="29.7201414" /energy="-11.1" /TU="U2387,U2388" /idTUdmin="U2388" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(2798465..2799925) /gene="menE" /locus_tag="BSU_30790" /old_locus_tag="BSU30790" /EC_number="6.2.1.26" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6780514, 6780515, 8566759, 9139683, 12682299, 28559280" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6780514, 6780515, 8566759, 9139683, 12682299, 28559280; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="O-succinylbenzoic acid-CoA ligase" /protein_id="NP_390957.1" /db_xref="EnsemblGenomes-Gn:BSU30790" /db_xref="EnsemblGenomes-Tr:CAB15057" /db_xref="GOA:P23971" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR010192" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="PDB:5BUQ" /db_xref="PDB:5BUR" /db_xref="PDB:5BUS" /db_xref="PDB:5GTD" /db_xref="PDB:5X8F" /db_xref="PDB:5X8G" /db_xref="SubtiList:BG10687" /db_xref="UniProtKB/Swiss-Prot:P23971" /translation="MLTEQPNWLMQRAQLTPERIALIYEDQTVTFAELFAASKRMAEQ LAAHSVRKGDTAAILLQNRAEMVYAVHACFLLGVKAVLLNTKLSTHERLFQLEDSGSG FLLTDSSFEKKEYEHIVQTIDVDELMKEAAEEIEIEAYMQMDATATLMYTSGTTGKPK GVQQTFGNHYFSAVSSALNLGITEQDRWLIALPLFHISGLSALFKSVIYGMTVVLHQR FSVSDVLHSINRHEVTMISAVQTMLASLLEETNRCPESIRCILLGGGPAPLPLLEECR EKGFPVFQSYGMTETCSQIVTLSPEFSMEKLGSAGKPLFSCEIKIERDGQVCEPYEHG EIMVKGPNVMKSYFNRESANEASFQNGWLKTGDLGYLDNEGFLYVLDRRSDLIISGGE NIYPAEVESVLLSHPAVAEAGVSGAEDKKWGKVPHAYLVLHKPVSAGELTDYCKERLA KYKIPAKFFVLDRLPRNASNKLLRNQLKDARKGELL*" /label="menE CDS" gene complement(2798465..2799925) /gene="menE" /locus_tag="BSU_30790" /old_locus_tag="BSU30790" /label="menE gene" promotor_-10 complement(2799368..2799386) /Source="Nicolas_upshift_promotors" /id="U2387" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=257 /SigmaFactorBS="cgttcggaaaccattatttcagtgcGGTGTCGtccgctctta atttGGGTATAACAGAACAAGACcgctggcttatcgcattgccgctctttcatatcag c" /listShort="menC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2799372) /Source="Nicolas_upshifts" /id="U2387" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=257 /SigmaFactorBS="cgttcggaaaccattatttcagtgcGGTGTCGtccgctctta atttGGGTATAACAGAACAAGACcgctggcttatcgcattgccgctctttcatatcag c" /listShort="menC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2799401..2799407) /Source="Nicolas_upshift_promotors" /id="U2387" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=257 /SigmaFactorBS="cgttcggaaaccattatttcagtgcGGTGTCGtccgctctta atttGGGTATAACAGAACAAGACcgctggcttatcgcattgccgctctttcatatcag c" /listShort="menC" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2800014) /Source="Nicolas_upshifts" /id="D1587" /incds=0 /nref=1 /ntot=97 /MaxReadThrough="4.92536" /MaxDrop="2.4145" /score="1.01127104" /energy="-10.8" /TU="U2388" /idTUdmin="U2389" /TUdmin=682 /isTUend="FALSE" /label="downshifts" CDS complement(2800016..2800831) /gene="menB" /locus_tag="BSU_30800" /old_locus_tag="BSU30800" /EC_number="4.1.3.36" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:6780514, 6780515, 8566759, 9139683, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6780514, 6780515, 8566759, 9139683, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydroxynapthoic acid synthetase" /protein_id="NP_390958.1" /db_xref="EnsemblGenomes-Gn:BSU30800" /db_xref="EnsemblGenomes-Tr:CAB15058" /db_xref="GOA:P23966" /db_xref="InterPro:IPR001753" /db_xref="InterPro:IPR010198" /db_xref="InterPro:IPR014748" /db_xref="InterPro:IPR018376" /db_xref="InterPro:IPR029045" /db_xref="SubtiList:BG10686" /db_xref="UniProtKB/Swiss-Prot:P23966" /translation="MAEWKTKRTYDEILYETYNGIAKITINRPEVHNAFTPKTVAEMI DAFADARDDQNVGVIVLAGAGDKAFCSGGDQKVRGHGGYVGDDQIPRLNVLDLQRLIR VIPKPVVAMVSGYAIGGGHVLHIVCDLTIAADNAIFGQTGPKVGSFDAGYGSGYLARI VGHKKAREIWYLCRQYNAQEALDMGLVNTVVPLEQLEEETIKWCEEMLEKSPTALRFL KAAFNADTDGLAGIQQFAGDATLLYYTTDEAKEGRDSFKEKRKPDFGQFPRFP*" /label="menB CDS" gene complement(2800016..2800831) /gene="menB" /locus_tag="BSU_30800" /old_locus_tag="BSU30800" /label="menB gene" CDS complement(2800866..2801690) /gene="menH" /locus_tag="BSU_30810" /old_locus_tag="BSU30810" /EC_number="4.2.99.20" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12454479, 23637813; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase" /protein_id="NP_390959.1" /db_xref="EnsemblGenomes-Gn:BSU30810" /db_xref="EnsemblGenomes-Tr:CAB15059" /db_xref="GOA:P23974" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR000639" /db_xref="InterPro:IPR022485" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG10685" /db_xref="UniProtKB/Swiss-Prot:P23974" /translation="MGTVNITVSDGVRYAVADEGPNASEAVVCLHGFTGSKQSWTFLD EMLPDSRLIKIDCLGHGETDAPLNGKRYSTTRQVSDLAEIFDQLKLHKVKLIGYSMGG RLAYSFAMTYPERVSALVLESTTPGLKTLGERRERIMRDRKLADFILRDGLEAFVAYW ENIPLFSSQQRLAEDIRYRIRSGRLRNNKIGLANSLTGMGTGSQPSLWSRVEEIDVPV LLICGEWDEKFCAINQEVHKMLPSSRIEIVPKAGHTVHVEQPRLFGKIVSEFLTSI*" /label="menH CDS" gene complement(2800866..2801690) /gene="menH" /locus_tag="BSU_30810" /old_locus_tag="BSU30810" /label="menH gene" promotor_-10 complement(2800948..2800967) /Source="Nicolas_upshift_promotors" /id="U2388" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.534465534465534" /psig="0.993006993006993" /xcortree=2696 /SigmaFactorBS="aattttgcgccatcaatcaagaGGTGcataagatgcttcctT CTAGTAGAATAGAGATTGTtccaaaagcaggacatacggtccatgtggagcagccgcg a" /listShort="menB, menE, menC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2800948) /Source="Nicolas_upshifts" /id="U2388" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.534465534465534" /psig="0.993006993006993" /xcortree=2696 /SigmaFactorBS="aattttgcgccatcaatcaagaGGTGcataagatgcttcctT CTAGTAGAATAGAGATTGTtccaaaagcaggacatacggtccatgtggagcagccgcg a" /listShort="menB, menE, menC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2800983..2800986) /Source="Nicolas_upshift_promotors" /id="U2388" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.534465534465534" /psig="0.993006993006993" /xcortree=2696 /SigmaFactorBS="aattttgcgccatcaatcaagaGGTGcataagatgcttcctT CTAGTAGAATAGAGATTGTtccaaaagcaggacatacggtccatgtggagcagccgcg a" /listShort="menB, menE, menC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2801114) /Source="Nicolas_upshifts" /id="U2389" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.706293706293706" /psig="0.706293706293706" /xcortree=1445 /SigmaFactorBS="gctgaagatattcggtacAGGATACgatcgggccgtctgCGG AACAATAAGattgggcttgcgaacagtttaaccggcatgggcaccggttcacagcctt c" /listShort="menB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2801124..2801135) /Source="Nicolas_upshift_promotors" /id="U2389" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.706293706293706" /psig="0.706293706293706" /xcortree=1445 /SigmaFactorBS="gctgaagatattcggtacAGGATACgatcgggccgtctgCGG AACAATAAGattgggcttgcgaacagtttaaccggcatgggcaccggttcacagcctt c" /listShort="menB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2801150..2801156) /Source="Nicolas_upshift_promotors" /id="U2389" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.706293706293706" /psig="0.706293706293706" /xcortree=1445 /SigmaFactorBS="gctgaagatattcggtacAGGATACgatcgggccgtctgCGG AACAATAAGattgggcttgcgaacagtttaaccggcatgggcaccggttcacagcctt c" /listShort="menB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2801678..2803420) /gene="menD" /locus_tag="BSU_30820" /old_locus_tag="BSU30820" /EC_number="2.2.1.9" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:6780514, 8169214, 8566759, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6780514, 8169214, 8566759, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-oxoglutarate decarboxylase and 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylic-acid synthase" /protein_id="NP_390960.1" /db_xref="EnsemblGenomes-Gn:BSU30820" /db_xref="EnsemblGenomes-Tr:CAB15060" /db_xref="GOA:P23970" /db_xref="InterPro:IPR004433" /db_xref="InterPro:IPR011766" /db_xref="InterPro:IPR012001" /db_xref="InterPro:IPR029035" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR032264" /db_xref="PDB:2X7J" /db_xref="SubtiList:BG10683" /db_xref="UniProtKB/Swiss-Prot:P23970" /translation="MTVNPITHYIGSFIDEFALSGITDAVVCPGSRSTPLAVLCAAHP DISVHVQIDERSAGFFALGLAKAKQRPVLLICTSGTAAANFYPAVVEAHYSRVPIIVL TADRPHELREVGAPQAINQHFLFGNFVKFFTDSALPEESPQMLRYIRTLASRAAGEAQ KRPMGPVHVNVPLREPLMPDLSDEPFGRMRTGRHVSVKTGTQSVDRESLSDVAEMLAE AEKGMIVCGELHSDADKENIIALSKALQYPILADPLSNLRNGVHDKSTVIDAYDSFLK DDELKRKLRPDVVIRFGPMPVSKPVFLWLKDDPTIQQIVIDEDGGWRDPTQASAHMIH CNASVFAEEIMAGLTAATRSSEWLEKWQFVNGRFREHLQTISSEDVSFEGNLYRILQH LVPENSSLFVGNSMPIRDVDTFFEKQDRPFRIYSNRGANGIDGVVSSAMGVCEGTKAP VTLVIGDLSFYHDLNGLLAAKKLGIPLTVILVNNDGGGIFSFLPQASEKTHFEDLFGT PTGLDFKHAAALYGGTYSCPASWDEFKTAYAPQADKPGLHLIEIKTDRQSRVQLHRDM LNEAVREVKKQWEL*" /label="menD CDS" gene complement(2801678..2803420) /gene="menD" /locus_tag="BSU_30820" /old_locus_tag="BSU30820" /label="menD gene" CDS complement(2803417..2804832) /gene="menF" /locus_tag="BSU_30830" /old_locus_tag="BSU30830" /EC_number="5.4.4.2" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6780514, 8169214, 8566759" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6780514, 8169214, 8566759; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="menaquinone-specific isochorismate synthase" /protein_id="NP_390961.1" /db_xref="EnsemblGenomes-Gn:BSU30830" /db_xref="EnsemblGenomes-Tr:CAB15061" /db_xref="GOA:P23973" /db_xref="InterPro:IPR004561" /db_xref="InterPro:IPR005801" /db_xref="InterPro:IPR015890" /db_xref="InterPro:IPR034681" /db_xref="SubtiList:BG10682" /db_xref="UniProtKB/Swiss-Prot:P23973" /translation="MVTTVQRTFRKEVLHALHKAKEVNHAVLISYSRQIESLDPLSFF NYGAKKYTGNRFFWSDPESELTIVGLGKEAVFQTNQKNSERYREVFEQWERFKKTAFH IYEEEKLQHSAVGPVLFGGFSFDPCEERGSQWDHFSEGDFFVPALMLTMTAEGPFLTV NRWVSGGEDAEAVLEGLKAFAAEFMVPDFKQEDQAVIAAAEELDKDDWLKAIETATSQ IKEKQYDKVVLARELLLTFDGPIQIEPVLKTLLDDQQTSYVFAIEQEGKTFVGASPER LIKRDGGTVMSSCLAGSIKRGVNEEDDRRIGLELLNDEKNLLEHDIVVGMIHNAFVSS CSEVEKPDGPVLYKTKSVQHLFTPIVGQLRESASIFDLIEKLHPTPALGGSPQEKAVD VIREIEPMSRGWYAAPIGWIDSQDNGEFAVAIRSGLIEGSTARLFAGCGIVEDSEPIS EYEETQIKLKPMISALGGERR*" /label="menF CDS" gene complement(2803417..2804832) /gene="menF" /locus_tag="BSU_30830" /old_locus_tag="BSU30830" /label="menF gene" S_feature complement(2804833..2804945) /Source="Nicolas_S_feature" /locus_tag="new_3153718_3153830_c" /HighExp="dia5, LBGstat, Diami, LBGtran, dia15, H2O2, G180, G150, LPhT, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1176" promotor_-10 complement(2804925..2804944) /Source="Nicolas_upshift_promotors" /id="U2390" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.721278721278721" /psig=1 /xcortree=1834 /SigmaFactorBS="caacctttgctatcagtggagaaagaaatttaagctttgttt CTTTttcatttctgaaattAGGTTTATAATAGGTAAGGCaggccatttggactgcatg a" /listShort="S1176, menF, menD, ytxM" /listLong="menB, menE, menC" /label="promotor_-10" upshifts complement(2804945) /Source="Nicolas_upshifts" /id="U2390" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.721278721278721" /psig=1 /xcortree=1834 /SigmaFactorBS="caacctttgctatcagtggagaaagaaatttaagctttgttt CTTTttcatttctgaaattAGGTTTATAATAGGTAAGGCaggccatttggactgcatg a" /listShort="S1176, menF, menD, ytxM" /listLong="menB, menE, menC" /label="upshifts" S_feature complement(2804947..2805097) /Source="Nicolas_S_feature" /locus_tag="new_3153832_3153982_c" /HighExp="S8, S7, S6, S5, BT, S4, Pyr, B36, G/S, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1177" promotor_-35 complement(2804960..2804963) /Source="Nicolas_upshift_promotors" /id="U2390" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.721278721278721" /psig=1 /xcortree=1834 /SigmaFactorBS="caacctttgctatcagtggagaaagaaatttaagctttgttt CTTTttcatttctgaaattAGGTTTATAATAGGTAAGGCaggccatttggactgcatg a" /listShort="S1176, menF, menD, ytxM" /listLong="menB, menE, menC" /label="promotor_-35" promotor_-35 2805058..2805064 /Source="Nicolas_upshift_promotors" /id="U2391" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=863 /SigmaFactorBS="aaaacctcctatattcctccacccgccatttaTGAAAGTtct caggcgatctGTTCATACTAAAggtatgcatcacagagaaacgaggcgatcacattgc t" /listShort="yteA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2805078..2805097) /Source="Nicolas_upshift_promotors" /id="U2392" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1266 /SigmaFactorBS="attttttaaatgctgaagctgttctttcgtaagcaatGTGAT CGCCTcgtttctctgtgaTGCATACCTTTAGTATGAACagatcgcctgagaactttca t" /listShort="S1177, S1176, menF" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 2805078..2805089 /Source="Nicolas_upshift_promotors" /id="U2391" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=863 /SigmaFactorBS="aaaacctcctatattcctccacccgccatttaTGAAAGTtct caggcgatctGTTCATACTAAAggtatgcatcacagagaaacgaggcgatcacattgc t" /listShort="yteA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2805086 /Source="Nicolas_upshifts" /id="U2391" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=863 /SigmaFactorBS="aaaacctcctatattcctccacccgccatttaTGAAAGTtct caggcgatctGTTCATACTAAAggtatgcatcacagagaaacgaggcgatcacattgc t" /listShort="yteA" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2805097) /Source="Nicolas_upshifts" /id="U2392" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1266 /SigmaFactorBS="attttttaaatgctgaagctgttctttcgtaagcaatGTGAT CGCCTcgtttctctgtgaTGCATACCTTTAGTATGAACagatcgcctgagaactttca t" /listShort="S1177, S1176, menF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2805111..2805120) /Source="Nicolas_upshift_promotors" /id="U2392" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1266 /SigmaFactorBS="attttttaaatgctgaagctgttctttcgtaagcaatGTGAT CGCCTcgtttctctgtgaTGCATACCTTTAGTATGAACagatcgcctgagaactttca t" /listShort="S1177, S1176, menF" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2805122..2805841 /gene="yteA" /locus_tag="BSU_30840" /old_locus_tag="BSU30840" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15496987; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative regulatory protein" /protein_id="NP_390962.2" /db_xref="EnsemblGenomes-Gn:BSU30840" /db_xref="EnsemblGenomes-Tr:CAB15062" /db_xref="GOA:P42408" /db_xref="InterPro:IPR000962" /db_xref="InterPro:IPR014240" /db_xref="InterPro:IPR037187" /db_xref="SubtiList:BG11200" /db_xref="UniProtKB/Swiss-Prot:P42408" /translation="MLTKEQLQHLKNELEQTKKDILNRFKDNDHFQLNSAFPYDSWGE LSAYDNHPGDQATELYEREKDIALDLHEREHLRDIEHSLKAIENGTYGICEVSGKEIP FERLEALPTATTLAEYSSQDVVSKDRPIEEETPFGQFEFDDDEEIRAPYDSEDSYQDV EKYGNSQTPQDMENPPLSYDDMTMNAEENIGNTESYENFIATDITGKEITVYQSRAHE RYEEELDEEGIMTTFGDLHAD*" /label="yteA CDS" gene 2805122..2805841 /gene="yteA" /locus_tag="BSU_30840" /old_locus_tag="BSU30840" /label="yteA gene" S_feature complement(2805192..2805849) /Source="Nicolas_S_feature" /locus_tag="new_3154077_3154734_c" /HighExp="S8, S6, S7, BT, B36, S5, S4, G/S, Pyr, S3" /AntisenseName="yteA" /AntisenseCor="0.85796245341056299" /AntisenseRegPval="-78.5" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1178" downshifts 2805830 /Source="Nicolas_upshifts" /id="D1588" /incds=0 /nref=23 /ntot=40 /MaxReadThrough="0.72949" /MaxDrop="5.85132" /score="2.75726503" /energy="-10.1" /TU="NA" /idTUdmin="U2391" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" CDS complement(2805850..2806668) /gene="ytdA" /locus_tag="BSU_30850" /old_locus_tag="BSU30850" /EC_number="2.7.7.9" /function="16.8: Protect" /function="16.14: Store" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative UTP-glucose-1-phosphate uridylyltransferase" /protein_id="NP_390963.1" /db_xref="EnsemblGenomes-Gn:BSU30850" /db_xref="EnsemblGenomes-Tr:CAB15063" /db_xref="GOA:P42407" /db_xref="InterPro:IPR005835" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG11199" /db_xref="UniProtKB/Swiss-Prot:P42407" /translation="MIKKAIIPAGGFGTRNLPVTKVIPKEMFPVGSKPVIHYLVEELK ESGIEDILMVVSSHKNLIVDYFDSSLALEAFLASKNKLHLLREHPIPDIRIHYVRQPY AKGLGDAISFGKQFAGGEPFAVVLPDDLIFSANQPALGQLIEAYTKYQSSVIGLKETK TEDLHHYGVIKGEPVEKGLYRIQDIVEKPKQNPPSHFAAAGRYIFTPDIFNELEALEA DSGGEVQVTDAIKASLGACTVYGKLLEGERYDIGLQKDYLKLIYDMLKTEKNPQ*" /label="ytdA CDS" gene complement(2805850..2806668) /gene="ytdA" /locus_tag="BSU_30850" /old_locus_tag="BSU30850" /label="ytdA gene" promotor_-10 complement(2806689..2806708) /Source="Nicolas_upshift_promotors" /id="U2393" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1317 /SigmaFactorBS="tctgcccagttgcttccgcctaatttcagatgTACAAACATc gggatgcgctcttGGAATATCATGTAATAAACAtgagctgaggggaaaataccatgat a" /listShort="ytdA, S1178" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2806703) /Source="Nicolas_upshifts" /id="U2393" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1317 /SigmaFactorBS="tctgcccagttgcttccgcctaatttcagatgTACAAACATc gggatgcgctcttGGAATATCATGTAATAAACAtgagctgaggggaaaataccatgat a" /listShort="ytdA, S1178" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2806723..2806731) /Source="Nicolas_upshift_promotors" /id="U2393" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1317 /SigmaFactorBS="tctgcccagttgcttccgcctaatttcagatgTACAAACATc gggatgcgctcttGGAATATCATGTAATAAACAtgagctgaggggaaaataccatgat a" /listShort="ytdA, S1178" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2806769..2806777 /Source="Nicolas_upshift_promotors" /id="U2394" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1301 /SigmaFactorBS="acatctgaaattaggcggaagcaactgggcagaaagcgGAAT CACGAaccagcccttttTTAATAGGATATTGATATATgaccagtaatcttgtaaagga g" /listShort="ytcA, ytcB, ytcC, S1179" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2806790..2806809 /Source="Nicolas_upshift_promotors" /id="U2394" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1301 /SigmaFactorBS="acatctgaaattaggcggaagcaactgggcagaaagcgGAAT CACGAaccagcccttttTTAATAGGATATTGATATATgaccagtaatcttgtaaagga g" /listShort="ytcA, ytcB, ytcC, S1179" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2806791 /Source="Nicolas_upshifts" /id="U2394" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1301 /SigmaFactorBS="acatctgaaattaggcggaagcaactgggcagaaagcgGAAT CACGAaccagcccttttTTAATAGGATATTGATATATgaccagtaatcttgtaaagga g" /listShort="ytcA, ytcB, ytcC, S1179" /GFF_Attribute="listLong" /label="upshifts" CDS 2806840..2808126 /gene="ytcA" /locus_tag="BSU_30860" /old_locus_tag="BSU30860" /EC_number="1.1.1.22" /function="16.14: Store" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative UDP-glucose dehydrogenase" /protein_id="NP_390964.1" /db_xref="EnsemblGenomes-Gn:BSU30860" /db_xref="EnsemblGenomes-Tr:CAB15064" /db_xref="GOA:O34862" /db_xref="InterPro:IPR001732" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR014026" /db_xref="InterPro:IPR014027" /db_xref="InterPro:IPR017476" /db_xref="InterPro:IPR028357" /db_xref="InterPro:IPR036220" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13828" /db_xref="UniProtKB/Swiss-Prot:O34862" /translation="MKICVVGAGYVGLTLSAALASIGHDMICTDKDVKKIGQLKKGVI PFYEPGLSDAILRCGNLSFSSEVKSSMEECPVIFIAVGTPPRSDGSADTKALQSVIGD LSEAIRSYKTIITKSTVPPGTNENIAKQLIASGVSKNLFNIVSNPEFLREGNALYDML HPDKTVIGVQEEDHVSAAIVKSIYKHIDTPFIVTSLAGAELIKYANNFFLAAKISFIN EMARICEAYQSDISDISRAIGLDPRIGKHFLQAGIGYGGSCFPKDLQALQFAAQEKNT ETFLLRAVQHINDTQLGLYIKKIQSFFETLQGKKAAVLGISFKPNTDDIRNSQAVRLM ERLAELGCDVHAYDPEAVLPEHLRQHVTQHSQAFDAIEESDFLFLATEWSEFLAFDWK KAADIMKGRLVIDGRNVLKKELIEACGLICTGVGRP*" /label="ytcA CDS" gene 2806840..2808126 /gene="ytcA" /locus_tag="BSU_30860" /old_locus_tag="BSU30860" /label="ytcA gene" CDS 2808123..2809073 /gene="ytcB" /locus_tag="BSU_30870" /old_locus_tag="BSU30870" /EC_number="5.1.3.2" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative UDP-glucose epimerase" /protein_id="NP_390965.1" /db_xref="EnsemblGenomes-Gn:BSU30870" /db_xref="EnsemblGenomes-Tr:CAB15065" /db_xref="GOA:O34886" /db_xref="InterPro:IPR001509" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13829" /db_xref="UniProtKB/Swiss-Prot:O34886" /translation="MKILVTGAAGFIGSHLCEELLKDKKHNVIGIDDFIGPTPFSLKL KNLKNLLPEKRFTFIKENLLTADLASLLEGVDVIFHLAAIPGVRSSWGNHFHPYAAHN IQALQRLLEACREHSIQTFVFASTSSVYGEKQGKVSENTSLSPLSPYGVTKLTGEKLC HVYKQSFGIPIVILRFFTVYGPRQRPDMAFHRLIKQHLQQKPLTIFGDGQQSRDFTYI SDCVKGITAVLGKPHLIGETVNIGGAERASVLKVVSLIEDISGRKATLHFSDKIAGEP SNTWADISKAKQLLHYDPATSLKDGLTNEIAYLSSLYQGE*" /label="ytcB CDS" gene 2808123..2809073 /gene="ytcB" /locus_tag="BSU_30870" /old_locus_tag="BSU30870" /label="ytcB gene" CDS 2809076..2810299 /gene="ytcC" /locus_tag="BSU_30880" /old_locus_tag="BSU30880" /EC_number="2.4.1.-" /function="16.14: Store" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glucosyltransferase" /protein_id="NP_390966.1" /db_xref="EnsemblGenomes-Gn:BSU30880" /db_xref="EnsemblGenomes-Tr:CAB15066" /db_xref="GOA:O34413" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR028098" /db_xref="SubtiList:BG13830" /db_xref="UniProtKB/Swiss-Prot:O34413" /translation="MKLAFICTEKLPAPAVRGGAIQMMIDGVTPYFSSRYDLTIFSIE DPSLPKRETKDGVHYIHLPKEHYREAVAEELRASSFDLIHVFNRPLNVSLYKKASPNS KIVLSLHNEMFSEKKMTFAQGKEVLDNVSMITTVSEFIKQTVIERFPEAEDITKVVYS GVDLNSYPPVWTMKGSAVRKTYRKKYGIEDKKVILFAGRLSPTKGPHLLIHSMRRILQ QHPDAVLVIAGGKWFSDDSENQYVTYLRTLALPYRDHIIFTKFIPADDIPNLFLMADV FVCSSQWNEPLARVNYEAMAAGTPLITTNRGGNGEVVKHEVTGLVIDSYNKPSSFAKA IDRAFTDQELMNKMTKNARKHVEALFTFTHAAKRLNTVYQSVLTPKNKQFPPPFLTQN FDLSSINQLFVKAKT*" /label="ytcC CDS" gene 2809076..2810299 /gene="ytcC" /locus_tag="BSU_30880" /old_locus_tag="BSU30880" /label="ytcC gene" downshifts complement(2810223) /Source="Nicolas_upshifts" /id="D1589" /incds=1 /nref=1 /ntot=10 /MaxReadThrough="1.32025" /MaxDrop="3.47267" /score="-3.65321449" /energy="-3.1" /TU="NA" /idTUdmin="U2395" /TUdmin=66 /isTUend="FALSE" /label="downshifts" S_feature 2810300..2810867 /Source="Nicolas_S_feature" /locus_tag="new_3159185_3159752" /HighExp="S8, S7, BT, S6, C30, Pyr, S5, G/S, C90, Glucon" /AntisenseName="ytxO" /AntisenseCor="0.86121563743373297" /AntisenseRegPval="-79.7" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.99" /TUlongSig="NA" /TUlongPSig="NA" /label="S1179" CDS complement(2810373..2810804) /gene="cotOO" /locus_tag="BSU_30890" /old_locus_tag="BSU30890" /experiment="publication(s) with functional evidences, PMID:19933362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19933362; Product type s: structure" /codon_start=1 /transl_table=11 /product="outer spore coat protein" /protein_id="NP_390967.1" /db_xref="EnsemblGenomes-Gn:BSU30890" /db_xref="EnsemblGenomes-Tr:CAB15067" /db_xref="SubtiList:BG11382" /db_xref="UniProtKB/Swiss-Prot:P46916" /translation="MRSSRQKASISKLDLDQFVFTPPGPMGWQAHDSISAEKEEEEKH LDVGSIRELPHINAPKEYQKETKEKETDRKIVDDEEETKFETTLEPEEERDSKRSAPP YEEEDEDEEPDLAEEAKVEIIILPSESKPAPWFSQTVKRKA*" /label="cotOO CDS" gene complement(2810373..2810804) /gene="cotOO" /locus_tag="BSU_30890" /old_locus_tag="BSU30890" /label="cotOO gene" downshifts complement(2810399) /Source="Nicolas_upshifts" /id="D1590" /incds=0 /nref=11 /ntot=36 /MaxReadThrough="3.07378" /MaxDrop="4.8822" /score="9.30990044" /energy="-8.3" /TU="U2395" /idTUdmin="U2395" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" CDS complement(2810806..2811861) /gene="cotS" /locus_tag="BSU_30900" /old_locus_tag="BSU30900" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:7545510, 9603889, 10234840, 11737650, 14702409" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7545510, 9603889, 10234840, 11737650, 14702409; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat protein" /protein_id="NP_390968.1" /db_xref="EnsemblGenomes-Gn:BSU30900" /db_xref="EnsemblGenomes-Tr:CAB15068" /db_xref="GOA:P46914" /db_xref="InterPro:IPR011009" /db_xref="InterPro:IPR014255" /db_xref="SubtiList:BG11380" /db_xref="UniProtKB/Swiss-Prot:P46914" /translation="MYQKEHEEQIVSEILSYYPFHIDHVALKSNKSGRKIWEVETDHG PKLLKEAQMKPERMLFITQAHAHLQEKGLPIAPIHQTKNGGSCLGTDQVSYSLYDKVT GKEMIYYDAEQMKKVMSFAGHFHHASKGYVCTDESKKRSRLGKWHKLYRWKLQELEGN MQIAASYPDDVFSQTFLKHADKMLARGKEALRALDDSEYETWTKETLEHGGFCFQDFT LARLTEIEGEPFLKELHSITYDLPSRDLRILLNKVMVKLSVWDTDFMVALLAAYDAVY PLTEKQYEVLWIDLAFPHLFCAIGHKYYLKQKKTWSDEKYNWALQNMISVEESKDSFL DKLPELYKKIKAYREAN*" /label="cotS CDS" gene complement(2810806..2811861) /gene="cotS" /locus_tag="BSU_30900" /old_locus_tag="BSU30900" /label="cotS gene" CDS complement(2811876..2813009) /gene="cotSA" /locus_tag="BSU_30910" /old_locus_tag="BSU30910" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9603889, 10234840, 11737650" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9603889, 10234840, 11737650; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat protein" /protein_id="NP_390969.1" /db_xref="EnsemblGenomes-Gn:BSU30910" /db_xref="EnsemblGenomes-Tr:CAB15069" /db_xref="GOA:P46915" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR028098" /db_xref="SubtiList:BG11381" /db_xref="UniProtKB/Swiss-Prot:P46915" /translation="MKIALIATEKLPVPSVRGGAIQIYLEAVAPLIAKKHEVTVFSIK DPNLADREKVDGVHYVHLDEDRYEEAVGAELKKSRFDLVHVCNRPSWVPKLKKQAPDA VFILSVHNEMFAYDKISQAEGEICIDSVAQIVTVSDYIGQTITSRFPSARSKTKTVYS GVDLKTYHPRWTNEGQRAREEMRSELGLHGKKIVLFVGRLSKVKGPHILLQALPDIIE EHPDVMMVFIGSKWFGDNELNNYVKHLHTLGAMQKDHVTFIQFVKPKDIPRLYTMSDV FVCSSQWQEPLARVHYEAMAAGLPIITSNRGGNPEVIEEGKNGYIIHDFENPKQYAER INDLLSSSEKRERLGKYSRREAESNFGWQRVAENLLSVYEKNR*" /label="cotSA CDS" gene complement(2811876..2813009) /gene="cotSA" /locus_tag="BSU_30910" /old_locus_tag="BSU30910" /label="cotSA gene" promotor_-10 complement(2813042..2813061) /Source="Nicolas_upshift_promotors" /id="U2395" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1345 /SigmaFactorBS="tctggttgtttacccgttttgtttttagggcagtcccaTTCC GCACAAgttggttgttcaGCCGTATCATGATTCTAACTagttaaaaatcatgcaggaa t" /listShort="cotSA, cotS, ytxO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2813061) /Source="Nicolas_upshifts" /id="U2395" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1345 /SigmaFactorBS="tctggttgtttacccgttttgtttttagggcagtcccaTTCC GCACAAgttggttgttcaGCCGTATCATGATTCTAACTagttaaaaatcatgcaggaa t" /listShort="cotSA, cotS, ytxO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2813074..2813083) /Source="Nicolas_upshift_promotors" /id="U2395" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1345 /SigmaFactorBS="tctggttgtttacccgttttgtttttagggcagtcccaTTCC GCACAAgttggttgttcaGCCGTATCATGATTCTAACTagttaaaaatcatgcaggaa t" /listShort="cotSA, cotS, ytxO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2813147..2813156 /Source="Nicolas_upshift_promotors" /id="U2396" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1346 /SigmaFactorBS="aacaaccagattcatctattaaatatagtcaaataACTCAAT CATtttttccttttgaTTCATAAGGTAGGAGTAAAAcaggtaaggatgtgtcctttaa t" /listShort="cotI, ytaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2813170..2813189 /Source="Nicolas_upshift_promotors" /id="U2396" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1346 /SigmaFactorBS="aacaaccagattcatctattaaatatagtcaaataACTCAAT CATtttttccttttgaTTCATAAGGTAGGAGTAAAAcaggtaaggatgtgtcctttaa t" /listShort="cotI, ytaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2813172 /Source="Nicolas_upshifts" /id="U2396" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1346 /SigmaFactorBS="aacaaccagattcatctattaaatatagtcaaataACTCAAT CATtttttccttttgaTTCATAAGGTAGGAGTAAAAcaggtaaggatgtgtcctttaa t" /listShort="cotI, ytaB" /GFF_Attribute="listLong" /label="upshifts" CDS 2813199..2814272 /gene="cotI" /locus_tag="BSU_30920" /old_locus_tag="BSU30920" /function="16.13: Shape" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12562816, 20077512" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12562816, 20077512; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore coat kinase" /protein_id="NP_390970.1" /db_xref="EnsemblGenomes-Gn:BSU30920" /db_xref="EnsemblGenomes-Tr:CAB15070" /db_xref="GOA:O34656" /db_xref="InterPro:IPR002575" /db_xref="InterPro:IPR011009" /db_xref="InterPro:IPR014255" /db_xref="PDB:2Q83" /db_xref="SubtiList:BG13821" /db_xref="UniProtKB/Swiss-Prot:O34656" /translation="MCPLMAENHEVIEEGNSSELPLSAEDAKKLTELAENVLQGWDVQ AEKIDVIQGNQMALVWKVHTDSGAVCLKRIHRPEKKALFSIFAQDYLAKKGMNVPGIL PNKKGSLYSKHGSFLFVVYDWIEGRPFELTVKQDLEFIMKGLADFHTASVGYQPPNGV PIFTKLGRWPNHYTKRCKQMETWKLMAEAEKEDPFSQLYLQEIDGFIEDGLRIKDRLL QSTYVPWTEQLKKSPNLCHQDYGTGNTLLGENEQIWVIDLDTVSFDLPIRDLRKMIIP LLDTTGVWDDETFNVMLNAYESRAPLTEEQKQVMFIDMLFPYELYDVIREKYVRKSAL PKEELESAFEYERIKANALRQLI*" /label="cotI CDS" gene 2813199..2814272 /gene="cotI" /locus_tag="BSU_30920" /old_locus_tag="BSU30920" /label="cotI gene" promotor_-35 2813496..2813502 /Source="Nicolas_upshift_promotors" /id="U2397" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=785 /SigmaFactorBS="tttcgcgcaggactatttagcaaaaaaaggcatgaatgttcc tGGCATACtcccaaacaaaaaAGGCAGCCTATAttctaagcacggctcatttctattt g" /listShort="ytaB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2813513 /Source="Nicolas_upshifts" /id="U2397" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=785 /SigmaFactorBS="tttcgcgcaggactatttagcaaaaaaaggcatgaatgttcc tGGCATACtcccaaacaaaaaAGGCAGCCTATAttctaagcacggctcatttctattt g" /listShort="ytaB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2813516..2813527 /Source="Nicolas_upshift_promotors" /id="U2397" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=785 /SigmaFactorBS="tttcgcgcaggactatttagcaaaaaaaggcatgaatgttcc tGGCATACtcccaaacaaaaaAGGCAGCCTATAttctaagcacggctcatttctattt g" /listShort="ytaB" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 2814261 /Source="Nicolas_upshifts" /id="D1591" /incds=0 /nref=16 /ntot=35 /MaxReadThrough="3.14769" /MaxDrop="5.1897" /score="-2.47616606" /energy="-10.3" /TU="U2396,U2397" /idTUdmin="U2396" /TUdmin="-528" /isTUend="FALSE" /label="downshifts" promotor_-35 2814299..2814305 /Source="Nicolas_upshift_promotors" /id="U2398" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=240 /SigmaFactorBS="gcagcttatttaagaccatcatttcccccgcatatcgggGGT TTGAtatttataagataaaGGGTAATTAAATACATGCGgaggttgcaaatatgaaaaa g" /listShort="ytaB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2814320 /Source="Nicolas_upshifts" /id="U2398" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=240 /SigmaFactorBS="gcagcttatttaagaccatcatttcccccgcatatcgggGGT TTGAtatttataagataaaGGGTAATTAAATACATGCGgaggttgcaaatatgaaaaa g" /listShort="ytaB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2814321..2814339 /Source="Nicolas_upshift_promotors" /id="U2398" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=240 /SigmaFactorBS="gcagcttatttaagaccatcatttcccccgcatatcgggGGT TTGAtatttataagataaaGGGTAATTAAATACATGCGgaggttgcaaatatgaaaaa g" /listShort="ytaB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2814352..2814819 /gene="ytaB" /locus_tag="BSU_30930" /old_locus_tag="BSU30930" /function="16.12: Sense" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11717291, 15849754, 16850406; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="putative receptor" /protein_id="NP_390971.1" /db_xref="EnsemblGenomes-Gn:BSU30930" /db_xref="EnsemblGenomes-Tr:CAB15071" /db_xref="GOA:O34694" /db_xref="InterPro:IPR004307" /db_xref="SubtiList:BG13822" /db_xref="UniProtKB/Swiss-Prot:O34694" /translation="MKKIVGALAVFVITYALFSAAGYLFPVDQEWYNSLKKPDWTPSG TAIGIIWAILFALISLSAAIVYAAFSFKGAKSFWFTLLINYVLNQAFSYFQFTQKNLL AASLDCLLVAITAIVLLIIAKKYSRAASYLLLPYFLWSAFATFLSFTINSMNL*" /label="ytaB CDS" gene 2814352..2814819 /gene="ytaB" /locus_tag="BSU_30930" /old_locus_tag="BSU30930" /label="ytaB gene" downshifts 2814791 /Source="Nicolas_upshifts" /id="D1592" /incds=0 /nref=43 /ntot=123 /MaxReadThrough="2.47485" /MaxDrop="5.7907" /score="9.10214462" /energy="-10.1" /TU="NA" /idTUdmin="U2396" /TUdmin=2 /isTUend="TRUE" /label="downshifts" CDS complement(2814850..2817246) /gene="glgP" /locus_tag="BSU_30940" /old_locus_tag="BSU30940" /EC_number="2.4.1.1" /function="16.14: Store" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 8145641, 9244254, 15272305; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycogen phosphorylase" /protein_id="NP_390972.1" /db_xref="EnsemblGenomes-Gn:BSU30940" /db_xref="EnsemblGenomes-Tr:CAB15072" /db_xref="GOA:P39123" /db_xref="InterPro:IPR000811" /db_xref="InterPro:IPR011833" /db_xref="InterPro:IPR035090" /db_xref="SubtiList:BG10911" /db_xref="UniProtKB/Swiss-Prot:P39123" /translation="MFSSKERFADLFLKRLEMTCGKSFKDSAKLDQYKTLGNMVREYI SADWIETNEKSRSNSGKQTYYLSIEFLLGQLLEQNLMNLGVRDVVEAGLKEIGINLEE ILQIENDAGLGNGGLGRLAACFLDSLASLNLPGHGMGIRYKHGLFEQKIVDGHQVELP EQWLKNGNVWEVRNADQAVDVPFWGEVHMTEKSGRLHFRHEQATIVTAVPYDIPIIGY ETGTVNTLRLWNAEPYAHYHGGNILSYKRETEAVSEFLYPDDTHDEGKILRLKQQYFL VCASLKSIVNNYRKTHKSLSGLHKKVSIHINDTHPALAVPELMRILLDEENMSWEEAW HITVHTISYTNHTTLSEALEKWPIHLFKPLLPRMYMIIEEINERFCRAVWEKYPGDWK RIENMAITAHGVVKMAHLAIVGSYSVNGVAKIHSDILKEREMRDFHLLFPNRFNNKTN GIAHRRWLLKANPGLSAIITEAIGDEWVKQPESLIRLEPYATDPAFIEQFQNNKSKKK QELADLIFCTAGVVVNPESIFDVQVKRLHAYKRQLLNVLHIMYLYNRLKEDSGFSIYP QTFIFGAKASPSYYYAKKIIKLIHSVAEKVNYDPAVKQLIKVVFLENYRVSMAERIFP ASDVSEQISTASKEASGTGNMKFMMNGALTIGTHDGANIEILERVGPDCIYTFGLKAD EVLSYQENGGYRSREYYQHDRRIRQVADQLINGFFEGEADEFESIFDSLLPHNDEYFV LKDFSSYADAQERIQADYRERRKWSEHSIVNIAHSGYFSSDRTIREYAKDIWGIKPMM *" /label="glgP CDS" gene complement(2814850..2817246) /gene="glgP" /locus_tag="BSU_30940" /old_locus_tag="BSU30940" /label="glgP gene" downshifts complement(2814865) /Source="Nicolas_upshifts" /id="D1593" /incds=0 /nref=6 /ntot=43 /MaxReadThrough="2.31076" /MaxDrop="4.39135" /score="34.694666" /energy="-10.1" /TU="NA" /idTUdmin="U2399" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2817233..2818687) /gene="glgA" /locus_tag="BSU_30950" /old_locus_tag="BSU30950" /EC_number="2.4.1.21" /function="16.14: Store" /experiment="publication(s) with functional evidences, PMID:8145641, 15272305" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8145641, 15272305; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycogen (starch) synthase" /protein_id="NP_390973.1" /db_xref="EnsemblGenomes-Gn:BSU30950" /db_xref="EnsemblGenomes-Tr:CAB15073" /db_xref="GOA:P39125" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR011835" /db_xref="InterPro:IPR013534" /db_xref="SubtiList:BG10910" /db_xref="UniProtKB/Swiss-Prot:P39125" /translation="MKILFAVSECTPFVKSGGLADVAGALPKALARLGNEVAVMLPKY SQIPEPWKKRMKKQAECTVAVGWRQQYCGIEHMAENDVNYYFIDNEYYFNRDSLYGHY DDGERFAFFSRAVLEAAKVVNVQADIVHTHDWHTAMVNYLLKEEYRKHPFYERMKSVL TIHNLQFQGIFPPDVTHDLLGLEMDHFHYERLECNGFVNFMKAGIIAADHVTTVSPTY RNEIMTPYYGEQLEQVLQYREDDVTGILNGIDDTFYQPKSDPYIEAQYDSGDLACKLE NKTKLQQRMGLPEKNDIPLISMVTRLTKQKGLDLVRRIMHELLEEQDIQLVVLGTGER EFEDYFRYAEFAFHEKCRAYIGFDEPLAHQIYAGSDMFLMPSKFEPCGLGQLIALQYG AIPIVRETGGLYDTVRAYQEEEGTGNGFTFSAFNAHDLKFTIERALSFYCQQDVWKSI VKTAMNADYSWGKSAKEYQRIFEQVTRSGRDVLE*" /label="glgA CDS" gene complement(2817233..2818687) /gene="glgA" /locus_tag="BSU_30950" /old_locus_tag="BSU30950" /label="glgA gene" CDS complement(2818684..2819715) /gene="glgD" /locus_tag="BSU_30960" /old_locus_tag="BSU30960" /EC_number="2.7.7.27" /function="16.14: Store" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8145641, 9244254; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucose-1-phosphate adenylyltransferase (ADP-glucose pyrophosphorylase) beta subunit" /protein_id="NP_390974.1" /db_xref="EnsemblGenomes-Gn:BSU30960" /db_xref="EnsemblGenomes-Tr:CAB15074" /db_xref="GOA:P39124" /db_xref="InterPro:IPR005835" /db_xref="InterPro:IPR011004" /db_xref="InterPro:IPR011832" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG10909" /db_xref="UniProtKB/Swiss-Prot:P39124" /translation="MFNNQMLGVIDETTYKHSLQDLTAQRSLGAIPFAGRYRLIDFML SNMVNADIRSVAIFPKYRYRSLMDHLGAGKEWDLHRKKDGLFFFPSPHLHHEYDEFGS FRQFSDHLDYFHRSTQQYAVISNSHTVCNIQFQYVLKRHQEVGCDVTEVFQDGQSLQI YIMSTTLLKDLIYGHSEKGYKTIQEAVEKESSALTICPYEYSGYAAVIDSVEKYYTHS MELIQPRFWQQVFLPQQPIYTKVKDEPPTKYGKHSTVKNSLVANGCVLEGEVENCILF RAVHVGKGTKLKNCIIMQKTQIGEDCLLEQVISDKDVKIGKATEAAGTAEQPLVLRKG LVQGELMNS*" /label="glgD CDS" gene complement(2818684..2819715) /gene="glgD" /locus_tag="BSU_30960" /old_locus_tag="BSU30960" /label="glgD gene" CDS complement(2819739..2820881) /gene="glgC" /locus_tag="BSU_30970" /old_locus_tag="BSU30970" /EC_number="2.7.7.27" /function="16.14: Store" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8145641, 9244254; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucose-1-phosphate adenylyltransferase (ADP-glucose pyrophosphorylase) subunit alpha" /protein_id="NP_390975.1" /db_xref="EnsemblGenomes-Gn:BSU30970" /db_xref="EnsemblGenomes-Tr:CAB15075" /db_xref="GOA:P39122" /db_xref="InterPro:IPR005835" /db_xref="InterPro:IPR005836" /db_xref="InterPro:IPR011004" /db_xref="InterPro:IPR011831" /db_xref="InterPro:IPR023049" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG10908" /db_xref="UniProtKB/Swiss-Prot:P39122" /translation="MKKQCVAMLLAGGKGSRLSGLTKNMAKPAVSFGGKYRIIDFTLS NCSNSGIDTVGILTQYQPLELNSYIGIGSAWDLDRYNGGVTVLPPYAESSEVKWYKGT ASSIYENLNYLNQYDPEYVLILSGDHIYKMDYGKMLDYHIEKKADVTISVIEVGWEEA SRFGIMKANPDGTITHFDEKPKFPKSNLASMGIYIFNWPLLKQYLEMDDQNPYSSHDF GKDIIPLLLEEKKKLSAYPFKGYWKDVGTVQSLWEANMDLLKEDSELKLFERKWKIYS VNPNQPPQFISSDAQVQDSLVNEGCVVYGNVSHSVLFQGVTVGKHTTVTSSVIMPDVT IGEHVVIENAIVPNGMVLPDGAVIRSEKDIEEVLLVSEEFVEKELI*" /label="glgC CDS" gene complement(2819739..2820881) /gene="glgC" /locus_tag="BSU_30970" /old_locus_tag="BSU30970" /label="glgC gene" CDS complement(2820878..2822761) /gene="glgB" /locus_tag="BSU_30980" /old_locus_tag="BSU30980" /EC_number="2.4.1.18" /function="16.14: Store" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1296817, 15272305, 8145641; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="1,4-alpha-glucan branching enzyme" /protein_id="NP_390976.1" /db_xref="EnsemblGenomes-Gn:BSU30980" /db_xref="EnsemblGenomes-Tr:CAB15076" /db_xref="GOA:P39118" /db_xref="InterPro:IPR004193" /db_xref="InterPro:IPR006047" /db_xref="InterPro:IPR006048" /db_xref="InterPro:IPR006407" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR014756" /db_xref="InterPro:IPR017853" /db_xref="SubtiList:BG10907" /db_xref="UniProtKB/Swiss-Prot:P39118" /translation="MAAASPTAHDVYLFHEGSLFKSYQLFGSHYRELNGKSGYEFCVW APHASEVRVAGDFNSWSGEEHVMHRVNDNGIWTLFIPGIGEKERYKYEIVTNNGEIRL KADPYAIYSEVRPNTASLTYDLEGYSWQDQKWQKKQKAKTLYEKPVFIYELHLGSWKK HSDGRHYSYKELSQTLIPYIKKHGFTHIELLPVYEHPYDRSWGYQGTGYYSPTSRFGP PHDLMKFVDECHQQNIGVILDWVPGHFCKDAHGLYMFDGEPLYEYKEERDRENWLWGT ANFDLGKPEVHSFLISNALYWAEFYHIDGFRVDAVANILYWPNQDERHTNPYAVDFLK KLNQTMREAYPHVMMIAEDSTEWPQVTGAVEEGGLGFHYKWNMGWMNDVLKYMETPPE ERRHCHQLISFSLLYAFSEHFVLPFSHDEVVYGKKSLLNKMPGDYWQKFAQYRLLLGY MTVHPGKKLIFMGSEFAQFDEWKDTEQLDWFLDSFPMHQKASVFTQDLLRFYQKSKIL YEHDHRAQSFEWIDVHNDEQSIFSFIRYGQKHGEALVIICNFTPVVYHQYDVGVPFFT QYIEVLNSDSETYGGSGQINKKPLSAKKGALHHKPCYITMTIPPYGISILRAVKKRGE IKR*" /label="glgB CDS" gene complement(2820878..2822761) /gene="glgB" /locus_tag="BSU_30980" /old_locus_tag="BSU30980" /label="glgB gene" S_feature 2821587..2823006 /Source="Nicolas_S_feature" /locus_tag="new_3170472_3171891" /HighExp="S8, S7, S6, C30, BT, Pyr, G/S, S2, C90, BC" /AntisenseName="glgB" /AntisenseCor="0.59299722159013002" /AntisenseRegPval="-26.2" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1180" promotor_-10 complement(2822793..2822808) /Source="Nicolas_upshift_promotors" /id="U2399" /multdbtbs="SigE" /comp="M1" /sig="Sig-" /pcomp="0.414585414585415" /psig="0.414585414585415" /xcortree=1175 /SigmaFactorBS="gaagttaattgtctataagtataagcgctttcaggaaaGGGC TTttttttatttcttcGAATAAATACTATAAAtgaaaactatgatgtcagaaaggatg a" /listShort="glgB, glgC, glgD, glgA, glgP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2822806) /Source="Nicolas_upshifts" /id="U2399" /multdbtbs="SigE" /comp="M1" /sig="Sig-" /pcomp="0.414585414585415" /psig="0.414585414585415" /xcortree=1175 /SigmaFactorBS="gaagttaattgtctataagtataagcgctttcaggaaaGGGC TTttttttatttcttcGAATAAATACTATAAAtgaaaactatgatgtcagaaaggatg a" /listShort="glgB, glgC, glgD, glgA, glgP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2822823..2822828) /Source="Nicolas_upshift_promotors" /id="U2399" /multdbtbs="SigE" /comp="M1" /sig="Sig-" /pcomp="0.414585414585415" /psig="0.414585414585415" /xcortree=1175 /SigmaFactorBS="gaagttaattgtctataagtataagcgctttcaggaaaGGGC TTttttttatttcttcGAATAAATACTATAAAtgaaaactatgatgtcagaaaggatg a" /listShort="glgB, glgC, glgD, glgA, glgP" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2822873) /Source="Nicolas_upshifts" /id="D1594" /incds=0 /nref=2 /ntot=46 /MaxReadThrough="1.66182" /MaxDrop="3.12741" /score="36.0363304" /energy="-9.2" /TU="NA" /idTUdmin="U2401" /TUdmin=198 /isTUend="FALSE" /label="downshifts" tRNA complement(2822994..2823065) /gene="trnB-Glu" /locus_tag="BSU_tRNA_72" /product="tRNA-Glu" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Glu tRNA" gene complement(2822994..2823065) /gene="trnB-Glu" /locus_tag="BSU_tRNA_72" /label="trnB-Glu gene" tRNA complement(2823091..2823181) /gene="trnB-Ser2" /locus_tag="BSU_tRNA_71" /product="tRNA-Ser" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Ser2 tRNA" gene complement(2823091..2823181) /gene="trnB-Ser2" /locus_tag="BSU_tRNA_71" /label="trnB-Ser2 gene" tRNA complement(2823185..2823259) /gene="trnB-Asn" /locus_tag="BSU_tRNA_70" /product="tRNA-Asn" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Asn tRNA" gene complement(2823185..2823259) /gene="trnB-Asn" /locus_tag="BSU_tRNA_70" /label="trnB-Asn gene" tRNA complement(2823270..2823346) /gene="trnB-Ile2" /locus_tag="BSU_tRNA_69" /product="tRNA-Ile" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Ile2 tRNA" gene complement(2823270..2823346) /gene="trnB-Ile2" /locus_tag="BSU_tRNA_69" /label="trnB-Ile2 gene" tRNA complement(2823362..2823435) /gene="trnB-Gly2" /locus_tag="BSU_tRNA_68" /product="tRNA-Gly" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Gly2 tRNA" gene complement(2823362..2823435) /gene="trnB-Gly2" /locus_tag="BSU_tRNA_68" /label="trnB-Gly2 gene" tRNA complement(2823446..2823521) /gene="trnB-His" /locus_tag="BSU_tRNA_67" /product="tRNA-His" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-His tRNA" gene complement(2823446..2823521) /gene="trnB-His" /locus_tag="BSU_tRNA_67" /label="trnB-His gene" tRNA complement(2823539..2823614) /gene="trnB-Phe" /locus_tag="BSU_tRNA_66" /product="tRNA-Phe" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Phe tRNA" gene complement(2823539..2823614) /gene="trnB-Phe" /locus_tag="BSU_tRNA_66" /label="trnB-Phe gene" tRNA complement(2823627..2823703) /gene="trnB-Asp" /locus_tag="BSU_tRNA_65" /product="tRNA-Asp" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Asp tRNA" gene complement(2823627..2823703) /gene="trnB-Asp" /locus_tag="BSU_tRNA_65" /label="trnB-Asp gene" tRNA complement(2823715..2823791) /gene="trnB-Met2" /locus_tag="BSU_tRNA_64" /product="tRNA-Met" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Met2 tRNA" gene complement(2823715..2823791) /gene="trnB-Met2" /locus_tag="BSU_tRNA_64" /label="trnB-Met2 gene" tRNA complement(2823809..2823901) /gene="trnB-Ser1" /locus_tag="BSU_tRNA_63" /product="tRNA-Ser" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Ser1 tRNA" gene complement(2823809..2823901) /gene="trnB-Ser1" /locus_tag="BSU_tRNA_63" /label="trnB-Ser1 gene" tRNA complement(2823908..2823984) /gene="trnB-Met3" /locus_tag="BSU_tRNA_62" /product="tRNA-Met" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Met3 tRNA" gene complement(2823908..2823984) /gene="trnB-Met3" /locus_tag="BSU_tRNA_62" /label="trnB-Met3 gene" tRNA complement(2823987..2824063) /gene="trnB-Met1" /locus_tag="BSU_tRNA_61" /product="tRNA-Met" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Met1 tRNA" gene complement(2823987..2824063) /gene="trnB-Met1" /locus_tag="BSU_tRNA_61" /label="trnB-Met1 gene" tRNA complement(2824083..2824155) /gene="trnB-Ala" /locus_tag="BSU_tRNA_60" /product="tRNA-Ala" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Ala tRNA" gene complement(2824083..2824155) /gene="trnB-Ala" /locus_tag="BSU_tRNA_60" /label="trnB-Ala gene" tRNA complement(2824161..2824237) /gene="trnB-Pro" /locus_tag="BSU_tRNA_59" /product="tRNA-Pro" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Pro tRNA" gene complement(2824161..2824237) /gene="trnB-Pro" /locus_tag="BSU_tRNA_59" /label="trnB-Pro gene" tRNA complement(2824253..2824329) /gene="trnB-Arg" /locus_tag="BSU_tRNA_58" /product="tRNA-Arg" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Arg tRNA" gene complement(2824253..2824329) /gene="trnB-Arg" /locus_tag="BSU_tRNA_58" /label="trnB-Arg gene" tRNA complement(2824339..2824424) /gene="trnB-Leu2" /locus_tag="BSU_tRNA_57" /product="tRNA-Leu" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Leu2 tRNA" gene complement(2824339..2824424) /gene="trnB-Leu2" /locus_tag="BSU_tRNA_57" /label="trnB-Leu2 gene" tRNA complement(2824439..2824513) /gene="trnB-Gly1" /locus_tag="BSU_tRNA_56" /product="tRNA-Gly" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Gly1 tRNA" gene complement(2824439..2824513) /gene="trnB-Gly1" /locus_tag="BSU_tRNA_56" /label="trnB-Gly1 gene" tRNA complement(2824519..2824605) /gene="trnB-Leu1" /locus_tag="BSU_tRNA_55" /product="tRNA-Leu" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Leu1 tRNA" gene complement(2824519..2824605) /gene="trnB-Leu1" /locus_tag="BSU_tRNA_55" /label="trnB-Leu1 gene" tRNA complement(2824616..2824691) /gene="trnB-Lys" /locus_tag="BSU_tRNA_54" /product="tRNA-Lys" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Lys tRNA" gene complement(2824616..2824691) /gene="trnB-Lys" /locus_tag="BSU_tRNA_54" /label="trnB-Lys gene" tRNA complement(2824729..2824804) /gene="trnB-Thr" /locus_tag="BSU_tRNA_53" /product="tRNA-Thr" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Thr tRNA" gene complement(2824729..2824804) /gene="trnB-Thr" /locus_tag="BSU_tRNA_53" /label="trnB-Thr gene" tRNA complement(2824837..2824912) /gene="trnB-Val" /locus_tag="BSU_tRNA_52" /product="tRNA-Val" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnB-Val tRNA" gene complement(2824837..2824912) /gene="trnB-Val" /locus_tag="BSU_tRNA_52" /label="trnB-Val gene" rRNA complement(2824933..2825050) /gene="rrnB-5S" /locus_tag="BSU_rRNA_21" /product="ribosomal RNA-5S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnB-5S rRNA" gene complement(2824933..2825050) /gene="rrnB-5S" /locus_tag="BSU_rRNA_21" /label="rrnB-5S gene" rRNA complement(2825106..2828033) /gene="rrnB-23S" /locus_tag="BSU_rRNA_20" /product="ribosomal RNA-23S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnB-23S rRNA" gene complement(2825106..2828033) /gene="rrnB-23S" /locus_tag="BSU_rRNA_20" /label="rrnB-23S gene" rRNA complement(2828201..2829755) /gene="rrnB-16S" /locus_tag="BSU_rRNA_19" /product="ribosomal RNA-16S" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="rrnB-16S rRNA" gene complement(2828201..2829755) /gene="rrnB-16S" /locus_tag="BSU_rRNA_19" /label="rrnB-16S gene" Polymorphism join(2829557,2829559) /Source="geneious" /ID="SNP_BsDelta6_3178443_3178443" /Polymorphism_Type="SNP (transition)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change /CDS_Position /Change="T -> C" /Codon_Change /Coverage=95 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides="T" /Variant_Nucleotides="C" /Variant_P_Value="3.5e-102" /Variant_Raw_Frequency=94 /comment="rrnB-16S rRNA" /modified_by="User" / /label="Polymorphism_Delta6" S_feature complement(2829756..2830047) /Source="Nicolas_S_feature" /locus_tag="new_3178641_3178932_c" /HighExp="Diami, LPhT, C30, LBGstat, HPh, GM 120, Oxctl, Paraq, LPh, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.40784100000000001" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigWXY" /TUlongPSig=1 /label="S1181" misc_feature 2829883..2829891 /Source="Nicolas_upshift_promotors" /id="U2400" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.413586413586414" /psig="0.320679320679321" /xcortree=710 /SigmaFactorBS="tgactacgcacatcgcagtgcgatttttaaaaactgaattaa caggtacgttttGTCTTGTTTagttttcaaagatcatttcgttacttctcaatgaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2829889 /Source="Nicolas_upshifts" /id="U2400" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.413586413586414" /psig="0.320679320679321" /xcortree=710 /SigmaFactorBS="tgactacgcacatcgcagtgcgatttttaaaaactgaattaa caggtacgttttGTCTTGTTTagttttcaaagatcatttcgttacttctcaatgaagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2829999 /Source="Nicolas_upshifts" /id="D1595" /incds=0 /nref=2 /ntot=26 /MaxReadThrough="2.91899" /MaxDrop="4.63941" /score="-0.368124787" /energy="-10.2" /TU="U2400" /idTUdmin="U2400" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2830020..2830039) /Source="Nicolas_upshift_promotors" /id="U2401" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2621 /SigmaFactorBS="ggcgaggattatagtttatttgttttatagattttttttaaa aaactATTGCAATaaataaatacaggTGTTATATTATTAAACGTCGctgatgcacagc g" /listShort="S1181, rrnB-16S, rrnB-23S, rrnB-5S, trnB-Val, trnB-Thr, trnB-Lys, trnB-Leu1, trnB-Gly1, trnB-Leu2, trnB-Arg, trnB-Pro, trnB-Ala, trnB-Met1, trnB-Met3, trnB-Ser1, trnB-Met2, trnB-Asp, trnB-Phe, trnB-His, trnB-Gly2, trnB-Ile2, trnB-Asn, trnB-Ser2" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2830047) /Source="Nicolas_upshifts" /id="U2401" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2621 /SigmaFactorBS="ggcgaggattatagtttatttgttttatagattttttttaaa aaactATTGCAATaaataaatacaggTGTTATATTATTAAACGTCGctgatgcacagc g" /listShort="S1181, rrnB-16S, rrnB-23S, rrnB-5S, trnB-Val, trnB-Thr, trnB-Lys, trnB-Leu1, trnB-Gly1, trnB-Leu2, trnB-Arg, trnB-Pro, trnB-Ala, trnB-Met1, trnB-Met3, trnB-Ser1, trnB-Met2, trnB-Asp, trnB-Phe, trnB-His, trnB-Gly2, trnB-Ile2, trnB-Asn, trnB-Ser2" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2830049..2831015) /Source="Nicolas_S_feature" /locus_tag="new_3178934_3179900_c" /HighExp="T1.0H, T0.30H, T1.30H, T2.0H, T2.30H, T0.0H, T3.0H, T-0.40H, S8, T3.30H" /AntisenseName="thiT" /AntisenseCor="-0.219467435413819" /AntisenseRegPval="-3.5" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1182" promotor_-35 complement(2830053..2830060) /Source="Nicolas_upshift_promotors" /id="U2401" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2621 /SigmaFactorBS="ggcgaggattatagtttatttgttttatagattttttttaaa aaactATTGCAATaaataaatacaggTGTTATATTATTAAACGTCGctgatgcacagc g" /listShort="S1181, rrnB-16S, rrnB-23S, rrnB-5S, trnB-Val, trnB-Thr, trnB-Lys, trnB-Leu1, trnB-Gly1, trnB-Leu2, trnB-Arg, trnB-Pro, trnB-Ala, trnB-Met1, trnB-Met3, trnB-Ser1, trnB-Met2, trnB-Asp, trnB-Phe, trnB-His, trnB-Gly2, trnB-Ile2, trnB-Asn, trnB-Ser2" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2830172..2830175 /Source="Nicolas_upshift_promotors" /id="U2402" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=1747 /SigmaFactorBS="tatcatataagtttcttaaaagaacatatacatcagtcatgt gatCTTGttgtttttttcgttTTCTTGTATAGTAGAAACGAactaaatactgatgacc a" /listShort="NA, thiT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2830187 /Source="Nicolas_upshifts" /id="U2402" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=1747 /SigmaFactorBS="tatcatataagtttcttaaaagaacatatacatcagtcatgt gatCTTGttgtttttttcgttTTCTTGTATAGTAGAAACGAactaaatactgatgacc a" /listShort="NA, thiT" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2830190..2830209 /Source="Nicolas_upshift_promotors" /id="U2402" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.971028971028971" /psig=1 /xcortree=1747 /SigmaFactorBS="tatcatataagtttcttaaaagaacatatacatcagtcatgt gatCTTGttgtttttttcgttTTCTTGTATAGTAGAAACGAactaaatactgatgacc a" /listShort="NA, thiT" /GFF_Attribute="listLong" /label="promotor_-10" misc_RNA 2830220..2830321 /gene="tswC" /locus_tag="BSU_misc_RNA_51" /product="thiamine pyrophosphate riboswitch" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11470904, 12410317, 15862294, 16728979, 16962976, 17307816, 18179415, 18776013; Product type n: RNA" /function="16.3: Control" /label="tswC RNA" gene 2830220..2830321 /gene="tswC" /locus_tag="BSU_misc_RNA_51" /label="tswC gene" downshifts 2830320 /Source="Nicolas_upshifts" /id="D1596" /incds=0 /nref=47 /ntot=135 /MaxReadThrough="5.85975" /MaxDrop="7.03111" /score="-0.368124787" /energy="-10.2" /TU="U2402" /idTUdmin="U2400" /TUdmin=299 /isTUend="FALSE" /label="downshifts" CDS 2830421..2830999 /gene="thiT" /locus_tag="BSU_30990" /old_locus_tag="BSU30990" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16291685, 16356850, 16850406, 19181806" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16291685, 16356850, 16850406, 19181806; Product type t : transporter" /codon_start=1 /transl_table=11 /product="thiamin permease" /protein_id="NP_390977.1" /db_xref="EnsemblGenomes-Gn:BSU30990" /db_xref="EnsemblGenomes-Tr:CAB15077" /db_xref="GOA:O32074" /db_xref="InterPro:IPR012651" /db_xref="SubtiList:BG13949" /db_xref="UniProtKB/Swiss-Prot:O32074" /translation="MNQSKQLVRLIEIAIMTAAAVILDIVSGMFLSMPQGGSVSIMMI PIFLISFRWGVKAGLTTGLLTGLVQIAIGNLFAQHPVQLLLDYIVAFAAIGISGCFAS SVRKAAVSKTKGKLIVSVVSAVFIGSLLRYAAHVISGAVFFGSFAPKGTPVWIYSLTY NATYMVPSFIICAIVLCLLFMTAPRLLKSDKA*" /label="thiT CDS" gene 2830421..2830999 /gene="thiT" /locus_tag="BSU_30990" /old_locus_tag="BSU30990" /label="thiT gene" downshifts 2830989 /Source="Nicolas_upshifts" /id="D1597" /incds=0 /nref=129 /ntot=206 /MaxReadThrough="1.91553" /MaxDrop="5.49387" /score="35.5376279" /energy="-19.5" /TU="NA" /idTUdmin="U2402" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2831041..2831562) /gene="yuaI" /locus_tag="BSU_31000" /old_locus_tag="BSU31000" /EC_number="2.3.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_390978.1" /db_xref="EnsemblGenomes-Gn:BSU31000" /db_xref="EnsemblGenomes-Tr:CAB15078" /db_xref="GOA:O32075" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG13948" /db_xref="UniProtKB/Swiss-Prot:O32075" /translation="MVTVREAKLEDIKDIAKVHVDSWRTTYHEIIPIDYLNSLNYKEF EDKWKSRSLKGVFVAQDEKGSVFGFASFGPIRSEQEGYDGELYAIYLLEERQRQGAGR ALLAKGAEFLLQHGFSSMFVWVIEQNPSIIFYQAYSPERVAEDNFEIAGVRLKEVGLG WPDLSALKTLLNR*" /label="yuaI CDS" gene complement(2831041..2831562) /gene="yuaI" /locus_tag="BSU_31000" /old_locus_tag="BSU31000" /label="yuaI gene" downshifts complement(2831059) /Source="Nicolas_upshifts" /id="D1598" /incds=0 /nref=8 /ntot=143 /MaxReadThrough="6.18352" /MaxDrop="5.43101" /score="13.1646679" /energy="-19.6" /TU="U2403" /idTUdmin="U2405" /TUdmin=6 /isTUend="TRUE" /label="downshifts" downshifts complement(2831131) /Source="Nicolas_upshifts" /id="D1599" /incds=1 /nref=8 /ntot=208 /MaxReadThrough="8.2849" /MaxDrop="3.3545" /score="13.1646679" /energy="-19.6" /TU="U2403,U2405" /idTUdmin="U2405" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" CDS complement(2831580..2833109) /gene="floT" /locus_tag="BSU_31010" /old_locus_tag="BSU31010" /experiment="publication(s) with functional evidences, PMID:9153235, 9987136, 12533473, 17482313, 19383680, 25635948, 26297017, 28681845" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9153235, 9987136, 12533473, 17482313, 19383680, 25635948, 26297017, 28681845; Product type s: structure" /codon_start=1 /transl_table=11 /product="flotillin lipid rafts scaffold protein" /protein_id="NP_390979.1" /db_xref="EnsemblGenomes-Gn:BSU31010" /db_xref="EnsemblGenomes-Tr:CAB15079" /db_xref="GOA:O32076" /db_xref="InterPro:IPR001107" /db_xref="InterPro:IPR027705" /db_xref="InterPro:IPR031905" /db_xref="InterPro:IPR036013" /db_xref="SubtiList:BG13947" /db_xref="UniProtKB/Swiss-Prot:O32076" /translation="MTMPIIMIIGVVFFLLIALIAVFITKYRTAGPDEALIVTGSYLG NKNVHVDEGGNRIKIVRGGGTFVLPVFQQAEPLSLLSSKLDVSTPEVYTEQGVPVMAD GTAIIKIGGSIGEIATAAEQFLGKSKDDREQEAREVLEGHLRSILGSMTVEEIYKNRE KFSQEVQRVASQDLAKMGLVIVSFTIKDVRDKNGYLESLGKPRIAQVKRDADIATAEA DKETRIKRAEADKDAKKSELERATEIAEAEKINQLKMAEFRREQDTAKANADQAYDLE TARARQQVTEQEMQVKIIERQKQIELEEKEILRRERQYDSEVKKKADADRYSVEQSAA AEKAKQLAEADAKKYSIEAMAKAEAEKVRIDGLAKAEAEKAKGETEAEVIRLKGLAEA EAKEKIAAAFEQYGQAAIFDMIVKMLPEYAKQAAAPLSNIDKITVVDTGGSGESSGAN KVTSYATNLMSSLQESLKASSGIDVKEMLENFSGKGNVKQSINELTNEIKEAKTIQKS E*" /label="floT CDS" gene complement(2831580..2833109) /gene="floT" /locus_tag="BSU_31010" /old_locus_tag="BSU31010" /label="floT gene" CDS complement(2833130..2833654) /gene="nfeDB" /locus_tag="BSU_31020" /old_locus_tag="BSU31020" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12533473, 15849754, 16850406, 18696230, 22753055; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative membrane integrity integral membrane protein" /protein_id="NP_390980.1" /db_xref="EnsemblGenomes-Gn:BSU31020" /db_xref="EnsemblGenomes-Tr:CAB15080" /db_xref="GOA:O32077" /db_xref="PDB:2K14" /db_xref="SubtiList:BG13946" /db_xref="UniProtKB/Swiss-Prot:O32077" /translation="MELFGVPIQTMYLYTLIIAGSLTLLFLFFGDVFSGLSEGIPFLN PTLVLSFFTCFSAGGYIGELVLPLSSLLIALLSCILSIMLVVLLHIFVLVPLSSAEES LAYREDDLRGRLGKVITAVPVDGFGEVVIEGIGGTISKSAVSFDNQQISYGTTVLVVD INNGVLSVTPHEPI*" /label="nfeDB CDS" gene complement(2833130..2833654) /gene="nfeDB" /locus_tag="BSU_31020" /old_locus_tag="BSU31020" /label="nfeDB gene" promotor_-10 complement(2833698..2833713) /Source="Nicolas_upshift_promotors" /id="U2403" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1691 /SigmaFactorBS="acttcaaatgggttatttgtcttaaaatttTGAAACTTTTcc cgaggtgtcTCGTATAAATGGTAACggcagccgttcatcaatgcattgatgaagaaag g" /listShort="yuaF, yuaG, yuaI, S1182" /listLong="S1181" /label="promotor_-10" upshifts complement(2833704) /Source="Nicolas_upshifts" /id="U2403" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1691 /SigmaFactorBS="acttcaaatgggttatttgtcttaaaatttTGAAACTTTTcc cgaggtgtcTCGTATAAATGGTAACggcagccgttcatcaatgcattgatgaagaaag g" /listShort="yuaF, yuaG, yuaI, S1182" /listLong="S1181" /label="upshifts" S_feature complement(2833706..2833793) /Source="Nicolas_S_feature" /locus_tag="new_3182591_3182678_c" /HighExp="S4, S8, S6, S7, S5, S3, B36, LoTm, B60, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.96" /TUlongSig="NA" /TUlongPSig="NA" /label="S1183" promotor_-35 complement(2833725..2833734) /Source="Nicolas_upshift_promotors" /id="U2403" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1691 /SigmaFactorBS="acttcaaatgggttatttgtcttaaaatttTGAAACTTTTcc cgaggtgtcTCGTATAAATGGTAACggcagccgttcatcaatgcattgatgaagaaag g" /listShort="yuaF, yuaG, yuaI, S1182" /listLong="S1181" /label="promotor_-35" promotor_-10 complement(2833778..2833796) /Source="Nicolas_upshift_promotors" /id="U2405" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=1070 /SigmaFactorBS="gtttctaatctggcttcattaaagatactcatcatatCTCCT CctaaaatgacattaCCATATATATAAGCAATTAtcatttataaagcacttcaaatgg g" /listShort="S1183, yuaF, yuaG, yuaI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2833788 /Source="Nicolas_upshifts" /id="U2404" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.442557442557443" /psig="0.962037962037962" /xcortree=633 /SigmaFactorBS="agtttcaaaattttaagacaaataacccatttgaagtgcttt ataaatgataattgcttatataTATGGTAATGTCATTTTAGGaggagatatgatgagt a" /listShort="yuaE, S1184" /GFF_Attribute="listLong" /label="upshifts" misc_feature 2833792..2833811 /Source="Nicolas_upshift_promotors" /id="U2404" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.442557442557443" /psig="0.962037962037962" /xcortree=633 /SigmaFactorBS="agtttcaaaattttaagacaaataacccatttgaagtgcttt ataaatgataattgcttatataTATGGTAATGTCATTTTAGGaggagatatgatgagt a" /listShort="yuaE, S1184" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2833793) /Source="Nicolas_upshifts" /id="U2405" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=1070 /SigmaFactorBS="gtttctaatctggcttcattaaagatactcatcatatCTCCT CctaaaatgacattaCCATATATATAAGCAATTAtcatttataaagcacttcaaatgg g" /listShort="S1183, yuaF, yuaG, yuaI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2833811..2833816) /Source="Nicolas_upshift_promotors" /id="U2405" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.96003996003996" /psig="0.96003996003996" /xcortree=1070 /SigmaFactorBS="gtttctaatctggcttcattaaagatactcatcatatCTCCT CctaaaatgacattaCCATATATATAAGCAATTAtcatttataaagcacttcaaatgg g" /listShort="S1183, yuaF, yuaG, yuaI" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2833822..2834310 /gene="yuaE" /locus_tag="BSU_31030" /old_locus_tag="BSU31030" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390981.1" /db_xref="EnsemblGenomes-Gn:BSU31030" /db_xref="EnsemblGenomes-Tr:CAB15081" /db_xref="InterPro:IPR024775" /db_xref="InterPro:IPR034660" /db_xref="SubtiList:BG13945" /db_xref="UniProtKB/Swiss-Prot:O32078" /translation="MSIFNEARLETWNELKGLSDEKLNQKPSAEEWSIREVLDHLKKI DMTAQKMLKERVKDAPIKEIEEKPLEVAQDRNNKRKAPSHLEPAHDFISGSQMKRELD VVREQLTAAIASLKEEDFERVLPHPVFQELTVRQWIDFIGHHEKRHLSQMKEIKEKIE RA*" /label="yuaE CDS" gene 2833822..2834310 /gene="yuaE" /locus_tag="BSU_31030" /old_locus_tag="BSU31030" /label="yuaE gene" downshifts 2834287 /Source="Nicolas_upshifts" /id="D1600" /incds=0 /nref=205 /ntot=267 /MaxReadThrough="4.05856" /MaxDrop="6.05192" /score="-4.20632485" /energy="-15" /TU="U2404" /idTUdmin="U2404" /TUdmin="-354" /isTUend="FALSE" /label="downshifts" CDS complement(2834316..2834894) /gene="yuaD" /locus_tag="BSU_31040" /old_locus_tag="BSU31040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11886751" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390982.1" /db_xref="EnsemblGenomes-Gn:BSU31040" /db_xref="EnsemblGenomes-Tr:CAB15082" /db_xref="GOA:O32079" /db_xref="InterPro:IPR005302" /db_xref="InterPro:IPR011037" /db_xref="PDB:1ORU" /db_xref="SubtiList:BG13944" /db_xref="UniProtKB/Swiss-Prot:O32079" /translation="MWKRMTAKAEGLYIADTKSFVTKQMDKLDFDYGGIPGDLHFGLT KKAGAREPMFSRGTEIFNRRQISIVSIEECNEIALKMGVPRILPEWLGANVAVSGMPD LTSLKEGSRIIFPSGAALLCEGENDPCIQPGEVIQSYYPDQPKLASAFVRHALGIRGI VCIVERPGAVYTGDEIEVHSYQRKVKRKAERV*" /label="yuaD CDS" gene complement(2834316..2834894) /gene="yuaD" /locus_tag="BSU_31040" /old_locus_tag="BSU31040" /label="yuaD gene" S_feature 2834332..2834723 /Source="Nicolas_S_feature" /locus_tag="new_3183217_3183608" /HighExp="Etha, S8, LPhT, S6, Salt, LoTm, S5, H2O2, S7, dia5" /AntisenseName="yuaD" /AntisenseCor="-0.48344313728748101" /AntisenseRegPval="-16.399999999999999" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.962" /TUlongSig="NA" /TUlongPSig="NA" /label="S1184" downshifts complement(2834343) /Source="Nicolas_upshifts" /id="D1601" /incds=0 /nref=87 /ntot=222 /MaxReadThrough="0.58189" /MaxDrop="3.9885" /score="0.718873117" /energy="-11.5" /TU="NA" /idTUdmin="U2406" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2834928..2834947) /Source="Nicolas_upshift_promotors" /id="U2406" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.437562437562438" /psig="0.97902097902098" /xcortree=2148 /SigmaFactorBS="gcctaaaacggtataatcaaaatcccgctCCTTTACAgagcg ggatttttTGGGATAATGAAGCATAGGTggaaattttagataagaaggaaggtgccag c" /listShort="yuaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2834937) /Source="Nicolas_upshifts" /id="U2406" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.437562437562438" /psig="0.97902097902098" /xcortree=2148 /SigmaFactorBS="gcctaaaacggtataatcaaaatcccgctCCTTTACAgagcg ggatttttTGGGATAATGAAGCATAGGTggaaattttagataagaaggaaggtgccag c" /listShort="yuaD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2834961..2834968) /Source="Nicolas_upshift_promotors" /id="U2406" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.437562437562438" /psig="0.97902097902098" /xcortree=2148 /SigmaFactorBS="gcctaaaacggtataatcaaaatcccgctCCTTTACAgagcg ggatttttTGGGATAATGAAGCATAGGTggaaattttagataagaaggaaggtgccag c" /listShort="yuaD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2834982..2836190) /gene="gbsB" /locus_tag="BSU_31050" /old_locus_tag="BSU31050" /EC_number="1.1.99.1" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8752328, 22408163" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8752328, 22408163; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="choline dehydrogenase" /protein_id="NP_390983.2" /db_xref="EnsemblGenomes-Gn:BSU31050" /db_xref="EnsemblGenomes-Tr:CAB15083" /db_xref="GOA:P71017" /db_xref="InterPro:IPR001670" /db_xref="InterPro:IPR018211" /db_xref="SubtiList:BG11941" /db_xref="UniProtKB/Swiss-Prot:P71017" /translation="MTLNMKVESMQKFHTFEIPTVIKHGIGAIKHTGEEVAALGVSKA LLVTDPGIYKAGVADPVIESLKEAGIEVVLFNKVEPNPPVRLVNEGSELYKKENCNGL VAVGGGSSMDTAKAIGVEATHEGSVLDYEAADGKKPLENRIPPLTTIPTTAGTGSEVT QWAVITDEEREFKFNTGGPLIAAHLTIIDPELHVSMPPHVTAMTGIDALAHAIECYTM KFAQPITDAVALMAIEYAAHYIKRAFADGEDLEARYGMAQAAMLAGLSYGSESAGAAH AMSQTLGGIIPVAHGQCVAAMMGPVMEYNWKGYPEKFARIAKAFGIDTSKMTTEEAAK ASVNWMYDLVEDLEVPTLEEQGVSPDMIERLSKEAMKDPQTFGNPRDLNEKAYNWIYK RCFNLTPKTV*" /label="gbsB CDS" gene complement(2834982..2836190) /gene="gbsB" /locus_tag="BSU_31050" /old_locus_tag="BSU31050" /label="gbsB gene" downshifts complement(2835003) /Source="Nicolas_upshifts" /id="D1602" /incds=0 /nref=2 /ntot=70 /MaxReadThrough="2.9443" /MaxDrop="3.26923" /score="18.315772" /energy="-13.6" /TU="NA" /idTUdmin="U2406" /TUdmin="-660" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2835959..2835978) /Source="Nicolas_upshift_promotors" /id="U2407" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.66033966033966" /psig="0.983016983016983" /xcortree=2046 /SigmaFactorBS="aaagccggtgttgctgatcccgtaatcgaatCACTTAAAgaa gcaggcattgaAGTGGTACTCTTTAATAAAGttgagccaaacccgcctgtccgtctgg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2835971) /Source="Nicolas_upshifts" /id="U2407" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.66033966033966" /psig="0.983016983016983" /xcortree=2046 /SigmaFactorBS="aaagccggtgttgctgatcccgtaatcgaatCACTTAAAgaa gcaggcattgaAGTGGTACTCTTTAATAAAGttgagccaaacccgcctgtccgtctgg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2835993..2836000) /Source="Nicolas_upshift_promotors" /id="U2407" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.66033966033966" /psig="0.983016983016983" /xcortree=2046 /SigmaFactorBS="aaagccggtgttgctgatcccgtaatcgaatCACTTAAAgaa gcaggcattgaAGTGGTACTCTTTAATAAAGttgagccaaacccgcctgtccgtctgg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2836207..2837679) /gene="gbsA" /locus_tag="BSU_31060" /old_locus_tag="BSU31060" /EC_number="1.2.1.8" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8752328, 9297465, 22408163" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8752328, 9297465, 22408163; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycine betaine aldehyde dehydrogenase, NAD+-dependent" /protein_id="NP_390984.1" /db_xref="EnsemblGenomes-Gn:BSU31060" /db_xref="EnsemblGenomes-Tr:CAB15084" /db_xref="GOA:P71016" /db_xref="InterPro:IPR011264" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016160" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="SubtiList:BG11940" /db_xref="UniProtKB/Swiss-Prot:P71016" /translation="MSQTLFIDGEWISAEKEQIRSIINPFNQEEIATVSEGGREDAIK AIAAARRAFDKGEWSSLSGLERGKIVLKIAELIRRDLEELAELESLDTGKTLEESKAD MDDIANVFQYYAGLADKDGGEIISSPIPDSESKIIREPIGVCGQITPWNYPLLQASWK IAPALAAGNTIVMKPSEITPLTTIKVFKLMEEAGVPKGVANLVLGPGATVGDELAVNK DVDLISFTGGIETGKKIMRAASGNVKKIALELGGKNPNIVFKDADLEVAVDQALNAVF FHAGQVCSAGSRLLVEDAIHDQFLAELVKRAKRIKLGNGFHAETESGPLISAEHRAKV EKYVEIGIEEGAKLETGGKRPEDPELQNGFFYEPTIFSNCNSDMRIVQEEVFGPVLTV ETFSSEEEVIELANDTIYGLAGAVWSKDIEKCERVAARLRMGTVWINDFHPYFAQAPW GGYKQSGFGRELGKIGLEEYTEVKHVYRNTKPAAVNWFNS*" /label="gbsA CDS" gene complement(2836207..2837679) /gene="gbsA" /locus_tag="BSU_31060" /old_locus_tag="BSU31060" /label="gbsA gene" promotor_-10 complement(2837730..2837749) /Source="Nicolas_upshift_promotors" /id="U2408" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.8001998001998" /psig="0.999000999001" /xcortree=3079 /SigmaFactorBS="aaagaaaaatcaaaatgggaCTTTGACAgtttaaaaaccata TGTTAGATTAAGGTTGTTAAaaacattaaatttttatttaacaaactttatttacgtc a" /listShort="gbsA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2837731) /Source="Nicolas_upshifts" /id="U2408" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.8001998001998" /psig="0.999000999001" /xcortree=3079 /SigmaFactorBS="aaagaaaaatcaaaatgggaCTTTGACAgtttaaaaaccata TGTTAGATTAAGGTTGTTAAaaacattaaatttttatttaacaaactttatttacgtc a" /listShort="gbsA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2837764..2837771) /Source="Nicolas_upshift_promotors" /id="U2408" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.8001998001998" /psig="0.999000999001" /xcortree=3079 /SigmaFactorBS="aaagaaaaatcaaaatgggaCTTTGACAgtttaaaaaccata TGTTAGATTAAGGTTGTTAAaaacattaaatttttatttaacaaactttatttacgtc a" /listShort="gbsA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2837791..2837797 /Source="Nicolas_upshift_promotors" /id="U2409" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.318681318681319" /psig="0.988011988011988" /xcortree=2369 /SigmaFactorBS="tcaaagtcccattttgatttttcttTTTGACTtttcctcatg tttCGTTAAGATAAAGAACATAAagaaataacttaacgaatttaattttctaaaggaa a" /listShort="yuaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2837811..2837830 /Source="Nicolas_upshift_promotors" /id="U2409" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.318681318681319" /psig="0.988011988011988" /xcortree=2369 /SigmaFactorBS="tcaaagtcccattttgatttttcttTTTGACTtttcctcatg tttCGTTAAGATAAAGAACATAAagaaataacttaacgaatttaattttctaaaggaa a" /listShort="yuaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2837826 /Source="Nicolas_upshifts" /id="U2409" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.318681318681319" /psig="0.988011988011988" /xcortree=2369 /SigmaFactorBS="tcaaagtcccattttgatttttcttTTTGACTtttcctcatg tttCGTTAAGATAAAGAACATAAagaaataacttaacgaatttaattttctaaaggaa a" /listShort="yuaC" /GFF_Attribute="listLong" /label="upshifts" CDS 2837878..2838420 /gene="gbsR" /locus_tag="BSU_31070" /old_locus_tag="BSU31070" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8752328, 22408163" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8752328, 22408163; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor for gbsAB" /protein_id="NP_390985.1" /db_xref="EnsemblGenomes-Gn:BSU31070" /db_xref="EnsemblGenomes-Tr:CAB15085" /db_xref="GOA:P71015" /db_xref="InterPro:IPR026282" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12342" /db_xref="UniProtKB/Swiss-Prot:P71015" /translation="MDENPEFAAIEQARDLVIDSIAETMDLYGITRSVGILYGTMYMR DEMTLDEMREELQMSKPSMSTGVKKLQDLNVVKKTFHRGIRKHTFVAEKDFFKFFTNF FPPKWEREVQVNVTAIEEAQADLQKVLCKEDLDEDIKNEALQLYDQLESSKAYYDWLK RLAESVQTGEIFKFIPVETK*" /label="gbsR CDS" gene 2837878..2838420 /gene="gbsR" /locus_tag="BSU_31070" /old_locus_tag="BSU31070" /label="gbsR gene" downshifts 2838403 /Source="Nicolas_upshifts" /id="D1603" /incds=0 /nref=74 /ntot=220 /MaxReadThrough="1.70461" /MaxDrop="3.5918" /score="26.1509691" /energy="-9.9" /TU="NA" /idTUdmin="U2409" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 2838497..2838504 /Source="Nicolas_upshift_promotors" /id="U2410" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.657342657342657" /psig="0.999000999001" /xcortree=3240 /SigmaFactorBS="tgtaactactacaaatttgaaaaatacgggaaaaacacccCA TTTACTtccaaaatatttgaTGGTAATTTTATGTAGGTAAaatttgtatttggccttt c" /listShort="S1185, yuaB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2838517..2838617 /Source="Nicolas_S_feature" /locus_tag="new_3187402_3187502" /HighExp="BT, S0, BI, T-1.10H, T-1.40H, T1.0H, T-0.40H, T0.0H, S2, T-2.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1185" upshifts 2838517 /Source="Nicolas_upshifts" /id="U2410" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.657342657342657" /psig="0.999000999001" /xcortree=3240 /SigmaFactorBS="tgtaactactacaaatttgaaaaatacgggaaaaacacccCA TTTACTtccaaaatatttgaTGGTAATTTTATGTAGGTAAaatttgtatttggccttt c" /listShort="S1185, yuaB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2838519..2838538 /Source="Nicolas_upshift_promotors" /id="U2410" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.657342657342657" /psig="0.999000999001" /xcortree=3240 /SigmaFactorBS="tgtaactactacaaatttgaaaaatacgggaaaaacacccCA TTTACTtccaaaatatttgaTGGTAATTTTATGTAGGTAAaatttgtatttggccttt c" /listShort="S1185, yuaB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2838618..2839163 /gene="bslA" /locus_tag="BSU_31080" /old_locus_tag="BSU31080" /function="15.3: Cell adhesion" /experiment="publication(s) with functional evidences, PMID:21097620, 21742882, 22571672, 23904481, 28698374, 28701036, 28751732" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21097620, 21742882, 22571672, 23904481, 28698374, 28701036, 28751732; Product type s: structure" /codon_start=1 /transl_table=11 /product="biofilm hydrophobic layer component" /protein_id="NP_390986.1" /db_xref="EnsemblGenomes-Gn:BSU31080" /db_xref="EnsemblGenomes-Tr:CAB15086" /db_xref="GOA:P71014" /db_xref="InterPro:IPR034650" /db_xref="PDB:4BHU" /db_xref="SubtiList:BG12341" /db_xref="UniProtKB/Swiss-Prot:P71014" /translation="MKRKLLSSLAISALSLGLLVSAPTASFAAESTSTKAHTESTMRT QSTASLFATITGASKTEWSFSDIELTYRPNTLLSLGVMEFTLPSGFTANTKDTLNGNA LRTTQILNNGKTVRVPLALDLLGAGEFKLKLNNKTLPAAGTYTFRAENKSLSIGNKFY AEASIDVAKRSTPPTQPCGCN*" /label="bslA CDS" gene 2838618..2839163 /gene="bslA" /locus_tag="BSU_31080" /old_locus_tag="BSU31080" /label="bslA gene" downshifts 2839150 /Source="Nicolas_upshifts" /id="D1604" /incds=0 /nref=109 /ntot=219 /MaxReadThrough="0.85027" /MaxDrop="6.00835" /score="20.8976757" /energy="-10.2" /TU="NA" /idTUdmin="U2410" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 2839255..2839262 /Source="Nicolas_upshift_promotors" /id="U2411" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.796203796203796" /psig="0.997002997002997" /xcortree=2704 /SigmaFactorBS="ccccgttatcttttttctggtttaaaatttaaATTGACAAac actagaaacagGAGTAAATTCTTGAGTGTTCaatttcatacagtctcttttaccgctt a" /listShort="NA, ktrA, ktrB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2839276..2839295 /Source="Nicolas_upshift_promotors" /id="U2411" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.796203796203796" /psig="0.997002997002997" /xcortree=2704 /SigmaFactorBS="ccccgttatcttttttctggtttaaaatttaaATTGACAAac actagaaacagGAGTAAATTCTTGAGTGTTCaatttcatacagtctcttttaccgctt a" /listShort="NA, ktrA, ktrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2839283 /Source="Nicolas_upshifts" /id="U2411" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.796203796203796" /psig="0.997002997002997" /xcortree=2704 /SigmaFactorBS="ccccgttatcttttttctggtttaaaatttaaATTGACAAac actagaaacagGAGTAAATTCTTGAGTGTTCaatttcatacagtctcttttaccgctt a" /listShort="NA, ktrA, ktrB" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 2839288..2839456 /gene="swdA" /locus_tag="BSU_misc_RNA_52" /product="cyclic-di-AMP-sensing riboswitch" /experiment="publication(s) with functional evidences, PMID:20511502, 23086297, 24141192, 25086507, 25086509, 26789423, 28420751" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20511502, 23086297, 24141192, 25086507, 25086509, 26789423, 28420751; Product type n: RNA" /label="swdA RNA" gene 2839288..2839456 /gene="swdA" /locus_tag="BSU_misc_RNA_52" /label="swdA gene" downshifts 2839437 /Source="Nicolas_upshifts" /id="D1605" /incds=0 /nref=16 /ntot=104 /MaxReadThrough="6.04086" /MaxDrop="4.75274" /score="3.29445061" /energy="-6.1" /TU="U2411" /idTUdmin="U2410" /TUdmin=286 /isTUend="FALSE" /label="downshifts" CDS 2839529..2840197 /gene="ktrA" /locus_tag="BSU_31090" /old_locus_tag="BSU31090" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12562800, 15096624, 23598340, 23671116, 25957408, 26771197" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12562800, 15096624, 23598340, 23671116, 25957408, 26771197; Product type t : transporter" /codon_start=1 /transl_table=11 /product="potassium uptake protein" /protein_id="NP_390987.1" /db_xref="EnsemblGenomes-Gn:BSU31090" /db_xref="EnsemblGenomes-Tr:CAB15087" /db_xref="GOA:O32080" /db_xref="InterPro:IPR003148" /db_xref="InterPro:IPR006037" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR036721" /db_xref="PDB:1LSU" /db_xref="PDB:2HMS" /db_xref="PDB:2HMT" /db_xref="PDB:2HMU" /db_xref="PDB:2HMV" /db_xref="PDB:2HMW" /db_xref="PDB:4J7C" /db_xref="PDB:4J90" /db_xref="PDB:4J91" /db_xref="PDB:5BUT" /db_xref="SubtiList:BG13943" /db_xref="UniProtKB/Swiss-Prot:O32080" /translation="MGRIKNKQFAVIGLGRFGGSICKELHRMGHEVLAVDINEEKVNA YASYATHAVIANATEENELLSLGIRNFEYVIVAIGANIQASTLTTLLLKELDIPNIWV KAQNYYHHKVLEKIGADRIIHPEKDMGVKIAQSLSDENVLNYIDLSDEYSIVELLATR KLDSKSIIDLNVRAKYGCTILAIKHHGDICLSPAPEDIIREQDCLVIMGHKKDIKRFE NEGM*" /label="ktrA CDS" gene 2839529..2840197 /gene="ktrA" /locus_tag="BSU_31090" /old_locus_tag="BSU31090" /label="ktrA gene" CDS 2840204..2841541 /gene="ktrB" /locus_tag="BSU_31100" /old_locus_tag="BSU31100" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12562800, 15096624, 15849754, 16850406, 17932047, 23598340, 26771197, 28783096, 28825218" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12562800, 15096624, 15849754, 16850406, 17932047, 23598340, 26771197, 28783096, 28825218; Product type t: transporter" /codon_start=1 /transl_table=11 /product="potassium transporter ATPase" /protein_id="NP_390988.1" /db_xref="EnsemblGenomes-Gn:BSU31100" /db_xref="EnsemblGenomes-Tr:CAB15088" /db_xref="GOA:O32081" /db_xref="InterPro:IPR003445" /db_xref="InterPro:IPR004772" /db_xref="PDB:4J7C" /db_xref="PDB:5BUT" /db_xref="SubtiList:BG13956" /db_xref="UniProtKB/Swiss-Prot:O32081" /translation="MTLQKDKVIKWVRFTPPQVLAIGFFLTIIIGAVLLMLPISTTKP LSWIDALFTAASATTVTGLAVVDTGTQFTVFGQTVIMGLIQIGGLGFMTFAVLIVMIL GKKIGLKERMLVQEALNQPTIGGVIGLVKVLFLFSISIELIAALILSIRLVPQYGWSS GLFASLFHAISAFNNAGFSLWPDNLMSYVGDPTVNLVITFLFITGGIGFTVLFDVMKN RRFKTFSLHTKLMLTGTLMLNAIAMLTVFILEYSNPGTLGHLHIVDKLWASYFQAVTP RTAGFNSLDFGSMREGTIVFTLLLMFIGAGSASTASGIKLTTFIVILTSVIAYLRGKK ETVIFRRSIKYPIIIKALAVSVTSLFIVFLGIFALTITEQAPFLQIVFETFSAFGTVG LTMGLTPELTTAGKCIIIVIMFIGRIGPLTFVFSFAKTEQSNIRYPDGEVFTG*" /label="ktrB CDS" gene 2840204..2841541 /gene="ktrB" /locus_tag="BSU_31100" /old_locus_tag="BSU31100" /label="ktrB gene" downshifts 2841527 /Source="Nicolas_upshifts" /id="D1606" /incds=0 /nref=9 /ntot=98 /MaxReadThrough="0.86883" /MaxDrop="3.37604" /score="25.8974852" /energy="-11.9" /TU="NA" /idTUdmin="U2411" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2841577..2841840) /gene="yubF" /locus_tag="BSU_31110" /old_locus_tag="BSU31110" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_390989.1" /db_xref="EnsemblGenomes-Gn:BSU31110" /db_xref="EnsemblGenomes-Tr:CAB15089" /db_xref="GOA:O32082" /db_xref="InterPro:IPR008024" /db_xref="SubtiList:BG13955" /db_xref="UniProtKB/Swiss-Prot:O32082" /translation="MQKYRRRNTVAFTVLAYFTFFAGVFLFSIGLYNADNLELNEKGY YIAVMILVAVGAILTQKVTRDNAEDNEIIAEQEKRQNQSHIES*" /label="yubF CDS" gene complement(2841577..2841840) /gene="yubF" /locus_tag="BSU_31110" /old_locus_tag="BSU31110" /label="yubF gene" downshifts complement(2841595) /Source="Nicolas_upshifts" /id="D1607" /incds=0 /nref=237 /ntot=309 /MaxReadThrough="2.4577" /MaxDrop="7.13564" /score="30.2020977" /energy="-11.9" /TU="NA" /idTUdmin="U2412" /TUdmin="-14" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2841880..2841899) /Source="Nicolas_upshift_promotors" /id="U2412" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.543456543456543" /psig="0.994005994005994" /xcortree=2705 /SigmaFactorBS="tttactggtatttttaattctttGTTCCATTccggggaattt gAGGTATAATATTCCACGGAAgttatcactttttaactatgctttcgggagggaacaa a" /listShort="yubF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2841882) /Source="Nicolas_upshifts" /id="U2412" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.543456543456543" /psig="0.994005994005994" /xcortree=2705 /SigmaFactorBS="tttactggtatttttaattctttGTTCCATTccggggaattt gAGGTATAATATTCCACGGAAgttatcactttttaactatgctttcgggagggaacaa a" /listShort="yubF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2841912..2841919) /Source="Nicolas_upshift_promotors" /id="U2412" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.543456543456543" /psig="0.994005994005994" /xcortree=2705 /SigmaFactorBS="tttactggtatttttaattctttGTTCCATTccggggaattt gAGGTATAATATTCCACGGAAgttatcactttttaactatgctttcgggagggaacaa a" /listShort="yubF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2841949..2842797) /gene="lytG" /locus_tag="BSU_31120" /old_locus_tag="BSU31120" /EC_number="3.2.1.-" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12525152, 16855244, 28448118, 28811162" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12525152, 16855244, 28448118, 28811162; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exoglucosaminidase" /protein_id="NP_390990.1" /db_xref="EnsemblGenomes-Gn:BSU31120" /db_xref="EnsemblGenomes-Tr:CAB15090" /db_xref="GOA:O32083" /db_xref="InterPro:IPR002901" /db_xref="InterPro:IPR025987" /db_xref="SubtiList:BG13954" /db_xref="UniProtKB/Swiss-Prot:O32083" /translation="MARKKLKKRKLLISLFFLVSIPLALFVLATTLSKPIEISKETEE IDEQQVFIDSLSGHAQILYEKYHVLPSITIAQAILESDWGNSELAAKANNLFGVKGNY KGHHVTMETDEVEKGKRKTIRAKFRKYSTFFESMDDHAQLFVRGTSWNKKKYKPVLEA GNYKEAATALQTSGYATDPDYADKISAIVEKYDLDEYDEVNPSLKSVDLNASIKDSAV QDVWSKPSTDDRSIRLTSAQSYVGKDIKVVSKKQKGQSVWYQFQINDKLIGWIDDSAV EIKEAT*" /label="lytG CDS" gene complement(2841949..2842797) /gene="lytG" /locus_tag="BSU_31120" /old_locus_tag="BSU31120" /label="lytG gene" promotor_-10 complement(2842842..2842861) /Source="Nicolas_upshift_promotors" /id="U2413" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.40959040959041" /psig="0.994005994005994" /xcortree=2525 /SigmaFactorBS="gcaatcttttcccaactttatccctaaagAATTGAAAaatat tagaagtgcAAGTAAAATTCTAAAAGGTAgattcttttacattcgtaatcttttaatt c" /listShort="lytG, yubF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2842852) /Source="Nicolas_upshifts" /id="U2413" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.40959040959041" /psig="0.994005994005994" /xcortree=2525 /SigmaFactorBS="gcaatcttttcccaactttatccctaaagAATTGAAAaatat tagaagtgcAAGTAAAATTCTAAAAGGTAgattcttttacattcgtaatcttttaatt c" /listShort="lytG, yubF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2842876..2842883) /Source="Nicolas_upshift_promotors" /id="U2413" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.40959040959041" /psig="0.994005994005994" /xcortree=2525 /SigmaFactorBS="gcaatcttttcccaactttatccctaaagAATTGAAAaatat tagaagtgcAAGTAAAATTCTAAAAGGTAgattcttttacattcgtaatcttttaatt c" /listShort="lytG, yubF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2842958..2844493) /gene="yubD" /locus_tag="BSU_31130" /old_locus_tag="BSU31130" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735, 28248504; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_390991.1" /db_xref="EnsemblGenomes-Gn:BSU31130" /db_xref="EnsemblGenomes-Tr:CAB15091" /db_xref="GOA:O32084" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG13953" /db_xref="UniProtKB/Swiss-Prot:O32084" /translation="MKTKHYWVISLLAVLAVGPGLMSNTALSSVQGLVQKTVGTSVFT SVNPILIGNMAFALLVPAGPLLRKKFGARPVYLASLPVFILGSLLIACSGDIALMAAG RFLQGAATGVMLMIMIPMLVLSFPIERRNYALLVLIGGFYGSVIIGTILGTIATSCGH WRWLFFIFGTLSLIGVAVSYFFLHDEHHGAADQEQPLDRAGILLSVFLAAASAVSFIF LQKWGLSSGYVWIGFGVTLCLLIGLLIVEYKVKNPFISIKLMLLPKPVLGLLIIAAGT ITVAVSLSAFQGLLRQMYDISQEHLILLSLTLLIGVAIAAILSALLYDKVGPGMLGII GGLILVFVNFQWLHIQDRSSLYMFAALFIMLAAGTGLTVAAGLMGAAMGGPLPDLVKR MTAVQFLRLFVYMGVPILIGFFTKKDAARQSGSVQDSMMTAYHDLFFISFILSVLLVC LSFCMNATGMGHKLAHKPHDKAKTAPEKPAVSAQGLSKATVKSYKVINDTEYRNALRN LQK*" /label="yubD CDS" gene complement(2842958..2844493) /gene="yubD" /locus_tag="BSU_31130" /old_locus_tag="BSU31130" /label="yubD gene" downshifts complement(2842967) /Source="Nicolas_upshifts" /id="D1608" /incds=0 /nref=45 /ntot=159 /MaxReadThrough="1.39941" /MaxDrop="4.26166" /score="-3.3162201" /energy="-5.7" /TU="NA" /idTUdmin="U2415" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_no_box 2844151..2844251 /Source="Nicolas_upshift_promotors" /id="U2414" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.407592407592408" /psig="0.127872127872128" /xcortree=1469 /SigmaFactorBS="tcagcatgacgcctgttgccgccccttgtaaaaagcgccctg ccgccatcaatgcaatatcgcctgaacatgcgatgagcagtgagcctagtataaagac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 2844211 /Source="Nicolas_upshifts" /id="U2414" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.407592407592408" /psig="0.127872127872128" /xcortree=1469 /SigmaFactorBS="tcagcatgacgcctgttgccgccccttgtaaaaagcgccctg ccgccatcaatgcaatatcgcctgaacatgcgatgagcagtgagcctagtataaagac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2844277 /Source="Nicolas_upshifts" /id="D1609" /incds=1 /nref=1 /ntot=3 /MaxReadThrough="0.0870599999999992" /MaxDrop="3.19459" /score="-1.6836786" /energy="-10.4" /TU="NA" /idTUdmin="U2416" /TUdmin="-1496" /isTUend="FALSE" /label="downshifts" S_feature complement(2844494..2844661) /Source="Nicolas_S_feature" /locus_tag="new_3193379_3193546_c" /HighExp="Cold, S8, G180, UNK1, C30, G135, S7, Lbexp, MG 25, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.34877900000000001" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1186" promotor_-10 complement(2844650..2844669) /Source="Nicolas_upshift_promotors" /id="U2415" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.642357642357642" /psig=1 /xcortree=2415 /SigmaFactorBS="agctttctatgttgtgcttgaaatttactcCATTGACAaaac acaatcgattTGAAATAATATTTGATTATAtgctcattcattcacataattataataa a" /listShort="S1186, yubD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2844661) /Source="Nicolas_upshifts" /id="U2415" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.642357642357642" /psig=1 /xcortree=2415 /SigmaFactorBS="agctttctatgttgtgcttgaaatttactcCATTGACAaaac acaatcgattTGAAATAATATTTGATTATAtgctcattcattcacataattataataa a" /listShort="S1186, yubD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2844663..2845540) /Source="Nicolas_S_feature" /locus_tag="new_3193548_3194425_c" /HighExp="G180, Cold, C30, G135, Paraq, Oxctl, S8, G150, H2O2, Heat" /AntisenseName="cdoA" /AntisenseCor="-2.3104546834536201E-2" /AntisenseRegPval="-0.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1187" promotor_-35 complement(2844684..2844691) /Source="Nicolas_upshift_promotors" /id="U2415" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.642357642357642" /psig=1 /xcortree=2415 /SigmaFactorBS="agctttctatgttgtgcttgaaatttactcCATTGACAaaac acaatcgattTGAAATAATATTTGATTATAtgctcattcattcacataattataataa a" /listShort="S1186, yubD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2844903..2844912 /Source="Nicolas_upshift_promotors" /id="U2416" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1385 /SigmaFactorBS="ttttacccccacatttttttgtgttcactgggcgtttGCCGC CTCTAaattgtatatgggTAAATACCATGAATTAACCTatgaaataccaatgtaaggg a" /listShort="cdoA, S1188" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2844926..2844945 /Source="Nicolas_upshift_promotors" /id="U2416" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1385 /SigmaFactorBS="ttttacccccacatttttttgtgttcactgggcgtttGCCGC CTCTAaattgtatatgggTAAATACCATGAATTAACCTatgaaataccaatgtaaggg a" /listShort="cdoA, S1188" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2844926 /Source="Nicolas_upshifts" /id="U2416" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1385 /SigmaFactorBS="ttttacccccacatttttttgtgttcactgggcgtttGCCGC CTCTAaattgtatatgggTAAATACCATGAATTAACCTatgaaataccaatgtaaggg a" /listShort="cdoA, S1188" /GFF_Attribute="listLong" /label="upshifts" CDS 2844978..2845463 /gene="cdoA" /locus_tag="BSU_31140" /old_locus_tag="BSU31140" /EC_number="1.13.11.20" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10939241, 15699190, 16855246, 25307852, 26590284" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 15699190, 16855246, 25307852, 26590284; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cysteine dioxygenase" /protein_id="NP_390992.1" /db_xref="EnsemblGenomes-Gn:BSU31140" /db_xref="EnsemblGenomes-Tr:CAB15092" /db_xref="GOA:O32085" /db_xref="InterPro:IPR010300" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014710" /db_xref="PDB:3EQE" /db_xref="PDB:4QM8" /db_xref="PDB:4QM9" /db_xref="SubtiList:BG13952" /db_xref="UniProtKB/Swiss-Prot:O32085" /translation="MELYECIQDIFGGLKNPSVKDLATSLKQIPNAAKLSQPYIKEPD QYAYGRNAIYRNNELEIIVINIPPNKETTVHDHGQSIGCAMVLEGKLLNSIYRSTGEH AELSNSYFVHEGECLISTKGLIHKMSNPTSERMVSLHVYSPPLEDMTVFEEQKEVLEN S*" /label="cdoA CDS" gene 2844978..2845463 /gene="cdoA" /locus_tag="BSU_31140" /old_locus_tag="BSU31140" /label="cdoA gene" S_feature 2845464..2845750 /Source="Nicolas_S_feature" /locus_tag="new_3194349_3194635" /HighExp="S6, S8, S7, BT, S5, G/S, C30, Pyr, C90, Glucon" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.53171800000000002" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1188" tRNA complement(2845570..2845642) /gene="trnSL-Ala1" /locus_tag="BSU_tRNA_86" /product="tRNA-Ala" /inference="profile:tRNAscan:1.23" /note="transfer RNA-Ala (GGC); Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /label="trnSL-Ala1 tRNA" gene complement(2845570..2845642) /gene="trnSL-Ala1" /locus_tag="BSU_tRNA_86" /label="trnSL-Ala1 gene" downshifts complement(2845585) /Source="Nicolas_upshifts" /id="D1610" /incds=0 /nref=37 /ntot=180 /MaxReadThrough="3.88031" /MaxDrop="4.38957" /score="19.7542652" /energy="-6.2" /TU="U2417" /idTUdmin="U2419" /TUdmin=154 /isTUend="FALSE" /label="downshifts" downshifts complement(2845629) /Source="Nicolas_upshifts" /id="D1611" /incds=0 /nref=1 /ntot=11 /MaxReadThrough="5.34085" /MaxDrop="4.19639" /score="19.7542652" /energy="-6.2" /TU="U2417" /idTUdmin="U2419" /TUdmin=110 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2845653..2845672) /Source="Nicolas_upshift_promotors" /id="U2417" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=1471 /SigmaFactorBS="cttttccgagccttattttttctgtcaattcaagaggaaaca gCTTGtttttcaaaataaaATCATCTATAATAAACATGAcgttacatacggggccata g" /listShort="trnSL-Ala1, S1187, S1186, yubD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2845673) /Source="Nicolas_upshifts" /id="U2417" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=1471 /SigmaFactorBS="cttttccgagccttattttttctgtcaattcaagaggaaaca gCTTGtttttcaaaataaaATCATCTATAATAAACATGAcgttacatacggggccata g" /listShort="trnSL-Ala1, S1187, S1186, yubD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2845687..2845690) /Source="Nicolas_upshift_promotors" /id="U2417" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=1471 /SigmaFactorBS="cttttccgagccttattttttctgtcaattcaagaggaaaca gCTTGtttttcaaaataaaATCATCTATAATAAACATGAcgttacatacggggccata g" /listShort="trnSL-Ala1, S1187, S1186, yubD" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2845707 /Source="Nicolas_upshifts" /id="D1612" /incds=0 /nref=2 /ntot=13 /MaxReadThrough="3.04964" /MaxDrop="3.22361" /score="-1.6836786" /energy="-10.4" /TU="U2416" /idTUdmin="U2416" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" CDS complement(2845750..2846580) /gene="uppP" /locus_tag="BSU_31150" /old_locus_tag="BSU31150" /EC_number="3.6.1.27" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15138271, 15849754, 16850406, 27528508, 27578312" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15138271, 15849754, 16850406, 27528508, 27578312; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="undecaprenyl-pyrophosphate phosphatase" /protein_id="NP_390993.1" /db_xref="EnsemblGenomes-Gn:BSU31150" /db_xref="EnsemblGenomes-Tr:CAB15093" /db_xref="GOA:P94507" /db_xref="InterPro:IPR003824" /db_xref="SubtiList:BG13951" /db_xref="UniProtKB/Swiss-Prot:P94507" /translation="MTLWELFVAAILGIVEGLTEYAPVSSTGHMIIVDDIWLKSSNLM SEEAANSFKVVIQLGSILAVAIVFKDRILNLLGLKKNITSDQEQGHKLSIAQIAVGLV PAAVLGFLFEDYIDEYLFSVKTVAIGLIAGAILMLFADWVNKRKTATDTLDRISYKQA IAVGLFQCLSLWPGFSRSGSTISGGVILGLNHRAAADFTFIMAMPIMMGASFLSLVKH WDSLSSDLMPFFIVGFICAFVVALFVVRFFLRLINKIKLVPFAIYRIILGVILLLIMM *" /label="uppP CDS" gene complement(2845750..2846580) /gene="uppP" /locus_tag="BSU_31150" /old_locus_tag="BSU31150" /label="uppP gene" downshifts complement(2845761) /Source="Nicolas_upshifts" /id="D1613" /incds=0 /nref=60 /ntot=208 /MaxReadThrough="3.0552" /MaxDrop="5.61932" /score="-4.25033697" /energy="-6.7" /TU="U2419" /idTUdmin="U2419" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" S_feature complement(2846581..2846672) /Source="Nicolas_S_feature" /locus_tag="new_3195466_3195557_c" /HighExp="dia15, H2O2, Salt, Etha, dia5, LBGtran, M0t90, Lbstat, Mt0, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1189" CDS complement(2846673..2847839) /gene="yubA" /locus_tag="BSU_31160" /old_locus_tag="BSU31160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16385049, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_390994.1" /db_xref="EnsemblGenomes-Gn:BSU31160" /db_xref="EnsemblGenomes-Tr:CAB15094" /db_xref="GOA:O32086" /db_xref="InterPro:IPR002549" /db_xref="SubtiList:BG13950" /db_xref="UniProtKB/Swiss-Prot:O32086" /translation="METLQTWSGRFKRFFLDNKFVLFLLVLLLIGLNILVFTKTSFIF TPIIVLLKTISLPIILTGIVFYLLNPVVDFLERRRIRRIYSILLLYLLVIGLITITIV SIIPFLKEQIMSLIDNIPRYVDVVENQTKQLIGSNFVNQAQQTMNINISDLATKVSDQ AATIVNSTFTGVGNFIGALTEIIISIVTVPFILFYLLKDGRKLPVYILKFVPTRLKEQ TYTVLSEMNHRLSSYIRGQIIVSFCIGFLLFIGYLIIGLDYASLLAVIAACTSIVPYL GPTIAITPAIIIAIVTSPLMLLKLVIVWTIVQLIEGKLISPQIMGKNLHIHPITIIFL LLTAGKLFGVVGIILAIPGYAVAKVITTHLFDWFKMQSHLYDEEKNENTPGHKV*" /label="yubA CDS" gene complement(2846673..2847839) /gene="yubA" /locus_tag="BSU_31160" /old_locus_tag="BSU31160" /label="yubA gene" promotor_-35 2847835..2847839 /Source="Nicolas_upshift_promotors" /id="U2418" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.926073926073926" /psig="0.04995004995005" /xcortree=303 /SigmaFactorBS="gcttgaatctgccgctccatgtttgcaacgtcTCCACtatcg ttCCTCCGTCATACATAgtttaattaaattgtacactatcgtccctataatgaaaaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2847847..2847861 /Source="Nicolas_upshift_promotors" /id="U2418" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.926073926073926" /psig="0.04995004995005" /xcortree=303 /SigmaFactorBS="gcttgaatctgccgctccatgtttgcaacgtcTCCACtatcg ttCCTCCGTCATACATAgtttaattaaattgtacactatcgtccctataatgaaaaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2847863..2847882) /Source="Nicolas_upshift_promotors" /id="U2419" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.706293706293706" /psig=1 /xcortree=1913 /SigmaFactorBS="gttaaaaccgagaaagcttttccagcaattaacggttttTAT TTTTCattatagggacgaTAGTGTACAATTTAATTAAActatgtatgacggaggaacg a" /listShort="yubA, S1189, uppP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2847863 /Source="Nicolas_upshifts" /id="U2418" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.926073926073926" /psig="0.04995004995005" /xcortree=303 /SigmaFactorBS="gcttgaatctgccgctccatgtttgcaacgtcTCCACtatcg ttCCTCCGTCATACATAgtttaattaaattgtacactatcgtccctataatgaaaaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(2847882) /Source="Nicolas_upshifts" /id="U2419" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.706293706293706" /psig=1 /xcortree=1913 /SigmaFactorBS="gttaaaaccgagaaagcttttccagcaattaacggttttTAT TTTTCattatagggacgaTAGTGTACAATTTAATTAAActatgtatgacggaggaacg a" /listShort="yubA, S1189, uppP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2847896..2847903) /Source="Nicolas_upshift_promotors" /id="U2419" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.706293706293706" /psig=1 /xcortree=1913 /SigmaFactorBS="gttaaaaccgagaaagcttttccagcaattaacggttttTAT TTTTCattatagggacgaTAGTGTACAATTTAATTAAActatgtatgacggaggaacg a" /listShort="yubA, S1189, uppP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2847961..2847968 /Source="Nicolas_upshift_promotors" /id="U2420" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.79020979020979" /psig=1 /xcortree=2346 /SigmaFactorBS="attgctggaaaagctttctcggttttaacattctatttatat ctatcATGTGATTttgttcttttTAAGCTATAATTTAGCTATAtcatgcaaaaggagc g" /listShort="yulF" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2847974 /Source="Nicolas_upshifts" /id="U2420" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.79020979020979" /psig=1 /xcortree=2346 /SigmaFactorBS="attgctggaaaagctttctcggttttaacattctatttatat ctatcATGTGATTttgttcttttTAAGCTATAATTTAGCTATAtcatgcaaaaggagc g" /listShort="yulF" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2847979..2847998 /Source="Nicolas_upshift_promotors" /id="U2420" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.79020979020979" /psig=1 /xcortree=2346 /SigmaFactorBS="attgctggaaaagctttctcggttttaacattctatttatat ctatcATGTGATTttgttcttttTAAGCTATAATTTAGCTATAtcatgcaaaaggagc g" /listShort="yulF" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2848021..2849007 /gene="iolU" /locus_tag="BSU_31170" /old_locus_tag="BSU31170" /EC_number="1.1.1.371" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:12450853, 28043209" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12450853, 28043209; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="scyllo-inositol dehydrogenase (NADP+-dependent);biofilm formation" /protein_id="NP_390995.1" /db_xref="EnsemblGenomes-Gn:BSU31170" /db_xref="EnsemblGenomes-Tr:CAB15095" /db_xref="GOA:O05265" /db_xref="InterPro:IPR000683" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12388" /db_xref="UniProtKB/Swiss-Prot:O05265" /translation="MIRFAIIGTNWITDRFLESAADIEDFQLTAVYSRSAERAGEFAA KHNAAHAFSDLQEMAASDCFDAVYIASPNALHKEQAVLFMNHGKHVLCEKPFASNTKE TEEMISAAKANGVVLMEAMKTTFLPNFKELKKHLHKIGTVRRFTASYCQYSSRYDAFR SGTVLNAFQPELSNGSLMDIGVYCIYPAVVLFGAPKDVKANGYALSSGVDGEGTVILS YDGFEAVLMHSKISTSYAPAEIQGEDGTIVIDTIHRPERVEIRYRDGRLENIAIPDPK PAMFYEAEEFVTLIKENKLESEENTFERSLTTAKIMEEARKQMGIVYPADQA*" /label="iolU CDS" gene 2848021..2849007 /gene="iolU" /locus_tag="BSU_31170" /old_locus_tag="BSU31170" /label="iolU gene" downshifts 2848978 /Source="Nicolas_upshifts" /id="D1614" /incds=0 /nref=30 /ntot=279 /MaxReadThrough="1.83109" /MaxDrop="4.96985" /score="21.8997198" /energy="-15.1" /TU="NA" /idTUdmin="U2420" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" CDS complement(2849048..2850322) /gene="rhaA" /locus_tag="BSU_31180" /old_locus_tag="BSU31180" /EC_number="5.3.1.14" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10960106, 26712933" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10960106, 26712933; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-rhamnose isomerase" /protein_id="NP_390996.1" /db_xref="EnsemblGenomes-Gn:BSU31180" /db_xref="EnsemblGenomes-Tr:CAB15096" /db_xref="GOA:O05264" /db_xref="InterPro:IPR009308" /db_xref="InterPro:IPR036237" /db_xref="SubtiList:BG12387" /db_xref="UniProtKB/Swiss-Prot:O05264" /translation="MTIKANYDSAKQAYEKWGIDVEEALRQLEQVPISIHCWQGDDIE GFEVNKGELSGGIDVTGNYPGKAQTPEELRRDLEKALSLIPGKHRVNLHAIYAETNRE AVERDELKPQHFENWVKWAKNLGLGLDFNPTLFSHEKAADGLTLSHPDPDIREFWIRH CIACRRIGEYFGKELGTPCLTNIWIPDGYKDIPSDRLTPRKRLKESLDRIFSEEISEQ HNLDSIESKLFGLGSESYVVGSHEFYLAYALTNHKLCLLDTGHFHPTETVSNKISSML LYTDKLALHVSRPVRWDSDHVVVLDDELREIALEIVRNHALEKVAIGLDFFDASINRV AAWTIGTRNMIKALLYALLLPNGYLKQLQEEGRYTERLALMEEFKTYPFGAIWDSYCE QMGVPVKEAWLYDIKEYEQQVLLKRKASSPIV*" /label="rhaA CDS" gene complement(2849048..2850322) /gene="rhaA" /locus_tag="BSU_31180" /old_locus_tag="BSU31180" /label="rhaA gene" downshifts complement(2849061) /Source="Nicolas_upshifts" /id="D1615" /incds=0 /nref=3 /ntot=29 /MaxReadThrough="0.802" /MaxDrop="4.45322" /score="14.0829844" /energy="-12.6" /TU="NA" /idTUdmin="U2421" /TUdmin=242 /isTUend="FALSE" /label="downshifts" CDS complement(2850348..2850662) /gene="rhaM" /locus_tag="BSU_31190" /old_locus_tag="BSU31190" /EC_number="5.1.3.32" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15576793, 15876375, 26712933" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15576793, 15876375, 26712933; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-rhamnose mutarotase" /protein_id="NP_390997.1" /db_xref="EnsemblGenomes-Gn:BSU31190" /db_xref="EnsemblGenomes-Tr:CAB15097" /db_xref="GOA:O05263" /db_xref="InterPro:IPR008000" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR013448" /db_xref="SubtiList:BG12386" /db_xref="UniProtKB/Swiss-Prot:O05263" /translation="MKRKASIMFVHQDKYEEYKQRHDDIWPEMAEALKAHGAHHYSIF LDEETGRLFAYLEIEDEEKWRKMADTEVCQRWWKSMAPLMKTNSDFSPVAIDLKEVFY LD*" /label="rhaM CDS" gene complement(2850348..2850662) /gene="rhaM" /locus_tag="BSU_31190" /old_locus_tag="BSU31190" /label="rhaM gene" CDS complement(2850680..2852137) /gene="rhaB" /locus_tag="BSU_31200" /old_locus_tag="BSU31200" /EC_number="2.7.1.5" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16674975, 26712933" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16674975, 26712933; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="rhamnulokinase" /protein_id="NP_390998.1" /db_xref="EnsemblGenomes-Gn:BSU31200" /db_xref="EnsemblGenomes-Tr:CAB15098" /db_xref="GOA:O05262" /db_xref="InterPro:IPR000577" /db_xref="InterPro:IPR013449" /db_xref="InterPro:IPR018484" /db_xref="InterPro:IPR018485" /db_xref="SubtiList:BG12385" /db_xref="UniProtKB/Swiss-Prot:O05262" /translation="MIYTAIDVGASSGRIMVGELNEGKLDIQEIHRFANGFSQRDGHC LWDIDHLLKQILQGLQKVKTLGYEHCTVGIDTWAVDYVLLDEKGDRLREAISYRDRRT DHTIDKLEHTLSKAAIYQKTGIQFQPFNTIYQLFEEDRELLKKTDKIMMIPDYLGYCL TGKAVTEITNVSTTQLLNVSTGNLDPELLEAVSVLEQQFAPLTEPGCELGKLRNEWFP DYDLPACKVMTVATHDTASAVIAAPGVNDGWAYISSGTWSLIGVENKTPIITDLALEN NYTNERGANNTIRFLKNIIGMWVIQEVKQQLQADYSFQQLAEEAKKTEPFQQFINLND KRFLNPENMIKEIQHYCRQTRQKIPRTAGELACCIYSNLAIIYAIAIKELETITEKPI EQFHIIGGGARNDFLNQLTADMSGKAVYAGPIEATATGNLLMQMIAAKEVKDIKEARQ VVRNSFPIKVFTPKDIDRSTIIQSFQQTVLKALSK*" /label="rhaB CDS" gene complement(2850680..2852137) /gene="rhaB" /locus_tag="BSU_31200" /old_locus_tag="BSU31200" /label="rhaB gene" CDS complement(2852142..2852918) /gene="rhaR" /locus_tag="BSU_31210" /old_locus_tag="BSU31210" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11496004, 26712933" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11496004, 26712933; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of the rhamnose operon(RhaR / l-rhamnulose-1-phosphate)" /protein_id="NP_390999.1" /db_xref="EnsemblGenomes-Gn:BSU31210" /db_xref="EnsemblGenomes-Tr:CAB15099" /db_xref="GOA:O05261" /db_xref="InterPro:IPR001034" /db_xref="InterPro:IPR014036" /db_xref="InterPro:IPR018356" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12384" /db_xref="UniProtKB/Swiss-Prot:O05261" /translation="MLVAERQQKIVEIVNMRSSIRVSELSDIFSVTEETIRRDLEKLE KEHKLSRSHGGAVSIQQKESEIHFSEREITNVIEKKAIAHEAAKYVKSGDRIILDAST TAWYMAKILPDIELTVITNSMKAAIELSNKENISVISTGGILLEKSLSFAGPLAERSL ETYHVNKTFLSCKGFDVHNGMSDSNEWQALLKKRMIERSDQTILMADSSKWGNREFSH IASLQDVSRLITDSGLDPASVKALEDKKVKVTAVPLSKRG*" /label="rhaR CDS" gene complement(2852142..2852918) /gene="rhaR" /locus_tag="BSU_31210" /old_locus_tag="BSU31210" /label="rhaR gene" misc_feature complement(2852952..2852971) /Source="Nicolas_upshift_promotors" /id="U2421" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig="0.999000999001" /xcortree=3189 /SigmaFactorBS="acgggctgcatgatcacggtagacggcggcgtccctgctgct tttacgcgttagataTATGCTATGATAAAAATATAagacggactacgatatgaggaag g" /listShort="yulB, yulC, yulD, yulE" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2852968) /Source="Nicolas_upshifts" /id="U2421" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig="0.999000999001" /xcortree=3189 /SigmaFactorBS="acgggctgcatgatcacggtagacggcggcgtccctgctgct tttacgcgttagataTATGCTATGATAAAAATATAagacggactacgatatgaggaag g" /listShort="yulB, yulC, yulD, yulE" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2852975..2855044) /gene="rhaE" /locus_tag="BSU_31220" /old_locus_tag="BSU31220" /EC_number="1.1.1.-" /EC_number="4.1.2.19" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:24391637, 26712933" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 24391637, 26712933; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional rhamnulose-1-phosphate aldolase/alcohol dehydrogenase" /protein_id="NP_391000.1" /db_xref="EnsemblGenomes-Gn:BSU31220" /db_xref="EnsemblGenomes-Tr:CAB15100" /db_xref="GOA:P40747" /db_xref="InterPro:IPR001303" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR013454" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR036409" /db_xref="SubtiList:BG10947" /db_xref="UniProtKB/Swiss-Prot:P40747" /translation="MVKHIWDSERAAQLPKGVEELVYRSNLIGSDRTVCNWGGGNTSM KTTEKDFRGREIEVMWVKGSGSDLATMKAHNFSGLKLDDIRPLIKRDQMPDEEMVDYL SHCMIDSKHPRPSIETLLHAFLPYKHVDHTHPDAIISICCADNGKQIAEDIYGNRFVW VPYVRPGFTLSKMIAEGVANNPHAELVLMEKHGLVTWGETSETCYQKTISIIQEAEQY INDRINQHEVFGGKRYQPLPEDKRKQILAGIMPVIRGAVSEEKKMILSYDDHDDVLEF VNSVQAPALSQIGAACPDHLVHTKRVPLYIDWNPETQDVHKLADLIKSGVETFTSEYQ AYFTRNQQDGDQIFESAPRVILIPGIGMVNTGKSYAMSKVSGALYRRAIAVMKGATAL GQFVSLHENESYHVEYWPLELYKLTLAPPEAEFSRKVALITGGAGGIGSAACRRFAAE GGHVIVADLNIEGAQKIAGEINDAYGKGRAMAVKMDVTKEEDVQSAFERAALAYGGID IVVNNAGLATSSPFDETSLKEWNLNMNVLGTGYFLVAREAFKQMKHQNRGGSMVFVGS KNSVYAGKNASAYSSVKALETHLARCIAAEGGEFGIRVNSVLPDAVLQGSAIWGSSWR EERAAAYGIEPDQLEEHYRKRTALLVNIYPEDIAEAIAFFASSKAEKTTGCMITVDGG VPAAFTR*" /label="rhaE CDS" gene complement(2852975..2855044) /gene="rhaE" /locus_tag="BSU_31220" /old_locus_tag="BSU31220" /label="rhaE gene" promotor_-10 complement(2855077..2855096) /Source="Nicolas_upshift_promotors" /id="U2422" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.472527472527473" /psig=1 /xcortree=1572 /SigmaFactorBS="tttttttgttaaaaagcaaaaataaacaaaaacGATTCAAaa acaaacagaaaTCATATATAATGAAAACGGAtacaaataaaagggtatggaggaatat c" /listShort="yuxG, yulB, yulC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2855089) /Source="Nicolas_upshifts" /id="U2422" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.472527472527473" /psig=1 /xcortree=1572 /SigmaFactorBS="tttttttgttaaaaagcaaaaataaacaaaaacGATTCAAaa acaaacagaaaTCATATATAATGAAAACGGAtacaaataaaagggtatggaggaatat c" /listShort="yuxG, yulB, yulC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2855110..2855116) /Source="Nicolas_upshift_promotors" /id="U2422" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.472527472527473" /psig=1 /xcortree=1572 /SigmaFactorBS="tttttttgttaaaaagcaaaaataaacaaaaacGATTCAAaa acaaacagaaaTCATATATAATGAAAACGGAtacaaataaaagggtatggaggaatat c" /listShort="yuxG, yulB, yulC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2855182..2857170) /gene="tlpB" /locus_tag="BSU_31230" /old_locus_tag="BSU31230" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:8188684, 10825179, 14563871" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8188684, 10825179, 14563871; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="methyl-accepting chemotaxis protein" /protein_id="NP_391001.1" /db_xref="EnsemblGenomes-Gn:BSU31230" /db_xref="EnsemblGenomes-Tr:CAB15101" /db_xref="GOA:P39217" /db_xref="InterPro:IPR003122" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR033479" /db_xref="SubtiList:BG10862" /db_xref="UniProtKB/Swiss-Prot:P39217" /translation="MGKFIQWIKQPSISKPLIAAFLAVLILPVGVLAYFSYQSAWNAL DRELISSAKGNVEELNSTLQNKLEDKVKAIDYYSETVDKDILLGKNKTLLKEKFKQYT TLNDDVGAIYAASEDKKLYKYPDSGVPKGFDPTGRDWYKQAVAEKGQAVFSEPYTDEA TGDIVVTISKQLKDGSGVIALDLNLDEVLTASKRIKIGKEGFAFITTGNKKYIAHPTI KPGTTGSGDWTNQVYSKKEGSFEYTFEGKEKKMAFTTNKLTGWKIAGTYFVSELQDAS SPVLNTAVIILCVSIVIGGILILYIIRAITKPLRKLVSTSAKISSGDLTEVIDIHSKN EFGQLGESFNEMSASLRSVIGVIQTSVENVASSSEELTASAAQTSKATEHITLAIEQF SDGNEAQSEKLETSSNHLSQMNEGISKVAQASSTITKSSIQSSEAAGSGEKLVEHTVG QMKTIDQSVQKAEAVVKGLETKSQDITSILNVINGIADQTNLLALNAAIEAARAGEYG RGFSVVAEEVRKLAVQSADSAKEIEGLIQEIVREISTSLSMFQSVNHEVKEGLQITDQ TAESFKQIYEMTTQISGELQNLNATVEQLSAGSQEVSSAVEDISAVAKESSAGIQDIA ASAEEQLASMEEISSSAETLANMAEELQDITKKFKIES*" /label="tlpB CDS" gene complement(2855182..2857170) /gene="tlpB" /locus_tag="BSU_31230" /old_locus_tag="BSU31230" /label="tlpB gene" downshifts complement(2855201) /Source="Nicolas_upshifts" /id="D1616" /incds=0 /nref=108 /ntot=174 /MaxReadThrough="3.32915" /MaxDrop="6.75141" /score="18.7221191" /energy="-8.3" /TU="NA" /idTUdmin="U2423" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-35 2857174..2857181 /Source="Nicolas_upshift_promotors" /id="U2424" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.426573426573427" /psig="0.735264735264735" /xcortree=662 /SigmaFactorBS="ttgtatgaattttcccattctCGTTGACTcctcctttaagat aaATCTAATATCGTCAAACTAGgataaaaggtttaataaaaaaactaaaaaaaacacc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2857191..2857209) /Source="Nicolas_upshift_promotors" /id="U2423" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2793 /SigmaFactorBS="ttgttgcgcttgggtgttttttttagtttttttaTTAAACCT tttatcctagtttGACGATATTAGATTTATCTtaaaggaggagtcaacgagaatggga a" /listShort="tlpB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 2857197..2857216 /Source="Nicolas_upshift_promotors" /id="U2424" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.426573426573427" /psig="0.735264735264735" /xcortree=662 /SigmaFactorBS="ttgtatgaattttcccattctCGTTGACTcctcctttaagat aaATCTAATATCGTCAAACTAGgataaaaggtttaataaaaaaactaaaaaaaacacc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2857204) /Source="Nicolas_upshifts" /id="U2423" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2793 /SigmaFactorBS="ttgttgcgcttgggtgttttttttagtttttttaTTAAACCT tttatcctagtttGACGATATTAGATTTATCTtaaaggaggagtcaacgagaatggga a" /listShort="tlpB" /GFF_Attribute="listLong" /label="upshifts" upshifts 2857213 /Source="Nicolas_upshifts" /id="U2424" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.426573426573427" /psig="0.735264735264735" /xcortree=662 /SigmaFactorBS="ttgtatgaattttcccattctCGTTGACTcctcctttaagat aaATCTAATATCGTCAAACTAGgataaaaggtttaataaaaaaactaaaaaaaacacc c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2857223..2857230) /Source="Nicolas_upshift_promotors" /id="U2423" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2793 /SigmaFactorBS="ttgttgcgcttgggtgttttttttagtttttttaTTAAACCT tttatcctagtttGACGATATTAGATTTATCTtaaaggaggagtcaacgagaatggga a" /listShort="tlpB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2857279 /Source="Nicolas_upshifts" /id="D1617" /incds=0 /nref=4 /ntot=11 /MaxReadThrough="1.04089" /MaxDrop="4.2056" /score="13.4355481" /energy="-10.7" /TU="NA" /idTUdmin="U2424" /TUdmin=22 /isTUend="TRUE" /label="downshifts" CDS complement(2857284..2859269) /gene="mcpA" /locus_tag="BSU_31240" /old_locus_tag="BSU31240" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:8188684, 9721285, 12011078" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8188684, 9721285, 12011078; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="methyl-accepting chemotaxis protein" /protein_id="NP_391002.2" /db_xref="EnsemblGenomes-Gn:BSU31240" /db_xref="EnsemblGenomes-Tr:CAB15102" /db_xref="GOA:P39214" /db_xref="InterPro:IPR003122" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR033479" /db_xref="SubtiList:BG10861" /db_xref="UniProtKB/Swiss-Prot:P39214" /translation="MKKILQLIKQRSITRKLLVSFLSILIIPVVILAIFAYQSASSSL DRQMMGSALENVQQLNEIINTSIGEKENSADYFSEWLTKEKYNAKSNASIAEKFSQYI SINKDVESIYTSDTKGHFTRYPDLPMPSGYNPVERDWYKKAVANKGKVVITDPYKTAS TNTMVVTIAQQTKDGSGVIAINMTIENLLKTTKKVNIGTQGYAFIMTKDKKVVAHPNE QSGTELKGDWLDKMLSADKGDFQYTMDGDKKKMAFDTNKLTGWKIGGTMYLDEIHEAA QPVLHLALIVLAAAIIIGIIVMTLIIRSITTPLKQLVGSSKRISEGDLTETIDIRSKD ELGELGKSFNNMASSLRSLIHAIQDSVDNVAASSEELTASAAQTSKATEHITLAIEQF SNGNEKQNENIETAAEHIYQMNDGLTNMAQASEVITDSSVQSTEIASEGGKLVHQTVG QMNVIDKSVKEAEQVVRGLETKSKDITNILRVINGIADQTNLLALNAAIEAARAGEYG RGFSVVAEEVRKLAVQSADSAKEIEGLIIEIVKEINTSLGMFQSVNQEVQTGLDITDK TEMSFKRISEMTNQIAGELQNMSATVQQLSASSEEVSGASEHIASISKESSAHIQDIA ASAEEQLASMEEISSSAETLSSMAEELRDMTKRFKIE*" /label="mcpA CDS" gene complement(2857284..2859269) /gene="mcpA" /locus_tag="BSU_31240" /old_locus_tag="BSU31240" /label="mcpA gene" downshifts complement(2857289) /Source="Nicolas_upshifts" /id="D1618" /incds=0 /nref=196 /ntot=232 /MaxReadThrough="3.11319" /MaxDrop="7.54297" /score="40.6270404" /energy="-13.6" /TU="U2425" /idTUdmin="U2425" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2859290..2859308) /Source="Nicolas_upshift_promotors" /id="U2425" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2798 /SigmaFactorBS="aattagttacttttgttaaatttcttcttttttgctGTATAT ATttacccatttccaGCCGATATGAAGGGTAGCAtaaaaaaggagaaatgaatgatga a" /listShort="mcpA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2859305) /Source="Nicolas_upshifts" /id="U2425" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2798 /SigmaFactorBS="aattagttacttttgttaaatttcttcttttttgctGTATAT ATttacccatttccaGCCGATATGAAGGGTAGCAtaaaaaaggagaaatgaatgatga a" /listShort="mcpA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2859307..2859394) /Source="Nicolas_S_feature" /locus_tag="new_3208192_3208279_c" /HighExp="GM 150, T0.0H, T-1.40H, T-0.40H, MG 150, T-5.40H, T-3.40H, T-1.10H, T-2.40H, M/G" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1190" promotor_-35 complement(2859322..2859329) /Source="Nicolas_upshift_promotors" /id="U2425" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2798 /SigmaFactorBS="aattagttacttttgttaaatttcttcttttttgctGTATAT ATttacccatttccaGCCGATATGAAGGGTAGCAtaaaaaaggagaaatgaatgatga a" /listShort="mcpA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2859395..2861383) /gene="tlpA" /locus_tag="BSU_31250" /old_locus_tag="BSU31250" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:8188684, 10825179, 14563871, 26522943" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8188684, 10825179, 14563871, 26522943; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="methyl-accepting chemotaxis protein (membrane curvature dependent localisation)" /protein_id="NP_391003.1" /db_xref="EnsemblGenomes-Gn:BSU31250" /db_xref="EnsemblGenomes-Tr:CAB15103" /db_xref="GOA:P39216" /db_xref="InterPro:IPR003122" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR033479" /db_xref="SubtiList:BG10860" /db_xref="UniProtKB/Swiss-Prot:P39216" /translation="MKKTLTTIRRSSIARRLIISFLLILIVPITALSVSAYQSAVASL DVQMTQSAKENVQILDHIIDDKISTTEKSLAYFSDWATAEKFQDKKKTELKQEFKQFI QMNDNVAAVFSSGKDGDFTRYPYADMPSDFNALERDWYKEAMANKGKTIVTEPYESIS SGKMVVTIARQTVDGSGVVAIDMKIDDLVTTAKGINIGKEGYAFILSQNKKVIAYSGE KAGTELKGDWVDKLYKDKSGDFEYTYKGKKKKMAFATSQTTGWKISGTMYANEIHDAA SRVLIMASIVLAIAIGAGMTAIYFVIRSITKPLRRIVASAEKISEGDLTETIEINSKD ELGVLSESFNHMAHSLRSLIHGIKDSVEHVASSSEELTASADQTSRATEHITMAIEQF SNGSESQSEKIETTTEQINEMNDGLAELARAAAVITETSADSTEVSSKGETLVQKTAG QMNTIDHSVKAAEQVVKGLEIKSKDITNILRVINGIADQTNLLALNAAIEAARAGEYG RGFSVVAEEVRKLAVQSADSAKEIESLISEIVKEIHTSLNVLQSVNKEVETGLVMTDE TKQSFKHISQMTNQIASELQNMNATVEELSAGAQEISAASNDITAISKESSDGIQDIA ASAEEQLASMEEISSSALTLERMSEELRDLTKQFKVDK*" /label="tlpA CDS" gene complement(2859395..2861383) /gene="tlpA" /locus_tag="BSU_31250" /old_locus_tag="BSU31250" /label="tlpA gene" promotor_-10 complement(2861408..2861426) /Source="Nicolas_upshift_promotors" /id="U2426" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2835 /SigmaFactorBS="atttagaactatttttcattttttcctccattttcaATGTAA TTtaaaggaagatccGCCGATATAATTTGTAAATtattgaaagaaggttcaaaaggaa a" /listShort="tlpA, S1190" /listLong="mcpA" /label="promotor_-10" upshifts complement(2861423) /Source="Nicolas_upshifts" /id="U2426" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2835 /SigmaFactorBS="atttagaactatttttcattttttcctccattttcaATGTAA TTtaaaggaagatccGCCGATATAATTTGTAAATtattgaaagaaggttcaaaaggaa a" /listShort="tlpA, S1190" /listLong="mcpA" /label="upshifts" promotor_-35 complement(2861440..2861447) /Source="Nicolas_upshift_promotors" /id="U2426" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2835 /SigmaFactorBS="atttagaactatttttcattttttcctccattttcaATGTAA TTtaaaggaagatccGCCGATATAATTTGTAAATtattgaaagaaggttcaaaaggaa a" /listShort="tlpA, S1190" /listLong="mcpA" /label="promotor_-35" CDS complement(2861560..2863548) /gene="mcpB" /locus_tag="BSU_31260" /old_locus_tag="BSU31260" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:12011078, 14731274, 15317802, 15544802, 19901023, 20864474, 22931217, 27899502" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12011078, 14731274, 15317802, 15544802, 19901023, 20864474, 22931217, 27899502; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="methyl-accepting chemotaxis protein" /protein_id="NP_391004.2" /db_xref="EnsemblGenomes-Gn:BSU31260" /db_xref="EnsemblGenomes-Tr:CAB15104" /db_xref="GOA:P39215" /db_xref="InterPro:IPR003122" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR033479" /db_xref="SubtiList:BG10859" /db_xref="UniProtKB/Swiss-Prot:P39215" /translation="MKTFINWLKKPSISKKLIVSFIAILIIPILILEFSSYRSASGKL DQEIMGNAKNSVDTFNTTVTNDLGEKAKAVTFFSESLKRSAFKGKSNQEEIKAKFSQY VSINQGVARIYGGADNGTYVQAPKEKLPEGYDPRQRPWYQDAMKAGGEIVVTDPYVAA SDGSMVITIAQELKDGSGVVAMDITIDKLLEQMKQIKVGKEGYAFIATKNKTYVAHKN HKAGEKLSGDWVAKMYANDSGELQYTLNNEDKKMTYTTNELTGWKIAGTMYMDEIKDA SKSVLTTGMIVLIASIVAGGILILFIVRSITKPLKRLVQSSKTISRGDLTETIEIHSK DELGELGESFNEMGQSLRSLISAIQDSVNNVAASSEQLTASAGQTSKATEHITMAIEQ FSNGNEEQSEKVESSSHQLNLMNEGLQQVSQTSSDITKASIQSTEIAGTGEKFVQQTV GQMNSINQSVQQAEAVVKGLEGKSKDITSILRVINGIADQTNLLALNAAIEAARAGES GRGFSVVAEEVRKLAVQSADSAKEIEKLIQEIVAEIDTSLHMFKEVNQEVQSGLVVTD NTKESFQSIFSMTNEIAGKLQTMNSTVEQLSDRSQHVSAAVSGIADVSKESSASIQDI AASAEEQLASMEEISSSATTLAQMAEELRDLTKQFKIE*" /label="mcpB CDS" gene complement(2861560..2863548) /gene="mcpB" /locus_tag="BSU_31260" /old_locus_tag="BSU31260" /label="mcpB gene" downshifts complement(2861579) /Source="Nicolas_upshifts" /id="D1619" /incds=0 /nref=136 /ntot=224 /MaxReadThrough="3.76161" /MaxDrop="7.09773" /score="30.8363643" /energy="-10.7" /TU="U2427" /idTUdmin="U2427" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2863569..2863587) /Source="Nicolas_upshift_promotors" /id="U2427" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2799 /SigmaFactorBS="aaaaaggcagaagacagccaaaaagaacttcttccatttttt aTTTTAAAActtttttaagcaGCCGATATATACTGTATCAaacctgaaggagcaagtg a" /listShort="mcpB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2863590) /Source="Nicolas_upshifts" /id="U2427" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2799 /SigmaFactorBS="aaaaaggcagaagacagccaaaaagaacttcttccatttttt aTTTTAAAActtttttaagcaGCCGATATATACTGTATCAaacctgaaggagcaagtg a" /listShort="mcpB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2863600..2863607) /Source="Nicolas_upshift_promotors" /id="U2427" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2799 /SigmaFactorBS="aaaaaggcagaagacagccaaaaagaacttcttccatttttt aTTTTAAAActtttttaagcaGCCGATATATACTGTATCAaacctgaaggagcaagtg a" /listShort="mcpB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2863650..2863659 /Source="Nicolas_upshift_promotors" /id="U2428" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1304 /SigmaFactorBS="ggaagaagttctttttggctgtcttctgccttttTAACTTTC ATtgcccaagctcttTGCATATCTTATAAAAAACAaggggggctaaacatgattattg t" /listShort="tgl, S1191" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2863673..2863692 /Source="Nicolas_upshift_promotors" /id="U2428" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1304 /SigmaFactorBS="ggaagaagttctttttggctgtcttctgccttttTAACTTTC ATtgcccaagctcttTGCATATCTTATAAAAAACAaggggggctaaacatgattattg t" /listShort="tgl, S1191" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2863676 /Source="Nicolas_upshifts" /id="U2428" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1304 /SigmaFactorBS="ggaagaagttctttttggctgtcttctgccttttTAACTTTC ATtgcccaagctcttTGCATATCTTATAAAAAACAaggggggctaaacatgattattg t" /listShort="tgl, S1191" /GFF_Attribute="listLong" /label="upshifts" CDS 2863706..2864443 /gene="tgl" /locus_tag="BSU_31270" /old_locus_tag="BSU31270" /EC_number="2.3.2.13" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9692191, 16267299, 16751597, 16936016, 18249137, 26322858" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9692191, 16267299, 16751597, 16936016, 18249137, 26322858; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="protein-glutamine gamma-glutamyltransferase (transglutaminase)" /protein_id="NP_391005.1" /db_xref="EnsemblGenomes-Gn:BSU31270" /db_xref="EnsemblGenomes-Tr:CAB15105" /db_xref="GOA:P40746" /db_xref="InterPro:IPR020916" /db_xref="PDB:4P8I" /db_xref="PDB:4PA5" /db_xref="SubtiList:BG10946" /db_xref="UniProtKB/Swiss-Prot:P40746" /translation="MIIVSGQLLRPQDIENWQIDQDLNPLLKEMIETPVQFDYHSIAE LMFELKLRMNIVAAAKTLHKSGAKFATFLKTYGNTTYWRVSPEGALELKYRMPPSKAI RDIAENGPFYAFECATAIVIIYYLALIDTIGEDKFNASFDRIILYDWHYEKLPIYTET GHHFFLGDCLYFKNPEFDPQKAQWRGENVILLGEDKYFAHGLGILNGKQIIDKLNSFR KKGALQSAYLLSQATRLDVPSLFRIVR*" /label="tgl CDS" gene 2863706..2864443 /gene="tgl" /locus_tag="BSU_31270" /old_locus_tag="BSU31270" /label="tgl gene" promotor_-10 complement(2863731..2863750) /Source="Nicolas_upshift_promotors" /id="U2429" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.694305694305694" /psig=1 /xcortree=1815 /SigmaFactorBS="caatcatctcttttaagagcggattcagaTCTTGatcaatct gccaattTTCAATATCCTGGGGACGGAgcaattgtcctgatacaataatcatgtttag c" /GFF_Attribute="listShort" /listLong="mcpB" /label="promotor_-10" upshifts complement(2863739) /Source="Nicolas_upshifts" /id="U2429" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.694305694305694" /psig=1 /xcortree=1815 /SigmaFactorBS="caatcatctcttttaagagcggattcagaTCTTGatcaatct gccaattTTCAATATCCTGGGGACGGAgcaattgtcctgatacaataatcatgtttag c" /GFF_Attribute="listShort" /listLong="mcpB" /label="upshifts" promotor_-35 complement(2863766..2863770) /Source="Nicolas_upshift_promotors" /id="U2429" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.694305694305694" /psig=1 /xcortree=1815 /SigmaFactorBS="caatcatctcttttaagagcggattcagaTCTTGatcaatct gccaattTTCAATATCCTGGGGACGGAgcaattgtcctgatacaataatcatgtttag c" /GFF_Attribute="listShort" /listLong="mcpB" /label="promotor_-35" S_feature 2864444..2867264 /Source="Nicolas_S_feature" /locus_tag="new_3213329_3216149" /HighExp="S6, S8, S7, BT, S5, C30, B36, Pyr, BC, C90" /AntisenseName="yugT" /AntisenseCor="0.63350809138227804" /AntisenseRegPval="-30.9" /CDS_PredictionProba="0.61985900000000005" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1191" CDS complement(2864457..2864711) /gene="yuzH" /locus_tag="BSU_31279" /old_locus_tag="BSU31279" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097776.1" /db_xref="EnsemblGenomes-Gn:BSU31279" /db_xref="EnsemblGenomes-Tr:CAX52682" /db_xref="UniProtKB/Swiss-Prot:C0H3Q3" /translation="MNILQYSYKKRGKIEFVFEGWPHSKVTMVPIKGYYFVRFIKWSS QDPIVTRNDLEKMEWAANQYFGTAPFYRKRKAFETPSSGK*" /label="yuzH CDS" gene complement(2864457..2864711) /gene="yuzH" /locus_tag="BSU_31279" /old_locus_tag="BSU31279" /label="yuzH gene" downshifts complement(2864483) /Source="Nicolas_upshifts" /id="D1620" /incds=0 /nref=1 /ntot=13 /MaxReadThrough="2.39206" /MaxDrop="2.92958" /score="-2.51333596" /energy="-14.7" /TU="NA" /idTUdmin="U2430" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2864712..2864968) /Source="Nicolas_S_feature" /locus_tag="new_3213597_3213853_c" /HighExp="Etha, Sw, Salt, Gly, BC, M9-stat, Lbstat, Heat, LPhT, S0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.37980700000000001" /TUshortSig="SigB" /TUshortPSig="0.969" /TUlongSig="NA" /TUlongPSig="NA" /label="S1192" CDS complement(2864969..2865367) /gene="yugU" /locus_tag="BSU_31280" /old_locus_tag="BSU31280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391006.2" /db_xref="EnsemblGenomes-Gn:BSU31280" /db_xref="EnsemblGenomes-Tr:CAB15106" /db_xref="InterPro:IPR001602" /db_xref="InterPro:IPR035917" /db_xref="SubtiList:BG12373" /db_xref="UniProtKB/Swiss-Prot:O05243" /translation="MLKTLQIKTTKRDEMIDITREVEAFLQETGITSGAALIYCPHTT AGITINENADPDVKKDMLRRFDEVYPWEHELDRHMEGNTAAHMKSSTVGASQHVIVEN GRLILGTWQGIYFCEFDGPRTRTCYIKMMG*" /label="yugU CDS" gene complement(2864969..2865367) /gene="yugU" /locus_tag="BSU_31280" /old_locus_tag="BSU31280" /label="yugU gene" CDS complement(2865327..2865461) /locus_tag="BSU_31289" /old_locus_tag="BSU31289" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514000.1" /translation="MFYRVYESGLTGKKRTQNELSDESGQTKGETNAENTANQNNQTR *" /label="hypothetical protein CDS" gene complement(2865327..2865461) /locus_tag="BSU_31289" /old_locus_tag="BSU31289" /label="gene" promotor_-10 complement(2865410..2865429) /Source="Nicolas_upshift_promotors" /id="U2430" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.96903096903097" /psig="0.96903096903097" /xcortree=145 /SigmaFactorBS="ttagactggagtttttttgttttatcgGGTTTATgagagcgg tttaacAGGAAAAAAAAGAACACAGAacgaattaagcgatgagagcggacaaacgaaa g" /listShort="yugU, S1192, yuzH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2865417) /Source="Nicolas_upshifts" /id="U2430" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.96903096903097" /psig="0.96903096903097" /xcortree=145 /SigmaFactorBS="ttagactggagtttttttgttttatcgGGTTTATgagagcgg tttaacAGGAAAAAAAAGAACACAGAacgaattaagcgatgagagcggacaaacgaaa g" /listShort="yugU, S1192, yuzH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2865444..2865450) /Source="Nicolas_upshift_promotors" /id="U2430" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.96903096903097" /psig="0.96903096903097" /xcortree=145 /SigmaFactorBS="ttagactggagtttttttgttttatcgGGTTTATgagagcgg tttaacAGGAAAAAAAAGAACACAGAacgaattaagcgatgagagcggacaaacgaaa g" /listShort="yugU, S1192, yuzH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2865487..2867151) /gene="yugT" /locus_tag="BSU_31290" /old_locus_tag="BSU31290" /EC_number="3.2.1.10" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 1761534; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oligo-1,6-glucosidase" /protein_id="NP_391007.2" /db_xref="EnsemblGenomes-Gn:BSU31290" /db_xref="EnsemblGenomes-Tr:CAB15118" /db_xref="GOA:O05242" /db_xref="InterPro:IPR006047" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR032091" /db_xref="SubtiList:BG12372" /db_xref="UniProtKB/Swiss-Prot:O05242" /translation="MKKAWWKEAVVYQIYPRSFKDSNGDGIGDIQGIRTKLSYIKELG ADVIWICPLYDSPNADNGYDIRDYQNILSEFGTMEDFDELLGDIHDLDMKLIMDLVVN HTSDEHPWFIESRSSIHSEKRDWYIWKDGKNGKTPNNWESIFGGPAWEYDQKTSQYYL HLFDKKQPDLNWENEKVRNAVYDMINWWLDKGIDGFRVDAITHIKKKEGFPDMPNPKG LDYVPSFPYHMNADGIMDLLTELKENTFSRYPIMTVGEANGVAAKEAADWAGEKNGIF SMIFQFEHLGLWDVEINESIDIVAFKRILTDWQDSLEGIGWNALFMENHDQPRSVSVW GDDGVYLKESAKALSAVYFLMKGTPFIYQGQELGMTNVAFPSIEDYDDVALKRLYETK TAKGTSHEDVMKIVWKKGRDNSRTPMQWNAGPYAGFSEAKPWIGINENYKWLNAEAQK NDKTSVYHFYKSLIKLRQTYDVFINGTYELILPEDQQIFAYLRKNESHTALIAANLTG TPALFRHSGLPLSSDALVLSNIETEPHKHMTSVLLKPYEARIYLWC*" /label="yugT CDS" gene complement(2865487..2867151) /gene="yugT" /locus_tag="BSU_31290" /old_locus_tag="BSU31290" /label="yugT gene" downshifts complement(2865503) /Source="Nicolas_upshifts" /id="D1621" /incds=0 /nref=13 /ntot=38 /MaxReadThrough="1.79723" /MaxDrop="4.64379" /score="19.4176812" /energy="-6.5" /TU="NA" /idTUdmin="U2432" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2866459..2866478) /Source="Nicolas_upshift_promotors" /id="U2431" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.944055944055944" /psig="0.993006993006993" /xcortree=2467 /SigmaFactorBS="tttcctgacatgccgaatccaaaggGACTGGACtatgtccct tcctTTCCTTATCATATGAATGCTgacggcattatggatttgttaacagagctgaagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2866464) /Source="Nicolas_upshifts" /id="U2431" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.944055944055944" /psig="0.993006993006993" /xcortree=2467 /SigmaFactorBS="tttcctgacatgccgaatccaaaggGACTGGACtatgtccct tcctTTCCTTATCATATGAATGCTgacggcattatggatttgttaacagagctgaagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2866492..2866499) /Source="Nicolas_upshift_promotors" /id="U2431" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.944055944055944" /psig="0.993006993006993" /xcortree=2467 /SigmaFactorBS="tttcctgacatgccgaatccaaaggGACTGGACtatgtccct tcctTTCCTTATCATATGAATGCTgacggcattatggatttgttaacagagctgaagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2867176..2867194) /Source="Nicolas_upshift_promotors" /id="U2432" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1123 /SigmaFactorBS="gctgttttttgtgtcatcaagtcatttcttaaaaagcaATGC TGtaaagacctttttctACATAGGATATATAAGAACggtacactgggaaggagtggct g" /listShort="yugT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2867193) /Source="Nicolas_upshifts" /id="U2432" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1123 /SigmaFactorBS="gctgttttttgtgtcatcaagtcatttcttaaaaagcaATGC TGtaaagacctttttctACATAGGATATATAAGAACggtacactgggaaggagtggct g" /listShort="yugT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2867210..2867215) /Source="Nicolas_upshift_promotors" /id="U2432" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=1123 /SigmaFactorBS="gctgttttttgtgtcatcaagtcatttcttaaaaagcaATGC TGtaaagacctttttctACATAGGATATATAAGAACggtacactgggaaggagtggct g" /listShort="yugT" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2867278..2868567) /gene="yugS" /locus_tag="BSU_31300" /old_locus_tag="BSU31300" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative membrane protein" /protein_id="NP_391008.2" /db_xref="EnsemblGenomes-Gn:BSU31300" /db_xref="EnsemblGenomes-Tr:CAB15119" /db_xref="GOA:O05241" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR002550" /db_xref="InterPro:IPR005170" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR036318" /db_xref="SubtiList:BG12371" /db_xref="UniProtKB/Swiss-Prot:O05241" /translation="MLILQLIAIFVLIGITAVFVAAEFAIVKIRGSKINQLIESGDSR ALAAHKIISNLDEYLSACQLGITITALGLGWLGEPTFERFLHPLFTMTGIPEPFNHIV TFVVAFIIVTFLHVVMGELAPKTVSIQKAEAVSLWIAKPLIWFYKITYPFIKALNGSA SFLVKLFGFHSVKEHQVVISEEELRLILSESYEKGEINQSEFRYVNKIFEFDNRVARE IMIPRTEIAVISLEQSLEEAIHHIINERYTRYPVIKDDKDHILGIINSKDMFKAYFLG QPIKLNQIMRPVIRVIESIPVQQLLIRMQKERIHMAILVDEYGGTAGLVTVEDIIEEI VGEIRDEYDQDETPHILKKGEHHYVMDGKALIDEVNDLLDIAIENEEIDTIAGWLLTQ KMELKAGDVIHAEGCEFKILDAEDHHIRFVEIKKTDF*" /label="yugS CDS" gene complement(2867278..2868567) /gene="yugS" /locus_tag="BSU_31300" /old_locus_tag="BSU31300" /label="yugS gene" downshifts complement(2867287) /Source="Nicolas_upshifts" /id="D1622" /incds=0 /nref=5 /ntot=28 /MaxReadThrough="0.89237" /MaxDrop="3.67001" /score="3.60520478" /energy="-7.6" /TU="NA" /idTUdmin="U2434" /TUdmin=13 /isTUend="TRUE" /label="downshifts" promotor_-35 2868096..2868102 /Source="Nicolas_upshift_promotors" /id="U2433" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=254 /SigmaFactorBS="aagccaaacaatttcacaagaaaacttgcagagcCGTTTAAt gctttaataaacGGGTACGTGATTTTATAAAaccagatcagcggctttgcaatccata a" /listShort="S1193" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2868116..2868134 /Source="Nicolas_upshift_promotors" /id="U2433" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=254 /SigmaFactorBS="aagccaaacaatttcacaagaaaacttgcagagcCGTTTAAt gctttaataaacGGGTACGTGATTTTATAAAaccagatcagcggctttgcaatccata a" /listShort="S1193" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2868122 /Source="Nicolas_upshifts" /id="U2433" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=254 /SigmaFactorBS="aagccaaacaatttcacaagaaaacttgcagagcCGTTTAAt gctttaataaacGGGTACGTGATTTTATAAAaccagatcagcggctttgcaatccata a" /listShort="S1193" /GFF_Attribute="listLong" /label="upshifts" S_feature 2868126..2868778 /Source="Nicolas_S_feature" /locus_tag="new_3217011_3217663" /HighExp="Etha, Sw, Gly, Salt, BC, B60, Heat, S8, B36, HiTm" /AntisenseName="yugS" /AntisenseCor="0.12310225183111501" /AntisenseRegPval="-1.4" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1193" CDS complement(2868611..2869288) /gene="yugP" /locus_tag="BSU_31310" /old_locus_tag="BSU31310" /function="16.6: Maintain" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16704729, 16850406, 24383880; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent protease/peptidase" /protein_id="NP_391009.1" /db_xref="EnsemblGenomes-Gn:BSU31310" /db_xref="EnsemblGenomes-Tr:CAB15120" /db_xref="GOA:O05248" /db_xref="InterPro:IPR007395" /db_xref="SubtiList:BG12370" /db_xref="UniProtKB/Swiss-Prot:O05248" /translation="MLFIFLTIAALGLSFWAQFKVKSNFEKYSKVEASSGRTGAETAR RILDINGLYDVPVEPVRGTLTDHYDPTRRVVRLSEPVYYGRSISAISVASHEVGHALQ HQESYGALVLRHKIFPVVNFASGVAPLLFLGGMLLGSLNLIGLGIILFSAAVFFQLIT LPVEFNASSRAKQIIVSEGFIRNNEENGVNKVLSAAALTYVAAALVSLFELLRFVMIF LNGRDEN*" /label="yugP CDS" gene complement(2868611..2869288) /gene="yugP" /locus_tag="BSU_31310" /old_locus_tag="BSU31310" /label="yugP gene" downshifts complement(2868621) /Source="Nicolas_upshifts" /id="D1623" /incds=0 /nref=153 /ntot=249 /MaxReadThrough="3.51629" /MaxDrop="4.854" /score="33.0420688" /energy="-13" /TU="U2434,U2435" /idTUdmin="U2435" /TUdmin="-243" /isTUend="FALSE" /label="downshifts" S_feature 2868963..2869639 /Source="Nicolas_S_feature" /locus_tag="new_3217848_3218524" /HighExp="Sw, S8, Salt, BC, S7, Etha, Gly, B36, B60, LPhT" /AntisenseName="yuzI" /AntisenseCor="0.20035821815170399" /AntisenseRegPval="-3" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1194" promotor_-10 complement(2869323..2869342) /Source="Nicolas_upshift_promotors" /id="U2434" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig="0.999000999001" /xcortree=2033 /SigmaFactorBS="ctgattggattgtgtgctccaagccggaagaaaaagcgcatT TCTGTACacgagaaagaaaaCTCATTAAAATAATCGTAATagagaaatgatcatgaac a" /listShort="yugP, yugS" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2869330..2869593) /gene="yuzI" /locus_tag="BSU_31319" /old_locus_tag="BSU31319" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16704729; Product type f : factor" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097777.1" /db_xref="EnsemblGenomes-Gn:BSU31319" /db_xref="EnsemblGenomes-Tr:CAX52683" /db_xref="GOA:C0H3Q4" /db_xref="UniProtKB/Swiss-Prot:C0H3Q4" /translation="MTIFQRTIVVLIGTQLAASAVILFIFDLNSYNHFSGSFSWLHFL KELAGSFAFYLFSAGLFFLLIGLCAPSRKKKRISVHEKENSLK*" /label="yuzI CDS" gene complement(2869330..2869593) /gene="yuzI" /locus_tag="BSU_31319" /old_locus_tag="BSU31319" /label="yuzI gene" upshifts complement(2869344) /Source="Nicolas_upshifts" /id="U2434" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig="0.999000999001" /xcortree=2033 /SigmaFactorBS="ctgattggattgtgtgctccaagccggaagaaaaagcgcatT TCTGTACacgagaaagaaaaCTCATTAAAATAATCGTAATagagaaatgatcatgaac a" /listShort="yugP, yugS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2869356..2869363) /Source="Nicolas_upshift_promotors" /id="U2434" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig="0.999000999001" /xcortree=2033 /SigmaFactorBS="ctgattggattgtgtgctccaagccggaagaaaaagcgcatT TCTGTACacgagaaagaaaaCTCATTAAAATAATCGTAATagagaaatgatcatgaac a" /listShort="yugP, yugS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2869605..2869623) /Source="Nicolas_upshift_promotors" /id="U2435" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1079 /SigmaFactorBS="cccacttccggtgatgtttttcaaaaaatgtacaaAACATAt aaaaccggatttctCCATAAACTAAAACAAAAAggatgaaaaagatgacgatctttca a" /listShort="yuzI, yugP, yugS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2869619) /Source="Nicolas_upshifts" /id="U2435" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1079 /SigmaFactorBS="cccacttccggtgatgtttttcaaaaaatgtacaaAACATAt aaaaccggatttctCCATAAACTAAAACAAAAAggatgaaaaagatgacgatctttca a" /listShort="yuzI, yugP, yugS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2869639..2869644) /Source="Nicolas_upshift_promotors" /id="U2435" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1079 /SigmaFactorBS="cccacttccggtgatgtttttcaaaaaatgtacaaAACATAt aaaaccggatttctCCATAAACTAAAACAAAAAggatgaaaaagatgacgatctttca a" /listShort="yuzI, yugP, yugS" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2869640..2869972 /gene="mstX" /locus_tag="BSU_31321" /old_locus_tag="BSU31321" /function="16.5: Explore" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15731457, 23737939, 25297828" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15731457, 23737939, 25297828; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="atypical membrane-integrating regulator of biofilm formation (Mistic protein)" /protein_id="YP_003097778.1" /db_xref="EnsemblGenomes-Gn:BSU31321" /db_xref="EnsemblGenomes-Tr:CAX52684" /db_xref="GOA:Q5BU39" /db_xref="InterPro:IPR021078" /db_xref="PDB:1YGM" /db_xref="UniProtKB/Swiss-Prot:Q5BU39" /translation="MFCTFFEKHHRKWDILLEKSTGVMEAMKVTSEEKEQLSTAIDRM NEGLDAFIQLYNESEIDEPLIQLDDDTAELMKQARDMYGQEKLNEKLNTIIKQILSIS VSEEGEKE*" /label="mstX CDS" gene 2869640..2869972 /gene="mstX" /locus_tag="BSU_31321" /old_locus_tag="BSU31321" /label="mstX gene" promotor_-35 2869657..2869663 /Source="Nicolas_upshift_promotors" /id="U2436" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.497502497502497" /psig="0.497502497502497" /xcortree=1012 /SigmaFactorBS="tccggttttatatgttttgtacatttttTGAAAAAcatcacc ggaagtgGGACATACTGTTAGAAAAaagcacgggtgtgatggaagctatgaaagtgac g" /listShort="mstX, yugO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2869678..2869695 /Source="Nicolas_upshift_promotors" /id="U2436" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.497502497502497" /psig="0.497502497502497" /xcortree=1012 /SigmaFactorBS="tccggttttatatgttttgtacatttttTGAAAAAcatcacc ggaagtgGGACATACTGTTAGAAAAaagcacgggtgtgatggaagctatgaaagtgac g" /listShort="mstX, yugO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2869689 /Source="Nicolas_upshifts" /id="U2436" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.497502497502497" /psig="0.497502497502497" /xcortree=1012 /SigmaFactorBS="tccggttttatatgttttgtacatttttTGAAAAAcatcacc ggaagtgGGACATACTGTTAGAAAAaagcacgggtgtgatggaagctatgaaagtgac g" /listShort="mstX, yugO" /GFF_Attribute="listLong" /label="upshifts" CDS 2869969..2870955 /gene="kbfO" /locus_tag="BSU_31322" /old_locus_tag="BSU31322" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16704729, 23737939, 25297828" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16704729, 23737939, 25297828; Product type t: transporter" /codon_start=1 /transl_table=11 /product="potassium channel protein involved in biofilm formation" /protein_id="NP_391010.3" /db_xref="EnsemblGenomes-Gn:BSU31322" /db_xref="EnsemblGenomes-Tr:CAB15121" /db_xref="GOA:Q795M8" /db_xref="InterPro:IPR003148" /db_xref="InterPro:IPR013099" /db_xref="InterPro:IPR028325" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12369" /db_xref="UniProtKB/Swiss-Prot:Q795M8" /translation="MKSNRIFISWLRWPLFIRIGVIILCLILLFGQIIYILEPKQFTS VFEGIWWAVVTVSTVGYGDYVPHTPLGQAAGILLILSGASFVTAYFATLSAAAFSRQH RYIEGKVAYKGRDHIILIGWNEKTNRLLKDLQLAAPSKTVVLIDESLTEGPLIENVHF IRGHAADDGTLKRANITEAESVMITADQYKSETDADMLSVLTLLSVKGLNPLAYCIVE ILTDRFVTNAERAGANQIIGTSEFISRAMLQHYQVKLRPSKQQNGIKLTLDQHVELLA VPDELKGAAYKTCVLYFLDHNTTIIGIQKKEGPMLSPPLTYKVLETDQFLAI*" /label="kbfO CDS" gene 2869969..2870955 /gene="kbfO" /locus_tag="BSU_31322" /old_locus_tag="BSU31322" /label="kbfO gene" downshifts complement(2870930) /Source="Nicolas_upshifts" /id="D1624" /incds=0 /nref=44 /ntot=128 /MaxReadThrough="0.617940000000001" /MaxDrop="4.76695" /score="21.5904825" /energy="-11.3" /TU="NA" /idTUdmin="U2437" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2870952..2871356) /gene="yugN" /locus_tag="BSU_31330" /old_locus_tag="BSU31330" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391011.1" /db_xref="EnsemblGenomes-Gn:BSU31330" /db_xref="EnsemblGenomes-Tr:CAB15122" /db_xref="InterPro:IPR014967" /db_xref="InterPro:IPR036491" /db_xref="SubtiList:BG12368" /db_xref="UniProtKB/Swiss-Prot:O05246" /translation="MIPIPSAIDGQSFLLQELEQVMKPLGYVINGGWEYDHGYFDYKI DDRDGYLFLRIPVNAVQGSLDERGAAVRIGTPFMLRQVFQADVDDHAEGGPFQSLFNQ FSEPERRDAEIDPAFLDIGASLVKELEDVLLH*" /label="yugN CDS" gene complement(2870952..2871356) /gene="yugN" /locus_tag="BSU_31330" /old_locus_tag="BSU31330" /label="yugN gene" S_feature complement(2871357..2871415) /Source="Nicolas_S_feature" /locus_tag="new_3220242_3220300_c" /HighExp="M0t90, M40t90, S6, S8, S7, T0.30H, Lbstat, M9-stat, T1.30H, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, Sig-, SigA" /TUshortPSig="0.686, 0.141, 0.984" /TUlongSig="SigA" /TUlongPSig="0.988" /label="S1195" CDS complement(2871416..2871787) /gene="yugM" /locus_tag="BSU_31340" /old_locus_tag="BSU31340" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_391012.1" /db_xref="EnsemblGenomes-Gn:BSU31340" /db_xref="EnsemblGenomes-Tr:CAB15123" /db_xref="GOA:O05245" /db_xref="SubtiList:BG12367" /db_xref="UniProtKB/Swiss-Prot:O05245" /translation="MFMKQLVKHLIIAGFSAAILSFLISFDAVYTGFSSSFGGTLSHF FIHSFLLIGLPLALFTDAVHRILHLKRTHTLFTKLGLYATVVYVSWDSAVWLAAAMAV YFLIECAFFPVGRAKETTISM*" /label="yugM CDS" gene complement(2871416..2871787) /gene="yugM" /locus_tag="BSU_31340" /old_locus_tag="BSU31340" /label="yugM gene" CDS complement(2871846..2873198) /gene="pgi" /locus_tag="BSU_31350" /old_locus_tag="BSU31350" /EC_number="5.3.1.9" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 4214896, 4275311, 11489127, 19052382, 21453533, 22720735, 24705866; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucose-6-phosphate isomerase" /protein_id="NP_391013.2" /db_xref="EnsemblGenomes-Gn:BSU31350" /db_xref="EnsemblGenomes-Tr:CAB15124" /db_xref="GOA:P80860" /db_xref="InterPro:IPR001672" /db_xref="InterPro:IPR018189" /db_xref="InterPro:IPR035476" /db_xref="InterPro:IPR035482" /db_xref="SubtiList:BG12366" /db_xref="UniProtKB/Swiss-Prot:P80860" /translation="MTHVRFDYSKALTFFNEHELTYLRDFVKTAHHNIHEKTGAGSDF LGWVDLPEHYDKEEFARIKKSAEKIKSDSDVLLVVGIGGSYLGARAAIEALNHAFYNT LPKAKRGNPQVIFIGNNISSSYMRDVMDLLEDVDFSINVISKSGTTTEPAIAFRIFRK LLEEKYGKEEAKARIYATTDKERGALKTLSNEEGFESFVIPDDVGGRYSVLTAVGLLP IAVSGVNIDDMMKGALDASKDFATSELEDNPAYQYAVVRNVLYNKGKTIEMLINYEPA LQYFAEWWKQLFGESEGKDEKGIYPSSANYSTDLHSLGQYVQEGRRDLFETVLNVEKP KHELTIEEADNDLDGLNYLAGKTVDFVNKKAFQGTMLAHTDGNVPNLIVNIPELNAYT FGYLVYFFEKACAMSGYLLGVNPFDQPGVEAYKVNMFALLGKPGFEEKKAELEKRLED *" /label="pgi CDS" gene complement(2871846..2873198) /gene="pgi" /locus_tag="BSU_31350" /old_locus_tag="BSU31350" /label="pgi gene" downshifts complement(2871857) /Source="Nicolas_upshifts" /id="D1625" /incds=0 /nref=90 /ntot=198 /MaxReadThrough="6.86736" /MaxDrop="4.4585" /score="24.139293" /energy="-16.8" /TU="U2437,U2438,U2439" /idTUdmin="U2441" /TUdmin=19 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2872013..2872031) /Source="Nicolas_upshift_promotors" /id="U2437" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.686313686313686" /psig="0.686313686313686" /xcortree=764 /SigmaFactorBS="tgcttgcccatacagacggaaatgttccgaacttaatcGTTA ACattcctgagctgaatGCATATACTTTTGGATACCttgtatatttcttcgaaaaagc c" /listShort="yugM, S1195, yugN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2872030) /Source="Nicolas_upshifts" /id="U2437" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.686313686313686" /psig="0.686313686313686" /xcortree=764 /SigmaFactorBS="tgcttgcccatacagacggaaatgttccgaacttaatcGTTA ACattcctgagctgaatGCATATACTTTTGGATACCttgtatatttcttcgaaaaagc c" /listShort="yugM, S1195, yugN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2872047..2872052) /Source="Nicolas_upshift_promotors" /id="U2437" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.686313686313686" /psig="0.686313686313686" /xcortree=764 /SigmaFactorBS="tgcttgcccatacagacggaaatgttccgaacttaatcGTTA ACattcctgagctgaatGCATATACTTTTGGATACCttgtatatttcttcgaaaaagc c" /listShort="yugM, S1195, yugN" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2873171) /Source="Nicolas_upshifts" /id="U2438" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.325674325674326" /psig="0.140859140859141" /xcortree=1777 /SigmaFactorBS="tgaaaacattataccgttatggagggacaagcaatgacgcat gtacGCTTTGACTACTcaaaagcgttgactttcttcaacgaacatgaacttacatacc t" /listShort="pgi, yugM, S1195, yugN" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(2873174..2873185) /Source="Nicolas_upshift_promotors" /id="U2438" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.325674325674326" /psig="0.140859140859141" /xcortree=1777 /SigmaFactorBS="tgaaaacattataccgttatggagggacaagcaatgacgcat gtacGCTTTGACTACTcaaaagcgttgactttcttcaacgaacatgaacttacatacc t" /listShort="pgi, yugM, S1195, yugN" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(2873230..2873249) /Source="Nicolas_upshift_promotors" /id="U2439" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.984015984015984" /xcortree=2224 /SigmaFactorBS="aatccagtcattccgccctttcttcttgaCTTGatttcacag ataagTTCATATAAAGTGAAAGATGaaaacattataccgttatggagggacaagcaat g" /listShort="pgi, yugM, S1195, yugN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2873236) /Source="Nicolas_upshifts" /id="U2439" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.984015984015984" /xcortree=2224 /SigmaFactorBS="aatccagtcattccgccctttcttcttgaCTTGatttcacag ataagTTCATATAAAGTGAAAGATGaaaacattataccgttatggagggacaagcaat g" /listShort="pgi, yugM, S1195, yugN" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2873238..2873309) /Source="Nicolas_S_feature" /locus_tag="new_3222123_3222194_c" /HighExp="Etha, H2O2, Paraq, Oxctl, G180, G150, dia5, dia15, G135, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 0.988" /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S1196" promotor_-35 complement(2873264..2873267) /Source="Nicolas_upshift_promotors" /id="U2439" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.984015984015984" /xcortree=2224 /SigmaFactorBS="aatccagtcattccgccctttcttcttgaCTTGatttcacag ataagTTCATATAAAGTGAAAGATGaaaacattataccgttatggagggacaagcaat g" /listShort="pgi, yugM, S1195, yugN" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2873310..2874482) /gene="bdhK" /locus_tag="BSU_31360" /old_locus_tag="BSU31360" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1385386, 1809209, 2673038; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADH-dependent butanol dehydrogenase subunit" /protein_id="NP_391014.1" /db_xref="EnsemblGenomes-Gn:BSU31360" /db_xref="EnsemblGenomes-Tr:CAB15125" /db_xref="GOA:O05240" /db_xref="InterPro:IPR001670" /db_xref="InterPro:IPR018211" /db_xref="SubtiList:BG12365" /db_xref="UniProtKB/Swiss-Prot:O05240" /translation="MENFTYYNPTKLIFGKGQLEQLRKEFKRYGKNVLLVYGGGSIKR NGLYDQVTGILKEEGAVVHELSGVEPNPRLATVEKGIGLCREHDIDFLLAVGGGSVID CTKAIAAGVKYDGDAWDIFSKKVTAEDALPFGTVLTLAATGSEMNPDSVITNWETNEK FVWGSNVTHPRFSILDPENTFTVPENQTVYGMVDMMSHVFEQYFHNVENTPLQDRMCF AVLQTVIETAPKLLEDLENYELRETILYAGTIALNGTLQMGYFGDWASHTMEHAVSAV YDIPHAGGLAILFPNWMRYTLDTNVGRFKNLMLNMFDIDTEGKTDKEIALEGIDKLSA FWTSLGAPSRLADYNIGEEKLELIADIAAKEMEHGGFGNFQKLNKDDVLAILRASL*" /label="bdhK CDS" gene complement(2873310..2874482) /gene="bdhK" /locus_tag="BSU_31360" /old_locus_tag="BSU31360" /label="bdhK gene" S_feature 2873645..2874566 /Source="Nicolas_S_feature" /locus_tag="new_3222530_3223451" /HighExp="S6, S7, S8, BT, S5, C30, LBGstat, B36, G135, G150" /AntisenseName="yugK" /AntisenseCor="4.31382473780575E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1197" promotor_-10 complement(2874515..2874534) /Source="Nicolas_upshift_promotors" /id="U2440" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.81018981018981" /psig="0.999000999001" /xcortree=2474 /SigmaFactorBS="taaaaaaaggggaaatagccgtttggctgcttccCTTTttct tttttgtcaactTATGTTACAATGGAAAATCTgttttttaccagcatcatttggaggt t" /listShort="yugK, S1196" /listLong="pgi" /label="promotor_-10" upshifts complement(2874528) /Source="Nicolas_upshifts" /id="U2440" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.81018981018981" /psig="0.999000999001" /xcortree=2474 /SigmaFactorBS="taaaaaaaggggaaatagccgtttggctgcttccCTTTttct tttttgtcaactTATGTTACAATGGAAAATCTgttttttaccagcatcatttggaggt t" /listShort="yugK, S1196" /listLong="pgi" /label="upshifts" promotor_-35 complement(2874551..2874554) /Source="Nicolas_upshift_promotors" /id="U2440" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.81018981018981" /psig="0.999000999001" /xcortree=2474 /SigmaFactorBS="taaaaaaaggggaaatagccgtttggctgcttccCTTTttct tttttgtcaactTATGTTACAATGGAAAATCTgttttttaccagcatcatttggaggt t" /listShort="yugK, S1196" /listLong="pgi" /label="promotor_-35" CDS complement(2874586..2875749) /gene="bdhJ" /locus_tag="BSU_31370" /old_locus_tag="BSU31370" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1385386, 2673038, 9643546, 11466286, 15317791; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADH-dependent butanol dehydrogenase" /protein_id="NP_391015.1" /db_xref="EnsemblGenomes-Gn:BSU31370" /db_xref="EnsemblGenomes-Tr:CAB15126" /db_xref="GOA:O05239" /db_xref="InterPro:IPR001670" /db_xref="InterPro:IPR018211" /db_xref="SubtiList:BG12364" /db_xref="UniProtKB/Swiss-Prot:O05239" /translation="MQNFTYWNPTKLIFGRGEVERLPEELKPYGKNVLLVYGGGSIKR SGLYDQVIEQLNKAGATVHELAGVEPNPRVSTVNKGVAICKEQNIDFLLAVGGGSVID CTKAIAAGAKYDGDAWDIVTKKHQPKDALPFGTVLTLAATGSEMNSGSVITNWETKEK YGWGSPLVFPKFSILDPVNTFTVPKNHTIYGMVDMMSHVFEQYFHHVSNTPYQDRMCE SLLRTVIETAPKLINDLENYELRETILYTGTIALNGMLSMGARGDWATHNIEHAVSAV YDIPHAGGLAILFPNWMRHTLSENPARMKQLAVRVFDVEEAGKTDEEIALEGIDKLSA FWTSLGAPNRLADYDINDEQLDTIADKAMANGTFGQFKSLNKEDVLSILKASL*" /label="bdhJ CDS" gene complement(2874586..2875749) /gene="bdhJ" /locus_tag="BSU_31370" /old_locus_tag="BSU31370" /label="bdhJ gene" downshifts complement(2874601) /Source="Nicolas_upshifts" /id="D1626" /incds=0 /nref=167 /ntot=237 /MaxReadThrough="6.69366" /MaxDrop="4.74696" /score="28.8200012" /energy="-13.4" /TU="U2441" /idTUdmin="U2444" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2875764..2875783) /Source="Nicolas_upshift_promotors" /id="U2441" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.803196803196803" /psig="0.988011988011988" /xcortree=1943 /SigmaFactorBS="ataaaaccatctggtatgctgatcggtgagagctgatTGCTT TACatgtggtgaggacaTTCTGCATAATAAAAAATCTaaggaggagatgtcatgcaaa a" /listShort="yugJ, yugK, S1196, pgi" /listLong="yugM, S1195, yugN" /label="promotor_-10" upshifts complement(2875782) /Source="Nicolas_upshifts" /id="U2441" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.803196803196803" /psig="0.988011988011988" /xcortree=1943 /SigmaFactorBS="ataaaaccatctggtatgctgatcggtgagagctgatTGCTT TACatgtggtgaggacaTTCTGCATAATAAAAAATCTaaggaggagatgtcatgcaaa a" /listShort="yugJ, yugK, S1196, pgi" /listLong="yugM, S1195, yugN" /label="upshifts" S_feature complement(2875784..2875939) /Source="Nicolas_S_feature" /locus_tag="new_3224669_3224824_c" /HighExp="S8, S7, S4, S5, S6, LoTm, Cold, LBGtran, G180, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.25658199999999998" /TUshortSig="SigGF, SigA" /TUshortPSig="0.679, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S1198" promotor_-35 complement(2875798..2875805) /Source="Nicolas_upshift_promotors" /id="U2441" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.803196803196803" /psig="0.988011988011988" /xcortree=1943 /SigmaFactorBS="ataaaaccatctggtatgctgatcggtgagagctgatTGCTT TACatgtggtgaggacaTTCTGCATAATAAAAAATCTaaggaggagatgtcatgcaaa a" /listShort="yugJ, yugK, S1196, pgi" /listLong="yugM, S1195, yugN" /label="promotor_-35" promotor_-35 2875835..2875841 /Source="Nicolas_upshift_promotors" /id="U2442" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=195 /SigmaFactorBS="atcagctctcaccgatcagcataccagatGGTTTTAttttgc aaggtgctGGGAAAGAAGCTGATATAAgcgagggcaggccagcttccctcatatggag a" /listShort="S1199, yuzA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2875856..2875874 /Source="Nicolas_upshift_promotors" /id="U2442" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=195 /SigmaFactorBS="atcagctctcaccgatcagcataccagatGGTTTTAttttgc aaggtgctGGGAAAGAAGCTGATATAAgcgagggcaggccagcttccctcatatggag a" /listShort="S1199, yuzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2875866 /Source="Nicolas_upshifts" /id="U2442" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=195 /SigmaFactorBS="atcagctctcaccgatcagcataccagatGGTTTTAttttgc aaggtgctGGGAAAGAAGCTGATATAAgcgagggcaggccagcttccctcatatggag a" /listShort="S1199, yuzA" /GFF_Attribute="listLong" /label="upshifts" S_feature 2875867..2875925 /Source="Nicolas_S_feature" /locus_tag="new_3224752_3224810" /HighExp="Etha, Salt, Heat, M9-stat, LPhT, Sw, Gly, BC, HiTm, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1199" promotor_-35 2875912..2875918 /Source="Nicolas_upshift_promotors" /id="U2443" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.814185814185814" /psig="0.814185814185814" /xcortree=734 /SigmaFactorBS="tgatataagcgagggcaggccagcttccctcatatggagaat gcaTGTATAGattctccaatatgTCACAATCTATAactgttttaataattcatggagg a" /listShort="yuzA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2875914..2875925) /Source="Nicolas_upshift_promotors" /id="U2444" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.679320679320679" /psig="0.679320679320679" /xcortree=897 /SigmaFactorBS="aattctttgaatggtactcatgttttgcaacctcctccatga attattaaaacaGTTATAGattgtgacatattGGAGAATCTATAcatgcattctccat a" /listShort="S1198, yugJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2875927 /Source="Nicolas_upshifts" /id="U2443" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.814185814185814" /psig="0.814185814185814" /xcortree=734 /SigmaFactorBS="tgatataagcgagggcaggccagcttccctcatatggagaat gcaTGTATAGattctccaatatgTCACAATCTATAactgttttaataattcatggagg a" /listShort="yuzA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2875932..2875943 /Source="Nicolas_upshift_promotors" /id="U2443" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.814185814185814" /psig="0.814185814185814" /xcortree=734 /SigmaFactorBS="tgatataagcgagggcaggccagcttccctcatatggagaat gcaTGTATAGattctccaatatgTCACAATCTATAactgttttaataattcatggagg a" /listShort="yuzA" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2875939..2875945) /Source="Nicolas_upshift_promotors" /id="U2444" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.679320679320679" /psig="0.679320679320679" /xcortree=897 /SigmaFactorBS="aattctttgaatggtactcatgttttgcaacctcctccatga attattaaaacaGTTATAGattgtgacatattGGAGAATCTATAcatgcattctccat a" /listShort="S1198, yugJ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2875939) /Source="Nicolas_upshifts" /id="U2444" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.679320679320679" /psig="0.679320679320679" /xcortree=897 /SigmaFactorBS="aattctttgaatggtactcatgttttgcaacctcctccatga attattaaaacaGTTATAGattgtgacatattGGAGAATCTATAcatgcattctccat a" /listShort="S1198, yugJ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2875941..2876252) /Source="Nicolas_S_feature" /locus_tag="new_3224826_3225137_c" /HighExp="Cold, LBGtran, LoTm, G180, LBGexp, dia15, G135, H2O2, Paraq, Oxctl" /AntisenseName="yuzA" /AntisenseCor="-0.50065532030853999" /AntisenseRegPval="-17.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1200" CDS 2875979..2876215 /gene="yuzA" /locus_tag="BSU_31380" /old_locus_tag="BSU31380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391016.1" /db_xref="EnsemblGenomes-Gn:BSU31380" /db_xref="EnsemblGenomes-Tr:CAB15127" /db_xref="GOA:O32087" /db_xref="InterPro:IPR007211" /db_xref="SubtiList:BG14050" /db_xref="UniProtKB/Swiss-Prot:O32087" /translation="MSTIQRICLVLTIIGAINWGLIGFFQFDLVAAIFGGQGSALSRI IYGLVGIAGLINLGLLFKPNEERSREEAANPEMR*" /label="yuzA CDS" gene 2875979..2876215 /gene="yuzA" /locus_tag="BSU_31380" /old_locus_tag="BSU31380" /label="yuzA gene" downshifts 2876175 /Source="Nicolas_upshifts" /id="D1627" /incds=0 /nref=3 /ntot=45 /MaxReadThrough="7.39676" /MaxDrop="2.87922" /score="13.9936296" /energy="-12" /TU="U2442,U2443" /idTUdmin="U2442" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" downshifts 2876241 /Source="Nicolas_upshifts" /id="D1628" /incds=0 /nref=25 /ntot=56 /MaxReadThrough="1.29261" /MaxDrop="7.50276" /score="13.9936296" /energy="-12" /TU="NA" /idTUdmin="U2442" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2876293..2876685) /gene="yugI" /locus_tag="BSU_31390" /old_locus_tag="BSU31390" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9862121, 16014871, 19152054, 19636895; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative RNA degradation protein; putative phosphorylase or nucleotidyl transferase; general stress protein" /protein_id="NP_391017.1" /db_xref="EnsemblGenomes-Gn:BSU31390" /db_xref="EnsemblGenomes-Tr:CAB15128" /db_xref="GOA:P80870" /db_xref="InterPro:IPR003029" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR022967" /db_xref="PDB:2K4K" /db_xref="SubtiList:BG12363" /db_xref="UniProtKB/Swiss-Prot:P80870" /translation="MAAKFEVGSVYTGKVTGLQAYGAFVALDEETQGLVHISEVTHGF VKDINEHLSVGDEVQVKVLAVDEEKGKISLSIRATQAAPEKKESKPRKPKAAQVSEEA STPQGFNTLKDKLEEWIEMSNRKDLIKK*" /label="yugI CDS" gene complement(2876293..2876685) /gene="yugI" /locus_tag="BSU_31390" /old_locus_tag="BSU31390" /label="yugI gene" downshifts complement(2876297) /Source="Nicolas_upshifts" /id="D1629" /incds=0 /nref=232 /ntot=268 /MaxReadThrough="5.9665" /MaxDrop="6.0195" /score="13.5952751" /energy="-15.6" /TU="U2445" /idTUdmin="U2448" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2876727..2876746) /Source="Nicolas_upshift_promotors" /id="U2445" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.921078921078921" /psig=1 /xcortree=2503 /SigmaFactorBS="taaacctgattttttataaaaaagttttCTTTGcggaaataa gacatgTGTGATATAATTTTAAATTGcgtataaacagatatttaatttaacttaggag t" /listShort="yugI, S1200, S1198, yugJ" /listLong="yugK, S1196, pgi, yugM" /label="promotor_-10" upshifts complement(2876734) /Source="Nicolas_upshifts" /id="U2445" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.921078921078921" /psig=1 /xcortree=2503 /SigmaFactorBS="taaacctgattttttataaaaaagttttCTTTGcggaaataa gacatgTGTGATATAATTTTAAATTGcgtataaacagatatttaatttaacttaggag t" /listShort="yugI, S1200, S1198, yugJ" /listLong="yugK, S1196, pgi, yugM" /label="upshifts" S_feature complement(2876736..2876886) /Source="Nicolas_S_feature" /locus_tag="new_3225621_3225771_c" /HighExp="G180, C30, G135, LBGexp, G150, Oxctl, HPh, Cold, BMM, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1201" promotor_-35 complement(2876762..2876766) /Source="Nicolas_upshift_promotors" /id="U2445" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.921078921078921" /psig=1 /xcortree=2503 /SigmaFactorBS="taaacctgattttttataaaaaagttttCTTTGcggaaataa gacatgTGTGATATAATTTTAAATTGcgtataaacagatatttaatttaacttaggag t" /listShort="yugI, S1200, S1198, yugJ" /listLong="yugK, S1196, pgi, yugM" /label="promotor_-35" promotor_-35 2876789..2876795 /Source="Nicolas_upshift_promotors" /id="U2446" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.662337662337662" /psig="0.662337662337662" /xcortree=1396 /SigmaFactorBS="tcacacatgtcttatttccgcaaagaaaacttttttataaaa aatcaGGTTTATgcacagcaaaaaggGGGTAAACTGAAAATACCAaaggctttctagt a" /listShort="S1202" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2876802..2877786 /Source="Nicolas_S_feature" /locus_tag="new_3225687_3226671" /HighExp="LoTm, C30, Salt, S7, S5, S8, Sw, S3, C90, S6" /AntisenseName="yugH" /AntisenseCor="-0.45629591209076698" /AntisenseRegPval="-14.5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.662" /TUlongSig="NA" /TUlongPSig="NA" /label="S1202" upshifts 2876802 /Source="Nicolas_upshifts" /id="U2446" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.662337662337662" /psig="0.662337662337662" /xcortree=1396 /SigmaFactorBS="tcacacatgtcttatttccgcaaagaaaacttttttataaaa aatcaGGTTTATgcacagcaaaaaggGGGTAAACTGAAAATACCAaaggctttctagt a" /listShort="S1202" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2876810..2876828 /Source="Nicolas_upshift_promotors" /id="U2446" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.662337662337662" /psig="0.662337662337662" /xcortree=1396 /SigmaFactorBS="tcacacatgtcttatttccgcaaagaaaacttttttataaaa aatcaGGTTTATgcacagcaaaaaggGGGTAAACTGAAAATACCAaaggctttctagt a" /listShort="S1202" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2876887..2878047) /gene="yugH" /locus_tag="BSU_31400" /old_locus_tag="BSU31400" /EC_number="2.6.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12670965; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aspartate aminotransferase" /protein_id="NP_391018.2" /db_xref="EnsemblGenomes-Gn:BSU31400" /db_xref="EnsemblGenomes-Tr:CAB15129" /db_xref="GOA:Q795M6" /db_xref="InterPro:IPR004838" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG12362" /db_xref="UniProtKB/Swiss-Prot:Q795M6" /translation="MTSYLSDYVQQIKPSGIRKFFDLAATMEGVISLGVGEPDFVTAW NVREASILSLEQGYTSYTANAGLYSLREEISRYLSNRFDLSYSPDNELIVTVGASQAL DIAIRAIVNPGEEVIIPEPCFVAYDALVSLAGGIPVHVHTTADKGFKATAADFEAAVT EKTKAILICSPSNPTGSVYSKEELNEIAEFAKKHDVIVLADEIYAELTYDEEFTSIAA LPGMKERTVVISGFSKAFAMTGWRLGFAAAPSLLRDAMLKIHQYAMMCAPAMAQFAAL EGLKNGMEDVEKMKKSYRRRRNLFVESLNEIGLSCHHPGGAFYAFPSIKSMGMSSEQF AEELLTQEKVAVVPGSVFGPSGEGYIRCSYATSIEQLQEALVRMKRFLHKTT*" /label="yugH CDS" gene complement(2876887..2878047) /gene="yugH" /locus_tag="BSU_31400" /old_locus_tag="BSU31400" /label="yugH gene" promotor_-35 2877939..2877945 /Source="Nicolas_upshift_promotors" /id="U2447" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.964035964035964" /psig="0.003996003996004" /xcortree=33 /SigmaFactorBS="tgcttgcttcgcggacattccatgcggtaacaaaatcaggct CGCCGACgcctaaagaaatgACGCCttccatcgttgccgccaaatcaaagaatttgcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2877957 /Source="Nicolas_upshifts" /id="U2447" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.964035964035964" /psig="0.003996003996004" /xcortree=33 /SigmaFactorBS="tgcttgcttcgcggacattccatgcggtaacaaaatcaggct CGCCGACgcctaaagaaatgACGCCttccatcgttgccgccaaatcaaagaatttgcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2877959..2877963 /Source="Nicolas_upshift_promotors" /id="U2447" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.964035964035964" /psig="0.003996003996004" /xcortree=33 /SigmaFactorBS="tgcttgcttcgcggacattccatgcggtaacaaaatcaggct CGCCGACgcctaaagaaatgACGCCttccatcgttgccgccaaatcaaagaatttgcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(2878048..2878548) /gene="yugG" /locus_tag="BSU_31410" /old_locus_tag="BSU31410" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (Lrp/AsnC family)" /protein_id="NP_391019.1" /db_xref="EnsemblGenomes-Gn:BSU31410" /db_xref="EnsemblGenomes-Tr:CAB15130" /db_xref="GOA:O05236" /db_xref="InterPro:IPR000485" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR019887" /db_xref="InterPro:IPR019888" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12361" /db_xref="UniProtKB/Swiss-Prot:O05236" /translation="MKLTEKETEILEILDENSRADLETIAKMAGIPVNEVKTIIDKLE KEKVIIDYSAMIDWRKVDGHEGVTAMIDVKVTPKRGVGFDEVAERIYRFQEVESVYLM SGVYDLSVVIRGNSMSDVARFVSDKLSTLDSVVSTTTHFILKKYKHDGKVFETGDDDK RIVVSP*" /label="yugG CDS" gene complement(2878048..2878548) /gene="yugG" /locus_tag="BSU_31410" /old_locus_tag="BSU31410" /label="yugG gene" promotor_-10 complement(2878578..2878597) /Source="Nicolas_upshift_promotors" /id="U2448" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.996003996003996" /psig=1 /xcortree=2242 /SigmaFactorBS="ccctgaaattgtcaattctagcggaagtttctcctcgttttt tcTTAGCATTcgtcaaaaaaCGTGATATAATGTCATGAGAtttcttgacattgcaaag g" /listShort="yugG, yugH, S1201, yugI" /listLong="S1200, S1198, yugJ, yugK, S1196, pgi, yugM" /label="promotor_-10" promotor_-35 2878584..2878590 /Source="Nicolas_upshift_promotors" /id="U2449" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=876 /SigmaFactorBS="tcatttgattcacacctttgcaatgtcaagaaatctcatGAC ATTAtatcacgttttttgACGAATGCTAAGaaaaaacgaggagaaacttccgctagaa t" /listShort="S1203, yugF" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2878599) /Source="Nicolas_upshifts" /id="U2448" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.996003996003996" /psig=1 /xcortree=2242 /SigmaFactorBS="ccctgaaattgtcaattctagcggaagtttctcctcgttttt tcTTAGCATTcgtcaaaaaaCGTGATATAATGTCATGAGAtttcttgacattgcaaag g" /listShort="yugG, yugH, S1201, yugI" /listLong="S1200, S1198, yugJ, yugK, S1196, pgi, yugM" /label="upshifts" promotor_-10 2878605..2878616 /Source="Nicolas_upshift_promotors" /id="U2449" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=876 /SigmaFactorBS="tcatttgattcacacctttgcaatgtcaagaaatctcatGAC ATTAtatcacgttttttgACGAATGCTAAGaaaaaacgaggagaaacttccgctagaa t" /listShort="S1203, yugF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2878605 /Source="Nicolas_upshifts" /id="U2449" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=876 /SigmaFactorBS="tcatttgattcacacctttgcaatgtcaagaaatctcatGAC ATTAtatcacgttttttgACGAATGCTAAGaaaaaacgaggagaaacttccgctagaa t" /listShort="S1203, yugF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2878608..2878615) /Source="Nicolas_upshift_promotors" /id="U2448" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.996003996003996" /psig=1 /xcortree=2242 /SigmaFactorBS="ccctgaaattgtcaattctagcggaagtttctcctcgttttt tcTTAGCATTcgtcaaaaaaCGTGATATAATGTCATGAGAtttcttgacattgcaaag g" /listShort="yugG, yugH, S1201, yugI" /listLong="S1200, S1198, yugJ, yugK, S1196, pgi, yugM" /label="promotor_-35" S_feature 2878617..2878695 /Source="Nicolas_S_feature" /locus_tag="new_3227502_3227580" /HighExp="S8, S5, S6, S7, S4, C30, Glucon, Pyr, nit, ferm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1203" CDS 2878696..2879517 /gene="yugF" /locus_tag="BSU_31420" /old_locus_tag="BSU31420" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_391020.1" /db_xref="EnsemblGenomes-Gn:BSU31420" /db_xref="EnsemblGenomes-Tr:CAB15131" /db_xref="GOA:O05235" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR000639" /db_xref="InterPro:IPR013595" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG12360" /db_xref="UniProtKB/Swiss-Prot:O05235" /translation="MEAVSPIRRFTVDGVNVYYEHYQNPGRQTLVCVHGFLSSAFSFR KVIPLLRDKYDIIALDLPPFGQSEKSRTFIYTYQNLAKLVIGILEHLQVKQAVLVGHS MGGQISLSAALQKPELFSKVVLLCSSGYLKRSHPTIIFGTHIPYFHLYIKRWLSKEGV MKNLLNVVHDKSLIDEEMIDGYGRPFQDEQIFKAMTRFIRHREGDLEPEQLKKMNKPA LLIWGEEDRIVPMEIGKRLHADLPNSVLYSLGQTGHLVPEERPELISEHIADFIK*" /label="yugF CDS" gene 2878696..2879517 /gene="yugF" /locus_tag="BSU_31420" /old_locus_tag="BSU31420" /label="yugF gene" downshifts 2879497 /Source="Nicolas_upshifts" /id="D1630" /incds=0 /nref=1 /ntot=12 /MaxReadThrough="1.0929" /MaxDrop="3.08755" /score="11.2614618" /energy="-6.6" /TU="NA" /idTUdmin="U2449" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(2879544) /Source="Nicolas_upshifts" /id="D1631" /incds=0 /nref=20 /ntot=156 /MaxReadThrough="2.22671" /MaxDrop="4.10906" /score="25.9859375" /energy="-6.6" /TU="NA" /idTUdmin="U2451" /TUdmin=7 /isTUend="TRUE" /label="downshifts" CDS complement(2879546..2879806) /gene="yugE" /locus_tag="BSU_31430" /old_locus_tag="BSU31430" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391021.2" /db_xref="EnsemblGenomes-Gn:BSU31430" /db_xref="EnsemblGenomes-Tr:CAB15132" /db_xref="InterPro:IPR015053" /db_xref="InterPro:IPR023162" /db_xref="SubtiList:BG12359" /db_xref="UniProtKB/Swiss-Prot:O05234" /translation="MEESHAVREMIKIIAKWDPFKYGEEFYETEAVDVVQAVYDENDP DLLAKSIQQIFETSFEQTLPIASCREVAGQLLFIKNSSSCTP*" /label="yugE CDS" gene complement(2879546..2879806) /gene="yugE" /locus_tag="BSU_31430" /old_locus_tag="BSU31430" /label="yugE gene" promotor_-35 2879796..2879799 /Source="Nicolas_upshift_promotors" /id="U2450" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.512487512487512" /psig="0.996003996003996" /xcortree=2691 /SigmaFactorBS="atgatcttaatcatttccctgaccgcatgaCTTTcttccata ttcatcACCGCTTATAATAAAATTTGcagttctatcttatcatagtgaagcttagaag a" /listShort="S1204, patB, kinB" /listLong="kapB" /label="promotor_-35" promotor_-10 2879814..2879833 /Source="Nicolas_upshift_promotors" /id="U2450" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.512487512487512" /psig="0.996003996003996" /xcortree=2691 /SigmaFactorBS="atgatcttaatcatttccctgaccgcatgaCTTTcttccata ttcatcACCGCTTATAATAAAATTTGcagttctatcttatcatagtgaagcttagaag a" /listShort="S1204, patB, kinB" /listLong="kapB" /label="promotor_-10" upshifts 2879826 /Source="Nicolas_upshifts" /id="U2450" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.512487512487512" /psig="0.996003996003996" /xcortree=2691 /SigmaFactorBS="atgatcttaatcatttccctgaccgcatgaCTTTcttccata ttcatcACCGCTTATAATAAAATTTGcagttctatcttatcatagtgaagcttagaag a" /listShort="S1204, patB, kinB" /listLong="kapB" /label="upshifts" S_feature 2879827..2879892 /Source="Nicolas_S_feature" /locus_tag="new_3228712_3228777" /HighExp="dia15, dia5, Lbexp, dia0, LBGtran, G180, Diami, H2O2, G150, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1204" promotor_-10 complement(2879832..2879851) /Source="Nicolas_upshift_promotors" /id="U2451" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=2500 /SigmaFactorBS="ttcattctgttaccccctcatgtatgttTATTCTTctaagct tcacTATGATAAGATAGAACTGCAaattttattataagcggtgatgaatatggaagaa a" /listShort="yugE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2879837) /Source="Nicolas_upshifts" /id="U2451" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=2500 /SigmaFactorBS="ttcattctgttaccccctcatgtatgttTATTCTTctaagct tcacTATGATAAGATAGAACTGCAaattttattataagcggtgatgaatatggaagaa a" /listShort="yugE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2879863..2879869) /Source="Nicolas_upshift_promotors" /id="U2451" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=2500 /SigmaFactorBS="ttcattctgttaccccctcatgtatgttTATTCTTctaagct tcacTATGATAAGATAGAACTGCAaattttattataagcggtgatgaatatggaagaa a" /listShort="yugE" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2879893..2881056 /gene="patB" /locus_tag="BSU_31440" /old_locus_tag="BSU31440" /EC_number="4.4.1.1" /EC_number="4.4.1.13" /EC_number="4.4.1.8" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15760717, 26337367, 28895253" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15760717, 26337367, 28895253; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous cystathionine / cystine beta-lyase /cysteine desulfhydrase" /protein_id="NP_391022.1" /db_xref="EnsemblGenomes-Gn:BSU31440" /db_xref="EnsemblGenomes-Tr:CAB15133" /db_xref="GOA:Q08432" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR027619" /db_xref="SubtiList:BG10744" /db_xref="UniProtKB/Swiss-Prot:Q08432" /translation="MNFDKREERLGTQSVKWDKTGELFGVTDALPMWVADMDFRAPEA ITEALKERLDHGIFGYTTPDQKTKDAVCGWMQNRHGWKVNPESITFSPGVVTALSMAV QAFTEPGDQVVVQPPVYTPFYHMVEKNGRHILHNPLLEKDGAYAIDFEDLETKLSDPS VTLFILCNPHNPSGRSWSREDLLKLGELCLEHGVTVVSDEIHSDLMLYGHKHTPFASL SDDFADISVTCAAPSKTFNIAGLQASAIIIPDRLKRAKFSASLQRNGLGGLNAFAVTA IEAAYSKGGPWLDELITYIEKNMNEAEAFLSTELPKVKMMKPDASYLIWLDFSAYGLS DAELQQRMLKKGKVILEPGTKYGPGGEGFMRLNAGCSLATLQDGLRRIKAALS*" /label="patB CDS" gene 2879893..2881056 /gene="patB" /locus_tag="BSU_31440" /old_locus_tag="BSU31440" /label="patB gene" promotor_-35 2881119..2881125 /Source="Nicolas_upshift_promotors" /id="U2452" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.852147852147852" /psig="0.999000999001" /xcortree=3054 /SigmaFactorBS="ttgtaaaggcgttcttaataaaggaattttatATTTTACttc taatatttAGTGTTATAATAGATTCATAttttatacgaaaggatttcacacgaatgga a" /listShort="kinB, kapB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2881137..2881156 /Source="Nicolas_upshift_promotors" /id="U2452" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.852147852147852" /psig="0.999000999001" /xcortree=3054 /SigmaFactorBS="ttgtaaaggcgttcttaataaaggaattttatATTTTACttc taatatttAGTGTTATAATAGATTCATAttttatacgaaaggatttcacacgaatgga a" /listShort="kinB, kapB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2881147 /Source="Nicolas_upshifts" /id="U2452" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.852147852147852" /psig="0.999000999001" /xcortree=3054 /SigmaFactorBS="ttgtaaaggcgttcttaataaaggaattttatATTTTACttc taatatttAGTGTTATAATAGATTCATAttttatacgaaaggatttcacacgaatgga a" /listShort="kinB, kapB" /GFF_Attribute="listLong" /label="upshifts" CDS 2881182..2882468 /gene="kinB" /locus_tag="BSU_31450" /old_locus_tag="BSU31450" /EC_number="2.7.13.3" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:9426145, 11069677, 15849754, 16850406, 26152584, 28583948" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9426145, 11069677, 15849754, 16850406, 26152584, 28583948; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="two-component sensor potassium-binding histidinekinase" /protein_id="NP_391023.2" /db_xref="EnsemblGenomes-Gn:BSU31450" /db_xref="EnsemblGenomes-Tr:CAB15134" /db_xref="GOA:Q08430" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG10745" /db_xref="UniProtKB/Swiss-Prot:Q08430" /translation="MEILKDYLLHICFILFPILLYQVFWLGKPAILVPKINSGLVTLF ACGASVLCIIFPIHEMDYIQYGLQMIPVIICLFYISTASGLTVAASVLCFELLFYEPS AMFVFTLLPFLIIIPILFQKKWPFMSKAKKLLLSLLISCVEIFLFFASSWILSALNIL NFQKSGIFVYEAAVSGLFRSSVLLLSIYIIESIAENIALRSQLIHSEKMTIVSELAAS VAHEVRNPLTVVRGFVQLLFNDETLQNKSSADYKKLVLSELDRAQGIITNYLDMAKQQ LYEKEVFDLSALIKETSSLMVSYANYKSVTVEAETEPDLLIYGDATKLKQAVINLMKN SIEAVPHGKGMIHISAKRNGHTIMINITDNGVGMTDHQMQKLGEPYYSLKTNGTGLGL TVTFSIIEHHHGTISFNSSFQKGTTVTIKLPADLPH*" /label="kinB CDS" gene 2881182..2882468 /gene="kinB" /locus_tag="BSU_31450" /old_locus_tag="BSU31450" /label="kinB gene" S_feature complement(2882184..2882926) /Source="Nicolas_S_feature" /locus_tag="new_3231069_3231811_c" /HighExp="BT, S8, B36, S6, S7, S5, S3, S4, Cold, Pyr" /AntisenseName="kapB" /AntisenseCor="-0.71681066342113797" /AntisenseRegPval="-43" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigK" /TUshortPSig="0.709, 0.985" /TUlongSig="NA" /TUlongPSig="NA" /label="S1205" promotor_-35 2882463..2882470 /Source="Nicolas_upshift_promotors" /id="U2453" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.679320679320679" /psig="0.986013986013986" /xcortree=2010 /SigmaFactorBS="gcactacggtgaccattaagcttcccgctgatcttcctCACT AGCAaatcgattggaacTTTAATAGAATAAATGCGAGgtgatgacagatgagcacgtt t" /listShort="kapB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2882484..2882503 /Source="Nicolas_upshift_promotors" /id="U2453" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.679320679320679" /psig="0.986013986013986" /xcortree=2010 /SigmaFactorBS="gcactacggtgaccattaagcttcccgctgatcttcctCACT AGCAaatcgattggaacTTTAATAGAATAAATGCGAGgtgatgacagatgagcacgtt t" /listShort="kapB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2882485 /Source="Nicolas_upshifts" /id="U2453" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.679320679320679" /psig="0.986013986013986" /xcortree=2010 /SigmaFactorBS="gcactacggtgaccattaagcttcccgctgatcttcctCACT AGCAaatcgattggaacTTTAATAGAATAAATGCGAGgtgatgacagatgagcacgtt t" /listShort="kapB" /GFF_Attribute="listLong" /label="upshifts" CDS 2882514..2882900 /gene="kapB" /locus_tag="BSU_31460" /old_locus_tag="BSU31460" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:9426145, 23335417" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9426145, 23335417; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor required for KinB signal transduction andactivation of the phosphorelay to sporulation" /protein_id="NP_391024.1" /db_xref="EnsemblGenomes-Gn:BSU31460" /db_xref="EnsemblGenomes-Tr:CAB15135" /db_xref="GOA:Q08429" /db_xref="InterPro:IPR014916" /db_xref="SubtiList:BG10746" /db_xref="UniProtKB/Swiss-Prot:Q08429" /translation="MSTFETGSIVKGFYKTGVYIGEITACRPQHYLVKVKAVLTHPAQ GDLHHPKQADVPFFHERKALAYGEQTNIPHHMVKPYDGEVPDYTESLREATAQMRAKL NEDGSEWAKRSLHNLDILEKEYFNRP*" /label="kapB CDS" gene 2882514..2882900 /gene="kapB" /locus_tag="BSU_31460" /old_locus_tag="BSU31460" /label="kapB gene" downshifts 2882882 /Source="Nicolas_upshifts" /id="D1632" /incds=0 /nref=209 /ntot=249 /MaxReadThrough="1.62013" /MaxDrop="5.57132" /score="1.97959632" /energy="-9.2" /TU="NA" /idTUdmin="U2452" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2882927..2883544) /gene="kapD" /locus_tag="BSU_31470" /old_locus_tag="BSU31470" /EC_number="3.1.-.-" /function="16.3: Control" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 27188294; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative exoribonuclease (3'-5')" /protein_id="NP_391025.1" /db_xref="EnsemblGenomes-Gn:BSU31470" /db_xref="EnsemblGenomes-Tr:CAB15136" /db_xref="GOA:O05231" /db_xref="InterPro:IPR012337" /db_xref="InterPro:IPR013520" /db_xref="InterPro:IPR036397" /db_xref="SubtiList:BG12358" /db_xref="UniProtKB/Swiss-Prot:O05231" /translation="MTTNSLLIIDFEFTMPDGKYSPQNFFPEIIEAGIVKSIDDEVVE TFSSYVRPKKFPKLTKRCKSFLKITQKQVDEGMRFEDFIRKLNELDPEKNSTIITWGN MDMKVLKQNCMFNHIPFPFKGEMRDLSLEYKNFFGDRTLTGLWKAAEEYGDSGTGTHH KALDDALTAYKLFKLVEQDKQYLEKPKPPTIGERIDLTELLKRAT*" /label="kapD CDS" gene complement(2882927..2883544) /gene="kapD" /locus_tag="BSU_31470" /old_locus_tag="BSU31470" /label="kapD gene" promotor_-10 complement(2883579..2883597) /Source="Nicolas_upshift_promotors" /id="U2454" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.709290709290709" /psig="0.709290709290709" /xcortree=1399 /SigmaFactorBS="cgaagcggctgggaaaattcattatttttagaaaatgaaGAA ATGtcgagaaggggaatTGATATACTATAAAGATAGcattttctgatcggaggaaagg c" /listShort="kapD, S1205" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2883596) /Source="Nicolas_upshifts" /id="U2454" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.709290709290709" /psig="0.709290709290709" /xcortree=1399 /SigmaFactorBS="cgaagcggctgggaaaattcattatttttagaaaatgaaGAA ATGtcgagaaggggaatTGATATACTATAAAGATAGcattttctgatcggaggaaagg c" /listShort="kapD, S1205" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2883598..2885686) /Source="Nicolas_S_feature" /locus_tag="new_3232483_3234571_c" /HighExp="S8, BT, B36, S7, S6, Pyr, C30, B60, S5, G135" /AntisenseName="yuxJ" /AntisenseCor="-0.168930816447634" /AntisenseRegPval="-2.2999999999999998" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.985" /TUlongSig="NA" /TUlongPSig="NA" /label="S1206" promotor_-35 complement(2883612..2883617) /Source="Nicolas_upshift_promotors" /id="U2454" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.709290709290709" /psig="0.709290709290709" /xcortree=1399 /SigmaFactorBS="cgaagcggctgggaaaattcattatttttagaaaatgaaGAA ATGtcgagaaggggaatTGATATACTATAAAGATAGcattttctgatcggaggaaagg c" /listShort="kapD, S1205" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2883660..2883663 /Source="Nicolas_upshift_promotors" /id="U2455" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.561438561438561" /psig=1 /xcortree=1539 /SigmaFactorBS="aaaataatgaattttcccagccgcttcgtttCTTTtaaattg tgaatcgTTTCTTTATAATTAGTAAGGaacccgaaataataagaaggtgatgttattt c" /listShort="yuxJ" /listLong="pbpD, yuxK" /label="promotor_-35" promotor_-10 2883678..2883697 /Source="Nicolas_upshift_promotors" /id="U2455" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.561438561438561" /psig=1 /xcortree=1539 /SigmaFactorBS="aaaataatgaattttcccagccgcttcgtttCTTTtaaattg tgaatcgTTTCTTTATAATTAGTAAGGaacccgaaataataagaaggtgatgttattt c" /listShort="yuxJ" /listLong="pbpD, yuxK" /label="promotor_-10" upshifts 2883689 /Source="Nicolas_upshifts" /id="U2455" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.561438561438561" /psig=1 /xcortree=1539 /SigmaFactorBS="aaaataatgaattttcccagccgcttcgtttCTTTtaaattg tgaatcgTTTCTTTATAATTAGTAAGGaacccgaaataataagaaggtgatgttattt c" /listShort="yuxJ" /listLong="pbpD, yuxK" /label="upshifts" CDS 2883755..2884933 /gene="yuxJ" /locus_tag="BSU_31480" /old_locus_tag="BSU31480" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 20011599; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative exporter induced in acid stress" /protein_id="NP_391026.2" /db_xref="EnsemblGenomes-Gn:BSU31480" /db_xref="EnsemblGenomes-Tr:CAB15137" /db_xref="GOA:P40760" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10976" /db_xref="UniProtKB/Swiss-Prot:P40760" /translation="MWLANFFVSASTTMIVPFLSLYIETLSSFSNGFVQRWSGYVFGI TFLMAFLVSPFWGRFGDKRGYKKILMATGTGIALSIFFMGFVTSVYQLFFLRMAMGLV TGFIPTSLAMISAQTPKSSAGKTLGTLQMGQVSGSLFGPLLGGMLADRFGFTYTFFIT SFVIFSSVLLVLFGVKEKHLAEKTAKRTSYSRKEVLSYIFHHPALWVMMLLTMLIQTG NFSIQPLLALYVNELHGPVNLAFFSGMAFSATGLGSLLLARKWGDLGDRYGHRRILIG LLLAASFFFIPQALASSLSVLLVFRFLFGMAMGGLLPCITAAIRVQAPGSIQGEVLGY NVSFRFLGNVLGPLLGGIISSHFTISATFYVTAFLFFAGACMLWIMQKLRKDSYAKAS *" /label="yuxJ CDS" gene 2883755..2884933 /gene="yuxJ" /locus_tag="BSU_31480" /old_locus_tag="BSU31480" /label="yuxJ gene" promotor_-35 2884971..2884977 /Source="Nicolas_upshift_promotors" /id="U2456" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig=1 /xcortree=2246 /SigmaFactorBS="ttccgagaaaaaactaaggaatcttctaaatttaaccTTCTC GTaatctcaaaagAATGGTACGATATGGCTAGAatttaggagaaaagagagtgaccat g" /listShort="pbpD, yuxK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2884989..2885008 /Source="Nicolas_upshift_promotors" /id="U2456" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig=1 /xcortree=2246 /SigmaFactorBS="ttccgagaaaaaactaaggaatcttctaaatttaaccTTCTC GTaatctcaaaagAATGGTACGATATGGCTAGAatttaggagaaaagagagtgaccat g" /listShort="pbpD, yuxK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2884994 /Source="Nicolas_upshifts" /id="U2456" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig=1 /xcortree=2246 /SigmaFactorBS="ttccgagaaaaaactaaggaatcttctaaatttaaccTTCTC GTaatctcaaaagAATGGTACGATATGGCTAGAatttaggagaaaagagagtgaccat g" /listShort="pbpD, yuxK" /GFF_Attribute="listLong" /label="upshifts" CDS 2885026..2886900 /gene="pbpD" /locus_tag="BSU_31490" /old_locus_tag="BSU31490" /EC_number="2.-.-.-" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7961491, 9274030; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="penicillin-binding protein 4" /protein_id="NP_391027.2" /db_xref="EnsemblGenomes-Gn:BSU31490" /db_xref="EnsemblGenomes-Tr:CAB15138" /db_xref="GOA:P40750" /db_xref="InterPro:IPR001264" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR023346" /db_xref="InterPro:IPR036950" /db_xref="SubtiList:BG10977" /db_xref="UniProtKB/Swiss-Prot:P40750" /translation="MTMLRKIIGWILLLCIIPLFAFTVIASGKEVKQMKSLDQVLDKN IDLKDISLVQNSYMYDRDGSLVSEIVSDHENRVLVPFNKIPEEVKQIFLTSEDRHFYE HKGFDFMGMVRATASNVKDKKIDQGASTITQQLSRNLYLSHERSFSRKLTELAYSYQL EKKYTKNEILEAYLNTIYFNNGVYGVGSAAQFYFSKPLKSLTVGEMAFICAIPNNPTL YDPLKHFDYTKSRQERLLKGLKDAGVITDKELKKAVKQKIKLDVEKREDKYPDYVSYV NDEFTQLVSESEGFDKRLQKASGKQKEKIENELSARVSTLMKDGVKIYTALDPYMQNQ VVAQMNSKLPYADVQGGAAVINHQTHQIIALSGGKNYQKYDFNRAYQAYRQPGSSIKP LLDYGPYIEQTGATTSSTIDASKFCSKDYCPQNYNNRTYGTVTLDTAFKNSYNTPAIR MLDRVGIQKAFSYIEPYHFAKLVDSDYLLPAALGGFTNGMTPLEMTKAYTTFGNSGSY TPSHAITKVTDLKGKTLYKWNDKATQIFSVRTNMQLKKLMSSVVKSGTGKKAYFNAPY IGGKTGTSNDYHDMWFVGLTDTYTMGVWVGKDTPTSVEYLHSISPQLSIWKGTLQAAY *" /label="pbpD CDS" gene 2885026..2886900 /gene="pbpD" /locus_tag="BSU_31490" /old_locus_tag="BSU31490" /label="pbpD gene" promotor_-10 complement(2885666..2885685) /Source="Nicolas_upshift_promotors" /id="U2457" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1344 /SigmaFactorBS="cttttagccctttaagtaaacgttcttgacggcttttcGTGT AGTCAAaatgcttgagaggATCATATAATGTAGGGTTATtaggtatagcacagataaa a" /listShort="S1206, kapD, S1205" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2885686) /Source="Nicolas_upshifts" /id="U2457" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1344 /SigmaFactorBS="cttttagccctttaagtaaacgttcttgacggcttttcGTGT AGTCAAaatgcttgagaggATCATATAATGTAGGGTTATtaggtatagcacagataaa a" /listShort="S1206, kapD, S1205" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2885699..2885708) /Source="Nicolas_upshift_promotors" /id="U2457" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.985014985014985" /psig="0.985014985014985" /xcortree=1344 /SigmaFactorBS="cttttagccctttaagtaaacgttcttgacggcttttcGTGT AGTCAAaatgcttgagaggATCATATAATGTAGGGTTATtaggtatagcacagataaa a" /listShort="S1206, kapD, S1205" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2886921..2887334 /gene="yuxK" /locus_tag="BSU_31500" /old_locus_tag="BSU31500" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 26335199; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative thiol-disulfide oxidoreductase" /protein_id="NP_391028.1" /db_xref="EnsemblGenomes-Gn:BSU31500" /db_xref="EnsemblGenomes-Tr:CAB15139" /db_xref="InterPro:IPR007263" /db_xref="SubtiList:BG10978" /db_xref="UniProtKB/Swiss-Prot:P40761" /translation="MTSEQIPNRVLLFDGVCNLCNGAVQFIIKRDPDGLISFTSLQSE TGQSLLKKSGLPTDRFDSFVFIEDGQVYTKSTAAIKVFRHLRGPWRLFVLFFAVPKPV RDMVYSFIAKNRYKWFGKKNECMLPSPSIKKRFLP*" /label="yuxK CDS" gene 2886921..2887334 /gene="yuxK" /locus_tag="BSU_31500" /old_locus_tag="BSU31500" /label="yuxK gene" downshifts 2887326 /Source="Nicolas_upshifts" /id="D1633" /incds=0 /nref=1 /ntot=254 /MaxReadThrough="5.05064" /MaxDrop="3.14634" /score="-3.58105315" /energy="-11.5" /TU="U2456" /idTUdmin="U2456" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(2887537..2888094) /gene="yufK" /locus_tag="BSU_31510" /old_locus_tag="BSU31510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_391029.2" /db_xref="EnsemblGenomes-Gn:BSU31510" /db_xref="EnsemblGenomes-Tr:CAB15140" /db_xref="GOA:O05249" /db_xref="InterPro:IPR035289" /db_xref="SubtiList:BG12346" /db_xref="UniProtKB/Swiss-Prot:O05249" /translation="MKNTYLTGYFPLIAILLFSSSLSISTSLYALKMLSSFGMYDGML DYFSEKGIRLALFAAFALLYFMVLSALKLIANTVTELSLLFFANDPEGNNLKKLRMGS MIYLGGGILSFVLLQNVIWIVIWFAVVTLAYFVFTVYRIYSTLSLMSLVGFILLELLF WFTFVIGILFIFIKLYNSIMASLPV*" /label="yufK CDS" gene complement(2887537..2888094) /gene="yufK" /locus_tag="BSU_31510" /old_locus_tag="BSU31510" /label="yufK gene" misc_feature 2887558..2887577 /Source="Nicolas_upshift_promotors" /id="U2458" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.845154845154845" /psig="0.878121878121878" /xcortree=2785 /SigmaFactorBS="tctgaccaccaaacgctgaaatggctagcttacacaggtaag ctagccatTATGCTATTATAAAGCTTGAtaaatatgaacagaataccgataacaaagg t" /listShort="S1207" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2887568 /Source="Nicolas_upshifts" /id="U2458" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.845154845154845" /psig="0.878121878121878" /xcortree=2785 /SigmaFactorBS="tctgaccaccaaacgctgaaatggctagcttacacaggtaag ctagccatTATGCTATTATAAAGCTTGAtaaatatgaacagaataccgataacaaagg t" /listShort="S1207" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(2887578) /Source="Nicolas_upshifts" /id="D1634" /incds=0 /nref=10 /ntot=201 /MaxReadThrough="3.90201" /MaxDrop="3.94501" /score="-6.00543052" /energy="-18.5" /TU="U2459" /idTUdmin="U2459" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" S_feature 2887590..2888271 /Source="Nicolas_S_feature" /locus_tag="new_3236475_3237156" /HighExp="Diami, Cold, LBGstat, H2O2, Lbtran, Gly, M0t90, GM 10, GM-0.2, dia15" /AntisenseName="yufK" /AntisenseCor="0.32488342936044701" /AntisenseRegPval="-7.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.878" /TUlongSig="NA" /TUlongPSig="NA" /label="S1207" promotor_-10 complement(2888120..2888139) /Source="Nicolas_upshift_promotors" /id="U2459" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=2604 /SigmaFactorBS="gtaaaaaggagaaaaaatggaataatttaTCTTGtcaatgtg ttttaagTCCTCCATAATAAATGAGGTagattatagaaagggacttttttatatgaaa a" /listShort="yufK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2888128) /Source="Nicolas_upshifts" /id="U2459" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=2604 /SigmaFactorBS="gtaaaaaggagaaaaaatggaataatttaTCTTGtcaatgtg ttttaagTCCTCCATAATAAATGAGGTagattatagaaagggacttttttatatgaaa a" /listShort="yufK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2888155..2888159) /Source="Nicolas_upshift_promotors" /id="U2459" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=2604 /SigmaFactorBS="gtaaaaaggagaaaaaatggaataatttaTCTTGtcaatgtg ttttaagTCCTCCATAATAAATGAGGTagattatagaaagggacttttttatatgaaa a" /listShort="yufK" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2888272..2889873 /gene="maeL" /locus_tag="BSU_31520" /old_locus_tag="BSU31520" /EC_number="2.7.13.3" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 12949159, 12949160, 22001508" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 12949159, 12949160, 22001508; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [MaeM]" /protein_id="NP_391030.1" /db_xref="EnsemblGenomes-Gn:BSU31520" /db_xref="EnsemblGenomes-Tr:CAB15141" /db_xref="GOA:O05250" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR013767" /db_xref="InterPro:IPR016120" /db_xref="InterPro:IPR029151" /db_xref="InterPro:IPR033463" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12347" /db_xref="UniProtKB/Swiss-Prot:O05250" /translation="MKKTLKLQTRLTIFVCIVVLIALLITFFTVGAQTTKRIRDQEKA TALQTAEMVAEAPMTAAALESGKKQKELQSYTKRVQKITGTEFVVVMDMNGIRKTHPD PSKIGKKFRGGDESEVLKGHVHISTASGTLGKSQRAFVPVYAENGKQVGAVAVGITVN EIDEVISHSLRPLYFIICVSIFVGVIGAVIVARTVKNIMYGLEPYEIATLLEERSAML ESTKEGILAVDEHGKIKLANAEAKRLFVKMGINTNPIDQDVDDILPKSRLKKVIETKK PLQDRDVRINGLELVFNEVPIQLKGQTVGAIATFRDKTEVKHLAEQLSGVKMYANALR AQSHEFMNKLHVILGLVQLKEYDDLGDYIKDIAIQQKSETSEIINDVKSSVLAGFLLG KQSFIREQGANLDIECNGVIPNAADPSVIHELITIIGNLINNGLDAVADMPKKQITMS MRFHNSILDIEITDTGAGMSEEDQAKVFEQGYSTKGKNRGFGLYFTQQSIENLKGQMI LTSEKNEGTTFSIRIPYEPKEENHD*" /label="maeL CDS" gene 2888272..2889873 /gene="maeL" /locus_tag="BSU_31520" /old_locus_tag="BSU31520" /label="maeL gene" CDS 2889866..2890573 /gene="maeM" /locus_tag="BSU_31530" /old_locus_tag="BSU31530" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 12949159, 12949160, 22001508" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 12949159, 12949160, 22001508; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator for malate metabolism [MaeL]" /protein_id="NP_391031.1" /db_xref="EnsemblGenomes-Gn:BSU31530" /db_xref="EnsemblGenomes-Tr:CAB15142" /db_xref="GOA:O05251" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR024187" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12348" /db_xref="UniProtKB/Swiss-Prot:O05251" /translation="MINVLIVEDDPMVGELNKRYLSQIDGFQLKGIASSFQSALHILG EHHIDLILLDIYMPGKNGLELLTELRAQNEAVDVIVISAASELDVIKKTLRYGAVDYL IKPFEFERFQTALSDYRRKQKVYSTHRNMSQKELDAELFQKKEATEKVQLPKGLTKST LKLIWSSIQSFENESFTTEDLAKHTEISQVSIRKYLKFLEDIQVLNVEMAYGTIGRPV FQYNVNNSNINGIKQYL*" /label="maeM CDS" gene 2889866..2890573 /gene="maeM" /locus_tag="BSU_31530" /old_locus_tag="BSU31530" /label="maeM gene" downshifts 2890558 /Source="Nicolas_upshifts" /id="D1635" /incds=0 /nref=173 /ntot=245 /MaxReadThrough="1.97489" /MaxDrop="5.86018" /score="19.9464971" /energy="-15.3" /TU="NA" /idTUdmin="U2458" /TUdmin=2660 /isTUend="FALSE" /label="downshifts" promotor_-35 2890737..2890744 /Source="Nicolas_upshift_promotors" /id="U2460" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.999000999001" /xcortree=2875 /SigmaFactorBS="aattctaaaaatagataatttttaaaaaattatgcgaaattc TATTTATTtcttattagttaaaTGATAAATTATGATTGGTTAgttgatcccgaaaaac t" /listShort="S1208, yufN, yufO, yufP, yufQ, S1209, maeN" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2890755..2891044 /Source="Nicolas_S_feature" /locus_tag="new_3239640_3239929" /HighExp="T1.30H, T1.0H, T2.30H, T2.0H, M9-stat, S1, T3.0H, T3.30H, T0.30H, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1208" upshifts 2890755 /Source="Nicolas_upshifts" /id="U2460" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.999000999001" /xcortree=2875 /SigmaFactorBS="aattctaaaaatagataatttttaaaaaattatgcgaaattc TATTTATTtcttattagttaaaTGATAAATTATGATTGGTTAgttgatcccgaaaaac t" /listShort="S1208, yufN, yufO, yufP, yufQ, S1209, maeN" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2890759..2890778 /Source="Nicolas_upshift_promotors" /id="U2460" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.936063936063936" /psig="0.999000999001" /xcortree=2875 /SigmaFactorBS="aattctaaaaatagataatttttaaaaaattatgcgaaattc TATTTATTtcttattagttaaaTGATAAATTATGATTGGTTAgttgatcccgaaaaac t" /listShort="S1208, yufN, yufO, yufP, yufQ, S1209, maeN" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2891045..2892124 /gene="nupN" /locus_tag="BSU_31540" /old_locus_tag="BSU31540" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:21926227, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21926227, 22720735; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="lipoprotein involved in guanosine transport" /protein_id="NP_391032.2" /db_xref="EnsemblGenomes-Gn:BSU31540" /db_xref="EnsemblGenomes-Tr:CAB15143" /db_xref="GOA:O05252" /db_xref="InterPro:IPR003760" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG12349" /db_xref="UniProtKB/Swiss-Prot:O05252" /translation="MNKRKIGLAMSLVIAAGTILGACGNSEKSSGSGEGKNKFSVAMV TDVGGVDDKSFNQSAWEGIQAFGKENGLKKGKNGYDYLQSKSDADYTTNLNKLARENF DLIYGVGYLMEDSISEIADQRKNTNFAIIDAVVDKDNVASITFKEQEGSFLVGVAAAL SSKSGKIGFVGGMESELIKKFEVGFRAGVQAVNPKAVVEVKYAGGFDKADVGKATAES MYKSGVDVIYHSAGATGTGVFTEAKNLKKEDPKRDVWVIGVDKDQYAEGQVEGTDDNV TLTSMVKKVDTVVEDVTKKASDGKFPGGETLTYGLDQDGVGISPSKQNLSDDVIKAVD KWKKKIIDGLEIPATEKELKTFKAE*" /label="nupN CDS" gene 2891045..2892124 /gene="nupN" /locus_tag="BSU_31540" /old_locus_tag="BSU31540" /label="nupN gene" CDS 2892200..2893732 /gene="nupO" /locus_tag="BSU_31550" /old_locus_tag="BSU31550" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:21926227, 25875741" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21926227, 25875741; Product type t: transporter" /codon_start=1 /transl_table=11 /product="guanosine ABC transporter (ATP-binding protein)" /protein_id="NP_391033.1" /db_xref="EnsemblGenomes-Gn:BSU31550" /db_xref="EnsemblGenomes-Tr:CAB15144" /db_xref="GOA:O05253" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12350" /db_xref="UniProtKB/Swiss-Prot:O05253" /translation="MEYVIEMLNIRKAFPGIVANDNINLQVKKGEIHALLGENGAGKS TLMNVLFGLYQPERGEIRVRGEKVHINSPNKANDLGIGMVHQHFMLVDTFTVAENIIL GKEPKKFGRIDRKRAGQEVQDISDRYGLQIHPEAKAADISVGMQQRAEILKTLYRGAD ILIFDEPTAVLTPHEIKELMQIMKNLVKEGKSIILITHKLKEIMEICDRVTVIRKGKG IKTLDVRDTNQDELASLMVGREVSFKTEKRAAQPGAEVLAIDGITVKDTRGIETVRDL SLSVKAGEIVGIAGVDGNGQSELIEAVTGLRKTDSGTITLNGKQIQNLTPRKITESGI GHIPQDRHKHGLVLDFPIGENILLQSYYKKPYSALGVLHKGEMYKKARSLITEYDVRT PDEYTHARALSGGNQQKAIIGREIDRNPDLLIAAQPTRGLDVGAIEFVHKKLIEQRDA GKAVLLLSFELEEIMNLSDRIAVIFEGRIIASVNPQETTEQELGLLMAGSTQKEAGKA NG*" /label="nupO CDS" gene 2892200..2893732 /gene="nupO" /locus_tag="BSU_31550" /old_locus_tag="BSU31550" /label="nupO gene" CDS 2893725..2894771 /gene="nupP" /locus_tag="BSU_31560" /old_locus_tag="BSU31560" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 21926227" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 21926227; Product type t: transporter" /codon_start=1 /transl_table=11 /product="permease of ABC guanosine transporter" /protein_id="NP_391034.1" /db_xref="EnsemblGenomes-Gn:BSU31560" /db_xref="EnsemblGenomes-Tr:CAB15145" /db_xref="GOA:O05254" /db_xref="InterPro:IPR001851" /db_xref="InterPro:IPR002229" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG12351" /db_xref="UniProtKB/Swiss-Prot:O05254" /translation="MVKRLSHLLVPLIAIILGLAAGALIMLVSGYSVASGYSALWNGI FGEIYYVGETIRQITPYILSGLAVAFAFRTGLFNIGVEGQLLVGWTAAVWVGTAFDGP AYIHLPLALITAAAAGGLWGFIPGILKARFYVHEVIVTIMMNYIALHMTNYIISNVLT DHQDKTGKIHESASLRSPFLEQITDYSRLHLGIIVALLAAVIMWFIINKSTKGFELRA VGFNQHASQYAGMSVRKNIMTSMLISGAFAGLAGAMEGLGTFEYAAVKGAFTGVGFDG IAVALLGGNTAVGVVLAACLLGGLKIGALNMPIESGVPSEVVDIVIAIIILFVASSYA IRFVMGKLKKKGAN*" /label="nupP CDS" gene 2893725..2894771 /gene="nupP" /locus_tag="BSU_31560" /old_locus_tag="BSU31560" /label="nupP gene" CDS 2894772..2895731 /gene="nupQ" /locus_tag="BSU_31570" /old_locus_tag="BSU31570" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 21926227" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 21926227; Product type t: transporter" /codon_start=1 /transl_table=11 /product="permease of ABC guanosine transporter" /protein_id="NP_391035.1" /db_xref="EnsemblGenomes-Gn:BSU31570" /db_xref="EnsemblGenomes-Tr:CAB15146" /db_xref="GOA:O05255" /db_xref="InterPro:IPR001851" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG12352" /db_xref="UniProtKB/Swiss-Prot:O05255" /translation="MDIVQILSIIVPATLVYAAPLILTALGGVFSERSGVVNIGLEGL MIIGAFTSVLFNLFFGQELGAAAPWLSLLAAMAAGALFSLIHAAAAISFRADQTVSGV AINMLALGATLFIVKLIYGKAQTDKIPEPFYKTKIPGLGDIPVLGKIFFSDVYYTSIL AIALAFISWFILFKTPFGLRIRSVGEHPMAADTMGINVYKMRYIGVMISGLFGGLGGG VYASTIALDFTHSTISGQGFIALAALVFGKWHPIGALGAALFFGFAQSLSIIGSLLPL FKDIPNVYMLMAPYILTILALTGFIGRADAPKANGVPYIKGKR*" /label="nupQ CDS" gene 2894772..2895731 /gene="nupQ" /locus_tag="BSU_31570" /old_locus_tag="BSU31570" /label="nupQ gene" S_feature 2895732..2895853 /Source="Nicolas_S_feature" /locus_tag="new_3244617_3244738" /HighExp="S1, BT, M9-stat, T1.30H, S2, LoTm, T1.0H, T2.30H, T2.0H, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1209" promotor_-35 2895826..2895829 /Source="Nicolas_upshift_promotors" /id="U2461" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.944055944055944" /psig="0.996003996003996" /xcortree=1755 /SigmaFactorBS="taattgtttattagttttttaacttaaaaaaATATgaagtgt taacgctTTCTTGTAGACTGTAACAAAcaatacatgggggtgtatgacatgggagcaa t" /listShort="maeN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2895844..2895863 /Source="Nicolas_upshift_promotors" /id="U2461" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.944055944055944" /psig="0.996003996003996" /xcortree=1755 /SigmaFactorBS="taattgtttattagttttttaacttaaaaaaATATgaagtgt taacgctTTCTTGTAGACTGTAACAAAcaatacatgggggtgtatgacatgggagcaa t" /listShort="maeN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2895855 /Source="Nicolas_upshifts" /id="U2461" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.944055944055944" /psig="0.996003996003996" /xcortree=1755 /SigmaFactorBS="taattgtttattagttttttaacttaaaaaaATATgaagtgt taacgctTTCTTGTAGACTGTAACAAAcaatacatgggggtgtatgacatgggagcaa t" /listShort="maeN" /GFF_Attribute="listLong" /label="upshifts" CDS 2895885..2897231 /gene="maeN" /locus_tag="BSU_31580" /old_locus_tag="BSU31580" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11004162, 12949159, 15849754, 16850406, 17183219, 19087206, 19114526, 20011599" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11004162, 12949159, 15849754, 16850406, 17183219, 19087206, 19114526, 20011599; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Na+/malate symporter" /protein_id="NP_391036.1" /db_xref="EnsemblGenomes-Gn:BSU31580" /db_xref="EnsemblGenomes-Tr:CAB15147" /db_xref="GOA:O05256" /db_xref="InterPro:IPR004679" /db_xref="InterPro:IPR018025" /db_xref="SubtiList:BG12353" /db_xref="UniProtKB/Swiss-Prot:O05256" /translation="MGAIPKTGTISPEQKDSQEKNLFQKIWSWEIGVIPLPLYTVLAV IIILAAYYNELPANMLGGFAIIMILGVFLGDIGQRIPILKDIGGPAILSLFVPSFLVF YNVLNSTSLDAVTNLMKTSNFLYFYIACLVVGSILGMNRIVLIQGFIRMFVPLVAGTI AAVAAGILVGFIFGYSAYDSFFFVVVPIIAGGIGEGILPLSIAYSQILGSSADVFVSQ LVPAAIIGNVFAIICAALMKKLGDKRPDLNGNGRLVKSKKANEIFNQKEAEAKIDFKL MGAGVLLACTFFIFGGLLEKFIFIPGAILMIISAAAVKYANILPKKMEEGAYQLYKFI SSSFTWPLMVGLGILFIPLDDVASVISIPFVIICISVVIAMIGSGYFVGKLMNMYPVE SAIVTCCHSGLGGTGDVAILSASGRMGLMPFAQISTRLGGAGTVICATVLLRFFTS*" /label="maeN CDS" gene 2895885..2897231 /gene="maeN" /locus_tag="BSU_31580" /old_locus_tag="BSU31580" /label="maeN gene" downshifts 2897214 /Source="Nicolas_upshifts" /id="D1636" /incds=0 /nref=68 /ntot=109 /MaxReadThrough="0.286069999999999" /MaxDrop="6.51197" /score="36.240717" /energy="-12.2" /TU="NA" /idTUdmin="U2461" /TUdmin="-12" /isTUend="TRUE" /label="downshifts" CDS complement(2897267..2897482) /gene="yufS" /locus_tag="BSU_31590" /old_locus_tag="BSU31590" /function="16.8: Protect" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16845009; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative bacteriocin" /protein_id="NP_391037.1" /db_xref="EnsemblGenomes-Gn:BSU31590" /db_xref="EnsemblGenomes-Tr:CAB15148" /db_xref="GOA:O05257" /db_xref="SubtiList:BG12354" /db_xref="UniProtKB/Swiss-Prot:O05257" /translation="MKTKVVMCSGLFCSVFAGAFMLNQYDGRSGVAACDEWELYLLEH HLSARMSETESKDLPFGPREYIRIVNK*" /label="yufS CDS" gene complement(2897267..2897482) /gene="yufS" /locus_tag="BSU_31590" /old_locus_tag="BSU31590" /label="yufS gene" promotor_-35 2897422..2897428 /Source="Nicolas_upshift_promotors" /id="U2462" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=877 /SigmaFactorBS="ccgccacaccgctgcgcccgtcatattgattcaacaTGAATG CccctgcaaatactGAGCAGAATAAAcctgagcacatcacgacttttgttttcacatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2897442..2897453 /Source="Nicolas_upshift_promotors" /id="U2462" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=877 /SigmaFactorBS="ccgccacaccgctgcgcccgtcatattgattcaacaTGAATG CccctgcaaatactGAGCAGAATAAAcctgagcacatcacgacttttgttttcacatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2897446 /Source="Nicolas_upshifts" /id="U2462" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=877 /SigmaFactorBS="ccgccacaccgctgcgcccgtcatattgattcaacaTGAATG CccctgcaaatactGAGCAGAATAAAcctgagcacatcacgacttttgttttcacatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2897493..2897511) /Source="Nicolas_upshift_promotors" /id="U2463" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.696303696303696" /psig="0.696303696303696" /xcortree=1197 /SigmaFactorBS="aaataagtctaacaaaaaagaggttattTGTATAtttaaaat caatcctGATCAAGCTGAAGGAAAGGagctggtcatgtgaaaacaaaagtcgtgatgt g" /listShort="yufS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2897500) /Source="Nicolas_upshifts" /id="U2463" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.696303696303696" /psig="0.696303696303696" /xcortree=1197 /SigmaFactorBS="aaataagtctaacaaaaaagaggttattTGTATAtttaaaat caatcctGATCAAGCTGAAGGAAAGGagctggtcatgtgaaaacaaaagtcgtgatgt g" /listShort="yufS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2897525..2897532 /Source="Nicolas_upshift_promotors" /id="U2464" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96103896103896" /psig="0.998001998001998" /xcortree=1758 /SigmaFactorBS="ccagctcctttccttcagcttgatcaggattgattttaAATA TACAaataacctctttttTGTTAGACTTATTTTGAGGTcaaaagaactcataaaaatc c" /listShort="S1210, S1211, mrpA, mrpB, mrpC, mrpD, mrpE, mrpF, mrpG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(2897527..2897532) /Source="Nicolas_upshift_promotors" /id="U2463" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.696303696303696" /psig="0.696303696303696" /xcortree=1197 /SigmaFactorBS="aaataagtctaacaaaaaagaggttattTGTATAtttaaaat caatcctGATCAAGCTGAAGGAAAGGagctggtcatgtgaaaacaaaagtcgtgatgt g" /listShort="yufS" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2897547..2897642 /Source="Nicolas_S_feature" /locus_tag="new_3246432_3246527" /HighExp="G180, Diami, G150, Oxctl, G135, H2O2, Paraq, MG 60, MG 15, MG 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1210" promotor_-10 2897547..2897566 /Source="Nicolas_upshift_promotors" /id="U2464" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96103896103896" /psig="0.998001998001998" /xcortree=1758 /SigmaFactorBS="ccagctcctttccttcagcttgatcaggattgattttaAATA TACAaataacctctttttTGTTAGACTTATTTTGAGGTcaaaagaactcataaaaatc c" /listShort="S1210, S1211, mrpA, mrpB, mrpC, mrpD, mrpE, mrpF, mrpG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2897547 /Source="Nicolas_upshifts" /id="U2464" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96103896103896" /psig="0.998001998001998" /xcortree=1758 /SigmaFactorBS="ccagctcctttccttcagcttgatcaggattgattttaAATA TACAaataacctctttttTGTTAGACTTATTTTGAGGTcaaaagaactcataaaaatc c" /listShort="S1210, S1211, mrpA, mrpB, mrpC, mrpD, mrpE, mrpF, mrpG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2897605..2897609 /Source="Nicolas_upshift_promotors" /id="U2465" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.868131868131868" /psig="0.999000999001" /xcortree=2700 /SigmaFactorBS="atccattacagcagttcgaagCGTGGcagcttgcagaaaagT GCGATATAATTTGGACTAGgtcgtttgaccgtatattttatacatagcgcatttttca a" /listShort="S1211, mrpA, mrpB, mrpC, mrpD, mrpE, mrpF, mrpG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2897625..2897644 /Source="Nicolas_upshift_promotors" /id="U2465" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.868131868131868" /psig="0.999000999001" /xcortree=2700 /SigmaFactorBS="atccattacagcagttcgaagCGTGGcagcttgcagaaaagT GCGATATAATTTGGACTAGgtcgtttgaccgtatattttatacatagcgcatttttca a" /listShort="S1211, mrpA, mrpB, mrpC, mrpD, mrpE, mrpF, mrpG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2897644..2897793 /Source="Nicolas_S_feature" /locus_tag="new_3246529_3246678" /HighExp="G135, G180, Diami, G150, H2O2, Oxctl, LBGexp, Paraq, Salt, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1211" upshifts 2897644 /Source="Nicolas_upshifts" /id="U2465" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.868131868131868" /psig="0.999000999001" /xcortree=2700 /SigmaFactorBS="atccattacagcagttcgaagCGTGGcagcttgcagaaaagT GCGATATAATTTGGACTAGgtcgtttgaccgtatattttatacatagcgcatttttca a" /listShort="S1211, mrpA, mrpB, mrpC, mrpD, mrpE, mrpF, mrpG" /GFF_Attribute="listLong" /label="upshifts" CDS 2897713..2900118 /gene="mrpA" /locus_tag="BSU_31600" /old_locus_tag="BSU31600" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11004162, 11356194, 12682299, 15019740, 15849754, 16850406, 17693497, 21236240, 24095649, 24139955, 27391676" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11004162, 11356194, 12682299, 15019740, 15849754, 16850406, 17693497, 21236240, 24095649, 24139955, 27391676; Product type t : transporter" /codon_start=1 /transl_table=11 /product="sodium transporter component of a Na+/H+ antiporter" /protein_id="NP_391038.2" /db_xref="EnsemblGenomes-Gn:BSU31600" /db_xref="EnsemblGenomes-Tr:CAB15149" /db_xref="GOA:Q9K2S2" /db_xref="InterPro:IPR001516" /db_xref="InterPro:IPR001750" /db_xref="InterPro:IPR005663" /db_xref="InterPro:IPR018393" /db_xref="InterPro:IPR025383" /db_xref="SubtiList:BG12355" /db_xref="UniProtKB/Swiss-Prot:Q9K2S2" /translation="MQLLHLAILSPFLFAFIIPFLAKYAKRVHTGWFVLILPVLLFIY FLPMIRMTQSGETLRSVLEWIPSLGINFTVYIDGLGLLFALLITGIGSLVTLYSIFYL SKEKEQLGPFYVYLLMFMGAMLGVVLVDNVMVLYMFWELTSLSSFLLIGYWYKREKSR YGAAKSLLITVSGGLCMLGGFILLYLITDSFSIREMVHQVQLIAGHELFIPAMILILL GAFTKSAQFPFYIWLPDAMEAPTPVSAYLHSATMVKAGIYVIARFSPIFAFSAQWFWI VSLVGLFTMVWGSFHAVKQTDLKSILAFSTVSQLGMIISMLGVSAAALHYGHTEYYTV AAMAAIFHLINHATFKGSLFMAVGIIDHETGTRDIRKLGGLMAIMPITFTISLIGTFS MAGLPPFNGFLSKEMFFTSMLRVTHFDLFNVQTWGVLFPLFAWIGSVFTFIYSMKLLF KTFRGNYQPEQLEKQAHEAPVGMLVPPVILVALAVSLFFFPNILSYSLIEPAMNSIYP TLLDGHEKFHVHISQWHGVTTELLMTAGIVVIGTIGYLSLNKWKGIYKLFPSKLTLNR LYDKLLTMMEKGSYRVTKQYMTGFLRDYLLYIFAGFIILIGGAFAIKGGFSFKTEGMA KIGVYEIILTLVMISATVATVFARSRLTAIIALGVVGYTLALFFVIFRAPDLALTQLV IETISVALFLLCFYHLPKLRLKTKTRTFRMTNFIISLGVGVIVTLLGIASSSQRTKDS IASFFVKHSHDLGGGDNVVNVILVDFRGFDTMFEITVLTIAALGIYSMIKTKVKEEGK SGE*" /label="mrpA CDS" gene 2897713..2900118 /gene="mrpA" /locus_tag="BSU_31600" /old_locus_tag="BSU31600" /label="mrpA gene" CDS 2900111..2900542 /gene="mrpB" /locus_tag="BSU_31610" /old_locus_tag="BSU31610" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11004162, 11356194, 12682299, 15019740, 15849754, 16850406, 17693497, 19389778" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11004162, 11356194, 12682299, 15019740, 15849754, 16850406, 17693497, 19389778; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Na+/H+ antiporter complex" /protein_id="NP_391039.1" /db_xref="EnsemblGenomes-Gn:BSU31610" /db_xref="EnsemblGenomes-Tr:CAB15150" /db_xref="GOA:O05259" /db_xref="InterPro:IPR005281" /db_xref="InterPro:IPR007182" /db_xref="SubtiList:BG12356" /db_xref="UniProtKB/Swiss-Prot:O05259" /translation="MNEQKTNDLILQTATKLVSFIILLFSFYLFLSGHNAPGGGFVGG LITSSSIVLLLLAYDLKTVRSLLPVNFIYVAGAGLLLAVLTGVGSFVFGAPFLTHTFG YFQLPILGKTELATATIFDLGVYLVVVGITMTIIQTIGEEE*" /label="mrpB CDS" gene 2900111..2900542 /gene="mrpB" /locus_tag="BSU_31610" /old_locus_tag="BSU31610" /label="mrpB gene" CDS 2900542..2900883 /gene="mrpC" /locus_tag="BSU_31620" /old_locus_tag="BSU31620" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11004162, 11356194, 12682299, 15019740, 15849754, 16850406, 17693497, 24021651" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11004162, 11356194, 12682299, 15019740, 15849754, 16850406, 17693497, 24021651; Product type t: transporter" /codon_start=1 /transl_table=11 /product="component of Na+/H+ antiporter" /protein_id="NP_391040.2" /db_xref="EnsemblGenomes-Gn:BSU31620" /db_xref="EnsemblGenomes-Tr:CAB15151" /db_xref="GOA:O05260" /db_xref="SubtiList:BG12357" /db_xref="UniProtKB/Swiss-Prot:O05260" /translation="MEILMAVLAGIIFMAATYLLLSKSLLRVIIGTALLSHGVHLMLL TMGGLKKGAAPILSEHAKSFVDPLPQALILTAIVISFGVTSFILVMAFRAYQELKSDD MDQMRGNDQHE*" /label="mrpC CDS" gene 2900542..2900883 /gene="mrpC" /locus_tag="BSU_31620" /old_locus_tag="BSU31620" /label="mrpC gene" promotor_no_box 2900774..2900874 /Source="Nicolas_upshift_promotors" /id="U2466" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.387612387612388" /psig="0.387612387612388" /xcortree=1779 /SigmaFactorBS="tcatttcttttggcgttacgtcattcatcctcgtcatggcct ttcgcgcttatcaggaattgaaatcggacgatatggatcaaatgaggggaaatgatca a" /listShort="mrpD, mrpE, mrpF, mrpG" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 2900834 /Source="Nicolas_upshifts" /id="U2466" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.387612387612388" /psig="0.387612387612388" /xcortree=1779 /SigmaFactorBS="tcatttcttttggcgttacgtcattcatcctcgtcatggcct ttcgcgcttatcaggaattgaaatcggacgatatggatcaaatgaggggaaatgatca a" /listShort="mrpD, mrpE, mrpF, mrpG" /GFF_Attribute="listLong" /label="upshifts" CDS 2900876..2902357 /gene="mrpD" /locus_tag="BSU_31630" /old_locus_tag="BSU31630" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11004162, 11356194, 12682299, 15019740, 15849754, 16850406, 21236240, 24095649, 27391676" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11004162, 11356194, 12682299, 15019740, 15849754, 16850406, 21236240, 24095649, 27391676; Product type t: transporter" /codon_start=1 /transl_table=11 /product="proton transporter component of Na+/H+ antiporter" /protein_id="NP_391041.3" /db_xref="EnsemblGenomes-Gn:BSU31630" /db_xref="EnsemblGenomes-Tr:CAB15152" /db_xref="GOA:O05229" /db_xref="InterPro:IPR001750" /db_xref="InterPro:IPR003918" /db_xref="InterPro:IPR004775" /db_xref="SubtiList:BG12345" /db_xref="UniProtKB/Swiss-Prot:O05229" /translation="MNNFVILPILIPLLSAILLIFMTKNLMLMRIFSTAASAIGIVIS GILVQTVFTKGIQTLSLGGWKAPYGIVLAADQFASLLVLTTAIIGLLVGLYSFRSVGE KRERSFYYSGVQFLLAGVSGAFLTGDLFNMYVFFELLLIASYMLIVLGGTKIQLRESL KYIVFNIVSSALFVIGVGFLYAVTGTLNMADLSVKISESGQTGLITVIGVLLLLVFGM KGGIFPLYFWLPGSYYAPPAAISALFGALLTKVGLYAITRVFTLIFIHDTAFTHQLMI WLAALTVIFGVIGSLAYSNVMKIVIYNIITAVGVILFGVAVHTPASIQGAIYYLIHDM LIKGALFMLAGTLIALTGTASLHKMGGLIKRYPVLGWMFFISAISLAGIPPLSGFVGK FKIAEGGFAEGEFTISMLILLSSLLVLYSVLRIFIHAFWGEEKETPKPNHRTAKGLLY PAAIFLLLSLLFGLGTEWVSPYVDQAAETLLNPEKYIEAVLKE*" /label="mrpD CDS" gene 2900876..2902357 /gene="mrpD" /locus_tag="BSU_31630" /old_locus_tag="BSU31630" /label="mrpD gene" S_feature complement(2901609..2903477) /Source="Nicolas_S_feature" /locus_tag="new_3250494_3252362_c" /HighExp="S2, Lbstat, T5.0H, T3.30H, S3, T4.0H, T3.0H, T2.30H, S1, T2.0H" /AntisenseName="mrpD" /AntisenseCor="-0.59706140653928796" /AntisenseRegPval="-26.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S1212" CDS 2902363..2902839 /gene="mrpE" /locus_tag="BSU_31640" /old_locus_tag="BSU31640" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10198001, 11004162, 15849754, 16233411, 16850406, 24142251" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10198001, 11004162, 15849754, 16233411, 16850406, 24142251; Product type t : transporter" /codon_start=1 /transl_table=11 /product="non essential component of Na+/H+ antiporter" /protein_id="YP_054591.2" /db_xref="EnsemblGenomes-Gn:BSU31640" /db_xref="EnsemblGenomes-Tr:CAE01465" /db_xref="GOA:Q7WY60" /db_xref="InterPro:IPR002758" /db_xref="SubtiList:BG14181" /db_xref="UniProtKB/Swiss-Prot:Q7WY60" /translation="MAFQILLNVFLAFCWMFLSNSPSAAGFITGYILGMLSLFFFRRF FTRQFYLWKLISIIKLCFIFIKELYLANVSVMKSVLSPKLNIRPGIFAFKTELTKDWE ITMLSLLITLTPGTLVMDISDDRTILYIHAMDIEDAEKAIFDIRESFEKAIQEVSR*" /label="mrpE CDS" gene 2902363..2902839 /gene="mrpE" /locus_tag="BSU_31640" /old_locus_tag="BSU31640" /label="mrpE gene" CDS 2902839..2903123 /gene="mrpF" /locus_tag="BSU_31650" /old_locus_tag="BSU31650" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10198001, 11004162, 11356194, 12682299, 15019740, 24142251" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10198001, 11004162, 11356194, 12682299, 15019740, 24142251; Product type t : transporter" /codon_start=1 /transl_table=11 /product="efflux transporter for Na+ and cholate" /protein_id="NP_391043.2" /db_xref="EnsemblGenomes-Gn:BSU31650" /db_xref="EnsemblGenomes-Tr:CAB15153" /db_xref="GOA:O05228" /db_xref="InterPro:IPR007208" /db_xref="SubtiList:BG12344" /db_xref="UniProtKB/Swiss-Prot:O05228" /translation="MFTLILQIALGIMAVSTFLYVIRVIKGPTVPDRVVALDAIGINL IAITALVSILLKTSAFLDIILLLGILSFIGTIAFSKFLEKGEIIENDRNR*" /label="mrpF CDS" gene 2902839..2903123 /gene="mrpF" /locus_tag="BSU_31650" /old_locus_tag="BSU31650" /label="mrpF gene" CDS 2903107..2903481 /gene="mrpG" /locus_tag="BSU_31660" /old_locus_tag="BSU31660" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11004162, 11356194, 15019740, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11004162, 11356194, 15019740, 15849754, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="non essential component of Na+/H+ antiporter" /protein_id="NP_391044.1" /db_xref="EnsemblGenomes-Gn:BSU31660" /db_xref="EnsemblGenomes-Tr:CAB15154" /db_xref="GOA:O05227" /db_xref="InterPro:IPR005133" /db_xref="SubtiList:BG12343" /db_xref="UniProtKB/Swiss-Prot:O05227" /translation="MIETAKVVVAVFILLGALICLIASFGVLRLPDVFTRAHAASKGS TLGVNMILLGVFFYLWFVTGELSAKILLGILFIFITSPIGGHLICRAAYNSGVKLDER SVQDDYNGIRNFVIKRKEDSYL*" /label="mrpG CDS" gene 2903107..2903481 /gene="mrpG" /locus_tag="BSU_31660" /old_locus_tag="BSU31660" /label="mrpG gene" downshifts 2903452 /Source="Nicolas_upshifts" /id="D1637" /incds=0 /nref=86 /ntot=185 /MaxReadThrough="1.46493" /MaxDrop="6.023" /score="32.1865197" /energy="-12.7" /TU="NA" /idTUdmin="U2464" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2903520..2903900) /gene="yuxO" /locus_tag="BSU_31670" /old_locus_tag="BSU31670" /EC_number="3.1.-.-" /function="18.1: Enzymes of unknown specificity" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 25010423; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative proofreading thioesterase in bacillibactin biosynthesis" /protein_id="NP_391045.2" /db_xref="EnsemblGenomes-Gn:BSU31670" /db_xref="EnsemblGenomes-Tr:CAB15155" /db_xref="GOA:P14205" /db_xref="InterPro:IPR003736" /db_xref="InterPro:IPR006683" /db_xref="InterPro:IPR029069" /db_xref="SubtiList:BG10382" /db_xref="UniProtKB/Swiss-Prot:P14205" /translation="MDMKHTLLEALGIEIVENTAERCVAVMPVDHRTVQPFGYLHGGA SVALAETAASAGAQNLIDHTTQACVGLEINANHLKSVKEGTVKAIAEPVHIGRTTIVY HIHIYDEQERLICISRCTLAVIKK*" /label="yuxO CDS" gene complement(2903520..2903900) /gene="yuxO" /locus_tag="BSU_31670" /old_locus_tag="BSU31670" /label="yuxO gene" downshifts complement(2903522) /Source="Nicolas_upshifts" /id="D1638" /incds=0 /nref=41 /ntot=206 /MaxReadThrough="4.53972" /MaxDrop="3.98532" /score="-4.4938943" /energy="-12.7" /TU="U2469" /idTUdmin="U2469" /TUdmin="-1050" /isTUend="FALSE" /label="downshifts" CDS complement(2903919..2904563) /gene="comA" /locus_tag="BSU_31680" /old_locus_tag="BSU31680" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10972833, 11179649, 11717295, 12950917, 16816200, 17827323, 26582911" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10972833, 11179649, 11717295, 12950917, 16816200, 17827323, 26582911; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response quorum-sensing regulator" /protein_id="NP_391046.1" /db_xref="EnsemblGenomes-Gn:BSU31680" /db_xref="EnsemblGenomes-Tr:CAB15156" /db_xref="GOA:P14204" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="PDB:2KRF" /db_xref="PDB:3ULQ" /db_xref="SubtiList:BG10381" /db_xref="UniProtKB/Swiss-Prot:P14204" /translation="MKKILVIDDHPAVMEGTKTILETDSNLSVDCLSPEPSEQFIKQH DFSSYDLILMDLNLGGEVNGMELSKQILQENPHCKIIVYTGYEVEDYFEEAIRAGLHG AISKTESKEKITQYIYHVLNGEILVDFAYFKQLMTQQKTKPAPSSQKEQDVLTPRECL ILQEVEKGFTNQEIADALHLSKRSIEYSLTSIFNKLNVGSRTEAVLIAKSDGVL*" /label="comA CDS" gene complement(2903919..2904563) /gene="comA" /locus_tag="BSU_31680" /old_locus_tag="BSU31680" /label="comA gene" S_feature complement(2904564..2904643) /Source="Nicolas_S_feature" /locus_tag="new_3253449_3253528_c" /HighExp="S2, Lbstat, M0t90, M40t90, MG 5, S1, ferm, T1.30H, nit, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S1213" CDS complement(2904644..2906953) /gene="comP" /locus_tag="BSU_31690" /old_locus_tag="BSU31690" /EC_number="2.7.-.-" /function="16.12: Sense" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 7698645, 7855425, 10419951, 14679219, 15066026, 16091050, 16787201, 20208433, 24130811; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase" /protein_id="NP_391047.2" /db_xref="EnsemblGenomes-Gn:BSU31690" /db_xref="EnsemblGenomes-Tr:CAB15157" /db_xref="GOA:Q99027" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG10380" /db_xref="UniProtKB/Swiss-Prot:Q99027" /translation="MKNLIKKFTIAVIVLSILYISYTTYISMNGIIIGTKIHKNDKSQ FMIEEISESSYGQFVGLRQGDIILKINKEKPSDKHLKWGYLSHINSLDILRSGKKIHL KDFDLVTLNRPYSFFLFVLPLFFYFLSIICIFYILKVNKKRRSFAAYILILLLLDISI AYISAGGPFRGHIINRYINLFTFISSPILYLQFIQRYLGEIGKTFLNRISFLYIIPIF NLGIEFFQDYLQVDIDFLATLNLVSFATLTLFSFSAIYLHLNKYKYAEHSFILKLLIL TNTLSFAPFLIFFVLPIIFTGNYIFPALASASLLVLIPFGLVYQFVANKMFDIEFILG RMRYYALLAMIPTLLIVGALVLFDVMDIQMNPVRQTVFFFVVMFAVFYFKEVMDFKFR LKRFSEKFNYQDSIFKYTQLMRGVTSLQQVFKELKNTILDVLLVSKAYTFEVTPDHKV IFLDKHEVGPDWNFYQEEFENVTSEIGKIIEVNQGFLMKVGERGGSSYVLLCLSNINT PRLTRDEISWLKTLSFYTSVSMENVLHIEELMEHLKDLKQEGTNPIWLKKLMFAIEEK QRSGLARDLHDSVLQDLISLKRQCELFLGDFKKDDNPCREEVQDKLVQMNEQMSDVIS MTRETCHELRPQLLYDLGLVKALSKLVAQQQERVPFHIRLNTGRFTASLDLDSQLNLY RIIQEFLSNAVKHSQATDVLIMLISIQNKIVLHYEDDGVGFDQEKNTEHSMSMGLSGI KERVRALDGRLRIETSEGKGFKADIEIEL*" /label="comP CDS" gene complement(2904644..2906953) /gene="comP" /locus_tag="BSU_31690" /old_locus_tag="BSU31690" /label="comP gene" promotor_-35 2905638..2905645 /Source="Nicolas_upshift_promotors" /id="U2467" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.783216783216783" /psig="0.998001998001998" /xcortree=1977 /SigmaFactorBS="tcaggagtaacctcaaaggtataaGCTTTGCTtacaagcaaa acaTCCAGTATAGTATTTTTCAGttctttaaaaacttgttgaagagaagttacacccc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2905659..2905678 /Source="Nicolas_upshift_promotors" /id="U2467" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.783216783216783" /psig="0.998001998001998" /xcortree=1977 /SigmaFactorBS="tcaggagtaacctcaaaggtataaGCTTTGCTtacaagcaaa acaTCCAGTATAGTATTTTTCAGttctttaaaaacttgttgaagagaagttacacccc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2905674 /Source="Nicolas_upshifts" /id="U2467" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.783216783216783" /psig="0.998001998001998" /xcortree=1977 /SigmaFactorBS="tcaggagtaacctcaaaggtataaGCTTTGCTtacaagcaaa acaTCCAGTATAGTATTTTTCAGttctttaaaaacttgttgaagagaagttacacccc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature 2906547..2907518 /Source="Nicolas_S_feature" /locus_tag="new_3255432_3256404" /HighExp="S8, C30, S7, Gly, Lbstat, Fru, C90, Pyr, G135, M/G" /AntisenseName="comX" /AntisenseCor="-2.6572990440080099E-2" /AntisenseRegPval="-0.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.606" /TUlongSig="NA" /TUlongPSig="NA" /label="S1214" upshifts 2906547 /Source="Nicolas_upshifts" /id="U2468" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.281718281718282" /psig="0.606393606393606" /xcortree=660 /SigmaFactorBS="aataacaatagaataagaatataggcagcaaatgatctcctt tttttatttactttaagtatataaaaaataCATATTATGCTTAAAAAataaaaaaaca a" /listShort="S1214" /GFF_Attribute="listLong" /label="upshifts" misc_feature 2906559..2906575 /Source="Nicolas_upshift_promotors" /id="U2468" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.281718281718282" /psig="0.606393606393606" /xcortree=660 /SigmaFactorBS="aataacaatagaataagaatataggcagcaaatgatctcctt tttttatttactttaagtatataaaaaataCATATTATGCTTAAAAAataaaaaaaca a" /listShort="S1214" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(2906968..2907135) /gene="comX" /locus_tag="BSU_31700" /old_locus_tag="BSU31700" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11751817, 12067344, 14679219, 16407988, 17240141, 18323630, 21636272, 21821957, 28326143, 28391484" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11751817, 12067344, 14679219, 16407988, 17240141, 18323630, 21636272, 21821957, 28326143, 28391484; Product type f: factor" /codon_start=1 /transl_table=11 /product="competence pheromone precursor (pheromone peptide aa 46->55, geranyl-modified)" /protein_id="NP_391048.1" /db_xref="EnsemblGenomes-Gn:BSU31700" /db_xref="EnsemblGenomes-Tr:CAB15158" /db_xref="GOA:P45453" /db_xref="InterPro:IPR009233" /db_xref="SubtiList:BG11324" /db_xref="UniProtKB/Swiss-Prot:P45453" /translation="MQDLINYFLNYPEALKKLKNKEACLIGFDVQETETIIKAYNDYY LADPITRQWGD*" /label="comX CDS" gene complement(2906968..2907135) /gene="comX" /locus_tag="BSU_31700" /old_locus_tag="BSU31700" /label="comX gene" CDS complement(2907123..2908021) /gene="comQ" /locus_tag="BSU_31710" /old_locus_tag="BSU31710" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11751817, 12067344, 14679219, 16407988, 16452308, 17240141, 22878193, 24425772, 25036949" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11751817, 12067344, 14679219, 16407988, 16452308, 17240141, 22878193, 24425772, 25036949; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isoprenyl transferase (pre-ComX modification)" /protein_id="NP_391049.2" /db_xref="EnsemblGenomes-Gn:BSU31710" /db_xref="EnsemblGenomes-Tr:CAB15159" /db_xref="GOA:P33690" /db_xref="InterPro:IPR000092" /db_xref="InterPro:IPR008949" /db_xref="InterPro:IPR033965" /db_xref="SubtiList:BG10379" /db_xref="UniProtKB/Swiss-Prot:P33690" /translation="MKEIVEQNIFNEDLSQLLYSFIDSKETFSFAESTILHYVVFGGE NLDVATRLGAGIEILILSSDIMDDLEDEDNHHALWMKINRSESLNAALSLYTVGLTSI YSLNNNPLIFKYVLKYVNEAMQGQHDDITNKSKTEDESLEVIRLKCGSLIALANVAGV LLATGEYNETVERYSYYKGIIAQISGDYYVLLSGNRSDIEKNKHTLIYLYLKRLFNDA SEDLLYLISHKDLYYKSLLDKEKFQEKLIKAGVTQYISVLLEIYKQKCISAIEQLNLD KEKKS**RNAY*VIQRGIQDARP" /label="comQ CDS" gene complement(2907123..2908021) /gene="comQ" /locus_tag="BSU_31710" /old_locus_tag="BSU31710" /label="comQ gene" S_feature complement(2908022..2908135) /Source="Nicolas_S_feature" /locus_tag="new_3256908_3257021_c" /HighExp="M9-stat, T1.30H, T0.30H, T1.0H, S4, T2.30H, M0t90, S5, M40t90, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S1215" promotor_-10 complement(2908129..2908148) /Source="Nicolas_upshift_promotors" /id="U2469" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.376623376623377" /psig="0.987012987012987" /xcortree=3084 /SigmaFactorBS="gaaacaagtcttttttttcgttctaccGATACAAtaaatgga taaagTATTATATGATTGTTAAAAAacgaaaaacctgctgtcctttaaatgtcccatt t" /listShort="S1215, comQ, comX, comP, S1213, comA, yuxO, S1212" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2908135) /Source="Nicolas_upshifts" /id="U2469" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.376623376623377" /psig="0.987012987012987" /xcortree=3084 /SigmaFactorBS="gaaacaagtcttttttttcgttctaccGATACAAtaaatgga taaagTATTATATGATTGTTAAAAAacgaaaaacctgctgtcctttaaatgtcccatt t" /listShort="S1215, comQ, comX, comP, S1213, comA, yuxO, S1212" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2908162..2908168) /Source="Nicolas_upshift_promotors" /id="U2469" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.376623376623377" /psig="0.987012987012987" /xcortree=3084 /SigmaFactorBS="gaaacaagtcttttttttcgttctaccGATACAAtaaatgga taaagTATTATATGATTGTTAAAAAacgaaaaacctgctgtcctttaaatgtcccatt t" /listShort="S1215, comQ, comX, comP, S1213, comA, yuxO, S1212" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2908206..2908346) /gene="degQ" /locus_tag="BSU_31720" /old_locus_tag="BSU31720" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1901055, 16251307, 16942812, 17827323, 21965392, 26302846, 27920766" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1901055, 16251307, 16942812, 17827323, 21965392, 26302846, 27920766; Product type r: regulator" /codon_start=1 /transl_table=11 /product="pleiotropic regulator" /protein_id="NP_391050.1" /db_xref="EnsemblGenomes-Gn:BSU31720" /db_xref="EnsemblGenomes-Tr:CAB15160" /db_xref="GOA:Q99039" /db_xref="InterPro:IPR012554" /db_xref="SubtiList:BG10378" /db_xref="UniProtKB/Swiss-Prot:Q99039" /translation="MEKKLEEVKQLLFRLELDIKETTDSLRNINKSIDQLDKYNYAMK IS*" /label="degQ CDS" gene complement(2908206..2908346) /gene="degQ" /locus_tag="BSU_31720" /old_locus_tag="BSU31720" /label="degQ gene" downshifts complement(2908235) /Source="Nicolas_upshifts" /id="D1639" /incds=0 /nref=2 /ntot=28 /MaxReadThrough="2.48672" /MaxDrop="4.10905" /score="21.4973657" /energy="-6.5" /TU="NA" /idTUdmin="U2470" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2908347..2908433) /Source="Nicolas_S_feature" /locus_tag="new_3257233_3257319_c" /HighExp="S2, S4, BC, M9-stat, S5, S3, S6, BT, S8, S7" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.843" /TUlongSig="NA" /TUlongPSig="NA" /label="S1216" promotor_-10 complement(2908417..2908436) /Source="Nicolas_upshift_promotors" /id="U2470" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.38961038961039" /psig="0.843156843156843" /xcortree=464 /SigmaFactorBS="atttgcggtgtcacgcaggacttttttgcatacttttCGGTG AAaaatgagccgaaaGCAGACACACTATTAGTAACagatcaaatacctaggactcgtt c" /listShort="S1216, degQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2908433) /Source="Nicolas_upshifts" /id="U2470" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.38961038961039" /psig="0.843156843156843" /xcortree=464 /SigmaFactorBS="atttgcggtgtcacgcaggacttttttgcatacttttCGGTG AAaaatgagccgaaaGCAGACACACTATTAGTAACagatcaaatacctaggactcgtt c" /listShort="S1216, degQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2908450..2908456) /Source="Nicolas_upshift_promotors" /id="U2470" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.38961038961039" /psig="0.843156843156843" /xcortree=464 /SigmaFactorBS="atttgcggtgtcacgcaggacttttttgcatacttttCGGTG AAaaatgagccgaaaGCAGACACACTATTAGTAACagatcaaatacctaggactcgtt c" /listShort="S1216, degQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2908533..2908551) /Source="Nicolas_upshift_promotors" /id="U2471" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.521478521478521" /psig="0.521478521478521" /xcortree=1454 /SigmaFactorBS="atcaaggagattaagaatctttctcaatttcAGCACATataa acgctctttcGCATAGAAAGATAGTCCCGttcttgttgtgattcctttgagtataagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2908543) /Source="Nicolas_upshifts" /id="U2471" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.521478521478521" /psig="0.521478521478521" /xcortree=1454 /SigmaFactorBS="atcaaggagattaagaatctttctcaatttcAGCACATataa acgctctttcGCATAGAAAGATAGTCCCGttcttgttgtgattcctttgagtataagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2908566..2908572) /Source="Nicolas_upshift_promotors" /id="U2471" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.521478521478521" /psig="0.521478521478521" /xcortree=1454 /SigmaFactorBS="atcaaggagattaagaatctttctcaatttcAGCACATataa acgctctttcGCATAGAAAGATAGTCCCGttcttgttgtgattcctttgagtataagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2908568..2908693 /locus_tag="BSU_31725" /old_locus_tag="BSU31725" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514001.1" /translation="MLKLRKILNLLDFNGFRIFTKQDYSPSYRIFKIEYAILGVS*" /label="hypothetical protein CDS" gene 2908568..2908693 /locus_tag="BSU_31725" /old_locus_tag="BSU31725" /label="gene" S_feature complement(2908721..2909150) /Source="Nicolas_S_feature" /locus_tag="new_3257607_3258036_c" /HighExp="LBGtran, G135, C90, Lbtran, Mt0, Lbexp, G150, G180, M40t45, C30" /AntisenseName="yuzC" /AntisenseCor="-0.77553193168722701" /AntisenseRegPval="-54.5" /CDS_PredictionProba="0.143959" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1217" promotor_-35 2908746..2908751 /Source="Nicolas_upshift_promotors" /id="U2472" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1158 /SigmaFactorBS="aaaagaccgcaacgctaaagttgtggccttttcgctttGTCA TAttcggcaattagggATCTATACATATAGAAACAtccttttttgcgaggtgctccca t" /listShort="yuzC, S1218" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2908763) /Source="Nicolas_upshifts" /id="D1640" /incds=0 /nref=23 /ntot=170 /MaxReadThrough="2.53578" /MaxDrop="3.52021" /score="21.4973657" /energy="-6.5" /TU="NA" /idTUdmin="U2473" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 2908766..2908784 /Source="Nicolas_upshift_promotors" /id="U2472" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1158 /SigmaFactorBS="aaaagaccgcaacgctaaagttgtggccttttcgctttGTCA TAttcggcaattagggATCTATACATATAGAAACAtccttttttgcgaggtgctccca t" /listShort="yuzC, S1218" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2908768 /Source="Nicolas_upshifts" /id="U2472" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1158 /SigmaFactorBS="aaaagaccgcaacgctaaagttgtggccttttcgctttGTCA TAttcggcaattagggATCTATACATATAGAAACAtccttttttgcgaggtgctccca t" /listShort="yuzC, S1218" /GFF_Attribute="listLong" /label="upshifts" CDS 2908807..2909175 /gene="cotIC" /locus_tag="BSU_31730" /old_locus_tag="BSU31730" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:16321932" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16321932; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="inner spore coat protein" /protein_id="NP_391051.2" /db_xref="EnsemblGenomes-Gn:BSU31730" /db_xref="EnsemblGenomes-Tr:CAB15161" /db_xref="InterPro:IPR016559" /db_xref="SubtiList:BG14052" /db_xref="UniProtKB/Swiss-Prot:O32089" /translation="MRYRYPWFYVYPYEVRRPPAPANNIDTFIRSAKQAAGIFADAQL VLSRIAGSRELSRRILTAAEQSDKQTIRRLIKQMGVRHEVDTVFNPDGIYISLIGTQS RMILALRWSEDRNHFASIRL*" /label="cotIC CDS" gene 2908807..2909175 /gene="cotIC" /locus_tag="BSU_31730" /old_locus_tag="BSU31730" /label="cotIC gene" CDS complement(2909151..2910380) /gene="pdeH" /locus_tag="BSU_31740" /old_locus_tag="BSU31740" /EC_number="3.1.4.52" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17153922, 23893111, 28536559" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17153922, 23893111, 28536559; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cyclic di-GMP phosphodiesterase" /protein_id="NP_391052.1" /db_xref="EnsemblGenomes-Gn:BSU31740" /db_xref="EnsemblGenomes-Tr:CAB15162" /db_xref="InterPro:IPR001633" /db_xref="InterPro:IPR013976" /db_xref="InterPro:IPR014408" /db_xref="InterPro:IPR035919" /db_xref="SubtiList:BG10377" /db_xref="UniProtKB/Swiss-Prot:P14203" /translation="MRVFVARQPIFNRKEQVVAYELLYRESEENVYSAKDGDQATTDL VINSFLNIGIEKLTEGKRCFVNFTESLMFSNLPTSFNPKQLVIEILEDIPITPALISR CKELKKMGYMLALDDFYAINPQDEDLLEKLMSYIDILKIDFLKTTRMERRTILQTYGC RGLIFLAEKVETRKEYKQAVQDGFQLFQGYFFSEPRIISGHDLSTHFYSYYELLNELS KEQPNIKRVTEYIERDLSLSYQILKFLNSSHSRLSQKIESIQQAIMLLGFNEIKRWIY ILSFKDLSRKGHSSKHEIIKISLIRAKLCELLARKTSRPQPASYMLIGMFSLIDTLLH REIEEIVQELPLKDEVGQALLGHQNDYYQMLELVKLIESNNWDTCSELGNQLDKEEAY ECYLEALEWCHNLMDAK*" /label="pdeH CDS" gene complement(2909151..2910380) /gene="pdeH" /locus_tag="BSU_31740" /old_locus_tag="BSU31740" /label="pdeH gene" S_feature 2909176..2910489 /Source="Nicolas_S_feature" /locus_tag="new_3258062_3259375" /HighExp="S4, S5, S3, S6, LoTm, S8, S7, T5.0H, B36, Pyr" /AntisenseName="yuxH" /AntisenseCor="-0.78363066752642896" /AntisenseRegPval="-56.4" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1218" promotor_-10 complement(2910415..2910434) /Source="Nicolas_upshift_promotors" /id="U2473" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.795204795204795" /psig="0.999000999001" /xcortree=2206 /SigmaFactorBS="cgaagggccagttttctttatgtatatattatttttcaTGTT TAGAcaattttcgtcaaaTTATTTGATATACTTAGGGGtgaaagccgcgcgtattgta a" /listShort="yuxH, S1217" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2910434) /Source="Nicolas_upshifts" /id="U2473" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.795204795204795" /psig="0.999000999001" /xcortree=2206 /SigmaFactorBS="cgaagggccagttttctttatgtatatattatttttcaTGTT TAGAcaattttcgtcaaaTTATTTGATATACTTAGGGGtgaaagccgcgcgtattgta a" /listShort="yuxH, S1217" /GFF_Attribute="listLong" /label="upshifts" downshifts 2910447 /Source="Nicolas_upshifts" /id="D1641" /incds=0 /nref=6 /ntot=30 /MaxReadThrough="1.76106" /MaxDrop="4.58543" /score="22.3133759" /energy="-13.3" /TU="NA" /idTUdmin="U2472" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 complement(2910449..2910456) /Source="Nicolas_upshift_promotors" /id="U2473" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.795204795204795" /psig="0.999000999001" /xcortree=2206 /SigmaFactorBS="cgaagggccagttttctttatgtatatattatttttcaTGTT TAGAcaattttcgtcaaaTTATTTGATATACTTAGGGGtgaaagccgcgcgtattgta a" /listShort="yuxH, S1217" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2910517..2911989) /gene="pncB" /locus_tag="BSU_31750" /old_locus_tag="BSU31750" /EC_number="6.3.4.21" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 4296374, 12682299, 16199587, 24564896; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nicotinate phosphoribosyltransferase" /protein_id="NP_391053.1" /db_xref="EnsemblGenomes-Gn:BSU31750" /db_xref="EnsemblGenomes-Tr:CAB15163" /db_xref="GOA:O32090" /db_xref="InterPro:IPR006405" /db_xref="InterPro:IPR007229" /db_xref="InterPro:IPR036068" /db_xref="SubtiList:BG13966" /db_xref="UniProtKB/Swiss-Prot:O32090" /translation="MLEYGFKDDSLSLHTDLYQINMAETYWRDGIHEKKAIFELFFRR LPFENGYAVFAGLEKAIEYLENFKFTDSDLSYLQDELGYHEDFIEYLRGLSFTGSLYS MKEGELVFNNEPIMRVEAPLVEAQLIETALLNIVNYQTLIATKAARIKGVIGDEVALE FGTRRAHEMDAAMWGARAALIGGFSATSNVRAGKRFNIPVSGTHAHALVQAYRDEYTA FKKYAETHKDCVFLVDTYDTLRSGMPNAIRVAKEFGDRINFIGIRLDSGDLAYLSKKA RKMLDEAGFTDAKVIASSDLDEHTIMNLKAQGARIDVWGVGTKLITAYDQPALGAVYK LVAIEEDGKMVDTIKISSNPEKVTTPGRKKVYRIINQSNHHSEGDYIALYDEQVNDQK RLRMFHPVHTFISKFVTNFYAKDLHELIFEKGILCYQNPEISDIQQYVQDNLSLLWEE YKRISKPEEYPVDLSEDCWSNKMQRIHEVKSRIEEELEEE*" /label="pncB CDS" gene complement(2910517..2911989) /gene="pncB" /locus_tag="BSU_31750" /old_locus_tag="BSU31750" /label="pncB gene" downshifts complement(2910527) /Source="Nicolas_upshifts" /id="D1642" /incds=0 /nref=200 /ntot=267 /MaxReadThrough="4.08676" /MaxDrop="6.72747" /score="16.2382739" /energy="-14.5" /TU="NA" /idTUdmin="U2475" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" misc_feature 2911870..2911874 /Source="Nicolas_upshift_promotors" /id="U2474" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.992007992007992" /psig="0.000999000999001" /xcortree=45 /SigmaFactorBS="tccaagcccgcaaatacggcatagccattttcaaacggaagc cttctgaaaaaCAGCTcaaaaatcgctttcttttcatgaatgccgtctctccagtacg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2911877 /Source="Nicolas_upshifts" /id="U2474" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.992007992007992" /psig="0.000999000999001" /xcortree=45 /SigmaFactorBS="tccaagcccgcaaatacggcatagccattttcaaacggaagc cttctgaaaaaCAGCTcaaaaatcgctttcttttcatgaatgccgtctctccagtacg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2911987 /Source="Nicolas_upshifts" /id="D1643" /incds=0 /nref=1 /ntot=123 /MaxReadThrough="1.2059" /MaxDrop="3.08208" /score="22.3133759" /energy="-13.3" /TU="NA" /idTUdmin="U2472" /TUdmin=1540 /isTUend="FALSE" /label="downshifts" CDS complement(2912005..2912556) /gene="pncA" /locus_tag="BSU_31760" /old_locus_tag="BSU31760" /EC_number="3.5.1.19" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15135535, 17382284, 18616465, 24340054, 24512664; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nicotinamidase; NAD salvage pathway" /protein_id="NP_391054.1" /db_xref="EnsemblGenomes-Gn:BSU31760" /db_xref="EnsemblGenomes-Tr:CAB15164" /db_xref="GOA:O32091" /db_xref="InterPro:IPR000868" /db_xref="InterPro:IPR036380" /db_xref="SubtiList:BG13965" /db_xref="UniProtKB/Swiss-Prot:O32091" /translation="MKKALICIDYTNDFVASDGKLTCGEPGRMIEEAIVNLTKEFITN GDYVVLAVDSHDEGDQYHPETRLFPPHNIKGTEGKDLYGKLLPLYQKHEHEPNVYYME KTRYSAFAGTDLELKLRERQIGELHLAGVCTDICVLHTAVDAYNKGFRIVVHKQAVAS FNQEGHAWALSHFANSIGAQVAE*" /label="pncA CDS" gene complement(2912005..2912556) /gene="pncA" /locus_tag="BSU_31760" /old_locus_tag="BSU31760" /label="pncA gene" promotor_-10 complement(2912578..2912597) /Source="Nicolas_upshift_promotors" /id="U2475" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.668331668331668" /psig=1 /xcortree=2232 /SigmaFactorBS="agacaaacggaccgtttgtctttttgttcatggcAATTCACT tacaactggagaTAAGATATAATGTTCTCATActgatggcggggaggccggctatgaa a" /listShort="pncA, pncB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2912591) /Source="Nicolas_upshifts" /id="U2475" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.668331668331668" /psig=1 /xcortree=2232 /SigmaFactorBS="agacaaacggaccgtttgtctttttgttcatggcAATTCACT tacaactggagaTAAGATATAATGTTCTCATActgatggcggggaggccggctatgaa a" /listShort="pncA, pncB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2912610..2912617) /Source="Nicolas_upshift_promotors" /id="U2475" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.668331668331668" /psig=1 /xcortree=2232 /SigmaFactorBS="agacaaacggaccgtttgtctttttgttcatggcAATTCACT tacaactggagaTAAGATATAATGTTCTCATActgatggcggggaggccggctatgaa a" /listShort="pncA, pncB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2912653..2913051) /gene="yueI" /locus_tag="BSU_31770" /old_locus_tag="BSU31770" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391055.1" /db_xref="EnsemblGenomes-Gn:BSU31770" /db_xref="EnsemblGenomes-Tr:CAB15165" /db_xref="InterPro:IPR012543" /db_xref="InterPro:IPR029064" /db_xref="PDB:2OHW" /db_xref="SubtiList:BG13964" /db_xref="UniProtKB/Swiss-Prot:O32092" /translation="MSEDKMDLYLQQGMYGPLETKPDERHLFLGSLRERVVLALTKGQ VLRSKPYKEAEHELKNSHNVTLLINGELQYQSYSSYIQMASRYGVPFKIVSDLQFHTP LGIVIAADIAVNRELIYIQDDIYNRSVLKS*" /label="yueI CDS" gene complement(2912653..2913051) /gene="yueI" /locus_tag="BSU_31770" /old_locus_tag="BSU31770" /label="yueI gene" S_feature complement(2913052..2913122) /Source="Nicolas_S_feature" /locus_tag="new_3261938_3262008_c" /HighExp="Etha, dia5, Diami, dia15, H2O2, LBGtran, LPhT, G135, G180, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="SigA" /TUlongPSig="0.998" /label="S1219" CDS complement(2913123..2913371) /gene="yueH" /locus_tag="BSU_31780" /old_locus_tag="BSU31780" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391056.1" /db_xref="EnsemblGenomes-Gn:BSU31780" /db_xref="EnsemblGenomes-Tr:CAB15166" /db_xref="InterPro:IPR020260" /db_xref="SubtiList:BG13963" /db_xref="UniProtKB/Swiss-Prot:O32093" /translation="MKIRKANINTQTGMITDVYLHENRKELRTLVAVPQLEWSTIISY EEDKATLPERLEASLRRHTEETPAGELAKKIIHWVTEM*" /label="yueH CDS" gene complement(2913123..2913371) /gene="yueH" /locus_tag="BSU_31780" /old_locus_tag="BSU31780" /label="yueH gene" promotor_-10 complement(2913394..2913413) /Source="Nicolas_upshift_promotors" /id="U2476" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=1994 /SigmaFactorBS="aacagtttcgtttaacgggtaacagccttttcaCAAGaggct gttgctttttTATTGTATAATATGGGTAGTctttgaatagagaggtcatgttatgaaa a" /listShort="yueH, S1219, yueI, pncA, pncB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2913405) /Source="Nicolas_upshifts" /id="U2476" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=1994 /SigmaFactorBS="aacagtttcgtttaacgggtaacagccttttcaCAAGaggct gttgctttttTATTGTATAATATGGGTAGTctttgaatagagaggtcatgttatgaaa a" /listShort="yueH, S1219, yueI, pncA, pncB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2913429..2913432) /Source="Nicolas_upshift_promotors" /id="U2476" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.703296703296703" /psig=1 /xcortree=1994 /SigmaFactorBS="aacagtttcgtttaacgggtaacagccttttcaCAAGaggct gttgctttttTATTGTATAATATGGGTAGTctttgaatagagaggtcatgttatgaaa a" /listShort="yueH, S1219, yueI, pncA, pncB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2913444..2913665) /gene="yueG" /locus_tag="BSU_31790" /old_locus_tag="BSU31790" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative spore germination protein" /protein_id="NP_391057.1" /db_xref="EnsemblGenomes-Gn:BSU31790" /db_xref="EnsemblGenomes-Tr:CAB15167" /db_xref="InterPro:IPR019618" /db_xref="SubtiList:BG13962" /db_xref="UniProtKB/Swiss-Prot:O32094" /translation="MPAIVGPIYIMSVTDNAAASFGDVFAISPKSVAHSGAGSGTFQL GDFVKINNQTSKTLFKDADITDETVSFNG*" /label="yueG CDS" gene complement(2913444..2913665) /gene="yueG" /locus_tag="BSU_31790" /old_locus_tag="BSU31790" /label="yueG gene" downshifts complement(2913471) /Source="Nicolas_upshifts" /id="D1644" /incds=0 /nref=11 /ntot=31 /MaxReadThrough="3.65047" /MaxDrop="4.3681" /score="19.032155" /energy="-12.6" /TU="U2477,U2479,U2482" /idTUdmin="U2482" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" downshifts 2913659 /Source="Nicolas_upshifts" /id="D1645" /incds=0 /nref=1 /ntot=3 /MaxReadThrough="1.17049" /MaxDrop="3.0193" /score="-7.47675224" /energy="-6.7" /TU="NA" /idTUdmin="U2480" /TUdmin="-1320" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2913683..2913702) /Source="Nicolas_upshift_promotors" /id="U2477" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1310 /SigmaFactorBS="ggaaaacgcaaagccagctgaatagGCGGGCACCAttatcgg ctcctTGCATATGATGCTGTAAATCaatgcggaggtggggaaatgcctgcaattgtgg g" /listShort="yueG, yueH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2913689) /Source="Nicolas_upshifts" /id="U2477" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1310 /SigmaFactorBS="ggaaaacgcaaagccagctgaatagGCGGGCACCAttatcgg ctcctTGCATATGATGCTGTAAATCaatgcggaggtggggaaatgcctgcaattgtgg g" /listShort="yueG, yueH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2913715..2913724) /Source="Nicolas_upshift_promotors" /id="U2477" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1310 /SigmaFactorBS="ggaaaacgcaaagccagctgaatagGCGGGCACCAttatcgg ctcctTGCATATGATGCTGTAAATCaatgcggaggtggggaaatgcctgcaattgtgg g" /listShort="yueG, yueH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2913725..2914834) /gene="yueF" /locus_tag="BSU_31800" /old_locus_tag="BSU31800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10960106, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391058.1" /db_xref="EnsemblGenomes-Gn:BSU31800" /db_xref="EnsemblGenomes-Tr:CAB15168" /db_xref="GOA:O32095" /db_xref="InterPro:IPR002549" /db_xref="SubtiList:BG13961" /db_xref="UniProtKB/Swiss-Prot:O32095" /translation="MLKSKVHFWTLQILFVLLIIFVATKVSFVFQPFIVFISTLFFPM LIAGILYFIFNPVVRLLEKKIPRTLSILLIYLLFIGLLAFISASVGPIITAQVTGLFN NLPDYIKQIQALTKDLSHSQWFTWMMNQDYVSISKIEQSLTSFLQNLPQNITSSLSAV FGVVTNITLVIITVPFILFYMLKDGHRFPHLAVKILPASYRTEGLKIFKDLSDTLAAY FQGQLLICLFVGTACFIGYLIAGLPYALILGIVMAITNIIPYVGPFLGAAPAVIVGFM DSPAKALFAIIVVVIVQQLDGNLLSPLVIGKRLNTHPLTIILLLIGAGSFGGILGMIL AVPVYAVVKAFFLNIVRLIKLRQRSRLEENAKPAE*" /label="yueF CDS" gene complement(2913725..2914834) /gene="yueF" /locus_tag="BSU_31800" /old_locus_tag="BSU31800" /label="yueF gene" promotor_-35 2914486..2914493 /Source="Nicolas_upshift_promotors" /id="U2478" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2030 /SigmaFactorBS="ccaggtaaaccattgagaatgggacaaatCCTTTGTCagcgc ctgaatctgTTTTATATAATCAGGAAGGTtgttaaacagccctgtcacctgtgcggtg a" /listShort="S1220, yuzE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2914508..2914527 /Source="Nicolas_upshift_promotors" /id="U2478" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2030 /SigmaFactorBS="ccaggtaaaccattgagaatgggacaaatCCTTTGTCagcgc ctgaatctgTTTTATATAATCAGGAAGGTtgttaaacagccctgtcacctgtgcggtg a" /listShort="S1220, yuzE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2914517..2914911 /Source="Nicolas_S_feature" /locus_tag="new_3263403_3263797" /HighExp="dia15, S8, H2O2, dia5, LBGstat, Paraq, C30, S7, Diami, G180" /AntisenseName="yueF" /AntisenseCor="0.28555063485711402" /AntisenseRegPval="-5.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1220" upshifts 2914517 /Source="Nicolas_upshifts" /id="U2478" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=2030 /SigmaFactorBS="ccaggtaaaccattgagaatgggacaaatCCTTTGTCagcgc ctgaatctgTTTTATATAATCAGGAAGGTtgttaaacagccctgtcacctgtgcggtg a" /listShort="S1220, yuzE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2914882..2914901) /Source="Nicolas_upshift_promotors" /id="U2479" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.380619380619381" /psig="0.999000999001" /xcortree=2209 /SigmaFactorBS="cggccttcatcaccaacactcctttcattatattaagaGTTC TGatatgagttcattTTTGTTACAATGATGGGGTAtaagttcttttatctgacagaca a" /listShort="yueF, yueG, yueH, S1219, yueI" /listLong="pncA, pncB" /label="promotor_-10" upshifts complement(2914898) /Source="Nicolas_upshifts" /id="U2479" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.380619380619381" /psig="0.999000999001" /xcortree=2209 /SigmaFactorBS="cggccttcatcaccaacactcctttcattatattaagaGTTC TGatatgagttcattTTTGTTACAATGATGGGGTAtaagttcttttatctgacagaca a" /listShort="yueF, yueG, yueH, S1219, yueI" /listLong="pncA, pncB" /label="upshifts" S_feature complement(2914900..2915340) /Source="Nicolas_S_feature" /locus_tag="new_3263786_3264226_c" /HighExp="Diami, S8, H2O2, S7, C90, Paraq, Salt, S1, dia15, dia5" /AntisenseName="yuzE" /AntisenseCor="0.47136608606324898" /AntisenseRegPval="-15.6" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1221" promotor_-35 2914903..2914905 /Source="Nicolas_upshift_promotors" /id="U2480" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.657342657342657" /psig="0.657342657342657" /xcortree=1364 /SigmaFactorBS="tttctttgtctgtcagataaaagaacttataccccatcattg taacaaaaATGaactcatatcagaacTCTTAATATAATGAAAGGAGtgttggtgatga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2914913 /Source="Nicolas_upshifts" /id="U2480" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.657342657342657" /psig="0.657342657342657" /xcortree=1364 /SigmaFactorBS="tttctttgtctgtcagataaaagaacttataccccatcattg taacaaaaATGaactcatatcagaacTCTTAATATAATGAAAGGAGtgttggtgatga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2914915..2914920) /Source="Nicolas_upshift_promotors" /id="U2479" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.380619380619381" /psig="0.999000999001" /xcortree=2209 /SigmaFactorBS="cggccttcatcaccaacactcctttcattatattaagaGTTC TGatatgagttcattTTTGTTACAATGATGGGGTAtaagttcttttatctgacagaca a" /listShort="yueF, yueG, yueH, S1219, yueI" /listLong="pncA, pncB" /label="promotor_-35" promotor_-10 2914921..2914940 /Source="Nicolas_upshift_promotors" /id="U2480" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.657342657342657" /psig="0.657342657342657" /xcortree=1364 /SigmaFactorBS="tttctttgtctgtcagataaaagaacttataccccatcattg taacaaaaATGaactcatatcagaacTCTTAATATAATGAAAGGAGtgttggtgatga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2914949..2915338 /gene="yuzE" /locus_tag="BSU_31810" /old_locus_tag="BSU31810" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391059.1" /db_xref="EnsemblGenomes-Gn:BSU31810" /db_xref="EnsemblGenomes-Tr:CAB15169" /db_xref="InterPro:IPR016789" /db_xref="InterPro:IPR019270" /db_xref="SubtiList:BG14054" /db_xref="UniProtKB/Swiss-Prot:O32096" /translation="MKAVTYDTDSELAYIYVLPPKKNRNVRTEELRVNDCLLLDISQD GKIAGFECFGEAAHLCAPFAGKSRLYVKDSDGYHFRVCQHASVRSCYTVYRVTFCFSD GDYQEFAGFDLDGTMYHSAFLQRLTEK*" /label="yuzE CDS" gene 2914949..2915338 /gene="yuzE" /locus_tag="BSU_31810" /old_locus_tag="BSU31810" /label="yuzE gene" CDS complement(2915379..2915615) /gene="yuzF" /locus_tag="BSU_31820" /old_locus_tag="BSU31820" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391060.1" /db_xref="EnsemblGenomes-Gn:BSU31820" /db_xref="EnsemblGenomes-Tr:CAB15170" /db_xref="InterPro:IPR020139" /db_xref="SubtiList:BG14055" /db_xref="UniProtKB/Swiss-Prot:O32097" /translation="MVNQGSPQLVSLVDPYVYQTIKKLIGSRFVIQTVRDTVRGRLID VKPDHITIEGARNSVCLIRIQHMISVTPDYSERV*" /label="yuzF CDS" gene complement(2915379..2915615) /gene="yuzF" /locus_tag="BSU_31820" /old_locus_tag="BSU31820" /label="yuzF gene" downshifts complement(2915385) /Source="Nicolas_upshifts" /id="D1646" /incds=0 /nref=12 /ntot=37 /MaxReadThrough="5.19136" /MaxDrop="5.1675" /score="30.7642328" /energy="-9.9" /TU="U2482" /idTUdmin="U2481" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2915635..2915654) /Source="Nicolas_upshift_promotors" /id="U2481" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1324 /SigmaFactorBS="aatctccgcacccctttgttttatcaggtaagCCTGTGTCAT tatccataagcgcGGCATAAGCTGAGATAAAACacacaaaggggataaaagtatggtc a" /listShort="yuzF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2915649) /Source="Nicolas_upshifts" /id="U2481" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1324 /SigmaFactorBS="aatctccgcacccctttgttttatcaggtaagCCTGTGTCAT tatccataagcgcGGCATAAGCTGAGATAAAACacacaaaggggataaaagtatggtc a" /listShort="yuzF" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2915651..2915791) /Source="Nicolas_S_feature" /locus_tag="new_3264537_3264677_c" /HighExp="BT, Diami, S8, Etha, Sw, C90, Salt, B36, LPhT, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.998, 0.989" /TUlongSig="NA" /TUlongPSig="NA" /label="S1222" promotor_-35 complement(2915668..2915677) /Source="Nicolas_upshift_promotors" /id="U2481" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1324 /SigmaFactorBS="aatctccgcacccctttgttttatcaggtaagCCTGTGTCAT tatccataagcgcGGCATAAGCTGAGATAAAACacacaaaggggataaaagtatggtc a" /listShort="yuzF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2915792..2916322) /gene="yueE" /locus_tag="BSU_31830" /old_locus_tag="BSU31830" /EC_number="3.-.-.-" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent phosphohydrolase" /protein_id="NP_391061.1" /db_xref="EnsemblGenomes-Gn:BSU31830" /db_xref="EnsemblGenomes-Tr:CAB15171" /db_xref="GOA:O32098" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR006674" /db_xref="InterPro:IPR006675" /db_xref="SubtiList:BG13960" /db_xref="UniProtKB/Swiss-Prot:O32098" /translation="MRKVTLMDVFTHPIAQKYLQRSGVAHAIACAYHAYRLSVKADIN PDLAAKAALLHDIGHYEWYTDGKWDYEKYKRNDIHAIKGAERAHKLLIRLGEEPKAAK EIALAILLHTDSYLPEGELDKNTLQQIVKKADELDEEPGGHHHYRQIDPSTARKKIEK LDQLIDQAQASVIKPV*" /label="yueE CDS" gene complement(2915792..2916322) /gene="yueE" /locus_tag="BSU_31830" /old_locus_tag="BSU31830" /label="yueE gene" promotor_-10 complement(2916342..2916361) /Source="Nicolas_upshift_promotors" /id="U2482" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.494505494505495" /psig="0.998001998001998" /xcortree=636 /SigmaFactorBS="atgataagaagatcaaaatgatgtgacataagAATTGAGTTt ctctgcaaatTATGTTAGGATTCTAAAAATatctaaaggaggggtttccatgagaaag g" /listShort="yueE, S1222, yuzF, S1221, yueF, yueG" /listLong="yueH, S1219, yueI, pncA, pncB" /label="promotor_-10" upshifts complement(2916353) /Source="Nicolas_upshifts" /id="U2482" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.494505494505495" /psig="0.998001998001998" /xcortree=636 /SigmaFactorBS="atgataagaagatcaaaatgatgtgacataagAATTGAGTTt ctctgcaaatTATGTTAGGATTCTAAAAATatctaaaggaggggtttccatgagaaag g" /listShort="yueE, S1222, yuzF, S1221, yueF, yueG" /listLong="yueH, S1219, yueI, pncA, pncB" /label="upshifts" S_feature complement(2916355..2916441) /Source="Nicolas_S_feature" /locus_tag="new_3265241_3265327_c" /HighExp="BT, S8, S6, S7, B36, Etha, S5, S4, Pyr, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.989" /TUlongSig="NA" /TUlongPSig="NA" /label="S1223" promotor_-35 complement(2916373..2916381) /Source="Nicolas_upshift_promotors" /id="U2482" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.494505494505495" /psig="0.998001998001998" /xcortree=636 /SigmaFactorBS="atgataagaagatcaaaatgatgtgacataagAATTGAGTTt ctctgcaaatTATGTTAGGATTCTAAAAATatctaaaggaggggtttccatgagaaag g" /listShort="yueE, S1222, yuzF, S1221, yueF, yueG" /listLong="yueH, S1219, yueI, pncA, pncB" /label="promotor_-35" promotor_-10 complement(2916436..2916455) /Source="Nicolas_upshift_promotors" /id="U2483" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=730 /SigmaFactorBS="tcttttttttatacaaaaggctgcaGCCAGCGCATtttattg aacagcCGCATATACTGACTGAAACGttgcttttagggtataacaatgatgataagaa g" /listShort="S1223, yueE, S1222, yuzF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2916443) /Source="Nicolas_upshifts" /id="U2483" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=730 /SigmaFactorBS="tcttttttttatacaaaaggctgcaGCCAGCGCATtttattg aacagcCGCATATACTGACTGAAACGttgcttttagggtataacaatgatgataagaa g" /listShort="S1223, yueE, S1222, yuzF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2916469..2916478) /Source="Nicolas_upshift_promotors" /id="U2483" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=730 /SigmaFactorBS="tcttttttttatacaaaaggctgcaGCCAGCGCATtttattg aacagcCGCATATACTGACTGAAACGttgcttttagggtataacaatgatgataagaa g" /listShort="S1223, yueE, S1222, yuzF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2916520..2917251) /gene="bznD" /locus_tag="BSU_31840" /old_locus_tag="BSU31840" /EC_number="1.1.1.320" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11745140, 21670841; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="benzil reductase (benzoin forming)" /protein_id="NP_391062.1" /db_xref="EnsemblGenomes-Gn:BSU31840" /db_xref="EnsemblGenomes-Tr:CAB15172" /db_xref="GOA:O32099" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG13959" /db_xref="UniProtKB/Swiss-Prot:O32099" /translation="MELYIITGASKGLGQAIALQALEKGHEVHALSRTKTDVSHKKLT QHQIDLINLEEAEQQFETLLSSIDSDRYSGITLINNAGMVTPIKRAGEASLDELQRHY QLNLTAPVLLSQLFTKRFASYSGKKTVVNITSGAAKNPYKGWSAYCSSKAGLDMFTRT FGFEQEDEELPVNMISFSPGVMDTEMQAVIRSSSKKDFHHIERFRKLNETGSLRSPDF IAGTLLSLLEKGTENGRIYDIKEFL*" /label="bznD CDS" gene complement(2916520..2917251) /gene="bznD" /locus_tag="BSU_31840" /old_locus_tag="BSU31840" /label="bznD gene" downshifts complement(2916550) /Source="Nicolas_upshifts" /id="D1647" /incds=0 /nref=183 /ntot=253 /MaxReadThrough="2.76356" /MaxDrop="5.18507" /score="30.7642328" /energy="-9.9" /TU="NA" /idTUdmin="U2484" /TUdmin="-21" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2917266..2917285) /Source="Nicolas_upshift_promotors" /id="U2484" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.996003996003996" /psig=1 /xcortree=2058 /SigmaFactorBS="gcgcaggaaaacaagaaggcgtaggccgcgTGCTTGTGttgt gtaaaagaggTGCCGTACAATAATAACGGAaaaggaggtttccaatggaactttatat c" /listShort="yueD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2917277) /Source="Nicolas_upshifts" /id="U2484" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.996003996003996" /psig=1 /xcortree=2058 /SigmaFactorBS="gcgcaggaaaacaagaaggcgtaggccgcgTGCTTGTGttgt gtaaaagaggTGCCGTACAATAATAACGGAaaaggaggtttccaatggaactttatat c" /listShort="yueD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2917300..2917307) /Source="Nicolas_upshift_promotors" /id="U2484" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.996003996003996" /psig=1 /xcortree=2058 /SigmaFactorBS="gcgcaggaaaacaagaaggcgtaggccgcgTGCTTGTGttgt gtaaaagaggTGCCGTACAATAATAACGGAaaaggaggtttccaatggaactttatat c" /listShort="yueD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2917314..2917769) /gene="yueC" /locus_tag="BSU_31850" /old_locus_tag="BSU31850" /function="11.1: Protein and peptide secretion and trafficking" /experiment="publication(s) with functional evidences, PMID:15576783, 24798022" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15576783, 24798022; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ESX secretion system YueC protein" /protein_id="NP_391063.1" /db_xref="EnsemblGenomes-Gn:BSU31850" /db_xref="EnsemblGenomes-Tr:CAB15173" /db_xref="GOA:O32100" /db_xref="InterPro:IPR018920" /db_xref="InterPro:IPR020212" /db_xref="SubtiList:BG13958" /db_xref="UniProtKB/Swiss-Prot:O32100" /translation="MLSFSLFIPSAAAAQTEENTDVAPNQYEKKDIEIDTNYLHEDTY YEEKTELPEEQKDITFDKPKDKDAELIKDLFTSTNAEDSNTIAAQSKQLGITFAEKPM TKTSSTETEDEQETSSLLLPMIYVVLILLGIAGIVFLIPKVTAQENKKA*" /label="yueC CDS" gene complement(2917314..2917769) /gene="yueC" /locus_tag="BSU_31850" /old_locus_tag="BSU31850" /label="yueC gene" promotor_-35 2917722..2917728 /Source="Nicolas_upshift_promotors" /id="U2485" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=235 /SigmaFactorBS="actggtttggcgcgacatctgtattttcttcAGTTTGGgcag ccgctgcagaGGGTATGAAAAGGGAAAAGgagagcatacaaatcatgatccccttttc c" /listShort="S1224" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2917743..2917761 /Source="Nicolas_upshift_promotors" /id="U2485" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=235 /SigmaFactorBS="actggtttggcgcgacatctgtattttcttcAGTTTGGgcag ccgctgcagaGGGTATGAAAAGGGAAAAGgagagcatacaaatcatgatccccttttc c" /listShort="S1224" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2917751..2920118 /Source="Nicolas_S_feature" /locus_tag="new_3266637_3269004" /HighExp="Etha, Gly, Sw, Salt, LoTm, C30, BT, HiTm, Mal, G135" /AntisenseName="yueB" /AntisenseCor="-9.3455707286730305E-2" /AntisenseRegPval="-0.9" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1224" upshifts 2917751 /Source="Nicolas_upshifts" /id="U2485" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=235 /SigmaFactorBS="actggtttggcgcgacatctgtattttcttcAGTTTGGgcag ccgctgcagaGGGTATGAAAAGGGAAAAGgagagcatacaaatcatgatccccttttc c" /listShort="S1224" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2917801..2921031) /gene="yueB" /locus_tag="BSU_31860" /old_locus_tag="BSU31860" /function="11.1: Protein and peptide secretion and trafficking" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15576783, 24798022, 27179995" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15576783, 24798022, 27179995; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ESX secretion system; calcium-dependent phage SPP1 attachment site" /protein_id="NP_391064.1" /db_xref="EnsemblGenomes-Gn:BSU31860" /db_xref="EnsemblGenomes-Tr:CAB15174" /db_xref="GOA:O32101" /db_xref="InterPro:IPR023838" /db_xref="SubtiList:BG13957" /db_xref="UniProtKB/Swiss-Prot:O32101" /translation="MTEQRKSLIKLISAVIIILLLPVLFFRFIGDDPTKKAVNSTRQI AVVNEDTGVLSDEVKSDEEDKSAQFGKEVAAVLGERPDYSWTVVNRSAAETGLASKKY DAIVYIPSDFSKNILSYDKDHPQKATLEFSIQDNLNAVNKEKVQRELEDAQKTMNKKM SALYWNFVSQKVDNIRGEFDKIVNKESEFQNVMYNFYKPSSNDLAGEIKQQKDLIDEL KKSMNEAQGTTKEKASTAEEAKNTLKEFIDTVERYKEYQENQKKLLLAAQDSTQQQIR TGLDAIQAQQKANQFSERMSGLATGIGQAKTQIGLTNLALNNAEKLRQNQVPLQEMGM KKIENDMFNAFLSRYKSQYEAIKYQNLNQLQENIGKNRLSLLKPKESDEKEDGEDTSD NKDDTDKEDIEDIKLDLEKQRDELKNVATEIKDISEGLKEPEQEKPTTPDAEEPSTDD SPNTEEPSNDIPTSDDQPTNEDTGSSEEGTQDNGSQNDVQTNIETGQKHQESSKNVPE QDTNTENTGTSKTDFSLIELADENDGSNQSDGLQGDGADGETDISGAKKRLNEAAIKL EEIENALQEKQEEHNNKLEKHIDELNQEIKELNKTVSKLNDQIGDLTKKLVDFDNNVN DAYRLIYNLEDEIIQTLQSRGYIDQKEKLSSIFSSRIETDNISNLMKYYNSLNLYKST LNDNLDLGSLTIIKGEVIQEQDGNVQSVLALTPEESASWEALKNNTMQTDEDINSFID GMTKFADDYSGYIRDSQAGVLDELTKISESAAKASEQLVTGATQESATFSNDGLSGTM ALSVQDTVGQEVLQMSDMMGSLSDRQSGIIDYTTNMQQSVNDVQAKADTLNNNWGKNV ASTKLVRNDVYGILGNTLVDGQNNGYVYDYLANPLKISGEVPEEKIQTVPPVVILVIV LISSLLIGYFSSYYQNAPLLVKGALFGILNILVGLMISLFGLNIYSLPDDQTIKWSVF TILLLVASSAFIRTAFRFGSIPGWVASAAMILFYVAPLIDLIMPNFTFEDPVSKVYID IQYGTGHLFTMGITVLLIITVIAVALPLIIRLMAEHTAESDETYEA*" /label="yueB CDS" gene complement(2917801..2921031) /gene="yueB" /locus_tag="BSU_31860" /old_locus_tag="BSU31860" /label="yueB gene" CDS complement(2921028..2925515) /gene="yukAB" /locus_tag="BSU_31875" /old_locus_tag="BSU31875" /function="11.1: Protein and peptide secretion and trafficking" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15576783, 24798022" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15576783, 24798022; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ESX secretion system FtsK/SpoIIIE family ATPase" /protein_id="NP_391066.2" /db_xref="EnsemblGenomes-Gn:BSU31875" /db_xref="EnsemblGenomes-Tr:CAB15176" /db_xref="GOA:C0SPA7" /db_xref="InterPro:IPR002543" /db_xref="InterPro:IPR022206" /db_xref="InterPro:IPR023839" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12375" /db_xref="UniProtKB/Swiss-Prot:C0SPA7" /translation="MSLLWVFYQNNVQKLNLSNLPSSHPVTIGPDVKDSVTISTIPFN SGVISLKRKESGGQYEVFLGNDCLGTIETDISFTLQTDQQDIRLILTGSEPEKSVYFT GNRDEIVCSSEKTNADIYLNPQDFAFAEQSTFSLLRAGGSWSVRPESGTIFLNGEKIN ANTPLKPGDEIFWNFTQMRVTEQDLLEIVHYAQFETALTETVKPSTEMQKKYPQYRRT PRMVYDLPDDRVSFSFPSQESDQTNRGLWLVILPPLVMLIVMGVVAIIQPRGIFILVS LAMFMMTLITSTVQYFRDKNQRKKREEKRERVYKLYLDNKRKELQALAEKQKQVLEFH FPSFEQMKYLTSEISDRIWEKSLESKDYLQLRLGTGTVPSSYEINMSGGDLANRDIDD LMEKSQHMQRVYKDIRNAPVTVDLAEGPMGLVGKSQIVKNEIHQLIGQLSFFNSYHDL RFVFIFHEEEYKDWEWMKWLPQFQMPHIYAKGFIYNEQTRDQLLSSLYELIRERDLED DKEKLQFKPHFVFVITNQQLISEHVILEYLEGQHEHLGISTIVAAETKESLSENITTL VRYINEHEGDILIQKKKAVRIPFRLDHHQREDNERFSRTLRTLNHQVGITNSIPETVS FLELFHAKEVKEIGIQQRWLTSESSKSLSVPIGYKGKDDIVYLNLHEKAHGPHGLLAG TTGSGKSEFLQTYILSLAVHFHPHEAAFLLIDYKGGGMAQPFRNIPHLLGTITNIEGS KNFSMRALASIKSELKKRQRLFDQYQVNHINDYTKLYKQGKAEVAMPHLFLISDEFAE LKSEEPDFIRELVSAARIGRSLGVHLILATQKPGGIIDDQIWSNSRFKVALKVQDATD SKEILKNSDAANITVTGRGYLQVGNNEVYELFQSAWSGAPYLEEVYGTEDEIAIVTDT GLIPLSEVDTEDNAKKDVQTEIEAVVDEIERIQDEMGIEKLPSPWLPPLAERIPRTLF PSNEKDHFHFAYVDEPDLQRQAPIAYKMMEDGNIGIFGSSGYGKSIAAATFLMSFADV YTPEELHVYIFDFGNGTLLPLAKLPHTADYFLMDQSRKIEKFMIRIKEEIDRRKRLFR EKEISHIKMYNALSEEELPFIFITIDNFDIVKDEMHELESEFVQLSRDGQSLGIYFML TATRVNAVRQSLLNNLKTKIVHYLMDQSEGYSIYGRPKFNLEPIPGRVIIQKEELYFA QMFLPVDADDDIGMFNELKSDVQKLQGRFASMEQPAPIPMLPESLSTRELSIRFKLER KPLSVPIGLHEETVSPVYFDLGKHKHCLILGQTQRGKTNVLKVMLEHLIDDETEMIGL FDSIDRGLSHYAKESDVSYLETKEDIEQWIETAEDIFKTREAMYVEAVRQGDAQNLRF SQVVLMIDGITRFQQTIDTRIQDRLANFMKSYAHLGFSFIPGGNHSEFSKGYDSLTTE MKQIRHAILLMKKSEQNVIPLPYQRQEPEIQPGFGYVVENGKEQKVQIPLCSAERESA R*" /label="yukAB CDS" gene complement(2921028..2925515) /gene="yukAB" /locus_tag="BSU_31875" /old_locus_tag="BSU31875" /label="yukAB gene" promotor_-35 2924790..2924796 /Source="Nicolas_upshift_promotors" /id="U2486" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=203 /SigmaFactorBS="cggaggcaggatgacgagccacagccctctgttGGTTTGAtc gctctcctgagaGGGAAAACTGAAAGAAACGcggtcatccggcagatcgtataccatc c" /listShort="S1225" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2924811..2924829 /Source="Nicolas_upshift_promotors" /id="U2486" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=203 /SigmaFactorBS="cggaggcaggatgacgagccacagccctctgttGGTTTGAtc gctctcctgagaGGGAAAACTGAAAGAAACGcggtcatccggcagatcgtataccatc c" /listShort="S1225" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2924817..2925779 /Source="Nicolas_S_feature" /locus_tag="new_3273703_3274665" /HighExp="Etha, Sw, Gly, Salt, B60, M9-stat, LoTm, T0.30H, BT, LPhT" /AntisenseName="yukB" /AntisenseCor="-0.26212584196591598" /AntisenseRegPval="-4.9000000000000004" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1225" upshifts 2924817 /Source="Nicolas_upshifts" /id="U2486" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=203 /SigmaFactorBS="cggaggcaggatgacgagccacagccctctgttGGTTTGAtc gctctcctgagaGGGAAAACTGAAAGAAACGcggtcatccggcagatcgtataccatc c" /listShort="S1225" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2925576..2926931) /gene="yukC" /locus_tag="BSU_31890" /old_locus_tag="BSU31890" /function="11.1: Protein and peptide secretion and trafficking" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15576783, 16845009, 24798022" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15576783, 16845009, 24798022; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ESX secretion system YukC protein" /protein_id="NP_391067.1" /db_xref="EnsemblGenomes-Gn:BSU31890" /db_xref="EnsemblGenomes-Tr:CAB15177" /db_xref="GOA:P71070" /db_xref="InterPro:IPR018778" /db_xref="SubtiList:BG12376" /db_xref="UniProtKB/Swiss-Prot:P71070" /translation="MSGEQKSYLENQLEAVAEKTDAGYTFTFQREKIKLLDGLEANVI KDINPFFHKEIDVTDDEVIITIQPPSSYKAFRFMKAKDKKSKWQFAYQLVQAVQQHNL SRLNLIVAPENIVFDKGLTPYFLHYGVKESIPPYERDEERVWQELKAAAALAVDGAFA FEDYLKFNETLTFSAEAKAILDAESYDDLLELIQTHIDELEAKAKTYIHIPRKKWNIQ RYIGLGLIVLLVPALIYSMYALFFAQPKHQAIVDSNRAFLNKQYSEVISTLSKYDAES LPESVQYQLATSYVEVENLGSAKTKNIENNLVTLQSDPQHFLYWIDYGRGEYKEAISI GRKLEYNDYIYFALAKYKQQLLSEDTNDEDIQKELDSVNSELEKAQKERQENKQSNSE TSLVDTSEEQTQTDEEKQAEEKAAEEKAAAEEKAKKEEQKEKEDEKKETEKKDEKKDD K*" /label="yukC CDS" gene complement(2925576..2926931) /gene="yukC" /locus_tag="BSU_31890" /old_locus_tag="BSU31890" /label="yukC gene" downshifts complement(2925597) /Source="Nicolas_upshifts" /id="D1648" /incds=0 /nref=5 /ntot=116 /MaxReadThrough="6.33518" /MaxDrop="3.1562" /score="14.9475399" /energy="-16" /TU="U2488" /idTUdmin="U2496" /TUdmin=5823 /isTUend="FALSE" /label="downshifts" CDS complement(2926946..2927185) /gene="yukD" /locus_tag="BSU_31900" /old_locus_tag="BSU31900" /function="11.1: Protein and peptide secretion and trafficking" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15576783, 16845009, 24798022" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15576783, 16845009, 24798022; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ESX secretion system YukD protein" /protein_id="NP_391068.1" /db_xref="EnsemblGenomes-Gn:BSU31900" /db_xref="EnsemblGenomes-Tr:CAB15178" /db_xref="InterPro:IPR014921" /db_xref="InterPro:IPR024962" /db_xref="InterPro:IPR029071" /db_xref="PDB:2BPS" /db_xref="SubtiList:BG12377" /db_xref="UniProtKB/Swiss-Prot:P71071" /translation="MYIDITIDLKHYNGSVFDLRLSDYHPVKKVIDIAWQAQSVSMPP REGHWIRVVNKDKVFSGECKLSDCGITNGDRLEIL*" /label="yukD CDS" gene complement(2926946..2927185) /gene="yukD" /locus_tag="BSU_31900" /old_locus_tag="BSU31900" /label="yukD gene" CDS complement(2927255..2927548) /gene="yukE" /locus_tag="BSU_31910" /old_locus_tag="BSU31910" /function="11.1: Protein and peptide secretion and trafficking" /experiment="publication(s) with functional evidences, PMID:11973144, 15576783, 22720735, 24798022, 24828531" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11973144, 15576783, 22720735, 24798022, 24828531; Product type t : transporter" /codon_start=1 /transl_table=11 /product="small WGX100 secreted protein (ESX-dependent secretion)" /protein_id="NP_391069.2" /db_xref="EnsemblGenomes-Gn:BSU31910" /db_xref="EnsemblGenomes-Tr:CAB15179" /db_xref="GOA:C0SP85" /db_xref="InterPro:IPR010310" /db_xref="InterPro:IPR036689" /db_xref="SubtiList:BG12378" /db_xref="UniProtKB/Swiss-Prot:C0SP85" /translation="MAGLIRVTPEELRAMAKQYGVESQEVLNQVDRLNRMISDLKSMW EGASSEAFADQYEQLKPSFIKMSDLLQDVNQQLDQTANTLESTDQDIANQIRG*" /label="yukE CDS" gene complement(2927255..2927548) /gene="yukE" /locus_tag="BSU_31910" /old_locus_tag="BSU31910" /label="yukE gene" downshifts complement(2927265) /Source="Nicolas_upshifts" /id="D1649" /incds=0 /nref=248 /ntot=268 /MaxReadThrough="6.21938" /MaxDrop="7.50121" /score="14.9475399" /energy="-16" /TU="U2488" /idTUdmin="U2496" /TUdmin=4155 /isTUend="FALSE" /label="downshifts" downshifts 2927542 /Source="Nicolas_upshifts" /id="D1650" /incds=0 /nref=1 /ntot=26 /MaxReadThrough="2.85718" /MaxDrop="3.33739" /score="43.0917981" /energy="-17.1" /TU="NA" /idTUdmin="U2487" /TUdmin="-242" /isTUend="FALSE" /label="downshifts" S_feature complement(2927549..2927627) /Source="Nicolas_S_feature" /locus_tag="new_3276435_3276513_c" /HighExp="T-1.10H, T1.0H, T-0.40H, T1.30H, BI, T2.30H, T3.0H, T-2.40H, T2.0H, T-1.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1226" promotor_-35 2927590..2927597 /Source="Nicolas_upshift_promotors" /id="U2487" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.485514485514486" /psig="0.76023976023976" /xcortree=715 /SigmaFactorBS="tattcctcattacctcctgtgccatcagcctaaatatgggct AATTCACTtatttttagaacgtCATTATTATAAAAACAGTttttcggcatagtcaaac a" /listShort="S1227" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2927607..2927626) /Source="Nicolas_upshift_promotors" /id="U2488" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.735264735264735" /psig=1 /xcortree=3086 /SigmaFactorBS="gtaaaccattggactcattttgtaaaattaaaacatattTGT TTGACtatgccgaaaaactGTTTTTATAATAATGACGTTctaaaaataagtgaattag c" /listShort="S1226, yukE, yukD, yukC, yukB, yueB, yueC, yueD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2927608 /Source="Nicolas_upshifts" /id="U2487" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.485514485514486" /psig="0.76023976023976" /xcortree=715 /SigmaFactorBS="tattcctcattacctcctgtgccatcagcctaaatatgggct AATTCACTtatttttagaacgtCATTATTATAAAAACAGTttttcggcatagtcaaac a" /listShort="S1227" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2927612..2927629 /Source="Nicolas_upshift_promotors" /id="U2487" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.485514485514486" /psig="0.76023976023976" /xcortree=715 /SigmaFactorBS="tattcctcattacctcctgtgccatcagcctaaatatgggct AATTCACTtatttttagaacgtCATTATTATAAAAACAGTttttcggcatagtcaaac a" /listShort="S1227" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2927627) /Source="Nicolas_upshifts" /id="U2488" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.735264735264735" /psig=1 /xcortree=3086 /SigmaFactorBS="gtaaaccattggactcattttgtaaaattaaaacatattTGT TTGACtatgccgaaaaactGTTTTTATAATAATGACGTTctaaaaataagtgaattag c" /listShort="S1226, yukE, yukD, yukC, yukB, yueB, yueC, yueD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2927641..2927648) /Source="Nicolas_upshift_promotors" /id="U2488" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.735264735264735" /psig=1 /xcortree=3086 /SigmaFactorBS="gtaaaccattggactcattttgtaaaattaaaacatattTGT TTGACtatgccgaaaaactGTTTTTATAATAATGACGTTctaaaaataagtgaattag c" /listShort="S1226, yukE, yukD, yukC, yukB, yueB, yueC, yueD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2927686..2927691 /Source="Nicolas_upshift_promotors" /id="U2489" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.523476523476524" /psig="0.523476523476524" /xcortree=769 /SigmaFactorBS="taattttacaaaatgagtccaatggtttACCCCGaatcactc aaaaatGACATATACTGTAAAGTAAAtaggtttattttcttaatcttctcttcattct c" /listShort="S1227" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2927706..2927725 /Source="Nicolas_upshift_promotors" /id="U2489" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.523476523476524" /psig="0.523476523476524" /xcortree=769 /SigmaFactorBS="taattttacaaaatgagtccaatggtttACCCCGaatcactc aaaaatGACATATACTGTAAAGTAAAtaggtttattttcttaatcttctcttcattct c" /listShort="S1227" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2927718..2927824 /Source="Nicolas_S_feature" /locus_tag="new_3276604_3276710" /HighExp="S8, C30, S7, S6, Pyr, Glucon, B60, LoTm, C90, M/G" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA" /TUshortPSig="0.523, 0.76" /TUlongSig="NA" /TUlongPSig="NA" /label="S1227" upshifts 2927718 /Source="Nicolas_upshifts" /id="U2489" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.523476523476524" /psig="0.523476523476524" /xcortree=769 /SigmaFactorBS="taattttacaaaatgagtccaatggtttACCCCGaatcactc aaaaatGACATATACTGTAAAGTAAAtaggtttattttcttaatcttctcttcattct c" /listShort="S1227" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2927893..2927899 /Source="Nicolas_upshift_promotors" /id="U2490" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.418581418581419" /psig="0.81918081918082" /xcortree=1909 /SigmaFactorBS="tctttccttaattagtcttgcctccgatgactttcttAGAAG ATtaataggataagcTGTCGTATTATATGAGACATacactgtcctgcaaaaaggcgat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2927913..2927932 /Source="Nicolas_upshift_promotors" /id="U2490" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.418581418581419" /psig="0.81918081918082" /xcortree=1909 /SigmaFactorBS="tctttccttaattagtcttgcctccgatgactttcttAGAAG ATtaataggataagcTGTCGTATTATATGAGACATacactgtcctgcaaaaaggcgat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2927916 /Source="Nicolas_upshifts" /id="U2490" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.418581418581419" /psig="0.81918081918082" /xcortree=1909 /SigmaFactorBS="tctttccttaattagtcttgcctccgatgactttcttAGAAG ATtaataggataagcTGTCGTATTATATGAGACATacactgtcctgcaaaaaggcgat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2928021..2928024 /Source="Nicolas_upshift_promotors" /id="U2491" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.96103896103896" /xcortree=3188 /SigmaFactorBS="atagaacgtttctctcatgaaattgtttttttgcttctgttc tttgttGTTGattttcacaaacaacAACAATCATAATAAAAGGAAggggatgagatgt c" /listShort="yukF" /listLong="ald" /label="promotor_-35" upshifts 2928033 /Source="Nicolas_upshifts" /id="U2491" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.96103896103896" /xcortree=3188 /SigmaFactorBS="atagaacgtttctctcatgaaattgtttttttgcttctgttc tttgttGTTGattttcacaaacaacAACAATCATAATAAAAGGAAggggatgagatgt c" /listShort="yukF" /listLong="ald" /label="upshifts" promotor_-10 complement(2928036..2928055) /Source="Nicolas_upshift_promotors" /id="U2492" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.564435564435564" /psig="0.98901098901099" /xcortree=2439 /SigmaFactorBS="ggcatggtcataaatctccctacttttcgtgcttgatttctC TTTGACAtctcatccccttccTTTTATTATGATTGTTGTTGtttgtgaaaatcaacaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 2928040..2928059 /Source="Nicolas_upshift_promotors" /id="U2491" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.779220779220779" /psig="0.96103896103896" /xcortree=3188 /SigmaFactorBS="atagaacgtttctctcatgaaattgtttttttgcttctgttc tttgttGTTGattttcacaaacaacAACAATCATAATAAAAGGAAggggatgagatgt c" /listShort="yukF" /listLong="ald" /label="promotor_-10" upshifts complement(2928058) /Source="Nicolas_upshifts" /id="U2492" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.564435564435564" /psig="0.98901098901099" /xcortree=2439 /SigmaFactorBS="ggcatggtcataaatctccctacttttcgtgcttgatttctC TTTGACAtctcatccccttccTTTTATTATGATTGTTGTTGtttgtgaaaatcaacaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 2928069..2929337 /gene="adeR" /locus_tag="BSU_31920" /old_locus_tag="BSU31920" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:22797752" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22797752; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional activator (AdeR-alanine)" /protein_id="NP_391070.2" /db_xref="EnsemblGenomes-Gn:BSU31920" /db_xref="EnsemblGenomes-Tr:CAB15180" /db_xref="GOA:P71073" /db_xref="InterPro:IPR010312" /db_xref="InterPro:IPR025736" /db_xref="InterPro:IPR029016" /db_xref="SubtiList:BG12379" /db_xref="UniProtKB/Swiss-Prot:P71073" /translation="MSKRNQARKVGRFMTMPNDPFKYSFDRLEDVADHISDVLRCPIT IEDVNHKLLAYSTHSDCTDPARTSTIIGRRVPEKVINKLWKDGTIPALLKTDQPIRVK QIDEVGLSNRVAISIWKNKQVLGFIWALEIQKTLSDEDLLTLQMAAKAVKNKLLKLQI RKTKNEERSQEFFWKMLTGHIHQEDDMADGFHKLGMAAPSEFSVMIIRINGELTEKIE QQLQYLQETTQQVYVLLATVDSNELIILTSPKTDHPFQDLKQFALSTQKQLKERYKIE DVSIAFGGIYNSISFVSRSYQEALSVLKTKERFAEETKHLFSFSELGIYQYLDVLNEK RKQAGHYNYSLSKLEQYDRDHQSNMVETLERFIEADSNVNTASKLLNIHVNTLNYRLK RISQIAEIDLKNVNQKFTIYLDIKLRHMDL*" /label="adeR CDS" gene 2928069..2929337 /gene="adeR" /locus_tag="BSU_31920" /old_locus_tag="BSU31920" /label="adeR gene" promotor_-35 complement(2928070..2928077) /Source="Nicolas_upshift_promotors" /id="U2492" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.564435564435564" /psig="0.98901098901099" /xcortree=2439 /SigmaFactorBS="ggcatggtcataaatctccctacttttcgtgcttgatttctC TTTGACAtctcatccccttccTTTTATTATGATTGTTGTTGtttgtgaaaatcaacaa c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 2929397..2929416 /Source="Nicolas_upshift_promotors" /id="U2493" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.696303696303696" /psig="0.996003996003996" /xcortree=1594 /SigmaFactorBS="tcacaaatccatgtttttttattttcttaatcaaacaaagaa ttttccaaaatatCAAGCTACACTAAAAATATCacatatacaggaggagacagatatg a" /listShort="ald, yukJ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2929402 /Source="Nicolas_upshifts" /id="U2493" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.696303696303696" /psig="0.996003996003996" /xcortree=1594 /SigmaFactorBS="tcacaaatccatgtttttttattttcttaatcaaacaaagaa ttttccaaaatatCAAGCTACACTAAAAATATCacatatacaggaggagacagatatg a" /listShort="ald, yukJ" /GFF_Attribute="listLong" /label="upshifts" CDS 2929439..2930575 /gene="ald" /locus_tag="BSU_31930" /old_locus_tag="BSU31930" /EC_number="1.4.1.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:488097, 8226620, 22720735, 22797752, 26202482" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 488097, 8226620, 22720735, 22797752, 26202482; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="L-alanine dehydrogenase (NAD-dependent)" /protein_id="NP_391071.1" /db_xref="EnsemblGenomes-Gn:BSU31930" /db_xref="EnsemblGenomes-Tr:CAB15181" /db_xref="GOA:Q08352" /db_xref="InterPro:IPR007698" /db_xref="InterPro:IPR007886" /db_xref="InterPro:IPR008141" /db_xref="InterPro:IPR008142" /db_xref="InterPro:IPR008143" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10468" /db_xref="UniProtKB/Swiss-Prot:Q08352" /translation="MIIGVPKEIKNNENRVALTPGGVSQLISNGHRVLVETGAGLGSG FENEAYESAGAEIIADPKQVWDAEMVMKVKEPLPEEYVYFRKGLVLFTYLHLAAEPEL AQALKDKGVTAIAYETVSEGRTLPLLTPMSEVAGRMAAQIGAQFLEKPKGGKGILLAG VPGVSRGKVTIIGGGVVGTNAAKMAVGLGADVTIIDLNADRLRQLDDIFGHQIKTLIS NPVNIADAVAEADLLICAVLIPGAKAPTLVTEEMVKQMKPGSVIVDVAIDQGGIVETV DHITTHDQPTYEKHGVVHYAVANMPGAVPRTSTIALTNVTVPYALQIANKGAVKALAD NTALRAGLNTANGHVTYEAVARDLGYEYVPAEKALQDESSVAGA*" /label="ald CDS" gene 2929439..2930575 /gene="ald" /locus_tag="BSU_31930" /old_locus_tag="BSU31930" /label="ald gene" downshifts 2930575 /Source="Nicolas_upshifts" /id="D1651" /incds=0 /nref=42 /ntot=190 /MaxReadThrough="5.86626" /MaxDrop="4.4689" /score="41.2794059" /energy="-14.2" /TU="U2493" /idTUdmin="U2493" /TUdmin="-769" /isTUend="FALSE" /label="downshifts" promotor_-35 2930624..2930632 /Source="Nicolas_upshift_promotors" /id="U2494" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=521 /SigmaFactorBS="ataagcttgcagaaagatttctgcaggcttttttatttttta AAAGGAAAAaagagaccattTCACGAATTATGACTATGAagttgatcataaaggagga t" /listShort="yukJ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2930642 /Source="Nicolas_upshifts" /id="U2494" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=521 /SigmaFactorBS="ataagcttgcagaaagatttctgcaggcttttttatttttta AAAGGAAAAaagagaccattTCACGAATTATGACTATGAagttgatcataaaggagga t" /listShort="yukJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2930644..2930662 /Source="Nicolas_upshift_promotors" /id="U2494" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=521 /SigmaFactorBS="ataagcttgcagaaagatttctgcaggcttttttatttttta AAAGGAAAAaagagaccattTCACGAATTATGACTATGAagttgatcataaaggagga t" /listShort="yukJ" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2930687..2931364 /gene="yukJ" /locus_tag="BSU_31945" /old_locus_tag="BSU31945" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391073.2" /db_xref="EnsemblGenomes-Gn:BSU31945" /db_xref="EnsemblGenomes-Tr:CAB15183" /db_xref="InterPro:IPR019268" /db_xref="SubtiList:BG12380" /db_xref="UniProtKB/Swiss-Prot:C0SPB1" /translation="MAVQQYGVLKGIVLDMKRETDDDSPHFQVKMLGEENTYYRCAIN VMSSSEESEVLYLADDQFDSGSITILPNMPYGYTRINEANREVALDYVRGNLFDPREM KPLPHEITGPDNDLNDFIETYMKKAQDEKTPVYIFGSKFGPEQAADKIFGFTPTNGMH NIHMNQGNAMDTRWKKDNGSWHDGGILIQFADQWAAVFLAFLSQSWCTDENGNPVRDC DHTQTSA*" /label="yukJ CDS" gene 2930687..2931364 /gene="yukJ" /locus_tag="BSU_31945" /old_locus_tag="BSU31945" /label="yukJ gene" downshifts 2931348 /Source="Nicolas_upshifts" /id="D1652" /incds=0 /nref=37 /ntot=185 /MaxReadThrough="3.39608" /MaxDrop="5.40829" /score="9.49891506" /energy="-12" /TU="U2494" /idTUdmin="U2493" /TUdmin=4 /isTUend="TRUE" /label="downshifts" CDS complement(2931408..2931617) /gene="mbtH" /locus_tag="BSU_31959" /old_locus_tag="BSU31959" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11112781, 20845982, 21890635, 24975514, 28880538; Product type r: regulator" /codon_start=1 /transl_table=11 /product="stimulator of DhbF tyrosine adenylation activity" /protein_id="YP_003097779.1" /db_xref="EnsemblGenomes-Gn:BSU31959" /db_xref="EnsemblGenomes-Tr:CAX52685" /db_xref="InterPro:IPR005153" /db_xref="UniProtKB/Swiss-Prot:C0H3Q6" /translation="MANPFENADGTYLVLVNEEGQYSLWPGFIDVPSGWTVVHEQKGR EACLDYIQSHWSDMRPNSLKTVENV*" /label="mbtH CDS" gene complement(2931408..2931617) /gene="mbtH" /locus_tag="BSU_31959" /old_locus_tag="BSU31959" /label="mbtH gene" downshifts complement(2931420) /Source="Nicolas_upshifts" /id="D1653" /incds=0 /nref=106 /ntot=174 /MaxReadThrough="1.39981" /MaxDrop="6.23998" /score="17.380299" /energy="-12" /TU="NA" /idTUdmin="U2496" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2931633..2938769) /gene="dhbF" /locus_tag="BSU_31960" /old_locus_tag="BSU31960" /EC_number="2.7.7.-" /EC_number="5.1.1.-" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11112781, 12354229, 16672620, 18957859, 26284661, 27731335" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11112781, 12354229, 16672620, 18957859, 26284661, 27731335; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="siderophore 2,3-dihydroxybenzoate-glycine-threonine trimeric ester bacillibactin synthetase" /protein_id="NP_391076.3" /db_xref="EnsemblGenomes-Gn:BSU31960" /db_xref="EnsemblGenomes-Tr:CAB15186" /db_xref="GOA:P45745" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR001031" /db_xref="InterPro:IPR001242" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR010071" /db_xref="InterPro:IPR020802" /db_xref="InterPro:IPR020806" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="InterPro:IPR029058" /db_xref="InterPro:IPR036736" /db_xref="SubtiList:BG11243" /db_xref="UniProtKB/Swiss-Prot:P45745" /translation="MPDTKDLQYSLTGAQTGIWFAQQLDPDNPIYNTAEYIEINGPVN IALFEEALRHVIKEAESLHVRFGENMDGPWQMINPSPDVQLHVIDVSSEPDPEKTALN WMKADLAKPVDLGYAPLFNEALFIAGPDRFFWYQRIHHIAIDGFGFSLIAQRVASTYT ALIKGQTAKSRSFGSLQAILEEDTDYRGSEQYEKDRQFWLDRFADAPEVVSLADRAPR TSNSFLRHTAYLPPSDVNALKEAARYFSGSWHEVMIAVSAVYVHRMTGSEDVVLGLPM MGRIGSASLNVPAMVMNLLPLRLTVSSSMSFSELIQQISREIRSIRRHHKYRHEELRR DLKLIGENHRLFGPQINLMPFDYGLDFAGVRGTTHNLSAGPVDDLSINVYDRTDGSGL RIDVDANPEVYSESDIKLHQQRILQLLQTASAGEDMLIGQMELLLPEEKEKVISKWNE TAKSEKLVSLQDMFEKQAVLTPERIALMCDDIQVNYRKLNEEANRLARLLIEKGIGPE QFVALALPRSPEMVASMLGVLKTGAAYLPLDPEFPADRISYMLEDAKPSCIITTEEIA ASLPDDLAVPELVLDQAVTQEIIKRYSPENQDVSVSLDHPAYIIYTSGSTGRPKGVVV TQKSLSNFLLSMQEAFSLGEEDRLLAVTTVAFDISALELYLPLISGAQIVIAKKETIR EPQALAQMIENFDINIMQATPTLWHALVTSEPEKLRGLRVLVGGEALPSGLLQELQDL HCSVTNLYGPTETTIWSAAAFLEEGLKGVPPIGKPIWNTQVYVLDNGLQPVPPGVVGE LYIAGTGLARGYFHRPDLTAERFVADPYGPPGTRMYRTGDQARWRADGSLDYIGRADH QIKIRGFRIELGEIDAVLANHPHIEQAAVVVREDQPGDKRLAAYVVADAAIDTAELRR YMGASLPDYMVPSAFVEMDELPLTPNGKLDRKALPAPDFSTSVSDRAPRTPQEEILCD LFAEVLGLARVGIDDSFFELGGHSLLAARLMSRIREVMGAELGIAKLFDEPTVAGLAA HLDLAQSACPALQRAERPEKIPLSFAQRRLWFLHCLEGPSPTYNIPVAVRLSGELDQG LLKAALYDLVCRHESLRTIFPESQGTSYQHILDADRACPELHVTEIAEKELSDRLAEA VRYSFDLAAEPAFRAELFVIGPDEYVLLLLVHHIVGDGWSLTPLTRDLGTAYAARCHG RSPEWAPLAVQYADYALWQQELLGNEDDPNSLIAGQLAFWKETLKNLPDQLELPTDYS RPAEPSHDGDTIHFRIEPEFHKRLQELARANRVSLFMVLQSGLAALLTRLGAGTDIPI GSPIAGRNDDALGDLVGLFINTLVLRTDTSGDPSFRELLDRVREVNLAAYDNQDLPFE RLVEVLNPARSRATHPLFQIMLAFQNTPDAELHLPDMESSLRINSVGSAKFDLTLEIS EDRLADGTPNGMEGLLEYSTDLFKRETAQALADRLMRLLEAAESDPDEQIGNLDILAP EEHSSMVTDWQSVSEKIPHACLPEQFEKQAALRPDAIAVVYENQELSYAELNERANRL ARMMISEGVGPEQFVALALPRSLEMAVGLLAVLKAGAAYLPLDPDYPADRIAFMLKDA QPAFIMTNTKAANHIPPVENVPKIVLDDPELAEKLNTYPAGNPKNKDRTQPLSPLNTA YVIYTSGSTGVPKGVMIPHQNVTRLFAATEHWFRFSSGDIWTMFHSYAFDFSVWEIWG PLLHGGRLVIVPHHVSRSPEAFLRLLVKEGVTVLNQTPSAFYQFMQAEREQPDLGQAL SLRYVIFGGEALELSRLEDWYNRHPENRPQLINMYGITETTVHVSYIELDRSMAALRA NSLIGCGIPDLGVYVLDERLQPVPPGVAGELYVSGAGLARGYLGRPGLTSERFIADPF GPPGTRMYRTGDVARLRADGSLDYVGRADHQVKIRGFRIELGEIEAALVQHPQLEDAA VIVREDQPGDKRLAAYVIPSEETFDTAELRRYAAERLPDYMVPAAFVTMKELPLTPNG KLDRKALPAPDFAAAVTGRGPRTPQEEILCDLFMEVLHLPRVGIDDRFFDLGGHSLLA VQLMSRIREALGVELSIGNLFEAPTVAGLAERLEMGSSQSALDVLLPLRTSGDKPPLF CVHPAGGLSWCYAGLMTNIGTDYPIYGLQARGIGQREELPKTLDDMAADYIKQIRTVQ PKGPYHLLGWSLGGNVVQAMATQLQNQGEEVSLLVMLDAYPNHFLPIKEAPDDEEALI ALLALGGYDPDSLGEKPLDFEAAIEILRRDGSALASLDETVILNLKNTYVNSVGILGS YKPKTFRGNVLFFRSTIIPEWFDPIEPDSWKPYINGQIEQIDIDCRHKDLCQPEPLAQ IGKVLAVKLEELNK*" /label="dhbF CDS" gene complement(2931633..2938769) /gene="dhbF" /locus_tag="BSU_31960" /old_locus_tag="BSU31960" /label="dhbF gene" CDS complement(2938789..2939727) /gene="dhbB" /locus_tag="BSU_31970" /old_locus_tag="BSU31970" /EC_number="3.3.2.1" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8921902, 9214294, 11112781, 11790741, 12354229, 16672620, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isochorismatase (siderophore specific)" /protein_id="NP_391077.1" /db_xref="EnsemblGenomes-Gn:BSU31970" /db_xref="EnsemblGenomes-Tr:CAB15187" /db_xref="GOA:P45743" /db_xref="InterPro:IPR000868" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR016291" /db_xref="InterPro:IPR036380" /db_xref="InterPro:IPR036736" /db_xref="SubtiList:BG11241" /db_xref="UniProtKB/Swiss-Prot:P45743" /translation="MAIPAIQPYQMPTASDMPQNKVSWVPDPNRAVLLIHDMQNYFVD AFTAGASPVTELSANIRKLKNQCVQLGIPVVYTAQPGSQNPDDRALLTDFWGPGLNSG PYEEKIITELAPEDDDLVLTKWRYSAFKRTNLLEMMRKEGRDQLIITGIYAHIGCLVT ACEAFMEDIKAFFVGDAVADFSLEKHQMALEYAAGRCAFTVMTDSLLDQLQNAPADVQ KTSANTGKKNVFTCENIRKQIAELLQETPEDITDQEDLLDRGLDSVRIMTLVEQWRRE GAEVTFVELAERPTIEEWQKLLTTRSQQVLPNADYL*" /label="dhbB CDS" gene complement(2938789..2939727) /gene="dhbB" /locus_tag="BSU_31970" /old_locus_tag="BSU31970" /label="dhbB gene" CDS complement(2939755..2941374) /gene="dhbE" /locus_tag="BSU_31980" /old_locus_tag="BSU31980" /EC_number="2.7.7.58" /EC_number="6.3.2.-" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8921902, 9214294, 11112781, 11790741, 12354229, 12221282, 16672620, 16403027, 23352143, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8921902, 9214294, 11112781, 11790741, 12354229, 12221282, 16672620, 16403027, 23352143, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2,3-dihydroxybenzoate-AMP ligase" /protein_id="NP_391078.1" /db_xref="EnsemblGenomes-Gn:BSU31980" /db_xref="EnsemblGenomes-Tr:CAB15188" /db_xref="GOA:P40871" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR011963" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="PDB:1MD9" /db_xref="PDB:1MDB" /db_xref="PDB:1MDF" /db_xref="SubtiList:BG11020" /db_xref="UniProtKB/Swiss-Prot:P40871" /translation="MLKGFTPWPDELAETYRKNGCWAGETFGDLLRDRAAKYGDRIAI TCGNTHWSYRELDTRADRLAAGFQKLGIQQMDRVVVQLPNIKEFFEVIFALFRLGALP VFALPSHRSSEITYFCEFAEAAAYIIPDAYSGFDYRSLARQVQSKLPTLKNIIVAGEA EEFLPLEDLHAEPVKLPEVKSSDVAFLQLSGGSTGLSKLIPRTHDDYIYSLKRSVEVC WLDHSTVYLAALPMAHNYPLSSPGVLGVLYAGGRVVLSPSPSPDDAFPLIEREKVTIT ALVPPLAMVWMDAASSRRDDLSSLQVLQVGGAKFSAEAARRVKAVFGCTLQQVFGMAE GLVNYTRLDDPEEIIVNTQGKPMSPYDEMRVWDDHDRDVKPGETGHLLTRGPYTIRGY YKAEEHNAASFTEDGFYRTGDIVRLTRDGYIVVEGRAKDQINRGGEKVAAEEVENHLL AHPAVHDAAMVSMPDQFLGERSCVFIIPRDEAPKAAELKAFLRERGLAAYKIPDRVEF VESFPQTGVGKVSKKALREAISEKLLAGFKK*" /label="dhbE CDS" gene complement(2939755..2941374) /gene="dhbE" /locus_tag="BSU_31980" /old_locus_tag="BSU31980" /label="dhbE gene" CDS complement(2941403..2942599) /gene="dhbC" /locus_tag="BSU_31990" /old_locus_tag="BSU31990" /EC_number="5.4.4.2" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 12354229, 16672620, 19777807, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="isochorismate synthase (siderophore-specific)" /protein_id="NP_391079.2" /db_xref="EnsemblGenomes-Gn:BSU31990" /db_xref="EnsemblGenomes-Tr:CAB15189" /db_xref="GOA:P45744" /db_xref="InterPro:IPR004561" /db_xref="InterPro:IPR005801" /db_xref="InterPro:IPR015890" /db_xref="SubtiList:BG11242" /db_xref="UniProtKB/Swiss-Prot:P45744" /translation="MLDQNVITETKAEHLLHEYQPGAFFLASPHRVLLAKGICEIVPE ADGQNQMETLSGRIAEALRQAKQSGQSRPLVVGAVPFDQVKAARLVVPEEVRWSGPLQ FDHEEKEQQAGHTYHIKPVPEPEDYKNGVEQGLARIADGTLSKIVLSRSLHLTSPEPI QTDELLRHLAQHNSHGYTFAADVSSQEETSPRRTLLGASPELLVSRMGTQVVSNPLAG SRPRSNDPVEDQRRAAELLSSAKDLHEHAVVADAVAAALRPFCRTLEVPEKPSLIKTE TMWHLSSVIKGELSDPSVTALELAAALHPTPAVCGTPTDLAREAILSIEPFDRGFFTG MVGWCDDAGDGEWIVTIRCAEAEERSLRLYAGAGVVAGSKPEDELQETSAKFRTMLRA MGVDHI*" /label="dhbC CDS" gene complement(2941403..2942599) /gene="dhbC" /locus_tag="BSU_31990" /old_locus_tag="BSU31990" /label="dhbC gene" promotor_-35 2942447..2942454 /Source="Nicolas_upshift_promotors" /id="U2495" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.75024975024975" /psig="0.98001998001998" /xcortree=1925 /SigmaFactorBS="acgcctctgcaattcggccagaaagggtttcCATTTGGTttt gcccgtctgccTCCGGTACAATTTCACATATgcctttcgctaacagtacacgatgagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2942469..2942488 /Source="Nicolas_upshift_promotors" /id="U2495" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.75024975024975" /psig="0.98001998001998" /xcortree=1925 /SigmaFactorBS="acgcctctgcaattcggccagaaagggtttcCATTTGGTttt gcccgtctgccTCCGGTACAATTTCACATATgcctttcgctaacagtacacgatgagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2942476 /Source="Nicolas_upshifts" /id="U2495" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.75024975024975" /psig="0.98001998001998" /xcortree=1925 /SigmaFactorBS="acgcctctgcaattcggccagaaagggtttcCATTTGGTttt gcccgtctgccTCCGGTACAATTTCACATATgcctttcgctaacagtacacgatgagg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2942625..2943410) /gene="dhbA" /locus_tag="BSU_32000" /old_locus_tag="BSU32000" /EC_number="1.3.1.28" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12354229, 16672620, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 16672620, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase" /protein_id="NP_391080.2" /db_xref="EnsemblGenomes-Gn:BSU32000" /db_xref="EnsemblGenomes-Tr:CAB15190" /db_xref="GOA:P39071" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR003560" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11019" /db_xref="UniProtKB/Swiss-Prot:P39071" /translation="MNAKGIEGKIAFITGAAQGIGEAVARTLASQGAHIAAVDYNPEK LEKVVSSLKAEGRHAEAFPADVRDSAAIDEITARIEREMGPIDILVNVAGVLRPGLIH SLSDEEWEATFSVNSTGVFNASRSVSKYMMDRRSGSIVTVGSNAAGVPRTSMAAYASS KAAAVMFTKCLGLELAEYNIRCNIVSPGSTETDMQWSLWADENGAEQVIKGSLETFKT GIPLKKLAKPSDIADAVLFLVSGQAGHITMHNLCVDGGATLGV*" /label="dhbA CDS" gene complement(2942625..2943410) /gene="dhbA" /locus_tag="BSU_32000" /old_locus_tag="BSU32000" /label="dhbA gene" S_feature complement(2943411..2943520) /Source="Nicolas_S_feature" /locus_tag="new_3292297_3292406_c" /HighExp="HiOs, GM 15, B60, nit, GM 10, GM 25, B36, GM 60, dia0, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1228" promotor_-10 complement(2943515..2943534) /Source="Nicolas_upshift_promotors" /id="U2496" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.617382617382617" /psig=1 /xcortree=2114 /SigmaFactorBS="aaaaatatttgtcactgaaattataTTTGACTGtcacatgac atttGGATATGATTATTTTTATAAttgataatgataatcattatcaatagattgcgtt t" /listShort="S1228, dhbA, dhbC, dhbE, dhbB, dhbF, ybdZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2943520) /Source="Nicolas_upshifts" /id="U2496" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.617382617382617" /psig=1 /xcortree=2114 /SigmaFactorBS="aaaaatatttgtcactgaaattataTTTGACTGtcacatgac atttGGATATGATTATTTTTATAAttgataatgataatcattatcaatagattgcgtt t" /listShort="S1228, dhbA, dhbC, dhbE, dhbB, dhbF, ybdZ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2943522..2943603) /Source="Nicolas_S_feature" /locus_tag="new_3292408_3292489_c" /HighExp="HiOs, B60, nit, B36, GM 45, GM 10, BI, GM 15, GM 25, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1229" promotor_-35 complement(2943548..2943555) /Source="Nicolas_upshift_promotors" /id="U2496" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.617382617382617" /psig=1 /xcortree=2114 /SigmaFactorBS="aaaaatatttgtcactgaaattataTTTGACTGtcacatgac atttGGATATGATTATTTTTATAAttgataatgataatcattatcaatagattgcgtt t" /listShort="S1228, dhbA, dhbC, dhbE, dhbB, dhbF, ybdZ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2943604..2944473) /gene="besA" /locus_tag="BSU_32010" /old_locus_tag="BSU32010" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12354229, 16889643, 19673474, 26284661, 28283524; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bacillibactin trilactone hydrolase" /protein_id="NP_391081.2" /db_xref="EnsemblGenomes-Gn:BSU32010" /db_xref="EnsemblGenomes-Tr:CAB15191" /db_xref="GOA:O32102" /db_xref="InterPro:IPR000801" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG13974" /db_xref="UniProtKB/Swiss-Prot:O32102" /translation="MKEQTTDRTNGGTSNAFTIPGTEVRMMSSRNENRTYHIFISKPS TPPPPAGYPVIYLLDANSVFGTMTEAVRIQGRRPEKTGVIPAVIVGIGYETAEPFSSA RHRDFTMPTAQSKLPERPDGREWPEHGGAEGFFRFIEEDLKPEIERDYQIDKKRQTIF GHSLGGLFVLQVLLTKPDAFQTYIAGSPSIHWNKPFILKKTDHFVSLTKKNNQPINIL LAAGELEQHHKSRMNDNARELYERLAVLSEQGIRAEFCEFSGEGHISVLPVLVSRALR FALHPDGPHLSMG*" /label="besA CDS" gene complement(2943604..2944473) /gene="besA" /locus_tag="BSU_32010" /old_locus_tag="BSU32010" /label="besA gene" S_feature complement(2944474..2944554) /Source="Nicolas_S_feature" /locus_tag="new_3293360_3293440_c" /HighExp="HiOs, B60, nit, GM 15, BI, B36, LoTm, T-5.40H, Lbexp, T-4.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1230" promotor_-10 complement(2944538..2944557) /Source="Nicolas_upshift_promotors" /id="U2497" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.653346653346653" /psig=1 /xcortree=2115 /SigmaFactorBS="ttatttgatcaaggtgccttttttattcgggaaaaaGTTGAC TTtctttggaagaaaACCTATTATTTGAGGTGTCTagttgatagtgaaaatcattatc a" /listShort="S1230, besA, S1229, S1228, dhbA, dhbC, dhbE, dhbB, dhbF, ybdZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2944554) /Source="Nicolas_upshifts" /id="U2497" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.653346653346653" /psig=1 /xcortree=2115 /SigmaFactorBS="ttatttgatcaaggtgccttttttattcgggaaaaaGTTGAC TTtctttggaagaaaACCTATTATTTGAGGTGTCTagttgatagtgaaaatcattatc a" /listShort="S1230, besA, S1229, S1228, dhbA, dhbC, dhbE, dhbB, dhbF, ybdZ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2944571..2944578) /Source="Nicolas_upshift_promotors" /id="U2497" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.653346653346653" /psig=1 /xcortree=2115 /SigmaFactorBS="ttatttgatcaaggtgccttttttattcgggaaaaaGTTGAC TTtctttggaagaaaACCTATTATTTGAGGTGTCTagttgatagtgaaaatcattatc a" /listShort="S1230, besA, S1229, S1228, dhbA, dhbC, dhbE, dhbB, dhbF, ybdZ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2944687..2945283) /gene="yuiH" /locus_tag="BSU_32020" /old_locus_tag="BSU32020" /EC_number="1.7.3.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11598126, 16341843, 21190336; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative molybdopterin containing enzyme subunit" /protein_id="NP_391082.1" /db_xref="EnsemblGenomes-Gn:BSU32020" /db_xref="EnsemblGenomes-Tr:CAB15192" /db_xref="GOA:O32103" /db_xref="InterPro:IPR000572" /db_xref="InterPro:IPR036374" /db_xref="SubtiList:BG13973" /db_xref="UniProtKB/Swiss-Prot:O32103" /translation="MYFGKTRQSDQSGRVPPNQNVTTSFPVLHTGDVPYYEDMTKWNL QVYGLVDHPMLLSFEDVKAFPRYESKNDIHCVTGWSRLDNVWQGVRACDIAEKAGVKE EAGYVILHAEEGWTTNLPLDDFLAETSLLAYAHNGEPLTPEHGFPLRGVFPHLYFWKS AKWLRGIQFTKENHPGFWERNGYHMRGDPWQNQRFTWD*" /label="yuiH CDS" gene complement(2944687..2945283) /gene="yuiH" /locus_tag="BSU_32020" /old_locus_tag="BSU32020" /label="yuiH gene" S_feature complement(2945284..2945368) /Source="Nicolas_S_feature" /locus_tag="new_3294170_3294254_c" /HighExp="H2O2, Paraq, Cold, dia15, G135, B36, G180, B60, LoTm, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.204" /TUlongSig="NA" /TUlongPSig="NA" /label="S1231" promotor_-35 2945319..2945326 /Source="Nicolas_upshift_promotors" /id="U2498" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2920 /SigmaFactorBS="aaatacatatgggcctcctttttgttaacctaatttaaaatc aTGTTGACAatctttttgttcttTATTACTCTATGATTGTGTAtgtcaacctaagggg g" /listShort="bioYB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2945336 /Source="Nicolas_upshifts" /id="U2498" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2920 /SigmaFactorBS="aaatacatatgggcctcctttttgttaacctaatttaaaatc aTGTTGACAatctttttgttcttTATTACTCTATGATTGTGTAtgtcaacctaagggg g" /listShort="bioYB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2945341..2945360 /Source="Nicolas_upshift_promotors" /id="U2498" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.997002997002997" /psig=1 /xcortree=2920 /SigmaFactorBS="aaatacatatgggcctcctttttgttaacctaatttaaaatc aTGTTGACAatctttttgttcttTATTACTCTATGATTGTGTAtgtcaacctaagggg g" /listShort="bioYB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2945362..2945376) /Source="Nicolas_upshift_promotors" /id="U2499" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.724275724275724" /psig="0.203796203796204" /xcortree=588 /SigmaFactorBS="gccaatcagcgccatatctcccgcacgaagtttacgttgtTT CATcgttgttCCCCCTTAGGTTGACatacacaatcatagagtaataaagaacaaaaag a" /listShort="S1231, yuiH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2945368) /Source="Nicolas_upshifts" /id="U2499" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.724275724275724" /psig="0.203796203796204" /xcortree=588 /SigmaFactorBS="gccaatcagcgccatatctcccgcacgaagtttacgttgtTT CATcgttgttCCCCCTTAGGTTGACatacacaatcatagagtaataaagaacaaaaag a" /listShort="S1231, yuiH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2945384..2945388) /Source="Nicolas_upshift_promotors" /id="U2499" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.724275724275724" /psig="0.203796203796204" /xcortree=588 /SigmaFactorBS="gccaatcagcgccatatctcccgcacgaagtttacgttgtTT CATcgttgttCCCCCTTAGGTTGACatacacaatcatagagtaataaagaacaaaaag a" /listShort="S1231, yuiH" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2945384..2945986 /gene="bioYB" /locus_tag="BSU_32030" /old_locus_tag="BSU32030" /function="16.1: Circulate" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11717296, 15849754, 16850406, 24816803; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative biotin transporter" /protein_id="NP_391083.1" /db_xref="EnsemblGenomes-Gn:BSU32030" /db_xref="EnsemblGenomes-Tr:CAB15193" /db_xref="GOA:O32104" /db_xref="InterPro:IPR003784" /db_xref="SubtiList:BG13972" /db_xref="UniProtKB/Swiss-Prot:O32104" /translation="MKQRKLRAGDMALIGMFAALMAVGANITSVAPFLQVAGIPLSMQ PFFCLLAALLLGSKRAAIAMIVYALVGLAGAPVFAQFSAGFAPFAGKSGGFIISYIPA AFAAGWFLERNIQPSKIRFLIASLIGTAIMYLIGTTYMYLALKLWIHTPVSYGTAWGF MIWFMVKDTALAVILSFIAPAIYRSIHKATGFNRNHISST*" /label="bioYB CDS" gene 2945384..2945986 /gene="bioYB" /locus_tag="BSU_32030" /old_locus_tag="BSU32030" /label="bioYB gene" downshifts 2945972 /Source="Nicolas_upshifts" /id="D1654" /incds=0 /nref=145 /ntot=206 /MaxReadThrough="3.24182" /MaxDrop="6.72885" /score="12.6395055" /energy="-6.3" /TU="U2498" /idTUdmin="U2498" /TUdmin="-24" /isTUend="FALSE" /label="downshifts" CDS complement(2946056..2947384) /gene="hisP" /locus_tag="BSU_32040" /old_locus_tag="BSU32040" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15135544, 15849754, 16850406, 23504016; Product type t : transporter" /codon_start=1 /transl_table=11 /product="histidine / basic amino acid transporter" /protein_id="NP_391084.1" /db_xref="EnsemblGenomes-Gn:BSU32040" /db_xref="EnsemblGenomes-Tr:CAB15194" /db_xref="GOA:O32105" /db_xref="InterPro:IPR018461" /db_xref="InterPro:IPR032813" /db_xref="SubtiList:BG13971" /db_xref="UniProtKB/Swiss-Prot:O32105" /translation="MNAVVIAVLLMLVLSLLRVNIVIALIIGALAGGLTGGLGLGETV KAFTDGLGGNATVAVSYAMLGAFAAALTKTGLPDAMVEASVKLIGNKEDSRKKALSKV LIVLIILIVSCFSQNVVPVHIAFIPVLIPPLLKIFNELEMDRRLIACVITFGLTAPYI LLPVGFGQIFQGMLKDNMADAGLNVPLADIPYALIIPVAGMVVGLILSVIVYRKPKQY ETKDISGAEASPYTRKSIGIAVLAIVVSLGVQLYLSQTLGVEGMIMGALAGLIVLFVS GVMKRDEADSLITDGMVLMAFIGFVMLVAAGFSNVLTKTGDVESLVKTSAGFIGHSQS LGALLMLIVGLLITMGIGSSFATIPVITTIFVPLCMQLGFSPMATIAIIGAAAALGDA GSPASDSTLGPTSGLSADGQHHHIWDTCVPTFIFYNIPLVIFGWIAALVL*" /label="hisP CDS" gene complement(2946056..2947384) /gene="hisP" /locus_tag="BSU_32040" /old_locus_tag="BSU32040" /label="hisP gene" downshifts complement(2946072) /Source="Nicolas_upshifts" /id="D1655" /incds=0 /nref=14 /ntot=114 /MaxReadThrough="4.26298" /MaxDrop="4.37949" /score="18.6861113" /energy="-15.4" /TU="U2500" /idTUdmin="U2500" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2947438..2947457) /Source="Nicolas_upshift_promotors" /id="U2500" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=2776 /SigmaFactorBS="ggattttttcttccgaaatcttTAGTTGACtaaagtggatcg gtTATGATACGATACGTTCGTActttatttatctactacattagcaaactaaaggatt t" /listShort="yuiF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2947441) /Source="Nicolas_upshifts" /id="U2500" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=2776 /SigmaFactorBS="ggattttttcttccgaaatcttTAGTTGACtaaagtggatcg gtTATGATACGATACGTTCGTActttatttatctactacattagcaaactaaaggatt t" /listShort="yuiF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2947472..2947479) /Source="Nicolas_upshift_promotors" /id="U2500" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=2776 /SigmaFactorBS="ggattttttcttccgaaatcttTAGTTGACtaaagtggatcg gtTATGATACGATACGTTCGTActttatttatctactacattagcaaactaaaggatt t" /listShort="yuiF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2947531..2949033) /gene="pepA" /locus_tag="BSU_32050" /old_locus_tag="BSU32050" /EC_number="3.4.11.1" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8057849, 9864319, 10449417, 26936797; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytosol aminopeptidase" /protein_id="NP_391085.1" /db_xref="EnsemblGenomes-Gn:BSU32050" /db_xref="EnsemblGenomes-Tr:CAB15195" /db_xref="GOA:O32106" /db_xref="InterPro:IPR000819" /db_xref="InterPro:IPR008283" /db_xref="InterPro:IPR011356" /db_xref="InterPro:IPR023042" /db_xref="SubtiList:BG13970" /db_xref="UniProtKB/Swiss-Prot:O32106" /translation="MFYAVQQSEHTETLVVGLFQKSQLTGKALEIDEMLEGHLTQLLK EGDVSAKPNQVSKVFPPSSAGMKRIYFVGLGREANYSFEQAKERFAHVFQAIHKDRKQ ETAVLLDTFISEDVPPADAAHALAESCLLASYEVQDYKHKSNEPDKQIEAVYVVTDED TQEVQAGLRVGQAYGQGTNSARTLVNMPGNMLTATDLASYAEELAAKYDFECEILEKS EMEELGMGGILAVNQGSTEPPKMIVLKYQGKKEWEDVVGLVGKGITFDTGGYSIKTKS GIVGMKSDMGGAAAVLGAMETIGELRPEQNVLCVIPSTDNMISGGAMKPDDVIVSLSG KTIEILNTDAEGRLVLADGITYAKQHGASVLVDVATLTGGVVVALGTETTGAMTNDQS FYQQVADAAQECGEAIWQLPITEKDKKRVKSSQMADLSNSPGREGHAIMAGTFLGEFA ESTPWVHLDIAGTATANKATCFGPAGATGVMARTLATLAERFTLEEDKNE*" /label="pepA CDS" gene complement(2947531..2949033) /gene="pepA" /locus_tag="BSU_32050" /old_locus_tag="BSU32050" /label="pepA gene" downshifts complement(2947546) /Source="Nicolas_upshifts" /id="D1656" /incds=0 /nref=149 /ntot=220 /MaxReadThrough="4.44151" /MaxDrop="5.59726" /score="31.6277104" /energy="-16" /TU="NA" /idTUdmin="U2503" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature 2948598..2948612 /Source="Nicolas_upshift_promotors" /id="U2501" /multdbtbs="-" /comp="M19" /sig="Sig-" /pcomp="0.345654345654346" /psig="0.420579420579421" /xcortree=308 /SigmaFactorBS="atcttcatctgttacaacatacacggcttcaatttgtttgtc agGCTCATTTGATTTATgcttataatcctgcacctcataggaagcaagcaggcagctc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 2948614 /Source="Nicolas_upshifts" /id="U2501" /multdbtbs="-" /comp="M19" /sig="Sig-" /pcomp="0.345654345654346" /psig="0.420579420579421" /xcortree=308 /SigmaFactorBS="atcttcatctgttacaacatacacggcttcaatttgtttgtc agGCTCATTTGATTTATgcttataatcctgcacctcataggaagcaagcaggcagctc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2949034..2949108) /Source="Nicolas_S_feature" /locus_tag="new_3297920_3297994_c" /HighExp="M40t90, Lbtran, LBGtran, Lbstat, C90, M0t90, T1.0H, LoTm, M40t45, BI" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1232" promotor_-35 2949056..2949063 /Source="Nicolas_upshift_promotors" /id="U2502" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.927072927072927" /psig="0.997002997002997" /xcortree=617 /SigmaFactorBS="ttgaaccgcataaaacatgaggcttacactcctaacgtaaTG GGTATTtgtaatgaacAATGGTATAATAGGAAAAACattctttccactatacttattt t" /listShort="S1233, yuiD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2949074..2949093 /Source="Nicolas_upshift_promotors" /id="U2502" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.927072927072927" /psig="0.997002997002997" /xcortree=617 /SigmaFactorBS="ttgaaccgcataaaacatgaggcttacactcctaacgtaaTG GGTATTtgtaatgaacAATGGTATAATAGGAAAAACattctttccactatacttattt t" /listShort="S1233, yuiD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 2949076..2949190 /Source="Nicolas_S_feature" /locus_tag="new_3297962_3298076" /HighExp="Etha, Cold, Gly, Sw, LoTm, BC, B60, C90, dia5, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1233" upshifts 2949076 /Source="Nicolas_upshifts" /id="U2502" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.927072927072927" /psig="0.997002997002997" /xcortree=617 /SigmaFactorBS="ttgaaccgcataaaacatgaggcttacactcctaacgtaaTG GGTATTtgtaatgaacAATGGTATAATAGGAAAAACattctttccactatacttattt t" /listShort="S1233, yuiD" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(2949103..2949122) /Source="Nicolas_upshift_promotors" /id="U2503" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.601398601398601" /psig="0.999000999001" /xcortree=3139 /SigmaFactorBS="tttgaaaaatccttcgtgtttcaaaagaaaaaagcaagtctt agactgttgTTTGTTAAAATAAGTATAGTggaaagaatgtttttcctattataccatt g" /listShort="S1232, pepA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2949113) /Source="Nicolas_upshifts" /id="U2503" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.601398601398601" /psig="0.999000999001" /xcortree=3139 /SigmaFactorBS="tttgaaaaatccttcgtgtttcaaaagaaaaaagcaagtctt agactgttgTTTGTTAAAATAAGTATAGTggaaagaatgtttttcctattataccatt g" /listShort="S1232, pepA" /GFF_Attribute="listLong" /label="upshifts" CDS 2949191..2949667 /gene="yuiD" /locus_tag="BSU_32060" /old_locus_tag="BSU32060" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391086.1" /db_xref="EnsemblGenomes-Gn:BSU32060" /db_xref="EnsemblGenomes-Tr:CAB15196" /db_xref="GOA:O32107" /db_xref="InterPro:IPR003832" /db_xref="SubtiList:BG13969" /db_xref="UniProtKB/Swiss-Prot:O32107" /translation="MELLTNFPLLSSLAAIIFAQVIKVPIQFIVSRKLDWSLVTSTGG MPSSHSAAVTALSTGVALEHGLDSSLFAVSAIFAVITMFDATGVRRHAGEQATVINKL VIDFNRFVNEAKDFPKAAEKEKQKKLKELLGHQPIEVFFGGLTGILLTLVLAYFFM*" /label="yuiD CDS" gene 2949191..2949667 /gene="yuiD" /locus_tag="BSU_32060" /old_locus_tag="BSU32060" /label="yuiD gene" downshifts 2949616 /Source="Nicolas_upshifts" /id="D1657" /incds=0 /nref=18 /ntot=174 /MaxReadThrough="3.22946" /MaxDrop="3.90704" /score="10.9647804" /energy="-11.6" /TU="U2502" /idTUdmin="U2502" /TUdmin="-208" /isTUend="FALSE" /label="downshifts" CDS complement(2949698..2950354) /gene="spsC" /locus_tag="BSU_32070" /old_locus_tag="BSU32070" /experiment="publication(s) with functional evidences, PMID:26163297" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 26163297; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="stationary phase survival protein" /protein_id="NP_391087.1" /db_xref="EnsemblGenomes-Gn:BSU32070" /db_xref="EnsemblGenomes-Tr:CAB15197" /db_xref="GOA:O32108" /db_xref="InterPro:IPR010611" /db_xref="InterPro:IPR036908" /db_xref="PDB:4WJT" /db_xref="PDB:4WLI" /db_xref="PDB:4WLK" /db_xref="SubtiList:BG13968" /db_xref="UniProtKB/Swiss-Prot:O32108" /translation="MMLNMIRRLLMTCLFLLAFGTTFLSVSGIEAKDLSKWVQEHQEK HLKHAGLRLKALQQKQTQTTSAAEDKTKPLEEAFDWDEYPVQRVTATGYTAGAESTGK NPGDPLYGLTYSGVKVKRDLYSTVAADPSVFPIGTILFIPNYGLGVVADTGSAIKGNR LDLYFETVKDVYNEWGKKTLDVYVIKKGTGKITEDELEKLNETKSLQVFRNQYKTVKE *" /label="spsC CDS" gene complement(2949698..2950354) /gene="spsC" /locus_tag="BSU_32070" /old_locus_tag="BSU32070" /label="spsC gene" downshifts complement(2949726) /Source="Nicolas_upshifts" /id="D1658" /incds=0 /nref=178 /ntot=253 /MaxReadThrough="0.714039999999999" /MaxDrop="6.31907" /score="33.0538307" /energy="-12.6" /TU="NA" /idTUdmin="U2505" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-35 2950002..2950011 /Source="Nicolas_upshift_promotors" /id="U2504" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1331 /SigmaFactorBS="tggaatataaatcccgtttcACTTTCACACctgaatatgtaa gCCCGTATAATGGATCACCGGgatttttgcccgtcgactcagctcctgctgtgtagcc t" /listShort="S1234, S1235, S1236, S1237" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2950025..2950044 /Source="Nicolas_upshift_promotors" /id="U2504" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1331 /SigmaFactorBS="tggaatataaatcccgtttcACTTTCACACctgaatatgtaa gCCCGTATAATGGATCACCGGgatttttgcccgtcgactcagctcctgctgtgtagcc t" /listShort="S1234, S1235, S1236, S1237" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2950042 /Source="Nicolas_upshifts" /id="U2504" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1331 /SigmaFactorBS="tggaatataaatcccgtttcACTTTCACACctgaatatgtaa gCCCGTATAATGGATCACCGGgatttttgcccgtcgactcagctcctgctgtgtagcc t" /listShort="S1234, S1235, S1236, S1237" /GFF_Attribute="listLong" /label="upshifts" S_feature 2950044..2950490 /Source="Nicolas_S_feature" /locus_tag="new_3298930_3299376" /HighExp="S6, S8, S7, BT, B36, G/S, S5, Pyr, Cold, B60" /AntisenseName="yuiC" /AntisenseCor="0.52395204592174105" /AntisenseRegPval="-19.600000000000001" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1234" upshifts complement(2950368) /Source="Nicolas_upshifts" /id="U2505" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp="0.543456543456543" /psig="0.543456543456543" /xcortree=1022 /SigmaFactorBS="ttatgcgttcagctcattcaccatttTGAATAAtgctctctc cacttGGGAACAATGATtcggaggagaggtgaatgatgttgaatatgatcagacgttt g" /listShort="yuiC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2950370..2950381) /Source="Nicolas_upshift_promotors" /id="U2505" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp="0.543456543456543" /psig="0.543456543456543" /xcortree=1022 /SigmaFactorBS="ttatgcgttcagctcattcaccatttTGAATAAtgctctctc cacttGGGAACAATGATtcggaggagaggtgaatgatgttgaatatgatcagacgttt g" /listShort="yuiC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2950396..2950402) /Source="Nicolas_upshift_promotors" /id="U2505" /multdbtbs="SigF" /comp="M8" /sig="SigGF" /pcomp="0.543456543456543" /psig="0.543456543456543" /xcortree=1022 /SigmaFactorBS="ttatgcgttcagctcattcaccatttTGAATAAtgctctctc cacttGGGAACAATGATtcggaggagaggtgaatgatgttgaatatgatcagacgttt g" /listShort="yuiC" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2950447 /Source="Nicolas_upshifts" /id="D1659" /incds=0 /nref=3 /ntot=11 /MaxReadThrough="7.61734" /MaxDrop="4.9382" /score="4.8726481" /energy="-7.9" /TU="U2504" /idTUdmin="U2506" /TUdmin="-323" /isTUend="FALSE" /label="downshifts" CDS complement(2950458..2950778) /gene="yuiB" /locus_tag="BSU_32080" /old_locus_tag="BSU32080" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391088.1" /db_xref="EnsemblGenomes-Gn:BSU32080" /db_xref="EnsemblGenomes-Tr:CAB15198" /db_xref="GOA:O32109" /db_xref="InterPro:IPR025917" /db_xref="SubtiList:BG13967" /db_xref="UniProtKB/Swiss-Prot:O32109" /translation="MISLPVVIISIVLFFVLFFGIGFLLNMLLRMSWIMAVIYPIVCL FIISKEKLISYVQSPGESFASLFHRVLSLAAADVLILVSGLAGAIVSGIAINMLRKRG YQMF*" /label="yuiB CDS" gene complement(2950458..2950778) /gene="yuiB" /locus_tag="BSU_32080" /old_locus_tag="BSU32080" /label="yuiB gene" downshifts complement(2950472) /Source="Nicolas_upshifts" /id="D1660" /incds=0 /nref=151 /ntot=218 /MaxReadThrough="4.24535" /MaxDrop="5.6597" /score="13.4559443" /energy="-7.6" /TU="U2507,U2508" /idTUdmin="U2510" /TUdmin=660 /isTUend="FALSE" /label="downshifts" S_feature 2950492..2950702 /Source="Nicolas_S_feature" /locus_tag="new_3299378_3299588" /HighExp="S8, S6, S7, BT, Cold, Gly, H2O2, G/S, C30, G180" /AntisenseName="yuiB" /AntisenseCor="-0.11290507783715401" /AntisenseRegPval="-1.2" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1235" promotor_no_box 2950644..2950744 /Source="Nicolas_upshift_promotors" /id="U2506" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.641358641358641" /psig="0.02997002997003" /xcortree=280 /SigmaFactorBS="gaaaaggcatacaattggataaatcacagccataatccaaga cattctcagcagcatgtttaataagaaaccgattccaaaaaacaagacaaaaaacaaa a" /listShort="S1236" /GFF_Attribute="listLong" /label="promotor_no_box" S_feature 2950704..2950813 /Source="Nicolas_S_feature" /locus_tag="new_3299590_3299699" /HighExp="S8, S6, BT, S7, Sw, Gly, G180, BC, Diami, H2O2" /AntisenseName="yuiB" /AntisenseCor="-7.7565560595235006E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigK" /TUshortPSig="0.03, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1236" upshifts 2950704 /Source="Nicolas_upshifts" /id="U2506" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.641358641358641" /psig="0.02997002997003" /xcortree=280 /SigmaFactorBS="gaaaaggcatacaattggataaatcacagccataatccaaga cattctcagcagcatgtttaataagaaaccgattccaaaaaacaagacaaaaaacaaa a" /listShort="S1236" /GFF_Attribute="listLong" /label="upshifts" downshifts 2950770 /Source="Nicolas_upshifts" /id="D1661" /incds=0 /nref=10 /ntot=28 /MaxReadThrough="3.79664" /MaxDrop="6.06021" /score="4.8726481" /energy="-7.9" /TU="U2504" /idTUdmin="U2506" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2950797..2950816) /Source="Nicolas_upshift_promotors" /id="U2507" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.797202797202797" /psig="0.995004995004995" /xcortree=435 /SigmaFactorBS="aaaagacagtcattctttttccagCCGTTGACtttatttcag ccccCGCGTTACACTAAAAACAACgcaggggggtggaataggttgattagtctgccag t" /listShort="yuiB, yuiC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2950802) /Source="Nicolas_upshifts" /id="U2507" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.797202797202797" /psig="0.995004995004995" /xcortree=435 /SigmaFactorBS="aaaagacagtcattctttttccagCCGTTGACtttatttcag ccccCGCGTTACACTAAAAACAACgcaggggggtggaataggttgattagtctgccag t" /listShort="yuiB, yuiC" /GFF_Attribute="listLong" /label="upshifts" S_feature 2950815..2951366 /Source="Nicolas_S_feature" /locus_tag="new_3299701_3300252" /HighExp="S6, S8, S7, Cold, H2O2, BC, Sw, Pyr, BT, C30" /AntisenseName="yuiA" /AntisenseCor="5.87811391089679E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1237" promotor_-35 complement(2950831..2950838) /Source="Nicolas_upshift_promotors" /id="U2507" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.797202797202797" /psig="0.995004995004995" /xcortree=435 /SigmaFactorBS="aaaagacagtcattctttttccagCCGTTGACtttatttcag ccccCGCGTTACACTAAAAACAACgcaggggggtggaataggttgattagtctgccag t" /listShort="yuiB, yuiC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2950832..2950975) /gene="yuiA" /locus_tag="BSU_32090" /old_locus_tag="BSU32090" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391089.1" /db_xref="EnsemblGenomes-Gn:BSU32090" /db_xref="EnsemblGenomes-Tr:CAB15199" /db_xref="InterPro:IPR035272" /db_xref="InterPro:IPR036410" /db_xref="SubtiList:BG12389" /db_xref="UniProtKB/Swiss-Prot:O32110" /translation="MKTATTTASHACPFCSGKGYFQLILGGSETCPSCQGTGKDSHSF SSR*" /label="yuiA CDS" gene complement(2950832..2950975) /gene="yuiA" /locus_tag="BSU_32090" /old_locus_tag="BSU32090" /label="yuiA gene" promotor_-10 complement(2950999..2951018) /Source="Nicolas_upshift_promotors" /id="U2508" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.657342657342657" /psig="0.999000999001" /xcortree=2880 /SigmaFactorBS="gtatgtttccgcttacatcaaaagatttgtcacatgatctga cTTTAtTgttgacagcttgaTATGGTATATTATCAGAAAAttaagaaaaagggtgatg a" /listShort="yuiA, yuiB, yuiC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2951020) /Source="Nicolas_upshifts" /id="U2508" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.657342657342657" /psig="0.999000999001" /xcortree=2880 /SigmaFactorBS="gtatgtttccgcttacatcaaaagatttgtcacatgatctga cTTTAtTgttgacagcttgaTATGGTATATTATCAGAAAAttaagaaaaagggtgatg a" /listShort="yuiA, yuiB, yuiC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2951034..2951037) /Source="Nicolas_upshift_promotors" /id="U2508" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.657342657342657" /psig="0.999000999001" /xcortree=2880 /SigmaFactorBS="gtatgtttccgcttacatcaaaagatttgtcacatgatctga cTTTAtTgttgacagcttgaTATGGTATATTATCAGAAAAttaagaaaaagggtgatg a" /listShort="yuiA, yuiB, yuiC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2951148..2952368) /gene="yumB" /locus_tag="BSU_32100" /old_locus_tag="BSU32100" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15937154, 17015645, 26098117; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NAD-disulfide oxidoreductase" /protein_id="NP_391090.1" /db_xref="EnsemblGenomes-Gn:BSU32100" /db_xref="EnsemblGenomes-Tr:CAB15200" /db_xref="GOA:O05267" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG12390" /db_xref="UniProtKB/Swiss-Prot:O05267" /translation="MALNKPKIVILGAGYGGLMTVTRLTKYVGPNDADITLVNKHNYH YETTWMHEASAGTLHHDRCRYQIKDVINQSRVNFVQDTVKAIKIDEKKVVLANGELQY DYLVIGLGAVPETFGIKGLKEYAFPIANINTSRLLREHIELQFATYNTEAEKRPDRLT IVVGGAGFTGIEFLGELAARVPELCKEYDVDRSLVRIICVEAAPTVLPGFDPELVDYA VHYLEENGVEFKIGTAVQECTPEGVRVGKKDEEPEQIKSQTVVWAAGVRGHPIVEEAG FENMRGRVKVNPDLRAPGHDNVFILGDSSLFMNEDTERPYPPTAQIAMQQGITVAKNL GRLIKGGELEEFKPDIKGTVASLGEHNAVGVVYGRKLKGTPASFMKKVIDNRSLFMIG GLGLTLKKGKFKFF*" /label="yumB CDS" gene complement(2951148..2952368) /gene="yumB" /locus_tag="BSU_32100" /old_locus_tag="BSU32100" /label="yumB gene" downshifts complement(2951176) /Source="Nicolas_upshifts" /id="D1662" /incds=0 /nref=15 /ntot=123 /MaxReadThrough="3.19525" /MaxDrop="3.6794" /score="23.523765" /energy="-8.9" /TU="U2510" /idTUdmin="U2509" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2952369..2952496) /Source="Nicolas_S_feature" /locus_tag="new_3301255_3301382_c" /HighExp="Salt, S4, Etha, S5, S3, S7, S6, LoTm, B36, S8" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigA" /TUshortPSig="0.752, 0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1238" upshifts complement(2952496) /Source="Nicolas_upshifts" /id="U2509" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.752247752247752" /psig="0.752247752247752" /xcortree=1120 /SigmaFactorBS="aaatgaaatgatctttttcTGAATGtttcttgggccagccGG ATAAACATGATAATAGTgctacgggtaaggacttcacaaaaaacttttcaatatattt c" /listShort="S1238, yumB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2952498..2952562) /Source="Nicolas_S_feature" /locus_tag="new_3301384_3301448_c" /HighExp="Salt, Etha, Heat, BMM, BC, H2O2, Paraq, C30, Sw, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1239" promotor_-10 complement(2952498..2952516) /Source="Nicolas_upshift_promotors" /id="U2509" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.752247752247752" /psig="0.752247752247752" /xcortree=1120 /SigmaFactorBS="aaatgaaatgatctttttcTGAATGtttcttgggccagccGG ATAAACATGATAATAGTgctacgggtaaggacttcacaaaaaacttttcaatatattt c" /listShort="S1238, yumB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2952532..2952537) /Source="Nicolas_upshift_promotors" /id="U2509" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.752247752247752" /psig="0.752247752247752" /xcortree=1120 /SigmaFactorBS="aaatgaaatgatctttttcTGAATGtttcttgggccagccGG ATAAACATGATAATAGTgctacgggtaaggacttcacaaaaaacttttcaatatattt c" /listShort="S1238, yumB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2952553..2952572) /Source="Nicolas_upshift_promotors" /id="U2510" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.460539460539461" /psig="0.993006993006993" /xcortree=671 /SigmaFactorBS="tcgtaaggatctaacgtgcccatccgtTCTTGAAAatatttc cgcaggcCGCTACGATAATAACCAAATgaaatgatctttttctgaatgtttcttgggc c" /listShort="S1239, S1238, yumB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2952561) /Source="Nicolas_upshifts" /id="U2510" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.460539460539461" /psig="0.993006993006993" /xcortree=671 /SigmaFactorBS="tcgtaaggatctaacgtgcccatccgtTCTTGAAAatatttc cgcaggcCGCTACGATAATAACCAAATgaaatgatctttttctgaatgtttcttgggc c" /listShort="S1239, S1238, yumB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2952587..2952594) /Source="Nicolas_upshift_promotors" /id="U2510" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.460539460539461" /psig="0.993006993006993" /xcortree=671 /SigmaFactorBS="tcgtaaggatctaacgtgcccatccgtTCTTGAAAatatttc cgcaggcCGCTACGATAATAACCAAATgaaatgatctttttctgaatgtttcttgggc c" /listShort="S1239, S1238, yumB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2952636..2952643 /Source="Nicolas_upshift_promotors" /id="U2511" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.847152847152847" /psig=1 /xcortree=2382 /SigmaFactorBS="acggatgggcacgttagatccttacgattttttctgctgacT CGTCAATttgaacggcaaTATGGTATAATTAATAACAAttttcatttaggaggcaatt t" /listShort="yumC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2952655..2952674 /Source="Nicolas_upshift_promotors" /id="U2511" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.847152847152847" /psig=1 /xcortree=2382 /SigmaFactorBS="acggatgggcacgttagatccttacgattttttctgctgacT CGTCAATttgaacggcaaTATGGTATAATTAATAACAAttttcatttaggaggcaatt t" /listShort="yumC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2952655 /Source="Nicolas_upshifts" /id="U2511" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.847152847152847" /psig=1 /xcortree=2382 /SigmaFactorBS="acggatgggcacgttagatccttacgattttttctgctgacT CGTCAATttgaacggcaaTATGGTATAATTAATAACAAttttcatttaggaggcaatt t" /listShort="yumC" /GFF_Attribute="listLong" /label="upshifts" CDS 2952700..2953698 /gene="trxBB" /locus_tag="BSU_32110" /old_locus_tag="BSU32110" /EC_number="1.18.1.2" /function="16.2: Construct biomass (Anabolism)" /function="16.7: Manage energy" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:15252706, 22938038, 26507228, 26965753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15252706, 22938038, 26507228, 26965753; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ferredoxin-NADP+ reductase (flavodoxin)" /protein_id="NP_391091.2" /db_xref="EnsemblGenomes-Gn:BSU32110" /db_xref="EnsemblGenomes-Tr:CAB15201" /db_xref="GOA:O05268" /db_xref="InterPro:IPR000103" /db_xref="InterPro:IPR022890" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="PDB:3LZW" /db_xref="PDB:3LZX" /db_xref="SubtiList:BG12391" /db_xref="UniProtKB/Swiss-Prot:O05268" /translation="MREDTKVYDITIIGGGPVGLFTAFYGGMRQASVKIIESLPQLGG QLSALYPEKYIYDVAGFPKIRAQELINNLKEQMAKFDQTICLEQAVESVEKQADGVFK LVTNEETHYSKTVIITAGNGAFKPRKLELENAEQYEGKNLHYFVDDLQKFAGRRVAIL GGGDSAVDWALMLEPIAKEVSIIHRRDKFRAHEHSVENLHASKVNVLTPFVPAELIGE DKIEQLVLEEVKGDRKEILEIDDLIVNYGFVSSLGPIKNWGLDIEKNSIVVKSTMETN IEGFFAAGDICTYEGKVNLIASGFGEAPTAVNNAKAYMDPKARVQPLHSTSLFENK*" /label="trxBB CDS" gene 2952700..2953698 /gene="trxBB" /locus_tag="BSU_32110" /old_locus_tag="BSU32110" /label="trxBB gene" promotor_-10 complement(2952723..2952741) /Source="Nicolas_upshift_promotors" /id="U2512" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1201 /SigmaFactorBS="gacgcttgcctgtctcatcccgccgtaaaaagcggTGAATAa gccgaccggtcccccGCCTATAATTGTAATATCAtaaacctttgtatcctctcgcata c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2952738) /Source="Nicolas_upshifts" /id="U2512" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1201 /SigmaFactorBS="gacgcttgcctgtctcatcccgccgtaaaaagcggTGAATAa gccgaccggtcccccGCCTATAATTGTAATATCAtaaacctttgtatcctctcgcata c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2952758..2952763) /Source="Nicolas_upshift_promotors" /id="U2512" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1201 /SigmaFactorBS="gacgcttgcctgtctcatcccgccgtaaaaagcggTGAATAa gccgaccggtcccccGCCTATAATTGTAATATCAtaaacctttgtatcctctcgcata c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2953674 /Source="Nicolas_upshifts" /id="D1663" /incds=0 /nref=162 /ntot=262 /MaxReadThrough="0.70088" /MaxDrop="7.47867" /score="21.6819221" /energy="-12.8" /TU="U2511" /idTUdmin="U2511" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(2953737..2953877) /gene="yuzG" /locus_tag="BSU_32120" /old_locus_tag="BSU32120" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein or unknown function" /protein_id="NP_391092.1" /db_xref="EnsemblGenomes-Gn:BSU32120" /db_xref="EnsemblGenomes-Tr:CAB15202" /db_xref="GOA:O32111" /db_xref="SubtiList:BG14056" /db_xref="UniProtKB/Swiss-Prot:O32111" /translation="MAQNEEKTPKSQKIQDRIIMAMIWVVAALVIALVVGTALNYINI FK*" /label="yuzG CDS" gene complement(2953737..2953877) /gene="yuzG" /locus_tag="BSU_32120" /old_locus_tag="BSU32120" /label="yuzG gene" downshifts complement(2953749) /Source="Nicolas_upshifts" /id="D1664" /incds=0 /nref=61 /ntot=234 /MaxReadThrough="1.27572" /MaxDrop="5.65243" /score="32.0354025" /energy="-12.8" /TU="NA" /idTUdmin="U2515" /TUdmin=1 /isTUend="TRUE" /label="downshifts" S_feature complement(2953878..2954007) /Source="Nicolas_S_feature" /locus_tag="new_3302764_3302893_c" /HighExp="dia15, Salt, Cold, Diami, H2O2, Etha, GM 15, dia5, MG-0.2, MG t5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.36371900000000001" /TUshortSig="SigA, SigGF" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1240" promotor_-10 complement(2953988..2954007) /Source="Nicolas_upshift_promotors" /id="U2513" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.344655344655345" /psig="0.999000999001" /xcortree=1851 /SigmaFactorBS="aacattatgatttgctggcaggtgtggtgcaagtgccgaaGC TTGTCatgcagggtgagtTTAGGTATCATAGTTTTAACgaatggtcttagagagcgga t" /listShort="S1240, yuzG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2954007) /Source="Nicolas_upshifts" /id="U2513" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.344655344655345" /psig="0.999000999001" /xcortree=1851 /SigmaFactorBS="aacattatgatttgctggcaggtgtggtgcaagtgccgaaGC TTGTCatgcagggtgagtTTAGGTATCATAGTTTTAACgaatggtcttagagagcgga t" /listShort="S1240, yuzG" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2954009..2954256) /Source="Nicolas_S_feature" /locus_tag="new_3302895_3303142_c" /HighExp="S8, S5, S6, S7, S4, ferm, nit, C30, Pyr, T5.0H" /AntisenseName="guaC" /AntisenseCor="-0.291283195124732" /AntisenseRegPval="-5.9" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1241" promotor_-35 complement(2954021..2954027) /Source="Nicolas_upshift_promotors" /id="U2513" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.344655344655345" /psig="0.999000999001" /xcortree=1851 /SigmaFactorBS="aacattatgatttgctggcaggtgtggtgcaagtgccgaaGC TTGTCatgcagggtgagtTTAGGTATCATAGTTTTAACgaatggtcttagagagcgga t" /listShort="S1240, yuzG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2954064..2954071 /Source="Nicolas_upshift_promotors" /id="U2514" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.518481518481518" /psig="0.998001998001998" /xcortree=2630 /SigmaFactorBS="cacttgcaccacacctgccagcaaatcataaTGTTTGACatc ctaaataaaaCAGAGTACATTATATAAGGCgaacatttcatatattatacttttaaat a" /listShort="guaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2954085..2954104 /Source="Nicolas_upshift_promotors" /id="U2514" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.518481518481518" /psig="0.998001998001998" /xcortree=2630 /SigmaFactorBS="cacttgcaccacacctgccagcaaatcataaTGTTTGACatc ctaaataaaaCAGAGTACATTATATAAGGCgaacatttcatatattatacttttaaat a" /listShort="guaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2954093 /Source="Nicolas_upshifts" /id="U2514" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.518481518481518" /psig="0.998001998001998" /xcortree=2630 /SigmaFactorBS="cacttgcaccacacctgccagcaaatcataaTGTTTGACatc ctaaataaaaCAGAGTACATTATATAAGGCgaacatttcatatattatacttttaaat a" /listShort="guaC" /GFF_Attribute="listLong" /label="upshifts" CDS 2954156..2955136 /gene="guaC" /locus_tag="BSU_32130" /old_locus_tag="BSU32130" /EC_number="1.7.1.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:6408059, 11591660, 6408059" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6408059, 11591660, 6408059; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="GMP reductase (NADP-dependent)" /protein_id="NP_391093.2" /db_xref="EnsemblGenomes-Gn:BSU32130" /db_xref="EnsemblGenomes-Tr:CAB15203" /db_xref="GOA:O05269" /db_xref="InterPro:IPR001093" /db_xref="InterPro:IPR005994" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR015875" /db_xref="SubtiList:BG12392" /db_xref="UniProtKB/Swiss-Prot:O05269" /translation="MENVFDYEDIQLIPAKCIVNSRSECDTSVRLGGHTFKLPVVPAN MQTIIDEKLAISLAENGYFYVMHRFEPETRIDFIKDMNARGLFSSISVGVKDEEYEFV RQLAEENLTPEYVTIDIAHGHSNAVIEMIQHLKKHLPDSFVIAGNVGTPEAVRELENA GADATKVGIGPGKVCITKIKTGFGTGGWQLAALRWCAKAASKPIIADGGIRTHGDIAK SIRFGATMVMIGSLFAGHEESPGQTIEKDGKLYKEYFGSASEFQKGEKKNVEGKKMHV AHKGSIKDTLIEMEQDLQSSISYAGGTKLNAIRNVDYVIVKNSIFNGDKY*" /label="guaC CDS" gene 2954156..2955136 /gene="guaC" /locus_tag="BSU_32130" /old_locus_tag="BSU32130" /label="guaC gene" upshifts complement(2954257) /Source="Nicolas_upshifts" /id="U2515" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=853 /SigmaFactorBS="cgctagtttttcatctataatcgtcTGCATATtggcagggac gacGGGCAATTTAAAtgtatgtccgcctaaacgtacggatgtatcacattctgaacgg c" /listShort="S1241, S1240, yuzG" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2954261..2954272) /Source="Nicolas_upshift_promotors" /id="U2515" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=853 /SigmaFactorBS="cgctagtttttcatctataatcgtcTGCATATtggcagggac gacGGGCAATTTAAAtgtatgtccgcctaaacgtacggatgtatcacattctgaacgg c" /listShort="S1241, S1240, yuzG" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2954286..2954292) /Source="Nicolas_upshift_promotors" /id="U2515" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=853 /SigmaFactorBS="cgctagtttttcatctataatcgtcTGCATATtggcagggac gacGGGCAATTTAAAtgtatgtccgcctaaacgtacggatgtatcacattctgaacgg c" /listShort="S1241, S1240, yuzG" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2955104 /Source="Nicolas_upshifts" /id="D1665" /incds=0 /nref=91 /ntot=186 /MaxReadThrough="1.24882" /MaxDrop="7.43286" /score="-2.82053244" /energy="-16.2" /TU="NA" /idTUdmin="U2514" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(2955209) /Source="Nicolas_upshifts" /id="D1666" /incds=0 /nref=24 /ntot=212 /MaxReadThrough="1.15696" /MaxDrop="6.12198" /score="23.834956" /energy="-16.2" /TU="NA" /idTUdmin="U2517" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" CDS complement(2955210..2955833) /gene="paiB" /locus_tag="BSU_32140" /old_locus_tag="BSU32140" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 16210326, 21633969; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="transcriptional regulator (regulates paiA expression)" /protein_id="NP_391094.2" /db_xref="EnsemblGenomes-Gn:BSU32140" /db_xref="EnsemblGenomes-Tr:CAB15204" /db_xref="GOA:P21341" /db_xref="InterPro:IPR007396" /db_xref="InterPro:IPR012349" /db_xref="SubtiList:BG10696" /db_xref="UniProtKB/Swiss-Prot:P21341" /translation="MYIPKYFKVTNAEEIWNFVQENSFGTVVTTEQGKPIATHLPLGF NKKDDHYYITGHFAYGNPQWRTFEACEDVLVMFQGPHAYISSSWYSRENVPTWNYQAV HMYGKASMLEKDELAEELTIMLEKYEKHRDNPVLWDKLSPKLLESELKGIVGFKIKVE DIQAAYKLSQNRNETDYMNVIEQLQNEENPNAKQMAELMEDKLKKQI*" /label="paiB CDS" gene complement(2955210..2955833) /gene="paiB" /locus_tag="BSU_32140" /old_locus_tag="BSU32140" /label="paiB gene" CDS complement(2955857..2956375) /gene="paiA" /locus_tag="BSU_32150" /old_locus_tag="BSU32150" /EC_number="2.3.1.57" /function="16.6: Maintain" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16210326, 17588214, 21633970, 26818562, 28546427" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16210326, 17588214, 21633970, 26818562, 28546427; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="polyamine N-acetyltransferase" /protein_id="NP_391095.1" /db_xref="EnsemblGenomes-Gn:BSU32150" /db_xref="EnsemblGenomes-Tr:CAB15205" /db_xref="GOA:P21340" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="PDB:1TIQ" /db_xref="SubtiList:BG10695" /db_xref="UniProtKB/Swiss-Prot:P21340" /translation="MSVKMKKCSREDLQTLQQLSIETFNDTFKEQNSPENMKAYLESA FNTEQLEKELSNMSSQFFFIYFDHEIAGYVKVNIDDAQSEEMGAESLEIERIYIKNSF QKHGLGKHLLNKAIEIALERNKKNIWLGVWEKNENAIAFYKKMGFVQTGAHSFYMGDE EQTDLIMAKTLI*" /label="paiA CDS" gene complement(2955857..2956375) /gene="paiA" /locus_tag="BSU_32150" /old_locus_tag="BSU32150" /label="paiA gene" misc_feature complement(2956422..2956441) /Source="Nicolas_upshift_promotors" /id="U2516" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.719280719280719" /psig="0.937062937062937" /xcortree=2765 /SigmaFactorBS="ggagttggtgatgaagaagatttttggaatggtaacaaggtc agtatgtgttcCGTGTTTAAATATATAAAAGggacacaagacaattgaattttaaata a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2956434) /Source="Nicolas_upshifts" /id="U2516" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.719280719280719" /psig="0.937062937062937" /xcortree=2765 /SigmaFactorBS="ggagttggtgatgaagaagatttttggaatggtaacaaggtc agtatgtgttcCGTGTTTAAATATATAAAAGggacacaagacaattgaattttaaata a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2956436..2956544) /Source="Nicolas_S_feature" /locus_tag="new_3305322_3305430_c" /HighExp="LoTm, HiTm, G135, Salt, G180, Cold, LBGstat, T0.0H, B36, T-2.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1242" promotor_-10 complement(2956531..2956548) /Source="Nicolas_upshift_promotors" /id="U2517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.698301698301698" /psig=1 /xcortree=1782 /SigmaFactorBS="gcaagagaaacgctgctttgttgtttgattttTGTTGTAAat acagcaaagttaCGATATATTTAATGCGGAgtatattttattgcatttacaacaaaat c" /listShort="S1242, paiA, paiB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2956542) /Source="Nicolas_upshifts" /id="U2517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.698301698301698" /psig=1 /xcortree=1782 /SigmaFactorBS="gcaagagaaacgctgctttgttgtttgattttTGTTGTAAat acagcaaagttaCGATATATTTAATGCGGAgtatattttattgcatttacaacaaaat c" /listShort="S1242, paiA, paiB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2956563..2956570) /Source="Nicolas_upshift_promotors" /id="U2517" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.698301698301698" /psig=1 /xcortree=1782 /SigmaFactorBS="gcaagagaaacgctgctttgttgtttgattttTGTTGTAAat acagcaaagttaCGATATATTTAATGCGGAgtatattttattgcatttacaacaaaat c" /listShort="S1242, paiA, paiB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(2956698) /Source="Nicolas_upshifts" /id="D1667" /incds=0 /nref=267 /ntot=269 /MaxReadThrough="1.56881" /MaxDrop="8.24828" /score="12.6937405" /energy="-18.7" /TU="NA" /idTUdmin="U2518" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2956713..2957075) /gene="sufA" /locus_tag="BSU_32160" /old_locus_tag="BSU32160" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17698959, 19478995, 20097860, 25447545; Product type c: carrier" /codon_start=1 /transl_table=11 /product="sulfur carrier chaperone involved in Fe-S cluster assembly" /protein_id="NP_391096.1" /db_xref="EnsemblGenomes-Gn:BSU32160" /db_xref="EnsemblGenomes-Tr:CAB15206" /db_xref="GOA:O32113" /db_xref="InterPro:IPR000361" /db_xref="InterPro:IPR016092" /db_xref="InterPro:IPR017870" /db_xref="InterPro:IPR035903" /db_xref="SubtiList:BG14049" /db_xref="UniProtKB/Swiss-Prot:O32113" /translation="MSNPVTITEAAALHIKDMMKEHEEENAFLRVGVKGGGCSGLSYG MGFEHEKSESDSVFDQHGITVLVDKESLDIMNGTVIDYKQSMLGGGFTIDNPNAIASC GCGSSFRTATNAGKPEEC*" /label="sufA CDS" gene complement(2956713..2957075) /gene="sufA" /locus_tag="BSU_32160" /old_locus_tag="BSU32160" /label="sufA gene" promotor_-10 complement(2957106..2957125) /Source="Nicolas_upshift_promotors" /id="U2518" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.765234765234765" /psig=1 /xcortree=2038 /SigmaFactorBS="gtgagggtgtctatttcttgtaaaacacctTGTTTGAGaatt ggaacgatcATGTTTATAATAAAAGACAGcaaccggtttttaaaaggaggttcataat g" /listShort="yutM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2957116) /Source="Nicolas_upshifts" /id="U2518" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.765234765234765" /psig=1 /xcortree=2038 /SigmaFactorBS="gtgagggtgtctatttcttgtaaaacacctTGTTTGAGaatt ggaacgatcATGTTTATAATAAAAGACAGcaaccggtttttaaaaggaggttcataat g" /listShort="yutM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2957139..2957146) /Source="Nicolas_upshift_promotors" /id="U2518" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.765234765234765" /psig=1 /xcortree=2038 /SigmaFactorBS="gtgagggtgtctatttcttgtaaaacacctTGTTTGAGaatt ggaacgatcATGTTTATAATAAAAGACAGcaaccggtttttaaaaggaggttcataat g" /listShort="yutM" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2957154..2958008) /gene="dapF" /locus_tag="BSU_32170" /old_locus_tag="BSU32170" /EC_number="5.1.1.7" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 14627808, 16723397, 19307721, 28873470; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="diaminopimelate epimerase" /protein_id="NP_391097.1" /db_xref="EnsemblGenomes-Gn:BSU32170" /db_xref="EnsemblGenomes-Tr:CAB15207" /db_xref="GOA:O32114" /db_xref="InterPro:IPR001653" /db_xref="InterPro:IPR018510" /db_xref="SubtiList:BG14048" /db_xref="UniProtKB/Swiss-Prot:O32114" /translation="MNSFRFTKMHGLGNSYIYVNQFEEQLPEEKLSEIAIQVSSVYTG IGSDGMILICPSDQAPVKMRIFNNDGSEGKNCGNGLRCVAKYAYEHKLVEETSFLIET LSGLVKAEVQVENGKVNVVTVDMGEPRLTKSELPMLDGGEEHTINETMAFGEVELTGT AVSMGNPHIVFPIADIEQAPLTTLGPVIEKDPRFPEGINVEFVETVNEQELHFRVWER GSGITQACGTGACAAAVASVLNGVSKRNQDITVHLAGGDLVINWKDNGHVMMTGPAET VCEGVYFL*" /label="dapF CDS" gene complement(2957154..2958008) /gene="dapF" /locus_tag="BSU_32170" /old_locus_tag="BSU32170" /label="dapF gene" promotor_-10 complement(2957724..2957743) /Source="Nicolas_upshift_promotors" /id="U2519" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1232 /SigmaFactorBS="gggaaaaactgcggcaacggcctgcgcTGCGTCGCAAaatac gcatatgAGCATAAGCTGGTTGAGGAAacatcttttctgattgaaactctctccgggc t" /listShort="yutM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2957732) /Source="Nicolas_upshifts" /id="U2519" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1232 /SigmaFactorBS="gggaaaaactgcggcaacggcctgcgcTGCGTCGCAAaatac gcatatgAGCATAAGCTGGTTGAGGAAacatcttttctgattgaaactctctccgggc t" /listShort="yutM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2957756..2957765) /Source="Nicolas_upshift_promotors" /id="U2519" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1232 /SigmaFactorBS="gggaaaaactgcggcaacggcctgcgcTGCGTCGCAAaatac gcatatgAGCATAAGCTGGTTGAGGAAacatcttttctgattgaaactctctccgggc t" /listShort="yutM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(2958030..2958049) /Source="Nicolas_upshift_promotors" /id="U2520" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.843156843156843" /psig="0.999000999001" /xcortree=2385 /SigmaFactorBS="aaggagcttttatgtatgaaaaacgggggataattgtATTGt gtccgcttataatAGCTTTTATACTAAGAAAAAgaaaaaaagttggaggcacctatga a" /listShort="dapF, yutM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2958044) /Source="Nicolas_upshifts" /id="U2520" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.843156843156843" /psig="0.999000999001" /xcortree=2385 /SigmaFactorBS="aaggagcttttatgtatgaaaaacgggggataattgtATTGt gtccgcttataatAGCTTTTATACTAAGAAAAAgaaaaaaagttggaggcacctatga a" /listShort="dapF, yutM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2958064..2958067) /Source="Nicolas_upshift_promotors" /id="U2520" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.843156843156843" /psig="0.999000999001" /xcortree=2385 /SigmaFactorBS="aaggagcttttatgtatgaaaaacgggggataattgtATTGt gtccgcttataatAGCTTTTATACTAAGAAAAAgaaaaaaagttggaggcacctatga a" /listShort="dapF, yutM" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2958131..2959345) /gene="yutK" /locus_tag="BSU_32180" /old_locus_tag="BSU32180" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative Na+(H+)/nucleoside cotransporter" /protein_id="NP_391098.1" /db_xref="EnsemblGenomes-Gn:BSU32180" /db_xref="EnsemblGenomes-Tr:CAB15208" /db_xref="GOA:O32115" /db_xref="InterPro:IPR002668" /db_xref="InterPro:IPR008276" /db_xref="InterPro:IPR011657" /db_xref="InterPro:IPR018270" /db_xref="SubtiList:BG14047" /db_xref="UniProtKB/Swiss-Prot:O32115" /translation="MNVLWGLLGAVAIIAIAFLFSEKKSNIKIRTVIVGLCTQVAFGY IVLKWEAGRAVFLWFSSRVQLLIDYANEGISFIFGPLLKVGDSPAFALSVLPVIIFFS ALIAVLYHLKIMQLVFRVIGGGLSKLLGTSKTESLAAAANIFVGQSESPLVIKPLIAG LTRSELFTIMTSGLSAVAGSTLFGYALLGIPIEYLLAASFMAAPAGLVFGKLIIPETE KTQTVKSDFKMDEGEGAANVIDAAAKGASTGLQIALNVGAMLLAFVALIAVVNGILGG AFGLFGLKGVTLESILGYVFSPIAFLIGVPWHEALQAGSYIGQKLVLNEFVAYSNFGS HIGEFSKKTATIISFALCGFANFSSIAIMLGTLGGLAPSRRSDIARLGLKAVLAGTLA NLLSAAIAGMFI*" /label="yutK CDS" gene complement(2958131..2959345) /gene="yutK" /locus_tag="BSU_32180" /old_locus_tag="BSU32180" /label="yutK gene" promotor_-35 2958680..2958686 /Source="Nicolas_upshift_promotors" /id="U2521" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=205 /SigmaFactorBS="tcgccttcatccattttgaaatcgctttttacGGTTTGCgtt ttttccgtttcGGGTATAATCAATTTACCAaagactagtccagctggagcagccataa a" /listShort="S1243, S1244, yutJ" /listLong="yutI" /label="promotor_-35" promotor_-10 2958701..2958719 /Source="Nicolas_upshift_promotors" /id="U2521" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=205 /SigmaFactorBS="tcgccttcatccattttgaaatcgctttttacGGTTTGCgtt ttttccgtttcGGGTATAATCAATTTACCAaagactagtccagctggagcagccataa a" /listShort="S1243, S1244, yutJ" /listLong="yutI" /label="promotor_-10" upshifts 2958708 /Source="Nicolas_upshifts" /id="U2521" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=205 /SigmaFactorBS="tcgccttcatccattttgaaatcgctttttacGGTTTGCgtt ttttccgtttcGGGTATAATCAATTTACCAaagactagtccagctggagcagccataa a" /listShort="S1243, S1244, yutJ" /listLong="yutI" /label="upshifts" S_feature 2958712..2959481 /Source="Nicolas_S_feature" /locus_tag="new_3307598_3308367" /HighExp="Etha, Salt, Gly, M9-stat, Sw, LoTm, B60, BC, Heat, S0" /AntisenseName="yutK" /AntisenseCor="-0.36240965013078302" /AntisenseRegPval="-9" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1243" promotor_-10 complement(2959382..2959401) /Source="Nicolas_upshift_promotors" /id="U2522" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.924075924075924" /psig="0.998001998001998" /xcortree=2478 /SigmaFactorBS="ccgtacaaaagaactaaaaaaatgTGTAGACAtcaaaaaata ttatTGTTATCGTATAAAAGATATttttttaaataaaatttaagaggtgtacgagtat t" /listShort="yutK" /listLong="dapF, yutM" /label="promotor_-10" upshifts complement(2959387) /Source="Nicolas_upshifts" /id="U2522" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.924075924075924" /psig="0.998001998001998" /xcortree=2478 /SigmaFactorBS="ccgtacaaaagaactaaaaaaatgTGTAGACAtcaaaaaata ttatTGTTATCGTATAAAAGATATttttttaaataaaatttaagaggtgtacgagtat t" /listShort="yutK" /listLong="dapF, yutM" /label="upshifts" promotor_-35 complement(2959416..2959423) /Source="Nicolas_upshift_promotors" /id="U2522" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.924075924075924" /psig="0.998001998001998" /xcortree=2478 /SigmaFactorBS="ccgtacaaaagaactaaaaaaatgTGTAGACAtcaaaaaata ttatTGTTATCGTATAAAAGATATttttttaaataaaatttaagaggtgtacgagtat t" /listShort="yutK" /listLong="dapF, yutM" /label="promotor_-35" downshifts 2959438 /Source="Nicolas_upshifts" /id="D1668" /incds=0 /nref=3 /ntot=58 /MaxReadThrough="4.13852" /MaxDrop="3.94079" /score="20.5760616" /energy="-10.5" /TU="U2521" /idTUdmin="U2521" /TUdmin="-1913" /isTUend="FALSE" /label="downshifts" CDS complement(2959482..2959718) /gene="yuzB" /locus_tag="BSU_32190" /old_locus_tag="BSU32190" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391099.1" /db_xref="EnsemblGenomes-Gn:BSU32190" /db_xref="EnsemblGenomes-Tr:CAB15209" /db_xref="InterPro:IPR009910" /db_xref="InterPro:IPR022916" /db_xref="SubtiList:BG14051" /db_xref="UniProtKB/Swiss-Prot:O32116" /translation="MNPMIEFCVSNLAHGSQEARAILEKDPNLDVLEYGCLSYCGTCM ESLFALVNGEVVMGETPAELVENIYTFIEENPMF*" /label="yuzB CDS" gene complement(2959482..2959718) /gene="yuzB" /locus_tag="BSU_32190" /old_locus_tag="BSU32190" /label="yuzB gene" S_feature 2959483..2959899 /Source="Nicolas_S_feature" /locus_tag="new_3308369_3308785" /HighExp="Salt, LoTm, Gly, Etha, Sw, Heat, S0, C30, M9-stat, Mal" /AntisenseName="yuzB" /AntisenseCor="-5.6824456709843603E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1244" downshifts complement(2959500) /Source="Nicolas_upshifts" /id="D1669" /incds=0 /nref=175 /ntot=239 /MaxReadThrough="1.28789" /MaxDrop="7.32368" /score="41.4640292" /energy="-10.5" /TU="NA" /idTUdmin="U2523" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2959683..2959684) /Source="Nicolas_upshift_promotors" /id="U2523" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.276723276723277" /psig="0.122877122877123" /xcortree=3156 /SigmaFactorBS="cgcgataatggacatatgtgaggtgaaaccgcatgaatccaa tgattgaattttgtgtCAGCAatcTGgctcacggctctcaggaagcccgggcgatttt g" /listShort="yuzB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2959688..2959692) /Source="Nicolas_upshift_promotors" /id="U2523" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.276723276723277" /psig="0.122877122877123" /xcortree=3156 /SigmaFactorBS="cgcgataatggacatatgtgaggtgaaaccgcatgaatccaa tgattgaattttgtgtCAGCAatcTGgctcacggctctcaggaagcccgggcgatttt g" /listShort="yuzB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(2959690) /Source="Nicolas_upshifts" /id="U2523" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.276723276723277" /psig="0.122877122877123" /xcortree=3156 /SigmaFactorBS="cgcgataatggacatatgtgaggtgaaaccgcatgaatccaa tgattgaattttgtgtCAGCAatcTGgctcacggctctcaggaagcccgggcgatttt g" /listShort="yuzB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2959733..2959752) /Source="Nicolas_upshift_promotors" /id="U2524" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2043 /SigmaFactorBS="taaattttgaatcatccgttgTCTTTGACgaatagtgaaaaa TTCGCGATAATGGACATATGtgaggtgaaaccgcatgaatccaatgattgaattttgt g" /listShort="yuzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2959734) /Source="Nicolas_upshifts" /id="U2524" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2043 /SigmaFactorBS="taaattttgaatcatccgttgTCTTTGACgaatagtgaaaaa TTCGCGATAATGGACATATGtgaggtgaaaccgcatgaatccaatgattgaattttgt g" /listShort="yuzB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2959766..2959773) /Source="Nicolas_upshift_promotors" /id="U2524" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2043 /SigmaFactorBS="taaattttgaatcatccgttgTCTTTGACgaatagtgaaaaa TTCGCGATAATGGACATATGtgaggtgaaaccgcatgaatccaatgattgaattttgt g" /listShort="yuzB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2959876..2959881 /Source="Nicolas_upshift_promotors" /id="U2525" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.35964035964036" /psig=1 /xcortree=2314 /SigmaFactorBS="tttcaggctaaattgtaggttattttgaaactattATTGTGa ttttagatcaaaTTCGATATAATTCTAGATGTtattttacatagttcgtattttcttc a" /listShort="yutJ" /listLong="yutI" /label="promotor_-35" promotor_-10 2959895..2959914 /Source="Nicolas_upshift_promotors" /id="U2525" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.35964035964036" /psig=1 /xcortree=2314 /SigmaFactorBS="tttcaggctaaattgtaggttattttgaaactattATTGTGa ttttagatcaaaTTCGATATAATTCTAGATGTtattttacatagttcgtattttcttc a" /listShort="yutJ" /listLong="yutI" /label="promotor_-10" upshifts 2959901 /Source="Nicolas_upshifts" /id="U2525" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.35964035964036" /psig=1 /xcortree=2314 /SigmaFactorBS="tttcaggctaaattgtaggttattttgaaactattATTGTGa ttttagatcaaaTTCGATATAATTCTAGATGTtattttacatagttcgtattttcttc a" /listShort="yutJ" /listLong="yutI" /label="upshifts" CDS 2959981..2961048 /gene="yutJ" /locus_tag="BSU_32200" /old_locus_tag="BSU32200" /EC_number="1.6.-.-" /function="16.10: Respire" /function="16.7: Manage energy" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17015645; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative NADH dehydrogenase" /protein_id="NP_391100.2" /db_xref="EnsemblGenomes-Gn:BSU32200" /db_xref="EnsemblGenomes-Tr:CAB15210" /db_xref="GOA:O32117" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG14046" /db_xref="UniProtKB/Swiss-Prot:O32117" /translation="MKKLVLIGGGYGNMRVLHRLLPNQLPDDVSITLIDRNPYHCLKT EYYALAAGTISDHHIRVSFPEHPRLDVQYGDITSIDIVQKQVLFQDREPISYDDAIIG LGCEDKYHNVPGAPEFTYSIQTIDQSRETYQKLNNLSANATVAIVGAGLSGVELASEL RESRDDLNIILFDRGNLILSSFPERLSKYVQKWFEEHGVRIINRANITKVEEGVVYNH DDPISADAIVWTAGIQPNKVVRDLDVEKDAQGRIVLTPHHNLPGDEHLYVVGDCASLP HAPSAQLAEAQAEQIVQILQKRWNGEALPESMPQFKLKGVLGSLGKKAGFGLVADRPL IGRVPRMLKSGLLWMYKHHNG*" /label="yutJ CDS" gene 2959981..2961048 /gene="yutJ" /locus_tag="BSU_32200" /old_locus_tag="BSU32200" /label="yutJ gene" downshifts 2961032 /Source="Nicolas_upshifts" /id="D1670" /incds=0 /nref=4 /ntot=110 /MaxReadThrough="3.51945" /MaxDrop="3.02708" /score="6.15657679" /energy="-10.8" /TU="U2521,U2525" /idTUdmin="U2521" /TUdmin="-319" /isTUend="FALSE" /label="downshifts" CDS complement(2961074..2961400) /gene="yuzD" /locus_tag="BSU_32210" /old_locus_tag="BSU32210" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11551182; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sulfur oxido-reduction management enzyme" /protein_id="NP_391101.1" /db_xref="EnsemblGenomes-Gn:BSU32210" /db_xref="EnsemblGenomes-Tr:CAB15211" /db_xref="InterPro:IPR009190" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG14053" /db_xref="UniProtKB/Swiss-Prot:O32118" /translation="MMKPVMLSVYGAENVCASCVNMPTAKDTYEWLEAALKRKYPNQP FEMQYIDIHEPPDNEHAKELAEKIRNDEYFYPLVLVEDKIVGEGNPKLKDVYEEMEKH GYTENR*" /label="yuzD CDS" gene complement(2961074..2961400) /gene="yuzD" /locus_tag="BSU_32210" /old_locus_tag="BSU32210" /label="yuzD gene" downshifts complement(2961097) /Source="Nicolas_upshifts" /id="D1671" /incds=0 /nref=4 /ntot=180 /MaxReadThrough="1.63835" /MaxDrop="3.17377" /score="-8.05690984" /energy="-10.8" /TU="NA" /idTUdmin="U2526" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2961432..2961451) /Source="Nicolas_upshift_promotors" /id="U2526" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.507492507492508" /psig="0.995004995004995" /xcortree=2229 /SigmaFactorBS="tatagcacattcagacttcaacacaaaaacggttttttTCTA TAAAaacgcccttaggCTCTGTATACTTAAAAGAAAggacttacataggagaaggggg c" /listShort="yuzD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2961449) /Source="Nicolas_upshifts" /id="U2526" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.507492507492508" /psig="0.995004995004995" /xcortree=2229 /SigmaFactorBS="tatagcacattcagacttcaacacaaaaacggttttttTCTA TAAAaacgcccttaggCTCTGTATACTTAAAAGAAAggacttacataggagaaggggg c" /listShort="yuzD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2961464..2961471) /Source="Nicolas_upshift_promotors" /id="U2526" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.507492507492508" /psig="0.995004995004995" /xcortree=2229 /SigmaFactorBS="tatagcacattcagacttcaacacaaaaacggttttttTCTA TAAAaacgcccttaggCTCTGTATACTTAAAAGAAAggacttacataggagaaggggg c" /listShort="yuzD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2961484..2961488 /Source="Nicolas_upshift_promotors" /id="U2527" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=593 /SigmaFactorBS="acagagcctaagggcgtttttatagaaaaaaaccgtttTTGT GttgaagtctgaaTGTGCTATAATAGGGAAAGCaactttgcaaaccaaacaatagatt t" /listShort="yutI" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2961500..2961835 /gene="yutI" /locus_tag="BSU_32220" /old_locus_tag="BSU32220" /function="16.6: Maintain" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17237162, 21749987; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative iron-sulfur scaffold protein" /protein_id="NP_391102.1" /db_xref="EnsemblGenomes-Gn:BSU32220" /db_xref="EnsemblGenomes-Tr:CAB15212" /db_xref="GOA:O32119" /db_xref="InterPro:IPR001075" /db_xref="InterPro:IPR034904" /db_xref="SubtiList:BG14045" /db_xref="UniProtKB/Swiss-Prot:O32119" /translation="MCYNRESNFANQTIDFYCYTEYNGFMTTKGANVMTEVEMKEQVQ EVLDKLRPFLLRDGGDCELVDVDEGIVKLRLLGACGSCPSSTITLKAGIERALLEEVP GVVEVEQVF*" /label="yutI CDS" gene 2961500..2961835 /gene="yutI" /locus_tag="BSU_32220" /old_locus_tag="BSU32220" /label="yutI gene" promotor_-10 2961501..2961520 /Source="Nicolas_upshift_promotors" /id="U2527" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=593 /SigmaFactorBS="acagagcctaagggcgtttttatagaaaaaaaccgtttTTGT GttgaagtctgaaTGTGCTATAATAGGGAAAGCaactttgcaaaccaaacaatagatt t" /listShort="yutI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2961506 /Source="Nicolas_upshifts" /id="U2527" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=593 /SigmaFactorBS="acagagcctaagggcgtttttatagaaaaaaaccgtttTTGT GttgaagtctgaaTGTGCTATAATAGGGAAAGCaactttgcaaaccaaacaatagatt t" /listShort="yutI" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(2961625) /Source="Nicolas_upshifts" /id="D1672" /incds=1 /nref=1 /ntot=5 /MaxReadThrough="1.28655" /MaxDrop="3.45909" /score="7.3681553" /energy="-21.2" /TU="NA" /idTUdmin="U2528" /TUdmin=264 /isTUend="FALSE" /label="downshifts" downshifts 2961813 /Source="Nicolas_upshifts" /id="D1673" /incds=0 /nref=258 /ntot=281 /MaxReadThrough="3.6035" /MaxDrop="7.98922" /score="39.7008566" /energy="-19.5" /TU="U2527" /idTUdmin="U2527" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" CDS complement(2961877..2963850) /gene="yuxL" /locus_tag="BSU_32230" /old_locus_tag="BSU32230" /EC_number="3.4.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8576092, 11406580; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acylaminoacyl-peptidase" /protein_id="NP_391103.2" /db_xref="EnsemblGenomes-Gn:BSU32230" /db_xref="EnsemblGenomes-Tr:CAB15213" /db_xref="GOA:P39839" /db_xref="InterPro:IPR001375" /db_xref="InterPro:IPR011659" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG10463" /db_xref="UniProtKB/Swiss-Prot:P39839" /translation="MKKLITADDITAIVSVTDPQYAPDGTRAAYVKSQVNQEKDSYTS NIWIYETKTGGSVPWTHGEKRSTDPRWSPDGRTLAFISDREGDAAQLYIMSTEGGEAR KLTDIPYGVSKPLWSPDGESILVTVSLGEGESIDDREKTEQDSYEPVEVQGLSYKRDG KGLTRGAYAQLVLVSVKSGEMKELTSHKADHGDPAFSPDGKWLVFSANLTETDDASKP HDVYIMSLESGDLKQVTPHRGSFGSSSFSPDGRYLALLGNEKEYKNATLSKAWLYDIE QGRLTCLTEMLDVHLADALIGDSLIGGAEQRPIWTKDSQGFYVIGTDQGSTGIYYISI EGLVYPIRLEKEYINSFSLSPDEQHFIASVTKPDRPSELYSIPLGQEEKQLTGANDKF VREHTISIPEEIQYATEDGVMVNGWLMRPAQMEGETTYPLILNIHGGPHMMYGHTYFH EFQVLAAKGYAVVYINPRGSHGYGQEFVNAVRGDYGGKDYDDVMQAVDEAIKRDPHID PKRLGVTGGSYGGFMTNWIVGQTNRFKAAVTQRSISNWISFHGVSDIGYFFTDWQLEH DMFEDTEKLWDRSPLKYAANVETPLLILHGERDDRCPIEQAEQLFIALKKMGKETKLV RFPNASHNLSRTGHPRQRIKRLNYISSWFDQHL*" /label="yuxL CDS" gene complement(2961877..2963850) /gene="yuxL" /locus_tag="BSU_32230" /old_locus_tag="BSU32230" /label="yuxL gene" downshifts complement(2961889) /Source="Nicolas_upshifts" /id="D1674" /incds=0 /nref=19 /ntot=114 /MaxReadThrough="1.79797" /MaxDrop="3.85507" /score="7.3681553" /energy="-21.2" /TU="NA" /idTUdmin="U2528" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2963865..2963883) /Source="Nicolas_upshift_promotors" /id="U2528" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=501 /SigmaFactorBS="agcgttcctcagcgtcagcggagggcgcttttttttgctgga gatAAAGGAGTTtttatttagaaAAACGAAATACATGTAAAAaggaggagatgaatat g" /listShort="yuxL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2963888) /Source="Nicolas_upshifts" /id="U2528" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=501 /SigmaFactorBS="agcgttcctcagcgtcagcggagggcgcttttttttgctgga gatAAAGGAGTTtttatttagaaAAACGAAATACATGTAAAAaggaggagatgaatat g" /listShort="yuxL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2963895..2963903) /Source="Nicolas_upshift_promotors" /id="U2528" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=501 /SigmaFactorBS="agcgttcctcagcgtcagcggagggcgcttttttttgctgga gatAAAGGAGTTtttatttagaaAAACGAAATACATGTAAAAaggaggagatgaatat g" /listShort="yuxL" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2963958..2964887) /gene="thrB" /locus_tag="BSU_32240" /old_locus_tag="BSU32240" /EC_number="2.7.1.39" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:3098560, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3098560, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="homoserine kinase" /protein_id="NP_391104.1" /db_xref="EnsemblGenomes-Gn:BSU32240" /db_xref="EnsemblGenomes-Tr:CAB15214" /db_xref="GOA:P04948" /db_xref="InterPro:IPR000870" /db_xref="InterPro:IPR006203" /db_xref="InterPro:IPR006204" /db_xref="InterPro:IPR013750" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR036554" /db_xref="SubtiList:BG10462" /db_xref="UniProtKB/Swiss-Prot:P04948" /translation="MNEADMLFSVTVPGSTANLGPGFDSVGMALSRYLKLTVFESDKW SFEAETETVAGIPAGTDNLIYQVAKRTADLYGKEMPPVHVKVWSDIPLARGLGSSAAA IVAAIELADELCGLKLSEADKLHLASLEEGHPDNAGASLVGGLVIGLHEDDETQMIRV PNADIDVVVVIPFYEVLTRDARDVLPKEFPYADAVKASAVSNILIAAIMSKDWPLVGK IMKKDMFHQPYRAMLVPELSKVEHVAEMKGAYGTALSGAGPTILVMTEKGKGEELKEQ LALHFPHCEVDALTVPKEGSIIERNPLYQVKSV*" /label="thrB CDS" gene complement(2963958..2964887) /gene="thrB" /locus_tag="BSU_32240" /old_locus_tag="BSU32240" /label="thrB gene" downshifts complement(2963971) /Source="Nicolas_upshifts" /id="D1675" /incds=0 /nref=222 /ntot=261 /MaxReadThrough="2.39521" /MaxDrop="7.03759" /score="15.5945196" /energy="-10.3" /TU="NA" /idTUdmin="U2530" /TUdmin="-14" /isTUend="TRUE" /label="downshifts" CDS complement(2964884..2965942) /gene="thrC" /locus_tag="BSU_32250" /old_locus_tag="BSU32250" /EC_number="4.2.3.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:3098560, 3139660, 8768250" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3098560, 3139660, 8768250; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="threonine synthase" /protein_id="NP_391105.1" /db_xref="EnsemblGenomes-Gn:BSU32250" /db_xref="EnsemblGenomes-Tr:CAB15215" /db_xref="GOA:P04990" /db_xref="InterPro:IPR000634" /db_xref="InterPro:IPR001926" /db_xref="InterPro:IPR004450" /db_xref="InterPro:IPR026260" /db_xref="InterPro:IPR036052" /db_xref="SubtiList:BG10461" /db_xref="UniProtKB/Swiss-Prot:P04990" /translation="MWKGLIHQYKEFLPVTDQTPALTLHEGNTPLIHLPKLSEQLGIE LHVKTEGVNPTGSFKDRGMVMAVAKAKEEGNDTIMCASTGNTSAAAAAYAARANMKCI VIIPNGKIAFGKLAQAVMYGAEIIAIDGNFDDALKIVRSICEKSPIALVNSVNPYRIE GQKTAAFEVCEQLGEAPDVLAIPVGNAGNITAYWKGFKEYHEKNGTGLPKMRGFEAEG AAAIVRNEVIENPETIATAIRIGNPASWDKAVKAAEESNGKIDEVTDDEILHAYQLIA RVEGVFAEPGSCASIAGVLKQVKSGEIPKGSKVVAVLTGNGLKDPNTAVDISEIKPVT LPTDEDSILEYVKGAARV*" /label="thrC CDS" gene complement(2964884..2965942) /gene="thrC" /locus_tag="BSU_32250" /old_locus_tag="BSU32250" /label="thrC gene" CDS complement(2965942..2967243) /gene="hom" /locus_tag="BSU_32260" /old_locus_tag="BSU32260" /EC_number="1.1.1.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:3139660, 27299409" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3139660, 27299409; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="homoserine dehydrogenase" /protein_id="NP_391106.1" /db_xref="EnsemblGenomes-Gn:BSU32260" /db_xref="EnsemblGenomes-Tr:CAB15216" /db_xref="GOA:P19582" /db_xref="InterPro:IPR001342" /db_xref="InterPro:IPR002912" /db_xref="InterPro:IPR005106" /db_xref="InterPro:IPR016204" /db_xref="InterPro:IPR019811" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10460" /db_xref="UniProtKB/Swiss-Prot:P19582" /translation="MKAIRVGLLGLGTVGSGVVKIIQDHQDKLMHQVGCPVTIKKVLV KDLEKKREVDLPKEVLTTEVYDVIDDPDVDVVIEVIGGVEQTKQYLVDALRSKKHVVT ANKDLMAVYGSELLAEAKENGCDIYFEASVAGGIPILRTLEEGLSSDRITKMMGIVNG TTNFILTKMIKEKSPYEEVLKEAQDLGFAEADPTSDVEGLDAARKMAILARLGFSMNV DLEDVKVKGISQITDEDISFSKRLGYTMKLIGIAQRDGSKIEVSVQPTLLPDHHPLSA VHNEFNAVYVYGEAVGETMFYGPGAGSMPTATSVVSDLVAVMKNMRLGVTGNSFVGPQ YEKNMKSPSDIYAQQFLRIHVKDEVGSFSKITSVFSERGVSFEKILQLPIKGHDELAE IVIVTHHTSEADFSDILQNLNDLEVVQEVKSTYRVEGNGWS*" /label="hom CDS" gene complement(2965942..2967243) /gene="hom" /locus_tag="BSU_32260" /old_locus_tag="BSU32260" /label="hom gene" promotor_-35 2967128..2967137 /Source="Nicolas_upshift_promotors" /id="U2529" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1386 /SigmaFactorBS="tctctaaatcttttacaagcactttttttATCGTAACCGgac agccgacctgaTGCATAAGCTTATCCTGATGgtcttgaataattttaacgacaccgct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2967152..2967171 /Source="Nicolas_upshift_promotors" /id="U2529" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1386 /SigmaFactorBS="tctctaaatcttttacaagcactttttttATCGTAACCGgac agccgacctgaTGCATAAGCTTATCCTGATGgtcttgaataattttaacgacaccgct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2967159 /Source="Nicolas_upshifts" /id="U2529" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1386 /SigmaFactorBS="tctctaaatcttttacaagcactttttttATCGTAACCGgac agccgacctgaTGCATAAGCTTATCCTGATGgtcttgaataattttaacgacaccgct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2967244..2967325) /Source="Nicolas_S_feature" /locus_tag="new_3316130_3316211_c" /HighExp="T3.0H, T2.30H, T3.30H, S2, C90, T4.0H, BMM, SMM, MG 120, UNK1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1245" promotor_-10 complement(2967310..2967329) /Source="Nicolas_upshift_promotors" /id="U2530" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=3043 /SigmaFactorBS="agcgtttacattcgcaaaattcagcctaatgatgTCTTGTCA aaacaggagcgggcTTATATAATGTTTGTAACTTatatgtctgtgttgagttaacaat t" /listShort="S1245, hom, thrC, thrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2967325) /Source="Nicolas_upshifts" /id="U2530" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=3043 /SigmaFactorBS="agcgtttacattcgcaaaattcagcctaatgatgTCTTGTCA aaacaggagcgggcTTATATAATGTTTGTAACTTatatgtctgtgttgagttaacaat t" /listShort="S1245, hom, thrC, thrB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2967327..2967443) /Source="Nicolas_S_feature" /locus_tag="new_3316213_3316329_c" /HighExp="S5, S3, S4, S7, S6, S8, BT, B36, LoTm, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1246" promotor_-35 complement(2967344..2967351) /Source="Nicolas_upshift_promotors" /id="U2530" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.986013986013986" /psig=1 /xcortree=3043 /SigmaFactorBS="agcgtttacattcgcaaaattcagcctaatgatgTCTTGTCA aaacaggagcgggcTTATATAATGTTTGTAACTTatatgtctgtgttgagttaacaat t" /listShort="S1245, hom, thrC, thrB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2967444..2968463) /gene="cotNH" /locus_tag="BSU_32270" /old_locus_tag="BSU32270" /function="16.3: Control" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15231775, 22882546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15231775, 22882546; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat-associated protein" /protein_id="NP_391107.1" /db_xref="EnsemblGenomes-Gn:BSU32270" /db_xref="EnsemblGenomes-Tr:CAB15217" /db_xref="GOA:O32123" /db_xref="InterPro:IPR011009" /db_xref="InterPro:IPR014254" /db_xref="SubtiList:BG14044" /db_xref="UniProtKB/Swiss-Prot:O32123" /translation="MVKGTIKEKYGIHIRQLSMYQHTYQCFQTPNSYFLIVPVSQFSE TELAELYYMSQYLQEQSDPYVSVFIFTKEGELTFEHEGKTYALLKAAPPYSNRAFSIG AELAEFHRKGRGYPYEVKAAGRIGQWKDLWGKRIDQLEAFWQRKVQTPPHEPFDKKMI ESFPYYLGLSENAIQYLVDTELDDKPQAADSGTICHQRMERHTWSPESLIRIPADWVF DHASRDLAEYMRHTFLHHRQDFNQQGFLFLQEYEQVTPLSSFSKRLLYSRLLFPLHYF EIVESYYMSSESEKHYFEEQLDFILNDCGRYEQFLNTAQEFMNMRAQKLFVPRVSWLG KGSSR*" /label="cotNH CDS" gene complement(2967444..2968463) /gene="cotNH" /locus_tag="BSU_32270" /old_locus_tag="BSU32270" /label="cotNH gene" promotor_-35 2968271..2968276 /Source="Nicolas_upshift_promotors" /id="U2531" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.813186813186813" /psig="0.813186813186813" /xcortree=1020 /SigmaFactorBS="cagttcaccttcttttgtaaagataaaaaccgaaaCGTATGg gtcactttgttcttGTAAATACTGACTCATGTAataaagctccgccagctctgtttct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2968292..2968310 /Source="Nicolas_upshift_promotors" /id="U2531" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.813186813186813" /psig="0.813186813186813" /xcortree=1020 /SigmaFactorBS="cagttcaccttcttttgtaaagataaaaaccgaaaCGTATGg gtcactttgttcttGTAAATACTGACTCATGTAataaagctccgccagctctgtttct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2968296 /Source="Nicolas_upshifts" /id="U2531" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.813186813186813" /psig="0.813186813186813" /xcortree=1020 /SigmaFactorBS="cagttcaccttcttttgtaaagataaaaaccgaaaCGTATGg gtcactttgttcttGTAAATACTGACTCATGTAataaagctccgccagctctgtttct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2968486..2968504) /Source="Nicolas_upshift_promotors" /id="U2532" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1126 /SigmaFactorBS="ttgcgccttcttcggattaaaatatgtaTTCATAattccggc tgtgtatGACTACGATGTGATGAGCCctaattcaacaggcaggtgatcatggtgaaag g" /listShort="yutH, S1246, S1245, hom, thrC, thrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2968493) /Source="Nicolas_upshifts" /id="U2532" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1126 /SigmaFactorBS="ttgcgccttcttcggattaaaatatgtaTTCATAattccggc tgtgtatGACTACGATGTGATGAGCCctaattcaacaggcaggtgatcatggtgaaag g" /listShort="yutH, S1246, S1245, hom, thrC, thrB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2968502..2968507 /Source="Nicolas_upshift_promotors" /id="U2533" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1124 /SigmaFactorBS="tgatcacctgcctgttgaattagggctcatcacatcgtaGTC ATAcacagccggaattatGAATACATATTTTAATCCGaagaaggcgcaagaaaaagtc g" /listShort="S1247, yutG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(2968520..2968525) /Source="Nicolas_upshift_promotors" /id="U2532" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1126 /SigmaFactorBS="ttgcgccttcttcggattaaaatatgtaTTCATAattccggc tgtgtatGACTACGATGTGATGAGCCctaattcaacaggcaggtgatcatggtgaaag g" /listShort="yutH, S1246, S1245, hom, thrC, thrB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 2968523..2968587 /Source="Nicolas_S_feature" /locus_tag="new_3317409_3317473" /HighExp="S4, S5, S3, S6, S7, B36, S8, LoTm, Pyr, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1247" promotor_-10 2968523..2968541 /Source="Nicolas_upshift_promotors" /id="U2533" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1124 /SigmaFactorBS="tgatcacctgcctgttgaattagggctcatcacatcgtaGTC ATAcacagccggaattatGAATACATATTTTAATCCGaagaaggcgcaagaaaaagtc g" /listShort="S1247, yutG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2968523 /Source="Nicolas_upshifts" /id="U2533" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1124 /SigmaFactorBS="tgatcacctgcctgttgaattagggctcatcacatcgtaGTC ATAcacagccggaattatGAATACATATTTTAATCCGaagaaggcgcaagaaaaagtc g" /listShort="S1247, yutG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2968560..2968569 /Source="Nicolas_upshift_promotors" /id="U2534" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.86013986013986" /psig="0.86013986013986" /xcortree=1330 /SigmaFactorBS="atattttaatccgaagaaggcgcaagaaaaaGTCGTAAACTt ctcaagcatttTGTATAAACTAGTAAAAAAGattgggtgaagctgatgtcagaaaacg a" /listShort="yutG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2968582..2968601 /Source="Nicolas_upshift_promotors" /id="U2534" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.86013986013986" /psig="0.86013986013986" /xcortree=1330 /SigmaFactorBS="atattttaatccgaagaaggcgcaagaaaaaGTCGTAAACTt ctcaagcatttTGTATAAACTAGTAAAAAAGattgggtgaagctgatgtcagaaaacg a" /listShort="yutG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2968589 /Source="Nicolas_upshifts" /id="U2534" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.86013986013986" /psig="0.86013986013986" /xcortree=1330 /SigmaFactorBS="atattttaatccgaagaaggcgcaagaaaaaGTCGTAAACTt ctcaagcatttTGTATAAACTAGTAAAAAAGattgggtgaagctgatgtcagaaaacg a" /listShort="yutG" /GFF_Attribute="listLong" /label="upshifts" CDS 2968616..2969116 /gene="yutG" /locus_tag="BSU_32280" /old_locus_tag="BSU32280" /function="16.8: Protect" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22333191; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphatidylglycerophosphatase" /protein_id="NP_391108.1" /db_xref="EnsemblGenomes-Gn:BSU32280" /db_xref="EnsemblGenomes-Tr:CAB15218" /db_xref="GOA:O32124" /db_xref="InterPro:IPR007686" /db_xref="InterPro:IPR026038" /db_xref="InterPro:IPR036681" /db_xref="SubtiList:BG14043" /db_xref="UniProtKB/Swiss-Prot:O32124" /translation="MSENEQFSQMEAKARARMKERGVEVSDIAELVFFLQKKYHPDLT IDECTLNVNRVLAKREVQNAILTGIELDVLAEQKKLSEPLQTMLEIDESLYGVDEVLA FSIVNIYGSIGFTNYGYIDKEKPGILKRLNDKSTGECHTFLDDIVGAISAAASSRLAH RARHTE*" /label="yutG CDS" gene 2968616..2969116 /gene="yutG" /locus_tag="BSU_32280" /old_locus_tag="BSU32280" /label="yutG gene" CDS complement(2969143..2969913) /gene="nucF" /locus_tag="BSU_32290" /old_locus_tag="BSU32290" /EC_number="3.1.3.5" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15664928, 16766528, 27907199" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15664928, 16766528, 27907199; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5' nucleotidase, promiscuous" /protein_id="NP_391109.1" /db_xref="EnsemblGenomes-Gn:BSU32290" /db_xref="EnsemblGenomes-Tr:CAB15219" /db_xref="GOA:O32125" /db_xref="InterPro:IPR006354" /db_xref="InterPro:IPR006357" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="PDB:3PDW" /db_xref="SubtiList:BG14042" /db_xref="UniProtKB/Swiss-Prot:O32125" /translation="MKTYKGYLIDLDGTMYNGTEKIEEACEFVRTLKDRGVPYLFVTN NSSRTPKQVADKLVSFDIPATEEQVFTTSMATAQHIAQQKKDASVYVIGEEGIRQAIE ENGLTFGGENADFVVVGIDRSITYEKFAVGCLAIRNGARFISTNGDIAIPTERGLLPG NGSLTSVLTVSTGVQPVFIGKPESIIMEQAMRVLGTDVSETLMVGDNYATDIMAGINA GMDTLLVHTGVTKREHMTDDMEKPTHAIDSLTEWIPYI*" /label="nucF CDS" gene complement(2969143..2969913) /gene="nucF" /locus_tag="BSU_32290" /old_locus_tag="BSU32290" /label="nucF gene" downshifts complement(2969171) /Source="Nicolas_upshifts" /id="D1676" /incds=0 /nref=137 /ntot=243 /MaxReadThrough="2.15034" /MaxDrop="4.82801" /score="8.09889752" /energy="-15.6" /TU="NA" /idTUdmin="U2535" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2969942..2970376) /gene="yutE" /locus_tag="BSU_32300" /old_locus_tag="BSU32300" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 27907199" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391110.1" /db_xref="EnsemblGenomes-Gn:BSU32300" /db_xref="EnsemblGenomes-Tr:CAB15220" /db_xref="InterPro:IPR008201" /db_xref="PDB:1YLM" /db_xref="SubtiList:BG14041" /db_xref="UniProtKB/Swiss-Prot:O32126" /translation="MYFVDRSKIEKTLGFFEHQLALFDSQTDWQSEIGELALQRIGHL LIECILDTGNDMIDGFIMRDPGSYDDIMDILVDEKVVTEKEGDELKKLIAYRKTLVQQ YLLADSGELYRLIKAHQTALQDFPKRIRSYLETELGPVSAFK*" /label="yutE CDS" gene complement(2969942..2970376) /gene="yutE" /locus_tag="BSU_32300" /old_locus_tag="BSU32300" /label="yutE gene" CDS complement(2970400..2970675) /gene="yutD" /locus_tag="BSU_32310" /old_locus_tag="BSU32310" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12770717, 27907199" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391111.2" /db_xref="EnsemblGenomes-Gn:BSU32310" /db_xref="EnsemblGenomes-Tr:CAB15221" /db_xref="InterPro:IPR009370" /db_xref="PDB:2KL5" /db_xref="SubtiList:BG14040" /db_xref="UniProtKB/Swiss-Prot:O32127" /translation="MILIQNAEFELVHNFKDGFNEEAFKARYSDILNKYDYIVGDWGY GQLRLKGFFDDQNQKATFETKISTLDEYIYEYCNFGCAYFVLKRIRK*" /label="yutD CDS" gene complement(2970400..2970675) /gene="yutD" /locus_tag="BSU_32310" /old_locus_tag="BSU32310" /label="yutD gene" promotor_-10 complement(2970695..2970714) /Source="Nicolas_upshift_promotors" /id="U2535" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.65034965034965" /psig=1 /xcortree=2678 /SigmaFactorBS="cctcctcatgtgtagggtagccaaatcgcatgatttattctt tagCAATTGATggggacggggcaaTGAATTATGATAGGAATGAGtgaaaaaagaggtg a" /listShort="yutD, yutE, yutF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2970720) /Source="Nicolas_upshifts" /id="U2535" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.65034965034965" /psig=1 /xcortree=2678 /SigmaFactorBS="cctcctcatgtgtagggtagccaaatcgcatgatttattctt tagCAATTGATggggacggggcaaTGAATTATGATAGGAATGAGtgaaaaaagaggtg a" /listShort="yutD, yutE, yutF" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(2970722..2971414) /Source="Nicolas_S_feature" /locus_tag="new_3319608_3320300_c" /HighExp="G135, G150, G180, H2O2, LBGtran, LBGexp, Paraq, dia15, C90, HiOs" /AntisenseName="yutC" /AntisenseCor="-0.57886192731570996" /AntisenseRegPval="-24.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1248" promotor_-35 complement(2970728..2970735) /Source="Nicolas_upshift_promotors" /id="U2535" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.65034965034965" /psig=1 /xcortree=2678 /SigmaFactorBS="cctcctcatgtgtagggtagccaaatcgcatgatttattctt tagCAATTGATggggacggggcaaTGAATTATGATAGGAATGAGtgaaaaaagaggtg a" /listShort="yutD, yutE, yutF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 2970738..2970744 /Source="Nicolas_upshift_promotors" /id="U2536" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.711288711288711" /psig="0.711288711288711" /xcortree=851 /SigmaFactorBS="ataattcattgccccgtccccatcaattgctAAAGAATaaat catgcgatttGGCTACCCTACAcatgaggagggattgataaatgaaacgaaccgctgt c" /listShort="yutC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2970759..2970770 /Source="Nicolas_upshift_promotors" /id="U2536" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.711288711288711" /psig="0.711288711288711" /xcortree=851 /SigmaFactorBS="ataattcattgccccgtccccatcaattgctAAAGAATaaat catgcgatttGGCTACCCTACAcatgaggagggattgataaatgaaacgaaccgctgt c" /listShort="yutC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2970767 /Source="Nicolas_upshifts" /id="U2536" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.711288711288711" /psig="0.711288711288711" /xcortree=851 /SigmaFactorBS="ataattcattgccccgtccccatcaattgctAAAGAATaaat catgcgatttGGCTACCCTACAcatgaggagggattgataaatgaaacgaaccgctgt c" /listShort="yutC" /GFF_Attribute="listLong" /label="upshifts" CDS 2970790..2971422 /gene="yutC" /locus_tag="BSU_32320" /old_locus_tag="BSU32320" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative sporulation-related lipoprotein" /protein_id="NP_391112.1" /db_xref="EnsemblGenomes-Gn:BSU32320" /db_xref="EnsemblGenomes-Tr:CAB15222" /db_xref="GOA:O32128" /db_xref="InterPro:IPR019076" /db_xref="SubtiList:BG14039" /db_xref="UniProtKB/Swiss-Prot:O32128" /translation="MKRTAVSLCLLTGLLSGCGGAGLDNAQNVRNQTQNQTKPIHVSD RNEAFNRHNENEQFGYVRYQKEQFDGEQQKTPVMNREETAHMISSLTVQLPHIQDAAT LVTDREALVVYKTDSKNRELTADQVKKTAASVIPRYYHVYISDNPNHMQSVENYSNLG SGSRDIREIMSGTIQEMKTSPQGSPVSENENANGETRQDMKIDRNDKNAR*" /label="yutC CDS" gene 2970790..2971422 /gene="yutC" /locus_tag="BSU_32320" /old_locus_tag="BSU32320" /label="yutC gene" downshifts 2971383 /Source="Nicolas_upshifts" /id="D1677" /incds=0 /nref=9 /ntot=30 /MaxReadThrough="1.84979" /MaxDrop="3.55825" /score="-2.38634221" /energy="-9.6" /TU="NA" /idTUdmin="U2536" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2971438..2972334) /gene="lipA" /locus_tag="BSU_32330" /old_locus_tag="BSU32330" /EC_number="2.8.1.8" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15362861, 16835858, 19028902, 19820084, 25341020; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="lipoyl synthase (lipoic acid synthetase)" /protein_id="NP_391113.2" /db_xref="EnsemblGenomes-Gn:BSU32330" /db_xref="EnsemblGenomes-Tr:CAB15223" /db_xref="GOA:O32129" /db_xref="InterPro:IPR003698" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR031691" /db_xref="SubtiList:BG14038" /db_xref="UniProtKB/Swiss-Prot:O32129" /translation="MAKKDEHLRKPEWLKIKLNTNENYTGLKKLMRENNLHTVCEEAK CPNIHECWAVRRTATFMILGSVCTRACRFCAVKTGLPTELDLQEPERVADSVALMNLK HAVITAVARDDQKDGGAGIFAETVRAIRRKSPFTTIEVLPSDMGGNYDNLKTLMDTRP DILNHNIETVRRLTPRVRARATYDRSLEFLRRAKEMQPDIPTKSSIMIGLGETKEEII EVMDDLLANNVDIMAIGQYLQPTKKHLKVQKYYHPDEFAELKEIAMQKGFSHCEAGPL VRSSYHADEQVNEASKKRQAQA*" /label="lipA CDS" gene complement(2971438..2972334) /gene="lipA" /locus_tag="BSU_32330" /old_locus_tag="BSU32330" /label="lipA gene" downshifts complement(2971459) /Source="Nicolas_upshifts" /id="D1678" /incds=0 /nref=186 /ntot=261 /MaxReadThrough="3.83236" /MaxDrop="5.33309" /score="14.803008" /energy="-9.6" /TU="U2537" /idTUdmin="U2537" /TUdmin="-726" /isTUend="FALSE" /label="downshifts" S_feature complement(2972335..2972469) /Source="Nicolas_S_feature" /locus_tag="new_3321221_3321355_c" /HighExp="HiOs, LBGtran, dia15, dia5, C90, Diami, dia0, LBGexp, Heat, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1249" promotor_-10 complement(2972456..2972475) /Source="Nicolas_upshift_promotors" /id="U2537" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.651348651348651" /psig=1 /xcortree=2669 /SigmaFactorBS="gcaacccggcttaaaaatgtcagtaatcatcttcCCTTGtcg agaaatttttccTATGTTAAAGTGTCTAAAGAaaagactttctttagttagaaaaaca t" /listShort="S1249, lipA, S1248" /listLong="yutD, yutE, yutF" /label="promotor_-10" upshifts complement(2972469) /Source="Nicolas_upshifts" /id="U2537" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.651348651348651" /psig=1 /xcortree=2669 /SigmaFactorBS="gcaacccggcttaaaaatgtcagtaatcatcttcCCTTGtcg agaaatttttccTATGTTAAAGTGTCTAAAGAaaagactttctttagttagaaaaaca t" /listShort="S1249, lipA, S1248" /listLong="yutD, yutE, yutF" /label="upshifts" promotor_-35 complement(2972491..2972495) /Source="Nicolas_upshift_promotors" /id="U2537" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.651348651348651" /psig=1 /xcortree=2669 /SigmaFactorBS="gcaacccggcttaaaaatgtcagtaatcatcttcCCTTGtcg agaaatttttccTATGTTAAAGTGTCTAAAGAaaagactttctttagttagaaaaaca t" /listShort="S1249, lipA, S1248" /listLong="yutD, yutE, yutF" /label="promotor_-35" promotor_-35 2972509..2972515 /Source="Nicolas_upshift_promotors" /id="U2538" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=866 /SigmaFactorBS="aatttctcgacaagggaagatgattactGACATTTttaagcc gggttgCCGCAAACTATGtgtattcaatatgaaaggagattattttgtgaaagttttg t" /listShort="lytH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2972529..2972540 /Source="Nicolas_upshift_promotors" /id="U2538" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=866 /SigmaFactorBS="aatttctcgacaagggaagatgattactGACATTTttaagcc gggttgCCGCAAACTATGtgtattcaatatgaaaggagattattttgtgaaagttttg t" /listShort="lytH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2972541 /Source="Nicolas_upshifts" /id="U2538" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=866 /SigmaFactorBS="aatttctcgacaagggaagatgattactGACATTTttaagcc gggttgCCGCAAACTATGtgtattcaatatgaaaggagattattttgtgaaagttttg t" /listShort="lytH" /GFF_Attribute="listLong" /label="upshifts" CDS 2972569..2973549 /gene="lytH" /locus_tag="BSU_32340" /old_locus_tag="BSU32340" /EC_number="3.4.-.-" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12813075; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="sporulation-specific L-Ala-D-Glu endopeptidase" /protein_id="NP_391114.2" /db_xref="EnsemblGenomes-Gn:BSU32340" /db_xref="EnsemblGenomes-Tr:CAB15224" /db_xref="GOA:O32130" /db_xref="InterPro:IPR011055" /db_xref="InterPro:IPR016047" /db_xref="SubtiList:BG13975" /db_xref="UniProtKB/Swiss-Prot:O32130" /translation="MKVLLSALLLLLFAFEPSASGKKLSDPVLSKRMELYHKIEAVTQ IPWYALAAVDQYEENVRSNRKDLPEKAGIISIYIPDDIWSGPENPNPKDDAPLSIKVF DGIGMDGDGDGKAEVSNDEDILYTFSQYLLSYGTDEDNIRIGLWNYYRRDQTVGIISE FMKLFKAYGHIDLGEHAFPLPIRTDYSYRSTWGDARGFGGRRIHEGTDIFAHYGLPVK STCYGVVEMKGWNRFGGWRIGIRDINNTYHYFAHLNGFAKGIKTGQIVEPGQVIGSVG SSGYGPPGTAGKFPPHLHYGMYKDNGRTEWSFDPYPHLRAWERYEYQKKK*" /label="lytH CDS" gene 2972569..2973549 /gene="lytH" /locus_tag="BSU_32340" /old_locus_tag="BSU32340" /label="lytH gene" upshifts complement(2972647) /Source="Nicolas_upshifts" /id="U2539" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.832167832167832" /psig="0.873126873126873" /xcortree=2473 /SigmaFactorBS="aagggatCTGCgtcacagcttcgatttTATGATATAATTCCA TCCGTttcgacagcactggatctgaaagtttttttccagacgcagaaggctcaaatgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(2972661..2972680) /Source="Nicolas_upshift_promotors" /id="U2539" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.832167832167832" /psig="0.873126873126873" /xcortree=2473 /SigmaFactorBS="aagggatCTGCgtcacagcttcgatttTATGATATAATTCCA TCCGTttcgacagcactggatctgaaagtttttttccagacgcagaaggctcaaatgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(2972697..2972700) /Source="Nicolas_upshift_promotors" /id="U2539" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.832167832167832" /psig="0.873126873126873" /xcortree=2473 /SigmaFactorBS="aagggatCTGCgtcacagcttcgatttTATGATATAATTCCA TCCGTttcgacagcactggatctgaaagtttttttccagacgcagaaggctcaaatgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 2973541 /Source="Nicolas_upshifts" /id="D1679" /incds=0 /nref=35 /ntot=74 /MaxReadThrough="0.613989999999999" /MaxDrop="8.59238" /score="-3.31011906" /energy="-20" /TU="NA" /idTUdmin="U2538" /TUdmin=2 /isTUend="TRUE" /label="downshifts" CDS complement(2973577..2974341) /gene="fisB" /locus_tag="BSU_32350" /old_locus_tag="BSU32350" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:12662922, 23388828" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12662922, 23388828; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="protein required for membrane fission during spore formation" /protein_id="NP_391115.1" /db_xref="EnsemblGenomes-Gn:BSU32350" /db_xref="EnsemblGenomes-Tr:CAB15225" /db_xref="GOA:O32131" /db_xref="InterPro:IPR014197" /db_xref="SubtiList:BG13976" /db_xref="UniProtKB/Swiss-Prot:O32131" /translation="MPRYRGPFRKRGPLPFRYVMLLSVVFFILSTTVSLWMINGSIKP VLMDIGEMETKRIATEVIQDSIEDYMSDSENMKDMFQMNSDENGNLTTIDFNTQVVNS VKTKVTKQLQAHLKEMETHTGHSGASENIMINIPLGQVTGNSLLGNLGPKIPVRFNLI GDAFTDVKTKIKPYGINNALIDISIFVEIKVKVIIPFASKTAVVTNNVPVSIKAVQGE VPQFYNGSGGSGVTPSVQLPSSKENGADSKKEKSSK*" /label="fisB CDS" gene complement(2973577..2974341) /gene="fisB" /locus_tag="BSU_32350" /old_locus_tag="BSU32350" /label="fisB gene" downshifts complement(2973593) /Source="Nicolas_upshifts" /id="D1680" /incds=0 /nref=74 /ntot=226 /MaxReadThrough="3.15258" /MaxDrop="6.53891" /score="23.5286262" /energy="-12.4" /TU="NA" /idTUdmin="U2540" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(2974355..2974373) /Source="Nicolas_upshift_promotors" /id="U2540" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1007 /SigmaFactorBS="gatgaaataaaataaattggccccggctaTTACTAtgtcccc tcttacaaGCATACATTGTGATATGTAaggggggattttcttgccaagatatcgcggc c" /listShort="yunB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2974363) /Source="Nicolas_upshifts" /id="U2540" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1007 /SigmaFactorBS="gatgaaataaaataaattggccccggctaTTACTAtgtcccc tcttacaaGCATACATTGTGATATGTAaggggggattttcttgccaagatatcgcggc c" /listShort="yunB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2974389..2974394) /Source="Nicolas_upshift_promotors" /id="U2540" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1007 /SigmaFactorBS="gatgaaataaaataaattggccccggctaTTACTAtgtcccc tcttacaaGCATACATTGTGATATGTAaggggggattttcttgccaagatatcgcggc c" /listShort="yunB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2974414..2974719) /gene="yunC" /locus_tag="BSU_32360" /old_locus_tag="BSU32360" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391116.1" /db_xref="EnsemblGenomes-Gn:BSU32360" /db_xref="EnsemblGenomes-Tr:CAB15226" /db_xref="InterPro:IPR014931" /db_xref="InterPro:IPR036493" /db_xref="SubtiList:BG13977" /db_xref="UniProtKB/Swiss-Prot:O32132" /translation="MVNLTPIMIEGQPFTAVTVKLPKTNFMAVANDHGYIMCGALDVA LLNEKLKERGIVAGRAVGVRTIDQLLDAPLESVTYAAEDLGIKVGMSGREALLKMMK* " /label="yunC CDS" gene complement(2974414..2974719) /gene="yunC" /locus_tag="BSU_32360" /old_locus_tag="BSU32360" /label="yunC gene" downshifts complement(2974422) /Source="Nicolas_upshifts" /id="D1681" /incds=0 /nref=3 /ntot=128 /MaxReadThrough="5.18714" /MaxDrop="3.9347" /score="-2.65376612" /energy="-18.9" /TU="U2541,U2543,U2544" /idTUdmin="U2540" /TUdmin="-829" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(2974733..2974752) /Source="Nicolas_upshift_promotors" /id="U2541" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1347 /SigmaFactorBS="cgggatctgcttgcttggaagcttgcacaataaggcagtcag CCCACAACAagctgtgcccttcATCATAAAGTGATGAATGAAgggagtggttgacgtg g" /listShort="yunC, yunB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2974756) /Source="Nicolas_upshifts" /id="U2541" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1347 /SigmaFactorBS="cgggatctgcttgcttggaagcttgcacaataaggcagtcag CCCACAACAagctgtgcccttcATCATAAAGTGATGAATGAAgggagtggttgacgtg g" /listShort="yunC, yunB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2974766..2974774) /Source="Nicolas_upshift_promotors" /id="U2541" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=1347 /SigmaFactorBS="cgggatctgcttgcttggaagcttgcacaataaggcagtcag CCCACAACAagctgtgcccttcATCATAAAGTGATGAATGAAgggagtggttgacgtg g" /listShort="yunC, yunB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2974784..2976172) /gene="yunD" /locus_tag="BSU_32370" /old_locus_tag="BSU32370" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative nuclease/nucleotidase/phosphoesterase" /protein_id="NP_391117.1" /db_xref="EnsemblGenomes-Gn:BSU32370" /db_xref="EnsemblGenomes-Tr:CAB15227" /db_xref="GOA:O32133" /db_xref="InterPro:IPR006179" /db_xref="InterPro:IPR008334" /db_xref="InterPro:IPR011240" /db_xref="InterPro:IPR029052" /db_xref="InterPro:IPR036907" /db_xref="SubtiList:BG13978" /db_xref="UniProtKB/Swiss-Prot:O32133" /translation="MKEKLRLYHTNDLHSHFENWPKIVDYIEQKRKEHQSDGEETLVF DIGDHLDRFQFVTEATFGKANVDLLNRLHIDGAAIGNNEGITLPHEELAALYDHAEFP VIVSNLFDKNGNRPSWAVPYHIKSLKNGMSIAFLGVTVPYYPVYDKLGWTVTDALESI KETILEVKGQADIIVLLSHLGILDDQAVAEAVPEIDVILESHTHHLLEDGQVVNGVLL ASAEKYGHYVGCVEITVDSVQRSINSKTASVQNMAEWTGESAETKAFLNEKEREAEEK LSDAVAELAQDAEVKWFEESELPLLLAYALKEWCETDISMVNSGVILGPLKAGPVTKL DLHRICPHPINPVAVRLTGEELKETIVHAASEQMEQLRIKGLGFRGEVMGKMVYAGVE VETKRLDDGITHVTRITLNGEDIEKHKQYSVAVLDMFTLGKLFPLIRDAAEKEYFMPE FLRDLLAWKLAQ*" /label="yunD CDS" gene complement(2974784..2976172) /gene="yunD" /locus_tag="BSU_32370" /old_locus_tag="BSU32370" /label="yunD gene" CDS complement(2976192..2977013) /gene="yunE" /locus_tag="BSU_32380" /old_locus_tag="BSU32380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_391118.1" /db_xref="EnsemblGenomes-Gn:BSU32380" /db_xref="EnsemblGenomes-Tr:CAB15228" /db_xref="GOA:O32134" /db_xref="InterPro:IPR002781" /db_xref="SubtiList:BG13979" /db_xref="UniProtKB/Swiss-Prot:O32134" /translation="MSFVILVVLGLIAGTVGSLIGLGGGIVIVPSLMFLSTVTQLFQD VTPQVAIGTSLLVIIFTGLSSTLAYIKYKTVDYKSGLIFFIGSGPGSMIGAYVSKLFN SNSFSVWFGIFMILISLSLMLKAKARPINKAHKGIIRTFQDDAGEPYTYSYQASVGIA IAFVVGFLGGLFGIGGGSLMVPAMMLLFLFPPKVAVATSMFIIFLSSMTGSVSHMISG HVNWLYALALVPGAWFGGKLGAAINRKMQTKTIVMIMRIVLILIGCQLIYEGIFS*" /label="yunE CDS" gene complement(2976192..2977013) /gene="yunE" /locus_tag="BSU_32380" /old_locus_tag="BSU32380" /label="yunE gene" CDS complement(2977031..2977879) /gene="yunF" /locus_tag="BSU_32390" /old_locus_tag="BSU32390" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391119.2" /db_xref="EnsemblGenomes-Gn:BSU32390" /db_xref="EnsemblGenomes-Tr:CAB15229" /db_xref="InterPro:IPR002763" /db_xref="InterPro:IPR036520" /db_xref="SubtiList:BG13980" /db_xref="UniProtKB/Swiss-Prot:O32135" /translation="MIYIGLTGWGDHDSIYPPKTASQKKLQAYSSHFPIVELDASFYA IQPARNNEKWVKETPETFQFIVKAYQGMTGHQRGEIPFDSKEEMFDAFKVSLTPYLHS NKLAMVLFQFPPWFDCKKENVAYLRWCKHQMGDIPCALEFRNRSWFSPPFYEQTLSFM KAEGWIHSVCDEPQIGEGSVPTVLRATDENKTLVRFHGRNKQGWMKPDGGKNWREVRY LYRYNQQELEDWKKHLNELQQQCKDVFVLFNNNSGGDAADNGKQMLELLDIEYSGLAP RQLDLF*" /label="yunF CDS" gene complement(2977031..2977879) /gene="yunF" /locus_tag="BSU_32390" /old_locus_tag="BSU32390" /label="yunF gene" promotor_-35 2977398..2977403 /Source="Nicolas_upshift_promotors" /id="U2542" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1206 /SigmaFactorBS="gacactgtgaatccagccttccgctTTCATAaatgaaagcgt ctgcTCATAAAATGGCGGCGAGAaccaggaacggtttctgaattcaagcgcgcaagga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2977419..2977437 /Source="Nicolas_upshift_promotors" /id="U2542" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1206 /SigmaFactorBS="gacactgtgaatccagccttccgctTTCATAaatgaaagcgt ctgcTCATAAAATGGCGGCGAGAaccaggaacggtttctgaattcaagcgcgcaagga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2977433 /Source="Nicolas_upshifts" /id="U2542" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=1206 /SigmaFactorBS="gacactgtgaatccagccttccgctTTCATAaatgaaagcgt ctgcTCATAAAATGGCGGCGAGAaccaggaacggtttctgaattcaagcgcgcaagga a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(2977890..2977909) /Source="Nicolas_upshift_promotors" /id="U2543" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.915084915084915" /psig=1 /xcortree=1989 /SigmaFactorBS="gcgtgaggcattttcccgccatatgaacagcatttccgagga aacctgaaaacacgTGTGATAAACTGGAAGAGAGgtgaatgagtgtgatttatatcgg a" /listShort="yunF, yunE, yunD, yunC, yunB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2977905) /Source="Nicolas_upshifts" /id="U2543" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.915084915084915" /psig=1 /xcortree=1989 /SigmaFactorBS="gcgtgaggcattttcccgccatatgaacagcatttccgagga aacctgaaaacacgTGTGATAAACTGGAAGAGAGgtgaatgagtgtgatttatatcgg a" /listShort="yunF, yunE, yunD, yunC, yunB" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2977917..2978264) /gene="yunG" /locus_tag="BSU_32400" /old_locus_tag="BSU32400" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391120.1" /db_xref="EnsemblGenomes-Gn:BSU32400" /db_xref="EnsemblGenomes-Tr:CAB15230" /db_xref="SubtiList:BG13981" /db_xref="UniProtKB/Swiss-Prot:O32136" /translation="MEHVKYILKQSWSRHSSSKWTEECPSCGQCGVTALVIQDHFGGT IFKTRVDESWHFYNSINGVVYDFTSEQFQAPIEYQHIPSSREEAFLDTNEEQYQHLRE AFSRHMNSISEET*" /label="yunG CDS" gene complement(2977917..2978264) /gene="yunG" /locus_tag="BSU_32400" /old_locus_tag="BSU32400" /label="yunG gene" promotor_-10 complement(2978277..2978296) /Source="Nicolas_upshift_promotors" /id="U2544" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.594405594405594" /psig="0.95904095904096" /xcortree=2362 /SigmaFactorBS="ggcggattttaccgccgggttttttgatttcctccgttctAG TTTTTaaaatctcatcaaCGTGGTATCTTTTTTTAAAGgaggcggaggcaatggagca t" /listShort="yunG, yunF, yunE, yunD, yunC, yunB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2978296) /Source="Nicolas_upshifts" /id="U2544" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.594405594405594" /psig="0.95904095904096" /xcortree=2362 /SigmaFactorBS="ggcggattttaccgccgggttttttgatttcctccgttctAG TTTTTaaaatctcatcaaCGTGGTATCTTTTTTTAAAGgaggcggaggcaatggagca t" /listShort="yunG, yunF, yunE, yunD, yunC, yunB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2978310..2978316) /Source="Nicolas_upshift_promotors" /id="U2544" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.594405594405594" /psig="0.95904095904096" /xcortree=2362 /SigmaFactorBS="ggcggattttaccgccgggttttttgatttcctccgttctAG TTTTTaaaatctcatcaaCGTGGTATCTTTTTTTAAAGgaggcggaggcaatggagca t" /listShort="yunG, yunF, yunE, yunD, yunC, yunB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2978361..2979701) /gene="pucH" /locus_tag="BSU_32410" /old_locus_tag="BSU32410" /EC_number="3.5.2.5" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11344136, 12029039" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344136, 12029039; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="allantoinase" /protein_id="NP_391121.1" /db_xref="EnsemblGenomes-Gn:BSU32410" /db_xref="EnsemblGenomes-Tr:CAB15231" /db_xref="GOA:O32137" /db_xref="InterPro:IPR006680" /db_xref="InterPro:IPR011059" /db_xref="InterPro:IPR017593" /db_xref="InterPro:IPR032466" /db_xref="SubtiList:BG13982" /db_xref="UniProtKB/Swiss-Prot:O32137" /translation="MAYDMVIKGAKAVTPDGVIEADIVVQNGVIAEIGSDIEASGTEI IQADGKYVFPGVIDCHVHFNEPGREDWEGFETGSQMMAAGGCTTYFDMPLNCIPSTVT AEHLLAKAELGRQKSAVDFALWGGLVPGHIEDIRPMAEAGAIGFKAFLSKSGTDEFRS VDERTLLKGMAEIAAAGKILALHAESDAITSYLQMVLANKGKVDADAYAASRPEEAEV EAVYRTIQYAKVTGCPVHFVHISTAKAVRLIREAKQEGLDVSVETCPHYVLFSHDDLR QRGSVAKCAPPLRSRQSKETLIETLIAGDIDMVSSDHSPCRPSLKREDNMFLSWGGIS GGQFTLLGMLELALEHQIPFETIAEWTAAAPAKRFGLQKKGRLEAGCDADFVLVSMEP YTVTRESMFAKHKKSIYEGHTFPCSISATYSKGRCVYNDGEKVTEIDGALVVPS*" /label="pucH CDS" gene complement(2978361..2979701) /gene="pucH" /locus_tag="BSU_32410" /old_locus_tag="BSU32410" /label="pucH gene" downshifts complement(2978389) /Source="Nicolas_upshifts" /id="D1682" /incds=0 /nref=5 /ntot=28 /MaxReadThrough="0.88847" /MaxDrop="3.89144" /score="36.6188375" /energy="-15.4" /TU="NA" /idTUdmin="U2540" /TUdmin="-4796" /isTUend="FALSE" /label="downshifts" downshifts complement(2979445) /Source="Nicolas_upshifts" /id="D1683" /incds=1 /nref=1 /ntot=7 /MaxReadThrough="3.38784" /MaxDrop="3.36547" /score="36.6188375" /energy="-15.4" /TU="NA" /idTUdmin="U2540" /TUdmin="-5852" /isTUend="FALSE" /label="downshifts" promotor_-35 2979758..2979764 /Source="Nicolas_upshift_promotors" /id="U2545" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.432567432567433" /psig="0.96103896103896" /xcortree=318 /SigmaFactorBS="cgattttccatgtcagtttatgtaacacaaccAGTTCTAttt tcaacagtttACTGCTACTATGATCGTATTacatcagcaaaaccgctagaattcctat t" /listShort="S1250, pucR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2979778..2979797 /Source="Nicolas_upshift_promotors" /id="U2545" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.432567432567433" /psig="0.96103896103896" /xcortree=318 /SigmaFactorBS="cgattttccatgtcagtttatgtaacacaaccAGTTCTAttt tcaacagtttACTGCTACTATGATCGTATTacatcagcaaaaccgctagaattcctat t" /listShort="S1250, pucR" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(2979780..2979798) /Source="Nicolas_upshift_promotors" /id="U2546" /multdbtbs="SigA" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1026 /SigmaFactorBS="ataaaaacattggttaaggtgaataattttcaataggaATTC TAgcggttttgctgatgTAATACGATCATAGTAGCAgtaaactgttgaaaatagaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2979786 /Source="Nicolas_upshifts" /id="U2545" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.432567432567433" /psig="0.96103896103896" /xcortree=318 /SigmaFactorBS="cgattttccatgtcagtttatgtaacacaaccAGTTCTAttt tcaacagtttACTGCTACTATGATCGTATTacatcagcaaaaccgctagaattcctat t" /listShort="S1250, pucR" /GFF_Attribute="listLong" /label="upshifts" S_feature 2979787..2979875 /Source="Nicolas_S_feature" /locus_tag="new_3328673_3328761" /HighExp="BT, Cold, S0, LBGexp, S1, Lbtran, G150, T-1.40H, G180, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.961" /TUlongSig="NA" /TUlongPSig="NA" /label="S1250" upshifts complement(2979797) /Source="Nicolas_upshifts" /id="U2546" /multdbtbs="SigA" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1026 /SigmaFactorBS="ataaaaacattggttaaggtgaataattttcaataggaATTC TAgcggttttgctgatgTAATACGATCATAGTAGCAgtaaactgttgaaaatagaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2979814..2979819) /Source="Nicolas_upshift_promotors" /id="U2546" /multdbtbs="SigA" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1026 /SigmaFactorBS="ataaaaacattggttaaggtgaataattttcaataggaATTC TAgcggttttgctgatgTAATACGATCATAGTAGCAgtaaactgttgaaaatagaact g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 2979876..2981471 /gene="pucR" /locus_tag="BSU_32420" /old_locus_tag="BSU32420" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11344136, 12029039, 12374841" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344136, 12029039, 12374841; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of the purine degradation operon" /protein_id="NP_391122.1" /db_xref="EnsemblGenomes-Gn:BSU32420" /db_xref="EnsemblGenomes-Tr:CAB15232" /db_xref="GOA:O32138" /db_xref="InterPro:IPR012914" /db_xref="InterPro:IPR025736" /db_xref="InterPro:IPR028979" /db_xref="SubtiList:BG13983" /db_xref="UniProtKB/Swiss-Prot:O32138" /translation="MNILDVMKIPAFENANLIAGKAGGEREVQHVNMMDAPDIVDFLH KNELLVTTAYHLKDHPHQLSELIRQMAKRGCAGLGIKTKRYLEDIPKEIIELADSYAF PIIELPEHIRLGDIVNATLSHILDMRSNELQQAIYAHKKFTNHIMSGKGLQSLLKKVS DILQLPVLLLDQHAKMLSASHQISVETEKLKGTLNTVSGPFFTCFSTISDQKTYSVLP IYNHEKNCGYLLIPDMVQAGDKGLILTIEQAANVISFELLKENALKQFSRRARNEFFN NFIERTFSSDDEIKNRAKEFKLRWDQKYMCIAGKLDRNDESISFTENQLASDSVFEFL EGELSAFPFPPHFFMKGNVGIILIEATDSWSEMHASVISFLEQFQTQVSAQFKRTVSF GISNICQKLIDVPDAFTEASDALQSGHLSRSTAFIQVYHAKDVPELLRLLPVEDLKKF YNSTLQSLAEKQQEDQSLLHTLSVYLETHCQISETAKRLYVHRNTVIYRLEKCEELLG KSLKDPETTMRLRLALRMQRLIS*" /label="pucR CDS" gene 2979876..2981471 /gene="pucR" /locus_tag="BSU_32420" /old_locus_tag="BSU32420" /label="pucR gene" CDS 2981616..2982965 /gene="pucJ" /locus_tag="BSU_32430" /old_locus_tag="BSU32430" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11344136, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344136, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="uric acid permease" /protein_id="NP_391123.1" /db_xref="EnsemblGenomes-Gn:BSU32430" /db_xref="EnsemblGenomes-Tr:CAB15233" /db_xref="GOA:O32139" /db_xref="InterPro:IPR006042" /db_xref="InterPro:IPR006043" /db_xref="InterPro:IPR017588" /db_xref="SubtiList:BG13984" /db_xref="UniProtKB/Swiss-Prot:O32139" /translation="MKKRSFKVFTLSLQHVLAMYAGAILVPLLVGRALNVTTEQLSYL LAIDLLTCGVATLLQTLRGTYIGIGLPVMLGSSFVAVTPMIAIGSNYGIHAIYGSIIA AGVFIFLFARFFGKLTVLFPPVVTGTVVTLIGLSLVPTGVKNMAGGEKINGSANPEYG SLENLLLSVGVLVLILVLNRFLKGFARTLSVLIGIAAGTAAAAIMGKVSFSSVTEAPF FQIPKPFYFGAPAFEIGPILTMLIVGIVIIVESTGVFYAIGKICGRPLTDKDLVKGYR AEGIAILIGGLFNAFPYNTFAQNAGLLQLTKVKTRNIVVTAGCILVCLGLIPKIAALA SAVPAAVLGGATVVMFGMVIASGVKMLSTADLKNQYHLLTIACSIALGIGASTAPGIF AEFPAPIRILVSDGTITGSLTAIFLNLFFSLRDKKELTAQQTELPVLEHTLALEKEV* " /label="pucJ CDS" gene 2981616..2982965 /gene="pucJ" /locus_tag="BSU_32430" /old_locus_tag="BSU32430" /label="pucJ gene" CDS 2982971..2984263 /gene="pucK" /locus_tag="BSU_32440" /old_locus_tag="BSU32440" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11344136, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344136, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="uric acid permease subunit" /protein_id="NP_391124.1" /db_xref="EnsemblGenomes-Gn:BSU32440" /db_xref="EnsemblGenomes-Tr:CAB15234" /db_xref="GOA:O32140" /db_xref="InterPro:IPR006042" /db_xref="InterPro:IPR006043" /db_xref="InterPro:IPR017588" /db_xref="SubtiList:BG13985" /db_xref="UniProtKB/Swiss-Prot:O32140" /translation="MKEQHNALQLMMLGLQHMLAMYAGAILVPLIVGAAIGLNAGQLT YLIAIDLFMCGAATLLQLWRNRYFGIGLPVVLGCTFTAVGPMISIGSTYGVPAIYGAI IAAGLIVVLAAGFFGKLVRFFPPVVTGSVVMIIGISLIPTAMNNLAGGEGSKEFGSLD NVLLGFGVTAFILLLFYFFKGFIRSIAILLGLIAGTAAAYFMGKVDFSEVLEASWLHV PSLFYFGPPTFELPAVVTMLLVAIVSLVESTGVYFALADITNRRLSEKDLEKGYRAEG LAILLGGLFNAFPYTAFSQNVGIVQLSKMKSVNVIAITGIILVAIGLVPKAAALTTVI PTPVLGGAMIVMFGMVISYGIKMLSSVDLDSQGNLLIIASSVSLGLGATTVPALFSSL SGAASVLAGSGIVIGSLTAIALHAFFQTKQPNSADIKT*" /label="pucK CDS" gene 2982971..2984263 /gene="pucK" /locus_tag="BSU_32440" /old_locus_tag="BSU32440" /label="pucK gene" CDS 2984276..2985760 /gene="pucL" /locus_tag="BSU_32450" /old_locus_tag="BSU32450" /EC_number="1.7.3.3" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11344136, 12823818, 17567580, 20168977, 23760935, 28531234" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344136, 12823818, 17567580, 20168977, 23760935, 28531234; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="urate oxidase with peroxide reductase N-terminaldomain" /protein_id="NP_391125.1" /db_xref="EnsemblGenomes-Gn:BSU32450" /db_xref="EnsemblGenomes-Tr:CAB15235" /db_xref="GOA:O32141" /db_xref="InterPro:IPR002042" /db_xref="InterPro:IPR017580" /db_xref="InterPro:IPR018020" /db_xref="InterPro:IPR019842" /db_xref="InterPro:IPR036778" /db_xref="SubtiList:BG13986" /db_xref="UniProtKB/Swiss-Prot:O32141" /translation="MFTMDDLNQMDTQTLTDTLGSIFEHSSWIAERSAALRPFSSLSD LHRKMTGIVKAADRETQLDLIKKHPRLGTKKTMSDDSVREQQNAGLGKLEQQEYEEFL MLNEHYYDRFGFPFILAVKGKTKQDIHQALLARLESERETEFQQALIEIYRIARFRLA DIITEKGETQMKRTMSYGKGNVFAYRTYLKPLTGVKQIPESSFAGRDNTVVGVDVTCE IGGEAFLPSFTDGDNTLVVATDSMKNFIQRHLASYEGTTTEGFLHYVAHRFLDTYSHM DTITLTGEDIPFEAMPAYEEKELSTSRLVFRRSRNERSRSVLKAERSGNTITITEQYS EIMDLQLVKVSGNSFVGFIRDEYTTLPEDGNRPLFVYLNISWQYENTNDSYASDPARY VAAEQVRDLASTVFHELETPSIQNLIYHIGCRILARFPQLTDVSFQSQNHTWDTVVEE IPGSKGKVYTEPRPPYGFQHFTVTREDAEKEKQKAAEKCRSLKA*" /label="pucL CDS" gene 2984276..2985760 /gene="pucL" /locus_tag="BSU_32450" /old_locus_tag="BSU32450" /label="pucL gene" CDS 2985760..2986104 /gene="pucM" /locus_tag="BSU_32460" /old_locus_tag="BSU32460" /EC_number="3.5.2.17" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11344136, 16098976, 16782815, 21795808" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344136, 16098976, 16782815, 21795808; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5-hydroxyisourate hydrolase; also uricase subunit" /protein_id="NP_391126.2" /db_xref="EnsemblGenomes-Gn:BSU32460" /db_xref="EnsemblGenomes-Tr:CAB15236" /db_xref="GOA:O32142" /db_xref="InterPro:IPR000895" /db_xref="InterPro:IPR014306" /db_xref="InterPro:IPR023416" /db_xref="InterPro:IPR023418" /db_xref="InterPro:IPR023419" /db_xref="InterPro:IPR036817" /db_xref="PDB:2H0E" /db_xref="PDB:2H0F" /db_xref="PDB:2H0J" /db_xref="SubtiList:BG13987" /db_xref="UniProtKB/Swiss-Prot:O32142" /translation="MGKLTTHILDLTCGKPAANVKIGLKRLGESIMKEVYTNNDGRVD VPLLAGEELMSGEYVMEFHAGDYFASKNMNAADQPFLTIVTVRFQLADPDAHYHIPLL LSPFGYQVYRGS*" /label="pucM CDS" gene 2985760..2986104 /gene="pucM" /locus_tag="BSU_32460" /old_locus_tag="BSU32460" /label="pucM gene" promotor_-35 2985826..2985829 /Source="Nicolas_upshift_promotors" /id="U2547" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95104895104895" /psig="0.975024975024975" /xcortree=2067 /SigmaFactorBS="ggcaaaccagcggcgaacgtaaaaattGGATtgaagcggctg ggcgaaAGTATTATGAAAGAGGTATAcactaacaatgacggcagggtcgatgtccctc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2985847..2985866 /Source="Nicolas_upshift_promotors" /id="U2547" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95104895104895" /psig="0.975024975024975" /xcortree=2067 /SigmaFactorBS="ggcaaaccagcggcgaacgtaaaaattGGATtgaagcggctg ggcgaaAGTATTATGAAAGAGGTATAcactaacaatgacggcagggtcgatgtccctc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2985859 /Source="Nicolas_upshifts" /id="U2547" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.95104895104895" /psig="0.975024975024975" /xcortree=2067 /SigmaFactorBS="ggcaaaccagcggcgaacgtaaaaattGGATtgaagcggctg ggcgaaAGTATTATGAAAGAGGTATAcactaacaatgacggcagggtcgatgtccctc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 2986079 /Source="Nicolas_upshifts" /id="D1684" /incds=0 /nref=3 /ntot=90 /MaxReadThrough="1.80149" /MaxDrop="3.57243" /score="20.0549891" /energy="-14.2" /TU="NA" /idTUdmin="U2547" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2986120..2986507) /Source="Nicolas_S_feature" /locus_tag="new_3335006_3335393_c" /HighExp="BT, S8, T2.0H, LBGstat, Cold, Etha, Sw, T1.0H, T1.30H, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1251" promotor_-35 2986467..2986476 /Source="Nicolas_upshift_promotors" /id="U2548" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1423 /SigmaFactorBS="agacaaaatattcattttttcttttttagacttaaATCTATG TCGaaaataatcgttGGCATATCTTATCCTATCTCcactaaaggaggtgacattatgg g" /listShort="yuzJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2986489..2986508 /Source="Nicolas_upshift_promotors" /id="U2548" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1423 /SigmaFactorBS="agacaaaatattcattttttcttttttagacttaaATCTATG TCGaaaataatcgttGGCATATCTTATCCTATCTCcactaaaggaggtgacattatgg g" /listShort="yuzJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2986492 /Source="Nicolas_upshifts" /id="U2548" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.976023976023976" /psig="0.976023976023976" /xcortree=1423 /SigmaFactorBS="agacaaaatattcattttttcttttttagacttaaATCTATG TCGaaaataatcgttGGCATATCTTATCCTATCTCcactaaaggaggtgacattatgg g" /listShort="yuzJ" /GFF_Attribute="listLong" /label="upshifts" ncRNA complement(2986528..2986659) /ncRNA_class="antisense_RNA" /gene="auzJ" /locus_tag="BSU_ncRNA_2" /product="putative antisense RNA for type I YuzJ toxin" /note="Evidence 3: Putative function from multiple computational evidences" /label="auzJ ncRNA" CDS 2986528..2986659 /gene="yuzJ" /locus_tag="BSU_32469" /old_locus_tag="BSU32469" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 20156992, 20525796, 21670523; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative type I toxin" /protein_id="YP_003097780.1" /db_xref="EnsemblGenomes-Gn:BSU32469" /db_xref="EnsemblGenomes-Tr:CAX52686" /db_xref="GOA:C0H3Q7" /db_xref="InterPro:IPR010070" /db_xref="UniProtKB/Swiss-Prot:C0H3Q7" /translation="MGFYNSGGYSGNSGYSNGFGSSFALIVVLFILLIIVGAAIFNY* " /label="yuzJ CDS" gene 2986528..2986659 /gene="yuzJ" /locus_tag="BSU_32469" /old_locus_tag="BSU32469" /label="yuzJ gene" gene complement(2986528..2986659) /gene="auzJ" /locus_tag="BSU_ncRNA_2" /label="auzJ gene" S_feature 2986660..2986728 /Source="Nicolas_S_feature" /locus_tag="new_3335546_3335614" /HighExp="BT, B36, S8, G/S, B60, Pyr, Glucon, C30, S7, Mal" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1252" downshifts 2986695 /Source="Nicolas_upshifts" /id="D1685" /incds=0 /nref=10 /ntot=25 /MaxReadThrough="0.61379" /MaxDrop="6.43101" /score="20.0549891" /energy="-14.2" /TU="NA" /idTUdmin="U2548" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(2986865..2987386) /gene="pucE" /locus_tag="BSU_32470" /old_locus_tag="BSU32470" /EC_number="1.17.1.4" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9098051, 11344136, 18569337; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xanthine dehydrogenase, iron-sulfur subunit" /protein_id="NP_391127.1" /db_xref="EnsemblGenomes-Gn:BSU32470" /db_xref="EnsemblGenomes-Tr:CAB15237" /db_xref="GOA:O32143" /db_xref="InterPro:IPR001041" /db_xref="InterPro:IPR002888" /db_xref="InterPro:IPR006058" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR017611" /db_xref="InterPro:IPR036010" /db_xref="InterPro:IPR036884" /db_xref="SubtiList:BG13988" /db_xref="UniProtKB/Swiss-Prot:O32143" /translation="MDIKEAGPFPVKKEQFRMTVNGQAWEVAAVPTTHLSDLLRKEFQ LTGTKVSCGIGRCGACSILIDGKLANACMTMAYQADGHSITTIEGLQKEELDMCQTAF LEEGGFQCGYCTPGMIIALKALFRETPQPSDKDIEEGLAGNLCRCTGYGGIMRSACRI RRELNGGRRESGF*" /label="pucE CDS" gene complement(2986865..2987386) /gene="pucE" /locus_tag="BSU_32470" /old_locus_tag="BSU32470" /label="pucE gene" CDS complement(2987377..2989614) /gene="pucD" /locus_tag="BSU_32480" /old_locus_tag="BSU32480" /EC_number="1.17.1.4" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9098051, 11344136, 18569337; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xanthine dehydrogenase, substrate and molybdenumcofactor subunit" /protein_id="NP_391128.1" /db_xref="EnsemblGenomes-Gn:BSU32480" /db_xref="EnsemblGenomes-Tr:CAB15238" /db_xref="GOA:O32144" /db_xref="InterPro:IPR000674" /db_xref="InterPro:IPR008274" /db_xref="InterPro:IPR017609" /db_xref="InterPro:IPR036856" /db_xref="InterPro:IPR037165" /db_xref="SubtiList:BG13989" /db_xref="UniProtKB/Swiss-Prot:O32144" /translation="MIINKPSRVRPDGRGKVTGELKYMTDLSFPGMLYGKVLRSAYPH AEIVSVCTIKAEKMEGVQAVVTHKDVPGLNRFGIVIPDQPVLCEDRVRYVGDAIAAVA AETEEIAEAALELIQVEYKELEVMDSPEKALRPNAQRLHEDGNILHRAFFSNGDVEEG FQASDTVFEETYELPRQMHTYMETEGGVAVPEDDGGFTMYAGTQHGYKDRFQLARIFD IPEEKIRIVSSPMGGSFGGKDELNIQPYAALLALKSGRPVKIHQTRKESVRSGIKRHP MKITIKTGADHSGNLLAHDVKIVADTGAYATLGPAVLDFSVEHAAGPYRIPNIRTEGI SVFTNNGVAGEFRGFGGNQITFALETHLDRLSGMLGIDPLELRRKNIRKPHDLGPLEH RIAPTDGAAQVLNAISKSPILKKTSRNCGYLQRGTGAAITMHGGGLGFGRMDAAGGRL SLSSEGKITASFGFEECGQGILAAIEQIVMEELGCAAEDISIVIGDTAKVPKSGSSTA SRGTSMVWHAIQRLKKPFLAQLKKRAAEWSGCSAENLIPGAAGLRDKNTKALVVTYKE LAEKGPLAEETAFDFPTTPDPVVGGHFLYSFGAAAVEVEVDLLTGDVKLIDCEHAIAA GPVVSPQGYRGQIEGGAAMALGYTLMEEAKMTDGRYAAENLDHYLIPGIKDVPDMKLI AIEDLMKGDVYGPRGVGEIGTIAITPAIVKAVHDAVGCWINKLPISREELLEAIDRKG LKQWT*" /label="pucD CDS" gene complement(2987377..2989614) /gene="pucD" /locus_tag="BSU_32480" /old_locus_tag="BSU32480" /label="pucD gene" CDS complement(2989615..2990448) /gene="pucC" /locus_tag="BSU_32490" /old_locus_tag="BSU32490" /EC_number="1.17.1.4" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9098051, 11344136, 18569337; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="xanthine dehydrogenase, FAD-binding subunit" /protein_id="NP_391129.1" /db_xref="EnsemblGenomes-Gn:BSU32490" /db_xref="EnsemblGenomes-Tr:CAB15239" /db_xref="GOA:O32145" /db_xref="InterPro:IPR002346" /db_xref="InterPro:IPR016166" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR017612" /db_xref="InterPro:IPR036318" /db_xref="InterPro:IPR036683" /db_xref="SubtiList:BG13990" /db_xref="UniProtKB/Swiss-Prot:O32145" /translation="MNGQVTKARMNIQLWRPAALDEAYSLLEKLAPDVCAASGSTLLQ LQWDKGTLPKQHLVSLEGIDEMRGISTSDTHVSIGGLTSLNECRKNPLIKRALSCFSD AASAVAAPGIRSRATIGGNIASKIGDFIPLLLVLGAELIVYQKELIRLPLGAWLSEED FRTAIVTRVIIPRAEGERVFYHKLGRRQAFTGAAAVAAGRFLKDGSIRLAAGHADITP RRLLDSEAKWMAPGWDPHELYKTLIHELPFSSDVFMSAAYRKKAAANVIMAELMAEGG E*" /label="pucC CDS" gene complement(2989615..2990448) /gene="pucC" /locus_tag="BSU_32490" /old_locus_tag="BSU32490" /label="pucC gene" CDS complement(2990445..2991062) /gene="pucB" /locus_tag="BSU_32500" /old_locus_tag="BSU32500" /EC_number="2.7.7.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11344136, 21528011; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative molybdopterin cofactor synthesis cytidylyl transferase" /protein_id="NP_391130.2" /db_xref="EnsemblGenomes-Gn:BSU32500" /db_xref="EnsemblGenomes-Tr:CAB15240" /db_xref="GOA:O32146" /db_xref="InterPro:IPR017615" /db_xref="InterPro:IPR025877" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG13991" /db_xref="UniProtKB/Swiss-Prot:O32146" /translation="MRSPYLIGVFLAAGKSRRMGQNKLALPLKGENIGSLSLKTALSS RLDHVLVVERTEHASLEWIGAPYHAPPFQKRWSLHVCQDAEKGQGHSVSSGVRKAESM GADGIVILLADQPQLSVDHLNALVALAPESFAVSSFLGAFTPPIYFSSTCFPYVKGLK GDEGARRLLKSGQLGAGAVLEAKDSGELDDIDTPEEYDMVRRAMS*" /label="pucB CDS" gene complement(2990445..2991062) /gene="pucB" /locus_tag="BSU_32500" /old_locus_tag="BSU32500" /label="pucB gene" downshifts complement(2990554) /Source="Nicolas_upshifts" /id="D1686" /incds=1 /nref=3 /ntot=13 /MaxReadThrough="5.34639" /MaxDrop="3.22355" /score="-4.87239629" /energy="-9.9" /TU="U2549" /idTUdmin="U2549" /TUdmin="-3827" /isTUend="FALSE" /label="downshifts" CDS complement(2991059..2992051) /gene="pucA" /locus_tag="BSU_32510" /old_locus_tag="BSU32510" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10217763, 11344136, 12029039" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10217763, 11344136, 12029039; Product type f: factor" /codon_start=1 /transl_table=11 /product="xanthine dehydrogenase molybdopterin recruitmentfactor" /protein_id="NP_391131.1" /db_xref="EnsemblGenomes-Gn:BSU32510" /db_xref="EnsemblGenomes-Tr:CAB15241" /db_xref="GOA:O32147" /db_xref="InterPro:IPR003777" /db_xref="InterPro:IPR027051" /db_xref="SubtiList:BG13992" /db_xref="UniProtKB/Swiss-Prot:O32147" /translation="MGNFHTMLDALLEDQEEAVLATIVQVEGSAYRKAGASMLFKKKG RRIGLLSGGCVEEDVFQRISALGDQLTSTLIPYDMRSEDDLSWGMGAGCNGIIHVHAE RITQEKRRHYEKVRDCLHSGKAVTSVIKIESSHYLFLTENGHFGNWPDAPLQDIQRTV STLHLPHFDQTTNMFIQRIEPKPRLILFGAGPDNVPLANLAADTGFSVIVTDWRPAYC TSSLFPKADQLITAFPEQMLSEFQFFPHDAAVVATHHYQHDQTIINFLFSQNLHYIGL LGSANRTKRLLSGKHPPSHFYSPVGLKIGAEGPEEIAVSVVAEIIQTRKRVAVV*" /label="pucA CDS" gene complement(2991059..2992051) /gene="pucA" /locus_tag="BSU_32510" /old_locus_tag="BSU32510" /label="pucA gene" S_feature complement(2992052..2992138) /Source="Nicolas_S_feature" /locus_tag="new_3340938_3341024_c" /HighExp="BT, Cold, Sw, T-1.10H, S1, C30, S0, T-0.40H, T-3.40H, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.607" /TUlongSig="NA" /TUlongPSig="NA" /label="S1253" promotor_-10 complement(2992116..2992135) /Source="Nicolas_upshift_promotors" /id="U2549" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.477522477522478" /psig="0.607392607392607" /xcortree=1437 /SigmaFactorBS="ttttacaaatcctctttctatgtgtttcattttctgacaaat caTGAGTCattttttcttccaTCGTCTATTCTTTATACAAGttacctataaaatcacg c" /listShort="S1253, pucA, pucB, pucC, pucD, pucE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(2992138) /Source="Nicolas_upshifts" /id="U2549" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.477522477522478" /psig="0.607392607392607" /xcortree=1437 /SigmaFactorBS="ttttacaaatcctctttctatgtgtttcattttctgacaaat caTGAGTCattttttcttccaTCGTCTATTCTTTATACAAGttacctataaaatcacg c" /listShort="S1253, pucA, pucB, pucC, pucD, pucE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(2992149..2992154) /Source="Nicolas_upshift_promotors" /id="U2549" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.477522477522478" /psig="0.607392607392607" /xcortree=1437 /SigmaFactorBS="ttttacaaatcctctttctatgtgtttcattttctgacaaat caTGAGTCattttttcttccaTCGTCTATTCTTTATACAAGttacctataaaatcacg c" /listShort="S1253, pucA, pucB, pucC, pucD, pucE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(2992280..2993530) /gene="pucG" /locus_tag="BSU_32520" /old_locus_tag="BSU32520" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11344136, 20852637, 28032445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344136, 20852637, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="(S)-ureidoglycine-glyoxylate aminotransferase (PLP-dependent)" /protein_id="NP_391132.1" /db_xref="EnsemblGenomes-Gn:BSU32520" /db_xref="EnsemblGenomes-Tr:CAB15242" /db_xref="GOA:O32148" /db_xref="InterPro:IPR000192" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR020578" /db_xref="InterPro:IPR024169" /db_xref="PDB:3ISL" /db_xref="SubtiList:BG13993" /db_xref="UniProtKB/Swiss-Prot:O32148" /translation="MSGRRELCTPLRTIMTPGPVEVDPRVLRVMSTPVVGQFDPAFTG IMNETMEMLRELFQTKNRWAYPIDGTSRAGIEAVLASVIEPEDDVLIPIYGRFGYLLT EIAERYGANVHMLECEWGTVFDPEDIIREIKKVKPKIVAMVHGETSTGRIHPLKAIGE ACRTEDALFIVDAVATIGGCEVKVDEWKIDAAIGGTQKCLSVPSGMAPITYNERVADV IAARKKVERGIATQADRAALSGNRPITSNYFDLSQLEDYWSERRLNHHTEATTMLYAL REGVRLVLEEGLETRFERHRHHEAALAAGIKAMGLRLFGDDSCKMPVVTCVEIPGGID GESVRDMLLAQFGIEIASSFGPLAGKIWRIGTMGYSCRKENVLFVLAGLEAVLLRHNA GIEAGKALQAALDVYENAGRQAAV*" /label="pucG CDS" gene complement(2992280..2993530) /gene="pucG" /locus_tag="BSU_32520" /old_locus_tag="BSU32520" /label="pucG gene" CDS complement(2993547..2994785) /gene="pucF" /locus_tag="BSU_32530" /old_locus_tag="BSU32530" /EC_number="3.5.3.9" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11344136, 17362992, 25020232; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="allantoate amidohydrolase" /protein_id="NP_391133.1" /db_xref="EnsemblGenomes-Gn:BSU32530" /db_xref="EnsemblGenomes-Tr:CAB15243" /db_xref="GOA:O32149" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR010158" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG13994" /db_xref="UniProtKB/Swiss-Prot:O32149" /translation="MEKQKLSVKNSITDYIEWLAQYGASADGGVTRLLYTKEWMDAQL AVKTEMSSFGLETRFDDVGNVFGRLSGTQSPDEVIVTGSHIDTVINGGKYDGAYGVLA AMLALKQLKETYGAPKKTLEAVSLCEEEGSRFPMTYWGSGNMTGVFSEQDAKEPRDES GVSLQTAMHESGFGKGVFQSAYRTDISAFVELHIEQGKTLEMSGRDLGIVTSIAGQRR YLVTLEGECNHAGTTSMKWRKDPLAASSRIIHELLLRSDELPDELRLTCGKITAEPNV ANVIPGRVQFSIDIRHQHQHVLEQFHQDMVALINGICLQKGIRAVIDEYMRIEPVPMD ERLKAAAFETALENGFSCEEMVSGAGHDAQMIGRRYPACMLFVPSRGGVSHSPKEYTS ARQLEIGVRALTDLLYKLAY*" /label="pucF CDS" gene complement(2993547..2994785) /gene="pucF" /locus_tag="BSU_32530" /old_locus_tag="BSU32530" /label="pucF gene" CDS 2995008..2995145 /locus_tag="BSU_32539" /old_locus_tag="BSU32539" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514002.1" /translation="MNKLSWRGDVRGTDENRNAGSPQKQDLKIWKQEISASSKGTNLQ F*" /label="hypothetical protein CDS" gene 2995008..2995145 /locus_tag="BSU_32539" /old_locus_tag="BSU32539" /label="gene" promotor_-35 2995167..2995170 /Source="Nicolas_upshift_promotors" /id="U2550" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.921078921078921" /psig=1 /xcortree=463 /SigmaFactorBS="ggactaatttacaattttaatgaaaaatatacaaaatgacaC TTCtatcctttatttcaATTTTAGATAATAGATATGAtctgataaaaggagggcaagt g" /listShort="bsn" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2995185..2995204 /Source="Nicolas_upshift_promotors" /id="U2550" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.921078921078921" /psig=1 /xcortree=463 /SigmaFactorBS="ggactaatttacaattttaatgaaaaatatacaaaatgacaC TTCtatcctttatttcaATTTTAGATAATAGATATGAtctgataaaaggagggcaagt g" /listShort="bsn" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2995186 /Source="Nicolas_upshifts" /id="U2550" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.921078921078921" /psig=1 /xcortree=463 /SigmaFactorBS="ggactaatttacaattttaatgaaaaatatacaaaatgacaC TTCtatcctttatttcaATTTTAGATAATAGATATGAtctgataaaaggagggcaagt g" /listShort="bsn" /GFF_Attribute="listLong" /label="upshifts" CDS 2995227..2996093 /gene="bsnA" /locus_tag="BSU_32540" /old_locus_tag="BSU32540" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1396690, 12490701, 12883447, 16291680, 25844442" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1396690, 12490701, 12883447, 16291680, 25844442; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="extracellular ribonuclease" /protein_id="NP_391134.1" /db_xref="EnsemblGenomes-Gn:BSU32540" /db_xref="EnsemblGenomes-Tr:CAB15244" /db_xref="GOA:O32150" /db_xref="InterPro:IPR007346" /db_xref="SubtiList:BG13995" /db_xref="UniProtKB/Swiss-Prot:O32150" /translation="MTKKAWFLPLVCVLLISGWLAPAASASAQTTLSLNDRLASSPSG TGSLLSLAAPAAPYADTDTYYEGAEGKTGDSLKSTLHRIISGHTMLSYSEVWNALKET DEDPRNPNNVILLYTNESRSKNLNGGNVGDWNREHVWAKSHGDFGTSKGPGTDIHHLR PADVQVNSARGNMDFDNGGTEYAKAPGNYYDGDSWEPRDDVKGDVARMLFYMAVRYEG DDGYPDLELNDKTGNGSAPYHGKQSVLLEWNKQDPVDDRERKRNEIIYEKYQHNRNPF IDHPEWADEIWP*" /label="bsnA CDS" gene 2995227..2996093 /gene="bsnA" /locus_tag="BSU_32540" /old_locus_tag="BSU32540" /label="bsnA gene" downshifts 2996096 /Source="Nicolas_upshifts" /id="D1687" /incds=0 /nref=48 /ntot=190 /MaxReadThrough="0.45317" /MaxDrop="6.90997" /score="25.7790712" /energy="-15.5" /TU="NA" /idTUdmin="U2550" /TUdmin=8 /isTUend="TRUE" /label="downshifts" CDS complement(2996127..2997230) /gene="frlP" /locus_tag="BSU_32550" /old_locus_tag="BSU32550" /EC_number="3.6.3.-" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:23175651, 27501980" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23175651, 27501980; Product type t: transporter" /codon_start=1 /transl_table=11 /product="fructose-amino acid ABC transporter (ATP-bindingsubunit)" /protein_id="NP_391135.1" /db_xref="EnsemblGenomes-Gn:BSU32550" /db_xref="EnsemblGenomes-Tr:CAB15245" /db_xref="GOA:O32151" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR008995" /db_xref="InterPro:IPR013611" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG13996" /db_xref="UniProtKB/Swiss-Prot:O32151" /translation="MASLTFEHVKKSYHSQLTVKDFDLDVKDKELLVLVGPSGCGKST TLRMVAGLESISEGNLLIDGERVNDLPPKERDIAMVFQNYALYPHMTVFDNMAFGLKL RKMAKQEIAERVHAAARILEIEHLLKRKPKALSGGQRQRVALGRSIVREPKVFLMDEP LSNLDAKLRVTMRTEISKLHQRLEATIIYVTHDQTEAMTMGDRIVVMNEGEIQQVAKP HDIYHYPANLFVAGFIGSPGMNFLKGIIEQQHGELFFTNSSIRLHIPEEKAKRLKEKG YAGEQMIAGVRPEHITQMTGNDQLFDSVFQANVEVNENLGSELIVHVMAGDERLKVRL DGNTRIDAGDSIQLSVKMDHVVFFDAETEEAVY*" /label="frlP CDS" gene complement(2996127..2997230) /gene="frlP" /locus_tag="BSU_32550" /old_locus_tag="BSU32550" /label="frlP gene" downshifts complement(2996142) /Source="Nicolas_upshifts" /id="D1688" /incds=0 /nref=57 /ntot=215 /MaxReadThrough="3.04361" /MaxDrop="6.06171" /score="29.1144499" /energy="-15.5" /TU="NA" /idTUdmin="U2553" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(2997231..2998164) /Source="Nicolas_S_feature" /locus_tag="new_3346117_3347050_c" /HighExp="HiOs, T-5.40H, T5.0H, GM-0.1, S2, GM-0.2, GM 5, T-4.40H, T4.0H, SMM" /AntisenseName="frlR" /AntisenseCor="0.22682293682100099" /AntisenseRegPval="-3.8" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-, SigA" /TUshortPSig="0.971, 0.456, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1254" promotor_-35 2997268..2997275 /Source="Nicolas_upshift_promotors" /id="U2551" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.743256743256743" /psig="0.996003996003996" /xcortree=3177 /SigmaFactorBS="tccccctatcttttgacccgttatttcgtCACTGGAAacaac ttggtcttTCTGTTATTTTTAGAGTAATcgattcccatttttgctatatttctaaaat a" /listShort="frlR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 2997289..2997308 /Source="Nicolas_upshift_promotors" /id="U2551" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.743256743256743" /psig="0.996003996003996" /xcortree=3177 /SigmaFactorBS="tccccctatcttttgacccgttatttcgtCACTGGAAacaac ttggtcttTCTGTTATTTTTAGAGTAATcgattcccatttttgctatatttctaaaat a" /listShort="frlR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 2997299 /Source="Nicolas_upshifts" /id="U2551" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.743256743256743" /psig="0.996003996003996" /xcortree=3177 /SigmaFactorBS="tccccctatcttttgacccgttatttcgtCACTGGAAacaac ttggtcttTCTGTTATTTTTAGAGTAATcgattcccatttttgctatatttctaaaat a" /listShort="frlR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 2997350..2997356 /Source="Nicolas_upshift_promotors" /id="U2552" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.503496503496504" /psig="0.996003996003996" /xcortree=2434 /SigmaFactorBS="atcgattcccatttttgctatatttctaaaataaaaaatgta aATTTGTAttataacgtcataaTACATTATAATATAAATAATaggttaaaaggaggct a" /listShort="frlR" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 2997367 /Source="Nicolas_upshifts" /id="U2552" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.503496503496504" /psig="0.996003996003996" /xcortree=2434 /SigmaFactorBS="atcgattcccatttttgctatatttctaaaataaaaaatgta aATTTGTAttataacgtcataaTACATTATAATATAAATAATaggttaaaaggaggct a" /listShort="frlR" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 2997371..2997390 /Source="Nicolas_upshift_promotors" /id="U2552" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.503496503496504" /psig="0.996003996003996" /xcortree=2434 /SigmaFactorBS="atcgattcccatttttgctatatttctaaaataaaaaatgta aATTTGTAttataacgtcataaTACATTATAATATAAATAATaggttaaaaggaggct a" /listShort="frlR" /GFF_Attribute="listLong" /label="promotor_-10" CDS 2997412..2998140 /gene="frlR" /locus_tag="BSU_32560" /old_locus_tag="BSU32560" /experiment="publication(s) with functional evidences, PMID:21347729, 21398478, 24673833" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21347729, 21398478, 24673833; Product type r: regulator" /codon_start=1 /transl_table=11 /product="FrlR transcriptional regulator (GntR family)" /protein_id="NP_391136.3" /db_xref="EnsemblGenomes-Gn:BSU32560" /db_xref="EnsemblGenomes-Tr:CAB15246" /db_xref="GOA:O32152" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR011663" /db_xref="InterPro:IPR028978" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2IKK" /db_xref="SubtiList:BG13997" /db_xref="UniProtKB/Swiss-Prot:O32152" /translation="MLNNGSSTPLYIQLKQIITDDIKKGVYSPTAKLPTENELCTKYN VSRITVRKAILDLVEEGYLIRQQGKGTFVKSPKLKRELIAVNGYSEFMESTGKKPKHH VLSHDIIPASKPIAEKLQIQPESPVVELKRILYNDDQPLTFEVTHYPLDLFPGIDTFI ADGVSMHDILKQQYKVVPTHNTKLLNVVYAQQEESKYLDCDIGDALFEIDKTAFTSND QPIYCSLFLMHTNRVTFTINSPYT*" /label="frlR CDS" gene 2997412..2998140 /gene="frlR" /locus_tag="BSU_32560" /old_locus_tag="BSU32560" /label="frlR gene" CDS complement(2998165..2999019) /gene="frlD" /locus_tag="BSU_32570" /old_locus_tag="BSU32570" /EC_number="2.7.1.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 14641112, 15556630, 16153181, 21347729, 21398478, 22720735; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="fructoselysine kinase" /protein_id="NP_391137.1" /db_xref="EnsemblGenomes-Gn:BSU32570" /db_xref="EnsemblGenomes-Tr:CAB15247" /db_xref="GOA:O32153" /db_xref="InterPro:IPR002173" /db_xref="InterPro:IPR011611" /db_xref="InterPro:IPR029056" /db_xref="SubtiList:BG13998" /db_xref="UniProtKB/Swiss-Prot:O32153" /translation="MKLIAVGDNVVDYYQDQETFYPGGNALNVAVLAKRLGHESSYIG IVGNDEAAAHLLNVLKLEQVNADYIRQAHGENGMAIVTLDEQGDRIFVRSNKGGIQSR LRLAFQEKDVSFISGHDLLHTSVYSRLENDLPQLCGLVPVSFDFSTNREDDYLRRVCP YVTYAFFSGSDLSESECGELAKTAHGYGAKMVCMTRGGQGAILSAGDRVYHQPIVEAD IIDTLGAGDSFIAGFLTAFCVKQDITYALRQAAETAAKTCGVYGAFGYGYPYRLEDGG SSEKTRIL*" /label="frlD CDS" gene complement(2998165..2999019) /gene="frlD" /locus_tag="BSU_32570" /old_locus_tag="BSU32570" /label="frlD gene" misc_feature complement(2998352..2998371) /Source="Nicolas_upshift_promotors" /id="U2553" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.77022977022977" /psig="0.971028971028971" /xcortree=571 /SigmaFactorBS="aaggagcaatcctgtctgcgggtgatcgagtctatcatcagc cgattgtggaaGCTGATATAATAGATACACTtggagcgggagattcttttatagcagg c" /listShort="S1254, yurJ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(2998364) /Source="Nicolas_upshifts" /id="U2553" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.77022977022977" /psig="0.971028971028971" /xcortree=571 /SigmaFactorBS="aaggagcaatcctgtctgcgggtgatcgagtctatcatcagc cgattgtggaaGCTGATATAATAGATACACTtggagcgggagattcttttatagcagg c" /listShort="S1254, yurJ" /GFF_Attribute="listLong" /label="upshifts" promotor_no_box complement(2998522..2998622) /Source="Nicolas_upshift_promotors" /id="U2554" /multdbtbs="-" /comp="M19" /sig="Sig-" /pcomp="0.320679320679321" /psig="0.455544455544456" /xcortree=1631 /SigmaFactorBS="ttccgcagctgtgcgggctggtcccggtctcatttgattttt caaccaatcgggaggatgattatttgaggagggtctgtccttatgtgacgtatgcgtt t" /listShort="S1254, yurJ" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(2998562) /Source="Nicolas_upshifts" /id="U2554" /multdbtbs="-" /comp="M19" /sig="Sig-" /pcomp="0.320679320679321" /psig="0.455544455544456" /xcortree=1631 /SigmaFactorBS="ttccgcagctgtgcgggctggtcccggtctcatttgattttt caaccaatcgggaggatgattatttgaggagggtctgtccttatgtgacgtatgcgtt t" /listShort="S1254, yurJ" /GFF_Attribute="listLong" /label="upshifts" CDS complement(2999033..2999935) /gene="frlM" /locus_tag="BSU_32580" /old_locus_tag="BSU32580" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12618455, 15849754, 16850406, 15556630, 21347729; Product type t : transporter" /codon_start=1 /transl_table=11 /product="fructose-amino acid permease" /protein_id="NP_391138.1" /db_xref="EnsemblGenomes-Gn:BSU32580" /db_xref="EnsemblGenomes-Tr:CAB15248" /db_xref="GOA:O32154" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG13999" /db_xref="UniProtKB/Swiss-Prot:O32154" /translation="MLPQKKTDSFRLEPVPDQHIEVKDKPRRKWYIGETSVWVFLFLY LIAIAYPLLWMVMSAFKNSDDIFEHSWSLPSSWHPENFVSAWNQGISSYFMNSVIVTA LTCVITVFISAWAAYGLSRFEFKGKGFFLVLCLGGLMLTPQVSLVPLYSIIQSLGLYN TYWALILPYAAYRIPFTIILIRSYFLSISKELEEAAYLDGCTSFGVFFRIFLPMSVPI LVTSGILTAYHTWNEFMFAIIFIDDENLRTIPAGLMQFRDALQTDWGVLLAGLTISAA PIIILFLLMQKYFVRGIASGSVKG*" /label="frlM CDS" gene complement(2999033..2999935) /gene="frlM" /locus_tag="BSU_32580" /old_locus_tag="BSU32580" /label="frlM gene" CDS complement(2999939..3000817) /gene="frlN" /locus_tag="BSU_32590" /old_locus_tag="BSU32590" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12618455, 15849754, 16850406, 15556630, 21347729; Product type t : transporter" /codon_start=1 /transl_table=11 /product="fructose-amino acid permease" /protein_id="NP_391139.1" /db_xref="EnsemblGenomes-Gn:BSU32590" /db_xref="EnsemblGenomes-Tr:CAB15249" /db_xref="GOA:O32155" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035277" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG14000" /db_xref="UniProtKB/Swiss-Prot:O32155" /translation="MVNQNKIIPYLFLVPALVFLLFVYIPIFENVFLSLFQWSSFSPE KTFIGLKNYVELFHDPVFYQALTNNVLYAVISIVCQVFGGLILAAVLEDKLVRKWSPF FRTVFFLPVVISMTVIALLFDFIYNPETGLLNQLLQAIGLDQLTRAWLGDDSTAMLSV IFVSQWQSVGYIAMLYIVSIQKIPDELYEAARLDGAGKIQQFFHITVPQTKEMSFVAV VMTLTGAFTVFNEPYILTGGGPGKASEVLSTFLYKSAFTKDMMGYASAIATVVLIITL ALSLMQMKFFKTGKEE*" /label="frlN CDS" gene complement(2999939..3000817) /gene="frlN" /locus_tag="BSU_32590" /old_locus_tag="BSU32590" /label="frlN gene" CDS complement(3000875..3002143) /gene="frlO" /locus_tag="BSU_32600" /old_locus_tag="BSU32600" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12618455, 21347729; Product type t: transporter" /codon_start=1 /transl_table=11 /product="fructose amino acid-binding lipoprotein" /protein_id="NP_391140.1" /db_xref="EnsemblGenomes-Gn:BSU32600" /db_xref="EnsemblGenomes-Tr:CAB15250" /db_xref="GOA:O32156" /db_xref="InterPro:IPR006059" /db_xref="SubtiList:BG14001" /db_xref="UniProtKB/Swiss-Prot:O32156" /translation="MKKMLLFLIIAAVSMLTIAGCSSQSSSADGKVTLKFFHRWPKEP EKSYFEEVVKEFEKDHPDIDIQIEAVLNDSYKDKIKVMLGTTSPPDIYFSWSDEFAFK FIRGNKALDLSSYYKNDTDWSSQLVQSQITPFTYENKQYGVPWQMDAKSFFYNKDIFQ KLNLDPPKTWDELIDVSKKLKEHGYTPISFGTKATWTISHYIGTLNQRMVDEKTREKD YNAKTGEFTDEGYVKALEKLQELMPYFNKHVNSVDHEYVRQQFKSGKSAMIYAETAEI KLVEPVNLGMFPFPEISGQKGSSEALTGAPEGFMISSRTKHPKEAMEFLQFLTSKRMG EKLVKDVGKYSAVQGTATEENATAIQREAVQHIVDAKSMVPWFDMDVDVEVADAYLTG VQQMLGGDMTPQQVMKAVQKAAKQVRASAE*" /label="frlO CDS" gene complement(3000875..3002143) /gene="frlO" /locus_tag="BSU_32600" /old_locus_tag="BSU32600" /label="frlO gene" promotor_no_box 3002034..3002134 /Source="Nicolas_upshift_promotors" /id="U2555" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.99100899100899" /psig="0.000999000999001" /xcortree=21 /SigmaFactorBS="aaaaatttcaatgtcacctttccgtccgctgaactgctttgg ctcgaacagcctgcgatggtgagcatactgacagctgcaatgatcaagaacaacaaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 3002094 /Source="Nicolas_upshifts" /id="U2555" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.99100899100899" /psig="0.000999000999001" /xcortree=21 /SigmaFactorBS="aaaaatttcaatgtcacctttccgtccgctgaactgctttgg ctcgaacagcctgcgatggtgagcatactgacagctgcaatgatcaagaacaacaaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(3002214) /Source="Nicolas_upshifts" /id="D1689" /incds=0 /nref=21 /ntot=141 /MaxReadThrough="7.96763" /MaxDrop="4.994" /score="3.53212058" /energy="-13.8" /TU="U2557" /idTUdmin="U2558" /TUdmin=1210 /isTUend="FALSE" /label="downshifts" CDS complement(3002224..3003210) /gene="frlB" /locus_tag="BSU_32610" /old_locus_tag="BSU32610" /EC_number="3.5.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 12618455, 15556630, 16153181, 18083814, 21347729, 21398478, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fructosamine-6-P deglycase" /protein_id="NP_391141.1" /db_xref="EnsemblGenomes-Gn:BSU32610" /db_xref="EnsemblGenomes-Tr:CAB15251" /db_xref="GOA:O32157" /db_xref="InterPro:IPR001347" /db_xref="InterPro:IPR024713" /db_xref="InterPro:IPR035488" /db_xref="InterPro:IPR035490" /db_xref="PDB:3EUA" /db_xref="SubtiList:BG14002" /db_xref="UniProtKB/Swiss-Prot:O32157" /translation="MSQATAKVNREVQAFLQDLKGKTIDHVFFVACGGSSAIMYPSKY VFDRESKSINSDLYSANEFIQRNPVQLGEKSLVILCSHSGNTPETVKAAAFARGKGAL TIAMTFKPESPLAQEAQYVAQYDWGDEALAINTNYGVLYQIVFGTLQVLENNTKFEQA IEGLDQLQAVYEKALKQEADNAKQFAKAHEKESIIYTMASGANYGVAYSYSICILMEM QWIHSHAIHAGEYFHGPFEIIDESVPFIILLGLDETRPLEERALTFSKKYGKKLTVLD AASYDFTAIDDSVKGYLAPLVLNRVLRSYADELAEERNHPLSHRRYMWKVEY*" /label="frlB CDS" gene complement(3002224..3003210) /gene="frlB" /locus_tag="BSU_32610" /old_locus_tag="BSU32610" /label="frlB gene" upshifts 3003157 /Source="Nicolas_upshifts" /id="U2556" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.972027972027972" /psig="0.002997002997003" /xcortree=22 /SigmaFactorBS="aatggcagaagaccctccgcatgcgacaaagaatacatgatc aatggttttccctttcaaatcCTGCAagaaagcttgaacctcacgatttacttttgct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 3003160..3003164 /Source="Nicolas_upshift_promotors" /id="U2556" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.972027972027972" /psig="0.002997002997003" /xcortree=22 /SigmaFactorBS="aatggcagaagaccctccgcatgcgacaaagaatacatgatc aatggttttccctttcaaatcCTGCAagaaagcttgaacctcacgatttacttttgct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(3003253..3003272) /Source="Nicolas_upshift_promotors" /id="U2557" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2897 /SigmaFactorBS="cgaataaattattgagaaatttcagaaaataaTATTGACAat cctacccgcggaCTTTAATATAACAATATATAatgttatataacgttatataataaaa a" /listShort="frlB, frlO, frlN, frlM, frlD, S1254, yurJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3003266) /Source="Nicolas_upshifts" /id="U2557" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2897 /SigmaFactorBS="cgaataaattattgagaaatttcagaaaataaTATTGACAat cctacccgcggaCTTTAATATAACAATATATAatgttatataacgttatataataaaa a" /listShort="frlB, frlO, frlN, frlM, frlD, S1254, yurJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3003287..3003294) /Source="Nicolas_upshift_promotors" /id="U2557" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2897 /SigmaFactorBS="cgaataaattattgagaaatttcagaaaataaTATTGACAat cctacccgcggaCTTTAATATAACAATATATAatgttatataacgttatataataaaa a" /listShort="frlB, frlO, frlN, frlM, frlD, S1254, yurJ" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3003424) /Source="Nicolas_upshifts" /id="D1690" /incds=0 /nref=116 /ntot=274 /MaxReadThrough="0.87627" /MaxDrop="5.35981" /score="3.53212058" /energy="-13.8" /TU="NA" /idTUdmin="U2558" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3003426..3003800) /gene="yurQ" /locus_tag="BSU_32620" /old_locus_tag="BSU32620" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative excinuclease" /protein_id="NP_391142.1" /db_xref="EnsemblGenomes-Gn:BSU32620" /db_xref="EnsemblGenomes-Tr:CAB15252" /db_xref="GOA:O32158" /db_xref="InterPro:IPR000305" /db_xref="InterPro:IPR014527" /db_xref="InterPro:IPR035901" /db_xref="SubtiList:BG14003" /db_xref="UniProtKB/Swiss-Prot:O32158" /translation="MIKIDIPAPNVTITERQQSANDNEPKIKPIHGFIDFHQIPRDKG GIFMFYNIHDELLFVGKARKLRQRIKKHFEDTVSPIKHHRDEVYKIEVCVVDDPMERE IYETYIINTQHSKYNIDKVFFK*" /label="yurQ CDS" gene complement(3003426..3003800) /gene="yurQ" /locus_tag="BSU_32620" /old_locus_tag="BSU32620" /label="yurQ gene" upshifts complement(3003864) /Source="Nicolas_upshifts" /id="U2558" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.765234765234765" /psig="0.765234765234765" /xcortree=807 /SigmaFactorBS="tccagccggagcacttgcataaTAAGTAAgagcatgacaaac AAATATAATAAAgctgttctagcttttcttttctgtatgtgttagcatttatctttaa t" /listShort="yurQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3003871..3003882) /Source="Nicolas_upshift_promotors" /id="U2558" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.765234765234765" /psig="0.765234765234765" /xcortree=807 /SigmaFactorBS="tccagccggagcacttgcataaTAAGTAAgagcatgacaaac AAATATAATAAAgctgttctagcttttcttttctgtatgtgttagcatttatctttaa t" /listShort="yurQ" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3003896..3003902) /Source="Nicolas_upshift_promotors" /id="U2558" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.765234765234765" /psig="0.765234765234765" /xcortree=807 /SigmaFactorBS="tccagccggagcacttgcataaTAAGTAAgagcatgacaaac AAATATAATAAAgctgttctagcttttcttttctgtatgtgttagcatttatctttaa t" /listShort="yurQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3003903..3005021) /gene="dadA" /locus_tag="BSU_32630" /old_locus_tag="BSU32630" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 13914427, 16245349, 22271930, 24826896; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-amino acid oxidase" /protein_id="NP_391143.1" /db_xref="EnsemblGenomes-Gn:BSU32630" /db_xref="EnsemblGenomes-Tr:CAB15253" /db_xref="GOA:O32159" /db_xref="InterPro:IPR006076" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG14004" /db_xref="UniProtKB/Swiss-Prot:O32159" /translation="MKSYIIVGAGILGASTAYHLAKTGARVTVIDRKEPGQATDAAAG IVCPWLSQRRNQDWYQLAKGGARYYKDLIHQLEKDGESDTGYKRVGAISIHTDASKLD KMEERAYKRREDAPEIGDITRLSASETKKLFPILADGYESVHISGAARVNGRALCRSL LSAAEKRGATVIKGNASLLFENGTVTGVQTDTKQFAADAVIVTAGAWANEILKPLGIH FQVSFQKAQIMHFEMTDADTGSWPVVMPPSDQYILSFDNGRIVAGATHENDAGLDDLR VTAGGQHEVLSKALAVAPGLADAAAVETRVGFRPFTPGFLPVVGAVPNVQGLYAANGL GASGLTMGPFLGAELAKLVLGKQTELDLSPYDPAGALA*" /label="dadA CDS" gene complement(3003903..3005021) /gene="dadA" /locus_tag="BSU_32630" /old_locus_tag="BSU32630" /label="dadA gene" promotor_-10 complement(3005046..3005065) /Source="Nicolas_upshift_promotors" /id="U2559" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=1879 /SigmaFactorBS="tcgcggtttttccacattagggcaaaaGGTCGAAggaaagca tttgaTTTGGTAAAATGAATAGACAttataatagaaaaggtgtttgcatatgaaatcg t" /listShort="yurR, yurQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3005052) /Source="Nicolas_upshifts" /id="U2559" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=1879 /SigmaFactorBS="tcgcggtttttccacattagggcaaaaGGTCGAAggaaagca tttgaTTTGGTAAAATGAATAGACAttataatagaaaaggtgtttgcatatgaaatcg t" /listShort="yurR, yurQ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3005054..3005664) /Source="Nicolas_S_feature" /locus_tag="new_3353940_3354550_c" /HighExp="G135, H2O2, G180, Paraq, G150, Oxctl, LBGexp, Salt, dia15, Diami" /AntisenseName="yurS" /AntisenseCor="-0.14245591415946501" /AntisenseRegPval="-1.7" /CDS_PredictionProba="0.95340499999999995" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S1255" promotor_-35 complement(3005079..3005085) /Source="Nicolas_upshift_promotors" /id="U2559" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.524475524475524" /psig="0.996003996003996" /xcortree=1879 /SigmaFactorBS="tcgcggtttttccacattagggcaaaaGGTCGAAggaaagca tttgaTTTGGTAAAATGAATAGACAttataatagaaaaggtgtttgcatatgaaatcg t" /listShort="yurR, yurQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3005118..3005127 /Source="Nicolas_upshift_promotors" /id="U2560" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=1408 /SigmaFactorBS="cttttgccctaatgtggaaaaaccgcgaagttcGTCCAATCT CtttactctcctatCGAATATCCTGTCACTATCAatagagaaaggatgataccatgag c" /listShort="sspG, yurS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3005141..3005160 /Source="Nicolas_upshift_promotors" /id="U2560" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=1408 /SigmaFactorBS="cttttgccctaatgtggaaaaaccgcgaagttcGTCCAATCT CtttactctcctatCGAATATCCTGTCACTATCAatagagaaaggatgataccatgag c" /listShort="sspG, yurS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3005145 /Source="Nicolas_upshifts" /id="U2560" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.975024975024975" /psig="0.975024975024975" /xcortree=1408 /SigmaFactorBS="cttttgccctaatgtggaaaaaccgcgaagttcGTCCAATCT CtttactctcctatCGAATATCCTGTCACTATCAatagagaaaggatgataccatgag c" /listShort="sspG, yurS" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3005158..3005173) /Source="Nicolas_upshift_promotors" /id="U2561" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.966033966033966" /psig="0.026973026973027" /xcortree=688 /SigmaFactorBS="catcgcgtctgttttcttcattttcatgacgattttcgCTCA TggtatcATCCTTTCTCTATTGAtagtgacaggatattcgataggagagtaaagagat t" /listShort="yurR, yurQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3005162) /Source="Nicolas_upshifts" /id="U2561" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.966033966033966" /psig="0.026973026973027" /xcortree=688 /SigmaFactorBS="catcgcgtctgttttcttcattttcatgacgattttcgCTCA TggtatcATCCTTTCTCTATTGAtagtgacaggatattcgataggagagtaaagagat t" /listShort="yurR, yurQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3005180..3005184) /Source="Nicolas_upshift_promotors" /id="U2561" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.966033966033966" /psig="0.026973026973027" /xcortree=688 /SigmaFactorBS="catcgcgtctgttttcttcattttcatgacgattttcgCTCA TggtatcATCCTTTCTCTATTGAtagtgacaggatattcgataggagagtaaagagat t" /listShort="yurR, yurQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3005180..3005326 /gene="sspG" /locus_tag="BSU_32640" /old_locus_tag="BSU32640" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:9852018" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9852018; Product type f : factor" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="YP_054592.1" /db_xref="EnsemblGenomes-Gn:BSU32640" /db_xref="EnsemblGenomes-Tr:CAE01466" /db_xref="GOA:Q7WY59" /db_xref="SubtiList:BG14173" /db_xref="UniProtKB/Swiss-Prot:Q7WY59" /translation="MSENRHENEENRRDAAVAKVQNSGNAKVVVSVNTDQDQAQAQSQ DGED*" /label="sspG CDS" gene 3005180..3005326 /gene="sspG" /locus_tag="BSU_32640" /old_locus_tag="BSU32640" /label="sspG gene" CDS 3005326..3005601 /gene="yurS" /locus_tag="BSU_32650" /old_locus_tag="BSU32650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 9852018" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391144.1" /db_xref="EnsemblGenomes-Gn:BSU32650" /db_xref="EnsemblGenomes-Tr:CAB15254" /db_xref="SubtiList:BG14005" /db_xref="UniProtKB/Swiss-Prot:O32160" /translation="MNENIIPLNRHTQEIPTTESVIKNSGNSEVHIDIHIDTMPIAFA ILCSALAAKQMTKEEFDMAYTQLREMNRENNSRSSVKQIINQETEEE*" /label="yurS CDS" gene 3005326..3005601 /gene="yurS" /locus_tag="BSU_32650" /old_locus_tag="BSU32650" /label="yurS gene" upshifts complement(3005470) /Source="Nicolas_upshifts" /id="U2562" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.954045954045954" /psig="0.011988011988012" /xcortree=692 /SigmaFactorBS="ctcgcaattgagtataaGCCATatcgaattCCTCTTTTGTCA TCTgctttgcggctaatgcagagcataatatagcaaaagcaattggcattgtatcaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3005486..3005500) /Source="Nicolas_upshift_promotors" /id="U2562" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.954045954045954" /psig="0.011988011988012" /xcortree=692 /SigmaFactorBS="ctcgcaattgagtataaGCCATatcgaattCCTCTTTTGTCA TCTgctttgcggctaatgcagagcataatatagcaaaagcaattggcattgtatcaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3005509..3005513) /Source="Nicolas_upshift_promotors" /id="U2562" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.954045954045954" /psig="0.011988011988012" /xcortree=692 /SigmaFactorBS="ctcgcaattgagtataaGCCATatcgaattCCTCTTTTGTCA TCTgctttgcggctaatgcagagcataatatagcaaaagcaattggcattgtatcaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3005581 /Source="Nicolas_upshifts" /id="D1691" /incds=0 /nref=36 /ntot=86 /MaxReadThrough="1.84089" /MaxDrop="7.4989" /score="15.0184762" /energy="-11" /TU="NA" /idTUdmin="U2560" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" CDS complement(3005665..3006048) /gene="glxB" /locus_tag="BSU_32660" /old_locus_tag="BSU32660" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10882093, 24330391" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10882093, 24330391; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylglyoxalase; lactoylbacillithiol lyase" /protein_id="NP_391145.1" /db_xref="EnsemblGenomes-Gn:BSU32660" /db_xref="EnsemblGenomes-Tr:CAB15255" /db_xref="GOA:O32161" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG14006" /db_xref="UniProtKB/Swiss-Prot:O32161" /translation="MKIVVTSIFVQDQDMALEFYTEKLGFIKKEDVPMGKFRWITLVS PDDQDGTELLLEPNEHPAAKEYQKKIFSEGLPATMFGVADIQKEYNRLKEKGVTFTTE PTKMGEVTIAVFDDTCGNLIQIVQK*" /label="glxB CDS" gene complement(3005665..3006048) /gene="glxB" /locus_tag="BSU_32660" /old_locus_tag="BSU32660" /label="glxB gene" S_feature complement(3006049..3006158) /Source="Nicolas_S_feature" /locus_tag="new_3354935_3355044_c" /HighExp="Salt, G180, H2O2, Paraq, G135, G150, LBGexp, LBGstat, dia15, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA" /TUlongPSig="1, 1" /label="S1256" CDS complement(3006159..3006437) /gene="yuzN" /locus_tag="BSU_32669" /old_locus_tag="BSU32669" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="YP_003097781.1" /db_xref="EnsemblGenomes-Gn:BSU32669" /db_xref="EnsemblGenomes-Tr:CAX52687" /db_xref="GOA:C0H3Q8" /db_xref="InterPro:IPR001845" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="UniProtKB/Swiss-Prot:C0H3Q8" /translation="MNGNKDAIFKALGDSTRRLILDELSERNELTLYELTIRLITKYD LSITRQAIAKHLSVLEDAGLVTSKRKGKYRVLIFNNEPLKNLLKGWIE*" /label="yuzN CDS" gene complement(3006159..3006437) /gene="yuzN" /locus_tag="BSU_32669" /old_locus_tag="BSU32669" /label="yuzN gene" promotor_-10 complement(3006435..3006454) /Source="Nicolas_upshift_promotors" /id="U2563" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=2701 /SigmaFactorBS="ggataggttcagtttctatatcacgcaaccatacagttgctt aTACTTGACatgcaactaatgggTTGCTTATACTCAATATATGaatgggaacaaagac g" /listShort="yuzN, S1256, yurT, S1255, yurR, yurQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3006459) /Source="Nicolas_upshifts" /id="U2563" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=2701 /SigmaFactorBS="ggataggttcagtttctatatcacgcaaccatacagttgctt aTACTTGACatgcaactaatgggTTGCTTATACTCAATATATGaatgggaacaaagac g" /listShort="yuzN, S1256, yurT, S1255, yurR, yurQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3006469..3006476) /Source="Nicolas_upshift_promotors" /id="U2563" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.846153846153846" /psig=1 /xcortree=2701 /SigmaFactorBS="ggataggttcagtttctatatcacgcaaccatacagttgctt aTACTTGACatgcaactaatgggTTGCTTATACTCAATATATGaatgggaacaaagac g" /listShort="yuzN, S1256, yurT, S1255, yurR, yurQ" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3006600..3006706) /Source="Nicolas_S_feature" /locus_tag="new_3355486_3355592_c" /HighExp="Sw, BI, LPhT, C90, BC, M0t45, Gly, Cold, H2O2, M40t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 0.994" /TUlongSig="SigGF" /TUlongPSig="0.999" /label="S1257" downshifts complement(3006643) /Source="Nicolas_upshifts" /id="D1692" /incds=0 /nref=189 /ntot=303 /MaxReadThrough="3.22318" /MaxDrop="7.82118" /score="0.760415296" /energy="-10.1" /TU="U2564" /idTUdmin="U2565" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" CDS complement(3006707..3008104) /gene="sufB" /locus_tag="BSU_32670" /old_locus_tag="BSU32670" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 16109955, 16431905, 16621837, 20097860" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16109955, 16431905, 16621837, 20097860; Product type f: factor" /codon_start=1 /transl_table=11 /product="FeS cluster formation scaffold protein" /protein_id="NP_391146.1" /db_xref="EnsemblGenomes-Gn:BSU32670" /db_xref="EnsemblGenomes-Tr:CAB15256" /db_xref="GOA:O32162" /db_xref="InterPro:IPR000825" /db_xref="InterPro:IPR010231" /db_xref="SubtiList:BG14007" /db_xref="UniProtKB/Swiss-Prot:O32162" /translation="MAKKMPDIGEYKYGFHDKDVSIFRSERGLTKEIVEEISRMKEEP QWMLDFRLKSLEHFYNMPMPQWGGDLNSLNFDEITYYVKPSERSERSWDEVPEEIKQT FDKLGIPEAEQKYLAGVSAQYESEVVYHNMKEDLEAQGIVFKDTDSALKENEDIFREH WAKVIPPTDNKFAALNSAVWSGGSFIYVPKGVKVETPLQAYFRINSENMGQFERTLII VDEEASVHYVEGCTAPVYTTNSLHSAVVEIIVKKGGYCRYTTIQNWANNVYNLVTKRT VCEENATMEWIDGNIGSKLTMKYPACILKGEGARGMTLSIALAGKGQHQDAGAKMIHL APNTSSTIVSKSISKQGGKVTYRGIVHFGRKAEGARSNIECDTLIMDNKSTSDTIPYN EILNDNISLEHEAKVSKVSEEQLFYLMSRGISEEEATEMIVMGFIEPFTKELPMEYAV EMNRLIKFEMEGSIG*" /label="sufB CDS" gene complement(3006707..3008104) /gene="sufB" /locus_tag="BSU_32670" /old_locus_tag="BSU32670" /label="sufB gene" downshifts 3007902 /Source="Nicolas_upshifts" /id="D1693" /incds=1 /nref=1 /ntot=150 /MaxReadThrough="2.66718" /MaxDrop="3.75483" /score="-4.89805724" /energy="-5" /TU="NA" /idTUdmin="U2560" /TUdmin=2310 /isTUend="FALSE" /label="downshifts" CDS complement(3008125..3008568) /gene="sufU" /locus_tag="BSU_32680" /old_locus_tag="BSU32680" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 16877383, 20097860, 21236255, 24321018, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16877383, 20097860, 21236255, 24321018, 22720735; Product type f : factor" /codon_start=1 /transl_table=11 /product="iron-sulfur cluster assembly sulfur-transfer protein (Zn(2+)-dependent)" /protein_id="NP_391147.1" /db_xref="EnsemblGenomes-Gn:BSU32680" /db_xref="EnsemblGenomes-Tr:CAB15257" /db_xref="GOA:O32163" /db_xref="InterPro:IPR002871" /db_xref="PDB:1XJS" /db_xref="PDB:2AZH" /db_xref="SubtiList:BG14008" /db_xref="UniProtKB/Swiss-Prot:O32163" /translation="MSFNANLDTLYRQVIMDHYKNPRNKGVLNDSIVVDMNNPTCGDR IRLTMKLDGDIVEDAKFEGEGCSISMASASMMTQAIKGKDIETALSMSKIFSDMMQGK EYDDSIDLGDIEALQGVSKFPARIKCATLSWKALEKGVAKEEGGN*" /label="sufU CDS" gene complement(3008125..3008568) /gene="sufU" /locus_tag="BSU_32680" /old_locus_tag="BSU32680" /label="sufU gene" CDS complement(3008558..3009778) /gene="sufS" /locus_tag="BSU_32690" /old_locus_tag="BSU32690" /EC_number="2.8.1.7" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 12876288, 14644425, 15901727, 20822158, 21236255, 27382962" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 12876288, 14644425, 15901727, 20822158, 21236255, 27382962; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cysteine desulfurase" /protein_id="NP_391148.1" /db_xref="EnsemblGenomes-Gn:BSU32690" /db_xref="EnsemblGenomes-Tr:CAB15258" /db_xref="GOA:O32164" /db_xref="InterPro:IPR000192" /db_xref="InterPro:IPR010970" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR016454" /db_xref="InterPro:IPR020578" /db_xref="PDB:5J8Q" /db_xref="SubtiList:BG14009" /db_xref="UniProtKB/Swiss-Prot:O32164" /translation="MNITDIREQFPILHQQVNGHDLVYLDSAATSQKPRAVIETLDKY YNQYNSNVHRGVHTLGTRATDGYEGAREKVRKFINAKSMAEIIFTKGTTTSLNMVALS YARANLKPGDEVVITYMEHHANIIPWQQAVKATGATLKYIPLQEDGTISLEDVRETVT SNTKIVAVSHVSNVLGTVNPIKEMAKIAHDNGAVIVVDGAQSTPHMKIDVQDLDCDFF ALSSHKMCGPTGVGVLYGKKALLENMEPAEFGGEMIDFVGLYESTWKELPWKFEAGTP IIAGAIGLGAAIDFLEEIGLDEISRHEHKLAAYALERFRQLDGVTVYGPEERAGLVTF NLDDVHPHDVATVLDAEGIAVRAGHHCAQPLMKWLDVTATARASFYLYNTEEEIDKLV EALQKTKEYFTNVF*" /label="sufS CDS" gene complement(3008558..3009778) /gene="sufS" /locus_tag="BSU_32690" /old_locus_tag="BSU32690" /label="sufS gene" CDS complement(3009778..3011091) /gene="sufD" /locus_tag="BSU_32700" /old_locus_tag="BSU32700" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 16109955, 16431905, 16621837, 19187533, 20097860, 28839209; Product type f: factor" /codon_start=1 /transl_table=11 /product="Fe-S cluster assembly protein SufD" /protein_id="NP_391149.1" /db_xref="EnsemblGenomes-Gn:BSU32700" /db_xref="EnsemblGenomes-Tr:CAB15259" /db_xref="GOA:O32165" /db_xref="InterPro:IPR000825" /db_xref="InterPro:IPR011542" /db_xref="SubtiList:BG14010" /db_xref="UniProtKB/Swiss-Prot:O32165" /translation="MTLGTKLSVDQEYLKSFSEKHQEPAWLKNLRLQALEQAEDLPMP KPDKTKITNWNFTNFAKHTVDNEPLSSLEDLTDEVKALIDIENEDKTLYVQRDQTPAH LSLSQELKDKGVIFTDILTAAREHSDLVEKYFMKDGVKVDEHKLTALHAALVNGGAFL YVPKNVQVETPVQAVYVHESNDTALFNHVLIVAEDHSSVTYVENYISTVNPKDAVFNI ISEVITGDNASVTYGAVDNLSSGVTTYVNRRGAARGRDSKIEWALGLMNDGDTISENT TNLYGDGTYGDTKTVVVGRGEQTENFTTQIIHFGKASEGYILKHGVMKDSASSIFNGI GKIEHGASKANAEQESRVLMLSEKARGDANPILLIDEDDVTAGHAASVGRVDPIQLYY LMSRGIPKEEAERLVIYGFLAPVVNELPIEGVKKQLVSVIERKVK*" /label="sufD CDS" gene complement(3009778..3011091) /gene="sufD" /locus_tag="BSU_32700" /old_locus_tag="BSU32700" /label="sufD gene" CDS complement(3011109..3011894) /gene="sufC" /locus_tag="BSU_32710" /old_locus_tag="BSU32710" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 16431905, 20097860, 28839209" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16431905, 20097860, 28839209; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sulfur mobilizing ABC protein, ATPase" /protein_id="NP_391150.1" /db_xref="EnsemblGenomes-Gn:BSU32710" /db_xref="EnsemblGenomes-Tr:CAB15260" /db_xref="GOA:P80866" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR010230" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG14011" /db_xref="UniProtKB/Swiss-Prot:P80866" /translation="MAASTLTIKDLHVEIEGKEILKGVNLEIKGGEFHAVMGPNGTGK STLSAAIMGHPKYEVTKGSITLDGKDVLEMEVDERAQAGLFLAMQYPSEISGVTNADF LRSAINARREEGDEISLMKFIRKMDENMEFLEMDPEMAQRYLNEGFSGGEKKRNEILQ LMMIEPKIAILDEIDSGLDIDALKVVSKGINKMRSENFGCLMITHYQRLLNYITPDVV HVMMQGRVVKSGGAELAQRLEAEGYDWIKQELGIEDETVGQEA*" /label="sufC CDS" gene complement(3011109..3011894) /gene="sufC" /locus_tag="BSU_32710" /old_locus_tag="BSU32710" /label="sufC gene" promotor_-10 complement(3011938..3011957) /Source="Nicolas_upshift_promotors" /id="U2564" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.658341658341658" /psig=1 /xcortree=2086 /SigmaFactorBS="gaatgtgcaaggcacgataaaAAGTTGTAtttacttttcatt TGTTATAAAATTAGAATGAGaataaaatgagaataatgattatatatttttggaggta t" /listShort="sufC, sufD, sufS, iscU, sufB, S1257" /listLong="yuzN, S1256, yurT, S1255, yurR, yurQ" /label="promotor_-10" upshifts complement(3011939) /Source="Nicolas_upshifts" /id="U2564" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.658341658341658" /psig=1 /xcortree=2086 /SigmaFactorBS="gaatgtgcaaggcacgataaaAAGTTGTAtttacttttcatt TGTTATAAAATTAGAATGAGaataaaatgagaataatgattatatatttttggaggta t" /listShort="sufC, sufD, sufS, iscU, sufB, S1257" /listLong="yuzN, S1256, yurT, S1255, yurR, yurQ" /label="upshifts" promotor_-35 complement(3011971..3011978) /Source="Nicolas_upshift_promotors" /id="U2564" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.658341658341658" /psig=1 /xcortree=2086 /SigmaFactorBS="gaatgtgcaaggcacgataaaAAGTTGTAtttacttttcatt TGTTATAAAATTAGAATGAGaataaaatgagaataatgattatatatttttggaggta t" /listShort="sufC, sufD, sufS, iscU, sufB, S1257" /listLong="yuzN, S1256, yurT, S1255, yurR, yurQ" /label="promotor_-35" promotor_-10 complement(3011995..3012014) /Source="Nicolas_upshift_promotors" /id="U2565" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.829170829170829" /psig=1 /xcortree=2486 /SigmaFactorBS="gtgggaatccactctttttctttttcaatcGCTTTaataaag tgctgatcTTTGTTAAACTTGAGGAATGtgcaaggcacgataaaaagttgtatttact t" /listShort="sufC, sufD, sufS, iscU, sufB, S1257" /listLong="yuzN, S1256, yurT, S1255, yurR, yurQ" /label="promotor_-10" upshifts complement(3012004) /Source="Nicolas_upshifts" /id="U2565" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.829170829170829" /psig=1 /xcortree=2486 /SigmaFactorBS="gtgggaatccactctttttctttttcaatcGCTTTaataaag tgctgatcTTTGTTAAACTTGAGGAATGtgcaaggcacgataaaaagttgtatttact t" /listShort="sufC, sufD, sufS, iscU, sufB, S1257" /listLong="yuzN, S1256, yurT, S1255, yurR, yurQ" /label="upshifts" S_feature complement(3012006..3012087) /Source="Nicolas_S_feature" /locus_tag="new_3360892_3360973_c" /HighExp="Salt, HiOs, B60, LoTm, T1.0H, Gly, T2.0H, C30, Etha, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF" /TUshortPSig="0.994, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1258" promotor_-35 complement(3012030..3012034) /Source="Nicolas_upshift_promotors" /id="U2565" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.829170829170829" /psig=1 /xcortree=2486 /SigmaFactorBS="gtgggaatccactctttttctttttcaatcGCTTTaataaag tgctgatcTTTGTTAAACTTGAGGAATGtgcaaggcacgataaaaagttgtatttact t" /listShort="sufC, sufD, sufS, iscU, sufB, S1257" /listLong="yuzN, S1256, yurT, S1255, yurR, yurQ" /label="promotor_-35" misc_RNA complement(3012051..3012298) /gene="bsrI" /locus_tag="BSU_misc_RNA_84" /product="small regulatory RNA or messenger RNA" /experiment="publication(s) with functional evidences, PMID:18948176" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18948176; Product type n: RNA" /label="bsrI RNA" gene complement(3012051..3012298) /gene="bsrI" /locus_tag="BSU_misc_RNA_84" /label="bsrI gene" CDS complement(3012088..3012225) /gene="yuzK" /locus_tag="BSU_32719" /old_locus_tag="BSU32719" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative toxin of a toxin antitoxin system" /protein_id="YP_003097782.1" /db_xref="EnsemblGenomes-Gn:BSU32719" /db_xref="EnsemblGenomes-Tr:CAX52688" /db_xref="UniProtKB/Swiss-Prot:C0H3Q9" /translation="MEKAMQLSHGIGYEEYGRRLETRMKVERQRELDYEKSKRISAGA Y*" /label="yuzK CDS" gene complement(3012088..3012225) /gene="yuzK" /locus_tag="BSU_32719" /old_locus_tag="BSU32719" /label="yuzK gene" S_feature complement(3012226..3012310) /Source="Nicolas_S_feature" /locus_tag="new_3361112_3361196_c" /HighExp="HiOs, Salt, B60, S5, T1.0H, S8, HiTm, S7, T1.30H, Etha" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.63415999999999995" /TUshortSig="SigA, SigGF" /TUshortPSig="0.994, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1259" promotor_-10 complement(3012294..3012313) /Source="Nicolas_upshift_promotors" /id="U2566" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.437562437562438" /psig="0.994005994005994" /xcortree=2864 /SigmaFactorBS="tttcgtctcatctgccgctatttcacgccaaatcgtttTTGC ggcatccaacgcagcACTGGTACAATAAAAAGCAAatatatgaagggattgattcatt a" /listShort="S1259, yuzK, S1258, sufC, sufD, sufS, iscU, sufB, S1257" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3012310) /Source="Nicolas_upshifts" /id="U2566" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.437562437562438" /psig="0.994005994005994" /xcortree=2864 /SigmaFactorBS="tttcgtctcatctgccgctatttcacgccaaatcgtttTTGC ggcatccaacgcagcACTGGTACAATAAAAAGCAAatatatgaagggattgattcatt a" /listShort="S1259, yuzK, S1258, sufC, sufD, sufS, iscU, sufB, S1257" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3012312..3012418) /Source="Nicolas_S_feature" /locus_tag="new_3361198_3361304_c" /HighExp="S8, S5, S7, S6, S4, BT, ferm, nit, S3, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1260" promotor_-35 complement(3012329..3012332) /Source="Nicolas_upshift_promotors" /id="U2566" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.437562437562438" /psig="0.994005994005994" /xcortree=2864 /SigmaFactorBS="tttcgtctcatctgccgctatttcacgccaaatcgtttTTGC ggcatccaacgcagcACTGGTACAATAAAAAGCAAatatatgaagggattgattcatt a" /listShort="S1259, yuzK, S1258, sufC, sufD, sufS, iscU, sufB, S1257" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3012419..3012796) /gene="yurZ" /locus_tag="BSU_32720" /old_locus_tag="BSU32720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391151.1" /db_xref="EnsemblGenomes-Gn:BSU32720" /db_xref="EnsemblGenomes-Tr:CAB15261" /db_xref="GOA:O32166" /db_xref="InterPro:IPR003779" /db_xref="InterPro:IPR029032" /db_xref="SubtiList:BG14012" /db_xref="UniProtKB/Swiss-Prot:O32166" /translation="MEGFSLNQDRGSMQDALKQYKHGLGTFEQKMPLMGRKFNEFTEQ CFAGNSLTEREKQLIALGIAINAQDEYCMIYHTKGCLDQGASEENILEAVSVAAAFGG GAAFSQGVTVVQQCIEEFGNTTH*" /label="yurZ CDS" gene complement(3012419..3012796) /gene="yurZ" /locus_tag="BSU_32720" /old_locus_tag="BSU32720" /label="yurZ gene" promotor_-10 complement(3012813..3012824) /Source="Nicolas_upshift_promotors" /id="U2567" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=935 /SigmaFactorBS="actgaaaccccggatgagaattccggggtttttttCGCGTAT tttcctaaaagctGTTCATAATAAAaaggaatgttaaacagatggagggattttcttt g" /listShort="yurZ, S1260, S1259, yuzK, S1258" /listLong="sufC, sufD, sufS, iscU, sufB, S1257" /label="promotor_-10" upshifts complement(3012819) /Source="Nicolas_upshifts" /id="U2567" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=935 /SigmaFactorBS="actgaaaccccggatgagaattccggggtttttttCGCGTAT tttcctaaaagctGTTCATAATAAAaaggaatgttaaacagatggagggattttcttt g" /listShort="yurZ, S1260, S1259, yuzK, S1258" /listLong="sufC, sufD, sufS, iscU, sufB, S1257" /label="upshifts" promotor_-35 complement(3012838..3012844) /Source="Nicolas_upshift_promotors" /id="U2567" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=935 /SigmaFactorBS="actgaaaccccggatgagaattccggggtttttttCGCGTAT tttcctaaaagctGTTCATAATAAAaaggaatgttaaacagatggagggattttcttt g" /listShort="yurZ, S1260, S1259, yuzK, S1258" /listLong="sufC, sufD, sufS, iscU, sufB, S1257" /label="promotor_-35" CDS complement(3012881..3013705) /gene="metQ" /locus_tag="BSU_32730" /old_locus_tag="BSU32730" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10094622, 12910260, 14990259, 16109943, 17038623" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12910260, 14990259, 16109943, 17038623; Product type t : transporter" /codon_start=1 /transl_table=11 /product="methionine ABC transporter, substrate binding lipoprotein" /protein_id="NP_391152.1" /db_xref="EnsemblGenomes-Gn:BSU32730" /db_xref="EnsemblGenomes-Tr:CAB15262" /db_xref="GOA:O32167" /db_xref="InterPro:IPR004872" /db_xref="PDB:4GOT" /db_xref="SubtiList:BG14013" /db_xref="UniProtKB/Swiss-Prot:O32167" /translation="MKKLFLGALLLVFAGVMAACGSNNGAESGKKEIVVAATKTPHAE ILKEAEPLLKEKGYTLKVKVLSDYKMYNKALADKEVDANYFQHIPYLEQEMKENTDYK LVNAGAVHLEPFGIYSKTYKSLKDLPDGATIILTNNVAEQGRMLAMLENAGLITLDSK VETVDATLKDIKKNPKNLEFKKVAPELTAKAYENKEGDAVFINVNYAIQNKLNPKKDA IEVESTKNNPYANIIAVRKGEEDSAKIKALMEVLHSKKIKDFIEKKYDGAVLPVSE*" /label="metQ CDS" gene complement(3012881..3013705) /gene="metQ" /locus_tag="BSU_32730" /old_locus_tag="BSU32730" /label="metQ gene" downshifts complement(3012889) /Source="Nicolas_upshifts" /id="D1694" /incds=0 /nref=167 /ntot=246 /MaxReadThrough="2.13581" /MaxDrop="6.33517" /score="28.8468637" /energy="-12.6" /TU="NA" /idTUdmin="U2569" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" downshifts complement(3013038) /Source="Nicolas_upshifts" /id="D1695" /incds=1 /nref=2 /ntot=171 /MaxReadThrough="6.93658" /MaxDrop="2.3341" /score="28.8468637" /energy="-12.6" /TU="U2569" /idTUdmin="U2569" /TUdmin="-154" /isTUend="FALSE" /label="downshifts" promotor_-35 3013065..3013070 /Source="Nicolas_upshift_promotors" /id="U2568" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1218 /SigmaFactorBS="gtttttcgttgattctacttcaattgcgtcttttttaGGATT TaatttattttggatcGCATAGTTTACATTGATGAagaccgcgtctccttctttgttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3013086..3013104 /Source="Nicolas_upshift_promotors" /id="U2568" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1218 /SigmaFactorBS="gtttttcgttgattctacttcaattgcgtcttttttaGGATT TaatttattttggatcGCATAGTTTACATTGATGAagaccgcgtctccttctttgttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3013088 /Source="Nicolas_upshifts" /id="U2568" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1218 /SigmaFactorBS="gtttttcgttgattctacttcaattgcgtcttttttaGGATT TaatttattttggatcGCATAGTTTACATTGATGAagaccgcgtctccttctttgttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3013719..3014387) /gene="metP" /locus_tag="BSU_32740" /old_locus_tag="BSU32740" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10094622, 12910260, 14990259, 15849754, 16850406, 17038623" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12910260, 14990259, 15849754, 16850406, 17038623; Product type t : transporter" /codon_start=1 /transl_table=11 /product="methionine ABC transporter, permease component" /protein_id="NP_391153.1" /db_xref="EnsemblGenomes-Gn:BSU32740" /db_xref="EnsemblGenomes-Tr:CAB15263" /db_xref="GOA:O32168" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG14014" /db_xref="UniProtKB/Swiss-Prot:O32168" /translation="MFEKYFPNVDLTELWNATYETLYMTLISLLFAFVIGVILGLLLF LTSKGSLWQNKAVNSVIAAVVNIFRSIPFLILIILLLGFTKFLVGTILGPNAALPALV IGSAPFYARLVEIALREVDKGVIEAAKSMGAKTSTIIFKVLIPESMPALISGITVTAI ALIGSTAIAGAIGSGGLGNLAYVEGYQSNNADVTFVATVFILIIVFIIQIIGDLITNI IDKR*" /label="metP CDS" gene complement(3013719..3014387) /gene="metP" /locus_tag="BSU_32740" /old_locus_tag="BSU32740" /label="metP gene" CDS complement(3014380..3015405) /gene="metN" /locus_tag="BSU_32750" /old_locus_tag="BSU32750" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10094622, 12910260, 14990259, 17038623" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12910260, 14990259, 17038623; Product type t: transporter" /codon_start=1 /transl_table=11 /product="methionine ABC transporter (ATP-binding protein)" /protein_id="NP_391154.1" /db_xref="EnsemblGenomes-Gn:BSU32750" /db_xref="EnsemblGenomes-Tr:CAB15264" /db_xref="GOA:O32169" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR017908" /db_xref="InterPro:IPR018449" /db_xref="InterPro:IPR026253" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG14015" /db_xref="UniProtKB/Swiss-Prot:O32169" /translation="MINLQDVSKVYKSKHGDVNAVQNVSLSIKKGEIFGIIGYSGAGK SSLIRLLNGLEKPTSGTVEVAGTKINEVNGRGLRKARHEISMIFQHFNLLWSRTVRDN IMFPLEIAGVKKSERIKRANELIKLVGLEGKEKSYPSQLSGGQKQRVGIARALANNPK VLLCDEATSALDPQTTDSILDLLSDINERLGLTIVLITHEMHVIRKICNRVAVMENGK VVEEGEVLDVFKNPKEQMTKRFVQQVTEPEETKETLQHLLDDTASGKMVQLTFVGESA EQPLITEMIRNFNVSVNILQGKISQTKDGAYGSLFIHIDGDEEEVQNVIRFINDKQVK AEVITNV*" /label="metN CDS" gene complement(3014380..3015405) /gene="metN" /locus_tag="BSU_32750" /old_locus_tag="BSU32750" /label="metN gene" S_feature complement(3015406..3015510) /Source="Nicolas_S_feature" /locus_tag="new_3364292_3364396_c" /HighExp="MG 5, MG t5, MG 10, BMM, MG-0.2, GM 25, MG-0.1, MG 15, M9-exp, MG 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.996" /TUlongSig="SigA" /TUlongPSig="0.999" /label="S1261" misc_RNA complement(3015511..3015617) /gene="mswH" /locus_tag="BSU_misc_RNA_53" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762; Product type n: RNA" /function="16.3: Control" /label="mswH RNA" gene complement(3015511..3015617) /gene="mswH" /locus_tag="BSU_misc_RNA_53" /label="mswH gene" downshifts 3015580 /Source="Nicolas_upshifts" /id="D1696" /incds=0 /nref=2 /ntot=37 /MaxReadThrough="1.54417" /MaxDrop="5.51028" /score="-1.70178746" /energy="-11.2" /TU="NA" /idTUdmin="U2568" /TUdmin=2420 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3015644..3015663) /Source="Nicolas_upshift_promotors" /id="U2569" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2424 /SigmaFactorBS="tataatagtaaaagttgacatcatttatttTATTGACAttta atcattcgccgTGCTATTCTACATTAAGAATttccggacgaaaaagactatatatttc t" /listShort="NA, S1261, metQ, metP, metN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3015656) /Source="Nicolas_upshifts" /id="U2569" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2424 /SigmaFactorBS="tataatagtaaaagttgacatcatttatttTATTGACAttta atcattcgccgTGCTATTCTACATTAAGAATttccggacgaaaaagactatatatttc t" /listShort="NA, S1261, metQ, metP, metN" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3015658..3015731) /Source="Nicolas_S_feature" /locus_tag="new_3364544_3364617_c" /HighExp="M9-stat, S2, LoTm, T5.0H, HiOs, B60, S3, T3.30H, LPhT, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.996, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1262" promotor_-35 complement(3015679..3015686) /Source="Nicolas_upshift_promotors" /id="U2569" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2424 /SigmaFactorBS="tataatagtaaaagttgacatcatttatttTATTGACAttta atcattcgccgTGCTATTCTACATTAAGAATttccggacgaaaaagactatatatttc t" /listShort="NA, S1261, metQ, metP, metN" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3015732..3016076) /gene="yusD" /locus_tag="BSU_32760" /old_locus_tag="BSU32760" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391155.1" /db_xref="EnsemblGenomes-Gn:BSU32760" /db_xref="EnsemblGenomes-Tr:CAB15265" /db_xref="InterPro:IPR003033" /db_xref="InterPro:IPR036527" /db_xref="SubtiList:BG14016" /db_xref="UniProtKB/Swiss-Prot:O32170" /translation="MEKAEVLEDEYQHLFLKPLLNASTLLITFQGEAEALTVSINEQG EMKKVSPPQTSNLTFYGNQTEIIDLLHGDISLQHLIQSGSLKVKGSFRALLKLEAILW LTNGFFQRILKN*" /label="yusD CDS" gene complement(3015732..3016076) /gene="yusD" /locus_tag="BSU_32760" /old_locus_tag="BSU32760" /label="yusD gene" S_feature complement(3016077..3016182) /Source="Nicolas_S_feature" /locus_tag="new_3364963_3365068_c" /HighExp="LPhT, HiOs, M9-stat, dia5, T2.0H, Diami, T1.30H, T0.30H, T2.30H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigGF, SigA, SigA" /TUshortPSig="1, 0.996, 0.999" /TUlongSig="SigA" /TUlongPSig=1 /label="S1263" CDS complement(3016183..3016503) /gene="yusE" /locus_tag="BSU_32770" /old_locus_tag="BSU32770" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15937154, 25875741; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative thiol-disulfide oxidoreductase with thioredoxin domain" /protein_id="NP_391156.1" /db_xref="EnsemblGenomes-Gn:BSU32770" /db_xref="EnsemblGenomes-Tr:CAB15266" /db_xref="GOA:O32171" /db_xref="InterPro:IPR005746" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG14017" /db_xref="UniProtKB/Swiss-Prot:O32171" /translation="MKELQEHELDHIEDDVYLLYLYTPFCGTCQLASKMLTVVKEMLP DVAFYQNNVNYSPTFAKAYQIESVPCFLLFKGGKMVERGYAFHSVSYLYELIKQKSSS ASHL*" /label="yusE CDS" gene complement(3016183..3016503) /gene="yusE" /locus_tag="BSU_32770" /old_locus_tag="BSU32770" /label="yusE gene" CDS complement(3016505..3016945) /gene="yusF" /locus_tag="BSU_32780" /old_locus_tag="BSU32780" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12794188; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ribonuclease" /protein_id="NP_391157.1" /db_xref="EnsemblGenomes-Gn:BSU32780" /db_xref="EnsemblGenomes-Tr:CAB15267" /db_xref="GOA:O32172" /db_xref="InterPro:IPR006171" /db_xref="InterPro:IPR034141" /db_xref="SubtiList:BG14018" /db_xref="UniProtKB/Swiss-Prot:O32172" /translation="MLAVNFTAFFYNLNISNLTRQVNKMKMDELEKVMIVEGKSDKEK IESVLNEPMRIICTNGTISQLRLEELADELYDKDVYILVDADESGEKLRKQLKREFNE ACHLHVDRAYKEVAAAPRHHIASVLLRANLNVHTIFLERKSRGV*" /label="yusF CDS" gene complement(3016505..3016945) /gene="yusF" /locus_tag="BSU_32780" /old_locus_tag="BSU32780" /label="yusF gene" CDS complement(3016945..3017181) /gene="yusG" /locus_tag="BSU_32790" /old_locus_tag="BSU32790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391158.1" /db_xref="EnsemblGenomes-Gn:BSU32790" /db_xref="EnsemblGenomes-Tr:CAB15268" /db_xref="InterPro:IPR020140" /db_xref="SubtiList:BG14019" /db_xref="UniProtKB/Swiss-Prot:O32173" /translation="MAFDKQKLDVTNDVTGRFQNGRLSLYHDNEMIGQMTSMNEYELK SGYSFENEKFYKTADVVSGDDAKYVDCDYENGWC*" /label="yusG CDS" gene complement(3016945..3017181) /gene="yusG" /locus_tag="BSU_32790" /old_locus_tag="BSU32790" /label="yusG gene" downshifts complement(3016957) /Source="Nicolas_upshifts" /id="D1697" /incds=0 /nref=35 /ntot=245 /MaxReadThrough="6.00162" /MaxDrop="3.9147" /score="-1.53913693" /energy="-11" /TU="U2570,U2571,U2572" /idTUdmin="U2574" /TUdmin=723 /isTUend="FALSE" /label="downshifts" upshifts complement(3017196) /Source="Nicolas_upshifts" /id="U2570" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=805 /SigmaFactorBS="agatgacacaagaagactaaaacAGGATAGccgtaaaagcaa ttGGACACGCTAACgttatgggaggtgtccaatatggctttcgacaaacaaaagctcg a" /listShort="yusG, yusF, yusE, S1263, yusD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3017201..3017212) /Source="Nicolas_upshift_promotors" /id="U2570" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=805 /SigmaFactorBS="agatgacacaagaagactaaaacAGGATAGccgtaaaagcaa ttGGACACGCTAACgttatgggaggtgtccaatatggctttcgacaaacaaaagctcg a" /listShort="yusG, yusF, yusE, S1263, yusD" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3017227..3017233) /Source="Nicolas_upshift_promotors" /id="U2570" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=805 /SigmaFactorBS="agatgacacaagaagactaaaacAGGATAGccgtaaaagcaa ttGGACACGCTAACgttatgggaggtgtccaatatggctttcgacaaacaaaagctcg a" /listShort="yusG, yusF, yusE, S1263, yusD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3017237..3017620) /gene="gcvH" /locus_tag="BSU_32800" /old_locus_tag="BSU32800" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 20882995, 21338421; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycine cleavage system protein H (lipoyl acceptor protein)" /protein_id="NP_391159.1" /db_xref="EnsemblGenomes-Gn:BSU32800" /db_xref="EnsemblGenomes-Tr:CAB15269" /db_xref="GOA:O32174" /db_xref="InterPro:IPR000089" /db_xref="InterPro:IPR002930" /db_xref="InterPro:IPR003016" /db_xref="InterPro:IPR011053" /db_xref="InterPro:IPR017453" /db_xref="InterPro:IPR033753" /db_xref="SubtiList:BG14020" /db_xref="UniProtKB/Swiss-Prot:O32174" /translation="MSIPKDLRYSGEHEWVKVEGEKARIGITHFAQSELGDIVFVELP EVGAEIKADEPFGSVESVKTVSELYAPINGTVVEVNEDLDDSPEFVNESPYEKAWMIV VEPSDASEIEKLMTAEQYEEMTQED*" /label="gcvH CDS" gene complement(3017237..3017620) /gene="gcvH" /locus_tag="BSU_32800" /old_locus_tag="BSU32800" /label="gcvH gene" promotor_-10 complement(3017647..3017666) /Source="Nicolas_upshift_promotors" /id="U2571" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.601398601398601" /psig="0.996003996003996" /xcortree=2237 /SigmaFactorBS="aagaagaccaatttgaagaaaactgggcttaaTGTAAATTtt ttttgaaaagTGTGGTATCTTCTTATTGTAgtgctgtaaaaaatggagggattcaatt g" /listShort="yusH, yusG, yusF, yusE, S1263, yusD, S1262, NA, S1261, metQ" /listLong="metP, metN" /label="promotor_-10" upshifts complement(3017658) /Source="Nicolas_upshifts" /id="U2571" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.601398601398601" /psig="0.996003996003996" /xcortree=2237 /SigmaFactorBS="aagaagaccaatttgaagaaaactgggcttaaTGTAAATTtt ttttgaaaagTGTGGTATCTTCTTATTGTAgtgctgtaaaaaatggagggattcaatt g" /listShort="yusH, yusG, yusF, yusE, S1263, yusD, S1262, NA, S1261, metQ" /listLong="metP, metN" /label="upshifts" promotor_-35 complement(3017679..3017686) /Source="Nicolas_upshift_promotors" /id="U2571" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.601398601398601" /psig="0.996003996003996" /xcortree=2237 /SigmaFactorBS="aagaagaccaatttgaagaaaactgggcttaaTGTAAATTtt ttttgaaaagTGTGGTATCTTCTTATTGTAgtgctgtaaaaaatggagggattcaatt g" /listShort="yusH, yusG, yusF, yusE, S1263, yusD, S1262, NA, S1261, metQ" /listLong="metP, metN" /label="promotor_-35" CDS complement(3017687..3018043) /gene="yusI" /locus_tag="BSU_32810" /old_locus_tag="BSU32810" /EC_number="1.20.4.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase with thioredoxin domain and regulator domain" /protein_id="NP_391160.1" /db_xref="EnsemblGenomes-Gn:BSU32810" /db_xref="EnsemblGenomes-Tr:CAB15270" /db_xref="GOA:O32175" /db_xref="InterPro:IPR006504" /db_xref="InterPro:IPR006660" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG14021" /db_xref="UniProtKB/Swiss-Prot:O32175" /translation="MSLTFYWYPKCGTCRKAKKWLEEHGKEINEIHIAEQPPSKEELK ALYEKSGLDLKKFFNTSGMKYRELNLKEKLYHMSEDEQLELLASDGMLIKRPLTTDGE KVTVGFKEDQFEENWA*" /label="yusI CDS" gene complement(3017687..3018043) /gene="yusI" /locus_tag="BSU_32810" /old_locus_tag="BSU32810" /label="yusI gene" promotor_-10 complement(3018066..3018085) /Source="Nicolas_upshift_promotors" /id="U2572" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.562437562437562" /psig="0.999000999001" /xcortree=2011 /SigmaFactorBS="atgcgcggagctcttttttaagaagcactgttTTAGGTtttt aaaacaaacTGTGTTAAAATAACCTCGATtattttattgagggggaagaagatgtcgt t" /listShort="yusI, yusH, yusG, yusF, yusE, S1263, yusD, S1262" /listLong="NA, S1261, metQ, metP, metN" /label="promotor_-10" upshifts complement(3018076) /Source="Nicolas_upshifts" /id="U2572" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.562437562437562" /psig="0.999000999001" /xcortree=2011 /SigmaFactorBS="atgcgcggagctcttttttaagaagcactgttTTAGGTtttt aaaacaaacTGTGTTAAAATAACCTCGATtattttattgagggggaagaagatgtcgt t" /listShort="yusI, yusH, yusG, yusF, yusE, S1263, yusD, S1262" /listLong="NA, S1261, metQ, metP, metN" /label="upshifts" promotor_-35 complement(3018099..3018104) /Source="Nicolas_upshift_promotors" /id="U2572" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.562437562437562" /psig="0.999000999001" /xcortree=2011 /SigmaFactorBS="atgcgcggagctcttttttaagaagcactgttTTAGGTtttt aaaacaaacTGTGTTAAAATAACCTCGATtattttattgagggggaagaagatgtcgt t" /listShort="yusI, yusH, yusG, yusF, yusE, S1263, yusD, S1262" /listLong="NA, S1261, metQ, metP, metN" /label="promotor_-35" CDS complement(3018154..3019938) /gene="fadE" /locus_tag="BSU_32820" /old_locus_tag="BSU32820" /EC_number="1.3.99.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17189250, 21398533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17189250, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acyl-CoA dehydrogenase (FAD dependent)" /protein_id="NP_391161.1" /db_xref="EnsemblGenomes-Gn:BSU32820" /db_xref="EnsemblGenomes-Tr:CAB15271" /db_xref="GOA:O32176" /db_xref="InterPro:IPR006089" /db_xref="InterPro:IPR006091" /db_xref="InterPro:IPR009075" /db_xref="InterPro:IPR009100" /db_xref="InterPro:IPR013786" /db_xref="InterPro:IPR036250" /db_xref="InterPro:IPR037069" /db_xref="SubtiList:BG14022" /db_xref="UniProtKB/Swiss-Prot:O32176" /translation="MAKKAADVQKGGGFLIEDVTYDQMYTPEDFTDEHKMIAKTTEDY IEQDVLPHIDDIENHQFEHSVRLLKKAGELGLLGADVPEEYGGLGLDKISSALITEKF SRAGSFSLSYGAHVGIGSLPIVFFGSEEQKKKYLPGLASGEKIAAYALTEPGSGSDAL GAKTTAVLNEAGTHYVLTGEKQWITNSAFADVFVVYAKVDGDKFSAFIVEKEFPGVST GPEEKKMGIKGSSTRTLILDQAEVPKENLLGEIGKGHVIAFNILNIGRYKLAVGTIGA SKRVIELSAAYANQRRQFKTPIAGFSLTQEKIGTMASRLYAMESSVYRTVGLFEDNMS QFTAEDLKDGRQIAKSIAEYAIECSLNKVFGSETLDYIVDEGVQIHGGYGFMQEYEVE RAYRDSRINRIFEGTNEINRLIVPSTFLKKALKGELPLFEKAQSLQEELMMLMPEEPG SGVLEQEKYIVKQAKKIALFAAGLAAQKYGKAIDREQEILVNVADIVSNVYAMESAVL RTEKAIAAQGAEKAAQKVLYTEIFVQEAFNEIEAHAKESLIAMEEGDSLRMMLSALRK LTRVTPKNVIQKKREAAAGIFEAEKYTV*" /label="fadE CDS" gene complement(3018154..3019938) /gene="fadE" /locus_tag="BSU_32820" /old_locus_tag="BSU32820" /label="fadE gene" downshifts complement(3018164) /Source="Nicolas_upshifts" /id="D1698" /incds=0 /nref=24 /ntot=46 /MaxReadThrough="4.78872" /MaxDrop="6.88218" /score="31.8022607" /energy="-16.4" /TU="U2574" /idTUdmin="U2576" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3019953..3021128) /gene="fadA" /locus_tag="BSU_32830" /old_locus_tag="BSU32830" /EC_number="2.3.1.16" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17189250, 21398533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17189250, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetyl-CoA C-acyltransferase" /protein_id="NP_391162.1" /db_xref="EnsemblGenomes-Gn:BSU32830" /db_xref="EnsemblGenomes-Tr:CAB15272" /db_xref="GOA:O32177" /db_xref="InterPro:IPR002155" /db_xref="InterPro:IPR016039" /db_xref="InterPro:IPR020610" /db_xref="InterPro:IPR020613" /db_xref="InterPro:IPR020615" /db_xref="InterPro:IPR020616" /db_xref="InterPro:IPR020617" /db_xref="SubtiList:BG14023" /db_xref="UniProtKB/Swiss-Prot:O32177" /translation="MKEAVIVSGARTPVGKAKKGSLATVRPDDLGAICVKETLKRAGG YEGNIDDLIIGCATPEAEQGLNMARNIGALAGLPYTVPAITVNRYCSSGLQSIAYAAE KIMLGAYDTAIAGGAESMSQVPMMGHVTRPNLALAEKAPEYYMSMGHTAEQVAKKYGV SREDQDAFAVRSHQNAAKALAEGKFKDEIVPVEVTVTEIGEDHKPMEKQFVFSQDEGV RPQTTADILSTLRPAFSVDGTVTAGNSSQTSDGAAAVMLMDREKADALGLAPLVKFRS FAVGGVPPEVMGIGPVEAIPRALKLAGLQLQDIGLFELNEAFASQAIQVIRELGIDEE KVNVNGGAIALGHPLGCTGTKLTLSLIHEMKRRNEQFGVVTMCIGGGMGAAGVFELC* " /label="fadA CDS" gene complement(3019953..3021128) /gene="fadA" /locus_tag="BSU_32830" /old_locus_tag="BSU32830" /label="fadA gene" CDS complement(3021139..3023508) /gene="fadN" /locus_tag="BSU_32840" /old_locus_tag="BSU32840" /EC_number="1.1.1.35" /EC_number="4.2.1.17" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 17189250, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase" /protein_id="NP_391163.2" /db_xref="EnsemblGenomes-Gn:BSU32840" /db_xref="EnsemblGenomes-Tr:CAB15273" /db_xref="GOA:O32178" /db_xref="InterPro:IPR001753" /db_xref="InterPro:IPR006108" /db_xref="InterPro:IPR006176" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR029045" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG14024" /db_xref="UniProtKB/Swiss-Prot:O32178" /translation="MHKHIRKAAVLGSGVMGSGIAAHLANIGIPVLLLDIVPNDLTKE EEKKGLTKDSSEVRSRLSRQAMKKLLKQKPAPLTSAKNTSYITPGNLEDDAEKLKEAD WIIEVVVENLEVKKKIFALVDEHRKTGSIVSSNTSGISVQEMAEGRSDDFKAHFLGTH FFNPARYLKLLEIIPIKETDPDILKFMTAFGENVLGKGVVTAKDTPNFIANRIGTYGL LVTVQEMLKGGYQVGEVDSITGPLIGRPKSATFRTLDVVGLDTFAHVARNVYDKADGD EKEVFRIPSFMNDMLEKGWIGSKAGQGFYKKEGKTIYELDPVTLTYGERTKMKSPALE AAKQAKGTKAKMKALIYSDDRAGRLLWNITSQTLLYSAELLGEIADDIHAIDQAMKWG FGWELGPFEMWDAIGLKQSAEKLEQLGADMPGWIKEMLDKGNETFYIKENGTVFYYDR GEYRAVKENKKRIHLQALKETKGVIAKNSGASLIDLGDDVALLEFHSKSNAIGLDIIQ MIHKGLEETERNYKGLVIGNQGKNFCVGANLAMILMEVQDDNFLEVDFVIRRFQETMM KIKYSAKPVVAAPFGMTLGGGTEACLPAARIQAASEAYMGLVESGVGLIPGGGGNKEL YINHLRRGHDPMNAAMKTFETIAMAKVSASAQEAREMNILKETDQISVNQDHLLYDAK QLAASLYDTGWRPPVKEKVKVPGETGYAALLLGAEQMKLSGYISEHDFKIAKKLAYVI AGGKVPFGTEVDEEYLLEIEREAFLSLSGEAKSQARMQHMLVKGKPLRN*" /label="fadN CDS" gene complement(3021139..3023508) /gene="fadN" /locus_tag="BSU_32840" /old_locus_tag="BSU32840" /label="fadN gene" promotor_-35 3022927..3022932 /Source="Nicolas_upshift_promotors" /id="U2573" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1035 /SigmaFactorBS="tcggtgtgtcctttgctgtaacaacgcctttcccgagGACAT TttctccgaaagctgTCATAAACTTTAAAATATCaggatccgtttccttaatcggaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3022947..3022965 /Source="Nicolas_upshift_promotors" /id="U2573" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1035 /SigmaFactorBS="tcggtgtgtcctttgctgtaacaacgcctttcccgagGACAT TttctccgaaagctgTCATAAACTTTAAAATATCaggatccgtttccttaatcggaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3022950 /Source="Nicolas_upshifts" /id="U2573" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1035 /SigmaFactorBS="tcggtgtgtcctttgctgtaacaacgcctttcccgagGACAT TttctccgaaagctgTCATAAACTTTAAAATATCaggatccgtttccttaatcggaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3023576..3023595) /Source="Nicolas_upshift_promotors" /id="U2574" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.622377622377622" /psig=1 /xcortree=375 /SigmaFactorBS="catacaaaaaaataacaaattagCTATTGAAgtcgaaccgga aaTCTTTTAAGATGAAAGAAGAaacgggtttcattttttttagtcaaaaaatgaatga c" /listShort="fadN, fadA, fadE, yusI" /listLong="yusH, yusG, yusF, yusE, S1263, yusD" /label="promotor_-10" upshifts complement(3023579) /Source="Nicolas_upshifts" /id="U2574" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.622377622377622" /psig=1 /xcortree=375 /SigmaFactorBS="catacaaaaaaataacaaattagCTATTGAAgtcgaaccgga aaTCTTTTAAGATGAAAGAAGAaacgggtttcattttttttagtcaaaaaatgaatga c" /listShort="fadN, fadA, fadE, yusI" /listLong="yusH, yusG, yusF, yusE, S1263, yusD" /label="upshifts" S_feature complement(3023587..3023853) /Source="Nicolas_S_feature" /locus_tag="new_3372473_3372739_c" /HighExp="S8, S6, S7, BT, B36, G/S, B60, S5, Pyr, S3" /AntisenseName="yuzL" /AntisenseCor="0.77564732124057401" /AntisenseRegPval="-54.6" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S1264" promotor_-35 complement(3023609..3023616) /Source="Nicolas_upshift_promotors" /id="U2574" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.622377622377622" /psig=1 /xcortree=375 /SigmaFactorBS="catacaaaaaaataacaaattagCTATTGAAgtcgaaccgga aaTCTTTTAAGATGAAAGAAGAaacgggtttcattttttttagtcaaaaaatgaatga c" /listShort="fadN, fadA, fadE, yusI" /listLong="yusH, yusG, yusF, yusE, S1263, yusD" /label="promotor_-35" promotor_-35 3023634..3023640 /Source="Nicolas_upshift_promotors" /id="U2575" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=890 /SigmaFactorBS="ctaatttgttattttttTGTATGAagcctataaaagtcGGGC AACTTAAGcccggaggtgaagggaatggtacgagagaaaaaaaatccgtcttcagcgg c" /listShort="yuzL, S1265, yuzM, yusN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3023655..3023666 /Source="Nicolas_upshift_promotors" /id="U2575" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=890 /SigmaFactorBS="ctaatttgttattttttTGTATGAagcctataaaagtcGGGC AACTTAAGcccggaggtgaagggaatggtacgagagaaaaaaaatccgtcttcagcgg c" /listShort="yuzL, S1265, yuzM, yusN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3023677 /Source="Nicolas_upshifts" /id="U2575" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=890 /SigmaFactorBS="ctaatttgttattttttTGTATGAagcctataaaagtcGGGC AACTTAAGcccggaggtgaagggaatggtacgagagaaaaaaaatccgtcttcagcgg c" /listShort="yuzL, S1265, yuzM, yusN" /GFF_Attribute="listLong" /label="upshifts" CDS 3023683..3023829 /gene="yuzL" /locus_tag="BSU_32849" /old_locus_tag="BSU32849" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 17189250" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097783.1" /db_xref="EnsemblGenomes-Gn:BSU32849" /db_xref="EnsemblGenomes-Tr:CAX52689" /db_xref="InterPro:IPR025625" /db_xref="UniProtKB/Swiss-Prot:C0H3R0" /translation="MVREKKNPSSAAVSAASVKGDAGPTQHYGGGKRTSQNQQYKKHN MGQS*" /label="yuzL CDS" gene 3023683..3023829 /gene="yuzL" /locus_tag="BSU_32849" /old_locus_tag="BSU32849" /label="yuzL gene" S_feature 3023830..3024856 /Source="Nicolas_S_feature" /locus_tag="new_3372716_3373742" /HighExp="S8, S5, S7, S4, S6, nit, ferm, T5.0H, S3, LoTm" /AntisenseName="fadM" /AntisenseCor="0.80952501049450498" /AntisenseRegPval="-63" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1265" CDS complement(3023854..3024762) /gene="putM" /locus_tag="BSU_32850" /old_locus_tag="BSU32850" /EC_number="1.5.5.2" /function="3.2: Degradation" /experiment="publication(s) with functional evidences, PMID:17189250, 17536821, 21398533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17189250, 17536821, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="proline dehydrogenase 1" /protein_id="NP_391164.1" /db_xref="EnsemblGenomes-Gn:BSU32850" /db_xref="EnsemblGenomes-Tr:CAB15274" /db_xref="GOA:O32179" /db_xref="InterPro:IPR002872" /db_xref="InterPro:IPR008219" /db_xref="InterPro:IPR015659" /db_xref="InterPro:IPR029041" /db_xref="SubtiList:BG14025" /db_xref="UniProtKB/Swiss-Prot:O32179" /translation="MLRHVFLFLSQNKTLTKFAKAYGTRLGARRFVAGDTIESAVKTV KRLNRSGLCATIDYLGEYAASEKEANQVAEECKKAIQAIAEHQLNSELSLKLTSIGLD LSEELALTHLRAILSVAKQYDVAVTIDMEDYSHYEQTLSIYRQCKQEFEKLGTVIQAY LYRAAEDIRKMRDLKPNLRLVKGAYKESAAVAFPDKRGTDLHFQSLIKLQLLSGNYTA VATHDDDIIAFTKQLVAEHQIPASQFEFQMLYGIRPERQKELAKEGYRMRVYVPYGTD WFSYFMRRIAERPANAAFVLKGILKK*" /label="putM CDS" gene complement(3023854..3024762) /gene="putM" /locus_tag="BSU_32850" /old_locus_tag="BSU32850" /label="putM gene" S_feature complement(3024763..3025285) /Source="Nicolas_S_feature" /locus_tag="new_3373649_3374171_c" /HighExp="S8, S6, S7, BT, B36, B60, G/S, Pyr, S5, SMMPr" /AntisenseName="yuzM" /AntisenseCor="0.77827902986544495" /AntisenseRegPval="-55.2" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S1266" CDS 3024857..3025102 /gene="yuzM" /locus_tag="BSU_32859" /old_locus_tag="BSU32859" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097784.1" /db_xref="EnsemblGenomes-Gn:BSU32859" /db_xref="EnsemblGenomes-Tr:CAX52690" /db_xref="InterPro:IPR012347" /db_xref="UniProtKB/Swiss-Prot:C0H3R1" /translation="MDNQQQSQMPPSVISTKDHLYLNDMLNWNLLAMKKAHFMAQQCQ DQTLKQELDRVGHMHHDHYQRILKHLQPGQQQSGYIQ*" /label="yuzM CDS" gene 3024857..3025102 /gene="yuzM" /locus_tag="BSU_32859" /old_locus_tag="BSU32859" /label="yuzM gene" CDS 3025115..3025447 /gene="yusN" /locus_tag="BSU_32860" /old_locus_tag="BSU32860" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative spore coat-like protein" /protein_id="NP_391165.1" /db_xref="EnsemblGenomes-Gn:BSU32860" /db_xref="EnsemblGenomes-Tr:CAB15275" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR012851" /db_xref="SubtiList:BG14026" /db_xref="UniProtKB/Swiss-Prot:O32180" /translation="MNQQNQKISNPQTPVPTTSEMNDRDFVNELLTTEKYMTTAYCTA LHEFSHESLYQDIQSIFDESQKAQRKLYDLMFQYGWYSVEAEDSQKLQQSYQKFQQTI QQQSPYQQ*" /label="yusN CDS" gene 3025115..3025447 /gene="yusN" /locus_tag="BSU_32860" /old_locus_tag="BSU32860" /label="yusN gene" promotor_-10 complement(3025268..3025287) /Source="Nicolas_upshift_promotors" /id="U2576" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1348 /SigmaFactorBS="ttggaacatgagatcatatagttttctttgcgcttTTTGTGA CTCatcaaaaatggatTGAATATCCTGATAAAGAGActcgtggctgaattcgtgcaag g" /listShort="S1266, fadM, S1264, fadN, fadA, fadE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3025285) /Source="Nicolas_upshifts" /id="U2576" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1348 /SigmaFactorBS="ttggaacatgagatcatatagttttctttgcgcttTTTGTGA CTCatcaaaaatggatTGAATATCCTGATAAAGAGActcgtggctgaattcgtgcaag g" /listShort="S1266, fadM, S1264, fadN, fadA, fadE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3025301..3025310) /Source="Nicolas_upshift_promotors" /id="U2576" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1348 /SigmaFactorBS="ttggaacatgagatcatatagttttctttgcgcttTTTGTGA CTCatcaaaaatggatTGAATATCCTGATAAAGAGActcgtggctgaattcgtgcaag g" /listShort="S1266, fadM, S1264, fadN, fadA, fadE" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3025436 /Source="Nicolas_upshifts" /id="D1699" /incds=0 /nref=24 /ntot=46 /MaxReadThrough="2.684" /MaxDrop="5.38418" /score="9.88876972" /energy="-10.2" /TU="NA" /idTUdmin="U2575" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 3025508..3025515 /Source="Nicolas_upshift_promotors" /id="U2577" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.648351648351648" /psig="0.999000999001" /xcortree=2125 /SigmaFactorBS="gggcatctatcctttttttgtgtaaaatCAGTTGACttttca tttacgcTTATTTATATTTAATAAGCAttaactattttgtcattaaaatatatataca g" /listShort="yusO, yusP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3025529..3025548 /Source="Nicolas_upshift_promotors" /id="U2577" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.648351648351648" /psig="0.999000999001" /xcortree=2125 /SigmaFactorBS="gggcatctatcctttttttgtgtaaaatCAGTTGACttttca tttacgcTTATTTATATTTAATAAGCAttaactattttgtcattaaaatatatataca g" /listShort="yusO, yusP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3025540 /Source="Nicolas_upshifts" /id="U2577" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.648351648351648" /psig="0.999000999001" /xcortree=2125 /SigmaFactorBS="gggcatctatcctttttttgtgtaaaatCAGTTGACttttca tttacgcTTATTTATATTTAATAAGCAttaactattttgtcattaaaatatatataca g" /listShort="yusO, yusP" /GFF_Attribute="listLong" /label="upshifts" CDS 3025606..3026073 /gene="mdtR" /locus_tag="BSU_32870" /old_locus_tag="BSU32870" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12923086, 19286808" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12923086, 19286808; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (MarR family, low level antibiotic resistance)" /protein_id="NP_391166.1" /db_xref="EnsemblGenomes-Gn:BSU32870" /db_xref="EnsemblGenomes-Tr:CAB15276" /db_xref="GOA:O32181" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:1S3J" /db_xref="SubtiList:BG14027" /db_xref="UniProtKB/Swiss-Prot:O32181" /translation="MKSADQLMSDIQLSLQALFQKIQPEMLESMEKQGVTPAQLFVLA SLKKHGSLKVSEIAERMEVKPSAVTLMADRLEQKNLIARTHNTKDRRVIDLSLTDEGD IKFEEVLAGRKAIMARYLSFLTEEEMLQAAHITAKLAQAAETDEKQNMKRGNG*" /label="mdtR CDS" gene 3025606..3026073 /gene="mdtR" /locus_tag="BSU_32870" /old_locus_tag="BSU32870" /label="mdtR gene" CDS 3026070..3027695 /gene="mdtP" /locus_tag="BSU_32880" /old_locus_tag="BSU32880" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 19286808" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 19286808; Product type t: transporter" /codon_start=1 /transl_table=11 /product="multidrug-efflux transporter" /protein_id="NP_391167.1" /db_xref="EnsemblGenomes-Gn:BSU32880" /db_xref="EnsemblGenomes-Tr:CAB15277" /db_xref="GOA:O32182" /db_xref="InterPro:IPR004638" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG14028" /db_xref="UniProtKB/Swiss-Prot:O32182" /translation="MKMSKEGKQSKRTLLITGLIIAMFFSALDGTIVGTAMPKIVGDL GGLSMMTWLTTAYLLTSTTIVPIAGKLADLLGRRIVYVSGLIIFMAASALCGMANNMT ELIIFRGLQGIGGGIMMPMAMIVIGDLFTGKQRAKFQGVFGAIYGLASVIGPQIGGWI VDSLNWKWVFYINLPVGIIAVIFIARGLQGRQQTGPINFDIAGIFTMIVGVVSLLLAL SFGGKDYAWDSWQILGLFALALIGIVSFIIVESKAKEPILPMYLFKNRTFTFLNLIGF FMSIGMFGAITFVPFFMQGIVGVSASESGTIMTPMMISMIITSIIGGQLVYKIGIKPQ IITGMLVMAGGFLLLTTLDLDTSKLVATSFMAIIGLGMGLVMPILTLALQESFSKEEL GVVTSSSQFFRSIGGTFGITMLGAVMNARSGNLLTDKLVPYLDSLPAQASSFAAQLKG MIDTNPQGLLQSLFSPDAVKQIPAAFSSHIVPILKTSLMDSLHSVFYTGLIFIAVGAV FTLFLKPIKLSNKKAEDQQEKEKAAKAVESPSH*" /label="mdtP CDS" gene 3026070..3027695 /gene="mdtP" /locus_tag="BSU_32880" /old_locus_tag="BSU32880" /label="mdtP gene" downshifts 3027680 /Source="Nicolas_upshifts" /id="D1700" /incds=0 /nref=217 /ntot=257 /MaxReadThrough="0.3188" /MaxDrop="5.64223" /score="42.0555168" /energy="-17.7" /TU="NA" /idTUdmin="U2577" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3027731..3028114) /gene="yusQ" /locus_tag="BSU_32890" /old_locus_tag="BSU32890" /EC_number="5.3.2.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 25219626; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="hydratase of unidentified specificity (tautomerase superfamily)" /protein_id="NP_391168.1" /db_xref="EnsemblGenomes-Gn:BSU32890" /db_xref="EnsemblGenomes-Tr:CAB15278" /db_xref="GOA:O32183" /db_xref="InterPro:IPR004370" /db_xref="InterPro:IPR014347" /db_xref="SubtiList:BG14029" /db_xref="UniProtKB/Swiss-Prot:O32183" /translation="MPFVQIHLRSGRSEVWLQKLSRTIHQSMIEEINVPEDDYFQVIR QYEKSEFFYDPFYLQVERTDELIYIHFTLKQSRTTEQKKALYRSIASRIHSELGVRKE DVFIMLAGNQDEDWSFGNGRAQMIE*" /label="yusQ CDS" gene complement(3027731..3028114) /gene="yusQ" /locus_tag="BSU_32890" /old_locus_tag="BSU32890" /label="yusQ gene" CDS complement(3028133..3028522) /gene="yusR" /locus_tag="BSU_32900" /old_locus_tag="BSU32900" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15294834; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 3-oxoacyl-acyl-carrier protein reductase" /protein_id="NP_391169.1" /db_xref="EnsemblGenomes-Gn:BSU32900" /db_xref="EnsemblGenomes-Tr:CAB15279" /db_xref="GOA:O32184" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG14030" /db_xref="UniProtKB/Swiss-Prot:O32184" /translation="MKGMFFCARAVVPFMKKSKDGAIVNVGSIAGITGAGSSMPYAVS KSAVHGLTKSLAHALAPEIRVSGVAPGAVATRWWAGREEKMKSMIGSLLLQCIAEPDD VAKLICSLIEQESLTGQIITIDSGQTL*" /label="yusR CDS" gene complement(3028133..3028522) /gene="yusR" /locus_tag="BSU_32900" /old_locus_tag="BSU32900" /label="yusR gene" CDS complement(3028544..3028873) /gene="yusS" /locus_tag="BSU_32910" /old_locus_tag="BSU32910" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="conserved enzyme of unknown function" /protein_id="NP_391170.1" /db_xref="EnsemblGenomes-Gn:BSU32910" /db_xref="EnsemblGenomes-Tr:CAB15280" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG14031" /db_xref="UniProtKB/Swiss-Prot:O32185" /translation="MNVLNKIALVTGGGTGIGKAASMELAKRGAIVAVNYSRSQSEAE ETVEMIQKAGGQAFAIQADVSKNSDVQDMIQAIVNTHGTVDILVNNASITRHIPMDDL EAATEDV*" /label="yusS CDS" gene complement(3028544..3028873) /gene="yusS" /locus_tag="BSU_32910" /old_locus_tag="BSU32910" /label="yusS gene" promotor_-10 complement(3028908..3028927) /Source="Nicolas_upshift_promotors" /id="U2578" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.972027972027972" /psig=1 /xcortree=1537 /SigmaFactorBS="atcaatctgagtgatatctagtatctttaacaatCATTATAC gtaacatcaaagcTGGATTACAATGGAATCAGAaatatactttagtcaacagcaagga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 3028915..3028922 /Source="Nicolas_upshift_promotors" /id="U2579" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.707292707292707" /psig="0.998001998001998" /xcortree=1789 /SigmaFactorBS="tgctgttgactaaagtatatttctgattCCATTGTAatccag ctttgatgTTACGTATAATGATTGTTAAagatactagatatcactcagattgatagta a" /listShort="yusT" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3028922) /Source="Nicolas_upshifts" /id="U2578" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.972027972027972" /psig=1 /xcortree=1537 /SigmaFactorBS="atcaatctgagtgatatctagtatctttaacaatCATTATAC gtaacatcaaagcTGGATTACAATGGAATCAGAaatatactttagtcaacagcaagga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3028937..3028956 /Source="Nicolas_upshift_promotors" /id="U2579" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.707292707292707" /psig="0.998001998001998" /xcortree=1789 /SigmaFactorBS="tgctgttgactaaagtatatttctgattCCATTGTAatccag ctttgatgTTACGTATAATGATTGTTAAagatactagatatcactcagattgatagta a" /listShort="yusT" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3028941..3028948) /Source="Nicolas_upshift_promotors" /id="U2578" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.972027972027972" /psig=1 /xcortree=1537 /SigmaFactorBS="atcaatctgagtgatatctagtatctttaacaatCATTATAC gtaacatcaaagcTGGATTACAATGGAATCAGAaatatactttagtcaacagcaagga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3028947 /Source="Nicolas_upshifts" /id="U2579" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.707292707292707" /psig="0.998001998001998" /xcortree=1789 /SigmaFactorBS="tgctgttgactaaagtatatttctgattCCATTGTAatccag ctttgatgTTACGTATAATGATTGTTAAagatactagatatcactcagattgatagta a" /listShort="yusT" /GFF_Attribute="listLong" /label="upshifts" CDS 3029007..3029894 /gene="yusT" /locus_tag="BSU_32920" /old_locus_tag="BSU32920" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12169591, 17526699, 27965289" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12169591, 17526699, 27965289; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of unknown specificity(LysR family)" /protein_id="NP_391171.1" /db_xref="EnsemblGenomes-Gn:BSU32920" /db_xref="EnsemblGenomes-Tr:CAB15281" /db_xref="GOA:O32186" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG14032" /db_xref="UniProtKB/Swiss-Prot:O32186" /translation="MESGDLRVFQMVAREGTITKAALQLGYVQSNVTARIQQLEAELG TTLFLRHNRGMTLSASGKLLLDYANKIIGLLDEASKALSSSAEPSGPLMIGCTQTTAA VRLPKLLASYYEEHPNVQLSLTTGHTQFLLDKVLRYELDGAFIGCECHHPELESYPAF EEEPVVVSAASVPDVEEAITKPILVYSTGCSYRETLEKWLRSVGVTQPVIMEFGTLEA IIGGVTAGLGISLLPRTVVQKHEAEGSIRLYPLPEALSQMKTEFIVRKDSFISSALRT FMDSFTPVKTAESQKSSLL*" /label="yusT CDS" gene 3029007..3029894 /gene="yusT" /locus_tag="BSU_32920" /old_locus_tag="BSU32920" /label="yusT gene" CDS complement(3029914..3030201) /gene="yusU" /locus_tag="BSU_32930" /old_locus_tag="BSU32930" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22078549" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391172.1" /db_xref="EnsemblGenomes-Gn:BSU32930" /db_xref="EnsemblGenomes-Tr:CAB15282" /db_xref="InterPro:IPR020393" /db_xref="SubtiList:BG14033" /db_xref="UniProtKB/Swiss-Prot:O32187" /translation="MRKLLAVFSKGRWKMEQKLQEQLDGLLEKYTELLLGETNDELKE EVKQWILYTHIAKSMPPLAKHWNATYPDAKQGIKEIIQHIKELNEAHRNKQ*" /label="yusU CDS" gene complement(3029914..3030201) /gene="yusU" /locus_tag="BSU_32930" /old_locus_tag="BSU32930" /label="yusU gene" downshifts complement(3029926) /Source="Nicolas_upshifts" /id="D1701" /incds=0 /nref=113 /ntot=280 /MaxReadThrough="1.05563" /MaxDrop="5.97768" /score="17.1690128" /energy="-13.2" /TU="NA" /idTUdmin="U2580" /TUdmin="-14" /isTUend="TRUE" /label="downshifts" CDS complement(3030226..3031053) /gene="feuV" /locus_tag="BSU_32940" /old_locus_tag="BSU32940" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 16672620, 24847778, 25288929" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 16672620, 24847778, 25288929; Product type t: transporter" /codon_start=1 /transl_table=11 /product="iron(III)-siderophore transporter (ATP binding component)" /protein_id="NP_391173.1" /db_xref="EnsemblGenomes-Gn:BSU32940" /db_xref="EnsemblGenomes-Tr:CAB15283" /db_xref="GOA:O32188" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG14034" /db_xref="UniProtKB/Swiss-Prot:O32188" /translation="MGMSAISTETLSLGYGDAVIIDELNLTIPKGEITVFIGSNGCGK STLLRSLARLMKPRGGSVLLEGRAIAKLPTKEVAKELAILPQGPSAPEGLTVHQLVKQ GRYPYQNWLKQWSKEDEEAVERALKATKLEDMADRAVDSLSGGQRQRAWIAMTLAQET DIILLDEPTTYLDMTHQIEILDLLFELNEKEDRTIVMVLHDLNLACRYAHHLVAIKDK RIYAEGRPEEVITCDLVQNVFSMNCQVTQDPLFGTPLCIPHGRGRCIVQEAAFTSHG* " /label="feuV CDS" gene complement(3030226..3031053) /gene="feuV" /locus_tag="BSU_32940" /old_locus_tag="BSU32940" /label="feuV gene" downshifts complement(3030242) /Source="Nicolas_upshifts" /id="D1702" /incds=0 /nref=2 /ntot=77 /MaxReadThrough="5.36684" /MaxDrop="3.19022" /score="11.3999731" /energy="-19.8" /TU="U2580" /idTUdmin="U2581" /TUdmin=220 /isTUend="FALSE" /label="downshifts" S_feature complement(3031054..3031191) /Source="Nicolas_S_feature" /locus_tag="new_3379940_3380077_c" /HighExp="T-5.40H, Paraq, H2O2, GM-0.2, HiOs, GM 5, dia15, GM 25, T-3.40H, GM 45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="1, 0.991" /TUlongSig="NA" /TUlongPSig="NA" /label="S1267" promotor_-10 complement(3031176..3031195) /Source="Nicolas_upshift_promotors" /id="U2580" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.463536463536464" /psig=1 /xcortree=2101 /SigmaFactorBS="taaacgtcaattatgtccataaaactaattgaaaatgATTTt caaagtcagtgtttTCTGCTACAATGAGGGATATatgaccatatcaaatggctgaata t" /listShort="S1267, yusV, yusU" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3031191) /Source="Nicolas_upshifts" /id="U2580" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.463536463536464" /psig=1 /xcortree=2101 /SigmaFactorBS="taaacgtcaattatgtccataaaactaattgaaaatgATTTt caaagtcagtgtttTCTGCTACAATGAGGGATATatgaccatatcaaatggctgaata t" /listShort="S1267, yusV, yusU" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3031211..3031214) /Source="Nicolas_upshift_promotors" /id="U2580" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.463536463536464" /psig=1 /xcortree=2101 /SigmaFactorBS="taaacgtcaattatgtccataaaactaattgaaaatgATTTt caaagtcagtgtttTCTGCTACAATGAGGGATATatgaccatatcaaatggctgaata t" /listShort="S1267, yusV, yusU" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3031271..3031708) /gene="cotNW" /locus_tag="BSU_32950" /old_locus_tag="BSU32950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 26497467; Product type m : membrane component" /codon_start=1 /transl_table=11 /product="spore lipoprotein" /protein_id="NP_391174.1" /db_xref="EnsemblGenomes-Gn:BSU32950" /db_xref="EnsemblGenomes-Tr:CAB15284" /db_xref="InterPro:IPR025623" /db_xref="SubtiList:BG14035" /db_xref="UniProtKB/Swiss-Prot:O32189" /translation="MHLIRAAGAVCLAVVLIAGCRFNEDQHQAEGENTAVTQLKSVPY SNFSLRVSYGDGEHNRYEGIYTKNGTQEKAEIQDKLSGVNQEGEEALDEMKMILSELS VTDQMAETEVIHSVLAAFNLDSHYDHIDLKLKLKDGSIREIKK*" /label="cotNW CDS" gene complement(3031271..3031708) /gene="cotNW" /locus_tag="BSU_32950" /old_locus_tag="BSU32950" /label="cotNW gene" promotor_-10 complement(3031732..3031750) /Source="Nicolas_upshift_promotors" /id="U2581" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1192 /SigmaFactorBS="aatgccccggctttttcaattcttctcTGAATGaggatttca ttctctGGATATACCTAAAATAAATggaatcctacaggggggaaacatatgcatttga t" /listShort="yusW, S1267, yusV" /listLong="yusU" /label="promotor_-10" upshifts complement(3031738) /Source="Nicolas_upshifts" /id="U2581" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1192 /SigmaFactorBS="aatgccccggctttttcaattcttctcTGAATGaggatttca ttctctGGATATACCTAAAATAAATggaatcctacaggggggaaacatatgcatttga t" /listShort="yusW, S1267, yusV" /listLong="yusU" /label="upshifts" promotor_-35 complement(3031766..3031771) /Source="Nicolas_upshift_promotors" /id="U2581" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=1192 /SigmaFactorBS="aatgccccggctttttcaattcttctcTGAATGaggatttca ttctctGGATATACCTAAAATAAATggaatcctacaggggggaaacatatgcatttga t" /listShort="yusW, S1267, yusV" /listLong="yusU" /label="promotor_-35" CDS complement(3031818..3033326) /gene="yusYc" /locus_tag="BSU_32960" /old_locus_tag="BSU32960" /EC_number="3.4.24.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 11741842; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="oligoendopeptidase; C-terminal part of YusY" /db_xref="SubtiList:BG14037" /translation="GLMNRLSADFQSSLVTLDHKLVDINQDVWNELLTKPGLRDVSYI LNERRQRVAEKLSPGKEKLIGNLAVDGYHAWSDLYNMVVGKMTIPYEENGENKQLSVG QAENMMDHQDRTVRKTVYERFRQAWESKQDIFSSTLNHLAGFRLETYKARGWENVLKE PLQINRMKKETLDTMWQVITENKKPFVQFLNRKASMLGLEKLSWYDVEAPIGSDGKVY SYDEAANIITSQFSTFGKKLSSFTEKAFRDGWIEAEDRSGKRVGGFCTSFPDSGESRI FMTFSGSASNVSTLAHELGHAFHQEAMLNVRPLNRSYAMNVAETASTFAEMIVADATV QQAETREEKLVLLEDKVQRSVAFFMNIHARFLFETRFYEERKRGVVPASRLNELMEEA QREAYCNALEEYHPLFWASKLHFHITRVPFYNFPYTFGYLFSLGIYALALEEKDTFEE KYMALLRDTASMTVEDLAMKHLGADITKRDFWENAIKLAVRDAETFLQMTES*" /label="yusYc CDS" gene complement(3031818..3033326) /gene="yusYc" /locus_tag="BSU_32960" /old_locus_tag="BSU32960" /pseudo /label="yusYc gene" downshifts complement(3031839) /Source="Nicolas_upshifts" /id="D1703" /incds=0 /nref=125 /ntot=240 /MaxReadThrough="2.57385" /MaxDrop="6.5698" /score="6.83314975" /energy="-12" /TU="NA" /idTUdmin="U2582" /TUdmin="-13" /isTUend="TRUE" /label="downshifts" CDS complement(3033317..3033613) /gene="yusYn" /locus_tag="BSU_32970" /old_locus_tag="BSU32970" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 11741842; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="oligoendopeptidase; N-terminal part of YusY" /translation="MALQGVGQRWDLDSFFKGGSQSEEFKGYIEKLSQSLRAFQDRTD AFQVPESPEEAEGLTALLDLFEQTSVKLQQAGAFVACLQAQNINDQKAIEHQAS*" /label="yusYn CDS" gene complement(3033317..3033613) /gene="yusYn" /locus_tag="BSU_32970" /old_locus_tag="BSU32970" /pseudo /label="yusYn gene" promotor_-10 complement(3033636..3033655) /Source="Nicolas_upshift_promotors" /id="U2582" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.708291708291708" /psig=1 /xcortree=2899 /SigmaFactorBS="actatcctgaacacgaaatgacgcctgtaatagaaatttTTA TacaataattcagaaTTGTTCTATAATAGAACGAAagaaggaaaggggttttgtgata t" /listShort="yusY, yusY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3033652) /Source="Nicolas_upshifts" /id="U2582" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.708291708291708" /psig=1 /xcortree=2899 /SigmaFactorBS="actatcctgaacacgaaatgacgcctgtaatagaaatttTTA TacaataattcagaaTTGTTCTATAATAGAACGAAagaaggaaaggggttttgtgata t" /listShort="yusY, yusY" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3033670..3033673) /Source="Nicolas_upshift_promotors" /id="U2582" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.708291708291708" /psig=1 /xcortree=2899 /SigmaFactorBS="actatcctgaacacgaaatgacgcctgtaatagaaatttTTA TacaataattcagaaTTGTTCTATAATAGAACGAAagaaggaaaggggttttgtgata t" /listShort="yusY, yusY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3033690..3033695 /Source="Nicolas_upshift_promotors" /id="U2583" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.975024975024975" /psig="0.998001998001998" /xcortree=2942 /SigmaFactorBS="atagaacaattctgaattattgtataaaaatttctattacag gCGTCATttcgtgttcagGATAGTACAATAGCTGTAGCagtttaataggagggttagg a" /listShort="yusZ, mrgA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3033707..3033726 /Source="Nicolas_upshift_promotors" /id="U2583" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.975024975024975" /psig="0.998001998001998" /xcortree=2942 /SigmaFactorBS="atagaacaattctgaattattgtataaaaatttctattacag gCGTCATttcgtgttcagGATAGTACAATAGCTGTAGCagtttaataggagggttagg a" /listShort="yusZ, mrgA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3033707 /Source="Nicolas_upshifts" /id="U2583" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.975024975024975" /psig="0.998001998001998" /xcortree=2942 /SigmaFactorBS="atagaacaattctgaattattgtataaaaatttctattacag gCGTCATttcgtgttcagGATAGTACAATAGCTGTAGCagtttaataggagggttagg a" /listShort="yusZ, mrgA" /GFF_Attribute="listLong" /label="upshifts" CDS 3033747..3034589 /gene="yusZ" /locus_tag="BSU_32980" /old_locus_tag="BSU32980" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative short-chain acyl dehydrogenase" /protein_id="NP_391177.1" /db_xref="EnsemblGenomes-Gn:BSU32980" /db_xref="EnsemblGenomes-Tr:CAB15287" /db_xref="GOA:P37959" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10863" /db_xref="UniProtKB/Swiss-Prot:P37959" /translation="MNKKIAIVTGASSGFGLLAAVKLARSFFVIATSRQPEKAEQLRE LAAAHNVSDSIHITALDVTDEQSIVSFGKAVSAYAPIDLLVNNAGTAYGGFIEDVPME HFRQQFETNVFGVIHVTKTVLPYIRKHGGAKIINVSSISGLTGFPALSPYVSSKHALE GFSESLRIELLPFGIETALIEPGSYKTSIWSTSLSNFMSVPADDSAYHQYYKKILSYV QKNGEESGDPQEVADLIYQLATKQHIKNLRYPIGKGIKLTLLFRSLFPWSAWESILKK KLFS*" /label="yusZ CDS" gene 3033747..3034589 /gene="yusZ" /locus_tag="BSU_32980" /old_locus_tag="BSU32980" /label="yusZ gene" promotor_-35 3034119..3034125 /Source="Nicolas_upshift_promotors" /id="U2584" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=826 /SigmaFactorBS="tgtgatccatgtgacaaaaaccgtgctgcctTACATAAgaaa gcatggcggcGCAAAGATTATAaacgtgagcagcatcagcggactgacaggattccca g" /GFF_Attribute="listShort" /listLong="mrgA" /label="promotor_-35" promotor_-10 3034140..3034151 /Source="Nicolas_upshift_promotors" /id="U2584" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=826 /SigmaFactorBS="tgtgatccatgtgacaaaaaccgtgctgcctTACATAAgaaa gcatggcggcGCAAAGATTATAaacgtgagcagcatcagcggactgacaggattccca g" /GFF_Attribute="listShort" /listLong="mrgA" /label="promotor_-10" upshifts 3034148 /Source="Nicolas_upshifts" /id="U2584" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=826 /SigmaFactorBS="tgtgatccatgtgacaaaaaccgtgctgcctTACATAAgaaa gcatggcggcGCAAAGATTATAaacgtgagcagcatcagcggactgacaggattccca g" /GFF_Attribute="listShort" /listLong="mrgA" /label="upshifts" promotor_-35 3034616..3034623 /Source="Nicolas_upshift_promotors" /id="U2585" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.465534465534466" /psig=1 /xcortree=1535 /SigmaFactorBS="aaaaagctattcagctgatctaaattataattattataattt agTATTGATTtttatttagtaTATGATATAATTAAGTCAACagatcacaaggaggacg t" /listShort="mrgA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3034632 /Source="Nicolas_upshifts" /id="U2585" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.465534465534466" /psig=1 /xcortree=1535 /SigmaFactorBS="aaaaagctattcagctgatctaaattataattattataattt agTATTGATTtttatttagtaTATGATATAATTAAGTCAACagatcacaaggaggacg t" /listShort="mrgA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3034635..3034654 /Source="Nicolas_upshift_promotors" /id="U2585" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.465534465534466" /psig=1 /xcortree=1535 /SigmaFactorBS="aaaaagctattcagctgatctaaattataattattataattt agTATTGATTtttatttagtaTATGATATAATTAAGTCAACagatcacaaggaggacg t" /listShort="mrgA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3034679..3035140 /gene="mrgA" /locus_tag="BSU_32990" /old_locus_tag="BSU32990" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12029044, 8709848, 21057011, 22194458, 24123749, 28434086" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12029044, 8709848, 21057011, 22194458, 24123749, 28434086; Product type f : factor" /codon_start=1 /transl_table=11 /product="metalloregulation DNA-binding stress protein" /protein_id="NP_391178.1" /db_xref="EnsemblGenomes-Gn:BSU32990" /db_xref="EnsemblGenomes-Tr:CAB15288" /db_xref="GOA:P37960" /db_xref="InterPro:IPR002177" /db_xref="InterPro:IPR008331" /db_xref="InterPro:IPR009078" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR023188" /db_xref="PDB:2CHP" /db_xref="SubtiList:BG10864" /db_xref="UniProtKB/Swiss-Prot:P37960" /translation="MKTENAKTNQTLVENSLNTQLSNWFLLYSKLHRFHWYVKGPHFF TLHEKFEELYDHAAETVDTIAERLLAIGGQPVATVKEYTEHASITDGGNETSASEMVQ ALVNDYKQISSESKFVIGLAEENQDNATADLFVGLIEEVEKQVWMLSSYLG*" /label="mrgA CDS" gene 3034679..3035140 /gene="mrgA" /locus_tag="BSU_32990" /old_locus_tag="BSU32990" /label="mrgA gene" downshifts 3035116 /Source="Nicolas_upshifts" /id="D1704" /incds=0 /nref=234 /ntot=274 /MaxReadThrough="1.7919" /MaxDrop="8.26581" /score="36.5549876" /energy="-13.3" /TU="NA" /idTUdmin="U2583" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3035184..3036560) /gene="htrB" /locus_tag="BSU_33000" /old_locus_tag="BSU33000" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11133960, 11717295, 16033468, 16911528, 22307758, 23937099, 24362423" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11133960, 11717295, 16033468, 16911528, 22307758, 23937099, 24362423; Product type f: factor" /codon_start=1 /transl_table=11 /product="protease-associated chaperone for the extracytoplasmic folding and quality control of exported proteins" /protein_id="NP_391180.2" /db_xref="EnsemblGenomes-Gn:BSU33000" /db_xref="EnsemblGenomes-Tr:CAB15290" /db_xref="GOA:Q9R9I1" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR001940" /db_xref="InterPro:IPR009003" /db_xref="InterPro:IPR036034" /db_xref="SubtiList:BG14155" /db_xref="UniProtKB/Swiss-Prot:Q9R9I1" /translation="MDYRRDGQNDQHQTEPSHTEQQNTENQKLIGHSEQELLDAPVSY EAGRQETASALEMEKQETAVKKEKKRRAAWLSPILGGIIGGGLMLGIAPYLPSDQNQA TETASANKQVQSDNFTTAPITNASNIADMVEDLEPTIVGISNIQTSQNNTFGTGGGSS SESESGTGSGVIFKKDSDKAYIITNNHVVEGANKLTVTLYNGETETAKLVGSDTITDL AVLEISGKNVKKVASFGDSSQLRTGEKVIAIGNPLGQQFSGTVTQGIISGLNRTIDVD TTQGTVEMNVLQTDAAINPGNSGGPLINASGQVIGINSLKVSESGVESLGFAIPSNDV EPIVDQLLQNGKVDRPFLGVQMIDMSQVPETYQENTLGLFGDQLGKGVYVKEVQANSP AEKAGIKSEDVIVKLNGKDVESSADIRQILYKDLKVGDKTTIQVLRKGKTKTLNATLT KQTESSSS*" /label="htrB CDS" gene complement(3035184..3036560) /gene="htrB" /locus_tag="BSU_33000" /old_locus_tag="BSU33000" /label="htrB gene" downshifts complement(3035192) /Source="Nicolas_upshifts" /id="D1705" /incds=0 /nref=206 /ntot=257 /MaxReadThrough="1.84997" /MaxDrop="6.39104" /score="17.1953741" /energy="-11.2" /TU="U2586" /idTUdmin="U2586" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" S_feature complement(3036561..3036732) /Source="Nicolas_S_feature" /locus_tag="new_3385447_3385618_c" /HighExp="SMMPr, T-0.40H, T-1.10H, M9-tran, T-1.40H, T1.0H, T0.30H, T1.30H, Etha, M/G" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.67259999999999998" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1268" promotor_-10 complement(3036713..3036732) /Source="Nicolas_upshift_promotors" /id="U2586" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=1764 /SigmaFactorBS="acggcaggcaattttcataatttcacatattcttttcatttt TATCCCACaatgtttgttTATGATATGGTTAAGGGAAGaaaggaagagaaaaagagcg a" /listShort="S1268, htrB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3036732) /Source="Nicolas_upshifts" /id="U2586" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=1764 /SigmaFactorBS="acggcaggcaattttcataatttcacatattcttttcatttt TATCCCACaatgtttgttTATGATATGGTTAAGGGAAGaaaggaagagaaaaagagcg a" /listShort="S1268, htrB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3036743..3036750) /Source="Nicolas_upshift_promotors" /id="U2586" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.883116883116883" /psig=1 /xcortree=1764 /SigmaFactorBS="acggcaggcaattttcataatttcacatattcttttcatttt TATCCCACaatgtttgttTATGATATGGTTAAGGGAAGaaaggaagagaaaaagagcg a" /listShort="S1268, htrB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3036793..3036812) /Source="Nicolas_upshift_promotors" /id="U2588" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2391 /SigmaFactorBS="cctcatcttcaactagataaatggtgtatgacaaggcTCTTC ACAtcctttcaacgtcaTTATAAACTAGTTTTAACATacggcaggcaattttcataat t" /GFF_Attribute="listShort" /listLong="S1268, htrB" /label="promotor_-10" misc_feature 3036803..3036822 /Source="Nicolas_upshift_promotors" /id="U2587" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.761238761238761" /psig="0.994005994005994" /xcortree=2013 /SigmaFactorBS="gggataaaaatgaaaagaatatgtgaaattatgaaaattgcc tgccgtatgttaaaacTAGTTTATAATGACGTTGAAaggatgtgaagagccttgtcat a" /listShort="cssR, cssS" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3036805 /Source="Nicolas_upshifts" /id="U2587" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.761238761238761" /psig="0.994005994005994" /xcortree=2013 /SigmaFactorBS="gggataaaaatgaaaagaatatgtgaaattatgaaaattgcc tgccgtatgttaaaacTAGTTTATAATGACGTTGAAaggatgtgaagagccttgtcat a" /listShort="cssR, cssS" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(3036811) /Source="Nicolas_upshifts" /id="U2588" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2391 /SigmaFactorBS="cctcatcttcaactagataaatggtgtatgacaaggcTCTTC ACAtcctttcaacgtcaTTATAAACTAGTTTTAACATacggcaggcaattttcataat t" /GFF_Attribute="listShort" /listLong="S1268, htrB" /label="upshifts" S_feature complement(3036813..3037876) /Source="Nicolas_S_feature" /locus_tag="new_3385699_3386762_c" /HighExp="T1.0H, T0.30H, T1.30H, C30, T2.0H, G135, G180, T2.30H, ferm, G150" /AntisenseName="cssR" /AntisenseCor="0.115381389160342" /AntisenseRegPval="-1.2" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1269" promotor_-35 complement(3036827..3036834) /Source="Nicolas_upshift_promotors" /id="U2588" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=2391 /SigmaFactorBS="cctcatcttcaactagataaatggtgtatgacaaggcTCTTC ACAtcctttcaacgtcaTTATAAACTAGTTTTAACATacggcaggcaattttcataat t" /GFF_Attribute="listShort" /listLong="S1268, htrB" /label="promotor_-35" CDS 3036838..3037515 /gene="cssR" /locus_tag="BSU_33010" /old_locus_tag="BSU33010" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11555295, 11717295, 12270824, 15856219, 16911528, 17586671, 27026185" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11555295, 11717295, 12270824, 15856219, 16911528, 17586671, 27026185; Product type r: regulator" /codon_start=1 /transl_table=11 /product="folding stress-sensitive two-component response regulator" /protein_id="NP_391181.1" /db_xref="EnsemblGenomes-Gn:BSU33010" /db_xref="EnsemblGenomes-Tr:CAB15291" /db_xref="GOA:O32192" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG14131" /db_xref="UniProtKB/Swiss-Prot:O32192" /translation="MSYTIYLVEDEDNLNELLTKYLENEGWNITSFTKGEDARKKMTP SPHLWILDIMLPDTDGYTLIKEIKAKDPDVPVIFISARDADIDRVLGLELGSNDYISK PFLPRELIIRVQKLLQLVYKEAPPVQKNEIAVSSYRVAEDAREVYDENGNIINLTSKE FDLLLLFIHHKGHPYSREDILLKVWGHDYFGTDRVVDDLVRRLRRKMPELKVETIYGF GYRMMSS*" /label="cssR CDS" gene 3036838..3037515 /gene="cssR" /locus_tag="BSU_33010" /old_locus_tag="BSU33010" /label="cssR gene" CDS 3037512..3038867 /gene="cssS" /locus_tag="BSU_33020" /old_locus_tag="BSU33020" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11555295, 11717295, 12270824, 15856219, 16911528, 17586671, 27026185" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11555295, 11717295, 12270824, 15856219, 16911528, 17586671, 27026185; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="folding stress-sensitive two-component sensor histidine kinase" /protein_id="NP_391182.2" /db_xref="EnsemblGenomes-Gn:BSU33020" /db_xref="EnsemblGenomes-Tr:CAB15292" /db_xref="GOA:O32193" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG14132" /db_xref="UniProtKB/Swiss-Prot:O32193" /translation="MKNKPLAFQIWVVISGILLAISILLLVLFSNTLRDFFTNETYTT IENEQHVLTEYRLPGSIERRYYSEEATAPTTVRSVQHVLLPENEEASSDKDLSILSSS FIHKVYKLADKQEAKKKRYSADVNGEKVFFVIKKGLSVNGQSAMMLSYALDSYRDDLA YTLFKQLLFIIAVVILLSWIPAIWLAKYLSRPLVSFEKHVKRISEQDWDDPVKVDRKD EIGKLGHTIEEMRQKLVQKDETERTLLQNISHDLKTPVMVIRGYTQSIKDGIFPKGDL ENTVDVIECEALKLEKKIKDLLYLTKLDYLAKQKVQHDMFSIVEVTEEVIERLKWARK ELSWEIDVEEDILMPGDPEQWNKLLENILENQIRYAETKIEISMKQDDRNIVITIKND GPHIEDEMLSSLYEPFNKGKKGEFGIGLSIVKRILTLHKASISIENDKTGVTYRIAVP K*" /label="cssS CDS" gene 3037512..3038867 /gene="cssS" /locus_tag="BSU_33020" /old_locus_tag="BSU33020" /label="cssS gene" S_feature complement(3037966..3038894) /Source="Nicolas_S_feature" /locus_tag="new_3386852_3387780_c" /HighExp="T1.0H, T0.30H, T1.30H, T2.0H, T2.30H, ferm, C30, LPhT, T-1.10H, Lbstat" /AntisenseName="cssS" /AntisenseCor="0.27217686232372901" /AntisenseRegPval="-5.2" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigD, SigH, SigA" /TUshortPSig="1, 0.869, 1, 0.999, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1270" downshifts 3038835 /Source="Nicolas_upshifts" /id="D1706" /incds=0 /nref=61 /ntot=203 /MaxReadThrough="0.95076" /MaxDrop="4.47937" /score="13.0972324" /energy="-9.7" /TU="NA" /idTUdmin="U2587" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(3038895..3039059) /gene="spxO" /locus_tag="BSU_33029" /old_locus_tag="BSU33029" /experiment="publication(s) with functional evidences, PMID:21378193" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21378193; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of SpxA degradation" /protein_id="YP_003097785.1" /db_xref="EnsemblGenomes-Gn:BSU33029" /db_xref="EnsemblGenomes-Tr:CAX52691" /db_xref="GOA:O32302" /db_xref="UniProtKB/Swiss-Prot:O32302" /translation="MRELDEMISRLRNRGIKVEKVKYPKQTLSEKKWVHQCKQPLKTN YRDFNGYSFT*" /label="spxO CDS" gene complement(3038895..3039059) /gene="spxO" /locus_tag="BSU_33029" /old_locus_tag="BSU33029" /label="spxO gene" promotor_-35 3039083..3039090 /Source="Nicolas_upshift_promotors" /id="U2589" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig=1 /xcortree=1903 /SigmaFactorBS="tctcattctagattcaccctttcgcttgaGCTTTGACcattc ggtcatctCAATTTATAATATAAATAATacatgataaaaaaacaagttacaataaggt t" /listShort="S1271, yuxN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3039104..3039123 /Source="Nicolas_upshift_promotors" /id="U2589" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig=1 /xcortree=1903 /SigmaFactorBS="tctcattctagattcaccctttcgcttgaGCTTTGACcattc ggtcatctCAATTTATAATATAAATAATacatgataaaaaaacaagttacaataaggt t" /listShort="S1271, yuxN" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(3039108..3039127) /Source="Nicolas_upshift_promotors" /id="U2590" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.477522477522478" /psig=1 /xcortree=3229 /SigmaFactorBS="tatagtcacaccgtctgttataaaattaaccttATTGTAACt tgtttttttatcATGTATTATTTATATTATAAattgagatgaccgaatggtcaaagct c" /listShort="yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3039114..3039226 /Source="Nicolas_S_feature" /locus_tag="new_3388000_3388112" /HighExp="dia5, Diami, T0.30H, T-0.40H, T0.0H, dia15, Salt, ferm, G135, T-1.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1271" upshifts 3039114 /Source="Nicolas_upshifts" /id="U2589" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig=1 /xcortree=1903 /SigmaFactorBS="tctcattctagattcaccctttcgcttgaGCTTTGACcattc ggtcatctCAATTTATAATATAAATAATacatgataaaaaaacaagttacaataaggt t" /listShort="S1271, yuxN" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(3039121) /Source="Nicolas_upshifts" /id="U2590" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.477522477522478" /psig=1 /xcortree=3229 /SigmaFactorBS="tatagtcacaccgtctgttataaaattaaccttATTGTAACt tgtttttttatcATGTATTATTTATATTATAAattgagatgaccgaatggtcaaagct c" /listShort="yuzO, S1270" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3039123..3039401) /Source="Nicolas_S_feature" /locus_tag="new_3388009_3388287_c" /HighExp="Etha, Gly, S2, Glucon, Pyr, G/S, S1, Lbstat, Cold, HiTm" /AntisenseName="yuxN" /AntisenseCor="-0.128326996122899" /AntisenseRegPval="-1.5" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD, SigH, SigA" /TUshortPSig="0.869, 1, 0.999, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1272" promotor_-35 complement(3039141..3039148) /Source="Nicolas_upshift_promotors" /id="U2590" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.477522477522478" /psig=1 /xcortree=3229 /SigmaFactorBS="tatagtcacaccgtctgttataaaattaaccttATTGTAACt tgtttttttatcATGTATTATTTATATTATAAattgagatgaccgaatggtcaaagct c" /listShort="yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3039227..3040102 /gene="yuxN" /locus_tag="BSU_33030" /old_locus_tag="BSU33030" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_391183.1" /db_xref="EnsemblGenomes-Gn:BSU33030" /db_xref="EnsemblGenomes-Tr:CAB15293" /db_xref="GOA:P40950" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR023772" /db_xref="SubtiList:BG11072" /db_xref="UniProtKB/Swiss-Prot:P40950" /translation="MKEKEKLIIETALKLFAQKGYNSTSVQEIAKECKISKGAFYIYF PSKEALLLSMLNYYYDKTFTRILNIKTKGDSPRTAYRKQLTVLYENILEHKDFISMQL KEGSLPYTEEVEQCAKKIRQSSLQFHIDSLLNIYGKKAEPYTAELCFLIEGISQIYLE CMILLGYTVKPSQLADIIMNRIDDMVKGMSERNDKPFITLEEASSLFGPLTHGRPDPL TESIVKSLRDKINSLNTNSSLELSESLDILEAEMKKKTPKLAIIKGMIHNLTESEALA KDAEQLKYLLKQQHI*" /label="yuxN CDS" gene 3039227..3040102 /gene="yuxN" /locus_tag="BSU_33030" /old_locus_tag="BSU33030" /label="yuxN gene" promotor_-10 complement(3039391..3039410) /Source="Nicolas_upshift_promotors" /id="U2591" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.627372627372627" /psig="0.869130869130869" /xcortree=103 /SigmaFactorBS="ccgttctggggctgtcgcccttcgttttaaTATTTAAAattc gggtaaacgTTTTATCATAATAGTAGTTCagcatagagagaagaagcgcttctttcga a" /listShort="S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3039401) /Source="Nicolas_upshifts" /id="U2591" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.627372627372627" /psig="0.869130869130869" /xcortree=103 /SigmaFactorBS="ccgttctggggctgtcgcccttcgttttaaTATTTAAAattc gggtaaacgTTTTATCATAATAGTAGTTCagcatagagagaagaagcgcttctttcga a" /listShort="S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3039403..3039944) /Source="Nicolas_S_feature" /locus_tag="new_3388289_3388830_c" /HighExp="LBGstat, Cold, S2, Glucon, S1, Pyr, G/S, C30, GM 10, GM-0.1" /AntisenseName="yuxN" /AntisenseCor="-0.341746670828522" /AntisenseRegPval="-8.1" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigH, SigA" /TUshortPSig="1, 0.999, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1273" promotor_-35 complement(3039424..3039431) /Source="Nicolas_upshift_promotors" /id="U2591" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.627372627372627" /psig="0.869130869130869" /xcortree=103 /SigmaFactorBS="ccgttctggggctgtcgcccttcgttttaaTATTTAAAattc gggtaaacgTTTTATCATAATAGTAGTTCagcatagagagaagaagcgcttctttcga a" /listShort="S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3039936..3039954) /Source="Nicolas_upshift_promotors" /id="U2592" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2843 /SigmaFactorBS="ccagcttcggtgtttttttcttcatttctgCTTCAAGTatgt ccaagctcTCCGATAATTCAAGAGAGGagtttgtgtttaagctgttaattttgtcacg t" /listShort="S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3039944) /Source="Nicolas_upshifts" /id="U2592" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2843 /SigmaFactorBS="ccagcttcggtgtttttttcttcatttctgCTTCAAGTatgt ccaagctcTCCGATAATTCAAGAGAGGagtttgtgtttaagctgttaattttgtcacg t" /listShort="S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3039946..3040075) /Source="Nicolas_S_feature" /locus_tag="new_3388832_3388961_c" /HighExp="S2, S1, G/S, Glucon, Pyr, T3.30H, M9-stat, BT, Cold, T4.0H" /AntisenseName="yuxN" /AntisenseCor="-0.30886083736579201" /AntisenseRegPval="-6.6" /CDS_PredictionProba="NA" /TUshortSig="SigH, SigA" /TUshortPSig="0.999, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1274" promotor_-35 complement(3039967..3039974) /Source="Nicolas_upshift_promotors" /id="U2592" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2843 /SigmaFactorBS="ccagcttcggtgtttttttcttcatttctgCTTCAAGTatgt ccaagctcTCCGATAATTCAAGAGAGGagtttgtgtttaagctgttaattttgtcacg t" /listShort="S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3040077 /Source="Nicolas_upshifts" /id="D1707" /incds=0 /nref=30 /ntot=182 /MaxReadThrough="3.14099" /MaxDrop="3.7614" /score="-3.47814442" /energy="-13.6" /TU="NA" /idTUdmin="U2589" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" downshifts complement(3040120) /Source="Nicolas_upshifts" /id="D1708" /incds=0 /nref=1 /ntot=31 /MaxReadThrough="5.30537" /MaxDrop="3.29426" /score="-2.73895091" /energy="-13.6" /TU="U2593,U2594" /idTUdmin="U2591" /TUdmin="-1584" /isTUend="FALSE" /label="downshifts" CDS complement(3040138..3041526) /gene="fumC" /locus_tag="BSU_33040" /old_locus_tag="BSU33040" /EC_number="4.2.1.2" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /function="16.7: Manage energy" /experiment="publication(s) with functional evidences, PMID:2509422, 3130545, 3923430, 9647666, 22914898, 28032445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2509422, 3130545, 3923430, 9647666, 22914898, 28032445; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="fumarate hydratase" /protein_id="NP_391184.1" /db_xref="EnsemblGenomes-Gn:BSU33040" /db_xref="EnsemblGenomes-Tr:CAB15294" /db_xref="GOA:P07343" /db_xref="InterPro:IPR000362" /db_xref="InterPro:IPR005677" /db_xref="InterPro:IPR008948" /db_xref="InterPro:IPR018951" /db_xref="InterPro:IPR020557" /db_xref="InterPro:IPR022761" /db_xref="InterPro:IPR024083" /db_xref="SubtiList:BG10384" /db_xref="UniProtKB/Swiss-Prot:P07343" /translation="MEYRIERDTMGEVKVPADKFWGAQTQRSKENFKIGSEKMPMRVV KAFAILKRSTALANKRLGNLDAEKAEAIAAVCDDVLKGKYDDNFPLVVWQTGSGTQSN MNMNEVVANRATALLKEKNSDQTIHPNDDVNRSQSSNDTFPTAMHVAAVLAVYEQLVP ALDQLRNTLDEKAKAYNDIVKIGRTHLQDATPLTLGQEISGWVHMLDRSKEMILEATD KMRALAIGGTAVGTGINAHPEFGELVSEEITKLTGQTFSSSPNKFHALTSHDEITYAH GALKALAADLMKIANDVRWLASGPRCGIGEIVIPENEPGSSIMPGKVNPTQSEALTMI AAQIMGNDATIGFAASQGNFELNVFKPVIIYNFLQSVQLLSDGMNSFHDKCAVGIEPN KETIQENLSNSLMLVTALNPHIGYENAAKIAKLAHKEGLTLKEAALKLELLTEEQFNE MVKPEDMVKPKA*" /label="fumC CDS" gene complement(3040138..3041526) /gene="fumC" /locus_tag="BSU_33040" /old_locus_tag="BSU33040" /label="fumC gene" upshifts complement(3041550) /Source="Nicolas_upshifts" /id="U2593" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3195 /SigmaFactorBS="gccaagatcgaaaaataaAAAGGATTTtttgtgtcatTGGCG AATTATGATCTATTgaagcaaccgttatggagggatacataaatggaatacagaattg a" /listShort="fumC, S1274, S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3041555..3041573) /Source="Nicolas_upshift_promotors" /id="U2593" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3195 /SigmaFactorBS="gccaagatcgaaaaataaAAAGGATTTtttgtgtcatTGGCG AATTATGATCTATTgaagcaaccgttatggagggatacataaatggaatacagaattg a" /listShort="fumC, S1274, S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3041584..3041592) /Source="Nicolas_upshift_promotors" /id="U2593" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=3195 /SigmaFactorBS="gccaagatcgaaaaataaAAAGGATTTtttgtgtcatTGGCG AATTATGATCTATTgaagcaaccgttatggagggatacataaatggaatacagaattg a" /listShort="fumC, S1274, S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3041593..3041778) /gene="yvzF" /locus_tag="BSU_33049" /old_locus_tag="BSU33049" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097786.1" /db_xref="EnsemblGenomes-Gn:BSU33049" /db_xref="EnsemblGenomes-Tr:CAX52692" /db_xref="InterPro:IPR025088" /db_xref="UniProtKB/Swiss-Prot:C0H3R3" /translation="MAQVRLAGKQEEIEQLIRSFEQHYDVSYTSKEYGRTNPKYKYSK DSRVYLELKLKSAKIEK*" /label="yvzF CDS" gene complement(3041593..3041778) /gene="yvzF" /locus_tag="BSU_33049" /old_locus_tag="BSU33049" /label="yvzF gene" downshifts 3041782 /Source="Nicolas_upshifts" /id="D1709" /incds=0 /nref=4 /ntot=100 /MaxReadThrough="1.13377" /MaxDrop="4.4478" /score="-3.47814442" /energy="-13.6" /TU="NA" /idTUdmin="U2595" /TUdmin="-748" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3041822..3041841) /Source="Nicolas_upshift_promotors" /id="U2594" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.566433566433566" /psig="0.996003996003996" /xcortree=2565 /SigmaFactorBS="atgaggtcacctcttatccaaaaccttagtagaggtTATCtt ttcctgttaaaaaAATGATATACTGTGTTAGAGtatttcatggagtaagtttttttat g" /listShort="yvzF, fumC, S1274, S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 3041831..3041837 /Source="Nicolas_upshift_promotors" /id="U2595" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=904 /SigmaFactorBS="ttcataaaaaaacttactccatgaaatactctaacacAGTAT ATcatttttttaacaGGAAAAGATAACctctactaaggttttggataagaggtgacct c" /listShort="gerAA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3041836) /Source="Nicolas_upshifts" /id="U2594" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.566433566433566" /psig="0.996003996003996" /xcortree=2565 /SigmaFactorBS="atgaggtcacctcttatccaaaaccttagtagaggtTATCtt ttcctgttaaaaaAATGATATACTGTGTTAGAGtatttcatggagtaagtttttttat g" /listShort="yvzF, fumC, S1274, S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3041851..3041862 /Source="Nicolas_upshift_promotors" /id="U2595" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=904 /SigmaFactorBS="ttcataaaaaaacttactccatgaaatactctaacacAGTAT ATcatttttttaacaGGAAAAGATAACctctactaaggttttggataagaggtgacct c" /listShort="gerAA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3041854 /Source="Nicolas_upshifts" /id="U2595" /multdbtbs="SigF,SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=904 /SigmaFactorBS="ttcataaaaaaacttactccatgaaatactctaacacAGTAT ATcatttttttaacaGGAAAAGATAACctctactaaggttttggataagaggtgacct c" /listShort="gerAA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3041857..3041860) /Source="Nicolas_upshift_promotors" /id="U2594" /multdbtbs="SigA,SigA" /comp="M4" /sig="SigA" /pcomp="0.566433566433566" /psig="0.996003996003996" /xcortree=2565 /SigmaFactorBS="atgaggtcacctcttatccaaaaccttagtagaggtTATCtt ttcctgttaaaaaAATGATATACTGTGTTAGAGtatttcatggagtaagtttttttat g" /listShort="yvzF, fumC, S1274, S1273, S1272, yuzO, S1270" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3041896..3043344 /gene="gerAA" /locus_tag="BSU_33050" /old_locus_tag="BSU33050" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:11418573, 15774895, 16740944, 28605069" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11418573, 15774895, 16740944, 28605069; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="component of the GerA germination receptor" /protein_id="NP_391185.2" /db_xref="EnsemblGenomes-Gn:BSU33050" /db_xref="EnsemblGenomes-Tr:CAB15295" /db_xref="GOA:P07868" /db_xref="InterPro:IPR004995" /db_xref="SubtiList:BG10385" /db_xref="UniProtKB/Swiss-Prot:P07868" /translation="MEQTEFKEYIHDNLALVLPKLKENDDLVKNKKMLANGLVFYYLY FSEMTDENKVSEAIKTLIKDEETLTLDQVKKRLDQLDARPVETAKKTIESILNGNCAV FINGLDKAYILTTGKKKTRSLTEPTTEKVVRGPKVAFVEDIDTNLALIRQRTSHPKLI TKKIMIGENKLKPAAIMYIEGKAKKSVIKEVKARLKNIQLEDIQDSGTLEELIEDNKY SPFPQIQNTERPDKVSSALFNGRVAILVDSSPFVLLVPVSLGILMQSPDDYYERWISA SLIRSLRFASIFITLFLSSIYITLVSFHQGLLPTALAVTISANRENVPFPPIFEALLM EVTIELLREAGLRLPNPLGQTIGLVGGVVIGQAAVEANLVSSILVIVVSVIALASFTV PQYGMGLSFRVLRFISMFSAAILGLYGIILFMLVVYTHLTRQTSFGSPYFSPNGFFSL KNTDDSIIRLPIKNKPKEVNNPNEPKTDSTET*" /label="gerAA CDS" gene 3041896..3043344 /gene="gerAA" /locus_tag="BSU_33050" /old_locus_tag="BSU33050" /label="gerAA gene" S_feature complement(3042892..3045535) /Source="Nicolas_S_feature" /locus_tag="new_3391778_3394421_c" /HighExp="Cold, H2O2, G135, G180, Paraq, G150, Oxctl, T-5.40H, LBGstat, T-4.40H" /AntisenseName="gerAC" /AntisenseCor="-9.7163861003102397E-2" /AntisenseRegPval="-1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1275" CDS 3043313..3044410 /gene="gerAB" /locus_tag="BSU_33060" /old_locus_tag="BSU33060" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15774895, 15849754, 16740944, 16850406, 28605069" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15774895, 15849754, 16740944, 16850406, 28605069; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="component of the germination receptor GerA; putative transporter" /protein_id="NP_391186.1" /db_xref="EnsemblGenomes-Gn:BSU33060" /db_xref="EnsemblGenomes-Tr:CAB15296" /db_xref="GOA:P07869" /db_xref="InterPro:IPR004761" /db_xref="SubtiList:BG10386" /db_xref="UniProtKB/Swiss-Prot:P07869" /translation="MSQKQTPLKLNTFQGISIVANTMLGAGLLTLPRALTTKANTPDG WITLILEGFIFIFFIYLNTLIQKKHQYPSLFEYLKEGLGKWIGSIIGLLICGYFLGVA SFETRAMAEMVKFFLLERTPIQVIILTFICCGIYLMVGGLSDVSRLFPFYLTVTIIIL LIVFGISFKIFDINNLRPVLGEGLGPIANSLTVVSISFLGMEVMLFLPEHMKKKKYTF RYASLGFLIPIILYILTYIIVVGALTAPEVKTLIWPTISLFQSFELKGIFIERFESFL LVVWIIQFFTTFVIYGYFAANGLKKTFGLSTKTSMVIIGITVFYFSLWPDDANQVMMY SDYLGYIFVSLFLLPFILFFIVALKRRITTK*" /label="gerAB CDS" gene 3043313..3044410 /gene="gerAB" /locus_tag="BSU_33060" /old_locus_tag="BSU33060" /label="gerAB gene" CDS 3044407..3045528 /gene="gerAC" /locus_tag="BSU_33070" /old_locus_tag="BSU33070" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:11418573, 15774895, 16740944, 28605069" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11418573, 15774895, 16740944, 28605069; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="component of the germination receptor GerA" /protein_id="NP_391187.1" /db_xref="EnsemblGenomes-Gn:BSU33070" /db_xref="EnsemblGenomes-Tr:CAB15297" /db_xref="GOA:P07870" /db_xref="InterPro:IPR008844" /db_xref="SubtiList:BG10387" /db_xref="UniProtKB/Swiss-Prot:P07870" /translation="MKIRILCMFICTLLLSGCWDSENIEELSLVIGIGLDKPDDENLE LTQQILVPKIISAKEGSSSDPTQLSITKGKTVHQMMRTSALKHKPTFSQHLRLILLSK SVIADQIGMDAIINQFVRDNGTRRSSYVFITNGRTKDIFNMNDEGEPASNVIYDLTEN NKVTIRTMEPVTLGEISEHLTSDDSFLIPHVGKENGKLAINGASIIKNKLWHRDLTPI EVQNISLFSGTVEGGVIDLKRDGHLFSYEVYSSNRKIKTAYKDGKFKFTVTRNIEGRL SEDWNPNEDSFKDSYIKSIEKTVEKRVHETVTSFITEKLQKEIKADVTGLGNEVRIHY PQKWKKISRKWDDDYFSNAEIDYRVNVIVRDFGTKGANK*" /label="gerAC CDS" gene 3044407..3045528 /gene="gerAC" /locus_tag="BSU_33070" /old_locus_tag="BSU33070" /label="gerAC gene" CDS complement(3045536..3046171) /gene="liaR" /locus_tag="BSU_33080" /old_locus_tag="BSU33080" /function="16.6: Maintain" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11717295, 15273097, 16816187, 17660417, 17921301, 23279150, 23326432, 24666271" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15273097, 16816187, 17660417, 17921301, 23279150, 23326432, 24666271; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YvqE] responding to cell wall stress" /protein_id="NP_391188.1" /db_xref="EnsemblGenomes-Gn:BSU33080" /db_xref="EnsemblGenomes-Tr:CAB15298" /db_xref="GOA:O32197" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG14133" /db_xref="UniProtKB/Swiss-Prot:O32197" /translation="MIRVLLIDDHEMVRMGLAAFLEAQPDIEVIGEASDGSEGVRLAV ELSPDVILMDLVMEGMDGIEATKQICRELSDPKIIVLTSFIDDDKVYPVIEAGALSYL LKTSKAAEIADAIRAASKGEPKLESKVAGKVLSRLRHSGENALPHESLTKRELEILCL IAEGKTNKEIGEELFITIKTVKTHITNILSKLDVSDRTQAAVYAHRNHLVN*" /label="liaR CDS" gene complement(3045536..3046171) /gene="liaR" /locus_tag="BSU_33080" /old_locus_tag="BSU33080" /label="liaR gene" CDS complement(3046149..3047231) /gene="liaS" /locus_tag="BSU_33090" /old_locus_tag="BSU33090" /function="16.12: Sense" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11717295, 15273097, 16816187, 17660417, 17921301, 23279150, 23326432, 24666271" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15273097, 16816187, 17660417, 17921301, 23279150, 23326432, 24666271; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [LiaR(YvqC)] sensing cell wall stress" /protein_id="NP_391189.1" /db_xref="EnsemblGenomes-Gn:BSU33090" /db_xref="EnsemblGenomes-Tr:CAB15299" /db_xref="GOA:O32198" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR017202" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG14134" /db_xref="UniProtKB/Swiss-Prot:O32198" /translation="MRKKMLASLQWRAIRMTTGISLLLFVCLISFMMFYYRLDPLVLL SSSWFGIPFILILLLISVTVGFASGYMYGNRLKTRIDTLIESILTFENGNFAYRIPPL GDDEIGLAADQLNEMAKRVELQVASLQKLSNERAEWQAQMKKSVISEERQRLARDLHD AVSQQLFAISMMTSAVLEHVKDADDKTVKRIRMVEHMAGEAQNEMRALLLHLRPVTLE GKGLKEGLTELLDEFRKKQPIDIEWDIQDTAISKGVEDHLFRIVQEALSNVFRHSKAS KVTVILGIKNSQLRLKVIDNGKGFKMDQVKASSYGLNSMKERASEIGGVAEVISVEGK GTQIEVKVPIFPEEKGENERDSSIID*" /label="liaS CDS" gene complement(3046149..3047231) /gene="liaS" /locus_tag="BSU_33090" /old_locus_tag="BSU33090" /label="liaS gene" CDS complement(3047228..3047953) /gene="liaF" /locus_tag="BSU_33100" /old_locus_tag="BSU33100" /function="16.6: Maintain" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15273097, 15849754, 16816187, 16850406, 17660417, 17921301, 23279150, 23326432" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15273097, 15849754, 16816187, 16850406, 17660417, 17921301, 23279150, 23326432; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="membrane component associated to the LiaRS two-component system" /protein_id="NP_391190.1" /db_xref="EnsemblGenomes-Gn:BSU33100" /db_xref="EnsemblGenomes-Tr:CAB15300" /db_xref="GOA:O32199" /db_xref="InterPro:IPR016975" /db_xref="InterPro:IPR024425" /db_xref="SubtiList:BG14135" /db_xref="UniProtKB/Swiss-Prot:O32199" /translation="MTKKQLLGLIIALFGISMFLQIIGIGDLLFWPLFFLIAGYFLKK YSRDWLGSVMYIFAAFLFLKNLFSITFNLFGYAFAAFLIYAGYRLIKGKPIFEPNEKQ VNLNKKEHHEPPKDVKHPDMRSFFIGELQMMKQPFDLNDLNVSGFIGDIKIDLSKAMI PEGESTIVISGVIGNVDIYVPSDLEVAVSSAVFIGDINLIGSKKSGLSTKVYAASTDF SESKRRVKVSVSLFIGDVDVKYV*" /label="liaF CDS" gene complement(3047228..3047953) /gene="liaF" /locus_tag="BSU_33100" /old_locus_tag="BSU33100" /label="liaF gene" CDS complement(3047987..3048859) /gene="liaG" /locus_tag="BSU_33110" /old_locus_tag="BSU33110" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:15273097, 16816187, 23326432" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15273097, 16816187, 23326432; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="sensor of antibiotic stress on the cell wall" /protein_id="NP_391191.2" /db_xref="EnsemblGenomes-Gn:BSU33110" /db_xref="EnsemblGenomes-Tr:CAB15301" /db_xref="InterPro:IPR025164" /db_xref="SubtiList:BG14136" /db_xref="UniProtKB/Swiss-Prot:O32200" /translation="MKKMLGKLLITAGILVFFAVVVKDVFAAGLGFINGTEADSASAS PRDIDSMVIESDSKDVRIIAEERSDISAGISGDSGKLFVTENKRKLELTVKEKEFQFL NGFNRSTLIVRLPYDYKGDLAVRTSSGDVSVAGNDHLALSGLNAVSASGNTSVTDVRI QDLKVKASSGDVSISNTVSKTAGIDLASGDANLVHVSGSLDVKMTSGDFNAVLKKVTG PVSVTLTSGDANVSLPQNGSFAVNALSASGDVSSPYSFADKGHKEQHHITGTQGSGRH PIDIKTDSGDLAIR*" /label="liaG CDS" gene complement(3047987..3048859) /gene="liaG" /locus_tag="BSU_33110" /old_locus_tag="BSU33110" /label="liaG gene" promotor_-10 complement(3048878..3048897) /Source="Nicolas_upshift_promotors" /id="U2596" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.992007992007992" /psig="0.999000999001" /xcortree=2136 /SigmaFactorBS="cggaacggggaaggatttgcggtcaagtccttcccttccgca cGTATcaattcgcaagcttTTCCTTTATAATAGAATGAAtgagaaggatgaaaccgaa t" /listShort="liaG, liaF, liaS, liaR, S1275" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3048898) /Source="Nicolas_upshifts" /id="U2596" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.992007992007992" /psig="0.999000999001" /xcortree=2136 /SigmaFactorBS="cggaacggggaaggatttgcggtcaagtccttcccttccgca cGTATcaattcgcaagcttTTCCTTTATAATAGAATGAAtgagaaggatgaaaccgaa t" /listShort="liaG, liaF, liaS, liaR, S1275" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3048912..3048915) /Source="Nicolas_upshift_promotors" /id="U2596" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.992007992007992" /psig="0.999000999001" /xcortree=2136 /SigmaFactorBS="cggaacggggaaggatttgcggtcaagtccttcccttccgca cGTATcaattcgcaagcttTTCCTTTATAATAGAATGAAtgagaaggatgaaaccgaa t" /listShort="liaG, liaF, liaS, liaR, S1275" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3048960..3049637) /gene="liaH" /locus_tag="BSU_33120" /old_locus_tag="BSU33120" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15273097, 16816187, 23874669, 24666271, 28546427" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15273097, 16816187, 23874669, 24666271, 28546427; Product type f: factor" /codon_start=1 /transl_table=11 /product="modulator of liaIHGFSR (yvqIHGFEC) operon expression" /protein_id="NP_391192.1" /db_xref="EnsemblGenomes-Gn:BSU33120" /db_xref="EnsemblGenomes-Tr:CAB15302" /db_xref="GOA:O32201" /db_xref="InterPro:IPR007157" /db_xref="SubtiList:BG14137" /db_xref="UniProtKB/Swiss-Prot:O32201" /translation="MVLKRIRDMFVASVHEGLDKMENPKVMLNQYVRDMESDIAKAKQ TIVKQHTIAYQFKKKYEEAAEVAGKRKNQAQLAFDAGEEELAKKALTEMKYLEGKAAE HKASYEQANSQLADLKEQLAALETKLQDVKDKKQALIARANAAKAKEHMNTTFDKIDS ESAYREFLRIENRIEEMEIRANYSKSAEAGTELTRKEFADDVEAEIEKMRTLSLQKSD QTKAANE*" /label="liaH CDS" gene complement(3048960..3049637) /gene="liaH" /locus_tag="BSU_33120" /old_locus_tag="BSU33120" /label="liaH gene" downshifts complement(3048976) /Source="Nicolas_upshifts" /id="D1710" /incds=0 /nref=2 /ntot=28 /MaxReadThrough="3.84852" /MaxDrop="3.1352" /score="-8.3477012" /energy="-4.5" /TU="U2597" /idTUdmin="U2598" /TUdmin=1243 /isTUend="FALSE" /label="downshifts" CDS complement(3049664..3050044) /gene="liaI" /locus_tag="BSU_33130" /old_locus_tag="BSU33130" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15273097, 15849754, 16816187, 16850406, 22720735, 24666271, 28546427" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15273097, 15849754, 16816187, 16850406, 22720735, 24666271, 28546427; Product type s: structure" /codon_start=1 /transl_table=11 /product="membrane anchor for the phage-shock protein A homolog LiaH" /protein_id="NP_391193.1" /db_xref="EnsemblGenomes-Gn:BSU33130" /db_xref="EnsemblGenomes-Tr:CAB15303" /db_xref="GOA:O32202" /db_xref="SubtiList:BG14138" /db_xref="UniProtKB/Swiss-Prot:O32202" /translation="MKINKKTIGGFLLIVFGISVFFGGGSFGFIIPLAIGSLMTYAGI KRFAAGKTITGIIVGGIGAIMLICSLPFVVGIALAAAMVYYGWKLMKNGSADNGVSSF DPEPASAAYQSHFDDEWEEFLKKK*" /label="liaI CDS" gene complement(3049664..3050044) /gene="liaI" /locus_tag="BSU_33130" /old_locus_tag="BSU33130" /label="liaI gene" promotor_-10 complement(3050067..3050086) /Source="Nicolas_upshift_promotors" /id="U2597" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig="0.91008991008991" /xcortree=648 /SigmaFactorBS="cgagatacgactccggtcttatataaaaatcaatctctgatt cGTTTtgcatatcttccaaCTTGTATAAGATGAAGACAAggaaaacgaaaggaggatc t" /listShort="liaI, liaH, liaG, liaF, liaS, liaR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3050087) /Source="Nicolas_upshifts" /id="U2597" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig="0.91008991008991" /xcortree=648 /SigmaFactorBS="cgagatacgactccggtcttatataaaaatcaatctctgatt cGTTTtgcatatcttccaaCTTGTATAAGATGAAGACAAggaaaacgaaaggaggatc t" /listShort="liaI, liaH, liaG, liaF, liaS, liaR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3050101..3050104) /Source="Nicolas_upshift_promotors" /id="U2597" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.672327672327672" /psig="0.91008991008991" /xcortree=648 /SigmaFactorBS="cgagatacgactccggtcttatataaaaatcaatctctgatt cGTTTtgcatatcttccaaCTTGTATAAGATGAAGACAAggaaaacgaaaggaggatc t" /listShort="liaI, liaH, liaG, liaF, liaS, liaR" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3050206..3051474) /gene="yvqJ" /locus_tag="BSU_33140" /old_locus_tag="BSU33140" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15273097, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux protein" /protein_id="NP_391194.1" /db_xref="EnsemblGenomes-Gn:BSU33140" /db_xref="EnsemblGenomes-Tr:CAB15304" /db_xref="GOA:O32203" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG14139" /db_xref="UniProtKB/Swiss-Prot:O32203" /translation="MVNLIESDSIWKRNFNYLFFSRIVKISGDMFAFNSILWFLIYDG KGAIGTALLIAVTFLPEAVLAPVTGPFMKQTTLKFWMYFSDLTRAAIVLIIPLCHFAG FSPLWFVMTLMIVHSATGAAYNPASIALIPQIVNEQGIQKANAVLQSSAQIVRLGAVT LCGAFLTFISPSYTMLIALVLYLVSGFLVLFIKYTAVESQSESAVVTQRGTYIGRLKR GFRLVRKHQILYPLAIYCIFMNFAAAPWEALSAVYVAEDLNGQPIVYSLLKATTAAGA FLLGFVLAKVKVNRYGLLFVTAGIIEGFAFFITGMNTFLPLVFFAAFTFGAAVSAVNV PEYTIIQTSVDSEDQPQVYAVIHMISNISIPAGAVICGYAANAFGSGKVIAVGGIVEI IAGIGILLFTKLAKAERSDLIKEREASVHL*" /label="yvqJ CDS" gene complement(3050206..3051474) /gene="yvqJ" /locus_tag="BSU_33140" /old_locus_tag="BSU33140" /label="yvqJ gene" downshifts complement(3050219) /Source="Nicolas_upshifts" /id="D1711" /incds=0 /nref=78 /ntot=164 /MaxReadThrough="0.70612" /MaxDrop="4.80625" /score="32.7496145" /energy="-12.9" /TU="NA" /idTUdmin="U2598" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3051508..3051527) /Source="Nicolas_upshift_promotors" /id="U2598" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=482 /SigmaFactorBS="attttacgacaaaaaatgaaccttatgaatTATTGACTgaaa aatggaaaaaTGAGATATTGTAATAAATAGatgtaaaaaataggcaacggggggctct g" /listShort="yvqJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3051519) /Source="Nicolas_upshifts" /id="U2598" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=482 /SigmaFactorBS="attttacgacaaaaaatgaaccttatgaatTATTGACTgaaa aatggaaaaaTGAGATATTGTAATAAATAGatgtaaaaaataggcaacggggggctct g" /listShort="yvqJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3051542..3051549) /Source="Nicolas_upshift_promotors" /id="U2598" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=482 /SigmaFactorBS="attttacgacaaaaaatgaaccttatgaatTATTGACTgaaa aatggaaaaaTGAGATATTGTAATAAATAGatgtaaaaaataggcaacggggggctct g" /listShort="yvqJ" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3051645) /Source="Nicolas_upshifts" /id="D1712" /incds=0 /nref=33 /ntot=211 /MaxReadThrough="1.54601" /MaxDrop="4.92923" /score="51.1311697" /energy="-17.1" /TU="NA" /idTUdmin="U2599" /TUdmin=4 /isTUend="TRUE" /label="downshifts" CDS complement(3051651..3052232) /gene="yvqK" /locus_tag="BSU_33150" /old_locus_tag="BSU33150" /EC_number="2.5.1.17" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12869542, 14704351, 17588214, 19933577, 21514283; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ATP:cob(I)alamin adenosyltransferase" /protein_id="NP_391195.2" /db_xref="EnsemblGenomes-Gn:BSU33150" /db_xref="EnsemblGenomes-Tr:CAB15305" /db_xref="GOA:O34899" /db_xref="InterPro:IPR016030" /db_xref="InterPro:IPR029499" /db_xref="InterPro:IPR036451" /db_xref="PDB:1RTY" /db_xref="SubtiList:BG14140" /db_xref="UniProtKB/Swiss-Prot:O34899" /translation="MKLYTKTGDKGQTGLVGGRTDKDSLRVESYGTIDELNSFIGLAL AELSGQPGFEDLTAELLTIQHELFDCGGDLAIVTERKDYKLTEESVSFLETRIDAYTA EAPELKKFILPGGSKCASLLHIARTITRRAERRVVALMKSEEIHETVLRYLNRLSDYF FAAARVVNARSGIGDVEYERSAIVFRDRNSSES*" /label="yvqK CDS" gene complement(3051651..3052232) /gene="yvqK" /locus_tag="BSU_33150" /old_locus_tag="BSU33150" /label="yvqK gene" CDS complement(3052255..3053583) /gene="yvrA" /locus_tag="BSU_33160" /old_locus_tag="BSU33160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14704351; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative vitamin B12 transport system, ATPase component" /protein_id="NP_391196.1" /db_xref="EnsemblGenomes-Gn:BSU33160" /db_xref="EnsemblGenomes-Tr:CAB15306" /db_xref="GOA:O34631" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG14141" /db_xref="UniProtKB/Swiss-Prot:O34631" /translation="MKAEGLSGGYGDSRLINNVSLTVEKGEFLGILGPNGSGKTTLLH LLTGTLPAKKGRVYLAGKLLADYKPKELAQIMAVLPQKMDQAFTFTVEETVAFGRYPF QTGLFRQQTEKGEAIVQEAMEQTGVADFAQKPIRELSGGEQQRVYLAQALAQQPRILF LDEPTNFLDLAYQKDLLDLIKRLTRESGLAAVSVFHDLNTASLYCDGLMFMKNGTAGP KQKPEYAVTEQSIKAVYDTDVTALVHQSSPKPMIVIQPEKDSVKRQSIPFEALLQAGR DDILLQTEIPLRTLSSTPIGAGFSWSRTLIHKRLPDQPDPIEGLTACLSESGFQLQET CAMASSERLDRFVYRTYEDGELSVFICVQTGFSIWILINGYAADQFFIKALMAAEAER TKVLGDGGGTGDILIAATQTQQSENIEQRLNQLIKKGTAECIKEAAELFE*" /label="yvrA CDS" gene complement(3052255..3053583) /gene="yvrA" /locus_tag="BSU_33160" /old_locus_tag="BSU33160" /label="yvrA gene" CDS complement(3053583..3054644) /gene="yvrB" /locus_tag="BSU_33170" /old_locus_tag="BSU33170" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14704351, 15849754, 16850406, 25917914; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative vitamin B12 permease" /protein_id="NP_391197.1" /db_xref="EnsemblGenomes-Gn:BSU33170" /db_xref="EnsemblGenomes-Tr:CAB15307" /db_xref="GOA:O34451" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG14142" /db_xref="UniProtKB/Swiss-Prot:O34451" /translation="MRKAFTRIRLRNNRYAAYIIGFSFLAVSIILGISCGSLHIPIPA VFRVFWHQGFGGSIGSDDPMYTNIMMNIRLPRVVLAALVGAALSIAGAAFQGLLKNPL ADPYTLGVSSGASVGAVVTLFLGLHLPVIGGFTLPVLSVAAALATMAAVLFFSRLVHA SMSVSTLILTGVITNSFLGAFISLIIALTGDNLLPIVHWLLGSVSMRGWSYVILFLPF FLLGTILLIINGRELNVMTYGEDKAKLLGVSVQQRKMMILIAGSLLTGSAVAVSGTIG FVGLVIPHITRLLWGTDHRHLLPLSALLGAGFLVLADLLSRTIIEPIELPIGIITSLA GAPVFALILIRQHRGGRSL*" /label="yvrB CDS" gene complement(3053583..3054644) /gene="yvrB" /locus_tag="BSU_33170" /old_locus_tag="BSU33170" /label="yvrB gene" CDS complement(3054607..3055551) /gene="yvrC" /locus_tag="BSU_33180" /old_locus_tag="BSU33180" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14704351, 25917914; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative lipoprotein binding vitamin B12" /protein_id="NP_391198.1" /db_xref="EnsemblGenomes-Gn:BSU33180" /db_xref="EnsemblGenomes-Tr:CAB15308" /db_xref="GOA:O34805" /db_xref="InterPro:IPR002491" /db_xref="SubtiList:BG14143" /db_xref="UniProtKB/Swiss-Prot:O34805" /translation="MKKRAGIWAALLLAAVMLAGCGNPADQKDSKAKQKTEVFPVTID DASNQDVTIKKEPKKIVSLMPSNTEITYALGLGDKVVGVTTNDTYPKEVKKVEKVGDM NVNVEKVISLKPDLVLAHESSMSASADAIKQLKDAGITVLTVNDAQSFSEVYKSIEMI GEAGGAEKKADQLVKSMKSDLKDIQEKAKTISKDEEKSVFIEVSPDPDIYTTGKDTFM NEMLNVIHAKNAAADQTGWVQMTDEAIVKLNPDAIVTTDGVKAKAVEKRDGWSEINAV KHHRVYDVDPDLVTRSGPRLIEGVEELAESIYPDTFKE*" /label="yvrC CDS" gene complement(3054607..3055551) /gene="yvrC" /locus_tag="BSU_33180" /old_locus_tag="BSU33180" /label="yvrC gene" S_feature complement(3055552..3055821) /Source="Nicolas_S_feature" /locus_tag="new_3404438_3404707_c" /HighExp="LBGtran, LBGexp, Etha, LPh, S3, Lbexp, G180, dia0, HPh, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="0.956, 1" /TUlongSig="SigA" /TUlongPSig="0.925" /label="S1276" misc_RNA complement(3055660..3055790) /gene="srbL" /locus_tag="BSU_misc_RNA_85" /product="putative coenzyme B12 (AdoCbl) riboswitch" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14704351, 17038623, 21140903, 25917914; Product type n: RNA" /function="16.3: Control" /label="srbL RNA" gene complement(3055660..3055790) /gene="srbL" /locus_tag="BSU_misc_RNA_85" /label="srbL gene" promotor_-10 complement(3055798..3055817) /Source="Nicolas_upshift_promotors" /id="U2599" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.899100899100899" /psig="0.956043956043956" /xcortree=2215 /SigmaFactorBS="tttgcttccatacacaatatggggaaaagtcattcaggacaC ATATACAagcctgtcagtcataTAGTATAATTACTCCGAAAAacggatacgaatgtca a" /listShort="S1276, yvrC, yvrB, yvrA, yvqK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3055821) /Source="Nicolas_upshifts" /id="U2599" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.899100899100899" /psig="0.956043956043956" /xcortree=2215 /SigmaFactorBS="tttgcttccatacacaatatggggaaaagtcattcaggacaC ATATACAagcctgtcagtcataTAGTATAATTACTCCGAAAAacggatacgaatgtca a" /listShort="S1276, yvrC, yvrB, yvrA, yvqK" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3055823..3056750) /Source="Nicolas_S_feature" /locus_tag="new_3404709_3405636_c" /HighExp="Etha, B60, Sw, M9-stat, B36, C30, C90, Salt, G135, Gly" /AntisenseName="yvrD" /AntisenseCor="1.5286196477289399E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.925" /label="S1277" promotor_-35 complement(3055833..3055840) /Source="Nicolas_upshift_promotors" /id="U2599" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.899100899100899" /psig="0.956043956043956" /xcortree=2215 /SigmaFactorBS="tttgcttccatacacaatatggggaaaagtcattcaggacaC ATATACAagcctgtcagtcataTAGTATAATTACTCCGAAAAacggatacgaatgtca a" /listShort="S1276, yvrC, yvrB, yvrA, yvqK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3055883..3055890 /Source="Nicolas_upshift_promotors" /id="U2600" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.868131868131868" /psig="0.992007992007992" /xcortree=1946 /SigmaFactorBS="atgacttttccccatattgtgtatggaagcaaaaTCCTCGTA aacactaaatttgaTCTTGTATACTTAATACCATcatctatcaaaaggaatgattctt a" /listShort="yvrD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3055905..3055924 /Source="Nicolas_upshift_promotors" /id="U2600" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.868131868131868" /psig="0.992007992007992" /xcortree=1946 /SigmaFactorBS="atgacttttccccatattgtgtatggaagcaaaaTCCTCGTA aacactaaatttgaTCTTGTATACTTAATACCATcatctatcaaaaggaatgattctt a" /listShort="yvrD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3055909 /Source="Nicolas_upshifts" /id="U2600" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.868131868131868" /psig="0.992007992007992" /xcortree=1946 /SigmaFactorBS="atgacttttccccatattgtgtatggaagcaaaaTCCTCGTA aacactaaatttgaTCTTGTATACTTAATACCATcatctatcaaaaggaatgattctt a" /listShort="yvrD" /GFF_Attribute="listLong" /label="upshifts" CDS 3055949..3056740 /gene="yvrD" /locus_tag="BSU_33190" /old_locus_tag="BSU33190" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9922248; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391199.1" /db_xref="EnsemblGenomes-Gn:BSU33190" /db_xref="EnsemblGenomes-Tr:CAB15309" /db_xref="GOA:O34782" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG14144" /db_xref="UniProtKB/Swiss-Prot:O34782" /translation="MDLQLKEKLVLITGSTSGIGKAAAKSFLQEGAAVIVNGRKQETV DRTIEELSGYGTVHGAAADLSKTDEAAAFIEKVNEIGDIDILVNNLGFFEVKDFADVT DEEWNQYFEVNVMSAVRTSRHFLPKMLAKNSGRILNIASEAGVKPLPTMIPYSMTKTA LISLSRGMAEMTKGTNVTVNSVLPGPTWTEGVASYMEGAAQAAGQDTDTFIKDYFKVN EPTSLIQRYATAEEVANTIVFLASDAASAINGTAQRVEGGIIRSL*" /label="yvrD CDS" gene 3055949..3056740 /gene="yvrD" /locus_tag="BSU_33190" /old_locus_tag="BSU33190" /label="yvrD gene" downshifts 3056611 /Source="Nicolas_upshifts" /id="D1713" /incds=1 /nref=2 /ntot=89 /MaxReadThrough="6.202" /MaxDrop="3.35017" /score="36.8938178" /energy="-12" /TU="U2600" /idTUdmin="U2600" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" downshifts 3056721 /Source="Nicolas_upshifts" /id="D1714" /incds=0 /nref=105 /ntot=218 /MaxReadThrough="2.44739" /MaxDrop="6.33457" /score="36.8938178" /energy="-12" /TU="NA" /idTUdmin="U2600" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3056778..3057656) /gene="yvrE" /locus_tag="BSU_33200" /old_locus_tag="BSU33200" /EC_number="3.1.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sugar lactone lactonase" /protein_id="NP_391200.1" /db_xref="EnsemblGenomes-Gn:BSU33200" /db_xref="EnsemblGenomes-Tr:CAB15310" /db_xref="GOA:O34940" /db_xref="InterPro:IPR005511" /db_xref="InterPro:IPR011042" /db_xref="InterPro:IPR013658" /db_xref="SubtiList:BG14145" /db_xref="UniProtKB/Swiss-Prot:O34940" /translation="MDAVLEADTRAVIGEGPLWDEENGRLYWVDILGSELHIFDPEEK INRSIKFKSFVTALAKYSKDELIMTMKDGFYLYHLRDDSLEKIKQPKDMHESLRFNDA KCDPYGRLWAGTTSMEGEQKQASLYRLNLDGSLVKIKDQVSTSNGLDWDRERNLMYYI DTPTQEIVRYSYDPQSGDVSNPEPVYRFDQSDGLPDGMTIDQNGMLWVALFGGSRVVH IDPFQKKEINSISVPAKYVTCCAFGGRDLKTLYITTATEQMTEKERYEQPHAGGLFSA QLETGGYQPVPFAGDV*" /label="yvrE CDS" gene complement(3056778..3057656) /gene="yvrE" /locus_tag="BSU_33200" /old_locus_tag="BSU33200" /label="yvrE gene" downshifts complement(3056795) /Source="Nicolas_upshifts" /id="D1715" /incds=0 /nref=31 /ntot=260 /MaxReadThrough="7.17016" /MaxDrop="5.74101" /score="29.8014794" /energy="-12" /TU="U2601" /idTUdmin="U2602" /TUdmin="-20" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3057680..3057698) /Source="Nicolas_upshift_promotors" /id="U2601" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=160 /SigmaFactorBS="cggtcattaccatcctttttaaaaaacaataaacatcaagtG GTTTGGacacctctttgccGGGAATAACAATATATAGActgaagctaaagaggtgtaa c" /listShort="yvrE, S1277, S1276, yvrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3057699) /Source="Nicolas_upshifts" /id="U2601" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=160 /SigmaFactorBS="cggtcattaccatcctttttaaaaaacaataaacatcaagtG GTTTGGacacctctttgccGGGAATAACAATATATAGActgaagctaaagaggtgtaa c" /listShort="yvrE, S1277, S1276, yvrC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3057712..3057718) /Source="Nicolas_upshift_promotors" /id="U2601" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=160 /SigmaFactorBS="cggtcattaccatcctttttaaaaaacaataaacatcaagtG GTTTGGacacctctttgccGGGAATAACAATATATAGActgaagctaaagaggtgtaa c" /listShort="yvrE, S1277, S1276, yvrC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3057728..3059470) /gene="yvrG" /locus_tag="BSU_33210" /old_locus_tag="BSU33210" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295, 16306698, 25879813" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 16306698, 25879813; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase YvrG [cellwall processes and sublancin production and immunity(YvrH)]" /protein_id="NP_391201.2" /db_xref="EnsemblGenomes-Gn:BSU33210" /db_xref="EnsemblGenomes-Tr:CAB15311" /db_xref="GOA:O34989" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG14146" /db_xref="UniProtKB/Swiss-Prot:O34989" /translation="MRLRWKFLFHFFGQMLIVILLLTVMLVASFFYLDARFSDAESNS GLTKATTDTLEAYLDVNEDGTWEVDNFLKKSVDKQHGWMQIIDSEGNTDYSYGVPKDV PGTYTKKELLSIYKTKKLHNYKLNYWAINIEDKSYLLLSGWKSKSEQLLTSVEKREQK IDSLAHYKSSTIDYIKRKKGAIYLLDSNGKILDSINSTKSERKTMNQLELLKYSSKPW NYKREISVKILNKDRWMVATVPNPVYVTDQEFNKSFLKVVLKAMFLVMAVLFMYIIWM TVWYMFRFGLPIFHTIRWLVNLSKGKLEEPRNREGRPVSKNKKGKIKQPYRFFGEIFE SMDQLTETLRRDKRNREKIQATREEWIAGLSHDLKTPLSSIYGYSMMLESKQYDWSPE EVKEMGQVVREKSEYMSKLIEDLNLTYRLKNDALPIERKLTSLIPFFKNVIEDFKKNP FSEGYDISFVSKEEHIEFALDEAWFRRILENLLGNAVKHNGKGTEIQVILEQTKNHIS LKVKDNGKGMDEETITHLFNRYYRGTNTKDSTAGTGLGLAIAKELVHLHNGTIHVNSR TNIGTVITILFKKQ*" /label="yvrG CDS" gene complement(3057728..3059470) /gene="yvrG" /locus_tag="BSU_33210" /old_locus_tag="BSU33210" /label="yvrG gene" CDS complement(3059467..3060180) /gene="yvrH" /locus_tag="BSU_33221" /old_locus_tag="BSU33221" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 16306698, 25879813" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 16306698, 25879813; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase YvrG [cellwall processes and sublancin production and immunity(YvrG)]" /protein_id="NP_391202.2" /db_xref="EnsemblGenomes-Gn:BSU33221" /db_xref="EnsemblGenomes-Tr:CAB15312" /db_xref="GOA:P94504" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12452" /db_xref="UniProtKB/Swiss-Prot:P94504" /translation="MENASILIVDDEKAIVDMIKRVLEKEGYRNILDAASAEEAIPVV KANKVDLIVLDVMMGGMSGFEACTLIREYSDAPIFFLTARSSDADKLSGFAVGADDYI TKPFNPLELAARIRAHLKRTYQSKETSSNQTYTYDYFTFSPQNAELIVGGEAVACSAQ LLQLLQYFCEHPNVVLSKDQIYEKVWGYPSYGDNNTVMVHIRKLREKIERDPSNPEYI VTVRGLGYRFIPNPEGKRS*" /label="yvrH CDS" gene complement(3059467..3060180) /gene="yvrH" /locus_tag="BSU_33221" /old_locus_tag="BSU33221" /label="yvrH gene" misc_feature complement(3060211..3060230) /Source="Nicolas_upshift_promotors" /id="U2602" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.629370629370629" /psig="0.925074925074925" /xcortree=2348 /SigmaFactorBS="ccttttttgctgttttgatttgccaaggctccaatgtattca aaaatgtaccataaataAACGATATAATGATAAGATGaaaaaaacagtgacagaaagg a" /listShort="yvrH, yvrG, yvrE" /listLong="S1277, S1276, yvrC" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3060229) /Source="Nicolas_upshifts" /id="U2602" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.629370629370629" /psig="0.925074925074925" /xcortree=2348 /SigmaFactorBS="ccttttttgctgttttgatttgccaaggctccaatgtattca aaaatgtaccataaataAACGATATAATGATAAGATGaaaaaaacagtgacagaaagg a" /listShort="yvrH, yvrG, yvrE" /listLong="S1277, S1276, yvrC" /label="upshifts" CDS complement(3060333..3060572) /gene="rsoA" /locus_tag="BSU_33222" /old_locus_tag="BSU33222" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:18573182, 19047353, 27558998" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18573182, 19047353, 27558998; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of sigma-O" /protein_id="YP_003097787.1" /db_xref="EnsemblGenomes-Gn:BSU33222" /db_xref="EnsemblGenomes-Tr:CAX52693" /db_xref="GOA:C0H3R4" /db_xref="UniProtKB/Swiss-Prot:C0H3R4" /translation="MDGQFEQKKKQKDETYDIEHLIACFSPMIRKKLSNTSYQEREDL EQELKIKMFEKADMLLCQDVPGFWEFILYMVDENS*" /label="rsoA CDS" gene complement(3060333..3060572) /gene="rsoA" /locus_tag="BSU_33222" /old_locus_tag="BSU33222" /label="rsoA gene" downshifts complement(3060340) /Source="Nicolas_upshifts" /id="D1716" /incds=0 /nref=4 /ntot=30 /MaxReadThrough="2.45068" /MaxDrop="3.82244" /score="12.6471586" /energy="-8.2" /TU="NA" /idTUdmin="U2605" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3060568..3060586) /Source="Nicolas_upshift_promotors" /id="U2603" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=142 /SigmaFactorBS="ataaaaaggggctggagaatatcagaaagcAGTTAGCggcgc aaaaaaaggGGGAAAAGTAAGCTGTGGAcggccagtttgaacaaaaaaagaaacaaaa a" /listShort="rsoA" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(3060576..3061106) /gene="sigO" /locus_tag="BSU_33230" /old_locus_tag="BSU33230" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16306698, 18573182, 19047353, 27558998" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16306698, 18573182, 19047353, 27558998; Product type r: regulator" /codon_start=1 /transl_table=11 /product="alternative sigma factor" /protein_id="NP_391203.2" /db_xref="EnsemblGenomes-Gn:BSU33230" /db_xref="EnsemblGenomes-Tr:CAB15313" /db_xref="GOA:O34843" /db_xref="InterPro:IPR007630" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG14147" /db_xref="UniProtKB/Swiss-Prot:O34843" /translation="MKHPIVKHFLSNPQHYRLFKNVMESPNEKDARSLDELFKQFYKE IRIVKYMNSMIRIFSIDFDKRVRKNQKRYPLTVDHPEAGDRLSSETGSDAFEEFLDRQ DDLSQHVQDYQLYQAIQKLTDKQKSVLTKVYLHGATMQEIADSLGESRQNISNIHKKG LENIRKQLAAQKKGEK*" /label="sigO CDS" gene complement(3060576..3061106) /gene="sigO" /locus_tag="BSU_33230" /old_locus_tag="BSU33230" /label="sigO gene" upshifts complement(3060577) /Source="Nicolas_upshifts" /id="U2603" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=142 /SigmaFactorBS="ataaaaaggggctggagaatatcagaaagcAGTTAGCggcgc aaaaaaaggGGGAAAAGTAAGCTGTGGAcggccagtttgaacaaaaaaagaaacaaaa a" /listShort="rsoA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3060601..3060607) /Source="Nicolas_upshift_promotors" /id="U2603" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=142 /SigmaFactorBS="ataaaaaggggctggagaatatcagaaagcAGTTAGCggcgc aaaaaaaggGGGAAAAGTAAGCTGTGGAcggccagtttgaacaaaaaaagaaacaaaa a" /listShort="rsoA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3061109..3061128) /Source="Nicolas_upshift_promotors" /id="U2604" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=2005 /SigmaFactorBS="tcatttaatttagtagggaggcggttTGATGGACtatcaaag tcttttACGGTCAAAATGTAAGGAGAtaatgaagcatcccatcgtgaagcattttttg a" /listShort="sigO, rsoA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3061116) /Source="Nicolas_upshifts" /id="U2604" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=2005 /SigmaFactorBS="tcatttaatttagtagggaggcggttTGATGGACtatcaaag tcttttACGGTCAAAATGTAAGGAGAtaatgaagcatcccatcgtgaagcattttttg a" /listShort="sigO, rsoA" /GFF_Attribute="listLong" /label="upshifts" CDS 3061121..3061459 /gene="yvrJ" /locus_tag="BSU_33239" /old_locus_tag="BSU33239" /experiment="publication(s) with functional evidences, PMID:18573182, 19047353" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18573182, 19047353; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor involved in oxalate decarboxylase expression" /protein_id="YP_003097788.1" /db_xref="EnsemblGenomes-Gn:BSU33239" /db_xref="EnsemblGenomes-Tr:CAX52694" /db_xref="InterPro:IPR024419" /db_xref="UniProtKB/Swiss-Prot:C0H3R5" /translation="MTVKDFDSPSNRLPTKLNEGKQKKVNYYFPPSVFQNTLQQFTFY RFSSLTYMTAEKEGRYFPMDQVFIEEVVKQIGNLGFPALIAMYLLTRFEKKFDQLIEL MTELKDHAKK*" /label="yvrJ CDS" gene 3061121..3061459 /gene="yvrJ" /locus_tag="BSU_33239" /old_locus_tag="BSU33239" /label="yvrJ gene" promotor_-35 complement(3061143..3061150) /Source="Nicolas_upshift_promotors" /id="U2604" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.974025974025974" /psig=1 /xcortree=2005 /SigmaFactorBS="tcatttaatttagtagggaggcggttTGATGGACtatcaaag tcttttACGGTCAAAATGTAAGGAGAtaatgaagcatcccatcgtgaagcattttttg a" /listShort="sigO, rsoA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3061159..3061178) /Source="Nicolas_upshift_promotors" /id="U2605" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.276723276723277" /psig="0.538461538461538" /xcortree=388 /SigmaFactorBS="agtattttggaagacactaggcggaaagtagtAGTTTACttt tttttgctttcCTTCATTTAATTTAGTAGGGaggcggtttgatggactatcaaagtct t" /listShort="sigO, rsoA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3061171) /Source="Nicolas_upshifts" /id="U2605" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.276723276723277" /psig="0.538461538461538" /xcortree=388 /SigmaFactorBS="agtattttggaagacactaggcggaaagtagtAGTTTACttt tttttgctttcCTTCATTTAATTTAGTAGGGaggcggtttgatggactatcaaagtct t" /listShort="sigO, rsoA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3061193..3061199) /Source="Nicolas_upshift_promotors" /id="U2605" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.276723276723277" /psig="0.538461538461538" /xcortree=388 /SigmaFactorBS="agtattttggaagacactaggcggaaagtagtAGTTTACttt tttttgctttcCTTCATTTAATTTAGTAGGGaggcggtttgatggactatcaaagtct t" /listShort="sigO, rsoA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_no_box 3061205..3061305 /Source="Nicolas_upshift_promotors" /id="U2606" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.3996003996004" /psig="0.277722277722278" /xcortree=389 /SigmaFactorBS="tttccgcctagtgtcttccaaaatactttgcagcagtttacg ttttatcggttttcctcacttacatacatgactgcagaaaaagaagggaggtattttc c" /GFF_Attribute="listShort" /listLong="S1278, oxdC, yvrL" /label="promotor_no_box" upshifts 3061265 /Source="Nicolas_upshifts" /id="U2606" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.3996003996004" /psig="0.277722277722278" /xcortree=389 /SigmaFactorBS="tttccgcctagtgtcttccaaaatactttgcagcagtttacg ttttatcggttttcctcacttacatacatgactgcagaaaaagaagggaggtattttc c" /GFF_Attribute="listShort" /listLong="S1278, oxdC, yvrL" /label="upshifts" promotor_no_box 3061433..3061533 /Source="Nicolas_upshift_promotors" /id="U2607" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.405594405594406" /psig="0.316683316683317" /xcortree=387 /SigmaFactorBS="gaactgaaagatcatgcaaaaaaataatttttcaatcgaagt tgacttttcactggtttttttcacttaacaaaacagaagggaaaacgaaaggcctttc a" /listShort="S1278, oxdC, yvrL" /GFF_Attribute="listLong" /label="promotor_no_box" S_feature 3061493..3061579 /Source="Nicolas_S_feature" /locus_tag="new_3410379_3410465" /HighExp="T5.0H, T4.0H, T3.30H, Lbstat, T3.0H, nit, T2.0H, T2.30H, LPhT, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.317" /TUlongSig="Sig-" /TUlongPSig="0.278" /label="S1278" upshifts 3061493 /Source="Nicolas_upshifts" /id="U2607" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.405594405594406" /psig="0.316683316683317" /xcortree=387 /SigmaFactorBS="gaactgaaagatcatgcaaaaaaataatttttcaatcgaagt tgacttttcactggtttttttcacttaacaaaacagaagggaaaacgaaaggcctttc a" /listShort="S1278, oxdC, yvrL" /GFF_Attribute="listLong" /label="upshifts" CDS 3061580..3062737 /gene="oxdC" /locus_tag="BSU_33240" /old_locus_tag="BSU33240" /EC_number="4.1.1.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10960116, 14697267, 14871895, 17459326, 18573182, 19047353, 21255608, 21264418, 21782782, 26744902, 27797181" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10960116, 14697267, 14871895, 17459326, 18573182, 19047353, 21255608, 21264418, 21782782, 26744902, 27797181; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="oxalate decarboxylase" /protein_id="NP_391204.1" /db_xref="EnsemblGenomes-Gn:BSU33240" /db_xref="EnsemblGenomes-Tr:CAB15314" /db_xref="GOA:O34714" /db_xref="InterPro:IPR006045" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR017774" /db_xref="PDB:1J58" /db_xref="PDB:1L3J" /db_xref="PDB:1UW8" /db_xref="PDB:2UY8" /db_xref="PDB:2UY9" /db_xref="PDB:2UYA" /db_xref="PDB:2UYB" /db_xref="PDB:2V09" /db_xref="PDB:3S0M" /db_xref="PDB:4MET" /db_xref="PDB:5HI0" /db_xref="SubtiList:BG14148" /db_xref="UniProtKB/Swiss-Prot:O34714" /translation="MKKQNDIPQPIRGDKGATVKIPRNIERDRQNPDMLVPPETDHGT VSNMKFSFSDTHNRLEKGGYAREVTVRELPISENLASVNMRLKPGAIRELHWHKEAEW AYMIYGSARVTIVDEKGRSFIDDVGEGDLWYFPSGLPHSIQALEEGAEFLLVFDDGSF SENSTFQLTDWLAHTPKEVIAANFGVTKEEISNLPGKEKYIFENQLPGSLKDDIVEGP NGEVPYPFTYRLLEQEPIESEGGKVYIADSTNFKVSKTIASALVTVEPGAMRELHWHP NTHEWQYYISGKARMTVFASDGHARTFNYQAGDVGYVPFAMGHYVENIGDEPLVFLEI FKDDHYADVSLNQWLAMLPETFVQAHLDLGKDFTDVLSKEKHPVVKKKCSK*" /label="oxdC CDS" gene 3061580..3062737 /gene="oxdC" /locus_tag="BSU_33240" /old_locus_tag="BSU33240" /label="oxdC gene" downshifts 3062723 /Source="Nicolas_upshifts" /id="D1717" /incds=0 /nref=11 /ntot=87 /MaxReadThrough="4.83038" /MaxDrop="4.39135" /score="2.61432951" /energy="-9.4" /TU="U2607" /idTUdmin="U2607" /TUdmin="-484" /isTUend="FALSE" /label="downshifts" CDS 3062798..3063208 /gene="rsiO" /locus_tag="BSU_33250" /old_locus_tag="BSU33250" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 18573182, 19047353, 26651345" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 18573182, 19047353, 26651345; Product type f: factor" /codon_start=1 /transl_table=11 /product="acid stress-sensitive anti sigma factor" /protein_id="NP_391205.1" /db_xref="EnsemblGenomes-Gn:BSU33250" /db_xref="EnsemblGenomes-Tr:CAB15315" /db_xref="GOA:O34686" /db_xref="InterPro:IPR025912" /db_xref="SubtiList:BG14149" /db_xref="UniProtKB/Swiss-Prot:O34686" /translation="MKHQNPSKRLLRLSIKYLLAAAAVVLTYFAVIYILFSLAGTSYR SAAHVLLFAVVFLVLGLCFEPFERLMIHSFTFFKTGKRLFILLAGIVQLLFLWMTAHT TDQLISDIWLSTTEEMIVAAVFLILDKCNSALPS*" /label="rsiO CDS" gene 3062798..3063208 /gene="rsiO" /locus_tag="BSU_33250" /old_locus_tag="BSU33250" /label="rsiO gene" downshifts 3063207 /Source="Nicolas_upshifts" /id="D1718" /incds=0 /nref=1 /ntot=22 /MaxReadThrough="0.57216" /MaxDrop="3.72691" /score="-9.50136752" /energy="-7.4" /TU="NA" /idTUdmin="U2607" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3063242..3064471) /gene="yvrN" /locus_tag="BSU_33260" /old_locus_tag="BSU33260" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_391207.3" /db_xref="EnsemblGenomes-Gn:BSU33260" /db_xref="EnsemblGenomes-Tr:CAB15317" /db_xref="GOA:P46324" /db_xref="InterPro:IPR003838" /db_xref="InterPro:IPR025857" /db_xref="SubtiList:BG11368" /db_xref="UniProtKB/Swiss-Prot:P46324" /translation="MLEHIRISFQSIFSHKLRSILTMLGVIIGIAAIIAIVSMLKGQS EQLKQSMIGMGNNAINVVYQPSGGEEESGGPQVSYASAPPVAEETVKAIKSDPMVKGL SLYYLSEGASVFHLTNVSYPQVYGVDDDYFDMFPIRITEGRKLTENDLNSTHQVVMIN EAVRDELFPDGEALHKSIEMNGVPFKVVGVFKEKNQQESMFEGDYANPVLYVPKKVWP LIEGFDAPTQIAVQADSSEHIQEAGVMAADLLNQGLSEAELEKAEYSVMDLQEIAQEV ESFNQSFALLLGGIASISLLVGGIGVMNIMLVSVTERTREIGIKKALGAKRRVILFQF LTEAVVLTSIGGILGVLAGFGIAKLLTVIFPMPFIVSIPAVVGALIFSMAVGIIFGLL PSIKASKLQPVDALRYE*" /label="yvrN CDS" gene complement(3063242..3064471) /gene="yvrN" /locus_tag="BSU_33260" /old_locus_tag="BSU33260" /label="yvrN gene" downshifts complement(3063259) /Source="Nicolas_upshifts" /id="D1719" /incds=0 /nref=10 /ntot=218 /MaxReadThrough="2.36812" /MaxDrop="4.29282" /score="13.74435" /energy="-11.3" /TU="NA" /idTUdmin="U2608" /TUdmin="-20" /isTUend="TRUE" /label="downshifts" CDS complement(3064464..3065153) /gene="yvrO" /locus_tag="BSU_33270" /old_locus_tag="BSU33270" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11544226, 22517742; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_391208.2" /db_xref="EnsemblGenomes-Gn:BSU33270" /db_xref="EnsemblGenomes-Tr:CAB15318" /db_xref="GOA:O34979" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG14151" /db_xref="UniProtKB/Swiss-Prot:O34979" /translation="MLTLNNISKSYKLGKEEVPILKHINLTVQAGEFLAIMGPSGSGK STLMNIIGCLDRPTSGTYTLDQIDILKGKDGALAEIRNESIGFVFQTFHLLPRLTALQ NVELPMIYNKVKKKERRQRAYEALEKVGLKDRVSYKPPKLSGGQKQRVAIARALVNQP RFILADEPTGALDTKSSEQILALFSELHREGKTIIMITHDPDVAKKADRTVFIRDGEL VLDERGDISHA*" /label="yvrO CDS" gene complement(3064464..3065153) /gene="yvrO" /locus_tag="BSU_33270" /old_locus_tag="BSU33270" /label="yvrO gene" CDS complement(3065137..3066330) /gene="yvrP" /locus_tag="BSU_33280" /old_locus_tag="BSU33280" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter membrane fusion component" /protein_id="NP_391209.1" /db_xref="EnsemblGenomes-Gn:BSU33280" /db_xref="EnsemblGenomes-Tr:CAB15319" /db_xref="GOA:O35007" /db_xref="InterPro:IPR032317" /db_xref="SubtiList:BG14152" /db_xref="UniProtKB/Swiss-Prot:O35007" /translation="MSKKKKWLIGGAICAGVLVLAGIGAGGFYFFTHMNQVAVSSEPY AESVAVYMGGDSESGQTFSGKVEPEKQQKVYIDSEKGSIKKTYVKEGDQVKKGDKLFE YEGEDHSDEVEQANLQIEMTNLQINRLQKSITETEKKLKVAGKEEKNQLQDELDQTNF DLKTSQLELKQHQKELAGLTKNKGSNVITSKHDGIVQSVNQDIADGATGDQAAGPYIQ IVSTGKYLVKSQINELLMDTIKKGSKVRVTLKTGGEGEWKGKVTSIGKLPAGAGEGEE SESFADEEMNPQSSNYPFTILLDSHKGLEVGYHVNIEVMSDNADADTIKLPSDMVIQD DGEPYVWKADENHKAVKQPVEIGETDENDMVEIKSGLTPEDYVIYPDPAVKEGKQVTV NADTE*" /label="yvrP CDS" gene complement(3065137..3066330) /gene="yvrP" /locus_tag="BSU_33280" /old_locus_tag="BSU33280" /label="yvrP gene" promotor_-10 complement(3066374..3066393) /Source="Nicolas_upshift_promotors" /id="U2608" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=2297 /SigmaFactorBS="ttttctatttgattccgtcatttcaataaaagGATTGCAAgt ctttttgaattaATAGATAATATTGGTTAGAAtgtttcgaaaatattacatagtttac a" /listShort="yvrP, yvrO, yvrN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3066387) /Source="Nicolas_upshifts" /id="U2608" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=2297 /SigmaFactorBS="ttttctatttgattccgtcatttcaataaaagGATTGCAAgt ctttttgaattaATAGATAATATTGGTTAGAAtgtttcgaaaatattacatagtttac a" /listShort="yvrP, yvrO, yvrN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3066408..3066415) /Source="Nicolas_upshift_promotors" /id="U2608" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=2297 /SigmaFactorBS="ttttctatttgattccgtcatttcaataaaagGATTGCAAgt ctttttgaattaATAGATAATATTGGTTAGAAtgtttcgaaaatattacatagtttac a" /listShort="yvrP, yvrO, yvrN" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3066501..3067310) /gene="fhuC" /locus_tag="BSU_33290" /old_locus_tag="BSU33290" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8388528, 8596459, 10913070, 15802251; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ferrichrome ABC transporter (ATP-binding protein)" /protein_id="NP_391210.1" /db_xref="EnsemblGenomes-Gn:BSU33290" /db_xref="EnsemblGenomes-Tr:CAB15335" /db_xref="GOA:P49938" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11390" /db_xref="UniProtKB/Swiss-Prot:P49938" /translation="MNSLSTEQLGIGYGDRVIVEDLNISIPKGKITTLIGPNGCGKST ILKTMSRIMRSHAGAVYLNGKAIHKMSTKDIAKDMAILPQTPEAPSGLTVHELVSYGR FPHQSGFGRLNDEDRRIIKWALEETGMAEYAERPIEALSGGQRQRVWIAMALAQGTEL LLLDEPTTYLDLAHQLEILQLLDRLNKEQGRTILMVIHDLNHAARFSHYMIALKKGTV IKEGTALEVMTPDILKQVFQIDAEIVTDPRTNKPVCLTYDLIKNEKELVTV*" /label="fhuC CDS" gene complement(3066501..3067310) /gene="fhuC" /locus_tag="BSU_33290" /old_locus_tag="BSU33290" /label="fhuC gene" downshifts complement(3066518) /Source="Nicolas_upshifts" /id="D1720" /incds=0 /nref=190 /ntot=245 /MaxReadThrough="1.31294" /MaxDrop="6.48454" /score="40.5986253" /energy="-11" /TU="NA" /idTUdmin="U2610" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 3066657..3066666 /Source="Nicolas_upshift_promotors" /id="U2609" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1247 /SigmaFactorBS="gtgtcatgacctccagagcagttccttccttgatGACCGTGC CTtttttgagcgcgATCATATAATGAGAAAAACGagctgcatggttaagatcatgaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3066679..3066698 /Source="Nicolas_upshift_promotors" /id="U2609" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1247 /SigmaFactorBS="gtgtcatgacctccagagcagttccttccttgatGACCGTGC CTtttttgagcgcgATCATATAATGAGAAAAACGagctgcatggttaagatcatgaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3066683 /Source="Nicolas_upshifts" /id="U2609" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1247 /SigmaFactorBS="gtgtcatgacctccagagcagttccttccttgatGACCGTGC CTtttttgagcgcgATCATATAATGAGAAAAACGagctgcatggttaagatcatgaat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3067326..3068336) /gene="fhuG" /locus_tag="BSU_33300" /old_locus_tag="BSU33300" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8388528, 8596459, 10913070, 15802251, 15849754, 16850406, 24362930; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ferrichrome ABC transporter (permease)" /protein_id="NP_391211.1" /db_xref="EnsemblGenomes-Gn:BSU33300" /db_xref="EnsemblGenomes-Tr:CAB15336" /db_xref="GOA:P49937" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG11391" /db_xref="UniProtKB/Swiss-Prot:P49937" /translation="MKTKTNKPLIVMAVTFLLIVVVFFISLNLGVIKIAPLKTLQVFF GQGTARDELVLFEFRLPRIILSLLVGAGISVAGAILQSVSQNELAEPGILGINAGGSL AVVLFIYFFQGSASDLSFFGTFMLPFSALAGAILAAFLIYILAWKKGVTPIRLILVGI GVNAGFNALLLIFQLKMDPHDFMQAAVWISGSIWGANWNMIWAILPWIVILLLFTLYK ARYLNIMQLGDQLATGLGTAVEKERRILLLAAVTLAASCVAAAGGIAFLGLIAPHVAR RLTGPRHQTLIPVSAFIGSFLFLLADTLARNVLAPSEIPVGLVISVLGAPYFIYLLMK AN*" /label="fhuG CDS" gene complement(3067326..3068336) /gene="fhuG" /locus_tag="BSU_33300" /old_locus_tag="BSU33300" /label="fhuG gene" CDS complement(3068336..3069490) /gene="fhuB" /locus_tag="BSU_33310" /old_locus_tag="BSU33310" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8388528, 12354229, 15849754, 16850406, 24362930; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ferrichrome ABC transporter (permease)" /protein_id="NP_391212.1" /db_xref="EnsemblGenomes-Gn:BSU33310" /db_xref="EnsemblGenomes-Tr:CAB15337" /db_xref="GOA:P49936" /db_xref="InterPro:IPR000522" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG11389" /db_xref="UniProtKB/Swiss-Prot:P49936" /translation="MHFHFCSKHSIKSAEKSDILKQQLIIIISNRKEVRQLSQHKNIR TASEEIQWTSRTYGAVIVLIAGLCLLCLGAFLSISLGAADIHLRTVWEAIFHYQPTKT SHQIIHDLRLPRTAAAALVGALLAVSGAIMQGMTRNPLAEPSIMGVTSGSAFAVSIAF AFFPGLSAMGLVLWSFAGAGLGASTVMGIGMFSRGGLTPVKLALAGTAVTYFFTGIST AIAIRFDVAQDISFWYAGGVAGVKWSGVQLLLIAGAVGLTLAFFIARSVTVLSLGDDL AKGLGQYTSAVKLVGMLIVVILTGAAVSIAGTIAFIGLIIPHITRFLVGVDYRWIIPC SAVLGAVLLVFADIAARLVNAPFETPVGALTSLIGVPFFFYLARRERRGL*" /label="fhuB CDS" gene complement(3068336..3069490) /gene="fhuB" /locus_tag="BSU_33310" /old_locus_tag="BSU33310" /label="fhuB gene" promotor_-10 complement(3069423..3069442) /Source="Nicolas_upshift_promotors" /id="U2610" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.58941058941059" /psig="0.994005994005994" /xcortree=2108 /SigmaFactorBS="atttttgcaaatgcattttcatttttgttcaaaacactcTAT TAAATcagctgaaaaaAGTGATATACTGAAACAGCAattgataatcattatcagtaac a" /listShort="fhuB, fhuG, fhuC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3069440) /Source="Nicolas_upshifts" /id="U2610" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.58941058941059" /psig="0.994005994005994" /xcortree=2108 /SigmaFactorBS="atttttgcaaatgcattttcatttttgttcaaaacactcTAT TAAATcagctgaaaaaAGTGATATACTGAAACAGCAattgataatcattatcagtaac a" /listShort="fhuB, fhuG, fhuC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3069454..3069461) /Source="Nicolas_upshift_promotors" /id="U2610" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.58941058941059" /psig="0.994005994005994" /xcortree=2108 /SigmaFactorBS="atttttgcaaatgcattttcatttttgttcaaaacactcTAT TAAATcagctgaaaaaAGTGATATACTGAAACAGCAattgataatcattatcagtaac a" /listShort="fhuB, fhuG, fhuC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3069502..3069509 /Source="Nicolas_upshift_promotors" /id="U2611" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.450549450549451" /psig="0.998001998001998" /xcortree=2104 /SigmaFactorBS="acaaaaatgaaaatgcatttgcaaaaataTCGTGTCAaccgg cacttgcagTGGTATAATCACAGATGATAatgattctctttttcatctatcttttaga a" /listShort="fhuD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3069524..3069543 /Source="Nicolas_upshift_promotors" /id="U2611" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.450549450549451" /psig="0.998001998001998" /xcortree=2104 /SigmaFactorBS="acaaaaatgaaaatgcatttgcaaaaataTCGTGTCAaccgg cacttgcagTGGTATAATCACAGATGATAatgattctctttttcatctatcttttaga a" /listShort="fhuD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3069533 /Source="Nicolas_upshifts" /id="U2611" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.450549450549451" /psig="0.998001998001998" /xcortree=2104 /SigmaFactorBS="acaaaaatgaaaatgcatttgcaaaaataTCGTGTCAaccgg cacttgcagTGGTATAATCACAGATGATAatgattctctttttcatctatcttttaga a" /listShort="fhuD" /GFF_Attribute="listLong" /label="upshifts" CDS 3069588..3070535 /gene="fhuD" /locus_tag="BSU_33320" /old_locus_tag="BSU33320" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8388528, 12354229, 26919525; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ferrichrome ABC transporter (ferrichrome-bindinglipoprotein)" /protein_id="NP_391213.1" /db_xref="EnsemblGenomes-Gn:BSU33320" /db_xref="EnsemblGenomes-Tr:CAB15338" /db_xref="GOA:P37580" /db_xref="InterPro:IPR002491" /db_xref="PDB:3G9Q" /db_xref="PDB:3HXP" /db_xref="SubtiList:BG10828" /db_xref="UniProtKB/Swiss-Prot:P37580" /translation="MTHIYKKLGAAFFALLLIAALAACGNNSESKGSASDSKGAETFT YKAENGNVKIPKHPKRVVVMADGYYGYFKTLGINVVGAPENVFKNPYYKGKTNGVENI GDGTSVEKVIDLNPDLIIVWTTQGADIKKLEKIAPTVAVKYDKLDNIEQLKEFAKMTG TEDKAEKWLAKWDKKVAAAKTKIKKAVGDKTISIMQTNGKDIYVFGKDFGRGGSIIYK DLGLQATKLTKEKAIDQGPGYTSISLEKLPDFAGDYIFAGPWQSGGDDGGVFESSIWK NLNAVKNGHVYKMDPIGFYFTDPISLEGQLEFITESLTK*" /label="fhuD CDS" gene 3069588..3070535 /gene="fhuD" /locus_tag="BSU_33320" /old_locus_tag="BSU33320" /label="fhuD gene" downshifts 3070511 /Source="Nicolas_upshifts" /id="D1721" /incds=0 /nref=168 /ntot=245 /MaxReadThrough="3.82329" /MaxDrop="5.73183" /score="11.0136807" /energy="-12.1" /TU="U2611" /idTUdmin="U2611" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" downshifts 3070555 /Source="Nicolas_upshifts" /id="D1722" /incds=0 /nref=1 /ntot=1 /MaxReadThrough="3.01143" /MaxDrop="4.08479" /score="11.0136807" /energy="-12.1" /TU="NA" /idTUdmin="U2611" /TUdmin=22 /isTUend="TRUE" /label="downshifts" downshifts 3070709 /Source="Nicolas_upshifts" /id="D1723" /incds=0 /nref=8 /ntot=87 /MaxReadThrough="0.219110000000001" /MaxDrop="3.67928" /score="7.53231618" /energy="-13.7" /TU="NA" /idTUdmin="U2611" /TUdmin=176 /isTUend="FALSE" /label="downshifts" CDS complement(3070770..3072179) /gene="lysP" /locus_tag="BSU_33330" /old_locus_tag="BSU33330" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 14627808, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="lysine permease" /protein_id="NP_391214.1" /db_xref="EnsemblGenomes-Gn:BSU33330" /db_xref="EnsemblGenomes-Tr:CAB15339" /db_xref="GOA:O32204" /db_xref="InterPro:IPR002293" /db_xref="SubtiList:BG14154" /db_xref="UniProtKB/Swiss-Prot:O32204" /translation="MEQTKKWGFWLLTAFVVGNMVGSGIFSLPSSLASIASPFGATSA WLLTGAGVLMIALVFGHLSIRKPELTAGPQSYARALFSDPKKGNAAGFTMVWGYWVAS WISNVAIITSLAGYLTSFFPILVDKREMFSIGGQEVTLGQLLTFAVCTILLWGTHAIL VASINGASKLNFVTTLSKVLGFVFFIVAGLFVFQTSLFGHFYFPVQGENGTSIGIGGQ VHNAAISTLWAFVGIESAVILSGRARSQRDVKRATITGLLIALSIYIIVTLITMGVLP HDKLVGSEKPFVDVLYAIVGNAGSVIMALLAILCLFGTMLGWILLGSEVPYQAAKAGD FPAFFAKTNKKGSPVIALIITNVMSQVFIFSVISRTISDAFTFLTTAATLAYLIPYLV SAIYSLKVVIKGETYDQLKGSRVRDGLIAILACAYSVFVIVTGTADLTTFILGIGLFF VGLIVYPFVSNKFQKEKQA*" /label="lysP CDS" gene complement(3070770..3072179) /gene="lysP" /locus_tag="BSU_33330" /old_locus_tag="BSU33330" /label="lysP gene" downshifts complement(3070785) /Source="Nicolas_upshifts" /id="D1724" /incds=0 /nref=168 /ntot=213 /MaxReadThrough="0.441040000000001" /MaxDrop="6.03347" /score="23.064706" /energy="-13.7" /TU="NA" /idTUdmin="U2613" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 3071597..3071601 /Source="Nicolas_upshift_promotors" /id="U2612" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.3996003996004" /psig="0.3996003996004" /xcortree=1015 /SigmaFactorBS="accgggaaataaaaatgaccgaataatgacgTTTGAaacaca aacaaaccggcAACGATAAAGAAGACAAaacctaatactttagaaagcgttgtgacaa a" /listShort="S1279, yvsG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3071619..3071635 /Source="Nicolas_upshift_promotors" /id="U2612" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.3996003996004" /psig="0.3996003996004" /xcortree=1015 /SigmaFactorBS="accgggaaataaaaatgaccgaataatgacgTTTGAaacaca aacaaaccggcAACGATAAAGAAGACAAaacctaatactttagaaagcgttgtgacaa a" /listShort="S1279, yvsG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3071626 /Source="Nicolas_upshifts" /id="U2612" /multdbtbs="-" /comp="M10" /sig="Sig-" /pcomp="0.3996003996004" /psig="0.3996003996004" /xcortree=1015 /SigmaFactorBS="accgggaaataaaaatgaccgaataatgacgTTTGAaacaca aacaaaccggcAACGATAAAGAAGACAAaacctaatactttagaaagcgttgtgacaa a" /listShort="S1279, yvsG" /GFF_Attribute="listLong" /label="upshifts" S_feature 3071633..3072600 /Source="Nicolas_S_feature" /locus_tag="new_3420519_3421486" /HighExp="S3, S4, S7, S5, S8, S6, Etha, M9-stat, T5.0H, T4.0H" /AntisenseName="NA" /AntisenseCor="7.6401427420847101E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.4" /TUlongSig="NA" /TUlongPSig="NA" /label="S1279" downshifts complement(3072281) /Source="Nicolas_upshifts" /id="D1725" /incds=0 /nref=1 /ntot=43 /MaxReadThrough="5.98281" /MaxDrop="3.61093" /score="-2.14086757" /energy="-5" /TU="U2613,U2614" /idTUdmin="U2614" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" misc_RNA complement(3072283..3072462) /gene="kswB" /locus_tag="BSU_misc_RNA_54" /product="lysine riboswitch" /experiment="publication(s) with functional evidences, PMID:22416067" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22416067; Product type n: RNA" /label="kswB RNA" gene complement(3072283..3072462) /gene="kswB" /locus_tag="BSU_misc_RNA_54" /label="kswB gene" promotor_-10 complement(3072492..3072509) /Source="Nicolas_upshift_promotors" /id="U2613" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.566433566433566" /psig="0.98101898101898" /xcortree=2399 /SigmaFactorBS="gcttggctctatccgtattttccatctgttccCTTTGACAga tcatcctttcttTGATAACCTTCTGGGAGTaactgaataattaaatcctcactctttc t" /listShort="NA, lysP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3072503) /Source="Nicolas_upshifts" /id="U2613" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.566433566433566" /psig="0.98101898101898" /xcortree=2399 /SigmaFactorBS="gcttggctctatccgtattttccatctgttccCTTTGACAga tcatcctttcttTGATAACCTTCTGGGAGTaactgaataattaaatcctcactctttc t" /listShort="NA, lysP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3072524..3072531) /Source="Nicolas_upshift_promotors" /id="U2613" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.566433566433566" /psig="0.98101898101898" /xcortree=2399 /SigmaFactorBS="gcttggctctatccgtattttccatctgttccCTTTGACAga tcatcctttcttTGATAACCTTCTGGGAGTaactgaataattaaatcctcactctttc t" /listShort="NA, lysP" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3072557 /Source="Nicolas_upshifts" /id="D1726" /incds=0 /nref=1 /ntot=10 /MaxReadThrough="3.6441" /MaxDrop="3.53891" /score="-0.527038766" /energy="-4.8" /TU="U2612" /idTUdmin="U2612" /TUdmin="-462" /isTUend="FALSE" /label="downshifts" CDS complement(3072579..3072719) /gene="sspJ" /locus_tag="BSU_33340" /old_locus_tag="BSU33340" /function="16.13: Shape" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9852018" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9852018; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="small acid-soluble spore protein" /protein_id="YP_054593.1" /db_xref="EnsemblGenomes-Gn:BSU33340" /db_xref="EnsemblGenomes-Tr:CAE01467" /db_xref="GOA:Q7WY58" /db_xref="InterPro:IPR014220" /db_xref="SubtiList:BG14174" /db_xref="UniProtKB/Swiss-Prot:Q7WY58" /translation="MGFFNKDKGKRSEKEKNVIQGALEDAGSALKDDPLQEAVQKKKN NR*" /label="sspJ CDS" gene complement(3072579..3072719) /gene="sspJ" /locus_tag="BSU_33340" /old_locus_tag="BSU33340" /label="sspJ gene" downshifts complement(3072589) /Source="Nicolas_upshifts" /id="D1727" /incds=0 /nref=40 /ntot=87 /MaxReadThrough="4.06523" /MaxDrop="5.5784" /score="-1.94521013" /energy="-14.5" /TU="U2614" /idTUdmin="U2614" /TUdmin="-418" /isTUend="FALSE" /label="downshifts" upshifts complement(3072747) /Source="Nicolas_upshifts" /id="U2614" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=839 /SigmaFactorBS="gactttggacgataaaaaatatccCGCATAAtttttcaggaa aaAGGCATCTTAAAcatgtacctattttttaaaagaggtgatacgaatgggtttcttt a" /listShort="sspJ, NA" /listLong="lysP" /label="upshifts" S_feature complement(3072749..3073337) /Source="Nicolas_S_feature" /locus_tag="new_3421635_3422223_c" /HighExp="S6, S8, S7, S5, BT, G135, Diami, G180, LBGstat, S4" /AntisenseName="yvsG" /AntisenseCor="0.46604658967097301" /AntisenseRegPval="-15.2" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1280" promotor_-10 complement(3072752..3072763) /Source="Nicolas_upshift_promotors" /id="U2614" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=839 /SigmaFactorBS="gactttggacgataaaaaatatccCGCATAAtttttcaggaa aaAGGCATCTTAAAcatgtacctattttttaaaagaggtgatacgaatgggtttcttt a" /listShort="sspJ, NA" /listLong="lysP" /label="promotor_-10" promotor_-35 complement(3072777..3072783) /Source="Nicolas_upshift_promotors" /id="U2614" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=839 /SigmaFactorBS="gactttggacgataaaaaatatccCGCATAAtttttcaggaa aaAGGCATCTTAAAcatgtacctattttttaaaagaggtgatacgaatgggtttcttt a" /listShort="sspJ, NA" /listLong="lysP" /label="promotor_-35" promotor_-35 3072809..3072816 /Source="Nicolas_upshift_promotors" /id="U2615" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.82017982017982" /psig="0.997002997002997" /xcortree=2476 /SigmaFactorBS="tgaaaaattatgcgggatattttttatcgtccaaagtccTGT TGATCaaacatacattctctTGATATATTTGTAATTCAGAgattttttgcaaaagata a" /listShort="yvsG, yvgJ" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3072830 /Source="Nicolas_upshifts" /id="U2615" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.82017982017982" /psig="0.997002997002997" /xcortree=2476 /SigmaFactorBS="tgaaaaattatgcgggatattttttatcgtccaaagtccTGT TGATCaaacatacattctctTGATATATTTGTAATTCAGAgattttttgcaaaagata a" /listShort="yvsG, yvgJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3072832..3072851 /Source="Nicolas_upshift_promotors" /id="U2615" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.82017982017982" /psig="0.997002997002997" /xcortree=2476 /SigmaFactorBS="tgaaaaattatgcgggatattttttatcgtccaaagtccTGT TGATCaaacatacattctctTGATATATTTGTAATTCAGAgattttttgcaaaagata a" /listShort="yvsG, yvgJ" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3072886..3073368 /gene="yvsG" /locus_tag="BSU_33350" /old_locus_tag="BSU33350" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16267290, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane hydrolase" /protein_id="NP_391215.1" /db_xref="EnsemblGenomes-Gn:BSU33350" /db_xref="EnsemblGenomes-Tr:CAB15340" /db_xref="GOA:O32205" /db_xref="InterPro:IPR007404" /db_xref="InterPro:IPR016956" /db_xref="SubtiList:BG14153" /db_xref="UniProtKB/Swiss-Prot:O32205" /translation="MTGKTHIMGGIASCTAAAYYYGFDPVLMAASGAVGALIPDICHT QSKIGRKFPILSKVVSSVFGHRTFTHSLLFMLIMFFITSTYIPDKNISAGLMIGMASH LILDAWTVNGIKLLFPSTIRVRLPLYMKTGSFSEQLVLAGLTLASCYYFYMLFHGRMF *" /label="yvsG CDS" gene 3072886..3073368 /gene="yvsG" /locus_tag="BSU_33350" /old_locus_tag="BSU33350" /label="yvsG gene" promotor_-35 3073382..3073389 /Source="Nicolas_upshift_promotors" /id="U2616" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.724275724275724" /psig="0.999000999001" /xcortree=1927 /SigmaFactorBS="gccgcatgttttaaacatgagtgctgaGACTTGTCtgaaccg gctgttTTTAGTAGGTTTTACTTAAGaagcatttcatgcagatgatcaagaaaacgtg a" /listShort="yvgJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3073403..3073422 /Source="Nicolas_upshift_promotors" /id="U2616" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.724275724275724" /psig="0.999000999001" /xcortree=1927 /SigmaFactorBS="gccgcatgttttaaacatgagtgctgaGACTTGTCtgaaccg gctgttTTTAGTAGGTTTTACTTAAGaagcatttcatgcagatgatcaagaaaacgtg a" /listShort="yvgJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3073415 /Source="Nicolas_upshifts" /id="U2616" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.724275724275724" /psig="0.999000999001" /xcortree=1927 /SigmaFactorBS="gccgcatgttttaaacatgagtgctgaGACTTGTCtgaaccg gctgttTTTAGTAGGTTTTACTTAAGaagcatttcatgcagatgatcaagaaaacgtg a" /listShort="yvgJ" /GFF_Attribute="listLong" /label="upshifts" CDS 3073468..3075321 /gene="ltaSP" /locus_tag="BSU_33360" /old_locus_tag="BSU33360" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15187182, 21255105, 23103977, 25288647" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15187182, 21255105, 23103977, 25288647; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="primase of polyglycerolphosphate lipoteichoic acid (LTA) synthesis" /protein_id="NP_391216.1" /db_xref="EnsemblGenomes-Gn:BSU33360" /db_xref="EnsemblGenomes-Tr:CAB15341" /db_xref="GOA:O32206" /db_xref="InterPro:IPR000917" /db_xref="InterPro:IPR012160" /db_xref="InterPro:IPR017849" /db_xref="InterPro:IPR017850" /db_xref="SubtiList:BG14092" /db_xref="UniProtKB/Swiss-Prot:O32206" /translation="MKGTFFHNQRFLCFSILFMWIKTYVIYKLGFDLQIDTLLEELML LVNPLSFILPLFGIGLFLKENKQRAFLLIANLVLTVILISNTIFYGFYIDFITIPVLF QASNMSDMGSSVKELFHPLFIALFVDLVFLLLFARKTKHPQTKAAPHTIKRYYAASCG MLLCTLALAEVQQPKLLAHSFDREMLVKSIGLFQFHIYDTISQTVNISAKAFADEDSI TAIKNYTEADYSKPDQSKFGLAKGRNVIFVTLESTQSFVLNEKVNGKEITPFMNDLIK KSYSFDHFYQQTEQGKTSDSEFIVANSLYPSLSGAVFFTKSDHQFHTMYKSLKQHDYY SAVFHANHKTFWNRDVMYDTFGIDRFFDVDDFHVTPGTSTSWGLKDKEFLEQSAKKLK SLPQPFYSSFITLTNHFPFEIDEKDQLIDEFDSSSDLLNRYVTTVRYEDEALKHFIKK LKDEGLYENSMIVFMGDHYGISEAHNEAMAEFLGKDEITPYDNVQLQRVPFIIHIPGI TDQQPETIPDAGGQVDVRPTLMHLLGVETKGDIQFGNDLLSGDRTPFAVLRNGSFITN DYVYTKNTCYSQKTGEVLEDQDACLPYKEKANEELSLSDKILNGDLLRFSE*" /label="ltaSP CDS" gene 3073468..3075321 /gene="ltaSP" /locus_tag="BSU_33360" /old_locus_tag="BSU33360" /label="ltaSP gene" downshifts 3075307 /Source="Nicolas_upshifts" /id="D1728" /incds=0 /nref=30 /ntot=171 /MaxReadThrough="1.18268" /MaxDrop="3.6959" /score="21.1397957" /energy="-10.5" /TU="NA" /idTUdmin="U2615" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3075349..3076275) /gene="yvgK" /locus_tag="BSU_33370" /old_locus_tag="BSU33370" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative molybdate binding regulator" /protein_id="NP_391217.1" /db_xref="EnsemblGenomes-Gn:BSU33370" /db_xref="EnsemblGenomes-Tr:CAB15342" /db_xref="GOA:O32207" /db_xref="InterPro:IPR009061" /db_xref="InterPro:IPR010093" /db_xref="InterPro:IPR024370" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG14093" /db_xref="UniProtKB/Swiss-Prot:O32207" /translation="MNETSSYTIEEVAGLLKVSKLTVYDLIKKGVLPAYRVGRQMRVD EEDLKQYKTNMRMSQPIAAKEAPKQVQEAEPDGRPNVMISGQDISMDILSKHLENAIQ ETPLRKYKGSLNSLIDMYQGKCDIVSLHLYDAETGQYNAPYVKRILTGEPFCLINVVL RKAGLYVQKGNPKNIQGWKDLKRADIRIINREKGSGARVLLDEQLGLLGVNPADVVGY GDIVTDHYAAASQVSSGQADAGIGAQHAAHMGSVDFIPLIDEQYDIVVLKKNEQLLKA VKEILNSEDYKANLSHLNGYETKLTGKVILET*" /label="yvgK CDS" gene complement(3075349..3076275) /gene="yvgK" /locus_tag="BSU_33370" /old_locus_tag="BSU33370" /label="yvgK gene" downshifts complement(3075361) /Source="Nicolas_upshifts" /id="D1729" /incds=0 /nref=232 /ntot=260 /MaxReadThrough="0.15268" /MaxDrop="6.72558" /score="21.9965704" /energy="-10.5" /TU="NA" /idTUdmin="U2617" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3076287..3076306) /Source="Nicolas_upshift_promotors" /id="U2617" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.712287712287712" /psig="0.997002997002997" /xcortree=2738 /SigmaFactorBS="ttagatataactaattataactgattatgtttggtttatgtg gGTTTttttacattcggcgaAAAGGTATAATAAAATAGGAgagtgatgatgatgaatg a" /listShort="yvgK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3076308) /Source="Nicolas_upshifts" /id="U2617" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.712287712287712" /psig="0.997002997002997" /xcortree=2738 /SigmaFactorBS="ttagatataactaattataactgattatgtttggtttatgtg gGTTTttttacattcggcgaAAAGGTATAATAAAATAGGAgagtgatgatgatgaatg a" /listShort="yvgK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3076322..3076325) /Source="Nicolas_upshift_promotors" /id="U2617" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.712287712287712" /psig="0.997002997002997" /xcortree=2738 /SigmaFactorBS="ttagatataactaattataactgattatgtttggtttatgtg gGTTTttttacattcggcgaAAAGGTATAATAAAATAGGAgagtgatgatgatgaatg a" /listShort="yvgK" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 3076344..3076363 /Source="Nicolas_upshift_promotors" /id="U2618" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.616383616383616" /psig="0.95104895104895" /xcortree=2395 /SigmaFactorBS="tttattataccttttcgccgaatgtaaaaaaacccacataaa ccaaacataATCAGTTATAATTAGTTATAtctaatgataaggggtgcaatcatgttta a" /listShort="yvgL, yvgM" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3076353 /Source="Nicolas_upshifts" /id="U2618" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.616383616383616" /psig="0.95104895104895" /xcortree=2395 /SigmaFactorBS="tttattataccttttcgccgaatgtaaaaaaacccacataaa ccaaacataATCAGTTATAATTAGTTATAtctaatgataaggggtgcaatcatgttta a" /listShort="yvgL, yvgM" /GFF_Attribute="listLong" /label="upshifts" CDS 3076386..3077168 /gene="modA" /locus_tag="BSU_33380" /old_locus_tag="BSU33380" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9302996; Product type lp : lipoprotein" /codon_start=1 /transl_table=11 /product="molybdate-binding lipoprotein" /protein_id="NP_391218.1" /db_xref="EnsemblGenomes-Gn:BSU33380" /db_xref="EnsemblGenomes-Tr:CAB15343" /db_xref="GOA:O32208" /db_xref="InterPro:IPR005950" /db_xref="SubtiList:BG14094" /db_xref="UniProtKB/Swiss-Prot:O32208" /translation="MFKKYSIFIAALTAFLLVAGCSSNQSSTDSEKKVTLTISAAASA QDALEEIQKNYEKDHQHITIQDNYGSSGALQKQISQGAGADLFFSAAEDKFKKLVDDG DIAKKDSTELVGNEIVLVVPKNGDSPVTSFSNLAESEKIALGTPESVPAGAYGKESLT KLSLWDKVKDKIVYGKDVRQVLSYVETGNVDAGVVYKTDALVSKKVNIVDEAKADTHS PIVYPLGIVKDTKHRKEAKEFYEYLQSDEAMKVFEKYGFTAE*" /label="modA CDS" gene 3076386..3077168 /gene="modA" /locus_tag="BSU_33380" /old_locus_tag="BSU33380" /label="modA gene" CDS 3077140..3077832 /gene="modB" /locus_tag="BSU_33390" /old_locus_tag="BSU33390" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="molybdenum transport permease" /protein_id="NP_391219.3" /db_xref="EnsemblGenomes-Gn:BSU33390" /db_xref="EnsemblGenomes-Tr:CAB15344" /db_xref="GOA:O32209" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR011867" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG14095" /db_xref="UniProtKB/Swiss-Prot:O32209" /translation="MRNMALLPSSISASEFFTPVVLSFQVAAVAGIVVIILGTLAGAW MSRASFFGKTALETCFMLPLVLPPTVVGFILIVIFGKHSFIGQAIEWIFQQPVIFTWW AAVIASAVVAFPLMYQSAKTGFADIDPDIQGAAMVDGASRWKVFIHISVPLAYPSLLT GSILSLARALGEFGATLMFAGNIPGVTQTLPTAIYVALDSGNNTLAWAWVVCIVVISF LMLFFIQQKKTH*" /label="modB CDS" gene 3077140..3077832 /gene="modB" /locus_tag="BSU_33390" /old_locus_tag="BSU33390" /label="modB gene" downshifts 3077824 /Source="Nicolas_upshifts" /id="D1730" /incds=0 /nref=40 /ntot=195 /MaxReadThrough="0.43895" /MaxDrop="4.92503" /score="19.0609965" /energy="-9.4" /TU="NA" /idTUdmin="U2618" /TUdmin=9 /isTUend="TRUE" /label="downshifts" CDS complement(3077863..3078693) /gene="pgoN" /locus_tag="BSU_33400" /old_locus_tag="BSU33400" /EC_number="1.1.1.283" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11544192, 16232966, 17114254, 19585557" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11544192, 16232966, 17114254, 19585557; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous glyoxal/methylglyoxal reductase" /protein_id="NP_391220.1" /db_xref="EnsemblGenomes-Gn:BSU33400" /db_xref="EnsemblGenomes-Tr:CAB15345" /db_xref="GOA:O32210" /db_xref="InterPro:IPR018170" /db_xref="InterPro:IPR020471" /db_xref="InterPro:IPR023210" /db_xref="InterPro:IPR036812" /db_xref="PDB:3D3F" /db_xref="PDB:3F7J" /db_xref="SubtiList:BG14096" /db_xref="UniProtKB/Swiss-Prot:O32210" /translation="MPTSLKDTVKLHNGVEMPWFGLGVFKVENGNEATESVKAAIKNG YRSIDTAAIYKNEEGVGIGIKESGVAREELFITSKVWNEDQGYETTLAAFEKSLERLQ LDYLDLYLIHWPGKDKYKDTWRALEKLYKDGKIRAIGVSNFQVHHLEELLKDAEIKPM VNQVEFHPRLTQKELRDYCKGQGIQLEAWSPLMQGQLLDNEVLTQIAEKHNKSVAQVI LRWDLQHGVVTIPKSIKEHRIIENADIFDFELSQEDMDKIDALNKDERVGPNPDELLF *" /label="pgoN CDS" gene complement(3077863..3078693) /gene="pgoN" /locus_tag="BSU_33400" /old_locus_tag="BSU33400" /label="pgoN gene" downshifts complement(3077869) /Source="Nicolas_upshifts" /id="D1731" /incds=0 /nref=190 /ntot=269 /MaxReadThrough="4.7445" /MaxDrop="7.9269" /score="27.8070829" /energy="-9.7" /TU="U2620" /idTUdmin="U2620" /TUdmin="-528" /isTUend="FALSE" /label="downshifts" promotor_-35 3078556..3078560 /Source="Nicolas_upshift_promotors" /id="U2619" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.971028971028971" /psig="0.001998001998002" /xcortree=43 /SigmaFactorBS="catttttgtagatcgctgctgtatcaatactGCGATagccat ttttaattgCCGCTttcactgattcagtcgcttcattaccattttctactttaaaaac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3078576..3078580 /Source="Nicolas_upshift_promotors" /id="U2619" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.971028971028971" /psig="0.001998001998002" /xcortree=43 /SigmaFactorBS="catttttgtagatcgctgctgtatcaatactGCGATagccat ttttaattgCCGCTttcactgattcagtcgcttcattaccattttctactttaaaaac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3078585 /Source="Nicolas_upshifts" /id="U2619" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.971028971028971" /psig="0.001998001998002" /xcortree=43 /SigmaFactorBS="catttttgtagatcgctgctgtatcaatactGCGATagccat ttttaattgCCGCTttcactgattcagtcgcttcattaccattttctactttaaaaac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 3078695 /Source="Nicolas_upshifts" /id="D1732" /incds=0 /nref=2 /ntot=122 /MaxReadThrough="0.95687" /MaxDrop="4.12116" /score="31.5807071" /energy="-11.6" /TU="NA" /idTUdmin="U2618" /TUdmin=880 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3078723..3078742) /Source="Nicolas_upshift_promotors" /id="U2620" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=1944 /SigmaFactorBS="tgtgaaaaaagaagcaaaaagagggtcttaagcgtatTATTG GTAtcggctgagaggaaTGTGAGATAATATAGACGCTtacatttcagtgaaagggtgg a" /listShort="yvgN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3078741) /Source="Nicolas_upshifts" /id="U2620" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=1944 /SigmaFactorBS="tgtgaaaaaagaagcaaaaagagggtcttaagcgtatTATTG GTAtcggctgagaggaaTGTGAGATAATATAGACGCTtacatttcagtgaaagggtgg a" /listShort="yvgN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3078757..3078764) /Source="Nicolas_upshift_promotors" /id="U2620" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96003996003996" /psig="0.998001998001998" /xcortree=1944 /SigmaFactorBS="tgtgaaaaaagaagcaaaaagagggtcttaagcgtatTATTG GTAtcggctgagaggaaTGTGAGATAATATAGACGCTtacatttcagtgaaagggtgg a" /listShort="yvgN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3078849..3078855 /Source="Nicolas_upshift_promotors" /id="U2621" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=146 /SigmaFactorBS="caaatccaaacactatttttttcctattttaacaatattgAG ATTACaaatacattgagcaGGGTATGCGTGTAGTGTAAccaaatgaaaacaaaggagg a" /listShort="yvgO" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3078869 /Source="Nicolas_upshifts" /id="U2621" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=146 /SigmaFactorBS="caaatccaaacactatttttttcctattttaacaatattgAG ATTACaaatacattgagcaGGGTATGCGTGTAGTGTAAccaaatgaaaacaaaggagg a" /listShort="yvgO" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3078870..3078888 /Source="Nicolas_upshift_promotors" /id="U2621" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=146 /SigmaFactorBS="caaatccaaacactatttttttcctattttaacaatattgAG ATTACaaatacattgagcaGGGTATGCGTGTAGTGTAAccaaatgaaaacaaaggagg a" /listShort="yvgO" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3078916..3079401 /gene="yvgO" /locus_tag="BSU_33410" /old_locus_tag="BSU33410" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 11988534, 22307285, 25217289; Product type f: factor" /codon_start=1 /transl_table=11 /product="exported stress induced factor" /protein_id="NP_391221.1" /db_xref="EnsemblGenomes-Gn:BSU33410" /db_xref="EnsemblGenomes-Tr:CAB15346" /db_xref="SubtiList:BG14097" /db_xref="UniProtKB/Swiss-Prot:O32211" /translation="MKRIRIPMTLALGAALTIAPLSFASAEENPAPKMSQTTTAGTTA ADVGLNVNLDVLGIANQIADAIKSAQNRDGFVKNLMESSFYASGQKYNVMVFNLSQEY EDHLNGVQFYGSAVYDGITYGIWVFEDGTFTNKGDGGWINWAFRGWFDRDGSTVAFHR P*" /label="yvgO CDS" gene 3078916..3079401 /gene="yvgO" /locus_tag="BSU_33410" /old_locus_tag="BSU33410" /label="yvgO gene" downshifts 3079400 /Source="Nicolas_upshifts" /id="D1733" /incds=0 /nref=18 /ntot=93 /MaxReadThrough="3.44281" /MaxDrop="6.83046" /score="31.5807071" /energy="-11.6" /TU="U2621" /idTUdmin="U2621" /TUdmin="-571" /isTUend="FALSE" /label="downshifts" CDS complement(3079445..3081457) /gene="nhaK" /locus_tag="BSU_33420" /old_locus_tag="BSU33420" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16021482, 16850406, 28420751" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16021482, 16850406, 28420751; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Na+/H+ antiporter" /protein_id="NP_391222.1" /db_xref="EnsemblGenomes-Gn:BSU33420" /db_xref="EnsemblGenomes-Tr:CAB15347" /db_xref="GOA:O32212" /db_xref="InterPro:IPR004705" /db_xref="InterPro:IPR006153" /db_xref="InterPro:IPR018422" /db_xref="SubtiList:BG14098" /db_xref="UniProtKB/Swiss-Prot:O32212" /translation="MDIFLVVLVLLTIIAISNIVNRFIPFIPVPLIQVALGILAASFP QGLHFELNTELFFVLFIAPLLFNDGKRTPRAELWNLRAPILLLALGLVFATVIVGGYT IHWMIPAIPLAAAFGLAAILSPTDVVAVSALSGRVKMPKGILRLLEGEGLMNDASGLV AFKFAIAAAVTGAFSLAQAAVSFVFISLGGLLCGVVISFLIIRFRLFLRRLGMQDVTM HMLIQILTPFVIYLAAEEIGVSGILAVVAGGITHAVEQDRLESTMIKLQIVSSSTWNI ILFILNGLVFVILGTQIPDVISVIFNDTAISNMKVIGYILVITFTLMLLRFLWVLFFW NGKWFFNKDQNIYKPGLRSTLLISISGVRGAVTLAGSFSIPYFLEDGTPFPERNLILF LAAGVILCTLVIATVVLPILTEKEEEDEERNKKLLTARRKLIKTALQTIKEDMNETNK TASLAVIAEYNEKMKNLRFQQYTSSNRIKKHERKVRAQGVKAEQEALMKMLERGDIPE ETANVLQERFNELEILYANPFKVGLSKTRLKRLMYWIFFGEHKKPEMSILNEAGLIRA TRVKTAKAAIEYLEKHKTDEHKEVFLSVITFYKQLIFRLEHSHHELKSSAHFENQKLE VKLKAVQAIRNEIQTLFEEREISRDISHELRQYINDVEAAMLEGGE*" /label="nhaK CDS" gene complement(3079445..3081457) /gene="nhaK" /locus_tag="BSU_33420" /old_locus_tag="BSU33420" /label="nhaK gene" downshifts complement(3079453) /Source="Nicolas_upshifts" /id="D1734" /incds=0 /nref=118 /ntot=238 /MaxReadThrough="2.66359" /MaxDrop="5.82216" /score="41.6492295" /energy="-13.2" /TU="NA" /idTUdmin="U2622" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(3081123..3081127) /Source="Nicolas_upshift_promotors" /id="U2622" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.403596403596404" /psig="0.04995004995005" /xcortree=1527 /SigmaFactorBS="tgtatttgcgactgtgattgtaggcggctacacgattcactg gatgattcctgctattCCGCTggcagcggcctttggacttgcggccattctttcaccg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3081125) /Source="Nicolas_upshifts" /id="U2622" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.403596403596404" /psig="0.04995004995005" /xcortree=1527 /SigmaFactorBS="tgtatttgcgactgtgattgtaggcggctacacgattcactg gatgattcctgctattCCGCTggcagcggcctttggacttgcggccattctttcaccg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3081458..3081609) /Source="Nicolas_S_feature" /locus_tag="new_3430344_3430495_c" /HighExp="dia5, T0.30H, T-0.40H, Salt, Diami, T1.0H, T0.0H, T1.30H, dia15, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.746, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1281" misc_feature complement(3081586..3081604) /Source="Nicolas_upshift_promotors" /id="U2623" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.341658341658342" /psig="0.746253746253746" /xcortree=1528 /SigmaFactorBS="ttctataatttgctcttctgcaaaaaagttcactgtgagcat atcatgagaaaaaataccctaaaAAGGGTACTATAAAAGAAGacaagtgtggagagaa c" /listShort="S1281, nhaK" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3081609) /Source="Nicolas_upshifts" /id="U2623" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.341658341658342" /psig="0.746253746253746" /xcortree=1528 /SigmaFactorBS="ttctataatttgctcttctgcaaaaaagttcactgtgagcat atcatgagaaaaaataccctaaaAAGGGTACTATAAAAGAAGacaagtgtggagagaa c" /listShort="S1281, nhaK" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3081712..3083427) /gene="cysI" /locus_tag="BSU_33430" /old_locus_tag="BSU33430" /EC_number="1.8.1.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11445163, 12169591, 16267287" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11445163, 12169591, 16267287; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="assimilatory sulfite reductase (hemoprotein beta-subunit)" /protein_id="NP_391223.1" /db_xref="EnsemblGenomes-Gn:BSU33430" /db_xref="EnsemblGenomes-Tr:CAB15348" /db_xref="GOA:O32213" /db_xref="InterPro:IPR005117" /db_xref="InterPro:IPR006066" /db_xref="InterPro:IPR006067" /db_xref="InterPro:IPR011786" /db_xref="InterPro:IPR036136" /db_xref="SubtiList:BG14099" /db_xref="UniProtKB/Swiss-Prot:O32213" /translation="MVTKILKAPDGSPSDVERIKKESDYLRGTLKEVMLDRISAGIPD DDNRLMKHHGSYLQDDRDLRNERQKQKLEPAYQFMLRVRMPGGVSTPEQWLVMDDLSQ KYGNGTLKLTTRETFQMHGILKWNMKKTIQTIHSALLDTIAACGDVNRNVMCASNPYQ SEIHSEVYEWSKKLSDDLLPRTRAYHEIWLDEERVAGTPEEEVEPMYGPLYLPRKFKI GIAVPPSNDIDVFSQDLGFIAIVEDGKLIGFNVAIGGGMGMTHGDTATYPQLAKVIGF CRPEQMYDVAEKTITIQRDYGNRSVRKNARFKYTVDRLGLENVKEELENRLGWSLEEA KPYHFDHNGDRYGWVEGIEDKWHFTLFVEGGRITDYDDYKLMTGLREIAKVHTGEFRL TANQNLMIANVSSDKKEEISALIEQYGLTDGKHYSALRRSSMACVALPTCGLAMAEAE RYLPTLLDKIEEIIDENGLRDQEITIRMTGCPNGCARHALGEIGFIGKAPGKYNMYLG AAFDGSRLSKMYRENIGEADILSELRILLSRYAKEREEGEHFGDFVIRAGIIKATTDG TNFHD*" /label="cysI CDS" gene complement(3081712..3083427) /gene="cysI" /locus_tag="BSU_33430" /old_locus_tag="BSU33430" /label="cysI gene" downshifts complement(3081719) /Source="Nicolas_upshifts" /id="D1735" /incds=0 /nref=211 /ntot=254 /MaxReadThrough="3.28258" /MaxDrop="6.31358" /score="23.5256972" /energy="-13.8" /TU="U2624" /idTUdmin="U2624" /TUdmin="-572" /isTUend="FALSE" /label="downshifts" CDS complement(3083453..3085270) /gene="cysJ" /locus_tag="BSU_33440" /old_locus_tag="BSU33440" /EC_number="1.8.1.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11445163, 12169591, 16267287, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11445163, 12169591, 16267287, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="assimilatory sulfite reductase (flavoprotein alpha-subunit)" /protein_id="NP_391224.1" /db_xref="EnsemblGenomes-Gn:BSU33440" /db_xref="EnsemblGenomes-Tr:CAB15349" /db_xref="GOA:O32214" /db_xref="InterPro:IPR001094" /db_xref="InterPro:IPR001433" /db_xref="InterPro:IPR001709" /db_xref="InterPro:IPR003097" /db_xref="InterPro:IPR008254" /db_xref="InterPro:IPR010199" /db_xref="InterPro:IPR017927" /db_xref="InterPro:IPR017938" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG14100" /db_xref="UniProtKB/Swiss-Prot:O32214" /translation="MQLQVMNSPFNQEQAELLNRLLPTLTESQKIWLSGYLSAQSVSA QEAAGTPAAAVSAEAPAPAVSKEVTVLYGSQTGNAQGLAENAGKQLEQSGFQVTVSSM SDFKPNQLKKVTNLLIVVSTHGEGEPPDNALSFHEFLHGRRAPKLEDLRFSVLALGDS SYEFFCQTGKEFDQRLEELGGKRISPRVDCDLDYDEPAAEWLEGVLKGLNEAGGGSAA PAPAAASQTGESSYSRTNPFRAEVLENLNLNGRGSNKETRHVELSLEGSGLTYEPGDS LGVYPENDPELVELLLKEMNWDPEEIVTLNKQGDVRPLKEALISHYEITVLTKPLLEQ AAQLTGNDELRELLAPGNEENVKAYIEGRDLLDLVRDYGPFSVSAQEFVSILRKMPAR LYSIASSLSANPDEVHLTIGAVRYDAHGRERKGVCSILCAERLQPGDTLPVYVQHNQN FKLPKDPETPIIMVGPGTGVAPFRSFMQEREETGAEGKAWMFFGDQHFVTDFLYQTEW QNWLKDGVLTKMDVAFSRDTEEKVYVQHRMLEHSAELFEWLQEGAAVYICGDEKHMAH DVHNTLLEIIEKEGNMSREEAEAYLADMQQQKRYQRDVY*" /label="cysJ CDS" gene complement(3083453..3085270) /gene="cysJ" /locus_tag="BSU_33440" /old_locus_tag="BSU33440" /label="cysJ gene" promotor_-10 complement(3085312..3085331) /Source="Nicolas_upshift_promotors" /id="U2624" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.584415584415584" /psig="0.998001998001998" /xcortree=3070 /SigmaFactorBS="ttatcattaggattcttaatagttatcatcatgtaaatatAT TTTACTtaagcctagtatTCCGGTAAAGTTCAATTAGAtgcaattttcgatcagttta t" /listShort="cysJ, cysI, S1281, nhaK" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 3085321..3085328 /Source="Nicolas_upshift_promotors" /id="U2625" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.74925074925075" /psig="0.98001998001998" /xcortree=3037 /SigmaFactorBS="atccacctcacaaagttataaactgatcgaaaattgcatcta attgaACTTTACCggaatactaggcTTAAGTAAAATATATTTACAtgatgataactat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3085331) /Source="Nicolas_upshifts" /id="U2624" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.584415584415584" /psig="0.998001998001998" /xcortree=3070 /SigmaFactorBS="ttatcattaggattcttaatagttatcatcatgtaaatatAT TTTACTtaagcctagtatTCCGGTAAAGTTCAATTAGAtgcaattttcgatcagttta t" /listShort="cysJ, cysI, S1281, nhaK" /GFF_Attribute="listLong" /label="upshifts" upshifts 3085334 /Source="Nicolas_upshifts" /id="U2625" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.74925074925075" /psig="0.98001998001998" /xcortree=3037 /SigmaFactorBS="atccacctcacaaagttataaactgatcgaaaattgcatcta attgaACTTTACCggaatactaggcTTAAGTAAAATATATTTACAtgatgataactat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3085341..3085360 /Source="Nicolas_upshift_promotors" /id="U2625" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.74925074925075" /psig="0.98001998001998" /xcortree=3037 /SigmaFactorBS="atccacctcacaaagttataaactgatcgaaaattgcatcta attgaACTTTACCggaatactaggcTTAAGTAAAATATATTTACAtgatgataactat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3085344..3085351) /Source="Nicolas_upshift_promotors" /id="U2624" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.584415584415584" /psig="0.998001998001998" /xcortree=3070 /SigmaFactorBS="ttatcattaggattcttaatagttatcatcatgtaaatatAT TTTACTtaagcctagtatTCCGGTAAAGTTCAATTAGAtgcaattttcgatcagttta t" /listShort="cysJ, cysI, S1281, nhaK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3085441..3087765) /gene="helD" /locus_tag="BSU_33450" /old_locus_tag="BSU33450" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11544244, 24520113" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11544244, 24520113; Product type f: factor" /codon_start=1 /transl_table=11 /product="transcription factor" /protein_id="NP_391225.1" /db_xref="EnsemblGenomes-Gn:BSU33450" /db_xref="EnsemblGenomes-Tr:CAB15350" /db_xref="GOA:O32215" /db_xref="InterPro:IPR000212" /db_xref="InterPro:IPR014016" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR027785" /db_xref="SubtiList:BG14101" /db_xref="UniProtKB/Swiss-Prot:O32215" /translation="MNQQDKEWKEEQSRIDEVLKELEKKERFLETSAGGLKHDIIGLR KSFWEDVKVNFDDAHEAIETMASIKQQAELLSDREHNHRRMDQQLKRIHQLKKSPYFG RIDFIENGEEQAERIYIGLASCLDEKEEHFLIYDWRAPISSLYYNYSPGKAEYEVPGE TIEGEMVLKRQFMIKNGTLKAMFNTDMTIGDEMLQEVLSHHSDTQMKNIVSTIQKEQN QIIRNEKSKILIVQGAAGSGKTSAALQRVAYLLYRHRGVIDAGQIVLFSPNFLFNSYV SSVLPELGEENMEQATFQEYIEHRLGRKFKCESPFDQLEYCLTETKGGDFPTRLAGIT WKAGLSFQQFINEYVTRLSSEGMIFKNIIFRGQKLITKEQIQSYFYSLDQNHSIPNRM EQTAKWLLSELNKLEKKERRKDWVVHEAELLDKEDYLDVYKKLQERKRFSESTFNDYQ REQQLLAAIIVKKAFKPLKQAVRLLAFLDVTQLYLQLFSGWGGKFQHEKMDAIGELTR SAFTDNKLLYEDAAPFLYMQDLIEGRKKNTKIKHLFIDEAQDYSPFQMAYMRSIFPAA SMTVLGDINQSIYAHTINGDQRMDACFEDEPAEYVRLKRTYRSTRQIVEFTKAMLQDG ADIEPFNRSGEMPLVVKTEGHESLCQKLAQEIGRLKKKGHETIAVICKTAHQCIQAHA HMSEYTDVRLIHKENQPFQKGVCVIPVYLAKGIEFDAVLVYDASEEHYHTEHDRRLLY TACTRAMHMLAVFYTGEASPFVTAVPPHLYQIAE*" /label="helD CDS" gene complement(3085441..3087765) /gene="helD" /locus_tag="BSU_33450" /old_locus_tag="BSU33450" /label="helD gene" downshifts complement(3085459) /Source="Nicolas_upshifts" /id="D1736" /incds=0 /nref=26 /ntot=168 /MaxReadThrough="1.20405" /MaxDrop="4.59044" /score="18.6044234" /energy="-8.5" /TU="NA" /idTUdmin="U2628" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 3087785..3087792 /Source="Nicolas_upshift_promotors" /id="U2626" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.888111888111888" /psig=1 /xcortree=3099 /SigmaFactorBS="atcctgctgattcatgaacggcacctccagaaaaTAGTTGAC aaacatagatgaaaTACTGTAAAATATAATTGGAtacatatattaaatatatgatgca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3087807..3087826 /Source="Nicolas_upshift_promotors" /id="U2626" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.888111888111888" /psig=1 /xcortree=3099 /SigmaFactorBS="atcctgctgattcatgaacggcacctccagaaaaTAGTTGAC aaacatagatgaaaTACTGTAAAATATAATTGGAtacatatattaaatatatgatgca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" misc_feature complement(3087808..3087823) /Source="Nicolas_upshift_promotors" /id="U2627" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.276723276723277" /psig="0.398601398601399" /xcortree=685 /SigmaFactorBS="attataaattgtatttgccagtttgcatcatatatttaatat atgtatccAATTATATTTTACAGTatttcatctatgtttgtcaactattttctggagg t" /listShort="helD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3087811 /Source="Nicolas_upshifts" /id="U2626" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.888111888111888" /psig=1 /xcortree=3099 /SigmaFactorBS="atcctgctgattcatgaacggcacctccagaaaaTAGTTGAC aaacatagatgaaaTACTGTAAAATATAATTGGAtacatatattaaatatatgatgca a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(3087813) /Source="Nicolas_upshifts" /id="U2627" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.276723276723277" /psig="0.398601398601399" /xcortree=685 /SigmaFactorBS="attataaattgtatttgccagtttgcatcatatatttaatat atgtatccAATTATATTTTACAGTatttcatctatgtttgtcaactattttctggagg t" /listShort="helD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3087858..3087877) /Source="Nicolas_upshift_promotors" /id="U2628" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.380619380619381" /psig="0.993006993006993" /xcortree=1452 /SigmaFactorBS="ttttctgcataatataaataacccaaacCTTGATTggtattg ggtgaatgTGCTATTATAAATTGTATTTgccagtttgcatcatatatttaatatatgt a" /listShort="helD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3087867) /Source="Nicolas_upshifts" /id="U2628" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.380619380619381" /psig="0.993006993006993" /xcortree=1452 /SigmaFactorBS="ttttctgcataatataaataacccaaacCTTGATTggtattg ggtgaatgTGCTATTATAAATTGTATTTgccagtttgcatcatatatttaatatatgt a" /listShort="helD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3087893..3087899) /Source="Nicolas_upshift_promotors" /id="U2628" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.380619380619381" /psig="0.993006993006993" /xcortree=1452 /SigmaFactorBS="ttttctgcataatataaataacccaaacCTTGATTggtattg ggtgaatgTGCTATTATAAATTGTATTTgccagtttgcatcatatatttaatatatgt a" /listShort="helD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3087903..3087922) /Source="Nicolas_upshift_promotors" /id="U2629" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.854145854145854" /psig="0.854145854145854" /xcortree=1255 /SigmaFactorBS="tcttttcgcttagataattaatagcaaaaaaaccgatttCGA AGTGAAatcggtttttttcTGCATAATATAAATAACCCAaaccttgattggtattggg t" /listShort="helD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3087923) /Source="Nicolas_upshifts" /id="U2629" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.854145854145854" /psig="0.854145854145854" /xcortree=1255 /SigmaFactorBS="tcttttcgcttagataattaatagcaaaaaaaccgatttCGA AGTGAAatcggtttttttcTGCATAATATAAATAACCCAaaccttgattggtattggg t" /listShort="helD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3087936..3087944) /Source="Nicolas_upshift_promotors" /id="U2629" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.854145854145854" /psig="0.854145854145854" /xcortree=1255 /SigmaFactorBS="tcttttcgcttagataattaatagcaaaaaaaccgatttCGA AGTGAAatcggtttttttcTGCATAATATAAATAACCCAaaccttgattggtattggg t" /listShort="helD" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3087950) /Source="Nicolas_upshifts" /id="D1737" /incds=0 /nref=19 /ntot=158 /MaxReadThrough="2.30604" /MaxDrop="4.26839" /score="16.6103553" /energy="-9.2" /TU="NA" /idTUdmin="U2630" /TUdmin=17 /isTUend="TRUE" /label="downshifts" CDS complement(3087963..3088571) /gene="yvgT" /locus_tag="BSU_33460" /old_locus_tag="BSU33460" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_391226.1" /db_xref="EnsemblGenomes-Gn:BSU33460" /db_xref="EnsemblGenomes-Tr:CAB15351" /db_xref="GOA:O32216" /db_xref="InterPro:IPR005115" /db_xref="SubtiList:BG14102" /db_xref="UniProtKB/Swiss-Prot:O32216" /translation="MAWELLSVIGIIAFAVSGAIVAMEEEYDILGVYILGIVTAFGGG AIRNLLIGVPVSALWEQGAYFQIALLSITIVFLFPKLLLKHWNKWGNLSDAIGLAAFA IQGALYAVKMGHPLSAVIVAAVLTGSGGGIIRDLLAGRKPLVLKAEIYAVWAALGGLI VGLGWLGNSFGLYVLFFVLVVCRVCSYMFNWKLPNRSFRLDN*" /label="yvgT CDS" gene complement(3087963..3088571) /gene="yvgT" /locus_tag="BSU_33460" /old_locus_tag="BSU33460" /label="yvgT gene" promotor_-10 complement(3088610..3088629) /Source="Nicolas_upshift_promotors" /id="U2630" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.642357642357642" /psig=1 /xcortree=2617 /SigmaFactorBS="attccctctaaatttatctttttttctcatgaaaatgtTATT GattttacgctggagcGATTATAAAATCTAGAGGTCgtcagaaaatttaacaaacata a" /listShort="yvgT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3088627) /Source="Nicolas_upshifts" /id="U2630" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.642357642357642" /psig=1 /xcortree=2617 /SigmaFactorBS="attccctctaaatttatctttttttctcatgaaaatgtTATT GattttacgctggagcGATTATAAAATCTAGAGGTCgtcagaaaatttaacaaacata a" /listShort="yvgT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3088645..3088649) /Source="Nicolas_upshift_promotors" /id="U2630" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.642357642357642" /psig=1 /xcortree=2617 /SigmaFactorBS="attccctctaaatttatctttttttctcatgaaaatgtTATT GattttacgctggagcGATTATAAAATCTAGAGGTCgtcagaaaatttaacaaacata a" /listShort="yvgT" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3088758..3089174) /gene="bdbC" /locus_tag="BSU_33470" /old_locus_tag="BSU33470" /function="16.6: Maintain" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10455116, 11872755, 15661011, 15849754, 16751195, 16850406, 17088376" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10455116, 11872755, 15661011, 15849754, 16751195, 16850406, 17088376; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thiol-disulfide oxidoreductase" /protein_id="NP_391227.1" /db_xref="EnsemblGenomes-Gn:BSU33470" /db_xref="EnsemblGenomes-Tr:CAB15352" /db_xref="GOA:O32217" /db_xref="InterPro:IPR003752" /db_xref="InterPro:IPR012187" /db_xref="InterPro:IPR023380" /db_xref="SubtiList:BG14103" /db_xref="UniProtKB/Swiss-Prot:O32217" /translation="MKNRIVFLYASWVVALIAMLGSLYFSEIRKFIPCELCWYQRILM YPLVLILGIATFQGDTRVKKYVLPMAIIGAFISIMHYLEQKVPGFSGIKPCVSGVPCS GQYINWFGFITIPFLALIAFILIIIFMCLLKGEKSE*" /label="bdbC CDS" gene complement(3088758..3089174) /gene="bdbC" /locus_tag="BSU_33470" /old_locus_tag="BSU33470" /label="bdbC gene" downshifts complement(3088768) /Source="Nicolas_upshifts" /id="D1738" /incds=0 /nref=120 /ntot=264 /MaxReadThrough="1.31968" /MaxDrop="6.21723" /score="26.5991603" /energy="-12.7" /TU="NA" /idTUdmin="U2631" /TUdmin="-9" /isTUend="TRUE" /label="downshifts" CDS complement(3089179..3089847) /gene="bdbD" /locus_tag="BSU_33480" /old_locus_tag="BSU33480" /function="16.13: Shape" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11744713, 11872755, 12637552, 15661011, 17501922, 19535335" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11744713, 11872755, 12637552, 15661011, 17501922, 19535335; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="thiol-disulfide oxidoreductase" /protein_id="NP_391228.1" /db_xref="EnsemblGenomes-Gn:BSU33480" /db_xref="EnsemblGenomes-Tr:CAB15353" /db_xref="GOA:O32218" /db_xref="InterPro:IPR012336" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR036249" /db_xref="PDB:3EU3" /db_xref="PDB:3EU4" /db_xref="PDB:3GH9" /db_xref="PDB:3GHA" /db_xref="SubtiList:BG14104" /db_xref="UniProtKB/Swiss-Prot:O32218" /translation="MKKKQQSSAKFAVILTVVVVVLLAAIVIINNKTEQGNDAVSGQP SIKGQPVLGKDDAPVTVVEFGDYKCPSCKVFNSDIFPKIQKDFIDKGDVKFSFVNVMF HGKGSRLAALASEEVWKEDPDSFWDFHEKLFEKQPDTEQEWVTPGLLGDLAKSTTKIK PETLKENLDKETFASQVEKDSDLNQKMNIQATPTIYVNDKVIKNFADYDEIKETIEKE LKGK*" /label="bdbD CDS" gene complement(3089179..3089847) /gene="bdbD" /locus_tag="BSU_33480" /old_locus_tag="BSU33480" /label="bdbD gene" promotor_-10 complement(3089899..3089918) /Source="Nicolas_upshift_promotors" /id="U2631" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.414585414585415" /psig="0.998001998001998" /xcortree=2707 /SigmaFactorBS="acaaataaattgtcggagagaattcattttttcggggTTTTC TtatcagcgcttgtCTTGTTAAAATAAAGAAGTGggtcaattgcgatccgcttctttt t" /listShort="bdbD, bdbC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3089914) /Source="Nicolas_upshifts" /id="U2631" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.414585414585415" /psig="0.998001998001998" /xcortree=2707 /SigmaFactorBS="acaaataaattgtcggagagaattcattttttcggggTTTTC TtatcagcgcttgtCTTGTTAAAATAAAGAAGTGggtcaattgcgatccgcttctttt t" /listShort="bdbD, bdbC" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(3089925) /Source="Nicolas_upshifts" /id="D1739" /incds=0 /nref=3 /ntot=9 /MaxReadThrough="7.34296" /MaxDrop="3.6233" /score="12.4442247" /energy="-11.3" /TU="U2632" /idTUdmin="U2633" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 complement(3089932..3089937) /Source="Nicolas_upshift_promotors" /id="U2631" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.414585414585415" /psig="0.998001998001998" /xcortree=2707 /SigmaFactorBS="acaaataaattgtcggagagaattcattttttcggggTTTTC TtatcagcgcttgtCTTGTTAAAATAAAGAAGTGggtcaattgcgatccgcttctttt t" /listShort="bdbD, bdbC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3089967..3092075) /gene="cadA" /locus_tag="BSU_33490" /old_locus_tag="BSU33490" /EC_number="3.6.3.3" /EC_number="3.6.3.5" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7721839, 8037745, 11934502, 11922674, 12644235, 12779235, 14663075, 16901659" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7721839, 8037745, 11934502, 11922674, 12644235, 12779235, 14663075, 16901659; Product type t: transporter" /codon_start=1 /transl_table=11 /product="Cd(II), Zn(II) and Co(II) exporter (ATPase)" /protein_id="NP_391229.3" /db_xref="EnsemblGenomes-Gn:BSU33490" /db_xref="EnsemblGenomes-Tr:CAB15354" /db_xref="GOA:O32219" /db_xref="InterPro:IPR001757" /db_xref="InterPro:IPR006121" /db_xref="InterPro:IPR008250" /db_xref="InterPro:IPR017969" /db_xref="InterPro:IPR018303" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR023298" /db_xref="InterPro:IPR023299" /db_xref="InterPro:IPR027256" /db_xref="InterPro:IPR036163" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG14105" /db_xref="UniProtKB/Swiss-Prot:O32219" /translation="MRLVKQEYVLDGLDCSNCARKIENGVKGIKGINGCAVNFAASTL TVSADGKEEQWVTNKVEKKVKSIDPHVTVRQKHIKKSADDGYRNRMVNMLIRMAAAVI LGAAAYLVQSGTIEFFLFLGAYLIIGGDIIIRAVKNIIRGQVFDEHFLMALATIGAFL IQQYPEGVAVMLFYQIGELFQGAAVSRSRKSISALMDIRPDYANLKTKNGIEQVSSED VQTGDIIVVNPGESIPLDGKVVQGSAMVDTSALTGESVPRKAAEGQDVMSGFINQNGV LHIEVTKGYQESAVSKILDLVQNASSRKARTENFITKFAKYYTPAVVIIAVLLAFVPP LVLSGAALSDWVYRALIFLVISCPCALVVSIPLGFFGGIGAASKAGVLVKGSNYLEAL NQVKYAVFDKTGTLTKGSFEVTEIKPAEGFTKDRLLEAAAYAELHSQHPIAESVRKAY GKMLSSDEIESYEEISGHGIFAKVNGTEILAGNKKLMEREQIEDVPDENAGTIVHVAV DQRYAGAIIIADEIKEDAAQAVADLKSLGIKQTAMLTGDSKQTGEAVGKQLGIGEVYA ELLPQDKVAQVEALEAKLLPSEKLIFVGDGINDTPVLARADIGVAMGGLGSDAAVEAA DIVLMTDQPSKIAEAIRIAKRTRRIVWQNIGFALGVKAIFLILGAFGIATMWEAVFSD VGVTLLAVANAMRVMRLKNK*" /label="cadA CDS" gene complement(3089967..3092075) /gene="cadA" /locus_tag="BSU_33490" /old_locus_tag="BSU33490" /label="cadA gene" S_feature complement(3092067..3092168) /Source="Nicolas_S_feature" /locus_tag="new_3440953_3441054_c" /HighExp="dia5, LBGtran, LBGstat, Diami, LBGexp, Gly, Lbtran, T0.30H, M40t45, M0t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.982, 0.999" /TUlongSig="SigB" /TUlongPSig="0.587" /label="S1282" promotor_-10 complement(3092162..3092181) /Source="Nicolas_upshift_promotors" /id="U2632" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.576423576423576" /psig="0.982017982017982" /xcortree=1542 /SigmaFactorBS="ggctatatgccggtttttgtttttCATTGACActttcttgga aaacaACATATAATAGGTGTAACTTatatatgagtatatgctcatatatataaaataa a" /listShort="S1282, copB, bdbD, bdbC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3092168) /Source="Nicolas_upshifts" /id="U2632" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.576423576423576" /psig="0.982017982017982" /xcortree=1542 /SigmaFactorBS="ggctatatgccggtttttgtttttCATTGACActttcttgga aaacaACATATAATAGGTGTAACTTatatatgagtatatgctcatatatataaaataa a" /listShort="S1282, copB, bdbD, bdbC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3092197..3092204) /Source="Nicolas_upshift_promotors" /id="U2632" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.576423576423576" /psig="0.982017982017982" /xcortree=1542 /SigmaFactorBS="ggctatatgccggtttttgtttttCATTGACActttcttgga aaacaACATATAATAGGTGTAACTTatatatgagtatatgctcatatatataaaataa a" /listShort="S1282, copB, bdbD, bdbC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3092235..3094643) /gene="copA" /locus_tag="BSU_33500" /old_locus_tag="BSU33500" /EC_number="3.6.3.54" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11922674, 11934502, 12644235, 14663075, 18215122, 19378562, 19751213, 20233928, 22077885, 22531974" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11922674, 11934502, 12644235, 14663075, 18215122, 19378562, 19751213, 20233928, 22077885, 22531974; Product type t : transporter" /codon_start=1 /transl_table=11 /product="copper transporter ATPase" /protein_id="NP_391230.2" /db_xref="EnsemblGenomes-Gn:BSU33500" /db_xref="EnsemblGenomes-Tr:CAB15355" /db_xref="GOA:O32220" /db_xref="InterPro:IPR001757" /db_xref="InterPro:IPR006121" /db_xref="InterPro:IPR006122" /db_xref="InterPro:IPR008250" /db_xref="InterPro:IPR017969" /db_xref="InterPro:IPR018303" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR023298" /db_xref="InterPro:IPR023299" /db_xref="InterPro:IPR027256" /db_xref="InterPro:IPR036163" /db_xref="InterPro:IPR036412" /db_xref="PDB:1JWW" /db_xref="PDB:1KQK" /db_xref="PDB:1OPZ" /db_xref="PDB:1OQ3" /db_xref="PDB:1OQ6" /db_xref="PDB:1P6T" /db_xref="PDB:2RML" /db_xref="PDB:2VOY" /db_xref="SubtiList:BG14106" /db_xref="UniProtKB/Swiss-Prot:O32220" /translation="MSEQKEIAMQVSGMTCAACAARIEKGLKRMPGVTDANVNLATET SNVIYDPAETGTAAIQEKIEKLGYHVVTEKAEFDIEGMTCAACANRIEKRLNKIEGVA NAPVNFALETVTVEYNPKEASVSDLKEAVDKLGYKLKLKGEQDSEAAAKKKEERKQTA RLIFSAVLSFPLLWAMVSHFTFTSFIWVPDIFLNPWMQFALATPVQFLIGWPFYVGAY KALRNKSANMDVLVALGTTAAYAYSLYLTFQSIGSHGHTDGLYYETSAILLTLILLGK LFETKAKGRSSDAIKKLMKLQAKTATVVRDGQEQIIPIDEVLVNDIVYVKPGERIPVD GEVVEGRSAVDESMITGESLPVDKNPGDSVTGSTVNANGFLKIKAVNVGKDTALSHII KIVEEAQGSKAPIQRLADQISGIFVPIVLGIAVLTFLIWYLWAAPGDFAEAISKFIAV LVIACPCALGLATPTSIMAGSGRAAEFGILFKGGEHLEKTHRLDTIVLDKTGTVTNGK PRLTDAIPFGRFEEKDLLQFAAAAETGSEHPLGEAIIAGVKDKGLEIPKLTRFEAKVG AGILAEAGGKSILVGTRKLMESEQVEHGALLAQMEELEAEGKTVMLVSIDGEAAGLVA VADTIKDTSRKAVARLKELGLDVIMMTGDNRRTAEAIAKEAGIANIIAEVLPEQKAAE IARLQKEGRQTAMVGDGINDAPALATADIGMAIGTGTDIAMETADITLIRGDLNSIAD AIRMSRLTMKNIKQNLFWALGYNSLGIPIAALGFLAPWIAGAAMAFSSVSVVLNALRL QKVK*" /label="copA CDS" gene complement(3092235..3094643) /gene="copA" /locus_tag="BSU_33500" /old_locus_tag="BSU33500" /label="copA gene" downshifts complement(3092257) /Source="Nicolas_upshifts" /id="D1740" /incds=0 /nref=15 /ntot=68 /MaxReadThrough="5.02116" /MaxDrop="3.63756" /score="26.9828242" /energy="-7.9" /TU="U2633" /idTUdmin="U2635" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(3092323) /Source="Nicolas_upshifts" /id="D1741" /incds=1 /nref=52 /ntot=227 /MaxReadThrough="5.93949" /MaxDrop="4.28993" /score="26.9828242" /energy="-7.9" /TU="U2633,U2635" /idTUdmin="U2635" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" S_feature complement(3094644..3094726) /Source="Nicolas_S_feature" /locus_tag="new_3443530_3443612_c" /HighExp="Diami, dia5, dia15, Gly, T0.30H, Heat, T1.0H, T1.30H, T0.0H, LPhT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="0.999, 0.587" /TUlongSig="NA" /TUlongPSig="NA" /label="S1283" CDS complement(3094727..3094936) /gene="copZ" /locus_tag="BSU_33510" /old_locus_tag="BSU33510" /function="16.1: Circulate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11934502, 12238948, 12590580, 14621987, 14663075, 15212800, 18419582, 27197762, 28078344" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11934502, 12238948, 12590580, 14621987, 14663075, 15212800, 18419582, 27197762, 28078344; Product type f: factor" /codon_start=1 /transl_table=11 /product="copper insertion chaperone and transporter component" /protein_id="NP_391231.1" /db_xref="EnsemblGenomes-Gn:BSU33510" /db_xref="EnsemblGenomes-Tr:CAB15356" /db_xref="GOA:O32221" /db_xref="InterPro:IPR000428" /db_xref="InterPro:IPR006121" /db_xref="InterPro:IPR006122" /db_xref="InterPro:IPR017969" /db_xref="InterPro:IPR036163" /db_xref="PDB:1K0V" /db_xref="PDB:1P8G" /db_xref="PDB:2QIF" /db_xref="PDB:3I9Z" /db_xref="SubtiList:BG14107" /db_xref="UniProtKB/Swiss-Prot:O32221" /translation="MEQKTLQVEGMSCQHCVKAVETSVGELDGVSAVHVNLEAGKVDV SFDADKVSVKDIADAIEDQGYDVAK*" /label="copZ CDS" gene complement(3094727..3094936) /gene="copZ" /locus_tag="BSU_33510" /old_locus_tag="BSU33510" /label="copZ gene" promotor_-10 complement(3094960..3094979) /Source="Nicolas_upshift_promotors" /id="U2633" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.74925074925075" /psig="0.999000999001" /xcortree=1766 /SigmaFactorBS="tggacgtatttaaaaagttcacaaaatcataaagcgtttttt aTTGTAATaccctacgggggTATGGTAGGATGAAAATAGAaagaataaacaggaggaa t" /listShort="copZ, S1283, copA, S1282, copB" /listLong="bdbD, bdbC" /label="promotor_-10" upshifts complement(3094981) /Source="Nicolas_upshifts" /id="U2633" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.74925074925075" /psig="0.999000999001" /xcortree=1766 /SigmaFactorBS="tggacgtatttaaaaagttcacaaaatcataaagcgtttttt aTTGTAATaccctacgggggTATGGTAGGATGAAAATAGAaagaataaacaggaggaa t" /listShort="copZ, S1283, copA, S1282, copB" /listLong="bdbD, bdbC" /label="upshifts" promotor_-35 complement(3094992..3094998) /Source="Nicolas_upshift_promotors" /id="U2633" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.74925074925075" /psig="0.999000999001" /xcortree=1766 /SigmaFactorBS="tggacgtatttaaaaagttcacaaaatcataaagcgtttttt aTTGTAATaccctacgggggTATGGTAGGATGAAAATAGAaagaataaacaggaggaa t" /listShort="copZ, S1283, copA, S1282, copB" /listLong="bdbD, bdbC" /label="promotor_-35" CDS complement(3095010..3095315) /gene="csoR" /locus_tag="BSU_33520" /old_locus_tag="BSU33520" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17143269, 18048925, 22904286, 24831014, 25209494" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17143269, 18048925, 22904286, 24831014, 25209494; Product type r: regulator" /codon_start=1 /transl_table=11 /product="repressor of copper utilisation proteins-Cu(I)" /protein_id="NP_391232.1" /db_xref="EnsemblGenomes-Gn:BSU33520" /db_xref="EnsemblGenomes-Tr:CAB15357" /db_xref="GOA:O32222" /db_xref="InterPro:IPR003735" /db_xref="SubtiList:BG14108" /db_xref="UniProtKB/Swiss-Prot:O32222" /translation="MEKHNEHKTLNHKSSKEKDQITNRLKRIEGQVRGIQNMVENDRY CVDILVQISAVQAAMKNVALHLLEDHAHHCVADAIKSGDGEQAISELLDVFKKFTKS* " /label="csoR CDS" gene complement(3095010..3095315) /gene="csoR" /locus_tag="BSU_33520" /old_locus_tag="BSU33520" /label="csoR gene" misc_feature 3095279..3095298 /Source="Nicolas_upshift_promotors" /id="U2634" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.877122877122877" /psig="0.986013986013986" /xcortree=2475 /SigmaFactorBS="tcaatccgcttaagccggtttgtaatctgatccttttctttc gagctttTATGGTTTAATGTTTTATGTtcgttatgcttttccatgcgtacacctctgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3095290 /Source="Nicolas_upshifts" /id="U2634" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.877122877122877" /psig="0.986013986013986" /xcortree=2475 /SigmaFactorBS="tcaatccgcttaagccggtttgtaatctgatccttttctttc gagctttTATGGTTTAATGTTTTATGTtcgttatgcttttccatgcgtacacctctgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3095329..3095348) /Source="Nicolas_upshift_promotors" /id="U2635" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.587412587412587" /psig="0.587412587412587" /xcortree=130 /SigmaFactorBS="ggtaaaacctaactgattcattttttgcgtcggcatgcttag acaacCGTTTGGacaatcagtataaTGGGAATTAATATCATTAAAcagaggtgtacgc a" /listShort="csoR, copZ, S1283, copA" /listLong="S1282, copB, bdbD, bdbC" /label="promotor_-10" upshifts complement(3095355) /Source="Nicolas_upshifts" /id="U2635" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.587412587412587" /psig="0.587412587412587" /xcortree=130 /SigmaFactorBS="ggtaaaacctaactgattcattttttgcgtcggcatgcttag acaacCGTTTGGacaatcagtataaTGGGAATTAATATCATTAAAcagaggtgtacgc a" /listShort="csoR, copZ, S1283, copA" /listLong="S1282, copB, bdbD, bdbC" /label="upshifts" promotor_-35 complement(3095362..3095368) /Source="Nicolas_upshift_promotors" /id="U2635" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.587412587412587" /psig="0.587412587412587" /xcortree=130 /SigmaFactorBS="ggtaaaacctaactgattcattttttgcgtcggcatgcttag acaacCGTTTGGacaatcagtataaTGGGAATTAATATCATTAAAcagaggtgtacgc a" /listShort="csoR, copZ, S1283, copA" /listLong="S1282, copB, bdbD, bdbC" /label="promotor_-35" promotor_-35 3095407..3095413 /Source="Nicolas_upshift_promotors" /id="U2636" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.952047952047952" /psig="0.952047952047952" /xcortree=133 /SigmaFactorBS="aagcatgccgacgcaaaaaatgaatcagttaGGTTTTAccat ttgatcaggaGGGTATATACTTCTGTTGAtaacgcttttaaaggggagaagaaaagtg g" /listShort="yvaA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3095428..3095446 /Source="Nicolas_upshift_promotors" /id="U2636" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.952047952047952" /psig="0.952047952047952" /xcortree=133 /SigmaFactorBS="aagcatgccgacgcaaaaaatgaatcagttaGGTTTTAccat ttgatcaggaGGGTATATACTTCTGTTGAtaacgcttttaaaggggagaagaaaagtg g" /listShort="yvaA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3095436 /Source="Nicolas_upshifts" /id="U2636" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.952047952047952" /psig="0.952047952047952" /xcortree=133 /SigmaFactorBS="aagcatgccgacgcaaaaaatgaatcagttaGGTTTTAccat ttgatcaggaGGGTATATACTTCTGTTGAtaacgcttttaaaggggagaagaaaagtg g" /listShort="yvaA" /GFF_Attribute="listLong" /label="upshifts" CDS 3095443..3096519 /gene="iolW" /locus_tag="BSU_33530" /old_locus_tag="BSU33530" /EC_number="1.1.1.371" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:15937154, 20133360, 28693424" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15937154, 20133360, 28693424; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="scyllo-inositol 2-dehydrogenase (NADP(+)-dependent)" /protein_id="NP_391233.1" /db_xref="EnsemblGenomes-Gn:BSU33530" /db_xref="EnsemblGenomes-Tr:CAB15358" /db_xref="GOA:O32223" /db_xref="InterPro:IPR000683" /db_xref="InterPro:IPR004104" /db_xref="InterPro:IPR036291" /db_xref="PDB:3GDO" /db_xref="PDB:3GFG" /db_xref="SubtiList:BG14057" /db_xref="UniProtKB/Swiss-Prot:O32223" /translation="MITLLKGRRKVDTIKVGILGYGLSGSVFHGPLLDVLDEYQISKI MTSRTEEVKRDFPDAEVVHELEEITNDPAIELVIVTTPSGLHYEHTMACIQAGKHVVM EKPMTATAEEGETLKRAADEKGVLLSVYHNRRWDNDFLTIKKLISEGSLEDINTYQVS YNRYRPEVQARWREKEGTATGTLYDLGSHIIDQTLHLFGMPKAVTANVMAQRENAETV DYFHLTLDYGKLQAILYGGSIVPANGPRYQIHGKDSSFIKYGIDGQEDALRAGRKPED DSWGADVPEFYGKLTTIRGSDKKTETIPSVNGSYLTYYRKIAESIREGAALPVTAEEG INVIRIIEAAMESSKEKRTIMLEH*" /label="iolW CDS" gene 3095443..3096519 /gene="iolW" /locus_tag="BSU_33530" /old_locus_tag="BSU33530" /label="iolW gene" downshifts 3096506 /Source="Nicolas_upshifts" /id="D1742" /incds=0 /nref=155 /ntot=248 /MaxReadThrough="2.17322" /MaxDrop="6.48885" /score="-5.36701412" /energy="-19.4" /TU="NA" /idTUdmin="U2636" /TUdmin="-9" /isTUend="TRUE" /label="downshifts" CDS complement(3096556..3097191) /gene="azoRB" /locus_tag="BSU_33540" /old_locus_tag="BSU33540" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:17284825, 17725564, 18208493" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17284825, 17725564, 18208493; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NADH:dichloroindophenol oxidoreductase (2-methylhydroquinone resistance)" /protein_id="NP_391234.1" /db_xref="EnsemblGenomes-Gn:BSU33540" /db_xref="EnsemblGenomes-Tr:CAB15359" /db_xref="GOA:O32224" /db_xref="InterPro:IPR003680" /db_xref="InterPro:IPR023048" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG14058" /db_xref="UniProtKB/Swiss-Prot:O32224" /translation="MAKVLYITAHPHDEATSYSMATGKAFIESYKEANPNDEVVHIDL YKENIPHIDADVFSGWGKLQSGTGFEELSESEKAKVGRLGELSDQFASADKYVFVTPL WNFSFPPVMKAYLDSVAVAGKSFKYTEQGPVGLLTDKKAIHIQARGGYYSEGPAAEME MGHRYIGIMMNFFGVPSFDGIFVEGHNAEPDKAQQIKEDAIARAKEAGKTF*" /label="azoRB CDS" gene complement(3096556..3097191) /gene="azoRB" /locus_tag="BSU_33540" /old_locus_tag="BSU33540" /label="azoRB gene" downshifts complement(3096569) /Source="Nicolas_upshifts" /id="D1743" /incds=0 /nref=211 /ntot=263 /MaxReadThrough="1.58189" /MaxDrop="6.89477" /score="31.0885268" /energy="-15.4" /TU="NA" /idTUdmin="U2637" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(3097192..3097289) /Source="Nicolas_S_feature" /locus_tag="new_3446078_3446175_c" /HighExp="Heat, UNK1, G/S, Salt, HiTm, GM-0.1, MG 25, SMM, Etha, Glucon" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1284" promotor_-10 complement(3097269..3097288) /Source="Nicolas_upshift_promotors" /id="U2637" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.431568431568432" /psig=1 /xcortree=3022 /SigmaFactorBS="ctgtttgggaaagttaaataatctttaattcgagatgttttA CTTGAAagtaaatttctttGTCTCTATAATAAAGTCTAAgagagacagaataatcatt a" /listShort="S1284, yvaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3097289) /Source="Nicolas_upshifts" /id="U2637" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.431568431568432" /psig=1 /xcortree=3022 /SigmaFactorBS="ctgtttgggaaagttaaataatctttaattcgagatgttttA CTTGAAagtaaatttctttGTCTCTATAATAAAGTCTAAgagagacagaataatcatt a" /listShort="S1284, yvaB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3097302..3097308) /Source="Nicolas_upshift_promotors" /id="U2637" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.431568431568432" /psig=1 /xcortree=3022 /SigmaFactorBS="ctgtttgggaaagttaaataatctttaattcgagatgttttA CTTGAAagtaaatttctttGTCTCTATAATAAAGTCTAAgagagacagaataatcatt a" /listShort="S1284, yvaB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3097351..3099246) /gene="yvaC" /locus_tag="BSU_33550" /old_locus_tag="BSU33550" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12107147, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391235.1" /db_xref="EnsemblGenomes-Gn:BSU33550" /db_xref="EnsemblGenomes-Tr:CAB15360" /db_xref="GOA:O32225" /db_xref="SubtiList:BG14059" /db_xref="UniProtKB/Swiss-Prot:O32225" /translation="MNKTAANNQRIMPIVKDAFRIHANPFPWKKAIGSGFASGFPVLV GALAGHTDYGLIASIGGFVYLYAGGESYKKRALKLLLVSIGIALSFGLGTLLSGMLWM MAAVLGLIGAAAMFIFSALGIQGPAPMFFVLAFLVSSGLPADPSQALFRAGLTFLGGI FAMGIALIGWLWNKHGPEGAVLQKTYHQLAACLSAVGTPGFHNAQHQTVLMLRTARQT VLGKGNRRKKSRHDERFFRLLEKADDIFIAIIHFSAETPDRETAQIEKALRQTGDMLA NARVFNTFQINENESEPRRKLFEEINEVLYIASGRFDKQLDGEPSRLPSSFYFLRNAF DWKSPVLIRALKYGIVLFAADMFALAFGFARSYWIPLSAAAVMLGTTVVFTLHRAIQR SAGTVIGVILAGAILFFKPGGVYIAFCIAALQCLLEMLIVRNYALAVPFLTANALVIT ESMHGGAGAGYFMIARLTDVAVGSVIGLLGTMLLWRRFSTKRLPELVRNVIRLEGQFM EKLLTGQIADEHKLRVSLVRLRDAYDKALGEFPHANADALWPAISGAQHLGYYLLSAQ AHRRPSAPFSDEEINQLRAFFEQAEQSFIMKRMPADIQVPHVPHYPRISKELSALYSG LRTAFEK*" /label="yvaC CDS" gene complement(3097351..3099246) /gene="yvaC" /locus_tag="BSU_33550" /old_locus_tag="BSU33550" /label="yvaC gene" promotor_-10 complement(3099297..3099308) /Source="Nicolas_upshift_promotors" /id="U2638" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=869 /SigmaFactorBS="tctctgtttttttatcgtgcgcaccaatTGAGAAGctaaccg cgtttttGGGCATACTAAAgcgaagaaactggaaaagttctacacattcattgaaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3099297) /Source="Nicolas_upshifts" /id="U2638" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=869 /SigmaFactorBS="tctctgtttttttatcgtgcgcaccaatTGAGAAGctaaccg cgtttttGGGCATACTAAAgcgaagaaactggaaaagttctacacattcattgaaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3099323..3099329) /Source="Nicolas_upshift_promotors" /id="U2638" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=869 /SigmaFactorBS="tctctgtttttttatcgtgcgcaccaatTGAGAAGctaaccg cgtttttGGGCATACTAAAgcgaagaaactggaaaagttctacacattcattgaaaag g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3099396) /Source="Nicolas_upshifts" /id="D1744" /incds=0 /nref=20 /ntot=155 /MaxReadThrough="2.49984" /MaxDrop="4.21522" /score="11.4033831" /energy="-8" /TU="NA" /idTUdmin="U2639" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" CDS complement(3099409..3099810) /gene="yvaD" /locus_tag="BSU_33560" /old_locus_tag="BSU33560" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391236.1" /db_xref="EnsemblGenomes-Gn:BSU33560" /db_xref="EnsemblGenomes-Tr:CAB15361" /db_xref="GOA:O32226" /db_xref="InterPro:IPR020348" /db_xref="SubtiList:BG14060" /db_xref="UniProtKB/Swiss-Prot:O32226" /translation="MRYMKLFFLVTDIGFILYWLSAGFSLIPESWAFKHHDHPFMIAW NWSFFPLDILISVTGLYSLYLQRVNRADWKLMALISLVLTCCSGLQALSFWTFSSDFD LVWWLFNGYLLIYPLFFIHLLLKEGRRTKQS*" /label="yvaD CDS" gene complement(3099409..3099810) /gene="yvaD" /locus_tag="BSU_33560" /old_locus_tag="BSU33560" /label="yvaD gene" CDS complement(3099807..3100166) /gene="yvaE" /locus_tag="BSU_33570" /old_locus_tag="BSU33570" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11948170, 15849754, 16850406, 19549332; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative metabolite-efflux transporter" /protein_id="NP_391237.1" /db_xref="EnsemblGenomes-Gn:BSU33570" /db_xref="EnsemblGenomes-Tr:CAB15362" /db_xref="GOA:O32227" /db_xref="InterPro:IPR000390" /db_xref="SubtiList:BG14061" /db_xref="UniProtKB/Swiss-Prot:O32227" /translation="MNWVFLCLAILFEVAGTVSMKLSSGFTKLIPSLLLIFFYGGSLF FLTLTLKSIDVSVAYAVWSGMGIVLITVVGFLFFQEHVSVMKVISIGLIIAGVVSLNL IEHVAVSEPVHKSGQYK*" /label="yvaE CDS" gene complement(3099807..3100166) /gene="yvaE" /locus_tag="BSU_33570" /old_locus_tag="BSU33570" /label="yvaE gene" CDS complement(3100163..3100735) /gene="yvaF" /locus_tag="BSU_33580" /old_locus_tag="BSU33580" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_391238.1" /db_xref="EnsemblGenomes-Gn:BSU33580" /db_xref="EnsemblGenomes-Tr:CAB15363" /db_xref="GOA:O32228" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036271" /db_xref="SubtiList:BG14062" /db_xref="UniProtKB/Swiss-Prot:O32228" /translation="MDKRILAETFRLIKQKGFSFTMNDLAAALGTSKRTLYAYYSSKD QLVEAVVEQFIAEMKQIERDIYENESLNVLEKVKQMLISLPQGMELLNMGLLNELKKY HYDAWLTLDAFIKEEWAIVLALLNECKQQKRIRNINPDLFVHMYIGSINQVYDPEYPL KHQFTTGEVLESIVDVLFNGITADEEADAT*" /label="yvaF CDS" gene complement(3100163..3100735) /gene="yvaF" /locus_tag="BSU_33580" /old_locus_tag="BSU33580" /label="yvaF gene" promotor_-10 complement(3100773..3100792) /Source="Nicolas_upshift_promotors" /id="U2639" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig=1 /xcortree=2445 /SigmaFactorBS="ccaataggagaggtttttttatataTTGTTGATttccataaa tttcTGCCGTATAATATTGGTACCgaaatagttttcttggtaccgaaagcgggggatt a" /listShort="yvaF, yvaE, yvaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3100778) /Source="Nicolas_upshifts" /id="U2639" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig=1 /xcortree=2445 /SigmaFactorBS="ccaataggagaggtttttttatataTTGTTGATttccataaa tttcTGCCGTATAATATTGGTACCgaaatagttttcttggtaccgaaagcgggggatt a" /listShort="yvaF, yvaE, yvaD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3100806..3100813) /Source="Nicolas_upshift_promotors" /id="U2639" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.661338661338661" /psig=1 /xcortree=2445 /SigmaFactorBS="ccaataggagaggtttttttatataTTGTTGATttccataaa tttcTGCCGTATAATATTGGTACCgaaatagttttcttggtaccgaaagcgggggatt a" /listShort="yvaF, yvaE, yvaD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3100846..3101640) /gene="yvaG" /locus_tag="BSU_33590" /old_locus_tag="BSU33590" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391239.1" /db_xref="EnsemblGenomes-Gn:BSU33590" /db_xref="EnsemblGenomes-Tr:CAB15364" /db_xref="GOA:O32229" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG14063" /db_xref="UniProtKB/Swiss-Prot:O32229" /translation="MKLNLQGKTALVTGSTSGIGKAIASSLAEEGAAVIINGRREEKV NQTIDELKTQHAEAVLYPAAFDLGTEEGCNELFQAYPEVDILVNNLGIFEPAEYFDIP DDEWFRFFEVNIMSGVRLTRRYLHNMIEKKEGRVIFIASEAAIMPSQEMAHYSATKTM QLSISRSLAELATGTNVTVNTVMPGSTLTEGVETMLNSLYPGENLTVQEAEARFMKEN RPTSIIQRLIRPEEIAHFVTFLSSPLSSAINGAALRADGGLVRSVF*" /label="yvaG CDS" gene complement(3100846..3101640) /gene="yvaG" /locus_tag="BSU_33590" /old_locus_tag="BSU33590" /label="yvaG gene" promotor_-10 complement(3101661..3101679) /Source="Nicolas_upshift_promotors" /id="U2640" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.98101898101898" /psig="0.98101898101898" /xcortree=725 /SigmaFactorBS="atcccagctgtttcatactgattgcagagcagaTGTTTCAcc aatcagatttctGTCAATAAATAAGAGGAATcaaaaacggagggatgaataatgaagc t" /listShort="yvaG, yvaF, yvaE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3101673) /Source="Nicolas_upshifts" /id="U2640" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.98101898101898" /psig="0.98101898101898" /xcortree=725 /SigmaFactorBS="atcccagctgtttcatactgattgcagagcagaTGTTTCAcc aatcagatttctGTCAATAAATAAGAGGAATcaaaaacggagggatgaataatgaagc t" /listShort="yvaG, yvaF, yvaE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3101694..3101700) /Source="Nicolas_upshift_promotors" /id="U2640" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.98101898101898" /psig="0.98101898101898" /xcortree=725 /SigmaFactorBS="atcccagctgtttcatactgattgcagagcagaTGTTTCAcc aatcagatttctGTCAATAAATAAGAGGAATcaaaaacggagggatgaataatgaagc t" /listShort="yvaG, yvaF, yvaE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3101706..3101725) /Source="Nicolas_upshift_promotors" /id="U2641" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.866133866133866" /psig="0.94005994005994" /xcortree=2724 /SigmaFactorBS="tttctccaaaccacaggcaccaaaaagtgcgTACTTCCAttt caatcccagcTGTTTCATACTGATTGCAGAgcagatgtttcaccaatcagatttctgt c" /listShort="yvaG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3101717) /Source="Nicolas_upshifts" /id="U2641" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.866133866133866" /psig="0.94005994005994" /xcortree=2724 /SigmaFactorBS="tttctccaaaccacaggcaccaaaaagtgcgTACTTCCAttt caatcccagcTGTTTCATACTGATTGCAGAgcagatgtttcaccaatcagatttctgt c" /listShort="yvaG" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3101719..3101784) /Source="Nicolas_S_feature" /locus_tag="new_3450605_3450670_c" /HighExp="H2O2, Heat, Diami, G180, Paraq, dia15, Oxctl, BMM, G135, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.47, 0.997" /TUlongSig="SigA, SigA" /TUlongPSig="0.996, 1" /label="S1285" promotor_-35 complement(3101739..3101746) /Source="Nicolas_upshift_promotors" /id="U2641" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.866133866133866" /psig="0.94005994005994" /xcortree=2724 /SigmaFactorBS="tttctccaaaccacaggcaccaaaaagtgcgTACTTCCAttt caatcccagcTGTTTCATACTGATTGCAGAgcagatgtttcaccaatcagatttctgt c" /listShort="yvaG" /GFF_Attribute="listLong" /label="promotor_-35" misc_RNA complement(3101826..3102185) /gene="ssrA" /locus_tag="BSU_misc_RNA_55" /product="transfer-messenger RNA (tmRNA, 10Sa RNA)" /experiment="publication(s) with functional evidences, PMID:11395451, 11918677, 14766921, 17369301, 18673456" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11395451, 11918677, 14766921, 17369301, 18673456" /label="ssrA RNA" gene complement(3101826..3102185) /gene="ssrA" /locus_tag="BSU_misc_RNA_55" /label="ssrA gene" downshifts complement(3101829) /Source="Nicolas_upshifts" /id="D1745" /incds=0 /nref=260 /ntot=272 /MaxReadThrough="4.32959" /MaxDrop="9.81359" /score="26.7868133" /energy="-15.8" /TU="U2642,U2644" /idTUdmin="U2643" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3102169..3102177) /Source="Nicolas_upshift_promotors" /id="U2642" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.46953046953047" /psig="0.46953046953047" /xcortree=677 /SigmaFactorBS="atagccagtttgagtgagagcttgatattttctcccgtattt CCCTTAtaccaaggggacgtTACGGATTCgacagggatggatcgagcttgagctgcga g" /listShort="ssrA, S1285, yvaG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3102179) /Source="Nicolas_upshifts" /id="U2642" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.46953046953047" /psig="0.46953046953047" /xcortree=677 /SigmaFactorBS="atagccagtttgagtgagagcttgatattttctcccgtattt CCCTTAtaccaaggggacgtTACGGATTCgacagggatggatcgagcttgagctgcga g" /listShort="ssrA, S1285, yvaG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3102192..3102197) /Source="Nicolas_upshift_promotors" /id="U2642" /multdbtbs="-" /comp="M2" /sig="Sig-" /pcomp="0.46953046953047" /psig="0.46953046953047" /xcortree=677 /SigmaFactorBS="atagccagtttgagtgagagcttgatattttctcccgtattt CCCTTAtaccaaggggacgtTACGGATTCgacagggatggatcgagcttgagctgcga g" /listShort="ssrA, S1285, yvaG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3102237..3102256) /Source="Nicolas_upshift_promotors" /id="U2643" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.563436563436563" /psig="0.999000999001" /xcortree=1661 /SigmaFactorBS="tcacgacgccattcatttgaaggatttgacaaTTGAAaagag ccgtgatCATGTTATAATAAGACTATAgccagtttgagtgagagcttgatattttctc c" /listShort="ssrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3102245) /Source="Nicolas_upshifts" /id="U2643" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.563436563436563" /psig="0.999000999001" /xcortree=1661 /SigmaFactorBS="tcacgacgccattcatttgaaggatttgacaaTTGAAaagag ccgtgatCATGTTATAATAAGACTATAgccagtttgagtgagagcttgatattttctc c" /listShort="ssrA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3102247..3102311) /Source="Nicolas_S_feature" /locus_tag="new_3451133_3451197_c" /HighExp="Etha, C90, dia5, dia15, Diami, T0.0H, T-0.40H, T-1.40H, LPhT, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.997, 0.996, 1" /TUlongSig="SigB, SigA" /TUlongPSig="0.999, 0.753" /label="S1286" promotor_-35 complement(3102269..3102273) /Source="Nicolas_upshift_promotors" /id="U2643" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.563436563436563" /psig="0.999000999001" /xcortree=1661 /SigmaFactorBS="tcacgacgccattcatttgaaggatttgacaaTTGAAaagag ccgtgatCATGTTATAATAAGACTATAgccagtttgagtgagagcttgatattttctc c" /listShort="ssrA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3102311) /Source="Nicolas_upshifts" /id="U2644" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.701298701298701" /psig="0.997002997002997" /xcortree=1911 /SigmaFactorBS="aggcttctaaaggcatagTGCTTGATtcgaaaatcaggccTG TGCTATACTGTGTTCACGatcagatcacgacgccattcatttgaaggatttgacaatt g" /listShort="S1286, ssrA, S1285" /listLong="yvaG" /label="upshifts" promotor_-10 complement(3102312..3102331) /Source="Nicolas_upshift_promotors" /id="U2644" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.701298701298701" /psig="0.997002997002997" /xcortree=1911 /SigmaFactorBS="aggcttctaaaggcatagTGCTTGATtcgaaaatcaggccTG TGCTATACTGTGTTCACGatcagatcacgacgccattcatttgaaggatttgacaatt g" /listShort="S1286, ssrA, S1285" /listLong="yvaG" /label="promotor_-10" promotor_-35 complement(3102346..3102353) /Source="Nicolas_upshift_promotors" /id="U2644" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.701298701298701" /psig="0.997002997002997" /xcortree=1911 /SigmaFactorBS="aggcttctaaaggcatagTGCTTGATtcgaaaatcaggccTG TGCTATACTGTGTTCACGatcagatcacgacgccattcatttgaaggatttgacaatt g" /listShort="S1286, ssrA, S1285" /listLong="yvaG" /label="promotor_-35" CDS complement(3102362..3102832) /gene="smpB" /locus_tag="BSU_33600" /old_locus_tag="BSU33600" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10947848, 11395451, 11918677, 12682299, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10947848, 11395451, 11918677, 12682299, 26735940; Product type f: factor" /codon_start=1 /transl_table=11 /product="tmRNA-binding protein" /protein_id="NP_391240.1" /db_xref="EnsemblGenomes-Gn:BSU33600" /db_xref="EnsemblGenomes-Tr:CAB15365" /db_xref="GOA:O32230" /db_xref="InterPro:IPR000037" /db_xref="InterPro:IPR020081" /db_xref="InterPro:IPR023620" /db_xref="SubtiList:BG14064" /db_xref="UniProtKB/Swiss-Prot:O32230" /translation="MPKGSGKVLSQNKKANHDYFIEETYETGIVLQGTEIKSIRAGRV NLKDSFAKIERGEVFLHNMHVSPYEQGNRYNHDPLRTRKLLMHRKEINKLIGLTKEKG YSLVPLKLYLKNGFAKVLLGLGKGKKNYDKREDLKRKDAKREIERAFRDSQKGF*" /label="smpB CDS" gene complement(3102362..3102832) /gene="smpB" /locus_tag="BSU_33600" /old_locus_tag="BSU33600" /label="smpB gene" promotor_no_box 3102659..3102759 /Source="Nicolas_upshift_promotors" /id="U2645" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.94005994005994" /psig="0.018981018981019" /xcortree=38 /SigmaFactorBS="cacttctccccgttcgattttggcgaaggaatccttaaggtt tacgcggccggcgcgaatcgatttgatttcggttccttgcagaacgatgcctgtttca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 3102719 /Source="Nicolas_upshifts" /id="U2645" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.94005994005994" /psig="0.018981018981019" /xcortree=38 /SigmaFactorBS="cacttctccccgttcgattttggcgaaggaatccttaaggtt tacgcggccggcgcgaatcgatttgatttcggttccttgcagaacgatgcctgtttca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 3102829 /Source="Nicolas_upshifts" /id="D1746" /incds=0 /nref=2 /ntot=105 /MaxReadThrough="0.62459" /MaxDrop="3.18501" /score="-9.3042809" /energy="-3.3" /TU="NA" /idTUdmin="U2647" /TUdmin="-1408" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3102877..3102896) /Source="Nicolas_upshift_promotors" /id="U2646" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.375624375624376" /psig="0.996003996003996" /xcortree=1853 /SigmaFactorBS="atttgctttctttcggaaacagcttttcATTGtagcggtacg tgacaTTTGGTAAAATAGAGCGTATcgcaaaaggtggacagtttttccttagagagag g" /listShort="smpB, S1286" /listLong="ssrA, S1285, yvaG" /label="promotor_-10" upshifts complement(3102883) /Source="Nicolas_upshifts" /id="U2646" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.375624375624376" /psig="0.996003996003996" /xcortree=1853 /SigmaFactorBS="atttgctttctttcggaaacagcttttcATTGtagcggtacg tgacaTTTGGTAAAATAGAGCGTATcgcaaaaggtggacagtttttccttagagagag g" /listShort="smpB, S1286" /listLong="ssrA, S1285, yvaG" /label="upshifts" S_feature complement(3102885..3102976) /Source="Nicolas_S_feature" /locus_tag="new_3451771_3451862_c" /HighExp="Etha, S8, Cold, S7, G135, G180, G150, H2O2, M9-stat, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigA" /TUshortPSig="0.999, 1" /TUlongSig="SigA" /TUlongPSig="0.753" /label="S1287" promotor_-35 complement(3102912..3102915) /Source="Nicolas_upshift_promotors" /id="U2646" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.375624375624376" /psig="0.996003996003996" /xcortree=1853 /SigmaFactorBS="atttgctttctttcggaaacagcttttcATTGtagcggtacg tgacaTTTGGTAAAATAGAGCGTATcgcaaaaggtggacagtttttccttagagagag g" /listShort="smpB, S1286" /listLong="ssrA, S1285, yvaG" /label="promotor_-35" CDS complement(3102977..3105316) /gene="rnr" /locus_tag="BSU_33610" /old_locus_tag="BSU33610" /EC_number="3.1.13.1" /function="16.3: Control" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12399495, 15805522, 15983136, 19215769, 22333191" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12399495, 15805522, 15983136, 19215769, 22333191; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease R" /protein_id="NP_391241.1" /db_xref="EnsemblGenomes-Gn:BSU33610" /db_xref="EnsemblGenomes-Tr:CAB15366" /db_xref="GOA:O32231" /db_xref="InterPro:IPR003029" /db_xref="InterPro:IPR004476" /db_xref="InterPro:IPR011129" /db_xref="InterPro:IPR011805" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR013223" /db_xref="InterPro:IPR022966" /db_xref="InterPro:IPR022967" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG14065" /db_xref="UniProtKB/Swiss-Prot:O32231" /translation="MEKEAFMEKLLSFMKEEAYKPLTVQELEEMLNITEAEEFKELVK ALVALEEKGLIVRTRSDRYGIPEKMNLIKGKISAHAKGFAFLLPEDTSLSDVFIPPNE LNTAMNGDIVMVRLNSQSSGSRQEGTVIRILERAIQRVVGTYTETRNFGFVIPDDKKI TSDIFIPKNGKNGAAEGHKVVVKLTSYPEGRMNAEGEVETILGHKNDPGIDILSVIHK HGLPGEFPADAMEQASSTPDTIDEKDLKDRRDLRDQVIVTIDGADAKDLDDAVTVTKL DDGSYKLGVHIADVSHYVTENSPIDKEALERGTSVYLVDRVIPMIPHRLSNGICSLNP KVDRLTLSCEMTINSQGQVTEHEIFQSVIKTTERMTYSDVNKILVDDDEELKQKYEPL VPMFKDMERLAQILRDKRMDRGAVDFDFKEAKVLVDDEGAVKDVVIRERSVAEKLIEE FMLVANETVAEHFHWMNVPFIYRIHEEPNAEKLQKFLEFVTTFGYVVKGTAGNIHPRA LQSILDAVRDRPEETVISTVMLRSMKQAKYDPQSLGHFGLSTEFYTHFTSPIRRYPDL IVHRLIRTYLINGKVDEATQEKWAERLPDIAEHTSSMERRAVDAERETDDLKKAEYML DKIGEEFDGMISSVTNFGMFVELPNTIEGLVHVSFMTDDYYRFDEQHFAMIGERTGNV FRIGDEITVKVVDVNKDERNIDFEIVGMKGTPRRPRELDSSRSRKRGKPARKRVQSTN TPVSPAPSEEKGEWFTKPKKKKKKRGFQNAPKQKRKKKK*" /label="rnr CDS" gene complement(3102977..3105316) /gene="rnr" /locus_tag="BSU_33610" /old_locus_tag="BSU33610" /label="rnr gene" promotor_-35 3104077..3104080 /Source="Nicolas_upshift_promotors" /id="U2647" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.988011988011988" /psig="0.000999000999001" /xcortree=49 /SigmaFactorBS="ctttgcttctttgaaatcaaagtcaacggcgcCGCGgtccat ccgcttatcGCGCagaatttgagccagacgctccatgtctttgaacatcggaacaaga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3104096..3104099 /Source="Nicolas_upshift_promotors" /id="U2647" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.988011988011988" /psig="0.000999000999001" /xcortree=49 /SigmaFactorBS="ctttgcttctttgaaatcaaagtcaacggcgcCGCGgtccat ccgcttatcGCGCagaatttgagccagacgctccatgtctttgaacatcggaacaaga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3104105 /Source="Nicolas_upshifts" /id="U2647" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.988011988011988" /psig="0.000999000999001" /xcortree=49 /SigmaFactorBS="ctttgcttctttgaaatcaaagtcaacggcgcCGCGgtccat ccgcttatcGCGCagaatttgagccagacgctccatgtctttgaacatcggaacaaga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3105335..3106075) /gene="estA" /locus_tag="BSU_33620" /old_locus_tag="BSU33620" /EC_number="3.1.1.1" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1369099, 17369301; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="carboxylesterase" /protein_id="NP_391242.2" /db_xref="EnsemblGenomes-Gn:BSU33620" /db_xref="EnsemblGenomes-Tr:CAB15367" /db_xref="GOA:O32232" /db_xref="InterPro:IPR012354" /db_xref="InterPro:IPR022742" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG14066" /db_xref="UniProtKB/Swiss-Prot:O32232" /translation="MKVVTPKPFTFKGGDKAVLLLHGFTGNTADVRMLGRYLNERGYT CHAPQYEGHGVPPEELVHTGPEDWWKNVMDGYEYLKSEGYESIAACGLSLGGVFSLKL GYTVPIKGIVPMCAPMHIKSEEVMYQGVLSYARNYKKFEGKSPEQIEEEMKEFEKTPM NTLKALQDLIADVRNNVDMIYSPTFVVQARHDHMINTESANIIYNEVETDDKQLKWYE ESGHVITLDKERDLVHQDVYEFLEKLDW*" /label="estA CDS" gene complement(3105335..3106075) /gene="estA" /locus_tag="BSU_33620" /old_locus_tag="BSU33620" /label="estA gene" promotor_-10 complement(3105731..3105749) /Source="Nicolas_upshift_promotors" /id="U2648" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=745 /SigmaFactorBS="actgtcgcttggcggggttttttcgctgaaattGGGTTACac tgtacccataaaGGGAATTGTCCCAATGTGCgcaccgatgcatattaagagtgaagag g" /listShort="rnr, S1287, smpB" /listLong="S1286, ssrA" /label="promotor_-10" upshifts complement(3105743) /Source="Nicolas_upshifts" /id="U2648" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=745 /SigmaFactorBS="actgtcgcttggcggggttttttcgctgaaattGGGTTACac tgtacccataaaGGGAATTGTCCCAATGTGCgcaccgatgcatattaagagtgaagag g" /listShort="rnr, S1287, smpB" /listLong="S1286, ssrA" /label="upshifts" promotor_-35 complement(3105764..3105770) /Source="Nicolas_upshift_promotors" /id="U2648" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=745 /SigmaFactorBS="actgtcgcttggcggggttttttcgctgaaattGGGTTACac tgtacccataaaGGGAATTGTCCCAATGTGCgcaccgatgcatattaagagtgaagag g" /listShort="rnr, S1287, smpB" /listLong="S1286, ssrA" /label="promotor_-35" misc_feature complement(3106103..3106121) /Source="Nicolas_upshift_promotors" /id="U2649" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.376623376623377" /psig="0.753246753246753" /xcortree=634 /SigmaFactorBS="gtcaggcctttttcacgtttctggatgatattcaaaacgttt ttttctgattaaacTGTGGAAAACTAAAATGATcgtgcagatagaaagggagacatga g" /listShort="yvaK, rnr" /listLong="S1287, smpB, S1286, ssrA" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3106117) /Source="Nicolas_upshifts" /id="U2649" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.376623376623377" /psig="0.753246753246753" /xcortree=634 /SigmaFactorBS="gtcaggcctttttcacgtttctggatgatattcaaaacgttt ttttctgattaaacTGTGGAAAACTAAAATGATcgtgcagatagaaagggagacatga g" /listShort="yvaK, rnr" /listLong="S1287, smpB, S1286, ssrA" /label="upshifts" downshifts complement(3106205) /Source="Nicolas_upshifts" /id="D1747" /incds=0 /nref=30 /ntot=212 /MaxReadThrough="6.16751" /MaxDrop="5.2246" /score="-4.14736839" /energy="-9.1" /TU="U2650" /idTUdmin="U2649" /TUdmin="-3234" /isTUend="FALSE" /label="downshifts" CDS complement(3106207..3106437) /gene="secG" /locus_tag="BSU_33630" /old_locus_tag="BSU33630" /function="16.2: Construct biomass (Anabolism)" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10074070, 10644701, 16243836" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10074070, 10644701, 16243836; Product type f: factor" /codon_start=1 /transl_table=11 /product="preprotein translocase subunit" /protein_id="NP_391243.1" /db_xref="EnsemblGenomes-Gn:BSU33630" /db_xref="EnsemblGenomes-Tr:CAB15368" /db_xref="GOA:O32233" /db_xref="InterPro:IPR004692" /db_xref="SubtiList:BG14067" /db_xref="UniProtKB/Swiss-Prot:O32233" /translation="MHAVLITLLVIVSIALIIVVLLQSSKSAGLSGAISGGAEQLFGK QKARGLDLILHRITVVLAVLFFVLTIALAYIL*" /label="secG CDS" gene complement(3106207..3106437) /gene="secG" /locus_tag="BSU_33630" /old_locus_tag="BSU33630" /label="secG gene" promotor_-10 complement(3106467..3106486) /Source="Nicolas_upshift_promotors" /id="U2650" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=2177 /SigmaFactorBS="accaagataaaacgtcttatccggccttttggcgtctgatac agCGTGacatgccaacccttTTCATGTAAAATAGAAGTAAtgtagccagtgagtctgg a" /listShort="secG, yvaK, rnr, S1287, smpB, S1286" /listLong="ssrA, S1285, yvaG" /label="promotor_-10" upshifts complement(3106488) /Source="Nicolas_upshifts" /id="U2650" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=2177 /SigmaFactorBS="accaagataaaacgtcttatccggccttttggcgtctgatac agCGTGacatgccaacccttTTCATGTAAAATAGAAGTAAtgtagccagtgagtctgg a" /listShort="secG, yvaK, rnr, S1287, smpB, S1286" /listLong="ssrA, S1285, yvaG" /label="upshifts" promotor_-35 complement(3106501..3106504) /Source="Nicolas_upshift_promotors" /id="U2650" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.903096903096903" /psig=1 /xcortree=2177 /SigmaFactorBS="accaagataaaacgtcttatccggccttttggcgtctgatac agCGTGacatgccaacccttTTCATGTAAAATAGAAGTAAtgtagccagtgagtctgg a" /listShort="secG, yvaK, rnr, S1287, smpB, S1286" /listLong="ssrA, S1285, yvaG" /label="promotor_-35" promotor_-35 3106526..3106532 /Source="Nicolas_upshift_promotors" /id="U2651" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=928 /SigmaFactorBS="aagggttggcatgtcacgctgtatcagacgccaaaaggcCGG ATAAgacgttttatcttGGTTACCCTATTcatatgaaaaggtcaaaggagaaaagcga t" /listShort="yvaM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3106546..3106557 /Source="Nicolas_upshift_promotors" /id="U2651" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=928 /SigmaFactorBS="aagggttggcatgtcacgctgtatcagacgccaaaaggcCGG ATAAgacgttttatcttGGTTACCCTATTcatatgaaaaggtcaaaggagaaaagcga t" /listShort="yvaM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3106547 /Source="Nicolas_upshifts" /id="U2651" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=928 /SigmaFactorBS="aagggttggcatgtcacgctgtatcagacgccaaaaggcCGG ATAAgacgttttatcttGGTTACCCTATTcatatgaaaaggtcaaaggagaaaagcga t" /listShort="yvaM" /GFF_Attribute="listLong" /label="upshifts" CDS 3106586..3107356 /gene="yvaM" /locus_tag="BSU_33640" /old_locus_tag="BSU33640" /EC_number="3.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_391244.1" /db_xref="EnsemblGenomes-Gn:BSU33640" /db_xref="EnsemblGenomes-Tr:CAB15369" /db_xref="GOA:O32234" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="SubtiList:BG14068" /db_xref="UniProtKB/Swiss-Prot:O32234" /translation="MPLISIDSRKHLFYEEYGQGIPIIFIHPPGMGRKVFYYQRLLSK HFRVIFPDLSGHGDSDHIDQPASISYYANEIAQFMDALHIDKAVLFGYSAGGLIAQHI GFTRPDKVSHLILSGAYPAVHNVIGQKLHKLGMYLLEKNPGLLMKILAGSHTKDRQLR SILTDHMKKADQAHWHQYYLDSLGYNCIEQLPRLEMPMLFMYGGLRDWTFTNAGYYRR SCRHAEFFRLEYQGHQLPTKQWKTCNELVTGFVLTHHS*" /label="yvaM CDS" gene 3106586..3107356 /gene="yvaM" /locus_tag="BSU_33640" /old_locus_tag="BSU33640" /label="yvaM gene" promotor_-35 3106608..3106616 /Source="Nicolas_upshift_promotors" /id="U2652" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=538 /SigmaFactorBS="cagcatagacaGCAGGAAACatcttttttaTGAAGAATATGG ACAGGGAatccctatcatttttatccacccgccgggcatgggacgaaaggttttttat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3106627..3106645 /Source="Nicolas_upshift_promotors" /id="U2652" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=538 /SigmaFactorBS="cagcatagacaGCAGGAAACatcttttttaTGAAGAATATGG ACAGGGAatccctatcatttttatccacccgccgggcatgggacgaaaggttttttat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3106657 /Source="Nicolas_upshifts" /id="U2652" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=538 /SigmaFactorBS="cagcatagacaGCAGGAAACatcttttttaTGAAGAATATGG ACAGGGAatccctatcatttttatccacccgccgggcatgggacgaaaggttttttat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3107396..3107629) /gene="yvzC" /locus_tag="BSU_33650" /old_locus_tag="BSU33650" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative phage-like transcriptional regulator" /protein_id="NP_391245.1" /db_xref="EnsemblGenomes-Gn:BSU33650" /db_xref="EnsemblGenomes-Tr:CAB15370" /db_xref="GOA:O32235" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010982" /db_xref="SubtiList:BG14159" /db_xref="UniProtKB/Swiss-Prot:O32235" /translation="MPVEKIQIRRDYVLQYMVNNDYSLNQLALEIGVSPATLSRVLNG ERRPGQLVIGKMLHYFNLKFEDLFYYDFVDKSQ*" /label="yvzC CDS" gene complement(3107396..3107629) /gene="yvzC" /locus_tag="BSU_33650" /old_locus_tag="BSU33650" /label="yvzC gene" promotor_-35 3107720..3107727 /Source="Nicolas_upshift_promotors" /id="U2653" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5994005994006" /psig="0.985014985014985" /xcortree=2531 /SigmaFactorBS="attacggcttatgttaacttttgtcaatacatttccagtcta cctATTCCCTTtagtcaataaaCATACTAAAATATGAGTAACagtgagggacggggtg a" /listShort="rghRA, rghRB, yvaP" /listLong="S1288, yvaQ" /label="promotor_-35" upshifts 3107735 /Source="Nicolas_upshifts" /id="U2653" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5994005994006" /psig="0.985014985014985" /xcortree=2531 /SigmaFactorBS="attacggcttatgttaacttttgtcaatacatttccagtcta cctATTCCCTTtagtcaataaaCATACTAAAATATGAGTAACagtgagggacggggtg a" /listShort="rghRA, rghRB, yvaP" /listLong="S1288, yvaQ" /label="upshifts" promotor_-10 3107739..3107758 /Source="Nicolas_upshift_promotors" /id="U2653" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5994005994006" /psig="0.985014985014985" /xcortree=2531 /SigmaFactorBS="attacggcttatgttaacttttgtcaatacatttccagtcta cctATTCCCTTtagtcaataaaCATACTAAAATATGAGTAACagtgagggacggggtg a" /listShort="rghRA, rghRB, yvaP" /listLong="S1288, yvaQ" /label="promotor_-10" CDS 3107781..3108188 /gene="rghRA" /locus_tag="BSU_33660" /old_locus_tag="BSU33660" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16553878, 17227471" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16553878, 17227471; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor" /protein_id="NP_391246.1" /db_xref="EnsemblGenomes-Gn:BSU33660" /db_xref="EnsemblGenomes-Tr:CAB15371" /db_xref="GOA:O32236" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR016759" /db_xref="SubtiList:BG14069" /db_xref="UniProtKB/Swiss-Prot:O32236" /translation="MESFGEQLRALREERKLTVNQLATYSGVSAAGISRIENGKRGVP KPATIKKLAEALKIPYEGLMYKAGYIEEVHEARAPYETKCKLLEKAEAYDLKNLALLE NEKWQYLNKEDLLMLDHYFSFISDEAKKRSADD*" /label="rghRA CDS" gene 3107781..3108188 /gene="rghRA" /locus_tag="BSU_33660" /old_locus_tag="BSU33660" /label="rghRA gene" CDS 3108218..3108637 /gene="rghRB" /locus_tag="BSU_33670" /old_locus_tag="BSU33670" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17227471; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative phage-like transcriptional repressor" /protein_id="NP_391247.1" /db_xref="EnsemblGenomes-Gn:BSU33670" /db_xref="EnsemblGenomes-Tr:CAB15372" /db_xref="GOA:O32237" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR016759" /db_xref="SubtiList:BG14070" /db_xref="UniProtKB/Swiss-Prot:O32237" /translation="MSPFGQQLRELRRARKLTVNQLAVYSGISSATISKIENGKRGTP KPATIKKLAAVLKVPYENLMAAAGHIQAFPEEIREASEGYQSVYEIYQTAVTRGAEHL PIFNSQKWEHLSKQDIENLSKYFDFLSSEAKKRASSS*" /label="rghRB CDS" gene 3108218..3108637 /gene="rghRB" /locus_tag="BSU_33670" /old_locus_tag="BSU33670" /label="rghRB gene" promotor_-35 3108675..3108682 /Source="Nicolas_upshift_promotors" /id="U2654" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.929070929070929" /psig=1 /xcortree=2041 /SigmaFactorBS="tgtttctctttctatattttatcaatcacgctTGCATGCCct ccctcgttattTGCGTTATAATAGTGACAGAcgaggtgaaaagtatgaaccaatcaga a" /listShort="yvaP, S1288, yvaQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3108696..3108715 /Source="Nicolas_upshift_promotors" /id="U2654" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.929070929070929" /psig=1 /xcortree=2041 /SigmaFactorBS="tgtttctctttctatattttatcaatcacgctTGCATGCCct ccctcgttattTGCGTTATAATAGTGACAGAcgaggtgaaaagtatgaaccaatcaga a" /listShort="yvaP, S1288, yvaQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3108703 /Source="Nicolas_upshifts" /id="U2654" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.929070929070929" /psig=1 /xcortree=2041 /SigmaFactorBS="tgtttctctttctatattttatcaatcacgctTGCATGCCct ccctcgttattTGCGTTATAATAGTGACAGAcgaggtgaaaagtatgaaccaatcaga a" /listShort="yvaP, S1288, yvaQ" /GFF_Attribute="listLong" /label="upshifts" CDS 3108729..3109055 /gene="catR" /locus_tag="BSU_33680" /old_locus_tag="BSU33680" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:20639328" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20639328; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of catechol dioxygenase" /protein_id="NP_391248.2" /db_xref="EnsemblGenomes-Gn:BSU33680" /db_xref="EnsemblGenomes-Tr:CAB15373" /db_xref="GOA:O32238" /db_xref="InterPro:IPR002577" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG14071" /db_xref="UniProtKB/Swiss-Prot:O32238" /translation="MNQSEMCPRFEKAVDILSKRWVALIVFQLLNGSQRFSEIEAALP NLSGRVLSERLKELELEGVVKRDVIPETPVRIEYSLTDKGKALAPILGEISKWATEWI DPSFLD*" /label="catR CDS" gene 3108729..3109055 /gene="catR" /locus_tag="BSU_33680" /old_locus_tag="BSU33680" /label="catR gene" S_feature 3109056..3109140 /Source="Nicolas_S_feature" /locus_tag="new_3457942_3458026" /HighExp="Cold, H2O2, Diami, LBGstat, LPhT, dia15, G180, Paraq, Etha, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.985" /label="S1288" promotor_-35 3109111..3109118 /Source="Nicolas_upshift_promotors" /id="U2655" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2826 /SigmaFactorBS="acgagaaaagaaccgttttttattttccaGGTGAAAAaaaga tatctcaGCCGATATATAGTACATCCacacattacgtttttaaaggagaccactatat g" /listShort="yvaQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3109131..3109149 /Source="Nicolas_upshift_promotors" /id="U2655" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2826 /SigmaFactorBS="acgagaaaagaaccgttttttattttccaGGTGAAAAaaaga tatctcaGCCGATATATAGTACATCCacacattacgtttttaaaggagaccactatat g" /listShort="yvaQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3109142 /Source="Nicolas_upshifts" /id="U2655" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2826 /SigmaFactorBS="acgagaaaagaaccgttttttattttccaGGTGAAAAaaaga tatctcaGCCGATATATAGTACATCCacacattacgtttttaaaggagaccactatat g" /listShort="yvaQ" /GFF_Attribute="listLong" /label="upshifts" CDS 3109180..3110880 /gene="yvaQ" /locus_tag="BSU_33690" /old_locus_tag="BSU33690" /function="16.3: Control" /function="16.12: Sense" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8188684, 11872722, 27899502; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative methyl-accepting transducer" /protein_id="NP_391249.1" /db_xref="EnsemblGenomes-Gn:BSU33690" /db_xref="EnsemblGenomes-Tr:CAB15374" /db_xref="GOA:O32239" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR004089" /db_xref="InterPro:IPR004090" /db_xref="InterPro:IPR024478" /db_xref="InterPro:IPR035440" /db_xref="SubtiList:BG14072" /db_xref="UniProtKB/Swiss-Prot:O32239" /translation="MRLTISRKFSLVFLTLILINLLVGGIGVLNMQHIIQKTDEINTK WIDGIKGITSINYVTEHLSSKEKDFLIYTDKSKMDTLDQEMNQIMEDINQKLDNYEKT ISTDKEQKLFEQLQTKVNTYMDIHAQIIESGRTNDMDKARGLLVQTEASFEDMKKTIT QLVDLNQEGSNTAVKETKAVYHKGLIYTALLVAASILISIFIWLYITRNIVKPIIRMK ESANHIAEGDLSNDMEALNSKDELGDLNEALQKMVGNLRDIVGYSKDISSRVLSSSQV LATATNETRSGSKHITETMNEMAEGSEQQAQDAVTIAESMNEFTESIDKAYNHGITIS DTSQNVLELAVSGNENMATSLQQMKTIHHIVEEAVHKVRSLEQHSQDINKLVQVINGI AEQTNLLSLNAAIEAARAGESGKGFAVVAEEVRKLADGVSDSVQDITRIVNGTQQEIH TVITYLESSFTEVEKGTENLTDTGQAMQHIKQSVTHVADSIKEVTDGLKQLTNQSITI NQSIENIASVSEESAAGIEETFSITEQSAHSMDQVLLNAEELEQLANELNEKMGQFTI *" /label="yvaQ CDS" gene 3109180..3110880 /gene="yvaQ" /locus_tag="BSU_33690" /old_locus_tag="BSU33690" /label="yvaQ gene" S_feature complement(3109896..3110889) /Source="Nicolas_S_feature" /locus_tag="new_3458782_3459775_c" /HighExp="S6, S5, S7, C30, S8, S4, S3, LoTm, BT, B36" /AntisenseName="yvaQ" /AntisenseCor="-0.38660715434937498" /AntisenseRegPval="-10.3" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1289" downshifts 3110858 /Source="Nicolas_upshifts" /id="D1748" /incds=0 /nref=30 /ntot=152 /MaxReadThrough="1.43789" /MaxDrop="3.86744" /score="26.1532813" /energy="-12.2" /TU="NA" /idTUdmin="U2655" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3110920..3111600) /gene="opuBD" /locus_tag="BSU_33700" /old_locus_tag="BSU33700" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9925583, 10216873, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9925583, 10216873, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="choline ABC transporter (permease)" /protein_id="NP_391250.1" /db_xref="EnsemblGenomes-Gn:BSU33700" /db_xref="EnsemblGenomes-Tr:CAB15375" /db_xref="GOA:P39775" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12636" /db_xref="UniProtKB/Swiss-Prot:P39775" /translation="MNVLEQLMTYYAQNGSYVMDEFGRHFLMSAYGVLFAAVVGVPAG ILIAHFRRLSAWVFAVTNVIQTIPALAMLAVLMLVMGLGANTVILSLFLYSLLPIIRN TYTGIISIEHAYLESGKAMGMTKFQVLRMVELPLALSVIMAGLRTALVIAIGITAIGT FVGAGGLGDMIVRGSNATNGTAIILAGAIPTAVMAVGADLLMAWLERALSPVKKKRTG AKHVQSAA*" /label="opuBD CDS" gene complement(3110920..3111600) /gene="opuBD" /locus_tag="BSU_33700" /old_locus_tag="BSU33700" /label="opuBD gene" downshifts complement(3110934) /Source="Nicolas_upshifts" /id="D1749" /incds=0 /nref=119 /ntot=171 /MaxReadThrough="3.12805" /MaxDrop="5.39624" /score="35.0134287" /energy="-12.2" /TU="NA" /idTUdmin="U2657" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 3111294..3111300 /Source="Nicolas_upshift_promotors" /id="U2656" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=210 /SigmaFactorBS="taggcatgttcaatactgataatgcctgtgtacgTGTTTCGa ataatcggcagcaGGGAATACAGAAATAATGAtagaatcacggtatttgcgccgagcc c" /listShort="S1290" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3111315..3111333 /Source="Nicolas_upshift_promotors" /id="U2656" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=210 /SigmaFactorBS="taggcatgttcaatactgataatgcctgtgtacgTGTTTCGa ataatcggcagcaGGGAATACAGAAATAATGAtagaatcacggtatttgcgccgagcc c" /listShort="S1290" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3111320..3114071 /Source="Nicolas_S_feature" /locus_tag="new_3460206_3462957" /HighExp="Sw, M9-stat, B60, Salt, LoTm, T0.30H, BC, Gly, B36, T1.0H" /AntisenseName="opuBC" /AntisenseCor="-0.13125567572652899" /AntisenseRegPval="-1.5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1290" upshifts 3111320 /Source="Nicolas_upshifts" /id="U2656" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=210 /SigmaFactorBS="taggcatgttcaatactgataatgcctgtgtacgTGTTTCGa ataatcggcagcaGGGAATACAGAAATAATGAtagaatcacggtatttgcgccgagcc c" /listShort="S1290" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3111617..3112537) /gene="opuBC" /locus_tag="BSU_33710" /old_locus_tag="BSU33710" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9925583, 10216873" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9925583, 10216873; Product type t: transporter" /codon_start=1 /transl_table=11 /product="choline ABC transporter (choline-binding lipoprotein)" /protein_id="NP_391251.1" /db_xref="EnsemblGenomes-Gn:BSU33710" /db_xref="EnsemblGenomes-Tr:CAB15376" /db_xref="GOA:Q45462" /db_xref="InterPro:IPR007210" /db_xref="PDB:3R6U" /db_xref="SubtiList:BG12635" /db_xref="UniProtKB/Swiss-Prot:Q45462" /translation="MKRKYLKLMIGLALAATLTLSGCSLPGLSAAADQTIKIGAQSMS ESEIIASMLGQLIEHHTDLKTTTIKNLGSNAVQQQALMNGEIDIAATRYTGDALTGTL RMEPEKDPDKALALTQREFKKRYDLKWYDSYGFDNTYAFTVSKELADQYHLETVSDVK KWAPQLKLGVDNYWMKLKGNGYQDFTKTYGMTFGGTYPMQIGLVYDAVKSGKMDIVLA YSTDGRIKSYGLKMLKDDKQFFPPYDCSPVVPEKVLKEHPELEGIIKKMLGKIDTATM QELNYEVDGNLKEPSVVAKEYLEKHRYFES*" /label="opuBC CDS" gene complement(3111617..3112537) /gene="opuBC" /locus_tag="BSU_33710" /old_locus_tag="BSU33710" /label="opuBC gene" CDS complement(3112549..3113202) /gene="opuBB" /locus_tag="BSU_33720" /old_locus_tag="BSU33720" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9925583, 10216873, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9925583, 10216873, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="choline ABC transporter (permease)" /protein_id="NP_391252.1" /db_xref="EnsemblGenomes-Gn:BSU33720" /db_xref="EnsemblGenomes-Tr:CAB15377" /db_xref="GOA:Q45461" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12634" /db_xref="UniProtKB/Swiss-Prot:Q45461" /translation="MHHIVQFLQTNGGELLYKTYEHITISLIAVILGVLVAVPLGVVL TRMKKGAGTIIGIVNIIQTLPSLAILAFFIPLLGVGKVPAIVALFFYSVLPILRNTYT GIRGVNKNLLESGKGIGMTPAEQVRLVELPLAAPVIMAGIRTSTIYLIGWATLASFIG GGGLGDYIFIGLNLYQPEYIIGGAVPVTILAIVIDYVLAVAERKLTPAGMQRLKELS* " /label="opuBB CDS" gene complement(3112549..3113202) /gene="opuBB" /locus_tag="BSU_33720" /old_locus_tag="BSU33720" /label="opuBB gene" CDS complement(3113219..3114364) /gene="opuBA" /locus_tag="BSU_33730" /old_locus_tag="BSU33730" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9925583, 10216873, 18321243, 21658392" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9925583, 10216873, 18321243, 21658392; Product type t: transporter" /codon_start=1 /transl_table=11 /product="choline ABC transporter (ATP-binding protein)" /protein_id="NP_391253.1" /db_xref="EnsemblGenomes-Gn:BSU33730" /db_xref="EnsemblGenomes-Tr:CAB15378" /db_xref="GOA:Q45460" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR005892" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12633" /db_xref="UniProtKB/Swiss-Prot:Q45460" /translation="MLTLENVSKTYKGGKKAVNNVNLKIAKGEFICFIGPSGCGKTTT MKMINRLIEPSAGKIFIDGENIMDQDPVELRRKIGYVIQQIGLFPHMTIQQNISLVPK LLKWPEQQRKERARELLKLVDMGPEYVDRYPHELSGGQQQRIGVLRALAAEPPLILMD EPFGALDPITRDSLQEEFKKLQKTLHKTIVFVTHDMDEAIKLADRIVILKAGEIVQVG TPDDILRNPADEFVEEFIGKERLIQSSSPDVERVDQIMNTQPVTITADKTLSEAIQLM RQERVDSLLVVNDERVLQGYVDVEIIDQCRKKANLVSEVLHEDIYTVLGGTLLRDTVR KILKRGVKYVPVVDEDRRLIGIVTRASLVDIVYDSLWGEEKQLAALS*" /label="opuBA CDS" gene complement(3113219..3114364) /gene="opuBA" /locus_tag="BSU_33730" /old_locus_tag="BSU33730" /label="opuBA gene" S_feature complement(3114365..3114432) /Source="Nicolas_S_feature" /locus_tag="new_3463251_3463318_c" /HighExp="T5.0H, T3.30H, T3.0H, T-5.40H, T4.0H, T-0.40H, T-1.40H, T2.30H, T-3.40H, T-2.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1291" upshifts complement(3114432) /Source="Nicolas_upshifts" /id="U2657" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.954045954045954" /psig=1 /xcortree=3047 /SigmaFactorBS="aataatatgaacaaattgtaaaCTTTttattttataaactTT ATTCTATAATGGGAAGCAttcaattgtctgaaaaattaaatttaaactgaacaaattg a" /listShort="S1291, opuBA, opuBB, opuBC, opuBD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3114433..3114452) /Source="Nicolas_upshift_promotors" /id="U2657" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.954045954045954" /psig=1 /xcortree=3047 /SigmaFactorBS="aataatatgaacaaattgtaaaCTTTttattttataaactTT ATTCTATAATGGGAAGCAttcaattgtctgaaaaattaaatttaaactgaacaaattg a" /listShort="S1291, opuBA, opuBB, opuBC, opuBD" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 3114463..3114467 /Source="Nicolas_upshift_promotors" /id="U2658" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.804195804195804" /psig="0.804195804195804" /xcortree=1202 /SigmaFactorBS="ttgaatgcttcccattatagaataaagtttataaaATAAAaa gtttacaatttgtTCATATTATTTATAAAGTAtgtgtaaacgctgatttacccgcatt g" /listShort="yvaV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(3114467..3114470) /Source="Nicolas_upshift_promotors" /id="U2657" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.954045954045954" /psig=1 /xcortree=3047 /SigmaFactorBS="aataatatgaacaaattgtaaaCTTTttattttataaactTT ATTCTATAATGGGAAGCAttcaattgtctgaaaaattaaatttaaactgaacaaattg a" /listShort="S1291, opuBA, opuBB, opuBC, opuBD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3114483..3114501 /Source="Nicolas_upshift_promotors" /id="U2658" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.804195804195804" /psig="0.804195804195804" /xcortree=1202 /SigmaFactorBS="ttgaatgcttcccattatagaataaagtttataaaATAAAaa gtttacaatttgtTCATATTATTTATAAAGTAtgtgtaaacgctgatttacccgcatt g" /listShort="yvaV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3114488 /Source="Nicolas_upshifts" /id="U2658" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.804195804195804" /psig="0.804195804195804" /xcortree=1202 /SigmaFactorBS="ttgaatgcttcccattatagaataaagtttataaaATAAAaa gtttacaatttgtTCATATTATTTATAAAGTAtgtgtaaacgctgatttacccgcatt g" /listShort="yvaV" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3114583..3114587 /Source="Nicolas_upshift_promotors" /id="U2659" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2455 /SigmaFactorBS="tattgctccaatttcctgccaaattctcttttgacagCATTT tcgccgtatcaaaaaTGTGGTATATTGACATCGGAattgttagctgaaaggatgaaac c" /listShort="yvaV" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3114603..3114622 /Source="Nicolas_upshift_promotors" /id="U2659" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2455 /SigmaFactorBS="tattgctccaatttcctgccaaattctcttttgacagCATTT tcgccgtatcaaaaaTGTGGTATATTGACATCGGAattgttagctgaaaggatgaaac c" /listShort="yvaV" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3114606 /Source="Nicolas_upshifts" /id="U2659" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2455 /SigmaFactorBS="tattgctccaatttcctgccaaattctcttttgacagCATTT tcgccgtatcaaaaaTGTGGTATATTGACATCGGAattgttagctgaaaggatgaaac c" /listShort="yvaV" /GFF_Attribute="listLong" /label="upshifts" CDS 3114648..3115181 /gene="yvaV" /locus_tag="BSU_33740" /old_locus_tag="BSU33740" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (controlling choline uptake)" /protein_id="NP_391254.2" /db_xref="EnsemblGenomes-Gn:BSU33740" /db_xref="EnsemblGenomes-Tr:CAB15379" /db_xref="GOA:C0SPB8" /db_xref="InterPro:IPR026282" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG14073" /db_xref="UniProtKB/Swiss-Prot:C0SPB8" /translation="MEKDPLTIIEQAEDHFIERIAENMHAFGMPSTVGRVLGIIYMNR KPMTLTELSEATGMSKTRMSQVVREMLDANIAEKVFEKGVRKDLYEVEQDYYQTFITL FSATWSKVVSKNKMMHKKLNRELLSVLDEELTPEAEEKVNELLKELKEWLDYYNWLSR LIEFFESEDIFKYVPKP*" /label="yvaV CDS" gene 3114648..3115181 /gene="yvaV" /locus_tag="BSU_33740" /old_locus_tag="BSU33740" /label="yvaV gene" S_feature complement(3114848..3115367) /Source="Nicolas_S_feature" /locus_tag="new_3463734_3464253_c" /HighExp="S8, Cold, C30, GM 25, GM 60, BC, T-4.40H, M/G, GM-0.1, MG 120" /AntisenseName="yvaV" /AntisenseCor="-7.6123637680436104E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.503, 1, 0.758" /TUlongSig="NA" /TUlongPSig="NA" /label="S1292" downshifts 3115170 /Source="Nicolas_upshifts" /id="D1750" /incds=0 /nref=51 /ntot=161 /MaxReadThrough="2.68472" /MaxDrop="4.69377" /score="-3.5823381" /energy="-8.6" /TU="NA" /idTUdmin="U2659" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 3115304..3115311 /Source="Nicolas_upshift_promotors" /id="U2660" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=2868 /SigmaFactorBS="taatgcataatttacattaatttattaattatccatttttTG TTGATTattctgactagctaTTATATAATCTTTTTGAAATgattatattagcttagag g" /listShort="S1293, sdpA, sdpB, spbC, S1297" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3115324..3115402 /Source="Nicolas_S_feature" /locus_tag="new_3464210_3464288" /HighExp="T-1.10H, T2.30H, T4.0H, T5.0H, T-2.40H, T2.0H, T-0.40H, M9-stat, T-5.40H, T1.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1293" upshifts 3115324 /Source="Nicolas_upshifts" /id="U2660" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=2868 /SigmaFactorBS="taatgcataatttacattaatttattaattatccatttttTG TTGATTattctgactagctaTTATATAATCTTTTTGAAATgattatattagcttagag g" /listShort="S1293, sdpA, sdpB, spbC, S1297" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3115326..3115345 /Source="Nicolas_upshift_promotors" /id="U2660" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=2868 /SigmaFactorBS="taatgcataatttacattaatttattaattatccatttttTG TTGATTattctgactagctaTTATATAATCTTTTTGAAATgattatattagcttagag g" /listShort="S1293, sdpA, sdpB, spbC, S1297" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(3115352..3115366) /Source="Nicolas_upshift_promotors" /id="U2661" /multdbtbs="-" /comp="M15" /sig="SigA" /pcomp="0.483516483516484" /psig="0.503496503496504" /xcortree=2951 /SigmaFactorBS="aaaataataggaaacatatagtcattacagtaataattccct tttttttgaTgtagattacCTCCTCTAAGCTAATataatcatttcaaaaagattatat a" /listShort="S1292" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3115367) /Source="Nicolas_upshifts" /id="U2661" /multdbtbs="-" /comp="M15" /sig="SigA" /pcomp="0.483516483516484" /psig="0.503496503496504" /xcortree=2951 /SigmaFactorBS="aaaataataggaaacatatagtcattacagtaataattccct tttttttgaTgtagattacCTCCTCTAAGCTAATataatcatttcaaaaagattatat a" /listShort="S1292" /GFF_Attribute="listLong" /label="upshifts" CDS 3115403..3115879 /gene="sdpA" /locus_tag="BSU_33750" /old_locus_tag="BSU33750" /function="16.11: Scavenge (Catabolism)" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:16469701, 17069462, 23687264" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16469701, 17069462, 23687264; Product type f: factor" /codon_start=1 /transl_table=11 /product="export step of killing factor SdpC" /protein_id="NP_391255.1" /db_xref="EnsemblGenomes-Gn:BSU33750" /db_xref="EnsemblGenomes-Tr:CAB15380" /db_xref="GOA:O34889" /db_xref="InterPro:IPR023902" /db_xref="SubtiList:BG14074" /db_xref="UniProtKB/Swiss-Prot:O34889" /translation="MTICFLLFSSYYFSNISPQNPLFKKNFLQQLSPQGFGFYSKSPT EENISFHTKENLKLPNALPNNFFGIKREGRVQAIELGKIVENIDPKNWKTCENNNSCT NLEKQIKPIKVIKNEDYIHLSKGEYLIYRQKPLSWYWIDFKQTTSFERKVLKIKIV*" /label="sdpA CDS" gene 3115403..3115879 /gene="sdpA" /locus_tag="BSU_33750" /old_locus_tag="BSU33750" /label="sdpA gene" promotor_-10 complement(3115428..3115447) /Source="Nicolas_upshift_promotors" /id="U2662" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.797202797202797" /psig=1 /xcortree=3097 /SigmaFactorBS="agacaattgttgcaaaaaattttttttgaacaGTGGATTCtg aggtgaaatATTGCTAAAGTAATAAGAAGaaaataataggaaacatatagtcattaca g" /listShort="S1292" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3115438) /Source="Nicolas_upshifts" /id="U2662" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.797202797202797" /psig=1 /xcortree=3097 /SigmaFactorBS="agacaattgttgcaaaaaattttttttgaacaGTGGATTCtg aggtgaaatATTGCTAAAGTAATAAGAAGaaaataataggaaacatatagtcattaca g" /listShort="S1292" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3115459..3115466) /Source="Nicolas_upshift_promotors" /id="U2662" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.797202797202797" /psig=1 /xcortree=3097 /SigmaFactorBS="agacaattgttgcaaaaaattttttttgaacaGTGGATTCtg aggtgaaatATTGCTAAAGTAATAAGAAGaaaataataggaaacatatagtcattaca g" /listShort="S1292" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3115876..3116847 /gene="sdpB" /locus_tag="BSU_33760" /old_locus_tag="BSU33760" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15743949, 15849754, 16469701, 16850406, 17069462, 23687264" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15743949, 15849754, 16469701, 16850406, 17069462, 23687264; Product type t : transporter" /codon_start=1 /transl_table=11 /product="export step of killing factor SdpC" /protein_id="NP_391256.1" /db_xref="EnsemblGenomes-Gn:BSU33760" /db_xref="EnsemblGenomes-Tr:CAB15381" /db_xref="GOA:O34616" /db_xref="InterPro:IPR007782" /db_xref="InterPro:IPR011020" /db_xref="InterPro:IPR023894" /db_xref="SubtiList:BG14075" /db_xref="UniProtKB/Swiss-Prot:O34616" /translation="MKILNSLEGYIDTYNPWKNTYALFRSLLGFSTLLVLLFNSTDIL FSYSANNVTCENVYIPTAFCFAKEYSINFEIIRYLMIFILTLVVIGWRPRFTGLFHWY ICYSIQTSALTIDGGEQIATVLSFLILPVTLLDSRRNHWNIKKNNNESFTKKTVLFYI MTIIKIQVFIIYLNAALERLKNKEWAEGTAIYYFFSDPVFGLPEYQLNLMNPLLESNF IVVITWLVTIFELFLAASIISNIRIKRIALVLGILFHIGIIFSIGIVSFGLIMISALI IYLHPVQQNITMNWCSPLFKYIYVKGKRNFKRIGGESVKFLTKLFHS*" /label="sdpB CDS" gene 3115876..3116847 /gene="sdpB" /locus_tag="BSU_33760" /old_locus_tag="BSU33760" /label="sdpB gene" promotor_no_box 3116684..3116784 /Source="Nicolas_upshift_promotors" /id="U2663" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.457542457542458" /psig="0.636363636363636" /xcortree=2869 /SigmaFactorBS="tcatgatatcagcattaattatatatctgcatcctgtacaac aaaatatcactatgaattggtgttctcctttatttaaatatatatatgtaaaaggaaa g" /listShort="spbC, S1297" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 3116744 /Source="Nicolas_upshifts" /id="U2663" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.457542457542458" /psig="0.636363636363636" /xcortree=2869 /SigmaFactorBS="tcatgatatcagcattaattatatatctgcatcctgtacaac aaaatatcactatgaattggtgttctcctttatttaaatatatatatgtaaaaggaaa g" /listShort="spbC, S1297" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3116756..3116773) /Source="Nicolas_upshift_promotors" /id="U2664" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.578421578421578" /psig="0.758241758241758" /xcortree=423 /SigmaFactorBS="aacaattttgtaagaaacttgactgattcacctcctattctt ttgAAAtttctctttccttttaCATATATATATTTAAATAaaggagaacaccaattca t" /listShort="S1292" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3116777) /Source="Nicolas_upshifts" /id="U2664" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.578421578421578" /psig="0.758241758241758" /xcortree=423 /SigmaFactorBS="aacaattttgtaagaaacttgactgattcacctcctattctt ttgAAAtttctctttccttttaCATATATATATTTAAATAaaggagaacaccaattca t" /listShort="S1292" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3116779..3117181) /Source="Nicolas_S_feature" /locus_tag="new_3465665_3466067_c" /HighExp="Gly, Lbstat, BT, S8, T1.30H, C30, M9-stat, C90, Sw, HiTm" /AntisenseName="spbC" /AntisenseCor="-0.16053929530879699" /AntisenseRegPval="-2.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1294" promotor_-35 complement(3116790..3116792) /Source="Nicolas_upshift_promotors" /id="U2664" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.578421578421578" /psig="0.758241758241758" /xcortree=423 /SigmaFactorBS="aacaattttgtaagaaacttgactgattcacctcctattctt ttgAAAtttctctttccttttaCATATATATATTTAAATAaaggagaacaccaattca t" /listShort="S1292" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3116808) /Source="Nicolas_upshifts" /id="D1751" /incds=0 /nref=1 /ntot=33 /MaxReadThrough="3.26001" /MaxDrop="4.09728" /score="-7.06061287" /energy="-10.3" /TU="NA" /idTUdmin="U2665" /TUdmin=286 /isTUend="FALSE" /label="downshifts" CDS 3116890..3117501 /gene="spbC" /locus_tag="BSU_33770" /old_locus_tag="BSU33770" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /function="16.4: Excrete" /experiment="publication(s) with functional evidences, PMID:15743949, 16469701, 17069462, 23687264" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15743949, 16469701, 17069462, 23687264; Product type f: factor" /codon_start=1 /transl_table=11 /product="precursor of killing factor SdpC" /protein_id="NP_391257.1" /db_xref="EnsemblGenomes-Gn:BSU33770" /db_xref="EnsemblGenomes-Tr:CAB15382" /db_xref="GOA:O34344" /db_xref="InterPro:IPR023888" /db_xref="SubtiList:BG14076" /db_xref="UniProtKB/Swiss-Prot:O34344" /translation="MKSKLLRLLIVSMVTILVFSLVGLSKESSTSAKENHTFSGEDYF RGLLFGQGEVGKLISNDLDPKLVKEANSTEGKKLVNDVVKFIKKDQPQYMDELKQSID SKDPKKLIENMTKADQLIQKYAKKNENVKYSSNKVTPSCGLYAVCVAAGYLYVVGVNA VALQTAAAVTTAVWKYVAKYSSSASNNSDLEAAAAKTLKLIHQ*" /label="spbC CDS" gene 3116890..3117501 /gene="spbC" /locus_tag="BSU_33770" /old_locus_tag="BSU33770" /label="spbC gene" S_feature complement(3117183..3117269) /Source="Nicolas_S_feature" /locus_tag="new_3466069_3466155_c" /HighExp="T1.30H, Gly, T2.0H, BT, S8, C30, Lbstat, C90, T1.0H, M9-stat" /AntisenseName="spbC" /AntisenseCor="-5.4790207146846799E-2" /AntisenseRegPval="-0.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1295" downshifts complement(3117226) /Source="Nicolas_upshifts" /id="D1752" /incds=1 /nref=1 /ntot=8 /MaxReadThrough="4.62458" /MaxDrop="2.00358" /score="8.72167152" /energy="-11.6" /TU="U2665" /idTUdmin="U2665" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" S_feature complement(3117271..3117456) /Source="Nicolas_S_feature" /locus_tag="new_3466157_3466342_c" /HighExp="T1.30H, T2.0H, M9-stat, T1.0H, B60, T2.30H, T5.0H, B36, T3.30H, T0.30H" /AntisenseName="spbC" /AntisenseCor="-4.2394313806342503E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.999" /label="S1296" downshifts complement(3117314) /Source="Nicolas_upshifts" /id="D1753" /incds=1 /nref=1 /ntot=14 /MaxReadThrough="4.27088" /MaxDrop="2.27366" /score="8.72167152" /energy="-11.6" /TU="U2665" /idTUdmin="U2665" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" downshifts 3117481 /Source="Nicolas_upshifts" /id="D1754" /incds=0 /nref=207 /ntot=252 /MaxReadThrough="4.65014" /MaxDrop="7.52715" /score="19.8036228" /energy="-20" /TU="U2660,U2663" /idTUdmin="U2660" /TUdmin="-1099" /isTUend="FALSE" /label="downshifts" downshifts complement(3117501) /Source="Nicolas_upshifts" /id="D1755" /incds=0 /nref=14 /ntot=94 /MaxReadThrough="6.14809" /MaxDrop="5.58575" /score="8.72167152" /energy="-11.6" /TU="U2665" /idTUdmin="U2667" /TUdmin=33 /isTUend="FALSE" /label="downshifts" S_feature 3117526..3118664 /Source="Nicolas_S_feature" /locus_tag="new_3466412_3467550" /HighExp="Pyr, S8, nit, C30, GM 150, M9-stat, S7, S2, G/S, S1" /AntisenseName="sdpI" /AntisenseCor="-7.9710115369408502E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.636, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1297" CDS complement(3117548..3118171) /gene="sdpI" /locus_tag="BSU_33780" /old_locus_tag="BSU33780" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12817086, 15849754, 16850406, 20563570, 23687264" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12817086, 15849754, 16850406, 20563570, 23687264; Product type r: regulator" /codon_start=1 /transl_table=11 /product="integral membrane immunity regulator of autophagy" /protein_id="NP_391258.1" /db_xref="EnsemblGenomes-Gn:BSU33780" /db_xref="EnsemblGenomes-Tr:CAB15383" /db_xref="GOA:O32241" /db_xref="InterPro:IPR012867" /db_xref="InterPro:IPR025962" /db_xref="InterPro:IPR026272" /db_xref="SubtiList:BG14077" /db_xref="UniProtKB/Swiss-Prot:O32241" /translation="MKKNIISIIIVCLSFLTSIILYQYLPEEIPIQWSGNKPAAIVSK PLTIFIIPVVMLIYYLTFYMLTIKSTQKNKALLFLASNNMLILLYILQLSTLLISLGY EVNIDLIIGLGVGIFLIIGGNSMQLAEQNHLIGLRTPWTLKDETVWKLGNRFASKVLV VCGFIIAVLSFFTGEYIILIMIVLVLLALVISTLASYHYYKKLNGSR*" /label="sdpI CDS" gene complement(3117548..3118171) /gene="sdpI" /locus_tag="BSU_33780" /old_locus_tag="BSU33780" /label="sdpI gene" downshifts complement(3117556) /Source="Nicolas_upshifts" /id="D1756" /incds=0 /nref=1 /ntot=95 /MaxReadThrough="6.43517" /MaxDrop="3.3455" /score="8.72167152" /energy="-11.6" /TU="U2665,U2667" /idTUdmin="U2667" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(3118168..3118440) /gene="sdpR" /locus_tag="BSU_33790" /old_locus_tag="BSU33790" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12817086, 17069462, 23687264" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12817086, 17069462, 23687264; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of SdpC synthesis operon (ArsR family)" /protein_id="NP_391259.1" /db_xref="EnsemblGenomes-Gn:BSU33790" /db_xref="EnsemblGenomes-Tr:CAB15384" /db_xref="GOA:O32242" /db_xref="InterPro:IPR001845" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG14078" /db_xref="UniProtKB/Swiss-Prot:O32242" /translation="MNNVFKAISDPTRRKILDLLKGGDMTAGDIAEHFNISKPSISHH LNILKQAEVISDHRKGQFIYYSLNTTVLQDSINWMLNFINKGDNDL*" /label="sdpR CDS" gene complement(3118168..3118440) /gene="sdpR" /locus_tag="BSU_33790" /old_locus_tag="BSU33790" /label="sdpR gene" promotor_-10 complement(3118496..3118515) /Source="Nicolas_upshift_promotors" /id="U2665" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.372627372627373" /psig=1 /xcortree=405 /SigmaFactorBS="tacaaaaatcagatattataaccaatttgaggGTTGTTTtta aaaaaattCAAGTTATAATGAAAATAATacatttatacaaatatctaaatgtctaaat g" /listShort="sdpR, sdpI, S1296, S1295, S1294" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3118505) /Source="Nicolas_upshifts" /id="U2665" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.372627372627373" /psig=1 /xcortree=405 /SigmaFactorBS="tacaaaaatcagatattataaccaatttgaggGTTGTTTtta aaaaaattCAAGTTATAATGAAAATAATacatttatacaaatatctaaatgtctaaat g" /listShort="sdpR, sdpI, S1296, S1295, S1294" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3118507..3118655) /Source="Nicolas_S_feature" /locus_tag="new_3467393_3467541_c" /HighExp="Salt, B36, Gly, B60, LoTm, S8, GM 5, MG 25, Cold, Mal" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1298" promotor_-35 complement(3118527..3118533) /Source="Nicolas_upshift_promotors" /id="U2665" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.372627372627373" /psig=1 /xcortree=405 /SigmaFactorBS="tacaaaaatcagatattataaccaatttgaggGTTGTTTtta aaaaaattCAAGTTATAATGAAAATAATacatttatacaaatatctaaatgtctaaat g" /listShort="sdpR, sdpI, S1296, S1295, S1294" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3118660..3119349) /gene="opuCD" /locus_tag="BSU_33800" /old_locus_tag="BSU33800" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9925583, 10216873, 15849754, 16850406, 28256787" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9925583, 10216873, 15849754, 16850406, 28256787; Product type t : transporter" /codon_start=1 /transl_table=11 /product="glycine betaine/carnitine/choline/choline sulfate ABC transporter (promiscuous permease)" /protein_id="NP_391260.1" /db_xref="EnsemblGenomes-Gn:BSU33800" /db_xref="EnsemblGenomes-Tr:CAB15385" /db_xref="GOA:O34742" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12640" /db_xref="UniProtKB/Swiss-Prot:O34742" /translation="MEVLQQLGTYYSQNGGYVLQEFYRHFLMSVYGVLFAAIVGIPLG ILIARYRRLSGWVFAVTNVIQTIPALAMLAVLMLVMGLGANTVILSLFLYSLLPIIRN TYTGIISIEHAYLESGKAMGMTKFQVLRMVELPLALSVIMAGLRTALVIAIGITAIGT FVGAGGLGDIIVRGSNATNGTAIILAGAIPTALMAVIADLVMGWLERALSPIKKKKGN FIIADRKTTSI*" /label="opuCD CDS" gene complement(3118660..3119349) /gene="opuCD" /locus_tag="BSU_33800" /old_locus_tag="BSU33800" /label="opuCD gene" downshifts complement(3118700) /Source="Nicolas_upshifts" /id="D1757" /incds=0 /nref=95 /ntot=199 /MaxReadThrough="5.55394" /MaxDrop="6.7177" /score="8.72167152" /energy="-11.6" /TU="U2667" /idTUdmin="U2667" /TUdmin="-1166" /isTUend="FALSE" /label="downshifts" promotor_-35 3119292..3119300 /Source="Nicolas_upshift_promotors" /id="U2666" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.763236763236763" /psig="0.763236763236763" /xcortree=767 /SigmaFactorBS="tcagaaaatggcggtaaaattcctGCAGCACGTaaccgccgt tttgCGAATAGTATGTGCCAAGCTgctgtagtacttccatatgatccacctcttttct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3119314..3119333 /Source="Nicolas_upshift_promotors" /id="U2666" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.763236763236763" /psig="0.763236763236763" /xcortree=767 /SigmaFactorBS="tcagaaaatggcggtaaaattcctGCAGCACGTaaccgccgt tttgCGAATAGTATGTGCCAAGCTgctgtagtacttccatatgatccacctcttttct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3119328 /Source="Nicolas_upshifts" /id="U2666" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.763236763236763" /psig="0.763236763236763" /xcortree=767 /SigmaFactorBS="tcagaaaatggcggtaaaattcctGCAGCACGTaaccgccgt tttgCGAATAGTATGTGCCAAGCTgctgtagtacttccatatgatccacctcttttct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3119367..3120278) /gene="opuCC" /locus_tag="BSU_33810" /old_locus_tag="BSU33810" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9925583, 10216873, 28256787" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9925583, 10216873, 28256787; Product type t: transporter" /codon_start=1 /transl_table=11 /product="glycine betaine/carnitine/choline/choline sulfate ABC transporter (osmoprotectant-binding lipoprotein)" /protein_id="NP_391261.1" /db_xref="EnsemblGenomes-Gn:BSU33810" /db_xref="EnsemblGenomes-Tr:CAB15386" /db_xref="GOA:O32243" /db_xref="InterPro:IPR007210" /db_xref="PDB:3PPN" /db_xref="PDB:3PPO" /db_xref="PDB:3PPP" /db_xref="PDB:3PPQ" /db_xref="PDB:3PPR" /db_xref="SubtiList:BG12639" /db_xref="UniProtKB/Swiss-Prot:O32243" /translation="MTKIKWLGAFALVFVMLLGGCSLPGLGGASDDTIKIGAQSMTES EIVANMIAQLIEHDTDLNTALVKNLGSNYVQHQAMLGGDIDISATRYSGTDLTSTLGK EAEKDPKKALNIVQNEFQKRFSYKWFDSYGFDNTYAFTVTKKFAEKEHINTVSDLKKN ASQYKLGVDNAWLKRKGDGYKGFVSTYGFEFGTTYPMQIGLVYDAVKNGKMDAVLAYS TDGRIKAYDLKILKDDKRFFPPYDCSPVIPEKVLKEHPELEGVINKLIGQIDTETMQE LNYEVDGKLKEPSVVAKEFLEKHHYFD*" /label="opuCC CDS" gene complement(3119367..3120278) /gene="opuCC" /locus_tag="BSU_33810" /old_locus_tag="BSU33810" /label="opuCC gene" CDS complement(3120298..3120951) /gene="opuCB" /locus_tag="BSU_33820" /old_locus_tag="BSU33820" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9925583, 10216873, 15849754, 16850406, 28256787" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9925583, 10216873, 15849754, 16850406, 28256787; Product type t : transporter" /codon_start=1 /transl_table=11 /product="glycine betaine/carnitine/choline/choline sulfate ABC transporter (promiscuous permease)" /protein_id="NP_391262.1" /db_xref="EnsemblGenomes-Gn:BSU33820" /db_xref="EnsemblGenomes-Tr:CAB15387" /db_xref="GOA:O34878" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12638" /db_xref="UniProtKB/Swiss-Prot:O34878" /translation="MNQMMTFLQTNGGELLYKTGEHLYISLIAVVLGIIVAVPLGVAL TRMKKGAGAVIGFVNIVQTLPSLAILAFFIPLLGVGKVPAIVALFFYSVLPILRNTYT GIKGVNKNLLESGKGIGMTGWEQIRLVEIPLAIPIIMAGIRTSTIYLIGWATLASFIG GGGLGDYIFIGLNLYQPEYIIGGAVPVTILAIIIDYVLAVTERKVTPKGLQGMKEVS* " /label="opuCB CDS" gene complement(3120298..3120951) /gene="opuCB" /locus_tag="BSU_33820" /old_locus_tag="BSU33820" /label="opuCB gene" CDS complement(3120974..3122116) /gene="opuCA" /locus_tag="BSU_33830" /old_locus_tag="BSU33830" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10216873, 9925583, 21658392, 27378384, 27683249" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10216873, 9925583, 21658392, 27378384, 27683249; Product type t : transporter" /codon_start=1 /transl_table=11 /product="glycine betaine/carnitine/choline/choline sulfate ABC transporter (ATP-binding protein)" /protein_id="NP_391263.1" /db_xref="EnsemblGenomes-Gn:BSU33830" /db_xref="EnsemblGenomes-Tr:CAB15388" /db_xref="GOA:O34992" /db_xref="InterPro:IPR000644" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR005892" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12637" /db_xref="UniProtKB/Swiss-Prot:O34992" /translation="MLKLEQVSKVYKGGKKAVNSIDLDIAKGEFICFIGPSGCGKTTT MKMINRLIEPSSGRIFIDGENIMEQDPVELRRKIGYVIQQIGLFPHMTIQQNISLVPK LLKWPEEKRKERARELLKLVDMGPEYLDRYPHELSGGQQQRIGVLRALAAEPPLILMD EPFGALDPITRDSLQEEFKKLQRTLNKTIVFVTHDMDEAIKLADRIVILKAGEIVQVG TPDEILRNPANEFVEEFIGKERLIQSRPDIERVEQMMNRTPVTVSADKTLSQAIQLMR EKRVDSLLVVDRQNVLKGYVDVEMIDQNRKKASIVGDVYRSDIYTVQKGALLRDTVRK ILKQGIKYVPVVDEQNHLAGIVTRASLVDIVYDSIWGDEENQLMTI*" /label="opuCA CDS" gene complement(3120974..3122116) /gene="opuCA" /locus_tag="BSU_33830" /old_locus_tag="BSU33830" /label="opuCA gene" promotor_-10 complement(3122160..3122179) /Source="Nicolas_upshift_promotors" /id="U2667" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.937062937062937" /psig="0.999000999001" /xcortree=3049 /SigmaFactorBS="taatctataaataacatataatttcaacacattgtaaaCTTT ttattttacaaagtTCAAACTATAATAAGGATTAtacttttcagaaaatttaaaggaa a" /listShort="opuCA, opuCB, opuCC, opuCD, S1298, sdpR, sdpI" /listLong="S1296" /label="promotor_-10" upshifts complement(3122175) /Source="Nicolas_upshifts" /id="U2667" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.937062937062937" /psig="0.999000999001" /xcortree=3049 /SigmaFactorBS="taatctataaataacatataatttcaacacattgtaaaCTTT ttattttacaaagtTCAAACTATAATAAGGATTAtacttttcagaaaatttaaaggaa a" /listShort="opuCA, opuCB, opuCC, opuCD, S1298, sdpR, sdpI" /listLong="S1296" /label="upshifts" promotor_-35 complement(3122194..3122197) /Source="Nicolas_upshift_promotors" /id="U2667" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.937062937062937" /psig="0.999000999001" /xcortree=3049 /SigmaFactorBS="taatctataaataacatataatttcaacacattgtaaaCTTT ttattttacaaagtTCAAACTATAATAAGGATTAtacttttcagaaaatttaaaggaa a" /listShort="opuCA, opuCB, opuCC, opuCD, S1298, sdpR, sdpI" /listLong="S1296" /label="promotor_-35" promotor_-35 3122313..3122320 /Source="Nicolas_upshift_promotors" /id="U2668" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.697302697302697" /psig="0.993006993006993" /xcortree=3046 /SigmaFactorBS="atacctcccacttcctctgcattcagctaTTTTCAACaccag gaagaaaTATGATATATTGACACCATCaattgccatttgaagggatgatcagctgtga a" /listShort="yvbF, S1299, yvbH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3122333..3122352 /Source="Nicolas_upshift_promotors" /id="U2668" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.697302697302697" /psig="0.993006993006993" /xcortree=3046 /SigmaFactorBS="atacctcccacttcctctgcattcagctaTTTTCAACaccag gaagaaaTATGATATATTGACACCATCaattgccatttgaagggatgatcagctgtga a" /listShort="yvbF, S1299, yvbH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3122344 /Source="Nicolas_upshifts" /id="U2668" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.697302697302697" /psig="0.993006993006993" /xcortree=3046 /SigmaFactorBS="atacctcccacttcctctgcattcagctaTTTTCAACaccag gaagaaaTATGATATATTGACACCATCaattgccatttgaagggatgatcagctgtga a" /listShort="yvbF, S1299, yvbH" /GFF_Attribute="listLong" /label="upshifts" CDS 3122380..3122937 /gene="opcR" /locus_tag="BSU_33840" /old_locus_tag="BSU33840" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:23960087" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23960087; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative transcriptional regulator of choline uptake systems" /protein_id="NP_391264.1" /db_xref="EnsemblGenomes-Gn:BSU33840" /db_xref="EnsemblGenomes-Tr:CAB15389" /db_xref="GOA:O34709" /db_xref="InterPro:IPR026282" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG14079" /db_xref="UniProtKB/Swiss-Prot:O34709" /translation="MKKTALDIIEHAEEHLIEKIAENMHTFGMPSTVGRVLGIIYMNR KPMTLSELSEATGMSKTRMSQVVREMIDANIAEKVFEKGVRKDLYDVEQDYYQTFISL FAANWTKVVSKNKVLYKKLNRELSDLLQRDGLTPEAEEKVNQLLNELKEWLHYYDWLS RLIEFFESEEVFRYVPKTKECSSLK*" /label="opcR CDS" gene 3122380..3122937 /gene="opcR" /locus_tag="BSU_33840" /old_locus_tag="BSU33840" /label="opcR gene" S_feature 3122938..3123702 /Source="Nicolas_S_feature" /locus_tag="new_3471824_3472588" /HighExp="HiOs, GM 5, GM 10, Salt, MG 15, MG 10, MG 25, T0.0H, T-2.40H, GM 45" /AntisenseName="yvbG" /AntisenseCor="-0.14921239095219299" /AntisenseRegPval="-1.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1299" CDS complement(3122955..3123590) /gene="yvbG" /locus_tag="BSU_33850" /old_locus_tag="BSU33850" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_391265.1" /db_xref="EnsemblGenomes-Gn:BSU33850" /db_xref="EnsemblGenomes-Tr:CAB15390" /db_xref="GOA:O32244" /db_xref="InterPro:IPR002771" /db_xref="SubtiList:BG14080" /db_xref="UniProtKB/Swiss-Prot:O32244" /translation="MMFSFIVHVFISLFAVSNPIGNVPIFLTLTEGYTAAERKAIARK AAILSFFILAAFLVFGHLIFKLFDINIHALRVAGGIFIFGIAYNLLNAKESHVQSLHH DEHKESKEKADISVTPLSIPIIAGPGTIATVMSLSAGHSGIGHYAAVMIGIAAVIALT FLFFHYSAFISSKLGKTEMNVITRLMGLILAVVAVGMIGAGLKGMFPVLTS*" /label="yvbG CDS" gene complement(3122955..3123590) /gene="yvbG" /locus_tag="BSU_33850" /old_locus_tag="BSU33850" /label="yvbG gene" downshifts complement(3122968) /Source="Nicolas_upshifts" /id="D1758" /incds=0 /nref=21 /ntot=50 /MaxReadThrough="2.02169" /MaxDrop="4.45088" /score="10.9231366" /energy="-16.4" /TU="NA" /idTUdmin="U2669" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3123631..3123649) /Source="Nicolas_upshift_promotors" /id="U2669" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=181 /SigmaFactorBS="atggcgcgtttctgacaggctataaaGGTTTACcgggaaatc gcctccGGGTAAAAGGGTGGAGAATcattctatttcctgtgcagagactatcaacaag g" /listShort="yvbG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3123637) /Source="Nicolas_upshifts" /id="U2669" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=181 /SigmaFactorBS="atggcgcgtttctgacaggctataaaGGTTTACcgggaaatc gcctccGGGTAAAAGGGTGGAGAATcattctatttcctgtgcagagactatcaacaag g" /listShort="yvbG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3123665..3123671) /Source="Nicolas_upshift_promotors" /id="U2669" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=181 /SigmaFactorBS="atggcgcgtttctgacaggctataaaGGTTTACcgggaaatc gcctccGGGTAAAAGGGTGGAGAATcattctatttcctgtgcagagactatcaacaag g" /listShort="yvbG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3123676..3123683 /Source="Nicolas_upshift_promotors" /id="U2670" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2261 /SigmaFactorBS="ttacccggaggcgatttcccggtaaacctttaTAGCCTGTca gaaacgcgcCATGCTACAATGAAGTGACAaattgaataggaaggacgtatacagatgt t" /listShort="yvbH, yvbI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3123695..3123714 /Source="Nicolas_upshift_promotors" /id="U2670" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2261 /SigmaFactorBS="ttacccggaggcgatttcccggtaaacctttaTAGCCTGTca gaaacgcgcCATGCTACAATGAAGTGACAaattgaataggaaggacgtatacagatgt t" /listShort="yvbH, yvbI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3123704 /Source="Nicolas_upshifts" /id="U2670" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.97902097902098" /psig=1 /xcortree=2261 /SigmaFactorBS="ttacccggaggcgatttcccggtaaacctttaTAGCCTGTca gaaacgcgcCATGCTACAATGAAGTGACAaattgaataggaaggacgtatacagatgt t" /listShort="yvbH, yvbI" /GFF_Attribute="listLong" /label="upshifts" CDS 3123740..3124354 /gene="yvbH" /locus_tag="BSU_33860" /old_locus_tag="BSU33860" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391266.1" /db_xref="EnsemblGenomes-Gn:BSU33860" /db_xref="EnsemblGenomes-Tr:CAB15391" /db_xref="InterPro:IPR011993" /db_xref="InterPro:IPR012544" /db_xref="InterPro:IPR021722" /db_xref="InterPro:IPR037063" /db_xref="SubtiList:BG14081" /db_xref="UniProtKB/Swiss-Prot:O32245" /translation="MFKKIAADALGLSDIGKIIEPQDYDKTDADDYVMHEDNEKIYFL IKTKADEYCFTNLALIHVDGERATSSKRTLKRYPYSQYKISDVFLETAGKVDLDVEIK FKLGGEQFDIDVHKDQIEKLKDLYKALLRIAETTYENDILINQAEQSLDKAVTILHHT RPEHVNIETQYKELTEFGFTWLTSVRSQYHIKDFGDVFEKYINN*" /label="yvbH CDS" gene 3123740..3124354 /gene="yvbH" /locus_tag="BSU_33860" /old_locus_tag="BSU33860" /label="yvbH gene" downshifts 3124340 /Source="Nicolas_upshifts" /id="D1759" /incds=0 /nref=110 /ntot=197 /MaxReadThrough="2.66824" /MaxDrop="5.86088" /score="-4.16829989" /energy="-7.9" /TU="U2670" /idTUdmin="U2668" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" promotor_-35 3124408..3124411 /Source="Nicolas_upshift_promotors" /id="U2671" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.623376623376623" /psig=1 /xcortree=2318 /SigmaFactorBS="ctatcgtgctcgtgtctttttttgtatgaatattGATTactt tacaacttttTTCTTTTATAATAAAACTATtagtctattttccctatattacagataa a" /listShort="yvbI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3124426..3124445 /Source="Nicolas_upshift_promotors" /id="U2671" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.623376623376623" /psig=1 /xcortree=2318 /SigmaFactorBS="ctatcgtgctcgtgtctttttttgtatgaatattGATTactt tacaacttttTTCTTTTATAATAAAACTATtagtctattttccctatattacagataa a" /listShort="yvbI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3124434 /Source="Nicolas_upshifts" /id="U2671" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.623376623376623" /psig=1 /xcortree=2318 /SigmaFactorBS="ctatcgtgctcgtgtctttttttgtatgaatattGATTactt tacaacttttTTCTTTTATAATAAAACTATtagtctattttccctatattacagataa a" /listShort="yvbI" /GFF_Attribute="listLong" /label="upshifts" CDS 3124486..3125184 /gene="yvbI" /locus_tag="BSU_33870" /old_locus_tag="BSU33870" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15849754, 16850406" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391267.1" /db_xref="EnsemblGenomes-Gn:BSU33870" /db_xref="EnsemblGenomes-Tr:CAB15392" /db_xref="GOA:O32246" /db_xref="InterPro:IPR029038" /db_xref="SubtiList:BG14082" /db_xref="UniProtKB/Swiss-Prot:O32246" /translation="MYCPQCGHQTDGGNFCEKCGSPLPGQSGHQHAAQTGAAAKQAAK QFGSFVLSVLKRPYQECKATGGEQLISAIITMVLFSLLTPLMFYILFSDGPGSVSFTA IFLEPTIYFILFLFGLHACIFFALKIAGNQVSFKDSFSRFGAFLIPFTAILILALFFF LLHTDICFTILAVGLIGAFFAIPPAMLSSYQHSYKGKVDFIYSTIVIYLIICVTFQLI IEHYVKEIFRYMLF*" /label="yvbI CDS" gene 3124486..3125184 /gene="yvbI" /locus_tag="BSU_33870" /old_locus_tag="BSU33870" /label="yvbI gene" downshifts 3125157 /Source="Nicolas_upshifts" /id="D1760" /incds=0 /nref=72 /ntot=203 /MaxReadThrough="1.50622" /MaxDrop="4.71846" /score="17.2112529" /energy="-17.2" /TU="U2671" /idTUdmin="U2671" /TUdmin="-23" /isTUend="FALSE" /label="downshifts" CDS complement(3125220..3127037) /gene="yvbJ" /locus_tag="BSU_33880" /old_locus_tag="BSU33880" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15155184" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391268.1" /db_xref="EnsemblGenomes-Gn:BSU33880" /db_xref="EnsemblGenomes-Tr:CAB15393" /db_xref="GOA:O32247" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR026870" /db_xref="SubtiList:BG14083" /db_xref="UniProtKB/Swiss-Prot:O32247" /translation="MLFCKNCGSQNNEGAKFCKQCGTPIGGGSKQANQETASTAETRQ APRKPIPKKTIILWSSIAAACVILFAAYKTGAYFTSKDRLVDKFEQAVNDGDQDQIAT LLTPVNDNLKLTKNNVKPFLTYLKDHPDKKDELFASLRDETAQKDIVYAEKDGKSLLV FDHYDLKVAPVYFEVSSNYKNTDLYVNKEEAGSVKKADQAQTLGPYIPGEYTVSAKLK NDVVDLVKKEDIQAIGDSSFRVDLSLEADDVTFSLANDIKSGKGDLLINGKSIHKDPF KSVTYGPLLTDGSMTASVEAEFPWGKTKTAGVPIDDKEMELTLIPDQDTQEQIMNTIV KTTKQYSKALSDGNTAQMTEASANWKAETKDTVDSMKSADSYLKDRYLETDFDLDTFA LSQKNDGTWQVSVTGKELHQSSSYNDYTKSEMTDDSPSYEYLLSYDKKQKKWIFEDAE STFESAGTNIKKIKNDKPETYTSAWAGSKNKGSESSASGDVTDEQVTLFMGSYLQSQA DAVNQNNFSLMEDSLEKGSSLYSDQQHLVSKLNKEGTTEDFNNYEVKSWSQNGSAITI KTYEEFYITKSGGSPKLRTYNWTYTGVVKNGRIYLTSIQ*" /label="yvbJ CDS" gene complement(3125220..3127037) /gene="yvbJ" /locus_tag="BSU_33880" /old_locus_tag="BSU33880" /label="yvbJ gene" downshifts complement(3125239) /Source="Nicolas_upshifts" /id="D1761" /incds=0 /nref=31 /ntot=189 /MaxReadThrough="2.6958" /MaxDrop="3.67366" /score="15.9345511" /energy="-17.2" /TU="NA" /idTUdmin="U2673" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" downshifts complement(3125410) /Source="Nicolas_upshifts" /id="D1762" /incds=1 /nref=1 /ntot=106 /MaxReadThrough="4.6758" /MaxDrop="2.2812" /score="15.9345511" /energy="-17.2" /TU="U2673" /idTUdmin="U2673" /TUdmin="-176" /isTUend="FALSE" /label="downshifts" misc_feature complement(3127079..3127098) /Source="Nicolas_upshift_promotors" /id="U2673" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.546453546453546" /psig="0.995004995004995" /xcortree=2319 /SigmaFactorBS="cctttttagtctgatagacatttaattttttcattcgttccc aatttcattctgTTTTATTATAAAATATGAAAagcagtaaatgttatcaaattagtag a" /listShort="yvbJ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" misc_feature 3127083..3127102 /Source="Nicolas_upshift_promotors" /id="U2672" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.679320679320679" /psig="0.994005994005994" /xcortree=3040 /SigmaFactorBS="aaaataacatgactttcctcctattctactaatttgataaca tttactgcttttcATATTTTATAATAAAACAGAatgaaattgggaacgaatgaaaaaa t" /listShort="yvbK" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3127088 /Source="Nicolas_upshifts" /id="U2672" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.679320679320679" /psig="0.994005994005994" /xcortree=3040 /SigmaFactorBS="aaaataacatgactttcctcctattctactaatttgataaca tttactgcttttcATATTTTATAATAAAACAGAatgaaattgggaacgaatgaaaaaa t" /listShort="yvbK" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(3127092) /Source="Nicolas_upshifts" /id="U2673" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.546453546453546" /psig="0.995004995004995" /xcortree=2319 /SigmaFactorBS="cctttttagtctgatagacatttaattttttcattcgttccc aatttcattctgTTTTATTATAAAATATGAAAagcagtaaatgttatcaaattagtag a" /listShort="yvbJ" /GFF_Attribute="listLong" /label="upshifts" CDS 3127157..3127624 /gene="yvbK" /locus_tag="BSU_33890" /old_locus_tag="BSU33890" /EC_number="2.3.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acyltransferase" /protein_id="NP_391269.1" /db_xref="EnsemblGenomes-Gn:BSU33890" /db_xref="EnsemblGenomes-Tr:CAB15394" /db_xref="GOA:O32248" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="PDB:1YVK" /db_xref="SubtiList:BG14084" /db_xref="UniProtKB/Swiss-Prot:O32248" /translation="MNMQKLRIELGEETNDELYDLLLLADPSKDIVDEYLERGECYTA WAGDELAGVYVLLKTRPQTVEIVNIAVKESLQKKGFGKQLVLDAIEKAKKLGADTIEI GTGNSSIHQLSLYQKCGFRIQAIDHDFFLRHYDEDIFENGIQCRDMVRLYLDL*" /label="yvbK CDS" gene 3127157..3127624 /gene="yvbK" /locus_tag="BSU_33890" /old_locus_tag="BSU33890" /label="yvbK gene" downshifts 3127621 /Source="Nicolas_upshifts" /id="D1763" /incds=0 /nref=199 /ntot=250 /MaxReadThrough="1.84358" /MaxDrop="5.3321" /score="15.9040274" /energy="-13.3" /TU="U2672" /idTUdmin="U2672" /TUdmin="-23" /isTUend="FALSE" /label="downshifts" CDS complement(3127669..3128961) /gene="eno" /locus_tag="BSU_33900" /old_locus_tag="BSU33900" /EC_number="4.2.1.11" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8021172, 9588797, 12682299, 15301535, 19193632, 19215769, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8021172, 9588797, 12682299, 15301535, 19193632, 19215769, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="enolase" /protein_id="NP_391270.1" /db_xref="EnsemblGenomes-Gn:BSU33900" /db_xref="EnsemblGenomes-Tr:CAB15395" /db_xref="GOA:P37869" /db_xref="InterPro:IPR000941" /db_xref="InterPro:IPR020809" /db_xref="InterPro:IPR020810" /db_xref="InterPro:IPR020811" /db_xref="InterPro:IPR029017" /db_xref="InterPro:IPR034390" /db_xref="InterPro:IPR036849" /db_xref="PDB:4A3R" /db_xref="SubtiList:BG10899" /db_xref="UniProtKB/Swiss-Prot:P37869" /translation="MPYIVDVYAREVLDSRGNPTVEVEVYTETGAFGRALVPSGASTG EYEAVELRDGDKDRYLGKGVLTAVNNVNEIIAPELLGFDVTEQNAIDQLLIELDGTEN KGKLGANAILGVSMACARAAADFLQIPLYQYLGGFNSKTLPVPMMNIVNGGEHADNNV DIQEFMIMPVGAPNFREALRMGAQIFHSLKSVLSAKGLNTAVGDEGGFAPNLGSNEEA LQTIVEAIEKAGFKPGEEVKLAMDAASSEFYNKEDGKYHLSGEGVVKTSAEMVDWYEE LVSKYPIISIEDGLDENDWEGHKLLTERLGKKVQLVGDDLFVTNTKKLSEGIKNGVGN SILIKVNQIGTLTETFDAIEMAKRAGYTAVISHRSGETEDSTIADIAVATNAGQIKTG APSRTDRVAKYNQLLRIEDQLAETAQYHGINSFYNLNK*" /label="eno CDS" gene complement(3127669..3128961) /gene="eno" /locus_tag="BSU_33900" /old_locus_tag="BSU33900" /label="eno gene" downshifts complement(3127679) /Source="Nicolas_upshifts" /id="D1764" /incds=0 /nref=254 /ntot=269 /MaxReadThrough="2.21852" /MaxDrop="9.34136" /score="29.8674712" /energy="-15" /TU="NA" /idTUdmin="U2674" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" CDS complement(3128991..3130526) /gene="pgm" /locus_tag="BSU_33910" /old_locus_tag="BSU33910" /EC_number="5.4.2.12" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9830105, 10869096, 12682299, 19193632, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9830105, 10869096, 12682299, 19193632, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoglycerate mutase" /protein_id="NP_391271.1" /db_xref="EnsemblGenomes-Gn:BSU33910" /db_xref="EnsemblGenomes-Tr:CAB15396" /db_xref="GOA:P39773" /db_xref="InterPro:IPR005995" /db_xref="InterPro:IPR006124" /db_xref="InterPro:IPR011258" /db_xref="InterPro:IPR017849" /db_xref="InterPro:IPR017850" /db_xref="InterPro:IPR036646" /db_xref="SubtiList:BG10898" /db_xref="UniProtKB/Swiss-Prot:P39773" /translation="MSKKPAALIILDGFGLRNETVGNAVALAKKPNFDRYWNQYPHQT LTASGEAVGLPEGQMGNSEVGHLNIGAGRIVYQSLTRVNVAIREGEFERNQTFLDAIS NAKENNKALHLFGLLSDGGVHSHINHLFALLKLAKKEGLTKVYIHGFLDGRDVGPQTA KTYINQLNDQIKEIGVGEIASISGRYYSMDRDKRWDRVEKAYRAMAYGEGPSYRSALD VVDDSYANGIYDEFVIPSVITKENGEPVAKIQDGDSVIFYNFRPDRAIQISNTFTNKD FRDFDRGENYPKNLYFVCLTHFSETVDGYVAFKPINLDNTVGEVLSQHGLKQLRIAET EKYPHVTFFMSGGREAEFPGEERILINSPKVATYDLKPEMSAYEVKDALVKEIEADKH DAIILNFANPDMVGHSGMVEPTIKAIEAVDECLGEVVDAILAKGGHAIITADHGNADI LITESGEPHTAHTTNPVPVIVTKEGITLREGGILGDLAPTLLDLLGVEKPKEMTGTSL IQK*" /label="pgm CDS" gene complement(3128991..3130526) /gene="pgm" /locus_tag="BSU_33910" /old_locus_tag="BSU33910" /label="pgm gene" CDS complement(3130519..3131280) /gene="tpiA" /locus_tag="BSU_33920" /old_locus_tag="BSU33920" /EC_number="5.3.1.1" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8021172, 12682299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="triose phosphate isomerase" /protein_id="NP_391272.1" /db_xref="EnsemblGenomes-Gn:BSU33920" /db_xref="EnsemblGenomes-Tr:CAB15397" /db_xref="GOA:P27876" /db_xref="InterPro:IPR000652" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR020861" /db_xref="InterPro:IPR022896" /db_xref="InterPro:IPR035990" /db_xref="SubtiList:BG10897" /db_xref="UniProtKB/Swiss-Prot:P27876" /translation="MRKPIIAGNWKMNKTLGEAVSFVEEVKSSIPAADKAEAVVCAPA LFLEKLASAVKGTDLKVGAQNMHFEESGAFTGEISPVALKDLGVDYCVIGHSERREMF AETDETVNKKAHAAFKHGIVPIICVGETLEEREAGKTNDLVADQVKKGLAGLSEEQVA ASVIAYEPIWAIGTGKSSTAKDANDVCAHIRKTVAESFSQEAADKLRIQYGGSVKPAN IKEYMAESDIDGALVGGASLEPQSFVQLLEEGQYE*" /label="tpiA CDS" gene complement(3130519..3131280) /gene="tpiA" /locus_tag="BSU_33920" /old_locus_tag="BSU33920" /label="tpiA gene" CDS complement(3131311..3132495) /gene="pgk" /locus_tag="BSU_33930" /old_locus_tag="BSU33930" /EC_number="2.7.2.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10559176, 12682299, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10559176, 12682299, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoglycerate kinase" /protein_id="NP_391273.1" /db_xref="EnsemblGenomes-Gn:BSU33930" /db_xref="EnsemblGenomes-Tr:CAB15398" /db_xref="GOA:P40924" /db_xref="InterPro:IPR001576" /db_xref="InterPro:IPR015824" /db_xref="InterPro:IPR015911" /db_xref="InterPro:IPR036043" /db_xref="SubtiList:BG11062" /db_xref="UniProtKB/Swiss-Prot:P40924" /translation="MNKKTLKDIDVKGKVVFCRVDFNVPMKDGEVTDDTRIRAALPTI KHLADQGAKVLLASHLGRPKGEVVEELRLTPVAARLGELLGKEVKKADEAYGDAVKAQ ISEMKDGDVLVLENVRFYPGEEKNDPELAKAFAELADVYVNDAFGAAHRAHASTAGIA EHLPAVAGFLMEKELDVLGKAVSNPDRPFTAIIGGAKVKDKIGVIESLLDKVDNLIIG GGLAYTFVKALGYEVGKSLLEEDKIELAKSFMDRAKEKGVNFYMPEDVLVADDFSNDA NVKIVPISEIPSDLEAIDIGTKTRETYADVIKNSKLVVWNGPMGVFEIDLFAQGTKAV AEALAEAKDTYSVIGGGDSAAAVEKFGLADKMSHISTGGGASLEFMEGKELPGVAALN DK*" /label="pgk CDS" gene complement(3131311..3132495) /gene="pgk" /locus_tag="BSU_33930" /old_locus_tag="BSU33930" /label="pgk gene" S_feature complement(3132496..3132736) /Source="Nicolas_S_feature" /locus_tag="new_3481382_3481622_c" /HighExp="Lbstat, Lbtran, C90, LBGtran, LBGexp, G150, M40t45, LPhT, M0t45, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-, SigA, SigK" /TUshortPSig="0.979, 0.136, 0.993, 0.902" /TUlongSig="NA" /TUlongPSig="NA" /label="S1300" upshifts complement(3132736) /Source="Nicolas_upshifts" /id="U2674" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.93906093906094" /psig="0.97902097902098" /xcortree=2685 /SigmaFactorBS="ggacctgACTTGgttctttcgaatagaAGCGCTATAATGAAA GCGGAcaagggaaggggacggactccctttccctttttccatgaagaccggctttcag a" /listShort="S1300, pgk, tpiA, pgm, eno" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3132738..3132811) /Source="Nicolas_S_feature" /locus_tag="new_3481624_3481697_c" /HighExp="C90, LBGtran, Lbstat, LBGexp, Lbtran, G150, M40t45, Etha, ferm, Gly" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA, SigK" /TUshortPSig="0.136, 0.993, 0.902" /TUlongSig="NA" /TUlongPSig="NA" /label="S1301" promotor_-10 complement(3132750..3132769) /Source="Nicolas_upshift_promotors" /id="U2674" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.93906093906094" /psig="0.97902097902098" /xcortree=2685 /SigmaFactorBS="ggacctgACTTGgttctttcgaatagaAGCGCTATAATGAAA GCGGAcaagggaaggggacggactccctttccctttttccatgaagaccggctttcag a" /listShort="S1300, pgk, tpiA, pgm, eno" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3132785..3132789) /Source="Nicolas_upshift_promotors" /id="U2674" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.93906093906094" /psig="0.97902097902098" /xcortree=2685 /SigmaFactorBS="ggacctgACTTGgttctttcgaatagaAGCGCTATAATGAAA GCGGAcaagggaaggggacggactccctttccctttttccatgaagaccggctttcag a" /listShort="S1300, pgk, tpiA, pgm, eno" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3132812..3133819) /gene="gapA" /locus_tag="BSU_33940" /old_locus_tag="BSU33940" /EC_number="1.2.1.12" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9588797, 10799476, 12123463, 12634343, 17142398, 27449348, 28760849" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9588797, 10799476, 12123463, 12634343, 17142398, 27449348, 28760849; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glyceraldehyde-3-phosphate dehydrogenase (NAD-dependent, glycolytic)" /protein_id="NP_391274.1" /db_xref="EnsemblGenomes-Gn:BSU33940" /db_xref="EnsemblGenomes-Tr:CAB15399" /db_xref="GOA:P09124" /db_xref="InterPro:IPR006424" /db_xref="InterPro:IPR020828" /db_xref="InterPro:IPR020829" /db_xref="InterPro:IPR020830" /db_xref="InterPro:IPR020831" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10827" /db_xref="UniProtKB/Swiss-Prot:P09124" /translation="MAVKVGINGFGRIGRNVFRAALNNPEVEVVAVNDLTDANMLAHL LQYDSVHGKLDAEVSVDGNNLVVNGKTIEVSAERDPAKLSWGKQGVEIVVESTGFFTK RADAAKHLEAGAKKVIISAPANEEDITIVMGVNEDKYDAANHDVISNASCTTNCLAPF AKVLNDKFGIKRGMMTTVHSYTNDQQILDLPHKDYRRARAAAENIIPTSTGAAKAVSL VLPELKGKLNGGAMRVPTPNVSLVDLVAELNQEVTAEEVNAALKEAAEGDLKGILGYS EEPLVSGDYNGNKNSSTIDALSTMVMEGSMVKVISWYDNESGYSNRVVDLAAYIAKKG L*" /label="gapA CDS" gene complement(3132812..3133819) /gene="gapA" /locus_tag="BSU_33940" /old_locus_tag="BSU33940" /label="gapA gene" promotor_-35 3133738..3133741 /Source="Nicolas_upshift_promotors" /id="U2675" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.985014985014985" /psig="0.001998001998002" /xcortree=75 /SigmaFactorBS="catgttagcatctgttaaatcgttaaccgctactacctCAAC ttcaggattgtttaatGCTgcgcggaatacgttacgtccaatacgaccaaaaccgtta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3133758..3133760 /Source="Nicolas_upshift_promotors" /id="U2675" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.985014985014985" /psig="0.001998001998002" /xcortree=75 /SigmaFactorBS="catgttagcatctgttaaatcgttaaccgctactacctCAAC ttcaggattgtttaatGCTgcgcggaatacgttacgtccaatacgaccaaaaccgtta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3133760 /Source="Nicolas_upshifts" /id="U2675" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.985014985014985" /psig="0.001998001998002" /xcortree=75 /SigmaFactorBS="catgttagcatctgttaaatcgttaaccgctactacctCAAC ttcaggattgtttaatGCTgcgcggaatacgttacgtccaatacgaccaaaaccgtta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3133866..3134888) /gene="cggR" /locus_tag="BSU_33950" /old_locus_tag="BSU33950" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11489127, 12622823, 17142398, 17293407, 18052209, 18554327" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11489127, 12622823, 17142398, 17293407, 18052209, 18554327; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of gapA" /protein_id="NP_391275.1" /db_xref="EnsemblGenomes-Gn:BSU33950" /db_xref="EnsemblGenomes-Tr:CAB15400" /db_xref="GOA:O32253" /db_xref="InterPro:IPR007324" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2OKG" /db_xref="PDB:3BXE" /db_xref="PDB:3BXF" /db_xref="PDB:3BXG" /db_xref="PDB:3BXH" /db_xref="SubtiList:BG14085" /db_xref="UniProtKB/Swiss-Prot:O32253" /translation="MNQLIQAQKKLLPDLLLVMQKRFEILQYIRLTEPIGRRSLSASL GISERVLRGEVQFLKEQNLVDIKTNGMTLTEEGYELLSVLEDTMKDVLGLTLLEKTLK ERLNLKDAIIVSGDSDQSPWVKKEMGRAAVACMKKRFSGKNIVAVTGGTTIEAVAEMM TPDSKNRELLFVPARGGLGEDVKNQANTICAHMAEKASGTYRLLFVPGQLSQGAYSSI IEEPSVKEVLNTIKSASMLVHGIGEAKTMAQRRNTPLEDLKKIDDNDAVTEAFGYYFN ADGEVVHKVHSVGMQLDDIDAIPDIIAVAGGSSKAEAIEAYFKKPRNTVLVTDEGAAK KLLRDE*" /label="cggR CDS" gene complement(3133866..3134888) /gene="cggR" /locus_tag="BSU_33950" /old_locus_tag="BSU33950" /label="cggR gene" upshifts complement(3133882) /Source="Nicolas_upshifts" /id="U2676" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.313686313686314" /psig="0.135864135864136" /xcortree=2684 /SigmaFactorBS="cttactttaaaaagccacgcaacacggttctCGtcacagacg aaggagccgcAaagaagttattaagggatgaataatccctcaatataaatatctctca c" /listShort="gapA, S1301, S1300, pgk, tpiA, pgm, eno" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3133910..3133911) /Source="Nicolas_upshift_promotors" /id="U2676" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.313686313686314" /psig="0.135864135864136" /xcortree=2684 /SigmaFactorBS="cttactttaaaaagccacgcaacacggttctCGtcacagacg aaggagccgcAaagaagttattaagggatgaataatccctcaatataaatatctctca c" /listShort="gapA, S1301, S1300, pgk, tpiA, pgm, eno" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3134889..3135000) /Source="Nicolas_S_feature" /locus_tag="new_3483775_3483886_c" /HighExp="LPhT, C90, LBGtran, Heat, BI, LBGexp, Lbstat, Sw, Lbexp, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.993, 0.902" /TUlongSig="NA" /TUlongPSig="NA" /label="S1302" downshifts 3134926 /Source="Nicolas_upshifts" /id="D1765" /incds=0 /nref=3 /ntot=50 /MaxReadThrough="4.48989" /MaxDrop="5.24842" /score="-9.71393179" /energy="-11.8" /TU="NA" /idTUdmin="U2675" /TUdmin=1078 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3134981..3135000) /Source="Nicolas_upshift_promotors" /id="U2677" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.561438561438561" /psig="0.993006993006993" /xcortree=5 /SigmaFactorBS="tgaaaactctgcgaatattgtcgatgaattggctcttaaCAG TTGAAtaaacaattccacCCTGTTAAAATAATTAAAGAaagcagaaatgatttttttt g" /listShort="S1302, cggR, gapA, S1301, S1300, pgk, tpiA, pgm, eno" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3135000) /Source="Nicolas_upshifts" /id="U2677" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.561438561438561" /psig="0.993006993006993" /xcortree=5 /SigmaFactorBS="tgaaaactctgcgaatattgtcgatgaattggctcttaaCAG TTGAAtaaacaattccacCCTGTTAAAATAATTAAAGAaagcagaaatgatttttttt g" /listShort="S1302, cggR, gapA, S1301, S1300, pgk, tpiA, pgm, eno" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3135002..3135112) /Source="Nicolas_S_feature" /locus_tag="new_3483888_3483998_c" /HighExp="S8, S6, S7, BT, B36, S5, S4, S3, B60, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.902" /TUlongSig="NA" /TUlongPSig="NA" /label="S1303" promotor_-35 complement(3135014..3135021) /Source="Nicolas_upshift_promotors" /id="U2677" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.561438561438561" /psig="0.993006993006993" /xcortree=5 /SigmaFactorBS="tgaaaactctgcgaatattgtcgatgaattggctcttaaCAG TTGAAtaaacaattccacCCTGTTAAAATAATTAAAGAaagcagaaatgatttttttt g" /listShort="S1302, cggR, gapA, S1301, S1300, pgk, tpiA, pgm, eno" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3135095..3135114) /Source="Nicolas_upshift_promotors" /id="U2678" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.902097902097902" /psig="0.902097902097902" /xcortree=1316 /SigmaFactorBS="acagccctttctacgggaagggctgtttatattgGGATGCAC CAtttggcgctttcTGTATAAGATAAAGATATATaggataaaatattgctggataaaa c" /listShort="S1303, S1302, cggR, gapA, S1301, S1300" /listLong="pgk, tpiA, pgm, eno" /label="promotor_-10" upshifts complement(3135110) /Source="Nicolas_upshifts" /id="U2678" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.902097902097902" /psig="0.902097902097902" /xcortree=1316 /SigmaFactorBS="acagccctttctacgggaagggctgtttatattgGGATGCAC CAtttggcgctttcTGTATAAGATAAAGATATATaggataaaatattgctggataaaa c" /listShort="S1303, S1302, cggR, gapA, S1301, S1300" /listLong="pgk, tpiA, pgm, eno" /label="upshifts" promotor_-35 complement(3135127..3135136) /Source="Nicolas_upshift_promotors" /id="U2678" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.902097902097902" /psig="0.902097902097902" /xcortree=1316 /SigmaFactorBS="acagccctttctacgggaagggctgtttatattgGGATGCAC CAtttggcgctttcTGTATAAGATAAAGATATATaggataaaatattgctggataaaa c" /listShort="S1303, S1302, cggR, gapA, S1301, S1300" /listLong="pgk, tpiA, pgm, eno" /label="promotor_-35" CDS complement(3135186..3136580) /gene="araE" /locus_tag="BSU_33960" /old_locus_tag="BSU33960" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9620981, 10417639, 15849754, 16850406, 20693325" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9620981, 10417639, 15849754, 16850406, 20693325; Product type t : transporter" /codon_start=1 /transl_table=11 /product="arabinose-related compounds permease" /protein_id="NP_391276.1" /db_xref="EnsemblGenomes-Gn:BSU33960" /db_xref="EnsemblGenomes-Tr:CAB15401" /db_xref="GOA:P96710" /db_xref="InterPro:IPR003663" /db_xref="InterPro:IPR005828" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11907" /db_xref="UniProtKB/Swiss-Prot:P96710" /translation="MKNTPTQLEPNVPVTRSHSMGFVILISCAAGLGGLLYGYDTAVI SGAIGFLKDLYSLSPFMEGLVISSIMIGGVVGVGISGFLSDRFGRRKILMTAALLFAI SAIVSALSQDVSTLIIARIIGGLGIGMGSSLSVTYITEAAPPAIRGSLSSLYQLFTIL GISATYFINLAVQRSGTYEWGVHTGWRWMLAYGMVPSVIFFLVLLVVPESPRWLAKAG KTNEALKILTRINGETVAKEELKNIENSLKIEQMGSLSQLFKPGLRKALVIGILLALF NQVIGMNAITYYGPEIFKMMGFGQNAGFVTTCIVGVVEVIFTVIAVLLIDKVGRKKLM SIGSAFMAIFMILIGTSFYFELTSGIMMIVLILGFVAAFCVSVGPITWIMISEIFPNH LRARAAGIATIFLWGANWAIGQFVPMMIDSFGLAYTFWIFAVINILCFLFVVTICPET KNKSLEEIEKLWIK*" /label="araE CDS" gene complement(3135186..3136580) /gene="araE" /locus_tag="BSU_33960" /old_locus_tag="BSU33960" /label="araE gene" downshifts complement(3135200) /Source="Nicolas_upshifts" /id="D1766" /incds=0 /nref=1 /ntot=23 /MaxReadThrough="1.15614" /MaxDrop="3.28809" /score="1.06999853" /energy="-14.6" /TU="NA" /idTUdmin="U2679" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3136679..3136698) /Source="Nicolas_upshift_promotors" /id="U2679" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig="0.999000999001" /xcortree=348 /SigmaFactorBS="tttcagtatatcacagcgttctttgtaagaaaaCATTGACAg aaaatgcaaacaaGATTATTCTATATTTGTACGtactaattaaatgtaattttcgtta a" /listShort="araE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3136693) /Source="Nicolas_upshifts" /id="U2679" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig="0.999000999001" /xcortree=348 /SigmaFactorBS="tttcagtatatcacagcgttctttgtaagaaaaCATTGACAg aaaatgcaaacaaGATTATTCTATATTTGTACGtactaattaaatgtaattttcgtta a" /listShort="araE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3136713..3136720) /Source="Nicolas_upshift_promotors" /id="U2679" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig="0.999000999001" /xcortree=348 /SigmaFactorBS="tttcagtatatcacagcgttctttgtaagaaaaCATTGACAg aaaatgcaaacaaGATTATTCTATATTTGTACGtactaattaaatgtaattttcgtta a" /listShort="araE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3136720..3136727 /Source="Nicolas_upshift_promotors" /id="U2680" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.47052947052947" /psig=1 /xcortree=2310 /SigmaFactorBS="tatagaataatcttgtttgcattttctgtcaatGTTTTCTTa caaagaacgctgTGATATACTGAAATTTGTCCgtatacattttggaggaatggatatg t" /listShort="araR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3136741..3136760 /Source="Nicolas_upshift_promotors" /id="U2680" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.47052947052947" /psig=1 /xcortree=2310 /SigmaFactorBS="tatagaataatcttgtttgcattttctgtcaatGTTTTCTTa caaagaacgctgTGATATACTGAAATTTGTCCgtatacattttggaggaatggatatg t" /listShort="araR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3136747 /Source="Nicolas_upshifts" /id="U2680" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.47052947052947" /psig=1 /xcortree=2310 /SigmaFactorBS="tatagaataatcttgtttgcattttctgtcaatGTTTTCTTa caaagaacgctgTGATATACTGAAATTTGTCCgtatacattttggaggaatggatatg t" /listShort="araR" /GFF_Attribute="listLong" /label="upshifts" CDS 3136784..3137872 /gene="araR" /locus_tag="BSU_33970" /old_locus_tag="BSU33970" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10417639, 11418559, 12949161, 14973026, 16585763, 17617643, 22281747, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10417639, 11418559, 12949161, 14973026, 16585763, 17617643, 22281747, 26735940; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of the ara regulon (LacI family)" /protein_id="NP_391277.2" /db_xref="EnsemblGenomes-Gn:BSU33970" /db_xref="EnsemblGenomes-Tr:CAB15402" /db_xref="GOA:P96711" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR028082" /db_xref="InterPro:IPR033532" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:3TB6" /db_xref="PDB:4EGY" /db_xref="PDB:4EGZ" /db_xref="PDB:4H0E" /db_xref="PDB:5D4R" /db_xref="PDB:5D4S" /db_xref="SubtiList:BG11913" /db_xref="UniProtKB/Swiss-Prot:P96711" /translation="MLPKYAQVKEEISSWINQGKILPDQKIPTENELMQQFGVSRHTI RKAIGDLVSQGLLYSVQGGGTFVASRSAKSALHSNKTIGVLTTYISDYIFPSIIRGIE SYLSEQGYSMLLTSTNNNPDNERRGLENLLSQHIDGLIVEPTKSALQTPNIGYYLNLE KNGIPFAMINASYAELAAPSFTLDDVKGGMMAAEHLLSLGHTHMMGIFKADDTQGVKR MNGFIQAHRERELFPSPDMIVTFTTEEKESKLLEKVKATLEKNSKHMPTAILCYNDEI ALKVIDMLREMDLKVPEDMSIVGYDDSHFAQISEVKLTSVKHPKSVLGKAAAKYVIDC LEHKKPKQEDVIFEPELIIRQSARKLNE*" /label="araR CDS" gene 3136784..3137872 /gene="araR" /locus_tag="BSU_33970" /old_locus_tag="BSU33970" /label="araR gene" downshifts 3137852 /Source="Nicolas_upshifts" /id="D1767" /incds=0 /nref=202 /ntot=247 /MaxReadThrough="1.17419" /MaxDrop="4.76041" /score="20.2322165" /energy="-13.6" /TU="NA" /idTUdmin="U2680" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3137921..3138931) /gene="yvbT" /locus_tag="BSU_33980" /old_locus_tag="BSU33980" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9836433; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative alkanal monooxygenase" /protein_id="NP_391278.1" /db_xref="EnsemblGenomes-Gn:BSU33980" /db_xref="EnsemblGenomes-Tr:CAB15403" /db_xref="GOA:O32254" /db_xref="InterPro:IPR011251" /db_xref="InterPro:IPR019949" /db_xref="InterPro:IPR036661" /db_xref="SubtiList:BG14086" /db_xref="UniProtKB/Swiss-Prot:O32254" /translation="MSNNQRKDTLLSVLNLSPVVQGGTIAESFRNSMDLARRAEEWGY HRYWLAEHHNIEGVASSATAVLIGHIAGGTKKIRVGSGGIMLPNHSSLVIAEQFGTLE TLYPGRIDLGLGRAPGTDQLTARALRRNINSGEDFPEQLEELRNYFKPSGNVRNQVRA IPGEGIDVPIWLLGSSGFSARLAGELGLPFAFAAHFSPANTVPALELYRNSFTPSDVL DEPYAMVGVTIIAADTNEKAQHLATSHYQRFLDLVRGTPNQLKPPVEDMDQIWSPYEK AMVNEQLSSTIVGGPEEVKAKLEDFVKTTQADEIMVNSETFEHADRMRSFEIIADVWK NR*" /label="yvbT CDS" gene complement(3137921..3138931) /gene="yvbT" /locus_tag="BSU_33980" /old_locus_tag="BSU33980" /label="yvbT gene" downshifts complement(3137928) /Source="Nicolas_upshifts" /id="D1768" /incds=0 /nref=200 /ntot=252 /MaxReadThrough="1.53983" /MaxDrop="7.63266" /score="27.2032847" /energy="-14.2" /TU="NA" /idTUdmin="U2681" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(3138932..3139009) /Source="Nicolas_S_feature" /locus_tag="new_3487818_3487895_c" /HighExp="dia5, dia15, Diami, H2O2, Salt, Paraq, G180, Etha, G150, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1304" promotor_-10 complement(3138999..3139018) /Source="Nicolas_upshift_promotors" /id="U2681" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.912087912087912" /psig=1 /xcortree=2040 /SigmaFactorBS="ttatattgttcgaatttcatcgaatcaaatTCTTTTATtcct gaatgcagtTGTGTTATGGTGTGATAGAAgttctttcaatcatgacctgacagctttg g" /listShort="S1304, yvbT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3139009) /Source="Nicolas_upshifts" /id="U2681" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.912087912087912" /psig=1 /xcortree=2040 /SigmaFactorBS="ttatattgttcgaatttcatcgaatcaaatTCTTTTATtcct gaatgcagtTGTGTTATGGTGTGATAGAAgttctttcaatcatgacctgacagctttg g" /listShort="S1304, yvbT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3139032..3139039) /Source="Nicolas_upshift_promotors" /id="U2681" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.912087912087912" /psig=1 /xcortree=2040 /SigmaFactorBS="ttatattgttcgaatttcatcgaatcaaatTCTTTTATtcct gaatgcagtTGTGTTATGGTGTGATAGAAgttctttcaatcatgacctgacagctttg g" /listShort="S1304, yvbT" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3139088..3139966) /gene="yvbU" /locus_tag="BSU_33990" /old_locus_tag="BSU33990" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (LysR family)" /protein_id="NP_391279.1" /db_xref="EnsemblGenomes-Gn:BSU33990" /db_xref="EnsemblGenomes-Tr:CAB15404" /db_xref="GOA:O32255" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG14087" /db_xref="UniProtKB/Swiss-Prot:O32255" /translation="MTITQLKVFVKIAETGSFTKAGQALNMTQPAVSHAISAIEAELD VKLIIRDRRNGLMLTDTGKQILVHIREVLKGIEKVEQVAAAEKGLELGTIHIGTFSTA SAYFMPKLISEFKQKYPKLELVLHEGTVNEVKEWLHTRMIDVGILLYPTEEMEYIHLK KDKMAVVLRDDHPLASHSAITLKDLDHEPMIVCDGGYESPFIDMFRQAGATLHPAFTV YNINTSISMIREGLGLAILSEMSMSGMPLPEHVVTRELDPQVYRDVQLAVPSLKEASL AAKLFIEMAKELFGAE*" /label="yvbU CDS" gene complement(3139088..3139966) /gene="yvbU" /locus_tag="BSU_33990" /old_locus_tag="BSU33990" /label="yvbU gene" promotor_-35 3139624..3139630 /Source="Nicolas_upshift_promotors" /id="U2682" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.72927072927073" /psig="0.72927072927073" /xcortree=1209 /SigmaFactorBS="acgagctcaagtttcggatatttttgttTAAATTCactgatc agcttcgGCATAAAATAAGccgaggcagttgagaatgtgccgatatggatcgttccca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3139645..3139656 /Source="Nicolas_upshift_promotors" /id="U2682" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.72927072927073" /psig="0.72927072927073" /xcortree=1209 /SigmaFactorBS="acgagctcaagtttcggatatttttgttTAAATTCactgatc agcttcgGCATAAAATAAGccgaggcagttgagaatgtgccgatatggatcgttccca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3139656 /Source="Nicolas_upshifts" /id="U2682" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.72927072927073" /psig="0.72927072927073" /xcortree=1209 /SigmaFactorBS="acgagctcaagtttcggatatttttgttTAAATTCactgatc agcttcgGCATAAAATAAGccgaggcagttgagaatgtgccgatatggatcgttccca g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3140000..3140007 /Source="Nicolas_upshift_promotors" /id="U2684" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2018 /SigmaFactorBS="tcataacaatttacttatgctccttataaaaaagattCATTT TATttatcttatgttcTACCGTATCATATGATGGAAaagttctacaaggagtgaatga a" /listShort="cyeB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3140013..3140032) /Source="Nicolas_upshift_promotors" /id="U2683" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.732267732267732" /psig=1 /xcortree=1895 /SigmaFactorBS="ggagctgcttcattgttcattcactcctTGTAGaacttttcc atcaTATGATACGGTAGAACATAAgataaataaaatgaatcttttttataaggagcat a" /listShort="yvbU" /listLong="S1304, yvbT" /label="promotor_-10" upshifts complement(3140018) /Source="Nicolas_upshifts" /id="U2683" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.732267732267732" /psig=1 /xcortree=1895 /SigmaFactorBS="ggagctgcttcattgttcattcactcctTGTAGaacttttcc atcaTATGATACGGTAGAACATAAgataaataaaatgaatcttttttataaggagcat a" /listShort="yvbU" /listLong="S1304, yvbT" /label="upshifts" promotor_-10 3140021..3140040 /Source="Nicolas_upshift_promotors" /id="U2684" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2018 /SigmaFactorBS="tcataacaatttacttatgctccttataaaaaagattCATTT TATttatcttatgttcTACCGTATCATATGATGGAAaagttctacaaggagtgaatga a" /listShort="cyeB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3140023 /Source="Nicolas_upshifts" /id="U2684" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2018 /SigmaFactorBS="tcataacaatttacttatgctccttataaaaaagattCATTT TATttatcttatgttcTACCGTATCATATGATGGAAaagttctacaaggagtgaatga a" /listShort="cyeB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3140046..3140050) /Source="Nicolas_upshift_promotors" /id="U2683" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.732267732267732" /psig=1 /xcortree=1895 /SigmaFactorBS="ggagctgcttcattgttcattcactcctTGTAGaacttttcc atcaTATGATACGGTAGAACATAAgataaataaaatgaatcttttttataaggagcat a" /listShort="yvbU" /listLong="S1304, yvbT" /label="promotor_-35" CDS 3140066..3140983 /gene="cyeB" /locus_tag="BSU_34000" /old_locus_tag="BSU34000" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10844694, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="cysteine and O-acetylserine efflux permease" /protein_id="NP_391280.1" /db_xref="EnsemblGenomes-Gn:BSU34000" /db_xref="EnsemblGenomes-Tr:CAB15405" /db_xref="GOA:O32256" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG14088" /db_xref="UniProtKB/Swiss-Prot:O32256" /translation="MKQLPKTRTALLLAFLVIMWGVNWPLSKAALAYSPPLLFAGIRT LIGGLLLVIVALPRIHKLRLKETWPIYLVSALLNITLFYGLQTIGLNYLPAGLFSAIV FFQPVLMGVFSWLWLGESMFVMKVIGLILGFAGVAVISAAGFGGHISVIGVLLALGSA VSWALGTVYMKKTGSRVDSIWMVALQLTIGSVFLLISGFWTESFSAIQWTAPFITSLL FISVFVIALGWLVFFTLVGSGEASKVASYTFLIPLISIVASSIFLHEPLTLSLLAGLL LIVTSICLVNTKSKAQKAAAIGINEKAAQ*" /label="cyeB CDS" gene 3140066..3140983 /gene="cyeB" /locus_tag="BSU_34000" /old_locus_tag="BSU34000" /label="cyeB gene" downshifts 3140972 /Source="Nicolas_upshifts" /id="D1769" /incds=0 /nref=6 /ntot=15 /MaxReadThrough="2.97475" /MaxDrop="3.548" /score="22.9557936" /energy="-19.2" /TU="NA" /idTUdmin="U2684" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS complement(3141024..3142367) /gene="yvbW" /locus_tag="BSU_34010" /old_locus_tag="BSU34010" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 19258532, 25645558; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative leucine permease" /protein_id="NP_391281.1" /db_xref="EnsemblGenomes-Gn:BSU34010" /db_xref="EnsemblGenomes-Tr:CAB15406" /db_xref="GOA:O32257" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG14089" /db_xref="UniProtKB/Swiss-Prot:O32257" /translation="MKNDNQTLKRTMTSRHIMMMALGGAIGAGLFKGSSSAIDVAGPS VIIAYLLGGIILLFIMQGLAEMAVRNRNARTFRDLVQQVLGNYAAYFLDWIYWKMWVL NIAAEAVVAAIFIQYWLPGCPIWVLALGISLIVTIVNLLSVKIFAETEYWLAMIKITV IIIFIILGLLLLFVSFGDHTASGFSNLTDHGGFFPHGGTGLITAMLVVIYSYGGTEII GVTLAETKNPEKVVPKAVRSTLTRIVAFYLLPFFIIVSLIPWNQVNSVPESPFVMVFK MVGIPGADHIMNAVILLAIISSMNSGLYGSSRILYTQASDGRLPKVFSKLSSKNVPMF AILMCTSSLYIGVLISLFAGSQTFNYLMGSLGYTVLFIWLIIGFAHLKSRKQQTETPA YYVKWFPYTTWFAIVALLAILIGVIMTTSIVITGITAAIYLLITVAYLVKGRKHQ*" /label="yvbW CDS" gene complement(3141024..3142367) /gene="yvbW" /locus_tag="BSU_34010" /old_locus_tag="BSU34010" /label="yvbW gene" misc_RNA complement(3142436..3142671) /gene="tboX" /locus_tag="BSU_misc_RNA_56" /product="T-box riboswitch controlling synthesis of an amino acid transporter" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 18625071, 19258532; Product type n: RNA" /function="16.3: Control" /label="tboX RNA" gene complement(3142436..3142671) /gene="tboX" /locus_tag="BSU_misc_RNA_56" /label="tboX gene" downshifts complement(3142570) /Source="Nicolas_upshifts" /id="D1770" /incds=1 /nref=1 /ntot=104 /MaxReadThrough="5.18182" /MaxDrop="2.29735" /score="33.4262209" /energy="-24.4" /TU="U2685,U2689" /idTUdmin="U2689" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" S_feature complement(3142672..3142768) /Source="Nicolas_S_feature" /locus_tag="new_3491558_3491654_c" /HighExp="Cold, GM 120, C30, GM 90, C90, GM 15, GM 10, GM 25, HPh, GM 60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigA" /TUshortPSig="1, 0.994" /TUlongSig="SigA" /TUlongPSig=1 /label="S1305" CDS complement(3142769..3143803) /gene="yvbX" /locus_tag="BSU_34020" /old_locus_tag="BSU34020" /function="16.5: Explore" /function="16.13: Shape" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12177332; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative epimerase modification of peptidoglycan" /protein_id="NP_391282.1" /db_xref="EnsemblGenomes-Gn:BSU34020" /db_xref="EnsemblGenomes-Tr:CAB15407" /db_xref="GOA:O32258" /db_xref="InterPro:IPR001223" /db_xref="InterPro:IPR011583" /db_xref="InterPro:IPR017853" /db_xref="SubtiList:BG14090" /db_xref="UniProtKB/Swiss-Prot:O32258" /translation="MKKWLIIAVSLAIAIVLFMYTKGEAKAAGMTVGYTTGDTASYNS LTKYHTYMNAIATDTFAFEKNGQIIGDAPTKQLTYAKKKKIKTWAVISNYNDAIYDFD GDLASRVMSNKTAKKRFTDQLITLAKKHSYYGINIDFEAVNPEDRAAYSNFIQYVSQA LNKKHIKTMVSVPAKSADDKNDDWSWPYDYAKIGKYADFVQVMTYDEHGIWGEPGSVA STNWIKSSLQFSVKKIKANKVIMGIPAYGYDWDVKDGSTSTIREWNELKSLIKKQKAK PAFNKKSGSMTFSYVDKKKHKHVVWYENEKTVQTKSHLAKQYKIAGVSVYALGNESES FWKAIRKGTK*" /label="yvbX CDS" gene complement(3142769..3143803) /gene="yvbX" /locus_tag="BSU_34020" /old_locus_tag="BSU34020" /label="yvbX gene" promotor_-10 complement(3143825..3143843) /Source="Nicolas_upshift_promotors" /id="U2685" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2815 /SigmaFactorBS="catatgccgggctttttgcttgaaaaaaCTTCAACTtccaat tttttgGCCGATGAGAAGAGTATGActtgatacaggaggaaatgcgatgaaaaaatgg c" /listShort="yvbX, S1305, NA, yvbW" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3143831) /Source="Nicolas_upshifts" /id="U2685" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2815 /SigmaFactorBS="catatgccgggctttttgcttgaaaaaaCTTCAACTtccaat tttttgGCCGATGAGAAGAGTATGActtgatacaggaggaaatgcgatgaaaaaatgg c" /listShort="yvbX, S1305, NA, yvbW" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3143856..3143863) /Source="Nicolas_upshift_promotors" /id="U2685" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2815 /SigmaFactorBS="catatgccgggctttttgcttgaaaaaaCTTCAACTtccaat tttttgGCCGATGAGAAGAGTATGActtgatacaggaggaaatgcgatgaaaaaatgg c" /listShort="yvbX, S1305, NA, yvbW" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3143911..3144633) /gene="lutC" /locus_tag="BSU_34030" /old_locus_tag="BSU34030" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:22427629, 24196425, 24274019" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22427629, 24196425, 24274019; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="component of an iron-sulfur oxidase for L-lactate utilization" /protein_id="NP_391283.1" /db_xref="EnsemblGenomes-Gn:BSU34030" /db_xref="EnsemblGenomes-Tr:CAB15408" /db_xref="InterPro:IPR003741" /db_xref="InterPro:IPR022823" /db_xref="SubtiList:BG14091" /db_xref="UniProtKB/Swiss-Prot:O32259" /translation="MTKGTIQNQESFLNRIASSLGRERRTGGVAVPEWAHQPQYKTLE GYSADDLVTVLKNHCVKIHTELIETDSTGLYDALREQVSRFSGGPVIIPKDPRFEEYG LKSLLTKDWPSEGTPVWEWDADKGEENIKKAEQANVGITFSEITLAESGTVVLFSSKD IGRSVSLLPTTYIAIVPKSSIVPRMTQASDIIRQNIANGVTVPSCINYITGPSNSADI EMDLVVGVHGPVKAAYILVSDR*" /label="lutC CDS" gene complement(3143911..3144633) /gene="lutC" /locus_tag="BSU_34030" /old_locus_tag="BSU34030" /label="lutC gene" downshifts complement(3143927) /Source="Nicolas_upshifts" /id="D1771" /incds=0 /nref=194 /ntot=266 /MaxReadThrough="4.5919" /MaxDrop="7.41457" /score="25.5917046" /energy="-15.7" /TU="U2689" /idTUdmin="U2689" /TUdmin="-1423" /isTUend="FALSE" /label="downshifts" CDS complement(3144633..3146072) /gene="lutB" /locus_tag="BSU_34040" /old_locus_tag="BSU34040" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16513748, 19201793, 19508281, 22427629, 24196425, 24274019, 28032445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16513748, 19201793, 19508281, 22427629, 24196425, 24274019, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="component of an iron-sulfur oxidase linked to L-lactate utilization" /protein_id="NP_391284.1" /db_xref="EnsemblGenomes-Gn:BSU34040" /db_xref="EnsemblGenomes-Tr:CAB15409" /db_xref="GOA:O07021" /db_xref="InterPro:IPR003741" /db_xref="InterPro:IPR004452" /db_xref="InterPro:IPR009051" /db_xref="InterPro:IPR017896" /db_xref="InterPro:IPR017900" /db_xref="InterPro:IPR022825" /db_xref="InterPro:IPR024569" /db_xref="SubtiList:BG12448" /db_xref="UniProtKB/Swiss-Prot:O07021" /translation="MAMKIGTDAFKERVSQGIDNEFMRGAVSGAQERLRTRRLEAAEE LGNWEEWRSLSEEIRQHVLENLDFYLGQLAENVAKRGGHVYFAKTAEEASSYIRDVIQ KKNGKKIVKSKSMVTEEINLNEVLEKEGCEVVETDLGEYILQIDDHDPPSHIVAPALH KNKEQIRDVFKERLDYQHTEKPEELVMHARAILRKKFLEADIGITGCNFAIADTGSVS LVTNEGNGRLVSTLPKTQITVMGMERIVPSFSEFEVLVSMLTRSAVGQRLTSYITALT GPKLEGEVDGPEEFHLVIVDNGRSNILGTEFQSVLQCIRCAACINVCPVYRHVGGHSY GSIYSGPIGAVLSPLLGGYDDYKELPYASSLCAACSEACPVKIPLHELLLKHRQNIVE KEGRAPISEKLAMKAFGLGASSLSLYKMGSKWAPAAMTPFTEDEKISKGPGPLKNWTQ IRDFPAPHKSRFRDWFADRETSERTKEEQ*" /label="lutB CDS" gene complement(3144633..3146072) /gene="lutB" /locus_tag="BSU_34040" /old_locus_tag="BSU34040" /label="lutB gene" promotor_-35 3145620..3145623 /Source="Nicolas_upshift_promotors" /id="U2686" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.967032967032967" /psig="0.001998001998002" /xcortree=71 /SigmaFactorBS="gctctttatttttatgaagagcgggcgctacgatatgtgaCG GCggatcgtgatcatcaatCTGCAaaatatactcgccgagatcggtttctacgacttc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3145640 /Source="Nicolas_upshifts" /id="U2686" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.967032967032967" /psig="0.001998001998002" /xcortree=71 /SigmaFactorBS="gctctttatttttatgaagagcgggcgctacgatatgtgaCG GCggatcgtgatcatcaatCTGCAaaatatactcgccgagatcggtttctacgacttc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3145641..3145645 /Source="Nicolas_upshift_promotors" /id="U2686" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.967032967032967" /psig="0.001998001998002" /xcortree=71 /SigmaFactorBS="gctctttatttttatgaagagcgggcgctacgatatgtgaCG GCggatcgtgatcatcaatCTGCAaaatatactcgccgagatcggtttctacgacttc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 3145794 /Source="Nicolas_upshifts" /id="D1772" /incds=1 /nref=1 /ntot=175 /MaxReadThrough="1.77859" /MaxDrop="3.31917" /score="-7.50175872" /energy="-11.7" /TU="NA" /idTUdmin="U2686" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts 3145948 /Source="Nicolas_upshifts" /id="U2687" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.932067932067932" /psig="0.000999000999001" /xcortree=69 /SigmaFactorBS="acatgctgcctgatttcctctgataatgagcgccactcctcc cagtttcccagttcttctgCTgcctctaggcgccgcgtccgcagacgctcctgtgcac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 3145949..3145950 /Source="Nicolas_upshift_promotors" /id="U2687" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.932067932067932" /psig="0.000999000999001" /xcortree=69 /SigmaFactorBS="acatgctgcctgatttcctctgataatgagcgccactcctcc cagtttcccagttcttctgCTgcctctaggcgccgcgtccgcagacgctcctgtgcac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(3146099..3146815) /gene="lutA" /locus_tag="BSU_34050" /old_locus_tag="BSU34050" /EC_number="1.8.98.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16513748, 19201793, 19508281, 22427629, 24196425, 24274019, 28032445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16513748, 19201793, 19508281, 22427629, 24196425, 24274019, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="iron-sulfur oxidase subunit used in L-lactate utilization" /protein_id="NP_391285.1" /db_xref="EnsemblGenomes-Gn:BSU34050" /db_xref="EnsemblGenomes-Tr:CAB15410" /db_xref="GOA:O07020" /db_xref="InterPro:IPR004017" /db_xref="InterPro:IPR022822" /db_xref="SubtiList:BG12447" /db_xref="UniProtKB/Swiss-Prot:O07020" /translation="MKVSLFVTCLVDMFQTNVGKATVELLERLGCEVDFPEGQICCGQ PAYNSGYVHDAKKAMKRMIETFQDSEYVVSPSGSCTTMFREYPHLFQDDPKWADKAKK LADKTYELTDFIVNVLGVEDVGATLHTKATLHTSCHMTRLLGVRKEPMKLLSHVKGLQ FTELPGKHNCCGFGGTFSVKMAQISEQMVDEKVECVEETGAEVLIGADCGCLMNIGGR LGRKDKNVKVMHIAEVLNSR*" /label="lutA CDS" gene complement(3146099..3146815) /gene="lutA" /locus_tag="BSU_34050" /old_locus_tag="BSU34050" /label="lutA gene" promotor_-35 3146719..3146726 /Source="Nicolas_upshift_promotors" /id="U2688" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.982017982017982" /psig=0 /xcortree=72 /SigmaFactorBS="ccggctgtccgcagcaaatctgcccttctggaaaatcaaCCT CGCACccaagccgctccaGCAgctcaaccgttgcttttccgacatttgtttgaaacat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3146740..3146742 /Source="Nicolas_upshift_promotors" /id="U2688" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.982017982017982" /psig=0 /xcortree=72 /SigmaFactorBS="ccggctgtccgcagcaaatctgcccttctggaaaatcaaCCT CGCACccaagccgctccaGCAgctcaaccgttgcttttccgacatttgtttgaaacat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3146740 /Source="Nicolas_upshifts" /id="U2688" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.982017982017982" /psig=0 /xcortree=72 /SigmaFactorBS="ccggctgtccgcagcaaatctgcccttctggaaaatcaaCCT CGCACccaagccgctccaGCAgctcaaccgttgcttttccgacatttgtttgaaacat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 3146813 /Source="Nicolas_upshifts" /id="D1773" /incds=0 /nref=15 /ntot=169 /MaxReadThrough="1.96527" /MaxDrop="4.662" /score="-7.50175872" /energy="-11.7" /TU="NA" /idTUdmin="U2688" /TUdmin="-15" /isTUend="TRUE" /label="downshifts" S_feature complement(3146816..3146882) /Source="Nicolas_S_feature" /locus_tag="new_3495702_3495768_c" /HighExp="C90, M40t90, T3.0H, T4.0H, HiOs, T1.0H, T3.30H, T2.30H, Lbstat, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.994" /TUlongSig="SigA" /TUlongPSig=1 /label="S1306" promotor_-10 complement(3146879..3146898) /Source="Nicolas_upshift_promotors" /id="U2689" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.754245754245754" /psig="0.994005994005994" /xcortree=3211 /SigmaFactorBS="aaatgaaaatatccctagaaaaCTCTTTCCttccattgtcag aaTAGTGTACGATATTCATATAgttattttaactcaggtcatcagatgacctgatcat a" /listShort="S1306, yvfV, yvfW, yvbY, yvbX, S1305, NA" /listLong="yvbW" /label="promotor_-10" upshifts complement(3146882) /Source="Nicolas_upshifts" /id="U2689" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.754245754245754" /psig="0.994005994005994" /xcortree=3211 /SigmaFactorBS="aaatgaaaatatccctagaaaaCTCTTTCCttccattgtcag aaTAGTGTACGATATTCATATAgttattttaactcaggtcatcagatgacctgatcat a" /listShort="S1306, yvfV, yvfW, yvbY, yvbX, S1305, NA" /listLong="yvbW" /label="upshifts" promotor_-35 complement(3146913..3146920) /Source="Nicolas_upshift_promotors" /id="U2689" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.754245754245754" /psig="0.994005994005994" /xcortree=3211 /SigmaFactorBS="aaatgaaaatatccctagaaaaCTCTTTCCttccattgtcag aaTAGTGTACGATATTCATATAgttattttaactcaggtcatcagatgacctgatcat a" /listShort="S1306, yvfV, yvfW, yvbY, yvbX, S1305, NA" /listLong="yvbW" /label="promotor_-35" CDS complement(3146990..3147592) /gene="yvfU" /locus_tag="BSU_34060" /old_locus_tag="BSU34060" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 18925929, 23504016" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 18925929, 23504016; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YvfT]" /protein_id="NP_391286.1" /db_xref="EnsemblGenomes-Gn:BSU34060" /db_xref="EnsemblGenomes-Tr:CAB15411" /db_xref="GOA:O07019" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12446" /db_xref="UniProtKB/Swiss-Prot:O07019" /translation="MIRLFIAEDQRMLLGALGSLLDLEEDMTVIGQALNGEEALHAIL KLEPDVCIMDIEMPVRSGLNVAEELMKKGCVSKVIILTTFARPGYFERAVKAGAHGYL LKDGEIDDLADAIRKCVKGKRVFSPELTFNMMRDENPLTVREQEILRLAALGKTTKDI TLELYLSQGTVRNYISEIIQKLNAKNRTEAASIAEEKGWI*" /label="yvfU CDS" gene complement(3146990..3147592) /gene="yvfU" /locus_tag="BSU_34060" /old_locus_tag="BSU34060" /label="yvfU gene" CDS complement(3147609..3148724) /gene="yvfT" /locus_tag="BSU_34070" /old_locus_tag="BSU34070" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295, 18925929, 23504016" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 18925929, 23504016; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YvfU]" /protein_id="NP_391287.2" /db_xref="EnsemblGenomes-Gn:BSU34070" /db_xref="EnsemblGenomes-Tr:CAB15412" /db_xref="GOA:Q795K2" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12445" /db_xref="UniProtKB/Swiss-Prot:Q795K2" /translation="MKKAISIFPKEFGFFPYIFLVYTIMPFLSLLKESGVKQGIGYGM LLLFVAAYRQLFCSVGKASFTYWLIVQMAVILMYSVFYNITYIYLGFFPANFVGYYKE KTNFNRAFCALIFILLFPCLYQFIANSVSLRELFSVLPFLVIMLISPFGIRSMFRRIE LEAKLAQANEQIKELSKREERVRIARDLHDTLGHTLSLLTLKSQLIQRLAASDPERTK LEAKEMETSSRSALKQVRELVSDMRTVTITEELVNIQHILRAGNITFQYEGADDFSVI SPVTQNIISMCMREAVTNIIKHSKATHCAITISQFADKMRIVIRDDGKGAPKEKMFGN GLWGMEERLMLIEGGLTVSDHNGTVVALTIPLIKKAE*" /label="yvfT CDS" gene complement(3147609..3148724) /gene="yvfT" /locus_tag="BSU_34070" /old_locus_tag="BSU34070" /label="yvfT gene" CDS complement(3148728..3149465) /gene="yvfS" /locus_tag="BSU_34080" /old_locus_tag="BSU34080" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11717295, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (permease)" /protein_id="NP_391288.1" /db_xref="EnsemblGenomes-Gn:BSU34080" /db_xref="EnsemblGenomes-Tr:CAB15413" /db_xref="GOA:O07017" /db_xref="InterPro:IPR000412" /db_xref="SubtiList:BG12444" /db_xref="UniProtKB/Swiss-Prot:O07017" /translation="MNVLQKQSIAEMKRVLRNKYFVLWSLIMPIAFYYFFTNVVNTNV PDQRAWEAHYLMSMTVFSVMGSSIMTLGIRMVQERSQGWAAFIRLTPLPDHIYLSAQM IGQSVIHVLSITVIFLFGAIINDIALSPFEWMMSGLWILFGALPFLALGTLIGLMRKV ETAAGISNVLYMLLALGGGMWMPFEVMPDMMQSIGQWLPSYHFGSGAWELVRGGSPTW KNILILIAYMMLFMLLSKYIRRKQEAV*" /label="yvfS CDS" gene complement(3148728..3149465) /gene="yvfS" /locus_tag="BSU_34080" /old_locus_tag="BSU34080" /label="yvfS gene" promotor_-10 complement(3148754..3148773) /Source="Nicolas_upshift_promotors" /id="U2690" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.978021978021978" /psig=1 /xcortree=3117 /SigmaFactorBS="gtgggagtccgacttggaaaaatattctgatattaaTCGCTT ATatgatgctcttCATGCTACTATCTAAATATAtaagaagaaaacaagaagcggtgta a" /listShort="yvfT, yvfU" /listLong="S1306, yvfV, yvfW, yvbY, yvbX, S1305, NA" /label="promotor_-10" upshifts complement(3148768) /Source="Nicolas_upshifts" /id="U2690" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.978021978021978" /psig=1 /xcortree=3117 /SigmaFactorBS="gtgggagtccgacttggaaaaatattctgatattaaTCGCTT ATatgatgctcttCATGCTACTATCTAAATATAtaagaagaaaacaagaagcggtgta a" /listShort="yvfT, yvfU" /listLong="S1306, yvfV, yvfW, yvbY, yvbX, S1305, NA" /label="upshifts" promotor_-35 complement(3148785..3148792) /Source="Nicolas_upshift_promotors" /id="U2690" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.978021978021978" /psig=1 /xcortree=3117 /SigmaFactorBS="gtgggagtccgacttggaaaaatattctgatattaaTCGCTT ATatgatgctcttCATGCTACTATCTAAATATAtaagaagaaaacaagaagcggtgta a" /listShort="yvfT, yvfU" /listLong="S1306, yvfV, yvfW, yvbY, yvbX, S1305, NA" /label="promotor_-35" CDS complement(3149466..3150371) /gene="yvfR" /locus_tag="BSU_34090" /old_locus_tag="BSU34090" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11717295; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC efflux transporter (ATP-binding protein)" /protein_id="NP_391289.1" /db_xref="EnsemblGenomes-Gn:BSU34090" /db_xref="EnsemblGenomes-Tr:CAB15414" /db_xref="GOA:O07016" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12443" /db_xref="UniProtKB/Swiss-Prot:O07016" /translation="MMKEAVTVSNVTKHFQRKTAVNNISFSIEKGEIAAILGPNGAGK TTVVSMILGLLKPSEGEIKLFNRVPDDQQVREKIGVMLQEVSVMPGLKVDEILELFRS YYPNPLSMKELVSLTALTKEDLKTRAEKLSGGQKRRLSFALALAGNPELLILDEPTVG MDTSSRHRFWQTIHGLSDQGKTIIFSTHYLQEADDAAQRILFFTEGQLVADGSPMQIR SRIQKQSVSFTLHSSESLERLSCHPEVERVIHEHERTIIQTSNTDKVLALIFQENIHA RDIRIEQATLDEAFRQLADGNREAM*" /label="yvfR CDS" gene complement(3149466..3150371) /gene="yvfR" /locus_tag="BSU_34090" /old_locus_tag="BSU34090" /label="yvfR gene" promotor_-10 complement(3150391..3150409) /Source="Nicolas_upshift_promotors" /id="U2691" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.395604395604396" /psig="0.892107892107892" /xcortree=312 /SigmaFactorBS="gacatttgtcactccatcatcatgacaccccataCTAAcatc gtcttctccgtCATTTTACAATCAATGTAAacgatcaggaggtgctcatgtgatgaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3150402) /Source="Nicolas_upshifts" /id="U2691" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.395604395604396" /psig="0.892107892107892" /xcortree=312 /SigmaFactorBS="gacatttgtcactccatcatcatgacaccccataCTAAcatc gtcttctccgtCATTTTACAATCAATGTAAacgatcaggaggtgctcatgtgatgaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3150425..3150428) /Source="Nicolas_upshift_promotors" /id="U2691" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.395604395604396" /psig="0.892107892107892" /xcortree=312 /SigmaFactorBS="gacatttgtcactccatcatcatgacaccccataCTAAcatc gtcttctccgtCATTTTACAATCAATGTAAacgatcaggaggtgctcatgtgatgaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3150580..3150587 /Source="Nicolas_upshift_promotors" /id="U2692" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=2247 /SigmaFactorBS="ttcttttaaactgctgtgacattcatagaaagataCACTCTT CaaaccatccgAGTGTTATGATAGAAATATTgaactttatattactttccggctgaaa g" /listShort="rsbQ, rsbP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3150598..3150617 /Source="Nicolas_upshift_promotors" /id="U2692" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=2247 /SigmaFactorBS="ttcttttaaactgctgtgacattcatagaaagataCACTCTT CaaaccatccgAGTGTTATGATAGAAATATTgaactttatattactttccggctgaaa g" /listShort="rsbQ, rsbP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3150605 /Source="Nicolas_upshifts" /id="U2692" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=2247 /SigmaFactorBS="ttcttttaaactgctgtgacattcatagaaagataCACTCTT CaaaccatccgAGTGTTATGATAGAAATATTgaactttatattactttccggctgaaa g" /listShort="rsbQ, rsbP" /GFF_Attribute="listLong" /label="upshifts" CDS 3150655..3151464 /gene="rsbQ" /locus_tag="BSU_34100" /old_locus_tag="BSU34100" /function="16.3: Control" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11591687, 12620626, 15632289, 21980452" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11591687, 12620626, 15632289, 21980452; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of RsbP phosphatase" /protein_id="NP_391290.1" /db_xref="EnsemblGenomes-Gn:BSU34100" /db_xref="EnsemblGenomes-Tr:CAB15415" /db_xref="InterPro:IPR000073" /db_xref="InterPro:IPR029058" /db_xref="InterPro:IPR031143" /db_xref="PDB:1WOM" /db_xref="PDB:1WPR" /db_xref="SubtiList:BG12442" /db_xref="UniProtKB/Swiss-Prot:O07015" /translation="MNEAILSRNHVKVKGSGKASIMFAPGFGCDQSVWNAVAPAFEED HRVILFDYVGSGHSDLRAYDLNRYQTLDGYAQDVLDVCEALDLKETVFVGHSVGALIG MLASIRRPELFSHLVMVGPSPCYLNDPPEYYGGFEEEQLLGLLEMMEKNYIGWATVFA ATVLNQPDRPEIKEELESRFCSTDPVIARQFAKAAFFSDHREDLSKVTVPSLILQCAD DIIAPATVGKYMHQHLPYSSLKQMEARGHCPHMSHPDETIQLIGDYLKAHV*" /label="rsbQ CDS" gene 3150655..3151464 /gene="rsbQ" /locus_tag="BSU_34100" /old_locus_tag="BSU34100" /label="rsbQ gene" CDS 3151500..3152711 /gene="rsbP" /locus_tag="BSU_34110" /old_locus_tag="BSU34110" /EC_number="3.1.3.3" /function="16.8: Protect" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10632888, 11591687, 15342585, 15632289, 16267279, 19948797, 21980452, 23524614" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10632888, 11591687, 15342585, 15632289, 16267279, 19948797, 21980452, 23524614; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoserine protein-phosphatase" /protein_id="NP_391291.1" /db_xref="EnsemblGenomes-Gn:BSU34110" /db_xref="EnsemblGenomes-Tr:CAB15416" /db_xref="GOA:O07014" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR001932" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036457" /db_xref="SubtiList:BG12441" /db_xref="UniProtKB/Swiss-Prot:O07014" /translation="MDKQLNDAPCGFLALSEEGSIIAANRTLIKILDYEPEQVIGQHM NMMLTIPAQLFCQLYFFPLLKLEHHIEEIYISLKARDGEEIPVLINAIARHDSGASVF DCVLIPMRKRNEYENELLIARNEAQEALLAKQKANAELEIALETLKAKQEELLEINKQ NQQFKLNTKRELELARKIQKNSLTEPIVNDQVQIDSYYNASSELSGDLYGYYQIDEHR YGIIILDVMGHGISSALITMSLHPLFQRQITQGLSPVKVMKELDRHLHSLFQNDEEAR HYCTAIYLEIDIARQRIDYVNAGHPPALWQDDSGTQHLLHATSPPIGMFEDLEFQSSS LSYTEDGRLLLYTDGVMDPTASCYLFDLLKDHPDSPIADLKEKILTSLQHQKEAHHKS DDECFILVDVK*" /label="rsbP CDS" gene 3151500..3152711 /gene="rsbP" /locus_tag="BSU_34110" /old_locus_tag="BSU34110" /label="rsbP gene" downshifts 3152698 /Source="Nicolas_upshifts" /id="D1774" /incds=0 /nref=181 /ntot=246 /MaxReadThrough="0.90827" /MaxDrop="5.41923" /score="26.3528321" /energy="-17.8" /TU="NA" /idTUdmin="U2692" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS complement(3152765..3154054) /gene="ganB" /locus_tag="BSU_34120" /old_locus_tag="BSU34120" /EC_number="3.2.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:11682178, 17056685, 27501980" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11682178, 17056685, 27501980; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endo-beta-1,4-galactanase" /protein_id="NP_391292.2" /db_xref="EnsemblGenomes-Gn:BSU34120" /db_xref="EnsemblGenomes-Tr:CAB15417" /db_xref="GOA:O07013" /db_xref="InterPro:IPR011683" /db_xref="InterPro:IPR017853" /db_xref="SubtiList:BG12440" /db_xref="UniProtKB/Swiss-Prot:O07013" /translation="MKSKVKMFFAAAIVWSACSSTGYAAAIEKEKHVSELRAEDLFVK KVEGMNKDFIKGADVSSVIALENSGVTFYNTNGKRQDIFTTLKQAGVNYVRVRIWNHP YDSNGNGYGGGNNDVQKAIEIGKRATANGMKVLADFHYSDFWADPAKQKVPKAWANLS FEAKKAKLYEYTKQSLQKMIKEGVDIGMVQVGNETTGGFAGETDWTKMCQLFNEGSRA VRETNSNILVALHFTNPETAGRYSFIAETLSKNKVDYDVFASSYYPFWHGTLQNLTSV LKAVANTYGKKVMVAETSYTYTAEDGDGHGNTAPKSGQTLPYPISVQGQATAVRDVME AVANTGKAGLGVFYWEPAWIPVGPKTQIEKNKVLWETYGSGWASSYAAEYDPEDAGKW YGGSAVDNQALFDFNGHPLPSLQVFQYAESGHIPKKR*" /label="ganB CDS" gene complement(3152765..3154054) /gene="ganB" /locus_tag="BSU_34120" /old_locus_tag="BSU34120" /label="ganB gene" CDS complement(3154134..3156197) /gene="ganA" /locus_tag="BSU_34130" /old_locus_tag="BSU34130" /EC_number="3.2.1.23" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:2104611, 9287030, 17056685, 27501980" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2104611, 9287030, 17056685, 27501980; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="short chain beta-1,4-galacto-oligosaccharides beta-galactosidase (beta-galacto-pyranoside hydrolase)" /protein_id="NP_391293.1" /db_xref="EnsemblGenomes-Gn:BSU34130" /db_xref="EnsemblGenomes-Tr:CAB15418" /db_xref="GOA:O07012" /db_xref="InterPro:IPR003476" /db_xref="InterPro:IPR013529" /db_xref="InterPro:IPR013738" /db_xref="InterPro:IPR013739" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG12439" /db_xref="UniProtKB/Swiss-Prot:O07012" /translation="MMSKLEKTHVTKAKFMLHGGDYNPDQWLDRPDILADDIKLMKLS HTNTFSVGIFAWSALEPEEGVYQFEWLDDIFERIHSIGGRVILATPSGARPAWLSQTY PEVLRVNASRVKQLHGGRHNHCLTSKVYREKTRHINRLLAERYGHHPALLMWHISNEY GGDCHCDLCQHAFREWLKSKYDNSLKTLNHAWWTPFWSHTFNDWSQIESPSPIGENGL HGLNLDWRRFVTDQTISFYENEIIPLKELTPDIPITTNFMADTPDLIPYQGLDYSKFA KHVDAISWDAYPVWHNDWESTADLAMKVGFINDLYRSLKQQPFLLMECTPSAVNWHNV NKAKRPGMNLLSSMQMIAHGSDSVLYFQYRKSRGSSEKLHGAVVDHDNSPKNRVFQEV AKVGETLERLSEVVGTKRPAQTAILYDWENHWALEDAQGFAKATKRYPQTLQQHYRTF WEHDIPVDVITKEQDFSPYKLLIVPMLYLISEDTVSRLKAFTADGGTLVMTYISGVVN EHDLTYTGGWHPDLQAIFGVEPLETDTLYPKDRNAVSYRSQIYEMKDYATVIDVKTAS VEAVYQEDFYARTPAVTSHEYQQGKAYFIGARLEDQFQRDFYEGLITDLSLSPVFPVR HGKGVSVQARQDQDNDYIFVMNFTEEKQLVTFDQSVKDIMTGDILSGDLTMEKYEVRI VVNTH*" /label="ganA CDS" gene complement(3154134..3156197) /gene="ganA" /locus_tag="BSU_34130" /old_locus_tag="BSU34130" /label="ganA gene" CDS complement(3156216..3157067) /gene="ganQ" /locus_tag="BSU_34140" /old_locus_tag="BSU34140" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 17056685, 27501980" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 17056685, 27501980; Product type t: transporter" /codon_start=1 /transl_table=11 /product="galacto-oligosaccharides (galactan) oligomer permease" /protein_id="NP_391294.1" /db_xref="EnsemblGenomes-Gn:BSU34140" /db_xref="EnsemblGenomes-Tr:CAB15419" /db_xref="GOA:O07011" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12438" /db_xref="UniProtKB/Swiss-Prot:O07011" /translation="MLADMKVRRYIRLLFSYLLLAFMAVIIVYPLLWTAGASFNPGNS LISTSIIPKHPTFDHYKELFAGKESLQYVQWYVNSMKISLFTMAGSLLCVTFTAYAFS RFRFKGRKYALTLFLLLQMIPQFSALIALFVLAQILGMINSHWLLILLYIGGLIPMNT YLMKGYMDSIPMDLDESAKIDGASSTRIFFQIILPLSKPMAAVVAMNGFTGPLGDFVL SSTILRTPESYTLPVGLFNLVNDVMGASYTTFAAGALLISIPVAVIFIMLQKNFVSGL TAGGTKG*" /label="ganQ CDS" gene complement(3156216..3157067) /gene="ganQ" /locus_tag="BSU_34140" /old_locus_tag="BSU34140" /label="ganQ gene" CDS complement(3157071..3158327) /gene="ganP" /locus_tag="BSU_34150" /old_locus_tag="BSU34150" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11160890, 15849754, 16850406, 17056685, 27501980" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11160890, 15849754, 16850406, 17056685, 27501980; Product type t : transporter" /codon_start=1 /transl_table=11 /product="galacto-oligosaccharides (galactan) oligomer permease" /protein_id="NP_391295.1" /db_xref="EnsemblGenomes-Gn:BSU34150" /db_xref="EnsemblGenomes-Tr:CAB15420" /db_xref="GOA:O32261" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035277" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12437" /db_xref="UniProtKB/Swiss-Prot:O32261" /translation="MQHRQVALLLSIIPGLGQFYNKQWIKGIVFLFLGASFFAVFGDL LNMGFWGIFTLGTEVPRDNSVFLLAEGIIAVIVTCFGLAVYYVNLRDAFQSGKQRDEN KPLSSLKEQYQHIISEGYPYVVSGPSLFILIFAVIFPILFSFALAFTNYDLYHSPPAK LIDWVGFQTFANIFTVDIWRSTFFDVLAWTVVWTLAASTLQVTLGIFLAIIVNQKDLR FKRFFRTILILPWAVPGFVTILIFAGLFNDSFGAMNHDILAFFGIDPLPWMTDANWSR LALILMQGWLGFPYIFLVSTGVLQSIPDDLYEAATIDGASVFSKLRYITLPMVFIAMA PIIITQFTFNFNNFNIIYLFNGGGPAVTGSTAGGTDILVSWIYKLTMQSSQYSLAAAL TILLSVFVISIALWQFRQTKSFKEEA*" /label="ganP CDS" gene complement(3157071..3158327) /gene="ganP" /locus_tag="BSU_34150" /old_locus_tag="BSU34150" /label="ganP gene" CDS complement(3158367..3159632) /gene="ganS" /locus_tag="BSU_34160" /old_locus_tag="BSU34160" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11682178, 27501980" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11682178, 27501980; Product type t: transporter" /codon_start=1 /transl_table=11 /product="polygalactose / cyclodextrin-binding lipoprotein" /protein_id="NP_391296.1" /db_xref="EnsemblGenomes-Gn:BSU34160" /db_xref="EnsemblGenomes-Tr:CAB15421" /db_xref="GOA:O07009" /db_xref="InterPro:IPR006060" /db_xref="SubtiList:BG12436" /db_xref="UniProtKB/Swiss-Prot:O07009" /translation="MKMAKKCSVFMLCAAVSLSLAACGPKESSSAKSSSKGSELVVWE DKEKSNGIKDAVAAFEKEHDVKVKVVEKPYAKQIEDLRMDGPAGTGPDVLTMPGDQIG TAVTEGLLKELHVKKDVQSLYTDASIQSQMVDQKLYGLPKAVETTVLFYNKDLITEKE LPKTLEEWYDYSKKTADGSKFGFLALFDQIYYAESVMSGYGGYIFGKAKDGSYNPSDI GINNEGAVKGAALIQKFYKDGLFPAGIIGEQGINVLESLFTEGKAAAIISGPWNVEAF SNAGINYGITKLPKLENGKNMSSFIGVKSYNVSAFSKNEELAQELAVFLANEKNSKTR YEETKEVPAVKSLANDPAIMKSEAARAVTEQSRFSEPTPNIPEMNEIWTPADSALQTV ATGKADPKQALDQAAETAKGQIKAKHSGK*" /label="ganS CDS" gene complement(3158367..3159632) /gene="ganS" /locus_tag="BSU_34160" /old_locus_tag="BSU34160" /label="ganS gene" promotor_-10 complement(3159664..3159683) /Source="Nicolas_upshift_promotors" /id="U2693" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.968031968031968" /psig=1 /xcortree=325 /SigmaFactorBS="tttatttaggtaaaaaaatttactctatgaagtaaatagttT GTTTACAcattttctcaggcaTGCTATATTATCTTTAAAGCgctttcattcctaccga a" /listShort="cycB, ganP, ganQ, ganA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3159686) /Source="Nicolas_upshifts" /id="U2693" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.968031968031968" /psig=1 /xcortree=325 /SigmaFactorBS="tttatttaggtaaaaaaatttactctatgaagtaaatagttT GTTTACAcattttctcaggcaTGCTATATTATCTTTAAAGCgctttcattcctaccga a" /listShort="cycB, ganP, ganQ, ganA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3159698..3159705) /Source="Nicolas_upshift_promotors" /id="U2693" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.968031968031968" /psig=1 /xcortree=325 /SigmaFactorBS="tttatttaggtaaaaaaatttactctatgaagtaaatagttT GTTTACAcattttctcaggcaTGCTATATTATCTTTAAAGCgctttcattcctaccga a" /listShort="cycB, ganP, ganQ, ganA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3159773..3160765) /gene="ganR" /locus_tag="BSU_34170" /old_locus_tag="BSU34170" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:2104611, 9287030, 10486575, 17056685, 27501980, 28617843" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2104611, 9287030, 10486575, 17056685, 27501980, 28617843; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of the galactan degradation operon (GanR / beta-1,4-galactobiose)" /protein_id="NP_391297.1" /db_xref="EnsemblGenomes-Gn:BSU34170" /db_xref="EnsemblGenomes-Tr:CAB15422" /db_xref="GOA:O07008" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG12435" /db_xref="UniProtKB/Swiss-Prot:O07008" /translation="MATIKDIAQEAGFSISTVSRVLNNDESLSVPDETREKIYEAAEK LNYRKKTVRPLVKHIAFLYWLTDKEELEDVYFKTMRLEVEKLAKAFNVDMTTYKIADG IESIPEHTEGFIAVGTFSDEELAFLRNLTENGVFIDSTPDPDHFDSVRPDLAQMTRKT VNILTEKGHKSIGFIGGTYKNPNTNQDEMDIREQTFRSYMREKAMLDERYIFCHRGFS VENGYRLMSAAIDTLGDQLPTAFMIAADPIAVGCLQALNEKGIAIPNRVSIVSINNIS FAKYVSPPLTTFHIDIHELCKNAVQLLLEQVQDKRRTVKTLYVGAELIVRKSMN*" /label="ganR CDS" gene complement(3159773..3160765) /gene="ganR" /locus_tag="BSU_34170" /old_locus_tag="BSU34170" /label="ganR gene" downshifts complement(3159807) /Source="Nicolas_upshifts" /id="D1775" /incds=0 /nref=2 /ntot=55 /MaxReadThrough="1.40325" /MaxDrop="2.80992" /score="14.7399792" /energy="-8.3" /TU="NA" /idTUdmin="U2694" /TUdmin=1111 /isTUend="FALSE" /label="downshifts" S_feature complement(3160895..3160944) /Source="Nicolas_S_feature" /locus_tag="new_3509781_3509830_c" /HighExp="Sw, BC, M0t90, M40t90, B60, Lbstat, Lbtran, S2, B36, nit" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.29208099999999998" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1307" downshifts complement(3160918) /Source="Nicolas_upshifts" /id="D1776" /incds=0 /nref=88 /ntot=240 /MaxReadThrough="1.88481" /MaxDrop="5.0699" /score="7.28170345" /energy="-13.7" /TU="NA" /idTUdmin="U2694" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3160945..3161604) /gene="lutR" /locus_tag="BSU_34180" /old_locus_tag="BSU34180" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:18604637, 24196425, 25031425" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18604637, 24196425, 25031425; Product type r: regulator" /codon_start=1 /transl_table=11 /product="L-lactate utilization global transcriptional regulator (GntR family)" /protein_id="NP_391298.2" /db_xref="EnsemblGenomes-Gn:BSU34180" /db_xref="EnsemblGenomes-Tr:CAB15423" /db_xref="GOA:O07007" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR008920" /db_xref="InterPro:IPR011711" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12434" /db_xref="UniProtKB/Swiss-Prot:O07007" /translation="MIKNGELKPGDKLDSVQALAESFQVSRSAVREALSALKAMGLVE MKQGEGTYLKEFELNQISQPLSAALLMKKEDVKQLLEVRKLLEIGVASLAAEKRTEAD LERIQDALKEMGSIEADGELGEKADFAFHLALADASQNELLKHLMNHVSSLLLETMRE TRKIWLFSKKTSVQRLYEEHERIYNAVAAGNGAQAEAAMLAHLTNVEDVLSGYFEENV Q*" /label="lutR CDS" gene complement(3160945..3161604) /gene="lutR" /locus_tag="BSU_34180" /old_locus_tag="BSU34180" /label="lutR gene" S_feature complement(3161605..3161710) /Source="Nicolas_S_feature" /locus_tag="new_3510491_3510596_c" /HighExp="M0t90, Lbstat, BC, M40t90, Lbtran, Sw, S2, B60, ferm, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.69672000000000001" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1308" promotor_-10 complement(3161702..3161721) /Source="Nicolas_upshift_promotors" /id="U2694" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.967032967032967" /psig="0.999000999001" /xcortree=1596 /SigmaFactorBS="agtacaagactttttgacaaaatagtcaaaatCTTTtggcgg cccacaaaACAGAGTATAATAGATCGTAaacagccagacctacaagttacggggtgaa t" /listShort="S1308, yvfI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3161711) /Source="Nicolas_upshifts" /id="U2694" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.967032967032967" /psig="0.999000999001" /xcortree=1596 /SigmaFactorBS="agtacaagactttttgacaaaatagtcaaaatCTTTtggcgg cccacaaaACAGAGTATAATAGATCGTAaacagccagacctacaagttacggggtgaa t" /listShort="S1308, yvfI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3161736..3161739) /Source="Nicolas_upshift_promotors" /id="U2694" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.967032967032967" /psig="0.999000999001" /xcortree=1596 /SigmaFactorBS="agtacaagactttttgacaaaatagtcaaaatCTTTtggcgg cccacaaaACAGAGTATAATAGATCGTAaacagccagacctacaagttacggggtgaa t" /listShort="S1308, yvfI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3161763..3161770 /Source="Nicolas_upshift_promotors" /id="U2695" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.516483516483517" /psig=1 /xcortree=494 /SigmaFactorBS="gtgggccgccaaaagattttgactattttgtcaaaaagTCTT GTACtttgatttttttcaAAATATAATGCTAGGTAACTggtcttattacccagtcatc a" /listShort="S1309, yvfH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3161785..3161804 /Source="Nicolas_upshift_promotors" /id="U2695" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.516483516483517" /psig=1 /xcortree=494 /SigmaFactorBS="gtgggccgccaaaagattttgactattttgtcaaaaagTCTT GTACtttgatttttttcaAAATATAATGCTAGGTAACTggtcttattacccagtcatc a" /listShort="S1309, yvfH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3161785 /Source="Nicolas_upshifts" /id="U2695" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.516483516483517" /psig=1 /xcortree=494 /SigmaFactorBS="gtgggccgccaaaagattttgactattttgtcaaaaagTCTT GTACtttgatttttttcaAAATATAATGCTAGGTAACTggtcttattacccagtcatc a" /listShort="S1309, yvfH" /GFF_Attribute="listLong" /label="upshifts" S_feature 3161788..3161893 /Source="Nicolas_S_feature" /locus_tag="new_3510674_3510779" /HighExp="T1.30H, S1, T1.0H, M40t90, T2.0H, M0t90, T3.0H, T2.30H, T0.30H, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1309" promotor_-10 complement(3161794..3161811) /Source="Nicolas_upshift_promotors" /id="U2696" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.543456543456543" /psig="0.330669330669331" /xcortree=381 /SigmaFactorBS="atgtaagcggtttctatagatgatatgatcatcTGATGACtg ggtaaTAAGACCAGTTACCTAGCattatattttgaaaaaaatcaaagtacaagacttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3161798) /Source="Nicolas_upshifts" /id="U2696" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.543456543456543" /psig="0.330669330669331" /xcortree=381 /SigmaFactorBS="atgtaagcggtttctatagatgatatgatcatcTGATGACtg ggtaaTAAGACCAGTTACCTAGCattatattttgaaaaaaatcaaagtacaagacttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3161819..3161825) /Source="Nicolas_upshift_promotors" /id="U2696" /multdbtbs="-" /comp="M6" /sig="Sig-" /pcomp="0.543456543456543" /psig="0.330669330669331" /xcortree=381 /SigmaFactorBS="atgtaagcggtttctatagatgatatgatcatcTGATGACtg ggtaaTAAGACCAGTTACCTAGCattatattttgaaaaaaatcaaagtacaagacttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3161894..3163585 /gene="lutP" /locus_tag="BSU_34190" /old_locus_tag="BSU34190" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 25031425; Product type t: transporter" /codon_start=1 /transl_table=11 /product="L-lactate permease" /protein_id="NP_391299.1" /db_xref="EnsemblGenomes-Gn:BSU34190" /db_xref="EnsemblGenomes-Tr:CAB15424" /db_xref="GOA:P71067" /db_xref="InterPro:IPR003804" /db_xref="SubtiList:BG11875" /db_xref="UniProtKB/Swiss-Prot:P71067" /translation="MQWTQAYTPIGGNLLLSALAALVPIIFFFWALAIKRMKGYTAGL ATLGIALIIAVLVYRMPAEKALMSATQGAVYGLLPIGWIIVTSVFLYKITVKTGQFDI IRSSVLSITDDRRLQALLIAFSFGAFLEGAAGFGAPVAISAALLVGLGFNPLYAAGIC LIANTAPVAFGAIGIPITAVEGPTGIPAMEISQMVGRQLPFLSVFIPLYLIIIMSGFR KALEIWPAILVSGVSFAVVQYLSSNFLGPELPDVLSALVSMAALAVFLKWWKPKTTFR FAGEQESAASIETARTNPAAPAYRGGQIFKAWSPFLLLTAMISVWGIPSVKSALTGHY EGSAVFLKWLNAVGEKLTFSPGVPFLNNQIVNADGTPIEAVYKLEVLGSAGTAILIAA VLSKFITAISWKDWGTVFKETVQELKLPILTIASVVGFAYVTNSSGMSTTLGMTLALT GSMFTFFSPVLGWLGVFITGSDTSANLLFGNLQKVTALSVGMDPVLSVAANSSGGVTG KMISPQSIAVACAAVGLAGKESDLFRFTIKHSLFLLLLVCIITFLQHHVFSWMIP*" /label="lutP CDS" gene 3161894..3163585 /gene="lutP" /locus_tag="BSU_34190" /old_locus_tag="BSU34190" /label="lutP gene" downshifts 3163570 /Source="Nicolas_upshifts" /id="D1777" /incds=0 /nref=153 /ntot=245 /MaxReadThrough="4.82757" /MaxDrop="5.44233" /score="20.8815301" /energy="-11.7" /TU="NA" /idTUdmin="U2695" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3163612..3164922) /gene="sigL" /locus_tag="BSU_34200" /old_locus_tag="BSU34200" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11274109, 12533460, 12634342, 16166551, 16585774" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11274109, 12533460, 12634342, 16166551, 16585774; Product type r: regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase sigma-54 factor (sigma-L)" /protein_id="NP_391300.1" /db_xref="EnsemblGenomes-Gn:BSU34200" /db_xref="EnsemblGenomes-Tr:CAB15425" /db_xref="GOA:P24219" /db_xref="InterPro:IPR000394" /db_xref="InterPro:IPR007046" /db_xref="InterPro:IPR007634" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10748" /db_xref="UniProtKB/Swiss-Prot:P24219" /translation="MDMKLQQVQVLKPQLTQELRQAITLLGYHSAELAEYIDELSLEN PLIERKETDTPPLSYHKTNKNRMNAQEAGLQLSNPQKTLQDALKQQSLDMNLTNTEKK IFNYLIHSLDSNGYLEEDIEEAARRLSVSAKEAEAVLAKLQSLEPAGIGARSLQECIL LQLQRLPNRNEQAEMLVSAHFDAFAQKKWKTLSVETGIPLHTIQDISDDIAALHPRPG LLFARPEQDVYIEPDIFITVKNGHIAAELNTRSFPEIDLHPQYRTLLSSGSCQDTVSY LSAKYQEWRWLSRALRQRKQTITRIINELITRQKDFFLKGRSAMKPLTLREVADCLSL HESTVSRAIKGKTIQTPYGLFEMKLFFSAKAEASGDGDASNYAVKTHLENLINQEDKT KPLSDQKLVDLLYEQHGIQISRRTVAKYRDQMNIPSSAARKRYK*" /label="sigL CDS" gene complement(3163612..3164922) /gene="sigL" /locus_tag="BSU_34200" /old_locus_tag="BSU34200" /label="sigL gene" S_feature 3163615..3164685 /Source="Nicolas_S_feature" /locus_tag="new_3512501_3513571" /HighExp="M9-stat, T1.30H, S1, Sw, T1.0H, T2.0H, T0.30H, G/S, T3.30H, T2.30H" /AntisenseName="sigL" /AntisenseCor="0.63927172079726402" /AntisenseRegPval="-31.6" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1310" downshifts complement(3163624) /Source="Nicolas_upshifts" /id="D1778" /incds=0 /nref=62 /ntot=219 /MaxReadThrough="2.33779" /MaxDrop="5.56948" /score="28.2409666" /energy="-11.7" /TU="NA" /idTUdmin="U2698" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature 3164742..3164761 /Source="Nicolas_upshift_promotors" /id="U2697" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.656343656343656" /psig=1 /xcortree=2629 /SigmaFactorBS="tttgcggattacttaattgaaggcccgcttcctgtgcattca tcctgtttttgtttgtttTATGGTAAGATAGTGGCGGTgtgtctgtttcctttcgttc a" /listShort="S1311, yvfG" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 3164742..3165000 /Source="Nicolas_S_feature" /locus_tag="new_3513628_3513886" /HighExp="LBGstat, LBGexp, G180, Paraq, H2O2, LBGtran, Oxctl, Lbexp, dia0, HPh" /AntisenseName="sigL" /AntisenseCor="-0.50245218771496702" /AntisenseRegPval="-17.899999999999999" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1311" upshifts 3164742 /Source="Nicolas_upshifts" /id="U2697" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.656343656343656" /psig=1 /xcortree=2629 /SigmaFactorBS="tttgcggattacttaattgaaggcccgcttcctgtgcattca tcctgtttttgtttgtttTATGGTAAGATAGTGGCGGTgtgtctgtttcctttcgttc a" /listShort="S1311, yvfG" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3164936..3164955) /Source="Nicolas_upshift_promotors" /id="U2698" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.94005994005994" /psig=1 /xcortree=424 /SigmaFactorBS="agttcagacatttctttggcagctcctttttcataaatGTAT acggtgtgatctcaATCATGTACAATGAAGAAAGgggagtgagcaagatggatatgaa a" /listShort="sigL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3164951) /Source="Nicolas_upshifts" /id="U2698" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.94005994005994" /psig=1 /xcortree=424 /SigmaFactorBS="agttcagacatttctttggcagctcctttttcataaatGTAT acggtgtgatctcaATCATGTACAATGAAGAAAGgggagtgagcaagatggatatgaa a" /listShort="sigL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3164970..3164973) /Source="Nicolas_upshift_promotors" /id="U2698" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.94005994005994" /psig=1 /xcortree=424 /SigmaFactorBS="agttcagacatttctttggcagctcctttttcataaatGTAT acggtgtgatctcaATCATGTACAATGAAGAAAGgggagtgagcaagatggatatgaa a" /listShort="sigL" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3165001..3165219 /gene="yvfG" /locus_tag="BSU_34210" /old_locus_tag="BSU34210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391301.1" /db_xref="EnsemblGenomes-Gn:BSU34210" /db_xref="EnsemblGenomes-Tr:CAB15426" /db_xref="InterPro:IPR018590" /db_xref="PDB:2GSV" /db_xref="PDB:2JS1" /db_xref="SubtiList:BG11876" /db_xref="UniProtKB/Swiss-Prot:P71066" /translation="MSELFSVPYFIENLKQHIEMNQSEDKIHAMNSYYRSVVSTLVQD QLTKNAVVLKRIQHLDEAYNKVKRGESK*" /label="yvfG CDS" gene 3165001..3165219 /gene="yvfG" /locus_tag="BSU_34210" /old_locus_tag="BSU34210" /label="yvfG gene" downshifts 3165198 /Source="Nicolas_upshifts" /id="D1779" /incds=0 /nref=53 /ntot=250 /MaxReadThrough="3.27525" /MaxDrop="4.21929" /score="-0.306638574" /energy="-13.4" /TU="U2697" /idTUdmin="U2697" /TUdmin="-418" /isTUend="FALSE" /label="downshifts" CDS complement(3165229..3166197) /gene="epsO" /locus_tag="BSU_34220" /old_locus_tag="BSU34220" /EC_number="2.-.-.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 1097084, 115661000, 20720312, 23378512; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyruvyl transferase for matrix biofilm formation" /protein_id="NP_391302.1" /db_xref="EnsemblGenomes-Gn:BSU34220" /db_xref="EnsemblGenomes-Tr:CAB15427" /db_xref="GOA:P71065" /db_xref="InterPro:IPR007345" /db_xref="SubtiList:BG11874" /db_xref="UniProtKB/Swiss-Prot:P71065" /translation="MDSKHSMISLKQKLSGLLDVIPKQSEIIYADYPLYGNVGDLFIM KGTEAFFKEHGIRVRKRWNPDNFPIGRKLDPNLIIVCQGGGNFGDLYPYYQGFREKIV QTYPNHKIVILPQSIYFQNKDNLKRTAEIFSKHANLHIMTREKASYATAQAYFTTNHI QLLPDMAHQLFPVIPTQQPSNQKLRFIRTDHEANQALQEHAEAESYDWRTVLSASDRR TIAFLQTLNVLNKKAGNPLPIAYIWEKYSDYIVQKAIRFFSRYESVETSRLHGHILSS LLQKENTVIDNSYGKNANYFHTWMEGVPSTRLIQHASKKENLPAHM*" /label="epsO CDS" gene complement(3165229..3166197) /gene="epsO" /locus_tag="BSU_34220" /old_locus_tag="BSU34220" /label="epsO gene" CDS complement(3166176..3167342) /gene="epsN" /locus_tag="BSU_34230" /old_locus_tag="BSU34230" /EC_number="2.6.1.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15661000, 20720312, 23378512, 27084765, 27897378; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aminotransferase involved in biofilm matrix formation" /protein_id="NP_391303.2" /db_xref="EnsemblGenomes-Gn:BSU34230" /db_xref="EnsemblGenomes-Tr:CAB15428" /db_xref="GOA:Q795J3" /db_xref="InterPro:IPR000653" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG11873" /db_xref="UniProtKB/Swiss-Prot:Q795J3" /translation="MHKKIYLSPPHMSGREQHYISEAFRSNWIAPLGPLVNSFEEQLA ERVGVKAAAAVGSGTAAIHLALRLLEVKEGDSVFCQSFTFVATANPILYEKAVPVFID SEPDTWNMSPTALERALEEAKRNGTLPKAVIAVNLYGQSAKMDEIVSLCDAYGVPVIE DAAESLGTVYKGKQSGTFGRFGIFSFNGNKIITTSGGGMLVSNDEAAIEKARFLASQA REPAVHYQHSEIGHNYRLSNILAGVGIAQLEVLDERVEKRRTIFTRYKNALGHLDGVR FMPEYAAGVSNRWLTTLTLDNGLSPYDIVQRLAEENIEARPLWKPLHTQPLFDPALFY SHEDTGSVCEDLFKRGICLPSGSNMTEDEQGRVIEVLLHLFHTVEVKKWTASIR*" /label="epsN CDS" gene complement(3166176..3167342) /gene="epsN" /locus_tag="BSU_34230" /old_locus_tag="BSU34230" /label="epsN gene" CDS complement(3167347..3167997) /gene="epsM" /locus_tag="BSU_34240" /old_locus_tag="BSU34240" /function="16.5: Explore" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15661000, 27897378; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative O-acetyltransferase involved in biofilmmatrix formation" /protein_id="NP_391304.1" /db_xref="EnsemblGenomes-Gn:BSU34240" /db_xref="EnsemblGenomes-Tr:CAB15429" /db_xref="GOA:P71063" /db_xref="InterPro:IPR001451" /db_xref="InterPro:IPR011004" /db_xref="InterPro:IPR018357" /db_xref="InterPro:IPR020019" /db_xref="SubtiList:BG11872" /db_xref="UniProtKB/Swiss-Prot:P71063" /translation="MKNVAIVGDGGHGKVIRELINARSDTRLAAVLDDKFKTFEGGKE WYTGPPKAVTELRRLIPDVLFLIAVGNNSVRKQLAERLGLGKDDFITLIHPSAIVSKS AVIGEGTVIMAGAIIQADARIGAHCIINTGAVAEHDNQISDYVHLSPRATLSGAVSVQ EGAHVGTGASVIPQIIIGAWSIVGAGSAVIRSIPDRVTAAGAPARIISSIQTSNKG*" /label="epsM CDS" gene complement(3167347..3167997) /gene="epsM" /locus_tag="BSU_34240" /old_locus_tag="BSU34240" /label="epsM gene" CDS complement(3167994..3168602) /gene="epsL" /locus_tag="BSU_34250" /old_locus_tag="BSU34250" /EC_number="2.7.-.-" /function="16.5: Explore" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15175311, 15661000, 23378512; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphotransferase involved in extracellular matrix synthesis" /protein_id="NP_391305.1" /db_xref="EnsemblGenomes-Gn:BSU34250" /db_xref="EnsemblGenomes-Tr:CAB15430" /db_xref="GOA:P71062" /db_xref="InterPro:IPR003362" /db_xref="SubtiList:BG11871" /db_xref="UniProtKB/Swiss-Prot:P71062" /translation="MILKRLFDLTAAIFLLCCTSVIILFTIAVVRLKIGSPVFFKQVR PGLHGKPFTLYKFRTMTDERDSKGNLLPDEVRLTKTGRLIRKLSIDELPQLLNVLKGD LSLVGPRPLLMDYLPLYTEKQARRHEVKPGITGWAQINGRNAISWEKKFELDVWYVDN WSFFLDLKILCLTVRKVLVSEGIQQTNHVTAERFTGSGDVSS*" /label="epsL CDS" gene complement(3167994..3168602) /gene="epsL" /locus_tag="BSU_34250" /old_locus_tag="BSU34250" /label="epsL gene" CDS complement(3168599..3170116) /gene="epsK" /locus_tag="BSU_34265" /old_locus_tag="BSU34265" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15175311, 15661000, 15849754, 16850406, 26078454, 27897378; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative extracellular matrix component exporter; putative cyclic di-GMP receptor" /protein_id="YP_003097789.1" /db_xref="EnsemblGenomes-Gn:BSU34265" /db_xref="EnsemblGenomes-Tr:CAX52695" /db_xref="GOA:P71060" /db_xref="InterPro:IPR002797" /db_xref="InterPro:IPR029303" /db_xref="UniProtKB/Swiss-Prot:P71060" /translation="MKFTINFSANLTAFLLSVFLSVWMTPFIVKTLGVEAFGFVHLTQ NVINYFSVITVALSSVVVRFFSVAAHRGEREKANAYISNYLAASVLISLLLLLPLAGS AFFIDRVMNVPQALLADVRLSILIGSVLFILTFLMAGFGAAPFYANRLYITSSIQAVQ MLIRVLSVLLLFACFAPKIWQIQLAALAGAVIASVLSFYFFKKLIPWFSFRMKDLSFR TSKELFQAGAWSSVNQIGVLLFLQIDLLTANLMLGASASGKYAAIIQFPLLLRSLAGT VASLFAPIMTSYYSKGDMEGLMNYANKAVRLNGLLLALPAALLGGLAGPFLTIWLGPS FSTIAPLLFIHAGYLVVSLAFMPLFYIWTAFNQQKTPAIVTLLLGAVNVVLAVTLSGP AHLGLYGITLAGAISLILKNAIFTPLYVSRITGYKKHVFLKGIIGPLSAAVFAWTVCK AIQFIVKIDSWPSLIATGVTVSFCYAVFAFMLVCTKEERQLVLKRFRKTKGAVNL*" /label="epsK CDS" gene complement(3168599..3170116) /gene="epsK" /locus_tag="BSU_34265" /old_locus_tag="BSU34265" /label="epsK gene" CDS complement(3170113..3171147) /gene="epsJ" /locus_tag="BSU_34280" /old_locus_tag="BSU34280" /EC_number="2.4.-.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15661000, 20720312, 26078454, 27897378; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyl transferase involved in biofilm matrix formation" /protein_id="NP_391308.1" /db_xref="EnsemblGenomes-Gn:BSU34280" /db_xref="EnsemblGenomes-Tr:CAB15433" /db_xref="GOA:P71059" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG11868" /db_xref="UniProtKB/Swiss-Prot:P71059" /translation="MIPLVSIIVPMYNVEPFIEECIDSLLRQTLSDIEIILVNDGTPD RSGEIAEDYAKRDARIRVIHQANGGLSSARNTGIKAARGTYIGFVDGDDYVSSAMFQR LTEEAEQNQLDIVGCGFYKQSSDRRTYVPPQLEANRVLTKPEMTEQLKHAHETRFIWY VWRYLYRRELFERANLLFDEDIRFAEDSPFNLSAFREAERVKMLDEGLYIYRENPNSL TEIPYKPAMDEHLQKQYQAKIAFYNHYGLAGACKEDLNVYICRHQLPMLLANACASPN SPKDIKKKIRQILSYDMVRQAVRHTPFQHEKLLRGERLVLALCKWRLTFLIKLFFEQR GTMKGSAKQA*" /label="epsJ CDS" gene complement(3170113..3171147) /gene="epsJ" /locus_tag="BSU_34280" /old_locus_tag="BSU34280" /label="epsJ gene" CDS complement(3171144..3172220) /gene="epsI" /locus_tag="BSU_34290" /old_locus_tag="BSU34290" /EC_number="2.-.-.-" /function="16.8: Protect" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15173185, 15661000, 20720312, 26078454; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative polysaccharide pyruvyl transferase involved in biofilm matrix formation" /protein_id="NP_391309.1" /db_xref="EnsemblGenomes-Gn:BSU34290" /db_xref="EnsemblGenomes-Tr:CAB15434" /db_xref="GOA:P71058" /db_xref="InterPro:IPR007345" /db_xref="SubtiList:BG11867" /db_xref="UniProtKB/Swiss-Prot:P71058" /translation="MSLQSLKINFAEWLLLKVKYPSQYWLGAADQPVKAAAHQKKIIL TLLPSHDNLGDHAIAYASKAFLEQEYPDFDIVEVDMKDIYKSAKSLIRSRHPEDMVFI IGGGNMGDLYRYEEWTRRFIIKTFHDYRVVQLPATAHFSDTKKGRKELKRAQKIYNAH PGLLLMARDETTYQFMKQHFQEKTILKQPDMVLYLDRSKAPAEREGVYMCLREDQESV LQEEQRNRVKAALCEEFGEIKSFTTTIGRRVSRDTREHELEALWSKLQSAEAVVTDRL HGMIFCALTGTPCVVIRSFDHKVMEGYQWLKDIPFMKLIEHPEPERVTAAVNELLTKE TSRAGFPRDVYFKGLRDKISGEAQ*" /label="epsI CDS" gene complement(3171144..3172220) /gene="epsI" /locus_tag="BSU_34290" /old_locus_tag="BSU34290" /label="epsI gene" CDS complement(3172225..3173259) /gene="epsH" /locus_tag="BSU_34300" /old_locus_tag="BSU34300" /EC_number="2.-.-.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15083514, 15661000; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase involved in biofilmformation" /protein_id="NP_391310.1" /db_xref="EnsemblGenomes-Gn:BSU34300" /db_xref="EnsemblGenomes-Tr:CAB15435" /db_xref="GOA:P71057" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG11866" /db_xref="UniProtKB/Swiss-Prot:P71057" /translation="METPAVSLLVAVYNTETYIRTCLESLRNQTMDNIEIIIVNDGSA DASPDIAEEYAKMDNRFKVIHQENQGLGAVRNKGIEAARGEFIAFIDSDDWIEPDYCE QMLRTAGDETDLVICNYAAEFEDTGKTMDSDIAQTYQDQPKEHYIKALFEGKVRGFSW NKLYRRSMIEAHRLSFPLRGELEHVEDQFFSFRAHFFARSVSYVKTPLYHYRIHLSSI VQRYQKKLFESGLALYETNAAFLQENNKLEEYRKELDTFIVLHSSICMLNEWKTSGSR RLFEKLRNVGVICADPVFQESLSKTGTAPFDAKRSCLLLMAKYRMIPFVAMASAVYQR VIEYKMRNRG*" /label="epsH CDS" gene complement(3172225..3173259) /gene="epsH" /locus_tag="BSU_34300" /old_locus_tag="BSU34300" /label="epsH gene" CDS complement(3173284..3174387) /gene="epsG" /locus_tag="BSU_34310" /old_locus_tag="BSU34310" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15175311, 15661000, 15849754, 16850406, 22451411" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15175311, 15661000, 15849754, 16850406, 22451411; Product type f: factor" /codon_start=1 /transl_table=11 /product="biofilm extracellular matrix formation chain-length determining factor" /protein_id="NP_391311.1" /db_xref="EnsemblGenomes-Gn:BSU34310" /db_xref="EnsemblGenomes-Tr:CAB15436" /db_xref="GOA:P71056" /db_xref="SubtiList:BG11865" /db_xref="UniProtKB/Swiss-Prot:P71056" /translation="MIVYAVNMGIVFIWSWFAKMCGGRDDSLATGYRPNKLLIWIPLA SLVLVSGLRYRVGTDFQTYTLLYELAGDYQNVWQIFGFGTAKTATDPGFTALLWLMNF ITEDPQIMYFTVAVVTYSFIMKTLADYGRPFELSVFLFLGTFHYYASFNGIRQYMVAA VLFWAIRYIISGNWKRYFLIVLVSSLFHSSALIMIPVYFIVRRKAWSPAIFGLSALFL GMTFLYQKFISVFVVVLENSSYSHYEKWLMTNTNGMNVIKIAVLVLPLFLAFCYKERL RSLWPQIDIVVNLCLLGFLFGLLATKDVIFARFNIYFGLYQMILVPYFVRIFDEKSNA LIYIAIVVCYFLYSYLLMPVDSSVLPYRTIFSR*" /label="epsG CDS" gene complement(3173284..3174387) /gene="epsG" /locus_tag="BSU_34310" /old_locus_tag="BSU34310" /label="epsG gene" CDS complement(3174384..3175538) /gene="epsF" /locus_tag="BSU_34320" /old_locus_tag="BSU34320" /EC_number="2.-.-.-" /function="16.5: Explore" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15175311, 15661000, 22451411; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase involved in matrix formation (chain-length determination)" /protein_id="NP_391312.1" /db_xref="EnsemblGenomes-Gn:BSU34320" /db_xref="EnsemblGenomes-Tr:CAB15437" /db_xref="GOA:P71055" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR028098" /db_xref="SubtiList:BG11864" /db_xref="UniProtKB/Swiss-Prot:P71055" /translation="MNSSQKRVLHVLSGMNRGGAETMVMNLYRKMDKSKVQFDFLTYR NDPCAYDEEILSLGGRLFYVPSIGQSNPLTFVRNVRNAIKENGPFSAVHAHTDFQTGF IALAARLAGVPVRVCHSHNTSWKTGFNWKDRLQLLVFRRLILANATALCACGEDAGRF LFGQSNMERERVHLLPNGIDLELFAPNGQAADEEKAARGIAADRLIIGHVARFHEVKN HAFLLKLAAHLKERGIRFQLVLAGDGPLCGEIEEEARQQNLLSDVLFLGTEERIHELM RTFDVFVMPSLYEGLPVVLVEAQASGLPCIISDSITEKVDAGLGLVTRLSLSEPISVW AETIARAAAAGRPKREFIKETLAQLGYDAQQNVGALLNVYNISTEKDHNR*" /label="epsF CDS" gene complement(3174384..3175538) /gene="epsF" /locus_tag="BSU_34320" /old_locus_tag="BSU34320" /label="epsF gene" CDS complement(3175531..3176367) /gene="epsE" /locus_tag="BSU_34330" /old_locus_tag="BSU34330" /EC_number="2.-.-.-" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15175311, 15661000, 21170308, 22720735, 23480406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15175311, 15661000, 21170308, 22720735, 23480406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional flagellar clutch and glycosyltransferase acting during biofilm formation" /protein_id="NP_391313.2" /db_xref="EnsemblGenomes-Gn:BSU34330" /db_xref="EnsemblGenomes-Tr:CAB15438" /db_xref="GOA:P71054" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG11863" /db_xref="UniProtKB/Swiss-Prot:P71054" /translation="MNSGPKVSVIMGIYNCERTLAESIESILSQSYKNWELILCDDAS TDGTLRIAKQYAAHYSDRIKLIQNKTNKRLAASLNHCLSHATGDYIARQDGDDLSFPR RLEKQVAFLEKHRHYQVVGTGMLVFDEFGVRGARILPSVPEPGIMAKGTPFCHGTIMM RASAYRTLKGYRSVRRTRRMEDIDLWLRFFEEGFRGYNLQEALYKVREDSDAFKRRSF TYSIDNAILVYQACRRLKLPLSDYIYIAKPLIRAFMPAAVMNRYHKKRVMNQKEGLVK HE*" /label="epsE CDS" gene complement(3175531..3176367) /gene="epsE" /locus_tag="BSU_34330" /old_locus_tag="BSU34330" /label="epsE gene" CDS complement(3176364..3177509) /gene="epsD" /locus_tag="BSU_34340" /old_locus_tag="BSU34340" /EC_number="2.4.-.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15175311, 15661000, 23378512, 26299781; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative extracellular matrix glycosyltransferase" /protein_id="NP_391314.1" /db_xref="EnsemblGenomes-Gn:BSU34340" /db_xref="EnsemblGenomes-Tr:CAB15439" /db_xref="GOA:P71053" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR028098" /db_xref="SubtiList:BG11862" /db_xref="UniProtKB/Swiss-Prot:P71053" /translation="MTKKILFCATVDYHFKAFHLPYFKWFKQMGWEVHVAANGQTKLP YVDEKFSIPIRRSPFDPQNLAVYRQLKKVIDTYEYDIVHCHTPVGGVLARLAARQARR HGTKVLYTAHGFHFCKGAPMKNWLLYYPVEKWLSAYTDCLITINEEDYIRAKGLQRPG GRTQKIHGIGVNTERFRPVSPIEQQRLREKHGFREDDFILVYPAELNLNKNQKQLIEA AALLKEKIPSLRLVFAGEGAMEHTYQTLAEKLGASAHVCFYGFCSDIHELIQLADVSV ASSIREGLGMNVLEGMAAEQPAIATDNRGHREIIRDGENGFLIKIGDSAAFARRIEQL YHKPELCRKLGQEGRKTALRFSEARTVEEMADIYSAYMDMDTKEKSV*" /label="epsD CDS" gene complement(3176364..3177509) /gene="epsD" /locus_tag="BSU_34340" /old_locus_tag="BSU34340" /label="epsD gene" CDS complement(3177521..3179317) /gene="epsC" /locus_tag="BSU_34350" /old_locus_tag="BSU34350" /EC_number="5.1.3.-" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15661000, 23378512, 27655338; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative UDP-sugar epimerase involved in biofilmmatrix formation" /protein_id="NP_391315.1" /db_xref="EnsemblGenomes-Gn:BSU34350" /db_xref="EnsemblGenomes-Tr:CAB15440" /db_xref="GOA:P71052" /db_xref="InterPro:IPR003869" /db_xref="InterPro:IPR029063" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11861" /db_xref="UniProtKB/Swiss-Prot:P71052" /translation="MIIALDTYLVLNSVIAGYQFLKDSYQFYDSGALLLTAVSLLLSY HVCAFLFNQYKQVWTYTGLGELIVLLKGITLSAAVTGVIQYAVYHTMFFRLLTACWVL QLLSIGGTRILSRVLNESIRKKRCASSRALIIGAGSGGTLMVRQLLSKDEPDIIPVAF IDDDQTKHKLEIMGLPVIGGKESIMPAVQKLKINYIIIAIPSLRTHELQVLYKECVRT GVSIKIMPHFDEMLLGTRTAGQIRDVKAEDLLGRKPVTLDTSEISNRIKGKTVLVTGA GGSIGSEICRQISAFQPKEIILLGHGENSIHSIYTELNGRFGKHIVFHTEIADVQDRD KMFTLMKKYEPHVVYHAAAHKHVPLMEHNPEEAVKNNIIGTKNVAEAADMSGTETFVL ISSDKAVNPANVMGATKRFAEMIIMNLGKVSRTKFVAVRFGNVLGSRGSVIPIFKKQI EKGGPVTVTHPAMTRYFMTIPEASRLVIQAGALAKGRQIFVLDMGEPVKIVDLAKNLI HLSGYTTEQVPIEFTGIRPGEKMYEELLNKNEVHAEQIFPKIHIGKAVDGDWPVLMRF IEDFHELPEADLRARLFAAINTSEEMTAASVH*" /label="epsC CDS" gene complement(3177521..3179317) /gene="epsC" /locus_tag="BSU_34350" /old_locus_tag="BSU34350" /label="epsC gene" S_feature complement(3179318..3179377) /Source="Nicolas_S_feature" /locus_tag="new_3528204_3528263_c" /HighExp="LoTm, G/S, M9-tran, BMM, MG 150, S3, S2, S4, aero, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig="0.79" /TUlongSig="NA" /TUlongPSig="NA" /label="S1312" promotor_-10 complement(3179351..3179369) /Source="Nicolas_upshift_promotors" /id="U2699" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.79020979020979" /psig="0.79020979020979" /xcortree=2767 /SigmaFactorBS="atacataggacgtattgtcggtttagctgctgccgatttttt ggagagACGAAAAccgccgcagctaaACCGATAAAAGAATTAGGGgggaaaaggttga g" /listShort="S1312, epsC, epsD, epsE, epsF, epsG, epsH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3179377) /Source="Nicolas_upshifts" /id="U2699" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.79020979020979" /psig="0.79020979020979" /xcortree=2767 /SigmaFactorBS="atacataggacgtattgtcggtttagctgctgccgatttttt ggagagACGAAAAccgccgcagctaaACCGATAAAAGAATTAGGGgggaaaaggttga g" /listShort="S1312, epsC, epsD, epsE, epsF, epsG, epsH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3179383..3179389) /Source="Nicolas_upshift_promotors" /id="U2699" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.79020979020979" /psig="0.79020979020979" /xcortree=2767 /SigmaFactorBS="atacataggacgtattgtcggtttagctgctgccgatttttt ggagagACGAAAAccgccgcagctaaACCGATAAAAGAATTAGGGgggaaaaggttga g" /listShort="S1312, epsC, epsD, epsE, epsF, epsG, epsH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3179576..3180259) /gene="epsB" /locus_tag="BSU_34360" /old_locus_tag="BSU34360" /EC_number="2.7.10.2" /function="16.3: Control" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15661000, 15741737, 24493247, 26283769, 28950882" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15661000, 15741737, 24493247, 26283769, 28950882; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein tyrosine kinase involved in biofilm matrix formation" /protein_id="NP_391316.1" /db_xref="EnsemblGenomes-Gn:BSU34360" /db_xref="EnsemblGenomes-Tr:CAB15441" /db_xref="GOA:P71051" /db_xref="InterPro:IPR005702" /db_xref="InterPro:IPR025669" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11860" /db_xref="UniProtKB/Swiss-Prot:P71051" /translation="MIFRKKKARRGLAQISVLHNKSVVAEQYRTIRTNIEFSSVQTNL RSILVTSSVPGEGKSFSAANLAAVFAQQQEKKVLLVDADLRKPTINQTFQVDNVTGLT NVLVGNASLSETVQKTPIDNLYVLTSGPTPPNPAELLSSKAMGDLISEIYEQFSLVIF DSPPLLAVADAQILANQTDGSVLVVLSGKTKTDTVLKAKDALEQSNAKLLGALLNKKK MKKSEHYSY*" /label="epsB CDS" gene complement(3179576..3180259) /gene="epsB" /locus_tag="BSU_34360" /old_locus_tag="BSU34360" /label="epsB gene" CDS complement(3180265..3180969) /gene="epsA" /locus_tag="BSU_34370" /old_locus_tag="BSU34370" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12970183, 15661000, 23378512, 26283769, 28950882; Product type r : regulator" /codon_start=1 /transl_table=11 /product="modulator of protein tyrosine kinase EpsB involved in biofilm matrix formation" /protein_id="NP_391317.1" /db_xref="EnsemblGenomes-Gn:BSU34370" /db_xref="EnsemblGenomes-Tr:CAB15442" /db_xref="GOA:P71050" /db_xref="InterPro:IPR003856" /db_xref="SubtiList:BG11859" /db_xref="UniProtKB/Swiss-Prot:P71050" /translation="MNENMSFKELYAIVRHRFVLILLITIGVTLIMGFVQFKVISPTY QASTQVLVHESDGEENSNLSDIQRNLQYSSTFQSIMKSTALMEEVKAELHLSESASSL KGKVVTSSENESEIINVAVQDHDPAKAAEIANTLVNKFEKEVDERMNVQGVHILSEAK ASESPMIKPARLRNMVMAFGAAVMGGITLAFFLHFLDDTCKSARQLSERTGLPCLGSV PDVHKGRNRGIKHFGE*" /label="epsA CDS" gene complement(3180265..3180969) /gene="epsA" /locus_tag="BSU_34370" /old_locus_tag="BSU34370" /label="epsA gene" upshifts 3180951 /Source="Nicolas_upshifts" /id="U2700" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1024 /SigmaFactorBS="cgattgtgatgagcagaatcagcacgaatctgtgtctgacaa tCgcatataattctttgaaacTCATATTCTCATTCATGTAttcatagccttcagcctt c" /listShort="slrR" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3180954..3180972 /Source="Nicolas_upshift_promotors" /id="U2700" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1024 /SigmaFactorBS="cgattgtgatgagcagaatcagcacgaatctgtgtctgacaa tCgcatataattctttgaaacTCATATTCTCATTCATGTAttcatagccttcagcctt c" /listShort="slrR" /GFF_Attribute="listLong" /label="promotor_-10" S_feature complement(3180970..3181027) /Source="Nicolas_S_feature" /locus_tag="new_3529856_3529913_c" /HighExp="LoTm, BT, S3, G/S, BMM, M9-tran, S4, aero, T1.0H, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.952" /TUlongSig="NA" /TUlongPSig="NA" /label="S1313" promotor_-10 complement(3181023..3181042) /Source="Nicolas_upshift_promotors" /id="U2701" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.441558441558442" /psig="0.952047952047952" /xcortree=2770 /SigmaFactorBS="aagagaacttattggcttattttgcAATTTTTAaataataac gtttTCTTTTATAATCCAATCATTaacagaaaggggcgcgggaagccagccgcgggaa g" /listShort="S1313, epsA, epsB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3181028) /Source="Nicolas_upshifts" /id="U2701" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.441558441558442" /psig="0.952047952047952" /xcortree=2770 /SigmaFactorBS="aagagaacttattggcttattttgcAATTTTTAaataataac gtttTCTTTTATAATCCAATCATTaacagaaaggggcgcgggaagccagccgcgggaa g" /listShort="S1313, epsA, epsB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3181056..3181063) /Source="Nicolas_upshift_promotors" /id="U2701" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.441558441558442" /psig="0.952047952047952" /xcortree=2770 /SigmaFactorBS="aagagaacttattggcttattttgcAATTTTTAaataataac gtttTCTTTTATAATCCAATCATTaacagaaaggggcgcgggaagccagccgcgggaa g" /listShort="S1313, epsA, epsB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3181145..3181150 /Source="Nicolas_upshift_promotors" /id="U2702" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.464535464535465" /psig="0.995004995004995" /xcortree=2771 /SigmaFactorBS="cctctaatttactgcacttcccttattattttaaATTTTAta aagaacgaaaaaTTCCTTATAATGAACGAAATaacgacaggaatagaggagaatttca t" /listShort="slrR" /listLong="pnbA" /label="promotor_-35" promotor_-10 3181165..3181184 /Source="Nicolas_upshift_promotors" /id="U2702" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.464535464535465" /psig="0.995004995004995" /xcortree=2771 /SigmaFactorBS="cctctaatttactgcacttcccttattattttaaATTTTAta aagaacgaaaaaTTCCTTATAATGAACGAAATaacgacaggaatagaggagaatttca t" /listShort="slrR" /listLong="pnbA" /label="promotor_-10" upshifts 3181171 /Source="Nicolas_upshifts" /id="U2702" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.464535464535465" /psig="0.995004995004995" /xcortree=2771 /SigmaFactorBS="cctctaatttactgcacttcccttattattttaaATTTTAta aagaacgaaaaaTTCCTTATAATGAACGAAATaacgacaggaatagaggagaatttca t" /listShort="slrR" /listLong="pnbA" /label="upshifts" CDS 3181215..3181673 /gene="slrR" /locus_tag="BSU_34380" /old_locus_tag="BSU34380" /function="16.5: Explore" /function="16.13: Shape" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:18430133, 18647168, 20923420, 28546427" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18430133, 18647168, 20923420, 28546427; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of autolysin genes (biofilm formation)" /protein_id="NP_391318.1" /db_xref="EnsemblGenomes-Gn:BSU34380" /db_xref="EnsemblGenomes-Tr:CAB15443" /db_xref="GOA:P71049" /db_xref="InterPro:IPR001387" /db_xref="InterPro:IPR010981" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR036281" /db_xref="SubtiList:BG11858" /db_xref="UniProtKB/Swiss-Prot:P71049" /translation="MIGRIIRLYRKRKGYSINQLAVESGVSKSYLSKIERGVHTNPSV QFLKKVSATLEVELTELFDAETMMYEKISGGEEEWRVHLVQAVQAGMEKEELFTFTNR LKKEQPETASYRNRKLTESNIEEWKALMAEAREIGLSVHEVKSFLKTKGR*" /label="slrR CDS" gene 3181215..3181673 /gene="slrR" /locus_tag="BSU_34380" /old_locus_tag="BSU34380" /label="slrR gene" promotor_-35 3181695..3181698 /Source="Nicolas_upshift_promotors" /id="U2703" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.446553446553447" /psig="0.888111888111888" /xcortree=3178 /SigmaFactorBS="aaatcctttttaaaaacaaagggaagatgatgatcggttaaa gggctaacgTTCGcatctataggggaaatCTGTTTATAATGGGGGAAAaagggagaga a" /listShort="pnbA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3181704 /Source="Nicolas_upshifts" /id="U2703" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.446553446553447" /psig="0.888111888111888" /xcortree=3178 /SigmaFactorBS="aaatcctttttaaaaacaaagggaagatgatgatcggttaaa gggctaacgTTCGcatctataggggaaatCTGTTTATAATGGGGGAAAaagggagaga a" /listShort="pnbA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3181715..3181733 /Source="Nicolas_upshift_promotors" /id="U2703" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.446553446553447" /psig="0.888111888111888" /xcortree=3178 /SigmaFactorBS="aaatcctttttaaaaacaaagggaagatgatgatcggttaaa gggctaacgTTCGcatctataggggaaatCTGTTTATAATGGGGGAAAaagggagaga a" /listShort="pnbA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3181749..3183218 /gene="pnbA" /locus_tag="BSU_34390" /old_locus_tag="BSU34390" /EC_number="3.1.1.1" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:7828905, 15138843" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7828905, 15138843; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="para-nitrobenzyl esterase (intracellular esterase B)" /protein_id="NP_391319.1" /db_xref="EnsemblGenomes-Gn:BSU34390" /db_xref="EnsemblGenomes-Tr:CAB15444" /db_xref="GOA:P37967" /db_xref="InterPro:IPR000997" /db_xref="InterPro:IPR002018" /db_xref="InterPro:IPR019819" /db_xref="InterPro:IPR019826" /db_xref="InterPro:IPR029058" /db_xref="PDB:1C7I" /db_xref="PDB:1C7J" /db_xref="PDB:1QE3" /db_xref="SubtiList:BG11844" /db_xref="UniProtKB/Swiss-Prot:P37967" /translation="MTHQIVTTQYGKVKGTTENGVHKWKGIPYAKPPVGQWRFKAPEP PEVWEDVLDATAYGSICPQPSDLLSLSYTELPRQSEDCLYVNVFAPDTPSKNLPVMVW IHGGAFYLGAGSEPLYDGSKLAAQGEVIVVTLNYRLGPFGFLHLSSFNEAYSDNLGLL DQAAALKWVRENISAFGGDPDNVTVFGESAGGMSIAALLAMPAAKGLFQKAIMESGAS RTMTKEQAASTSAAFLQVLGINEGQLDKLHTVSAEDLLKAADQLRIAEKENIFQLFFQ PALDPKTLPEEPEKAIAEGAASGIPLLIGTTRDEGYLFFTPDSDVHSQETLDAALEYL LGKPLAEKVADLYPRSLESQIHMMTDLLFWRPAVAYASAQSHYAPVWMYRFDWHPKKP PYNKAFHALELPFVFGNLDGLERMAKAEITDEVKQLSHTIQSAWITFAKTGNPSTEAV NWPAYHEETRETLILDSEITIENDPESEKRQKLFPSKGE*" /label="pnbA CDS" gene 3181749..3183218 /gene="pnbA" /locus_tag="BSU_34390" /old_locus_tag="BSU34390" /label="pnbA gene" downshifts 3183195 /Source="Nicolas_upshifts" /id="D1780" /incds=0 /nref=4 /ntot=150 /MaxReadThrough="3.66738" /MaxDrop="2.70933" /score="-9.70074934" /energy="-12.2" /TU="U2703" /idTUdmin="U2703" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" CDS 3183221..3183412 /locus_tag="BSU_34399" /old_locus_tag="BSU34399" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514003.1" /translation="MGKTGYIGAAIVVAACIIILSAVVCLRDTVYYQPMRWTGIILFF AGIVMVPAYSAKRKPGKEK*" /label="hypothetical protein CDS" gene 3183221..3183412 /locus_tag="BSU_34399" /old_locus_tag="BSU34399" /label="gene" downshifts 3183391 /Source="Nicolas_upshifts" /id="D1781" /incds=0 /nref=24 /ntot=181 /MaxReadThrough="-0.096" /MaxDrop="4.20686" /score="34.8993337" /energy="-22.3" /TU="NA" /idTUdmin="U2703" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" CDS complement(3183439..3183924) /gene="padC" /locus_tag="BSU_34400" /old_locus_tag="BSU34400" /EC_number="4.1.1.102" /EC_number="4.1.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9546183, 12903944, 17295427, 18326577, 21685295, 26658822" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9546183, 12903944, 17295427, 18326577, 21685295, 26658822; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="phenolic acid decarboxylase" /protein_id="NP_391320.1" /db_xref="EnsemblGenomes-Gn:BSU34400" /db_xref="EnsemblGenomes-Tr:CAB15445" /db_xref="GOA:O07006" /db_xref="InterPro:IPR008729" /db_xref="InterPro:IPR012674" /db_xref="PDB:2P8G" /db_xref="PDB:4ALB" /db_xref="SubtiList:BG12433" /db_xref="UniProtKB/Swiss-Prot:O07006" /translation="MENFIGSHMIYTYENGWEYEIYIKNDHTIDYRIHSGMVAGRWVR DQEVNIVKLTEGVYKVSWTEPTGTDVSLNFMPNEKRMHGIIFFPKWVHEHPEITVCYQ NDHIDLMKESREKYETYPKYVVPEFAEITFLKNEGVDNEEVISKAPYEGMTDDIRAGR L*" /label="padC CDS" gene complement(3183439..3183924) /gene="padC" /locus_tag="BSU_34400" /old_locus_tag="BSU34400" /label="padC gene" CDS complement(3183947..3184258) /gene="yveG" /locus_tag="BSU_34410" /old_locus_tag="BSU34410" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /db_xref="EnsemblGenomes-Gn:BSU34410" /db_xref="EnsemblGenomes-Tr:CAB15446" /db_xref="GOA:O07005" /db_xref="InterPro:IPR011250" /db_xref="InterPro:IPR020915" /db_xref="PSEUDO:CAB15446.2" /db_xref="SubtiList:BG12432" /db_xref="UniProtKB/Swiss-Prot:O07005" /translation="MPGGADSQMIRANGRTDLSARYVIETADHELIYIENNGIRQVSK PFRKQAAAGEIIEPEHVYFRTVPTFETGSEVYQWLHDRLFIGSAERTPDYVLLDIYEV Q*" /label="yveG CDS" gene complement(3183947..3184258) /gene="yveG" /locus_tag="BSU_34410" /old_locus_tag="BSU34410" /pseudo /label="yveG gene" CDS complement(3184310..3184402) /gene="yveF" /locus_tag="BSU_34420" /old_locus_tag="BSU34420" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="EnsemblGenomes-Gn:BSU34420" /db_xref="EnsemblGenomes-Tr:CAB15447" /db_xref="PSEUDO:CAB15447.1" /db_xref="SubtiList:BG12431" /db_xref="UniProtKB/Swiss-Prot:O07004" /translation="MKKPVLKPFASLEIKVDPPITIGETSLGLR*" /label="yveF CDS" gene complement(3184310..3184402) /gene="yveF" /locus_tag="BSU_34420" /old_locus_tag="BSU34420" /pseudo /label="yveF gene" promotor_-10 complement(3184442..3184461) /Source="Nicolas_upshift_promotors" /id="U2704" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.66033966033966" /psig=1 /xcortree=3185 /SigmaFactorBS="ctgtcttcaaacagtccttgtttttttatgttcctatTGTTT GACagttaactgcaatGGTGTTAAAGTGAACATGTAaatagttacatgattttttctg a" /listShort="yveF, yveG, padC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3184459) /Source="Nicolas_upshifts" /id="U2704" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.66033966033966" /psig=1 /xcortree=3185 /SigmaFactorBS="ctgtcttcaaacagtccttgtttttttatgttcctatTGTTT GACagttaactgcaatGGTGTTAAAGTGAACATGTAaatagttacatgattttttctg a" /listShort="yveF, yveG, padC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3184475..3184482) /Source="Nicolas_upshift_promotors" /id="U2704" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.66033966033966" /psig=1 /xcortree=3185 /SigmaFactorBS="ctgtcttcaaacagtccttgtttttttatgttcctatTGTTT GACagttaactgcaatGGTGTTAAAGTGAACATGTAaatagttacatgattttttctg a" /listShort="yveF, yveG, padC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3184533..3185216) /gene="racX" /locus_tag="BSU_34430" /old_locus_tag="BSU34430" /EC_number="5.1.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9987136, 19063962, 2054383, 28894939" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9987136, 19063962, 2054383, 28894939; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="promiscuous aminoacid racemase (prefers arginine, lysine and ornithine)" /protein_id="NP_391323.1" /db_xref="EnsemblGenomes-Gn:BSU34430" /db_xref="EnsemblGenomes-Tr:CAB15448" /db_xref="GOA:P32960" /db_xref="InterPro:IPR001920" /db_xref="InterPro:IPR004380" /db_xref="InterPro:IPR015942" /db_xref="InterPro:IPR018187" /db_xref="InterPro:IPR033134" /db_xref="SubtiList:BG10391" /db_xref="UniProtKB/Swiss-Prot:P32960" /translation="MIGILAGMGPKSTSPFIDKVIDYCQKLYGASNDIDYPHMMIYSC PTPFYADRPIDHDEMKKAIIDGAVKLEKTGVDFIALPCNTAHVYYEEIQQALSVPMLH IVEETIKEIPHPAKKAVVLGTEPTIQSAIYQKVLKGNGQEVIHKDHWQQAVNQLIAAI KQPNHMQHTQALWQTLYEEISQHADIIISACTDLNAVLDHIQSEIPIIDSSACLAKST VSTYLAYQS*" /label="racX CDS" gene complement(3184533..3185216) /gene="racX" /locus_tag="BSU_34430" /old_locus_tag="BSU34430" /label="racX gene" downshifts complement(3184551) /Source="Nicolas_upshifts" /id="D1782" /incds=0 /nref=122 /ntot=223 /MaxReadThrough="3.49026" /MaxDrop="5.32077" /score="5.15607483" /energy="-9.3" /TU="U2705" /idTUdmin="U2704" /TUdmin="-708" /isTUend="FALSE" /label="downshifts" CDS complement(3185232..3186587) /gene="pbpE" /locus_tag="BSU_34440" /old_locus_tag="BSU34440" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:7592498, 9987136, 12533473, 14679248, 19063962" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7592498, 9987136, 12533473, 14679248, 19063962; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="penicillin-binding protein 4*" /protein_id="NP_391324.1" /db_xref="EnsemblGenomes-Gn:BSU34440" /db_xref="EnsemblGenomes-Tr:CAB15449" /db_xref="GOA:P32959" /db_xref="InterPro:IPR001466" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR021860" /db_xref="SubtiList:BG10390" /db_xref="UniProtKB/Swiss-Prot:P32959" /translation="MKQNKRKHLQTLFETLGEKHQFNGTVLAAEGGDILYHHSFGYAE MTEKRPLKTNSLFELASLSKPFTALGIILLEEKGILGYEDKVDRWLPGFPYQGVTIRH LLNHTSGLPDYMGWFFANWDSHKIAVNQDIVDMLMNEGLSGYFEPNEGWMYSNTGYVL LAVIIEKASGMSYADFIKTSIFLPAGMNETRVYNRRLSPERIDHYAYGYVYDVHSETY VLPDELEETNYVVYLDGIQGDGTVNSVTSDLFRFDQALYQDDFISKASKESAFSPVRL NNGETIDYGFGWVLQNSPEKGRIVSHSGGWPGYSTMMIRYIDHRKTLIYLSNKEEDTE YEQAILKAAEHILFGQPYDVPERPADKKKKAIDTAIYSRYVGSYLLQDGTAAQVTTEN ERLYLEIAGQLRLELFPSSETRFFLRALSVEVEFTLGEDAAKSFILYEDGSEEEAVRT K*" /label="pbpE CDS" gene complement(3185232..3186587) /gene="pbpE" /locus_tag="BSU_34440" /old_locus_tag="BSU34440" /label="pbpE gene" promotor_-10 complement(3186599..3186614) /Source="Nicolas_upshift_promotors" /id="U2705" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1687 /SigmaFactorBS="gttaaaaaggatctctaactgaaggatttttcaaaatattTG AAACGTTAgtaggttagtaACGTACAGAGATATGGgaggtggaggaatgaagcagaat a" /listShort="pbpE, racX, yveF, yveG, padC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3186615) /Source="Nicolas_upshifts" /id="U2705" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1687 /SigmaFactorBS="gttaaaaaggatctctaactgaaggatttttcaaaatattTG AAACGTTAgtaggttagtaACGTACAGAGATATGGgaggtggaggaatgaagcagaat a" /listShort="pbpE, racX, yveF, yveG, padC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3186626..3186635) /Source="Nicolas_upshift_promotors" /id="U2705" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1687 /SigmaFactorBS="gttaaaaaggatctctaactgaaggatttttcaaaatattTG AAACGTTAgtaggttagtaACGTACAGAGATATGGgaggtggaggaatgaagcagaat a" /listShort="pbpE, racX, yveF, yveG, padC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3186889..3186896 /Source="Nicolas_upshift_promotors" /id="U2706" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.865134865134865" /psig="0.998001998001998" /xcortree=1753 /SigmaFactorBS="ttatgattttctatcaaacaaaagaggaaaatagacCAGTTG CAatccaaacgagagTCTAATAGAATGAGGTCGAAaagtaaatcgcgcgggtttgtta c" /listShort="S1314, sacB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3186910..3186929 /Source="Nicolas_upshift_promotors" /id="U2706" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.865134865134865" /psig="0.998001998001998" /xcortree=1753 /SigmaFactorBS="ttatgattttctatcaaacaaaagaggaaaatagacCAGTTG CAatccaaacgagagTCTAATAGAATGAGGTCGAAaagtaaatcgcgcgggtttgtta c" /listShort="S1314, sacB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3186913 /Source="Nicolas_upshifts" /id="U2706" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.865134865134865" /psig="0.998001998001998" /xcortree=1753 /SigmaFactorBS="ttatgattttctatcaaacaaaagaggaaaatagacCAGTTG CAatccaaacgagagTCTAATAGAATGAGGTCGAAaagtaaatcgcgcgggtttgtta c" /listShort="S1314, sacB" /GFF_Attribute="listLong" /label="upshifts" S_feature 3186935..3187125 /Source="Nicolas_S_feature" /locus_tag="new_3535821_3536011" /HighExp="G150, G180, G135, LBGexp, Mt0, Lbexp, LBGtran, dia0, GM 150, MG 60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.219024" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1314" CDS 3187126..3188547 /gene="sacB" /locus_tag="BSU_34450" /old_locus_tag="BSU34450" /EC_number="2.4.1.10" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1400159, 11200435, 11320136, 11739774, 17704766, 15528654, 26600431" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1400159, 11200435, 11320136, 11739774, 17704766, 15528654, 26600431; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="levansucrase; levanase (moonlighting)" /protein_id="NP_391325.1" /db_xref="EnsemblGenomes-Gn:BSU34450" /db_xref="EnsemblGenomes-Tr:CAB15450" /db_xref="GOA:P05655" /db_xref="InterPro:IPR003469" /db_xref="InterPro:IPR023296" /db_xref="PDB:1OYG" /db_xref="PDB:1PT2" /db_xref="PDB:2VDT" /db_xref="PDB:3BYJ" /db_xref="PDB:3BYK" /db_xref="PDB:3BYL" /db_xref="PDB:3BYN" /db_xref="SubtiList:BG10388" /db_xref="UniProtKB/Swiss-Prot:P05655" /translation="MNIKKFAKQATVLTFTTALLAGGATQAFAKETNQKPYKETYGIS HITRHDMLQIPEQQKNEKYQVPEFDSSTIKNISSAKGLDVWDSWPLQNADGTVANYHG YHIVFALAGDPKNADDTSIYMFYQKVGETSIDSWKNAGRVFKDSDKFDANDSILKDQT QEWSGSATFTSDGKIRLFYTDFSGKHYGKQTLTTAQVNVSASDSSLNINGVEDYKSIF DGDGKTYQNVQQFIDEGNYSSGDNHTLRDPHYVEDKGHKYLVFEANTGTEDGYQGEES LFNKAYYGKSTSFFRQESQKLLQSDKKRTAELANGALGMIELNDDYTLKKVMKPLIAS NTVTDEIERANVFKMNGKWYLFTDSRGSKMTIDGITSNDIYMLGYVSNSLTGPYKPLN KTGLVLKMDLDPNDVTFTYSHFAVPQAKGNNVVITSYMTNRGFYADKQSTFAPSFLLN IKGKKTSVVKDSILEQGQLTVNK*" /label="sacB CDS" gene 3187126..3188547 /gene="sacB" /locus_tag="BSU_34450" /old_locus_tag="BSU34450" /label="sacB gene" downshifts 3188541 /Source="Nicolas_upshifts" /id="D1783" /incds=0 /nref=2 /ntot=27 /MaxReadThrough="2.33324" /MaxDrop="3.39023" /score="9.57663013" /energy="-7.7" /TU="NA" /idTUdmin="U2706" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 3188621..3190171 /gene="levB" /locus_tag="BSU_34460" /old_locus_tag="BSU34460" /EC_number="3.2.1.64" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11739774, 15528654, 26773563" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11739774, 15528654, 26773563; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endolevanase, selectively cleaves the (beta-2,6)fructosyl bonds" /protein_id="NP_391326.1" /db_xref="EnsemblGenomes-Gn:BSU34460" /db_xref="EnsemblGenomes-Tr:CAB15451" /db_xref="GOA:O07003" /db_xref="InterPro:IPR001362" /db_xref="InterPro:IPR013148" /db_xref="InterPro:IPR013189" /db_xref="InterPro:IPR013320" /db_xref="InterPro:IPR023296" /db_xref="SubtiList:BG12430" /db_xref="UniProtKB/Swiss-Prot:O07003" /translation="MNYIKAGKWLTVFLTFLGILLFIDLFPKEEHDQKTKSKQKPDYR AAYHFTTPDKWKNDPQKPIYFDGKYHYFYLYNRDYPKGNGTEWRHAVSEDLVHWTDEG VAIPKYTNPDGDIWTGSVVVDKENTAGFGKNALVAIVTQPSAKDKKQEQYLWYSTDKG KSFKFYSGNPVMPNPGTDDFRDPKVIWDDQDNKWVMVMAEGSKIGFYESDNLKDWHYT SGFFPEQAGMVECPDLYMMRASDGTNKWVLGASANGKPWGKPNTYAYWTGSFDGKEFK ADQTEAQWLDYGFDWYGGVTFEDSKSTDPLEKRYALAWMNNWDYANNTPTMKNGFNGT DSVIRELRLKEQDGTYSLVSQPIEALEQLTVSTDEIEDQDVNGSKTLSITGDTYQLDT DLSWSELKNAGVRLRESEDQKRHIDVGIFAEGGYAYVNRAATNQPDKSNTYVESKAPY DVNKRKVHLKILVDKTTIEVFVGDGKTVFSNEVFPKPEDKGITLYSDGGTASFKNITV KHFDSIHE*" /label="levB CDS" gene 3188621..3190171 /gene="levB" /locus_tag="BSU_34460" /old_locus_tag="BSU34460" /label="levB gene" promotor_-35 3190215..3190221 /Source="Nicolas_upshift_promotors" /id="U2707" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=926 /SigmaFactorBS="caggggcggcgcaggctgcccctgtttttttattaggagcGG TATTCtctgttacatattGGGCATTGTAAGgaatataaggctggtttcaaaggaggaa g" /listShort="yveA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3190235..3190246 /Source="Nicolas_upshift_promotors" /id="U2707" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=926 /SigmaFactorBS="caggggcggcgcaggctgcccctgtttttttattaggagcGG TATTCtctgttacatattGGGCATTGTAAGgaatataaggctggtttcaaaggaggaa g" /listShort="yveA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3190235 /Source="Nicolas_upshifts" /id="U2707" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=926 /SigmaFactorBS="caggggcggcgcaggctgcccctgtttttttattaggagcGG TATTCtctgttacatattGGGCATTGTAAGgaatataaggctggtttcaaaggaggaa g" /listShort="yveA" /GFF_Attribute="listLong" /label="upshifts" CDS 3190279..3191841 /gene="aspP" /locus_tag="BSU_34470" /old_locus_tag="BSU34470" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12730183, 15528654, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12730183, 15528654, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="L-aspartate/L-glutamate / proton permease" /protein_id="NP_391327.1" /db_xref="EnsemblGenomes-Gn:BSU34470" /db_xref="EnsemblGenomes-Tr:CAB15452" /db_xref="GOA:O07002" /db_xref="InterPro:IPR002293" /db_xref="SubtiList:BG12429" /db_xref="UniProtKB/Swiss-Prot:O07002" /translation="MSKQGNFQKSMSLFDLILIGMGAIFGSAWLFAVSNVASKAGPSG AFSWILGGAIILLIGLVYAELGAALPRTGGIIRYPVYSHGHLVGYLISFVTIVAYTSL ISIEVTAVRQYVAYWFPGLTIKGSDSPTISGWILQFALLCLFFLLNYWSVKTFAKANF IISIFKYIVPITIIIVLIFHFQPENLSVQGFAPFGFTGIQAAISTGGVMFAYLGLHPI VSVAGEVQNPKRNIPIALIICIIVSTIIYTVLQVTFIGAIPTETLKHGWPAIGREFSL PFKDIAVMLGLGWLATLVILDAILSPGGNGNIFMNTTSRLVYAWARNGTLFGIFSKVN KDTGTPRASLWLSFALSIFWTLPFPSWNALVNVCSVALILSYAIAPISSAALRVNAKD LNRPFYLKGMSIIGPLSFIFTAFIVYWSGWKTVSWLLGSQLVMFLIYLCFSKYTPKED VSLAQQLKSAWWLIGFYIMMLIFSYIGSFGHGLGIISNPVDLILVAIGSLAIYYWAKY TGLPKAAIDYDK*" /label="aspP CDS" gene 3190279..3191841 /gene="aspP" /locus_tag="BSU_34470" /old_locus_tag="BSU34470" /label="aspP gene" downshifts 3191819 /Source="Nicolas_upshifts" /id="D1784" /incds=0 /nref=12 /ntot=29 /MaxReadThrough="1.71122" /MaxDrop="3.47798" /score="-0.444529447" /energy="-11.7" /TU="NA" /idTUdmin="U2707" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 3191831..3192520 /gene="yvdT" /locus_tag="BSU_34480" /old_locus_tag="BSU34480" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (TetR/AcrR family)" /protein_id="NP_391328.2" /db_xref="EnsemblGenomes-Gn:BSU34480" /db_xref="EnsemblGenomes-Tr:CAB15453" /db_xref="GOA:O07001" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036271" /db_xref="PDB:2F07" /db_xref="SubtiList:BG12428" /db_xref="UniProtKB/Swiss-Prot:O07001" /translation="MINKEARGFLASLFFTNKHTRDKMNESQSLLEVFLMPKQTSGKY EKILQAAIEVISEKGLDKASISDIVKKAGTAQGTFYLYFSSKNALIPAIAENLLTHTL DQIKGRLHGDEDFWTVLDILIDETFLITERHKDIIVLCYSGLAIDHSMEKWETIYQPY YSWLEKIINKAIANHEVTEGINSKWTARTIINLVENTAERFYIGFEQDENVEVYKKEI FTFLKRSLGTA*" /label="yvdT CDS" gene 3191831..3192520 /gene="yvdT" /locus_tag="BSU_34480" /old_locus_tag="BSU34480" /label="yvdT gene" promotor_-35 3191870..3191877 /Source="Nicolas_upshift_promotors" /id="U2708" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.573426573426573" /psig="0.999000999001" /xcortree=2082 /SigmaFactorBS="aaagaagcaagaggttttcttgcttctttaTTCTTTACaaac aaacatacaCGCGATAAAATGAATGAGAGtcagtcattactggaggtgttcctcatgc c" /listShort="yvdT, yvdS, yvdR, S1315" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3191891..3191910 /Source="Nicolas_upshift_promotors" /id="U2708" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.573426573426573" /psig="0.999000999001" /xcortree=2082 /SigmaFactorBS="aaagaagcaagaggttttcttgcttctttaTTCTTTACaaac aaacatacaCGCGATAAAATGAATGAGAGtcagtcattactggaggtgttcctcatgc c" /listShort="yvdT, yvdS, yvdR, S1315" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3191900 /Source="Nicolas_upshifts" /id="U2708" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.573426573426573" /psig="0.999000999001" /xcortree=2082 /SigmaFactorBS="aaagaagcaagaggttttcttgcttctttaTTCTTTACaaac aaacatacaCGCGATAAAATGAATGAGAGtcagtcattactggaggtgttcctcatgc c" /listShort="yvdT, yvdS, yvdR, S1315" /GFF_Attribute="listLong" /label="upshifts" downshifts 3192501 /Source="Nicolas_upshifts" /id="D1785" /incds=0 /nref=189 /ntot=242 /MaxReadThrough="4.85194" /MaxDrop="4.84113" /score="-0.444529447" /energy="-11.7" /TU="U2708" /idTUdmin="U2707" /TUdmin=682 /isTUend="FALSE" /label="downshifts" downshifts complement(3192599) /Source="Nicolas_upshifts" /id="D1786" /incds=0 /nref=1 /ntot=8 /MaxReadThrough="0.8852" /MaxDrop="3.45447" /score="0.398849185" /energy="-11.7" /TU="NA" /idTUdmin="U2709" /TUdmin=704 /isTUend="FALSE" /label="downshifts" CDS 3192602..3192937 /gene="psmA" /locus_tag="BSU_34490" /old_locus_tag="BSU34490" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 22978536; Product type t : transporter" /codon_start=1 /transl_table=11 /product="sodium / proton antiporter subunit A" /protein_id="NP_391329.1" /db_xref="EnsemblGenomes-Gn:BSU34490" /db_xref="EnsemblGenomes-Tr:CAB15454" /db_xref="GOA:O32262" /db_xref="InterPro:IPR000390" /db_xref="SubtiList:BG12427" /db_xref="UniProtKB/Swiss-Prot:O32262" /translation="MNWVLVFIAGLLEVVWASSLKHADSLLDWIIIFILIAVSFILLI RSYQKIPMAAAYTVFVGIGTVGTYLTGIVLGESFSAAQMFFLALLLAGILGMKLFTKE SKSQPGGEK*" /label="psmA CDS" gene 3192602..3192937 /gene="psmA" /locus_tag="BSU_34490" /old_locus_tag="BSU34490" /label="psmA gene" CDS 3192937..3193257 /gene="psmB" /locus_tag="BSU_34500" /old_locus_tag="BSU34500" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11160890, 22978536; Product type t: transporter" /codon_start=1 /transl_table=11 /product="sodium-proton two component antiporter subunit" /protein_id="NP_391330.1" /db_xref="EnsemblGenomes-Gn:BSU34500" /db_xref="EnsemblGenomes-Tr:CAB15455" /db_xref="GOA:O06999" /db_xref="InterPro:IPR000390" /db_xref="SubtiList:BG12426" /db_xref="UniProtKB/Swiss-Prot:O06999" /translation="MAWFLLVIAGIEEIIAAIAMKYIDGTRKKWPIIVMTVGFGLSFY CLSQAMIVLPAGVAYAVWTGIGSIGVSAVGLIWFKERFQLSQVISLCLILAGVIGLRL TSSS*" /label="psmB CDS" gene 3192937..3193257 /gene="psmB" /locus_tag="BSU_34500" /old_locus_tag="BSU34500" /label="psmB gene" S_feature 3193258..3193448 /Source="Nicolas_S_feature" /locus_tag="new_3542144_3542334" /HighExp="Sw, BC, BI, Lbstat, M0t90, Lbtran, M40t90, H2O2, S8, Paraq" /AntisenseName="yvdQ" /AntisenseCor="3.5547360410813897E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1315" CDS complement(3193293..3193805) /gene="yvdQ" /locus_tag="BSU_34510" /old_locus_tag="BSU34510" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391331.1" /db_xref="EnsemblGenomes-Gn:BSU34510" /db_xref="EnsemblGenomes-Tr:CAB15456" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR021617" /db_xref="SubtiList:BG12425" /db_xref="UniProtKB/Swiss-Prot:O06998" /translation="MGILSGNPQDEPMHYGEVFGLWSYVMAGNKMVGNYQMLLNHVGD DDLKKLLRESIEKCQDEIKQVSTILKENGVALPPASPEPPTADLNDIPPGARFLDPDV AASAAAENAAGLVTCSKMMGQSIREDIAMMFGQFHMSKAATGAKYLRLLKNKGWLIPP PLHLQKHHEA*" /label="yvdQ CDS" gene complement(3193293..3193805) /gene="yvdQ" /locus_tag="BSU_34510" /old_locus_tag="BSU34510" /label="yvdQ gene" downshifts 3193425 /Source="Nicolas_upshifts" /id="D1787" /incds=1 /nref=6 /ntot=39 /MaxReadThrough="1.61612" /MaxDrop="4.65362" /score="0.608596632" /energy="-14.2" /TU="NA" /idTUdmin="U2708" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3193841..3193852) /Source="Nicolas_upshift_promotors" /id="U2709" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=891 /SigmaFactorBS="tgttttgtttcatttcataaatcttttccgctgaAACATAAa tgttcctccgcttGGGCACGTTATGaaatgtgcaatattgaatatgggaggagaatga g" /listShort="yvdQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3193847) /Source="Nicolas_upshifts" /id="U2709" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=891 /SigmaFactorBS="tgttttgtttcatttcataaatcttttccgctgaAACATAAa tgttcctccgcttGGGCACGTTATGaaatgtgcaatattgaatatgggaggagaatga g" /listShort="yvdQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3193867..3193873) /Source="Nicolas_upshift_promotors" /id="U2709" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=891 /SigmaFactorBS="tgttttgtttcatttcataaatcttttccgctgaAACATAAa tgttcctccgcttGGGCACGTTATGaaatgtgcaatattgaatatgggaggagaatga g" /listShort="yvdQ" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3193920..3194056) /Source="Nicolas_S_feature" /locus_tag="new_3542806_3542942_c" /HighExp="BT, S7, S8, S6, B36, G/S, S5, Pyr, G135, S4" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1316" downshifts complement(3193963) /Source="Nicolas_upshifts" /id="D1788" /incds=0 /nref=1 /ntot=38 /MaxReadThrough="3.38169" /MaxDrop="2.9968" /score="15.2862513" /energy="-10.3" /TU="U2710" /idTUdmin="U2709" /TUdmin="-660" /isTUend="FALSE" /label="downshifts" CDS complement(3194057..3195400) /gene="cotNP" /locus_tag="BSU_34520" /old_locus_tag="BSU34520" /EC_number="1.-.-.-" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12562816" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12562816; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore coat protein; putative oxidoreductase" /protein_id="NP_391332.1" /db_xref="EnsemblGenomes-Gn:BSU34520" /db_xref="EnsemblGenomes-Tr:CAB15457" /db_xref="GOA:O06997" /db_xref="InterPro:IPR006094" /db_xref="InterPro:IPR012951" /db_xref="InterPro:IPR016166" /db_xref="InterPro:IPR016167" /db_xref="InterPro:IPR016169" /db_xref="InterPro:IPR036318" /db_xref="SubtiList:BG12424" /db_xref="UniProtKB/Swiss-Prot:O06997" /translation="MGSTQLTGRVIFKGDPGYTEAIKNWNPYVDVYPLVFVFAQNSYD VSNAIKWARENKVPLRVRSGRHALDKNLSVVSGGIVIDVSDMNKVFLDEENAIATVQT GIPVGPLVKGLARDGFMAPFGDSPTVGIGGITMGGGFGVLSRSIGLISDNLLALKTVD AKGRIIHADQSHNEDLLWASRGGGGGNFGYNTQYTFKVHRAPKTATVFNIIWPWEQLE TVFKAWQKWAPFVDERLGCYLEIYSKINGLCHAEGIFLGSKTELIRLLKPLLHAGTPT EADIKTLYYPDAIDFLDPDEPIPGRNDQSVKFSSAWGHDFWSDEPISIMRKFLEDATG TEANFFFINWGGAISRVPKDETAFFWRHPLFYTEWTASWKNKSQEDSNLASVERVRQL MQPYVAGSYVNVPDQNIENFGKEYYGANFARLREIKAKYDPENVFRFPQSIPPSR*" /label="cotNP CDS" gene complement(3194057..3195400) /gene="cotNP" /locus_tag="BSU_34520" /old_locus_tag="BSU34520" /label="cotNP gene" promotor_-10 complement(3195429..3195448) /Source="Nicolas_upshift_promotors" /id="U2710" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1342 /SigmaFactorBS="attatatttatagttcgtagatcatttGTCTATGCGAttatc cagctccTGCATATTTTAGTATCTGAAtcgaatttctttgggagtgaaataatatatg g" /listShort="yvdP, S1316, yvdQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3195437) /Source="Nicolas_upshifts" /id="U2710" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1342 /SigmaFactorBS="attatatttatagttcgtagatcatttGTCTATGCGAttatc cagctccTGCATATTTTAGTATCTGAAtcgaatttctttgggagtgaaataatatatg g" /listShort="yvdP, S1316, yvdQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3195461..3195470) /Source="Nicolas_upshift_promotors" /id="U2710" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1342 /SigmaFactorBS="attatatttatagttcgtagatcatttGTCTATGCGAttatc cagctccTGCATATTTTAGTATCTGAAtcgaatttctttgggagtgaaataatatatg g" /listShort="yvdP, S1316, yvdQ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3195462..3195467 /Source="Nicolas_upshift_promotors" /id="U2711" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1039 /SigmaFactorBS="cgattcagatactaaaatatgcaggagctggataatCGCATA gacaaatgatctacgAACTATAAATATAATACGCtaaggcctttttcgtcggtgaggt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3195483..3195501 /Source="Nicolas_upshift_promotors" /id="U2711" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1039 /SigmaFactorBS="cgattcagatactaaaatatgcaggagctggataatCGCATA gacaaatgatctacgAACTATAAATATAATACGCtaaggcctttttcgtcggtgaggt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3195486 /Source="Nicolas_upshifts" /id="U2711" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.986013986013986" /psig="0.986013986013986" /xcortree=1039 /SigmaFactorBS="cgattcagatactaaaatatgcaggagctggataatCGCATA gacaaatgatctacgAACTATAAATATAATACGCtaaggcctttttcgtcggtgaggt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3195695..3195704 /Source="Nicolas_upshift_promotors" /id="U2712" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1360 /SigmaFactorBS="aagaaaagagagatgaagaagtgtttagtaccagaggtatac ATCCATACAAcagactctagatcATCATATACTGAATGTATGTagaaaggagacatca g" /listShort="cotR, S1317" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3195713 /Source="Nicolas_upshifts" /id="U2712" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1360 /SigmaFactorBS="aagaaaagagagatgaagaagtgtttagtaccagaggtatac ATCCATACAAcagactctagatcATCATATACTGAATGTATGTagaaaggagacatca g" /listShort="cotR, S1317" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3195718..3195737 /Source="Nicolas_upshift_promotors" /id="U2712" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1360 /SigmaFactorBS="aagaaaagagagatgaagaagtgtttagtaccagaggtatac ATCCATACAAcagactctagatcATCATATACTGAATGTATGTagaaaggagacatca g" /listShort="cotR, S1317" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3195756..3196718 /gene="cotR" /locus_tag="BSU_34530" /old_locus_tag="BSU34530" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11737650, 20378985" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11737650, 20378985; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore coat lipolytic enzyme" /protein_id="NP_391333.1" /db_xref="EnsemblGenomes-Gn:BSU34530" /db_xref="EnsemblGenomes-Tr:CAB15458" /db_xref="GOA:O06996" /db_xref="InterPro:IPR002641" /db_xref="InterPro:IPR016035" /db_xref="SubtiList:BG12423" /db_xref="UniProtKB/Swiss-Prot:O06996" /translation="MAKYRIMTFDGGGTLGALSLQLLNRLARQNPKLISRTHVFSGNS IGSFTALALASGRSPRETLQYFEDEILPAFSISRPGGPVFNQQLPYSGFIKAVRNFFP ADLQLIDLRKRIVVPSFKLYSQKLDRWTPVLFHNFPGSPYLNEKVSDVILRSSGAPAT QRAYQNYVDGYVVATNPSTASIAFAVGKANVPLDQIAVLSIGTGEAPTRLRRDTRGWG MVSADNIRPENLKNLPPNWGVLLDRSPNEPLLPFLQMIAGGNGYYESMVSANLLGDRF FRLDPRIPNFSKTDPAVVPAVIEIANKTNLQPANQFIEKNWGSK*" /label="cotR CDS" gene 3195756..3196718 /gene="cotR" /locus_tag="BSU_34530" /old_locus_tag="BSU34530" /label="cotR gene" S_feature 3196719..3196972 /Source="Nicolas_S_feature" /locus_tag="new_3545605_3545858" /HighExp="BT, S8, S7, B36, S6, Pyr, G/S, S3, C30, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1317" downshifts complement(3196999) /Source="Nicolas_upshifts" /id="D1789" /incds=0 /nref=190 /ntot=241 /MaxReadThrough="3.19421" /MaxDrop="5.60739" /score="16.7489574" /energy="-13.2" /TU="U2713" /idTUdmin="U2713" /TUdmin="-308" /isTUend="FALSE" /label="downshifts" tRNA complement(3197003..3197078) /gene="trnQ-Arg" /locus_tag="BSU_tRNA_81" /product="tRNA-Arg" /inference="profile:tRNAscan:1.23" /note="arginine transfer RNA (CCG); Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 27749819; Product type n : RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnQ-Arg tRNA" gene complement(3197003..3197078) /gene="trnQ-Arg" /locus_tag="BSU_tRNA_81" /label="trnQ-Arg gene" promotor_-10 complement(3197105..3197124) /Source="Nicolas_upshift_promotors" /id="U2713" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.508491508491508" /psig=1 /xcortree=2857 /SigmaFactorBS="aagatgctttgtctatttaaaaaacggcctctcgaaatagag gGTTGttatttgaaaggaatTATCGTATAATTAGTTGTGCtgacgttctcataacgca g" /listShort="trnQ-Arg" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3197126) /Source="Nicolas_upshifts" /id="U2713" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.508491508491508" /psig=1 /xcortree=2857 /SigmaFactorBS="aagatgctttgtctatttaaaaaacggcctctcgaaatagag gGTTGttatttgaaaggaatTATCGTATAATTAGTTGTGCtgacgttctcataacgca g" /listShort="trnQ-Arg" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3197140..3197143) /Source="Nicolas_upshift_promotors" /id="U2713" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.508491508491508" /psig=1 /xcortree=2857 /SigmaFactorBS="aagatgctttgtctatttaaaaaacggcctctcgaaatagag gGTTGttatttgaaaggaatTATCGTATAATTAGTTGTGCtgacgttctcataacgca g" /listShort="trnQ-Arg" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3197209..3197215 /Source="Nicolas_upshift_promotors" /id="U2714" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=726 /SigmaFactorBS="ttttaaatagacaaagcatcttaattggcaatctgacatacg atGGTTTGAacccctgtatttttGGGGAAAATGGGAAAAAGAGacgactttgcatatc a" /listShort="S1318, clpP, S1319" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3197225..3197300 /Source="Nicolas_S_feature" /locus_tag="new_3546111_3546186" /HighExp="Salt, S3, S4, Etha, S5, LoTm, Gly, M9-stat, BT, S6" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1318" upshifts 3197225 /Source="Nicolas_upshifts" /id="U2714" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=726 /SigmaFactorBS="ttttaaatagacaaagcatcttaattggcaatctgacatacg atGGTTTGAacccctgtatttttGGGGAAAATGGGAAAAAGAGacgactttgcatatc a" /listShort="S1318, clpP, S1319" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3197230..3197249 /Source="Nicolas_upshift_promotors" /id="U2714" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=726 /SigmaFactorBS="ttttaaatagacaaagcatcttaattggcaatctgacatacg atGGTTTGAacccctgtatttttGGGGAAAATGGGAAAAAGAGacgactttgcatatc a" /listShort="S1318, clpP, S1319" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 3197277..3197284 /Source="Nicolas_upshift_promotors" /id="U2715" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.975024975024975" /psig=1 /xcortree=1938 /SigmaFactorBS="aaaaagagacgactttgcatatcaggccagcttttTGTTTGA CctttattgaccaaAAATGTATCATGTAACTACAtacttacctaaaaggtgaaggagg a" /listShort="clpP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3197298..3197317 /Source="Nicolas_upshift_promotors" /id="U2715" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.975024975024975" /psig=1 /xcortree=1938 /SigmaFactorBS="aaaaagagacgactttgcatatcaggccagcttttTGTTTGA CctttattgaccaaAAATGTATCATGTAACTACAtacttacctaaaaggtgaaggagg a" /listShort="clpP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3197302 /Source="Nicolas_upshifts" /id="U2715" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.975024975024975" /psig=1 /xcortree=1938 /SigmaFactorBS="aaaaagagacgactttgcatatcaggccagcttttTGTTTGA CctttattgaccaaAAATGTATCATGTAACTACAtacttacctaaaaggtgaaggagg a" /listShort="clpP" /GFF_Attribute="listLong" /label="upshifts" CDS 3197348..3197941 /gene="clpP" /locus_tag="BSU_34540" /old_locus_tag="BSU34540" /EC_number="3.4.21.92" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11722737, 11807061, 15317791, 16163393, 21546913, 21969594, 22226636, 27749819" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11722737, 11807061, 15317791, 16163393, 21546913, 21969594, 22226636, 27749819; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent Clp protease proteolytic subunit; Maxwell's demon" /protein_id="NP_391334.1" /db_xref="EnsemblGenomes-Gn:BSU34540" /db_xref="EnsemblGenomes-Tr:CAB15459" /db_xref="GOA:P80244" /db_xref="InterPro:IPR001907" /db_xref="InterPro:IPR018215" /db_xref="InterPro:IPR023562" /db_xref="InterPro:IPR029045" /db_xref="InterPro:IPR033135" /db_xref="PDB:3KTG" /db_xref="PDB:3KTH" /db_xref="PDB:3KTI" /db_xref="PDB:3KTJ" /db_xref="PDB:3KTK" /db_xref="PDB:3TT6" /db_xref="PDB:3TT7" /db_xref="SubtiList:BG19016" /db_xref="UniProtKB/Swiss-Prot:P80244" /translation="MNLIPTVIEQTNRGERAYDIYSRLLKDRIIMLGSAIDDNVANSI VSQLLFLAAEDPEKEISLYINSPGGSITAGMAIYDTMQFIKPKVSTICIGMAASMGAF LLAAGEKGKRYALPNSEVMIHQPLGGAQGQATEIEIAAKRILLLRDKLNKVLAERTGQ PLEVIERDTDRDNFKSAEEALEYGLIDKILTHTEDKK*" /label="clpP CDS" gene 3197348..3197941 /gene="clpP" /locus_tag="BSU_34540" /old_locus_tag="BSU34540" /label="clpP gene" downshifts 3197930 /Source="Nicolas_upshifts" /id="D1790" /incds=0 /nref=292 /ntot=300 /MaxReadThrough="4.45406" /MaxDrop="8.24306" /score="30.2626808" /energy="-14.6" /TU="U2714" /idTUdmin="U2715" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" S_feature 3197975..3198373 /Source="Nicolas_S_feature" /locus_tag="new_3546861_3547259" /HighExp="Etha, dia15, Heat, LoTm, M9-stat, Gly, dia5, Diami, S8, H2O2" /AntisenseName="pgcM" /AntisenseCor="0.13310786898312499" /AntisenseRegPval="-1.5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1319" CDS complement(3197987..3198667) /gene="mdxM" /locus_tag="BSU_34550" /old_locus_tag="BSU34550" /EC_number="2.7.1.41" /EC_number="5.4.2.6" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:4275311, 11081794, 15996095" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4275311, 11081794, 15996095; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional beta-phosphoglucomutase / glucose-1-phosphate phosphodismutase" /protein_id="NP_391335.1" /db_xref="EnsemblGenomes-Gn:BSU34550" /db_xref="EnsemblGenomes-Tr:CAB15460" /db_xref="GOA:O06995" /db_xref="InterPro:IPR006439" /db_xref="InterPro:IPR010972" /db_xref="InterPro:IPR010976" /db_xref="InterPro:IPR023198" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="PDB:3NAS" /db_xref="SubtiList:BG12422" /db_xref="UniProtKB/Swiss-Prot:O06995" /translation="MKAVIFDLDGVITDTAEYHFLAWKHIAEQIDIPFDRDMNERLKG ISREESLESILIFGGAETKYTNAEKQELMHRKNRDYQMLISKLTPEDLLPGIGRLLCQ LKNENIKIGLASSSRNAPKILRRLAIIDDFHAIVDPTTLAKGKPDPDIFLTAAAMLDV SPADCAAIEDAEAGISAIKSAGMFAVGVGQGQPMLGADLVVRQTSDLTLELLHEEWEQ YRIRESIP*" /label="mdxM CDS" gene complement(3197987..3198667) /gene="mdxM" /locus_tag="BSU_34550" /old_locus_tag="BSU34550" /label="mdxM gene" downshifts complement(3198011) /Source="Nicolas_upshifts" /id="D1791" /incds=0 /nref=2 /ntot=36 /MaxReadThrough="3.4944" /MaxDrop="3.50516" /score="-9.43329271" /energy="-14.6" /TU="U2718" /idTUdmin="U2718" /TUdmin="-506" /isTUend="FALSE" /label="downshifts" CDS complement(3198664..3200349) /gene="mdxL" /locus_tag="BSU_34560" /old_locus_tag="BSU34560" /EC_number="3.2.1.10" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9573215, 10229946, 1670768" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9573215, 10229946, 1670768; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="oligo-1,4-1,6-alpha-glucosidase (sucrase-maltase-isomaltase)" /protein_id="NP_391336.1" /db_xref="EnsemblGenomes-Gn:BSU34560" /db_xref="EnsemblGenomes-Tr:CAB15461" /db_xref="GOA:O06994" /db_xref="InterPro:IPR006047" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR032091" /db_xref="PDB:4M56" /db_xref="PDB:4M8U" /db_xref="PDB:4MAZ" /db_xref="PDB:4MB1" /db_xref="SubtiList:BG12421" /db_xref="UniProtKB/Swiss-Prot:O06994" /translation="MSEWWKEAVVYQIYPRSFYDANGDGFGDLQGVIQKLDYIKNLGA DVIWLSPVFDSPQDDNGYDISDYKNMYEKFGTNEDMFQLIDEVHKRGMKIVMDLVVNH TSDEHAWFAESRKSKDNPYRDYYLWKDPKPDGSEPNNWGSIFSGSAWTYDEGTGQYYL HYFSKKQPDLNWENEAVRREVYDVMRFWMDRGVDGWRMDVIGSISKYTDFPDYETDHS RSYIVGRYHSNGPRLHEFIQEMNREVLSHYDCMTVGEANGSDIEEAKKYTDASRQELN MIFTFEHMDIDKEQNSPNGKWQIKPFDLIALKKTMTRWQTGLMNVGWNTLYFENHDQP RVISRWGNDRKLRKECAKAFATVLHGMKGTPFIYQGEEIGMVNSDMPLEMYDDLEIKN AYRELVVENKTMSEKEFVKAVMIKGRDHARTPMQWDAGKHAGFTAGDPWIPVNSRYQD INVKESLEDQDSIFFYYQKLIQLRKQYKIMIYGDYQLLQENDPQVFSYLREYRGEKLL VVVNLSEEKALFEAPPELIHERWKVLISNYPQERADLKSISLKPYEAVMGISI*" /label="mdxL CDS" gene complement(3198664..3200349) /gene="mdxL" /locus_tag="BSU_34560" /old_locus_tag="BSU34560" /label="mdxL gene" CDS complement(3200342..3202615) /gene="mdxK" /locus_tag="BSU_34570" /old_locus_tag="BSU34570" /EC_number="2.4.1.8" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16707683, 28527120" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16707683, 28527120; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="maltose phosphorylase" /protein_id="NP_391337.1" /db_xref="EnsemblGenomes-Gn:BSU34570" /db_xref="EnsemblGenomes-Tr:CAB15462" /db_xref="GOA:O06993" /db_xref="InterPro:IPR005194" /db_xref="InterPro:IPR005195" /db_xref="InterPro:IPR005196" /db_xref="InterPro:IPR008928" /db_xref="InterPro:IPR011013" /db_xref="InterPro:IPR017045" /db_xref="SubtiList:BG12420" /db_xref="UniProtKB/Swiss-Prot:O06993" /translation="MINQRLFEIDEWKIKTNTFNKEHTRLLESLTSLANGYMGVRGNF EEGYSGDSHQGTYIAGVWFPDKTRVGWWKNGYPEYFGKVINAMNFMGIGLYVDGEKID LHQNPIELFEVELNMKEGILRRSAVVRIQDKTVRIRSERFLSLAVKELCAIHYEAECL TGDAVITLVPYLDGNVANEDSNYQEQFWQEEAKGADSHSGHLAAKTIENPFGTPRFTV LAAMANETEGFVHESFKTTEMYVENRYSYQTKASLKKFVIVTTSRDFREEELLSKAKE LLADVVENGYEDAKRRHTDRWKERWAKADIEIKGDEELQQGIRYNIFQLFSTYYGGDA RLNIGPKGFTGEKYGGAAYWDTEAYAVPMYLATAEPEVTKNLLLYRYHQLEAAKRNAA KLGMKGALYPMVTFTGDECHNEWEITFEEIHRNGAICYAIYNYINYTGDRNYMEEYGI DVLVAVSRFWADRVHFSKRKNKYMIHGVTGPNEYENNVNNNWYTNVIAAWTLEYTLQS LESISAEKRRHLDVQEVELEVWREIIQHMYYPFSEELQIFVQHDTFLDKDLQTVDELD PAERPLYQNWSWDKILRSNFIKQADVLQGIYLFNDRFTMEEKRRNFEFYEPMTVHESS LSPSVHAILAAELKLEKKALELYKRTARLDLDNYNHDTEEGLHITSMTGSWLAIVHGF AGMRTANETLSFAPFLPKEWDEYSFNINYRNRLINVTVDEKRVIFELVKGEPLHMNVY EEPVVLQGRCERRTPNE*" /label="mdxK CDS" gene complement(3200342..3202615) /gene="mdxK" /locus_tag="BSU_34570" /old_locus_tag="BSU34570" /label="mdxK gene" CDS complement(3202593..3203477) /gene="mdxJ" /locus_tag="BSU_34580" /old_locus_tag="BSU34580" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16707683, 16850406, 20436965; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative component of maltodextrin transporter" /protein_id="NP_391338.1" /db_xref="EnsemblGenomes-Gn:BSU34580" /db_xref="EnsemblGenomes-Tr:CAB15463" /db_xref="GOA:O06992" /db_xref="InterPro:IPR009574" /db_xref="SubtiList:BG12419" /db_xref="UniProtKB/Swiss-Prot:O06992" /translation="MKNLENKSFIIRCLKAAASPSGVCRYGNTFSWLQLSFLFLFLTA CLMAPLAVSFVKMDRFSVSSFMPSAIQGVNDQFADQLQGFQIRNGKLTGGKSSERIED GQNVMAVDMKHEYETSGENGRLKVTGFENAIIFQPDQLVITDQNETGFSVGYAKMDVK LEKPNVHDVEVLIDTLWLAQYKPMIMMLAYTVVSMIQLLLTFVLAGGLWITKISNMVS IASFKEAASIAICASALPAFAAAAIGMVHFDLITVLMIHSCGVTLMISFAFRYLTKTR RDNGNLHSGGNDDKSAVI*" /label="mdxJ CDS" gene complement(3202593..3203477) /gene="mdxJ" /locus_tag="BSU_34580" /old_locus_tag="BSU34580" /label="mdxJ gene" CDS complement(3203483..3204319) /gene="mdxG" /locus_tag="BSU_34590" /old_locus_tag="BSU34590" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16707683, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16707683, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="maltodextrin ABC transporter (permease)" /protein_id="NP_391339.1" /db_xref="EnsemblGenomes-Gn:BSU34590" /db_xref="EnsemblGenomes-Tr:CAB15464" /db_xref="GOA:O06991" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12418" /db_xref="UniProtKB/Swiss-Prot:O06991" /translation="MNASTARMLNKICTYLFLTLLSIVIIYPLLITASSAFRVGNSAA FQLDFSGSWTLDHFKRLFDETLYLNWYSNTLVIALSVMVLQVTIVTLAGYSYSRYRFA GRKKSLIFFLIIQMVPTMAALTAFYVLAMLIGALDQYWFLTAIYIGGGIPMNTWLMKG YFDTVPREIDEAARIDGAGHLRIFASIVLPLVKPMLAVQALWAFMAPFGDYLLTKFLL RSPERLTIAVGLQSFISNPQQQKVALFAAGAILAALPICVLFFFLQKNFVSGLTAGGT KG*" /label="mdxG CDS" gene complement(3203483..3204319) /gene="mdxG" /locus_tag="BSU_34590" /old_locus_tag="BSU34590" /label="mdxG gene" CDS complement(3204320..3205627) /gene="mdxF" /locus_tag="BSU_34600" /old_locus_tag="BSU34600" /experiment="publication(s) with functional evidences, PMID:15849754, 16707683, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16707683, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="maltodextrin ABC transport system (permease)" /protein_id="NP_391340.1" /db_xref="EnsemblGenomes-Gn:BSU34600" /db_xref="EnsemblGenomes-Tr:CAB15465" /db_xref="GOA:O06990" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR035277" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG12417" /db_xref="UniProtKB/Swiss-Prot:O06990" /translation="MNKHHTLTKQKRKAGLLSIIPGLGQIANQQLSKGLLFLAITGLF AFELCVFGIQALTGLMTLGSVPGEDHSLFMLIEGTLQLIVTMIFLMFYIFNIHDSRKT AAMKAAGLEVNTTAKDMICHAGDKGFPYLFTLPAYIMMVFVIIFPVLVTLFVALTNYD FYHIPPNRLIDWVGFKNFLNIFFLGSYRETFVNVLGWTVIWTICATTLQIILGIVTAL FVNQDFIKGKRIFRMIFLFPWAVPAFITIMSFSNMFNDSIGAVNAQVIPLFNHLPFVE LPAIAWKTDPFWTKTALIMIQTWLGFPYIYVMVTGVLQAIPGELYEAAKIDGATFIQR FRHITFPMILFATAPVMITQYTFNFNNFSIIYLFNEGGPGSAGAGAGSTDILISWIYK LTTGTSPQYSVAAAVTLLISFIVIGISLIAFKKSNAFGNEEVM*" /label="mdxF CDS" gene complement(3204320..3205627) /gene="mdxF" /locus_tag="BSU_34600" /old_locus_tag="BSU34600" /label="mdxF gene" promotor_-35 3204685..3204694 /Source="Nicolas_upshift_promotors" /id="U2716" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1371 /SigmaFactorBS="atctttgccgcttcatacaattcacctggaatcgCCTGAAGC ACtcccgttaccatGACATATATATATGGAAAGCcgagccacgtttgaatcataatga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3204707..3204726 /Source="Nicolas_upshift_promotors" /id="U2716" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1371 /SigmaFactorBS="atctttgccgcttcatacaattcacctggaatcgCCTGAAGC ACtcccgttaccatGACATATATATATGGAAAGCcgagccacgtttgaatcataatga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3204711 /Source="Nicolas_upshifts" /id="U2716" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=1371 /SigmaFactorBS="atctttgccgcttcatacaattcacctggaatcgCCTGAAGC ACtcccgttaccatGACATATATATATGGAAAGCcgagccacgtttgaatcataatga g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3205667..3206920) /gene="mdxE" /locus_tag="BSU_34610" /old_locus_tag="BSU34610" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16707683" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16707683; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="maltose/maltodextrin-binding lipoprotein" /protein_id="NP_391341.1" /db_xref="EnsemblGenomes-Gn:BSU34610" /db_xref="EnsemblGenomes-Tr:CAB15466" /db_xref="GOA:O06989" /db_xref="InterPro:IPR006060" /db_xref="SubtiList:BG12416" /db_xref="UniProtKB/Swiss-Prot:O06989" /translation="MVLLKKGFAILAASFLAIGLAACSSSKNPASSDGKKVLTVSVEE TYKEYIESIKTKFEKENDVTVKIVEKQMFEQLEALPLDGPAGNAPDVMLAAYDRIGGL GQQGHLLDIKPSNTKSFGDKEMQQVTVDGKVYGMPLVIETLILYYNKDLLKTAPKTFK DLEKLTEDPRFAFASEKGKSTGFLAKWTDFYMSYGLLAGYGGYVFGKNGTDSGDIGLN NKGAVEAVKYAEKWFETYWPKGMQDNSSADDFIQQMFLEGKAAAIIGGPWSAANYKEA KLNYGAAPIPTLPNGEEYAPFAGGKGWVASKYTKEPELAEKWLEYAANDANAYAFYED TNEVPANTAARKKADEQKNELTSAVIKQYETATPTPNIPEMAEVWTGAESLIFDAASG KKSTQTSANDAVNVIKENIKEKYVK*" /label="mdxE CDS" gene complement(3205667..3206920) /gene="mdxE" /locus_tag="BSU_34610" /old_locus_tag="BSU34610" /label="mdxE gene" S_feature complement(3206921..3207015) /Source="Nicolas_S_feature" /locus_tag="new_3555807_3555901_c" /HighExp="T1.0H, T0.30H, BC, T1.30H, M40t90, M0t90, BI, B60, S8, M9-stat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.804" /TUlongSig="NA" /TUlongPSig="NA" /label="S1320" CDS complement(3207016..3208785) /gene="mdxD" /locus_tag="BSU_34620" /old_locus_tag="BSU34620" /EC_number="3.2.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10825545, 15650689, 16707683, 19465663, 27871383, 27871383" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10825545, 15650689, 16707683, 19465663, 27871383, 27871383; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="maltogenic alpha-amylase" /protein_id="NP_391342.1" /db_xref="EnsemblGenomes-Gn:BSU34620" /db_xref="EnsemblGenomes-Tr:CAB15467" /db_xref="GOA:O06988" /db_xref="InterPro:IPR004185" /db_xref="InterPro:IPR006047" /db_xref="InterPro:IPR013777" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR017853" /db_xref="SubtiList:BG12415" /db_xref="UniProtKB/Swiss-Prot:O06988" /translation="MMEYAAIHHQPFSTDAYSYDGRTVHIKIRTKKGDADHIRFIWGD PYEYNDGKWSANEQPMRKIAATEMHDYWFAEVVPPFRRLQYAFVVTDDHEDIFFGSSG VCPYNEKTLETIHYYFKFPFVHEADTFQAPEWVKSTVWYQIFPERFANGREDLSPKNA LPWGSKDPDVNDFFGGDLQGIVDKLDYLEDLGVNGIYLTPIFSAPSNHKYDTLDYFSI DPHFGDPELFRTLVSQLHQRGMRIMLDAVFNHIGSASPQWQDVVKNGDQSRYKDWFHI HSFPVTDDNYDRFAFTADMPKLNTANPEVQKYLLDIALYWIREFDIDGWRLDVANEVD HVFWKTFRQAVSTEKPDVYILGEIWHSAEPWLRGDEFHAAMNYPFTEPMIEYFADQTI SASRMAHRVNAHLMNGMKQANEVMFNLLDSHDTKRLLTRCRNDEKKARALLAFMFAQT GSPCIYYGTEIGLNGENDPLCRKCMVWEKEKQNQDMLQFMKRLIALRKQENTLLTEGH LEWNLLDDKNDFISFSRTLDEKILIYFFNQGNVVQHVSLRELNIDRNKKICDAWTEQP LQHHDVIAVQPGEFLILSAAAPV*" /label="mdxD CDS" gene complement(3207016..3208785) /gene="mdxD" /locus_tag="BSU_34620" /old_locus_tag="BSU34620" /label="mdxD gene" promotor_-35 3208706..3208711 /Source="Nicolas_upshift_promotors" /id="U2717" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1040 /SigmaFactorBS="gatctgcatcaccttttttcgtccgaatcTTGATAtgcacag tccgcccaTCATAAGAATAAGCATCTGtgctgaatggctggtgatgaatcgctgcata t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3208727..3208745 /Source="Nicolas_upshift_promotors" /id="U2717" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1040 /SigmaFactorBS="gatctgcatcaccttttttcgtccgaatcTTGATAtgcacag tccgcccaTCATAAGAATAAGCATCTGtgctgaatggctggtgatgaatcgctgcata t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3208737 /Source="Nicolas_upshifts" /id="U2717" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.957042957042957" /psig="0.957042957042957" /xcortree=1040 /SigmaFactorBS="gatctgcatcaccttttttcgtccgaatcTTGATAtgcacag tccgcccaTCATAAGAATAAGCATCTGtgctgaatggctggtgatgaatcgctgcata t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3208823..3208842) /Source="Nicolas_upshift_promotors" /id="U2718" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.538461538461538" /psig="0.804195804195804" /xcortree=343 /SigmaFactorBS="cgccttattctgttatcggtaacagggtgaaaagGATTGTTC ccacaatttcatCATGATACTTTCAAACTATGagccggcttcaataaaacggaaatca a" /listShort="mdxD, S1320, mdxE, mdxF, mdxG, yvdJ, malK, malL, pgcM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3208836) /Source="Nicolas_upshifts" /id="U2718" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.538461538461538" /psig="0.804195804195804" /xcortree=343 /SigmaFactorBS="cgccttattctgttatcggtaacagggtgaaaagGATTGTTC ccacaatttcatCATGATACTTTCAAACTATGagccggcttcaataaaacggaaatca a" /listShort="mdxD, S1320, mdxE, mdxF, mdxG, yvdJ, malK, malL, pgcM" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3208855..3208862) /Source="Nicolas_upshift_promotors" /id="U2718" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.538461538461538" /psig="0.804195804195804" /xcortree=343 /SigmaFactorBS="cgccttattctgttatcggtaacagggtgaaaagGATTGTTC ccacaatttcatCATGATACTTTCAAACTATGagccggcttcaataaaacggaaatca a" /listShort="mdxD, S1320, mdxE, mdxF, mdxG, yvdJ, malK, malL, pgcM" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3208898..3209848) /gene="mdxR" /locus_tag="BSU_34630" /old_locus_tag="BSU34630" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16707683, 23951303" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16707683, 23951303; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional activator of the maltodextrin operon (LacI family)" /protein_id="NP_391343.1" /db_xref="EnsemblGenomes-Gn:BSU34630" /db_xref="EnsemblGenomes-Tr:CAB15468" /db_xref="GOA:O06987" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG12414" /db_xref="UniProtKB/Swiss-Prot:O06987" /translation="MATLSDVAKKANVSKMTVSRVINHPETVTDELKKLVHSAMKELN YIPNYAARALVQNRTQVVKLLILEEMDTTEPYYMNLLTGISRELDRNHYALQLVTRNS LNIGQCDGIIATGLRKNDFEGVIKAFEKPLVVFGQNEMGYDFIDVNNEKGTFMATRHV MGLGEREVVFFGIDLDEPFERAREQGYIRAMNKSFKKSNMFRIDNSSKKSECLARELL KSMDNQAAFVCASDRIALGVIRAAQSLGKRIPEDVAVTGNDGVFLDRISSPRLTTVRQ PVVEMGEACAKMLLKKMNEDGAAQGSLFFEPELIVRESTL*" /label="mdxR CDS" gene complement(3208898..3209848) /gene="mdxR" /locus_tag="BSU_34630" /old_locus_tag="BSU34630" /label="mdxR gene" promotor_-10 complement(3209863..3209881) /Source="Nicolas_upshift_promotors" /id="U2719" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.98101898101898" /psig="0.98101898101898" /xcortree=516 /SigmaFactorBS="ttctctttggcctgcatcgtatatttagcagtaatAGAGGAC TTtatcactagttTGGATAATAAGCACAGATAaggaggggatgaaaatggcaacattg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3209876) /Source="Nicolas_upshifts" /id="U2719" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.98101898101898" /psig="0.98101898101898" /xcortree=516 /SigmaFactorBS="ttctctttggcctgcatcgtatatttagcagtaatAGAGGAC TTtatcactagttTGGATAATAAGCACAGATAaggaggggatgaaaatggcaacattg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3209893..3209901) /Source="Nicolas_upshift_promotors" /id="U2719" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.98101898101898" /psig="0.98101898101898" /xcortree=516 /SigmaFactorBS="ttctctttggcctgcatcgtatatttagcagtaatAGAGGAC TTtatcactagttTGGATAATAAGCACAGATAaggaggggatgaaaatggcaacattg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3209982) /Source="Nicolas_upshifts" /id="D1792" /incds=0 /nref=134 /ntot=243 /MaxReadThrough="0.22626" /MaxDrop="5.17193" /score="21.4455132" /energy="-10" /TU="NA" /idTUdmin="U2720" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" CDS complement(3210054..3210629) /gene="yvdD" /locus_tag="BSU_34640" /old_locus_tag="BSU34640" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_391344.1" /db_xref="EnsemblGenomes-Gn:BSU34640" /db_xref="EnsemblGenomes-Tr:CAB15469" /db_xref="InterPro:IPR005269" /db_xref="InterPro:IPR031100" /db_xref="PDB:1T35" /db_xref="SubtiList:BG12413" /db_xref="UniProtKB/Swiss-Prot:O06986" /translation="MKTICVFAGSNPGGNEAYKRKAAELGVYMAEQGIGLVYGGSRVG LMGTIADAIMENGGTAIGVMPSGLFSGEVVHQNLTELIEVNGMHERKAKMSELADGFI SMPGGFGTYEELFEVLCWAQIGIHQKPIGLYNVNGYFEPMMKMVKYSIQEGFSNESHL KLIHSSSRPDELIEQMQNYSYPILEKKWTEI*" /label="yvdD CDS" gene complement(3210054..3210629) /gene="yvdD" /locus_tag="BSU_34640" /old_locus_tag="BSU34640" /label="yvdD gene" downshifts complement(3210066) /Source="Nicolas_upshifts" /id="D1793" /incds=0 /nref=30 /ntot=209 /MaxReadThrough="4.23893" /MaxDrop="3.6086" /score="21.4455132" /energy="-10" /TU="U2720" /idTUdmin="U2720" /TUdmin="-87" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3210672..3210691) /Source="Nicolas_upshift_promotors" /id="U2720" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.61038961038961" /psig="0.998001998001998" /xcortree=3064 /SigmaFactorBS="caacctcatcactcctgcattctttatgtatttcaTATTGAT AttatcacatgaagaTGGGACAATATATAGTGTGTttttgaatgtttaacacgatata t" /listShort="yvdD" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 3210678..3210685 /Source="Nicolas_upshift_promotors" /id="U2721" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.856143856143856" /psig="0.998001998001998" /xcortree=3065 /SigmaFactorBS="catctccgcatctatatatcgtgttaaacattcaaaaacaca cTATATATTgtcccatcttcaTGTGATAATATCAATATGAAatacataaagaatgcag g" /listShort="yvdC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3210688) /Source="Nicolas_upshifts" /id="U2720" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.61038961038961" /psig="0.998001998001998" /xcortree=3064 /SigmaFactorBS="caacctcatcactcctgcattctttatgtatttcaTATTGAT AttatcacatgaagaTGGGACAATATATAGTGTGTttttgaatgtttaacacgatata t" /listShort="yvdD" /GFF_Attribute="listLong" /label="upshifts" upshifts 3210695 /Source="Nicolas_upshifts" /id="U2721" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.856143856143856" /psig="0.998001998001998" /xcortree=3065 /SigmaFactorBS="catctccgcatctatatatcgtgttaaacattcaaaaacaca cTATATATTgtcccatcttcaTGTGATAATATCAATATGAAatacataaagaatgcag g" /listShort="yvdC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3210698..3210717 /Source="Nicolas_upshift_promotors" /id="U2721" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.856143856143856" /psig="0.998001998001998" /xcortree=3065 /SigmaFactorBS="catctccgcatctatatatcgtgttaaacattcaaaaacaca cTATATATTgtcccatcttcaTGTGATAATATCAATATGAAatacataaagaatgcag g" /listShort="yvdC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3210706..3210713) /Source="Nicolas_upshift_promotors" /id="U2720" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.61038961038961" /psig="0.998001998001998" /xcortree=3064 /SigmaFactorBS="caacctcatcactcctgcattctttatgtatttcaTATTGAT AttatcacatgaagaTGGGACAATATATAGTGTGTttttgaatgtttaacacgatata t" /listShort="yvdD" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3210746..3211066 /gene="yvdC" /locus_tag="BSU_34650" /old_locus_tag="BSU34650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16120674, 19684115; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative pyrophosphohydrolase" /protein_id="NP_391345.1" /db_xref="EnsemblGenomes-Gn:BSU34650" /db_xref="EnsemblGenomes-Tr:CAB15470" /db_xref="InterPro:IPR004518" /db_xref="InterPro:IPR011411" /db_xref="SubtiList:BG12412" /db_xref="UniProtKB/Swiss-Prot:O32263" /translation="MQLADAEKWMKEFYEKRGWTEYGPFIRVGFLMEEAGELARAVRA YEIGRDRPDEKESSRAEQKQELIEEMGDVIGNIAILADMYGVSLEDVMKAHQEKLTKR FEHA*" /label="yvdC CDS" gene 3210746..3211066 /gene="yvdC" /locus_tag="BSU_34650" /old_locus_tag="BSU34650" /label="yvdC gene" downshifts 3211047 /Source="Nicolas_upshifts" /id="D1794" /incds=0 /nref=134 /ntot=247 /MaxReadThrough="2.19085" /MaxDrop="5.46819" /score="35.8658106" /energy="-11.6" /TU="NA" /idTUdmin="U2721" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(3211093) /Source="Nicolas_upshifts" /id="D1795" /incds=0 /nref=13 /ntot=56 /MaxReadThrough="0.462300000000001" /MaxDrop="6.90114" /score="30.4681035" /energy="-11.3" /TU="NA" /idTUdmin="U2722" /TUdmin=8 /isTUend="TRUE" /label="downshifts" CDS complement(3211093..3212685) /gene="yvdB" /locus_tag="BSU_34660" /old_locus_tag="BSU34660" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative anion transporter" /protein_id="NP_391346.1" /db_xref="EnsemblGenomes-Gn:BSU34660" /db_xref="EnsemblGenomes-Tr:CAB15471" /db_xref="GOA:O06984" /db_xref="InterPro:IPR001902" /db_xref="InterPro:IPR002645" /db_xref="InterPro:IPR011547" /db_xref="InterPro:IPR036513" /db_xref="SubtiList:BG12411" /db_xref="UniProtKB/Swiss-Prot:O06984" /translation="MRFSGRFKGYNLQKFQKDLIAGIVVGVVAIPLGMAFAIASGVEP EYGLYTVVIAGICISLFGGSKYQIGGPTGAFVPILFGIIMQYGLENLLIAGFMAGVML VLFGLFKLGKIMKFVPKPVIVGFTAGIAVLIFTEQIANFLGLRNVEKHENFHHNMFEI VQQLGTFNVYAILTAVIGLVILLVSAKVMPKVPGALLALLISTVVAVVFFPDRMATIG STYGEIPRHLPEFQFPELTLDKMVMLFPAALVIALLGGLESILSAMVADNMKGSKHDS NKELVGQGIANMAAPLFGGIPATGAIARTATNIKNGAVSPVSGVVHGVVVLLVLLVFA PYASHVPLASMAPILMVVAWNMSERKEVANMLRLKNADSFILAATFALTVLFDLIIGV ATGLLLAFVFFIRRMSEATRIHNQETHPVLAKREDPSVSMYAIEGPLFFGSIDSLESS LLEHVQKKPKTLILLMNKVHYMDTSAEAVLGNIMNRIKRHNGKLMIVGLQSQPKELLH KTGLFHKIGKQHFFDHHDEITG*" /label="yvdB CDS" gene complement(3211093..3212685) /gene="yvdB" /locus_tag="BSU_34660" /old_locus_tag="BSU34660" /label="yvdB gene" CDS complement(3212704..3213297) /gene="yvdA" /locus_tag="BSU_34670" /old_locus_tag="BSU34670" /EC_number="4.2.1.1" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10611359; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative carbonic anhydrase" /protein_id="NP_391347.1" /db_xref="EnsemblGenomes-Gn:BSU34670" /db_xref="EnsemblGenomes-Tr:CAB15472" /db_xref="GOA:O06983" /db_xref="InterPro:IPR001765" /db_xref="InterPro:IPR036874" /db_xref="SubtiList:BG12410" /db_xref="UniProtKB/Swiss-Prot:O06983" /translation="MNQMVSLTSILEHNQRFVSEKKYEPYKTTKFPSKKLVIVTCMDT RLTELLPQAMGLKNGDAKIVKNAGAIVSHPFGSVMRSILVAIYELQAEEVCIVGHHEC GMSGLNASSILEKAKERGVEDSCLNLLTSAGLDLKTWLTGFHSVEESVSHSVNMIKNH PLLPKKVPVHGLVIHPETGKLDVVINGYETELINNHS*" /label="yvdA CDS" gene complement(3212704..3213297) /gene="yvdA" /locus_tag="BSU_34670" /old_locus_tag="BSU34670" /label="yvdA gene" promotor_-10 complement(3213339..3213358) /Source="Nicolas_upshift_promotors" /id="U2722" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.38961038961039" /psig="0.98901098901099" /xcortree=371 /SigmaFactorBS="ttctacagtccaattatagtgtctttttttgaaaaCCTTTtc ttggcttattccTATGCTATAATTCCTTACTGtaagctgggtaagaaggcttgcaaaa t" /listShort="yvdA, yvdB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3213352) /Source="Nicolas_upshifts" /id="U2722" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.38961038961039" /psig="0.98901098901099" /xcortree=371 /SigmaFactorBS="ttctacagtccaattatagtgtctttttttgaaaaCCTTTtc ttggcttattccTATGCTATAATTCCTTACTGtaagctgggtaagaaggcttgcaaaa t" /listShort="yvdA, yvdB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3213373..3213377) /Source="Nicolas_upshift_promotors" /id="U2722" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.38961038961039" /psig="0.98901098901099" /xcortree=371 /SigmaFactorBS="ttctacagtccaattatagtgtctttttttgaaaaCCTTTtc ttggcttattccTATGCTATAATTCCTTACTGtaagctgggtaagaaggcttgcaaaa t" /listShort="yvdA, yvdB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3213423..3213428 /Source="Nicolas_upshift_promotors" /id="U2723" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.934065934065934" /psig="0.934065934065934" /xcortree=962 /SigmaFactorBS="aaaaagacactataattggactgtagaatcaaaacataAACA TTtatatctttcaaagaTAATAAAATTTATATTTAAtgcatcctataatccggctgca g" /listShort="yvcT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3213444..3213462 /Source="Nicolas_upshift_promotors" /id="U2723" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.934065934065934" /psig="0.934065934065934" /xcortree=962 /SigmaFactorBS="aaaaagacactataattggactgtagaatcaaaacataAACA TTtatatctttcaaagaTAATAAAATTTATATTTAAtgcatcctataatccggctgca g" /listShort="yvcT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3213445 /Source="Nicolas_upshifts" /id="U2723" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.934065934065934" /psig="0.934065934065934" /xcortree=962 /SigmaFactorBS="aaaaagacactataattggactgtagaatcaaaacataAACA TTtatatctttcaaagaTAATAAAATTTATATTTAAtgcatcctataatccggctgca g" /listShort="yvcT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3213618..3213625 /Source="Nicolas_upshift_promotors" /id="U2724" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74025974025974" /psig=1 /xcortree=1931 /SigmaFactorBS="gttcaaaagaaccagaaattaaaaaaacgcagctaTATTTTT AacatctatttattTTCGATATAATGAATTAGACaacagccataaagggggagccttg t" /listShort="yvcT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3213639..3213658 /Source="Nicolas_upshift_promotors" /id="U2724" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74025974025974" /psig=1 /xcortree=1931 /SigmaFactorBS="gttcaaaagaaccagaaattaaaaaaacgcagctaTATTTTT AacatctatttattTTCGATATAATGAATTAGACaacagccataaagggggagccttg t" /listShort="yvcT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3213643 /Source="Nicolas_upshifts" /id="U2724" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74025974025974" /psig=1 /xcortree=1931 /SigmaFactorBS="gttcaaaagaaccagaaattaaaaaaacgcagctaTATTTTT AacatctatttattTTCGATATAATGAATTAGACaacagccataaagggggagccttg t" /listShort="yvcT" /GFF_Attribute="listLong" /label="upshifts" CDS 3213680..3214657 /gene="yvcT" /locus_tag="BSU_34680" /old_locus_tag="BSU34680" /EC_number="1.1.1.215" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9811658, 25769838; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative 2-ketogluconate reductase; hydroxypyruvate / glyoxylate reductase" /protein_id="NP_391348.1" /db_xref="EnsemblGenomes-Gn:BSU34680" /db_xref="EnsemblGenomes-Tr:CAB15473" /db_xref="GOA:O32264" /db_xref="InterPro:IPR006139" /db_xref="InterPro:IPR006140" /db_xref="InterPro:IPR029752" /db_xref="InterPro:IPR029753" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12409" /db_xref="UniProtKB/Swiss-Prot:O32264" /translation="MLKPFVFITKPIPEEIEAFIGEHCRYEVWQEDTLPSDVLFEKLK EAEGLLTSGTSGPSINRELLEHAPKLKVVSNQSVGYDNFDIEAMKERGVVGTHTPYTL DDTVADLAFSLILSSARRVAELDRFVRAGKWGTVEEEALFGIDVHHQTLGIIGMGRIG EQAARRAKFGFDMEVLYHNRHRKQETEDSIGVKYAELDTLLEQSDFILLITPLTDETY HMIGEREFKLMKNSAIFVNISRGKTVDEKALIRALQEGWIRGAGLDVYEKEPVTQDNP LLQLDNVTLLPHIGSATAKVRFNMCKQAAENMLAAIQGQTPKNLTREFQ*" /label="yvcT CDS" gene 3213680..3214657 /gene="yvcT" /locus_tag="BSU_34680" /old_locus_tag="BSU34680" /label="yvcT gene" downshifts 3214629 /Source="Nicolas_upshifts" /id="D1796" /incds=0 /nref=223 /ntot=269 /MaxReadThrough="2.44036" /MaxDrop="5.93476" /score="1.05732532" /energy="-14.7" /TU="NA" /idTUdmin="U2724" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS complement(3214695..3216635) /gene="psdB" /locus_tag="BSU_34690" /old_locus_tag="BSU34690" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 21078927, 27997719" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 21078927, 27997719; Product type t: transporter" /codon_start=1 /transl_table=11 /product="lantibiotic ABC transporter (permease)" /protein_id="NP_391349.1" /db_xref="EnsemblGenomes-Gn:BSU34690" /db_xref="EnsemblGenomes-Tr:CAB15474" /db_xref="GOA:O06981" /db_xref="InterPro:IPR003838" /db_xref="InterPro:IPR027022" /db_xref="SubtiList:BG12408" /db_xref="UniProtKB/Swiss-Prot:O06981" /translation="MNLRTIARKNILGNLQRYVAYFLSCVFAVSVFFVFTSFIFHPDV NEDNIYGGSLVKTCLSAALVVIIVFCIFFITYSNSAFLQARKKEFGLLTLFGTSKQQL RKMIYYEQSLISLAAIAAGIGAGLLFSKLFFMIMTWMLSVKVPISFAIVPKAFVMTIA GFLILFQTLLILSLGRIRKLEIIELIKSAKKPKSLPVYSKWLTVLSLLCLGSGYYLSA TANAIDMMFRVFPILILVLIGTYFFFTQSSVAFFRMLYRKKHSFYKGTNIIVRSNMIF RLKDHARMLFLTSVITAVILTATGVIYMFYSDLQRQEEQSIPQSVSWVEKDASRFQVM KPETAENTLKKAHAVITYKVDATGIPVTFQSDLPYGNKKMEAEALLISEKVYNQVAKE KGFPVIHLQENEAFINVSFQMMVKDTFGEGETAAFHMKSGKTLSYVMKKQQNKGILMS VDGVSRLLVVSEKSFDSLSQDVPLKEQMRMVGYELEHWQETVDVSEKLENMVPKEHTS DFQTRAPSYQIVKQGVALMLFIGLFVSVLFFIVQGSMLYLRMFTEIEDTGVQVLALKR IGVTDKEIHSILGKQIGFLFFIPFIAGTIHAGFAYAALSNMLNSNLFLEAVIVIFIYF VFQALYYIVTRHIYKRAVLQRM*" /label="psdB CDS" gene complement(3214695..3216635) /gene="psdB" /locus_tag="BSU_34690" /old_locus_tag="BSU34690" /label="psdB gene" downshifts complement(3214719) /Source="Nicolas_upshifts" /id="D1797" /incds=0 /nref=11 /ntot=187 /MaxReadThrough="0.26118" /MaxDrop="4.59213" /score="26.9028733" /energy="-14.7" /TU="NA" /idTUdmin="U2725" /TUdmin=34 /isTUend="FALSE" /label="downshifts" CDS complement(3216610..3217389) /gene="psdA" /locus_tag="BSU_34700" /old_locus_tag="BSU34700" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12432961, 14651641, 21078927, 27997719" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12432961, 14651641, 21078927, 27997719; Product type t: transporter" /codon_start=1 /transl_table=11 /product="lantibiotic ABC transporter (ATP-binding protein)" /protein_id="NP_391350.1" /db_xref="EnsemblGenomes-Gn:BSU34700" /db_xref="EnsemblGenomes-Tr:CAB15475" /db_xref="GOA:O06980" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12407" /db_xref="UniProtKB/Swiss-Prot:O06980" /translation="MNVLQTTNLSKTYYSNKGTISYQALSAFDLSVSKGEFVGIMGPS GSGKTTLLNLLATIDKPTQGEMMINGIQPKTLKDQELALFRRRELGFVFQDFNLLDTL TIRENILLPLALDKVKLREMEARLDELADTLQIKHILDHRTYEVSGGQQQRAACARAI IHNPALILADEPTGNLDSKSAKQVMNTLAQLNEEKEATILLVTHDATAASFCKRIVFI KDGRFFSEIHRGTNRQVFYQSILDTLSVLGGDFHEFENYRP*" /label="psdA CDS" gene complement(3216610..3217389) /gene="psdA" /locus_tag="BSU_34700" /old_locus_tag="BSU34700" /label="psdA gene" S_feature complement(3217390..3217471) /Source="Nicolas_S_feature" /locus_tag="new_3566276_3566357_c" /HighExp="LBGtran, M0t45, H2O2, C30, Lbexp, Lbstat, LBGstat, dia0, Paraq, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 1, 0.997" /TUlongSig="SigA, SigA" /TUlongPSig="1, 0.999" /label="S1321" CDS complement(3217472..3218542) /gene="psdS" /locus_tag="BSU_34710" /old_locus_tag="BSU34710" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 12432961, 14651641, 21078927, 27997719" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 12432961, 14651641, 21078927, 27997719; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [PsdR] response to lantibiotics (nisin and gallidermin)" /protein_id="NP_391351.1" /db_xref="EnsemblGenomes-Gn:BSU34710" /db_xref="EnsemblGenomes-Tr:CAB15476" /db_xref="GOA:O06979" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12406" /db_xref="UniProtKB/Swiss-Prot:O06979" /translation="MLKTYLIDRLAIILFSLLGIGSAMLIAYLSIVESGAEPSKENMM YIWILPGTLLAAGFAADYVRQFSFLTYVKKLAEQASSSNDIGQSLKARKPRTGEQALW TKMINALGQQYESRLSQYINQQKQHYTFTNQWVHHMKTPVSVISLMIQEGKNGTSSSF PTFLEELEDENERFRHGLDMMLQTARLEEFAFDVKPQTFDLAEMVRSLINQEKRQFIK RRLFPTLHVPPNAVQISSDQKWLSFVVEQILFNALKYSKQGVGDPITIRIETQGHETR LSVADEGIGIPPQDLPRIFDAFFTGENGRTMKEATGMGLYLAKQVCSRLGHKLYAESK EGAGTVMTIVFSSDTLVNVTAL*" /label="psdS CDS" gene complement(3217472..3218542) /gene="psdS" /locus_tag="BSU_34710" /old_locus_tag="BSU34710" /label="psdS gene" CDS complement(3218536..3219249) /gene="psdR" /locus_tag="BSU_34720" /old_locus_tag="BSU34720" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 12432961, 14651641, 21078927, 27997719" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 12432961, 14651641, 21078927, 27997719; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [PsdS] responding to lipid II-binding lantibiotics (nisin and gallidermin)" /protein_id="NP_391352.1" /db_xref="EnsemblGenomes-Gn:BSU34720" /db_xref="EnsemblGenomes-Tr:CAB15477" /db_xref="GOA:O06978" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG12405" /db_xref="UniProtKB/Swiss-Prot:O06978" /translation="MYRILLVEDDERIASLLGGHLQKYGYEVKIAEQLNDIKLEFAEM KPDLVLLDINLPFFDGFYWCRQIRTISNAPIIFISARTDELNQVMAIENGGDDYITKP FHLEVVMAKIKSVLRRTYGEYSPSLPQESRIVELGGLTIYPDQNEAEWNSVRILFSQK EFQLLSIFVREHKKIVSRDELLEALWDDVDFVDDNTLTVNVNRLRRKLENAGLTDCIS TIRGQGYQFQVNRKDEAEC*" /label="psdR CDS" gene complement(3218536..3219249) /gene="psdR" /locus_tag="BSU_34720" /old_locus_tag="BSU34720" /label="psdR gene" promotor_-10 complement(3219295..3219314) /Source="Nicolas_upshift_promotors" /id="U2725" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2304 /SigmaFactorBS="acctttatcattctatcataacaaaaagaaaaagaccGATTt actattccgcaCATGCTATAATAATTTTGGAatcttctagaaaaatcatcgtgatgta c" /listShort="yvcP, yvcQ, S1321, yvcR, yvcS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3219307) /Source="Nicolas_upshifts" /id="U2725" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2304 /SigmaFactorBS="acctttatcattctatcataacaaaaagaaaaagaccGATTt actattccgcaCATGCTATAATAATTTTGGAatcttctagaaaaatcatcgtgatgta c" /listShort="yvcP, yvcQ, S1321, yvcR, yvcS" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3219309..3219570) /Source="Nicolas_S_feature" /locus_tag="new_3568195_3568456_c" /HighExp="H2O2, G135, G180, Cold, Paraq, G150, dia15, Oxctl, LBGexp, C30" /AntisenseName="yvzJ" /AntisenseCor="0.56014644713727801" /AntisenseRegPval="-22.9" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.997" /TUlongSig="SigA, SigA" /TUlongPSig="1, 0.999" /label="S1322" promotor_-35 complement(3219327..3219330) /Source="Nicolas_upshift_promotors" /id="U2725" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2304 /SigmaFactorBS="acctttatcattctatcataacaaaaagaaaaagaccGATTt actattccgcaCATGCTATAATAATTTTGGAatcttctagaaaaatcatcgtgatgta c" /listShort="yvcP, yvcQ, S1321, yvcR, yvcS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3219330..3219337 /Source="Nicolas_upshift_promotors" /id="U2726" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.888111888111888" /psig=1 /xcortree=1902 /SigmaFactorBS="attccaaaattattatagcatgtgcggaatagtaaatCGGTC TTTttctttttgtTATGATAGAATGATAAAGGTaaaattttcataataggcaggtgtc g" /listShort="yvzJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3219348..3219367 /Source="Nicolas_upshift_promotors" /id="U2726" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.888111888111888" /psig=1 /xcortree=1902 /SigmaFactorBS="attccaaaattattatagcatgtgcggaatagtaaatCGGTC TTTttctttttgtTATGATAGAATGATAAAGGTaaaattttcataataggcaggtgtc g" /listShort="yvzJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3219353 /Source="Nicolas_upshifts" /id="U2726" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.888111888111888" /psig=1 /xcortree=1902 /SigmaFactorBS="attccaaaattattatagcatgtgcggaatagtaaatCGGTC TTTttctttttgtTATGATAGAATGATAAAGGTaaaattttcataataggcaggtgtc g" /listShort="yvzJ" /GFF_Attribute="listLong" /label="upshifts" CDS 3219396..3219605 /gene="yvzJ" /locus_tag="BSU_34729" /old_locus_tag="BSU34729" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="YP_003097790.1" /db_xref="EnsemblGenomes-Gn:BSU34729" /db_xref="EnsemblGenomes-Tr:CAX52696" /db_xref="GOA:C0H3R7" /db_xref="UniProtKB/Swiss-Prot:C0H3R7" /translation="MKKIMLFLAMTSILSACQPNYTGKYIEIGDTLTDYTKECFKENE IPYKYEKGKLYIPEDAFDTAIYTCS*" /label="yvzJ CDS" gene 3219396..3219605 /gene="yvzJ" /locus_tag="BSU_34729" /old_locus_tag="BSU34729" /label="yvzJ gene" downshifts 3219583 /Source="Nicolas_upshifts" /id="D1798" /incds=0 /nref=7 /ntot=138 /MaxReadThrough="1.16039" /MaxDrop="3.61604" /score="-5.58790836" /energy="-11.4" /TU="NA" /idTUdmin="U2726" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(3219615) /Source="Nicolas_upshifts" /id="D1799" /incds=0 /nref=1 /ntot=3 /MaxReadThrough="3.16808" /MaxDrop="2.84175" /score="16.7711538" /energy="-11.5" /TU="U2727,U2729" /idTUdmin="U2728" /TUdmin=44 /isTUend="FALSE" /label="downshifts" CDS complement(3219641..3220405) /gene="yvcN" /locus_tag="BSU_34730" /old_locus_tag="BSU34730" /EC_number="2.3.1.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10876241; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative arylamine N-acetyltransferase" /protein_id="NP_391353.1" /db_xref="EnsemblGenomes-Gn:BSU34730" /db_xref="EnsemblGenomes-Tr:CAB15478" /db_xref="GOA:O06977" /db_xref="InterPro:IPR001447" /db_xref="SubtiList:BG12404" /db_xref="UniProtKB/Swiss-Prot:O06977" /translation="MIKMSDFLKDCFQKIGWEKDHVSFGDLPLFLKAMAYRFPFENRA VLAKENYKITKEELWRRLLKDQHGGLCYDLNGFLYFVLREAGFHVKLIRGTVYAGDQE GWALEGTHAAVWLSAENGDYLVDIGFGINLALQPIPLSGETVQSPVGSFRIKKEETEK GSYVLLMDKGEGWQIGYAFTLEESDLGDLDNMKDIIHSHEKSPFNKSLLASKLTPSGR MVMSERHFTIYENGGNIQKSDIGPSGFEEKLNTHFL*" /label="yvcN CDS" gene complement(3219641..3220405) /gene="yvcN" /locus_tag="BSU_34730" /old_locus_tag="BSU34730" /label="yvcN gene" downshifts complement(3219663) /Source="Nicolas_upshifts" /id="D1800" /incds=0 /nref=143 /ntot=253 /MaxReadThrough="3.19848" /MaxDrop="6.45069" /score="16.7711538" /energy="-11.5" /TU="U2727,U2729" /idTUdmin="U2728" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS complement(3220406..3220663) /gene="crh" /locus_tag="BSU_34740" /old_locus_tag="BSU34740" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10559153, 10589728, 1136107, 12972249, 15126459, 16411239, 17142398, 21992469, 22092971" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10559153, 10589728, 1136107, 12972249, 15126459, 16411239, 17142398, 21992469, 22092971; Product type r: regulator" /codon_start=1 /transl_table=11 /product="catabolite repression HPr-like protein" /protein_id="NP_391354.1" /db_xref="EnsemblGenomes-Gn:BSU34740" /db_xref="EnsemblGenomes-Tr:CAB15479" /db_xref="InterPro:IPR000032" /db_xref="InterPro:IPR002114" /db_xref="InterPro:IPR035895" /db_xref="PDB:1K1C" /db_xref="PDB:1MO1" /db_xref="PDB:1MU4" /db_xref="PDB:1ZVV" /db_xref="PDB:2AK7" /db_xref="PDB:2RLZ" /db_xref="SubtiList:BG12403" /db_xref="UniProtKB/Swiss-Prot:O06976" /translation="MVQQKVEVRLKTGLQARPAALFVQEANRFTSDVFLEKDGKKVNA KSIMGLMSLAVSTGTEVTLIAQGEDEQEALEKLAAYVQEEV*" /label="crh CDS" gene complement(3220406..3220663) /gene="crh" /locus_tag="BSU_34740" /old_locus_tag="BSU34740" /label="crh gene" CDS complement(3220687..3221637) /gene="whiA" /locus_tag="BSU_34750" /old_locus_tag="BSU34750" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10986251, 17603302, 19836336, 24097947; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative morphogen" /protein_id="NP_391355.1" /db_xref="EnsemblGenomes-Gn:BSU34750" /db_xref="EnsemblGenomes-Tr:CAB15480" /db_xref="GOA:O06975" /db_xref="InterPro:IPR003802" /db_xref="InterPro:IPR018478" /db_xref="InterPro:IPR023054" /db_xref="InterPro:IPR027434" /db_xref="InterPro:IPR033981" /db_xref="SubtiList:BG12402" /db_xref="UniProtKB/Swiss-Prot:O06975" /translation="MSFASETKKELTNLEVKDCCINAELSALIRMNGALSFTNRHLVL DVQTENAAIARRIYTLLKKQYDVSVELLVRKKMRLKKNNVYIVRFSENAKAILEDLKI LGENFVFERSISKELVKKRCCKRSYMRGAFLAGGSVNNPETSSYHLEIFSLYKEHNDS LCDLLNEFQLNSKTLERKKGYITYLKEAEKITEFLNVIGAHNSLLRFEDVRIVRDMRN SVNRLVNCETANLNKTIGASLRQVENIKYIDERIGLEALPEKLREIAQLRIDYQEVTL KELGEMVASGKISKSGINHRLRKLDEIAEQLRTGQTVTLK*" /label="whiA CDS" gene complement(3220687..3221637) /gene="whiA" /locus_tag="BSU_34750" /old_locus_tag="BSU34750" /label="whiA gene" CDS complement(3221660..3222613) /gene="mgfK" /locus_tag="BSU_34760" /old_locus_tag="BSU34760" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11888293, 16272399, 21320184, 21371139, 25012659, 27806131, 28646159" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11888293, 16272399, 21320184, 21371139, 25012659, 27806131, 28646159; Product type f: factor" /codon_start=1 /transl_table=11 /product="gluconeogenesis morphogenetic factor (UDP-sugar binding)" /protein_id="NP_391356.2" /db_xref="EnsemblGenomes-Gn:BSU34760" /db_xref="EnsemblGenomes-Tr:CAB15481" /db_xref="GOA:O06974" /db_xref="InterPro:IPR002882" /db_xref="InterPro:IPR010119" /db_xref="SubtiList:BG12401" /db_xref="UniProtKB/Swiss-Prot:O06974" /translation="MGQKPKIAIFGGGTGLSVLLRGLKHKPVDITAIVTVADDGGSSG RLRNELKIPPPGDIRNVLAALSDVEPLVEDLFQHRFNKGNDLTGHSLGNLILAAMTNI TGDFFHAVTEMSKVLNVRGKVLPAANASVVLHAEMEDGRVVSGESTIPEYGQRIKRVF LTPEQIDPLPETIDVIREADLIIIGPGSLYTSILPNLLVPKIGEEVIKAPAKKVYICN VMTQPGETLHYTAADHVKALNQHMGCGFIDTILVNSEDIPDEIKRKYEMESARPVDFD IEELKAMGLEVIRDQIVTYKNDVIRHDTHKVASLLVDLLKE*" /label="mgfK CDS" gene complement(3221660..3222613) /gene="mgfK" /locus_tag="BSU_34760" /old_locus_tag="BSU34760" /label="mgfK gene" CDS complement(3222615..3223502) /gene="yvcJ" /locus_tag="BSU_34770" /old_locus_tag="BSU34770" /function="15.6: DNA transformation" /experiment="publication(s) with functional evidences, PMID:18334534, 19074378, 21179021, 21709426" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18334534, 19074378, 21179021, 21709426; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="GTPase possibly involved in regulator sRNA degradation" /protein_id="NP_391357.1" /db_xref="EnsemblGenomes-Gn:BSU34770" /db_xref="EnsemblGenomes-Tr:CAB15482" /db_xref="GOA:O06973" /db_xref="InterPro:IPR005337" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12400" /db_xref="UniProtKB/Swiss-Prot:O06973" /translation="MSVSESHDIQLVIITGMSGAGKTVAIQSFEDLGYFCVDNLPPSL LPKFLELMKESNSKMSKVALVMDLRGREFFDRLIEALDEMAENPWITPRILFLDAKDS ILVTRYKETRRSHPLAATGLPLEGIALERELLEELKGRSQIIYDTSDMKPRDLREKIV KHFATNQGETFTVNVMSFGFKYGIPIDADLVFDVRFLPNPYYIESMRPLTGKDKEVSS YVMKWNETQKFNEKLIDLLSFMLPSYKREGKSQVVIAIGCTGGQHRSVTLAENLADYF KKDYYTHVTHRDIEKRSRK*" /label="yvcJ CDS" gene complement(3222615..3223502) /gene="yvcJ" /locus_tag="BSU_34770" /old_locus_tag="BSU34770" /label="yvcJ gene" CDS complement(3223527..3224003) /gene="yvcI" /locus_tag="BSU_34780" /old_locus_tag="BSU34780" /EC_number="3.6.-.-" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative triphosphate pyrophosphate hydrolase" /protein_id="NP_391358.1" /db_xref="EnsemblGenomes-Gn:BSU34780" /db_xref="EnsemblGenomes-Tr:CAB15483" /db_xref="GOA:O06972" /db_xref="InterPro:IPR000086" /db_xref="InterPro:IPR015797" /db_xref="InterPro:IPR020476" /db_xref="SubtiList:BG12399" /db_xref="UniProtKB/Swiss-Prot:O06972" /translation="MTYLQRVTNCVLQTDDKVLLLQKPRRGWWVAPGGKMESGESVRD SVIREYREETGIYIINPQLKGVFTFIIKDGDHIVSEWMMFTFVADSYTGQNVSESEEG KLQWHDVNDIQNLPMAPGDGHILDFMMKGQGLLHGTFTYTPEFELLSYRLDPQHIK*" /label="yvcI CDS" gene complement(3223527..3224003) /gene="yvcI" /locus_tag="BSU_34780" /old_locus_tag="BSU34780" /label="yvcI gene" promotor_-10 complement(3224023..3224042) /Source="Nicolas_upshift_promotors" /id="U2727" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.588411588411588" /psig=1 /xcortree=2664 /SigmaFactorBS="ctgtaaaatagaagaaaagattgtcaatgtctcttCATTGtg ggaggcatcttgaAGCGGTATAATAAAGAGACGatgacaggacgaaggttaggtgacg t" /listShort="yvcI, yvcJ, yvcK, whiA, crh, yvcN, S1322, yvcP, yvcQ, S1321, yvcR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3224037) /Source="Nicolas_upshifts" /id="U2727" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.588411588411588" /psig=1 /xcortree=2664 /SigmaFactorBS="ctgtaaaatagaagaaaagattgtcaatgtctcttCATTGtg ggaggcatcttgaAGCGGTATAATAAAGAGACGatgacaggacgaaggttaggtgacg t" /listShort="yvcI, yvcJ, yvcK, whiA, crh, yvcN, S1322, yvcP, yvcQ, S1321, yvcR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3224058..3224062) /Source="Nicolas_upshift_promotors" /id="U2727" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.588411588411588" /psig=1 /xcortree=2664 /SigmaFactorBS="ctgtaaaatagaagaaaagattgtcaatgtctcttCATTGtg ggaggcatcttgaAGCGGTATAATAAAGAGACGatgacaggacgaaggttaggtgacg t" /listShort="yvcI, yvcJ, yvcK, whiA, crh, yvcN, S1322, yvcP, yvcQ, S1321, yvcR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3224081..3224100) /Source="Nicolas_upshift_promotors" /id="U2728" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.572427572427572" /psig="0.982017982017982" /xcortree=1583 /SigmaFactorBS="ataaataaaagagaattccagttacagcaaaatcatCTGAat taaggaatgaatATGCTGTAAAATAGAAGAAAagattgtcaatgtctcttcattgtgg g" /listShort="yvcI, yvcJ, yvcK, whiA, crh, yvcN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3224094) /Source="Nicolas_upshifts" /id="U2728" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.572427572427572" /psig="0.982017982017982" /xcortree=1583 /SigmaFactorBS="ataaataaaagagaattccagttacagcaaaatcatCTGAat taaggaatgaatATGCTGTAAAATAGAAGAAAagattgtcaatgtctcttcattgtgg g" /listShort="yvcI, yvcJ, yvcK, whiA, crh, yvcN" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3224115..3224118) /Source="Nicolas_upshift_promotors" /id="U2728" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.572427572427572" /psig="0.982017982017982" /xcortree=1583 /SigmaFactorBS="ataaataaaagagaattccagttacagcaaaatcatCTGAat taaggaatgaatATGCTGTAAAATAGAAGAAAagattgtcaatgtctcttcattgtgg g" /listShort="yvcI, yvcJ, yvcK, whiA, crh, yvcN" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3224170..3224320) /Source="Nicolas_S_feature" /locus_tag="new_3573056_3573206_c" /HighExp="dia15, Diami, dia5, H2O2, Etha, LPhT, Cold, Paraq, C30, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 1" /TUlongSig="SigA" /TUlongPSig="0.999" /label="S1323" downshifts complement(3224213) /Source="Nicolas_upshifts" /id="D1801" /incds=0 /nref=9 /ntot=78 /MaxReadThrough="6.94979" /MaxDrop="3.73811" /score="11.9453839" /energy="-11" /TU="U2729,U2733" /idTUdmin="U2734" /TUdmin=2904 /isTUend="FALSE" /label="downshifts" CDS complement(3224321..3225271) /gene="trxB" /locus_tag="BSU_34790" /old_locus_tag="BSU34790" /EC_number="1.8.1.9" /function="16.6: Maintain" /function="16.10: Respire" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14597697, 15659166, 23813734, 24401092" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14597697, 15659166, 23813734, 24401092; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thioredoxin reductase" /protein_id="NP_391359.1" /db_xref="EnsemblGenomes-Gn:BSU34790" /db_xref="EnsemblGenomes-Tr:CAB15484" /db_xref="GOA:P80880" /db_xref="InterPro:IPR000103" /db_xref="InterPro:IPR005982" /db_xref="InterPro:IPR008255" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG12398" /db_xref="UniProtKB/Swiss-Prot:P80880" /translation="MSEEKIYDVIIIGAGPAGMTAAVYTSRANLSTLMIERGIPGGQM ANTEDVENYPGFESILGPELSNKMFEHAKKFGAEYAYGDIKEVIDGKEYKVVKAGSKE YKARAVIIAAGAEYKKIGVPGEKELGGRGVSYCAVCDGAFFKGKELVVVGGGDSAVEE GVYLTRFASKVTIVHRRDKLRAQSILQARAFDNEKVDFLWNKTVKEIHEENGKVGNVT LVDTVTGEESEFKTDGVFIYIGMLPLSKPFENLGITNEEGYIETNDRMETKVEGIFAA GDIREKSLRQIVTATGDGSIAAQSVQHYVEELQETLKTLK*" /label="trxB CDS" gene complement(3224321..3225271) /gene="trxB" /locus_tag="BSU_34790" /old_locus_tag="BSU34790" /label="trxB gene" S_feature complement(3225272..3225359) /Source="Nicolas_S_feature" /locus_tag="new_3574158_3574245_c" /HighExp="dia5, Diami, dia15, H2O2, Etha, Salt, Cold, Paraq, LPhT, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.997, 1" /TUlongSig="SigA" /TUlongPSig="0.999" /label="S1324" promotor_-10 complement(3225348..3225367) /Source="Nicolas_upshift_promotors" /id="U2729" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.507492507492508" /psig="0.997002997002997" /xcortree=2036 /SigmaFactorBS="ttttcgaatacatttaatcgtgttgagcaaaaaaATAGcgta tcaccatgagATTTTATAGGATATGGGTAAggaatacgtttgatggggattcttatct t" /listShort="S1324, trxB, S1323, yvcI, yvcJ, yvcK, whiA, crh, yvcN, S1322, yvcP, yvcQ, S1321, yvcR, yvcS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3225359) /Source="Nicolas_upshifts" /id="U2729" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.507492507492508" /psig="0.997002997002997" /xcortree=2036 /SigmaFactorBS="ttttcgaatacatttaatcgtgttgagcaaaaaaATAGcgta tcaccatgagATTTTATAGGATATGGGTAAggaatacgtttgatggggattcttatct t" /listShort="S1324, trxB, S1323, yvcI, yvcJ, yvcK, whiA, crh, yvcN, S1322, yvcP, yvcQ, S1321, yvcR, yvcS" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3225361..3225452) /Source="Nicolas_S_feature" /locus_tag="new_3574247_3574338_c" /HighExp="Cold, Oxctl, G180, G135, Paraq, C30, LBGexp, G150, S1, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.999" /label="S1325" promotor_-35 complement(3225382..3225385) /Source="Nicolas_upshift_promotors" /id="U2729" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.507492507492508" /psig="0.997002997002997" /xcortree=2036 /SigmaFactorBS="ttttcgaatacatttaatcgtgttgagcaaaaaaATAGcgta tcaccatgagATTTTATAGGATATGGGTAAggaatacgtttgatggggattcttatct t" /listShort="S1324, trxB, S1323, yvcI, yvcJ, yvcK, whiA, crh, yvcN, S1322, yvcP, yvcQ, S1321, yvcR, yvcS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3225400..3225406 /Source="Nicolas_upshift_promotors" /id="U2730" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=199 /SigmaFactorBS="gtgatacgctatttttttgctcaacaCGATTAAatgtattcg aaaaGGGTATATGTTAATAAAGAaagagccttctgtttatagaaggcccttgtcatat t" /listShort="S1326" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3225420..3225438 /Source="Nicolas_upshift_promotors" /id="U2730" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=199 /SigmaFactorBS="gtgatacgctatttttttgctcaacaCGATTAAatgtattcg aaaaGGGTATATGTTAATAAAGAaagagccttctgtttatagaaggcccttgtcatat t" /listShort="S1326" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3225434 /Source="Nicolas_upshifts" /id="U2730" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=199 /SigmaFactorBS="gtgatacgctatttttttgctcaacaCGATTAAatgtattcg aaaaGGGTATATGTTAATAAAGAaagagccttctgtttatagaaggcccttgtcatat t" /listShort="S1326" /GFF_Attribute="listLong" /label="upshifts" S_feature 3225435..3228821 /Source="Nicolas_S_feature" /locus_tag="new_3574321_3577707" /HighExp="Sw, M9-stat, B60, T0.30H, Gly, BC, B36, T1.0H, Salt, C30" /AntisenseName="yvcD" /AntisenseCor="-0.261780844003138" /AntisenseRegPval="-4.9000000000000004" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1326" CDS complement(3225477..3226898) /gene="cwlO" /locus_tag="BSU_34800" /old_locus_tag="BSU34800" /EC_number="3.4.-.-" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:15187182, 16233686, 21478646, 22139507, 23855774, 24163346, 24769902" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15187182, 16233686, 21478646, 22139507, 23855774, 24163346, 24769902; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="secreted cell wall DL-endopeptidase" /protein_id="NP_391360.1" /db_xref="EnsemblGenomes-Gn:BSU34800" /db_xref="EnsemblGenomes-Tr:CAB15485" /db_xref="GOA:P40767" /db_xref="InterPro:IPR000064" /db_xref="SubtiList:BG11023" /db_xref="UniProtKB/Swiss-Prot:P40767" /translation="MRKSLITLGLASVIGTSSFLIPFTSKTASAETLDEKKQKIESKQ SEVASSIEAKEKELTELQENQSKIEKELKDINDKALDTSNKIEDKKEENDKTKEEIKK LKKEIKETEARIEKRNEILKKRVRSLQESGGSQGYIDVLLGSTSFGDFISRATAVSSI VDADKDLIKQQEQDKAKLEDSEADLNDKLKEVQAALAKLETMQKDLDKQLNEKDKLFD EAKASQKKTAKAISELKSEASELANQKANTEAEQARIKKEQEAAAALIKKQEEAQKAS DETQTDDSQTATTESSKASSSDDSSDNSSDNSSNGSSNSSSNGSSSKKSSGSNSNSGG TVISNSGGIEGAISVGSSIVGQSPYKFGGGRTQSDINNRIFDCSSFVRWAYASAGVNL GPVGGTTTDTLVGRGQAVSASEMKRGDLVFFDTYKTNGHVGIYLGNGTFLNDNTSHGV SVDSMSNPYWKAAFKGVVRRVVQ*" /label="cwlO CDS" gene complement(3225477..3226898) /gene="cwlO" /locus_tag="BSU_34800" /old_locus_tag="BSU34800" /label="cwlO gene" downshifts complement(3225497) /Source="Nicolas_upshifts" /id="D1802" /incds=0 /nref=8 /ntot=106 /MaxReadThrough="6.31311" /MaxDrop="3.4602" /score="1.76249731" /energy="-12.1" /TU="U2733" /idTUdmin="U2734" /TUdmin=1620 /isTUend="FALSE" /label="downshifts" downshifts complement(3225621) /Source="Nicolas_upshifts" /id="D1803" /incds=1 /nref=1 /ntot=20 /MaxReadThrough="7.07718" /MaxDrop="2.13349" /score="1.76249731" /energy="-12.1" /TU="U2733" /idTUdmin="U2734" /TUdmin=1496 /isTUend="FALSE" /label="downshifts" misc_feature 3226525..3226529 /Source="Nicolas_upshift_promotors" /id="U2731" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.963036963036963" /psig="0.002997002997003" /xcortree=52 /SigmaFactorBS="aaagaacatctatgtatccttgagatccgccgctttcctgta aagaacgaACGCGttttttcaggatttcattgcgtttttcgatgcgtgcttcagtttc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3226535 /Source="Nicolas_upshifts" /id="U2731" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.963036963036963" /psig="0.002997002997003" /xcortree=52 /SigmaFactorBS="aaagaacatctatgtatccttgagatccgccgctttcctgta aagaacgaACGCGttttttcaggatttcattgcgtttttcgatgcgtgcttcagtttc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 3226814..3226818 /Source="Nicolas_upshift_promotors" /id="U2732" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.84015984015984" /psig="0.130869130869131" /xcortree=42 /SigmaFactorBS="ctcagattgcttgctttcgattttttgtttcttttcatctaa tgtttccgccgATGCAgttttacttgtaaatgggatcaaaaaactgcttgtcccgatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3226821 /Source="Nicolas_upshifts" /id="U2732" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.84015984015984" /psig="0.130869130869131" /xcortree=42 /SigmaFactorBS="ctcagattgcttgctttcgattttttgtttcttttcatctaa tgtttccgccgATGCAgttttacttgtaaatgggatcaaaaaactgcttgtcccgatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3226899..3227096) /Source="Nicolas_S_feature" /locus_tag="new_3575785_3575982_c" /HighExp="S1, Cold, T-3.40H, M9-exp, MG t5, MG 5, MG 15, T-5.40H, GM-0.2, MG-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.999" /label="S1327" downshifts 3227019 /Source="Nicolas_upshifts" /id="D1804" /incds=0 /nref=2 /ntot=119 /MaxReadThrough="6.41604" /MaxDrop="3.8522" /score="6.14322693" /energy="-7.6" /TU="U2730,U2731" /idTUdmin="U2731" /TUdmin="-1408" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3227084..3227103) /Source="Nicolas_upshift_promotors" /id="U2733" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.431568431568432" /psig=1 /xcortree=2537 /SigmaFactorBS="catctgtttgaaacataaatgtaataaaatttatCGCTAATT tgtcgaaacttGATGGTATAATGATTCTCGTacataaggaattagtgttttttacata t" /listShort="S1327, cwlO, S1325, S1324, trxB, S1323, yvcI, yvcJ, yvcK, whiA, crh, yvcN" /listLong="S1322, yvcP, yvcQ, S1321, yvcR, yvcS" /label="promotor_-10" upshifts complement(3227096) /Source="Nicolas_upshifts" /id="U2733" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.431568431568432" /psig=1 /xcortree=2537 /SigmaFactorBS="catctgtttgaaacataaatgtaataaaatttatCGCTAATT tgtcgaaacttGATGGTATAATGATTCTCGTacataaggaattagtgttttttacata t" /listShort="S1327, cwlO, S1325, S1324, trxB, S1323, yvcI, yvcJ, yvcK, whiA, crh, yvcN" /listLong="S1322, yvcP, yvcQ, S1321, yvcR, yvcS" /label="upshifts" promotor_-35 complement(3227115..3227122) /Source="Nicolas_upshift_promotors" /id="U2733" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.431568431568432" /psig=1 /xcortree=2537 /SigmaFactorBS="catctgtttgaaacataaatgtaataaaatttatCGCTAATT tgtcgaaacttGATGGTATAATGATTCTCGTacataaggaattagtgttttttacata t" /listShort="S1327, cwlO, S1325, S1324, trxB, S1323, yvcI, yvcJ, yvcK, whiA, crh, yvcN" /listLong="S1322, yvcP, yvcQ, S1321, yvcR, yvcS" /label="promotor_-35" CDS complement(3227279..3228733) /gene="yvcD" /locus_tag="BSU_34810" /old_locus_tag="BSU34810" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391361.1" /db_xref="EnsemblGenomes-Gn:BSU34810" /db_xref="EnsemblGenomes-Tr:CAB15486" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="SubtiList:BG12396" /db_xref="UniProtKB/Swiss-Prot:O06968" /translation="MGKHTSEHKNHAQIVQLLQDGQYFFHKGLKAYKERNLKRASKLI QRAVHLEPEDSEMLSQLAVIYSEMGQYQESNDLLDYIMANLEAEMPECHYFKANNFAH LGLFQEAYKEAAAYSDADPDGEFAEENDSLLDLLDLGDDGIEDSLYDQDELLVKQDRA KSLLESGQLAEAVAALEEITTEYPELWSAYNNLALAYFYSGNVVKAKQTAYEVLSHNE GNLHALCNLLVFYYYEREDEKVAELSDQLSNVYPMLLEQRYKLGATLALVGRYEIGYK WLKSLYKTGFEGDDTFFYWLSCSAYFTGHTDFAETIWRKVESQYPGEDRPAPWIERRE ALPSSVEQRLAAYYISSTKGETEHLEAVIRSKRITAPFETHFVKLLLNGDSAAADVSE DALFAYQTVKLLEQAEKEEMKTEVMSCWVFHVIQQIRAAAPLKNEKGWAAAICYIWKE AHGKQDTKKDTAARFGISPATLTKYMKYIDDILE*" /label="yvcD CDS" gene complement(3227279..3228733) /gene="yvcD" /locus_tag="BSU_34810" /old_locus_tag="BSU34810" /label="yvcD gene" downshifts complement(3227299) /Source="Nicolas_upshifts" /id="D1805" /incds=0 /nref=11 /ntot=190 /MaxReadThrough="3.36188" /MaxDrop="3.98985" /score="16.3455178" /energy="-9.1" /TU="U2734" /idTUdmin="U2734" /TUdmin="-182" /isTUend="FALSE" /label="downshifts" S_feature complement(3228734..3228858) /Source="Nicolas_S_feature" /locus_tag="new_3577620_3577744_c" /HighExp="LBGstat, Sw, Cold, BC, BI, Lbexp, dia0, G150, LBGtran, M40t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1328" downshifts 3228779 /Source="Nicolas_upshifts" /id="D1806" /incds=0 /nref=4 /ntot=36 /MaxReadThrough="1.81602" /MaxDrop="3.41181" /score="7.59889121" /energy="-9.9" /TU="NA" /idTUdmin="U2730" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3228859..3230628) /gene="bmrA" /locus_tag="BSU_34820" /old_locus_tag="BSU34820" /EC_number="3.6.3.-" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16405427, 18215075, 21077936, 22711831, 24630999" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16405427, 18215075, 21077936, 22711831, 24630999; Product type t : transporter" /codon_start=1 /transl_table=11 /product="efflux transporter (ATP-binding and permease protein)" /protein_id="NP_391362.1" /db_xref="EnsemblGenomes-Gn:BSU34820" /db_xref="EnsemblGenomes-Tr:CAB15487" /db_xref="GOA:O06967" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG12395" /db_xref="UniProtKB/Swiss-Prot:O06967" /translation="MPTKKQKSKSKLKPFFALVRRTNPSYGKLAFALALSVVTTLVSL LIPLLTKQLVDGFSMSNLSGTQIGLIALVFFVQAGLSAYATYALNYNGQKIISGLREL LWKKLIKLPVSYFDTNASGETVSRVTNDTMVVKELITTHISGFITGIISVIGSLTILF IMNWKLTLLVLVVVPLAALILVPIGRKMFSISRETQDETARFTGLLNQILPEIRLVKA SNAEDVEYGRGKMGISSLFKLGVREAKVQSLVGPLISLVLMAALVAVIGYGGMQVSSG ELTAGALVAFILYLFQIIMPMGQITTFFTQLQKSIGATERMIEILAEEEEDTVTGKQI ENAHLPIQLDRVSFGYKPDQLILKEVSAVIEAGKVTAIVGPSGGGKTTLFKLLERFYS PTAGTIRLGDEPVDTYSLESWREHIGYVSQESPLMSGTIRENICYGLERDVTDAEIEK AAEMAYALNFIKELPNQFDTEVGERGIMLSGGQRQRIAIARALLRNPSILMLDEATSS LDSQSEKSVQQALEVLMEGRTTIVIAHRLSTVVDADQLLFVEKGEITGRGTHHELMAS HGLYRDFAEQQLKMNADLENKAG*" /label="bmrA CDS" gene complement(3228859..3230628) /gene="bmrA" /locus_tag="BSU_34820" /old_locus_tag="BSU34820" /label="bmrA gene" S_feature complement(3230629..3230703) /Source="Nicolas_S_feature" /locus_tag="new_3579515_3579589_c" /HighExp="LBGstat, Cold, Lbexp, G150, Oxctl, dia0, T1.30H, T0.30H, BC, T1.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1329" misc_feature complement(3230692..3230711) /Source="Nicolas_upshift_promotors" /id="U2734" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.756243756243756" /psig="0.999000999001" /xcortree=2142 /SigmaFactorBS="gggagatttttattttgatcacggcaaaaatatactgaaaaa gtctttctccATTGATATGATTGAGAAAGAgtaaaaatcatccttttgctatgacttt t" /listShort="S1329, bmrA, S1328, yvcD" /listLong="S1327, cwlO, S1325, S1324, trxB, S1323, yvcI, yvcJ, yvcK, whiA, crh, yvcN, S1322, yvcP, yvcQ, S1321, yvcR, yvcS" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3230703) /Source="Nicolas_upshifts" /id="U2734" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.756243756243756" /psig="0.999000999001" /xcortree=2142 /SigmaFactorBS="gggagatttttattttgatcacggcaaaaatatactgaaaaa gtctttctccATTGATATGATTGAGAAAGAgtaaaaatcatccttttgctatgacttt t" /listShort="S1329, bmrA, S1328, yvcD" /listLong="S1327, cwlO, S1325, S1324, trxB, S1323, yvcI, yvcJ, yvcK, whiA, crh, yvcN, S1322, yvcP, yvcQ, S1321, yvcR, yvcS" /label="upshifts" CDS complement(3230793..3231152) /gene="yvzA" /locus_tag="BSU_34830" /old_locus_tag="BSU34830" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391363.1" /db_xref="EnsemblGenomes-Gn:BSU34830" /db_xref="EnsemblGenomes-Tr:CAB15488" /db_xref="SubtiList:BG14157" /db_xref="UniProtKB/Swiss-Prot:O32265" /translation="MTSLFSESETEIVSTTYMFLTQDEMKGKAGTLNQPINDFLSLTK KFESSLKEEIKGQKGLIVKKIKKELESNSEKRKAALQMIKEEHTAKVDRYKMIIEDLR QQDVTLTYRKKKPVKDV*" /label="yvzA CDS" gene complement(3230793..3231152) /gene="yvzA" /locus_tag="BSU_34830" /old_locus_tag="BSU34830" /label="yvzA gene" downshifts complement(3230813) /Source="Nicolas_upshifts" /id="D1807" /incds=0 /nref=146 /ntot=246 /MaxReadThrough="2.52417" /MaxDrop="4.81771" /score="18.5636016" /energy="-13.2" /TU="NA" /idTUdmin="U2735" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3231167..3233077) /gene="yvcB" /locus_tag="BSU_34840" /old_locus_tag="BSU34840" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391364.1" /db_xref="EnsemblGenomes-Gn:BSU34840" /db_xref="EnsemblGenomes-Tr:CAB15489" /db_xref="SubtiList:BG12394" /db_xref="UniProtKB/Swiss-Prot:O06966" /translation="MGNKNVFENENVKLRLIDLEYDYKQKFASTIASEVKKAKKDFEA DIRRIYKEETHHDLPENMKIEIYTSNELVNQNTSIQSSTRESGYDGTAIHIIDEKKHI DQLQIISEGSADNKDWSYNFFGLFLGIDHSQYEATKEFTNKAKKAAGNSEDLKTFALG HSLANNNQVMVQLIDGEYDEVYGVNGAQVNIDQLLETDESLYRYVIRKFSYKYEDIDS IPPEKLKKEIQKYYEDKGVTTNITQRISKDDPLYGVSGKADFITFGDVKMADTNTSVK GIRNIMDGVPDEDVRSIQKFLQKYKDDYEKDGLNGFIKAASGIDIDLIEKVKNTDGAL KKVSVLYEHFDDVKQMYGRIKEELPSFLGFLHTLLRNSGPVVDQLAENGYIDETQKKV IKKELTNINASMRGIESRYEHFIDHLKHGQFMQALKDVGEIVDYVKSILSSLKTLDTE TKDALKLIVDGHSIVQMLNALSKEKGFSYKGSDIYFTGKSGSGETIQVNLSSAVRIYQ NGMKIVEDMEDAISKYQKVYSQEIDEDFIDKKQAIITAIHHMEENPSHYAFDLQFRLA AGFSHTFDKLEKISVHESFHTGALPANDGIVAELKKQTTEKRDFIKNIRESIEKLFEK EEMISQLFDFQS*" /label="yvcB CDS" gene complement(3231167..3233077) /gene="yvcB" /locus_tag="BSU_34840" /old_locus_tag="BSU34840" /label="yvcB gene" CDS complement(3233079..3233804) /gene="yvcA" /locus_tag="BSU_34850" /old_locus_tag="BSU34850" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17590234; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_391365.1" /db_xref="EnsemblGenomes-Gn:BSU34850" /db_xref="EnsemblGenomes-Tr:CAB15490" /db_xref="GOA:O06965" /db_xref="SubtiList:BG12393" /db_xref="UniProtKB/Swiss-Prot:O06965" /translation="MKKIIFICFSLLLALTGGCSMNDNDKNSTNDNKTEAVKPKDMDP KDLPQVPAFQDEKTREYMVSTKEEEPGYYLLESKLKGFRMLFPEDGKYLSRRSSLTGK NKESIGFNSYDKDTNVMFDGHVTYYKEESFANEPKTMLDIVSGKNDYKGEYKKSSKKK TDIYTAKKKDIFDDIDRKYNYSYSYFGYVKSTEEDNLGVEYAFTLGCKNENQPCSLDE EKAKNKVEKLINSITFLIDKKEK*" /label="yvcA CDS" gene complement(3233079..3233804) /gene="yvcA" /locus_tag="BSU_34850" /old_locus_tag="BSU34850" /label="yvcA gene" S_feature complement(3233805..3233893) /Source="Nicolas_S_feature" /locus_tag="new_3582691_3582779_c" /HighExp="T1.30H, T0.30H, T1.0H, T2.0H, T2.30H, T3.0H, T-1.40H, T-1.10H, MG 150, HiOs" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.982, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1330" promotor_-10 complement(3233893..3233912) /Source="Nicolas_upshift_promotors" /id="U2735" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.446553446553447" /psig="0.982017982017982" /xcortree=2982 /SigmaFactorBS="tcaaaaccgagtctcatttcctATTTatccaaattccgccaT GATGTAACATGAAAAAGGAtgaaataatcatctcttaaccaggtcaatagaattattt t" /listShort="S1330, yvcA, yvcB, yvzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3233893) /Source="Nicolas_upshifts" /id="U2735" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.446553446553447" /psig="0.982017982017982" /xcortree=2982 /SigmaFactorBS="tcaaaaccgagtctcatttcctATTTatccaaattccgccaT GATGTAACATGAAAAAGGAtgaaataatcatctcttaaccaggtcaatagaattattt t" /listShort="S1330, yvcA, yvcB, yvzA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3233895..3234024) /Source="Nicolas_S_feature" /locus_tag="new_3582781_3582910_c" /HighExp="Etha, Diami, HiTm, T1.0H, Cold, MG 15, T0.30H, BMM, T1.30H, MG 10" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1331" promotor_-35 complement(3233928..3233931) /Source="Nicolas_upshift_promotors" /id="U2735" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.446553446553447" /psig="0.982017982017982" /xcortree=2982 /SigmaFactorBS="tcaaaaccgagtctcatttcctATTTatccaaattccgccaT GATGTAACATGAAAAAGGAtgaaataatcatctcttaaccaggtcaatagaattattt t" /listShort="S1330, yvcA, yvcB, yvzA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3234050..3234679) /gene="hisIE" /locus_tag="BSU_34860" /old_locus_tag="BSU34860" /EC_number="3.5.4.19" /EC_number="3.6.1.31" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15871048, 17767732; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="bifunctional phosphoribosyl-AMP cyclohydrolase; phosphoribosyl-ATP pyrophosphohydrolase" /protein_id="NP_391366.1" /db_xref="EnsemblGenomes-Gn:BSU34860" /db_xref="EnsemblGenomes-Tr:CAB15491" /db_xref="GOA:O34912" /db_xref="InterPro:IPR002496" /db_xref="InterPro:IPR008179" /db_xref="InterPro:IPR021130" /db_xref="InterPro:IPR023019" /db_xref="InterPro:IPR026660" /db_xref="SubtiList:BG12603" /db_xref="UniProtKB/Swiss-Prot:O34912" /translation="MKQADELRFNEDGLIPAIVQDAASKEVLTLAYMNKESYEKTLET KETWFYSRSRQALWHKGETSGNTQAVKGIRYDCDQDALLVLVEPSGPACHTGSYSCFT KEQTEEQAADRFGIMNELERVIAERQAEMPEGAYTTYLFREGVDKILKKVGEEASEVI IAAKNRDHEELKWEAADLLYHLLVLLREQSLPLDDVLDVLKKRHSEIEE*" /label="hisIE CDS" gene complement(3234050..3234679) /gene="hisIE" /locus_tag="BSU_34860" /old_locus_tag="BSU34860" /label="hisIE gene" downshifts complement(3234069) /Source="Nicolas_upshifts" /id="D1808" /incds=0 /nref=104 /ntot=178 /MaxReadThrough="4.37156" /MaxDrop="4.76747" /score="14.9565762" /energy="-8.4" /TU="U2738" /idTUdmin="U2735" /TUdmin="-3256" /isTUend="FALSE" /label="downshifts" CDS complement(3234676..3235434) /gene="hisF" /locus_tag="BSU_34870" /old_locus_tag="BSU34870" /EC_number="4.3.1.-" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1400209, 17767732, 19636909; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="imidazole glycerol phosphate synthase subunit" /protein_id="NP_391367.1" /db_xref="EnsemblGenomes-Gn:BSU34870" /db_xref="EnsemblGenomes-Tr:CAB15492" /db_xref="GOA:O34727" /db_xref="InterPro:IPR004651" /db_xref="InterPro:IPR006062" /db_xref="InterPro:IPR011060" /db_xref="InterPro:IPR013785" /db_xref="SubtiList:BG12600" /db_xref="UniProtKB/Swiss-Prot:O34727" /translation="MITKRIIPCLDVKEGRVVKGIQFLELKDAGDPVELAEVYDREGA DELVFLDISASHEGRKTMVDVVEQVAAKLAIPFTVGGGINQLSDMKTILRAGADKVSV NTAAVLRPELITEGAEFFGSQCIVLAIDAKYDKESDTYKVYTHGGRKKTDWEVTAWAK EGVKRGAGEILLTSMDSDGEKKGFDHTLTKLVSEAVPVPVIASGGAGNAQHMLEAFTK GEADAALAASIFHYKETSIKEVKSYLKEYGVNVR*" /label="hisF CDS" gene complement(3234676..3235434) /gene="hisF" /locus_tag="BSU_34870" /old_locus_tag="BSU34870" /label="hisF gene" CDS complement(3235431..3236168) /gene="hisA" /locus_tag="BSU_34880" /old_locus_tag="BSU34880" /EC_number="5.3.1.16" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1400209, 26294764; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase" /protein_id="NP_391368.1" /db_xref="EnsemblGenomes-Gn:BSU34880" /db_xref="EnsemblGenomes-Tr:CAB15493" /db_xref="GOA:O35006" /db_xref="InterPro:IPR006062" /db_xref="InterPro:IPR006063" /db_xref="InterPro:IPR011060" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR023016" /db_xref="SubtiList:BG12597" /db_xref="UniProtKB/Swiss-Prot:O35006" /translation="MSAFTLYPAIDMRNGKCVRLVQGDYNKETIYGDSPYDMAELFEK EGAEWIHLVDLDGAKEGKRVNDRHVIEIAQKLNLKVEIGGGIRSENDVYEYLSAGVER VILGSSAVSNPPFVKKMLKQYGEKIAIGLDARNGFVSTEGWLETSTLKATELGKELAN EGAEVFIFTDIATDGMLSGPNVKSTVELAKETGKSVIASGGVSSVADLEALARNEADG VSGAIIGKALYTNQFTLSEALERVKRK*" /label="hisA CDS" gene complement(3235431..3236168) /gene="hisA" /locus_tag="BSU_34880" /old_locus_tag="BSU34880" /label="hisA gene" CDS complement(3236165..3236803) /gene="hisH" /locus_tag="BSU_34890" /old_locus_tag="BSU34890" /EC_number="2.4.2.-" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:14585832, 15301532" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14585832, 15301532; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="imidazole glycerol phosphate synthase, glutamineamidotransferase subunit" /protein_id="NP_391369.1" /db_xref="EnsemblGenomes-Gn:BSU34890" /db_xref="EnsemblGenomes-Tr:CAB15494" /db_xref="GOA:O34565" /db_xref="InterPro:IPR010139" /db_xref="InterPro:IPR017926" /db_xref="InterPro:IPR029062" /db_xref="SubtiList:BG12602" /db_xref="UniProtKB/Swiss-Prot:O34565" /translation="MIGVIDYGMGNLYSVSKALERVGVPYFVSEKPEELKEADAFILP GVGSFGDAMDNLGYTKLDQLIHDMVSEGRLLLGICLGMQLLFEESEENGTASGLGLLK GKAVRLKAEDEKGNKLKVPHMGWNRLSFHNESPLLTKTEQGYAYFVHSYYIDGMEENA LLASADYGVRVPAVVGKRNVFGAQFHPEKSSTVGMSILTQFTKMAAEQKVKK*" /label="hisH CDS" gene complement(3236165..3236803) /gene="hisH" /locus_tag="BSU_34890" /old_locus_tag="BSU34890" /label="hisH gene" promotor_no_box 3236661..3236761 /Source="Nicolas_upshift_promotors" /id="U2736" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.973026973026973" /psig="0.000999000999001" /xcortree=24 /SigmaFactorBS="gaaccgactcccggcaaaatgaaagcatcagcttctttcagc tcctccggcttttcagaaacaaaatacggcacgccgacacgttcaagcgcctttgaga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 3236721 /Source="Nicolas_upshifts" /id="U2736" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.973026973026973" /psig="0.000999000999001" /xcortree=24 /SigmaFactorBS="gaaccgactcccggcaaaatgaaagcatcagcttctttcagc tcctccggcttttcagaaacaaaatacggcacgccgacacgttcaagcgcctttgaga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3236804..3237388) /gene="hisB" /locus_tag="BSU_34900" /old_locus_tag="BSU34900" /EC_number="4.2.1.19" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1400209, 24311587; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="imidazoleglycerol-phosphate dehydratase [Mn(II)-dependent]" /protein_id="NP_391370.1" /db_xref="EnsemblGenomes-Gn:BSU34900" /db_xref="EnsemblGenomes-Tr:CAB15495" /db_xref="GOA:O34683" /db_xref="InterPro:IPR000807" /db_xref="InterPro:IPR020565" /db_xref="InterPro:IPR020568" /db_xref="SubtiList:BG12598" /db_xref="UniProtKB/Swiss-Prot:O34683" /translation="MRKAERVRKTNETDIELAFTIDGGGQADIKTDVPFMTHMLDLFT KHGQFDLSINAKGDVDIDDHHTTEDIGICLGQALLEALGDKKGIKRYGSAFVPMDEAL AQVVIDLSNRPHLEMRADFPAAKVGTFDTELVHEFLWKLALEARMNLHVIVHYGTNTH HMIEAVFKALGRALDEATTIDPRVKGIPSTKGML*" /label="hisB CDS" gene complement(3236804..3237388) /gene="hisB" /locus_tag="BSU_34900" /old_locus_tag="BSU34900" /label="hisB gene" CDS complement(3237385..3238668) /gene="hisD" /locus_tag="BSU_34910" /old_locus_tag="BSU34910" /EC_number="1.1.1.23" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10353847, 10353848, 21672513, 24140957; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="histidinol dehydrogenase" /protein_id="NP_391371.1" /db_xref="EnsemblGenomes-Gn:BSU34910" /db_xref="EnsemblGenomes-Tr:CAB15496" /db_xref="GOA:O34651" /db_xref="InterPro:IPR001692" /db_xref="InterPro:IPR012131" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR022695" /db_xref="SubtiList:BG12599" /db_xref="UniProtKB/Swiss-Prot:O34651" /translation="MKIKTISGAERLSLKRSIDAGTEEQRKTVRSIIEDVKANGDQAV RSYTAKFDCIEIDSPLVTKEEFEEAYTSLDSRLLQVIRQAIENIREYHERQLQSSWFY HRKDGTMLGQKVTALDSAGVYVPGGTAAYPSSVLMNVIPALVAGVERIVLVTPPGKDG LLSPGVLVAAAELGIKDIYKMGGAQAIAALAYGTETIEPVDKITGPGNIYVALAKREV FGDVDIDMIAGPSEIVVLADETAIPSEIAADLLSQAEHDKLSSCVFVTDSMALAETVS AEVNKQLETLPRREIAEASVRDYGCIYVAETMVEAIETVNTLAPEHLEIITQSPEALL GSIKHAGAIFLGRYSPEPVGDYFAGPNHVLPTNGTARFSSPLNVTDFQKKSSIISYSQ SAFEEHAESIAAFARLEGLEAHARSIEARERRISK*" /label="hisD CDS" gene complement(3237385..3238668) /gene="hisD" /locus_tag="BSU_34910" /old_locus_tag="BSU34910" /label="hisD gene" CDS complement(3238665..3239306) /gene="hisG" /locus_tag="BSU_34920" /old_locus_tag="BSU34920" /EC_number="2.4.2.17" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10430882, 12269828, 12511575, 14741209, 15660995, 17154531, 21774583, 22989207, 28092443, 28872824; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP phosphoribosyltransferase" /protein_id="NP_391372.1" /db_xref="EnsemblGenomes-Gn:BSU34920" /db_xref="EnsemblGenomes-Tr:CAB15497" /db_xref="GOA:O34520" /db_xref="InterPro:IPR001348" /db_xref="InterPro:IPR013820" /db_xref="InterPro:IPR018198" /db_xref="InterPro:IPR024893" /db_xref="PDB:2VD2" /db_xref="SubtiList:BG12601" /db_xref="UniProtKB/Swiss-Prot:O34520" /translation="MGKLLTMAMPKGRIFEEAAGLLRQAGYRLPEEFEDSRKLIIDVP EENLRFILAKPMDVTTYVEHGVADVGIAGKDVMLEEERDVYEVLDLNISKCHLAVAGL PNTDWSGVAPRIATKYPNVASSYFREQGEQVEIIKLNGSIELAPLIGLADRIVDIVST GQTLKENGLVETEHICDITSRFIVNPVSYRMKDDVIDEMASRLSLVVEGETAK*" /label="hisG CDS" gene complement(3238665..3239306) /gene="hisG" /locus_tag="BSU_34920" /old_locus_tag="BSU34920" /label="hisG gene" CDS complement(3239299..3240474) /gene="hisZ" /locus_tag="BSU_34930" /old_locus_tag="BSU34930" /EC_number="2.4.2.17" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10430882, 12269828, 12511575, 15660995; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="histidyl-tRNA synthetase-like subunit of ATP phophoribosyltransferase" /protein_id="NP_391373.1" /db_xref="EnsemblGenomes-Gn:BSU34930" /db_xref="EnsemblGenomes-Tr:CAB15498" /db_xref="GOA:O34459" /db_xref="InterPro:IPR004516" /db_xref="InterPro:IPR004517" /db_xref="InterPro:IPR006195" /db_xref="SubtiList:BG12606" /db_xref="UniProtKB/Swiss-Prot:O34459" /translation="MFMFEKPHGMRDTLPGLYETKKKVRRSLTDLIDKWGYQFMETPT LEFYDTVGVQSAIEEQQLFKLLDQDGKTLVLRPDMTGPIARVAASKLLKHGHPLRVGY AANVFRAQEREGGRPAEFEQVGVELIGDGTTSADAEVIALVVGALKNAGLASFKIAIG HAGIADALFVEVLGNVERADVLRRFLYEKNYVGYREHVKSLPLSSIDKSRLLELLELR GGIEVCGRAEEIVDSAQGKSVVDELKALWDILEDYGCTENVRLDLNMVSHMSYYTGIL FEVYAENVGFVIGSGGRYNKLLGHFDSPAPATGFGLRIDRLIEALHMKDEPCEIDAVI FSKEQRAQAIAYANEERMKGNKVVLQDLSGIENIDQMTKSFANVTYFIGARKEEQNG* " /label="hisZ CDS" gene complement(3239299..3240474) /gene="hisZ" /locus_tag="BSU_34930" /old_locus_tag="BSU34930" /label="hisZ gene" S_feature complement(3240475..3240552) /Source="Nicolas_S_feature" /locus_tag="new_3589361_3589438_c" /HighExp="Diami, M/G, Etha, BMM, MG 15, MG 10, T-1.10H, T-0.40H, T-1.40H, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1332" promotor_-35 3240518..3240524 /Source="Nicolas_upshift_promotors" /id="U2737" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.956043956043956" /psig="0.995004995004995" /xcortree=2775 /SigmaFactorBS="ccgctgttatcttatgaaggaaaattccgAATCCTTtagttc gctaaTATGATAATATGTTAGCAGAtgaaagaatgaaaatcaacgcttaacttcagta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3240536..3240555 /Source="Nicolas_upshift_promotors" /id="U2737" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.956043956043956" /psig="0.995004995004995" /xcortree=2775 /SigmaFactorBS="ccgctgttatcttatgaaggaaaattccgAATCCTTtagttc gctaaTATGATAATATGTTAGCAGAtgaaagaatgaaaatcaacgcttaacttcagta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(3240536..3240555) /Source="Nicolas_upshift_promotors" /id="U2738" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.486513486513487" /psig=1 /xcortree=2777 /SigmaFactorBS="ggatatttgaactaaaaatatccttactgaagttaagCGTTG ATTttcattctttcaTCTGCTAACATATTATCATAttagcgaactaaaggattcggaa t" /listShort="S1332, hisZ, hisG, hisD, hisB, hisH, hisA, hisF, hisI, S1331, S1330, yvcA, yvcB, yvzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3240549 /Source="Nicolas_upshifts" /id="U2737" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.956043956043956" /psig="0.995004995004995" /xcortree=2775 /SigmaFactorBS="ccgctgttatcttatgaaggaaaattccgAATCCTTtagttc gctaaTATGATAATATGTTAGCAGAtgaaagaatgaaaatcaacgcttaacttcagta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(3240552) /Source="Nicolas_upshifts" /id="U2738" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.486513486513487" /psig=1 /xcortree=2777 /SigmaFactorBS="ggatatttgaactaaaaatatccttactgaagttaagCGTTG ATTttcattctttcaTCTGCTAACATATTATCATAttagcgaactaaaggattcggaa t" /listShort="S1332, hisZ, hisG, hisD, hisB, hisH, hisA, hisF, hisI, S1331, S1330, yvcA, yvcB, yvzA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3240568..3240575) /Source="Nicolas_upshift_promotors" /id="U2738" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.486513486513487" /psig=1 /xcortree=2777 /SigmaFactorBS="ggatatttgaactaaaaatatccttactgaagttaagCGTTG ATTttcattctttcaTCTGCTAACATATTATCATAttagcgaactaaaggattcggaa t" /listShort="S1332, hisZ, hisG, hisD, hisB, hisH, hisA, hisF, hisI, S1331, S1330, yvcA, yvcB, yvzA" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 3240684..3240703 /Source="Nicolas_upshift_promotors" /id="U2739" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2160 /SigmaFactorBS="aatcatgaataatgtattaaaggtacgtaatatctcaaattc tttatgtttggCATGCTATAATACAAATCAAatagagaacaaggagataaagatgaaa a" /listShort="yvpB, S1333, pelC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3240691 /Source="Nicolas_upshifts" /id="U2739" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2160 /SigmaFactorBS="aatcatgaataatgtattaaaggtacgtaatatctcaaattc tttatgtttggCATGCTATAATACAAATCAAatagagaacaaggagataaagatgaaa a" /listShort="yvpB, S1333, pelC" /GFF_Attribute="listLong" /label="upshifts" CDS 3240725..3241477 /gene="yvpB" /locus_tag="BSU_34940" /old_locus_tag="BSU34940" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydratase" /protein_id="NP_391374.1" /db_xref="EnsemblGenomes-Gn:BSU34940" /db_xref="EnsemblGenomes-Tr:CAB15499" /db_xref="InterPro:IPR016997" /db_xref="SubtiList:BG14130" /db_xref="UniProtKB/Swiss-Prot:O34735" /translation="MKTLRTLCVLMILSGVIFFGLKIDAKDIDIPFLNSLKKVVSDSD TDSAANSKKELKGSAKPLDVILYNQMDAPRLYNGCEVTSLAMVLNYAGYDVTKNTLAN QVATVPLTYSSGLKGDPNDGFVGDMANGPGLGVYHRPIYQLAKTYAGDKVSDLTGKSI SAVYQQLEKGNPVWVITTANFTPVDNMQTWKTPNGTIEITYSEHSVAVTGYDDKYVYL NDPYGYKNRKTDRTSFEKAWKQMGSQAVVIQK*" /label="yvpB CDS" gene 3240725..3241477 /gene="yvpB" /locus_tag="BSU_34940" /old_locus_tag="BSU34940" /label="yvpB gene" S_feature 3241478..3241716 /Source="Nicolas_S_feature" /locus_tag="new_3590364_3590602" /HighExp="LBGstat, LPhT, Cold, Sw, M/G, G180, G135, LBGtran, G150, M40t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1333" promotor_-10 complement(3241499..3241510) /Source="Nicolas_upshift_promotors" /id="U2740" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=820 /SigmaFactorBS="ggaaaatgaatcgatcttaccgattgatacaaaaAGCATGAa tattgtcgtatttGCTCAGAATAGAgcatagtgaggcttcaggtgtttacttttgaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3241505) /Source="Nicolas_upshifts" /id="U2740" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=820 /SigmaFactorBS="ggaaaatgaatcgatcttaccgattgatacaaaaAGCATGAa tattgtcgtatttGCTCAGAATAGAgcatagtgaggcttcaggtgtttacttttgaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3241525..3241531) /Source="Nicolas_upshift_promotors" /id="U2740" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=820 /SigmaFactorBS="ggaaaatgaatcgatcttaccgattgatacaaaaAGCATGAa tattgtcgtatttGCTCAGAATAGAgcatagtgaggcttcaggtgtttacttttgaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3241717..3242382 /gene="pelC" /locus_tag="BSU_34950" /old_locus_tag="BSU34950" /EC_number="4.2.2.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10658655, 15187182, 16514142, 20000851, 24236123" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10658655, 15187182, 16514142, 20000851, 24236123; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="secreted pectate (polygalacturonate) lyase" /protein_id="NP_391375.1" /db_xref="EnsemblGenomes-Gn:BSU34950" /db_xref="EnsemblGenomes-Tr:CAB15500" /db_xref="GOA:O34310" /db_xref="InterPro:IPR004898" /db_xref="InterPro:IPR011050" /db_xref="InterPro:IPR012334" /db_xref="SubtiList:BG14129" /db_xref="UniProtKB/Swiss-Prot:O34310" /translation="MKKIVSILFMFGLVMGFSQFQPSTVFAADKVVHETIIVPKNTTY DGKGQRFVAGKELGDGSQSENQDPVFRVEDGATLKNVVLGAPAADGVHTYGNVNIQNV KWEDVGEDALTVKKEGKVTIDGGSAQKASDKIFQINKASTFTVKNFTADNGGKFIRQL GGSTFHVDVIIDKCTITNMKEAIFRTDSKTSTVRMTNTRYSNVGQKWIGVQHIYENNN TQF*" /label="pelC CDS" gene 3241717..3242382 /gene="pelC" /locus_tag="BSU_34950" /old_locus_tag="BSU34950" /label="pelC gene" downshifts 3242353 /Source="Nicolas_upshifts" /id="D1809" /incds=0 /nref=85 /ntot=213 /MaxReadThrough="1.40389" /MaxDrop="4.93342" /score="16.0973385" /energy="-14.9" /TU="NA" /idTUdmin="U2739" /TUdmin=176 /isTUend="FALSE" /label="downshifts" CDS complement(3242402..3242920) /gene="hprF" /locus_tag="BSU_34960" /old_locus_tag="BSU34960" /EC_number="2.3.1.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:21761520, 27226549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21761520, 27226549; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dephosphorylated heptaprenylglyceryl phosphate O-acetyltransferase" /protein_id="NP_391376.1" /db_xref="EnsemblGenomes-Gn:BSU34960" /db_xref="EnsemblGenomes-Tr:CAB15501" /db_xref="GOA:O34993" /db_xref="InterPro:IPR001451" /db_xref="InterPro:IPR011004" /db_xref="SubtiList:BG14128" /db_xref="UniProtKB/Swiss-Prot:O34993" /translation="MRKTDRHPVSGANSLWHVYQTVPFLKVVKNFIVIQIARYTPFIG MKNWLYRTFLRMKVGKQTSFALMVMPDIMFPEKISVGTNTIIGYNTTILAHEYLIHEY RIGKVLIGDEVMIGANTTILPGVKIGDGAVVSAGTLVHKDVPDGAFVGGNPMRIIYTK EEMQERLKKSAE*" /label="hprF CDS" gene complement(3242402..3242920) /gene="hprF" /locus_tag="BSU_34960" /old_locus_tag="BSU34960" /label="hprF gene" downshifts complement(3242436) /Source="Nicolas_upshifts" /id="D1810" /incds=0 /nref=245 /ntot=283 /MaxReadThrough="1.27998" /MaxDrop="6.44997" /score="38.2106579" /energy="-14.9" /TU="NA" /idTUdmin="U2741" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" CDS complement(3242924..3243574) /gene="ppaX" /locus_tag="BSU_34970" /old_locus_tag="BSU34970" /EC_number="3.6.1.1" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9465101, 12359880, 12411438, 16182622, 22353596" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9465101, 12359880, 12411438, 16182622, 22353596; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="Hpr-associated pyrophosphatase" /protein_id="NP_391377.1" /db_xref="EnsemblGenomes-Gn:BSU34970" /db_xref="EnsemblGenomes-Tr:CAB15502" /db_xref="GOA:Q9JMQ2" /db_xref="InterPro:IPR006439" /db_xref="InterPro:IPR023198" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR023733" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG14127" /db_xref="UniProtKB/Swiss-Prot:Q9JMQ2" /translation="MSDKQVTTILFDLDGTLINTNELIIASFLHTLEHYYPSKYKRED VLAFIGPSLFDTFSSMDPDKCEDMIAMYRAYNHDMHDSLVTEYETVYETLDALKKAGF TLGIVTTKLRDTVNMGLKLTGIGEFFETVVTLDDVTNAKPDPEPVLLALKQLGSEPAE AIMVGDNYHDVLAGKNAGTKTAGVAWTIKGPEMLAKHEPDFMLEKMSDLLQIVGVK*" /label="ppaX CDS" gene complement(3242924..3243574) /gene="ppaX" /locus_tag="BSU_34970" /old_locus_tag="BSU34970" /label="ppaX gene" CDS complement(3243571..3244509) /gene="yvoD" /locus_tag="BSU_34980" /old_locus_tag="BSU34980" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 27226549; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein with nucleotide binding domain" /protein_id="NP_391378.1" /db_xref="EnsemblGenomes-Gn:BSU34980" /db_xref="EnsemblGenomes-Tr:CAB15503" /db_xref="GOA:O34382" /db_xref="InterPro:IPR011642" /db_xref="SubtiList:BG14126" /db_xref="UniProtKB/Swiss-Prot:O34382" /translation="MKKIFLAGLAAGFQTTWTLGKVIFPVTLLVTLLQHTPVMDWLVR LITPVMGLFGLSGEAAIPLVLGNMLNLYAGIAGILTLDLSVKEVFILAVMLSFCHNLI IESTVAAKVGIRIGVILAVRIGLAAVSAIVINLIWHGGKETAQYGFIAAKSAAPDSWL GMLAEALTKAGLGVLQLAAIVIPLMIIIQFLRDLGWLYRFSRWLSPFTQLLGMNKNTS MTMVTGLTIGLAYGAGVMIKAVEDDGVSKRDMTLAFIFLVACHAVVEDTLVFIPLGIP VWPLLLIRVTTAVLLTMAIAHTWKKWKPSAVGKEAI*" /label="yvoD CDS" gene complement(3243571..3244509) /gene="yvoD" /locus_tag="BSU_34980" /old_locus_tag="BSU34980" /label="yvoD gene" CDS complement(3244533..3245342) /gene="lgt" /locus_tag="BSU_34990" /old_locus_tag="BSU34990" /EC_number="2.4.99.-" /function="16.5: Explore" /function="16.13: Shape" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:10096076, 11425480, 15126458, 15849754, 16850406, 18556788, 27226549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10096076, 11425480, 15126458, 15849754, 16850406, 18556788, 27226549; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="prelipoprotein diacylglycerol transferase" /protein_id="NP_391379.1" /db_xref="EnsemblGenomes-Gn:BSU34990" /db_xref="EnsemblGenomes-Tr:CAB15504" /db_xref="GOA:O34752" /db_xref="InterPro:IPR001640" /db_xref="SubtiList:BG12611" /db_xref="UniProtKB/Swiss-Prot:O34752" /translation="MNEAIEPLNPIAFQLGPLAVHWYGIIIGLGALLGLWIAMRESEK RGLQKDTFIDLVLFAIPIAIICARIYYVAFEWDYYAAHPGEIIKIWKGGIAIHGGLIG AILTGYVFSRVKNLSFWKLADIAAPSILLGQAIGRWGNFMNQEAHGEAVSRAFLENLH LPEFIINQMYINGQYYHPTFLYESLWSFVGVIVLLLLRRANLRRGEMFLIYIIWYSIG RYFIEGMRTDSLMLTDSLRIAQVISIVLIVLAVAAIIFRRVKGYSKERYAE*" /label="lgt CDS" gene complement(3244533..3245342) /gene="lgt" /locus_tag="BSU_34990" /old_locus_tag="BSU34990" /label="lgt gene" CDS complement(3245356..3246288) /gene="hprK" /locus_tag="BSU_35000" /old_locus_tag="BSU35000" /EC_number="2.7.4.-" /EC_number="2.7.11.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10636874, 12009882, 12359875, 12411438, 12779331, 15023355, 16267306, 17878158, 20487301, 21992469, 27226549" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10636874, 12009882, 12359875, 12411438, 12779331, 15023355, 16267306, 17878158, 20487301, 21992469, 27226549; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="serine/threonine protein kinase/phosphorylase (pyrophosphate-producing)" /protein_id="NP_391380.1" /db_xref="EnsemblGenomes-Gn:BSU35000" /db_xref="EnsemblGenomes-Tr:CAB15505" /db_xref="GOA:O34483" /db_xref="InterPro:IPR003755" /db_xref="InterPro:IPR011104" /db_xref="InterPro:IPR011126" /db_xref="InterPro:IPR028979" /db_xref="SubtiList:BG14125" /db_xref="UniProtKB/Swiss-Prot:O34483" /translation="MAKVRTKDVMEQFNLELISGEEGINRPITMSDLSRPGIEIAGYF TYYPRERVQLLGKTELSFFEQLPEEEKKQRMDSLCTDVTPAIILSRDMPIPQELIDAS EKNGVPVLRSPLKTTRLSSRLTNFLESRLAPTTAIHGVLVDIYGVGVLITGKSGVGKS ETALELVKRGHRLVADDCVEIRQEDQDTLVGNAPELIEHLLEIRGLGIINVMTLFGAG AVRSNKRITIVMNLELWEQGKQYDRLGLEEETMKIIDTEITKLTIPVRPGRNLAVIIE VAAMNFRLKRMGLNAAEQFTNKLADVIEDGEQEE*" /label="hprK CDS" gene complement(3245356..3246288) /gene="hprK" /locus_tag="BSU_35000" /old_locus_tag="BSU35000" /label="hprK gene" promotor_-10 complement(3246330..3246349) /Source="Nicolas_upshift_promotors" /id="U2741" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.518481518481518" /psig="0.998001998001998" /xcortree=2677 /SigmaFactorBS="ggtgttttccccccttttataaaatcTGTTTTaggttcaagc ccgaaAGTGATAAAATGAAAGTATTgtgagcaagctcggggcagcccggaacaggagg a" /listShort="hprK, lgt, yvoD, ppaX, yvoF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3246336) /Source="Nicolas_upshifts" /id="U2741" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.518481518481518" /psig="0.998001998001998" /xcortree=2677 /SigmaFactorBS="ggtgttttccccccttttataaaatcTGTTTTaggttcaagc ccgaaAGTGATAAAATGAAAGTATTgtgagcaagctcggggcagcccggaacaggagg a" /listShort="hprK, lgt, yvoD, ppaX, yvoF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3246365..3246370) /Source="Nicolas_upshift_promotors" /id="U2741" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.518481518481518" /psig="0.998001998001998" /xcortree=2677 /SigmaFactorBS="ggtgttttccccccttttataaaatcTGTTTTaggttcaagc ccgaaAGTGATAAAATGAAAGTATTgtgagcaagctcggggcagcccggaacaggagg a" /listShort="hprK, lgt, yvoD, ppaX, yvoF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3246405..3246412 /Source="Nicolas_upshift_promotors" /id="U2742" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.664335664335664" /psig="0.997002997002997" /xcortree=2396 /SigmaFactorBS="taaaacagattttataaaaggggggaaaacacctcagctggT CTAGATCactagtctgaaaaaGAGTAAAATAAAGGTATTcaaattccagaaaggcgga t" /listShort="nagA, nagBA, yvoA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3246424 /Source="Nicolas_upshifts" /id="U2742" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.664335664335664" /psig="0.997002997002997" /xcortree=2396 /SigmaFactorBS="taaaacagattttataaaaggggggaaaacacctcagctggT CTAGATCactagtctgaaaaaGAGTAAAATAAAGGTATTcaaattccagaaaggcgga t" /listShort="nagA, nagBA, yvoA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3246427..3246444 /Source="Nicolas_upshift_promotors" /id="U2742" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.664335664335664" /psig="0.997002997002997" /xcortree=2396 /SigmaFactorBS="taaaacagattttataaaaggggggaaaacacctcagctggT CTAGATCactagtctgaaaaaGAGTAAAATAAAGGTATTcaaattccagaaaggcgga t" /listShort="nagA, nagBA, yvoA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3246470..3247660 /gene="nagA" /locus_tag="BSU_35010" /old_locus_tag="BSU35010" /EC_number="3.5.1.25" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:6774970, 14557261, 21602348" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 6774970, 14557261, 21602348; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylglucosamine-6-phosphate deacetylase" /protein_id="NP_391381.1" /db_xref="EnsemblGenomes-Gn:BSU35010" /db_xref="EnsemblGenomes-Tr:CAB15506" /db_xref="GOA:O34450" /db_xref="InterPro:IPR003764" /db_xref="InterPro:IPR006680" /db_xref="InterPro:IPR011059" /db_xref="InterPro:IPR032466" /db_xref="PDB:2VHL" /db_xref="SubtiList:BG12630" /db_xref="UniProtKB/Swiss-Prot:O34450" /translation="MAESLLIKDIAIVTENEVIKNGYVGINDGKISTVSTERPKEPYS KEIQAPADSVLLPGMIDIHIHGGYGADTMDASFSTLDIMSSRLPEEGTTSFLATTITQ EHGNISQALVNAREWKAAEESSLLGAELLGIHLEGPFVSPKRAGAQPKEWIRPSDVEL FKKWQQEAGGLIKIVTLAPEEDQHFELIRHLKDESIIASMGHTDADSALLSDAAKAGA SHMTHLYNAMSPFHHREPGVIGTALAHDGFVTELIADGIHSHPLAAKLAFLAKGSSKL ILITDSMRAKGLKDGVYEFGGQSVTVRGRTALLSDGTLAGSILKMNEGARHMREFTNC SWTDIANITSENAAKQLGIFDRKGSVTVGKDADLVIVSSDCEVILTICRGNIAFISKE ADQI*" /label="nagA CDS" gene 3246470..3247660 /gene="nagA" /locus_tag="BSU_35010" /old_locus_tag="BSU35010" /label="nagA gene" promotor_-35 3247458..3247464 /Source="Nicolas_upshift_promotors" /id="U2743" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=172 /SigmaFactorBS="cgatcctcaaaatgaacgaaggcgcacggcatatgcgtgAGT TTACaaattgctcttggacGGATATAGCTAATATAACTtctgaaaacgcggccaaaca g" /listShort="nagBA, yvoA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3247479 /Source="Nicolas_upshifts" /id="U2743" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=172 /SigmaFactorBS="cgatcctcaaaatgaacgaaggcgcacggcatatgcgtgAGT TTACaaattgctcttggacGGATATAGCTAATATAACTtctgaaaacgcggccaaaca g" /listShort="nagBA, yvoA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3247480..3247498 /Source="Nicolas_upshift_promotors" /id="U2743" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=172 /SigmaFactorBS="cgatcctcaaaatgaacgaaggcgcacggcatatgcgtgAGT TTACaaattgctcttggacGGATATAGCTAATATAACTtctgaaaacgcggccaaaca g" /listShort="nagBA, yvoA" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3247657..3248385 /gene="nagBA" /locus_tag="BSU_35020" /old_locus_tag="BSU35020" /EC_number="3.5.99.6" /function="16.2: Construct biomass (Anabolism)" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15755726, 18436239" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15755726, 18436239; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucosamine-6-phosphate isomerase" /protein_id="NP_391382.1" /db_xref="EnsemblGenomes-Gn:BSU35020" /db_xref="EnsemblGenomes-Tr:CAB15507" /db_xref="GOA:O35000" /db_xref="InterPro:IPR004547" /db_xref="InterPro:IPR006148" /db_xref="InterPro:IPR018321" /db_xref="PDB:2BKV" /db_xref="PDB:2BKX" /db_xref="SubtiList:BG12631" /db_xref="UniProtKB/Swiss-Prot:O35000" /translation="MKVMECQTYEELSQIAARITADTIKEKPDAVLGLATGGTPEGTY RQLIRLHQTENLSFQNITTVNLDEYAGLSSDDPNSYHFYMNDRFFQHIDSKPSRHFIP NGNADDLEAECRRYEQLVDSLGDTDIQLLGIGRNGHIGFNEPGTSFKSRTHVVTLNEQ TRQANARYFPSIDSVPKKALTMGIQTILSSKRILLLISGKSKAEAVRKLLEGNISEDF PASALHLHSDVTVLIDREAASLRP*" /label="nagBA CDS" gene 3247657..3248385 /gene="nagBA" /locus_tag="BSU_35020" /old_locus_tag="BSU35020" /label="nagBA gene" CDS 3248403..3249134 /gene="nagR" /locus_tag="BSU_35030" /old_locus_tag="BSU35030" /experiment="publication(s) with functional evidences, PMID:16207374, 20047956, 21602348, 23667565, 24673833, 26162881" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16207374, 20047956, 21602348, 23667565, 24673833, 26162881; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (GntR family)" /protein_id="NP_391383.1" /db_xref="EnsemblGenomes-Gn:BSU35030" /db_xref="EnsemblGenomes-Tr:CAB15508" /db_xref="GOA:O34817" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR011663" /db_xref="InterPro:IPR028978" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:2WV0" /db_xref="PDB:4U0V" /db_xref="PDB:4U0W" /db_xref="PDB:4U0Y" /db_xref="PDB:4WWC" /db_xref="SubtiList:BG14124" /db_xref="UniProtKB/Swiss-Prot:O34817" /translation="MNINKQSPIPIYYQIMEQLKTQIKNGELQPDMPLPSEREYAEQF GISRMTVRQALSNLVNEGLLYRLKGRGTFVSKPKMEQALQGLTSFTEDMKSRGMTPGS RLIDYQLIDSTEELAAILGCGHPSSIHKITRVRLANDIPMAIESSHIPFELAGELNES HFQSSIYDHIERYNSIPISRAKQELEPSAATTEEANILGIQKGAPVLLIKRTTYLQNG TAFEHAKSVYRGDRYTFVHYMDRLS*" /label="nagR CDS" gene 3248403..3249134 /gene="nagR" /locus_tag="BSU_35030" /old_locus_tag="BSU35030" /label="nagR gene" CDS complement(3249154..3253023) /gene="yvnB" /locus_tag="BSU_35040" /old_locus_tag="BSU35040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 27542896; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative exported hydrolase" /protein_id="NP_391384.1" /db_xref="EnsemblGenomes-Gn:BSU35040" /db_xref="EnsemblGenomes-Tr:CAB15509" /db_xref="GOA:O34986" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR011401" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR029052" /db_xref="InterPro:IPR036415" /db_xref="SubtiList:BG14123" /db_xref="UniProtKB/Swiss-Prot:O34986" /translation="MRKYTVIASILLSFLSVLSGGHHESKAFPVVQQELFQTPHYIPL LENPPQIDVKAEMRSNLMIEAQVRDNSYQAFSAFLFYKQSNELGYKMVPMDPTPGAVR KFLAQIPKRLIWNSELEYYIVMSNGKQRVESETKKLKLEGYQADLAHIPELLITELAV DTKNIGRADGYEFIEIFNTTDRTIDFKDYHIRYRYPKEGPDSDLIWRPDERILIPSGE TFVVWLKPAGHPELTSADFNRYYQTQLKEGKNLAVIDETEGMANTRPRAVVISTNTGK DISVAHYRKHALRRLSSVLYKYPLNGTAELLNISIGEKNPSPGTVLQAQVPDQKRKIK LDKEKPVIEDLTDRKPVRPAESIELRADIRDRSLVKTVAFYYRTDENKPFKRILAEKD RNDNLFHYIVYSPELIGKDQLEYYVAAGDGINEARTPVKMIDIKQTSKAHGLRMNIEN RDTLSGTQFLKATTEGRADSIKLWIDGKKQVTEPAMEKEVYFAFDTRKTNLYFKNAVT MEGKVLKVFDDTTNKYRTYSVPLPETLLRKGKQLQRITIRSGSKVSPFDTAENRDDFL VKNARLVLSDGTVIRDQRVSPEKELFIGDNQRSNKSWQFQFNLPDGLFTSQLLEWDTS KLSEGAHHIQASDGKENVSLVVRVDNSGPHIEPNITEGQTYKGNLILQADMYDKWSRI EEAEASLDGESITLPYHTSSSDLLPGKHSLKVTATDLAGNKTVIERIFKTEREHPDQP EVIDSEADTHKAKLSVRVKDPTNDAMDVGFYRGFQYTARNHVKIFKHASLTEPPKSFV PERETPFTNKELERVSAADGKTVSTENKELFPYHRFEVTVDPSIDENDLAESVWKGSS LPGRKVTMYAWNYRTNEWQPVDSFVAKDDKPFTLKASVIAADFVRESKMNVIVQDEIP PAKDMYTFVWMSDTQYYAESYPHIFDKQTEWIKDNQKQLNIKYVFHTGDIVDDSADIR QWKNADRSMSVLDKSGIPYGVLAGNHDVGHKDGSYRAFGKYFGSDRFDKKFHYGGSYK NNRGHYDLISSNGNDYIMLYMGWGITDEDIAWMNQVLKKHPDRMAILAFHEYLLVSGN RSPIGEKIFKEIVKPNPNVVMVLSGHYHSAMRKTDELDDDGDGKPDRLVHQMLADYQG GPEGGQGYLRLLQFDQANDMVHVSTYSPYVKDKNYYDTDTYGNKDEFSLSLDLKPRIK KVETDYFECNVYTNEELGKREQVKSGDTAEFRWDHLEPQSVYYWYIIVEDSFNGKTKS PIWKFKTKKETYRPAPDQFDFRHVSNP*" /label="yvnB CDS" gene complement(3249154..3253023) /gene="yvnB" /locus_tag="BSU_35040" /old_locus_tag="BSU35040" /label="yvnB gene" downshifts complement(3249276) /Source="Nicolas_upshifts" /id="D1811" /incds=1 /nref=19 /ntot=109 /MaxReadThrough="1.28942" /MaxDrop="4.39575" /score="28.0438848" /energy="-16.5" /TU="NA" /idTUdmin="U2744" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3253043..3253054) /Source="Nicolas_upshift_promotors" /id="U2744" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=878 /SigmaFactorBS="cagacgtttttttgttctttatgcacaaaaatgaaCTCATAA gcttccctgttcagACGCAAAATACAtgaaaagggaggtgctttgatgaggaaataca c" /listShort="yvnB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3253050) /Source="Nicolas_upshifts" /id="U2744" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=878 /SigmaFactorBS="cagacgtttttttgttctttatgcacaaaaatgaaCTCATAA gcttccctgttcagACGCAAAATACAtgaaaagggaggtgctttgatgaggaaataca c" /listShort="yvnB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3253069..3253075) /Source="Nicolas_upshift_promotors" /id="U2744" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=878 /SigmaFactorBS="cagacgtttttttgttctttatgcacaaaaatgaaCTCATAA gcttccctgttcagACGCAAAATACAtgaaaagggaggtgctttgatgaggaaataca c" /listShort="yvnB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3253113..3253119 /Source="Nicolas_upshift_promotors" /id="U2745" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig=1 /xcortree=2922 /SigmaFactorBS="catttttgtgcataaagaacaaaaaaacgtctgtcTCTTGAA aattccactattaCCCAGTAAACTAAGGATAGTtaaccagttaacaattaaatcagag a" /listShort="yvnA, S1334, S1335" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3253133..3253152 /Source="Nicolas_upshift_promotors" /id="U2745" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig=1 /xcortree=2922 /SigmaFactorBS="catttttgtgcataaagaacaaaaaaacgtctgtcTCTTGAA aattccactattaCCCAGTAAACTAAGGATAGTtaaccagttaacaattaaatcagag a" /listShort="yvnA, S1334, S1335" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3253138 /Source="Nicolas_upshifts" /id="U2745" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.473526473526474" /psig=1 /xcortree=2922 /SigmaFactorBS="catttttgtgcataaagaacaaaaaaacgtctgtcTCTTGAA aattccactattaCCCAGTAAACTAAGGATAGTtaaccagttaacaattaaatcagag a" /listShort="yvnA, S1334, S1335" /GFF_Attribute="listLong" /label="upshifts" CDS 3253188..3253661 /gene="yvnA" /locus_tag="BSU_35050" /old_locus_tag="BSU35050" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_391385.1" /db_xref="EnsemblGenomes-Gn:BSU35050" /db_xref="EnsemblGenomes-Tr:CAB15510" /db_xref="GOA:O34692" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG14122" /db_xref="UniProtKB/Swiss-Prot:O34692" /translation="MDNSIHDELFQAIQQFALKRDKRVWQKVQIPSIGISSQHHDHLK KDWTLTQLHIVSCIHTSQNVNNSFLASRLHISKAAVSKAVHALLKHNIITVTKKPGNK KEIFYTLTDSGRKLAALHEQLHEKAKEQYKQLFNEFSIDDLKTVTAFFNLWIKYM*" /label="yvnA CDS" gene 3253188..3253661 /gene="yvnA" /locus_tag="BSU_35050" /old_locus_tag="BSU35050" /label="yvnA gene" S_feature 3253662..3253769 /Source="Nicolas_S_feature" /locus_tag="new_3602548_3602655" /HighExp="T5.0H, T4.0H, T3.30H, T3.0H, T2.30H, M9-stat, T2.0H, T1.30H, T1.0H, BC" /AntisenseName="cypX" /AntisenseCor="-1.1473096183385199E-3" /AntisenseRegPval=0 /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1334" CDS complement(3253702..3254919) /gene="cypX" /locus_tag="BSU_35060" /old_locus_tag="BSU35060" /EC_number="1.14.-.-" /function="16.5: Explore" /function="16.14: Store" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:4204912, 20690619, 27542896" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4204912, 20690619, 27542896; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cyclo-L-leucyl-L-leucyl dipeptide oxidase, pulcheriminic synthase" /protein_id="NP_391386.1" /db_xref="EnsemblGenomes-Gn:BSU35060" /db_xref="EnsemblGenomes-Tr:CAB15511" /db_xref="GOA:O34926" /db_xref="InterPro:IPR001128" /db_xref="InterPro:IPR002397" /db_xref="InterPro:IPR017972" /db_xref="InterPro:IPR030904" /db_xref="InterPro:IPR036396" /db_xref="PDB:3NC3" /db_xref="PDB:3NC5" /db_xref="PDB:3NC6" /db_xref="PDB:3NC7" /db_xref="SubtiList:BG12580" /db_xref="UniProtKB/Swiss-Prot:O34926" /translation="MSQSIKLFSVLSDQFQNNPYAYFSQLREEDPVHYEESIDSYFIS RYHDVRYILQHPDIFTTKSLVERAEPVMRGPVLAQMHGKEHSAKRRIVVRSFIGDALD HLSPLIKQNAENLLAPYLERGKSDLVNDFGKTFAVCVTMDMLGLDKRDHEKISEWHSG VADFITSISQSPEARAHSLWCSEQLSQYLMPVIKERRVNPGSDLISILCTSEYEGMAL SDKDILALILNVLLAATEPADKTLALMIYHLLNNPEQMNDVLADRSLVPRAIAETLRY KPPVQLIPRQLSQDTVVGGMEIKKDTIVFCMIGAANRDPEAFEQPDVFNIHREDLGIK SAFSGAARHLAFGSGIHNCVGAAFAKNEIEIVANIVLDKMRNIRLEEDFCYAESGLYT RGPVSLLVAFDGA*" /label="cypX CDS" gene complement(3253702..3254919) /gene="cypX" /locus_tag="BSU_35060" /old_locus_tag="BSU35060" /label="cypX gene" downshifts complement(3253715) /Source="Nicolas_upshifts" /id="D1812" /incds=0 /nref=11 /ntot=50 /MaxReadThrough="2.27112" /MaxDrop="6.67384" /score="-0.264310319" /energy="-11.6" /TU="NA" /idTUdmin="U2747" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 3253741..3253746 /Source="Nicolas_upshift_promotors" /id="U2746" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.437562437562438" /psig="0.437562437562438" /xcortree=409 /SigmaFactorBS="gtcaaacgcaacgagaagtgaaacaggtccGCGTGTatacag accggactCAGCATAACAAAaatcttcctctaatctgatattccgcatcttatccagc a" /listShort="S1335" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3253761..3253772 /Source="Nicolas_upshift_promotors" /id="U2746" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.437562437562438" /psig="0.437562437562438" /xcortree=409 /SigmaFactorBS="gtcaaacgcaacgagaagtgaaacaggtccGCGTGTatacag accggactCAGCATAACAAAaatcttcctctaatctgatattccgcatcttatccagc a" /listShort="S1335" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3253771..3254056 /Source="Nicolas_S_feature" /locus_tag="new_3602657_3602942" /HighExp="BC, Sw, Lbstat, T5.0H, M9-stat, T4.0H, T3.30H, B60, T1.30H, T0.30H" /AntisenseName="cypX" /AntisenseCor="-4.04991056466339E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.438, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1335" upshifts 3253771 /Source="Nicolas_upshifts" /id="U2746" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.437562437562438" /psig="0.437562437562438" /xcortree=409 /SigmaFactorBS="gtcaaacgcaacgagaagtgaaacaggtccGCGTGTatacag accggactCAGCATAACAAAaatcttcctctaatctgatattccgcatcttatccagc a" /listShort="S1335" /GFF_Attribute="listLong" /label="upshifts" downshifts 3254013 /Source="Nicolas_upshifts" /id="D1813" /incds=1 /nref=9 /ntot=165 /MaxReadThrough="3.27492" /MaxDrop="3.99509" /score="54.0406126" /energy="-11.4" /TU="U2745,U2746" /idTUdmin="U2746" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" CDS complement(3254935..3255681) /gene="pchC" /locus_tag="BSU_35070" /old_locus_tag="BSU35070" /EC_number="6.-.-.-" /function="16.14: Store" /function="16.1: Circulate" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:4204912, 19430487, 27542896" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4204912, 19430487, 27542896; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cyclodipeptide synthase (tRNA-dependent), pulcherimminic acid precursor" /protein_id="NP_391387.1" /db_xref="EnsemblGenomes-Gn:BSU35070" /db_xref="EnsemblGenomes-Tr:CAB15512" /db_xref="GOA:O34351" /db_xref="InterPro:IPR030903" /db_xref="SubtiList:BG14121" /db_xref="UniProtKB/Swiss-Prot:O34351" /translation="MTGMVTERRSVHFIAEALTENCREIFERRRHVLVGISPFNSRFS EDYIYRLIGWAKAQFKSVSVLLAGHEAANLLEALGTPRGKAERKVRKEVSRNRRFAER ALVAHGGDPKAIHTFSDFIDNKAYQLLRQEVEHAFFEQPHFRHACLDMSREAIIGRAR GVSLMMEEVSEDMLNLAVEYVIAELPFFIGAPDILEVEETLLAYHRPWKLGEKISNHE FSICMRPNQGYLIVQEMAQMLSEKRITSEG*" /label="pchC CDS" gene complement(3254935..3255681) /gene="pchC" /locus_tag="BSU_35070" /old_locus_tag="BSU35070" /label="pchC gene" S_feature complement(3255682..3255868) /Source="Nicolas_S_feature" /locus_tag="new_3604568_3604754_c" /HighExp="LBGstat, T1.30H, T2.0H, T2.30H, T3.0H, T1.0H, B36, BT, T3.30H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1336" promotor_-10 complement(3255854..3255873) /Source="Nicolas_upshift_promotors" /id="U2747" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.771228771228771" /psig=1 /xcortree=1627 /SigmaFactorBS="tacatttattttcaaatatttgggcacagatcatATTGACGT ttggaaggaaaagGGATAAAATGACTAATGTTTactagtaaacatttatcatgatatg g" /listShort="S1336, yvmC, cypX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3255868) /Source="Nicolas_upshifts" /id="U2747" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.771228771228771" /psig=1 /xcortree=1627 /SigmaFactorBS="tacatttattttcaaatatttgggcacagatcatATTGACGT ttggaaggaaaagGGATAAAATGACTAATGTTTactagtaaacatttatcatgatatg g" /listShort="S1336, yvmC, cypX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3255887..3255894) /Source="Nicolas_upshift_promotors" /id="U2747" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.771228771228771" /psig=1 /xcortree=1627 /SigmaFactorBS="tacatttattttcaaatatttgggcacagatcatATTGACGT ttggaaggaaaagGGATAAAATGACTAATGTTTactagtaaacatttatcatgatatg g" /listShort="S1336, yvmC, cypX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3256002..3256009 /Source="Nicolas_upshift_promotors" /id="U2748" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.571428571428571" /psig="0.998001998001998" /xcortree=1628 /SigmaFactorBS="tatcaacaaatagtctaaacaccaacAATTGACAacgaaaac aagaaaAGATAAAATAAAATTGTTCAccagtaaacgatttgttttattgtttcatcgt a" /listShort="S1337, yvmB, yvmA, S1339" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3256024..3256043 /Source="Nicolas_upshift_promotors" /id="U2748" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.571428571428571" /psig="0.998001998001998" /xcortree=1628 /SigmaFactorBS="tatcaacaaatagtctaaacaccaacAATTGACAacgaaaac aagaaaAGATAAAATAAAATTGTTCAccagtaaacgatttgttttattgtttcatcgt a" /listShort="S1337, yvmB, yvmA, S1339" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3256036 /Source="Nicolas_upshifts" /id="U2748" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.571428571428571" /psig="0.998001998001998" /xcortree=1628 /SigmaFactorBS="tatcaacaaatagtctaaacaccaacAATTGACAacgaaaac aagaaaAGATAAAATAAAATTGTTCAccagtaaacgatttgttttattgtttcatcgt a" /listShort="S1337, yvmB, yvmA, S1339" /GFF_Attribute="listLong" /label="upshifts" S_feature 3256037..3256106 /Source="Nicolas_S_feature" /locus_tag="new_3604923_3604992" /HighExp="LBGstat, T1.30H, T2.0H, T2.30H, T1.0H, T0.30H, B36, T3.0H, BT, Salt" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1337" CDS 3256107..3256616 /gene="pchR" /locus_tag="BSU_35080" /old_locus_tag="BSU35080" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:27542896" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 27542896; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator for pulcherriminic acid synthesis" /protein_id="NP_391388.1" /db_xref="EnsemblGenomes-Gn:BSU35080" /db_xref="EnsemblGenomes-Tr:CAB15513" /db_xref="GOA:P40762" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11018" /db_xref="UniProtKB/Swiss-Prot:P40762" /translation="MSDLTKQMIYDIYVRLLHLNEQKANTSLQQFFKEAAEEDVAEIP KNMTSIHVIDCIGQHEPINNAGIARKMNLSKANVTKISTKLIKEEFINSYQLTDNKKE VYFKLTRKGRRIFDLHEKLHKKKELAFYQFLDSFSQEEQKAVLKFLEQLTSTLEAEQT DGTPDKPVK*" /label="pchR CDS" gene 3256107..3256616 /gene="pchR" /locus_tag="BSU_35080" /old_locus_tag="BSU35080" /label="pchR gene" S_feature complement(3256512..3257850) /Source="Nicolas_S_feature" /locus_tag="new_3605398_3606736_c" /HighExp="T0.30H, T1.0H, T1.30H, T-0.40H, T0.0H, T2.0H, G135, T2.30H, T-1.10H, G180" /AntisenseName="yvmA" /AntisenseCor="0.2423954904641" /AntisenseRegPval="-4.2" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.993" /label="S1338" downshifts complement(3256553) /Source="Nicolas_upshifts" /id="D1814" /incds=1 /nref=1 /ntot=66 /MaxReadThrough="1.42525" /MaxDrop="2.72496" /score="14.1278884" /energy="-7.8" /TU="NA" /idTUdmin="U2749" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 3256637..3257848 /gene="pchE" /locus_tag="BSU_35090" /old_locus_tag="BSU35090" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 27542896" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 27542896; Product type t: transporter" /codon_start=1 /transl_table=11 /product="pulcherriminic acid efflux transporter" /protein_id="NP_391389.1" /db_xref="EnsemblGenomes-Gn:BSU35090" /db_xref="EnsemblGenomes-Tr:CAB15514" /db_xref="GOA:O34307" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG14120" /db_xref="UniProtKB/Swiss-Prot:O34307" /translation="MAHTKSKAVLILYTVCFSAFFASLSQNIYSPILPIIKESFHVST AMVNLSVSVFMIVTAIMQIILGAIIDFKGARIVLITGILATAAASIGCAVTTDFTLFL IFRMIQAAGSAALPLIAATTIGQLFTGNERGSAMGTYQMLLSVAPAIAPVLGGFIGGA AGYEGIFWILAAISIVLLVTNSITFPKDSPTESMQQAKGNVFAHYKSIFTNRTGNVIL TLSFVLFFIYFAVIVYLPILLTEHYHIDVGIAGLLYLPLALSTIAGTFLFKRIQAKIG LHTLFIGSNVIAACSIILFAVTHSVSLVLMALTLALFGISMGVIPPLYSTMITNEFEH NRGSAIGMFNFIRYTGMAAGPMVSAYLLTMMPSAMSFSLLGLGFAALSFCLLPPMFSP QKRTKQKKHHM*" /label="pchE CDS" gene 3256637..3257848 /gene="pchE" /locus_tag="BSU_35090" /old_locus_tag="BSU35090" /label="pchE gene" downshifts 3257846 /Source="Nicolas_upshifts" /id="D1815" /incds=0 /nref=33 /ntot=196 /MaxReadThrough="5.27186" /MaxDrop="4.73361" /score="54.0406126" /energy="-11.4" /TU="U2748" /idTUdmin="U2748" /TUdmin="-721" /isTUend="FALSE" /label="downshifts" CDS complement(3257876..3258235) /gene="yvlD" /locus_tag="BSU_35100" /old_locus_tag="BSU35100" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 26296725; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral phage holin-like membrane protein" /protein_id="NP_391390.1" /db_xref="EnsemblGenomes-Gn:BSU35100" /db_xref="EnsemblGenomes-Tr:CAB15515" /db_xref="GOA:O34648" /db_xref="InterPro:IPR007165" /db_xref="SubtiList:BG14119" /db_xref="UniProtKB/Swiss-Prot:O34648" /translation="MVKWAVSILVNALLLIVIDGYIDSIHISSIGAAIIASLILSILN VLIKPLLIIFTLPVTMVTLGLFLFVINAITLMMTASIMGDSFQIDGFGTAIWASVILS VFHLLIQKGILEPLRKK*" /label="yvlD CDS" gene complement(3257876..3258235) /gene="yvlD" /locus_tag="BSU_35100" /old_locus_tag="BSU35100" /label="yvlD gene" S_feature 3257891..3258607 /Source="Nicolas_S_feature" /locus_tag="new_3606777_3607493" /HighExp="LBGstat, S8, Gly, C30, G135, S7, C90, Sw, Fru, S6" /AntisenseName="yvlC" /AntisenseCor="0.178445666283919" /AntisenseRegPval="-2.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1339" downshifts complement(3257895) /Source="Nicolas_upshifts" /id="D1816" /incds=0 /nref=129 /ntot=265 /MaxReadThrough="4.63835" /MaxDrop="5.15146" /score="14.4434545" /energy="-9.6" /TU="U2749" /idTUdmin="U2751" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3258237..3258434) /gene="yvlC" /locus_tag="BSU_35110" /old_locus_tag="BSU35110" /function="16.3: Control" /function="16.12: Sense" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 23980836; Product type r : regulator" /codon_start=1 /transl_table=11 /product="membrane associated phage-like stress regulator,nisin resistance" /protein_id="NP_391391.1" /db_xref="EnsemblGenomes-Gn:BSU35110" /db_xref="EnsemblGenomes-Tr:CAB15516" /db_xref="GOA:O34719" /db_xref="InterPro:IPR007168" /db_xref="SubtiList:BG14118" /db_xref="UniProtKB/Swiss-Prot:O34719" /translation="MNKLYRSEKNKKIAGVIGGLAEYFNWDASLLRVITVILAIMTSV LPVLLIYIIWIFIVPSERDMK*" /label="yvlC CDS" gene complement(3258237..3258434) /gene="yvlC" /locus_tag="BSU_35110" /old_locus_tag="BSU35110" /label="yvlC gene" CDS complement(3258439..3259536) /gene="yvlB" /locus_tag="BSU_35120" /old_locus_tag="BSU35120" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 23980836" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function, stress-related" /protein_id="NP_391392.1" /db_xref="EnsemblGenomes-Gn:BSU35120" /db_xref="EnsemblGenomes-Tr:CAB15517" /db_xref="InterPro:IPR016599" /db_xref="InterPro:IPR025164" /db_xref="SubtiList:BG14117" /db_xref="UniProtKB/Swiss-Prot:O34628" /translation="MKQEKERILKLVEEGKLTAQEALTLIEKLDSDYKEKEEKITALS VHVHDEEEPFTTAKKESGKPSLGAKLFDWIDSAVKKVKEVDLDLNFGHAYDVQHIFQF KDTDFSSVELQIANGSVNIVPWEDDDIRAECQAKVYRADSQDAARHAFLQHIECEIKG NKFFIRTEKKTMKTNVTLYIPQKEYDKIRVKLFNGPVRGEHLHVKEFSAKTTNGVLSF SYLTAEKAIAETANGQIKLASHSCGTIEAETINGLIDLRGKSESIDVQSFNGNIAINV TESDCRSIYAKTTTGNVELAIPDDLAVKAELKSNLGTLSHELMDVEMLKEKNDTIQKE MMFTSNQAHDQNITVFSESLTGAIKLKYSQR*" /label="yvlB CDS" gene complement(3258439..3259536) /gene="yvlB" /locus_tag="BSU_35120" /old_locus_tag="BSU35120" /label="yvlB gene" CDS complement(3259561..3259887) /gene="yvlA" /locus_tag="BSU_35130" /old_locus_tag="BSU35130" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 23980836" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391393.1" /db_xref="EnsemblGenomes-Gn:BSU35130" /db_xref="EnsemblGenomes-Tr:CAB15518" /db_xref="GOA:O34322" /db_xref="SubtiList:BG14116" /db_xref="UniProtKB/Swiss-Prot:O34322" /translation="MNRNQAIIASLCYFSVFIAPIIVPIVAYFVVNEKETKRHAIRSL ISHIVPFVGWLFLFIALLGGAVAIDGDSLLPVFVIIGGAVIYFLVVIGIIIWNVIQGI KVLRAA*" /label="yvlA CDS" gene complement(3259561..3259887) /gene="yvlA" /locus_tag="BSU_35130" /old_locus_tag="BSU35130" /label="yvlA gene" promotor_-10 complement(3259940..3259955) /Source="Nicolas_upshift_promotors" /id="U2749" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1667 /SigmaFactorBS="ccaatttccgtaaatcggagcatgtctaaagaatgaattTGA AACCTGAagagattttaaACGTATAAATAAGTAAaacgtccctgatcttttgtcatgg a" /listShort="yvlA, yvlB, yvlC, yvlD, S1338" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3259955) /Source="Nicolas_upshifts" /id="U2749" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1667 /SigmaFactorBS="ccaatttccgtaaatcggagcatgtctaaagaatgaattTGA AACCTGAagagattttaaACGTATAAATAAGTAAaacgtccctgatcttttgtcatgg a" /listShort="yvlA, yvlB, yvlC, yvlD, S1338" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3259957..3260447) /Source="Nicolas_S_feature" /locus_tag="new_3608843_3609333_c" /HighExp="H2O2, G180, Paraq, G150, G135, dia15, Oxctl, Diami, Lbexp, LBGexp" /AntisenseName="yvkN" /AntisenseCor="0.37678416921083902" /AntisenseRegPval="-9.8000000000000007" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1340" promotor_-35 complement(3259967..3259976) /Source="Nicolas_upshift_promotors" /id="U2749" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1667 /SigmaFactorBS="ccaatttccgtaaatcggagcatgtctaaagaatgaattTGA AACCTGAagagattttaaACGTATAAATAAGTAAaacgtccctgatcttttgtcatgg a" /listShort="yvlA, yvlB, yvlC, yvlD, S1338" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3260035..3260038 /Source="Nicolas_upshift_promotors" /id="U2750" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.544455544455544" /psig="0.995004995004995" /xcortree=2993 /SigmaFactorBS="ttacggaaattggattttaaaaagttttagaaGTAGaatctt ccggctatACCGATTACAATATGTAAAAagcttacggcaaccaaggaggctggacaag c" /listShort="yvkN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3260053..3260072 /Source="Nicolas_upshift_promotors" /id="U2750" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.544455544455544" /psig="0.995004995004995" /xcortree=2993 /SigmaFactorBS="ttacggaaattggattttaaaaagttttagaaGTAGaatctt ccggctatACCGATTACAATATGTAAAAagcttacggcaaccaaggaggctggacaag c" /listShort="yvkN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3260063 /Source="Nicolas_upshifts" /id="U2750" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.544455544455544" /psig="0.995004995004995" /xcortree=2993 /SigmaFactorBS="ttacggaaattggattttaaaaagttttagaaGTAGaatctt ccggctatACCGATTACAATATGTAAAAagcttacggcaaccaaggaggctggacaag c" /listShort="yvkN" /GFF_Attribute="listLong" /label="upshifts" CDS 3260105..3260335 /gene="yvkN" /locus_tag="BSU_35140" /old_locus_tag="BSU35140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391394.1" /db_xref="EnsemblGenomes-Gn:BSU35140" /db_xref="EnsemblGenomes-Tr:CAB15519" /db_xref="SubtiList:BG14115" /db_xref="UniProtKB/Swiss-Prot:O34604" /translation="MEKDPSDYTVTQESVLKLIQEQKRMNREMITELEQIHGPFPISH DIQYIKVLLDSSNTHIVQDLMSVSKQLYKKTL*" /label="yvkN CDS" gene 3260105..3260335 /gene="yvkN" /locus_tag="BSU_35140" /old_locus_tag="BSU35140" /label="yvkN gene" promotor_-10 complement(3260438..3260457) /Source="Nicolas_upshift_promotors" /id="U2751" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.845154845154845" /psig="0.993006993006993" /xcortree=1844 /SigmaFactorBS="agttacagcttgccgacagagtccattaactGGATGtgccgg caggcttttTTTGTTACAATCATTTTGTGacagccagggaatcacttgttttttcaaa a" /listShort="S1340, yvlA, yvlB, yvlC, yvlD" /listLong="S1338" /label="promotor_-10" upshifts complement(3260448) /Source="Nicolas_upshifts" /id="U2751" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.845154845154845" /psig="0.993006993006993" /xcortree=1844 /SigmaFactorBS="agttacagcttgccgacagagtccattaactGGATGtgccgg caggcttttTTTGTTACAATCATTTTGTGacagccagggaatcacttgttttttcaaa a" /listShort="S1340, yvlA, yvlB, yvlC, yvlD" /listLong="S1338" /label="upshifts" promotor_-35 complement(3260473..3260477) /Source="Nicolas_upshift_promotors" /id="U2751" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.845154845154845" /psig="0.993006993006993" /xcortree=1844 /SigmaFactorBS="agttacagcttgccgacagagtccattaactGGATGtgccgg caggcttttTTTGTTACAATCATTTTGTGacagccagggaatcacttgttttttcaaa a" /listShort="S1340, yvlA, yvlB, yvlC, yvlD" /listLong="S1338" /label="promotor_-35" CDS complement(3260534..3261016) /gene="yvzB" /locus_tag="BSU_35150" /old_locus_tag="BSU35150" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16936039; Product type s: structure" /pseudo /codon_start=1 /transl_table=11 /product="putative flagellin" /db_xref="EnsemblGenomes-Gn:BSU35150" /db_xref="EnsemblGenomes-Tr:CAB15520" /db_xref="GOA:O34366" /db_xref="InterPro:IPR001029" /db_xref="PSEUDO:CAB15520.1" /db_xref="SubtiList:BG14158" /db_xref="UniProtKB/Swiss-Prot:O34366" /translation="MDALIEEVDGISNRTEFNGKKLLDGTETDGFTFQIGANAGQQLT VNIDSMSSTALGVNALNVTDFANTPFDTQLESIDTAINNVSNQRAKLGAVQNRLEHTI NNLGASSENLTAAESRIRDVDMAKEMSEFTKNNIPSQASQAMLAQANQQPQNVLQLLR *" /label="yvzB CDS" gene complement(3260534..3261016) /gene="yvzB" /locus_tag="BSU_35150" /old_locus_tag="BSU35150" /pseudo /label="yvzB gene" downshifts 3260542 /Source="Nicolas_upshifts" /id="D1817" /incds=0 /nref=13 /ntot=113 /MaxReadThrough="0.9814" /MaxDrop="4.76969" /score="2.6592903" /energy="-5.7" /TU="NA" /idTUdmin="U2750" /TUdmin=17 /isTUend="TRUE" /label="downshifts" downshifts complement(3260557) /Source="Nicolas_upshifts" /id="D1818" /incds=0 /nref=118 /ntot=206 /MaxReadThrough="2.62918" /MaxDrop="8.97968" /score="25.6132739" /energy="-19.8" /TU="NA" /idTUdmin="U2752" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts complement(3260689) /Source="Nicolas_upshifts" /id="U2752" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96003996003996" /psig="0.011988011988012" /xcortree=15 /SigmaFactorBS="aaacttggtgcggtacaaaaccgtctagagcacacaatcaac aaccttgGTGCttcttctgaaaacctgacagctgctgagtcccgtatccgtgacgttg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(3260697..3260700) /Source="Nicolas_upshift_promotors" /id="U2752" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.96003996003996" /psig="0.011988011988012" /xcortree=15 /SigmaFactorBS="aaacttggtgcggtacaaaaccgtctagagcacacaatcaac aaccttgGTGCttcttctgaaaacctgacagctgctgagtcccgtatccgtgacgttg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(3260777..3260781) /Source="Nicolas_upshift_promotors" /id="U2753" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.831168831168831" /psig="0.154845154845155" /xcortree=16 /SigmaFactorBS="taatgtaacagattttgctaatactccttttgatacaCAACt tgaaagtattgataCTGCAatcaacaatgtctcaaaccaacgtgctaaacttggtgcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3260777) /Source="Nicolas_upshifts" /id="U2753" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.831168831168831" /psig="0.154845154845155" /xcortree=16 /SigmaFactorBS="taatgtaacagattttgctaatactccttttgatacaCAACt tgaaagtattgataCTGCAatcaacaatgtctcaaaccaacgtgctaaacttggtgcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3260797..3260800) /Source="Nicolas_upshift_promotors" /id="U2753" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.831168831168831" /psig="0.154845154845155" /xcortree=16 /SigmaFactorBS="taatgtaacagattttgctaatactccttttgatacaCAACt tgaaagtattgataCTGCAatcaacaatgtctcaaaccaacgtgctaaacttggtgcg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3261017..3261150) /Source="Nicolas_S_feature" /locus_tag="new_3609903_3610036_c" /HighExp="H2O2, Sw, M40t45, M40t90, Diami, Salt, dia15, BC, G135, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="1, 1" /TUlongSig="SigA" /TUlongPSig=1 /label="S1341" CDS complement(3261178..3264051) /gene="uvrA" /locus_tag="BSU_35160" /old_locus_tag="BSU35160" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11751826, 16267290, 16426634, 25713353, 27399782" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11751826, 16267290, 16426634, 25713353, 27399782; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="excinuclease ABC (subunit A)" /protein_id="NP_391396.1" /db_xref="EnsemblGenomes-Gn:BSU35160" /db_xref="EnsemblGenomes-Tr:CAB15533" /db_xref="GOA:O34863" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004602" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12697" /db_xref="UniProtKB/Swiss-Prot:O34863" /translation="MAMDRIEVKGARAHNLKNIDVTIPRDQLVVVTGLSGSGKSSLAF DTIYAEGQRRYVESLSAYARQFLGQMDKPDVDAIEGLSPAISIDQKTTSRNPRSTVGT VTEIYDYLRLLYARVGKPHCPEHGIEITSQTIEQMVDRILEYPERTKLQVLAPIVSGR KGAHVKVLEQIRKQGYVRVRIDGEMAELSDDIELEKNKKHSIEVVIDRIVVKEGVAAR LSDSLETALRLGEGRVMIDVIGEEELMFSEHHACPHCGFSIGELEPRLFSFNSPFGAC PTCDGLGMKLEVDADLVIPNQDLSLKENAVAPWTPISSQYYPQLLEAVCTHYGIDMDV PVKDLPKHQLDKVLYGSGDDLIYFRYENDFGQIREGEIQFEGVLRNIERRYKETGSDF IREQMEQYMSQKSCPTCKGYRLKKEALAVLIDGRHIGKITELSVADALAFFKDLTLSE KDMQIANLILREIVERLSFLDKVGLDYLTLSRAAGTLSGGEAQRIRLATQIGSRLSGV LYILDEPSIGLHQRDNDRLISALKNMRDLGNTLIVVEHDEDTMMAADYLIDIGPGAGI HGGQVISAGTPEEVMEDPNSLTGSYLSGKKFIPLPPERRKPDGRYIEIKGASENNLKK VNAKFPLGTFTAVTGVSGSGKSTLVNEILHKALAQKLHKAKAKPGSHKEIKGLDHLDK VIDIDQAPIGRTPRSNPATYTGVFDDIRDVFAQTNEAKVRGYKKGRFSFNVKGGRCEA CRGDGIIKIEMHFLPDVYVPCEVCHGKRYNRETLEVTYKGKSISDVLDMTVEDALSFF ENIPKIKRKLQTLYDVGLGYITLGQPATTLSGGEAQRVKLASELHKRSTGRTLYILDE PTTGLHVDDIARLLVVLQRLVDNGDTVLVIEHNLDIIKTADYIVDLGPEGGAGGGTIV ASGTPEEITEVEESYTGRYLKPVIERDKTRMKSLLKAKETATS*" /label="uvrA CDS" gene complement(3261178..3264051) /gene="uvrA" /locus_tag="BSU_35160" /old_locus_tag="BSU35160" /label="uvrA gene" downshifts complement(3261195) /Source="Nicolas_upshifts" /id="D1819" /incds=0 /nref=240 /ntot=268 /MaxReadThrough="4.46283" /MaxDrop="5.3695" /score="12.0157254" /energy="-18.6" /TU="U2754,U2756" /idTUdmin="U2755" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3264059..3266044) /gene="uvrB" /locus_tag="BSU_35170" /old_locus_tag="BSU35170" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:11751826, 16267290, 16426634, 25713353, 27399782" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11751826, 16267290, 16426634, 25713353, 27399782; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="excinuclease ABC (subunit B)" /protein_id="NP_391397.1" /db_xref="EnsemblGenomes-Gn:BSU35170" /db_xref="EnsemblGenomes-Tr:CAB15534" /db_xref="GOA:P37954" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR001943" /db_xref="InterPro:IPR004807" /db_xref="InterPro:IPR006935" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR024759" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036876" /db_xref="PDB:2D7D" /db_xref="PDB:2NMV" /db_xref="PDB:3V4R" /db_xref="SubtiList:BG10502" /db_xref="UniProtKB/Swiss-Prot:P37954" /translation="MKDRFELVSKYQPQGDQPKAIEKLVKGIQEGKKHQTLLGATGTG KTFTVSNLIKEVNKPTLVIAHNKTLAGQLYSEFKEFFPNNAVEYFVSYYDYYQPEAYV PQTDTFIEKDASINDEIDKLRHSATSALFERRDVIIIASVSCIYGLGSPEEYREMVVS LRTEMEIERNELLRKLVDIQYARNDIDFQRGTFRVRGDVVEIFPASRDEHCVRVEFFG DEIERIREVDALTGEILGDRDHVAIFPASHFVTRAEKMEKAIQNIEKELEEQLKVMHE NGKLLEAQRLEQRTRYDLEMMREMGFCSGIENYSRHLTLRPPGSTPYTLLDYFPDDFM IVVDESHVTIPQVRGMFNGDQARKQVLVDHGFRLPSALDNRPLRFEEFEKHMHNIVYV SATPGPYEIEHTDEMVEQIIRPTGLLDPLIDVRPIEGQIDDLIGEIQARIERNERVLV TTLTKKMSEDLTDYLKEIGIKVNYLHSEIKTLERIEIIRDLRLGKYDVLVGINLLREG LDIPEVSLVAILDADKEGFLRSERSLIQTIGRAARNAEGRVIMYADKITKSMEIAINE TKRRREQQERFNEEHGITPKTINKEIRDVIRATVAAEDKAEYKTKAAPKLSKMTKKER QKVVEQMEHEMKEAAKALDFERAAELRDLLLELKAEG*" /label="uvrB CDS" gene complement(3264059..3266044) /gene="uvrB" /locus_tag="BSU_35170" /old_locus_tag="BSU35170" /label="uvrB gene" promotor_-10 complement(3266078..3266097) /Source="Nicolas_upshift_promotors" /id="U2754" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=2093 /SigmaFactorBS="aaataaaaaaccaccgaactttagttcgtattttTAGTGATT ttgctttccatTGTGTTACTATATCTATAGGaagatttcgttaaagaaacggaggctt a" /listShort="uvrB, uvrA, S1341, yvzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3266090) /Source="Nicolas_upshifts" /id="U2754" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=2093 /SigmaFactorBS="aaataaaaaaccaccgaactttagttcgtattttTAGTGATT ttgctttccatTGTGTTACTATATCTATAGGaagatttcgttaaagaaacggaggctt a" /listShort="uvrB, uvrA, S1341, yvzB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3266092..3266177) /Source="Nicolas_S_feature" /locus_tag="new_3614978_3615063_c" /HighExp="Gly, Sw, B60, BT, LoTm, Salt, Etha, M9-stat, B36, S0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1342" promotor_-35 complement(3266109..3266116) /Source="Nicolas_upshift_promotors" /id="U2754" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.756243756243756" /psig=1 /xcortree=2093 /SigmaFactorBS="aaataaaaaaccaccgaactttagttcgtattttTAGTGATT ttgctttccatTGTGTTACTATATCTATAGGaagatttcgttaaagaaacggaggctt a" /listShort="uvrB, uvrA, S1341, yvzB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3266222) /Source="Nicolas_upshifts" /id="D1820" /incds=0 /nref=4 /ntot=60 /MaxReadThrough="5.68784" /MaxDrop="3.17938" /score="11.285993" /energy="-12" /TU="U2755,U2756" /idTUdmin="U2755" /TUdmin="-5027" /isTUend="FALSE" /label="downshifts" CDS complement(3266230..3266460) /gene="csbA" /locus_tag="BSU_35180" /old_locus_tag="BSU35180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 1592822, 1744042; Product type m:membrane component" /codon_start=1 /transl_table=11 /product="conserved membrane protein of unknown function" /protein_id="NP_391398.1" /db_xref="EnsemblGenomes-Gn:BSU35180" /db_xref="EnsemblGenomes-Tr:CAB15535" /db_xref="GOA:P37953" /db_xref="InterPro:IPR019242" /db_xref="SubtiList:BG10501" /db_xref="UniProtKB/Swiss-Prot:P37953" /translation="MITKAVFALFFPFMLVVLFTRVTFNHYVAIALTAALLFASYLKG YTETYFIVGLDVVSLVAGGLYMAKKAAEKKEE*" /label="csbA CDS" gene complement(3266230..3266460) /gene="csbA" /locus_tag="BSU_35180" /old_locus_tag="BSU35180" /label="csbA gene" promotor_-10 complement(3266487..3266506) /Source="Nicolas_upshift_promotors" /id="U2755" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.61038961038961" /psig=1 /xcortree=598 /SigmaFactorBS="ggtatggtgtaagtagagggagcgaatgcaCGATTGTCcgat tcttcatttTTTACTATAATCAGATCAGAtgaagaatccctgaggagggtttttgttg a" /listShort="csbA, S1342, uvrB, uvrA" /listLong="S1341, yvzB" /label="promotor_-10" upshifts complement(3266497) /Source="Nicolas_upshifts" /id="U2755" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.61038961038961" /psig=1 /xcortree=598 /SigmaFactorBS="ggtatggtgtaagtagagggagcgaatgcaCGATTGTCcgat tcttcatttTTTACTATAATCAGATCAGAtgaagaatccctgaggagggtttttgttg a" /listShort="csbA, S1342, uvrB, uvrA" /listLong="S1341, yvzB" /label="upshifts" S_feature complement(3266499..3266563) /Source="Nicolas_S_feature" /locus_tag="new_3615385_3615449_c" /HighExp="Gly, M9-stat, B60, Sw, Etha, LoTm, BT, B36, T1.30H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1343" promotor_-35 complement(3266520..3266527) /Source="Nicolas_upshift_promotors" /id="U2755" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.61038961038961" /psig=1 /xcortree=598 /SigmaFactorBS="ggtatggtgtaagtagagggagcgaatgcaCGATTGTCcgat tcttcatttTTTACTATAATCAGATCAGAtgaagaatccctgaggagggtttttgttg a" /listShort="csbA, S1342, uvrB, uvrA" /listLong="S1341, yvzB" /label="promotor_-35" promotor_-10 complement(3266540..3266558) /Source="Nicolas_upshift_promotors" /id="U2756" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=196 /SigmaFactorBS="accatggaataagttttgaccggcaccaaaatgcaaatatgg TGATTGAttttggctgaaaagGGGTATGGTGTAAGTAGAGggagcgaatgcacgattg t" /listShort="S1343, csbA, S1342, uvrB, uvrA, S1341, yvzB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3266561) /Source="Nicolas_upshifts" /id="U2756" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=196 /SigmaFactorBS="accatggaataagttttgaccggcaccaaaatgcaaatatgg TGATTGAttttggctgaaaagGGGTATGGTGTAAGTAGAGggagcgaatgcacgattg t" /listShort="S1343, csbA, S1342, uvrB, uvrA, S1341, yvzB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3266573..3266579) /Source="Nicolas_upshift_promotors" /id="U2756" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=196 /SigmaFactorBS="accatggaataagttttgaccggcaccaaaatgcaaatatgg TGATTGAttttggctgaaaagGGGTATGGTGTAAGTAGAGggagcgaatgcacgattg t" /listShort="S1343, csbA, S1342, uvrB, uvrA, S1341, yvzB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3266629) /Source="Nicolas_upshifts" /id="D1821" /incds=0 /nref=1 /ntot=9 /MaxReadThrough="0.9693" /MaxDrop="4.37808" /score="-1.92287727" /energy="-4.2" /TU="NA" /idTUdmin="U2761" /TUdmin=4752 /isTUend="FALSE" /label="downshifts" promotor_no_box complement(3266655..3266755) /Source="Nicolas_upshift_promotors" /id="U2757" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.236763236763237" /psig="0.378621378621379" /xcortree=1470 /SigmaFactorBS="aatagttaagttggttatattatcctgaaaaatgcggccgta ctggtactgtatgcctattttcttttattctcggaatctggcggcggacttgatgatg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(3266695) /Source="Nicolas_upshifts" /id="U2757" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.236763236763237" /psig="0.378621378621379" /xcortree=1470 /SigmaFactorBS="aatagttaagttggttatattatcctgaaaaatgcggccgta ctggtactgtatgcctattttcttttattctcggaatctggcggcggacttgatgatg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3266777..3266784 /Source="Nicolas_upshift_promotors" /id="U2758" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig="0.999000999001" /xcortree=566 /SigmaFactorBS="tcattttatttaggactttctgCGTTTGACagcattttcctg aAAACCTACAATTAAATGATAgtgtttactatcattttttaaacacaggctccgcaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3266798..3266817 /Source="Nicolas_upshift_promotors" /id="U2758" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig="0.999000999001" /xcortree=566 /SigmaFactorBS="tcattttatttaggactttctgCGTTTGACagcattttcctg aAAACCTACAATTAAATGATAgtgtttactatcattttttaaacacaggctccgcaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3266815 /Source="Nicolas_upshifts" /id="U2758" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.608391608391608" /psig="0.999000999001" /xcortree=566 /SigmaFactorBS="tcattttatttaggactttctgCGTTTGACagcattttcctg aAAACCTACAATTAAATGATAgtgtttactatcattttttaaacacaggctccgcaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 3266907..3269402 /gene="yvkC" /locus_tag="BSU_35190" /old_locus_tag="BSU35190" /EC_number="2.7.-.-" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 25012659; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphotransferase" /protein_id="NP_391399.1" /db_xref="EnsemblGenomes-Gn:BSU35190" /db_xref="EnsemblGenomes-Tr:CAB15536" /db_xref="GOA:O34796" /db_xref="InterPro:IPR002192" /db_xref="InterPro:IPR008279" /db_xref="InterPro:IPR013815" /db_xref="SubtiList:BG14114" /db_xref="UniProtKB/Swiss-Prot:O34796" /translation="MYSVLFRQAEESSQLAGAKGMNLIKLTKHGLPVPDGFIIQTNAL ARFMEDNQLQETSENVEGGIISGTFSDELKDELTSSFYKLRESYRSVAVRSSSASEDL EGASFAGQYETYLNIKTEEEFLAKVKECWASFFSGRVSSYKKKMNNQIAEPLMGIVVQ GLIDSEMSGVIFSRNPVTHDDRELLISASYGLGEAVVSGNVTPDTFIVNKSSFEIQKE IGAKEIYMESAAEGIAEKETSEDMRSRFCLTDEQVIELAEITKKTEDLYGYPVDIEFG IADHQIYLLQARPITTIDQDKKAAEEKRSFMITDTDMNDFWLNMESNIEGPVSPLFSS FIVPALEYGLKKSMQKFPIGVVVDEVKLYRGHIYSKNQGGQQPPSEDCGKELFPILSE HMYDIINHTYLPFYRTLDQLAQTEHTAESALEAFQKLKAFYLTAYEEHFNIVFPQILL TNKLQAMYQDIQGESENAHFYEMLTGKMNKSLETDRCLWLFSVEVQENPNLLAIFENN KPEQLQEKLEQTDEGRHFLKNVHEFLQEYGWRSVKSHDLIEQIWVENPYFALANIQNY VRNGYHFDNEFQKTKEKREKLYNEFLESIEDPGLRTEFDRYYQWTLNSANIKDDHHFY IDAMLDAKARIFLLKIGELLAENGVIQDREDLWFLYDDEVEQALLHPVSLQEKAEKRR QIFHEYELAQAPAYLGTPTKEQLKAAEEIVGAVIEDEKNTENHIFGIAASSGIATGPV KIIRDANEFSQFAPGDVLVCKMTTPLWTSLFQDAKAIITDTGGILSHAAIIAREYGIP AVLGTRTATERLRDGDIITVDGSSGKITVVSRS*" /label="yvkC CDS" gene 3266907..3269402 /gene="yvkC" /locus_tag="BSU_35190" /old_locus_tag="BSU35190" /label="yvkC gene" misc_feature 3269417..3269421 /Source="Nicolas_upshift_promotors" /id="U2759" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.358641358641359" /psig="0.448551448551449" /xcortree=2520 /SigmaFactorBS="caaaatcacagttgtcagccggtcctgatgcgtccccctctt TCTTAtacaagcggggcgggtgtatacttgtcctgccagtatattcgtgaggtgaaac g" /listShort="yvkB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3269435 /Source="Nicolas_upshifts" /id="U2759" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.358641358641359" /psig="0.448551448551449" /xcortree=2520 /SigmaFactorBS="caaaatcacagttgtcagccggtcctgatgcgtccccctctt TCTTAtacaagcggggcgggtgtatacttgtcctgccagtatattcgtgaggtgaaac g" /listShort="yvkB" /GFF_Attribute="listLong" /label="upshifts" CDS 3269478..3270047 /gene="yvkB" /locus_tag="BSU_35200" /old_locus_tag="BSU35200" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (TetR/AcrR family)" /protein_id="NP_391400.1" /db_xref="EnsemblGenomes-Gn:BSU35200" /db_xref="EnsemblGenomes-Tr:CAB15537" /db_xref="GOA:O34643" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="SubtiList:BG14113" /db_xref="UniProtKB/Swiss-Prot:O34643" /translation="MRPTNKRILDAAMQLLVKKGYRATTTKEIAEKANVSEATIFRNF KNKQGLVEALLSQHSSNRGSILEQTEGDLYKDLLHIGTCLLEELEHRKDIIKISFREP AMFQDVINHVTEYPQSMKQLLVDYLKTMGEKGVIQTGNEAEHADVFMSIIFGYFIHRL HLGDRVISMPQEKMLEHSTALFVKGISAD*" /label="yvkB CDS" gene 3269478..3270047 /gene="yvkB" /locus_tag="BSU_35200" /old_locus_tag="BSU35200" /label="yvkB gene" CDS 3270078..3271412 /gene="yvkA" /locus_tag="BSU_35210" /old_locus_tag="BSU35210" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_391401.1" /db_xref="EnsemblGenomes-Gn:BSU35210" /db_xref="EnsemblGenomes-Tr:CAB15538" /db_xref="GOA:O34502" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG14112" /db_xref="UniProtKB/Swiss-Prot:O34502" /translation="MSSRKEWALIVSLLLGAILVPINSTMIAVALSSISHTYNESIAS ITWVVTVYLIVMAVTQPIAGKLGDMYGNKTMYLWGVGLFLIASLGCALSPSLLLLIVF RALQAVGGALLTPNSIAIIRHVVSEKRLPKVFGFFGLGAGLGAALGPFIGSILIDSFS WHSIFWVNIPFLAIALFTALTMFPQYKENKSDAPLDIIGSLLLAGSIVSIILLTKNEA PWGYTVYSVLILLFVPLFFRREKRTQHPIIDFALFKSSTFTNANLSVLLSNLMMYAVL LIMPLFMTNQFGLNTSNSGMALSVFSIFMSASNWVGAQLHHKWGAKKIIFLSFAMMAG ANLLFLLLSSSHSVLFLMLSLILGGLASGVGLTSMQVSSLATVDPGMSGVASGIFSTF RYFGSIISSALIGLISGYHTLFMILFAVSIIGVFVSLGIKSDETARIEKNSA*" /label="yvkA CDS" gene 3270078..3271412 /gene="yvkA" /locus_tag="BSU_35210" /old_locus_tag="BSU35210" /label="yvkA gene" downshifts 3271393 /Source="Nicolas_upshifts" /id="D1822" /incds=0 /nref=4 /ntot=118 /MaxReadThrough="0.94661" /MaxDrop="3.57731" /score="21.0606505" /energy="-28.8" /TU="NA" /idTUdmin="U2759" /TUdmin=1276 /isTUend="FALSE" /label="downshifts" CDS complement(3271460..3272653) /gene="minJ" /locus_tag="BSU_35220" /old_locus_tag="BSU35220" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15849754, 16030230, 16850406, 18976281, 19019154, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16030230, 16850406, 18976281, 19019154, 26735940; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="topological determinant of cell division" /protein_id="NP_391402.1" /db_xref="EnsemblGenomes-Gn:BSU35220" /db_xref="EnsemblGenomes-Tr:CAB15539" /db_xref="GOA:O34375" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR036034" /db_xref="SubtiList:BG14111" /db_xref="UniProtKB/Swiss-Prot:O34375" /translation="MSVQWGIELLKSAGLFFLHPLFWFFIIITLAFGYVRIKRERKTF HTRIADIYDDLKFTYTKGLIPGLLLSVILGGLGISIPLGLLAIIAVITAAAAFTLRAN WMSAAYIVSVSMLIGFGLQIYQAEPFLERFPQGFAVVWPAVAVFLGLLIITEGAVAYR SAHVRTSPALVVSSRGLPIGQQLANRVWLLPLFLLVPGNGLESHLSWWPVFTVPGGSF HFLWIPYFVGFGQRVQGSLPETSIRITAKRVCILGLAVAVLGAASLLWTPLAGAAVCT ALLGRIFLSIKQRVNDNAAPFYFSKRDQGLMVLGIIPNTPAEDLELKIGEIITKVNGI PVKNVSDFYEALQHNRAYVKLEIIGLNGEIRFDQRASYEGEHHELGILFVKDDREDEA VASGS*" /label="minJ CDS" gene complement(3271460..3272653) /gene="minJ" /locus_tag="BSU_35220" /old_locus_tag="BSU35220" /label="minJ gene" downshifts complement(3271469) /Source="Nicolas_upshifts" /id="D1823" /incds=0 /nref=3 /ntot=85 /MaxReadThrough="3.18641" /MaxDrop="3.13207" /score="21.4231982" /energy="-25.6" /TU="U2761" /idTUdmin="U2760" /TUdmin=66 /isTUend="FALSE" /label="downshifts" downshifts complement(3271534) /Source="Nicolas_upshifts" /id="D1824" /incds=1 /nref=94 /ntot=239 /MaxReadThrough="4.11808" /MaxDrop="4.31508" /score="21.4231982" /energy="-25.6" /TU="U2761" /idTUdmin="U2760" /TUdmin=1 /isTUend="TRUE" /label="downshifts" S_feature complement(3272654..3272731) /Source="Nicolas_S_feature" /locus_tag="new_3621540_3621617_c" /HighExp="LBGstat, Lbstat, M0t90, Cold, M/G, GM 10, GM 25, GM 15, GM 60, GM 45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD, SigGF" /TUshortPSig="0.945, 0.998, 0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S1344" downshifts complement(3272657) /Source="Nicolas_upshifts" /id="D1825" /incds=0 /nref=1 /ntot=13 /MaxReadThrough="6.36185" /MaxDrop="3.35962" /score="-9.46264764" /energy="-7.1" /TU="U2760,U2761,U2762" /idTUdmin="U2762" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" CDS complement(3272732..3273070) /gene="swrAAc" /locus_tag="BSU_35230" /old_locus_tag="BSU35230" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15066026, 16030230" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15066026, 16030230; Product type cp: cell process" /pseudo /codon_start=1 /transl_table=11 /product="swarming motility protein fragment; C-terminal part of swrAA" /db_xref="GOA:O32266" /db_xref="InterPro:IPR035388" /db_xref="PSEUDO:CAB15540.1" /db_xref="SubtiList:BG14160" /db_xref="UniProtKB/Swiss-Prot:O32266" /translation="MCVKKKYYELVEQLKDRTQDVTFSATKALSLLMLFSRYLVNYTN VESVNDINEECAKHYFNYLMKNHKRLGINLTDIKRSMHLISGLLDVDVNHYLKDFSLS NVTLWMTQER*" /label="swrAAc CDS" gene complement(3272732..3273070) /gene="swrAAc" /locus_tag="BSU_35230" /old_locus_tag="BSU35230" /pseudo /label="swrAAc gene" CDS complement(3273045..3273161) /gene="swrAAn" /locus_tag="BSU_35239" /old_locus_tag="BSU35239" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1a: Function from experimental evidences in the studied strain; Product type cp: cell process" /pseudo /codon_start=1 /transl_table=11 /product="swarming motility protein; N-terminal part of swrAA" /db_xref="PSEUDO:CAX52697.1" /translation="MLVSTPVLLLILARAYLYKENGGSQLKRASIVREKKIL*" /label="swrAAn CDS" gene complement(3273045..3273161) /gene="swrAAn" /locus_tag="BSU_35239" /old_locus_tag="BSU35239" /pseudo /label="swrAAn gene" S_feature complement(3273162..3273251) /Source="Nicolas_S_feature" /locus_tag="new_3622048_3622137_c" /HighExp="LBGstat, M0t90, Cold, Lbstat, GM 25, Gly, nit, GM 15, GM 10, M/G" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD, SigGF" /TUshortPSig="0.945, 0.998, 0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S1345" promotor_-10 complement(3273233..3273251) /Source="Nicolas_upshift_promotors" /id="U2760" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.494505494505495" /psig="0.945054945054945" /xcortree=2762 /SigmaFactorBS="ttctaacgagttaatatgcatttaaaatgaaacttttgcaaG TTGCCtagtctttgtttaCTTCATACAATATAAGAAGgttctaaaaagaacagtaatc a" /listShort="S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3273251) /Source="Nicolas_upshifts" /id="U2760" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.494505494505495" /psig="0.945054945054945" /xcortree=2762 /SigmaFactorBS="ttctaacgagttaatatgcatttaaaatgaaacttttgcaaG TTGCCtagtctttgtttaCTTCATACAATATAAGAAGgttctaaaaagaacagtaatc a" /listShort="S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3273253..3273333) /Source="Nicolas_S_feature" /locus_tag="new_3622139_3622219_c" /HighExp="LBGstat, Lbstat, Cold, M0t90, GM 25, nit, Gly, M/G, MG 150, GM 150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigGF" /TUshortPSig="0.998, 0.992" /TUlongSig="NA" /TUlongPSig="NA" /label="S1346" promotor_-35 complement(3273265..3273270) /Source="Nicolas_upshift_promotors" /id="U2760" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.494505494505495" /psig="0.945054945054945" /xcortree=2762 /SigmaFactorBS="ttctaacgagttaatatgcatttaaaatgaaacttttgcaaG TTGCCtagtctttgtttaCTTCATACAATATAAGAAGgttctaaaaagaacagtaatc a" /listShort="S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3273319..3273337) /Source="Nicolas_upshift_promotors" /id="U2761" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=2797 /SigmaFactorBS="ttgacaagaaattaaaaaaattttcacaaataaacATTTATA AaggactgttattaCCCGATATCAATATATGAGagagactttctaacgagttaatatg c" /listShort="S1346, S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3273333) /Source="Nicolas_upshifts" /id="U2761" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=2797 /SigmaFactorBS="ttgacaagaaattaaaaaaattttcacaaataaacATTTATA AaggactgttattaCCCGATATCAATATATGAGagagactttctaacgagttaatatg c" /listShort="S1346, S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3273351..3273358) /Source="Nicolas_upshift_promotors" /id="U2761" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=2797 /SigmaFactorBS="ttgacaagaaattaaaaaaattttcacaaataaacATTTATA AaggactgttattaCCCGATATCAATATATGAGagagactttctaacgagttaatatg c" /listShort="S1346, S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3273470..3274912) /gene="ctpB" /locus_tag="BSU_35240" /old_locus_tag="BSU35240" /function="16.3: Control" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:14526016, 17557826, 27342562" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14526016, 17557826, 27342562; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="PDZ-containing carboxyl-terminal protease processing protease [Zn(II)]" /protein_id="NP_391404.1" /db_xref="EnsemblGenomes-Gn:BSU35240" /db_xref="EnsemblGenomes-Tr:CAB15541" /db_xref="GOA:O35002" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR002477" /db_xref="InterPro:IPR004447" /db_xref="InterPro:IPR005151" /db_xref="InterPro:IPR029045" /db_xref="InterPro:IPR036034" /db_xref="InterPro:IPR036365" /db_xref="InterPro:IPR036366" /db_xref="PDB:4C2C" /db_xref="PDB:4C2D" /db_xref="PDB:4C2E" /db_xref="PDB:4C2F" /db_xref="PDB:4C2G" /db_xref="PDB:4C2H" /db_xref="SubtiList:BG14110" /db_xref="UniProtKB/Swiss-Prot:O35002" /translation="MNQKIMAVIAAGSMLFGGAGVYAGINLLEMDKPQTAAVPATAQA DSERDKAMDKIEKAYELISNEYVEKVDREKLLEGAIQGMLSTLNDPYSVYMDKQTAKQ FSDSLDSSFEGIGAEVGMEDGKIIIVSPFKKSPAEKAGLKPNDEIISINGESMAGKDL NHAVLKIRGKKGSSVSMKIQRPGTKKQLSFRIKRAEIPLETVFASEKKVQGHSVGYIA ISTFSEHTAEDFAKALRELEKKEIEGLVIDVRGNPGGYLQSVEEILKHFVTKDQPYIQ IAERNGDKKRYFSTLTHKKAYPVNVITDKGSASASEILAGALKEAGHYDVVGDTSFGK GTVQQAVPMGDGSNIKLTLYKWLTPNGNWIHKKGIEPTIAIKQPDYFSAGPLQLKEPL KVDMNNEDVKHAQVLLKGLSFDPGREDGYFSKDMKKAVMAFQDQNKLNKTGVIDTRTA ETLNQQIEKKKSDEKNDLQLQTALKSLFVN*" /label="ctpB CDS" gene complement(3273470..3274912) /gene="ctpB" /locus_tag="BSU_35240" /old_locus_tag="BSU35240" /label="ctpB gene" downshifts complement(3273559) /Source="Nicolas_upshifts" /id="D1826" /incds=1 /nref=1 /ntot=30 /MaxReadThrough="3.56833" /MaxDrop="3.1636" /score="0.562448109" /energy="-11.6" /TU="U2762" /idTUdmin="U2762" /TUdmin="-1122" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3274958..3274969) /Source="Nicolas_upshift_promotors" /id="U2762" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1138 /SigmaFactorBS="cgggacggcttttcatttgccttctttttcttctatgatTAC ATGAaatctccatcctttACATATACTATCtctaggttttggtaaagacagtctggca t" /listShort="ctpB, S1346, S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3274969) /Source="Nicolas_upshifts" /id="U2762" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1138 /SigmaFactorBS="cgggacggcttttcatttgccttctttttcttctatgatTAC ATGAaatctccatcctttACATATACTATCtctaggttttggtaaagacagtctggca t" /listShort="ctpB, S1346, S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3274984..3274990) /Source="Nicolas_upshift_promotors" /id="U2762" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=1138 /SigmaFactorBS="cgggacggcttttcatttgccttctttttcttctatgatTAC ATGAaatctccatcctttACATATACTATCtctaggttttggtaaagacagtctggca t" /listShort="ctpB, S1346, S1345, swrAA, swrAA, S1344, minJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3275052..3275942) /gene="ftsX" /locus_tag="BSU_35250" /old_locus_tag="BSU35250" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16352817, 17071757, 17307852, 18573177, 23855774, 23869552" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16352817, 17071757, 17307852, 18573177, 23855774, 23869552; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="cell-division ABC transporter" /protein_id="NP_391405.1" /db_xref="EnsemblGenomes-Gn:BSU35250" /db_xref="EnsemblGenomes-Tr:CAB15542" /db_xref="GOA:O34876" /db_xref="InterPro:IPR003838" /db_xref="InterPro:IPR004513" /db_xref="SubtiList:BG12591" /db_xref="UniProtKB/Swiss-Prot:O34876" /translation="MIKILGRHLRESFKSLGRNTWMTFASISAVTVTLILVGVFLVIM LNLNNMATNAEKQVEIKVLIDLTADQKAQDKLQNDIKELKGIQSVTFSSKEKELDQLV DSFGDSGKSLTMKDQENPLNDAFVVKTTDPHDTPNVAKKIEKMDHVYKVTYGKEEVSR LFKVVGVSRNIGIALIIGLVFTAMFLISNTIKITIFARRKEIEIMKLVGATNWFIRWP FFLEGLLLGVFGSVIPIALVLSTYQYVIGWVVPKVQGSFVSLLPYNPFVFQVSLVLIA IGAVIGVWGSLTSIRKFLRV*" /label="ftsX CDS" gene complement(3275052..3275942) /gene="ftsX" /locus_tag="BSU_35250" /old_locus_tag="BSU35250" /label="ftsX gene" downshifts complement(3275069) /Source="Nicolas_upshifts" /id="D1827" /incds=0 /nref=144 /ntot=253 /MaxReadThrough="3.3693" /MaxDrop="6.15417" /score="15.3496791" /energy="-14.6" /TU="U2763" /idTUdmin="U2763" /TUdmin="-102" /isTUend="FALSE" /label="downshifts" CDS complement(3275935..3276621) /gene="ftsE" /locus_tag="BSU_35260" /old_locus_tag="BSU35260" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16352817, 17071757, 17307852, 18573177, 22006326, 23855774, 27167971" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16352817, 17071757, 17307852, 18573177, 22006326, 23855774, 27167971; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="cell-division signal transducer (ATP-binding protein)" /protein_id="NP_391406.1" /db_xref="EnsemblGenomes-Gn:BSU35260" /db_xref="EnsemblGenomes-Tr:CAB15543" /db_xref="GOA:O34814" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR005286" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12590" /db_xref="UniProtKB/Swiss-Prot:O34814" /translation="MIEMKEVYKAYPNGVKALNGISVTIHPGEFVYVVGPSGAGKSTF IKMIYREEKPTKGQILINHKDLATIKEKEIPFVRRKIGVVFQDFKLLPKLTVFENVAF ALEVIGEQPSVIKKRVLEVLDLVQLKHKARQFPDQLSGGEQQRVSIARSIVNNPDVVI ADEPTGNLDPDTSWEVMKTLEEINNRGTTVVMATHNKEIVNTMKKRVIAIEDGIIVRD ESRGEYGSYD*" /label="ftsE CDS" gene complement(3275935..3276621) /gene="ftsE" /locus_tag="BSU_35260" /old_locus_tag="BSU35260" /label="ftsE gene" S_feature complement(3276622..3276754) /Source="Nicolas_S_feature" /locus_tag="new_3625508_3625640_c" /HighExp="Cold, UNK1, MG-0.2, MG 15, MG-0.1, C30, MG 25, MG 10, M9-exp, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA, SigA" /TUlongPSig="0.999, 0.998" /label="S1347" promotor_-10 complement(3276744..3276763) /Source="Nicolas_upshift_promotors" /id="U2763" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.9000999000999" /psig=1 /xcortree=2532 /SigmaFactorBS="atgccttgacaatatgaatgaaaagaaactgtaATAGtatta tgtctaaatTTGACGTATAATGAAGTGTAttgaaaaagggaactttcagatttttcat c" /listShort="S1347, ftsE, ftsX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3276754) /Source="Nicolas_upshifts" /id="U2763" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.9000999000999" /psig=1 /xcortree=2532 /SigmaFactorBS="atgccttgacaatatgaatgaaaagaaactgtaATAGtatta tgtctaaatTTGACGTATAATGAAGTGTAttgaaaaagggaactttcagatttttcat c" /listShort="S1347, ftsE, ftsX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3276778..3276781) /Source="Nicolas_upshift_promotors" /id="U2763" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.9000999000999" /psig=1 /xcortree=2532 /SigmaFactorBS="atgccttgacaatatgaatgaaaagaaactgtaATAGtatta tgtctaaatTTGACGTATAATGAAGTGTAttgaaaaagggaactttcagatttttcat c" /listShort="S1347, ftsE, ftsX" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3276855..3277193) /gene="cccB" /locus_tag="BSU_35270" /old_locus_tag="BSU35270" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:10473570, 19222757" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10473570, 19222757; Product type f: factor" /codon_start=1 /transl_table=11 /product="cytochrome c551" /protein_id="NP_391407.1" /db_xref="EnsemblGenomes-Gn:BSU35270" /db_xref="EnsemblGenomes-Tr:CAB15544" /db_xref="GOA:O34594" /db_xref="InterPro:IPR009056" /db_xref="InterPro:IPR012218" /db_xref="InterPro:IPR036909" /db_xref="SubtiList:BG12574" /db_xref="UniProtKB/Swiss-Prot:O34594" /translation="MKSKLSILMIGFALSVLLAACGSNDAKEEKTDTGSKTEATASEG EELYQQSCVGCHGKDLEGVSGPNLQEVGGKYDEHKIESIIKNGRGNMPKGLVDDNEAA VIAKWLSEKK*" /label="cccB CDS" gene complement(3276855..3277193) /gene="cccB" /locus_tag="BSU_35270" /old_locus_tag="BSU35270" /label="cccB gene" downshifts complement(3276856) /Source="Nicolas_upshifts" /id="D1828" /incds=0 /nref=192 /ntot=265 /MaxReadThrough="3.58546" /MaxDrop="6.88513" /score="18.0901387" /energy="-16.8" /TU="U2764" /idTUdmin="U2765" /TUdmin=3 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3277220..3277239) /Source="Nicolas_upshift_promotors" /id="U2764" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.56943056943057" /psig="0.999000999001" /xcortree=1617 /SigmaFactorBS="aattgtagcagacgcgagcgaggtgctgggcgaGGGTTTCAa acgcgcttaaacGAGGTTATAATATGGAAGAGatcgtaaaggagttgtgcttctcaac a" /listShort="cccB" /listLong="S1347, ftsE, ftsX" /label="promotor_-10" upshifts complement(3277233) /Source="Nicolas_upshifts" /id="U2764" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.56943056943057" /psig="0.999000999001" /xcortree=1617 /SigmaFactorBS="aattgtagcagacgcgagcgaggtgctgggcgaGGGTTTCAa acgcgcttaaacGAGGTTATAATATGGAAGAGatcgtaaaggagttgtgcttctcaac a" /listShort="cccB" /listLong="S1347, ftsE, ftsX" /label="upshifts" CDS complement(3277242..3278126) /gene="yvjA" /locus_tag="BSU_35280" /old_locus_tag="BSU35280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10473570, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391408.2" /db_xref="EnsemblGenomes-Gn:BSU35280" /db_xref="EnsemblGenomes-Tr:CAB15545" /db_xref="GOA:O34792" /db_xref="InterPro:IPR003740" /db_xref="InterPro:IPR019264" /db_xref="SubtiList:BG14109" /db_xref="UniProtKB/Swiss-Prot:O34792" /translation="MLSESIGRNGGYMMDVRNKTLWILRDYVYILIGAAITAVSFNVF LLPNKIAAGGVSGISTILQSYGFEAAYVQWIINIPLFIAGVILLGGKFGLKTLAGSVF LPLVVFLTRDIQPATHHELLAAIFGGVGIGIGIGIVYLGKGSTGGTALAAQIIHKYSG LSLGKCLAIIDGMIVVTAMIVFNIEQGLYAMLGVYVSSKTIDVVQVGFNRSKMALIIT KQEQAVKEAVLQKIDRGVTKISAVGGYTDDDRPILMCVVGQTEFTKLKQIVKQIDESA FVIVADASEVLGEGFKRA*" /label="yvjA CDS" gene complement(3277242..3278126) /gene="yvjA" /locus_tag="BSU_35280" /old_locus_tag="BSU35280" /label="yvjA gene" promotor_-35 complement(3277253..3277260) /Source="Nicolas_upshift_promotors" /id="U2764" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.56943056943057" /psig="0.999000999001" /xcortree=1617 /SigmaFactorBS="aattgtagcagacgcgagcgaggtgctgggcgaGGGTTTCAa acgcgcttaaacGAGGTTATAATATGGAAGAGatcgtaaaggagttgtgcttctcaac a" /listShort="cccB" /listLong="S1347, ftsE, ftsX" /label="promotor_-35" promotor_-10 complement(3278114..3278133) /Source="Nicolas_upshift_promotors" /id="U2765" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.975024975024975" /psig="0.998001998001998" /xcortree=2728 /SigmaFactorBS="ttcactgctgctttagcatattaccactgtatttgggtgtTA TTTACAtctaatcagggaagGATTAAAATGCTATCGGAGAgcattggaagaaacggag g" /listShort="yvjA, cccB" /listLong="S1347, ftsE, ftsX" /label="promotor_-10" upshifts complement(3278135) /Source="Nicolas_upshifts" /id="U2765" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.975024975024975" /psig="0.998001998001998" /xcortree=2728 /SigmaFactorBS="ttcactgctgctttagcatattaccactgtatttgggtgtTA TTTACAtctaatcagggaagGATTAAAATGCTATCGGAGAgcattggaagaaacggag g" /listShort="yvjA, cccB" /listLong="S1347, ftsE, ftsX" /label="upshifts" promotor_-35 complement(3278148..3278155) /Source="Nicolas_upshift_promotors" /id="U2765" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.975024975024975" /psig="0.998001998001998" /xcortree=2728 /SigmaFactorBS="ttcactgctgctttagcatattaccactgtatttgggtgtTA TTTACAtctaatcagggaagGATTAAAATGCTATCGGAGAgcattggaagaaacggag g" /listShort="yvjA, cccB" /listLong="S1347, ftsE, ftsX" /label="promotor_-35" CDS join(complement(3279283..3279354), complement(3278253..3279281)) /gene="prfB" /locus_tag="BSU_35290" /old_locus_tag="BSU35290" /experiment="publication(s) with functional evidences, PMID:1408743, 9696765, 9882663" /ribosomal_slippage /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1408743, 9696765, 9882663; Product type f: factor" /codon_start=1 /transl_table=11 /product="peptide chain release factor 2" /protein_id="NP_391409.1" /db_xref="EnsemblGenomes-Gn:BSU35290" /db_xref="EnsemblGenomes-Tr:CAB15546" /db_xref="GOA:P28367" /db_xref="InterPro:IPR000352" /db_xref="InterPro:IPR004374" /db_xref="InterPro:IPR005139" /db_xref="InterPro:IPR020853" /db_xref="SubtiList:BG10742" /db_xref="UniProtKB/Swiss-Prot:P28367" /translation="MELSEIRAELENMASRLADFRGSLDLESKEARIAELDEQMADPE FWNDQQKAQTVINEANGLKDYVNSYKKLNESHEELQMTHDLLKEEPDTDLQLELEKEL KSLTKEFNEFELQLLLSEPYDKNNAILELHPGAGGTESQDWGSMLLRMYTRWGERRGF KVETLDYLPGDEAGIKSVTLLIKGHNAYGYLKAEKGVHRLVRISPFDSSGRRHTSFVS CEVMPEFNDEIDIDIRTEDIKVDTYRASGAGGQHVNTTDSAVRITHLPTNVVVTCQTE RSQIKNRERAMKMLKAKLYQRRIEEQQAELDEIRGEQKEIGWGSQIRSYVFHPYSMVK DHRTNTEMGNVQAVMDGDIDTFIDAYLRSKLS*" /label="prfB CDS" gene complement(3278253..3279354) /gene="prfB" /locus_tag="BSU_35290" /old_locus_tag="BSU35290" /label="prfB gene" downshifts complement(3278269) /Source="Nicolas_upshifts" /id="D1829" /incds=0 /nref=193 /ntot=257 /MaxReadThrough="2.78016" /MaxDrop="6.41678" /score="27.1588259" /energy="-9.8" /TU="NA" /idTUdmin="U2766" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" S_feature complement(3279355..3279423) /Source="Nicolas_S_feature" /locus_tag="new_3628241_3628309_c" /HighExp="Etha, Sw, Cold, BC, G150, BI, dia15, Mt0, LBGtran, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH, SigEF, SigD" /TUshortPSig="0.994, 0.997, 1, 1" /TUlongSig="SigA, SigD" /TUlongPSig="0.999, 1" /label="S1348" CDS complement(3279424..3281949) /gene="secA" /locus_tag="BSU_35300" /old_locus_tag="BSU35300" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:9880811, 10074074, 10481054, 10559168, 10713435, 11021932, 12682299, 14621992, 16243836, 18923516, 23167435, 24592260, 26607006, 27336478" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9880811, 10074074, 10481054, 10559168, 10713435, 11021932, 12682299, 14621992, 16243836, 18923516, 23167435, 24592260, 26607006, 27336478; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="translocase binding subunit (ATPase)" /protein_id="NP_391410.1" /db_xref="EnsemblGenomes-Gn:BSU35300" /db_xref="EnsemblGenomes-Tr:CAB15547" /db_xref="GOA:P28366" /db_xref="InterPro:IPR000185" /db_xref="InterPro:IPR004027" /db_xref="InterPro:IPR011115" /db_xref="InterPro:IPR011116" /db_xref="InterPro:IPR011130" /db_xref="InterPro:IPR014018" /db_xref="InterPro:IPR020937" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036266" /db_xref="InterPro:IPR036670" /db_xref="PDB:1M6N" /db_xref="PDB:1M74" /db_xref="PDB:1TF2" /db_xref="PDB:1TF5" /db_xref="PDB:2IBM" /db_xref="PDB:3DL8" /db_xref="PDB:3IQM" /db_xref="PDB:3IQY" /db_xref="PDB:3JV2" /db_xref="PDB:5EUL" /db_xref="SubtiList:BG10741" /db_xref="UniProtKB/Swiss-Prot:P28366" /translation="MLGILNKMFDPTKRTLNRYEKIANDIDAIRGDYENLSDDALKHK TIEFKERLEKGATTDDLLVEAFAVVREASRRVTGMFPFKVQLMGGVALHDGNIAEMKT GEGKTLTSTLPVYLNALTGKGVHVVTVNEYLASRDAEQMGKIFEFLGLTVGLNLNSMS KDEKREAYAADITYSTNNELGFDYLRDNMVLYKEQMVQRPLHFAVIDEVDSILIDEAR TPLIISGQAAKSTKLYVQANAFVRTLKAEKDYTYDIKTKAVQLTEEGMTKAEKAFGID NLFDVKHVALNHHINQALKAHVAMQKDVDYVVEDGQVVIVDSFTGRLMKGRRYSEGLH QAIEAKEGLEIQNESMTLATITFQNYFRMYEKLAGMTGTAKTEEEEFRNIYNMQVVTI PTNRPVVRDDRPDLIYRTMEGKFKAVAEDVAQRYMTGQPVLVGTVAVETSELISKLLK NKGIPHQVLNAKNHEREAQIIEEAGQKGAVTIATNMAGRGTDIKLGEGVKELGGLAVV GTERHESRRIDNQLRGRSGRQGDPGITQFYLSMEDELMRRFGAERTMAMLDRFGMDDS TPIQSKMVSRAVESSQKRVEGNNFDSRKQLLQYDDVLRQQREVIYKQRFEVIDSENLR EIVENMIKSSLERAIAAYTPREELPEEWKLDGLVDLINTTYLDEGALEKSDIFGKEPD EMLELIMDRIITKYNEKEEQFGKEQMREFEKVIVLRAVDSKWMDHIDAMDQLRQGIHL RAYAQTNPLREYQMEGFAMFEHMIESIEDEVAKFVMKAEIENNLEREEVVQGQTTAHQ PQEGDDNKKAKKAPVRKVVDIGRNAPCHCGSGKKYKNCCGRTE*" /label="secA CDS" gene complement(3279424..3281949) /gene="secA" /locus_tag="BSU_35300" /old_locus_tag="BSU35300" /label="secA gene" S_feature complement(3281950..3282030) /Source="Nicolas_S_feature" /locus_tag="new_3630836_3630916_c" /HighExp="Etha, M9-stat, T0.30H, B60, dia5, Cold, dia15, Lbexp, Salt, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH, SigEF, SigD" /TUshortPSig="0.994, 0.997, 1, 1" /TUlongSig="SigA, SigD" /TUlongPSig="0.999, 1" /label="S1349" misc_feature complement(3282020..3282039) /Source="Nicolas_upshift_promotors" /id="U2766" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.69030969030969" /psig="0.994005994005994" /xcortree=106 /SigmaFactorBS="cggaaggtttttgtttttcttatttgcaaattctttggaaat aacaaaaggTATGATATGATAATGAGAGGtatacatggactagtaaattatttataca t" /listShort="S1349, secA, S1348, prfB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3282030) /Source="Nicolas_upshifts" /id="U2766" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.69030969030969" /psig="0.994005994005994" /xcortree=106 /SigmaFactorBS="cggaaggtttttgtttttcttatttgcaaattctttggaaat aacaaaaggTATGATATGATAATGAGAGGtatacatggactagtaaattatttataca t" /listShort="S1349, secA, S1348, prfB" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3282117..3282686) /gene="hpf" /locus_tag="BSU_35310" /old_locus_tag="BSU35310" /function="16.6: Maintain" /function="16.3: Control" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11948165, 16324148, 17274076, 17277072, 19747895, 22720735, 22950019, 28468753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11948165, 16324148, 17274076, 17277072, 19747895, 22720735, 22950019, 28468753; Product type f: factor" /codon_start=1 /transl_table=11 /product="ribosome-associated sigma 54 modulation protein;ribosome dimerisation factor" /protein_id="NP_391411.1" /db_xref="EnsemblGenomes-Gn:BSU35310" /db_xref="EnsemblGenomes-Tr:CAB15548" /db_xref="GOA:P28368" /db_xref="InterPro:IPR003489" /db_xref="InterPro:IPR032528" /db_xref="InterPro:IPR034694" /db_xref="InterPro:IPR036567" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10740" /db_xref="UniProtKB/Swiss-Prot:P28368" /translation="MNYNIRGENIEVTPALKDHVERKIGKLERYFDHSVDADVNVNLK FYNDKESKVEVTIPMTDLALRSEVHNEDMYNAIDLATNKLERQIRKHKTKVNRKFREQ GSPKYLLANGLGSDTDIAVQDDIEEEESLDIVRQKRFNLKPMDSEEAILQMNMLGHNF FVFTNAETNLTNVVYRRNDGKYGLIEPTE*" /label="hpf CDS" gene complement(3282117..3282686) /gene="hpf" /locus_tag="BSU_35310" /old_locus_tag="BSU35310" /label="hpf gene" downshifts complement(3282125) /Source="Nicolas_upshifts" /id="D1830" /incds=0 /nref=78 /ntot=209 /MaxReadThrough="8.66806" /MaxDrop="4.7023" /score="29.9030506" /energy="-12.2" /TU="U2768,U2769,U2770,U2773" /idTUdmin="U2773" /TUdmin="-74" /isTUend="FALSE" /label="downshifts" promotor_-35 3282653..3282659 /Source="Nicolas_upshift_promotors" /id="U2767" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.365634365634366" /psig="0.829170829170829" /xcortree=289 /SigmaFactorBS="ttcctctcgacatgatcctttaacgcgggtgtcaCTTCAATa ttttctcctctGATGTTATAGTTCATCAAAGaacgcctcccttttattaaggatatgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3282672..3282691 /Source="Nicolas_upshift_promotors" /id="U2767" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.365634365634366" /psig="0.829170829170829" /xcortree=289 /SigmaFactorBS="ttcctctcgacatgatcctttaacgcgggtgtcaCTTCAATa ttttctcctctGATGTTATAGTTCATCAAAGaacgcctcccttttattaaggatatgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3282679 /Source="Nicolas_upshifts" /id="U2767" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.365634365634366" /psig="0.829170829170829" /xcortree=289 /SigmaFactorBS="ttcctctcgacatgatcctttaacgcgggtgtcaCTTCAATa ttttctcctctGATGTTATAGTTCATCAAAGaacgcctcccttttattaaggatatgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3282713..3282731) /Source="Nicolas_upshift_promotors" /id="U2768" /multdbtbs="SigB,SigH" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=499 /SigmaFactorBS="actgaattttcacaaaagatttatgtttcaGCAGGAATTgta aagggtaaAAGAGAAATAGATACATATccttaataaaagggaggcgttctttgatgaa c" /listShort="yvyD, S1349, secA, S1348, prfB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3282721) /Source="Nicolas_upshifts" /id="U2768" /multdbtbs="SigB,SigH" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=499 /SigmaFactorBS="actgaattttcacaaaagatttatgtttcaGCAGGAATTgta aagggtaaAAGAGAAATAGATACATATccttaataaaagggaggcgttctttgatgaa c" /listShort="yvyD, S1349, secA, S1348, prfB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3282723..3282843) /Source="Nicolas_S_feature" /locus_tag="new_3631609_3631729_c" /HighExp="C30, M0t90, S4, Lbstat, S5, M40t90, Glucon, Gly, C90, GM 60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF, SigD, SigD" /TUshortPSig="1, 1, 1" /TUlongSig="SigA" /TUlongPSig="0.999" /label="S1350" promotor_-35 complement(3282743..3282751) /Source="Nicolas_upshift_promotors" /id="U2768" /multdbtbs="SigB,SigH" /comp="M1" /sig="SigH" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=499 /SigmaFactorBS="actgaattttcacaaaagatttatgtttcaGCAGGAATTgta aagggtaaAAGAGAAATAGATACATATccttaataaaagggaggcgttctttgatgaa c" /listShort="yvyD, S1349, secA, S1348, prfB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3282827..3282845) /Source="Nicolas_upshift_promotors" /id="U2769" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1221 /SigmaFactorBS="tgtatggaaccctttttaatcaattaggcgtgtgtgaGGTAT TtgtttcgttcaatcaGCATATACATATACCTCCGaaccgccaataacagagcaaata c" /listShort="S1350, yvyD, S1349, secA, S1348, prfB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3282843) /Source="Nicolas_upshifts" /id="U2769" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1221 /SigmaFactorBS="tgtatggaaccctttttaatcaattaggcgtgtgtgaGGTAT TtgtttcgttcaatcaGCATATACATATACCTCCGaaccgccaataacagagcaaata c" /listShort="S1350, yvyD, S1349, secA, S1348, prfB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3282861..3282866) /Source="Nicolas_upshift_promotors" /id="U2769" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1221 /SigmaFactorBS="tgtatggaaccctttttaatcaattaggcgtgtgtgaGGTAT TtgtttcgttcaatcaGCATATACATATACCTCCGaaccgccaataacagagcaaata c" /listShort="S1350, yvyD, S1349, secA, S1348, prfB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3282877..3283254) /gene="yvzG" /locus_tag="BSU_35319" /old_locus_tag="BSU35319" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097791.1" /db_xref="EnsemblGenomes-Gn:BSU35319" /db_xref="EnsemblGenomes-Tr:CAX52698" /db_xref="UniProtKB/Swiss-Prot:C0H3R9" /translation="MKSIEDYTLLSAYYHLLFTIEEGLCYLIEAEENLSKTEGDRIYQ DLIQAFFYLDSTHSTLLFIMDSRCAEICVKAFDQIFAEFDQLVSFSFPSHEFCEYLKE HFLIHYRKWMLSIHQCMEPFLIN*" /label="yvzG CDS" gene complement(3282877..3283254) /gene="yvzG" /locus_tag="BSU_35319" /old_locus_tag="BSU35319" /label="yvzG gene" CDS complement(3283264..3283605) /gene="fliT" /locus_tag="BSU_35320" /old_locus_tag="BSU35320" /function="16.3: Control" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12354229, 16952964; Product type s: structure" /codon_start=1 /transl_table=11 /product="flagellar assembly protein FliT involved in control of flagella expression" /protein_id="NP_391412.1" /db_xref="EnsemblGenomes-Gn:BSU35320" /db_xref="EnsemblGenomes-Tr:CAB15549" /db_xref="GOA:P39740" /db_xref="SubtiList:BG10923" /db_xref="UniProtKB/Swiss-Prot:P39740" /translation="MNNIDQLYTETKSMLSHIQNTPESDELLKQIEDFVATRSELIQE ISLPLSEEERKQMKLILTWDQLIVKEMERLKQSIATELQQMKRKRVMHTTYLNPYNNI TIDGTYYDKRK*" /label="fliT CDS" gene complement(3283264..3283605) /gene="fliT" /locus_tag="BSU_35320" /old_locus_tag="BSU35320" /label="fliT gene" CDS complement(3283602..3284003) /gene="fliS" /locus_tag="BSU_35330" /old_locus_tag="BSU35330" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12354229, 16806204, 16936039, 20534509, 23144244, 23874669; Product type s : structure" /codon_start=1 /transl_table=11 /product="flagellar assembly protein FliS" /protein_id="NP_391413.1" /db_xref="EnsemblGenomes-Gn:BSU35330" /db_xref="EnsemblGenomes-Tr:CAB15550" /db_xref="GOA:P39739" /db_xref="InterPro:IPR003713" /db_xref="InterPro:IPR036584" /db_xref="PDB:1VH6" /db_xref="SubtiList:BG10922" /db_xref="UniProtKB/Swiss-Prot:P39739" /translation="MAIQNPYTAYQQNSVNTATPGELTLMLYNGCLKFIRLAAQAIEN DDMERKNENLIKAQNIIQELNFTLNRNIELSASMGAMYDYMYRRLVQANIKNDTGMLA EVEGYVTDFRDAWKQAIQSERKDRHGSGGIA*" /label="fliS CDS" gene complement(3283602..3284003) /gene="fliS" /locus_tag="BSU_35330" /old_locus_tag="BSU35330" /label="fliS gene" CDS complement(3284025..3285521) /gene="fliD" /locus_tag="BSU_35340" /old_locus_tag="BSU35340" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9648743, 12354229, 24296669, 25355936; Product type s: structure" /codon_start=1 /transl_table=11 /product="flagellar hook-associated capping protein 2 (HAP2)" /protein_id="NP_391414.1" /db_xref="EnsemblGenomes-Gn:BSU35340" /db_xref="EnsemblGenomes-Tr:CAB15551" /db_xref="GOA:P39738" /db_xref="InterPro:IPR003481" /db_xref="InterPro:IPR010809" /db_xref="InterPro:IPR010810" /db_xref="SubtiList:BG10921" /db_xref="UniProtKB/Swiss-Prot:P39738" /translation="MVTRITGLASGMDIDDIVSKLMQTERAPLDKLTQKKQTLEWQRD SYREVNSKIKELQDYMSKNTLTYPSTYQSKTVTSSNESVLTATGSVSAPNSSSTVEVA SLATAATYKANNYTGYTQGDYNLAFNVVAPGETTAKTVNISVTSADTIDNVISKLNSS DLGVSAFKDKIWNGTEYVETIAFSSKATGAGGSIQAADSATADFMSGQLGFSLDADNK LTAYKEGTNAKVTINGFEMEKLTNNFTVNGVTYSIKNTTAATGPVTTSVSTDVDGIYN QIKEFVDKYNELVDSLNEKLKEEKYRDYTPLTSEQKEAMSDKEVELWEEKAKSGLLRN DSSISTGTNQMRTDFYTQVNADGKTYQLTEFGITTSSAYQLRGHLEINEEKLKAKIAE DPQGVANLFTSGTNDSNYSDKGIMKRITNTLRSTVKSIEAKAGNSTMGASSYSIGKNL NSISTEITDMQDRLNTIENRYYSKFSAMDSAIQKMNEQASYLSQLLVQ*" /label="fliD CDS" gene complement(3284025..3285521) /gene="fliD" /locus_tag="BSU_35340" /old_locus_tag="BSU35340" /label="fliD gene" CDS complement(3285539..3285868) /gene="yvyC" /locus_tag="BSU_35350" /old_locus_tag="BSU35350" /function="16.13: Shape" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12354229, 19455708; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative flagellar protein of unknown function" /protein_id="NP_391415.1" /db_xref="EnsemblGenomes-Gn:BSU35350" /db_xref="EnsemblGenomes-Tr:CAB15552" /db_xref="InterPro:IPR005186" /db_xref="InterPro:IPR035924" /db_xref="PDB:2HC5" /db_xref="SubtiList:BG10920" /db_xref="UniProtKB/Swiss-Prot:P39737" /translation="MNIERLTTLQPVWDRYDTQIHNQKDNDNEVPVHQVSYTNLAEMV GEMNKLLEPSQVHLKFELHDKLNEYYVKVIEDSTNEVIREIPPKRWLDFYAAMTEFLG LFVDEKK*" /label="yvyC CDS" gene complement(3285539..3285868) /gene="yvyC" /locus_tag="BSU_35350" /old_locus_tag="BSU35350" /label="yvyC gene" downshifts 3285865 /Source="Nicolas_upshifts" /id="D1831" /incds=0 /nref=33 /ntot=140 /MaxReadThrough="2.74277" /MaxDrop="4.24086" /score="8.30527041" /energy="-10.1" /TU="NA" /idTUdmin="U2774" /TUdmin="-3062" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3285890..3285908) /Source="Nicolas_upshift_promotors" /id="U2770" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2807 /SigmaFactorBS="agaaatctaaaacagaagatttttttccaaaaatatGTGTAA TCttatctcgacttaGTCGATATAAACGATAGATtggggcataggggatgatcaattg a" /listShort="yvyC, fliD, fliS, fliT, yvzG, S1350, yvyD, S1349, secA, S1348, prfB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3285905) /Source="Nicolas_upshifts" /id="U2770" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2807 /SigmaFactorBS="agaaatctaaaacagaagatttttttccaaaaatatGTGTAA TCttatctcgacttaGTCGATATAAACGATAGATtggggcataggggatgatcaattg a" /listShort="yvyC, fliD, fliS, fliT, yvzG, S1350, yvyD, S1349, secA, S1348, prfB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3285907..3286011) /Source="Nicolas_S_feature" /locus_tag="new_3634793_3634897_c" /HighExp="Lbstat, Cold, Gly, S0, Glu, Pyr, M/G, M0t90, C30, Fru" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1351" promotor_-35 complement(3285922..3285929) /Source="Nicolas_upshift_promotors" /id="U2770" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2807 /SigmaFactorBS="agaaatctaaaacagaagatttttttccaaaaatatGTGTAA TCttatctcgacttaGTCGATATAAACGATAGATtggggcataggggatgatcaattg a" /listShort="yvyC, fliD, fliS, fliT, yvzG, S1350, yvyD, S1349, secA, S1348, prfB" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(3286000..3286019) /Source="Nicolas_upshift_promotors" /id="U2771" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.498501498501498" /psig="0.999000999001" /xcortree=2693 /SigmaFactorBS="tcttttaatttaaatttctatctcctaatcattcctcatcct gtcactaactCATGATATAATAACCGGATTctccactaactttttataaatgtatttc c" /listShort="S1351, yvyC, fliD, fliS, fliT, yvzG" /listLong="S1350, yvyD, S1349, secA, S1348, prfB" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3286011) /Source="Nicolas_upshifts" /id="U2771" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.498501498501498" /psig="0.999000999001" /xcortree=2693 /SigmaFactorBS="tcttttaatttaaatttctatctcctaatcattcctcatcct gtcactaactCATGATATAATAACCGGATTctccactaactttttataaatgtatttc c" /listShort="S1351, yvyC, fliD, fliS, fliT, yvzG" /listLong="S1350, yvyD, S1349, secA, S1348, prfB" /label="upshifts" CDS complement(3286101..3287015) /gene="hag" /locus_tag="BSU_35360" /old_locus_tag="BSU35360" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:8045886, 9648743, 12730172, 14762011, 15342569, 22720735, 25355936, 28800172, 29124898" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045886, 9648743, 12730172, 14762011, 15342569, 22720735, 25355936, 28800172, 29124898; Product type s: structure" /codon_start=1 /transl_table=11 /product="flagellin protein" /protein_id="NP_391416.1" /db_xref="EnsemblGenomes-Gn:BSU35360" /db_xref="EnsemblGenomes-Tr:CAB15553" /db_xref="GOA:P02968" /db_xref="InterPro:IPR001029" /db_xref="InterPro:IPR001492" /db_xref="SubtiList:BG10655" /db_xref="UniProtKB/Swiss-Prot:P02968" /translation="MRINHNIAALNTLNRLSSNNSASQKNMEKLSSGLRINRAGDDAA GLAISEKMRGQIRGLEMASKNSQDGISLIQTAEGALTETHAILQRVRELVVQAGNTGT QDKATDLQSIQDEISALTDEIDGISNRTEFNGKKLLDGTYKVDTATPANQKNLVFQIG ANATQQISVNIEDMGADALGIKEADGSIAALHSVNDLDVTKFADNAADTADIGFDAQL KVVDEAINQVSSQRAKLGAVQNRLEHTINNLSASGENLTAAESRIRDVDMAKEMSEFT KNNILSQASQAMLAQANQQPQNVLQLLR*" /label="hag CDS" gene complement(3286101..3287015) /gene="hag" /locus_tag="BSU_35360" /old_locus_tag="BSU35360" /label="hag gene" downshifts complement(3286121) /Source="Nicolas_upshifts" /id="D1832" /incds=0 /nref=165 /ntot=233 /MaxReadThrough="5.58531" /MaxDrop="7.10921" /score="11.6997504" /energy="-13.1" /TU="U2773" /idTUdmin="U2775" /TUdmin=1078 /isTUend="FALSE" /label="downshifts" S_feature complement(3287016..3287124) /Source="Nicolas_S_feature" /locus_tag="new_3635902_3636010_c" /HighExp="T2.0H, Glucon, M0t90, T2.30H, GM 15, T-0.40H, GM 10, T1.0H, T-1.10H, C90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1352" promotor_-35 3287082..3287083 /Source="Nicolas_upshift_promotors" /id="U2772" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.997002997002997" /psig=0 /xcortree=717 /SigmaFactorBS="gttaaggcacgtccttgtgcccttattttgtaactggctgaG TcttttgcgCCTCCTCCCGGCTACatcattaatatcggattgtctctgattttgttaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3287092..3287106 /Source="Nicolas_upshift_promotors" /id="U2772" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.997002997002997" /psig=0 /xcortree=717 /SigmaFactorBS="gttaaggcacgtccttgtgcccttattttgtaactggctgaG TcttttgcgCCTCCTCCCGGCTACatcattaatatcggattgtctctgattttgttaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3287101 /Source="Nicolas_upshifts" /id="U2772" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.997002997002997" /psig=0 /xcortree=717 /SigmaFactorBS="gttaaggcacgtccttgtgcccttattttgtaactggctgaG TcttttgcgCCTCCTCCCGGCTACatcattaatatcggattgtctctgattttgttaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3287103..3287121) /Source="Nicolas_upshift_promotors" /id="U2773" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2833 /SigmaFactorBS="cgcattatcctcacaaaaaaagtgaggatttttttatttttg tATTAACAAaatcagagacaaTCCGATATTAATGATGTAGccgggaggaggcgcaaaa g" /listShort="S1352, hag, S1351, yvyC, fliD, fliS, fliT, yvzG, S1350, yvyD" /listLong="S1349, secA, S1348, prfB" /label="promotor_-10" upshifts complement(3287124) /Source="Nicolas_upshifts" /id="U2773" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2833 /SigmaFactorBS="cgcattatcctcacaaaaaaagtgaggatttttttatttttg tATTAACAAaatcagagacaaTCCGATATTAATGATGTAGccgggaggaggcgcaaaa g" /listShort="S1352, hag, S1351, yvyC, fliD, fliS, fliT, yvzG, S1350, yvyD" /listLong="S1349, secA, S1348, prfB" /label="upshifts" promotor_-35 complement(3287134..3287141) /Source="Nicolas_upshift_promotors" /id="U2773" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2833 /SigmaFactorBS="cgcattatcctcacaaaaaaagtgaggatttttttatttttg tATTAACAAaatcagagacaaTCCGATATTAATGATGTAGccgggaggaggcgcaaaa g" /listShort="S1352, hag, S1351, yvyC, fliD, fliS, fliT, yvzG, S1350, yvyD" /listLong="S1349, secA, S1348, prfB" /label="promotor_-35" CDS complement(3287160..3287384) /gene="csrA" /locus_tag="BSU_35370" /old_locus_tag="BSU35370" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8982093, 17555441, 21895793, 23144244, 27516547" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8982093, 17555441, 21895793, 23144244, 27516547; Product type r: regulator" /codon_start=1 /transl_table=11 /product="carbon storage regulator" /protein_id="NP_391417.1" /db_xref="EnsemblGenomes-Gn:BSU35370" /db_xref="EnsemblGenomes-Tr:CAB15554" /db_xref="GOA:P33911" /db_xref="InterPro:IPR003751" /db_xref="InterPro:IPR036107" /db_xref="PDB:1T3O" /db_xref="SubtiList:BG10654" /db_xref="UniProtKB/Swiss-Prot:P33911" /translation="MLVLSRKINEAIQIGADIEVKVIAVEGDQVKLGIDAPKHIDIHR KEIYLTIQEENNRAAALSSDVISALSSQKK*" /label="csrA CDS" gene complement(3287160..3287384) /gene="csrA" /locus_tag="BSU_35370" /old_locus_tag="BSU35370" /label="csrA gene" downshifts complement(3287199) /Source="Nicolas_upshifts" /id="D1833" /incds=0 /nref=22 /ntot=171 /MaxReadThrough="2.28652" /MaxDrop="3.46262" /score="31.5820557" /energy="-9.2" /TU="NA" /idTUdmin="U2775" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3287378..3287809) /gene="fliW" /locus_tag="BSU_35380" /old_locus_tag="BSU35380" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15033535, 16936039, 21895793, 27516547" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15033535, 16936039, 21895793, 27516547; Product type f: factor" /codon_start=1 /transl_table=11 /product="assembly factor of the flagellum" /protein_id="NP_391418.1" /db_xref="EnsemblGenomes-Gn:BSU35380" /db_xref="EnsemblGenomes-Tr:CAB15555" /db_xref="GOA:P96503" /db_xref="InterPro:IPR003775" /db_xref="InterPro:IPR024046" /db_xref="SubtiList:BG12451" /db_xref="UniProtKB/Swiss-Prot:P96503" /translation="MIIHTKYHGQMNIKEEQIILFESGIPGFLEEKQFVILPLSEDSP FVALQSVTSENLAFIVVSPFIFFKNYEFDLDESTAELLDIDNIQDVEVMTILTMAEPF EKSTANLLAPIIVNRKNMMAKQVVLHDSSYTTKHPIGGESC*" /label="fliW CDS" gene complement(3287378..3287809) /gene="fliW" /locus_tag="BSU_35380" /old_locus_tag="BSU35380" /label="fliW gene" CDS complement(3287830..3288405) /gene="yviE" /locus_tag="BSU_35390" /old_locus_tag="BSU35390" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15033535" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391419.1" /db_xref="EnsemblGenomes-Gn:BSU35390" /db_xref="EnsemblGenomes-Tr:CAB15556" /db_xref="SubtiList:BG12450" /db_xref="UniProtKB/Swiss-Prot:P96502" /translation="MQIPRLIMHSVQGKIGLTTTPASLKMEQPQADLEIEQPSAEMEI SVTPGKLTIDQTQAWEELDRKHVFKRIEEAAQQGHEDVMEGIARTAEEGDELMKIENK GNPIASQARRNSEMHQIQLGENYAPSLSRVKIQYTPSQLDVQITPRKPVIQAEPHKPI VEYTPGNVKVDMLQYPDLNIDVEYPKESPEK*" /label="yviE CDS" gene complement(3287830..3288405) /gene="yviE" /locus_tag="BSU_35390" /old_locus_tag="BSU35390" /label="yviE gene" CDS complement(3288452..3289348) /gene="flgL" /locus_tag="BSU_35400" /old_locus_tag="BSU35400" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2407720, 15033535, 17438286, 23874669, 24296669, 24706744; Product type s : structure" /codon_start=1 /transl_table=11 /product="flagellar hook-filament junction protein" /protein_id="NP_391420.1" /db_xref="EnsemblGenomes-Gn:BSU35400" /db_xref="EnsemblGenomes-Tr:CAB15557" /db_xref="GOA:P96501" /db_xref="InterPro:IPR001029" /db_xref="InterPro:IPR013384" /db_xref="SubtiList:BG11936" /db_xref="UniProtKB/Swiss-Prot:P96501" /translation="MRVTQGMIQQNSLRYIGSSYSKLDKLQSQISSGKKISKASDDPV VAMKSLKYNTQLSQVQQYKSNASQAFTWLENTETNITEGIDILSKVRELAVEAQNDTN GEPERQAIGVEVKQLKEQLLNIANTQVNGRYIFNGTNSDKPPVTDNGDGTYTISDTAD VVVNISNNMSLKVNSDPKSAFGGTSESGQNVFEMLDSFEKALNSGSLDGMDSVLNDID HFSDGMSAERSDLGARYNRLELVNTRLSAQEETATKVLSDNEDVELEEVITEFIAQQS VHRATLAVNAQIVQPTLIDFLK*" /label="flgL CDS" gene complement(3288452..3289348) /gene="flgL" /locus_tag="BSU_35400" /old_locus_tag="BSU35400" /label="flgL gene" downshifts complement(3288475) /Source="Nicolas_upshifts" /id="D1834" /incds=0 /nref=112 /ntot=251 /MaxReadThrough="5.50861" /MaxDrop="3.8234" /score="0.376587888" /energy="-4.8" /TU="U2775,U2776,U2777" /idTUdmin="U2777" /TUdmin="-1254" /isTUend="FALSE" /label="downshifts" misc_feature 3288764..3288767 /Source="Nicolas_upshift_promotors" /id="U2774" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.97902097902098" /psig="0.000999000999001" /xcortree=54 /SigmaFactorBS="actgtccatgccatctagcgaaccagaatttagtgctttctc aaaagaatcAAGCatttcaaatacattctgcccgctttcagaagtgcctccaaaagct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3288773 /Source="Nicolas_upshifts" /id="U2774" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.97902097902098" /psig="0.000999000999001" /xcortree=54 /SigmaFactorBS="actgtccatgccatctagcgaaccagaatttagtgctttctc aaaagaatcAAGCatttcaaatacattctgcccgctttcagaagtgcctccaaaagct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3289359..3290882) /gene="flgK" /locus_tag="BSU_35410" /old_locus_tag="BSU35410" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2407720, 15033535, 17438286, 23874669, 24296669, 24706744; Product type s : structure" /codon_start=1 /transl_table=11 /product="flagellar hook-filament junction" /protein_id="NP_391421.1" /db_xref="EnsemblGenomes-Gn:BSU35410" /db_xref="EnsemblGenomes-Tr:CAB15558" /db_xref="GOA:P39810" /db_xref="InterPro:IPR001444" /db_xref="InterPro:IPR002371" /db_xref="InterPro:IPR010930" /db_xref="InterPro:IPR019776" /db_xref="SubtiList:BG10401" /db_xref="UniProtKB/Swiss-Prot:P39810" /translation="MTSTFMGLETARRALSAQQAALSTTANNVANANTDGYTRQRVSL EATDYFPAVSKNAEKTAGQMGTGVQGKSVERIRDIFLDYQYRLQNNSAGYYDTKAKAL SQMEGVLNETDDSGLNSVLNSFWNSLQELSNNTNEESARSVVARKGQAVAETFNYISE SLTNVQSNLKAELNTTVLDVNSLLSQLNSLNKQIAQVEPVGLLPNGLYDQRDLLIDKL SSMVDIKVSYNKSGGNALASAEGTVSIEILDKNKQSLGTVLDGKNYEVSELAANYDNE TGLVSSISIGDTAVQAESFSSKGSLLGFIESYGYITADGQEKGVYPEMLSDLDNMALE FAKAFNEVHRNGVTKSGEQGGDFFDFTGGETEPAKGAAGKIKVADSIIDSKGANIAFS LTGAANDNANATKLANVLTGKITINGKETSVLDYYAGLIGELGIEAQEANRLASNTET QLNDADINRQQMSAVSLDEEMTNMIQFQHAYNAAARMVTLQDELLDKVINGMGVGGR* " /label="flgK CDS" gene complement(3289359..3290882) /gene="flgK" /locus_tag="BSU_35410" /old_locus_tag="BSU35410" /label="flgK gene" CDS complement(3290901..3291383) /gene="flgN" /locus_tag="BSU_35420" /old_locus_tag="BSU35420" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:24706744" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 24706744; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor required for flagellar based motility" /protein_id="NP_391422.1" /db_xref="EnsemblGenomes-Gn:BSU35420" /db_xref="EnsemblGenomes-Tr:CAB15559" /db_xref="GOA:P39808" /db_xref="InterPro:IPR007809" /db_xref="InterPro:IPR036679" /db_xref="SubtiList:BG10400" /db_xref="UniProtKB/Swiss-Prot:P39808" /translation="MSAKAIIEQLKRLCVLHEHLLTLSEEKTEALKAGKTKELSNILT KEQKYIQAITQTEDDRIKTTSAFLGYSENNTISACIAKTSGSEKEELEQLYESLSQVL GRLKKVNEMNRQLTRDALQFISISYDMLVPKENNFNYSKSIKAELPKSSKMKLFDSKA *" /label="flgN CDS" gene complement(3290901..3291383) /gene="flgN" /locus_tag="BSU_35420" /old_locus_tag="BSU35420" /label="flgN gene" CDS complement(3291399..3291665) /gene="flgM" /locus_tag="BSU_35430" /old_locus_tag="BSU35430" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10207036, 10322161, 14762011, 16673084, 21736639, 22720735, 25313396" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10207036, 10322161, 14762011, 16673084, 21736639, 22720735, 25313396; Product type r: regulator" /codon_start=1 /transl_table=11 /product="anti-sigma factor repressor of sigma(D)-dependent transcription" /protein_id="NP_391423.1" /db_xref="EnsemblGenomes-Gn:BSU35430" /db_xref="EnsemblGenomes-Tr:CAB15560" /db_xref="GOA:P39809" /db_xref="InterPro:IPR007412" /db_xref="InterPro:IPR031316" /db_xref="InterPro:IPR035890" /db_xref="SubtiList:BG10399" /db_xref="UniProtKB/Swiss-Prot:P39809" /translation="MKINQFGTQSVNPYQKNYDKQAVQKTVAQPQDKIEISSQAKEMQ HASDAVTGSRQEKIAQLKAQIENGSYKVDANHIAKNMINFYKKQ*" /label="flgM CDS" gene complement(3291399..3291665) /gene="flgM" /locus_tag="BSU_35430" /old_locus_tag="BSU35430" /label="flgM gene" S_feature complement(3291666..3291745) /Source="Nicolas_S_feature" /locus_tag="new_3640552_3640631_c" /HighExp="T0.30H, Cold, C90, T-5.40H, T-4.40H, GM 150, T-2.40H, GM 45, S2, GM 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigA, SigA" /TUshortPSig="1, 1, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1353" CDS complement(3291746..3292165) /gene="yvyF" /locus_tag="BSU_35440" /old_locus_tag="BSU35440" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9696775; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator of flagella formation" /protein_id="NP_391424.1" /db_xref="EnsemblGenomes-Gn:BSU35440" /db_xref="EnsemblGenomes-Tr:CAB15561" /db_xref="GOA:P39807" /db_xref="InterPro:IPR022258" /db_xref="SubtiList:BG10398" /db_xref="UniProtKB/Swiss-Prot:P39807" /translation="MGELANCPKCNALFLKTKLQTVCQACIKEEEKSFETVYKFLRKQ ENRQSTLSRITEETGVEEELILKFIRQKRIQITHLPNLAYPCERCGTSIREGKFCKAC QSDIKDQMDHLNHEDALKIEKENSKKDTYYAYNTKNS*" /label="yvyF CDS" gene complement(3291746..3292165) /gene="yvyF" /locus_tag="BSU_35440" /old_locus_tag="BSU35440" /label="yvyF gene" promotor_-10 complement(3292204..3292222) /Source="Nicolas_upshift_promotors" /id="U2775" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2812 /SigmaFactorBS="cgcttcagtgtcatcttttaccttgatcagaaGCTAAATGat tctgtttttatGCCGATATAATCACTAGAAattgacacaggcatattatctaataagg a" /listShort="yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3292215) /Source="Nicolas_upshifts" /id="U2775" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2812 /SigmaFactorBS="cgcttcagtgtcatcttttaccttgatcagaaGCTAAATGat tctgtttttatGCCGATATAATCACTAGAAattgacacaggcatattatctaataagg a" /listShort="yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3292236..3292243) /Source="Nicolas_upshift_promotors" /id="U2775" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2812 /SigmaFactorBS="cgcttcagtgtcatcttttaccttgatcagaaGCTAAATGat tctgtttttatGCCGATATAATCACTAGAAattgacacaggcatattatctaataagg a" /listShort="yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3292239..3292961) /gene="comFC" /locus_tag="BSU_35450" /old_locus_tag="BSU35450" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8045879, 8412657, 16009133, 28618091" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045879, 8412657, 16009133, 28618091; Product type t: transporter" /codon_start=1 /transl_table=11 /product="component of the DNA transport apparatus" /protein_id="NP_391425.2" /db_xref="EnsemblGenomes-Gn:BSU35450" /db_xref="EnsemblGenomes-Tr:CAB15562" /db_xref="GOA:P39147" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR005222" /db_xref="InterPro:IPR029057" /db_xref="SubtiList:BG10397" /db_xref="UniProtKB/Swiss-Prot:P39147" /translation="MSNEAGGGIHKLICLLCDSQFSQDVTWRALFLLKPDEKVCYSCR SKLKKITGHICPLCGRPQSVHAVCRDCEVWRTRIRDSLLLRQNRSVYTYNDMMKETLS RFKFRGDAEIINAFKSDFSSTFSKVYPDKHFVLVPIPLSKEREEERGFNQAHLLAECL DRPSHHPLIRLNNEKQSKKKKTERLLSECIFDTKNNSAEGMNIILIDDLYTTGATLHF AARCLLEKGKAASVSSFTLIRS*" /label="comFC CDS" gene complement(3292239..3292961) /gene="comFC" /locus_tag="BSU_35450" /old_locus_tag="BSU35450" /label="comFC gene" CDS complement(3292925..3293221) /gene="comFB" /locus_tag="BSU_35460" /old_locus_tag="BSU35460" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8045879, 8412657, 16009133, 25423369" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045879, 8412657, 16009133, 25423369; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of competence, pole located" /protein_id="NP_391426.1" /db_xref="EnsemblGenomes-Gn:BSU35460" /db_xref="EnsemblGenomes-Tr:CAB15563" /db_xref="GOA:P39146" /db_xref="InterPro:IPR019657" /db_xref="PDB:4WAI" /db_xref="SubtiList:BG10396" /db_xref="UniProtKB/Swiss-Prot:P39146" /translation="MLVNSKEIVMKELLDRYMDQLHMACTCQVCQNDVLALSLNKVSP SYVTDFKKIAYTKAELVDKQKNTAMLVILAESAAVVSESPSDLCQTKQEEAFIN*" /label="comFB CDS" gene complement(3292925..3293221) /gene="comFB" /locus_tag="BSU_35460" /old_locus_tag="BSU35460" /label="comFB gene" promotor_-10 complement(3293247..3293266) /Source="Nicolas_upshift_promotors" /id="U2776" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.797202797202797" /psig=1 /xcortree=2253 /SigmaFactorBS="aatgaatgaattggcagcaaaagttgaatgtacagaCTAGCC ATtatttgaaaaCGTGGTACAGTATACTCATAtaaccgatgatgaggagctgtaaaaa t" /listShort="comFB, comFC, yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3293260) /Source="Nicolas_upshifts" /id="U2776" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.797202797202797" /psig=1 /xcortree=2253 /SigmaFactorBS="aatgaatgaattggcagcaaaagttgaatgtacagaCTAGCC ATtatttgaaaaCGTGGTACAGTATACTCATAtaaccgatgatgaggagctgtaaaaa t" /listShort="comFB, comFC, yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3293277..3293284) /Source="Nicolas_upshift_promotors" /id="U2776" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.797202797202797" /psig=1 /xcortree=2253 /SigmaFactorBS="aatgaatgaattggcagcaaaagttgaatgtacagaCTAGCC ATtatttgaaaaCGTGGTACAGTATACTCATAtaaccgatgatgaggagctgtaaaaa t" /listShort="comFB, comFC, yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3293281..3294672) /gene="comFA" /locus_tag="BSU_35470" /old_locus_tag="BSU35470" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8045895, 11359569, 12123453, 16009133, 21397556, 28559293" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045895, 11359569, 12123453, 16009133, 21397556, 28559293; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent helicase competence protein" /protein_id="NP_391427.1" /db_xref="EnsemblGenomes-Gn:BSU35470" /db_xref="EnsemblGenomes-Tr:CAB15564" /db_xref="GOA:P39145" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR006935" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10395" /db_xref="UniProtKB/Swiss-Prot:P39145" /translation="MNVPVEKNSSFSKELQQTLRSRHLLRTELSFSDEMIEWHIKNGY ITAENSISINKRRYRCNRCGQTDQRYFSFYHSSGKNKLYCRSCVMMGRVSEEVPLYSW KEENESNWKSIKLTWDGKLSSGQQKAANVLIEAISKKEELLIWAVCGAGKTEMLFPGI ESALNQGLRVCIATPRTDVVLELAPRLKAAFQGADISALYGGSDDKGRLSPLMISTTH QLLRYKDAIDVMIIDEVDAFPYSADQTLQFAVQKARKKNSTLVYLSATPPKELKRKAL NGQLHSVRIPARHHRKPLPEPRFVWCGNWKKKLNRNKIPPAVKRWIEFHVKEGRPVFL FVPSVSILEKAAACFKGVHCRTASVHAEDKHRKEKVQQFRDGQLDLLITTTILERGVT VPKVQTGVLGAESSIFTESALVQIAGRTGRHKEYADGDVIYFHFGKTKSMLDARKHIK EMNELAAKVECTD*" /label="comFA CDS" gene complement(3293281..3294672) /gene="comFA" /locus_tag="BSU_35470" /old_locus_tag="BSU35470" /label="comFA gene" promotor_-10 complement(3294686..3294705) /Source="Nicolas_upshift_promotors" /id="U2777" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.992007992007992" /psig="0.997002997002997" /xcortree=2970 /SigmaFactorBS="ttagagcggagatttttttatattcttattttaatAGTTGGA CagaaaatattcatTCAGGCATACTGTTTCGAAAggaggcgtgctatgtgaatgtgcc a" /listShort="comFA, comFB, comFC, yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3294701) /Source="Nicolas_upshifts" /id="U2777" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.992007992007992" /psig="0.997002997002997" /xcortree=2970 /SigmaFactorBS="ttagagcggagatttttttatattcttattttaatAGTTGGA CagaaaatattcatTCAGGCATACTGTTTCGAAAggaggcgtgctatgtgaatgtgcc a" /listShort="comFA, comFB, comFC, yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3294719..3294726) /Source="Nicolas_upshift_promotors" /id="U2777" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.992007992007992" /psig="0.997002997002997" /xcortree=2970 /SigmaFactorBS="ttagagcggagatttttttatattcttattttaatAGTTGGA CagaaaatattcatTCAGGCATACTGTTTCGAAAggaggcgtgctatgtgaatgtgcc a" /listShort="comFA, comFB, comFC, yvyF, S1353, flgM, yvyG, flgK, flgL, yviE, fliW, csrA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3294778..3295623) /gene="fakBA" /locus_tag="BSU_35480" /old_locus_tag="BSU35480" /EC_number="2.7.2.-" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:3926750, 17114254, 19390149, 22720735, 25002480, 26774272, 27435445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3926750, 17114254, 19390149, 22720735, 25002480, 26774272, 27435445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fatty acid kinase fatty acid binding subunit A" /protein_id="NP_391428.1" /db_xref="EnsemblGenomes-Gn:BSU35480" /db_xref="EnsemblGenomes-Tr:CAB15565" /db_xref="GOA:P32436" /db_xref="InterPro:IPR003797" /db_xref="PDB:3FYS" /db_xref="SubtiList:BG10394" /db_xref="UniProtKB/Swiss-Prot:P32436" /translation="MNIAVVTDSTAYIPKEMREQHQIHMIPLQVVFREETYREEIELD WKSFYEEVKKHNELPTTSQPPIGELVALYEELGKSYDAVISIHLSSGISGTFSSAAAA DSMVDNIDVYPFDSEISCLAQGFYALKAAELIKNGASSPEDIIKELEEMKKTVRAYFM VDDLAHLQRGGRLSSAQAFIGSLLKVKPILHFDNKVIVPFEKIRTRKKAISRIYELLD EDASKGLPMRAAVIHANREEEAAKIIEELSAKYPHVEFYNSYFGAVIGTHLGEGALGI CWCFK*" /label="fakBA CDS" gene complement(3294778..3295623) /gene="fakBA" /locus_tag="BSU_35480" /old_locus_tag="BSU35480" /label="fakBA gene" downshifts complement(3294789) /Source="Nicolas_upshifts" /id="D1835" /incds=0 /nref=207 /ntot=249 /MaxReadThrough="2.43976" /MaxDrop="5.65998" /score="25.7738948" /energy="-9.9" /TU="NA" /idTUdmin="U2779" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 3295040..3295047 /Source="Nicolas_upshift_promotors" /id="U2778" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.897102897102897" /psig="0.978021978021978" /xcortree=2971 /SigmaFactorBS="tgcgaatcttctcaaaaggcacaattaccTTATTGTCaaaat gaaggataGGCTTTACCTTTAGAAGACTaccaatgaaggcttgggcgctgcttaatcg c" /listShort="S1354" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3295061..3295080 /Source="Nicolas_upshift_promotors" /id="U2778" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.897102897102897" /psig="0.978021978021978" /xcortree=2971 /SigmaFactorBS="tgcgaatcttctcaaaaggcacaattaccTTATTGTCaaaat gaaggataGGCTTTACCTTTAGAAGACTaccaatgaaggcttgggcgctgcttaatcg c" /listShort="S1354" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3295071..3296803 /Source="Nicolas_S_feature" /locus_tag="new_3643957_3645689" /HighExp="C30, S2, C90, Pyr, T0.30H, GM 150, G/S, T-4.40H, T-3.40H, T1.30H" /AntisenseName="degU" /AntisenseCor="1.0564647169900101E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.978" /TUlongSig="NA" /TUlongPSig="NA" /label="S1354" upshifts 3295071 /Source="Nicolas_upshifts" /id="U2778" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.897102897102897" /psig="0.978021978021978" /xcortree=2971 /SigmaFactorBS="tgcgaatcttctcaaaaggcacaattaccTTATTGTCaaaat gaaggataGGCTTTACCTTTAGAAGACTaccaatgaaggcttgggcgctgcttaatcg c" /listShort="S1354" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3295650..3295669) /Source="Nicolas_upshift_promotors" /id="U2779" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.998001998001998" /xcortree=2329 /SigmaFactorBS="atgagatagtataataggagacttgccttttactaggcaggt CTTTttttaggctgccgtTTCCCTTACAATAGAGTTATaaagcaataaggcaggtatc g" /listShort="yviA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3295669) /Source="Nicolas_upshifts" /id="U2779" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.998001998001998" /xcortree=2329 /SigmaFactorBS="atgagatagtataataggagacttgccttttactaggcaggt CTTTttttaggctgccgtTTCCCTTACAATAGAGTTATaaagcaataaggcaggtatc g" /listShort="yviA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3295684..3295687) /Source="Nicolas_upshift_promotors" /id="U2779" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.767232767232767" /psig="0.998001998001998" /xcortree=2329 /SigmaFactorBS="atgagatagtataataggagacttgccttttactaggcaggt CTTTttttaggctgccgtTTCCCTTACAATAGAGTTATaaagcaataaggcaggtatc g" /listShort="yviA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3295721..3296410) /gene="degU" /locus_tag="BSU_35490" /old_locus_tag="BSU35490" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10908654, 11557812, 12471443, 12950930, 14563871, 15342569, 15598897, 17590234, 17827323, 21736639, 22677979, 24847778, 25288929, 25880922, 25887289, 27920766" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10908654, 11557812, 12471443, 12950930, 14563871, 15342569, 15598897, 17590234, 17827323, 21736639, 22677979, 24847778, 25288929, 25880922, 25887289, 27920766; Product type r : regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator" /protein_id="NP_391429.1" /db_xref="EnsemblGenomes-Gn:BSU35490" /db_xref="EnsemblGenomes-Tr:CAB15566" /db_xref="GOA:P13800" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG10393" /db_xref="UniProtKB/Swiss-Prot:P13800" /translation="MTKVNIVIIDDHQLFREGVKRILDFEPTFEVVAEGDDGDEAARI VEHYHPDVVIMDINMPNVNGVEATKQLVELYPESKVIILSIHDDENYVTHALKTGARG YLLKEMDADTLIEAVKVVAEGGSYLHPKVTHNLVNEFRRLATSGVSAHPQHEVYPEIR RPLHILTRRECEVLQMLADGKSNRGIGESLFISEKTVKNHVSNILQKMNVNDRTQAVV VAIKNGWVEMR*" /label="degU CDS" gene complement(3295721..3296410) /gene="degU" /locus_tag="BSU_35490" /old_locus_tag="BSU35490" /label="degU gene" downshifts complement(3295735) /Source="Nicolas_upshifts" /id="D1836" /incds=0 /nref=178 /ntot=235 /MaxReadThrough="5.12878" /MaxDrop="6.38336" /score="20.9249268" /energy="-12.8" /TU="U2781" /idTUdmin="U2779" /TUdmin="-946" /isTUend="FALSE" /label="downshifts" S_feature complement(3296411..3296492) /Source="Nicolas_S_feature" /locus_tag="new_3645297_3645378_c" /HighExp="M40t90, Lbtran, M0t90, LBGtran, G180, T3.0H, M40t45, C90, T3.30H, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1355" CDS complement(3296493..3297650) /gene="degS" /locus_tag="BSU_35500" /old_locus_tag="BSU35500" /EC_number="2.7.3.-" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:10908654, 11557812, 12471443, 12950930, 14563871, 15342569, 15598897, 17590234, 17827323, 21736639, 22677979, 24847778, 25288929, 25880922, 25887289, 27920766" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10908654, 11557812, 12471443, 12950930, 14563871, 15342569, 15598897, 17590234, 17827323, 21736639, 22677979, 24847778, 25288929, 25880922, 25887289, 27920766; Product type rc : receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [DegU]" /protein_id="NP_391430.1" /db_xref="EnsemblGenomes-Gn:BSU35500" /db_xref="EnsemblGenomes-Tr:CAB15567" /db_xref="GOA:P13799" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR008595" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR016381" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG10392" /db_xref="UniProtKB/Swiss-Prot:P13799" /translation="MNKTKMDSKVLDSILMKMLKTVDGSKDEVFQIGEQSRQQYEQLV EELKQIKQQVYEVIELGDKLEVQTRHARNRLSEVSRNFHRFSEEEIRNAYEKAHKLQV ELTMIQQREKQLRERRDDLERRLLGLQEIIERSESLVSQITVVLNYLNQDLREVGLLL ADAQAKQDFGLRIIEAQEEERKRVSREIHDGPAQMLANVMMRSELIERIFRDRGAEDG FQEIKNLRQNVRNALYEVRRIIYDLRPMALDDLGLIPTLRKYLYTTEEYNGKVKIHFQ CIGETEDQRLAPQFEVALFRLAQEAVSNALKHSESEEITVKVEITKDFVILMIKDNGK GFDLKEAKEKKNKSFGLLGMKERVDLLEGTMTIDSKIGLGTFIMIKVPLSL*" /label="degS CDS" gene complement(3296493..3297650) /gene="degS" /locus_tag="BSU_35500" /old_locus_tag="BSU35500" /label="degS gene" S_feature complement(3297651..3297778) /Source="Nicolas_S_feature" /locus_tag="new_3646537_3646664_c" /HighExp="T0.30H, Lbtran, M9-stat, T3.0H, T1.0H, HiOs, T1.30H, T2.30H, T3.30H, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1356" promotor_-35 3297698..3297701 /Source="Nicolas_upshift_promotors" /id="U2780" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.656343656343656" /psig="0.999000999001" /xcortree=2533 /SigmaFactorBS="ggcgttgtcatatatttttattataaatgtaATTGatctgca aattatgTCGAATTATAATGAAAGAATgcgtatattctagaaaaaaacatttttatat a" /listShort="S1357, yvyE, yvhJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3297716..3297735 /Source="Nicolas_upshift_promotors" /id="U2780" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.656343656343656" /psig="0.999000999001" /xcortree=2533 /SigmaFactorBS="ggcgttgtcatatatttttattataaatgtaATTGatctgca aattatgTCGAATTATAATGAAAGAATgcgtatattctagaaaaaaacatttttatat a" /listShort="S1357, yvyE, yvhJ" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3297727..3297813 /Source="Nicolas_S_feature" /locus_tag="new_3646613_3646699" /HighExp="UNK1, Cold, C30, Lbexp, MG 15, G135, G180, G150, Paraq, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1357" upshifts 3297727 /Source="Nicolas_upshifts" /id="U2780" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.656343656343656" /psig="0.999000999001" /xcortree=2533 /SigmaFactorBS="ggcgttgtcatatatttttattataaatgtaATTGatctgca aattatgTCGAATTATAATGAAAGAATgcgtatattctagaaaaaaacatttttatat a" /listShort="S1357, yvyE, yvhJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3297772..3297791) /Source="Nicolas_upshift_promotors" /id="U2781" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.928071928071928" /psig="0.998001998001998" /xcortree=2274 /SigmaFactorBS="agactgcctatacaaattcgtacagtcttTAGAATTTttgtg cgtatTTTGGTATCATAAAGAGTAGatagtatataaaaatgtttttttctagaatata c" /listShort="S1356, degS, S1355, degU, yviA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3297778) /Source="Nicolas_upshifts" /id="U2781" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.928071928071928" /psig="0.998001998001998" /xcortree=2274 /SigmaFactorBS="agactgcctatacaaattcgtacagtcttTAGAATTTttgtg cgtatTTTGGTATCATAAAGAGTAGatagtatataaaaatgtttttttctagaatata c" /listShort="S1356, degS, S1355, degU, yviA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3297795..3297803 /Source="Nicolas_upshift_promotors" /id="U2782" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1725 /SigmaFactorBS="acatttttatatactatctactctttatgataccaaaataCG CACAAAAattctaaagactgTACGAATTTgtataggcagtcttttatgcttagcagga g" /listShort="yvyE, yvhJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(3297802..3297809) /Source="Nicolas_upshift_promotors" /id="U2781" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.928071928071928" /psig="0.998001998001998" /xcortree=2274 /SigmaFactorBS="agactgcctatacaaattcgtacagtcttTAGAATTTttgtg cgtatTTTGGTATCATAAAGAGTAGatagtatataaaaatgtttttttctagaatata c" /listShort="S1356, degS, S1355, degU, yviA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3297815 /Source="Nicolas_upshifts" /id="U2782" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1725 /SigmaFactorBS="acatttttatatactatctactctttatgataccaaaataCG CACAAAAattctaaagactgTACGAATTTgtataggcagtcttttatgcttagcagga g" /listShort="yvyE, yvhJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3297817..3297825 /Source="Nicolas_upshift_promotors" /id="U2782" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=1725 /SigmaFactorBS="acatttttatatactatctactctttatgataccaaaataCG CACAAAAattctaaagactgTACGAATTTgtataggcagtcttttatgcttagcagga g" /listShort="yvyE, yvhJ" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3297867..3298520 /gene="yvyE" /locus_tag="BSU_35510" /old_locus_tag="BSU35510" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11116084, 15103642, 21239490, 22404850; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative translation regulator" /protein_id="NP_391431.1" /db_xref="EnsemblGenomes-Gn:BSU35510" /db_xref="EnsemblGenomes-Tr:CAB15568" /db_xref="InterPro:IPR001498" /db_xref="InterPro:IPR015269" /db_xref="InterPro:IPR015796" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR020569" /db_xref="InterPro:IPR023582" /db_xref="InterPro:IPR035647" /db_xref="InterPro:IPR036956" /db_xref="SubtiList:BG11052" /db_xref="UniProtKB/Swiss-Prot:P32437" /translation="MLHSYFTVKEAGEHEIVIEKSRFICHLSRVSTEQEAQEFIQKIK KQHWNATHNCSAYVIGENDHIQKANDDGEPSGTAGVPMLEVLKKRRLKDTCAVVTRYF GGIKLGAGGLIRAYGKSVSEGLNHIGVVERKLMRIMHTSADYTWLGKIENELRESQFL LKEIHYSENVEFETYVEEKETNAFSEWMTELTNGKSDIKEGELTYLEKAVNHIKETE* " /label="yvyE CDS" gene 3297867..3298520 /gene="yvyE" /locus_tag="BSU_35510" /old_locus_tag="BSU35510" /label="yvyE gene" S_feature complement(3298223..3298815) /Source="Nicolas_S_feature" /locus_tag="new_3647109_3647701_c" /HighExp="Etha, M9-stat, Gly, C30, B60, Salt, T0.30H, Sw, LoTm, S8" /AntisenseName="yvyE" /AntisenseCor="-0.139956338862644" /AntisenseRegPval="-1.7" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1358" CDS 3298520..3299695 /gene="tagV" /locus_tag="BSU_35520" /old_locus_tag="BSU35520" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:19099556, 29107701" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19099556, 29107701; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="teichoic acid-peptidoglycan tethering enzyme (LCP component) with transcription regulator domain" /protein_id="NP_391432.1" /db_xref="EnsemblGenomes-Gn:BSU35520" /db_xref="EnsemblGenomes-Tr:CAB15569" /db_xref="GOA:P96499" /db_xref="InterPro:IPR004474" /db_xref="PDB:3NXH" /db_xref="SubtiList:BG12449" /db_xref="UniProtKB/Swiss-Prot:P96499" /translation="MAERVRVRVRKKKKSKRRKILKRIMLLFALALLVVVGLGGYKLY KTINAADESYDALSRGNKSNLRNEVVDMKKKPFSILFMGIEDYATKGQKGRSDSLIVV TLDPKNKTMKMLSIPRDTRVQLAGDTTGSKTKINAAYSKGGKDETVETVENFLQIPID KYVTVDFDGFKDVINEVGGIDVDVPFDFDEKSDVDESKRIYFKKGEMHLNGEEALAYA RMRKQDKRGDFGRNDRQKQILNALIDRMSSASNIAKIDKIAEKASENVETNIRITEGL ALQQIYSGFTSKKIDTLSITGSDLYLGPNNTYYFEPDATNLEKVRKTLQEHLDYTPDT STGTSGTEDGTDSSSSSGSTGSTGTTTDGTTNGSSYSNDSSTSSNNSTTNSTTDSSY* " /label="tagV CDS" gene 3298520..3299695 /gene="tagV" /locus_tag="BSU_35520" /old_locus_tag="BSU35520" /label="tagV gene" promotor_-10 complement(3298811..3298829) /Source="Nicolas_upshift_promotors" /id="U2783" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=201 /SigmaFactorBS="gtgtgtcacgcggaatgctcagcattttcatGGTTTTAtttt tgggatccaGGGTAACAACAATAAGAGAgtctgatctccctttttgtcctttagtcgc g" /listShort="S1358" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3298820) /Source="Nicolas_upshifts" /id="U2783" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=201 /SigmaFactorBS="gtgtgtcacgcggaatgctcagcattttcatGGTTTTAtttt tgggatccaGGGTAACAACAATAAGAGAgtctgatctccctttttgtcctttagtcgc g" /listShort="S1358" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3298843..3298849) /Source="Nicolas_upshift_promotors" /id="U2783" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=201 /SigmaFactorBS="gtgtgtcacgcggaatgctcagcattttcatGGTTTTAtttt tgggatccaGGGTAACAACAATAAGAGAgtctgatctccctttttgtcctttagtcgc g" /listShort="S1358" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3299667 /Source="Nicolas_upshifts" /id="D1837" /incds=0 /nref=199 /ntot=276 /MaxReadThrough="2.38202" /MaxDrop="7.1642" /score="16.6000843" /energy="-18.6" /TU="NA" /idTUdmin="U2782" /TUdmin=4 /isTUend="TRUE" /label="downshifts" CDS complement(3299768..3300844) /gene="tagO" /locus_tag="BSU_35530" /old_locus_tag="BSU35530" /EC_number="2.7.8.33" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12101296, 12682299, 15849754, 16850406, 17012386, 18156271, 27312048" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12101296, 12682299, 15849754, 16850406, 17012386, 18156271, 27312048; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylglucosamine:undecaprenyl-P N-acetylglucosaminyl-1-P transferase" /protein_id="NP_391433.1" /db_xref="EnsemblGenomes-Gn:BSU35530" /db_xref="EnsemblGenomes-Tr:CAB15570" /db_xref="GOA:O34753" /db_xref="InterPro:IPR000715" /db_xref="InterPro:IPR018480" /db_xref="SubtiList:BG12684" /db_xref="UniProtKB/Swiss-Prot:O34753" /translation="MLDERMIRIVVAFIVSLLTVLIITPIVKRIAIKIGAVDQPSNRK VHDKIMPRMGGLAIFIGVVAGVLASGIYTETRMTAITVGAFIIIVLGILDDKYQLSAK VKFLIQLGVAIMIVSTGLKMDFFSVPFLTERFELGWMAYPLTVLWIVGITNAINLIDG LDGLAAGLSVIGLSTIAVMALSGGKVLILSLSLVVIASTLGFLFYNFHPAKIFMGDTG SLFLGYSISILSLLGLYKSVTLFSIVIPIIILGVPIFDTTFAIIRRILNKQPISAPDK SHIHHRLMAFGLSHRMSVLVIYLIGFIFSISAIVLKSATIWLSLFIIFILIIFMQIIA EVTGLVNEKFKPFTKFYKRLVKRN*" /label="tagO CDS" gene complement(3299768..3300844) /gene="tagO" /locus_tag="BSU_35530" /old_locus_tag="BSU35530" /label="tagO gene" downshifts complement(3299784) /Source="Nicolas_upshifts" /id="D1838" /incds=0 /nref=221 /ntot=280 /MaxReadThrough="1.7614" /MaxDrop="8.41647" /score="29.109706" /energy="-11.6" /TU="NA" /idTUdmin="U2785" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 3299830..3299839 /Source="Nicolas_upshift_promotors" /id="U2784" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1388 /SigmaFactorBS="tgtaaacggcttaaatttttcattcacgaGTCCTGTCACttc tgctatgattTGCATAAAAATAATCAAAATgaagataataaacaaagaaagccaaatt g" /listShort="S1359" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3299853..3299872 /Source="Nicolas_upshift_promotors" /id="U2784" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1388 /SigmaFactorBS="tgtaaacggcttaaatttttcattcacgaGTCCTGTCACttc tgctatgattTGCATAAAAATAATCAAAATgaagataataaacaaagaaagccaaatt g" /listShort="S1359" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3299861..3301094 /Source="Nicolas_S_feature" /locus_tag="new_3648747_3649980" /HighExp="S8, S6, S7, S5, BT, S4, B36, Pyr, S3, G/S" /AntisenseName="tagO" /AntisenseCor="-0.60515751332040901" /AntisenseRegPval="-27.5" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1359" upshifts 3299861 /Source="Nicolas_upshifts" /id="U2784" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1388 /SigmaFactorBS="tgtaaacggcttaaatttttcattcacgaGTCCTGTCACttc tgctatgattTGCATAAAAATAATCAAAATgaagataataaacaaagaaagccaaatt g" /listShort="S1359" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3300845..3300927) /Source="Nicolas_S_feature" /locus_tag="new_3649731_3649813_c" /HighExp="LPhT, Cold, LoTm, T0.30H, T3.0H, LBGstat, T1.30H, T1.0H, T2.30H, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.67123699999999997" /TUshortSig="SigA, Sig-" /TUshortPSig="1, 0.018" /TUlongSig="NA" /TUlongPSig="NA" /label="S1360" promotor_-10 complement(3300915..3300934) /Source="Nicolas_upshift_promotors" /id="U2785" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.856143856143856" /psig=1 /xcortree=2139 /SigmaFactorBS="cctataaattgggatgcgcgttttttgattatacgTGTTTCT ttttgatgaagCTTGTTATAATAACTAAGGAgaaggtataatggaaggaacggttctc t" /listShort="S1360, tagO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3300927) /Source="Nicolas_upshifts" /id="U2785" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.856143856143856" /psig=1 /xcortree=2139 /SigmaFactorBS="cctataaattgggatgcgcgttttttgattatacgTGTTTCT ttttgatgaagCTTGTTATAATAACTAAGGAgaaggtataatggaaggaacggttctc t" /listShort="S1360, tagO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3300946..3300952) /Source="Nicolas_upshift_promotors" /id="U2785" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.856143856143856" /psig=1 /xcortree=2139 /SigmaFactorBS="cctataaattgggatgcgcgttttttgattatacgTGTTTCT ttttgatgaagCTTGTTATAATAACTAAGGAgaaggtataatggaaggaacggttctc t" /listShort="S1360, tagO" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3300989..3302182) /gene="tuaH" /locus_tag="BSU_35540" /old_locus_tag="BSU35540" /EC_number="2.4.1.-" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 4975313, 10048024, 11994144, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase (teichuronic acid)" /protein_id="NP_391434.1" /db_xref="EnsemblGenomes-Gn:BSU35540" /db_xref="EnsemblGenomes-Tr:CAB15571" /db_xref="GOA:O32267" /db_xref="SubtiList:BG12695" /db_xref="UniProtKB/Swiss-Prot:O32267" /translation="METKEAIIHVIVATAEWGKDQLRYRRHRLAEFLAAQEETKEVIW VCPAPRAQGKEFQEVHSGIRQFAVKDLLQKKMFRFGRYTDVFYRHKLSPLLDELTPAS ANGERCCLWYTFPGFPLLSSLYSWDQVIYDCSDLWAAPISGRSNLLSEFRRKVIKSAE LRIIQRADSITCSSDYLHKEVDKKLTAGREKVHTVENGVEYELFSANKQAPDRSILQG REGIVLGFIGGIKPKLDFKMIKEAALQKPDWTFLWVGPDATNGDVSFQELLRLPNVIW TGPADPKEVPHYMELIDIGIMPYKQSPYNQAVFPLKLFEFLAAGKPVVGTNLPSTSKM QKPYVYEYVEGDHPIDFIAACEKVLGQNGDETYKEMRRNIARTQDWNCLFRQIMKYTG IQKHA*" /label="tuaH CDS" gene complement(3300989..3302182) /gene="tuaH" /locus_tag="BSU_35540" /old_locus_tag="BSU35540" /label="tuaH gene" downshifts complement(3301019) /Source="Nicolas_upshifts" /id="D1839" /incds=0 /nref=23 /ntot=141 /MaxReadThrough="7.20583" /MaxDrop="4.88676" /score="4.72365619" /energy="-10.8" /TU="U2786" /idTUdmin="U2785" /TUdmin="-1236" /isTUend="FALSE" /label="downshifts" CDS complement(3302211..3302969) /gene="tuaG" /locus_tag="BSU_35550" /old_locus_tag="BSU35550" /EC_number="2.4.1.-" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 4975313, 10048024, 11994144, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase (teichuronic acid)" /protein_id="NP_391435.1" /db_xref="EnsemblGenomes-Gn:BSU35550" /db_xref="EnsemblGenomes-Tr:CAB15572" /db_xref="GOA:O32268" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG12694" /db_xref="UniProtKB/Swiss-Prot:O32268" /translation="MTNWKPLVSVITPSYNARDYIEDTVHSVLDQSHPHWEMIIVDDC STDGTRDILQQYEKIDERIHVVYLEENSGAAVARNKALERAQGRYVAFLDSDDKWKKD KLEKQLEFMMERSCAFSFTGYSLMAQDGTPLDKFIHAPESLTYDDALKNTIIGCLTVM IDREQTGQIQMPNIRTRQDLATWLSLLKKGFTAYGMNECLAEYRLVNNSISSNKWKAA KKTWFVYREIERLHFMKATWCFVQYAKNAVKKRL*" /label="tuaG CDS" gene complement(3302211..3302969) /gene="tuaG" /locus_tag="BSU_35550" /old_locus_tag="BSU35550" /label="tuaG gene" CDS complement(3302993..3303673) /gene="tuaF" /locus_tag="BSU_35560" /old_locus_tag="BSU35560" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 4975313, 10048024, 11994144, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase involved in teichuronic acid synthesis" /protein_id="NP_391436.1" /db_xref="EnsemblGenomes-Gn:BSU35560" /db_xref="EnsemblGenomes-Tr:CAB15573" /db_xref="GOA:O32269" /db_xref="InterPro:IPR003856" /db_xref="SubtiList:BG12693" /db_xref="UniProtKB/Swiss-Prot:O32269" /translation="MNDILIRIARRIKKNIIWIIAVPIILGAAGYILPSQIADQKSYT AEDTLAVGSYDHPVYNSTEEIPLLLKSDSFLKEALPDEKDEDVAEIKEKLTINTESKS LLTLSYSDEDKDRTESVLNAISSTFLKNDQKLYAEREAVIRSSIDALEGESVSEDSKV DKERFLYELKNTQLNLKAASVTDSETVSETAGGGMSPKKKAVLGVMIGLTIAFMFVVI PEFFRESF*" /label="tuaF CDS" gene complement(3302993..3303673) /gene="tuaF" /locus_tag="BSU_35560" /old_locus_tag="BSU35560" /label="tuaF gene" CDS complement(3303702..3305168) /gene="tuaE" /locus_tag="BSU_35570" /old_locus_tag="BSU35570" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 4975313, 10048024, 11994144, 15849754, 16850406, 26284661; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="putative polymerase of teichuronic acid repeating units" /protein_id="NP_391437.1" /db_xref="EnsemblGenomes-Gn:BSU35570" /db_xref="EnsemblGenomes-Tr:CAB15574" /db_xref="GOA:O32270" /db_xref="InterPro:IPR007016" /db_xref="SubtiList:BG12692" /db_xref="UniProtKB/Swiss-Prot:O32270" /translation="MSIKRSAVHTLALLAAAIFGVVLLLGAIHKDIGFMQMAAVLAVL AIGLFLLTLATAFTTKERLFMAVIYILIACTFLNNAFFAIHLGFFSLFLYRLLLIAAG CLHIFGMVRNRTHIERWHGLQVKGILLFFAFWFIYGLVSLLWAKSVTVGLKYLALLAM GIFFIYLIVMYVQKMERLMIVYAIWLVMTVFLMIIGFYNHITHHHLASSTLYSGPEYK QHYPTSVFFNQNDFATFLSISFFFYITMMKNIKNGYIKAIGLVLSLCALYLIFATGSR ASLLGIFAGIAVYIFIVLPPVLKRMAIWLSAAGIALFAVLFASKIYSKFWELFLAPQT LHSFHDRLPSNVARANLLKNAWHFFLDSYGFGVGAGNVSYYLEHYAVYDTDNVAEVHN WLVEILANFGLFIMLGYLSVYAYLIWVLYKFYERKLENQSKLITEGLITAMVSFLVSS ISPSSVSNLFFHWVFMALVIAAVNVLRRSRQMPEPMYR*" /label="tuaE CDS" gene complement(3303702..3305168) /gene="tuaE" /locus_tag="BSU_35570" /old_locus_tag="BSU35570" /label="tuaE gene" S_feature complement(3305169..3305252) /Source="Nicolas_S_feature" /locus_tag="new_3654055_3654138_c" /HighExp="LPhT, S3, B60, S7, S4, S6, LBGstat, BI, S8, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.018" /TUlongSig="NA" /TUlongPSig="NA" /label="S1361" CDS complement(3305253..3306638) /gene="tuaD" /locus_tag="BSU_35580" /old_locus_tag="BSU35580" /EC_number="1.1.1.22" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10376820, 10913081, 12970183, 16000785, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10376820, 10913081, 12970183, 16000785, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-glucose 6-dehydrogenase (teichuronic acid)" /protein_id="NP_391438.1" /db_xref="EnsemblGenomes-Gn:BSU35580" /db_xref="EnsemblGenomes-Tr:CAB15575" /db_xref="GOA:O32271" /db_xref="InterPro:IPR001732" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR014026" /db_xref="InterPro:IPR014027" /db_xref="InterPro:IPR017476" /db_xref="InterPro:IPR021157" /db_xref="InterPro:IPR028357" /db_xref="InterPro:IPR036220" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12691" /db_xref="UniProtKB/Swiss-Prot:O32271" /translation="MKKIAVIGTGYVGLVSGTCFAEIGNKVVCCDIDESKIRSLKNGV IPIYEPGLADLVEKNVLDQRLTFTNDIPSAIRASDIIYIAVGTPMSKTGEADLTYVKA AAKTIGEHLNGYKVIVNKSTVPVGTGKLVQSIVQKASKGRYSFDVVSNPEFLREGSAI HDTMNMERAVIGSTSHKAAAIIEELHQPFHAPVIKTNLESAEMIKYAANAFLATKISF INDIANICERVGADVSKVADGVGLDSRIGRKFLKAGIGFGGSCFPKDTTALLQIAKSA GYPFKLIEAVIETNEKQRVHIVDKLLTVMGSVKGRTISVLGLAFKPNTNDVRSAPALD IIPMLQQLGAHVKAYDPIAIPEASAILGEQVEYYTDVYAAMEDTDACLILTDWPEVKE MELVKVKTLLKQPVIIDGRNLFSLEEMQAAGYIYHSIGRPAVRGTEPSDKYFPGLPLE ELAKDLGSVNL*" /label="tuaD CDS" gene complement(3305253..3306638) /gene="tuaD" /locus_tag="BSU_35580" /old_locus_tag="BSU35580" /label="tuaD gene" CDS complement(3306700..3307869) /gene="tuaC" /locus_tag="BSU_35590" /old_locus_tag="BSU35590" /EC_number="2.4.1.-" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 4975313, 10048024, 11994144, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase (teichuronic acid)" /protein_id="NP_391439.1" /db_xref="EnsemblGenomes-Gn:BSU35590" /db_xref="EnsemblGenomes-Tr:CAB15576" /db_xref="GOA:O32272" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR028098" /db_xref="SubtiList:BG12690" /db_xref="UniProtKB/Swiss-Prot:O32272" /translation="MKILWITSVYPSSMKPGEGVFHETQVQELQKLGLDITVICPRPF HSAPVRMLKKTYRKKDVRPEYEIRKGIPVYRPFYRAVPGQLKWAQPHRRIASAVLKTM KQRDLYPDLIHAHFAMPSGGAAAVVSESAQIPYVLTLHGSDVNVYPHYSKGAFKAFKR AVGSASVVLAVSHKLQEEAKKLSGFDSSVLPIGIQLSRFQGNEETKEEIRKRLGLPLD QRLAVYVGRLVREKGIFELSEAIESLQDSPKAVFVGDGPAKSTLTQKGHIVTGQVPNH QVRDYLLAADLFVLPSYSEGMPTVVIEALALRVPVICTDVGGVSSLFGKHQHLLIKPK SAQALAEAITRYEHEQIWKPEVADDLYETVQAQFDAGKNAKALHHQYQTVTKTSV*" /label="tuaC CDS" gene complement(3306700..3307869) /gene="tuaC" /locus_tag="BSU_35590" /old_locus_tag="BSU35590" /label="tuaC gene" CDS complement(3307866..3309317) /gene="tuaB" /locus_tag="BSU_35600" /old_locus_tag="BSU35600" /function="16.8: Protect" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10048024, 11994144, 15849754, 16850406, 22720735, 26284661; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative exporter involved in biosynthesis of teichuronic acid" /protein_id="NP_391440.1" /db_xref="EnsemblGenomes-Gn:BSU35600" /db_xref="EnsemblGenomes-Tr:CAB15577" /db_xref="GOA:O32273" /db_xref="InterPro:IPR002797" /db_xref="InterPro:IPR029303" /db_xref="SubtiList:BG12689" /db_xref="UniProtKB/Swiss-Prot:O32273" /translation="MPSITKQIMSGAKWTSISTMCITIIQIVQFALLGNMMTLTEFGL VGMITTVTVFAQIVLDMGFGAALIQRDDATERQLSTLYWLNIMTGVLLFVLLYVSSPV IAGFYQREELVFLVRILAIMFLIAPIGQQYQYMLQKQLHFNTLSKIEIFSNVLSFGYL AIAVFMMDAILAYVISQVLLQSSKGILYWAVYRKKWHPAFVFDLRGMKDFFSFGAFQL SSRLVNRLGANIDMILIGRFIGAEALGIYNLAYQIVTIPVLKINPIVTRVAFPIFAKN KYENSVIREGFLNMTKMLALVSFPLLIGLVSVSDAFITAVFGEKWLAAVPILNVLAIV GILRVLMNPNGSVLLAKGRADLAFYWDSGVLLLYGLSLFAAVQTGSLLTVAWVYAIIS VVNFLIGRWLLAYVIKLNLSAYFQSIMKPFLITAAMGIIAFGVSLSTEHFSMQAEMRL AISVAAGALCYLFLLVKAYPQTKSKLLRKGRLS*" /label="tuaB CDS" gene complement(3307866..3309317) /gene="tuaB" /locus_tag="BSU_35600" /old_locus_tag="BSU35600" /label="tuaB gene" CDS complement(3309373..3309522) /gene="tuaAc" /locus_tag="BSU_35609" /old_locus_tag="BSU35609" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId: 7704262, 26284661; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative undecaprenyl-phosphate N-acetylgalactosaminyl-1-phosphate transferase; C-terminal part of TuaA" /db_xref="SubtiList:BG12688" /translation="WAQVNGGYDMTPKEKLIFDLYYIRNLTFTLELKIMLKTCKVVWT GDGAR*" /label="tuaAc CDS" gene complement(3309373..3309522) /gene="tuaAc" /locus_tag="BSU_35609" /old_locus_tag="BSU35609" /pseudo /label="tuaAc gene" CDS complement(3309467..3310006) /gene="tuaAn" /locus_tag="BSU_35610" /old_locus_tag="BSU35610" /EC_number="2.7.8.-" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 10048024, 11994144, 26284661; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative undecaprenyl-phosphate N-acetylgalactosaminyl-1-phosphate transferase; N-terminal part of TuaA" /translation="MSAEKSMNVSREFSVQQIHSFTLSEKTARYLAIKRVMDIWFALI GLAIALPMIAVFSILICLETPGPAIYTQERVGKGGKPFKLYKLRSMKIDAEKSGAVWA QKQDPRVTRIGAFIRRTRIDELPQLFNVLKGDMSMIGPRPERPVFTEKFQNEIPGFTQ RLGSGERRLRYDAEGKADI*" /label="tuaAn CDS" gene complement(3309467..3310006) /gene="tuaAn" /locus_tag="BSU_35610" /old_locus_tag="BSU35610" /pseudo /label="tuaAn gene" misc_feature complement(3310062..3310079) /Source="Nicolas_upshift_promotors" /id="U2786" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.977022977022977" /psig="0.017982017982018" /xcortree=12 /SigmaFactorBS="cagaaaaaacacgtaattcacacttcttaacataccatttac atccaATTAACATCCGTCTGCTAaactgactggcataggtcatcataacatcccaaac a" /listShort="tuaA, tuaA, tuaB, tuaC, tuaD, S1361, tuaE, tuaF, tuaG, tuaH, S1360, tagO" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3310066) /Source="Nicolas_upshifts" /id="U2786" /multdbtbs="SigA" /comp="M6" /sig="Sig-" /pcomp="0.977022977022977" /psig="0.017982017982018" /xcortree=12 /SigmaFactorBS="cagaaaaaacacgtaattcacacttcttaacataccatttac atccaATTAACATCCGTCTGCTAaactgactggcataggtcatcataacatcccaaac a" /listShort="tuaA, tuaA, tuaB, tuaC, tuaD, S1361, tuaE, tuaF, tuaG, tuaH, S1360, tagO" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3310233..3311723) /gene="lytC" /locus_tag="BSU_35620" /old_locus_tag="BSU35620" /EC_number="3.5.1.28" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:1357079, 9537764, 14594841, 17298895, 19542270, 22469514" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1357079, 9537764, 14594841, 17298895, 19542270, 22469514; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="N-acetylmuramoyl-L-alanine amidase (major autolysin)" /protein_id="NP_391442.1" /db_xref="EnsemblGenomes-Gn:BSU35620" /db_xref="EnsemblGenomes-Tr:CAB15579" /db_xref="GOA:Q02114" /db_xref="InterPro:IPR002508" /db_xref="InterPro:IPR007253" /db_xref="SubtiList:BG10407" /db_xref="UniProtKB/Swiss-Prot:Q02114" /translation="MRSYIKVLTMCFLGLILFVPTALADNSVKRVGGSNRYGTAVQIS KQMYSTASTAVIVGGSSYADAISAAPLAYQKNAPLLYTNSDKLSYETKTRLKEMQTKN VIIVGGTPAVSSNTANQIKSLGISIKRIAGSNRYDTAARVAKAMGATSKAVILNGFLY ADAPAVIPYAAKNGYPILFTNKTSINSATTSVIKDKGISSTVVVGGTGSISNTVYNKL PSPTRISGSNRYELAANIVQKLNLSTSTVYVSNGFSYPDSIAGATLAAKKKQSLILTN GENLSTGARKIIGSKNMSNFMIIGNTPAVSTKVANQLKNPVVGETIFIDPGHGDQDSG AIGNGLLEKEVNLDIAKRVNTKLNASGALPVLSRSNDTFYSLQERVNKAASAQADLFL SIHANANDSSSPNGSETYYDTTYQAANSKRLAEQIQPKLAANLGTRDRGVKTAAFYVI KYSKMPSVLVETAFITNASDASKLKQAVYKDKAAQAIHDGTVSYYR*" /label="lytC CDS" gene complement(3310233..3311723) /gene="lytC" /locus_tag="BSU_35620" /old_locus_tag="BSU35620" /label="lytC gene" downshifts complement(3310255) /Source="Nicolas_upshifts" /id="D1840" /incds=0 /nref=145 /ntot=213 /MaxReadThrough="3.26689" /MaxDrop="6.50948" /score="13.9455176" /energy="-13.3" /TU="NA" /idTUdmin="U2788" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3311762..3313879) /gene="lytB" /locus_tag="BSU_35630" /old_locus_tag="BSU35630" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /function="16.13: Shape" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1357079, 16306698, 17269748" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1357079, 16306698, 17269748; Product type r: regulator" /codon_start=1 /transl_table=11 /product="modifier of major autolysin amidase LytC" /protein_id="NP_391443.1" /db_xref="EnsemblGenomes-Gn:BSU35630" /db_xref="EnsemblGenomes-Tr:CAB15580" /db_xref="GOA:Q02113" /db_xref="InterPro:IPR007253" /db_xref="InterPro:IPR013486" /db_xref="InterPro:IPR013693" /db_xref="SubtiList:BG10406" /db_xref="UniProtKB/Swiss-Prot:Q02113" /translation="MKSCKQLIVCSLAAILLLIPSVSFAADSNISVKLLNYIGNKSSI SLSPTGFYKVTGDNVAVTDRFAGASRYETATLASNSQWKNPNTVILVNRDIFIDALPV IPLAKKLNAPVLFTQPDTLTKTTERQIAKFNPDNILIIGGARSISKDVENKLKSYGAV KRISGKNRYVLSENIAKQMGSYDKAIVVTGRVFQDALAIAPYAAAHGYPILLTEKDKL PDYDLPKQVIIIGSSFSVSDSVENQIKKTSTVQRIPGSTRYELTANIIKQLKLKADKV VMTNGTKYADVLIGASLASKKNSQILFVKQDSVPAAAKSITKDKATYAYDFIGSTSSI SAEVENSLADEFYLADGGTYNLKINSGKLNLENIKTYGNSLRIKPENYSTSNRISLDG KQYLGTVNFSIESTKYIRPVNENIPFEDYLKGVIPNEMPASWSLEALKAQTVAARTYS ITKTGTTVPDTTAFQVYGGYSWNSNTNKAVEQTKGKVLKYNGSLITAAYSSSNGGYTE ASNEVWSSSVPYLIAKKDTKDPQIGWTLTLSKQQLDTKSLDLTKPSSWWSSATETDSA RLSGVKNWILKNKETSADSVKIASIDDLSFSGTTQGQRAKTASMKVKYFVKSSTGSYN LSKITTISVPTSELRTMIGATVFKSTYVTVKKDTSKYTISGKGYGHGIGMSQYGAKAR AEAGDSYSSILKFYYPGTTLTSY*" /label="lytB CDS" gene complement(3311762..3313879) /gene="lytB" /locus_tag="BSU_35630" /old_locus_tag="BSU35630" /label="lytB gene" CDS complement(3313903..3314211) /gene="lytA" /locus_tag="BSU_35640" /old_locus_tag="BSU35640" /function="16.13: Shape" /function="16.11: Scavenge (Catabolism)" /function="16.1: Circulate" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:1357079, 10974124, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1357079, 10974124, 22720735; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="membrane bound lipoprotein" /protein_id="NP_391444.1" /db_xref="EnsemblGenomes-Gn:BSU35640" /db_xref="EnsemblGenomes-Tr:CAB15581" /db_xref="GOA:Q02112" /db_xref="SubtiList:BG10405" /db_xref="UniProtKB/Swiss-Prot:Q02112" /translation="MKKFIALLFFILLLSGCGVNSQKSQGEDVSPDSNIETKEGTYVG LADTHTIEVTVDNEPVSLDITEESTSDLDKFNSGDKVTITYEKNDEGQLLLKDIERAN *" /label="lytA CDS" gene complement(3313903..3314211) /gene="lytA" /locus_tag="BSU_35640" /old_locus_tag="BSU35640" /label="lytA gene" downshifts 3314117 /Source="Nicolas_upshifts" /id="D1841" /incds=1 /nref=1 /ntot=45 /MaxReadThrough="1.03108" /MaxDrop="2.46089" /score="-4.93783022" /energy="-8" /TU="NA" /idTUdmin="U2787" /TUdmin="-198" /isTUend="FALSE" /label="downshifts" promotor_-35 3314207..3314211 /Source="Nicolas_upshift_promotors" /id="U2787" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.998001998001998" /psig=0 /xcortree=300 /SigmaFactorBS="cgaaagaagcaatataaagaacagtaaagcaataaattttTT CATttttttcaCCTCATTATATTTTAtcgtcaacctattttatattttaaagaaaaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3314220..3314234 /Source="Nicolas_upshift_promotors" /id="U2787" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.998001998001998" /psig=0 /xcortree=300 /SigmaFactorBS="cgaaagaagcaatataaagaacagtaaagcaataaattttTT CATttttttcaCCTCATTATATTTTAtcgtcaacctattttatattttaaagaaaaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(3314221..3314239) /Source="Nicolas_upshift_promotors" /id="U2788" /multdbtbs="SigA,SigD" /comp="M10" /sig="SigD" /pcomp="0.925074925074925" /psig="0.925074925074925" /xcortree=2795 /SigmaFactorBS="gaaatcctaaaatagtcgttttttataaaaaaaagtttcatt gtttcttaatttttCTTTAAAAtataaaataggttGACGATAAAATATAATGAGgtga a" /listShort="lytA, lytB, lytC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3314227 /Source="Nicolas_upshifts" /id="U2787" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.998001998001998" /psig=0 /xcortree=300 /SigmaFactorBS="cgaaagaagcaatataaagaacagtaaagcaataaattttTT CATttttttcaCCTCATTATATTTTAtcgtcaacctattttatattttaaagaaaaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3314253..3314260) /Source="Nicolas_upshift_promotors" /id="U2788" /multdbtbs="SigA,SigD" /comp="M10" /sig="SigD" /pcomp="0.925074925074925" /psig="0.925074925074925" /xcortree=2795 /SigmaFactorBS="gaaatcctaaaatagtcgttttttataaaaaaaagtttcatt gtttcttaatttttCTTTAAAAtataaaataggttGACGATAAAATATAATGAGgtga a" /listShort="lytA, lytB, lytC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3314256) /Source="Nicolas_upshifts" /id="U2788" /multdbtbs="SigA,SigD" /comp="M10" /sig="SigD" /pcomp="0.925074925074925" /psig="0.925074925074925" /xcortree=2795 /SigmaFactorBS="gaaatcctaaaatagtcgttttttataaaaaaaagtttcatt gtttcttaatttttCTTTAAAAtataaaataggttGACGATAAAATATAATGAGgtga a" /listShort="lytA, lytB, lytC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3314277..3314285 /Source="Nicolas_upshift_promotors" /id="U2789" /multdbtbs="SigX" /comp="M9" /sig="SigWXY" /pcomp="0.584415584415584" /psig="0.584415584415584" /xcortree=2152 /SigmaFactorBS="aaagaaaaattaagaaacaaTGAAACTTTtttttataaaaaa CGACTATTTTAGGAtttcattcttgtattaaatagagttgtatttattggaaatttaa c" /listShort="lytR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3314299..3314312 /Source="Nicolas_upshift_promotors" /id="U2789" /multdbtbs="SigX" /comp="M9" /sig="SigWXY" /pcomp="0.584415584415584" /psig="0.584415584415584" /xcortree=2152 /SigmaFactorBS="aaagaaaaattaagaaacaaTGAAACTTTtttttataaaaaa CGACTATTTTAGGAtttcattcttgtattaaatagagttgtatttattggaaatttaa c" /listShort="lytR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3314317 /Source="Nicolas_upshifts" /id="U2789" /multdbtbs="SigX" /comp="M9" /sig="SigWXY" /pcomp="0.584415584415584" /psig="0.584415584415584" /xcortree=2152 /SigmaFactorBS="aaagaaaaattaagaaacaaTGAAACTTTtttttataaaaaa CGACTATTTTAGGAtttcattcttgtattaaatagagttgtatttattggaaatttaa c" /listShort="lytR" /GFF_Attribute="listLong" /label="upshifts" CDS 3314395..3315315 /gene="tagU" /locus_tag="BSU_35650" /old_locus_tag="BSU35650" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1357079, 9636707, 12034833, 19099556, 28197687, 29107701" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1357079, 9636707, 12034833, 19099556, 28197687, 29107701; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="teichoic acid-peptidoglycan tethering enzyme (LCP component) with transcription regulator domain of major autolysin expression" /protein_id="NP_391445.1" /db_xref="EnsemblGenomes-Gn:BSU35650" /db_xref="EnsemblGenomes-Tr:CAB15582" /db_xref="GOA:Q02115" /db_xref="InterPro:IPR004474" /db_xref="InterPro:IPR023734" /db_xref="SubtiList:BG10404" /db_xref="UniProtKB/Swiss-Prot:Q02115" /translation="MRNERRKKKKTLLLTILTIIGLLVLGTGGYAYYLWHKAASTVAS IHESIDKSKKRDKEVSINKKDPFSVLIMGVDERDGDKGRADTLIYMTVNPKTNTTDMV SIPRDTYTKIIGKGTMDKINHSYAFGGTQMTVDTVENFLDVPVDYFVKVNMESFRDVV DTLGGITVNSTFAFSYDGYSFGKGEITLNGKEALAYTRMRKEDPRGDFGRQDRQRQVI QGIINKGANISSITKFGDMFKVVENNVKTNLTFDNMWDIQSDYKGARKHIKQHELKGT GTKINGIYYYQADESALSDITKELKESLEK*" /label="tagU CDS" gene 3314395..3315315 /gene="tagU" /locus_tag="BSU_35650" /old_locus_tag="BSU35650" /label="tagU gene" downshifts 3315305 /Source="Nicolas_upshifts" /id="D1842" /incds=0 /nref=224 /ntot=261 /MaxReadThrough="0.434639999999999" /MaxDrop="6.11301" /score="-4.93783022" /energy="-8" /TU="NA" /idTUdmin="U2789" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3315355..3316497) /gene="mnaA" /locus_tag="BSU_35660" /old_locus_tag="BSU35660" /EC_number="5.1.3.14" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12107153, 16952950" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12107153, 16952950; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylmannosamine 2-epimerase" /protein_id="NP_391446.1" /db_xref="EnsemblGenomes-Gn:BSU35660" /db_xref="EnsemblGenomes-Tr:CAB15583" /db_xref="GOA:P39131" /db_xref="InterPro:IPR003331" /db_xref="InterPro:IPR029767" /db_xref="PDB:1O6C" /db_xref="PDB:4FKZ" /db_xref="SubtiList:BG10403" /db_xref="UniProtKB/Swiss-Prot:P39131" /translation="MKKLKVMTVFGTRPEAIKMAPLVLELKKYPEIDSYVTVTAQHRQ MLDQVLDAFHIKPDFDLNIMKERQTLAEITSNALVRLDELFKDIKPDIVLVHGDTTTT FAGSLAAFYHQIAVGHVEAGLRTGNKYSPFPEELNRQMTGAIADLHFAPTGQAKDNLL KENKKADSIFVTGNTAIDALNTTVRDGYSHPVLDQVGEDKMILLTAHRRENLGEPMEN MFKAIRRIVGEFEDVQVVYPVHLNPVVREAAHKHFGDSDRVHLIEPLEVIDFHNFAAK SHFILTDSGGVQEEAPSLGKPVLVLRDTTERPEGVEAGTLKLAGTDEENIYQLAKQLL TDPDEYKKMSQASNPYGDGEASRRIVEELLFHYGYRKEQPDSFTGK*" /label="mnaA CDS" gene complement(3315355..3316497) /gene="mnaA" /locus_tag="BSU_35660" /old_locus_tag="BSU35660" /label="mnaA gene" downshifts complement(3315379) /Source="Nicolas_upshifts" /id="D1843" /incds=0 /nref=126 /ntot=236 /MaxReadThrough="0.41249" /MaxDrop="5.56107" /score="7.64930656" /energy="-11" /TU="NA" /idTUdmin="U2790" /TUdmin="-20" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3316536..3316555) /Source="Nicolas_upshift_promotors" /id="U2790" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=1891 /SigmaFactorBS="aaaacttatatcattttatttgaatcaagaatgaaatGATTt aaaatgatgcattTTCATGTAGAATATGTAGTAtgaatttatttactatagcagaaaa c" /listShort="mnaA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3316550) /Source="Nicolas_upshifts" /id="U2790" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=1891 /SigmaFactorBS="aaaacttatatcattttatttgaatcaagaatgaaatGATTt aaaatgatgcattTTCATGTAGAATATGTAGTAtgaatttatttactatagcagaaaa c" /listShort="mnaA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3316570..3316573) /Source="Nicolas_upshift_promotors" /id="U2790" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.984015984015984" /psig=1 /xcortree=1891 /SigmaFactorBS="aaaacttatatcattttatttgaatcaagaatgaaatGATTt aaaatgatgcattTTCATGTAGAATATGTAGTAtgaatttatttactatagcagaaaa c" /listShort="mnaA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3316626..3316630 /Source="Nicolas_upshift_promotors" /id="U2791" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.494505494505495" /psig="0.998001998001998" /xcortree=96 /SigmaFactorBS="tcaaataaaatgatataagttttaatattaaggataaaGCTT GtttaaaaatggtttaTCCGATATCATAAAAATGTGtaaaaacatattgaaaagggta a" /listShort="S1362, gtaB, S1363" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3316646..3316665 /Source="Nicolas_upshift_promotors" /id="U2791" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.494505494505495" /psig="0.998001998001998" /xcortree=96 /SigmaFactorBS="tcaaataaaatgatataagttttaatattaaggataaaGCTT GtttaaaaatggtttaTCCGATATCATAAAAATGTGtaaaaacatattgaaaagggta a" /listShort="S1362, gtaB, S1363" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3316647..3316742 /Source="Nicolas_S_feature" /locus_tag="new_3665533_3665628" /HighExp="C90, dia5, Salt, Lbexp, T1.0H, MG 5, GM 90, MG 45, LoTm, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1362" upshifts 3316648 /Source="Nicolas_upshifts" /id="U2791" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.494505494505495" /psig="0.998001998001998" /xcortree=96 /SigmaFactorBS="tcaaataaaatgatataagttttaatattaaggataaaGCTT GtttaaaaatggtttaTCCGATATCATAAAAATGTGtaaaaacatattgaaaagggta a" /listShort="S1362, gtaB, S1363" /GFF_Attribute="listLong" /label="upshifts" CDS 3316743..3317621 /gene="gtaB" /locus_tag="BSU_35670" /old_locus_tag="BSU35670" /EC_number="2.7.7.9" /function="16.8: Protect" /function="16.13: Shape" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:2846750, 8126437, 8320212, 9658024, 17662947, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2846750, 8126437, 8320212, 9658024, 17662947, 26735940; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="UTP-glucose-1-phosphate uridylyltransferase" /protein_id="NP_391447.1" /db_xref="EnsemblGenomes-Gn:BSU35670" /db_xref="EnsemblGenomes-Tr:CAB15584" /db_xref="GOA:Q05852" /db_xref="InterPro:IPR005771" /db_xref="InterPro:IPR005835" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG10402" /db_xref="UniProtKB/Swiss-Prot:Q05852" /translation="MKKVRKAIIPAAGLGTRFLPATKAMPKEMLPIVDKPTIQYIIEE AVEAGIEDIIIVTGKSKRAIEDHFDYSPELERNLEEKGKTELLEKVKKASNLADIHYI RQKEPKGLGHAVWCARNFIGDEPFAVLLGDDIVQAETPGLRQLMDEYEKTLSSIIGVQ QVPEEETHRYGIIDPLTSEGRRYQVKNFVEKPPKGTAPSNLAILGRYVFTPEIFMYLE EQQVGAGGEIQLTDAIQKLNEIQRVFAYDFEGKRYDVGEKLGFITTTLEFAMQDKELR DQLVPFMEGLLNKEEI*" /label="gtaB CDS" gene 3316743..3317621 /gene="gtaB" /locus_tag="BSU_35670" /old_locus_tag="BSU35670" /label="gtaB gene" S_feature 3317622..3318713 /Source="Nicolas_S_feature" /locus_tag="new_3666508_3667599" /HighExp="Etha, Gly, C30, M9-stat, B60, T1.30H, B36, T1.0H, M40t90, T0.30H" /AntisenseName="yvzH" /AntisenseCor="-0.24043295548020899" /AntisenseRegPval="-4.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1363" S_feature complement(3317691..3318046) /Source="Nicolas_S_feature" /locus_tag="new_3666577_3666932_c" /HighExp="C30, LPh, HPh, Gly, G135, HiOs, aero, GM 25, MG 25, GM-0.1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.74940200000000001" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigD" /TUlongPSig="0.996" /label="S1364" CDS 3317955..3318173 /locus_tag="BSU_35678" /old_locus_tag="BSU35678" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId: 7704262" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514004.1" /translation="MATILIPLTTLLDLSRIVGLIENHGIKPASIQTIKGTSPIPVMT SLLLRIPNTNQYAIIRIRGFKTCHNTPK*" /label="hypothetical protein CDS" gene 3317955..3318173 /locus_tag="BSU_35678" /old_locus_tag="BSU35678" /label="gene" CDS complement(3318047..3318130) /gene="yvzH" /locus_tag="BSU_35679" /old_locus_tag="BSU35679" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId: 7704262; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative teichoic acid translocation permease protein tagG (fragment)" /db_xref="PSEUDO:CAX52700.1" /translation="MMAYWFVFGMRNSKLVITGIGEVPFIV*" /label="yvzH CDS" gene complement(3318047..3318130) /gene="yvzH" /locus_tag="BSU_35679" /old_locus_tag="BSU35679" /pseudo /label="yvzH gene" S_feature complement(3318131..3318322) /Source="Nicolas_S_feature" /locus_tag="new_3667017_3667208_c" /HighExp="HPh, LPh, C30, Gly, S0, HiOs, aero, G135, Mal, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD" /TUshortPSig="1, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1365" CDS complement(3318323..3321025) /gene="ggaB" /locus_tag="BSU_35680" /old_locus_tag="BSU35680" /function="16.8: Protect" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:16735734" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16735734; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="poly(glucosyl N-acetylgalactosamine 1-phosphate)glucosyltransferase" /protein_id="NP_391448.1" /db_xref="EnsemblGenomes-Gn:BSU35680" /db_xref="EnsemblGenomes-Tr:CAB15585" /db_xref="GOA:P46918" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR007554" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG11192" /db_xref="UniProtKB/Swiss-Prot:P46918" /translation="MNEKSFNYDFSVIMPIYNVELYLTEAIESIINQTIGFENIQLIL VNDDSPDKSEIICKEYAQKYPNNIVYAKKQNGGVSSARNYGLKYAEGRYIQFLDPDDL VSEGTFENVLNFFDEHKNEIDIVAIPIFFAEGRTGEHNLNNKFSSTRILDVEKEPHHI LTHCCSTFIKKDALKNIRFDENCKIGEDAKLVNLIISQKKKYGLVKEAKYHYRVREDG SSAMQTAKANKNWFNHSLITFSKNLIDIIKNHEQKIPLFLQYMVMHDLKWKLLIKDIS ETPLDENEYSEFLTLIREVLSYIDDDVIIETKSVSHFYLYHALKIKHGENYSRYVYER ETEQDYYLYREGKIVSKLSDQTLTIEILEENEDSIHIEGFWSSLFNSKGFKFYAKIGE TKIKAKNIKRQHNDYISLGEVIKKYPGFSIDIPKGHLADNHHIEFFITKGKKRKLTKL RFFKYSGLSNDLYNTYVAKKDYIFYYNYKKLMFKKNNFKNRFIKEFRFLKSLHKSGEK SKKRKSAIKKALMARMVHHVFTIFNRKPVWLFIDRQDKADDNAEHLFKYAINKNDGVK KYFIIKKDSKDYDRIKKYGKVIPYRSFRHKILTLSSSKVISTHADIWVVNPFFNMEIY FRDLFNFEFIFLQHGITMADHSEWLNKYNKNIKLLVTSAKPEYRSIVKGNYNYKKENI LLGGFPRYDNLKKSEGEKQLLIMPTWRKDIVLPKDQAKGVRPYNPKFKDSEYFSRYNA LINDERLIEFAKKNNYKITFFPHPDIQQQIVDFEKHDYVEFADYNSSYQMLFNSSNIM ITDFSSVAFDFAYEKKPVIYYQYEKSYHFKLDYYDYKKMGFGDVLENHNSLVDKVIYY MKNNSRMEDKYRKRVDNFFAYTDKNNRNRIYNAILELDNNKVAK*" /label="ggaB CDS" gene complement(3318323..3321025) /gene="ggaB" /locus_tag="BSU_35680" /old_locus_tag="BSU35680" /label="ggaB gene" S_feature complement(3321026..3321148) /Source="Nicolas_S_feature" /locus_tag="new_3669912_3670034_c" /HighExp="BMM, HiOs, MG 15, C30, SMM, GM 90, HPh, MG 150, MG 25, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD" /TUshortPSig="1, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1366" promotor_-35 3321047..3321053 /Source="Nicolas_upshift_promotors" /id="U2792" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=207 /SigmaFactorBS="ttttttcgttcataaaagattactcctaacataaTGTTTATa tgaataagaattcGGGTAAATAAAATTAAGAAacaagagagtactaatttttgcaaaa c" /listShort="S1367, S1370, yvzE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3321068..3321086 /Source="Nicolas_upshift_promotors" /id="U2792" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=207 /SigmaFactorBS="ttttttcgttcataaaagattactcctaacataaTGTTTATa tgaataagaattcGGGTAAATAAAATTAAGAAacaagagagtactaatttttgcaaaa c" /listShort="S1367, S1370, yvzE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3321073..3323905 /Source="Nicolas_S_feature" /locus_tag="new_3669959_3672791" /HighExp="Sw, LoTm, M9-stat, Salt, B60, T0.30H, Gly, T1.0H, B36, BI" /AntisenseName="ggaA" /AntisenseCor="-0.503651102561819" /AntisenseRegPval="-18" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1367" upshifts 3321073 /Source="Nicolas_upshifts" /id="U2792" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=207 /SigmaFactorBS="ttttttcgttcataaaagattactcctaacataaTGTTTATa tgaataagaattcGGGTAAATAAAATTAAGAAacaagagagtactaatttttgcaaaa c" /listShort="S1367, S1370, yvzE" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3321149..3322489) /gene="ggaA" /locus_tag="BSU_35690" /old_locus_tag="BSU35690" /function="16.5: Explore" /function="16.8: Protect" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16735734, 7704262; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="poly(glucosyl N-acetylgalactosamine 1-phosphate)glucosyltransferase (missing signal peptide)" /db_xref="EnsemblGenomes-Gn:BSU35690" /db_xref="EnsemblGenomes-Tr:CAB15586" /db_xref="GOA:P46917" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="PSEUDO:CAB15586.1" /db_xref="SubtiList:BG11367" /db_xref="UniProtKB/Swiss-Prot:P46917" /translation="MFSIIIPIYNSENYLRYSIESVLNQSIGFKENIELILIDDGSVD SSPQICESFKNLYPNNIKIMKIENSGPSAARNCGLSNVSERSKFIGFLDSDDAFSQNA LQSVYDFFCDSEHVNIAVLPVYYTGEKEGGHKLNNRFEKGTRVINILNDYKAIHFYIG GTFYRRHTLTSTVLFDESIKFWEDAIFFNQLLLKEKRYGAVAEGKYFYRKRKEQDSLV DRSWFNKKRYTYLLNECYMTLLMDSFNKYDIVLPYLQFLIVYHIKLFLYPNYRDVYKS VLDQQEQRVFVDDFIKVLKFIDPQFIKEQDMPMYYKEFMFHLLKENTEALENIKKERV LHSSCTVTSAKIKGLRLELTGHFINQYYEMKENDRIYIKYFKRLKKCKRKELKKTIEV WGYKLRDFRYAGFVVEIPIWAFAFDFVLKTPNDSLELNHVNIFKSLLTRVFKKR*" /label="ggaA CDS" gene complement(3321149..3322489) /gene="ggaA" /locus_tag="BSU_35690" /old_locus_tag="BSU35690" /pseudo /label="ggaA gene" CDS complement(3322530..3322736) /gene="yvzI" /locus_tag="BSU_35698" /old_locus_tag="BSU35698" /EC_number="2.7.8.12" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId: 7704262; Product type e: enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative CDP-glycerol:poly(glycerophosphate) glycerophosphotransferase (fragment)" /db_xref="PSEUDO:CAX52701.1" /translation="MYDLPAYRDCIRGFYFNFQQKTPGNLLQTSEELIDTVKELLHNP YIDHNYEDFYNKFCNLEEARLLKE*" /label="yvzI CDS" gene complement(3322530..3322736) /gene="yvzI" /locus_tag="BSU_35698" /old_locus_tag="BSU35698" /pseudo /label="yvzI gene" S_feature complement(3322737..3323610) /Source="Nicolas_S_feature" /locus_tag="new_3671623_3672496_c" /HighExp="HiOs, Heat, BMM, MG 15, GM 90, MG 25, MG 150, C30, GM 25, MG 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.99943499999999996" /TUshortSig="SigA, SigD" /TUshortPSig="1, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1368" promotor_-10 complement(3323604..3323623) /Source="Nicolas_upshift_promotors" /id="U2793" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=3053 /SigmaFactorBS="gtgctgatgatttacatttttaaagagcCTTAACTtttatag gaacaTATGCTATTATTGTTTATTAttaatggaacgtaaaaaatatgtcgaaatgata a" /listShort="S1368, yvzI, ggaA, S1366, ggaB, S1365, yvzH, S1364" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3323610) /Source="Nicolas_upshifts" /id="U2793" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=3053 /SigmaFactorBS="gtgctgatgatttacatttttaaagagcCTTAACTtttatag gaacaTATGCTATTATTGTTTATTAttaatggaacgtaaaaaatatgtcgaaatgata a" /listShort="S1368, yvzI, ggaA, S1366, ggaB, S1365, yvzH, S1364" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3323612..3323851) /Source="Nicolas_S_feature" /locus_tag="new_3672498_3672737_c" /HighExp="Cold, LBGstat, C30, GM 25, GM 15, GM 45, GM 60, GM 10, GM-0.2, GM 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1369" promotor_-35 complement(3323636..3323642) /Source="Nicolas_upshift_promotors" /id="U2793" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.55044955044955" /psig=1 /xcortree=3053 /SigmaFactorBS="gtgctgatgatttacatttttaaagagcCTTAACTtttatag gaacaTATGCTATTATTGTTTATTAttaatggaacgtaaaaaatatgtcgaaatgata a" /listShort="S1368, yvzI, ggaA, S1366, ggaB, S1365, yvzH, S1364" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3323833..3323851) /Source="Nicolas_upshift_promotors" /id="U2794" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=2827 /SigmaFactorBS="ttcactaaattttaccacgaaaatttttaggaactacgtATT ACAATtccttcacgttttGACGATGAAGTAATATGAGgagggcgtacaaaataaatga c" /listShort="S1369, S1368, yvzI, ggaA, S1366, ggaB, S1365, yvzH" /listLong="S1364" /label="promotor_-10" upshifts complement(3323851) /Source="Nicolas_upshifts" /id="U2794" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=2827 /SigmaFactorBS="ttcactaaattttaccacgaaaatttttaggaactacgtATT ACAATtccttcacgttttGACGATGAAGTAATATGAGgagggcgtacaaaataaatga c" /listShort="S1369, S1368, yvzI, ggaA, S1366, ggaB, S1365, yvzH" /listLong="S1364" /label="upshifts" promotor_-35 complement(3323865..3323872) /Source="Nicolas_upshift_promotors" /id="U2794" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=2827 /SigmaFactorBS="ttcactaaattttaccacgaaaatttttaggaactacgtATT ACAATtccttcacgttttGACGATGAAGTAATATGAGgagggcgtacaaaataaatga c" /listShort="S1369, S1368, yvzI, ggaA, S1366, ggaB, S1365, yvzH" /listLong="S1364" /label="promotor_-35" promotor_-35 3323874..3323881 /Source="Nicolas_upshift_promotors" /id="U2795" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2179 /SigmaFactorBS="tcgtcaaaacgtgaaggaattgtaataCGTAGTTCctaaaaa ttttCGTGGTAAAATTTAGTGAAGtctttatcaggctaagggactttatctaaactac g" /listShort="S1370, yvzE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3323893..3323912 /Source="Nicolas_upshift_promotors" /id="U2795" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2179 /SigmaFactorBS="tcgtcaaaacgtgaaggaattgtaataCGTAGTTCctaaaaa ttttCGTGGTAAAATTTAGTGAAGtctttatcaggctaagggactttatctaaactac g" /listShort="S1370, yvzE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3323907..3324037 /Source="Nicolas_S_feature" /locus_tag="new_3672793_3672923" /HighExp="Sw, T0.30H, LoTm, B60, T1.0H, Lbtran, C30, LBGtran, dia5, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1370" upshifts 3323907 /Source="Nicolas_upshifts" /id="U2795" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2179 /SigmaFactorBS="tcgtcaaaacgtgaaggaattgtaataCGTAGTTCctaaaaa ttttCGTGGTAAAATTTAGTGAAGtctttatcaggctaagggactttatctaaactac g" /listShort="S1370, yvzE" /GFF_Attribute="listLong" /label="upshifts" promotor_no_box 3323979..3324079 /Source="Nicolas_upshift_promotors" /id="U2796" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.711288711288711" /psig="0.104895104895105" /xcortree=14 /SigmaFactorBS="agggttgatatgatataaacgaaaatcaattagataaaggaa aaactgaacacttctgaaaaaagtgataagtttctttcactatatcctccaaaaagaa c" /listShort="yvzE" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 3324039 /Source="Nicolas_upshifts" /id="U2796" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.711288711288711" /psig="0.104895104895105" /xcortree=14 /SigmaFactorBS="agggttgatatgatataaacgaaaatcaattagataaaggaa aaactgaacacttctgaaaaaagtgataagtttctttcactatatcctccaaaaagaa c" /listShort="yvzE" /GFF_Attribute="listLong" /label="upshifts" CDS 3324043..3324639 /gene="yvzE" /locus_tag="BSU_35699" /old_locus_tag="BSU35699" /EC_number="2.7.7.9" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; Product type e : enzyme" /pseudo /codon_start=1 /transl_table=11 /product="putative UTP-glucose-1-phosphate uridylyltransferase (UDP-glucose pyrophosphorylase) (UDPGP) (fragment)" /db_xref="PSEUDO:CAX52702.1" /translation="MISFFHYILQKEPKGLGHAVWFAPNFIGDEPFAFLLGDDIVQAD TPGLRQLTDEYERTLSSIIGVQQVPEDETHCYGIIAPLTSEGRRYQVKNFIEKPPKDT APSNLAILGRYVFTPEIFMYLEEQQVGAGGEIQLTDAIQKLNEIQRVFAYDFEGKRYD VGEKLGFITTTLEFAMQDKELRDQLVPFMEGLLNKEEI*" /label="yvzE CDS" gene 3324043..3324639 /gene="yvzE" /locus_tag="BSU_35699" /old_locus_tag="BSU35699" /pseudo /label="yvzE gene" downshifts 3324237 /Source="Nicolas_upshifts" /id="D1844" /incds=1 /nref=94 /ntot=183 /MaxReadThrough="4.62614" /MaxDrop="5.15039" /score="34.2325445" /energy="-14.3" /TU="U2792,U2795" /idTUdmin="U2796" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3324678..3326261) /gene="tagH" /locus_tag="BSU_35700" /old_locus_tag="BSU35700" /EC_number="3.6.3.40" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7565096, 12682299, 17012386, 18156271; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ATP-binding teichoic acid precursor transporter component" /protein_id="NP_391451.1" /db_xref="EnsemblGenomes-Gn:BSU35700" /db_xref="EnsemblGenomes-Tr:CAB15587" /db_xref="GOA:P42954" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR015860" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030284" /db_xref="SubtiList:BG11191" /db_xref="UniProtKB/Swiss-Prot:P42954" /translation="MKLKVSFRNVSKQYHLYKKQSDKIKGLFFPAKDNGFFAVRNVSF DVYEGETIGFVGINGSGKSTMSNLLAKIIPPTSGEIEMNGQPSLIAIAAGLNNQLTGR DNVRLKCLMMGLTNKEIDDMYDSIVEFAEIGDFINQPVKNYSSGMKSRLGFAISVHID PDILIIDEALSVGDQTFYQKCVDRINEFKKQGKTIFFVSHSIGQIEKMCDRVAWMHYG ELRMFDETKTVVKEYKAFIDWFNKLSKKEKETYKKEQTEERKKEDPEAFARFRKKKKK PKSLANAIQIAILSILTVFMAGTMFFNAPLRTIASFGAIPQNEVKNHHGDAKGKSEER LTAINKQGFIANEKAAAYKDQGLKQKADVTLPFGTKVTVAAKGKQAAKIKFDGHSYYV KQSAVATNMKHAELHATAFTSYVSQNAASSYEYFLKFLGDSSTSIQSKLNGYTEGNKA DGRKTLNFDYEKISYVLENDKATELIFHNISPINPASLSLSDSDVLYDSSKKRFLVNT DDQVFAVDNEEHTLTLMLK*" /label="tagH CDS" gene complement(3324678..3326261) /gene="tagH" /locus_tag="BSU_35700" /old_locus_tag="BSU35700" /label="tagH gene" downshifts 3324721 /Source="Nicolas_upshifts" /id="D1845" /incds=0 /nref=2 /ntot=19 /MaxReadThrough="1.20059" /MaxDrop="5.25978" /score="34.2325445" /energy="-14.3" /TU="NA" /idTUdmin="U2792" /TUdmin=440 /isTUend="FALSE" /label="downshifts" CDS complement(3326281..3327108) /gene="tagG" /locus_tag="BSU_35710" /old_locus_tag="BSU35710" /function="16.8: Protect" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7565096, 12682299, 15849754, 16850406, 17012386, 18156271, 27213893; Product type t: transporter" /codon_start=1 /transl_table=11 /product="teichoic acid precursors permease" /protein_id="NP_391452.1" /db_xref="EnsemblGenomes-Gn:BSU35710" /db_xref="EnsemblGenomes-Tr:CAB15588" /db_xref="GOA:P42953" /db_xref="InterPro:IPR000412" /db_xref="InterPro:IPR013525" /db_xref="SubtiList:BG11205" /db_xref="UniProtKB/Swiss-Prot:P42953" /translation="MNDLLRILREQITSFPLILRLAAYETKSKYQMNYLGVLWQFLNP LIQMLAYWFVFGMGIRKGGPVTTGAGEVPFIIWMLAGLIPWFFISPTILDGSNSVFKR INMVAKMNFPISSLPSVAIASNLFSYMIMMVIYIIVLLVNGVFPSVHWLQYIYYFICM IAFMFSFSLFNSTISVLIRDYQFLLQAVTRLLFFLLPIFWDVNAKLGQSHPELVPVLK LNPLFYIIEGFRNSFLDGAWFFHDMKYTLYFWLFTFLLLLVGSILHMKFRDKFVDFL* " /label="tagG CDS" gene complement(3326281..3327108) /gene="tagG" /locus_tag="BSU_35710" /old_locus_tag="BSU35710" /label="tagG gene" S_feature complement(3327109..3327173) /Source="Nicolas_S_feature" /locus_tag="new_3675995_3676059_c" /HighExp="H2O2, LBGstat, dia15, Oxctl, LBGexp, G150, Paraq, G180, G135, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1371" promotor_-10 complement(3327169..3327188) /Source="Nicolas_upshift_promotors" /id="U2797" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.93006993006993" /psig="0.999000999001" /xcortree=1823 /SigmaFactorBS="ggcagctttttagatacttgttgagaAGTGaaaaaaaatgca ggaTCTGTTACAATAATCAGCGGtgctttcaaattttaaacagaaagattcccaaaaa c" /listShort="S1371, tagG, tagH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3327173) /Source="Nicolas_upshifts" /id="U2797" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.93006993006993" /psig="0.999000999001" /xcortree=1823 /SigmaFactorBS="ggcagctttttagatacttgttgagaAGTGaaaaaaaatgca ggaTCTGTTACAATAATCAGCGGtgctttcaaattttaaacagaaagattcccaaaaa c" /listShort="S1371, tagG, tagH" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3327175..3327272) /Source="Nicolas_S_feature" /locus_tag="new_3676061_3676158_c" /HighExp="G180, G135, Cold, G150, LPh, S0, Oxctl, Paraq, HPh, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1372" promotor_-35 complement(3327204..3327207) /Source="Nicolas_upshift_promotors" /id="U2797" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.93006993006993" /psig="0.999000999001" /xcortree=1823 /SigmaFactorBS="ggcagctttttagatacttgttgagaAGTGaaaaaaaatgca ggaTCTGTTACAATAATCAGCGGtgctttcaaattttaaacagaaagattcccaaaaa c" /listShort="S1371, tagG, tagH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3327273..3329513) /gene="tagF" /locus_tag="BSU_35720" /old_locus_tag="BSU35720" /EC_number="2.7.8.12" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12682299, 16141206, 16689786, 17012386, 18723614, 19520862, 20400947" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16141206, 16689786, 17012386, 18723614, 19520862, 20400947; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="CDP-glycerol:polyglycerol phosphate glycero-phosphotransferase (poly(glycerol phosphate) polymerase)" /protein_id="NP_391453.1" /db_xref="EnsemblGenomes-Gn:BSU35720" /db_xref="EnsemblGenomes-Tr:CAB15589" /db_xref="GOA:P13485" /db_xref="InterPro:IPR007554" /db_xref="SubtiList:BG10725" /db_xref="UniProtKB/Swiss-Prot:P13485" /translation="MSLVVDTNKRKQKGKSFYTEEQKKVMIENTVIKCILKSLKNNLG SLELLISIDSEHQFLEDYQLFLKLKERRSGTESEFPLQNTGSLEYKTEINAHVLPMPV EMGQTYDFYVEFRKKYEDAEQEPLLKRLSAEVNSIERAFHVDQTTELLILPYTTDKGN FSIKVKREAKIIRFDQIEISSEEISITGYAGYLSSENQYRIKNLNLILKKGGETPIEE KFPIKLERKTHGLENMRADGFVPELYDFEVKVPLKEIPFSNEKRYVYRLFMEYICNDD EGTDIQFNSTALVLGDRKNKLKGLVSIIKTNNAPVRYEVFKKKKKQTLGIRVNDYSLK TRMKYFIKGKKKRLVSKIKKITKMRNKLITKTYKSLFMMASRMPVKRKTVIFESFNGK QYSCNPRAIYEYMRENHPEYKMYWSVNKQYSAPFDEKGIPYINRLSLKWLFAMARAEY WVVNSRLPLWIPKPSHTTYLQTWHGTPLKRLAMDMEEVHMPGTNTKKYKRNFIKEASN WDYLISPNGYSTEIFTRAFQFNKTMIESGYPRNDFLHNDNNEETISLIKSRLNIPRDK KVILYAPTWRDDQFYAKGRYKFDLDLDLHQLRQELGNEYIVILRMHYLVAENFDLGPF EGFAYDFSAYEDIRELYMVSDLLITDYSSVFFDFANLKRPMLFFVPDIETYRDKLRGF YFDFEKEAPGPLVKTTEETIEAIKQISSPDYKLPVSFGPFYDKFCYLESGRSSEKVVN TVFKAE*" /label="tagF CDS" gene complement(3327273..3329513) /gene="tagF" /locus_tag="BSU_35720" /old_locus_tag="BSU35720" /label="tagF gene" CDS complement(3329513..3331534) /gene="tagE" /locus_tag="BSU_35730" /old_locus_tag="BSU35730" /EC_number="2.4.1.52" /function="16.8: Protect" /function="16.5: Explore" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:2507871, 9457886, 12682299, 16141206, 16689786, 17012386, 21558268" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2507871, 9457886, 12682299, 16141206, 16689786, 17012386, 21558268; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-glucose:polyglycerol phosphate alpha-glucosyltransferase" /protein_id="NP_391454.1" /db_xref="EnsemblGenomes-Gn:BSU35730" /db_xref="EnsemblGenomes-Tr:CAB15590" /db_xref="GOA:P13484" /db_xref="InterPro:IPR001296" /db_xref="InterPro:IPR015397" /db_xref="SubtiList:BG10724" /db_xref="UniProtKB/Swiss-Prot:P13484" /translation="MSLHAVSESNIKQIPDMDYYFISGGLPSNYGGLTKSLLLRSKLF GEECNQNTFFLTFRFDLELSSKIDELYSNGKIDKKFTSVINLFDDFLSVRTNGKRSYE ERIGLDQIKKQVGMGKFAKTLLRLFGKKNNEMSVVYYGDGETIRYVDYWNDKNQLIKR EEYTKNGNLVLVTHYDVQLNKMYLQEYINDQNQVYLDKLYVWNNEEKDVQLSHIIWYS LEGEIKVKDESELRQYWIEYLQKQNDKPKLFLVDSRPQDKHVFKVKKSPSSYYGAIIH NKHYGSNKYQIKGRYKEVFSQMYNLDAVFFITEEQLEDFKLISGEQETFFFTPHTIDK PLDPAVLNVPSEKYKAVIISRLASMKNLIHAVKAFSLVVKEIPEAKLDIFGSGEDFEK IKKEIEDTKLQNNVFLKGYTDNPDSEFQKAWLTISTSHFEGFGLSNMEALSNGCPVVT YDYDYGARSLVTDGANGYVIEQYNIEKLGQAIISLMKDESTHQKFSEQAFKMAEKYSR PNYIENWAFALNQMIEVRIEREKFSKKVGKKDPSISSYTEDFDKTKIEIDIENFDHND IKKIRLVGLDRKNKAEIISTNLQNDQLFVIDLEKDVNIEKIAANKTQVIDFYIVFNAN GHIKTMRRLSSEETKLSGNSIDTNNGYRVEPYTTVKGNFSWRVTEIKES*" /label="tagE CDS" gene complement(3329513..3331534) /gene="tagE" /locus_tag="BSU_35730" /old_locus_tag="BSU35730" /label="tagE gene" promotor_-35 3330276..3330285 /Source="Nicolas_upshift_promotors" /id="U2798" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1685 /SigmaFactorBS="gaggttgaaatggttagccaagcttttTGAAACTCTGagtca gggttatCCGTATAGCCTTTCAAaaagacattgttctgcagtttggtatcttcaattt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3330298..3330313 /Source="Nicolas_upshift_promotors" /id="U2798" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1685 /SigmaFactorBS="gaggttgaaatggttagccaagcttttTGAAACTCTGagtca gggttatCCGTATAGCCTTTCAAaaagacattgttctgcagtttggtatcttcaattt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3330309 /Source="Nicolas_upshifts" /id="U2798" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1685 /SigmaFactorBS="gaggttgaaatggttagccaagcttttTGAAACTCTGagtca gggttatCCGTATAGCCTTTCAAaaagacattgttctgcagtttggtatcttcaattt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3331535..3331694) /Source="Nicolas_S_feature" /locus_tag="new_3680421_3680580_c" /HighExp="G180, G135, Cold, G150, Oxctl, LBGexp, Paraq, Lbexp, LPhT, LoTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1373" CDS complement(3331695..3332084) /gene="tagD" /locus_tag="BSU_35740" /old_locus_tag="BSU35740" /EC_number="2.7.7.39" /function="16.8: Protect" /function="16.5: Explore" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11673441, 12637027, 12637499, 12682299, 16141206, 16689786, 17012386, 21558268" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11673441, 12637027, 12637499, 12682299, 16141206, 16689786, 17012386, 21558268; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycerol-3-phosphate cytidylyltransferase" /protein_id="NP_391455.1" /db_xref="EnsemblGenomes-Gn:BSU35740" /db_xref="EnsemblGenomes-Tr:CAB15591" /db_xref="GOA:P27623" /db_xref="InterPro:IPR004821" /db_xref="InterPro:IPR006409" /db_xref="InterPro:IPR014729" /db_xref="PDB:1COZ" /db_xref="PDB:1N1D" /db_xref="SubtiList:BG10449" /db_xref="UniProtKB/Swiss-Prot:P27623" /translation="MKKVITYGTFDLLHWGHIKLLERAKQLGDYLVVAISTDEFNLQK QKKAYHSYEHRKLILETIRYVDEVIPEKNWEQKKQDIIDHNIDVFVMGDDWEGKFDFL KDQCEVVYLPRTEGISTTKIKEEIAGL*" /label="tagD CDS" gene complement(3331695..3332084) /gene="tagD" /locus_tag="BSU_35740" /old_locus_tag="BSU35740" /label="tagD gene" S_feature complement(3332085..3332219) /Source="Nicolas_S_feature" /locus_tag="new_3680971_3681105_c" /HighExp="BC, Cold, T3.0H, HiOs, MG-0.2, T1.30H, T3.30H, LPhT, MG 15, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1374" promotor_-10 complement(3332203..3332222) /Source="Nicolas_upshift_promotors" /id="U2799" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2289 /SigmaFactorBS="taattacatattttggaatgtttttctcctcatgagtacTTA ACCTTttttaggcggTATGCTATAATTAATGATCAgtgaagacatacgagaaatatgt c" /listShort="S1374, tagD, S1373, tagE, tagF, S1372, S1371, tagG, tagH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3332219) /Source="Nicolas_upshifts" /id="U2799" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2289 /SigmaFactorBS="taattacatattttggaatgtttttctcctcatgagtacTTA ACCTTttttaggcggTATGCTATAATTAATGATCAgtgaagacatacgagaaatatgt c" /listShort="S1374, tagD, S1373, tagE, tagF, S1372, S1371, tagG, tagH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3332233..3332240) /Source="Nicolas_upshift_promotors" /id="U2799" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2289 /SigmaFactorBS="taattacatattttggaatgtttttctcctcatgagtacTTA ACCTTttttaggcggTATGCTATAATTAATGATCAgtgaagacatacgagaaatatgt c" /listShort="S1374, tagD, S1373, tagE, tagF, S1372, S1371, tagG, tagH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3332374..3332380 /Source="Nicolas_upshift_promotors" /id="U2800" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp=1 /psig=1 /xcortree=2129 /SigmaFactorBS="gtaaaattggaaacatatttaaatttaatgtaaagataatgt tAATCCTTtgttgaagattTATGTTAAAATATAAGGTAGcttgattttgcttttagaa a" /listShort="S1375, tagA, tagB, tagC" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3332391..3332483 /Source="Nicolas_S_feature" /locus_tag="new_3681277_3681369" /HighExp="B60, LoTm, Cold, T3.30H, T3.0H, Salt, T5.0H, T4.0H, Lbexp, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1375" upshifts 3332391 /Source="Nicolas_upshifts" /id="U2800" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp=1 /psig=1 /xcortree=2129 /SigmaFactorBS="gtaaaattggaaacatatttaaatttaatgtaaagataatgt tAATCCTTtgttgaagattTATGTTAAAATATAAGGTAGcttgattttgcttttagaa a" /listShort="S1375, tagA, tagB, tagC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3332392..3332411 /Source="Nicolas_upshift_promotors" /id="U2800" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp=1 /psig=1 /xcortree=2129 /SigmaFactorBS="gtaaaattggaaacatatttaaatttaatgtaaagataatgt tAATCCTTtgttgaagattTATGTTAAAATATAAGGTAGcttgattttgcttttagaa a" /listShort="S1375, tagA, tagB, tagC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3332484..3333254 /gene="tagA" /locus_tag="BSU_35750" /old_locus_tag="BSU35750" /EC_number="2.4.1.187" /function="16.5: Explore" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12682299, 16141206, 16689786, 16953575, 17012386, 18156271, 19376878" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16141206, 16689786, 16953575, 17012386, 18156271, 19376878; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetylmannosamine (ManNAc) C4 hydroxyl of a membrane-anchored N-acetylglucosaminyl diphospholipid (GlcNAc-pp-undecaprenyl, lipid I) glycosyltransferase" /protein_id="NP_391456.1" /db_xref="EnsemblGenomes-Gn:BSU35750" /db_xref="EnsemblGenomes-Tr:CAB15592" /db_xref="GOA:P27620" /db_xref="InterPro:IPR004629" /db_xref="InterPro:IPR034714" /db_xref="SubtiList:BG10450" /db_xref="UniProtKB/Swiss-Prot:P27620" /translation="MQTETIHNIPYVNSNLTSFIDYLEKHYIDQKIGAVISTVNPEIA FAAIKDRDYFDVLSSSNFILPDGIGVVMMSRLTNNRLQSRIAGYDVFKELLGVANKKK KRIFLYGAKKDVIKGVVSKISSEYPNIKIAGYSDGYVQDRTLVAKQIARANPDMVFVA LGYPHQEKFIHNYRHLFPKAVSIGLGGSFDVFSGNVKRAPSWMIRLNLEWFYRLILNP WRWKRMLSIPKYALTVLKEEKNKKTFYPKPEKDHTKQI*" /label="tagA CDS" gene 3332484..3333254 /gene="tagA" /locus_tag="BSU_35750" /old_locus_tag="BSU35750" /label="tagA gene" S_feature complement(3332611..3332959) /Source="Nicolas_S_feature" /locus_tag="new_3681497_3681845_c" /HighExp="S8, S6, S7, S5, S4, G135, S3, C30, G180, ferm" /AntisenseName="tagA" /AntisenseCor="-0.35014495927301897" /AntisenseRegPval="-8.5" /CDS_PredictionProba="NA" /TUshortSig="SigGF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1376" promotor_-10 complement(3332963..3332974) /Source="Nicolas_upshift_promotors" /id="U2801" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=949 /SigmaFactorBS="atacggctttagggaacaagtgtctgtagttaTGAATGAatt tctcttgatgaGGATACCCTAAAgctacgaataccatgtcaggatttgctcttgcaat t" /listShort="S1376" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3332967) /Source="Nicolas_upshifts" /id="U2801" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=949 /SigmaFactorBS="atacggctttagggaacaagtgtctgtagttaTGAATGAatt tctcttgatgaGGATACCCTAAAgctacgaataccatgtcaggatttgctcttgcaat t" /listShort="S1376" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3332989..3332995) /Source="Nicolas_upshift_promotors" /id="U2801" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=949 /SigmaFactorBS="atacggctttagggaacaagtgtctgtagttaTGAATGAatt tctcttgatgaGGATACCCTAAAgctacgaataccatgtcaggatttgctcttgcaat t" /listShort="S1376" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3333279 /Source="Nicolas_upshifts" /id="D1846" /incds=0 /nref=2 /ntot=103 /MaxReadThrough="6.64821" /MaxDrop="3.225" /score="-6.01444425" /energy="-10.9" /TU="U2800" /idTUdmin="U2800" /TUdmin="-2310" /isTUend="FALSE" /label="downshifts" CDS 3333287..3334432 /gene="tagB" /locus_tag="BSU_35760" /old_locus_tag="BSU35760" /EC_number="2.7.8.44" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:12682299, 16141206, 16150696, 16689786, 17012386, 17660278, 18156271, 18761696" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16141206, 16150696, 16689786, 17012386, 17660278, 18156271, 18761696; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="teichoic acid primase, CDP-glycerol:N-acetyl-beta-d-mannosaminyl-1, 4-N-acetyl-d-glucosaminyldiphosphoundecaprenyl glycerophosphotransferase" /protein_id="NP_391457.1" /db_xref="EnsemblGenomes-Gn:BSU35760" /db_xref="EnsemblGenomes-Tr:CAB15593" /db_xref="GOA:P27621" /db_xref="InterPro:IPR007554" /db_xref="SubtiList:BG10451" /db_xref="UniProtKB/Swiss-Prot:P27621" /translation="MKIRSLLANCYLYFLSAIAFFLQWVKPESKVTLLISFEANAKAI LEEYEQGQYSYKLNILYTQQASAIAESFPNVDAYLLQEKNPIHLIKAVYLMFNSKVII TDNYFLLTSVLNKRKQTKCIQVWHANGSLKKFGLEDITNMQRTKTDIKRFQKVYSSYD YLTVGSEEMANIFKKSFGIKDNQLLKIGVPLTDPYYRENKKKISDTLNIQRKKIILYA PTFRDYNMQSIQLPFTEEQLIHQLKEEYVLFVKLHPAIQNNIDIKYSSDYIKDVSNYA LFDLLMAADILITDYSSVPFEFSILNKPILFYTYDLKLYQQKRGLVDNYLSIIPGRAC YDSESLINEIQTPFNYSKIKVFSDRWNKYSDGNSSQNLLNFIENLIS*" /label="tagB CDS" gene 3333287..3334432 /gene="tagB" /locus_tag="BSU_35760" /old_locus_tag="BSU35760" /label="tagB gene" downshifts 3334420 /Source="Nicolas_upshifts" /id="D1847" /incds=0 /nref=101 /ntot=235 /MaxReadThrough="3.54908" /MaxDrop="5.95551" /score="-3.22062454" /energy="-10" /TU="U2800" /idTUdmin="U2800" /TUdmin="-1169" /isTUend="FALSE" /label="downshifts" promotor_-35 3334474..3334481 /Source="Nicolas_upshift_promotors" /id="U2802" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.894105894105894" /psig=1 /xcortree=1505 /SigmaFactorBS="ttcaaaacagaacaagtgttcttttttcTATTGAATaccgaa cgtatgttTGCTTTAATGTAATTAGTTGcttatggcagcaaataataatagaggtggt a" /listShort="tagC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3334496..3334515 /Source="Nicolas_upshift_promotors" /id="U2802" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.894105894105894" /psig=1 /xcortree=1505 /SigmaFactorBS="ttcaaaacagaacaagtgttcttttttcTATTGAATaccgaa cgtatgttTGCTTTAATGTAATTAGTTGcttatggcagcaaataataatagaggtggt a" /listShort="tagC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3334506 /Source="Nicolas_upshifts" /id="U2802" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.894105894105894" /psig=1 /xcortree=1505 /SigmaFactorBS="ttcaaaacagaacaagtgttcttttttcTATTGAATaccgaa cgtatgttTGCTTTAATGTAATTAGTTGcttatggcagcaaataataatagaggtggt a" /listShort="tagC" /GFF_Attribute="listLong" /label="upshifts" CDS 3334552..3335880 /gene="tagC" /locus_tag="BSU_35770" /old_locus_tag="BSU35770" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7952180, 16269821; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative polyglycerol phosphate assembly and export protein (teichoic acid biosynthesis)" /protein_id="NP_391458.1" /db_xref="EnsemblGenomes-Gn:BSU35770" /db_xref="EnsemblGenomes-Tr:CAB15594" /db_xref="GOA:P27622" /db_xref="InterPro:IPR011042" /db_xref="SubtiList:BG10453" /db_xref="UniProtKB/Swiss-Prot:P27622" /translation="MRKKELFDFTNITPKLFTELRVADKTVLQSFNFDEKNHQIYTTQ VASGLGKDNTQSYRITRLSLEGLQLDSMLLKHGGHGTNIGIENRNGTIYIWSLYDKPN ETDKSELVCFPYKAGATLDENSKELQRFSNMPFDHRVTPALDMKNRQLAIRQYDTKNN NNKQWVTIFNLDDAIANKNNPLYTINIPDELHYLQGFFLDDGYLYWYTGDTNSKSYPN LITVFDSDNKIVLQKEITVGKDLSTRYENNFREPEGICMYTNPETGAKSLMVGITSGK EGNRISRIYAYHSYENFMNHVPMLRSPLLKTVGHQDTPPERFQPFIQTFILEYNAQNK KWMVPTSGYLPSYTSNLVRNITINADGNLQVTLNERYISLLHQSIEGDFRLKQKDIRM GSWYFAGGEKSNVLEIGFMKGSTKIRPDDAAISNASRMSIFMIVADKIEV*" /label="tagC CDS" gene 3334552..3335880 /gene="tagC" /locus_tag="BSU_35770" /old_locus_tag="BSU35770" /label="tagC gene" downshifts 3335875 /Source="Nicolas_upshifts" /id="D1848" /incds=0 /nref=1 /ntot=29 /MaxReadThrough="2.77356" /MaxDrop="4.002" /score="-7.52215775" /energy="-19.3" /TU="NA" /idTUdmin="U2802" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(3335936) /Source="Nicolas_upshifts" /id="D1849" /incds=0 /nref=141 /ntot=248 /MaxReadThrough="0.94732" /MaxDrop="5.40128" /score="-0.11635468" /energy="-19.3" /TU="NA" /idTUdmin="U2803" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" CDS complement(3335940..3338582) /gene="lytD" /locus_tag="BSU_35780" /old_locus_tag="BSU35780" /EC_number="3.2.1.96" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:9537764, 10206711, 17298895, 19542270, 22469514" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9537764, 10206711, 17298895, 19542270, 22469514; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exported N-acetylglucosaminidase (major autolysin) (CWBP90)" /protein_id="NP_391459.1" /db_xref="EnsemblGenomes-Gn:BSU35780" /db_xref="EnsemblGenomes-Tr:CAB15595" /db_xref="GOA:P39848" /db_xref="InterPro:IPR002901" /db_xref="InterPro:IPR003646" /db_xref="InterPro:IPR007730" /db_xref="InterPro:IPR036680" /db_xref="SubtiList:BG10455" /db_xref="UniProtKB/Swiss-Prot:P39848" /translation="MKKRLIAPMLLSAASLAFFAMSGSAQAAAYTDYSLYKVEPSNTF STESQASQAVAKLEKDTGWDASYQASGTTTTYQISASGIHSESEAKAILSGLAKQTSI TGTSSPVGSKQPYVTISSGAISGEKQANTILAKLKQETGVAGAVKAYGAAQPYMNVMT SDIADETKVKALIQSLAKQTGIKSSYQPITHTVSVTTIQSGTIVGDSRAAQIKNAFQK ESGLQASLKETVKGQAYYTFTTAAISGEANAKTLLQQLKQSTGITGSYKSINQKTTVE SYNVQSAYFKGLSTVKDAISQIKKNTGVSGSYQQVGKSTSYTVNMKGITKQQLQKIDT FFKKKKWHYTSSSVKKTTTSAAYQITTAKILGEQQANKAAAFFAQKKVKAAKTAAGST AENQYQLISEETSDQAKVTKGLNILKKNQLSASAKSVKKQIADTFKITTESLLDQTKV NQALTFFKSNHISVASQKTGQTAASSYQITTEAIISQEEIDRVLTFFKQNHIAVTTSK TGQTAYTQYKIVTTQLSSKTALNNGLTYLKSKSVTPSYTTKSNTLYKISVNEQFTGND TAAAASTKLKQLYGWTSSIVKIKNGPQIMKTNYNLSLRDMVQKQMTVSPQTDGAAYVS LTYINTATSTVTADVLNIRSTPEVSPTNVIGQFKKGDKVKVIGQINGWAKINLGWRNA SSDEVVQYVDPNNFSRDSKYYFQFLKLSQTAGLSVTEVNQKVLAGKGILTGRAKAFID AANQYSINELYLISHALLETGNGTSALANGLTYNGKTVYNMYGIGAYDSNPNYYGAKY AYEQGWFTPEAAIIGGAKFIGSSYIHNTAYNQDTLYKMRWSATATHQYATDIGWAYKQ VNRMYSLYSLLDGYTLYFDVPEYR*" /label="lytD CDS" gene complement(3335940..3338582) /gene="lytD" /locus_tag="BSU_35780" /old_locus_tag="BSU35780" /label="lytD gene" promotor_-10 complement(3337185..3337204) /Source="Nicolas_upshift_promotors" /id="U2803" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1231 /SigmaFactorBS="gatcaaacgaaagtcaatcagGCACTCACGTttttcaaatcg aATCATATATCAGTAGCAAGCcagaaaaccggtcagacagctgcgagcagctatcaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3337187) /Source="Nicolas_upshifts" /id="U2803" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1231 /SigmaFactorBS="gatcaaacgaaagtcaatcagGCACTCACGTttttcaaatcg aATCATATATCAGTAGCAAGCcagaaaaccggtcagacagctgcgagcagctatcaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3337217..3337226) /Source="Nicolas_upshift_promotors" /id="U2803" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1231 /SigmaFactorBS="gatcaaacgaaagtcaatcagGCACTCACGTttttcaaatcg aATCATATATCAGTAGCAAGCcagaaaaccggtcagacagctgcgagcagctatcaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3338617..3338635) /Source="Nicolas_upshift_promotors" /id="U2804" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2808 /SigmaFactorBS="tttattagaaaatggaagtgattcacCTATAAATgaagcatg cgcgtGCCGATAAATAAACTAGTTttatatactcatagaataagaaagaggagaagga a" /listShort="lytD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3338622) /Source="Nicolas_upshifts" /id="U2804" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2808 /SigmaFactorBS="tttattagaaaatggaagtgattcacCTATAAATgaagcatg cgcgtGCCGATAAATAAACTAGTTttatatactcatagaataagaaagaggagaagga a" /listShort="lytD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3338649..3338656) /Source="Nicolas_upshift_promotors" /id="U2804" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2808 /SigmaFactorBS="tttattagaaaatggaagtgattcacCTATAAATgaagcatg cgcgtGCCGATAAATAAACTAGTTttatatactcatagaataagaaagaggagaagga a" /listShort="lytD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3338711..3339661) /gene="pmiA" /locus_tag="BSU_35790" /old_locus_tag="BSU35790" /EC_number="5.3.1.8" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7581999, 10704478, 19447949, 27435445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7581999, 10704478, 19447949, 27435445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="mannose-6-phosphate isomerase (active on aldose substrates with hydroxyl groups oriented in the same direction at the C-2 and C-3 positions as in mannose)" /protein_id="NP_391460.1" /db_xref="EnsemblGenomes-Gn:BSU35790" /db_xref="EnsemblGenomes-Tr:CAB15596" /db_xref="GOA:P39841" /db_xref="InterPro:IPR001250" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014628" /db_xref="InterPro:IPR014710" /db_xref="PDB:1QWR" /db_xref="SubtiList:BG10454" /db_xref="UniProtKB/Swiss-Prot:P39841" /translation="MTQSPIFLTPVFKEKIWGGTALRDRFGYSIPSESTGECWAISAH PKGPSTVANGPYKGKTLIELWEEHREVFGGVEGDRFPLLTKLLDVKEDTSIKVHPDDY YAGENEEGELGKTECWYIIDCKENAEIIYGHTARSKTELVTMINSGDWEGLLRRIKIK PGDFYYVPSGTLHALCKGALVLETQQNSDATYRVYDYDRLDSNGSPRELHFAKAVNAA TVPHVDGYIDESTESRKGITIKTFVQGEYFSVYKWDINGEAEMAQDESFLICSVIEGS GLLKYEDKTCPLKKGDHFILPAQMPDFTIKGTCTLIVSHI*" /label="pmiA CDS" gene complement(3338711..3339661) /gene="pmiA" /locus_tag="BSU_35790" /old_locus_tag="BSU35790" /label="pmiA gene" downshifts complement(3338723) /Source="Nicolas_upshifts" /id="D1850" /incds=0 /nref=29 /ntot=177 /MaxReadThrough="4.74566" /MaxDrop="3.72936" /score="9.64549533" /energy="-7.7" /TU="U2805" /idTUdmin="U2806" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3339686..3339704) /Source="Nicolas_upshift_promotors" /id="U2805" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=167 /SigmaFactorBS="cataggaaaaaggcagcttatacgggCGTTTGTaagaggggc gcaccGGGAAAATGATGATCAGTTatttacaggggaggggtacggatcatgacgcaat c" /listShort="yvyI, lytD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3339691) /Source="Nicolas_upshifts" /id="U2805" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=167 /SigmaFactorBS="cataggaaaaaggcagcttatacgggCGTTTGTaagaggggc gcaccGGGAAAATGATGATCAGTTatttacaggggaggggtacggatcatgacgcaat c" /listShort="yvyI, lytD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3339693..3339829) /Source="Nicolas_S_feature" /locus_tag="new_3688579_3688715_c" /HighExp="Lbtran, S0, M40t90, T1.0H, dia0, Mt0, Lbstat, M0t90, Lbexp, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.17043900000000001" /TUshortSig="SigA" /TUshortPSig="0.994" /TUlongSig="NA" /TUlongPSig="NA" /label="S1377" promotor_-35 complement(3339719..3339725) /Source="Nicolas_upshift_promotors" /id="U2805" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=167 /SigmaFactorBS="cataggaaaaaggcagcttatacgggCGTTTGTaagaggggc gcaccGGGAAAATGATGATCAGTTatttacaggggaggggtacggatcatgacgcaat c" /listShort="yvyI, lytD" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(3339803..3339822) /Source="Nicolas_upshift_promotors" /id="U2806" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.664335664335664" /psig="0.994005994005994" /xcortree=1553 /SigmaFactorBS="tattaatttgtatcaaaaaaggagaattattcttatcgagga aaaggctgaaacaaagcttcttttcgaCGTGATATAATAGATAGGAAgcgttttcttt g" /listShort="S1377, yvyI" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3339831) /Source="Nicolas_upshifts" /id="U2806" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.664335664335664" /psig="0.994005994005994" /xcortree=1553 /SigmaFactorBS="tattaatttgtatcaaaaaaggagaattattcttatcgagga aaaggctgaaacaaagcttcttttcgaCGTGATATAATAGATAGGAAgcgttttcttt g" /listShort="S1377, yvyI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3339859..3339865 /Source="Nicolas_upshift_promotors" /id="U2807" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=900 /SigmaFactorBS="cacgtcgaaaagaagctttgtttcagccttttcctcgataAG AATAAttctccttttttgATACAAATTAATaaaaaccgtcaatatgtttaagaaggag a" /listShort="gerBA, gerBB, gerBC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3339879..3339890 /Source="Nicolas_upshift_promotors" /id="U2807" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=900 /SigmaFactorBS="cacgtcgaaaagaagctttgtttcagccttttcctcgataAG AATAAttctccttttttgATACAAATTAATaaaaaccgtcaatatgtttaagaaggag a" /listShort="gerBA, gerBB, gerBC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3339879 /Source="Nicolas_upshifts" /id="U2807" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=900 /SigmaFactorBS="cacgtcgaaaagaagctttgtttcagccttttcctcgataAG AATAAttctccttttttgATACAAATTAATaaaaaccgtcaatatgtttaagaaggag a" /listShort="gerBA, gerBB, gerBC" /GFF_Attribute="listLong" /label="upshifts" CDS 3339926..3341377 /gene="gerBA" /locus_tag="BSU_35800" /old_locus_tag="BSU35800" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:3110007, 8012571, 10411756, 15774895, 22493018, 23749970, 25681191, 25790435" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3110007, 8012571, 10411756, 15774895, 22493018, 23749970, 25681191, 25790435; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="component of germinant receptor B" /protein_id="NP_391461.2" /db_xref="EnsemblGenomes-Gn:BSU35800" /db_xref="EnsemblGenomes-Tr:CAB15597" /db_xref="GOA:P39569" /db_xref="InterPro:IPR004995" /db_xref="SubtiList:BG10640" /db_xref="UniProtKB/Swiss-Prot:P39569" /translation="MQIDSDLQNNLDTLKKTLGQNDDMMFYTFAFGDSRQKACLLYID GLTENKMLAQYVISPLQKEALAHKECSIEDLSAFFFGFHHSVVSTMKEIEQLVFSGQA ILLADGYRGGLAFDTKSVATRSLDEPSSEVVERGPKIGFIEKLRTNTALLRERTSDPN LVIKEMTLGKRTKKKIAVAYIQDIAPDYVVKEVFKRLKSVNIDNLPESGTLEQLIEDE PFSIFPTILSTERPDRVESSLLEGRVSILVDGTPFALIVPATVDEFIHSPDDYSQRWI PMSLVRLLRYSSILITIYLPGLYISLVSFHTGLLPTRMAISIAGSRLNVPFPPFVEAF IMIFTIELIREAGLRLPKPIGQTIGLIGGVVIGQAAVQAQIVSALMVIVVSVTALASF TVPSYAYNFPLRIIRIGVMISATALGMYGVIMVYLFVIGHLMRLKSFGQDYIIPIMAQ PGQDLKDTVIRIPTMFLKRRPTRNDPEDNIRQR*" /label="gerBA CDS" gene 3339926..3341377 /gene="gerBA" /locus_tag="BSU_35800" /old_locus_tag="BSU35800" /label="gerBA gene" CDS 3341383..3342489 /gene="gerBB" /locus_tag="BSU_35810" /old_locus_tag="BSU35810" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:15774895, 15849754, 16352818, 16850406, 22493018" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15774895, 15849754, 16352818, 16850406, 22493018; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="component of germinant receptor B" /protein_id="NP_391462.2" /db_xref="EnsemblGenomes-Gn:BSU35810" /db_xref="EnsemblGenomes-Tr:CAB15598" /db_xref="GOA:P39570" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004761" /db_xref="SubtiList:BG10641" /db_xref="UniProtKB/Swiss-Prot:P39570" /translation="MRKSEHKLTFMQTLIMISSTLIGAGVLTLPRSAAETGSPSGWLM ILLQGVIFIIIVLLFLPFLQKNSGKTLFKLNSIVAGKFIGFLLNLYICLYFIGIVCFQ ARILGEVVGFFLLKNTPMAVVVFIFLAVAIYHVGGGVYSIAKVYAYIFPITLIIFMML LMFSFRLFQLDFIRPVFEGGYQSFFSLFPKTLLYFSGFEIIFYLVPFMRDPKQVKKAV ALGIATSTLFYSITLLIVIGCMTVAEAKTVTWPTISLIHALEVPGIFIERFDLFLQLT WTAQQFACMLGSFKGAHIGLTEIFHLKNKNNAWLLTAMLAATFFITMYPKDLNDVFYY GTLLGYAFLIVITIPFFVWFLSWIQKKIGRGQLQ*" /label="gerBB CDS" gene 3341383..3342489 /gene="gerBB" /locus_tag="BSU_35810" /old_locus_tag="BSU35810" /label="gerBB gene" CDS 3342486..3343610 /gene="gerBC" /locus_tag="BSU_35820" /old_locus_tag="BSU35820" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:15774895, 15849754, 16352818, 16850406, 20654628, 21685283, 22493018" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15774895, 15849754, 16352818, 16850406, 20654628, 21685283, 22493018; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="lipoprotein component of the germination receptor B" /protein_id="NP_391463.1" /db_xref="EnsemblGenomes-Gn:BSU35820" /db_xref="EnsemblGenomes-Tr:CAB15599" /db_xref="GOA:P39571" /db_xref="InterPro:IPR008844" /db_xref="PDB:3N54" /db_xref="SubtiList:BG10642" /db_xref="UniProtKB/Swiss-Prot:P39571" /translation="MKTASKFSVMFFMLLALCGCWDVKDIEQLSFARGLAIDETNDHQ YKLTYQNLLPQSEDSQASGKPEFVNVTSHGKTILEAVSDVSIKDPPVYSDHLKVILLG EKLMRNQNVDQVLNHFIRDDELRRSSYLMAARGNAADVFTKGNPNQQQPMPSEKLIDL TTHSGYNGKIMIPLRIGRASVYSQNGYSYLIQAVKNEKGKAKYDGAGIIKRGSNKLVG FLSADETQTLSWVMGTIQGGVMPTTDKGHPITFEIKKSKTKIKPVIENGKPVFHISVK TKGILTEDQNPNENSFSKSYLHRLENIFEKKLERDVKQVMDKLQHEYKTDPVFLSDHI RIQHPDYWNKVKGHWDEIFSETDFKYDISFKIINFGTVGK*" /label="gerBC CDS" gene 3342486..3343610 /gene="gerBC" /locus_tag="BSU_35820" /old_locus_tag="BSU35820" /label="gerBC gene" S_feature complement(3342713..3343607) /Source="Nicolas_S_feature" /locus_tag="new_3691599_3692493_c" /HighExp="Etha, Sw, Salt, Heat, S8, B36, Gly, S7, LPhT, S6" /AntisenseName="gerBC" /AntisenseCor="0.12062795031199899" /AntisenseRegPval="-1.3" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1378" downshifts 3343600 /Source="Nicolas_upshifts" /id="D1851" /incds=0 /nref=18 /ntot=72 /MaxReadThrough="0.37711" /MaxDrop="4.85405" /score="35.6875936" /energy="-14.9" /TU="NA" /idTUdmin="U2807" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3343647..3345020) /gene="ywtG" /locus_tag="BSU_35830" /old_locus_tag="BSU35830" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative carbohydrate/proton transporter" /protein_id="NP_391464.2" /db_xref="EnsemblGenomes-Gn:BSU35830" /db_xref="EnsemblGenomes-Tr:CAB15600" /db_xref="GOA:C0SPB2" /db_xref="InterPro:IPR003663" /db_xref="InterPro:IPR005828" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12538" /db_xref="UniProtKB/Swiss-Prot:C0SPB2" /translation="MKKQSNIWLYFFGALGGALYGYDTGVISGAILFMKKELGLNAFT EGLVVSSLLVGAILGSGAAGKLTDRFGRKKAIMAAALLFCIGGLGVALAPNTGVMVLF RIILGLAVGTSTTIVPLYLSELAPKHKRGALSSLNQLMITVGILLSYIVNYIFADAEA WRWMLGLAAVPSLLLLIGILFMPESPRWLFTNGEESKAKKILEKLRGTKDIDQEIHDI KEAEKQDEGGLKELFDPWVRPALIAGLGLAFLQQFIGTNTIIYYAPKTFTNVGFGNSA SILGTVGIGTVNVLMTLVAIKIIDKIGRKPLLLFGNAGMVISLIVLALVNLFFDNTPA ASWTTVICLGVFIVVFAVSWGPVVWVMLPELFPLHVRGIGTGVSTLMLHVGTLIVSLT YPILMEAIGISYLFLIYAAIGIMAFLFVRFKVTETKGRSLEEIEQDLRDKNGQGGAAG KQQTVGT*" /label="ywtG CDS" gene complement(3343647..3345020) /gene="ywtG" /locus_tag="BSU_35830" /old_locus_tag="BSU35830" /label="ywtG gene" downshifts complement(3343652) /Source="Nicolas_upshifts" /id="D1852" /incds=0 /nref=13 /ntot=90 /MaxReadThrough="6.08746" /MaxDrop="3.99424" /score="22.7548183" /energy="-16.7" /TU="U2808" /idTUdmin="U2808" /TUdmin="-900" /isTUend="FALSE" /label="downshifts" S_feature complement(3345021..3345084) /Source="Nicolas_S_feature" /locus_tag="new_3693907_3693970_c" /HighExp="Etha, Salt, Gly, Heat, Sw, LPhT, HiTm, Diami, B60, UNK1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1379" promotor_-10 complement(3345072..3345090) /Source="Nicolas_upshift_promotors" /id="U2808" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=188 /SigmaFactorBS="atgattggaaaacttatgatcagaaaaataaaaaGGTTTAAt ggccggaaaaagaGGCTAAAAGATTTCTAAAAaaatcccacagacaatgtcattgcag c" /listShort="S1379, ywtG, S1378" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3345085) /Source="Nicolas_upshifts" /id="U2808" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=188 /SigmaFactorBS="atgattggaaaacttatgatcagaaaaataaaaaGGTTTAAt ggccggaaaaagaGGCTAAAAGATTTCTAAAAaaatcccacagacaatgtcattgcag c" /listShort="S1379, ywtG, S1378" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3345105..3345111) /Source="Nicolas_upshift_promotors" /id="U2808" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=188 /SigmaFactorBS="atgattggaaaacttatgatcagaaaaataaaaaGGTTTAAt ggccggaaaaagaGGCTAAAAGATTTCTAAAAaaatcccacagacaatgtcattgcag c" /listShort="S1379, ywtG, S1378" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3345171..3345180 /Source="Nicolas_upshift_promotors" /id="U2809" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1659 /SigmaFactorBS="ttttccaatcatttacttgtatttttttcaatgtcgcCGAAA CATTTtacctgctgcgGCGTCCAATATAAGGTgattcagtacattatcgttatcaatt t" /listShort="S1380, ywtF, S1381, ywtE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3345192..3345207 /Source="Nicolas_upshift_promotors" /id="U2809" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1659 /SigmaFactorBS="ttttccaatcatttacttgtatttttttcaatgtcgcCGAAA CATTTtacctgctgcgGCGTCCAATATAAGGTgattcagtacattatcgttatcaatt t" /listShort="S1380, ywtF, S1381, ywtE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3345194..3345314 /Source="Nicolas_S_feature" /locus_tag="new_3694080_3694200" /HighExp="T-0.40H, LBGstat, T-1.10H, T0.30H, Heat, T-1.40H, T1.30H, T1.0H, T0.0H, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1380" upshifts 3345194 /Source="Nicolas_upshifts" /id="U2809" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1659 /SigmaFactorBS="ttttccaatcatttacttgtatttttttcaatgtcgcCGAAA CATTTtacctgctgcgGCGTCCAATATAAGGTgattcagtacattatcgttatcaatt t" /listShort="S1380, ywtF, S1381, ywtE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3345289..3345296 /Source="Nicolas_upshift_promotors" /id="U2810" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.58041958041958" /psig="0.997002997002997" /xcortree=2249 /SigmaFactorBS="tataggaatatttatcgaaaaatgtctttcgagTAGTTGCCc catggcaaatagAATGGTACGCTTCAAATATTaaagaaacgtgaggtattgatatatg g" /listShort="ywtF, S1381, ywtE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3345310..3345329 /Source="Nicolas_upshift_promotors" /id="U2810" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.58041958041958" /psig="0.997002997002997" /xcortree=2249 /SigmaFactorBS="tataggaatatttatcgaaaaatgtctttcgagTAGTTGCCc catggcaaatagAATGGTACGCTTCAAATATTaaagaaacgtgaggtattgatatatg g" /listShort="ywtF, S1381, ywtE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3345316 /Source="Nicolas_upshifts" /id="U2810" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.58041958041958" /psig="0.997002997002997" /xcortree=2249 /SigmaFactorBS="tataggaatatttatcgaaaaatgtctttcgagTAGTTGCCc catggcaaatagAATGGTACGCTTCAAATATTaaagaaacgtgaggtattgatatatg g" /listShort="ywtF, S1381, ywtE" /GFF_Attribute="listLong" /label="upshifts" CDS 3345353..3346321 /gene="tagT" /locus_tag="BSU_35840" /old_locus_tag="BSU35840" /function="12: Regulatory functions" /experiment="publication(s) with functional evidences, PMID:19099556, 22432711, 29107701" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19099556, 22432711, 29107701; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="teichoic acid-peptidoglycan tethering enzyme (LCP component) with transcription regulator domain of capsule synthesis" /protein_id="NP_391465.2" /db_xref="EnsemblGenomes-Gn:BSU35840" /db_xref="EnsemblGenomes-Tr:CAB15601" /db_xref="GOA:Q7WY78" /db_xref="InterPro:IPR004474" /db_xref="PDB:3MEJ" /db_xref="PDB:4DE9" /db_xref="SubtiList:BG12537" /db_xref="UniProtKB/Swiss-Prot:Q7WY78" /translation="MEERSQRRKKKRKLKKWVKVVAGLMAFLVIAAGSVGAYAFVKLN NASKEAHVSLARGEQSVKRIKEFDPGKDSFSVLLLGIDAREKNGETVDQARSDANVLV TFNRKEKTAKMLSIPRDAYVNIPGHGYDKFTHAHAYGGVDLTVKTVEEMLDIPVDYVV ESNFTAFEDVVNELNGVKVTVKSDKVIQQIKKDTKGKVVLQKGTHTLDGEEALAYVRT RKADSDLLRGQRQMEVLSAIIDKSKSLSSIPAYDDIVDTMGQNLKMNLSLKDAIGLFP FITSLKSVESIQLTGYDYEPAGVYYFKLNQQKLQEVKKELQNDLGV*" /label="tagT CDS" gene 3345353..3346321 /gene="tagT" /locus_tag="BSU_35840" /old_locus_tag="BSU35840" /label="tagT gene" downshifts 3346306 /Source="Nicolas_upshifts" /id="D1853" /incds=0 /nref=27 /ntot=139 /MaxReadThrough="6.07699" /MaxDrop="4.78541" /score="17.3040761" /energy="-17.8" /TU="U2809,U2810" /idTUdmin="U2809" /TUdmin="-1012" /isTUend="FALSE" /label="downshifts" promotor_-35 3346365..3346372 /Source="Nicolas_upshift_promotors" /id="U2811" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.667332667332667" /psig="0.982017982017982" /xcortree=1778 /SigmaFactorBS="cgattacgccatcccgttttacatatttcctTGTTGAAAatt atcaaagtaacGTTTAGCCTTAATTTATATGgattatgtttcacaggcaagctgaaca t" /listShort="S1381, ywtE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3346387..3346406 /Source="Nicolas_upshift_promotors" /id="U2811" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.667332667332667" /psig="0.982017982017982" /xcortree=1778 /SigmaFactorBS="cgattacgccatcccgttttacatatttcctTGTTGAAAatt atcaaagtaacGTTTAGCCTTAATTTATATGgattatgtttcacaggcaagctgaaca t" /listShort="S1381, ywtE" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3346394..3346476 /Source="Nicolas_S_feature" /locus_tag="new_3695280_3695362" /HighExp="Etha, dia5, Lbtran, dia15, LBGexp, LBGtran, G150, Mt0, G180, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigWXY" /TUshortPSig="0.982, 0.997, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1381" upshifts 3346394 /Source="Nicolas_upshifts" /id="U2811" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.667332667332667" /psig="0.982017982017982" /xcortree=1778 /SigmaFactorBS="cgattacgccatcccgttttacatatttcctTGTTGAAAatt atcaaagtaacGTTTAGCCTTAATTTATATGgattatgtttcacaggcaagctgaaca t" /listShort="S1381, ywtE" /GFF_Attribute="listLong" /label="upshifts" CDS 3346477..3347337 /gene="ribZB" /locus_tag="BSU_35850" /old_locus_tag="BSU35850" /EC_number="3.1.3.-" /function="4.9: Riboflavin, FMN, and FAD" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 26316208; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5-amino-6-ribitylamino-2,4(1H, 3H)-pyrimidinedione 5'-phosphate phosphatase (promiscuous activity)" /protein_id="NP_391466.1" /db_xref="EnsemblGenomes-Gn:BSU35850" /db_xref="EnsemblGenomes-Tr:CAB15602" /db_xref="GOA:P96741" /db_xref="InterPro:IPR000150" /db_xref="InterPro:IPR006379" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG12536" /db_xref="UniProtKB/Swiss-Prot:P96741" /translation="MKCIAIDLDGTLLNKESVISAENREAIKRAVDAGILVTICTGRA TFDVKALLDDLDIPIIAANGGTIHDTGYRLISRTLMDQEAGKAIADYLLSKNIYFEVY TDDHLLSPFDGEAKLHAELDILKSANPNEQTDDLWQGAMTQFKQFGIKPIPHIESVFD GGENIYKLLCFSFDMDKLKQAKEELKHHKKLAQTSSGKHIIEILPASSGKGRALTKLA DIYGIETQDIYAIGDSPNDLSMFEVAGHRIAMENAIDELKEKSTFVTKSNDENGVAYF IDQLLSGQYA*" /label="ribZB CDS" gene 3346477..3347337 /gene="ribZB" /locus_tag="BSU_35850" /old_locus_tag="BSU35850" /label="ribZB gene" downshifts 3347318 /Source="Nicolas_upshifts" /id="D1854" /incds=0 /nref=163 /ntot=235 /MaxReadThrough="3.35965" /MaxDrop="5.65658" /score="24.125299" /energy="-9.8" /TU="NA" /idTUdmin="U2809" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3347371..3348612) /gene="pgdS" /locus_tag="BSU_35860" /old_locus_tag="BSU35860" /EC_number="3.4.19.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12073126, 12644511, 16689787, 16952838, 26158264, 28664519" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12073126, 12644511, 16689787, 16952838, 26158264, 28664519; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="gamma-DD-glutamyl hydrolase (PGA depolymerase)" /protein_id="NP_391467.1" /db_xref="EnsemblGenomes-Gn:BSU35860" /db_xref="EnsemblGenomes-Tr:CAB15603" /db_xref="GOA:P96740" /db_xref="InterPro:IPR000064" /db_xref="SubtiList:BG12535" /db_xref="UniProtKB/Swiss-Prot:P96740" /translation="MNTLANWKKFLLVAVIICFLVPIMTKAEIAEADTSSELIVSEAK NLLGYQYKYGGETPKEGFDPSGLIQYVFSKADIHLPRSVNDQYKIGTAVKPENLKPGD ILFFKKEGSTGTVPTHDALYIGDGQMVHSTQSKGVIITNYKKSSYWSGTYIGARRIAA DPATADVPVVQEAEKYIGVPYVFGGSTPSEGFDCSGLVQYVFQQALGIYLPRSAEQQW AVGEKVAPQNIKPGDVVYFSNTYKTGISHAGIYAGAGRFIQASRSEKVTISYLSEDYW KSKMTGIRRFDNLTIPKENPIVSEATLYVGEVPYKQGGVTPETGFDTAGFVQYVYQKA AGISLPRYATSQYNAGTKIEKADLKPGDIVFFQSTSLNPSIYIGNGQVVHVTLSNGVT ITNMNTSTYWKDKYAGSIRVQ*" /label="pgdS CDS" gene complement(3347371..3348612) /gene="pgdS" /locus_tag="BSU_35860" /old_locus_tag="BSU35860" /label="pgdS gene" downshifts complement(3347390) /Source="Nicolas_upshifts" /id="D1855" /incds=0 /nref=228 /ntot=317 /MaxReadThrough="2.27329" /MaxDrop="7.15996" /score="10.2499259" /energy="-9.8" /TU="NA" /idTUdmin="U2812" /TUdmin="-18" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3348634..3348652) /Source="Nicolas_upshift_promotors" /id="U2812" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2804 /SigmaFactorBS="ttatttgcccagcatattcattctgtaaaaatattaaaaagt ctCTTAACATattcaaaaaaatACCGATGTTAAAACTGCAAaaagaggaggagataat a" /listShort="pgdS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3348656) /Source="Nicolas_upshifts" /id="U2812" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2804 /SigmaFactorBS="ttatttgcccagcatattcattctgtaaaaatattaaaaagt ctCTTAACATattcaaaaaaatACCGATGTTAAAACTGCAAaaagaggaggagataat a" /listShort="pgdS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3348665..3348672) /Source="Nicolas_upshift_promotors" /id="U2812" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2804 /SigmaFactorBS="ttatttgcccagcatattcattctgtaaaaatattaaaaagt ctCTTAACATattcaaaaaaatACCGATGTTAAAACTGCAAaaagaggaggagataat a" /listShort="pgdS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3348753..3348920) /gene="edmS" /locus_tag="BSU_35870" /old_locus_tag="BSU35870" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:16267300, 16689787, 20812257, 21357437, 23583563, 25843804" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16267300, 16689787, 20812257, 21357437, 23583563, 25843804; Product type f : factor" /codon_start=1 /transl_table=11 /product="factor required extrachromosomal elements maintenance" /protein_id="NP_391468.1" /db_xref="EnsemblGenomes-Gn:BSU35870" /db_xref="EnsemblGenomes-Tr:CAB15604" /db_xref="SubtiList:BG12534" /db_xref="UniProtKB/Swiss-Prot:P96739" /translation="MKFVKAIWPFVAVAIVFMFMSAFKFNDQLTDQEKQKIDMEMNKI QQQEEPVNANK*" /label="edmS CDS" gene complement(3348753..3348920) /gene="edmS" /locus_tag="BSU_35870" /old_locus_tag="BSU35870" /label="edmS gene" downshifts complement(3348780) /Source="Nicolas_upshifts" /id="D1856" /incds=0 /nref=1 /ntot=47 /MaxReadThrough="0.6752" /MaxDrop="2.78178" /score="24.9141523" /energy="-14.7" /TU="NA" /idTUdmin="U2812" /TUdmin="-1408" /isTUend="FALSE" /label="downshifts" CDS complement(3348935..3350077) /gene="capA" /locus_tag="BSU_35880" /old_locus_tag="BSU35880" /EC_number="6.3.2.-" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11606194, 11751809, 12644511, 16689787, 19745567, 27818647" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11606194, 11751809, 12644511, 16689787, 19745567, 27818647; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="capsular polyglutamate synthetase (acid resistance)" /protein_id="NP_391469.1" /db_xref="EnsemblGenomes-Gn:BSU35880" /db_xref="EnsemblGenomes-Tr:CAB15605" /db_xref="InterPro:IPR019079" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG12533" /db_xref="UniProtKB/Swiss-Prot:P96738" /translation="MKKELSFHEKLLKLTKQQKKKTNKHVFIAIPIVFVLMFAFMWAG KAETPKVKTYSDDVLSASFVGDIMMGRYVEKVTEQKGADSIFQYVEPIFRASDYVAGN FENPVTYQKNYKQADKEIHLQTNKESVKVLKDMNFTVLNSANNHAMDYGVQGMKDTLG EFAKQNLDIVGAGYSLSDAKKKISYQKVNGVTIATLGFTDVSGKGFAAKKNTPGVLPA DPEIFIPMISEAKKHADIVVVQSHWGQEYDNDPNDRQRQLARAMSDAGADIIVGHHPH VLEPIEVYNGTVIFYSLGNFVFDQGWTRTRDSALVQYHLKKNGTGRFEVTPIDIHEAT PAPVKKDSLKQKTIIRELTKDSNFAWKVEDGKLTFDIDHSDKLKSK*" /label="capA CDS" gene complement(3348935..3350077) /gene="capA" /locus_tag="BSU_35880" /old_locus_tag="BSU35880" /label="capA gene" CDS complement(3350096..3350545) /gene="capC" /locus_tag="BSU_35890" /old_locus_tag="BSU35890" /EC_number="6.3.2.-" /function="16.13: Shape" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11606194, 11751809, 15849754, 16689787, 16850406, 19734658" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11606194, 11751809, 15849754, 16689787, 16850406, 19734658; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="capsular polyglutamate amide ligase/translocase subunit" /protein_id="NP_391470.1" /db_xref="EnsemblGenomes-Gn:BSU35890" /db_xref="EnsemblGenomes-Tr:CAB15606" /db_xref="GOA:P96737" /db_xref="InterPro:IPR008338" /db_xref="SubtiList:BG12532" /db_xref="UniProtKB/Swiss-Prot:P96737" /translation="MFGSDLYIALILGVLLSLIFAEKTGIVPAGLVVPGYLGLVFNQP VFILLVLLVSLLTYVIVKYGLSKFMILYGRRKFAAMLITGIVLKIAFDFLYPIVPFEI AEFRGIGIIVPGLIANTIQKQGLTITFGSTLLLSGATFAIMFVYYLI*" /label="capC CDS" gene complement(3350096..3350545) /gene="capC" /locus_tag="BSU_35890" /old_locus_tag="BSU35890" /label="capC gene" promotor_-35 3350239..3350245 /Source="Nicolas_upshift_promotors" /id="U2813" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.853146853146853" /psig="0.853146853146853" /xcortree=131 /SigmaFactorBS="ttggcaattaaacctggcacgatgatgccgattcctcgaaat tctgCGATTTCaaatggtacaatcGGGTATAGAAAATCAAACGcgatttttaggacga t" /listShort="S1382" /listLong="rbsR, rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /label="promotor_-35" upshifts 3350253 /Source="Nicolas_upshifts" /id="U2813" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.853146853146853" /psig="0.853146853146853" /xcortree=131 /SigmaFactorBS="ttggcaattaaacctggcacgatgatgccgattcctcgaaat tctgCGATTTCaaatggtacaatcGGGTATAGAAAATCAAACGcgatttttaggacga t" /listShort="S1382" /listLong="rbsR, rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /label="upshifts" promotor_-10 3350259..3350277 /Source="Nicolas_upshift_promotors" /id="U2813" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.853146853146853" /psig="0.853146853146853" /xcortree=131 /SigmaFactorBS="ttggcaattaaacctggcacgatgatgccgattcctcgaaat tctgCGATTTCaaatggtacaatcGGGTATAGAAAATCAAACGcgatttttaggacga t" /listShort="S1382" /listLong="rbsR, rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /label="promotor_-10" S_feature 3350266..3352475 /Source="Nicolas_S_feature" /locus_tag="new_3699152_3701361" /HighExp="Sw, Salt, dia5, BC, B60, Diami, Lbstat, H2O2, dia15, Gly" /AntisenseName="pgsB" /AntisenseCor="7.6745622610153399E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="0.40410200000000002" /TUshortSig="SigB" /TUshortPSig="0.853" /TUlongSig="NA" /TUlongPSig="NA" /label="S1382" CDS complement(3350560..3351741) /gene="capB" /locus_tag="BSU_35900" /old_locus_tag="BSU35900" /EC_number="6.3.2.-" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11606194, 11751809, 12644511, 16689787, 19420703, 19734658, 27446033; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="capsular polyglutamate synthetase (ATP-dependentamide ligase)" /protein_id="NP_391471.2" /db_xref="EnsemblGenomes-Gn:BSU35900" /db_xref="EnsemblGenomes-Tr:CAB15607" /db_xref="GOA:P96736" /db_xref="InterPro:IPR008337" /db_xref="InterPro:IPR013221" /db_xref="InterPro:IPR036565" /db_xref="SubtiList:BG12531" /db_xref="UniProtKB/Swiss-Prot:P96736" /translation="MWLLIIACAVILVIGILEKRRHQKNIDALPVRVNINGIRGKSTV TRLTTGILIEAGYKTVGKTTGTDARMIYWDTPEEKPIKRKPQGPNIGEQKEVMRETVE RGANAIVSECMAVNPDYQIIFQEELLQANIGVIVNVLEDHMDVMGPTLDEIAEAFTAT IPYNGHLVITDSEYTEFFKQKAKERNTKVIIADNSKITDEYLRKFEYMVFPDNASLAL GVAQALGIDEETAFKGMLNAPPDPGAMRILPLISPSEPGHFVNGFAANDASSTLNIWK RVKEIGYPTDDPIIIMNCRADRVDRTQQFANDVLPYIEASELILIGETTEPIVKAYEE GKIPADKLHDLEYKSTDEIMELLKKRMHNRVIYGVGNIHGAAEPLIEKIHEYKVKQLV S*" /label="capB CDS" gene complement(3350560..3351741) /gene="capB" /locus_tag="BSU_35900" /old_locus_tag="BSU35900" /label="capB gene" promotor_-35 3352455..3352462 /Source="Nicolas_upshift_promotors" /id="U2814" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig=1 /xcortree=326 /SigmaFactorBS="atatatacaatttacaattagatttcttttgatattttTATT GCTAacttcggattgttcaTGATAATCTATCTATGTAAAcggttacataaacaaggag g" /listShort="rbsR, rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3352477 /Source="Nicolas_upshifts" /id="U2814" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig=1 /xcortree=326 /SigmaFactorBS="atatatacaatttacaattagatttcttttgatattttTATT GCTAacttcggattgttcaTGATAATCTATCTATGTAAAcggttacataaacaaggag g" /listShort="rbsR, rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3352478..3352497 /Source="Nicolas_upshift_promotors" /id="U2814" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.911088911088911" /psig=1 /xcortree=326 /SigmaFactorBS="atatatacaatttacaattagatttcttttgatattttTATT GCTAacttcggattgttcaTGATAATCTATCTATGTAAAcggttacataaacaaggag g" /listShort="rbsR, rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3352498) /Source="Nicolas_upshifts" /id="U2815" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=694 /SigmaFactorBS="ccgccgctccggcgacatctttaattgtaGCCAAaacagctC CTCCTTGTTTATGTaaccgtttacatagatagattatcatgaacaatccgaagttagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3352503..3352517) /Source="Nicolas_upshift_promotors" /id="U2815" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=694 /SigmaFactorBS="ccgccgctccggcgacatctttaattgtaGCCAAaacagctC CTCCTTGTTTATGTaaccgtttacatagatagattatcatgaacaatccgaagttagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3352525..3352529) /Source="Nicolas_upshift_promotors" /id="U2815" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=694 /SigmaFactorBS="ccgccgctccggcgacatctttaattgtaGCCAAaacagctC CTCCTTGTTTATGTaaccgtttacatagatagattatcatgaacaatccgaagttagc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3352525..3353505 /gene="rbsR" /locus_tag="BSU_35910" /old_locus_tag="BSU35910" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11750820, 16519689" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11750820, 16519689; Product type r: regulator" /codon_start=1 /transl_table=11 /product="ribose operon repressor (LacI family, D-ribose)" /protein_id="NP_391472.1" /db_xref="EnsemblGenomes-Gn:BSU35910" /db_xref="EnsemblGenomes-Tr:CAB15608" /db_xref="GOA:P36944" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG10876" /db_xref="UniProtKB/Swiss-Prot:P36944" /translation="MATIKDVAGAAGVSVATVSRNLNDNGYVHEETRTRVIAAMAKLN YYPNEVARSLYKRESRLIGLLLPDITNPFFPQLARGAEDELNREGYRLIFGNSDEELK KELEYLQTFKQNHVAGIIAATNYPDLEEYSGMNYPVVFLDRTLEGAPSVSSDGYTGVK LAAQAIIHGKSQRITLLRGPAHLPTAQDRFNGALEILKQAEVDFQVIETASFSIKDAQ SMAKELFASYPATDGVIASNDIQAAAVLHEALRRGKNVPEDIQIIGYDDIPQSGLLFP PLSTIKQPAYDMGKEAAKLLLGIIKKQPLAETAIQMPVTYIGRKTTRKED*" /label="rbsR CDS" gene 3352525..3353505 /gene="rbsR" /locus_tag="BSU_35910" /old_locus_tag="BSU35910" /label="rbsR gene" promotor_-35 3353354..3353361 /Source="Nicolas_upshift_promotors" /id="U2816" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.759240759240759" /xcortree=1571 /SigmaFactorBS="cgcaaagcggacttctgttcccgcCACTTTCTacaattaaac agcCCGCATATGATATGGGGAAAgaagctgccaaactgcttttgggtatcattaaaaa a" /listShort="rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3353375..3353394 /Source="Nicolas_upshift_promotors" /id="U2816" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.759240759240759" /xcortree=1571 /SigmaFactorBS="cgcaaagcggacttctgttcccgcCACTTTCTacaattaaac agcCCGCATATGATATGGGGAAAgaagctgccaaactgcttttgggtatcattaaaaa a" /listShort="rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3353390 /Source="Nicolas_upshifts" /id="U2816" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.532467532467532" /psig="0.759240759240759" /xcortree=1571 /SigmaFactorBS="cgcaaagcggacttctgttcccgcCACTTTCTacaattaaac agcCCGCATATGATATGGGGAAAgaagctgccaaactgcttttgggtatcattaaaaa a" /listShort="rbsK, rbsD, rbsA, rbsC, rbsB, ywsB" /GFF_Attribute="listLong" /label="upshifts" CDS 3353507..3354388 /gene="rbsK" /locus_tag="BSU_35920" /old_locus_tag="BSU35920" /EC_number="2.7.1.15" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7921236, 16978644; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribokinase" /protein_id="NP_391473.1" /db_xref="EnsemblGenomes-Gn:BSU35920" /db_xref="EnsemblGenomes-Tr:CAB15609" /db_xref="GOA:P36945" /db_xref="InterPro:IPR002139" /db_xref="InterPro:IPR002173" /db_xref="InterPro:IPR011611" /db_xref="InterPro:IPR011877" /db_xref="InterPro:IPR029056" /db_xref="SubtiList:BG10877" /db_xref="UniProtKB/Swiss-Prot:P36945" /translation="MRNICVIGSCSMDLVVTSDKRPKAGETVLGTSFQTVPGGKGANQ AVAAARLGAQVFMVGKVGDDHYGTAILNNLKANGVRTDYMEPVTHTESGTAHIVLAEG DNSIVVVKGANDDITPAYALNALEQIEKVDMVLIQQEIPEETVDEVCKYCHSHDIPII LNPAPARPLKQETIDHATYLTPNEHEASILFPELTISEALALYPAKLFITEGKQGVRY SAGSKEVLIPSFPVEPVDTTGAGDTFNAAFAVALAEGKDIEAALRFANRAASLSVCSF GAQGGMPTRNEVEELLS*" /label="rbsK CDS" gene 3353507..3354388 /gene="rbsK" /locus_tag="BSU_35920" /old_locus_tag="BSU35920" /label="rbsK gene" CDS 3354385..3354780 /gene="rbsD" /locus_tag="BSU_35930" /old_locus_tag="BSU35930" /EC_number="5.4.99.62" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 7921236, 12738765, 21276853; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-ribose pyranase" /protein_id="NP_391474.1" /db_xref="EnsemblGenomes-Gn:BSU35930" /db_xref="EnsemblGenomes-Tr:CAB15610" /db_xref="GOA:P36946" /db_xref="InterPro:IPR007721" /db_xref="InterPro:IPR023064" /db_xref="InterPro:IPR023750" /db_xref="PDB:1OGC" /db_xref="PDB:1OGD" /db_xref="PDB:1OGE" /db_xref="PDB:1OGF" /db_xref="SubtiList:BG10878" /db_xref="UniProtKB/Swiss-Prot:P36946" /translation="MKKHGILNSHLAKILADLGHTDKIVIADAGLPVPDGVLKIDLSL KPGLPAFQDTAAVLAEEMAVEKVIAAAEIKASNQENAKFLENLFSEQEIEYLSHEEFK LLTKDAKAVIRTGEFTPYANCILQAGVLF*" /label="rbsD CDS" gene 3354385..3354780 /gene="rbsD" /locus_tag="BSU_35930" /old_locus_tag="BSU35930" /label="rbsD gene" CDS 3354796..3356277 /gene="rbsA" /locus_tag="BSU_35940" /old_locus_tag="BSU35940" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7921236" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7921236; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ribose ABC transporter (ATP-binding protein)" /protein_id="NP_391475.1" /db_xref="EnsemblGenomes-Gn:BSU35940" /db_xref="EnsemblGenomes-Tr:CAB15611" /db_xref="GOA:P36947" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR015861" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10879" /db_xref="UniProtKB/Swiss-Prot:P36947" /translation="MQIEMKDIHKTFGKNQVLSGVSFQLMPGEVHALMGENGAGKSTL MNILTGLHKADKGQISINGNETYFSNPKEAEQHGIAFIHQELNIWPEMTVLENLFIGK EISSKLGVLQTRKMKALAKEQFDKLSVSLSLDQEAGECSVGQQQMIEIAKALMTNAEV IIMDEPTAALTEREISKLFEVITALKKNGVSIVYISHRMEEIFAICDRITIMRDGKTV DTTNISETDFDEVVKKMVGRELTERYPKRTPSLGDKVFEVKNASVKGSFEDVSFYVRS GEIVGVSGLMGAGRTEMMRALFGVDRLDTGEIWIAGKKTAIKNPQEAVKKGLGFITEN RKDEGLLLDTSIRENIALPNLSSFSPKGLIDHKREAEFVDLLIKRLTIKTASPETHAR HLSGGNQQKVVIAKWIGIGPKVLILDEPTRGVDVGAKREIYTLMNELTERGVAIIMVS SELPEILGMSDRIIVVHEGRISGEIHAREATQERIMTLATGGR*" /label="rbsA CDS" gene 3354796..3356277 /gene="rbsA" /locus_tag="BSU_35940" /old_locus_tag="BSU35940" /label="rbsA gene" CDS 3356279..3357247 /gene="rbsC" /locus_tag="BSU_35950" /old_locus_tag="BSU35950" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7921236, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7921236, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ribose ABC transporter (permease)" /protein_id="NP_391476.1" /db_xref="EnsemblGenomes-Gn:BSU35950" /db_xref="EnsemblGenomes-Tr:CAB15612" /db_xref="GOA:P36948" /db_xref="InterPro:IPR001851" /db_xref="InterPro:IPR035568" /db_xref="SubtiList:BG10880" /db_xref="UniProtKB/Swiss-Prot:P36948" /translation="MKTEQLQTEQKRIHFDGVMQKLGPFLGLFILVIIVSILNPSFLE PLNILNLLRQVAINGLIAFGMTFVILTGGIDLSVGAILALSSALVAGMIVSGVDPVLA IILGCIIGAVLGMINGLLITKGKMAPFIATLATMTVFRGLTLVYTDGNPITGLGTNYG FQMFGRGYFLGIPVPAITMVLAFVILWVLLHKTPFGRRTYAIGGNEKAALISGIKVTR VKVMIYSLAGLLSALAGAILTSRLHSAQPTAGESYELDAIAAVVLGGTSLSGGRGRIV GTLIGVLIIGTLNNGLNLLGVSSFYQLVVKGIVILIAVLLDRKKSA*" /label="rbsC CDS" gene 3356279..3357247 /gene="rbsC" /locus_tag="BSU_35950" /old_locus_tag="BSU35950" /label="rbsC gene" CDS 3357259..3358176 /gene="rbsB" /locus_tag="BSU_35960" /old_locus_tag="BSU35960" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7921236" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7921236; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ribose ABC transporter (ribose-binding lipoprotein)" /protein_id="NP_391477.1" /db_xref="EnsemblGenomes-Gn:BSU35960" /db_xref="EnsemblGenomes-Tr:CAB15613" /db_xref="GOA:P36949" /db_xref="InterPro:IPR025997" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG10881" /db_xref="UniProtKB/Swiss-Prot:P36949" /translation="MKKAVSVILTLSLFLLTACSLEPPQWAKPSNSGNKKEFTIGLSV STLNNPFFVSLKKGIEKEAKKRGMKVIIVDAQNDSSKQTSDVEDLIQQGVDALLINPT DSSAISTAVESANAVGVPVVTIDRSAEQGKVETLVASDNVKGGEMAAAFIADKLGKGA KVAELEGVPGASATRERGSGFHNIADQKLQVVTKQSADFDRTKGLTVMENLLQGHPDI QAVFAHNDEMALGALEAINSSGKDILVIGFDGNKDALASIKDRKLSATVAQQPELIGK LATEAADDILHGKKVQKTISAPLKLETQK*" /label="rbsB CDS" gene 3357259..3358176 /gene="rbsB" /locus_tag="BSU_35960" /old_locus_tag="BSU35960" /label="rbsB gene" promotor_-35 3358185..3358191 /Source="Nicolas_upshift_promotors" /id="U2817" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=144 /SigmaFactorBS="cgcctctcaaactagaaacacaaaaataattgtctgaTGTTT AGgaacctgcgataacGTGAATAGAGATATAGAATgaattatttctcttacgtgagga g" /listShort="ywsB, S1383, ywsA, S1384" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3358206..3358224 /Source="Nicolas_upshift_promotors" /id="U2817" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=144 /SigmaFactorBS="cgcctctcaaactagaaacacaaaaataattgtctgaTGTTT AGgaacctgcgataacGTGAATAGAGATATAGAATgaattatttctcttacgtgagga g" /listShort="ywsB, S1383, ywsA, S1384" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3358208 /Source="Nicolas_upshifts" /id="U2817" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=144 /SigmaFactorBS="cgcctctcaaactagaaacacaaaaataattgtctgaTGTTT AGgaacctgcgataacGTGAATAGAGATATAGAATgaattatttctcttacgtgagga g" /listShort="ywsB, S1383, ywsA, S1384" /GFF_Attribute="listLong" /label="upshifts" CDS 3358258..3358794 /gene="ywsB" /locus_tag="BSU_35970" /old_locus_tag="BSU35970" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15187182; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative cell wall binding enzyme" /protein_id="NP_391478.1" /db_xref="EnsemblGenomes-Gn:BSU35970" /db_xref="EnsemblGenomes-Tr:CAB15614" /db_xref="GOA:P96729" /db_xref="InterPro:IPR003646" /db_xref="InterPro:IPR036028" /db_xref="SubtiList:BG12530" /db_xref="UniProtKB/Swiss-Prot:P96729" /translation="MNKPTKLFSTLALAAGMTAAAAGGAGTIHAQQPETTVSIDDLYS YPIDSYLVSAEALNVRTKPSASSQKADTLHLGDSLKLISFSNADWAKVKYKNGKTGFV STHYIVKAATTVKTKTKTKVYTSADGKSIKTLPADTSVSFLGWSKTNKGGFDFDWVFV DYGGTTGYMKTKDLHMTK*" /label="ywsB CDS" gene 3358258..3358794 /gene="ywsB" /locus_tag="BSU_35970" /old_locus_tag="BSU35970" /label="ywsB gene" downshifts 3358777 /Source="Nicolas_upshifts" /id="D1857" /incds=0 /nref=187 /ntot=255 /MaxReadThrough="5.87246" /MaxDrop="7.38203" /score="26.4284327" /energy="-19" /TU="U2817" /idTUdmin="U2814" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" S_feature 3358822..3358932 /Source="Nicolas_S_feature" /locus_tag="new_3707708_3707818" /HighExp="Etha, M9-stat, Sw, M40t90, G150, B60, T0.30H, M0t90, T1.30H, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.991" /TUlongSig="NA" /TUlongPSig="NA" /label="S1383" promotor_-35 3358901..3358907 /Source="Nicolas_upshift_promotors" /id="U2818" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=889 /SigmaFactorBS="atattgtcgtatgctgtgtcgaaacctTACATGAtcatcgac atttttGTTCACGCTAAAaagcggaggtgtaaatatggatcaatttgaagcagcatat g" /listShort="ywsA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3358922..3358933 /Source="Nicolas_upshift_promotors" /id="U2818" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=889 /SigmaFactorBS="atattgtcgtatgctgtgtcgaaacctTACATGAtcatcgac atttttGTTCACGCTAAAaagcggaggtgtaaatatggatcaatttgaagcagcatat g" /listShort="ywsA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3358934 /Source="Nicolas_upshifts" /id="U2818" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=889 /SigmaFactorBS="atattgtcgtatgctgtgtcgaaacctTACATGAtcatcgac atttttGTTCACGCTAAAaagcggaggtgtaaatatggatcaatttgaagcagcatat g" /listShort="ywsA" /GFF_Attribute="listLong" /label="upshifts" CDS 3358950..3359246 /gene="ywsA" /locus_tag="BSU_35980" /old_locus_tag="BSU35980" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11782522" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391479.1" /db_xref="EnsemblGenomes-Gn:BSU35980" /db_xref="EnsemblGenomes-Tr:CAB15615" /db_xref="InterPro:IPR024997" /db_xref="SubtiList:BG12529" /db_xref="UniProtKB/Swiss-Prot:P96728" /translation="MDQFEAAYESYKARQTTADQENVPSGKEEIIAVRRNEEDNIIAV KTNTGRELDYPTALSEAKSGKLAHVDVFHKYGRDILRSEPDGIKENNLSELPDF*" /label="ywsA CDS" gene 3358950..3359246 /gene="ywsA" /locus_tag="BSU_35980" /old_locus_tag="BSU35980" /label="ywsA gene" S_feature 3359247..3359899 /Source="Nicolas_S_feature" /locus_tag="new_3708133_3708785" /HighExp="Etha, M9-stat, S5, S7, S6, Sw, S8, B60, G150, S4" /AntisenseName="ywrO" /AntisenseCor="-0.23279201478213099" /AntisenseRegPval="-3.9" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.991" /TUlongSig="NA" /TUlongPSig="NA" /label="S1384" CDS complement(3359286..3359813) /gene="ywrO" /locus_tag="BSU_35990" /old_locus_tag="BSU35990" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1b: Function from experimental evidences in the studied species; PubMedId: 11782522, 14697229, 17768344; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nitroreductase (unknown substrate)" /protein_id="NP_391480.1" /db_xref="EnsemblGenomes-Gn:BSU35990" /db_xref="EnsemblGenomes-Tr:CAB15616" /db_xref="GOA:P80871" /db_xref="InterPro:IPR003680" /db_xref="InterPro:IPR029039" /db_xref="SubtiList:BG12528" /db_xref="UniProtKB/Swiss-Prot:P80871" /translation="MKILVLAVHPHMETSVVNKAWAEELSKHDNITVRDLYKEYPDEA IDVAKEQQLCEEYDRIVFQFPLYWYSSPPLLKKWQDLVLTYGWAFGSEGNALHGKELM LAVSTGSEAEKYQAGGANHYSISELLKPFQATSNLIGMKYLPPYVFYGVNYAAAEDIS HSAKRLAEYIQQPFV*" /label="ywrO CDS" gene complement(3359286..3359813) /gene="ywrO" /locus_tag="BSU_35990" /old_locus_tag="BSU35990" /label="ywrO gene" downshifts complement(3359296) /Source="Nicolas_upshifts" /id="D1858" /incds=0 /nref=48 /ntot=208 /MaxReadThrough="3.48831" /MaxDrop="4.56453" /score="1.41593376" /energy="-17.4" /TU="U2819" /idTUdmin="U2821" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3359833..3359852) /Source="Nicolas_upshift_promotors" /id="U2819" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.603396603396603" /psig=1 /xcortree=1963 /SigmaFactorBS="aaaagaaagccccttttagcagggctttcttttTATTTGGCt cttttcctgattTTAGATAAAATAACATCAAAacagtaaaggtgtggtctgatgaaaa t" /listShort="ywrO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3359846) /Source="Nicolas_upshifts" /id="U2819" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.603396603396603" /psig=1 /xcortree=1963 /SigmaFactorBS="aaaagaaagccccttttagcagggctttcttttTATTTGGCt cttttcctgattTTAGATAAAATAACATCAAAacagtaaaggtgtggtctgatgaaaa t" /listShort="ywrO" /GFF_Attribute="listLong" /label="upshifts" downshifts 3359857 /Source="Nicolas_upshifts" /id="D1859" /incds=0 /nref=26 /ntot=56 /MaxReadThrough="0.805200000000001" /MaxDrop="4.7199" /score="10.409416" /energy="-6.8" /TU="NA" /idTUdmin="U2817" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-35 complement(3359866..3359873) /Source="Nicolas_upshift_promotors" /id="U2819" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.603396603396603" /psig=1 /xcortree=1963 /SigmaFactorBS="aaaagaaagccccttttagcagggctttcttttTATTTGGCt cttttcctgattTTAGATAAAATAACATCAAAacagtaaaggtgtggtctgatgaaaa t" /listShort="ywrO" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3359912) /Source="Nicolas_upshifts" /id="D1860" /incds=0 /nref=20 /ntot=149 /MaxReadThrough="4.85403" /MaxDrop="6.46739" /score="-8.02974492" /energy="-5" /TU="U2821" /idTUdmin="U2821" /TUdmin="-616" /isTUend="FALSE" /label="downshifts" CDS complement(3359913..3360680) /gene="alsD" /locus_tag="BSU_36000" /old_locus_tag="BSU36000" /EC_number="4.1.1.5" /function="16.8: Protect" /function="16.14: Store" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7685336, 10972805, 12363365, 17183216, 21531833, 26454865" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7685336, 10972805, 12363365, 17183216, 21531833, 26454865; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="alpha-acetolactate decarboxylase" /protein_id="NP_391481.1" /db_xref="EnsemblGenomes-Gn:BSU36000" /db_xref="EnsemblGenomes-Tr:CAB15617" /db_xref="GOA:Q04777" /db_xref="InterPro:IPR005128" /db_xref="SubtiList:BG10472" /db_xref="UniProtKB/Swiss-Prot:Q04777" /translation="MKRESNIQVLSRGQKDQPVSQIYQVSTMTSLLDGVYDGDFELSE IPKYGDFGIGTFNKLDGELIGFDGEFYRLRSDGTATPVQNGDRSPFCSFTFFTPDMTH KIDAKMTREDFEKEINSMLPSRNLFYAIRIDGLFKKVQTRTVELQEKPYVPMVEAVKT QPIFNFDNVRGTIVGFLTPAYANGIAVSGYHLHFIDEGRNSGGHVFDYVLEDCTVTIS QKMNMNLRLPNTADFFNANLDNPDFAKDIETTEGSPE*" /label="alsD CDS" gene complement(3359913..3360680) /gene="alsD" /locus_tag="BSU_36000" /old_locus_tag="BSU36000" /label="alsD gene" CDS complement(3360742..3362454) /gene="alsS" /locus_tag="BSU_36010" /old_locus_tag="BSU36010" /EC_number="2.2.1.6" /function="16.8: Protect" /function="16.14: Store" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10972805, 12363365, 17183216, 7685336, 25393087, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10972805, 12363365, 17183216, 7685336, 25393087, 25355936; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="alpha-acetolactate synthase" /protein_id="NP_391482.2" /db_xref="EnsemblGenomes-Gn:BSU36010" /db_xref="EnsemblGenomes-Tr:CAB15618" /db_xref="GOA:Q04789" /db_xref="InterPro:IPR000399" /db_xref="InterPro:IPR011766" /db_xref="InterPro:IPR012000" /db_xref="InterPro:IPR012001" /db_xref="InterPro:IPR012782" /db_xref="InterPro:IPR029035" /db_xref="InterPro:IPR029061" /db_xref="SubtiList:BG10471" /db_xref="UniProtKB/Swiss-Prot:Q04789" /translation="MTKATKEQKSLVKNRGAELVVDCLVEQGVTHVFGIPGAKIDAVF DALQDKGPEIIVARHEQNAAFMAQAVGRLTGKPGVVLVTSGPGASNLATGLLTANTEG DPVVALAGNVIRADRLKRTHQSLDNAALFQPITKYSVEVQDVKNIPEAVTNAFRIASA GQAGAAFVSFPQDVVNEVTNTKNVRAVAAPKLGPAADDAISAAIAKIQTAKLPVVLVG MKGGRPEAIKAVRKLLKKVQLPFVETYQAAGTLSRDLEDQYFGRIGLFRNQPGDLLLE QADVVLTIGYDPIEYDPKFWNINGDRTIIHLDEIIADIDHAYQPDLELIGDIPSTINH IEHDAVKVEFAEREQKILSDLKQYMHEGEQVPADWKSDRAHPLEIVKELRNAVDDHVT VTCDIGSHAIWMSRYFRSYEPLTLMISNGMQTLGVALPWAIGASLVKPGEKVVSVSGD GGFLFSAMELETAVRLKAPIVHIVWNDSTYDMVAFQQLKKYNRTSAVDFGNIDIVKYA ESFGATGLRVESPDQLADVLRQGMNAEGPVIIDVPVDYSDNINLASDKLPKEFGELMK TKAL*" /label="alsS CDS" gene complement(3360742..3362454) /gene="alsS" /locus_tag="BSU_36010" /old_locus_tag="BSU36010" /label="alsS gene" promotor_-35 3361353..3361362 /Source="Nicolas_upshift_promotors" /id="U2820" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1377 /SigmaFactorBS="acgatttcaagagggtgcgctctgtctgatttccaatCTGCA GGCACctgctcaccttcaTGCATATATTGTTTTAAATCagaaaggattttctgctcac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3361376..3361395 /Source="Nicolas_upshift_promotors" /id="U2820" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1377 /SigmaFactorBS="acgatttcaagagggtgcgctctgtctgatttccaatCTGCA GGCACctgctcaccttcaTGCATATATTGTTTTAAATCagaaaggattttctgctcac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3361376 /Source="Nicolas_upshifts" /id="U2820" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1377 /SigmaFactorBS="acgatttcaagagggtgcgctctgtctgatttccaatCTGCA GGCACctgctcaccttcaTGCATATATTGTTTTAAATCagaaaggattttctgctcac g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3362508..3362527) /Source="Nicolas_upshift_promotors" /id="U2821" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.544455544455544" /psig="0.993006993006993" /xcortree=1577 /SigmaFactorBS="tacatattaatcataaggcgaatcgatATTGGaggtcaattt ccaaAGAGTGTATAGTGAAACTTAtcacaagatatttaaaattttacgtttaaaatgc a" /listShort="alsS, alsD, ywrO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3362513) /Source="Nicolas_upshifts" /id="U2821" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.544455544455544" /psig="0.993006993006993" /xcortree=1577 /SigmaFactorBS="tacatattaatcataaggcgaatcgatATTGGaggtcaattt ccaaAGAGTGTATAGTGAAACTTAtcacaagatatttaaaattttacgtttaaaatgc a" /listShort="alsS, alsD, ywrO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3362533..3362540 /Source="Nicolas_upshift_promotors" /id="U2822" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.498501498501498" /psig="0.985014985014985" /xcortree=99 /SigmaFactorBS="gtgataagtttcactatacactctttggaAATTGACCtccaa tatcgattCGCCTTATGATTAATATGTAatacgaattattaacctatggaaaggaatg c" /listShort="alsR, S1385" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(3362542..3362546) /Source="Nicolas_upshift_promotors" /id="U2821" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.544455544455544" /psig="0.993006993006993" /xcortree=1577 /SigmaFactorBS="tacatattaatcataaggcgaatcgatATTGGaggtcaattt ccaaAGAGTGTATAGTGAAACTTAtcacaagatatttaaaattttacgtttaaaatgc a" /listShort="alsS, alsD, ywrO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3362554..3362573 /Source="Nicolas_upshift_promotors" /id="U2822" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.498501498501498" /psig="0.985014985014985" /xcortree=99 /SigmaFactorBS="gtgataagtttcactatacactctttggaAATTGACCtccaa tatcgattCGCCTTATGATTAATATGTAatacgaattattaacctatggaaaggaatg c" /listShort="alsR, S1385" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3362564 /Source="Nicolas_upshifts" /id="U2822" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.498501498501498" /psig="0.985014985014985" /xcortree=99 /SigmaFactorBS="gtgataagtttcactatacactctttggaAATTGACCtccaa tatcgattCGCCTTATGATTAATATGTAatacgaattattaacctatggaaaggaatg c" /listShort="alsR, S1385" /GFF_Attribute="listLong" /label="upshifts" CDS 3362612..3363520 /gene="alsR" /locus_tag="BSU_36020" /old_locus_tag="BSU36020" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10809684, 10972805, 12363365, 15978075, 17183216, 7685336, 22178965, 23576037, 23695583, 23836140" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10809684, 10972805, 12363365, 15978075, 17183216, 7685336, 22178965, 23576037, 23695583, 23836140; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator controlling alsSD, ictEP expression (LysR family)" /protein_id="NP_391483.1" /db_xref="EnsemblGenomes-Gn:BSU36020" /db_xref="EnsemblGenomes-Tr:CAB15619" /db_xref="GOA:Q04778" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10470" /db_xref="UniProtKB/Swiss-Prot:Q04778" /translation="MELRHLQYFIAVAEELHFGKAARRLNMTQPPLSQQIKQLEEEVG VTLLKRTKRFVELTAAGEIFLNHCRMALMQIGQGIELAQRTARGEQGLLVIGFVGSAT YEFLPPIVREYRKKFPSVKIELREISSSRQQEELLKGNIDIGILHPPLQHTALHIETA QSSPCVLALPKQHPLTSKESITIEDLRDEPIITVAKEAWPTLYMDFIQFCEQAGFRPN IVQEATEYQMVIGLVSAGIGMTFVPSSAKKLFNLDVTYRKMDQIQLNAEWVIAYRKDN HNPLIKHFIHISNCQQTRTKESDAGT*" /label="alsR CDS" gene 3362612..3363520 /gene="alsR" /locus_tag="BSU_36020" /old_locus_tag="BSU36020" /label="alsR gene" promotor_-35 3363588..3363596 /Source="Nicolas_upshift_promotors" /id="U2823" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.896103896103896" /psig="0.896103896103896" /xcortree=1419 /SigmaFactorBS="ttttttcttttgggattcttatggaatttttattaatttaat ataatcgcTTAGTACAActttatatcagtaTACGTATACATACAGTACAAatagttgg c" /listShort="S1385, ywrK" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3363598..3363730 /Source="Nicolas_S_feature" /locus_tag="new_3712484_3712616" /HighExp="BT, S8, B36, S7, G/S, S6, Pyr, B60, Etha, Glucon" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.14666000000000001" /TUshortSig="SigK, SigA" /TUshortPSig="0.896, 0.985" /TUlongSig="NA" /TUlongPSig="NA" /label="S1385" upshifts 3363598 /Source="Nicolas_upshifts" /id="U2823" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.896103896103896" /psig="0.896103896103896" /xcortree=1419 /SigmaFactorBS="ttttttcttttgggattcttatggaatttttattaatttaat ataatcgcTTAGTACAActttatatcagtaTACGTATACATACAGTACAAatagttgg c" /listShort="S1385, ywrK" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3363610..3363629 /Source="Nicolas_upshift_promotors" /id="U2823" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.896103896103896" /psig="0.896103896103896" /xcortree=1419 /SigmaFactorBS="ttttttcttttgggattcttatggaatttttattaatttaat ataatcgcTTAGTACAActttatatcagtaTACGTATACATACAGTACAAatagttgg c" /listShort="S1385, ywrK" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3363731..3365059 /gene="ywrK" /locus_tag="BSU_36030" /old_locus_tag="BSU36030" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative Na+/H+ antiporter" /protein_id="NP_391484.1" /db_xref="EnsemblGenomes-Gn:BSU36030" /db_xref="EnsemblGenomes-Tr:CAB15620" /db_xref="GOA:O05224" /db_xref="InterPro:IPR000802" /db_xref="SubtiList:BG12527" /db_xref="UniProtKB/Swiss-Prot:O05224" /translation="MLAFFVTMIFIFWRPKGLNEAIPATFGALMVLLCGSVSLADLGE IGTKVTGASVTILATMIMAIALESFGFFYWVAAKLLQQSKGSGIKLFWLTNLLCFLMT IFLNNDGSILITTPILLLVLKYLGLKKHQKAPYLLSGVLIATASSAPIGVSNIVNLIS LKIIGMDLYLHTAMMFVPSMMGLIFMTCLLFMFFYKRLPKSLPDIPGHFQSLRHRRYH PLHSPSAPLPERNQTKIMLFVLAFVFLVRMSLFAASYTGISVPLVAVIGSFILLSWRW IYFKTSPRDLLYKSPWHIFIFAFTMYVLIYGLHNIGFTELLVSYFEPVVSGSLAHATF ASGISTSVFSNLFNNHPALMISTFTLTEMTLNPSTTKIIYLANIIGSDIGSLLLPMGT LATLIWMHILKQHDESISWGEYIKTTIIIIPLTVLFTLTCLYFWISWLFL*" /label="ywrK CDS" gene 3363731..3365059 /gene="ywrK" /locus_tag="BSU_36030" /old_locus_tag="BSU36030" /label="ywrK gene" downshifts 3365050 /Source="Nicolas_upshifts" /id="D1861" /incds=0 /nref=16 /ntot=32 /MaxReadThrough="1.63489" /MaxDrop="6.12455" /score="-6.14091334" /energy="-11.9" /TU="NA" /idTUdmin="U2823" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3365116..3365793) /gene="ywrJ" /locus_tag="BSU_36040" /old_locus_tag="BSU36040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 14762006, 22882546" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391485.1" /db_xref="EnsemblGenomes-Gn:BSU36040" /db_xref="EnsemblGenomes-Tr:CAB15621" /db_xref="InterPro:IPR020139" /db_xref="InterPro:IPR020173" /db_xref="SubtiList:BG12526" /db_xref="UniProtKB/Swiss-Prot:O05223" /translation="MKGLNQFLNTDVEVVISGDTRFVGTLIDIGQDIFVIFDGCNYLY IPLLHLHQINKAKIVTSTEKPFLINPEDPMIEAETQAFSYRNTLNKVKGQFIEVYVTG GRSIHGYVTNVLNDYIVFFSPVFKILFISMHHLKWFTPYSTEQTPYTLDNSQLPVVPS KVPLVRNFEEQIKKNIGELVIFDMGEVPEKVGLLKGVSNNIIELINASGEPVIWKLNH LKTMHLP*" /label="ywrJ CDS" gene complement(3365116..3365793) /gene="ywrJ" /locus_tag="BSU_36040" /old_locus_tag="BSU36040" /label="ywrJ gene" downshifts complement(3365126) /Source="Nicolas_upshifts" /id="D1862" /incds=0 /nref=14 /ntot=28 /MaxReadThrough="1.74629" /MaxDrop="5.1172" /score="-4.02447737" /energy="-9.5" /TU="NA" /idTUdmin="U2824" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3365853..3366995) /gene="cotB" /locus_tag="BSU_36050" /old_locus_tag="BSU36050" /function="16.8: Protect" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:8755863, 10559171, 11737650, 14762006, 19933362, 27185916" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8755863, 10559171, 11737650, 14762006, 19933362, 27185916; Product type s : structure" /codon_start=1 /transl_table=11 /product="spore coat protein (outer)" /protein_id="NP_391486.1" /db_xref="EnsemblGenomes-Gn:BSU36050" /db_xref="EnsemblGenomes-Tr:CAB15622" /db_xref="GOA:P07789" /db_xref="SubtiList:BG10491" /db_xref="UniProtKB/Swiss-Prot:P07789" /translation="MSKRRMKYHSNNEISYYNFLHSMKDKIVTVYRGGPESKKGKLTA VKSDYIALQAEKKIIYYQLEHVKSITEDTNNSTTTIETEEMLDADDFHSLIGHLINQS VQFNQGGPESKKGRLVWLGDDYAALNTNEDGVVYFNIHHIKSISKHEPDLKIEEQTPV GVLEADDLSEVFKSLTHKWVSINRGGPEAIEGILVDNADGHYTIVKNQEVLRIYPFHI KSISLGPKGSYKKEDQKNEQNQEDNNDKDSNSFISSKSYSSSKSSKRSLKSSDDQSSK SGRSSRSKSSSKSSKRSLKSSDYQSSKSGRSSRSKSSSKSSKRSLKSSDYQSSKSSKR SPRSSDYQSSRSPGYSSSIKSSGKQKEDYSYETIVRTIDYHWKRKF*" /label="cotB CDS" gene complement(3365853..3366995) /gene="cotB" /locus_tag="BSU_36050" /old_locus_tag="BSU36050" /label="cotB gene" promotor_-10 complement(3367032..3367051) /Source="Nicolas_upshift_promotors" /id="U2824" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.932067932067932" /psig="0.932067932067932" /xcortree=1302 /SigmaFactorBS="ggaaaaagcgacaattaggctattgaaTTAGTTCAAcaaata aatgtgaCACGTATATATGCAGTATGTttatcatctatgtataagtgactaggaggaa t" /listShort="cotB, ywrJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3367040) /Source="Nicolas_upshifts" /id="U2824" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.932067932067932" /psig="0.932067932067932" /xcortree=1302 /SigmaFactorBS="ggaaaaagcgacaattaggctattgaaTTAGTTCAAcaaata aatgtgaCACGTATATATGCAGTATGTttatcatctatgtataagtgactaggaggaa t" /listShort="cotB, ywrJ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3367042..3367122) /Source="Nicolas_S_feature" /locus_tag="new_3715928_3716008_c" /HighExp="S6, S7, S8, S5, BT, B36, S4, G/S, Pyr, S3" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigK" /TUshortPSig="0.142, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1386" promotor_-35 complement(3367065..3367073) /Source="Nicolas_upshift_promotors" /id="U2824" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.932067932067932" /psig="0.932067932067932" /xcortree=1302 /SigmaFactorBS="ggaaaaagcgacaattaggctattgaaTTAGTTCAAcaaata aatgtgaCACGTATATATGCAGTATGTttatcatctatgtataagtgactaggaggaa t" /listShort="cotB, ywrJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3367123..3368211) /gene="cotH" /locus_tag="BSU_36060" /old_locus_tag="BSU36060" /function="16.13: Shape" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:14762006, 25115591, 27185916" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14762006, 25115591, 27185916; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="spore coat protein kinase" /protein_id="NP_391487.1" /db_xref="EnsemblGenomes-Gn:BSU36060" /db_xref="EnsemblGenomes-Tr:CAB15623" /db_xref="GOA:Q45535" /db_xref="InterPro:IPR014867" /db_xref="SubtiList:BG11791" /db_xref="UniProtKB/Swiss-Prot:Q45535" /translation="MKNQSNLPLYQLFVHPKDLRELKKDIWDDDPVPAVMKVNQKRLD IDIAYRGSHIRDFKKKSYHISFYQPKTFRGAREIHLNAEYKDPSLMRNKLSLDFFSEL GTLSPKAEFAFVKMNGKNEGVYLELESVDEYYLAKRKLADGAIFYAVDDDANFSLMSD LERETKTSLELGYEKKTGTEEDDFYLQDMIFKINTVPKAQFKSEVTKHVDVDKYLRWL AGIVFTSNYDGFVHNYALYRSGETGLFEVIPWDYDATWGRDIHGERMAADYVRIQGFN TLTARILDESEFRKSYKRLLEKTLQSLFTIEYMEPKIMAMYERIRPFVLMDPYKKNDI ERFDREPDVICEYIKNRSQYLKDHLSIL*" /label="cotH CDS" gene complement(3367123..3368211) /gene="cotH" /locus_tag="BSU_36060" /old_locus_tag="BSU36060" /label="cotH gene" S_feature complement(3368212..3368325) /Source="Nicolas_S_feature" /locus_tag="new_3717098_3717211_c" /HighExp="S6, S8, S7, S5, BT, B36, Pyr, G/S, S4, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigK" /TUshortPSig="0.142, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1387" promotor_-35 3368267..3368276 /Source="Nicolas_upshift_promotors" /id="U2825" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1411 /SigmaFactorBS="tatttttataagatctcagcggaacACTTATACACtttttaa aaccgCGCGTACTATGAGGGTAGTAaggatcttcatccttaacatatttttaaaagga g" /listShort="cotG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3368289..3368308 /Source="Nicolas_upshift_promotors" /id="U2825" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1411 /SigmaFactorBS="tatttttataagatctcagcggaacACTTATACACtttttaa aaccgCGCGTACTATGAGGGTAGTAaggatcttcatccttaacatatttttaaaagga g" /listShort="cotG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3368302 /Source="Nicolas_upshifts" /id="U2825" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1411 /SigmaFactorBS="tatttttataagatctcagcggaacACTTATACACtttttaa aaccgCGCGTACTATGAGGGTAGTAaggatcttcatccttaacatatttttaaaagga g" /listShort="cotG" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(3368325) /Source="Nicolas_upshifts" /id="U2826" /multdbtbs="SigK" /comp="M15" /sig="Sig-" /pcomp="0.817182817182817" /psig="0.141858141858142" /xcortree=1262 /SigmaFactorBS="cttcttcgatgtcagaatgggaatagtggCCCAAtttgaaat CCTCCTTTTAAAAATatgttaaggatgaagatccttactaccctcatagtacgcgcgg t" /listShort="S1387, cotH, S1386, cotB, ywrJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3368329..3368343) /Source="Nicolas_upshift_promotors" /id="U2826" /multdbtbs="SigK" /comp="M15" /sig="Sig-" /pcomp="0.817182817182817" /psig="0.141858141858142" /xcortree=1262 /SigmaFactorBS="cttcttcgatgtcagaatgggaatagtggCCCAAtttgaaat CCTCCTTTTAAAAATatgttaaggatgaagatccttactaccctcatagtacgcgcgg t" /listShort="S1387, cotH, S1386, cotB, ywrJ" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3368352..3368356) /Source="Nicolas_upshift_promotors" /id="U2826" /multdbtbs="SigK" /comp="M15" /sig="Sig-" /pcomp="0.817182817182817" /psig="0.141858141858142" /xcortree=1262 /SigmaFactorBS="cttcttcgatgtcagaatgggaatagtggCCCAAtttgaaat CCTCCTTTTAAAAATatgttaaggatgaagatccttactaccctcatagtacgcgcgg t" /listShort="S1387, cotH, S1386, cotB, ywrJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3368352..3368939 /gene="cotG" /locus_tag="BSU_36070" /old_locus_tag="BSU36070" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11737650, 14762006, 15621419, 22720735, 25115591, 27185916" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11737650, 14762006, 15621419, 22720735, 25115591, 27185916; Product type cp : cell process" /codon_start=1 /transl_table=11 /product="spore morphogenetic protein" /protein_id="NP_391488.1" /db_xref="EnsemblGenomes-Gn:BSU36070" /db_xref="EnsemblGenomes-Tr:CAB15624" /db_xref="GOA:P39801" /db_xref="SubtiList:BG11017" /db_xref="UniProtKB/Swiss-Prot:P39801" /translation="MGHYSHSDIEEAVKSAKKEGLKDYLYQEPHGKKRSHKKSHRTHK KSRSHKKSYCSHKKSRSHKKSFCSHKKSRSHKKSYCSHKKSRSHKKSYRSHKKSRSYK KSYRSYKKSRSYKKSCRSYKKSRSYKKSYCSHKKKSRSYKKSCRTHKKSYRSHKKYYK KPHHHCDDYKRHDDYDSKKEYWKDGNCWVVKKKYK*" /label="cotG CDS" gene 3368352..3368939 /gene="cotG" /locus_tag="BSU_36070" /old_locus_tag="BSU36070" /label="cotG gene" CDS 3368440..3368919 /locus_tag="BSU_36079" /old_locus_tag="BSU36079" /function="14.1: Surface structures" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="doubtful CDS (putative in frame frameshift)" /protein_id="YP_009514005.1" /translation="MEKNAVIKSRTALTKNLAAIKNHTALTKNLAVTKNHSVLTKNLA ATKNHTALTRNLAATKNRTVLTKNLAAIKNLTVLTKNLVAIKNLAVLTKNLAATKSLT VLTRKNLAAIRSHAAHTKNLIVPIRNTTKNRTTTATTTKDTMIMTAKKNTGKTAIAG* " /label="doubtful CDS (putative in frame frameshift)" gene 3368440..3368919 /locus_tag="BSU_36079" /old_locus_tag="BSU36079" /label="gene" S_feature complement(3368823..3369020) /Source="Nicolas_S_feature" /locus_tag="new_3717709_3717906_c" /HighExp="S5, S6, S4, B60, S3, nit, G/S, SMMPr, S8, ferm" /AntisenseName="cotG" /AntisenseCor="0.60092819988141299" /AntisenseRegPval="-27.1" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1388" downshifts 3368856 /Source="Nicolas_upshifts" /id="D1863" /incds=1 /nref=1 /ntot=54 /MaxReadThrough="7.80801" /MaxDrop="2.7794" /score="17.1895651" /energy="-10.7" /TU="U2825" /idTUdmin="U2825" /TUdmin="-154" /isTUend="FALSE" /label="downshifts" downshifts complement(3368866) /Source="Nicolas_upshifts" /id="D1864" /incds=1 /nref=3 /ntot=23 /MaxReadThrough="4.99409" /MaxDrop="6.67733" /score="-1.37249416" /energy="-5.2" /TU="U2827" /idTUdmin="U2824" /TUdmin="-3740" /isTUend="FALSE" /label="downshifts" downshifts 3368925 /Source="Nicolas_upshifts" /id="D1865" /incds=0 /nref=41 /ntot=80 /MaxReadThrough="4.68169" /MaxDrop="5.35584" /score="17.1895651" /energy="-10.7" /TU="U2825" /idTUdmin="U2825" /TUdmin="-85" /isTUend="FALSE" /label="downshifts" downshifts 3369004 /Source="Nicolas_upshifts" /id="D1866" /incds=0 /nref=4 /ntot=17 /MaxReadThrough="2.30708" /MaxDrop="3.92552" /score="17.1895651" /energy="-10.7" /TU="NA" /idTUdmin="U2825" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3369019..3369038) /Source="Nicolas_upshift_promotors" /id="U2827" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1268 /SigmaFactorBS="accttgattataacgaaatggtttaAAGGAAACCAaatgatg cgggtTGCATATGTTATGTCATGACatatatctaatacagggcaaataaaaaaatagg c" /listShort="S1388, S1387, cotH, S1386, cotB, ywrJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3369025) /Source="Nicolas_upshifts" /id="U2827" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1268 /SigmaFactorBS="accttgattataacgaaatggtttaAAGGAAACCAaatgatg cgggtTGCATATGTTATGTCATGACatatatctaatacagggcaaataaaaaaatagg c" /listShort="S1388, S1387, cotH, S1386, cotB, ywrJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3369047..3369054 /Source="Nicolas_upshift_promotors" /id="U2828" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=1941 /SigmaFactorBS="atatgtcatgacataacatatgcaacccgcatCATTTGGTtt cctttaaaccatTTCGTTATAATCAAGGTATCctaacgataaaggcggttgttgctat g" /listShort="ywrF, S1389, ywrE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(3369051..3369060) /Source="Nicolas_upshift_promotors" /id="U2827" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1268 /SigmaFactorBS="accttgattataacgaaatggtttaAAGGAAACCAaatgatg cgggtTGCATATGTTATGTCATGACatatatctaatacagggcaaataaaaaaatagg c" /listShort="S1388, S1387, cotH, S1386, cotB, ywrJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3369069..3369088 /Source="Nicolas_upshift_promotors" /id="U2828" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=1941 /SigmaFactorBS="atatgtcatgacataacatatgcaacccgcatCATTTGGTtt cctttaaaccatTTCGTTATAATCAAGGTATCctaacgataaaggcggttgttgctat g" /listShort="ywrF, S1389, ywrE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3369075 /Source="Nicolas_upshifts" /id="U2828" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=1941 /SigmaFactorBS="atatgtcatgacataacatatgcaacccgcatCATTTGGTtt cctttaaaccatTTCGTTATAATCAAGGTATCctaacgataaaggcggttgttgctat g" /listShort="ywrF, S1389, ywrE" /GFF_Attribute="listLong" /label="upshifts" CDS 3369113..3369730 /gene="ywrF" /locus_tag="BSU_36080" /old_locus_tag="BSU36080" /EC_number="1.14.13.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative flavin-binding monooxygenase" /protein_id="NP_391489.1" /db_xref="EnsemblGenomes-Gn:BSU36080" /db_xref="EnsemblGenomes-Tr:CAB15625" /db_xref="GOA:O05220" /db_xref="InterPro:IPR002563" /db_xref="InterPro:IPR012349" /db_xref="SubtiList:BG12525" /db_xref="UniProtKB/Swiss-Prot:O05220" /translation="MYIFQADQLSAKDTYKLLSGTVIPRPIAFVTTLSSGGAVNAAPF SFYNVVSSDPPLLSISVNRTEGRQKDTARNAVENGEFVVHVSDEAIIEDINETAASLR PDESELTRTSLHPVESKAVSVPGIKEARVRFECKLERHITFDNDQGITTADLLIGRVV CFHLDEKVYDAEKGYILTDELKPASRLAGNHYAKLGEEFTLIRPS*" /label="ywrF CDS" gene 3369113..3369730 /gene="ywrF" /locus_tag="BSU_36080" /old_locus_tag="BSU36080" /label="ywrF gene" S_feature 3369731..3369831 /Source="Nicolas_S_feature" /locus_tag="new_3718617_3718717" /HighExp="Etha, dia5, Diami, dia15, Lbtran, LBGtran, LPhT, M40t45, M40t90, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1389" downshifts 3369788 /Source="Nicolas_upshifts" /id="D1867" /incds=0 /nref=11 /ntot=56 /MaxReadThrough="4.52989" /MaxDrop="4.48979" /score="-1.9002322" /energy="-14.9" /TU="U2828" /idTUdmin="U2828" /TUdmin="-454" /isTUend="FALSE" /label="downshifts" promotor_-35 3369857..3369866 /Source="Nicolas_upshift_promotors" /id="U2829" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1701 /SigmaFactorBS="aaaaagaacacccagagcaagctcggggtgttcttttaTGAA ACGTTTttcctttttctTCGTATAAAGGTAGATtaggaggaattggaatgacaaactt t" /listShort="ywrE, S1390, ywrC, ywrB, ywrA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3369878..3369893 /Source="Nicolas_upshift_promotors" /id="U2829" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1701 /SigmaFactorBS="aaaaagaacacccagagcaagctcggggtgttcttttaTGAA ACGTTTttcctttttctTCGTATAAAGGTAGATtaggaggaattggaatgacaaactt t" /listShort="ywrE, S1390, ywrC, ywrB, ywrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3369879 /Source="Nicolas_upshifts" /id="U2829" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1701 /SigmaFactorBS="aaaaagaacacccagagcaagctcggggtgttcttttaTGAA ACGTTTttcctttttctTCGTATAAAGGTAGATtaggaggaattggaatgacaaactt t" /listShort="ywrE, S1390, ywrC, ywrB, ywrA" /GFF_Attribute="listLong" /label="upshifts" CDS 3369908..3370243 /gene="ywrE" /locus_tag="BSU_36090" /old_locus_tag="BSU36090" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391490.1" /db_xref="EnsemblGenomes-Gn:BSU36090" /db_xref="EnsemblGenomes-Tr:CAB15626" /db_xref="GOA:O05219" /db_xref="InterPro:IPR025441" /db_xref="SubtiList:BG12524" /db_xref="UniProtKB/Swiss-Prot:O05219" /translation="MTNFWILMLIAITISLASQFFIKKKYGIDKSGWRYKHVSNTHKW IEITLLILFVFSLSFFPVEYLLLLFFIVIDSIRIFMEWHYRPEDKQYMYHIVEVSLMF MLLIYVCTL*" /label="ywrE CDS" gene 3369908..3370243 /gene="ywrE" /locus_tag="BSU_36090" /old_locus_tag="BSU36090" /label="ywrE gene" promotor_-10 complement(3370199..3370217) /Source="Nicolas_upshift_promotors" /id="U2830" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1203 /SigmaFactorBS="ggagcggctgtggggatttaaataactatagGGTACAaacat aaatcaaaaGCATAAACATAAGGGAGACctctacaatgtggtacatatactgtttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3370208) /Source="Nicolas_upshifts" /id="U2830" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1203 /SigmaFactorBS="ggagcggctgtggggatttaaataactatagGGTACAaacat aaatcaaaaGCATAAACATAAGGGAGACctctacaatgtggtacatatactgtttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3370232..3370237) /Source="Nicolas_upshift_promotors" /id="U2830" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.984015984015984" /psig="0.984015984015984" /xcortree=1203 /SigmaFactorBS="ggagcggctgtggggatttaaataactatagGGTACAaacat aaatcaaaaGCATAAACATAAGGGAGACctctacaatgtggtacatatactgtttatc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3370242 /Source="Nicolas_upshifts" /id="D1868" /incds=0 /nref=5 /ntot=153 /MaxReadThrough="5.64855" /MaxDrop="3.64569" /score="-1.9002322" /energy="-14.9" /TU="U2829" /idTUdmin="U2828" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3370248..3371825) /gene="hpxW" /locus_tag="BSU_36100" /old_locus_tag="BSU36100" /EC_number="3.5.1.126" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12823818, 14762019, 19935659, 27303801, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="oxamate amidohydrolase" /protein_id="NP_391491.1" /db_xref="EnsemblGenomes-Gn:BSU36100" /db_xref="EnsemblGenomes-Tr:CAB15627" /db_xref="GOA:O05218" /db_xref="InterPro:IPR000101" /db_xref="InterPro:IPR029055" /db_xref="SubtiList:BG12523" /db_xref="UniProtKB/Swiss-Prot:O05218" /translation="MNKSVIGTKQMVVSPHYLASQAGNRILDKGGNAFDAAVAVSACL AVVYPHMTGLGGDSFWLTFHQETKAVKVYNGSGRSGKNVTRDVYKGKSAIPLRGIDSA ITVPGMVDSWDAVLKEYGRLSLADVLEPARDYAQNGFPVSADQCRHTEKNIELLASTP YTADIFTRRGKAPVPGERFVQKELADSLNLIAEKGRSAFYEGDLAQRIVSHLQNNGSY MTIDDFKAHRGEWAAPVSSDYRGYSVYQAPPNSQGFTGLLTLNILENYDFTQIEHGSF EYYHVLVEALKKSFLDRDAVLTDPAFADIPLERLLDKRYAKQLAEEIGYLAIPAESRP VGSDTAYAAVIDADGNAVSFIQSLYFEFGSAVTAGDTGILLQNRGSFFSLDENHVNTL EPRKRTFHTLMPAMVCKGGKPKILYGTQGGEGQPQTQTAIITRMLDYGMHPQQAISEP RWVWGRTWGEEYEGLRVEGRFTDKTIQKLKDSGHLVEVVGDYDPLMGQAAAIKVDEEG FLQGGADPRGDGAAVGI*" /label="hpxW CDS" gene complement(3370248..3371825) /gene="hpxW" /locus_tag="BSU_36100" /old_locus_tag="BSU36100" /label="hpxW gene" S_feature 3370287..3371998 /Source="Nicolas_S_feature" /locus_tag="new_3719173_3720884" /HighExp="T1.0H, T0.30H, T1.30H, T2.0H, T2.30H, T3.30H, T3.0H, T-0.40H, T0.0H, Salt" /AntisenseName="ywrD" /AntisenseCor="0.153519829066777" /AntisenseRegPval="-1.9" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1390" promotor_-35 3371976..3371983 /Source="Nicolas_upshift_promotors" /id="U2831" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.896103896103896" /psig=1 /xcortree=2447 /SigmaFactorBS="tttcgcattcatttcgaaaacaaatgaaaaattattATTTCT ATacgtaactttTATGATAAAATGATTGCTAAaaggctacgaaagcaggtggagcaat t" /listShort="ywrC, ywrB, ywrA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3371994..3372013 /Source="Nicolas_upshift_promotors" /id="U2831" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.896103896103896" /psig=1 /xcortree=2447 /SigmaFactorBS="tttcgcattcatttcgaaaacaaatgaaaaattattATTTCT ATacgtaactttTATGATAAAATGATTGCTAAaaggctacgaaagcaggtggagcaat t" /listShort="ywrC, ywrB, ywrA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3372000 /Source="Nicolas_upshifts" /id="U2831" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.896103896103896" /psig=1 /xcortree=2447 /SigmaFactorBS="tttcgcattcatttcgaaaacaaatgaaaaattattATTTCT ATacgtaactttTATGATAAAATGATTGCTAAaaggctacgaaagcaggtggagcaat t" /listShort="ywrC, ywrB, ywrA" /GFF_Attribute="listLong" /label="upshifts" CDS 3372039..3372515 /gene="chrS" /locus_tag="BSU_36110" /old_locus_tag="BSU36110" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:23989926" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23989926; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional negative regulator of chromate transport (Lrp/AsnC family)" /protein_id="NP_391492.1" /db_xref="EnsemblGenomes-Gn:BSU36110" /db_xref="EnsemblGenomes-Tr:CAB15628" /db_xref="GOA:O05217" /db_xref="InterPro:IPR000485" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR019887" /db_xref="InterPro:IPR019888" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12522" /db_xref="UniProtKB/Swiss-Prot:O05217" /translation="MSHEYQIPNLVLDETDKQILTILHEEGRISYTDLGKRVDLSRVA VQARINQLIEAGVIEKFTAVINPAKIGIHVSVFFNVEVEPQFLEEVALKLEEEPAVTS LYHMTGPSKLHMHGIFTNDQEMEEFLTKRLYPLRGVVSVDCQMLIKRYKSRMGMKL*" /label="chrS CDS" gene 3372039..3372515 /gene="chrS" /locus_tag="BSU_36110" /old_locus_tag="BSU36110" /label="chrS gene" CDS 3372529..3373122 /gene="chrB" /locus_tag="BSU_36120" /old_locus_tag="BSU36120" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 23989926" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 23989926; Product type t: transporter" /codon_start=1 /transl_table=11 /product="chromate transporter subunit N" /protein_id="NP_391493.1" /db_xref="EnsemblGenomes-Gn:BSU36120" /db_xref="EnsemblGenomes-Tr:CAB15629" /db_xref="GOA:O05216" /db_xref="InterPro:IPR003370" /db_xref="SubtiList:BG12521" /db_xref="UniProtKB/Swiss-Prot:O05216" /translation="MKNHPYRDMTAAMVRTGILGFGGGPSVIPLIRHEAVNKYKWIDD DEFGEILAIANALPGPIATKMAAYLGFKLKGTLGAIVAILAHILPTCLAMVGLFAAVN VLSHSAIVAGMIGAVTPVIAVMLGIMAYEFGQKALKGFGWVTGILFFIIAFIGLQTLQ INPGLVIIIFLAYGAFHFKLKDKITNKHSKDKGMSAS*" /label="chrB CDS" gene 3372529..3373122 /gene="chrB" /locus_tag="BSU_36120" /old_locus_tag="BSU36120" /label="chrB gene" CDS 3373119..3373655 /gene="chrA" /locus_tag="BSU_36130" /old_locus_tag="BSU36130" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 23989926" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 23989926; Product type t: transporter" /codon_start=1 /transl_table=11 /product="chromate transporter subunit C" /protein_id="NP_391494.1" /db_xref="EnsemblGenomes-Gn:BSU36130" /db_xref="EnsemblGenomes-Tr:CAB15630" /db_xref="GOA:O05215" /db_xref="InterPro:IPR003370" /db_xref="SubtiList:BG12520" /db_xref="UniProtKB/Swiss-Prot:O05215" /translation="MISIYLFMAFFIANLLGYGGGPASIPLMFEEVVNRYSWLSNDQF SNMLALANALPGPIATKIAAYVGYSAGGWPGFLIALIATVVPSALALIVLLRIIQRFR QSPVIKGMTLSVQPVIAVMMLILTWQIGADGIKAIGWVQSIVITGISLLAMTKFKMHP AFLIIAAFLYGGLVIPYL*" /label="chrA CDS" gene 3373119..3373655 /gene="chrA" /locus_tag="BSU_36130" /old_locus_tag="BSU36130" /label="chrA gene" downshifts 3373636 /Source="Nicolas_upshifts" /id="D1869" /incds=0 /nref=4 /ntot=90 /MaxReadThrough="0.0513700000000004" /MaxDrop="3.46649" /score="29.5508265" /energy="-8.6" /TU="NA" /idTUdmin="U2829" /TUdmin=28 /isTUend="FALSE" /label="downshifts" CDS complement(3373682..3373903) /gene="ywqO" /locus_tag="BSU_36140" /old_locus_tag="BSU36140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391495.1" /db_xref="EnsemblGenomes-Gn:BSU36140" /db_xref="EnsemblGenomes-Tr:CAB15631" /db_xref="SubtiList:BG12519" /db_xref="UniProtKB/Swiss-Prot:P96727" /translation="MKFLLSVIAGLLILALYLFWKVQPPVWIQVETNSSQLKQSVRMA GTTLQVKHMIKSDAGEETAVISNGISGLK*" /label="ywqO CDS" gene complement(3373682..3373903) /gene="ywqO" /locus_tag="BSU_36140" /old_locus_tag="BSU36140" /label="ywqO gene" upshifts 3373850 /Source="Nicolas_upshifts" /id="U2832" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.297702297702298" /psig="0.447552447552448" /xcortree=1475 /SigmaFactorBS="cttcaactgggacgaattggtttcaacttgtatccaaacagg aggctggaccttccaaaataaatagAGtgcaagaatcagcaagccagcaatgaccgac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 3373857..3373858 /Source="Nicolas_upshift_promotors" /id="U2832" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.297702297702298" /psig="0.447552447552448" /xcortree=1475 /SigmaFactorBS="cttcaactgggacgaattggtttcaacttgtatccaaacagg aggctggaccttccaaaataaatagAGtgcaagaatcagcaagccagcaatgaccgac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(3373900..3374445) /gene="ywqN" /locus_tag="BSU_36150" /old_locus_tag="BSU36150" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391496.1" /db_xref="EnsemblGenomes-Gn:BSU36150" /db_xref="EnsemblGenomes-Tr:CAB15632" /db_xref="GOA:P96726" /db_xref="InterPro:IPR005025" /db_xref="InterPro:IPR029039" /db_xref="PDB:1RLI" /db_xref="SubtiList:BG12518" /db_xref="UniProtKB/Swiss-Prot:P96726" /translation="MKIAVINGGTRSGGNTDVLAEKAVQGFDAEHIYLQKYPIQPIED LRHAQGGFRPVQDDYDSIIERILQCHILIFATPIYWFGMSGTLKLFIDRWSQTLRDPR FPDFKQQMSVKQAYVIAVGGDNPKIKGLPLIQQFEHIFHFMGMSFKGYVLGEGNRPGD ILRDHQALSAASRLLKRSDAI*" /label="ywqN CDS" gene complement(3373900..3374445) /gene="ywqN" /locus_tag="BSU_36150" /old_locus_tag="BSU36150" /label="ywqN gene" promotor_-35 3374462..3374469 /Source="Nicolas_upshift_promotors" /id="U2833" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig="0.996003996003996" /xcortree=1866 /SigmaFactorBS="aataaccgcaattttcatgatgcatctgctccttTGTTTACG aatgattttcttcaTCATATAATGGATTCATCAAtcaatacagatgattatttcgatt a" /listShort="ywqM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3374484..3374503 /Source="Nicolas_upshift_promotors" /id="U2833" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig="0.996003996003996" /xcortree=1866 /SigmaFactorBS="aataaccgcaattttcatgatgcatctgctccttTGTTTACG aatgattttcttcaTCATATAATGGATTCATCAAtcaatacagatgattatttcgatt a" /listShort="ywqM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3374488 /Source="Nicolas_upshifts" /id="U2833" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.756243756243756" /psig="0.996003996003996" /xcortree=1866 /SigmaFactorBS="aataaccgcaattttcatgatgcatctgctccttTGTTTACG aatgattttcttcaTCATATAATGGATTCATCAAtcaatacagatgattatttcgatt a" /listShort="ywqM" /GFF_Attribute="listLong" /label="upshifts" CDS 3374568..3375449 /gene="ywqM" /locus_tag="BSU_36160" /old_locus_tag="BSU36160" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (LysR family)" /protein_id="NP_391497.1" /db_xref="EnsemblGenomes-Gn:BSU36160" /db_xref="EnsemblGenomes-Tr:CAB15633" /db_xref="GOA:P96725" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12517" /db_xref="UniProtKB/Swiss-Prot:P96725" /translation="MELKQLITFITAAEHVNFTLTAKMLNYAQSSVTSQIKSLEEEIG TPLFERLGKRLILTEAGKTFKSYAQKIIALTEEAKMATNQVRETTGTLKIGATESQCT YRLPPIIKEFKQAFPQVKLIFKPYISNEQAKEQLLQGQLDITFILDVNRMEDALHVES LIQDEIKMVAANDHPFPADLPVTLKDLQNETLLLTEDGCSYRTLFENNLHDSGIYPNK LEFVSIEAIKQCVMAGLGIGILPEMTVKDDIAAGRMKELNWQSDCPVFTQLAWHKDKW MSAPLKAFIDLTRKTFK*" /label="ywqM CDS" gene 3374568..3375449 /gene="ywqM" /locus_tag="BSU_36160" /old_locus_tag="BSU36160" /label="ywqM gene" CDS complement(3375534..3376250) /gene="nfi" /locus_tag="BSU_36170" /old_locus_tag="BSU36170" /EC_number="3.1.21.7" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1692969, 22056936, 27530626" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1692969, 22056936, 27530626; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endonuclease V" /protein_id="NP_391498.2" /db_xref="EnsemblGenomes-Gn:BSU36170" /db_xref="EnsemblGenomes-Tr:CAB15634" /db_xref="GOA:P96724" /db_xref="InterPro:IPR007581" /db_xref="PDB:3GA2" /db_xref="SubtiList:BG12516" /db_xref="UniProtKB/Swiss-Prot:P96724" /translation="MKVFDVHKFDMKKEQDFLQVQFNLKNRINLSPTIHPDSINTCAG VDLAYWEQDGEPYGVCCIIVIDADTKEVIEKVHSMGRISVPYVSGFLAFRELPLIIEA AKKLETEPDVFLFDGNGYLHYNHMGVATHAAFFLGKPTIGIAKTYLKIKGCDFVTPEI EVGAYTDIIIDGEVYGRALRTRRDVKPIFLSCGNYIDLDSSYQITMSLINQESRLPIP VRLADLETHVLRTFYQKNHV*" /label="nfi CDS" gene complement(3375534..3376250) /gene="nfi" /locus_tag="BSU_36170" /old_locus_tag="BSU36170" /label="nfi gene" downshifts complement(3375554) /Source="Nicolas_upshifts" /id="D1870" /incds=0 /nref=44 /ntot=216 /MaxReadThrough="1.91774" /MaxDrop="3.62442" /score="12.1019223" /energy="-7.4" /TU="NA" /idTUdmin="U2834" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3376260..3376724) /gene="rttO" /locus_tag="BSU_36180" /old_locus_tag="BSU36180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22200572; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ribonuclease antitoxin" /protein_id="NP_391499.1" /db_xref="EnsemblGenomes-Gn:BSU36180" /db_xref="EnsemblGenomes-Tr:CAB15635" /db_xref="InterPro:IPR011652" /db_xref="SubtiList:BG12515" /db_xref="UniProtKB/Swiss-Prot:P96723" /translation="MENEYDMKSIKEKGVDFEDLWFSSVSDEILDNPEDENGQPFTGL AYELYPNGQIIYFTKYKNGLAHGLTCEFYENGNKKSEKEYRYGQLHGISIIWFENGRK KSEQQYEHSILISEKNWDEEGNLLNKYEIDTDSPHFEILESRRETHINLGRE*" /label="rttO CDS" gene complement(3376260..3376724) /gene="rttO" /locus_tag="BSU_36180" /old_locus_tag="BSU36180" /label="rttO gene" CDS complement(3376714..3378522) /gene="rttN" /locus_tag="BSU_36190" /old_locus_tag="BSU36190" /EC_number="3.1.-.-" /function="15.8: Toxin production and resistance" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22200572; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ribonuclease toxin" /protein_id="NP_391500.1" /db_xref="EnsemblGenomes-Gn:BSU36190" /db_xref="EnsemblGenomes-Tr:CAB15636" /db_xref="GOA:P96722" /db_xref="InterPro:IPR006829" /db_xref="InterPro:IPR025968" /db_xref="InterPro:IPR027797" /db_xref="SubtiList:BG12514" /db_xref="UniProtKB/Swiss-Prot:P96722" /translation="MSKVFESKSLIEEAKSRKKQYETLEEQLNTLKKAFQGVADLGDN FKGNGADNIKDFFQGQAEIVDSWLTLVSAQIAFLNGISGDIKDQELNDSYVETSFLDH ELPNGDLKASEIVSAHKEEIDSILSGISDIIDLDMYTLDDYADKMGDAQKIRRDTITA VDKLDESLTTEYQNLESLDNAVLTKYSVLMQATSNGKSASPMYYDKKAFHSNEVYKSV IEVENQGTTYIDAKTQQAEARRLQEKAEEEANKPWYEKTWDGVCNFTGEVTGYYDYKR ATEGVDPVTGEKLSTAERVTAGAMAAAGFIPVVGWAGRAFKGGKAIYKTGKAAIAAEH ALDAYKTGKSLDILKMTEMGAYGLVASNGFSEAVTGRDMFGNKVSEEKRKQGALEAIT IIGGAGLAHYFDRLYQKNAPYVNKVSNESLISNIAKTTEEKQTRLQYLRNKHGVLSKE DLHHRINLRAEVLNELSRIKSSGLTKKQRGPAVAGVLDKKTGNYYFGINNIDGKPPKV LHPLIHDRIVNMPTELKEGYIKTSGAGSHAEVNALNEALLQRPDADLKDLMVYVVSAR KINKKMPEGVPMPRCPHCEYITQNTNYIPEALKYGK*" /label="rttN CDS" gene complement(3376714..3378522) /gene="rttN" /locus_tag="BSU_36190" /old_locus_tag="BSU36190" /label="rttN gene" CDS complement(3378541..3378801) /gene="ywqI" /locus_tag="BSU_36200" /old_locus_tag="BSU36200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391501.1" /db_xref="EnsemblGenomes-Gn:BSU36200" /db_xref="EnsemblGenomes-Tr:CAB15637" /db_xref="InterPro:IPR020299" /db_xref="SubtiList:BG12513" /db_xref="UniProtKB/Swiss-Prot:P96721" /translation="MSEIKLKYDTVIKTLDSVKDALADVSIGAAGSNGKNSLDYTKKY HEREENIKTMLGDYKKAVQKNIEDTKDNVDSLKEQDEAIAVK*" /label="ywqI CDS" gene complement(3378541..3378801) /gene="ywqI" /locus_tag="BSU_36200" /old_locus_tag="BSU36200" /label="ywqI gene" CDS complement(3378811..3379233) /gene="ywqH" /locus_tag="BSU_36210" /old_locus_tag="BSU36210" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15101989" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391502.1" /db_xref="EnsemblGenomes-Gn:BSU36210" /db_xref="EnsemblGenomes-Tr:CAB15638" /db_xref="InterPro:IPR020326" /db_xref="InterPro:IPR031681" /db_xref="SubtiList:BG12512" /db_xref="UniProtKB/Swiss-Prot:P96720" /translation="MGYESMLADIKSSLNGKISDVEDKIEKLKKAKKDIDTLQEEAIT EIKEIVKPELGKHWTGTKADDFDKGREEAKSEASKIVNDKYNEYMASINGKIFDLEWD KAKYASELFIANGAADLLKKGEEFAEEVGNTISKLKWW*" /label="ywqH CDS" gene complement(3378811..3379233) /gene="ywqH" /locus_tag="BSU_36210" /old_locus_tag="BSU36210" /label="ywqH gene" S_feature complement(3379234..3379316) /Source="Nicolas_S_feature" /locus_tag="new_3728120_3728202_c" /HighExp="T2.30H, T4.0H, T5.0H, T3.0H, T3.30H, T1.30H, T2.0H, S4, T-0.40H, S2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1391" promotor_-10 complement(3379308..3379327) /Source="Nicolas_upshift_promotors" /id="U2834" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.486513486513487" /psig="0.996003996003996" /xcortree=2973 /SigmaFactorBS="gttatatgcctaaattaagccatttacccTATTTAAGccgcc ttctggcTATTTTAAAATATAATATATggaaataaagtatggaaaagtctatcttcat c" /listShort="S1391, ywqH, ywqI, ywqJ, ywqK, ywqL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3379316) /Source="Nicolas_upshifts" /id="U2834" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.486513486513487" /psig="0.996003996003996" /xcortree=2973 /SigmaFactorBS="gttatatgcctaaattaagccatttacccTATTTAAGccgcc ttctggcTATTTTAAAATATAATATATggaaataaagtatggaaaagtctatcttcat c" /listShort="S1391, ywqH, ywqI, ywqJ, ywqK, ywqL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3379340..3379347) /Source="Nicolas_upshift_promotors" /id="U2834" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.486513486513487" /psig="0.996003996003996" /xcortree=2973 /SigmaFactorBS="gttatatgcctaaattaagccatttacccTATTTAAGccgcc ttctggcTATTTTAAAATATAATATATggaaataaagtatggaaaagtctatcttcat c" /listShort="S1391, ywqH, ywqI, ywqJ, ywqK, ywqL" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3379450..3379575) /locus_tag="BSU_36215" /old_locus_tag="BSU36215" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514006.1" /translation="MTKSDMADQMKNINMNNKLSAERGRSTTSASFKCLYNYDIR*" /label="hypothetical protein CDS" gene complement(3379450..3379575) /locus_tag="BSU_36215" /old_locus_tag="BSU36215" /label="gene" S_feature complement(3379493..3379624) /Source="Nicolas_S_feature" /locus_tag="new_3728379_3728510_c" /HighExp="HiOs, BI, M9-tran, T-2.40H, MG 150, Sw, M9-exp, S1, T-3.40H, T-4.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.19133600000000001" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1392" downshifts complement(3379536) /Source="Nicolas_upshifts" /id="D1871" /incds=0 /nref=29 /ntot=208 /MaxReadThrough="3.03928" /MaxDrop="3.47153" /score="16.9931891" /energy="-8.4" /TU="NA" /idTUdmin="U2835" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3379625..3380410) /gene="ywqG" /locus_tag="BSU_36220" /old_locus_tag="BSU36220" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391503.1" /db_xref="EnsemblGenomes-Gn:BSU36220" /db_xref="EnsemblGenomes-Tr:CAB15639" /db_xref="InterPro:IPR015315" /db_xref="InterPro:IPR035948" /db_xref="PDB:1PV5" /db_xref="SubtiList:BG12511" /db_xref="UniProtKB/Swiss-Prot:P96719" /translation="MNHLPEKMRPYRDLLEKSAKEYVKLNVRKGKTGRYDSKIAGDPY FPKHETYPTDENGQPMKLLAQINFSHIPQLDGYPSSGILQFYISVHDDVYGLNFDDRC EQKNFRVIYFENIVENDDELVSDFSFIGTGECDFPILSEAAVEPVKSSEWVLPTDFQF EQYTGMETMEFFGQFGEDEEDIYNELAENGFGHKIGGYASFTQHDPREYAYKEHTIML LQIDSDDDIDSMWGDVGIANFFITPEDLRKKDFSNVLYNWDCS*" /label="ywqG CDS" gene complement(3379625..3380410) /gene="ywqG" /locus_tag="BSU_36220" /old_locus_tag="BSU36220" /label="ywqG gene" S_feature complement(3380411..3380526) /Source="Nicolas_S_feature" /locus_tag="new_3729297_3729412_c" /HighExp="HiOs, T-1.40H, T-2.40H, T-3.40H, M9-tran, MG 150, SMM, GM 150, T0.0H, T-1.10H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1393" promotor_-10 complement(3380519..3380538) /Source="Nicolas_upshift_promotors" /id="U2835" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig="0.998001998001998" /xcortree=3015 /SigmaFactorBS="tggttgcgcaccagtctttttttcatcTATTGCGGggtgctg aatacaTTTGCTACTATTTAACTATTgtttggaaaattatgcagaagtagggcttctt t" /listShort="S1393, ywqG, S1392" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3380526) /Source="Nicolas_upshifts" /id="U2835" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig="0.998001998001998" /xcortree=3015 /SigmaFactorBS="tggttgcgcaccagtctttttttcatcTATTGCGGggtgctg aatacaTTTGCTACTATTTAACTATTgtttggaaaattatgcagaagtagggcttctt t" /listShort="S1393, ywqG, S1392" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3380552..3380559) /Source="Nicolas_upshift_promotors" /id="U2835" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.528471528471528" /psig="0.998001998001998" /xcortree=3015 /SigmaFactorBS="tggttgcgcaccagtctttttttcatcTATTGCGGggtgctg aatacaTTTGCTACTATTTAACTATTgtttggaaaattatgcagaagtagggcttctt t" /listShort="S1393, ywqG, S1392" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3380602..3381924) /gene="uglF" /locus_tag="BSU_36230" /old_locus_tag="BSU36230" /EC_number="1.1.1.22" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12970183, 15741737, 15866923, 16415592" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12970183, 15741737, 15866923, 16415592; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-glucose dehydrogenase" /protein_id="NP_391504.1" /db_xref="EnsemblGenomes-Gn:BSU36230" /db_xref="EnsemblGenomes-Tr:CAB15640" /db_xref="GOA:P96718" /db_xref="InterPro:IPR001732" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR014026" /db_xref="InterPro:IPR014027" /db_xref="InterPro:IPR017476" /db_xref="InterPro:IPR021157" /db_xref="InterPro:IPR028357" /db_xref="InterPro:IPR036220" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12510" /db_xref="UniProtKB/Swiss-Prot:P96718" /translation="MNITVIGTGYVGLVTGVSLSEIGHHVTCIDIDAHKIDEMRKGIS PIFEPGLEELMRKNTADGRLNFETSYEKGLAQADIIFIAVGTPQKSDGHANLEQITDA AKRIAKHVKRDTVVVTKSTVPVGTNDLINGLITEHLAEPVSISVASNPEFLREGSAIY DTFHGDRIVIGTADEKTANTLEELFRPFQIPIYQTDIRSAEMIKYASNAFLATKISFI NEISNICEKVGADIEAVAYGMGQDKRIGSQFLKAGIGYGGSCFPKDTNALVQIAGNVE HDFELLKSVIKVNNNQQAMLVDKALNRLGGVTGKTIALLGLSFKPNTDDMREAPSIVI ADRLAALDARIRAYDPIAVSHAKHVLPQAVEYKETIEEAVKGSDAVMILTDWADIKQF PLAAYQDLMETPLIFDGRNCYTLDEALAAGVEYYSVGRKAVVPSGAIQ*" /label="uglF CDS" gene complement(3380602..3381924) /gene="uglF" /locus_tag="BSU_36230" /old_locus_tag="BSU36230" /label="uglF gene" downshifts complement(3380614) /Source="Nicolas_upshifts" /id="D1872" /incds=0 /nref=137 /ntot=221 /MaxReadThrough="3.29767" /MaxDrop="6.20721" /score="16.9931891" /energy="-8.4" /TU="NA" /idTUdmin="U2836" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts complement(3381958) /Source="Nicolas_upshifts" /id="U2836" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1018 /SigmaFactorBS="ggctatgcgggagatcattCGCATTcatgataggatgttcTC ATACGATATTACGGAAGctgcaaagcagcaatttaactgttggagggaaacaatgaat a" /listShort="ywqF" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3381960..3382085) /Source="Nicolas_S_feature" /locus_tag="new_3730846_3730971_c" /HighExp="dia15, H2O2, Diami, dia5, LBGstat, Paraq, LBGexp, G180, G150, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.13453899999999999" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1394" promotor_-10 complement(3381960..3381978) /Source="Nicolas_upshift_promotors" /id="U2836" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1018 /SigmaFactorBS="ggctatgcgggagatcattCGCATTcatgataggatgttcTC ATACGATATTACGGAAGctgcaaagcagcaatttaactgttggagggaaacaatgaat a" /listShort="ywqF" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3381994..3381999) /Source="Nicolas_upshift_promotors" /id="U2836" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1018 /SigmaFactorBS="ggctatgcgggagatcattCGCATTcatgataggatgttcTC ATACGATATTACGGAAGctgcaaagcagcaatttaactgttggagggaaacaatgaat a" /listShort="ywqF" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(3382065..3382084) /Source="Nicolas_upshift_promotors" /id="U2837" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.817182817182817" /psig="0.993006993006993" /xcortree=1828 /SigmaFactorBS="agaagaaaattgtttggttttttttaacagccgattctcatt tcaccactttctttttgagAGCGATATAATAGTGTATTGtatggttgaatcacatttc a" /listShort="S1394, ywqF" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3382085) /Source="Nicolas_upshifts" /id="U2837" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.817182817182817" /psig="0.993006993006993" /xcortree=1828 /SigmaFactorBS="agaagaaaattgtttggttttttttaacagccgattctcatt tcaccactttctttttgagAGCGATATAATAGTGTATTGtatggttgaatcacatttc a" /listShort="S1394, ywqF" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3382119..3382883) /gene="ptpZ" /locus_tag="BSU_36240" /old_locus_tag="BSU36240" /EC_number="3.1.3.48" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15866923, 16415592, 16549871, 21605684, 27148221" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15866923, 16415592, 16549871, 21605684, 27148221; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein tyrosine-phosphatase" /protein_id="NP_391505.1" /db_xref="EnsemblGenomes-Gn:BSU36240" /db_xref="EnsemblGenomes-Tr:CAB15641" /db_xref="GOA:P96717" /db_xref="InterPro:IPR016195" /db_xref="InterPro:IPR016667" /db_xref="PDB:3QY6" /db_xref="PDB:3QY7" /db_xref="SubtiList:BG12509" /db_xref="UniProtKB/Swiss-Prot:P96717" /translation="MIDIHCHILPAMDDGAGDSADSIEMARAAVRQGIRTIIATPHHN NGVYKNEPAAVREAADQLNKRLIKEDIPLHVLPGQEIRIYGEVEQDLAKRQLLSLNDT KYILIEFPFDHVPRYAEQLFYDLQLKGYIPVIAHPERNREIRENPSLLYHLVEKGAAS QITSGSLAGIFGKQLKAFSLRLVEANLIHFVASDAHNVKTRNFHTQEALYVLEKEFGS ELPYMLTENAELLLRNQTIFRQPPQPVKRRKLFGFF*" /label="ptpZ CDS" gene complement(3382119..3382883) /gene="ptpZ" /locus_tag="BSU_36240" /old_locus_tag="BSU36240" /label="ptpZ gene" downshifts complement(3382902) /Source="Nicolas_upshifts" /id="D1873" /incds=0 /nref=4 /ntot=152 /MaxReadThrough="3.17433" /MaxDrop="3.31415" /score="15.8630799" /energy="-9.3" /TU="U2838" /idTUdmin="U2838" /TUdmin="-330" /isTUend="FALSE" /label="downshifts" CDS complement(3382936..3383649) /gene="ptkA" /locus_tag="BSU_36250" /old_locus_tag="BSU36250" /EC_number="2.7.10.2" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12970183, 15741737, 16415592, 16549871, 17367396, 20497499, 20815827, 23939619, 24493247, 26283769, 27148221" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12970183, 15741737, 16415592, 16549871, 17367396, 20497499, 20815827, 23939619, 24493247, 26283769, 27148221; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="maintenance protein tyrosine kinase involved in biofilm formation" /protein_id="NP_391506.1" /db_xref="EnsemblGenomes-Gn:BSU36250" /db_xref="EnsemblGenomes-Tr:CAB15642" /db_xref="GOA:P96716" /db_xref="InterPro:IPR005702" /db_xref="InterPro:IPR025669" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12508" /db_xref="UniProtKB/Swiss-Prot:P96716" /translation="MALRKNRGSRMQRNVIAMTEPKSLNSEQYRTIRTNIEFASVDRQ MKSVMITSACPGEGKSTTAANLAVVFAQQGKKVLLIDADLRKPTVHTAFFLENTVGLT SVLLKKSSMEQAVQASNEKHLDVLTSGPIPPNPAELLSSKWMKELAYEACAAYDMVIF DTPPILAVADAQILGNVADGSVLVISSGKTEKEQAAKAKEALATCKSKLLGAIMNGKK LSKHSEYGYYGTKDNFMQK*" /label="ptkA CDS" gene complement(3382936..3383649) /gene="ptkA" /locus_tag="BSU_36250" /old_locus_tag="BSU36250" /label="ptkA gene" downshifts complement(3382953) /Source="Nicolas_upshifts" /id="D1874" /incds=0 /nref=10 /ntot=157 /MaxReadThrough="4.4352" /MaxDrop="4.08842" /score="15.8630799" /energy="-9.3" /TU="U2838" /idTUdmin="U2838" /TUdmin="-381" /isTUend="FALSE" /label="downshifts" CDS complement(3383639..3384385) /gene="tkmA" /locus_tag="BSU_36260" /old_locus_tag="BSU36260" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12970183, 23939619, 24493247, 26283769" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12970183, 23939619, 24493247, 26283769; Product type r: regulator" /codon_start=1 /transl_table=11 /product="modulator of PtkA protein tyrosine kinase activity; modulation of biofilm formation" /protein_id="NP_391507.1" /db_xref="EnsemblGenomes-Gn:BSU36260" /db_xref="EnsemblGenomes-Tr:CAB15643" /db_xref="GOA:P96715" /db_xref="InterPro:IPR003856" /db_xref="InterPro:IPR032807" /db_xref="SubtiList:BG12507" /db_xref="UniProtKB/Swiss-Prot:P96715" /translation="MGESTSLKEILSTLTKRILLIMIVTAAATAAGGLISFFALTPIY ENSTQILVNQSKNERKEVQFNDVQTNLQLINTYNVIIKSPAILDEVIKEMGLSMTSQE LNDKITVSSEQDSQVVNISVRDENAETAAHIANTIASVFQDKITSIMNVDNVSILSKA EVSEHPSPVSPKPLLNIAIAFAAGLAGSIGLAFLLEHLDNTIKSEEQLESLLDIPVLG TVSTIANEQKTAKTLQGFQSEKTGSGHFGA*" /label="tkmA CDS" gene complement(3383639..3384385) /gene="tkmA" /locus_tag="BSU_36260" /old_locus_tag="BSU36260" /label="tkmA gene" promotor_-10 complement(3384417..3384436) /Source="Nicolas_upshift_promotors" /id="U2838" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.513486513486514" /psig=1 /xcortree=2281 /SigmaFactorBS="gtaaaaaaatgtcgaattatgtcacgtgaaaagCTGGagaaa tgcggtttcaaCGTTGTATAATCGTAGATGGaaaaggatgttataagagatttggagg t" /listShort="ywqC, ptkA, ywqE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3384429) /Source="Nicolas_upshifts" /id="U2838" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.513486513486514" /psig=1 /xcortree=2281 /SigmaFactorBS="gtaaaaaaatgtcgaattatgtcacgtgaaaagCTGGagaaa tgcggtttcaaCGTTGTATAATCGTAGATGGaaaaggatgttataagagatttggagg t" /listShort="ywqC, ptkA, ywqE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3384453..3384456) /Source="Nicolas_upshift_promotors" /id="U2838" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.513486513486514" /psig=1 /xcortree=2281 /SigmaFactorBS="gtaaaaaaatgtcgaattatgtcacgtgaaaagCTGGagaaa tgcggtttcaaCGTTGTATAATCGTAGATGGaaaaggatgttataagagatttggagg t" /listShort="ywqC, ptkA, ywqE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3384619..3384762) /gene="ywzD" /locus_tag="BSU_36269" /old_locus_tag="BSU36269" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 20709900" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097792.1" /db_xref="EnsemblGenomes-Gn:BSU36269" /db_xref="EnsemblGenomes-Tr:CAX52703" /db_xref="UniProtKB/Swiss-Prot:C0H3S3" /translation="MSEKKLNQEEFLKILMHAHEIGEQSSEMTTKEMLENLISHIKNG YAT*" /label="ywzD CDS" gene complement(3384619..3384762) /gene="ywzD" /locus_tag="BSU_36269" /old_locus_tag="BSU36269" /label="ywzD gene" downshifts complement(3384640) /Source="Nicolas_upshifts" /id="D1875" /incds=0 /nref=221 /ntot=264 /MaxReadThrough="2.76798" /MaxDrop="8.13076" /score="15.8630799" /energy="-9.3" /TU="U2839" /idTUdmin="U2841" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(3384763..3384848) /Source="Nicolas_S_feature" /locus_tag="new_3733649_3733734_c" /HighExp="S6, S8, S7, MG-0.2, S5, M9-stat, MG-0.1, MG 25, T0.30H, BT" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigD, SigK" /TUshortPSig="0.275, 1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1395" misc_feature complement(3384838..3384849) /Source="Nicolas_upshift_promotors" /id="U2839" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.290709290709291" /psig="0.274725274725275" /xcortree=1473 /SigmaFactorBS="caacacatcggccttaaaaagtttttcctaaaaaaggacata aaaaataggatgtgtcgAATGATGTATTAgagattgcaaattgataaccagcatcata t" /listShort="S1395, ywzD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3384848) /Source="Nicolas_upshifts" /id="U2839" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.290709290709291" /psig="0.274725274725275" /xcortree=1473 /SigmaFactorBS="caacacatcggccttaaaaagtttttcctaaaaaaggacata aaaaataggatgtgtcgAATGATGTATTAgagattgcaaattgataaccagcatcata t" /listShort="S1395, ywzD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3384850..3385080) /Source="Nicolas_S_feature" /locus_tag="new_3733736_3733966_c" /HighExp="S6, S8, S7, S5, BT, Cold, LBGstat, LPhT, Pyr, C30" /AntisenseName="ywqB" /AntisenseCor="3.4267833233812203E-2" /AntisenseRegPval="-0.2" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigK" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1396" promotor_-35 3384887..3384891 /Source="Nicolas_upshift_promotors" /id="U2840" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2581 /SigmaFactorBS="atcctattttttatgtccttttttaggaaaaACTTTttaagg ccgatgtgtTGCGATATAATAGAGAAATTggatctttttattacgtgactcggttagg a" /listShort="ywqB, ywqA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3384907..3384926 /Source="Nicolas_upshift_promotors" /id="U2840" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2581 /SigmaFactorBS="atcctattttttatgtccttttttaggaaaaACTTTttaagg ccgatgtgtTGCGATATAATAGAGAAATTggatctttttattacgtgactcggttagg a" /listShort="ywqB, ywqA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3384916 /Source="Nicolas_upshifts" /id="U2840" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.798201798201798" /psig=1 /xcortree=2581 /SigmaFactorBS="atcctattttttatgtccttttttaggaaaaACTTTttaagg ccgatgtgtTGCGATATAATAGAGAAATTggatctttttattacgtgactcggttagg a" /listShort="ywqB, ywqA" /GFF_Attribute="listLong" /label="upshifts" CDS 3384966..3386576 /gene="ywqB" /locus_tag="BSU_36270" /old_locus_tag="BSU36270" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22720735; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative replication initiation protein" /protein_id="NP_391508.2" /db_xref="EnsemblGenomes-Gn:BSU36270" /db_xref="EnsemblGenomes-Tr:CAB15644" /db_xref="GOA:P96714" /db_xref="InterPro:IPR007527" /db_xref="SubtiList:BG12506" /db_xref="UniProtKB/Swiss-Prot:P96714" /translation="MLQNMISKDDVLASAEQLKELLPYNEENVQLIKKALILYRQDSV YRLQAVSPTEVTAYVQDVVPVRVTLNLFVIVKSGCSCPSGRICRHMLAVFLYVYAMFE RVGTFTEYWLEREKLEESKELVRRQFQEKVLPNEESLSSWLAFFDSEFSLWQARTPEG SQNMQGLYYGYLSALKKHAPNKPELKSLYQIHSAIAVWLRMFTLIEAGKLNPEQDFYS LNPYVEQLMDTIYSSIDKLKTYALSFALDPFLDKTPDVIRHLLLKEEIFQYERIRVFG EIWSALLSRPKWVAREQEILKKEAGRRFSPELQFGRLHLEFLQKNDDVIFEEADQFPP EALPYTFQWLSEMTAKKDWKRLKTWYQQIEPIAMGYTKLDKPFKEIRDVIGELFLLLN AYVQQTNDQALFERFAAGCLPYTFTEYSHHLYEKKRYAEWIEIHSLVGFSINEMDKMM LKEIAASDPEALIPAYHREVAFFIDQKNRSSYKEAARYLKKLRTLYKKAKKQKVWERY IQLLSSHYKRLRALQEELQKGKLIDGES*" /label="ywqB CDS" gene 3384966..3386576 /gene="ywqB" /locus_tag="BSU_36270" /old_locus_tag="BSU36270" /label="ywqB gene" promotor_-10 complement(3385068..3385086) /Source="Nicolas_upshift_promotors" /id="U2841" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2784 /SigmaFactorBS="cgtaagccgtaacttccgtcggactcactgcttGTAAACGAt agactgaatcctGCCGATATAAAATAAGGGCttttttgatcagctgaacattttcctc a" /listShort="S1396, S1395, ywzD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3385080) /Source="Nicolas_upshifts" /id="U2841" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2784 /SigmaFactorBS="cgtaagccgtaacttccgtcggactcactgcttGTAAACGAt agactgaatcctGCCGATATAAAATAAGGGCttttttgatcagctgaacattttcctc a" /listShort="S1396, S1395, ywzD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3385082..3385256) /Source="Nicolas_S_feature" /locus_tag="new_3733968_3734142_c" /HighExp="S6, S8, S7, S5, BT, B36, G/S, Pyr, B60, C30" /AntisenseName="ywqB" /AntisenseCor="-0.10880748846525" /AntisenseRegPval="-1.1000000000000001" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1397" promotor_-35 complement(3385100..3385107) /Source="Nicolas_upshift_promotors" /id="U2841" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2784 /SigmaFactorBS="cgtaagccgtaacttccgtcggactcactgcttGTAAACGAt agactgaatcctGCCGATATAAAATAAGGGCttttttgatcagctgaacattttcctc a" /listShort="S1396, S1395, ywzD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3385243..3385262) /Source="Nicolas_upshift_promotors" /id="U2842" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1319 /SigmaFactorBS="aagcttttccctctccagccaatactctgtaaAAGTACCCAc tcgctcgaacatTGCATATACATATAAAAACAcagccagcatatggcggcagattctt c" /listShort="S1397, S1396, S1395, ywzD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3385256) /Source="Nicolas_upshifts" /id="U2842" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1319 /SigmaFactorBS="aagcttttccctctccagccaatactctgtaaAAGTACCCAc tcgctcgaacatTGCATATACATATAAAAACAcagccagcatatggcggcagattctt c" /listShort="S1397, S1396, S1395, ywzD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3385276..3385284) /Source="Nicolas_upshift_promotors" /id="U2842" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1319 /SigmaFactorBS="aagcttttccctctccagccaatactctgtaaAAGTACCCAc tcgctcgaacatTGCATATACATATAAAAACAcagccagcatatggcggcagattctt c" /listShort="S1397, S1396, S1395, ywzD" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3386563..3389331 /gene="hepA" /locus_tag="BSU_36280" /old_locus_tag="BSU36280" /function="16.9: Replicate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9507009, 9614128, 11751638, 17913745, 19282450; Product type f: factor" /codon_start=1 /transl_table=11 /product="ATPase involved in RNA remodelling DNA recombination and repair" /protein_id="NP_391509.1" /db_xref="EnsemblGenomes-Gn:BSU36280" /db_xref="EnsemblGenomes-Tr:CAB15645" /db_xref="GOA:P94593" /db_xref="InterPro:IPR000330" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR022138" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12505" /db_xref="UniProtKB/Swiss-Prot:P94593" /translation="MASLKEILIHVEQMEDGSFTLSAFDENEQPLPYSHMKKHLFQWH ESSFYGTFLEDVSFIGTTAVLLSPWMTVELLGKNSFNSFSSVQLTEETEPLIEAASTI YEFIADGDFMPDYDAWTNGVFRWKDRDNILEGFTAEWFSAAVQDYIQYDDDLREKWEH IKEKSPAVTTFRGHFLDEEDFLEGIGWIDDQSPFTVGLRLNEPDFDGDEWKIEMFLRD KKSGAVEFFDGLKSLKKSWQAYSDKIAREQDRFHRTVPWLSFDSGTTLISEEEAWIFL SEASETLVDMGVEILLPSWWQIVRDSNMMLKAKVSSSPRGESFVGMNALLDFNWRFAT NGIELTEAEFNELVASNRRLVNIRGQWVKIDPQFIKQMKRLMEKAESEGLHMSDILAR ELMDQQDGGLEDSDLIDTSAFAGIQFDLSKQLRSLIRKLTAAENLPEHKVSPSFKGTL RPYQKYGMNWLLFLRESGFGACLADDMGLGKTIQMIAYFLHVKESGRQKTPHLIIAPT SVLGNWQRELQTFAPDLSVALHYGPRRPKGDDFAAHYENADVVLTSYGLSHADTEELS SVTWNTICLDEAQNIKNAHTKQSRAIRKLKGLHHIALSGTPMENRLTELWSIFDFMNK GYLGSLTGFHKRYVLPIEKDRDEKRIGQLQQLIRPFLLRRTKRDEEVALNLPEKLEEK EFIPLSAEQASLYEQLVKDTFDHMTSLTGMQRKALILSMLGRLKQICDHPALYLKEEQ TELLAGRSVKLEKLLELMTAIRAQNESCLIFTQYIQMGNMMKRLLEKTFGEPVQFLNG SLSKQERDTLVEKFQRKEYPTLILSLKAGGTGLNLTAANHVIHYDRWWNPAVENQATD RAYRIGQERFVHVHKMITTGTIEEKIDVMLESKQTLNDQIIQSENWITELSTQELEEL FTLSATAQ*" /label="hepA CDS" gene 3386563..3389331 /gene="hepA" /locus_tag="BSU_36280" /old_locus_tag="BSU36280" /label="hepA gene" downshifts complement(3389380) /Source="Nicolas_upshifts" /id="D1876" /incds=0 /nref=9 /ntot=202 /MaxReadThrough="1.80101" /MaxDrop="4.14573" /score="30.708119" /energy="-14.4" /TU="U2843" /idTUdmin="U2844" /TUdmin=12 /isTUend="TRUE" /label="downshifts" CDS complement(3389457..3390314) /gene="ywpJ" /locus_tag="BSU_36290" /old_locus_tag="BSU36290" /EC_number="3.1.3.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 25848029; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphatase of unidentified specificity (possibly promiscuous)" /protein_id="NP_391510.1" /db_xref="EnsemblGenomes-Gn:BSU36290" /db_xref="EnsemblGenomes-Tr:CAB15646" /db_xref="GOA:P94592" /db_xref="InterPro:IPR000150" /db_xref="InterPro:IPR006379" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="PDB:1NRW" /db_xref="SubtiList:BG12504" /db_xref="UniProtKB/Swiss-Prot:P94592" /translation="MKLIAIDLDGTLLNSKHQVSLENENALRQAQRDGIEVVVSTGRA HFDVMSIFEPLGIKTWVISANGAVIHDPEGRLYHHETIDKKRAYDILSWLESENYYYE VFTGSAIYTPQNGRELLDVELDRFRSANPEADLSVLKQAAEVQYSQSGFAYINSFQEL FEADEPIDFYNILGFSFFKEKLEAGWKRYEHAEDLTLVSSAEHNFELSSRKASKGQAL KRLAKQLNIPLEETAAVGDSLNDKSMLEAAGKGVAMGNAREDIKSIADAVTLTNDEHG VAHMMKHLL*" /label="ywpJ CDS" gene complement(3389457..3390314) /gene="ywpJ" /locus_tag="BSU_36290" /old_locus_tag="BSU36290" /label="ywpJ gene" CDS complement(3390320..3391096) /gene="glcR" /locus_tag="BSU_36300" /old_locus_tag="BSU36300" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11491085" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11491085; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (glucose repression ofcatabolic operons)" /protein_id="NP_391511.1" /db_xref="EnsemblGenomes-Gn:BSU36300" /db_xref="EnsemblGenomes-Tr:CAB15647" /db_xref="GOA:P94591" /db_xref="InterPro:IPR001034" /db_xref="InterPro:IPR014036" /db_xref="InterPro:IPR018356" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12503" /db_xref="UniProtKB/Swiss-Prot:P94591" /translation="MYQEERLVAILDFLKQHNRITTEQICTLLQVSRDTARRDLVKLE EQNAIIRTRGGAILPTVHQKIQSYSGRLKTVSEEKNKIGRLAASLIHDGDRVILDAST TVQACAKHLNAVDCTVITNSINLADVLSDKEGIEIYLLGGKLEKEHRFLYGSSVIEKL SSYHVDKALIGVVGISEHGITIAHEEDGMVKRKMIQQAKQVIALADHSKLGSTSFYQY AELNEIDLLITDRLPNQAFCDLLDRNGVELLVTEQDEGKD*" /label="glcR CDS" gene complement(3390320..3391096) /gene="glcR" /locus_tag="BSU_36300" /old_locus_tag="BSU36300" /label="glcR gene" promotor_-10 complement(3391122..3391141) /Source="Nicolas_upshift_promotors" /id="U2843" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=3012 /SigmaFactorBS="ttggttctctcgacgcatttttacttaaaatcacttattaaT GTTGAATaaaatcaaataaaaACTTATAATTACTTATAAATgattgctgagaaaagga a" /listShort="glcR, ywpJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3391144) /Source="Nicolas_upshifts" /id="U2843" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=3012 /SigmaFactorBS="ttggttctctcgacgcatttttacttaaaatcacttattaaT GTTGAATaaaatcaaataaaaACTTATAATTACTTATAAATgattgctgagaaaagga a" /listShort="glcR, ywpJ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3391146..3391218) /Source="Nicolas_S_feature" /locus_tag="new_3740032_3740104_c" /HighExp="C30, GM 150, T-4.40H, G/S, C90, S2, T-5.40H, T-3.40H, T-2.40H, S0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1398" promotor_-35 complement(3391156..3391163) /Source="Nicolas_upshift_promotors" /id="U2843" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.963036963036963" /psig=1 /xcortree=3012 /SigmaFactorBS="ttggttctctcgacgcatttttacttaaaatcacttattaaT GTTGAATaaaatcaaataaaaACTTATAATTACTTATAAATgattgctgagaaaagga a" /listShort="glcR, ywpJ" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3391220..3391319) /Source="Nicolas_S_feature" /locus_tag="new_3740106_3740205_c" /HighExp="HiOs, S2, T-3.40H, T0.30H, C90, G/S, T1.0H, T0.0H, Pyr, T-1.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1399" downshifts complement(3391263) /Source="Nicolas_upshifts" /id="D1877" /incds=0 /nref=221 /ntot=258 /MaxReadThrough="3.81096" /MaxDrop="7.17295" /score="-7.00620083" /energy="-7.5" /TU="U2844" /idTUdmin="U2846" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" CDS complement(3391320..3391661) /gene="ssbB" /locus_tag="BSU_36310" /old_locus_tag="BSU36310" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:14762004, 16009133, 16549871, 17630974, 25138221" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14762004, 16009133, 16549871, 17630974, 25138221; Product type f: factor" /codon_start=1 /transl_table=11 /product="single-strand DNA-binding protein" /protein_id="NP_391512.2" /db_xref="EnsemblGenomes-Gn:BSU36310" /db_xref="EnsemblGenomes-Tr:CAB15648" /db_xref="GOA:C0SPB6" /db_xref="InterPro:IPR000424" /db_xref="InterPro:IPR011344" /db_xref="InterPro:IPR012340" /db_xref="PDB:3VDY" /db_xref="SubtiList:BG12502" /db_xref="UniProtKB/Swiss-Prot:C0SPB6" /translation="MFNQVMLVGRLTKDPDLRYTSAGAAVAHVTLAVNRSFKNASGEI EADYVNCTLWRKTAENTALYCQKGSLVGVSGRIQTRSYENEEGVNVYVTEVLADTVRF MDPKPREKAAD*" /label="ssbB CDS" gene complement(3391320..3391661) /gene="ssbB" /locus_tag="BSU_36310" /old_locus_tag="BSU36310" /label="ssbB gene" promotor_-10 complement(3391683..3391702) /Source="Nicolas_upshift_promotors" /id="U2844" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.89010989010989" /psig=1 /xcortree=2964 /SigmaFactorBS="aacgaaagataaaaacagaggctgaaagccatttttaagCGT TTTTCttttcttgttgcaTCATTTACAATACATACAACcgcaaggagaggaggaatcg c" /listShort="ssbB, S1399, S1398, glcR, ywpJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3391702) /Source="Nicolas_upshifts" /id="U2844" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.89010989010989" /psig=1 /xcortree=2964 /SigmaFactorBS="aacgaaagataaaaacagaggctgaaagccatttttaagCGT TTTTCttttcttgttgcaTCATTTACAATACATACAACcgcaaggagaggaggaatcg c" /listShort="ssbB, S1399, S1398, glcR, ywpJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3391716..3391723) /Source="Nicolas_upshift_promotors" /id="U2844" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.89010989010989" /psig=1 /xcortree=2964 /SigmaFactorBS="aacgaaagataaaaacagaggctgaaagccatttttaagCGT TTTTCttttcttgttgcaTCATTTACAATACATACAACcgcaaggagaggaggaatcg c" /listShort="ssbB, S1399, S1398, glcR, ywpJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3391738..3392121) /gene="ywpG" /locus_tag="BSU_36320" /old_locus_tag="BSU36320" /experiment="publication(s) with functional evidences, PMID:23060960" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 23060960; Product type f: factor" /codon_start=1 /transl_table=11 /product="interaction partner of DynA" /protein_id="NP_391513.1" /db_xref="EnsemblGenomes-Gn:BSU36320" /db_xref="EnsemblGenomes-Tr:CAB15649" /db_xref="SubtiList:BG12501" /db_xref="UniProtKB/Swiss-Prot:P94589" /translation="MNQFRLKEIYIDGVPSESHLIQKEVTYMLSRKEVFEVHLNKKGR ISFLYETQDGMEQYKIKLSMPEKKLSFQWFAWDGSSYVRMNTQNWLTKQIFFRFLKST YFFKGKKQKMFLAEGKMKTKDKNRG*" /label="ywpG CDS" gene complement(3391738..3392121) /gene="ywpG" /locus_tag="BSU_36320" /old_locus_tag="BSU36320" /label="ywpG gene" promotor_-10 complement(3392143..3392162) /Source="Nicolas_upshift_promotors" /id="U2846" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2300 /SigmaFactorBS="cctgcaatgttggggctaaagaattttgtatgagcgaaaCAT TTAATaatttctattttttCATTATACTGTAACTGACTAtggattacggagagatgtg g" /listShort="ywpG, ssbB, S1399" /listLong="S1398, glcR, ywpJ" /label="promotor_-10" misc_feature 3392150..3392169 /Source="Nicolas_upshift_promotors" /id="U2845" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.502497502497502" /psig="0.973026973026973" /xcortree=3123 /SigmaFactorBS="aaatttcttttaaacgaaattgattcataccacatctctccg taatccatagtcagTTACAGTATAATGAAAAAATagaaattattaaatgtttcgctca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3392154 /Source="Nicolas_upshifts" /id="U2845" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.502497502497502" /psig="0.973026973026973" /xcortree=3123 /SigmaFactorBS="aaatttcttttaaacgaaattgattcataccacatctctccg taatccatagtcagTTACAGTATAATGAAAAAATagaaattattaaatgtttcgctca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(3392163) /Source="Nicolas_upshifts" /id="U2846" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2300 /SigmaFactorBS="cctgcaatgttggggctaaagaattttgtatgagcgaaaCAT TTAATaatttctattttttCATTATACTGTAACTGACTAtggattacggagagatgtg g" /listShort="ywpG, ssbB, S1399" /listLong="S1398, glcR, ywpJ" /label="upshifts" promotor_-35 complement(3392177..3392184) /Source="Nicolas_upshift_promotors" /id="U2846" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.977022977022977" /psig=1 /xcortree=2300 /SigmaFactorBS="cctgcaatgttggggctaaagaattttgtatgagcgaaaCAT TTAATaatttctattttttCATTATACTGTAACTGACTAtggattacggagagatgtg g" /listShort="ywpG, ssbB, S1399" /listLong="S1398, glcR, ywpJ" /label="promotor_-35" misc_feature 3392244..3392263 /Source="Nicolas_upshift_promotors" /id="U2847" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.818181818181818" /psig=1 /xcortree=1915 /SigmaFactorBS="tcgctcatacaaaattctttagccccaacattgcaggatttt ttcctcgaaaacgttTATGTTATAATGGAAGGCAAgaaaactttggaagtaatcgggg t" /listShort="ywpF" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3392247 /Source="Nicolas_upshifts" /id="U2847" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.818181818181818" /psig=1 /xcortree=1915 /SigmaFactorBS="tcgctcatacaaaattctttagccccaacattgcaggatttt ttcctcgaaaacgttTATGTTATAATGGAAGGCAAgaaaactttggaagtaatcgggg t" /listShort="ywpF" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(3392296) /Source="Nicolas_upshifts" /id="D1878" /incds=0 /nref=2 /ntot=169 /MaxReadThrough="0.85282" /MaxDrop="4.02798" /score="27.231517" /energy="-14" /TU="NA" /idTUdmin="U2846" /TUdmin="-1034" /isTUend="FALSE" /label="downshifts" CDS 3392296..3392706 /gene="ywpF" /locus_tag="BSU_36330" /old_locus_tag="BSU36330" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 25663006" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391514.1" /db_xref="EnsemblGenomes-Gn:BSU36330" /db_xref="EnsemblGenomes-Tr:CAB15650" /db_xref="InterPro:IPR025573" /db_xref="SubtiList:BG12500" /db_xref="UniProtKB/Swiss-Prot:P94588" /translation="MKTFKLVDLNVERVDKEEQSIEQFPLIDGLIINKEDGENHWLIE ALVQKEHLSFFEQLQNSQSEAKVFVTITKKSNRPAQLTAAVKNIVKLEESIQVLLYGQ MVTRKQQGTETILESLVKEGYTGTKLIEAFKQKL*" /label="ywpF CDS" gene 3392296..3392706 /gene="ywpF" /locus_tag="BSU_36330" /old_locus_tag="BSU36330" /label="ywpF gene" S_feature 3392707..3392790 /Source="Nicolas_S_feature" /locus_tag="new_3741593_3741676" /HighExp="BC, LBGtran, T3.30H, Etha, T2.0H, Lbtran, M9-stat, T3.0H, dia5, LBGstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1400" downshifts 3392748 /Source="Nicolas_upshifts" /id="D1879" /incds=0 /nref=214 /ntot=260 /MaxReadThrough="1.83981" /MaxDrop="6.19197" /score="18.4023831" /energy="-14" /TU="NA" /idTUdmin="U2847" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3392846..3393154) /gene="ywpE" /locus_tag="BSU_36340" /old_locus_tag="BSU36340" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15187182, 21800427, 21906378; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sortase" /protein_id="NP_391515.1" /db_xref="EnsemblGenomes-Gn:BSU36340" /db_xref="EnsemblGenomes-Tr:CAB15651" /db_xref="GOA:P94587" /db_xref="InterPro:IPR005754" /db_xref="InterPro:IPR023365" /db_xref="SubtiList:BG12499" /db_xref="UniProtKB/Swiss-Prot:P94587" /translation="MRRDQKMGEGNYPLAGHHLKQKNLLFGPLENIKTGAQIVITDFK KDYIYSVTSKDIISEMDADVVEETNKKEITLITCDKAVKTEGRLVVKGELVDSFGHTN *" /label="ywpE CDS" gene complement(3392846..3393154) /gene="ywpE" /locus_tag="BSU_36340" /old_locus_tag="BSU36340" /label="ywpE gene" downshifts complement(3392847) /Source="Nicolas_upshifts" /id="D1880" /incds=0 /nref=1 /ntot=36 /MaxReadThrough="0.11027" /MaxDrop="2.8132" /score="27.231517" /energy="-14" /TU="NA" /idTUdmin="U2849" /TUdmin=1540 /isTUend="FALSE" /label="downshifts" CDS 3393498..3394334 /gene="ywpD" /locus_tag="BSU_36350" /old_locus_tag="BSU36350" /function="16.12: Sense" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16740923; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="putative two-component sensor histidine kinase" /protein_id="NP_391516.1" /db_xref="EnsemblGenomes-Gn:BSU36350" /db_xref="EnsemblGenomes-Tr:CAB15652" /db_xref="GOA:P94586" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR010559" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG12498" /db_xref="UniProtKB/Swiss-Prot:P94586" /translation="MKIRERFSMVDLPVLIITAAIIGHDKYKAFHAGANDILQKPYHY SEFMARIQNLIMMKHTANQATRMEMAFLQSQIKPHFLYNVLNTIISLTHLDIEKAREV TEEFTNYLRMSFDFQNTSAISSFRHELSIINSYLSIEKTRFSNRLEVLFDIDEDIDFI LPPLMIQPLVENAVLHGVSKKRGGGWIKLTAKKQSKNEYHIKVEDNGPGITPEKQIDL LSTDFDRSVGLKNINQRLKHFCGSELMISSTPDAGTSVSMLIHLAETTGSPKELKDTE RT*" /label="ywpD CDS" gene 3393498..3394334 /gene="ywpD" /locus_tag="BSU_36350" /old_locus_tag="BSU36350" /label="ywpD gene" promotor_-35 3393714..3393721 /Source="Nicolas_upshift_promotors" /id="U2848" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.81918081918082" /psig="0.993006993006993" /xcortree=642 /SigmaFactorBS="caaatcaagccacaagaatggaaatggcgtttctcCAGTCGC AaatcaagcctcattTTCTTTATAATGTATTAAACacgattatttctctcactcattt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3393736..3393755 /Source="Nicolas_upshift_promotors" /id="U2848" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.81918081918082" /psig="0.993006993006993" /xcortree=642 /SigmaFactorBS="caaatcaagccacaagaatggaaatggcgtttctcCAGTCGC AaatcaagcctcattTTCTTTATAATGTATTAAACacgattatttctctcactcattt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3393739 /Source="Nicolas_upshifts" /id="U2848" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.81918081918082" /psig="0.993006993006993" /xcortree=642 /SigmaFactorBS="caaatcaagccacaagaatggaaatggcgtttctcCAGTCGC AaatcaagcctcattTTCTTTATAATGTATTAAACacgattatttctctcactcattt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 3394333 /Source="Nicolas_upshifts" /id="D1881" /incds=0 /nref=13 /ntot=132 /MaxReadThrough="0.11837" /MaxDrop="3.37937" /score="9.16906941" /energy="-8.6" /TU="NA" /idTUdmin="U2848" /TUdmin=154 /isTUend="FALSE" /label="downshifts" CDS complement(3394381..3394773) /gene="mscL" /locus_tag="BSU_36360" /old_locus_tag="BSU36360" /function="16.1: Circulate" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12948773, 15063854, 15165739, 16897034, 22685134, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12948773, 15063854, 15165739, 16897034, 22685134, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="large conductance mechanosensitive channel protein" /protein_id="NP_391517.1" /db_xref="EnsemblGenomes-Gn:BSU36360" /db_xref="EnsemblGenomes-Tr:CAB15653" /db_xref="GOA:P94585" /db_xref="InterPro:IPR001185" /db_xref="InterPro:IPR019823" /db_xref="InterPro:IPR036019" /db_xref="SubtiList:BG12497" /db_xref="UniProtKB/Swiss-Prot:P94585" /translation="MWNEFKAFAMRGNIVDLAIGVVIGGAFGKIVTSLVNDIIMPLVG LLLGGLDFSGLSFTFGDAVVKYGSFIQTIVNFLIISFSIFIVIRTLNGLRRKKEAEEE AAEEAVDAQEELLKEIRDLLKQQAKSPE*" /label="mscL CDS" gene complement(3394381..3394773) /gene="mscL" /locus_tag="BSU_36360" /old_locus_tag="BSU36360" /label="mscL gene" downshifts complement(3394387) /Source="Nicolas_upshifts" /id="D1882" /incds=0 /nref=216 /ntot=255 /MaxReadThrough="2.23487" /MaxDrop="6.5103" /score="28.9904077" /energy="-11.4" /TU="NA" /idTUdmin="U2849" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3394846..3395271) /gene="fabZ" /locus_tag="BSU_36370" /old_locus_tag="BSU36370" /EC_number="4.2.1.59" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 8910376, 12682299, 15194690, 15371447, 18093984, 22580319, 23322253, 27874013; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="beta-hydroxyacyl-[acyl carrier protein] dehydratase" /protein_id="NP_391518.2" /db_xref="EnsemblGenomes-Gn:BSU36370" /db_xref="EnsemblGenomes-Tr:CAB15654" /db_xref="GOA:P94584" /db_xref="InterPro:IPR010084" /db_xref="InterPro:IPR013114" /db_xref="InterPro:IPR029069" /db_xref="SubtiList:BG12496" /db_xref="UniProtKB/Swiss-Prot:P94584" /translation="MLDTQQIKEIIPHRYPFLLVDRITEVEEGKRAKGYKNVTANEEF FNGHFPQYPVMPGVLIVEALAQVGAVAMLIKEENRGRLAFFAGIDNCRFKKQVKPGDQ LHLEVEIIRARGTIGRGKGVATVDGEVVCEVELTFALGE*" /label="fabZ CDS" gene complement(3394846..3395271) /gene="fabZ" /locus_tag="BSU_36370" /old_locus_tag="BSU36370" /label="fabZ gene" promotor_-10 complement(3395332..3395351) /Source="Nicolas_upshift_promotors" /id="U2849" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2557 /SigmaFactorBS="acggctctcattgacagttggttacattttagcgcGGTTGAA AaagagattaattcaTAATATACTTTTCAAATGTAcagattggatctttgatgattgc t" /listShort="fabZ, mscL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3395348) /Source="Nicolas_upshifts" /id="U2849" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2557 /SigmaFactorBS="acggctctcattgacagttggttacattttagcgcGGTTGAA AaagagattaattcaTAATATACTTTTCAAATGTAcagattggatctttgatgattgc t" /listShort="fabZ, mscL" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3395350..3395434) /Source="Nicolas_S_feature" /locus_tag="new_3744236_3744320_c" /HighExp="Diami, dia5, Cold, dia15, H2O2, C30, Etha, Oxctl, Paraq, M/G" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="SigD, SigA" /TUlongPSig="0.999, 0.837" /label="S1401" promotor_-35 complement(3395366..3395373) /Source="Nicolas_upshift_promotors" /id="U2849" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.865134865134865" /psig=1 /xcortree=2557 /SigmaFactorBS="acggctctcattgacagttggttacattttagcgcGGTTGAA AaagagattaattcaTAATATACTTTTCAAATGTAcagattggatctttgatgattgc t" /listShort="fabZ, mscL" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3395413 /Source="Nicolas_upshifts" /id="U2850" /multdbtbs="SigA,SigX" /comp="M4" /sig="SigA" /pcomp="0.956043956043956" /psig="0.988011988011988" /xcortree=3190 /SigmaFactorBS="gaattaatctctttttcaaccgcgctaaaatgtaaccaactg tcaatgagagccgtcaaaagtTATGATATGATAATTATAGAttttaccaatagcaaag a" /listShort="rapD, S1403" /GFF_Attribute="listLong" /label="upshifts" misc_feature 3395416..3395435 /Source="Nicolas_upshift_promotors" /id="U2850" /multdbtbs="SigA,SigX" /comp="M4" /sig="SigA" /pcomp="0.956043956043956" /psig="0.988011988011988" /xcortree=3190 /SigmaFactorBS="gaattaatctctttttcaaccgcgctaaaatgtaaccaactg tcaatgagagccgtcaaaagtTATGATATGATAATTATAGAttttaccaatagcaaag a" /listShort="rapD, S1403" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(3395426..3395445) /Source="Nicolas_upshift_promotors" /id="U2851" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.417582417582418" /psig="0.995004995004995" /xcortree=1970 /SigmaFactorBS="agcattcttttttcaataaacttcgaaatcATTTTCctacct ctttgctATTGGTAAAATCTATAATTAtcatatcataacttttgacggctctcattga c" /listShort="S1401" /listLong="fabZ, mscL" /label="promotor_-10" upshifts complement(3395434) /Source="Nicolas_upshifts" /id="U2851" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.417582417582418" /psig="0.995004995004995" /xcortree=1970 /SigmaFactorBS="agcattcttttttcaataaacttcgaaatcATTTTCctacct ctttgctATTGGTAAAATCTATAATTAtcatatcataacttttgacggctctcattga c" /listShort="S1401" /listLong="fabZ, mscL" /label="upshifts" S_feature complement(3395436..3396520) /Source="Nicolas_S_feature" /locus_tag="new_3744322_3745406_c" /HighExp="Cold, C30, Lbstat, Glucon, Glu, Paraq, Pyr, H2O2, Fru, C90" /AntisenseName="rapD" /AntisenseCor="5.8390464430913601E-3" /AntisenseRegPval=0 /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig="0.999" /TUlongSig="SigA" /TUlongPSig="0.837" /label="S1402" promotor_-35 complement(3395459..3395464) /Source="Nicolas_upshift_promotors" /id="U2851" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.417582417582418" /psig="0.995004995004995" /xcortree=1970 /SigmaFactorBS="agcattcttttttcaataaacttcgaaatcATTTTCctacct ctttgctATTGGTAAAATCTATAATTAtcatatcataacttttgacggctctcattga c" /listShort="S1401" /listLong="fabZ, mscL" /label="promotor_-35" CDS 3395463..3396527 /gene="rapD" /locus_tag="BSU_36380" /old_locus_tag="BSU36380" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17227471" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17227471; Product type r: regulator" /codon_start=1 /transl_table=11 /product="response regulator aspartate phosphatase" /protein_id="NP_391519.1" /db_xref="EnsemblGenomes-Gn:BSU36380" /db_xref="EnsemblGenomes-Tr:CAB15655" /db_xref="GOA:P94583" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="SubtiList:BG11967" /db_xref="UniProtKB/Swiss-Prot:P94583" /translation="MISKFIEKRMLNMLDEWYSAMSKRKMNHVCTLKEKIDQHLPKIK KNTKLWMRYQLFQARHQLLFENQNGLDSLFDGLYGLEDKMDDELKYYLYFFSGLYEMV KTAPKHAVHHFKKAEQYLAAIHNTFEAADLYYQTAGAYYLMKSPPLSVQYVKKALHIY LHQFGYIKKVITCKLLLAVNYIDQERYEKAEQLFKEIIKKTQQLHDENLLCHAYYNLG FLKATEKKDQEALLYFRKVLKNQEFEMNSPVSYLHCVYESVRALFKTGNITEAKAVLQ KGKELSEKVDIQTIYLKLKTLEALYTSAEDPYEQLLEYVLELEKIEAWVDLEVLLEDI TEYYKKKDDFEKAAFFIMRG*" /label="rapD CDS" gene 3395463..3396527 /gene="rapD" /locus_tag="BSU_36380" /old_locus_tag="BSU36380" /label="rapD gene" S_feature 3396528..3397412 /Source="Nicolas_S_feature" /locus_tag="new_3745414_3746298" /HighExp="M9-stat, T4.0H, T2.0H, T3.30H, T2.30H, T3.0H, T1.30H, T5.0H, T1.0H, T0.30H" /AntisenseName="flhP" /AntisenseCor="-0.32116112580252298" /AntisenseRegPval="-7.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S1403" CDS complement(3396550..3397359) /gene="flhP" /locus_tag="BSU_36390" /old_locus_tag="BSU36390" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:22730131" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22730131; Product type s: structure" /codon_start=1 /transl_table=11 /product="flagellar hook-basal body accessory protein" /protein_id="NP_391520.2" /db_xref="EnsemblGenomes-Gn:BSU36390" /db_xref="EnsemblGenomes-Tr:CAB15656" /db_xref="GOA:P39753" /db_xref="InterPro:IPR001444" /db_xref="InterPro:IPR010930" /db_xref="InterPro:IPR019776" /db_xref="InterPro:IPR020013" /db_xref="SubtiList:BG10918" /db_xref="UniProtKB/Swiss-Prot:P39753" /translation="MLRSMLTASTTLNQLQQQIDTISSNLSNSNTTGYKAKDTNFSEL VRQQFDQVDEKNEEVAKARKTPPGLRLGVGAMMSSRLVSDQGSIQKTDRDLDIAFTSP YQYLQVNVNGNRQYTRDGALYVTPSAANANQLQLVTGNGYPVLDENGNTVNIDSSMKN ITINKNGTLTASDGNAVQRFNLGVVQVNNPQELKSEGNNLFSIDNAAAFEELNGANRQ NIGMQQGSLEMSNVDISEQMTDLITSQRSYQLNSRTITMGDQMLGLINSVR*" /label="flhP CDS" gene complement(3396550..3397359) /gene="flhP" /locus_tag="BSU_36390" /old_locus_tag="BSU36390" /label="flhP gene" downshifts complement(3396565) /Source="Nicolas_upshifts" /id="D1883" /incds=0 /nref=174 /ntot=256 /MaxReadThrough="4.65461" /MaxDrop="5.56507" /score="8.59904552" /energy="-7.4" /TU="U2853" /idTUdmin="U2854" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(3397393..3398205) /gene="flhO" /locus_tag="BSU_36400" /old_locus_tag="BSU36400" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1905667, 16621824, 22730131" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1905667, 16621824, 22730131; Product type s: structure" /codon_start=1 /transl_table=11 /product="flagellar basal-body accessory rod protein" /protein_id="NP_391521.1" /db_xref="EnsemblGenomes-Gn:BSU36400" /db_xref="EnsemblGenomes-Tr:CAB15657" /db_xref="GOA:P39752" /db_xref="InterPro:IPR001444" /db_xref="InterPro:IPR010930" /db_xref="InterPro:IPR019776" /db_xref="SubtiList:BG10917" /db_xref="UniProtKB/Swiss-Prot:P39752" /translation="MLKGLYTATSAMIAQQRRTEMLSNNIANANTSGYKADQGSMRAF PEMLLSRIESKSPAGTSRTEIGSVNTGVYMQELKPLFTQGSLKSTDQPTDIALIENQV PMSAETNEKAALFYPVQTADGIRYSKSSTFSLNENNQLTINGRPILSTDRQPITVDNE NFTVSENGTVTTNGRTAGQIDVRMAEDVRNLKRDGNDLYSTADGNDLPSAAGNNQVAY SLKQGVSELSNVDVTSAYTEMTEAYRSFEANQKVIQAYDKSMDKAANEIGKI*" /label="flhO CDS" gene complement(3397393..3398205) /gene="flhO" /locus_tag="BSU_36400" /old_locus_tag="BSU36400" /label="flhO gene" S_feature complement(3398206..3398285) /Source="Nicolas_S_feature" /locus_tag="new_3747092_3747171_c" /HighExp="C90, Lbtran, Cold, GM-0.2, GM 15, GM 10, C30, GM 90, GM-0.1, MG 150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigA" /TUshortPSig="0.999, 0.837" /TUlongSig="NA" /TUlongPSig="NA" /label="S1404" promotor_-35 3398236..3398243 /Source="Nicolas_upshift_promotors" /id="U2852" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2095 /SigmaFactorBS="atttcccacctctaaaaatggcattttttcCAGTTGTCatat aggaacgttCGTTCTATAATAAAAACTCAgtattttatcctattatcgtcatttaaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3398257..3398276 /Source="Nicolas_upshift_promotors" /id="U2852" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2095 /SigmaFactorBS="atttcccacctctaaaaatggcattttttcCAGTTGTCatat aggaacgttCGTTCTATAATAAAAACTCAgtattttatcctattatcgtcatttaaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3398266 /Source="Nicolas_upshifts" /id="U2852" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.93906093906094" /psig=1 /xcortree=2095 /SigmaFactorBS="atttcccacctctaaaaatggcattttttcCAGTTGTCatat aggaacgttCGTTCTATAATAAAAACTCAgtattttatcctattatcgtcatttaaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3398279..3398297) /Source="Nicolas_upshift_promotors" /id="U2853" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2805 /SigmaFactorBS="aagaatgaggtttttttatgaaaaagcCTTCACGAaaagatg ttaaatGACGATAATAGGATAAAATactgagtttttattatagaacgaacgttcctat a" /listShort="S1404, flhO, flhP, S1402" /listLong="S1401, fabZ, mscL" /label="promotor_-10" upshifts complement(3398285) /Source="Nicolas_upshifts" /id="U2853" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2805 /SigmaFactorBS="aagaatgaggtttttttatgaaaaagcCTTCACGAaaagatg ttaaatGACGATAATAGGATAAAATactgagtttttattatagaacgaacgttcctat a" /listShort="S1404, flhO, flhP, S1402" /listLong="S1401, fabZ, mscL" /label="upshifts" promotor_-35 complement(3398311..3398318) /Source="Nicolas_upshift_promotors" /id="U2853" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2805 /SigmaFactorBS="aagaatgaggtttttttatgaaaaagcCTTCACGAaaagatg ttaaatGACGATAATAGGATAAAATactgagtttttattatagaacgaacgttcctat a" /listShort="S1404, flhO, flhP, S1402" /listLong="S1401, fabZ, mscL" /label="promotor_-35" CDS complement(3398368..3399369) /gene="mbl" /locus_tag="BSU_36410" /old_locus_tag="BSU36410" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11290328, 12530960, 14588250, 15745453, 17064365, 19659933, 21091501, 23879732, 27215790" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11290328, 12530960, 14588250, 15745453, 17064365, 19659933, 21091501, 23879732, 27215790; Product type f: factor" /codon_start=1 /transl_table=11 /product="MreB-like morphogen" /protein_id="NP_391522.2" /db_xref="EnsemblGenomes-Gn:BSU36410" /db_xref="EnsemblGenomes-Tr:CAB15658" /db_xref="GOA:P39751" /db_xref="InterPro:IPR004753" /db_xref="SubtiList:BG10916" /db_xref="UniProtKB/Swiss-Prot:P39751" /translation="MFARDIGIDLGTANVLIHVKGKGIVLNEPSVVALDKNSGKVLAV GEEARRMVGRTPGNIVAIRPLKDGVIADFEVTEAMLKHFINKLNVKGLFSKPRMLICC PTNITSVEQKAIKEAAEKSGGKHVYLEEEPKVAAIGAGMEIFQPSGNMVVDIGGGTTD IAVISMGDIVTSSSIKMAGDKFDMEILNYIKREYKLLIGERTAEDIKIKVATVFPDAR HEEISIRGRDMVSGLPRTITVNSKEVEEALRESVAVIVQAAKQVLERTPPELSADIID RGVIITGGGALLNGLDQLLAEELKVPVLVAENPMDCVAIGTGVMLDNMDKLPKRKLS* " /label="mbl CDS" gene complement(3398368..3399369) /gene="mbl" /locus_tag="BSU_36410" /old_locus_tag="BSU36410" /label="mbl gene" downshifts complement(3398374) /Source="Nicolas_upshifts" /id="D1884" /incds=0 /nref=108 /ntot=240 /MaxReadThrough="5.6154" /MaxDrop="4.18076" /score="20.122637" /energy="-11.2" /TU="U2854" /idTUdmin="U2855" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" misc_feature complement(3399424..3399443) /Source="Nicolas_upshift_promotors" /id="U2854" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.561438561438561" /psig="0.837162837162837" /xcortree=799 /SigmaFactorBS="gttcataaaacatccgcaaaaatttgtaaagaacttattgtg cttccaactttttttctatatttTATGATAATATATATAATTAgggcacaatgtggat a" /listShort="mbl, S1404, flhO, flhP" /listLong="S1402, S1401, fabZ, mscL" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3399448) /Source="Nicolas_upshifts" /id="U2854" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.561438561438561" /psig="0.837162837162837" /xcortree=799 /SigmaFactorBS="gttcataaaacatccgcaaaaatttgtaaagaacttattgtg cttccaactttttttctatatttTATGATAATATATATAATTAgggcacaatgtggat a" /listShort="mbl, S1404, flhO, flhP" /listLong="S1402, S1401, fabZ, mscL" /label="upshifts" S_feature complement(3399450..3399534) /Source="Nicolas_S_feature" /locus_tag="new_3748336_3748420_c" /HighExp="S5, S6, S4, S7, S8, S3, B36, T5.0H, B60, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1405" CDS complement(3399535..3399816) /gene="spoIIID" /locus_tag="BSU_36420" /old_locus_tag="BSU36420" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9023218, 9324264, 15598884, 22720735, 24584501" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9023218, 9324264, 15598884, 22720735, 24584501; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (stage III sporulation)" /protein_id="NP_391523.1" /db_xref="EnsemblGenomes-Gn:BSU36420" /db_xref="EnsemblGenomes-Tr:CAB15659" /db_xref="GOA:P15281" /db_xref="InterPro:IPR014208" /db_xref="InterPro:IPR018356" /db_xref="InterPro:IPR036388" /db_xref="PDB:2L0K" /db_xref="SubtiList:BG10408" /db_xref="UniProtKB/Swiss-Prot:P15281" /translation="MHDYIKERTIKIGKYIVETKKTVRVIAKEFGVSKSTVHKDLTER LPEINPDLANEVKEILDYHKSIRHLRGGEATKLKYKKDEILEGEPVQQS*" /label="spoIIID CDS" gene complement(3399535..3399816) /gene="spoIIID" /locus_tag="BSU_36420" /old_locus_tag="BSU36420" /label="spoIIID gene" CDS complement(3399831..3399941) /gene="usd" /locus_tag="BSU_36430" /old_locus_tag="BSU36430" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9023218; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="putative factor required for translation of spoIIID" /protein_id="NP_391524.1" /db_xref="EnsemblGenomes-Gn:BSU36430" /db_xref="EnsemblGenomes-Tr:CAB15660" /db_xref="SubtiList:BG11984" /db_xref="UniProtKB/Swiss-Prot:O32276" /translation="MGIFHKLTFKTIQRRSGIMNDSLQNTDLISHFSHPF*" /label="usd CDS" gene complement(3399831..3399941) /gene="usd" /locus_tag="BSU_36430" /old_locus_tag="BSU36430" /label="usd gene" promotor_-10 complement(3399972..3399990) /Source="Nicolas_upshift_promotors" /id="U2855" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1092 /SigmaFactorBS="atctgaaaaagttcgtttcaccccttgtccttattgagtttt tAGCATAttcccaaaagaatgcTAATACACTGTTACAAACCtaacaaagagagtgttt g" /listShort="usd, spoIIID, S1405, mbl" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3399994) /Source="Nicolas_upshifts" /id="U2855" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1092 /SigmaFactorBS="atctgaaaaagttcgtttcaccccttgtccttattgagtttt tAGCATAttcccaaaagaatgcTAATACACTGTTACAAACCtaacaaagagagtgttt g" /listShort="usd, spoIIID, S1405, mbl" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3400006..3400011) /Source="Nicolas_upshift_promotors" /id="U2855" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1092 /SigmaFactorBS="atctgaaaaagttcgtttcaccccttgtccttattgagtttt tAGCATAttcccaaaagaatgcTAATACACTGTTACAAACCtaacaaagagagtgttt g" /listShort="usd, spoIIID, S1405, mbl" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3400087..3400093 /Source="Nicolas_upshift_promotors" /id="U2856" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.347652347652348" /psig="0.98001998001998" /xcortree=305 /SigmaFactorBS="ctatttcgcgtcactaaattttcaTCTTTACaactattgatc gcTCCTGTAAAATGAAATAAGCaattagttacttaggtaagttttttagaaggagacc g" /listShort="ywoH, ywoG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3400107..3400126 /Source="Nicolas_upshift_promotors" /id="U2856" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.347652347652348" /psig="0.98001998001998" /xcortree=305 /SigmaFactorBS="ctatttcgcgtcactaaattttcaTCTTTACaactattgatc gcTCCTGTAAAATGAAATAAGCaattagttacttaggtaagttttttagaaggagacc g" /listShort="ywoH, ywoG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3400123 /Source="Nicolas_upshifts" /id="U2856" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.347652347652348" /psig="0.98001998001998" /xcortree=305 /SigmaFactorBS="ctatttcgcgtcactaaattttcaTCTTTACaactattgatc gcTCCTGTAAAATGAAATAAGCaattagttacttaggtaagttttttagaaggagacc g" /listShort="ywoH, ywoG" /GFF_Attribute="listLong" /label="upshifts" CDS 3400166..3400579 /gene="ywoH" /locus_tag="BSU_36440" /old_locus_tag="BSU36440" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MarR family)" /protein_id="NP_391525.1" /db_xref="EnsemblGenomes-Gn:BSU36440" /db_xref="EnsemblGenomes-Tr:CAB15661" /db_xref="GOA:P94578" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12495" /db_xref="UniProtKB/Swiss-Prot:P94578" /translation="MSYVNRHLIHQINQSARLIAKKANEQLEPFGLYSSQWSVLYCLR TIGPMTQKEIWSYLNVEAPTVTRTIKRLEENGWVQRRQGEDKREKLVVLTKEAEKKYE EINVKMLKFEEELLADFRDEDKEAFSHLFRMFLQQ*" /label="ywoH CDS" gene 3400166..3400579 /gene="ywoH" /locus_tag="BSU_36440" /old_locus_tag="BSU36440" /label="ywoH gene" CDS 3400601..3401791 /gene="ywoG" /locus_tag="BSU_36450" /old_locus_tag="BSU36450" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_391526.1" /db_xref="EnsemblGenomes-Gn:BSU36450" /db_xref="EnsemblGenomes-Tr:CAB15662" /db_xref="GOA:P94577" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12494" /db_xref="UniProtKB/Swiss-Prot:P94577" /translation="MKKADAIWTKDFIMVLLVNLFVFVFFYTFLTVLPIYTLQELGGT ESQGGLLISLFLLSAIITRPFSGAIVERFGKKRMAIVSMALFALSSFLYMPIHNFSLL LGLRFFQGIWFSILTTVTGAIAADIIPAKRRGEGLGYFAMSMNLAMAIGPFLGLNLMR VVSFPVFFTAFALFMVAGLLVSFLIKVPQSKDSGTTVFRFAFSDMFEKGALKIATVGL FISFCYSTVTSYLSVFAKSVDLSDISGYFFVCFAVTMMIARPFTGKLFDKVGPGIVIY PSILIFSVGLCMLSFTHSGLMLLLSGAVIGLGYGSIVPCMQTLAIQKSPAHRSGFATA TFFTFFDSGIAVGSYVFGLFVASAGFSAIYLTAGLFVLIALLLYTWSQKKPAEAEGKV SIAE*" /label="ywoG CDS" gene 3400601..3401791 /gene="ywoG" /locus_tag="BSU_36450" /old_locus_tag="BSU36450" /label="ywoG gene" CDS complement(3401882..3403288) /gene="ywoF" /locus_tag="BSU_36460" /old_locus_tag="BSU36460" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15266115, 16607952, 23504016; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative pectin lyase" /protein_id="NP_391527.1" /db_xref="EnsemblGenomes-Gn:BSU36460" /db_xref="EnsemblGenomes-Tr:CAB15663" /db_xref="GOA:P94576" /db_xref="InterPro:IPR006626" /db_xref="InterPro:IPR006633" /db_xref="InterPro:IPR011050" /db_xref="InterPro:IPR012334" /db_xref="SubtiList:BG12493" /db_xref="UniProtKB/Swiss-Prot:P94576" /translation="MRKWYFILLAGVLTSVILAFVYDKTKANEEGSGDYLYVSPNGSD QNEGTKEKPFRTLAHASEKAAAGTTVMIREGTYHETLDVKHSGTDGKPITFRNYENEN VVISGESVANAEYETPLIRIHDKHDIAISGLTIQDLSVSSEEATAIGIYVSGSSSHIA IKDNHIRGIKTTADEGNAHGIAVYGTGSMKDIRIEDNTVEKLTLGASEAVVLNGNIDG FTVAGNVVRNNNNIGIDLIGYEGTADKNDYVRNGVVENNTVYQNSTYGNPAYGDEYSA GGIYVDGGHDIEIKNNTVYDNDIGIEATSEHKGKYANAIQITDNKVYNNAYTGISIGG YDKKRGGTSNSLIARNIMYRNDTKGLYGGQLLLQYDTKNNTIEKNILTAGDSRLFIGN DFTENEGNTVNHNVYHKEADQDGIWMWKKKEYDSFSSYRKATKNDQQSIYADPMFRDE ASYDFSLDPDSPARPVIE*" /label="ywoF CDS" gene complement(3401882..3403288) /gene="ywoF" /locus_tag="BSU_36460" /old_locus_tag="BSU36460" /label="ywoF gene" downshifts complement(3402179) /Source="Nicolas_upshifts" /id="D1885" /incds=1 /nref=1 /ntot=78 /MaxReadThrough="5.28695" /MaxDrop="2.1962" /score="4.73902293" /energy="-22.3" /TU="U2857" /idTUdmin="U2857" /TUdmin="-924" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3403321..3403340) /Source="Nicolas_upshift_promotors" /id="U2857" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.756243756243756" /psig="0.997002997002997" /xcortree=2979 /SigmaFactorBS="gaataagatctatttagacggtatattttcatatttttgaaA TGGttttccataaatagAACATTTATAATGGTTTTAGaaatctattctaaaacgaaat g" /listShort="ywoF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3403339) /Source="Nicolas_upshifts" /id="U2857" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.756243756243756" /psig="0.997002997002997" /xcortree=2979 /SigmaFactorBS="gaataagatctatttagacggtatattttcatatttttgaaA TGGttttccataaatagAACATTTATAATGGTTTTAGaaatctattctaaaacgaaat g" /listShort="ywoF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3403355..3403358) /Source="Nicolas_upshift_promotors" /id="U2857" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.756243756243756" /psig="0.997002997002997" /xcortree=2979 /SigmaFactorBS="gaataagatctatttagacggtatattttcatatttttgaaA TGGttttccataaatagAACATTTATAATGGTTTTAGaaatctattctaaaacgaaat g" /listShort="ywoF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3403394..3404866) /gene="pucI" /locus_tag="BSU_36470" /old_locus_tag="BSU36470" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11344136, 12029039, 15849754, 16850406, 26967546" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11344136, 12029039, 15849754, 16850406, 26967546; Product type t : transporter" /codon_start=1 /transl_table=11 /product="allantoin permease" /protein_id="NP_391528.1" /db_xref="EnsemblGenomes-Gn:BSU36470" /db_xref="EnsemblGenomes-Tr:CAB15664" /db_xref="GOA:P94575" /db_xref="InterPro:IPR001248" /db_xref="InterPro:IPR012681" /db_xref="SubtiList:BG12492" /db_xref="UniProtKB/Swiss-Prot:P94575" /translation="MKLKESQQQSNRLSNEDLVPLGQEKRTWKAMNFASIWMGCIHNI PTYATVGGLIAIGLSPWQVLAIIITASLILFGALALNGHAGTKYGLPFPVIIRASYGI YGANIPALLRAFTAIMWLGIQTFAGSTALNILLLNMWPGWGEIGGEWNILGIHLSGLL SFVFFWAIHLLVLHHGMESIKRFEVWAGPLVYLVFGGMVWWAVDIAGGLGPIYSQPGK FHTFSETFWPFAAGVTGIIGIWATLILNIPDFTRFAETQKEQIKGQFYGLPGTFALFA FASITVTSGSQVAFGEPIWDVVDILARFDNPYVIVLSVITLCIATISVNVAANIVSPA YDIANALPKYINFKRGSFITALLALFTVPWKLMESATSVYAFLGLIGGMLGPVAGVMM ADYFIIRKRELSVDDLYSETGRYVYWKGYNYRAFAATMLGALISLIGMYVPVLKSLYD ISWFVGVLISFLFYIVLMRVHPPASLAIETVEHAQVRQAE*" /label="pucI CDS" gene complement(3403394..3404866) /gene="pucI" /locus_tag="BSU_36470" /old_locus_tag="BSU36470" /label="pucI gene" CDS complement(3405047..3406405) /gene="ywoD" /locus_tag="BSU_36480" /old_locus_tag="BSU36480" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_391529.1" /db_xref="EnsemblGenomes-Gn:BSU36480" /db_xref="EnsemblGenomes-Tr:CAB15665" /db_xref="GOA:P94574" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12491" /db_xref="UniProtKB/Swiss-Prot:P94574" /translation="MLSKKSRAVFLTAVASGTMLNPLNSSMISLALHSIQHEFHLSFT TVSWLISSFYLASAVAQPVTGKLGDLIGRKRLFLFGLILVAVSAIGAPFAPTFMTLLV MRLFQSVGSSAIYPSGVGLIRNHIHERQASALAVLSIFASAMTALGPTAGGFLIVWGG WPAIFIVNLPFIILSFLLGLYMFPKDQKKGAGIKTIIRQLDILGIVLFAGGIIFLLSF LLSFSTSPHAVEGVLGLLLLCAFVWRELKTDKPFIDVRLFKTQRNLSAVYVQFILLNV FFYCLFFGLPSYFQDEMHLSVQTSGLFMLFMSGMSIVVSPLTGKWIDRSGVVKPIFAG ALLMTAGAVLLTIFFINVQTIGKGLILSLLGIGYGLGNVALQAAMLETSPSNMVGTTS GLFQTCRYLGSILSSVILGILFGKEITAAHFDMMGIIMIIAGGASLLMAVRFAALMKT AS*" /label="ywoD CDS" gene complement(3405047..3406405) /gene="ywoD" /locus_tag="BSU_36480" /old_locus_tag="BSU36480" /label="ywoD gene" downshifts complement(3405061) /Source="Nicolas_upshifts" /id="D1886" /incds=0 /nref=58 /ntot=198 /MaxReadThrough="1.44148" /MaxDrop="4.13092" /score="20.2036192" /energy="-12.8" /TU="NA" /idTUdmin="U2858" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3406405..3406974) /gene="ywoC" /locus_tag="BSU_36490" /old_locus_tag="BSU36490" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme of isochorismatase family" /protein_id="NP_391530.2" /db_xref="EnsemblGenomes-Gn:BSU36490" /db_xref="EnsemblGenomes-Tr:CAB15666" /db_xref="GOA:P94573" /db_xref="InterPro:IPR000868" /db_xref="InterPro:IPR016291" /db_xref="InterPro:IPR036380" /db_xref="SubtiList:BG12490" /db_xref="UniProtKB/Swiss-Prot:P94573" /translation="MMNTLNIDFQKTALVIIDLQKGIVPIDQSGQVVPNAKKLVDEFR KHNGFISFVNVAFHDGADALKPQTDEPAQGGSGEMPADWAEFVPEIGVQDGDYTVTKR QWGAFFGTDLDLQLRRRGIDTIVLCGIATNIGVESTAREAFQLGYQQIFITDAMSTFS DEEHEATLRFIFPRIGKSRTTEEFLEQVK*" /label="ywoC CDS" gene complement(3406405..3406974) /gene="ywoC" /locus_tag="BSU_36490" /old_locus_tag="BSU36490" /label="ywoC gene" promotor_-10 complement(3406993..3407004) /Source="Nicolas_upshift_promotors" /id="U2858" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=804 /SigmaFactorBS="ccttctgagaatttcacaagcatcataaaagaacttaggcag tgtgaAGAGTAAaatatgcaatgtgAGAAACACTAACagtatcaggaggagacgtatg a" /listShort="ywoC, ywoD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3407011) /Source="Nicolas_upshifts" /id="U2858" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=804 /SigmaFactorBS="ccttctgagaatttcacaagcatcataaaagaacttaggcag tgtgaAGAGTAAaatatgcaatgtgAGAAACACTAACagtatcaggaggagacgtatg a" /listShort="ywoC, ywoD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3407018..3407024) /Source="Nicolas_upshift_promotors" /id="U2858" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=804 /SigmaFactorBS="ccttctgagaatttcacaagcatcataaaagaacttaggcag tgtgaAGAGTAAaatatgcaatgtgAGAAACACTAACagtatcaggaggagacgtatg a" /listShort="ywoC, ywoD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3407081..3407248) /locus_tag="BSU_36499" /old_locus_tag="BSU36499" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="PSEUDO:CCQ48605.1" /translation="MSYPALDGPPQIHGHFQAGTDRQQAGDEAMTPFMITVLAGLFVC TTCYYYIKEKS*" /label="hypothetical protein CDS" gene complement(3407081..3407248) /locus_tag="BSU_36499" /old_locus_tag="BSU36499" /pseudo /label="gene" CDS complement(3407158..3407622) /gene="ywoB" /locus_tag="BSU_36500" /old_locus_tag="BSU36500" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 21856850; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391531.1" /db_xref="EnsemblGenomes-Gn:BSU36500" /db_xref="EnsemblGenomes-Tr:CAB15667" /db_xref="GOA:P94572" /db_xref="InterPro:IPR020218" /db_xref="SubtiList:BG12489" /db_xref="UniProtKB/Swiss-Prot:P94572" /translation="MMNKGGRLRKAVRKSIPATFRLFLAFNFFVYGLAKVVIGQFGEV TPEIEAAAGKGFTIAWTFFGYSHVYELFIGFGEILAAVLLLIPRTAALGAVIFMPIIV NIVLINYCFDIGVQDLSTILMVMCLILLWMDRRKFMGIFRQEPIDSRQVMKR*" /label="ywoB CDS" gene complement(3407158..3407622) /gene="ywoB" /locus_tag="BSU_36500" /old_locus_tag="BSU36500" /label="ywoB gene" promotor_-10 complement(3407652..3407671) /Source="Nicolas_upshift_promotors" /id="U2859" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.736263736263736" /psig="0.999000999001" /xcortree=2195 /SigmaFactorBS="actattcatatgagctgaaaagggaATTGACATtaattagaa tactCTATACTGTATTAAGTGTACtacatcaaataatacactgagggggatgtatgat g" /listShort="ywoB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3407657) /Source="Nicolas_upshifts" /id="U2859" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.736263736263736" /psig="0.999000999001" /xcortree=2195 /SigmaFactorBS="actattcatatgagctgaaaagggaATTGACATtaattagaa tactCTATACTGTATTAAGTGTACtacatcaaataatacactgagggggatgtatgat g" /listShort="ywoB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3407685..3407692) /Source="Nicolas_upshift_promotors" /id="U2859" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.736263736263736" /psig="0.999000999001" /xcortree=2195 /SigmaFactorBS="actattcatatgagctgaaaagggaATTGACATtaattagaa tactCTATACTGTATTAAGTGTACtacatcaaataatacactgagggggatgtatgat g" /listShort="ywoB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3407823..3407826 /Source="Nicolas_upshift_promotors" /id="U2860" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.835164835164835" /psig="0.978021978021978" /xcortree=320 /SigmaFactorBS="acatttctcaaaaaccatgtcaggaaatcttacatgaaAATG ttttatcattctttTTTCTCTATAATGAAGAAATataataattgctttttattctgaa a" /listShort="amtB, glnK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3407841..3407860 /Source="Nicolas_upshift_promotors" /id="U2860" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.835164835164835" /psig="0.978021978021978" /xcortree=320 /SigmaFactorBS="acatttctcaaaaaccatgtcaggaaatcttacatgaaAATG ttttatcattctttTTTCTCTATAATGAAGAAATataataattgctttttattctgaa a" /listShort="amtB, glnK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3407845 /Source="Nicolas_upshifts" /id="U2860" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.835164835164835" /psig="0.978021978021978" /xcortree=320 /SigmaFactorBS="acatttctcaaaaaccatgtcaggaaatcttacatgaaAATG ttttatcattctttTTTCTCTATAATGAAGAAATataataattgctttttattctgaa a" /listShort="amtB, glnK" /GFF_Attribute="listLong" /label="upshifts" CDS 3407904..3409118 /gene="amtB" /locus_tag="BSU_36510" /old_locus_tag="BSU36510" /function="16.1: Circulate" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14600241, 15849754, 16850406, 17001076, 21435182" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14600241, 15849754, 16850406, 17001076, 21435182; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ammonium transporter" /protein_id="NP_391532.1" /db_xref="EnsemblGenomes-Gn:BSU36510" /db_xref="EnsemblGenomes-Tr:CAB15668" /db_xref="GOA:Q07429" /db_xref="InterPro:IPR001905" /db_xref="InterPro:IPR018047" /db_xref="InterPro:IPR024041" /db_xref="InterPro:IPR029020" /db_xref="SubtiList:BG10869" /db_xref="UniProtKB/Swiss-Prot:Q07429" /translation="MQMGDTVFMFFCALLVWLMTPGLALFYGGMVKSKNVLSTAMHSF SSIAIVSIVWVLFGYTLAFAPGNSIIGGLEWAGLKGVGFDPGDYSDTIPHSLFMMFQM TFAVLTTAIISGAFAERMRFGAFLLFSVLWASLVYTPVAHWVWGGGWIGQLGALDFAG GNVVHISSGVAGLVLAIVLGKRKDGTASSPHNLIYTFLGGALIWFGWFGFNVGSALTL DGVAMYAFINTNTAAAAGIAGWILVEWIINKKPTMLGAVSGAIAGLVAITPAAGFVTP FASIIIGIIGGAVCFWGVFSLKKKFGYDDALDAFGLHGIGGTWGGIATGLFATTSVNS AGADGLFYGDASLIWKQIVAIAATYVFVFIVTFVIIKIVSLFLPLRATEEEESLGLDL TMHGEKAYQDSM*" /label="amtB CDS" gene 3407904..3409118 /gene="amtB" /locus_tag="BSU_36510" /old_locus_tag="BSU36510" /label="amtB gene" promotor_-10 complement(3408734..3408752) /Source="Nicolas_upshift_promotors" /id="U2861" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2846 /SigmaFactorBS="taagcgagaatactccccagaaACAAACAGctccgccgatga tGCCGATAATAATGGAAGCGaacggtgtgacaaatccggcagccggcgtaatggcgac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3408735) /Source="Nicolas_upshifts" /id="U2861" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2846 /SigmaFactorBS="taagcgagaatactccccagaaACAAACAGctccgccgatga tGCCGATAATAATGGAAGCGaacggtgtgacaaatccggcagccggcgtaatggcgac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3408766..3408773) /Source="Nicolas_upshift_promotors" /id="U2861" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2846 /SigmaFactorBS="taagcgagaatactccccagaaACAAACAGctccgccgatga tGCCGATAATAATGGAAGCGaacggtgtgacaaatccggcagccggcgtaatggcgac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3408984..3408990 /Source="Nicolas_upshift_promotors" /id="U2862" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.344655344655345" /psig="0.993006993006993" /xcortree=610 /SigmaFactorBS="tctggaaacaaatcgtcgccatcgccgccacttatgttTTTG TATttattgtcactttCGTTATTATTAAAATTGTAAgcctcttccttccccttcgcgc a" /listShort="glnK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3409004..3409023 /Source="Nicolas_upshift_promotors" /id="U2862" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.344655344655345" /psig="0.993006993006993" /xcortree=610 /SigmaFactorBS="tctggaaacaaatcgtcgccatcgccgccacttatgttTTTG TATttattgtcactttCGTTATTATTAAAATTGTAAgcctcttccttccccttcgcgc a" /listShort="glnK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3409006 /Source="Nicolas_upshifts" /id="U2862" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.344655344655345" /psig="0.993006993006993" /xcortree=610 /SigmaFactorBS="tctggaaacaaatcgtcgccatcgccgccacttatgttTTTG TATttattgtcactttCGTTATTATTAAAATTGTAAgcctcttccttccccttcgcgc a" /listShort="glnK" /GFF_Attribute="listLong" /label="upshifts" CDS 3409130..3409480 /gene="glnK" /locus_tag="BSU_36520" /old_locus_tag="BSU36520" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:14600241, 17001076, 21435182, 23461034, 25691471" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14600241, 17001076, 21435182, 23461034, 25691471; Product type r: regulator" /codon_start=1 /transl_table=11 /product="nitrogen-regulated PII-like regulator protein" /protein_id="NP_391533.1" /db_xref="EnsemblGenomes-Gn:BSU36520" /db_xref="EnsemblGenomes-Tr:CAB15669" /db_xref="GOA:Q07428" /db_xref="InterPro:IPR002187" /db_xref="InterPro:IPR011322" /db_xref="InterPro:IPR015867" /db_xref="InterPro:IPR017918" /db_xref="PDB:4R25" /db_xref="PDB:4RX6" /db_xref="SubtiList:BG10870" /db_xref="UniProtKB/Swiss-Prot:Q07428" /translation="MSGQMFKVEIVTRPANFEKLKQELGKIGVTSLTFSNVHGCGLQK AHTELYRGVKIESNVYERLKIEIVVSKVPVDQVTETAKRVLKTGSPGDGKIFVYEISN TINIRTGEEGPEAL*" /label="glnK CDS" gene 3409130..3409480 /gene="glnK" /locus_tag="BSU_36520" /old_locus_tag="BSU36520" /label="glnK gene" downshifts 3409473 /Source="Nicolas_upshifts" /id="D1887" /incds=0 /nref=179 /ntot=251 /MaxReadThrough="2.13701" /MaxDrop="8.63831" /score="25.582072" /energy="-12.5" /TU="NA" /idTUdmin="U2860" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 3409532..3409540 /Source="Nicolas_upshift_promotors" /id="U2863" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp=1 /psig=1 /xcortree=1773 /SigmaFactorBS="actccggatctctttttttgtgcacagaatcCCCCCAGAAac cgcgattcctcTTCGAATTCtcttcaagcgccgttatttcagacaatctctattttta t" /listShort="bcrC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3409554..3409562 /Source="Nicolas_upshift_promotors" /id="U2863" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp=1 /psig=1 /xcortree=1773 /SigmaFactorBS="actccggatctctttttttgtgcacagaatcCCCCCAGAAac cgcgattcctcTTCGAATTCtcttcaagcgccgttatttcagacaatctctattttta t" /listShort="bcrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3409561 /Source="Nicolas_upshifts" /id="U2863" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp=1 /psig=1 /xcortree=1773 /SigmaFactorBS="actccggatctctttttttgtgcacagaatcCCCCCAGAAac cgcgattcctcTTCGAATTCtcttcaagcgccgttatttcagacaatctctattttta t" /listShort="bcrC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3409603..3409612 /Source="Nicolas_upshift_promotors" /id="U2864" /multdbtbs="SigM,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1653 /SigmaFactorBS="agcgccgttatttcagacaatctctatttttattTGAAACTT TTcatgagtaagatTAGTCTACTAAATATAaaaatgtaaaaggtgattatttgaacta c" /listShort="bcrC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3409625..3409640 /Source="Nicolas_upshift_promotors" /id="U2864" /multdbtbs="SigM,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1653 /SigmaFactorBS="agcgccgttatttcagacaatctctatttttattTGAAACTT TTcatgagtaagatTAGTCTACTAAATATAaaaatgtaaaaggtgattatttgaacta c" /listShort="bcrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3409629 /Source="Nicolas_upshifts" /id="U2864" /multdbtbs="SigM,SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1653 /SigmaFactorBS="agcgccgttatttcagacaatctctatttttattTGAAACTT TTcatgagtaagatTAGTCTACTAAATATAaaaatgtaaaaggtgattatttgaacta c" /listShort="bcrC" /GFF_Attribute="listLong" /label="upshifts" CDS 3409661..3410242 /gene="bcrC" /locus_tag="BSU_36530" /old_locus_tag="BSU36530" /EC_number="3.6.1.27" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12486040, 14612242, 15838020, 15849754, 15946938, 16850406, 27528508" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12486040, 14612242, 15838020, 15849754, 15946938, 16850406, 27528508; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="undecaprenyl pyrophosphate phosphatase (bacitracin resistance)" /protein_id="NP_391534.1" /db_xref="EnsemblGenomes-Gn:BSU36530" /db_xref="EnsemblGenomes-Tr:CAB15670" /db_xref="GOA:P94571" /db_xref="InterPro:IPR000326" /db_xref="InterPro:IPR033879" /db_xref="InterPro:IPR036938" /db_xref="SubtiList:BG12488" /db_xref="UniProtKB/Swiss-Prot:P94571" /translation="MNYEIFKAIHGLSHHNSVLDSIMVFITEYAIVAYALILLAIWLF GNTQSRKHVLYAGITGIAGLVINYLITLVYFEPRPFVAHTVHTLIPHAADASFPSDHT TGALAISIAMLFRNRKIGWPLVIFGLLTGFSRIWVGHHYPVDVLGSLVVAIIIGFLFF RFSDLLRPFVDLVVRIYEAIINKLTKKPTDQNF*" /label="bcrC CDS" gene 3409661..3410242 /gene="bcrC" /locus_tag="BSU_36530" /old_locus_tag="BSU36530" /label="bcrC gene" promotor_-10 complement(3409759..3409778) /Source="Nicolas_upshift_promotors" /id="U2865" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.793206793206793" /psig="0.793206793206793" /xcortree=1382 /SigmaFactorBS="ctgcgtatagcacatgttttctgctttgtGTGTTCCCAaaca gccagattgCCAATAGGATAAGGGCATAGgcgacaatggcatattccgtgatgaagac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3409769) /Source="Nicolas_upshifts" /id="U2865" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.793206793206793" /psig="0.793206793206793" /xcortree=1382 /SigmaFactorBS="ctgcgtatagcacatgttttctgctttgtGTGTTCCCAaaca gccagattgCCAATAGGATAAGGGCATAGgcgacaatggcatattccgtgatgaagac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3409792..3409800) /Source="Nicolas_upshift_promotors" /id="U2865" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.793206793206793" /psig="0.793206793206793" /xcortree=1382 /SigmaFactorBS="ctgcgtatagcacatgttttctgctttgtGTGTTCCCAaaca gccagattgCCAATAGGATAAGGGCATAGgcgacaatggcatattccgtgatgaagac c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3410223 /Source="Nicolas_upshifts" /id="D1888" /incds=0 /nref=192 /ntot=251 /MaxReadThrough="2.1929" /MaxDrop="6.53316" /score="25.582072" /energy="-12.5" /TU="NA" /idTUdmin="U2863" /TUdmin=2 /isTUend="TRUE" /label="downshifts" CDS complement(3410283..3410705) /gene="ywnJ" /locus_tag="BSU_36540" /old_locus_tag="BSU36540" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14762009, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391535.1" /db_xref="EnsemblGenomes-Gn:BSU36540" /db_xref="EnsemblGenomes-Tr:CAB15671" /db_xref="GOA:P71045" /db_xref="InterPro:IPR006976" /db_xref="SubtiList:BG12487" /db_xref="UniProtKB/Swiss-Prot:P71045" /translation="MNRLLLAGWIFFILLSVCTESFSGMVVSQTVAFHFQPHPDLSQF LVMDFTELTVPEAFIQKIGHAFSFFVLTYLLWKQRGSIRSAAAGSFAFAFFTEVLQLF FSRNGCIRDVLIDAVGIGLFYGLYVLAKRRKQEMYEKY*" /label="ywnJ CDS" gene complement(3410283..3410705) /gene="ywnJ" /locus_tag="BSU_36540" /old_locus_tag="BSU36540" /label="ywnJ gene" downshifts complement(3410302) /Source="Nicolas_upshifts" /id="D1889" /incds=0 /nref=9 /ntot=75 /MaxReadThrough="0.80227" /MaxDrop="3.65224" /score="4.98901321" /energy="-13.6" /TU="NA" /idTUdmin="U2869" /TUdmin=215 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3410740..3410755) /Source="Nicolas_upshift_promotors" /id="U2866" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1654 /SigmaFactorBS="ttaatgaagaaaacgtctatccttgtgatgggcgtttttttc TGTTACTTTTtgctttgttttaCCGTCTATGTAGTTACatgtaggcacgtacgttata a" /listShort="ywnJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3410759) /Source="Nicolas_upshifts" /id="U2866" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1654 /SigmaFactorBS="ttaatgaagaaaacgtctatccttgtgatgggcgtttttttc TGTTACTTTTtgctttgttttaCCGTCTATGTAGTTACatgtaggcacgtacgttata a" /listShort="ywnJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3410768..3410777) /Source="Nicolas_upshift_promotors" /id="U2866" /multdbtbs="SigW,SigX" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1654 /SigmaFactorBS="ttaatgaagaaaacgtctatccttgtgatgggcgtttttttc TGTTACTTTTtgctttgttttaCCGTCTATGTAGTTACatgtaggcacgtacgttata a" /listShort="ywnJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3410816..3411667) /gene="spoIIQ" /locus_tag="BSU_36550" /old_locus_tag="BSU36550" /function="16.8: Protect" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16164552, 16959571, 17121846, 18077456, 21097616, 23859254, 26929302, 27381174, 28784753" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16164552, 16959571, 17121846, 18077456, 21097616, 23859254, 26929302, 27381174, 28784753; Product type f: factor" /codon_start=1 /transl_table=11 /product="forespore protein required for alternative engulfment" /protein_id="NP_391536.1" /db_xref="EnsemblGenomes-Gn:BSU36550" /db_xref="EnsemblGenomes-Tr:CAB15672" /db_xref="GOA:P71044" /db_xref="InterPro:IPR011055" /db_xref="InterPro:IPR016047" /db_xref="PDB:3TUF" /db_xref="PDB:3UZ0" /db_xref="SubtiList:BG11978" /db_xref="UniProtKB/Swiss-Prot:P71044" /translation="MREEEKKTSQVKKLQQFFRKRWVFPAIYLVSAAVILTAVLWYQS VSNDEVKDQLADNGGNSAYDNNDDAVEVGKSMENVAMPVVDSENVSVVKKFYETDAAK EEKEAALVTYNNTYSLSKGIDLAEKDGKDFDVSASLSGTVVKAEKDPVLGYVVEVEHA DGLSTVYQSLSEVSVEQGDKVKQNQVIGKSGKNLYSEDSGNHVHFEIRKDGVAMNPLN FMDKPVSSIEKAATQETEESIQQSSEKKDGSTEKGTEEKSGEKKDDSTDKSGSKESST TEDTEQS*" /label="spoIIQ CDS" gene complement(3410816..3411667) /gene="spoIIQ" /locus_tag="BSU_36550" /old_locus_tag="BSU36550" /label="spoIIQ gene" downshifts complement(3410825) /Source="Nicolas_upshifts" /id="D1890" /incds=0 /nref=19 /ntot=51 /MaxReadThrough="3.592" /MaxDrop="5.16472" /score="11.9597238" /energy="-7.1" /TU="U2869" /idTUdmin="U2866" /TUdmin="-176" /isTUend="FALSE" /label="downshifts" downshifts complement(3411067) /Source="Nicolas_upshifts" /id="D1891" /incds=1 /nref=4 /ntot=59 /MaxReadThrough="6.6416" /MaxDrop="3.0034" /score="11.9597238" /energy="-7.1" /TU="U2869" /idTUdmin="U2866" /TUdmin="-418" /isTUend="FALSE" /label="downshifts" promotor_-35 3411304..3411306 /Source="Nicolas_upshift_promotors" /id="U2867" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.578421578421578" /psig="0.999000999001" /xcortree=2749 /SigmaFactorBS="gagacatcgaaatcttttccgtctttctcagctaagtcaaTT CctttgcttaggctgtaCGTGTTATTATAGGTAACGAgtgctgcttctttctcttctt t" /listShort="S1406, S1407, ywnH, ywnG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3411323..3411342 /Source="Nicolas_upshift_promotors" /id="U2867" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.578421578421578" /psig="0.999000999001" /xcortree=2749 /SigmaFactorBS="gagacatcgaaatcttttccgtctttctcagctaagtcaaTT CctttgcttaggctgtaCGTGTTATTATAGGTAACGAgtgctgcttctttctcttctt t" /listShort="S1406, S1407, ywnH, ywnG" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3411324..3411670 /Source="Nicolas_S_feature" /locus_tag="new_3760210_3760556" /HighExp="LBGstat, LBGtran, Cold, Sw, dia15, C30, G180, Lbexp, LBGexp, UNK1" /AntisenseName="spoIIQ" /AntisenseCor="-0.81767802234568998" /AntisenseRegPval="-65.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1406" upshifts 3411324 /Source="Nicolas_upshifts" /id="U2867" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.578421578421578" /psig="0.999000999001" /xcortree=2749 /SigmaFactorBS="gagacatcgaaatcttttccgtctttctcagctaagtcaaTT CctttgcttaggctgtaCGTGTTATTATAGGTAACGAgtgctgcttctttctcttctt t" /listShort="S1406, S1407, ywnH, ywnG" /GFF_Attribute="listLong" /label="upshifts" misc_feature 3411662..3411665 /Source="Nicolas_upshift_promotors" /id="U2868" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.27972027972028" /psig="0.121878121878122" /xcortree=579 /SigmaFactorBS="cgaaaaaactgctgaagttttttgacttgagaagttttcttt tcttcctcTCTCattgtttcatcacctcagcaacattctgaacacttttctgaaaata t" /listShort="S1407, ywnH, ywnG" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 3411672..3411807 /Source="Nicolas_S_feature" /locus_tag="new_3760558_3760693" /HighExp="LBGstat, S8, LBGtran, Sw, LoTm, BC, Cold, S7, C30, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.122, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1407" upshifts 3411672 /Source="Nicolas_upshifts" /id="U2868" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.27972027972028" /psig="0.121878121878122" /xcortree=579 /SigmaFactorBS="cgaaaaaactgctgaagttttttgacttgagaagttttcttt tcttcctcTCTCattgtttcatcacctcagcaacattctgaacacttttctgaaaata t" /listShort="S1407, ywnH, ywnG" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(3411701) /Source="Nicolas_upshifts" /id="U2869" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.933066933066933" /psig="0.933066933066933" /xcortree=974 /SigmaFactorBS="tcagtctgtgcaaactacatctaaaaaagtttttttggatag gttGTATATATTTtcagaaaagtgttcagaatgttgctgaggtgatgaaacaatgaga g" /listShort="spoIIQ, ywnJ" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(3411707..3411716) /Source="Nicolas_upshift_promotors" /id="U2869" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.933066933066933" /psig="0.933066933066933" /xcortree=974 /SigmaFactorBS="tcagtctgtgcaaactacatctaaaaaagtttttttggatag gttGTATATATTTtcagaaaagtgttcagaatgttgctgaggtgatgaaacaatgaga g" /listShort="spoIIQ, ywnJ" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 3411808..3412299 /gene="ywnH" /locus_tag="BSU_36560" /old_locus_tag="BSU36560" /EC_number="2.3.1.183" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12793527, 16021622, 27694229; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aminoacid analogs (phosphinothricin) N-acetyltransferase" /protein_id="NP_391537.1" /db_xref="EnsemblGenomes-Gn:BSU36560" /db_xref="EnsemblGenomes-Tr:CAB15673" /db_xref="GOA:P71043" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="PDB:1VHS" /db_xref="SubtiList:BG12486" /db_xref="UniProtKB/Swiss-Prot:P71043" /translation="MTLRLAEHRDLEAVVAIYNSTIASRMVTADTEPVTPEDRMEWFS GHTESRPLYVAEDENGNVAAWISFETFYGRPAYNKTAEVSIYIDEACRGKGVGSYLLQ EALRIAPNLGIRSLMAFIFGHNKPSLKLFEKHGFAEWGLFPGIAEMDGKRYDLKILGR ELS*" /label="ywnH CDS" gene 3411808..3412299 /gene="ywnH" /locus_tag="BSU_36560" /old_locus_tag="BSU36560" /label="ywnH gene" promotor_-35 3412037..3412042 /Source="Nicolas_upshift_promotors" /id="U2870" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1178 /SigmaFactorBS="tttgaaacattttatggaaggccagcctATAATAaaacagcg gaagtcaGCATATACATTGACGAAGCatgccgcggcaaaggtgttggatcatatttgc t" /listShort="ywnG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3412058..3412076 /Source="Nicolas_upshift_promotors" /id="U2870" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1178 /SigmaFactorBS="tttgaaacattttatggaaggccagcctATAATAaaacagcg gaagtcaGCATATACATTGACGAAGCatgccgcggcaaaggtgttggatcatatttgc t" /listShort="ywnG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3412069 /Source="Nicolas_upshifts" /id="U2870" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1178 /SigmaFactorBS="tttgaaacattttatggaaggccagcctATAATAaaacagcg gaagtcaGCATATACATTGACGAAGCatgccgcggcaaaggtgttggatcatatttgc t" /listShort="ywnG" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3412160..3413068) /Source="Nicolas_S_feature" /locus_tag="new_3761046_3761954_c" /HighExp="H2O2, dia15, Diami, dia5, S8, Paraq, G180, G135, C30, G150" /AntisenseName="ywnG" /AntisenseCor="0.27407310266030799" /AntisenseRegPval="-5.3" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.946" /TUlongSig="NA" /TUlongPSig="NA" /label="S1408" CDS 3412296..3412814 /gene="ywnG" /locus_tag="BSU_36570" /old_locus_tag="BSU36570" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22226636; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391538.1" /db_xref="EnsemblGenomes-Gn:BSU36570" /db_xref="EnsemblGenomes-Tr:CAB15674" /db_xref="GOA:P71042" /db_xref="InterPro:IPR035287" /db_xref="SubtiList:BG12485" /db_xref="UniProtKB/Swiss-Prot:P71042" /translation="MISLDKDENEIEHHNEENSLVEQETAPVGQESRQLSASAVKSLS DIAKWGKISGILLIIMGSLVTLSVLMTVIGAIPGVLLIISGVFLMRSAKAAAEAEGNL TGSAGESMLENYGTFIKMQLFYAASSIVTVLIGIIVAIFVLVVIGIAAFENTPSYDDP DSYYYEDDPVFE*" /label="ywnG CDS" gene 3412296..3412814 /gene="ywnG" /locus_tag="BSU_36570" /old_locus_tag="BSU36570" /label="ywnG gene" downshifts 3412619 /Source="Nicolas_upshifts" /id="D1892" /incds=1 /nref=1 /ntot=29 /MaxReadThrough="4.194" /MaxDrop="1.82458" /score="-3.39058903" /energy="-13.3" /TU="U2867,U2868,U2870" /idTUdmin="U2868" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" downshifts 3412817 /Source="Nicolas_upshifts" /id="D1893" /incds=0 /nref=3 /ntot=133 /MaxReadThrough="2.87136" /MaxDrop="2.9486" /score="-3.39058903" /energy="-13.3" /TU="U2867" /idTUdmin="U2870" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 3412973..3413104 /locus_tag="BSU_36575" /old_locus_tag="BSU36575" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514007.1" /translation="MNIKKTDEVGINPKPHFLFRVSACKKTHPDRLENLNNPGADLL* " /label="hypothetical protein CDS" gene 3412973..3413104 /locus_tag="BSU_36575" /old_locus_tag="BSU36575" /label="gene" CDS complement(3413101..3413535) /gene="ywnF" /locus_tag="BSU_36580" /old_locus_tag="BSU36580" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391539.1" /db_xref="EnsemblGenomes-Gn:BSU36580" /db_xref="EnsemblGenomes-Tr:CAB15675" /db_xref="GOA:P71041" /db_xref="InterPro:IPR020205" /db_xref="SubtiList:BG12484" /db_xref="UniProtKB/Swiss-Prot:P71041" /translation="MNFYRVEQMPGFIKTEMQKIQKAVQPFMKKTVIYRFLAIPLAAF SLFNLAAFLFHASADRESLISAGIFALLAALGLAFFKEAGYQHKQIQKTVHIYMLNRI KKSEILSEERKSSYARQIKEEPFAMRSFVEFLTEEDRRKKMY*" /label="ywnF CDS" gene complement(3413101..3413535) /gene="ywnF" /locus_tag="BSU_36580" /old_locus_tag="BSU36580" /label="ywnF gene" downshifts complement(3413113) /Source="Nicolas_upshifts" /id="D1894" /incds=0 /nref=174 /ntot=254 /MaxReadThrough="4.22489" /MaxDrop="5.35802" /score="21.5198482" /energy="-21.3" /TU="U2871" /idTUdmin="U2873" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3413584..3413603) /Source="Nicolas_upshift_promotors" /id="U2871" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.887112887112887" /psig="0.946053946053946" /xcortree=631 /SigmaFactorBS="attcttcgtgaaaaatacgggcagatTTCTTTAAaaccagct tgcaccTGCGTTAAAATAAACACATAtgataacgttcgtgaagcttgaaacatcaaat a" /listShort="ywnF, S1408" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3413591) /Source="Nicolas_upshifts" /id="U2871" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.887112887112887" /psig="0.946053946053946" /xcortree=631 /SigmaFactorBS="attcttcgtgaaaaatacgggcagatTTCTTTAAaaccagct tgcaccTGCGTTAAAATAAACACATAtgataacgttcgtgaagcttgaaacatcaaat a" /listShort="ywnF, S1408" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3413593..3413890) /Source="Nicolas_S_feature" /locus_tag="new_3762479_3762776_c" /HighExp="Etha, S6, S3, S4, S8, S5, S7, M9-stat, Sw, Salt" /AntisenseName="clsA" /AntisenseCor="-0.16109419145114601" /AntisenseRegPval="-2.1" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigEF" /TUshortPSig="0.99, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1409" promotor_-35 complement(3413618..3413625) /Source="Nicolas_upshift_promotors" /id="U2871" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.887112887112887" /psig="0.946053946053946" /xcortree=631 /SigmaFactorBS="attcttcgtgaaaaatacgggcagatTTCTTTAAaaccagct tgcaccTGCGTTAAAATAAACACATAtgataacgttcgtgaagcttgaaacatcaaat a" /listShort="ywnF, S1408" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3413664..3413668 /Source="Nicolas_upshift_promotors" /id="U2872" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=1840 /SigmaFactorBS="ttttcacgaagaatctggatcgccgcTCTTTattcttttaaa atgtgAGTGTTATAATTTGTAATGGgaatcagatcactgttattcatggaatactaat g" /listShort="S1410, clsA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3413685..3413704 /Source="Nicolas_upshift_promotors" /id="U2872" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=1840 /SigmaFactorBS="ttttcacgaagaatctggatcgccgcTCTTTattcttttaaa atgtgAGTGTTATAATTTGTAATGGgaatcagatcactgttattcatggaatactaat g" /listShort="S1410, clsA" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3413697..3413777 /Source="Nicolas_S_feature" /locus_tag="new_3762583_3762663" /HighExp="LBGstat, Diami, dia15, G180, Oxctl, H2O2, T0.30H, S8, Paraq, G135" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1410" upshifts 3413698 /Source="Nicolas_upshifts" /id="U2872" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=1840 /SigmaFactorBS="ttttcacgaagaatctggatcgccgcTCTTTattcttttaaa atgtgAGTGTTATAATTTGTAATGGgaatcagatcactgttattcatggaatactaat g" /listShort="S1410, clsA" /GFF_Attribute="listLong" /label="upshifts" CDS 3413778..3415226 /gene="clsA" /locus_tag="BSU_36590" /old_locus_tag="BSU36590" /EC_number="2.7.8.-" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:14973018, 16755131, 18820022, 26708983" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14973018, 16755131, 18820022, 26708983; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cardiolipin synthase (major)" /protein_id="NP_391540.1" /db_xref="EnsemblGenomes-Gn:BSU36590" /db_xref="EnsemblGenomes-Tr:CAB15676" /db_xref="GOA:P71040" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR001736" /db_xref="InterPro:IPR022924" /db_xref="InterPro:IPR025202" /db_xref="InterPro:IPR027379" /db_xref="InterPro:IPR030874" /db_xref="SubtiList:BG12483" /db_xref="UniProtKB/Swiss-Prot:P71040" /translation="MSISSILLSLFFILNILLAIIVIFKERRDASASWAWLLVLFFIP VLGFILYLLFGHNLRRKHLFQWEDRKKIGIERLLKHQLEDLETKQFQFNNRATFDNKD LIYMLIMNNHAVFTEDNSVDVITDGRDKFQRLLSDISKAKDHIHLQYYIYKGDELGKK LRDALIQKAKEGVQVRVLYDELGSRTLRKKFFKELREAGGHVEVFFPSKLRPINLRLN YRNHRKLVIIDGMTGYVGGFNVGDEYLGLNPKFGYWRDTHIRLQGTAVHAIQTRFILD WNQASHHHTLTYIPNHFPDYGPKGNVGMQIVTSGPDSEWEQIKNGYIKMISNAKRSIL IQTPYFIPDASLLDALRIACLSGIDVNIMIPNKPDHAFVYWATLSYIGDLLKAGATVY IYDNGFIHAKTIVVDDEIASVGTANIDVRSFRLNFEVNAFIYDITIAKKLVSTFKEDL LVSRKFTYEEYLQRPLWIRIKESVSRLLSPIL*" /label="clsA CDS" gene 3413778..3415226 /gene="clsA" /locus_tag="BSU_36590" /old_locus_tag="BSU36590" /label="clsA gene" upshifts complement(3413890) /Source="Nicolas_upshifts" /id="U2873" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=743 /SigmaFactorBS="agattatggccgaataataAGTATAAaataaagcctaaaacG GGAATAAAGAAAAGAACAagcagccacgcccaagatgcactggcatcgcgccgttctt t" /listShort="S1409, ywnF" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3413891..3413909) /Source="Nicolas_upshift_promotors" /id="U2873" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=743 /SigmaFactorBS="agattatggccgaataataAGTATAAaataaagcctaaaacG GGAATAAAGAAAAGAACAagcagccacgcccaagatgcactggcatcgcgccgttctt t" /listShort="S1409, ywnF" /GFF_Attribute="listLong" /label="promotor_-10" S_feature complement(3413892..3414235) /Source="Nicolas_S_feature" /locus_tag="new_3762778_3763121_c" /HighExp="S6, S8, S4, S5, S7, S3, T5.0H, M9-stat, C30, T4.0H" /AntisenseName="clsA" /AntisenseCor="3.3648966966722899E-2" /AntisenseRegPval="-0.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1411" promotor_-35 complement(3413925..3413931) /Source="Nicolas_upshift_promotors" /id="U2873" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=743 /SigmaFactorBS="agattatggccgaataataAGTATAAaataaagcctaaaacG GGAATAAAGAAAAGAACAagcagccacgcccaagatgcactggcatcgcgccgttctt t" /listShort="S1409, ywnF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3414213..3414231) /Source="Nicolas_upshift_promotors" /id="U2874" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1084 /SigmaFactorBS="acaccttctttcgccttttggatgagagcgtcccgcaatttt tTGCCTAattcatcgcctttatAAATATAATACTGTAAATGgatatgatccttagcct t" /listShort="S1411, S1409, ywnF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3414235) /Source="Nicolas_upshifts" /id="U2874" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1084 /SigmaFactorBS="acaccttctttcgccttttggatgagagcgtcccgcaatttt tTGCCTAattcatcgcctttatAAATATAATACTGTAAATGgatatgatccttagcct t" /listShort="S1411, S1409, ywnF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3414247..3414252) /Source="Nicolas_upshift_promotors" /id="U2874" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1084 /SigmaFactorBS="acaccttctttcgccttttggatgagagcgtcccgcaatttt tTGCCTAattcatcgcctttatAAATATAATACTGTAAATGgatatgatccttagcct t" /listShort="S1411, S1409, ywnF" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3415215 /Source="Nicolas_upshifts" /id="D1895" /incds=0 /nref=6 /ntot=214 /MaxReadThrough="0.7051" /MaxDrop="4.44298" /score="26.7449315" /energy="-19.5" /TU="NA" /idTUdmin="U2872" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3415247..3416020) /gene="mta" /locus_tag="BSU_36600" /old_locus_tag="BSU36600" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10200972, 11581256, 18502870" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10200972, 11581256, 18502870; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator regulating efflux transporters synthesis (Fur-independent bacillibactin export)" /protein_id="NP_391541.1" /db_xref="EnsemblGenomes-Gn:BSU36600" /db_xref="EnsemblGenomes-Tr:CAB15677" /db_xref="GOA:P71039" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="InterPro:IPR012925" /db_xref="InterPro:IPR036244" /db_xref="PDB:1JBG" /db_xref="PDB:1R8D" /db_xref="SubtiList:BG12482" /db_xref="UniProtKB/Swiss-Prot:P71039" /translation="MKYQVKQVAEISGVSIRTLHHYDNIELLNPSALTDAGYRLYSDA DLERLQQILFFKEIGFRLDEIKEMLDHPNFDRKAALQSQKEILMKKKQRMDEMIQTID RTLLSVDGGETMNKRDLFAGLSMKDIEEHQQTYADEVRKLYGKEIAEETEKRTSAYSA DDWRTIMAEFDSIYRRIAARMKHGPDDAEIQAAVGAFRDHICQYHYDCTLDIFRGLGE VYITDERFTDSINQYGEGLAAFLREAIIIYCDHQENPRP*" /label="mta CDS" gene complement(3415247..3416020) /gene="mta" /locus_tag="BSU_36600" /old_locus_tag="BSU36600" /label="mta gene" downshifts complement(3415269) /Source="Nicolas_upshifts" /id="D1896" /incds=0 /nref=1 /ntot=54 /MaxReadThrough="0.46006" /MaxDrop="2.97389" /score="11.4339746" /energy="-19.5" /TU="NA" /idTUdmin="U2876" /TUdmin=1342 /isTUend="FALSE" /label="downshifts" promotor_-35 3416095..3416098 /Source="Nicolas_upshift_promotors" /id="U2875" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.85914085914086" /psig="0.982017982017982" /xcortree=2618 /SigmaFactorBS="caacgttagggtcaatccccaaaatgttattttctatATACa aaacttctcacaaaTAGTGTATAAAAGAAAAGTGagtatttttttgtaaaggggagcc a" /listShort="ywnC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3416114..3416133 /Source="Nicolas_upshift_promotors" /id="U2875" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.85914085914086" /psig="0.982017982017982" /xcortree=2618 /SigmaFactorBS="caacgttagggtcaatccccaaaatgttattttctatATACa aaacttctcacaaaTAGTGTATAAAAGAAAAGTGagtatttttttgtaaaggggagcc a" /listShort="ywnC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3416118 /Source="Nicolas_upshifts" /id="U2875" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.85914085914086" /psig="0.982017982017982" /xcortree=2618 /SigmaFactorBS="caacgttagggtcaatccccaaaatgttattttctatATACa aaacttctcacaaaTAGTGTATAAAAGAAAAGTGagtatttttttgtaaaggggagcc a" /listShort="ywnC" /GFF_Attribute="listLong" /label="upshifts" CDS 3416165..3416548 /gene="ywnC" /locus_tag="BSU_36610" /old_locus_tag="BSU36610" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391542.1" /db_xref="EnsemblGenomes-Gn:BSU36610" /db_xref="EnsemblGenomes-Tr:CAB15678" /db_xref="GOA:P71038" /db_xref="InterPro:IPR035287" /db_xref="SubtiList:BG12481" /db_xref="UniProtKB/Swiss-Prot:P71038" /translation="MNPETMNKTLISISKWGKATGILFIIMGAITALSGAFFFLIGAV PGVLQIISGIFLMRSAREAGQMAEHNSGQSEDLMLENYAKFVKMQGIYLIVSIAVSIL AIIAFFIFLMLGIADGLFSDTYSTY*" /label="ywnC CDS" gene 3416165..3416548 /gene="ywnC" /locus_tag="BSU_36610" /old_locus_tag="BSU36610" /label="ywnC gene" downshifts 3416535 /Source="Nicolas_upshifts" /id="D1897" /incds=0 /nref=60 /ntot=180 /MaxReadThrough="1.0319" /MaxDrop="4.45212" /score="35.5991488" /energy="-11.4" /TU="NA" /idTUdmin="U2875" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3416583..3417224) /gene="ywnB" /locus_tag="BSU_36620" /old_locus_tag="BSU36620" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391543.1" /db_xref="EnsemblGenomes-Gn:BSU36620" /db_xref="EnsemblGenomes-Tr:CAB15679" /db_xref="InterPro:IPR016040" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG12480" /db_xref="UniProtKB/Swiss-Prot:P71037" /translation="MKIGIIGASGKAGNEILKEAKKRGHEVTAIVRNASKVQEQDVAI LEKDVFELTAEDIKPFDAVVNAFGAAPGQEHLHVEAGRALISILKDAKHTRLLVVGGA GSLFVDEAKTTRLMDTPEFPKEYLPTASNQGENLKDLQQTDSISWTFLSPAAFFDPAG KRTGSYQKGKDNVIVNAKGDSYISYADYAIAVLDELEHPEHKNERFTVVSEAE*" /label="ywnB CDS" gene complement(3416583..3417224) /gene="ywnB" /locus_tag="BSU_36620" /old_locus_tag="BSU36620" /label="ywnB gene" downshifts complement(3416633) /Source="Nicolas_upshifts" /id="D1898" /incds=0 /nref=20 /ntot=170 /MaxReadThrough="3.62026" /MaxDrop="4.98934" /score="21.1363072" /energy="-11.4" /TU="U2876" /idTUdmin="U2876" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" CDS complement(3417292..3417693) /gene="ywnA" /locus_tag="BSU_36630" /old_locus_tag="BSU36630" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_391544.1" /db_xref="EnsemblGenomes-Gn:BSU36630" /db_xref="EnsemblGenomes-Tr:CAB15680" /db_xref="GOA:P71036" /db_xref="InterPro:IPR000944" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:1XD7" /db_xref="SubtiList:BG12479" /db_xref="UniProtKB/Swiss-Prot:P71036" /translation="MINSRLAVAIHILSLISMDEKTSSEIIADSVNTNPVVVRRMISL LKKADILTSRAGVPGASLKKDPADISLLEVYRAVQKQEELFAVHENPNPKCPVGKKIQ NALDETFESVQRAMENELASKSLKDVMNHLF*" /label="ywnA CDS" gene complement(3417292..3417693) /gene="ywnA" /locus_tag="BSU_36630" /old_locus_tag="BSU36630" /label="ywnA gene" promotor_-10 complement(3417742..3417761) /Source="Nicolas_upshift_promotors" /id="U2876" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.385614385614386" /psig="0.993006993006993" /xcortree=1847 /SigmaFactorBS="gtgcatccggccgttctattgactaaaaacgGTGCACaaaac ccatgtattTAGTGTATATTAGATGTTGAcaaacgaatcaaatgtaactattatagtt a" /listShort="ywnA, ywnB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3417752) /Source="Nicolas_upshifts" /id="U2876" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.385614385614386" /psig="0.993006993006993" /xcortree=1847 /SigmaFactorBS="gtgcatccggccgttctattgactaaaaacgGTGCACaaaac ccatgtattTAGTGTATATTAGATGTTGAcaaacgaatcaaatgtaactattatagtt a" /listShort="ywnA, ywnB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3417754..3417827) /Source="Nicolas_S_feature" /locus_tag="new_3766640_3766713_c" /HighExp="BT, Etha, S1, B60, LoTm, B36, S2, Glucon, Sw, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.18507799999999999" /TUshortSig="Sig-" /TUshortPSig="0.106" /TUlongSig="SigH, SigA, SigB, SigB" /TUlongPSig="1, 0.993, 1, 0.995" /label="S1412" promotor_-35 complement(3417776..3417781) /Source="Nicolas_upshift_promotors" /id="U2876" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.385614385614386" /psig="0.993006993006993" /xcortree=1847 /SigmaFactorBS="gtgcatccggccgttctattgactaaaaacgGTGCACaaaac ccatgtattTAGTGTATATTAGATGTTGAcaaacgaatcaaatgtaactattatagtt a" /listShort="ywnA, ywnB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3417828..3419537) /gene="ureC" /locus_tag="BSU_36640" /old_locus_tag="BSU36640" /EC_number="3.5.1.5" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9287005, 12401490, 16199586" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9287005, 12401490, 16199586; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="urease (alpha subunit)" /protein_id="NP_391545.1" /db_xref="EnsemblGenomes-Gn:BSU36640" /db_xref="EnsemblGenomes-Tr:CAB15681" /db_xref="GOA:P77837" /db_xref="InterPro:IPR005848" /db_xref="InterPro:IPR006680" /db_xref="InterPro:IPR011059" /db_xref="InterPro:IPR011612" /db_xref="InterPro:IPR017950" /db_xref="InterPro:IPR017951" /db_xref="InterPro:IPR029754" /db_xref="InterPro:IPR032466" /db_xref="SubtiList:BG11983" /db_xref="UniProtKB/Swiss-Prot:P77837" /translation="MKMSREEYAELFGPTTGDKIRLGDTDLWIEVEKDFTVYGEEMIF GGGKTIRDGMGQNGRITGKDGALDLVITNVVLLDYTGIVKADVGVKDGRIVGVGKSGN PDIMDGVDPHMVIGAGTEVISGEGKILTAGGVDTHIHFICPQQMEVALSSGVTTLLGG GTGPATGSKATTCTSGAWYMARMLEAAEEFPINVGFLGKGNASDKAPLIEQVEAGAIG LKLHEDWGTTPSAIKTCMEVVDEADIQVAIHTDTINEAGFLENTLDAIGDRVIHTYHI EGAGGGHAPDIMKLASYANILPSSTTPTIPYTVNTMDEHLDMMMVCHHLDAKVPEDVA FSHSRIRAATIAAEDILHDIGAISMTSSDSQAMGRVGEVIIRTWQVADKMKKQRGALA GENGNDNVRAKRYIAKYTINPAITHGLSHEVGSVEKGKLADLVLWDPVFFGVKPELVL KGGMIARAQMGDPNASIPTPEPVFMRQMYASYGKANRSTSITFMSQASIERGVAESLG LEKRISPVKNIRKLSKLDMKLNSALPKIEIDPKTYQVFADGEELSCQPVDYVPLGQRY FLF*" /label="ureC CDS" gene complement(3417828..3419537) /gene="ureC" /locus_tag="BSU_36640" /old_locus_tag="BSU36640" /label="ureC gene" CDS complement(3419534..3419908) /gene="ureB" /locus_tag="BSU_36650" /old_locus_tag="BSU36650" /EC_number="3.5.1.5" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9287005, 12401490, 16199586" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9287005, 12401490, 16199586; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="urease (beta subunit)" /protein_id="NP_391546.1" /db_xref="EnsemblGenomes-Gn:BSU36650" /db_xref="EnsemblGenomes-Tr:CAB15682" /db_xref="GOA:P71035" /db_xref="InterPro:IPR002019" /db_xref="InterPro:IPR036461" /db_xref="SubtiList:BG11982" /db_xref="UniProtKB/Swiss-Prot:P71035" /translation="MKPGAFQIAEGTITINEGREIREVTVKNTGSRSIQVGSHFHFAE ANGALLFDRELAIGMRLDVPSGTSVRFEPGEQKTVSLVEIRGRKTIRGLNGMADTFID ERGKEKTLANLKQAGWMEGVIR*" /label="ureB CDS" gene complement(3419534..3419908) /gene="ureB" /locus_tag="BSU_36650" /old_locus_tag="BSU36650" /label="ureB gene" CDS complement(3419905..3420222) /gene="ureA" /locus_tag="BSU_36660" /old_locus_tag="BSU36660" /EC_number="3.5.1.5" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9287005, 12401490, 16199586" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9287005, 12401490, 16199586; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="urease (gamma subunit)" /protein_id="NP_391547.1" /db_xref="EnsemblGenomes-Gn:BSU36660" /db_xref="EnsemblGenomes-Tr:CAB15683" /db_xref="GOA:P75030" /db_xref="InterPro:IPR002026" /db_xref="InterPro:IPR012010" /db_xref="InterPro:IPR036463" /db_xref="SubtiList:BG11981" /db_xref="UniProtKB/Swiss-Prot:P75030" /translation="MKLTPVEQEKLLIFAAGELAKQRKARGVLLNYPEAAAYITCFIM EGARDGKGVAELMEAGRHVLTEKDVMEGVPEMLDSIQVEATFPDGVKLVTVHQPISAE VKS*" /label="ureA CDS" gene complement(3419905..3420222) /gene="ureA" /locus_tag="BSU_36660" /old_locus_tag="BSU36660" /label="ureA gene" S_feature complement(3420223..3420307) /Source="Nicolas_S_feature" /locus_tag="new_3769109_3769193_c" /HighExp="BT, B60, B36, S1, Etha, LoTm, M9-stat, S2, T0.30H, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigH, SigB" /TUshortPSig="0.106, 1, 1" /TUlongSig="SigA, SigB" /TUlongPSig="0.993, 0.995" /label="S1413" upshifts complement(3420307) /Source="Nicolas_upshifts" /id="U2877" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.525474525474525" /psig="0.105894105894106" /xcortree=402 /SigmaFactorBS="gatgaagaaacggcatgccgctttgaaaggcatcttaccgta tgaCCCCCATTCTCGAAgaaagggaggtgatgtcccgcctgactgttccgcaaattcg t" /listShort="S1413, ureA, ureB, ureC, S1412, ywnA" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(3420309..3420322) /Source="Nicolas_upshift_promotors" /id="U2877" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.525474525474525" /psig="0.105894105894106" /xcortree=402 /SigmaFactorBS="gatgaagaaacggcatgccgctttgaaaggcatcttaccgta tgaCCCCCATTCTCGAAgaaagggaggtgatgtcccgcctgactgttccgcaaattcg t" /listShort="S1413, ureA, ureB, ureC, S1412, ywnA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature complement(3420309..3420402) /Source="Nicolas_S_feature" /locus_tag="new_3769195_3769288_c" /HighExp="BT, Etha, B60, S1, B36, BC, S2, LoTm, T3.0H, T3.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.30781199999999997" /TUshortSig="SigH, SigB" /TUshortPSig="1, 1" /TUlongSig="SigA, SigB" /TUlongPSig="0.993, 0.995" /label="S1414" CDS complement(3420403..3420567) /gene="ywzE" /locus_tag="BSU_36668" /old_locus_tag="BSU36668" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (putative phage interference protein)" /protein_id="YP_009514008.1" /translation="MVNLKNILLNKQLEGIQILIVELVRQVIIEISRKKDICYLSRAQ SGKRVNLIFP*" /label="ywzE CDS" gene complement(3420403..3420567) /gene="ywzE" /locus_tag="BSU_36668" /old_locus_tag="BSU36668" /label="ywzE gene" promotor_-10 complement(3420490..3420508) /Source="Nicolas_upshift_promotors" /id="U2878" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=403 /SigmaFactorBS="aaatctgaaaaatattttacttaataaacaattgGAAGGAAT TcagattttaatTGTCGAACTAGTCAGACAAgttattatagaaatttccagaaaaaaa g" /listShort="S1414, S1413, ureA, ureB, ureC" /listLong="S1412, ywnA" /label="promotor_-10" upshifts complement(3420502) /Source="Nicolas_upshifts" /id="U2878" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=403 /SigmaFactorBS="aaatctgaaaaatattttacttaataaacaattgGAAGGAAT TcagattttaatTGTCGAACTAGTCAGACAAgttattatagaaatttccagaaaaaaa g" /listShort="S1414, S1413, ureA, ureB, ureC" /listLong="S1412, ywnA" /label="upshifts" promotor_-35 complement(3420520..3420528) /Source="Nicolas_upshift_promotors" /id="U2878" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=403 /SigmaFactorBS="aaatctgaaaaatattttacttaataaacaattgGAAGGAAT TcagattttaatTGTCGAACTAGTCAGACAAgttattatagaaatttccagaaaaaaa g" /listShort="S1414, S1413, ureA, ureB, ureC" /listLong="S1412, ywnA" /label="promotor_-35" S_feature complement(3420568..3420739) /Source="Nicolas_S_feature" /locus_tag="new_3769454_3769625_c" /HighExp="Etha, BT, S1, GM-0.2, GM-0.1, Salt, GM 5, T-5.40H, MG 60, MG 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="0.993, 1" /TUlongSig="SigB" /TUlongPSig="0.995" /label="S1415" CDS complement(3420740..3420922) /gene="ywzF" /locus_tag="BSU_36669" /old_locus_tag="BSU36669" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /db_xref="PSEUDO:CAX52705.1" /translation="MKAGILHSLRGTVAISEVTVHDAELMAIVGFSVSWRSAPQTGLH AMLPVAEQNNGLPSGM*" /label="ywzF CDS" gene complement(3420740..3420922) /gene="ywzF" /locus_tag="BSU_36669" /old_locus_tag="BSU36669" /pseudo /label="ywzF gene" S_feature complement(3420923..3421069) /Source="Nicolas_S_feature" /locus_tag="new_3769809_3769955_c" /HighExp="Etha, BT, S1, Salt, GM-0.2, GM-0.1, M9-stat, GM 5, GM 45, UNK1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.15897800000000001" /TUshortSig="SigA, SigB" /TUshortPSig="0.993, 1" /TUlongSig="SigB" /TUlongPSig="0.995" /label="S1416" promotor_-10 complement(3421057..3421076) /Source="Nicolas_upshift_promotors" /id="U2879" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.722277722277722" /psig="0.993006993006993" /xcortree=2881 /SigmaFactorBS="tttggtcaaggtaactaaattttttaaatatTCTTTGAAtta ataggcctcttCTATATAATGATGACATAAGttgtaaacttttataacatcatttgaa g" /listShort="S1416, ywzF, S1415" /listLong="ywzE, S1414, S1413, ureA, ureB, ureC, S1412, ywnA" /label="promotor_-10" upshifts complement(3421069) /Source="Nicolas_upshifts" /id="U2879" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.722277722277722" /psig="0.993006993006993" /xcortree=2881 /SigmaFactorBS="tttggtcaaggtaactaaattttttaaatatTCTTTGAAtta ataggcctcttCTATATAATGATGACATAAGttgtaaacttttataacatcatttgaa g" /listShort="S1416, ywzF, S1415" /listLong="ywzE, S1414, S1413, ureA, ureB, ureC, S1412, ywnA" /label="upshifts" S_feature complement(3421071..3421185) /Source="Nicolas_S_feature" /locus_tag="new_3769957_3770070_c" /HighExp="Etha, Salt, M9-stat, S8, B60, B36, Sw, Gly, LoTm, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="SigB" /TUlongPSig="0.995" /label="S1417" promotor_-35 complement(3421091..3421098) /Source="Nicolas_upshift_promotors" /id="U2879" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.722277722277722" /psig="0.993006993006993" /xcortree=2881 /SigmaFactorBS="tttggtcaaggtaactaaattttttaaatatTCTTTGAAtta ataggcctcttCTATATAATGATGACATAAGttgtaaacttttataacatcatttgaa g" /listShort="S1416, ywzF, S1415" /listLong="ywzE, S1414, S1413, ureA, ureB, ureC, S1412, ywnA" /label="promotor_-35" Polymorphism join(3421172,3421174) /Source="geneious" /ID="SNP_BsDelta6_3770059_3770058" /Polymorphism_Type="Insertion (tandem repeat)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=0 /Amino_Acid_Change /CDS_Position /Change="(A)8 -> (A)9" /Codon_Change /Coverage=64 /locus_tag /Protein_Effect /Reference_Frequency /Reference_Nucleotides /Variant_Nucleotides="A" /Variant_P_Value="2.1e-197" /Variant_Raw_Frequency=61 /comment="-" /modified_by="User" / /label="Polymorphism_Delta6" upshifts 3421199 /Source="Nicolas_upshifts" /id="U2880" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.702297702297702" /psig="0.010989010989011" /xcortree=123 /SigmaFactorBS="tttttttgttatatttattcacatcagaaaaagcgaaaaaaa agacaagaaacatttcgtttcCTGCCtcttccgtacgattaatctttatctgaaaatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 3421202..3421206 /Source="Nicolas_upshift_promotors" /id="U2880" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.702297702297702" /psig="0.010989010989011" /xcortree=123 /SigmaFactorBS="tttttttgttatatttattcacatcagaaaaagcgaaaaaaa agacaagaaacatttcgtttcCTGCCtcttccgtacgattaatctttatctgaaaatt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(3421219..3421407) /gene="csbD" /locus_tag="BSU_36670" /old_locus_tag="BSU36670" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10376822, 11988534" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10376822, 11988534; Product type f: factor" /codon_start=1 /transl_table=11 /product="stress response protein" /protein_id="NP_391548.1" /db_xref="EnsemblGenomes-Gn:BSU36670" /db_xref="EnsemblGenomes-Tr:CAB15684" /db_xref="InterPro:IPR008462" /db_xref="InterPro:IPR036629" /db_xref="SubtiList:BG12478" /db_xref="UniProtKB/Swiss-Prot:P70964" /translation="MGNDSVKDKMKGGFNKAKGEVKDKVGDMADRTDMQAEGKKDKAK GEIQKDIGKAKDKFSDKD*" /label="csbD CDS" gene complement(3421219..3421407) /gene="csbD" /locus_tag="BSU_36670" /old_locus_tag="BSU36670" /label="csbD gene" downshifts complement(3421230) /Source="Nicolas_upshifts" /id="D1899" /incds=0 /nref=69 /ntot=139 /MaxReadThrough="6.39376" /MaxDrop="6.75256" /score="21.8463823" /energy="-10.2" /TU="U2881" /idTUdmin="U2882" /TUdmin=221 /isTUend="FALSE" /label="downshifts" downshifts 3421397 /Source="Nicolas_upshifts" /id="D1900" /incds=0 /nref=15 /ntot=36 /MaxReadThrough="0.59322" /MaxDrop="5.27268" /score="-5.47050177" /energy="-8.1" /TU="NA" /idTUdmin="U2880" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3421433..3421451) /Source="Nicolas_upshift_promotors" /id="U2881" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=222 /SigmaFactorBS="agagcgctacgaaatcgataaataacattagaaTGTTTATtg cctctcagatcGGGAAGTTAACAAGTACACacataattgagaggggagaattaacatg g" /listShort="csbD, S1417, S1416, ywzF, S1415, ywzE, S1414, S1413, ureA, ureB" /listLong="ureC, S1412, ywnA" /label="promotor_-10" upshifts complement(3421444) /Source="Nicolas_upshifts" /id="U2881" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=222 /SigmaFactorBS="agagcgctacgaaatcgataaataacattagaaTGTTTATtg cctctcagatcGGGAAGTTAACAAGTACACacataattgagaggggagaattaacatg g" /listShort="csbD, S1417, S1416, ywzF, S1415, ywzE, S1414, S1413, ureA, ureB" /listLong="ureC, S1412, ywnA" /label="upshifts" promotor_-35 complement(3421465..3421471) /Source="Nicolas_upshift_promotors" /id="U2881" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=222 /SigmaFactorBS="agagcgctacgaaatcgataaataacattagaaTGTTTATtg cctctcagatcGGGAAGTTAACAAGTACACacataattgagaggggagaattaacatg g" /listShort="csbD, S1417, S1416, ywzF, S1415, ywzE, S1414, S1413, ureA, ureB" /listLong="ureC, S1412, ywnA" /label="promotor_-35" CDS complement(3421480..3421980) /gene="ywmF" /locus_tag="BSU_36680" /old_locus_tag="BSU36680" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_391549.2" /db_xref="EnsemblGenomes-Gn:BSU36680" /db_xref="EnsemblGenomes-Tr:CAB15685" /db_xref="GOA:P70963" /db_xref="SubtiList:BG12477" /db_xref="UniProtKB/Swiss-Prot:P70963" /translation="MHVRGNSMFGFNDMVKFLWSFLIVLPLVQIIHVSGHSFMAFIFG GKGSLDIGMGKTLLKIGPIRFRTIYFIDSFCRYGELKIDNRFSNALVYAGGCLFNLIT IFAINLLIIHSVLKPNVFFYQFVYFSTYYVFFALLPVRYSEKKSSDGLAIYKVLRYGE RYEIDK*" /label="ywmF CDS" gene complement(3421480..3421980) /gene="ywmF" /locus_tag="BSU_36680" /old_locus_tag="BSU36680" /label="ywmF gene" promotor_-10 complement(3422016..3422035) /Source="Nicolas_upshift_promotors" /id="U2882" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=97 /SigmaFactorBS="tttatgcaaaaaaaggggagcatcggaaCGTTTATttccggg gagaacAGGAAAAATCGCTACAGCACtgttttttgaacaaaagccgttttgggatgca g" /listShort="ywmF" /listLong="csbD, S1417, S1416, ywzF, S1415, ywzE, S1414, S1413, ureA, ureB, ureC, S1412, ywnA" /label="promotor_-10" upshifts complement(3422023) /Source="Nicolas_upshifts" /id="U2882" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=97 /SigmaFactorBS="tttatgcaaaaaaaggggagcatcggaaCGTTTATttccggg gagaacAGGAAAAATCGCTACAGCACtgttttttgaacaaaagccgttttgggatgca g" /listShort="ywmF" /listLong="csbD, S1417, S1416, ywzF, S1415, ywzE, S1414, S1413, ureA, ureB, ureC, S1412, ywnA" /label="upshifts" promotor_-35 complement(3422049..3422055) /Source="Nicolas_upshift_promotors" /id="U2882" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=97 /SigmaFactorBS="tttatgcaaaaaaaggggagcatcggaaCGTTTATttccggg gagaacAGGAAAAATCGCTACAGCACtgttttttgaacaaaagccgttttgggatgca g" /listShort="ywmF" /listLong="csbD, S1417, S1416, ywzF, S1415, ywzE, S1414, S1413, ureA, ureB, ureC, S1412, ywnA" /label="promotor_-35" CDS complement(3422115..3423248) /gene="rapB" /locus_tag="BSU_36690" /old_locus_tag="BSU36690" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9843420, 10629174, 12875849, 19332814, 19684115" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9843420, 10629174, 12875849, 19332814, 19684115; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="response regulator aspartate phosphatase" /protein_id="NP_391550.1" /db_xref="EnsemblGenomes-Gn:BSU36690" /db_xref="EnsemblGenomes-Tr:CAB15686" /db_xref="GOA:P70962" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="SubtiList:BG11965" /db_xref="UniProtKB/Swiss-Prot:P70962" /translation="MAAYEIPSSQVGVKINKWYKHILAFQVADAVKLKEEIDLDIEQM EEDQLLLLYYQLISYRHQIMLDYVKPDLHEESQLQYRELIKTLESNQDSISGLSEYYF HLFRGMYEFEQNNYISAISFYRKAEKMLAFVEDEIERAEFHFKVAEVFYIMKQTHFSM NHAVQALETYKAHDFYRVRRIQCHFVISGNYIDYRNYEKALEHLDDAYRLALLEGQPR LIGSALYNIGNCYDDKGELDQAAEYFEKALPVFEDYQLEQLPKALFSLTRVLFKKQDS EAAIRYYEKGIAIAQKRNDFFSLAKYKFLQALYVESVNLNMIQEVFDYMEEKGLYVYI EEFALDAASYFSHREQYKEAVYFYEKAVSMREMIQRNDCLYEV*" /label="rapB CDS" gene complement(3422115..3423248) /gene="rapB" /locus_tag="BSU_36690" /old_locus_tag="BSU36690" /label="rapB gene" downshifts complement(3422133) /Source="Nicolas_upshifts" /id="D1901" /incds=0 /nref=244 /ntot=265 /MaxReadThrough="2.8683" /MaxDrop="6.81344" /score="30.5146793" /energy="-8.1" /TU="NA" /idTUdmin="U2883" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature complement(3423275..3423294) /Source="Nicolas_upshift_promotors" /id="U2883" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2953 /SigmaFactorBS="cataaagaaggaatcattgtaagaaaatttaattccaaagcc atacatTATGATAAAATATAACCAATtagaaaatagaaagggttggaggggcatggcc g" /listShort="rapB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3423282) /Source="Nicolas_upshifts" /id="U2883" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.994005994005994" /psig=1 /xcortree=2953 /SigmaFactorBS="cataaagaaggaatcattgtaagaaaatttaattccaaagcc atacatTATGATAAAATATAACCAATtagaaaatagaaagggttggaggggcatggcc g" /listShort="rapB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3423345..3423363) /Source="Nicolas_upshift_promotors" /id="U2884" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=2786 /SigmaFactorBS="tcggcactgtccggtaagcttttttattagaatccgaGTGCA AAAaatacgtagaaaaACCGAAATATATAAGGATAggcataaagaaggaatcattgta a" /listShort="rapB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3423361) /Source="Nicolas_upshifts" /id="U2884" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=2786 /SigmaFactorBS="tcggcactgtccggtaagcttttttattagaatccgaGTGCA AAAaatacgtagaaaaACCGAAATATATAAGGATAggcataaagaaggaatcattgta a" /listShort="rapB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3423377..3423384) /Source="Nicolas_upshift_promotors" /id="U2884" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.99100899100899" /psig="0.99100899100899" /xcortree=2786 /SigmaFactorBS="tcggcactgtccggtaagcttttttattagaatccgaGTGCA AAAaatacgtagaaaaACCGAAATATATAAGGATAggcataaagaaggaatcattgta a" /listShort="rapB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3423440..3424465) /gene="moaA" /locus_tag="BSU_36700" /old_locus_tag="BSU36700" /EC_number="4.1.99.22" /function="16.10: Respire" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 2170340, 7860592, 16632608, 19566093, 23286307, 25896388, 25941396, 26575208; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="GTP 3',8-cyclase" /protein_id="NP_391551.1" /db_xref="EnsemblGenomes-Gn:BSU36700" /db_xref="EnsemblGenomes-Tr:CAB15687" /db_xref="GOA:P39757" /db_xref="InterPro:IPR000385" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR010505" /db_xref="InterPro:IPR013483" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR034395" /db_xref="InterPro:IPR034481" /db_xref="SubtiList:BG10980" /db_xref="UniProtKB/Swiss-Prot:P39757" /translation="MITESRQMLDKRNRPLRDLRISVTDRCNFRCTYCMPAELFGPDY PFLKKEELLSFEELERLATLFVTRFGVEKIRLTGGEPLMRKDMPELIKKLARIPGIRD IAMTTNGSLLPVYAKRLKEAGLKRVTISLDSLEDERFKKINGRGVSVSKVLEGIEAAK QAGLGVKINMVVQKGVNEKDILPMARYFKEKGHILRFIEFMDVGNTNQWEKKDVMTKA EIIDLINKHMPVEPIAPNYIGEVASRFRYLDGSGEIGVISSVSDAFCGSCNRARLSAR GELFTCLFASSGFDLRAPVRQELSDDELSEMIGTVWKNRIDQYSVDRTLSKASGKKKV EMSYIGG*" /label="moaA CDS" gene complement(3423440..3424465) /gene="moaA" /locus_tag="BSU_36700" /old_locus_tag="BSU36700" /label="moaA gene" downshifts complement(3423453) /Source="Nicolas_upshifts" /id="D1902" /incds=0 /nref=23 /ntot=147 /MaxReadThrough="3.05546" /MaxDrop="3.66108" /score="13.625744" /energy="-10.8" /TU="NA" /idTUdmin="U2885" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3424481..3425269) /gene="fdhD" /locus_tag="BSU_36710" /old_locus_tag="BSU36710" /function="16.11: Scavenge (Catabolism)" /function="16.10: Respire" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2170340, 7860592, 19114526, 20011599, 22194618; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein sulfur transferase involved in molybdenum cofactor synthesis" /protein_id="NP_391552.1" /db_xref="EnsemblGenomes-Gn:BSU36710" /db_xref="EnsemblGenomes-Tr:CAB15688" /db_xref="GOA:P39756" /db_xref="InterPro:IPR003786" /db_xref="InterPro:IPR016193" /db_xref="SubtiList:BG10979" /db_xref="UniProtKB/Swiss-Prot:P39756" /translation="MNDKVTAVRDVWRYEQGEISKVEDRMVTEFPLTVILNGSEFVTL VCTPEHIEELVIGFLASEGVIRFQKEIKRFTIDESLGFVYVDLVHPETLDQKDYTKRV IGSCCGKGRHFYFQQDVKTAKTAVSQIKISPEACLALMKDMQQGSGTFQDTGGVHNAA LCDTEKLLLMRTDIGRHNALDKLYGHCLLNGMSVRDKLIVFSGRISSEVLLKAAKIGV SIVISKSAPTELAIQMAEELNITAIGFVRNGSFNVYTHPERIRE*" /label="fdhD CDS" gene complement(3424481..3425269) /gene="fdhD" /locus_tag="BSU_36710" /old_locus_tag="BSU36710" /label="fdhD gene" promotor_-10 complement(3425295..3425314) /Source="Nicolas_upshift_promotors" /id="U2885" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.965034965034965" /psig="0.986013986013986" /xcortree=1964 /SigmaFactorBS="tatagagggctctttttgtgtctcagAATTCGACaaaatccg aggagTGTGAAAAAATATAAAGGCAggaacattgcggaggggaagagacattgaacga t" /listShort="fdhD, moaA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3425301) /Source="Nicolas_upshifts" /id="U2885" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.965034965034965" /psig="0.986013986013986" /xcortree=1964 /SigmaFactorBS="tatagagggctctttttgtgtctcagAATTCGACaaaatccg aggagTGTGAAAAAATATAAAGGCAggaacattgcggaggggaagagacattgaacga t" /listShort="fdhD, moaA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3425303..3425514) /Source="Nicolas_S_feature" /locus_tag="new_3774188_3774399_c" /HighExp="Etha, Sw, Salt, Heat, S8, Gly, S6, S7, BC, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.16930300000000001" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1418" promotor_-35 complement(3425328..3425335) /Source="Nicolas_upshift_promotors" /id="U2885" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.965034965034965" /psig="0.986013986013986" /xcortree=1964 /SigmaFactorBS="tatagagggctctttttgtgtctcagAATTCGACaaaatccg aggagTGTGAAAAAATATAAAGGCAggaacattgcggaggggaagagacattgaacga t" /listShort="fdhD, moaA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3425515..3425676) /gene="ywmE" /locus_tag="BSU_36720" /old_locus_tag="BSU36720" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391553.1" /db_xref="EnsemblGenomes-Gn:BSU36720" /db_xref="EnsemblGenomes-Tr:CAB15689" /db_xref="GOA:P70966" /db_xref="SubtiList:BG12476" /db_xref="UniProtKB/Swiss-Prot:P70966" /translation="MKLFGMIFLIATVAFILLGVLLKLAAFFFVSILTLIAAIVLFTV LKKNQHNQT*" /label="ywmE CDS" gene complement(3425515..3425676) /gene="ywmE" /locus_tag="BSU_36720" /old_locus_tag="BSU36720" /label="ywmE gene" promotor_-10 complement(3425689..3425707) /Source="Nicolas_upshift_promotors" /id="U2886" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=166 /SigmaFactorBS="ggaacctaaagatcaggcgctcccccaggcgccttttttatt GGTTTAAaaacagtttgggcGGGAATGATACCCTAAAAAggggttgaacatatgaaat t" /listShort="ywmE, S1418" /listLong="fdhD, moaA" /label="promotor_-10" upshifts complement(3425709) /Source="Nicolas_upshifts" /id="U2886" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=166 /SigmaFactorBS="ggaacctaaagatcaggcgctcccccaggcgccttttttatt GGTTTAAaaacagtttgggcGGGAATGATACCCTAAAAAggggttgaacatatgaaat t" /listShort="ywmE, S1418" /listLong="fdhD, moaA" /label="upshifts" promotor_-35 complement(3425721..3425727) /Source="Nicolas_upshift_promotors" /id="U2886" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=166 /SigmaFactorBS="ggaacctaaagatcaggcgctcccccaggcgccttttttatt GGTTTAAaaacagtttgggcGGGAATGATACCCTAAAAAggggttgaacatatgaaat t" /listShort="ywmE, S1418" /listLong="fdhD, moaA" /label="promotor_-35" CDS complement(3425770..3426444) /gene="ywmD" /locus_tag="BSU_36730" /old_locus_tag="BSU36730" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_391554.1" /db_xref="EnsemblGenomes-Gn:BSU36730" /db_xref="EnsemblGenomes-Tr:CAB15690" /db_xref="InterPro:IPR002035" /db_xref="InterPro:IPR036465" /db_xref="SubtiList:BG12475" /db_xref="UniProtKB/Swiss-Prot:P70961" /translation="MKKLLAAGIIGLLTVSIASPSFAAEKQADTNVAVLFDGSGSMVQ KTGGERKIDIAKKSVKSFAELLPKDTNLMLRVFGHAGNNKLSGKALSCSTTETIYGLH PYEGSLFDNSLSELKPTGWTPIAKALADTRKEFEAFDADGKNVVYLITDGEETCGGDP AAEIEKLRASNVDTIVNIIGFNFDVKGNEEMKQAAVAGGGEYISANSADEFEQAWEKE AQKFTE*" /label="ywmD CDS" gene complement(3425770..3426444) /gene="ywmD" /locus_tag="BSU_36730" /old_locus_tag="BSU36730" /label="ywmD gene" downshifts complement(3425785) /Source="Nicolas_upshifts" /id="D1903" /incds=0 /nref=16 /ntot=88 /MaxReadThrough="0.76221" /MaxDrop="4.19611" /score="25.2461653" /energy="-9.6" /TU="NA" /idTUdmin="U2886" /TUdmin="-462" /isTUend="FALSE" /label="downshifts" CDS complement(3426497..3426637) /locus_tag="BSU_36739" /old_locus_tag="BSU36739" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514009.1" /translation="MITQAVYAFWAEMAKNERHFKRFWTDRESSTKGSMSYIFLHFRI LA*" /label="hypothetical protein CDS" gene complement(3426497..3426637) /locus_tag="BSU_36739" /old_locus_tag="BSU36739" /label="gene" CDS complement(3426768..3427451) /gene="ywmC" /locus_tag="BSU_36740" /old_locus_tag="BSU36740" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative exported protein" /protein_id="NP_391555.1" /db_xref="EnsemblGenomes-Gn:BSU36740" /db_xref="EnsemblGenomes-Tr:CAB15691" /db_xref="InterPro:IPR002035" /db_xref="InterPro:IPR036465" /db_xref="SubtiList:BG12474" /db_xref="UniProtKB/Swiss-Prot:P70960" /translation="MKKRFSLIMMTGLLFGLTSPAFAAEKTETEAKAPANVAVLLDAS GSMAKRIDGVSKFNSAKKEISKFASSLPEGTQVKMSVFGSEGNNKNSGKVQSCEAIRN VYGFQSFNEQSFLNSLNTIGPTGWTPIAKALNEAKSSFDQLDAKGEKVVYLLTDGEET CGGNPIKTAKELQKDNITVNVIGFDYKEGYKGQLNAIAKVGGGEYFPAYTQKDVEKIF TQQSLMLSK*" /label="ywmC CDS" gene complement(3426768..3427451) /gene="ywmC" /locus_tag="BSU_36740" /old_locus_tag="BSU36740" /label="ywmC gene" promotor_-35 3427828..3427832 /Source="Nicolas_upshift_promotors" /id="U2887" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.687312687312687" /psig="0.687312687312687" /xcortree=1394 /SigmaFactorBS="aacagaaaaagacgcccaatgagCGTCTttttctactttttc GCCATATATTTATTCAAAAAcgcatctgcctcagaaatttgtgtgccttggtaatagt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3427837..3428868) /gene="spoIID" /locus_tag="BSU_36750" /old_locus_tag="BSU36750" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15752199, 16959571, 17376078, 27226615" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15752199, 16959571, 17376078, 27226615; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="lytic transglycosylase; autolysin required for complete dissolution of the asymmetric septum (stage II sporulation)" /protein_id="NP_391556.1" /db_xref="EnsemblGenomes-Gn:BSU36750" /db_xref="EnsemblGenomes-Tr:CAB15692" /db_xref="GOA:P07372" /db_xref="InterPro:IPR013486" /db_xref="InterPro:IPR013693" /db_xref="InterPro:IPR014225" /db_xref="SubtiList:BG10766" /db_xref="UniProtKB/Swiss-Prot:P07372" /translation="MKQFAITLSVLCALILLVPTLLVIPFQHNKEAGASVESEKTAVS TKPASKGAETLKASPVSIPVYRTANQSVENIPLEEYVIGVVASEMPATFKPEALKAQA LAARTFIVRLMVSNSAVEAPKGSLVDDTQMFQVYKSKAELKKQWGTSYETKLKKITDA VASTQGKILTYNNQPIEASFFSTSNGYTENAEAYWTSAIPYLKSVKSPWDKKSPKYKA TKTFTAAEFQQKLGVKLDGSSAVGKITGETPGHQVATAVINGKTLKGRDIREKLGLNS ADFEWKRNGDTITVTTRGFGHGVGMSQYGANFMAKEGKTVDDIVKYYYQGTQISEADA FLNKYMAKK*" /label="spoIID CDS" gene complement(3427837..3428868) /gene="spoIID" /locus_tag="BSU_36750" /old_locus_tag="BSU36750" /label="spoIID gene" promotor_-10 3427847..3427866 /Source="Nicolas_upshift_promotors" /id="U2887" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.687312687312687" /psig="0.687312687312687" /xcortree=1394 /SigmaFactorBS="aacagaaaaagacgcccaatgagCGTCTttttctactttttc GCCATATATTTATTCAAAAAcgcatctgcctcagaaatttgtgtgccttggtaatagt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(3427853) /Source="Nicolas_upshifts" /id="D1904" /incds=0 /nref=56 /ntot=156 /MaxReadThrough="0.87893" /MaxDrop="6.31542" /score="12.1351765" /energy="-8.7" /TU="NA" /idTUdmin="U2888" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts 3427865 /Source="Nicolas_upshifts" /id="U2887" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.687312687312687" /psig="0.687312687312687" /xcortree=1394 /SigmaFactorBS="aacagaaaaagacgcccaatgagCGTCTttttctactttttc GCCATATATTTATTCAAAAAcgcatctgcctcagaaatttgtgtgccttggtaatagt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3428896..3428914) /Source="Nicolas_upshift_promotors" /id="U2888" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=978 /SigmaFactorBS="taaatgacaaataaagtttctgtccaaaacgagaGTCATAtt agcttgtccctgcCCATAGACTAGACTAGAGTcgaatcccgagcaggaggcagctgaa t" /listShort="spoIID" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3428909) /Source="Nicolas_upshifts" /id="U2888" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=978 /SigmaFactorBS="taaatgacaaataaagtttctgtccaaaacgagaGTCATAtt agcttgtccctgcCCATAGACTAGACTAGAGTcgaatcccgagcaggaggcagctgaa t" /listShort="spoIID" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3428911..3429028) /Source="Nicolas_S_feature" /locus_tag="new_3777796_3777913_c" /HighExp="S8, M40t90, M9-stat, B36, LBGtran, G180, H2O2, M0t90, BT, T1.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigI, SigWXY, SigA" /TUshortPSig="0.947, 0.999, 1, 0.973" /TUlongSig="SigL, SigA, SigA" /TUlongPSig="0.722, 0.998, 1" /label="S1419" promotor_-35 complement(3428930..3428935) /Source="Nicolas_upshift_promotors" /id="U2888" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=978 /SigmaFactorBS="taaatgacaaataaagtttctgtccaaaacgagaGTCATAtt agcttgtccctgcCCATAGACTAGACTAGAGTcgaatcccgagcaggaggcagctgaa t" /listShort="spoIID" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3428970..3428975 /Source="Nicolas_upshift_promotors" /id="U2889" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1072 /SigmaFactorBS="taatatgactctcgttttggacagaaactttatttgtcattt aCGTATTcttttttgctattttGCGCATAATGATGATAATAcacaaaaaataaaaaac c" /listShort="S1420, ywmA" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3428987..3431647 /Source="Nicolas_S_feature" /locus_tag="new_3777872_3780532" /HighExp="S8, S6, S7, S4, S3, C30, S5, T5.0H, T3.30H, BT" /AntisenseName="murAA" /AntisenseCor="5.8371061376981899E-2" /AntisenseRegPval="-0.5" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.971" /TUlongSig="NA" /TUlongPSig="NA" /label="S1420" upshifts 3428987 /Source="Nicolas_upshifts" /id="U2889" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1072 /SigmaFactorBS="taatatgactctcgttttggacagaaactttatttgtcattt aCGTATTcttttttgctattttGCGCATAATGATGATAATAcacaaaaaataaaaaac c" /listShort="S1420, ywmA" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3428991..3429009 /Source="Nicolas_upshift_promotors" /id="U2889" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=1072 /SigmaFactorBS="taatatgactctcgttttggacagaaactttatttgtcattt aCGTATTcttttttgctattttGCGCATAATGATGATAATAcacaaaaaataaaaaac c" /listShort="S1420, ywmA" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(3429064..3430374) /gene="murAA" /locus_tag="BSU_36760" /old_locus_tag="BSU36760" /EC_number="2.5.1.7" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12682299, 14763982, 17714441" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14763982, 17714441; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylglucosamine 1-carboxyvinyltransferase" /protein_id="NP_391557.1" /db_xref="EnsemblGenomes-Gn:BSU36760" /db_xref="EnsemblGenomes-Tr:CAB15693" /db_xref="GOA:P70965" /db_xref="InterPro:IPR001986" /db_xref="InterPro:IPR005750" /db_xref="InterPro:IPR013792" /db_xref="InterPro:IPR036968" /db_xref="SubtiList:BG11955" /db_xref="UniProtKB/Swiss-Prot:P70965" /translation="MEKIIVRGGQKLNGTVKVEGAKNAVLPVIAASLLASEEKSVICD VPTLSDVYTINEVLRHLGADVHFENNEVTVNASYALQTEAPFEYVRKMRASVLVMGPL LARTGHARVALPGGCAIGSRPIDQHLKGFEAMGAEIKVGNGFIEAEVKGRLQGAKIYL DFPSVGATENLIMAAALAEGTTTLENVAKEPEIVDLANYINGMGGKIRGAGTGTIKIE GVEKLHGVKHHIIPDRIEAGTFMVAAAITEGNVLVKGAVPEHLTSLIAKMEEMGVTIK DEGEGLRVIGPKELKPIDIKTMPHPGFPTDMQSQMMALLLRASGTSMITETVFENRFM HAEEFRRMNGDIKIEGRSVIINGPVQLQGAEVAATDLRAGAALILAGLVAEGHTRVTE LKHLDRGYVDFHQKLAALGADIERVNDESASEQENKEVVSDLNA*" /label="murAA CDS" gene complement(3429064..3430374) /gene="murAA" /locus_tag="BSU_36760" /old_locus_tag="BSU36760" /label="murAA gene" downshifts complement(3429073) /Source="Nicolas_upshifts" /id="D1905" /incds=0 /nref=171 /ntot=256 /MaxReadThrough="5.3301" /MaxDrop="5.5423" /score="31.3825723" /energy="-11.8" /TU="U2890,U2891,U2892,U2894" /idTUdmin="U2890" /TUdmin="-98" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3430398..3430417) /Source="Nicolas_upshift_promotors" /id="U2890" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.947052947052947" /psig="0.947052947052947" /xcortree=752 /SigmaFactorBS="aatgggcggaaaacataccgttacgGTTGGCACACcaatcgt tacgacTGAATATTAATATAGAGAATttagggacgcggaggggaataccttggaaaaa a" /listShort="murAA, S1419" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3430405) /Source="Nicolas_upshifts" /id="U2890" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.947052947052947" /psig="0.947052947052947" /xcortree=752 /SigmaFactorBS="aatgggcggaaaacataccgttacgGTTGGCACACcaatcgt tacgacTGAATATTAATATAGAGAATttagggacgcggaggggaataccttggaaaaa a" /listShort="murAA, S1419" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3430408..3431148) /gene="ywmB" /locus_tag="BSU_36770" /old_locus_tag="BSU36770" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391558.1" /db_xref="EnsemblGenomes-Gn:BSU36770" /db_xref="EnsemblGenomes-Tr:CAB15694" /db_xref="InterPro:IPR014794" /db_xref="InterPro:IPR036209" /db_xref="PDB:2FPN" /db_xref="SubtiList:BG12473" /db_xref="UniProtKB/Swiss-Prot:O32277" /translation="MKKKQVSHAIIISVMLSFVIAVFHTIHASELTPLAQMAEGMERQ DVSIDKWTLHAKQNLSLTEKEFYQKVQRLKQEYRQYDWVIAREDKMIKAIGTYTDKKN RTSFRLQLVTTLKKHNPTSYLLYEQMSLETPDSWNDTYEQFERETLGIFQEKVVIFTC LNGHLDDNMNIVLQKKANQLLNEFQARSVEHVVEPNFVSISAFTDEWEEYIMTSKHKM NLQIALRSAGMGGKHTVTVGTPIVTTEY*" /label="ywmB CDS" gene complement(3430408..3431148) /gene="ywmB" /locus_tag="BSU_36770" /old_locus_tag="BSU36770" /label="ywmB gene" promotor_-35 complement(3430431..3430440) /Source="Nicolas_upshift_promotors" /id="U2890" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.947052947052947" /psig="0.947052947052947" /xcortree=752 /SigmaFactorBS="aatgggcggaaaacataccgttacgGTTGGCACACcaatcgt tacgacTGAATATTAATATAGAGAATttagggacgcggaggggaataccttggaaaaa a" /listShort="murAA, S1419" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3430779) /Source="Nicolas_upshifts" /id="U2891" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1770 /SigmaFactorBS="acttcttttagactgcagcttgtcacaaCCCTCAAAAaacac aatccaacTTCGTATTTattatatgagcaaatgagtctagagacaccggatagctgga a" /listShort="murAA, S1419, spoIID" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3430781..3430789) /Source="Nicolas_upshift_promotors" /id="U2891" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1770 /SigmaFactorBS="acttcttttagactgcagcttgtcacaaCCCTCAAAAaacac aatccaacTTCGTATTTattatatgagcaaatgagtctagagacaccggatagctgga a" /listShort="murAA, S1419, spoIID" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3430803..3430811) /Source="Nicolas_upshift_promotors" /id="U2891" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1770 /SigmaFactorBS="acttcttttagactgcagcttgtcacaaCCCTCAAAAaacac aatccaacTTCGTATTTattatatgagcaaatgagtctagagacaccggatagctgga a" /listShort="murAA, S1419, spoIID" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3430903..3430918) /Source="Nicolas_upshift_promotors" /id="U2892" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2506 /SigmaFactorBS="tcactgaccgaaaaagaattttatcaaaaagTGCAACGTTTa aaacaagagtaTCGTCAATATGATTGGgtgattgcacgggaagataaaatgataaagg c" /listShort="murAA, S1419, spoIID" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3430911) /Source="Nicolas_upshifts" /id="U2892" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2506 /SigmaFactorBS="tcactgaccgaaaaagaattttatcaaaaagTGCAACGTTTa aaacaagagtaTCGTCAATATGATTGGgtgattgcacgggaagataaaatgataaagg c" /listShort="murAA, S1419, spoIID" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3430931..3430940) /Source="Nicolas_upshift_promotors" /id="U2892" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2506 /SigmaFactorBS="tcactgaccgaaaaagaattttatcaaaaagTGCAACGTTTa aaacaagagtaTCGTCAATATGATTGGgtgattgcacgggaagataaaatgataaagg c" /listShort="murAA, S1419, spoIID" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3431149..3431276) /Source="Nicolas_S_feature" /locus_tag="new_3780034_3780161_c" /HighExp="UNK1, S2, Lbexp, MG 60, MG 15, M9-tran, M/G, G135, MG 5, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.973" /TUlongSig="SigL, SigA, SigA" /TUlongPSig="0.722, 0.998, 1" /label="S1421" CDS complement(3431277..3431507) /gene="ywzB" /locus_tag="BSU_36780" /old_locus_tag="BSU36780" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391559.1" /db_xref="EnsemblGenomes-Gn:BSU36780" /db_xref="EnsemblGenomes-Tr:CAB15695" /db_xref="GOA:O32278" /db_xref="InterPro:IPR009526" /db_xref="SubtiList:BG14163" /db_xref="UniProtKB/Swiss-Prot:O32278" /translation="MSVLGQQAAIGIVVHLIFIAVTWWALQAVNIDPLIKKGKVVQAR LLMILLTIAIGTAVANFFLDYLNYSQQLPYLF*" /label="ywzB CDS" gene complement(3431277..3431507) /gene="ywzB" /locus_tag="BSU_36780" /old_locus_tag="BSU36780" /label="ywzB gene" S_feature complement(3431508..3431770) /Source="Nicolas_S_feature" /locus_tag="new_3780393_3780655_c" /HighExp="UNK1, S2, Lbexp, MG 5, M9-tran, M/G, MG 15, MG 60, GM 15, MG t5" /AntisenseName="ywmA" /AntisenseCor="-0.24099136307237601" /AntisenseRegPval="-4.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.973" /TUlongSig="SigL, SigA, SigA" /TUlongPSig="0.722, 0.998, 1" /label="S1422" misc_feature 3431643..3431662 /Source="Nicolas_upshift_promotors" /id="U2893" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.828171828171828" /psig=1 /xcortree=411 /SigmaFactorBS="cggaataatcagccaaatctagggctaatccccgcttaaagt gcgattcttttaCATGGTATACTTTATTGGAAaggagctggcaaatgtgaatcattct t" /listShort="ywmA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3431649 /Source="Nicolas_upshifts" /id="U2893" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.828171828171828" /psig=1 /xcortree=411 /SigmaFactorBS="cggaataatcagccaaatctagggctaatccccgcttaaagt gcgattcttttaCATGGTATACTTTATTGGAAaggagctggcaaatgtgaatcattct t" /listShort="ywmA" /GFF_Attribute="listLong" /label="upshifts" CDS 3431677..3432150 /gene="ywmA" /locus_tag="BSU_36790" /old_locus_tag="BSU36790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391560.1" /db_xref="EnsemblGenomes-Gn:BSU36790" /db_xref="EnsemblGenomes-Tr:CAB15696" /db_xref="SubtiList:BG12472" /db_xref="UniProtKB/Swiss-Prot:P70958" /translation="MNHSFFQPEKQYGEDLPIFDQEWEAIAFYYDYRQSQIEELNELC QFFNISLTYTRESLEELENLYFQSIQELLLADWNLPIEEFEKMISVYLIDCVIARHED AEWVVKPYPYKDGAYTLGFRRHRKSWHTMNACDGLYLRPKEDRPLLSLFDSLVRS*" /label="ywmA CDS" gene 3431677..3432150 /gene="ywmA" /locus_tag="BSU_36790" /old_locus_tag="BSU36790" /label="ywmA gene" promotor_-10 complement(3431754..3431773) /Source="Nicolas_upshift_promotors" /id="U2894" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.843156843156843" /psig="0.973026973026973" /xcortree=2712 /SigmaFactorBS="taagagaaatgttaaaaaactgacacaattcattcagttCTT CaatctgtgactgtcTATAATCATAATAGAATGCAattgcttcccattcctgatcaaa a" /listShort="S1422, ywzB, S1421, ywmB, murAA, S1419" /listLong="spoIID" /label="promotor_-10" upshifts complement(3431770) /Source="Nicolas_upshifts" /id="U2894" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.843156843156843" /psig="0.973026973026973" /xcortree=2712 /SigmaFactorBS="taagagaaatgttaaaaaactgacacaattcattcagttCTT CaatctgtgactgtcTATAATCATAATAGAATGCAattgcttcccattcctgatcaaa a" /listShort="S1422, ywzB, S1421, ywmB, murAA, S1419" /listLong="spoIID" /label="upshifts" S_feature complement(3431772..3432155) /Source="Nicolas_S_feature" /locus_tag="new_3780657_3781040_c" /HighExp="G135, G180, G150, H2O2, Oxctl, Paraq, Cold, M9-stat, C30, S0" /AntisenseName="ywmA" /AntisenseCor="-1.9581968147303098E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigL, SigA" /TUshortPSig="0.722, 0.998" /TUlongSig="SigA" /TUlongPSig=1 /label="S1423" promotor_-35 complement(3431788..3431791) /Source="Nicolas_upshift_promotors" /id="U2894" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.843156843156843" /psig="0.973026973026973" /xcortree=2712 /SigmaFactorBS="taagagaaatgttaaaaaactgacacaattcattcagttCTT CaatctgtgactgtcTATAATCATAATAGAATGCAattgcttcccattcctgatcaaa a" /listShort="S1422, ywzB, S1421, ywmB, murAA, S1419" /listLong="spoIID" /label="promotor_-35" CDS complement(3432184..3432582) /gene="atpC" /locus_tag="BSU_36800" /old_locus_tag="BSU36800" /EC_number="3.6.3.14" /function="16.7: Manage energy" /experiment="publication(s) with functional evidences, PMID:8021203, 12837747, 15347741, 22720735, 23967352" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8021203, 12837747, 15347741, 22720735, 23967352; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit epsilon, F1 subunit)" /protein_id="NP_391561.1" /db_xref="EnsemblGenomes-Gn:BSU36800" /db_xref="EnsemblGenomes-Tr:CAB15697" /db_xref="GOA:P37812" /db_xref="InterPro:IPR001469" /db_xref="InterPro:IPR020546" /db_xref="InterPro:IPR020547" /db_xref="InterPro:IPR036771" /db_xref="InterPro:IPR036794" /db_xref="SubtiList:BG10822" /db_xref="UniProtKB/Swiss-Prot:P37812" /translation="MKTVKVNIVTPDGPVYDADIEMVSVRAESGDLGILPGHIPTVAP LKIGAVRLKKDGQTEMVAVSGGFVEVRPDHVTILAQAAETAEGIDKERAEAARQRAQE RLNSQSDDTDIRRAELALQRALNRLDVAGK*" /label="atpC CDS" gene complement(3432184..3432582) /gene="atpC" /locus_tag="BSU_36800" /old_locus_tag="BSU36800" /label="atpC gene" downshifts complement(3432200) /Source="Nicolas_upshifts" /id="D1906" /incds=0 /nref=283 /ntot=320 /MaxReadThrough="4.15968" /MaxDrop="7.84101" /score="22.7623678" /energy="-10.8" /TU="U2897,U2899" /idTUdmin="U2895" /TUdmin=9 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3432574..3432592) /Source="Nicolas_upshift_promotors" /id="U2895" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=107 /SigmaFactorBS="ttgttgagaaagcaaaagaaatgggtgtagaAGTTTAAtctg gtcctaggaGGGTAAAAGCATGAAGACCgttaaagtcaatatcgttactcccgacggc c" /listShort="atpC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3432583) /Source="Nicolas_upshifts" /id="U2895" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=107 /SigmaFactorBS="ttgttgagaaagcaaaagaaatgggtgtagaAGTTTAAtctg gtcctaggaGGGTAAAAGCATGAAGACCgttaaagtcaatatcgttactcccgacggc c" /listShort="atpC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3432606..3432612) /Source="Nicolas_upshift_promotors" /id="U2895" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=107 /SigmaFactorBS="ttgttgagaaagcaaaagaaatgggtgtagaAGTTTAAtctg gtcctaggaGGGTAAAAGCATGAAGACCgttaaagtcaatatcgttactcccgacggc c" /listShort="atpC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3432606..3434027) /gene="atpD" /locus_tag="BSU_36810" /old_locus_tag="BSU36810" /EC_number="3.6.3.14" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:8021203, 15347741, 18174126, 22790590" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8021203, 15347741, 18174126, 22790590; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit beta, component F1)" /protein_id="NP_391562.1" /db_xref="EnsemblGenomes-Gn:BSU36810" /db_xref="EnsemblGenomes-Tr:CAB15698" /db_xref="GOA:P37809" /db_xref="InterPro:IPR000194" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004100" /db_xref="InterPro:IPR005722" /db_xref="InterPro:IPR020003" /db_xref="InterPro:IPR024034" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036121" /db_xref="SubtiList:BG10821" /db_xref="UniProtKB/Swiss-Prot:P37809" /translation="MKKGRVSQVLGPVVDVRFEDGHLPEIYNAIKISQPAASENEVGI DLTLEVALHLGDDTVRTIAMASTDGVQRGMEAVDTGAPISVPVGDVTLGRVFNVLGEN IDLNEPVPADAKKDPIHRQAPSFDQLSTEVEILETGIKVVDLLAPYIKGGKIGLFGGA GVGKTVLIQELINNIAQEHGGISVFAGVGERTREGNDLFYEMSDSGVINKTAMVFGQM NEPPGARMRVALTGLTMAEHFRDVQGQDVLFFIDNIFRFTQAGSEVSALLGRMPSAVG YQPTLATEMGQLQERITSTNVGSVTSIQAIYVPADDYTDPAPATTFAHLDATTNLERK LTEMGIYPAVDPLASTSRALAPEIVGEEHYAVAREVQSTLQRYKELQDIIAILGMDEL GEEDKLVVHRARRIQFFLSQNFHVAEQFTGQKGSYVPVKETVQGFKEILAGKYDHLPE DAFRLVGRIEEVVEKAKEMGVEV*" /label="atpD CDS" gene complement(3432606..3434027) /gene="atpD" /locus_tag="BSU_36810" /old_locus_tag="BSU36810" /label="atpD gene" CDS complement(3434053..3434916) /gene="atpG" /locus_tag="BSU_36820" /old_locus_tag="BSU36820" /EC_number="3.6.3.14" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:8021203, 15347741, 18174126, 22790590" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8021203, 15347741, 18174126, 22790590; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit gamma, component F1)" /protein_id="NP_391563.1" /db_xref="EnsemblGenomes-Gn:BSU36820" /db_xref="EnsemblGenomes-Tr:CAB15699" /db_xref="GOA:P37810" /db_xref="InterPro:IPR000131" /db_xref="InterPro:IPR023632" /db_xref="InterPro:IPR035968" /db_xref="SubtiList:BG10820" /db_xref="UniProtKB/Swiss-Prot:P37810" /translation="MASLRDIKSRITSTKKTSQITKAMQMVSAAKLNRAENNAKSFVP YMDKIQEVVSNVGRVSGNVKHPMLLSREVKKTAYLVITSDRGLAGAFNSSVLRSAYQA MQERHQSKDEYAVIAIGRVGRDFFKKREIPIISELTGLGDEVTFTEIKDLARQTIQMF IDGAFDELHLVYNHFVSAITQEVTEKKLLPLSDLGSGGGKRTASYEFEPSEEEVLEVL LPQYAESLIFGALLDSKASEHAARMTAMKNATDNAKELIDSLSLSYNRARQAAITQEI TEIVGGAAALE*" /label="atpG CDS" gene complement(3434053..3434916) /gene="atpG" /locus_tag="BSU_36820" /old_locus_tag="BSU36820" /label="atpG gene" S_feature complement(3434917..3434992) /Source="Nicolas_S_feature" /locus_tag="new_3783802_3783877_c" /HighExp="S0, S2, MG-0.2, MG-0.1, Mal, G150, BI, M0t45, G180, MG 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigL, SigA" /TUshortPSig="0.722, 0.998" /TUlongSig="SigA" /TUlongPSig=1 /label="S1424" CDS complement(3434993..3436501) /gene="atpA" /locus_tag="BSU_36830" /old_locus_tag="BSU36830" /EC_number="3.6.3.14" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:8021203, 15347741, 1655755" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8021203, 15347741, 1655755; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit alpha, component F1)" /protein_id="NP_391564.1" /db_xref="EnsemblGenomes-Gn:BSU36830" /db_xref="EnsemblGenomes-Tr:CAB15700" /db_xref="GOA:P37808" /db_xref="InterPro:IPR000194" /db_xref="InterPro:IPR000793" /db_xref="InterPro:IPR004100" /db_xref="InterPro:IPR005294" /db_xref="InterPro:IPR020003" /db_xref="InterPro:IPR023366" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR033732" /db_xref="InterPro:IPR036121" /db_xref="SubtiList:BG10819" /db_xref="UniProtKB/Swiss-Prot:P37808" /translation="MSIKAEEISTLIKQQIQNYQSDIEVQDVGTVIQVGDGIARVHGL DNCMAGELVEFSNGVLGMAQNLEESNVGIVILGPFSEIREGDEVKRTGRIMEVPVGEE LIGRIVNPLGQPVDGLGPILTSKTRPIESPAPGVMDRKSVHEPLQTGIKAIDALIPIG RGQRELIIGDRQTGKTSVAIDAILNQKDQDMICVYVAIGQKESTVRGVVETLRKHGAL DYTIVVTASASQPAPLLYLAPYAGVTMAEEFMYNGKHVLVVYDDLSKQAAAYRELSLL LRRPPGREAFPGDVFYLHSRLLERAAKLSDAKGAGSITALPFVETQAGDISAYIPTNV ISITDGQIFLQSDLFFSGVRPAINAGLSVSRVGGSAQIKAMKKVSGTLRLDLASYREL EAFAQFGSDLDQATQAKLNRGARTVEVLKQDLNKPLPVEKQVAILYALTKGYLDDIPV ADIRRFEEEYYMYLDQNHKDLLDGIAKTGNLPADEDFKAAIEGFKRTFAPSN*" /label="atpA CDS" gene complement(3434993..3436501) /gene="atpA" /locus_tag="BSU_36830" /old_locus_tag="BSU36830" /label="atpA gene" CDS complement(3436518..3437063) /gene="atpH" /locus_tag="BSU_36840" /old_locus_tag="BSU36840" /EC_number="3.6.3.14" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:8021203, 15347741, 1655755, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8021203, 15347741, 1655755, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit delta, component F1)" /protein_id="NP_391565.1" /db_xref="EnsemblGenomes-Gn:BSU36840" /db_xref="EnsemblGenomes-Tr:CAB15701" /db_xref="GOA:P37811" /db_xref="InterPro:IPR000711" /db_xref="InterPro:IPR020781" /db_xref="InterPro:IPR026015" /db_xref="SubtiList:BG10818" /db_xref="UniProtKB/Swiss-Prot:P37811" /translation="MSGSAVSKRYASALFDIANESAQLNQVEEELIVVKQVFQNEKAL NDVLNHPKVPAAKKKELIQNAFGSLSQSVLNTIFLLIDRHRAAIVPELTDEFIKLANV ARQTEDAIVYSVKPLTDAEMLPLSQVFAKKAGVASLRIRNEVQTDLIGGIKVRIGNRI YDGSVSGKLQRIERQLAGENR*" /label="atpH CDS" gene complement(3436518..3437063) /gene="atpH" /locus_tag="BSU_36840" /old_locus_tag="BSU36840" /label="atpH gene" CDS complement(3437060..3437572) /gene="atpF" /locus_tag="BSU_36850" /old_locus_tag="BSU36850" /EC_number="3.6.3.14" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1448623, 9069291, 15175330, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1448623, 9069291, 15175330, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit b, component F0)" /protein_id="NP_391566.1" /db_xref="EnsemblGenomes-Gn:BSU36850" /db_xref="EnsemblGenomes-Tr:CAB15702" /db_xref="GOA:P37814" /db_xref="InterPro:IPR002146" /db_xref="InterPro:IPR005864" /db_xref="InterPro:IPR028987" /db_xref="SubtiList:BG10817" /db_xref="UniProtKB/Swiss-Prot:P37814" /translation="MSQLPLELGLSFNGGDILFQLLAMLILLALLKKYALGPLLNIMK QREDHIAGEITSAEEKNKEAQQLIEEQRVLLKEARQESQTLIENAKKLGEKQKEEIIQ AARAESERLKEAARTEIVKEKEQAVSALREQVASLSVMIASKVIEKELDEQAQEKLIQ DYLKEVGESR*" /label="atpF CDS" gene complement(3437060..3437572) /gene="atpF" /locus_tag="BSU_36850" /old_locus_tag="BSU36850" /label="atpF gene" S_feature complement(3437573..3437734) /Source="Nicolas_S_feature" /locus_tag="new_3786458_3786619_c" /HighExp="S2, Lbstat, Mal, M40t90, M0t90, G150, MG-0.1, G135, M0t45, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigL, SigA" /TUshortPSig="0.722, 0.998" /TUlongSig="SigA" /TUlongPSig=1 /label="S1425" CDS complement(3437735..3437947) /gene="atpE" /locus_tag="BSU_36860" /old_locus_tag="BSU36860" /EC_number="3.6.3.14" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1448623, 9069291, 15175330" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1448623, 9069291, 15175330; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit c, component F0)" /protein_id="NP_391567.1" /db_xref="EnsemblGenomes-Gn:BSU36860" /db_xref="EnsemblGenomes-Tr:CAB15703" /db_xref="GOA:P37815" /db_xref="InterPro:IPR000454" /db_xref="InterPro:IPR002379" /db_xref="InterPro:IPR005953" /db_xref="InterPro:IPR020537" /db_xref="InterPro:IPR035921" /db_xref="SubtiList:BG10816" /db_xref="UniProtKB/Swiss-Prot:P37815" /translation="MNLIAAAIAIGLGALGAGIGNGLIVSRTVEGIARQPEAGKELRT LMFMGIALVEALPIIAVVIAFLAFFG*" /label="atpE CDS" gene complement(3437735..3437947) /gene="atpE" /locus_tag="BSU_36860" /old_locus_tag="BSU36860" /label="atpE gene" CDS complement(3437993..3438727) /gene="atpB" /locus_tag="BSU_36870" /old_locus_tag="BSU36870" /EC_number="3.6.3.14" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1448623, 9069291, 15175330, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1448623, 9069291, 15175330, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit a, component F0)" /protein_id="NP_391568.1" /db_xref="EnsemblGenomes-Gn:BSU36870" /db_xref="EnsemblGenomes-Tr:CAB15704" /db_xref="GOA:P37813" /db_xref="InterPro:IPR000568" /db_xref="InterPro:IPR023011" /db_xref="InterPro:IPR035908" /db_xref="SubtiList:BG10815" /db_xref="UniProtKB/Swiss-Prot:P37813" /translation="MNHGYRTIEFLGLTFNLTNILMITVASVIVLLIAILTTRTLSIR PGKAQNFMEWIVDFVRNIIGSTMDLKTGANFLALGVTLLMYIFVSNMLGLPFSITIGH ELWWKSPTADPAITLTLAVMVVALTHYYGVKMKGLKEYSKDYLRPVPFMLPMKIIEEF ANTLTLGLRLYGNIFAGEILLGLLAGLATSHYSQSVALGLVGTIGAILPMLAWQAFSL FIGAIQAFIFTMLTMVYMSHKISHDH*" /label="atpB CDS" gene complement(3437993..3438727) /gene="atpB" /locus_tag="BSU_36870" /old_locus_tag="BSU36870" /label="atpB gene" promotor_no_box 3438541..3438641 /Source="Nicolas_upshift_promotors" /id="U2896" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.974025974025974" /psig="0.002997002997003" /xcortree=76 /SigmaFactorBS="taatattgcggacgaaatcaacaatccattccataaagttct gggcttttccgggacggatcgaaagcgttcttgtcgtcaatatagcaatcaataaaac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 3438601 /Source="Nicolas_upshifts" /id="U2896" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.974025974025974" /psig="0.002997002997003" /xcortree=76 /SigmaFactorBS="taatattgcggacgaaatcaacaatccattccataaagttct gggcttttccgggacggatcgaaagcgttcttgtcgtcaatatagcaatcaataaaac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3438735..3439118) /gene="atpI" /locus_tag="BSU_36880" /old_locus_tag="BSU36880" /function="16.1: Circulate" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:12917488, 15849754, 16850406, 23123906" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12917488, 15849754, 16850406, 23123906; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ATP synthase (subunit i)" /protein_id="NP_391569.1" /db_xref="EnsemblGenomes-Gn:BSU36880" /db_xref="EnsemblGenomes-Tr:CAB15705" /db_xref="GOA:P37816" /db_xref="InterPro:IPR005598" /db_xref="SubtiList:BG10814" /db_xref="UniProtKB/Swiss-Prot:P37816" /translation="MDDPKLTFSRQRKYLLFILAVYVLGYGLTAYKTVFLGLILGTVF SLFNFLLLVRRMNAFDRAVEKGKSIRSLGSAARWCNAILAVAVAYKNPEYFHMASTVI GLMTIYPVIMIDSFIQLKRSSMEER*" /label="atpI CDS" gene complement(3438735..3439118) /gene="atpI" /locus_tag="BSU_36880" /old_locus_tag="BSU36880" /label="atpI gene" misc_feature complement(3438807..3438825) /Source="Nicolas_upshift_promotors" /id="U2897" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.722277722277722" /psig="0.722277722277722" /xcortree=2708 /SigmaFactorBS="gctgtggctgttgcctataaaaatcccgaatactttcatatg gcAAGTACAGTTATTGGATTAatgacaatataccctgtcattatgatagattccttta t" /listShort="atpB, atpE, S1425, atpF, atpH, atpA, S1424, atpG, atpD, atpC, S1423" /listLong="S1422, ywzB, S1421, ywmB, murAA, S1419, spoIID" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3438809) /Source="Nicolas_upshifts" /id="U2897" /multdbtbs="-" /comp="M18" /sig="SigL" /pcomp="0.722277722277722" /psig="0.722277722277722" /xcortree=2708 /SigmaFactorBS="gctgtggctgttgcctataaaaatcccgaatactttcatatg gcAAGTACAGTTATTGGATTAatgacaatataccctgtcattatgatagattccttta t" /listShort="atpB, atpE, S1425, atpF, atpH, atpA, S1424, atpG, atpD, atpC, S1423" /listLong="S1422, ywzB, S1421, ywmB, murAA, S1419, spoIID" /label="upshifts" S_feature complement(3439119..3439389) /Source="Nicolas_S_feature" /locus_tag="new_3788004_3788274_c" /HighExp="M9-stat, T1.30H, T0.30H, T1.0H, UNK1, B60, G135, G180, G150, T2.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.998, 0.999" /TUlongSig="SigA, SigA" /TUlongPSig="1, 0.96" /label="S1426" promotor_-35 3439351..3439360 /Source="Nicolas_upshift_promotors" /id="U2898" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.955044955044955" /psig="0.955044955044955" /xcortree=1223 /SigmaFactorBS="ttgctgagaggatttacattgaggatgaggactataatgaaa gctatgaaaACCTTCTCATaataccctcgtttAGCATACAATAGCCCCTAACatgtgt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3439360 /Source="Nicolas_upshifts" /id="U2898" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.955044955044955" /psig="0.955044955044955" /xcortree=1223 /SigmaFactorBS="ttgctgagaggatttacattgaggatgaggactataatgaaa gctatgaaaACCTTCTCATaataccctcgtttAGCATACAATAGCCCCTAACatgtgt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3439365..3439384) /Source="Nicolas_upshift_promotors" /id="U2899" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.577422577422577" /psig="0.998001998001998" /xcortree=2710 /SigmaFactorBS="attctgtggagacgtaaagtataaaaagttttttaactttaa acaGATTGACAcatgttaggggcTATTGTATGCTAAACGAGGGtattatgagaaggtt t" /listShort="S1426, atpI, atpB, atpE, S1425, atpF, atpH, atpA, S1424, atpG, atpD, atpC, S1423" /listLong="S1422, ywzB, S1421, ywmB, murAA, S1419, spoIID" /label="promotor_-10" promotor_-10 3439374..3439393 /Source="Nicolas_upshift_promotors" /id="U2898" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.955044955044955" /psig="0.955044955044955" /xcortree=1223 /SigmaFactorBS="ttgctgagaggatttacattgaggatgaggactataatgaaa gctatgaaaACCTTCTCATaataccctcgtttAGCATACAATAGCCCCTAACatgtgt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3439389) /Source="Nicolas_upshifts" /id="U2899" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.577422577422577" /psig="0.998001998001998" /xcortree=2710 /SigmaFactorBS="attctgtggagacgtaaagtataaaaagttttttaactttaa acaGATTGACAcatgttaggggcTATTGTATGCTAAACGAGGGtattatgagaaggtt t" /listShort="S1426, atpI, atpB, atpE, S1425, atpF, atpH, atpA, S1424, atpG, atpD, atpC, S1423" /listLong="S1422, ywzB, S1421, ywmB, murAA, S1419, spoIID" /label="upshifts" S_feature complement(3439391..3439512) /Source="Nicolas_S_feature" /locus_tag="new_3788276_3788397_c" /HighExp="Etha, G180, H2O2, G135, Oxctl, G150, LBGexp, dia15, B36, Paraq" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="SigA" /TUlongPSig="0.96" /label="S1427" promotor_-35 complement(3439397..3439404) /Source="Nicolas_upshift_promotors" /id="U2899" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.577422577422577" /psig="0.998001998001998" /xcortree=2710 /SigmaFactorBS="attctgtggagacgtaaagtataaaaagttttttaactttaa acaGATTGACAcatgttaggggcTATTGTATGCTAAACGAGGGtattatgagaaggtt t" /listShort="S1426, atpI, atpB, atpE, S1425, atpF, atpH, atpA, S1424, atpG, atpD, atpC, S1423" /listLong="S1422, ywzB, S1421, ywmB, murAA, S1419, spoIID" /label="promotor_-35" CDS complement(3439541..3440170) /gene="upp" /locus_tag="BSU_36890" /old_locus_tag="BSU36890" /EC_number="2.4.2.9" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7798145, 15689504, 15716449" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7798145, 15689504, 15716449; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="uracil phosphoribosyltransferase" /protein_id="NP_391570.1" /db_xref="EnsemblGenomes-Gn:BSU36890" /db_xref="EnsemblGenomes-Tr:CAB15706" /db_xref="GOA:P39149" /db_xref="InterPro:IPR000836" /db_xref="InterPro:IPR005765" /db_xref="InterPro:IPR029057" /db_xref="InterPro:IPR034332" /db_xref="SubtiList:BG10945" /db_xref="UniProtKB/Swiss-Prot:P39149" /translation="MGKVYVFDHPLIQHKLTYIRNENTGTKDFRELVDEVATLMAFEI TRDLPLEEVDINTPVQAAKSKVISGKKLGVVPILRAGLGMVDGILKLIPAAKVGHVGL YRDPETLKPVEYYVKLPSDVEEREFIVVDPMLATGGSAVEAIHSLKKRGAKNIRFMCL VAAPEGVEELQKHHSDVDIYIAALDEKLNEKGYIVPGLGDAGDRMFGTK*" /label="upp CDS" gene complement(3439541..3440170) /gene="upp" /locus_tag="BSU_36890" /old_locus_tag="BSU36890" /label="upp gene" downshifts complement(3439557) /Source="Nicolas_upshifts" /id="D1907" /incds=0 /nref=180 /ntot=252 /MaxReadThrough="5.83241" /MaxDrop="5.91252" /score="1.39547358" /energy="-7.3" /TU="U2900,U2901" /idTUdmin="U2900" /TUdmin="-154" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3440214..3440233) /Source="Nicolas_upshift_promotors" /id="U2900" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.682317682317682" /psig=1 /xcortree=2556 /SigmaFactorBS="aaacccgcttgggcttatgcccggcgggttttttgacgatgt TCTTGAAActcaatgtctttttTTGTAGAATCAATAGAAGTGtgtaattgttgatggg a" /listShort="upp, S1427" /listLong="S1426, atpI, atpB, atpE, S1425, atpF, atpH, atpA, S1424, atpG, atpD, atpC, S1423, S1422, ywzB, S1421, ywmB, murAA, S1419, spoIID" /label="promotor_-10" upshifts complement(3440237) /Source="Nicolas_upshifts" /id="U2900" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.682317682317682" /psig=1 /xcortree=2556 /SigmaFactorBS="aaacccgcttgggcttatgcccggcgggttttttgacgatgt TCTTGAAActcaatgtctttttTTGTAGAATCAATAGAAGTGtgtaattgttgatggg a" /listShort="upp, S1427" /listLong="S1426, atpI, atpB, atpE, S1425, atpF, atpH, atpA, S1424, atpG, atpD, atpC, S1423, S1422, ywzB, S1421, ywmB, murAA, S1419, spoIID" /label="upshifts" promotor_-35 complement(3440248..3440255) /Source="Nicolas_upshift_promotors" /id="U2900" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.682317682317682" /psig=1 /xcortree=2556 /SigmaFactorBS="aaacccgcttgggcttatgcccggcgggttttttgacgatgt TCTTGAAActcaatgtctttttTTGTAGAATCAATAGAAGTGtgtaattgttgatggg a" /listShort="upp, S1427" /listLong="S1426, atpI, atpB, atpE, S1425, atpF, atpH, atpA, S1424, atpG, atpD, atpC, S1423, S1422, ywzB, S1421, ywmB, murAA, S1419, spoIID" /label="promotor_-35" CDS complement(3440305..3441552) /gene="glyA" /locus_tag="BSU_36900" /old_locus_tag="BSU36900" /EC_number="2.1.2.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11390694, 11902725, 12682299, 12686103, 12923093, 15865438, 18483062" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11390694, 11902725, 12682299, 12686103, 12923093, 15865438, 18483062; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="serine hydroxymethyltransferase" /protein_id="NP_391571.1" /db_xref="EnsemblGenomes-Gn:BSU36900" /db_xref="EnsemblGenomes-Tr:CAB15707" /db_xref="GOA:P39148" /db_xref="InterPro:IPR001085" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR019798" /db_xref="SubtiList:BG10944" /db_xref="UniProtKB/Swiss-Prot:P39148" /translation="MKHLPAQDEQVFNAIKNERERQQTKIELIASENFVSEAVMEAQG SVLTNKYAEGYPGKRYYGGCEHVDVVEDIARDRAKEIFGAEHVNVQPHSGAQANMAVY FTILEQGDTVLGMNLSHGGHLTHGSPVNFSGVQYNFVEYGVDKETQYIDYDDVREKAL AHKPKLIVAGASAYPRTIDFKKFREIADEVGAYFMVDMAHIAGLVAAGLHPNPVPYAD FVTTTTHKTLRGPRGGMILCREEFGKKIDKSIFPGIQGGPLMHVIAAKAVSFGEVLQD DFKTYAQNVISNAKRLAEALTKEGIQLVSGGTDNHLILVDLRSLGLTGKVAEHVLDEI GITSNKNAIPYDPEKPFVTSGIRLGTAAVTSRGFDGDALEEVGAIIALALKNHEDEGK LEEARQRVAALTDKFPLYKELDY*" /label="glyA CDS" gene complement(3440305..3441552) /gene="glyA" /locus_tag="BSU_36900" /old_locus_tag="BSU36900" /label="glyA gene" downshifts complement(3440328) /Source="Nicolas_upshifts" /id="D1908" /incds=0 /nref=183 /ntot=229 /MaxReadThrough="5.99283" /MaxDrop="6.62881" /score="22.1245386" /energy="-15.8" /TU="U2901" /idTUdmin="U2902" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3441594..3441613) /Source="Nicolas_upshift_promotors" /id="U2901" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.495504495504495" /psig="0.999000999001" /xcortree=2312 /SigmaFactorBS="tttttaccaataaaaatttagattttttaaaaataatcTTTT ACatcggccttaaaaaCCATGTACAATAGTGATGGTaaaaacaaagaacaggatacgg a" /listShort="glyA, upp, S1427, S1426, atpI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3441611) /Source="Nicolas_upshifts" /id="U2901" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.495504495504495" /psig="0.999000999001" /xcortree=2312 /SigmaFactorBS="tttttaccaataaaaatttagattttttaaaaataatcTTTT ACatcggccttaaaaaCCATGTACAATAGTGATGGTaaaaacaaagaacaggatacgg a" /listShort="glyA, upp, S1427, S1426, atpI" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3441613..3441697) /Source="Nicolas_S_feature" /locus_tag="new_3790498_3790582_c" /HighExp="dia5, C90, dia15, Diami, Lbtran, LPhT, M40t45, H2O2, BI, Sw" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.96, 1" /TUlongSig="SigEF" /TUlongPSig="0.999" /label="S1428" promotor_-35 complement(3441628..3441633) /Source="Nicolas_upshift_promotors" /id="U2901" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.495504495504495" /psig="0.999000999001" /xcortree=2312 /SigmaFactorBS="tttttaccaataaaaatttagattttttaaaaataatcTTTT ACatcggccttaaaaaCCATGTACAATAGTGATGGTaaaaacaaagaacaggatacgg a" /listShort="glyA, upp, S1427, S1426, atpI" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3441742) /Source="Nicolas_upshifts" /id="D1909" /incds=0 /nref=3 /ntot=12 /MaxReadThrough="7.23859" /MaxDrop="5.0386" /score="-3.86767322" /energy="-4.3" /TU="U2902,U2903" /idTUdmin="U2904" /TUdmin=1137 /isTUend="FALSE" /label="downshifts" CDS complement(3441759..3442301) /gene="ywlG" /locus_tag="BSU_36910" /old_locus_tag="BSU36910" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15995210, 22333191" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391572.1" /db_xref="EnsemblGenomes-Gn:BSU36910" /db_xref="EnsemblGenomes-Tr:CAB15708" /db_xref="InterPro:IPR006340" /db_xref="InterPro:IPR028345" /db_xref="SubtiList:BG10943" /db_xref="UniProtKB/Swiss-Prot:P39157" /translation="MNELKQTWKTMLSEFQDQAELKQDQLFVLGCSTSEVAGSRIGTS GSVDIAESIYSGLAELREKTGIHLAFQCCEHLNRALVVEAETAKLFRLPTVSAVPVPK AGGAMASYAFKQMKSPVLVETIQADAGIDIGDTFIGMHLKPVAVPVRVSQNSLGSAHV TLARTRPKLIGGVRAVYECE*" /label="ywlG CDS" gene complement(3441759..3442301) /gene="ywlG" /locus_tag="BSU_36910" /old_locus_tag="BSU36910" /label="ywlG gene" CDS complement(3442314..3442763) /gene="rpiB" /locus_tag="BSU_36920" /old_locus_tag="BSU36920" /EC_number="5.3.1.6" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15755726, 15995210, 18640127, 19446032" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15755726, 15995210, 18640127, 19446032; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-ribose 5-phosphate epimerase (promiscuous)" /protein_id="NP_391573.1" /db_xref="EnsemblGenomes-Gn:BSU36920" /db_xref="EnsemblGenomes-Tr:CAB15709" /db_xref="GOA:P39156" /db_xref="InterPro:IPR003500" /db_xref="InterPro:IPR004785" /db_xref="InterPro:IPR036569" /db_xref="SubtiList:BG10942" /db_xref="UniProtKB/Swiss-Prot:P39156" /translation="MKVAIASDHGGVHIRNEIKELMDELQIEYIDMGCDCGSGSVDYP DYAFPVAEKVVSGEVDRGILICGTGIGMSISANKVKGIRCALAHDTFSAKATREHNDT NILAMGERVIGPGLAREIAKIWLTTEFTGGRHQTRIGKISDYEEKNL*" /label="rpiB CDS" gene complement(3442314..3442763) /gene="rpiB" /locus_tag="BSU_36920" /old_locus_tag="BSU36920" /label="rpiB gene" S_feature complement(3442764..3442863) /Source="Nicolas_S_feature" /locus_tag="new_3791649_3791748_c" /HighExp="Diami, dia5, C90, dia15, LPhT, M40t45, LBGtran, Lbtran, T-0.40H, H2O2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.68276199999999998" /TUshortSig="SigA, SigA" /TUshortPSig="0.96, 1" /TUlongSig="SigEF" /TUlongPSig="0.999" /label="S1429" promotor_-10 complement(3442855..3442874) /Source="Nicolas_upshift_promotors" /id="U2902" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.763236763236763" /psig="0.96003996003996" /xcortree=1986 /SigmaFactorBS="ataagttgtcagaaaatctgcaaacaggTCATTTGCaaatcc tgcgtgaAGGAGTAGAATATAGTGAAAagcacatcatatggtgtgaatcaaagagcgg a" /listShort="S1429, ywlF, ywlG, S1428, glyA" /listLong="upp, S1427, S1426, atpI" /label="promotor_-10" upshifts complement(3442863) /Source="Nicolas_upshifts" /id="U2902" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.763236763236763" /psig="0.96003996003996" /xcortree=1986 /SigmaFactorBS="ataagttgtcagaaaatctgcaaacaggTCATTTGCaaatcc tgcgtgaAGGAGTAGAATATAGTGAAAagcacatcatatggtgtgaatcaaagagcgg a" /listShort="S1429, ywlF, ywlG, S1428, glyA" /listLong="upp, S1427, S1426, atpI" /label="upshifts" promotor_-35 complement(3442888..3442895) /Source="Nicolas_upshift_promotors" /id="U2902" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.763236763236763" /psig="0.96003996003996" /xcortree=1986 /SigmaFactorBS="ataagttgtcagaaaatctgcaaacaggTCATTTGCaaatcc tgcgtgaAGGAGTAGAATATAGTGAAAagcacatcatatggtgtgaatcaaagagcgg a" /listShort="S1429, ywlF, ywlG, S1428, glyA" /listLong="upp, S1427, S1426, atpI" /label="promotor_-35" CDS complement(3442920..3443372) /gene="prpB" /locus_tag="BSU_36930" /old_locus_tag="BSU36930" /EC_number="3.9.1.2" /EC_number="3.1.3.48" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15995210, 22517742, 24825175, 25610436, 27524296" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15995210, 22517742, 24825175, 25610436, 27524296; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein-arginine(tyrosine moonlighting) phosphatase (oxidative stress)" /protein_id="NP_391574.1" /db_xref="EnsemblGenomes-Gn:BSU36930" /db_xref="EnsemblGenomes-Tr:CAB15710" /db_xref="GOA:P39155" /db_xref="InterPro:IPR017867" /db_xref="InterPro:IPR023485" /db_xref="InterPro:IPR036196" /db_xref="PDB:1ZGG" /db_xref="PDB:4ETI" /db_xref="PDB:4ETN" /db_xref="PDB:4KK3" /db_xref="PDB:4KK4" /db_xref="SubtiList:BG10941" /db_xref="UniProtKB/Swiss-Prot:P39155" /translation="MDIIFVCTGNTCRSPMAEALFKSIAEREGLNVNVRSAGVFASPN GKATPHAVEALFEKHIALNHVSSPLTEELMESADLVLAMTHQHKQIIASQFGRYRDKV FTLKEYVTGSHGDVLDPFGGSIDIYKQTRDELEELLRQLAKQLKKDRR*" /label="prpB CDS" gene complement(3442920..3443372) /gene="prpB" /locus_tag="BSU_36930" /old_locus_tag="BSU36930" /label="prpB gene" promotor_-10 complement(3443389..3443408) /Source="Nicolas_upshift_promotors" /id="U2903" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=1892 /SigmaFactorBS="agctgcttttgccaatttaatataccaataaaagaaacgaaG TCGccgtttcttttttcTTCATATATAATAGAGAAAAataaggggtgactgacatgga t" /listShort="ywlE, S1429, ywlF, ywlG, S1428, glyA" /listLong="upp" /label="promotor_-10" upshifts complement(3443407) /Source="Nicolas_upshifts" /id="U2903" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=1892 /SigmaFactorBS="agctgcttttgccaatttaatataccaataaaagaaacgaaG TCGccgtttcttttttcTTCATATATAATAGAGAAAAataaggggtgactgacatgga t" /listShort="ywlE, S1429, ywlF, ywlG, S1428, glyA" /listLong="upp" /label="upshifts" promotor_-35 complement(3443423..3443426) /Source="Nicolas_upshift_promotors" /id="U2903" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.983016983016983" /psig=1 /xcortree=1892 /SigmaFactorBS="agctgcttttgccaatttaatataccaataaaagaaacgaaG TCGccgtttcttttttcTTCATATATAATAGAGAAAAataaggggtgactgacatgga t" /listShort="ywlE, S1429, ywlF, ywlG, S1428, glyA" /listLong="upp" /label="promotor_-35" CDS complement(3443448..3444005) /gene="mntP" /locus_tag="BSU_36940" /old_locus_tag="BSU36940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16850406, 25774656, 25794618, 26076491; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="manganese efflux pump" /protein_id="NP_391575.1" /db_xref="EnsemblGenomes-Gn:BSU36940" /db_xref="EnsemblGenomes-Tr:CAB15711" /db_xref="GOA:P39154" /db_xref="InterPro:IPR003810" /db_xref="InterPro:IPR022929" /db_xref="SubtiList:BG10940" /db_xref="UniProtKB/Swiss-Prot:P39154" /translation="MSDLFIGELITLSIMAFALGMDAFSVGLGMGMVKLRKKQIFYIG FIIGLFHVIMPLAGMAAGNMLSGLLGVLAVYIGGALLFVLGVQMLMASFKQSEERFMS PAGPGLLLFAIGVSLDSFSVGLSLGIYGSHPLLTITLFGLFSMMLTWLGLLVGKQVQS WLGTYSEALGGIILIVFGLKLLLPI*" /label="mntP CDS" gene complement(3443448..3444005) /gene="mntP" /locus_tag="BSU_36940" /old_locus_tag="BSU36940" /label="mntP gene" promotor_-10 complement(3444032..3444050) /Source="Nicolas_upshift_promotors" /id="U2904" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=998 /SigmaFactorBS="cggaggaagagtgattcgctgaaagcagtcagatGTTCTAac cctttttggacacGCATAGGCTAAAAAAGCGGggcgtgtccaagggggttatttatgt a" /listShort="ywlD, ywlE" /listLong="S1429, ywlF, ywlG, S1428, glyA" /label="promotor_-10" upshifts complement(3444045) /Source="Nicolas_upshifts" /id="U2904" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=998 /SigmaFactorBS="cggaggaagagtgattcgctgaaagcagtcagatGTTCTAac cctttttggacacGCATAGGCTAAAAAAGCGGggcgtgtccaagggggttatttatgt a" /listShort="ywlD, ywlE" /listLong="S1429, ywlF, ywlG, S1428, glyA" /label="upshifts" promotor_-35 complement(3444066..3444071) /Source="Nicolas_upshift_promotors" /id="U2904" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=998 /SigmaFactorBS="cggaggaagagtgattcgctgaaagcagtcagatGTTCTAac cctttttggacacGCATAGGCTAAAAAAGCGGggcgtgtccaagggggttatttatgt a" /listShort="ywlD, ywlE" /listLong="S1429, ywlF, ywlG, S1428, glyA" /label="promotor_-35" CDS complement(3444084..3445124) /gene="tsaC" /locus_tag="BSU_36950" /old_locus_tag="BSU36950" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12682299, 16014871, 16890019, 17005971, 19884342, 20606270, 21775474, 19376873, 19578062, 20701780, 20824107, 21183954, 21285948, 22378793, 23072323, 27913733" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 16014871, 16890019, 17005971, 19884342, 20606270, 21775474, 19376873, 19578062, 20701780, 20824107, 21183954, 21285948, 22378793, 23072323, 27913733; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="tRNA(NNU) t(6)A37 threonylcarbamoyladenosine modification; threonine-dependent ADP-forming ATPase" /protein_id="NP_391576.1" /db_xref="EnsemblGenomes-Gn:BSU36950" /db_xref="EnsemblGenomes-Tr:CAB15712" /db_xref="GOA:P39153" /db_xref="InterPro:IPR005145" /db_xref="InterPro:IPR006070" /db_xref="InterPro:IPR010923" /db_xref="InterPro:IPR017945" /db_xref="SubtiList:BG10939" /db_xref="UniProtKB/Swiss-Prot:P39153" /translation="MKTKRWFVDVTDELSTNDPQIAQAAALLRENEVVAFPTETVYGL GANAKNTDAVKKIYEAKGRPSDNPLIVHIADISQLEDLTGPAPEKAKTLMKRFWPGAL TLILPCKPDALSPRVTAGLETVAIRMPDHPLALALIRESGLPIAAPSANLSGKPSPTK AEHVAHDLDGRIAGIVDGGPTGIGVESTVLSCADDIPVLLRPGGITKEQIEAVIGPIH VDKGLSDQNEKPISPGMKYTHYAPTAPLAICEGSPERIQHLIQEYQQGGRRVGVLTTE EKAGVYSADYVKSCGRRAQLETVAAGLYDALRSFDENKVDFIIAESFPDTGVGLAIMN RLMKAAGGRVIR*" /label="tsaC CDS" gene complement(3444084..3445124) /gene="tsaC" /locus_tag="BSU_36950" /old_locus_tag="BSU36950" /label="tsaC gene" downshifts complement(3444089) /Source="Nicolas_upshifts" /id="D1910" /incds=0 /nref=4 /ntot=166 /MaxReadThrough="2.08557" /MaxDrop="2.98653" /score="-6.24994287" /energy="-9.8" /TU="NA" /idTUdmin="U2905" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(3445125..3445189) /Source="Nicolas_S_feature" /locus_tag="new_3794010_3794074_c" /HighExp="dia15, Diami, C90, LBGstat, Heat, LBGtran, dia5, LBGexp, Lbexp, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="0.999, 0.444" /TUlongSig="NA" /TUlongPSig="NA" /label="S1430" promotor_-10 complement(3445179..3445198) /Source="Nicolas_upshift_promotors" /id="U2905" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.943056943056943" /psig="0.999000999001" /xcortree=2661 /SigmaFactorBS="ttattagcgttgtccacaatttgtggataacGCTTGttttat tacaggacaTCTTTTATACTTTCAAAAGGattacacgcgtaaaacaatcgttttattg t" /listShort="S1430, ywlC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3445189) /Source="Nicolas_upshifts" /id="U2905" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.943056943056943" /psig="0.999000999001" /xcortree=2661 /SigmaFactorBS="ttattagcgttgtccacaatttgtggataacGCTTGttttat tacaggacaTCTTTTATACTTTCAAAAGGattacacgcgtaaaacaatcgttttattg t" /listShort="S1430, ywlC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3445191..3445280) /Source="Nicolas_S_feature" /locus_tag="new_3794076_3794165_c" /HighExp="S3, M9-stat, Etha, LoTm, T5.0H, S7, S8, S4, BT, S5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.444" /TUlongSig="NA" /TUlongPSig="NA" /label="S1431" promotor_-35 complement(3445214..3445218) /Source="Nicolas_upshift_promotors" /id="U2905" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.943056943056943" /psig="0.999000999001" /xcortree=2661 /SigmaFactorBS="ttattagcgttgtccacaatttgtggataacGCTTGttttat tacaggacaTCTTTTATACTTTCAAAAGGattacacgcgtaaaacaatcgttttattg t" /listShort="S1430, ywlC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3445281..3445724) /gene="ywlB" /locus_tag="BSU_36960" /old_locus_tag="BSU36960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391577.1" /db_xref="EnsemblGenomes-Gn:BSU36960" /db_xref="EnsemblGenomes-Tr:CAB15713" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG10938" /db_xref="UniProtKB/Swiss-Prot:P39152" /translation="MFYQLRVAREKDGDVLEAFLKQAKTSYEGVKEGFTQFLMLEDSE KNIAGCLGIEKISCDQGLLRSLVISDKLHQGHIVTLFQSMEVLCEKHQIKTVYLVANQ HSSADFLTAMGFERAESVPEELFSSDHFCESRQTEGAVLMKKASG*" /label="ywlB CDS" gene complement(3445281..3445724) /gene="ywlB" /locus_tag="BSU_36960" /old_locus_tag="BSU36960" /label="ywlB gene" CDS complement(3445791..3446465) /gene="spoIIR" /locus_tag="BSU_36970" /old_locus_tag="BSU36970" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15044948, 16824103, 18378688, 20802044, 22111992" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15044948, 16824103, 18378688, 20802044, 22111992; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator signal of pro-sigma(E) spoIIGA endopeptidase (stage II sporulation)" /protein_id="NP_391578.1" /db_xref="EnsemblGenomes-Gn:BSU36970" /db_xref="EnsemblGenomes-Tr:CAB15714" /db_xref="GOA:P39151" /db_xref="InterPro:IPR014202" /db_xref="SubtiList:BG10937" /db_xref="UniProtKB/Swiss-Prot:P39151" /translation="MKKTVIICIYIFLLLSGALVGLAKEETAQKSENQPVVIPDQAIR LRILANSDSDQDQQLKRHIRDAVNKEITTWVKDITSIEEARRVIRSKLPEIKAIAKET MEKEGANQSISVDFDKISFPTKLYGNMVYPAGEYEAILITLGNGDGANWWCVLFPPLC FLDFSNGEAVKEQEDKEASKKQTEKVLEDVTAKAEKAKKEENEEKEDGTEVKFFLVEW ISDLFS*" /label="spoIIR CDS" gene complement(3445791..3446465) /gene="spoIIR" /locus_tag="BSU_36970" /old_locus_tag="BSU36970" /label="spoIIR gene" promotor_-10 complement(3446227..3446245) /Source="Nicolas_upshift_promotors" /id="U2906" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=243 /SigmaFactorBS="caattaaaacgtcatataagagacgcggTGAATAAagaaatc acaacttGGGTAAAGGATATTACTTCtattgaagaagcgcgtcgcgtgattcgttcaa a" /listShort="ywlB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3446234) /Source="Nicolas_upshifts" /id="U2906" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=243 /SigmaFactorBS="caattaaaacgtcatataagagacgcggTGAATAAagaaatc acaacttGGGTAAAGGATATTACTTCtattgaagaagcgcgtcgcgtgattcgttcaa a" /listShort="ywlB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3446260..3446266) /Source="Nicolas_upshift_promotors" /id="U2906" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.992007992007992" /psig="0.992007992007992" /xcortree=243 /SigmaFactorBS="caattaaaacgtcatataagagacgcggTGAATAAagaaatc acaacttGGGTAAAGGATATTACTTCtattgaagaagcgcgtcgcgtgattcgttcaa a" /listShort="ywlB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3446497..3446514) /Source="Nicolas_upshift_promotors" /id="U2907" /multdbtbs="SigF" /comp="M3" /sig="Sig-" /pcomp="0.443556443556444" /psig="0.443556443556444" /xcortree=964 /SigmaFactorBS="tgctagatttttttcaccctgcaCGTTTAtcccaggctctcc ttGTCCATAATAGGGCTAGAaacaaagcacggagaggaacggtggggaccgatgaaaa a" /listShort="spoIIR, ywlB, S1431, S1430, ywlC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3446498) /Source="Nicolas_upshifts" /id="U2907" /multdbtbs="SigF" /comp="M3" /sig="Sig-" /pcomp="0.443556443556444" /psig="0.443556443556444" /xcortree=964 /SigmaFactorBS="tgctagatttttttcaccctgcaCGTTTAtcccaggctctcc ttGTCCATAATAGGGCTAGAaacaaagcacggagaggaacggtggggaccgatgaaaa a" /listShort="spoIIR, ywlB, S1431, S1430, ywlC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3446530..3446535) /Source="Nicolas_upshift_promotors" /id="U2907" /multdbtbs="SigF" /comp="M3" /sig="Sig-" /pcomp="0.443556443556444" /psig="0.443556443556444" /xcortree=964 /SigmaFactorBS="tgctagatttttttcaccctgcaCGTTTAtcccaggctctcc ttGTCCATAATAGGGCTAGAaacaaagcacggagaggaacggtggggaccgatgaaaa a" /listShort="spoIIR, ywlB, S1431, S1430, ywlC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3446571 /Source="Nicolas_upshifts" /id="U2908" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2167 /SigmaFactorBS="ggacaaggagagcctgggataaacgtgcagggtgaaaaaaat ctagcaagctgttaatcttattTATGGTACGATAGTGTTTTAggaggtttaagatgaa a" /listShort="ywlA" /GFF_Attribute="listLong" /label="upshifts" misc_feature 3446575..3446594 /Source="Nicolas_upshift_promotors" /id="U2908" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2167 /SigmaFactorBS="ggacaaggagagcctgggataaacgtgcagggtgaaaaaaat ctagcaagctgttaatcttattTATGGTACGATAGTGTTTTAggaggtttaagatgaa a" /listShort="ywlA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 3446606..3446968 /gene="ywlA" /locus_tag="BSU_36980" /old_locus_tag="BSU36980" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391579.1" /db_xref="EnsemblGenomes-Gn:BSU36980" /db_xref="EnsemblGenomes-Tr:CAB15715" /db_xref="GOA:P39150" /db_xref="InterPro:IPR031374" /db_xref="SubtiList:BG10936" /db_xref="UniProtKB/Swiss-Prot:P39150" /translation="MKYNYTVLLSAFTMSVLYSVIYIHSFIIAALITMAFYFLFPYLI FALPLQIMMNKKPKRFSPLYLLYYLAAAFIANAIIFGMLQPSGQSLFQNTAFYLFAVL TALIYWIWDSVLLQKKEA*" /label="ywlA CDS" gene 3446606..3446968 /gene="ywlA" /locus_tag="BSU_36980" /old_locus_tag="BSU36980" /label="ywlA gene" downshifts complement(3446981) /Source="Nicolas_upshifts" /id="D1911" /incds=0 /nref=27 /ntot=242 /MaxReadThrough="2.64328" /MaxDrop="5.72616" /score="26.8558862" /energy="-11.3" /TU="U2910" /idTUdmin="U2909" /TUdmin=12 /isTUend="TRUE" /label="downshifts" CDS complement(3446985..3447272) /gene="ywkF" /locus_tag="BSU_36990" /old_locus_tag="BSU36990" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391580.1" /db_xref="EnsemblGenomes-Gn:BSU36990" /db_xref="EnsemblGenomes-Tr:CAB15716" /db_xref="GOA:P45874" /db_xref="InterPro:IPR035167" /db_xref="SubtiList:BG11317" /db_xref="UniProtKB/Swiss-Prot:P45874" /translation="MKKALTAGILLIAIESMIGTIFPQALSYEAIFGVASLVLVGLAI ITSGLAVSGSDQRANYHSETKEGRTSRMKMAAAFFVAAIPSILCYLLTILF*" /label="ywkF CDS" gene complement(3446985..3447272) /gene="ywkF" /locus_tag="BSU_36990" /old_locus_tag="BSU36990" /label="ywkF gene" S_feature complement(3447273..3447331) /Source="Nicolas_S_feature" /locus_tag="new_3796158_3796216_c" /HighExp="S6, S8, S7, BT, G135, G180, Paraq, H2O2, G150, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigK, SigA" /TUshortPSig="1, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1432" promotor_-10 complement(3447329..3447348) /Source="Nicolas_upshift_promotors" /id="U2909" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1326 /SigmaFactorBS="cggaagtggaagtgctgaaagatattaatggaaaaGACAGAA CCAtatgcgctctgaTTCATAAAAATAAATAAGCAgcttgctggcgagtgaatggatc a" /listShort="S1432, ywkF" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(3447332..3448198) /gene="prmC" /locus_tag="BSU_37000" /old_locus_tag="BSU37000" /EC_number="2.1.1.297" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 16014871, 16364916, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamine methylase of release factor 1 (and perhaps others) at a GGQ site" /protein_id="NP_391581.1" /db_xref="EnsemblGenomes-Gn:BSU37000" /db_xref="EnsemblGenomes-Tr:CAB15717" /db_xref="GOA:P45873" /db_xref="InterPro:IPR002052" /db_xref="InterPro:IPR004556" /db_xref="InterPro:IPR007848" /db_xref="InterPro:IPR019874" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11316" /db_xref="UniProtKB/Swiss-Prot:P45873" /translation="MKTIFEALKWASSYLTEAGREENAAELLLLYDTGMERSKLLASL QEPIGEDELYRFKRHVEMHKEGVPVQYIIGKEFFYGREFMVNDDVLIPRPETEEVVFH LLEKYRSVFSEDGKLEVVDVGTGSGAIAVTLALENQSFSVSAVDISKEALQVASANAE KLGANVRFYQGDLLEPFIKAGKKADIIVSNPPYISEEEMADLSEIVRFHEPLHALTDG GDGLKFYKRFMEDIPLVMKDKVFVVFEIGWKQGAAVKDLILKAFKGAEVEVLKDINGK DRTICALIHKNK*" /label="prmC CDS" gene complement(3447332..3448198) /gene="prmC" /locus_tag="BSU_37000" /old_locus_tag="BSU37000" /label="prmC gene" upshifts complement(3447345) /Source="Nicolas_upshifts" /id="U2909" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1326 /SigmaFactorBS="cggaagtggaagtgctgaaagatattaatggaaaaGACAGAA CCAtatgcgctctgaTTCATAAAAATAAATAAGCAgcttgctggcgagtgaatggatc a" /listShort="S1432, ywkF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3447361..3447370) /Source="Nicolas_upshift_promotors" /id="U2909" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1326 /SigmaFactorBS="cggaagtggaagtgctgaaagatattaatggaaaaGACAGAA CCAtatgcgctctgaTTCATAAAAATAAATAAGCAgcttgctggcgagtgaatggatc a" /listShort="S1432, ywkF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3448200..3449270) /gene="prfA" /locus_tag="BSU_37010" /old_locus_tag="BSU37010" /experiment="publication(s) with functional evidences, PMID:2186375, 1408743, 10446248, 12237459, 12682299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2186375, 1408743, 10446248, 12237459, 12682299; Product type f: factor" /codon_start=1 /transl_table=11 /product="peptide chain release factor 1" /protein_id="NP_391582.1" /db_xref="EnsemblGenomes-Gn:BSU37010" /db_xref="EnsemblGenomes-Tr:CAB15718" /db_xref="GOA:P45872" /db_xref="InterPro:IPR000352" /db_xref="InterPro:IPR004373" /db_xref="InterPro:IPR005139" /db_xref="SubtiList:BG11244" /db_xref="UniProtKB/Swiss-Prot:P45872" /translation="MLDRLKSIEERYEKLNELLSDPEVVNDPKKLREYSKEQSDIQET VDVYRQYRDASEQLADAKAMLEEKLDAEMRDMVKEEISELQKETETLSERLKVLLIPK DPNDDKNVIMEIRGAAGGEEAALFAGNLYRMYSRYAELQGWKTEVMEANVTGTGGYKE IIFMITGSGAYSKLKYENGAHRVQRVPETESGGRIHTSTATVACLPEAEEVEVDIHEK DIRVDTFASSGPGGQSVNTTMSAVRLTHLPTGVVVSCQDEKSQIKNKEKAMKVLRARI YDKFQQEAQAEYDQTRKSAVGSGDRSERIRTYNFPQNRVTDHRIGLTIQKLDQILEGK LDEVVEALIVEDQASKLQQSEG*" /label="prfA CDS" gene complement(3448200..3449270) /gene="prfA" /locus_tag="BSU_37010" /old_locus_tag="BSU37010" /label="prfA gene" downshifts complement(3448203) /Source="Nicolas_upshifts" /id="D1912" /incds=0 /nref=23 /ntot=212 /MaxReadThrough="5.17118" /MaxDrop="3.44681" /score="-9.55295942" /energy="-10.5" /TU="U2910" /idTUdmin="U2912" /TUdmin=1122 /isTUend="FALSE" /label="downshifts" downshifts 3449271 /Source="Nicolas_upshifts" /id="D1913" /incds=0 /nref=1 /ntot=68 /MaxReadThrough="1.13519" /MaxDrop="4.28706" /score="36.3991981" /energy="-10.4" /TU="NA" /idTUdmin="U2911" /TUdmin="-990" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3449298..3449317) /Source="Nicolas_upshift_promotors" /id="U2910" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig="0.998001998001998" /xcortree=2501 /SigmaFactorBS="attccagtatagcagagggagcttttccagctgggattgaaa tgcTTTTGACtggggttaatcacTATACTATAATGAGAATGTTacgcacaggaaaaca g" /listShort="prfA, prmC, S1432, ywkF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3449322) /Source="Nicolas_upshifts" /id="U2910" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig="0.998001998001998" /xcortree=2501 /SigmaFactorBS="attccagtatagcagagggagcttttccagctgggattgaaa tgcTTTTGACtggggttaatcacTATACTATAATGAGAATGTTacgcacaggaaaaca g" /listShort="prfA, prmC, S1432, ywkF" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3449324..3449435) /Source="Nicolas_S_feature" /locus_tag="new_3798209_3798320_c" /HighExp="S6, S8, S7, BT, S5, Etha, B36, C30, S4, GM 25" /AntisenseName="ywkD" /AntisenseCor="-0.43140174721346802" /AntisenseRegPval="-12.9" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.927" /TUlongSig="NA" /TUlongPSig="NA" /label="S1433" promotor_-35 complement(3449331..3449337) /Source="Nicolas_upshift_promotors" /id="U2910" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig="0.998001998001998" /xcortree=2501 /SigmaFactorBS="attccagtatagcagagggagcttttccagctgggattgaaa tgcTTTTGACtggggttaatcacTATACTATAATGAGAATGTTacgcacaggaaaaca g" /listShort="prfA, prmC, S1432, ywkF" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 3449367..3449386 /Source="Nicolas_upshift_promotors" /id="U2911" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.561438561438561" /psig="0.99100899100899" /xcortree=2343 /SigmaFactorBS="attaaccccagtcaaaagcatttcaatcccagctggaaaagc tcccTCTGCTATACTGGAATTCGAggagggatgatgttgctgaaatccatacatcata t" /listShort="ywkD, racA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3449381 /Source="Nicolas_upshifts" /id="U2911" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.561438561438561" /psig="0.99100899100899" /xcortree=2343 /SigmaFactorBS="attaaccccagtcaaaagcatttcaatcccagctggaaaagc tcccTCTGCTATACTGGAATTCGAggagggatgatgttgctgaaatccatacatcata t" /listShort="ywkD, racA" /GFF_Attribute="listLong" /label="upshifts" CDS 3449396..3449782 /gene="ywkD" /locus_tag="BSU_37020" /old_locus_tag="BSU37020" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative enzyme" /protein_id="NP_391583.1" /db_xref="EnsemblGenomes-Gn:BSU37020" /db_xref="EnsemblGenomes-Tr:CAB15719" /db_xref="GOA:P45871" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG11315" /db_xref="UniProtKB/Swiss-Prot:P45871" /translation="MLLKSIHHIAIICSDYEKSKAFYVHKLGFQVIQETYREERGSYK LDLSLNGSYVIELFSFPDPPERQTRPEAAGLRHLAFTVGSLDKAVQELHEKGIETEPI RTDPLTGKRFTFFFDPDQLPLELYEQ*" /label="ywkD CDS" gene 3449396..3449782 /gene="ywkD" /locus_tag="BSU_37020" /old_locus_tag="BSU37020" /label="ywkD gene" promotor_-10 complement(3449417..3449435) /Source="Nicolas_upshift_promotors" /id="U2912" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.927072927072927" /psig="0.927072927072927" /xcortree=1264 /SigmaFactorBS="cttgaatcacctgaaaaccaagcttatgtacgtagaaagCTT TCGACttttcgtaatctgAACATATGATTGCAATATGatgtatggatttcagcaacat c" /listShort="S1433" /listLong="prfA" /label="promotor_-10" upshifts complement(3449435) /Source="Nicolas_upshifts" /id="U2912" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.927072927072927" /psig="0.927072927072927" /xcortree=1264 /SigmaFactorBS="cttgaatcacctgaaaaccaagcttatgtacgtagaaagCTT TCGACttttcgtaatctgAACATATGATTGCAATATGatgtatggatttcagcaacat c" /listShort="S1433" /listLong="prfA" /label="upshifts" promotor_-35 complement(3449449..3449456) /Source="Nicolas_upshift_promotors" /id="U2912" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.927072927072927" /psig="0.927072927072927" /xcortree=1264 /SigmaFactorBS="cttgaatcacctgaaaaccaagcttatgtacgtagaaagCTT TCGACttttcgtaatctgAACATATGATTGCAATATGatgtatggatttcagcaacat c" /listShort="S1433" /listLong="prfA" /label="promotor_-35" promotor_-35 3449850..3449858 /Source="Nicolas_upshift_promotors" /id="U2913" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=449 /SigmaFactorBS="ccactttctttgccgaatcttttcttgttttgtctaacggGA AGGGAACcgcattctatGGTCGAATACCTAGCTTAAaaggaggtatgggatcatgaat a" /listShort="racA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3449869..3449887 /Source="Nicolas_upshift_promotors" /id="U2913" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=449 /SigmaFactorBS="ccactttctttgccgaatcttttcttgttttgtctaacggGA AGGGAACcgcattctatGGTCGAATACCTAGCTTAAaaggaggtatgggatcatgaat a" /listShort="racA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3449870 /Source="Nicolas_upshifts" /id="U2913" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=449 /SigmaFactorBS="ccactttctttgccgaatcttttcttgttttgtctaacggGA AGGGAACcgcattctatGGTCGAATACCTAGCTTAAaaggaggtatgggatcatgaat a" /listShort="racA" /GFF_Attribute="listLong" /label="upshifts" CDS 3449904..3450458 /gene="racA" /locus_tag="BSU_37030" /old_locus_tag="BSU37030" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15780934, 17139259, 19478798, 22720735, 27059541, 27085804" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15780934, 17139259, 19478798, 22720735, 27059541, 27085804; Product type f : factor" /codon_start=1 /transl_table=11 /product="chromosome-pole-anchoring protein RacA" /protein_id="NP_391584.1" /db_xref="EnsemblGenomes-Gn:BSU37030" /db_xref="EnsemblGenomes-Tr:CAB15720" /db_xref="GOA:P45870" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="InterPro:IPR023522" /db_xref="PDB:5I41" /db_xref="PDB:5I44" /db_xref="SubtiList:BG11314" /db_xref="UniProtKB/Swiss-Prot:P45870" /translation="MNTNMVASELGVSAKTVQRWVKQLNLPAERNELGHYSFTAEDVK VLKSVQKQISEGTAIQDIHLPKSAKKRTGFLVQKTSSDTERRIEQLEQKLDTLLQQRQ DESELMARMSELERQLKQKADEGVSYQLLQHRREIDDILADLQSLTSQMKEFTAHSIP ETAAASEKTKTRKKPLLSLFKFQT*" /label="racA CDS" gene 3449904..3450458 /gene="racA" /locus_tag="BSU_37030" /old_locus_tag="BSU37030" /label="racA gene" misc_feature 3450388..3450392 /Source="Nicolas_upshift_promotors" /id="U2914" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.747252747252747" /psig="0.015984015984016" /xcortree=450 /SigmaFactorBS="ctgcaatcactgacctcacaaatgaaagaattcaccgctcat tcgatccccgagaCTGCTgctgcttctgaaaaaaccaaaacaagaaaaaaaccgctgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3450393 /Source="Nicolas_upshifts" /id="U2914" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.747252747252747" /psig="0.015984015984016" /xcortree=450 /SigmaFactorBS="ctgcaatcactgacctcacaaatgaaagaattcaccgctcat tcgatccccgagaCTGCTgctgcttctgaaaaaaccaaaacaagaaaaaaaccgctgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 3450437 /Source="Nicolas_upshifts" /id="D1914" /incds=0 /nref=213 /ntot=274 /MaxReadThrough="0.82868" /MaxDrop="8.28021" /score="36.3991981" /energy="-10.4" /TU="U2913" /idTUdmin="U2914" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3450492..3451451) /gene="ywkB" /locus_tag="BSU_37040" /old_locus_tag="BSU37040" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12949160, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative metabolite transporter" /protein_id="NP_391585.1" /db_xref="EnsemblGenomes-Gn:BSU37040" /db_xref="EnsemblGenomes-Tr:CAB15721" /db_xref="GOA:P45869" /db_xref="InterPro:IPR004776" /db_xref="InterPro:IPR014024" /db_xref="SubtiList:BG11313" /db_xref="UniProtKB/Swiss-Prot:P45869" /translation="MSILDILILLAPIFFVIVLGWFAGHFGSYDAKSAKGVSTLVTKY ALPAHFIAGILTTSRSEFLSQVPLMISLIIGIVGFYIIILLVCRFIFKYDLTNSSVFS LNSAQPTFAFMGIPVLGSLFGANEVAIPIAVTGIVVNAILDPLAIIIATVGESSKKNE ESGDSFWKMTGKSILHGLCEPLAAAPLISMILVLVFNFTLPELGVKMLDQLGSTTSGV ALFAVGVTVGIRKIKLSMPAIGIALLKVAVQPALMFLIALAIGLPADQTTKAILLVAF PGSAVAAMIATRFEKQEEETATAFVVSAILSLISLPIIIALTA*" /label="ywkB CDS" gene complement(3450492..3451451) /gene="ywkB" /locus_tag="BSU_37040" /old_locus_tag="BSU37040" /label="ywkB gene" downshifts complement(3450514) /Source="Nicolas_upshifts" /id="D1915" /incds=0 /nref=36 /ntot=74 /MaxReadThrough="2.86006" /MaxDrop="4.78642" /score="20.048754" /energy="-10.4" /TU="U2916" /idTUdmin="U2917" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3451489..3451507) /Source="Nicolas_upshift_promotors" /id="U2915" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=735 /SigmaFactorBS="acctgaatacaaaaaagtcatcgcgaaataattagCGAGTAA atttttctgtccgaGGGAAAGCTTTTTGTAAAGctaaagtatacggacataggatttg g" /listShort="ywkB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3451503) /Source="Nicolas_upshifts" /id="U2915" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=735 /SigmaFactorBS="acctgaatacaaaaaagtcatcgcgaaataattagCGAGTAA atttttctgtccgaGGGAAAGCTTTTTGTAAAGctaaagtatacggacataggatttg g" /listShort="ywkB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3451522..3451528) /Source="Nicolas_upshift_promotors" /id="U2915" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.994005994005994" /psig="0.994005994005994" /xcortree=735 /SigmaFactorBS="acctgaatacaaaaaagtcatcgcgaaataattagCGAGTAA atttttctgtccgaGGGAAAGCTTTTTGTAAAGctaaagtatacggacataggatttg g" /listShort="ywkB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3451533..3453281) /gene="maeA" /locus_tag="BSU_37050" /old_locus_tag="BSU37050" /EC_number="1.1.1.38" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12949160, 16788182, 20933603, 22740702, 23136871, 24325460" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12949160, 16788182, 20933603, 22740702, 23136871, 24325460; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="NAD-dependent malic enzyme (conversion of malateinto pyruvate)" /protein_id="NP_391586.1" /db_xref="EnsemblGenomes-Gn:BSU37050" /db_xref="EnsemblGenomes-Tr:CAB15722" /db_xref="GOA:P45868" /db_xref="InterPro:IPR001891" /db_xref="InterPro:IPR012301" /db_xref="InterPro:IPR012302" /db_xref="InterPro:IPR015884" /db_xref="InterPro:IPR036291" /db_xref="InterPro:IPR037062" /db_xref="SubtiList:BG11312" /db_xref="UniProtKB/Swiss-Prot:P45868" /translation="MGYYLTWLTISRKKEICLNNIKKTKEGHLETTLRGKEVLSIPTL NKGVAFSLEERQELGLEGLLPPTVLSLDQQAQRAYEQFQAQPDRLRQNVYLSDLANRN EVLFYKLLKNHLREMLPVVYTPTVGEAIQEYSHEYRRPQGIYLSIDNIDGIEKAFENL HATAGDIDLIVATDSESILGIGDWGVGGINIAIGKLAVYTAAAGIDPSRVIPVVLDVG TNNEKLLNDPLYIGNKHERVQGERYEAFIDAYVKAALKFFPKALLHWEDLGNKNARNI MKKYNHEILTFNDDIQGTGAITLAGVLAAMKKTGASIKDQRVVIFGAGSAGIGIADQI RDTMVLAGLSEEEANKRFYTLDYRGLLTEDIEGILDFQKPYLRNADEVKDWKRDEKGQ IPFDEVVRQAKPTILIGTSGVSGAFTEEIVKEMASHVDRPVIMPMSNPTHLAEAVPED LFKWTDGKVLIATGSPFDNVEYNGVSYEIGQSNNAFAFPGLGLGSIVAEARIITPAMF AATADAIAEMVDLETPGAGLLPSIDKLQEVSIQVAIAVAEAAIKDGVANRQPEDVKQA VLDAMWTPEYKKVIAK*" /label="maeA CDS" gene complement(3451533..3453281) /gene="maeA" /locus_tag="BSU_37050" /old_locus_tag="BSU37050" /label="maeA gene" promotor_-10 complement(3452007..3452025) /Source="Nicolas_upshift_promotors" /id="U2916" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=177 /SigmaFactorBS="aaaccaacaatcttgattggtacttcaggGGTTTCAggtgca ttcacagaGGAAATTGTAAAAGAAATGgcatctcacgtagaccgtccggttatcatgc c" /listShort="ywkB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3452015) /Source="Nicolas_upshifts" /id="U2916" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=177 /SigmaFactorBS="aaaccaacaatcttgattggtacttcaggGGTTTCAggtgca ttcacagaGGAAATTGTAAAAGAAATGgcatctcacgtagaccgtccggttatcatgc c" /listShort="ywkB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3452040..3452046) /Source="Nicolas_upshift_promotors" /id="U2916" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=177 /SigmaFactorBS="aaaccaacaatcttgattggtacttcaggGGTTTCAggtgca ttcacagaGGAAATTGTAAAAGAAATGgcatctcacgtagaccgtccggttatcatgc c" /listShort="ywkB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3453282..3453372) /Source="Nicolas_S_feature" /locus_tag="new_3802167_3802257_c" /HighExp="GM 25, GM 15, GM 60, GM 90, GM 120, MG-0.2, MG 15, GM 45, MG-0.1, GM 10" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1434" promotor_-10 complement(3453356..3453375) /Source="Nicolas_upshift_promotors" /id="U2917" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.731268731268731" /psig="0.999000999001" /xcortree=1757 /SigmaFactorBS="aaataagtatattaaaaaattaagtaattttcttctCTTGAA TTttgattttgacagGCATACAATAGCTTACGTAAtgtaaatagttttgagacattgt t" /listShort="S1434, maeA, ywkB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3453372) /Source="Nicolas_upshifts" /id="U2917" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.731268731268731" /psig="0.999000999001" /xcortree=1757 /SigmaFactorBS="aaataagtatattaaaaaattaagtaattttcttctCTTGAA TTttgattttgacagGCATACAATAGCTTACGTAAtgtaaatagttttgagacattgt t" /listShort="S1434, maeA, ywkB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3453389..3453396) /Source="Nicolas_upshift_promotors" /id="U2917" /multdbtbs="SigA" /comp="M17" /sig="SigA" /pcomp="0.731268731268731" /psig="0.999000999001" /xcortree=1757 /SigmaFactorBS="aaataagtatattaaaaaattaagtaattttcttctCTTGAA TTttgattttgacagGCATACAATAGCTTACGTAAtgtaaatagttttgagacattgt t" /listShort="S1434, maeA, ywkB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3453515) /Source="Nicolas_upshifts" /id="D1916" /incds=0 /nref=11 /ntot=126 /MaxReadThrough="2.81368" /MaxDrop="3.39095" /score="20.3711149" /energy="-7.5" /TU="NA" /idTUdmin="U2918" /TUdmin="-10" /isTUend="TRUE" /label="downshifts" CDS complement(3453520..3454107) /gene="tdk" /locus_tag="BSU_37060" /old_locus_tag="BSU37060" /EC_number="2.7.1.21" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 2423635, 17132103; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thymidine kinase" /protein_id="NP_391587.1" /db_xref="EnsemblGenomes-Gn:BSU37060" /db_xref="EnsemblGenomes-Tr:CAB15723" /db_xref="GOA:Q03221" /db_xref="InterPro:IPR001267" /db_xref="InterPro:IPR020633" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10419" /db_xref="UniProtKB/Swiss-Prot:Q03221" /translation="MYIMKQSGWLELICGSMFSGKSEELIRRVKRATYAKQEVRVFKP VIDNRYSEAAVVSHNGTSMTSYAISSAADIWDHISESTDVVAVDEVQFFDQEIVEVLS SLADKGYRVIAAGLDMDFRGEPFGVVPNIMAIAESVTKLQAVCSVCGSPASRTQRLID GKPASYDDPVILVGAAESYEARCRHHHEVPGKSKK*" /label="tdk CDS" gene complement(3453520..3454107) /gene="tdk" /locus_tag="BSU_37060" /old_locus_tag="BSU37060" /label="tdk gene" CDS complement(3454196..3454396) /gene="rpmEA" /locus_tag="BSU_37070" /old_locus_tag="BSU37070" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 15049826, 16014871, 16547061, 17163968, 17310068, 19648245, 20208344, 27561249" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 15049826, 16014871, 16547061, 17163968, 17310068, 19648245, 20208344, 27561249; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L31" /protein_id="NP_391588.1" /db_xref="EnsemblGenomes-Gn:BSU37070" /db_xref="EnsemblGenomes-Tr:CAB15724" /db_xref="GOA:Q03223" /db_xref="InterPro:IPR002150" /db_xref="InterPro:IPR027491" /db_xref="InterPro:IPR034704" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10417" /db_xref="UniProtKB/Swiss-Prot:Q03223" /translation="MKAGIHPNFKKATVKCACGNEFETGSVKEEVRVEICSECHPFYT GRQKFASADGRVDRFNKKYGLK*" /label="rpmEA CDS" gene complement(3454196..3454396) /gene="rpmEA" /locus_tag="BSU_37070" /old_locus_tag="BSU37070" /label="rpmEA gene" downshifts complement(3454209) /Source="Nicolas_upshifts" /id="D1917" /incds=0 /nref=268 /ntot=279 /MaxReadThrough="5.35148" /MaxDrop="6.82076" /score="15.63162" /energy="-10.3" /TU="U2918,U2919" /idTUdmin="U2921" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(3454397..3454474) /Source="Nicolas_S_feature" /locus_tag="new_3803282_3803359_c" /HighExp="HPh, LPh, LPhT, GM 45, Paraq, MG 45, MG 60, aero, LBGexp, MG 10" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.999, 0.811, 1" /TUlongSig="SigH, SigA" /TUlongPSig="1, 0.997" /label="S1435" promotor_-10 complement(3454470..3454489) /Source="Nicolas_upshift_promotors" /id="U2918" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.49050949050949" /psig="0.999000999001" /xcortree=2639 /SigmaFactorBS="tatcatctgcaagaaggtaaattgTATTTGCAaaagaagtaa atcACTGATATAATTTTCTCATAtgcgtttcggacaatgctccgaaataataactctg t" /listShort="S1435, rpmEA, tdk" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3454474) /Source="Nicolas_upshifts" /id="U2918" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.49050949050949" /psig="0.999000999001" /xcortree=2639 /SigmaFactorBS="tatcatctgcaagaaggtaaattgTATTTGCAaaagaagtaa atcACTGATATAATTTTCTCATAtgcgtttcggacaatgctccgaaataataactctg t" /listShort="S1435, rpmEA, tdk" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3454503..3454510) /Source="Nicolas_upshift_promotors" /id="U2918" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.49050949050949" /psig="0.999000999001" /xcortree=2639 /SigmaFactorBS="tatcatctgcaagaaggtaaattgTATTTGCAaaagaagtaa atcACTGATATAATTTTCTCATAtgcgtttcggacaatgctccgaaataataactctg t" /listShort="S1435, rpmEA, tdk" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3454515..3455798) /gene="rho" /locus_tag="BSU_37080" /old_locus_tag="BSU37080" /function="16.2: Construct biomass (Anabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10027981, 16014871, 18852477, 28520932, 28723971" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10027981, 16014871, 18852477, 28520932, 28723971; Product type f: factor" /codon_start=1 /transl_table=11 /product="transcriptional terminator Rho" /protein_id="NP_391589.2" /db_xref="EnsemblGenomes-Gn:BSU37080" /db_xref="EnsemblGenomes-Tr:CAB15725" /db_xref="GOA:Q03222" /db_xref="InterPro:IPR000194" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR004665" /db_xref="InterPro:IPR011112" /db_xref="InterPro:IPR011113" /db_xref="InterPro:IPR011129" /db_xref="InterPro:IPR012340" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036269" /db_xref="SubtiList:BG10416" /db_xref="UniProtKB/Swiss-Prot:Q03222" /translation="MKDVSISSLENMKLKELYELARHYKISYYSKLTKKELIFAILKA NAEQEDLLFMEGVLEIIQSEGFGFLRPINYSPSSEDIYISASQIRRFDLRNGDKVSGK VRPPKENERYYGLLHVEAVNGDDPESAKERVHFPALTPLYPDRQMVLETKPNFLSTRI MDMMAPVGFGQRGLIVAPPKAGKTMLLKEIANSITANQPEAELIVLLIDERPEEVTDI ERSVAGDVVSSTFDEVPENHIKVAELVLERAMRLVEHKKDVIILMDSITRLARAYNLV IPPSGRTLSGGIDPAAFHRPKRFFGAARNIEEGGSLTILATALVDTGSRMDDVIYEEF KGTGNMELHLDRSLAERRIFPAIDIRRSGTRKEELLVPKEHLDRLWSIRKTMSDSPDF AEKFMRKMKKTKTNQEFFDILNQEWKQANLSSARR*" /label="rho CDS" gene complement(3454515..3455798) /gene="rho" /locus_tag="BSU_37080" /old_locus_tag="BSU37080" /label="rho gene" S_feature complement(3455799..3456101) /Source="Nicolas_S_feature" /locus_tag="new_3804684_3804986_c" /HighExp="H2O2, Cold, G135, HPh, G180, G150, LBGstat, Oxctl, Paraq, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.811, 1" /TUlongSig="SigH, SigA" /TUlongPSig="1, 0.997" /label="S1436" CDS complement(3455829..3455990) /locus_tag="BSU_37089" /old_locus_tag="BSU37089" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function; PubMedId : 20525796" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514010.1" /db_xref="EnsemblGenomes-Gn:BSU37089" /db_xref="EnsemblGenomes-Tr:CCQ48606" /db_xref="UniProtKB/TrEMBL:L8EA05" /translation="MFLSSLPSKLIKTILLTKAPIMGGSVTDRSSFMLKKECALADVV QKQQMTCSE*" /label="hypothetical protein CDS" gene complement(3455829..3455990) /locus_tag="BSU_37089" /old_locus_tag="BSU37089" /label="gene" promotor_-10 complement(3456081..3456100) /Source="Nicolas_upshift_promotors" /id="U2919" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.72027972027972" /psig="0.811188811188811" /xcortree=2485 /SigmaFactorBS="aaagcgtcaactctatcaattccgtgtcaaaaccttatttcA GTTGaataattttttgaaaTAAGGTAAAAATAAAGAGTGctgcgaattttactgcgta a" /listShort="S1436, rho, S1435, rpmEA, tdk" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3456101) /Source="Nicolas_upshifts" /id="U2919" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.72027972027972" /psig="0.811188811188811" /xcortree=2485 /SigmaFactorBS="aaagcgtcaactctatcaattccgtgtcaaaaccttatttcA GTTGaataattttttgaaaTAAGGTAAAAATAAAGAGTGctgcgaattttactgcgta a" /listShort="S1436, rho, S1435, rpmEA, tdk" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3456116..3456120) /Source="Nicolas_upshift_promotors" /id="U2919" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.72027972027972" /psig="0.811188811188811" /xcortree=2485 /SigmaFactorBS="aaagcgtcaactctatcaattccgtgtcaaaaccttatttcA GTTGaataattttttgaaaTAAGGTAAAAATAAAGAGTGctgcgaattttactgcgta a" /listShort="S1436, rho, S1435, rpmEA, tdk" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3456205..3457170) /gene="glpX" /locus_tag="BSU_37090" /old_locus_tag="BSU37090" /EC_number="3.1.3.11" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:19270101" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19270101; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fructose 1,6-bisphosphatase class II" /protein_id="NP_391590.1" /db_xref="EnsemblGenomes-Gn:BSU37090" /db_xref="EnsemblGenomes-Tr:CAB15726" /db_xref="GOA:Q03224" /db_xref="InterPro:IPR004464" /db_xref="SubtiList:BG10415" /db_xref="UniProtKB/Swiss-Prot:Q03224" /translation="MERSLSMELVRVTEAAALASARWMGRGKKDEADEAATSAMRDVF DTVPMKGTVVIGEGEMDEAPMLYIGEKLGNGYGPRVDVAVDPLEGTNILASGGWNALT VIAVADHGTLLNAPDMYMQKIAVGPEAVGCIDIEAPVIDNLKAVAKAKNKDVEDVVAT ILNRERHAKIISELREAGARIKLINDGDVAGAINTAFDHTGVDILFGSGGAPEGVLSA VALKALGGEIIGKLLPQSEEEITRCHKMGLDLSKVLRMEDLVKGDDAIFAATGVTDGE LLKGVQFKGSVGTTESLVIRAKSGTVRFVDGRHSLKKKPNLVIRP*" /label="glpX CDS" gene complement(3456205..3457170) /gene="glpX" /locus_tag="BSU_37090" /old_locus_tag="BSU37090" /label="glpX gene" downshifts complement(3456211) /Source="Nicolas_upshifts" /id="D1918" /incds=0 /nref=56 /ntot=196 /MaxReadThrough="5.42698" /MaxDrop="5.21817" /score="-2.15106481" /energy="-10.2" /TU="U2921,U2922" /idTUdmin="U2922" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" promotor_-35 3456787..3456796 /Source="Nicolas_upshift_promotors" /id="U2920" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1384 /SigmaFactorBS="aggtgcttcgatgtcaatgcagcccaccgcTTCCGGACCGac tgcgatttttTGCATATACATGTCAGGAGCattcagaagcgtgccatggtctgcgacc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3456809..3456828 /Source="Nicolas_upshift_promotors" /id="U2920" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1384 /SigmaFactorBS="aggtgcttcgatgtcaatgcagcccaccgcTTCCGGACCGac tgcgatttttTGCATATACATGTCAGGAGCattcagaagcgtgccatggtctgcgacc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3456817 /Source="Nicolas_upshifts" /id="U2920" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1384 /SigmaFactorBS="aggtgcttcgatgtcaatgcagcccaccgcTTCCGGACCGac tgcgatttttTGCATATACATGTCAGGAGCattcagaagcgtgccatggtctgcgacc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3457201..3458490) /gene="murAB" /locus_tag="BSU_37100" /old_locus_tag="BSU37100" /EC_number="2.5.1.7" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:14763982, 19270101" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14763982, 19270101; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-N-acetylglucosamine 1-carboxyvinyltransferase" /protein_id="NP_391591.2" /db_xref="EnsemblGenomes-Gn:BSU37100" /db_xref="EnsemblGenomes-Tr:CAB15727" /db_xref="GOA:P19670" /db_xref="InterPro:IPR001986" /db_xref="InterPro:IPR005750" /db_xref="InterPro:IPR013792" /db_xref="InterPro:IPR036968" /db_xref="SubtiList:BG10414" /db_xref="UniProtKB/Swiss-Prot:P19670" /translation="MEKLNIAGGDSLNGTVHISGAKNSAVALIPATILANSEVTIEGL PEISDIETLRDLLKEIGGNVHFENGEMVVDPTSMISMPLPNGKVKKLRASYYLMGAML GRFKQAVIGLPGGCHLGPRPIDQHIKGFEALGAEVTNEQGAIYLRAERLRGARIYLDV VSVGATINIMLAAVLAEGKTIIENAAKEPEIIDVATLLTSMGAKIKGAGTNVIRIDGV KELHGCKHTIIPDRIEAGTFMIAGAAMGKEVIIDNVIPTHLESLTAKLREMGYHIETS DDQLLIVGGQKNLKPVDVKTLVYPGFPTDLQQPMTALLTRAKGTSVVTDTIYSARFKH IDELRRMGANMKVEGRSAIITGPVELQGAKVKASDLRAGACLVVAGLMADGVTEITGL EHIDRGYSSLEKKLEGLGATIWRERMTDEEIEQLQNS*" /label="murAB CDS" gene complement(3457201..3458490) /gene="murAB" /locus_tag="BSU_37100" /old_locus_tag="BSU37100" /label="murAB gene" S_feature complement(3458491..3458850) /Source="Nicolas_S_feature" /locus_tag="new_3807376_3807735_c" /HighExp="dia5, Fru, UNK1, Glucon, HiOs, T-5.40H, nit, SMM, MG 120, Mal" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.16076699999999999" /TUshortSig="SigA, SigH" /TUshortPSig="1, 1" /TUlongSig="SigA" /TUlongPSig="0.997" /label="S1437" CDS complement(3458869..3459507) /gene="tal" /locus_tag="BSU_37110" /old_locus_tag="BSU37110" /EC_number="2.2.1.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:4275311, 12469342, 22212631, 23468065" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4275311, 12469342, 22212631, 23468065; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="transaldolase" /protein_id="NP_391592.3" /db_xref="EnsemblGenomes-Gn:BSU37110" /db_xref="EnsemblGenomes-Tr:CAB15728" /db_xref="GOA:P19669" /db_xref="InterPro:IPR001585" /db_xref="InterPro:IPR004731" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR018225" /db_xref="InterPro:IPR022999" /db_xref="InterPro:IPR033919" /db_xref="PDB:3R8R" /db_xref="SubtiList:BG10413" /db_xref="UniProtKB/Swiss-Prot:P19669" /translation="MLFFVDTANIDEIREANELGILAGVTTNPSLVAKEANVSFHDRL REITDVVKGSVSAEVISLKAEEMIEEGKELAKIAPNITVKIPMTSDGLKAVRALTDLG IKTNVTLIFNANQALLAARAGATYVSPFLGRLDDIGHNGLDLISEVKQIFDIHGLDTQ IIAASIRHPQHVTEAALRGAHIGTMPLKVIHALTKHPLTDKGIEQFLADWNK*" /label="tal CDS" gene complement(3458869..3459507) /gene="tal" /locus_tag="BSU_37110" /old_locus_tag="BSU37110" /label="tal gene" downshifts complement(3458895) /Source="Nicolas_upshifts" /id="D1919" /incds=0 /nref=6 /ntot=65 /MaxReadThrough="6.97243" /MaxDrop="4.038" /score="-6.93331064" /energy="-18.4" /TU="U2921,U2922" /idTUdmin="U2926" /TUdmin=1716 /isTUend="FALSE" /label="downshifts" S_feature complement(3459508..3459626) /Source="Nicolas_S_feature" /locus_tag="new_3808393_3808511_c" /HighExp="dia5, LBGtran, M40t45, Lbtran, Mt0, M40t90, M0t45, Lbstat, Lbexp, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH" /TUshortPSig="1, 1" /TUlongSig="SigA" /TUlongPSig="0.997" /label="S1438" CDS complement(3459627..3460484) /gene="fbaA" /locus_tag="BSU_37120" /old_locus_tag="BSU37120" /EC_number="4.1.2.13" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10559165, 10658656, 12682299, 14526031, 17420574, 18310071, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10559165, 10658656, 12682299, 14526031, 17420574, 18310071, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fructose-1,6-bisphosphate aldolase" /protein_id="NP_391593.1" /db_xref="EnsemblGenomes-Gn:BSU37120" /db_xref="EnsemblGenomes-Tr:CAB15729" /db_xref="GOA:P13243" /db_xref="InterPro:IPR000771" /db_xref="InterPro:IPR011289" /db_xref="InterPro:IPR013785" /db_xref="SubtiList:BG10412" /db_xref="UniProtKB/Swiss-Prot:P13243" /translation="MPLVSMTEMLNTAKEKGYAVGQFNLNNLEFTQAILQAAEEEKSP VILGVSEGAGRYMGGFKTVVAMVKALMEEYKVTVPVAIHLDHGSSFESCAKAIHAGFT SVMIDASHHPFEENVATTAKVVELAHFHGVSVEAELGTVGGQEDDVIAEGVIYADPKE CQELVERTGIDCLAPALGSVHGPYKGEPNLGFKEMEEIGKSTGLPLVLHGGTGIPTAD IKKSISLGTAKINVNTENQISSAKAVRETLAAKPDEYDPRKYLGPAREAIKETVIGKM REFGSSNQA*" /label="fbaA CDS" gene complement(3459627..3460484) /gene="fbaA" /locus_tag="BSU_37120" /old_locus_tag="BSU37120" /label="fbaA gene" S_feature complement(3460485..3460611) /Source="Nicolas_S_feature" /locus_tag="new_3809370_3809496_c" /HighExp="C90, Lbtran, LBGtran, dia5, LBGexp, aero, M0t90, Glu, Lbexp, MG 5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigH" /TUshortPSig="1, 1" /TUlongSig="SigA" /TUlongPSig="0.997" /label="S1439" promotor_-10 complement(3460593..3460612) /Source="Nicolas_upshift_promotors" /id="U2921" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.807192807192807" /psig=1 /xcortree=2356 /SigmaFactorBS="taactgacaaaaagaagaaacaaatgaatcatgtcattATGT TGCCgatttgtcgaaaaGTTGGTATCCTAGTTATGGAgaaaaagcgatctgagtattt a" /listShort="S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI, S1436, rho, S1435, rpmEA" /listLong="tdk" /label="promotor_-10" upshifts complement(3460611) /Source="Nicolas_upshifts" /id="U2921" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.807192807192807" /psig=1 /xcortree=2356 /SigmaFactorBS="taactgacaaaaagaagaaacaaatgaatcatgtcattATGT TGCCgatttgtcgaaaaGTTGGTATCCTAGTTATGGAgaaaaagcgatctgagtattt a" /listShort="S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI, S1436, rho, S1435, rpmEA" /listLong="tdk" /label="upshifts" promotor_-35 complement(3460626..3460633) /Source="Nicolas_upshift_promotors" /id="U2921" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.807192807192807" /psig=1 /xcortree=2356 /SigmaFactorBS="taactgacaaaaagaagaaacaaatgaatcatgtcattATGT TGCCgatttgtcgaaaaGTTGGTATCCTAGTTATGGAgaaaaagcgatctgagtattt a" /listShort="S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI, S1436, rho, S1435, rpmEA" /listLong="tdk" /label="promotor_-35" CDS complement(3460665..3461039) /gene="spo0F" /locus_tag="BSU_37130" /old_locus_tag="BSU37130" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8257105, 11934609, 16788205, 17350627, 19004019, 19040634, 20413551, 22267516, 25256619, 26055117, 27543719" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8257105, 11934609, 16788205, 17350627, 19004019, 19040634, 20413551, 22267516, 25256619, 26055117, 27543719; Product type r : regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator of sporulation initiation" /protein_id="NP_391594.1" /db_xref="EnsemblGenomes-Gn:BSU37130" /db_xref="EnsemblGenomes-Tr:CAB15730" /db_xref="GOA:P06628" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="PDB:1F51" /db_xref="PDB:1FSP" /db_xref="PDB:1NAT" /db_xref="PDB:1PEY" /db_xref="PDB:1PUX" /db_xref="PDB:1SRR" /db_xref="PDB:2FSP" /db_xref="PDB:2FTK" /db_xref="PDB:2JVI" /db_xref="PDB:2JVJ" /db_xref="PDB:2JVK" /db_xref="PDB:3Q15" /db_xref="SubtiList:BG10411" /db_xref="UniProtKB/Swiss-Prot:P06628" /translation="MMNEKILIVDDQYGIRILLNEVFNKEGYQTFQAANGLQALDIVT KERPDLVLLDMKIPGMDGIEILKRMKVIDENIRVIIMTAYGELDMIQESKELGALTHF AKPFDIDEIRDAVKKYLPLKSN*" /label="spo0F CDS" gene complement(3460665..3461039) /gene="spo0F" /locus_tag="BSU_37130" /old_locus_tag="BSU37130" /label="spo0F gene" promotor_-10 complement(3461079..3461097) /Source="Nicolas_upshift_promotors" /id="U2922" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=533 /SigmaFactorBS="atgctcagaaaatgtcgtaaagtagactattataattAAAGG AAATaggaaaatcaAACAGAATACATACAATACtgcttacttttgacgaaaatcataa t" /listShort="spo0F, S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI" /listLong="S1436, rho, S1435, rpmEA, tdk" /label="promotor_-10" upshifts complement(3461093) /Source="Nicolas_upshifts" /id="U2922" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=533 /SigmaFactorBS="atgctcagaaaatgtcgtaaagtagactattataattAAAGG AAATaggaaaatcaAACAGAATACATACAATACtgcttacttttgacgaaaatcataa t" /listShort="spo0F, S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI" /listLong="S1436, rho, S1435, rpmEA, tdk" /label="upshifts" S_feature complement(3461095..3461734) /Source="Nicolas_S_feature" /locus_tag="new_3809980_3810619_c" /HighExp="dia15, Diami, dia5, G135, Etha, G150, G180, Salt, H2O2, Paraq" /AntisenseName="ywjG" /AntisenseCor="0.58536525532649697" /AntisenseRegPval="-25.4" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1440" promotor_-35 3461096..3461099 /Source="Nicolas_upshift_promotors" /id="U2923" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.456543456543457" /psig=1 /xcortree=2539 /SigmaFactorBS="aaaagtaagcagtattgtatgtattctgTTTGattttcctat ttcctTTAATTATAATAGTCTACTTtacgacattttctgagcattttctcttttgttg t" /listShort="ywjG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(3461108..3461116) /Source="Nicolas_upshift_promotors" /id="U2922" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=533 /SigmaFactorBS="atgctcagaaaatgtcgtaaagtagactattataattAAAGG AAATaggaaaatcaAACAGAATACATACAATACtgcttacttttgacgaaaatcataa t" /listShort="spo0F, S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI" /listLong="S1436, rho, S1435, rpmEA, tdk" /label="promotor_-35" promotor_-10 3461115..3461134 /Source="Nicolas_upshift_promotors" /id="U2923" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.456543456543457" /psig=1 /xcortree=2539 /SigmaFactorBS="aaaagtaagcagtattgtatgtattctgTTTGattttcctat ttcctTTAATTATAATAGTCTACTTtacgacattttctgagcattttctcttttgttg t" /listShort="ywjG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3461128 /Source="Nicolas_upshifts" /id="U2923" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.456543456543457" /psig=1 /xcortree=2539 /SigmaFactorBS="aaaagtaagcagtattgtatgtattctgTTTGattttcctat ttcctTTAATTATAATAGTCTACTTtacgacattttctgagcattttctcttttgttg t" /listShort="ywjG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3461142..3461147 /Source="Nicolas_upshift_promotors" /id="U2924" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.626373626373626" /psig="0.977022977022977" /xcortree=1775 /SigmaFactorBS="ctttaattataatagtctactttacgacaTTTTCTgagcatt ttctctttTGTTGTATACTGATATTGTAcgttataaaggaggattcacttatgttgaa a" /listShort="ywjG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3461163..3461182 /Source="Nicolas_upshift_promotors" /id="U2924" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.626373626373626" /psig="0.977022977022977" /xcortree=1775 /SigmaFactorBS="ctttaattataatagtctactttacgacaTTTTCTgagcatt ttctctttTGTTGTATACTGATATTGTAcgttataaaggaggattcacttatgttgaa a" /listShort="ywjG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3461173 /Source="Nicolas_upshifts" /id="U2924" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.626373626373626" /psig="0.977022977022977" /xcortree=1775 /SigmaFactorBS="ctttaattataatagtctactttacgacaTTTTCTgagcatt ttctctttTGTTGTATACTGATATTGTAcgttataaaggaggattcacttatgttgaa a" /listShort="ywjG" /GFF_Attribute="listLong" /label="upshifts" CDS 3461205..3461726 /gene="ywjG" /locus_tag="BSU_37140" /old_locus_tag="BSU37140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391595.1" /db_xref="EnsemblGenomes-Gn:BSU37140" /db_xref="EnsemblGenomes-Tr:CAB15731" /db_xref="InterPro:IPR019676" /db_xref="SubtiList:BG11053" /db_xref="UniProtKB/Swiss-Prot:P06629" /translation="MLKIFTTQLTGIFSRIQDKESDAIEDGARLLAQAVISGHSIYLY GANELQGVFYEATESKEPFPSVKAFPENAEEVTESDRVLMFCSGTGTAEEQELAKELY EKGAGVVCVSPAAKDSAGIEQYCDVHIDSKLKMPLVPDEDGTRYGFPSLMTALYVYHA LSFTLKEILQEYA*" /label="ywjG CDS" gene 3461205..3461726 /gene="ywjG" /locus_tag="BSU_37140" /old_locus_tag="BSU37140" /label="ywjG gene" promotor_-35 3461669..3461672 /Source="Nicolas_upshift_promotors" /id="U2925" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.936063936063936" /psig="0.99000999000999" /xcortree=1781 /SigmaFactorBS="acgggtttccctctttaatgacagcactGTATgtctatcacg ctttATCGTTTACACTAAAAGAAAttctgcaagagtatgcataatatcttattgtaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3461687..3461706 /Source="Nicolas_upshift_promotors" /id="U2925" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.936063936063936" /psig="0.99000999000999" /xcortree=1781 /SigmaFactorBS="acgggtttccctctttaatgacagcactGTATgtctatcacg ctttATCGTTTACACTAAAAGAAAttctgcaagagtatgcataatatcttattgtaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3461701 /Source="Nicolas_upshifts" /id="U2925" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.936063936063936" /psig="0.99000999000999" /xcortree=1781 /SigmaFactorBS="acgggtttccctctttaatgacagcactGTATgtctatcacg ctttATCGTTTACACTAAAAGAAAttctgcaagagtatgcataatatcttattgtaca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3461724..3461743) /Source="Nicolas_upshift_promotors" /id="U2926" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.705294705294705" /psig="0.997002997002997" /xcortree=1956 /SigmaFactorBS="ccgtttgtcaaaagcgggcaagtctttttTATTTGTTtccgg caagttccaGCATGTACAATAAGATATTAtgcatactcttgcagaatttcttttagtg t" /listShort="S1440, spo0F" /listLong="S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI, S1436, rho, S1435, rpmEA, tdk" /label="promotor_-10" upshifts complement(3461734) /Source="Nicolas_upshifts" /id="U2926" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.705294705294705" /psig="0.997002997002997" /xcortree=1956 /SigmaFactorBS="ccgtttgtcaaaagcgggcaagtctttttTATTTGTTtccgg caagttccaGCATGTACAATAAGATATTAtgcatactcttgcagaatttcttttagtg t" /listShort="S1440, spo0F" /listLong="S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI, S1436, rho, S1435, rpmEA, tdk" /label="upshifts" downshifts 3461745 /Source="Nicolas_upshifts" /id="D1920" /incds=0 /nref=191 /ntot=242 /MaxReadThrough="1.98527" /MaxDrop="5.8354" /score="11.5531593" /energy="-11.9" /TU="NA" /idTUdmin="U2923" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 complement(3461758..3461765) /Source="Nicolas_upshift_promotors" /id="U2926" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.705294705294705" /psig="0.997002997002997" /xcortree=1956 /SigmaFactorBS="ccgtttgtcaaaagcgggcaagtctttttTATTTGTTtccgg caagttccaGCATGTACAATAAGATATTAtgcatactcttgcagaatttcttttagtg t" /listShort="S1440, spo0F" /listLong="S1439, fbaA, S1438, ywjH, S1437, murAB, ywjI, S1436, rho, S1435, rpmEA, tdk" /label="promotor_-35" CDS complement(3461808..3463415) /gene="pyrG" /locus_tag="BSU_37150" /old_locus_tag="BSU37150" /EC_number="6.3.4.2" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:11544212, 15252202, 17158658, 17302819" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11544212, 15252202, 17158658, 17302819; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="CTP synthetase" /protein_id="NP_391596.1" /db_xref="EnsemblGenomes-Gn:BSU37150" /db_xref="EnsemblGenomes-Tr:CAB15743" /db_xref="GOA:P13242" /db_xref="InterPro:IPR004468" /db_xref="InterPro:IPR017456" /db_xref="InterPro:IPR017926" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR029062" /db_xref="InterPro:IPR033828" /db_xref="SubtiList:BG10410" /db_xref="UniProtKB/Swiss-Prot:P13242" /translation="MTKYIFVTGGVVSSLGKGIVAASLGRLLKNRGLNVTIQKFDPYI NVDPGTMSPYQHGEVFVTDDGAETDLDLGHYERFIDINLNKFSNVTTGKIYSTVLKKE RRGDYLGGTVQVIPHITNELKDRVYRAGKETNADVVITEIGGTVGDIESLPFLEAIRQ MKSDIGRENVMYIHCTLVPYIKAAGELKTKPTQHSVKELRSLGIQPNIIVVRTEMPIS QDMKDKIALFCDIDTKAVIECEDADNLYSIPLELQKQGLDKLVCEHMKLACKEAEMSE WKELVNKVSNLSQTITIGLVGKYVELPDAYISVVESLRHAGYAFDTDVKVKWINAEEV TENNIAELTSGTDGIIVPGGFGDRGVEGKIVATKYARENNIPFLGICLGMQVASIEYA RNVLGLKGAHSAEIDPSTQYPIIDLLPEQKDVEDLGGTLRLGLYPCKLEEGTKAFEVY QDEVVYERHRHRYEFNNEFRQQMEEQGFVFSGTSPDGRLVEIIELKDHPWFVASQFHP EFKSRPTRPQPLFKGFIGASVEAANQK*" /label="pyrG CDS" gene complement(3461808..3463415) /gene="pyrG" /locus_tag="BSU_37150" /old_locus_tag="BSU37150" /label="pyrG gene" downshifts complement(3461821) /Source="Nicolas_upshifts" /id="D1921" /incds=0 /nref=222 /ntot=259 /MaxReadThrough="2.2929" /MaxDrop="8.17874" /score="18.9699606" /energy="-12.1" /TU="NA" /idTUdmin="U2927" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(3463416..3463603) /Source="Nicolas_S_feature" /locus_tag="new_3812301_3812488_c" /HighExp="LBGexp, Lbexp, dia0, G150, G135, G180, Paraq, Oxctl, dia15, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.999, 0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1441" promotor_-10 complement(3463591..3463610) /Source="Nicolas_upshift_promotors" /id="U2927" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig="0.999000999001" /xcortree=2660 /SigmaFactorBS="taaatagtatcagatttcatcttcaaaacgaTCTTGACTttc atagtcgaactATGTAGTATGTATTTTGGGCtcttcaaaaacgaagagagaacatagt a" /listShort="S1441, pyrG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3463603) /Source="Nicolas_upshifts" /id="U2927" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig="0.999000999001" /xcortree=2660 /SigmaFactorBS="taaatagtatcagatttcatcttcaaaacgaTCTTGACTttc atagtcgaactATGTAGTATGTATTTTGGGCtcttcaaaaacgaagagagaacatagt a" /listShort="S1441, pyrG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3463625..3463632) /Source="Nicolas_upshift_promotors" /id="U2927" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig="0.999000999001" /xcortree=2660 /SigmaFactorBS="taaatagtatcagatttcatcttcaaaacgaTCTTGACTttc atagtcgaactATGTAGTATGTATTTTGGGCtcttcaaaaacgaagagagaacatagt a" /listShort="S1441, pyrG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3463657..3464178) /gene="rpoE" /locus_tag="BSU_37160" /old_locus_tag="BSU37160" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:189250, 9795209, 10336502, 10438769, 10672039, 10910724, 11029421, 23543716, 26546673, 27679485" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 189250, 9795209, 10336502, 10438769, 10672039, 10910724, 11029421, 23543716, 26546673, 27679485; Product type f: factor" /codon_start=1 /transl_table=11 /product="RNA polymerase (delta subunit) and transcriptional repressor" /protein_id="NP_391597.1" /db_xref="EnsemblGenomes-Gn:BSU37160" /db_xref="EnsemblGenomes-Tr:CAB15744" /db_xref="GOA:P12464" /db_xref="InterPro:IPR007759" /db_xref="InterPro:IPR029757" /db_xref="PDB:2KRC" /db_xref="PDB:2M4K" /db_xref="PDB:4NC7" /db_xref="PDB:4NC8" /db_xref="SubtiList:BG10409" /db_xref="UniProtKB/Swiss-Prot:P12464" /translation="MGIKQYSQEELKEMALVEIAHELFEEHKKPVPFQELLNEIASLL GVKKEELGDRIAQFYTDLNIDGRFLALSDQTWGLRSWYPYDQLDEETQPTVKAKKKKA KKAVEEDLDLDEFEEIDEDDLDLDEVEEELDLEADDFDEEDLDEDDDDLEIEEDIIDE DDEDYDDEEEEIK*" /label="rpoE CDS" gene complement(3463657..3464178) /gene="rpoE" /locus_tag="BSU_37160" /old_locus_tag="BSU37160" /label="rpoE gene" downshifts complement(3463713) /Source="Nicolas_upshifts" /id="D1922" /incds=0 /nref=7 /ntot=182 /MaxReadThrough="6.49215" /MaxDrop="3.2129" /score="19.8764263" /energy="-19.4" /TU="U2928,U2929" /idTUdmin="U2927" /TUdmin="-1892" /isTUend="FALSE" /label="downshifts" S_feature complement(3464179..3464281) /Source="Nicolas_S_feature" /locus_tag="new_3813064_3813166_c" /HighExp="H2O2, Paraq, Oxctl, LBGexp, G180, dia15, dia0, Lbexp, BMM, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1442" promotor_-10 complement(3464262..3464281) /Source="Nicolas_upshift_promotors" /id="U2928" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=2550 /SigmaFactorBS="ggatcactcttgtaaaattatttaaattaacgctgttaaggG TAGcatattctgttttatTTTGTTTATAATGAGAGGTAtggtttgtataagaacgata c" /listShort="S1442, rpoE, S1441, pyrG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3464281) /Source="Nicolas_upshifts" /id="U2928" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=2550 /SigmaFactorBS="ggatcactcttgtaaaattatttaaattaacgctgttaaggG TAGcatattctgttttatTTTGTTTATAATGAGAGGTAtggtttgtataagaacgata c" /listShort="S1442, rpoE, S1441, pyrG" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3464283..3464360) /Source="Nicolas_S_feature" /locus_tag="new_3813168_3813245_c" /HighExp="T0.30H, S8, S7, S6, S4, S3, S5, Sw, BC, Lbstat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1443" promotor_-35 complement(3464297..3464300) /Source="Nicolas_upshift_promotors" /id="U2928" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.954045954045954" /psig="0.999000999001" /xcortree=2550 /SigmaFactorBS="ggatcactcttgtaaaattatttaaattaacgctgttaaggG TAGcatattctgttttatTTTGTTTATAATGAGAGGTAtggtttgtataagaacgata c" /listShort="S1442, rpoE, S1441, pyrG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3464361..3465500) /gene="acdA" /locus_tag="BSU_37170" /old_locus_tag="BSU37170" /EC_number="1.3.99.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:17189250, 21398533" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17189250, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acyl-CoA dehydrogenase" /protein_id="NP_391598.1" /db_xref="EnsemblGenomes-Gn:BSU37170" /db_xref="EnsemblGenomes-Tr:CAB15745" /db_xref="GOA:P45867" /db_xref="InterPro:IPR006089" /db_xref="InterPro:IPR006091" /db_xref="InterPro:IPR009075" /db_xref="InterPro:IPR009100" /db_xref="InterPro:IPR013786" /db_xref="InterPro:IPR036250" /db_xref="InterPro:IPR037069" /db_xref="SubtiList:BG11239" /db_xref="UniProtKB/Swiss-Prot:P45867" /translation="MNFSLSEEHEMIRKLVRDFAKHEVAPTAAERDEQERFDRELFRE MANLGLTGIPWPEDYGGIGSDYLAYVIAVEELSKVCASTGVTLSAHISLCSWPLFAFG TEEQKTEYLTQLALGEKIGAFALTEAGSGSDAGSMKTTAERIGDDYVLNGSKVFITNG GVADIYIVFAVTDPEKKKKGVTAFIVEKDFEGFFTGKKEKKLGIRSSPTTEIMFEDCV VPASKRLGEEGEGFKIAMKTLDGGRNGIAAQAVGIAQGALDAALQYAKERKQFGKSIA EQQGIAFKLADMATMIEASRLLTYQAAWLESSGLPYGKASAMSKLMAGDTAMKVTTEA VQIFGGYGYTKDYPVERYMRDAKITQIYEGTQEIQRLVISRMLAD*" /label="acdA CDS" gene complement(3464361..3465500) /gene="acdA" /locus_tag="BSU_37170" /old_locus_tag="BSU37170" /label="acdA gene" CDS complement(3465497..3467614) /gene="fadF" /locus_tag="BSU_37180" /old_locus_tag="BSU37180" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17189250, 21398533; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative iron-sulphur-binding reductase" /protein_id="NP_391599.1" /db_xref="EnsemblGenomes-Gn:BSU37180" /db_xref="EnsemblGenomes-Tr:CAB15746" /db_xref="GOA:P45866" /db_xref="InterPro:IPR004017" /db_xref="InterPro:IPR009051" /db_xref="InterPro:IPR017896" /db_xref="InterPro:IPR017900" /db_xref="InterPro:IPR036197" /db_xref="SubtiList:BG11311" /db_xref="UniProtKB/Swiss-Prot:P45866" /translation="MSGFLIANALLFLIVTAYAVYLFVYLVKTRLAYIKLGQKEQFDQ RFKERLHAIWVNVFGQKKLLKDKKSGIIHVMFFYGFILVQFGAIDFIIKGLAPGRNLS LGPVYPAFTFFQEIVTFLILIAVGWAFYRRYIEKLVRLKRGFKAGLVLIFIGGLMLTV LLGNGMNLIWHEHGLSWSEPIASGIAFMLSGVGKTGAAVIFYIAWWIHLLFLLSFLVY VPQSKHAHLIAGPANVFFNRMESAGKLEKIDFTDETKESYGAGKIEDFRQSQLLDLYA CVECGRCTNMCPATGTGKMLSPMDLILRLRDHLTEKGAAVTSRSPWVPAAAFRHTRGN QLAAASAGSGSQEAAAALDYNPSLIGDVITEEEIWACTTCRNCEDQCPVMNEHVDKII DLRRYLVLTEGKMDSDAQRAMTSIERQGNPWGLNRKERENWRDEAPDAEIPTVKEMKK EGKEFEYLFWVGSMGSYDNRSQKIAISFAKLLNHAGVSFAILGNKEKNSGDTPRRLGN EFLFQELAEKNISEFEKNDVKKIVTIDPHAYNLFKNEYPDFGFEGEVYHHTEVLAELV KNGKLRPQHPLHETITFHDSCYLGRYNEVYDPPREILKAIPGVQLVEMERSRETGMCC GAGGGLMWMEEETGNRINVARTEQALAVNPSVISSGCPYCLTMLGDGTKAKEAEDQVK TYDVVELLAQSVLGADLKMGEKQ*" /label="fadF CDS" gene complement(3465497..3467614) /gene="fadF" /locus_tag="BSU_37180" /old_locus_tag="BSU37180" /label="fadF gene" S_feature complement(3467615..3467673) /Source="Nicolas_S_feature" /locus_tag="new_3816500_3816558_c" /HighExp="T0.30H, S6, BC, S8, S7, Sw, S5, S4, Lbstat, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1444" promotor_-10 complement(3467674..3467693) /Source="Nicolas_upshift_promotors" /id="U2929" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.526473526473527" /psig=1 /xcortree=373 /SigmaFactorBS="aaaggtagtgtgcccgaacagcaggaatttaatTATTGACTg aacactcattcaTTATTTATCATAAAGATAATcttatacagattcgggggtaggggat c" /listShort="S1444, fadF, acdA, S1443, S1442, rpoE, S1441, pyrG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3467687) /Source="Nicolas_upshifts" /id="U2929" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.526473526473527" /psig=1 /xcortree=373 /SigmaFactorBS="aaaggtagtgtgcccgaacagcaggaatttaatTATTGACTg aacactcattcaTTATTTATCATAAAGATAATcttatacagattcgggggtaggggat c" /listShort="S1444, fadF, acdA, S1443, S1442, rpoE, S1441, pyrG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3467707..3467714) /Source="Nicolas_upshift_promotors" /id="U2929" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.526473526473527" /psig=1 /xcortree=373 /SigmaFactorBS="aaaggtagtgtgcccgaacagcaggaatttaatTATTGACTg aacactcattcaTTATTTATCATAAAGATAATcttatacagattcgggggtaggggat c" /listShort="S1444, fadF, acdA, S1443, S1442, rpoE, S1441, pyrG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3467713..3467719 /Source="Nicolas_upshift_promotors" /id="U2930" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=886 /SigmaFactorBS="tctttatgataaataatgaatgagtgttcagtcaaTAATTAA attcctgctgttcGGGCACACTACCtttactacggaaaggagtgccggtatgaaggta t" /listShort="clsB, ywjD, ywjC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3467733..3467744 /Source="Nicolas_upshift_promotors" /id="U2930" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=886 /SigmaFactorBS="tctttatgataaataatgaatgagtgttcagtcaaTAATTAA attcctgctgttcGGGCACACTACCtttactacggaaaggagtgccggtatgaaggta t" /listShort="clsB, ywjD, ywjC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3467738 /Source="Nicolas_upshifts" /id="U2930" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=886 /SigmaFactorBS="tctttatgataaataatgaatgagtgttcagtcaaTAATTAA attcctgctgttcGGGCACACTACCtttactacggaaaggagtgccggtatgaaggta t" /listShort="clsB, ywjD, ywjC" /GFF_Attribute="listLong" /label="upshifts" CDS 3467769..3468965 /gene="clsB" /locus_tag="BSU_37190" /old_locus_tag="BSU37190" /EC_number="2.7.8.-" /function="16.8: Protect" /function="16.13: Shape" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:14973018, 16514141, 18820022" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14973018, 16514141, 18820022; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="minor cardiolipin synthetase (phospholipase D family)" /protein_id="NP_391600.1" /db_xref="EnsemblGenomes-Gn:BSU37190" /db_xref="EnsemblGenomes-Tr:CAB15747" /db_xref="GOA:P45865" /db_xref="InterPro:IPR001736" /db_xref="InterPro:IPR022924" /db_xref="InterPro:IPR025202" /db_xref="SubtiList:BG11310" /db_xref="UniProtKB/Swiss-Prot:P45865" /translation="MKVFIVIMIIVVIFFALILLDIFMGRAGYRKKAYEPVFSKKKSD IELIHCGADLVERMMNDIRQAASSVHMMFFIMKNDEVSHNMYTLLKTKAQAGVSVYLL LDWAGCRAIKKTALQTMKNAGVHVHVMNRPRFPFFFFHMQKRNHRKITVIDGKIGYIG GFNIAEEYLGKKAKFGNWEDYHLRMIGEGVHDLQTLFASDLKRNTGIELGSDVWPKLQ QGTISHKIYATDGYSLENIYLANIAQAKNRLTVCTPYYIPSKPLQEALINARKNGVSV RIIVPMKSDHPLVREAAFTYYSELLDAGCLIYRYYQGFYHVKALIIDDHLSIIGTANF DKRSLFLNEEVNVEIDDEAFTSEVYATIEEDMKKSELLTMEDFSKRTFRQRPAEWLGR ALSYFL*" /label="clsB CDS" gene 3467769..3468965 /gene="clsB" /locus_tag="BSU_37190" /old_locus_tag="BSU37190" /label="clsB gene" S_feature complement(3467961..3468839) /Source="Nicolas_S_feature" /locus_tag="new_3816846_3817724_c" /HighExp="S4, S5, S3, S6, S7, S8, BT, B36, LoTm, B60" /AntisenseName="clsB" /AntisenseCor="0.84883232203587" /AntisenseRegPval="-75.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1445" promotor_-10 complement(3468829..3468847) /Source="Nicolas_upshift_promotors" /id="U2931" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1122 /SigmaFactorBS="tgaaatcctccatcgtcagcagctccgactttTTCATAtcct cctcaattgtgGCATAGACTTCACTTGTAAacgcttcgtcatcaatttcaacattcac c" /listShort="S1445" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3468840) /Source="Nicolas_upshifts" /id="U2931" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1122 /SigmaFactorBS="tgaaatcctccatcgtcagcagctccgactttTTCATAtcct cctcaattgtgGCATAGACTTCACTTGTAAacgcttcgtcatcaatttcaacattcac c" /listShort="S1445" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3468863..3468868) /Source="Nicolas_upshift_promotors" /id="U2931" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1122 /SigmaFactorBS="tgaaatcctccatcgtcagcagctccgactttTTCATAtcct cctcaattgtgGCATAGACTTCACTTGTAAacgcttcgtcatcaatttcaacattcac c" /listShort="S1445" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3468978..3469940 /gene="uvsE" /locus_tag="BSU_37200" /old_locus_tag="BSU37200" /EC_number="3.-.-.-" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:8614629, 22961846" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8614629, 22961846; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UV DNA damage repair endonuclease" /protein_id="NP_391601.1" /db_xref="EnsemblGenomes-Gn:BSU37200" /db_xref="EnsemblGenomes-Tr:CAB15748" /db_xref="GOA:P45864" /db_xref="InterPro:IPR004601" /db_xref="InterPro:IPR023520" /db_xref="InterPro:IPR036237" /db_xref="SubtiList:BG11309" /db_xref="UniProtKB/Swiss-Prot:P45864" /translation="MIFRFGFVSNAMSLWDASPAKTLTFARYSKLSKTERKEALLTVT KANLRNTMRTLHYIIGHGIPLYRFSSSIVPLATHPDVMWDFVTPFQKEFREIGELVKT HQLRTSFHPNQFTLFTSPKESVTKNAVTDMAYHYRMLEAMGIADRSVINIHIGGAYGN KDTATAQFHQNIKQLPQEIKERMTLENDDKTYTTEETLQVCEQEDVPFVFDFHHFYAN PDDHADLNVALPRMIKTWERIGLQPKVHLSSPKSEQAIRSHADYVDANFLLPLLERFR QWGTNIDFMIEAKQKDKALLRLMDELSSIRGVKRIGGGALQWKS*" /label="uvsE CDS" gene 3468978..3469940 /gene="uvsE" /locus_tag="BSU_37200" /old_locus_tag="BSU37200" /label="uvsE gene" promotor_-35 3469954..3469960 /Source="Nicolas_upshift_promotors" /id="U2932" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=217 /SigmaFactorBS="gcggtgcgctgcaatggaagtcataaatgtgcaaaaataGGT TTACgacttgtcagctttGGGAACTTAGGCTATATAAgacaacaatcgatggaggaga a" /listShort="ywjC, S1446" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3469975..3469993 /Source="Nicolas_upshift_promotors" /id="U2932" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=217 /SigmaFactorBS="gcggtgcgctgcaatggaagtcataaatgtgcaaaaataGGT TTACgacttgtcagctttGGGAACTTAGGCTATATAAgacaacaatcgatggaggaga a" /listShort="ywjC, S1446" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3469975 /Source="Nicolas_upshifts" /id="U2932" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=217 /SigmaFactorBS="gcggtgcgctgcaatggaagtcataaatgtgcaaaaataGGT TTACgacttgtcagctttGGGAACTTAGGCTATATAAgacaacaatcgatggaggaga a" /listShort="ywjC, S1446" /GFF_Attribute="listLong" /label="upshifts" CDS 3470021..3470293 /gene="ywjC" /locus_tag="BSU_37210" /old_locus_tag="BSU37210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391602.1" /db_xref="EnsemblGenomes-Gn:BSU37210" /db_xref="EnsemblGenomes-Tr:CAB15749" /db_xref="InterPro:IPR035895" /db_xref="SubtiList:BG11308" /db_xref="UniProtKB/Swiss-Prot:P45863" /translation="MKNIKSLKVAAQAFTLRNLIHLYKMCHSGSHEVYIYSKKTMCKI KSLIELETFRMAHNEKEYLIVVEGTKASQLIEKFQNLIEPAEREAL*" /label="ywjC CDS" gene 3470021..3470293 /gene="ywjC" /locus_tag="BSU_37210" /old_locus_tag="BSU37210" /label="ywjC gene" downshifts complement(3470027) /Source="Nicolas_upshifts" /id="D1923" /incds=0 /nref=4 /ntot=17 /MaxReadThrough="1.03516" /MaxDrop="5.08765" /score="17.8471239" /energy="-10" /TU="NA" /idTUdmin="U2933" /TUdmin=330 /isTUend="FALSE" /label="downshifts" downshifts 3470283 /Source="Nicolas_upshifts" /id="D1924" /incds=0 /nref=54 /ntot=128 /MaxReadThrough="4.49396" /MaxDrop="7.49636" /score="14.0189582" /energy="-10" /TU="U2932" /idTUdmin="U2930" /TUdmin=178 /isTUend="FALSE" /label="downshifts" S_feature 3470328..3470734 /Source="Nicolas_S_feature" /locus_tag="new_3819213_3819619" /HighExp="Etha, C30, Sw, Gly, C90, M/G, BC, Salt, Fru, G135" /AntisenseName="ywjB" /AntisenseCor="0.2646821361217" /AntisenseRegPval="-5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1446" CDS complement(3470335..3470859) /gene="ywjB" /locus_tag="BSU_37220" /old_locus_tag="BSU37220" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12354229, 27795321; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391603.1" /db_xref="EnsemblGenomes-Gn:BSU37220" /db_xref="EnsemblGenomes-Tr:CAB15750" /db_xref="GOA:P45862" /db_xref="InterPro:IPR002734" /db_xref="InterPro:IPR024072" /db_xref="SubtiList:BG11307" /db_xref="UniProtKB/Swiss-Prot:P45862" /translation="MERKTVLYIAVSLDGMIAKEDGSIDWLDEFEGEGDNGYSDFYQT VDTVILGRSTYEHVKVLTPVFPYQDKTCYVFTGSPDSYQDEHVTFINEGARAFTARLK QEKGSNIWIAGGAELVNDFMKEDAIDEFIITVIPVVLGSGIPLFHELTNETKLRLKGT KQFGQAVQLHYVRA*" /label="ywjB CDS" gene complement(3470335..3470859) /gene="ywjB" /locus_tag="BSU_37220" /old_locus_tag="BSU37220" /label="ywjB gene" downshifts complement(3470357) /Source="Nicolas_upshifts" /id="D1925" /incds=0 /nref=194 /ntot=239 /MaxReadThrough="1.38978" /MaxDrop="6.19859" /score="17.8471239" /energy="-10" /TU="NA" /idTUdmin="U2933" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3470869..3472596) /gene="ywjA" /locus_tag="BSU_37230" /old_locus_tag="BSU37230" /EC_number="3.6.3.-" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12119303, 12354229, 25652542; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC lipid transporter (ATP-binding protein)" /protein_id="NP_391604.1" /db_xref="EnsemblGenomes-Gn:BSU37230" /db_xref="EnsemblGenomes-Tr:CAB15751" /db_xref="GOA:P45861" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG11306" /db_xref="UniProtKB/Swiss-Prot:P45861" /translation="MLRQFFSYYKPYKTLFFLDFFSAIAGGLMELSFPLIVNYFIDTL LPGRDWGLIIATSIGLFAVYALSSALQYIVTYWGHMLGINIETDMRKSLFDHLQKLSF KFYDNNKTGTLMSKLTNDLMYIGEVAHHGPEDLFIAVMTILGAFGVMLFINWQLALLT FIIMPIVIWLALYFNKKMTKAFTTLNKDIGDFSARVENNIGGIRLVQAFGNEAFEKER FAVNNQRFRVTKLSSYKIMAKNGSISYMLTRFVTLFVLLCGTWFVIRGSLSYGEFVAF VLLTNVLFRPIDKINAIIEMYPRGIAGFKSYMELMETEPDIQDSPDSKDVSGLKGNIR YKHVSFGYDDHHNVLNDINLSIQAGETVAFVGPSGAGKSTLCSLLPRFYEASEGDITI DGISIKDMTLSSLRGQIGVVQQDVFLFSGTLRENIAYGRLGASEEDIWQAVKQAHLEE LVHNMPDGLDTMIGERGVKLSGGQKQRLSIARMFLKNPSILILDEATSALDTETEAAI QKALQELSEGRTTLVIAHRLATIKDADRIVVVTNNGIEEQGRHQDLIEAGGLYSRLHQ AQFGQMVHR*" /label="ywjA CDS" gene complement(3470869..3472596) /gene="ywjA" /locus_tag="BSU_37230" /old_locus_tag="BSU37230" /label="ywjA gene" promotor_-10 complement(3472630..3472649) /Source="Nicolas_upshift_promotors" /id="U2933" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.397602397602398" /psig="0.999000999001" /xcortree=2106 /SigmaFactorBS="tgttttcaggtgttctgtaagaaaaaagaaatctgATCTTAC aaaacagcccgtgTATAGTATAATTGAGAAATAttatcagttatttatacattggggg a" /listShort="ywjA, ywjB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3472644) /Source="Nicolas_upshifts" /id="U2933" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.397602397602398" /psig="0.999000999001" /xcortree=2106 /SigmaFactorBS="tgttttcaggtgttctgtaagaaaaaagaaatctgATCTTAC aaaacagcccgtgTATAGTATAATTGAGAAATAttatcagttatttatacattggggg a" /listShort="ywjA, ywjB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3472663..3472669) /Source="Nicolas_upshift_promotors" /id="U2933" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.397602397602398" /psig="0.999000999001" /xcortree=2106 /SigmaFactorBS="tgttttcaggtgttctgtaagaaaaaagaaatctgATCTTAC aaaacagcccgtgTATAGTATAATTGAGAAATAttatcagttatttatacattggggg a" /listShort="ywjA, ywjB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3472685..3474187) /gene="clsC" /locus_tag="BSU_37240" /old_locus_tag="BSU37240" /EC_number="2.7.8.-" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 14973018, 15743965, 16514141, 26025016; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="minor cardiolipin synthetase" /protein_id="NP_391605.1" /db_xref="EnsemblGenomes-Gn:BSU37240" /db_xref="EnsemblGenomes-Tr:CAB15752" /db_xref="GOA:P45860" /db_xref="InterPro:IPR001736" /db_xref="InterPro:IPR022924" /db_xref="InterPro:IPR025202" /db_xref="InterPro:IPR027379" /db_xref="InterPro:IPR030874" /db_xref="SubtiList:BG11305" /db_xref="UniProtKB/Swiss-Prot:P45860" /translation="MLKRRLEFFFLYMMLIGAYVIWFFPVSRLEFYGGLLCYISIILF SIYSLILENRTSQHTLLWIHILVFFPIVGYVFYLFSGQLYVKGKLFKTKRMYNREKLR KLFDKEETPEVTGLKDNQERFFTYSIRAAHMNINTKSNIKVLKNGEETFPDIFKAMRK AESYIHIEYYMFKSDMLGRGMMDIMMEKARQGVEVRFLYDAAGSMKLARRDIMRMKQA GVDIVPFSPLKYGFFNQKLNFRNHRKIVIIDGKTGFVGGLNVGKEYISRDPYIGFWRD THLRLEGEIVQTLHAIFMLDWEYVSNEVLIDQEEYNTPVPVEGGGIYQIVATGPDMKE SMSDLYYEMISSAQKSIWIATPYFVPNESIRTALKAAATKGVEVRVMVPEKNDSFLTQ YASRSYFPELLLEGIEVYSYQKGFMHQKVMIIDGDLASVGTANMDMRSFQLNFEVNVF FTDAEAIRTLEAHFEEDMQESEKLSPVGFYKRGVADRTKESFARLFSGVL*" /label="clsC CDS" gene complement(3472685..3474187) /gene="clsC" /locus_tag="BSU_37240" /old_locus_tag="BSU37240" /label="clsC gene" promotor_-10 complement(3474211..3474229) /Source="Nicolas_upshift_promotors" /id="U2934" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=216 /SigmaFactorBS="aacctctcctcctttggcggagaggttttttacttacaaGGT TTATcgattagaaaaaagAGGTAATACAGAGGTAATTgaatcagattggagagaatca g" /listShort="ywiE, ywjA, ywjB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3474229) /Source="Nicolas_upshifts" /id="U2934" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=216 /SigmaFactorBS="aacctctcctcctttggcggagaggttttttacttacaaGGT TTATcgattagaaaaaagAGGTAATACAGAGGTAATTgaatcagattggagagaatca g" /listShort="ywiE, ywjA, ywjB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3474244..3474250) /Source="Nicolas_upshift_promotors" /id="U2934" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=216 /SigmaFactorBS="aacctctcctcctttggcggagaggttttttacttacaaGGT TTATcgattagaaaaaagAGGTAATACAGAGGTAATTgaatcagattggagagaatca g" /listShort="ywiE, ywjA, ywjB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3474274..3474646) /Source="Nicolas_S_feature" /locus_tag="new_3823159_3823531_c" /HighExp="Lbtran, M40t45, nit, LBGtran, LBGstat, S0, ferm, M0t45, Lbstat, BI" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.30294500000000002" /TUshortSig="SigA" /TUshortPSig="0.993" /TUlongSig="SigA" /TUlongPSig="0.996" /label="S1447" downshifts complement(3474317) /Source="Nicolas_upshifts" /id="D1926" /incds=0 /nref=4 /ntot=19 /MaxReadThrough="2.94229" /MaxDrop="4.09744" /score="13.5274489" /energy="-11.4" /TU="NA" /idTUdmin="U2935" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3474673..3475344) /gene="narI" /locus_tag="BSU_37250" /old_locus_tag="BSU37250" /EC_number="1.7.99.4" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:7557333, 7860592, 8846791, 11289299, 15849754, 16850406, 22103536" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7557333, 7860592, 8846791, 11289299, 15849754, 16850406, 22103536; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nitrate reductase (gamma subunit)" /protein_id="NP_391606.1" /db_xref="EnsemblGenomes-Gn:BSU37250" /db_xref="EnsemblGenomes-Tr:CAB15753" /db_xref="GOA:P42177" /db_xref="InterPro:IPR003816" /db_xref="InterPro:IPR023234" /db_xref="InterPro:IPR036197" /db_xref="SubtiList:BG11084" /db_xref="UniProtKB/Swiss-Prot:P42177" /translation="MSGQILWGIMPYIVLTIFIGGHIYRYQHDQFGWTAKSSELLEKK KLAAGSTLFHWGLLCVVGGHVMGILIPEGVYASLGISEHMYHKMAIGAGLPAGIAACT GLVILTYRRLFDKRIRKTSSPSDILTLLLLLFMMLSGVAATFLNIDSKGFDYRTTVGP WFREIVLFRPDASLMESVPLWFKFHIVIGYVVFILWPFTRLVHVFSLPLKYLTRSYVV YRKRS*" /label="narI CDS" gene complement(3474673..3475344) /gene="narI" /locus_tag="BSU_37250" /old_locus_tag="BSU37250" /label="narI gene" downshifts complement(3474691) /Source="Nicolas_upshifts" /id="D1927" /incds=0 /nref=4 /ntot=13 /MaxReadThrough="6.70789" /MaxDrop="4.50566" /score="27.8375931" /energy="-11.7" /TU="U2935" /idTUdmin="U2935" /TUdmin="-374" /isTUend="FALSE" /label="downshifts" CDS complement(3475341..3475895) /gene="narJ" /locus_tag="BSU_37260" /old_locus_tag="BSU37260" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:7557333, 7860592, 8846791, 11289299" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7557333, 7860592, 8846791, 11289299; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nitrate reductase molybdenum cofactor assembly chaperone NarJ" /protein_id="NP_391607.1" /db_xref="EnsemblGenomes-Gn:BSU37260" /db_xref="EnsemblGenomes-Tr:CAB15754" /db_xref="GOA:P42178" /db_xref="InterPro:IPR003765" /db_xref="InterPro:IPR020945" /db_xref="InterPro:IPR036411" /db_xref="SubtiList:BG11083" /db_xref="UniProtKB/Swiss-Prot:P42178" /translation="MNTTDRQITFSALSCLLSYPDEEWRAELPDWKALIQEIGNRQIR EKLLHFFETSASYSPEALIEHYVYTFDFGKKTNMYVTYFNSGEQRERGIELLHLKNTY EQSGFLPTEKELPDYLPLMLEFAAAAEIEAARSVFEKYLSNVRELASRLEKNDSIYAE LLHVLLAALENIGVRESVEGAVQA*" /label="narJ CDS" gene complement(3475341..3475895) /gene="narJ" /locus_tag="BSU_37260" /old_locus_tag="BSU37260" /label="narJ gene" CDS complement(3475921..3477384) /gene="narH" /locus_tag="BSU_37270" /old_locus_tag="BSU37270" /EC_number="1.7.99.4" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:7557333, 7860592, 8846791, 11289299, 15849754, 16850406, 22103536" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7557333, 7860592, 8846791, 11289299, 15849754, 16850406, 22103536; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nitrate reductase (beta subunit)" /protein_id="NP_391608.1" /db_xref="EnsemblGenomes-Gn:BSU37270" /db_xref="EnsemblGenomes-Tr:CAB15755" /db_xref="GOA:P42176" /db_xref="InterPro:IPR006547" /db_xref="InterPro:IPR017896" /db_xref="InterPro:IPR029263" /db_xref="SubtiList:BG11082" /db_xref="UniProtKB/Swiss-Prot:P42176" /translation="MKIKAQIGMVMNLDKCIGCHTCSVTCKNTWTNRSGAEYMYFNNV ETKPGIGYPKQWEDQDKYKGGWTLKKGKLELKSGSKTNRLAGLFYNPNQPSIDDYYEP WNYDYETLTNSPQKKHQPVARPKSSLTGDFMNIEWGPNWEDDLAGGHITGLEDPNVQK MEESIKTEFDDVFMMYLPRICEHCINPACVSSCPSGAMYKREEDGIVLVDQNACRSWR YCVSSCPYKKVYFNWQTNKAEKCTLCFPRLEAGLPTICSETCVGRIRYLGVMLYDADK VEEAASVENEKDLYHSQLDVFLDPNDPEVAKLAKEQGIPAEWIEAAQQSPIYKMIIDW KIALPLHPEYRTLPMVWYIPPLSPIMNLFEGKGSRQTAEDIFPAIDQMRIPIDYLAQL LTAGDTDHIRSTLKKMSVMRQYMRAVQTNKSIDPELISSVGLTEQQIEDMYRLLAIAK YDDRFVIPSSHREEVSDLYAEQGSCGLSFSGGPGSCF*" /label="narH CDS" gene complement(3475921..3477384) /gene="narH" /locus_tag="BSU_37270" /old_locus_tag="BSU37270" /label="narH gene" CDS complement(3477374..3481060) /gene="narG" /locus_tag="BSU_37280" /old_locus_tag="BSU37280" /EC_number="1.7.5.1" /EC_number="1.7.99.4" /function="16.10: Respire" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11289299, 7557333, 7860592, 8846791; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="nitrate reductase (alpha subunit)" /protein_id="NP_391609.2" /db_xref="EnsemblGenomes-Gn:BSU37280" /db_xref="EnsemblGenomes-Tr:CAB15756" /db_xref="GOA:P42175" /db_xref="InterPro:IPR006468" /db_xref="InterPro:IPR006655" /db_xref="InterPro:IPR006656" /db_xref="InterPro:IPR006657" /db_xref="InterPro:IPR006963" /db_xref="InterPro:IPR009010" /db_xref="InterPro:IPR027467" /db_xref="InterPro:IPR028189" /db_xref="SubtiList:BG11081" /db_xref="UniProtKB/Swiss-Prot:P42175" /translation="MKKKKRSPLFRRLNYFSPIEHHSNKHSQTTREDRDWENVYRNRW QYDKVVRSTHGVNCTGSCSWNIYVKNGIVTWEGQNLNYPSTGPDMPDFEPRGCPRGAS FSWYIYSPLRVKYPYVRGVLINLWREALQTHQNPLEAWKSIVENPEKAKSYKQARGKG GFVRAEWPEVLKLISASLLYTVMKYGPDRNVGFSPIPAMSMISHASGSRFMSLIGGPM LSFYDWYADLPPASPQIWGDQTDVPESSDWYNSGYIITWGSNVPLTRTPDAHFLAEAR YKGAKVISISPDFAESSKFADDWLSIRQGTDGALAMAMGHVILQEFYVNQETERFIEY AKQYTDFPFLVTLSKENGVYTAGRFLHAKDIGRKTKHDQWKPAVWDEQTSSFAIPQGT MGSRWDGQQKWNLHMIDEETGEPIEPRLSVLGIEDEIGTVRIPYFSNDGNKVLERDLP IKKMNLNGEETYITTVFDLILANYGVNRGIGERSAVSYDDPEPFTPAWQEQMTGIKKE AVVKIAREFAQNAIDTDGRSMIIVGAGINHWFNSDTIYRAVLNLVLLVGAQGVNGGGW AHYVGQEKLRPAEGWQTIATAKDWEGVPKLQNGTSFFYFATDQWRYEDQPISDLASPI AASSRYKHHADYNVLAARLGWLPSYPTFNQNGIDLYKEAEKAGAATPEDVGAYVASQL QEKKLKFAIEDPDNEVNFPRNLFVWRANLISSSGKGHEYFLKHLLGTTNGLMNDDSDS IRPEEIKWREQAPEGKLDLLINLDFRMAGTALYSDIVLPAATWYEKHDLSSTDMHPFI HPFAPAISAPWESKSDWDIFKALSKAVSDLAEEVDMEPVKEVVATPLLHDTMQELAQP FGKINDWSKGECEAIPGKTMPNIQVVERDYKHIFHKMTALGPNVALKPSGTKGMSWSI ADEYESLKQRLGEITSDSVAKGCPNISEAKQAAEAILTLSSTSNGKVAVKAWESLENI TNLKLKDLAEEREEECFTFEQITAQPKTVITSPAFTGSEKGGRRYSPFTTNVEKLIPW RTLTGRQSYYVDHELMMEFGETMATFKPILQHRPFLSKRPDQEGKEIVLNYLTPHNKW SVHSMYFDSLPMLTLFRGGPTVWMNKDDAEDTDIKDNDWIECFNRNGVVVARAVLSHR IPKGMAFMHHAQDRHINVPGTKLTNNRGGTHNSPTRIHVKPTQMIGGYAQLSYGFNYY GPTGNQRDLNVVIRKLKEVDWLED*" /label="narG CDS" gene complement(3477374..3481060) /gene="narG" /locus_tag="BSU_37280" /old_locus_tag="BSU37280" /label="narG gene" misc_feature complement(3481091..3481110) /Source="Nicolas_upshift_promotors" /id="U2935" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.971028971028971" /psig="0.993006993006993" /xcortree=1614 /SigmaFactorBS="ctttgtgtgaacattttgtgaaaaaagcagagtgtgtgacat agttcacaaggaaacacgctgtcTCTGTTTATAGTGAACTTAGcatcacctgactcgg a" /listShort="narG, narH, narJ, narI, S1447" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3481115) /Source="Nicolas_upshifts" /id="U2935" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.971028971028971" /psig="0.993006993006993" /xcortree=1614 /SigmaFactorBS="ctttgtgtgaacattttgtgaaaaaagcagagtgtgtgacat agttcacaaggaaacacgctgtcTCTGTTTATAGTGAACTTAGcatcacctgactcgg a" /listShort="narG, narH, narJ, narI, S1447" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3481117..3481246) /Source="Nicolas_S_feature" /locus_tag="new_3830002_3830131_c" /HighExp="Lbtran, M40t45, LBGtran, ferm, M0t45, nit, S0, Lbstat, LBGstat, M0t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1448" CDS complement(3481256..3481732) /gene="arfM" /locus_tag="BSU_37290" /old_locus_tag="BSU37290" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10809684, 11698370, 16428414, 22178965" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10809684, 11698370, 16428414, 22178965; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator" /protein_id="NP_391610.1" /db_xref="EnsemblGenomes-Gn:BSU37290" /db_xref="EnsemblGenomes-Tr:CAB15757" /db_xref="GOA:P46910" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR018490" /db_xref="SubtiList:BG11345" /db_xref="UniProtKB/Swiss-Prot:P46910" /translation="MNQCDYLLFLKQLPMFNEVPLSIVETLLKNGTFIRGSCDQSPSF LHSQSVYIVLKGSVRFMDTRLPEGSKTVALWEKGDVFPIDEKGGLYLSPFISVNATSD ILILNIPYYIFKKMMSYHPQLQMNFLAMLQQNVFCSYQLFLRYLHTSQDENAEPGS*" /label="arfM CDS" gene complement(3481256..3481732) /gene="arfM" /locus_tag="BSU_37290" /old_locus_tag="BSU37290" /label="arfM gene" downshifts complement(3481291) /Source="Nicolas_upshifts" /id="D1928" /incds=0 /nref=10 /ntot=39 /MaxReadThrough="5.03469" /MaxDrop="3.83412" /score="30.7487171" /energy="-10.5" /TU="U2936" /idTUdmin="U2936" /TUdmin="-154" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3481755..3481774) /Source="Nicolas_upshift_promotors" /id="U2936" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.72927072927073" /psig="0.996003996003996" /xcortree=1613 /SigmaFactorBS="aagtgacattcatcatacaggctgtgaaatacatcACTGctg tacaggctcagTCGAGCTACACTAAAGCTATccttagcacaggaggttttcctatgaa t" /listShort="arfM, S1448" /listLong="narG, narH, narJ, narI, S1447" /label="promotor_-10" upshifts complement(3481767) /Source="Nicolas_upshifts" /id="U2936" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.72927072927073" /psig="0.996003996003996" /xcortree=1613 /SigmaFactorBS="aagtgacattcatcatacaggctgtgaaatacatcACTGctg tacaggctcagTCGAGCTACACTAAAGCTATccttagcacaggaggttttcctatgaa t" /listShort="arfM, S1448" /listLong="narG, narH, narJ, narI, S1447" /label="upshifts" promotor_-35 complement(3481789..3481792) /Source="Nicolas_upshift_promotors" /id="U2936" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.72927072927073" /psig="0.996003996003996" /xcortree=1613 /SigmaFactorBS="aagtgacattcatcatacaggctgtgaaatacatcACTGctg tacaggctcagTCGAGCTACACTAAAGCTATccttagcacaggaggttttcctatgaa t" /listShort="arfM, S1448" /listLong="narG, narH, narJ, narI, S1447" /label="promotor_-35" upshifts 3481839 /Source="Nicolas_upshifts" /id="U2937" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=1612 /SigmaFactorBS="gcctgtacagcagtgatgtatttcacagcctgtatgatgaat gtcacttatcaggagggtgaaTGCATTTATAATGAAAGAAAaaaggaggatttcgatg a" /listShort="ywiC" /GFF_Attribute="listLong" /label="upshifts" misc_feature 3481842..3481861 /Source="Nicolas_upshift_promotors" /id="U2937" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.988011988011988" /psig=1 /xcortree=1612 /SigmaFactorBS="gcctgtacagcagtgatgtatttcacagcctgtatgatgaat gtcacttatcaggagggtgaaTGCATTTATAATGAAAGAAAaaaggaggatttcgatg a" /listShort="ywiC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 3481876..3482595 /gene="ywiC" /locus_tag="BSU_37300" /old_locus_tag="BSU37300" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16428414, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391611.1" /db_xref="EnsemblGenomes-Gn:BSU37300" /db_xref="EnsemblGenomes-Tr:CAB15758" /db_xref="GOA:P46909" /db_xref="InterPro:IPR025576" /db_xref="SubtiList:BG11344" /db_xref="UniProtKB/Swiss-Prot:P46909" /translation="MKALIPKQHGAWAMLLIPFLLGMVKGGPVIWHIPLFLGWLFLYL AVYPVTLALKKKQSKPYQKWMCYYGFPTCCFLMISVFHKPPLIWVGVSLLPLFLIHMY FARRKNERALLNDVAGVLFFCSGGFASCWLGMGTLDGWAWFIFLQSALFFIGSSFYVK SVIRERKNRAFAYWSWGYHLLLPFLSALFGAGWAFLAFIPSSLRAWFFHGRDWPVKTI GILEIVNACFFLAVMCLFITR*" /label="ywiC CDS" gene 3481876..3482595 /gene="ywiC" /locus_tag="BSU_37300" /old_locus_tag="BSU37300" /label="ywiC gene" downshifts 3482579 /Source="Nicolas_upshifts" /id="D1929" /incds=0 /nref=14 /ntot=34 /MaxReadThrough="2.00369" /MaxDrop="5.63285" /score="-3.54009378" /energy="-5.8" /TU="NA" /idTUdmin="U2937" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3482627..3483343) /gene="fnr" /locus_tag="BSU_37310" /old_locus_tag="BSU37310" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8682783, 8846791, 16796679, 21068385, 23046954" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8682783, 8846791, 16796679, 21068385, 23046954; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of anaerobic metabolism (FNR/CAP family)" /protein_id="NP_391612.1" /db_xref="EnsemblGenomes-Gn:BSU37310" /db_xref="EnsemblGenomes-Tr:CAB15759" /db_xref="GOA:P46908" /db_xref="InterPro:IPR000595" /db_xref="InterPro:IPR012318" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR018335" /db_xref="InterPro:IPR018490" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11343" /db_xref="UniProtKB/Swiss-Prot:P46908" /translation="MNFLSVRPSDSDLISSDLYELLESISTKRKMEKHTYLFREGMDA EELYLIQSGLIEIGKLTSDGKDLTLRICQKHDIVGELTLFTEEPRYMLSAKVLEDGEV LVINKNKLEKELIQNGALTFEFMKWMSTHLRKIQSKIRDLLLHGKKGALYSTLIRLSN SYGVERSDGILINIVLTNQDLAKFCAAARESVNRMLGDLRKKGVISIDESGKIILHKR DYLRCEIECENCPLEICNID*" /label="fnr CDS" gene complement(3482627..3483343) /gene="fnr" /locus_tag="BSU_37310" /old_locus_tag="BSU37310" /label="fnr gene" downshifts complement(3482629) /Source="Nicolas_upshifts" /id="D1930" /incds=0 /nref=116 /ntot=238 /MaxReadThrough="3.06242" /MaxDrop="8.21489" /score="-2.80152808" /energy="-5.8" /TU="U2938,U2939" /idTUdmin="U2939" /TUdmin="-84" /isTUend="FALSE" /label="downshifts" downshifts complement(3482699) /Source="Nicolas_upshifts" /id="D1931" /incds=1 /nref=1 /ntot=1 /MaxReadThrough="8.51297" /MaxDrop="3.71248" /score="-2.80152808" /energy="-5.8" /TU="U2938,U2939" /idTUdmin="U2939" /TUdmin="-154" /isTUend="FALSE" /label="downshifts" misc_feature complement(3483369..3483388) /Source="Nicolas_upshift_promotors" /id="U2938" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.556443556443556" /psig="0.999000999001" /xcortree=1623 /SigmaFactorBS="cactggggcattcacaagattgttagttttttctcgatgggt acaaatcaattCACGTTACAATAAACACACAacgtgactttcttcgaggtgagctcat g" /listShort="fnr" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3483381) /Source="Nicolas_upshifts" /id="U2938" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.556443556443556" /psig="0.999000999001" /xcortree=1623 /SigmaFactorBS="cactggggcattcacaagattgttagttttttctcgatgggt acaaatcaattCACGTTACAATAAACACACAacgtgactttcttcgaggtgagctcat g" /listShort="fnr" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3483442..3484629) /gene="narK" /locus_tag="BSU_37320" /old_locus_tag="BSU37320" /function="16.8: Protect" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8682783, 8846791, 15849754, 16796679, 16850406, 26786044" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8682783, 8846791, 15849754, 16796679, 16850406, 26786044; Product type t : transporter" /codon_start=1 /transl_table=11 /product="nitrite extrusion permease" /protein_id="NP_391613.2" /db_xref="EnsemblGenomes-Gn:BSU37320" /db_xref="EnsemblGenomes-Tr:CAB15760" /db_xref="GOA:P46907" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11342" /db_xref="UniProtKB/Swiss-Prot:P46907" /translation="MINRQHIQLSLQSLSLVAGFMVWVLISSLISQITLDIHLSKGEI SLVTAIPVILGSLLRIPLGYLTNRFGARLMFMVSFILLLFPVFWISIADSLFDLIAGG FFLGIGGAVFSIGVTSLPKYYPKEKHGVVNGIYGAGNIGTAVTTFAAPVIAQAVGWKS TVQMYLILLAVFALLHVLFGDRHEKKVKVSVKTQIKAVYRNHVLWFLSLFYFITFGAF VAFTIYLPNFLVEHFGLNPADAGLRTAGFIAVSTLLRPAGGFLADKMSPLRILMFVFA GLTLSGIILSFSPTIGLYTFGSLTVAVCSGIGNGTVFKLVPFYFSKQAGIANGIVSAM GGLGGFFPPLILASVFQATGQYAIGFMALSEVALASFVLVIWMYWQERMKTHTERNSQ SIN*" /label="narK CDS" gene complement(3483442..3484629) /gene="narK" /locus_tag="BSU_37320" /old_locus_tag="BSU37320" /label="narK gene" misc_feature complement(3484659..3484678) /Source="Nicolas_upshift_promotors" /id="U2939" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.982017982017982" /psig="0.998001998001998" /xcortree=1615 /SigmaFactorBS="gctttgtcctttttttatgagaaaaacgtgtgatgtaattca caatcctgtttggctagTTTTTGTATGATAAGACTGAttattgaatcattgaaagggg c" /listShort="narK, fnr" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3484677) /Source="Nicolas_upshifts" /id="U2939" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.982017982017982" /psig="0.998001998001998" /xcortree=1615 /SigmaFactorBS="gctttgtcctttttttatgagaaaaacgtgtgatgtaattca caatcctgtttggctagTTTTTGTATGATAAGACTGAttattgaatcattgaaagggg c" /listShort="narK, fnr" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3484765..3486435) /gene="argS" /locus_tag="BSU_37330" /old_locus_tag="BSU37330" /EC_number="6.1.1.19" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:8289305, 9862121" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8289305, 9862121; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="arginyl-tRNA synthetase" /protein_id="NP_391614.1" /db_xref="EnsemblGenomes-Gn:BSU37330" /db_xref="EnsemblGenomes-Tr:CAB15761" /db_xref="GOA:P46906" /db_xref="InterPro:IPR001278" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR005148" /db_xref="InterPro:IPR008909" /db_xref="InterPro:IPR009080" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR035684" /db_xref="InterPro:IPR036695" /db_xref="SubtiList:BG11341" /db_xref="UniProtKB/Swiss-Prot:P46906" /translation="MNIAEQMKDVLKEEIKAAVLKAGLAEESQIPNVVLETPKDKTHG DYSTNMAMQLARVAKKAPRQIAEEIVAHFDKGKASIEKLDIAGPGFINFYMNNQYLTK LIPSVLEAGEAYGETNIGNGERVQVEFVSANPTGDLHLGHARGAAVGDSLCNVLSKAG YDVSREYYINDAGNQINNLALSVEVRYFEALGLEKPMPEDGYRGEDIIAIGKRLAEEY GDRFVNEEESERLAFFREYGLKYELEKLRKDLENFRVPFDVWYSETSLYQNGKIDKAL EALREKGHVYEEDGATWFRSTTFGDDKDRVLIKKDGTYTYLLPDIAYHKDKLDRGFDK LINVWGADHHGYIPRMKAAIEALGYEKGTLEVEIIQLVHLYKNGEKMKMSKRTGKAVT MRDLIEEVGLDAVRYFFAMRSADTHMDFDLDLAVSTSNENPVYYAQYAHARICSMLRQ GEEQGLKPAADLDFSHIQSEKEYDLLKTIGGFPEAVAEAAEKRIPHRVTNYIYDLASA LHSFYNAEKVIDPENEEKSRARLALMKATQITLNNALQLIGVSAPEKM*" /label="argS CDS" gene complement(3484765..3486435) /gene="argS" /locus_tag="BSU_37330" /old_locus_tag="BSU37330" /label="argS gene" downshifts complement(3484767) /Source="Nicolas_upshifts" /id="D1932" /incds=0 /nref=252 /ntot=266 /MaxReadThrough="1.71727" /MaxDrop="6.56513" /score="23.3947976" /energy="-12.5" /TU="NA" /idTUdmin="U2941" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3486432..3486860) /gene="ywiB" /locus_tag="BSU_37340" /old_locus_tag="BSU37340" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22333191; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="putative RNA binding protein" /protein_id="NP_391615.1" /db_xref="EnsemblGenomes-Gn:BSU37340" /db_xref="EnsemblGenomes-Tr:CAB15762" /db_xref="InterPro:IPR012674" /db_xref="InterPro:IPR015231" /db_xref="PDB:1R0U" /db_xref="SubtiList:BG14161" /db_xref="UniProtKB/Swiss-Prot:O07624" /translation="MKQETPITLHVKSVIEDDGNQEVIEFRTTGFYYVKQNKVYLSYY EEHDLGKVKTIVKVSEGEVLVMRSGAVKMNQRFVTGASTIAKYKMSFGELELKTSTKS IQSDLDEEKGRISIAYDMHVGDEQEHLHNMTITYEGGTHA*" /label="ywiB CDS" gene complement(3486432..3486860) /gene="ywiB" /locus_tag="BSU_37340" /old_locus_tag="BSU37340" /label="ywiB gene" misc_feature 3486928..3486942 /Source="Nicolas_upshift_promotors" /id="U2940" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.911088911088911" /psig="0.056943056943057" /xcortree=297 /SigmaFactorBS="ttcatcattccactttgacttgaatagtataatcattcggtt tgtaaacttcaACTGCTTCTATCTTAccatcattgctcatcagatttgaagataaacc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" promotor_-10 complement(3486928..3486947) /Source="Nicolas_upshift_promotors" /id="U2941" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.53946053946054" /psig=1 /xcortree=2566 /SigmaFactorBS="ctcttctatataaggaaatgctttttatgaggtttatCTTCa aatctgatgagcaatGATGGTAAGATAGAAGCAGTtgaagtttacaaaccgaatgatt a" /listShort="ywiB, argS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3486935 /Source="Nicolas_upshifts" /id="U2940" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.911088911088911" /psig="0.056943056943057" /xcortree=297 /SigmaFactorBS="ttcatcattccactttgacttgaatagtataatcattcggtt tgtaaacttcaACTGCTTCTATCTTAccatcattgctcatcagatttgaagataaacc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(3486944) /Source="Nicolas_upshifts" /id="U2941" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.53946053946054" /psig=1 /xcortree=2566 /SigmaFactorBS="ctcttctatataaggaaatgctttttatgaggtttatCTTCa aatctgatgagcaatGATGGTAAGATAGAAGCAGTtgaagtttacaaaccgaatgatt a" /listShort="ywiB, argS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3486964..3486967) /Source="Nicolas_upshift_promotors" /id="U2941" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.53946053946054" /psig=1 /xcortree=2566 /SigmaFactorBS="ctcttctatataaggaaatgctttttatgaggtttatCTTCa aatctgatgagcaatGATGGTAAGATAGAAGCAGTtgaagtttacaaaccgaatgatt a" /listShort="ywiB, argS" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature complement(3486999..3487018) /Source="Nicolas_upshift_promotors" /id="U2942" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.802197802197802" /psig="0.932067932067932" /xcortree=1621 /SigmaFactorBS="gtgaaaaggaaatgatagatttcggaaaaatgtaacatttcc taaaggtaattAGTGATATGATTTTCTCTTCtatataaggaaatgctttttatgaggt t" /GFF_Attribute="listShort" /listLong="ywiB, argS" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3487011) /Source="Nicolas_upshifts" /id="U2942" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.802197802197802" /psig="0.932067932067932" /xcortree=1621 /SigmaFactorBS="gtgaaaaggaaatgatagatttcggaaaaatgtaacatttcc taaaggtaattAGTGATATGATTTTCTCTTCtatataaggaaatgctttttatgaggt t" /GFF_Attribute="listShort" /listLong="ywiB, argS" /label="upshifts" promotor_-35 3487091..3487098 /Source="Nicolas_upshift_promotors" /id="U2943" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=1610 /SigmaFactorBS="tccgaaatctatcatttccttttcacatttttttcaaaatat atgTATTGAATtagtaatttgatAGTTTTAAGATAAAAGTACAacatagatctgctag a" /listShort="sboA, sboX, albA, albB, albC, albD, albE, albF, albG, S1450" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3487106 /Source="Nicolas_upshifts" /id="U2943" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=1610 /SigmaFactorBS="tccgaaatctatcatttccttttcacatttttttcaaaatat atgTATTGAATtagtaatttgatAGTTTTAAGATAAAAGTACAacatagatctgctag a" /listShort="sboA, sboX, albA, albB, albC, albD, albE, albF, albG, S1450" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3487111..3487130 /Source="Nicolas_upshift_promotors" /id="U2943" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=1610 /SigmaFactorBS="tccgaaatctatcatttccttttcacatttttttcaaaatat atgTATTGAATtagtaatttgatAGTTTTAAGATAAAAGTACAacatagatctgctag a" /listShort="sboA, sboX, albA, albB, albC, albD, albE, albF, albG, S1450" /GFF_Attribute="listLong" /label="promotor_-10" downshifts 3487155 /Source="Nicolas_upshifts" /id="D1933" /incds=0 /nref=1 /ntot=3 /MaxReadThrough="8.77621" /MaxDrop="1.77243" /score="6.03938699" /energy="-13.2" /TU="U2943" /idTUdmin="U2937" /TUdmin=4576 /isTUend="FALSE" /label="downshifts" CDS 3487173..3487304 /gene="sboA" /locus_tag="BSU_37350" /old_locus_tag="BSU37350" /function="16.8: Protect" /function="16.4: Excrete" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:12696888, 15743949, 16095584, 17213266, 27914001" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12696888, 15743949, 16095584, 17213266, 27914001; Product type f: factor" /codon_start=1 /transl_table=11 /product="subtilosin A" /protein_id="NP_391616.1" /db_xref="EnsemblGenomes-Gn:BSU37350" /db_xref="EnsemblGenomes-Tr:CAB15763" /db_xref="GOA:O07623" /db_xref="InterPro:IPR021539" /db_xref="PDB:1PXQ" /db_xref="SubtiList:BG12671" /db_xref="UniProtKB/Swiss-Prot:O07623" /translation="MKKAVIVENKGCATCSIGAACLVDGPIPDFEIAGATGLFGLWG* " /label="sboA CDS" gene 3487173..3487304 /gene="sboA" /locus_tag="BSU_37350" /old_locus_tag="BSU37350" /label="sboA gene" CDS 3487261..3487413 /gene="sboX" /locus_tag="BSU_37360" /old_locus_tag="BSU37360" /function="16.5: Explore" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15743949; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative bacteriocin-like product" /protein_id="YP_054594.1" /db_xref="EnsemblGenomes-Gn:BSU37360" /db_xref="EnsemblGenomes-Tr:CAE01468" /db_xref="SubtiList:BG14182" /db_xref="UniProtKB/Swiss-Prot:Q7WY57" /translation="MKLPVQQVYSVYGGKDLPKGHSHSTMPFLSKLQFLTKIYLLDIH TQPFFI*" /label="sboX CDS" gene 3487261..3487413 /gene="sboX" /locus_tag="BSU_37360" /old_locus_tag="BSU37360" /label="sboX gene" downshifts 3487293 /Source="Nicolas_upshifts" /id="D1934" /incds=0 /nref=4 /ntot=32 /MaxReadThrough="8.85351" /MaxDrop="5.1396" /score="6.03938699" /energy="-13.2" /TU="U2943" /idTUdmin="U2937" /TUdmin=4714 /isTUend="FALSE" /label="downshifts" promotor_-35 3487408..3487414 /Source="Nicolas_upshift_promotors" /id="U2944" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.482517482517482" /psig="0.99000999000999" /xcortree=3233 /SigmaFactorBS="atctacctcttggatatacatacacaaccgtttttcATTTGA AtcatatgtatagggGATGGTATTTTGTTTATAGAgcagatgtttccatttattaatg a" /listShort="albA, albB, albC, albD, albE, albF, albG, S1450" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3487429..3487448 /Source="Nicolas_upshift_promotors" /id="U2944" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.482517482517482" /psig="0.99000999000999" /xcortree=3233 /SigmaFactorBS="atctacctcttggatatacatacacaaccgtttttcATTTGA AtcatatgtatagggGATGGTATTTTGTTTATAGAgcagatgtttccatttattaatg a" /listShort="albA, albB, albC, albD, albE, albF, albG, S1450" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3487432 /Source="Nicolas_upshifts" /id="U2944" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.482517482517482" /psig="0.99000999000999" /xcortree=3233 /SigmaFactorBS="atctacctcttggatatacatacacaaccgtttttcATTTGA AtcatatgtatagggGATGGTATTTTGTTTATAGAgcagatgtttccatttattaatg a" /listShort="albA, albB, albC, albD, albE, albF, albG, S1450" /GFF_Attribute="listLong" /label="upshifts" CDS 3487438..3488784 /gene="albA" /locus_tag="BSU_37370" /old_locus_tag="BSU37370" /EC_number="1.21.98.-" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:15066831, 15743949, 22366720" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15066831, 15743949, 22366720; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="subtilosin A thioether formation enzyme" /protein_id="NP_391617.1" /db_xref="EnsemblGenomes-Gn:BSU37370" /db_xref="EnsemblGenomes-Tr:CAB15764" /db_xref="GOA:P71011" /db_xref="InterPro:IPR006638" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR008792" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR017200" /db_xref="InterPro:IPR023885" /db_xref="InterPro:IPR034395" /db_xref="InterPro:IPR034481" /db_xref="SubtiList:BG12471" /db_xref="UniProtKB/Swiss-Prot:P71011" /translation="MFIEQMFPFINESVRVHQLPEGGVLEIDYLRDNVSISDFEYLDL NKTAYELCMRMDGQKTAEQILAEQCAVYDESPEDHKDWYYDMLNMLQNKQVIQLGNRA SRHTITTSGSNEFPMPLHATFELTHRCNLKCAHCYLESSPEALGTVSIEQFKKTADML FDNGVLTCEITGGEIFVHPNANEILDYVCKKFKKVAVLTNGTLMRKESLELLKTYKQK IIVGISLDSVNSEVHDSFRGRKGSFAQTCKTIKLLSDHGIFVRVAMSVFEKNMWEIHD MAQKVRDLGAKAFSYNWVDDFGRGRDIVHPTKDAEQHRKFMEYEQHVIDEFKDLIPII PYERKRAANCGAGWKSIVISPFGEVRPCALFPKEFSLGNIFHDSYESIFNSPLVHKLW QAQAPRFSEHCMKDKCPFSGYCGGCYLKGLNSNKYHRKNICSWAKNEQLEDVVQLI*" /label="albA CDS" gene 3487438..3488784 /gene="albA" /locus_tag="BSU_37370" /old_locus_tag="BSU37370" /label="albA gene" CDS 3488797..3488958 /gene="albB" /locus_tag="BSU_37380" /old_locus_tag="BSU37380" /function="16.4: Excrete" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10809709, 15743949" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10809709, 15743949; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="membrane component involved in subtilosin production" /protein_id="NP_391618.1" /db_xref="EnsemblGenomes-Gn:BSU37380" /db_xref="EnsemblGenomes-Tr:CAB15765" /db_xref="GOA:P71010" /db_xref="SubtiList:BG12470" /db_xref="UniProtKB/Swiss-Prot:P71010" /translation="MSPAQRRILLYILSFIFVIGAVVYFVKSDYLFTLIFIAIAILFG MRARKADSR*" /label="albB CDS" gene 3488797..3488958 /gene="albB" /locus_tag="BSU_37380" /old_locus_tag="BSU37380" /label="albB gene" CDS 3488955..3489674 /gene="albC" /locus_tag="BSU_37390" /old_locus_tag="BSU37390" /function="16.5: Explore" /function="16.6: Maintain" /function="16.4: Excrete" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10809709, 15066831, 15743949; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter involved in subtilosin production" /protein_id="NP_391619.1" /db_xref="EnsemblGenomes-Gn:BSU37390" /db_xref="EnsemblGenomes-Tr:CAB15766" /db_xref="GOA:P71009" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12469" /db_xref="UniProtKB/Swiss-Prot:P71009" /translation="MSILDIHDVSVWYERDNVILEQVDLHLEKGAVYGLLGVNGAGKT TLINTLTGVNRNFSGRFTLCGIEAEAGMPQKTSDQLKTHRYFAADYPLLFTEITAKDY VSFVHSLYQKDFSEQQFASLAEAFHFSKYINRRISELSLGNRQKVVLMTGLLLRAPLF ILDEPLVGLDVESIEVFYQKMREYCEAGGTILFSSHLLDVVQRFCDYAAILHNKQIQK VIPIGEETDLRREFFEVIGHE*" /label="albC CDS" gene 3488955..3489674 /gene="albC" /locus_tag="BSU_37390" /old_locus_tag="BSU37390" /label="albC gene" CDS 3489667..3490977 /gene="albD" /locus_tag="BSU_37400" /old_locus_tag="BSU37400" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 10809709, 15066831, 15743949, 15849754, 16850406, 18034824; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="integral membrane protein involved in subtilosinproduction and immunity" /protein_id="NP_391620.1" /db_xref="EnsemblGenomes-Gn:BSU37400" /db_xref="EnsemblGenomes-Tr:CAB15767" /db_xref="GOA:P71008" /db_xref="SubtiList:BG12468" /db_xref="UniProtKB/Swiss-Prot:P71008" /translation="MNNIIPIMSLLFKQLYSRQGKKDAIRIAAGLVILAVFEIGLIRQ AGIDESVLRKTYIILALLLMNTYMVFLSVTSQWKESYMKLSCLLPISSRSFWLAQSVV LFVDTCLRRTLFFFILPLFLFGNGTLSGAQTLFWLGRFSFFTVYSIIFGVVLSNHFVK KKNLMFLLHAAIFACVCISAALMPAATIPLCAVHILWAVVIDFPVFLQAPPQQGKMHS FMRRSEFSFYKREWNRFISSKAMLLNYAVMAVFSGFFSFQMMNTGIFNQQVIYIVISA LLLICSPIALLYSIEKNDRMLLITLPIKRKTMFWAKYRFYSGLLAGGFLLVVMIVGFI SGRSISVLTFLQCIELLLAGAYIRLTADEKRPSFSWQTEQQLWSGFSKYRSYLFCLPL FLAILAGTAVSLAVIPIAGLVIVYYLQKQDGGFFDTSKRERLGS*" /label="albD CDS" gene 3489667..3490977 /gene="albD" /locus_tag="BSU_37400" /old_locus_tag="BSU37400" /label="albD gene" CDS 3490967..3492127 /gene="albE" /locus_tag="BSU_37410" /old_locus_tag="BSU37410" /function="16.8: Protect" /function="16.5: Explore" /function="16.4: Excrete" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 10809709, 15066831, 15743949; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peptidase involved in subtilosin A production" /protein_id="NP_391621.1" /db_xref="EnsemblGenomes-Gn:BSU37410" /db_xref="EnsemblGenomes-Tr:CAB15768" /db_xref="GOA:P71007" /db_xref="InterPro:IPR007863" /db_xref="InterPro:IPR011249" /db_xref="SubtiList:BG12467" /db_xref="UniProtKB/Swiss-Prot:P71007" /translation="MEVNLLKTHQFSTISIAASFLKPIESAAEPEEETIYFYGAAAYL KEQIIDAFGYAAGSRFMYSANLFFDQQLKTCGTRLIHPLYNGNLHVDALMKTFADLSF PSSLSFEAFEKARNELLLKIEKKFTDPFSYSAARLAEEVFGNPMYGTGMFGRRDRIKA IHPKRFLDATDFIVDLVSQQKQLNILGQVQACDVRGHAPQTSAVTSGRIPVNRHVFET ETRSAAGPSVLTLGFDCGEMKDASDYIKIQLIDGLLGKYGHSALFKHFREKDLAVYHV ITRYDVMNNLLLVSICTDQLHEKDIPPRVLEAVSAFHTDERELEQAKQFLRNELLLQF DSPEGLLAYMGVLRRFSCTKEALLDGISAVTCRDVLQFIATINYIGAHVVRG*" /label="albE CDS" gene 3490967..3492127 /gene="albE" /locus_tag="BSU_37410" /old_locus_tag="BSU37410" /label="albE gene" CDS 3492132..3493412 /gene="albF" /locus_tag="BSU_37420" /old_locus_tag="BSU37420" /EC_number="3.4.24.-" /function="16.8: Protect" /function="16.4: Excrete" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10809709, 15066831, 15743949, 25817994; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative peptidase involved in subtilosin production" /protein_id="NP_391622.1" /db_xref="EnsemblGenomes-Gn:BSU37420" /db_xref="EnsemblGenomes-Tr:CAB15769" /db_xref="GOA:P71006" /db_xref="InterPro:IPR011249" /db_xref="InterPro:IPR011765" /db_xref="SubtiList:BG12466" /db_xref="UniProtKB/Swiss-Prot:P71006" /translation="MEKKAFFQQLDERTDIRYTDSGLKIFRLKFPRAHLRLCNVKIDF GSRDVCIRAESGDTLLPYGTAHFLEHLLFWHNGRNLYSDFFAHGALLNAFTTYTDTNF MFTSLPDRLRQTIPILLDALWNHSFDKKIVAQEKAVITSEIQTAHLNHQLSYHYQLIS MLSPSSPAAVFPAGRIEDIEALDISDLQKAYKAAYQAHRMTLFLIGGSENTETLLPPH LQLEKRPDYHAERKIIPACPPVLSQKMMLGDEERMEDTWTGLQIGALPGQNDLLSIKL YWDIAARILFQLDSPFFQEIQQTYRLEIDRLSAETYIYEDGGFLILHSQGTHSSAYID VASYYVTQKKEQVAAWLQYGKDSLTDAIIYDSDYVRKCFEWAAECDRCDCSFLDMYHI IQDMDAQVFLSLIDAMASSNKAIIHVSQKEAIRQ*" /label="albF CDS" gene 3492132..3493412 /gene="albF" /locus_tag="BSU_37420" /old_locus_tag="BSU37420" /label="albF gene" CDS 3493409..3494110 /gene="albG" /locus_tag="BSU_37430" /old_locus_tag="BSU37430" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10809709, 15066831, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein involved in subtilosin production and immunity" /protein_id="NP_391623.1" /db_xref="EnsemblGenomes-Gn:BSU37430" /db_xref="EnsemblGenomes-Tr:CAB15770" /db_xref="GOA:P71005" /db_xref="SubtiList:BG12465" /db_xref="UniProtKB/Swiss-Prot:P71005" /translation="MKQSTVFTLLLLLIGMAAYSFGWVQAVAEAAAQYVQMINNDAVR LGLLACTAALLMLPAFLYLHYVTQSVKNMTAAFQKLTQSHQSCCDFQQHNLCSRYAED VKSLRDSYKNVRQTYVMAAVLCQVIIFGCMFEIVKAVPFRLHTPPAFSMGLAMLLILY LLFCMRTYLRQLFRHGSLFRKVFAGALAAAGIWWMLSFSISELLFLIILAAIQQIGSF IYKRFSYHSTASLDL*" /label="albG CDS" gene 3493409..3494110 /gene="albG" /locus_tag="BSU_37430" /old_locus_tag="BSU37430" /label="albG gene" downshifts complement(3493677) /Source="Nicolas_upshifts" /id="D1935" /incds=1 /nref=2 /ntot=5 /MaxReadThrough="0.362109999999999" /MaxDrop="3.55474" /score="6.50386958" /energy="-12" /TU="NA" /idTUdmin="U2945" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(3493766..3494115) /Source="Nicolas_S_feature" /locus_tag="new_3842651_3843000_c" /HighExp="BT, B36, B60, Pyr, G/S, Mal, S3, G135, M/G, Sw" /AntisenseName="albG" /AntisenseCor="2.0087959212361201E-2" /AntisenseRegPval="-0.1" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1449" downshifts complement(3493809) /Source="Nicolas_upshifts" /id="D1936" /incds=1 /nref=6 /ntot=18 /MaxReadThrough="3.01883" /MaxDrop="4.2137" /score="6.50386958" /energy="-12" /TU="U2945" /idTUdmin="U2945" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" S_feature 3494111..3496593 /Source="Nicolas_S_feature" /locus_tag="new_3842996_3845478" /HighExp="Lbstat, nit, ferm, BI, M0t90, S2, M40t90, BT, M0t45, GM 150" /AntisenseName="ywhL" /AntisenseCor="7.7827453562424306E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.99, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1450" CDS complement(3494116..3495492) /gene="ywhL" /locus_tag="BSU_37440" /old_locus_tag="BSU37440" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12073041" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391624.1" /db_xref="EnsemblGenomes-Gn:BSU37440" /db_xref="EnsemblGenomes-Tr:CAB15771" /db_xref="InterPro:IPR011045" /db_xref="InterPro:IPR015943" /db_xref="SubtiList:BG12464" /db_xref="UniProtKB/Swiss-Prot:P71004" /translation="MKKNDLSALQENCFCFCDEEISREAPFQVPIDFPEGFKVDTAEA SAAVTWSTDNLSCISEPCLIQTGPEPEDIGVRYAVRVQGTITLLVSVSPVRNQYGQGD GAVSVIHTEEIDQVVYYAAQSGRCPDFSQITVEDLLIVPPFYGSPLTVAGTLVLPPSP DPQSYVFTANTGDSTVSVIDADLNTVVKTIPFSDVPTNLGVTFDKAFTYVLHGNTNLV SVIDNKTLTIINTITVGGGPRKIEFDPTDEFAYVMAAGSIYVINTASQSVIDVIPIPG ALDFALDPNGQYVYTANGSSWSVDKYDVNTGQLVESIIDTFEFPSLITTPYAGNFAYV LNGELWPKGVTEISLSPLSRGGDFSRLFETLRTIVFSLDSTRAYFLEPYSEPFLINNL YVVNTARQRIIANVSLPGAFDLAVTPDKQYIYAAQPNDNAVTVYRTSDYTAVTVIPVG AGPSAIAM*" /label="ywhL CDS" gene complement(3494116..3495492) /gene="ywhL" /locus_tag="BSU_37440" /old_locus_tag="BSU37440" /label="ywhL gene" CDS complement(3495531..3496886) /gene="ywhK" /locus_tag="BSU_37450" /old_locus_tag="BSU37450" /function="16.6: Maintain" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:12073041" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12073041; Product type f: factor" /codon_start=1 /transl_table=11 /product="factor interacting with DNA helicase PcrA" /protein_id="NP_391625.1" /db_xref="EnsemblGenomes-Gn:BSU37450" /db_xref="EnsemblGenomes-Tr:CAB15772" /db_xref="InterPro:IPR011045" /db_xref="InterPro:IPR015943" /db_xref="SubtiList:BG12463" /db_xref="UniProtKB/Swiss-Prot:P71003" /translation="MRKNKLSFKEKAGAEQEECLCFCEGEASREAMFQAPIELPEGFV VDPAEAVANVTWNADSLSCVSDRCLIQTGPEPDEVGVQFAVRLQGTVTLLVSVSPVRN QYGQGDGAVSVIHNAEIDQVVYYSDESDDCPDISDITIENLVVVPPFYGSPLSVTGTI VLVPEPEPVYAFTANPNDQSVSVIDTNTDTVVTTIALPYNPAGIEITPDKSAVFVLHP NNNVISVIDYDTLTVTATILLDQPPRLIRFIPNHEFAYVFTGTAVYVIGIDTLTVDRS IPVEGYDVAIDPNGLFAYVLNFGIVQKVDLTTGEVTGTIERELIVSTIETNWPERYAY VLEQEFFFNYLTVIDLNTFTISSTQELEYEGEYRMFTSGAEVYLYDGFTGNLYSVSPN GAGVIGNVPQSATDYAFTPNGDFLYATRFIEQSIIVYNTDDYSEETVISLGVSPGAIT I*" /label="ywhK CDS" gene complement(3495531..3496886) /gene="ywhK" /locus_tag="BSU_37450" /old_locus_tag="BSU37450" /label="ywhK gene" promotor_-10 complement(3496922..3496941) /Source="Nicolas_upshift_promotors" /id="U2945" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1430 /SigmaFactorBS="tatattttcaaaaagaagcgtttaccctcagcaatttGTACA AGCAAacacgttaccctTCCATATTCTGTTATATCTGcgtgagcagtgtatgtctgaa a" /listShort="ywhK, ywhL, S1449" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3496940) /Source="Nicolas_upshifts" /id="U2945" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1430 /SigmaFactorBS="tatattttcaaaaagaagcgtttaccctcagcaatttGTACA AGCAAacacgttaccctTCCATATTCTGTTATATCTGcgtgagcagtgtatgtctgaa a" /listShort="ywhK, ywhL, S1449" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3496954..3496963) /Source="Nicolas_upshift_promotors" /id="U2945" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1430 /SigmaFactorBS="tatattttcaaaaagaagcgtttaccctcagcaatttGTACA AGCAAacacgttaccctTCCATATTCTGTTATATCTGcgtgagcagtgtatgtctgaa a" /listShort="ywhK, ywhL, S1449" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 3497066..3497085 /Source="Nicolas_upshift_promotors" /id="U2946" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.899100899100899" /psig="0.921078921078921" /xcortree=683 /SigmaFactorBS="aacatgcggtgtaacgaaagaaaaaattgcggtttttttgcg cttctcacaagaatgttGATGATAAAATATGACATATatagaattatgaagggaggga t" /listShort="rapF, phrF, S1451, ywhH" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3497067 /Source="Nicolas_upshifts" /id="U2946" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.899100899100899" /psig="0.921078921078921" /xcortree=683 /SigmaFactorBS="aacatgcggtgtaacgaaagaaaaaattgcggtttttttgcg cttctcacaagaatgttGATGATAAAATATGACATATatagaattatgaagggaggga t" /listShort="rapF, phrF, S1451, ywhH" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(3497112) /Source="Nicolas_upshifts" /id="D1937" /incds=0 /nref=7 /ntot=59 /MaxReadThrough="2.35357" /MaxDrop="4.85842" /score="29.5788849" /energy="-11.3" /TU="NA" /idTUdmin="U2948" /TUdmin=1867 /isTUend="FALSE" /label="downshifts" CDS 3497116..3498261 /gene="rapF" /locus_tag="BSU_37460" /old_locus_tag="BSU37460" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15968044, 16816200, 23526880" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15968044, 16816200, 23526880; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="response regulator aspartate phosphatase anti-activator of ComA" /protein_id="NP_391626.1" /db_xref="EnsemblGenomes-Gn:BSU37460" /db_xref="EnsemblGenomes-Tr:CAB15773" /db_xref="GOA:P71002" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="PDB:3ULQ" /db_xref="PDB:4I9C" /db_xref="PDB:4I9E" /db_xref="SubtiList:BG11968" /db_xref="UniProtKB/Swiss-Prot:P71002" /translation="MTGVISSSSIGEKINEWYMYIRRFSIPDAEYLRREIKQELDQME EDQDLHLYYSLMEFRHNLMLEYLEPLEKMRIEEQPRLSDLLLEIDKKQARLTGLLEYY FNFFRGMYELDQREYLSAIKFFKKAESKLIFVKDRIEKAEFFFKMSESYYYMKQTYFS MDYARQAYEIYKEHEAYNIRLLQCHSLFATNFLDLKQYEDAISHFQKAYSMAEAEKQP QLMGRTLYNIGLCKNSQSQYEDAIPYFKRAIAVFEESNILPSLPQAYFLITQIHYKLG KIDKAHEYHSKGMAYSQKAGDVIYLSEFEFLKSLYLSGPDEEAIQGFFDFLESKMLYA DLEDFAIDVAKYYHERKNFQKASAYFLKVEQVRQLIQGGVSLYEIEV*" /label="rapF CDS" gene 3497116..3498261 /gene="rapF" /locus_tag="BSU_37460" /old_locus_tag="BSU37460" /label="rapF gene" promotor_-35 3498120..3498124 /Source="Nicolas_upshift_promotors" /id="U2947" /multdbtbs="SigH" /comp="M16" /sig="SigA" /pcomp="0.585414585414585" /psig="0.986013986013986" /xcortree=751 /SigmaFactorBS="gattttctcgaaagtaaaatgttgtatgctgaTCTTGaagat ttcgctattgaTGTGGCAAAATATTATCATGaacgtaaaaattttcaaaaagcttctg c" /listShort="phrF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3498141..3498160 /Source="Nicolas_upshift_promotors" /id="U2947" /multdbtbs="SigH" /comp="M16" /sig="SigA" /pcomp="0.585414585414585" /psig="0.986013986013986" /xcortree=751 /SigmaFactorBS="gattttctcgaaagtaaaatgttgtatgctgaTCTTGaagat ttcgctattgaTGTGGCAAAATATTATCATGaacgtaaaaattttcaaaaagcttctg c" /listShort="phrF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3498148 /Source="Nicolas_upshifts" /id="U2947" /multdbtbs="SigH" /comp="M16" /sig="SigA" /pcomp="0.585414585414585" /psig="0.986013986013986" /xcortree=751 /SigmaFactorBS="gattttctcgaaagtaaaatgttgtatgctgaTCTTGaagat ttcgctattgaTGTGGCAAAATATTATCATGaacgtaaaaattttcaaaaagcttctg c" /listShort="phrF" /GFF_Attribute="listLong" /label="upshifts" downshifts complement(3498231) /Source="Nicolas_upshifts" /id="D1938" /incds=0 /nref=1 /ntot=59 /MaxReadThrough="1.70728" /MaxDrop="2.74755" /score="29.5788849" /energy="-11.3" /TU="NA" /idTUdmin="U2948" /TUdmin=748 /isTUend="FALSE" /label="downshifts" CDS 3498245..3498364 /gene="phrF" /locus_tag="BSU_37470" /old_locus_tag="BSU37470" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15968044, 16816200, 23526880" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15968044, 16816200, 23526880; Product type f: factor" /codon_start=1 /transl_table=11 /product="secreted regulator of the activity of phosphatase RapF" /protein_id="NP_391627.1" /db_xref="EnsemblGenomes-Gn:BSU37470" /db_xref="EnsemblGenomes-Tr:CAB15774" /db_xref="GOA:P71001" /db_xref="InterPro:IPR025899" /db_xref="SubtiList:BG11960" /db_xref="UniProtKB/Swiss-Prot:P71001" /translation="MKLKSKLLLSCLALSTVFVATTIANAPTHQIEVAQRGMI*" /label="phrF CDS" gene 3498245..3498364 /gene="phrF" /locus_tag="BSU_37470" /old_locus_tag="BSU37470" /label="phrF gene" downshifts 3498349 /Source="Nicolas_upshifts" /id="D1939" /incds=0 /nref=240 /ntot=268 /MaxReadThrough="5.48985" /MaxDrop="6.14096" /score="19.6493244" /energy="-9.9" /TU="U2946" /idTUdmin="U2947" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" S_feature 3498394..3498462 /Source="Nicolas_S_feature" /locus_tag="new_3847279_3847347" /HighExp="S2, S3, S4, S5, S6, S1, BT, S7, S8, Fru" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.921" /TUlongSig="NA" /TUlongPSig="NA" /label="S1451" CDS 3498463..3498936 /gene="ywhH" /locus_tag="BSU_37480" /old_locus_tag="BSU37480" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative tRNA editing enzyme" /protein_id="NP_391628.1" /db_xref="EnsemblGenomes-Gn:BSU37480" /db_xref="EnsemblGenomes-Tr:CAB15775" /db_xref="GOA:P71000" /db_xref="InterPro:IPR007214" /db_xref="InterPro:IPR036754" /db_xref="SubtiList:BG12462" /db_xref="UniProtKB/Swiss-Prot:P71000" /translation="MSLKSVRTHFTQWNRENDVTEFETSSATVEQAAETIGVSLSRIA KSLSFRGEGDQVILIVAAGDAKIDNKKSRQTFGFKARMLSPNEVLEQTGHEIGGVCPF GLAHDPEVYLDVSLKRFQTVFPACGSRNSAIELTPKELSEFSFSKVWIDVCKDWE*" /label="ywhH CDS" gene 3498463..3498936 /gene="ywhH" /locus_tag="BSU_37480" /old_locus_tag="BSU37480" /label="ywhH gene" downshifts 3498925 /Source="Nicolas_upshifts" /id="D1940" /incds=0 /nref=30 /ntot=156 /MaxReadThrough="2.85314" /MaxDrop="4.40065" /score="-6.80415499" /energy="-11.3" /TU="NA" /idTUdmin="U2946" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3498968..3499840) /gene="speB" /locus_tag="BSU_37490" /old_locus_tag="BSU37490" /EC_number="3.5.3.11" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9723923, 10931887, 24678831, 28807600, 28291380" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9723923, 10931887, 24678831, 28807600, 28291380; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="agmatinase" /protein_id="NP_391629.1" /db_xref="EnsemblGenomes-Gn:BSU37490" /db_xref="EnsemblGenomes-Tr:CAB15776" /db_xref="GOA:P70999" /db_xref="InterPro:IPR005925" /db_xref="InterPro:IPR006035" /db_xref="InterPro:IPR020855" /db_xref="InterPro:IPR023696" /db_xref="SubtiList:BG12461" /db_xref="UniProtKB/Swiss-Prot:P70999" /translation="MRFDEAYSGKVFIASRPEWEEADAILYGMPMDWTVSYRPGSRFG PSRIREVSIGLEEYSPYLDRDLADLNFFDAGDIPLPFGNPQRSLDMIEEYVDSILEKG KFPMGMGGEHLVSWPVIKAMYKKYPDLAIIHFDAHTDLRVDYEGEPLSHSTPIRKAAE LIGPHNVYSFGIRSGMKEEFEWAKENGMHISKFEVLEPLKEVLPKLAGRPVYVTIDID VLDPAHAPGTGTVDAGGITSKELLASVHEIARSEVNVKGADLVEVAPVYDHSEQTANT ASKIIREMLLGFVK*" /label="speB CDS" gene complement(3498968..3499840) /gene="speB" /locus_tag="BSU_37490" /old_locus_tag="BSU37490" /label="speB gene" downshifts complement(3498979) /Source="Nicolas_upshifts" /id="D1941" /incds=0 /nref=49 /ntot=171 /MaxReadThrough="2.5482" /MaxDrop="5.46925" /score="29.5788849" /energy="-11.3" /TU="NA" /idTUdmin="U2948" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(3499045) /Source="Nicolas_upshifts" /id="D1942" /incds=1 /nref=8 /ntot=50 /MaxReadThrough="5.83631" /MaxDrop="3.87062" /score="29.5788849" /energy="-11.3" /TU="U2948" /idTUdmin="U2948" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" CDS complement(3499901..3500731) /gene="speE" /locus_tag="BSU_37500" /old_locus_tag="BSU37500" /EC_number="2.5.1.16" /function="16.3: Control" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9723923, 26735940, 28546427, 28807600" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9723923, 26735940, 28546427, 28807600; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spermidine synthase; polyamine metabolism" /protein_id="NP_391630.1" /db_xref="EnsemblGenomes-Gn:BSU37500" /db_xref="EnsemblGenomes-Tr:CAB15777" /db_xref="GOA:P70998" /db_xref="InterPro:IPR001045" /db_xref="InterPro:IPR029063" /db_xref="InterPro:IPR030373" /db_xref="InterPro:IPR030374" /db_xref="InterPro:IPR035246" /db_xref="InterPro:IPR037163" /db_xref="PDB:1IY9" /db_xref="SubtiList:BG12460" /db_xref="UniProtKB/Swiss-Prot:P70998" /translation="MSELWYTEKQTKNFGITMKVNKTLHTEQTEFQHLEMVETEEFGN MLFLDGMVMTSEKDEFVYHEMVAHVPLFTHPNPEHVLVVGGGDGGVIREILKHPSVKK ATLVDIDGKVIEYSKKFLPSIAGKLDDPRVDVQVDDGFMHIAKSENQYDVIMVDSTEP VGPAVNLFTKGFYAGIAKALKEDGIFVAQTDNPWFTPELITNVQRDVKEIFPITKLYT ANIPTYPSGLWTFTIGSKKYDPLAVEDSRFFDIETKYYTKDIHKAAFVLPKFVSDLIK *" /label="speE CDS" gene complement(3499901..3500731) /gene="speE" /locus_tag="BSU_37500" /old_locus_tag="BSU37500" /label="speE gene" S_feature complement(3500732..3500827) /Source="Nicolas_S_feature" /locus_tag="new_3849617_3849712_c" /HighExp="Paraq, G180, Oxctl, H2O2, LBGexp, G150, G135, C30, dia15, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S1452" promotor_-10 complement(3500815..3500834) /Source="Nicolas_upshift_promotors" /id="U2948" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.523476523476524" /psig="0.988011988011988" /xcortree=2546 /SigmaFactorBS="gatcgtttttaaacatcgcagaacaggacgcaTCTTTACTtt ttccccgccaTCCTCTATACTTTTTCCTTAggtgaaaatgagatttcaaccgagaata a" /listShort="S1452, speE, speB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3500826) /Source="Nicolas_upshifts" /id="U2948" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.523476523476524" /psig="0.988011988011988" /xcortree=2546 /SigmaFactorBS="gatcgtttttaaacatcgcagaacaggacgcaTCTTTACTtt ttccccgccaTCCTCTATACTTTTTCCTTAggtgaaaatgagatttcaaccgagaata a" /listShort="S1452, speE, speB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3500847..3500854) /Source="Nicolas_upshift_promotors" /id="U2948" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.523476523476524" /psig="0.988011988011988" /xcortree=2546 /SigmaFactorBS="gatcgtttttaaacatcgcagaacaggacgcaTCTTTACTtt ttccccgccaTCCTCTATACTTTTTCCTTAggtgaaaatgagatttcaaccgagaata a" /listShort="S1452, speE, speB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3500872..3500877 /Source="Nicolas_upshift_promotors" /id="U2949" /multdbtbs="SigF,SigG" /comp="M3" /sig="SigEF" /pcomp="0.758241758241758" /psig="0.758241758241758" /xcortree=1076 /SigmaFactorBS="tggcggggaaaaagtaaagatgcgtcctgttctgcgaTGTTT AaaaacgatcttttttTCTCATAATAGTAGAAACAtaaaaaaagggggaacccgttgt g" /listShort="pbpG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3500893..3500911 /Source="Nicolas_upshift_promotors" /id="U2949" /multdbtbs="SigF,SigG" /comp="M3" /sig="SigEF" /pcomp="0.758241758241758" /psig="0.758241758241758" /xcortree=1076 /SigmaFactorBS="tggcggggaaaaagtaaagatgcgtcctgttctgcgaTGTTT AaaaacgatcttttttTCTCATAATAGTAGAAACAtaaaaaaagggggaacccgttgt g" /listShort="pbpG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3500895 /Source="Nicolas_upshifts" /id="U2949" /multdbtbs="SigF,SigG" /comp="M3" /sig="SigEF" /pcomp="0.758241758241758" /psig="0.758241758241758" /xcortree=1076 /SigmaFactorBS="tggcggggaaaaagtaaagatgcgtcctgttctgcgaTGTTT AaaaacgatcttttttTCTCATAATAGTAGAAACAtaaaaaaagggggaacccgttgt g" /listShort="pbpG" /GFF_Attribute="listLong" /label="upshifts" CDS 3500933..3503008 /gene="pbpG" /locus_tag="BSU_37510" /old_locus_tag="BSU37510" /function="16.5: Explore" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10767540, 11567005" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10767540, 11567005; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="sporulation specific penicillin-binding protein 2D" /protein_id="NP_391631.2" /db_xref="EnsemblGenomes-Gn:BSU37510" /db_xref="EnsemblGenomes-Tr:CAB15778" /db_xref="GOA:P70997" /db_xref="InterPro:IPR001264" /db_xref="InterPro:IPR001460" /db_xref="InterPro:IPR012338" /db_xref="InterPro:IPR023346" /db_xref="InterPro:IPR036950" /db_xref="SubtiList:BG12459" /db_xref="UniProtKB/Swiss-Prot:P70997" /translation="MDAMTNKRLRLTLKTVRAFIFLGAFAALAAAAVFMTVILIAKYQ GAPSVQVPQSTILYASDGSKLGETNYGEKRYWVPLKDMNPTIVKATVAIEDQNFYDHH GFDYKRMAGAALADLKAFAKVQGASTITQQYARNLYLEHDKTWKRKWNEAFYTIRLEQ NYSKDEILEGYLNTIYYGHGAYGIEAASRLYFGKHAKNLTDAEAALLAGIPKGPSGYS PYVNETKAKERQKTIVRMMEKQQMISQKKADELIKEPLSYQPLNKQVSKRKAPYFYDN AMRELEKKLGMTREQIETSGLNVYTTVDKRMQRIAEETITETVNAGSDIQVGFSAIDP RTGNVLALVGGRDYQKSPFDRTTQAKRQPASTIKPLLYYKAIQSGFTPVTLMKSEETE FQIDAKGETYSPSNYNGYYANKPITLLQALALSDNIYAVKTHLFLGTNKLVKTAKEFG ITAHLQALPSLALGTEPVRPIEMVNAYAMLANGGKKIEPTFISRVTDAAGHVLYENPN QHKQVLDEKAAFVTASMMTGMFDIDLNGYTSVTGRTIANRLTRTYAGKSGTTSADSWM IGFNPKLAAGVWTGYDKNSTIDSVEEKSYAKTIWADFMEDALKGEPETAFKPPKGVTG VYIDPETGYSSGPGCAAKHYTYFVKGTEPANVCYGAEPAKQTKDRLPSKEKPASEKKW WDKWLGRHH*" /label="pbpG CDS" gene 3500933..3503008 /gene="pbpG" /locus_tag="BSU_37510" /old_locus_tag="BSU37510" /label="pbpG gene" downshifts complement(3503061) /Source="Nicolas_upshifts" /id="D1943" /incds=0 /nref=2 /ntot=122 /MaxReadThrough="1.43573" /MaxDrop="3.61075" /score="-7.59753556" /energy="-10.7" /TU="NA" /idTUdmin="U2951" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" S_feature complement(3503185..3503300) /Source="Nicolas_S_feature" /locus_tag="new_3852070_3852185_c" /HighExp="Sw, C90, BI, dia5, dia15, Diami, LBGexp, M0t45, Lbexp, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1453" downshifts complement(3503228) /Source="Nicolas_upshifts" /id="D1944" /incds=0 /nref=198 /ntot=248 /MaxReadThrough="3.25498" /MaxDrop="6.4287" /score="-7.59753556" /energy="-10.7" /TU="U2951,U2952" /idTUdmin="U2952" /TUdmin="-156" /isTUend="FALSE" /label="downshifts" CDS complement(3503301..3503819) /gene="ywhD" /locus_tag="BSU_37520" /old_locus_tag="BSU37520" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391632.1" /db_xref="EnsemblGenomes-Gn:BSU37520" /db_xref="EnsemblGenomes-Tr:CAB15779" /db_xref="InterPro:IPR014852" /db_xref="SubtiList:BG12458" /db_xref="UniProtKB/Swiss-Prot:P70996" /translation="MEEKKKKSIGFNIIKSDPTDGHGGFGVGALSLDNISPVFVDVEE KEAFVDIGAMHARSTVEKGIKFLPNKEEVPNGKPYWLVWVTIDRKEEGPYYAGVTACE MTVDRSIRRGYKSLPEHVNLMDKSMKRKIIVDKMDDSSKRVLGEFLKKHDQGLWDRSS DELKTSLLPENN*" /label="ywhD CDS" gene complement(3503301..3503819) /gene="ywhD" /locus_tag="BSU_37520" /old_locus_tag="BSU37520" /label="ywhD gene" CDS complement(3503833..3504492) /gene="ywhC" /locus_tag="BSU_37530" /old_locus_tag="BSU37530" /EC_number="3.4.24.-" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 25649915; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent hydrolase; integral membrane protein" /protein_id="NP_391633.1" /db_xref="EnsemblGenomes-Gn:BSU37530" /db_xref="EnsemblGenomes-Tr:CAB15780" /db_xref="GOA:P70995" /db_xref="InterPro:IPR008915" /db_xref="SubtiList:BG12457" /db_xref="UniProtKB/Swiss-Prot:P70995" /translation="MDRFLYYPLSLMPYLVITLIVSFTMHELAHAYVAYKFGDDTAKK QGRLTLNPIKHLDPFGTILILVAGFGWARPIPVNRRFFKKPRLAGVLVSIAGPVSNLI LAFIGFFLLVLMHAYGMEMLAAFSTGLDQFFSIWIQLNLVLFLFNLLPLPPLDGYRII EDLVPPGVRAKMTQAESYGFIVFLVLFVTPLGSYVLWPMLNAGRDSILKLFSAIFQPL L*" /label="ywhC CDS" gene complement(3503833..3504492) /gene="ywhC" /locus_tag="BSU_37530" /old_locus_tag="BSU37530" /label="ywhC gene" promotor_-35 3504515..3504518 /Source="Nicolas_upshift_promotors" /id="U2950" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.919080919080919" /psig="0.993006993006993" /xcortree=2205 /SigmaFactorBS="tataaaaaacggtccaagtgagatatccctctttctcaaAAT GcaagaatttactttATTCAGTATACTATAAGAAGcctctttttctaaagagaggaaa c" /listShort="ywhB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3504528..3504547) /Source="Nicolas_upshift_promotors" /id="U2951" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.549450549450549" /psig=1 /xcortree=1882 /SigmaFactorBS="tggcatgggtgctgaatcctcctttatctcgtttcctCTCTT TAGaaaaagaggcttctTATAGTATACTGAATAAAGTaaattcttgcattttgagaaa g" /listShort="ywhC, ywhD, S1453" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 3504533..3504552 /Source="Nicolas_upshift_promotors" /id="U2950" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.919080919080919" /psig="0.993006993006993" /xcortree=2205 /SigmaFactorBS="tataaaaaacggtccaagtgagatatccctctttctcaaAAT GcaagaatttactttATTCAGTATACTATAAGAAGcctctttttctaaagagaggaaa c" /listShort="ywhB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3504536 /Source="Nicolas_upshifts" /id="U2950" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.919080919080919" /psig="0.993006993006993" /xcortree=2205 /SigmaFactorBS="tataaaaaacggtccaagtgagatatccctctttctcaaAAT GcaagaatttactttATTCAGTATACTATAAGAAGcctctttttctaaagagaggaaa c" /listShort="ywhB" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(3504546) /Source="Nicolas_upshifts" /id="U2951" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.549450549450549" /psig=1 /xcortree=1882 /SigmaFactorBS="tggcatgggtgctgaatcctcctttatctcgtttcctCTCTT TAGaaaaagaggcttctTATAGTATACTGAATAAAGTaaattcttgcattttgagaaa g" /listShort="ywhC, ywhD, S1453" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3504548..3504831) /Source="Nicolas_S_feature" /locus_tag="new_3853433_3853716_c" /HighExp="Diami, dia5, dia15, C90, Etha, Sw, H2O2, G135, M40t45, Lbtran" /AntisenseName="ywhB" /AntisenseCor="0.10541372702249199" /AntisenseRegPval="-1.1000000000000001" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1454" promotor_-35 complement(3504562..3504569) /Source="Nicolas_upshift_promotors" /id="U2951" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.549450549450549" /psig=1 /xcortree=1882 /SigmaFactorBS="tggcatgggtgctgaatcctcctttatctcgtttcctCTCTT TAGaaaaagaggcttctTATAGTATACTGAATAAAGTaaattcttgcattttgagaaa g" /listShort="ywhC, ywhD, S1453" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3504601..3504789 /gene="hmtB" /locus_tag="BSU_37540" /old_locus_tag="BSU37540" /EC_number="5.3.2.6" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12051677, 14624569, 14730980, 15301547, 17902707" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12051677, 14624569, 14730980, 15301547, 17902707; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-hydroxymuconate tautomerase (promiscuous)" /protein_id="NP_391634.1" /db_xref="EnsemblGenomes-Gn:BSU37540" /db_xref="EnsemblGenomes-Tr:CAB15781" /db_xref="GOA:P70994" /db_xref="InterPro:IPR004370" /db_xref="InterPro:IPR014347" /db_xref="InterPro:IPR018191" /db_xref="PDB:2OP8" /db_xref="PDB:2OPA" /db_xref="SubtiList:BG12456" /db_xref="UniProtKB/Swiss-Prot:P70994" /translation="MPYVTVKMLEGRTDEQKRNLVEKVTEAVKETTGASEEKIVVFIE EMRKDHYAVAGKRLSDME*" /label="hmtB CDS" gene 3504601..3504789 /gene="hmtB" /locus_tag="BSU_37540" /old_locus_tag="BSU37540" /label="hmtB gene" downshifts 3504778 /Source="Nicolas_upshifts" /id="D1945" /incds=0 /nref=72 /ntot=213 /MaxReadThrough="1.74275" /MaxDrop="4.93207" /score="4.21502693" /energy="-10.5" /TU="NA" /idTUdmin="U2950" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3504832..3505251) /gene="ywhA" /locus_tag="BSU_37550" /old_locus_tag="BSU37550" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MarR family)" /protein_id="NP_391635.1" /db_xref="EnsemblGenomes-Gn:BSU37550" /db_xref="EnsemblGenomes-Tr:CAB15782" /db_xref="GOA:P70993" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12455" /db_xref="UniProtKB/Swiss-Prot:P70993" /translation="MDHDKLEANLLDHALTKYLKSTKQLDEATVPKHVNNVRGFILRI IYRHGSCTIKDILKEVTLSPSATTTALNHLEQEGFIERSRNNNDRRTVWITLSESGRG AAEQMIENRQQLIDGMFERLTAEEKKTFLAIIAKLAQ*" /label="ywhA CDS" gene complement(3504832..3505251) /gene="ywhA" /locus_tag="BSU_37550" /old_locus_tag="BSU37550" /label="ywhA gene" promotor_-10 complement(3505301..3505320) /Source="Nicolas_upshift_promotors" /id="U2952" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.635364635364635" /psig="0.999000999001" /xcortree=1951 /SigmaFactorBS="aggataaaagctgtgaattcacattttgctTTTTTGACtttc cctattcggaATCAGTAAAATAATAAGTAAatcatatcgttcgtatgttatgaatgca t" /listShort="ywhA, S1454, ywhC, ywhD, S1453" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3505312) /Source="Nicolas_upshifts" /id="U2952" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.635364635364635" /psig="0.999000999001" /xcortree=1951 /SigmaFactorBS="aggataaaagctgtgaattcacattttgctTTTTTGACtttc cctattcggaATCAGTAAAATAATAAGTAAatcatatcgttcgtatgttatgaatgca t" /listShort="ywhA, S1454, ywhC, ywhD, S1453" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3505335..3505342) /Source="Nicolas_upshift_promotors" /id="U2952" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.635364635364635" /psig="0.999000999001" /xcortree=1951 /SigmaFactorBS="aggataaaagctgtgaattcacattttgctTTTTTGACtttc cctattcggaATCAGTAAAATAATAAGTAAatcatatcgttcgtatgttatgaatgca t" /listShort="ywhA, S1454, ywhC, ywhD, S1453" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3505371..3507287) /gene="thrZ" /locus_tag="BSU_37560" /old_locus_tag="BSU37560" /EC_number="6.1.1.3" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1379177, 8288542, 9353933, 15831787" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1379177, 8288542, 9353933, 15831787; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="threonyl-tRNA synthetase" /protein_id="NP_391636.2" /db_xref="EnsemblGenomes-Gn:BSU37560" /db_xref="EnsemblGenomes-Tr:CAB15783" /db_xref="GOA:P18256" /db_xref="InterPro:IPR002314" /db_xref="InterPro:IPR002320" /db_xref="InterPro:IPR004095" /db_xref="InterPro:IPR004154" /db_xref="InterPro:IPR006195" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR012676" /db_xref="InterPro:IPR012947" /db_xref="InterPro:IPR018163" /db_xref="InterPro:IPR033728" /db_xref="InterPro:IPR036621" /db_xref="SubtiList:BG10421" /db_xref="UniProtKB/Swiss-Prot:P18256" /translation="MSKHVHIQLPDGQIQEYPKGITIKEAAGSISSSLQKKAAAGQVN GKLVDLSFKLEEDAELSIVTLDSQEGLQVLRHTTAHVLAQAVKRLYGEVSLGVGPVIL DGFYYDMKLGKSLASGDLEAIEKEMKNIINENLEIKRIEVSYEEAEELFAQKDERLKL EILKDIPRGEDITLYQQGEFVDLCRGPHLPSTGMIKAFKLTRVSGAYWRGDSKNEVLQ RVYGVAFQKKKDLDAHLHMLEEAAKRDHRKLGKQLGLFMFSEEAPGMPFYLPKGQIVR NELERFSRELQTNAGYDEVRTPFMMNQRLWEQSGHWDHYRDNMYFSEVDDTRFAMKPM NCPGHMLIFKNSLYSYRDLPIRMAEFGQVHRHEYSGALNGMLRVRTFCQDDAHIFVRE DQIESEIKEAIRLIDEVYRTFGFEYSVELSTRPEDSLGDDSLWEASERALARVLEELG LSYEINEGDGAFYGPKIDFHIKDALKRSHQCATIQLDFQMPEKFDLTYINELNEKVRP VVIHRAVFGSIDRFFGILIEHYGGAFPVWLAPIQVQIIPVSHVHLDYCRKVQAELKQA GIRAGIDERNEKLGYKIRESQVQKIPYVLVLGDHEEQENAVNVRRFGHQQNEHVPFQT FKDKLVKQVENRGM*" /label="thrZ CDS" gene complement(3505371..3507287) /gene="thrZ" /locus_tag="BSU_37560" /old_locus_tag="BSU37560" /label="thrZ gene" promotor_-10 complement(3506565..3506583) /Source="Nicolas_upshift_promotors" /id="U2953" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.713286713286713" /psig="0.713286713286713" /xcortree=1064 /SigmaFactorBS="gtgtacggggttgcgtttcaaaagaaAAAAGatttggatgcg cacctGCATATGCTAGAAGAAGCGgcaaaacgagaccatcgcaagctcggcaaacagt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3506570) /Source="Nicolas_upshifts" /id="U2953" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.713286713286713" /psig="0.713286713286713" /xcortree=1064 /SigmaFactorBS="gtgtacggggttgcgtttcaaaagaaAAAAGatttggatgcg cacctGCATATGCTAGAAGAAGCGgcaaaacgagaccatcgcaagctcggcaaacagt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3506600..3506604) /Source="Nicolas_upshift_promotors" /id="U2953" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.713286713286713" /psig="0.713286713286713" /xcortree=1064 /SigmaFactorBS="gtgtacggggttgcgtttcaaaagaaAAAAGatttggatgcg cacctGCATATGCTAGAAGAAGCGgcaaaacgagaccatcgcaagctcggcaaacagt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3507318) /Source="Nicolas_upshifts" /id="D1946" /incds=0 /nref=1 /ntot=27 /MaxReadThrough="4.2774" /MaxDrop="3.56231" /score="36.3785359" /energy="-19.5" /TU="U2955" /idTUdmin="U2953" /TUdmin="-968" /isTUend="FALSE" /label="downshifts" misc_RNA complement(3507341..3507562) /gene="tboTB" /locus_tag="BSU_misc_RNA_57" /product="T-box" /experiment="publication(s) with functional evidences, PMID:1379177, 8288542, 9098041, 9826762, 12165569, 12547201, 1317842, 15831787" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1379177, 8288542, 9098041, 9826762, 12165569, 12547201, 1317842, 15831787; Product type n: RNA" /function="16.3: Control" /label="tboTB RNA" gene complement(3507341..3507562) /gene="tboTB" /locus_tag="BSU_misc_RNA_57" /label="tboTB gene" misc_RNA complement(3507594..3507815) /gene="tboTA" /locus_tag="BSU_misc_RNA_58" /product="T-box riboswitch specific of threonine tRNA ligase" /experiment="publication(s) with functional evidences, PMID:1379177, 8288542, 9098041, 9826762, 12165569, 12547201, 1317842, 15831787" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1379177, 8288542, 9098041, 9826762, 12165569, 12547201, 1317842, 15831787; Product type n: RNA" /function="16.3: Control" /label="tboTA RNA" gene complement(3507594..3507815) /gene="tboTA" /locus_tag="BSU_misc_RNA_58" /label="tboTA gene" S_feature complement(3507847..3508109) /Source="Nicolas_S_feature" /locus_tag="new_3856732_3856994_c" /HighExp="S8, S7, S6, S5, BT, Sw, B36, B60, T5.0H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.61719100000000005" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S1455" downshifts 3507858 /Source="Nicolas_upshifts" /id="D1947" /incds=0 /nref=1 /ntot=17 /MaxReadThrough="0.92811" /MaxDrop="3.85666" /score="1.17237511" /energy="-8.3" /TU="NA" /idTUdmin="U2950" /TUdmin=3080 /isTUend="FALSE" /label="downshifts" downshifts complement(3507890) /Source="Nicolas_upshifts" /id="D1948" /incds=0 /nref=52 /ntot=200 /MaxReadThrough="6.68945" /MaxDrop="6.6969" /score="36.414771" /energy="-17.3" /TU="U2955" /idTUdmin="U2953" /TUdmin="-1540" /isTUend="FALSE" /label="downshifts" CDS complement(3507897..3508052) /locus_tag="BSU_37569" /old_locus_tag="BSU37569" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514011.1" /translation="MLFTVSREGRTAEIFLTQGKQLTAFEPYQGKQVSDTVMLRYSIF KPIIMCN*" /label="hypothetical protein CDS" gene complement(3507897..3508052) /locus_tag="BSU_37569" /old_locus_tag="BSU37569" /label="gene" promotor_-35 3508059..3508062 /Source="Nicolas_upshift_promotors" /id="U2954" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.717282717282717" /psig="0.094905094905095" /xcortree=712 /SigmaFactorBS="gctgtccttccctctctggaaaccgtaaaaagcatctcgtgT CCTtatcagtgCCTGTTGTTTCAATaattttttatatcttactatatattcccacaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3508071..3508084 /Source="Nicolas_upshift_promotors" /id="U2954" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.717282717282717" /psig="0.094905094905095" /xcortree=712 /SigmaFactorBS="gctgtccttccctctctggaaaccgtaaaaagcatctcgtgT CCTtatcagtgCCTGTTGTTTCAATaattttttatatcttactatatattcccacaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3508078 /Source="Nicolas_upshifts" /id="U2954" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.717282717282717" /psig="0.094905094905095" /xcortree=712 /SigmaFactorBS="gctgtccttccctctctggaaaccgtaaaaagcatctcgtgT CCTtatcagtgCCTGTTGTTTCAATaattttttatatcttactatatattcccacaaa g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3508086..3508105) /Source="Nicolas_upshift_promotors" /id="U2955" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.457542457542458" /psig="0.995004995004995" /xcortree=601 /SigmaFactorBS="ctgcccataacgggactgccgcgtcagaaaaaatgtaaatca ctGATTGCGctttgtgggaataTATAGTAAGATATAAAAAATtattgaaacaacaggc a" /listShort="S1455, NA, NA, thrZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3508109) /Source="Nicolas_upshifts" /id="U2955" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.457542457542458" /psig="0.995004995004995" /xcortree=601 /SigmaFactorBS="ctgcccataacgggactgccgcgtcagaaaaaatgtaaatca ctGATTGCGctttgtgggaataTATAGTAAGATATAAAAAATtattgaaacaacaggc a" /listShort="S1455, NA, NA, thrZ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3508119..3508125) /Source="Nicolas_upshift_promotors" /id="U2955" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.457542457542458" /psig="0.995004995004995" /xcortree=601 /SigmaFactorBS="ctgcccataacgggactgccgcgtcagaaaaaatgtaaatca ctGATTGCGctttgtgggaataTATAGTAAGATATAAAAAATtattgaaacaacaggc a" /listShort="S1455, NA, NA, thrZ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3508132..3509532) /gene="mmr" /locus_tag="BSU_37570" /old_locus_tag="BSU37570" /function="16.1: Circulate" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:11104814, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11104814, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="toxic compound efflux transporter (may export homoserine)" /protein_id="NP_391637.1" /db_xref="EnsemblGenomes-Gn:BSU37570" /db_xref="EnsemblGenomes-Tr:CAB15784" /db_xref="GOA:Q00538" /db_xref="InterPro:IPR004638" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10420" /db_xref="UniProtKB/Swiss-Prot:Q00538" /translation="MKNSGSIQESTSSTGISVLIVLALGFLMATLDVTVVNVAMADMK NTLSMSLSGVTWVVDGYILTFASLLLAGGALADRFGSKTIYILGLAVFVMASCLCAAS INGQMLIAGRLIQGIGAALFMPSSLSLLAASYLDERARARMFGLWAALVSAASALGPF IGGVLVQLAGWQSIFLINVPIGAAALISAYRILSRVPGKSSRVNIIGHLLGMMALGFL SYALIQGPSAGWRSPVILVAFTAAVLAFVLFLLREISAKTPILPASLYKNGRFSAAQF IGFLLNFALFGGMFMLSLFLQEAGGASSFMAGVELLPMMAVFVIGNLLFARLANRFEA GQLMFVSMAVSCIIALLLFVLISPDFPYWQLAVLMSVMNLCTGITVPAMTTVIMQAAG QRHTNIAGAALNANRQIGALVGVAITGVIIHLSATWYAGAGFAFLMMGAAYSLAALLV WLFLAAHNGTAASEKM*" /label="mmr CDS" gene complement(3508132..3509532) /gene="mmr" /locus_tag="BSU_37570" /old_locus_tag="BSU37570" /label="mmr gene" CDS complement(3509532..3510002) /gene="ywgB" /locus_tag="BSU_37580" /old_locus_tag="BSU37580" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16885456; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_391638.1" /db_xref="EnsemblGenomes-Gn:BSU37580" /db_xref="EnsemblGenomes-Tr:CAB15785" /db_xref="GOA:P71047" /db_xref="InterPro:IPR000944" /db_xref="InterPro:IPR030489" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG12454" /db_xref="UniProtKB/Swiss-Prot:P71047" /translation="MKMKSGMEQAVSVLLLLSRLPVQASLTSEAISQRLRVSPSYLKK LMRTLVQAGLAESLPGTKGGFTLTKPLADITLYDVYQAVEGRGSMYQGKGLLQSVFEG ESHCVLETVMAEIEDKWSNLMREESLQHVMDRVGELYDLEKIDDWVIKQVKGQL*" /label="ywgB CDS" gene complement(3509532..3510002) /gene="ywgB" /locus_tag="BSU_37580" /old_locus_tag="BSU37580" /label="ywgB gene" downshifts complement(3509958) /Source="Nicolas_upshifts" /id="D1949" /incds=0 /nref=11 /ntot=145 /MaxReadThrough="2.78131" /MaxDrop="4.29115" /score="17.3758052" /energy="-11.2" /TU="NA" /idTUdmin="U2956" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3510114..3510614) /gene="ywgA" /locus_tag="BSU_37590" /old_locus_tag="BSU37590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16855250" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391639.1" /db_xref="EnsemblGenomes-Gn:BSU37590" /db_xref="EnsemblGenomes-Tr:CAB15786" /db_xref="SubtiList:BG12453" /db_xref="UniProtKB/Swiss-Prot:P71046" /translation="MLKEHAKLMKVFSDSGEIIGRKKLQKMIYIAKKMQFPFYEKYDF HFYGPYSEELTLQIEELCNLGFLHEVKEKKGGYFQYRYSLTETGSAFLDHADLDMPDM KGYIDSVNSRSSRFLELVSTILYFDGLEDEEKKEKVFTIKSKQKYTNEEYDEALQYIE ELKQIC*" /label="ywgA CDS" gene complement(3510114..3510614) /gene="ywgA" /locus_tag="BSU_37590" /old_locus_tag="BSU37590" /label="ywgA gene" downshifts complement(3510117) /Source="Nicolas_upshifts" /id="D1950" /incds=0 /nref=9 /ntot=105 /MaxReadThrough="4.00805" /MaxDrop="6.12059" /score="17.3758052" /energy="-11.2" /TU="U2956,U2957" /idTUdmin="U2957" /TUdmin="-137" /isTUend="FALSE" /label="downshifts" CDS complement(3510650..3511951) /gene="ywfO" /locus_tag="BSU_37600" /old_locus_tag="BSU37600" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16855250; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative metal-dependent nucleotide (pyro)phosphohydrolase" /protein_id="NP_391640.1" /db_xref="EnsemblGenomes-Gn:BSU37600" /db_xref="EnsemblGenomes-Tr:CAB15787" /db_xref="GOA:P39651" /db_xref="InterPro:IPR003607" /db_xref="InterPro:IPR006674" /db_xref="SubtiList:BG10639" /db_xref="UniProtKB/Swiss-Prot:P39651" /translation="MAYPNGKLSEEKVFKDPVHRYVHVRDKLIWDLIGTREFQRLRRI KQLGTTYLTFHGAEHSRFNHSLGVYEIVRRMVDDVFKGRPEWDDSERELCLAAALLHD LGHGPFSHSFEKVFHLDHEDFTRGIILGDTEVNQVLRKVSPGFPQDVAEVIAKTYKNK QVVSLISSQIDADRMDYLQRDAYYTGVSYGHFDMERILRVMRPREDQIVIKESGMHAV EDYIMSRYQMYWQVYFHPVTRSAEVILTKILHRAKQLHDEGYVFTHAPVHFYSIFEGK LTLEDYVKLDESIILYYFQAWEDEEDAILSDLCRRFINRQLFQYVEFNPNEEMSAYFE LTSLFKEAGIDPSYYLVVDSSSDLPYDFYRPGEEEERLPIHLLTQNGQIKELSRQSAI VESISGKRRTDHKLYYPKDLICDGTKHPEAKMKIRQLLGLT*" /label="ywfO CDS" gene complement(3510650..3511951) /gene="ywfO" /locus_tag="BSU_37600" /old_locus_tag="BSU37600" /label="ywfO gene" promotor_-10 complement(3511975..3511994) /Source="Nicolas_upshift_promotors" /id="U2956" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig="0.992007992007992" /xcortree=2244 /SigmaFactorBS="tcatgaagatggaacaaatcgccgggcaaattcaaggATGtt ttcaaagaatagaGTCGATATAATAGAAACACGgctaaaaaaaagagggaatgacgat g" /listShort="ywfO, ywgA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3511989) /Source="Nicolas_upshifts" /id="U2956" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig="0.992007992007992" /xcortree=2244 /SigmaFactorBS="tcatgaagatggaacaaatcgccgggcaaattcaaggATGtt ttcaaagaatagaGTCGATATAATAGAAACACGgctaaaaaaaagagggaatgacgat g" /listShort="ywfO, ywgA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3511991..3512112) /Source="Nicolas_S_feature" /locus_tag="new_3860876_3860997_c" /HighExp="G180, Paraq, Oxctl, G135, H2O2, G150, C30, LBGstat, LBGexp, Heat" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1456" promotor_-35 complement(3512010..3512012) /Source="Nicolas_upshift_promotors" /id="U2956" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.57042957042957" /psig="0.992007992007992" /xcortree=2244 /SigmaFactorBS="tcatgaagatggaacaaatcgccgggcaaattcaaggATGtt ttcaaagaatagaGTCGATATAATAGAAACACGgctaaaaaaaagagggaatgacgat g" /listShort="ywfO, ywgA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3512113..3512337) /gene="ywzC" /locus_tag="BSU_37610" /old_locus_tag="BSU37610" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16855250" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391641.1" /db_xref="EnsemblGenomes-Gn:BSU37610" /db_xref="EnsemblGenomes-Tr:CAB15788" /db_xref="InterPro:IPR009910" /db_xref="InterPro:IPR020880" /db_xref="SubtiList:BG14164" /db_xref="UniProtKB/Swiss-Prot:O32280" /translation="MANEFRVCDDCQATNIKTLLPRLKEVDPDAKVEVGCQSYCGPGR KKSFAFVNNRPLSAPTEDELIDKVKKKIKK*" /label="ywzC CDS" gene complement(3512113..3512337) /gene="ywzC" /locus_tag="BSU_37610" /old_locus_tag="BSU37610" /label="ywzC gene" S_feature complement(3512338..3512422) /Source="Nicolas_S_feature" /locus_tag="new_3861223_3861307_c" /HighExp="G180, Paraq, H2O2, G135, LBGexp, dia15, G150, Lbexp, Heat, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1457" promotor_-10 complement(3512411..3512430) /Source="Nicolas_upshift_promotors" /id="U2957" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.543456543456543" /psig=1 /xcortree=2595 /SigmaFactorBS="ctgaaagaataggagatacgaaggatggagcggCTTGcagga acagtcgaaTCCTTGTAAAATGAAGTGTGatgtgattttttttgaaacgtgattttag g" /listShort="S1457, ywzC, S1456, ywfO, ywgA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3512421) /Source="Nicolas_upshifts" /id="U2957" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.543456543456543" /psig=1 /xcortree=2595 /SigmaFactorBS="ctgaaagaataggagatacgaaggatggagcggCTTGcagga acagtcgaaTCCTTGTAAAATGAAGTGTGatgtgattttttttgaaacgtgattttag g" /listShort="S1457, ywzC, S1456, ywfO, ywgA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3512445..3512448) /Source="Nicolas_upshift_promotors" /id="U2957" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.543456543456543" /psig=1 /xcortree=2595 /SigmaFactorBS="ctgaaagaataggagatacgaaggatggagcggCTTGcagga acagtcgaaTCCTTGTAAAATGAAGTGTGatgtgattttttttgaaacgtgattttag g" /listShort="S1457, ywzC, S1456, ywfO, ywgA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3512488..3512494 /Source="Nicolas_upshift_promotors" /id="U2958" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.836163836163836" /psig="0.836163836163836" /xcortree=1045 /SigmaFactorBS="cgctccatccttcgtatctcctattctttcagccaattTGTA TAAatattttccaacctGGACATTCTAATaccatgaaaagaaaaatgggagttgagat a" /listShort="rsfA, S1458" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3512509..3512520 /Source="Nicolas_upshift_promotors" /id="U2958" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.836163836163836" /psig="0.836163836163836" /xcortree=1045 /SigmaFactorBS="cgctccatccttcgtatctcctattctttcagccaattTGTA TAAatattttccaacctGGACATTCTAATaccatgaaaagaaaaatgggagttgagat a" /listShort="rsfA, S1458" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3512510 /Source="Nicolas_upshifts" /id="U2958" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.836163836163836" /psig="0.836163836163836" /xcortree=1045 /SigmaFactorBS="cgctccatccttcgtatctcctattctttcagccaattTGTA TAAatattttccaacctGGACATTCTAATaccatgaaaagaaaaatgggagttgagat a" /listShort="rsfA, S1458" /GFF_Attribute="listLong" /label="upshifts" CDS 3512552..3513328 /gene="psrF" /locus_tag="BSU_37620" /old_locus_tag="BSU37620" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10629188, 16497325, 22829778" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10629188, 16497325, 22829778; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="prespore-specific transcription regulatory gene" /protein_id="NP_391642.1" /db_xref="EnsemblGenomes-Gn:BSU37620" /db_xref="EnsemblGenomes-Tr:CAB15789" /db_xref="GOA:P39650" /db_xref="InterPro:IPR014243" /db_xref="InterPro:IPR017877" /db_xref="SubtiList:BG10638" /db_xref="UniProtKB/Swiss-Prot:P39650" /translation="MTKQRQDAWSEENDLLLAETVLRHVREGSTQLNAFEEVGDKLNR TSAACGFRWNAVVRHQYEKALQLAKKQRKQRMRALGNGQPAKKRLLYQPPAVDPEIIQ ETAAEEPVKTETPSVENEQPLMSGEHMPFVDESFKEELASLSHLLSPQTPAAAPEMTM NDVIRFLQNYEGNHEQSSALKMENERLKKENQELQNKTEQLEAEVQKLEKDQKTIQED YETLVKIMNRARKLVLFEEDEHASPSFKMDRNGNLEKLAE*" /label="psrF CDS" gene 3512552..3513328 /gene="psrF" /locus_tag="BSU_37620" /old_locus_tag="BSU37620" /label="psrF gene" downshifts 3513314 /Source="Nicolas_upshifts" /id="D1951" /incds=0 /nref=14 /ntot=78 /MaxReadThrough="4.08166" /MaxDrop="4.36214" /score="-5.88286948" /energy="-14.4" /TU="U2958" /idTUdmin="U2958" /TUdmin="-3036" /isTUend="FALSE" /label="downshifts" promotor_-35 3513416..3513423 /Source="Nicolas_upshift_promotors" /id="U2959" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig=1 /xcortree=2969 /SigmaFactorBS="atccccttttctattgagaaaagagaatttcctcATTTTGCA gccggatcagctatTCTTGTAAAATGAGGCCAAGcttatgtgaatctattaagacatg t" /listShort="S1458, ywfI" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3513438..3513457 /Source="Nicolas_upshift_promotors" /id="U2959" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig=1 /xcortree=2969 /SigmaFactorBS="atccccttttctattgagaaaagagaatttcctcATTTTGCA gccggatcagctatTCTTGTAAAATGAGGCCAAGcttatgtgaatctattaagacatg t" /listShort="S1458, ywfI" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3513442..3517668 /Source="Nicolas_S_feature" /locus_tag="new_3862327_3866553" /HighExp="T1.30H, T2.0H, T1.0H, T2.30H, T0.30H, T3.0H, T3.30H, T4.0H, T5.0H, T0.0H" /AntisenseName="pta" /AntisenseCor="-0.61235087907102503" /AntisenseRegPval="-28.3" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigGF" /TUshortPSig="1, 0.836" /TUlongSig="NA" /TUlongPSig="NA" /label="S1458" upshifts 3513442 /Source="Nicolas_upshifts" /id="U2959" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.962037962037962" /psig=1 /xcortree=2969 /SigmaFactorBS="atccccttttctattgagaaaagagaatttcctcATTTTGCA gccggatcagctatTCTTGTAAAATGAGGCCAAGcttatgtgaatctattaagacatg t" /listShort="S1458, ywfI" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3513472..3514362) /gene="ywfM" /locus_tag="BSU_37630" /old_locus_tag="BSU37630" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative toxic excess metabolite exporter" /protein_id="NP_391643.1" /db_xref="EnsemblGenomes-Gn:BSU37630" /db_xref="EnsemblGenomes-Tr:CAB15790" /db_xref="GOA:P39649" /db_xref="InterPro:IPR000620" /db_xref="InterPro:IPR004779" /db_xref="SubtiList:BG10637" /db_xref="UniProtKB/Swiss-Prot:P39649" /translation="MKGNIYSLFVLIAAFFWGTTGTVQALAPESATPLAFGAFRLLIG GSAMLLAVWISRELHVKNWAWPLVFLAAVCMACYQPLFFTAVKETGIAVGTVIAIGSA PIIAGTLEWAVLKKRPRNSWWIATVLALAGCWLLFSDSSNVRIDVAGVLMALGAGASF AGYTLISKAMMKTQPPRATSAVVFMISAILLTPLLWQLDISWILTPRGLGTSLYIGLI ATCAAYFLFAKGLTGVPASAAVTLSLAEPLTASLLGVFFIGEMLSPSSWLGIALMMLG LLVISAAPRKQKTAEAAHMS*" /label="ywfM CDS" gene complement(3513472..3514362) /gene="ywfM" /locus_tag="BSU_37630" /old_locus_tag="BSU37630" /label="ywfM gene" promotor_no_box complement(3514362..3514462) /Source="Nicolas_upshift_promotors" /id="U2960" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.568431568431568" /psig="0.136863136863137" /xcortree=1729 /SigmaFactorBS="taatcttattttcagataagtccttcttacatacagataacc acgacaaaaagaaaaacgataaaatgacatcagcatccatattaaaggggagaggcag a" /listShort="ywfM" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(3514402) /Source="Nicolas_upshifts" /id="U2960" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.568431568431568" /psig="0.136863136863137" /xcortree=1729 /SigmaFactorBS="taatcttattttcagataagtccttcttacatacagataacc acgacaaaaagaaaaacgataaaatgacatcagcatccatattaaaggggagaggcag a" /listShort="ywfM" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3514530..3515375) /gene="lipL" /locus_tag="BSU_37640" /old_locus_tag="BSU37640" /function="4: Biosynthesis of cofactors, prosthetic groups, and carriers" /experiment="publication(s) with functional evidences, PMID:21338420, 21338421" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21338420, 21338421; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="amidotransferase of the octanoyl moiety from octanoyl-GcvH to the E2 subunit of pyruvate dehydrogenase" /protein_id="NP_391644.1" /db_xref="EnsemblGenomes-Gn:BSU37640" /db_xref="EnsemblGenomes-Tr:CAB15791" /db_xref="GOA:P39648" /db_xref="InterPro:IPR004143" /db_xref="InterPro:IPR024897" /db_xref="SubtiList:BG10636" /db_xref="UniProtKB/Swiss-Prot:P39648" /translation="MANQPIDLLMQPKWRVIDQSSLGPLFDAKQSFAMDDTLCMSVGK GVSPATARSWVHHDTIVLGIQDTRLPFLQDGISLLESEGYRVIVRNSGGLAVVLDDGV LNISLIFEDEKKGIDIDKGYEAMVELMRRMLRPYNAKIEAYEIEGSYCPGSYDLSING KKFAGISQRRVRGGVAVQIYLCADKSGSERADLIRRFYQAALKDKQNDKKGVYPEIRP ETMASLSELLQKDISVQDLMFALLTELKALSTHLYSAGLSIDEEMEFEKNLVRMAERN AKVFG*" /label="lipL CDS" gene complement(3514530..3515375) /gene="lipL" /locus_tag="BSU_37640" /old_locus_tag="BSU37640" /label="lipL gene" downshifts complement(3514693) /Source="Nicolas_upshifts" /id="D1952" /incds=1 /nref=4 /ntot=180 /MaxReadThrough="3.21908" /MaxDrop="3.30122" /score="31.9003746" /energy="-18.6" /TU="U2961" /idTUdmin="U2961" /TUdmin="-27" /isTUend="FALSE" /label="downshifts" CDS complement(3515424..3516323) /gene="cysL" /locus_tag="BSU_37650" /old_locus_tag="BSU37650" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12169591" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12169591; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of sulfur assimilation CysL, activatescysJI expression" /protein_id="NP_391645.1" /db_xref="EnsemblGenomes-Gn:BSU37650" /db_xref="EnsemblGenomes-Tr:CAB15792" /db_xref="GOA:P39647" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10635" /db_xref="UniProtKB/Swiss-Prot:P39647" /translation="MYYDVLKTFIAVVEEKNFTKAAEKLMISQPSVSLHIKNLEKEFQ TALLNRSPKHFTTTPTGDILYQRAKQMVFLYEQAKAEIYAHHHYVKGELKIAASFTIG EYILPPLLAQLQKLYPELNLDVMIGNTEEVSERVRMLQADIGLIEGHTNENELEIEPF MEDEMCIAAPNQHPLAGRKEISISDLQNEAWVTREKGSGTREYLDHVLSSNGLRPKSM FTISSNQGVKEAVINGMGLSVLSRSVLRKDLIHREISILHINNFSLKRKLSYIHSPLM ENTKNKEIFITMLKSNYQSQLLK*" /label="cysL CDS" gene complement(3515424..3516323) /gene="cysL" /locus_tag="BSU_37650" /old_locus_tag="BSU37650" /label="cysL gene" promotor_-10 complement(3516366..3516385) /Source="Nicolas_upshift_promotors" /id="U2961" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.643356643356643" /psig="0.988011988011988" /xcortree=1930 /SigmaFactorBS="ttttttgcgcttctgtatagcccTTCTTTACcaagacggatg atATGAGTACAATAAAGAAAACtaatcataaccatatatttcattaatgacaggggtg g" /listShort="cysL, ywfL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3516369) /Source="Nicolas_upshifts" /id="U2961" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.643356643356643" /psig="0.988011988011988" /xcortree=1930 /SigmaFactorBS="ttttttgcgcttctgtatagcccTTCTTTACcaagacggatg atATGAGTACAATAAAGAAAACtaatcataaccatatatttcattaatgacaggggtg g" /listShort="cysL, ywfL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3516399..3516406) /Source="Nicolas_upshift_promotors" /id="U2961" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.643356643356643" /psig="0.988011988011988" /xcortree=1930 /SigmaFactorBS="ttttttgcgcttctgtatagcccTTCTTTACcaagacggatg atATGAGTACAATAAAGAAAACtaatcataaccatatatttcattaatgacaggggtg g" /listShort="cysL, ywfL" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3516470) /Source="Nicolas_upshifts" /id="D1953" /incds=0 /nref=222 /ntot=251 /MaxReadThrough="1.96406" /MaxDrop="7.24606" /score="32.3178773" /energy="-17.3" /TU="NA" /idTUdmin="U2962" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3516470..3517441) /gene="pta" /locus_tag="BSU_37660" /old_locus_tag="BSU37660" /EC_number="2.3.1.8" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:4201530, 10559153, 10809684, 16283428, 17183215, 17233734, 21453533, 23468065, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 4201530, 10559153, 10809684, 16283428, 17183215, 17233734, 21453533, 23468065, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphotransacetylase" /protein_id="NP_391646.1" /db_xref="EnsemblGenomes-Gn:BSU37660" /db_xref="EnsemblGenomes-Tr:CAB15793" /db_xref="GOA:P39646" /db_xref="InterPro:IPR002505" /db_xref="InterPro:IPR004614" /db_xref="InterPro:IPR012147" /db_xref="PDB:1TD9" /db_xref="PDB:1XCO" /db_xref="SubtiList:BG10634" /db_xref="UniProtKB/Swiss-Prot:P39646" /translation="MADLFSTVQEKVAGKDVKIVFPEGLDERILEAVSKLAGNKVLNP IVIGNENEIQAKAKELNLTLGGVKIYDPHTYEGMEDLVQAFVERRKGKATEEQARKAL LDENYFGTMLVYKGLADGLVSGAAHSTADTVRPALQIIKTKEGVKKTSGVFIMARGEE QYVFADCAINIAPDSQDLAEIAIESANTAKMFDIEPRVAMLSFSTKGSAKSDETEKVA DAVKIAKEKAPELTLDGEFQFDAAFVPSVAEKKAPDSEIKGDANVFVFPSLEAGNIGY KIAQRLGNFEAVGPILQGLNMPVNDLSRGCNAEDVYNLALITAAQAL*" /label="pta CDS" gene complement(3516470..3517441) /gene="pta" /locus_tag="BSU_37660" /old_locus_tag="BSU37660" /label="pta gene" promotor_-10 complement(3517476..3517495) /Source="Nicolas_upshift_promotors" /id="U2962" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.808191808191808" /psig="0.974025974025974" /xcortree=2697 /SigmaFactorBS="tagaaaaataagatttttttatgaaagcgctataatgaaagt tggcTGTTTgaatttgattggaagAAGAGTATGCTAGTAAAAGAaagcgtttttgtaa c" /listShort="pta" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3517501) /Source="Nicolas_upshifts" /id="U2962" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.808191808191808" /psig="0.974025974025974" /xcortree=2697 /SigmaFactorBS="tagaaaaataagatttttttatgaaagcgctataatgaaagt tggcTGTTTgaatttgattggaagAAGAGTATGCTAGTAAAAGAaagcgtttttgtaa c" /listShort="pta" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3517511..3517515) /Source="Nicolas_upshift_promotors" /id="U2962" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.808191808191808" /psig="0.974025974025974" /xcortree=2697 /SigmaFactorBS="tagaaaaataagatttttttatgaaagcgctataatgaaagt tggcTGTTTgaatttgattggaagAAGAGTATGCTAGTAAAAGAaagcgtttttgtaa c" /listShort="pta" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3517589..3517600) /Source="Nicolas_upshift_promotors" /id="U2963" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=874 /SigmaFactorBS="ttctactgtggagaaaccttgaacatcccttcCGTATAActc catcaaaataGAAGAACCTATAagggaagattgagtcacttaaattagttagaaaaat a" /listShort="pta" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3517592) /Source="Nicolas_upshifts" /id="U2963" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=874 /SigmaFactorBS="ttctactgtggagaaaccttgaacatcccttcCGTATAActc catcaaaataGAAGAACCTATAagggaagattgagtcacttaaattagttagaaaaat a" /listShort="pta" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3517614..3517620) /Source="Nicolas_upshift_promotors" /id="U2963" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=874 /SigmaFactorBS="ttctactgtggagaaaccttgaacatcccttcCGTATAActc catcaaaataGAAGAACCTATAagggaagattgagtcacttaaattagttagaaaaat a" /listShort="pta" /GFF_Attribute="listLong" /label="promotor_-35" misc_feature 3517663..3517682 /Source="Nicolas_upshift_promotors" /id="U2964" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.821178821178821" /psig=1 /xcortree=1605 /SigmaFactorBS="ggagttatacggaagggatgttcaaggtttctccacagtaga atcggataaacTATGGTATAGTGAAGGCAATcatgaaaagataatgggagtgaagata a" /listShort="ywfI, ywfH" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3517670 /Source="Nicolas_upshifts" /id="U2964" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.821178821178821" /psig=1 /xcortree=1605 /SigmaFactorBS="ggagttatacggaagggatgttcaaggtttctccacagtaga atcggataaacTATGGTATAGTGAAGGCAATcatgaaaagataatgggagtgaagata a" /listShort="ywfI, ywfH" /GFF_Attribute="listLong" /label="upshifts" CDS 3517711..3518475 /gene="hemQ" /locus_tag="BSU_37670" /old_locus_tag="BSU37670" /EC_number="4.1.-.-" /function="4.3: Heme, porphyrin, and cobalamin" /experiment="publication(s) with functional evidences, PMID:15317589, 16403788, 20543190, 25711532, 26083961, 27599156, 27758026, 27597779, 27936663, 27982566" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15317589, 16403788, 20543190, 25711532, 26083961, 27599156, 27758026, 27597779, 27936663, 27982566; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="iron-coproporphyrin (coproheme) decarboxylase" /protein_id="NP_391647.3" /db_xref="EnsemblGenomes-Gn:BSU37670" /db_xref="EnsemblGenomes-Tr:CAB15794" /db_xref="GOA:P39645" /db_xref="InterPro:IPR010644" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR031332" /db_xref="SubtiList:BG10633" /db_xref="UniProtKB/Swiss-Prot:P39645" /translation="MSEQQMTNEAAKTLDGWYALHDFRTMDWASWKLLSSDERQSIIH EFTGLLEKWGVAQKEGKGSQTLYSIVGQKADFMLMILRPTMEELNQIELEFNKSRLAE FTIPAYSYVSVVELSNYLASGDGDPYENPHVRARLYPELPESKYVCFYPMDKRRSGND NWYMLSMEERRNLMRSHGLIGRSYAGKVKQIITGSVGFDDYEWGVTLFSDDVLQFKKL VYEMRFDEVSARYGEFGSFFVGNHLSLDTLPQFLYV*" /label="hemQ CDS" gene 3517711..3518475 /gene="hemQ" /locus_tag="BSU_37670" /old_locus_tag="BSU37670" /label="hemQ gene" downshifts 3518462 /Source="Nicolas_upshifts" /id="D1954" /incds=0 /nref=155 /ntot=246 /MaxReadThrough="5.49286" /MaxDrop="6.26609" /score="19.319449" /energy="-14.5" /TU="U2964" /idTUdmin="U2959" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 3518538..3518544 /Source="Nicolas_upshift_promotors" /id="U2965" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.383616383616384" /psig="0.999000999001" /xcortree=2901 /SigmaFactorBS="ttcaattctcctttatcagaatttaaataaaATTTGCTattt tcttcgtttTTTCTTACGATGTAGATAATaatccatttttttcaaaggggtgcagtta t" /listShort="ywfH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3518558..3518577 /Source="Nicolas_upshift_promotors" /id="U2965" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.383616383616384" /psig="0.999000999001" /xcortree=2901 /SigmaFactorBS="ttcaattctcctttatcagaatttaaataaaATTTGCTattt tcttcgtttTTTCTTACGATGTAGATAATaatccatttttttcaaaggggtgcagtta t" /listShort="ywfH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3518567 /Source="Nicolas_upshifts" /id="U2965" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.383616383616384" /psig="0.999000999001" /xcortree=2901 /SigmaFactorBS="ttcaattctcctttatcagaatttaaataaaATTTGCTattt tcttcgtttTTTCTTACGATGTAGATAATaatccatttttttcaaaggggtgcagtta t" /listShort="ywfH" /GFF_Attribute="listLong" /label="upshifts" CDS 3518608..3519387 /gene="bacG" /locus_tag="BSU_37680" /old_locus_tag="BSU37680" /EC_number="1.3.1.-" /function="16.8: Protect" /function="16.4: Excrete" /experiment="publication(s) with functional evidences, PMID:12372825, 20052993, 23519407, 25644640" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12372825, 20052993, 23519407, 25644640; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cyclohexenol-containing tetrahydro-4-hydroxyphenylpyruvate H(4)HPP in bacilysin synthesis" /protein_id="NP_391648.1" /db_xref="EnsemblGenomes-Gn:BSU37680" /db_xref="EnsemblGenomes-Tr:CAB15795" /db_xref="GOA:P39644" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR036291" /db_xref="PDB:3U49" /db_xref="PDB:3U4C" /db_xref="PDB:3U4D" /db_xref="SubtiList:BG10632" /db_xref="UniProtKB/Swiss-Prot:P39644" /translation="MSKRTAFVMGASQGIGKAIALKLADQHFSLVINSRNLDNIESVK EDILAKHPEASVIVLAGDMSDQHTRAGIFQKIESQCGRLDVLINNIPGGAPDTFDNCN IEDMTATFTQKTVAYIDAIKRASSLMKQNEFGRIINIVGNLWKEPGANMFTNSMMNAA LINASKNISIQLAPHNITVNCLNPGFIATDRYHQFVENVMKKNSISKQKAEEQIASGI PMKRVGSAEETAALAAFLASEEASYITGQQISADGGSMKSI*" /label="bacG CDS" gene 3518608..3519387 /gene="bacG" /locus_tag="BSU_37680" /old_locus_tag="BSU37680" /label="bacG gene" downshifts 3519364 /Source="Nicolas_upshifts" /id="D1955" /incds=0 /nref=84 /ntot=226 /MaxReadThrough="3.12719" /MaxDrop="4.87473" /score="3.07615905" /energy="-11.9" /TU="U2965" /idTUdmin="U2964" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3519402..3520601) /gene="bacF" /locus_tag="BSU_37690" /old_locus_tag="BSU37690" /function="16.4: Excrete" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12372825, 12670965, 15609023, 20052993, 18957859, 19061923, 25261512, 25472439, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12372825, 12670965, 15609023, 20052993, 18957859, 19061923, 25261512, 25472439, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phenylalanine aminotransferase forming tetrahydrotyrosine in bacilysin synthesis" /protein_id="NP_391649.1" /db_xref="EnsemblGenomes-Gn:BSU37690" /db_xref="EnsemblGenomes-Tr:CAB15796" /db_xref="GOA:P39643" /db_xref="InterPro:IPR004838" /db_xref="InterPro:IPR004839" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG10631" /db_xref="UniProtKB/Swiss-Prot:P39643" /translation="MEITPSDVIKTLPRQEFSLVFQKVKEMEKTGAHIINLGQGNPDL PTPPHIVEALREASLNPSFHGYGPFRGYPFLKEAIAAFYKREYGVTINPETEVALFGG GKAGLYVLTQCLLNPGDIALVPNPGYPEYLSGITMARAELYEMPLYEENGYLPDFEKI DPAVLEKAKLMFLNYPNNPTGAVADAAFYAKAAAFAKEHNIHLIHDFAYGAFEFDQKP ASFLEAEDAKTVGAELYSFSKTFNMAGWRMAFAVGNEKIIQAVNEFQDHVFVGMFGGL QQAASAALSGDPEHTESLKRIYKERIDFFTALCEKELGWKMEKPKGTFYVWAEIPNTF ETSHQFSDYLLEHAHVVVTPGEIFGSNGKRHVRISMVSKQEDLREFVTRIQKLNLPFG SLQETSR*" /label="bacF CDS" gene complement(3519402..3520601) /gene="bacF" /locus_tag="BSU_37690" /old_locus_tag="BSU37690" /label="bacF gene" CDS complement(3520602..3521786) /gene="bacE" /locus_tag="BSU_37700" /old_locus_tag="BSU37700" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12372825, 15609023, 15849754, 16850406, 18957859, 19061923, 25261512, 25472439, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12372825, 15609023, 15849754, 16850406, 18957859, 19061923, 25261512, 25472439, 26284661; Product type t: transporter" /codon_start=1 /transl_table=11 /product="efflux protein for bacilysin excretion, self-protection against bacilysin" /protein_id="NP_391650.1" /db_xref="EnsemblGenomes-Gn:BSU37700" /db_xref="EnsemblGenomes-Tr:CAB15797" /db_xref="GOA:P39642" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR022324" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10630" /db_xref="UniProtKB/Swiss-Prot:P39642" /translation="MKQLKPNSKYLLYGQALSFMGDYCVLPALLILSTYYHDYWVTSG VIVVRSIPMVFQPFLGVLVDRLDRIKIMLWTDIIRGIIFLGLTFLPKGEYPLIFLALL FITYGSGVFFNPARLAVMSSLESDIKSINTLFAKATTISIIVGAAAGGLFLLGGSVEL AVAFNGVTYLVSAFFISRIKLQFVPIQSENIKEAFQSFKEGLKEIKTNSFVLNAMFTM ITMALLWGVVYSYFPIVSRFLGDGEIGNFILTFCIGFGGFIGAALVSKWGFNNNRGLT YFTVLSIVSLALFLFTPIFAVSVIAAILFFIAMEYGEVLAKVKVQENAANQIQGRIFS VAEASIGLCISIGSMFINILSAPVIMGLIVVIVCGLFLHTKLVNKSFLERDNKTEQKG VF*" /label="bacE CDS" gene complement(3520602..3521786) /gene="bacE" /locus_tag="BSU_37700" /old_locus_tag="BSU37700" /label="bacE gene" CDS complement(3521783..3523201) /gene="bacD" /locus_tag="BSU_37710" /old_locus_tag="BSU37710" /EC_number="6.3.2.49" /function="16.8: Protect" /function="16.4: Excrete" /experiment="publication(s) with functional evidences, PMID:15609023, 16030213, 18957859, 19061923, 22298000, 22407814, 24702628, 25261512, 25472439, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15609023, 16030213, 18957859, 19061923, 22298000, 22407814, 24702628, 25261512, 25472439, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alanine-anticapsin ligase" /protein_id="NP_391651.1" /db_xref="EnsemblGenomes-Gn:BSU37710" /db_xref="EnsemblGenomes-Tr:CAB15798" /db_xref="GOA:P39641" /db_xref="InterPro:IPR011761" /db_xref="PDB:3VMM" /db_xref="PDB:3WNZ" /db_xref="PDB:3WO0" /db_xref="PDB:3WO1" /db_xref="SubtiList:BG10629" /db_xref="UniProtKB/Swiss-Prot:P39641" /translation="MERKTVLVIADLGGCPPHMFYKSAAEKYNLVSFIPRPFAITASH AALIEKYSVAVIKDKDYFKSLADFEHPDSIYWAHEDHNKPEEEVVEQIVKVAEMFGAD AITTNNELFIAPMAKACERLGLRGAGVQAAENARDKNKMRDAFNKAGVKSIKNKRVTT LEDFRAALEEIGTPLILKPTYLASSIGVTLITDTETAEDEFNRVNDYLKSINVPKAVT FEAPFIAEEFLQGEYGDWYQTEGYSDYISIEGIMADGEYFPIAIHDKTPQIGFTETSH ITPSILDEEAKKKIVEAAKKANEGLGLQNCATHTEIKLMKNREPGLIESAARFAGWNM IPNIKKVFGLDMAQLLLDVLCFGKDADLPDGLLDQEPYYVADCHLYPQHFKQNGQIPE TAEDLVIEAIDIPDGLLKGDTEIVSFSAAAPGTSVDLTLFEAFNSIAAFELKGSNSQD VAESIRQIQQHAKLTAKYVLPV*" /label="bacD CDS" gene complement(3521783..3523201) /gene="bacD" /locus_tag="BSU_37710" /old_locus_tag="BSU37710" /label="bacD gene" CDS complement(3523220..3523981) /gene="bacC" /locus_tag="BSU_37720" /old_locus_tag="BSU37720" /EC_number="1.1.1.385" /function="16.8: Protect" /function="16.4: Excrete" /experiment="publication(s) with functional evidences, PMID:12372825, 15609023, 18957859, 19061923, 23317005, 25261512, 25472439, 26284661, 28158843" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12372825, 15609023, 18957859, 19061923, 23317005, 25261512, 25472439, 26284661, 28158843; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dihydroanticapsin 7-dehydrogenase" /protein_id="NP_391652.2" /db_xref="EnsemblGenomes-Gn:BSU37720" /db_xref="EnsemblGenomes-Tr:CAB15799" /db_xref="GOA:P39640" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="PDB:5ITV" /db_xref="PDB:5ITW" /db_xref="SubtiList:BG10628" /db_xref="UniProtKB/Swiss-Prot:P39640" /translation="MNLTDKTVLITGGASGIGYAAVQAFLGQQANVVVADIDEAQGEA MVRKENNDRLHFVQTDITDEAACQHAVESAVHTFGGLDVLINNAGIEIVAPIHEMELS DWNKVLQVNLTGMFLMSKHALKHMLAAGKGNIINTCSVGGLVAWPDIPAYNASKGGVL QLTKSMAVDYAKHQIRVNCVCPGIIDTPLNEKSFLENNEGTLEEIKKEKAKVNPLLRL GKPEEIANVMLFLASDLSSYMTGSAITADGGYTAQ*" /label="bacC CDS" gene complement(3523220..3523981) /gene="bacC" /locus_tag="BSU_37720" /old_locus_tag="BSU37720" /label="bacC gene" CDS complement(3523984..3524691) /gene="bacB" /locus_tag="BSU_37730" /old_locus_tag="BSU37730" /EC_number="5.3.3.19" /function="16.4: Excrete" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12372825, 14697267, 15609023, 15628860, 18957859, 19061923, 19776011, 20445239, 22483065, 22765234, 25261512, 25472439, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12372825, 14697267, 15609023, 15628860, 18957859, 19061923, 19776011, 20445239, 22483065, 22765234, 25261512, 25472439, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-((4R)-4-hydroxycyclohexa-1, 5-dien-1-yl)-2-oxopropanoate isomerase" /protein_id="NP_391653.1" /db_xref="EnsemblGenomes-Gn:BSU37730" /db_xref="EnsemblGenomes-Tr:CAB15800" /db_xref="GOA:P39639" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR013096" /db_xref="InterPro:IPR014710" /db_xref="PDB:3H7J" /db_xref="PDB:3H7Y" /db_xref="PDB:3H9A" /db_xref="SubtiList:BG10627" /db_xref="UniProtKB/Swiss-Prot:P39639" /translation="MKTKEDMQELYFPTPKLIEWENGVRQYSTVRGDTEVLMSYVPPH TNVEPHQHKEVQIGMVVSGELMMTVGDVTRKMTALESAYIAPPHVPHGARNDTDQEVI AIDIKRLKADETYTSPEDYFLDIFKTRDLLPGMEVTFFVEDWVEIMLAKIPGNGGEMP FHKHRNEQIGICIGGGYDMTVEGCTVEMKFGTAYFCEPREDHGAINRSEKESKSINIF FPPRYNRAKAKKMKADE*" /label="bacB CDS" gene complement(3523984..3524691) /gene="bacB" /locus_tag="BSU_37730" /old_locus_tag="BSU37730" /label="bacB gene" misc_feature complement(3524587..3524588) /Source="Nicolas_upshift_promotors" /id="U2966" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.362637362637363" /psig="0.346653346653347" /xcortree=314 /SigmaFactorBS="cgaaattaattgaatgggaaaacggagtgaggcagtattcaa ccgtacgaggggatactgAAgtattaatgtcttacgtcccgccgcataccaatgttga a" /listShort="bacC, bacD, bacE, bacF" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3524588) /Source="Nicolas_upshifts" /id="U2966" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.362637362637363" /psig="0.346653346653347" /xcortree=314 /SigmaFactorBS="cgaaattaattgaatgggaaaacggagtgaggcagtattcaa ccgtacgaggggatactgAAgtattaatgtcttacgtcccgccgcataccaatgttga a" /listShort="bacC, bacD, bacE, bacF" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3524681..3525295) /gene="bacA" /locus_tag="BSU_37740" /old_locus_tag="BSU37740" /EC_number="4.1.1.100" /function="16.4: Excrete" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:12372825, 15609023, 19776011, 18957859, 19061923, 20052993, 20863139, 25261512, 25472439, 26284661" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12372825, 15609023, 19776011, 18957859, 19061923, 20052993, 20863139, 25261512, 25472439, 26284661; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="prephenate decarboxylase" /protein_id="NP_391654.1" /db_xref="EnsemblGenomes-Gn:BSU37740" /db_xref="EnsemblGenomes-Tr:CAB15801" /db_xref="GOA:P39638" /db_xref="SubtiList:BG10626" /db_xref="UniProtKB/Swiss-Prot:P39638" /translation="MIILDNSIQTKKRTDSLSKLITVNTLGPEGTSSEYAAKHFISNF TLLQGLNSKLSLHDTFESCIERTLQSPLEYTIVPHAYDGIKHFYMRPDLQLLQIFRCD TPMYGLAVRPDFEFRDDMLDTSVIVSHPSPINLIKYFTRKDVRFKLVNSTSQAARKVK EGLYDIALTNELARQKYGLTFVKTFKSIPMSWSLFGKGDVDDEN*" /label="bacA CDS" gene complement(3524681..3525295) /gene="bacA" /locus_tag="BSU_37740" /old_locus_tag="BSU37740" /label="bacA gene" promotor_-35 3524853..3524859 /Source="Nicolas_upshift_promotors" /id="U2967" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=185 /SigmaFactorBS="cttgcggcttgactggttgaattgactAGTTTGAaacgaaca tctttgcGGGTAAAATATTTTATTAAattaataggtgaaggatgtgaaacaataacag a" /listShort="S1459" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3524875..3524893 /Source="Nicolas_upshift_promotors" /id="U2967" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=185 /SigmaFactorBS="cttgcggcttgactggttgaattgactAGTTTGAaacgaaca tctttgcGGGTAAAATATTTTATTAAattaataggtgaaggatgtgaaacaataacag a" /listShort="S1459" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3524886..3525497 /Source="Nicolas_S_feature" /locus_tag="new_3873771_3874382" /HighExp="Etha, Salt, Gly, Heat, C30, LPhT, HiTm, C90, S8, M/G" /AntisenseName="bacA" /AntisenseCor="9.8443047207874598E-2" /AntisenseRegPval="-1" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1459" upshifts 3524886 /Source="Nicolas_upshifts" /id="U2967" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=185 /SigmaFactorBS="cttgcggcttgactggttgaattgactAGTTTGAaacgaaca tctttgcGGGTAAAATATTTTATTAAattaataggtgaaggatgtgaaacaataacag a" /listShort="S1459" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3525318..3525337) /Source="Nicolas_upshift_promotors" /id="U2968" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2947 /SigmaFactorBS="tttgtatgggaataattatcaatattttcaaaaaaCATTGAC AgttcaatttccactGGATAAAATTTACTTAAAATtttaaaagattggttggtgctca t" /listShort="bacA, bacB, bacC, bacD, bacE, bacF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3525334) /Source="Nicolas_upshifts" /id="U2968" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2947 /SigmaFactorBS="tttgtatgggaataattatcaatattttcaaaaaaCATTGAC AgttcaatttccactGGATAAAATTTACTTAAAATtttaaaagattggttggtgctca t" /listShort="bacA, bacB, bacC, bacD, bacE, bacF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3525352..3525359) /Source="Nicolas_upshift_promotors" /id="U2968" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.993006993006993" /psig=1 /xcortree=2947 /SigmaFactorBS="tttgtatgggaataattatcaatattttcaaaaaaCATTGAC AgttcaatttccactGGATAAAATTTACTTAAAATtttaaaagattggttggtgctca t" /listShort="bacA, bacB, bacC, bacD, bacE, bacF" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3525446) /Source="Nicolas_upshifts" /id="D1956" /incds=0 /nref=1 /ntot=33 /MaxReadThrough="2.28302" /MaxDrop="5.44594" /score="19.4538123" /energy="-5.1" /TU="NA" /idTUdmin="U2969" /TUdmin=902 /isTUend="FALSE" /label="downshifts" CDS complement(3525447..3526685) /gene="ywfA" /locus_tag="BSU_37750" /old_locus_tag="BSU37750" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15609023, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_391655.1" /db_xref="EnsemblGenomes-Gn:BSU37750" /db_xref="EnsemblGenomes-Tr:CAB15802" /db_xref="GOA:P39637" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10625" /db_xref="UniProtKB/Swiss-Prot:P39637" /translation="MNSNQNNDIKTKHHFPLLLALALTMGVFAAGSEELVISPLLPDL AKAFSSDVSVLALSISIYGVMIFIGAPLLVPLGDKYSRELSLLAGLMIFIIGTVICAL AQNIFFFFLGRALSGLAAGAFVPTAYAVVGDRVPYTYRGKVMGLIVSSWSLALIFGVP LGSFIGGVLHWRWTFWIFALMGVLVVLLILLEMRRHAQHKNSGKEEIEEPAGTFRDAL KVPRVPVYITITFCNMIGFYGMYSFLGTYLQDVFTGGNTAAGLFIMIYGIGFSMSVIT GKIADRIGKMRSLLIALGVISVLLACLPYAPASMFLLIASLFIWGLMQSLTVTLLSTI LSDCSERHRGKVMVFYSLASNLAVTLGSALMGPVYVAYGYAAVGLICAAITVLGFVLS VFAYKKYGKLEQKADQSLSQ*" /label="ywfA CDS" gene complement(3525447..3526685) /gene="ywfA" /locus_tag="BSU_37750" /old_locus_tag="BSU37750" /label="ywfA gene" promotor_-10 complement(3526727..3526746) /Source="Nicolas_upshift_promotors" /id="U2969" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.72027972027972" /psig="0.988011988011988" /xcortree=756 /SigmaFactorBS="gaaaataataaaacttataaatatttcgttcgaaTTGTAAAT agagaaaaaacAATGCTAAACTATAATACAActttatgataagaagattatggaagag g" /listShort="ywfA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3526739) /Source="Nicolas_upshifts" /id="U2969" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.72027972027972" /psig="0.988011988011988" /xcortree=756 /SigmaFactorBS="gaaaataataaaacttataaatatttcgttcgaaTTGTAAAT agagaaaaaacAATGCTAAACTATAATACAActttatgataagaagattatggaagag g" /listShort="ywfA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3526758..3526765) /Source="Nicolas_upshift_promotors" /id="U2969" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.72027972027972" /psig="0.988011988011988" /xcortree=756 /SigmaFactorBS="gaaaataataaaacttataaatatttcgttcgaaTTGTAAAT agagaaaaaacAATGCTAAACTATAATACAActttatgataagaagattatggaagag g" /listShort="ywfA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3526895..3528307) /gene="rocC" /locus_tag="BSU_37760" /old_locus_tag="BSU37760" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 7540694, 8113162, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="basic aminoacid permease" /protein_id="NP_391656.1" /db_xref="EnsemblGenomes-Gn:BSU37760" /db_xref="EnsemblGenomes-Tr:CAB15803" /db_xref="GOA:P39636" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG10624" /db_xref="UniProtKB/Swiss-Prot:P39636" /translation="MQNHKNELQRSMKSRHLFMIALGGVIGTGLFLGSGFTISQAGPL GAIAAYIIGGFLMYLVMLCLGELAVAMPVAGSFQAYATKFLGQSTGFMIGWLYWFSWA NTVGLELTSAGILMQRWLPSVPIWIWCLVFGIVIFLINALSVRSFAEMEFWFSSIKVA AIILFIVIGGAAVFGLIDFKGGQETPFLSNFMTDRGLFPNGVLAVMFTLVMVNFSFQG TELVGIAAGESESPEKTLPKSIRNVIWRTLFFFVLAMFVLVAILPYKTAGVIESPFVA VLDQIGIPFSADIMNFVILTAILSVANSGLYAASRMMWSLSSNQMGPSFLTRLTKKGV PMNALLITLGISGCSLLTSVMAAETVYLWCISISGMVTVVAWMSICASQFFFRRRFLA EGGNVNDLEFRTPLYPLVPILGFCLYGCVLISLIFIPDQRIGLYCGVPIIIFCYAYYH LSIKKRINHETIEKKQTEAQ*" /label="rocC CDS" gene complement(3526895..3528307) /gene="rocC" /locus_tag="BSU_37760" /old_locus_tag="BSU37760" /label="rocC gene" downshifts complement(3526902) /Source="Nicolas_upshifts" /id="D1957" /incds=0 /nref=16 /ntot=112 /MaxReadThrough="1.06691" /MaxDrop="5.69562" /score="41.626335" /energy="-15.9" /TU="NA" /idTUdmin="U2971" /TUdmin="-4" /isTUend="TRUE" /label="downshifts" CDS complement(3528307..3530007) /gene="rocB" /locus_tag="BSU_37770" /old_locus_tag="BSU37770" /EC_number="3.5.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8113162; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-deacylase involved in arginine and ornithine utilization" /protein_id="NP_391657.1" /db_xref="EnsemblGenomes-Gn:BSU37770" /db_xref="EnsemblGenomes-Tr:CAB15804" /db_xref="GOA:P39635" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR012166" /db_xref="SubtiList:BG10623" /db_xref="UniProtKB/Swiss-Prot:P39635" /translation="MQYTKISHMNPAERVEALTASLVSLSSVNGTVGEGTKADFIKEV ITSYPYFQENPSHVWEQAIPNDPYKRKNIFAFIKGHGESRNTVIYHAHLDTVGIEDFG PLKDIAFDCEKLAEYFSRYEFDQDVQRDAKSGEWMFGRGSVDMQSGIAVHLANLLHFS ENLETLPGNVLFMANPDEESQHSGILASISELNRLKKEKQLHYLAAINTDFITPLYDG DQTRYIYTGAAGKLLPCFYIYGREVHVGDTLAGIDPNFISSEITSRLHNNIHLAEKVE GELVLPPSCLYQRDNKESYNVQTAVSTSLYFNCFIYERTAKEMMDLLIEVTEEACRET EQKLSDYYEEYVKRANLPKKHLSWGIQVYSLEQYLEKLRNRGIDPEQCIEQTFKANEH LELRMRCFQAIEELQKLDPDQGAKVILFYAPPYLPHNYLKEDSARDQLLQHVIKEAAD KTAESTGETFVFKKFFPYLADGSFLSLHETDGEIDSFIRNFPGWNMIGTIPFKDIRKL NIPSINMGVYGKDGHKWTERVYKPYTFHVLPLLIQQTTVHLLQSYRMTITAKEPKGEG *" /label="rocB CDS" gene complement(3528307..3530007) /gene="rocB" /locus_tag="BSU_37770" /old_locus_tag="BSU37770" /label="rocB gene" misc_feature complement(3528976..3528992) /Source="Nicolas_upshift_promotors" /id="U2970" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.238761238761239" /psig="0.613386613386613" /xcortree=2859 /SigmaFactorBS="ggatttgcttattgaagtcactgaggaagcatgccgggagac agaacaaaaattatCAGATTATTACGAAGAAtatgtaaaaagagccaacctgccaaag a" /listShort="rocC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3528988) /Source="Nicolas_upshifts" /id="U2970" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.238761238761239" /psig="0.613386613386613" /xcortree=2859 /SigmaFactorBS="ggatttgcttattgaagtcactgaggaagcatgccgggagac agaacaaaaattatCAGATTATTACGAAGAAtatgtaaaaagagccaacctgccaaag a" /listShort="rocC" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3530081..3531628) /gene="rocA" /locus_tag="BSU_37780" /old_locus_tag="BSU37780" /EC_number="1.2.1.88" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11418582, 12634342, 8113162, 9383188, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="delta-1-pyrroline-5 carboxylate dehydrogenase" /protein_id="NP_391658.1" /db_xref="EnsemblGenomes-Gn:BSU37780" /db_xref="EnsemblGenomes-Tr:CAB15805" /db_xref="GOA:P39634" /db_xref="InterPro:IPR005932" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016160" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="SubtiList:BG10622" /db_xref="UniProtKB/Swiss-Prot:P39634" /translation="MTVTYAHEPFTDFTEAKNKTAFGESLAFVNTQLGKHYPLVINGE KIETDRKIISINPANKEEIIGYASTADQELAEKAMQAALQAFDSWKKQRPEHRANILF KAAAILRRRKHEFSSYLVKEAGKPWKEADADTAEAIDFLEFYARQMLKLKEGAPVKSR AGEVNQYHYEALGVGIVISPFNFPLAIMAGTAVAAIVTGNTILLKPADAAPVVAAKFV EVMEEAGLPNGVLNYIPGDGAEIGDFLVEHPKTRFVSFTGSRAVGCRIYERAAKVQPG QKWLKRVIAEMGGKDTVLVDKDADLDLAASSIVYSAFGYSGQKCSAGSRAVIHQDVYD EVVEKAVALTKTLTVGNPEDPDTYMGPVIHEASYNKVMKYIEIGKSEGKLLAGGEGDD SKGYFIQPTIFADVDENARLMQEEIFGPVVAICKARDFDHMLEIANNTEYGLTGALLT KNRAHIERAREDFHVGNLYFNRGCTGAIVGYQPFGGFNMSGTDSKAGGPDYLILHMQA KTTSEAF*" /label="rocA CDS" gene complement(3530081..3531628) /gene="rocA" /locus_tag="BSU_37780" /old_locus_tag="BSU37780" /label="rocA gene" downshifts complement(3530088) /Source="Nicolas_upshifts" /id="D1958" /incds=0 /nref=4 /ntot=50 /MaxReadThrough="5.60027" /MaxDrop="3.5628" /score="41.626335" /energy="-15.9" /TU="U2971,U2972" /idTUdmin="U2973" /TUdmin=0 /isTUend="TRUE" /label="downshifts" upshifts complement(3531672) /Source="Nicolas_upshifts" /id="U2971" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.874125874125874" /psig="0.874125874125874" /xcortree=2703 /SigmaFactorBS="gttcgattcaacaagttttttcagcaaaagacaagaaaaTGG CATGATTCTTGCATTTttattcatatgcgaagatatatttcataacacgagggggact a" /listShort="rocA, rocB, rocC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3531674..3531854) /Source="Nicolas_S_feature" /locus_tag="new_3880559_3880739_c" /HighExp="S0, Lbstat, T1.30H, T2.0H, T1.0H, BI, T2.30H, M0t90, M40t90, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigL, SigA" /TUshortPSig="0.864, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1460" misc_feature complement(3531675..3531693) /Source="Nicolas_upshift_promotors" /id="U2971" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.874125874125874" /psig="0.874125874125874" /xcortree=2703 /SigmaFactorBS="gttcgattcaacaagttttttcagcaaaagacaagaaaaTGG CATGATTCTTGCATTTttattcatatgcgaagatatatttcataacacgagggggact a" /listShort="rocA, rocB, rocC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(3531855..3533129) /gene="rocG" /locus_tag="BSU_37790" /old_locus_tag="BSU37790" /EC_number="1.4.1.2" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9829940, 10468601, 12634342, 15150224, 17183217, 17608797, 18326565, 20630473, 22178969, 22625175, 25711804, 28193334" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9829940, 10468601, 12634342, 15150224, 17183217, 17608797, 18326565, 20630473, 22178969, 22625175, 25711804, 28193334; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glutamate dehydrogenase" /protein_id="NP_391659.2" /db_xref="EnsemblGenomes-Gn:BSU37790" /db_xref="EnsemblGenomes-Tr:CAB15806" /db_xref="GOA:P39633" /db_xref="InterPro:IPR006095" /db_xref="InterPro:IPR006096" /db_xref="InterPro:IPR006097" /db_xref="InterPro:IPR014362" /db_xref="InterPro:IPR033524" /db_xref="InterPro:IPR033922" /db_xref="InterPro:IPR036291" /db_xref="PDB:3K92" /db_xref="SubtiList:BG10621" /db_xref="UniProtKB/Swiss-Prot:P39633" /translation="MSAKQVSKDEEKEALNLFLSTQTIIKEALRKLGYPGDMYELMKE PQRMLTVRIPVKMDNGSVKVFTGYRSQHNDAVGPTKGGVRFHPEVNEEEVKALSIWMT LKCGIANLPYGGGKGGIICDPRTMSFGELERLSRGYVRAISQIVGPTKDIPAPDVYTN SQIMAWMMDEYSRLREFDSPGFITGKPLVLGGSQGRETATAQGVTICIEEAVKKKGIK LQNARIIIQGFGNAGSFLAKFMHDAGAKVIGISDANGGLYNPDGLDIPYLLDKRDSFG MVTNLFTDVITNEELLEKDCDILVPAAISNQITAKNAHNIQASIVVEAANGPTTIDAT KILNERGVLLVPDILASAGGVTVSYFEWVQNNQGYYWSEEEVAEKLRSVMVSSFETIY QTAATHKVDMRLAAYMTGIRKSAEASRFRGWV*" /label="rocG CDS" gene complement(3531855..3533129) /gene="rocG" /locus_tag="BSU_37790" /old_locus_tag="BSU37790" /label="rocG gene" S_feature complement(3533130..3533212) /Source="Nicolas_S_feature" /locus_tag="new_3882015_3882097_c" /HighExp="S0, Lbstat, T1.30H, T2.0H, T1.0H, BI, T2.30H, M0t90, M40t90, T0.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.83780600000000005" /TUshortSig="SigL, SigA" /TUshortPSig="0.864, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1461" upshifts complement(3533212) /Source="Nicolas_upshifts" /id="U2972" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.864135864135864" /psig="0.864135864135864" /xcortree=393 /SigmaFactorBS="tcagtctctttttttgtggattcaaaagcTGGTACGGATCTT GCATGAtgataagggtgaatccaatgaagaaaggaattggcgggctgattttttaaag c" /listShort="S1461, rocG, S1460, rocA, rocB, rocC" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(3533225..3533243) /Source="Nicolas_upshift_promotors" /id="U2972" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.864135864135864" /psig="0.864135864135864" /xcortree=393 /SigmaFactorBS="tcagtctctttttttgtggattcaaaagcTGGTACGGATCTT GCATGAtgataagggtgaatccaatgaagaaaggaattggcgggctgattttttaaag c" /listShort="S1461, rocG, S1460, rocA, rocB, rocC" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" downshifts complement(3533305) /Source="Nicolas_upshifts" /id="D1959" /incds=0 /nref=9 /ntot=144 /MaxReadThrough="4.82066" /MaxDrop="4.13762" /score="22.6949864" /energy="-11.4" /TU="U2973" /idTUdmin="U2977" /TUdmin=369 /isTUend="FALSE" /label="downshifts" CDS complement(3533306..3533770) /gene="bslB" /locus_tag="BSU_37800" /old_locus_tag="BSU37800" /experiment="publication(s) with functional evidences, PMID:15187182, 28751732" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15187182, 28751732; Product type ph: phenotype" /codon_start=1 /transl_table=11 /product="biofilm protein, member of the processed secretome contributing to biofilm hydrophobicity" /protein_id="NP_391660.1" /db_xref="EnsemblGenomes-Gn:BSU37800" /db_xref="EnsemblGenomes-Tr:CAB15807" /db_xref="GOA:P39632" /db_xref="InterPro:IPR034650" /db_xref="PDB:5MKD" /db_xref="SubtiList:BG10620" /db_xref="UniProtKB/Swiss-Prot:P39632" /translation="MLKRTSFVSSLFISSAVLLSILLPSGQAHAQSASIEAKTVNSTK EWTISDIEVTYKPNAVLSLGAVEFQFPDGFHATTRDSVNGRTLKETQILNDGKTVRLP LTLDLLGASEFDLVMVRKTLPRAGTYTIKGDVVNGLGIGSFYAETQLVIDPR*" /label="bslB CDS" gene complement(3533306..3533770) /gene="bslB" /locus_tag="BSU_37800" /old_locus_tag="BSU37800" /label="bslB gene" S_feature complement(3533771..3533881) /Source="Nicolas_S_feature" /locus_tag="new_3882656_3882766_c" /HighExp="C90, S1, S0, MG 150, M9-tran, LPhT, BI, GM 150, Lbtran, GM 120" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigK" /TUshortPSig="0.999, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1462" promotor_-10 complement(3533863..3533882) /Source="Nicolas_upshift_promotors" /id="U2973" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.964035964035964" /psig="0.999000999001" /xcortree=2719 /SigmaFactorBS="tctcattgaattccaagtgttaatattccttaaaaaaCATTT ACTtccatggaaaatgaTGATAGATTAATTTTTAAGAaaaagaactggtaattcgcga a" /listShort="S1462, yweA, S1461, rocG, S1460, rocA" /listLong="rocB, rocC" /label="promotor_-10" upshifts complement(3533881) /Source="Nicolas_upshifts" /id="U2973" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.964035964035964" /psig="0.999000999001" /xcortree=2719 /SigmaFactorBS="tctcattgaattccaagtgttaatattccttaaaaaaCATTT ACTtccatggaaaatgaTGATAGATTAATTTTTAAGAaaaagaactggtaattcgcga a" /listShort="S1462, yweA, S1461, rocG, S1460, rocA" /listLong="rocB, rocC" /label="upshifts" promotor_-35 complement(3533897..3533904) /Source="Nicolas_upshift_promotors" /id="U2973" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.964035964035964" /psig="0.999000999001" /xcortree=2719 /SigmaFactorBS="tctcattgaattccaagtgttaatattccttaaaaaaCATTT ACTtccatggaaaatgaTGATAGATTAATTTTTAAGAaaaagaactggtaattcgcga a" /listShort="S1462, yweA, S1461, rocG, S1460, rocA" /listLong="rocB, rocC" /label="promotor_-35" downshifts complement(3534092) /Source="Nicolas_upshifts" /id="D1960" /incds=0 /nref=32 /ntot=80 /MaxReadThrough="3.01999" /MaxDrop="4.92444" /score="6.35246869" /energy="-8.4" /TU="U2977" /idTUdmin="U2977" /TUdmin="-418" /isTUend="FALSE" /label="downshifts" CDS complement(3534094..3534549) /gene="spsL" /locus_tag="BSU_37810" /old_locus_tag="BSU37810" /EC_number="5.1.3.13" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 25239894; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dTDP-4-deoxyrhamnose-3,5-epimerase (cell surface and spore coat)" /protein_id="YP_054595.1" /db_xref="EnsemblGenomes-Gn:BSU37810" /db_xref="EnsemblGenomes-Tr:CAE01469" /db_xref="GOA:Q7WY56" /db_xref="InterPro:IPR000888" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014710" /db_xref="SubtiList:BG14195" /db_xref="UniProtKB/Swiss-Prot:Q7WY56" /translation="MIDGVKVKKLMKHSDDRGFFAELVRDDENLLEHFGQASWSKSYP GVIKAFHYHEKQDDLWFFPTGHAQVVLYDLREDSKTKGETDVYYMGEDNPMLLLIPKG VAHGYRVLGETPLTIIYFTTMSYNPDQPDEKRIPWDDETIGFNWNTEFR*" /label="spsL CDS" gene complement(3534094..3534549) /gene="spsL" /locus_tag="BSU_37810" /old_locus_tag="BSU37810" /label="spsL gene" misc_feature 3534184..3534203 /Source="Nicolas_upshift_promotors" /id="U2974" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.671328671328671" /psig=1 /xcortree=2855 /SigmaFactorBS="catcatcccacggaattcttttttcatcaggctgatccgggt tatacgacatGGTGGTAAAATAGATAATTGtcagcggcgtctctcccagcactctata t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3534192 /Source="Nicolas_upshifts" /id="U2974" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.671328671328671" /psig=1 /xcortree=2855 /SigmaFactorBS="catcatcccacggaattcttttttcatcaggctgatccgggt tatacgacatGGTGGTAAAATAGATAATTGtcagcggcgtctctcccagcactctata t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3534542..3535393) /gene="spsK" /locus_tag="BSU_37820" /old_locus_tag="BSU37820" /EC_number="1.1.1.133" /function="16.13: Shape" /function="16.8: Protect" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dTDP-4-dehydrorhamnose reductase" /protein_id="NP_391661.3" /db_xref="EnsemblGenomes-Gn:BSU37820" /db_xref="EnsemblGenomes-Tr:CAB15808" /db_xref="GOA:P39631" /db_xref="InterPro:IPR005913" /db_xref="InterPro:IPR029903" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10619" /db_xref="UniProtKB/Swiss-Prot:P39631" /translation="MTKVLVTGAGGQLGLELCRQLKQAGYEVIALTKKMMNIADQRSV RHSFGHYQPDIVVNSAAFTSVDQCEKELDKAYLINGIGAYYTALESTRIGAQYVHIST DYVFNGKGTQPYREDDPLDPKTIYGKSKRLGEELIRLTTKDSTIIRTSWVYGHGGSNF VETMLKLAETKQELRVVSDQIGSPTYTKDLAEAVIKLFSHPPGIYHVSNSGICSWYEF ATAIMEESGLETAILSVTTEEYGNKTPRPAYSVLSHRAIEEAGIRPRHWREALREYLQ ERSSACD*" /label="spsK CDS" gene complement(3534542..3535393) /gene="spsK" /locus_tag="BSU_37820" /old_locus_tag="BSU37820" /label="spsK gene" CDS complement(3535407..3536354) /gene="spsJ" /locus_tag="BSU_37830" /old_locus_tag="BSU37830" /EC_number="4.2.1.46" /function="16.8: Protect" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:22960854" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22960854; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="dTDP-glucose 4,6-dehydratase" /protein_id="NP_391662.1" /db_xref="EnsemblGenomes-Gn:BSU37830" /db_xref="EnsemblGenomes-Tr:CAB15809" /db_xref="GOA:P39630" /db_xref="InterPro:IPR005888" /db_xref="InterPro:IPR016040" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10618" /db_xref="UniProtKB/Swiss-Prot:P39630" /translation="MAKSYLITGGAGFIGLTFTKLMLRETDARITVLDKLTYASHPEE MEKLKQNSRFRFVKGDISVQEDIDRAFDETYDGVIHFAAESHVDRSISQAEPFITTNV MGTYRLAEAVLKGKAKKLIHISTDEVYGDLKADDPAFTETTPLSPNNPYSASKASSDL LVLSYVKTHKLPAIITRCSNNYGPYQHSEKMIPTIIRHAKQGLPVPLYGDGLQIRDWL FAEDHCRAIKLILEKGTDGEVYNIGGGNERTNKELASVILKHLGCEELFAHVEDRKGH DRRYAINASKLKNELGWRQEVTFEEGIARTIQWYTDNDR*" /label="spsJ CDS" gene complement(3535407..3536354) /gene="spsJ" /locus_tag="BSU_37830" /old_locus_tag="BSU37830" /label="spsJ gene" CDS complement(3536354..3537094) /gene="spsI" /locus_tag="BSU_37840" /old_locus_tag="BSU37840" /EC_number="2.7.7.24" /function="16.8: Protect" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:22960854" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22960854; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glucose-1-phosphate thymidylyltransferase" /protein_id="NP_391663.1" /db_xref="EnsemblGenomes-Gn:BSU37840" /db_xref="EnsemblGenomes-Tr:CAB15810" /db_xref="GOA:P39629" /db_xref="InterPro:IPR005835" /db_xref="InterPro:IPR005907" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG10617" /db_xref="UniProtKB/Swiss-Prot:P39629" /translation="MKGVILAGGNGSRLMPLTKAVNKHLLPVGPYPMIYWSIMKLQEA GIKDILLISQKEHMPQFYKLLGNGEELGVTITYQVQPAASGISDGLSYAKRFTKKESF ILLLGDNIFEDSLKPYTERFEQQGKGAKVLLKEVDDPERFGIAEIDEKNKRIRSIIEK PEQPPTNLCVTGIYMYDAEVFSYIEQISPSKRGELEITDVNNLYIENSQLTYDVLSGW WVDAGTHESLYLASQLVHQALRKGQDEK*" /label="spsI CDS" gene complement(3536354..3537094) /gene="spsI" /locus_tag="BSU_37840" /old_locus_tag="BSU37840" /label="spsI gene" promotor_-35 3537112..3537117 /Source="Nicolas_upshift_promotors" /id="U2975" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.89010989010989" /psig="0.89010989010989" /xcortree=953 /SigmaFactorBS="gtgagccgtttcctccggctaaaataacacctttcacattaa cacttccttacaTGCATTtttatatctcttgtTCATATAAATCTTGAAGAAtagctgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3537118 /Source="Nicolas_upshifts" /id="U2975" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.89010989010989" /psig="0.89010989010989" /xcortree=953 /SigmaFactorBS="gtgagccgtttcctccggctaaaataacacctttcacattaa cacttccttacaTGCATTtttatatctcttgtTCATATAAATCTTGAAGAAtagctgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3537119..3538138) /gene="spsG" /locus_tag="BSU_37850" /old_locus_tag="BSU37850" /function="16.13: Shape" /function="16.8: Protect" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_391664.1" /db_xref="EnsemblGenomes-Gn:BSU37850" /db_xref="EnsemblGenomes-Tr:CAB15811" /db_xref="GOA:P39627" /db_xref="InterPro:IPR007235" /db_xref="SubtiList:BG10615" /db_xref="UniProtKB/Swiss-Prot:P39627" /translation="MHVGIFADGGYEKGMGHVVRMKRLAEGLKQRCLITFYTNQDSEA FLHEEHWQVIVKPELQQHEFILREIKSKKLDLLLFDILGAPAELLKKIKTETDAKIVL FEEKNGKSIQYSDAVINGIYGDIRSRVYVQGNTRIYEGPDYLILHPAFQAAREDYTLK KDCRNILVALGGSDPKQLIFKVLAAADQVPDIKDKNMMFVMGSASPHQEAVRRRIEKK PQYKMIEQTNDMAGLMKQADAAIVAGGISLYEAICIGVPCLVLSQVEHQTATAKTFAD QGAALDLGLGELVPDETLIYQMSRIMSSYPLRLSLHKGGRPLVDGKGIIRVTAILQDL YEQEI*" /label="spsG CDS" gene complement(3537119..3538138) /gene="spsG" /locus_tag="BSU_37850" /old_locus_tag="BSU37850" /label="spsG gene" promotor_-10 3537132..3537150 /Source="Nicolas_upshift_promotors" /id="U2975" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.89010989010989" /psig="0.89010989010989" /xcortree=953 /SigmaFactorBS="gtgagccgtttcctccggctaaaataacacctttcacattaa cacttccttacaTGCATTtttatatctcttgtTCATATAAATCTTGAAGAAtagctgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 3538002..3538011 /Source="Nicolas_upshift_promotors" /id="U2976" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1682 /SigmaFactorBS="acgatgacctgccaatgctcttcatgaAGAAACGCTTcagaa tcctgatTCGTATAAAACGTAATcaagcatcgctgtttgagcccctccgcaagcctct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3538024..3538039 /Source="Nicolas_upshift_promotors" /id="U2976" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1682 /SigmaFactorBS="acgatgacctgccaatgctcttcatgaAGAAACGCTTcagaa tcctgatTCGTATAAAACGTAATcaagcatcgctgtttgagcccctccgcaagcctct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3538035 /Source="Nicolas_upshifts" /id="U2976" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1682 /SigmaFactorBS="acgatgacctgccaatgctcttcatgaAGAAACGCTTcagaa tcctgatTCGTATAAAACGTAATcaagcatcgctgtttgagcccctccgcaagcctct t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3538141..3538863) /gene="spsF" /locus_tag="BSU_37860" /old_locus_tag="BSU37860" /EC_number="2.-.-.-" /function="16.8: Protect" /function="16.5: Explore" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_391665.2" /db_xref="EnsemblGenomes-Gn:BSU37860" /db_xref="EnsemblGenomes-Tr:CAB15812" /db_xref="InterPro:IPR003329" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG10614" /db_xref="UniProtKB/Swiss-Prot:P39626" /translation="MNDILFIIQARMGSTRLPGKVLRPLGSNRLLDILVHRVRQSAFY QKDRDNLVIATSDKETDDILEAHCIKQGFRVFRGSEERVLDRFVKVIEAVKPSVIIRL TGDNPFVDPELLDVMIQAHFDQGSDYTYILNAPLGICGEVVNANLLIDISRIQALEDQ YQEHVTLYIRNHPALYRVQFLEAPERFRAPQYRLTIDTKEDYESIKALYQKAGERPDV SASELITLLNRNPDAATEREAD*" /label="spsF CDS" gene complement(3538141..3538863) /gene="spsF" /locus_tag="BSU_37860" /old_locus_tag="BSU37860" /label="spsF gene" CDS complement(3538856..3539977) /gene="spsE" /locus_tag="BSU_37870" /old_locus_tag="BSU37870" /EC_number="2.5.-.-" /function="16.13: Shape" /function="16.8: Protect" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12597896, 15774001; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphoenolpyruvate-sugar pyruvyltransferase" /protein_id="NP_391666.1" /db_xref="EnsemblGenomes-Gn:BSU37870" /db_xref="EnsemblGenomes-Tr:CAB15813" /db_xref="GOA:P39625" /db_xref="InterPro:IPR006190" /db_xref="InterPro:IPR013132" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR013974" /db_xref="InterPro:IPR036732" /db_xref="PDB:1VLI" /db_xref="SubtiList:BG10613" /db_xref="UniProtKB/Swiss-Prot:P39625" /translation="MAAFQIANKTVGKDAPVFIIAEAGINHDGKLDQAFALIDAAAEA GADAVKFQMFQADRMYQKDPGLYKTAAGKDVSIFSLVQSMEMPAEWILPLLDYCREKQ VIFLSTVCDEGSADLLQSTSPSAFKIASYEINHLPLLKYVARLNRPMIFSTAGAEISD VHEAWRTIRAEGNNQIAIMHCVAKYPAPPEYSNLSVIPMLAAAFPEAVIGFSDHSEHP TEAPCAAVRLGAKLIEKHFTIDKNLPGADHSFALNPDELKEMVDGIRKTEAELKQGIT KPVSEKLLGSSYKTTTAIEGEIRNFAYRGIFTTAPIQKGEAFSEDNIAVLRPGQKPQG LHPRFFELLTSGVRAVRDIPADTGIVWDDILLKDSPFHE*" /label="spsE CDS" gene complement(3538856..3539977) /gene="spsE" /locus_tag="BSU_37870" /old_locus_tag="BSU37870" /label="spsE gene" CDS complement(3539977..3540846) /gene="spsD" /locus_tag="BSU_37880" /old_locus_tag="BSU37880" /EC_number="2.3.1.-" /function="16.5: Explore" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative TDP-glycosamine N-acetyltransferase" /protein_id="NP_391667.1" /db_xref="EnsemblGenomes-Gn:BSU37880" /db_xref="EnsemblGenomes-Tr:CAB15814" /db_xref="GOA:P39624" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG10612" /db_xref="UniProtKB/Swiss-Prot:P39624" /translation="MYTVKENVSKEAIEEFLQSRKLTLDVPYQFSLGLFENSRLQGVL LYEDSLWESKVLQKKVMNVKLLAANSTGQLKRLFEAFYTVRQMDETDFIFVRVPAEDI GAAHVIQQQPSSYFVGSLLKLAMPPSFYDKTPPFFELGPPEPGDTEAICELARDSFTK SRYFQDPHLSRDAANEIFQEWTRNNLNGRAAVNIVAKHNGEVIGYLQGLSRDDECILD LMAVKPGFEGKRIAFHLLANLIEQPETQKHRTVTAGTQLHNVRAIRLYERMGFTAEQS YYYYHIWPGKEAK*" /label="spsD CDS" gene complement(3539977..3540846) /gene="spsD" /locus_tag="BSU_37880" /old_locus_tag="BSU37880" /label="spsD gene" CDS complement(3540847..3542016) /gene="spsC" /locus_tag="BSU_37890" /old_locus_tag="BSU37890" /EC_number="2.6.1.-" /function="16.8: Protect" /function="16.13: Shape" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14602648; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glutamine-dependent sugar transaminase" /protein_id="NP_391668.1" /db_xref="EnsemblGenomes-Gn:BSU37890" /db_xref="EnsemblGenomes-Tr:CAB15815" /db_xref="GOA:P39623" /db_xref="InterPro:IPR000653" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="SubtiList:BG10611" /db_xref="UniProtKB/Swiss-Prot:P39623" /translation="MVQKRNHFLPYSLPLIGKEEIQEVTETLESGWLSKGPKVQQFEK EFAAFVGAKHAVAVNSCTAALFLALKAKGIGPGDEVITSPLTFSSTANTIIHTGATPV FADIDENTLNIDPVKLEAAVTPRTKAVVPVHFGGQSCDMDAILAVAQNHGLFVLEDAA HAVYTTYKQRMIGSIGDATAFSFYATKNLATGEGGMLTTDDEELADKIRVLSLHGMSK AAWNRYSSNGSWYYEVESPGYKMNMFDLQAALGLHQLKRLDDMQKRREEIAGRYQTAF QQIPGLITPFVHDDGRHAWHLYVLQVDEKKAGVTRSEMITALKDEYNIGTSVHFIPVH IHPYYQKQFGYKEADFPNAMNYYKRTLSLPLYPSMSDDDVDDVIEAVRDIVKGAD*" /label="spsC CDS" gene complement(3540847..3542016) /gene="spsC" /locus_tag="BSU_37890" /old_locus_tag="BSU37890" /label="spsC gene" CDS complement(3542037..3543461) /gene="spsB" /locus_tag="BSU_37900" /old_locus_tag="BSU37900" /function="16.5: Explore" /function="16.8: Protect" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22611084; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dTDP glycosyl/glycerophosphate transferase or transport" /protein_id="NP_391669.2" /db_xref="EnsemblGenomes-Gn:BSU37900" /db_xref="EnsemblGenomes-Tr:CAB15816" /db_xref="GOA:P39622" /db_xref="InterPro:IPR007554" /db_xref="SubtiList:BG10610" /db_xref="UniProtKB/Swiss-Prot:P39622" /translation="MSAYLSNYWVLYRKYVELFDKLRYKGIPLGLISNFYQYISPELR VMMEEEPELFGSVDQHIDEGQIQPFFEERIQNIVKTNDEPVKGKVILHFDYLRFSNEN YYQFDPEKTAVLARWSLPHYCDLPVISKREIADSCQKGDSKQYLETACSLLAPYDDHP AFGDQAFRDRLFKDIPLFIEAIDTVDALFEQEKISAVIVGTAEDIYSRVLALMCQRKG AVSICLQHGALMGDEAFIPVFTTYQAVFGAYEAEWFIRKGCKPEQILVTGHPRFDQIF NRTPMDMSIFYRKLAFQPTKKIVLIATQPFSEDFYSGVLQGLSDQKQLQIIIKPHPWE IGKNKLDLYHEAAKKHQACRVIKKELELYDLLPYVDAAVTQTSTVGLEAMLFQKPVLI GKSSGNRSYPYYESLGDFMFDQPDELAHTLVEVLRSPDVHQKAEEARLAFIAANYPVA ESTNALFAELKAKTGVDYRREDTE*" /label="spsB CDS" gene complement(3542037..3543461) /gene="spsB" /locus_tag="BSU_37900" /old_locus_tag="BSU37900" /label="spsB gene" CDS complement(3543466..3544236) /gene="spsA" /locus_tag="BSU_37910" /old_locus_tag="BSU37910" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:10350455, 11042447, 11733986" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10350455, 11042447, 11733986; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="spore coat dTDP-glycosyltransferase" /protein_id="NP_391670.1" /db_xref="EnsemblGenomes-Gn:BSU37910" /db_xref="EnsemblGenomes-Tr:CAB15817" /db_xref="GOA:P39621" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="PDB:1H7L" /db_xref="PDB:1H7Q" /db_xref="PDB:1QG8" /db_xref="PDB:1QGQ" /db_xref="PDB:1QGS" /db_xref="SubtiList:BG10609" /db_xref="UniProtKB/Swiss-Prot:P39621" /translation="MPKVSVIMTSYNKSDYVAKSISSILSQTFSDFELFIMDDNSNEE TLNVIRPFLNDNRVRFYQSDISGVKERTEKTRYAALINQAIEMAEGEYITYATDDNIY MPDRLLKMVRELDTHPEKAVIYSASKTYHLNENRDIVKETVRPAAQVTWNAPCAIDHC SVMHRYSVLEKVKEKFGSYWDESPAFYRIGDARFFWRVNHFYPFYPLDEELDLNYITD QSIHFQLFELEKNEFVRNLPPQRNCRELRESLKKLGMG*" /label="spsA CDS" gene complement(3543466..3544236) /gene="spsA" /locus_tag="BSU_37910" /old_locus_tag="BSU37910" /label="spsA gene" promotor_-10 complement(3544271..3544290) /Source="Nicolas_upshift_promotors" /id="U2977" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1357 /SigmaFactorBS="atacacaaacttttcgcatattggtttgtatcCCTAGCGCAA cttgagcataagcAACATAAGATAACGATAGTTtcaggtgtgaagttccaagaaggag g" /listShort="spsA, spsB, spsC, spsD, spsE, spsF, spsG, spsI, spsJ, spsK, spsL, S1462, yweA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3544285) /Source="Nicolas_upshifts" /id="U2977" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1357 /SigmaFactorBS="atacacaaacttttcgcatattggtttgtatcCCTAGCGCAA cttgagcataagcAACATAAGATAACGATAGTTtcaggtgtgaagttccaagaaggag g" /listShort="spsA, spsB, spsC, spsD, spsE, spsF, spsG, spsI, spsJ, spsK, spsL, S1462, yweA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3544304..3544313) /Source="Nicolas_upshift_promotors" /id="U2977" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1357 /SigmaFactorBS="atacacaaacttttcgcatattggtttgtatcCCTAGCGCAA cttgagcataagcAACATAAGATAACGATAGTTtcaggtgtgaagttccaagaaggag g" /listShort="spsA, spsB, spsC, spsD, spsE, spsF, spsG, spsI, spsJ, spsK, spsL, S1462, yweA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3544404..3544409 /Source="Nicolas_upshift_promotors" /id="U2978" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1093 /SigmaFactorBS="cccagagcgaaatctgatcggtccgctgttctttttcAGCAT AatccaagcatcagccTCATAAGGTGAAAGAGATAaaaatcgcaccagcgactaagat c" /listShort="S1463, ywdL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3544425..3544443 /Source="Nicolas_upshift_promotors" /id="U2978" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1093 /SigmaFactorBS="cccagagcgaaatctgatcggtccgctgttctttttcAGCAT AatccaagcatcagccTCATAAGGTGAAAGAGATAaaaatcgcaccagcgactaagat c" /listShort="S1463, ywdL" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3544427..3544555 /Source="Nicolas_S_feature" /locus_tag="new_3893312_3893440" /HighExp="S5, S4, S3, S7, B36, S8, S6, B60, T5.0H, G/S" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1463" upshifts 3544427 /Source="Nicolas_upshifts" /id="U2978" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1093 /SigmaFactorBS="cccagagcgaaatctgatcggtccgctgttctttttcAGCAT AatccaagcatcagccTCATAAGGTGAAAGAGATAaaaatcgcaccagcgactaagat c" /listShort="S1463, ywdL" /GFF_Attribute="listLong" /label="upshifts" CDS 3544556..3545101 /gene="gerQ" /locus_tag="BSU_37920" /old_locus_tag="BSU37920" /function="16.8: Protect" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:12644503, 15317760, 16936016, 16936016, 19933362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12644503, 15317760, 16936016, 16936016, 19933362; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="inner spore coat protein" /protein_id="NP_391671.1" /db_xref="EnsemblGenomes-Gn:BSU37920" /db_xref="EnsemblGenomes-Tr:CAB15818" /db_xref="GOA:P39620" /db_xref="InterPro:IPR014099" /db_xref="SubtiList:BG10608" /db_xref="UniProtKB/Swiss-Prot:P39620" /translation="MKPKKNQYQQMQAFDNMQGYQPQFGANPYPQQGQGSQMQTMGMQ PMMPMQQGQQGQQGQQGFGFPGQQQGGGFQIPSGPTPSGPGQSVPGMLPVEESYIENI LRLNRGKTATIYMTFENSKEWGSKIFRGVIEAAGRDHIIISDPKSGTRYLLLTIYLDY ITFDEEIAYTYPYSMASYSPR*" /label="gerQ CDS" gene 3544556..3545101 /gene="gerQ" /locus_tag="BSU_37920" /old_locus_tag="BSU37920" /label="gerQ gene" downshifts 3545087 /Source="Nicolas_upshifts" /id="D1961" /incds=0 /nref=60 /ntot=77 /MaxReadThrough="1.98659" /MaxDrop="7.96105" /score="16.9179802" /energy="-11.7" /TU="NA" /idTUdmin="U2978" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3545145..3545516) /gene="ywdK" /locus_tag="BSU_37930" /old_locus_tag="BSU37930" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 15919996, 21810204; Product type m:membrane component" /codon_start=1 /transl_table=11 /product="conserved membrane protein" /protein_id="NP_391672.2" /db_xref="EnsemblGenomes-Gn:BSU37930" /db_xref="EnsemblGenomes-Tr:CAB15819" /db_xref="GOA:P39619" /db_xref="InterPro:IPR006696" /db_xref="SubtiList:BG10607" /db_xref="UniProtKB/Swiss-Prot:P39619" /translation="MKVFIILGAINALLAVGLGAFGAHGLEGKIPDKYLQVWHTGVQY HMYHALGLFVVAFLADKLSGIGSVTTAGWLMFAGIVLFSGSLYILSVTQISILGAITP LGGVAFIISWIMIVVAAVKYL*" /label="ywdK CDS" gene complement(3545145..3545516) /gene="ywdK" /locus_tag="BSU_37930" /old_locus_tag="BSU37930" /label="ywdK gene" downshifts complement(3545163) /Source="Nicolas_upshifts" /id="D1962" /incds=0 /nref=134 /ntot=227 /MaxReadThrough="3.65585" /MaxDrop="4.84049" /score="15.105437" /energy="-11.7" /TU="NA" /idTUdmin="U2979" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3545578..3546900) /gene="ywdJ" /locus_tag="BSU_37940" /old_locus_tag="BSU37940" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative purine/pyrimidine permease" /protein_id="NP_391673.2" /db_xref="EnsemblGenomes-Gn:BSU37940" /db_xref="EnsemblGenomes-Tr:CAB15820" /db_xref="GOA:P39618" /db_xref="InterPro:IPR006042" /db_xref="InterPro:IPR006043" /db_xref="SubtiList:BG10606" /db_xref="UniProtKB/Swiss-Prot:P39618" /translation="MKLVLGALQWTAFIIAAAIVVPVAVAQSFHLDHSDSARLIQSTF FVLGIAAVIQCLKGHRLPINESPAGLWWGVYTIYAGLTGTVFATYGDTLRGLQGALLV SAVCFFLLSVFKVIDRLAKLFTPVVTGVYLLLLVMQLSQPIIKGILGIGYRQDGVDGL VFGLALVVIAAAFIMTNSNIMFFKQYSILLALFGGWVLFAAAGAAKPIEMPDRLFQLP SLFPFGTPLFNSGLIITSIFITILLIVNMLASMKVVDIAMKKFSKQPDGKHHERHAGF AASFSHLLSGLTGAIAPVPISGAAGFIETTKMPSKKPFMLGSILVIVISVIPFFMNTF ASLPSPVGFAVNFVVFSAMGGLAFAEFDSYEKEESKRVRSIIGISLLTGVGIMFVPET ALKGLHPVFISLLSNGLVLGTLAAIAADQFQLWRRRKSDNLVSTENKH*" /label="ywdJ CDS" gene complement(3545578..3546900) /gene="ywdJ" /locus_tag="BSU_37940" /old_locus_tag="BSU37940" /label="ywdJ gene" CDS complement(3546920..3547237) /gene="ywdI" /locus_tag="BSU_37950" /old_locus_tag="BSU37950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391674.3" /db_xref="EnsemblGenomes-Gn:BSU37950" /db_xref="EnsemblGenomes-Tr:CAB15821" /db_xref="InterPro:IPR035218" /db_xref="SubtiList:BG10605" /db_xref="UniProtKB/Swiss-Prot:P39617" /translation="MNIHISALIQKMEEELKKAKTAERDEELKRYVAVVRSLCDVVLD QPENASAPRIQPSVTPSPAAPPSTDQLMMEKMMGSAGLNKYRKQEKEKQEEDGNGESL FDF*" /label="ywdI CDS" gene complement(3546920..3547237) /gene="ywdI" /locus_tag="BSU_37950" /old_locus_tag="BSU37950" /label="ywdI gene" promotor_-10 complement(3547266..3547285) /Source="Nicolas_upshift_promotors" /id="U2979" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.517482517482518" /psig=1 /xcortree=1928 /SigmaFactorBS="gcaaggtttgtcagaaaaaataacaaactcatATCTGCGttt tcagcaggaaTTTGATAAAATGCAGGAAGAcaacatttatttttttggagggtgcttc a" /listShort="ywdI, ywdJ, ywdK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3547277) /Source="Nicolas_upshifts" /id="U2979" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.517482517482518" /psig=1 /xcortree=1928 /SigmaFactorBS="gcaaggtttgtcagaaaaaataacaaactcatATCTGCGttt tcagcaggaaTTTGATAAAATGCAGGAAGAcaacatttatttttttggagggtgcttc a" /listShort="ywdI, ywdJ, ywdK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3547299..3547305) /Source="Nicolas_upshift_promotors" /id="U2979" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.517482517482518" /psig=1 /xcortree=1928 /SigmaFactorBS="gcaaggtttgtcagaaaaaataacaaactcatATCTGCGttt tcagcaggaaTTTGATAAAATGCAGGAAGAcaacatttatttttttggagggtgcttc a" /listShort="ywdI, ywdJ, ywdK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3547340..3547347 /Source="Nicolas_upshift_promotors" /id="U2980" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.52947052947053" /psig="0.988011988011988" /xcortree=1868 /SigmaFactorBS="atgagtttgttattttttctgacaaaccttgcgcGATTGACA agcagaagagattttTCACATAATAAATCACCATAccttacaaaaaggagaaacggaa t" /listShort="ywdH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3547363..3547382 /Source="Nicolas_upshift_promotors" /id="U2980" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.52947052947053" /psig="0.988011988011988" /xcortree=1868 /SigmaFactorBS="atgagtttgttattttttctgacaaaccttgcgcGATTGACA agcagaagagattttTCACATAATAAATCACCATAccttacaaaaaggagaaacggaa t" /listShort="ywdH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3547366 /Source="Nicolas_upshifts" /id="U2980" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.52947052947053" /psig="0.988011988011988" /xcortree=1868 /SigmaFactorBS="atgagtttgttattttttctgacaaaccttgcgcGATTGACA agcagaagagattttTCACATAATAAATCACCATAccttacaaaaaggagaaacggaa t" /listShort="ywdH" /GFF_Attribute="listLong" /label="upshifts" CDS 3547405..3548775 /gene="ywdH" /locus_tag="BSU_37960" /old_locus_tag="BSU37960" /EC_number="1.2.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aldehyde dehydrogenase" /protein_id="NP_391675.2" /db_xref="EnsemblGenomes-Gn:BSU37960" /db_xref="EnsemblGenomes-Tr:CAB15822" /db_xref="GOA:P39616" /db_xref="InterPro:IPR012394" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016160" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="SubtiList:BG10604" /db_xref="UniProtKB/Swiss-Prot:P39616" /translation="MNSIPSIISKHKAYFAAGHTRPLESRLNILRKLKQAVRTHEADL IAALYQDLHKSEQEAYSTEIGIVLEEISFVMKRLRKWSKPKRVKTPLTHLGSKSIIIP EPYGTVLVIAPWNYPLQLALSPLIGAIAAGNTVVLKPSEYTPAVSAILSKLISSVFPT DYVAMAEGGPDVSTALLQQPFDYIFFTGSVAVGKIVMEAAAKQLIPVTLELGGKSPCI VHKDADIQLAAKRIVFGKFTNAGQTCIAPDYLFVHEDIKTKLTEEMKRAIREFYGPQP ERNPQYGKIVSERHYQRLLSFLNDGIPLTGGQSDPNHHKIAPTILEQVRDDSPVMQEE IFGPILPLFTYRNIGEVIEKVQSRPKPLALYLFTTNKEIERAVLGNLSFGGGCVNDTL MHVATPYLPFGGVGESGIGSYHGFDSFNTFTHKKSVVKQTNRFDFAFRYPSSKNGLRM IRKILK*" /label="ywdH CDS" gene 3547405..3548775 /gene="ywdH" /locus_tag="BSU_37960" /old_locus_tag="BSU37960" /label="ywdH gene" CDS complement(3548800..3549477) /gene="ung" /locus_tag="BSU_37970" /old_locus_tag="BSU37970" /EC_number="3.2.2.27" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:1902430, 9776748, 10080896, 21542855, 22056936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1902430, 9776748, 10080896, 21542855, 22056936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="uracil-DNA glycosylase" /protein_id="NP_391676.1" /db_xref="EnsemblGenomes-Gn:BSU37970" /db_xref="EnsemblGenomes-Tr:CAB15823" /db_xref="GOA:P39615" /db_xref="InterPro:IPR002043" /db_xref="InterPro:IPR005122" /db_xref="InterPro:IPR018085" /db_xref="InterPro:IPR036895" /db_xref="PDB:3ZOQ" /db_xref="PDB:3ZOR" /db_xref="SubtiList:BG10603" /db_xref="UniProtKB/Swiss-Prot:P39615" /translation="MKQLLQDSWWNQLKEEFEKPYYQELREMLKREYAEQTIYPDSRD IFNALHYTSYDDVKVVILGQDPYHGPGQAQGLSFSVKPGVKQPPSLKNIFLELQQDIG CSIPNHGSLVSWAKQGVLLLNTVLTVRRGQANSHKGKGWERLTDRIIDVLSERERPVI FILWGRHAQMKKERIDTSKHFIIESTHPSPFSARNGFFGSRPFSRANAYLEKMGEAPI DWCIKDL*" /label="ung CDS" gene complement(3548800..3549477) /gene="ung" /locus_tag="BSU_37970" /old_locus_tag="BSU37970" /label="ung gene" downshifts complement(3548814) /Source="Nicolas_upshifts" /id="D1963" /incds=0 /nref=66 /ntot=224 /MaxReadThrough="2.25259" /MaxDrop="4.72154" /score="26.8023311" /energy="-9.1" /TU="NA" /idTUdmin="U2982" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3549304..3549323) /Source="Nicolas_upshift_promotors" /id="U2981" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.425574425574426" /psig="0.837162837162837" /xcortree=1736 /SigmaFactorBS="acgcggagcaaacgatttatccggacagccgggataTTTTCA acgcgctgcattataCATCATATGATGATGTCAAGgtcgtcattttgggtcaagatcc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3549320) /Source="Nicolas_upshifts" /id="U2981" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.425574425574426" /psig="0.837162837162837" /xcortree=1736 /SigmaFactorBS="acgcggagcaaacgatttatccggacagccgggataTTTTCA acgcgctgcattataCATCATATGATGATGTCAAGgtcgtcattttgggtcaagatcc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3549339..3549344) /Source="Nicolas_upshift_promotors" /id="U2981" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.425574425574426" /psig="0.837162837162837" /xcortree=1736 /SigmaFactorBS="acgcggagcaaacgatttatccggacagccgggataTTTTCA acgcgctgcattataCATCATATGATGATGTCAAGgtcgtcattttgggtcaagatcc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3549491..3550297) /gene="ywdF" /locus_tag="BSU_37980" /old_locus_tag="BSU37980" /EC_number="2.4.-.-" /function="16.13: Shape" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9334165; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyltransferase" /protein_id="NP_391677.1" /db_xref="EnsemblGenomes-Gn:BSU37980" /db_xref="EnsemblGenomes-Tr:CAB15824" /db_xref="GOA:P39614" /db_xref="InterPro:IPR001173" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG10602" /db_xref="UniProtKB/Swiss-Prot:P39614" /translation="MKISIVIVTYNRIPALCELLESISRQTLMPYEIIIVNDAGESVV PVKALYPELPIAVINLEKNSGHVAARNAGVKEASGDCIMLCDDDDFFTPGHIEKMAKE IETADFVHSDAEIVSFEEKNGTRYPVSRKLFAYTADYEDMRVFSTYVPSGSMYRRFLH DEIGYFDADVHNYWDWDFYLRAAKDYRVKRVPCASVIYAFSDAGDNQSADLGAKRKQY LDRLSEKHGLGELPTKNFAVLLEEPEMKRREAKSEMVWDGEPVYSRLHRS*" /label="ywdF CDS" gene complement(3549491..3550297) /gene="ywdF" /locus_tag="BSU_37980" /old_locus_tag="BSU37980" /label="ywdF gene" promotor_-10 complement(3549790..3549808) /Source="Nicolas_upshift_promotors" /id="U2982" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=139 /SigmaFactorBS="tttctacatacgtgccgtcgggcagcatgtacagaCGTTTTC tgcatgatgaaatcGGGTATTTCGATGCTGATGtgcacaattactgggactgggattt t" /listShort="ung" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3549804) /Source="Nicolas_upshifts" /id="U2982" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=139 /SigmaFactorBS="tttctacatacgtgccgtcgggcagcatgtacagaCGTTTTC tgcatgatgaaatcGGGTATTTCGATGCTGATGtgcacaattactgggactgggattt t" /listShort="ung" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3549823..3549829) /Source="Nicolas_upshift_promotors" /id="U2982" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=139 /SigmaFactorBS="tttctacatacgtgccgtcgggcagcatgtacagaCGTTTTC tgcatgatgaaatcGGGTATTTCGATGCTGATGtgcacaattactgggactgggattt t" /listShort="ung" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3550326..3550345) /Source="Nicolas_upshift_promotors" /id="U2983" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.612387612387612" /psig="0.996003996003996" /xcortree=2559 /SigmaFactorBS="ttgtagtatgccgtttcagtaggaTATTCCCActgatctccc gtccaATATATGTTTTAATAGTACAtgactatgaaaatgagaaggagagcatcatgaa g" /listShort="ywdF, ung" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3550332) /Source="Nicolas_upshifts" /id="U2983" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.612387612387612" /psig="0.996003996003996" /xcortree=2559 /SigmaFactorBS="ttgtagtatgccgtttcagtaggaTATTCCCActgatctccc gtccaATATATGTTTTAATAGTACAtgactatgaaaatgagaaggagagcatcatgaa g" /listShort="ywdF, ung" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3550361..3550368) /Source="Nicolas_upshift_promotors" /id="U2983" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.612387612387612" /psig="0.996003996003996" /xcortree=2559 /SigmaFactorBS="ttgtagtatgccgtttcagtaggaTATTCCCActgatctccc gtccaATATATGTTTTAATAGTACAtgactatgaaaatgagaaggagagcatcatgaa g" /listShort="ywdF, ung" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3550387..3550920) /gene="ywdE" /locus_tag="BSU_37990" /old_locus_tag="BSU37990" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein of unknown function" /protein_id="NP_391678.1" /db_xref="EnsemblGenomes-Gn:BSU37990" /db_xref="EnsemblGenomes-Tr:CAB15825" /db_xref="GOA:P39613" /db_xref="SubtiList:BG10601" /db_xref="UniProtKB/Swiss-Prot:P39613" /translation="MRISSCLYGFVAHGAVFLFTGGCMLLAMAASLPFVFLLDRLPDV VFTAGAILTLLCSYAYVWFWAVRFAYNQKMRLFEVQLGSFVLLALMISLFLLDGSSMK DIMMNWDDAGCAFVPPAFTFLCLSYALVLLPVYQSKLWRLILPNGVRMKDIFHVFGDL MLIMVLLIGATLLFLSL*" /label="ywdE CDS" gene complement(3550387..3550920) /gene="ywdE" /locus_tag="BSU_37990" /old_locus_tag="BSU37990" /label="ywdE gene" CDS complement(3550968..3551603) /gene="ywdD" /locus_tag="BSU_38000" /old_locus_tag="BSU38000" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein of unknown function" /protein_id="NP_391679.2" /db_xref="EnsemblGenomes-Gn:BSU38000" /db_xref="EnsemblGenomes-Tr:CAB15826" /db_xref="GOA:P39612" /db_xref="SubtiList:BG10600" /db_xref="UniProtKB/Swiss-Prot:P39612" /translation="MDKETYVSEIKSGLKGLPEGEAMIEEIESHIEHHLFRSFQEGKS EEEAMQTLLQAFGTPTDIVSSFKKIQPVTFRAFLMFHLFCNSALFAVGIAITIMHVWL ESPFVQAVWKGISVSVWLILAAYMIYWVLIGYQGVKEFGKRGEKLVLHTILISMVPNV IFMLVFLFNVIPAALFQSLLTPWFVGTCAFATLLFPLFGRMGCYIGRRQLV*" /label="ywdD CDS" gene complement(3550968..3551603) /gene="ywdD" /locus_tag="BSU_38000" /old_locus_tag="BSU38000" /label="ywdD gene" CDS complement(3551596..3551934) /gene="ywzG" /locus_tag="BSU_38018" /old_locus_tag="BSU38018" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator, PadR family" /protein_id="YP_003097793.1" /db_xref="EnsemblGenomes-Gn:BSU38018" /db_xref="EnsemblGenomes-Tr:CAX52706" /db_xref="GOA:C0H3S6" /db_xref="InterPro:IPR005149" /db_xref="InterPro:IPR011991" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="UniProtKB/Swiss-Prot:C0H3S6" /translation="MLNRELVKGSTVILVLTLLNERPMYGYELVKEMGSRSGNELQMK EGTLYPSLHKLERQGYISSYWEKQEKGPDRKYYRITDEGKEVLAERTKEWSVFSAMMD RILKWSGQNG*" /label="ywzG CDS" gene complement(3551596..3551934) /gene="ywzG" /locus_tag="BSU_38018" /old_locus_tag="BSU38018" /label="ywzG gene" promotor_-10 complement(3551956..3551975) /Source="Nicolas_upshift_promotors" /id="U2984" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.468531468531469" /psig="0.998001998001998" /xcortree=2997 /SigmaFactorBS="gtatcacaatatagaagatctataggaatcATTTGACAatct caacgggcttTCGTAAAATGCTACATAAGAaaactaggtaggggttttgagatgttaa a" /listShort="ywzG, ywdD, ywdE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3551967) /Source="Nicolas_upshifts" /id="U2984" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.468531468531469" /psig="0.998001998001998" /xcortree=2997 /SigmaFactorBS="gtatcacaatatagaagatctataggaatcATTTGACAatct caacgggcttTCGTAAAATGCTACATAAGAaaactaggtaggggttttgagatgttaa a" /listShort="ywzG, ywdD, ywdE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3551990..3551997) /Source="Nicolas_upshift_promotors" /id="U2984" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.468531468531469" /psig="0.998001998001998" /xcortree=2997 /SigmaFactorBS="gtatcacaatatagaagatctataggaatcATTTGACAatct caacgggcttTCGTAAAATGCTACATAAGAaaactaggtaggggttttgagatgttaa a" /listShort="ywzG, ywdD, ywdE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3552018..3552021 /Source="Nicolas_upshift_promotors" /id="U2985" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.926073926073926" /psig=1 /xcortree=2350 /SigmaFactorBS="aagcccgttgagattgtcaaatgattcctatagatcttctat ATTGtgatacagagaaaaTCTAACTATAATGAAAGACAaaacatgatggaggttcaag a" /listShort="pdxK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3552036..3552055 /Source="Nicolas_upshift_promotors" /id="U2985" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.926073926073926" /psig=1 /xcortree=2350 /SigmaFactorBS="aagcccgttgagattgtcaaatgattcctatagatcttctat ATTGtgatacagagaaaaTCTAACTATAATGAAAGACAaaacatgatggaggttcaag a" /listShort="pdxK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3552036 /Source="Nicolas_upshifts" /id="U2985" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.926073926073926" /psig=1 /xcortree=2350 /SigmaFactorBS="aagcccgttgagattgtcaaatgattcctatagatcttctat ATTGtgatacagagaaaaTCTAACTATAATGAAAGACAaaacatgatggaggttcaag a" /listShort="pdxK" /GFF_Attribute="listLong" /label="upshifts" CDS 3552078..3552893 /gene="pdxK" /locus_tag="BSU_38020" /old_locus_tag="BSU38020" /EC_number="2.7.1.35" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10939241, 14973012, 17012797" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10939241, 14973012, 17012797; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="pyridoxine, pyridoxal, and pyridoxamine kinase" /protein_id="NP_391681.1" /db_xref="EnsemblGenomes-Gn:BSU38020" /db_xref="EnsemblGenomes-Tr:CAB15828" /db_xref="GOA:P39610" /db_xref="InterPro:IPR004399" /db_xref="InterPro:IPR013749" /db_xref="InterPro:IPR029056" /db_xref="PDB:2I5B" /db_xref="SubtiList:BG10598" /db_xref="UniProtKB/Swiss-Prot:P39610" /translation="MSMHKALTIAGSDSSGGAGIQADLKTFQEKNVYGMTALTVIVAM DPNNSWNHQVFPIDTDTIRAQLATITDGIGVDAMKTGMLPTVDIIELAAKTIKEKQLK NVVIDPVMVCKGANEVLYPEHAQALREQLAPLATVITPNLFEASQLSGMDELKTVDDM IEAAKKIHALGAQYVVITGGGKLKHEKAVDVLYDGETAEVLESEMIDTPYTHGAGCTF SAAVTAELAKGAEVKEAIYAAKEFITAAIKESFPLNQYVGPTKHSALRLNQQS*" /label="pdxK CDS" gene 3552078..3552893 /gene="pdxK" /locus_tag="BSU_38020" /old_locus_tag="BSU38020" /label="pdxK gene" downshifts 3552872 /Source="Nicolas_upshifts" /id="D1964" /incds=0 /nref=185 /ntot=251 /MaxReadThrough="2.56759" /MaxDrop="5.39956" /score="22.0760698" /energy="-18.1" /TU="NA" /idTUdmin="U2985" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(3552948) /Source="Nicolas_upshifts" /id="D1965" /incds=0 /nref=20 /ntot=111 /MaxReadThrough="0.56945" /MaxDrop="6.81686" /score="39.7901804" /energy="-16.8" /TU="NA" /idTUdmin="U2987" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3552983..3553231) /gene="ywdA" /locus_tag="BSU_38030" /old_locus_tag="BSU38030" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391682.1" /db_xref="EnsemblGenomes-Gn:BSU38030" /db_xref="EnsemblGenomes-Tr:CAB15829" /db_xref="SubtiList:BG10597" /db_xref="UniProtKB/Swiss-Prot:P39609" /translation="MNIHEQKITPECLEKAANQVEDKREEYKDVLLQLKKMLGGTTPH SETAEILTRAYEQMKEYALFVQSIETFLRKSANNLKIK*" /label="ywdA CDS" gene complement(3552983..3553231) /gene="ywdA" /locus_tag="BSU_38030" /old_locus_tag="BSU38030" /label="ywdA gene" downshifts complement(3553003) /Source="Nicolas_upshifts" /id="D1966" /incds=0 /nref=6 /ntot=123 /MaxReadThrough="6.75845" /MaxDrop="3.89221" /score="22.6408081" /energy="-10.8" /TU="U2987,U2988" /idTUdmin="U2986" /TUdmin=11 /isTUend="TRUE" /label="downshifts" upshifts complement(3553249) /Source="Nicolas_upshifts" /id="U2986" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.211788211788212" /psig="0.230769230769231" /xcortree=577 /SigmaFactorBS="tcttatgtgaaatctgagccatctgtgctattcttcaacgat aaCCTACTAtttttttctgtaaaaggagttgttttcttgaatatacatgaacagaaga t" /listShort="ywdA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3553251..3553324) /Source="Nicolas_S_feature" /locus_tag="new_3902136_3902209_c" /HighExp="G150, Mt0, Diami, Lbexp, dia0, dia5, T0.30H, Oxctl, Etha, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.536, 0.743, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1464" misc_feature complement(3553259..3553265) /Source="Nicolas_upshift_promotors" /id="U2986" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.211788211788212" /psig="0.230769230769231" /xcortree=577 /SigmaFactorBS="tcttatgtgaaatctgagccatctgtgctattcttcaacgat aaCCTACTAtttttttctgtaaaaggagttgttttcttgaatatacatgaacagaaga t" /listShort="ywdA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(3553325..3554764) /gene="sacA" /locus_tag="BSU_38040" /old_locus_tag="BSU38040" /EC_number="3.2.1.26" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 3100393; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sucrose-6-phosphate hydrolase" /protein_id="NP_391683.2" /db_xref="EnsemblGenomes-Gn:BSU38040" /db_xref="EnsemblGenomes-Tr:CAB15830" /db_xref="GOA:P07819" /db_xref="InterPro:IPR001362" /db_xref="InterPro:IPR006232" /db_xref="InterPro:IPR013148" /db_xref="InterPro:IPR013189" /db_xref="InterPro:IPR013320" /db_xref="InterPro:IPR018053" /db_xref="InterPro:IPR023296" /db_xref="SubtiList:BG10596" /db_xref="UniProtKB/Swiss-Prot:P07819" /translation="MTAHDQELRRRAYEEVEKKEPIANSDPHRQHFHIMPPVGLLNDP NGVIYWKGSYHVFFQWQPFQTGHGAKFWGHYTTQDVVNWKREEIALAPSDWFDKNGCY SGSAVTKDDRLYLFYTGNVRDQDGNRETYQCLAVSDDGLSFEKKGVVARLPEGYTAHF RDPKVWEHEGTWYMVIGAQTENLKGQAVLFASDNLTEWRFLGPITGAGFNGLDDFGYM WECPDLFSLQGSDVLIVSPQGLEADGFRYQNVYQSGYFVGRLDYNKPELKHGEFTELD QGFDFYAPQTLEDDQGRRILFAWMAVPDQDEGSHPTIDCHWIHCMTLPRQLTLSGQKL IQQPLPELKAMRRNEKKIHINMHGSSGALPVEKPERTEILLEDIHTESGFSISIRGTA TFSFHKDEGIVTLERKSFDGKRTEARHCRIKDLHTVHMFLDASSVEIFINNGEEVLSA RYFPFPGNHEVTASATGKSEMNVGIWTLM*" /label="sacA CDS" gene complement(3553325..3554764) /gene="sacA" /locus_tag="BSU_38040" /old_locus_tag="BSU38040" /label="sacA gene" CDS complement(3554761..3556146) /gene="sacP" /locus_tag="BSU_38050" /old_locus_tag="BSU38050" /EC_number="2.7.1.211" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:1577686, 3122206, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1577686, 3122206, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) sucrose-specificenzyme IIBC component" /protein_id="NP_391684.3" /db_xref="EnsemblGenomes-Gn:BSU38050" /db_xref="EnsemblGenomes-Tr:CAB15831" /db_xref="GOA:P05306" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR004719" /db_xref="InterPro:IPR010973" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="SubtiList:BG10595" /db_xref="UniProtKB/Swiss-Prot:P05306" /translation="MDYKETAKRLIELLGGKENIISAAHCATRLRLVMKDESKIDQAQ VEELDGVKGAFSSSGQYQIIFGTGLVNKVFDAFSKEADIEREEHVNHQDAAKEKLNPA ARFAKTLSNIFVPIIPAIVASGLLMGLLGMINAFHWMSKDSALLQLLDMFSSAAFIFL PILIGVSASKEFGSNPYLGAVIGGIMIHPNLLNPWGLAEATPDYMHLFGFDIALLGYQ GTVIPVLLAVYVMSKVEKWTRKVVPHAVDLLVTPFVTVIVTGFVAFIAIGPLGRALGS GITVALTYVYDHAGFVAGLIFGGTYSLIVLTGVHHSFHAIEAGLIADIGKNYLLPIWS MANVAQGGAGLAVFFMAKKAKTKEIALPAAFSAFLGITEPVIFGVNLRYRKPFIAAMI GGALGGAYVVFTHVAANAYGLTGIPMIAIAAPFGFSNLIHYLIGMAIAAVSAFIAAFV MKINEDEERKK*" /label="sacP CDS" gene complement(3554761..3556146) /gene="sacP" /locus_tag="BSU_38050" /old_locus_tag="BSU38050" /label="sacP gene" misc_feature complement(3556165..3556174) /Source="Nicolas_upshift_promotors" /id="U2987" /multdbtbs="-" /comp="M21" /sig="SigA" /pcomp="0.258741258741259" /psig="0.536463536463537" /xcortree=1560 /SigmaFactorBS="ctaaaatttgcgtaaatgaaaaaggatcgctgtgtcctttat tcgttggcgaattttaggtctttTTTGTTTAAAtaaaagggggagaaatagatggatt a" /listShort="sacP, sacA, S1464, ywdA" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3556179) /Source="Nicolas_upshifts" /id="U2987" /multdbtbs="-" /comp="M21" /sig="SigA" /pcomp="0.258741258741259" /psig="0.536463536463537" /xcortree=1560 /SigmaFactorBS="ctaaaatttgcgtaaatgaaaaaggatcgctgtgtcctttat tcgttggcgaattttaggtctttTTTGTTTAAAtaaaagggggagaaatagatggatt a" /listShort="sacP, sacA, S1464, ywdA" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3556181..3556245) /Source="Nicolas_S_feature" /locus_tag="new_3905066_3905130_c" /HighExp="Diami, G150, dia5, Mt0, M9-stat, Lbtran, Gly, dia0, Oxctl, Lbexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.743, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1465" promotor_-10 complement(3556224..3556241) /Source="Nicolas_upshift_promotors" /id="U2988" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.538461538461538" /psig="0.743256743256743" /xcortree=1561 /SigmaFactorBS="gatttatgatgaaagcgtattcttaatctgaataagcgggaT TGTGACTggtaaagcaggcaagACCTAAAATTTGCGTAAAtgaaaaaggatcgctgtg t" /listShort="S1465, sacP, sacA, S1464, ywdA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3556245) /Source="Nicolas_upshifts" /id="U2988" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.538461538461538" /psig="0.743256743256743" /xcortree=1561 /SigmaFactorBS="gatttatgatgaaagcgtattcttaatctgaataagcgggaT TGTGACTggtaaagcaggcaagACCTAAAATTTGCGTAAAtgaaaaaggatcgctgtg t" /listShort="S1465, sacP, sacA, S1464, ywdA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3556257..3556264) /Source="Nicolas_upshift_promotors" /id="U2988" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.538461538461538" /psig="0.743256743256743" /xcortree=1561 /SigmaFactorBS="gatttatgatgaaagcgtattcttaatctgaataagcgggaT TGTGACTggtaaagcaggcaagACCTAAAATTTGCGTAAAtgaaaaaggatcgctgtg t" /listShort="S1465, sacP, sacA, S1464, ywdA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3556287..3556306) /Source="Nicolas_upshift_promotors" /id="U2989" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1544 /SigmaFactorBS="ttgtctacatgttatatcaaactatttaactaaaaaaaTAGT TGACgaaaacgctatcaTGATTTATGATGAAAGCGTAttcttaatctgaataagcggg a" /listShort="S1465, sacP, sacA, S1464, ywdA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3556305) /Source="Nicolas_upshifts" /id="U2989" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1544 /SigmaFactorBS="ttgtctacatgttatatcaaactatttaactaaaaaaaTAGT TGACgaaaacgctatcaTGATTTATGATGAAAGCGTAttcttaatctgaataagcggg a" /listShort="S1465, sacP, sacA, S1464, ywdA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3556320..3556327) /Source="Nicolas_upshift_promotors" /id="U2989" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.98001998001998" /psig=1 /xcortree=1544 /SigmaFactorBS="ttgtctacatgttatatcaaactatttaactaaaaaaaTAGT TGACgaaaacgctatcaTGATTTATGATGAAAGCGTAttcttaatctgaataagcggg a" /listShort="S1465, sacP, sacA, S1464, ywdA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3556386..3556389 /Source="Nicolas_upshift_promotors" /id="U2990" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.676323676323676" /psig="0.997002997002997" /xcortree=1600 /SigmaFactorBS="gttaaatagtttgatataacatgtagacaaaaattcgtaaaa attaattgTGAAatacttcacaatatCGTGCTATACTATGCTCAATcatgaaagaaag c" /listShort="ywcJ, S1466" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3556396 /Source="Nicolas_upshifts" /id="U2990" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.676323676323676" /psig="0.997002997002997" /xcortree=1600 /SigmaFactorBS="gttaaatagtttgatataacatgtagacaaaaattcgtaaaa attaattgTGAAatacttcacaatatCGTGCTATACTATGCTCAATcatgaaagaaag c" /listShort="ywcJ, S1466" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3556404..3556423 /Source="Nicolas_upshift_promotors" /id="U2990" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.676323676323676" /psig="0.997002997002997" /xcortree=1600 /SigmaFactorBS="gttaaatagtttgatataacatgtagacaaaaattcgtaaaa attaattgTGAAatacttcacaatatCGTGCTATACTATGCTCAATcatgaaagaaag c" /listShort="ywcJ, S1466" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3556448..3557218 /gene="nirC" /locus_tag="BSU_38060" /old_locus_tag="BSU38060" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15849754, 16207915, 16428414, 16850406, 18691156; Product type t : transporter" /codon_start=1 /transl_table=11 /product="nitrite transporter" /protein_id="NP_391685.1" /db_xref="EnsemblGenomes-Gn:BSU38060" /db_xref="EnsemblGenomes-Tr:CAB15832" /db_xref="GOA:P39608" /db_xref="InterPro:IPR000292" /db_xref="InterPro:IPR023271" /db_xref="InterPro:IPR024002" /db_xref="SubtiList:BG10594" /db_xref="UniProtKB/Swiss-Prot:P39608" /translation="METQALQKVEQYALKKQNIFASSKIRYVLRSILASIFIGFGITA ASKTGSYFFMADSPFAFPAAAVTFGAAILMIAYGGGDLFTGNTFYFTYTALRKKISWR DTLYLWMSSYAGNLIGAILFAILISATGLFEEPSVHSFLIHLAEHKMEPPASELFFRG MLCNWLVCLAFFIPMSLKGEGAKLFTMMLFVFCFFISGFEHSIANMCTFAISLLIEHP DTVTLMGAVRNLIPVTLGNLTAGIVMMGWMYYTLNPDQ*" /label="nirC CDS" gene 3556448..3557218 /gene="nirC" /locus_tag="BSU_38060" /old_locus_tag="BSU38060" /label="nirC gene" S_feature 3557219..3558286 /Source="Nicolas_S_feature" /locus_tag="new_3906104_3907171" /HighExp="S0, ferm, M0t45, Lbexp, Mal, dia0, M/G, UNK1, M40t45, BI" /AntisenseName="sacT" /AntisenseCor="-0.34218080984654098" /AntisenseRegPval="-8.1" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1466" CDS complement(3557257..3558087) /gene="sacT" /locus_tag="BSU_38070" /old_locus_tag="BSU38070" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:1577686, 2163394, 8535520, 8702561, 19202299, 21278164" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1577686, 2163394, 8535520, 8702561, 19202299, 21278164; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional antiterminator of sacAP expression" /protein_id="NP_391686.1" /db_xref="EnsemblGenomes-Gn:BSU38070" /db_xref="EnsemblGenomes-Tr:CAB15833" /db_xref="GOA:P26212" /db_xref="InterPro:IPR001550" /db_xref="InterPro:IPR004341" /db_xref="InterPro:IPR011608" /db_xref="InterPro:IPR036634" /db_xref="InterPro:IPR036650" /db_xref="SubtiList:BG10593" /db_xref="UniProtKB/Swiss-Prot:P26212" /translation="MKIYKVLNNNAALIKEDDQEKIVMGPGIAFQKKKNDLIPMNKVE KIFVVRDENEKFKQILQTLPEEHIEIAEDIISYAEGELAAPLSDHIHIALSDHLSFAI ERIQNGLLVQNKLLHEIKALYKKEYEIGLWAIGHVKETLGVSLPEDEAGYIALHIHTA KMDAESMYSALKHTTMIKEMIEKIKQYFNRKVDENSISYQRLVTHLRYAVSRLESNEA LHRMDEEMLYFIQKKYSFAYQCALELAEFLKNEYQLHLPESEAGYITLHVQRLQDLSE *" /label="sacT CDS" gene complement(3557257..3558087) /gene="sacT" /locus_tag="BSU_38070" /old_locus_tag="BSU38070" /label="sacT gene" downshifts complement(3557258) /Source="Nicolas_upshifts" /id="D1967" /incds=0 /nref=49 /ntot=139 /MaxReadThrough="3.34691" /MaxDrop="4.9787" /score="11.2756812" /energy="-8.1" /TU="U2992" /idTUdmin="U2991" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3558113..3558132) /Source="Nicolas_upshift_promotors" /id="U2991" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.72027972027972" /psig="0.943056943056943" /xcortree=452 /SigmaFactorBS="caaagcaggagagagcgggcccgcaTCTTTACAtggcggtca aaaggAGGTAAAATCCCAGTCAAAAgcaaattggcgggagagataacctcttgaaaat c" /listShort="sacT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3558119) /Source="Nicolas_upshifts" /id="U2991" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.72027972027972" /psig="0.943056943056943" /xcortree=452 /SigmaFactorBS="caaagcaggagagagcgggcccgcaTCTTTACAtggcggtca aaaggAGGTAAAATCCCAGTCAAAAgcaaattggcgggagagataacctcttgaaaat c" /listShort="sacT" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3558127..3558429) /gene="ywcI" /locus_tag="BSU_38080" /old_locus_tag="BSU38080" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 22720735" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391687.2" /db_xref="EnsemblGenomes-Gn:BSU38080" /db_xref="EnsemblGenomes-Tr:CAB15834" /db_xref="SubtiList:BG10592" /db_xref="UniProtKB/Swiss-Prot:P39607" /translation="MKRLLVSLRVWMVFLMNWVTPDRKTAAAAVYSAQRTYQRKAAVQ AAGLVSFYEWRMAVNEEEKQKAKAAALYKRRCLQAFKESPKQERAGPHLYMAVKRR*" /label="ywcI CDS" gene complement(3558127..3558429) /gene="ywcI" /locus_tag="BSU_38080" /old_locus_tag="BSU38080" /label="ywcI gene" promotor_-35 complement(3558147..3558154) /Source="Nicolas_upshift_promotors" /id="U2991" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.72027972027972" /psig="0.943056943056943" /xcortree=452 /SigmaFactorBS="caaagcaggagagagcgggcccgcaTCTTTACAtggcggtca aaaggAGGTAAAATCCCAGTCAAAAgcaaattggcgggagagataacctcttgaaaat c" /listShort="sacT" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3558430..3558568) /Source="Nicolas_S_feature" /locus_tag="new_3907315_3907453_c" /HighExp="T5.0H, M9-stat, S2, S4, T4.0H, S3, T3.30H, LoTm, B36, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.823" /TUlongSig="NA" /TUlongPSig="NA" /label="S1467" misc_feature complement(3558553..3558572) /Source="Nicolas_upshift_promotors" /id="U2992" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.388611388611389" /psig="0.823176823176823" /xcortree=968 /SigmaFactorBS="cttctaaaaactagttggttttttcactcatattgtgacaaa gaattctctttccaCGGTCTATCATAGAGTCATGagttttgctagagccgctagtttg c" /listShort="S1467, ywcI, sacT" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3558568) /Source="Nicolas_upshifts" /id="U2992" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.388611388611389" /psig="0.823176823176823" /xcortree=968 /SigmaFactorBS="cttctaaaaactagttggttttttcactcatattgtgacaaa gaattctctttccaCGGTCTATCATAGAGTCATGagttttgctagagccgctagtttg c" /listShort="S1467, ywcI, sacT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3558883..3558891 /Source="Nicolas_upshift_promotors" /id="U2993" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=466 /SigmaFactorBS="gttatacacaaacaaaatccaataaatggtccaaatgacaCA AGGATTTttttgaatttTCAAGAAATATATACTAGAtctttcacattttttctaaata c" /listShort="vpr" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3558902..3558920 /Source="Nicolas_upshift_promotors" /id="U2993" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=466 /SigmaFactorBS="gttatacacaaacaaaatccaataaatggtccaaatgacaCA AGGATTTttttgaatttTCAAGAAATATATACTAGAtctttcacattttttctaaata c" /listShort="vpr" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3558903 /Source="Nicolas_upshifts" /id="U2993" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.983016983016983" /psig="0.983016983016983" /xcortree=466 /SigmaFactorBS="gttatacacaaacaaaatccaataaatggtccaaatgacaCA AGGATTTttttgaatttTCAAGAAATATATACTAGAtctttcacattttttctaaata c" /listShort="vpr" /GFF_Attribute="listLong" /label="upshifts" CDS 3558959..3561379 /gene="vpr" /locus_tag="BSU_38090" /old_locus_tag="BSU38090" /EC_number="3.4.21.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15205417, 15596354, 16946274, 17666034, 18689487, 25666135" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15205417, 15596354, 16946274, 17666034, 18689487, 25666135; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="extracellular serine protease" /protein_id="NP_391688.1" /db_xref="EnsemblGenomes-Gn:BSU38090" /db_xref="EnsemblGenomes-Tr:CAB15835" /db_xref="GOA:P29141" /db_xref="InterPro:IPR000209" /db_xref="InterPro:IPR003137" /db_xref="InterPro:IPR010259" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR015500" /db_xref="InterPro:IPR022398" /db_xref="InterPro:IPR023827" /db_xref="InterPro:IPR023828" /db_xref="InterPro:IPR025965" /db_xref="InterPro:IPR034213" /db_xref="InterPro:IPR036852" /db_xref="InterPro:IPR037045" /db_xref="SubtiList:BG10591" /db_xref="UniProtKB/Swiss-Prot:P29141" /translation="MKKGIIRFLLVSFVLFFALSTGITGVQAAPASSKTSADLEKAEV FGDIDMTTSKKTTVIVELKEKSLAEAKEAGESQSKSKLKTARTKAKNKAIKAVKNGKV NREYEQVFSGFSMKLPANEIPKLLAVKDVKAVYPNVTYKTDNMKDKDVTISEDAVSPQ MDDSAPYIGANDAWDLGYTGKGIKVAIIDTGVEYNHPDLKKNFGQYKGYDFVDNDYDP KETPTGDPRGEATDHGTHVAGTVAANGTIKGVAPDATLLAYRVLGPGGSGTTENVIAG VERAVQDGADVMNLSLGNSLNNPDWATSTALDWAMSEGVVAVTSNGNSGPNGWTVGSP GTSREAISVGATQLPLNEYAVTFGSYSSAKVMGYNKEDDVKALNNKEVELVEAGIGEA KDFEGKDLTGKVAVVKRGSIAFVDKADNAKKAGAIGMVVYNNLSGEIEANVPGMSVPT IKLSLEDGEKLVSALKAGETKTTFKLTVSKALGEQVADFSSRGPVMDTWMIKPDISAP GVNIVSTIPTHDPDHPYGYGSKQGTSMASPHIAGAVAVIKQAKPKWSVEQIKAAIMNT AVTLKDSDGEVYPHNAQGAGSARIMNAIKADSLVSPGSYSYGTFLKENGNETKNETFT IENQSSIRKSYTLEYSFNGSGISTSGTSRVVIPAHQTGKATAKVKVNTKKTKAGTYEG TVIVREGGKTVAKVPTLLIVKEPDYPRVTSVSVSEGSVQGTYQIETYLPAGAEELAFL VYDSNLDFAGQAGIYKNQDKGYQYFDWDGTINGGTKLPAGEYYLLAYAANKGKSSQVL TEEPFTVE*" /label="vpr CDS" gene 3558959..3561379 /gene="vpr" /locus_tag="BSU_38090" /old_locus_tag="BSU38090" /label="vpr gene" upshifts 3559117 /Source="Nicolas_upshifts" /id="U2994" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.677322677322677" /psig="0.986013986013986" /xcortree=625 /SigmaFactorBS="aaaaacgtcggctgatctggaaaaagccgaggtattcggtga tatcgatatgacgacaagcaaaaaaacAACCGTTATAGTGGAATTAAaagaaaaatcc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 3559126..3559145 /Source="Nicolas_upshift_promotors" /id="U2994" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.677322677322677" /psig="0.986013986013986" /xcortree=625 /SigmaFactorBS="aaaaacgtcggctgatctggaaaaagccgaggtattcggtga tatcgatatgacgacaagcaaaaaaacAACCGTTATAGTGGAATTAAaagaaaaatcc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" downshifts 3561367 /Source="Nicolas_upshifts" /id="D1968" /incds=0 /nref=7 /ntot=104 /MaxReadThrough="0.60305" /MaxDrop="5.33856" /score="26.8487936" /energy="-16.5" /TU="NA" /idTUdmin="U2993" /TUdmin=6 /isTUend="TRUE" /label="downshifts" CDS complement(3561417..3562418) /gene="ywcH" /locus_tag="BSU_38100" /old_locus_tag="BSU38100" /EC_number="1.14.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10913069, 15774866; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative monooxygenase" /protein_id="NP_391689.1" /db_xref="EnsemblGenomes-Gn:BSU38100" /db_xref="EnsemblGenomes-Tr:CAB15836" /db_xref="GOA:P39606" /db_xref="InterPro:IPR011251" /db_xref="InterPro:IPR019949" /db_xref="InterPro:IPR036661" /db_xref="SubtiList:BG10590" /db_xref="UniProtKB/Swiss-Prot:P39606" /translation="MVSLSILDQSPVSEGSNAETALQQTVALAQAAEDLGYKRFWVSE HHFSKRLAGSSPEVLISHIAAKTKRIRVGSGGVMLPHYSAYKVAENFRVLEGLTPGRI DLGLGRAPGGMPIASWALNDGGKRNADQYPQQIKELTMYLHDLADDKHRFPNLTAAPH ISTAPDVWLLGSSGESALLAAESGAGYMFAHFINGEGGEGTVRQYKRRFKPSVLGDTP RAAVAVFVLCADTEEKAEELGAVLDFTLLAGEQGIPLEGVPSYEAVRKNTYSPYEQRR IADNRNRMIVGTKEQVKERLLALSNAYETEEIMVVTITHHFEDKLRSYRLLQEAFAD* " /label="ywcH CDS" gene complement(3561417..3562418) /gene="ywcH" /locus_tag="BSU_38100" /old_locus_tag="BSU38100" /label="ywcH gene" S_feature complement(3562419..3562580) /Source="Nicolas_S_feature" /locus_tag="new_3911304_3911465_c" /HighExp="Etha, Diami, dia15, LPhT, dia5, H2O2, B60, LBGstat, M9-stat, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigWXY" /TUlongPSig=1 /label="S1468" CDS complement(3562592..3563341) /gene="nfrAA" /locus_tag="BSU_38110" /old_locus_tag="BSU38110" /EC_number="1.5.1.38" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9535080, 9836433, 10913069, 15774866, 20727352, 20862523, 24847778, 25288929" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9535080, 9836433, 10913069, 15774866, 20727352, 20862523, 24847778, 25288929; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="FMN-containing NADPH-linked nitro/flavin reductase" /protein_id="NP_391690.1" /db_xref="EnsemblGenomes-Gn:BSU38110" /db_xref="EnsemblGenomes-Tr:CAB15837" /db_xref="GOA:P39605" /db_xref="InterPro:IPR000415" /db_xref="InterPro:IPR016446" /db_xref="InterPro:IPR029479" /db_xref="PDB:3N2S" /db_xref="SubtiList:BG10589" /db_xref="UniProtKB/Swiss-Prot:P39605" /translation="MNNTIETILNHRSIRSFTDQLLTAEEIDTLVKSAQAASTSSYVQ AYSIIGVSDPEKKRELSVLAGNQPYVEKNGHFFVFCADLYRHQQLAEEKGEHISELLE NTEMFMVSLIDAALAAQNMSIAAESMGLGICYIGGIRNELDKVTEVLQTPDHVLPLFG LAVGHPANLSGKKPRLPKQAVYHENTYNVNTDDFRHTMNTYDKTISDYYRERTNGKRE ETWSDQILNFMKQKPRTYLNDYVKEKGFNKN*" /label="nfrAA CDS" gene complement(3562592..3563341) /gene="nfrAA" /locus_tag="BSU_38110" /old_locus_tag="BSU38110" /label="nfrAA gene" downshifts complement(3562625) /Source="Nicolas_upshifts" /id="D1969" /incds=0 /nref=11 /ntot=191 /MaxReadThrough="5.92216" /MaxDrop="3.39651" /score="17.7447455" /energy="-9.9" /TU="U2995" /idTUdmin="U2996" /TUdmin=770 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3563359..3563378) /Source="Nicolas_upshift_promotors" /id="U2995" /multdbtbs="SigA,SigD" /comp="M7" /sig="SigA" /pcomp="0.792207792207792" /psig=1 /xcortree=2037 /SigmaFactorBS="gcctttacagaggctgtctttttttgtgcagagcatttcaCT TTtgagatcactttttTTCGGATATGATAAAAAGTGataaggaggtttttgtgatgaa t" /listShort="nfrA, S1468, ywcH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3563376) /Source="Nicolas_upshifts" /id="U2995" /multdbtbs="SigA,SigD" /comp="M7" /sig="SigA" /pcomp="0.792207792207792" /psig=1 /xcortree=2037 /SigmaFactorBS="gcctttacagaggctgtctttttttgtgcagagcatttcaCT TTtgagatcactttttTTCGGATATGATAAAAAGTGataaggaggtttttgtgatgaa t" /listShort="nfrA, S1468, ywcH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3563393..3563396) /Source="Nicolas_upshift_promotors" /id="U2995" /multdbtbs="SigA,SigD" /comp="M7" /sig="SigA" /pcomp="0.792207792207792" /psig=1 /xcortree=2037 /SigmaFactorBS="gcctttacagaggctgtctttttttgtgcagagcatttcaCT TTtgagatcactttttTTCGGATATGATAAAAAGTGataaggaggtttttgtgatgaa t" /listShort="nfrA, S1468, ywcH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3563447..3564628) /gene="rodA" /locus_tag="BSU_38120" /old_locus_tag="BSU38120" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:9622350, 15612918, 15849754, 16850406, 28085152" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9622350, 15612918, 15849754, 16850406, 28085152; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glycosyltransferase involved in extension of thelateral walls of the cell" /protein_id="NP_391691.1" /db_xref="EnsemblGenomes-Gn:BSU38120" /db_xref="EnsemblGenomes-Tr:CAB15838" /db_xref="GOA:P39604" /db_xref="InterPro:IPR001182" /db_xref="InterPro:IPR018365" /db_xref="SubtiList:BG10588" /db_xref="UniProtKB/Swiss-Prot:P39604" /translation="MSRYKKQQSPFYQGDLIFIFGVFFIISVVSIYAAGQFGQYGNTD WIQQIVFYLLGAVAITVLLYFDLEQLEKLSLYIFIIGILSLIILKISPESIAPVIKGA KSWFRIGRITIQPSEFMKVGLIMMLASVIGKANPKGVRTLRDDIHLLLKIAGVAVIPV GLILMQDAGTAGICMFIVLVMVFMSGINWKLIAIIAGSGILLISLILLVMINFPDVAK SVGIQDYQIKRVTSWVSASNETQEDSNDSWQVDQAIMAIGSGGILGNGISNLKVYVPE STTDFIFSIIGESFGFIGCAIVVIMFFFLIYRLVVLIDKIHPFNRFASFFCVGYTALI VIHTFQNIGMNIGIMPVTGIPLLFVSYGGSSTLSTLIGFGIVYNASVQLTKYRSYLFN S*" /label="rodA CDS" gene complement(3563447..3564628) /gene="rodA" /locus_tag="BSU_38120" /old_locus_tag="BSU38120" /label="rodA gene" downshifts complement(3563461) /Source="Nicolas_upshifts" /id="D1970" /incds=0 /nref=20 /ntot=124 /MaxReadThrough="3.38052" /MaxDrop="5.67563" /score="31.4805549" /energy="-13.3" /TU="U2996" /idTUdmin="U2996" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" S_feature complement(3564629..3564760) /Source="Nicolas_S_feature" /locus_tag="new_3913514_3913645_c" /HighExp="Heat, T0.30H, H2O2, T1.0H, Salt, Paraq, T1.30H, LBGstat, Oxctl, G180" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1469" promotor_-10 complement(3564754..3564769) /Source="Nicolas_upshift_promotors" /id="U2996" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1657 /SigmaFactorBS="tttttttcatttgaaaagttttgtgtcaatCGAAACATTTcg gtttatgatACGTCATATTTCGTGTagctgaaaaagcgccgcaaatgctgaaaaaaca t" /listShort="S1469, rodA" /listLong="nfrA, S1468, ywcH" /label="promotor_-10" upshifts complement(3564760) /Source="Nicolas_upshifts" /id="U2996" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1657 /SigmaFactorBS="tttttttcatttgaaaagttttgtgtcaatCGAAACATTTcg gtttatgatACGTCATATTTCGTGTagctgaaaaagcgccgcaaatgctgaaaaaaca t" /listShort="S1469, rodA" /listLong="nfrA, S1468, ywcH" /label="upshifts" promotor_-35 complement(3564781..3564790) /Source="Nicolas_upshift_promotors" /id="U2996" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1657 /SigmaFactorBS="tttttttcatttgaaaagttttgtgtcaatCGAAACATTTcg gtttatgatACGTCATATTTCGTGTagctgaaaaagcgccgcaaatgctgaaaaaaca t" /listShort="S1469, rodA" /listLong="nfrA, S1468, ywcH" /label="promotor_-35" promotor_-35 3564995..3565002 /Source="Nicolas_upshift_promotors" /id="U2997" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=437 /SigmaFactorBS="aaaaaataagacgatagatccagtccatttctgcaaaaacac GTATCAATttctggaaaaCATGGTATAATAATTGTAACagaatgttcaaaaaacaatc a" /listShort="S1470, ywcE" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3565013..3565123 /Source="Nicolas_S_feature" /locus_tag="new_3913898_3914008" /HighExp="M9-stat, T0.30H, T1.30H, T1.0H, T4.0H, T2.30H, T3.30H, T3.0H, T5.0H, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1470" promotor_-10 3565013..3565032 /Source="Nicolas_upshift_promotors" /id="U2997" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=437 /SigmaFactorBS="aaaaaataagacgatagatccagtccatttctgcaaaaacac GTATCAATttctggaaaaCATGGTATAATAATTGTAACagaatgttcaaaaaacaatc a" /listShort="S1470, ywcE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3565013 /Source="Nicolas_upshifts" /id="U2997" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=437 /SigmaFactorBS="aaaaaataagacgatagatccagtccatttctgcaaaaacac GTATCAATttctggaaaaCATGGTATAATAATTGTAACagaatgttcaaaaaacaatc a" /listShort="S1470, ywcE" /GFF_Attribute="listLong" /label="upshifts" CDS 3565124..3565387 /gene="ywcE" /locus_tag="BSU_38130" /old_locus_tag="BSU38130" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16159778" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16159778; Product type f: factor" /codon_start=1 /transl_table=11 /product="holin-like protein required for proper spore morphogenesis and germination" /protein_id="NP_391692.1" /db_xref="EnsemblGenomes-Gn:BSU38130" /db_xref="EnsemblGenomes-Tr:CAB15839" /db_xref="GOA:P39603" /db_xref="InterPro:IPR020185" /db_xref="SubtiList:BG10587" /db_xref="UniProtKB/Swiss-Prot:P39603" /translation="MMDMFFAYLLVASATPLFIWLDNKKVALSAIPPIILMWVFFFFY ATESLSPLGHTLMIILFAVNVIVAHIAAFIIYGLPYLRRKRSS*" /label="ywcE CDS" gene 3565124..3565387 /gene="ywcE" /locus_tag="BSU_38130" /old_locus_tag="BSU38130" /label="ywcE gene" downshifts 3565277 /Source="Nicolas_upshifts" /id="D1971" /incds=1 /nref=1 /ntot=99 /MaxReadThrough="6.85004" /MaxDrop="2.5697" /score="27.9247684" /energy="-11.4" /TU="U2997" /idTUdmin="U2997" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" downshifts 3565393 /Source="Nicolas_upshifts" /id="D1972" /incds=0 /nref=7 /ntot=90 /MaxReadThrough="2.04756" /MaxDrop="6.52141" /score="27.9247684" /energy="-11.4" /TU="NA" /idTUdmin="U2997" /TUdmin=6 /isTUend="TRUE" /label="downshifts" CDS complement(3565430..3565804) /gene="qoxD" /locus_tag="BSU_38140" /old_locus_tag="BSU38140" /EC_number="1.10.3.12" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1316894, 7495838, 7575098, 10551842, 15849754, 16850406, 26196462" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1316894, 7495838, 7575098, 10551842, 15849754, 16850406, 26196462; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome aa3-600 quinol oxidase (subunit IV)" /protein_id="NP_391693.1" /db_xref="EnsemblGenomes-Gn:BSU38140" /db_xref="EnsemblGenomes-Tr:CAB15840" /db_xref="GOA:P34959" /db_xref="InterPro:IPR005171" /db_xref="InterPro:IPR014250" /db_xref="SubtiList:BG10586" /db_xref="UniProtKB/Swiss-Prot:P34959" /translation="MANKSAEHSHFPWKHIVGFILSIVLTLLALWVAVYTDLSSSAKL WIIFGFAFIQAALQLLMFMHMTESENGTIQVGNTLFGFFGAIVIVLGSIWIFAAHYHH GDHMDGNPPGGAEHSEHSGHNE*" /label="qoxD CDS" gene complement(3565430..3565804) /gene="qoxD" /locus_tag="BSU_38140" /old_locus_tag="BSU38140" /label="qoxD gene" downshifts complement(3565441) /Source="Nicolas_upshifts" /id="D1973" /incds=0 /nref=222 /ntot=267 /MaxReadThrough="2.42368" /MaxDrop="9.0593" /score="21.3154492" /energy="-11.4" /TU="NA" /idTUdmin="U3000" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3565806..3566420) /gene="qoxC" /locus_tag="BSU_38150" /old_locus_tag="BSU38150" /EC_number="1.10.3.12" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1316894, 7495838, 7575098, 10551842, 15849754, 16850406, 26196462" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1316894, 7495838, 7575098, 10551842, 15849754, 16850406, 26196462; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome aa3-600 quinol oxidase (subunit III)" /protein_id="NP_391694.1" /db_xref="EnsemblGenomes-Gn:BSU38150" /db_xref="EnsemblGenomes-Tr:CAB15841" /db_xref="GOA:P34958" /db_xref="InterPro:IPR000298" /db_xref="InterPro:IPR013833" /db_xref="InterPro:IPR014246" /db_xref="InterPro:IPR024791" /db_xref="InterPro:IPR033946" /db_xref="InterPro:IPR035973" /db_xref="SubtiList:BG10585" /db_xref="UniProtKB/Swiss-Prot:P34958" /translation="MEHAEHGNSNAPMEYQSETGRLNILGFWIFLGAEIVLFSTLFAT FFVLKNRTAGGVLPDELFEVNLVMIMTFLLLISSFTCGIAVHEMRRGSLKGVVIWTII TLLLGAGFVGCEINEFVHYVHEGAALSTSAFWSGFFVLLGTHGTHVTIGIFWITGILI QLKKRGLTPQTSSKIFISSLYWHFLDVVWIFIFTGVYLMGLGGL*" /label="qoxC CDS" gene complement(3565806..3566420) /gene="qoxC" /locus_tag="BSU_38150" /old_locus_tag="BSU38150" /label="qoxC gene" CDS complement(3566434..3568383) /gene="qoxB" /locus_tag="BSU_38160" /old_locus_tag="BSU38160" /EC_number="1.10.3.12" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1316894, 7495838, 7575098, 10551842, 15849754, 16850406, 22720735, 26196462" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1316894, 7495838, 7575098, 10551842, 15849754, 16850406, 22720735, 26196462; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome aa3-600 quinol oxidase (subunit I)" /protein_id="NP_391695.1" /db_xref="EnsemblGenomes-Gn:BSU38160" /db_xref="EnsemblGenomes-Tr:CAB15842" /db_xref="GOA:P34956" /db_xref="InterPro:IPR000883" /db_xref="InterPro:IPR014233" /db_xref="InterPro:IPR023615" /db_xref="InterPro:IPR023616" /db_xref="InterPro:IPR036927" /db_xref="SubtiList:BG10584" /db_xref="UniProtKB/Swiss-Prot:P34956" /translation="MKFKWDEFFVTGDPLILGAQVSIALSTIAIIFVLTYFKKWKWLW SEWITTVDHKKLGIMYIISAVIMLFRGGVDGLMMRAQLALPNNSFLDSNHYNEIFTTH GTIMIIFMAMPFLIGLINVVVPLQIGARDVAFPYLNNLSFWTFFVGAMLFNISFVIGG SPNAGWTSYMPLASNDMSPGPGENYYLLGLQIAGIGTLMTGINFMVTILKMRTKGMTL MRMPMFTWTTLITMVIIVFAFPVLTVALALLSFDRLFGAHFFTLEAGGMPMLWANLFW IWGHPEVYIVILPAFGIFSEIISSFARKQLFGYKAMVGSIIAISVLSFLVWTHHFFTM GNSASVNSFFSITTMAISIPTGVKIFNWLFTMYKGRISFTTPMLWALAFIPNFVIGGV TGVMLAMAAADYQYHNTYFLVSHFHYVLIAGTVFACFAGFIFWYPKMFGHKLNERIGK WFFWIFMIGFNICFFPQYFLGLQGMPRRIYTYGPNDGWTTLNFISTVGAFMMGVGFLI LCYNIYYSFRYSTREISGDSWGVGRTLDWATSSAIPPHYNFAVLPEVKSQDAFLHMKE EKTELYPESKFKKIHMPSNSGRPFFMSVAFGLAGFGLVFEWYWMGVVGLIGVLLCMVL RSFEYDNGYYISVDEIKETERKISE*" /label="qoxB CDS" gene complement(3566434..3568383) /gene="qoxB" /locus_tag="BSU_38160" /old_locus_tag="BSU38160" /label="qoxB gene" misc_feature 3567647..3567666 /Source="Nicolas_upshift_promotors" /id="U2998" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.869130869130869" /psig="0.894105894105894" /xcortree=62 /SigmaFactorBS="gcttccaatgtgaaaaagtgagcgccgaacaaacgatcaaat gataaaagtgctAATGCTACTGTAAGTACAGGgaacgcaaacacgataataaccattg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3567653 /Source="Nicolas_upshifts" /id="U2998" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.869130869130869" /psig="0.894105894105894" /xcortree=62 /SigmaFactorBS="gcttccaatgtgaaaaagtgagcgccgaacaaacgatcaaat gataaaagtgctAATGCTACTGTAAGTACAGGgaacgcaaacacgataataaccattg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_no_box 3568077..3568177 /Source="Nicolas_upshift_promotors" /id="U2999" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.915084915084915" /psig="0.002997002997003" /xcortree=78 /SigmaFactorBS="cgtgagttgtaaaaatttcattatagtggtttgagtctaaaa aactgttattcggaagcgctagctgggcacgcatcatcagaccgtcgacaccgccacg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts 3568137 /Source="Nicolas_upshifts" /id="U2999" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.915084915084915" /psig="0.002997002997003" /xcortree=78 /SigmaFactorBS="cgtgagttgtaaaaatttcattatagtggtttgagtctaaaa aactgttattcggaagcgctagctgggcacgcatcatcagaccgtcgacaccgccacg g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 3568247 /Source="Nicolas_upshifts" /id="D1974" /incds=1 /nref=1 /ntot=73 /MaxReadThrough="3.07388" /MaxDrop="3.44223" /score="-7.14620582" /energy="-8.1" /TU="U2999" /idTUdmin="U2999" /TUdmin="-154" /isTUend="FALSE" /label="downshifts" CDS complement(3568411..3569376) /gene="qoxA" /locus_tag="BSU_38170" /old_locus_tag="BSU38170" /EC_number="1.10.3.12" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:1316894, 7495838, 7575098, 10551842, 22720735, 26196462" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1316894, 7495838, 7575098, 10551842, 22720735, 26196462; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="cytochrome aa3-600 quinol oxidase (subunit II)" /protein_id="NP_391696.2" /db_xref="EnsemblGenomes-Gn:BSU38170" /db_xref="EnsemblGenomes-Tr:CAB15843" /db_xref="GOA:P34957" /db_xref="InterPro:IPR002429" /db_xref="InterPro:IPR006332" /db_xref="InterPro:IPR006333" /db_xref="InterPro:IPR008972" /db_xref="InterPro:IPR011759" /db_xref="InterPro:IPR034227" /db_xref="InterPro:IPR036257" /db_xref="SubtiList:BG10583" /db_xref="UniProtKB/Swiss-Prot:P34957" /translation="MIFLFRALKPLLVLALLTVVFVLGGCSNASVLDPKGPVAEQQSD LILLSIGFMLFIVGVVFVLFTIILVKYRDRKGKDNGSYNPEIHGNTFLEVVWTVIPIL IVIALSVPTVQTIYSLEKAPEATKDKEPLVVYATSVDWKWVFSYPEQDIETVNYLNIP VDRPILFKISSADSMASLWIPQLGGQKYAMAGMLMDQYLQADKVGTYEGRNANFTGEH FADQEFDVNAVTEKDFNSWVKKTQNEAPKLTKEKYDELMLPENVDELTFSSTHLKYVD HGQDAEYAMEARKRLGYQAVSPHSKTDPFENVKKNEFKKSDDTEE*" /label="qoxA CDS" gene complement(3568411..3569376) /gene="qoxA" /locus_tag="BSU_38170" /old_locus_tag="BSU38170" /label="qoxA gene" S_feature complement(3569377..3569445) /Source="Nicolas_S_feature" /locus_tag="new_3918262_3918330_c" /HighExp="M0t90, M40t90, Lbtran, Lbstat, M40t45, S2, nit, ferm, LBGstat, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA, SigEF" /TUshortPSig="0.626, 1, 1, 0.95" /TUlongSig="NA" /TUlongPSig="NA" /label="S1471" promotor_-10 complement(3569432..3569451) /Source="Nicolas_upshift_promotors" /id="U3000" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.30969030969031" /psig="0.626373626373626" /xcortree=2709 /SigmaFactorBS="taagcgaaaatgggatgaagtttataaaaaaataaagCTAAT aagtgaagttttTGATAGCATAACAAAGTAGAgaaaagattttgaggaagtatgcact t" /listShort="S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3569445) /Source="Nicolas_upshifts" /id="U3000" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.30969030969031" /psig="0.626373626373626" /xcortree=2709 /SigmaFactorBS="taagcgaaaatgggatgaagtttataaaaaaataaagCTAAT aagtgaagttttTGATAGCATAACAAAGTAGAgaaaagattttgaggaagtatgcact t" /listShort="S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3569447..3569632) /Source="Nicolas_S_feature" /locus_tag="new_3918332_3918517_c" /HighExp="LBGstat, Heat, G150, G135, LBGtran, G180, BMM, Salt, LBGexp, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigEF" /TUshortPSig="1, 1, 0.95" /TUlongSig="NA" /TUlongPSig="NA" /label="S1472" promotor_-35 complement(3569464..3569468) /Source="Nicolas_upshift_promotors" /id="U3000" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.30969030969031" /psig="0.626373626373626" /xcortree=2709 /SigmaFactorBS="taagcgaaaatgggatgaagtttataaaaaaataaagCTAAT aagtgaagttttTGATAGCATAACAAAGTAGAgaaaagattttgaggaagtatgcact t" /listShort="S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3569563..3569568 /Source="Nicolas_upshift_promotors" /id="U3001" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.903096903096903" /psig="0.903096903096903" /xcortree=792 /SigmaFactorBS="tgctccaactttattcacatctatcgcttaagatGAAAAGtt tctagttatttccGCATATAAAGTAAAGAAAGatgatgaagaactaattctgacaaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3569584..3569602 /Source="Nicolas_upshift_promotors" /id="U3001" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.903096903096903" /psig="0.903096903096903" /xcortree=792 /SigmaFactorBS="tgctccaactttattcacatctatcgcttaagatGAAAAGtt tctagttatttccGCATATAAAGTAAAGAAAGatgatgaagaactaattctgacaaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3569589 /Source="Nicolas_upshifts" /id="U3001" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.903096903096903" /psig="0.903096903096903" /xcortree=792 /SigmaFactorBS="tgctccaactttattcacatctatcgcttaagatGAAAAGtt tctagttatttccGCATATAAAGTAAAGAAAGatgatgaagaactaattctgacaaat t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3569623..3569642) /Source="Nicolas_upshift_promotors" /id="U3002" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=2699 /SigmaFactorBS="atctagaaagtttaacaaaatgaaatttttgATTGAcctaag ttttttatTGTGGTAAACCTTAATTTGTcagaattagttcttcatcatctttctttac t" /listShort="S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3569632) /Source="Nicolas_upshifts" /id="U3002" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=2699 /SigmaFactorBS="atctagaaagtttaacaaaatgaaatttttgATTGAcctaag ttttttatTGTGGTAAACCTTAATTTGTcagaattagttcttcatcatctttctttac t" /listShort="S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3569634..3569743) /Source="Nicolas_S_feature" /locus_tag="new_3918519_3918628_c" /HighExp="Heat, Salt, LBGstat, BMM, Oxctl, H2O2, MG 15, UNK1, MG-0.1, MG 25" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="1, 0.95" /TUlongSig="NA" /TUlongPSig="NA" /label="S1473" promotor_-35 complement(3569657..3569661) /Source="Nicolas_upshift_promotors" /id="U3002" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.583416583416583" /psig=1 /xcortree=2699 /SigmaFactorBS="atctagaaagtttaacaaaatgaaatttttgATTGAcctaag ttttttatTGTGGTAAACCTTAATTTGTcagaattagttcttcatcatctttctttac t" /listShort="S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3569699 /Source="Nicolas_upshifts" /id="D1975" /incds=0 /nref=3 /ntot=21 /MaxReadThrough="2.69533" /MaxDrop="4.01393" /score="13.5410442" /energy="-16.4" /TU="U3001" /idTUdmin="U3001" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3569728..3569747) /Source="Nicolas_upshift_promotors" /id="U3003" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2528 /SigmaFactorBS="tacggacaattcagagcatattggctcttcattgcgCCTTTt ctttcaatatttgaTGCGTTAAAATGGTAACCGTgtgaaaagatgctagacgaggaaa a" /listShort="S1473, S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3569743) /Source="Nicolas_upshifts" /id="U3003" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2528 /SigmaFactorBS="tacggacaattcagagcatattggctcttcattgcgCCTTTt ctttcaatatttgaTGCGTTAAAATGGTAACCGTgtgaaaagatgctagacgaggaaa a" /listShort="S1473, S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3569763..3569767) /Source="Nicolas_upshift_promotors" /id="U3003" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.987012987012987" /psig=1 /xcortree=2528 /SigmaFactorBS="tacggacaattcagagcatattggctcttcattgcgCCTTTt ctttcaatatttgaTGCGTTAAAATGGTAACCGTgtgaaaagatgctagacgaggaaa a" /listShort="S1473, S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3569821..3569839) /Source="Nicolas_upshift_promotors" /id="U3004" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.95004995004995" /psig="0.95004995004995" /xcortree=1019 /SigmaFactorBS="aactcatcatgcaacacatcctattttttatttatttgCTTA TAtcattcctcttttttGTATAAGATAAACAACTGGatgctctcataaaaaaatacgg a" /listShort="S1473, S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 3569826..3569832 /Source="Nicolas_upshift_promotors" /id="U3005" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=241 /SigmaFactorBS="ctgaattgtccgtatttttttatgagagcatccagtTGTTTA TcttatacaaaaaagAGGAATGATATAAGCAAATaaataaaaaataggatgtgttgca t" /listShort="ywzA" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3569838) /Source="Nicolas_upshifts" /id="U3004" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.95004995004995" /psig="0.95004995004995" /xcortree=1019 /SigmaFactorBS="aactcatcatgcaacacatcctattttttatttatttgCTTA TAtcattcctcttttttGTATAAGATAAACAACTGGatgctctcataaaaaaatacgg a" /listShort="S1473, S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3569847..3569865 /Source="Nicolas_upshift_promotors" /id="U3005" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=241 /SigmaFactorBS="ctgaattgtccgtatttttttatgagagcatccagtTGTTTA TcttatacaaaaaagAGGAATGATATAAGCAAATaaataaaaaataggatgtgttgca t" /listShort="ywzA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3569850 /Source="Nicolas_upshifts" /id="U3005" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=241 /SigmaFactorBS="ctgaattgtccgtatttttttatgagagcatccagtTGTTTA TcttatacaaaaaagAGGAATGATATAAGCAAATaaataaaaaataggatgtgttgca t" /listShort="ywzA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3569855..3569860) /Source="Nicolas_upshift_promotors" /id="U3004" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.95004995004995" /psig="0.95004995004995" /xcortree=1019 /SigmaFactorBS="aactcatcatgcaacacatcctattttttatttatttgCTTA TAtcattcctcttttttGTATAAGATAAACAACTGGatgctctcataaaaaaatacgg a" /listShort="S1473, S1472, S1471, qoxA, qoxB, qoxC, qoxD" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3569892..3570137 /gene="ywzA" /locus_tag="BSU_38180" /old_locus_tag="BSU38180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391697.2" /db_xref="EnsemblGenomes-Gn:BSU38180" /db_xref="EnsemblGenomes-Tr:CAB15844" /db_xref="GOA:O32282" /db_xref="InterPro:IPR007341" /db_xref="SubtiList:BG14162" /db_xref="UniProtKB/Swiss-Prot:O32282" /translation="MSFLISLIVAIIIGWLGSLFVKGDMPGGIIGSMIAGLIGAWIGH GLLGTWGPHLAGFAIIPAVIGAAIVVFLVSLLTRKRG*" /label="ywzA CDS" gene 3569892..3570137 /gene="ywzA" /locus_tag="BSU_38180" /old_locus_tag="BSU38180" /label="ywzA gene" downshifts 3570119 /Source="Nicolas_upshifts" /id="D1976" /incds=0 /nref=125 /ntot=189 /MaxReadThrough="2.63086" /MaxDrop="7.72876" /score="13.5410442" /energy="-16.4" /TU="NA" /idTUdmin="U3005" /TUdmin=1 /isTUend="TRUE" /label="downshifts" CDS complement(3570208..3571749) /gene="galT" /locus_tag="BSU_38190" /old_locus_tag="BSU38190" /EC_number="2.7.7.12" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:2104611, 9555917, 11790749" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2104611, 9555917, 11790749; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="galactose-1-phosphate uridyltransferase" /protein_id="NP_391698.2" /db_xref="EnsemblGenomes-Gn:BSU38190" /db_xref="EnsemblGenomes-Tr:CAB15845" /db_xref="GOA:P39575" /db_xref="InterPro:IPR000766" /db_xref="InterPro:IPR005849" /db_xref="InterPro:IPR005850" /db_xref="InterPro:IPR023425" /db_xref="SubtiList:BG10582" /db_xref="UniProtKB/Swiss-Prot:P39575" /translation="MSIIEHLEQLLEYGLERKLISIWDREYTRNRLYEALGITHPEPN SSTSIKQSQSLPDLLAPIYKWAAETGRMEADTDTYRDLLSAKLMGCFVPAPSEVIRKF EETKALYGPKQATKEFYQYSEDVYYIRTDRIAKNVHWTVPTEYGELEMTINLSKPEKD PKAIAAAKEQEQTNYPMCLLCKENVGFEGSVNHPARQNHRIIPVILEDEQWFLQFSPY VYYPEHCIVLKGEHEPMEISKKTFERLLSFLGQYPHYFIGSNADLPIVGGSILSHDHF QGGAHDFPMARAEAEDVYELNDYPGVSLGLVKWPMSVLRLQGDEPGHVAEAADHIFRT WQTYSDEKAGIAAYTGDTPHNTVTPIARRRGDLYELDIVLRNNRTDEEHPLGIFHPHQ EVHHIKKENIGLIEVMGLAILPGRLQEEMKETAAALCSADPKTALEQNPLTAKHSEWA LRTMEKRTITKENVDLVIKEELGHVFARILEHAGVFKQTAEGKQAFRRFIDQLGAKPV KSLNR*" /label="galT CDS" gene complement(3570208..3571749) /gene="galT" /locus_tag="BSU_38190" /old_locus_tag="BSU38190" /label="galT gene" downshifts complement(3570237) /Source="Nicolas_upshifts" /id="D1977" /incds=0 /nref=190 /ntot=254 /MaxReadThrough="0.3431" /MaxDrop="6.63153" /score="21.0691542" /energy="-14.7" /TU="NA" /idTUdmin="U3006" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3571753..3572925) /gene="galK" /locus_tag="BSU_38200" /old_locus_tag="BSU38200" /EC_number="2.7.1.6" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:2104611, 9555917" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 2104611, 9555917; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="galactokinase" /protein_id="NP_391699.1" /db_xref="EnsemblGenomes-Gn:BSU38200" /db_xref="EnsemblGenomes-Tr:CAB15846" /db_xref="GOA:P39574" /db_xref="InterPro:IPR000705" /db_xref="InterPro:IPR006203" /db_xref="InterPro:IPR006204" /db_xref="InterPro:IPR006206" /db_xref="InterPro:IPR013750" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR019539" /db_xref="InterPro:IPR019741" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR022963" /db_xref="InterPro:IPR036554" /db_xref="SubtiList:BG10581" /db_xref="UniProtKB/Swiss-Prot:P39574" /translation="MREELKGIFASVFGEKEGLRFFFAPGRVNLIGEHTDYNGGHVFP CALTMGTYAAVAERNDGLVRMYSDNFRNAGIKECSLDDIRYQKEDDWANYPKGVIYEF QQRGYAVPHGFDIVFSGNIPNGAGLSSSASIELLMGVVLQSYFHPEVDALELVKMAQH AENHFIGVNCGIMDQFAIGMGKKHHAMLLNCDTLDYEYSKLNVSGLALVIANTNKKRT LADSSYNTRRQECNDALLDLKKGLDIAALGDIKPSDFDAHSSLIQNETNRRRAKHAVY ENHRAIKTAHMFKENNIDEIGQLMKESHLSLKDDYEVTCPELDELVFAAWDHEGVIGS RMTGAGFGGCTISIVKDEFVDDFIQKVGDRYQEKTGLRADFYVADIGEGARELKGE*" /label="galK CDS" gene complement(3571753..3572925) /gene="galK" /locus_tag="BSU_38200" /old_locus_tag="BSU38200" /label="galK gene" promotor_-10 complement(3572943..3572961) /Source="Nicolas_upshift_promotors" /id="U3006" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=170 /SigmaFactorBS="caaaagaagaaggggtatgagaggactgcagcatatgatctg cCGTTTTCtatgaagaaataagGGGAATAAAAAATAAAAACcagaaaggtgattgcac a" /listShort="galK, galT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3572965) /Source="Nicolas_upshifts" /id="U3006" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=170 /SigmaFactorBS="caaaagaagaaggggtatgagaggactgcagcatatgatctg cCGTTTTCtatgaagaaataagGGGAATAAAAAATAAAAACcagaaaggtgattgcac a" /listShort="galK, galT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3572976..3572982) /Source="Nicolas_upshift_promotors" /id="U3006" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=170 /SigmaFactorBS="caaaagaagaaggggtatgagaggactgcagcatatgatctg cCGTTTTCtatgaagaaataagGGGAATAAAAAATAAAAACcagaaaggtgattgcac a" /listShort="galK, galT" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3573006..3573389) /gene="ywcD" /locus_tag="BSU_38210" /old_locus_tag="BSU38210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9882654, 15849754, 16850406, 18192405; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative cell wall glycosylation protein" /protein_id="NP_391700.1" /db_xref="EnsemblGenomes-Gn:BSU38210" /db_xref="EnsemblGenomes-Tr:CAB15847" /db_xref="GOA:P39602" /db_xref="InterPro:IPR007267" /db_xref="SubtiList:BG10580" /db_xref="UniProtKB/Swiss-Prot:P39602" /translation="MYIIMGVFTTIVNIASFYILVEIMNVDYKAATVAAWILSVLFAY ITNKLYVFQQKTHDLQSLLKELTAFFSVRVLSLGIDLGMMIILVGQFNTNETLAKILD NAVIVVVNYVASKWLVFKKTKEEGV*" /label="ywcD CDS" gene complement(3573006..3573389) /gene="ywcD" /locus_tag="BSU_38210" /old_locus_tag="BSU38210" /label="ywcD gene" CDS complement(3573407..3574078) /gene="slrC" /locus_tag="BSU_38220" /old_locus_tag="BSU38220" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:18647168" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18647168; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of slrA (biofilm formation)" /protein_id="NP_391701.2" /db_xref="EnsemblGenomes-Gn:BSU38220" /db_xref="EnsemblGenomes-Tr:CAB15848" /db_xref="GOA:P39601" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036271" /db_xref="SubtiList:BG10579" /db_xref="UniProtKB/Swiss-Prot:P39601" /translation="MKKNKFQIKREATFESFIDAGVNLLIDRAYDPVSVEDISRAAGY SKGAFYVHFVSKDDFLLYLLEKRQMKKKIIIGYLDQMERESVKSLTLDEAAKHAAELL YSYYINKPSWDITSFAMNMPTYKVLKKCKAYVRLYELWVEENVLYIKWLKERKLIDAC IDPEYTAKIICAVLDGIIKQSYVLGQPATFRSFLDALSVFFTLDREHERPRILKSFSE SEEHQ*" /label="slrC CDS" gene complement(3573407..3574078) /gene="slrC" /locus_tag="BSU_38220" /old_locus_tag="BSU38220" /label="slrC gene" promotor_-10 complement(3574100..3574119) /Source="Nicolas_upshift_promotors" /id="U3007" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.715284715284715" /psig="0.987012987012987" /xcortree=2081 /SigmaFactorBS="aaccgaatagcataaccgtttaaagaaataaATACcgctaaa gattgatcCGGTGTAAGATAAGGGTAATcattaccgccaggagaaaaatatgaaaaaa a" /listShort="ywcC, ywcD, galK, galT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3574109) /Source="Nicolas_upshifts" /id="U3007" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.715284715284715" /psig="0.987012987012987" /xcortree=2081 /SigmaFactorBS="aaccgaatagcataaccgtttaaagaaataaATACcgctaaa gattgatcCGGTGTAAGATAAGGGTAATcattaccgccaggagaaaaatatgaaaaaa a" /listShort="ywcC, ywcD, galK, galT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3574135..3574138) /Source="Nicolas_upshift_promotors" /id="U3007" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.715284715284715" /psig="0.987012987012987" /xcortree=2081 /SigmaFactorBS="aaccgaatagcataaccgtttaaagaaataaATACcgctaaa gattgatcCGGTGTAAGATAAGGGTAATcattaccgccaggagaaaaatatgaaaaaa a" /listShort="ywcC, ywcD, galK, galT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3574219..3574222 /Source="Nicolas_upshift_promotors" /id="U3008" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.518481518481518" /psig="0.996003996003996" /xcortree=3106 /SigmaFactorBS="taataggctaaatgatttattttcatttacataCTATccagt cagtatttaATTGTTTATTATTATAAATAaggtccattggttatattagtcatttttt t" /listShort="S1474, slrA, S1475, ywcB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3574237..3574256 /Source="Nicolas_upshift_promotors" /id="U3008" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.518481518481518" /psig="0.996003996003996" /xcortree=3106 /SigmaFactorBS="taataggctaaatgatttattttcatttacataCTATccagt cagtatttaATTGTTTATTATTATAAATAaggtccattggttatattagtcatttttt t" /listShort="S1474, slrA, S1475, ywcB" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3574246..3574433 /Source="Nicolas_S_feature" /locus_tag="new_3923131_3923318" /HighExp="T0.30H, T1.0H, Cold, T1.30H, HiOs, T-0.40H, T2.0H, T2.30H, T4.0H, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1474" upshifts 3574246 /Source="Nicolas_upshifts" /id="U3008" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.518481518481518" /psig="0.996003996003996" /xcortree=3106 /SigmaFactorBS="taataggctaaatgatttattttcatttacataCTATccagt cagtatttaATTGTTTATTATTATAAATAaggtccattggttatattagtcatttttt t" /listShort="S1474, slrA, S1475, ywcB" /GFF_Attribute="listLong" /label="upshifts" CDS 3574434..3574592 /gene="slrA" /locus_tag="BSU_38229" /old_locus_tag="BSU38229" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:18647168, 26857544" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 18647168, 26857544; Product type r: regulator" /codon_start=1 /transl_table=11 /product="anti-repressor of SlrR" /protein_id="YP_003097794.1" /db_xref="EnsemblGenomes-Gn:BSU38229" /db_xref="EnsemblGenomes-Tr:CAX52707" /db_xref="GOA:P0C8M5" /db_xref="InterPro:IPR010981" /db_xref="InterPro:IPR036281" /db_xref="UniProtKB/Swiss-Prot:P0C8M5" /translation="MKTHVKKDLDKGWHMLIQEARSIGLGIHDVRQFLESETASRKKN HKKTVRQD*" /label="slrA CDS" gene 3574434..3574592 /gene="slrA" /locus_tag="BSU_38229" /old_locus_tag="BSU38229" /label="slrA gene" S_feature 3574593..3574977 /Source="Nicolas_S_feature" /locus_tag="new_3923478_3923862" /HighExp="T0.30H, Cold, T1.30H, T2.0H, T1.0H, HiOs, T2.30H, T3.0H, LBGstat, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1475" promotor_-35 3574958..3574963 /Source="Nicolas_upshift_promotors" /id="U3009" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1051 /SigmaFactorBS="acgacttccttcttttttcatcctccagctattgtacaaCGC ATAaatcggactttcagtACATACCTATTGGTGTACCtttttgcttacgtttagcgaa t" /listShort="ywcB, ywcA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3574979..3574997 /Source="Nicolas_upshift_promotors" /id="U3009" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1051 /SigmaFactorBS="acgacttccttcttttttcatcctccagctattgtacaaCGC ATAaatcggactttcagtACATACCTATTGGTGTACCtttttgcttacgtttagcgaa t" /listShort="ywcB, ywcA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3574979 /Source="Nicolas_upshifts" /id="U3009" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1051 /SigmaFactorBS="acgacttccttcttttttcatcctccagctattgtacaaCGC ATAaatcggactttcagtACATACCTATTGGTGTACCtttttgcttacgtttagcgaa t" /listShort="ywcB, ywcA" /GFF_Attribute="listLong" /label="upshifts" CDS 3575035..3575343 /gene="vbfB" /locus_tag="BSU_38230" /old_locus_tag="BSU38230" /function="16.1: Circulate" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:26060272, 28357266" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 26060272, 28357266; Product type t: transporter" /codon_start=1 /transl_table=11 /product="subunit of acetate transporter as a volatile signal for biofilm formation" /protein_id="NP_391702.1" /db_xref="EnsemblGenomes-Gn:BSU38230" /db_xref="EnsemblGenomes-Tr:CAB15849" /db_xref="GOA:P39600" /db_xref="InterPro:IPR007436" /db_xref="SubtiList:BG10578" /db_xref="UniProtKB/Swiss-Prot:P39600" /translation="MYKADYKQIAATPSFQAFLKQKRAFIVPSAIFFFVFYFSLPVLT SYFTFLNAPAIGAVSWAWLFAIAQFAMTWILSTVYSRRAAHFDKYVSALKEDLKGEQT *" /label="vbfB CDS" gene 3575035..3575343 /gene="vbfB" /locus_tag="BSU_38230" /old_locus_tag="BSU38230" /label="vbfB gene" downshifts complement(3575121) /Source="Nicolas_upshifts" /id="D1978" /incds=1 /nref=3 /ntot=15 /MaxReadThrough="0.42282" /MaxDrop="5.4957" /score="10.1452497" /energy="-8.3" /TU="NA" /idTUdmin="U3010" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_no_box complement(3575125..3575225) /Source="Nicolas_upshift_promotors" /id="U3010" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.731268731268731" /psig="0.017982017982018" /xcortree=279 /SigmaFactorBS="aacagccaagcccatgaaacagctccaatggccggtgcattc aaaaaggtgaaataagatgtcaaaacagggagtgaaaaataaaaaacaaaaaagaaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(3575165) /Source="Nicolas_upshifts" /id="U3010" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.731268731268731" /psig="0.017982017982018" /xcortree=279 /SigmaFactorBS="aacagccaagcccatgaaacagctccaatggccggtgcattc aaaaaggtgaaataagatgtcaaaacagggagtgaaaaataaaaaacaaaaaagaaaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 3575340..3576881 /gene="vbfA" /locus_tag="BSU_38240" /old_locus_tag="BSU38240" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 26060272, 28357266" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 26060272, 28357266; Product type t: transporter" /codon_start=1 /transl_table=11 /product="acetate Na+-dependent symporter subunit involvedin volatile signal for biofilm formation" /protein_id="NP_391703.2" /db_xref="EnsemblGenomes-Gn:BSU38240" /db_xref="EnsemblGenomes-Tr:CAB15850" /db_xref="GOA:P39599" /db_xref="InterPro:IPR001734" /db_xref="InterPro:IPR018212" /db_xref="SubtiList:BG10577" /db_xref="UniProtKB/Swiss-Prot:P39599" /translation="MNMTAFLLFLAIVGLTLIITYFAAKRTKTTSEFYTAGGGLTGVQ NGLAIAGDYMSAASFLGIAGMIALYGFDGFFYSIGFLVAYLVVLYIVAEPLRNLGKYT MADMIAARFKEKKIRGVAALNTIAISTFYMIAQLVGAGALIKLLLGLDYTAAVLIVGV LMTIYVVFGGMIATSWVQIIKAVLLMAGTLVISIIVFSKFGFSLNTMFEQMKTATPLG ADFLNPGNKYKVPLETLSLNLALVLGTAGLPHILIRFYTVKDAKTARTSVVSATWIIG VFYIMTVFLGFGAAAFVGFDAITAADQAGNMAAPLLAKALGGDFLFAFVSAIAFATIL AVVTGLVLSAASAFAHDIYSQIIRKGEATEKEQMKAARWASVAVSVLSILLAIFAQSL NVAFLVALAFAVAASANLPLIVFTVFWKRFNASGALWGSLTGLISALVLVSMSPSVWD PAGGAIFTGDPLIPLSNPGIISIPLGFLGAWLGTVLSSDKTIDEDTFAEIQVKAHTGV HMEQE*" /label="vbfA CDS" gene 3575340..3576881 /gene="vbfA" /locus_tag="BSU_38240" /old_locus_tag="BSU38240" /label="vbfA gene" downshifts 3576872 /Source="Nicolas_upshifts" /id="D1979" /incds=0 /nref=4 /ntot=35 /MaxReadThrough="2.40129" /MaxDrop="4.15104" /score="2.66606932" /energy="-7.8" /TU="NA" /idTUdmin="U3009" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3576912..3577514) /gene="ywbO" /locus_tag="BSU_38250" /old_locus_tag="BSU38250" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sulfur oxido-reductase" /protein_id="NP_391704.1" /db_xref="EnsemblGenomes-Gn:BSU38250" /db_xref="EnsemblGenomes-Tr:CAB15851" /db_xref="GOA:P39598" /db_xref="InterPro:IPR001853" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG10576" /db_xref="UniProtKB/Swiss-Prot:P39598" /translation="MTVHIKVYSDYVCPFCFVGKAAFEEAIKGKDVEVEWMPFELRPS PSPQLDPVNDPSKQYMWQTSIQPMAEKLGVEINFPNVSPHPYTDLAFEGFHFAKEYNK GHEYNTRVFQAFFQEDQNIGDIDILTKLAEEVGLDGASFKSALETRTYQDVQRQALKH AYEEADITAVPTFIIGDTVIPGAAGKDVFEKAISDEQKKK*" /label="ywbO CDS" gene complement(3576912..3577514) /gene="ywbO" /locus_tag="BSU_38250" /old_locus_tag="BSU38250" /label="ywbO gene" downshifts complement(3576926) /Source="Nicolas_upshifts" /id="D1980" /incds=0 /nref=12 /ntot=123 /MaxReadThrough="1.89374" /MaxDrop="3.51247" /score="21.9354981" /energy="-7.8" /TU="NA" /idTUdmin="U3011" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(3577515..3577796) /Source="Nicolas_S_feature" /locus_tag="new_3926400_3926681_c" /HighExp="T1.0H, G135, G150, T1.30H, Lbexp, G180, Lbstat, dia5, LBGexp, M0t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.984, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1476" CDS complement(3577797..3579047) /gene="efeB" /locus_tag="BSU_38260" /old_locus_tag="BSU38260" /EC_number="1.11.1.-" /function="16.11: Scavenge (Catabolism)" /function="16.2: Construct biomass (Anabolism)" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 15554971, 16672620, 16987175, 18931290, 19383693, 21479178, 23764491, 24620988, 27795321" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15554971, 16672620, 16987175, 18931290, 19383693, 21479178, 23764491, 24620988, 27795321; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peroxidase converting ferric iron into ferrous iron" /protein_id="NP_391705.1" /db_xref="EnsemblGenomes-Gn:BSU38260" /db_xref="EnsemblGenomes-Tr:CAB15852" /db_xref="GOA:P39597" /db_xref="InterPro:IPR006311" /db_xref="InterPro:IPR006313" /db_xref="InterPro:IPR006314" /db_xref="InterPro:IPR011008" /db_xref="InterPro:IPR019546" /db_xref="SubtiList:BG10575" /db_xref="UniProtKB/Swiss-Prot:P39597" /translation="MSDEQKKPEQIHRRDILKWGAMAGAAVAIGASGLGGLAPLVQTA AKPSKKDEKEEEQIVPFYGKHQAGITTAHQTYVYFAALDVTAKDKSDIITLFRNWTSL TQMLTSGKKMSAEQRNQYLPPQDTGESADLSPSNLTVTFGFGPGFFEKDGKDRFGLKS KKPKHLAALPAMPNDNLDEKQGGGDICIQVCADDEQVAFHALRNLLNQAVGTCEVRFV NKGFLSGGKNGETPRNLFGFKDGTGNQSTKDDTLMNSIVWIQSGEPDWMTGGTYMAFR KIKMFLEVWDRSSLKDQEDTFGRRKSSGAPFGQKKETDPVKLNQIPSNSHVSLAKSTG KQILRRAFSYTEGLDPKTGYMDAGLLFISFQKNPDNQFIPMLKALSAKDALNEYTQTI GSALYACPGGCKKGEYIAQRLLES*" /label="efeB CDS" gene complement(3577797..3579047) /gene="efeB" /locus_tag="BSU_38260" /old_locus_tag="BSU38260" /label="efeB gene" downshifts complement(3577893) /Source="Nicolas_upshifts" /id="D1981" /incds=1 /nref=67 /ntot=232 /MaxReadThrough="5.0552" /MaxDrop="3.65898" /score="21.9354981" /energy="-7.8" /TU="U3011,U3012" /idTUdmin="U3011" /TUdmin="-967" /isTUend="FALSE" /label="downshifts" CDS complement(3579066..3580223) /gene="efeM" /locus_tag="BSU_38270" /old_locus_tag="BSU38270" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 15849754, 16672620, 16850406, 16987175, 23764491, 27795321" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15849754, 16672620, 16850406, 16987175, 23764491, 27795321; Product type t: transporter" /codon_start=1 /transl_table=11 /product="lipoprotein binding ferrous or ferric iron for transport" /protein_id="NP_391706.1" /db_xref="EnsemblGenomes-Gn:BSU38270" /db_xref="EnsemblGenomes-Tr:CAB15853" /db_xref="GOA:P39596" /db_xref="InterPro:IPR018976" /db_xref="InterPro:IPR034981" /db_xref="SubtiList:BG10574" /db_xref="UniProtKB/Swiss-Prot:P39596" /translation="MNFTKIAVSAGCILALCAGCGANDTSSTKEKASSEKSGVTKEIT ASVNKMETIISKLNDSVEKGDQKEIEKKGKELNSYWLSFENDIRSDYPFEYTEIEKHL QPIYTEAQKDKPDAGKIKTESESLKASLEDLTEAKKSGKKASDQLAKAADEYKGYVKE QSDQLVKATEAFTGAVKSGDIEKSKTLYAKARVYYERIEPIAESLGDLDPKIDAREND VEEGDKWTGFHKLEKAIWKDQDISGEKATADQLLKDVKELDGSIQSLKLTPEQIVAGA MELLNEAGISKITGEEERYSRIDLVDLMANVEGSEAVYQTVKSALVKDHSDLTEKLDT EFSEFEVLMAKYKTNDQSYTSYDKLSEKQIRELSTKLTTLSETMSKIANVL*" /label="efeM CDS" gene complement(3579066..3580223) /gene="efeM" /locus_tag="BSU_38270" /old_locus_tag="BSU38270" /label="efeM gene" misc_feature complement(3579139..3579158) /Source="Nicolas_upshift_promotors" /id="U3011" /multdbtbs="SigW,SigX" /comp="M4" /sig="SigA" /pcomp="0.917082917082917" /psig="0.984015984015984" /xcortree=3235 /SigmaFactorBS="atacggagttcagcgaatttgaagttttaatggcaaaataca aaacaaatgatcagtcctatacgtctTATGATAAATTAAGTGAAAAgcaaatcagaga g" /listShort="efeN, S1476, ywbO" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3579166) /Source="Nicolas_upshifts" /id="U3011" /multdbtbs="SigW,SigX" /comp="M4" /sig="SigA" /pcomp="0.917082917082917" /psig="0.984015984015984" /xcortree=3235 /SigmaFactorBS="atacggagttcagcgaatttgaagttttaatggcaaaataca aaacaaatgatcagtcctatacgtctTATGATAAATTAAGTGAAAAgcaaatcagaga g" /listShort="efeN, S1476, ywbO" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3580220..3581665) /gene="efeU" /locus_tag="BSU_38280" /old_locus_tag="BSU38280" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12354229, 15849754, 16672620, 16850406, 16987175, 23764491, 27795321" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12354229, 15849754, 16672620, 16850406, 16987175, 23764491, 27795321; Product type t: transporter" /codon_start=1 /transl_table=11 /product="ferrous ion permease" /protein_id="NP_391707.2" /db_xref="EnsemblGenomes-Gn:BSU38280" /db_xref="EnsemblGenomes-Tr:CAB15854" /db_xref="GOA:P39595" /db_xref="InterPro:IPR004923" /db_xref="SubtiList:BG10573" /db_xref="UniProtKB/Swiss-Prot:P39595" /translation="MARGLALILFSLLMVFGSAAHAEDDPIAALIQLNKQMIKSVKDG DMDSAQQTFDTFKAKWKKEEPSIKKENLSSHSEMDANIAMISLSFINQDARKLKTQLE ELASHLETYQQAVVLKKTSSGQSRASLTAYIQSLKDTKQFIEKKQLDEASSAIDNLVT SWLAVEGDVVSQSKEAYTTSEENLALMKAEIGSHPEKVSKQIDEMIQLLEPIASSSYS WWDAALIPVREGMEALLVIGALLTMTKKARVTRSSTWIWGGASAGMAVSLAAGIGVTV LFSSSVFGENNFLLGGVTGVLSAVMLLYVGVWLHRNASMDKWREKINIQKSQALKKRS LLSFALIAFLAVVREGLETVIFFIGLVGKLPLTELIGGTAAGLIVLVIVGVLMIKLGM RIPLKPFFLLSMAVVLYMCVKFLGTGVHSLQLAGILPSDAESWLPSVSVLGIYPSVYS TIPQMLILLFLLIALVSEAAKHFTNGKELTK*" /label="efeU CDS" gene complement(3580220..3581665) /gene="efeU" /locus_tag="BSU_38280" /old_locus_tag="BSU38280" /label="efeU gene" promotor_-10 complement(3581699..3581718) /Source="Nicolas_upshift_promotors" /id="U3012" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2103 /SigmaFactorBS="tccatcaaggttttcagaccttcaaattttAATTGACAaagg acaggaactGGCTATGATTATGTTATACAatgataatcattttcaattataggaggaa c" /listShort="efeU, efeM, efeN, S1476, ywbO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3581709) /Source="Nicolas_upshifts" /id="U3012" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2103 /SigmaFactorBS="tccatcaaggttttcagaccttcaaattttAATTGACAaagg acaggaactGGCTATGATTATGTTATACAatgataatcattttcaattataggaggaa c" /listShort="efeU, efeM, efeN, S1476, ywbO" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3581732..3581739) /Source="Nicolas_upshift_promotors" /id="U3012" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.98901098901099" /psig=1 /xcortree=2103 /SigmaFactorBS="tccatcaaggttttcagaccttcaaattttAATTGACAaagg acaggaactGGCTATGATTATGTTATACAatgataatcattttcaattataggaggaa c" /listShort="efeU, efeM, efeN, S1476, ywbO" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3581822..3582490) /gene="thiE" /locus_tag="BSU_38290" /old_locus_tag="BSU38290" /EC_number="2.5.1.3" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 10382260, 16291685, 19888457, 22616866; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="thiamine-phosphate pyrophosphorylase (thiamine phosphate synthase)" /protein_id="NP_391708.1" /db_xref="EnsemblGenomes-Gn:BSU38290" /db_xref="EnsemblGenomes-Tr:CAB15855" /db_xref="GOA:P39594" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR022998" /db_xref="InterPro:IPR034291" /db_xref="InterPro:IPR036206" /db_xref="PDB:1G4E" /db_xref="PDB:1G4P" /db_xref="PDB:1G4S" /db_xref="PDB:1G4T" /db_xref="PDB:1G67" /db_xref="PDB:1G69" /db_xref="PDB:1G6C" /db_xref="PDB:2TPS" /db_xref="PDB:3O15" /db_xref="PDB:3O16" /db_xref="SubtiList:BG10572" /db_xref="UniProtKB/Swiss-Prot:P39594" /translation="MTRISREMMKELLSVYFIMGSNNTKADPVTVVQKALKGGATLYQ FREKGGDALTGEARIKFAEKAQAACREAGVPFIVNDDVELALNLKADGIHIGQEDANA KEVRAAIGDMILGVSAHTMSEVKQAEEDGADYVGLGPIYPTETKKDTRAVQGVSLIEA VRRQGISIPIVGIGGITIDNAAPVIQAGADGVSMISAISQAEDPESAARKFREEIQTY KTGR*" /label="thiE CDS" gene complement(3581822..3582490) /gene="thiE" /locus_tag="BSU_38290" /old_locus_tag="BSU38290" /label="thiE gene" downshifts complement(3581831) /Source="Nicolas_upshifts" /id="D1982" /incds=0 /nref=44 /ntot=194 /MaxReadThrough="1.62789" /MaxDrop="4.13196" /score="10.8502035" /energy="-10" /TU="NA" /idTUdmin="U3013" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3582487..3583305) /gene="thiM" /locus_tag="BSU_38300" /old_locus_tag="BSU38300" /EC_number="2.7.1.50" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10382260, 16291685, 22938038, 28729425" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10382260, 16291685, 22938038, 28729425; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5-(2-hydroxyethyl)-4-methylthiazole kinase" /protein_id="NP_391709.1" /db_xref="EnsemblGenomes-Gn:BSU38300" /db_xref="EnsemblGenomes-Tr:CAB15856" /db_xref="GOA:P39593" /db_xref="InterPro:IPR000417" /db_xref="InterPro:IPR029056" /db_xref="PDB:1C3Q" /db_xref="PDB:1EKK" /db_xref="PDB:1EKQ" /db_xref="PDB:1ESJ" /db_xref="PDB:1ESQ" /db_xref="SubtiList:BG10571" /db_xref="UniProtKB/Swiss-Prot:P39593" /translation="MDAQSAAKCLTAVRRHSPLVHSITNNVVTNFTANGLLALGASPV MAYAKEEVADMAKIAGALVLNIGTLSKESVEAMIIAGKSANEHGVPVILDPVGAGATP FRTESARDIIREVRLAAIRGNAAEIAHTVGVTDWLIKGVDAGEGGGDIIRLAQQAAQK LNTVIAITGEVDVIADTSHVYTLHNGHKLLTKVTGAGCLLTSVVGAFCAVEENPLFAA IAAISSYGVAAQLAAQQTADKGPGSFQIELLNKLSTVTEQDVQEWATIERVTVS*" /label="thiM CDS" gene complement(3582487..3583305) /gene="thiM" /locus_tag="BSU_38300" /old_locus_tag="BSU38300" /label="thiM gene" CDS complement(3583313..3584218) /gene="cidR" /locus_tag="BSU_38310" /old_locus_tag="BSU38310" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 23504016; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (LysR family, cidAB expression)" /protein_id="NP_391710.1" /db_xref="EnsemblGenomes-Gn:BSU38310" /db_xref="EnsemblGenomes-Tr:CAB15857" /db_xref="GOA:P39592" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10570" /db_xref="UniProtKB/Swiss-Prot:P39592" /translation="MDIRHLTYFLEVARLKSFTKASQSLYVSQPTISKMIKNLEEELG IELFYRNGRQVELTDAGHSMYVQAQEIIKSFQNLTSELNDIMEVKKGHVRIGLPPMIG SGFFPRVLGDFRENYPNVTFQLVEDGSIKVQEGVGDGSLDIGVVVLPANEDIFHSFTI VKETLMLVVHPSHRLADEKECQLRELKDEPFIFFREDFVLHNRIMTECIKAGFRPHII YETSQWDFISEMVSANLGIGLLPERICRGLDPEKVKVIPLVDPVIPWHLAIIWRKDRY LSFAARAWLEHTKSYLWDPKKDSKG*" /label="cidR CDS" gene complement(3583313..3584218) /gene="cidR" /locus_tag="BSU_38310" /old_locus_tag="BSU38310" /label="cidR gene" misc_feature complement(3583953..3583972) /Source="Nicolas_upshift_promotors" /id="U3013" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.857142857142857" /psig="0.992007992007992" /xcortree=2665 /SigmaFactorBS="tgtgcaggcgcaggaaatcattaaatcatttcaaaacctgac gtcagaattaAATGATATTATGGAAGTCAAgaaagggcacgtacggattggactgccg c" /listShort="thiM, thiE" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3583964) /Source="Nicolas_upshifts" /id="U3013" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.857142857142857" /psig="0.992007992007992" /xcortree=2665 /SigmaFactorBS="tgtgcaggcgcaggaaatcattaaatcatttcaaaacctgac gtcagaattaAATGATATTATGGAAGTCAAgaaagggcacgtacggattggactgccg c" /listShort="thiM, thiE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3584259..3584278) /Source="Nicolas_upshift_promotors" /id="U3014" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig="0.996003996003996" /xcortree=2443 /SigmaFactorBS="agcaacagttttttcatattgatgcctcccttatatactTAT TGTACataaggtctctctatAGGTAAAATATATATTAAGAataagaagtattcctttt g" /listShort="ywbI, thiM, thiE" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 3584269..3584276 /Source="Nicolas_upshift_promotors" /id="U3015" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=2449 /SigmaFactorBS="cctttctatagacaaaaggaatacttcttattcttaatataT ATTTTACctatagagagaccTTATGTACAATAAGTATATAagggaggcatcaatatga a" /listShort="cidA, lrgB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3584280) /Source="Nicolas_upshifts" /id="U3014" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig="0.996003996003996" /xcortree=2443 /SigmaFactorBS="agcaacagttttttcatattgatgcctcccttatatactTAT TGTACataaggtctctctatAGGTAAAATATATATTAAGAataagaagtattcctttt g" /listShort="ywbI, thiM, thiE" /GFF_Attribute="listLong" /label="upshifts" upshifts 3584288 /Source="Nicolas_upshifts" /id="U3015" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=2449 /SigmaFactorBS="cctttctatagacaaaaggaatacttcttattcttaatataT ATTTTACctatagagagaccTTATGTACAATAAGTATATAagggaggcatcaatatga a" /listShort="cidA, lrgB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3584290..3584309 /Source="Nicolas_upshift_promotors" /id="U3015" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.845154845154845" /psig=1 /xcortree=2449 /SigmaFactorBS="cctttctatagacaaaaggaatacttcttattcttaatataT ATTTTACctatagagagaccTTATGTACAATAAGTATATAagggaggcatcaatatga a" /listShort="cidA, lrgB" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3584294..3584301) /Source="Nicolas_upshift_promotors" /id="U3014" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.531468531468531" /psig="0.996003996003996" /xcortree=2443 /SigmaFactorBS="agcaacagttttttcatattgatgcctcccttatatactTAT TGTACataaggtctctctatAGGTAAAATATATATTAAGAataagaagtattcctttt g" /listShort="ywbI, thiM, thiE" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3584324..3584710 /gene="cidA" /locus_tag="BSU_38320" /old_locus_tag="BSU38320" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15659658, 15849754, 16850406, 22383849, 26060272; Product type r: regulator" /codon_start=1 /transl_table=11 /product="metabolic regulator of murein hydrolases" /protein_id="NP_391711.1" /db_xref="EnsemblGenomes-Gn:BSU38320" /db_xref="EnsemblGenomes-Tr:CAB15858" /db_xref="GOA:P39591" /db_xref="InterPro:IPR005538" /db_xref="InterPro:IPR023760" /db_xref="SubtiList:BG10569" /db_xref="UniProtKB/Swiss-Prot:P39591" /translation="MKKLLLTVIQIALLFIFARLINWVTALLHINIPGSIIGIVILFT LLHFNIIKLEWIELGAAWLLGELLLFFIPSAVGVIEYGDIMSKFGVSILLVVIISTFV VMVSTGTLTQLIAKRKEKKHTCSSEL*" /label="cidA CDS" gene 3584324..3584710 /gene="cidA" /locus_tag="BSU_38320" /old_locus_tag="BSU38320" /label="cidA gene" CDS 3584692..3585369 /gene="cidB" /locus_tag="BSU_38330" /old_locus_tag="BSU38330" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15659658, 15849754, 16850406, 26060272; Product type r: regulator" /codon_start=1 /transl_table=11 /product="metabolic regulator controlling activity of murein hydrolases" /protein_id="NP_391712.2" /db_xref="EnsemblGenomes-Gn:BSU38330" /db_xref="EnsemblGenomes-Tr:CAB15859" /db_xref="GOA:P39590" /db_xref="InterPro:IPR005261" /db_xref="InterPro:IPR007300" /db_xref="SubtiList:BG10568" /db_xref="UniProtKB/Swiss-Prot:P39590" /translation="MFIGIVSLFLTVLVYLGAKKVYQRFPRVYTSPLLVTPAVLVGLL LLVNVPYESYNLGGGLLTDMLQPATVAFAIPLYKYFPVLKKYAVEIILNVAVGSCIAI ISTALIAKWLHLGTGLIDSLVPRSVTTPIAMNVSEMIGGMPAVTAVFVILTALLGTVI GPMVIRYFRIDNEIARGVLLGTSAHGAGTSKAFELSSVSGTISSVSMILAAIMTLCAA PFLLSFM*" /label="cidB CDS" gene 3584692..3585369 /gene="cidB" /locus_tag="BSU_38330" /old_locus_tag="BSU38330" /label="cidB gene" downshifts 3585341 /Source="Nicolas_upshifts" /id="D1983" /incds=0 /nref=13 /ntot=88 /MaxReadThrough="2.20109" /MaxDrop="4.23919" /score="27.0474383" /energy="-8" /TU="NA" /idTUdmin="U3015" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 3585413..3585420 /Source="Nicolas_upshift_promotors" /id="U3016" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.91008991008991" /psig="0.999000999001" /xcortree=3230 /SigmaFactorBS="aaactgtcctctcgagggcagttttttttatgtgcttcccct TATTGAAAagctggcgaattcCAATATAATGTATTTGTGGAtaccaaaggaggcaccc t" /listShort="ywbF, ywbE" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3585431 /Source="Nicolas_upshifts" /id="U3016" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.91008991008991" /psig="0.999000999001" /xcortree=3230 /SigmaFactorBS="aaactgtcctctcgagggcagttttttttatgtgcttcccct TATTGAAAagctggcgaattcCAATATAATGTATTTGTGGAtaccaaaggaggcaccc t" /listShort="ywbF, ywbE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3585434..3585453 /Source="Nicolas_upshift_promotors" /id="U3016" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.91008991008991" /psig="0.999000999001" /xcortree=3230 /SigmaFactorBS="aaactgtcctctcgagggcagttttttttatgtgcttcccct TATTGAAAagctggcgaattcCAATATAATGTATTTGTGGAtaccaaaggaggcaccc t" /listShort="ywbF, ywbE" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3585473..3586672 /gene="ywbF" /locus_tag="BSU_38340" /old_locus_tag="BSU38340" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative sugar permease" /protein_id="NP_391713.1" /db_xref="EnsemblGenomes-Gn:BSU38340" /db_xref="EnsemblGenomes-Tr:CAB15860" /db_xref="GOA:P39589" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR024989" /db_xref="InterPro:IPR026032" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10567" /db_xref="UniProtKB/Swiss-Prot:P39589" /translation="MHNLQVRRHYAALKGFYLFAFLGTGSIIPLLSMYLTKEQHLSGS QVGLIMSLGPIVMIFFQPFWGMLSDYTQKTKGLLAVCTSITGIIGLAYIAFDSFPLFI LIAACFAAFQSTIIPLSDSISLRYTQETNGNYGGIRLFGSLGFGVAVFAMGQVTNQLY PIHVIFIFGCAFLCIAAILASQVPGQQKTTKVNIRKGFRELISNKTFLIFMIITFTTF APNLANNTYFSLFLDKSGASLSAIGILFFIGVISEIPFMRFAQTFIDKMGLLNVIMLS GGVSLFRWALYFTAPSLWIIYATVFLQGVAIGLFIPAALQYVKKITPRHVEATALTMY AAIGNGFGNWFCTFAGGYIFDYVSIFAVYLLFGILSIAGFGLTLYLMKAEKNKHTLHQ PAVTFKP*" /label="ywbF CDS" gene 3585473..3586672 /gene="ywbF" /locus_tag="BSU_38340" /old_locus_tag="BSU38340" /label="ywbF gene" CDS 3586706..3586903 /gene="ywbE" /locus_tag="BSU_38350" /old_locus_tag="BSU38350" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391714.1" /db_xref="EnsemblGenomes-Gn:BSU38350" /db_xref="EnsemblGenomes-Tr:CAB15861" /db_xref="InterPro:IPR019240" /db_xref="SubtiList:BG10566" /db_xref="UniProtKB/Swiss-Prot:P39588" /translation="MNGQERNSISKGLQVDIVLKADQKTGKLTRGTVKDILTKSNFHP HGIKVRLEDGRIGRDQQIVST*" /label="ywbE CDS" gene 3586706..3586903 /gene="ywbE" /locus_tag="BSU_38350" /old_locus_tag="BSU38350" /label="ywbE gene" downshifts 3586882 /Source="Nicolas_upshifts" /id="D1984" /incds=0 /nref=15 /ntot=205 /MaxReadThrough="1.90583" /MaxDrop="4.20528" /score="21.8132292" /energy="-12.2" /TU="NA" /idTUdmin="U3016" /TUdmin=88 /isTUend="FALSE" /label="downshifts" CDS complement(3586938..3588128) /gene="rlmI" /locus_tag="BSU_38360" /old_locus_tag="BSU38360" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 18786544, 18789337; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="large subunit ribosomal RNA m5C1962 methyltransferase" /protein_id="NP_391715.1" /db_xref="EnsemblGenomes-Gn:BSU38360" /db_xref="EnsemblGenomes-Tr:CAB15862" /db_xref="GOA:P39587" /db_xref="InterPro:IPR002478" /db_xref="InterPro:IPR015947" /db_xref="InterPro:IPR019614" /db_xref="InterPro:IPR029063" /db_xref="InterPro:IPR036974" /db_xref="SubtiList:BG10565" /db_xref="UniProtKB/Swiss-Prot:P39587" /translation="MKLLTLKKAHAAKIKKGYPLIEKEALAGSAGHMKEGDLVDIVSE SGGEFLARGYYGLQNKGVGWTLTRNKHEQIDQAFFLSKLTKAAQARAKLFEAQDTTAF RLFNGEGDGVGGVTIDYYDGYLLIQWYSKGIYTFKDMLISALDEMDLDYKAIYEKKRF DTAGQYVEDDDFVKGRRGEFPIIIQENGIQYAVDLNEGAMTGIFLDQRHVRKAIRDRY AKGKTVLNTFSYTGAFSVAAALGGAEKTTSVDVANRSLAKTIEQFSVNKLDYEAHDIK VMDVFNYFSYAAKKDLRFDLIILDPPSFARTKKRTFSAAKDYKNLLKETIAITADKGV IVASTNSSAFGMKKFKGFIDAAFKETNERYTIIEEFTLPEDFKTISAFPEGNYLKVVL LQKK*" /label="rlmI CDS" gene complement(3586938..3588128) /gene="rlmI" /locus_tag="BSU_38360" /old_locus_tag="BSU38360" /label="rlmI gene" downshifts complement(3586953) /Source="Nicolas_upshifts" /id="D1985" /incds=0 /nref=5 /ntot=127 /MaxReadThrough="0.0525399999999996" /MaxDrop="4.51664" /score="48.4884619" /energy="-14.3" /TU="NA" /idTUdmin="U3017" /TUdmin=71 /isTUend="FALSE" /label="downshifts" downshifts complement(3587037) /Source="Nicolas_upshifts" /id="D1986" /incds=1 /nref=42 /ntot=233 /MaxReadThrough="2.99734" /MaxDrop="3.89369" /score="48.4884619" /energy="-14.3" /TU="NA" /idTUdmin="U3017" /TUdmin="-13" /isTUend="TRUE" /label="downshifts" misc_feature complement(3588152..3588171) /Source="Nicolas_upshift_promotors" /id="U3017" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.738261738261738" /psig=1 /xcortree=1883 /SigmaFactorBS="tttttgtctatcgtagaaaaacctttcctttctgtcaatgca gacatcttggcgtttTGTGGTACCATAAGAGAAAGcaaacggaaagaggacgacatat a" /listShort="ywbD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3588168) /Source="Nicolas_upshifts" /id="U3017" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.738261738261738" /psig=1 /xcortree=1883 /SigmaFactorBS="tttttgtctatcgtagaaaaacctttcctttctgtcaatgca gacatcttggcgtttTGTGGTACCATAAGAGAAAGcaaacggaaagaggacgacatat a" /listShort="ywbD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3588188..3588195 /Source="Nicolas_upshift_promotors" /id="U3018" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.517482517482518" /psig=1 /xcortree=1984 /SigmaFactorBS="tccgtttgctttctcttatggtaccacaaaacgccaagatgt ctGCATTGACagaaaggaaaggtTTTTCTACGATAGACAAAAAgagttacgaggagga g" /listShort="ywbC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3588204 /Source="Nicolas_upshifts" /id="U3018" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.517482517482518" /psig=1 /xcortree=1984 /SigmaFactorBS="tccgtttgctttctcttatggtaccacaaaacgccaagatgt ctGCATTGACagaaaggaaaggtTTTTCTACGATAGACAAAAAgagttacgaggagga g" /listShort="ywbC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3588209..3588228 /Source="Nicolas_upshift_promotors" /id="U3018" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.517482517482518" /psig=1 /xcortree=1984 /SigmaFactorBS="tccgtttgctttctcttatggtaccacaaaacgccaagatgt ctGCATTGACagaaaggaaaggtTTTTCTACGATAGACAAAAAgagttacgaggagga g" /listShort="ywbC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3588249..3588629 /gene="glxA" /locus_tag="BSU_38370" /old_locus_tag="BSU38370" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:24330391, 25283443" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 24330391, 25283443; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="glyoxalase I; hemithioacetal-bacillithiol lactoyl-bacillithiol formation" /protein_id="NP_391716.1" /db_xref="EnsemblGenomes-Gn:BSU38370" /db_xref="EnsemblGenomes-Tr:CAB15863" /db_xref="GOA:P39586" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR018146" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG10564" /db_xref="UniProtKB/Swiss-Prot:P39586" /translation="MAKRIDHTGIMVRDINASITFYEEVLGMKLKDRITHTNGVIELA FLGFEDGPETEIELIQGYSSELPAEGKVHHIALLTDDIAAEYTKAEKMNAKFIDEEIT TLPNGYRYFYIEGPDGEWIEFFQR*" /label="glxA CDS" gene 3588249..3588629 /gene="glxA" /locus_tag="BSU_38370" /old_locus_tag="BSU38370" /label="glxA gene" downshifts 3588527 /Source="Nicolas_upshifts" /id="D1987" /incds=1 /nref=14 /ntot=215 /MaxReadThrough="3.76076" /MaxDrop="3.68951" /score="-8.22053631" /energy="-7.4" /TU="U3018" /idTUdmin="U3018" /TUdmin="-357" /isTUend="FALSE" /label="downshifts" downshifts 3588598 /Source="Nicolas_upshifts" /id="D1988" /incds=0 /nref=1 /ntot=66 /MaxReadThrough="3.05249" /MaxDrop="3.56101" /score="-8.22053631" /energy="-7.4" /TU="U3018" /idTUdmin="U3018" /TUdmin="-286" /isTUend="FALSE" /label="downshifts" CDS complement(3588667..3589344) /gene="ywbB" /locus_tag="BSU_38380" /old_locus_tag="BSU38380" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391717.1" /db_xref="EnsemblGenomes-Gn:BSU38380" /db_xref="EnsemblGenomes-Tr:CAB15864" /db_xref="InterPro:IPR024250" /db_xref="SubtiList:BG10563" /db_xref="UniProtKB/Swiss-Prot:P39585" /translation="MLDYIWLDDESPILQQVPVEYSSAALIFSPFIQMPEGWENAKRK NDYEHIYPNDNEIRGIGKAVSWKKVMSSCGFQTHAELALALMTSIGALRDEFAREDLA EVLHENINGDLYYPSEDHISNFHIPSLVKVLGANGSNRFYYAEPIVENRGVLDITEAN LRTVLDEAATELVLTDEKMDFVFMSVYDSFINVFLAKDKNIHELVERMGWEAMICDES TYISWYR*" /label="ywbB CDS" gene complement(3588667..3589344) /gene="ywbB" /locus_tag="BSU_38380" /old_locus_tag="BSU38380" /label="ywbB gene" downshifts complement(3588674) /Source="Nicolas_upshifts" /id="D1989" /incds=0 /nref=6 /ntot=156 /MaxReadThrough="0.15283" /MaxDrop="5.41362" /score="0.491291944" /energy="-11.7" /TU="NA" /idTUdmin="U3020" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3589353..3589372) /Source="Nicolas_upshift_promotors" /id="U3019" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99100899100899" /psig="0.997002997002997" /xcortree=2178 /SigmaFactorBS="gataaaaatgtgatgtgatagatgatcagcctgtcatagggc tgatcaTCTCTTTcaaacgaaaggAATGTTAGAATATGTAAAGGaggtgcgcatgcta g" /listShort="ywbB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3589378) /Source="Nicolas_upshifts" /id="U3019" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99100899100899" /psig="0.997002997002997" /xcortree=2178 /SigmaFactorBS="gataaaaatgtgatgtgatagatgatcagcctgtcatagggc tgatcaTCTCTTTcaaacgaaaggAATGTTAGAATATGTAAAGGaggtgcgcatgcta g" /listShort="ywbB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3589384..3589390) /Source="Nicolas_upshift_promotors" /id="U3019" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.99100899100899" /psig="0.997002997002997" /xcortree=2178 /SigmaFactorBS="gataaaaatgtgatgtgatagatgatcagcctgtcatagggc tgatcaTCTCTTTcaaacgaaaggAATGTTAGAATATGTAAAGGaggtgcgcatgcta g" /listShort="ywbB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3589421..3590755) /gene="ywbA" /locus_tag="BSU_38390" /old_locus_tag="BSU38390" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8990303, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative cellobiose phosphotransferase system enzyme IIC permease component" /protein_id="NP_391718.1" /db_xref="EnsemblGenomes-Gn:BSU38390" /db_xref="EnsemblGenomes-Tr:CAB15865" /db_xref="GOA:P39584" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR004501" /db_xref="InterPro:IPR004796" /db_xref="SubtiList:BG10562" /db_xref="UniProtKB/Swiss-Prot:P39584" /translation="MSTFTRVMEEKIMPVAGKIAGQRHLSALRDGIILTMPLIIIGSV FLILTSLPIPGYADFMASVFGNEWADKLGYPVNASFDIMAMIAAFGIAYRLAESYGVD ALSAGAISIAAFLLATPFEVPFTPHGSTESIMVGGGIPITLLGSKGLFVAMLIALFST EIYRYIIQKNIVFKMPDGVPPAVSKSFVALIPGFIIVLLVWLARLLIEMTPFQSLHNV VGDLLGTPLSILGGSLGGSLIAEFVQMLLWSCGIHGASIIGGIMAPIWYGAMDANRLA FQAGEALPSIFTTQFFQIWINVGGSGATLALVLTMLVRSRSKQMKQLGRLGIGPALFN INEPIIFGMPIVMNPLLIVPFIIAPLLTITATYIGMSTGLVARPAGIAVPWTMPPLIS GYLATGGKVSGAVMQLVNLLITCAIYYPFFRIWDHQKWREESAVESGDKNVM*" /label="ywbA CDS" gene complement(3589421..3590755) /gene="ywbA" /locus_tag="BSU_38390" /old_locus_tag="BSU38390" /label="ywbA gene" misc_feature complement(3590803..3590821) /Source="Nicolas_upshift_promotors" /id="U3020" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.596403596403596" /psig="0.596403596403596" /xcortree=1254 /SigmaFactorBS="tttagcaaaatgcagattttttccgcatgaagaggaaatttt ccaaatgaatttgtaagcgttttCAAAATAAGATAAAGAAAAcattgcggaggttgtt c" /listShort="ywbA, ywbB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3590826) /Source="Nicolas_upshifts" /id="U3020" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.596403596403596" /psig="0.596403596403596" /xcortree=1254 /SigmaFactorBS="tttagcaaaatgcagattttttccgcatgaagaggaaatttt ccaaatgaatttgtaagcgttttCAAAATAAGATAAAGAAAAcattgcggaggttgtt c" /listShort="ywbA, ywbB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3590920..3590927 /Source="Nicolas_upshift_promotors" /id="U3021" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=2809 /SigmaFactorBS="ctgcattttgctaaacaaccctgcccatgaaaaattttttcc ttcttaCTATTAATctctctttttttcTCCGATATATATATCAAACatcatagaaaaa g" /listShort="epr" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3590932 /Source="Nicolas_upshifts" /id="U3021" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=2809 /SigmaFactorBS="ctgcattttgctaaacaaccctgcccatgaaaaattttttcc ttcttaCTATTAATctctctttttttcTCCGATATATATATCAAACatcatagaaaaa g" /listShort="epr" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3590941..3590959 /Source="Nicolas_upshift_promotors" /id="U3021" /multdbtbs="SigD" /comp="M10" /sig="SigD" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=2809 /SigmaFactorBS="ctgcattttgctaaacaaccctgcccatgaaaaattttttcc ttcttaCTATTAATctctctttttttcTCCGATATATATATCAAACatcatagaaaaa g" /listShort="epr" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3590983..3592920 /gene="epr" /locus_tag="BSU_38400" /old_locus_tag="BSU38400" /EC_number="3.4.21.-" /function="16.11: Scavenge (Catabolism)" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:1938892, 2116590, 16553828, 17666034, 19416356, 23660663, 25966269" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1938892, 2116590, 16553828, 17666034, 19416356, 23660663, 25966269; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="extracellular serine protease" /protein_id="NP_391719.1" /db_xref="EnsemblGenomes-Gn:BSU38400" /db_xref="EnsemblGenomes-Tr:CAB15866" /db_xref="GOA:P16396" /db_xref="InterPro:IPR000209" /db_xref="InterPro:IPR009020" /db_xref="InterPro:IPR015500" /db_xref="InterPro:IPR022398" /db_xref="InterPro:IPR023827" /db_xref="InterPro:IPR023828" /db_xref="InterPro:IPR034202" /db_xref="InterPro:IPR036852" /db_xref="InterPro:IPR037045" /db_xref="SubtiList:BG10561" /db_xref="UniProtKB/Swiss-Prot:P16396" /translation="MKNMSCKLVVSVTLFFSFLTIGPLAHAQNSSEKEVIVVYKNKAG KETILDSDADVEQQYKHLPAVAVTADQETVKELKQDPDILYVENNVSFTAADSTDFKV LSDGTDTSDNFEQWNLEPIQVKQAWKAGLTGKNIKIAVIDSGISPHDDLSIAGGYSAV SYTSSYKDDNGHGTHVAGIIGAKHNGYGIDGIAPEAQIYAVKALDQNGSGDLQSLLQG IDWSIANRMDIVNMSLGTTSDSKILHDAVNKAYEQGVLLVAASGNDGNGKPVNYPAAY SSVVAVSATNEKNQLASFSTTGDEVEFSAPGTNITSTYLNQYYATGSGTSQATPHAAA MFALLKQRDPAETNVQLREEMRKNIVDLGTAGRDQQFGYGLIQYKAQATDSAYAAAEQ AVKKAEQTKAQIDINKARELISQLPNSDAKTALHKRLDKVQSYRNVKDAKDKVAKAEK YKTQQTVDTAQTAINKLPNGTDKKNLQKRLDQVKRYIASKQAKDKVAKAEKSKKKTDV DSAQSAIGKLPASSEKTSLQKRLNKVKSTNLKTAQQSVSAAEKKSTDANAAKAQSAVN QLQAGKDKTALQKRLDKVKKKVAAAEAKKVETAKAKVKKAEKDKTKKSKTSAQSAVNQ LKASNEKTKLQKRLNAVKPKK*" /label="epr CDS" gene 3590983..3592920 /gene="epr" /locus_tag="BSU_38400" /old_locus_tag="BSU38400" /label="epr gene" promotor_-10 complement(3592127..3592146) /Source="Nicolas_upshift_promotors" /id="U3022" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.81018981018981" /psig="0.81018981018981" /xcortree=1236 /SigmaFactorBS="tgcttttgtttgttccgcttTTTTCACCGcttgctctgctgc CGCGTACGCTGAATCTGTTGcctgtgctttatactggattaagccgtagccaaattgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3592128) /Source="Nicolas_upshifts" /id="U3022" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.81018981018981" /psig="0.81018981018981" /xcortree=1236 /SigmaFactorBS="tgcttttgtttgttccgcttTTTTCACCGcttgctctgctgc CGCGTACGCTGAATCTGTTGcctgtgctttatactggattaagccgtagccaaattgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3592160..3592168) /Source="Nicolas_upshift_promotors" /id="U3022" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.81018981018981" /psig="0.81018981018981" /xcortree=1236 /SigmaFactorBS="tgcttttgtttgttccgcttTTTTCACCGcttgctctgctgc CGCGTACGCTGAATCTGTTGcctgtgctttatactggattaagccgtagccaaattgc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3592910 /Source="Nicolas_upshifts" /id="D1990" /incds=0 /nref=175 /ntot=224 /MaxReadThrough="1.26567" /MaxDrop="6.00181" /score="15.6173594" /energy="-13" /TU="NA" /idTUdmin="U3021" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 3593023..3593030 /Source="Nicolas_upshift_promotors" /id="U3023" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.813186813186813" /psig="0.99000999000999" /xcortree=1754 /SigmaFactorBS="ttgtacaggcttttcatacTATTGCTAtacagccatgaacaG CATAAAATGAACGTTATTAcagttatcaccacatatggcgggattgtgactgggcagg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3593045..3593064 /Source="Nicolas_upshift_promotors" /id="U3023" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.813186813186813" /psig="0.99000999000999" /xcortree=1754 /SigmaFactorBS="ttgtacaggcttttcatacTATTGCTAtacagccatgaacaG CATAAAATGAACGTTATTAcagttatcaccacatatggcgggattgtgactgggcagg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3593064 /Source="Nicolas_upshifts" /id="U3023" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.813186813186813" /psig="0.99000999000999" /xcortree=1754 /SigmaFactorBS="ttgtacaggcttttcatacTATTGCTAtacagccatgaacaG CATAAAATGAACGTTATTAcagttatcaccacatatggcgggattgtgactgggcagg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3593276..3593283 /Source="Nicolas_upshift_promotors" /id="U3024" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.447552447552448" /psig="0.996003996003996" /xcortree=2192 /SigmaFactorBS="catttttgtcattttcagccggtatttctcacttttttcaTT TTGATTgtcaacttttcaTTTGATACGATGAACAAGCCgacttttcttcagcaaagga g" /listShort="sacX, sacY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3593296..3593315 /Source="Nicolas_upshift_promotors" /id="U3024" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.447552447552448" /psig="0.996003996003996" /xcortree=2192 /SigmaFactorBS="catttttgtcattttcagccggtatttctcacttttttcaTT TTGATTgtcaacttttcaTTTGATACGATGAACAAGCCgacttttcttcagcaaagga g" /listShort="sacX, sacY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3593296 /Source="Nicolas_upshifts" /id="U3024" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.447552447552448" /psig="0.996003996003996" /xcortree=2192 /SigmaFactorBS="catttttgtcattttcagccggtatttctcacttttttcaTT TTGATTgtcaacttttcaTTTGATACGATGAACAAGCCgacttttcttcagcaaagga g" /listShort="sacX, sacY" /GFF_Attribute="listLong" /label="upshifts" CDS 3593348..3594727 /gene="sacX" /locus_tag="BSU_38410" /old_locus_tag="BSU38410" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11580842, 1400159, 8535520, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11580842, 1400159, 8535520, 15849754, 16850406; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative regulator of SacY" /protein_id="NP_391720.1" /db_xref="EnsemblGenomes-Gn:BSU38410" /db_xref="EnsemblGenomes-Tr:CAB15867" /db_xref="GOA:P15400" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR010973" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="SubtiList:BG10560" /db_xref="UniProtKB/Swiss-Prot:P15400" /translation="MHKEIAKELLLLAGGKNNIISISHCTTRLRFDVKDETKIDIHAI ENLQGVQGTFFRYGLFQIIFGAGVVNKIYKEVVHVWETAPSEEPVHQKKASRKLNPAA AFAKTLSDIFVPIIPAITASGLLMGLIGMIKVFHWFAAGSPWIKMLDLVSSTAFILLP ILVGFSAARQFGSNPYLGAVIAGLLTHPDLLDPSMLGSKTPSSLDIWGLHIPMMGYQG SMIPILLSVFVMSKIEKLLKSIVPKSLDVVIIPFITVMVTGCLALIVMNPAASIIGQI MTQSIVYIYDHAGIAAGALFGGIYSTIVLSGLHHSFYAIEATLLANPHVGVNFLVPIW SMANVAQGGAGLAVFLKTKQSSLKKIALPASLTAFLGIVEPIVFGVNLKLIRPFIGAA IGGAIGGAYVVAVQVVANSYGLTGIPMISIVLPFGAANFVHYMIGFLIAAVSAFIATL FLGFKEETE*" /label="sacX CDS" gene 3593348..3594727 /gene="sacX" /locus_tag="BSU_38410" /old_locus_tag="BSU38410" /label="sacX gene" S_feature complement(3594436..3595639) /Source="Nicolas_S_feature" /locus_tag="new_3943322_3944525_c" /HighExp="Etha, B36, B60, M9-stat, Salt, Sw, LoTm, C30, Gly, Heat" /AntisenseName="sacY" /AntisenseCor="-0.177403958488455" /AntisenseRegPval="-2.5" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1477" CDS 3594781..3595623 /gene="sacY" /locus_tag="BSU_38420" /old_locus_tag="BSU38420" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9305644, 9457872, 11580842, 12079345, 15528654, 21278164" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9305644, 9457872, 11580842, 12079345, 15528654, 21278164; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional antiterminator" /protein_id="NP_391721.1" /db_xref="EnsemblGenomes-Gn:BSU38420" /db_xref="EnsemblGenomes-Tr:CAB15868" /db_xref="GOA:P15401" /db_xref="InterPro:IPR001550" /db_xref="InterPro:IPR004341" /db_xref="InterPro:IPR011608" /db_xref="InterPro:IPR036634" /db_xref="InterPro:IPR036650" /db_xref="PDB:1AUU" /db_xref="SubtiList:BG10559" /db_xref="UniProtKB/Swiss-Prot:P15401" /translation="MKIKRILNHNAIVVKDQNEEKILLGAGIAFNKKKNDIVDPSKIE KTFIRKDTPDYKQFEEILETLPEDHIQISEQIISHAEKELNIKINERIHVAFSDHLSF AIERLSNGMVIKNPLLNEIKVLYPKEFQIGLWARALIKDKLGIHIPDDEIGNIAMHIH TARNNAGDMTQTLDITTMIRDIIEIIEIQLSINIVEDTISYERLVTHLRFAIQHIKAG ESIYELDAEMIDIIKEKFKDAFLCALSIGTFVKKEYGFEFPEKELCYIAMHIQRFYQR SVAR*" /label="sacY CDS" gene 3594781..3595623 /gene="sacY" /locus_tag="BSU_38420" /old_locus_tag="BSU38420" /label="sacY gene" CDS complement(3595674..3596534) /gene="gspA" /locus_tag="BSU_38430" /old_locus_tag="BSU38430" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11377871, 19659723; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyl transferase (general stress protein)" /protein_id="NP_391722.1" /db_xref="EnsemblGenomes-Gn:BSU38430" /db_xref="EnsemblGenomes-Tr:CAB15869" /db_xref="GOA:P25148" /db_xref="InterPro:IPR002495" /db_xref="InterPro:IPR029044" /db_xref="SubtiList:BG10558" /db_xref="UniProtKB/Swiss-Prot:P25148" /translation="MRKDEIMHIVSCADDNYARHLGGMFVSLLTNMDQEREVKLYVID GGIKPDNKKRLEETTLKFGVPIEFLEVDTNMYEHAVESSHITKAAYYRISIPDLIKDE SIKRMIYIDCDALVLEDISKLWDLDIAPYTVAAVEDAGQHERLKEMNVTDTGKYFNSG IMIIDFESWRKQNITEKVINFINEHPDEDFLVLHDQDALNAILYDQWYELHPRWNAQT YIMLKLKTPSTLLGRKQYNETRENPAIVHFCGGEKPWNSNTKHPYRDEYFHYMSYTKW NTIGNPAINQ*" /label="gspA CDS" gene complement(3595674..3596534) /gene="gspA" /locus_tag="BSU_38430" /old_locus_tag="BSU38430" /label="gspA gene" downshifts complement(3595684) /Source="Nicolas_upshifts" /id="D1991" /incds=0 /nref=73 /ntot=227 /MaxReadThrough="5.61926" /MaxDrop="7.47527" /score="21.8603429" /energy="-10.6" /TU="U3025" /idTUdmin="U3025" /TUdmin="-1224" /isTUend="FALSE" /label="downshifts" downshifts 3596518 /Source="Nicolas_upshifts" /id="D1992" /incds=0 /nref=8 /ntot=30 /MaxReadThrough="1.49599" /MaxDrop="5.33818" /score="10.6843241" /energy="-4.5" /TU="NA" /idTUdmin="U3026" /TUdmin="-528" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3596556..3596574) /Source="Nicolas_upshift_promotors" /id="U3025" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=226 /SigmaFactorBS="tgttgtatcacacattctgtttaaaaaaatgtcggagaaCGT GTTTatttttttgaaaaaGGGTATGTAACTTGTACAAcaaaaagggagatgaatacca t" /listShort="gspA, S1477" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3596574) /Source="Nicolas_upshifts" /id="U3025" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=226 /SigmaFactorBS="tgttgtatcacacattctgtttaaaaaaatgtcggagaaCGT GTTTatttttttgaaaaaGGGTATGTAACTTGTACAAcaaaaagggagatgaatacca t" /listShort="gspA, S1477" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3596589..3596595) /Source="Nicolas_upshift_promotors" /id="U3025" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=226 /SigmaFactorBS="tgttgtatcacacattctgtttaaaaaaatgtcggagaaCGT GTTTatttttttgaaaaaGGGTATGTAACTTGTACAAcaaaaagggagatgaatacca t" /listShort="gspA, S1477" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3596644..3597357) /gene="ywaF" /locus_tag="BSU_38440" /old_locus_tag="BSU38440" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein of unknown function" /protein_id="NP_391723.1" /db_xref="EnsemblGenomes-Gn:BSU38440" /db_xref="EnsemblGenomes-Tr:CAB15870" /db_xref="GOA:P25149" /db_xref="InterPro:IPR011737" /db_xref="SubtiList:BG10557" /db_xref="UniProtKB/Swiss-Prot:P25149" /translation="MQKYVQSDYKHDPFHLFSTEHVVTLAIISLLAILLFLFQDEVKQ PRASRFLRSLFVFLLLGSQIGYQIWMVATDRWSVRTSLPLQLSDLSVYLSAIMLVTKS RKLFVFLFFVGIGSSIQALATPDLGMFSFPHIRYILFFISHGSVFLSCLLMAVIGTYR MGQRSLWVTVLLVNVYGVCIFLIDRWLGANYMYLTKKPGGSSLLDVLGPWPWYIVSAE AITIASFFILYWLYRIFKK*" /label="ywaF CDS" gene complement(3596644..3597357) /gene="ywaF" /locus_tag="BSU_38440" /old_locus_tag="BSU38440" /label="ywaF gene" promotor_-35 3596759..3596760 /Source="Nicolas_upshift_promotors" /id="U3026" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.275724275724276" /psig="0.275724275724276" /xcortree=93 /SigmaFactorBS="ccacggccatggcccgagaacatctaagagagaggaaCCgcc cggttttttcgtcaaaTACATATAATTCGCGCCAagccagcgatcaatcagaaaaata c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3596780..3596797 /Source="Nicolas_upshift_promotors" /id="U3026" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.275724275724276" /psig="0.275724275724276" /xcortree=93 /SigmaFactorBS="ccacggccatggcccgagaacatctaagagagaggaaCCgcc cggttttttcgtcaaaTACATATAATTCGCGCCAagccagcgatcaatcagaaaaata c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3596782 /Source="Nicolas_upshifts" /id="U3026" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.275724275724276" /psig="0.275724275724276" /xcortree=93 /SigmaFactorBS="ccacggccatggcccgagaacatctaagagagaggaaCCgcc cggttttttcgtcaaaTACATATAATTCGCGCCAagccagcgatcaatcagaaaaata c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3597385..3597396) /Source="Nicolas_upshift_promotors" /id="U3027" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=818 /SigmaFactorBS="ggtgtgaacttcaagcccatatatcggttGAATAAAaaaagc ccaaacaaCGCCAAAATAAAcaaaaacccgaaaacgggggtgcagttttgcaaaaata t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3597386) /Source="Nicolas_upshifts" /id="U3027" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=818 /SigmaFactorBS="ggtgtgaacttcaagcccatatatcggttGAATAAAaaaagc ccaaacaaCGCCAAAATAAAcaaaaacccgaaaacgggggtgcagttttgcaaaaata t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3597411..3597417) /Source="Nicolas_upshift_promotors" /id="U3027" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.995004995004995" /psig="0.995004995004995" /xcortree=818 /SigmaFactorBS="ggtgtgaacttcaagcccatatatcggttGAATAAAaaaagc ccaaacaaCGCCAAAATAAAcaaaaacccgaaaacgggggtgcagttttgcaaaaata t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3597432..3597438 /Source="Nicolas_upshift_promotors" /id="U3028" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.462537462537463" /psig="0.842157842157842" /xcortree=659 /SigmaFactorBS="gggctttttttattcaaccgatatatgggCTTGAAGttcaca ccagactcTGTTAAAATTCGTTTCATAGctaatgattctgataatttaaggcaggcct a" /listShort="ywaE, NA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3597453..3597472 /Source="Nicolas_upshift_promotors" /id="U3028" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.462537462537463" /psig="0.842157842157842" /xcortree=659 /SigmaFactorBS="gggctttttttattcaaccgatatatgggCTTGAAGttcaca ccagactcTGTTAAAATTCGTTTCATAGctaatgattctgataatttaaggcaggcct a" /listShort="ywaE, NA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3597463 /Source="Nicolas_upshifts" /id="U3028" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.462537462537463" /psig="0.842157842157842" /xcortree=659 /SigmaFactorBS="gggctttttttattcaaccgatatatgggCTTGAAGttcaca ccagactcTGTTAAAATTCGTTTCATAGctaatgattctgataatttaaggcaggcct a" /listShort="ywaE, NA" /GFF_Attribute="listLong" /label="upshifts" CDS 3597508..3598023 /gene="tyrZR" /locus_tag="BSU_38450" /old_locus_tag="BSU38450" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:25733610" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25733610; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator controlling expressionof tyrZ" /protein_id="NP_391724.1" /db_xref="EnsemblGenomes-Gn:BSU38450" /db_xref="EnsemblGenomes-Tr:CAB15871" /db_xref="GOA:P25150" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10556" /db_xref="UniProtKB/Swiss-Prot:P25150" /translation="MERSHQHQQLRKEEHDTLSKLKQMPVESLNLEAISIATNLYRSA QRLRVKMETEVLSTYNLSWTAFSILYDLWVWGALETRKIAELSGISTATASNVIKTLE KKSFCRKSIDTRDRRLVFVSITDSGKQAIEELYPEFHKGETELIAGMTKDEQKILTGL LRKVADNLHTT*" /label="tyrZR CDS" gene 3597508..3598023 /gene="tyrZR" /locus_tag="BSU_38450" /old_locus_tag="BSU38450" /label="tyrZR gene" misc_RNA 3598024..3598230 /gene="tboYB" /locus_tag="BSU_misc_RNA_59" /product="T-box riboswitch specific of tyrosine tRNA ligase" /experiment="publication(s) with functional evidences, PMID:8045882, 9098041, 10943892, 11842119, 12165569, 12547201, 1317842" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8045882, 9098041, 10943892, 11842119, 12165569, 12547201, 1317842; Product type n: RNA" /function="16.3: Control" /label="tboYB RNA" gene 3598024..3598230 /gene="tboYB" /locus_tag="BSU_misc_RNA_59" /label="tboYB gene" downshifts 3598190 /Source="Nicolas_upshifts" /id="D1993" /incds=0 /nref=15 /ntot=112 /MaxReadThrough="1.84575" /MaxDrop="4.56656" /score="23.8000948" /energy="-14.5" /TU="NA" /idTUdmin="U3028" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 3598272..3599513 /gene="tyrZ" /locus_tag="BSU_38460" /old_locus_tag="BSU38460" /EC_number="6.1.1.1" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1735721, 1806041, 25733610" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1735721, 1806041, 25733610; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tyrosyl-tRNA synthetase" /protein_id="NP_391725.1" /db_xref="EnsemblGenomes-Gn:BSU38460" /db_xref="EnsemblGenomes-Tr:CAB15872" /db_xref="GOA:P25151" /db_xref="InterPro:IPR001412" /db_xref="InterPro:IPR002305" /db_xref="InterPro:IPR002307" /db_xref="InterPro:IPR002942" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR024088" /db_xref="InterPro:IPR024108" /db_xref="InterPro:IPR036986" /db_xref="SubtiList:BG10555" /db_xref="UniProtKB/Swiss-Prot:P25151" /translation="MMRTFEQLTASQQKEVERQLQLYMTGAHEVIPPEELKAKLVKSI STGTPLKIKLGLDPSAPDVHLGHTVVLNKLRQFQENGHIVQLLIGDFTGKIGDPTGKS AARKQLTDEEVQHNAKTYFEQFGKVLDPEKVELHYNSKWLKTLNLEDVIELAGKITVA RLMERDDFEERIAMQKPISLHEFFYPLMQGYDSVVLESDIELGGTDQHFNVLMGRHFQ ERYNKEKQVVILMPLLEGLDGVEKMSKSKHNYIGINEHPNDMYGKTMSLPDSLMKKYI HLATDLELEEKKQLVKDLETGAVHPRDAKMLLARTIVRMYHGEKAAEAAEHSFKTVFQ ENSLPEDIPAVNWKGEKTIAMIDLLVKLKLLSSKSEARRMIQNGGVRIDGEKVTDVHA KAEIRENMIIQVGKRKFLKLQ*" /label="tyrZ CDS" gene 3598272..3599513 /gene="tyrZ" /locus_tag="BSU_38460" /old_locus_tag="BSU38460" /label="tyrZ gene" promotor_-35 3599604..3599612 /Source="Nicolas_upshift_promotors" /id="U3029" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=502 /SigmaFactorBS="cactgtcttttcaaaaacgctctccatcttGCAGGAAACtcc tttagcaTCCCGAAATATTCCCCAACcatacatttaggggaggtttatttttgatgaa a" /listShort="ywaD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3599623..3599641 /Source="Nicolas_upshift_promotors" /id="U3029" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=502 /SigmaFactorBS="cactgtcttttcaaaaacgctctccatcttGCAGGAAACtcc tttagcaTCCCGAAATATTCCCCAACcatacatttaggggaggtttatttttgatgaa a" /listShort="ywaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3599634 /Source="Nicolas_upshifts" /id="U3029" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=502 /SigmaFactorBS="cactgtcttttcaaaaacgctctccatcttGCAGGAAACtcc tttagcaTCCCGAAATATTCCCCAACcatacatttaggggaggtttatttttgatgaa a" /listShort="ywaD" /GFF_Attribute="listLong" /label="upshifts" CDS 3599669..3601036 /gene="eapD" /locus_tag="BSU_38470" /old_locus_tag="BSU38470" /EC_number="3.4.11.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15668014, 23426795, 26898926, 28257579" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15668014, 23426795, 26898926, 28257579; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="exported double-zinc aminopeptidase" /protein_id="NP_391726.1" /db_xref="EnsemblGenomes-Gn:BSU38470" /db_xref="EnsemblGenomes-Tr:CAB15873" /db_xref="GOA:P25152" /db_xref="InterPro:IPR003137" /db_xref="InterPro:IPR007484" /db_xref="SubtiList:BG10554" /db_xref="UniProtKB/Swiss-Prot:P25152" /translation="MKKLLTVMTMAVLTAGTLLLPAQSVTPAAHAVQISNSERELPFK AKHAYSTISQLSEAIGPRIAGTAAEKKSALLIASSMRKLKLDVKVQRFNIPDRLEGTL SSAGRDILLQAASGSAPTEEQGLTAPLYNAGLGYQKDFTADAKGKIALISRGDLTYYE KAKNAEAAGAKAVIIYNNKESLVPMTPNLSGNKVGIPVVGIKKEDGEALTQQKEATLK LKAFTNQTSQNIIGIKKPKNIKHPDIVYVTAHYDSVPFSPGANDNGSGTSVMLEMARV LKSVPSDKEIRFIAFGAEELGLLGSSHYVDHLSEKELKRSEVNFNLDMVGTSWEKASE LYVNTLDGQSNYVWESSRTAAEKIGFDSLSLTQGGSSDHVPFHEAGIDSANFIWGDPE TEEVEPWYHTPEDSIEHISKERLQQAGDLVTAAVYEAVKKEKKPKTIKKQMKAKASDI FEDIK*" /label="eapD CDS" gene 3599669..3601036 /gene="eapD" /locus_tag="BSU_38470" /old_locus_tag="BSU38470" /label="eapD gene" downshifts 3601013 /Source="Nicolas_upshifts" /id="D1994" /incds=0 /nref=3 /ntot=37 /MaxReadThrough="1.38814" /MaxDrop="6.05871" /score="27.7635079" /energy="-13.3" /TU="NA" /idTUdmin="U3029" /TUdmin=7 /isTUend="TRUE" /label="downshifts" CDS complement(3601066..3601698) /gene="relQ" /locus_tag="BSU_38480" /old_locus_tag="BSU38480" /EC_number="2.7.6.5" /function="16.7: Manage energy" /function="16.3: Control" /function="16.14: Store" /experiment="publication(s) with functional evidences, PMID:17714452, 18067544, 19447912, 22333191, 22950019, 24163341, 25331430, 26211718" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17714452, 18067544, 19447912, 22333191, 22950019, 24163341, 25331430, 26211718; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="(p)ppGpp synthetase" /protein_id="NP_391727.1" /db_xref="EnsemblGenomes-Gn:BSU38480" /db_xref="EnsemblGenomes-Tr:CAB15874" /db_xref="GOA:P39583" /db_xref="InterPro:IPR007685" /db_xref="SubtiList:BG10553" /db_xref="UniProtKB/Swiss-Prot:P39583" /translation="MDLSVTHMDDLKTVMEDWKNELLVYKFALDALDTKFSIISQEYN LIHGHNPIEHTKSRVKSFESIVNKLMRKGCEITTKEMKEHIHDIAGVRIICSFISDIY NVVNVLKQHEDLRIVKVKDYIQTPKPNGYRSLHLIIEMPVNLTNRVEYVKAEIQIRTI AMDFWASLEHKIYYKLNNDVPKQLTDELKEAAEIAHYLDEKMLGIKKEVD*" /label="relQ CDS" gene complement(3601066..3601698) /gene="relQ" /locus_tag="BSU_38480" /old_locus_tag="BSU38480" /label="relQ gene" downshifts complement(3601084) /Source="Nicolas_upshifts" /id="D1995" /incds=0 /nref=200 /ntot=257 /MaxReadThrough="2.49976" /MaxDrop="5.49802" /score="47.236042" /energy="-13.3" /TU="NA" /idTUdmin="U3030" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3601734..3601749) /Source="Nicolas_upshift_promotors" /id="U3030" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1644 /SigmaFactorBS="tacaatcgaccgcattttgtaaaaaaattcatAGAACCTTGc agcagacagggACGTCTAGTACATGGAcagcggataaagttccgttaaaggagatgac g" /listShort="ywaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3601742) /Source="Nicolas_upshifts" /id="U3030" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1644 /SigmaFactorBS="tacaatcgaccgcattttgtaaaaaaattcatAGAACCTTGc agcagacagggACGTCTAGTACATGGAcagcggataaagttccgttaaaggagatgac g" /listShort="ywaC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3601762..3601770) /Source="Nicolas_upshift_promotors" /id="U3030" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1644 /SigmaFactorBS="tacaatcgaccgcattttgtaaaaaaattcatAGAACCTTGc agcagacagggACGTCTAGTACATGGAcagcggataaagttccgttaaaggagatgac g" /listShort="ywaC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3601840..3602775) /gene="menA" /locus_tag="BSU_38490" /old_locus_tag="BSU38490" /EC_number="2.5.1.74" /function="16.2: Construct biomass (Anabolism)" /function="16.10: Respire" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 6780514, 9573170, 12682299, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="1,4-dihydroxy-2-naphthoate octaprenyltransferase" /protein_id="NP_391728.1" /db_xref="EnsemblGenomes-Gn:BSU38490" /db_xref="EnsemblGenomes-Tr:CAB15875" /db_xref="GOA:P39582" /db_xref="InterPro:IPR000537" /db_xref="InterPro:IPR004657" /db_xref="InterPro:IPR026046" /db_xref="SubtiList:BG10552" /db_xref="UniProtKB/Swiss-Prot:P39582" /translation="MNQTNKGEGQTAPQKESMGQILWQLTRPHTLTASFVPVLLGTVL AMFYVKVDLLLFLAMLFSCLWIQIATNLFNEYYDFKRGLDTAESVGIGGAIVRHGMKP KTILQLALASYGIAILLGVYICASSSWWLALIGLVGMAIGYLYTGGPLPIAYTPFGEL FSGICMGSVFVLISFFIQTDKINMQSILISIPIAILVGAINLSNNIRDIEEDKKGGRK TLAILMGHKGAVTLLAASFAVAYIWVVGLVITGAASPWLFVVFLSVPKPVQAVKGFVQ NEMPMNMIVAMKSTAQTNTFFGFLLSIGLLISYFR*" /label="menA CDS" gene complement(3601840..3602775) /gene="menA" /locus_tag="BSU_38490" /old_locus_tag="BSU38490" /label="menA gene" downshifts complement(3601852) /Source="Nicolas_upshifts" /id="D1996" /incds=0 /nref=10 /ntot=113 /MaxReadThrough="3.08081" /MaxDrop="4.6874" /score="16.8971767" /energy="-8.5" /TU="NA" /idTUdmin="U3032" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 3602519..3602528 /Source="Nicolas_upshift_promotors" /id="U3031" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=1379 /SigmaFactorBS="cgtacaatggcccctccgattccgactgattctGCTGTATCT AatccgcgtttaaaATCATAGTATTCATTAAATAagttcgtcgcgatctggatccata g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3602542..3602561 /Source="Nicolas_upshift_promotors" /id="U3031" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=1379 /SigmaFactorBS="cgtacaatggcccctccgattccgactgattctGCTGTATCT AatccgcgtttaaaATCATAGTATTCATTAAATAagttcgtcgcgatctggatccata g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3602546 /Source="Nicolas_upshifts" /id="U3031" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.97902097902098" /psig="0.97902097902098" /xcortree=1379 /SigmaFactorBS="cgtacaatggcccctccgattccgactgattctGCTGTATCT AatccgcgtttaaaATCATAGTATTCATTAAATAagttcgtcgcgatctggatccata g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3602776..3602863) /Source="Nicolas_S_feature" /locus_tag="new_3951662_3951749_c" /HighExp="LBGstat, Paraq, G180, LBGexp, G135, Oxctl, C30, Cold, Diami, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.81271400000000005" /TUshortSig="SigA, Sig-" /TUshortPSig="0.999, 0.498" /TUlongSig="NA" /TUlongPSig="NA" /label="S1478" promotor_-10 complement(3602846..3602865) /Source="Nicolas_upshift_promotors" /id="U3032" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.801198801198801" /psig="0.999000999001" /xcortree=2514 /SigmaFactorBS="gaagcgtataataagaaagaaaacgccttcttgcggtaTCTT GtgaaataagggagaaGTCATTATGATAGATAAGGAagcaaaaggagttttttattaa g" /listShort="S1478, menA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3602863) /Source="Nicolas_upshifts" /id="U3032" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.801198801198801" /psig="0.999000999001" /xcortree=2514 /SigmaFactorBS="gaagcgtataataagaaagaaaacgccttcttgcggtaTCTT GtgaaataagggagaaGTCATTATGATAGATAAGGAagcaaaaggagttttttattaa g" /listShort="S1478, menA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3602881..3602885) /Source="Nicolas_upshift_promotors" /id="U3032" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.801198801198801" /psig="0.999000999001" /xcortree=2514 /SigmaFactorBS="gaagcgtataataagaaagaaaacgccttcttgcggtaTCTT GtgaaataagggagaaGTCATTATGATAGATAAGGAagcaaaaggagttttttattaa g" /listShort="S1478, menA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3602908..3602920) /Source="Nicolas_upshift_promotors" /id="U3033" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.497502497502497" /psig="0.497502497502497" /xcortree=2049 /SigmaFactorBS="cctgttcgttcaagtgaaagcagaaacCTAATGAaatcaggg cgagaaGCGTATAATAAGAaagaaaacgccttcttgcggtatcttgtgaaataaggga g" /listShort="S1478, menA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3602908) /Source="Nicolas_upshifts" /id="U3033" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.497502497502497" /psig="0.497502497502497" /xcortree=2049 /SigmaFactorBS="cctgttcgttcaagtgaaagcagaaacCTAATGAaatcaggg cgagaaGCGTATAATAAGAaagaaaacgccttcttgcggtatcttgtgaaataaggga g" /listShort="S1478, menA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3602935..3602941) /Source="Nicolas_upshift_promotors" /id="U3033" /multdbtbs="-" /comp="M8" /sig="Sig-" /pcomp="0.497502497502497" /psig="0.497502497502497" /xcortree=2049 /SigmaFactorBS="cctgttcgttcaagtgaaagcagaaacCTAATGAaatcaggg cgagaaGCGTATAATAAGAaagaaaacgccttcttgcggtatcttgtgaaataaggga g" /listShort="S1478, menA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3602938..3603072) /locus_tag="BSU_38495" /old_locus_tag="BSU38495" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514012.1" /translation="MECFELIHNKGKDTWSQKIFLTFKKCNVLKKIFLYLFVQVKAET *" /label="hypothetical protein CDS" gene complement(3602938..3603072) /locus_tag="BSU_38495" /old_locus_tag="BSU38495" /label="gene" promotor_-35 3603019..3603026 /Source="Nicolas_upshift_promotors" /id="U3034" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.884115884115884" /psig="0.998001998001998" /xcortree=2465 /SigmaFactorBS="tacattacactttttaaaagttaaaaagatCTTTTGACtcca ggtatctttTCCTTTATTATGAATCAGCTcgaaacattccattcttgcccttgcaggt a" /listShort="S1479" /listLong="ywzH, dltA, dltB, dltC, dltD, S1480, dltE, ilvK" /label="promotor_-35" promotor_-10 3603040..3603059 /Source="Nicolas_upshift_promotors" /id="U3034" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.884115884115884" /psig="0.998001998001998" /xcortree=2465 /SigmaFactorBS="tacattacactttttaaaagttaaaaagatCTTTTGACtcca ggtatctttTCCTTTATTATGAATCAGCTcgaaacattccattcttgcccttgcaggt a" /listShort="S1479" /listLong="ywzH, dltA, dltB, dltC, dltD, S1480, dltE, ilvK" /label="promotor_-10" upshifts 3603049 /Source="Nicolas_upshifts" /id="U3034" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.884115884115884" /psig="0.998001998001998" /xcortree=2465 /SigmaFactorBS="tacattacactttttaaaagttaaaaagatCTTTTGACtcca ggtatctttTCCTTTATTATGAATCAGCTcgaaacattccattcttgcccttgcaggt a" /listShort="S1479" /listLong="ywzH, dltA, dltB, dltC, dltD, S1480, dltE, ilvK" /label="upshifts" S_feature 3603052..3603156 /Source="Nicolas_S_feature" /locus_tag="new_3951938_3952042" /HighExp="H2O2, Paraq, Oxctl, G180, G150, C30, G135, LBGstat, dia15, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1479" promotor_-35 3603151..3603160 /Source="Nicolas_upshift_promotors" /id="U3035" /multdbtbs="SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2508 /SigmaFactorBS="cattttcaaaaacatacgccgatatattaatttgagggagat tagggaaaaaaTGAAACTTTTtgagcatctgaTCGTCAAATAATCATGtgattgtcga a" /listShort="ywzH, dltA, dltB, dltC, dltD, S1480, dltE, ilvK" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3603158 /Source="Nicolas_upshifts" /id="U3035" /multdbtbs="SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2508 /SigmaFactorBS="cattttcaaaaacatacgccgatatattaatttgagggagat tagggaaaaaaTGAAACTTTTtgagcatctgaTCGTCAAATAATCATGtgattgtcga a" /listShort="ywzH, dltA, dltB, dltC, dltD, S1480, dltE, ilvK" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3603172..3603187 /Source="Nicolas_upshift_promotors" /id="U3035" /multdbtbs="SigX" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=2508 /SigmaFactorBS="cattttcaaaaacatacgccgatatattaatttgagggagat tagggaaaaaaTGAAACTTTTtgagcatctgaTCGTCAAATAATCATGtgattgtcga a" /listShort="ywzH, dltA, dltB, dltC, dltD, S1480, dltE, ilvK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3603194) /Source="Nicolas_upshifts" /id="U3036" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.976023976023976" /psig="0.001998001998002" /xcortree=298 /SigmaFactorBS="tttttcatacagctgtttcattaattgcagcatatcaaaaat tcCCTTCCCGTTTTTTCgacaatcacatgattatttgacgatcagatgctcaaaaagt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(3603196..3603210) /Source="Nicolas_upshift_promotors" /id="U3036" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.976023976023976" /psig="0.001998001998002" /xcortree=298 /SigmaFactorBS="tttttcatacagctgtttcattaattgcagcatatcaaaaat tcCCTTCCCGTTTTTTCgacaatcacatgattatttgacgatcagatgctcaaaaagt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS 3603222..3603371 /gene="ywzH" /locus_tag="BSU_38499" /old_locus_tag="BSU38499" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical membrane protein" /protein_id="YP_003097795.1" /db_xref="EnsemblGenomes-Gn:BSU38499" /db_xref="EnsemblGenomes-Tr:CAX52708" /db_xref="GOA:C0H3T3" /db_xref="InterPro:IPR021008" /db_xref="UniProtKB/Swiss-Prot:C0H3T3" /translation="MLQLMKQLYEKPAVKWTCHTGFYLMILLVLFFMYGFHTANTGSY IYNDF*" /label="ywzH CDS" gene 3603222..3603371 /gene="ywzH" /locus_tag="BSU_38499" /old_locus_tag="BSU38499" /label="ywzH gene" CDS 3603389..3604900 /gene="dltA" /locus_tag="BSU_38500" /old_locus_tag="BSU38500" /EC_number="6.1.1.13" /function="16.8: Protect" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7797557, 11222605, 14665680, 15955059, 18847223, 19324056, 23858088" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7797557, 11222605, 14665680, 15955059, 18847223, 19324056, 23858088; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-alanine:D-alanyl-carrier protein ligase subunit" /protein_id="NP_391729.1" /db_xref="EnsemblGenomes-Gn:BSU38500" /db_xref="EnsemblGenomes-Tr:CAB15876" /db_xref="GOA:P39581" /db_xref="InterPro:IPR000873" /db_xref="InterPro:IPR010071" /db_xref="InterPro:IPR010072" /db_xref="InterPro:IPR020845" /db_xref="InterPro:IPR025110" /db_xref="PDB:3E7W" /db_xref="PDB:3E7X" /db_xref="SubtiList:BG10551" /db_xref="UniProtKB/Swiss-Prot:P39581" /translation="MKLLHAIQTHAETYPQTDAFRSQGQSLTYQELWEQSDRAAAAIQ KRISGEKKSPILVYGHMEPHMIVSFLGSVKAGHPYIPVDLSIPSERIAKIIESSGAEL LIHAAGLSIDAVGQQIQTVSAEELLENEGGSVSQDQWVKEHETFYIIYTSGSTGNPKG VQISAANLQSFTDWICADFPVSGGKIFLNQAPFSFDLSVMDLYPCLQSGGTLHCVTKD AVNKPKVLFEELKKSGLNVWTSTPSFVQMCLMDPGFSQDLLPHADTFMFCGEVLPVSV AKALLERFPKAKIFNTYGPTEATVAVTSVEITNDVISRSESLPVGFAKPDMNIFIMDE EGQPLPEGEKGEIVIAGPSVSRGYLGEPELTEKAFFSHEGQWAYRTGDAGFIQDGQIF CQGRLDFQIKLHGYRMELEEIEFHVRQSQYVRSAVVIPYQPNGTVEYLIAAIVPEEHE FEKEFQLTSAIKKELAASLPAYMIPRKFIYQDHIQMTANGKIDRKRIGEEVLV*" /label="dltA CDS" gene 3603389..3604900 /gene="dltA" /locus_tag="BSU_38500" /old_locus_tag="BSU38500" /label="dltA gene" CDS 3604897..3606084 /gene="dltB" /locus_tag="BSU_38510" /old_locus_tag="BSU38510" /function="16.1: Circulate" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11222605, 12028417, 14665680, 15849754, 16850406, 17263852; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="putative D-alanine transferase from DCP to undecaprenylphosphate for lipoteichoic acid and wall teichoic acid" /protein_id="NP_391730.1" /db_xref="EnsemblGenomes-Gn:BSU38510" /db_xref="EnsemblGenomes-Tr:CAB15877" /db_xref="GOA:P39580" /db_xref="InterPro:IPR004299" /db_xref="InterPro:IPR024024" /db_xref="InterPro:IPR024194" /db_xref="SubtiList:BG10550" /db_xref="UniProtKB/Swiss-Prot:P39580" /translation="MTPYSSFLFFILLGILLLPTIILGLNGKRFQAYNMFISIIILAL IFSHDLHGVIALCLFTIWQVLLISGYLAYRQKANSGFVFCGAVIASILPLFLSKIWPF LSHPQPHHPPHNLISFLGISYLTFKGVQLIMEARDGLLKEQLPLHRLLYFILFFPTIS SGPIDRYRRFVKDEQKAWTKEEYADLLYTGIHKIFIGFLYKFIIGYAINTYFIMNLPA ITHNKILGNLLYMYGYSMYLFFDFAGYTMFAVGVSYIMGIKSPENFNKPFISKNIKDF WNRWHMSLSFWFRDYVFMRFVFWMTKKKWIKNRMAVSNIGYFLLFMLMGVWHGLAPQY IIYGLYHAVLMTCYNFFEKWNKKYKWLPSNRWTTILAIVITFHFVCFGFYIFSGKPFH HHH*" /label="dltB CDS" gene 3604897..3606084 /gene="dltB" /locus_tag="BSU_38510" /old_locus_tag="BSU38510" /label="dltB gene" CDS 3606101..3606337 /gene="dltC" /locus_tag="BSU_38520" /old_locus_tag="BSU38520" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7797557, 11222605, 14665680, 15955059, 26193422" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7797557, 11222605, 14665680, 15955059, 26193422; Product type c: carrier" /codon_start=1 /transl_table=11 /product="D-alanyl carrier protein" /protein_id="NP_391731.1" /db_xref="EnsemblGenomes-Gn:BSU38520" /db_xref="EnsemblGenomes-Tr:CAB15878" /db_xref="GOA:P39579" /db_xref="InterPro:IPR003230" /db_xref="InterPro:IPR009081" /db_xref="InterPro:IPR036736" /db_xref="PDB:4BPF" /db_xref="PDB:4BPG" /db_xref="PDB:4BPH" /db_xref="SubtiList:BG10549" /db_xref="UniProtKB/Swiss-Prot:P39579" /translation="MDFKQEVLDVLAEVCQDDIVKENPDIEIFEEGLLDSFGTVELLL AIENRFDILVPITEFDRDVWNTPNNIVNQLSELK*" /label="dltC CDS" gene 3606101..3606337 /gene="dltC" /locus_tag="BSU_38520" /old_locus_tag="BSU38520" /label="dltC gene" CDS 3606337..3607515 /gene="dltD" /locus_tag="BSU_38530" /old_locus_tag="BSU38530" /function="16.2: Construct biomass (Anabolism)" /function="16.13: Shape" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11222605, 12028417, 14665680, 17263852, 17600057, 23858088; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="putative D-alanine from undecaprenylphosphate tothe polyglycerolphosphate chain for lipoteichoic acid andwall teichoic acid synthesis" /protein_id="NP_391732.1" /db_xref="EnsemblGenomes-Gn:BSU38530" /db_xref="EnsemblGenomes-Tr:CAB15879" /db_xref="GOA:P39578" /db_xref="InterPro:IPR006998" /db_xref="InterPro:IPR023896" /db_xref="InterPro:IPR036514" /db_xref="SubtiList:BG10548" /db_xref="UniProtKB/Swiss-Prot:P39578" /translation="MKKRFFGPIILAFILFAGAIAIPSSWLTGFITDKRVKESATALN PSMFQGLYLQDQMLKDPTYLPIYGSSELSRLDEFHPSNYFQVNNEGFTPYLVGKGGSQ SLIHSLNFAAHMDQLKGKKIVFIVSPQWFIKRGSDEQHFAPNYSALQGLDLAFNDQID PEIKKKMMKRMLRFKAVQNDAILSELYKAMVNGQTWKVNALKPAAKVYYSMLEKKDLY YSTTESSGPKRYISQSVKDKSWSELNKLADQSGKRHSGSNDFHIDNPVYKKLKPKVPK LKGKNKGRSYAVSPEYGDFEMMLDILKDAGAEPMFVTIPVNGKWYDYTGFPKKGRTDY YKKVNKQIRAKGFQVADFSGHEYDPYFMKDTIHIGWKGWVYVDKAIDEFYKTGKVTSS *" /label="dltD CDS" gene 3606337..3607515 /gene="dltD" /locus_tag="BSU_38530" /old_locus_tag="BSU38530" /label="dltD gene" S_feature 3607516..3607605 /Source="Nicolas_S_feature" /locus_tag="new_3956402_3956491" /HighExp="Paraq, H2O2, Oxctl, LBGexp, Lbexp, dia0, C30, Cold, G150, LPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig="0.998" /label="S1480" CDS 3607606..3608364 /gene="dltE" /locus_tag="BSU_38540" /old_locus_tag="BSU38540" /EC_number="1.-.-.-" /function="16.8: Protect" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 7797557, 14665680; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391733.2" /db_xref="EnsemblGenomes-Gn:BSU38540" /db_xref="EnsemblGenomes-Tr:CAB15880" /db_xref="GOA:P39577" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10547" /db_xref="UniProtKB/Swiss-Prot:P39577" /translation="MKMTNNTVLITGGSAGIGLELAKRLLELGNEVIICGRSEARLAE AKQQLPNIHTKQCDVADRSQREALYEWALKEYPNLNVLVNNAGIQKEIDFKKGTEELF VDGDEIELNFQAPVHLSALFTPHLMKQPEAAIVQVTSGLAFNPLAVYPVYCATKAALH SFSLTLRHQLRDTSVEVIEMAPPMVDTGLNQKSRDKQGLTYRGISSEEYVQYFLDGLK EGKQEITNERVEGLRDATRADYDRLFEQMNTQEN*" /label="dltE CDS" gene 3607606..3608364 /gene="dltE" /locus_tag="BSU_38540" /old_locus_tag="BSU38540" /label="dltE gene" downshifts 3608332 /Source="Nicolas_upshifts" /id="D1997" /incds=0 /nref=48 /ntot=172 /MaxReadThrough="5.94016" /MaxDrop="4.72547" /score="22.6844301" /energy="-13.7" /TU="U3035" /idTUdmin="U3035" /TUdmin="-1254" /isTUend="FALSE" /label="downshifts" S_feature complement(3608366..3609593) /Source="Nicolas_S_feature" /locus_tag="new_3957252_3958479_c" /HighExp="T0.30H, T1.0H, T1.30H, C30, B60, T2.0H, C90, Gly, T2.30H, S8" /AntisenseName="ilvK" /AntisenseCor="-0.12928749136401099" /AntisenseRegPval="-1.5" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.978" /TUlongSig="NA" /TUlongPSig="NA" /label="S1481" promotor_-35 3608412..3608419 /Source="Nicolas_upshift_promotors" /id="U3037" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.82017982017982" /psig="0.999000999001" /xcortree=3073 /SigmaFactorBS="gaatttcttacaaatttgagcaaaccTATTGCGAttatttgt tgaagGTATACAATAGAATATAATTattttcaaataagtttgataatataaacaattt a" /listShort="ilvK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3608433..3608452 /Source="Nicolas_upshift_promotors" /id="U3037" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.82017982017982" /psig="0.999000999001" /xcortree=3073 /SigmaFactorBS="gaatttcttacaaatttgagcaaaccTATTGCGAttatttgt tgaagGTATACAATAGAATATAATTattttcaaataagtttgataatataaacaattt a" /listShort="ilvK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3608446 /Source="Nicolas_upshifts" /id="U3037" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.82017982017982" /psig="0.999000999001" /xcortree=3073 /SigmaFactorBS="gaatttcttacaaatttgagcaaaccTATTGCGAttatttgt tgaagGTATACAATAGAATATAATTattttcaaataagtttgataatataaacaattt a" /listShort="ilvK" /GFF_Attribute="listLong" /label="upshifts" CDS 3608505..3609596 /gene="ilvK" /locus_tag="BSU_38550" /old_locus_tag="BSU38550" /EC_number="2.6.1.42" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12670965, 17611193, 22938038" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12670965, 17611193, 22938038; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="branched-chain amino acid aminotransferase" /protein_id="NP_391734.2" /db_xref="EnsemblGenomes-Gn:BSU38550" /db_xref="EnsemblGenomes-Tr:CAB15881" /db_xref="GOA:P39576" /db_xref="InterPro:IPR001544" /db_xref="InterPro:IPR005786" /db_xref="InterPro:IPR018300" /db_xref="InterPro:IPR033939" /db_xref="InterPro:IPR036038" /db_xref="SubtiList:BG10546" /db_xref="UniProtKB/Swiss-Prot:P39576" /translation="MTKQTIRVELTSTKKPKPDPNQLSFGRVFTDHMFVMDYAADKGW YDPRIIPYQPLSMDPAAMVYHYGQTVFEGLKAYVSEDDHVLLFRPEKNMERLNQSNDR LCIPQIDEEQVLEGLKQLVAIDKDWIPNAEGTSLYIRPFIIATEPFLGVAASHTYKLL IILSPVGSYYKEGIKPVKIAVESEFVRAVKGGTGNAKTAGNYASSLKAQQVAEEKGFS QVLWLDGIEKKYIEEVGSMNIFFKINGEIVTPMLNGSILEGITRNSVIALLKHWGLQV SERKIAIDEVIQAHKDGILEEAFGTGTAAVISPVGELIWQDETLSINNGETGEIAKKL YDTITGIQKGAVADEFGWTTEVAALTESK*" /label="ilvK CDS" gene 3608505..3609596 /gene="ilvK" /locus_tag="BSU_38550" /old_locus_tag="BSU38550" /label="ilvK gene" downshifts 3609498 /Source="Nicolas_upshifts" /id="D1998" /incds=1 /nref=10 /ntot=90 /MaxReadThrough="6.0829" /MaxDrop="3.1965" /score="32.8755878" /energy="-13.6" /TU="U3035,U3037" /idTUdmin="U3035" /TUdmin="-88" /isTUend="FALSE" /label="downshifts" downshifts 3609586 /Source="Nicolas_upshifts" /id="D1999" /incds=0 /nref=157 /ntot=264 /MaxReadThrough="2.21106" /MaxDrop="6.83094" /score="32.8755878" /energy="-13.6" /TU="NA" /idTUdmin="U3035" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3609630..3610958) /gene="licH" /locus_tag="BSU_38560" /old_locus_tag="BSU38560" /EC_number="3.2.1.86" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 8990303, 10438772, 22720735, 23874669, 24673833; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="6-phospho-beta-glucosidase" /protein_id="NP_391735.1" /db_xref="EnsemblGenomes-Gn:BSU38560" /db_xref="EnsemblGenomes-Tr:CAB15882" /db_xref="GOA:P46320" /db_xref="InterPro:IPR001088" /db_xref="InterPro:IPR015955" /db_xref="InterPro:IPR019802" /db_xref="InterPro:IPR022616" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11350" /db_xref="UniProtKB/Swiss-Prot:P46320" /translation="MTKGLKIVTIGGGSSYTPELVEGFIKRYDELPVRELWLVDIPEG EEKLNIVGTLAKRMVEKAGVPIDIHLTLDRRKALKDADFVTTQFRVGLLQARAKDERI PLKYGVIGQETNGPGGLFKGLRTIPVILEIAKDIEELCPNAWLVNFTNPAGMVTEALL RYSNLKKVVGLCNVPIGIKMGVAKALDVDVDRVEVQFAGLNHMVFGLDVFLDGVSVKE QVIEAMGDPKNAMTMKNISGAEWEPDFLKALNVIPCGYHRYYFKTKEMLEHELEASQT EGTRAEVVQKVEKELFELYKDPNLAIKPPQLEKRGGAYYSDAACNLISSIYNDKHDIQ PVNTINNGAIASIPDDSAVEVNCVMTKTGPKPIAVGDLPVSVRGLVQQIKSFERVAAE AAVTGDYQTALLAMTINPLVPSDTVAKQILDEMLEAHKAYLPQFFNKIEA*" /label="licH CDS" gene complement(3609630..3610958) /gene="licH" /locus_tag="BSU_38560" /old_locus_tag="BSU38560" /label="licH gene" downshifts complement(3609638) /Source="Nicolas_upshifts" /id="D2000" /incds=0 /nref=12 /ntot=98 /MaxReadThrough="4.92442" /MaxDrop="6.75565" /score="45.1562234" /energy="-15.7" /TU="U3038" /idTUdmin="U3038" /TUdmin="-152" /isTUend="FALSE" /label="downshifts" CDS complement(3610955..3611287) /gene="licA" /locus_tag="BSU_38570" /old_locus_tag="BSU38570" /function="16.1: Circulate" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8990303, 10438772, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8990303, 10438772, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) lichenan-specific enzyme IIA component" /protein_id="NP_391736.1" /db_xref="EnsemblGenomes-Gn:BSU38570" /db_xref="EnsemblGenomes-Tr:CAB15883" /db_xref="GOA:P46319" /db_xref="InterPro:IPR003188" /db_xref="InterPro:IPR036542" /db_xref="SubtiList:BG11349" /db_xref="UniProtKB/Swiss-Prot:P46319" /translation="MNEEMEQIIFQIILHGGNGRSSAMEAIAAAKSGDAEEARKKLQD AAEELSKAHHYQTELIQNEAGGEKTEMTLLMVHAQDHLMNAMTVKDMAAEIIELYEKI TEQRGASI*" /label="licA CDS" gene complement(3610955..3611287) /gene="licA" /locus_tag="BSU_38570" /old_locus_tag="BSU38570" /label="licA gene" CDS complement(3611306..3612664) /gene="licC" /locus_tag="BSU_38580" /old_locus_tag="BSU38580" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8990303, 10438772, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8990303, 10438772, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) lichenan-specific enzyme IIC component" /protein_id="NP_391737.1" /db_xref="EnsemblGenomes-Gn:BSU38580" /db_xref="EnsemblGenomes-Tr:CAB15884" /db_xref="GOA:P46317" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR004501" /db_xref="InterPro:IPR004796" /db_xref="SubtiList:BG11348" /db_xref="UniProtKB/Swiss-Prot:P46317" /translation="MNKVNQILEEKVMPIAGRIAGQRHLQALRDGIILTMPLIIIGSF FLIIGNLPIPGYAEFMAKTFGSSWSEKLAYPVDATFEIMGLVAAFGIAYRLAEKYGVD ALSAGAISLAAFLLATPYQVPFMPDGATKEIMVGGGIPLSLMGSKGLFVAMIIAMVST EIYRLIIQRNLVFKMPDGVPPAVSKSFVALIPGFAVIFLIWAARLIVEATPFESLHNI VSVLLGTPLSILGGSLGGSLVAEAVKMLLWACGLHGANIVGGVMAPIWYGAMDANRIA FQAGEELPKIFTQQFFDIWVNIGGSGATLALVVTMFLRARSKQMKQLGKLAVGPAIFN INEPIIFGMPIVMNPMLLLPFIITPLVTVTLTYIGMSTGLVAKPAGIAVPWTMPPIFS GYLATGGKVSGAVMQAINIAVSFVVYYPFFRMWDKQKLKEENDLELVQTPAATDDKEA AL*" /label="licC CDS" gene complement(3611306..3612664) /gene="licC" /locus_tag="BSU_38580" /old_locus_tag="BSU38580" /label="licC gene" CDS complement(3612680..3612988) /gene="licB" /locus_tag="BSU_38590" /old_locus_tag="BSU38590" /EC_number="2.7.1.-" /function="16.1: Circulate" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8990303, 10438772, 23874669" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8990303, 10438772, 23874669; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) lichenan-specific enzyme IIB component" /protein_id="NP_391738.1" /db_xref="EnsemblGenomes-Gn:BSU38590" /db_xref="EnsemblGenomes-Tr:CAB15885" /db_xref="GOA:P46318" /db_xref="InterPro:IPR003501" /db_xref="InterPro:IPR013012" /db_xref="InterPro:IPR036095" /db_xref="SubtiList:BG11347" /db_xref="UniProtKB/Swiss-Prot:P46318" /translation="MNILLVCAAGMSTSLLVSKMEKSAQEQGKDYTIWAVSGDSVQNH IDKADVLLLGPQVRYMLPQLKKLGESKGVPVDVINTVHYGTCNGAEVLKSAEQLGHVS *" /label="licB CDS" gene complement(3612680..3612988) /gene="licB" /locus_tag="BSU_38590" /old_locus_tag="BSU38590" /label="licB gene" promotor_-10 complement(3613033..3613052) /Source="Nicolas_upshift_promotors" /id="U3038" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig="0.978021978021978" /xcortree=354 /SigmaFactorBS="tatataccttttttccgttgcctgcggaaaaaccctgAGTGT TTatgaaagcgatttCATAATATGATGATAGCAACagcaggacattacaaaattgatc a" /listShort="licB, licC, licA, licH, S1481" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3613049) /Source="Nicolas_upshifts" /id="U3038" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig="0.978021978021978" /xcortree=354 /SigmaFactorBS="tatataccttttttccgttgcctgcggaaaaaccctgAGTGT TTatgaaagcgatttCATAATATGATGATAGCAACagcaggacattacaaaattgatc a" /listShort="licB, licC, licA, licH, S1481" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3613066..3613072) /Source="Nicolas_upshift_promotors" /id="U3038" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig="0.978021978021978" /xcortree=354 /SigmaFactorBS="tatataccttttttccgttgcctgcggaaaaaccctgAGTGT TTatgaaagcgatttCATAATATGATGATAGCAACagcaggacattacaaaattgatc a" /listShort="licB, licC, licA, licH, S1481" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3613117) /Source="Nicolas_upshifts" /id="D2001" /incds=0 /nref=3 /ntot=74 /MaxReadThrough="3.19679" /MaxDrop="2.70222" /score="27.6067633" /energy="-11.1" /TU="U3040" /idTUdmin="U3040" /TUdmin="-45" /isTUend="FALSE" /label="downshifts" CDS complement(3613117..3615042) /gene="licR" /locus_tag="BSU_38600" /old_locus_tag="BSU38600" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8990303, 9353933, 10438772" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8990303, 9353933, 10438772; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional activator of the lichenan operon" /protein_id="NP_391739.1" /db_xref="EnsemblGenomes-Gn:BSU38600" /db_xref="EnsemblGenomes-Tr:CAB15886" /db_xref="GOA:P46321" /db_xref="InterPro:IPR002178" /db_xref="InterPro:IPR007737" /db_xref="InterPro:IPR011608" /db_xref="InterPro:IPR013011" /db_xref="InterPro:IPR013196" /db_xref="InterPro:IPR016152" /db_xref="InterPro:IPR036095" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="InterPro:IPR036634" /db_xref="SubtiList:BG11346" /db_xref="UniProtKB/Swiss-Prot:P46321" /translation="MLHGRLRDILRLLMAAEAPVTSSFFAAQLNVTTRTVRNDIKELQ GVLSGHGAFVQSVRGSGYKLRIDDEQVFRTLLQDEFQQKKGLPVLPEERMAYLMKRLL LADHYLKLDELAEELFISKSTLQTDLKEVKKRLLPYRIVMETRPNYGFKLRGDEVQMR YCMAEYIVDERETEIDVLNEKADILPKEEIEIIRSAILKKMKNDRIPLSNMGLNNLII HIAIACKRIRTENYVSLFPKDMDHILHQKEYQAAEAIVKELESKLSVTFPKDETAYIT MHLLGTKRMTQSQCGEDTFSIEEETDQLTLAMIKAVDRELKLGILHDKELKIGLALHM KPAISRNRYGMNLRNPMLAAIKEHYPLAFEAGIIAGIVIKEQTGIEIHENEIGYLALH FGAAIERKKTESPPKRCIIVCASGAGSAQLLREKLRSHFGKRLDILGTAEYYSLDQMS YESIDFVISTIPIKKELPVPVLKVNTILGGTDFTKIESILSDEKEKANRYLKKELVFF QEDLRSKEEVIQFLGQKVVECGFADEEIIDSIFEREDMSPTCFGNLVAIPHPLVPQTK TTFWAVCTLKKPIDWESQRVQFVCLLCVEKENKADLQSMYKLLGSILDDPAAMNQLIK CRSYQELSDVFDQKMLS*" /label="licR CDS" gene complement(3613117..3615042) /gene="licR" /locus_tag="BSU_38600" /old_locus_tag="BSU38600" /label="licR gene" promotor_-35 3613780..3613789 /Source="Nicolas_upshift_promotors" /id="U3039" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1369 /SigmaFactorBS="aaatgggaacgcagtttttcgcgcagaagCTGGGCGCTTccg gctcccgatgCGCATACAATGATACAGCGTttcggcgggctttctgttttttttcgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3613803..3613822 /Source="Nicolas_upshift_promotors" /id="U3039" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1369 /SigmaFactorBS="aaatgggaacgcagtttttcgcgcagaagCTGGGCGCTTccg gctcccgatgCGCATACAATGATACAGCGTttcggcgggctttctgttttttttcgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3613811 /Source="Nicolas_upshifts" /id="U3039" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1369 /SigmaFactorBS="aaatgggaacgcagtttttcgcgcagaagCTGGGCGCTTccg gctcccgatgCGCATACAATGATACAGCGTttcggcgggctttctgttttttttcgtt c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3615115..3615132) /Source="Nicolas_upshift_promotors" /id="U3040" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.699300699300699" /psig=1 /xcortree=3153 /SigmaFactorBS="gctgtttttttataggtcagttttccctctagtcctccggat gttCATTGACTtgccattctctccaTTATAGAATTTATATACAtttcgcatcccttca t" /listShort="licR" /listLong="licB, licC, licA, licH" /label="promotor_-10" upshifts complement(3615139) /Source="Nicolas_upshifts" /id="U3040" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.699300699300699" /psig=1 /xcortree=3153 /SigmaFactorBS="gctgtttttttataggtcagttttccctctagtcctccggat gttCATTGACTtgccattctctccaTTATAGAATTTATATACAtttcgcatcccttca t" /listShort="licR" /listLong="licB, licC, licA, licH" /label="upshifts" promotor_-35 complement(3615147..3615154) /Source="Nicolas_upshift_promotors" /id="U3040" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.699300699300699" /psig=1 /xcortree=3153 /SigmaFactorBS="gctgtttttttataggtcagttttccctctagtcctccggat gttCATTGACTtgccattctctccaTTATAGAATTTATATACAtttcgcatcccttca t" /listShort="licR" /listLong="licB, licC, licA, licH" /label="promotor_-35" CDS complement(3615205..3615363) /gene="yxzF" /locus_tag="BSU_38610" /old_locus_tag="BSU38610" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391740.1" /db_xref="EnsemblGenomes-Gn:BSU38610" /db_xref="EnsemblGenomes-Tr:CAB15887" /db_xref="SubtiList:BG14169" /db_xref="UniProtKB/Swiss-Prot:O32283" /translation="MVEKKEGRIGALKKMIKTVIKWAPVIYPIVRKIMKDRKASKQKN MSASRTAG*" /label="yxzF CDS" gene complement(3615205..3615363) /gene="yxzF" /locus_tag="BSU_38610" /old_locus_tag="BSU38610" /label="yxzF gene" downshifts complement(3615232) /Source="Nicolas_upshifts" /id="D2002" /incds=0 /nref=75 /ntot=208 /MaxReadThrough="0.739420000000001" /MaxDrop="6.4099" /score="27.6067633" /energy="-11.1" /TU="NA" /idTUdmin="U3041" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" CDS complement(3615392..3615982) /gene="aag" /locus_tag="BSU_38620" /old_locus_tag="BSU38620" /EC_number="3.2.2.-" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:14729667, 27698084" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14729667, 27698084; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3-alkylated purines and hypoxanthine DNA glycosidase" /protein_id="NP_391741.1" /db_xref="EnsemblGenomes-Gn:BSU38620" /db_xref="EnsemblGenomes-Tr:CAB15888" /db_xref="GOA:P94378" /db_xref="InterPro:IPR003180" /db_xref="InterPro:IPR011034" /db_xref="InterPro:IPR036995" /db_xref="SubtiList:BG12555" /db_xref="UniProtKB/Swiss-Prot:P94378" /translation="MTREKNPLPITFYQKTALELAPSLLGCLLVKETDEGTASGYIVE TEAYMGAGDRAAHSFNNRRTKRTEIMFAEAGRVYTYVMHTHTLLNVVAAEEDVPQAVL IRAIEPHEGQLLMEERRPGRSPREWTNGPGKLTKALGVTMNDYGRWITEQPLYIESGY TPEAISTGPRIGIDNSGEARDYPWRFWVTGNRYVSR*" /label="aag CDS" gene complement(3615392..3615982) /gene="aag" /locus_tag="BSU_38620" /old_locus_tag="BSU38620" /label="aag gene" promotor_-10 complement(3616010..3616028) /Source="Nicolas_upshift_promotors" /id="U3041" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.921078921078921" /psig="0.921078921078921" /xcortree=132 /SigmaFactorBS="aatattccctgaatggaaagattttaaaacagcCGTTTTTtt tgatctgcttcGGGAATGGTACAATGTACAaaaatcggtaaaaggagaggtcgattcg t" /listShort="aag, yxzF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3616021) /Source="Nicolas_upshifts" /id="U3041" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.921078921078921" /psig="0.921078921078921" /xcortree=132 /SigmaFactorBS="aatattccctgaatggaaagattttaaaacagcCGTTTTTtt tgatctgcttcGGGAATGGTACAATGTACAaaaatcggtaaaaggagaggtcgattcg t" /listShort="aag, yxzF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3616042..3616048) /Source="Nicolas_upshift_promotors" /id="U3041" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.921078921078921" /psig="0.921078921078921" /xcortree=132 /SigmaFactorBS="aatattccctgaatggaaagattttaaaacagcCGTTTTTtt tgatctgcttcGGGAATGGTACAATGTACAaaaatcggtaaaaggagaggtcgattcg t" /listShort="aag, yxzF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3616051..3616057 /Source="Nicolas_upshift_promotors" /id="U3042" /multdbtbs="SigB,SigF" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=727 /SigmaFactorBS="ttgtaccattcccgaagcagatcaaaaaaaacggcTGTTTTA aaatctttccattcaGGGAATATTGTTACCGTTCaaaaaaggagggccaaccattgaa a" /listShort="katX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3616073..3616091 /Source="Nicolas_upshift_promotors" /id="U3042" /multdbtbs="SigB,SigF" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=727 /SigmaFactorBS="ttgtaccattcccgaagcagatcaaaaaaaacggcTGTTTTA aaatctttccattcaGGGAATATTGTTACCGTTCaaaaaaggagggccaaccattgaa a" /listShort="katX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3616076 /Source="Nicolas_upshifts" /id="U3042" /multdbtbs="SigB,SigF" /comp="M11" /sig="SigB" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=727 /SigmaFactorBS="ttgtaccattcccgaagcagatcaaaaaaaacggcTGTTTTA aaatctttccattcaGGGAATATTGTTACCGTTCaaaaaaggagggccaaccattgaa a" /listShort="katX" /GFF_Attribute="listLong" /label="upshifts" CDS 3616111..3617754 /gene="katX" /locus_tag="BSU_38630" /old_locus_tag="BSU38630" /EC_number="1.11.1.6" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:9393707, 9555886, 10503549, 24123749" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9393707, 9555886, 10503549, 24123749; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="major catalase in spores" /protein_id="NP_391742.1" /db_xref="EnsemblGenomes-Gn:BSU38630" /db_xref="EnsemblGenomes-Tr:CAB15889" /db_xref="GOA:P94377" /db_xref="InterPro:IPR002226" /db_xref="InterPro:IPR010582" /db_xref="InterPro:IPR011614" /db_xref="InterPro:IPR018028" /db_xref="InterPro:IPR020835" /db_xref="InterPro:IPR024708" /db_xref="InterPro:IPR024711" /db_xref="InterPro:IPR037060" /db_xref="SubtiList:BG11945" /db_xref="UniProtKB/Swiss-Prot:P94377" /translation="MKDDHQNKQHQSNAQGSEEAFSHKTSGKNESEDTLTNRQGHPVT DNQNVRTVGNRGPTTLENYDFLEKISHFDRERIPERVVHARGAGAHGYFEAYGSFGDE PISTYTRAKLFQEKGKKTPAFVRFSTVNHGKHSPETLRDPRGFAVKLYTEDGNWDLVG NNLKIFFIRDPLKFPDLVHAFQPDPVTNIQDGERIFDFISQSPEATHMITFLFSPWGI PANYRQMQGSGVHAYKWVNEEGKAVLVKYHFEPKQGIRNLTQKEAEEIQGKNFNHATQ DLYDAIENGDYPEWEVYAQIMSDDEHPELDFDPLDPTKLWYKDDFPWKPIGKLVLNKN PENYHAEVEQASFGTGVLVDGLDFSDDKLLQGRTFAYSDTQRYRVGANYLQLPINSPK KHVATNQEGGQMQYRVDRAEGQNPHVNYEPSIMGGLKEAKQDGKDHTPHVEGDVKREA IDRTNNFGQAGETYRRFTEFERNELITNLVNTLSTCRKEIQDQMIENFTKADPDYGKR VAEGLKKVSENNSNGPIGTTETEQAAKQAEQESHPSDPY*" /label="katX CDS" gene 3616111..3617754 /gene="katX" /locus_tag="BSU_38630" /old_locus_tag="BSU38630" /label="katX gene" S_feature complement(3616248..3617797) /Source="Nicolas_S_feature" /locus_tag="new_3965134_3966683_c" /HighExp="T0.30H, T1.0H, T1.30H, T2.0H, T2.30H, T3.0H, S8, T3.30H, S6, T0.0H" /AntisenseName="katX" /AntisenseCor="0.28909015498211399" /AntisenseRegPval="-5.8" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1482" downshifts 3617749 /Source="Nicolas_upshifts" /id="D2003" /incds=0 /nref=28 /ntot=49 /MaxReadThrough="0.942820000000001" /MaxDrop="5.69337" /score="45.0252072" /energy="-12.7" /TU="NA" /idTUdmin="U3042" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(3617799..3617890) /Source="Nicolas_S_feature" /locus_tag="new_3966685_3966776_c" /HighExp="T0.30H, T1.30H, T1.0H, T2.0H, T2.30H, T3.30H, T4.0H, T3.0H, T0.0H, T5.0H" /AntisenseName="yxlH" /AntisenseCor="-4.8005444617814199E-3" /AntisenseRegPval=0 /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1483" promotor_-35 3617801..3617807 /Source="Nicolas_upshift_promotors" /id="U3043" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig="0.914085914085914" /xcortree=1556 /SigmaFactorBS="caacagcgaacagggcttttttagaagccctgtttttttatt tttcTATTGAAacgctttcaataatTGTGTTGTACTTGGAAGGAAaggggtggagaga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3617815 /Source="Nicolas_upshifts" /id="U3043" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig="0.914085914085914" /xcortree=1556 /SigmaFactorBS="caacagcgaacagggcttttttagaagccctgtttttttatt tttcTATTGAAacgctttcaataatTGTGTTGTACTTGGAAGGAAaggggtggagaga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3617822..3617841 /Source="Nicolas_upshift_promotors" /id="U3043" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.45954045954046" /psig="0.914085914085914" /xcortree=1556 /SigmaFactorBS="caacagcgaacagggcttttttagaagccctgtttttttatt tttcTATTGAAacgctttcaataatTGTGTTGTACTTGGAAGGAAaggggtggagaga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" downshifts complement(3617842) /Source="Nicolas_upshifts" /id="D2004" /incds=0 /nref=8 /ntot=42 /MaxReadThrough="3.81662" /MaxDrop="3.1285" /score="-7.60062702" /energy="-7.5" /TU="U3045" /idTUdmin="U3045" /TUdmin="-1557" /isTUend="FALSE" /label="downshifts" CDS 3617859..3619061 /gene="yxlH" /locus_tag="BSU_38640" /old_locus_tag="BSU38640" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14769884, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_391743.1" /db_xref="EnsemblGenomes-Gn:BSU38640" /db_xref="EnsemblGenomes-Tr:CAB15890" /db_xref="GOA:P94376" /db_xref="InterPro:IPR001958" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG12554" /db_xref="UniProtKB/Swiss-Prot:P94376" /translation="MELQQDLIPQKKTIGALDHAVFLCMVFCFWFSGYIYVPVFSLYL EDLHFSYGAIGIILGSYGVTQILLRFPLGLLSDILFSLRKQLLIAGFGFSVLSSLLFL MFDSFFFVLAARLFAGITASTWVMATILYAHYFNNGNASKAMGIMQFFTVMPQFASIV FCGLAAAHLGRQVPFWMALAASAAGLVICCFIQDPSAPPANRGTIRVNQYIKDTLRLP KLKLFTILSMTAHAVLFITVFGFTPLYMNQLGMGDAELLWVMSAFFLPHAAATLSFVF LRFTSRIAYSVMLISFAVTGVCLLYVPFLAALFTVCITHACIGLALGFVFPLLLSHVV EISSARLKMSVMGFYQSFYALGIFLGPLLAGKIAQLIGLAGVFYGAGSLAFAAFFVML AQKRNMIN*" /label="yxlH CDS" gene 3617859..3619061 /gene="yxlH" /locus_tag="BSU_38640" /old_locus_tag="BSU38640" /label="yxlH gene" S_feature complement(3617892..3619057) /Source="Nicolas_S_feature" /locus_tag="new_3966778_3967943_c" /HighExp="T1.0H, T1.30H, T0.30H, T2.0H, T2.30H, T0.0H, T3.0H, T3.30H, T-0.40H, T4.0H" /AntisenseName="yxlH" /AntisenseCor="-4.5703316381945601E-2" /AntisenseRegPval="-0.3" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1484" downshifts complement(3617935) /Source="Nicolas_upshifts" /id="D2005" /incds=1 /nref=3 /ntot=61 /MaxReadThrough="6.44992" /MaxDrop="2.92619" /score="-7.60062702" /energy="-7.5" /TU="U3045" /idTUdmin="U3045" /TUdmin="-1650" /isTUend="FALSE" /label="downshifts" CDS complement(3619058..3619834) /gene="yxlG" /locus_tag="BSU_38650" /old_locus_tag="BSU38650" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14769884, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC-transporter (permease)" /protein_id="NP_391744.2" /db_xref="EnsemblGenomes-Gn:BSU38650" /db_xref="EnsemblGenomes-Tr:CAB15891" /db_xref="GOA:P94375" /db_xref="InterPro:IPR032688" /db_xref="SubtiList:BG12553" /db_xref="UniProtKB/Swiss-Prot:P94375" /translation="MKVMMALLQKEWLEGWKSGKLIWLPIAMMIVGLTQPLTIYYMPE IIAHGGNLPDGMKISFTMPSGSEVMVSTLSQFNTLGMALVIFSVMGSVANERNQGVTA LIMSRPVTAAHYIVSKWLIQSVIGIMSFAAGYGLAYYYVRLLFEDASFSRFAASLGLY ALWVIFIVTAGLAGSTIFRSVGAAAACGIGLTAAVSFAVSLFPDGAKWLPAEICKQAE HILLHGERADFFGWSLTFSILCIMLLAVFSVWRFRRYESY*" /label="yxlG CDS" gene complement(3619058..3619834) /gene="yxlG" /locus_tag="BSU_38650" /old_locus_tag="BSU38650" /label="yxlG gene" CDS complement(3619831..3620718) /gene="yxlF" /locus_tag="BSU_38660" /old_locus_tag="BSU38660" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12897008, 14769884, 14993308; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter component (ATP-binding protein)" /protein_id="NP_391745.1" /db_xref="EnsemblGenomes-Gn:BSU38660" /db_xref="EnsemblGenomes-Tr:CAB15892" /db_xref="GOA:P94374" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR025302" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG12552" /db_xref="UniProtKB/Swiss-Prot:P94374" /translation="MLSIESLCKSYRHHEAVKNVSFHVNENECVALLGPNGAGKTTTL QMLAGLLSPTSGTIKLLGEKKLDRRLIGYLPQYPAFYSWMTANEFLTFAGRLSGLSKR KCQEKIGEMLEFVGLHEAAHKRIGGYSGGMKQRLGLAQALLHKPKFLILDEPVSALDP TGRFEVLDMMRELKKHMAVLFSTHVLHDAEQVCDQVVIMKNGEISWKGELQELKQQQQ TNVFTLSVKEKLEGWLEEKPYVSAIVYKNPSQAVFELPDIHAGRSLLSDCIRKGLTVT RFEQKTESLEDVYLKVVHA*" /label="yxlF CDS" gene complement(3619831..3620718) /gene="yxlF" /locus_tag="BSU_38660" /old_locus_tag="BSU38660" /label="yxlF gene" CDS complement(3620725..3620913) /gene="yxlE" /locus_tag="BSU_38670" /old_locus_tag="BSU38670" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12897008, 14769884, 14993308" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12897008, 14769884, 14993308; Product type r: regulator" /codon_start=1 /transl_table=11 /product="negative regulator of sigma-Y activity" /protein_id="NP_391746.1" /db_xref="EnsemblGenomes-Gn:BSU38670" /db_xref="EnsemblGenomes-Tr:CAB15893" /db_xref="GOA:P94373" /db_xref="InterPro:IPR027379" /db_xref="SubtiList:BG12551" /db_xref="UniProtKB/Swiss-Prot:P94373" /translation="MNISWEMILPLIVLQLALAVFALISCIKEERTNGPKWMWAAIIV CINIIGPILFFTVGRKQR*" /label="yxlE CDS" gene complement(3620725..3620913) /gene="yxlE" /locus_tag="BSU_38670" /old_locus_tag="BSU38670" /label="yxlE gene" CDS complement(3620910..3621116) /gene="yxlD" /locus_tag="BSU_38680" /old_locus_tag="BSU38680" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12897008, 14769884, 14993308; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative sigma-Y antisigma factor component" /protein_id="NP_391747.1" /db_xref="EnsemblGenomes-Gn:BSU38680" /db_xref="EnsemblGenomes-Tr:CAB15894" /db_xref="GOA:P94372" /db_xref="SubtiList:BG12550" /db_xref="UniProtKB/Swiss-Prot:P94372" /translation="MTQTEIIITVAACLIVLAQGIFLFIDAKKRNHMAWVWGIVGLIQ APMPLICYYFFVIRPDRKKRGIKQ*" /label="yxlD CDS" gene complement(3620910..3621116) /gene="yxlD" /locus_tag="BSU_38680" /old_locus_tag="BSU38680" /label="yxlD gene" CDS complement(3621113..3621433) /gene="yxlC" /locus_tag="BSU_38690" /old_locus_tag="BSU38690" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12897008, 14769884, 14993308" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12897008, 14769884, 14993308; Product type r: regulator" /codon_start=1 /transl_table=11 /product="sigma-Y antisigma factor" /protein_id="NP_391748.1" /db_xref="EnsemblGenomes-Gn:BSU38690" /db_xref="EnsemblGenomes-Tr:CAB15895" /db_xref="GOA:P94371" /db_xref="InterPro:IPR035238" /db_xref="SubtiList:BG12549" /db_xref="UniProtKB/Swiss-Prot:P94371" /translation="MNKEKLSDHLKSEWKKIDQTANPSIPNQKELLHQLSQMKAEYRK KLLQEIILFVFCALMVVSAAILAFTQAPAVFIVLQVCVLAVLPILIAAEKKRHLGECE VKRG*" /label="yxlC CDS" gene complement(3621113..3621433) /gene="yxlC" /locus_tag="BSU_38690" /old_locus_tag="BSU38690" /label="yxlC gene" promotor_-35 3621246..3621255 /Source="Nicolas_upshift_promotors" /id="U3044" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1366 /SigmaFactorBS="aacacagcaggagcttgagtgaaagctaagattgcaGCACTC ACAAccatcagcgcgcAGAATACAAATAAAATGATCtcttgaagaagtttttttctgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3621268..3621287 /Source="Nicolas_upshift_promotors" /id="U3044" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1366 /SigmaFactorBS="aacacagcaggagcttgagtgaaagctaagattgcaGCACTC ACAAccatcagcgcgcAGAATACAAATAAAATGATCtcttgaagaagtttttttctgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3621270 /Source="Nicolas_upshifts" /id="U3044" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=1366 /SigmaFactorBS="aacacagcaggagcttgagtgaaagctaagattgcaGCACTC ACAAccatcagcgcgcAGAATACAAATAAAATGATCtcttgaagaagtttttttctgt a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3621426..3621962) /gene="sigY" /locus_tag="BSU_38700" /old_locus_tag="BSU38700" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12897008, 14769884, 14993308" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12897008, 14769884, 14993308; Product type r: regulator" /codon_start=1 /transl_table=11 /product="RNA polymerase ECF (extracytoplasmic function)-type sigma factor (sigma-Y)" /protein_id="NP_391749.1" /db_xref="EnsemblGenomes-Gn:BSU38700" /db_xref="EnsemblGenomes-Tr:CAB15896" /db_xref="GOA:P94370" /db_xref="InterPro:IPR000838" /db_xref="InterPro:IPR007627" /db_xref="InterPro:IPR013249" /db_xref="InterPro:IPR013324" /db_xref="InterPro:IPR013325" /db_xref="InterPro:IPR014284" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11975" /db_xref="UniProtKB/Swiss-Prot:P94370" /translation="MDTQEEQRLIQQAKEGNDEAFTALFHYHYSFLYKYLLKLSLHPD LSEELVQETFLKGYIHLRSFQGRSKFSTWLISIASRLYLDHQKKRKREWKRNQTVTEE TIRKIKWDVSAKGAEWSETLDLFSKLDPKLRTPVLLRHYYGYTYAEIGVMLQIKEGTV KSRVHKGLQQIRKEWDDE*" /label="sigY CDS" gene complement(3621426..3621962) /gene="sigY" /locus_tag="BSU_38700" /old_locus_tag="BSU38700" /label="sigY gene" upshifts complement(3621990) /Source="Nicolas_upshifts" /id="U3045" /multdbtbs="SigY" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1710 /SigmaFactorBS="gctgaaaagaattgtaaaaaagaTGAACGCTTTtgaatccgg tgTCGTCTCATAAGGCAGaaaaacaaaaaaggggggatcacggtcattggatacacaa g" /listShort="sigY, yxlC, yxlD, yxlE, yxlF, yxlG, S1484, S1483, S1482" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3621991..3622006) /Source="Nicolas_upshift_promotors" /id="U3045" /multdbtbs="SigY" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1710 /SigmaFactorBS="gctgaaaagaattgtaaaaaagaTGAACGCTTTtgaatccgg tgTCGTCTCATAAGGCAGaaaaacaaaaaaggggggatcacggtcattggatacacaa g" /listShort="sigY, yxlC, yxlD, yxlE, yxlF, yxlG, S1484, S1483, S1482" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3622018..3622027) /Source="Nicolas_upshift_promotors" /id="U3045" /multdbtbs="SigY" /comp="M9" /sig="SigWXY" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1710 /SigmaFactorBS="gctgaaaagaattgtaaaaaagaTGAACGCTTTtgaatccgg tgTCGTCTCATAAGGCAGaaaaacaaaaaaggggggatcacggtcattggatacacaa g" /listShort="sigY, yxlC, yxlD, yxlE, yxlF, yxlG, S1484, S1483, S1482" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3622093..3622100 /Source="Nicolas_upshift_promotors" /id="U3046" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.993006993006993" /xcortree=2429 /SigmaFactorBS="aggcttcccggccgtttggctgcatatcctTATTTGTAaacc cccttatagTCTGTTAAGCTATGACTTTAtgtcgatttcaaaaaaacatccaatatgg a" /listShort="yxlA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3622114..3622133 /Source="Nicolas_upshift_promotors" /id="U3046" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.993006993006993" /xcortree=2429 /SigmaFactorBS="aggcttcccggccgtttggctgcatatcctTATTTGTAaacc cccttatagTCTGTTAAGCTATGACTTTAtgtcgatttcaaaaaaacatccaatatgg a" /listShort="yxlA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3622123 /Source="Nicolas_upshifts" /id="U3046" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.993006993006993" /xcortree=2429 /SigmaFactorBS="aggcttcccggccgtttggctgcatatcctTATTTGTAaacc cccttatagTCTGTTAAGCTATGACTTTAtgtcgatttcaaaaaaacatccaatatgg a" /listShort="yxlA" /GFF_Attribute="listLong" /label="upshifts" CDS 3622174..3623547 /gene="yxlA" /locus_tag="BSU_38710" /old_locus_tag="BSU38710" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 2191181, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative purine-cytosine (pyridoxine) permease" /protein_id="NP_391750.1" /db_xref="EnsemblGenomes-Gn:BSU38710" /db_xref="EnsemblGenomes-Tr:CAB15897" /db_xref="GOA:P94369" /db_xref="InterPro:IPR001248" /db_xref="InterPro:IPR026030" /db_xref="SubtiList:BG12548" /db_xref="UniProtKB/Swiss-Prot:P94369" /translation="MKVERRTIEYIPNEERHGKAKDLFPVWFGANMHITTLVTGTIPV AMGLNLFWSVAAIICGTLIGAIFMASHSAQGPQLGIPQMIQSRAQFGVIGAILPLFLV MFIYLGFFASSTILAAGTLSSFVPIPGSWSIIGLSAVCFLLTIFGHDLIHKMQKILSW TSFAVFFAATILIFQLPIPAGSWIPGAIDLPIFLVAVSAVATWQLAYAPYVADYSRYL PVKTPASKTFWYSYAGTSVSSIWMMLLGALLTTSLPDFTANSGSQIVQLFGPFSFIML IIVLFGQMAINVFNLYGAFMSTTTTLEPFLKLKVTPKVRIIMILGVTLVGTVLSLLGQ SNFMELFLNFIFFISYFLIPWTAINLVDYYFVRHGKYQVKAMFDVNGPYGKVNWITTI AFVLSILLEIPFINTSFYIGPLAKMFGGGDIAWIIGLAVPSVLYYVLMKPRLKKRAGY QEKLSSL*" /label="yxlA CDS" gene 3622174..3623547 /gene="yxlA" /locus_tag="BSU_38710" /old_locus_tag="BSU38710" /label="yxlA gene" S_feature complement(3622454..3622996) /Source="Nicolas_S_feature" /locus_tag="new_3971340_3971882_c" /HighExp="Etha, LBGstat, T1.0H, T0.30H, Diami, T1.30H, dia15, G150, G135, G180" /AntisenseName="yxlA" /AntisenseCor="-8.6586358833710395E-2" /AntisenseRegPval="-0.8" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1485" promotor_-10 complement(3622984..3623003) /Source="Nicolas_upshift_promotors" /id="U3047" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98101898101898" /psig="0.996003996003996" /xcortree=1813 /SigmaFactorBS="aagccccatacaggttaaaaacattgattgcCATTTGCCcaa atagcacaatgATCAGCATAATAAACGAGAAgggaccgaacaattggacaatctggct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3622996) /Source="Nicolas_upshifts" /id="U3047" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98101898101898" /psig="0.996003996003996" /xcortree=1813 /SigmaFactorBS="aagccccatacaggttaaaaacattgattgcCATTTGCCcaa atagcacaatgATCAGCATAATAAACGAGAAgggaccgaacaattggacaatctggct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3623018..3623025) /Source="Nicolas_upshift_promotors" /id="U3047" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.98101898101898" /psig="0.996003996003996" /xcortree=1813 /SigmaFactorBS="aagccccatacaggttaaaaacattgattgcCATTTGCCcaa atagcacaatgATCAGCATAATAAACGAGAAgggaccgaacaattggacaatctggct g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3623382 /Source="Nicolas_upshifts" /id="D2006" /incds=1 /nref=30 /ntot=136 /MaxReadThrough="1.87017" /MaxDrop="3.59478" /score="22.3054019" /energy="-12.9" /TU="NA" /idTUdmin="U3046" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3623562..3624392) /gene="nnrA" /locus_tag="BSU_38720" /old_locus_tag="BSU38720" /function="16.8: Protect" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:12457846, 21994945, 22940582, 25393291" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12457846, 21994945, 22940582, 25393291; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="NAD(P)H dehydratase" /protein_id="NP_391751.1" /db_xref="EnsemblGenomes-Gn:BSU38720" /db_xref="EnsemblGenomes-Tr:CAB15898" /db_xref="GOA:P94368" /db_xref="InterPro:IPR000631" /db_xref="InterPro:IPR017953" /db_xref="InterPro:IPR029056" /db_xref="PDB:1KYH" /db_xref="PDB:3RPH" /db_xref="PDB:3RPZ" /db_xref="PDB:3RQ2" /db_xref="PDB:3RQ5" /db_xref="PDB:3RQ6" /db_xref="PDB:3RQ8" /db_xref="PDB:3RQH" /db_xref="PDB:3RQQ" /db_xref="PDB:3RQX" /db_xref="SubtiList:BG12547" /db_xref="UniProtKB/Swiss-Prot:P94368" /translation="MNVPFWTEEHVRATLPERDAESHKGTYGTALLLAGSDDMPGAAL LAGLGAMRSGLGKLVIGTSENVIPLIVPVLPEATYWRDGWKKAADAQLEETYRAIAIG PGLPQTESVQQAVDHVLTADCPVILDAGALAKRTYPKREGPVILTPHPGEFFRMTGVP VNELQKKRAEYAKEWAAQLQTVIVLKGNQTVIAFPDGDCWLNPTGNGALAKGGTGDTL TGMILGMLCCHEDPKHAVLNAVYLHGACAELWTDEHSAHTLLAHELSDILPRVWKRFE *" /label="nnrA CDS" gene complement(3623562..3624392) /gene="nnrA" /locus_tag="BSU_38720" /old_locus_tag="BSU38720" /label="nnrA gene" downshifts complement(3623568) /Source="Nicolas_upshifts" /id="D2007" /incds=0 /nref=3 /ntot=52 /MaxReadThrough="3.50755" /MaxDrop="3.84264" /score="7.61210868" /energy="-12.9" /TU="U3048" /idTUdmin="U3051" /TUdmin=792 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3624411..3624429) /Source="Nicolas_upshift_promotors" /id="U3048" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=168 /SigmaFactorBS="gtaaaataaaagacagccctaaaaggctgtctttttTGTTTG AaaaagaaaagggacAGGAAAAATAGGAAAAGAAagcagaggagggatagagatgaat g" /listShort="yxkO, S1485" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3624426) /Source="Nicolas_upshifts" /id="U3048" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=168 /SigmaFactorBS="gtaaaataaaagacagccctaaaaggctgtctttttTGTTTG AaaaagaaaagggacAGGAAAAATAGGAAAAGAAagcagaggagggatagagatgaat g" /listShort="yxkO, S1485" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3624444..3624450) /Source="Nicolas_upshift_promotors" /id="U3048" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=168 /SigmaFactorBS="gtaaaataaaagacagccctaaaaggctgtctttttTGTTTG AaaaagaaaagggacAGGAAAAATAGGAAAAGAAagcagaggagggatagagatgaat g" /listShort="yxkO, S1485" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3624470) /Source="Nicolas_upshifts" /id="U3049" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.973026973026973" /psig="0.98101898101898" /xcortree=2119 /SigmaFactorBS="cggcaaacgaacgatatcgccgcctgtatcaccttgatgTTC CTGTAAAATAAAAGACAgccctaaaaggctgtcttttttgtttgaaaaagaaaaggga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(3624472..3624491) /Source="Nicolas_upshift_promotors" /id="U3049" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.973026973026973" /psig="0.98101898101898" /xcortree=2119 /SigmaFactorBS="cggcaaacgaacgatatcgccgcctgtatcaccttgatgTTC CTGTAAAATAAAAGACAgccctaaaaggctgtcttttttgtttgaaaaagaaaaggga c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" CDS complement(3624478..3626205) /gene="cydD" /locus_tag="BSU_38730" /old_locus_tag="BSU38730" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9852001, 10551842, 15231791, 16040611, 26517902, 26699904; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC membrane transporter (ATP-binding protein) required for cytochrome bb' function (reductant efflux pump)" /protein_id="NP_391752.1" /db_xref="EnsemblGenomes-Gn:BSU38730" /db_xref="EnsemblGenomes-Tr:CAB15899" /db_xref="GOA:P94367" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR014223" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG11928" /db_xref="UniProtKB/Swiss-Prot:P94367" /translation="MKKEEWILPYIKQNARLFVLVIFLGAVTIFSAAFLMFTSGFLIS KAATRPENILLIYVPIVAVRTFGIARSVSRYVERLVGHHIILKIVSDMRVRLYNMLEP GALMLRSRFRTGDMLGILSEDIEHLQDAFLKTIFPAISALLLYAVSVIALGFFSWPFA ILLALYLFVLVVLFPVVSLLVTRAKNAKLKSGRNVLYSRLTDAVMGVSDWMFSGRRHA FIDAYEKEERDWFELERKKQRFTRWRDFAAQCLVAGLILLMLFWTAGQQADGELAKTM IAAFVLVVFPLTEAFLPLSDALGEVPGYQDSIRRMNNVAPQPEASQTESGDQILDLQD VTLAFRDVTFSYDNSSQVLHNFSFTLRQGEKMALLGRSGSGKSTSLALIEGALKPDSG SVTLNGVETALLKDQIADAVAVLNQKPHLFDTSILNNIRLGNGEASDEDVRRAAKQVK LHDYIESLPDGYHTSVQETGIRFSGGERQRIALARILLQDTPIIILDEPTVGLDPITE RELMETVFEVLKGKTILWITHHLAGVEAADKIVFLENGKTEMEGTHEELLAANERYRR LYHLDVPVK*" /label="cydD CDS" gene complement(3624478..3626205) /gene="cydD" /locus_tag="BSU_38730" /old_locus_tag="BSU38730" /label="cydD gene" downshifts complement(3624577) /Source="Nicolas_upshifts" /id="D2008" /incds=1 /nref=7 /ntot=46 /MaxReadThrough="5.39758" /MaxDrop="3.66431" /score="25.0271963" /energy="-10.6" /TU="U3051" /idTUdmin="U3051" /TUdmin="-217" /isTUend="FALSE" /label="downshifts" CDS complement(3626202..3627905) /gene="cydC" /locus_tag="BSU_38740" /old_locus_tag="BSU38740" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9852001, 10551842, 15231791, 16040611, 26517902, 26699904; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC membrane transporter (ATP-binding protein) required for cytochrome bb' function (reductant efflux pump)" /protein_id="NP_391753.1" /db_xref="EnsemblGenomes-Gn:BSU38740" /db_xref="EnsemblGenomes-Tr:CAB15900" /db_xref="GOA:P94366" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR011527" /db_xref="InterPro:IPR014216" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036640" /db_xref="SubtiList:BG11927" /db_xref="UniProtKB/Swiss-Prot:P94366" /translation="MGKDLFRYKGMKRILTLITCLTLIQTAAIIMQAEWLSEAVTGLF NGKGITSLLPVIGFFLIAFIARHGMTVARQKIVYQYAARTGADLRKSFLDQLFRLGPR FAKKEGTGQMVTLAMEGISQFRRYLELFLPKMVSMAIVPAAVVIYVFFQDRTSAIILV AAMPILIIFMILLGLVAQRKADRQWKSYQRLSNHFVDSLRGLETLRFLGLSKSHSKNI FYVSERYRKATMSTLRVAFLSSFALDFFTMLSVATVAVFLGLRLIDGDILLGPALTAL ILAPEYFLPVREVGNDYHATLNGQEAGKTIQEILSQPGFKEETPLQLEAWSDQDELKL SGVSVGRSVSDIHLSFKGKKKIGIIGASGAGKSTLIDILGGFLEPDGGMIEVNGTSRS HLQDGSWQKNLLYIPQHPYIFDDTLGNNIRFYHPSASAEDTTRAAASAGLTELVNNLP DGLEGRIGEGGRALSGGQAQRVALARAFLGNRPILLLDEPTAHLDIETEYEIKETMLD LFEDKLVFLATHRLHWMLDMDEIIVLDGGRVAEIGTHNELLEKNGVYTKLVKAQLGER A*" /label="cydC CDS" gene complement(3626202..3627905) /gene="cydC" /locus_tag="BSU_38740" /old_locus_tag="BSU38740" /label="cydC gene" CDS complement(3627905..3628921) /gene="cydB" /locus_tag="BSU_38750" /old_locus_tag="BSU38750" /EC_number="1.10.3.-" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:9852001, 10551842, 15231791, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9852001, 10551842, 15231791, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome bb' ubiquinol oxidase (subunit II)" /protein_id="NP_391754.1" /db_xref="EnsemblGenomes-Gn:BSU38750" /db_xref="EnsemblGenomes-Tr:CAB15901" /db_xref="GOA:P94365" /db_xref="InterPro:IPR003317" /db_xref="SubtiList:BG11926" /db_xref="UniProtKB/Swiss-Prot:P94365" /translation="MASLHDLWFILVAVLFVGFFFLEGFDFGVGMATRFLGHNELERR VLINTIGPFWDANEVWLLTGAGAIFAAFPNWYATMLSGYYIPFVIVLLALMGRGVAFE FRGKVDHLKWVKVWDWVVFFGSLIPPFVLGVLFTTLFRGMPIDADMNIHAHVSDYINV YSILGGVTVTLLCFQHGLMFITLRTIGDLQNRARKMAQKIMGVVFVAVLAFAALSAYQ TDMFTRRGEITIPLAVLIVICFMLAAVFIRKKKDGWTFGMTGAGLALTVGMIFISLFP RVMVSSLHSAYDLTVANASSGDYSLKVMSIAALTLLPFVIGSQIWSYYVFRKRVSHKE PMTY*" /label="cydB CDS" gene complement(3627905..3628921) /gene="cydB" /locus_tag="BSU_38750" /old_locus_tag="BSU38750" /label="cydB gene" promotor_-10 complement(3628795..3628813) /Source="Nicolas_upshift_promotors" /id="U3050" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.963036963036963" /psig="0.963036963036963" /xcortree=1107 /SigmaFactorBS="ttctttttggaaggctttgatttcggggtcGGCATGgcgacc cgttttcttGGCCATAATGAATTAGAACgcagagtgctgatcaacacgatcgggccgt t" /listShort="cydC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3628804) /Source="Nicolas_upshifts" /id="U3050" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.963036963036963" /psig="0.963036963036963" /xcortree=1107 /SigmaFactorBS="ttctttttggaaggctttgatttcggggtcGGCATGgcgacc cgttttcttGGCCATAATGAATTAGAACgcagagtgctgatcaacacgatcgggccgt t" /listShort="cydC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3628829..3628834) /Source="Nicolas_upshift_promotors" /id="U3050" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.963036963036963" /psig="0.963036963036963" /xcortree=1107 /SigmaFactorBS="ttctttttggaaggctttgatttcggggtcGGCATGgcgacc cgttttcttGGCCATAATGAATTAGAACgcagagtgctgatcaacacgatcgggccgt t" /listShort="cydC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3628905..3630311) /gene="cydA" /locus_tag="BSU_38760" /old_locus_tag="BSU38760" /EC_number="1.10.3.-" /function="16.10: Respire" /experiment="publication(s) with functional evidences, PMID:9852001, 10551842, 15231791, 15849754, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9852001, 10551842, 15231791, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cytochrome bb' ubiquinol oxidase (subunit I)" /protein_id="NP_391755.1" /db_xref="EnsemblGenomes-Gn:BSU38760" /db_xref="EnsemblGenomes-Tr:CAB15902" /db_xref="GOA:P94364" /db_xref="InterPro:IPR002585" /db_xref="SubtiList:BG11925" /db_xref="UniProtKB/Swiss-Prot:P94364" /translation="MSELVLARIQFASTTLFHFLFVPMSIGLVFMVALMETLYLVKKN ELYLKMAKFWGHLFLINFAVGVVTGILQEFQFGLNWSDYSRFVGDVFGAPLAIEALLA FFMESIFIGLWIFGWDRLPKKIHALCIWLVSFGTIMSSFWILTANSFMQEPVGFTIKN GRAEMNDFGALITNPQLWVEFPHVIFGALATGAFFIAGVSAFKLLKKKEVPFFKQSFK LAMIVGLCAGLGVGLSGHMQAEHLMESQPMKMAASEGLWEDSGDPAAWTAFATIDTKN EKSSNEIKVPYALSYLAYQKFSGSVKGMKTLQAEYEKIYGKGDYIPPVKTTFWSFRIM VGAGVVMILAALGGLWLNRRKKLENSKWYLRIMIALISFPFLANSAGWIMTEIGRQPW TVMGLMTTAQSVSPNVTAGSLLFSIIAFGVMYMILGALLVFLFIREIKKGAEHDNHHD VPVSTDPFSQEVYHGISS*" /label="cydA CDS" gene complement(3628905..3630311) /gene="cydA" /locus_tag="BSU_38760" /old_locus_tag="BSU38760" /label="cydA gene" S_feature complement(3630312..3630520) /Source="Nicolas_S_feature" /locus_tag="new_3979198_3979406_c" /HighExp="M0t45, ferm, UNK1, Gly, Lbexp, Lbstat, dia0, nit, M/G, M40t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.999, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1486" promotor_-10 complement(3630503..3630522) /Source="Nicolas_upshift_promotors" /id="U3051" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.276723276723277" /psig="0.999000999001" /xcortree=1601 /SigmaFactorBS="aatccgtcacatagtgcgggactttttaggtattttaggCTT TATttttgaaatgaatCGTTGTAAAGTACTTAATATgaaccagtcagagattgtgtca t" /listShort="S1486, cydA, cydB, cydC, cydD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3630520) /Source="Nicolas_upshifts" /id="U3051" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.276723276723277" /psig="0.999000999001" /xcortree=1601 /SigmaFactorBS="aatccgtcacatagtgcgggactttttaggtattttaggCTT TATttttgaaatgaatCGTTGTAAAGTACTTAATATgaaccagtcagagattgtgtca t" /listShort="S1486, cydA, cydB, cydC, cydD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3630522..3630630) /Source="Nicolas_S_feature" /locus_tag="new_3979408_3979516_c" /HighExp="LPhT, LBGtran, ferm, LBGstat, M0t45, dia0, Etha, dia5, Lbexp, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1487" promotor_-35 complement(3630536..3630541) /Source="Nicolas_upshift_promotors" /id="U3051" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.276723276723277" /psig="0.999000999001" /xcortree=1601 /SigmaFactorBS="aatccgtcacatagtgcgggactttttaggtattttaggCTT TATttttgaaatgaatCGTTGTAAAGTACTTAATATgaaccagtcagagattgtgtca t" /listShort="S1486, cydA, cydB, cydC, cydD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3630627..3630646) /Source="Nicolas_upshift_promotors" /id="U3052" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.713286713286713" /psig="0.996003996003996" /xcortree=1598 /SigmaFactorBS="ctgagactcgagtgctggggcgggggcaagcatttTGTTCGC AaggaacgatgtgtTGATGTACGATAATAAAGGGtcatttatcctagcagccgacata a" /listShort="S1487, S1486, cydA" /listLong="cydB, cydC, cydD" /label="promotor_-10" upshifts complement(3630642) /Source="Nicolas_upshifts" /id="U3052" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.713286713286713" /psig="0.996003996003996" /xcortree=1598 /SigmaFactorBS="ctgagactcgagtgctggggcgggggcaagcatttTGTTCGC AaggaacgatgtgtTGATGTACGATAATAAAGGGtcatttatcctagcagccgacata a" /listShort="S1487, S1486, cydA" /listLong="cydB, cydC, cydD" /label="upshifts" promotor_-35 complement(3630660..3630667) /Source="Nicolas_upshift_promotors" /id="U3052" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.713286713286713" /psig="0.996003996003996" /xcortree=1598 /SigmaFactorBS="ctgagactcgagtgctggggcgggggcaagcatttTGTTCGC AaggaacgatgtgtTGATGTACGATAATAAAGGGtcatttatcctagcagccgacata a" /listShort="S1487, S1486, cydA" /listLong="cydB, cydC, cydD" /label="promotor_-35" promotor_-35 3630788..3630795 /Source="Nicolas_upshift_promotors" /id="U3053" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.65034965034965" /psig="0.997002997002997" /xcortree=400 /SigmaFactorBS="tttgaaccggtaagaggagaaaagttgaatagtaaattttta aTATATTAAtaatttcaatttttTAGTATACTTAACATAGTGaacaatttcactgcat c" /listShort="cimH, yxkI" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3630805 /Source="Nicolas_upshifts" /id="U3053" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.65034965034965" /psig="0.997002997002997" /xcortree=400 /SigmaFactorBS="tttgaaccggtaagaggagaaaagttgaatagtaaattttta aTATATTAAtaatttcaatttttTAGTATACTTAACATAGTGaacaatttcactgcat c" /listShort="cimH, yxkI" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3630810..3630828 /Source="Nicolas_upshift_promotors" /id="U3053" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.65034965034965" /psig="0.997002997002997" /xcortree=400 /SigmaFactorBS="tttgaaccggtaagaggagaaaagttgaatagtaaattttta aTATATTAAtaatttcaatttttTAGTATACTTAACATAGTGaacaatttcactgcat c" /listShort="cimH, yxkI" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3630867..3632219 /gene="cimH" /locus_tag="BSU_38770" /old_locus_tag="BSU38770" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11566984, 12525174, 15849754, 16850406, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11566984, 12525174, 15849754, 16850406, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="citrate/malate/H+ symporter" /protein_id="NP_391756.1" /db_xref="EnsemblGenomes-Gn:BSU38770" /db_xref="EnsemblGenomes-Tr:CAB15903" /db_xref="GOA:P94363" /db_xref="InterPro:IPR004679" /db_xref="InterPro:IPR018025" /db_xref="SubtiList:BG12546" /db_xref="UniProtKB/Swiss-Prot:P94363" /translation="MGELQTHMQLQTDTIHEGVRKENWFAKAMNIKVGIIPLPVYALL FILITVFVMHHDVKSDILTSIAVMAFFGFTFAQIGKSIPIVRSIGGPAILATFIPSAV VYYHLLPNDIVKSTTEFTENSNFLYLFIAGIVVGSILGMKRETLVKAFMKIFIPLIVG SVTAAIVGLAVGTLLGLGFQHTLLYIVIPIMAGGVGEGAIPLSIGYSDIMPISQGEAF ALVLPSIMLGSLCAIILAGLLNRIGKKKPEWTGNGKVDRSEEESPALEESQSGQQMFN LSLFASGGILAVSLYLVGMLAHDFFGFPAPVAMLLLAVLIKLFRLVPASIENGAFGVS RFFSTAVTYPLLFAIGVSMTPWDKLVAAFNLSNIITILSVVVTMMAVGFFTGKWLNMY PIETAIINACHSGQGGTGDVAILSAAERLELMPFAQVSTRIGGAITVSLTLLLLHQFY *" /label="cimH CDS" gene 3630867..3632219 /gene="cimH" /locus_tag="BSU_38770" /old_locus_tag="BSU38770" /label="cimH gene" S_feature complement(3631818..3634300) /Source="Nicolas_S_feature" /locus_tag="new_3980704_3983186_c" /HighExp="Cold, C30, LBGstat, Paraq, GM 120, GM 90, H2O2, Oxctl, GM 25, GM 45" /AntisenseName="yxkI" /AntisenseCor="0.564471040461903" /AntisenseRegPval="-23.3" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1488" downshifts 3632204 /Source="Nicolas_upshifts" /id="D2009" /incds=0 /nref=63 /ntot=147 /MaxReadThrough="2.93791" /MaxDrop="3.97692" /score="3.68725156" /energy="-12.7" /TU="U3053" /idTUdmin="U3053" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" misc_feature 3632295..3632314 /Source="Nicolas_upshift_promotors" /id="U3054" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.892107892107892" /psig="0.999000999001" /xcortree=2291 /SigmaFactorBS="tcaaacgaaagagcttgcttttttgcatgtccatgtttttgc aagttcccatccCATGCTATAGTAATAGTTGGaaatactagatagaaaggaatctggc a" /listShort="yxkI" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3632301 /Source="Nicolas_upshifts" /id="U3054" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.892107892107892" /psig="0.999000999001" /xcortree=2291 /SigmaFactorBS="tcaaacgaaagagcttgcttttttgcatgtccatgtttttgc aagttcccatccCATGCTATAGTAATAGTTGGaaatactagatagaaaggaatctggc a" /listShort="yxkI" /GFF_Attribute="listLong" /label="upshifts" CDS 3632341..3634029 /gene="yxkI" /locus_tag="BSU_38780" /old_locus_tag="BSU38780" /EC_number="3.4.24.-" /function="16.8: Protect" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16845009; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative membrane protease" /protein_id="NP_391757.1" /db_xref="EnsemblGenomes-Gn:BSU38780" /db_xref="EnsemblGenomes-Tr:CAB15904" /db_xref="GOA:P94362" /db_xref="InterPro:IPR001915" /db_xref="SubtiList:BG12545" /db_xref="UniProtKB/Swiss-Prot:P94362" /translation="MPMGTHLFLFMLLGLGFYLISALAAKLIPAIDFWIDIVLWVGAA AYIFSHLSFMDGIVSLATMFYCYWTAMDLIVSERVEKPSGDWQEIELAKNKTRLLSDI TLTAIVFAGAVIFFIYGPDTSPLKYVILLGMISGGGALVKRILNVFSVKVFYSAALEK LHISSHYETRTYPLSDLKNIQLESTADLLKLHPLLTMYSSRLDLTTSFQQVIKLSLPG ETLFLTVKEPQKWKTILQEYTDAENNVDNVISVLPFYHRKNVKRLLGKLYFAASVKGV SAYALLVLALYALHASPWVMAVAVILYWVFNMYMSDRVLRAAMDAKSCHHPHVQAAAD KIFRSAGISHVRIYETESDDYNGMAVGMNVGRSMVILTSATLTLPQRVIEGILAHEAI HIKKRDVLSSQLLRFLYLGAVVGIFLLFEQHITHPEAHKIALWAFIMAIIILFQLYQS FCSQWMEVRADNLGASLLDGGYKQMAEALRILAVRQDEDIQKQSAYSSEAGEDELQID SLTRDKSWFFRLIDFQFAPHPPMYWRVGTLLSNKGHGVLKRWLRDRLKESITLK*" /label="yxkI CDS" gene 3632341..3634029 /gene="yxkI" /locus_tag="BSU_38780" /old_locus_tag="BSU38780" /label="yxkI gene" promotor_-35 3634027..3634036 /Source="Nicolas_upshift_promotors" /id="U3055" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1699 /SigmaFactorBS="tcagagaccgactgaaagaatcgatcactttgaaaTGAAACC GGTcagcgtttcatCCGTATAACAGATATGgtgaaaaaagggagtgacgcgaagtgat t" /listShort="yxzE, S1489" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3634048..3634063 /Source="Nicolas_upshift_promotors" /id="U3055" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1699 /SigmaFactorBS="tcagagaccgactgaaagaatcgatcactttgaaaTGAAACC GGTcagcgtttcatCCGTATAACAGATATGgtgaaaaaagggagtgacgcgaagtgat t" /listShort="yxzE, S1489" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3634052 /Source="Nicolas_upshifts" /id="U3055" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1699 /SigmaFactorBS="tcagagaccgactgaaagaatcgatcactttgaaaTGAAACC GGTcagcgtttcatCCGTATAACAGATATGgtgaaaaaagggagtgacgcgaagtgat t" /listShort="yxzE, S1489" /GFF_Attribute="listLong" /label="upshifts" CDS 3634087..3634287 /gene="yxzE" /locus_tag="BSU_38790" /old_locus_tag="BSU38790" /function="16.5: Explore" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16845009; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative bacteriocin" /protein_id="NP_391758.1" /db_xref="EnsemblGenomes-Gn:BSU38790" /db_xref="EnsemblGenomes-Tr:CAB15905" /db_xref="SubtiList:BG14168" /db_xref="UniProtKB/Swiss-Prot:O32284" /translation="MIVIILLFISIIVFLSVIQPQPSKNKSRQQADSGYFGYSDHSSH HDGCSSDGGFSDSGCGGGGGGD*" /label="yxzE CDS" gene 3634087..3634287 /gene="yxzE" /locus_tag="BSU_38790" /old_locus_tag="BSU38790" /label="yxzE gene" S_feature 3634288..3635232 /Source="Nicolas_S_feature" /locus_tag="new_3983174_3984118" /HighExp="T0.30H, T1.0H, T1.30H, T2.0H, T2.30H, T0.0H, T-0.40H, Salt, T3.30H, T3.0H" /AntisenseName="yxkH" /AntisenseCor="0.147753218660366" /AntisenseRegPval="-1.8" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1489" CDS complement(3634301..3635140) /gene="yxkH" /locus_tag="BSU_38800" /old_locus_tag="BSU38800" /EC_number="3.-.-.-" /function="16.8: Protect" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 22277649; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative exported polysaccharide deacetylase, lipoprotein" /protein_id="NP_391759.1" /db_xref="EnsemblGenomes-Gn:BSU38800" /db_xref="EnsemblGenomes-Tr:CAB15906" /db_xref="GOA:P94361" /db_xref="InterPro:IPR002509" /db_xref="InterPro:IPR011330" /db_xref="SubtiList:BG12544" /db_xref="UniProtKB/Swiss-Prot:P94361" /translation="MKRLFLSIFLLGSCLALAACADQEANAEQPMPKAEQKKPEKKAV QVQKKEDDTSAWIKTEKPAKLPILMYHSISSGNSLRVPKKEFEAHMKWLHDNGYQTLT PKEASLMLTQDKKPSEKCVLITFDDGYTDNYQDAYPVLKKYGMKATIFMIGKSIGHKH HLTEEQMKEMAQHGISIESHTIDHLELNGLTPQQQQSEMADSKKLFDNMFHQQTTIIS YPVGRYNEETLKAAEKTGYQMGVTTEPGAASRDQGMYALHRVRVSPGMSGSAFGAYIE SMK*" /label="yxkH CDS" gene complement(3634301..3635140) /gene="yxkH" /locus_tag="BSU_38800" /old_locus_tag="BSU38800" /label="yxkH gene" promotor_-10 complement(3635166..3635184) /Source="Nicolas_upshift_promotors" /id="U3056" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2813 /SigmaFactorBS="tcaaaaaaaccggacatggagacatgtccggttttttgctAT TGAAAAtctcagaatcaaACCGATGAAAAAGGAGGAAgaaatagacagaaagcaggag a" /listShort="yxkH, S1488" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3635184) /Source="Nicolas_upshifts" /id="U3056" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2813 /SigmaFactorBS="tcaaaaaaaccggacatggagacatgtccggttttttgctAT TGAAAAtctcagaatcaaACCGATGAAAAAGGAGGAAgaaatagacagaaagcaggag a" /listShort="yxkH, S1488" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3635197..3635204) /Source="Nicolas_upshift_promotors" /id="U3056" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2813 /SigmaFactorBS="tcaaaaaaaccggacatggagacatgtccggttttttgctAT TGAAAAtctcagaatcaaACCGATGAAAAAGGAGGAAgaaatagacagaaagcaggag a" /listShort="yxkH, S1488" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3635199 /Source="Nicolas_upshifts" /id="D2010" /incds=0 /nref=27 /ntot=142 /MaxReadThrough="0.40982" /MaxDrop="6.50242" /score="33.6694147" /energy="-13.4" /TU="NA" /idTUdmin="U3055" /TUdmin=3 /isTUend="TRUE" /label="downshifts" CDS complement(3635247..3636344) /gene="msmX" /locus_tag="BSU_38810" /old_locus_tag="BSU38810" /EC_number="3.6.3.-" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:16707683" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16707683; Product type t: transporter" /codon_start=1 /transl_table=11 /product="multiple sugar (maltodextrins) transporter ATP-binding protein" /protein_id="NP_391760.1" /db_xref="EnsemblGenomes-Gn:BSU38810" /db_xref="EnsemblGenomes-Tr:CAB15907" /db_xref="GOA:P94360" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR005116" /db_xref="InterPro:IPR008995" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11954" /db_xref="UniProtKB/Swiss-Prot:P94360" /translation="MAELRMEHIYKFYDQKEPAVDDFNLHIADKEFIVFVGPSGCGKS TTLRMVAGLEEISKGDFYIEGKRVNDVAPKDRDIAMVFQNYALYPHMTVYDNIAFGLK LRKMPKPEIKKRVEEAAKILGLEEYLHRKPKALSGGQRQRVALGRAIVRDAKVFLMDE PLSNLDAKLRVQMRAEIIKLHQRLQTTTIYVTHDQTEALTMATRIVVMKDGKIQQIGT PKDVYEFPENVFVGGFIGSPAMNFFKGKLTDGLIKIGSAALTVPEGKMKVLREKGYIG KEVIFGIRPEDIHDELIVVESYKNSSIKAKINVAELLGSEIMIYSQIDNQDFIARIDA RLDIQSGDELTVAFDMNKGHFFDSETEVRIR*" /label="msmX CDS" gene complement(3635247..3636344) /gene="msmX" /locus_tag="BSU_38810" /old_locus_tag="BSU38810" /label="msmX gene" downshifts complement(3635248) /Source="Nicolas_upshifts" /id="D2011" /incds=0 /nref=81 /ntot=171 /MaxReadThrough="3.31232" /MaxDrop="7.04855" /score="29.2689404" /energy="-14.4" /TU="U3057" /idTUdmin="U3058" /TUdmin=2 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3636377..3636396) /Source="Nicolas_upshift_promotors" /id="U3057" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.549450549450549" /psig="0.998001998001998" /xcortree=355 /SigmaFactorBS="tgcacgaaaaatggctgggtgattttatgaacgctgccCATT TTAGcgagagggaattGCTGTTACACTCAATATAAGaaagcgtttacaataacaaagg g" /listShort="msmX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3636394) /Source="Nicolas_upshifts" /id="U3057" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.549450549450549" /psig="0.998001998001998" /xcortree=355 /SigmaFactorBS="tgcacgaaaaatggctgggtgattttatgaacgctgccCATT TTAGcgagagggaattGCTGTTACACTCAATATAAGaaagcgtttacaataacaaagg g" /listShort="msmX" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3636396..3636464) /Source="Nicolas_S_feature" /locus_tag="new_3985282_3985350_c" /HighExp="M0t90, M40t90, Lbstat, Lbtran, T2.0H, dia5, T2.30H, M9-stat, S2, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1490" promotor_-35 complement(3636409..3636416) /Source="Nicolas_upshift_promotors" /id="U3057" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.549450549450549" /psig="0.998001998001998" /xcortree=355 /SigmaFactorBS="tgcacgaaaaatggctgggtgattttatgaacgctgccCATT TTAGcgagagggaattGCTGTTACACTCAATATAAGaaagcgtttacaataacaaagg g" /listShort="msmX" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3636465..3637358) /gene="yxkF" /locus_tag="BSU_38820" /old_locus_tag="BSU38820" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10746760" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10746760; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (regulates yxkF-msmX expression)" /protein_id="NP_391761.1" /db_xref="EnsemblGenomes-Gn:BSU38820" /db_xref="EnsemblGenomes-Tr:CAB15908" /db_xref="InterPro:IPR025736" /db_xref="SubtiList:BG12543" /db_xref="UniProtKB/Swiss-Prot:P94359" /translation="MKSLLAIYPGSIVSEELCIREGCLCFFDESNQRYISIPKTEISE KEVLVLQSFLTPADEGNQLSMKSPEENKWFSFLFSRGELPAYIKKRTRFVHFHLFGKI ERTSFTEAVRHFWPVSFVIVWIHEDRGVIVEQESEAAAEKDELESLAKVLESDFYFSV RFYAGRFYEPDECLRKHYAREQAYFLFAEKRLPQVQSVTFEMIFPFLLLETEKEKLET LLSEEAELLFGSESELRKTIKLFIENNSNVTLTAKKLHLHRNSLQYRIDKFIERSGID IKSYKGALLAYFICLQNESSE*" /label="yxkF CDS" gene complement(3636465..3637358) /gene="yxkF" /locus_tag="BSU_38820" /old_locus_tag="BSU38820" /label="yxkF gene" promotor_-10 complement(3637385..3637404) /Source="Nicolas_upshift_promotors" /id="U3058" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=3179 /SigmaFactorBS="ttcagtttctcgtctatctataccggatatactctttttTAG TGGAGaacatgtgtgtttCGCCTTATACTGAATATACAgatccttacataagagagga g" /listShort="yxkF, S1490, msmX" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3637404) /Source="Nicolas_upshifts" /id="U3058" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=3179 /SigmaFactorBS="ttcagtttctcgtctatctataccggatatactctttttTAG TGGAGaacatgtgtgtttCGCCTTATACTGAATATACAgatccttacataagagagga g" /listShort="yxkF, S1490, msmX" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3637418..3637425) /Source="Nicolas_upshift_promotors" /id="U3058" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.949050949050949" /psig=1 /xcortree=3179 /SigmaFactorBS="ttcagtttctcgtctatctataccggatatactctttttTAG TGGAGaacatgtgtgtttCGCCTTATACTGAATATACAgatccttacataagagagga g" /listShort="yxkF, S1490, msmX" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3637432..3637437 /Source="Nicolas_upshift_promotors" /id="U3059" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.93006993006993" /psig="0.93006993006993" /xcortree=1025 /SigmaFactorBS="gcgaaacacacatgttctccactaaaaaagAGTATAtccggt atagatagaCGAGAAACTGAAAGGGAAAcctcattcgtttacatattggcttcagcgg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3637453..3637471 /Source="Nicolas_upshift_promotors" /id="U3059" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.93006993006993" /psig="0.93006993006993" /xcortree=1025 /SigmaFactorBS="gcgaaacacacatgttctccactaaaaaagAGTATAtccggt atagatagaCGAGAAACTGAAAGGGAAAcctcattcgtttacatattggcttcagcgg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3637462 /Source="Nicolas_upshifts" /id="U3059" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.93006993006993" /psig="0.93006993006993" /xcortree=1025 /SigmaFactorBS="gcgaaacacacatgttctccactaaaaaagAGTATAtccggt atagatagaCGAGAAACTGAAAGGGAAAcctcattcgtttacatattggcttcagcgg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3637479..3637485 /Source="Nicolas_upshift_promotors" /id="U3060" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=249 /SigmaFactorBS="agatagacgagaaactgaaagggaaacctcattCGTTTACat attggcttcagcGGAAATAGAAGAAGACATGcaggaccaaaggagggtcatcttatga g" /listShort="aldY" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3637500..3637518 /Source="Nicolas_upshift_promotors" /id="U3060" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=249 /SigmaFactorBS="agatagacgagaaactgaaagggaaacctcattCGTTTACat attggcttcagcGGAAATAGAAGAAGACATGcaggaccaaaggagggtcatcttatga g" /listShort="aldY" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3637506 /Source="Nicolas_upshifts" /id="U3060" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=249 /SigmaFactorBS="agatagacgagaaactgaaagggaaacctcattCGTTTACat attggcttcagcGGAAATAGAAGAAGACATGcaggaccaaaggagggtcatcttatga g" /listShort="aldY" /GFF_Attribute="listLong" /label="upshifts" CDS 3637542..3638999 /gene="aldY" /locus_tag="BSU_38830" /old_locus_tag="BSU38830" /EC_number="1.2.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10482513; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aldehyde dehydrogenase" /protein_id="NP_391762.1" /db_xref="EnsemblGenomes-Gn:BSU38830" /db_xref="EnsemblGenomes-Tr:CAB15909" /db_xref="GOA:P94358" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="PDB:4DNG" /db_xref="SubtiList:BG11903" /db_xref="UniProtKB/Swiss-Prot:P94358" /translation="MSFETLNKSFINGKWTGGESGRTEDILNPYDQSVITTASLATGK QLEDAFDIAQKAQKEWAKSTTEDRKAVLQKARGYLHENRDDIIMMIARETGGTIIKST IELEQTIAILDEAMTYTGELGGVKEVPSDIEGKTNKIYRLPLGVISSISPFNFPMNLS MRSIAPAIALGNSVVHKPDIQTAISGGTIIAKAFEHAGLPAGVLNVMLTDVKEIGDGM LTNPIPRLISFTGSTAVGRHIGEIAGRAFKRMALELGGNNPFAVLSDADVDRAVDAAI FGKFIHQGQICMIINRIIVHQDVYDEFVEKFTARVKQLPYGDQTDPKTVVGPLINERQ IEKALEIIEQAKTDGIELAVEGKRVGNVLTPYVFVGADNNSKIAQTELFAPIATIIKA GSDQEAIDMANDTEYGLSSAVFTSDLEKGEKFALQIDSGMTHVNDQSVNDSPNIAFGG NKASGVGRFGNPWVVEEFTVTKWISIQKQYRKYPF*" /label="aldY CDS" gene 3637542..3638999 /gene="aldY" /locus_tag="BSU_38830" /old_locus_tag="BSU38830" /label="aldY gene" promotor_-10 complement(3638425..3638443) /Source="Nicolas_upshift_promotors" /id="U3061" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.894105894105894" /psig="0.894105894105894" /xcortree=1207 /SigmaFactorBS="gtttgatcgccgtacggaagctgtttgacacgggcggTGAAT TtttctacaaactcaTCGTATACATCTTGATGAAcgatgatcctgttgataatcatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3638440) /Source="Nicolas_upshifts" /id="U3061" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.894105894105894" /psig="0.894105894105894" /xcortree=1207 /SigmaFactorBS="gtttgatcgccgtacggaagctgtttgacacgggcggTGAAT TtttctacaaactcaTCGTATACATCTTGATGAAcgatgatcctgttgataatcatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3638458..3638463) /Source="Nicolas_upshift_promotors" /id="U3061" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.894105894105894" /psig="0.894105894105894" /xcortree=1207 /SigmaFactorBS="gtttgatcgccgtacggaagctgtttgacacgggcggTGAAT TtttctacaaactcaTCGTATACATCTTGATGAAcgatgatcctgttgataatcatac a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3638980 /Source="Nicolas_upshifts" /id="D2012" /incds=0 /nref=14 /ntot=39 /MaxReadThrough="1.43471" /MaxDrop="4.03346" /score="25.9343422" /energy="-13.8" /TU="NA" /idTUdmin="U3060" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts 3639024 /Source="Nicolas_upshifts" /id="D2013" /incds=0 /nref=1 /ntot=1 /MaxReadThrough="1.40793" /MaxDrop="3.07407" /score="25.9343422" /energy="-13.8" /TU="NA" /idTUdmin="U3060" /TUdmin=44 /isTUend="FALSE" /label="downshifts" CDS complement(3639041..3639877) /gene="gdnE" /locus_tag="BSU_38840" /old_locus_tag="BSU38840" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10735877, 10931887, 15096624, 15849754, 16850406, 21317561; Product type t : transporter" /codon_start=1 /transl_table=11 /product="guanidinium exporter" /protein_id="NP_391763.1" /db_xref="EnsemblGenomes-Gn:BSU38840" /db_xref="EnsemblGenomes-Tr:CAB15910" /db_xref="GOA:P94357" /db_xref="InterPro:IPR003740" /db_xref="InterPro:IPR019264" /db_xref="SubtiList:BG12542" /db_xref="UniProtKB/Swiss-Prot:P94357" /translation="MKKRMLDVLMLVIGAFFFALAVNLFAIPNDLGEGGVTGITLILY YLFQWSPGVTNFILNAFLLLIGYKFLDGKTTVYTIIAVAANSLFLHLTHGWSIPSDEL IINTIFAGVFAGVGIGMIIRVGGTTAGSAILARIANKYLDWNISYALLFFDLIVVFSS YFIIGAEKMMFTIVMLYIGTKVMDFIIEGLNTKKAITVISENKSEIAEQVNTLMDRGV TILSGKGNYTGQSKEILYIVINKQELSMLKKIIRSCDKKAFVIVHDVRDVFGEGFVDI SK*" /label="gdnE CDS" gene complement(3639041..3639877) /gene="gdnE" /locus_tag="BSU_38840" /old_locus_tag="BSU38840" /label="gdnE gene" downshifts complement(3639059) /Source="Nicolas_upshifts" /id="D2014" /incds=0 /nref=19 /ntot=137 /MaxReadThrough="1.00689" /MaxDrop="4.07213" /score="21.5028874" /energy="-13.8" /TU="NA" /idTUdmin="U3062" /TUdmin="-3" /isTUend="TRUE" /label="downshifts" misc_RNA complement(3639954..3640056) /gene="gdwB" /locus_tag="BSU_misc_RNA_60" /product="guanidine riboswitch (type I)" /experiment="publication(s) with functional evidences, PMID:21317561, 27989440, 28096518" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 21317561, 27989440, 28096518" /label="gdwB RNA" gene complement(3639954..3640056) /gene="gdwB" /locus_tag="BSU_misc_RNA_60" /label="gdwB gene" downshifts complement(3639980) /Source="Nicolas_upshifts" /id="D2015" /incds=0 /nref=194 /ntot=247 /MaxReadThrough="3.21415" /MaxDrop="5.58394" /score="-0.190335837" /energy="-10.7" /TU="U3062" /idTUdmin="U3065" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3640082..3640101) /Source="Nicolas_upshift_promotors" /id="U3062" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.483516483516484" /psig="0.999000999001" /xcortree=2404 /SigmaFactorBS="ccagcttatctgatgaaaactccgcaaataccCCTTGAAcca attcgaaccgTCCCTTATAATGCTAATATTggaaagtgaaaaggatatgataaaaaca g" /listShort="NA, yxkD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3640093) /Source="Nicolas_upshifts" /id="U3062" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.483516483516484" /psig="0.999000999001" /xcortree=2404 /SigmaFactorBS="ccagcttatctgatgaaaactccgcaaataccCCTTGAAcca attcgaaccgTCCCTTATAATGCTAATATTggaaagtgaaaaggatatgataaaaaca g" /listShort="NA, yxkD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3640095..3640836) /Source="Nicolas_S_feature" /locus_tag="new_3988981_3989722_c" /HighExp="S6, S8, S7, C30, S5, Gly, C90, Fru, BT, Pyr" /AntisenseName="yxkC" /AntisenseCor="-0.38162570069976298" /AntisenseRegPval="-10" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1491" promotor_-35 complement(3640115..3640121) /Source="Nicolas_upshift_promotors" /id="U3062" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.483516483516484" /psig="0.999000999001" /xcortree=2404 /SigmaFactorBS="ccagcttatctgatgaaaactccgcaaataccCCTTGAAcca attcgaaccgTCCCTTATAATGCTAATATTggaaagtgaaaaggatatgataaaaaca g" /listShort="NA, yxkD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3640173..3640180 /Source="Nicolas_upshift_promotors" /id="U3063" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2814 /SigmaFactorBS="cagataagctggaaaaaaatacgatttatctATTAAAAAaga acagatataACCGATAAGAAAAAAAGCAtatattttacaagcgaatgtaactataaat g" /listShort="S1492, yxkC, S1493" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3640193..3640211 /Source="Nicolas_upshift_promotors" /id="U3063" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2814 /SigmaFactorBS="cagataagctggaaaaaaatacgatttatctATTAAAAAaga acagatataACCGATAAGAAAAAAAGCAtatattttacaagcgaatgtaactataaat g" /listShort="S1492, yxkC, S1493" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3640202 /Source="Nicolas_upshifts" /id="U3063" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2814 /SigmaFactorBS="cagataagctggaaaaaaatacgatttatctATTAAAAAaga acagatataACCGATAAGAAAAAAAGCAtatattttacaagcgaatgtaactataaat g" /listShort="S1492, yxkC, S1493" /GFF_Attribute="listLong" /label="upshifts" S_feature 3640212..3640297 /Source="Nicolas_S_feature" /locus_tag="new_3989098_3989183" /HighExp="Cold, SMM, MG 150, GM 90, Glu, C30, GM 150, GM-0.2, GM 15, Fru" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1492" promotor_-35 3640273..3640280 /Source="Nicolas_upshift_promotors" /id="U3064" /multdbtbs="SigD" /comp="M17" /sig="SigA" /pcomp="0.731268731268731" /psig=1 /xcortree=2816 /SigmaFactorBS="aatgataataattataagaaattcataattttatATTGACTA agagaaataatatAGGCATTATAGTACATATGTttcgtacattttattacataggagg a" /listShort="yxkC, S1493" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3640294..3640313 /Source="Nicolas_upshift_promotors" /id="U3064" /multdbtbs="SigD" /comp="M17" /sig="SigA" /pcomp="0.731268731268731" /psig=1 /xcortree=2816 /SigmaFactorBS="aatgataataattataagaaattcataattttatATTGACTA agagaaataatatAGGCATTATAGTACATATGTttcgtacattttattacataggagg a" /listShort="yxkC, S1493" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3640299 /Source="Nicolas_upshifts" /id="U3064" /multdbtbs="SigD" /comp="M17" /sig="SigA" /pcomp="0.731268731268731" /psig=1 /xcortree=2816 /SigmaFactorBS="aatgataataattataagaaattcataattttatATTGACTA agagaaataatatAGGCATTATAGTACATATGTttcgtacattttattacataggagg a" /listShort="yxkC, S1493" /GFF_Attribute="listLong" /label="upshifts" CDS 3640445..3640987 /gene="yxkC" /locus_tag="BSU_38850" /old_locus_tag="BSU38850" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 12823818, 15033535" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391764.2" /db_xref="EnsemblGenomes-Gn:BSU38850" /db_xref="EnsemblGenomes-Tr:CAB15911" /db_xref="GOA:P94356" /db_xref="InterPro:IPR029050" /db_xref="InterPro:IPR029051" /db_xref="SubtiList:BG12541" /db_xref="UniProtKB/Swiss-Prot:P94356" /translation="MRHKIITFILAVVVIIIIGNMIGGGGGSEATSKTSSSSKAETEK TYNIGDTVKTEKTEVTVTKVEDRDTVGTQYVEKKASEGGTIVAVQYTIKNVSKKPISS FSIPTVKLVDADGTSYDSDIDASVNYATETKVDNSKILSDLNPNIKVTGVKAFEVDKE AYAKGTWKLKFSNDVIVKIK*" /label="yxkC CDS" gene 3640445..3640987 /gene="yxkC" /locus_tag="BSU_38850" /old_locus_tag="BSU38850" /label="yxkC gene" promotor_-10 complement(3640812..3640831) /Source="Nicolas_upshift_promotors" /id="U3065" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1368 /SigmaFactorBS="cctgttactttaatattaggatttagatcactcaaaatttta GAGTTATCAActtttgtctcagtTGCATAGTTTACAGAAGCATcaatatcagaatcat a" /listShort="S1491, NA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3640836) /Source="Nicolas_upshifts" /id="U3065" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1368 /SigmaFactorBS="cctgttactttaatattaggatttagatcactcaaaatttta GAGTTATCAActtttgtctcagtTGCATAGTTTACAGAAGCATcaatatcagaatcat a" /listShort="S1491, NA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3640845..3640854) /Source="Nicolas_upshift_promotors" /id="U3065" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1368 /SigmaFactorBS="cctgttactttaatattaggatttagatcactcaaaatttta GAGTTATCAActtttgtctcagtTGCATAGTTTACAGAAGCATcaatatcagaatcat a" /listShort="S1491, NA" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3640977 /Source="Nicolas_upshifts" /id="D2016" /incds=0 /nref=78 /ntot=276 /MaxReadThrough="4.33141" /MaxDrop="6.78221" /score="9.28209494" /energy="-14.4" /TU="U3063,U3064" /idTUdmin="U3064" /TUdmin="-181" /isTUend="FALSE" /label="downshifts" S_feature 3641022..3641344 /Source="Nicolas_S_feature" /locus_tag="new_3989908_3990230" /HighExp="Cold, C30, Heat, Fru, Glu, C90, BMM, Glucon, M/G, Mal" /AntisenseName="galE" /AntisenseCor="0.165797390333391" /AntisenseRegPval="-2.2000000000000002" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1493" CDS complement(3641062..3642081) /gene="galE" /locus_tag="BSU_38860" /old_locus_tag="BSU38860" /EC_number="5.1.3.7" /EC_number="5.1.3.2" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:1906927, 9555917, 14597172" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1906927, 9555917, 14597172; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="UDP-glucose 4-epimerase" /protein_id="NP_391765.1" /db_xref="EnsemblGenomes-Gn:BSU38860" /db_xref="EnsemblGenomes-Tr:CAB15912" /db_xref="GOA:P55180" /db_xref="InterPro:IPR005886" /db_xref="InterPro:IPR008089" /db_xref="InterPro:IPR016040" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11837" /db_xref="UniProtKB/Swiss-Prot:P55180" /translation="MAILVTGGAGYIGSHTCVELLNSGYEIVVLDNLSNSSAEALNRV KEITGKDLTFYEADLLDREAVDSVFAENEIEAVIHFAGLKAVGESVAIPLKYYHNNLT GTFILCEAMEKYGVKKIVFSSSATVYGVPETSPITEDFPLGATNPYGQTKLMLEQILR DLHTADNEWSVALLRYFNPFGAHPSGRIGEDPNGIPNNLMPYVAQVAVGKLEQLSVFG NDYPTKDGTGVRDYIHVVDLAEGHVKALEKVLNSTGADAYNLGTGTGYSVLEMVKAFE KVSGKEVPYRFADRRPGDIATCFADPAKAKRELGWEAKRGLEEMCADSWRWQSSNVNG YKSAE*" /label="galE CDS" gene complement(3641062..3642081) /gene="galE" /locus_tag="BSU_38860" /old_locus_tag="BSU38860" /label="galE gene" downshifts complement(3641080) /Source="Nicolas_upshifts" /id="D2017" /incds=0 /nref=235 /ntot=261 /MaxReadThrough="1.7919" /MaxDrop="7.32805" /score="24.6899971" /energy="-14.8" /TU="NA" /idTUdmin="U3066" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3642107..3642126) /Source="Nicolas_upshift_promotors" /id="U3066" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.794205794205794" /psig="0.988011988011988" /xcortree=2154 /SigmaFactorBS="aaaaactattaataaacgattaaacttcttaaaaatgGATGt ggaccggttctaaACACTATATAATGAAAACAGgtcattttttaggagggtttacatc a" /listShort="galE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3642121) /Source="Nicolas_upshifts" /id="U3066" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.794205794205794" /psig="0.988011988011988" /xcortree=2154 /SigmaFactorBS="aaaaactattaataaacgattaaacttcttaaaaatgGATGt ggaccggttctaaACACTATATAATGAAAACAGgtcattttttaggagggtttacatc a" /listShort="galE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3642141..3642144) /Source="Nicolas_upshift_promotors" /id="U3066" /multdbtbs="SigA" /comp="M7" /sig="SigA" /pcomp="0.794205794205794" /psig="0.988011988011988" /xcortree=2154 /SigmaFactorBS="aaaaactattaataaacgattaaacttcttaaaaatgGATGt ggaccggttctaaACACTATATAATGAAAACAGgtcattttttaggagggtttacatc a" /listShort="galE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3642196..3642702) /gene="yxkA" /locus_tag="BSU_38870" /old_locus_tag="BSU38870" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative phospholipid binding protein" /protein_id="NP_391766.1" /db_xref="EnsemblGenomes-Gn:BSU38870" /db_xref="EnsemblGenomes-Tr:CAB15913" /db_xref="InterPro:IPR005247" /db_xref="InterPro:IPR008914" /db_xref="InterPro:IPR036610" /db_xref="SubtiList:BG11899" /db_xref="UniProtKB/Swiss-Prot:P55185" /translation="MNIYVEANPYLHDKYSKYADEKYKREGNPFVSFPIHFDDIPSGA KTLALTFIDHDAIPVCGFSWIHWTAANIPAYIGELPEHASEERQDLMIQGQNSFASPL AGSNDPKVIHQYCGPTPPDKDHAYTLTVYALDAELNLQPGFYLNELYQEMKEHILAET SIELLARV*" /label="yxkA CDS" gene complement(3642196..3642702) /gene="yxkA" /locus_tag="BSU_38870" /old_locus_tag="BSU38870" /label="yxkA gene" promotor_-10 complement(3642708..3642727) /Source="Nicolas_upshift_promotors" /id="U3067" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=98 /SigmaFactorBS="acgtttacatgcgtatttgtttatcactgattatacatcgat tCGTTTAGtatacctatagaaCGAGAAAATAGAGAGAGGGAttcatatgaacatatac g" /listShort="yxkA, galE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3642730) /Source="Nicolas_upshifts" /id="U3067" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=98 /SigmaFactorBS="acgtttacatgcgtatttgtttatcactgattatacatcgat tCGTTTAGtatacctatagaaCGAGAAAATAGAGAGAGGGAttcatatgaacatatac g" /listShort="yxkA, galE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3642732..3642735 /Source="Nicolas_upshift_promotors" /id="U3068" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.854145854145854" /psig="0.998001998001998" /xcortree=1872 /SigmaFactorBS="atatgttcatatgaatccctctctctattttctcgttctATA GgtatactaaacgaaTCGATGTATAATCAGTGATAaacaaatacgcatgtaaacgtaa c" /listShort="yxjO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 complement(3642741..3642747) /Source="Nicolas_upshift_promotors" /id="U3067" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.971028971028971" /psig="0.971028971028971" /xcortree=98 /SigmaFactorBS="acgtttacatgcgtatttgtttatcactgattatacatcgat tCGTTTAGtatacctatagaaCGAGAAAATAGAGAGAGGGAttcatatgaacatatac g" /listShort="yxkA, galE" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3642750..3642769 /Source="Nicolas_upshift_promotors" /id="U3068" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.854145854145854" /psig="0.998001998001998" /xcortree=1872 /SigmaFactorBS="atatgttcatatgaatccctctctctattttctcgttctATA GgtatactaaacgaaTCGATGTATAATCAGTGATAaacaaatacgcatgtaaacgtaa c" /listShort="yxjO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3642753 /Source="Nicolas_upshifts" /id="U3068" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.854145854145854" /psig="0.998001998001998" /xcortree=1872 /SigmaFactorBS="atatgttcatatgaatccctctctctattttctcgttctATA GgtatactaaacgaaTCGATGTATAATCAGTGATAaacaaatacgcatgtaaacgtaa c" /listShort="yxjO" /GFF_Attribute="listLong" /label="upshifts" CDS 3642832..3643707 /gene="yxjO" /locus_tag="BSU_38880" /old_locus_tag="BSU38880" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12169591; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (LysR family)" /protein_id="NP_391767.1" /db_xref="EnsemblGenomes-Gn:BSU38880" /db_xref="EnsemblGenomes-Tr:CAB15914" /db_xref="GOA:P55181" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11898" /db_xref="UniProtKB/Swiss-Prot:P55181" /translation="MDLKWLQTFIAAAESESFREAAEHLYLTQPAVSQHMRKLEDELD MRLFLHSGRRVVLTDEGRLFLPYAKEMIHVYQAGKQKVSQWKQGYSRSLTLAVHPYIA SYILPRFLPAYIQKHPHVELSTHVAGSDAIKQAVEHNEADIGLSRKDPNTNTLYYQHI CEGTLCLAAPFQESRPDAASVLTRYRLLTHDHPSYGDAFLDNIRSHYPYLQMMAVGQT DTAVHMMKAGMGASFLPTYIIKQEEAEKKLMAVSTPAHLELPASQTFMMWKRNSEDIQ HFHAMLHDFMQREQV*" /label="yxjO CDS" gene 3642832..3643707 /gene="yxjO" /locus_tag="BSU_38880" /old_locus_tag="BSU38880" /label="yxjO gene" S_feature complement(3643082..3643170) /Source="Nicolas_S_feature" /locus_tag="new_3991968_3992056_c" /HighExp="GM 60, MG-0.1, MG 10, GM 5, S8, T0.30H, BC, S6, GM 15, GM 150" /AntisenseName="yxjO" /AntisenseCor="0.14032494397598999" /AntisenseRegPval="-1.7" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.0669" /TUlongSig="NA" /TUlongPSig="NA" /label="S1494" downshifts complement(3643104) /Source="Nicolas_upshifts" /id="D2018" /incds=1 /nref=22 /ntot=45 /MaxReadThrough="0.10815" /MaxDrop="6.05884" /score="5.06408541" /energy="-5.6" /TU="NA" /idTUdmin="U3069" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_no_box complement(3643130..3643230) /Source="Nicolas_upshift_promotors" /id="U3069" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.507492507492508" /psig="0.066933066933067" /xcortree=1478 /SigmaFactorBS="tttaatagcgtcagatccagccacatgagttgaaagctcgac atgcggatgtttttggatataggctggcagaaagcgaggcaagatataggacgcaatg t" /listShort="S1494" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(3643170) /Source="Nicolas_upshifts" /id="U3069" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.507492507492508" /psig="0.066933066933067" /xcortree=1478 /SigmaFactorBS="tttaatagcgtcagatccagccacatgagttgaaagctcgac atgcggatgtttttggatataggctggcagaaagcgaggcaagatataggacgcaatg t" /listShort="S1494" /GFF_Attribute="listLong" /label="upshifts" CDS 3643785..3644258 /gene="yxjN" /locus_tag="BSU_38890" /old_locus_tag="BSU38890" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein of unknown function" /protein_id="NP_391768.1" /db_xref="EnsemblGenomes-Gn:BSU38890" /db_xref="EnsemblGenomes-Tr:CAB15915" /db_xref="GOA:P55182" /db_xref="InterPro:IPR009916" /db_xref="InterPro:IPR020223" /db_xref="SubtiList:BG11897" /db_xref="UniProtKB/Swiss-Prot:P55182" /translation="MAMSPYIFIVLILIILSMYRERTVKPGKLLIIPLLLLWGVSASF QPAYFHSVLHVAISGILLLIGLACGFGIGKMVNVRIHPETGKVTSRGSLGSVILILVI LSLRMAARTWLPESNEMFIAIIHSMFFVPLGTITARNIMLYKAYRRLTAGKVSIQ*" /label="yxjN CDS" gene 3643785..3644258 /gene="yxjN" /locus_tag="BSU_38890" /old_locus_tag="BSU38890" /label="yxjN gene" CDS 3644276..3645496 /gene="yxjM" /locus_tag="BSU_38900" /old_locus_tag="BSU38900" /function="16.3: Control" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YxjL]" /protein_id="NP_391769.1" /db_xref="EnsemblGenomes-Gn:BSU38900" /db_xref="EnsemblGenomes-Tr:CAB15916" /db_xref="GOA:P55183" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR011712" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG11896" /db_xref="UniProtKB/Swiss-Prot:P55183" /translation="MNGQTPARHYYKKLVPSLILILNCIQFLSHPTKADPILLAFVFA VYLAFIWIIPYVASTAVSLSIFIGLWLLTDFFWAVSGQEQGAAYFLIVFLMIYAAFRL PSRLSLIFTACLIGGNILLLSSQGGSLNTIISNISIMLGLYVLFSSMRFRREARREAE RNHAELAKMHVQLEHAHKELQKAHAELQEASVLSLRYAVLEERTRIARDIHDSIGHEL TSVIVQLQSLPYILKSSKEDSEKVIQNVLSVARECLQEVRSVVHQMGRSESMVGLTAL RGLIHQVEERSGLHVSLDTAGLSEESWPPNVSETIYRILQEALTNIIRHADASHAAAV ISNDKSHLYVTITDDGQFTGSLTYGFGLTGMKERAEKAGGSLTFSAVQPSGLKIELSL PLMTTNKEQKDEQR*" /label="yxjM CDS" gene 3644276..3645496 /gene="yxjM" /locus_tag="BSU_38900" /old_locus_tag="BSU38900" /label="yxjM gene" CDS 3645483..3646139 /gene="yxjL" /locus_tag="BSU_38910" /old_locus_tag="BSU38910" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YxjM]" /protein_id="NP_391770.1" /db_xref="EnsemblGenomes-Gn:BSU38910" /db_xref="EnsemblGenomes-Tr:CAB15917" /db_xref="GOA:P55184" /db_xref="InterPro:IPR000792" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11895" /db_xref="UniProtKB/Swiss-Prot:P55184" /translation="MNKDKIRVALADDQPLVREGFRYVINAQTDMTVSGEAGDGHDII ALAKQTKPDVILMDVQMPRCSGIEAAKDIMSALPNTKIVILTTFDTEEYVFEGIRAGA VGYLLKDTLPEELIDAIRAAARGEAIFRTVTAAKIISETFRAKQQTHAEELAEPFTKR ELEVLQQMAYGLRNEDIAEKLFVSESTVKTHVHRILQKCNAQDRTQAVVFAIRNGIVQ *" /label="yxjL CDS" gene 3645483..3646139 /gene="yxjL" /locus_tag="BSU_38910" /old_locus_tag="BSU38910" /label="yxjL gene" promotor_-35 3646137..3646142 /Source="Nicolas_upshift_promotors" /id="U3070" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.863136863136863" /psig="0.998001998001998" /xcortree=2234 /SigmaFactorBS="aggcagtcgtttttgccattcgaaacggtattgtgcaaTAGA AAtctctcatcccgcCATGCTAAAATAAGACAAAGgagatgattggaaatgaaagaag a" /listShort="pepT" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3646156..3646175 /Source="Nicolas_upshift_promotors" /id="U3070" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.863136863136863" /psig="0.998001998001998" /xcortree=2234 /SigmaFactorBS="aggcagtcgtttttgccattcgaaacggtattgtgcaaTAGA AAtctctcatcccgcCATGCTAAAATAAGACAAAGgagatgattggaaatgaaagaag a" /listShort="pepT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3646159 /Source="Nicolas_upshifts" /id="U3070" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.863136863136863" /psig="0.998001998001998" /xcortree=2234 /SigmaFactorBS="aggcagtcgtttttgccattcgaaacggtattgtgcaaTAGA AAtctctcatcccgcCATGCTAAAATAAGACAAAGgagatgattggaaatgaaagaag a" /listShort="pepT" /GFF_Attribute="listLong" /label="upshifts" CDS 3646189..3647421 /gene="pepT" /locus_tag="BSU_38920" /old_locus_tag="BSU38920" /EC_number="3.4.11.4" /function="16.6: Maintain" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8978088, 10987140" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8978088, 10987140; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="peptidase T (tripeptidase)" /protein_id="NP_391771.1" /db_xref="EnsemblGenomes-Gn:BSU38920" /db_xref="EnsemblGenomes-Tr:CAB15918" /db_xref="GOA:P55179" /db_xref="InterPro:IPR001261" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR010161" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR036264" /db_xref="SubtiList:BG11842" /db_xref="UniProtKB/Swiss-Prot:P55179" /translation="MKEEIIERFTTYVKVDTQSDESVDTCPSTPGQLTLGNMLVDELK SIGMQDAAIDENGYVMATLPSNTEKDVPTIGFLAHVDTATDFTGKNVNPQIIESYDGK DIVLNEQLQVTLSPDQFPELSGYKGHTLITTDGTTLLGADNKAGIAEIMTAMDYLIKH PEIKHGTIRVAFTPDEEIGRGPHKFDVKRFNASFAYTVDGGPLGELEYESFNAAAAKI TIKGNNVHPGTAKGKMINSAKIAMKLNSLLPADEAPEYTEGYEGFYHLLSIQGDVEET KLHYIIRDFDKENFQNRKETMKRAVEELQNEYGQDRILLDMNDQYYNMREKIEPVIEI VNIAKQAMENLGIEPKISPIRGGTDGSQLSYMGLPTPNIFTGGENFHGKFEYISVDNM VKAVNVIVEIAKQFEAQA*" /label="pepT CDS" gene 3646189..3647421 /gene="pepT" /locus_tag="BSU_38920" /old_locus_tag="BSU38920" /label="pepT gene" downshifts complement(3646206) /Source="Nicolas_upshifts" /id="D2019" /incds=0 /nref=4 /ntot=116 /MaxReadThrough="0.86167" /MaxDrop="3.19485" /score="-2.15704435" /energy="-9.1" /TU="NA" /idTUdmin="U3069" /TUdmin="-3102" /isTUend="FALSE" /label="downshifts" downshifts 3647406 /Source="Nicolas_upshifts" /id="D2020" /incds=0 /nref=203 /ntot=244 /MaxReadThrough="3.3949" /MaxDrop="6.35116" /score="27.2051031" /energy="-13.5" /TU="U3070" /idTUdmin="U3070" /TUdmin="-22" /isTUend="TRUE" /label="downshifts" promotor_-35 3647467..3647476 /Source="Nicolas_upshift_promotors" /id="U3071" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1693 /SigmaFactorBS="ccagtccaaaaaaggactggcttttttgtgtgaaaaTGAAAC ATTTtaaacacgtcctCCGTAAAACAAGTATCaacaaatgaggaggaaaaacaatgac a" /listShort="S1495, S1496, S1497" /listLong="yxjJ, yxjI, NA, yxjH, NA, S1499, yxjG" /label="promotor_-35" promotor_-10 3647489..3647504 /Source="Nicolas_upshift_promotors" /id="U3071" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1693 /SigmaFactorBS="ccagtccaaaaaaggactggcttttttgtgtgaaaaTGAAAC ATTTtaaacacgtcctCCGTAAAACAAGTATCaacaaatgaggaggaaaaacaatgac a" /listShort="S1495, S1496, S1497" /listLong="yxjJ, yxjI, NA, yxjH, NA, S1499, yxjG" /label="promotor_-10" S_feature 3647491..3647713 /Source="Nicolas_S_feature" /locus_tag="new_3996377_3996599" /HighExp="T-0.40H, T0.30H, T0.0H, T-1.40H, T1.0H, T-1.10H, T3.30H, T2.0H, T1.30H, T3.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.80396299999999998" /TUshortSig="SigWXY" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1495" upshifts 3647491 /Source="Nicolas_upshifts" /id="U3071" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1693 /SigmaFactorBS="ccagtccaaaaaaggactggcttttttgtgtgaaaaTGAAAC ATTTtaaacacgtcctCCGTAAAACAAGTATCaacaaatgaggaggaaaaacaatgac a" /listShort="S1495, S1496, S1497" /listLong="yxjJ, yxjI, NA, yxjH, NA, S1499, yxjG" /label="upshifts" downshifts 3647670 /Source="Nicolas_upshifts" /id="D2021" /incds=0 /nref=162 /ntot=247 /MaxReadThrough="4.83682" /MaxDrop="4.66302" /score="-1.57383757" /energy="-6.2" /TU="U3071" /idTUdmin="U3070" /TUdmin=242 /isTUend="FALSE" /label="downshifts" promotor_-35 3647724..3647730 /Source="Nicolas_upshift_promotors" /id="U3072" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=236 /SigmaFactorBS="attcacccgtaccgcccaaatgctccgtaatttgggtttttT GTGTTCaattccgcaaaataGGGTATAAACCAAACAAGCaagaaaacagcacccaaaa a" /listShort="S1496, S1497, yxjJ, yxjI, NA" /listLong="yxjH, NA, S1499, yxjG" /label="promotor_-35" S_feature 3647743..3647843 /Source="Nicolas_S_feature" /locus_tag="new_3996629_3996729" /HighExp="Etha, Gly, Sw, Salt, B60, T0.30H, LoTm, M9-stat, T1.0H, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigB, SigWXY" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1496" upshifts 3647743 /Source="Nicolas_upshifts" /id="U3072" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=236 /SigmaFactorBS="attcacccgtaccgcccaaatgctccgtaatttgggtttttT GTGTTCaattccgcaaaataGGGTATAAACCAAACAAGCaagaaaacagcacccaaaa a" /listShort="S1496, S1497, yxjJ, yxjI, NA" /listLong="yxjH, NA, S1499, yxjG" /label="upshifts" promotor_-10 3647745..3647763 /Source="Nicolas_upshift_promotors" /id="U3072" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=236 /SigmaFactorBS="attcacccgtaccgcccaaatgctccgtaatttgggtttttT GTGTTCaattccgcaaaataGGGTATAAACCAAACAAGCaagaaaacagcacccaaaa a" /listShort="S1496, S1497, yxjJ, yxjI, NA" /listLong="yxjH, NA, S1499, yxjG" /label="promotor_-10" promotor_-35 3647822..3647829 /Source="Nicolas_upshift_promotors" /id="U3073" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2830 /SigmaFactorBS="aggtaattcgaattacgtaaacttaggttaaaagttaTATAA AGGaatttattttatcGTCGATAGTAACTATAGAAccaatcatcaacaagagcaaaca g" /listShort="S1497, yxjJ" /listLong="yxjI, NA, yxjH, NA, S1499, yxjG" /label="promotor_-35" promotor_-10 3647843..3647861 /Source="Nicolas_upshift_promotors" /id="U3073" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2830 /SigmaFactorBS="aggtaattcgaattacgtaaacttaggttaaaagttaTATAA AGGaatttattttatcGTCGATAGTAACTATAGAAccaatcatcaacaagagcaaaca g" /listShort="S1497, yxjJ" /listLong="yxjI, NA, yxjH, NA, S1499, yxjG" /label="promotor_-10" S_feature 3647845..3647942 /Source="Nicolas_S_feature" /locus_tag="new_3996731_3996828" /HighExp="Etha, T0.30H, Gly, T1.0H, Sw, Salt, T1.30H, GM 15, B60, GM-0.1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigD, SigB, SigWXY" /TUshortPSig="1, 1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1497" upshifts 3647845 /Source="Nicolas_upshifts" /id="U3073" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2830 /SigmaFactorBS="aggtaattcgaattacgtaaacttaggttaaaagttaTATAA AGGaatttattttatcGTCGATAGTAACTATAGAAccaatcatcaacaagagcaaaca g" /listShort="S1497, yxjJ" /listLong="yxjI, NA, yxjH, NA, S1499, yxjG" /label="upshifts" CDS 3647943..3648206 /gene="yxjJ" /locus_tag="BSU_38930" /old_locus_tag="BSU38930" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391772.1" /db_xref="EnsemblGenomes-Gn:BSU38930" /db_xref="EnsemblGenomes-Tr:CAB15919" /db_xref="GOA:P94353" /db_xref="SubtiList:BG12540" /db_xref="UniProtKB/Swiss-Prot:P94353" /translation="MLFIDLEFFEYFLAFYPYNREYQNFFWEVCNMILFIIIALCGYL LFSFSKDNRRKPQKTSPLPAAAPHHNNLIDLDAIRQKRRMHLS*" /label="yxjJ CDS" gene 3647943..3648206 /gene="yxjJ" /locus_tag="BSU_38930" /old_locus_tag="BSU38930" /label="yxjJ gene" promotor_-35 3647970..3647973 /Source="Nicolas_upshift_promotors" /id="U3074" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.541458541458541" /psig="0.554445554445554" /xcortree=653 /SigmaFactorBS="ttcttgttatttattgatttagaattttttGAATactttttg gcatttTATCCGTACAATAGAGAGTAccaaaactttttttgggaggtatgtaatatga t" /GFF_Attribute="listShort" /listLong="yxjI, NA, yxjH, NA, S1499, yxjG" /label="promotor_-35" promotor_-10 3647988..3648007 /Source="Nicolas_upshift_promotors" /id="U3074" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.541458541458541" /psig="0.554445554445554" /xcortree=653 /SigmaFactorBS="ttcttgttatttattgatttagaattttttGAATactttttg gcatttTATCCGTACAATAGAGAGTAccaaaactttttttgggaggtatgtaatatga t" /GFF_Attribute="listShort" /listLong="yxjI, NA, yxjH, NA, S1499, yxjG" /label="promotor_-10" upshifts 3648000 /Source="Nicolas_upshifts" /id="U3074" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.541458541458541" /psig="0.554445554445554" /xcortree=653 /SigmaFactorBS="ttcttgttatttattgatttagaattttttGAATactttttg gcatttTATCCGTACAATAGAGAGTAccaaaactttttttgggaggtatgtaatatga t" /GFF_Attribute="listShort" /listLong="yxjI, NA, yxjH, NA, S1499, yxjG" /label="upshifts" downshifts 3648154 /Source="Nicolas_upshifts" /id="D2022" /incds=0 /nref=4 /ntot=92 /MaxReadThrough="7.33654" /MaxDrop="3.1638" /score="-1.57383757" /energy="-6.2" /TU="U3072,U3073,U3074" /idTUdmin="U3073" /TUdmin="-110" /isTUend="FALSE" /label="downshifts" downshifts 3648198 /Source="Nicolas_upshifts" /id="D2023" /incds=0 /nref=44 /ntot=188 /MaxReadThrough="5.58502" /MaxDrop="4.5161" /score="-1.57383757" /energy="-6.2" /TU="U3072,U3073,U3074" /idTUdmin="U3073" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" promotor_-35 3648273..3648282 /Source="Nicolas_upshift_promotors" /id="U3075" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1670 /SigmaFactorBS="gctgctgaatcacgcagccttttaaaattgttttgatttaga gccTGAAACCTTTtcgccacctatCCGTAATTTCATACAAggcaaacccaaaggagac t" /listShort="yxjI, NA, yxjH, NA, S1499, yxjG" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3648288 /Source="Nicolas_upshifts" /id="U3075" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1670 /SigmaFactorBS="gctgctgaatcacgcagccttttaaaattgttttgatttaga gccTGAAACCTTTtcgccacctatCCGTAATTTCATACAAggcaaacccaaaggagac t" /listShort="yxjI, NA, yxjH, NA, S1499, yxjG" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3648294..3648309 /Source="Nicolas_upshift_promotors" /id="U3075" /multdbtbs="SigW" /comp="M9" /sig="SigWXY" /pcomp=1 /psig=1 /xcortree=1670 /SigmaFactorBS="gctgctgaatcacgcagccttttaaaattgttttgatttaga gccTGAAACCTTTtcgccacctatCCGTAATTTCATACAAggcaaacccaaaggagac t" /listShort="yxjI, NA, yxjH, NA, S1499, yxjG" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3648335..3648823 /gene="yxjI" /locus_tag="BSU_38940" /old_locus_tag="BSU38940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391773.1" /db_xref="EnsemblGenomes-Gn:BSU38940" /db_xref="EnsemblGenomes-Tr:CAB15920" /db_xref="InterPro:IPR007612" /db_xref="InterPro:IPR025659" /db_xref="SubtiList:BG12539" /db_xref="UniProtKB/Swiss-Prot:P94352" /translation="MIELFMKQKMFSFKDAFHIYDRDEQETFKVEGRFFSLGDSLQMT DSSGKTLVSIEQKLMSLLPRYEISIGGKTVCEVTKKVTFSKPKFVISGLNWEIDGDLW RDEFQLTDGENVRMSVSKKWLSWGDSYHLQIAYEEDVLICTAIAIVLDMVLYNDEDES IF*" /label="yxjI CDS" gene 3648335..3648823 /gene="yxjI" /locus_tag="BSU_38940" /old_locus_tag="BSU38940" /label="yxjI gene" promotor_-35 3648828..3648835 /Source="Nicolas_upshift_promotors" /id="U3076" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=2891 /SigmaFactorBS="cgatgaagatgaaagtattttctaaaaagCATTGACAattga tccaaaagTAATAATATTAAGATAATTGaaatctgaatatgaagttgtaccttatcaa g" /listShort="NA, yxjH, NA, S1499, yxjG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3648849..3648868 /Source="Nicolas_upshift_promotors" /id="U3076" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=2891 /SigmaFactorBS="cgatgaagatgaaagtattttctaaaaagCATTGACAattga tccaaaagTAATAATATTAAGATAATTGaaatctgaatatgaagttgtaccttatcaa g" /listShort="NA, yxjH, NA, S1499, yxjG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3648859 /Source="Nicolas_upshifts" /id="U3076" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=2891 /SigmaFactorBS="cgatgaagatgaaagtattttctaaaaagCATTGACAattga tccaaaagTAATAATATTAAGATAATTGaaatctgaatatgaagttgtaccttatcaa g" /listShort="NA, yxjH, NA, S1499, yxjG" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 3648889..3648995 /gene="mswI" /locus_tag="BSU_misc_RNA_61" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762; Product type n: RNA" /function="16.3: Control" /label="mswI RNA" gene 3648889..3648995 /gene="mswI" /locus_tag="BSU_misc_RNA_61" /label="mswI gene" downshifts 3648990 /Source="Nicolas_upshifts" /id="D2024" /incds=0 /nref=22 /ntot=102 /MaxReadThrough="7.18775" /MaxDrop="3.7896" /score="9.64734237" /energy="-14.5" /TU="U3075,U3076" /idTUdmin="U3072" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS 3649078..3650211 /gene="yxjH" /locus_tag="BSU_38950" /old_locus_tag="BSU38950" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12456320, 14563871, 17098890, 17114254; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative methyl-tetrahydrofolate methyltransferase (biofilm formation)" /protein_id="NP_391774.2" /db_xref="EnsemblGenomes-Gn:BSU38950" /db_xref="EnsemblGenomes-Tr:CAB15921" /db_xref="GOA:P42319" /db_xref="InterPro:IPR002629" /db_xref="SubtiList:BG11157" /db_xref="UniProtKB/Swiss-Prot:P42319" /translation="MAQQTNVAGQKTEKQRKAPFRADHVGSLLRSVPVKEARQKKAAG EMTAEQLRDIENQEITRIVEKQKEIGLDVVTDGEFRRSWWHYDFLEGLDGVEPFIPAE GIQFHNTKTKARSIKVTGKLDFTSHPALGDYQFLHEIAGNATPKLTIPSPNMLFFGEK ADKGIYDDQEEYFHDMAQAYKKAIKAFYDAGCRYLQLDDTSWSLFFEDKGREVVRALG GDPETLPAIFAKTINDAVADRPDDLTITMHICRGNFRSTWAASGGYDAVAETILDGLN LDGLFLEYDDDRSGNFDPLRFVKRKDLQIVLGLITSKYGELENPEDVKRRINEAARFV SLDQLCLSPQCGFASTEEGNLLTEEQQWAKLRHVIDIANDVWR*" /label="yxjH CDS" gene 3649078..3650211 /gene="yxjH" /locus_tag="BSU_38950" /old_locus_tag="BSU38950" /label="yxjH gene" S_feature complement(3649351..3649594) /Source="Nicolas_S_feature" /locus_tag="new_3998237_3998480_c" /HighExp="dia15, Diami, H2O2, dia5, C90, Paraq, Sw, BC, LBGstat, Lbtran" /AntisenseName="yxjH" /AntisenseCor="-0.34694665046491102" /AntisenseRegPval="-8.3000000000000007" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1498" promotor_-10 complement(3649589..3649608) /Source="Nicolas_upshift_promotors" /id="U3077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.982017982017982" /psig="0.997002997002997" /xcortree=2079 /SigmaFactorBS="taacggcagccagcatcatagaaggcttTGATTGCTtttttg tacgcttgGGCCATATCATGAAAGTATTcctcttgatcgtcataaatccctttatccg c" /listShort="S1498" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3649598) /Source="Nicolas_upshifts" /id="U3077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.982017982017982" /psig="0.997002997002997" /xcortree=2079 /SigmaFactorBS="taacggcagccagcatcatagaaggcttTGATTGCTtttttg tacgcttgGGCCATATCATGAAAGTATTcctcttgatcgtcataaatccctttatccg c" /listShort="S1498" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3649623..3649630) /Source="Nicolas_upshift_promotors" /id="U3077" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.982017982017982" /psig="0.997002997002997" /xcortree=2079 /SigmaFactorBS="taacggcagccagcatcatagaaggcttTGATTGCTtttttg tacgcttgGGCCATATCATGAAAGTATTcctcttgatcgtcataaatccctttatccg c" /listShort="S1498" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3650217..3650224 /Source="Nicolas_upshift_promotors" /id="U3078" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.97002997002997" /psig=1 /xcortree=2892 /SigmaFactorBS="gacattgccaacgatgtgtggagataatctatCATTGACAga aatagaaaatgtGTGAATAATAGATACTATCAgaaaatttaataaaaaggttttcctt a" /listShort="NA, S1499, yxjG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3650239..3650258 /Source="Nicolas_upshift_promotors" /id="U3078" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.97002997002997" /psig=1 /xcortree=2892 /SigmaFactorBS="gacattgccaacgatgtgtggagataatctatCATTGACAga aatagaaaatgtGTGAATAATAGATACTATCAgaaaatttaataaaaaggttttcctt a" /listShort="NA, S1499, yxjG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3650245 /Source="Nicolas_upshifts" /id="U3078" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.97002997002997" /psig=1 /xcortree=2892 /SigmaFactorBS="gacattgccaacgatgtgtggagataatctatCATTGACAga aatagaaaatgtGTGAATAATAGATACTATCAgaaaatttaataaaaaggttttcctt a" /listShort="NA, S1499, yxjG" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 3650280..3650386 /gene="mswJ" /locus_tag="BSU_misc_RNA_62" /product="S-adenosylmethionine riboswitch" /experiment="publication(s) with functional evidences, PMID:10094622, 12626738, 12910260, 17381305, 18039762" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10094622, 12626738, 12910260, 17381305, 18039762; Product type n: RNA" /function="16.3: Control" /label="mswJ RNA" gene 3650280..3650386 /gene="mswJ" /locus_tag="BSU_misc_RNA_62" /label="mswJ gene" downshifts 3650333 /Source="Nicolas_upshifts" /id="D2025" /incds=0 /nref=3 /ntot=21 /MaxReadThrough="8.35488" /MaxDrop="3.50346" /score="29.0146782" /energy="-14.5" /TU="U3075,U3076,U3078" /idTUdmin="U3075" /TUdmin="-1254" /isTUend="FALSE" /label="downshifts" S_feature 3650387..3650463 /Source="Nicolas_S_feature" /locus_tag="new_3999273_3999349" /HighExp="MG 5, MG t5, T1.0H, MG 10, T1.30H, BMM, T0.30H, T-0.40H, T0.0H, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigWXY" /TUshortPSig="1, 1, 1" /TUlongSig="SigA, SigD, SigB, SigWXY" /TUlongPSig="0.554, 1, 1, 1" /label="S1499" CDS 3650464..3651600 /gene="yxjG" /locus_tag="BSU_38960" /old_locus_tag="BSU38960" /function="16.11: Scavenge (Catabolism)" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12456320, 14563871, 17098890, 17114254, 21749987; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative methyltetrahydrofolate methyltransferase (biofilm formation)" /protein_id="NP_391775.3" /db_xref="EnsemblGenomes-Gn:BSU38960" /db_xref="EnsemblGenomes-Tr:CAB15922" /db_xref="GOA:P42318" /db_xref="InterPro:IPR002629" /db_xref="SubtiList:BG11156" /db_xref="UniProtKB/Swiss-Prot:P42318" /translation="MSQQTTPAEQKSLQRKKPPFRADQVGSLLRSEPVKKARLQKAAG EMTAEQLRQIENDEIIRIVEKQKETGLNVVTDGEFRRAWWHFDFLENLDGVEPFTPEQ GIQFHNVQTKARGIKVTGDIDFSTHPMLEDYSFLHSIAGDATPKMTIPSPNMLFFRGK LEKDEYKNDYQLFQHDVSKAYKKAIQAFYDRGCRYLQLDDTAWAVFLSEKGLKQIEAF GTTPDELRQLFAKSINDAIADRPDDLTVTMHICRGNFQSTWTAEGGYDAAAETIFDGL NLDGLFLEYDDSRSGGFEPLRYVKRSDLQLVLGLVTSKFGELENPDDVKRRIEEASRY VSLDQLCLSPQCGFASTEEGNKLTEEQQWAKLRHVVEIANDVWK*" /label="yxjG CDS" gene 3650464..3651600 /gene="yxjG" /locus_tag="BSU_38960" /old_locus_tag="BSU38960" /label="yxjG gene" downshifts 3651587 /Source="Nicolas_upshifts" /id="D2026" /incds=0 /nref=81 /ntot=187 /MaxReadThrough="4.24668" /MaxDrop="5.8124" /score="11.1243305" /energy="-12.8" /TU="U3076,U3078" /idTUdmin="U3075" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3651653..3652426) /gene="yxjF" /locus_tag="BSU_38970" /old_locus_tag="BSU38970" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydroxyacid dehydrogenase" /protein_id="NP_391776.2" /db_xref="EnsemblGenomes-Gn:BSU38970" /db_xref="EnsemblGenomes-Tr:CAB15923" /db_xref="GOA:P42317" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR011294" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11155" /db_xref="UniProtKB/Swiss-Prot:P42317" /translation="MRKQVALVTGAAGGIGFEIAREFAREGASVIVSDLRPEACEKAA SKLAEEGFDAAAIPYDVTKEAQVADTVNVIQKQYGRLDILVNNAGIQHVAPIEEFPTD TFEQLIKVMLTAPFIAMKHVFPIMKKQQFGRIINIASVNGLVGFAGKSAYNSAKHGVI GLTKVGALEGAPHGITVNALCPGYVDTQLVRNQLSDLSKTRNVPYDSVLEQVIFPLVP QKRLLSVKEIADYAVFLASEKAKGVTGQAVVLDGGYTAQ*" /label="yxjF CDS" gene complement(3651653..3652426) /gene="yxjF" /locus_tag="BSU_38970" /old_locus_tag="BSU38970" /label="yxjF gene" downshifts complement(3651663) /Source="Nicolas_upshifts" /id="D2027" /incds=0 /nref=23 /ntot=63 /MaxReadThrough="0.65" /MaxDrop="6.97604" /score="24.6585594" /energy="-12.8" /TU="NA" /idTUdmin="U3079" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3652443..3653093) /gene="scoB" /locus_tag="BSU_38980" /old_locus_tag="BSU38980" /EC_number="2.8.3.5" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17363272, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="acetoacetyl CoA-transferase (subunit B)" /protein_id="NP_391777.1" /db_xref="EnsemblGenomes-Gn:BSU38980" /db_xref="EnsemblGenomes-Tr:CAB15924" /db_xref="GOA:P42316" /db_xref="InterPro:IPR004164" /db_xref="InterPro:IPR004165" /db_xref="InterPro:IPR012791" /db_xref="PDB:3CDK" /db_xref="SubtiList:BG11154" /db_xref="UniProtKB/Swiss-Prot:P42316" /translation="MKEARKRMVKRAVQEIKDGMNVNLGIGMPTLVANEIPDGVHVML QSENGLLGIGPYPLEGTEDADLINAGKETITEVTGASYFDSAESFAMIRGGHIDLAIL GGMEVSEQGDLANWMIPGKMVKGMGGAMDLVNGAKRIVVIMEHVNKHGESKVKKTCSL PLTGQKVVHRLITDLAVFDFVNGRMTLTELQDGVTIEEVYEKTEADFAVSQSVLNS*" /label="scoB CDS" gene complement(3652443..3653093) /gene="scoB" /locus_tag="BSU_38980" /old_locus_tag="BSU38980" /label="scoB gene" CDS complement(3653090..3653806) /gene="scoA" /locus_tag="BSU_38990" /old_locus_tag="BSU38990" /EC_number="2.8.3.5" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 17363272; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="acetoacetyl CoA-transferase (subunit A)" /protein_id="NP_391778.1" /db_xref="EnsemblGenomes-Gn:BSU38990" /db_xref="EnsemblGenomes-Tr:CAB15925" /db_xref="GOA:P42315" /db_xref="InterPro:IPR004163" /db_xref="InterPro:IPR004165" /db_xref="InterPro:IPR012792" /db_xref="PDB:3CDK" /db_xref="SubtiList:BG11153" /db_xref="UniProtKB/Swiss-Prot:P42315" /translation="MGKVLSSSKEAAKLIHDGDTLIAGGFGLCGIPEQLILSIRDQGV KDLTVVSNNCGVDDWGLGLLLANKQIKKMIASYVGENKIFERQFLSGELEVELVPQGT LAERIRAGGAGIPGFYTATGVGTSIAEGKEHKTFGGRTYVLERGITGDVAIVKAWKAD TMGNLIFRKTARNFNPIAAMAGKITIAEAEEIVEAGELDPDHIHTPGIYVQHVVLGAS QEKRIEKRTVQQASGKGEAK*" /label="scoA CDS" gene complement(3653090..3653806) /gene="scoA" /locus_tag="BSU_38990" /old_locus_tag="BSU38990" /label="scoA gene" CDS complement(3653830..3655248) /gene="yxjC" /locus_tag="BSU_39000" /old_locus_tag="BSU39000" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative acid metabolite permease" /protein_id="NP_391779.3" /db_xref="EnsemblGenomes-Gn:BSU39000" /db_xref="EnsemblGenomes-Tr:CAB15926" /db_xref="GOA:P42314" /db_xref="SubtiList:BG11152" /db_xref="UniProtKB/Swiss-Prot:P42314" /translation="MELIIILLALGLLMFTAYRGFSVILFAPICALFAVLLTDPSHVL PFFSSIFMEKMAGFIKLYFPVFLLGAIFGKVVEMAGLAASIAKTIVRLVGAKRAILAI VLMGAVLTYSGVSLFVVVFAVYPFAKNMFQEANIPKRLIPGTIALGAFTFTMDALPGT PQIQNVIPTSFFKTDIYAAPWLGLMGAVIVLAAGMLYLESRRKKAQASGEGYGGFDSQ NAPAPESIESAAEPDKSPIRHALAFVPLILVGAVNKYFTIYLPKWYPNGFDFSSIGLK EFGRLDISSAAAIWSVEIALVIGIITTILFDWRSVFAQLKEGLNEGIGGALLASMNTG AEYGFGGIIAALPGFHKLSSGISHTFTDPLVNGAVTTTALAGITGSASGGMGIALSAM SEQYLQAIQAYNIPPEVMHRVISMASGGMDTLPHNGAVITLLAVTGLTHRQSYRDIFA ITLIKTAAVFAVIAIYSLTGLV*" /label="yxjC CDS" gene complement(3653830..3655248) /gene="yxjC" /locus_tag="BSU_39000" /old_locus_tag="BSU39000" /label="yxjC gene" promotor_-10 complement(3654416..3654434) /Source="Nicolas_upshift_promotors" /id="U3079" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=762 /SigmaFactorBS="gtgaataaatatttcaccatttacctgccaaagtggtatcCG AATGgatttgatttttcttCCATAGGATTAAAGGAGTTcggcaggcttgatatttctt c" /listShort="scoA, scoB, yxjF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3654435) /Source="Nicolas_upshifts" /id="U3079" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=762 /SigmaFactorBS="gtgaataaatatttcaccatttacctgccaaagtggtatcCG AATGgatttgatttttcttCCATAGGATTAAAGGAGTTcggcaggcttgatatttctt c" /listShort="scoA, scoB, yxjF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3654450..3654455) /Source="Nicolas_upshift_promotors" /id="U3079" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=762 /SigmaFactorBS="gtgaataaatatttcaccatttacctgccaaagtggtatcCG AATGgatttgatttttcttCCATAGGATTAAAGGAGTTcggcaggcttgatatttctt c" /listShort="scoA, scoB, yxjF" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3655249..3655333) /Source="Nicolas_S_feature" /locus_tag="new_4004135_4004219_c" /HighExp="S5, S4, S6, S3, S7, M9-stat, B60, S8, T4.0H, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.993" /TUlongSig="NA" /TUlongPSig="NA" /label="S1500" promotor_-10 complement(3655317..3655335) /Source="Nicolas_upshift_promotors" /id="U3080" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1046 /SigmaFactorBS="ggaaagctccgaaaaaaggagctttccttttttaatcGGAAT AgttggcccacgcttcTCGTACATATGGAAAGGGGacggaaacagccgatgcggacag g" /listShort="S1500, yxjC, scoA, scoB, yxjF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3655333) /Source="Nicolas_upshifts" /id="U3080" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1046 /SigmaFactorBS="ggaaagctccgaaaaaaggagctttccttttttaatcGGAAT AgttggcccacgcttcTCGTACATATGGAAAGGGGacggaaacagccgatgcggacag g" /listShort="S1500, yxjC, scoA, scoB, yxjF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3655351..3655356) /Source="Nicolas_upshift_promotors" /id="U3080" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.993006993006993" /psig="0.993006993006993" /xcortree=1046 /SigmaFactorBS="ggaaagctccgaaaaaaggagctttccttttttaatcGGAAT AgttggcccacgcttcTCGTACATATGGAAAGGGGacggaaacagccgatgcggacag g" /listShort="S1500, yxjC, scoA, scoB, yxjF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3655402..3656250) /gene="rlmA" /locus_tag="BSU_39010" /old_locus_tag="BSU39010" /EC_number="2.1.1.188" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 11967079, 14999102, 18406425, 23716046; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="23S rRNA m(1)G748 methyltransferase (class II)" /protein_id="NP_391780.1" /db_xref="EnsemblGenomes-Gn:BSU39010" /db_xref="EnsemblGenomes-Tr:CAB15927" /db_xref="GOA:P42313" /db_xref="InterPro:IPR013216" /db_xref="InterPro:IPR016718" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11151" /db_xref="UniProtKB/Swiss-Prot:P42313" /translation="MKRTVDFSMFRCPLCDSSMDAASGKSLICTERGHTFDLSRHGYV NFLTKPVKTSYGAELFEARSRLIGECGFFDPLHDAIAELISHPKSGHEAFTILDSGCG EGSHLNALCGFDYAGKAAIGTGIDLSKDGILKASKAFKDLMWAVADVARAPFHDRQFD VVLSIFSPSNYAEFHRLLKNDGMLIKVVPRSDYLIELRQFLYTDSPRRTYSNTAAVER FTANAAHSRPVRLRYVKTLDQQAIHWLLKMTPLAWSAPKDRVSLLKEMKSADITVDVD ILIGMK*" /label="rlmA CDS" gene complement(3655402..3656250) /gene="rlmA" /locus_tag="BSU_39010" /old_locus_tag="BSU39010" /label="rlmA gene" downshifts complement(3655412) /Source="Nicolas_upshifts" /id="D2028" /incds=0 /nref=54 /ntot=218 /MaxReadThrough="1.618" /MaxDrop="4.63737" /score="17.0758624" /energy="-15.1" /TU="NA" /idTUdmin="U3081" /TUdmin="-9" /isTUend="TRUE" /label="downshifts" S_feature complement(3656251..3656436) /Source="Nicolas_S_feature" /locus_tag="new_4005137_4005322_c" /HighExp="B60, LBGstat, LPhT, M9-stat, C30, T0.30H, HPh, Oxctl, Heat, LBGtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigD" /TUshortPSig="1, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1501" promotor_-10 complement(3656425..3656444) /Source="Nicolas_upshift_promotors" /id="U3081" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=2742 /SigmaFactorBS="agcatgtcagtactgatttttcttcactataaGGTTCcagct cctggatattTGTTGTATGATGGAAACGGGgaaacccatacagcagaaagggagtttt t" /listShort="S1501, yxjB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3656436) /Source="Nicolas_upshifts" /id="U3081" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=2742 /SigmaFactorBS="agcatgtcagtactgatttttcttcactataaGGTTCcagct cctggatattTGTTGTATGATGGAAACGGGgaaacccatacagcagaaagggagtttt t" /listShort="S1501, yxjB" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3656438..3657163) /Source="Nicolas_S_feature" /locus_tag="new_4005324_4006049_c" /HighExp="LBGstat, C30, GM 25, Heat, GM 10, GM 45, GM 60, GM 90, T0.30H, GM 120" /AntisenseName="NA" /AntisenseCor="0.20859849915331599" /AntisenseRegPval="-3.2" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1502" promotor_-35 complement(3656460..3656464) /Source="Nicolas_upshift_promotors" /id="U3081" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.927072927072927" /psig=1 /xcortree=2742 /SigmaFactorBS="agcatgtcagtactgatttttcttcactataaGGTTCcagct cctggatattTGTTGTATGATGGAAACGGGgaaacccatacagcagaaagggagtttt t" /listShort="S1501, yxjB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3656598..3656605 /Source="Nicolas_upshift_promotors" /id="U3082" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.478521478521479" /psig="0.996003996003996" /xcortree=2667 /SigmaFactorBS="taaattttattattgtgaaaatagttaaaaaGGTTGATTttc aaaaagtgaAAGGATAAAATACTGCTATCatcttagaaaaagacattcttgtatatga t" /listShort="NA, S1503, yxjA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3656618..3656637 /Source="Nicolas_upshift_promotors" /id="U3082" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.478521478521479" /psig="0.996003996003996" /xcortree=2667 /SigmaFactorBS="taaattttattattgtgaaaatagttaaaaaGGTTGATTttc aaaaagtgaAAGGATAAAATACTGCTATCatcttagaaaaagacattcttgtatatga t" /listShort="NA, S1503, yxjA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3656627 /Source="Nicolas_upshifts" /id="U3082" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.478521478521479" /psig="0.996003996003996" /xcortree=2667 /SigmaFactorBS="taaattttattattgtgaaaatagttaaaaaGGTTGATTttc aaaaagtgaAAGGATAAAATACTGCTATCatcttagaaaaagacattcttgtatatga t" /listShort="NA, S1503, yxjA" /GFF_Attribute="listLong" /label="upshifts" misc_RNA 3656637..3656739 /gene="gswB" /locus_tag="BSU_misc_RNA_63" /product="guanine riboswitch" /experiment="publication(s) with functional evidences, PMID:12787499, 15549109, 18072940, 19603494, 20022916, 20200045, 20204714, 21439477" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12787499, 15549109, 18072940, 19603494, 20022916, 20200045, 20204714, 21439477; Product type n: RNA" /label="gswB RNA" gene 3656637..3656739 /gene="gswB" /locus_tag="BSU_misc_RNA_63" /label="gswB gene" S_feature 3656740..3656843 /Source="Nicolas_S_feature" /locus_tag="new_4005626_4005729" /HighExp="C90, G180, M40t45, dia15, LBGexp, Lbexp, Lbtran, G135, Mt0, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1503" promotor_-35 3656815..3656821 /Source="Nicolas_upshift_promotors" /id="U3083" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=809 /SigmaFactorBS="tcacactttctgcacttccagaatttgtgaAGGATAAgagct ttttttgtTTCCATAATAACcctcataggagttgctatcatgtactttttactaaacc t" /listShort="yxjA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3656835..3656846 /Source="Nicolas_upshift_promotors" /id="U3083" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=809 /SigmaFactorBS="tcacactttctgcacttccagaatttgtgaAGGATAAgagct ttttttgtTTCCATAATAACcctcataggagttgctatcatgtactttttactaaacc t" /listShort="yxjA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3656845 /Source="Nicolas_upshifts" /id="U3083" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp=1 /psig=1 /xcortree=809 /SigmaFactorBS="tcacactttctgcacttccagaatttgtgaAGGATAAgagct ttttttgtTTCCATAATAACcctcataggagttgctatcatgtactttttactaaacc t" /listShort="yxjA" /GFF_Attribute="listLong" /label="upshifts" CDS 3656866..3658059 /gene="nupG" /locus_tag="BSU_39020" /old_locus_tag="BSU39020" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 12787499, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="purine nucleoside transporter" /protein_id="NP_391781.2" /db_xref="EnsemblGenomes-Gn:BSU39020" /db_xref="EnsemblGenomes-Tr:CAB15928" /db_xref="GOA:P42312" /db_xref="InterPro:IPR002668" /db_xref="InterPro:IPR008276" /db_xref="InterPro:IPR011657" /db_xref="InterPro:IPR018270" /db_xref="SubtiList:BG11150" /db_xref="UniProtKB/Swiss-Prot:P42312" /translation="MYFLLNLVGLIVIMAVVFLCSPQKKKIKWRPIITLIVLELLITW FMLGTKVGSWAIGKIGDFFTWLIACASDGIAFAFPSVMANETVDFFFSALLPIIFIVT FFDILTYFGILPWLIDKIGWVISKASRLPKLESFFSIQMMFLGNTEALAVIRQQLTVL SNNRLLTFGLMSMSSISGSIIGSYLSMVPATYVFTAIPLNCLNALIIANLLNPVHVPE DEDIIYTPPKEEKKDFFSTISNSMLVGMNMVIVILAMVIGYVALTSAVNGILGVFVHG LTIQTIFAYLFSPFAFLLGLPVHDAMYVAQLMGMKLATNEFVAMLDLKNNLKSLPPHT VAVATTFLTSFANFSTVGMIYGTYNSILDGEKSTVIGRNVWKLLVSGIAVSLLSAAIV GLFVW*" /label="nupG CDS" gene 3656866..3658059 /gene="nupG" /locus_tag="BSU_39020" /old_locus_tag="BSU39020" /label="nupG gene" promotor_-10 complement(3657150..3657168) /Source="Nicolas_upshift_promotors" /id="U3084" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2848 /SigmaFactorBS="cgattttatcaatcagccaaggcaaaatgccgaaatacGTTA AAATatcaaagaatgtGACGATAAAGATAATTGGAagaagcgcactaaagaaaaagtc t" /listShort="S1502, S1501, yxjB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3657166) /Source="Nicolas_upshifts" /id="U3084" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2848 /SigmaFactorBS="cgattttatcaatcagccaaggcaaaatgccgaaatacGTTA AAATatcaaagaatgtGACGATAAAGATAATTGGAagaagcgcactaaagaaaaagtc t" /listShort="S1502, S1501, yxjB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3657181..3657188) /Source="Nicolas_upshift_promotors" /id="U3084" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=2848 /SigmaFactorBS="cgattttatcaatcagccaaggcaaaatgccgaaatacGTTA AAATatcaaagaatgtGACGATAAAGATAATTGGAagaagcgcactaaagaaaaagtc t" /listShort="S1502, S1501, yxjB" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3657835 /Source="Nicolas_upshifts" /id="D2029" /incds=1 /nref=1 /ntot=58 /MaxReadThrough="5.88279" /MaxDrop="2.4159" /score="8.04757856" /energy="-16.6" /TU="U3082,U3083" /idTUdmin="U3082" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" downshifts 3658055 /Source="Nicolas_upshifts" /id="D2030" /incds=0 /nref=71 /ntot=204 /MaxReadThrough="2.7474" /MaxDrop="4.05925" /score="8.04757856" /energy="-16.6" /TU="NA" /idTUdmin="U3082" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3658101..3658529) /gene="yxiTc" /locus_tag="BSU_39029" /old_locus_tag="BSU39029" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (C-terminus)" /translation="KTKKQANSRALKREYQTSFSVKYNAAGKLSIQTLNYIYSGGAHG LTSVQSFNYDLKAQKRVTLDQILNTKTKVSKTRDYLYSYIKKHDVLFFSDVKKEDITL NRDTMFYFTANGIAIVFGQYDLGPYAAGIRDVQVPASIYQ*" /label="yxiTc CDS" gene complement(3658101..3658529) /gene="yxiTc" /locus_tag="BSU_39029" /old_locus_tag="BSU39029" /pseudo /label="yxiTc gene" CDS complement(3658530..3658772) /gene="yxiTn" /locus_tag="BSU_39030" /old_locus_tag="BSU39030" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /pseudo /codon_start=1 /transl_table=11 /product="conserved protein of unknown function (N-terminus)" /db_xref="PSEUDO:CAB15929.2" /db_xref="SubtiList:BG11149" /db_xref="UniProtKB/Swiss-Prot:P42311" /translation="MKWNNMLKAAGIAVLLFSVFAYAAPSLKAVQAKTPTVSTHTYKK IKELTYPQVHHVGNAAFEKKINQELKAYMNNRIRNT*" /label="yxiTn CDS" gene complement(3658530..3658772) /gene="yxiTn" /locus_tag="BSU_39030" /old_locus_tag="BSU39030" /pseudo /label="yxiTn gene" S_feature complement(3658773..3658836) /Source="Nicolas_S_feature" /locus_tag="new_4007659_4007722_c" /HighExp="T2.30H, S6, Etha, T3.30H, S5, BT, T3.0H, T4.0H, T2.0H, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigWXY" /TUshortPSig="0.942" /TUlongSig="NA" /TUlongPSig="NA" /label="S1504" promotor_-10 complement(3658825..3658840) /Source="Nicolas_upshift_promotors" /id="U3085" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.942057942057942" /psig="0.942057942057942" /xcortree=757 /SigmaFactorBS="tctttttttattggaaaaatcatgctgttagacctAGAAACT TCTttcgatttaatCAGTCTATAAAAGTGTgtattgcttaaataagggaatgataaac a" /listShort="S1504, yxiT, yxiT" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3658836) /Source="Nicolas_upshifts" /id="U3085" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.942057942057942" /psig="0.942057942057942" /xcortree=757 /SigmaFactorBS="tctttttttattggaaaaatcatgctgttagacctAGAAACT TCTttcgatttaatCAGTCTATAAAAGTGTgtattgcttaaataagggaatgataaac a" /listShort="S1504, yxiT, yxiT" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3658852..3658861) /Source="Nicolas_upshift_promotors" /id="U3085" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.942057942057942" /psig="0.942057942057942" /xcortree=757 /SigmaFactorBS="tctttttttattggaaaaatcatgctgttagacctAGAAACT TCTttcgatttaatCAGTCTATAAAAGTGTgtattgcttaaataagggaatgataaac a" /listShort="S1504, yxiT, yxiT" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3658869 /Source="Nicolas_upshifts" /id="D2031" /incds=0 /nref=10 /ntot=69 /MaxReadThrough="0.814549999999999" /MaxDrop="3.89525" /score="14.5338714" /energy="-6.9" /TU="NA" /idTUdmin="U3082" /TUdmin=814 /isTUend="FALSE" /label="downshifts" CDS complement(3658917..3659207) /gene="yxiS" /locus_tag="BSU_39040" /old_locus_tag="BSU39040" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391783.2" /db_xref="EnsemblGenomes-Gn:BSU39040" /db_xref="EnsemblGenomes-Tr:CAB15930" /db_xref="SubtiList:BG11148" /db_xref="UniProtKB/Swiss-Prot:P42310" /translation="MNEKQLTEAYERDENMMILVFAQWCVNHDLDPMELYAKAYPQQK LNESLKKTMDDLVVPKHEAEHIPDQTVIAVLEMFGNTDLAQALHEAISGRKQ*" /label="yxiS CDS" gene complement(3658917..3659207) /gene="yxiS" /locus_tag="BSU_39040" /old_locus_tag="BSU39040" /label="yxiS gene" downshifts complement(3658923) /Source="Nicolas_upshifts" /id="D2032" /incds=0 /nref=168 /ntot=241 /MaxReadThrough="3.10756" /MaxDrop="6.10709" /score="16.5130207" /energy="-6.9" /TU="NA" /idTUdmin="U3086" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3659232..3659251) /Source="Nicolas_upshift_promotors" /id="U3086" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96103896103896" /psig="0.995004995004995" /xcortree=1926 /SigmaFactorBS="aggcatttatcgatgcggttgctgctcatcgccattgGGATA GACgaatttgatcggcTCCTGTATCTTTAAGGAAGAtacttttcataaggagcatgac a" /listShort="yxiS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3659249) /Source="Nicolas_upshifts" /id="U3086" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96103896103896" /psig="0.995004995004995" /xcortree=1926 /SigmaFactorBS="aggcatttatcgatgcggttgctgctcatcgccattgGGATA GACgaatttgatcggcTCCTGTATCTTTAAGGAAGAtacttttcataaggagcatgac a" /listShort="yxiS" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3659257..3661317) /gene="katE" /locus_tag="BSU_39050" /old_locus_tag="BSU39050" /EC_number="1.11.1.6" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:7559348, 8931328, 16151211" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7559348, 8931328, 16151211; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="catalase 2" /protein_id="NP_391784.2" /db_xref="EnsemblGenomes-Gn:BSU39050" /db_xref="EnsemblGenomes-Tr:CAB15931" /db_xref="GOA:P42234" /db_xref="InterPro:IPR002226" /db_xref="InterPro:IPR002818" /db_xref="InterPro:IPR010582" /db_xref="InterPro:IPR011614" /db_xref="InterPro:IPR018028" /db_xref="InterPro:IPR020835" /db_xref="InterPro:IPR024708" /db_xref="InterPro:IPR024712" /db_xref="InterPro:IPR029062" /db_xref="InterPro:IPR037060" /db_xref="SubtiList:BG11102" /db_xref="UniProtKB/Swiss-Prot:P42234" /translation="MSDDQNKRVNEHSKDEQLEQYRTDNSGKKMTTNQGLRVSEDEHS LKAGVRGPTLMEDFHFREKMTHFDHERIPERVVHARGFGVHGFFQVYEPMTEYTRAKF LQDPSVKTPVFVRFSTVAGSKGSADTVRDARGFATKFYTEEGNYDLVGNNIPVFFIQD AIKFPDLVHAFKPEPHNEMPQAATAHDTFWDFVANNPESAHMVMWTMSDRGIPRSYRM MEGFGVHTFRFVNEQGKARFVKFHWKPVLGVHSLVWDEAQKIAGKDPDFHRRDLWETI ENGGKVEYELGVQMIDEEDEFKFDFDILDPTKLWPEELVPVKIIGKMTLNRNQDNVFA ETEQVAFHPGNVVPGIDFTNDPLLQGRLFSYTDTQLIRLGGPNFHEIPINRPVCPFHN NQYDGYHRMTINKGPVAYHKNSLQNNDPSPATAEEGGYVHYQEKVEGKKIRQRSDSFN DYYSQAKLFWNSMSPVEKQHIISAFCFEVGKVKSKDVQRQVVDVFSNVDADLAEEIAK GVGVAAPAKRKASKEILTSPALSQARTVKTASTRKVAVLAGNGFHEKELQTVLEALKQ EGITVDIISQNLGYMTSGSGQQLEASGTFLTVDSVLYDAVYAAGGLELKDNKQAMAFI REAYNHYKAIGAANEGIDLLQSSVGTTEGLGIVTAKDEPDYTAFSKAFIDAVAAHRHW DRRI*" /label="katE CDS" gene complement(3659257..3661317) /gene="katE" /locus_tag="BSU_39050" /old_locus_tag="BSU39050" /label="katE gene" promotor_-35 complement(3659265..3659272) /Source="Nicolas_upshift_promotors" /id="U3086" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.96103896103896" /psig="0.995004995004995" /xcortree=1926 /SigmaFactorBS="aggcatttatcgatgcggttgctgctcatcgccattgGGATA GACgaatttgatcggcTCCTGTATCTTTAAGGAAGAtacttttcataaggagcatgac a" /listShort="yxiS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3661346..3661364) /Source="Nicolas_upshift_promotors" /id="U3087" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=220 /SigmaFactorBS="caaaaatcctaatgagcggattagcAGTTTATatgaagaacg ccacGGGTAAATGTGCTGTAGAAtgtttcgttttaaaaagggggagcagacatgagtg a" /listShort="katE, yxiS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3661350) /Source="Nicolas_upshifts" /id="U3087" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=220 /SigmaFactorBS="caaaaatcctaatgagcggattagcAGTTTATatgaagaacg ccacGGGTAAATGTGCTGTAGAAtgtttcgttttaaaaagggggagcagacatgagtg a" /listShort="katE, yxiS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3661379..3661385) /Source="Nicolas_upshift_promotors" /id="U3087" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=220 /SigmaFactorBS="caaaaatcctaatgagcggattagcAGTTTATatgaagaacg ccacGGGTAAATGTGCTGTAGAAtgtttcgttttaaaaagggggagcagacatgagtg a" /listShort="katE, yxiS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3661410..3661415 /Source="Nicolas_upshift_promotors" /id="U3088" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1049 /SigmaFactorBS="cgttcttcatataaactgctaatccgctcattaggatttttG GTCTAcatataaatatgcggTCATACACATTTGAAATAAgccttcttcacagaaagaa a" /listShort="S1505, citH, S1506" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3661429 /Source="Nicolas_upshifts" /id="U3088" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1049 /SigmaFactorBS="cgttcttcatataaactgctaatccgctcattaggatttttG GTCTAcatataaatatgcggTCATACACATTTGAAATAAgccttcttcacagaaagaa a" /listShort="S1505, citH, S1506" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3661431..3661449 /Source="Nicolas_upshift_promotors" /id="U3088" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1049 /SigmaFactorBS="cgttcttcatataaactgctaatccgctcattaggatttttG GTCTAcatataaatatgcggTCATACACATTTGAAATAAgccttcttcacagaaagaa a" /listShort="S1505, citH, S1506" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3661443..3661517 /Source="Nicolas_S_feature" /locus_tag="new_4010329_4010403" /HighExp="S6, S5, S4, S8, S7, S3, M9-stat, LoTm, BT, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1505" CDS 3661518..3662798 /gene="citH" /locus_tag="BSU_39060" /old_locus_tag="BSU39060" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8892821, 11053381, 15849754, 16850406, 18556792" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8892821, 11053381, 15849754, 16850406, 18556792; Product type t : transporter" /codon_start=1 /transl_table=11 /product="secondary transporter of divalent metal ions/citrate complexes" /protein_id="NP_391785.2" /db_xref="EnsemblGenomes-Gn:BSU39060" /db_xref="EnsemblGenomes-Tr:CAB15932" /db_xref="GOA:P42308" /db_xref="InterPro:IPR004680" /db_xref="InterPro:IPR014738" /db_xref="SubtiList:BG11146" /db_xref="UniProtKB/Swiss-Prot:P42308" /translation="MLAILGFVMMIVFMYLIMSNRLSALIALIVVPIVFALISGFGKD LGEMMIQGVTDLAPTGIMLLFAILYFGIMIDSGLFDPLIAKILSFVKGDPLKIAVGTA VLTMTISLDGDGTTTYMITIAAMLPLYKRLGMNRLVLAGIAMLGSGVMNIIPWGGPTA RVLASLKLDTSEVFTPLIPAMIAGILWVIAVAYILGKKERKRLGVISIDHAPSSDPEA APLKRPALQWFNLLLTVALMAALITSLLPLPVLFMTAFAVALMVNYPNVKEQQKRISA HAGNALNVVSMVFAAGIFTGILSGTKMVDAMAHSLVSLIPDAMGPHLPLITAIVSMPF TFFMSNDAFYFGVLPIIAEAASAYGIDAAEIGRASLLGQPVHLLSPLVPSTYLLVGMA GVSFGDHQKFTIKWAVGTTIVMTIAALLIGIISF*" /label="citH CDS" gene 3661518..3662798 /gene="citH" /locus_tag="BSU_39060" /old_locus_tag="BSU39060" /label="citH gene" S_feature 3662799..3662938 /Source="Nicolas_S_feature" /locus_tag="new_4011685_4011824" /HighExp="S6, S5, S4, S8, S7, S3, M9-stat, BT, T5.0H, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.382965" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1506" downshifts 3662895 /Source="Nicolas_upshifts" /id="D2033" /incds=0 /nref=3 /ntot=26 /MaxReadThrough="2.69139" /MaxDrop="3.50434" /score="10.8797157" /energy="-9" /TU="NA" /idTUdmin="U3088" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3662956..3663684) /gene="bglS" /locus_tag="BSU_39070" /old_locus_tag="BSU39070" /EC_number="3.2.1.73" /EC_number="3.2.1.6" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1369198, 3106158, 7704256, 20600285, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1369198, 3106158, 7704256, 20600285, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="endo-beta-1,3-1,4 glucanase" /protein_id="NP_391786.1" /db_xref="EnsemblGenomes-Gn:BSU39070" /db_xref="EnsemblGenomes-Tr:CAB15943" /db_xref="GOA:P04957" /db_xref="InterPro:IPR000757" /db_xref="InterPro:IPR008263" /db_xref="InterPro:IPR008264" /db_xref="InterPro:IPR013320" /db_xref="PDB:3O5S" /db_xref="SubtiList:BG10476" /db_xref="UniProtKB/Swiss-Prot:P04957" /translation="MPYLKRVLLLLVTGLFMSLFAVTATASAQTGGSFFDPFNGYNSG FWQKADGYSNGNMFNCTWRANNVSMTSLGEMRLALTSPAYNKFDCGENRSVQTYGYGL YEVRMKPAKNTGIVSSFFTYTGPTDGTPWDEIDIEFLGKDTTKVQFNYYTNGAGNHEK IVDLGFDAANAYHTYAFDWQPNSIKWYVDGQLKHTATNQIPTTPGKIMMNLWNGTGVD EWLGSYNGVNPLYAHYDWVRYTKK*" /label="bglS CDS" gene complement(3662956..3663684) /gene="bglS" /locus_tag="BSU_39070" /old_locus_tag="BSU39070" /label="bglS gene" downshifts complement(3662973) /Source="Nicolas_upshifts" /id="D2034" /incds=0 /nref=64 /ntot=139 /MaxReadThrough="1.52649" /MaxDrop="6.38109" /score="-8.35070051" /energy="-16.3" /TU="NA" /idTUdmin="U3089" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3663715..3663734) /Source="Nicolas_upshift_promotors" /id="U3089" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.621378621378621" /psig=1 /xcortree=366 /SigmaFactorBS="tagtaagattcgatattatcattattttgacCGATGTTCcct tttaaaagaaTCATGTAAGATCAACATAGAaaacgctttcaatgaaaggggaatgcca a" /listShort="bglS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3663726) /Source="Nicolas_upshifts" /id="U3089" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.621378621378621" /psig=1 /xcortree=366 /SigmaFactorBS="tagtaagattcgatattatcattattttgacCGATGTTCcct tttaaaagaaTCATGTAAGATCAACATAGAaaacgctttcaatgaaaggggaatgcca a" /listShort="bglS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3663748..3663755) /Source="Nicolas_upshift_promotors" /id="U3089" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.621378621378621" /psig=1 /xcortree=366 /SigmaFactorBS="tagtaagattcgatattatcattattttgacCGATGTTCcct tttaaaagaaTCATGTAAGATCAACATAGAaaacgctttcaatgaaaggggaatgcca a" /listShort="bglS" /GFF_Attribute="listLong" /label="promotor_-35" S_feature complement(3663872..3663979) /Source="Nicolas_S_feature" /locus_tag="new_4012758_4012865_c" /HighExp="Sw, LPhT, T0.30H, M0t90, M9-stat, M40t90, Lbtran, Lbstat, S2, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1507" downshifts complement(3663915) /Source="Nicolas_upshifts" /id="D2035" /incds=0 /nref=21 /ntot=184 /MaxReadThrough="3.35114" /MaxDrop="4.38508" /score="-8.35070051" /energy="-16.3" /TU="U3090,U3091" /idTUdmin="U3091" /TUdmin="-174" /isTUend="FALSE" /label="downshifts" CDS complement(3663980..3664813) /gene="licT" /locus_tag="BSU_39080" /old_locus_tag="BSU39080" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11447120, 11580842, 11733988, 12169607, 15699035, 21278164, 23475962, 28235843" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11447120, 11580842, 11733988, 12169607, 15699035, 21278164, 23475962, 28235843; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional antiterminator (BglG family)" /protein_id="NP_391787.2" /db_xref="EnsemblGenomes-Gn:BSU39080" /db_xref="EnsemblGenomes-Tr:CAB15944" /db_xref="GOA:P39805" /db_xref="InterPro:IPR001550" /db_xref="InterPro:IPR004341" /db_xref="InterPro:IPR011608" /db_xref="InterPro:IPR036634" /db_xref="InterPro:IPR036650" /db_xref="PDB:1H99" /db_xref="PDB:1L1C" /db_xref="PDB:1TLV" /db_xref="SubtiList:BG10474" /db_xref="UniProtKB/Swiss-Prot:P39805" /translation="MKIAKVINNNVISVVNEQGKELVVMGRGLAFQKKSGDDVDEARI EKVFTLDNKDVSEKFKTLLYDIPIECMEVSEEIISYAKLQLGKKLNDSIYVSLTDHIN FAIQRNQKGLDIKNALLWETKRLYKDEFAIGKEALVMVKNKTGVSLPEDEAGFIALHI VNAELNEEMPNIINITKVMQEILSIVKYHFKIEFNEESLHYYRFVTHLKFFAQRLFNG THMESQDDFLLDTVKEKYHRAYECTKKIQTYIEREYEHKLTSDELLYLTIHIERVVKQ A*" /label="licT CDS" gene complement(3663980..3664813) /gene="licT" /locus_tag="BSU_39080" /old_locus_tag="BSU39080" /label="licT gene" promotor_-10 complement(3664844..3664863) /Source="Nicolas_upshift_promotors" /id="U3090" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2725 /SigmaFactorBS="agtgaattgtactgaccagcttccgtctttccctgatgaTAT TGACCtagtacaaaaagaATGTACAATCAAGATATAGTctgttcttagtagatttgga g" /listShort="licT, S1507, bglS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3664863) /Source="Nicolas_upshifts" /id="U3090" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2725 /SigmaFactorBS="agtgaattgtactgaccagcttccgtctttccctgatgaTAT TGACCtagtacaaaaagaATGTACAATCAAGATATAGTctgttcttagtagatttgga g" /listShort="licT, S1507, bglS" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3664877..3664884) /Source="Nicolas_upshift_promotors" /id="U3090" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.992007992007992" /psig=1 /xcortree=2725 /SigmaFactorBS="agtgaattgtactgaccagcttccgtctttccctgatgaTAT TGACCtagtacaaaaagaATGTACAATCAAGATATAGTctgttcttagtagatttgga g" /listShort="licT, S1507, bglS" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3664909..3665589) /gene="yxiP" /locus_tag="BSU_39090" /old_locus_tag="BSU39090" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_391788.1" /db_xref="EnsemblGenomes-Gn:BSU39090" /db_xref="EnsemblGenomes-Tr:CAB15945" /db_xref="SubtiList:BG11145" /db_xref="UniProtKB/Swiss-Prot:P42307" /translation="MRRIGLCISLLVTVLVMSACESEGEAQMFADCDQKTVKQTAAKP MSSKKKQDFQALASDRQLAIVFSSMIQVSEAFDYGIGNPEYFVRISMTEEEADIAKEN LESIKLENKSLKKQNSEAVALLQKTRNQDMSRIEIQQLTENRAGFFETADSMIKLINQ VTPKNAKKTRQQLDQLKKQYTQYSAESIKIMNSIVKKQKADKASFERHLEALLQKQPG QQVRSELY*" /label="yxiP CDS" gene complement(3664909..3665589) /gene="yxiP" /locus_tag="BSU_39090" /old_locus_tag="BSU39090" /label="yxiP gene" promotor_-10 complement(3665636..3665655) /Source="Nicolas_upshift_promotors" /id="U3091" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.54045954045954" /psig=1 /xcortree=2984 /SigmaFactorBS="gttttttcgcttcaaatcatacttttgatTTATTGCTggggt taggtgcaTCTGGTACCATTTAACTATAttttatggtattttccagaagggattcagc a" /listShort="yxiP, licT, S1507" /listLong="bglS" /label="promotor_-10" upshifts complement(3665645) /Source="Nicolas_upshifts" /id="U3091" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.54045954045954" /psig=1 /xcortree=2984 /SigmaFactorBS="gttttttcgcttcaaatcatacttttgatTTATTGCTggggt taggtgcaTCTGGTACCATTTAACTATAttttatggtattttccagaagggattcagc a" /listShort="yxiP, licT, S1507" /listLong="bglS" /label="upshifts" promotor_-35 complement(3665669..3665676) /Source="Nicolas_upshift_promotors" /id="U3091" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.54045954045954" /psig=1 /xcortree=2984 /SigmaFactorBS="gttttttcgcttcaaatcatacttttgatTTATTGCTggggt taggtgcaTCTGGTACCATTTAACTATAttttatggtattttccagaagggattcagc a" /listShort="yxiP, licT, S1507" /listLong="bglS" /label="promotor_-35" promotor_-35 3665737..3665740 /Source="Nicolas_upshift_promotors" /id="U3092" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.818181818181818" /psig="0.94005994005994" /xcortree=674 /SigmaFactorBS="agcgaaaaaacataaatattttgtaaaaattgacgtgcattc CATTcttttcaggcccatTTCTCGTACAATAGAAGTATcgttaccggagaggggctct g" /listShort="yxiO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3665755..3665774 /Source="Nicolas_upshift_promotors" /id="U3092" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.818181818181818" /psig="0.94005994005994" /xcortree=674 /SigmaFactorBS="agcgaaaaaacataaatattttgtaaaaattgacgtgcattc CATTcttttcaggcccatTTCTCGTACAATAGAAGTATcgttaccggagaggggctct g" /listShort="yxiO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3665755 /Source="Nicolas_upshifts" /id="U3092" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.818181818181818" /psig="0.94005994005994" /xcortree=674 /SigmaFactorBS="agcgaaaaaacataaatattttgtaaaaattgacgtgcattc CATTcttttcaggcccatTTCTCGTACAATAGAAGTATcgttaccggagaggggctct g" /listShort="yxiO" /GFF_Attribute="listLong" /label="upshifts" CDS 3665796..3667082 /gene="yxiO" /locus_tag="BSU_39100" /old_locus_tag="BSU39100" /function="16.1: Circulate" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12583894, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_391789.1" /db_xref="EnsemblGenomes-Gn:BSU39100" /db_xref="EnsemblGenomes-Tr:CAB15946" /db_xref="GOA:P42306" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR024671" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11144" /db_xref="UniProtKB/Swiss-Prot:P42306" /translation="MMKRFTKQENSWVLYDWANSAYSIVVTTAVFPLFYKSAAAESGV SAAQSTAYLGYTIAISTFILAMLGPILGTIADYEGCKKKFFGFFVSAGVASTAMLAFI PSEHWLLLLLFYTVSAIGFSGANVFYDAFLVDVTPEKRMNLVSARGFGLGYIGSTIPF IISIAVILLAQAETIPVSVSAASQLSFFITAAWWGLFTIPMIKHVHQRYYIKKEPHIV INSFKRLGQTMKRIRQYRALFLFLLAYFFYIDGVGTIITMSTSYGSDLGIGSSSLLII LFVTQVVAAPFSIIYGKLAERFTGKTMLYVGIVIYMIVCVYAYFMETTLDFWILAMLV ATSQGGIQALSRSYFAKLVPKRHANEFFGFYNIFGKFASIMGPLLIAVTAQLTGKSST AVFSLIILFVIGIVILAFVPEETSTDVSQQQNDLPL*" /label="yxiO CDS" gene 3665796..3667082 /gene="yxiO" /locus_tag="BSU_39100" /old_locus_tag="BSU39100" /label="yxiO gene" promotor_-10 complement(3666527..3666545) /Source="Nicolas_upshift_promotors" /id="U3093" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2817 /SigmaFactorBS="cctaaatctgatccataggatgtcgacatCGTAATAAtcgtg ccgactccGTCGATATAAAAGAAATAAgcgagcaagaagaggaaaagtgcccggtatt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3666535) /Source="Nicolas_upshifts" /id="U3093" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2817 /SigmaFactorBS="cctaaatctgatccataggatgtcgacatCGTAATAAtcgtg ccgactccGTCGATATAAAAGAAATAAgcgagcaagaagaggaaaagtgcccggtatt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3666559..3666566) /Source="Nicolas_upshift_promotors" /id="U3093" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2817 /SigmaFactorBS="cctaaatctgatccataggatgtcgacatCGTAATAAtcgtg ccgactccGTCGATATAAAAGAAATAAgcgagcaagaagaggaaaagtgcccggtatt g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3667053 /Source="Nicolas_upshifts" /id="D2036" /incds=0 /nref=1 /ntot=68 /MaxReadThrough="2.50578" /MaxDrop="3.06646" /score="-7.45683354" /energy="-16.7" /TU="NA" /idTUdmin="U3092" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3667101..3668540) /gene="deaD" /locus_tag="BSU_39110" /old_locus_tag="BSU39110" /function="16.2: Construct biomass (Anabolism)" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:10481020, 16118224, 16611943, 17142894, 17229151, 17951299, 19839642, 20691700, 26755693" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10481020, 16118224, 16611943, 17142894, 17229151, 17951299, 19839642, 20691700, 26755693; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ATP-dependent RNA helicase for 23S ribosomal RNAmaturation" /protein_id="NP_391790.2" /db_xref="EnsemblGenomes-Gn:BSU39110" /db_xref="EnsemblGenomes-Tr:CAB15947" /db_xref="GOA:P42305" /db_xref="InterPro:IPR000629" /db_xref="InterPro:IPR001650" /db_xref="InterPro:IPR005580" /db_xref="InterPro:IPR011545" /db_xref="InterPro:IPR014001" /db_xref="InterPro:IPR014014" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR028619" /db_xref="PDB:2G0C" /db_xref="PDB:2HJV" /db_xref="PDB:3MOJ" /db_xref="SubtiList:BG11143" /db_xref="UniProtKB/Swiss-Prot:P42305" /translation="MSHFKNYQISHDILRALEGLGYTEPTKVQQSVIPAALERKDLVV KSQTGSGKTASFGIPLCELANWDENKPQALILTPTRELAVQVKEDITNIGRFKRIKAT AVFGKSSFDKQKAELKQKSHIVVGTPGRVLDHIEKGTLPLDRLSYLVIDEADEMLNMG FIEQVEAIIKHLPTERTTMLFSATLPQDIEKLSRQYMQNPEHIEVKAAGLTTRNIEHA VIQVREENKFSLLKDVLMTENPDSCIIFCRTKEHVNQLTDELDDLGYPCDKIHGGMIQ EDRFDVMNEFKRGEYRYLVATDVAARGIDIENISLVINYDLPLEKESYVHRTGRTGRA GNKGKAISFVTAFEKRFLADIEEYIGFEIQKIEAPSQEEVARKKPEFLAKLNDRPESK KDKSEELNKDIMKLYFNGGKKKKIRAVDFVGTIAKIDGVSADDIGIITIMDNASYVEI LNGKGPHVLKVMKNTTVKGKQLKVNKANK*" /label="deaD CDS" gene complement(3667101..3668540) /gene="deaD" /locus_tag="BSU_39110" /old_locus_tag="BSU39110" /label="deaD gene" downshifts complement(3667124) /Source="Nicolas_upshifts" /id="D2037" /incds=0 /nref=200 /ntot=269 /MaxReadThrough="1.50578" /MaxDrop="5.83238" /score="3.28924902" /energy="-18.2" /TU="NA" /idTUdmin="U3095" /TUdmin=5 /isTUend="TRUE" /label="downshifts" misc_feature complement(3668564..3668583) /Source="Nicolas_upshift_promotors" /id="U3094" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.496503496503497" /psig="0.56943056943057" /xcortree=1449 /SigmaFactorBS="agggaatcgctggcttttaatacatcatttttcgacaaaaca catatgccttggtcaaTTAGAGTATAATGAGAACATctgcaagagacaggagtttata c" /listShort="deaD" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3668581) /Source="Nicolas_upshifts" /id="U3094" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.496503496503497" /psig="0.56943056943057" /xcortree=1449 /SigmaFactorBS="agggaatcgctggcttttaatacatcatttttcgacaaaaca catatgccttggtcaaTTAGAGTATAATGAGAACATctgcaagagacaggagtttata c" /listShort="deaD" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3668622..3669770) /gene="yxiM" /locus_tag="BSU_39120" /old_locus_tag="BSU39120" /EC_number="3.1.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 10746760, 25394512; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="esterase (lipoprotein)" /protein_id="NP_391791.2" /db_xref="EnsemblGenomes-Gn:BSU39120" /db_xref="EnsemblGenomes-Tr:CAB15948" /db_xref="GOA:P42304" /db_xref="InterPro:IPR008979" /db_xref="InterPro:IPR013830" /db_xref="InterPro:IPR036514" /db_xref="PDB:2O14" /db_xref="SubtiList:BG11142" /db_xref="UniProtKB/Swiss-Prot:P42304" /translation="MKKWMAAVFVMMLMLCFGGIENVKAAEPKVYQFDFGSGSMEPGY IGVRASDRYDRSKGYGFQTPENMRDVAASGAGVKSDAVQFLAYGTKSNNTFNVDLPNG LYEVKVTLGNTARASVAAEGVFQVINMTGDGAEDTFQIPVTDGQLNLLVTEGKAGTAF TLSALKIKKLSDQPVTNRTIYVGGDSTVCNYYPLNSSKQAGWGQMLPHYIDKHTFQVR NMASGGQIARGFRNDGQLEAILKYIKPGDYFMLQLGINDTNPKHKESEAEFKEVMRDM IRQVKAKGADVILSTPQGRATDFTSEGIHSSVNRWYRASILALAEEEKTYLIDLNVLS SAYFTSIGPERTLGLYMDGDTLHPNRAGADALARLAVQELKRQGIAGF*" /label="yxiM CDS" gene complement(3668622..3669770) /gene="yxiM" /locus_tag="BSU_39120" /old_locus_tag="BSU39120" /label="yxiM gene" promotor_-10 complement(3669797..3669813) /Source="Nicolas_upshift_promotors" /id="U3095" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.466533466533467" /psig="0.466533466533467" /xcortree=812 /SigmaFactorBS="catttttattcctcaacgcaatttttttcttaattcagtcAT CATAaagaaacaatcaccGAGTATGCATTAATGTAttcgttttcatagagggggagtc t" /listShort="yxiM, deaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3669813) /Source="Nicolas_upshifts" /id="U3095" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.466533466533467" /psig="0.466533466533467" /xcortree=812 /SigmaFactorBS="catttttattcctcaacgcaatttttttcttaattcagtcAT CATAaagaaacaatcaccGAGTATGCATTAATGTAttcgttttcatagagggggagtc t" /listShort="yxiM, deaD" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3669815..3669899) /Source="Nicolas_S_feature" /locus_tag="new_4018701_4018785_c" /HighExp="T3.30H, T4.0H, T2.30H, T3.0H, T2.0H, T-3.40H, T5.0H, T-2.40H, Lbexp, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1508" promotor_-35 complement(3669828..3669833) /Source="Nicolas_upshift_promotors" /id="U3095" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.466533466533467" /psig="0.466533466533467" /xcortree=812 /SigmaFactorBS="catttttattcctcaacgcaatttttttcttaattcagtcAT CATAaagaaacaatcaccGAGTATGCATTAATGTAttcgttttcatagagggggagtc t" /listShort="yxiM, deaD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3669900..3670088) /gene="yxzI" /locus_tag="BSU_39129" /old_locus_tag="BSU39129" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="PSEUDO:CAX52710.1" /translation="MRFENISASKLDDLESIDSVALEIVPTDDQWERLRYYVYDEENQ ISFYCGGWDVIKCDKKSH*" /label="yxzI CDS" gene complement(3669900..3670088) /gene="yxzI" /locus_tag="BSU_39129" /old_locus_tag="BSU39129" /pseudo /label="yxzI gene" CDS complement(3670119..3670250) /gene="yxzJ" /locus_tag="BSU_39139" /old_locus_tag="BSU39139" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097796.1" /db_xref="EnsemblGenomes-Gn:BSU39139" /db_xref="EnsemblGenomes-Tr:CAX52711" /db_xref="UniProtKB/Swiss-Prot:C0H3T5" /translation="MNITQYEKLKQHLSDEDTGPFTLNEFSFYMKEDDRYIHIPVFE* " /label="yxzJ CDS" gene complement(3670119..3670250) /gene="yxzJ" /locus_tag="BSU_39139" /old_locus_tag="BSU39139" /label="yxzJ gene" CDS complement(3670262..3670723) /gene="yxiK" /locus_tag="BSU_39140" /old_locus_tag="BSU39140" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; Product type f: factor" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391793.1" /db_xref="EnsemblGenomes-Gn:BSU39140" /db_xref="EnsemblGenomes-Tr:CAB15950" /db_xref="SubtiList:BG11140" /db_xref="UniProtKB/Swiss-Prot:P42302" /translation="MEITSISSIGNLDMIELKPDQTVMACELEDAESFYRFWAGLAYD RIMIQVITTGSFIEDLSEYFEGHAYKVTKLAKREFHFQSILQEADRDIADFLFLLASI NDDVFLITDPQPDKSYFSEGKLQCLTDSGERIIWFEYDAVDIYMIGGESYK*" /label="yxiK CDS" gene complement(3670262..3670723) /gene="yxiK" /locus_tag="BSU_39140" /old_locus_tag="BSU39140" /label="yxiK gene" CDS complement(3670739..3671035) /gene="yxiJ" /locus_tag="BSU_39150" /old_locus_tag="BSU39150" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391794.1" /db_xref="EnsemblGenomes-Gn:BSU39150" /db_xref="EnsemblGenomes-Tr:CAB15951" /db_xref="InterPro:IPR025551" /db_xref="SubtiList:BG11139" /db_xref="UniProtKB/Swiss-Prot:P42320" /translation="MLQKLRKRQRELEEKQYPDELYGFEAEIYEFFMLVAGSLDYVLA NKRIPRHQRRSLEKSFFELYPDILPDMIKNDKDLYHHILLYEQVRQEICVALSN*" /label="yxiJ CDS" gene complement(3670739..3671035) /gene="yxiJ" /locus_tag="BSU_39150" /old_locus_tag="BSU39150" /label="yxiJ gene" CDS complement(3671063..3671551) /gene="yxiI" /locus_tag="BSU_39160" /old_locus_tag="BSU39160" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391795.1" /db_xref="EnsemblGenomes-Gn:BSU39160" /db_xref="EnsemblGenomes-Tr:CAB15952" /db_xref="InterPro:IPR020323" /db_xref="SubtiList:BG11138" /db_xref="UniProtKB/Swiss-Prot:P42301" /translation="MMNWRALSQTKQDRIWSEVNKIIKWKPGSRCHHIIPPDPYRVFD ISSAMSSKAGHNDVSGVLSDLETSILKAFQLGTGKNDVMYALDWQHDGYTFSPHQAMP KDEFGEWPVPVFPNGDYYFFFHQDFSWGLLGDPWKCAITVFGEELLEAIDNDPPILFR NK*" /label="yxiI CDS" gene complement(3671063..3671551) /gene="yxiI" /locus_tag="BSU_39160" /old_locus_tag="BSU39160" /label="yxiI gene" CDS complement(3671569..3672021) /gene="yxzG" /locus_tag="BSU_39170" /old_locus_tag="BSU39170" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative nucleic acid binding protein" /protein_id="NP_391796.1" /db_xref="EnsemblGenomes-Gn:BSU39170" /db_xref="EnsemblGenomes-Tr:CAB15953" /db_xref="SubtiList:BG14170" /db_xref="UniProtKB/Swiss-Prot:O32285" /translation="MWCFTLDGQQKEIHIDRKLEEMDAPAVDDCYGLAEKNGLIYMLY YGDAVIAAFDETVVRRVWILSDKEPDSEAFDQLAISEEGFLVGTFNCYSADLKSSLYL ISADVSQEMEEITCCDSNGEGLDVQQLKLTSYAVYAVASSGVYKQDIQ*" /label="yxzG CDS" gene complement(3671569..3672021) /gene="yxzG" /locus_tag="BSU_39170" /old_locus_tag="BSU39170" /label="yxzG gene" S_feature complement(3672022..3672090) /Source="Nicolas_S_feature" /locus_tag="new_4020908_4020976_c" /HighExp="T4.0H, T3.30H, T3.0H, T2.30H, T2.0H, T-3.40H, T5.0H, T-2.40H, T-4.40H, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.19384199999999999" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1509" CDS complement(3672091..3672420) /gene="yxiH" /locus_tag="BSU_39180" /old_locus_tag="BSU39180" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391797.1" /db_xref="EnsemblGenomes-Gn:BSU39180" /db_xref="EnsemblGenomes-Tr:CAB15954" /db_xref="InterPro:IPR011042" /db_xref="SubtiList:BG11137" /db_xref="UniProtKB/Swiss-Prot:P42300" /translation="MKKLKLNKIINENTQDCFFHADPQGRVYIGKGLKGGITITIYDP SGDVRDFRVKEQISYSDILLFQQCADGYVFVYYESYEPKVKVFSEEGRVKSVFHLPSG VSCCLLD*" /label="yxiH CDS" gene complement(3672091..3672420) /gene="yxiH" /locus_tag="BSU_39180" /old_locus_tag="BSU39180" /label="yxiH gene" S_feature complement(3672421..3672542) /Source="Nicolas_S_feature" /locus_tag="new_4021307_4021428_c" /HighExp="T3.30H, T4.0H, T3.0H, T2.30H, T-4.40H, T-3.40H, LBGexp, T-2.40H, T2.0H, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1510" CDS complement(3672543..3672959) /gene="yxiG" /locus_tag="BSU_39190" /old_locus_tag="BSU39190" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391798.1" /db_xref="EnsemblGenomes-Gn:BSU39190" /db_xref="EnsemblGenomes-Tr:CAB15955" /db_xref="SubtiList:BG11136" /db_xref="UniProtKB/Swiss-Prot:P42299" /translation="MTMYQTINEWVDYIDKGCSVLHLDFNVFKKELSLDIKVFEDEGE YTHKISFQNVASAYYSADVGDMRLEKIDPEEYNWQVFEMSYHPEGIGNLSNSIIPEYQ SNANFLIDMNRMLIAIEAETVRFDDQSFYAYQLNTK*" /label="yxiG CDS" gene complement(3672543..3672959) /gene="yxiG" /locus_tag="BSU_39190" /old_locus_tag="BSU39190" /label="yxiG gene" CDS complement(3673010..3673378) /gene="yxzC" /locus_tag="BSU_39200" /old_locus_tag="BSU39200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative nucleic acid binding protein" /protein_id="NP_391799.1" /db_xref="EnsemblGenomes-Gn:BSU39200" /db_xref="EnsemblGenomes-Tr:CAB15956" /db_xref="SubtiList:BG14167" /db_xref="UniProtKB/Swiss-Prot:O32286" /translation="MVDWKPFGTYLLRKKLQYLNISTVLCILIKNHLVLEYVVIKLSE TNLIECINKIKSVLNGQTTREEVSDWAGTYVYADDPEVEDDRVWDMLILLSGIDLKDS SETYLHSTDDLNDWIKQYTE*" /label="yxzC CDS" gene complement(3673010..3673378) /gene="yxzC" /locus_tag="BSU_39200" /old_locus_tag="BSU39200" /label="yxzC gene" CDS complement(3673372..3673842) /gene="yxiF" /locus_tag="BSU_39210" /old_locus_tag="BSU39210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391800.1" /db_xref="EnsemblGenomes-Gn:BSU39210" /db_xref="EnsemblGenomes-Tr:CAB15957" /db_xref="SubtiList:BG11135" /db_xref="UniProtKB/Swiss-Prot:P42298" /translation="MQKRLIEKLAENKRRLLMSEIKEKLVPCAERGFTYRFADLAQSR QLLELVLSNSIPANTREVDALEKTEAKQLIWKISQSYVAYDDRDVLLFHQYSSEIGAL VCSFGKCLEHLDCLLECIEFDEGILNHSFILVEPKCQFGLCILHTEYGCELVYW*" /label="yxiF CDS" gene complement(3673372..3673842) /gene="yxiF" /locus_tag="BSU_39210" /old_locus_tag="BSU39210" /label="yxiF gene" S_feature complement(3673843..3674167) /Source="Nicolas_S_feature" /locus_tag="new_4022729_4023053_c" /HighExp="T3.30H, T-2.40H, T2.30H, T3.0H, T4.0H, SMMPr, MG 120, C90, T2.0H, T-4.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1511" CDS complement(3674168..3674596) /gene="wapI" /locus_tag="BSU_39220" /old_locus_tag="BSU39220" /experiment="publication(s) with functional evidences, PMID:1529529, 16306698, 19763274, 23572593" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1529529, 16306698, 19763274, 23572593; Product type f: factor" /codon_start=1 /transl_table=11 /product="antitoxin of WapA tRNase" /protein_id="NP_391801.1" /db_xref="EnsemblGenomes-Gn:BSU39220" /db_xref="EnsemblGenomes-Tr:CAB15958" /db_xref="SubtiList:BG10798" /db_xref="UniProtKB/Swiss-Prot:Q07836" /translation="MAKIKDDCIELELTPRRYQELDDDPFILSVFELLENKKAVVRDF SAVLLESEYKVLISGIETMIKGNQDSISLETIEPFLFLSIDQENGNYRIKIKIIFDDY KESKSNSNLFEINCNEEKLESFVTALKLNLENTKNPSKLP*" /label="wapI CDS" gene complement(3674168..3674596) /gene="wapI" /locus_tag="BSU_39220" /old_locus_tag="BSU39220" /label="wapI gene" CDS complement(3674658..3681662) /gene="wapA" /locus_tag="BSU_39230" /old_locus_tag="BSU39230" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8316082, 9537385, 16306698, 16849803, 21636651, 23199363, 23572593, 23944997, 25666134, 28827522" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8316082, 9537385, 16306698, 16849803, 21636651, 23199363, 23572593, 23944997, 25666134, 28827522; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="cell wall-associated tRNA nuclease precursor; intercellular growth inhibitor" /protein_id="NP_391802.2" /db_xref="EnsemblGenomes-Gn:BSU39230" /db_xref="EnsemblGenomes-Tr:CAB15959" /db_xref="GOA:Q07833" /db_xref="InterPro:IPR006530" /db_xref="InterPro:IPR008979" /db_xref="InterPro:IPR013783" /db_xref="InterPro:IPR022385" /db_xref="InterPro:IPR031325" /db_xref="SubtiList:BG10797" /db_xref="UniProtKB/Swiss-Prot:Q07833" /translation="MKKRKRRNFKRFIAAFLVLALMISLVPADVLAKSTEEENGNRIA ADDPEETLQKEQTEEAVPFDPKDINKEGEITSERTENTKLYYEGDGVYKQEVYLDPIH TKETPDADWEDISPELKESTSKQVETENAILNSDFQKQMKNGLYATFEHNDHKVTYSL AEAKGPNKTSLTPKDTSADYKTDSNEIVYPDVFPNIDLQTFTFNENIKEDLVLHQYNG YNTFTFQLKTDLQAKEQEDGSIDFSDEKGKVVFSVPKPFMTDSKLDELSGEVERSDKV SYKLEKNEEGYLLHLTADENWLKDPERVYPVSIDPSTSLSVSSDTFVMSAYPTTNYSA SSQKWDANLKAYVLKTGYYDKTTGTNYAFMKFNNLKPIQNMTVTKATLKTYVAHSYYG TKATGLWLDTVNSNYDNAKVTWNTKPASKNIGKADVHKGQWASYDVTAAVKSWNSGGA NYGFKLHTNGNGKEYWKKLISSANSANKPYIEVTYTIPKGNTPTIKAYHNGDSTGYFD ISWKKVEGAKGYKVWIYNGKEYQAISAGNVTSWSTKGKKIWPTSAEIASKRYKLHLDG KDGAELALDPSPVYKNSGGSYATSKNYWIGVSAIFDQGEGAMSAPAKPVIPNVGKAQA PSAKGYNNGNATGYFDLSWKAVSGATGYKVQVFNGKGFETLDLGNQTSWTTKGKKIWP TSAEIKAGKYALHLKDGSGAELPINPGPTYKNAGGDGAKRNYSFKIIAYNKDGEAIAS PAATPALPDIARPKNVTGYLYTNTKSSQTGYVNLIWEKVQNAKGYKVNIYNGKEYQSF DVGDADHWTTQNKNIWPTSEEIKAGSYKLHTDGKGGELALDPSPVYNNANGNYKGKKN YSFTLVAYDANGETIPTAPFNPTFHEGAEFLGTEEYWSIIDIPSGQLNGATGNVIVNE EDLSIDGRGPGLGLSRTYNSLDSSDHLFGQGWYADAETSVISTDGGAMYIDEDATTHR FTKKADGTYQPPTGVYLELTETADQFILKTKDQTNAYFNKKGGKLQKVVDGHNNATVY TYNDKNQLTAITDASGRKLTFTYDENGHVTSITGPKNKKVTYSYENDLLKKVTDTDGT VTSYDYDSEGRLVKQYSANSTEAKPVFTEYQYSGHRLEKAINAKKETYVYSYDADKKT LLMTQPNGRKVQYGYNEAGNPIQVIDDAEGLKITTNTKYEGNNVVEDVDPNDVGTGKA TESYQYDKDGNVTSVKDAYGTETYEYNKNNDVTKMKDTEGNVTDIAYDGLDAVSETDQ SGKSSSAAVYDKYGNQIQSSKDLSASTNILKDGSFEAQKSGWNLTASKDSGKISVIAD KSGVLSGSKALEVLSQSTSAGTDHGYSSATQTVELEPNTTYTLSGKIKTDLAKSRAYF NIDLRDKDQKRIQWIHNEYSALAGKNDWTKRQITFTTPANAGKAVVYMEVDHKDKDGK GKAWFDEVQLEKGEVSSSYNPVQNSSFTSATENWNVSGASVDSEEGFNDDVSLKAART SASQAGSVTKQTVVLGQSANDKPVYLTLTGMSKASSVKFTDEKDYSLQANVTYADGST GIYNAKFPSGTQEWNRAAVVIPKTKPINKVDISILFQKSATGTVWFDDIRLIEGSLLT KSTYDSNGNYVTKEEDELGYATSTDYDETGKKTSETDAKGEKTTYTYDQADQLTNMTL SNGTSILHSYDKEGNEVSKTIRAGADQTYKFEYDVMGKLVKTTDPLGNVLASEYDANS NLTKTISPNGNEVSLSYDGTDRVKSKSYNGTEKYIFTYDKNGNETSVVNKEQNTTKKR TFDNKNRLTELTDRGGSQTWTYPSDSDKLKTFSWIHGDQKGTNQFTYNKLDQMIEMKD STSSYSFDYDENGNVQTFITGNGGGTSFSYDERNLVSSLHIGDKNGGDILTESYEYDA NGNRTTINSSASGKVQYEYGKLNQLVKETHEDGTVIEYTYDGFGNRKTVTTIKDGSSK TVNASFNIMNQLTKVNDESISYDKNGNRTSDGKFTYTWDAEDNLTAVTKKGEDKPFAT YKYDEKGNRIQKTVNGKVTNYFYDGDSLNVLYETDADNNVTKSYTYGDSGQLLSYTEN GKKYFYHYNAHGDIIAISDSTGKTVAKYQYDAWGNPTKTEASDEVKDNRYRYAGYQYD EETGLYYLMARYYEPRNGVFLSLDPDPGSDGDSLDQNGYAYGNNNPVMNVDPDGHWVW LVVNAGFAAYDGYKAYKSGKGWKGAAWAAASNFGPGKIFKGASRAYKFTKKAVKITGH TRHGLNQSIGRNGGRGVNLRAKLNAVRSPKKVIKQPNGATKYVGKKATVVLNKRGKVI TAYGSSRAKGSKHVFHTHGKGNKSKRRR*" /label="wapA CDS" gene complement(3674658..3681662) /gene="wapA" /locus_tag="BSU_39230" /old_locus_tag="BSU39230" /label="wapA gene" misc_feature 3681669..3681683 /Source="Nicolas_upshift_promotors" /id="U3096" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.896103896103896" /psig="0.0919080919080919" /xcortree=301 /SigmaFactorBS="caatgaaccttttaaagtttcgcctctttctttttttcattt cctcTCTCCTTTTGTAATAaaagtaatatttactcaataatcttaactagactgaaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3681683 /Source="Nicolas_upshifts" /id="U3096" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.896103896103896" /psig="0.0919080919080919" /xcortree=301 /SigmaFactorBS="caatgaaccttttaaagtttcgcctctttctttttttcattt cctcTCTCCTTTTGTAATAaaagtaatatttactcaataatcttaactagactgaaat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3681693..3681712) /Source="Nicolas_upshift_promotors" /id="U3097" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.917082917082917" /psig=1 /xcortree=2783 /SigmaFactorBS="taatccttaaaataagataaattttctagaaaaaTATTGTAA tgatatttcagtctAGTTAAGATTATTGAGTAAAtattacttttattacaaaaggaga g" /listShort="wapA, yxxG, S1511, yxiF, yxzC, yxiG, S1510, yxiH, S1509, yxzG, yxiI, yxiJ, yxiK, yxzJ, yxzI, S1508, yxiM, deaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3681708) /Source="Nicolas_upshifts" /id="U3097" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.917082917082917" /psig=1 /xcortree=2783 /SigmaFactorBS="taatccttaaaataagataaattttctagaaaaaTATTGTAA tgatatttcagtctAGTTAAGATTATTGAGTAAAtattacttttattacaaaaggaga g" /listShort="wapA, yxxG, S1511, yxiF, yxzC, yxiG, S1510, yxiH, S1509, yxzG, yxiI, yxiJ, yxiK, yxzJ, yxzI, S1508, yxiM, deaD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3681727..3681734) /Source="Nicolas_upshift_promotors" /id="U3097" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.917082917082917" /psig=1 /xcortree=2783 /SigmaFactorBS="taatccttaaaataagataaattttctagaaaaaTATTGTAA tgatatttcagtctAGTTAAGATTATTGAGTAAAtattacttttattacaaaaggaga g" /listShort="wapA, yxxG, S1511, yxiF, yxzC, yxiG, S1510, yxiH, S1509, yxzG, yxiI, yxiJ, yxiK, yxzJ, yxzI, S1508, yxiM, deaD" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3681824..3682759) /gene="yxxF" /locus_tag="BSU_39240" /old_locus_tag="BSU39240" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_391803.1" /db_xref="EnsemblGenomes-Gn:BSU39240" /db_xref="EnsemblGenomes-Tr:CAB15960" /db_xref="GOA:Q07835" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG10796" /db_xref="UniProtKB/Swiss-Prot:Q07835" /translation="MQQDPSISSKQKSTAVIKMVISMVIFGSIGFFSEHTNLPSFELV FVRCLCATLFLGFCWLASGQYKTEKWSKRDVLQTLACGFFLVFNWVFLFKSFEETSVT IAISVYHLAPVLVLLLGSFFYREKLNVISVSSIIICFLGTALISGINGSTSLTQLMGS GIIWAVLAALFYAFTTLLGKGIHNLSPYTTTFLQTGLGVIILIPFIHFGAFADLSQGN WIMVVSTGIIHTGIVYLLFFDSLRFLSTKFISIIVFLDPAVAIVLDTVFTGFRPDLYQ TLGIVMIFAGMALTLVRRQGKANVTAEGTDIEQIQ*" /label="yxxF CDS" gene complement(3681824..3682759) /gene="yxxF" /locus_tag="BSU_39240" /old_locus_tag="BSU39240" /label="yxxF gene" downshifts complement(3682045) /Source="Nicolas_upshifts" /id="D2038" /incds=1 /nref=1 /ntot=153 /MaxReadThrough="1.33481" /MaxDrop="2.42407" /score="29.0290332" /energy="-5.9" /TU="NA" /idTUdmin="U3098" /TUdmin=22 /isTUend="TRUE" /label="downshifts" S_feature complement(3682760..3682880) /Source="Nicolas_S_feature" /locus_tag="new_4031646_4031766_c" /HighExp="T3.0H, T1.0H, T3.30H, LBGstat, T1.30H, T0.30H, T4.0H, M9-stat, T2.30H, T0.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="Sig-" /TUlongPSig="0.196" /label="S1512" CDS complement(3682911..3683357) /gene="yxiE" /locus_tag="BSU_39250" /old_locus_tag="BSU39250" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10913081, 12644671, 17210127" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10913081, 12644671, 17210127; Product type f: factor" /codon_start=1 /transl_table=11 /product="phosphate starvation protein (universal stress protein A family)" /protein_id="NP_391804.1" /db_xref="EnsemblGenomes-Gn:BSU39250" /db_xref="EnsemblGenomes-Tr:CAB15961" /db_xref="GOA:P42297" /db_xref="InterPro:IPR006015" /db_xref="InterPro:IPR006016" /db_xref="InterPro:IPR014729" /db_xref="SubtiList:BG11134" /db_xref="UniProtKB/Swiss-Prot:P42297" /translation="MFNKMLVAIDGSDMSAKALDAAVHLAKEQQAELSILHVGREAVV TTSSLTGIVYVPEHFIDEIRNEVKKEGLKILENAKEKAAEKGVQAETIYANGEPAHEI LNHAKEKGVSLIVVGSRGISGLKEMMLGSVSHKVSQLSTCPVLIVR*" /label="yxiE CDS" gene complement(3682911..3683357) /gene="yxiE" /locus_tag="BSU_39250" /old_locus_tag="BSU39250" /label="yxiE gene" downshifts complement(3682925) /Source="Nicolas_upshifts" /id="D2039" /incds=0 /nref=22 /ntot=144 /MaxReadThrough="4.33955" /MaxDrop="6.75522" /score="45.6082379" /energy="-8.4" /TU="U3098" /idTUdmin="U3099" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3683394..3683413) /Source="Nicolas_upshift_promotors" /id="U3098" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.56943056943057" /psig="0.998001998001998" /xcortree=1609 /SigmaFactorBS="gacaattttttgaaaactcatgcgcttCAATTGACaataacg aaatgcAGGCGGACAATAAAAGAGAAagatgaaccacccacagtccgaaaggcgggaa g" /listShort="yxiE, S1512, yxxF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3683401) /Source="Nicolas_upshifts" /id="U3098" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.56943056943057" /psig="0.998001998001998" /xcortree=1609 /SigmaFactorBS="gacaattttttgaaaactcatgcgcttCAATTGACaataacg aaatgcAGGCGGACAATAAAAGAGAAagatgaaccacccacagtccgaaaggcgggaa g" /listShort="yxiE, S1512, yxxF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3683427..3683434) /Source="Nicolas_upshift_promotors" /id="U3098" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.56943056943057" /psig="0.998001998001998" /xcortree=1609 /SigmaFactorBS="gacaattttttgaaaactcatgcgcttCAATTGACaataacg aaatgcAGGCGGACAATAAAAGAGAAagatgaaccacccacagtccgaaaggcgggaa g" /listShort="yxiE, S1512, yxxF" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3683460..3684869) /gene="bglH" /locus_tag="BSU_39260" /old_locus_tag="BSU39260" /EC_number="3.2.1.86" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14652714, 15139916" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14652714, 15139916; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aryl-phospho-beta-d-glucosidase" /protein_id="NP_391805.2" /db_xref="EnsemblGenomes-Gn:BSU39260" /db_xref="EnsemblGenomes-Tr:CAB15962" /db_xref="GOA:P40740" /db_xref="InterPro:IPR001360" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR018120" /db_xref="InterPro:IPR033132" /db_xref="SubtiList:BG10935" /db_xref="UniProtKB/Swiss-Prot:P40740" /translation="MSSNEKRFPEGFLWGGAVAANQVEGAYNEGGKGLSTADVSPNGI MSPFDESMTSLNLYHNGIDFYHRYKEDIALFAEMGFKAFRTSIAWTRIFPNGDEEEPN EEGLRFYDDLFDELLKHHIEPVVTISHYEMPLGLVKNYGGWKNRKVIEFYERYAKTVF KRYQHKVKYWMTFNEINVVLHAPFTGGGLVFEEGENKLNAMYQAAHHQFVASALAVKA GHDIIPDSKIGCMIAATTTYPMTSKPEDVFAAMENERKTLFFSDVQARGAYPGYMKRY LAENNIEIEMAEGDEELLKEHTVDYIGFSYYMSMAASTDPEELAKSGGNLLGGVKNPY LKSSEWGWQIDPKGLRITLNTLYDRYQKPLFIVENGLGAVDKVEEDGTIQDDYRINYL RDHLIEAREAIADGVELIGYTSWGPIDLVSASTAEMKKRYGFIYVDRDNEGNGTFNRI KKKSFNWYQQVIATNGESL*" /label="bglH CDS" gene complement(3683460..3684869) /gene="bglH" /locus_tag="BSU_39260" /old_locus_tag="BSU39260" /label="bglH gene" CDS complement(3684892..3686721) /gene="bglP" /locus_tag="BSU_39270" /old_locus_tag="BSU39270" /EC_number="2.7.1.-" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15849754, 16850406, 17074746, 8626332" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15849754, 16850406, 17074746, 8626332; Product type t: transporter" /codon_start=1 /transl_table=11 /product="phosphotransferase system (PTS) beta-glucoside-specific enzyme IIBCA component" /protein_id="NP_391806.2" /db_xref="EnsemblGenomes-Gn:BSU39270" /db_xref="EnsemblGenomes-Tr:CAB15963" /db_xref="GOA:P40739" /db_xref="InterPro:IPR001127" /db_xref="InterPro:IPR001996" /db_xref="InterPro:IPR003352" /db_xref="InterPro:IPR011055" /db_xref="InterPro:IPR011297" /db_xref="InterPro:IPR013013" /db_xref="InterPro:IPR018113" /db_xref="InterPro:IPR036878" /db_xref="SubtiList:BG10934" /db_xref="UniProtKB/Swiss-Prot:P40739" /translation="MDYDKLSKDILQLVGGEENVQRVIHCMTRLRFNLHDNAKADRSQ LEQLPGVMGTNISGEQFQIIIGNDVPKVYQAIVRHSNLSDEKSAGSSSQKKNVLSAVF DVISGVFTPILPAIAGAGMIKGLVALAVTFGWMAEKSQVHVILTAVGDGAFYFLPLLL AMSAARKFGSNPYVAAAIAAAILHPDLTALLGAGKPISFIGLPVTAATYSSTVIPILL SIWIASYVEKWIDRFTHASLKLIVVPTFTLLIVVPLTLITVGPLGAILGEYLSSGVNY LFDHAGLVAMILLAGTFSLIIMTGMHYAFVPIMINNIAQNGHDYLLPAMFLANMGQAG ASFAVFLRSRNKKFKSLALTTSITALMGITEPAMYGVNMRLKKPFAAALIGGAAGGAF YGMTGVASYIVGGNAGLPSIPVFIGPTFIYAMIGLVIAFAAGTAAAYLLGFEDVPSDG SQQPAVHEGSREIIHSPIKGEVKALSEVKDGVFSAGVMGKGFAIEPEEGEVVSPVRGS VTTIFKTKHAIGITSDQGAEILIHIGLDTVKLEGQWFTAHIKEGDKVAPGDPLVSFDL EQIKAAGYDVITPVIVTNTDQYSFSPVKEIGKVQPKEALLALS*" /label="bglP CDS" gene complement(3684892..3686721) /gene="bglP" /locus_tag="BSU_39270" /old_locus_tag="BSU39270" /label="bglP gene" promotor_no_box complement(3686713..3686813) /Source="Nicolas_upshift_promotors" /id="U3099" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.362637362637363" /psig="0.195804195804196" /xcortree=1562 /SigmaFactorBS="ttaggaggtgatgcagcatttgatacaaaaaaagctggtgaa aggcggccacctttcatccagcagtccccccataaaaaggaggtatacacatggatta t" /listShort="bglP, bglH, yxiE" /listLong="S1512, yxxF" /label="promotor_no_box" upshifts complement(3686753) /Source="Nicolas_upshifts" /id="U3099" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.362637362637363" /psig="0.195804195804196" /xcortree=1562 /SigmaFactorBS="ttaggaggtgatgcagcatttgatacaaaaaaagctggtgaa aggcggccacctttcatccagcagtccccccataaaaaggaggtatacacatggatta t" /listShort="bglP, bglH, yxiE" /listLong="S1512, yxxF" /label="upshifts" S_feature complement(3686755..3686947) /Source="Nicolas_S_feature" /locus_tag="new_4035641_4035833_c" /HighExp="Diami, T0.30H, B60, T0.0H, G150, M9-stat, T1.0H, T1.30H, Gly, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.29980099999999998" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="0.998, 0.994, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1513" promotor_-10 complement(3686928..3686947) /Source="Nicolas_upshift_promotors" /id="U3100" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.688311688311688" /psig="0.998001998001998" /xcortree=1563 /SigmaFactorBS="cttttgttctagaaacgatagtcaacaccaaaaatgaaagCG TTGACAtctcacgaatctAGTGCTAAAGTATACCTACAaacaaataaaacgacccgtc a" /listShort="S1513, bglP, bglH, yxiE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3686947) /Source="Nicolas_upshifts" /id="U3100" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.688311688311688" /psig="0.998001998001998" /xcortree=1563 /SigmaFactorBS="cttttgttctagaaacgatagtcaacaccaaaaatgaaagCG TTGACAtctcacgaatctAGTGCTAAAGTATACCTACAaacaaataaaacgacccgtc a" /listShort="S1513, bglP, bglH, yxiE" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3686949..3687082) /Source="Nicolas_S_feature" /locus_tag="new_4035835_4035968_c" /HighExp="S2, HiTm, Sw, S8, M9-stat, Lbstat, S0, T2.0H, Mal, S1" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.994, 0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1514" promotor_-35 complement(3686960..3686967) /Source="Nicolas_upshift_promotors" /id="U3100" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.688311688311688" /psig="0.998001998001998" /xcortree=1563 /SigmaFactorBS="cttttgttctagaaacgatagtcaacaccaaaaatgaaagCG TTGACAtctcacgaatctAGTGCTAAAGTATACCTACAaacaaataaaacgacccgtc a" /listShort="S1513, bglP, bglH, yxiE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3687104..3687412) /gene="yxxE" /locus_tag="BSU_39280" /old_locus_tag="BSU39280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391807.1" /db_xref="EnsemblGenomes-Gn:BSU39280" /db_xref="EnsemblGenomes-Tr:CAB15964" /db_xref="SubtiList:BG11071" /db_xref="UniProtKB/Swiss-Prot:P40738" /translation="MLLINKQKDPVFQFLAGTFHQDIETPDDAIQELLIEESKEYLED AIVFLTDFIESEHSDNKKNDYIQSCADGVYLPAFNLEPIDWLKNVIVQIKKSLKKFKR *" /label="yxxE CDS" gene complement(3687104..3687412) /gene="yxxE" /locus_tag="BSU_39280" /old_locus_tag="BSU39280" /label="yxxE gene" downshifts complement(3687127) /Source="Nicolas_upshifts" /id="D2040" /incds=0 /nref=137 /ntot=221 /MaxReadThrough="3.99098" /MaxDrop="5.76651" /score="24.0715465" /energy="-21.3" /TU="U3101,U3102" /idTUdmin="U3101" /TUdmin="-3718" /isTUend="FALSE" /label="downshifts" CDS complement(3687458..3687901) /gene="rtbE" /locus_tag="BSU_39290" /old_locus_tag="BSU39290" /function="17: Mobile and extrachromosomal element functions" /experiment="publication(s) with functional evidences, PMID:22200572" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22200572; Product type f: factor" /codon_start=1 /transl_table=11 /product="antitoxin factor of the RttD-RttE toxin-antitoxin system" /protein_id="NP_391808.1" /db_xref="EnsemblGenomes-Gn:BSU39290" /db_xref="EnsemblGenomes-Tr:CAB15965" /db_xref="InterPro:IPR018958" /db_xref="SubtiList:BG11070" /db_xref="UniProtKB/Swiss-Prot:P40737" /translation="MSYNFIKSNKENDFYPVNQSEIEEVEKNLNLKLPSELVNFYLEV GYGFIKGSEFNTNRILDPYSVRDFRLRINDFEFYPDIEIYDEFENDKLIFFEGSESAL MSIELNDNNKNPIYYYDIQIATSLTEFLRKIEENDQYYLDLLDDE*" /label="rtbE CDS" gene complement(3687458..3687901) /gene="rtbE" /locus_tag="BSU_39290" /old_locus_tag="BSU39290" /label="rtbE gene" CDS complement(3687898..3689607) /gene="rtbD" /locus_tag="BSU_39300" /old_locus_tag="BSU39300" /function="17: Mobile and extrachromosomal element functions" /experiment="publication(s) with functional evidences, PMID:22200572" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22200572; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ribonuclease toxin of the RtbD-RtbE toxin-antitoxin system" /protein_id="NP_391809.2" /db_xref="EnsemblGenomes-Gn:BSU39300" /db_xref="EnsemblGenomes-Tr:CAB15966" /db_xref="GOA:P42296" /db_xref="InterPro:IPR003615" /db_xref="InterPro:IPR006829" /db_xref="InterPro:IPR027797" /db_xref="SubtiList:BG11133" /db_xref="UniProtKB/Swiss-Prot:P42296" /translation="MKTLDVHALHEGIQHTIEKLDKQKQQLEKLEKSVEHLAGMKDAL KGKGGDAIRTFYEECHKPFLLFFGIFIDEYKKVLKQTQHAISSVESNSHGMIAEAFLS HDARHGVKHAREVTEQLTDAVNRQTSAIDHIVSLPTVNDSFFRMETEQAERLISDTLN KLFQFDGQQTQALEAAKSDFQTMKKYIDQLETMYTGPKIEITGYKSGSILKSQEEENI NQIFGAINPQMKQADDSPMEMMLKKLAENEKSKVDSVVKTGDSKKVSKNIIVINGKVY NTSEHREHIKTDFSNAEVKQVVYNDTLYNVYISGNDMKLEPVVSLSDIKVDENGYVKI LETAVELTGVYDLFKAATGRDPVSGEKVTGKDRVVASINSVPFAKIAKLEKLIDINKL INNGKKAKKASEVKNVAKDKGKIANDVSGSANKINSDLIKKYARDIEQRTGRELPKNQ IDKLKEALRNKEYKKMSPIETAKHRTKFDKVKNKVIKEWEENTGQKWPVYKENVVSEK TGKIIRKKGDKYDAHHIIENTFGGEHEWWNMHPAKFPNEHQAGIHGTGSPANELFKGG KKK*" /label="rtbD CDS" gene complement(3687898..3689607) /gene="rtbD" /locus_tag="BSU_39300" /old_locus_tag="BSU39300" /label="rtbD gene" misc_feature complement(3688769..3688788) /Source="Nicolas_upshift_promotors" /id="U3101" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.551448551448551" /psig="0.994005994005994" /xcortree=1873 /SigmaFactorBS="aacgggtgattctaaaaaggtaagtaaaaatatcatcgttat caatggtAAAGTGTATAATACGAGTGAacatagagaacatataaaaactgatttctca a" /listShort="yxxD, yxxE, S1514, S1513, bglP, bglH" /listLong="yxiE" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3688777) /Source="Nicolas_upshifts" /id="U3101" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.551448551448551" /psig="0.994005994005994" /xcortree=1873 /SigmaFactorBS="aacgggtgattctaaaaaggtaagtaaaaatatcatcgttat caatggtAAAGTGTATAATACGAGTGAacatagagaacatataaaaactgatttctca a" /listShort="yxxD, yxxE, S1514, S1513, bglP, bglH" /listLong="yxiE" /label="upshifts" CDS complement(3689627..3689896) /gene="yxiC" /locus_tag="BSU_39310" /old_locus_tag="BSU39310" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391810.1" /db_xref="EnsemblGenomes-Gn:BSU39310" /db_xref="EnsemblGenomes-Tr:CAB15967" /db_xref="InterPro:IPR020315" /db_xref="SubtiList:BG11132" /db_xref="UniProtKB/Swiss-Prot:P42295" /translation="MAQEIKMVYDTVKQGLSQLKNSAELKSSLPGHLSGRNHLNVVKS IEQLNKDIKELTEAYASVLAKHIAQTESAVNAMKETDENISSSMK*" /label="yxiC CDS" gene complement(3689627..3689896) /gene="yxiC" /locus_tag="BSU_39310" /old_locus_tag="BSU39310" /label="yxiC gene" CDS complement(3689908..3690273) /gene="yxiB" /locus_tag="BSU_39320" /old_locus_tag="BSU39320" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391811.1" /db_xref="EnsemblGenomes-Gn:BSU39320" /db_xref="EnsemblGenomes-Tr:CAB15968" /db_xref="InterPro:IPR031681" /db_xref="SubtiList:BG11131" /db_xref="UniProtKB/Swiss-Prot:P42294" /translation="MHSEMLLHSVKADLHEKQEQIHQLKRVLHEIRQIKHDFSEAQHL IHRPHLNREAWRGTHAERFEDIREGMNKAYQQIKSDQVSGIIESIEGKIHSLEGDVYS IRRQITRIEHEIEKEKHKK*" /label="yxiB CDS" gene complement(3689908..3690273) /gene="yxiB" /locus_tag="BSU_39320" /old_locus_tag="BSU39320" /label="yxiB gene" S_feature complement(3690274..3690339) /Source="Nicolas_S_feature" /locus_tag="new_4039160_4039225_c" /HighExp="T-1.40H, T-3.40H, T2.30H, T-2.40H, T-0.40H, T1.0H, T-1.10H, T-5.40H, T3.30H, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1515" promotor_-10 complement(3690326..3690345) /Source="Nicolas_upshift_promotors" /id="U3102" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.694305694305694" /psig="0.997002997002997" /xcortree=2983 /SigmaFactorBS="ccagttctatacctctcaagacaatcctttttacctATTTat ccaatatgacccATCATGTAATATGAAAATAGtctgtattgtaaagaatttacacagt t" /listShort="S1515, yxiB, yxiC, yxiD, yxxD, yxxE, S1514, S1513, bglP, bglH, yxiE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3690339) /Source="Nicolas_upshifts" /id="U3102" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.694305694305694" /psig="0.997002997002997" /xcortree=2983 /SigmaFactorBS="ccagttctatacctctcaagacaatcctttttacctATTTat ccaatatgacccATCATGTAATATGAAAATAGtctgtattgtaaagaatttacacagt t" /listShort="S1515, yxiB, yxiC, yxiD, yxxD, yxxE, S1514, S1513, bglP, bglH, yxiE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3690360..3690363) /Source="Nicolas_upshift_promotors" /id="U3102" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.694305694305694" /psig="0.997002997002997" /xcortree=2983 /SigmaFactorBS="ccagttctatacctctcaagacaatcctttttacctATTTat ccaatatgacccATCATGTAATATGAAAATAGtctgtattgtaaagaatttacacagt t" /listShort="S1515, yxiB, yxiC, yxiD, yxxD, yxxE, S1514, S1513, bglP, bglH, yxiE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3690580..3691989) /gene="abnB" /locus_tag="BSU_39330" /old_locus_tag="BSU39330" /EC_number="3.2.1.99" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14973026, 18408032, 18607095, 20883454" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14973026, 18408032, 18607095, 20883454; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="arabinan endo-1,5-alpha-L-arabinosidase ([Ca(2+)-dependent]" /protein_id="NP_391812.2" /db_xref="EnsemblGenomes-Gn:BSU39330" /db_xref="EnsemblGenomes-Tr:CAB15969" /db_xref="GOA:P42293" /db_xref="InterPro:IPR006710" /db_xref="InterPro:IPR023296" /db_xref="InterPro:IPR032291" /db_xref="PDB:2X8F" /db_xref="PDB:2X8S" /db_xref="PDB:2X8T" /db_xref="PDB:4COT" /db_xref="SubtiList:BG11130" /db_xref="UniProtKB/Swiss-Prot:P42293" /translation="MFNRLFRVCFLAALIMAFTLPNSVYAQKPIFKEVSVHDPSIIET NGTFYVFGSHLASAKSNDLMQWQQLTTSVSNDNPLIPNVYEELKETFEWAQSDTLWAA DVTQLADGKYYMYYNACRGDSPRSAMGVAVADNIEGPYKNKGIFLKSGMEGTSSDGTP YDATKHPNVVDPHTFFDKDGKLWMVYGSYSGGIFILEMNPKTGFPLPGQGYGKKLLGG NHSRIEGPYVLYNPDTQYYYLYLSYGGLDATGGYNIRVARSKKPDGPYYDAEGNPMLD VRGKGGTFFDDRSIEPYGVKLMGSYTFETENEKGTGYVSPGHNSAYYDEKTGRSYLIF HTRFPGRGEEHEVRVHQLFMNKDGWPVAAPYRYAGETLKEVKQKDITGTYKLIQHGKD ISADIKQTINIQLNKNHTISGEMTGTWRKTGKNTADITLAGKKYNGVFLRQWDSVREK NVMTFSVLNTSGEAVWGSK*" /label="abnB CDS" gene complement(3690580..3691989) /gene="abnB" /locus_tag="BSU_39330" /old_locus_tag="BSU39330" /label="abnB gene" downshifts complement(3690603) /Source="Nicolas_upshifts" /id="D2041" /incds=0 /nref=2 /ntot=38 /MaxReadThrough="0.825980000000001" /MaxDrop="3.49689" /score="16.962389" /energy="-7.9" /TU="NA" /idTUdmin="U3101" /TUdmin="-7194" /isTUend="FALSE" /label="downshifts" S_feature complement(3691990..3692099) /Source="Nicolas_S_feature" /locus_tag="new_4040876_4040985_c" /HighExp="S2, T2.30H, BC, T2.0H, M9-stat, T3.0H, T3.30H, T4.0H, S1, T1.30H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1516" CDS complement(3692123..3692287) /gene="yxzL" /locus_tag="BSU_39339" /old_locus_tag="BSU39339" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="YP_003097797.1" /db_xref="EnsemblGenomes-Gn:BSU39339" /db_xref="EnsemblGenomes-Tr:CAX52712" /db_xref="UniProtKB/Swiss-Prot:C0H3T6" /translation="MAVSQLMQNLTKQLLHVRERKTDVMQEGETAKELNYEGEDMQAT SSAQNRQTSV*" /label="yxzL CDS" gene complement(3692123..3692287) /gene="yxzL" /locus_tag="BSU_39339" /old_locus_tag="BSU39339" /label="yxzL gene" promotor_-10 complement(3692172..3692190) /Source="Nicolas_upshift_promotors" /id="U3103" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=497 /SigmaFactorBS="tattacatgtacgcgaaagaaaaacagacgtgatgcaaGAAG GAGAAacagcaaaagAGTTGAACTATGAAGGAGAggatatgcaagcaacaagttctgc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3692187) /Source="Nicolas_upshifts" /id="U3103" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=497 /SigmaFactorBS="tattacatgtacgcgaaagaaaaacagacgtgatgcaaGAAG GAGAAacagcaaaagAGTTGAACTATGAAGGAGAggatatgcaagcaacaagttctgc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3692201..3692209) /Source="Nicolas_upshift_promotors" /id="U3103" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.974025974025974" /psig="0.974025974025974" /xcortree=497 /SigmaFactorBS="tattacatgtacgcgaaagaaaaacagacgtgatgcaaGAAG GAGAAacagcaaaagAGTTGAACTATGAAGGAGAggatatgcaagcaacaagttctgc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3692479..3692498) /Source="Nicolas_upshift_promotors" /id="U3104" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.440559440559441" /psig=1 /xcortree=2012 /SigmaFactorBS="attaattggttcagcagcagaagtcaaaaggttttttTATAG TCTttaacaagttagATTGCTATTGTAATAGCGTGacgcagaaagcagaacaggtttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3692495) /Source="Nicolas_upshifts" /id="U3104" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.440559440559441" /psig=1 /xcortree=2012 /SigmaFactorBS="attaattggttcagcagcagaagtcaaaaggttttttTATAG TCTttaacaagttagATTGCTATTGTAATAGCGTGacgcagaaagcagaacaggtttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3692511..3692518) /Source="Nicolas_upshift_promotors" /id="U3104" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.440559440559441" /psig=1 /xcortree=2012 /SigmaFactorBS="attaattggttcagcagcagaagtcaaaaggttttttTATAG TCTttaacaagttagATTGCTATTGTAATAGCGTGacgcagaaagcagaacaggtttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3692527..3692534 /Source="Nicolas_upshift_promotors" /id="U3105" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=495 /SigmaFactorBS="tagcaatctaacttgttaaagactataaaaaaaccTTTTGAC TtctgctgctgaaccAATTAATATAATACTCAGTTaatagttatcagaatttttagga a" /listShort="hutP, hutH, hutU, hutI, hutG, S1517, hutM" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3692549..3692568 /Source="Nicolas_upshift_promotors" /id="U3105" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=495 /SigmaFactorBS="tagcaatctaacttgttaaagactataaaaaaaccTTTTGAC TtctgctgctgaaccAATTAATATAATACTCAGTTaatagttatcagaatttttagga a" /listShort="hutP, hutH, hutU, hutI, hutG, S1517, hutM" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3692552 /Source="Nicolas_upshifts" /id="U3105" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.586413586413586" /psig=1 /xcortree=495 /SigmaFactorBS="tagcaatctaacttgttaaagactataaaaaaaccTTTTGAC TtctgctgctgaaccAATTAATATAATACTCAGTTaatagttatcagaatttttagga a" /listShort="hutP, hutH, hutU, hutI, hutG, S1517, hutM" /GFF_Attribute="listLong" /label="upshifts" CDS 3692606..3693052 /gene="hutP" /locus_tag="BSU_39340" /old_locus_tag="BSU39340" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15758992, 16192572, 16427271, 17395359, 18445631, 23748184, 24650662" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15758992, 16192572, 16427271, 17395359, 18445631, 23748184, 24650662; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional antiterminator" /protein_id="NP_391813.2" /db_xref="EnsemblGenomes-Gn:BSU39340" /db_xref="EnsemblGenomes-Tr:CAB15970" /db_xref="GOA:P10943" /db_xref="InterPro:IPR015111" /db_xref="InterPro:IPR023552" /db_xref="InterPro:IPR036482" /db_xref="PDB:1VEA" /db_xref="PDB:1WMQ" /db_xref="PDB:1WPS" /db_xref="PDB:1WPT" /db_xref="PDB:1WPU" /db_xref="PDB:1WPV" /db_xref="PDB:1WRN" /db_xref="PDB:1WRO" /db_xref="PDB:1WRQ" /db_xref="PDB:3BOY" /db_xref="PDB:4H4L" /db_xref="SubtiList:BG10666" /db_xref="UniProtKB/Swiss-Prot:P10943" /translation="MTLHKERRIGRLSVLLLLNEAEESTQVEELERDGWKVCLGKVGS MDAHKVVAAIETASKKSGVIQSEGYRESHALYHATMEALHGVTRGEMLLGSLLRTVGL RFAVLRGNPYESEAEGDWIAVSLYGTIGAPIKGLEHETFGVGINHI*" /label="hutP CDS" gene 3692606..3693052 /gene="hutP" /locus_tag="BSU_39340" /old_locus_tag="BSU39340" /label="hutP gene" downshifts 3693057 /Source="Nicolas_upshifts" /id="D2042" /incds=0 /nref=157 /ntot=226 /MaxReadThrough="6.10706" /MaxDrop="5.43744" /score="3.19376411" /energy="-17.8" /TU="U3105" /idTUdmin="U3105" /TUdmin="-7018" /isTUend="FALSE" /label="downshifts" CDS 3693165..3694691 /gene="hutH" /locus_tag="BSU_39350" /old_locus_tag="BSU39350" /EC_number="4.3.1.3" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 9535092, 10220322, 17395359; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="histidine ammonia-lyase (histidase)" /protein_id="NP_391814.1" /db_xref="EnsemblGenomes-Gn:BSU39350" /db_xref="EnsemblGenomes-Tr:CAB15971" /db_xref="GOA:P10944" /db_xref="InterPro:IPR001106" /db_xref="InterPro:IPR005921" /db_xref="InterPro:IPR008948" /db_xref="InterPro:IPR022313" /db_xref="InterPro:IPR024083" /db_xref="SubtiList:BG10667" /db_xref="UniProtKB/Swiss-Prot:P10944" /translation="MVTLDGSSLTTADVARVLFDFEEAAASEESMERVKKSRAAVERI VRDEKTIYGINTGFGKFSDVLIQKEDSAALQLNLILSHACGVGDPFPECVSRAMLLLR ANALLKGFSGVRAELIEQLLAFLNKRVHPVIPQQGSLGASGDLAPLSHLALALIGQGE VFFEGERMPAMTGLKKAGIQPVTLTSKEGLALINGTQAMTAMGVVAYIEAEKLAYQTE RIASLTIEGLQGIIDAFDEDIHLARGYQEQIDVAERIRFYLSDSGLTTSQGELRVQDA YSLRCIPQVHGATWQTLGYVKEKLEIEMNAATDNPLIFNDGDKVISGGNFHGQPIAFA MDFLKIAISELANIAERRIERLVNPQLNDLPPFLSPHPGLQSGAMIMQYAAASLVSEN KTLAHPASVDSIPSSANQEDHVSMGTIAARHAYQVIANTRRVIAIEAICALQAVEYRG IEHAASYTKQLFQEMRKVVPSIQQDRVFSYDIERLTDWLKKESLIPDHQNKELRGMNI *" /label="hutH CDS" gene 3693165..3694691 /gene="hutH" /locus_tag="BSU_39350" /old_locus_tag="BSU39350" /label="hutH gene" CDS 3694688..3696346 /gene="hutU" /locus_tag="BSU_39360" /old_locus_tag="BSU39360" /EC_number="4.2.1.49" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15313616, 17395359, 22933560; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="urocanase" /protein_id="NP_391815.1" /db_xref="EnsemblGenomes-Gn:BSU39360" /db_xref="EnsemblGenomes-Tr:CAB15972" /db_xref="GOA:P25503" /db_xref="InterPro:IPR023636" /db_xref="InterPro:IPR023637" /db_xref="InterPro:IPR035085" /db_xref="InterPro:IPR035400" /db_xref="InterPro:IPR035401" /db_xref="InterPro:IPR036190" /db_xref="PDB:2FKN" /db_xref="SubtiList:BG10668" /db_xref="UniProtKB/Swiss-Prot:P25503" /translation="MTDVKKSIRANRGTELECLGWEQEAVLRMLRNNLDPEVAEKPED LIVYGGIGKAARDWDAFHAIEHSLKTLKNDETLLVQSGKPVGMFRTHPQAPRVLLANS VLVPKWADWEHFHELEKKGLMMYGQMTAGSWIYIGSQGILQGTYETFAELARQHFGGS LKGTLTLTAGLGGMGGAQPLSVTMNEGVVIAVEVDEKRIDKRIETKYCDRKTASIEEA LAWAEEAKLAGKPLSIALLGNAAEVHHTLLNRGVKIDIVTDQTSAHDPLIGYVPEGYS LDEADRLRQDTPELYVRLAKQSMKKHVEAMLAFQQKGSIVFDYGNNIRQVAKDEGLEN AFDFPGFVPAYIRPLFCEGKGPFRWAALSGDPADIYRTDALLKELFPTNKALHRWIDM AQEKVTFQGLPSRICWLGYGERKKMGLAINELVRTGELKAPVVIGRDHLDCGSVASPN RETEAMKDGSDAVGDWAVLNALVNTAAGASWVSFHHGGGVGMGYSLHAGMVAVADGSE LADERLARVLTSDPGMGIIRHADAGYERAVEVAKEQDIIVPMQK*" /label="hutU CDS" gene 3694688..3696346 /gene="hutU" /locus_tag="BSU_39360" /old_locus_tag="BSU39360" /label="hutU gene" CDS 3696359..3697624 /gene="hutI" /locus_tag="BSU_39370" /old_locus_tag="BSU39370" /EC_number="3.5.2.7" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:16990261, 17395359, 18296777" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16990261, 17395359, 18296777; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="imidazolone-5-propionate hydrolase" /protein_id="NP_391816.1" /db_xref="EnsemblGenomes-Gn:BSU39370" /db_xref="EnsemblGenomes-Tr:CAB15973" /db_xref="GOA:P42084" /db_xref="InterPro:IPR005920" /db_xref="InterPro:IPR006680" /db_xref="InterPro:IPR011059" /db_xref="InterPro:IPR032466" /db_xref="PDB:2BB0" /db_xref="PDB:2G3F" /db_xref="SubtiList:BG11100" /db_xref="UniProtKB/Swiss-Prot:P42084" /translation="MPKQIDTILINIGQLLTMESSGPRAGKSMQDLHVIEDAVVGIHE QKIVFAGQKGAEAGYEADEIIDCSGRLVTPGLVDPHTHLVFGGSREKEMNLKLQGISY LDILAQGGGILSTVKDTRAASEEELLQKAHFHLQRMLSYGTTTAEVKSGYGLEKETEL KQLRVAKKLHESQPVDLVSTFMGAHAIPPEYQNDPDDFLDQMLSLLPEIKEQELASFA DIFTETGVFTVSQSRRYLQKAAEAGFGLKIHADEIDPLGGAELAGKLKAVSADHLVGT SDEGIKKLAEAGTIAVLLPGTTFYLGKSTYARARAMIDEGVCVSLATDFNPGSSPTEN IQLIMSIAALHLKMTAEEIWHAVTVNAAYAIGKGEEAGQLKAGRSADLVIWQAPNYMY IPYHYGVNHVHQVMKNGTIVVNREGAILG*" /label="hutI CDS" gene 3696359..3697624 /gene="hutI" /locus_tag="BSU_39370" /old_locus_tag="BSU39370" /label="hutI gene" CDS 3697617..3698576 /gene="hutG" /locus_tag="BSU_39380" /old_locus_tag="BSU39380" /EC_number="3.5.3.8" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 10931887, 15355972, 17395359; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="formiminoglutamate hydrolase" /protein_id="NP_391817.1" /db_xref="EnsemblGenomes-Gn:BSU39380" /db_xref="EnsemblGenomes-Tr:CAB15974" /db_xref="GOA:P42068" /db_xref="InterPro:IPR005923" /db_xref="InterPro:IPR006035" /db_xref="InterPro:IPR020855" /db_xref="InterPro:IPR023696" /db_xref="PDB:3M1R" /db_xref="SubtiList:BG11099" /db_xref="UniProtKB/Swiss-Prot:P42068" /translation="MDKYPFLREAGSSFKDRDVTKMSDLIATWDGQDIKGPALIGVPL SKSSISHSGASFAPGTIRQALKHSSAYSAELGEHVVSELLYDLGDIDIHVTDIVKSHH HIFQTMHALLSDHPDWVPLILGGDNSISYSTIKAIAQTKGTTAVIQFDAHHDVRNTED GGPTNGTPFRRLLDEEIIEGQHLIQLGIREFSNSQAYEAYAKKHNVNIHTMDMIREKG LIPTIKEILPVVQDKTDFIFISVDMDVLDQSHAPGCPAIGPGGLYTDELLEAVKYIAQ QPNVAGIEIVEVDPTLDFRDMTSRAAAHVLLHALKGMKLSPFK*" /label="hutG CDS" gene 3697617..3698576 /gene="hutG" /locus_tag="BSU_39380" /old_locus_tag="BSU39380" /label="hutG gene" S_feature 3698577..3698651 /Source="Nicolas_S_feature" /locus_tag="new_4047463_4047537" /HighExp="Sw, BC, T3.30H, T4.0H, T5.0H, T3.0H, T2.30H, S8, M9-stat, T2.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1517" CDS 3698652..3700079 /gene="hutM" /locus_tag="BSU_39390" /old_locus_tag="BSU39390" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 7704263, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="histidine degradation metabolites permease" /protein_id="NP_391818.2" /db_xref="EnsemblGenomes-Gn:BSU39390" /db_xref="EnsemblGenomes-Tr:CAB15975" /db_xref="GOA:P42087" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG11101" /db_xref="UniProtKB/Swiss-Prot:P42087" /translation="MNLQENSSQQLKRTMKSRHLFMISLGGVIGTGLFLSTGYTLHQA GPGGTILAYVIGGLMMYLVMQCLGELSVAMPVTGSFQKYATTFIGPSTGFMVGIMYWI NWVVTVGSEFTASGILMQRWFPDSSVWMWSAIFAALLFICNAFSVKLFAETEFWFSSV KIVTIILFIILGGAAMFGLISLNGTADAPMLSNFTDHGGLFPNGFLAVFIAMISVSFA FSGTELIGVTAGESANPQKDIPRSIRNVAWRTVIFFIGAVFILSGLISWKDAGVIESP FVAVFAEIGIPYAADIMNFVILTALLSVANSGLYASTRMMWSLANENMISSRFKKVTS KGIPLNALMISMAVSCLSLVSSIVAPGTVYVVMVAIAGFAGVVVWMSIALSQLLFRKR FLKKGGDVKDLTFRTPLYPLMPIAALLLCSASCIGLAFDPNQRIALFCGVPCIILCYL IYHFKRNVTKAKKISQEEYPADHIL*" /label="hutM CDS" gene 3698652..3700079 /gene="hutM" /locus_tag="BSU_39390" /old_locus_tag="BSU39390" /label="hutM gene" downshifts 3700075 /Source="Nicolas_upshifts" /id="D2043" /incds=0 /nref=11 /ntot=31 /MaxReadThrough="0.7432" /MaxDrop="6.18816" /score="8.21347356" /energy="-11.7" /TU="NA" /idTUdmin="U3105" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3700123..3701424) /gene="pdp" /locus_tag="BSU_39400" /old_locus_tag="BSU39400" /EC_number="2.4.2.2" /EC_number="2.4.2.3" /EC_number="2.4.2.4" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8550462, 10074062, 11065368, 15530033, 16469506, 21707079" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8550462, 10074062, 11065368, 15530033, 16469506, 21707079; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="pyrimidine-nucleoside phosphorylase" /protein_id="NP_391819.2" /db_xref="EnsemblGenomes-Gn:BSU39400" /db_xref="EnsemblGenomes-Tr:CAB15976" /db_xref="GOA:P39142" /db_xref="InterPro:IPR000053" /db_xref="InterPro:IPR000312" /db_xref="InterPro:IPR013102" /db_xref="InterPro:IPR017459" /db_xref="InterPro:IPR017872" /db_xref="InterPro:IPR018090" /db_xref="InterPro:IPR035902" /db_xref="InterPro:IPR036320" /db_xref="InterPro:IPR036566" /db_xref="PDB:5EP8" /db_xref="SubtiList:BG10985" /db_xref="UniProtKB/Swiss-Prot:P39142" /translation="MRMVDIIIKKQNGKELTTEEIQFFVNGYTDGSIPDYQASALAMA IFFQDMSDRERADLTMAMVNSGETIDLSAIEGIKVDKHSTGGVGDTTTLVLAPLVAAL DVPVAKMSGRGLGHTGGTIDKLEAIMGFHVELTKDEFIKLVNRDKVAVIGQSGNLTPA DKKLYALRDVTGTVNSIPLIASSIMSKKIAAGADAIVLDVKTGAGAFMKTEEDAAELA KAMVRIGNNVGRQTMAVISDMSQPLGFAIGNALEVKEAIDTLKGEGPEDLHELVLTLG SQMVVLAKKADTLDEARAKLEEVMKNGKALEKFKDFLKNQGGDSSIVDDPSKLPQAAY QIDVPAKEAGVVSEIVADEIGVAAMLLGAGRATKEDEIDLAVGIMLRKKVGDKVEKGE PLVTLYANRENVDEVIAKVYDNIRIAAEAKAPKLIHTLITE*" /label="pdp CDS" gene complement(3700123..3701424) /gene="pdp" /locus_tag="BSU_39400" /old_locus_tag="BSU39400" /label="pdp gene" downshifts complement(3700140) /Source="Nicolas_upshifts" /id="D2044" /incds=0 /nref=122 /ntot=224 /MaxReadThrough="1.27022" /MaxDrop="5.60021" /score="14.0361257" /energy="-13.1" /TU="NA" /idTUdmin="U3107" /TUdmin="-11" /isTUend="TRUE" /label="downshifts" CDS complement(3701454..3702635) /gene="nupC" /locus_tag="BSU_39410" /old_locus_tag="BSU39410" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:8550462, 11065368, 12591866, 15849754, 16850406, 25890046" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8550462, 11065368, 12591866, 15849754, 16850406, 25890046; Product type t : transporter" /codon_start=1 /transl_table=11 /product="pyrimidine-nucleoside Na+(H+) cotransporter" /protein_id="NP_391820.2" /db_xref="EnsemblGenomes-Gn:BSU39410" /db_xref="EnsemblGenomes-Tr:CAB15977" /db_xref="GOA:P39141" /db_xref="InterPro:IPR002668" /db_xref="InterPro:IPR008276" /db_xref="InterPro:IPR011657" /db_xref="InterPro:IPR018270" /db_xref="SubtiList:BG10984" /db_xref="UniProtKB/Swiss-Prot:P39141" /translation="MKYLIGIIGLIVFLGLAWIASSGKKRIKIRPIVVMLILQFILGY ILLNTGIGNFLVGGFAKGFGYLLEYAAEGINFVFGGLVNADQTTFFMNVLLPIVFISA LIGILQKWKVLPFIIRYIGLALSKVNGMGRLESYNAVASAILGQSEVFISLKKELGLL NQQRLYTLCASAMSTVSMSIVGAYMTMLKPEYVVTALVLNLFGGFIIASIINPYEVAK EEDMLRVEEEEKQSFFEVLGEYILDGFKVAVVVAAMLIGFVAIIALINGIFNAVFGIS FQGILGYVFAPFAFLVGIPWNEAVNAGSIMATKMVSNEFVAMTSLTQNGFHFSGRTTA IVSVFLVSFANFSSIGIIAGAVKGLNEKQGNVVARFGLKLLYGATLVSFLSAAIVGLI Y*" /label="nupC CDS" gene complement(3701454..3702635) /gene="nupC" /locus_tag="BSU_39410" /old_locus_tag="BSU39410" /label="nupC gene" S_feature complement(3702636..3702715) /Source="Nicolas_S_feature" /locus_tag="new_4051522_4051601_c" /HighExp="G150, G135, Oxctl, G180, Mt0, M40t45, Lbtran, M0t90, M40t90, S0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1518" CDS complement(3702716..3703387) /gene="deoC" /locus_tag="BSU_39420" /old_locus_tag="BSU39420" /EC_number="4.1.2.4" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8550462, 10074062, 11065368, 27033207" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8550462, 10074062, 11065368, 27033207; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="deoxyribose-phosphate aldolase" /protein_id="NP_391821.2" /db_xref="EnsemblGenomes-Gn:BSU39420" /db_xref="EnsemblGenomes-Tr:CAB15978" /db_xref="GOA:P39121" /db_xref="InterPro:IPR002915" /db_xref="InterPro:IPR011343" /db_xref="InterPro:IPR013785" /db_xref="InterPro:IPR028581" /db_xref="SubtiList:BG10983" /db_xref="UniProtKB/Swiss-Prot:P39121" /translation="MSLANIIDHTALKPHTQKADILKLIEEAKTYKFASVCVNPTWVE LAAKELKGTGVDVCTVIGFPLGANTTETKAFETKDAISKGATEVDMVINIAALKDKED DVVEADIRGVVEAVAGKALVKVIIETCLLTDEEKERACRLAVSAGADFVKTSTGFSTG GATKEDIALMRKTVGPDIGVKASGGVRTKEDVDTMVEAGASRIGASAGVSIVKGENAS GGDNY*" /label="deoC CDS" gene complement(3702716..3703387) /gene="deoC" /locus_tag="BSU_39420" /old_locus_tag="BSU39420" /label="deoC gene" promotor_-35 3703336..3703339 /Source="Nicolas_upshift_promotors" /id="U3106" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.343656343656344" /psig="0.972027972027972" /xcortree=1858 /SigmaFactorBS="tgtatgttttcgcttcttcaattagttttagaatgtccgctt TTTGtgtatgcggtttcaaAGCTGTATGATCAATTATGTtggctaatgacatccttcg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3703354 /Source="Nicolas_upshifts" /id="U3106" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.343656343656344" /psig="0.972027972027972" /xcortree=1858 /SigmaFactorBS="tgtatgttttcgcttcttcaattagttttagaatgtccgctt TTTGtgtatgcggtttcaaAGCTGTATGATCAATTATGTtggctaatgacatccttcg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3703355..3703374 /Source="Nicolas_upshift_promotors" /id="U3106" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.343656343656344" /psig="0.972027972027972" /xcortree=1858 /SigmaFactorBS="tgtatgttttcgcttcttcaattagttttagaatgtccgctt TTTGtgtatgcggtttcaaAGCTGTATGATCAATTATGTtggctaatgacatccttcg c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(3703415..3703434) /Source="Nicolas_upshift_promotors" /id="U3107" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig=1 /xcortree=1555 /SigmaFactorBS="cgttcaaacctttcattgaacaaaatttcaattacCAATTTA CatatgttcaaaagTCGGTTATGCTAAAAAATATcttaacaaaaaaggaagtgtgcga a" /listShort="deoC, S1518, nupC, pdp" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3703430) /Source="Nicolas_upshifts" /id="U3107" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig=1 /xcortree=1555 /SigmaFactorBS="cgttcaaacctttcattgaacaaaatttcaattacCAATTTA CatatgttcaaaagTCGGTTATGCTAAAAAATATcttaacaaaaaaggaagtgtgcga a" /listShort="deoC, S1518, nupC, pdp" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3703448..3703455) /Source="Nicolas_upshift_promotors" /id="U3107" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.625374625374625" /psig=1 /xcortree=1555 /SigmaFactorBS="cgttcaaacctttcattgaacaaaatttcaattacCAATTTA CatatgttcaaaagTCGGTTATGCTAAAAAATATcttaacaaaaaaggaagtgtgcga a" /listShort="deoC, S1518, nupC, pdp" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3703493..3704434) /gene="deoR" /locus_tag="BSU_39430" /old_locus_tag="BSU39430" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:8550462, 10074062, 10714997, 24863636" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8550462, 10074062, 10714997, 24863636; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of pyrmidine deoxyribonucleosides degradation (DeoR-dR5P)" /protein_id="NP_391822.1" /db_xref="EnsemblGenomes-Gn:BSU39430" /db_xref="EnsemblGenomes-Tr:CAB15979" /db_xref="GOA:P39140" /db_xref="InterPro:IPR007324" /db_xref="InterPro:IPR013324" /db_xref="PDB:4OQP" /db_xref="PDB:4OQQ" /db_xref="SubtiList:BG10982" /db_xref="UniProtKB/Swiss-Prot:P39140" /translation="MDREKQQLSIEAARLYYQSDYSQQQIAEQLNISRPTVSRLLQYA KEKGYVQIRVMDPFEDLDALGSILEEKYGLLEAHVVFSPTPDYAGITHDLSRYGAEYM HETVKDGDIVGVSWGTTMYQIAQNMQPKQVKGVEVVQLKGGISHSRVNTYSAETIQLF AEAFQTMPRYLPLPVVFDNADVKRMVEKDRHIERIIEMGKQANIALFTVGTVRDEALL FRLGYFNEEEKALLKKQAVGDICSRFFDAKGNICSSAINDRTIGVELQDLRLKERSIL VAGGSRKVSSIHGALTGKYANVLIIDQHTARALVNDL*" /label="deoR CDS" gene complement(3703493..3704434) /gene="deoR" /locus_tag="BSU_39430" /old_locus_tag="BSU39430" /label="deoR gene" promotor_-10 complement(3704479..3704498) /Source="Nicolas_upshift_promotors" /id="U3108" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.723276723276723" /psig="0.996003996003996" /xcortree=2323 /SigmaFactorBS="gagcgtttttcagtttcttagaaatcagGTGGatgaaagccg gcgccAGCCTGTATAATAAAAGCAAatcaaaagcagttttatcaggactgatccacag g" /listShort="deoR, deoC, S1518, nupC, pdp" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3704485) /Source="Nicolas_upshifts" /id="U3108" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.723276723276723" /psig="0.996003996003996" /xcortree=2323 /SigmaFactorBS="gagcgtttttcagtttcttagaaatcagGTGGatgaaagccg gcgccAGCCTGTATAATAAAAGCAAatcaaaagcagttttatcaggactgatccacag g" /listShort="deoR, deoC, S1518, nupC, pdp" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3704487..3704567) /Source="Nicolas_S_feature" /locus_tag="new_4053373_4053453_c" /HighExp="Etha, Diami, Salt, MG 10, Gly, MG 60, G180, GM 60, G135, dia5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.55204399999999998" /TUshortSig="SigB" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1519" promotor_-35 complement(3704514..3704517) /Source="Nicolas_upshift_promotors" /id="U3108" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.723276723276723" /psig="0.996003996003996" /xcortree=2323 /SigmaFactorBS="gagcgtttttcagtttcttagaaatcagGTGGatgaaagccg gcgccAGCCTGTATAATAAAAGCAAatcaaaagcagttttatcaggactgatccacag g" /listShort="deoR, deoC, S1518, nupC, pdp" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3704568..3705395) /gene="yxxB" /locus_tag="BSU_39440" /old_locus_tag="BSU39440" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10746760, 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_391823.2" /db_xref="EnsemblGenomes-Gn:BSU39440" /db_xref="EnsemblGenomes-Tr:CAB15980" /db_xref="GOA:P39139" /db_xref="InterPro:IPR009597" /db_xref="SubtiList:BG10981" /db_xref="UniProtKB/Swiss-Prot:P39139" /translation="MAVKDRYMSKIKQETKPWIKRFGRLGYFAFGGVFILLGVLAFMT AAGAGRAKDSSGALQTLSRMPYGSLLLFFIGIGLIGYVIWMVLSAIKDTEGHGNSRRG LSRRIGNFFSAAVYTSIAWNALRFVFGQGDGGTSEQTWSAYVLAQPFGQWLTGLTGAG FIVFAIVQFMKGVRAAFMKEFDTSKMNKQMICITKNTGRAGNIARAIIFSAIGYFLIK TAMTADPDDTRGFDGALAELAQQPHGKLILSILALGLILYGMYAIMKGIYQHMTWEK* " /label="yxxB CDS" gene complement(3704568..3705395) /gene="yxxB" /locus_tag="BSU_39440" /old_locus_tag="BSU39440" /label="yxxB gene" downshifts complement(3705367) /Source="Nicolas_upshifts" /id="D2045" /incds=0 /nref=6 /ntot=96 /MaxReadThrough="4.46865" /MaxDrop="3.48502" /score="14.6805498" /energy="-16" /TU="U3109,U3111" /idTUdmin="U3111" /TUdmin="-770" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3705420..3705438) /Source="Nicolas_upshift_promotors" /id="U3109" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=169 /SigmaFactorBS="aacgtatctcagccagccatagctgaggcaggagcTGTTTCA actttgttcaatcGGGAATGTTACAGTAAAGAtttctgtgaaagagggttggacacat g" /listShort="yxxB, S1519, deoR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3705433) /Source="Nicolas_upshifts" /id="U3109" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=169 /SigmaFactorBS="aacgtatctcagccagccatagctgaggcaggagcTGTTTCA actttgttcaatcGGGAATGTTACAGTAAAGAtttctgtgaaagagggttggacacat g" /listShort="yxxB, S1519, deoR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3705452..3705458) /Source="Nicolas_upshift_promotors" /id="U3109" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=169 /SigmaFactorBS="aacgtatctcagccagccatagctgaggcaggagcTGTTTCA actttgttcaatcGGGAATGTTACAGTAAAGAtttctgtgaaagagggttggacacat g" /listShort="yxxB, S1519, deoR" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3705468..3706580) /gene="yxeR" /locus_tag="BSU_39450" /old_locus_tag="BSU39450" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 1860825, 10746760, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ethanolamine permease" /protein_id="NP_391824.1" /db_xref="EnsemblGenomes-Gn:BSU39450" /db_xref="EnsemblGenomes-Tr:CAB15981" /db_xref="GOA:P54957" /db_xref="InterPro:IPR007441" /db_xref="SubtiList:BG11894" /db_xref="UniProtKB/Swiss-Prot:P54957" /translation="MTVNDAVVFILAAFLLWGAADYCLGNRWGLGERFADGFKAMGPL ALSMIGIVSLAPVLAAILIPIVAPFYTAIGADPSSFANTILAIDMGGYALAGEMAKDP QAGLFSWVFLGTMMGPAIVFTIPVALGIIEKEDHPYFAKGILIGLCTVPIGCLIGGLC AGFDIGMIGKNLLIPSLLSAVIAFGLWRYTDRMIQLFHLFGKAVSMVAIIGLAAVSVE TMTGIVLIPGMENVETGIQTTGTIAIALAGAFPMTAFITKTFKKPLQALGKCLHLDET ATAGLVTSLAHHIPMLASLKDMTPRGKVINVAFAVSGAFVLGSHLGFVAGMKKEMAAA MIIGKLAGGVTAAAAAAWMTPAQSAKQQKRISASHS*" /label="yxeR CDS" gene complement(3705468..3706580) /gene="yxeR" /locus_tag="BSU_39450" /old_locus_tag="BSU39450" /label="yxeR gene" CDS complement(3706650..3707987) /gene="yxeQ" /locus_tag="BSU_39460" /old_locus_tag="BSU39460" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12193636, 16513748, 16885442; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative catabolic enzyme" /protein_id="NP_391825.2" /db_xref="EnsemblGenomes-Gn:BSU39460" /db_xref="EnsemblGenomes-Tr:CAB15982" /db_xref="GOA:P54956" /db_xref="InterPro:IPR005656" /db_xref="InterPro:IPR036148" /db_xref="SubtiList:BG11893" /db_xref="UniProtKB/Swiss-Prot:P54956" /translation="MSKQGLTAGLAEAVRTSQPEHSVDAIHEAKKGLLDFTAASFAGR EDKGIQKLLRLIEDEGGRPLVPVIGQGKKAAPLQSAMLNGFIAHALDFDDVHSDVRGH PSAVIVPALIASAARGHDERLLGAYVVGVEVMARLGESIGSRHYEKGWHNTGTLGAIA AACAVGYAEELTQEELEKAIGFAATQSAGMRVQFGTEMKPLHAGLAAQAGLLAVKLAQ SEFGGSRTALDGETGFFSLYGDVEKAQHTLLNDWGAPWRIVQPGLWFKIYPFCSAAHH AADAVRQLISEETISAANTERIEVIFPPGGDAALTERSPKAGEEGRFSVEYVIALALH GHGLTVEHFSSQPIPNGVQTTMGRIQRVYDNAIQPAPHAVPKGRFTIVRAYLSDGRIC EARVDCPKGAPGNELSEEDIIEKLTLTVPQEKARRIITAVEKADIKEFLAHIE*" /label="yxeQ CDS" gene complement(3706650..3707987) /gene="yxeQ" /locus_tag="BSU_39460" /old_locus_tag="BSU39460" /label="yxeQ gene" CDS complement(3707984..3709126) /gene="sndB" /locus_tag="BSU_39470" /old_locus_tag="BSU39470" /EC_number="3.5.-.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12193636, 16513748, 16885442, 23944997, 28032445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12193636, 16513748, 16885442, 23944997, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="N-acetyl-sulfur-metabolite deacetylase" /protein_id="NP_391826.2" /db_xref="EnsemblGenomes-Gn:BSU39470" /db_xref="EnsemblGenomes-Tr:CAB15983" /db_xref="GOA:P54955" /db_xref="InterPro:IPR002933" /db_xref="InterPro:IPR011650" /db_xref="InterPro:IPR017439" /db_xref="InterPro:IPR033846" /db_xref="InterPro:IPR036264" /db_xref="PDB:1YSJ" /db_xref="SubtiList:BG11892" /db_xref="UniProtKB/Swiss-Prot:P54955" /translation="MADKAFHTRLINMRRDLHEHPELSFQEVETTKKIRRWLEEEQIE ILDVPQLKTGVIAEIKGREDGPVIAIRADIDALPIQEQTNLPFASKVDGTMHACGHDF HTASIIGTAMLLNQRRAELKGTVRFIFQPAEEIAAGARKVLEAGVLNGVSAIFGMHNK PDLPVGTIGVKEGPLMASVDRFEIVIKGKGGHAGIPNNSIDPIAAAGQIISGLQSVVS RNISSLQNAVVSITRVQAGTSWNVIPDQAEMEGTVRTFQKEARQAVPEHMRRVAEGIA AGYGAQAEFKWFPYLPSVQNDGTFLNAASEAAARLGYQTVHAEQSPGGEDFALYQEKI PGFFVWMGTNGTEEWHHPAFTLDEEALTVASQYFAELAVIVLETIK*" /label="sndB CDS" gene complement(3707984..3709126) /gene="sndB" /locus_tag="BSU_39470" /old_locus_tag="BSU39470" /label="sndB gene" CDS complement(3709143..3709892) /gene="yxeO" /locus_tag="BSU_39480" /old_locus_tag="BSU39480" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12193636, 16513748, 16885442, 25875741; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (ATP-binding protein)" /protein_id="NP_391827.1" /db_xref="EnsemblGenomes-Gn:BSU39480" /db_xref="EnsemblGenomes-Tr:CAB15984" /db_xref="GOA:P54954" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR030679" /db_xref="SubtiList:BG11891" /db_xref="UniProtKB/Swiss-Prot:P54954" /translation="MITVKNIRKAFKDLVVLDGIDLEVKRGEVVAIIGPSGSGKSTLL RCLNLLERPDQGLIEIGEAKLNAEKFTRKEAHRLRQQTAMVFQNYNLFKNKTALQNIT EALIVAQHKPRDEAKRIGMEILKQVGLEHKADSYPITMSGGQQQRIGIARALAVNPHA ILLDEPTSALDPELVTGVLQVIKSIAEKQTTMIIVTHEMAFAKEVADQVIFMADGHII EQGTPEELFDHPKNERTKRFIKQVGEPAELI*" /label="yxeO CDS" gene complement(3709143..3709892) /gene="yxeO" /locus_tag="BSU_39480" /old_locus_tag="BSU39480" /label="yxeO gene" CDS complement(3709905..3710579) /gene="yxeN" /locus_tag="BSU_39490" /old_locus_tag="BSU39490" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12193636, 15849754, 16513748, 16850406, 16885442; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative ABC transporter (permease)" /protein_id="NP_391828.1" /db_xref="EnsemblGenomes-Gn:BSU39490" /db_xref="EnsemblGenomes-Tr:CAB15985" /db_xref="GOA:P54953" /db_xref="InterPro:IPR000515" /db_xref="InterPro:IPR010065" /db_xref="InterPro:IPR035906" /db_xref="SubtiList:BG11890" /db_xref="UniProtKB/Swiss-Prot:P54953" /translation="MNTIDWEFMISAFPTLIQALPITLFMAIAAMIFAIIGGLILALI TKNKIPVLHQLSKLYISFFRGVPTLVQLFLIYYGLPQLFPEMSKMTALTAAIIGLSLK NAAYLAEIFRAALNSVDDGQLEACLSVGMTKFQAYRRIILPQAIRNAIPATGNTFIGL LKETSLAFTLGVMEMFAQGKMYASGNLKYFETYLAVAIVYWVLTIIYSILQDLFERAM SKPYRT*" /label="yxeN CDS" gene complement(3709905..3710579) /gene="yxeN" /locus_tag="BSU_39490" /old_locus_tag="BSU39490" /label="yxeN gene" CDS complement(3710602..3711396) /gene="yxeM" /locus_tag="BSU_39500" /old_locus_tag="BSU39500" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12193636, 16513748, 16885442; Product type lp: lipoprotein" /codon_start=1 /transl_table=11 /product="putative ABC transporter (binding lipoprotein)" /protein_id="NP_391829.1" /db_xref="EnsemblGenomes-Gn:BSU39500" /db_xref="EnsemblGenomes-Tr:CAB15986" /db_xref="GOA:P54952" /db_xref="InterPro:IPR001638" /db_xref="InterPro:IPR018313" /db_xref="SubtiList:BG11889" /db_xref="UniProtKB/Swiss-Prot:P54952" /translation="MKMKKWTVLVVAALLAVLSACGNGNSSSKEDDNVLHVGATGQSY PFAYKENGKLTGFDVEVMEAVAKKIDMKLDWKLLEFSGLMGELQTGKLDTISNQVAVT DERKETYNFTKPYAYAGTQIVVKKDNTDIKSVDDLKGKTVAAVLGSNHAKNLESKDPD KKINIKTYETQEGTLKDVAYGRVDAYVNSRTVLIAQIKKTGLPLKLAGDPIVYEQVAF PFAKDDAHDKLRKKVNKALDELRKDGTLKKLSEKYFNEDITVEQKH*" /label="yxeM CDS" gene complement(3710602..3711396) /gene="yxeM" /locus_tag="BSU_39500" /old_locus_tag="BSU39500" /label="yxeM gene" promotor_-35 3710968..3710977 /Source="Nicolas_upshift_promotors" /id="U3110" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1707 /SigmaFactorBS="gctttcaaggtttttcgcgtggtttgaaccgagaacggcTGC GACTGTCttgccttttaaaTCGTCTACTGATTTGAtgtctgtattgtcttttttgacg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3710989 /Source="Nicolas_upshifts" /id="U3110" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1707 /SigmaFactorBS="gctttcaaggtttttcgcgtggtttgaaccgagaacggcTGC GACTGTCttgccttttaaaTCGTCTACTGATTTGAtgtctgtattgtcttttttgacg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3710990..3711005 /Source="Nicolas_upshift_promotors" /id="U3110" /multdbtbs="-" /comp="M9" /sig="SigWXY" /pcomp="0.99000999000999" /psig="0.99000999000999" /xcortree=1707 /SigmaFactorBS="gctttcaaggtttttcgcgtggtttgaaccgagaacggcTGC GACTGTCttgccttttaaaTCGTCTACTGATTTGAtgtctgtattgtcttttttgacg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(3711421..3711918) /gene="snaB" /locus_tag="BSU_39510" /old_locus_tag="BSU39510" /EC_number="2.3.1.-" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:12193636, 16513748, 16885442, 23944997, 28032445" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12193636, 16513748, 16885442, 23944997, 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sulfur-containing aminoacid acetyltransferase" /protein_id="NP_391830.2" /db_xref="EnsemblGenomes-Gn:BSU39510" /db_xref="EnsemblGenomes-Tr:CAB15987" /db_xref="GOA:P54951" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG11888" /db_xref="UniProtKB/Swiss-Prot:P54951" /translation="MKPRYRLAVERDAEQLLELTLRAYEPIRKLGIRFAAAHADLDLV LKNIRENACYVMEEDGRIIATITLRMPWGKQPGPYGVPHIWWFAVDPDTGKKGIGTKL LQWLEETILRDTLKVPFVSLGTADKHPWLIEMYERKGYVRSGEQDLGKGHITVYMKKQ LRHDL*" /label="snaB CDS" gene complement(3711421..3711918) /gene="snaB" /locus_tag="BSU_39510" /old_locus_tag="BSU39510" /label="snaB gene" CDS complement(3711932..3713257) /gene="yxeK" /locus_tag="BSU_39520" /old_locus_tag="BSU39520" /EC_number="1.14.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 8892809, 12193636, 15294834, 16513748, 16885442, 23944997; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="putative monooxygenase" /protein_id="NP_391831.1" /db_xref="EnsemblGenomes-Gn:BSU39520" /db_xref="EnsemblGenomes-Tr:CAB15988" /db_xref="GOA:P54950" /db_xref="InterPro:IPR011251" /db_xref="InterPro:IPR016215" /db_xref="InterPro:IPR036661" /db_xref="SubtiList:BG11887" /db_xref="UniProtKB/Swiss-Prot:P54950" /translation="MTSKKKQIKLGVFLAGTGHHVASWRHPDAPSDASMNLDYFKELA KTAERGKLDMLFLADSLSIDSKSHPNVLTRFEPFTLLSALAQVTSKIGLTATASTTYS EPFHIARQFASLDHLSNGRAGWNVVTSSIESTALNFSGEKHLEHHLRYQRAEEFVEIV KGLWDSWEEDAFIRNKETGEFFDKEKMHELNHKGEYFSVRGPLNVSRTPQGQPVIIQA GSSGDGKALAAKTAEVIFTAQNHLESAQEFYQSIKEQAAEFGRDPEKIAIMPGIFPII ADTEEAAQAKYKELQDLIIPSVGLQILQNYLGGIDLSAYPLDGPLPKLDAEASNAVKS RFKLVQEMAERDNMTIRELYKYVAGSRGHHIFVGTPEQLADKMQEWVDTKACDGFNIM PPLLPEGIEVFVDQVVPILQERGVFRKEYEGTTLREHFGLEKPVNRYAK*" /label="yxeK CDS" gene complement(3711932..3713257) /gene="yxeK" /locus_tag="BSU_39520" /old_locus_tag="BSU39520" /label="yxeK gene" promotor_-10 complement(3713334..3713353) /Source="Nicolas_upshift_promotors" /id="U3111" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.64035964035964" /psig=1 /xcortree=1742 /SigmaFactorBS="aatagaaaaaattaatcttaactcATTGACAAacgtccaaga caaAGGTACATTTTGATTTATTCatattaaacgactaggaatataggagtttattttt c" /listShort="yxeK, yxeL, yxeM, yxeN, yxeO, yxeP, yxeQ, yxeR, yxxB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3713338) /Source="Nicolas_upshifts" /id="U3111" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.64035964035964" /psig=1 /xcortree=1742 /SigmaFactorBS="aatagaaaaaattaatcttaactcATTGACAAacgtccaaga caaAGGTACATTTTGATTTATTCatattaaacgactaggaatataggagtttattttt c" /listShort="yxeK, yxeL, yxeM, yxeN, yxeO, yxeP, yxeQ, yxeR, yxxB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3713367..3713374) /Source="Nicolas_upshift_promotors" /id="U3111" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.64035964035964" /psig=1 /xcortree=1742 /SigmaFactorBS="aatagaaaaaattaatcttaactcATTGACAAacgtccaaga caaAGGTACATTTTGATTTATTCatattaaacgactaggaatataggagtttattttt c" /listShort="yxeK, yxeL, yxeM, yxeN, yxeO, yxeP, yxeQ, yxeR, yxxB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3713443..3713670) /gene="yxeJ" /locus_tag="BSU_39530" /old_locus_tag="BSU39530" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="NP_391832.2" /db_xref="EnsemblGenomes-Gn:BSU39530" /db_xref="EnsemblGenomes-Tr:CAB15989" /db_xref="SubtiList:BG11886" /db_xref="UniProtKB/Swiss-Prot:P54949" /translation="MSLINSHQSADSGLNIWSQLFFYTIVTASEWIGGLQKRRKGKGN GEILYEIIGRKLSLCFIRLSFLADIEVALVE*" /label="yxeJ CDS" gene complement(3713443..3713670) /gene="yxeJ" /locus_tag="BSU_39530" /old_locus_tag="BSU39530" /label="yxeJ gene" CDS complement(3713657..3714643) /gene="yxeI" /locus_tag="BSU_39540" /old_locus_tag="BSU39540" /EC_number="3.5.1.11" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15937167, 16511127, 18667582, 21978958" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15937167, 16511127, 18667582, 21978958; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="penicillin V amidase" /protein_id="NP_391833.2" /db_xref="EnsemblGenomes-Gn:BSU39540" /db_xref="EnsemblGenomes-Tr:CAB15990" /db_xref="GOA:P54948" /db_xref="InterPro:IPR029055" /db_xref="InterPro:IPR029132" /db_xref="PDB:2OQC" /db_xref="SubtiList:BG11885" /db_xref="UniProtKB/Swiss-Prot:P54948" /translation="MCTSLTLETADRKHVLARTMDFAFQLGTEVILYPRRYSWNSEAD GRAHQTQYAFIGMGRKLGNILFADGINESGLSCAALYFPGYAEYEKTIREDTVHIVPH EFVTWVLSVCQSLEDVKEKIRSLTIVEKKLDLLDTVLPLHWILSDRTGRNLTIEPRAD GLKVYDNQPGVMTNSPDFIWHVTNLQQYTGIRPKQLESKEMGGLALSAFGQGLGTVGL PGDYTPPSRFVRAVYLKEHLEPAADETKGVTAAFQILANMTIPKGAVITEEDEIHYTQ YTSVMCNETGNYYFHHYDNRQIQKVNLFHEDLDCLEPKVFSAKAEESIHELN*" /label="yxeI CDS" gene complement(3713657..3714643) /gene="yxeI" /locus_tag="BSU_39540" /old_locus_tag="BSU39540" /label="yxeI gene" downshifts complement(3713661) /Source="Nicolas_upshifts" /id="D2046" /incds=0 /nref=7 /ntot=52 /MaxReadThrough="2.95669" /MaxDrop="3.32309" /score="23.0334771" /energy="-17.9" /TU="NA" /idTUdmin="U3113" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-35 3713794..3713803 /Source="Nicolas_upshift_promotors" /id="U3112" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=1238 /SigmaFactorBS="agtggtggaaatagtagtttccagtttCGTTGCACATcacgg aagtatatTGCGTATAATGAATTTCGTCttcttccgttatcactgcgccctttggtat c" /listShort="S1520" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3713817..3713836 /Source="Nicolas_upshift_promotors" /id="U3112" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=1238 /SigmaFactorBS="agtggtggaaatagtagtttccagtttCGTTGCACATcacgg aagtatatTGCGTATAATGAATTTCGTCttcttccgttatcactgcgccctttggtat c" /listShort="S1520" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3713827..3714460 /Source="Nicolas_S_feature" /locus_tag="new_4062713_4063346" /HighExp="S6, S7, S8, S5, Paraq, G150, H2O2, G180, LBGexp, Oxctl" /AntisenseName="yxeI" /AntisenseCor="0.24221971906572701" /AntisenseRegPval="-4.2" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig="0.98" /TUlongSig="NA" /TUlongPSig="NA" /label="S1520" upshifts 3713827 /Source="Nicolas_upshifts" /id="U3112" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.98001998001998" /psig="0.98001998001998" /xcortree=1238 /SigmaFactorBS="agtggtggaaatagtagtttccagtttCGTTGCACATcacgg aagtatatTGCGTATAATGAATTTCGTCttcttccgttatcactgcgccctttggtat c" /listShort="S1520" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3714698..3714717) /Source="Nicolas_upshift_promotors" /id="U3113" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.997002997002997" /psig="0.999000999001" /xcortree=629 /SigmaFactorBS="ttttttcgttttatttgatgtaatgtcaatTCTTTGACgaat cgatttgactTTCGTTATGCTGATAAAACCaattcgttcacaatatgtatgatattaa t" /listShort="yxeI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3714709) /Source="Nicolas_upshifts" /id="U3113" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.997002997002997" /psig="0.999000999001" /xcortree=629 /SigmaFactorBS="ttttttcgttttatttgatgtaatgtcaatTCTTTGACgaat cgatttgactTTCGTTATGCTGATAAAACCaattcgttcacaatatgtatgatattaa t" /listShort="yxeI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3714732..3714739) /Source="Nicolas_upshift_promotors" /id="U3113" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.997002997002997" /psig="0.999000999001" /xcortree=629 /SigmaFactorBS="ttttttcgttttatttgatgtaatgtcaatTCTTTGACgaat cgatttgactTTCGTTATGCTGATAAAACCaattcgttcacaatatgtatgatattaa t" /listShort="yxeI" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3714798..3715610) /gene="hadM" /locus_tag="BSU_39550" /old_locus_tag="BSU39550" /EC_number="3.1.3.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 21575135, 23582330, 25527541, 25848029, 27435445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sugar-phosphate hydrolase (promiscuous)" /protein_id="NP_391834.1" /db_xref="EnsemblGenomes-Gn:BSU39550" /db_xref="EnsemblGenomes-Tr:CAB15991" /db_xref="GOA:P54947" /db_xref="InterPro:IPR000150" /db_xref="InterPro:IPR006379" /db_xref="InterPro:IPR023214" /db_xref="InterPro:IPR036412" /db_xref="SubtiList:BG11884" /db_xref="UniProtKB/Swiss-Prot:P54947" /translation="MYKLIAIDMDGTLLNDHHEVTEEVRDALHAAKAEGVKIVLCTGR PIGGVQRYLDELNLIEEGDYVIAYNGALVQNTHTNEVVSELSLGYDDLTSLYDLSLEL KTPMHFFDSSNLYTPNRDISEFTVYESYVTQVPLHFRKIDEVPKDILIPKVMFIDKPE NLSRVITSIPKDVREKYTMVRSAPFFYEILHSEASKGNAVRQLAQLLGIEQAEVMCIG DNGNDLTMIEWAGCGVAMANAIPEVLEAANFQTRSNNEHGVAHAIHELVLAK*" /label="hadM CDS" gene complement(3714798..3715610) /gene="hadM" /locus_tag="BSU_39550" /old_locus_tag="BSU39550" /label="hadM gene" promotor_-10 complement(3715640..3715659) /Source="Nicolas_upshift_promotors" /id="U3114" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.853146853146853" /psig="0.998001998001998" /xcortree=2354 /SigmaFactorBS="aagggcggcgtctaaacagaatccggagaaaaccatctcttc CGGTTGAAtatcaaaaagaaaaAACGATATGATGGGACTATAgcctgaaaacgacatg a" /listShort="yxeH" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(3715650..3716207) /gene="yxeG" /locus_tag="BSU_39560" /old_locus_tag="BSU39560" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein of unknown function" /protein_id="NP_391835.1" /db_xref="EnsemblGenomes-Gn:BSU39560" /db_xref="EnsemblGenomes-Tr:CAB15992" /db_xref="GOA:P54946" /db_xref="SubtiList:BG11883" /db_xref="UniProtKB/Swiss-Prot:P54946" /translation="MRNQKAERLVAAGLVLHIIQWIFILWAFLKVKHLFSDYTIYNPN VISGSMQSLSFIQMMRAMMYSGAIVNYVLFFALVLLIYGIVLHAILIVLEMAAYVMIR RNPSSSWGFFFIAAGVKLAILNITGIPFLAAGFLLMKQKKAENGVKAERKRKPRLRIR RQGRRLNRIRRKPSLPVEYQKEKTI*" /label="yxeG CDS" gene complement(3715650..3716207) /gene="yxeG" /locus_tag="BSU_39560" /old_locus_tag="BSU39560" /label="yxeG gene" upshifts complement(3715663) /Source="Nicolas_upshifts" /id="U3114" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.853146853146853" /psig="0.998001998001998" /xcortree=2354 /SigmaFactorBS="aagggcggcgtctaaacagaatccggagaaaaccatctcttc CGGTTGAAtatcaaaaagaaaaAACGATATGATGGGACTATAgcctgaaaacgacatg a" /listShort="yxeH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3715674..3715681) /Source="Nicolas_upshift_promotors" /id="U3114" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.853146853146853" /psig="0.998001998001998" /xcortree=2354 /SigmaFactorBS="aagggcggcgtctaaacagaatccggagaaaaccatctcttc CGGTTGAAtatcaaaaagaaaaAACGATATGATGGGACTATAgcctgaaaacgacatg a" /listShort="yxeH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3716188..3716622) /gene="yxeF" /locus_tag="BSU_39570" /old_locus_tag="BSU39570" /function="18: Unknown function" /experiment="publication(s) with functional evidences, PMID:11160890, 22693626" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11160890, 22693626; Product type s: structure" /codon_start=1 /transl_table=11 /product="lipocalin-like lipoprotein" /protein_id="NP_391836.1" /db_xref="EnsemblGenomes-Gn:BSU39570" /db_xref="EnsemblGenomes-Tr:CAB15993" /db_xref="InterPro:IPR012674" /db_xref="InterPro:IPR021664" /db_xref="PDB:2JOZ" /db_xref="SubtiList:BG11882" /db_xref="UniProtKB/Swiss-Prot:P54945" /translation="MVIPLRNKYGILFLIAVCIMVSGCQQQKEETPFYYGTWDEGRAP GPTDGVKSATVTFTEDEVVETEVMEGRGEVQLPFMAYKVISQSTDGSIEIQYLGPYYP LKSTLKRGENGTLIWEQNGQRKTMTRIESKTGREEKDEKSKS*" /label="yxeF CDS" gene complement(3716188..3716622) /gene="yxeF" /locus_tag="BSU_39570" /old_locus_tag="BSU39570" /label="yxeF gene" promotor_-35 3716647..3716656 /Source="Nicolas_upshift_promotors" /id="U3115" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1295 /SigmaFactorBS="ctcaaggggatcaccattctttcctccttttttgggcgaatG CCGTGCCACtgtgccaatgacTACATAAGTTATAAGGAATTcacccacaaggagactg a" /listShort="yxeE" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3716666 /Source="Nicolas_upshifts" /id="U3115" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1295 /SigmaFactorBS="ctcaaggggatcaccattctttcctccttttttgggcgaatG CCGTGCCACtgtgccaatgacTACATAAGTTATAAGGAATTcacccacaaggagactg a" /listShort="yxeE" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3716669..3716688 /Source="Nicolas_upshift_promotors" /id="U3115" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1295 /SigmaFactorBS="ctcaaggggatcaccattctttcctccttttttgggcgaatG CCGTGCCACtgtgccaatgacTACATAAGTTATAAGGAATTcacccacaaggagactg a" /listShort="yxeE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3716682) /Source="Nicolas_upshifts" /id="U3116" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.995004995004995" /psig="0.004995004995005" /xcortree=689 /SigmaFactorBS="agctgagggctgtaatattgataagggTTCATgtgatcagTC TCCTTGTGGGTGAattccttataacttatgtagtcattggcacagtggcacggcattc g" /listShort="yxeF, yxeG, yxeH" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3716683..3717094) /Source="Nicolas_S_feature" /locus_tag="new_4065569_4065980_c" /HighExp="Salt, H2O2, Paraq, dia15, Oxctl, Diami, Cold, G150, Lbtran, LBGexp" /AntisenseName="yxeE" /AntisenseCor="-0.602938477548701" /AntisenseRegPval="-27.3" /CDS_PredictionProba="NA" /TUshortSig="Sig-, SigA" /TUshortPSig="0.391, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1521" promotor_-10 complement(3716688..3716702) /Source="Nicolas_upshift_promotors" /id="U3116" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.995004995004995" /psig="0.004995004995005" /xcortree=689 /SigmaFactorBS="agctgagggctgtaatattgataagggTTCATgtgatcagTC TCCTTGTGGGTGAattccttataacttatgtagtcattggcacagtggcacggcattc g" /listShort="yxeF, yxeG, yxeH" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3716711..3716715) /Source="Nicolas_upshift_promotors" /id="U3116" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.995004995004995" /psig="0.004995004995005" /xcortree=689 /SigmaFactorBS="agctgagggctgtaatattgataagggTTCATgtgatcagTC TCCTTGTGGGTGAattccttataacttatgtagtcattggcacagtggcacggcattc g" /listShort="yxeF, yxeG, yxeH" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3716711..3717076 /gene="cotNE" /locus_tag="BSU_39580" /old_locus_tag="BSU39580" /function="16.8: Protect" /function="16.13: Shape" /function="16.5: Explore" /experiment="publication(s) with functional evidences, PMID:10714992, 17905812, 19933362" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10714992, 17905812, 19933362; Product type s: structure" /codon_start=1 /transl_table=11 /product="inner spore coat protein" /protein_id="NP_391837.1" /db_xref="EnsemblGenomes-Gn:BSU39580" /db_xref="EnsemblGenomes-Tr:CAB15994" /db_xref="SubtiList:BG11881" /db_xref="UniProtKB/Swiss-Prot:P54944" /translation="MNPYQYYSPQLPQQEPYYSHYEYNPYPQQDVYDPYQMDRQPALE RRIAALERQNEQQSRELTRLTNEDRRQNREIARIAEQVNQLSQAVERHTRRLNRLNQR LRTVENRLNIPFTAGEGGF*" /label="cotNE CDS" gene 3716711..3717076 /gene="cotNE" /locus_tag="BSU_39580" /old_locus_tag="BSU39580" /label="cotNE gene" downshifts 3717090 /Source="Nicolas_upshifts" /id="D2047" /incds=0 /nref=31 /ntot=47 /MaxReadThrough="1.46494" /MaxDrop="8.36553" /score="27.2157513" /energy="-12.2" /TU="U3115" /idTUdmin="U3115" /TUdmin="-38" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3717094..3717098) /Source="Nicolas_upshift_promotors" /id="U3117" /multdbtbs="-" /comp="M9" /sig="Sig-" /pcomp="0.390609390609391" /psig="0.390609390609391" /xcortree=290 /SigmaFactorBS="cgttttaacatataagaaatgcggaaaacgaaaccCtgagat gggagaatcgtattCCGCTttttttctttgtttcgctcagaaaccgccttcccctgca g" /listShort="S1521" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3717094) /Source="Nicolas_upshifts" /id="U3117" /multdbtbs="-" /comp="M9" /sig="Sig-" /pcomp="0.390609390609391" /psig="0.390609390609391" /xcortree=290 /SigmaFactorBS="cgttttaacatataagaaatgcggaaaacgaaaccCtgagat gggagaatcgtattCCGCTttttttctttgtttcgctcagaaaccgccttcccctgca g" /listShort="S1521" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3717096..3717182) /Source="Nicolas_S_feature" /locus_tag="new_4065982_4066068_c" /HighExp="Salt, S8, H2O2, dia15, S7, Paraq, Diami, aero, Oxctl, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1522" promotor_-10 complement(3717175..3717194) /Source="Nicolas_upshift_promotors" /id="U3118" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig=1 /xcortree=2444 /SigmaFactorBS="ctacaattattttcctcagcccctctaTCTTTGAAtgaaaac ggtaaaGATTGTATACTGGGTACAAAccctttttatgtaaatgttccgttttaacata t" /listShort="S1522, S1521, yxeF, yxeG, yxeH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3717182) /Source="Nicolas_upshifts" /id="U3118" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig=1 /xcortree=2444 /SigmaFactorBS="ctacaattattttcctcagcccctctaTCTTTGAAtgaaaac ggtaaaGATTGTATACTGGGTACAAAccctttttatgtaaatgttccgttttaacata t" /listShort="S1522, S1521, yxeF, yxeG, yxeH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3717208..3717215) /Source="Nicolas_upshift_promotors" /id="U3118" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.74925074925075" /psig=1 /xcortree=2444 /SigmaFactorBS="ctacaattattttcctcagcccctctaTCTTTGAAtgaaaac ggtaaaGATTGTATACTGGGTACAAAccctttttatgtaaatgttccgttttaacata t" /listShort="S1522, S1521, yxeF, yxeG, yxeH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3717255..3717261 /Source="Nicolas_upshift_promotors" /id="U3119" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.97002997002997" /psig="0.97002997002997" /xcortree=861 /SigmaFactorBS="ggctgaggaaaataattgtagttcctctttgacGGAATTTct tttcattcaagTTGCATGATAATaccgactcacgtcaatcgatacatggagggatcat t" /listShort="yxeD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3717275..3717286 /Source="Nicolas_upshift_promotors" /id="U3119" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.97002997002997" /psig="0.97002997002997" /xcortree=861 /SigmaFactorBS="ggctgaggaaaataattgtagttcctctttgacGGAATTTct tttcattcaagTTGCATGATAATaccgactcacgtcaatcgatacatggagggatcat t" /listShort="yxeD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3717282 /Source="Nicolas_upshifts" /id="U3119" /multdbtbs="SigG" /comp="M8" /sig="SigGF" /pcomp="0.97002997002997" /psig="0.97002997002997" /xcortree=861 /SigmaFactorBS="ggctgaggaaaataattgtagttcctctttgacGGAATTTct tttcattcaagTTGCATGATAATaccgactcacgtcaatcgatacatggagggatcat t" /listShort="yxeD" /GFF_Attribute="listLong" /label="upshifts" CDS 3717324..3717677 /gene="yxeD" /locus_tag="BSU_39590" /old_locus_tag="BSU39590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 26506528" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391838.2" /db_xref="EnsemblGenomes-Gn:BSU39590" /db_xref="EnsemblGenomes-Tr:CAB15995" /db_xref="SubtiList:BG11880" /db_xref="UniProtKB/Swiss-Prot:P54943" /translation="MHNTQHGLQQLNQCRQTAQQLIQQTQQSSQQYRQMLHQEQQNIQ MLQQILNHEQQAAHTIQQALHGHDMAIQKCQQVVNMCNQMQQELTGQSSVMNTNVSTL PFGQNTTFQQQSYQQ*" /label="yxeD CDS" gene 3717324..3717677 /gene="yxeD" /locus_tag="BSU_39590" /old_locus_tag="BSU39590" /label="yxeD gene" downshifts 3717672 /Source="Nicolas_upshifts" /id="D2048" /incds=0 /nref=24 /ntot=55 /MaxReadThrough="0.20641" /MaxDrop="6.88486" /score="27.2157513" /energy="-12.2" /TU="NA" /idTUdmin="U3119" /TUdmin="-6" /isTUend="TRUE" /label="downshifts" CDS complement(3717721..3718119) /gene="yxeC" /locus_tag="BSU_39600" /old_locus_tag="BSU39600" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein of unknown function" /protein_id="NP_391839.2" /db_xref="EnsemblGenomes-Gn:BSU39600" /db_xref="EnsemblGenomes-Tr:CAB15996" /db_xref="GOA:P54942" /db_xref="SubtiList:BG11879" /db_xref="UniProtKB/Swiss-Prot:P54942" /translation="MGITKRGAAWEWLHSWWMLFIFMPFAITSFFAFLFIGIKVRNRK WIMYGIIYFFIFAFGFVLPDLPGVFIVVPLWAVTIIHGFKVRPLYLIQLDVYKDHVEA RAFAEARSEAESRFHAPKQSIQDIHIRKEQ*" /label="yxeC CDS" gene complement(3717721..3718119) /gene="yxeC" /locus_tag="BSU_39600" /old_locus_tag="BSU39600" /label="yxeC gene" downshifts complement(3717729) /Source="Nicolas_upshifts" /id="D2049" /incds=0 /nref=145 /ntot=243 /MaxReadThrough="1.70512" /MaxDrop="5.26494" /score="9.81431167" /energy="-12.2" /TU="NA" /idTUdmin="U3120" /TUdmin=3 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3718134..3718153) /Source="Nicolas_upshift_promotors" /id="U3120" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.602397602397602" /psig="0.999000999001" /xcortree=2316 /SigmaFactorBS="tatcactatttttaagggagaaagtttttcccgtttatgGGT GacgcggtgtgcctaATCGATTATTATAGGTAAATaggaggagaaaaatatgggaatt a" /listShort="yxeC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3718150) /Source="Nicolas_upshifts" /id="U3120" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.602397602397602" /psig="0.999000999001" /xcortree=2316 /SigmaFactorBS="tatcactatttttaagggagaaagtttttcccgtttatgGGT GacgcggtgtgcctaATCGATTATTATAGGTAAATaggaggagaaaaatatgggaatt a" /listShort="yxeC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3718168..3718171) /Source="Nicolas_upshift_promotors" /id="U3120" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.602397602397602" /psig="0.999000999001" /xcortree=2316 /SigmaFactorBS="tatcactatttttaagggagaaagtttttcccgtttatgGGT GacgcggtgtgcctaATCGATTATTATAGGTAAATaggaggagaaaaatatgggaatt a" /listShort="yxeC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3718207..3718214 /Source="Nicolas_upshift_promotors" /id="U3121" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.585414585414585" /psig=1 /xcortree=2105 /SigmaFactorBS="cgggaaaaactttctcccttaaaaatagtGATAGACGgagaa caggtttctTGCTATATTATTAATTGATAatgataatcattactaatctattgagata c" /listShort="yxeB, S1523" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3718223..3718241) /Source="Nicolas_upshift_promotors" /id="U3122" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.96903096903097" /psig="0.96903096903097" /xcortree=775 /SigmaFactorBS="atcaagaaccctcccactatgtatctcaatagattaGTAATG attatcattatcaatTAATAATATAGCAAGAAACctgttctccgtctatcactatttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 3718229..3718248 /Source="Nicolas_upshift_promotors" /id="U3121" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.585414585414585" /psig=1 /xcortree=2105 /SigmaFactorBS="cgggaaaaactttctcccttaaaaatagtGATAGACGgagaa caggtttctTGCTATATTATTAATTGATAatgataatcattactaatctattgagata c" /listShort="yxeB, S1523" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3718238 /Source="Nicolas_upshifts" /id="U3121" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.585414585414585" /psig=1 /xcortree=2105 /SigmaFactorBS="cgggaaaaactttctcccttaaaaatagtGATAGACGgagaa caggtttctTGCTATATTATTAATTGATAatgataatcattactaatctattgagata c" /listShort="yxeB, S1523" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(3718238) /Source="Nicolas_upshifts" /id="U3122" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.96903096903097" /psig="0.96903096903097" /xcortree=775 /SigmaFactorBS="atcaagaaccctcccactatgtatctcaatagattaGTAATG attatcattatcaatTAATAATATAGCAAGAAACctgttctccgtctatcactatttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3718257..3718262) /Source="Nicolas_upshift_promotors" /id="U3122" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.96903096903097" /psig="0.96903096903097" /xcortree=775 /SigmaFactorBS="atcaagaaccctcccactatgtatctcaatagattaGTAATG attatcattatcaatTAATAATATAGCAAGAAACctgttctccgtctatcactatttt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3718297..3719262 /gene="frxB" /locus_tag="BSU_39610" /old_locus_tag="BSU39610" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 1c: Function from experimental evidences in the studied genus; PubMedId: 12354229, 16672620, 8388528, 19254027, 23924612, 25007174; Product type t : transporter" /codon_start=1 /transl_table=11 /product="desferrioxamine-and ferrichrome-binding transporter lipoprotein (shuttle system)" /protein_id="NP_391840.2" /db_xref="EnsemblGenomes-Gn:BSU39610" /db_xref="EnsemblGenomes-Tr:CAB15997" /db_xref="GOA:P54941" /db_xref="InterPro:IPR002491" /db_xref="SubtiList:BG11878" /db_xref="UniProtKB/Swiss-Prot:P54941" /translation="MKKNILLVGMLVLLLMFVSACSGTASKGSSSDSASEKTEMRTYK SPKGNVNIPAHPKRIVTDFYAGELLSVGANVVGSGSWSFDNPFLKSKLKNVKDVGDPI SVEKVMELQPDLIVVMNEENVDKLKKIAPTVVIPYNTAKNVEDTVSMFGDIAGAKDQA KSFMADFNKKAEAAKKKIAGVIDKDATFGIYENTDKGEFWVFNDNGGRGGQAVYNALG LKAPEKIEQDVIKKGEMKQLSQEVIPEYAADYMFITDYNPKGESKTLDKLENSSIWKN LDAVKHNRVFINDFDSFYPYDPISVSKQVDIITDMLIKRAEENKK*" /label="frxB CDS" gene 3718297..3719262 /gene="frxB" /locus_tag="BSU_39610" /old_locus_tag="BSU39610" /label="frxB gene" upshifts 3718690 /Source="Nicolas_upshifts" /id="U3123" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.726273726273726" /psig="0.726273726273726" /xcortree=773 /SigmaFactorBS="cctgacttaattgttgtcatgaatgaagagaatgttgataaa ttaaagaaaatcgctccgactgttgTCATACCTTATAACACAGCgaaaaacgtagaag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" misc_feature 3718697..3718715 /Source="Nicolas_upshift_promotors" /id="U3123" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.726273726273726" /psig="0.726273726273726" /xcortree=773 /SigmaFactorBS="cctgacttaattgttgtcatgaatgaagagaatgttgataaa ttaaagaaaatcgctccgactgttgTCATACCTTATAACACAGCgaaaaacgtagaag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" downshifts 3719169 /Source="Nicolas_upshifts" /id="D2050" /incds=1 /nref=55 /ntot=191 /MaxReadThrough="6.103" /MaxDrop="4.3334" /score="22.3558496" /energy="-13.4" /TU="U3121" /idTUdmin="U3123" /TUdmin=193 /isTUend="FALSE" /label="downshifts" downshifts 3719240 /Source="Nicolas_upshifts" /id="D2051" /incds=0 /nref=1 /ntot=62 /MaxReadThrough="4.41732" /MaxDrop="3.7101" /score="22.3558496" /energy="-13.4" /TU="U3121" /idTUdmin="U3123" /TUdmin=264 /isTUend="FALSE" /label="downshifts" S_feature 3719285..3720081 /Source="Nicolas_S_feature" /locus_tag="new_4068171_4068967" /HighExp="H2O2, Paraq, Lbexp, dia0, LBGexp, G150, B36, dia15, B60, GM 25" /AntisenseName="yxeA" /AntisenseCor="0.20524492145617201" /AntisenseRegPval="-3.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1523" CDS complement(3719303..3719650) /gene="yxeA" /locus_tag="BSU_39620" /old_locus_tag="BSU39620" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391841.1" /db_xref="EnsemblGenomes-Gn:BSU39620" /db_xref="EnsemblGenomes-Tr:CAB15998" /db_xref="InterPro:IPR006542" /db_xref="InterPro:IPR036166" /db_xref="PDB:3NPP" /db_xref="SubtiList:BG11877" /db_xref="UniProtKB/Swiss-Prot:P54940" /translation="MKKAMAILAVLAAAAVICGLLFFHNDVTDRFNPFIHQQDVYVQI DRDGRHLSPGGTEYTLDGYNASGKKEEVTFFAGKELRKNAYLKVKAKGKYVETWEEVK FEDMPDSVQSKLK*" /label="yxeA CDS" gene complement(3719303..3719650) /gene="yxeA" /locus_tag="BSU_39620" /old_locus_tag="BSU39620" /label="yxeA gene" downshifts complement(3719316) /Source="Nicolas_upshifts" /id="D2052" /incds=0 /nref=2 /ntot=78 /MaxReadThrough="1.28842" /MaxDrop="2.99568" /score="38.5550476" /energy="-11.6" /TU="NA" /idTUdmin="U3120" /TUdmin="-1584" /isTUend="FALSE" /label="downshifts" CDS complement(3719664..3721532) /gene="tpeM" /locus_tag="BSU_39630" /old_locus_tag="BSU39630" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15289557, 15849754, 15870467, 16850406, 21078927, 28472044" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15289557, 15849754, 15870467, 16850406, 21078927, 28472044; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (permease); efflux of cationic peptides" /protein_id="NP_391842.2" /db_xref="EnsemblGenomes-Gn:BSU39630" /db_xref="EnsemblGenomes-Tr:CAB15999" /db_xref="GOA:P42424" /db_xref="InterPro:IPR003838" /db_xref="InterPro:IPR027022" /db_xref="SubtiList:BG11129" /db_xref="UniProtKB/Swiss-Prot:P42424" /translation="MTFLQFAYKNVTRNKRAYLAFFLSSAFSVLIFFTFAMFLFHPAL KEGYLNNIAKKGLTAAEWMIFVFSFLFVLYSVNAFLKSRNKEFGILLMQGITPGQLRK LITAENMIIGVMSIAAGIIGGFIFSKTFFTVGAYILEMDALPLYMPWKALGITACGFL LLFFFLSQFTILFVRSNTVIKLIKGTGKVKPEPKPSVLLSLFGIACLCGGYGMVLKGN VHGAEPFIILLLTVIGTYFFFSQSSIWILRALKKWKTFYLRGKNIIWVSDLVYRLKDN ARLFFIVSIISAVAFTATGVLAMYKSTVGAEESAYEMEYLSYSNNPKEQTHLKDIDHE LKTHGFTYTKDKIDVSYVRYQEGETVPPVYMISESDAAKYFHVKVNGLKEDEAVYFPG TYDRNFKNEAPDQLKLLNQKGELSDQKLSVKEVKKPLISLNAIIAVNDQTFDQLKSLG DKASLYGYSYDHWKDSLEISQSLQNEIYGNYIDVHSDFASKAGTYYDTVQLPSLSLFI GLFIAIVFFVAAASFLYFRLFTDLDEDRERYRSLAKIGLSEREMAQSVTIQLAILFFF PFVIAVMHTLFALRTLAVEGYSDVAGPLSLTIGGFFIFQLLFFLAVRSSYLKKMNK*" /label="tpeM CDS" gene complement(3719664..3721532) /gene="tpeM" /locus_tag="BSU_39630" /old_locus_tag="BSU39630" /label="tpeM gene" CDS complement(3721507..3722280) /gene="tpeL" /locus_tag="BSU_39640" /old_locus_tag="BSU39640" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15289557, 15870467, 17600057, 21078927, 28472044" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15289557, 15870467, 17600057, 21078927, 28472044; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC transporter (ATP-binding protein); efflux ofcationic peptides" /protein_id="NP_391843.2" /db_xref="EnsemblGenomes-Gn:BSU39640" /db_xref="EnsemblGenomes-Tr:CAB16000" /db_xref="GOA:P42423" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11128" /db_xref="UniProtKB/Swiss-Prot:P42423" /translation="MANMLEVKHINKTYKGQVSYQALKQISFSIEEGEFTAVMGPSGS GKTTLLNIISTIDRPDSGDILINGENPHRLKRTKLAHFRRKQLGFVFQDFNLLDTLTI GENIMLPLTLEKEAPSVMEEKLHGIAAKLGIENLLNKRTFEVSGGQRQRAAIARAVIH KPSLILADEPTGNLDSKATKDVMETLQSLNRDDHVTALMVTHDPVSASYCRRVIFIKD GELFNEIYRGENRQVFYEQILDVLSMLGGNANDLSSVRL*" /label="tpeL CDS" gene complement(3721507..3722280) /gene="tpeL" /locus_tag="BSU_39640" /old_locus_tag="BSU39640" /label="tpeL gene" CDS complement(3722424..3723401) /gene="tpeK" /locus_tag="BSU_39650" /old_locus_tag="BSU39650" /EC_number="2.7.13.3" /function="16.12: Sense" /experiment="publication(s) with functional evidences, PMID:11717295, 15289557, 15870467, 21283517, 25875741" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15289557, 15870467, 21283517, 25875741; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YxdJ]" /protein_id="NP_391844.1" /db_xref="EnsemblGenomes-Gn:BSU39650" /db_xref="EnsemblGenomes-Tr:CAB16001" /db_xref="GOA:P42422" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR036890" /db_xref="SubtiList:BG11127" /db_xref="UniProtKB/Swiss-Prot:P42422" /translation="MKLFLRSHAVLILLFLLQGLFVFFYYWFAGLHSFSHLFYILGVQ LLILAGYLAYRWYKDRGVYHWLSSGQEGTDIPYLGSSVFCSELYEKQMELIRLQHQKL HETEAKLDARVTYMNQWVHQVKTPLSVINLIIQEEDEPVFEQIKKEVRQIEFGLETLL YSSRLDLFERDFKIEAVSLSELLQSVIQSYKRFFIQYRVYPKMNVCDDHQIYTDAKWL KFAIGQVVTNAVKYSAGKSDRLELNVFCDEDRTVLEVKDYGVGIPSQDIKRVFDPYYT GENGRRFQESTGIGLHLVKEITDKLNHTVDISSSPGEGTSVRFSFLTKM*" /label="tpeK CDS" gene complement(3722424..3723401) /gene="tpeK" /locus_tag="BSU_39650" /old_locus_tag="BSU39650" /label="tpeK gene" CDS complement(3723398..3724087) /gene="tpeJ" /locus_tag="BSU_39660" /old_locus_tag="BSU39660" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:11717295, 15289557, 15870467, 21283517, 25875741" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11717295, 15289557, 15870467, 21283517, 25875741; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [TpeK(YxdK)]" /protein_id="NP_391845.1" /db_xref="EnsemblGenomes-Gn:BSU39660" /db_xref="EnsemblGenomes-Tr:CAB16002" /db_xref="GOA:P42421" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="SubtiList:BG11126" /db_xref="UniProtKB/Swiss-Prot:P42421" /translation="MNKIMIVEDSEDIRGLLQNYLEKYGYQTVVAADFTAVLDVFLRE KPDVVLLDINLPAYDGYYWCRQIRQHSTSPIIFISARSGEMDQVMAIENGGDDYIEKP FSYDIVLAKIKSQIRRAYGEYAAKQGEKVVEYAGVQLFVERFELRFQDEKSELSKKES KLLEVLLERGEKVTSRDRLMEKTWDTDIFIDDNTLNVYITRLRKKLRELNAPVSIEAV RGEGYQLRAQS*" /label="tpeJ CDS" gene complement(3723398..3724087) /gene="tpeJ" /locus_tag="BSU_39660" /old_locus_tag="BSU39660" /label="tpeJ gene" promotor_-10 complement(3724114..3724133) /Source="Nicolas_upshift_promotors" /id="U3124" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.440559440559441" /psig="0.963036963036963" /xcortree=1786 /SigmaFactorBS="agaccagaaaccgccgagatggcggtttttttgtgcggTGTT GCGtccatacgcccaaaACGATTATGATGATGGCAGCagtgtaagaaacgggagtggt t" /listShort="yxdJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3724132) /Source="Nicolas_upshifts" /id="U3124" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.440559440559441" /psig="0.963036963036963" /xcortree=1786 /SigmaFactorBS="agaccagaaaccgccgagatggcggtttttttgtgcggTGTT GCGtccatacgcccaaaACGATTATGATGATGGCAGCagtgtaagaaacgggagtggt t" /listShort="yxdJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3724148..3724154) /Source="Nicolas_upshift_promotors" /id="U3124" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.440559440559441" /psig="0.963036963036963" /xcortree=1786 /SigmaFactorBS="agaccagaaaccgccgagatggcggtttttttgtgcggTGTT GCGtccatacgcccaaaACGATTATGATGATGGCAGCagtgtaagaaacgggagtggt t" /listShort="yxdJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3724195..3725067) /gene="iolJ" /locus_tag="BSU_39670" /old_locus_tag="BSU39670" /EC_number="4.1.2.29" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9226270, 10658656, 11325924, 18310071" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9226270, 10658656, 11325924, 18310071; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="2-deoxy-5-keto-D-gluconic acid 6-phosphate aldolase" /protein_id="NP_391846.1" /db_xref="EnsemblGenomes-Gn:BSU39670" /db_xref="EnsemblGenomes-Tr:CAB16003" /db_xref="GOA:P42420" /db_xref="InterPro:IPR000771" /db_xref="InterPro:IPR011289" /db_xref="InterPro:IPR013785" /db_xref="SubtiList:BG11125" /db_xref="UniProtKB/Swiss-Prot:P42420" /translation="MAFVSMKELLEDAKREQYAIGQFNINGLQWTKAILQAAQKEQSP VIAAASDRLVDYLGGFKTIAAMVGALIEDMAITVPVVLHLDHGSSAERCRQAIDAGFS SVMIDGSHQPIDENIAMTKEVTDYAAKHGVSVEAEVGTVGGMEDGLVGGVRYADITEC ERIVKETNIDALAAALGSVHGKYQGEPNLGFKEMEAISRMTDIPLVLHGASGIPQDQI KKAITLGHAKININTECMVAWTDETRRMFQENSDLYEPRGYLTPGIEAVEETVRSKMR EFGSAGKAAKQQVG*" /label="iolJ CDS" gene complement(3724195..3725067) /gene="iolJ" /locus_tag="BSU_39670" /old_locus_tag="BSU39670" /label="iolJ gene" downshifts complement(3724199) /Source="Nicolas_upshifts" /id="D2053" /incds=0 /nref=89 /ntot=172 /MaxReadThrough="3.05314" /MaxDrop="6.87265" /score="26.7325466" /energy="-8.2" /TU="NA" /idTUdmin="U3126" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3725088..3725924) /gene="iolI" /locus_tag="BSU_39680" /old_locus_tag="BSU39680" /EC_number="5.3.99.11" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9887260, 11566986, 12112707, 17619021, 16461681, 18310071, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9887260, 11566986, 12112707, 17619021, 16461681, 18310071, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="inosose isomerase" /protein_id="NP_391847.1" /db_xref="EnsemblGenomes-Gn:BSU39680" /db_xref="EnsemblGenomes-Tr:CAB16004" /db_xref="GOA:P42419" /db_xref="InterPro:IPR013022" /db_xref="InterPro:IPR036237" /db_xref="PDB:1I60" /db_xref="PDB:1I6N" /db_xref="SubtiList:BG11124" /db_xref="UniProtKB/Swiss-Prot:P42419" /translation="MKLCFNEATTLENSNLKLDLELCEKHGYDYIEIRTMDKLPEYLK DHSLDDLAEYFQTHHIKPLALNALVFFNNRDEKGHNEIITEFKGMMETCKTLGVKYVV AVPLVTEQKIVKEEIKKSSVDVLTELSDIAEPYGVKIALEFVGHPQCTVNTFEQAYEI VNTVNRDNVGLVLDSFHFHAMGSNIESLKQADGKKIFIYHIDDTEDFPIGFLTDEDRV WPGQGAIDLDAHLSALKEIGFSDVVSVELFRPEYYKLTAEEAIQTAKKTTVDVVSKYF SM*" /label="iolI CDS" gene complement(3725088..3725924) /gene="iolI" /locus_tag="BSU_39680" /old_locus_tag="BSU39680" /label="iolI gene" S_feature complement(3725925..3726009) /Source="Nicolas_S_feature" /locus_tag="new_4074811_4074895_c" /HighExp="M40t90, M0t90, BI, Sw, BC, T5.0H, T0.30H, T4.0H, T3.30H, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.101524" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1524" CDS complement(3726010..3726879) /gene="iolH" /locus_tag="BSU_39690" /old_locus_tag="BSU39690" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9887260, 11566986, 12112707, 23874669; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative sugar-phosphate epimerase/isomerase" /protein_id="NP_391848.1" /db_xref="EnsemblGenomes-Gn:BSU39690" /db_xref="EnsemblGenomes-Tr:CAB16005" /db_xref="InterPro:IPR013022" /db_xref="InterPro:IPR036237" /db_xref="SubtiList:BG11123" /db_xref="UniProtKB/Swiss-Prot:P42418" /translation="MKLALDPSMYRDDLTLEEMVYKTAELGYEYIELSPREDFCPFYK YPKVDSAKIKQLKRLLRDTGVKLSSLLPLYHWAGPDEDRRQAAVRNWKRAIEIAVELE VDLMNSEFSGSKYDPLTSEEKFIKSMDELLPVFEKEGIKLNLQAHPYDFIETHKGAMD MIRALDKDWINLVYSTAHTFFYDDGKGDIETMFDEAGDRLTHVLFADTYNHKAAHGLR YIVNPPDAKVTVHQHLDIGQGEVDFDTIFRKLREMKFDGIATNAVFAWVDERADESSR FMLKKMKEELGLA*" /label="iolH CDS" gene complement(3726010..3726879) /gene="iolH" /locus_tag="BSU_39690" /old_locus_tag="BSU39690" /label="iolH gene" CDS complement(3726899..3727933) /gene="iolG" /locus_tag="BSU_39700" /old_locus_tag="BSU39700" /EC_number="1.1.1.18" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:112095, 11274120, 15678175, 9226270, 16461681, 18310071, 22720735, 25482235, 28431560" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 112095, 11274120, 15678175, 9226270, 16461681, 18310071, 22720735, 25482235, 28431560; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="myo-inositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase" /protein_id="NP_391849.2" /db_xref="EnsemblGenomes-Gn:BSU39700" /db_xref="EnsemblGenomes-Tr:CAB16006" /db_xref="GOA:P26935" /db_xref="InterPro:IPR000683" /db_xref="InterPro:IPR004104" /db_xref="InterPro:IPR023794" /db_xref="InterPro:IPR036291" /db_xref="PDB:3MZ0" /db_xref="PDB:3NT2" /db_xref="PDB:3NT4" /db_xref="PDB:3NT5" /db_xref="PDB:3NTO" /db_xref="PDB:3NTQ" /db_xref="PDB:3NTR" /db_xref="PDB:4L8V" /db_xref="PDB:4L9R" /db_xref="SubtiList:BG10669" /db_xref="UniProtKB/Swiss-Prot:P26935" /translation="MSLRIGVIGTGAIGKEHINRITNKLSGAEIVAVTDVNQEAAQKV VEQYQLNATVYPNDDSLLADENVDAVLVTSWGPAHESSVLKAIKAQKYVFCEKPLATT AEGCMRIVEEEIKVGKRLVQVGFMRRYDSGYVQLKEALDNHVIGEPLMIHCAHRNPTV GDNYTTDMAVVDTLVHEIDVLHWLVNDDYESVQVIYPKKSKNALPHLKDPQIVVIETK GGIVINAEIYVNCKYGYDIQCEIVGEDGIIKLPEPSSISLRKEGRFSTDILMDWQRRF VAAYDVEIQDFIDSIQKKGEVSGPTAWDGYIAAVTTDACVKAQESGQKEKVELKEKPE FYQSFTTVQN*" /label="iolG CDS" gene complement(3726899..3727933) /gene="iolG" /locus_tag="BSU_39700" /old_locus_tag="BSU39700" /label="iolG gene" CDS complement(3727956..3729272) /gene="iolF" /locus_tag="BSU_39710" /old_locus_tag="BSU39710" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:11807058, 15849754, 16850406, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11807058, 15849754, 16850406, 22720735; Product type t: transporter" /codon_start=1 /transl_table=11 /product="inositol transport protein" /protein_id="NP_391850.2" /db_xref="EnsemblGenomes-Gn:BSU39710" /db_xref="EnsemblGenomes-Tr:CAB16007" /db_xref="GOA:P42417" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11122" /db_xref="UniProtKB/Swiss-Prot:P42417" /translation="MGNTNGDSAFNKRTIAAALANYIDAGSIVAGSAGLSLWVSYLKL SDTQIGLLGALSANAISAAVGALLGGFLADKVGRKAVYTNSMLVYALGICLVLFGVNF PMLLSGYIIIGLSVGADITASWTIIAENAPKKNRARHCGVAQVAWAAGAVVVLLLSVL AGDLGLLGNKIVFAHLLVIALITYILRIRLPESDAWQTKNQPEEAQAEKPAVLNKTSY FDLLKPMYLKSILFLMGVYLVWNLAAGVMGFFMPYIYQQVGGVSANMANLLQMGLFIF TGLGVALIFMPFADKYRKTVFGIAAFMAVIGWTLFLLPVEGLPILLLFIVVIGINNGA GQQANYQLWASEIFPTQYRASAQGLMFFLVRISIGIWSLFVPMIITNFGIGTMAAILL GCVTASMIIGLLFAPNTSGKSLEQIQEELYGSPQSQVKKGTESKIM*" /label="iolF CDS" gene complement(3727956..3729272) /gene="iolF" /locus_tag="BSU_39710" /old_locus_tag="BSU39710" /label="iolF gene" CDS complement(3729287..3730180) /gene="iolE" /locus_tag="BSU_39720" /old_locus_tag="BSU39720" /EC_number="4.2.1.44" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9226270, 14993306, 22720735, 28693424" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9226270, 14993306, 22720735, 28693424; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="scyllo-inosose dehydratase" /protein_id="NP_391851.1" /db_xref="EnsemblGenomes-Gn:BSU39720" /db_xref="EnsemblGenomes-Tr:CAB16008" /db_xref="GOA:P42416" /db_xref="InterPro:IPR013022" /db_xref="InterPro:IPR023952" /db_xref="InterPro:IPR030823" /db_xref="InterPro:IPR036237" /db_xref="SubtiList:BG11121" /db_xref="UniProtKB/Swiss-Prot:P42416" /translation="MGKNEILWGIAPIGWRNDDMPEIGAGNTLQHLLSDIVVARFQGT EVGGFFPEPAILNKELKLRNLRIAGKWFSSFILRDGLGEAAKTFTLHCEYLQQVNADV AVVSEQTYSVQSLEKNVFTEKPHFTDDEWERLCEGLNHLGEIAAQHGLKLVYHHHLGT GVQTAEEVDRLMAGTDPAHVHLLYDTGHAYISDGDYMGMLEKHIGRIKHVHFKDARLN VMEQCRLEGQSFRQSFLKGMFTVPGDGCIDFREVYQLLLKHSYSGWIVIEAEQDPDVA NPLEYALIARNYIDQQLLDLA*" /label="iolE CDS" gene complement(3729287..3730180) /gene="iolE" /locus_tag="BSU_39720" /old_locus_tag="BSU39720" /label="iolE gene" CDS complement(3730197..3732110) /gene="iolD" /locus_tag="BSU_39730" /old_locus_tag="BSU39730" /EC_number="3.7.1.22" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9887260, 11566986, 12112707, 18310071, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9887260, 11566986, 12112707, 18310071, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="3D-(3,5/4)-trihydroxycyclohexane-1,2-dione hydrolase" /protein_id="NP_391852.2" /db_xref="EnsemblGenomes-Gn:BSU39730" /db_xref="EnsemblGenomes-Tr:CAB16009" /db_xref="GOA:P42415" /db_xref="InterPro:IPR000399" /db_xref="InterPro:IPR011766" /db_xref="InterPro:IPR012000" /db_xref="InterPro:IPR012001" /db_xref="InterPro:IPR023757" /db_xref="InterPro:IPR029035" /db_xref="InterPro:IPR029061" /db_xref="InterPro:IPR030817" /db_xref="SubtiList:BG11120" /db_xref="UniProtKB/Swiss-Prot:P42415" /translation="MGKKIRLTTAQALIKFLNQQYIHVDGKEEPFVEGIFTIFGHGNV LGIGQALEQDAGHLKVYQGKNEQGMAHAAMAYSKQMLRRKIYAVSTSVGPGAANLVAA AGTALANNIPVLLIPADTFATRQPDPVLQQMEQEYSAAITTNDALKPVSRYWDRITRP EQLMSSLLRAFEVMTDPAKAGPATICISQDVEGEAYDFDESFFVKRVHYIDRMQPSER ELQGAAELIKSSKKPVILVGGGAKYSGARDELVAISEAYNIPLVETQAGKSTVEADFA NNLGGMGITGTLAANKAARQADLIIGIGTRYTDFATSSKTAFDFDKAKFLNINVSRMQ AYKLDAFQVVADAKVTLGKLHGLLEGYESEFGTTIRELKDEWLAERERLSKVTFKREA FDPEIKNHFSQEVLNEYADALNTELPQTTALLTINETIPEDSVIICSAGSLPGDLQRL WHSNVPNTYHLEYGYSCMGYEVSGTLGLKLAHPDREVYSIVGDGSFLMLHSELITAIQ YNKKINVLLFDNSGFGCINNLQMDHGSGSYYCEFRTDDNQILNVDYAKVAEGYGAKTY RANTVEELKAALEDAKKQDVSTLIEMKVLPKTMTDGYDSWWHVGVAEVSEQESVQKAY EAKEKKLESAKQY*" /label="iolD CDS" gene complement(3730197..3732110) /gene="iolD" /locus_tag="BSU_39730" /old_locus_tag="BSU39730" /label="iolD gene" CDS complement(3732143..3733120) /gene="iolC" /locus_tag="BSU_39740" /old_locus_tag="BSU39740" /EC_number="2.7.1.92" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9887260, 11566986, 12112707, 18310071, 22720735, 23874669" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9887260, 11566986, 12112707, 18310071, 22720735, 23874669; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="2-deoxy-5-keto-D-gluconic acid kinase" /protein_id="NP_391853.1" /db_xref="EnsemblGenomes-Gn:BSU39740" /db_xref="EnsemblGenomes-Tr:CAB16010" /db_xref="GOA:P42414" /db_xref="InterPro:IPR002173" /db_xref="InterPro:IPR011611" /db_xref="InterPro:IPR022841" /db_xref="InterPro:IPR023314" /db_xref="InterPro:IPR029056" /db_xref="InterPro:IPR030830" /db_xref="SubtiList:BG11119" /db_xref="UniProtKB/Swiss-Prot:P42414" /translation="MKYTFNEEKAFDIVAIGRACIDLNAVEYNRPMEETMTFSKYVGG SPANIAIGSAKLGLKAGFIGKIPDDQHGRFIESYMRKTGVDTTQMIVDQDGHKAGLAF TEILSPEECSILMYRDDVADLYLEPSEVSEDYIANAKMLLVSGTALAKSPSREAVLKA VQYAKKHQVKVVFELDYRPYTWQSSDETAVYYSLVAEQSDIVIGTRDEFDVMENRTGG SNEESVNHLFGHSADLVVIKHGVEGSYAYSKSGEVFRAQAYKTKVLKTFGAGDSYASA FIYGLVSGKDIETALKYGSASASIVVSKHSSSEAMPTAEEIEQLIEAQS*" /label="iolC CDS" gene complement(3732143..3733120) /gene="iolC" /locus_tag="BSU_39740" /old_locus_tag="BSU39740" /label="iolC gene" CDS complement(3733144..3733959) /gene="iolB" /locus_tag="BSU_39750" /old_locus_tag="BSU39750" /EC_number="5.3.1.30" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:9887260, 11566986, 12112707, 18310071, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9887260, 11566986, 12112707, 18310071, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="5-deoxy-D-glucuronic acid isomerase" /protein_id="NP_391854.2" /db_xref="EnsemblGenomes-Gn:BSU39750" /db_xref="EnsemblGenomes-Tr:CAB16011" /db_xref="GOA:P42413" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR014710" /db_xref="InterPro:IPR021120" /db_xref="InterPro:IPR023770" /db_xref="InterPro:IPR024203" /db_xref="SubtiList:BG11118" /db_xref="UniProtKB/Swiss-Prot:P42413" /translation="MSYLLRKPQSHEVSNGVKLVHEVTTSNSDLTYVEFKVLDLASGS SYTEELKKQEICIVAVTGKITVTDHESTFENIGTRESVFERKPTDSVYISNDRAFEIT AVSDARVALCYSPSEKQLPTKLIKAEDNGIEHRGQFSNKRTVHNILPDSDPSANSLLV VEVYTDSGNWSSYPPHKHDQDNLPEESFLEETYYHELDPGQGFVFQRVYTDDRSIDET MTVGNENVVIVPAGYHPVGVPDGYTSYYLNVMAGPTRKWKFYNDPAHEWILER*" /label="iolB CDS" gene complement(3733144..3733959) /gene="iolB" /locus_tag="BSU_39750" /old_locus_tag="BSU39750" /label="iolB gene" S_feature complement(3733960..3734033) /Source="Nicolas_S_feature" /locus_tag="new_4082846_4082919_c" /HighExp="M40t90, M0t90, Lbtran, BI, Mt0, T0.30H, Sw, BC, S1, T1.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1525" CDS complement(3734034..3735497) /gene="iolA" /locus_tag="BSU_39760" /old_locus_tag="BSU39760" /EC_number="1.2.1.27" /EC_number="1.2.1.18" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:10658656, 11566986, 16332250, 18310071, 20971862, 22720735, 26832667" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10658656, 11566986, 16332250, 18310071, 20971862, 22720735, 26832667; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="methylmalonate-semialdehyde dehydrogenase" /protein_id="NP_391855.1" /db_xref="EnsemblGenomes-Gn:BSU39760" /db_xref="EnsemblGenomes-Tr:CAB16012" /db_xref="GOA:P42412" /db_xref="InterPro:IPR010061" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016160" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR023510" /db_xref="PDB:1T90" /db_xref="SubtiList:BG11117" /db_xref="UniProtKB/Swiss-Prot:P42412" /translation="MAEIRKLKNYINGEWVESKTDQYEDVVNPATKEVLCQVPISTKE DIDYAAQTAAEAFKTWSKVAVPRRARILFNFQQLLSQHKEELAHLITIENGKNTKEAL GEVGRGIENVEFAAGAPSLMMGDSLASIATDVEAANYRYPIGVVGGIAPFNFPMMVPC WMFPMAIALGNTFILKPSERTPLLTEKLVELFEKAGLPKGVFNVVYGAHDVVNGILEH PEIKAISFVGSKPVGEYVYKKGSENLKRVQSLTGAKNHTIVLNDANLEDTVTNIVGAA FGSAGERCMACAVVTVEEGIADEFMAKLQEKVADIKIGNGLDDGVFLGPVIREDNKKR TLSYIEKGLEEGARLVCDGRENVSDDGYFVGPTIFDNVTTEMTIWKDEIFAPVLSVIR VKNLKEAIEIANKSEFANGACLFTSNSNAIRYFRENIDAGMLGINLGVPAPMAFFPFS GWKSSFFGTLHANGKDSVDFYTRKKVVTARYPAPDFN*" /label="iolA CDS" gene complement(3734034..3735497) /gene="iolA" /locus_tag="BSU_39760" /old_locus_tag="BSU39760" /label="iolA gene" S_feature complement(3735498..3735702) /Source="Nicolas_S_feature" /locus_tag="new_4084384_4084588_c" /HighExp="M0t90, M40t90, Lbtran, BI, Mt0, T0.30H, BC, S1, T1.0H, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1526" promotor_-35 3735501..3735508 /Source="Nicolas_upshift_promotors" /id="U3125" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.626373626373626" /psig="0.788211788211788" /xcortree=1805 /SigmaFactorBS="gttttttaattttctgatttctgccattctTATTGCCTcctt cattagtaaacACATACACTTGTATGGATGGttccggatagattcatatcaatatcca c" /listShort="S1527" /listLong="iolR, iolS" /label="promotor_-35" promotor_-10 3735524..3735543 /Source="Nicolas_upshift_promotors" /id="U3125" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.626373626373626" /psig="0.788211788211788" /xcortree=1805 /SigmaFactorBS="gttttttaattttctgatttctgccattctTATTGCCTcctt cattagtaaacACATACACTTGTATGGATGGttccggatagattcatatcaatatcca c" /listShort="S1527" /listLong="iolR, iolS" /label="promotor_-10" upshifts 3735531 /Source="Nicolas_upshifts" /id="U3125" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.626373626373626" /psig="0.788211788211788" /xcortree=1805 /SigmaFactorBS="gttttttaattttctgatttctgccattctTATTGCCTcctt cattagtaaacACATACACTTGTATGGATGGttccggatagattcatatcaatatcca c" /listShort="S1527" /listLong="iolR, iolS" /label="upshifts" S_feature 3735538..3735844 /Source="Nicolas_S_feature" /locus_tag="new_4084424_4084730" /HighExp="G180, Paraq, G150, Oxctl, H2O2, G135, Diami, LBGexp, dia5, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.788" /TUlongSig="NA" /TUlongPSig="NA" /label="S1527" promotor_-10 complement(3735684..3735703) /Source="Nicolas_upshift_promotors" /id="U3126" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=331 /SigmaFactorBS="taatataataaaaataatgaaaaaatgtagtgtttatGATTG ACTtatgggtattatgcGATTAGAATATAACCAAGAAatgaccaaaaagtaacctgtt g" /listShort="S1526, mmsA, S1525, iolB, iolC, iolD, iolE, iolF, iolG, iolH, S1524, iolI, iolJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3735702) /Source="Nicolas_upshifts" /id="U3126" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=331 /SigmaFactorBS="taatataataaaaataatgaaaaaatgtagtgtttatGATTG ACTtatgggtattatgcGATTAGAATATAACCAAGAAatgaccaaaaagtaacctgtt g" /listShort="S1526, mmsA, S1525, iolB, iolC, iolD, iolE, iolF, iolG, iolH, S1524, iolI, iolJ" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3735704..3735856) /Source="Nicolas_S_feature" /locus_tag="new_4084590_4084742_c" /HighExp="M40t90, M0t90, Lbtran, Diami, Heat, dia5, C30, BI, S1, Mt0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1528" promotor_-35 complement(3735718..3735725) /Source="Nicolas_upshift_promotors" /id="U3126" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=331 /SigmaFactorBS="taatataataaaaataatgaaaaaatgtagtgtttatGATTG ACTtatgggtattatgcGATTAGAATATAACCAAGAAatgaccaaaaagtaacctgtt g" /listShort="S1526, mmsA, S1525, iolB, iolC, iolD, iolE, iolF, iolG, iolH, S1524, iolI, iolJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3735804..3735811 /Source="Nicolas_upshift_promotors" /id="U3127" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.95004995004995" /psig="0.99000999000999" /xcortree=329 /SigmaFactorBS="taagagaaggccgtccaaTCTTGCAAaagatatacaccgaTG TTATCATTTTTAAGCAACtattgattaacttttggtttttattatatatttatgttac g" /listShort="iolR, iolS" /listLong="S1529, yxcE, yxcD" /label="promotor_-35" promotor_-10 3735826..3735845 /Source="Nicolas_upshift_promotors" /id="U3127" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.95004995004995" /psig="0.99000999000999" /xcortree=329 /SigmaFactorBS="taagagaaggccgtccaaTCTTGCAAaagatatacaccgaTG TTATCATTTTTAAGCAACtattgattaacttttggtttttattatatatttatgttac g" /listShort="iolR, iolS" /listLong="S1529, yxcE, yxcD" /label="promotor_-10" upshifts 3735846 /Source="Nicolas_upshifts" /id="U3127" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.95004995004995" /psig="0.99000999000999" /xcortree=329 /SigmaFactorBS="taagagaaggccgtccaaTCTTGCAAaagatatacaccgaTG TTATCATTTTTAAGCAACtattgattaacttttggtttttattatatatttatgttac g" /listShort="iolR, iolS" /listLong="S1529, yxcE, yxcD" /label="upshifts" promotor_-10 complement(3735857..3735876) /Source="Nicolas_upshift_promotors" /id="U3128" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.861138861138861" /psig=1 /xcortree=332 /SigmaFactorBS="ctgaatccgcatcagtttcatataaaaaactcctTCTTGAAT ctttacgtaacataaATATATAATAAAAACCAAAAgttaatcaatagttgcttaaaaa t" /listShort="S1528" /listLong="S1526, mmsA, S1525, iolB, iolC, iolD, iolE, iolF, iolG, iolH, S1524, iolI, iolJ" /label="promotor_-10" upshifts complement(3735873) /Source="Nicolas_upshifts" /id="U3128" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.861138861138861" /psig=1 /xcortree=332 /SigmaFactorBS="ctgaatccgcatcagtttcatataaaaaactcctTCTTGAAT ctttacgtaacataaATATATAATAAAAACCAAAAgttaatcaatagttgcttaaaaa t" /listShort="S1528" /listLong="S1526, mmsA, S1525, iolB, iolC, iolD, iolE, iolF, iolG, iolH, S1524, iolI, iolJ" /label="upshifts" promotor_-35 complement(3735892..3735899) /Source="Nicolas_upshift_promotors" /id="U3128" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.861138861138861" /psig=1 /xcortree=332 /SigmaFactorBS="ctgaatccgcatcagtttcatataaaaaactcctTCTTGAAT ctttacgtaacataaATATATAATAAAAACCAAAAgttaatcaatagttgcttaaaaa t" /listShort="S1528" /listLong="S1526, mmsA, S1525, iolB, iolC, iolD, iolE, iolF, iolG, iolH, S1524, iolI, iolJ" /label="promotor_-35" CDS 3735913..3736668 /gene="iolR" /locus_tag="BSU_39770" /old_locus_tag="BSU39770" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9887260, 11566986, 11807058, 18310071, 24878601, 26735940" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9887260, 11566986, 11807058, 18310071, 24878601, 26735940; Product type r : regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of the iol operon (DeoR family)" /protein_id="NP_391856.1" /db_xref="EnsemblGenomes-Gn:BSU39770" /db_xref="EnsemblGenomes-Tr:CAB16013" /db_xref="GOA:P46337" /db_xref="InterPro:IPR001034" /db_xref="InterPro:IPR014036" /db_xref="InterPro:IPR018356" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11364" /db_xref="UniProtKB/Swiss-Prot:P46337" /translation="MKLMRIQEMEEYILSHGTVSLDELCQVFNVSKNTVRRDINKLTE KGAIEKVYGGVTSIEKTALVPFENRTIQHQDEKTKIAHYASRFIEDHDLVFIDSGTTT KSILDTLDPAKNVTILTNSLDIINAASALKNINLIIIGNNYKRKTRSFVGMDDPAMLD KYNINKAFMSATGTTLTHGLTNSDLLEYEIKKRISEKAKEVYLLADHSKFGKSTLLTY APFDRLHCIVTSQPLDDEYTQYCNEHQIGIHLA*" /label="iolR CDS" gene 3735913..3736668 /gene="iolR" /locus_tag="BSU_39770" /old_locus_tag="BSU39770" /label="iolR gene" promotor_-35 3736647..3736653 /Source="Nicolas_upshift_promotors" /id="U3129" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.841158841158841" /psig="0.994005994005994" /xcortree=2059 /SigmaFactorBS="acacgcagtactgcaatgagcatcaAATCGGCattcatctgg cctaACGTTTACAATAGTGTTGAGagtctatcatccattttattctaggaggcagatc a" /listShort="iolS, S1529, yxcE, yxcD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3736668..3736687 /Source="Nicolas_upshift_promotors" /id="U3129" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.841158841158841" /psig="0.994005994005994" /xcortree=2059 /SigmaFactorBS="acacgcagtactgcaatgagcatcaAATCGGCattcatctgg cctaACGTTTACAATAGTGTTGAGagtctatcatccattttattctaggaggcagatc a" /listShort="iolS, S1529, yxcE, yxcD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3736682 /Source="Nicolas_upshifts" /id="U3129" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.841158841158841" /psig="0.994005994005994" /xcortree=2059 /SigmaFactorBS="acacgcagtactgcaatgagcatcaAATCGGCattcatctgg cctaACGTTTACAATAGTGTTGAGagtctatcatccattttattctaggaggcagatc a" /listShort="iolS, S1529, yxcE, yxcD" /GFF_Attribute="listLong" /label="upshifts" CDS 3736722..3737654 /gene="iolS" /locus_tag="BSU_39780" /old_locus_tag="BSU39780" /EC_number="1.1.1.-" /function="16.11: Scavenge (Catabolism)" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9226270, 15019785, 22720735, 24330391; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aldo-keto reductase" /protein_id="NP_391857.1" /db_xref="EnsemblGenomes-Gn:BSU39780" /db_xref="EnsemblGenomes-Tr:CAB16014" /db_xref="GOA:P46336" /db_xref="InterPro:IPR018170" /db_xref="InterPro:IPR020471" /db_xref="InterPro:IPR023210" /db_xref="InterPro:IPR036812" /db_xref="PDB:1PYF" /db_xref="PDB:1PZ0" /db_xref="SubtiList:BG11363" /db_xref="UniProtKB/Swiss-Prot:P46336" /translation="MKKAKLGKSDLQVFPIGLGTNAVGGHNLYPNLNEETGKELVREA IRNGVTMLDTAYIYGIGRSEELIGEVLREFNREDVVIATKAAHRKQGNDFVFDNSPDF LKKSVDESLKRLNTDYIDLFYIHFPDEHTPKDEAVNALNEMKKAGKIRSIGVSNFSLE QLKEANKDGLVDVLQGEYNLLNREAEKTFFPYTKEHNISFIPYFPLVSGLLAGKYTED TTFPEGDLRNEQEHFKGERFKENIRKVNKLAPIAEKHNVDIPHIVLAWYLARPEIDIL IPGAKRADQLIDNIKTADVTLSQEDISFIDKLFA*" /label="iolS CDS" gene 3736722..3737654 /gene="iolS" /locus_tag="BSU_39780" /old_locus_tag="BSU39780" /label="iolS gene" downshifts 3737656 /Source="Nicolas_upshifts" /id="D2054" /incds=0 /nref=154 /ntot=259 /MaxReadThrough="4.521" /MaxDrop="7.17874" /score="39.70215" /energy="-17.1" /TU="U3129" /idTUdmin="U3127" /TUdmin=6 /isTUend="TRUE" /label="downshifts" promotor_-35 3737733..3737740 /Source="Nicolas_upshift_promotors" /id="U3130" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.703296703296703" /psig="0.835164835164835" /xcortree=2016 /SigmaFactorBS="ataaattcctaaataactgattttgaagcaaaaCCTTACAAa atgagccataaaTCCGATAAAATAAAGGTAGTttatctcagaaagaaagtgattgaga a" /listShort="S1529, yxcE, yxcD" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3737754..3737773 /Source="Nicolas_upshift_promotors" /id="U3130" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.703296703296703" /psig="0.835164835164835" /xcortree=2016 /SigmaFactorBS="ataaattcctaaataactgattttgaagcaaaaCCTTACAAa atgagccataaaTCCGATAAAATAAAGGTAGTttatctcagaaagaaagtgattgaga a" /listShort="S1529, yxcE, yxcD" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3737760..3737915 /Source="Nicolas_S_feature" /locus_tag="new_4086646_4086801" /HighExp="dia5, LPhT, Diami, Etha, dia15, LBGstat, M9-stat, Lbtran, T0.30H, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.835, 0.994" /TUlongSig="SigA" /TUlongPSig="0.99" /label="S1529" upshifts 3737760 /Source="Nicolas_upshifts" /id="U3130" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.703296703296703" /psig="0.835164835164835" /xcortree=2016 /SigmaFactorBS="ataaattcctaaataactgattttgaagcaaaaCCTTACAAa atgagccataaaTCCGATAAAATAAAGGTAGTttatctcagaaagaaagtgattgaga a" /listShort="S1529, yxcE, yxcD" /GFF_Attribute="listLong" /label="upshifts" CDS 3737916..3738566 /gene="yxcE" /locus_tag="BSU_39790" /old_locus_tag="BSU39790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391858.1" /db_xref="EnsemblGenomes-Gn:BSU39790" /db_xref="EnsemblGenomes-Tr:CAB16015" /db_xref="GOA:P46335" /db_xref="SubtiList:BG11362" /db_xref="UniProtKB/Swiss-Prot:P46335" /translation="MKLKYVKALVAVTVALGVLLPSTISHAKSFSGRSSSSYSSRSSS SSYSGSYKSSPKSSYSSGSSSSSKKSKTSDDSSSSISLKKKPSEKASSSSSKKSSGTF SGATSKVTGKTYSGKTSKAYVGGRYVSVNHYYHAGFAPSGWFGYYSGFTMGMFMISMM HPWGYTYHPVGGPGYVSYGASPIAWIVDIIALIIILIIVIALIRAFKAPKTYRRRF*" /label="yxcE CDS" gene 3737916..3738566 /gene="yxcE" /locus_tag="BSU_39790" /old_locus_tag="BSU39790" /label="yxcE gene" CDS 3738570..3738878 /gene="yxcD" /locus_tag="BSU_39800" /old_locus_tag="BSU39800" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391859.1" /db_xref="EnsemblGenomes-Gn:BSU39800" /db_xref="EnsemblGenomes-Tr:CAB16016" /db_xref="InterPro:IPR020516" /db_xref="SubtiList:BG11361" /db_xref="UniProtKB/Swiss-Prot:P46334" /translation="MRLILNEQEIVDGICVYISNEEDIYPEDVEVKELSYNKRTGFFA EATFGLHHKQLMSDDISEGIIQFLEEYHNFNPDVTVVELQFDKKKGFSALVFVNEAEE *" /label="yxcD CDS" gene 3738570..3738878 /gene="yxcD" /locus_tag="BSU_39800" /old_locus_tag="BSU39800" /label="yxcD gene" downshifts 3738880 /Source="Nicolas_upshifts" /id="D2055" /incds=0 /nref=185 /ntot=262 /MaxReadThrough="1.91541" /MaxDrop="6.4314" /score="14.1581732" /energy="-8.8" /TU="NA" /idTUdmin="U3130" /TUdmin="-2" /isTUend="TRUE" /label="downshifts" promotor_-35 3739022..3739028 /Source="Nicolas_upshift_promotors" /id="U3131" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=218 /SigmaFactorBS="tataaagtttccgttttttcaaaacaaaTGTTTCAaatgaga taggaaatGGGTACTAATCTATTAACTttgttacatatttttagatactcattggctc a" /listShort="csbC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3739044..3739062 /Source="Nicolas_upshift_promotors" /id="U3131" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=218 /SigmaFactorBS="tataaagtttccgttttttcaaaacaaaTGTTTCAaatgaga taggaaatGGGTACTAATCTATTAACTttgttacatatttttagatactcattggctc a" /listShort="csbC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3739054 /Source="Nicolas_upshifts" /id="U3131" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=218 /SigmaFactorBS="tataaagtttccgttttttcaaaacaaaTGTTTCAaatgaga taggaaatGGGTACTAATCTATTAACTttgttacatatttttagatactcattggctc a" /listShort="csbC" /GFF_Attribute="listLong" /label="upshifts" CDS 3739116..3740501 /gene="csbC" /locus_tag="BSU_39810" /old_locus_tag="BSU39810" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10376822, 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative metabolite transporter" /protein_id="NP_391860.1" /db_xref="EnsemblGenomes-Gn:BSU39810" /db_xref="EnsemblGenomes-Tr:CAB16017" /db_xref="GOA:P46333" /db_xref="InterPro:IPR003663" /db_xref="InterPro:IPR005828" /db_xref="InterPro:IPR005829" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11360" /db_xref="UniProtKB/Swiss-Prot:P46333" /translation="MKKDTRKYMIYFFGALGGLLYGYDTGVISGALLFINNDIPLTTL TEGLVVSMLLLGAIFGSALSGTCSDRWGRRKVVFVLSIIFIIGALACAFSQTIGMLIA SRVILGLAVGGSTALVPVYLSEMAPTKIRGTLGTMNNLMIVTGILLAYIVNYLFTPFE AWRWMVGLAAVPAVLLLIGIAFMPESPRWLVKRGSEEEARRIMNITHDPKDIEMELAE MKQGEAEKKETTLGVLKAKWIRPMLLIGVGLAIFQQAVGINTVIYYAPTIFTKAGLGT SASALGTMGIGILNVIMCITAMILIDRVGRKKLLIWGSVGITLSLAALSGVLLTLGLS ASTAWMTVVFLGVYIVFYQATWGPVVWVLMPELFPSKARGAATGFTTLVLSAANLIVS LVFPLMLSAMGIAWVFMVFSVICLLSFFFAFYMVPETKGKSLEEIEASLKKRFKKKKS TQNQVLNERTL*" /label="csbC CDS" gene 3739116..3740501 /gene="csbC" /locus_tag="BSU_39810" /old_locus_tag="BSU39810" /label="csbC gene" downshifts 3740487 /Source="Nicolas_upshifts" /id="D2056" /incds=0 /nref=69 /ntot=115 /MaxReadThrough="4.59405" /MaxDrop="7.32264" /score="22.9943012" /energy="-16.4" /TU="NA" /idTUdmin="U3131" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature 3740532..3741082 /Source="Nicolas_S_feature" /locus_tag="new_4089418_4089968" /HighExp="Etha, C30, C90, Gly, Sw, G135, Fru, HiTm, M/G, Mal" /AntisenseName="htpG" /AntisenseCor="7.4766600377621104E-2" /AntisenseRegPval="-0.7" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1530" CDS complement(3740543..3742423) /gene="htpG" /locus_tag="BSU_39820" /old_locus_tag="BSU39820" /function="16.6: Maintain" /experiment="publication(s) with functional evidences, PMID:9150201, 10323241, 11407116, 12511492, 22226636, 26743745, 27723736, 28363677, 28383119, 28784328" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9150201, 10323241, 11407116, 12511492, 22226636, 26743745, 27723736, 28363677, 28383119, 28784328; Product type f: factor" /codon_start=1 /transl_table=11 /product="class III heat-shock protein (ATP-dependent molecular chaperone HSP90)" /protein_id="NP_391861.1" /db_xref="EnsemblGenomes-Gn:BSU39820" /db_xref="EnsemblGenomes-Tr:CAB16018" /db_xref="GOA:P46208" /db_xref="InterPro:IPR001404" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR019805" /db_xref="InterPro:IPR020568" /db_xref="InterPro:IPR020575" /db_xref="InterPro:IPR036890" /db_xref="InterPro:IPR037196" /db_xref="SubtiList:BG11359" /db_xref="UniProtKB/Swiss-Prot:P46208" /translation="MAKKEFKAESKRLLDMMINSIYTQKEIFLRELISNSSDAIDKIY YKALTDDALTFDKDSYYIKVAADKDARTLTISDTGIGMTKDELEQHLGTIAKSGSLAF KKENELKDGHDIIGQFGVGFYAAFMVADVVTVISKALGSEEAYKWESAGADGYTIEPC EKDSVGTDIILKIKENTEDDSYDEFLEEYRLKAIIKKYSDFIRYPIKMDTTINKPKEG SENEFEEVQEEQTVNSMVPIWRKNKSELTDEDYEKFYAEKHYGFDKPLTHVHISVDGA VRYNAILFVPENMPFDYYSKEYEKGLELYSNGVLIMNKCADLLPDHFSFVKGMVDSED LSLNISREMLQHDRQLKLIAKNISKKIKSELQSLLKKDREKYETFYKSFGRQLKFGVY NDFGANKDQLKDLLLFYSSKEKKLVSLDEYVSRMPEEQKFIYYATGDSYDRIEKLPQT EMVADKGYEILYFTEDIDEFAIKMLASYQEKEFKSVSSGDLGIDTDEDQKQSEEEESK YKDLFEEMKNILSDKVKNVRISKRLKSHPVCLAADGEVTIEMEKILNAMPDSQNVKAE KVLEINPNHEVFQTLQDAFEQDKEKLSLYTNLLYNQALLIEGLPIQDPVEFTNNICKV MV*" /label="htpG CDS" gene complement(3740543..3742423) /gene="htpG" /locus_tag="BSU_39820" /old_locus_tag="BSU39820" /label="htpG gene" downshifts complement(3740549) /Source="Nicolas_upshifts" /id="D2057" /incds=0 /nref=169 /ntot=288 /MaxReadThrough="0.81611" /MaxDrop="6.49379" /score="34.0973015" /energy="-16.4" /TU="NA" /idTUdmin="U3132" /TUdmin="-8" /isTUend="TRUE" /label="downshifts" S_feature complement(3742424..3742521) /Source="Nicolas_S_feature" /locus_tag="new_4091310_4091407_c" /HighExp="Lbtran, S1, LBGtran, C90, M40t45, M9-tran, GM 150, dia0, T-2.40H, dia5" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="SigA" /TUlongPSig="0.995" /label="S1531" promotor_-10 complement(3742512..3742531) /Source="Nicolas_upshift_promotors" /id="U3132" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.69030969030969" /psig="0.996003996003996" /xcortree=2301 /SigmaFactorBS="tcttttttatgagaatgagtgagaaaaaGAGTGAAAacaaat ccaactaaTGTTAAATTTACATATATATgcatctatcaatctaattgacaattgtcat c" /listShort="S1531, htpG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3742521) /Source="Nicolas_upshifts" /id="U3132" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.69030969030969" /psig="0.996003996003996" /xcortree=2301 /SigmaFactorBS="tcttttttatgagaatgagtgagaaaaaGAGTGAAAacaaat ccaactaaTGTTAAATTTACATATATATgcatctatcaatctaattgacaattgtcat c" /listShort="S1531, htpG" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3742546..3742553) /Source="Nicolas_upshift_promotors" /id="U3132" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.69030969030969" /psig="0.996003996003996" /xcortree=2301 /SigmaFactorBS="tcttttttatgagaatgagtgagaaaaaGAGTGAAAacaaat ccaactaaTGTTAAATTTACATATATATgcatctatcaatctaattgacaattgtcat c" /listShort="S1531, htpG" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3742591..3742842) /gene="yxcA" /locus_tag="BSU_39830" /old_locus_tag="BSU39830" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391862.1" /db_xref="EnsemblGenomes-Gn:BSU39830" /db_xref="EnsemblGenomes-Tr:CAB16019" /db_xref="GOA:P46332" /db_xref="SubtiList:BG11358" /db_xref="UniProtKB/Swiss-Prot:P46332" /translation="MKVQHKKELKFYCIVTIPSAFVVLTVISFLLQEITFPVTASAFL NASWHNLLFLIPFGLFFYPVHIWMKREFGRWNDTEKKRG*" /label="yxcA CDS" gene complement(3742591..3742842) /gene="yxcA" /locus_tag="BSU_39830" /old_locus_tag="BSU39830" /label="yxcA gene" downshifts complement(3742609) /Source="Nicolas_upshifts" /id="D2058" /incds=0 /nref=11 /ntot=62 /MaxReadThrough="3.50049" /MaxDrop="5.56962" /score="-3.89567108" /energy="-6.7" /TU="U3133" /idTUdmin="U3133" /TUdmin="-66" /isTUend="FALSE" /label="downshifts" misc_feature complement(3742864..3742883) /Source="Nicolas_upshift_promotors" /id="U3133" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.928071928071928" /psig="0.995004995004995" /xcortree=2181 /SigmaFactorBS="gtcttcccgctatgtgcagtgataaacatgcgagaaaagaaa ggccagcaTATGTTAAGATGAATTAGAAattgttgggaggtttgtatgtttgaaggta c" /listShort="yxcA" /listLong="S1531, htpG" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3742873) /Source="Nicolas_upshifts" /id="U3133" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.928071928071928" /psig="0.995004995004995" /xcortree=2181 /SigmaFactorBS="gtcttcccgctatgtgcagtgataaacatgcgagaaaagaaa ggccagcaTATGTTAAGATGAATTAGAAattgttgggaggtttgtatgtttgaaggta c" /listShort="yxcA" /listLong="S1531, htpG" /label="upshifts" promotor_-35 3742906..3742912 /Source="Nicolas_upshift_promotors" /id="U3134" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=245 /SigmaFactorBS="taattcatcttaacatatgctggcctttcttttctcgcaTGT TTATcactgcacatagcGGGAAGACAAATAGAAAAAggaggtctcgtatcatgggaag a" /listShort="yxbG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3742926..3742944 /Source="Nicolas_upshift_promotors" /id="U3134" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=245 /SigmaFactorBS="taattcatcttaacatatgctggcctttcttttctcgcaTGT TTATcactgcacatagcGGGAAGACAAATAGAAAAAggaggtctcgtatcatgggaag a" /listShort="yxbG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3742927 /Source="Nicolas_upshifts" /id="U3134" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=245 /SigmaFactorBS="taattcatcttaacatatgctggcctttcttttctcgcaTGT TTATcactgcacatagcGGGAAGACAAATAGAAAAAggaggtctcgtatcatgggaag a" /listShort="yxbG" /GFF_Attribute="listLong" /label="upshifts" CDS 3742959..3743780 /gene="yxbG" /locus_tag="BSU_39840" /old_locus_tag="BSU39840" /EC_number="1.-.-.-" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 10746760; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391863.2" /db_xref="EnsemblGenomes-Gn:BSU39840" /db_xref="EnsemblGenomes-Tr:CAB16020" /db_xref="GOA:P46331" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11357" /db_xref="UniProtKB/Swiss-Prot:P46331" /translation="MGRLENKTAVITGAATGIGQATAEVFANEGARVIIGDINKDQME ETVDAIRKNGGQAESFHLDVSDENSVKAFADQIKDACGTIDILFNNAGVDQEGGKVHE YPVDLFDRIIAVDLRGTFLCSKYLIPLMLENGGSIINTSSMSGRAADLDRSGYNAAKG GITNLTKAMAIDYARNGIRVNSISPGTIETPLIDKLAGTKEQEMGEQFREANKWITPL GRLGQPKEMATVALFLASDDSSYVTGEDITADGGIMAYTWPGKMLIEEKWKEETK*" /label="yxbG CDS" gene 3742959..3743780 /gene="yxbG" /locus_tag="BSU_39840" /old_locus_tag="BSU39840" /label="yxbG gene" downshifts 3743764 /Source="Nicolas_upshifts" /id="D2059" /incds=0 /nref=22 /ntot=67 /MaxReadThrough="2.87575" /MaxDrop="5.67438" /score="22.9485028" /energy="-10.5" /TU="U3134" /idTUdmin="U3134" /TUdmin="-221" /isTUend="FALSE" /label="downshifts" CDS complement(3743809..3744951) /gene="yxbF" /locus_tag="BSU_39850" /old_locus_tag="BSU39850" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11160890; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator" /protein_id="NP_391864.1" /db_xref="EnsemblGenomes-Gn:BSU39850" /db_xref="EnsemblGenomes-Tr:CAB16021" /db_xref="GOA:P46330" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="SubtiList:BG11356" /db_xref="UniProtKB/Swiss-Prot:P46330" /translation="MPESAEAQVKEALLALLKDRDIQHITMKEIAEKAKVSRGSLYLY YEDKFSIIEDVIEDMKEGLGKALFDAFSHMDTLHLNKKRQTVHPTLSFVHEHRSFFSV MMNRGHFHRFFKDVFQQDVLLAPIHVNLTPIERDIYGHYRALYTYAIILYWLNEDAAA SPEAISQKVWELVSQKRFYWLFGKAVPGEREKEKQIDRRVVRTREALQKAFLDVLAEK QDYAGITISDITRKSNIRRATFYDHYANKEELLQTMIQRSCAEIIDHLTIASSPNEFS LKEAEKALAILLSALSNMPIVHFLNREWGVPHVIPDMFKALESFYLHQQTDIHAEKKL YAHYVSAMIIGLLLYRLDEGKAHPPEVLAREFLQFLDVKKYKVVLL*" /label="yxbF CDS" gene complement(3743809..3744951) /gene="yxbF" /locus_tag="BSU_39850" /old_locus_tag="BSU39850" /label="yxbF gene" downshifts complement(3743819) /Source="Nicolas_upshifts" /id="D2060" /incds=0 /nref=10 /ntot=163 /MaxReadThrough="1.63217" /MaxDrop="3.79969" /score="-0.564494299" /energy="-10.5" /TU="NA" /idTUdmin="U3135" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(3744952..3745051) /Source="Nicolas_S_feature" /locus_tag="new_4093838_4093937_c" /HighExp="H2O2, Diami, dia15, Paraq, G180, G135, G150, dia5, Oxctl, LBGexp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1532" promotor_-10 complement(3745039..3745058) /Source="Nicolas_upshift_promotors" /id="U3135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.926073926073926" /psig="0.997002997002997" /xcortree=1836 /SigmaFactorBS="tttacttgctgttccattgtaaaatccccctCATTTGCTttc ttcttttctcGGACCTATTATAAGGTGGTAccttttctgtaagaaagacaacggtgaa c" /listShort="S1532, yxbF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3745050) /Source="Nicolas_upshifts" /id="U3135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.926073926073926" /psig="0.997002997002997" /xcortree=1836 /SigmaFactorBS="tttacttgctgttccattgtaaaatccccctCATTTGCTttc ttcttttctcGGACCTATTATAAGGTGGTAccttttctgtaagaaagacaacggtgaa c" /listShort="S1532, yxbF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3745072..3745079) /Source="Nicolas_upshift_promotors" /id="U3135" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.926073926073926" /psig="0.997002997002997" /xcortree=1836 /SigmaFactorBS="tttacttgctgttccattgtaaaatccccctCATTTGCTttc ttcttttctcGGACCTATTATAAGGTGGTAccttttctgtaagaaagacaacggtgaa c" /listShort="S1532, yxbF" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3745094..3746431 /gene="aldX" /locus_tag="BSU_39860" /old_locus_tag="BSU39860" /EC_number="1.2.1.3" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative aldehyde dehydrogenase" /protein_id="NP_391865.2" /db_xref="EnsemblGenomes-Gn:BSU39860" /db_xref="EnsemblGenomes-Tr:CAB16022" /db_xref="GOA:P46329" /db_xref="InterPro:IPR012394" /db_xref="InterPro:IPR015590" /db_xref="InterPro:IPR016160" /db_xref="InterPro:IPR016161" /db_xref="InterPro:IPR016162" /db_xref="InterPro:IPR029510" /db_xref="SubtiList:BG11355" /db_xref="UniProtKB/Swiss-Prot:P46329" /translation="MEQQVKDDIQRVFQLQKKQQKALRASTAEQRREKLQRFLDSVIA HEEEIIEAIRKDVRKPYHEVKKAEIEGTKKAIRDNMNNLEQWMAPKEVGSSLSPDANG ILMYEPKGVTLILGPWNYPFMLTMAPLAASLAAGNSAIVKLSDFTMNTSNIAAKVIRD AFDEKEVAIFEGEVEVATELLDQPFDHIFFTGSTNVGKIVMTAAAKHLASVTLELGGK SPTIIDSEYDLMDAAKKIAVGKFVNAGQTCIAPDYLFIKKDVQDRFAGILQTVVNAGF MEDDHTPDRSKFTQIVNDRNFNRVKDLFDDAIERGAEVVFGGVFDASDRTISPTVLKN VTPDMKIMQEEIFASILPMMNYEDIDEVIDYVNDRDKPLALYVFSKNQDLIDNVLQHT TSGNAAINDVVVHFSDVNLPFGGVNTSGIGSYHGVYGFKEFSHEKGVFIQAAE*" /label="aldX CDS" gene 3745094..3746431 /gene="aldX" /locus_tag="BSU_39860" /old_locus_tag="BSU39860" /label="aldX gene" S_feature complement(3745836..3746436) /Source="Nicolas_S_feature" /locus_tag="new_4094722_4095322_c" /HighExp="T1.30H, T2.30H, T2.0H, T1.0H, T-2.40H, T3.0H, T3.30H, T0.0H, T-0.40H, T-3.40H" /AntisenseName="aldX" /AntisenseCor="-0.39894728806999702" /AntisenseRegPval="-11" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1533" CDS complement(3746470..3746949) /gene="yxbD" /locus_tag="BSU_39870" /old_locus_tag="BSU39870" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_391866.2" /db_xref="EnsemblGenomes-Gn:BSU39870" /db_xref="EnsemblGenomes-Tr:CAB16023" /db_xref="GOA:P46328" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG11354" /db_xref="UniProtKB/Swiss-Prot:P46328" /translation="MNIIPTCQVPKDLVSAFFQKHWGSPQMVISSGIYNCDELDGYGM LNDDNQIVGLITYIFEEDACEIISLDSVIENKGIGTALLEKAEEACRERNIKQIKLIT TNDNIHALAFYQKRGYRLDRLFVNAVETARKMKPEIPLLADNKIPIRDELLLVKELQ* " /label="yxbD CDS" gene complement(3746470..3746949) /gene="yxbD" /locus_tag="BSU_39870" /old_locus_tag="BSU39870" /label="yxbD gene" downshifts complement(3746481) /Source="Nicolas_upshifts" /id="D2061" /incds=0 /nref=1 /ntot=39 /MaxReadThrough="3.82941" /MaxDrop="2.52984" /score="-7.41869067" /energy="-10.9" /TU="U3136" /idTUdmin="U3136" /TUdmin="-616" /isTUend="FALSE" /label="downshifts" CDS complement(3747029..3748021) /gene="yxbC" /locus_tag="BSU_39880" /old_locus_tag="BSU39880" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391867.1" /db_xref="EnsemblGenomes-Gn:BSU39880" /db_xref="EnsemblGenomes-Tr:CAB16024" /db_xref="GOA:P46327" /db_xref="InterPro:IPR003347" /db_xref="PDB:1VRB" /db_xref="SubtiList:BG11353" /db_xref="UniProtKB/Swiss-Prot:P46327" /translation="MSAVTESVLESIISPVTMSEFLEEYWPVKPLVARGEVERFTSIP GFEKVRTLENVLAIYNNPVMVVGDAVIEESEGITDRFLVSPAEALEWYEKGAALEFDF TDLFIPQVRRWIEKLKAELRLPAGTSSKAIVYAAKNGGGFKAHFDAYTNLIFQIQGEK TWKLAKNENVSNPMQHYDLSEAPYYPDDLQSYWKGDPPKEDLPDAEIVNLTPGTMLYL PRGLWHSTKSDQATLALNITFGQPAWLDLMLAALRKKLISDNRFRELAVNHQSLHESS KSELNGYLESLIQTLSENAETLTPEQIFQSQDSDFDPYQSTQLVFRQLLTSYKF*" /label="yxbC CDS" gene complement(3747029..3748021) /gene="yxbC" /locus_tag="BSU_39880" /old_locus_tag="BSU39880" /label="yxbC gene" downshifts complement(3747053) /Source="Nicolas_upshifts" /id="D2062" /incds=0 /nref=5 /ntot=98 /MaxReadThrough="5.86537" /MaxDrop="5.28716" /score="-7.41869067" /energy="-10.9" /TU="U3136" /idTUdmin="U3136" /TUdmin="-1188" /isTUend="FALSE" /label="downshifts" downshifts 3748011 /Source="Nicolas_upshifts" /id="D2063" /incds=0 /nref=2 /ntot=56 /MaxReadThrough="1.15059" /MaxDrop="3.74519" /score="9.93493822" /energy="-12.4" /TU="NA" /idTUdmin="U3134" /TUdmin=4026 /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3748044..3748063) /Source="Nicolas_upshift_promotors" /id="U3136" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=476 /SigmaFactorBS="acaactaaatattataatcctctgataattctgtcaaTATTT ACTtttagaaaaaaatgTTATATCTTTGTGGTGAAGTtactttttttgggagggataa t" /listShort="yxbC, yxbD, S1533" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3748062) /Source="Nicolas_upshifts" /id="U3136" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=476 /SigmaFactorBS="acaactaaatattataatcctctgataattctgtcaaTATTT ACTtttagaaaaaaatgTTATATCTTTGTGGTGAAGTtactttttttgggagggataa t" /listShort="yxbC, yxbD, S1533" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3748078..3748085) /Source="Nicolas_upshift_promotors" /id="U3136" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=476 /SigmaFactorBS="acaactaaatattataatcctctgataattctgtcaaTATTT ACTtttagaaaaaaatgTTATATCTTTGTGGTGAAGTtactttttttgggagggataa t" /listShort="yxbC, yxbD, S1533" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3748084..3748091 /Source="Nicolas_upshift_promotors" /id="U3137" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=477 /SigmaFactorBS="cttcaccacaaagatataacatttttttctaaaagtaaaTAT TGACAgaattatcagaggaTTATAATATTTAGTTGTGCGtgatagcctatttttttac a" /listShort="S1534, yxbB, aslA, yxnB, asnH, yxaM" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3748105..3748529 /Source="Nicolas_S_feature" /locus_tag="new_4096991_4097415" /HighExp="T2.0H, T5.0H, M9-stat, T3.0H, T1.30H, T1.0H, T3.30H, T2.30H, T4.0H, Pyr" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.998942" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1534" upshifts 3748105 /Source="Nicolas_upshifts" /id="U3137" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=477 /SigmaFactorBS="cttcaccacaaagatataacatttttttctaaaagtaaaTAT TGACAgaattatcagaggaTTATAATATTTAGTTGTGCGtgatagcctatttttttac a" /listShort="S1534, yxbB, aslA, yxnB, asnH, yxaM" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3748106..3748125 /Source="Nicolas_upshift_promotors" /id="U3137" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.99100899100899" /psig=1 /xcortree=477 /SigmaFactorBS="cttcaccacaaagatataacatttttttctaaaagtaaaTAT TGACAgaattatcagaggaTTATAATATTTAGTTGTGCGtgatagcctatttttttac a" /listShort="S1534, yxbB, aslA, yxnB, asnH, yxaM" /GFF_Attribute="listLong" /label="promotor_-10" misc_RNA 3748111..3748523 /gene="srlX" /locus_tag="BSU_misc_RNA_86" /product="putative small RNA or mRNA leader sequence" /experiment="publication(s) with functional evidences, PMID:20525796" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 20525796; Product type n: RNA" /label="srlX RNA" gene 3748111..3748523 /gene="srlX" /locus_tag="BSU_misc_RNA_86" /label="srlX gene" upshifts complement(3748131) /Source="Nicolas_upshifts" /id="U3138" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=719 /SigmaFactorBS="agacgaggtttcttataagcctttTTCATccttttcCCTCCT TCCTTGTAAaaaaataggctatcacgcacaactaaatattataatcctctgataattc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3748141..3748155) /Source="Nicolas_upshift_promotors" /id="U3138" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=719 /SigmaFactorBS="agacgaggtttcttataagcctttTTCATccttttcCCTCCT TCCTTGTAAaaaaataggctatcacgcacaactaaatattataatcctctgataattc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3748163..3748167) /Source="Nicolas_upshift_promotors" /id="U3138" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.999000999001" /psig="0.000999000999001" /xcortree=719 /SigmaFactorBS="agacgaggtttcttataagcctttTTCATccttttcCCTCCT TCCTTGTAAaaaaataggctatcacgcacaactaaatattataatcctctgataattc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3748495 /Source="Nicolas_upshifts" /id="D2064" /incds=0 /nref=2 /ntot=9 /MaxReadThrough="8.39077" /MaxDrop="5.02548" /score="9.93493822" /energy="-12.4" /TU="U3137" /idTUdmin="U3134" /TUdmin=4510 /isTUend="FALSE" /label="downshifts" CDS 3748530..3749264 /gene="yxbB" /locus_tag="BSU_39890" /old_locus_tag="BSU39890" /EC_number="2.1.1.-" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15941984, 20185509; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative S-adenosylmethionine-dependent methyltransferase" /protein_id="NP_391868.1" /db_xref="EnsemblGenomes-Gn:BSU39890" /db_xref="EnsemblGenomes-Tr:CAB16025" /db_xref="GOA:P46326" /db_xref="InterPro:IPR013216" /db_xref="InterPro:IPR029063" /db_xref="SubtiList:BG11352" /db_xref="UniProtKB/Swiss-Prot:P46326" /translation="MITAEECRTYKEFVDLYQSYLYPLLGARLSRMYSPKNKVIIDMG TGPGYLSIQLAKRTNAHVHAVDINPAMHEIAQEEAKKSGVSSLISFDLEDVHHLSYAD QYADFIVSYSCLHHWEDVVKGLKECYRVLAPGGKIVILDTFNPQGSHLEIMRKQIKEP EYFRFVREAFEESYSFEDIHQFVQDAGIPNYSLETFHFLPEDFIESLDELEDAPLWEQ NDQSTDHEIESVTWMLTIEKEKEGAL*" /label="yxbB CDS" gene 3748530..3749264 /gene="yxbB" /locus_tag="BSU_39890" /old_locus_tag="BSU39890" /label="yxbB gene" CDS 3749264..3749533 /gene="yxbA" /locus_tag="BSU_39900" /old_locus_tag="BSU39900" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 17083466" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391869.1" /db_xref="EnsemblGenomes-Gn:BSU39900" /db_xref="EnsemblGenomes-Tr:CAB16026" /db_xref="InterPro:IPR008792" /db_xref="SubtiList:BG11351" /db_xref="UniProtKB/Swiss-Prot:P46325" /translation="MINESTVLSKNPEMPSRKYLKSIIIEPGITLNEMASDIYNHIDG KVSIHDICSKIVNEYDVDYQTCLEDCMELFELLIDHEAIKVKQGA*" /label="yxbA CDS" gene 3749264..3749533 /gene="yxbA" /locus_tag="BSU_39900" /old_locus_tag="BSU39900" /label="yxbA gene" CDS 3749537..3750019 /gene="yxnB" /locus_tag="BSU_39910" /old_locus_tag="BSU39910" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 20185509" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391870.1" /db_xref="EnsemblGenomes-Gn:BSU39910" /db_xref="EnsemblGenomes-Tr:CAB16027" /db_xref="SubtiList:BG14166" /db_xref="UniProtKB/Swiss-Prot:O34704" /translation="MEKQKVLALPDDVHELSTHRSKSIVNYIITLLAFAKKQGLTHQD IVSWIHEQYEERGYYDEWRHINSQQPVGSFVELFIKGRRLLYDKIELFETEDKYVVNT HTWYEKEPSEAFFYFEIDPEEFSAYASILAIENAKRLGIKIDIVKETDVETAYIYKHQ *" /label="yxnB CDS" gene 3749537..3750019 /gene="yxnB" /locus_tag="BSU_39910" /old_locus_tag="BSU39910" /label="yxnB gene" CDS 3750040..3752283 /gene="asnH" /locus_tag="BSU_39920" /old_locus_tag="BSU39920" /EC_number="6.3.5.4" /function="16.13: Shape" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:10498721, 17083466, 20185509" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10498721, 17083466, 20185509; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="asparagine synthetase (glutamine-hydrolyzing)" /protein_id="NP_391871.2" /db_xref="EnsemblGenomes-Gn:BSU39920" /db_xref="EnsemblGenomes-Tr:CAB16028" /db_xref="GOA:P42113" /db_xref="InterPro:IPR001962" /db_xref="InterPro:IPR006426" /db_xref="InterPro:IPR014729" /db_xref="InterPro:IPR017932" /db_xref="InterPro:IPR029055" /db_xref="InterPro:IPR033738" /db_xref="SubtiList:BG11116" /db_xref="UniProtKB/Swiss-Prot:P42113" /translation="MCGLAGIINLAAPRSQECTFHILKGMADAISYRGPDDEQYHIDS KVGFAFRRLSILDLVNGQQPFLNEDGSIVVMVNGEIYNYKELKASLHNHMFKTTSDCE VIVHLYEEKGIGFVDDIIGMFSIAIWDKNKNKVFLVRDRFGIKPLFYTELKHELIFAS EIKSLFSHPHCPRQFNWKEALSDIWLSGEAASNHKETTSFFVNIQNLDAGHYLEINLT TNERKTASYWSLQDILLRQGYRENLHPDDLIEGYRELLADSVHRCLQSDVEVGLFLSG GIDSAAVAHFAAEKQDLHTFTVLSQSTFTNEDAKYAHWLAKDLHLPNHQVLYQLGNDE LLQPESYKHLLWICETPFCGPEQLYKFHLHKYAKAIRPNLKVMLTGQGSDEFNGGYST TLSPAENPSWEGFIESVNTMEMNRLHRLQGNIFRVWEEHFGLSPINLSYLKSNDSSQA DPWQSYVLTKYRDLQMYNCWHEDRIAAANHIENRVPFLDHRLVEWVCGIPDGLRKDLL WDKSVLRKSLTNELHTSYTHRPKVPFFYGKDVRYTHKMMFHLLKKNNYQLIEEAFSHS DASSIIQVEHIHAIMTYLEDDPEFTNFEFLLRLVNMGLLSKMTKETPSVQLDITSHLE SITIKDWHSQEGDIASRLNISANKCEGQDILALNPGVTLLRPESDSEHCIYIAEEGFI QFIVSEEDVGAWLHILCDINGKDTLHTILDRHGVSLEEVAKYIQEAIEHNIILIKQKN LPEGAYR*" /label="asnH CDS" gene 3750040..3752283 /gene="asnH" /locus_tag="BSU_39920" /old_locus_tag="BSU39920" /label="asnH gene" CDS 3752280..3753479 /gene="yxaM" /locus_tag="BSU_39930" /old_locus_tag="BSU39930" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15101989, 15849754, 16850406, 20185509; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_391872.2" /db_xref="EnsemblGenomes-Gn:BSU39930" /db_xref="EnsemblGenomes-Tr:CAB16029" /db_xref="GOA:P42112" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG11115" /db_xref="UniProtKB/Swiss-Prot:P42112" /translation="MSIFYSFSALRGLAMGIFSPIWILYLISKDYDFLQIGLMGAVLE IAKLIFEVPSGVFADRYGIKISIASSFFFSILTWAFFPFIDSAAICILAMIIWALSDS LISGSFETWMSRVAGEDRFGKEMMKNTQLLITFLIIGSIASGYLYSLNIYFPFLLVMV IYLLLFIWMSVFIKVPSVSETNHGDQNQHDSIKIIKESLKIIFNKKRVLLIVIAGFFT ATAYDTISRYWQPFLSDLGFSEKSLGYIFALGGFTALVLLTLTIRFEKKIEKNPYLAL TSLDSMGMVMTFLLSRAFRPLGIPCTAFLLAIEDIHHPIVTSYLNKFFPDSYKNTLFS LNSGVGAIGEILSGVIFGIISAAFGLSAMFVVVAVFLLIPIILYTIVPKIKDNDMKVQ IEKSQQV*" /label="yxaM CDS" gene 3752280..3753479 /gene="yxaM" /locus_tag="BSU_39930" /old_locus_tag="BSU39930" /label="yxaM gene" promotor_-10 complement(3753235..3753253) /Source="Nicolas_upshift_promotors" /id="U3139" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=266 /SigmaFactorBS="aagaatttctccaattgctcctacccctgagtttaacgagaa aAGTGTGTtcttgtatgaatcgGGGAAAAACTTATTTAAGTaacttgttacgatcgga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3753257) /Source="Nicolas_upshifts" /id="U3139" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=266 /SigmaFactorBS="aagaatttctccaattgctcctacccctgagtttaacgagaa aAGTGTGTtcttgtatgaatcgGGGAAAAACTTATTTAAGTaacttgttacgatcgga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3753268..3753274) /Source="Nicolas_upshift_promotors" /id="U3139" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=266 /SigmaFactorBS="aagaatttctccaattgctcctacccctgagtttaacgagaa aAGTGTGTtcttgtatgaatcgGGGAAAAACTTATTTAAGTaacttgttacgatcgga t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3753470 /Source="Nicolas_upshifts" /id="D2065" /incds=0 /nref=71 /ntot=174 /MaxReadThrough="3.22879" /MaxDrop="5.42242" /score="-6.94914943" /energy="-8.5" /TU="U3137" /idTUdmin="U3137" /TUdmin="-85" /isTUend="FALSE" /label="downshifts" downshifts complement(3753543) /Source="Nicolas_upshifts" /id="D2066" /incds=0 /nref=156 /ntot=227 /MaxReadThrough="3.53794" /MaxDrop="6.77896" /score="7.32872401" /energy="-16.9" /TU="U3140" /idTUdmin="U3141" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3753543..3754775) /gene="yxaL" /locus_tag="BSU_39940" /old_locus_tag="BSU39940" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12073041, 15743949, 17060472, 18165306, 22720735, 26060272; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="membrane associated protein kinase with beta-propeller domain" /protein_id="NP_391873.2" /db_xref="EnsemblGenomes-Gn:BSU39940" /db_xref="EnsemblGenomes-Tr:CAB16030" /db_xref="GOA:P42111" /db_xref="InterPro:IPR002372" /db_xref="InterPro:IPR011047" /db_xref="InterPro:IPR018391" /db_xref="SubtiList:BG11114" /db_xref="UniProtKB/Swiss-Prot:P42111" /translation="MVKSFRMKALIAGAAVAAAVSAGAVSDVPAAKVLQPTAAYAAET VFSQNNGASGFLPGRYDVQAMAPAMFNWSRESRFAGNTDGTLKWQNDIRTTPQNGAGA VIDGDGTVYLHSRDGEMKAFNPDGSVKWVTGNLGKTYTQSPVLGTNGVIYLASYDKKI YFIDKETGEILTTVPLSGGPSSETVIGSDGTLYFSTLDNYVHAIKPTSKSTWTERWKL KTNGVVSSVPVLAKNGTVYVGTYNYVFYAINSGTGQVKWSRTTSNAFKGYPVIDKDGN IYAGNQDGQLYAYTSTGSLKWTFPLNGFSSSSPAIDHNGNIYIGSGSGELFSISKNGD MNWSFYTDGPVRTAPLIDAKGTVYFGSDDMKVYAADANGNELWSYQTDSNVVSSPQLA EDGTLYIGSYTKLMAFGK*" /label="yxaL CDS" gene complement(3753543..3754775) /gene="yxaL" /locus_tag="BSU_39940" /old_locus_tag="BSU39940" /label="yxaL gene" promotor_-10 complement(3754807..3754826) /Source="Nicolas_upshift_promotors" /id="U3140" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.417582417582418" /psig="0.999000999001" /xcortree=1611 /SigmaFactorBS="atagttttctagtttgtgatgtttttgtgaaataGATTTAta aaatggatgaaTATGTTATGATGGTCACAAAttagaagttacatataatgggggtctc a" /listShort="yxaL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3754819) /Source="Nicolas_upshifts" /id="U3140" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.417582417582418" /psig="0.999000999001" /xcortree=1611 /SigmaFactorBS="atagttttctagtttgtgatgtttttgtgaaataGATTTAta aaatggatgaaTATGTTATGATGGTCACAAAttagaagttacatataatgggggtctc a" /listShort="yxaL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3754840..3754845) /Source="Nicolas_upshift_promotors" /id="U3140" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.417582417582418" /psig="0.999000999001" /xcortree=1611 /SigmaFactorBS="atagttttctagtttgtgatgtttttgtgaaataGATTTAta aaatggatgaaTATGTTATGATGGTCACAAAttagaagttacatataatgggggtctc a" /listShort="yxaL" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3754876..3755301) /gene="yxaJ" /locus_tag="BSU_39950" /old_locus_tag="BSU39950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15743949, 15849754, 16850406, 27902860; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein of unknown function" /protein_id="NP_391875.2" /db_xref="EnsemblGenomes-Gn:BSU39950" /db_xref="EnsemblGenomes-Tr:CAB16032" /db_xref="GOA:P42109" /db_xref="InterPro:IPR020204" /db_xref="SubtiList:BG11112" /db_xref="UniProtKB/Swiss-Prot:P42109" /translation="MSKKNSVAIMTTISAFLFCAVIVAASLSPLAGTGAAANQFNSAG MWSAVGMILVLYFIPFLVYMLGVDAMRYVMAVLCGFGLLIHLSSAGFILMFSFFSDHL LSEVIFVLGVSLAAAAVNVIWFVAAFRSGAEKTSVNTLT*" /label="yxaJ CDS" gene complement(3754876..3755301) /gene="yxaJ" /locus_tag="BSU_39950" /old_locus_tag="BSU39950" /label="yxaJ gene" promotor_-10 complement(3755329..3755348) /Source="Nicolas_upshift_promotors" /id="U3141" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.452547452547453" /psig=1 /xcortree=2293 /SigmaFactorBS="catttgtgtatgtattctggaattttttaaaaatatAATGAA TataacattcaacTTACTTATAATAAAAAAGGTtaatatttctattaaaggaggagtt t" /listShort="yxaJ, yxaL" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3755343) /Source="Nicolas_upshifts" /id="U3141" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.452547452547453" /psig=1 /xcortree=2293 /SigmaFactorBS="catttgtgtatgtattctggaattttttaaaaatatAATGAA TataacattcaacTTACTTATAATAAAAAAGGTtaatatttctattaaaggaggagtt t" /listShort="yxaJ, yxaL" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3755361..3755367) /Source="Nicolas_upshift_promotors" /id="U3141" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.452547452547453" /psig=1 /xcortree=2293 /SigmaFactorBS="catttgtgtatgtattctggaattttttaaaaatatAATGAA TataacattcaacTTACTTATAATAAAAAAGGTtaatatttctattaaaggaggagtt t" /listShort="yxaJ, yxaL" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3755493..3755500 /Source="Nicolas_upshift_promotors" /id="U3142" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.526473526473527" /psig="0.995004995004995" /xcortree=2320 /SigmaFactorBS="aagactcatttttctgtaatatcaggattttatcaccatacc aTATTGCATgtacatgtttttcaAAGTATACTATTCCAGATTAattcagaggagagag a" /listShort="yxaI, S1535" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3755510 /Source="Nicolas_upshifts" /id="U3142" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.526473526473527" /psig="0.995004995004995" /xcortree=2320 /SigmaFactorBS="aagactcatttttctgtaatatcaggattttatcaccatacc aTATTGCATgtacatgtttttcaAAGTATACTATTCCAGATTAattcagaggagagag a" /listShort="yxaI, S1535" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3755515..3755534 /Source="Nicolas_upshift_promotors" /id="U3142" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.526473526473527" /psig="0.995004995004995" /xcortree=2320 /SigmaFactorBS="aagactcatttttctgtaatatcaggattttatcaccatacc aTATTGCATgtacatgtttttcaAAGTATACTATTCCAGATTAattcagaggagagag a" /listShort="yxaI, S1535" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3755558..3756013 /gene="yxaI" /locus_tag="BSU_39960" /old_locus_tag="BSU39960" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein of unknown function" /protein_id="NP_391876.1" /db_xref="EnsemblGenomes-Gn:BSU39960" /db_xref="EnsemblGenomes-Tr:CAB16033" /db_xref="GOA:P42108" /db_xref="InterPro:IPR010432" /db_xref="SubtiList:BG11111" /db_xref="UniProtKB/Swiss-Prot:P42108" /translation="MEKPAGFWIRFLAYFIDGIIVSVPSYIILFIINSVFVAGAVATN PYMTEEEYLVKYMTLAFLPTMLIMIVISVLYYGLLTASKMQGTLGKKILGLKVVNEQG ERVSVGQGIGRYFAYILSGIIFYIGFIMIAFGEKKGLHDIICKTRVVYK*" /label="yxaI CDS" gene 3755558..3756013 /gene="yxaI" /locus_tag="BSU_39960" /old_locus_tag="BSU39960" /label="yxaI gene" downshifts 3755951 /Source="Nicolas_upshifts" /id="D2067" /incds=1 /nref=58 /ntot=234 /MaxReadThrough="3.24719" /MaxDrop="5.4441" /score="18.1083522" /energy="-13.4" /TU="U3142" /idTUdmin="U3142" /TUdmin="-637" /isTUend="FALSE" /label="downshifts" S_feature 3756014..3756627 /Source="Nicolas_S_feature" /locus_tag="new_4104900_4105513" /HighExp="LPh, HPh, MG 60, BMM, MG t5, G180, MG 45, G150, MG-0.2, MG 10" /AntisenseName="yxaH" /AntisenseCor="0.37646026982403002" /AntisenseRegPval="-9.8000000000000007" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S1535" CDS complement(3756043..3757251) /gene="yxaH" /locus_tag="BSU_39970" /old_locus_tag="BSU39970" /experiment="publication(s) with functional evidences, PMID:15317768, 15849754, 16850406, 21737930" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15317768, 15849754, 16850406, 21737930; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="integral inner membrane protein involved in response to flavonoids" /protein_id="NP_391877.2" /db_xref="EnsemblGenomes-Gn:BSU39970" /db_xref="EnsemblGenomes-Tr:CAB16034" /db_xref="GOA:P42107" /db_xref="InterPro:IPR007349" /db_xref="SubtiList:BG11110" /db_xref="UniProtKB/Swiss-Prot:P42107" /translation="MSSLQPTLTNERIGVLDVLRGMAIFGILFVNLAHFSYPDMYLSM LGKENFFMDKWSEADFAAADILKFFIQTKCILLFSFLFGFGMVVMMERAENKGKRFVP LYVRRLMALLLFGTIHAFLIWDGDILTEYALLGFVLLLFRKAKPKTLLIWAVSLYLLF SIPFMLTSFDQSNGQEWVQAVTQQAKQAIHVYGSGSLKDIAEQRIHDRLVYMSSNGML TYNPLNYFFASIPYFSMFLLGAAAAKSRYLHEPEKHRKGLKRLWMAGLVIGIGAQVLY SVTDKEICLLIGAPFLMFFYVTTVVYLYHKTRVRTVLQSFSAVGRMAFTNYLMQSIVC TWIFYHYGLGLYGKVYPAAGVLITIAVCAVQMVFSHLWLRVFRMGPFEWLWRSATYLS WQPIAKKTKV*" /label="yxaH CDS" gene complement(3756043..3757251) /gene="yxaH" /locus_tag="BSU_39970" /old_locus_tag="BSU39970" /label="yxaH gene" downshifts complement(3756070) /Source="Nicolas_upshifts" /id="D2068" /incds=0 /nref=14 /ntot=66 /MaxReadThrough="0.30987" /MaxDrop="3.782" /score="34.1593124" /energy="-16.2" /TU="NA" /idTUdmin="U3143" /TUdmin=286 /isTUend="FALSE" /label="downshifts" S_feature complement(3757252..3757358) /Source="Nicolas_S_feature" /locus_tag="new_4106138_4106244_c" /HighExp="T-5.40H, T-4.40H, SMMPr, T-2.40H, T-3.40H, T-1.40H, Sw, T0.0H, Pyr, T-0.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S1536" CDS complement(3757359..3758372) /gene="qdoI" /locus_tag="BSU_39980" /old_locus_tag="BSU39980" /EC_number="1.13.11.24" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:14697267, 15317768, 15628860, 17483215, 14741339, 15039076, 20460727, 21737930" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14697267, 15317768, 15628860, 17483215, 14741339, 15039076, 20460727, 21737930; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="quercetin dioxygenase" /protein_id="NP_391878.2" /db_xref="EnsemblGenomes-Gn:BSU39980" /db_xref="EnsemblGenomes-Tr:CAB16035" /db_xref="GOA:P42106" /db_xref="InterPro:IPR011051" /db_xref="InterPro:IPR013096" /db_xref="InterPro:IPR014710" /db_xref="PDB:1Y3T" /db_xref="PDB:2H0V" /db_xref="SubtiList:BG11109" /db_xref="UniProtKB/Swiss-Prot:P42106" /translation="MKTLCTHSLPKEKMPYLLRSGEGERYLFGRQVATVMANGRSTGD LFEIVLLSGGKGDAFPLHVHKDTHEGILVLDGKLELTLDGERYLLISGDYANIPAGTP HSYRMQSHRTRLVSYTMKGNVAHLYSVIGNPYDHAEHPPYASEEVSNERFAEAAAVAD IVFLDEAKPACSAKLAELTELPDGAVPYVLESGEGDRLLTGDQLHRIVAAQKNTDGQF IVVSSEGPKGDRIVDHYHEYHTETFYCLEGQMTMWTDGQEIQLNPGDFLHVPANTVHS YRLDSHYTKMVGVLVPGLFEPFFRTLGDPYEGHIFPCEPQALRFDRILQNIEALDLKV MKP*" /label="qdoI CDS" gene complement(3757359..3758372) /gene="qdoI" /locus_tag="BSU_39980" /old_locus_tag="BSU39980" /label="qdoI gene" S_feature complement(3758373..3758446) /Source="Nicolas_S_feature" /locus_tag="new_4107259_4107332_c" /HighExp="T-3.40H, T-5.40H, T-1.40H, T-2.40H, T-4.40H, T-0.40H, T0.0H, Pyr, SMMPr, GM-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.995" /TUlongSig="NA" /TUlongPSig="NA" /label="S1537" promotor_-10 complement(3758431..3758450) /Source="Nicolas_upshift_promotors" /id="U3143" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.622377622377622" /psig="0.995004995004995" /xcortree=2866 /SigmaFactorBS="ttgccgaacaaataccagtgctggtgagaaaaaaagGGTAGC ATtttgttatccttTCTCCTACAATTATATAGAAcggtctagacaaatgaatgataat a" /listShort="S1537, qodI, S1536, yxaH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3758446) /Source="Nicolas_upshifts" /id="U3143" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.622377622377622" /psig="0.995004995004995" /xcortree=2866 /SigmaFactorBS="ttgccgaacaaataccagtgctggtgagaaaaaaagGGTAGC ATtttgttatccttTCTCCTACAATTATATAGAAcggtctagacaaatgaatgataat a" /listShort="S1537, qodI, S1536, yxaH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3758463..3758470) /Source="Nicolas_upshift_promotors" /id="U3143" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.622377622377622" /psig="0.995004995004995" /xcortree=2866 /SigmaFactorBS="ttgccgaacaaataccagtgctggtgagaaaaaaagGGTAGC ATtttgttatccttTCTCCTACAATTATATAGAAcggtctagacaaatgaatgataat a" /listShort="S1537, qodI, S1536, yxaH" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3758466..3759041) /gene="qdoR" /locus_tag="BSU_39990" /old_locus_tag="BSU39990" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:17483215, 21737930" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17483215, 21737930; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator of qdoI" /protein_id="NP_391879.2" /db_xref="EnsemblGenomes-Gn:BSU39990" /db_xref="EnsemblGenomes-Tr:CAB16036" /db_xref="GOA:P42105" /db_xref="InterPro:IPR001647" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR036271" /db_xref="PDB:1SGM" /db_xref="SubtiList:BG11108" /db_xref="UniProtKB/Swiss-Prot:P42105" /translation="MTSRGDSREKILHTASRLFQLQGYHATGLNQIVKESGAPKGSLY HFFPNGKEELAIEAVTYTGKIVEHLIQQSMDESSDPVEAIQLFIKKTASQFDNTESIK GIPVGLLASETALISEPLRTVCMKVFKSWEAVFARKLMENGFAEEEANQLGTLINSMI EGGIMLSLTNKDKTPLLLIAEQIPVLVRKKG*" /label="qdoR CDS" gene complement(3758466..3759041) /gene="qdoR" /locus_tag="BSU_39990" /old_locus_tag="BSU39990" /label="qdoR gene" downshifts complement(3758490) /Source="Nicolas_upshifts" /id="D2069" /incds=0 /nref=1 /ntot=19 /MaxReadThrough="1.66581" /MaxDrop="2.62803" /score="-2.51956315" /energy="-8.8" /TU="NA" /idTUdmin="U3144" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3759070..3759089) /Source="Nicolas_upshift_promotors" /id="U3144" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.85914085914086" /psig="0.999000999001" /xcortree=2479 /SigmaFactorBS="tgtacattaccccatccggaagggtcttaccccTTTTGACAa tcacagggttcttTTTTATATTATATAAGTCGCtctaccatacctaggagggaatgtt t" /listShort="yxaF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3759084) /Source="Nicolas_upshifts" /id="U3144" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.85914085914086" /psig="0.999000999001" /xcortree=2479 /SigmaFactorBS="tgtacattaccccatccggaagggtcttaccccTTTTGACAa tcacagggttcttTTTTATATTATATAAGTCGCtctaccatacctaggagggaatgtt t" /listShort="yxaF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3759104..3759111) /Source="Nicolas_upshift_promotors" /id="U3144" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.85914085914086" /psig="0.999000999001" /xcortree=2479 /SigmaFactorBS="tgtacattaccccatccggaagggtcttaccccTTTTGACAa tcacagggttcttTTTTATATTATATAAGTCGCtctaccatacctaggagggaatgtt t" /listShort="yxaF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3759112..3759118 /Source="Nicolas_upshift_promotors" /id="U3145" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=252 /SigmaFactorBS="taatataaaaaagaaccctgtgattgtcaaaaGGGGTAAgac ccttccggatgGGGTAATGTACAAAAACAGcgtctaggagggatctctcaatgacaat c" /listShort="yxnA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3759133..3759151 /Source="Nicolas_upshift_promotors" /id="U3145" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=252 /SigmaFactorBS="taatataaaaaagaaccctgtgattgtcaaaaGGGGTAAgac ccttccggatgGGGTAATGTACAAAAACAGcgtctaggagggatctctcaatgacaat c" /listShort="yxnA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3759140 /Source="Nicolas_upshifts" /id="U3145" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=252 /SigmaFactorBS="taatataaaaaagaaccctgtgattgtcaaaaGGGGTAAgac ccttccggatgGGGTAATGTACAAAAACAGcgtctaggagggatctctcaatgacaat c" /listShort="yxnA" /GFF_Attribute="listLong" /label="upshifts" CDS 3759172..3760242 /gene="yxnA" /locus_tag="BSU_40000" /old_locus_tag="BSU40000" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391880.2" /db_xref="EnsemblGenomes-Gn:BSU40000" /db_xref="EnsemblGenomes-Tr:CAB16037" /db_xref="GOA:O32291" /db_xref="InterPro:IPR002347" /db_xref="InterPro:IPR020904" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG14165" /db_xref="UniProtKB/Swiss-Prot:O32291" /translation="MTIDHSVTNTEQLEQQNPAIKTKLKLKKLKDQVIVITGASSGIG LVTARMAAEKGAKVVAAARNEEALKELTDELKEKGHDAIWVKADVGKEEDVNRIAETA ISTFGRFDTWVNNAAVSTFGHAMDVTVEDMKRMFDTNFWGPVYGTRAAVKHYTGRGVP GALINVGSLFGDRGTVIQSTYASAKFALHGWTESIRMELEKEQAPVSVTLIHPGRIDT PYNEHAHSYLDKQPAHYRSMIYPPEAVAEAILFAAEHPKRDMYIGSQAKAIAMLGALF PRLTDRLMEKIMYHSQHAERPSNPREESALYDAGCGMHDRGTNKGWMRSRSYYTKATK RPIVSAAVVAGLVAWAAAKRCR*" /label="yxnA CDS" gene 3759172..3760242 /gene="yxnA" /locus_tag="BSU_40000" /old_locus_tag="BSU40000" /label="yxnA gene" downshifts 3760240 /Source="Nicolas_upshifts" /id="D2070" /incds=0 /nref=7 /ntot=44 /MaxReadThrough="2.68466" /MaxDrop="3.96227" /score="-3.48213422" /energy="-11.2" /TU="NA" /idTUdmin="U3145" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3760299..3760730) /gene="yxaD" /locus_tag="BSU_40010" /old_locus_tag="BSU40010" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MarR family)" /protein_id="NP_391881.1" /db_xref="EnsemblGenomes-Gn:BSU40010" /db_xref="EnsemblGenomes-Tr:CAB16038" /db_xref="GOA:P42103" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG11106" /db_xref="UniProtKB/Swiss-Prot:P42103" /translation="MQNQNPVELIEYELTTFIRRAVYLDQSEKRTGNLERSSYLLLRQ LDEFGPARVKELAESFKLDISTLSRQAAALEAKELIYRFSDPSDGRVSLFTITKLGKQ LLKADQQKRLERYEQMLKEWSTQEKEMFGELLQRMNKAFID*" /label="yxaD CDS" gene complement(3760299..3760730) /gene="yxaD" /locus_tag="BSU_40010" /old_locus_tag="BSU40010" /label="yxaD gene" promotor_-35 3760760..3760767 /Source="Nicolas_upshift_promotors" /id="U3146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2436 /SigmaFactorBS="atcgctctcgctccctattccaatctccggCATTGACAacat catatatacTTGTATAATACAAATGTACAttaactgaataaatacaagtcgttatatg a" /listShort="S1538, yxzK, yxaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3760781..3760800 /Source="Nicolas_upshift_promotors" /id="U3146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2436 /SigmaFactorBS="atcgctctcgctccctattccaatctccggCATTGACAacat catatatacTTGTATAATACAAATGTACAttaactgaataaatacaagtcgttatatg a" /listShort="S1538, yxzK, yxaC" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3760790..3760956 /Source="Nicolas_S_feature" /locus_tag="new_4109676_4109842" /HighExp="LBGstat, Cold, Heat, Salt, Etha, H2O2, G180, LBGtran, GM 150, MG 15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1538" upshifts 3760790 /Source="Nicolas_upshifts" /id="U3146" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.96903096903097" /psig=1 /xcortree=2436 /SigmaFactorBS="atcgctctcgctccctattccaatctccggCATTGACAacat catatatacTTGTATAATACAAATGTACAttaactgaataaatacaagtcgttatatg a" /listShort="S1538, yxzK, yxaC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3760842..3760861) /Source="Nicolas_upshift_promotors" /id="U3147" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.85014985014985" /psig="0.999000999001" /xcortree=2442 /SigmaFactorBS="cctttctggtgcttgcttctaggatggttctgaggaatcGCT TTACTttctttttatatgaTTGTACTATACAAGTATAATaattgatttagtcatataa c" /listShort="yxaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3760862) /Source="Nicolas_upshifts" /id="U3147" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.85014985014985" /psig="0.999000999001" /xcortree=2442 /SigmaFactorBS="cctttctggtgcttgcttctaggatggttctgaggaatcGCT TTACTttctttttatatgaTTGTACTATACAAGTATAATaattgatttagtcatataa c" /listShort="yxaD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3760876..3760883) /Source="Nicolas_upshift_promotors" /id="U3147" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.85014985014985" /psig="0.999000999001" /xcortree=2442 /SigmaFactorBS="cctttctggtgcttgcttctaggatggttctgaggaatcGCT TTACTttctttttatatgaTTGTACTATACAAGTATAATaattgatttagtcatataa c" /listShort="yxaD" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3760957..3761361 /gene="yxzK" /locus_tag="BSU_40021" /old_locus_tag="BSU40021" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein involved in export murein hydrolases" /protein_id="YP_003097798.1" /db_xref="EnsemblGenomes-Gn:BSU40021" /db_xref="EnsemblGenomes-Tr:CAX52713" /db_xref="GOA:C0H3T7" /db_xref="InterPro:IPR005538" /db_xref="InterPro:IPR036640" /db_xref="UniProtKB/Swiss-Prot:C0H3T7" /translation="MKVIRIILQVLILYVFFMIGEAIQHLFHLPVSGSIVGLVLLLIC LGLRIVPVSIIEDGAGFLLSFLPLLFIPAMTGVINYPSLISFNGLMLLITVVLSTIVT IIAAGFASQLLEKKAKKREEKEKCSKHVSRSL*" /label="yxzK CDS" gene 3760957..3761361 /gene="yxzK" /locus_tag="BSU_40021" /old_locus_tag="BSU40021" /label="yxzK gene" S_feature complement(3760978..3762030) /Source="Nicolas_S_feature" /locus_tag="new_4109864_4110916_c" /HighExp="Etha, C30, H2O2, Salt, Paraq, GM 120, Diami, Oxctl, G180, Sw" /AntisenseName="yxaC" /AntisenseCor="0.145103505386703" /AntisenseRegPval="-1.8" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig="0.987" /TUlongSig="NA" /TUlongPSig="NA" /label="S1539" CDS 3761331..3762023 /gene="yxaC" /locus_tag="BSU_40022" /old_locus_tag="BSU40022" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15126464, 15849754, 16850406, 17452642, 26060272; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative murein hydrolase export regulator" /protein_id="NP_391882.3" /db_xref="EnsemblGenomes-Gn:BSU40022" /db_xref="EnsemblGenomes-Tr:CAB16039" /db_xref="GOA:P42102" /db_xref="InterPro:IPR007300" /db_xref="SubtiList:BG11105" /db_xref="UniProtKB/Swiss-Prot:P42102" /translation="MQQACIAIIIILLTVAAYLAMVKLYKRFPLPFLIPVLTTTILIV AALMMFHVSYEGYMIGGKWINSLLGPAVVALAYPLYKQWHIIVKHCVPILGGVLVGLC MGMISGLIFAEAFGIDHDLLLSILPKSITTPVAIQIAAGLGGVPSMTVVFVMIAGFSG VILGPLFLKWLRIRSSLGQGIALGSASHALGTSKALEYGELAVSMSSVSMTLCAVLGS FFGPLVVWLFHI*" /label="yxaC CDS" gene 3761331..3762023 /gene="yxaC" /locus_tag="BSU_40022" /old_locus_tag="BSU40022" /label="yxaC gene" CDS complement(3762063..3763094) /gene="yxaB" /locus_tag="BSU_40030" /old_locus_tag="BSU40030" /EC_number="2.-.-.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9298659, 18326573; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative exopolysaccharide pyruvyl transferase (biofilm formation)" /protein_id="NP_391883.3" /db_xref="EnsemblGenomes-Gn:BSU40030" /db_xref="EnsemblGenomes-Tr:CAB16040" /db_xref="GOA:P42101" /db_xref="InterPro:IPR007345" /db_xref="SubtiList:BG11104" /db_xref="UniProtKB/Swiss-Prot:P42101" /translation="MTVQEIKGKKLVKGIAPNVEPEALLNDKRKVFLFGSPSYTNIGD QAIAYAEEKFIKNHFPYYEYIEIMDYATDEGIELVKEIIREDDIVCFTGGGNLGNLYL DIEEDRRKVFSAFKDYKSISLPQSVYFEDTEEGQKEKKKTQDAYHQNTNLTIAARETQ TLDVVKETFNSNVIFTPDMVLSLDIVPRELERDGVLFILRADKEKVTDEDFISQMKQW AEKTTYTERTDTVLDTVDTIDYADREKHFMEMLDRIGSSKLVITDRLHAMIFSIITKT PCLVFGNSYGKAKHSYRDWLESLNFIEYTDKNDVEELERMIDRLLQAEPNDVDLSKDF QPLIDFFAS*" /label="yxaB CDS" gene complement(3762063..3763094) /gene="yxaB" /locus_tag="BSU_40030" /old_locus_tag="BSU40030" /label="yxaB gene" downshifts complement(3762075) /Source="Nicolas_upshifts" /id="D2071" /incds=0 /nref=5 /ntot=94 /MaxReadThrough="6.52386" /MaxDrop="4.6522" /score="17.8326496" /energy="-15.3" /TU="U3149" /idTUdmin="U3150" /TUdmin=220 /isTUend="FALSE" /label="downshifts" promotor_-35 3763061..3763064 /Source="Nicolas_upshift_promotors" /id="U3148" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.618381618381618" /psig="0.996003996003996" /xcortree=1822 /SigmaFactorBS="atttaacagagcttccggctccacatttggcgcaatgccttt taCTAGttttttgcctttgattTCTTGTACAGTCATATCTGCgtcctccttctgggat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3763077 /Source="Nicolas_upshifts" /id="U3148" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.618381618381618" /psig="0.996003996003996" /xcortree=1822 /SigmaFactorBS="atttaacagagcttccggctccacatttggcgcaatgccttt taCTAGttttttgcctttgattTCTTGTACAGTCATATCTGCgtcctccttctgggat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3763081..3763100 /Source="Nicolas_upshift_promotors" /id="U3148" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.618381618381618" /psig="0.996003996003996" /xcortree=1822 /SigmaFactorBS="atttaacagagcttccggctccacatttggcgcaatgccttt taCTAGttttttgcctttgattTCTTGTACAGTCATATCTGCgtcctccttctgggat g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(3763131..3763149) /Source="Nicolas_upshift_promotors" /id="U3149" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=258 /SigmaFactorBS="cgaaaacgatgtttctgatatagccgatgcacatgccaaTGC ATAGccatccttctttttGGGTAGAGACAGTTAACACacaatgaggaattcatcccag a" /listShort="yxaB, S1539" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3763149) /Source="Nicolas_upshifts" /id="U3149" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=258 /SigmaFactorBS="cgaaaacgatgtttctgatatagccgatgcacatgccaaTGC ATAGccatccttctttttGGGTAGAGACAGTTAACACacaatgaggaattcatcccag a" /listShort="yxaB, S1539" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3763164..3763170) /Source="Nicolas_upshift_promotors" /id="U3149" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.987012987012987" /psig="0.987012987012987" /xcortree=258 /SigmaFactorBS="cgaaaacgatgtttctgatatagccgatgcacatgccaaTGC ATAGccatccttctttttGGGTAGAGACAGTTAACACacaatgaggaattcatcccag a" /listShort="yxaB, S1539" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3763187..3764335) /gene="glxK" /locus_tag="BSU_40040" /old_locus_tag="BSU40040" /EC_number="2.7.1.31" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15771780, 18326573; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-glycerate kinase" /protein_id="NP_391884.2" /db_xref="EnsemblGenomes-Gn:BSU40040" /db_xref="EnsemblGenomes-Tr:CAB16041" /db_xref="GOA:P42100" /db_xref="InterPro:IPR004381" /db_xref="InterPro:IPR018193" /db_xref="InterPro:IPR036129" /db_xref="SubtiList:BG11103" /db_xref="UniProtKB/Swiss-Prot:P42100" /translation="MKIIIAPDSFKESLSALEAAEAIERGFKSVFPGADYRKLPVADG GEGTVQSLVDATNGRIIEQVVTGPLGEPVRAFFGMMGDGRTAVIEMAAASGLHLVPVD KRNPLITTTRGTGELIGAALDAGAERLIIGIGGSATNDGGAGMIQALGGRLLDNSGSE IGPGGGALSQLASIDVSGLDSRLRNVKLEVACDVDNPLTGPKGATAVFGPQKGATADM LDVLDQNVSHFADMAEKALGSTFRDTEGAGAAGGLGWSLLTYLQADLKRGIDIVLEAV DFESIVQDADLVITGEGRIDSQTVHGKTPIGVAKAAKSYDVPVIGIAGSISRDSNAVY QHGIDALFSIVPGAVPLEDAFEHAAEYMERTARDIAASIKLAKTMFLI*" /label="glxK CDS" gene complement(3763187..3764335) /gene="glxK" /locus_tag="BSU_40040" /old_locus_tag="BSU40040" /label="glxK gene" promotor_-10 complement(3764374..3764393) /Source="Nicolas_upshift_promotors" /id="U3150" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=3162 /SigmaFactorBS="aatttttatttaaatttttaccatattgcatggtATGTATTT ccagatcaatTATGGTACATTGGAGATCAAtaggttaagtgaatcatgttttgaaaga g" /listShort="glxK, yxaB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3764385) /Source="Nicolas_upshifts" /id="U3150" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=3162 /SigmaFactorBS="aatttttatttaaatttttaccatattgcatggtATGTATTT ccagatcaatTATGGTACATTGGAGATCAAtaggttaagtgaatcatgttttgaaaga g" /listShort="glxK, yxaB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3764404..3764411) /Source="Nicolas_upshift_promotors" /id="U3150" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.982017982017982" /psig=1 /xcortree=3162 /SigmaFactorBS="aatttttatttaaatttttaccatattgcatggtATGTATTT ccagatcaatTATGGTACATTGGAGATCAAtaggttaagtgaatcatgttttgaaaga g" /listShort="glxK, yxaB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3764457..3764464 /Source="Nicolas_upshift_promotors" /id="U3151" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=1787 /SigmaFactorBS="gtaaaaatttaaataaaaattagaaatgaaagTGTTTGCAta aaagaaatattCACGTTATCATACTTGTATAcaagtatactccttgagtgaggaaggt g" /listShort="gntR, gntK, gntP, gntZ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3764478..3764497 /Source="Nicolas_upshift_promotors" /id="U3151" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=1787 /SigmaFactorBS="gtaaaaatttaaataaaaattagaaatgaaagTGTTTGCAta aaagaaatattCACGTTATCATACTTGTATAcaagtatactccttgagtgaggaaggt g" /listShort="gntR, gntK, gntP, gntZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3764485 /Source="Nicolas_upshifts" /id="U3151" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.877122877122877" /psig=1 /xcortree=1787 /SigmaFactorBS="gtaaaaatttaaataaaaattagaaatgaaagTGTTTGCAta aaagaaatattCACGTTATCATACTTGTATAcaagtatactccttgagtgaggaaggt g" /listShort="gntR, gntK, gntP, gntZ" /GFF_Attribute="listLong" /label="upshifts" CDS 3764531..3765262 /gene="gntR" /locus_tag="BSU_40050" /old_locus_tag="BSU40050" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:7476858, 7642511, 8655507, 9106211, 26151451" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7476858, 7642511, 8655507, 9106211, 26151451; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (GntR-gluconate)" /protein_id="NP_391885.1" /db_xref="EnsemblGenomes-Gn:BSU40050" /db_xref="EnsemblGenomes-Tr:CAB16042" /db_xref="GOA:P10585" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR008920" /db_xref="InterPro:IPR011711" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10648" /db_xref="UniProtKB/Swiss-Prot:P10585" /translation="MLDSKDLLYPAKWLSKASTGVRVAYELRMRIVSGLIESGTILSE NTIAAEFSVSRSPVREALKILASEKIIRLERMGAVVIGLTEKKIAEIYDVRLLLETFV FERLVKIDIEPLVKDLSKILEMMKVSIKYEDADEFSFQDVLFHETIIRAIDHSYIQMI WNNLKPVMESFILLSMRVRLKEKYEDFTRILDNHELYIQAIKTKDRALMIQSLHQNFD DVQDKVEDLWLSQQMLAKGAEYNND*" /label="gntR CDS" gene 3764531..3765262 /gene="gntR" /locus_tag="BSU_40050" /old_locus_tag="BSU40050" /label="gntR gene" CDS 3765255..3766796 /gene="gntK" /locus_tag="BSU_40060" /old_locus_tag="BSU40060" /EC_number="2.7.1.12" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:1659648, 2537826, 3020045, 11468405" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1659648, 2537826, 3020045, 11468405; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="D-gluconate kinase" /protein_id="NP_391886.1" /db_xref="EnsemblGenomes-Gn:BSU40060" /db_xref="EnsemblGenomes-Tr:CAB16043" /db_xref="GOA:P12011" /db_xref="InterPro:IPR000577" /db_xref="InterPro:IPR006002" /db_xref="InterPro:IPR018483" /db_xref="InterPro:IPR018484" /db_xref="InterPro:IPR018485" /db_xref="SubtiList:BG10649" /db_xref="UniProtKB/Swiss-Prot:P12011" /translation="MTSYMLGIDIGTTSTKAVLFSENGDVVQKESIGYPLYTPDISTA EQNPEEIFQAVIHTTARITKQHPEKRISFISFSSAMHSVIAIDENDKPLTPCITWADN RSEGWAHKIKEELNGHEVYKRTGTPIHPMAPLSKIAWITNERKEIASKAKKYIGIKEY IFKQLFNEYVIDYSLASATGMMNLKGLDWDEEALRIAGITPDHLSKLVPTTEIFQHCS PEIAIQMGIDPETPFVIGASDGVLSNLGVNAIKKGEIAVTIGTSGAIRTIIDKPQTDE KGRIFCYALTDKHWVIGGPVNNGGIVLRWIRDEFASSEIETATRLGIDPYDVLTKIAQ RVRPGSDGLLFHPYLAGERAPLWNPDVRGSFFGLTMSHKKEHMIRAALEGVIYNLYTV FLALTECMDGPVTRIQATGGFARSEVWRQMMSDIFESEVVVPESYESSCLGACILGLY ATGKIDSFDAVSDMIGSTYRHTPIEDSAKEYRTLMPIFINLSRLLENQYTQIADYQRG LITHK*" /label="gntK CDS" gene 3765255..3766796 /gene="gntK" /locus_tag="BSU_40060" /old_locus_tag="BSU40060" /label="gntK gene" CDS 3766825..3768171 /gene="gntP" /locus_tag="BSU_40070" /old_locus_tag="BSU40070" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:3020045, 15849754, 1659648, 16850406" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 3020045, 15849754, 1659648, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="gluconate/proton permease" /protein_id="NP_391887.1" /db_xref="EnsemblGenomes-Gn:BSU40070" /db_xref="EnsemblGenomes-Tr:CAB16044" /db_xref="GOA:P12012" /db_xref="InterPro:IPR003474" /db_xref="SubtiList:BG10650" /db_xref="UniProtKB/Swiss-Prot:P12012" /translation="MPLIIVALGILALLFLIMGLKLNTFISLLVVSFGVALALGMPFD KVVSSIEAGIGGTLGHIALIFGLGAMLGKLIADSGGAQRIAMTLVNKFGEKNIQWAVV IASFIIGIALFFEVGLVLLIPIVFAISRELKISILFLGIPMVAALSVTHGFLPPHPGP TAIAGEYGANIGEVLLYGFIVAVPTVLIAGPLFTKFAKKIVPASFAKNGNIASLGTQK TFNLEETPGFGISVFTAMLPIIIMSVATIIDLLQETIGFADNGVLAFIRLIGNASTAM IISLLVAVYTMGIKRNIPVKTVMDSCSTAISQIGMMLLIIGGGGAFKQVLINGGVGDY VADLFKGTALSPIILAWLIAAILRISLGSATVAALSTTGLVIPLLGHSDVNLALVVLA TGAGSVIASHVNDAGFWMFKEYFGLSMKETFATWTLLETIISVAGLGFILLLSLVV*" /label="gntP CDS" gene 3766825..3768171 /gene="gntP" /locus_tag="BSU_40070" /old_locus_tag="BSU40070" /label="gntP gene" promotor_-35 3767624..3767628 /Source="Nicolas_upshift_promotors" /id="U3152" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.801198801198801" /psig="0.998001998001998" /xcortree=2695 /SigmaFactorBS="tttgcagataacggagttttagcttttatcaGATTGattgga aacgcatcgACTGCTATGATTATTTCGTTattggtcgcagtctatacaatgggcatca a" /listShort="gntZ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3767644..3767663 /Source="Nicolas_upshift_promotors" /id="U3152" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.801198801198801" /psig="0.998001998001998" /xcortree=2695 /SigmaFactorBS="tttgcagataacggagttttagcttttatcaGATTGattgga aacgcatcgACTGCTATGATTATTTCGTTattggtcgcagtctatacaatgggcatca a" /listShort="gntZ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3767653 /Source="Nicolas_upshifts" /id="U3152" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.801198801198801" /psig="0.998001998001998" /xcortree=2695 /SigmaFactorBS="tttgcagataacggagttttagcttttatcaGATTGattgga aacgcatcgACTGCTATGATTATTTCGTTattggtcgcagtctatacaatgggcatca a" /listShort="gntZ" /GFF_Attribute="listLong" /label="upshifts" CDS 3768194..3769600 /gene="gntZ" /locus_tag="BSU_40080" /old_locus_tag="BSU40080" /EC_number="1.1.1.343" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:15231785, 9535092, 9931298" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15231785, 9535092, 9931298; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="6-phosphogluconate dehydrogenase (NAD+-dependent)" /protein_id="NP_391888.1" /db_xref="EnsemblGenomes-Gn:BSU40080" /db_xref="EnsemblGenomes-Tr:CAB16045" /db_xref="GOA:P12013" /db_xref="InterPro:IPR006113" /db_xref="InterPro:IPR006114" /db_xref="InterPro:IPR006115" /db_xref="InterPro:IPR006183" /db_xref="InterPro:IPR006184" /db_xref="InterPro:IPR008927" /db_xref="InterPro:IPR013328" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG10651" /db_xref="UniProtKB/Swiss-Prot:P12013" /translation="MFNSIGVIGLGVMGSNIALNMANKGENVAVYNYTRDLTDQLIQK LDGQSLSPYYELEDFVQSLEKPRKIFLMVTAGKPVDSVIQSLKPLLEEGDVIMDGGNS HYEDTERRYDELKEKGIGYLGVGISGGEVGALTGPSIMPGGDRDVYEKAAPILTKIAA QVGDDPCCVYIGPKGAGHFTKMVHNGIEYADMQLIAEAYTFLRETLRLPLDEIASIFE TWNQGELKSYLIEITAEILRKKDEKTGQPLIDVILDKTGQKGTGKWTSMQAIDNGIPS TIITESLFARYLSSLKEERMAAQDVLAGPEAEEKHLDKDTWIEYVRQALYMGKVCAYA QGFAQYKMSSELYGWNLPLKDIALIFRGGCIIRADFLNVISEAFSEQPNLANLLIAPY FTDKLHAYQTGLRKVVCEGISTGISFPCLTTALSYYDGYRTGRSNANLLQAQRDYFGA HTYERTDMDGVFHTNWSE*" /label="gntZ CDS" gene 3768194..3769600 /gene="gntZ" /locus_tag="BSU_40080" /old_locus_tag="BSU40080" /label="gntZ gene" downshifts 3769589 /Source="Nicolas_upshifts" /id="D2072" /incds=0 /nref=128 /ntot=228 /MaxReadThrough="3.81668" /MaxDrop="5.52642" /score="20.2280166" /energy="-10.2" /TU="NA" /idTUdmin="U3151" /TUdmin=0 /isTUend="TRUE" /label="downshifts" misc_feature 3769697..3769716 /Source="Nicolas_upshift_promotors" /id="U3153" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.898101898101898" /psig=1 /xcortree=620 /SigmaFactorBS="tttttttcttctatcccaaacaacagaagacataagttatgt tttaaatatcataaacAGTGATACAATAATAGCTAGaaacaatccccaagatcatcat g" /listShort="S1540" /listLong="ahpC, ahpF" /label="promotor_single_box" /note="Geneious type: promotor_single_box" S_feature 3769699..3769990 /Source="Nicolas_S_feature" /locus_tag="new_4118585_4118876" /HighExp="S8, Etha, Sw, T0.30H, Cold, H2O2, B60, S5, S4, BC" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1540" upshifts 3769699 /Source="Nicolas_upshifts" /id="U3153" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.898101898101898" /psig=1 /xcortree=620 /SigmaFactorBS="tttttttcttctatcccaaacaacagaagacataagttatgt tttaaatatcataaacAGTGATACAATAATAGCTAGaaacaatccccaagatcatcat g" /listShort="S1540" /listLong="ahpC, ahpF" /label="upshifts" promotor_-35 3769963..3769970 /Source="Nicolas_upshift_promotors" /id="U3154" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.532467532467532" /psig=1 /xcortree=2087 /SigmaFactorBS="cctttattaagatgaaaaaaagtaggttatgGCTTGACAaaa aatatatattaATTAATAATTCATATATAATtagaattattattgaaagcgattatgc t" /listShort="ahpC, ahpF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3769985..3770004 /Source="Nicolas_upshift_promotors" /id="U3154" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.532467532467532" /psig=1 /xcortree=2087 /SigmaFactorBS="cctttattaagatgaaaaaaagtaggttatgGCTTGACAaaa aatatatattaATTAATAATTCATATATAATtagaattattattgaaagcgattatgc t" /listShort="ahpC, ahpF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3769992 /Source="Nicolas_upshifts" /id="U3154" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.532467532467532" /psig=1 /xcortree=2087 /SigmaFactorBS="cctttattaagatgaaaaaaagtaggttatgGCTTGACAaaa aatatatattaATTAATAATTCATATATAATtagaattattattgaaagcgattatgc t" /listShort="ahpC, ahpF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3770014..3770021 /Source="Nicolas_upshift_promotors" /id="U3156" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.636363636363636" /psig="0.983016983016983" /xcortree=2089 /SigmaFactorBS="aattcatatataattagaattatTATTGAAAgcgattatgct ttcTAATACATTTTTAGGAGGAAtatacattatgtctttaatcggtaaagaagtactt c" /listShort="ahpC, ahpF" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3770036..3770055 /Source="Nicolas_upshift_promotors" /id="U3156" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.636363636363636" /psig="0.983016983016983" /xcortree=2089 /SigmaFactorBS="aattcatatataattagaattatTATTGAAAgcgattatgct ttcTAATACATTTTTAGGAGGAAtatacattatgtctttaatcggtaaagaagtactt c" /listShort="ahpC, ahpF" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3770039) /Source="Nicolas_upshifts" /id="U3155" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.914085914085914" /psig="0.047952047952048" /xcortree=299 /SigmaFactorBS="ttcgaatggaagtacttctttaccgattaaaGACATaatgta tATTCCTCCTAAAAATgtattagaaagcataatcgctttcaataataattctaattat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3770042..3770056) /Source="Nicolas_upshift_promotors" /id="U3155" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.914085914085914" /psig="0.047952047952048" /xcortree=299 /SigmaFactorBS="ttcgaatggaagtacttctttaccgattaaaGACATaatgta tATTCCTCCTAAAAATgtattagaaagcataatcgctttcaataataattctaattat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3770051 /Source="Nicolas_upshifts" /id="U3156" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.636363636363636" /psig="0.983016983016983" /xcortree=2089 /SigmaFactorBS="aattcatatataattagaattatTATTGAAAgcgattatgct ttcTAATACATTTTTAGGAGGAAtatacattatgtctttaatcggtaaagaagtactt c" /listShort="ahpC, ahpF" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3770064..3770068) /Source="Nicolas_upshift_promotors" /id="U3155" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.914085914085914" /psig="0.047952047952048" /xcortree=299 /SigmaFactorBS="ttcgaatggaagtacttctttaccgattaaaGACATaatgta tATTCCTCCTAAAAATgtattagaaagcataatcgctttcaataataattctaattat a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3770064..3770627 /gene="ahpC" /locus_tag="BSU_40090" /old_locus_tag="BSU40090" /EC_number="1.11.1.5" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8932315, 14766928, 26322180" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8932315, 14766928, 26322180; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alkyl hydroperoxide reductase (small subunit)" /protein_id="NP_391889.1" /db_xref="EnsemblGenomes-Gn:BSU40090" /db_xref="EnsemblGenomes-Tr:CAB16046" /db_xref="GOA:P80239" /db_xref="InterPro:IPR000866" /db_xref="InterPro:IPR013766" /db_xref="InterPro:IPR017559" /db_xref="InterPro:IPR019479" /db_xref="InterPro:IPR024706" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG11385" /db_xref="UniProtKB/Swiss-Prot:P80239" /translation="MSLIGKEVLPFEAKAFKNGEFIDVTNEDLKGQWSVFCFYPADFS FVCPTELEDLQEQYAALKELGVEVYSVSTDTHFVHKGWHDSSEKISKITYAMIGDPSQ TISRNFDVLDEETGLADRGTFIIDPDGVIQTVEINAGGIGRDASNLVNKVKAAQYVRQ NPGEVCPAKWEEGGETLTPSLDLVGKI*" /label="ahpC CDS" gene 3770064..3770627 /gene="ahpC" /locus_tag="BSU_40090" /old_locus_tag="BSU40090" /label="ahpC gene" CDS 3770641..3772170 /gene="ahpF" /locus_tag="BSU_40100" /old_locus_tag="BSU40100" /EC_number="1.6.99.3" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:8932314, 14766928, 16232966, 23899494" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8932314, 14766928, 16232966, 23899494; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="alkyl hydroperoxide reductase (large subunit)" /protein_id="NP_391890.1" /db_xref="EnsemblGenomes-Gn:BSU40100" /db_xref="EnsemblGenomes-Tr:CAB16047" /db_xref="GOA:P42974" /db_xref="InterPro:IPR000103" /db_xref="InterPro:IPR002109" /db_xref="InterPro:IPR008255" /db_xref="InterPro:IPR012081" /db_xref="InterPro:IPR012336" /db_xref="InterPro:IPR023753" /db_xref="InterPro:IPR036188" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG11204" /db_xref="UniProtKB/Swiss-Prot:P42974" /translation="MVLDANIKAQLNQYMQLIENDIVLKVSAGEDDTSKDMLALVDEL ASMSSKISVEKAELNRTPSFSVNRVGEDTGVTFAGIPLGHEFTSLVLALLQVSGRPPK VDQKVIDQVKKISGEYHFESYISLTCHNCPDVVQALNMMSVLNPNITHTMIDGAAYKA EVESKNIMAVPTVYLNGESFGSGRMTLEEILAKMGSGTDASEFADKEPFDVLVVGGGP AGASAAIYTARKGIRTGVVAERFGGQVLDTMSIENFISVKATEGPKLAASLEEHVKEY DIDVMNLQRAKRLEKKDLFELELENGAVLKSKTVILSTGARWRNVNVPGEQEFKNKGV AYCPHCDGPLFEGKDVAVIGGGNSGIEAAIDLAGIVNHVTVLEFAPELKADEVLQKRL YSLPNVTVVKNAQTKEITGDQSVNGITYVDRETGEEKHVELQGVFVQIGLVPNTEWLE GTVERNRMGEIIVDKHGATSVPGLFAAGDCTDSAYNQIIISMGSGATAALGAFDYLIR N*" /label="ahpF CDS" gene 3770641..3772170 /gene="ahpF" /locus_tag="BSU_40100" /old_locus_tag="BSU40100" /label="ahpF gene" downshifts complement(3771997) /Source="Nicolas_upshifts" /id="D2073" /incds=1 /nref=1 /ntot=9 /MaxReadThrough="3.25325" /MaxDrop="3.69049" /score="1.76901559" /energy="-18" /TU="NA" /idTUdmin="U3157" /TUdmin=198 /isTUend="FALSE" /label="downshifts" downshifts 3772163 /Source="Nicolas_upshifts" /id="D2074" /incds=0 /nref=248 /ntot=268 /MaxReadThrough="3.92009" /MaxDrop="8.88048" /score="33.1934883" /energy="-19.6" /TU="U3154" /idTUdmin="U3156" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(3772196..3772279) /Source="Nicolas_S_feature" /locus_tag="new_4121082_4121165_c" /HighExp="G150, C30, LPhT, G135, S8, LBGstat, T0.30H, G180, Diami, Oxctl" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1541" downshifts complement(3772239) /Source="Nicolas_upshifts" /id="D2075" /incds=0 /nref=1 /ntot=40 /MaxReadThrough="3.37922" /MaxDrop="4.44094" /score="1.76901559" /energy="-18" /TU="U3157" /idTUdmin="U3157" /TUdmin="-44" /isTUend="FALSE" /label="downshifts" CDS complement(3772280..3773719) /gene="bglA" /locus_tag="BSU_40110" /old_locus_tag="BSU40110" /EC_number="3.2.1.86" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:8125345, 14652714, 15139916" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 8125345, 14652714, 15139916; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="aryl-6-phospho-beta-glucosidase" /protein_id="NP_391891.1" /db_xref="EnsemblGenomes-Gn:BSU40110" /db_xref="EnsemblGenomes-Tr:CAB16048" /db_xref="GOA:P42973" /db_xref="InterPro:IPR001360" /db_xref="InterPro:IPR017853" /db_xref="InterPro:IPR018120" /db_xref="InterPro:IPR033132" /db_xref="SubtiList:BG11203" /db_xref="UniProtKB/Swiss-Prot:P42973" /translation="MGNMPKDFLWGGALAAHQFEGGWNQGGKGPSVVDVMTAGAHGVP RKITDTIEENEFYPNHEAIDFYHRYKEDIALFAEMGLKCLRTSIGWSRIFPKGDEAEP NEAGLQFYDDVFDELLKHGIEPVITLSHFEMPLHLAREYGGFRNRKVVDFFVNFAEAC FTRYKDKVKYWMTFNEINNQMDVNNPLFLWTNSGVVVGENENAKEVMYQTAHHELVAS ALAVAKGKDINPEFQIGAMVSHVPIYPFSSNPEDVMLAEEEMRQRYFFPDVQVRGYYP SYALKEFEREGYNITFEDGDDEILRNGTVDYLGFSYYMSTTVKSDVKNDNTGDIVNGG LPNGVENPYITSSDWGWAIDPTGLRYTLNRFYDRYQIPLFIVENGFGAVDTLEEDGKV HDPERIQYLKSHIEALKKAVTYDGVDLIGYTPWGIIDIVSFTTGEMKKRYGMIYVDRD NEGNGSMKRYKKDSFEWYKNVIQTNGEEL*" /label="bglA CDS" gene complement(3772280..3773719) /gene="bglA" /locus_tag="BSU_40110" /old_locus_tag="BSU40110" /label="bglA gene" CDS complement(3773733..3773963) /gene="ptsJ" /locus_tag="BSU_40120" /old_locus_tag="BSU40120" /EC_number="2.7.1.-" /function="16.3: Control" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:12867744, 28731580" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12867744, 28731580; Product type t: transporter" /codon_start=1 /transl_table=11 /product="glucose phosphotransferase system enzyme IIA component" /protein_id="NP_391892.1" /db_xref="EnsemblGenomes-Gn:BSU40120" /db_xref="EnsemblGenomes-Tr:CAB16049" /db_xref="GOA:O32292" /db_xref="InterPro:IPR001127" /db_xref="InterPro:IPR011055" /db_xref="SubtiList:BG14172" /db_xref="UniProtKB/Swiss-Prot:O32292" /translation="MVTPTKHAIGLRSASGVELLAHIGLDTVTFDGTPFSLKVKEGDT VKKGEVLVEFDKAFIEDIEESALHQKIFTVVS*" /label="ptsJ CDS" gene complement(3773733..3773963) /gene="ptsJ" /locus_tag="BSU_40120" /old_locus_tag="BSU40120" /label="ptsJ gene" S_feature complement(3773964..3774175) /Source="Nicolas_S_feature" /locus_tag="new_4122850_4123061_c" /HighExp="G150, LPhT, T0.30H, Diami, G135, LBGstat, G180, Oxctl, Lbexp, dia0" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1542" promotor_-10 complement(3774172..3774191) /Source="Nicolas_upshift_promotors" /id="U3157" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.811188811188811" /psig=1 /xcortree=1576 /SigmaFactorBS="tagtgcgtaaatattttgtttcggAATTGATAaattataccg ttacAATTATAATGAAAGCGTAACcaaaacgaaggggtgggtgaaatgtcggggaaag t" /listShort="S1542, yyzE, bglA, S1541" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3774177) /Source="Nicolas_upshifts" /id="U3157" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.811188811188811" /psig=1 /xcortree=1576 /SigmaFactorBS="tagtgcgtaaatattttgtttcggAATTGATAaattataccg ttacAATTATAATGAAAGCGTAACcaaaacgaaggggtgggtgaaatgtcggggaaag t" /listShort="S1542, yyzE, bglA, S1541" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3774206..3774213) /Source="Nicolas_upshift_promotors" /id="U3157" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.811188811188811" /psig=1 /xcortree=1576 /SigmaFactorBS="tagtgcgtaaatattttgtttcggAATTGATAaattataccg ttacAATTATAATGAAAGCGTAACcaaaacgaaggggtgggtgaaatgtcggggaaag t" /listShort="S1542, yyzE, bglA, S1541" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3774239..3774246 /Source="Nicolas_upshift_promotors" /id="U3158" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig=1 /xcortree=1557 /SigmaFactorBS="ttccgaaacaaaatatttacgcactaaCTATCATTgtaagcg gttTATGCTATAATTTTGACAAGtgaaactaaacgaataaatgaggaatgcgtatgtt a" /listShort="yydK, yyzN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3774257..3774276 /Source="Nicolas_upshift_promotors" /id="U3158" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig=1 /xcortree=1557 /SigmaFactorBS="ttccgaaacaaaatatttacgcactaaCTATCATTgtaagcg gttTATGCTATAATTTTGACAAGtgaaactaaacgaataaatgaggaatgcgtatgtt a" /listShort="yydK, yyzN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3774272 /Source="Nicolas_upshifts" /id="U3158" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.976023976023976" /psig=1 /xcortree=1557 /SigmaFactorBS="ttccgaaacaaaatatttacgcactaaCTATCATTgtaagcg gttTATGCTATAATTTTGACAAGtgaaactaaacgaataaatgaggaatgcgtatgtt a" /listShort="yydK, yyzN" /GFF_Attribute="listLong" /label="upshifts" CDS 3774307..3775017 /gene="yydK" /locus_tag="BSU_40130" /old_locus_tag="BSU40130" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (GntR family)" /protein_id="NP_391893.1" /db_xref="EnsemblGenomes-Gn:BSU40130" /db_xref="EnsemblGenomes-Tr:CAB16050" /db_xref="GOA:Q45591" /db_xref="InterPro:IPR000524" /db_xref="InterPro:IPR011663" /db_xref="InterPro:IPR028978" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:3BWG" /db_xref="SubtiList:BG11484" /db_xref="UniProtKB/Swiss-Prot:Q45591" /translation="MLKYQQIATEIETYIEEHQLQQGDKLPVLETLMAQFEVSKSTIT KSLELLEQKGAIFQVRGSGIFVRKHKRKGYISLLSNQGFKKDLEDFNVTSKVIELDVR KPTPEAAENLNIGMDEDIYYVKRVRYINGQTLCYEESYYTKSIVTYLNNEIVSHSIFH YIREGLGLKIGFSDLFLHVGQLNEEEAEYLGLEAGLPKLYIESIFHLTNGQPFDYSKI SYNYEQSQFVVQANSFLL*" /label="yydK CDS" gene 3774307..3775017 /gene="yydK" /locus_tag="BSU_40130" /old_locus_tag="BSU40130" /label="yydK gene" CDS 3775045..3775203 /gene="yyzN" /locus_tag="BSU_40139" /old_locus_tag="BSU40139" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097799.1" /db_xref="EnsemblGenomes-Gn:BSU40139" /db_xref="EnsemblGenomes-Tr:CAX52714" /db_xref="GOA:C0H3T8" /db_xref="UniProtKB/Swiss-Prot:C0H3T8" /translation="MYKIIIPAILAIFALWILLQISLEMSIVKNPMNYFIVFIIFFLF VKMVKEKQ*" /label="yyzN CDS" gene 3775045..3775203 /gene="yyzN" /locus_tag="BSU_40139" /old_locus_tag="BSU40139" /label="yyzN gene" downshifts 3775280 /Source="Nicolas_upshifts" /id="D2076" /incds=0 /nref=16 /ntot=177 /MaxReadThrough="0.96913" /MaxDrop="4.2349" /score="-9.95345673" /energy="-14.7" /TU="NA" /idTUdmin="U3158" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" CDS complement(3775334..3776056) /gene="liaM" /locus_tag="BSU_40140" /old_locus_tag="BSU40140" /function="16.1: Circulate" /function="16.3: Control" /function="16.4: Excrete" /experiment="publication(s) with functional evidences, PMID:15743949, 15849754, 16850406, 17921301, 28644475" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15743949, 15849754, 16850406, 17921301, 28644475; Product type t : transporter" /codon_start=1 /transl_table=11 /product="permease for export of regulatory peptide LiaD*" /protein_id="NP_391894.1" /db_xref="EnsemblGenomes-Gn:BSU40140" /db_xref="EnsemblGenomes-Tr:CAB16051" /db_xref="GOA:Q45592" /db_xref="SubtiList:BG11483" /db_xref="UniProtKB/Swiss-Prot:Q45592" /translation="MKLEFKKSISNKVIIILGAMFVFLFLLGYFLLVGIDKVSNVTPE MFFFSSYTVATQFGLMLFSFVIAFFINREYSNKNILFYKLIGENIYTFFYKKIAVLFL ECFAFITLGLLIISLMYHDFSHFALLLFLFSAVILQYILIIGTISVLCPNILISIGVS IVYWMTSVILVAISNKTFGFIAPFEAGNTMYPRIERVLQSDNMTLGSNDVLFIILYLV SIIIINAIVLRFSKTRWIKMGL*" /label="liaM CDS" gene complement(3775334..3776056) /gene="liaM" /locus_tag="BSU_40140" /old_locus_tag="BSU40140" /label="liaM gene" downshifts complement(3775346) /Source="Nicolas_upshifts" /id="D2077" /incds=0 /nref=225 /ntot=267 /MaxReadThrough="2.70741" /MaxDrop="6.21099" /score="7.49162587" /energy="-10.5" /TU="NA" /idTUdmin="U3160" /TUdmin="-5" /isTUend="TRUE" /label="downshifts" promotor_-35 3775957..3775960 /Source="Nicolas_upshift_promotors" /id="U3159" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.975024975024975" /psig="0.014985014985015" /xcortree=48 /SigmaFactorBS="tgtaacattactgactttatcgattcCAACaagtaaaaaata accCAGCAaaaataaaaatacaaacattgctcctaaaataatgataactttgttgcta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3775976..3775980 /Source="Nicolas_upshift_promotors" /id="U3159" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.975024975024975" /psig="0.014985014985015" /xcortree=48 /SigmaFactorBS="tgtaacattactgactttatcgattcCAACaagtaaaaaata accCAGCAaaaataaaaatacaaacattgctcctaaaataatgataactttgttgcta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3775991 /Source="Nicolas_upshifts" /id="U3159" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.975024975024975" /psig="0.014985014985015" /xcortree=48 /SigmaFactorBS="tgtaacattactgactttatcgattcCAACaagtaaaaaata accCAGCAaaaataaaaatacaaacattgctcctaaaataatgataactttgttgcta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3776077..3776706) /gene="liaL" /locus_tag="BSU_40150" /old_locus_tag="BSU40150" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:15743949, 15849754, 16850406, 17921301, 28644475" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15743949, 15849754, 16850406, 17921301, 28644475; Product type t : transporter" /codon_start=1 /transl_table=11 /product="ABC transporter for regulatory peptide LiaD* (ATP-binding protein)" /protein_id="NP_391895.1" /db_xref="EnsemblGenomes-Gn:BSU40150" /db_xref="EnsemblGenomes-Tr:CAB16052" /db_xref="GOA:Q45593" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11482" /db_xref="UniProtKB/Swiss-Prot:Q45593" /translation="MNIANYTLKVKGKTLLQDTDLHFSSGKINHVVGKNGVGKSQLAK DFLLNNSKRIGRDIRQNVSLISSSSNIPNDVSKDFLLHFLSKKFDAKMIDKIAYLLNL DNIDGKVLIKNLSDGQKQKLKLLSFLLEDKNIIVLDEITNSLDKKTVIEIHGFLNKYI QENPEKIIINITHDLSDLKAIEGDYYIFNHQEIQQYHSVDKLIEVYINE*" /label="liaL CDS" gene complement(3776077..3776706) /gene="liaL" /locus_tag="BSU_40150" /old_locus_tag="BSU40150" /label="liaL gene" S_feature complement(3776707..3776855) /Source="Nicolas_S_feature" /locus_tag="new_4125593_4125741_c" /HighExp="T-0.40H, LoTm, T-2.40H, T0.0H, M9-tran, SMMPr, T-1.40H, GM 150, T-3.40H, T-4.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1543" CDS complement(3776856..3777614) /gene="liaK" /locus_tag="BSU_40160" /old_locus_tag="BSU40160" /function="16.3: Control" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:15743949, 15849754, 16850406, 17921301, 28644475" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15743949, 15849754, 16850406, 17921301, 28644475; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="membrane metalloprotease acting on modified factor LiaD" /protein_id="NP_391896.2" /db_xref="EnsemblGenomes-Gn:BSU40160" /db_xref="EnsemblGenomes-Tr:CAB16053" /db_xref="GOA:Q45594" /db_xref="SubtiList:BG11481" /db_xref="UniProtKB/Swiss-Prot:Q45594" /translation="MKILKYEDEKYEVLVQNNVFIKDKKSGEYYKNSLNSLSDKQLLR FKMYKEKVSPKFFYLFLSFTALMFILNYIHLIKLQNGLSSVFYGWKMWIIIVIYFIMN IVLHELGHIYSLKFFGKNFDKVGFKLNFYVFPAFYVQLNETYMLSRNEKIIVHLFGLF INYLLINTLELINQFTFSSEALTMAFMLFSSTLLWNLIPILNSDGYKILLAFLSLDEY SRFKTNHWLVLTIQIIGIGLAVNSVVHWILYIVN*" /label="liaK CDS" gene complement(3776856..3777614) /gene="liaK" /locus_tag="BSU_40160" /old_locus_tag="BSU40160" /label="liaK gene" promotor_-10 complement(3777304..3777323) /Source="Nicolas_upshift_promotors" /id="U3160" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig=1 /xcortree=2954 /SigmaFactorBS="caaaatggattgtcctcagtattttacggctggaaaaTGTGG ATAattatagttattTATTTTATAATGAATATAGTgcttcatgaactgggacatattt a" /listShort="S1543, yydI, yydJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3777320) /Source="Nicolas_upshifts" /id="U3160" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig=1 /xcortree=2954 /SigmaFactorBS="caaaatggattgtcctcagtattttacggctggaaaaTGTGG ATAattatagttattTATTTTATAATGAATATAGTgcttcatgaactgggacatattt a" /listShort="S1543, yydI, yydJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3777336..3777343) /Source="Nicolas_upshift_promotors" /id="U3160" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.353646353646354" /psig=1 /xcortree=2954 /SigmaFactorBS="caaaatggattgtcctcagtattttacggctggaaaaTGTGG ATAattatagttattTATTTTATAATGAATATAGTgcttcatgaactgggacatattt a" /listShort="S1543, yydI, yydJ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3777595..3778554) /gene="liaE" /locus_tag="BSU_40170" /old_locus_tag="BSU40170" /EC_number="5.1.1.-" /experiment="publication(s) with functional evidences, PMID:17921301, 18307109, 28644475" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 17921301, 18307109, 28644475; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="AdoMet radical amino acid epimerase modifying factor LiaD" /protein_id="NP_391897.1" /db_xref="EnsemblGenomes-Gn:BSU40170" /db_xref="EnsemblGenomes-Tr:CAB16054" /db_xref="GOA:Q45595" /db_xref="InterPro:IPR007197" /db_xref="InterPro:IPR023404" /db_xref="InterPro:IPR023904" /db_xref="InterPro:IPR034395" /db_xref="SubtiList:BG11480" /db_xref="UniProtKB/Swiss-Prot:Q45595" /translation="MYNKTVSINLDSRCNASCDHCCFSSSPTSTTRMEKEYIRELVTE FAKNKTIQVISFTGGEVFLDYKFLKELMEIIKPYEKQITLISNGFWGLSKKKVQEYFH DMNSLNVIALTISYDEYHAPFVKSSSIKNILEHSRKYPDIDISLNMAVTKDKMSNHIL EELGDSILGVKITKFPMISVGAAKTRIKQENIHKFYSLEDEDSLHCPGYDIVYHHDGE IYPCCSPAIFETKITLREEYNQSFERTVEKLNSNLLLFILRKEGFKWFLNILKENNKI EEFDIPYEFSSICGVCGSLFNSAEKINYFYPYMEKYYNENFKV*" /label="liaE CDS" gene complement(3777595..3778554) /gene="liaE" /locus_tag="BSU_40170" /old_locus_tag="BSU40170" /label="liaE gene" downshifts 3778543 /Source="Nicolas_upshifts" /id="D2078" /incds=0 /nref=1 /ntot=14 /MaxReadThrough="3.40583" /MaxDrop="2.5017" /score="-9.12840375" /energy="-9.4" /TU="NA" /idTUdmin="U3161" /TUdmin="-220" /isTUend="FALSE" /label="downshifts" misc_feature 3778590..3778593 /Source="Nicolas_upshift_promotors" /id="U3161" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.380619380619381" /psig="0.304695304695305" /xcortree=119 /SigmaFactorBS="actgttttattatacatgaaatatcccccaacaaatggtaaa ggagagttagACTCtcctttgtacccctctaattaatgaccacttccaagaatccagc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3778598 /Source="Nicolas_upshifts" /id="U3161" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.380619380619381" /psig="0.304695304695305" /xcortree=119 /SigmaFactorBS="actgttttattatacatgaaatatcccccaacaaatggtaaa ggagagttagACTCtcctttgtacccctctaattaatgaccacttccaagaatccagc g" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3778612..3778761) /gene="liaD" /locus_tag="BSU_40180" /old_locus_tag="BSU40180" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:15101989, 17921301, 28644475" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 15101989, 17921301, 28644475; Product type r: regulator" /codon_start=1 /transl_table=11 /product="precursor of exported modified peptide (epipeptide) controlling LiaRS activity" /protein_id="NP_391898.1" /db_xref="EnsemblGenomes-Gn:BSU40180" /db_xref="EnsemblGenomes-Tr:CAB16055" /db_xref="InterPro:IPR023898" /db_xref="SubtiList:BG11479" /db_xref="UniProtKB/Swiss-Prot:Q45596" /translation="MKKEITNNETVKNLEFKGLLDESQKLAKVNDLWYFVKSKENRWI LGSGH*" /label="liaD CDS" gene complement(3778612..3778761) /gene="liaD" /locus_tag="BSU_40180" /old_locus_tag="BSU40180" /label="liaD gene" downshifts complement(3778619) /Source="Nicolas_upshifts" /id="D2079" /incds=0 /nref=99 /ntot=172 /MaxReadThrough="7.62324" /MaxDrop="6.01674" /score="7.49162587" /energy="-10.5" /TU="U3163" /idTUdmin="U3167" /TUdmin=2794 /isTUend="FALSE" /label="downshifts" misc_feature 3778670..3778687 /Source="Nicolas_upshift_promotors" /id="U3162" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.342657342657343" /psig="0.342657342657343" /xcortree=651 /SigmaFactorBS="atgaccacttccaagaatccagcgattttcttttgattttac aaaataccaaagaTCATTCACTTTTGCTAACttttgtgattcatctaatagaccctta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3778675 /Source="Nicolas_upshifts" /id="U3162" /multdbtbs="-" /comp="M3" /sig="Sig-" /pcomp="0.342657342657343" /psig="0.342657342657343" /xcortree=651 /SigmaFactorBS="atgaccacttccaagaatccagcgattttcttttgattttac aaaataccaaagaTCATTCACTTTTGCTAACttttgtgattcatctaatagaccctta a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" downshifts 3778756 /Source="Nicolas_upshifts" /id="D2080" /incds=0 /nref=99 /ntot=170 /MaxReadThrough="2.55247" /MaxDrop="5.95806" /score="-9.12840375" /energy="-9.4" /TU="NA" /idTUdmin="U3161" /TUdmin="-7" /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3778782..3778801) /Source="Nicolas_upshift_promotors" /id="U3163" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2870 /SigmaFactorBS="ccaagaatagtgacatttttcagattttttaggtacaataTA TTGACAtgtattgaatgataTAGAATAATTGGTTTATATTagaaaaggaggagggata a" /listShort="yydF, yydG, yydH, S1543, yydI, yydJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3778803) /Source="Nicolas_upshifts" /id="U3163" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2870 /SigmaFactorBS="ccaagaatagtgacatttttcagattttttaggtacaataTA TTGACAtgtattgaatgataTAGAATAATTGGTTTATATTagaaaaggaggagggata a" /listShort="yydF, yydG, yydH, S1543, yydI, yydJ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3778816..3778823) /Source="Nicolas_upshift_promotors" /id="U3163" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.998001998001998" /psig=1 /xcortree=2870 /SigmaFactorBS="ccaagaatagtgacatttttcagattttttaggtacaataTA TTGACAtgtattgaatgataTAGAATAATTGGTTTATATTagaaaaggaggagggata a" /listShort="yydF, yydG, yydH, S1543, yydI, yydJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3779096..3779103 /Source="Nicolas_upshift_promotors" /id="U3164" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=1990 /SigmaFactorBS="tgcttaccccatttggcacctctttctctcgtttTAATTGTC tctaaaagcagttaTGCGGTACTATCATATAAAGgtccaatgtttaaaaataatgtca t" /listShort="fbp, S1544" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3779118..3779137 /Source="Nicolas_upshift_promotors" /id="U3164" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=1990 /SigmaFactorBS="tgcttaccccatttggcacctctttctctcgtttTAATTGTC tctaaaagcagttaTGCGGTACTATCATATAAAGgtccaatgtttaaaaataatgtca t" /listShort="fbp, S1544" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3779122 /Source="Nicolas_upshifts" /id="U3164" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.924075924075924" /psig=1 /xcortree=1990 /SigmaFactorBS="tgcttaccccatttggcacctctttctctcgtttTAATTGTC tctaaaagcagttaTGCGGTACTATCATATAAAGgtccaatgtttaaaaataatgtca t" /listShort="fbp, S1544" /GFF_Attribute="listLong" /label="upshifts" CDS 3779233..3781158 /gene="fbp" /locus_tag="BSU_40190" /old_locus_tag="BSU40190" /EC_number="3.1.3.11" /function="16.3: Control" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:221467, 9696785, 19270101" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 221467, 9696785, 19270101; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="fructose-1,6-bisphosphatase" /protein_id="NP_391899.2" /db_xref="EnsemblGenomes-Gn:BSU40190" /db_xref="EnsemblGenomes-Tr:CAB16056" /db_xref="GOA:Q45597" /db_xref="InterPro:IPR009164" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG11478" /db_xref="UniProtKB/Swiss-Prot:Q45597" /translation="MESKYLDLLAQKYDCEEKVVTEIINLKAILNLPKGTEHFVSDLH GEYQAFQHVLRNGSGRVKEKIRDIFSGVIYDREIDELAALVYYPEDKLKLIKHDFDAK EALNEWYKETIHRMIKLVSYCSSKYTRSKLRKALPAQFAYITEELLYKTEQAGNKEQY YSEIIDQIIELGQADKLITGLAYSVQRLVVDHLHVVGDIYDRGPQPDRIMEELINYHS VDIQWGNHDVLWIGAYSGSKVCLANIIRICARYDNLDIIEDVYGINLRPLLNLAEKYY DDNPAFRPKADENRPEDEIKQITKIHQAIAMIQFKLESPIIKRRPNFNMEERLLLEKI DYDKNEITLNGKTYQLENTCFATINPEQPDQLLEEEAEVIDKLLFSVQHSEKLGRHMN FMMKKGSLYLKYNGNLLIHGCIPVDENGNMETMMIEDKPYAGRELLDVFERFLREAFA HPEETDDLATDMAWYLWTGEYSSLFGKRAMTTFERYFIKEKETHKEKKNPYYYLREDE ATCRNILAEFGLNPDHGHIINGHTPVKEIEGEDPIKANGKMIVIDGGFSKAYQSTTGI AGYTLLYNSYGMQLVAHKHFNSKAEVLSTGTDVLTVKRLVDKELERKKVKETNVGEEL LQEVAILESLREYRYMK*" /label="fbp CDS" gene 3779233..3781158 /gene="fbp" /locus_tag="BSU_40190" /old_locus_tag="BSU40190" /label="fbp gene" S_feature 3781159..3782523 /Source="Nicolas_S_feature" /locus_tag="new_4130045_4131409" /HighExp="Lbstat, dia5, C30, Gly, Etha, dia15, C90, Fru, G135, Mal" /AntisenseName="yydD" /AntisenseCor="0.44422072328838003" /AntisenseRegPval="-13.7" /CDS_PredictionProba="0.22050400000000001" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1544" S_feature complement(3781371..3781691) /Source="Nicolas_S_feature" /locus_tag="new_4130257_4130577_c" /HighExp="Cold, C30, M/G, S8, Fru, nit, Glu, BMM, Heat, MG 150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S1545" CDS complement(3781692..3783452) /gene="yydD" /locus_tag="BSU_40200" /old_locus_tag="BSU40200" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative DNA wielding protein" /protein_id="NP_391900.1" /db_xref="EnsemblGenomes-Gn:BSU40200" /db_xref="EnsemblGenomes-Tr:CAB16057" /db_xref="InterPro:IPR018760" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG11477" /db_xref="UniProtKB/Swiss-Prot:Q45598" /translation="MIVMIIKNLFVCNSQEILKEYKFNAVGVNIILGEKREDHEETNG VGKSTMIECISFLLGKTISNFYTTNEILLNKNVFIVLNVEIDGNQVFLARSFNSPKHG YTLHDTSLTFNLEEWKKVSISVYKKFIEKEILKGEKEDITFAALREYIIRDEKTGFND IVLPNRGGLKQYKLLNYLFTLPTHTEKNIKVFRDKIEKLNSEIKLIESMNINIGDLKV KEDELINEIEDYNRVIYQTKTANKYNNDTNRYSEIKSELNKIQNEIFENEHICKQYQR NIDDLNKKVTKIKELENIEKFYEDIVGFFPEEVKQNYNKVQEFYNFMVESRGSYFKDK IVKIQADLKKLNIKKQGLTEQLESSARILKSNNFIEDISIVMEEQRRKEIELAEVRLR ISDYDKKNHIFDKINELQHEILRVNSMYYDEFQSYSAIVSELKKLFNNLMDVTYNQHG FLDFEYDNRISNAKQSTTGRIKISCSIPDERSHGRLHMKINIFDLTWFLYRCINKCSL NILIHDGSYSNPDPHVKGTLLKHINSSLLENRIGQYFVTINKNELLLDDLQELESKGM IVAKLDRNNEDKNRFFGFRF*" /label="yydD CDS" gene complement(3781692..3783452) /gene="yydD" /locus_tag="BSU_40200" /old_locus_tag="BSU40200" /label="yydD gene" downshifts complement(3781735) /Source="Nicolas_upshifts" /id="D2081" /incds=0 /nref=11 /ntot=199 /MaxReadThrough="4.99391" /MaxDrop="4.47843" /score="7.49162587" /energy="-10.5" /TU="U3167" /idTUdmin="U3167" /TUdmin="-322" /isTUend="FALSE" /label="downshifts" misc_feature 3782520..3782521 /Source="Nicolas_upshift_promotors" /id="U3165" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.67032967032967" /psig="0.255744255744256" /xcortree=83 /SigmaFactorBS="aactccctctactttctaccatgaaattatagaactcttgga ctttattataattCTgttttacttcctctggaaaaaaacctacaatatcttcatagaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3782525 /Source="Nicolas_upshifts" /id="U3165" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.67032967032967" /psig="0.255744255744256" /xcortree=83 /SigmaFactorBS="aactccctctactttctaccatgaaattatagaactcttgga ctttattataattCTgttttacttcctctggaaaaaaacctacaatatcttcatagaa t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3783452..3783850) /gene="yydC" /locus_tag="BSU_40210" /old_locus_tag="BSU40210" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391901.1" /db_xref="EnsemblGenomes-Gn:BSU40210" /db_xref="EnsemblGenomes-Tr:CAB16058" /db_xref="SubtiList:BG11476" /db_xref="UniProtKB/Swiss-Prot:Q45599" /translation="MIDLKIETAENILKYSYVLLENEFKNIQIGNDLIPLVNNSPLKK EKAERPEMNHFLLTKYNAVEENILYSSKILYELLEKEKHIDQLFLDYAKSQGIIINLN IERILYLSLTFLYSLGKVSFNQNMISRTES*" /label="yydC CDS" gene complement(3783452..3783850) /gene="yydC" /locus_tag="BSU_40210" /old_locus_tag="BSU40210" /label="yydC gene" CDS complement(3783843..3785288) /gene="yydB" /locus_tag="BSU_40220" /old_locus_tag="BSU40220" /function="16.11: Scavenge (Catabolism)" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative phosphohydrolase" /protein_id="NP_391902.1" /db_xref="EnsemblGenomes-Gn:BSU40220" /db_xref="EnsemblGenomes-Tr:CAB16059" /db_xref="GOA:Q45600" /db_xref="InterPro:IPR004843" /db_xref="InterPro:IPR029052" /db_xref="SubtiList:BG11475" /db_xref="UniProtKB/Swiss-Prot:Q45600" /translation="MKVRFLQISDLHFQFQNYDTIVMRDKLLDFIEVLRRESDFDFLL LTGDIAHKGDVYNEDVKEYLNGIIKSMGLSKNNVHLVPGNHDISRDMTRTLLIDSIMK SPNPSEMLDKLDQKATNILVEGQRKFFDFYEDFMGVKYPEEDLHFLYQSEKYNVLSIN TCLLSDKKGEEGTLLTAQMKLYKAIRKMNKEKNKGKVLNIAIGHHTLGCIESSERESI KAHFDDYFIDLYLAGHVHDSSFNITANTNENPFLELVSGAIIKDEYATPEFISVDVNL DNGETEVTYYIWNTEYKYWSKNNQGGRRLQEGKLNYKINRLESLIEKEIEDNDDKIDE DEFKSFIIDFHEYRESYKTFTSNFDNQIGLDKKFYDMKSGETFKRKFDSYSEYFGVIN HIMDSTSYVSADKKELIAETIVDKYLEFHNQYNNGDEIFVKIVNEIYLECHSVLPYSK ALTKKYIKILTCWCIYECEIFNDNKRSVKND*" /label="yydB CDS" gene complement(3783843..3785288) /gene="yydB" /locus_tag="BSU_40220" /old_locus_tag="BSU40220" /label="yydB gene" promotor_-35 3784538..3784545 /Source="Nicolas_upshift_promotors" /id="U3166" /multdbtbs="-" /comp="M11" /sig="Sig-" /pcomp="0.353646353646354" /psig="0.430569430569431" /xcortree=94 /SigmaFactorBS="tttataatggctccacttactaattctaagaATGGATTTtca tttgtattTGCAGTAATATTAAATGAAGaatcatgtacatgtcctgccaaatatagat c" /listShort="S1546" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3784557..3784576 /Source="Nicolas_upshift_promotors" /id="U3166" /multdbtbs="-" /comp="M11" /sig="Sig-" /pcomp="0.353646353646354" /psig="0.430569430569431" /xcortree=94 /SigmaFactorBS="tttataatggctccacttactaattctaagaATGGATTTtca tttgtattTGCAGTAATATTAAATGAAGaatcatgtacatgtcctgccaaatatagat c" /listShort="S1546" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3784567..3785616 /Source="Nicolas_S_feature" /locus_tag="new_4133453_4134502" /HighExp="C30, Salt, Gly, S8, Etha, LPhT, T0.30H, Heat, C90, M9-stat" /AntisenseName="yydB" /AntisenseCor="0.36202116146901597" /AntisenseRegPval="-9" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.431" /TUlongSig="NA" /TUlongPSig="NA" /label="S1546" upshifts 3784567 /Source="Nicolas_upshifts" /id="U3166" /multdbtbs="-" /comp="M11" /sig="Sig-" /pcomp="0.353646353646354" /psig="0.430569430569431" /xcortree=94 /SigmaFactorBS="tttataatggctccacttactaattctaagaATGGATTTtca tttgtattTGCAGTAATATTAAATGAAGaatcatgtacatgtcctgccaaatatagat c" /listShort="S1546" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3785289..3785549) /Source="Nicolas_S_feature" /locus_tag="new_4134175_4134435_c" /HighExp="Cold, M0t90, Lbtran, M40t90, Lbstat, T0.30H, MG 150, M40t45, Gly, M0t45" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S1547" CDS complement(3785550..3786029) /gene="rlmH" /locus_tag="BSU_40230" /old_locus_tag="BSU40230" /EC_number="2.1.1.177" /function="16.6: Maintain" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 18755835, 20817755, 22411911, 22720735, 28428565; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="23S rRNA (pseudouridine1915-N3)-methyltransferase" /protein_id="NP_391903.1" /db_xref="EnsemblGenomes-Gn:BSU40230" /db_xref="EnsemblGenomes-Tr:CAB16060" /db_xref="GOA:Q45601" /db_xref="InterPro:IPR003742" /db_xref="InterPro:IPR029026" /db_xref="InterPro:IPR029028" /db_xref="PDB:1TO0" /db_xref="SubtiList:BG11474" /db_xref="UniProtKB/Swiss-Prot:Q45601" /translation="MNINIVTIGKLKEKYLKQGIEEYTKRLSAYAKIDIIELPDEKAP ENLSDQDMKIIKDKEGDRILSKISPDAHVIALAIEGKMKTSEELADTIDKLATYGKSK VTFVIGGSLGLSDTVMKRADEKLSFSKMTFPHQLMRLILVEQIYRAFRINRGEPYHK* " /label="rlmH CDS" gene complement(3785550..3786029) /gene="rlmH" /locus_tag="BSU_40230" /old_locus_tag="BSU40230" /label="rlmH gene" S_feature complement(3786030..3786109) /Source="Nicolas_S_feature" /locus_tag="new_4134916_4134995_c" /HighExp="dia5, LBGtran, T0.30H, Diami, Cold, M0t90, dia0, M0t45, M40t45, Lbtran" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.988" /TUlongSig="NA" /TUlongPSig="NA" /label="S1548" CDS complement(3786110..3786280) /gene="yyzF" /locus_tag="BSU_40239" /old_locus_tag="BSU40239" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="YP_003097800.1" /db_xref="EnsemblGenomes-Gn:BSU40239" /db_xref="EnsemblGenomes-Tr:CAX52715" /db_xref="InterPro:IPR025626" /db_xref="UniProtKB/Swiss-Prot:C0H3T9" /translation="MKQAYYSCEEHIETVLDMYIDDHELPPEIRKIEHTNSLSTACEL CGDPAVYIVGNE*" /label="yyzF CDS" gene complement(3786110..3786280) /gene="yyzF" /locus_tag="BSU_40239" /old_locus_tag="BSU40239" /label="yyzF gene" promotor_-10 complement(3786321..3786340) /Source="Nicolas_upshift_promotors" /id="U3167" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.343656343656344" /psig="0.988011988011988" /xcortree=2306 /SigmaFactorBS="ttgtttgtcgaattgtggataaaactcagcccgaagcaCTAC TAacatgtgaataaaTAGGTTATATTGAGAAGAGAacatttgtaaaaatggaagaaaa c" /listShort="yyzF, S1548, yydA, S1547, yydB, yydC, yydD, S1545" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3786337) /Source="Nicolas_upshifts" /id="U3167" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.343656343656344" /psig="0.988011988011988" /xcortree=2306 /SigmaFactorBS="ttgtttgtcgaattgtggataaaactcagcccgaagcaCTAC TAacatgtgaataaaTAGGTTATATTGAGAAGAGAacatttgtaaaaatggaagaaaa c" /listShort="yyzF, S1548, yydA, S1547, yydB, yydC, yydD, S1545" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3786354..3786359) /Source="Nicolas_upshift_promotors" /id="U3167" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.343656343656344" /psig="0.988011988011988" /xcortree=2306 /SigmaFactorBS="ttgtttgtcgaattgtggataaaactcagcccgaagcaCTAC TAacatgtgaataaaTAGGTTATATTGAGAAGAGAacatttgtaaaaatggaagaaaa c" /listShort="yyzF, S1548, yydA, S1547, yydB, yydC, yydD, S1545" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3786403..3786410 /Source="Nicolas_upshift_promotors" /id="U3168" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.549450549450549" /psig="0.994005994005994" /xcortree=415 /SigmaFactorBS="ccacaattcgacaaacaagctgtTGATGACTctatttcgctc gTGTGTTAGTTTGGATGTAACcgatgtgtggggaggtctgcatttgcgctttagatgg g" /listShort="yycS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3786423..3786442 /Source="Nicolas_upshift_promotors" /id="U3168" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.549450549450549" /psig="0.994005994005994" /xcortree=415 /SigmaFactorBS="ccacaattcgacaaacaagctgtTGATGACTctatttcgctc gTGTGTTAGTTTGGATGTAACcgatgtgtggggaggtctgcatttgcgctttagatgg g" /listShort="yycS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3786440 /Source="Nicolas_upshifts" /id="U3168" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.549450549450549" /psig="0.994005994005994" /xcortree=415 /SigmaFactorBS="ccacaattcgacaaacaagctgtTGATGACTctatttcgctc gTGTGTTAGTTTGGATGTAACcgatgtgtggggaggtctgcatttgcgctttagatgg g" /listShort="yycS" /GFF_Attribute="listLong" /label="upshifts" CDS 3786465..3786878 /gene="yycS" /locus_tag="BSU_40240" /old_locus_tag="BSU40240" /function="16.5: Explore" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 21911367; Product type s: structure" /codon_start=1 /transl_table=11 /product="putative lipoprotein" /protein_id="NP_391904.1" /db_xref="EnsemblGenomes-Gn:BSU40240" /db_xref="EnsemblGenomes-Tr:CAB16061" /db_xref="SubtiList:BG11472" /db_xref="UniProtKB/Swiss-Prot:Q45603" /translation="MRFRWVWLFVIMLLLAECQPSYWVLEKDRIGEGSPDLEIYANYL QMHDDVKGYQVFTISEGKKMVVVSLGSSEKDKKLEVSDVKFSSKETIVTVERKPAPTA NEKNPFILIGLDKIEGDLIVQDETGDRFEETDYQQ*" /label="yycS CDS" gene 3786465..3786878 /gene="yycS" /locus_tag="BSU_40240" /old_locus_tag="BSU40240" /label="yycS gene" downshifts 3786858 /Source="Nicolas_upshifts" /id="D2082" /incds=0 /nref=17 /ntot=131 /MaxReadThrough="1.50241" /MaxDrop="5.73792" /score="16.0382598" /energy="-10.8" /TU="NA" /idTUdmin="U3168" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3786912..3788138) /gene="yycR" /locus_tag="BSU_40250" /old_locus_tag="BSU40250" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 18820069; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative dehydrogenase" /protein_id="NP_391905.1" /db_xref="EnsemblGenomes-Gn:BSU40250" /db_xref="EnsemblGenomes-Tr:CAB16062" /db_xref="GOA:Q45604" /db_xref="InterPro:IPR002328" /db_xref="InterPro:IPR011032" /db_xref="InterPro:IPR013149" /db_xref="InterPro:IPR013154" /db_xref="InterPro:IPR014184" /db_xref="InterPro:IPR036291" /db_xref="SubtiList:BG11471" /db_xref="UniProtKB/Swiss-Prot:Q45604" /translation="MGGMALTGNKAVVYKGKGTVAVEDIGYPELILRDGPGVPKANVN RKCEHGVILKVITTNICGSDQHMVRGRTTAPEGLVLGHEITGEVIETGRDVEFIKKGD IVSVPFNIACGRCVMCKTQKTHVCLNVNPDRPGSAYGYVDMGGWVGGQSEYVMVPYAD FQLLVFPDKEQALEKILDLTMLSDIFPTGFHGAYTAGVQTGSTVYIAGAGPVGLAAAH SAQLLGASTVIVGDLNEDRLAQARSFGCETVNVQKHDRLGEQIEQILGEPTVDAAVDC VGFEASGHGNQGEAPAAVLNSIMDVTQVGGSLGIPGLYVTEDPGAKDADAKTGSLKIR FGLGWAKAHTFVTGQTPAMTYNRNLMKAILSGRAQIAKAVNATVISLDDAPKGYSDFD KGAAKKFVIDPHGTLK*" /label="yycR CDS" gene complement(3786912..3788138) /gene="yycR" /locus_tag="BSU_40250" /old_locus_tag="BSU40250" /label="yycR gene" downshifts complement(3786927) /Source="Nicolas_upshifts" /id="D2083" /incds=0 /nref=9 /ntot=123 /MaxReadThrough="0.14321" /MaxDrop="4.77892" /score="8.82768619" /energy="-6.2" /TU="NA" /idTUdmin="U3169" /TUdmin=7 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3788161..3788179) /Source="Nicolas_upshift_promotors" /id="U3169" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=518 /SigmaFactorBS="taagaatacagaaaaaacagtcgtgaaAAAGGGAAAgagtca tgccgAACCGAAGTCATGTTCAAGgacggagagtccaaacacatgaatgggaggaatg g" /listShort="yycR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3788166) /Source="Nicolas_upshifts" /id="U3169" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=518 /SigmaFactorBS="taagaatacagaaaaaacagtcgtgaaAAAGGGAAAgagtca tgccgAACCGAAGTCATGTTCAAGgacggagagtccaaacacatgaatgggaggaatg g" /listShort="yycR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3788191..3788199) /Source="Nicolas_upshift_promotors" /id="U3169" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=518 /SigmaFactorBS="taagaatacagaaaaaacagtcgtgaaAAAGGGAAAgagtca tgccgAACCGAAGTCATGTTCAAGgacggagagtccaaacacatgaatgggaggaatg g" /listShort="yycR" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3788201..3788371) /gene="yyzG" /locus_tag="BSU_40259" /old_locus_tag="BSU40259" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097801.1" /db_xref="EnsemblGenomes-Gn:BSU40259" /db_xref="EnsemblGenomes-Tr:CAX52716" /db_xref="GOA:C0H3U0" /db_xref="UniProtKB/Swiss-Prot:C0H3U0" /translation="MQTNRVILLAVMICLVSAITVFLLNGCKVDFLDIGGTIIGCFLG IFVVVRIQKKQS*" /label="yyzG CDS" gene complement(3788201..3788371) /gene="yyzG" /locus_tag="BSU_40259" /old_locus_tag="BSU40259" /label="yyzG gene" promotor_-10 complement(3788390..3788408) /Source="Nicolas_upshift_promotors" /id="U3170" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.681318681318681" /psig="0.681318681318681" /xcortree=259 /SigmaFactorBS="ttatgaagagactggtgtgaagtctctttttttgttgaacCG AAGTTtgcagaggattttGGGTATGGTTTAGAAACGAatccaaaggaggaattacatg c" /listShort="yyzG, yycR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3788408) /Source="Nicolas_upshifts" /id="U3170" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.681318681318681" /psig="0.681318681318681" /xcortree=259 /SigmaFactorBS="ttatgaagagactggtgtgaagtctctttttttgttgaacCG AAGTTtgcagaggattttGGGTATGGTTTAGAAACGAatccaaaggaggaattacatg c" /listShort="yyzG, yycR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3788422..3788428) /Source="Nicolas_upshift_promotors" /id="U3170" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp="0.681318681318681" /psig="0.681318681318681" /xcortree=259 /SigmaFactorBS="ttatgaagagactggtgtgaagtctctttttttgttgaacCG AAGTTtgcagaggattttGGGTATGGTTTAGAAACGAatccaaaggaggaattacatg c" /listShort="yyzG, yycR" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3788476..3788724) /gene="yycQ" /locus_tag="BSU_40260" /old_locus_tag="BSU40260" /function="18: Unknown function" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="conserved membrane protein" /protein_id="NP_391906.1" /db_xref="EnsemblGenomes-Gn:BSU40260" /db_xref="EnsemblGenomes-Tr:CAB16063" /db_xref="GOA:Q45605" /db_xref="InterPro:IPR020258" /db_xref="SubtiList:BG11470" /db_xref="UniProtKB/Swiss-Prot:Q45605" /translation="MGAIAVLFIVFGFPIVAGVFGIAGHFLFKRFWVAPLIVLITSLI LLVTLASGNSSFIFWVVMYTAIALVTSVATLFLRKFFE*" /label="yycQ CDS" gene complement(3788476..3788724) /gene="yycQ" /locus_tag="BSU_40260" /old_locus_tag="BSU40260" /label="yycQ gene" CDS complement(3788740..3789903) /gene="yycP" /locus_tag="BSU_40270" /old_locus_tag="BSU40270" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11557812, 16291680" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391907.2" /db_xref="EnsemblGenomes-Gn:BSU40270" /db_xref="EnsemblGenomes-Tr:CAB16064" /db_xref="InterPro:IPR011047" /db_xref="SubtiList:BG11469" /db_xref="UniProtKB/Swiss-Prot:Q45606" /translation="MKKWMITIAMLILAGIALFVFISPLKSHKTVSQQDLRNPDFLDD KEVLLYFSSSADQDAFGGGKSYALFISHDGTLSSFQMKGLELGSAKVHGDSVMLEDKN TIYTIKNGLRSHKRTYQHTGDSAGFLQNTDGFYTLYNSGYDKKGDGYRSELYRQMDGE WKKDVIPYYIRASGFHDGAIYALVPTDDGKGYQLLQIQADQKKLTYLSITEWQYREGA SVESQLAVDDQAVYVMVRGQKAHDLYQMVKINKKSGEVELHDIAEYKNDEQTIYSSMP FSFKNSFFPYDGNLYFIDGFGKVHKIDAKTGKTSIVFTLSPDKMKAEFKEITQKGSSL YFFTYTYHKPAYIEQYSLKTGKKMKEKEIGKVKDVVTPKSHLKLYDVEVMKRF*" /label="yycP CDS" gene complement(3788740..3789903) /gene="yycP" /locus_tag="BSU_40270" /old_locus_tag="BSU40270" /label="yycP gene" promotor_-10 complement(3788774..3788792) /Source="Nicolas_upshift_promotors" /id="U3171" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=531 /SigmaFactorBS="cggaaagaaaatgaaagaaaaagagattggGAAGGTAAAgga tgtcgtgaCGCCGAAGAGTCATTTGAAgctgtatgatgttgaggtgatgaagaggttt t" /listShort="yycQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3788782) /Source="Nicolas_upshifts" /id="U3171" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=531 /SigmaFactorBS="cggaaagaaaatgaaagaaaaagagattggGAAGGTAAAgga tgtcgtgaCGCCGAAGAGTCATTTGAAgctgtatgatgttgaggtgatgaagaggttt t" /listShort="yycQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3788804..3788812) /Source="Nicolas_upshift_promotors" /id="U3171" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp=1 /psig=1 /xcortree=531 /SigmaFactorBS="cggaaagaaaatgaaagaaaaagagattggGAAGGTAAAgga tgtcgtgaCGCCGAAGAGTCATTTGAAgctgtatgatgttgaggtgatgaagaggttt t" /listShort="yycQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3789914..3790651) /gene="yycO" /locus_tag="BSU_40280" /old_locus_tag="BSU40280" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16291680" /codon_start=1 /transl_table=11 /product="conserved exported protein" /protein_id="NP_391908.1" /db_xref="EnsemblGenomes-Gn:BSU40280" /db_xref="EnsemblGenomes-Tr:CAB16065" /db_xref="SubtiList:BG11468" /db_xref="UniProtKB/Swiss-Prot:Q45607" /translation="MKLKKRVSMFLVALTMCGGLFVTPAKAVKTTNYAEEIAALQPGT TPEEIMKSASQIAKQQHVKQDVILKQFYKEITADKAEGDRLAKESGMSIMGGSSGTKK LPTSAKGNIYYTNSYTAYYNHGHVGMYSAADKIVESVPSDGVRQIAYNARDVEDNSIV QTVSVSSSQKTAAADWAVSKVGDPYSFNFVNNRNTGHDGAKNCSKLLWSAFLLKAGID IDSNGGLGVYPRDITSSSYTTTIMTIY*" /label="yycO CDS" gene complement(3789914..3790651) /gene="yycO" /locus_tag="BSU_40280" /old_locus_tag="BSU40280" /label="yycO gene" promotor_-10 complement(3790693..3790711) /Source="Nicolas_upshift_promotors" /id="U3172" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.511488511488511" /psig="0.511488511488511" /xcortree=1227 /SigmaFactorBS="acgatttctaaaaattctgtaaataaCCTAGTTACtttcctt attttcCTAATATAATGTGGGTGAGgaaattacctttcctacactcacaagaaaagag g" /listShort="yycO, yycP, yycQ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3790699) /Source="Nicolas_upshifts" /id="U3172" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.511488511488511" /psig="0.511488511488511" /xcortree=1227 /SigmaFactorBS="acgatttctaaaaattctgtaaataaCCTAGTTACtttcctt attttcCTAATATAATGTGGGTGAGgaaattacctttcctacactcacaagaaaagag g" /listShort="yycO, yycP, yycQ" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3790725..3790733) /Source="Nicolas_upshift_promotors" /id="U3172" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.511488511488511" /psig="0.511488511488511" /xcortree=1227 /SigmaFactorBS="acgatttctaaaaattctgtaaataaCCTAGTTACtttcctt attttcCTAATATAATGTGGGTGAGgaaattacctttcctacactcacaagaaaagag g" /listShort="yycO, yycP, yycQ" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3790793..3791263) /gene="yycN" /locus_tag="BSU_40290" /old_locus_tag="BSU40290" /EC_number="2.3.1.-" /function="16.8: Protect" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 14635137, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative N-acetyltransferase" /protein_id="NP_391909.1" /db_xref="EnsemblGenomes-Gn:BSU40290" /db_xref="EnsemblGenomes-Tr:CAB16066" /db_xref="GOA:O32293" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="PDB:1ON0" /db_xref="PDB:1UFH" /db_xref="SubtiList:BG11467" /db_xref="UniProtKB/Swiss-Prot:O32293" /translation="MTIMLTPMQTEEFRSYLTYTTKHYAEEKVKAGTWLPEDAQLLSK QVFTDLLPRGLETPHHHLWSLKLNEKDIVGWLWIHAEPEHPQQEAFIYDFGLYEPYRG KGYAKQALAALDQAARSMGIRKLSLHVFAHNQTARKLYEQTGFQETDVVMSKKL*" /label="yycN CDS" gene complement(3790793..3791263) /gene="yycN" /locus_tag="BSU_40290" /old_locus_tag="BSU40290" /label="yycN gene" downshifts complement(3790806) /Source="Nicolas_upshifts" /id="D2084" /incds=0 /nref=1 /ntot=78 /MaxReadThrough="3.78599" /MaxDrop="2.94893" /score="8.04802973" /energy="-7.6" /TU="U3175" /idTUdmin="U3174" /TUdmin=0 /isTUend="TRUE" /label="downshifts" S_feature complement(3791264..3791334) /Source="Nicolas_S_feature" /locus_tag="new_4140150_4140220_c" /HighExp="S4, S5, S6, LoTm, S3, S7, S8, B36, BT, T5.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigEF" /TUshortPSig="0.997, 0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1549" promotor_-35 3791295..3791301 /Source="Nicolas_upshift_promotors" /id="U3173" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.551448551448551" /psig="0.995004995004995" /xcortree=3163 /SigmaFactorBS="attgtcatatcatctctccttcatatattgactagaggaTTT TACAtaaaatagaaagaGGTGTTACTATCAGAATAAGcaactgagattgataagtcac t" /listShort="rapG, phrG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3791315..3791334 /Source="Nicolas_upshift_promotors" /id="U3173" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.551448551448551" /psig="0.995004995004995" /xcortree=3163 /SigmaFactorBS="attgtcatatcatctctccttcatatattgactagaggaTTT TACAtaaaatagaaagaGGTGTTACTATCAGAATAAGcaactgagattgataagtcac t" /listShort="rapG, phrG" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-10 complement(3791316..3791335) /Source="Nicolas_upshift_promotors" /id="U3174" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.67032967032967" /psig="0.997002997002997" /xcortree=3164 /SigmaFactorBS="tgcgggtgcgatcttattcatgtgaaactcctttctcTAGTG ACTtatcaatctcagttGCTTATTCTGATAGTAACACctctttctattttatgtaaaa t" /listShort="S1549, yycN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3791316 /Source="Nicolas_upshifts" /id="U3173" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.551448551448551" /psig="0.995004995004995" /xcortree=3163 /SigmaFactorBS="attgtcatatcatctctccttcatatattgactagaggaTTT TACAtaaaatagaaagaGGTGTTACTATCAGAATAAGcaactgagattgataagtcac t" /listShort="rapG, phrG" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(3791334) /Source="Nicolas_upshifts" /id="U3174" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.67032967032967" /psig="0.997002997002997" /xcortree=3164 /SigmaFactorBS="tgcgggtgcgatcttattcatgtgaaactcctttctcTAGTG ACTtatcaatctcagttGCTTATTCTGATAGTAACACctctttctattttatgtaaaa t" /listShort="S1549, yycN" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3791336..3791611) /Source="Nicolas_S_feature" /locus_tag="new_4140222_4140497_c" /HighExp="S4, S5, S6, S7, S8, S3, B36, BT, LoTm, T5.0H" /AntisenseName="rapG" /AntisenseCor="-0.20647217228472101" /AntisenseRegPval="-3.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1550" promotor_-35 complement(3791350..3791357) /Source="Nicolas_upshift_promotors" /id="U3174" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.67032967032967" /psig="0.997002997002997" /xcortree=3164 /SigmaFactorBS="tgcgggtgcgatcttattcatgtgaaactcctttctcTAGTG ACTtatcaatctcagttGCTTATTCTGATAGTAACACctctttctattttatgtaaaa t" /listShort="S1549, yycN" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3791374..3792471 /gene="rapG" /locus_tag="BSU_40300" /old_locus_tag="BSU40300" /EC_number="3.1.-.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12950930, 16553878" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12950930, 16553878; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="response regulator aspartate phosphatase" /protein_id="NP_391910.1" /db_xref="EnsemblGenomes-Gn:BSU40300" /db_xref="EnsemblGenomes-Tr:CAB16067" /db_xref="GOA:O32294" /db_xref="InterPro:IPR011990" /db_xref="InterPro:IPR013026" /db_xref="InterPro:IPR019734" /db_xref="SubtiList:BG11466" /db_xref="UniProtKB/Swiss-Prot:O32294" /translation="MNKIAPAEIASMLNDWYLAIKKHEVEESSRLFEEVKPLLDDMEE DQEVLAYFSLLELRHKVLLHEARGQGFQHEEPSHMNATSDMLKYYFFLFEGMYEAYKN NYDIAIGLYKDAEQYLDNIPDPIEKAEFHLKVGKLYYKLGQNIVSLNHTRQAVKTFRE ETDYKKKLASALITMSGNFTEMSQFEEAEAYLDEAIRITSELEDHFFEAQLLHNFGLL HAQSGKSEEAVSKLEEALQNDEYARSAYYYHSAYLLIRELFKIKKKEQALSYYQDVKE KLTAEPNRICEAKIDILYAIYAEGGHAETFHLCKQHMDDLLSEKEYDSVRELSILAGE RYRELELYKEAAHFFYEALQIEELIKRTEVI*" /label="rapG CDS" gene 3791374..3792471 /gene="rapG" /locus_tag="BSU_40300" /old_locus_tag="BSU40300" /label="rapG gene" promotor_-10 complement(3791602..3791620) /Source="Nicolas_upshift_promotors" /id="U3175" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1127 /SigmaFactorBS="aggcctcatacatgccttcaaacagaaaaaaGTAATAtttca gcatgtcagACGTAGCATTCATATGAGAaggctcctcatgctgaaagccctgtcctct c" /listShort="S1550, S1549, yycN, yycO, yycP" /listLong="yycQ" /label="promotor_-10" upshifts complement(3791611) /Source="Nicolas_upshifts" /id="U3175" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1127 /SigmaFactorBS="aggcctcatacatgccttcaaacagaaaaaaGTAATAtttca gcatgtcagACGTAGCATTCATATGAGAaggctcctcatgctgaaagccctgtcctct c" /listShort="S1550, S1549, yycN, yycO, yycP" /listLong="yycQ" /label="upshifts" promotor_-35 complement(3791635..3791640) /Source="Nicolas_upshift_promotors" /id="U3175" /multdbtbs="-" /comp="M3" /sig="SigEF" /pcomp="0.998001998001998" /psig="0.998001998001998" /xcortree=1127 /SigmaFactorBS="aggcctcatacatgccttcaaacagaaaaaaGTAATAtttca gcatgtcagACGTAGCATTCATATGAGAaggctcctcatgctgaaagccctgtcctct c" /listShort="S1550, S1549, yycN, yycO, yycP" /listLong="yycQ" /label="promotor_-35" promotor_-35 3792195..3792203 /Source="Nicolas_upshift_promotors" /id="U3176" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=523 /SigmaFactorBS="acaggccttatcttattaccaagacgtGAAGGAAAAattgac tgctgAGCCGAATAGAATATGTGAggcaaaaatagacattttatatgccatttatgca g" /listShort="phrG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3792215..3792233 /Source="Nicolas_upshift_promotors" /id="U3176" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=523 /SigmaFactorBS="acaggccttatcttattaccaagacgtGAAGGAAAAattgac tgctgAGCCGAATAGAATATGTGAggcaaaaatagacattttatatgccatttatgca g" /listShort="phrG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3792228 /Source="Nicolas_upshifts" /id="U3176" /multdbtbs="SigH" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=523 /SigmaFactorBS="acaggccttatcttattaccaagacgtGAAGGAAAAattgac tgctgAGCCGAATAGAATATGTGAggcaaaaatagacattttatatgccatttatgca g" /listShort="phrG" /GFF_Attribute="listLong" /label="upshifts" CDS 3792472..3792588 /gene="phrG" /locus_tag="BSU_40310" /old_locus_tag="BSU40310" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:12950930, 16553878, 16816200" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12950930, 16553878, 16816200; Product type r: regulator" /codon_start=1 /transl_table=11 /product="secreted regulator of the activity of phosphatase RapG" /protein_id="NP_391911.1" /db_xref="EnsemblGenomes-Gn:BSU40310" /db_xref="EnsemblGenomes-Tr:CAB16068" /db_xref="InterPro:IPR030968" /db_xref="SubtiList:BG11465" /db_xref="UniProtKB/Swiss-Prot:O32295" /translation="MKRFLIGAGVAAVILSGWFIADHQTHSQEMKVAEKMIG*" /label="phrG CDS" gene 3792472..3792588 /gene="phrG" /locus_tag="BSU_40310" /old_locus_tag="BSU40310" /label="phrG gene" downshifts 3792577 /Source="Nicolas_upshifts" /id="D2085" /incds=0 /nref=39 /ntot=249 /MaxReadThrough="4.8963" /MaxDrop="7.30713" /score="31.0184314" /energy="-13.7" /TU="U3173,U3176" /idTUdmin="U3173" /TUdmin="-45" /isTUend="FALSE" /label="downshifts" CDS complement(3792825..3793715) /gene="argI" /locus_tag="BSU_40320" /old_locus_tag="BSU40320" /EC_number="3.5.3.1" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:104957, 4216455, 7540694, 10931887, 11418582, 12533460, 22720735, 23625224, 25355936" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 104957, 4216455, 7540694, 10931887, 11418582, 12533460, 22720735, 23625224, 25355936; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="arginase" /protein_id="NP_391912.1" /db_xref="EnsemblGenomes-Gn:BSU40320" /db_xref="EnsemblGenomes-Tr:CAB16069" /db_xref="GOA:P39138" /db_xref="InterPro:IPR006035" /db_xref="InterPro:IPR014033" /db_xref="InterPro:IPR020855" /db_xref="InterPro:IPR023696" /db_xref="SubtiList:BG10932" /db_xref="UniProtKB/Swiss-Prot:P39138" /translation="MDKTISVIGMPMDLGQARRGVDMGPSAIRYAHLIERLSDMGYTV EDLGDIPINREKIKNDEELKNLNSVLAGNEKLAQKVNKVIEEKKFPLVLGGDHSIAIG TLAGTAKHYDNLGVIWYDAHGDLNTLETSPSGNIHGMPLAVSLGIGHESLVNLEGYAP KIKPENVVIIGARSLDEGERKYIKESGMKVYTMHEIDRLGMTKVIEETLDYLSACDGV HLSLDLDGLDPNDAPGVGTPVVGGISYRESHLAMEMLYDAGIITSAEFVEVNPILDHK NKTGKTAVELVESLLGKKLL*" /label="argI CDS" gene complement(3792825..3793715) /gene="argI" /locus_tag="BSU_40320" /old_locus_tag="BSU40320" /label="argI gene" downshifts complement(3792831) /Source="Nicolas_upshifts" /id="D2086" /incds=0 /nref=1 /ntot=40 /MaxReadThrough="3.33097" /MaxDrop="3.38667" /score="2.36475602" /energy="-13.7" /TU="U3177" /idTUdmin="U3177" /TUdmin="-89" /isTUend="FALSE" /label="downshifts" downshifts complement(3792893) /Source="Nicolas_upshifts" /id="D2087" /incds=1 /nref=28 /ntot=201 /MaxReadThrough="5.16507" /MaxDrop="5.79932" /score="2.36475602" /energy="-13.7" /TU="U3177" /idTUdmin="U3177" /TUdmin="-151" /isTUend="FALSE" /label="downshifts" CDS complement(3793789..3795192) /gene="rocE" /locus_tag="BSU_40330" /old_locus_tag="BSU40330" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7540694, 10648515, 15849754, 16850406, 22720735" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7540694, 10648515, 15849754, 16850406, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="arginine/ornithine/gamma-aminobutyrate permease" /protein_id="NP_391913.1" /db_xref="EnsemblGenomes-Gn:BSU40330" /db_xref="EnsemblGenomes-Tr:CAB16070" /db_xref="GOA:P39137" /db_xref="InterPro:IPR002293" /db_xref="InterPro:IPR004840" /db_xref="InterPro:IPR004841" /db_xref="SubtiList:BG10933" /db_xref="UniProtKB/Swiss-Prot:P39137" /translation="MNTNQDNGNQLQRTMKSRHLFMISLGGVIGTGFFLGTGFTINQA GPLGAVLSYLVGGFIMFLTMLCLGELAVAFPVSGSFQTYATKFISPAFGFAFGWLYWL GWAVTCAIEFLSAGQLMQRWFPHIDVWIWCLVFAALMFILNAITTKAFAESEFWFSGI KILIILLFIILGGAAMFGLIDLKGGEQAPFLTHFYEDGLFPNGIKAMLITMITVNFAF QGTELIGVAAGESEDPEKTIPRSIKQTVWRTLVFFVLSIIVIAGMIPWKQAGVVESPF VAVFEQIGIPYAADIMNFVILIALLSVANSGLYASTRILYAMANEGQAFKALGKTNQR GVPMYSLIVTMAVACLSLLTKFAQAETVYMVLLSLAGMSAQVGWITISLSQIMFRRKY IREGGKIEDLKFKTPLYPVLPLIGLTLNTVVLISLAFDPEQRIALYCGVPFMIICYII YHVVIKKRQQANRQLEL*" /label="rocE CDS" gene complement(3793789..3795192) /gene="rocE" /locus_tag="BSU_40330" /old_locus_tag="BSU40330" /label="rocE gene" S_feature complement(3795193..3795414) /Source="Nicolas_S_feature" /locus_tag="new_4144079_4144300_c" /HighExp="Lbstat, S0, LPh, T1.30H, HPh, T2.0H, LPhT, BI, M0t90, M40t90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigL" /TUshortPSig="0.884" /TUlongSig="NA" /TUlongPSig="NA" /label="S1551" CDS complement(3795415..3796620) /gene="rocD" /locus_tag="BSU_40340" /old_locus_tag="BSU40340" /EC_number="2.6.1.13" /function="16.11: Scavenge (Catabolism)" /experiment="publication(s) with functional evidences, PMID:7540694, 9383188, 22720735, 23869754" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7540694, 9383188, 22720735, 23869754; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="ornithine aminotransferase" /protein_id="NP_391914.1" /db_xref="EnsemblGenomes-Gn:BSU40340" /db_xref="EnsemblGenomes-Tr:CAB16071" /db_xref="GOA:P38021" /db_xref="InterPro:IPR004636" /db_xref="InterPro:IPR005814" /db_xref="InterPro:IPR010164" /db_xref="InterPro:IPR015421" /db_xref="InterPro:IPR015422" /db_xref="InterPro:IPR015424" /db_xref="InterPro:IPR034757" /db_xref="SubtiList:BG10722" /db_xref="UniProtKB/Swiss-Prot:P38021" /translation="MTALSKSKEIIDQTSHYGANNYHPLPIVISEALGAWVKDPEGNE YMDMLSAYSAVNQGHRHPKIIQALKDQADKITLTSRAFHNDQLGPFYEKTAKLTGKEM ILPMNTGAEAVESAVKAARRWAYEVKGVADNQAEIIACVGNFHGRTMLAVSLSSEEEY KRGFGPMLPGIKLIPYGDVEALRQAITPNTAAFLFEPIQGEAGIVIPPEGFLQEAAAI CKEENVLFIADEIQTGLGRTGKTFACDWDGIVPDMYILGKALGGGVFPISCIAADREI LGVFNPGSHGSTFGGNPLACAVSIASLEVLEDEKLADRSLELGEYFKSELESIDSPVI KEVRGRGLFIGVELTEAARPYCERLKEEGLLCKETHDTVIRFAPPLIISKEDLDWAIE KIKHVLRNA*" /label="rocD CDS" gene complement(3795415..3796620) /gene="rocD" /locus_tag="BSU_40340" /old_locus_tag="BSU40340" /label="rocD gene" misc_feature complement(3796677..3796695) /Source="Nicolas_upshift_promotors" /id="U3177" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.884115884115884" /psig="0.884115884115884" /xcortree=390 /SigmaFactorBS="gcaccttgtcctcgaaaattgtagaaaacacacgaattcttg attTGGCACAGAACTTGCATTTatataaagggaaagcaggataacatgttgaaacaga a" /listShort="rocD, S1551, rocE, argI" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3796680) /Source="Nicolas_upshifts" /id="U3177" /multdbtbs="SigL" /comp="M18" /sig="SigL" /pcomp="0.884115884115884" /psig="0.884115884115884" /xcortree=390 /SigmaFactorBS="gcaccttgtcctcgaaaattgtagaaaacacacgaattcttg attTGGCACAGAACTTGCATTTatataaagggaaagcaggataacatgttgaaacaga a" /listShort="rocD, S1551, rocE, argI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3796790..3796795 /Source="Nicolas_upshift_promotors" /id="U3178" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.364635364635365" /psig="0.992007992007992" /xcortree=2367 /SigmaFactorBS="aaaatttcagcaagtgcaaaattctTTTGCAtatcctctccg tttTTTTATAAAATAGAAGCAATattaagaaaataattgagggaggttcatacagtgg t" /listShort="rocR" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3796810..3796829 /Source="Nicolas_upshift_promotors" /id="U3178" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.364635364635365" /psig="0.992007992007992" /xcortree=2367 /SigmaFactorBS="aaaatttcagcaagtgcaaaattctTTTGCAtatcctctccg tttTTTTATAAAATAGAAGCAATattaagaaaataattgagggaggttcatacagtgg t" /listShort="rocR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3796825 /Source="Nicolas_upshifts" /id="U3178" /multdbtbs="SigA" /comp="M19" /sig="SigA" /pcomp="0.364635364635365" /psig="0.992007992007992" /xcortree=2367 /SigmaFactorBS="aaaatttcagcaagtgcaaaattctTTTGCAtatcctctccg tttTTTTATAAAATAGAAGCAATattaagaaaataattgagggaggttcatacagtgg t" /listShort="rocR" /GFF_Attribute="listLong" /label="upshifts" CDS 3796861..3798246 /gene="rocR" /locus_tag="BSU_40350" /old_locus_tag="BSU40350" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9194709, 12533460, 12634342, 23869754" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9194709, 12533460, 12634342, 23869754; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (NtrC/NifA family)" /protein_id="NP_391915.1" /db_xref="EnsemblGenomes-Gn:BSU40350" /db_xref="EnsemblGenomes-Tr:CAB16072" /db_xref="GOA:P38022" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR002078" /db_xref="InterPro:IPR002197" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR009057" /db_xref="InterPro:IPR025662" /db_xref="InterPro:IPR025943" /db_xref="InterPro:IPR025944" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR035965" /db_xref="SubtiList:BG10723" /db_xref="UniProtKB/Swiss-Prot:P38022" /translation="MVKDSEFLTLVFQSILDEIDVGLHVVDEHGNTIVYNNKMMQIED MEKHDVLNKNLMDVFMFSKQQDSTLVQALQEGKTIKNVKQSYFNNKGQEITTINHTYP IVQDGKIRGAVEIAKDVTKLERLIRENMNKKGSTTYTFDSILGTSPAIQDVIENAKRA TRTSSSVLLAGETGTGKELFAQSIHNGSDRSGGPFISQNCAALPDSLVESILFGTKKG AFTGAVDQPGLFEQAHGGTLLLDEINSLNLSLQAKLLRALQERKIRRIGSTKDTPIDV RIIATMNEDPIDAIAGERMRKDLYYRLSVVTLIIPPLRERKEDILLLASEFIQKNNHL FQMNVEHISDDVKQFFLSYDWPGNIRELEHMIEGAMNFMTDEQTITASHLPYQYRMKI KPADIPEPETPRHQPAADLKEKMESFEKYVIENVLRKHGHNISKAAQELGISRQSLQY RLKKFSHSSNE*" /label="rocR CDS" gene 3796861..3798246 /gene="rocR" /locus_tag="BSU_40350" /old_locus_tag="BSU40350" /label="rocR gene" CDS complement(3798228..3798416) /gene="yyzO" /locus_tag="BSU_40359" /old_locus_tag="BSU40359" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17198402; Product type r: regulator" /pseudo /codon_start=1 /transl_table=11 /product="fragment of putative sensor protein" /db_xref="PSEUDO:CAX52717.1" /translation="MFDRFYKADPSRSRKYGGSGLGLAITKSIIDNHNGTIEVKSEIG RGTVFLIRLPAPDYSLDE*" /label="yyzO CDS" gene complement(3798228..3798416) /gene="yyzO" /locus_tag="BSU_40359" /old_locus_tag="BSU40359" /pseudo /label="yyzO gene" CDS complement(3798533..3798661) /locus_tag="BSU_40358" /old_locus_tag="BSU40358" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514013.1" /translation="MPGCFDMQKKLNRGHARSVEKGYIEYEEKYKMDVTRETANGS*" /label="hypothetical protein CDS" gene complement(3798533..3798661) /locus_tag="BSU_40358" /old_locus_tag="BSU40358" /label="gene" downshifts 3798585 /Source="Nicolas_upshifts" /id="D2088" /incds=0 /nref=1 /ntot=146 /MaxReadThrough="0.86899" /MaxDrop="2.90385" /score="20.2816165" /energy="-10.8" /TU="NA" /idTUdmin="U3178" /TUdmin=110 /isTUend="FALSE" /label="downshifts" CDS complement(3798681..3799883) /gene="htrC" /locus_tag="BSU_40360" /old_locus_tag="BSU40360" /EC_number="3.4.21.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10692364, 11133960, 16030236, 25384476" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10692364, 11133960, 16030236, 25384476; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="sporulation membrane serine protease" /protein_id="NP_391916.1" /db_xref="EnsemblGenomes-Gn:BSU40360" /db_xref="EnsemblGenomes-Tr:CAB16073" /db_xref="GOA:P39668" /db_xref="InterPro:IPR001478" /db_xref="InterPro:IPR001940" /db_xref="InterPro:IPR009003" /db_xref="InterPro:IPR036034" /db_xref="SubtiList:BG11054" /db_xref="UniProtKB/Swiss-Prot:P39668" /translation="MVDYEREEEHTTPEQPKRSKKGYFLSSLIGVIVGAVLMAFIMPY LSNEGLDTGALDQQQNNNGRESIRTVNVSVNNAVTKIVSNMSPAVVGVVNIQKSDIWG ESGEAGSGSGVIYKKNDHSAYVVTNHHVIEGASQIEISLKDGSRVSADLVGSDQLMDL AVLRVKSDKIKAVADFGNSDKVKSGEPVIAIGNPLGLEFAGSVTQGVISGTERAIPVD SNGDGQPDWNAEVLQTDAAINPGNSGGALLNMDGKVIGINSMKIAESAVEGIGLSIPS KLVIPVIEDLERYGKVKRPFLGIEMKSLSDIASYHWDETLKLPKNVTNGAVVMGVDAF SPAGKAGLKELDVITEFDGYKVNDIVDLRKRLYQKKVGDRVKVKFYRGGKEKSVDIKL SSADQLGS*" /label="htrC CDS" gene complement(3798681..3799883) /gene="htrC" /locus_tag="BSU_40360" /old_locus_tag="BSU40360" /label="htrC gene" downshifts complement(3798705) /Source="Nicolas_upshifts" /id="D2089" /incds=0 /nref=134 /ntot=253 /MaxReadThrough="2.3073" /MaxDrop="5.06813" /score="5.6507537" /energy="-15" /TU="NA" /idTUdmin="U3179" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3799915..3799926) /Source="Nicolas_upshift_promotors" /id="U3179" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=815 /SigmaFactorBS="gcgctgtataatttttctatgtaaatcaTGACTATtctagga gtttctaACCCACAATATAaccatattaacgttcttggaaaggatggaatatggtgga t" /listShort="htrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3799915) /Source="Nicolas_upshifts" /id="U3179" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=815 /SigmaFactorBS="gcgctgtataatttttctatgtaaatcaTGACTATtctagga gtttctaACCCACAATATAaccatattaacgttcttggaaaggatggaatatggtgga t" /listShort="htrC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3799941..3799947) /Source="Nicolas_upshift_promotors" /id="U3179" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.98901098901099" /psig="0.98901098901099" /xcortree=815 /SigmaFactorBS="gcgctgtataatttttctatgtaaatcaTGACTATtctagga gtttctaACCCACAATATAaccatattaacgttcttggaaaggatggaatatggtgga t" /listShort="htrC" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3799965..3800759) /gene="walJ" /locus_tag="BSU_40370" /old_locus_tag="BSU40370" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9829949, 16030236, 21169496; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_391917.2" /db_xref="EnsemblGenomes-Gn:BSU40370" /db_xref="EnsemblGenomes-Tr:CAB16074" /db_xref="GOA:C0SP91" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG11464" /db_xref="UniProtKB/Swiss-Prot:C0SP91" /translation="MSLQFSVLASGSTGNAFYLETEDHAFLVDAGLSGKAMDGLMAQI GRKLDDVDGIFVTHEHSDHIKGLGVVARKYKLPIYANEKTWKAMENQIGKIDTDQKFV FPMETVKSFGGLDVESFGVSHDAAEPMFYVFHYSGRKLALMTDTGYVSDRMKGIIRSA NVFVFESNHDVGMLQMGRYPWSIKRRILSDVGHVSNEDAALAMTDVIGDETSRIYLAH LSQDNNMKELARMSVQQTLASKGFVTGETFDLYDTDPKKATPLCAV*" /label="walJ CDS" gene complement(3799965..3800759) /gene="walJ" /locus_tag="BSU_40370" /old_locus_tag="BSU40370" /label="walJ gene" CDS complement(3800781..3801623) /gene="walI" /locus_tag="BSU_40380" /old_locus_tag="BSU40380" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16030236, 17307848, 17307850, 18408157, 21219466" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16030236, 17307848, 17307850, 18408157, 21219466; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of WalRK" /protein_id="NP_391918.1" /db_xref="EnsemblGenomes-Gn:BSU40380" /db_xref="EnsemblGenomes-Tr:CAB16075" /db_xref="GOA:Q45612" /db_xref="InterPro:IPR018604" /db_xref="PDB:2O3O" /db_xref="SubtiList:BG11463" /db_xref="UniProtKB/Swiss-Prot:Q45612" /translation="MEWNKTKSIFIVAFLILDIFLGYQFFQKWQATGKEYEVIKNDVE HDMKADHITYEGLNKEATEGYRITANQKSFSKEEIEALKDQKPLMDMPSDDHKVTSLK MKFANPIALSKKDIEDDAQALVSSKIQDGEKYKLWKVDKSKKEIIFFQTYEGHYIYQK TDNPSNMIGQVVLHLNGKNEVVSYDQTTLETFKQIQKESLITEMDAVELLYYQNQLKE YSTVKSCKFGYVAQYPLTSTQVLAPVWRITVEYEKKVNGEKKTVQEYFTVNALESTIL DTDQ*" /label="walI CDS" gene complement(3800781..3801623) /gene="walI" /locus_tag="BSU_40380" /old_locus_tag="BSU40380" /label="walI gene" CDS complement(3801610..3802977) /gene="walH" /locus_tag="Delta6_BSU_40390_SNPvariant" /old_locus_tag="BSU_40390" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:16030236, 16600972, 17307850, 26999783" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16030236, 16600972, 17307850, 26999783; Product type r: regulator" /codon_start=1 /transl_table=11 /product="regulator of WalRK(YycFG)" /protein_id="NP_391919.1" /db_xref="EnsemblGenomes-Gn:BSU40390" /db_xref="EnsemblGenomes-Tr:CAB16076" /db_xref="GOA:Q794W0" /db_xref="InterPro:IPR009996" /db_xref="PDB:2FGT" /db_xref="SubtiList:BG11462" /db_xref="UniProtKB/Swiss-Prot:Q794W0" /modified_by="User" /translation="MKRENIKTILLTVLVVISLVFTWGIWTFQPNFSEGSSSTESTVR VKHKIEKTTQKLSETVRPRDMFIHDDGAHYKVDDNALYEEIWSDLPHWDVKGIKDISD QYDKAGFKSWFYGIGGSEAKLDLQFSDTIPIDIFQTLFKWSNQSFEYSSFDHILIPFN ETKANKKIYLVSYSKQLILEVTVESANYRNIMNDLKNRQSNMPAFSLFSIGSKKEFLL PNKPLTMDKKEFVTESIKTNTFKQALFSDPSIVREDSNYTNRNVLTDGISRLDVNLSQ RQVQFQQRNLVQSTSYQTGELIKKSQKYLEDTGSWTDHYQFFNINDSQQLSFYIFMDQ IPVINSTAKPFGATSAITVQWANDDILSYKRPNYSLGTNPIKTSETELMGGSEVKMLL SKQTAYDTDKIDQIFLAYQLVSTSTNDDPLVELEPVWAMKVNGKIVPITKDLLRKEGA NSGVE*" /label="Delta6_BSU_40390_SNPvariant" gene complement(3801610..3802977) /gene="walH" /locus_tag="Delta6_BSU_40390_SNPvariant" /old_locus_tag="BSU_40390" /modified_by="User" /label="Delta6_BSU_40390_SNPvariant" Polymorphism join(3802204,3802206) /Source="geneious" /ID="SNP_BsDelta6_4151091_4151091" /Polymorphism_Type="SNP (transversion)" /note="SNP between marked nucleotides" /strain="Bacillus subtilis Delta6" /Length=1 /Amino_Acid_Change="N -> T" /CDS_Position=773 /Change="T -> G" /Codon_Change="AAC -> ACC" /Coverage=184 /locus_tag="BSU_40390" /Protein_Effect="Substitution" /Reference_Frequency="0.5%" /Reference_Nucleotides="T" /Variant_Nucleotides="G" /Variant_P_Value=0 /Variant_Raw_Frequency=183 /comment="Delta6_BSU_40390_SNPvariant" /modified_by="User" / /label="Polymorphism_Delta6" CDS complement(3802967..3804802) /gene="walK" /locus_tag="BSU_40400" /old_locus_tag="BSU40400" /function="16.12: Sense" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10878122, 12682299, 15015732, 15153768, 17307850, 17370266, 19019149, 22751669" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10878122, 12682299, 15015732, 15153768, 17307850, 17370266, 19019149, 22751669; Product type rc: receptor" /codon_start=1 /transl_table=11 /product="two-component sensor histidine kinase [YycG]" /protein_id="NP_391920.1" /db_xref="EnsemblGenomes-Gn:BSU40400" /db_xref="EnsemblGenomes-Tr:CAB16077" /db_xref="GOA:Q45614" /db_xref="InterPro:IPR000014" /db_xref="InterPro:IPR000700" /db_xref="InterPro:IPR001610" /db_xref="InterPro:IPR003594" /db_xref="InterPro:IPR003660" /db_xref="InterPro:IPR003661" /db_xref="InterPro:IPR004358" /db_xref="InterPro:IPR005467" /db_xref="InterPro:IPR035965" /db_xref="InterPro:IPR036097" /db_xref="InterPro:IPR036890" /db_xref="PDB:3SL2" /db_xref="SubtiList:BG11461" /db_xref="UniProtKB/Swiss-Prot:Q45614" /translation="MNKVGFFRSIQFKITLIYVLLIIIAMQIIGVYFVNQVEKSLISS YEQSLNQRIDNLSYYIEQEYKSDNDSTVIKDDVSRILNDFTKSDEVREISFVDKSYEV VGSSKPYGEEVAGKQTTDLIFKRIFSTKQSYLRKYYDPKSKIRVLISAKPVMTENQEV VGAIYVVASMEDVFNQMKTINTILASGTGLALVLTALLGIFLARTITHPLSDMRKQAM ELAKGNFSRKVKKYGHDEIGQLATTFNHLTRELEDAQAMTEGERRKLASVIAYMTDGV IATNRNGAIILLNSPALELLNVSRETALEMPITSLLGLQENYTFEDLVEQQDSMLLEI ERDDELTVLRVNFSVIQREHGKIDGLIAVIYDVTEQEKMDQERREFVANVSHELRTPL TTMRSYLEALAEGAWENKDIAPRFLMVTQNETERMIRLVNDLLQLSKFDSKDYQFNRE WIQIVRFMSLIIDRFEMTKEQHVEFIRNLPDRDLYVEIDQDKITQVLDNIISNALKYS PEGGHVTFSIDVNEEEELLYISVKDEGIGIPKKDVEKVFDRFYRVDKARTRKLGGTGL GLAIAKEMVQAHGGDIWADSIEGKGTTITFTLPYKEEQEDDWDEA*" /label="walK CDS" gene complement(3802967..3804802) /gene="walK" /locus_tag="BSU_40400" /old_locus_tag="BSU40400" /label="walK gene" CDS complement(3804810..3805517) /gene="walR" /locus_tag="BSU_40410" /old_locus_tag="BSU40410" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:10878122, 12682299, 15015732, 15153768, 17307850, 17370266, 18789936, 19019149, 21219466, 23199363, 24125693, 26102633, 28674376" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10878122, 12682299, 15015732, 15153768, 17307850, 17370266, 18789936, 19019149, 21219466, 23199363, 24125693, 26102633, 28674376; Product type r: regulator" /codon_start=1 /transl_table=11 /product="two-component response regulator [YycF]" /protein_id="NP_391921.1" /db_xref="EnsemblGenomes-Gn:BSU40410" /db_xref="EnsemblGenomes-Tr:CAB16078" /db_xref="GOA:P37478" /db_xref="InterPro:IPR001789" /db_xref="InterPro:IPR001867" /db_xref="InterPro:IPR011006" /db_xref="InterPro:IPR016032" /db_xref="InterPro:IPR036388" /db_xref="PDB:2D1V" /db_xref="PDB:2ZWM" /db_xref="PDB:3F6P" /db_xref="SubtiList:BG10001" /db_xref="UniProtKB/Swiss-Prot:P37478" /translation="MDKKILVVDDEKPIADILEFNLRKEGYEVHCAHDGNEAVEMVEE LQPDLILLDIMLPNKDGVEVCREVRKKYDMPIIMLTAKDSEIDKVIGLEIGADDYVTK PFSTRELLARVKANLRRQLTTAPAEEEPSSNEIHIGSLVIFPDAYVVSKRDETIELTH REFELLHYLAKHIGQVMTREHLLQTVWGYDYFGDVRTVDVTVRRLREKIEDNPSHPNW IVTRRGVGYYLRNPEQD*" /label="walR CDS" gene complement(3804810..3805517) /gene="walR" /locus_tag="BSU_40410" /old_locus_tag="BSU40410" /label="walR gene" S_feature complement(3805518..3805614) /Source="Nicolas_S_feature" /locus_tag="new_4154404_4154500_c" /HighExp="H2O2, G180, G150, Paraq, G135, Oxctl, dia0, LBGstat, dia5, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, Sig-" /TUshortPSig="1, 1, 0.11" /TUlongSig="SigA" /TUlongPSig="0.986" /label="S1552" promotor_-10 complement(3805602..3805621) /Source="Nicolas_upshift_promotors" /id="U3180" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.739260739260739" /psig=1 /xcortree=2526 /SigmaFactorBS="tgaaacatgtgttttttttctaaacctttattttTTTTatct tttgaccttaaACCGTTATAATAGACAAGGAcccattctttacatgggccataagtga t" /listShort="S1552, walR, walK, walH, yycI, yycJ, htrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3805614) /Source="Nicolas_upshifts" /id="U3180" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.739260739260739" /psig=1 /xcortree=2526 /SigmaFactorBS="tgaaacatgtgttttttttctaaacctttattttTTTTatct tttgaccttaaACCGTTATAATAGACAAGGAcccattctttacatgggccataagtga t" /listShort="S1552, walR, walK, walH, yycI, yycJ, htrC" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3805616..3805808) /Source="Nicolas_S_feature" /locus_tag="new_4154502_4154694_c" /HighExp="G180, Paraq, Oxctl, G135, G150, H2O2, T0.30H, BMM, Cold, B60" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, Sig-" /TUshortPSig="0.986, 1, 0.11" /TUlongSig="NA" /TUlongPSig="NA" /label="S1553" promotor_-35 complement(3805637..3805640) /Source="Nicolas_upshift_promotors" /id="U3180" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.739260739260739" /psig=1 /xcortree=2526 /SigmaFactorBS="tgaaacatgtgttttttttctaaacctttattttTTTTatct tttgaccttaaACCGTTATAATAGACAAGGAcccattctttacatgggccataagtga t" /listShort="S1552, walR, walK, walH, yycI, yycJ, htrC" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3805808) /Source="Nicolas_upshifts" /id="U3181" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.97902097902098" /psig="0.986013986013986" /xcortree=2753 /SigmaFactorBS="tttttcttttaggaaaaaggcaaacatgaggAGTGTTATAAT AGAAGAAAAagggagaaccggccctgcggccggttcaaagaagaagacgtcattgata a" /listShort="S1553" /listLong="S1552, walR, walK, walH, yycI, yycJ, htrC" /label="upshifts" misc_feature complement(3805818..3805837) /Source="Nicolas_upshift_promotors" /id="U3181" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.97902097902098" /psig="0.986013986013986" /xcortree=2753 /SigmaFactorBS="tttttcttttaggaaaaaggcaaacatgaggAGTGTTATAAT AGAAGAAAAagggagaaccggccctgcggccggttcaaagaagaagacgtcattgata a" /listShort="S1553" /listLong="S1552, walR, walK, walH, yycI, yycJ, htrC" /label="promotor_single_box" /note="Geneious type: promotor_single_box" downshifts complement(3805900) /Source="Nicolas_upshifts" /id="D2090" /incds=0 /nref=8 /ntot=83 /MaxReadThrough="5.21091" /MaxDrop="5.81799" /score="24.1725164" /energy="-10.6" /TU="U3183,U3184" /idTUdmin="U3181" /TUdmin="-264" /isTUend="FALSE" /label="downshifts" tRNA complement(3805901..3805973) /gene="trnY-Phe" /locus_tag="BSU_tRNA_1" /product="tRNA-Phe" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnY-Phe tRNA" gene complement(3805901..3805973) /gene="trnY-Phe" /locus_tag="BSU_tRNA_1" /label="trnY-Phe gene" tRNA complement(3806009..3806085) /gene="trnY-Asp" /locus_tag="BSU_tRNA_2" /product="tRNA-Asp" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnY-Asp tRNA" gene complement(3806009..3806085) /gene="trnY-Asp" /locus_tag="BSU_tRNA_2" /label="trnY-Asp gene" S_feature complement(3806086..3806166) /Source="Nicolas_S_feature" /locus_tag="new_4154972_4155052_c" /HighExp="Oxctl, Heat, BMM, Paraq, UNK1, H2O2, C30, MG 45, G180, MG 90" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="1, 0.11" /TUlongSig="NA" /TUlongPSig="NA" /label="S1554" tRNA complement(3806167..3806238) /gene="trnY-Glu" /locus_tag="BSU_tRNA_3" /product="tRNA-Glu" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnY-Glu tRNA" gene complement(3806167..3806238) /gene="trnY-Glu" /locus_tag="BSU_tRNA_3" /label="trnY-Glu gene" tRNA complement(3806248..3806323) /gene="trnY-Lys" /locus_tag="BSU_tRNA_4" /product="tRNA-Lys" /inference="profile:tRNAscan:1.23" /note="Evidence 2a: Function from experimental evidences in other organisms; Product type n: RNA" /function="16.2: Construct biomass (Anabolism)" /label="trnY-Lys tRNA" gene complement(3806248..3806323) /gene="trnY-Lys" /locus_tag="BSU_tRNA_4" /label="trnY-Lys gene" misc_feature 3806295..3806311 /Source="Nicolas_upshift_promotors" /id="U3182" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.652347652347652" /psig="0.0739260739260739" /xcortree=1705 /SigmaFactorBS="tggtgagccatgaaggactcgaaccttcgaccctctgattaa aagtcAGATGCTCTACCAACTGagctaatggctcttaaagatgtcggaatttctatag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3806308 /Source="Nicolas_upshifts" /id="U3182" /multdbtbs="-" /comp="M20" /sig="Sig-" /pcomp="0.652347652347652" /psig="0.0739260739260739" /xcortree=1705 /SigmaFactorBS="tggtgagccatgaaggactcgaaccttcgaccctctgattaa aagtcAGATGCTCTACCAACTGagctaatggctcttaaagatgtcggaatttctatag a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3806324..3806420) /Source="Nicolas_S_feature" /locus_tag="new_4155210_4155306_c" /HighExp="LBGstat, C30, UNK1, Oxctl, HPh, Heat, MG 150, BMM, Paraq, MG-0.2" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, Sig-" /TUshortPSig="1, 0.11" /TUlongSig="NA" /TUlongPSig="NA" /label="S1555" promotor_-10 complement(3806404..3806423) /Source="Nicolas_upshift_promotors" /id="U3183" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2627 /SigmaFactorBS="tctgagaaaaaaatatgaaaaaaaaccaaaaaagttATTGCC ACttctatttgttcgTGATATTATAAATCTCGTTGttacggaaactgcttcaatagag t" /listShort="S1555, trnY-Lys, trnY-Glu, S1554, trnY-Asp, trnY-Phe, S1553, S1552, walR, walK, walH, yycI, yycJ, htrC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3806420) /Source="Nicolas_upshifts" /id="U3183" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2627 /SigmaFactorBS="tctgagaaaaaaatatgaaaaaaaaccaaaaaagttATTGCC ACttctatttgttcgTGATATTATAAATCTCGTTGttacggaaactgcttcaatagag t" /listShort="S1555, trnY-Lys, trnY-Glu, S1554, trnY-Asp, trnY-Phe, S1553, S1552, walR, walK, walH, yycI, yycJ, htrC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3806437..3806444) /Source="Nicolas_upshift_promotors" /id="U3183" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.967032967032967" /psig=1 /xcortree=2627 /SigmaFactorBS="tctgagaaaaaaatatgaaaaaaaaccaaaaaagttATTGCC ACttctatttgttcgTGATATTATAAATCTCGTTGttacggaaactgcttcaatagag t" /listShort="S1555, trnY-Lys, trnY-Glu, S1554, trnY-Asp, trnY-Phe, S1553, S1552, walR, walK, walH, yycI, yycJ, htrC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_no_box complement(3806454..3806555) /Source="Nicolas_upshift_promotors" /id="U3184" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.587412587412587" /psig="0.10989010989011" /xcortree=285 /SigmaFactorBS="cgaactaaatagaatatgtctgcaagcccctatttaaggggc ttgtttttgtttgaaagccgcatataagttggtctgagaaaaaaatatgaaaaaaaac c" /listShort="S1555, trnY-Lys, trnY-Glu, S1554, trnY-Asp, trnY-Phe, S1553, S1552, walR, walK, walH, yycI, yycJ, htrC" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(3806494) /Source="Nicolas_upshifts" /id="U3184" /multdbtbs="-" /comp="M21" /sig="Sig-" /pcomp="0.587412587412587" /psig="0.10989010989011" /xcortree=285 /SigmaFactorBS="cgaactaaatagaatatgtctgcaagcccctatttaaggggc ttgtttttgtttgaaagccgcatataagttggtctgagaaaaaaatatgaaaaaaaac c" /listShort="S1555, trnY-Lys, trnY-Glu, S1554, trnY-Asp, trnY-Phe, S1553, S1552, walR, walK, walH, yycI, yycJ, htrC" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3806548..3807840) /gene="purA" /locus_tag="BSU_40420" /old_locus_tag="BSU40420" /EC_number="6.3.4.4" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:1312531, 10368157, 16163456, 21424839" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1312531, 10368157, 16163456, 21424839; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="adenylosuccinate synthetase" /protein_id="NP_391922.1" /db_xref="EnsemblGenomes-Gn:BSU40420" /db_xref="EnsemblGenomes-Tr:CAB16079" /db_xref="GOA:P29726" /db_xref="InterPro:IPR001114" /db_xref="InterPro:IPR018220" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR033128" /db_xref="SubtiList:BG10002" /db_xref="UniProtKB/Swiss-Prot:P29726" /translation="MSSVVVVGTQWGDEGKGKITDFLSENAEVIARYQGGNNAGHTIK FDGITYKLHLIPSGIFYKDKTCVIGNGMVVDPKALVTELAYLHERNVSTDNLRISNRA HVILPYHLKLDEVEEERKGANKIGTTKKGIGPAYMDKAARIGIRIADLLDRDAFAEKL ERNLEEKNRLLEKMYETEGFKLEDILDEYYEYGQQIKKYVCDTSVVLNDALDEGRRVL FEGAQGVMLDIDQGTYPFVTSSNPVAGGVTIGSGVGPTKIKHVVGVSKAYTTRVGDGP FPTELKDEIGDQIREVGREYGTTTGRPRRVGWFDSVVVRHARRVSGITDLSLNSIDVL AGIETLKICVAYRYKGEIIEEFPASLKALAECEPVYEEMPGWTEDITGAKSLSELPEN ARHYLERVSQLTGIPLSIFSVGPDRSQTNVLRSVYRAN*" /label="purA CDS" gene complement(3806548..3807840) /gene="purA" /locus_tag="BSU_40420" /old_locus_tag="BSU40420" /label="purA gene" downshifts complement(3806559) /Source="Nicolas_upshifts" /id="D2091" /incds=0 /nref=200 /ntot=241 /MaxReadThrough="2.03104" /MaxDrop="6.53551" /score="13.9967927" /energy="-10.5" /TU="NA" /idTUdmin="U3185" /TUdmin=1 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3807880..3807899) /Source="Nicolas_upshift_promotors" /id="U3185" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=2426 /SigmaFactorBS="acgaatatagatttacaataaattaatgttcggatttacAAT TGACTttctgtttcttcacTGATAAACTTGATTTGTTTGaatagaatcgttttgaaag g" /listShort="purA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3807900) /Source="Nicolas_upshifts" /id="U3185" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=2426 /SigmaFactorBS="acgaatatagatttacaataaattaatgttcggatttacAAT TGACTttctgtttcttcacTGATAAACTTGATTTGTTTGaatagaatcgttttgaaag g" /listShort="purA" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3807914..3807921) /Source="Nicolas_upshift_promotors" /id="U3185" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.932067932067932" /psig=1 /xcortree=2426 /SigmaFactorBS="acgaatatagatttacaataaattaatgttcggatttacAAT TGACTttctgtttcttcacTGATAAACTTGATTTGTTTGaatagaatcgttttgaaag g" /listShort="purA" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3808046..3808465) /gene="yycE" /locus_tag="BSU_40430" /old_locus_tag="BSU40430" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 16731985" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391923.1" /db_xref="EnsemblGenomes-Gn:BSU40430" /db_xref="EnsemblGenomes-Tr:CAB16080" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="PDB:1TWU" /db_xref="SubtiList:BG10003" /db_xref="UniProtKB/Swiss-Prot:P37479" /translation="MGKRFSSFQAAQIRIARPTGQLDEIIRFYEEGLCLKRIGEFSQH NGYDGVMFGLPHADYHLEFTQYEGGSTAPVPHPDSLLVFYVPNAVELAAITSKLKHMG YQEVESENPYWSNGGVTIEDPDGWRIVFMNSKGISGK*" /label="yycE CDS" gene complement(3808046..3808465) /gene="yycE" /locus_tag="BSU_40430" /old_locus_tag="BSU40430" /label="yycE gene" promotor_-10 complement(3808463..3808474) /Source="Nicolas_upshift_promotors" /id="U3186" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=870 /SigmaFactorBS="acgttcgctcagcggatgaaaaattgaaagcgttttaatAAA ATGGtgcaaaaaggagatGGTAACAATATGggaaaacgtttttcgtcttttcaagcag c" /listShort="yycE" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3808474) /Source="Nicolas_upshifts" /id="U3186" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=870 /SigmaFactorBS="acgttcgctcagcggatgaaaaattgaaagcgttttaatAAA ATGGtgcaaaaaggagatGGTAACAATATGggaaaacgtttttcgtcttttcaagcag c" /listShort="yycE" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3808489..3808495) /Source="Nicolas_upshift_promotors" /id="U3186" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.997002997002997" /psig="0.997002997002997" /xcortree=870 /SigmaFactorBS="acgttcgctcagcggatgaaaaattgaaagcgttttaatAAA ATGGtgcaaaaaggagatGGTAACAATATGggaaaacgtttttcgtcttttcaagcag c" /listShort="yycE" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3808586..3809950) /gene="dnaC" /locus_tag="BSU_40440" /old_locus_tag="BSU40440" /EC_number="3.6.4.12" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:7711902, 10844689, 12682299, 12718886, 16002087, 19744498, 23563155, 25713353" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7711902, 10844689, 12682299, 12718886, 16002087, 19744498, 23563155, 25713353; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="replicative DNA helicase" /protein_id="NP_391924.2" /db_xref="EnsemblGenomes-Gn:BSU40440" /db_xref="EnsemblGenomes-Tr:CAB16081" /db_xref="GOA:P37469" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR007692" /db_xref="InterPro:IPR007693" /db_xref="InterPro:IPR007694" /db_xref="InterPro:IPR016136" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR036185" /db_xref="SubtiList:BG10004" /db_xref="UniProtKB/Swiss-Prot:P37469" /translation="MTDLLNDRLPPQNIEAEQAVLGAIFLQPSALTLASEVLIPDDFY RMSHQKIYNAMLVLGDRGEPVDLVTVTSELANTDLLEEVGGISYLTDIANSVPTAANI EYYAKIVEEKSILRRLIRTATTIAQDGYTREDEVEDLLSEAEKTIMEVAQRKNTSAFQ NIKDVLVQTYDNIEQLHNRKGDITGIPTGFTELDRMTAGFQRNDLIIVAARPSVGKTA FALNIAQNVATKTDESVAIFSLEMGAEQLVMRMLCAEGNINAQNLRTGNLTEEDWGKL TMAMGSLSNSGIYIDDTPGIRVSEIRAKCRRLKQESGLGMILIDYLQLIQGSGRSKDN RQQEVSEISRELKSIARELQVPVIALSQLSRGVEQRQDKRPMMSDIRESGSIEQDADI VAFLYRDDYYDKETENKNIIEIIIAKQRNGPVGTVSLAFVKEYNKFVNLERRFDDAGV PPGA*" /label="dnaC CDS" gene complement(3808586..3809950) /gene="dnaC" /locus_tag="BSU_40440" /old_locus_tag="BSU40440" /label="dnaC gene" downshifts complement(3808606) /Source="Nicolas_upshifts" /id="D2092" /incds=0 /nref=3 /ntot=107 /MaxReadThrough="1.37092" /MaxDrop="3.96365" /score="31.6981667" /energy="-12.6" /TU="NA" /idTUdmin="U3187" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(3808650) /Source="Nicolas_upshifts" /id="D2093" /incds=1 /nref=9 /ntot=190 /MaxReadThrough="3.89737" /MaxDrop="3.21735" /score="31.6981667" /energy="-12.6" /TU="U3187" /idTUdmin="U3190" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3809981..3810000) /Source="Nicolas_upshift_promotors" /id="U3187" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.573426573426573" /psig=1 /xcortree=2596 /SigmaFactorBS="tctgctaactgaaaaaaacaggaaacagacaatttttcTATt ttttttctgtagaAATGGTAGAATGGAGGTTGGagattttttaatgagaggacggtgc t" /listShort="dnaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3809995) /Source="Nicolas_upshifts" /id="U3187" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.573426573426573" /psig=1 /xcortree=2596 /SigmaFactorBS="tctgctaactgaaaaaaacaggaaacagacaatttttcTATt ttttttctgtagaAATGGTAGAATGGAGGTTGGagattttttaatgagaggacggtgc t" /listShort="dnaC" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3810015..3810017) /Source="Nicolas_upshift_promotors" /id="U3187" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.573426573426573" /psig=1 /xcortree=2596 /SigmaFactorBS="tctgctaactgaaaaaaacaggaaacagacaatttttcTATt ttttttctgtagaAATGGTAGAATGGAGGTTGGagattttttaatgagaggacggtgc t" /listShort="dnaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3810062..3810068 /Source="Nicolas_upshift_promotors" /id="U3188" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=184 /SigmaFactorBS="tgtctgtttcctgtttttttcagttagcagattggatCGTTT CGgacagtaacaaggcGGGAAAAATGCAATAAAACataagggaggaatgaaagatgat a" /listShort="yycD, S1556" /listLong="yycC, S1558, yycB" /label="promotor_-35" promotor_-10 3810083..3810101 /Source="Nicolas_upshift_promotors" /id="U3188" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=184 /SigmaFactorBS="tgtctgtttcctgtttttttcagttagcagattggatCGTTT CGgacagtaacaaggcGGGAAAAATGCAATAAAACataagggaggaatgaaagatgat a" /listShort="yycD, S1556" /listLong="yycC, S1558, yycB" /label="promotor_-10" upshifts 3810085 /Source="Nicolas_upshifts" /id="U3188" /multdbtbs="SigB" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=184 /SigmaFactorBS="tgtctgtttcctgtttttttcagttagcagattggatCGTTT CGgacagtaacaaggcGGGAAAAATGCAATAAAACataagggaggaatgaaagatgat a" /listShort="yycD, S1556" /listLong="yycC, S1558, yycB" /label="upshifts" CDS 3810120..3810320 /gene="yycD" /locus_tag="BSU_40450" /old_locus_tag="BSU40450" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11717295" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391925.1" /db_xref="EnsemblGenomes-Gn:BSU40450" /db_xref="EnsemblGenomes-Tr:CAB16082" /db_xref="InterPro:IPR018691" /db_xref="InterPro:IPR020086" /db_xref="SubtiList:BG10005" /db_xref="UniProtKB/Swiss-Prot:P37480" /translation="MIKKYAITPNVDADGWFIEVENVAPTALYTSKDAAIEKAKQVAK ENSPSKLVIYDQFKNVEEEHSF*" /label="yycD CDS" gene 3810120..3810320 /gene="yycD" /locus_tag="BSU_40450" /old_locus_tag="BSU40450" /label="yycD gene" downshifts 3810290 /Source="Nicolas_upshifts" /id="D2094" /incds=0 /nref=15 /ntot=43 /MaxReadThrough="4.45045" /MaxDrop="5.68737" /score="12.3008592" /energy="-9.5" /TU="U3188" /idTUdmin="U3188" /TUdmin="-352" /isTUend="FALSE" /label="downshifts" S_feature 3810335..3810656 /Source="Nicolas_S_feature" /locus_tag="new_4159220_4159541" /HighExp="Etha, C30, Salt, S6, S8, M9-stat, S7, Oxctl, Paraq, Heat" /AntisenseName="yyzB" /AntisenseCor="0.309580857935493" /AntisenseRegPval="-6.7" /CDS_PredictionProba="NA" /TUshortSig="SigB" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1556" CDS complement(3810368..3810571) /gene="yyzB" /locus_tag="BSU_40460" /old_locus_tag="BSU40460" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391926.1" /db_xref="EnsemblGenomes-Gn:BSU40460" /db_xref="EnsemblGenomes-Tr:CAB16083" /db_xref="SubtiList:BG14171" /db_xref="UniProtKB/Swiss-Prot:O32296" /translation="MHAPLSLLKQMLKEHQIDTEKAVTFEEYIAMRLKLQELMGKFAS IGEWDLYQKAADLMMHIGIQWMK*" /label="yyzB CDS" gene complement(3810368..3810571) /gene="yyzB" /locus_tag="BSU_40460" /old_locus_tag="BSU40460" /label="yyzB gene" S_feature complement(3810572..3810872) /Source="Nicolas_S_feature" /locus_tag="new_4159457_4159757_c" /HighExp="S6, S8, S7, S5, S4, BT, B36, T5.0H, S3, C30" /AntisenseName="yycC" /AntisenseCor="-0.77379453158709499" /AntisenseRegPval="-54.1" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.049" /TUlongSig="NA" /TUlongPSig="NA" /label="S1557" promotor_-35 3810637..3810640 /Source="Nicolas_upshift_promotors" /id="U3189" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.912087912087912" /psig=1 /xcortree=2150 /SigmaFactorBS="cggtcattttccgattgctctattcctttgtgacatcttCTT AcatttcacatctgaTTCTTGTACAATGGACAGAAgagaggagggatcttttgtgaga c" /listShort="yycC, S1558, yycB, yycA" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3810655..3810674 /Source="Nicolas_upshift_promotors" /id="U3189" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.912087912087912" /psig=1 /xcortree=2150 /SigmaFactorBS="cggtcattttccgattgctctattcctttgtgacatcttCTT AcatttcacatctgaTTCTTGTACAATGGACAGAAgagaggagggatcttttgtgaga c" /listShort="yycC, S1558, yycB, yycA" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3810658 /Source="Nicolas_upshifts" /id="U3189" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.912087912087912" /psig=1 /xcortree=2150 /SigmaFactorBS="cggtcattttccgattgctctattcctttgtgacatcttCTT AcatttcacatctgaTTCTTGTACAATGGACAGAAgagaggagggatcttttgtgaga c" /listShort="yycC, S1558, yycB, yycA" /GFF_Attribute="listLong" /label="upshifts" CDS 3810692..3810832 /gene="yycC" /locus_tag="BSU_40470" /old_locus_tag="BSU40470" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 28546427" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391927.1" /db_xref="EnsemblGenomes-Gn:BSU40470" /db_xref="EnsemblGenomes-Tr:CAB16084" /db_xref="InterPro:IPR025550" /db_xref="SubtiList:BG10006" /db_xref="UniProtKB/Swiss-Prot:P37481" /translation="MRPLQISAETAQKLAESLNLPLEQIMHMPQHILLAKMAELQKED KS*" /label="yycC CDS" gene 3810692..3810832 /gene="yycC" /locus_tag="BSU_40470" /old_locus_tag="BSU40470" /label="yycC gene" S_feature 3810833..3810904 /Source="Nicolas_S_feature" /locus_tag="new_4159718_4159789" /HighExp="Sw, LoTm, Gly, BC, HiOs, B60, S0, T-5.40H, LBGstat, Cold" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigB" /TUlongPSig=1 /label="S1558" upshifts complement(3810880) /Source="Nicolas_upshifts" /id="U3190" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.935064935064935" /psig="0.048951048951049" /xcortree=1271 /SigmaFactorBS="aaatgattggatttttttattatgtggatgtGGCAAagcagt tACTCCTCTTTTCTAAcatatacatgatattatcccgaaacaggtaagcaagtatgtg a" /listShort="S1557, yyzB, dnaC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3810883..3810897) /Source="Nicolas_upshift_promotors" /id="U3190" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.935064935064935" /psig="0.048951048951049" /xcortree=1271 /SigmaFactorBS="aaatgattggatttttttattatgtggatgtGGCAAagcagt tACTCCTCTTTTCTAAcatatacatgatattatcccgaaacaggtaagcaagtatgtg a" /listShort="S1557, yyzB, dnaC" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3810905..3810909) /Source="Nicolas_upshift_promotors" /id="U3190" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.935064935064935" /psig="0.048951048951049" /xcortree=1271 /SigmaFactorBS="aaatgattggatttttttattatgtggatgtGGCAAagcagt tACTCCTCTTTTCTAAcatatacatgatattatcccgaaacaggtaagcaagtatgtg a" /listShort="S1557, yyzB, dnaC" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3810905..3812113 /gene="yycB" /locus_tag="BSU_40480" /old_locus_tag="BSU40480" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 25790494; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative anion ABC transporter (permease)" /protein_id="NP_391928.1" /db_xref="EnsemblGenomes-Gn:BSU40480" /db_xref="EnsemblGenomes-Tr:CAB16085" /db_xref="GOA:P37482" /db_xref="InterPro:IPR004747" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10007" /db_xref="UniProtKB/Swiss-Prot:P37482" /translation="MPHPHNKKIQSFWLITGIIFIAFNLRPAITSVGPVISSIRAELH MSNGAAGFLTALPLLSFAVLSPLAPKLGQRLGNERTLWLGLVILLIGVLTRSTGYTAA LFFGTALIGVGIAIGNVLLPSLIKHKYPEKPGIMISLYTTSMNIFAALASGVSVPLAT QMNGGWKQAFLLWGGLALLALLIWIPQLRHRDTANQTMKLQSSSIWASKMAWYVTIFM GLQSFLFYSSIAWFPEILRSHGIDTATAGWMVSLMQFASLPSTFLTPVLADRVKQQRG IVAALASVYLIGLCGLLAGGSHTLLAIWMIIIGIGQGSSISLALTLIGLRSENAQQAA ALSGMSQSFGYLLAAVGPIFVGYLFDQTHSWTMPIVLLIAALIVMGAAGQGAGRDRYI FQSEKQRNSA*" /label="yycB CDS" gene 3810905..3812113 /gene="yycB" /locus_tag="BSU_40480" /old_locus_tag="BSU40480" /label="yycB gene" downshifts 3812094 /Source="Nicolas_upshifts" /id="D2095" /incds=0 /nref=148 /ntot=242 /MaxReadThrough="3.65611" /MaxDrop="4.91246" /score="26.443484" /energy="-10.1" /TU="U3189" /idTUdmin="U3189" /TUdmin="-484" /isTUend="FALSE" /label="downshifts" CDS 3812218..3814275 /gene="yycA" /locus_tag="BSU_40490" /old_locus_tag="BSU40490" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 20512483; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative glycosyl transferase" /protein_id="NP_391929.2" /db_xref="EnsemblGenomes-Gn:BSU40490" /db_xref="EnsemblGenomes-Tr:CAB16086" /db_xref="GOA:P37483" /db_xref="SubtiList:BG10008" /db_xref="UniProtKB/Swiss-Prot:P37483" /translation="MKTKRFDAALILILLAAAFLNTYHIWQDDTANQYYLAAVKSMTQ SFHNFFYASFDPSGFVTVDKPPVVLWIQTIFALIFGVHTWSVIIPQALAGVGSVFLLY RMVKPTFGVGAARIAALVMALTPIAVAVSRTNNIDSMLVFTLLLGSTCLLRAVKQGKL VWLLTAFALIGLAFNMKMMQAFMVLPAFVLFYLIASRVSLKKKIGSLLLSLVLLTGLS LSWAIAVDSASSSSRPYVGSSQTNSVLELAFGYNGTERLFGQTTGLAKGDMNAAGGGN MQNQDNMQAPNGNGSSFSQNGNQSFGNHSQAPQPPNGQTGALNGGGGTPPTGGNGPGN GGPGGGGGKSVNMFGTGDPGPLRLFQSALSGQISWMLPFSLIGLLGAIISWYRDRRGH AAKMKETLFWAAWLVPVAGFFSIAGFFHQYYLIMLAPPIAALSGIGWYTMHRLYKNNK DWSSYLLPAAVLITAVFQVYILSAYTSQIGSVWMYVLGLLGLGITLALLMLKRSHPFS KLLTIISLCVLLLTPVYWSATPLLYGGNSVLPESGPQLKGSANGGNMFSSEVDSGLLS YLRKHNTGEEYLFATLTTVTAAPYIIYENESVMAMGGFNGTDPILTVSELKKLIKEGK VKYFLLSENNSGNSELVSWIKKNGKEITSDEYSGSSSSTNSVQGMRRGPGGESQQTLY LVE*" /label="yycA CDS" gene 3812218..3814275 /gene="yycA" /locus_tag="BSU_40490" /old_locus_tag="BSU40490" /label="yycA gene" downshifts 3814140 /Source="Nicolas_upshifts" /id="D2096" /incds=1 /nref=43 /ntot=203 /MaxReadThrough="1.96363" /MaxDrop="3.65354" /score="19.8733078" /energy="-16.6" /TU="NA" /idTUdmin="U3189" /TUdmin=1562 /isTUend="FALSE" /label="downshifts" CDS complement(3814312..3814761) /gene="rplI" /locus_tag="BSU_40500" /old_locus_tag="BSU40500" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9000630, 9588797, 11399077, 12682299, 14586115, 23002217" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9000630, 9588797, 11399077, 12682299, 14586115, 23002217; Product type f : factor" /codon_start=1 /transl_table=11 /product="ribosomal protein L9" /protein_id="NP_391930.1" /db_xref="EnsemblGenomes-Gn:BSU40500" /db_xref="EnsemblGenomes-Tr:CAB16087" /db_xref="GOA:P37437" /db_xref="InterPro:IPR000244" /db_xref="InterPro:IPR009027" /db_xref="InterPro:IPR020069" /db_xref="InterPro:IPR020070" /db_xref="InterPro:IPR020594" /db_xref="InterPro:IPR036791" /db_xref="InterPro:IPR036935" /db_xref="SubtiList:BG10009" /db_xref="UniProtKB/Swiss-Prot:P37437" /translation="MKVIFLQDVKGKGKKGEVKNVADGYAHNFLIKKGLAVEANASNI SALNGQKQKEKKEAIAELEQAKSLKETLEKLTVELSAKSGEGGRLFGSVTSKQITEQL QKDHNIKVDKRKLELPDGIRALGYTNVPVKLHPEVQAVLKVHVKEEA*" /label="rplI CDS" gene complement(3814312..3814761) /gene="rplI" /locus_tag="BSU_40500" /old_locus_tag="BSU40500" /label="rplI gene" downshifts complement(3814326) /Source="Nicolas_upshifts" /id="D2097" /incds=0 /nref=231 /ntot=266 /MaxReadThrough="2.69721" /MaxDrop="6.57383" /score="44.1169256" /energy="-16.6" /TU="NA" /idTUdmin="U3191" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3814758..3816737) /gene="gdpP" /locus_tag="BSU_40510" /old_locus_tag="BSU40510" /EC_number="3.1.4.-" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:19901023, 19553197, 21257773, 21566650, 24465894, 24680501, 25616256, 26240071, 27150552, 28069645" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 19901023, 19553197, 21257773, 21566650, 24465894, 24680501, 25616256, 26240071, 27150552, 28069645; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="phosphodiesterase acting on cyclic dinucleotides" /protein_id="NP_391931.1" /db_xref="EnsemblGenomes-Gn:BSU40510" /db_xref="EnsemblGenomes-Tr:CAB16088" /db_xref="GOA:P37484" /db_xref="InterPro:IPR000160" /db_xref="InterPro:IPR001667" /db_xref="InterPro:IPR003156" /db_xref="InterPro:IPR014528" /db_xref="SubtiList:BG10010" /db_xref="UniProtKB/Swiss-Prot:P37484" /translation="MPSFYEKPLFRYPIYALIALSIITILISFYFNWILGTVEVLLLA VILFFIKRADSLIRQEIDAYISTLSYRLKKVGEEALMEMPIGIMLFNDQYYIEWANPF LSSCFNESTLVGRSLYDTCESVVPLIKQEVESETVTLNDRKFRVVIKRDERLLYFFDV TEQIQIEKLYENERTVLAYIFLDNYDDVTQGLDDQTRSTMNSQVTSLLNAWAQEYGIF LKRTSSERFIAVLNEHILTELENSKFSILDEVREKTSFDGVALTLSVGVGASVSSLKE LGDLAQSSLDLALGRGGDQVAIKLPNGKVKFYGGKTNPMEKRTRVRARVISHALKEIV TESSNVIIMGHKFPDMDSIGAAIGILKVAQANNKDGFIVIDPNQIGSSVQRLIGEIKK YEELWSRFITPEEAMEISNDDTLLVIVDTHKPSLVMEERLVNKIEHIVVIDHHRRGEE FIRDPLLVYMEPYASSTAELVTELLEYQPKRLKINMIEATALLAGIIVDTKSFSLRTG SRTFDAASYLRAKGADTVLVQKFLKETVDSYIKRAKLIQHTVLYKDNIAIASLPENEE EYFDQVLIAQAADSLLSMSEVEASFAVARRDEQTVCISARSLGEVNVQIIMEALEGGG HLTNAATQLSGISVSEALERLKHAIDEYFEGGVQR*" /label="gdpP CDS" gene complement(3814758..3816737) /gene="gdpP" /locus_tag="BSU_40510" /old_locus_tag="BSU40510" /label="gdpP gene" misc_feature complement(3815239..3815258) /Source="Nicolas_upshift_promotors" /id="U3191" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.454545454545455" /psig="0.997002997002997" /xcortree=2666 /SigmaFactorBS="cgaagcgcttaaaaatcaatatgattgaagcaacagccctat taGCTGGTATAATAGTGGATACaaagagcttttctctccgcacgggctcgcggacttt c" /listShort="rplI" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3815242) /Source="Nicolas_upshifts" /id="U3191" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.454545454545455" /psig="0.997002997002997" /xcortree=2666 /SigmaFactorBS="cgaagcgcttaaaaatcaatatgattgaagcaacagccctat taGCTGGTATAATAGTGGATACaaagagcttttctctccgcacgggctcgcggacttt c" /listShort="rplI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3815655..3815662 /Source="Nicolas_upshift_promotors" /id="U3192" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2818 /SigmaFactorBS="acgataaaaccatctttgttatttgcctgagccacCTTTAAA AtcccgatcgctgcGCCGATAGAATCCATGTCGgggaatttatgccccatgataatca c" /listShort="S1559" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3815676..3815694 /Source="Nicolas_upshift_promotors" /id="U3192" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2818 /SigmaFactorBS="acgataaaaccatctttgttatttgcctgagccacCTTTAAA AtcccgatcgctgcGCCGATAGAATCCATGTCGgggaatttatgccccatgataatca c" /listShort="S1559" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3815680..3816346 /Source="Nicolas_S_feature" /locus_tag="new_4164565_4165231" /HighExp="LBGstat, C30, Cold, GM 10, GM 25, GM 15, GM-0.1, GM 45, GM 120, GM 90" /AntisenseName="yybT" /AntisenseCor="0.145393098609886" /AntisenseRegPval="-1.8" /CDS_PredictionProba="NA" /TUshortSig="SigD" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1559" upshifts 3815680 /Source="Nicolas_upshifts" /id="U3192" /multdbtbs="-" /comp="M10" /sig="SigD" /pcomp=1 /psig=1 /xcortree=2818 /SigmaFactorBS="acgataaaaccatctttgttatttgcctgagccacCTTTAAA AtcccgatcgctgcGCCGATAGAATCCATGTCGgggaatttatgccccatgataatca c" /listShort="S1559" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3816774..3817703) /gene="yybS" /locus_tag="BSU_40520" /old_locus_tag="BSU40520" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 22956758; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391932.1" /db_xref="EnsemblGenomes-Gn:BSU40520" /db_xref="EnsemblGenomes-Tr:CAB16089" /db_xref="InterPro:IPR018710" /db_xref="SubtiList:BG10011" /db_xref="UniProtKB/Swiss-Prot:P37485" /translation="MKQTRALMEGAILISLFAIITLLVVYVPVIGTILLFALPLPMIL YTIRHGLKLGIWMGAVSLPVVFIVGSFNGLIVAFMSACAGIAMGHFFKRKEPGHAIIS GALIYMLSIVFYFVISIQFLGINIIDEAMTQYRQSLDIVETVAKQSGNAGQFEKQLKL MEEQLGIVQYLFPTAIVMVGVIFSFLSYLIAKPLLRRFSPDIPNLKPFRELKFPQSVV VLYLIIVMLSFLPLEKGQMLYSIALNGEFILGFLIFIQGLSFIFFYCHKKQYPKAAAV IAVILGFVHPVFMAAIRILGVLDMGFHIRNKVK*" /label="yybS CDS" gene complement(3816774..3817703) /gene="yybS" /locus_tag="BSU_40520" /old_locus_tag="BSU40520" /label="yybS gene" S_feature complement(3817704..3817840) /Source="Nicolas_S_feature" /locus_tag="new_4166589_4166725_c" /HighExp="H2O2, G150, G180, Cold, Paraq, G135, Oxctl, Salt, Etha, BMM" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigB" /TUshortPSig="1, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1560" promotor_-10 complement(3817822..3817841) /Source="Nicolas_upshift_promotors" /id="U3193" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.416583416583417" /psig=1 /xcortree=2490 /SigmaFactorBS="cttttcctttttcatgtttcacatgaaacattagcgtcaTTT TACttgcgatttggactTATGTTAAAATATAAAAGTAaaatttagagatgatataaaa a" /listShort="S1560, yybS, yybT, rplI" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3817840) /Source="Nicolas_upshifts" /id="U3193" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.416583416583417" /psig=1 /xcortree=2490 /SigmaFactorBS="cttttcctttttcatgtttcacatgaaacattagcgtcaTTT TACttgcgatttggactTATGTTAAAATATAAAAGTAaaatttagagatgatataaaa a" /listShort="S1560, yybS, yybT, rplI" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3817856..3817861) /Source="Nicolas_upshift_promotors" /id="U3193" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.416583416583417" /psig=1 /xcortree=2490 /SigmaFactorBS="cttttcctttttcatgtttcacatgaaacattagcgtcaTTT TACttgcgatttggactTATGTTAAAATATAAAAGTAaaatttagagatgatataaaa a" /listShort="S1560, yybS, yybT, rplI" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3817930..3818079) /gene="yyzH" /locus_tag="BSU_40529" /old_locus_tag="BSU40529" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_003097802.1" /db_xref="EnsemblGenomes-Gn:BSU40529" /db_xref="EnsemblGenomes-Tr:CAX52718" /db_xref="GOA:C0H3U2" /db_xref="UniProtKB/Swiss-Prot:C0H3U2" /translation="MWDMIKNFFLFSSGVLQATTLLLVILIFMYVRKTKKKNKESSGF MDDKH*" /label="yyzH CDS" gene complement(3817930..3818079) /gene="yyzH" /locus_tag="BSU_40529" /old_locus_tag="BSU40529" /label="yyzH gene" downshifts complement(3817956) /Source="Nicolas_upshifts" /id="D2098" /incds=0 /nref=1 /ntot=44 /MaxReadThrough="6.98636" /MaxDrop="3.23568" /score="-6.7107279" /energy="-8.4" /TU="U3194" /idTUdmin="U3197" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3818118..3818137) /Source="Nicolas_upshift_promotors" /id="U3194" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=247 /SigmaFactorBS="catatcagcatatgcccaacgctcaatgttgttcatgaTGTT TTGaagtttttaaaaaGGGAAATTCACCTTATATAGgatacgggttgagaacatgcac a" /listShort="yyzH, S1560, yybS, yybT" /listLong="rplI" /label="promotor_-10" upshifts complement(3818135) /Source="Nicolas_upshifts" /id="U3194" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=247 /SigmaFactorBS="catatcagcatatgcccaacgctcaatgttgttcatgaTGTT TTGaagtttttaaaaaGGGAAATTCACCTTATATAGgatacgggttgagaacatgcac a" /listShort="yyzH, S1560, yybS, yybT" /listLong="rplI" /label="upshifts" promotor_-35 complement(3818151..3818157) /Source="Nicolas_upshift_promotors" /id="U3194" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=247 /SigmaFactorBS="catatcagcatatgcccaacgctcaatgttgttcatgaTGTT TTGaagtttttaaaaaGGGAAATTCACCTTATATAGgatacgggttgagaacatgcac a" /listShort="yyzH, S1560, yybS, yybT" /listLong="rplI" /label="promotor_-35" promotor_-35 3818158..3818167 /Source="Nicolas_upshift_promotors" /id="U3195" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1292 /SigmaFactorBS="ggtgaatttccctttttaaaaacttcaaaacaTCATGAACAA cattgagcgttgGGCATATGCTGATATGGAATctgatcgataaaggagaattttcaca t" /listShort="cotF, S1562, ppaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3818180..3818199 /Source="Nicolas_upshift_promotors" /id="U3195" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1292 /SigmaFactorBS="ggtgaatttccctttttaaaaacttcaaaacaTCATGAACAA cattgagcgttgGGCATATGCTGATATGGAATctgatcgataaaggagaattttcaca t" /listShort="cotF, S1562, ppaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3818186 /Source="Nicolas_upshifts" /id="U3195" /multdbtbs="SigK" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1292 /SigmaFactorBS="ggtgaatttccctttttaaaaacttcaaaacaTCATGAACAA cattgagcgttgGGCATATGCTGATATGGAATctgatcgataaaggagaattttcaca t" /listShort="cotF, S1562, ppaC" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(3818198) /Source="Nicolas_upshifts" /id="U3196" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=698 /SigmaFactorBS="tttcatgccaagccaatgttctgcgttcaTCCATgtgaaaat TCTCCTTTATCGATCagattccatatcagcatatgcccaacgctcaatgttgttcatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3818200..3818713) /Source="Nicolas_S_feature" /locus_tag="new_4167085_4167598_c" /HighExp="dia5, Diami, H2O2, Salt, dia15, Etha, Paraq, LPhT, G180, C30" /AntisenseName="cotF" /AntisenseCor="-0.33406696665100499" /AntisenseRegPval="-7.7" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1561" promotor_-10 complement(3818202..3818216) /Source="Nicolas_upshift_promotors" /id="U3196" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=698 /SigmaFactorBS="tttcatgccaagccaatgttctgcgttcaTCCATgtgaaaat TCTCCTTTATCGATCagattccatatcagcatatgcccaacgctcaatgttgttcatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3818225..3818229) /Source="Nicolas_upshift_promotors" /id="U3196" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp=1 /psig=0 /xcortree=698 /SigmaFactorBS="tttcatgccaagccaatgttctgcgttcaTCCATgtgaaaat TCTCCTTTATCGATCagattccatatcagcatatgcccaacgctcaatgttgttcatg a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3818225..3818707 /gene="cotF" /locus_tag="BSU_40530" /old_locus_tag="BSU40530" /function="16.13: Shape" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:1708381, 19933362, 23335421" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 1708381, 19933362, 23335421; Product type s: structure" /codon_start=1 /transl_table=11 /product="spore coat protein" /protein_id="NP_391933.1" /db_xref="EnsemblGenomes-Gn:BSU40530" /db_xref="EnsemblGenomes-Tr:CAB16090" /db_xref="GOA:P23261" /db_xref="InterPro:IPR012347" /db_xref="InterPro:IPR012851" /db_xref="InterPro:IPR016493" /db_xref="SubtiList:BG10012" /db_xref="UniProtKB/Swiss-Prot:P23261" /translation="MDERRTLAWHETLEMHELVAFQSNGLIKLKKMIREVKDPQLRQL YNVSIQGVEQNLRELLPFFPQAPHREDEEEERADNPFYSGDLLGFAKTSVRSYAIAIT ETATPQLRNVLVKQLNAAIQLHAQVYRYMYQHGYYPSYNLSELLKNDVRNANRAISMK *" /label="cotF CDS" gene 3818225..3818707 /gene="cotF" /locus_tag="BSU_40530" /old_locus_tag="BSU40530" /label="cotF gene" downshifts 3818694 /Source="Nicolas_upshifts" /id="D2099" /incds=0 /nref=20 /ntot=52 /MaxReadThrough="5.45774" /MaxDrop="4.1869" /score="-3.60126456" /energy="-16.9" /TU="U3195" /idTUdmin="U3195" /TUdmin="-1540" /isTUend="FALSE" /label="downshifts" CDS complement(3818737..3819114) /gene="hypR" /locus_tag="BSU_40540" /old_locus_tag="BSU40540" /function="16.8: Protect" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:22238377" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 22238377; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (Cys-activated by oxidative stress)" /protein_id="NP_391934.1" /db_xref="EnsemblGenomes-Gn:BSU40540" /db_xref="EnsemblGenomes-Tr:CAB16091" /db_xref="GOA:P37486" /db_xref="InterPro:IPR002577" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="PDB:4A5M" /db_xref="PDB:4A5N" /db_xref="SubtiList:BG10013" /db_xref="UniProtKB/Swiss-Prot:P37486" /translation="MSEKKNIYPNKEGCPVEFTLDVIGGKWKGILFYHMIDGKKRFNE FRRICPSITQRMLTLQLRELEADGIVHREVYHQVPPKVEYSLTEFGRTLEPIVLQMKE WGESNRDVLESYRSNGLVKDQQK*" /label="hypR CDS" gene complement(3818737..3819114) /gene="hypR" /locus_tag="BSU_40540" /old_locus_tag="BSU40540" /label="hypR gene" S_feature 3818739..3819268 /Source="Nicolas_S_feature" /locus_tag="new_4167624_4168153" /HighExp="S8, S6, S7, BT, S5, B36, C30, B60, G/S, Pyr" /AntisenseName="yybR" /AntisenseCor="-0.26586375565089998" /AntisenseRegPval="-5" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1562" downshifts complement(3818758) /Source="Nicolas_upshifts" /id="D2100" /incds=0 /nref=124 /ntot=240 /MaxReadThrough="4.32896" /MaxDrop="5.38963" /score="10.6464065" /energy="-15.3" /TU="U3197" /idTUdmin="U3197" /TUdmin="-802" /isTUend="FALSE" /label="downshifts" promotor_-10 complement(3819169..3819188) /Source="Nicolas_upshift_promotors" /id="U3197" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.776223776223776" /psig="0.997002997002997" /xcortree=1958 /SigmaFactorBS="cccttaaaaattgatgtgaataagaagcatttTCTTTGAGct aaggagaaaagGTGTGTAAAATACTGGGTAGattagttgcaaaatgtaatgtagtatc a" /listShort="yybR, S1561, yyzH" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3819181) /Source="Nicolas_upshifts" /id="U3197" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.776223776223776" /psig="0.997002997002997" /xcortree=1958 /SigmaFactorBS="cccttaaaaattgatgtgaataagaagcatttTCTTTGAGct aaggagaaaagGTGTGTAAAATACTGGGTAGattagttgcaaaatgtaatgtagtatc a" /listShort="yybR, S1561, yyzH" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3819202..3819209) /Source="Nicolas_upshift_promotors" /id="U3197" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.776223776223776" /psig="0.997002997002997" /xcortree=1958 /SigmaFactorBS="cccttaaaaattgatgtgaataagaagcatttTCTTTGAGct aaggagaaaagGTGTGTAAAATACTGGGTAGattagttgcaaaatgtaatgtagtatc a" /listShort="yybR, S1561, yyzH" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3819250..3819254 /Source="Nicolas_upshift_promotors" /id="U3198" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.661338661338661" /psig=1 /xcortree=2340 /SigmaFactorBS="aaatgcttcttattcacatcaatttttaagggtttgcatgAT TACacctgcagcaagaCGTGTTAAACTATATAAAGAttacactacttaaaaaaggata g" /listShort="ppaC" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3819268..3819287 /Source="Nicolas_upshift_promotors" /id="U3198" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.661338661338661" /psig=1 /xcortree=2340 /SigmaFactorBS="aaatgcttcttattcacatcaatttttaagggtttgcatgAT TACacctgcagcaagaCGTGTTAAACTATATAAAGAttacactacttaaaaaaggata g" /listShort="ppaC" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3819270 /Source="Nicolas_upshifts" /id="U3198" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.661338661338661" /psig=1 /xcortree=2340 /SigmaFactorBS="aaatgcttcttattcacatcaatttttaagggtttgcatgAT TACacctgcagcaagaCGTGTTAAACTATATAAAGAttacactacttaaaaaaggata g" /listShort="ppaC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3819295..3819309) /Source="Nicolas_upshift_promotors" /id="U3199" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.553446553446553" /psig="0.393606393606394" /xcortree=309 /SigmaFactorBS="tatctgggttttggtgtccgaaaataagtatctttTcCATga tagctccTATCCTTTTTTAAGTagtgtaatctttatatagtttaacacgtcttgctgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3819298) /Source="Nicolas_upshifts" /id="U3199" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.553446553446553" /psig="0.393606393606394" /xcortree=309 /SigmaFactorBS="tatctgggttttggtgtccgaaaataagtatctttTcCATga tagctccTATCCTTTTTTAAGTagtgtaatctttatatagtttaacacgtcttgctgc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 3819319..3820248 /gene="ppaC" /locus_tag="BSU_40550" /old_locus_tag="BSU40550" /EC_number="3.6.1.1" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:9782505, 12682299, 15044829, 17611193, 9782505, 21749987, 22938038" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9782505, 12682299, 15044829, 17611193, 9782505, 21749987, 22938038; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="inorganic pyrophosphatase (Mn2+-dependent)" /protein_id="NP_391935.1" /db_xref="EnsemblGenomes-Gn:BSU40550" /db_xref="EnsemblGenomes-Tr:CAB16092" /db_xref="GOA:P37487" /db_xref="InterPro:IPR001667" /db_xref="InterPro:IPR004097" /db_xref="InterPro:IPR022934" /db_xref="PDB:1K23" /db_xref="PDB:1WPM" /db_xref="PDB:1WPN" /db_xref="PDB:2HAW" /db_xref="PDB:2IW4" /db_xref="SubtiList:BG10014" /db_xref="UniProtKB/Swiss-Prot:P37487" /translation="MEKILIFGHQNPDTDTICSAIAYADLKNKLGFNAEPVRLGQVNG ETQYALDYFKQESPRLVETAANEVNGVILVDHNERQQSIKDIEEVQVLEVIDHHRIAN FETAEPLYYRAEPVGCTATILNKMYKENNVKIEKEIAGLMLSAIISDSLLFKSPTCTD QDVAAAKELAEIAGVDAEEYGLNMLKAGADLSKKTVEELISLDAKEFTLGSKKVEIAQ VNTVDIEDVKKRQAELEAVISKVVAEKNLDLFLLVITDILENDSLALAIGNEAAKVEK AFNVTLENNTALLKGVVSRKKQVVPVLTDAMAE*" /label="ppaC CDS" gene 3819319..3820248 /gene="ppaC" /locus_tag="BSU_40550" /old_locus_tag="BSU40550" /label="ppaC gene" downshifts 3820234 /Source="Nicolas_upshifts" /id="D2101" /incds=0 /nref=235 /ntot=270 /MaxReadThrough="2.06965" /MaxDrop="8.02492" /score="25.8885382" /energy="-11.7" /TU="NA" /idTUdmin="U3195" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(3820277) /Source="Nicolas_upshifts" /id="D2102" /incds=0 /nref=14 /ntot=136 /MaxReadThrough="1.08899" /MaxDrop="4.94065" /score="19.3488922" /energy="-11.7" /TU="NA" /idTUdmin="U3200" /TUdmin=33 /isTUend="FALSE" /label="downshifts" CDS complement(3820281..3820727) /gene="yybP" /locus_tag="BSU_40560" /old_locus_tag="BSU40560" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15096624, 25794618, 25794619; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative manganese-binding lipoprotein" /protein_id="NP_391936.1" /db_xref="EnsemblGenomes-Gn:BSU40560" /db_xref="EnsemblGenomes-Tr:CAB16093" /db_xref="GOA:P37488" /db_xref="SubtiList:BG10015" /db_xref="UniProtKB/Swiss-Prot:P37488" /translation="MKIILTVLAGVGLLSAGGCGMLDQVNDGLNYTSEAAGYVEKVKT FAEEAPELAEKAVNDTEAKEKLEAQLESIQKAAADFNELTPPDAAAEIHRTIQEHNET LQKSAEDVLKQAEEGKVSLKELEQSDLVQNAKQITDVMGQIEKLGE*" /label="yybP CDS" gene complement(3820281..3820727) /gene="yybP" /locus_tag="BSU_40560" /old_locus_tag="BSU40560" /label="yybP gene" S_feature complement(3820728..3821058) /Source="Nicolas_S_feature" /locus_tag="new_4169613_4169943_c" /HighExp="S8, Cold, S7, S6, H2O2, S5, S4, Etha, G180, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.998614" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1563" misc_RNA complement(3820917..3821034) /gene="mswM" /locus_tag="BSU_misc_RNA_94" /product="manganese ion binding riboswitch" /experiment="publication(s) with functional evidences, PMID:25794618, 25794619" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 25794618, 25794619; Product type n: RNA" /label="mswM RNA" gene complement(3820917..3821034) /gene="mswM" /locus_tag="BSU_misc_RNA_94" /label="mswM gene" promotor_-10 complement(3821049..3821068) /Source="Nicolas_upshift_promotors" /id="U3200" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.743256743256743" /psig=1 /xcortree=672 /SigmaFactorBS="cacagcgcgcttttatataaacggcaggAATTTGACtggaac agatcggTGCTTTAGAATGAAAGTAATaaaaatgaacactccaaaggggagtagcttt c" /listShort="S1563, yybP" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3821057) /Source="Nicolas_upshifts" /id="U3200" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.743256743256743" /psig=1 /xcortree=672 /SigmaFactorBS="cacagcgcgcttttatataaacggcaggAATTTGACtggaac agatcggTGCTTTAGAATGAAAGTAATaaaaatgaacactccaaaggggagtagcttt c" /listShort="S1563, yybP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3821082..3821089) /Source="Nicolas_upshift_promotors" /id="U3200" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.743256743256743" /psig=1 /xcortree=672 /SigmaFactorBS="cacagcgcgcttttatataaacggcaggAATTTGACtggaac agatcggTGCTTTAGAATGAAAGTAATaaaaatgaacactccaaaggggagtagcttt c" /listShort="S1563, yybP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3821095..3821101 /Source="Nicolas_upshift_promotors" /id="U3201" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=178 /SigmaFactorBS="tttcattctaaagcaccgatctgttccagtcaaattcctgcC GTTTATataaaagcgcgctgTGGTATTTAAAATTTGAATggtttttctatcaggagat c" /listShort="yybO" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3821114 /Source="Nicolas_upshifts" /id="U3201" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=178 /SigmaFactorBS="tttcattctaaagcaccgatctgttccagtcaaattcctgcC GTTTATataaaagcgcgctgTGGTATTTAAAATTTGAATggtttttctatcaggagat c" /listShort="yybO" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3821116..3821134 /Source="Nicolas_upshift_promotors" /id="U3201" /multdbtbs="-" /comp="M11" /sig="SigB" /pcomp=1 /psig=1 /xcortree=178 /SigmaFactorBS="tttcattctaaagcaccgatctgttccagtcaaattcctgcC GTTTATataaaagcgcgctgTGGTATTTAAAATTTGAATggtttttctatcaggagat c" /listShort="yybO" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 3821130..3821136 /Source="Nicolas_upshift_promotors" /id="U3202" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.58941058941059" /psig="0.58941058941059" /xcortree=736 /SigmaFactorBS="ttatataaaagcgcgctgtggtatttaaaattTGAATGGttt ttctatcaggaGATCATGCTATGacagaggaggttttcatcatgagtcaagagcgcgt g" /listShort="yybO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3821151..3821162 /Source="Nicolas_upshift_promotors" /id="U3202" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.58941058941059" /psig="0.58941058941059" /xcortree=736 /SigmaFactorBS="ttatataaaagcgcgctgtggtatttaaaattTGAATGGttt ttctatcaggaGATCATGCTATGacagaggaggttttcatcatgagtcaagagcgcgt g" /listShort="yybO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3821158 /Source="Nicolas_upshifts" /id="U3202" /multdbtbs="-" /comp="M8" /sig="SigGF" /pcomp="0.58941058941059" /psig="0.58941058941059" /xcortree=736 /SigmaFactorBS="ttatataaaagcgcgctgtggtatttaaaattTGAATGGttt ttctatcaggaGATCATGCTATGacagaggaggttttcatcatgagtcaagagcgcgt g" /listShort="yybO" /GFF_Attribute="listLong" /label="upshifts" CDS 3821160..3822467 /gene="yybO" /locus_tag="BSU_40570" /old_locus_tag="BSU40570" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_391937.1" /db_xref="EnsemblGenomes-Gn:BSU40570" /db_xref="EnsemblGenomes-Tr:CAB16094" /db_xref="GOA:P37489" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10016" /db_xref="UniProtKB/Swiss-Prot:P37489" /translation="MTEEVFIMSQERVKRPGHTRWYISSLLSGIIILNYFDRVAISVA APAIQDSFHLTATELGIVFSIYTYSYTLMQLPVGSLLDRFGVAWVTRVGMTIWSFLTI LLAFLQGKLLLYLFRFLIGLTSASAFPAASKATALWFPPSERGLANSLFDSAAKFSNV IGAPLVAFLVTTFDWRVAFLTIGCINVLFTIFFWQYYEQPERHKRISKSELNYIQKHN AITTEQIPYKTGPLLKKLFTNRKVWGLMIGFTGYGYTFNLLLTWLPTFFKHTYGMDLM SSGLFTAVPWLISTISGIAVGGWLVDYFIKKGYPNTKVYRTVIIVGMSFGFFFLGSIL TNNITVAIICISIGLAGISATAPVGWSISAELAPIGSVSMLSSMVNLANNLFGGIIAA SLTGYLFDVTGSFTLSFLVAGFVLLLGLVFYVFVLGDVKRIKL*" /label="yybO CDS" gene 3821160..3822467 /gene="yybO" /locus_tag="BSU_40570" /old_locus_tag="BSU40570" /label="yybO gene" downshifts complement(3822268) /Source="Nicolas_upshifts" /id="D2103" /incds=1 /nref=1 /ntot=11 /MaxReadThrough="0.73662" /MaxDrop="2.97868" /score="30.543563" /energy="-17.9" /TU="NA" /idTUdmin="U3203" /TUdmin=264 /isTUend="FALSE" /label="downshifts" downshifts 3822456 /Source="Nicolas_upshifts" /id="D2104" /incds=0 /nref=7 /ntot=55 /MaxReadThrough="2.76545" /MaxDrop="3.99898" /score="-3.44083304" /energy="-17.9" /TU="NA" /idTUdmin="U3201" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3822511..3822750) /gene="yyzI" /locus_tag="BSU_40573" /old_locus_tag="BSU40573" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="PSEUDO:CAX52719.1" /translation="MNYKKQNQGFGSISGDHNDIHDILATIEENGTQDAFHYEGGLQG KNEQVLEQIEQEMLASGLDIEEQDEEKVNGDGPIL*" /label="yyzI CDS" gene complement(3822511..3822750) /gene="yyzI" /locus_tag="BSU_40573" /old_locus_tag="BSU40573" /pseudo /label="yyzI gene" downshifts complement(3822532) /Source="Nicolas_upshifts" /id="D2105" /incds=0 /nref=4 /ntot=114 /MaxReadThrough="3.05613" /MaxDrop="4.69729" /score="30.543563" /energy="-17.9" /TU="NA" /idTUdmin="U3203" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_no_box complement(3822536..3822636) /Source="Nicolas_upshift_promotors" /id="U3203" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.552447552447552" /psig="0.010989010989011" /xcortree=1485 /SigmaFactorBS="gaaggtggtcttcaaggaaaaaacgagcaggtgctcgaacag atagagcaggaaatgctagcttcggggcttgatatagaggaacaggacgaggagaagg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_no_box" upshifts complement(3822576) /Source="Nicolas_upshifts" /id="U3203" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.552447552447552" /psig="0.010989010989011" /xcortree=1485 /SigmaFactorBS="gaaggtggtcttcaaggaaaaaacgagcaggtgctcgaacag atagagcaggaaatgctagcttcggggcttgatatagaggaacaggacgaggagaagg t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3822740..3822904) /gene="yyzJ" /locus_tag="BSU_40574" /old_locus_tag="BSU40574" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="PSEUDO:CAX52720.1" /translation="MMIRGIHLEQQLKDIISACDVAIQNEDFDTLMNYYSERIMCKPR KQPPQRFCEL*" /label="yyzJ CDS" gene complement(3822740..3822904) /gene="yyzJ" /locus_tag="BSU_40574" /old_locus_tag="BSU40574" /pseudo /label="yyzJ gene" CDS complement(3822916..3823101) /locus_tag="BSU_40576" /old_locus_tag="BSU40576" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /codon_start=1 /transl_table=11 /product="hypothetical protein" /protein_id="YP_009514014.1" /translation="MSHQTKYPVNEAAIMPSNRLFARFTMELSMDTEPIGASSAEMDQ RNRKNKNEKDPYVSNIV*" /label="hypothetical protein CDS" gene complement(3822916..3823101) /locus_tag="BSU_40576" /old_locus_tag="BSU40576" /label="gene" downshifts 3823182 /Source="Nicolas_upshifts" /id="D2106" /incds=0 /nref=13 /ntot=90 /MaxReadThrough="0.18425" /MaxDrop="3.85413" /score="3.91893698" /energy="-13.7" /TU="NA" /idTUdmin="U3201" /TUdmin=726 /isTUend="FALSE" /label="downshifts" CDS complement(3823374..3823520) /gene="yyzK" /locus_tag="BSU_40578" /old_locus_tag="BSU40578" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="PSEUDO:CAX52721.1" /translation="MYGKTIKKRLEKIAFLFQEISKKRKEKIERSFVGSKQLHGLSYR RFRG*" /label="yyzK CDS" gene complement(3823374..3823520) /gene="yyzK" /locus_tag="BSU_40578" /old_locus_tag="BSU40578" /pseudo /label="yyzK gene" CDS complement(3823502..3823651) /gene="yyzL" /locus_tag="BSU_40579" /old_locus_tag="BSU40579" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 5: Unknown function" /pseudo /codon_start=1 /transl_table=11 /product="hypothetical protein" /db_xref="PSEUDO:CAX52722.1" /translation="MLNQHTLTYSTIDRKDYRSYKSNPEICLRILHKINETPESRYSV CMAKP*" /label="yyzL CDS" gene complement(3823502..3823651) /gene="yyzL" /locus_tag="BSU_40579" /old_locus_tag="BSU40579" /pseudo /label="yyzL gene" misc_feature complement(3823967..3823983) /Source="Nicolas_upshift_promotors" /id="U3204" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.330669330669331" /psig="0.761238761238761" /xcortree=650 /SigmaFactorBS="agattaactatattatatcttaactgtaataacctgtaaaga attttattgatagtattggATTTTATGTTATAAAGGaaaaagggtgggcgatttgctc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3823984) /Source="Nicolas_upshifts" /id="U3204" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.330669330669331" /psig="0.761238761238761" /xcortree=650 /SigmaFactorBS="agattaactatattatatcttaactgtaataacctgtaaaga attttattgatagtattggATTTTATGTTATAAAGGaaaaagggtgggcgatttgctc a" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3824003..3824010 /Source="Nicolas_upshift_promotors" /id="U3205" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2295 /SigmaFactorBS="ttcctttataacataaaatccaatactatcaataaaatTCTT TACAggttattacagttaAGATATAATATAGTTAATCTtttacgtaaaaggaggtttt t" /listShort="S1564, yybN, S1565, yybM, yybL, yybK, yybJ, S1567" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3824025..3824228 /Source="Nicolas_S_feature" /locus_tag="new_4172910_4173113" /HighExp="nit, T-3.40H, T-1.40H, T-0.40H, T0.0H, SMMPr, SMM, LoTm, ferm, T-4.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1564" promotor_-10 3824025..3824044 /Source="Nicolas_upshift_promotors" /id="U3205" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2295 /SigmaFactorBS="ttcctttataacataaaatccaatactatcaataaaatTCTT TACAggttattacagttaAGATATAATATAGTTAATCTtttacgtaaaaggaggtttt t" /listShort="S1564, yybN, S1565, yybM, yybL, yybK, yybJ, S1567" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3824025 /Source="Nicolas_upshifts" /id="U3205" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.955044955044955" /psig=1 /xcortree=2295 /SigmaFactorBS="ttcctttataacataaaatccaatactatcaataaaatTCTT TACAggttattacagttaAGATATAATATAGTTAATCTtttacgtaaaaggaggtttt t" /listShort="S1564, yybN, S1565, yybM, yybL, yybK, yybJ, S1567" /GFF_Attribute="listLong" /label="upshifts" misc_feature complement(3824046..3824060) /Source="Nicolas_upshift_promotors" /id="U3206" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.997002997002997" /psig=0 /xcortree=295 /SigmaFactorBS="tggggagatggagttactcctatttaaaacttcaacacaagt aataaaaaCCTCCTTTTACGTAAaagattaactatattatatcttaactgtaataacc t" /listShort="yyzL, yyzK" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3824050) /Source="Nicolas_upshifts" /id="U3206" /multdbtbs="-" /comp="M15" /sig="Sig-" /pcomp="0.997002997002997" /psig=0 /xcortree=295 /SigmaFactorBS="tggggagatggagttactcctatttaaaacttcaacacaagt aataaaaaCCTCCTTTTACGTAAaagattaactatattatatcttaactgtaataacc t" /listShort="yyzL, yyzK" /GFF_Attribute="listLong" /label="upshifts" CDS 3824229..3824666 /gene="yybN" /locus_tag="BSU_40580" /old_locus_tag="BSU40580" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 27902860" /codon_start=1 /transl_table=11 /product="conserved protein of unknown function" /protein_id="NP_391938.1" /db_xref="EnsemblGenomes-Gn:BSU40580" /db_xref="EnsemblGenomes-Tr:CAB16095" /db_xref="InterPro:IPR020208" /db_xref="SubtiList:BG10017" /db_xref="UniProtKB/Swiss-Prot:P37490" /translation="MNKFLKSNFRFLLAAALGISLLASSNFIKASNDNYKFHLLVPYG YGNAYSNDAFRQTTHTDNPWKVNLQKSAEGKGTIMTFWLINTGNSKIPKASKIHNVKQ GSGAHYYHANSQGSHTYVALAVENNNYSASSYGIDGVWDEETW*" /label="yybN CDS" gene 3824229..3824666 /gene="yybN" /locus_tag="BSU_40580" /old_locus_tag="BSU40580" /label="yybN gene" S_feature 3824667..3824743 /Source="Nicolas_S_feature" /locus_tag="new_4173552_4173628" /HighExp="M9-tran, SMMPr, MG 120, aero, GM 120, SMM, T-2.40H, T-4.40H, nit, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1565" downshifts 3824700 /Source="Nicolas_upshifts" /id="D2107" /incds=0 /nref=10 /ntot=98 /MaxReadThrough="6.91942" /MaxDrop="3.8662" /score="9.16494325" /energy="-9.5" /TU="U3205" /idTUdmin="U3201" /TUdmin=2244 /isTUend="FALSE" /label="downshifts" CDS 3824780..3825535 /gene="yybM" /locus_tag="BSU_40590" /old_locus_tag="BSU40590" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter permease subunit" /protein_id="NP_391939.1" /db_xref="EnsemblGenomes-Gn:BSU40590" /db_xref="EnsemblGenomes-Tr:CAB16096" /db_xref="SubtiList:BG10018" /db_xref="UniProtKB/Swiss-Prot:P37491" /translation="MESHIYRIIKNKLTIIIFTIIILIPCVDISLLLMTNTEYHPAYA FFLSGTSVGHASQMILLWFLPLYFLLLCADDSIQDYKTGYHYILISKVGRKKYCLEKI FTSFIISFLTMFLSLILNFLLVQVFFFKGTFKNDLDQIKFPDNSLYTFSMAHPYIAIV LFSIICCIMSGFVGALGSSLSLLFRDKKYAYPASFFIWFVLILKNKSLMFLFQPFTEY GYNVLLPILCLSIFIFLIIISSIVLYEAKYNEN*" /label="yybM CDS" gene 3824780..3825535 /gene="yybM" /locus_tag="BSU_40590" /old_locus_tag="BSU40590" /label="yybM gene" S_feature complement(3825375..3827964) /Source="Nicolas_S_feature" /locus_tag="new_4174260_4176850_c" /HighExp="S8, S6, S4, S5, S7, S3, C30, BT, G135, T5.0H" /AntisenseName="yybK" /AntisenseCor="-0.46686696237140402" /AntisenseRegPval="-15.2" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1566" CDS 3825525..3826235 /gene="yybL" /locus_tag="BSU_40600" /old_locus_tag="BSU40600" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative transporter permease subunit" /protein_id="NP_391940.1" /db_xref="EnsemblGenomes-Gn:BSU40600" /db_xref="EnsemblGenomes-Tr:CAB16097" /db_xref="SubtiList:BG10019" /db_xref="UniProtKB/Swiss-Prot:P37492" /translation="MKIKRLLLILCLLLFLVTLWFNQNHTYLGKNSIASLLYMNNSTF GYSSIFAYTLFYIVPFLMLLSNFFHSENPYKVMRMVKRKNYYKSKIMEIGFVSLLFSS IHTVINITCTHIFFSKNLLVEANFLSICLLNMISLVFFYLSVGIMFRLTYDLFNSVAL AIFIVYIILDSLYFGVKLLLPNGYWEPFRDLAIFTNMLNRYWSTSNLIIVYIRQIIIV FIFYLVGSSIFLNKDYKK*" /label="yybL CDS" gene 3825525..3826235 /gene="yybL" /locus_tag="BSU_40600" /old_locus_tag="BSU40600" /label="yybL gene" downshifts 3825734 /Source="Nicolas_upshifts" /id="D2108" /incds=1 /nref=1 /ntot=11 /MaxReadThrough="7.39982" /MaxDrop="2.95139" /score="9.16494325" /energy="-9.5" /TU="U3205" /idTUdmin="U3205" /TUdmin="-2354" /isTUend="FALSE" /label="downshifts" CDS 3826232..3826987 /gene="yybK" /locus_tag="BSU_40610" /old_locus_tag="BSU40610" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative transporter permease subunit" /protein_id="NP_391941.1" /db_xref="EnsemblGenomes-Gn:BSU40610" /db_xref="EnsemblGenomes-Tr:CAB16098" /db_xref="InterPro:IPR024295" /db_xref="SubtiList:BG10020" /db_xref="UniProtKB/Swiss-Prot:P37493" /translation="MRIKGFFITLVAIIFQASLSSYNNNKNVFPFLDGIPISTSGHYE YQNILLWFVPIVSLSFCFSGSIRDTYISYEQLKLVREHSRVKWVTSQFLIITVVLLIF TLSQIAIFYIYSLVSLHNLDINSVINKRFVMMTLMYYLTLLNLFSFQLFMELYYKSQI AQLNISVYIIFSLILAKKLVQLNSPKVIHYFLIPNYSNGLRTGLSYYSQSGTAIIEPL LGLFIIIILQISIVILSVLKFKKIDMLKSEGLQ*" /label="yybK CDS" gene 3826232..3826987 /gene="yybK" /locus_tag="BSU_40610" /old_locus_tag="BSU40610" /label="yybK gene" CDS 3826984..3827639 /gene="yybJ" /locus_tag="BSU_40620" /old_locus_tag="BSU40620" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 1938973; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative ATP-binding cassette subunit of transporter" /protein_id="NP_391942.1" /db_xref="EnsemblGenomes-Gn:BSU40620" /db_xref="EnsemblGenomes-Tr:CAB16099" /db_xref="GOA:P37494" /db_xref="InterPro:IPR003439" /db_xref="InterPro:IPR003593" /db_xref="InterPro:IPR017871" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10021" /db_xref="UniProtKB/Swiss-Prot:P37494" /translation="MIEVLNLTKKLKRLQF*IISLIHLKKEQFMDYLGVMVLERPCYF VHYPG**SLLKGV*LLKVNNYIKISLFLKV*D*L*KICSYFLSMMLLLTLKFCQKLKR SHQIMIY*ILLVELVWKILIV*RLVNSR*E*NND*ILHRLFLKNLIYCYLMNQQMRLM KKELHLFMTFFYKRKKGELPLLLLVITRKILYLYVTLH*K*IMDV*KLQKK*YIRKIV " /label="yybJ CDS" gene 3826984..3827639 /gene="yybJ" /locus_tag="BSU_40620" /old_locus_tag="BSU40620" /label="yybJ gene" S_feature 3827640..3827954 /Source="Nicolas_S_feature" /locus_tag="new_4176526_4176840" /HighExp="aero, Cold, HPh, nit, M/G, M9-tran, S1, SMM, LPh, T-4.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1567" downshifts 3827911 /Source="Nicolas_upshifts" /id="D2109" /incds=0 /nref=93 /ntot=227 /MaxReadThrough="3.45614" /MaxDrop="4.54398" /score="2.19825508" /energy="-10.3" /TU="U3205" /idTUdmin="U3205" /TUdmin="-176" /isTUend="FALSE" /label="downshifts" downshifts 3827955 /Source="Nicolas_upshifts" /id="D2110" /incds=0 /nref=1 /ntot=3 /MaxReadThrough="2.98662" /MaxDrop="3.29879" /score="2.19825508" /energy="-10.3" /TU="U3205" /idTUdmin="U3205" /TUdmin="-132" /isTUend="FALSE" /label="downshifts" downshifts complement(3828009) /Source="Nicolas_upshifts" /id="D2111" /incds=0 /nref=1 /ntot=24 /MaxReadThrough="3.53364" /MaxDrop="2.25148" /score="10.1219981" /energy="-6.3" /TU="U3207" /idTUdmin="U3209" /TUdmin=2266 /isTUend="FALSE" /label="downshifts" CDS complement(3828014..3828802) /gene="ictI" /locus_tag="BSU_40630" /old_locus_tag="BSU40630" /function="16.8: Protect" /function="16.5: Explore" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:16321932, 22882546, 25835496" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 16321932, 22882546, 25835496; Product type cp: cell process" /codon_start=1 /transl_table=11 /product="inner spore coat protein" /protein_id="NP_391943.1" /db_xref="EnsemblGenomes-Gn:BSU40630" /db_xref="EnsemblGenomes-Tr:CAB16100" /db_xref="SubtiList:BG10022" /db_xref="UniProtKB/Swiss-Prot:P37495" /translation="MNVYDIRMAPYWFYEGRGLVQHPYVFRQPVSSRAIIVSTRGDVT GDGVIDEVFLTGNQMPGSPLWRNITLVIRDGRTHQEQRIQLQNNMGYNPSLFLGDMTG DKIEDVAVVMDTGGSGGAIYAYVFAYLNRQFRRIFNSDVLNDELKYSVRYQNQYKASV ISHQQNETYILDLTYKGREYLNEIYNSQGVLKMPIEGWVNPLSGLYPVDFDRDGVYEL LAYQRIAGRYNADSLGYVQTVLKWNGQRFMFNRQTVTIFGSDLS*" /label="ictI CDS" gene complement(3828014..3828802) /gene="ictI" /locus_tag="BSU_40630" /old_locus_tag="BSU40630" /label="ictI gene" promotor_-10 complement(3828826..3828844) /Source="Nicolas_upshift_promotors" /id="U3207" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1128 /SigmaFactorBS="gataattcatatggtacggatttaattggtgtgtaagataTG TCTTtgatgtgccattcctGCATATAATGATTCATTCAgctgattagggaaggtgaca c" /listShort="yybI, S1566" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3828845) /Source="Nicolas_upshifts" /id="U3207" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1128 /SigmaFactorBS="gataattcatatggtacggatttaattggtgtgtaagataTG TCTTtgatgtgccattcctGCATATAATGATTCATTCAgctgattagggaaggtgaca c" /listShort="yybI, S1566" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3828860..3828865) /Source="Nicolas_upshift_promotors" /id="U3207" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp=1 /psig=1 /xcortree=1128 /SigmaFactorBS="gataattcatatggtacggatttaattggtgtgtaagataTG TCTTtgatgtgccattcctGCATATAATGATTCATTCAgctgattagggaaggtgaca c" /listShort="yybI, S1566" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3828870..3829259) /gene="yybH" /locus_tag="BSU_40640" /old_locus_tag="BSU40640" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391944.1" /db_xref="EnsemblGenomes-Gn:BSU40640" /db_xref="EnsemblGenomes-Tr:CAB16101" /db_xref="InterPro:IPR009959" /db_xref="InterPro:IPR032710" /db_xref="PDB:2GXF" /db_xref="SubtiList:BG10023" /db_xref="UniProtKB/Swiss-Prot:P37496" /translation="MEQQLKDIISACDLAIQNEDFDTLMNYYSEDAVLVVKPGMIARG KEEIKKAFITIANYFNHHIVPTQGKMILLEAGDTVLVLSQTLLDSDKKDSEYAMERRA TYVFKKNAQGEWLCVIDNSYGTDLIGV*" /label="yybH CDS" gene complement(3828870..3829259) /gene="yybH" /locus_tag="BSU_40640" /old_locus_tag="BSU40640" /label="yybH gene" promotor_-35 3829328..3829331 /Source="Nicolas_upshift_promotors" /id="U3208" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.544455544455544" /psig="0.999000999001" /xcortree=2554 /SigmaFactorBS="tcgctagaccactgaaaccttgaaaacaaAATGaaaagtatc cttttTTCCTATATAATCAAATAGAtatatttaacaaagtacccaagtgaaggggtga a" /listShort="yybG" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3829346..3829365 /Source="Nicolas_upshift_promotors" /id="U3208" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.544455544455544" /psig="0.999000999001" /xcortree=2554 /SigmaFactorBS="tcgctagaccactgaaaccttgaaaacaaAATGaaaagtatc cttttTTCCTATATAATCAAATAGAtatatttaacaaagtacccaagtgaaggggtga a" /listShort="yybG" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3829359 /Source="Nicolas_upshifts" /id="U3208" /multdbtbs="-" /comp="M7" /sig="SigA" /pcomp="0.544455544455544" /psig="0.999000999001" /xcortree=2554 /SigmaFactorBS="tcgctagaccactgaaaccttgaaaacaaAATGaaaagtatc cttttTTCCTATATAATCAAATAGAtatatttaacaaagtacccaagtgaaggggtga a" /listShort="yybG" /GFF_Attribute="listLong" /label="upshifts" CDS 3829405..3830244 /gene="yybG" /locus_tag="BSU_40650" /old_locus_tag="BSU40650" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms; PubMedId: 11709313, 12486061" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391945.1" /db_xref="EnsemblGenomes-Gn:BSU40650" /db_xref="EnsemblGenomes-Tr:CAB16102" /db_xref="InterPro:IPR001646" /db_xref="SubtiList:BG10024" /db_xref="UniProtKB/Swiss-Prot:P37497" /translation="MSAEVTLHDNIHYDLSADCQHCFGLCCVALPYAKSADFAFDKDG GTPCRNLQSNYQCSIHKDLREKGFRGCSAYECFGAGQKVSQITYEGKDWRNSPETANQ MFDVFPIMQQLHEMLWYLHEALSIDIAKPIHSELRTTFEKIERLTRLSKERLLTLQVD EHRAEVNEWLLKTSELVRAQARHPKLPKKVSRGSVLIGAKLKGLDLRGANLRGALLIA ADLRNADLRMTDFIGADMRDADLSGADLTGSIFLTQAQVNAANGDSNTKLPLSVRTPA HWK*" /label="yybG CDS" gene 3829405..3830244 /gene="yybG" /locus_tag="BSU_40650" /old_locus_tag="BSU40650" /label="yybG gene" downshifts 3830221 /Source="Nicolas_upshifts" /id="D2112" /incds=0 /nref=35 /ntot=188 /MaxReadThrough="1.19247" /MaxDrop="3.72166" /score="-0.156630814" /energy="-6.3" /TU="NA" /idTUdmin="U3208" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3830277..3831491) /gene="yybF" /locus_tag="BSU_40660" /old_locus_tag="BSU40660" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 9811656, 11557812, 12486061, 15849754, 16850406; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative permease" /protein_id="NP_391946.1" /db_xref="EnsemblGenomes-Gn:BSU40660" /db_xref="EnsemblGenomes-Tr:CAB16103" /db_xref="GOA:P37498" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10025" /db_xref="UniProtKB/Swiss-Prot:P37498" /translation="MTYIRKGTPVFRKITFAFFAAGFNTFAILYCVQPLMEEFTREFH VTPTAASLSLSVTTMLLAVSMLVFGSLSEVWGRKPIMGISMLAASVLCLASAFSPSFH TLLVLRTIQGVALAGLPSIAMAYLGEEIEPGSLGSAMGLYISGNAIGAVFGRIVSGLL SEYLNWHMAMGTIGVISLIASVIFFINLPPSRHFTPRKLKLGKLGMSLIGHLRDRKLF SLFLIGFLLLGSNVALFNYIVYVLLGPPYSLNKAFSSWIFIVMIVGIFSSSFIGRMVD RYGYPKILVMNIFIVIAGALFTINNMLAVKILGIALFTFGFFGGHSVASSWVGRRALH NKAQASSLYLFFYYAGSSVFGTIGGLFWSGFHWLGVVGMITFMLLVALWLSGYLARSV KMPDKRNEKGLN*" /label="yybF CDS" gene complement(3830277..3831491) /gene="yybF" /locus_tag="BSU_40660" /old_locus_tag="BSU40660" /label="yybF gene" downshifts complement(3830295) /Source="Nicolas_upshifts" /id="D2113" /incds=0 /nref=45 /ntot=169 /MaxReadThrough="1.92237" /MaxDrop="5.70619" /score="10.1219981" /energy="-6.3" /TU="NA" /idTUdmin="U3209" /TUdmin="-20" /isTUend="TRUE" /label="downshifts" S_feature complement(3831492..3831595) /Source="Nicolas_S_feature" /locus_tag="new_4180378_4180481_c" /HighExp="BI, B60, ferm, T0.30H, T-1.10H, T-0.40H, T-1.40H, T1.0H, nit, B36" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.94819299999999995" /TUshortSig="SigA" /TUshortPSig="0.996" /TUlongSig="NA" /TUlongPSig="NA" /label="S1568" promotor_-10 complement(3831588..3831607) /Source="Nicolas_upshift_promotors" /id="U3209" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.728271728271728" /psig="0.996003996003996" /xcortree=1589 /SigmaFactorBS="catataagcatgaaaaggatattttatatgCATTATACaaca tatatcaacGGTGCTAAGATAATAATATAaacagactcgaggatgtttgaattcgtaa g" /listShort="S1568, yybF" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 3831596..3831603 /Source="Nicolas_upshift_promotors" /id="U3210" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.627372627372627" /psig="0.997002997002997" /xcortree=2542 /SigmaFactorBS="aaacatcctcgagtctgtttatattatTATCTTAGcaccgtt gatataTGTTGTATAATGCATATAAAatatccttttcatgcttatatgtaataaggag a" /listShort="yybE" /GFF_Attribute="listLong" /label="promotor_-35" upshifts complement(3831598) /Source="Nicolas_upshifts" /id="U3209" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.728271728271728" /psig="0.996003996003996" /xcortree=1589 /SigmaFactorBS="catataagcatgaaaaggatattttatatgCATTATACaaca tatatcaacGGTGCTAAGATAATAATATAaacagactcgaggatgtttgaattcgtaa g" /listShort="S1568, yybF" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3831617..3831636 /Source="Nicolas_upshift_promotors" /id="U3210" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.627372627372627" /psig="0.997002997002997" /xcortree=2542 /SigmaFactorBS="aaacatcctcgagtctgtttatattatTATCTTAGcaccgtt gatataTGTTGTATAATGCATATAAAatatccttttcatgcttatatgtaataaggag a" /listShort="yybE" /GFF_Attribute="listLong" /label="promotor_-10" promotor_-35 complement(3831621..3831628) /Source="Nicolas_upshift_promotors" /id="U3209" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.728271728271728" /psig="0.996003996003996" /xcortree=1589 /SigmaFactorBS="catataagcatgaaaaggatattttatatgCATTATACaaca tatatcaacGGTGCTAAGATAATAATATAaacagactcgaggatgtttgaattcgtaa g" /listShort="S1568, yybF" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3831629 /Source="Nicolas_upshifts" /id="U3210" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.627372627372627" /psig="0.997002997002997" /xcortree=2542 /SigmaFactorBS="aaacatcctcgagtctgtttatattatTATCTTAGcaccgtt gatataTGTTGTATAATGCATATAAAatatccttttcatgcttatatgtaataaggag a" /listShort="yybE" /GFF_Attribute="listLong" /label="upshifts" CDS 3831678..3832556 /gene="yybE" /locus_tag="BSU_40670" /old_locus_tag="BSU40670" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 12169591, 17526699, 22720735; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (LysR family)" /protein_id="NP_391947.2" /db_xref="EnsemblGenomes-Gn:BSU40670" /db_xref="EnsemblGenomes-Tr:CAB16104" /db_xref="GOA:P37499" /db_xref="InterPro:IPR000847" /db_xref="InterPro:IPR005119" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10026" /db_xref="UniProtKB/Swiss-Prot:P37499" /translation="MEWEQLEYFQTLARMQHVTKAAKSLSITQPALSRSIARLENHLG VPLFDRQGRSISLNQYGHIFLRRVQAMMKEYTEGKEEIQALLKPDQGVVSLGFLHTLG TTLVPDLIGSFQQEYPNISFQLKQNHSYWLLERLKSGDLDLCLLASIKPENPIQWIKL WSEELFVFVPNDHPLASRESITLNEIAGERFILLKKGYALRMTVDELFEKANIQPNIM FEGEEATTAAGFVAAGLGISILPDLKGLDQSKITKIRVSWPECQRVIGIAWIKGRFLS PVAETFKQYVISHFSE*" /label="yybE CDS" gene 3831678..3832556 /gene="yybE" /locus_tag="BSU_40670" /old_locus_tag="BSU40670" /label="yybE gene" CDS 3832570..3833013 /gene="yybD" /locus_tag="BSU_40680" /old_locus_tag="BSU40680" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 28032445; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase" /protein_id="NP_391948.1" /db_xref="EnsemblGenomes-Gn:BSU40680" /db_xref="EnsemblGenomes-Tr:CAB16105" /db_xref="GOA:P37500" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG10027" /db_xref="UniProtKB/Swiss-Prot:P37500" /translation="MNVKKITSEQDLHTAFEIRKAVFVEEQGCPISDEFDEFDTLHGD CQHILAYHQNVPVGTARVRIVGHTGKLERICILKSYRKFGLGKVIVDALERIVKEQGI SAFKLHGQTQAAGFYEKLGYRTASEEFMLDGIPHVLMTKQDDSAL*" /label="yybD CDS" gene 3832570..3833013 /gene="yybD" /locus_tag="BSU_40680" /old_locus_tag="BSU40680" /label="yybD gene" CDS 3833096..3833575 /gene="yybC" /locus_tag="BSU_40690" /old_locus_tag="BSU40690" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 28032445; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral membrane protein" /protein_id="NP_391949.1" /db_xref="EnsemblGenomes-Gn:BSU40690" /db_xref="EnsemblGenomes-Tr:CAB16106" /db_xref="SubtiList:BG10028" /db_xref="UniProtKB/Swiss-Prot:P37501" /translation="MPANKKEGLIFGVMMCFGMVCVMSIYNAIINRAIYDFSLMTVFE MVIGFMIALLLDLLLVGPLAKKIAFRMPFDKTKKIYVILAMSTCMVIGMVLCMSVFGL VTAVLANGLNGDSLFSAYLMIVLKNFILAYPLQLLIMGPLVRGVFMKFVKPKLTAAI* " /label="yybC CDS" gene 3833096..3833575 /gene="yybC" /locus_tag="BSU_40690" /old_locus_tag="BSU40690" /label="yybC gene" downshifts 3833565 /Source="Nicolas_upshifts" /id="D2114" /incds=0 /nref=13 /ntot=97 /MaxReadThrough="0.69144" /MaxDrop="3.55998" /score="-9.53342462" /energy="-10.9" /TU="NA" /idTUdmin="U3210" /TUdmin=1628 /isTUend="FALSE" /label="downshifts" CDS complement(3833750..3834412) /gene="yybB" /locus_tag="BSU_40700" /old_locus_tag="BSU40700" /EC_number="3.-.-.-" /function="16.11: Scavenge (Catabolism)" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative hydrolase" /protein_id="NP_391950.1" /db_xref="EnsemblGenomes-Gn:BSU40700" /db_xref="EnsemblGenomes-Tr:CAB16107" /db_xref="GOA:P37502" /db_xref="InterPro:IPR001279" /db_xref="InterPro:IPR036866" /db_xref="SubtiList:BG10029" /db_xref="UniProtKB/Swiss-Prot:P37502" /translation="MNLRQLSEHVFQCEFELDVPLRIPVHTWFIKDGDDVYIVDTGIE RFADAQIRAALAIGNPKAILLTHGHSDHIGGASKWLERFDIPIFAHQKELKYINGEEP YPNKNEVENTGVAHIVQPLTEQTLAHLPLKYYLTPGHSPGHVVYYHKIDRTLLTGDLF ITSKEDLHPPIRRFSVDINENIDSGSIIDQIKPTLICSSHGEEILYNEELYKNYVVRY RD*" /label="yybB CDS" gene complement(3833750..3834412) /gene="yybB" /locus_tag="BSU_40700" /old_locus_tag="BSU40700" /label="yybB gene" CDS complement(3834559..3835011) /gene="yybA" /locus_tag="BSU_40710" /old_locus_tag="BSU40710" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 23504016; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional regulator (MarR family, polyamine export and degradation)" /protein_id="NP_391951.1" /db_xref="EnsemblGenomes-Gn:BSU40710" /db_xref="EnsemblGenomes-Tr:CAB16108" /db_xref="GOA:P37503" /db_xref="InterPro:IPR000835" /db_xref="InterPro:IPR023187" /db_xref="InterPro:IPR036388" /db_xref="InterPro:IPR036390" /db_xref="SubtiList:BG10030" /db_xref="UniProtKB/Swiss-Prot:P37503" /translation="MNDILREIGMIARALDSISNIEFKDLDLTRGQYLYLVRIYENPG IIQEKLAEMIKVDRTTAARAIKKLEMQGFIQKLPDEQNKKIKKLFPTEKGKKVYPLLR REGEHSTEVALSGFTSEEKETISALLHRVRKNIERDWEYVKKGNKRDY*" /label="yybA CDS" gene complement(3834559..3835011) /gene="yybA" /locus_tag="BSU_40710" /old_locus_tag="BSU40710" /label="yybA gene" promotor_-35 3835035..3835042 /Source="Nicolas_upshift_promotors" /id="U3211" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.706293706293706" /psig="0.998001998001998" /xcortree=1783 /SigmaFactorBS="aaatatcattcattcctaaaacccctcacgtattttTGTTGC AAttacaacaaaaatgTTTTAACCTTACTATTATAAgaccacatgcgtgctgtacagt c" /listShort="S1569, yyaT, yyaS" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3835057..3835076 /Source="Nicolas_upshift_promotors" /id="U3211" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.706293706293706" /psig="0.998001998001998" /xcortree=1783 /SigmaFactorBS="aaatatcattcattcctaaaacccctcacgtattttTGTTGC AAttacaacaaaaatgTTTTAACCTTACTATTATAAgaccacatgcgtgctgtacagt c" /listShort="S1569, yyaT, yyaS" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3835059 /Source="Nicolas_upshifts" /id="U3211" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.706293706293706" /psig="0.998001998001998" /xcortree=1783 /SigmaFactorBS="aaatatcattcattcctaaaacccctcacgtattttTGTTGC AAttacaacaaaaatgTTTTAACCTTACTATTATAAgaccacatgcgtgctgtacagt c" /listShort="S1569, yyaT, yyaS" /GFF_Attribute="listLong" /label="upshifts" S_feature 3835061..3835130 /Source="Nicolas_S_feature" /locus_tag="new_4183947_4184016" /HighExp="G135, G180, H2O2, LoTm, G150, Salt, Diami, Paraq, LBGstat, HiTm" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.998" /TUlongSig="NA" /TUlongPSig="NA" /label="S1569" promotor_-10 complement(3835064..3835083) /Source="Nicolas_upshift_promotors" /id="U3212" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.481518481518482" /psig="0.992007992007992" /xcortree=2273 /SigmaFactorBS="aatcaatccttttctgatattagTCTGGACTgtacagcacgc aTGTGGTCTTATAATAGTAAGgttaaaacatttttgttgtaattgcaacaaaaatacg t" /listShort="yybA, yybB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3835066) /Source="Nicolas_upshifts" /id="U3212" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.481518481518482" /psig="0.992007992007992" /xcortree=2273 /SigmaFactorBS="aatcaatccttttctgatattagTCTGGACTgtacagcacgc aTGTGGTCTTATAATAGTAAGgttaaaacatttttgttgtaattgcaacaaaaatacg t" /listShort="yybA, yybB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3835096..3835103) /Source="Nicolas_upshift_promotors" /id="U3212" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.481518481518482" /psig="0.992007992007992" /xcortree=2273 /SigmaFactorBS="aatcaatccttttctgatattagTCTGGACTgtacagcacgc aTGTGGTCTTATAATAGTAAGgttaaaacatttttgttgtaattgcaacaaaaatacg t" /listShort="yybA, yybB" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3835131..3835577 /gene="yyaT" /locus_tag="BSU_40720" /old_locus_tag="BSU40720" /EC_number="2.3.1.-" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyltransferase (polyamine degradation)" /protein_id="NP_391952.1" /db_xref="EnsemblGenomes-Gn:BSU40720" /db_xref="EnsemblGenomes-Tr:CAB16109" /db_xref="GOA:P37504" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG10031" /db_xref="UniProtKB/Swiss-Prot:P37504" /translation="MNIKRITTEADLHEALKIRRGVFIEEQHVSEADEFDEFDTLQEQ CQHILVYHENQPVGTGRARIVGHTAKLERICILKPYRKYGLGKIIVSGLEEIMKEKGL TSYKLHGQTQAAGFYQKLGYQISSQEFMEDGIPHVLMTKEISRNIT*" /label="yyaT CDS" gene 3835131..3835577 /gene="yyaT" /locus_tag="BSU_40720" /old_locus_tag="BSU40720" /label="yyaT gene" CDS 3835574..3836179 /gene="yyaS" /locus_tag="BSU_40730" /old_locus_tag="BSU40730" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 23504016; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protein" /protein_id="NP_391953.1" /db_xref="EnsemblGenomes-Gn:BSU40730" /db_xref="EnsemblGenomes-Tr:CAB16110" /db_xref="SubtiList:BG10032" /db_xref="UniProtKB/Swiss-Prot:P37505" /translation="MKYMYYGIGILILSLGISLTIQSGLGTSPFDALLVGLSKKIGLT VGSWEVLISVILLICNAILTRKKPILLGLITAFITGIGIDLWLFVVKNTIYLNSLLSK LICFGIGLVLIGLGTAIYLQTKFASTPIDHLTLIIRDLSKRTILFSRTLVYALFLVLA IIFKGPIGIGTLLTVCLGGMLLHVFMPIVERHFLSKNRRGY*" /label="yyaS CDS" gene 3835574..3836179 /gene="yyaS" /locus_tag="BSU_40730" /old_locus_tag="BSU40730" /label="yyaS gene" CDS complement(3836274..3836795) /gene="yyaR" /locus_tag="BSU_40740" /old_locus_tag="BSU40740" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 16579456, 23944997; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative acetyl-transferase" /protein_id="NP_391954.1" /db_xref="EnsemblGenomes-Gn:BSU40740" /db_xref="EnsemblGenomes-Tr:CAB16111" /db_xref="GOA:P37506" /db_xref="InterPro:IPR000182" /db_xref="InterPro:IPR008125" /db_xref="InterPro:IPR016181" /db_xref="SubtiList:BG10033" /db_xref="UniProtKB/Swiss-Prot:P37506" /translation="MIMKMTHLNMKDFNKPNEPFVVFGRMIPAFENGVWTYTEERFSK PYFKQYEDDDMDVSYVEEEGKAAFLYYLENNCIGRIKIRSNWNGYALIEDIAVAKDYR KKGVGTALLHKAIEWAKENHFCGLMLETQDINISACHFYAKHHFIIGAVDTMLYSNFP TANEIAIFWYYKF*" /label="yyaR CDS" gene complement(3836274..3836795) /gene="yyaR" /locus_tag="BSU_40740" /old_locus_tag="BSU40740" /label="yyaR gene" S_feature complement(3836796..3837623) /Source="Nicolas_S_feature" /locus_tag="new_4185682_4186509_c" /HighExp="T0.30H, Lbstat, H2O2, LPhT, T1.0H, dia15, Diami, T1.30H, dia5, M9-stat" /AntisenseName="yyaQ" /AntisenseCor="0.51412050904654805" /AntisenseRegPval="-18.8" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.997" /TUlongSig="NA" /TUlongPSig="NA" /label="S1570" promotor_-35 3836844..3836851 /Source="Nicolas_upshift_promotors" /id="U3213" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.667332667332667" /psig="0.955044955044955" /xcortree=607 /SigmaFactorBS="cgccaatcgagataatatttagtaaactcgtttcgatacTAT TCAACaacagcttccaaaaGTGTACTCTTTAAGAGAACAgcattagataaggcatcca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3836865 /Source="Nicolas_upshifts" /id="U3213" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.667332667332667" /psig="0.955044955044955" /xcortree=607 /SigmaFactorBS="cgccaatcgagataatatttagtaaactcgtttcgatacTAT TCAACaacagcttccaaaaGTGTACTCTTTAAGAGAACAgcattagataaggcatcca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3836866..3836885 /Source="Nicolas_upshift_promotors" /id="U3213" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.667332667332667" /psig="0.955044955044955" /xcortree=607 /SigmaFactorBS="cgccaatcgagataatatttagtaaactcgtttcgatacTAT TCAACaacagcttccaaaaGTGTACTCTTTAAGAGAACAgcattagataaggcatcca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" S_feature 3836931..3837205 /Source="Nicolas_S_feature" /locus_tag="new_4185817_4186091" /HighExp="LBGstat, G135, BC, G180, Sw, M9-stat, Diami, T0.30H, H2O2, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="0.13713" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1571" upshifts 3836931 /Source="Nicolas_upshifts" /id="U3214" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig="0.999000999001" /xcortree=2754 /SigmaFactorBS="ctctttaagagaacagcattagataaggcatccattacctta tatatttcactatcttaatgaGGTATTtcaacagaggctTGTGGTACAGTAAAAAGGA A" /listShort="S1571, yyaQ, S1572, yyaP" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 3836934..3836939 /Source="Nicolas_upshift_promotors" /id="U3214" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig="0.999000999001" /xcortree=2754 /SigmaFactorBS="ctctttaagagaacagcattagataaggcatccattacctta tatatttcactatcttaatgaGGTATTtcaacagaggctTGTGGTACAGTAAAAAGGA A" /listShort="S1571, yyaQ, S1572, yyaP" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3836952..3836971 /Source="Nicolas_upshift_promotors" /id="U3214" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.974025974025974" /psig="0.999000999001" /xcortree=2754 /SigmaFactorBS="ctctttaagagaacagcattagataaggcatccattacctta tatatttcactatcttaatgaGGTATTtcaacagaggctTGTGGTACAGTAAAAAGGA A" /listShort="S1571, yyaQ, S1572, yyaP" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3837206..3837562 /gene="yyaQ" /locus_tag="BSU_40750" /old_locus_tag="BSU40750" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391955.1" /db_xref="EnsemblGenomes-Gn:BSU40750" /db_xref="EnsemblGenomes-Tr:CAB16112" /db_xref="InterPro:IPR007351" /db_xref="SubtiList:BG10034" /db_xref="UniProtKB/Swiss-Prot:P37507" /translation="MLTREDIFKHVKEKYGTSPDYPWEKYPNYASLRHTSNKKWYGLI MNVLPEKLGLDGHGEIDILNLKCPPEISDRLRNGENILPGYHMDKEHWISIVLERTDP EGEIYNLIEQSFHLTK*" /label="yyaQ CDS" gene 3837206..3837562 /gene="yyaQ" /locus_tag="BSU_40750" /old_locus_tag="BSU40750" /label="yyaQ gene" S_feature 3837563..3837721 /Source="Nicolas_S_feature" /locus_tag="new_4186449_4186607" /HighExp="Sw, BC, G135, H2O2, LBGstat, G180, LPhT, T0.30H, Diami, dia15" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1572" promotor_-10 complement(3837605..3837624) /Source="Nicolas_upshift_promotors" /id="U3215" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.942057942057942" /psig="0.997002997002997" /xcortree=621 /SigmaFactorBS="cttctcccactctcgcaccagatgaactaagttgcgtTTGTG GACagagtgaagaacagTATCCTAAAATGAAAGTGCCcactactcttcgcagcttgat t" /listShort="S1570, yyaR" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3837623) /Source="Nicolas_upshifts" /id="U3215" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.942057942057942" /psig="0.997002997002997" /xcortree=621 /SigmaFactorBS="cttctcccactctcgcaccagatgaactaagttgcgtTTGTG GACagagtgaagaacagTATCCTAAAATGAAAGTGCCcactactcttcgcagcttgat t" /listShort="S1570, yyaR" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3837639..3837646) /Source="Nicolas_upshift_promotors" /id="U3215" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.942057942057942" /psig="0.997002997002997" /xcortree=621 /SigmaFactorBS="cttctcccactctcgcaccagatgaactaagttgcgtTTGTG GACagagtgaagaacagTATCCTAAAATGAAAGTGCCcactactcttcgcagcttgat t" /listShort="S1570, yyaR" /GFF_Attribute="listLong" /label="promotor_-35" CDS 3837722..3838288 /gene="yyaP" /locus_tag="BSU_40760" /old_locus_tag="BSU40760" /EC_number="1.-.-.-" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase" /protein_id="NP_391956.1" /db_xref="EnsemblGenomes-Gn:BSU40760" /db_xref="EnsemblGenomes-Tr:CAB16113" /db_xref="GOA:P37508" /db_xref="InterPro:IPR002734" /db_xref="InterPro:IPR024072" /db_xref="PDB:2GD9" /db_xref="SubtiList:BG10035" /db_xref="UniProtKB/Swiss-Prot:P37508" /translation="MTNNLKQRRIILDLAVTLDGFIEGKNGEVDWCIMDPDMGFTDFL NQIDTILYGRKSFDLWGQYIPKNEDPDTEKELWKLVHSKKKYVFSRTQNEIDNQAIFI NDNILEEVNKLKKNPGKDIWLYGGASLITTFINLGLVDEFRLSIHPVVLGEGKPLFID VKQRINLKMVNTRTFSSGVVQIVYHWNG*" /label="yyaP CDS" gene 3837722..3838288 /gene="yyaP" /locus_tag="BSU_40760" /old_locus_tag="BSU40760" /label="yyaP gene" CDS complement(3838795..3840171) /gene="tetB" /locus_tag="BSU_40770" /old_locus_tag="BSU40770" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:7961647, 14636065, 15849754, 16850406, 17015648, 25954268" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7961647, 14636065, 15849754, 16850406, 17015648, 25954268; Product type t : transporter" /codon_start=1 /transl_table=11 /product="multifunctional tetracycline-metal/H+ antiporterand Na+(K+)/H+ antiporter" /protein_id="NP_391957.1" /db_xref="EnsemblGenomes-Gn:BSU40770" /db_xref="EnsemblGenomes-Tr:CAB16114" /db_xref="GOA:P23054" /db_xref="InterPro:IPR011701" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10036" /db_xref="UniProtKB/Swiss-Prot:P23054" /translation="MNTSYSQSTLRHNQVLIWLCVLSFFSVLNEMVLNVSLPDIANEF NKLPASANWVNTAFMLTFSIGTALYGKLSDQLGIKNLLLFGIMVNGLGSIIGFVGHSF FPILILARFIQGIGAAAFPALVMVVVARYIPKENRGKAFGLIGSLVAMGEGVGPAIGG MVAHYIHWSYLLLIPTATIITVPFLIKLLKKEERIRGHIDMAGIILMSAGIVFFMLFT TSYRFSFLIISILAFFIFVQHIRKAQDPFVDPELGKNVFFVIGTLCGGLIFGTVAGFV SMVPYMMKDVHHLSTAAIGSGIIFPGTMSVIIFGYIGGLLVDRKGSLYVLTIGSALLS SGFLIAAFFIDAAPWIMTIIVIFVFGGLSFTKTVISTVVSSSLKEKEAGAGMSLLNFT SFLSEGTGIAIVGGLLSIGFLDHRLLPIDVDHSTYLYSNMLILFAGIIVICWLVILNV YKRSRRHG*" /label="tetB CDS" gene complement(3838795..3840171) /gene="tetB" /locus_tag="BSU_40770" /old_locus_tag="BSU40770" /label="tetB gene" CDS complement(3840205..3840267) /gene="tetL" /locus_tag="BSU_40780" /old_locus_tag="BSU40780" /function="16.3: Control" /function="16.1: Circulate" /experiment="publication(s) with functional evidences, PMID:14636065, 17015648" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 14636065, 17015648; Product type t: transporter" /codon_start=1 /transl_table=11 /product="tetracycline resistance leader peptide" /protein_id="NP_391958.1" /db_xref="EnsemblGenomes-Gn:BSU40780" /db_xref="EnsemblGenomes-Tr:CAB16115" /db_xref="GOA:P23053" /db_xref="InterPro:IPR012618" /db_xref="SubtiList:BG11051" /db_xref="UniProtKB/Swiss-Prot:P23053" /translation="MKCNKMNRVQLKEGSVSMTL*" /label="tetL CDS" gene complement(3840205..3840267) /gene="tetL" /locus_tag="BSU_40780" /old_locus_tag="BSU40780" /label="tetL gene" promotor_-10 complement(3840288..3840307) /Source="Nicolas_upshift_promotors" /id="U3216" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.635364635364635" /psig="0.998001998001998" /xcortree=2216 /SigmaFactorBS="ttgtttcgcaatctggtcaaatttttataaaaaaagtaaaAG TTTAATccttagtctataTATAATAAGATCATATCAATcaaatgtagggggagttatt a" /listShort="tetL, tetB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3840307) /Source="Nicolas_upshifts" /id="U3216" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.635364635364635" /psig="0.998001998001998" /xcortree=2216 /SigmaFactorBS="ttgtttcgcaatctggtcaaatttttataaaaaaagtaaaAG TTTAATccttagtctataTATAATAAGATCATATCAATcaaatgtagggggagttatt a" /listShort="tetL, tetB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3840320..3840327) /Source="Nicolas_upshift_promotors" /id="U3216" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.635364635364635" /psig="0.998001998001998" /xcortree=2216 /SigmaFactorBS="ttgtttcgcaatctggtcaaatttttataaaaaaagtaaaAG TTTAATccttagtctataTATAATAAGATCATATCAATcaaatgtagggggagttatt a" /listShort="tetL, tetB" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3840455..3840461 /Source="Nicolas_upshift_promotors" /id="U3217" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.612387612387612" /psig="0.998001998001998" /xcortree=618 /SigmaFactorBS="tttcacatcacaattatcgataagcagtcagtTATTGTAttt gtttaggataacTGTGGTAACCTGAATATAACcaacttaggaagaaggtgatcccatg c" /listShort="yyaO" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3840477..3840496 /Source="Nicolas_upshift_promotors" /id="U3217" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.612387612387612" /psig="0.998001998001998" /xcortree=618 /SigmaFactorBS="tttcacatcacaattatcgataagcagtcagtTATTGTAttt gtttaggataacTGTGGTAACCTGAATATAACcaacttaggaagaaggtgatcccatg c" /listShort="yyaO" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3840483 /Source="Nicolas_upshifts" /id="U3217" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.612387612387612" /psig="0.998001998001998" /xcortree=618 /SigmaFactorBS="tttcacatcacaattatcgataagcagtcagtTATTGTAttt gtttaggataacTGTGGTAACCTGAATATAACcaacttaggaagaaggtgatcccatg c" /listShort="yyaO" /GFF_Attribute="listLong" /label="upshifts" CDS 3840520..3840759 /gene="yyaO" /locus_tag="BSU_40790" /old_locus_tag="BSU40790" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391959.1" /db_xref="EnsemblGenomes-Gn:BSU40790" /db_xref="EnsemblGenomes-Tr:CAB16116" /db_xref="InterPro:IPR004879" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG10037" /db_xref="UniProtKB/Swiss-Prot:P37509" /translation="MPNKSKPNRLIAEKSPYLLQHAHNPVDWFPWGEEAFAKAKRENK PVLVSIGYSTTCHWWPGIIKSCGTPLKDNRSHFKR*" /label="yyaO CDS" gene 3840520..3840759 /gene="yyaO" /locus_tag="BSU_40790" /old_locus_tag="BSU40790" /label="yyaO gene" downshifts 3840768 /Source="Nicolas_upshifts" /id="D2115" /incds=0 /nref=7 /ntot=103 /MaxReadThrough="1.03879" /MaxDrop="3.89186" /score="10.758481" /energy="-8.2" /TU="NA" /idTUdmin="U3217" /TUdmin=9 /isTUend="TRUE" /label="downshifts" promotor_-35 3840852..3840859 /Source="Nicolas_upshift_promotors" /id="U3218" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.952047952047952" /psig="0.994005994005994" /xcortree=1993 /SigmaFactorBS="gcggtagcaggtttttttattTGCTTGACttagagttaactc taAATTGTAAACTAACTTTAATtaaatgagagggatgatgttgttgtattccattagt a" /listShort="yyaN" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3840875..3840894 /Source="Nicolas_upshift_promotors" /id="U3218" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.952047952047952" /psig="0.994005994005994" /xcortree=1993 /SigmaFactorBS="gcggtagcaggtttttttattTGCTTGACttagagttaactc taAATTGTAAACTAACTTTAATtaaatgagagggatgatgttgttgtattccattagt a" /listShort="yyaN" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3840891 /Source="Nicolas_upshifts" /id="U3218" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.952047952047952" /psig="0.994005994005994" /xcortree=1993 /SigmaFactorBS="gcggtagcaggtttttttattTGCTTGACttagagttaactc taAATTGTAAACTAACTTTAATtaaatgagagggatgatgttgttgtattccattagt a" /listShort="yyaN" /GFF_Attribute="listLong" /label="upshifts" CDS 3840910..3841326 /gene="yyaN" /locus_tag="BSU_40800" /old_locus_tag="BSU40800" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11948146, 14663075; Product type r: regulator" /codon_start=1 /transl_table=11 /product="putative transcriptional regulator (MerR family)" /protein_id="NP_391960.1" /db_xref="EnsemblGenomes-Gn:BSU40800" /db_xref="EnsemblGenomes-Tr:CAB16117" /db_xref="GOA:P37510" /db_xref="InterPro:IPR000551" /db_xref="InterPro:IPR009061" /db_xref="SubtiList:BG10038" /db_xref="UniProtKB/Swiss-Prot:P37510" /translation="MLLYSISKAAEKTSISSYTLRYYEKIGLLPPPKRKNSGRRFYTE TDIQFMLFLKSLKETGMSLEDINEFVKDGCILEKINSDVKSAQLSPSINKRIEILTKH LEKMEIKKRELEEVISTTKGKLDTYYSILKEEVENK*" /label="yyaN CDS" gene 3840910..3841326 /gene="yyaN" /locus_tag="BSU_40800" /old_locus_tag="BSU40800" /label="yyaN gene" CDS 3841323..3842240 /gene="yyaM" /locus_tag="BSU_40810" /old_locus_tag="BSU40810" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative efflux transporter" /protein_id="NP_391961.1" /db_xref="EnsemblGenomes-Gn:BSU40810" /db_xref="EnsemblGenomes-Tr:CAB16118" /db_xref="GOA:P37511" /db_xref="InterPro:IPR000620" /db_xref="SubtiList:BG10039" /db_xref="UniProtKB/Swiss-Prot:P37511" /translation="MKHLNIYIMLLGFSIFTGATFNLAKYTVGYFSPSSSAAWRFGLA AAVMLIILIFTEGIKKSQLRKNAVSYIVLGIIGIFGFNALFFVGLKYTSPVNGALIMG LNPLLTAILARIILKDNMTKKQVLGIFFAFIGVLLVITQGSIETIKTLSISGGDLIIF TGNVCWALYGVLGRRFVKDGTPLSTTTYTMVIGAVSLIVVSLFTSKPVSLSNIPIGVW GAIAFMAFFTSVLGYLWWNQGIKEIGASKTSLFFNLVPVVTMIISFAVGTPIKVFQVI GAVLVILGVLTASGVIRIPKYNTKEQSAI*" /label="yyaM CDS" gene 3841323..3842240 /gene="yyaM" /locus_tag="BSU_40810" /old_locus_tag="BSU40810" /label="yyaM gene" misc_feature 3842267..3842286 /Source="Nicolas_upshift_promotors" /id="U3219" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.841158841158841" /psig="0.984015984015984" /xcortree=1462 /SigmaFactorBS="actaaagaacagtcagctatataaagaaatagggagtatttt tgagaaaaTGTGTTAAGTTAAATATACActaattataggaagaaggtgatcccatgcc a" /listShort="yyaL" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts 3842277 /Source="Nicolas_upshifts" /id="U3219" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.841158841158841" /psig="0.984015984015984" /xcortree=1462 /SigmaFactorBS="actaaagaacagtcagctatataaagaaatagggagtatttt tgagaaaaTGTGTTAAGTTAAATATACActaattataggaagaaggtgatcccatgcc a" /listShort="yyaL" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3842281..3842300) /Source="Nicolas_upshift_promotors" /id="U3220" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.616383616383616" /psig="0.978021978021978" /xcortree=3109 /SigmaFactorBS="attgattaatctattgggtttactttTGTTTGGCatgggatc accttCTTCCTATAATTAGTGTATAtttaacttaacacattttctcaaaaatactccc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3842287) /Source="Nicolas_upshifts" /id="U3220" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.616383616383616" /psig="0.978021978021978" /xcortree=3109 /SigmaFactorBS="attgattaatctattgggtttactttTGTTTGGCatgggatc accttCTTCCTATAATTAGTGTATAtttaacttaacacattttctcaaaaatactccc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS 3842312..3844381 /gene="yyaL" /locus_tag="BSU_40820" /old_locus_tag="BSU40820" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 4: Unknown function but conserved in otherorganisms" /codon_start=1 /transl_table=11 /product="conserved hypothetical protein" /protein_id="NP_391962.1" /db_xref="EnsemblGenomes-Gn:BSU40820" /db_xref="EnsemblGenomes-Tr:CAB16119" /db_xref="GOA:P37512" /db_xref="InterPro:IPR004879" /db_xref="InterPro:IPR008928" /db_xref="InterPro:IPR024705" /db_xref="InterPro:IPR036249" /db_xref="SubtiList:BG10040" /db_xref="UniProtKB/Swiss-Prot:P37512" /translation="MPNKSKPNRLINEKSPYLLQHAHNPVDWFPWGEEAFEKAKRENK PVLVSIGYSTCHWCHVMAHESFEDEEIARLLNERFVAIKVDREERPDVDSVYMRICQL MTGQGGWPLNVFITPDQKPFYAGTYFPKTSKFNRPGFVDVLEHLSETFANDREHVEDI AENAAKHLQTKTAAKTGEGLSESAIHRTFQQLASGFDTIYGGFGQAPKFPMPHMLMYL LRYDHNTGQENALYNVTKTLDSMANGGIYDHIGYGFARYSTDDEWLVPHFEKMLYDNA LLLTAYTEAYQVTQNSRYKEICEQIITFIQREMTHEDGSFFSALDADTEGEEGKYYVW SKEEILKTLGDDLGTLYCQVYDITEEGNFEGKNIPNLIHTKREQIKEDAGLTEKELSL KLEDARQQLLKTREERTYPHVDDKVLTSWNALMIAGLAKAAKVYQEPKYLSLAKDAIT FIENKLIIDGRVMVRYRDGEVKNKGFIDDYAFLLWAYLDLYEASFDLSYLQKAKKLTD DMISLFWDEEHGGFYFTGHDAEALIVREKEVYDGAVPSGNSVAAVQLLRLGQVTGDLS LIEKAETMFSVFKPDIEAYPSGHAFFMQSVLRHLMPKKEIVIFGSADDPARKQIIAEL QKAFKPNDSILVAEQPEQCKDIAPFAADYRIIDGKTTVYICENFACQQPTTNIEEAIH TLISSRD*" /label="yyaL CDS" gene 3842312..3844381 /gene="yyaL" /locus_tag="BSU_40820" /old_locus_tag="BSU40820" /label="yyaL gene" promotor_-35 complement(3842314..3842321) /Source="Nicolas_upshift_promotors" /id="U3220" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.616383616383616" /psig="0.978021978021978" /xcortree=3109 /SigmaFactorBS="attgattaatctattgggtttactttTGTTTGGCatgggatc accttCTTCCTATAATTAGTGTATAtttaacttaacacattttctcaaaaatactccc t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3844345 /Source="Nicolas_upshifts" /id="D2116" /incds=0 /nref=221 /ntot=260 /MaxReadThrough="1.24617" /MaxDrop="5.71843" /score="11.6894527" /energy="-16.6" /TU="NA" /idTUdmin="U3219" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3844378..3845277) /gene="yyaK" /locus_tag="BSU_40830" /old_locus_tag="BSU40830" /function="16.6: Maintain" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 11343912, 15849754, 16850406; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative integral inner membrane protease" /protein_id="NP_391963.1" /db_xref="EnsemblGenomes-Gn:BSU40830" /db_xref="EnsemblGenomes-Tr:CAB16120" /db_xref="GOA:P37513" /db_xref="InterPro:IPR003675" /db_xref="SubtiList:BG10041" /db_xref="UniProtKB/Swiss-Prot:P37513" /translation="MNSFIRPIEGNNTLWRYFFAFLVMVGLYVLGNIAYLFAILFTVI VNPNITFDLDEAVLSDPLVDLYLSHVIYLFAIPGVWLAVRFILKRPFRTVITPNSKMN WRRISFGFIAYFLLMIAVQLIDFVIHPDSYSMQEFNASRFIWLLAAALILVPIQTSAE ELFFRGFLLQAFGRLTKNPLFLTLIVGGLFGVLHFANPEMNNGAVWAGIEYLTFGFVW TYYTIKTGSIEISLGAHAANNMFLCMFITEKNSVYGGIPSLFTVTRGNPMWEAFFTIA VNLVFAGIALWYHKKSKSKQQGS*" /label="yyaK CDS" gene complement(3844378..3845277) /gene="yyaK" /locus_tag="BSU_40830" /old_locus_tag="BSU40830" /label="yyaK gene" downshifts complement(3844421) /Source="Nicolas_upshifts" /id="D2117" /incds=0 /nref=65 /ntot=246 /MaxReadThrough="2.6155" /MaxDrop="3.91098" /score="23.2445146" /energy="-14.7" /TU="NA" /idTUdmin="U3221" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 complement(3845306..3845325) /Source="Nicolas_upshift_promotors" /id="U3221" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.839160839160839" /psig="0.98001998001998" /xcortree=2400 /SigmaFactorBS="ttatattttaattttgcttaaaagatttccaaaacAGTAGAT TcatagaccaatttaTGCAAATATATAGTAATATTctcattgaaaggaagagacatag a" /listShort="yyaK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3845322) /Source="Nicolas_upshifts" /id="U3221" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.839160839160839" /psig="0.98001998001998" /xcortree=2400 /SigmaFactorBS="ttatattttaattttgcttaaaagatttccaaaacAGTAGAT TcatagaccaatttaTGCAAATATATAGTAATATTctcattgaaaggaagagacatag a" /listShort="yyaK" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3845324..3846555) /Source="Nicolas_S_feature" /locus_tag="new_4194210_4195441_c" /HighExp="S6, S8, S7, S5, B36, BT, S4, B60, S3, Diami" /AntisenseName="yyaJ" /AntisenseCor="-0.24400480530035801" /AntisenseRegPval="-4.3" /CDS_PredictionProba="NA" /TUshortSig="SigK" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1573" promotor_-35 complement(3845340..3845347) /Source="Nicolas_upshift_promotors" /id="U3221" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.839160839160839" /psig="0.98001998001998" /xcortree=2400 /SigmaFactorBS="ttatattttaattttgcttaaaagatttccaaaacAGTAGAT TcatagaccaatttaTGCAAATATATAGTAATATTctcattgaaaggaagagacatag a" /listShort="yyaK" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-35 3845418..3845425 /Source="Nicolas_upshift_promotors" /id="U3222" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.725274725274725" /psig="0.978021978021978" /xcortree=3158 /SigmaFactorBS="tgtgaatttagttcttccatctagtgatttgaaCTCTGTTGc caatgaaccaagATACTTATAATAGTCCCAAGaggggaattttcagtcttttctacta c" /listShort="yyaJ" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3845439..3845458 /Source="Nicolas_upshift_promotors" /id="U3222" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.725274725274725" /psig="0.978021978021978" /xcortree=3158 /SigmaFactorBS="tgtgaatttagttcttccatctagtgatttgaaCTCTGTTGc caatgaaccaagATACTTATAATAGTCCCAAGaggggaattttcagtcttttctacta c" /listShort="yyaJ" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3845445 /Source="Nicolas_upshifts" /id="U3222" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.725274725274725" /psig="0.978021978021978" /xcortree=3158 /SigmaFactorBS="tgtgaatttagttcttccatctagtgatttgaaCTCTGTTGc caatgaaccaagATACTTATAATAGTCCCAAGaggggaattttcagtcttttctacta c" /listShort="yyaJ" /GFF_Attribute="listLong" /label="upshifts" CDS 3845503..3846858 /gene="yyaJ" /locus_tag="BSU_40840" /old_locus_tag="BSU40840" /function="16.1: Circulate" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 9529885, 19087206, 22720735; Product type t : transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_391964.2" /db_xref="EnsemblGenomes-Gn:BSU40840" /db_xref="EnsemblGenomes-Tr:CAB16121" /db_xref="GOA:P37514" /db_xref="InterPro:IPR005828" /db_xref="InterPro:IPR020846" /db_xref="InterPro:IPR036259" /db_xref="SubtiList:BG10042" /db_xref="UniProtKB/Swiss-Prot:P37514" /translation="MNTIFKQKNTHPFSNAANRLDRLPISRVHFQVLTALGIVYFFDL ADLFTLSNVAPALIEHWGIPLSTIANVTAASFLGMFLGASLGGRLSDRIGRKKALNLF VFVFSIASLCNAAAWDIPSLMTFRFLTGFGVAAAMVITNSYLAEFFPSSVRGKYISFC AMIGLIGVPITNIVSAFVIPLGSWGWRLVFVWGAVGLIYFFFIHRLEESPRWHENRGE YAKADAILTRIEEQVEKEKGPLPAASQPKVSETVKQNAGYAGLLKGRNLKITIVLSAV WIFETFGFYGFASWVPSLLKSNGVTMENTLWYNVLHSVGAPLGALLGSMISERFQRKW ILAASAFLTAIAGLLYGMTFIPIMIIVFGFIVNITERVFTSNLYAYTSEPYPTEYRSS GSGLAYGLGRFSNIFGSLLVGFIAVQLGYISVFLFIGGCWLACSLLLIFFGPNTNAKQ I*" /label="yyaJ CDS" gene 3845503..3846858 /gene="yyaJ" /locus_tag="BSU_40840" /old_locus_tag="BSU40840" /label="yyaJ gene" promotor_-10 complement(3846541..3846560) /Source="Nicolas_upshift_promotors" /id="U3223" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1260 /SigmaFactorBS="aggtaaagacccgttctgtgatattcacgataaaaccaaata CAATGATCATgatgggaataaaaGTCATACCATATAAGAGCCCggcgatggccgtcag a" /listShort="S1573, yyaK" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3846565) /Source="Nicolas_upshifts" /id="U3223" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1260 /SigmaFactorBS="aggtaaagacccgttctgtgatattcacgataaaaccaaata CAATGATCATgatgggaataaaaGTCATACCATATAAGAGCCCggcgatggccgtcag a" /listShort="S1573, yyaK" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3846574..3846583) /Source="Nicolas_upshift_promotors" /id="U3223" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp=1 /psig=1 /xcortree=1260 /SigmaFactorBS="aggtaaagacccgttctgtgatattcacgataaaaccaaata CAATGATCATgatgggaataaaaGTCATACCATATAAGAGCCCggcgatggccgtcag a" /listShort="S1573, yyaK" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3846892..3847446) /gene="maa" /locus_tag="BSU_40850" /old_locus_tag="BSU40850" /EC_number="2.3.1.79" /function="16.8: Protect" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12731863, 12793527, 19087206, 22226636, 22720735; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="maltose O-acetyltransferase" /protein_id="NP_391965.1" /db_xref="EnsemblGenomes-Gn:BSU40850" /db_xref="EnsemblGenomes-Tr:CAB16122" /db_xref="GOA:P37515" /db_xref="InterPro:IPR001451" /db_xref="InterPro:IPR011004" /db_xref="InterPro:IPR018357" /db_xref="InterPro:IPR024688" /db_xref="SubtiList:BG10043" /db_xref="UniProtKB/Swiss-Prot:P37515" /translation="MLRTEKEKMAAGELYNSEDQQLLLERKHARQLIRQYNETPEDDA VRTKLLKELLGSVGDQVTILPTFRCDYGYHIHIGDHTFVNFDCVILDVCEVRIGCHCL IAPGVHIYTAGHPLDPIERKSGKEFGKPVTIGDQVWIGGRAVINPGVTIGDNAVIASG SVVTKDVPANTVVGGNPARILKQL*" /label="maa CDS" gene complement(3846892..3847446) /gene="maa" /locus_tag="BSU_40850" /old_locus_tag="BSU40850" /label="maa gene" CDS complement(3847464..3847844) /gene="yyaH" /locus_tag="BSU_40860" /old_locus_tag="BSU40860" /function="16.11: Scavenge (Catabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 19087206; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative C-S lyase" /protein_id="NP_391966.1" /db_xref="EnsemblGenomes-Gn:BSU40860" /db_xref="EnsemblGenomes-Tr:CAB16123" /db_xref="InterPro:IPR004360" /db_xref="InterPro:IPR029068" /db_xref="SubtiList:BG10044" /db_xref="UniProtKB/Swiss-Prot:P37516" /translation="MQIEHTAVWVNDLERMKSFYESYFNGEANDLYHNEKKDFKSYFI TFDSGARLEIMKKGNVTDPPSQTMTGWAHIAFSVGSREKVDELTDRLKADGFAVVNGP RTTGDGYYESVIEDDEGNLIEITI*" /label="yyaH CDS" gene complement(3847464..3847844) /gene="yyaH" /locus_tag="BSU_40860" /old_locus_tag="BSU40860" /label="yyaH gene" CDS complement(3847900..3848835) /gene="ccpB" /locus_tag="BSU_40870" /old_locus_tag="BSU40870" /function="16.3: Control" /experiment="publication(s) with functional evidences, PMID:9457849, 9642180, 16267306" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 9457849, 9642180, 16267306; Product type r: regulator" /codon_start=1 /transl_table=11 /product="transcriptional repressor of carbon supply (LacIfamily)" /protein_id="NP_391967.1" /db_xref="EnsemblGenomes-Gn:BSU40870" /db_xref="EnsemblGenomes-Tr:CAB16124" /db_xref="GOA:P37517" /db_xref="InterPro:IPR000843" /db_xref="InterPro:IPR001761" /db_xref="InterPro:IPR010982" /db_xref="InterPro:IPR028082" /db_xref="SubtiList:BG10045" /db_xref="UniProtKB/Swiss-Prot:P37517" /translation="MANIKEIARLANVSVSTVSRVLNHHPYVSEEKRKLVHQVMKELD YTPNRTAIDLIRGKTHTVGVILPYSDHPCFDKIVNGITKAAFQHEYATTLLPTNYNPD IEIKYLELLRTKKIDGLIITSRANHWDSILAYQEYGPVIACEDTGDIDVPCAFNDRKT AYAESFRYLKSRGHENIAFTCVREADRSPSTADKAAAYKAVCGRLEDRHMLSGCNDMN DGELAAEHFYMSGRVPTAIYANSDEVAAGIHLFAKKNNWDVEIIGEGNTSISRVLGFP SLDLNLEQLGIAAFSLFLQDEPADIKIQHKFKKKA*" /label="ccpB CDS" gene complement(3847900..3848835) /gene="ccpB" /locus_tag="BSU_40870" /old_locus_tag="BSU40870" /label="ccpB gene" promotor_-35 3848825..3848834 /Source="Nicolas_upshift_promotors" /id="U3224" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=1390 /SigmaFactorBS="gatacatttgccagtcttgcgatctcttttATATTTGCCAtc tctttctccttTTCATATAAAAAAAGCAGTAagtgtaaaatccttactgctatctcat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 3848848..3848867 /Source="Nicolas_upshift_promotors" /id="U3224" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=1390 /SigmaFactorBS="gatacatttgccagtcttgcgatctcttttATATTTGCCAtc tctttctccttTTCATATAAAAAAAGCAGTAagtgtaaaatccttactgctatctcat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3848855 /Source="Nicolas_upshifts" /id="U3224" /multdbtbs="-" /comp="M5" /sig="SigK" /pcomp="0.967032967032967" /psig="0.967032967032967" /xcortree=1390 /SigmaFactorBS="gatacatttgccagtcttgcgatctcttttATATTTGCCAtc tctttctccttTTCATATAAAAAAAGCAGTAagtgtaaaatccttactgctatctcat c" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3848879..3848898) /Source="Nicolas_upshift_promotors" /id="U3225" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5004995004995" /psig="0.998001998001998" /xcortree=2935 /SigmaFactorBS="atatcagcggacgtcatgggttccgaccattgtccTGTTGAA CttatcatcaataTATGATGAGATAGCAGTAAGgattttacacttactgcttttttta t" /listShort="ccpB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3848893) /Source="Nicolas_upshifts" /id="U3225" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5004995004995" /psig="0.998001998001998" /xcortree=2935 /SigmaFactorBS="atatcagcggacgtcatgggttccgaccattgtccTGTTGAA CttatcatcaataTATGATGAGATAGCAGTAAGgattttacacttactgcttttttta t" /listShort="ccpB" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3848894..3849652) /gene="exoA" /locus_tag="BSU_40880" /old_locus_tag="BSU40880" /EC_number="3.1.11.2" /function="16.6: Maintain" /function="16.8: Protect" /experiment="publication(s) with functional evidences, PMID:10540738, 16237020, 18203828, 21441501, 24244006, 24914186" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 10540738, 16237020, 18203828, 21441501, 24244006, 24914186; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="apurinic/apyrimidinic endonuclease" /protein_id="NP_391968.1" /db_xref="EnsemblGenomes-Gn:BSU40880" /db_xref="EnsemblGenomes-Tr:CAB16125" /db_xref="GOA:P37454" /db_xref="InterPro:IPR004808" /db_xref="InterPro:IPR005135" /db_xref="InterPro:IPR020847" /db_xref="InterPro:IPR020848" /db_xref="InterPro:IPR036691" /db_xref="PDB:5CFE" /db_xref="SubtiList:BG10046" /db_xref="UniProtKB/Swiss-Prot:P37454" /translation="MKLISWNVNGLRAVMRKMDFLSYLKEEDADIICLQETKIQDGQV DLQPEDYHVYWNYAVKKGYSGTAVFSKQEPLQVIYGIGVEEHDQEGRVITLEFENVFV MTVYTPNSRRGLERIDYRMQWEEALLSYILELDQKKPVILCGDLNVAHQEIDLKNPKA NRNNAGFSDQEREAFTRFLEAGFVDSFRHVYPDLEGAYSWWSYRAGARDRNIGWRIDY FVVSESLKEQIEDASISADVMGSDHCPVELIINI*" /label="exoA CDS" gene complement(3848894..3849652) /gene="exoA" /locus_tag="BSU_40880" /old_locus_tag="BSU40880" /label="exoA gene" promotor_-35 complement(3848911..3848918) /Source="Nicolas_upshift_promotors" /id="U3225" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.5004995004995" /psig="0.998001998001998" /xcortree=2935 /SigmaFactorBS="atatcagcggacgtcatgggttccgaccattgtccTGTTGAA CttatcatcaataTATGATGAGATAGCAGTAAGgattttacacttactgcttttttta t" /listShort="ccpB" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3849185..3849688 /Source="Nicolas_S_feature" /locus_tag="new_4198071_4198574" /HighExp="C30, S8, S7, S6, BT, S5, M/G, Glucon, C90, T1.0H" /AntisenseName="exoAA" /AntisenseCor="-0.177921457862244" /AntisenseRegPval="-2.5" /CDS_PredictionProba="NA" /TUshortSig="NA" /TUshortPSig="NA" /TUlongSig="NA" /TUlongPSig="NA" /label="S1574" downshifts 3849647 /Source="Nicolas_upshifts" /id="D2118" /incds=0 /nref=2 /ntot=12 /MaxReadThrough="2.65789" /MaxDrop="4.11352" /score="16.4680636" /energy="-6.8" /TU="NA" /idTUdmin="U3224" /TUdmin=528 /isTUend="FALSE" /label="downshifts" CDS complement(3849717..3849956) /gene="rpsR" /locus_tag="BSU_40890" /old_locus_tag="BSU40890" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14762004, 22720735, 24310371" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14762004, 22720735, 24310371; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S18" /protein_id="NP_391969.2" /db_xref="EnsemblGenomes-Gn:BSU40890" /db_xref="EnsemblGenomes-Tr:CAB16126" /db_xref="GOA:P21475" /db_xref="InterPro:IPR001648" /db_xref="InterPro:IPR018275" /db_xref="InterPro:IPR036870" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10047" /db_xref="UniProtKB/Swiss-Prot:P21475" /translation="MAGGRRGGRAKRRKVCYFTSNGITHIDYKDVDLLKKFVSERGKI LPRRVTGTNAKYQRKLTAAIKRARQMALLPYVSGE*" /label="rpsR CDS" gene complement(3849717..3849956) /gene="rpsR" /locus_tag="BSU_40890" /old_locus_tag="BSU40890" /label="rpsR gene" downshifts complement(3849723) /Source="Nicolas_upshifts" /id="D2119" /incds=0 /nref=217 /ntot=268 /MaxReadThrough="4.97781" /MaxDrop="7.46952" /score="21.7622917" /energy="-15.3" /TU="U3226,U3227" /idTUdmin="U3229" /TUdmin=0 /isTUend="TRUE" /label="downshifts" downshifts complement(3849791) /Source="Nicolas_upshifts" /id="D2120" /incds=1 /nref=13 /ntot=142 /MaxReadThrough="8.89363" /MaxDrop="3.9797" /score="21.7622917" /energy="-15.3" /TU="U3226,U3227,U3229" /idTUdmin="U3229" /TUdmin="-68" /isTUend="FALSE" /label="downshifts" CDS complement(3850000..3850518) /gene="ssbA" /locus_tag="BSU_40900" /old_locus_tag="BSU40900" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:12682299, 14762004, 16549871, 10072765, 25138221, 26001966, 28575448" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14762004, 16549871, 10072765, 25138221, 26001966, 28575448; Product type f: factor" /codon_start=1 /transl_table=11 /product="single-strand DNA-binding protein" /protein_id="NP_391970.1" /db_xref="EnsemblGenomes-Gn:BSU40900" /db_xref="EnsemblGenomes-Tr:CAB16127" /db_xref="GOA:P37455" /db_xref="InterPro:IPR000424" /db_xref="InterPro:IPR011344" /db_xref="InterPro:IPR012340" /db_xref="SubtiList:BG10048" /db_xref="UniProtKB/Swiss-Prot:P37455" /translation="MLNRVVLVGRLTKDPELRYTPNGAAVATFTLAVNRTFTNQSGER EADFINCVTWRRQAENVANFLKKGSLAGVDGRLQTRNYENQQGQRVFVTEVQAESVQF LEPKNGGGSGSGGYNEGNSGGGQYFGGGQNDNPFGGNQNNQRRNQGNSFNDDPFANDG KPIDISDDDLPF*" /label="ssbA CDS" gene complement(3850000..3850518) /gene="ssbA" /locus_tag="BSU_40900" /old_locus_tag="BSU40900" /label="ssbA gene" CDS complement(3850559..3850846) /gene="rpsF" /locus_tag="BSU_40910" /old_locus_tag="BSU40910" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12682299, 14762004, 19653700, 26447183" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12682299, 14762004, 19653700, 26447183; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein S6 (BS9)" /protein_id="NP_391971.1" /db_xref="EnsemblGenomes-Gn:BSU40910" /db_xref="EnsemblGenomes-Tr:CAB16128" /db_xref="GOA:P21468" /db_xref="InterPro:IPR000529" /db_xref="InterPro:IPR014717" /db_xref="InterPro:IPR020814" /db_xref="InterPro:IPR020815" /db_xref="InterPro:IPR035980" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10049" /db_xref="UniProtKB/Swiss-Prot:P21468" /translation="MRKYEVMYIIRPNIDEESKKAVIERFNNVLTSNGAEITGTKDWG KRRLAYEINDFRDGFYQIVNVQSDAAAVQEFDRLAKISDDIIRHIVVKEEE*" /label="rpsF CDS" gene complement(3850559..3850846) /gene="rpsF" /locus_tag="BSU_40910" /old_locus_tag="BSU40910" /label="rpsF gene" S_feature complement(3850847..3850913) /Source="Nicolas_S_feature" /locus_tag="new_4199733_4199799_c" /HighExp="MG t5, LPhT, GM 90, SMM, T-5.40H, GM-0.2, MG 150, GM 45, Gly, M9-exp" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA, SigA" /TUshortPSig="1, 0.993, 0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1575" promotor_-10 complement(3850912..3850931) /Source="Nicolas_upshift_promotors" /id="U3226" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.443556443556444" /psig=1 /xcortree=2653 /SigmaFactorBS="tccgatttaatgtataggatgcaGTTGTAaagggacaagagc TTTGGTATAATATAAAATTGtgagtaatagaattattgctccttgcccattatgggcc g" /listShort="S1575, rpsF, ssbA, rpsR, exoAA, ccpB" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3850913) /Source="Nicolas_upshifts" /id="U3226" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.443556443556444" /psig=1 /xcortree=2653 /SigmaFactorBS="tccgatttaatgtataggatgcaGTTGTAaagggacaagagc TTTGGTATAATATAAAATTGtgagtaatagaattattgctccttgcccattatgggcc g" /listShort="S1575, rpsF, ssbA, rpsR, exoAA, ccpB" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3850945..3850950) /Source="Nicolas_upshift_promotors" /id="U3226" /multdbtbs="-" /comp="M17" /sig="SigA" /pcomp="0.443556443556444" /psig=1 /xcortree=2653 /SigmaFactorBS="tccgatttaatgtataggatgcaGTTGTAaagggacaagagc TTTGGTATAATATAAAATTGtgagtaatagaattattgctccttgcccattatgggcc g" /listShort="S1575, rpsF, ssbA, rpsR, exoAA, ccpB" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3850957..3852057) /gene="engD" /locus_tag="BSU_40920" /old_locus_tag="BSU40920" /function="16.6: Maintain" /function="16.8: Protect" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12837776, 16014871, 18713637, 21527254, 22995830, 26018081, 26160547, 26912459; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="potassium-dependent informational ATPase interacting with 70S ribosome; ROS stress regulator" /protein_id="NP_391972.1" /db_xref="EnsemblGenomes-Gn:BSU40920" /db_xref="EnsemblGenomes-Tr:CAB16129" /db_xref="GOA:P37518" /db_xref="InterPro:IPR004396" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR012675" /db_xref="InterPro:IPR012676" /db_xref="InterPro:IPR013029" /db_xref="InterPro:IPR023192" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031167" /db_xref="SubtiList:BG10050" /db_xref="UniProtKB/Swiss-Prot:P37518" /translation="MALTAGIVGLPNVGKSTLFNAITQAGAESANYPFCTIDPNVGIV EVPDDRLQKLTELVNPKKTVPTAFEFTDIAGIVKGASKGEGLGNKFLSHIRQVDAICH VVRAFSDDNITHVSGKVDPIDDIETINLELILADMETVEKRITRVSKLAKQKDKDAVF EFEILSKLKEAFESEKPARSVEFTEEQQKLVKQLHLLTSKPILYVANVSEDEVADPSG NENVAKIREYAAGENAEVIVVCAKIESEIAELEGEEKQMFLEELGIQESGLDQLIKAS YSLLGLATYFTAGEQEVRAWTFKKGMKAPECAGIIHSDFERGFIRAETVAYEDLLAGG GMAGAKEAGKVRLEGKEYVVQDGDVIHFRFNV*" /label="engD CDS" gene complement(3850957..3852057) /gene="engD" /locus_tag="BSU_40920" /old_locus_tag="BSU40920" /label="engD gene" promotor_-10 complement(3852105..3852124) /Source="Nicolas_upshift_promotors" /id="U3227" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.65034965034965" /psig="0.993006993006993" /xcortree=2193 /SigmaFactorBS="aagggattggcaagctgaaaatgcttttttgtcaGCTTGTCT tttccagtgaacctCCTTATAATTGCTCTAGGTTcaaaatacgttcatacaatgacgg t" /listShort="engD, S1575, rpsF, ssbA, rpsR, exoAA" /listLong="ccpB" /label="promotor_-10" upshifts complement(3852120) /Source="Nicolas_upshifts" /id="U3227" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.65034965034965" /psig="0.993006993006993" /xcortree=2193 /SigmaFactorBS="aagggattggcaagctgaaaatgcttttttgtcaGCTTGTCT tttccagtgaacctCCTTATAATTGCTCTAGGTTcaaaatacgttcatacaatgacgg t" /listShort="engD, S1575, rpsF, ssbA, rpsR, exoAA" /listLong="ccpB" /label="upshifts" promotor_-35 complement(3852139..3852146) /Source="Nicolas_upshift_promotors" /id="U3227" /multdbtbs="-" /comp="M14" /sig="SigA" /pcomp="0.65034965034965" /psig="0.993006993006993" /xcortree=2193 /SigmaFactorBS="aagggattggcaagctgaaaatgcttttttgtcaGCTTGTCT tttccagtgaacctCCTTATAATTGCTCTAGGTTcaaaatacgttcatacaatgacgg t" /listShort="engD, S1575, rpsF, ssbA, rpsR, exoAA" /listLong="ccpB" /label="promotor_-35" CDS complement(3852184..3854187) /gene="yyaE" /locus_tag="BSU_40930" /old_locus_tag="BSU40930" /EC_number="1.-.-.-" /function="3.2: Degradation" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 17114254, 20817769; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="putative oxidoreductase (molybdoenzyme)" /protein_id="NP_391973.1" /db_xref="EnsemblGenomes-Gn:BSU40930" /db_xref="EnsemblGenomes-Tr:CAB16130" /db_xref="GOA:P37519" /db_xref="InterPro:IPR006656" /db_xref="InterPro:IPR006657" /db_xref="InterPro:IPR006963" /db_xref="InterPro:IPR009010" /db_xref="SubtiList:BG10051" /db_xref="UniProtKB/Swiss-Prot:P37519" /translation="MSKVHQSACPLNCWDSCGFLVTVDDGKVTKVDGDPNHPITEGKI CGRGRMLETKTNSPDRLRYPMKKQNGEFVRISWEQALDEIADKLREIKETSETTAVLH SHDYANNGLLKALDQRFFNGYGGVTEIVGSICWGSGIEAQSWDFGRSYGHGPLDIYNS KHVVVWGRNVSRTNMHLYHHLQQVKKKGATITVIDPIFNPTAKLADRYISVKPGMDGW LAAAVLKVLIEMGRTDETFISEHSVGFDDVKELLKTVSLEEFIVKTETSMEELEYLAG LYADGPVSTFMGLGMQRYKNGGGTIRWIDALVAASGNVGIKGGGANFGNVQIGESFAK TKLTLPELKTTSRSFSMMTQAEEVLTAADPAIEMIIVTCGNPLTQVPNTNKVRQAFEK VPMTVAIDSIMTDTAELCDYVLPTATVFEEEDIYYSSMYHHYVQYGKKLVEPQGEAKS DSWIWSELAKRLGFGELFEYSTQEFLEMGLSSLEAEDVTLERLKEKGHLPLPVKQVPW DDYQFLTPSGKFEFTSSLAEQKGFSGSLQLNVPEESVFHNEELAGKYPYTLLSIHPQR SNHSQHVPFIEKLQHVQVDISPDIAAGQDLQDGDEVVIFNDRGSMKGKVKVMKQAHAK TINIDEGMWAAFGGSVNALTNDTNSDNGMGSTLFDCLVGLKKA*" /label="yyaE CDS" gene complement(3852184..3854187) /gene="yyaE" /locus_tag="BSU_40930" /old_locus_tag="BSU40930" /label="yyaE gene" CDS complement(3854238..3854444) /gene="yyzM" /locus_tag="BSU_40939" /old_locus_tag="BSU40939" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 21348639, 22333191, 27435445; Product type f: factor" /codon_start=1 /transl_table=11 /product="putative nucleic acid binding protein" /protein_id="YP_003097803.1" /db_xref="EnsemblGenomes-Gn:BSU40939" /db_xref="EnsemblGenomes-Tr:CAX52723" /db_xref="InterPro:IPR009296" /db_xref="UniProtKB/Swiss-Prot:C0H3V8" /translation="MADKDFGLNDIVEMKKPHPCGANSWKIIRMGMDIRIKCEGCSHS VMIPRREFERKLKKVLVKHEEPTS*" /label="yyzM CDS" gene complement(3854238..3854444) /gene="yyzM" /locus_tag="BSU_40939" /old_locus_tag="BSU40939" /label="yyzM gene" promotor_-10 complement(3854406..3854425) /Source="Nicolas_upshift_promotors" /id="U3228" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.83016983016983" /xcortree=1588 /SigmaFactorBS="ttttttgtacaatagatacagcagtttaggaaaagaggtgaa gggTCTTGGCggataaagactttgGCCTGAATGATATCGTAGAAatgaaaaaaccgca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3854431) /Source="Nicolas_upshifts" /id="U3228" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.83016983016983" /xcortree=1588 /SigmaFactorBS="ttttttgtacaatagatacagcagtttaggaaaagaggtgaa gggTCTTGGCggataaagactttgGCCTGAATGATATCGTAGAAatgaaaaaaccgca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3854440..3854446) /Source="Nicolas_upshift_promotors" /id="U3228" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.655344655344655" /psig="0.83016983016983" /xcortree=1588 /SigmaFactorBS="ttttttgtacaatagatacagcagtttaggaaaagaggtgaa gggTCTTGGCggataaagactttgGCCTGAATGATATCGTAGAAatgaaaaaaccgca t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3854470..3854489) /Source="Nicolas_upshift_promotors" /id="U3229" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.646353646353646" /psig="0.999000999001" /xcortree=1832 /SigmaFactorBS="ataagaggatgtatttcttttcgggtatcttGATTGctctta tgatcagtttTTTTGTACAATAGATACAGCagtttaggaaaagaggtgaagggtcttg g" /listShort="yyzM, yyaE, engD, S1575, rpsF, ssbA, rpsR" /listLong="exoAA" /label="promotor_-10" upshifts complement(3854481) /Source="Nicolas_upshifts" /id="U3229" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.646353646353646" /psig="0.999000999001" /xcortree=1832 /SigmaFactorBS="ataagaggatgtatttcttttcgggtatcttGATTGctctta tgatcagtttTTTTGTACAATAGATACAGCagtttaggaaaagaggtgaagggtcttg g" /listShort="yyzM, yyaE, engD, S1575, rpsF, ssbA, rpsR" /listLong="exoAA" /label="upshifts" promotor_-35 complement(3854506..3854510) /Source="Nicolas_upshift_promotors" /id="U3229" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.646353646353646" /psig="0.999000999001" /xcortree=1832 /SigmaFactorBS="ataagaggatgtatttcttttcgggtatcttGATTGctctta tgatcagtttTTTTGTACAATAGATACAGCagtttaggaaaagaggtgaagggtcttg g" /listShort="yyzM, yyaE, engD, S1575, rpsF, ssbA, rpsR" /listLong="exoAA" /label="promotor_-35" CDS complement(3854538..3855554) /gene="yyaD" /locus_tag="BSU_40940" /old_locus_tag="BSU40940" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16847258, 16850406; Product type t: transporter" /codon_start=1 /transl_table=11 /product="putative transporter" /protein_id="NP_391974.1" /db_xref="EnsemblGenomes-Gn:BSU40940" /db_xref="EnsemblGenomes-Tr:CAB16131" /db_xref="SubtiList:BG10052" /db_xref="UniProtKB/Swiss-Prot:P37520" /translation="MLWRAGMKWMLLILGSLIGAGYASGQEIWQFFGAESGLAIVLFT IMFIFSSYIVMKISFKVQSTHFLPVLEHLMGPWLAKIYDVLIIFYLFSTTMVMIAGGG VTLQMYKLPFWWGITLICIVTVCLFLWDVKGILSINSILIPVLVAGLLYALISFQSTH HHTWTIDLSQQYNWPASITFTSLNILSVVAILSSVGKEMKGLGEAKIASVASGLIFGV ISFVYNETLVELAGSLSQFEIPLFAVLEGAPYFLFLCMTAVLCLAIYTTTVAGLLGLS SRLMAFIHMPRWMIVLILLVLMVPFTSFGFSDLIAFLYPIYGMLNLYLLVCLLLYPIL SKWK*" /label="yyaD CDS" gene complement(3854538..3855554) /gene="yyaD" /locus_tag="BSU_40940" /old_locus_tag="BSU40940" /label="yyaD gene" promotor_-10 complement(3855587..3855605) /Source="Nicolas_upshift_promotors" /id="U3230" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=972 /SigmaFactorBS="tttcagcttgtgttcaaatgtctatgaaaatatGGCATGttt gctttcctttatTTATATAGTAACAATAACGggaacaagctgaactttgtctatgagg t" /listShort="yyaD" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3855599) /Source="Nicolas_upshifts" /id="U3230" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=972 /SigmaFactorBS="tttcagcttgtgttcaaatgtctatgaaaatatGGCATGttt gctttcctttatTTATATAGTAACAATAACGggaacaagctgaactttgtctatgagg t" /listShort="yyaD" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3855621..3855626) /Source="Nicolas_upshift_promotors" /id="U3230" /multdbtbs="SigE" /comp="M3" /sig="SigEF" /pcomp="0.996003996003996" /psig="0.996003996003996" /xcortree=972 /SigmaFactorBS="tttcagcttgtgttcaaatgtctatgaaaatatGGCATGttt gctttcctttatTTATATAGTAACAATAACGggaacaagctgaactttgtctatgagg t" /listShort="yyaD" /GFF_Attribute="listLong" /label="promotor_-35" downshifts complement(3855730) /Source="Nicolas_upshifts" /id="D2121" /incds=0 /nref=32 /ntot=184 /MaxReadThrough="1.8976" /MaxDrop="3.72136" /score="9.09987016" /energy="-7.4" /TU="NA" /idTUdmin="U3230" /TUdmin="-397" /isTUend="FALSE" /label="downshifts" promotor_-35 3855914..3855919 /Source="Nicolas_upshift_promotors" /id="U3231" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1073 /SigmaFactorBS="tcatgccctctacttttttaaaatctctggtgccatacacaa AGCATAaaaaatcatactgctGGATATACTGTAAACAACCttacataactacacacac c" /listShort="S1576, yyaC" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3855932..3856013 /Source="Nicolas_S_feature" /locus_tag="new_4204818_4204899" /HighExp="S4, S5, S3, S6, LoTm, S7, T5.0H, BT, M9-stat, T4.0H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigEF" /TUshortPSig="0.999" /TUlongSig="NA" /TUlongPSig="NA" /label="S1576" upshifts 3855932 /Source="Nicolas_upshifts" /id="U3231" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1073 /SigmaFactorBS="tcatgccctctacttttttaaaatctctggtgccatacacaa AGCATAaaaaatcatactgctGGATATACTGTAAACAACCttacataactacacacac c" /listShort="S1576, yyaC" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3855935..3855953 /Source="Nicolas_upshift_promotors" /id="U3231" /multdbtbs="SigF" /comp="M3" /sig="SigEF" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=1073 /SigmaFactorBS="tcatgccctctacttttttaaaatctctggtgccatacacaa AGCATAaaaaatcatactgctGGATATACTGTAAACAACCttacataactacacacac c" /listShort="S1576, yyaC" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3856014..3856631 /gene="sprC" /locus_tag="BSU_40950" /old_locus_tag="BSU40950" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 26362088; Product type e : enzyme" /codon_start=1 /transl_table=11 /product="spore-specific protease" /protein_id="NP_391975.1" /db_xref="EnsemblGenomes-Gn:BSU40950" /db_xref="EnsemblGenomes-Tr:CAB16132" /db_xref="InterPro:IPR009665" /db_xref="InterPro:IPR023430" /db_xref="SubtiList:BG10053" /db_xref="UniProtKB/Swiss-Prot:P37521" /translation="MNRKGGLFSSQERVKQYVSHTDAAAAKQIQTILSSSLRKAAGKP IVVVCIGTDRSTGDSLGPLVGMKLKQMQLTRFHVYGTLSDPVHAVNMKDKINDIHKLH KNPFVIAVDACLGRVKSVGSFQIGDGPLKPGAGVQKDLPEVGDLHINGIVNVSGFMEY FVLQNTRLNLVMNMANVLAEGLSLTDRTEWRQERLNPLQRLTGRI*" /label="sprC CDS" gene 3856014..3856631 /gene="sprC" /locus_tag="BSU_40950" /old_locus_tag="BSU40950" /label="sprC gene" promotor_-35 3856602..3856610 /Source="Nicolas_upshift_promotors" /id="U3232" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.440559440559441" /psig="0.440559440559441" /xcortree=291 /SigmaFactorBS="gaggcaagaacgccttaacCCGTTGCAAaggctcactgggcG CATATAAAATAAAAACCAtcttcgtttgaaagatggttttttcatttatgattctcgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-35" downshifts 3856621 /Source="Nicolas_upshifts" /id="D2122" /incds=0 /nref=11 /ntot=30 /MaxReadThrough="2.64888" /MaxDrop="3.74502" /score="0.352922387" /energy="-6.6" /TU="NA" /idTUdmin="U3231" /TUdmin=0 /isTUend="TRUE" /label="downshifts" promotor_-10 3856624..3856642 /Source="Nicolas_upshift_promotors" /id="U3232" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.440559440559441" /psig="0.440559440559441" /xcortree=291 /SigmaFactorBS="gaggcaagaacgccttaacCCGTTGCAAaggctcactgggcG CATATAAAATAAAAACCAtcttcgtttgaaagatggttttttcatttatgattctcgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="promotor_-10" upshifts 3856643 /Source="Nicolas_upshifts" /id="U3232" /multdbtbs="-" /comp="M5" /sig="Sig-" /pcomp="0.440559440559441" /psig="0.440559440559441" /xcortree=291 /SigmaFactorBS="gaggcaagaacgccttaacCCGTTGCAAaggctcactgggcG CATATAAAATAAAAACCAtcttcgtttgaaagatggttttttcatttatgattctcgt t" /GFF_Attribute="listShort" /GFF_Attribute="listLong" /label="upshifts" CDS complement(3856670..3857518) /gene="parB" /locus_tag="BSU_40960" /old_locus_tag="BSU40960" /function="16.9: Replicate" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11532141, 12950914, 15659156, 15774898, 15998739, 16677298, 21235642, 28407103" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11532141, 12950914, 15659156, 15774898, 15998739, 16677298, 21235642, 28407103; Product type f: factor" /codon_start=1 /transl_table=11 /product="site-specific DNA-binding protein" /protein_id="NP_391976.1" /db_xref="EnsemblGenomes-Gn:BSU40960" /db_xref="EnsemblGenomes-Tr:CAB16133" /db_xref="GOA:P26497" /db_xref="InterPro:IPR003115" /db_xref="InterPro:IPR004437" /db_xref="InterPro:IPR036086" /db_xref="SubtiList:BG10054" /db_xref="UniProtKB/Swiss-Prot:P26497" /translation="MAKGLGKGINALFNQVDLSEETVEEIKIADLRPNPYQPRKHFDD EALAELKESVLQHGILQPLIVRKSLKGYDIVAGERRFRAAKLAGLDTVPAIVRELSEA LMREIALLENLQREDLSPLEEAQAYDSLLKHLDLTQEQLAKRLGKSRPHIANHLRLLT LPENIQQLIAEGTLSMGHGRTLLGLKNKNKLEPLVQKVIAEQLNVRQLEQLIQQLNQN VPRETKKKEPVKDAVLKERESYLQNYFGTTVNIKRQKKKGKIEIEFFSNEDLDRILEL LSERES*" /label="parB CDS" gene complement(3856670..3857518) /gene="parB" /locus_tag="BSU_40960" /old_locus_tag="BSU40960" /label="parB gene" downshifts complement(3856690) /Source="Nicolas_upshifts" /id="D2123" /incds=0 /nref=208 /ntot=265 /MaxReadThrough="3.01094" /MaxDrop="5.3801" /score="9.82080496" /energy="-7.9" /TU="U3233" /idTUdmin="U3233" /TUdmin="-257" /isTUend="FALSE" /label="downshifts" CDS complement(3857511..3858272) /gene="parA" /locus_tag="BSU_40970" /old_locus_tag="BSU40970" /function="16.13: Shape" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:11532141, 12950914, 15659156, 15774898, 15998739, 16677298, 18077387, 28166228" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11532141, 12950914, 15659156, 15774898, 15998739, 16677298, 18077387, 28166228; Product type f: factor" /codon_start=1 /transl_table=11 /product="chromosome partitioning protein; transcriptionalregulator" /protein_id="NP_391977.1" /db_xref="EnsemblGenomes-Gn:BSU40970" /db_xref="EnsemblGenomes-Tr:CAB16134" /db_xref="GOA:P37522" /db_xref="InterPro:IPR025669" /db_xref="InterPro:IPR027417" /db_xref="SubtiList:BG10055" /db_xref="UniProtKB/Swiss-Prot:P37522" /translation="MGKIIAITNQKGGVGKTTTSVNLGACLAYIGKRVLLVDIDPQGN ATSGLGIEKADVEQCVYDILVDDADVIDIIKATTVENLDVIPATIQLAGAEIELVPTI SREVRLKRALEAVKQNYDYIIIDCPPSLGLLTINALTASDSVVIPVQCEYYALEGLSQ LLNTVRLVQKHLNTDLMIEGVLLTMLDARTNLGIQVIEEVKKYFRDKVYKTVIPRNVR LSEAPSHGKPIILYDPRSRGAEVYLDLAKEVAANG*" /label="parA CDS" gene complement(3857511..3858272) /gene="parA" /locus_tag="BSU_40970" /old_locus_tag="BSU40970" /label="parA gene" misc_feature complement(3858306..3858325) /Source="Nicolas_upshift_promotors" /id="U3233" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.663336663336663" /psig="0.999000999001" /xcortree=2325 /SigmaFactorBS="attatttcccttctgattcggaacaaaatgatgaaaaaaatg aaacgctttaatcttttTTTGATAGAATAGAAGCAAGatagtacatgttcatgtgaaa g" /listShort="parA, parB" /GFF_Attribute="listLong" /label="promotor_single_box" /note="Geneious type: promotor_single_box" upshifts complement(3858324) /Source="Nicolas_upshifts" /id="U3233" /multdbtbs="-" /comp="M4" /sig="SigA" /pcomp="0.663336663336663" /psig="0.999000999001" /xcortree=2325 /SigmaFactorBS="attatttcccttctgattcggaacaaaatgatgaaaaaaatg aaacgctttaatcttttTTTGATAGAATAGAAGCAAGatagtacatgttcatgtgaaa g" /listShort="parA, parB" /GFF_Attribute="listLong" /label="upshifts" upshifts complement(3858416) /Source="Nicolas_upshifts" /id="U3234" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=1771 /SigmaFactorBS="tttttttctttaagaaattccttttttAAGTCAAAAaaacat agaaattGCAGAATTTataagagaaagcataaagcgtgcttgaattttcaattatttc c" /GFF_Attribute="listShort" /listLong="parA, parB" /label="upshifts" promotor_-10 complement(3858419..3858427) /Source="Nicolas_upshift_promotors" /id="U3234" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=1771 /SigmaFactorBS="tttttttctttaagaaattccttttttAAGTCAAAAaaacat agaaattGCAGAATTTataagagaaagcataaagcgtgcttgaattttcaattatttc c" /GFF_Attribute="listShort" /listLong="parA, parB" /label="promotor_-10" promotor_-35 complement(3858441..3858449) /Source="Nicolas_upshift_promotors" /id="U3234" /multdbtbs="-" /comp="M2" /sig="SigI" /pcomp="0.966033966033966" /psig="0.966033966033966" /xcortree=1771 /SigmaFactorBS="tttttttctttaagaaattccttttttAAGTCAAAAaaacat agaaattGCAGAATTTataagagaaagcataaagcgtgcttgaattttcaattatttc c" /GFF_Attribute="listShort" /listLong="parA, parB" /label="promotor_-35" promotor_-35 3858453..3858461 /Source="Nicolas_upshift_promotors" /id="U3235" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=500 /SigmaFactorBS="tttctcttataaattctgcaatttctatgtttttttgactta aaAAAGGAATTtcttaaagaaaAAAAGAAGAAGTCACAGTAcagaacgtggaaacagg a" /listShort="yyaB" /GFF_Attribute="listLong" /label="promotor_-35" upshifts 3858469 /Source="Nicolas_upshifts" /id="U3235" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=500 /SigmaFactorBS="tttctcttataaattctgcaatttctatgtttttttgactta aaAAAGGAATTtcttaaagaaaAAAAGAAGAAGTCACAGTAcagaacgtggaaacagg a" /listShort="yyaB" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3858473..3858491 /Source="Nicolas_upshift_promotors" /id="U3235" /multdbtbs="-" /comp="M1" /sig="SigH" /pcomp="0.999000999001" /psig="0.999000999001" /xcortree=500 /SigmaFactorBS="tttctcttataaattctgcaatttctatgtttttttgactta aaAAAGGAATTtcttaaagaaaAAAAGAAGAAGTCACAGTAcagaacgtggaaacagg a" /listShort="yyaB" /GFF_Attribute="listLong" /label="promotor_-10" CDS 3858520..3858960 /gene="yyaB" /locus_tag="BSU_40980" /old_locus_tag="BSU40980" /function="16.13: Shape" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 3: Putative function from multiple computational evidences; PubMedId: 15849754, 16850406, 25651892; Product type m: membrane component" /codon_start=1 /transl_table=11 /product="putative antibiotic immunity protein" /protein_id="NP_391978.2" /db_xref="EnsemblGenomes-Gn:BSU40980" /db_xref="EnsemblGenomes-Tr:CAB16135" /db_xref="GOA:P37523" /db_xref="InterPro:IPR009589" /db_xref="SubtiList:BG10056" /db_xref="UniProtKB/Swiss-Prot:P37523" /translation="MVYQTKRDVPVTLMIVFLILLIQADAIVPFVLGNMRVSGWIIFI LLTLLNGLIIWSFIDLKYVLKEHHLIIKAGLIKHQIPYENIDKVVQKKKLWSGFRLIG SRHAITIYYQGGWGHAVISPQKSEEFIHKLKEKNSNIIIFTKSK*" /label="yyaB CDS" gene 3858520..3858960 /gene="yyaB" /locus_tag="BSU_40980" /old_locus_tag="BSU40980" /label="yyaB gene" downshifts 3858909 /Source="Nicolas_upshifts" /id="D2124" /incds=0 /nref=3 /ntot=144 /MaxReadThrough="2.25356" /MaxDrop="3.41185" /score="-0.6683508" /energy="-14.5" /TU="NA" /idTUdmin="U3235" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3859011..3859862) /gene="nocA" /locus_tag="BSU_40990" /old_locus_tag="BSU40990" /function="16.13: Shape" /function="16.8: Protect" /function="16.9: Replicate" /experiment="publication(s) with functional evidences, PMID:11807071, 15210112, 16549676, 25568309, 28500529" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11807071, 15210112, 16549676, 25568309, 28500529; Product type f: factor" /codon_start=1 /transl_table=11 /product="DNA-binding protein Spo0J-like" /protein_id="NP_391979.1" /db_xref="EnsemblGenomes-Gn:BSU40990" /db_xref="EnsemblGenomes-Tr:CAB16136" /db_xref="GOA:P37524" /db_xref="InterPro:IPR003115" /db_xref="InterPro:IPR004437" /db_xref="InterPro:IPR023705" /db_xref="InterPro:IPR036086" /db_xref="SubtiList:BG10057" /db_xref="UniProtKB/Swiss-Prot:P37524" /translation="MKHSFSRFFGLGEKEQEPEIAEHDTNKEEILEIPVNAIVPNRFQ PRTIFSDEKIKELAMTIHTHGIIQPIVVRHTEEEGQYELIAGERRWRAVQSLEWEKIP AIIKDFSDTETASVALIENLQREELSSIEEAHAYARLLELHDLTQEALAQRLGKGQST IANKLRLLKLPQPVQEAIMEKKITERHARALIPLKQPELQVTLLTEIIEKSLNVKQTE DRVVKMLEQGQRKPKPRRKAFSRDTRIAMNTIRQSLSMVEDSGVKLNTEEEEFEEYIQ LTIRIPK*" /label="nocA CDS" gene complement(3859011..3859862) /gene="nocA" /locus_tag="BSU_40990" /old_locus_tag="BSU40990" /label="nocA gene" downshifts complement(3859030) /Source="Nicolas_upshifts" /id="D2125" /incds=0 /nref=245 /ntot=265 /MaxReadThrough="2.30868" /MaxDrop="6.68899" /score="29.5496038" /energy="-14.5" /TU="NA" /idTUdmin="U3236" /TUdmin="-1" /isTUend="TRUE" /label="downshifts" S_feature complement(3859863..3859983) /Source="Nicolas_S_feature" /locus_tag="new_4208749_4208869_c" /HighExp="LBGstat, G135, G180, H2O2, dia15, G150, Paraq, T0.30H, Oxctl, Diami" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1577" CDS complement(3859984..3860703) /gene="rsmG" /locus_tag="BSU_41000" /old_locus_tag="BSU41000" /EC_number="2.1.1.170" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:12001236, 17238915, 17573471, 19622680, 24509311" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 12001236, 17238915, 17573471, 19622680, 24509311; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="7-methylguanosine methyltransferase (16S rRNA, nucleotide G527)" /protein_id="NP_391980.1" /db_xref="EnsemblGenomes-Gn:BSU41000" /db_xref="EnsemblGenomes-Tr:CAB16137" /db_xref="GOA:P25813" /db_xref="InterPro:IPR003682" /db_xref="InterPro:IPR029063" /db_xref="PDB:1XDZ" /db_xref="SubtiList:BG10058" /db_xref="UniProtKB/Swiss-Prot:P25813" /translation="MNIEEFTSGLAEKGISLSPRQLEQFELYYDMLVEWNEKINLTSI TEKKEVYLKHFYDSITAAFYVDFNQVNTICDVGAGAGFPSLPIKICFPHLHVTIVDSL NKRITFLEKLSEALQLENTTFCHDRAETFGQRKDVRESYDIVTARAVARLSVLSELCL PLVKKNGLFVALKAASAEEELNAGKKAITTLGGELENIHSFKLPIEESDRNIMVIRKI KNTPKKYPRKPGTPNKSPIEG*" /label="rsmG CDS" gene complement(3859984..3860703) /gene="rsmG" /locus_tag="BSU_41000" /old_locus_tag="BSU41000" /label="rsmG gene" CDS complement(3860717..3862603) /gene="trmF" /locus_tag="BSU_41010" /old_locus_tag="BSU41010" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 11914360, 14993678, 17062623, 26735940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA uridine 5-carboxymethylaminomethyl modification enzyme" /protein_id="NP_391981.1" /db_xref="EnsemblGenomes-Gn:BSU41010" /db_xref="EnsemblGenomes-Tr:CAB16138" /db_xref="GOA:P25812" /db_xref="InterPro:IPR002218" /db_xref="InterPro:IPR004416" /db_xref="InterPro:IPR020595" /db_xref="InterPro:IPR026904" /db_xref="InterPro:IPR036188" /db_xref="SubtiList:BG10059" /db_xref="UniProtKB/Swiss-Prot:P25812" /translation="MGYEAGQYDVIVIGAGHAGVEAALASARQGAKTLVLTINLDMVA FMPCNPSVGGPAKGIVVREIDALGGEMGRNIDKTHIQMRMLNTGKGPAVRALRAQADK FQYQHEMKNTLEKEPNLTLLQGIVERLIVEDGECRGVITQTGAHYRAKAVVMTTGTYL RGRIILGDLSYSSGPNNQQPSIKLSEHLEELGFDLVRFKTGTPPRVKSDTIDYSKTEI QPGDDVPRAFSYETVEYITDQLPCWLTYTSPETHEIIDSNLHRSPMYSGMIKGTGPRY CPSIEDKVVRFNDKPRHQIFLEPEGRNTQEVYVQGLSTSLPEDVQQRMLATIPGLENV QMMRAGYAIEYDAIVPTQLWPTLETKKITNLYTAGQINGTSGYEEAAGQGIMAGINAG RKALGKEEVILSRSDAYIGVLIDDLVTKGTNEPYRLLTSRAEYRLLLRHDNADLRLTE IGHRIGLISDERYAAFEKKKAAIEAEKKRLHSVIIKPSPENQEYIRSLGGSELKDGVR GTDLMKRPEMNYETVTKLAPPEVPVPQDVAEQVEIQVKYEGYIEKSLQQVEKLKKMEN KKIPDRIDYDAIKGIATEARQKLKNVRPLSVAQASRISGVNPADISILLVYLEQGRIA KIAE*" /label="trmF CDS" gene complement(3860717..3862603) /gene="trmF" /locus_tag="BSU_41010" /old_locus_tag="BSU41010" /label="trmF gene" CDS complement(3862624..3864003) /gene="mnmE" /locus_tag="BSU_41020" /old_locus_tag="BSU41020" /EC_number="3.6.-.-" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 15522079, 15616586, 19052377, 26735940; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="tRNA modification GTPase and tRNA-U34 5-formylation enzyme" /protein_id="NP_391982.1" /db_xref="EnsemblGenomes-Gn:BSU41020" /db_xref="EnsemblGenomes-Tr:CAB16139" /db_xref="GOA:P25811" /db_xref="InterPro:IPR004520" /db_xref="InterPro:IPR005225" /db_xref="InterPro:IPR006073" /db_xref="InterPro:IPR018948" /db_xref="InterPro:IPR025867" /db_xref="InterPro:IPR027368" /db_xref="InterPro:IPR027417" /db_xref="InterPro:IPR031168" /db_xref="SubtiList:BG10060" /db_xref="UniProtKB/Swiss-Prot:P25811" /translation="MDTIAAISTPMGEGAIAIVRLSGPEAIQIADKIYKGPKGKTLSS VESHTIHYGHIVDRPSDRVVEEVMVSVLKAPRTFTREDVIEINCHGGIVTVNQVLQLA LREGARLAEPGEFTKRAFLNGRIDLSQAEAVMDLIRAKTDRAMNVAMNQMEGRLSALV RRLRSEILETLAHVEVNIDYPEYDDVEEMTHQILVEKATAVKKEIETLLRTSEQGKIL REGLSTVIIGRPNVGKSSLLNSLVHEAKAIVTDIPGTTRDVIEEYVNVRGVPLRLVDT AGIRETEDIVERIGVERSRQVLKEADLILLVLNYSEELSEEDVKLFEAVEGMDVIVIL NKTDLEPKIDTERVRELANGRPVVTTSLLKEEGINDLEEAIQSLFYTGAIESGDLTYV SNTRHITILQQAKRAIEDALSGIEQDVPIDMVQIDLTRCWELLGEIIGDSVHESLIDQ LFSQFCLGK*" /label="mnmE CDS" gene complement(3862624..3864003) /gene="mnmE" /locus_tag="BSU_41020" /old_locus_tag="BSU41020" /label="mnmE gene" S_feature complement(3864004..3864134) /Source="Nicolas_S_feature" /locus_tag="new_4212890_4213020_c" /HighExp="dia15, Diami, LBGstat, H2O2, Paraq, dia5, G180, T0.30H, LBGexp, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="SigA" /TUlongPSig=1 /label="S1578" promotor_-10 complement(3864126..3864145) /Source="Nicolas_upshift_promotors" /id="U3236" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.596403596403596" /psig=1 /xcortree=2527 /SigmaFactorBS="gataaaaaggaagttcaggaaataaaattAATTGttattcac atgtggaTAAGTTAAAGTAATAAGGGAcgaatttctatttctgtggataacaaatctt c" /listShort="S1578, trmE, trmF, rsmG, S1577, noc" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3864134) /Source="Nicolas_upshifts" /id="U3236" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.596403596403596" /psig=1 /xcortree=2527 /SigmaFactorBS="gataaaaaggaagttcaggaaataaaattAATTGttattcac atgtggaTAAGTTAAAGTAATAAGGGAcgaatttctatttctgtggataacaaatctt c" /listShort="S1578, trmE, trmF, rsmG, S1577, noc" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3864161..3864165) /Source="Nicolas_upshift_promotors" /id="U3236" /multdbtbs="-" /comp="M16" /sig="SigA" /pcomp="0.596403596403596" /psig=1 /xcortree=2527 /SigmaFactorBS="gataaaaaggaagttcaggaaataaaattAATTGttattcac atgtggaTAAGTTAAAGTAATAAGGGAcgaatttctatttctgtggataacaaatctt c" /listShort="S1578, trmE, trmF, rsmG, S1577, noc" /GFF_Attribute="listLong" /label="promotor_-35" promotor_-10 complement(3864189..3864208) /Source="Nicolas_upshift_promotors" /id="U3237" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=2014 /SigmaFactorBS="tctacttttcctagtaatatcaaggttttgCCGTTTAAgttt tttctttttAGGTGTATCCTGTTGATAAAaaggaagttcaggaaataaaattaattgt t" /GFF_Attribute="listShort" /listLong="S1578, trmE, trmF, rsmG, S1577, noc" /label="promotor_-10" upshifts complement(3864199) /Source="Nicolas_upshifts" /id="U3237" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=2014 /SigmaFactorBS="tctacttttcctagtaatatcaaggttttgCCGTTTAAgttt tttctttttAGGTGTATCCTGTTGATAAAaaggaagttcaggaaataaaattaattgt t" /GFF_Attribute="listShort" /listLong="S1578, trmE, trmF, rsmG, S1577, noc" /label="upshifts" promotor_-35 complement(3864222..3864229) /Source="Nicolas_upshift_promotors" /id="U3237" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.995004995004995" /psig=1 /xcortree=2014 /SigmaFactorBS="tctacttttcctagtaatatcaaggttttgCCGTTTAAgttt tttctttttAGGTGTATCCTGTTGATAAAaaggaagttcaggaaataaaattaattgt t" /GFF_Attribute="listShort" /listLong="S1578, trmE, trmF, rsmG, S1577, noc" /label="promotor_-35" promotor_-35 3864289..3864295 /Source="Nicolas_upshift_promotors" /id="U3238" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.576423576423576" /psig="0.685314685314685" /xcortree=2972 /SigmaFactorBS="atattactaggaaaagtagatttttcggatacaaaaaaaccg aaatccaATTTTTAtcggacttcggtttTATGCTATCTTTTATGGGAAataacgagat g" /listShort="S1579" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3864300..3866585 /Source="Nicolas_S_feature" /locus_tag="new_4213186_4215471" /HighExp="T0.30H, C30, T1.0H, T1.30H, S2, T0.0H, T-1.10H, T-0.40H, T-1.40H, C90" /AntisenseName="oxaAA" /AntisenseCor="-0.20593684080740801" /AntisenseRegPval="-3.2" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig="0.685" /TUlongSig="NA" /TUlongPSig="NA" /label="S1579" upshifts 3864300 /Source="Nicolas_upshifts" /id="U3238" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.576423576423576" /psig="0.685314685314685" /xcortree=2972 /SigmaFactorBS="atattactaggaaaagtagatttttcggatacaaaaaaaccg aaatccaATTTTTAtcggacttcggtttTATGCTATCTTTTATGGGAAataacgagat g" /listShort="S1579" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 3864310..3864329 /Source="Nicolas_upshift_promotors" /id="U3238" /multdbtbs="-" /comp="M19" /sig="SigA" /pcomp="0.576423576423576" /psig="0.685314685314685" /xcortree=2972 /SigmaFactorBS="atattactaggaaaagtagatttttcggatacaaaaaaaccg aaatccaATTTTTAtcggacttcggtttTATGCTATCTTTTATGGGAAataacgagat g" /listShort="S1579" /GFF_Attribute="listLong" /label="promotor_-10" CDS complement(3864314..3864940) /gene="jag" /locus_tag="BSU_41030" /old_locus_tag="BSU41030" /function="16.3: Control" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 1487728, 12813085, 26883633, 27776484; Product type f: factor" /codon_start=1 /transl_table=11 /product="SpoIIIJ-associated RNA/ssDNA-binding protein" /protein_id="NP_391983.1" /db_xref="EnsemblGenomes-Gn:BSU41030" /db_xref="EnsemblGenomes-Tr:CAB16140" /db_xref="GOA:Q01620" /db_xref="InterPro:IPR001374" /db_xref="InterPro:IPR004087" /db_xref="InterPro:IPR015946" /db_xref="InterPro:IPR032782" /db_xref="InterPro:IPR034079" /db_xref="InterPro:IPR036867" /db_xref="SubtiList:BG10061" /db_xref="UniProtKB/Swiss-Prot:Q01620" /translation="MRNVTAAGRNVDEAVQSGLQELGLTKDKVEITVIEEGNKGFLGI FGKKPAIVKLVEKIDPIQQAKLYLQTIAEAIAGKSDVTVQESKKTVRYHITGEKAALL IGKRGQTLNALETLTQLALNRYPGQYKNVTVDAENYRLKRKETLSQLAIKLADQVLKT KKSIQLEPMPSSERKIIHDTLSGYANHQIKTYSMGEGENRHLVISHKR*" /label="jag CDS" gene complement(3864314..3864940) /gene="jag" /locus_tag="BSU_41030" /old_locus_tag="BSU41030" /label="jag gene" downshifts complement(3864331) /Source="Nicolas_upshifts" /id="D2126" /incds=0 /nref=229 /ntot=258 /MaxReadThrough="2.29192" /MaxDrop="6.32351" /score="24.2602773" /energy="-14.1" /TU="NA" /idTUdmin="U3239" /TUdmin=0 /isTUend="TRUE" /label="downshifts" CDS complement(3864937..3865722) /gene="oxaAA" /locus_tag="BSU_41040" /old_locus_tag="BSU41040" /function="16.13: Shape" /experiment="publication(s) with functional evidences, PMID:11889108, 12586834, 15654078, 15671040, 15849754, 15995216, 16850406, 24739968, 25133632, 25313395, 25359772, 25855636" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 11889108, 12586834, 15654078, 15671040, 15849754, 15995216, 16850406, 24739968, 25133632, 25313395, 25359772, 25855636; Product type f: factor" /codon_start=1 /transl_table=11 /product="Sec-independent factor for membrane protein insertion (YidC/SpoIIIJ family)" /protein_id="NP_391984.1" /db_xref="EnsemblGenomes-Gn:BSU41040" /db_xref="EnsemblGenomes-Tr:CAB16141" /db_xref="GOA:Q01625" /db_xref="InterPro:IPR001708" /db_xref="InterPro:IPR023060" /db_xref="InterPro:IPR028055" /db_xref="SubtiList:BG10062" /db_xref="UniProtKB/Swiss-Prot:Q01625" /translation="MLLKRRIGLLLSMVGVFMLLAGCSSVKEPITADSPHFWDKYVVY PLSELITYVAKLTGDNYGLSIILVTILIRLLILPLMIKQLRSSKAMQALQPEMQKLKE KYSSKDQKTQQKLQQETMALFQKHGVNPLAGCFPILIQMPILIGFYHAIMRTQAISEH SFLWFDLGEKDPYYILPIVAGVATFVQQKLMMAGNAQQNPQMAMMLWIMPIMIIVFAI NFPAALSLYWVVGNLFMIAQTFLIKGPDIKKNPEPQKAGGKKK*" /label="oxaAA CDS" gene complement(3864937..3865722) /gene="oxaAA" /locus_tag="BSU_41040" /old_locus_tag="BSU41040" /label="oxaAA gene" promotor_-10 complement(3865767..3865786) /Source="Nicolas_upshift_promotors" /id="U3239" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2262 /SigmaFactorBS="taaaagcgcttcctttctggttgatcagaaaaagaCACCATT taaaactgaaaGATGCTAAAATACATACAAGtatgctttgcaataaaagagtgtaaag a" /listShort="oxaAA, jag" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3865779) /Source="Nicolas_upshifts" /id="U3239" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2262 /SigmaFactorBS="taaaagcgcttcctttctggttgatcagaaaaagaCACCATT taaaactgaaaGATGCTAAAATACATACAAGtatgctttgcaataaaagagtgtaaag a" /listShort="oxaAA, jag" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3865781..3865866) /Source="Nicolas_S_feature" /locus_tag="new_4214667_4214752_c" /HighExp="G135, G180, H2O2, Oxctl, Paraq, G150, Cold, LPh, LBGexp, C30" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.993, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1580" promotor_-35 complement(3865798..3865804) /Source="Nicolas_upshift_promotors" /id="U3239" /multdbtbs="SigA" /comp="M4" /sig="SigA" /pcomp="0.999000999001" /psig=1 /xcortree=2262 /SigmaFactorBS="taaaagcgcttcctttctggttgatcagaaaaagaCACCATT taaaactgaaaGATGCTAAAATACATACAAGtatgctttgcaataaaagagtgtaaag a" /listShort="oxaAA, jag" /GFF_Attribute="listLong" /label="promotor_-35" CDS complement(3865867..3866217) /gene="rnpA" /locus_tag="BSU_41050" /old_locus_tag="BSU41050" /EC_number="3.1.26.5" /function="16.6: Maintain" /function="16.2: Construct biomass (Anabolism)" /inference="ab initio prediction:AMIGene:2.0" /note="Evidence 2a: Function from experimental evidences in other organisms; PubMedId: 12682299, 16061811, 16163391, 16980484, 17299131, 21347352, 24580115; Product type e: enzyme" /codon_start=1 /transl_table=11 /product="protein component of ribonuclease P (RNase P) (substrate specificity)" /protein_id="NP_391985.1" /db_xref="EnsemblGenomes-Gn:BSU41050" /db_xref="EnsemblGenomes-Tr:CAB16142" /db_xref="GOA:P25814" /db_xref="InterPro:IPR000100" /db_xref="InterPro:IPR014721" /db_xref="InterPro:IPR020539" /db_xref="InterPro:IPR020568" /db_xref="PDB:1A6F" /db_xref="PDB:4JG4" /db_xref="SubtiList:BG10063" /db_xref="UniProtKB/Swiss-Prot:P25814" /translation="MKKRNRLKKNEDFQKVFKHGTSVANRQFVLYTLDQPENDELRVG LSVSKKIGNAVMRNRIKRLIRQAFLEEKERLKEKDYIIIARKPASQLTYEETKKSLQH LFRKSSLYKKSSSK*" /label="rnpA CDS" gene complement(3865867..3866217) /gene="rnpA" /locus_tag="BSU_41050" /old_locus_tag="BSU41050" /label="rnpA gene" S_feature complement(3866218..3866368) /Source="Nicolas_S_feature" /locus_tag="new_4215104_4215254_c" /HighExp="G135, G180, Oxctl, H2O2, Paraq, Cold, G150, C30, LPh, HPh" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA, SigA" /TUshortPSig="0.993, 1" /TUlongSig="NA" /TUlongPSig="NA" /label="S1581" CDS complement(3866369..3866503) /gene="rpmH" /locus_tag="BSU_41060" /old_locus_tag="BSU41060" /function="16.2: Construct biomass (Anabolism)" /experiment="publication(s) with functional evidences, PMID:7539334, 9371771, 12682299, 23002217, 25182490" /note="Evidence 1a: Function from experimental evidences in the studied strain; PubMedId: 7539334, 9371771, 12682299, 23002217, 25182490; Product type s: structure" /codon_start=1 /transl_table=11 /product="ribosomal protein L34" /protein_id="NP_391986.1" /db_xref="EnsemblGenomes-Gn:BSU41060" /db_xref="EnsemblGenomes-Tr:CAB16143" /db_xref="GOA:P05647" /db_xref="InterPro:IPR000271" /db_xref="InterPro:IPR020939" /db_xref="PDB:3J3V" /db_xref="PDB:3J3W" /db_xref="PDB:3J9W" /db_xref="PDB:5NJT" /db_xref="SubtiList:BG10064" /db_xref="UniProtKB/Swiss-Prot:P05647" /translation="MKRTFQPNNRKRSKVHGFRSRMSSKNGRLVLARRRRKGRKVLSA *" /label="rpmH CDS" gene complement(3866369..3866503) /gene="rpmH" /locus_tag="BSU_41060" /old_locus_tag="BSU41060" /label="rpmH gene" promotor_no_box 3866527..3866627 /Source="Nicolas_upshift_promotors" /id="U3241" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.467532467532468" /psig="0.047952047952048" /xcortree=1495 /SigmaFactorBS="agctgttaaagacagtcttacttattatatttgcgttaccta ttcattgtcaacttcactagtgcttttatttcttgcaaccataataggataccatacc t" /listShort="S1583" /GFF_Attribute="listLong" /label="promotor_no_box" promotor_-10 complement(3866539..3866558) /Source="Nicolas_upshift_promotors" /id="U3240" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.587412587412587" /psig="0.993006993006993" /xcortree=2640 /SigmaFactorBS="tggttgcaagaaataaaagcactagtgaAGTTGACAatgaat aggtaacgcAAATATAATAAGTAAGACTGtctttaacagctattcctcgagggaggtg t" /listShort="rpmH, S1581, rnpA, S1580, oxaAA, jag" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3866549) /Source="Nicolas_upshifts" /id="U3240" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.587412587412587" /psig="0.993006993006993" /xcortree=2640 /SigmaFactorBS="tggttgcaagaaataaaagcactagtgaAGTTGACAatgaat aggtaacgcAAATATAATAAGTAAGACTGtctttaacagctattcctcgagggaggtg t" /listShort="rpmH, S1581, rnpA, S1580, oxaAA, jag" /GFF_Attribute="listLong" /label="upshifts" S_feature complement(3866551..3866619) /Source="Nicolas_S_feature" /locus_tag="new_4215437_4215505_c" /HighExp="Oxctl, G180, Paraq, H2O2, LBGstat, GM 120, MG-0.2, HPh, G135, G150" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="SigA" /TUshortPSig=1 /TUlongSig="NA" /TUlongPSig="NA" /label="S1582" promotor_-35 complement(3866574..3866581) /Source="Nicolas_upshift_promotors" /id="U3240" /multdbtbs="SigA" /comp="M14" /sig="SigA" /pcomp="0.587412587412587" /psig="0.993006993006993" /xcortree=2640 /SigmaFactorBS="tggttgcaagaaataaaagcactagtgaAGTTGACAatgaat aggtaacgcAAATATAATAAGTAAGACTGtctttaacagctattcctcgagggaggtg t" /listShort="rpmH, S1581, rnpA, S1580, oxaAA, jag" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3866587..>3866720 /Source="Nicolas_S_feature" /locus_tag="new_4215473_4215670" /HighExp="T0.30H, C30, T1.0H, T1.30H, T0.0H, T-0.40H, S2, T-1.10H, Pyr, T-1.40H" /AntisenseName="NA" /AntisenseCor="NA" /AntisenseRegPval="NA" /CDS_PredictionProba="NA" /TUshortSig="Sig-" /TUshortPSig="0.048" /TUlongSig="NA" /TUlongPSig="NA" /label="S1583" upshifts 3866587 /Source="Nicolas_upshifts" /id="U3241" /multdbtbs="-" /comp="M13" /sig="Sig-" /pcomp="0.467532467532468" /psig="0.047952047952048" /xcortree=1495 /SigmaFactorBS="agctgttaaagacagtcttacttattatatttgcgttaccta ttcattgtcaacttcactagtgcttttatttcttgcaaccataataggataccatacc t" /listShort="S1583" /GFF_Attribute="listLong" /label="upshifts" promotor_-10 complement(3866605..3866624) /Source="Nicolas_upshift_promotors" /id="U3242" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=2591 /SigmaFactorBS="cttttttccgtaaaattaaggaatctaaaaaataaGGTTTcg aaagttgaaaaggTATGGTATCCTATTATGGTTgcaagaaataaaagcactagtgaag t" /listShort="S1582, rpmH, S1581, rnpA, S1580, oxaAA, jag" /GFF_Attribute="listLong" /label="promotor_-10" upshifts complement(3866619) /Source="Nicolas_upshifts" /id="U3242" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=2591 /SigmaFactorBS="cttttttccgtaaaattaaggaatctaaaaaataaGGTTTcg aaagttgaaaaggTATGGTATCCTATTATGGTTgcaagaaataaaagcactagtgaag t" /listShort="S1582, rpmH, S1581, rnpA, S1580, oxaAA, jag" /GFF_Attribute="listLong" /label="upshifts" promotor_-35 complement(3866640..3866644) /Source="Nicolas_upshift_promotors" /id="U3242" /multdbtbs="SigA" /comp="M16" /sig="SigA" /pcomp="0.99000999000999" /psig=1 /xcortree=2591 /SigmaFactorBS="cttttttccgtaaaattaaggaatctaaaaaataaGGTTTcg aaagttgaaaaggTATGGTATCCTATTATGGTTgcaagaaataaaagcactagtgaag t" /listShort="S1582, rpmH, S1581, rnpA, S1580, oxaAA, jag" /GFF_Attribute="listLong" /label="promotor_-35" S_feature 3866721..3866868 /locus_tag="new_1_148" /created_by="stephanmichalik" /label="S1" S_feature complement(3866744..3867017) /locus_tag="new_24_297_c" /created_by="stephanmichalik" /label="S2" S_feature 3866870..3867129 /locus_tag="new_150_409" /created_by="stephanmichalik" /label="S3" ORIGIN 1 atggaaaata tattagacct gtggaaccaa gcccttgctc aaatcgaaaa aaagttgagc 61 aaaccgagtt ttgagacttg gatgaagtca accaaagccc actcactgca aggcgataca 121 ttaacaatca cggctcccaa tgaatttgcc agagactggc tggagtccag atacttgcat 181 ctgattgcag atactatata tgaattaacc ggggaagaat tgagcattaa gtttgtcatt 241 cctcaaaatc aagatgttga ggactttatg ccgaaaccgc aagtcaaaaa agcggtcaaa 301 gaagatacat ctgattttcc tcaaaatatg ctcaatccaa aatatacttt tgatactttt 361 gtcatcggat ctggaaaccg atttgcacat gctgcttccc tcgcagtagc ggaagcgccc 421 gcgaaagctt acaacccttt atttatctat gggggcgtcg gcttagggaa aacacactta 481 atgcatgcga tcggccatta tgtaatagat cataatcctt ctgccaaagt ggtttatctg 541 tcttctgaga aatttacaaa cgaattcatc aactctatcc gagataataa agccgtcgac 601 ttccgcaatc gctatcgaaa tgttgatgtg cttttgatag atgatattca atttttagcg 661 gggaaagaac aaacccagga agaatttttc catacattta acacattaca cgaagaaagc 721 aaacaaatcg tcatttcaag tgaccggccg ccaaaggaaa ttccgacact tgaagacaga 781 ttgcgctcac gttttgaatg gggacttatt acagatatca caccgcctga tctagaaacg 841 agaattgcaa ttttaagaaa aaaggccaaa gcagagggcc tcgatattcc gaacgaggtt 901 atgctttaca tcgcgaatca aatcgacagc aatattcggg aactcgaagg agcattaatc 961 agagttgtcg cttattcatc tttaattaat aaagatatta atgctgatct ggccgctgag 1021 gcgttgaaag atattattcc ttcctcaaaa ccgaaagtca ttacgataaa agaaattcag 1081 agggtagtag gccagcaatt taatattaaa ctcgaggatt tcaaagcaaa aaaacggaca 1141 aagtcagtag cttttccgcg tcaaatcgcc atgtacttat caagggaaat gactgattcc 1201 tctcttccta aaatcggtga agagtttgga ggacgtgatc atacgaccgt tattcatgcg 1261 catgaaaaaa tttcaaaact gctggcagat gatgaacagc ttcagcagca tgtaaaagaa 1321 attaaagaac agcttaaata gcaggaccgg ggatcaatcg gggaaagtgt gaataacttt 1381 tcggaagtca tacacagtct gtccacatgt ggataggctg tgtttcctgt ctttttcaca 1441 acttatccac aaatccacag gccctactat tacttctact attttttata aatatatata 1501 ttaatacatt atccgttagg aggataaaaa tgaaattcac gattcaaaaa gatcgtcttg 1561 ttgaaagtgt ccaagatgta ttaaaagcag tttcatccag aaccacgatt cccattctga 1621 ctggtattaa aattgttgca tcagatgatg gagtatcctt tacagggagt gactcagata 1681 tttctattga atccttcatt ccaaaagaag aaggagataa agaaatcgtc actattgaac 1741 agcccggaag catcgtttta caggctcgct tttttagtga aattgtaaaa aaattgccga 1801 tggcaactgt agaaattgaa gtccaaaatc agtatttgac gattatccgt tctggtaaag 1861 ctgaatttaa tctaaacgga ctggatgctg atgaatatcc gcacttgccg cagattgaag 1921 agcatcatgc gattcagatc ccaactgatt tgttaaaaaa tctaatcaga caaacagtat 1981 ttgcagtgtc cacctcagaa acacgcccta tcttgacagg tgtaaactgg aaagtggagc 2041 aaagtgaatt attatgcact gcaacggata gccaccgtct tgcattaaga aaggcgaaac 2101 ttgatattcc agaagacaga tcttataacg tcgtgattcc gggaaaaagt ttaactgaac 2161 tcagcaagat tttagatgac aaccaggaac ttgtagatat cgtcatcaca gaaacccaag 2221 ttctgtttaa agcgaaaaac gtcttgttct tctcacggct tctggacggg aattatccag 2281 acacaaccag cctgattccg caagacagca aaacagaaat cattgtgaac acaaaagaat 2341 tccttcaggc cattgatcgt gcatctcttt tagctagaga gggacgcaac aacgttgtaa 2401 aactgtccgc aaaaccggct gaatccattg aaatttcttc caattcgcca gaaatcggta 2461 aagttgtgga agcaattgtt gcggatcaaa ttgaaggtga ggaattaaat atctctttta 2521 gtccaaaata tatgctggat gcactaaagg tgcttgaagg agcagaaata cgcgtaagct 2581 ttacaggcgc aatgagacct ttcttaattc gcacgccgaa tgatgaaacg attgtacagc 2641 ttatccttcc tgtcagaacc tattaatccg atacactgct gccgacccgt cggcagcttt 2701 tctattcggt atctgctccg acaagttttc cctttcccta attcgttttt ttttagtaca 2761 attagatatt agtgatattt gaaagaggtc gatataatgg caaatccgat ttcaattgat 2821 acagagatga ttacactcgg acaattctta aaattagccg atgtgattca gtctggcggt 2881 atggcgaagt ggtttttaag cgagcatgaa gtgcttgtga acgatgagcc ggacaaccgc 2941 cggggcagaa agctgtatgt tggagatgtg gtagagattg aaggatttgg ttcatttcaa 3001 gtcgtcaatt aaagcgggtg acactgattg tatatccaga acttagaact gacatcttac 3061 cgcaactacg accatgctga acttcaattt gaaaataaag taaatgtgat catcggagaa 3121 aacgcccagg ggaagacaaa cctcatggag gcgatctatg tcttgtccat ggcgaaatcg 3181 caccggacat caaatgacaa agaacttata cggtgggaca aagactatgc taaaatagag 3241 ggaagagtga tgaagcaaaa cggggcgatc ccgatgcagc tcgtcatctc caaaaagggt 3301 aaaaagggca aggtcaatca tattgaacag caaaagctca gccagtatgt cggggccctc 3361 aacaccatta tgttcgcgcc ggaagattta aatcttgtaa agggaagccc tcaagtgaga 3421 aggcggtttc ttgacatgga aatcggacag gtttctcccg tctaccttca tgatctttct 3481 ctttaccaga aaatcctttc ccagcggaat cattttttga aacagctgca aacaagaaaa 3541 caaactgacc ggacgatgct cgatgttctg accgatcagc ttgtagaagt tgcagcaaaa 3601 gtcgtcgtaa aacgcctgca gtttacagca cagctcgaga aatgggcgca gcccatccat 3661 gcaggcatct caagagggct tgaagaactg accctgaaat accatacagc tcttgatgta 3721 tcagatcccc tagatttgtc gaaaatagga gatagctatc aagaagcgtt ttctaaatta 3781 agagaaaaag aaattgagcg tggtgtgacg ctgtcagggc ctcatcgcga tgatgttctt 3841 ttctatgtga acggacgcga tgtgcagacg tatggttctc aaggacagca gcgaacgacg 3901 gcgttgtccc ttaagctggc ggagattgac ctgatccatg aagaaatcgg agaatatccc 3961 attttactat tggatgatgt actgagtgaa ctggatgatt atcgccagtc acacttgctt 4021 catacgatcc aaggccgtgt acaaacgttt gtcacaacga caagcgttga tggcattgat 4081 cacgaaacct tacgtcaagc aggaatgttc cgtgtgcaaa atggtgcgtt agtgaagtga 4141 agaaatgagg tgagcaattg tatattcatt taggtgatga ctttgtggtt tcaacacgag 4201 atattgtcgg catttttgac tttaaagcca acatgtcgcc tattgttgaa gaatttctga 4261 aaaaacagaa acacaaggtg gtgccttccg taaacggcac gcccaaatct atcgtagtca 4321 cggttcagaa tatatattac tctcccttat cttccagcac attaaaaaaa cgtgcgcaat 4381 ttatgtttga aatagattct tagaaatttt ttatcacgaa tatatcgttt agaaaagtgt 4441 aggtgaatga cgtggctatg gaacagcagc aaaacagtta tgatgaaaat cagatacagg 4501 tactagaagg attggaagct gttcgtaaaa gaccggggat gtatatcggt tcgacaaaca 4561 gcaaaggcct tcaccacttg gtatgggaaa ttgtcgacaa tagtattgac gaagccctcg 4621 ccggttattg tacggatatc aatatccaaa tcgaaaaaga caacagtatc acggttgtag 4681 ataatggccg cggtattcca gtcggtattc atgaaaaaat gggccgtcct gcggtagaag 4741 tcattatgac ggtgcttcat gccggaggaa aatttgacgg aagcggctat aaagtatccg 4801 gaggattaca cggtgtaggt gcgtcggtcg taaacgcact atcaacagag cttgatgtga 4861 cggttcaccg tgacggtaaa attcaccgcc aaacctataa acgcggagtt ccggttacag 4921 accttgaaat cattggcgaa acggatcata caggaacgac gacacatttt gtcccggacc 4981 ctgaaatttt ctcagaaaca accgagtatg attacgatct gcttgccaac cgcgtgcgtg 5041 aattagcctt tttaacaaag ggcgtaaaca tcacgattga agataaacgt gaaggacaag 5101 agcgcaaaaa tgaataccat tacgaaggcg gaattaaaag ttatgtagag tatttaaacc 5161 gctctaaaga ggttgtccat gaagagccga tttacattga aggcgaaaag gacggcatta 5221 cggttgaagt ggctttgcaa tacaatgaca gctacacaag caacatttac tcgtttacaa 5281 acaacattaa cacgtacgaa ggcggtaccc atgaagctgg cttcaaaacg ggcctgactc 5341 gtgttatcaa cgattacgcc agaaaaaaag ggcttattaa agaaaatgat ccaaacctaa 5401 gcggagatga cgtaagggaa gggctgacag cgattatttc aatcaaacac cctgatccgc 5461 agtttgaggg ccaaacaaaa acaaagctgg gcaactcaga agcacggacg atcaccgata 5521 cgttattttc tacggcgatg gaaacattta tgctggaaaa tccagatgca gccaaaaaaa 5581 ttgtcgataa aggtttaatg gcggcaagag caagaatggc tgcgaaaaaa gcgcgtgaac 5641 taacacgccg taagagtgct ttggaaattt caaacctgcc cggtaagtta gcggactgct 5701 cttcaaaaga tccgagcatc tccgagttat atatcgtaga gggtgactct gccggaggat 5761 ctgctaaaca aggacgcgac agacatttcc aagccatttt gccgcttaga ggtaaaatcc 5821 taaacgttga aaaggccaga ctggataaaa tcctttctaa caacgaagtt cgctctatga 5881 tcacagcgct cggcacaggt atcggagaag acttcaacct tgagaaagcc cgttaccaca 5941 aagttgtcat tatgacagat gccgatgttg acggcgcgca catcagaaca ctgctgttaa 6001 cgttctttta cagatatatg cgccaaatta tcgaaaatgg ctacgtgtac attgcgcagc 6061 cgccgctcta caaggttcaa caggggaaac gcgttgaata tgcatacaat gacaaggagc 6121 ttgaagagct gttaaaaact cttcctcaaa cgcctaagcc tggactgcag cgttacaaag 6181 gtcttggtga aatgaatgcc acccagctat gggagacaac catggatcct agctccagaa 6241 cacttcttca ggtaactctt gaagatgcaa tggatgcgga tgagactttt gaaatgctta 6301 tgggcgacaa ggtagaaccg cgccgaaact tcatagaagc gaatgcgaga tacgttaaaa 6361 atcttgacat ctaatcataa aaagccttat ttccaataag aaataaggct tttttctgaa 6421 caagatcaga tgcagcgatg cctgcaatac ctatatattc tagcaattta atgtgtataa 6481 tcataagttt attgatataa tggagaatag tgaaatcgta ttgaaggtca taatggacaa 6541 tctactccca catatttcat gtgatacttc agggaggttt tttaatgagt gaacaaaaca 6601 caccacaagt tcgtgaaata aatatcagtc aggaaatgcg tacgtccttc ttggattatg 6661 caatgagcgt tatcgtgtcc cgtgctcttc cggatgttcg tgacggttta aaaccggttc 6721 atagacggat tttgtatgca atgaatgatt taggcatgac aagtgacaag ccttataaaa 6781 aatccgcgcg tatcgttgga gaagttatcg ggaaatacca cccgcacggt gattcagcgg 6841 tatatgaatc catggtcaga atggctcagg atttcaacta ccgttatatg ctcgttgacg 6901 gtcacggaaa cttcggttct gttgacggag actcagcggc ggccatgcgt tatacagaag 6961 cacgaatgtc taaaatctca atggagattc ttcgcgacat cacaaaagac acaatcgatt 7021 accaggataa ctatgacggg tcagaaagag aacctgtcgt tatgccttca aggttcccga 7081 atctgctcgt gaacggtgct gccggcattg cggtaggtat ggcaacaaac attcctccgc 7141 accagctggg agaaatcatt gacggtgtac ttgctgttag tgagaatccg gacattacaa 7201 ttccagagct tatggaagtc attccagggc ctgatttccc gaccgcgggt caaatcttgg 7261 gacgcagcgg tatccggaaa gcatacgaat caggccgagg ctctatcacg atccgggcaa 7321 aagctgagat cgaacaaaca tcttcgggta aagaaagaat tatcgttaca gagttacctt 7381 accaagtaaa taaggcgaaa ttaattgaga aaattgctga tctcgtaagg gacaaaaaga 7441 tagagggtat cacagatctg cgtgatgagt cagatcgtac aggtatgaga attgtcattg 7501 aaatcagacg cgatgccaat gcgaatgtta tcttaaacaa tctgtacaaa caaactgctc 7561 tacaaacatc ttttggcatc aacctgcttg cgcttgttga tggccagccg aaagttttaa 7621 ctcttaagca atgcctggag cattaccttg accatcaaaa agttgtcatt agacgccgta 7681 ctgcttatga attgcgtaaa gcagaagcga gagctcatat cttggaagga ttgagagttg 7741 cactggatca tctcgatgca gttatctccc ttatccgtaa ttctcaaacg gctgaaattg 7801 cgagaacagg tttaattgaa caattctcac tgacagagaa gcaagcacaa gcgatccttg 7861 acatgaggct ccagcgttta acgggactgg aacgtgaaaa gatcgaagaa gaataccagt 7921 ctcttgttaa attaattgca gagctaaaag acatcttggc aaatgaatat aaagtgcttg 7981 agatcattcg tgaagaactc acggaaatca aagagcgttt taacgatgaa agacgtactg 8041 agatcgtcac ttctggactg gagacaattg aagatgaaga tctcatcgag agagaaaata 8101 tcgtagttac tctgacgcac aacggatacg tcaaacgtct tcctgcatca acttaccgca 8161 gtcaaaaacg gggcggaaaa ggtgtacaag gtatgggaac aaacgaagat gatttcgttg 8221 aacatttgat ctctacgtca actcatgaca cgattctctt cttctcgaac aaggggaaag 8281 tgtatcgtgc aaaagggtat gaaatccctg aatacggcag aacggcaaaa ggaatcccga 8341 ttattaacct gctggaggta gaaaagggtg agtggatcaa cgcgattatt ccagtcacgg 8401 aattcaatgc ggagctttac ctcttcttca ctacaaagca tggggtttca aaacgaacat 8461 cgctatctca attcgctaat atccgcaaca atggtctaat tgctctgagt cttcgtgaag 8521 atgatgaact gatgggtgta cgtctgactg acggcacaaa acaaatcatc attggaacga 8581 aaaacggttt actgattcgt ttccctgaaa cagatgtccg agagatggga agaactgcgg 8641 cgggcgtaaa aggcatcacc ctgacggatg acgacgttgt tgtcggcatg gagattttag 8701 aggaagaatc acacgtcctt atcgtaactg aaaaagggta cggaaaacga actcctgctg 8761 aagagtacag aacccaaagc cggggcggaa aaggactcaa aacagcgaaa atcaccgaga 8821 acaacggcca actagtagca gtgaaagcta ctaaaggtga agaggatcta atgattatta 8881 cagctagcgg cgtactcatc agaatggaca tcaatgatat ctccatcacc ggacgtgtca 8941 ctcaaggtgt gcgtctcatc agaatggcag aagaagagca tgttgctaca gtagctttag 9001 ttgagaaaaa cgaagaagat gagaatgaag aagaacaaga agaagtgtga aaaaaagcgc 9061 agctgaaata gctgcgcttt tttgtgtcat aaccctttac agtcataaaa attatggtat 9121 aatcatttct gttgtctttt taaagacaca agcatgacca ttatgactag taaaaacttt 9181 ttcaaaaaag tattgaccta gttaactaaa aatgttacta ttaagtagtc gctttgagag 9241 aagcacacaa agttctttga aaactaaaca agacaaaacg tacctgttaa ttcattttta 9301 taaatcgcac agcgatgtgc gtagtcagtc aaactagggc ctgcacgacg caggtcacac 9361 aggtgtcgcc gcaggatgcg gtgaacttaa cctgtgatcc atttatcgga gagtttgatc 9421 ctggctcagg acgaacgctg gcggcgtgcc taatacatgc aagtcgagcg gacagatggg 9481 agcttgctcc ctgatgttag cggcggacgg gtgagtaaca cgtgggtaac ctgcctgtaa 9541 gactgggata actccgggaa accggggcta ataccggatg gttgtttgaa ccgcatggtt 9601 caaacataaa aggtggcttc ggctaccact tacagatgga cccgcggcgc attagctagt 9661 tggtgaggta acggctcacc aaggcgacga tgcgtagccg acctgagagg gtgatcggcc 9721 acactgggac tgagacacgg cccagactcc tacgggaggc agcagtaggg aatcttccgc 9781 aatggacgaa agtctgacgg agcaacgccg cgtgagtgat gaaggttttc ggatcgtaaa 9841 gctctgttgt tagggaagaa caagtgccgt tcgaataggg cggtaccttg acggtaccta 9901 accagaaagc cacggctaac tacgtgccag cagccgcggt aatacgtagg tggcaagcgt 9961 tgtccggaat tattgggcgt aaagggctcg caggcggttt cttaagtctg atgtgaaagc 10021 ccccggctca accggggagg gtcattggaa actggggaac ttgagtgcag aagaggagag 10081 tggaattcca cgtgtagcgg tgaaatgcgt agagatgtgg aggaacacca gtggcgaagg 10141 cgactctctg gtctgtaact gacgctgagg agcgaaagcg tggggagcga acaggattag 10201 ataccctggt agtccacgcc gtaaacgatg agtgctaagt gttagggggt ttccgcccct 10261 tagtgctgca gctaacgcat taagcactcc gcctggggag tacggtcgca agactgaaac 10321 tcaaaggaat tgacgggggc ccgcacaagc ggtggagcat gtggtttaat tcgaagcaac 10381 gcgaagaacc ttaccaggtc ttgacatcct ctgacaatcc tagagatagg acgtcccctt 10441 cgggggcaga gtgacaggtg gtgcatggtt gtcgtcagct cgtgtcgtga gatgttgggt 10501 taagtcccgc aacgagcgca acccttgatc ttagttgcca gcattcagtt gggcactcta 10561 aggtgactgc cggtgacaaa ccggaggaag gtggggatga cgtcaaatca tcatgcccct 10621 tatgacctgg gctacacacg tgctacaatg gacagaacaa agggcagcga aaccgcgagg 10681 ttaagccaat cccacaaatc tgttctcagt tcggatcgca gtctgcaact cgactgcgtg 10741 aagctggaat cgctagtaat cgcggatcag catgccgcgg tgaatacgtt cccgggcctt 10801 gtacacaccg cccgtcacac cacgagagtt tgtaacaccc gaagtcggtg aggtaacctt 10861 ttaggagcca gccgccgaag gtgggacaga tgattggggt gaagtcgtaa caaggtagcc 10921 gtatcggaag gtgcggctgg atcacctcct ttctaaggat attttacgga atataagacc 10981 ttgggtctta taaacagaac gttccctgtc ttgtttagtt ttgaaggaac tttgttcctt 11041 gaataagtta agatgggcct gtagctcagc tggttagagc gcacgcctga taagcgtgag 11101 gtcggtggtt cgagtccact caggcccacc atcttatata acggggcctt agctcagctg 11161 ggagagcgcc tgctttgcac gcaggaggtc agcggttcga tcccgctagg ctccaccaac 11221 gtgttctttg aaaactagat aacagtagac atcacattca attagtaaca caagatatca 11281 catagtgatt ctttttaacg gttaagttag aaagggcgca cggtggatgc cttggcacta 11341 ggagccgatg aaggacggga cgaacaccga tatgcttcgg ggagctgtaa gcaagctttg 11401 atccggagat ttccgaatgg ggaaacccac cactcgtaat ggagtggtat ccatatctga 11461 attcatagga tatgagaagg cagacccggg gaactgaaac atctaagtac ccggaggaag 11521 agaaagcaaa tgcgattccc tgagtagcgg cgagcgaaac gggatcagcc caaaccaaga 11581 ggcttgcctc ttggggttgt aggacactct gtacggagtt acaaaggaac gaggtagatg 11641 aagaggtctg gaaaggcccg ccataggagg taacagccct gtagtcaaaa cttcgttctc 11701 tcctgagtgg atcctgagta cggcggaaca cgtgaaattc cgtcggaatc cgggaggacc 11761 atctcccaag gctaaatact ccctagtgac cgatagtgaa ccagtaccgt gagggaaagg 11821 tgaaaagcac cccggaaggg gagtgaaaga gatcctgaaa ccgtgtgcct acaagtagtc 11881 agagcccgtt aacgggtgat ggcgtgcctt ttgtagaatg aaccggcgag ttacgatctc 11941 gtgcaaggtt aagcagaaga tgcggagccg cagcgaaagc gagtctgaat agggcgcatg 12001 agtacgtggt cgtagacccg aaaccaggtg atctacccat gtccagggtg aagttcaggt 12061 aacactgaat ggaggcccga acccacgcac gttgaaaagt gcggggatga ggtgtgggta 12121 ggggtgaaat gccaatcgaa cctggagata gctggttctc tccgaaatag ctttagggct 12181 agcctcaagg taagagtctt ggaggtagag cactgattgg actaggggcc cctaccgggt 12241 taccgaattc agtcaaactc cgaatgccaa tgacttatcc ttgggagtca gactgcgagt 12301 gataagatcc gtagtcgaaa gggaaacagc ccagaccgcc agctaaggtc ccaaagtata 12361 cgttaagtgg aaaaggatgt ggagttgctt agacaaccag gatgttggct tagaagcagc 12421 caccatttaa agagtgcgta atagctcact ggtcgagtga ctctgcgccg aaaatgtacc 12481 ggggctaaac gtatcaccga agctgcggac tgttcttcga acagtggtag gagagcgttc 12541 taagggctgt gaagccagac cggaaggact ggtggagcgc ttagaagtga gaatgccggt 12601 atgagtagcg aaagaggggt gagaatcccc tccaccgaat gcctaaggtt tcctgaggaa 12661 ggctcgtccg ctcagggtta gtcgggacct aagccgaggc cgaaaggcgt aggcgatgga 12721 caacaggttg atattcctgt accacctcct caccatttga gcaatggggg gacgcaggag 12781 gatagggtaa gcgcggtatt ggatatccgc gtccaagcag ttaggctggg aaataggcaa 12841 atccgtttcc cataaggctg agctgtgatg gcgagcgaaa tatagtagcg aagttcctga 12901 ttccacactg ccaagaaaag cctctagcga ggtgagaggt gcccgtaccg caaaccgaca 12961 caggtaggcg aggagagaat cctaaggtga tcgagagaac tctcgttaag gaactcggca 13021 aaatgacccc gtaacttcgg gagaaggggt gctctgttag ggtgcaagcc cgagagagcc 13081 gcagtgaata ggcccaggcg actgtttagc aaaaacacag gtctctgcga agccgtaagg 13141 cgaagtatag gggctgacgc ctgcccggtg ctggaaggtt aagaggagcg cttagcgtaa 13201 gcgaaggtgc gaattgaagc cccagtaaac ggcggccgta actataacgg tcctaaggta 13261 gcgaaattcc ttgtcgggta agttccgacc cgcacgaaag gcgcaacgat ctgggcactg 13321 tctcaacgag agactcggtg aaattatagt acctgtgaag atgcaggtta cccgcgacag 13381 gacggaaaga ccccgtggag ctttactgca gcctgatatt gaatgttggt acagcttgta 13441 caggataggt aggagccttg gaaaccggag cgccagcttc ggtggaggca tcggtgggat 13501 actaccctgg ctgtattgac cttctaaccc gccgccctta tcgggcgggg agacagtgtc 13561 aggtgggcag tttgactggg gcggtcgcct cctaaaaggt aacggaggcg cccaaaggtt 13621 ccctcagaat ggttggaaat cattcgcaga gtgtaaaggc acaagggagc ttgactgcga 13681 gacctacaag tcgagcaggg acgaaagtcg ggcttagtga tccggtggtt ccgcatggaa 13741 gggccatcgc tcaacggata aaagctaccc cggggataac aggcttatct cccccaagag 13801 tccacatcga cggggaggtt tggcacctcg atgtcggctc atcgcatcct ggggctgtag 13861 tcggtcccaa gggttgggct gttcgcccat taaagcggta cgcgagctgg gttcagaacg 13921 tcgtgagaca gttcggtccc tatccgtcgc gggcgcagga aatttgagag gagctgtcct 13981 tagtacgaga ggaccgggat ggacgcaccg ctggtgtacc agttgttctg ccaagggcat 14041 cgctgggtag ctatgtgcgg acgggataag tgctgaaagc atctaagcat gaagcccccc 14101 tcaagatgag atttcccatt ccgcaaggaa gtaagatccc tgaaagatga tcaggttgat 14161 aggtctgagg tggaagtgtg gcgacacatg gagctgacag atactaatcg atcgaggact 14221 taaccatatt tttgaatgat gtcacacctg ttatctagtt ttgagagaac actctcaatt 14281 tgtttggtgg cgatagcgaa gaggtcacac ccgttcccat accgaacacg gaagttaagc 14341 tcttcagcgc cgatggtagt cgggggtttc cccctgtgag agtaggacgc cgccaagcaa 14401 gcttaaaccc agctcaatga gctgggtttt ttgtttgtta aaaatgaaga agaaactgtg 14461 aagcgtattt agggaatttc ttttctgata ctaataaaaa ctgctgaatt aacacgtagt 14521 catcacttat atgctgtgtt aataactcat accaccattc tgtttcatac cttgcaatca 14581 tcccaacgtt gtacaaaatc aaataatgaa ttgtcatttc gggaagcctc agaaattgct 14641 ccctttgaga agggatataa tattggttct tttccatgtc aaacaataag ctggtcgatg 14701 tccatggctc cttgtcttgt ggtgaaattt cgaacagcag cccgtgttca tttttttttg 14761 taaaagacca ttgataatga tgggacatgt attcagcaaa ccttgaatca gacattttgt 14821 aattgattac tacttcctcc ggtacaaaaa tttcgttctt atccttctca acttttgtca 14881 taaatcgttc tttctgctga aagtagaaaa tatcgctaag ttctggaatg gccattaata 14941 attttttcat ggtataccgt tcatctacta tatccgattg tccgaataaa tgtttcataa 15001 aatgtacgca taggccattc cgttgtattt tcacttcatc gtcgctaaaa caataatttt 15061 gtttctttcg ttttcttgtt gttacgccat gtgccagtac tgatgtatgg cttggataat 15121 gaggatcacg tgtaattaag catgctttga taagctgtgc cattccataa aataaaagaa 15181 tcggtttgat ttctaaggga gaatatgcgg cttgtttata aaacgattcg gcatgcttta 15241 agaaataaat aaaccgttca ctgtttttaa aagagttttt tttcgcatcg ttaataccgt 15301 ttaagatata aaccttttct agaaatttct gggttgattc aacggagtaa aatagcgcta 15361 agtctttcca ctcatgatat gtcatgtata tttcttaatc ctttccgtta tctaaatatt 15421 tcaactcttt cccgcttcct tgacatgctc ttggctagtt gataatctac atataatatt 15481 ttgccgaaaa gagggggatt tactaatgtg ggaaagtaaa ttttcaaaag aaggcttaac 15541 gttcgacgat gtgctgcttg taccagcaaa gtctgaggta cttccgcgtg atgtggattt 15601 atctgtagaa cttacaaaaa cgttaaagct aaatattcct gtcatcagcg caggtatgga 15661 cactgtaaca gaatcagcaa tggcaattgc aatggcaaga cagggcggct tgggcatcat 15721 tcacaaaaat atgtccattg aacagcaggc tgaacaagtt gataaagtaa agcgttctga 15781 gcgcggcgtt atcacaaatc ccttcttttt aactcctgat caccaagtat ttgatgcgga 15841 gcatttgatg gggaaataca gaatttccgg tgttccgatt gtaaataacg aagaagacca 15901 gaagcttgtt ggaattatta caaaccgtga ccttcgtttt atttctgact actcaatgaa 15961 aatcagcgac gtcatgacga aagaagagct agttactgca tctgtaggaa ctactctgga 16021 tgaagctgaa aagattttgc agaaacataa aattgaaaag cttcctctcg tagatgacca 16081 gaataaatta aaaggtctta tcacaattaa agacattgaa aaagtcattg agttcccgaa 16141 ctcatctaaa gacattcacg gccgcctgat cgttggcgcg gcagttggtg taactggcga 16201 tacaatgact cgcgtcaaaa agcttgttga agccaatgtt gatgtgattg ttatcgatac 16261 agctcacgga cactctcaag gcgttttaaa cacagtcaca aaaatccgtg aaacgtatcc 16321 cgaattaaac attattgctg gaaacgtggc aacagctgaa gcgacaagag cgcttatcga 16381 agctggagca gacgttgtca aagttggaat agggcctggt tcaatttgta ctacacgtgt 16441 tgtagccggc gtgggtgttc cgcaaattac agcaatttat gattgtgcga ctgaagcaag 16501 aaaacacggc aaaacaatca tcgccgacgg tgggattaaa ttctctggcg atatcactaa 16561 agcattggca gccggcggac atgctgttat gctcggaagc ttgcttgcag gcacatcaga 16621 aagccctggt gaaactgaaa tctaccaagg cagaagattt aaggtatacc gcggcatggg 16681 atcagttgct gcaatggaaa aaggaagtaa agaccgttac ttccaagaag aaaacaaaaa 16741 atttgttcct gaaggaattg aaggacgcac accttacaaa gggccagttg aagaaaccgt 16801 ttatcagcta gtcggaggcc ttcgttctgg tatggggtat tgcgggtcca aagatctgcg 16861 tgcgctaaga gaagaagctc agttcattcg catgactggc gcaggacttc gcgaaagcca 16921 tccgcatgac gtacagatta caaaagaatc acctaactat acaatttcat aataaattgt 16981 tacaaattaa aaacatttga cagggtctct gactctgtct atttttttta tactgattat 17041 gataaaattt atactgttgt gcattgaaaa tgtccttaac ggcttaatta tagatgaaga 17101 aaatgaaata cggaggtcgt acgattgaac atcaagaaat gtaaacagct actgatgtca 17161 ttggttgtgt taactctagc tgtcacgtgt ctggctccaa tgtcaaaagc gaaagcagcc 17221 agcgatccaa ttgatatcaa tgcatctgct gctattatga tcgaagcttc ttcaggtaaa 17281 attctttaca gtaaaaatgc agataagaga ctgccaattg cgagtatgac aaaaatgatg 17341 acagagtatc tgttattgga agcaattgat caaggtaaag tgaaatggga ccaaacctat 17401 acgcctgatg actatgtgta tgaaatttcc caagataaca gcttatcaaa cgttcctctt 17461 cggaaagacg ggaaatacac agtaaaagaa ttatatcaag ctacagcaat ttattctgca 17521 aatgctgctg ctattgcgat tgcagaaatc gttgccggtt ctgaaactaa gtttgttgaa 17581 aaaatgaatg caaaagcaaa agaactaggc ttaacagatt acaaatttgt taacgcaaca 17641 ggtcttgaaa acaaagatct tcacgggcat cagcctgagg ggacaagcgt aaatgaagaa 17701 agtgaagttt ctgcaaagga tatggcggtt cttgcggatc acttgattac tgactaccct 17761 gagatactgg agacttccag tatcgccaaa acgaaattca gagaaggcac cgatgatgaa 17821 atggacatgc cgaactggaa ttttatgctg aaggggcttg tcagcgagta taaaaaagcg 17881 actgtagacg gactgaaaac aggttctact gactctgcgg gttcatgctt tacaggaaca 17941 gctgaacgca acggtatgcg tgtcatcact gttgttttaa acgcaaaggg caaccttcat 18001 acaggccgtt tcgatgaaac gaaaaaaatg tttgattatg ctttcgacaa tttctccatg 18061 aaagaaattt atgctgaagg cgatcaagta aaaggccata aaacaatttc agttgataag 18121 ggtaaagaga aagaagtagg cattgtgaca aacaaggcgt tctctcttcc tgtcaaaaat 18181 ggtgaagaaa agaattacaa agcgaaggtc acactgaata aagacaactt aactgctcct 18241 gtgaaaaaag gaaccaaggt tgggaagctg actgcggaat acacaggtga tgaaaaggat 18301 tacggattcc ttaacagcga tctggctggc gtagaccttg ttacaaaaga aaatgtagaa 18361 aaagcaaact ggtttgtttt gacaatgcgc agtatcggcg gattttttgc cggaatttgg 18421 ggaagcattg ttgatacggt aaccggctgg ttttaatcaa ttgaaagagc tctgatggat 18481 gttagggctc tttcgcgtaa tatactgaaa aaacccaatt tttaataaaa aatgattttc 18541 aaagcgctaa aaaccgaata aaatagtata tatgcatatg aattattgga tttctaggat 18601 acaataagga ttagaaatca tataactata ccttgattag ggggaccaag aaatggctca 18661 aacaggtact gaacgtgtaa aacgcggaat ggcagaaatg caaaaaggcg gcgtcatcat 18721 ggacgtcatc aatgcggaac aagcgaaaat cgctgaagaa gctggagctg tcgctgtaat 18781 ggcgctagaa cgtgtgccag cagatattcg cgcggctgga ggagttgccc gtatggctga 18841 ccctacaatc gtggaagaag taatgaatgc agtatctatc ccggtaatgg caaaagcgcg 18901 tatcggacat attgttgaag cgcgtgtgct tgaagctatg ggtgttgact atattgatga 18961 aagtgaagtt ctgacgccgg ctgacgaaga atttcattta aataaaaatg aatacacagt 19021 tccttttgtc tgtggctgcc gtgatcttgg tgaagcaaca cgccgtattg cggaaggtgc 19081 ttctatgctt cgcacaaaag gtgagcctgg aacaggtaat attgttgagg ctgttcgcca 19141 tatgcgtaaa gttaacgctc aagtgcgcaa agtagttgcg atgagtgagg atgagctaat 19201 gacagaagcg aaaaacctag gtgctcctta cgagcttctt cttcaaatta aaaaagacgg 19261 caagcttcct gtcgttaact ttgccgctgg cggcgtagca actccagctg atgctgctct 19321 catgatgcag cttggtgctg acggagtatt tgttggttct ggtattttta aatcagacaa 19381 ccctgctaaa tttgcgaaag caattgtgga agcaacaact cactttactg attacaaatt 19441 aatcgctgag ttgtcaaaag agcttggtac tgcaatgaaa gggattgaaa tctcaaactt 19501 acttccagaa cagcgtatgc aagaacgcgg ctggtaagaa cataggagcg ctgctgacat 19561 gttaacaata ggtgtactag gacttcaagg agcagttaga gagcacatcc atgcgattga 19621 agcatgcggc gcggctggtc ttgtcgtaaa acgtccggag cagctgaacg aagttgacgg 19681 gttgattttg ccgggcggtg agagcacgac gatgcgccgt ttgatcgata cgtatcaatt 19741 catggagccg cttcgtgaat tcgctgctca gggcaaaccg atgtttggaa catgtgccgg 19801 attaattata ttagcaaaag aaattgccgg ttcagataat cctcatttag gtcttctgaa 19861 tgtggttgta gaacgtaatt catttggccg gcaggttgac agctttgaag ctgatttaac 19921 aattaaaggc ttggacgagc cttttactgg ggtattcatc cgtgctccgc atattttaga 19981 agctggtgaa aatgttgaag ttctatcgga gcataatggt cgtattgtag ccgcgaaaca 20041 ggggcaattc cttggctgct cattccatcc ggagctgaca gaagatcacc gagtgacgca 20101 gctgtttgtt gaaatggttg aggaatataa gcaaaaggca cttgtataaa acagttgaaa 20161 gctgtggaaa cttatagtac attataagca caaataaaga tcgaaaagcg ttgataggaa 20221 ctagtaggga gcctctcttt ctaagagagc cgatggttgg tgcgaatcgg tgaaagatgc 20281 tgtctgaatc catccttgag cgaaatgctg aagcgagtag gcatttacgg gataaccgtt 20341 atgtttgaaa gtggaaaacg agtctttgat ttgttttcaa tcagggtggc aacgcgagag 20401 ctctcgtccc tttatgggga tgagggctct ttttattttc gataaatcaa taaaaaaagg 20461 agtgtttcgc atgcttgata cgaaaatgct gagagcaaat tttcaagaaa ttaaagcaaa 20521 gcttgtacac aaaggcgaag acttaactga ttttgataag tttgaggcgc tggatgatag 20581 acgaagagag cttatcggca aggttgaaga gttaaaagga aaacgaaatg aagtttctca 20641 gcaggttgct gtgctgaagc gtgagaaaaa agacgcggat cacattatta aagaaatgcg 20701 tgaagtcggc gaggaaatta aaaagctcga tgaagaatta cggacagtgg aagctgagct 20761 tgatacaatc ctgctctcaa tcccgaatat tccgcatgag tctgtacctg tcggtgaaac 20821 agaagacgac aacgtagaag tgcgtaaatg gggtgaaaag ccttcatttg cttatgagcc 20881 gaagccgcac tgggatattg cggatgagct gggtattctg gattttgaac gtgctgccaa 20941 agtaacagga agccgtttcg tgttctataa aggcttaggt gctcgtctgg agcgtgcgct 21001 ttataacttt atgcttgatc tgcatgtgga tgagtataac tacactgaag tgatcccgcc 21061 atatatggta aaccgcgcaa gcatgacggg aacggggcag cttcctaaat ttgaagagga 21121 tgcatttaaa atcagagaag aagattattt cttaattcca acggcggaag tgccgattac 21181 aaacatgcat cgcgatgaaa tcctttcagg tgacagcctg ccgatcaact atgcggcatt 21241 cagtgcttgc ttccgttctg aagctggttc agcaggacgt gacacacgcg gattaattcg 21301 tcagcaccaa tttaataaag ttgagcttgt aaagtttgtg aagcctgaag attcttatga 21361 agaattagag aaacttacaa accaagcaga acgggttctt cagctgcttg agcttccata 21421 ccgtgtcatg agcatgtgta cgggtgactt aggctttacg gctgcgaaaa aatacgatat 21481 cgaagtttgg attccaagcc aagacacata tcgagaaatc tcttcttgca gcaacttcga 21541 agcgttccag gcgagacgtg cgaatattcg tttcagacgt gaagcgaaag gcaagcctga 21601 gcatgtacac acactgaacg gctcaggact ggcggttgga agaacagttg ctgctatctt 21661 agaaaattat cagcaggaag acggaagcgt tgtgattccg aaagtgcttc gtccttatat 21721 ggggaataga gaagtaatga aaccgtaaat tatggaaagg cgtgcctgac aaggtgcgcc 21781 tttttgctta tgtaaacacg gcattttcat aaaaacaaaa aaagttttta aaaatgcttg 21841 accacacgag aacatacgtg atatagttag tcttgtcgat acggaggaat acccaagtcc 21901 ggctgaaggg atcggtcttg aaaaccgaca ggggtgtcaa agcccgcggg ggttcgaatc 21961 cctcttcctc cgccatattg attttaattc taatgaaaca caagcatata ttggagattg 22021 ttttgtccgt tgcattcggt gcggcggatt ttttatttta aagaaaaagt gaatctcgac 22081 tgagattcac tttttttgat tatcatgaat aactgaagca atttgatcta caatattttc 22141 aatcgagttt tcgtcgttca gaagatcata atcttcaatg cgaagtttta aaacagggca 22201 ggcattaaaa ccgcttatcc agttctcgta gcgtgtatgc atttcttccc aataagaccg 22261 gcttgtctga agctccatct cacggccgcg ttgttcaatc cggtttaaaa tgttctccag 22321 atctccttct aaatagatca acacatctgg atgtgggaaa tacggtgtca ttaccattgc 22381 ttcgaaaagg cttgtgtaag tcttataatc aacctttgac attgtccctt tatcagcatg 22441 catttttgcg aaaattcctg tatcttcata aatcgaacga tcctgtacaa aacctccgcc 22501 ggcttcaaaa attgttttct gttctttgaa gcgttcagct aagaagtaaa tttgaaggtg 22561 aaagctccaa cgttcaaaat catgatagaa cttttccaaa tatggattat gatcgacttc 22621 ctccaacgat gttttaaatc caagccgttt agctaaagtt tttgttaaag tcgattttcc 22681 gacacctact gttcctgcta ctgtaataat tgaattctta gggatatgat gttccttcat 22741 acgataagct cctttacatg ggcggcaatg cgttcaaagt cgctcttatt caaaacgaaa 22801 tcctttgaat caccatctac ggttaacact gtaagttcag ggtctgcttc ctgcagctgc 22861 ttgatggcga cttcataatc tgaaatcagc tgctccaaat agctagtttc aatttttttc 22921 tcaaaggggc gcccgcgttt ttcaatgcgg tgtagcaatg taggcagact ggcctttatg 22981 taaatgatga aattcggctt tggcagatca tccgttagca ggtgatatat ctttttgtat 23041 ttttccagct gatgtggaga caaggttcgt tccgcaaaaa tcacattttt ataaatatga 23101 taatcagcta ttacaggctg tccctttttt aaaaagtgat cactggtgtc ttcaagctgt 23161 ttgtatctgt gacaaagaaa aaacatctcg agctggaagc tccattcctt tatattgtca 23221 taaaacttat caaggtacgg gttatcctct acaatctcat tgatcatagg gaatccgaat 23281 ttttgtgaga gcatcgttgc gagagttgtt tttcctgccc cgataggacc ttctattgca 23341 ataaaagggg ctgtattcat cggaatcctc cttatatctg aaaaacgtgc gtcagttacc 23401 gaccttcata ttgtatcaca acccttgggt gcccccatga aaaaaagacg tttccaaatt 23461 atcgaaacgt ctttttgaca acattaaatt gatcagacag cagcagccag ttttgtggaa 23521 aggaaagacc cagcttccaa tagctgatgc ctcttaaatt cagctcttta atcagattga 23581 attttgcttg aatcgagcgg gcatcctcga accatacctc gtgccttctg ttttctgcat 23641 cagtatagcg gaagaaagga gcttgagcgg tttggtcata ctgaatggaa gcattgttct 23701 gatcagctat gacaatggct tgctgagggc ttactgctct tgctggagtt ccccctgctg 23761 tatatggcag cgtccagtca tatccatata aattctggcc catgacaatt ttgttcgcag 23821 gcatttcagt caaagcatat tctatgacat cacggacagg tccaattgga gaaaccgctt 23881 gaggcggtcc gccgctatag ccccattcat atgtcatgag aacaacaaag tcgacaattt 23941 cgccatgtgc cctgtaatca tgagcttcat accacctgcc ctgctgtgtt gcacttgttt 24001 taggagcaag agccgtagaa atttctaagc cctctcgatg gaaaagatcc cttgcttcgc 24061 ggaggaattg attataggcc tctctatcct ggggccgcaa atattcaaag tcgaaatgaa 24121 tgtcacggaa gccatatctt ctggcattct cgactatttc atttagaagc cgtcttttta 24181 cagtttcgtc gttcaaaagg atccggccaa gttcatcgct gaatgcctgg ttttctaggt 24241 tcgttataat catcatcaat gttgtatttt gactttctgt aatgctcctt aaattcgtta 24301 aaggcggtgc gactaaggtt ccgttccgct gtgcctggaa gctgaatgcg ccaaggtaag 24361 ttaagtaggg cgacgcttct ctggccgcct gctggagatt ttcgctgact tgatttcctc 24421 ggggctccaa ataagcattt gattcgatgt ctcgtttagg agctggaggg atgtataaac 24481 ggaaaccaat ctgaagcacg gtatttaact ggatgcggtt aacccttgcg agctcggctg 24541 ctgttgtatt gaactgccgg gcgatggatg tcagggtatc acctcgcttc acatcataga 24601 actggccagc tattggaatg acaatggttt gtccgacaac aaggctgtcg ggattcggta 24661 tttcattcgt ttcagtgatg tcatttgtgg ttgttctgta ttgtgaagcg atagcagaaa 24721 gagtgtcgcc ttgttttacc acataaattt gaatgaaaaa cgcctccttt catatcgcta 24781 tcaatgtatg aaagaaaagc gctgatcatg tttatttttc tataatttgt tcttccgtcg 24841 taatttctgc gaaaagaaca ttctccatca tggttaaggc gaattcgtta tcttcgtcac 24901 tgtttgacgc gatacagtcc ttaggaatcg tgatgctgta ttccctcata taagcgtcat 24961 tagcggtaaa cagcacgcat atattgccgg ctatacctgt tatgataata tgtctcacct 25021 gcaactcagt aagaagggtg tgaagtgctg tttcgtagaa agcggaatgt ttcggtttga 25081 ttaaaaaata atcagcatct accggagcta tctttgtgat gatatccttg cttctttcat 25141 ttgtgcattc ttgctgtatg tttttaatgt cagcttgcca aagtccataa tgatcattga 25201 tgtaaataat cggccattca ttttgtctcg cgtgctcctt taatgataaa atatgaggaa 25261 cgattttttc tgttttttta gcgagggttt cccccatatc gaattcaaaa ttattgatca 25321 tgtctacaat gagaagggct ttatctgctt tggacaatcg acagtctcct ttccgtttca 25381 gttatagtta atatgtagcc tttttaggca atgaaaaaac tttgaaaaga gagcttatcc 25441 ttatgacaca agatgaactt tatatgaaag aagcaattaa agaagcgaaa aaggctgaag 25501 agaaaggtga agtgccaata ggtgcggtgc ttgtcattaa tggtgaaatt atagcgcgtg 25561 cgcataattt aagagagact gaacagcgat ctattgccca tgcagaaatg cttgtaattg 25621 atgaagcgtg taaggcactc ggaacatggc ggctggaagg tgcgactctt tatgtgacgc 25681 ttgagccttg tccaatgtgt gctggtgcag tcgtactttc tcgagtggaa aaagtggttt 25741 ttggcgcatt tgatccgaaa ggcggctgtt caggcacgct aatgaacctt cttcaggagg 25801 aacgctttaa tcatcaggct gaagtggtga gcggtgtgct tgaggaagaa tgcggcggaa 25861 tgctcagtgc gtttttcaga gaactaagaa aaaagaagaa agccgccagg aaaaacttgt 25921 ctgaatagta cggttgcaat ttttagggga aacagatata cttaagtgtg catcgtaata 25981 gatgcaacat aaaatttgat atttattttg ccgtgctaag cggggaggta gcggtgccct 26041 gtacctgcaa tccgctctag cagggccgaa tcccttctcg aggttcgttt actttaaggc 26101 ctgccttaag taagtggtgt tgacgtttgg gtcctgcgca atgggaattc atgaaccatg 26161 tcaggtccgg aaggaagcag cattaagtga aacctctcat gtgccgcagg gttgcctggg 26221 ccgagctaac tgcttaagta acgcttaggg tagcgaatcg acagaaggtg cacggtaaat 26281 caatcatcaa attttcagac tcacctaata ttaggtgagt tttttgttat gtaaaaagag 26341 cttttggaat cgaaacaagg ttcatgtata atgggaatga tgaataacgg aggagggcaa 26401 acccgtgagt taccaagctt tatatcgagt attcaggcct cagcgctttg aagatgtggt 26461 cggacaagaa cacattacaa aaacgctgca aaatgccctt ttgcaaaaaa agttttctca 26521 cgcctatctg ttttccgggc ctagaggaac cggaaaaacc agtgcagcca aaatatttgc 26581 taaggctgtc aactgtgaac atgctcctgt tgatgagcca tgcaacgaat gtgcggcctg 26641 taaagggata acaaacgggt caatatccga tgtcatagaa attgacgccg cttctaataa 26701 cggtgttgat gagattcgtg acattcgcga taaagtgaag tttgccccat cggccgtcac 26761 atataaggta tatatcatag atgaggtgca tatgctttct atcggcgctt ttaatgcatt 26821 actaaaaaca ttagaagagc cgcctgagca ttgtattttc atattagcaa caactgaacc 26881 gcacaaaatt cctttaacca ttatctctag atgtcagcgt tttgacttta aacgaattac 26941 ctcccaagcg attgtaggcc gcatgaataa aattgttgat gctgaacagc tgcaagtgga 27001 ggaaggatcg ctggaaatca tcgcgagtgc tgcagacgga gggatgaggg atgccctgag 27061 ccttcttgat caggccatat cattcagcgg cgatatcctg aaagtcgaag atgcgctttt 27121 aattacgggt gctgtttctc aattatatat cgggaagctt gcaaaatccc tgcatgataa 27181 aaacgtttct gacgcactgg aaacattaaa tgaattgctt cagcaaggaa aagatccagc 27241 taagctgata gaagatatga ttttctattt cagggacatg ctgctgtaca aaacagcccc 27301 tggcttagag ggagtgcttg agaaagtaaa agtcgatgaa acgttccggg aactaagtga 27361 acaaattccg gctcaggccc tatatgaaat gattgatatt ctgaacaaga gccatcagga 27421 aatgaaatgg acaaatcatc cgcgtatctt tttcgaagtg gccgttgtga agatttgcca 27481 aacctcacat caatctgctg ctgatctccc ggaagtggat atgctgatga aaaaaatcca 27541 gcagctcgaa caggaagtag agcggctcaa aacaacgggc ataaaagcag ctgcggaaag 27601 cccgaaaaaa gaagcgccgc gtgtgccaaa gggcgggaaa tccaattaca aagcgccagt 27661 aggcagaatt catgagattt tgaaggaagc cacaagaccg gatcttgatc tgctcagaaa 27721 cagttggggc aagcttcttg ctcatctcaa acagcaaaac aaagtatcac atgccgcttt 27781 gctgaatgac agtgaacctg tggctgccgg atcggcggca tttgttctga aattcaaata 27841 tgaaattcat tgtaaaatgg tcgctgagga taacaacgga gtccggacta atcttgagca 27901 gattttagaa tcgatgctcg gaaaaagaat ggatttgatt ggcgttccag aagcacaatg 27961 gggtaaaata agagaagaat ttttagaaga tcatcagcag gaaaatgaag gatcaaatga 28021 accggctgaa gaagacccgc ttattgccga agcgaaaaag cttgttggag cggatttaat 28081 tgaaataaaa gactaacaaa atgaaagaga gtgaatgcta tgcgtggcgg aatgggtaat 28141 atgcaaaaaa tgatgaaaca aatgcaaaaa atgcaaaagg acatggcgaa ggctcaagaa 28201 gagcttgcag aaaaggttgt tgaaggaact gcaggcggcg gtatggtaac agtaaaagca 28261 aacggccaaa aagaaatcct ggatgttatc atcaaagaag aagtcgttga tcctgaagat 28321 attgatatgc ttcaagattt agtgcttgct gcaacgaatg aagctttgaa aaaagttgac 28381 gaaatcacaa acgaaacaat gggtcaattt acaaagggaa tgaacatgcc aggtttattc 28441 tagggggata aaagaacatg caatatcctg aaccaatatc aaagctgatt gacagcttta 28501 tgaaattgcc agggatcgga ccgaaaacag cggttcgtct ggcttttttt gttctaggta 28561 tgaaagaaga tgtagtatta gattttgcga aagcattagt aaatgcgaaa cgcaacctga 28621 catattgttc agtttgcggg catattacag atcaggaccc ttgctatata tgtgaagata 28681 cgcgcaggga taagtctgtt atctgtgttg tgcaagaccc taaagacgtt atcgctatgg 28741 agaaaatgaa ggaatacaac ggacagtatc acgttcttca cggcgctatt tctccaatgg 28801 acggcatcgg accggaggat attaaaatac cagaattgtt aaaacgatta caggatgatc 28861 aagtgacaga agtgatcctc gcgacaaacc ctaatataga aggggaagca acagcgatgt 28921 atatatcaag gctcctcaag ccgtctggta ttaagctctc ccgtattgcc cacggactgc 28981 ccgtcggcgg tgatttggaa tatgctgatg aggtcactct ttctaaagca cttgaaggaa 29041 gacgtgaatt gtaaggagga aaaagcgatc catgggtttt cttcgcaaga aaacattaag 29101 aagagagttt gatgaaaaac taaccgagca gctttttaag caaaaggaag agtggaacag 29161 gcaaaaaaag ctggttgaaa aaagcttaga accgtctgct gaagtgttat acgaactgaa 29221 agtagctgaa gcgaagtatt ttttttactt aagggaagcg aagcagcgaa atttaaaaat 29281 cagccggtgg aagtaagtgg tctaaactcc tggatcttct cataagcttg tactagaaca 29341 agcgaaggag atgagaagat tcatggagcc tatttttatt attgggatta ttttaggact 29401 ggttattctt ctttttttat caggttcagc agcgaagcct ttaaagtgga ttggcatcac 29461 agctgttaaa tttgtggcag gtgctttgct gctggtttgt gtaaatatgt ttggcggcag 29521 tcttggcatt catgtgccga ttaatctggt tacaacagct atcagcggaa ttttaggaat 29581 acccggaata gctgcgttag tcgtcattaa gcaatttatc atttaattga tattatgtat 29641 tgacttagac aactgaaggt gttattctaa tatacgtcgc tgatgacgaa cagctttttt 29701 gaaaagaaaa tgctaaaaag ttgttgacag tagcggcggt aaatgttatg ataataaagt 29761 cgcttaaacg agcggtaaac aaagttcttt gaaaactaaa caagacaaaa cgtacctgtt 29821 aattcatttt tataaatcgc acagcaatgt gcgtagtcag tcaaactact ttatcggaga 29881 gtttgatcct ggctcaggac gaacgctggc ggcgtgccta atacatgcaa gtcgagcgga 29941 cagatgggag cttgctccct gatgttagcg gcggacgggt gagtaacacg tgggtaacct 30001 gcctgtaaga ctgggataac tccgggaaac cggggctaat accggatggt tgtttgaacc 30061 gcatggttca aacataaaag gtggcttcgg ctaccactta cagatggacc cgcggcgcat 30121 tagctagttg gtgaggtaac ggctcaccaa ggcgacgatg cgtagccgac ctgagagggt 30181 gatcggccac actgggactg agacacggcc cagactccta cgggaggcag cagtagggaa 30241 tcttccgcaa tggacgaaag tctgacggag caacgccgcg tgagtgatga aggttttcgg 30301 atcgtaaagc tctgttgtta gggaagaaca agtaccgttc gaatagggcg gtaccttgac 30361 ggtacctaac cagaaagcca cggctaacta cgtgccagca gccgcggtaa tacgtaggtg 30421 gcaagcgttg tccggaatta ttgggcgtaa agggctcgca ggcggtttct taagtctgat 30481 gtgaaagccc ccggctcaac cggggagggt cattggaaac tggggaactt gagtgcagaa 30541 gaggagagtg gaattccacg tgtagcggtg aaatgcgtag agatgtggag gaacaccagt 30601 ggcgaaggcg actctctggt ctgtaactga cgctgaggag cgaaagcgtg gggagcgaac 30661 aggattagat accctggtag tccacgccgt aaacgatgag tgctaagtgt tagggggttt 30721 ccgcccctta gtgctgcagc taacgcatta agcactccgc ctggggagta cggtcgcaag 30781 actgaaactc aaaggaattg acgggggccc gcacaagcgg tggagcatgt ggtttaattc 30841 gaagcaacgc gaagaacctt accaggtctt gacatcctct gacaatccta gagataggac 30901 gtccccttcg ggggcagagt gacaggtggt gcatggttgt cgtcagctcg tgtcgtgaga 30961 tgttgggtta agtcccgcaa cgagcgcaac ccttgatctt agttgccagc attcagttgg 31021 gcactctaag gtgactgccg gtgacaaacc ggaggaaggt ggggatgacg tcaaatcatc 31081 atgcccctta tgacctgggc tacacacgtg ctacaatgga cagaacaaag ggcagcgaaa 31141 ccgcgaggtt aagccaatcc cacaaatctg ttctcagttc ggatcgcagt ctgcaactcg 31201 actgcgtgaa gctggaatcg ctagtaatcg cggatcagca tgccgcggtg aatacgttcc 31261 cgggccttgt acacaccgcc cgtcacacca cgagagtttg taacacccga agtcggtgag 31321 gtaacctttt aggagccagc cgccgaaggt gggacagatg attggggtga agtcgtaaca 31381 aggtagccgt atcggaaggt gcggctggat cacctccttt ctaaggatat tttacggaat 31441 ataagacctt gggtcttata aacagaacgt tccctgtctt gtttagtttt gaaggaactt 31501 tgttccttga ataagttaag atgggcctgt agctcagctg gttagagcgc acgcctgata 31561 agcgtgaggt cggtggttcg agtccactca ggcccaccat cttatataac ggggccttag 31621 ctcagctggg agagcgcctg ctttgcacgc aggaggtcag cggttcgatc ccgctaggct 31681 ccaccaacgt gttctttgaa aactagataa cagtagacat cacattcaat tagtaacaca 31741 agatatcaca tagtgattct ttttaacggt taagttagaa agggcgcacg gtggatgcct 31801 tggcactagg agccgatgaa ggacgggacg aacaccgata tgcttcgggg agctgtaagc 31861 aagctttgat ccggagattt ccgaatgggg aaacccacca ctcgtaatgg agtggtatcc 31921 atatctgaat tcataggata tgagaaggca gacccgggga actgaaacat ctaagtaccc 31981 ggaggaagag aaagcaaatg cgattccctg agtagcggcg agcgaaacgg gattagccca 32041 aaccaagagg cttgcctctt ggggttgtag gacactctgt acggagttac aaaggaacga 32101 ggtagatgaa gaggtctgga aaggcccgcc ataggaggta acagccctgt agtcaaaact 32161 tcgttctctc ctgagtggat cctgagtacg gcggaacacg tgaaattccg tcggaatccg 32221 ggaggaccat ctcccaaggc taaatactcc ctagtgaccg atagtgaacc agtaccgtga 32281 gggaaaggtg aaaagcaccc cggaagggga gtgaaagaga tcctgaaacc gtgtgcctac 32341 aagtagtcag agcccgttaa cgggtgatgg cgtgcctttt gtagaatgaa ccggcgagtt 32401 acgatcccgt gcaaggttaa gcagaagatg cggagccgca gcgaaagcga gtctgaatag 32461 ggcgcatgag tacgtggtcg tagacccgaa accaggtgat ctacccatgt ccagggtgaa 32521 gttcaggtaa cactgaatgg aggcccgaac ccacgcacgt tgaaaagtgc ggggatgagg 32581 tgtgggtagg ggtgaaatgc caatcgaacc tggagatagc tggttctctc cgaaatagct 32641 ttagggctag cctcaaggta agagtcttgg aggtagagca ctgattggac taggggcccc 32701 taccgggtta ccgaattcag tcaaactccg aatgccaatg acttatcctt gggagtcaga 32761 ctgcgagtga taagatccgt agtcgaaagg gaaacagccc agaccgccag ctaaggtccc 32821 aaagtatacg ttaagtggaa aaggatgtgg agttgcttag acaaccagga tgttggctta 32881 gaagcagcca ccatttaaag agtgcgtaat agctcactgg tcgagtgact ctgcgccgaa 32941 aatgtaccgg ggctaaacgt atcaccgaag ctgcggactg ttcttcgaac agtggtagga 33001 gagcgttcta agggctgtga agccagaccg gaaggactgg tggagcgctt agaagtgaga 33061 atgccggtat gagtagcgaa agaggggtga gaatcccctc caccgaatgc ctaaggtttc 33121 ctgaggaagg ctcgtccgct cagggttagt cgggacctaa gccgaggccg aaaggcgtag 33181 gcgatggaca acaggttgat attcctgtac cacctcctca ccatttgagc aatgggggga 33241 cgcaggagga tagggtaagc gcggtattgg atatccgcgt ccaagcagtt aggctgggaa 33301 ataggcaaat ccgtttccca taaggctgag ctgtgatggc gagcgaaata tagtagcgaa 33361 gttcctgatt ccacactgcc aagaaaagcc tctagcgagg tgagaggtgc ccgtaccgca 33421 aaccgacaca ggtaggcgag gagagaatcc taaggtgatc gagagaactc tcgttaagga 33481 actcggcaaa atgaccccgt aacttcggga gaaggggtgc tctgttaggg tgcaagcccg 33541 agagagccgc agtgaatagg cccaggcgac tgtttagcaa aaacacaggt ctctgcgaag 33601 ccgtaaggcg aagtataggg gctgacgcct gcccggtgct ggaaggttaa gaggagcgct 33661 tagcgtaagc gaaggtgcga attgaagccc cagtaaacgg cggccgtaac tataacggtc 33721 ctaaggtagc gaaattcctt gtcgggtaag ttccgacccg cacgaaaggc gcaacgatct 33781 gggcactgtc tcaacgagag actcggtgaa attatagtac ctgtgaagat gcaggttacc 33841 cgcgacagga cggaaagacc ccgtggagct ttactgcagc ctgatattga atgttggtac 33901 agcttgtaca ggataggtag gagccttgga aaccggagcg ccagcttcgg tggaggcatc 33961 ggtgggatac taccctggct gtattgacct tctaacccgc cgcccttatc gggcggggag 34021 acagtgtcag gtgggcagtt tgactggggc ggtcgcctcc taaaaggtaa cggaggcgcc 34081 caaaggttcc ctcagaatgg ttggaaatca ttcgcagagt gtaaaggcac aagggagctt 34141 gactgcgaga cctacaagtc gagcagggac gaaagtcggg cttagtgatc cggtggttcc 34201 gcatggaagg gccatcgctc aacggataaa agctaccccg gggataacag gcttatctcc 34261 cccaagagtc cacatcgacg gggaggtttg gcacctcgat gtcggctcat cgcatcctgg 34321 ggctgtagtc agtcccaagg gttgggctgt tcgcccatta aagcggtacg cgagctgggt 34381 tcagaacgtc gtgagacagt tcggtcccta tccgtcgcgg gcgcaggaaa tttgagagga 34441 gctgtcctta gtacgagagg accgggatgg acgcaccgct ggtgtaccag ttgttctgcc 34501 aagggcatcg ctgggtagct atgtgcggac gggataagtg ctgaaagcat ctaagcatga 34561 agcccccctc aagatgagat ttcccattcc gcaaggaagt aagatccctg aaagatgatc 34621 aggttgatag gtctgaggtg gaagtgtggc gacacatgga gctgacagat actaatcgat 34681 cgaggactta accacatttt gaatgatgtc acacctgtta tctagttttg agagaacacc 34741 tctctaaagg cggaaggtaa ggaaactccg ctaagggctc tcacatcctg tgagaaacgc 34801 ccagtacctt catcctgaag gcatttgttt ggtggcgata gcgaagaggt cacacccgtt 34861 cccataccga acacggaagt taagctcttc agcgccgatg gtagtcgggg gtttccccct 34921 gtgagagtag gacgccgcca agcaagctta aacccagctt aatgagctgg gttttttgtt 34981 tactcaagat cgagaaaatc aaacaaatac aaacaccgag ggcttatata gcccatatac 35041 tgatttaaag tttcaaaaag gtctaaatag tgtatacaat atccgtttta aggggaggct 35101 aactgtacgg aggtggagaa gatggacgaa acagttaaac ttaatcatac atgtgtgatt 35161 tgtgatcaag agaagaatag aggcattcat ctttatacga aattcatatg cttagattgt 35221 gagagaaaag taatttctac atcaacttct gatcctgact atgcgtttta cgtaaaaaaa 35281 ctaaagagca ttcatacacc gccattatat tcatagacct gaaaaggtct ttttttgtac 35341 tcttaataat aaaaagaaga tgaaacttgt ttaaggattg aacgtagtag ataataatat 35401 taaaactgag tatagacaca ggagtcgatt atctcatgca gagatttttt cactttttgg 35461 tgtggagttt aactagcagt gcgacttttg ttttcattgg aatattgagc ttttttggtt 35521 taaaccagtc gattttttta tctattgttt atgggcttgc ttctggagca gccgtatata 35581 tagctggcat ctggaatgca agacggttat ttcttaaaaa gcatgaattg acaggaagag 35641 agtatgctta cattaagaaa aacttagagg aagcaaggca gaaaatggtc cgtcttagga 35701 aagccttgtt tcaggctaaa agcattcaaa tgtttaagca aaatgcagaa atgctaagga 35761 ttgtgagaag gatttatctc ctcaccaaaa aagagccaaa gcggttttat caggcagaac 35821 gattttttta tcaaactctc gattcggttg ttgaattgac agagaagtat gcttttctat 35881 catctcaccc aaaaaaaagc aaagaactgt cgatgtcgtt aagtgagaca cgcatcactc 35941 ttactgaatt gaccaagcgt ttagaggaag atttaactca agcaatgggt gatgaaattg 36001 acgagttgca gtttgaatta gacgcagcaa aacattcatt aaagaaataa gggaagaggg 36061 taagagcgat gaaccgagac caaagcgacc ttcatataga tgaattattg gcagatcctt 36121 ttggtggtaa catagagata ccaggttcgg aggctgtaaa agcagagaaa gagcaagtac 36181 ggcttgttga tgttcttcct gaggaaaaca aggaaaaagc aattcagctt gctggacaga 36241 ttgatcataa aaatatgcaa agcattgtct tatacggttc acaagctcaa tctaaactgc 36301 tgaacttttc tcatgatatg attaatcatg ttcaaaagaa ggatgtcggg gagattggcg 36361 aaatacttgg agagctgatg aaaaagctgg agcaagtaaa tcctgatgat ctccaatcta 36421 agaaaaaggg ttttttggca cgcatgtttg gaagagtatc aagttctctt caagaggtgc 36481 tgtctaaata ccaaaagacc agtgtgcaga tagacagaat cagcttgaag ctggagcact 36541 ctaaaaatgc tttaatcagt gacaacaagc tgttagagca gttatatgaa aaaaataaag 36601 aatatttcgc agcgctgaat gtttatattg ctgcaggaga actgaagctg gaggaattaa 36661 aaacaaaaac gattcctgaa ctgaagcaac aggctgaatc gagtgatcat aaccaaatgg 36721 ccgttcaaga ggtgaatgat ttaattcaat ttgctgaccg gttagataaa agggtgcatg 36781 atttgctgct gagcaggcaa attacaatcc aaagtgcacc gcaaatcagg ctgattcaaa 36841 atacaaacca agcgttagct gaaaagattc agtcatccat tgtgacagcg attccgttat 36901 ggaaaaatca agttgccatt gcactgacgc ttttaaggca gcgcaatgca gtggatgcac 36961 agcagaaagt atctgataca accaatgagc ttttgctgaa aaatgcggag cttttaaaaa 37021 ccaatacaat tgaaactgca cgggcaaatg aaagaggcct tgttgatata gataccttga 37081 agaaggtgca ggaaagctta ataagcacgc ttgaagaaac actgactata caagaagaag 37141 gacgaatcaa acgccgtcag gcagaagaag agctcatgat gatggaaggc gacctgaagc 37201 aaaagctgat tacaataaag gaaagatgat taccagtaag tctggcttta agttctgtca 37261 gaggcacgat ataataaggt gtaagaagac acattcaaag gattgttttc atgaacacac 37321 ctttatataa agcattaatt caacatgcga gaagaaattc tcattcattt catgttccgg 37381 gacatcacaa tggagatgtc ttttttgatg acgctaagtc aatattcgat ccgcttctca 37441 ccattgatgt aactgaactg gcaggactgg atgatctcca tcatccttct ggggtgatta 37501 aggaagctca ggagcttgcc agtcaattat atggatcggc ggaaagtttt tttctggtaa 37561 atggtacgac tgtcggaaac ttagcgatga ttttatctgt ttgtgaacct ggtgatacaa 37621 ttctggttca aagaaactgt cataaatctg tatttcatgc tgttgatttg tccggtgctg 37681 agccggttta tcttgcacct gacgttgatt cagcgatgca tgtgcctacg catgttccgc 37741 ttggaacaat taaagaggcc ctggaagcat atccagatgc gaaaggcttg gtactgacca 37801 atccgacata ttacggacat agtgctgatt tgactgagat cattactgaa gcccatcatt 37861 acgggattcc tgttttggtc gatgaagcgc atggcgcaca ttttatttta ggtgagcctt 37921 ttccggtctc agctttaaaa atgggggcag atattgttgt tcagtcggcc cacaaaacgt 37981 tgccagccat gacgatgggt tcttatttgc atctcaacag cagctgcagg attaacaggg 38041 atcgggtggc agagtattta aaccgattac aaagcagcag cccgtcttat ccgattatgg 38101 cttcgttaga tattgcccgc gcttatgtac agcatattat agaagaacaa aagctttctg 38161 acattctgca gcggatagaa acacttaaac aaacgtttga ttcacttaca aatgcagaag 38221 ctgttaaccc tgctaatcca ctgatcatca cggatccgct aaagctcaca attcgttcaa 38281 aacgcgggca ttctggctat acgctgcaaa gcattttaga gcgtgccaac atattcactg 38341 agcttgctga tgaaaatcaa gttctgctcg ttctcccatt gggaggaaaa cggagaataa 38401 acgctgaaat cattagaagc atcgatgaag agattgagaa aacgcctccg gatcagacgt 38461 ttgtttctgc agaatggggt gtgcagcctg ttactgtctt gccttatcca aaaaaggtct 38521 tacattcgtt taagaaagaa tatgtgagct ttgaggaagc agctggccgg cttaatgcag 38581 aagatatcat cccttatcct ccgggtatcc cgatgattat ggcgggagaa agaataacaa 38641 aagaaagtgt gcaaaagctc agccgcttga tcagcatgaa aacgcatgtt caagggaata 38701 tgaaaatcaa agagaaacaa ctacttgttt atatagaaga ggagaaatca tgagcggttt 38761 atttattaca ttcgaaggtc ctgaaggtgc agggaaaacg actgttctgc aggagatcaa 38821 aaacatactg acagcagaag gccttcaggt tatggcaact cgagagccag gcggaataga 38881 tattgcagaa caaattagag aggttattct gaatgagaac aatatattaa tggacccaaa 38941 aacagaagct ctcttatatg cggctgcaag acgccagcat ttagttgaaa aagtaaaacc 39001 tgctttagaa caggggttta tcgttctttg cgacagattc atagacagtt ctcttgcgta 39061 tcaaggatat gcaagagggc ttggaattga tgaggttctg tccattaatg aatttgccat 39121 tggagatatg atgccccatg taacggttta tttttcaatt gatccggaag aaggactgaa 39181 gcgtatttac gcaaacggct cacgggagaa aaacaggctc gatttagaaa aactggactt 39241 tcatacaaaa gtacaagaag gttatcaaga gctgatgaag cgatttccgg aaagatttca 39301 ttcagttgat gccgggcaat ccaaagacct cgtcgttcag gatgttctaa aggtgatcga 39361 tgaagcgttg aaaaaaattc aattgtgacc tgtttcccaa tagttgatat aataatgtaa 39421 acgagatcac gttgtttcca atctaaagga ggccttcaca gatgaaattg atagtggcag 39481 ttgtacaaga tcaggacagc aacagacttt tgaaaacctt aacggatcac aacttcagag 39541 tcacaaagct tgcaacgaca ggaggatttc ttaaatcagg caatacaacg tttatgatcg 39601 gtgtcgagga tatacgcgtc aataaagcgt tgagtctcat taaagaaaac gggcagaaac 39661 gtgatcagat gattgcccct gtatctccaa tgggtggaaa tgctgattcc tatgtccctt 39721 atccagtcga agttgaagtt ggcggagcga cagtatttgt ccttccagtc gatgaatttc 39781 atcaatttta aggatctgaa actgtgaaaa ttaataaaga tatacgtaca tttatagata 39841 ataagcagat tccctctgtg aaaacatctg agatcacagc atcgtttaaa acatcaatgg 39901 aaaaccaaag cagcaaaatg aagcttgatc agcttaccag gctgttatct gatatagaag 39961 catttggaaa aaggctaacg aaatctcgga attttaaaga cttagcgaga tttaaaggac 40021 ttgtgaaacg ttttgtcaaa gaagctgtgg acagcggtct ttcacatgaa acatcgaaaa 40081 gctttgacct ttacgggaac agcagaacgc tgggacttgt gaaagaaata gatgacaaat 40141 tgatacagct tacggaagag atgatggatc aggaaaaacc ggcaattgat ttgctggagc 40201 gtattggcga aataaaaggt ttattaatta acctttacac atagagagtg atacaatggc 40261 aatatcctgg aaggaaatga acgagcttca gcccagagtg atgaagcttt tatataatag 40321 tattgagaag gacagactat cacacgctta tttgtttgag gggaaaaaag gaacaggcaa 40381 gcttgatgcc gcgctgcttc ttgcaaaaag cttcttttgt ctggagggtg gcgcggagcc 40441 ttgtgagagc tgccgaaact gtaaacggat agagtcaggg aaccatcctg atctccatct 40501 tgttcagcct gatggcttat caatcaaaaa ggcgcaaatt caagcgctcc aagaagagtt 40561 ttctaagaca ggacttgaat cgcataaaaa gctgtatatt atttcgcacg cagatcaaat 40621 gacagcaaat gcggcgaaca gcctgctgaa atttttagaa gaaccgaaca aagacacaat 40681 ggccgtcctc atcactgagc agccccaaag gttattggat accatcattt caagatgcca 40741 aacccttcct tttcagcctt tgcagccgaa agcaattgaa gacagactga tcgaacagga 40801 cgtctcgcct catatggcaa ggcttctggc caacatgact aataatgtag cagaagcagt 40861 cgaattaagt cgaaatgatg agtttgcaga gtctagagcg aaagtgataa aattgtatga 40921 agtcctacac cagcggaaag gacatgcttt tttctttatt caagatcaat ggatgccctt 40981 tttcaaagaa aaaacccatc aagaaatggg tcttgatatg ctcttattga tatatcgtga 41041 tgtgttgtcc atccaaatag gaaatgaaga taaattgatt tatcaagact tattccaatc 41101 aataaaacag catgcgctac aatcaacaca acaaagcgtt acgaatcaga tacttgctgt 41161 tttagaagca aagaaacggc ttcattccaa tgtgaatgta caaggattaa tggagcactt 41221 ggtgttaatg ttgcaggagg gataagcttg tacaatgtaa ttggtgtccg ctttaagaaa 41281 gcgggtaaaa tatattattt tgatccgaat ggatttcata tagaacatga cagctgcgta 41341 attgtagaaa ctgtcagagg cgttgagtac ggccaggtcg taattgcaaa taaacaggtg 41401 gatgagcatg atgtggtgct tccccttcga aaagtgatac gtgtggcaga cgatcgcgat 41461 cttctcattg tagaagaaaa taaacaggaa gcactatcag catttgatat ctgccaaaag 41521 aaagtgattg agcatggctt ggatatgaag ctggtcgatg ttgaattcac gtttgatcgc 41581 aataaagtca ttttttactt cactgctgac ggccgagtcg actttagaga gcttgtaaag 41641 gatttggctt ctatctttaa gacaagaatt gagctgcgcc aaatcggagt gagggatgag 41701 gcaaaaatgc tcggaggaat cggtccttgc ggaagaatgc tttgctgttc aacgtttctt 41761 ggagattttg aacccgtttc cattaaaatg gccaaggatc agaacttgtc tttaaatcct 41821 acgaagattt cgggtctttg cggacgattg atgtgctgtc taaaatatga gaacgatgag 41881 tatgagacgg caaaagaaca gcttccggat ataggagaaa tgattacgac agcaaacggt 41941 cccgcgaagg tcgtcggact aaatattctg gaacgggtgc ttcaggtgga actgataaac 42001 cgtgaaaaag tgatagaata tacttgggaa gagctcttgg aagagggcgt cgtatccgca 42061 caaaccacag attaacgagg tgtggaacct tggataaaaa agagttattt gatacagtca 42121 ttaacttaga agaacaaatt ggctcactgt accggcagct gggggatttg aagcagcata 42181 tcggtgagat gattgaggaa aatcatcatt tacagcttga aaacaagcat ttgcgcaaac 42241 ggctggacga tacgacgcag cagattgaaa agttcaaagc tgataaaaaa gaatcaaaaa 42301 cacagaagac agagcaaact gatatagggg aaggatatga taatctggca cgtctgtatc 42361 aagaaggatt tcatatctgc aatgtccact atggaagtgt tcgaaaagag gattgtcttt 42421 tctgtctgtc attcttaaat aaaaaatagg gaaaaggctt ccgcataaga cgggagcctt 42481 tttcaaaggt actgaaagga taagaagatg gtttcattac atgatgatga aagattagat 42541 tatttgctgg cagaggacat gaaaatcata caaagcccaa cagtgtttgc tttttcgttg 42601 gacgctgtgc ttctgtccaa atttgcgtac gttccgattc aaaaagggaa aattgttgat 42661 ttatgcaccg gcaatggtat tgtgccgctg ctgctcagta caagatcaaa agcagacatt 42721 ctgggagtcg aaattcaaga aagactgcat gatatggctg ttcgcagcgt ggagtataat 42781 aagttggacg atcagatcca gatcatacat gatgacctga aaaacatgcc ggagaaactt 42841 ggacataatc gatatgatgt tgtcacctgc aatccgccgt attttaaaac gccgaaacaa 42901 actgaacaaa acatgaacga gcatctccga atcgcaagac atgaaatcca ctgcacgctg 42961 gaggatgtca tttcagtcag cagcaagctg ctcaagcaag ggggaaaagc agctcttgtt 43021 caccggccgg gaaggcttct ggagattttt gaactgatga aggcttatca aatcgagccg 43081 aaacgtgtac aatttgtcta tccgaagcaa gggaaagaag ccaataccat tttggttgaa 43141 ggtatcaaag gcgggcgccc ggatttgaaa attcttcctc ccttattcgt atatgatgaa 43201 caaaatgaat atacaaaaga aatcaggacc attttatatg gagacaaata accatttctt 43261 ctacgtcgtg aaatgtaagg acaatagctg gtatgccggg tataccaacg atctgcataa 43321 acgagtgaaa acgcacaatg atggaaaggg cgcaaagtac acaaaagtaa gacgtccggt 43381 tgaattaatt tttgccgaga gcttttcaac aaagcgggaa gctatgcagg cggaatatta 43441 tttcaaaaaa ctaactcgga agaaaaaaga gctttatata gaagaaaagc ggaacagcaa 43501 ggaggctgta tatgttaagg cgccaaatga gctttaatgg aaagtcggac atggggattc 43561 tttacttggt cccaacccca atcggaaatt tagaggatat gacattccgg gcgatcgaca 43621 cgctgaaatc agtggatgcg attgctgcgg aagatacgag gcaaacgaaa aagctttgtc 43681 atgtatatga aattgaaaca ccgctcgtca gctatcacga acacaataaa gaaagcagtg 43741 ggcacaaaat tattgaatgg ctgaaatcgg gaaaaaacat tgctcttgtc agtgatgccg 43801 gtctgccgac gatttctgat cccggagcgg aaattgtaaa ggattttacg gatataggcg 43861 gttatgttgt tccgttgccg ggagcaaatg ctgcattaac agctcttatt gcttcaggta 43921 ttgtaccgca gccttttttc ttttacggtt ttctcaacag acagaaaaaa gaaaagaaga 43981 aggagcttga agcccttaaa aaacggcagg aaacgatcat tttttatgaa gcgccccaca 44041 gattgaagga aaccttgtca gcgatggcag agatattagg agatcgggaa attgctgtaa 44101 cacgtgaact cactaagaaa tatgaagagt ttatccgagg aaccatatct gaggtcattg 44161 gatgggcaaa cgaggatcag atacgcggcg agttttgtct tgtcgtagaa ggaagtaata 44221 atgaagaggt agatgaggaa gaacaatggt gggaaaccct cactgcgaaa gaacatgtcg 44281 agcattacat ttcgaaaggc gctacgtcta aagaagctat taaaaaagca gcagtcgatc 44341 gcaatgtacc aaagcgtgaa gtgtacgatg cttaccatat taagcaataa aaaaacgttc 44401 ttgtgtcata acaagaacgt tttttgtaca agaaatgatt atttaaggtt ttgaagctgg 44461 ttttggattt cgctgatgat ttgctcagcg ccttctttac taagaaccaa tttaccgcct 44521 gcaagtttaa ggttatcatc agaaacttca ccagttactt ggcaagtcat gtttggttta 44581 tattttttaa ggatgatttt ttcatcatca acatagattt caagagcatc tttttctgcg 44641 attccaagag tacgacgcag ttcgatagga ataactacac gtcctaattc atcaacttta 44701 cgtacaatac cagtagattt cataaacatt ctcctcccaa gagatactta tttgtttaaa 44761 ttatattttt cttcgtcatt attcgacaaa atccttacct tcatagcata acaaggtttc 44821 caataatcgt caatcatttt gtttactatt gattgtaaga attagttctt atagtcagta 44881 atgtcttgga aactaccgaa ataacagcat tttataaata tttaataaag ctattatcct 44941 actaaaaatc cttttaaatc aagactttcg aaccaaagtt ttttatttca tttgattata 45001 tacgacaaaa ttcgacacga acagactttt tttattttca ttaaagattt ttaattttaa 45061 ttattctttt tcagggcgta tgtatatatt cttgatctta aaggctaaga tggtatcata 45121 gataaaggat aaatataaat aatattcata tatgatttgc acttatcgcc gctctcgtcc 45181 tttgggcggg agctttttga cattctgatt aggaggtttc aagatgccgc aagaaaacaa 45241 tacattttac attacaacac cgatttatta tccgagcgga aaattacata tcggccatgc 45301 atatacgaca gtcgcaggag atgcaatggc acgttacaaa agattaaaag ggttcgatgt 45361 tcgctattta acgggaacgg acgagcatgg acaaaagatc cagcaaaaag ctgaacagga 45421 aaacattaca cctcaggagt atgtggatcg cgcagcggca gatattcaaa aactgtggaa 45481 gcagcttgaa atctcaaacg acgactttat ccgcacgaca gaaaaacggc ataaagttgt 45541 cattgaaaaa gtgtttcaaa agcttcttga taacggggac atctatcttg atgagtatga 45601 aggctggtac agcatccctg atgaaacgtt ctacacggaa actcagctcg ttgatattga 45661 gcggaatgaa aagggagagg tcatcggcgg aaaaagccct gacagcggtc acccagttga 45721 attgatcaaa gaggaatctt atttcttccg catggggaaa tacgcggatc gtcttctgaa 45781 atactatgaa gaaaacccga cattcattca gccagaatca cgcaaaaacg aaatgattaa 45841 taactttatc aaacctggac ttgaggattt ggcagtatca cgtaccactt ttgattgggg 45901 cgtgaaggtg ccggaaaatc caaagcatgt tgtatatgtt tggattgacg cactatttaa 45961 ctatttaacg gcactcggtt atgatacaga aaatgatgag ctttatcaaa aatattggcc 46021 tgccgatgtt catttagtcg gtaaggagat tgtacgattc catactattt actggccaat 46081 tatgctgatg gcgctggatc ttccgctgcc aaagcaagta ttcgcgcatg gctggctttt 46141 gatgaaagac ggaaaaatgt cgaaatcaaa aggaaacgtt gtagatccgg ttacattaat 46201 tgaacgctat ggtttagacg aacttcgcta ttacttgctt cgcgaagtgc cgttcggatc 46261 agacggtgtt ttcacgccgg aaggatttgt tgagcgaatc aactatgatt tagcgaatga 46321 tttaggaaat ctattgaatc gtactgttgc gatgattaat aagtattttg acggacaaat 46381 cggttcttac aaaggtgctg ttacggaatt tgaccatacg ctcacttctg ttgctgaaga 46441 aacagtgaaa gcttatgaga aagcaatgga aaatatggag ttctcggtag cactttcgac 46501 tttatggcag ctcatcagcc gcacaaacaa atacattgat gagacagctc catgggtgct 46561 tgcgaaagat ccggcaaaag aagaagaatt gcgatcagtt atgtatcatc tcgctgaatc 46621 attgcgtatt tcagcggtac tgcttcagcc attcttaaca aaaacacctg aaaaaatgtt 46681 cgagcagctg ggcattactg atgaatcttt aaaagcttgg gacagcatta cagctttcgg 46741 ccagctgaaa gatacaaaag tacaaaaagg cgagccattg ttccctcgtt tagaggcaga 46801 agaagaaatt gcttacatca aagggaaaat gcaaggttca gcaccagcga aagaagaaac 46861 aaaagaagaa gagcctcaag aggtcgatcg tttacctgaa attacgattg atcaatttat 46921 ggatgtagag cttcgcgtag ctgaggtcat tgaggcagag ccagtgaaaa aagcagaccg 46981 tttattgaag ctgcagcttg atcttggttt tgaaaagcgc caagtggtat ccggcattgc 47041 gaagcattat acgcctgaag agcttgttgg aaaaaaactc gtttgtgtaa caaatctaaa 47101 accggttaaa ctcagaggag agctttctca aggtatgatc cttgcaggag aagcagacgg 47161 cgttttaaag gtcgtatcta tcgatcagtc gttaccaaaa ggcacaagaa ttaaataatg 47221 ataaacaaaa ggtgtttcac gtgtaacaat tcgtcgaaca ccttttgtgt ttcgacaaga 47281 aaggagtttt tcacttatgt tgtttgacac tcacgcgcat ttaaatgcag aacaatatga 47341 tactgatctt gaagaggtta ttgaacgggc aaaagctgaa aaagttgaac gaattgtcgt 47401 agttggtttt gaccgtccga cgattacccg tgcgatggaa atgattgagg aatatgattt 47461 tatttatgca gccattggct ggcaccctgt tgacgctatt gacatgacag aggaagactt 47521 agcgtggatt aaagagcttt ctgctcatga gaaagtggta gcgatagggg aaatgggact 47581 ggattatcat tgggataaat cacctaaaga tattcaaaaa gaggtgttta gaaatcaaat 47641 cgccttagcg aaagaggtca atttgcctat tatcattcat aaccgtgatg caacggagga 47701 tgtcgtgacc attttgaaag aggaaggcgc agaagctgtg ggcggaatca tgcactgctt 47761 tacaggaagt gcggaagtgg caagagaatg catgaaaatg aatttttatt tatcatttgg 47821 gggaccggtg acatttaaaa atgcgaagaa accgaaggaa gtagtgaagg aaattcccaa 47881 tgaccggctg ctgattgaaa cggactgccc gtttctcaca ccgcaccctt tccgcgggaa 47941 aagaaatgag ccaagctatg tgaaatatgt ggcagaacaa atcgccgaat taaaagaaat 48001 gacctttgaa gagattgctt ccatcacgac tgaaaatgcg aaaagacttt tccgtataaa 48061 ctgacaaaaa acgctagcgg gttttgtaag agcttgtccc ttacagcgtt tttctataaa 48121 agttctacat gctttcttct cctcatagga taggtttgtc gacaagtctt tcttccgttt 48181 ctcagtgtat ttcaggataa tgaagaggac actgagcttt tgggagaaag agaagggagg 48241 gttgacagcc ttttagatac tctatataat ctctccgagg agaaggaggc gtttttcatc 48301 acacaaaaaa tgaaaaagct gttttccgta aagcttagca aaagcaaagt cattctggtt 48361 gctgcttgtt tgcttttggc aggaagcggg actgcgtacg cggctcatga gctgacgaaa 48421 caatcagtct cagtttctat caatggcaaa aagaaacata tacgcacaca tgcaaataca 48481 gtcggtgatc ttttggagac gcttgatata aagacaagag acgaagacaa gatcacacct 48541 gctaaacaga caaagataac agcagacatg gacgttgtgt atgaggctgc aaaacctgtg 48601 aagcttacaa taaacgggga agaaaagacg ttatggtcaa cagcaaaaac ggtcggtgca 48661 ttactggacg aacaagatgt tgatgtgaaa gaacaagatc aaattgatcc cgcaatagat 48721 acagatattt cgaaagacat gaagattaac atagagcccg catttcaggt tactgtgaat 48781 gatgcaggga aacaaaagaa gatctggacg acttcgacta cggtcgctga ctttttaaaa 48841 cagcaaaaga tgaacataaa agacgaagat aaaatcaagc ctgcgttaga tgcaaagctg 48901 acgaaaggaa aggctgatat tacaattact cgtatcgaaa aggtcaccga tgtagttgaa 48961 gagaagattg cgttcgatgt gaaaaagcaa gaagacgctt ctcttgaaaa agggaaagaa 49021 aaggtcgtcc aaaaaggaaa agaaggcaag ctaaaaaaac atttcgaagt cgttaaagaa 49081 aacggtaaag aagtgtccag agagcttgta aaagaagaaa cagctgaaca aagcaaagat 49141 aaagtgattg ctgtcggcac aaagcaaagc agtccaaaat ttgaaacggt cagtgcttca 49201 ggtgattcaa aaacagttgt gtcccgcagc aatgaatcaa caggcaaagt catgactgta 49261 tcatctacgg cttatacggc aagctgcagc ggttgttcag gacatacagc gacaggcgtc 49321 aatttaaaaa ataatccgaa tgccaaagtc atcgctgtgg atccaaatgt cattccgcta 49381 ggctccaaag tccacgtgga aggctatgga tatgccattg ctgcagatac cggttcagcg 49441 attaaaggga acaagataga cgtctttttc ccagagaaat catcggcgta ccgatgggga 49501 aataaaacag tcaaaattaa aatcttaaat tagtatatac ttatgtattc agagggtttt 49561 gcgccctctg tttttttcgt tataatagac aaagtgcatt ttctgcttat tagacgctcg 49621 atataagaaa aagtttcatg aatatacaaa agtttttatt ttgtcttgga ggaaataatg 49681 aaaattaaag agatcattgt ggtcgagggg cgtgacgata cggcccgcat caaattggct 49741 gttgatgcag acacaattga aacaaatggt tcagccatcg atgatcatgt gattgaccaa 49801 atccgtttgg cccagaagac gagaggcgtc attattttaa cggatccgga ctttccggga 49861 gagaagattc gcaaaaccat ctcagaggct gtacccggct gtaagcatgc atttttgcca 49921 aaacatcttg ccaaacctaa aaacaagcgg ggaattggtg tggagcatgc atcggttgaa 49981 agcattaggg catgtttaga aaatgtgcat gaggagatgg aagcgcagcc gagtgacatt 50041 tcagctgagg atttgattca tgccggacta ataggcgggc ctgcggccaa atgccgccgg 50101 gaacgactgg gtgatctgtt gaaaatcggc tatacaaatg gcaaacagct tcaaaaacgg 50161 ctgcaaatgt ttcaaattaa aaaaagtgat tttatgagtg cgctcgatac cgttatgcgg 50221 gaggaacaga atgaataaag atattgcgac accgattaga acgaaagaga tactgaagaa 50281 atacggtttt tcttttaaaa agagcttagg acagaatttc ttaattgata cgaacatttt 50341 aaacagaatt gttgatcacg cggaagtgac ggagaaaaca ggtgtcattg aaatcggccc 50401 gggaatcggg gctttaaccg aacagcttgc caagcgggcg aaaaaggtcg tggcatttga 50461 gattgaccag cgattattgc cgattctgaa ggatacactg tcaccttacg aaaatgtcac 50521 tgtcattcat caggacgtgt taaaggctga tgtcaaatca gtcattgaag aacaatttca 50581 agattgtgat gagatcatgg tagttgccaa ccttccttat tacgtaacaa caccgattat 50641 catgaaactg cttgaagaac atcttccgct gaaagggatt gtggttatgc tgcaaaaaga 50701 agtggctgag cgcatggcgg ctgatccttc atctaaggaa tacggctcgc tttcaatcgc 50761 ggtgcagttt tatacagaag ccaaaacggt gatgatcgtc ccgaaaaccg tatttgttcc 50821 tcagcctaat gtcgattccg cagtcattcg tctgattctc cgagacggcc cggcagtgga 50881 cgtggaaaac gaatcctttt tctttcagct catcaaggca agctttgcac agcgccgtaa 50941 aacgctgctc aataacttag ttaacaatct gcctgaagga aaagcacaaa aatcaacgat 51001 tgaacaagtg ctcgaagaaa caaatattga cggtaagcgc cgaggtgaat ccctgtctat 51061 tgaggaattc gcagcgctgt ctaacggatt gtataaagcc cttttctaaa agggcttttt 51121 gttttgcgca ccacatggac tgccgctaca taggctagag aaggaccttt cattcaatga 51181 taagaaaaaa cttggactca gcgaaaaaag gcgctttctc aaggctcttt ctttcatgat 51241 gaggcttagt ctatgtgtgg agtgaggaac gtgcaatttc aaatagggga tatggtagcc 51301 agaaaatcct atcagatgga tgttttgttt cgaattatag gaatagagca aacaagcaaa 51361 ggaaattcaa ttgccatttt gcatggagat gaagtcaggc tgattgctga ttcggatttt 51421 tctgatctgg tggcagtgaa aaaggatgag cagatgatgc ggaaaaagaa agatgagagc 51481 agaatgaatg agtcgctcga attgctccgc caagattata agctgctcag agaaaagcag 51541 gagtactatg cgacaagcca atatcagcat caggagcatt atttccatat gccgggcaaa 51601 gtgcttcatc tggatggtga cgaagcatat ttgaaaaaat gcctgaatgt ctataaaaaa 51661 attggagtgc cggtctatgg catccattgc catgaaaaga aaatgtctgc ttctattgaa 51721 gtattgctcg acaaatatcg acctgacatc ctggtgatca cagggcatga tgcgtactcg 51781 aagcaaaagg gcggtattga tgatttgaat gcgtacagac attctaagca ctttgttgaa 51841 acagttcaaa cagcccgaaa aaagatccct cacttagatc agcttgttat ttttgcgggg 51901 gcctgccaat cccattttga atcactcatc agagcgggtg cgaattttgc aagttcaccg 51961 tcaagagtca atattcatgc gcttgatccg gtatatatcg tcgcgaagat cagctttacg 52021 ccgtttatgg aacggattaa tgtatgggaa gtgctccgta atacgctgac aagagagaaa 52081 gggcttggag gtattgaaac aagaggagtt ctgagaattg gtatgcctta taagtccaat 52141 taacagttga aaacctgcat aggagagcta tgcgggtttt ttattttaca taatgataca 52201 taatttaccg aaacttgcgg aacataattg aggaatcata gaattttgtc aaaataattt 52261 tattgacaac gtcttattaa cgttgatata atttaaattt tatttgacaa aaatgggctc 52321 gtgttgtaca ataaatgtag tgaggtggat gcaatggcga agacgttgtc cgatattaaa 52381 agatcgcttg atgggaattt aggtaaaagg ctgacgttaa aagcaaacgg tggccgccga 52441 aaaacgattg agcgttcggg cattttagct gagacgtacc cttctgtttt tgtgatacaa 52501 ctagatcaag acgagaactc gtttgaaaga gtttcataca gttatgctga tattttgact 52561 gagactgttg agctgacatt taatgatgac gccgcaagct cagtggcatt ttaacgggca 52621 gtgaaccttt tgtttactgc tttttgtttt gccctttttt ggtttccaat aattttaacg 52681 aaagttccat ctgatttaac aaaagataaa acagtcacat attatcgtga cgtgcacgaa 52741 tggctatcac ttctaaaaaa ggagttgttt cgtttgggca gacgtcgtgg agttatgtca 52801 gatgagttta aatatgagct ggctaaagac cttggttttt atgacacagt aaaaaatgga 52861 ggctggggtg aaattcgggc ccgcgatgcc ggtaacatgg tgaagcgtgc tattgaaatc 52921 gccgaacagc aaatggctca gaatcagaat aaccgataag gatgtgaccc gggggacgtg 52981 ctgttccctg gtttttttat tttggatata aatacataat gggctgaata tggatatgtt 53041 catcctgtac ttcaaatgtg atacaatgtt catacttatg tttagatgga gaagtaggtg 53101 aaagctatgc gtattttaga aaaagcgcca gctaagatca atctgtcact tgacgtcacc 53161 cgaaaacgcc cggatggcta tcatgaagtc gaaatgatca tgacgacaat tgatttagct 53221 gatcgaattg aattgacgga gcttgcagag gatgaagtga gggtttcctc ccacaaccga 53281 tttgtgcctg atgaccaaag aaacttagct tatcaggctg ccaagctgat caaggacaga 53341 tacaacgtga aaaagggagt ttccatcatg attacgaagg taattccggt ggctgccggt 53401 cttgccggcg gaagcagtga tgcggcggcg acactcagag ggctgaacag actgtggaat 53461 ttaaatctgt ccgcggaaac gcttgctgag cttggagcgg aaattggctc tgacgtttca 53521 ttttgtgtct atggcggaac tgcattagca acagggcgcg gcgagaaaat taaacatatc 53581 agcacgcctc cgcactgctg ggtcatttta gcgaagccga caatcggtgt ttcaactgct 53641 gaagtgtaca gagcgctgaa actggatggt atagagcatc ccgatgtaca aggcatgatc 53701 gaggcgatag aagaaaagag ttttcagaag atgtgcagcc ggttaggcaa tgtgcttgaa 53761 tctgttacac tcgatatgca tcctgaagtt gcgatgatca aaaaccagat gaaacgcttt 53821 ggtgcagatg ccgtgttaat gagcgggagc ggcccgacag tgtttggact ggttcagtat 53881 gagtcgaagg tgcagagaat ttataacggg ttaagaggct tctgcgatca agtttatgcg 53941 gtgagaatga tcggcgaaca gaacgctctt gattaaatcc gtatgttaag ttatattgat 54001 cttaaaatat tcggattttg ggggtgagtt catgaagttt cgtcgcagcg gcagattggt 54061 ggacttaaca aattatttgt taacccatcc gcacgagtta ataccgctaa cctttttctc 54121 tgagcggtat gaatctgcaa aatcatcgat cagtgaagat ttaacaatta ttaaacaaac 54181 ctttgaacag caggggattg gtactttgct tactgttccc ggagctgccg gaggcgttaa 54241 atatattccg aaaatgaagc aggctgaagc tgaagagttt gtgcagacac ttggacagtc 54301 gctggcaaat cctgagcgta tccttccggg cggttatgta tatttaacgg atatcttagg 54361 aaagccatct gtactctcca aggtagggaa gctgtttgct tccgtgtttg cagagcgcga 54421 aattgatgtt gtcatgaccg ttgccacgaa aggcatccct cttgcgtacg cagctgcaag 54481 ctatttgaat gtgcctgttg tgatcgttcg taaagacaat aaggtaacag agggctccac 54541 agtcagcatt aattacgttt caggctcctc aaaccgcatt caaacaatgt cacttgcgaa 54601 aagaagcatg aaaacgggtt caaacgtact cattattgat gactttatga aagcaggcgg 54661 caccattaat ggtatgatta acctgttgga tgagtttaac gcaaatgtgg cgggaatcgg 54721 cgtcttagtt gaagccgaag gagtagatga acgtcttgtt gacgaatata tgtcacttct 54781 tactctttca accatcaaca tgaaagagaa gtccattgaa attcagaatg gcaattttct 54841 gcgttttttt aaagacaatc ttttaaagaa tggagagaca gaatcatgac aaaagcagtc 54901 cacacaaaac atgccccagc ggcaatcggg ccttattcac aagggattat cgtcaacaat 54961 atgttttaca gctcaggcca aatccctttg actccttcag gcgaaatggt gaatggcgat 55021 attaaggagc agactcatca agtattcagc aatttaaagg cggttctgga agaagcgggt 55081 gcttcttttg aaacagttgt aaaagcaact gtatttatcg cggatatgga acagtttgcg 55141 gaagtaaacg aagtgtacgg acaatatttt gacactcaca aaccggcgag atcttgtgtt 55201 gaagtcgcga gactcccgaa ggatgcgtta gtcgagatcg aagttattgc actggtgaaa 55261 taataagaaa agtgattctg ggagagccgg gatcactttt ttatttacct tatgcccgaa 55321 atgaaagctt tatgacctaa ttgtgtaact atatcctatt ttttcaaaaa atattttaaa 55381 aacgagcagg atttcagaaa aaatcgtgga attgatacac taatgctttt atatagggaa 55441 aaggtggtga actactgtgg aagttactga cgtaagatta cgccgcgtga ataccgatgg 55501 tcgcatgaga gcgattgcat ccatcacgct ggatcacgaa tttgttgtac atgatattcg 55561 tgtgattgat ggaaacaatg gtcttttcgt tgcgatgccg agtaaacgca cccctgatgg 55621 agagttccgc gatattactc atcctattaa ttcaagcacg cgaggaaaga ttcaagatgc 55681 cgtgttaaat gagtatcatc gtctgggtga cactgaagca ttagaattcg aagaagctgg 55741 agcttcttaa aaaataacca aaaagcaagg actgctgaaa gggctgacat aagccttttg 55801 ccggcggtcc ttttttaatt ctgatttttc aaacttagtt gcactcaata gaaaattctt 55861 gcacttcatg aagtctcctt gaaatcagaa gatatttagg atatattttt ctatggataa 55921 aagggatatt ggaggccaat aaatggataa gcggtttgca gttgttttag cggctggaca 55981 aggaacgaga atgaaatcga agctttataa agtccttcat ccagtttgcg gtaagcctat 56041 ggtagagcac gtcgtggacg aagccttaaa attatcttta tcaaagcttg tcacgattgt 56101 cggacatggt gcggaagaag tgaaaaagca gcttggtgat aaaagcgagt acgcgcttca 56161 agcaaaacag cttggcactg ctcatgctgt aaaacaggca cagccatttc ttgctgacga 56221 aaaaggcgtc acaattgtca tttgcggaga tacgccgctt ttgacagcag agacgatgga 56281 acagatgctg aaagaacata cacaaagaga agcgaaagct acgattttaa ctgcggttgc 56341 agaagatcca actggatacg gccgcattat tcgcagcgaa aacggagcgg ttcaaaaaat 56401 agttgagcat aaggacgcct ctgaagaaga acgtcttgta actgagatca acaccggtac 56461 gtattgtttt gacaatgaag cgctatttcg ggctattgat caggtgtcta atgataatgc 56521 acaaggcgag tattatttgc cggatgtcat agagattctt aaaaatgaag gcgaaactgt 56581 tgccgcttac cagactggta atttccaaga aacgctcgga gttaatgata gagttgctct 56641 ttctcaggca gaacaattta tgaaagagcg cattaataaa cggcatatgc aaaatggcgt 56701 gacgttgatt gacccgatga atacgtatat ttctcctgac gctgttatcg gaagcgatac 56761 tgtgatttac cctggaactg tgattaaagg tgaggtgcaa atcggagaag atacgattat 56821 tggccctcat acggagatta tgaatagtgc cattggcagc cgtacggtta ttaaacaatc 56881 ggtagtcaat cacagtaaag tggggaatga tgtaaacata ggaccttttg ctcacatcag 56941 acctgattct gtcatcggga atgaagtgaa gatcgggaat tttgtagaaa ttaaaaagac 57001 tcaattcgga gaccgaagca aggcatctca tctaagctat gtcggcgatg ctgaggtagg 57061 cactgatgta aacctgggct gcggttcaat tactgtcaat tatgatggaa agaataagta 57121 tttgacaaaa attgaagatg gcgcgtttat cggctgcaat tccaacttgg ttgcccctgt 57181 cacagtcgga gaaggcgctt atgtggcggc aggttcaact gttacggaag atgtacctgg 57241 aaaagcactt gctattgcca gagcgagaca agtaaataaa gacgattatg tgaaaaatat 57301 tcataaaaaa taatcctaaa ttcggaggtt tatccatgtc taatcaatac ggagataaga 57361 atttaaagat tttttctttg aattcgaatc cagagcttgc aaaagaaatc gcagatatag 57421 ttggagttca attagggaaa tgttctgtca caagatttag tgacggggaa gtccaaatta 57481 atatcgaaga aagtattcgc ggatgtgatt gttacatcat ccagtctaca agtgaccccg 57541 ttaacgagca tattatggaa ctgctgatta tggtagatgc gttaaaacgc gcttctgcaa 57601 aaacgattaa cattgttatt ccttattacg gttatgcgcg tcaagacaga aaagcaagat 57661 cccgtgagcc aatcacagct aaacttttcg ctaacctgct tgaaacagcc ggtgcgactc 57721 gtgtgattgc acttgacctg catgcgccgc aaattcaagg attctttgat ataccgattg 57781 accacttaat gggtgttccg attttaggag aatattttga aggcaaaaat cttgaagata 57841 tcgtcattgt ttcaccagac catggcggtg tgacacgtgc ccgcaaactg gctgaccgac 57901 taaaagcgcc aattgcgatt atcgataaac gccgtccgcg tccaaacgtg gcggaagtca 57961 tgaatattgt aggtaacatc gaagggaaga ctgctatcct catcgatgac attattgata 58021 ctgcaggtac gattacactt gctgctaatg cgctcgttga aaacggagcg aaagaagtat 58081 atgcatgctg tacacaccct gtactatcag gccctgcggt tgaacggatt aataattcaa 58141 caattaaaga gcttgttgtg acaaacagca tcaagcttcc tgaagaaaag aaaattgaac 58201 gctttaagca gctttcagtc ggaccgcttc tggccgaagc gattattcgc gttcatgagc 58261 agcaatcagt cagctatctg ttcagctaaa ccatttttcg aggtttaaat ccttatcgtt 58321 atgggtattg tttgtaatag gacaactaaa acgacaagag gatggtgctg aatatggcaa 58381 ctttaacggc aaaagaaaga acggacttta ctcgttcgtc tcttcggaat atccgtactt 58441 caggacatgt tccaggtatc atatatggga aggatacggg taacaaacct gtgtcattag 58501 acagtgtgga gctcatcaaa acgctgaggg acgaaggcaa aaatgcagtc attacgcttg 58561 aggtcagcgg agaaaaacac tcagtcatgg taacagacct gcagacggac ccgctgaaaa 58621 atgaaatcac tcatgctgat tttcaagtag ttaatatgag tgaggacatt gaagtggaag 58681 ttccgattca tctgaccgga gaagccattg gagtgaaaaa cggaggcgta ctgcagcagc 58741 cgttatatgc acttactgta aaggccaagc caaaagccat tccgcaaacg attgaggctg 58801 atatttcaag cctcgatgta aatgaagtac tgacgattgc ggatttgcct gctggcggtg 58861 actactcctt taatcatgaa tcagatgagg ttgtggcttc aatccttcct ccgcagcagc 58921 aggaagcagc tgaggtcgat gaagaggaat ctgccgatgc tcagcctgaa ggtgaaaacg 58981 aacaataata gcttaaggcg taaccctccc gcggttacgt cttttgtgct agaatgagaa 59041 gaattatagc ccgtttatga agacgggagt tatgtgacta agggaggatt cgccatgctt 59101 gtgattgccg gtctcggaaa cccggggaag aactatgaaa atacacggca taatgtcgga 59161 tttatggtga tagatcagct tgcaaaggaa tggaatatag agctgaatca aaataaattt 59221 aacggattat acggaaccgg atttgtttcc ggcaaaaagg ttctacttgt taaaccgctt 59281 acatatatga atttatcagg agaatgtttg cggcctttaa tggactacta tgatgtcgat 59341 aacgaagatt tgacagtcat ttacgacgac cttgaccttc cgactggcaa gatccgttta 59401 agaacgaaag gaagcgccgg agggcacaat ggcatcaaat cactgatcca gcatcttgga 59461 acgtccgagt ttgaccgtat ccgcatcgga atcggccggc ctgtaaacgg catgaaggtc 59521 gttgattatg tgttaggctc ctttaccaag gaggaggcac ctgagatcga agaagcggtt 59581 gataaatctg tgaaggcttg tgaggcttct ttgagtaaac cgtttttaga agtcatgaac 59641 gaatttaacg caaaggtata aaatgtaaca acaaagtcca tactacacca aaatgacttt 59701 ttcatcagga ggacccttgt atggctttgc attattattg tcgtcattgc ggagtgaaag 59761 taggcagtct cgaatcttca atggtatcga cagactcact tggatttcag cacttaacaa 59821 atgaggaaag aaacgatatg atttcttata aagaaaatgg agatgtccat gttttgacga 59881 tatgtgaaga ctgccaagag gcgcttgacc gaaatccgca ttaccacgaa tatcacacat 59941 ttattcaata aaaagctttg gtgtagacac tagaccaaag cgtttttctg ttctcgcagg 60001 aaacagagag gaggggccat atggacaaca ttcaaacctt tataaaagaa agcgatgact 60061 ttaaatccat catcaacggt ttacacgagg gcctgaagga acagctgctc gcgggtctgt 60121 cgggttccgc gcgttctgtt tttacttctg ctctggctaa tgaaacgaat aagcctatct 60181 ttctcatcac ccataactta tatcaagccc agaaagtaac agatgatctg acttcacttc 60241 tagaggatcg gtctgtcctt ttgtaccccg tcaatgaact catttcatca gaaatcgcag 60301 ttgcaagccc tgaattgcgg gcgcagcgat tagatgtcat taatagacta acgaatggag 60361 aagcgccaat tgtcgttgct ccggtagctg caatcagaag aatgctgccg cctgttgagg 60421 tgtggaaaag cagccagatg ctcattcaag taggccatga tattgaacct gaccagcttg 60481 cctcacggct ggtagaggta gggtatgagc ggtctgatat ggtttctgcg cccggggaat 60541 tcagtattcg cgggggaatc attgacattt atccgctgac ttcagagaat ccggtgagaa 60601 ttgaactttt tgacaccgag gtggattcaa tccgcagctt taattcagat gatcagcggt 60661 caattgagac ccttacctcg atcaatatcg gtcccgcgaa ggaattaatt atcagaccgg 60721 aagaaaaagc gcgggcgatg gagaaaatcg atagtggtct tgccgcgagc ttgaaaaaat 60781 taaaggctga caaacaaaaa gaaatacttc atgcgaatat ttctcacgat aaagaacgct 60841 tgtctgaagg ccagacagat caggagctcg tgaagtatct ctcatatttc tatgaaaagc 60901 ctgctagttt actagattat acacctgata atacacttct gattttggat gaagtcagtc 60961 ggattcatga gatggaagaa cagcttcaaa aagaagaagc ggagtttata acaaatcttc 61021 ttgaggaagg gaagattttg catgacattc gtttgtcatt cagcttccaa aaaatagtgg 61081 ctgagcaaaa acggcctctg ctgtactact ctttattttt gcggcatgta caccatacga 61141 gcccgcaaaa tatcgtcaat gtgtcaggcc ggcaaatgca gagtttccat ggccaaatga 61201 acgtgcttgc gggcgaaatg gagcgtttta aaaaatcaaa tttcactgtt gtgttcttag 61261 gagcaaacaa ggaacgtacg cagaaattgt catctgtttt ggctgattat gatatcgagg 61321 ccgccatgac agacagcaaa aaagcgcttg ttcagggaca ggtctatatc atggaaggcg 61381 agctccaatc gggatttgag ctgccgttaa tgaagcttgc cgttatcacg gaagaagaac 61441 tgttcaaaaa ccgtgtaaag aagaagccgc gaaaacagaa gcttaccaat gcagagcgca 61501 tcaaaagcta ttctgagctt caaattggag attatgtcgt tcatattaat cacgggatcg 61561 gaaaatacct ggggattgaa actcttgaaa tcaacggcat tcataaagac tatttaaata 61621 tacattatca gggcagtgac aagctttacg tccctgtaga acaaattgat caggtccaaa 61681 aatatgttgg ctccgaagga aaagagccaa agctgtataa attaggcgga agtgaatgga 61741 agcgggtcaa gaaaaaagta gagacatccg ttcaggatat tgctgatgac ttaattaagc 61801 tgtatgccga aagagaagcg agcaagggct atgcgttttc tcctgaccat gagatgcagc 61861 gtgaattcga atcggctttc ccttatcaag agactgagga tcagctccgt tctattcacg 61921 aaatcaaaaa agacatggaa agagaacgtc cgatggaccg cttgctgtgc ggagatgtgg 61981 gctacggtaa aacagaggtt gccatacgtg ccgcgtttaa ggcgatcggt gacggaaagc 62041 aggtagctct gctcgttccg acaaccattt tggcacagca gcactatgaa accataaaag 62101 agcgcttcca ggactatccg attaatatcg gccttctcag caggttcaga acgagaaaag 62161 aagcaaacga aacaatcaaa gggctgaaaa atggaacggt tgatatcgtc atcgggacgc 62221 atcggctgct atcaaaggat gtcgtgtata aagacttagg gctcctcatc attgatgaag 62281 agcagcgttt cggtgtaacc cataaagaaa agatcaagca aataaaagcc aatgttgatg 62341 tattaacgtt aacagcaacg ccgattccgc gtacgctgca tatgtctatg cttggcgtaa 62401 gggacctttc agtcatcgag actccgccgg aaaatcgctt ccccgtacag acgtatgttg 62461 tggaatataa cggcgctctt gtcagagagg cgattgaacg tgagcttgca cgcggaggcc 62521 aggtctattt cttgtacaac cgggtagagg acattgagcg gaaagcggat gaaatttcaa 62581 tgctagtccc tgacgcgaag gtagcatatg cgcatgggaa aatgacagaa aatgaattag 62641 aaaccgttat gctaagcttc cttgaaggag aatcagacgt tctcgtcagc acaaccatta 62701 tcgaaactgg cgtggacatc ccaaacgtca atacgctgat cgtatttgac gccgacaaga 62761 tgggactttc tcagctttac cagctgcggg ggcgtgtcgg ccgttctaac cgtgtggcgt 62821 atgcgtactt cacgtatcgc cgggataaag tgctgacaga agtggctgaa aaaaggctgc 62881 aggctattaa agaattcaca gagttaggtt ccggttttaa aatcgcaatg cgtgacttaa 62941 cgattcgcgg agccgggaat cttcttggtg cccagcagca tggcttcatc gattcggtcg 63001 gatttgacct ctattcacaa atgctgaagg aggccattga ggagcgtaaa ggagacacag 63061 cgaagacaga gcagtttgaa acagaaattg atgtcgagct tgatgcgtat attccggaaa 63121 cttatattca agacggcaaa cagaaaattg atatgtataa acgcttcagg tctgtggcga 63181 caatcgaaga gaagaatgag cttcaagatg aaatgatcga ccgctttgga aactatccaa 63241 aagaagtcga atacttgttt actgttgcag aaatgaaagt ctatgcgaga caggaacgtg 63301 tcgagctgat taagcaggat aaagatgctg tcagattgac gatttctgaa gaagcaagtg 63361 ctgaaattga cgggcagaag ctgtttgagc ttggcaatca atatggcaga caaatcggac 63421 tgggaatgga agggaaaaaa ctcaaaatct ccatacagac gaaaggccgt agtgctgatg 63481 aatggctcga caccgtgctg ggcatgctga agggcttaaa agatgtgaaa aagcaaacca 63541 tttcatcaac gtaaattttg ttactctctg gtgtatatta catttgatgt gacggatact 63601 aatttcaagc gaggcggaag gtacataaag taactgcttt aggtctttcc cacatgtata 63661 taccatcaaa tgaaagagag gcaccagaga tgaaagcaac cggtatcgta cgtcgtattg 63721 atgacttagg tcgggtcgtg attcctaaag aaattcgaag aactctgaga atcagggaag 63781 gcgatccgct tgagattttt gtagatcgtg acggagaagt gattttgaaa aagtactctc 63841 cgatcagtga gcttggagac tttgcaaagg agtatgcaga cgcgctttac gacagcctcg 63901 gccattcagt gctgatttgt gatcgtgatg tatatattgc cgtgtccggc agctccaaaa 63961 aagattactt aaacaagtca atcagcgaaa tgctggaaag aacaatggat cagcgcagct 64021 ccgtgcttga gagtgatgcg aaatcagtac agcttgtgaa tggaattgat gaggacatga 64081 attcttatac tgtaggccca attgtggcga acggtgatcc gataggtgct gtggtgatct 64141 tttcaaaaga tcagacaatg ggcgaagtag agcataaagc cgttgaaaca gcagctggat 64201 ttttggctcg tcaaatggaa cagtaggtct tattcctttc ttcgaaaata ggtatgtaaa 64261 gaacagctct ccttgggacg ctgttctttt tcatgcgtgc cgaaaaagga atccaagggt 64321 tgggatgtgg tataataacc tcgtttttat ttgtgccgcg gtaatacgtg aaccgtattg 64381 cccctgacgt tgggaaggag cttttggatg gacgattcaa taggcgttaa acggcattgg 64441 atttggcagg gggcttttgt tttaattctg gcaggcgtca tcacaaaaat tttaagcgct 64501 gtttacagag tcccgtttca aaacattgtc ggcgatgttg gattttatat atatcagcag 64561 gtatacccct ttcttggtat tgcggtcatg ctgtccacat caggatttcc agtcattatt 64621 tcaaagctga tgaatgatta tagtgaaaaa aatcatcaca ccatattaaa aatatcagcg 64681 ttgtttttgt ctttaatcgg tattttatta tttctttgtt tatatctggg tgctgttcct 64741 attgcactct ttatgggaga ttcgcatcta gccgtgttaa ttcaagtggc cgcatacgcg 64801 tttctgcttt tcccatttgt cgcgttgcta agaggcggtt ttcaggggcg gcacgaaatg 64861 ctcccttcag ccttatcaca gatgacagag cagtttctgc gtgttgcggt gctcttgggt 64921 ttatcatttt ggctcgtgaa aaagggagcc tcgctttata ctgcgggagc ggcagccgct 64981 tcaggctctc ttgccggaag tttggttgca ttgataatac tggggttttt ttggttcaaa 65041 acgaaaagag acaaccaaac ggataggcaa aacgaaaatg tcatcacaac aaaagaattg 65101 acgaaaaaac tgcttttata ttcggtcaca atttgtgtaa gcagtttgct gcttttgttt 65161 atccagcttg ttgatgcttt gaatttatat gcattgcttt cgggtggtga ggcaagcgaa 65221 gaagcaaaat gcctaaaggg gatctatgat cggggacaac ccttgttgca gctcggttca 65281 gtttttgccg taagcattgc gacgtcactc gttccgtata tttctatggc tgtaaaaaac 65341 aaagagctga agatcatgaa agaaaaaatc acgtcatctt tgaaactatg ccttgtgctc 65401 ggtacaggcg catcggctgg gttgatttgc attctaaagc cggtaaatat catgctgttt 65461 caaaatggag aagggacagg tgcgttacaa gtatttagct gctccatttt gtttgcatcc 65521 ttggcggtaa cggcagcggc agtcttacag ggagcgggat acacagtttt tcctgcgata 65581 gcggtgggcg cgggtgttgc ggtgaaatgg gtgttaaaca cacttttggt tccgcgctat 65641 gggattgaag gcgcatcgct tgcgacagcg gcttcctttg cggctgtcgc cggccttaac 65701 ttgtatcagc ttcggcaaaa ggaatggctc gataagctta gaggcgtttt gattccgatt 65761 attggatctg ctcttttgat gtcagctgtt ttgcttgcgt atacgcgtct ctggactttc 65821 ttgtttcctg caacaggaag aggagcggct gtgattgaga gtctttctgc tgttgccatt 65881 ggtggcgcgg tgtttattta ttgtatgatg agattgggaa tatttacaga tgaagagctg 65941 aacagtgtgc cattcggcag caagttaagc aaattcatga gaaggagaga acaaaatggc 66001 gggtaaaatt acagtcgtcg gacttggtgc cggagacatg gaccaattga caattggtat 66061 acacaagctg ctgacgaagg cagatacgct gtatgtcaga accaaggatc atcctttaat 66121 tgaggagctt gaaaaagaaa cgaagaacat ccgtttcttt gatgatatat atgagaaaca 66181 tgatcagttc gaggcggtat atgaagaaat tgcagatatc ctctttgaag cggcgcggcg 66241 tgaggacgtg gtttacgctg tgccgggaca cccttttgtc gcagaaaaaa cagttcagct 66301 gctgacggag cggcaggaaa aggaaaacgt tcaagtgaaa gtcgcggggg gacaaagttt 66361 ccttgatgcc acattcaatg tcttgcaaat tgacccgatt gaaggttttc aatttgtgga 66421 tgccggcaca ttgtccgcgg atgagcttga gctcagacat catctgatca tatgtcaggt 66481 ttacgaccaa atgacggctt ctgaagtcaa gctgacattg atggagaagc tgcctgatga 66541 ttatgaggtc gtcattgtga ctgcagcagg cagccgtggc gaggagatca ggacagtgcc 66601 attatttgag ctggaccgca atgtcgcttt gaacaactta acaagtgtgt atattccgcc 66661 gattaaagaa gagaagctgc tttatcacga attctccacg ttccgaagca tcatcagaga 66721 gcttcgcgga cctaatggat gtccgtggga taaaaagcag acgcatcagt cattaaagca 66781 gtacatgatt gaagaatgtt atgagcttct cgaagctatt gacgaagaag acacagacca 66841 tatgatcgaa gagcttggcg acgttttgct tcaggtcttg cttcacgcgc aaattggtga 66901 agatgaaggt tatttcacaa ttgatgatgt cataaaagga atcagtgaaa aaatggtccg 66961 aagacatccc catgtgttta aagatgttaa ggttcaggat gaaaacgatg ttttagccaa 67021 ttgggaagat ataaaaaagg ccgaaaaaaa tacatctgaa tcatcattac tagacagcgt 67081 accgaaaacc cttccagctc tttcgaaagc agctaaattg cagaaaaaag cagcgaaggt 67141 cggttttgac tgggaagacg tcagcgatat ttgggaaaag gtaagtgagg aaatgaagga 67201 attttcttct gaggtttctg aagctcctca cgaacacaat cttaaagctg agtttggcga 67261 cattttgttc gcgctggtga atgtagcccg cttctacaaa atagagccag aggaagcgct 67321 gaccatgact aatgacaaat tccggagacg gttctcgtac attgaggaaa cagcgaagga 67381 agagggagtc gagttggctg atatgtccct tgaggacatg gacaaactgt ggaatgaagc 67441 aaaagaaact gagaggagat catagatatg agattagata aatttttgaa agtatcacgg 67501 ctgatcaaac ggcgtacact agcgaaggaa gtagctgacc aaggacgaat ctctattaac 67561 ggaaaccaag ctaaagctag ctctgacgta aaaccgggag atgaactaac ggtccgcttc 67621 ggccaaaagc ttgtaacggt tcaagttaat gaattgaaag acacgacgaa aaaagaagaa 67681 gctgcaaaca tgtacacgat tctaaaagaa gaaaaactcg gcgaataggc ttgttctaaa 67741 aaaacccccc acctcataca atgcagtaat aatgctaaaa gtatcgagga tatgggggct 67801 gaatagatga attcatatta tgatcaaaaa ggttcttcgt ctgttccgga acagcatgat 67861 gtgacaatga aaggccggaa gcatttagat atttctgggg ttaagcatgt ggagagtttt 67921 gataacgaag aattcctgct ggaaacggtg atgggaatgc tctccgtcag aggccaaaac 67981 ctgcagatga aaaatcttga tgtggaaaaa gggattgttt cgattaaagg cagggtattt 68041 gatttagtgt acttagacga acaacaaggg gataaagcta aagggttttt tagcaagttg 68101 tttaaatgac gctgacgaca caattctata caatgctagc gatgtccggt atgggtctct 68161 ggcttggtgc ttcgcttgat acataccggc tctttgtcat tcgtgccaaa acagccagat 68221 ggctattatt tattcatgat attcttttct ggattatgca agggctgctt ttcttttatg 68281 tcttgcttca tgtaaatgag ggagaattca ggatttacat ctttttagcg gttctgctgg 68341 gcgttgcgac gtatcagagc ctttgcaaac gaatctatat aaaaatactg aaattcgtca 68401 tttaccttgt tgtttctgtt tatcaattct tcaaaaaact cattcagcac gtgttatttc 68461 gtcctattgt gtggacatgc ggagcgatca tctggctggc ggcattttta ttcaagaaaa 68521 catacagcct gataggtttt ctcctgctgt gtctatataa aatagtcatg gttctgtgtt 68581 ttccgatccg ttttatcgcg aaacaatgtt tgaaacttct tcctgtgaaa atgcgtctaa 68641 cttttagacg ttattttgaa aaaggtgcag gatttctcaa aaagaagaag aaactattga 68701 taaccataag aacgaccatc acacggtttt tgaagagatg aaaggaggac cgtctggttt 68761 gaatttttcc agggaacgaa cgataactga aatacaaaac gactataaag aacaagtaga 68821 acggcaaaat cagctgaaga aacgaagacg caaagggctg tacagacggt taactgtatt 68881 cggcgcccta gtattcctga cggcaattgt gctggcaagc tctgtatggt cccaaacatc 68941 ttcccttagt gcaaaagaag aaaagaaaga acagcttgaa aaagaactga aaagtttaaa 69001 gacaaaacaa acggatttaa aagaagaaat atccaaattg aaggatgagg attacgtcac 69061 agagcttgcc agaagggact tattcatgtc tggagacgga gaaattatct tcaatgtgga 69121 gaagaagagc aagtagcctt gttgacactt aaatttttat ttaggtataa ttaagcaaac 69181 gatcttttta taagcctaag gaggagcact ttttttatgt cgattgaagt tggcagcaag 69241 ttgcaaggga aaattacagg tattacaaat tttggagcat ttgttgaatt gcctggaggc 69301 tcaaccggtc tcgttcacat tagtgaggta gctgataatt atgtcaaaga cattaacgac 69361 cacttaaaag tcggcgacca agttgaagtg aaagtcatca acgttgaaaa agacgggaaa 69421 attggtttat ctattaaaaa agctaaagac cgtccgcaag ccagacctag aaatgatttc 69481 cgtccgaaag aatcttttga acagaaaatg aataagtttt taaaagacag cgaagatcgc 69541 ttgtcatctt taaaacgcaa tacggaatca aaacgtggag ggcgcggagc aagaagagga 69601 taacttgctg ctttctataa aataaatgaa gcatccgttc atcccgacgg atgctttttt 69661 attatcctca ttctctttaa gagtcagaaa attacaacat taaagtttct gttgacgaaa 69721 gagacaaacc tttgtattat ataacttgtg cttagaagca caaaacaata tggcggtgta 69781 gctcagctgg ctagagcgta cggttcatac ccgtgaggtc gggggttcga tcccctccgc 69841 cgctaccata tttgtttggc ccgttggtca agcggttaag acaccgccct ttcacggcgg 69901 taacacgggt tcgaatcccg tacgggtcat cctaacaaat cggtttctct tgcagaagcc 69961 gatttttttc atttttagac aacattccgg aaattctttt cataaacgaa tatcaaggca 70021 gaaaccgtcg aagatttctt tggtattgtt accttctttt gacaaaatcc tatctgtgct 70081 ttcgctataa tgacaggcaa cgaatataac aggtgggaga tgagaggaat ggaaaaagca 70141 gaaagaagag tgaacgggcc aatggcggga caagctttgg aaaaactcca atcgtttttt 70201 aacaggggca cgaagctggt gactcatcat ttgcattcac tgtttttcta taaaggattc 70261 atttatgttg tcatcggatt tttgcttgga cgggctttca tattatccga ggtgcttcct 70321 ttcgcacttc ctttctttgg agcgatgctt cttatcagaa gagacaaagc gttttatgcg 70381 gttttggctg tgcttgcagg tgcgctgacc atatctccaa agcactcatt gctcatactg 70441 gcggcattgc tggcattctt cgtattttct aaagtggctg ccttcattac cgacgatcgt 70501 gttaaagcgc tcccgattgt cgtgttcttc tccatggctg cagcaagagc cgggtttgtt 70561 tatgcccaaa atggcgtatt tacaacctat gattatgtaa tggctatcgt tgaggctgga 70621 ctatcgttta tcttaacact gattttcctt cagagccttc cgatttttac tgtgaaaaaa 70681 gtgaaacaat cattaaaaat agaggaaatc atttgcttta tgattcttat tgcctctgtt 70741 ttaacggggc tggctggctt gtcctaccaa gggatgcagg cagaacatat attggctcgt 70801 tatgttgtgt tgagtttttc ctttattggc ggagcaagca tcggctgtac ggttggggtt 70861 gtgaccggcc tgattcttgg cttggcgaat atcggaaacc tatatcaaat gagtctgctt 70921 gctttttccg gtttattggg cggtttgctg aaggaaggga aaaaagcggg tgcagcaatt 70981 ggtttgatcg ttggatcact tcttatatct ttatatggtg aaggctctgc cggtctgatg 71041 acaacgctct atgagtcatt aatcgcagtc tgcctgtttt tgctcacacc tcaatctatt 71101 acgaggaaag tggcgagata tattccggga actgtcgagc atcttcaaga gcaacagcaa 71161 tacgctagaa aaatccgtga tgtcactgct cagaaggtag accaattctc caatgtattt 71221 cacgcgctgt ctgaaagctt tgcaaccttt tatcaagcat cagacgaaca gacagatgac 71281 agcgaagttg atctgttctt aagcaaaatc acggagcatt cctgccagac gtgctacaag 71341 aaaaacaggt gctgggtaca gaactttgat aaaacatatg acttaatgaa acaagttatg 71401 cttgaaacag aggaaaaaga atatgcatca aaccgaaggc tgaaaaaaga gtttcaacag 71461 tattgttcta aatccaagca ggttgaagag ctgattgagg atgagctcgc acatcatcat 71521 gcccatttga cactcaagaa aaaagtccaa gacagcaggc gccttgttgc tgaacagctt 71581 ttaggcgttt ctgaggttat ggccgacttt tctcgggaaa taaaaagaga gcgagaacaa 71641 cactttctgc aggaagagca aatcatagaa gcgcttcagc atttcggaat tgagattcag 71701 catgtcgaga tctatagtct tgaacaagga aatatcgata ttgaaatgac cattccgttc 71761 agcggacatg gagaaagtga aaaaatcatt gctcctatgc tttctgacat tctggaggaa 71821 caaattcttg tgaaagccga acagcactct ccgcatccga atggatacag ccatgtcgcc 71881 tttggatcaa caaaatcata cagggtgtcc acgggagctg ctcacgctgc gaagggcggc 71941 ggccttgtct ccggtgacag ctacagcatg atggagcttg gagccagaaa atatgctgca 72001 gcaatcagtg acggaatggg caatggcgca agagcgcact ttgaaagcaa tgaaacgatc 72061 aagcttcttg aaaaaatcct tgaatcgggc attgatgaaa aaatagcaat taaaacgatc 72121 aacagcatac tgtctctaag gacaactgac gaaatatatt ccacgcttga cctatctatt 72181 atcgatcttc aagatgccag ctgtaaattt ttgaaggttg gatcgacgcc cagctttatc 72241 aaacggggtg accaggtcat gaaagttcaa gcgagcaatc tgccaatcgg tattattaat 72301 gaattcgatg tggaggttgt gagtgaacag ctgaaagcgg gtgacctctt aattatgatg 72361 agtgatggca tttttgaggg gcctaagcat gtggaaaatc acgacttatg gatgaagcgt 72421 aaaatgaaag ggttgaaaac aaatgacccg caggagattg ccgatttgct tatggaagaa 72481 gtcatccgca caagatccgg ccaaattgag gacgatatga ctgttgttgt cgtccggatt 72541 gatcacaata caccgaagtg ggcatccatt cctgttccgg caatctttca aaacaaacaa 72601 gaaatttcat aacgcttccg tataaatcaa atttcttctg gcgaagatgg gaatatatga 72661 atctgagaat cctcgtattc tccaggagga atgaatgtga acaacggaca tttaaatcaa 72721 attttgctga taacggatgg ctgctcaaac catggggaag acccgcttgc aatggctgct 72781 tttgctaaag agcaggggat tacggtaaat gtcattggta taatggaaga aaatcaaatt 72841 gaccctgagg caatgaagga agtcgaaggg attgcacttg ccggaggagg cgtgcaccaa 72901 gtcgtttatg catctcagct ttcacaaact gttcaaatgg taacaaagaa agcgatgacg 72961 caaaccttac aaggtgtagt caatcaagaa ctgaaacaga ttctcggaaa gaatgtggaa 73021 atggaagagc tttctccgga aaaacgcggc gaagtcatgg aagtggtaga cgagcttgga 73081 gaaacggtgc atcttcaggt tttggttctt gttgatacaa gtgcaagtat ggcgccaaag 73141 cttccaacag taaaagaggc gctgattgat ttgtctgtaa gcctcaattc ccgaattggg 73201 aataacgaat ttgcgatgtg tatatttccc gggaaaaaac aagaggtcga gcttgtgctg 73261 aactggacac cgaagctgca atctctttcc acactctttg caaagctttc gacaggcggc 73321 atcacgccga caggtccggc gattcgtgaa gcgacactgc agtttgaaaa aatacgctca 73381 agaaggggca tgctggcaga tgatgaacga cgctttgacg agtttggcat gtagcctcaa 73441 gccgggtacg acaatcaaag gcaagtggaa tggaaacact tatacattgc gtaaacagct 73501 tggtaaaggg gccaatggaa ttgtgtattt ggcagaaaca tcagatggac atgttgcctt 73561 aaaggtgagt gatgacagcc tgtctattac ttctgaagtg aatgtcttga aatctttctc 73621 aaaggcccag tccgttacga tggggccttc tttttttgat acggatgatg cctatattcc 73681 cagtgccaat acgaaagttt cattttatgc aatggaatac ataaaagggc cgctgctttt 73741 gaagtatgtc agtgataaag gagcagagtg gataccggta ttaatgattc agctgttatc 73801 cagcttatcg gtgcttcacc agcaaggatg gatattcggc gatcttaaac ctgataatct 73861 gatcgtaact ggtccgcccg caaggatccg ctgcattgat gtgggcggca cgacaaagga 73921 aggccgggcg ataaaagagt atacggagtt ttatgacaga ggctattggg ggtatggaac 73981 aagaaaggca gagccatcct atgatctgtt cgcagttgcc atgattatga tcaacagtgt 74041 gcataaaaaa gaatttaaga aaacgaacca gcccaaagaa cagcttaggt ctctcatcga 74101 aggaaacccg ctgcttcaaa agtataaaaa agcgcttttt tcagccttga acggagatta 74161 tcaatccgca gatgaaatga aaaaggatat gctagacgcg gggcaaaaag cagcacaaag 74221 aaaacagcct ataaaagcat caccgcagcc tgccacacga caaagacagc aaaaaccgcg 74281 ccaaggaaaa ataacgaaga cgcgatatac cccaaaacag aaaccggcta agtcgggggg 74341 gttatttgaa acaacgctta tcgtgatcag tgttttagcg ctttatttcg cctatattat 74401 ctttttctta atctgaatgg tgcaaactgc agagcctatg cttcttcttt gcttggaggg 74461 gttgaaagtg ttaggatatg aatatcttta aaatacctgc tcattgtgag gaggacattg 74521 tgaaaagtgt caaagatttt ttaaacaaac acaatcttac gttaaaaggg gcgacaatca 74581 ttgtaggcgt ttccggcggt ccggactcaa tggctcttct tcacgcgttg catacgttat 74641 gcggccgttc agcgaatgtt attgcagctc acgttgacca tcggttcaga ggtgcggaat 74701 ccgaggagga catgcgtttt gtccaagctt attgtaaagc tgaacagctc gtgtgcgaaa 74761 cggctcaaat caatgtaacc gcatatgcac aggaaaaagg actcaataag caggctgcag 74821 cacgcgattg ccgctaccag ttttttgagg aaatcatgtc gaagcaccaa gcggactatc 74881 tggctcttgc gcatcatggt gatgaccagg ttgaaacaat gcttatgaaa ctggctaagg 74941 gtacgcttgg aacgggactt gcgggaatgc agccggttag acgttttggg acagggcgga 75001 tcatcaggcc gttcttaacc attacaaagg aagagatcct tcactattgc catgaaaacg 75061 gcttgagcta ccggacggat gaaagcaacg ccaaagatga ctacacaaga aacagattca 75121 gaaaaacagt gctcccgttt ttgaagcagg aatctccgga tgtgcataaa aggtttcaga 75181 aagtgagtga agcactgacg gaagatgagc aattcttaca gtcattaacg aaagatgaaa 75241 tgaataaagt aatcacaagc cagtctaata catcagttga aatcaattcc tctcaattgc 75301 ttgccctccc gatgccttta caaagaagag gagttcaact aatattaaac tatctttatg 75361 aaaacgttcc atcatccttt tcagcccatc acattcagca gtttctcgat tgggcggaaa 75421 atggcggtcc ttcaggagta ctggactttc cgaaagggct gaaggtggtc aaatcatatc 75481 agacatgttt gtttacattt gaacaatggc agtgcaaaaa tgttcccttt gaataccaaa 75541 ttagcggagc tgctgatgaa acggcagtgc tccctaatgg atatctgata gaggcaaggc 75601 attatgcgga ctcgcctgaa gaacatggga atgctgtttt tatcacaagt gaaaaaaagg 75661 tgcgatttcc cttaacaatc cggacgagaa aagctggaga ccggatcaaa ctaaaaggga 75721 tgaacggctc aaaaaaggta aaggatatat ttattgataa gaaattgcct ctccaagaaa 75781 gagacaactg gccgattgtg acggacgcaa gcggtgaaat tatctggata cctggcttga 75841 aaaaatcaat ttttgaagat cttgtgattc caaacagcga ccgcattgta ttacaatata 75901 gacagcatga aaagtgtagg gggcaagcaa aatcatgatg aaacatgata tcgagaaagt 75961 actgatctca gaggaagaga tacaaaagaa agtaaaagag ttaggtgcag aattaacgag 76021 cgagtatcaa gatacatttc cgttggcaat cggtgtgtta aaaggagcac ttccttttat 76081 ggcggatctt atcaagcata ttgatacata tttggaaatg gatttcatgg atgtatcaag 76141 ctacggaaat tctacggttt cttctggaga agtaaaaatc attaaagatt tggatacatc 76201 tgtagagggc cgggacatct taattattga agatatcatc gacagtgggt taaccttaag 76261 ttatctcgta gagctcttcc gataccgtaa agcaaaatca attaagattg ttaccctttt 76321 ggataaaccg agcggaagaa aagcggacat caaagcagac tttgtcggtt ttgaagttcc 76381 tgacgcgttt gtagtgggtt acggacttga ttatgctgag cgctatcgca atctgcctta 76441 tatcggagtg ttaaaaccgg cagtttatga aagctgatcg gcagcctgct tccgagatgg 76501 ttattgtttg tattggaatg attttctatg gtactattga acatagttgt gcttactgtg 76561 ggaggaggta aggaatgaat cgggtcttcc gtaataccat tttttattta cttattttat 76621 tagtagtaat cggggttgtg agctacttcc agacctcaaa tccgaaaaca gaaaatatgt 76681 cgtacagtac gttcatcaaa aacctggatg acgggaaagt tgatagcgta tcggttcagc 76741 ctgtcagagg tgtttatgag gtaaaagggc agctgaaaaa ctacgacaaa gatcaatact 76801 ttttgactca tgttcctgaa ggaaagggag cagaccagat atttaacgct ttgaaaaaga 76861 cagacgtaaa ggttgagccc gcgcaagaaa caagcggatg ggtgacgttc ctgacgacca 76921 tcatcccatt tgtcattatc tttattctgt ttttcttcct gctcaatcag gctcaaggcg 76981 gcggcagccg tgtcatgaac tttggcaaga gtaaagcgaa gctgtataca gaggaaaaga 77041 aacgcgtcaa atttaaagac gttgcagggg ctgacgaaga aaagcaagaa cttgttgaag 77101 ttgttgagtt tctgaaagat ccccgcaagt ttgccgagct cggcgccaga ataccgaaag 77161 gcgtgctttt agtcggacct ccgggtaccg gtaaaacatt gcttgccaag gcttgtgcag 77221 gagaagccgg cgtacctttc ttcagcatca gcggatctga tttcgttgaa atgtttgtag 77281 gggtcggtgc ttcccgtgtg cgtgacttgt ttgaaaatgc gaaaaagaat gcgccttgtt 77341 tgatcttcat tgatgaaatt gacgcagtcg gacgccagcg tggcgctggt ctcggcggtg 77401 gacacgatga acgtgaacag acgctaaacc aattgcttgt tgaaatggac ggattcagcg 77461 ctaatgaagg aattatcatc attgctgcga cgaaccgtgc ggacatcttg gacccagcct 77521 tacttcgtcc gggacgtttt gaccgtcaaa tcacagtgga ccgcccagat gtcattggcc 77581 gtgaagctgt attgaaagtc catgcgagaa acaaaccgct ggatgaaacg gttaacctaa 77641 aatcaattgc catgagaaca ccaggcttct caggcgctga cttagaaaac ctcttgaatg 77701 aagctgcgct tgtagcggct cgtcaaaaca agaaaaaaat cgatgcgcgt gatattgacg 77761 aagcgacgga ccgtgtaatt gccggacccg ctaagaagag ccgcgttatc tccaagaaag 77821 aacgcaatat cgtggcttat cacgaaggcg gacacaccgt tatcggtctc gttttagatg 77881 aggcagatat ggttcataaa gtaacgattg ttcctcgggg ccaggctggc ggttatgctg 77941 ttatgctgcc aagagaagac cgttatttcc aaacaaagcc ggagctgctt gataaaattg 78001 tcggcctctt gggcggacgt gttgctgaag agattatctt cggtgaagtc agcacagggg 78061 cgcacaatga cttccagcgt gcgacgaata ttgcaagacg aatggttaca gaattcggta 78121 tgtcagaaaa actgggaccg ttgcaatttg gacagtctca gggcggtcag gtattcttag 78181 gccgtgattt caacaacgaa cagaactaca gtgatcaaat cgcttacgaa attgatcagg 78241 aaattcagcg catcatcaaa gaatgttatg agcgtgcgaa acaaatcctg actgaaaatc 78301 gtgacaagct tgaattgatt gcccaaacgc ttctgaaagt tgaaacgctt gacgctgaac 78361 aaatcaaaca ccttatcgat catggaacat tacctgagcg taatttctca gatgatgaaa 78421 agaacgatga tgtgaaagta aacattctga caaaaacaga agaaaagaaa gacgatacga 78481 aagagtaatt cgctttcttt ctaaaaaaac tgccggctga cgctggcagt ttttttatgt 78541 aaatgattgg ctcagctgcg gcttttacaa tcatccaatt ctggtatcga tttgtttaca 78601 aatgagccgc tgatcgtgta tggtattgta gaatgtttgt aaaaagtaaa gtagagaaac 78661 tattcaaaag tggtgataga ggttgttact ggttatcgat gtggggaaca ccaatactgt 78721 acttggtgta tatcatgatg gaaaattaga atatcactgg cgtatagaaa caagcaggca 78781 taaaacagaa gatgagtttg ggatgatttt gcgctcctta tttgatcact ccgggcttat 78841 gtttgaacag atagatggca ttattatttc gtcagtagtg ccgccaatca tgtttgcgtt 78901 agaaagaatg tgcacaaaat actttcatat cgagcctcaa attgttggtc caggtatgaa 78961 aaccggttta aatataaaat atgacaatcc gaaagaagta ggggcagaca gaatcgtaaa 79021 tgctgtcgct gcgatacact tgtacggcaa tccattaatt gttgtcgatt tcggaaccgc 79081 cacaacgtac tgctatattg atgaaaacaa acaatacatg ggcggggcga ttgcccctgg 79141 gattacaatt tcgacagagg cgctttactc gcgtgcagca aagcttcctc gtatcgaaat 79201 cacccggccc gacaatatta tcggaaaaaa cactgttagc gcgatgcaat ctggaatttt 79261 atttggctat gtcggccaag tggaaggaat cgttaagcga atgaaatggc aggcaaaaca 79321 ggaaccaaag gtcattgcga caggaggcct ggcgccgctc attgcgaacg aatcagattg 79381 tatagacatc gttgatccat tcttaaccct aaaagggctg gaattgattt atgaaagaaa 79441 ccgcgtagga agtgtatagg aggtttagta atggattatt tagtaaaagc acttgcgtat 79501 gacggaaaag ttcgggctta tgcagcgaga acgactgata tggtaaatga ggggcagaga 79561 cgccatggta cgtggccgac agcatccgct gcactaggcc gtacaatgac agcttcactt 79621 atgctcggcg ctatgctgaa gggcgatgat aagctgaccg tgaaaatcga gggcggaggt 79681 ccgatcggag ctattgtagc tgatgccaat gccaaaggag aagtcagagc ctatgtctct 79741 aacccgcaag ttcattttga tttaaatgaa caaggtaagc ttgatgtcag acgtgcggtt 79801 ggaacaaacg gaacgttaag tgtcgtaaaa gatttaggtt tgcgcgagtt cttcacagga 79861 caagtagaaa tcgtttcagg agaattagga gatgatttta cttactatct tgtgtcatct 79921 gagcaggttc cttcatcagt gggcgtaggt gtgctcgtaa atcctgacaa taccattctt 79981 gcggcagggg gctttattat tcagctgatg ccgggaacag atgatgaaac aatcacaaaa 80041 attgaacagc gtctatctca agtagagccg atttctaagc tcatccaaaa agggctgaca 80101 ccagaagaaa ttttagaaga agtcctaggc gagaaacctg agattttgga aacgatgcct 80161 gtcagattcc attgcccttg ttcaaaagaa cggttcgaaa cagccatttt aggactaggc 80221 aaaaaagaaa ttcaagatat gatagaagaa gatggacaag ccgaagcagt atgccatttt 80281 tgtaatgaaa agtacttatt tacaaaagaa gagctggaag ggcttcgtga ccaaactacc 80341 cgctaagctc tttagcgggt ttttaatttg agaaaagggg ctgaaagcag gtttgaaatc 80401 aagaacaatc tggaccatta ttttaggggc gctgttggtt tgctgtattg ctgttgcata 80461 tacgctgacg aaatcccaag ccggcgcatc gtcatccggt gagtctattg cgactatcgg 80521 aggcaagagt gtgacaagag aagaatggct gaaagaaatg gaagatcagt atggtaagtc 80581 aacgcttgaa gatatgatca atgtccgagt tgttgagcag ctggctaaaa agaacaaact 80641 taaaatatcc aaaagcgaag ttgatcgtga gtttttgctg attaaagcgg tcaataattc 80701 cttttacgaa gatgaacata cgacggagaa agagtggaaa gaccaaattc gttataatat 80761 cctccttgag gatttgttaa caagggatat cgatatctca aacaaagaat tggaatcatt 80821 ctataataaa aataaggaac tatatcagtt tgatgattcg tatcgaattc ggcacattgt 80881 tgtaaaagat gaagaagaag caagagaagt cctgaaagaa ctgaaaggcg gatcaagctt 80941 tgaagctgtc gctgccgaaa gatctacaga cagatataca tcaccatacg gcggagattt 81001 aggttttgtc acagaggcat cagacaacat tccatcagca tacattgaag aggcgaaaac 81061 actcaaagag gatgaatggt ctcaggaacc aataaaggtc agcaacggat atgccattat 81121 ccagctgaaa gaaaaactaa aggcaagaac gttctcattt gatgaagtaa aggaccagat 81181 cagacggcaa atcgcaatgg atcagctagg cgataaagcg acagttaaga cactttggaa 81241 agaagccgat gtatcttggt tttatgggga aaaaagtact aagtgattga caaaaaattt 81301 tgaaattgat agattatata cataatacca atacaaatag tcggaaattg aggtgtcgag 81361 aatggtacgt gtagcaaact ccattactga attaattggg aatacgccaa tcgttaaatt 81421 aaatcgcctt gcagatgaaa acagtgcgga tgtatatcta aaacttgaat acatgaaccc 81481 tggaagcagt gtaaaagacc gtatcggttt agctatgatt gaagcggctg aaaaagaagg 81541 aaaattaaaa gccggtaata caatcattga accgacaagc ggaaatactg gaatcgggct 81601 tgcaatggtt gctgctgcta aaggattaaa agccattttg gttatgcctg atacaatgag 81661 catggagcgc cgcaaccttc ttcgcgcata tggtgctgag cttgtgctga ctcctggtgc 81721 ggaaggcatg aaaggtgcta ttaagaaagc tgaagagctt gctgaaaagc acggatactt 81781 tgtgccgcag cagtttaaca acccttctaa ccccgaaatt caccgccaaa caacgggtaa 81841 agaaatcgtt gagcaattcg gtgatgatca gcttgacgca tttgtagccg gaatcggaac 81901 gggcggaacg attacgggag cgggcgaagt gctgaaggaa gcataccctt ccatcaagat 81961 ttatgctgtt gaaccgtcag attccccagt gctttcagga ggaaaaccag gcccccacaa 82021 aattcaggga atcggagcag gattcgtgcc ggacatctta aacactgaag tatatgatga 82081 aatcttccct gtgaagaatg aagaagcatt cgaatatgcc cgcagagctg cacgtgaaga 82141 aggaattctc ggaggcatct catcaggtgc ggcaatttat gctgctcttc aagtagcaaa 82201 aaaactcgga aaaggcaaaa aagtattggc catcattcca agtaacggcg aacgttatct 82261 aagcacgccg ctgtaccaat tcgattaaaa aaagccaaaa ctcccggttc gccgggagtt 82321 tttttatatt tcgtgcatca aatatgccat gtctgcgacg aatgttattc ttggaagaga 82381 aattcacttt tttcactaac aacattgctt tacaattaaa aacaagtaaa aaagaaaata 82441 gaggaatgat acaaatggca caacgcagac cggcaggcaa aaaaatacct tttcaaaaag 82501 actcattctt acaacaattt gagaaacttg cgcaatcccg gaaacatcat gtacttctcg 82561 aaagtgcaag aggcggcaga tatagtatag ccggtcttga tccaattgcg actgtgaaag 82621 gaaaagacgg aataactaca attaagcatg gtgatgagat gctgtttaaa gaaggtgatc 82681 cattacgggc cttccacagc tggtttaaaa cactggaaac agaaacgaat catgagttcc 82741 ctgactttca aggcggggca atcgggtttc tcagctatga ttacgcacgg tacattgaaa 82801 attttaaaat gctctcatta gatgatttag aaacaccaga tatttatttt cttgtttttg 82861 atgatatagc agtttatgac catcaagaag agtctctatg gctgattact catgttaatg 82921 gttctgatca ggaaacagcg gatgtgaagc tatctgagtt agagcagatg tggttgactg 82981 agcttcccgc tgtcacttcg cgagagatga agcctgaaac agctggttct ttcgcggcgc 83041 catttaccga ggatgggttc tcacaagctg tagagaaaat caaacaatac attgccagcg 83101 gagatgtgtt tcaagtcaat ctatcaataa ggcagtcaca gtcactgtct gtccacccat 83161 atcaaattta caaaaccttg agagaagtaa atccttctcc ttatatggcg tatttagaaa 83221 cacctgattt ccaaatcatt tgcggatcgc ctgaactgct tgtcagcaaa aagggcaagc 83281 tattagagac gagaccgatt gcgggcaccc gttccagagg gaaaacaaat gaagaagacg 83341 aggcgcttgc aaacgaattg atacacaatg aaaaagaacg cgcggaacat gtcatgctgg 83401 ttgatcttga gcgaaatgat ctgggaagag tatcacgtta cgggtctgtg cgcgtaaatg 83461 aattcatggc aattgaaaaa tactcgcatg tgatgcacat tgtgtctaat gtccaaggtg 83521 aactgcagga tgggtatgat gctgtagata ttattcatgc tgtgtttccc ggaggaacca 83581 ttactggtgc accgaaagta agaacgatgg aaattataga agaacttgag ccgacacgcc 83641 gagggcttta tactggatct ataggatggt ttggatataa tcacgatctg cagtttaata 83701 tcgtcattcg aaccatttat gcaaccggag ggcaggcatt tatgcagtcc ggtgcaggag 83761 ttgtgattga ttctgttccg aagcacgaat acaaggaatc attcaaaaaa gcttttgcga 83821 tgcaaagagc attagagctg agcgaagaag agacaaaaat tagatgaggt gagcggagaa 83881 atgattttaa tgattgataa ctacgattca ttcacgtaca acttggtaca gtatttgggc 83941 gagcttgggg aagagctggt tgtgaaacgc aatgacagca tcacaatcga tgaaattgaa 84001 gaactgtctc cggactttct gatgatatct cccggaccgt gcagccctga tgaggcggga 84061 atcagcctcg aagcaattaa acatttcgca gggaaaattc ctattttcgg tgtatgtctc 84121 ggacatcagt ccatcgcaca agtgttcggt ggtgatgttg ttagggcaga acggcttatg 84181 cacgggaaaa cctcggatat cgagcatgac ggcaaaacca tttttgaagg gttgaaaaat 84241 ccccttgttg cgacgcgata ccactcgctg atcgtaaaac ctgagacgct gccaagctgt 84301 tttacagtaa cagcacaaac gaaagaagga gaaatcatgg ctattcgcca caatgacctc 84361 ccgatagagg gtgtgcaatt tcacccagag tctattatga cctcctttgg gaaagaaatg 84421 ctcagaaatt ttattgagac atatcgcaag gaagttattg cgtgatgata tatgtgaacg 84481 gccggtatat ggaggagaaa gatgcagttc tttctccttt tgaccatggg tttttatatg 84541 ggatcggtgt tttcgaaacc ttcaggctct acgaaggctg cccgtttttg cttgattggc 84601 atatagagag gcttgaacgc gcgcttaagg atctgcaaat cgaatatact gtttcaaagc 84661 atgagatcct tgagatgctg gacaagctgc ttaagctaaa tgatatcaag gatggcaatg 84721 cccgcgtcag actgaacata tcagcgggaa tcagcgataa aggctttgtc gcccagacgt 84781 acgataagcc caccgtttta tgctttgtga atcagctgaa accagaaagt cttcctttgc 84841 aaaaagaagg aaaggtttta tcgatacgga gaaacactcc agagggatcg ttccggttaa 84901 aatctcatca ttatctaaat aatatgtatg cgaaacggga aattggaaat gatccgcgtg 84961 tcgagggaat tttcttaacg gaggatggag ctgttgcaga gggtatcata tctaatgtct 85021 tctggagaaa aggtcgctgt atctatacgc catcgcttga taccggtatt ctggacggcg 85081 tcacgagacg ttttatcata gaaaatgcaa aggatatcgg cctggagctc aaaacgggcc 85141 gatatgagct agaagctctc ttgacagctg acgaagcgtg gatgacgaac tcggttcttg 85201 aaatcatccc gtttactaaa atagaagaag taaactatgg aagccaaagc ggagaagcaa 85261 cctccgctct tcaattgtta tacaaaaaag aaataaagaa catgattcat gaaaagggag 85321 gaagagcatg gcgcagcaca caatagatca aacacaagta atccacacta agcccagcgc 85381 tttatcatat aaagagaaga cgctggtgat gggaatttta aacgtaacgc ctgactcttt 85441 ctcggacggc ggaaaatatg acagcttgga caaggcgctg ctgcacgcga aagagatgat 85501 cgatgatggt gcccatatca ttgatattgg aggggaatcg acaaggcctg gcgctgagtg 85561 cgtatctgag gatgaggaga tgtccagagt cattccggtg attgagcgga ttacgaaaga 85621 gcttggtgtt cctatttctg tagacacgta caaggcttct gtcgcagatg aagcagtgaa 85681 agccggtgca tccattatca atgatatttg gggagccaaa catgatccga agatggcttc 85741 cgttgcagct gaacataatg ttccaattgt actcatgcat aaccgccctg aaagaaacta 85801 caatgactta ttgccggata tgctgtcgga cttaatggag agtgtaaaaa ttgctgttga 85861 ggccggagta gacgagaaga acattattct tgatcctggt atcggtttcg cgaaaaccta 85921 tcacgataac ttggcagtga tgaacaaact agagattttc agcggattgg gatatccggt 85981 tcttctggca acctcccgaa aaagattcat cggacgtgtt ctggatcttc cgcctgagga 86041 gcgggctgag ggcacaggcg cgactgtgtg tctcggcatt caaaaaggct gtgacattgt 86101 cagggtccat gatgtaaagc aaattgccag aatggcgaaa atgatggacg cgatgctgaa 86161 taagggaggg gtgcaccatg gataaagttt atgtagaagg tatggagttt tacggatatc 86221 acggtgtgtt cacagaagaa aacaaacttg gccagcggtt taaagtcgat ttaaccgctg 86281 agctggattt aagcaaagct ggacagacag acgaccttga gcaaacgatc aactatgctg 86341 agctctatca cgtatgtaaa gatatcgtgg aaggggagcc tgtgaaattg gtggaaacgc 86401 tggcggaacg tattgctggc actgttctcg gaaaatttca gcctgttcag caatgtacgg 86461 tgaaagtgat taagccagac ccgccaattc ccggacacta taaatcagta gcaattgaaa 86521 ttacgagaaa aaagtcatga acaacatagc ttatattgca cttggatcta atattggaga 86581 tagagaaacg tatttaaggc aagcagtggc tttactgcat cagcatgctg cggtgacagt 86641 cactaaagtg tcgtctattt acgaaactga cccggtcgga tacgaagatc aagctcaatt 86701 tttgaatatg gctgttgaaa tcaagacatc attgaaccct tttgaactcc ttgaactgac 86761 gcagcagata gaaaatgaat taggcagaac aagggaagta agatgggggc cgcggacggc 86821 agaccttgac attttgttat ttaatcgtga aaatattgaa acagagcaac taattgttcc 86881 gcatccgaga atgtatgagc gtttgtttgt ccttgcgccg cttgcggaaa tttgccagca 86941 ggttgaaaaa gaggctacaa gcgccgaaac agaccaagaa ggtgtaagag tatggaagca 87001 gaaatctggg gtagacgaat tcgtgcattc agaaagctga aaggttatac tcaagaagga 87061 tttgcaaaag cattaggtat atcagtttct attctcggcg aaattgaacg cggaaaccga 87121 ttgccgtctg ctgccatcat tcaagatgca gcagatgttt taaatataag tgcggacgaa 87181 ttggcgccgc cagaaaaata gaacaaatga aaggaggaga aaaattgttc aaaatcggag 87241 atattcaatt gaaaaaccgg gttgtgctcg cacctatggc tggtgtctgc aactctgcgt 87301 tcagattgac tgtaaaggaa ttcggagccg gattggtatg cgctgaaatg gtcagtgaca 87361 aagcgatcct ttacaacaat gcaagaacaa tgggtatgct ttatattgat gaacgtgaga 87421 aaccactgag ccttcaaatt ttcggaggaa aaaaggaaac ccttgtggaa gcggcgaagt 87481 ttgtagacca aaacacaact gctgatatca ttgatattaa catgggatgt cccgtgccga 87541 agattacaaa atgcgatgcg ggagccaaat ggcttctcga tcctgataag atttacgaaa 87601 tggtttctgc agtagtggat gctgttaata agccagttac agtgaaaatg agaatgggct 87661 gggatgaaga ccacattttc gcagtgaaaa atgcacaggc tgtagaacgt gcgggcggta 87721 aagcagtggc gcttcacggc cgtacgagag tgcagatgta cgaaggaacg gcaaactggg 87781 atatcatcaa agaagtaaaa caatcagtat cgattccggt tatcggaaac ggcgatgtta 87841 agacaccgca ggatgctaag cgtatgctcg atgagacagg agtagacggg gtcatgatcg 87901 gacgcgctgc attgggtaac ccgtggatga tttaccgtac ggttcagtat cttgaaacag 87961 gtaaattaaa agaagagccg caagtacgcg aaaaaatggc cgtatgcaaa ctgcatcttg 88021 accgcctgat tgacttaaaa ggtgaaaacg tagcggtaag agaaatgaga aagcacgctg 88081 catggtatct gaaaggcgtg aaaggcaatg cgaacgttcg taatgaaatc aatcattgcg 88141 agacgagaga agagtttgta cagcttttag atgcatttac ggttgaagtt gaggcaaaag 88201 agcttcaaaa tgcaaaagta ggataatact cacctctatt tgctgctcac tgctagtttt 88261 acgctggcag tttttctgct tttttcatga aacaatatct gtaatggagt gataacaatg 88321 agtcaagaag agcataacca tgaagaattg aatgatcagc tgcaagtcag acgcgataaa 88381 atgaatcagc tgagagataa cggcatcgat ccattcggcg cacgttttga aagaactcat 88441 cagtctcaag aagttatttc ggcatatcaa gatctaacca aagaagagtt agaagaaaaa 88501 gcgattgaag ttacaatcgc aggccgcatg atgacaaaac gcggcaaagg aaaagccggc 88561 tttgcccatc ttcaggattt agaaggccaa atccaaatct acgtaagaaa agacagtgtc 88621 ggtgacgacc aatatgaaat cttcaagtct tctgacctcg gtgatcttat cggcgtaacc 88681 ggaaaagtct tcaaaacaaa tgtaggcgaa ttgtctgtta aagcaacttc ctttgaattg 88741 ctgacaaaag cgcttcgtcc gcttcctgac aaataccatg gtttaaaaga cgttgagcag 88801 cgctaccgtc agcgctatct ggatcttatc gtaaacccag acagcaaaca tacgttcatt 88861 acacgaagca agatcattca agctatgaga aggtaccttg atgatcatgg atacttagaa 88921 gtagaaacac ctacaatgca cagcattcct gggggagctt ctgcacgtcc gtttatcact 88981 caccacaacg cgttagacat tccactctat atgcgtattg ctatcgaact gcacctaaaa 89041 cgtctaattg tcggcggttt agaaaaagta tatgaaatcg gccgtgtttt ccgtaacgaa 89101 ggtgtctcta cacgccataa ccctgaattt acaatgattg agttatatga agcatatgcg 89161 gactataaag atatcatgag cttaactgaa aaccttgtcg ctcatatcgc ccaagaagtg 89221 cttggcacaa ctacgattca atacggggaa gagcaaatcg accttaaacc ggagtggaaa 89281 agaatccata tggttgacgc agtcaaagaa gcgaccggcg ttgatttctg ggaagaggtt 89341 actgttgagc aggcgcgtga atatgcaaaa gaacatgaag tagaaattaa agactctatg 89401 acagtaggcc atatcatcaa cgaattcttc gaacaaaaaa ttgaagaaac gcttattcag 89461 ccaacgttta tttacgggca tcctgtagaa atttctcctc ttgctaagaa aaaccctgag 89521 gacccgcgtt ttacagaccg ttttgagctg tttatcgttg gccgtgaaca tgccaacgcg 89581 tttacagagc tgaatgatcc tattgatcaa agagaacgct ttgaagcgca attaaaagag 89641 cgtgaagccg gtaatgatga agctcattta atggatgaag actttgttga agctctggaa 89701 tacggtatgc cgccaacagg aggtttaggc atcggtatcg accgtctggt tatgctgctg 89761 acgaatgccc cttctattcg cgatgtgctg ttattcccgc aaatgagaca acgctaataa 89821 aaaagagcgg tatcctccat agggaaagga tgccgctctt tttaaatccc ttagtatttc 89881 ttcaaaaaaa ctattgcact attatttact aggtggtata ttattattcg ttgccgctaa 89941 acaaggcgat aacgaaaaaa agaacttcaa aaaaagttat tgacttcact gagtcaacga 90001 gttataataa taaagtcgct tgaacgaagt gaacaaaatg atctttgaaa actaaacaag 90061 acaaaacgta cctgttaatt cagtttttaa aaatcgcaca gcgatgtgcg tagtcagtca 90121 aactacttta tcggagagtt tgatcctggc tcaggacgaa cgctggcggc gtgcctaata 90181 catgcaagtc gagcggacag atgggagctt gctccctgat gttagcggcg gacgggtgag 90241 taacacgtgg gtaacctgcc tgtaagactg ggataactcc gggaaaccgg ggctaatacc 90301 ggatggttgt ttgaaccgca tggttcaaac ataaaaggtg gcttcggcta ccacttgcag 90361 atggacccgc ggcgcattag ctagttggtg aggtaatggc tcaccaaggc aacgatgcgt 90421 agccgacctg agagggtgat cggccacact gggactgaga cacggcccag actcctacgg 90481 gaggcagcag tagggaatct tccgcaatgg acgaaagtct gacggagcaa cgccgcgtga 90541 gtgatgaagg ttttcggatc gtaaagctct gttgttaggg aagaacaagt gccgttcgaa 90601 tagggcggta ccttgacggt acctaaccag aaagccacgg ctaactacgt gccagcagcc 90661 gcggtaatac gtaggtggca agcgttgtcc ggaattattg ggcgtaaagg gctcgcaggc 90721 ggtttcttaa gtctgatgtg aaagcccccg gctcaaccgg ggagggtcat tggaaactgg 90781 ggaacttgag tgcagaagag gagagtggaa ttccacgtgt agcggtgaaa tgcgtagaga 90841 tgtggaggaa caccagtggc gaaggcgact ctctggtctg taactgacgc tgaggagcga 90901 aagcgtgggg agcgaacagg attagatacc ctggtagtcc acgccgtaaa cgatgagtgc 90961 taagtgttag ggggtttccg ccccttagtg ctgcagctaa cgcattaagc actccgcctg 91021 gggagtacgg tcgcaagact gaaactcaaa ggaattgacg ggggcccgca caagcggtgg 91081 agcatgtggt ttaattcgaa gcaacgcgaa gaaccttacc aggtcttgac atcctctgac 91141 aatcctagag ataggacgtc cccttcgggg gcagagtgac aggtggtgca tggttgtcgt 91201 cagctcgtgt cgtgagatgt tgggttaagt cccgcaacga gcgcaaccct tgatcttagt 91261 tgccagcatt cagttgggca ctctaaggtg actgccggtg acaaaccgga ggaaggtggg 91321 gatgacgtca aatcatcatg ccccttatga cctgggctac acacgtgcta caatggacag 91381 aacaaagggc agcgaaaccg cgaggttaag ccaatcccac aaatctgttc tcagttcgga 91441 tcgcagtctg caactcgact gcgtgaagct ggaatcgcta gtaatcgcgg atcagcatgc 91501 cgcggtgaat acgttcccgg gccttgtaca caccgcccgt cacaccacga gagtttgtaa 91561 cacccgaagt cggtgaggta accttttagg agccagccgc cgaaggtggg acagatgatt 91621 ggggtgaagt cgtaacaagg tagccgtatc ggaaggtgcg gctggatcac ctcctttcta 91681 aggatatttt acggaatata agaccttggg tcttataaac agaacgttcc ctgtcttgtt 91741 tagttttgaa ggatcattcc ttcgaaacgt gttctttgaa aactagataa cagtagacat 91801 cacattcaag taatacaaga tatcacatag tgattctttt taacggttaa gttagaaagg 91861 gcgcacggtg gatgccttgg cactaggagc cgatgaagga cgggacgaac accgatatgc 91921 ttcggggagc tgtaagcaag ctttgatccg gagatttccg aatggggaaa cccaccactc 91981 gtaatggagt ggtatccata tctgaattca taggatatga gaaggcagac ccggggaact 92041 gaaacatcta agtacccgga ggaagagaaa gcaaatgcga ttccctgagt agcggcgagc 92101 gaaacgggat tagcccaaac caagaggctt gcctcttggg gttgtaggac actctgtacg 92161 gagttacaaa ggaacgaggt agatgaagag gtctggaaag gcccgccata ggaggtaaca 92221 gccctgtagt caaaacttcg ttctctcctg agtggatcct gagtacggcg gaacacgtga 92281 aattccgtcg gaatccggga ggaccatctc ccaaggctaa atactcccta gtgaccgata 92341 gtgaaccagt accgtgaggg aaaggtgaaa agcaccccgg aaggggagtg aaagagatcc 92401 tgaaaccgtg tgcctacaag tagtcagagc ccgttaacgg gtgatggcgt gccttttgta 92461 gaatgaaccg gcgagttacg atcccgtgca aggttaagca gaagatgcgg agccgcagcg 92521 aaagcgagtc tgaatagggc gcatgagtac gtggtcgtag acccgaaacc aggtgatcta 92581 cccatgtcca gggtgaagtt caggtaacac tgaatggagg cccgaaccca cgcacgttga 92641 aaagtgcggg gatgaggtgt gggtaggggt gaaatgccaa tcgaacctgg agatagctgg 92701 ttctctccga aatagcttta gggctagcct caaggtaaga gtcttggagg tagagcactg 92761 attggactag gggcccctac cgggttaccg aattcagtca aactccgaat gccaatgact 92821 tatccttggg agtcagactg cgagtgataa gatccgtagt cgaaagggaa acagcccaga 92881 ccgccagcta aggtcccaaa gtatacgtta agtggaaaag gatgtggagt tgcttagaca 92941 accaggatgt tggcttagaa gcagccacca tttaaagagt gcgtaatagc tcactggtcg 93001 agtgactctg cgccgaaaat gtaccggggc taaacgtatc accgaagctg cggactgttc 93061 ttcgaacagt ggtaggagag cgttctaagg gctgtgaagc cagaccggaa ggactggtgg 93121 agcgcttaga agtgagaatg ccggtatgag tagcgaaaga ggggtgagaa tcccctccac 93181 cgaatgccta aggtttcctg aggaaggctc gtccgctcag ggttagtcgg gacctaagcc 93241 gaggccgaaa ggcgtaggcg atggacaaca ggttgatatt cctgtaccac ctcctcacca 93301 tttgagcaat ggggggacgc aggaggatag ggtaagcgcg gtattggata tccgcgtcca 93361 agcagttagg ctgggaaata ggcaaatccg tttcccataa ggctgagctg tgatggcgag 93421 cgaaatatag tagcgaagtt cctgattcca cactgccaag aaaagcctct agcgaggtga 93481 gaggtgcccg taccgcaaac cgacacaggt aggcgaggag agaatcctaa ggtgatcgag 93541 agaactctcg ttaaggaact cggcaaaatg accccgtaac ttcgggagaa ggggtgctct 93601 gttagggtgc aagcccgaga gagccgcagt gaataggccc aggcgactgt ttagcaaaaa 93661 cacaggtctc tgcgaagccg taaggcgaag tataggggct gacgcctgcc cggtgctgga 93721 aggttaagag gagcgcttag cgtaagcgaa ggtgcgaatt gaagccccag taaacggcgg 93781 ccgtaactat aacggtccta aggtagcgaa attccttgtc gggtaagttc cgacccgcac 93841 gaaaggcgca acgatctggg cactgtctca acgagagact cggtgaaatt atagtacctg 93901 tgaagatgca ggttacccgc gacaggacgg aaagaccccg tggagcttta ctgcagcctg 93961 atattgaatg ttggtacagc ttgtacagga taggtaggag ccttggaaac cggagcgcca 94021 gcttcggtgg aggcatcggt gggatactac cctggctgta ttgaccttct aacccgccgc 94081 ccttatcggg cggggagaca gtgtcaggtg ggcagtttga ctggggcggt cgcctcctaa 94141 aaggtaacgg aggcgcccaa aggttccctc agaatggttg gaaatcattc gcagagtgta 94201 aaggcacaag ggagcttgac tgcgagacct acaagtcgag cagggacgaa agtcgggctt 94261 agtgatccgg tggttccgca tggaagggcc atcgctcaac ggataaaagc taccccgggg 94321 ataacaggct tatctccccc aagagtccac atcgacgggg aggtttggca cctcgatgtc 94381 ggctcatcgc atcctggggc tgtagtcggt cccaagggtt gggctgttcg cccattaaag 94441 cggtacgcga gctgggttca gaacgtcgtg agacagttcg gtccctatcc gtcgcgggcg 94501 caggaaattt gagaggagct gtccttagta cgagaggacc gggatggacg caccgctggt 94561 gtaccagttg ttctgccaag ggcatcgctg ggtagctatg tgcggacggg ataagtgctg 94621 aaagcatcta agcatgaagc ccccctcaag atgagatttc ccattccgca aggaagtaag 94681 atccctgaaa gatgatcagg ttgataggtc tgaggtggaa gtgtggcgac acatggagct 94741 gacagatact aatcgatcga ggacttaacc atatttttga atgatgtcac atctgttatc 94801 tagttttgag agaacactct caatttgttt ggtggcgata gcgaagaggt cacacccgtt 94861 cccataccga acacggaagt taagctcttc agcgccgatg gtagtcgggg gtttccccct 94921 gtgagagtag gacgccgcca agcaattgca cgttagtgca attatggagg attagctcag 94981 ctgggagagc atctgcctta caagcagagg gtcggcggtt cgagcccgtc atcctccacc 95041 attatgccgg tgtagctcaa ttggtagagc aactgacttg taatcagtag gttgggggtt 95101 caagtcctct tgccggcacc acttttatat gatataatac tcaagtctct tgtagaagag 95161 ccattagctc agttggtaga gcatctgact tttaatcaga gggtcgaagg ttcgagtcct 95221 tcatggctca ccattttacg cgggtgtggc ggaattggca gacgcgctag acttaggatc 95281 tagtgtcttt atgacgtggg ggttcaagtc ccttcacccg cattatatag gataacagtt 95341 agaaaaactg gacatcctgt ctgcggaagt agttcagtgg tagaacacca ccttgccaag 95401 gtgggggtcg cgggttcgaa tcccgtcttc cgctccaact ataccatcca cgccggggtg 95461 gtggaattgg cagacacaca ggacttaaaa tcctgcggta ggtgactacc gtgccggttc 95521 aagtccggcc ctcggcatta tgttttgcgc ccgtagctca attggataga gcgtttgact 95581 acggatcaaa aggttagggg ttcgactcct ctcgggcgcg ccatatcttt taatagaata 95641 gataggaaat cgggaagtag ctcagcttgg tagagcacat ggtttgggac catggggtcg 95701 caggttcgaa tcctgtcttc ccgaccattt ttttatgggg ccttagctca gctgggagag 95761 cgcctgcttt gcacgcagga ggtcagcggt tcgatcccgc taggctccac caaaagtttt 95821 taaaaaagtt gttgactttg aagaagtgac gttgtatact aataaagttg ctttaacaaa 95881 gcggacaaac aaaatgatct ttgaaaacta aacaagacaa aacgtacctg ttaattcagt 95941 ttttaaaaat cgcacagcga tgtgcgtagt cagtcaaact actttatcgg agagtttgat 96001 cctggctcag gacgaacgct ggcggcgtgc ctaatacatg caagtcgagc ggacagatgg 96061 gagcttgctc cctgatgtta gcggcggacg ggtgagtaac acgtgggtaa cctgcctgta 96121 agactgggat aactccggga aaccggggct aataccggat ggttgtttga accgcatggt 96181 tcaaacataa aaggtggctt cggctaccac ttacagatgg acccgcggcg cattagctag 96241 ttggtgaggt aacggctcac caaggcaacg atgcgtagcc gacctgagag ggtgatcggc 96301 cacactggga ctgagacacg gcccagactc ctacgggagg cagcagtagg gaatcttccg 96361 caatggacga aagtctgacg gagcaacgcc gcgtgagtga tgaaggtttt cggatcgtaa 96421 agctctgttg ttagggaaga acaagtaccg ttcgaatagg gcggtacctt gacggtacct 96481 aaccagaaag ccacggctaa ctacgtgcca gcagccgcgg taatacgtag gtggcaagcg 96541 ttgtccggaa ttattgggcg taaagggctc gcaggcggtt tcttaagtct gatgtgaaag 96601 cccccggctc aaccggggag ggtcattgga aactggggaa cttgagtgca gaagaggaga 96661 gtggaattcc acgtgtagcg gtgaaatgcg tagagatgtg gaggaacacc agtggcgaag 96721 gcgactctct ggtctgtaac tgacgctgag gagcgaaagc gtggggagcg aacaggatta 96781 gataccctgg tagtccacgc cgtaaacgat gagtgctaag tgttaggggg tttccgcccc 96841 ttagtgctgc agctaacgca ttaagcactc cgcctgggga gtacggtcgc aagactgaaa 96901 ctcaaaggaa ttgacggggg cccgcacaag cggtggagca tgtggtttaa ttcgaagcaa 96961 cgcgaagaac cttaccaggt cttgacatcc tctgacaatc ctagagatag gacgtcccct 97021 tcgggggcag agtgacaggt ggtgcatggt tgtcgtcagc tcgtgtcgtg agatgttggg 97081 ttaagtcccg caacgagcgc aacccttgat cttagttgcc agcattcagt tgggcactct 97141 aaggtgactg ccggtgacaa accggaggaa ggtggggatg acgtcaaatc atcatgcccc 97201 ttatgacctg ggctacacac gtgctacaat ggacagaaca aagggcagcg aaaccgcgag 97261 gttaagccaa tcccacaaat ctgttctcag ttcggatcgc agtctgcaac tcgactgcgt 97321 gaagctggaa tcgctagtaa tcgcggatca gcatgccgcg gtgaatacgt tcccgggcct 97381 tgtacacacc gcccgtcaca ccacgagagt ttgtaacacc cgaagtcggt gaggtaacct 97441 tttaggagcc agccgccgaa ggtgggacag atgattgggg tgaagtcgta acaaggtagc 97501 cgtatcggaa ggtgcggctg gatcacctcc tttctaagga tattttacgg aatataagac 97561 cttgggtctt ataaacagaa cgttccctgt cttgtttagt tttgaaggat cattccttcg 97621 aaacgtgttc tttgaaaact agataacagt agacatcaca ttcaagtaat acaagatatc 97681 acatagtgat tctttttaac ggttaagtta gaaagggcgc acggtggatg ccttggcact 97741 aggagccgat gaaggacggg acgaacaccg atatgcttcg gggagctgta agcaagcttt 97801 gatccggaga tttccgaatg gggaaaccca ccactcgtaa tggagtggta tccatatctg 97861 aattcatagg atatgagaag gcagacccgg ggaactgaaa catctaagta cccggaggaa 97921 gagaaagcaa atgcgattcc ctgagtagcg gcgagcgaaa cgggatcagc ccaaaccaag 97981 aggcttgcct cttggggttg taggacactc tgtacggagt tacaaaggaa cgaggtagat 98041 gaagaggtct ggaaaggccc gccataggag gtaacagccc tgtagtcaaa acttcgttct 98101 ctcctgagtg gatcctgagt acggcggaac acgtgaaatt ccgtcggaat ccgggaggac 98161 catctcccaa ggctaaatac tccctagtga ccgatagtga accagtaccg tgagggaaag 98221 gtgaaaagca ccccggaagg ggagtgaaag agatcctgaa accgtgtgcc tacaagtagt 98281 cagagcccgt taacgggtga tggcgtgcct tttgtagaat gaaccggcga gttacgatcc 98341 cgtgcaaggt taagcagaag atgcggagcc gcagcgaaag cgagtctgaa tagggcgcat 98401 gagtacgtgg tcgtagaccc gaaaccaggt gatctaccca tgtccagggt gaagttcagg 98461 taacactgaa tggaggcccg aacccacgca cgttgaaaag tgcggggatg aggtgtgggt 98521 aggggtgaaa tgccaatcga acctggagat agctggttct ctccgaaata gctttagggc 98581 tagcctcaag gtaagagtct tggaggtaga gcactgattg gactaggggc ccctaccggg 98641 ttaccgaatt cagtcaaact ccgaatgcca atgacttatc cttgggagtc agactgcgag 98701 tgataagatc cgtagtcgaa agggaaacag cccagaccgc cagctaaggt cccaaagtat 98761 acgttaagtg gaaaaggatg tggagttgct tagacaacca ggatgttggc ttagaagcag 98821 ccaccattta aagagtgcgt aatagctcac tggtcgagtg actctgcgcc gaaaatgtac 98881 cggggctaaa cgtatcaccg aagctgcgga ctgttcttcg aacagtggta ggagagcgtt 98941 ctaagggctg tgaagccaga ccggaaggac tggtggagcg cttagaagtg agaatgccgg 99001 tatgagtagc gaaagagggg tgagaatccc ctccaccgaa tgcctaaggt ttcctgagga 99061 aggctcgtcc gctcagggtt agtcgggacc taagccgagg ccgaaaggcg taggcgatgg 99121 acaacaggtt gatattcctg taccacctcc tcaccatttg agcaatgggg ggacgcagga 99181 ggatagggta agcgcggtat tggatatccg cgtccaagca gttaggctgg gaaataggca 99241 aatccgtttc ccataaggct gagctgtgat ggcgagcgaa atatagtagc gaagttcctg 99301 attccacact gccaagaaaa gcctctagcg aggtgagagg tgcccgtacc gcaaaccgac 99361 acaggtaggc gaggagagaa tcctaaggtg atcgagagaa ctctcgttaa ggaactcggc 99421 aaaatgaccc cgtaacttcg ggagaagggg tgctctgtta gggtgcaagc ccgagagagc 99481 cgcagtgaat aggcccaggc gactgtttag caaaaacaca ggtctctgcg aagccgtaag 99541 gcgaagtata ggggctgacg cctgcccggt gctggaaggt taagaggagc gcttagcgta 99601 agcgaaggtg cgaattgaag ccccagtaaa cggcggccgt aactataacg gtcctaaggt 99661 agcgaaattc cttgtcgggt aagttccgac ccgcacgaaa ggcgcaacga tctgggcact 99721 gtctcaacga gagactcggt gaaattatag tacctgtgaa gatgcaggtt acccgcgaca 99781 ggacggaaag accccgtgga gctttactgc agcctgatat tgaatgttgg tacagcttgt 99841 acaggatagg taggagcctt ggaaaccgga gcgccagctt tggtggaggc atcggtggga 99901 tactaccctg gctgtattga ccttctaacc cgccgccctt atcgggcggg gagacagtgt 99961 caggtgggca gtttgactgg ggcggtcgcc tcctaaaagg taacggaggc gcccaaaggt 100021 tccctcagaa tggttggaaa tcattcgcag agtgtaaagg cacaagggag cttgactgcg 100081 agacctacaa gtcgagcagg gacgaaagtc gggcttagtg atccggtggt tccgcatgga 100141 agggccatcg ctcaacggat aaaagctacc ccggggataa caggcttatc tcccccaaga 100201 gtccacatcg acggggaggt ttggcacctc gatgtcggct catcgcatcc tggggctgta 100261 gtcggtccca agggttgggc tgttcgccca ttaaagcggt acgcgagctg ggttcagaac 100321 gtcgtgagac agttcggtcc ctatccgtcg cgggcgcagg aaatttgaga ggagctgtcc 100381 ttagtacgag aggaccggga tggacgcacc gctggtgtac cagttgttct gccaagggca 100441 tcgctgggta gctatgtgcg gacgggataa gtgctgaaag catctaagca tgaagccccc 100501 ctcaagatga gatttcccat tccgcaagga agtaagatcc ctgaaagatg atcaggttga 100561 taggtctgag gtggaagtgt ggcgacacat ggagctgaca gatactaatc gatcgaggac 100621 ttaaccatat ttttgaatga tgtcacatct gttatctagt tttgagagaa cactctcaat 100681 ttgtttggtg gcgatagcga agaggtcaca cccgttccca taccgaacac ggaagttaag 100741 ctcttcagcg ccgatggtag tcgggggttt ccccctgtga gagtaggacg ccgccaagca 100801 agcttaaacc cagctcaatg agctgggttt tttgtatttt ggtttattgg tatcataaaa 100861 ttccacttaa ctgtataata taataacttt ataccgaatt ttaaatcagc aatcaggttt 100921 tgtggaccgg gaaaatggaa ataatgaagg atagagcgag aaagttgaaa attctcgaga 100981 aacggcttat agtaagatta aagtcaaata tagtcaaagt cagtaaagga gggggttgag 101041 tgggacataa tatttctgac atcattgaac aatatttaaa acgagtgtta gatcaaaatg 101101 gcaaggaaat tttagagatt aaacgaagtg aaattgcaga taaatttcaa tgcgttcctt 101161 cccaaataaa ttatgtcatc aacaccagat ttacaagcga aagaggatat attgttgaga 101221 gcaaacgcgg gggcggcggt tacatcagaa tcattaaaat taaaatgaac aatgaagttg 101281 tcctgatcaa taatataatt tctcaaatta atacccattt gtctcaagca gcctctgatg 101341 acattatttt aaggctatta gaagacaagg taatttcaga aagagaagca aaaatgatgg 101401 tcagcgtaat ggaccgctca gttttacaca ttgacttacc tgaacgtgat gaattaagag 101461 cgagaatgat gaaggcaatg ctgacttctt taaaattaaa ataagcgggt gaaaagattg 101521 atttgtcaag agtgccacga gagaccagcc acttttcact ttacaaaggt tgttaacgga 101581 gaaaaaatag aagttcatat ttgtgaacaa tgtgccaaag aaaatagtga ttcatatggt 101641 ataagtgcaa atcagggttt ctctattcat aatttacttt cgggtttact gaacatggat 101701 tcttcatttc aaaatgcagg aactcaaatg ttcagtcact cggagcaaat atctgcttgt 101761 ccgaaatgcg gaatgacttt tcagcaattc agaaaaattg gccgttttgg atgttctgaa 101821 tgttacaaaa catttcatag caacattaca ccaatcctac gtaaagtgca cagcggaaac 101881 actgtgcatg caggtaagat accgaaacga ataggcggca atcttcatgt cagacggcag 101941 attgatatgc taaaaaagga attagaatcc ttaatccatc aagaagaatt tgaaaatgca 102001 gctcatgtaa gagatcaaat tcgtttatta gaacaatcac tcaaaagtac agatagtgag 102061 gaggaacagg agtaatgtcg ctaaagcatt ttattcagga cgcactaagc agttggatga 102121 agcagaaagg acctgaaagt gacattgtac tcagcagccg catacgttta gcaagaaact 102181 ttgagcatat tcggttccct acgcggtatt ccaatgaaga agcctcatcc atcatacagc 102241 aatttgaaga tcagttttca gagcaagaaa ttcccggaat cggcaaattt gttttgatta 102301 gaatgaatga tgcacagcct ttagaaaagc gtgtacttgt tgaaaaacat ctaatcagcc 102361 cgaatttgac agagtctcct tttggcggct gtttgctttc tgaaaatgag gaagtaagcg 102421 tcatgctaaa tgaagaggac catattagaa ttcagtgtct tttccctgga tttcagcttt 102481 tagaagcaat gaaagccgca aaccaggtcg acgactggat tgaagaaaaa gttgattatg 102541 cattcaatga gcaaagagga tacttaacca gctgtcctac aaacgtaggt actggtttaa 102601 gggcttcggt catgatgcat ctgccggcgc tggttttaac taggcaaata aatcgaatta 102661 taccggcaat taatcaatta ggcttagttg ttagaggaat ttatggggaa ggcagcgaag 102721 cagtagggaa tatctttcaa atttcaaatc agatcacgct tggtaagtca gagcaggata 102781 ttgtagagga tcttaacagt gttgctgctc agttgattga acaagaacga tctgcccgag 102841 aagcgattta tcaaacttct aaaatcgaac ttgaggatcg ggtatatcgg tcatatgggg 102901 tcttgtctaa ttgccggatg atagaatcga aagaaactgc aaagtgcctt tcagatgttc 102961 ggttaggcat agacttaggc ataataaaag gactttcaag caacatactt aacgaactta 103021 tgattttgac gcagccaggg tttttacagc aatactcggg aggcgctttg cgaccgaacg 103081 aaagggacat tcgaagagcg gctctcatca gagaacggct tcacttagaa atgaatggga 103141 aaagacagga ggatgaatcg atatgatgtt tggaagattt acagaacgag ctcaaaaagt 103201 actggcgcta gcacaggaag aagcacttcg gttaggtcat aataacattg gcactgagca 103261 tattttatta ggactggtaa gagaaggaga gggcattgct gctaaagctc ttcaagcgct 103321 tggactcggt tcagaaaaaa ttcagaaaga agtagaaagt ttgatcgggc gcgggcagga 103381 aatgtctcaa acgattcatt atactcctag agctaaaaaa gtcattgagc tttcaatgga 103441 tgaggcaaga aaactcggtc attcttatgt gggaacagaa catattcttc ttggtctgat 103501 tcgtgaagga gaaggtgttg ctgcgagagt tctgaataat ctcggtgtca gcttaaataa 103561 agcaagacag caggtgctcc agcttctagg aagtaatgaa acaggatcat cagcggcagg 103621 aacaaacagc aatgcgaata cgcctacgct tgacagcttg gcaagagact taactgctat 103681 tgcgaaggaa gacagccttg accctgtaat cggcagaagc aaggagatcc agcgtgtcat 103741 tgaagtgtta agccgcagaa cgaaaaacaa ccctgttctc attggggaac caggtgtagg 103801 taaaacggct atcgcagaag gtttggcaca gcaaattatc aataatgaag tacccgaaat 103861 tttgcgtgat aaacgtgtga tgacattaga catgggaaca gttgttgccg gcacaaaata 103921 ccgcggagaa tttgaggatc gcctgaagaa ggtcatggat gaaattcgcc aggcaggaaa 103981 tatcattcta ttcatcgatg agctccatac attaatcggg gcaggcggag cagaaggtgc 104041 tattgatgca tctaatattt taaaaccttc acttgctcgt ggcgaactcc aatgtattgg 104101 tgcaacgact cttgatgagt accgtaaata tattgaaaaa gatgcagcac tggaacgccg 104161 ttttcagccg attcaggttg atcagccatc tgtagatgaa agtattcaaa ttttacaagg 104221 tctgcgtgac agatacgaag cccaccaccg cgtttctatc actgatgatg ccattgaagc 104281 tgcggttaag ctttctgaca gatatatttc tgaccgcttc cttccggata aagcaattga 104341 cttgatcgat gaagcgggtt caaaggtgag actgcgctca tttacaacgc ctcctaactt 104401 aaaagagctt gagcagaagc ttgatgaggt tcgtaaagag aaggatgcgg cagtgcaaag 104461 ccaagagttt gaaaaagctg cttccttgcg tgatactgaa caacgcctgc gcgagcaagt 104521 agaggatacg aagaaatcat ggaaagagaa gcaagggcag gaaaactcag aggttactgt 104581 ggatgatatt gcgatggttg tatccagctg gaccggtgtg cctgtatcta aaatcgccca 104641 aactgaaact gataagcttc tcaatatgga aaacattctt cactcccgtg tcatcggcca 104701 ggatgaagca gttgtagcgg ttgcaaaagc cgtcagacgt gcaagagcag gattgaaaga 104761 tcctaaacgc ccaatcggct cattcatttt cttaggccct acaggtgtag gtaaaacaga 104821 acttgcacga gcacttgctg aatccatttt tggcgatgaa gaatccatga tcagaattga 104881 tatgtctgaa tacatggaaa aacattcaac ttcaagactt gttggttcac ctccgggtta 104941 tgtgggatat gatgaaggcg gtcaattgac agagaaagtc agaagaaaac cttactctgt 105001 cgtgcttctt gatgagatcg agaaagcgca ccctgatgtc ttcaatatcc ttctgcaagt 105061 tcttgaagac ggacgattga ctgattctaa aggacgcaca gtcgatttcc gcaataccat 105121 tctgatcatg acatcaaacg tcggagcaag tgagctaaaa cgcaataaat atgtcggctt 105181 taacgttcag gatgaaactc aaaatcataa agacatgaaa gataaagtga tgggtgaatt 105241 aaaacgagcg ttcagacctg agttcatcaa ccgtattgat gaaatcattg tcttccattc 105301 acttgagaaa aaacatctca ctgagattgt gtcattaatg tctgatcaat taacgaaacg 105361 cctgaaagaa caagatcttt ctatcgaatt gacagatgct gcaaaagcga aagtcgcgga 105421 agagggcgtt gacctggaat acggtgcccg tccgttaaga agagcgatcc aaaaacatgt 105481 cgaggatcgt ttatctgaag aactcctcag aggaaatatt cataaaggac agcatattgt 105541 tcttgatgta gaagatggcg aatttgtcgt aaaaacgact gctaaaacga attaatatag 105601 aagacggaaa tgaggcatac agcatgtaag tgtatgcctc actttcatat caagaaatag 105661 aacaagggag aggtcttaca ctatatatgg ctaaaacaaa atcgaagttc atctgccaat 105721 cctgcggcta cgagtctcca aaatggatgg ggaaatgtcc gggctgtggt gcttggaata 105781 caatggtgga agaaatgatt aaaaaagcac cggccaatcg gagagcggct ttttctcatt 105841 ctgttcaaac tgtacagaaa ccttcaccta ttacatcaat cgaaacatca gaagaacccc 105901 gcgtcaaaac ccagcttggc gagtttaaca gagtactcgg cggaggtgtc gttaaaggct 105961 ccctcgtttt aattggcggt gatcctggta tcggaaagtc aacgctatta ctgcaggttt 106021 ccgctcaatt atcaggctca tcaaacagtg tcctgtatat ttcgggagaa gaatctgtaa 106081 agcaaacgaa gctgcgagca gaccgtctcg gcattaataa tccgtcactg catgttttat 106141 ctgaaaccga tatggagtat atttcgtctg ctatacaaga gatgaatcca tcgtttgtcg 106201 ttgttgactc tattcaaacg gtttaccaaa gcgatattac atctgctcca ggcagtgtgt 106261 cacaggtcag agaatgtacc gctgagctga tgaaaattgc aaaaacaaaa ggtattccga 106321 tttttatcgt agggcacgtg acgaaagaag ggtctattgc aggtccgaga ctgttggagc 106381 atatggttga cactgtttta tattttgaag gagaacgcca ccatactttc cgtattttgc 106441 gggctgtaaa aaaccgtttc ggatctacaa acgaaatggg cattttcgaa atgcgggaag 106501 aggggctcac tgaggttttg aatccttcgg aaattttctt agaagaacgc tctgctggtt 106561 ccgcaggctc gagtatcact gcctctatgg agggcactag accgattctc gttgaaattc 106621 aggcactcat ctcgccaaca agttttggca acccaaggcg tatggcaacg ggaatagacc 106681 ataacagggt ttctctgtta atggctgtgt tagaaaaaag agttggactg ctgctgcaaa 106741 atcaggatgc ttatttgaaa gtggctggcg gcgttaagct tgatgaaccg gcaattgatc 106801 ttgcgattgt gattagtatt gcatcaagct ttagagacac acctccaaat cctgcagatt 106861 gttttattgg agaagtggga ttaaccggag aagtccggcg ggtttcaaga attgaacagc 106921 gtgtgaaaga agcggcaaag cttggtttta aacgcatgat catacccgcg gcaaatctgg 106981 atggatggac aaaaccaaaa gggattgagg ttatcggagt agcaaatgtt gcagaagcgc 107041 ttcgtacttc attaggagga taatagatgg aaaaagagaa aaaaggggcg aaacacgagt 107101 tagacctgtc atctatattg cagtttgttg ctccgggtac accgctcaga gcggggatgg 107161 aaaacgtctt gagagcaaat acaggcggtc tgattgttgt tggatataat gataaagtaa 107221 aagaagtggt ggacggcggc tttcacataa acacggcttt ttctccggcg catttatatg 107281 agctggctaa aatggatgga gcgatcattt taagtgattc tggtcaaaag atcctatacg 107341 cgaatactca gctgatgccg gatgccacaa tttcttcatc agaaacagga atgcggcaca 107401 gaactgccga aagagtagct aagcaaactg gctgtcttgt aatcgccatt tctgaaagaa 107461 gaaatgtcat aacgttatat caggaaaaca tgaagtatac actaaaagac ataggattta 107521 ttttaaccaa ggcgaaccaa gccattcaaa cacttgaaaa atataagaca atcctcgata 107581 aaacgattaa tgcactgaac gcgttagagt ttgaggaact tgttaccttc agtgatgtct 107641 tgtctgtcat gcatcgttat gaaatggtac tgagaatcaa aaacgaaatt aatatgtata 107701 tcaaagagct ggggacagaa gggcatctga tcaaactgca agtcattgaa ttgattacgg 107761 atatggaaga agaggccgct ttatttatta aggactatgt aaaagaaaag attaaagatc 107821 cgtttgttct cttgaaggag ctgcaggata tgtccagtta tgatctgctg gatgattcca 107881 ttgtgtataa gcttctcggt taccctgctt ctactaatct tgatgattat gtattgccga 107941 gaggatacag gctgttaaat aagataccgc gtcttccgat gccgattgtt gaaaatgttg 108001 tagaagcatt tggagtcctg ccaaggatta ttgaggcgag tgcagaagaa ttagatgaag 108061 tagagggaat cggtgaagta cgagcccaaa aaatcaaaaa aggattaaaa cgcctgcaag 108121 agaagcatta tttagacaga caactgtgat ttcggttaaa accttatgaa tacgggtata 108181 ttaatgttgg tttttgttta ttctgatatt cgtaggatgc ataagacttt gtgaaattaa 108241 aatgttaaaa aaggaggtgg gggtatgtta aaacgaatag ttcaggcgtt cttcattatt 108301 tttggcggcg ttgttggtat atttttgata cctgaattgt ttgtactgtt aaatatacag 108361 gacatacctt taataacaaa cgcatatacg tctgcggcaa taggagcaat tatctttttt 108421 ctcatcagta tatggggtac agaatacgtt gtgaactggg tgaagtggat agaggattca 108481 ttgttaaaag cgccggttcc agatttgtta tttggaagtc ttggcttagt ttttggactt 108541 ataattgctt atcttatcgt aaatgttatt cctttagaca atatacctta ccgcatattc 108601 agcacaataa ttcctgtatt tttggctttc ttcctcggtt atctcggctt ccaggtgggc 108661 tttaagaaaa aggatgaatt gatcagcctg ttttccattt ccgccagaat gcaaaagaaa 108721 aaaggaacag ctgatgaaga acatgaggtt caagacaaga agctgaaaat tttggacact 108781 agtgttatta ttgatgggag aatagcagat atttgtcaga ctggtttttt agagggagtt 108841 atcgtgattc cgcagtttgt ccttgaggaa ttgcagcata ttgcagactc ttcagatgtt 108901 ttaaaacgaa acagaggacg ccgcggtctt gatatcctga accgcattca gaaagaatta 108961 gacattgaag ttgaaattta cgaaggcgac tttgaagata ttcaggaggt tgacagcaag 109021 ctcgtcaaac ttgctaagct gacatccggg gtcgttgtga cgaatgattt taatttaaat 109081 aaagtgtgcg agcttcagaa ggtagcagta ttaaacatta atgaccttgc caatgcggtt 109141 aagcctgttg tgcttcctgg cgaggaaatg aatgttcagg tcattaagga cgggaaagag 109201 cataatcagg gagttgccta cttggatgac ggtacgatga ttgtcgttga agaaggacgg 109261 aattatatcg gcaagcatat tgatgtactc gtcacaagtg tgctgcagac agcagcggga 109321 cgaatgattt ttgcgaagcc taagctgttg gagaaggcgc tgtaaaggga gaagaaacaa 109381 tgagttatga tgtggtgatt cctgcagccg gacagggaaa gcggatgaag gcagggagaa 109441 ataaactgtt cattgagctg aagggagacc cggtgatcat acacacgtta agagtgtttg 109501 acagccaccg gcagtgcgat aaaatcattt tggtgattaa cgagcaggag cgggagcact 109561 ttcagcaatt gctgtccgat tacccgtttc aaacttcaat tgagcttgtt gcaggcggag 109621 atgagcgaca gcacagtgtg tataaggggc tgaaagccgt aaagcaggaa aagattgtcc 109681 ttgtacatga cggtgcccgt ccatttataa aacatgaaca aattgacgaa ctgatcgcag 109741 aggcggaaca gacaggagcg gccatccttg ctgttccggt aaaagatacg attaaacgcg 109801 ttcaagattt acaagtcagt gagacgattg aacgttcaag cttgtgggct gtccaaacgc 109861 cacaagcttt tcgtctttct ttattgatga aggctcacgc tgaggccgag cgcaagggat 109921 ttttagggac ggatgacgcc agcctcgttg aacagatgga gggcggttcg gtccgtgttg 109981 tagaaggcag ctatacaaat attaagctga cgacgccaga cgatttgacg tcagctgaag 110041 ctatcatgga atcagaaagt gggaataaac atgtttagaa ttggacaagg atttgatgtg 110101 catcaattag tggagggccg tcctctcatt attggcggaa ttgaaatccc gtacgaaaaa 110161 gggctgcttg gccattctga tgcagacgta ttgttgcata ccgtcgctga cgcctgcctg 110221 ggagctgtgg gtgaaggaga cataggcaag cattttcctg acacagatcc cgagttcaag 110281 gacgcagatt ctttcaaatt acttcagcat gtctggggaa tcgtgaaaca gaaggggtat 110341 gtccttggga acattgattg caccatcata gcgcaaaagc cgaagatgct gccgtacata 110401 gaagatatga gaaaaagaat tgctgaaggc cttgaggcag atgtttctca agtaaatgta 110461 aaagcaacaa cgacagaaaa gcttggattt acaggccggg cggaaggaat agcggctcag 110521 gcgacagtac tgatacaaaa aggctaactt gttttgatgc cgggtctatt tggtggtaga 110581 atagattcat acatttttgc ctgaggccat acatgacatg aaaggaagta tttgaaaatg 110641 ggaaacgaag tacgcgtccg ttatgcaccg agtccaaccg gacatttgca tattggaaat 110701 gccagaacgg cgctttttaa ttatttattt gcccgcaatc aaggcggtaa gtttatcatt 110761 cgagttgagg atactgataa aaagcgcaat attgagggcg gagaacaaag ccagctgaat 110821 tatctgaagt ggctaggtat tgactgggat gagagtgtgg atgtcggagg agagtacggt 110881 ccataccgtc agtcagagcg taacgatatc tataaagtgt actatgaaga gcttcttgaa 110941 aaagggcttg cttataaatg ttactgtacg gaagaagagc ttgaaaaaga gcgtgaagaa 111001 cagattgccc gcggagaaat gcctcgttat tccggaaaac acagagacct gactcaggaa 111061 gaacaggaga aatttatcgc cgaaggcaga aaaccaagta ttcgtttccg tgtgccggaa 111121 ggaaaagtca tcgccttcaa cgacatcgta aaaggcgaaa tttcttttga atcagatggc 111181 atcggcgact tcgttattgt gaaaaaggac ggaacgccta cttataactt cgcggtagct 111241 attgatgact acttaatgaa aatgacacac gtgctgcgcg gtgaggatca tatttctaac 111301 acaccgaaac agattatgat ctatcaagca ttcgggtggg atattcctca gttcggacac 111361 atgacgctga ttgtaaacga aagccgtaaa aagctcagca aacgtgatga atccattatt 111421 caattcatcg agcagtacaa agagcttggc tacctgccag aagcgctgtt caactttatc 111481 ggcttgttag gctggtcacc ggttggagaa gaagagcttt tcacaaaaga gcagtttatt 111541 gaaatttttg atgtaaatcg tttatctaaa tcaccagctt tgtttgatat gcataagcta 111601 aaatgggtta acaaccaata tgtgaagaag ctggatcttg atcaggttgt tgaactgacg 111661 cttccgcatt tgcaaaaagc cggcaaagtt ggcactgagc tttctgctga agaacaagaa 111721 tgggttcgta aactgatttc cctgtatcat gagcaattaa gctacggtgc ggaaattgtt 111781 gagctgactg atttgttctt tacggatgag atcgagtata atcaagaagc gaaagctgtt 111841 ctggaagaag aacaggttcc tgaagtgctc agcacattcg cagcgaagct tgaagagctt 111901 gaggagttca ctccggataa tatcaaagca tcgatcaaag cagtgcagaa agaaactggc 111961 cataaaggga aaaaactgtt tatgccgatt cgtgttgctg taacagggca aactcacggt 112021 ccggaactgc cgcaatcaat tgaattgatc ggtaaagaga ctgcaattca gcgtttaaag 112081 aatatctaaa taaatgattg ttgacaggga agagtataaa gctttaggcc attacagaaa 112141 ggatcttcat tggctgagag agatccatga gccgggtttt agaagtgcgc ccttaagacc 112201 tttgaagaac gttttttgaa atcagtattc aaaggcggcc gccgccgtta caggctgaag 112261 ttgggagagc agaagtctgc ttttcaaaca gagtggaacc gcgcggttaa agcgtctctg 112321 tcatgtttac atgcagagac gcttttttta ttgggtagag gaaatcagat agagaaacgg 112381 ggggaagcat gtgtttttta gaatgctcaa agaagacatt gatactgtgt tcgatcaaga 112441 tcccgcagca agaagctatt ttgaagtgat tttaacttat tccggtttac atgctatatg 112501 ggcgcatcgg attgcacatg ctttatataa acgaaaattt tatttccttg cacgccttat 112561 atctcaagta agccgatttt ttaccgggat agaaatccac cccggcgcta caatcgggag 112621 aagatttttc atagaccacg gcatgggggt tgtcattggg gagacatgtg aaatcggcaa 112681 taacgtaacc gtttttcagg gggttaccct cgggggaacg ggaaaagaaa agggaaaaag 112741 gcacccaacg attaaagatg acgcattgat agccacaggt gctaaagtgc tcggttctat 112801 tacggtcggt gaaggctcaa agattggcgc tggttcagta gtgctgcatg atgttcctga 112861 tttttcaaca gttgtcggta tccctggacg ggtcgttgta caaaatggca agaaagtaag 112921 acgcgattta aaccatcagg atttgcccga tccagttgct gaccgcttta agtctttgga 112981 acagcagatt ttagagctga aggcagaact tgaagacaga aaagaaagga tcaatcaaaa 113041 atgacaatca cactttataa tacattgact agacagaagg aaacattcgt tcctcttgaa 113101 gagggaaaag tgaaaatgta tgtatgcgga cccacggttt acaattacat tcatatcggg 113161 aacgcgcgtc cggcaatcgt ttacgatacg gttcgaaact atttagagta taaaggctat 113221 gatgtgcagt atgtctctaa cttcacagac gtagacgata aattaattaa agcggcaaat 113281 gaactcggtg aggatgtacc caccatttca gagcgtttta ttaaagcata ctttgaagac 113341 gtaggtgcgc tcggctgccg aaaagccgac cttcatccgc gagtaatgga gaacatggat 113401 gccattatcg aattcgtaga tcagctcgtg aaaaagggct acgcatatga atcagaaggt 113461 gacgtatatt tcaaaaccag agcatttgaa gggtacggaa agctttctca gcaatcaatc 113521 gatgaactaa gatcaggtgc acgcatccgg gtcggcgaga aaaaagaaga tgctcttgat 113581 ttcgcactgt ggaaagcggc aaaagaagga gaaatctctt gggatagccc ttgggggaaa 113641 gggcgtccgg gctggcacat tgaatgctca gcaatggtga aaaagtatct cggtgaccag 113701 attgatatcc atgcgggcgg acaggattta acattccctc accatgaaaa cgaaattgcg 113761 caatctgagg cgctgacagg caaaacgttt gcgaagtact ggcttcataa tggttatatc 113821 aatattgata atgaaaaaat gtcaaaatca ctaggcaact ttgtgcttgt gcatgacatc 113881 attaaacagc atgatccgca gcttttgaga ttctttatgc tatctgttca ttatcgccat 113941 ccgattaact attcagaaga gcttctggag aatacgaaaa gcgcgttcag ccgtttaaaa 114001 acagcgtaca gcaatcttca gcaccgtctg aacagcagta cgaatttaac cgaagatgac 114061 gatcaatggc ttgaaaaggt tgaagaacac cgcaaagcat tcgaagaaga gatggacgat 114121 gattttaata cggcgaatgc catttcagtc ttgtttgact tagcgaaaca cgccaattat 114181 tatcttcaga aagatcatac ggctgatcat gtgattacgg cgtttattga gatgtttgac 114241 cgcattgttt ctgtcctcgg tttttcgttg ggtgagcagg aacttctcga tcaagagatt 114301 gaagacttaa tcgaaaagcg aaatgaagcg cgccggaatc gcgattttgc attgtcagac 114361 cagatccgcg accagctgaa aagcatgaat atcattcttg aagatacggc tcaaggcact 114421 cgctggaaac ggggagaata acagatgctt gaatttgata cgataaaaga ttctaagcag 114481 cttaacggtc ttgcgcttgc ttatataggt gatgccattt ttgaagtgta tgtcaggcat 114541 cacctgctta agcagggctt taccaaacca aatgatcttc ataagaaatc aagccggatt 114601 gtttcagcaa agtcacaggc tgagatccta ttttttctgc agaatcaatc attttttacg 114661 gaagaagagg aagcggtgct gaaaagaggc agaaatgcca agtcagggac aacacctaaa 114721 aatacagatg ttcagacgta ccgctacagt acagcatttg aagcgcttct gggctacctt 114781 tttctagaga aaaaagagga acgacttagt cagctcgtag ccgaagctat acaattcggg 114841 acgtcaggga ggaaaacaaa tgagtcagca acatgattac gtcataggga aaaatgcagt 114901 gatcgagacg ttaaaatctg atcggaagct gtataagctg tggatggcgg aaaacaccgt 114961 aaagggacaa gcacagcaag tgattgagct tgccaaaaag cagggaatca cgattcaata 115021 cgtcccgaga aaaaaactcg atcaaatggt gacaggacag catcagggcg tagtggcaca 115081 ggttgcagcg tatgaatatg cagaactgga cgatttatat aaagcagccg aagaaaaaaa 115141 tgaacagcct ttcttcctca ttctggacga gcttgaagac cctcataatc ttggttccat 115201 tatgaggaca gcagatgcgg tcggcgctca tggcatcgtc attccaaaac ggagagctgt 115261 cgggctgaca acaacagtgg caaaagcttc aacaggagca attgagcaca ttcctgtagc 115321 aagagtcacc aatttggcac ggacgttaga agagatgaaa gagcggggaa tctgggttgt 115381 cggaacggat gcgtccgcgc gtgaggattt ccgtaatatg gacggcaata tgcctttggc 115441 tctagtcatc ggaagtgaag gaaaagggat gggccgcctt gtgaaggaaa agtgcgattt 115501 tctcattaaa ctcccgatgg ccggaaaggt aacttcacta aatgcatctg tcgcggctgg 115561 tcttttgatg tatgaagtct accggaaacg aaaccctgtg ggagaataaa gacccatgga 115621 tatcctgtta gtagacgggt acaacatgat tggagcctgg ccgcagctga aggatttaaa 115681 agcgaacagt tttgaagagg cgagagacgt actgattcag aaaatggcgg aatatcaatc 115741 gtatacagga aacagggtta ttgttgtttt tgacgcgcat ctcgtaaaag ggcttgagaa 115801 aaaacagacc aaccatagag ttgaagtaat ttttacaaaa gaaaatgaga cggctgatga 115861 gcggatagaa aagctcgctc aggctttgaa taatattgcg actcaaattc acgttgcgac 115921 ctctgactat actgagcagt gggcgatttt cggacagggg gcattgcgga aatcggcccg 115981 ggagcttctg agagaggtag aaacgattga aaggcgaata gagagacggg taagaaaaat 116041 cacttccgaa aagccggcgg gtaaaattgc tttatcggaa gaggttttga aaacgtttga 116101 aaagtggagg cggggagact tagattaagt tgacgctttt ttgcccaata ctgtataata 116161 tttctatcta cgtgcgccgg ggggatcgga gtgaatctac agaacaacaa gggaaaattc 116221 aacaaagagc agttttgcca gttggaggac gagcaggtca ttgaaaaggt tcatgttggg 116281 gacagtgatg cgttagatta cttgattacg aagtaccgaa actttgttcg ggcaaaagca 116341 agatcctatt tcttaatagg ggcggacaga gaggatattg ttcaggaagg catgataggc 116401 ctctataagt ctattcgtga cttcaaagag gacaagctta cctcattcaa agcttttgca 116461 gaattatgta ttacccgcca aattattacc gcaataaaga cagctactcg ccagaaacac 116521 attcctttga attcctacgc ctcattagat aaaccgatct ttgatgaaga atcagaccga 116581 acgctgctgg atgtcatttc aggagcgaaa accttaaatc ctgaggaaat gatcattaat 116641 caggaagaat ttgatgatat tgaaatgaaa atgggagaac tattaagtga tttagagaga 116701 aaagtactcg tcttatatct cgacgggaga agttaccaag agatttctga tgaactgaac 116761 cgacatgtga aatcgatcga caatgccctt cagcgtgtga aacgcaagct ggagaagtac 116821 ttggaaattc gcgaaatcag tttgtaatag gaatttatgc tatattgaca gtatttttct 116881 gactatgata tgttactaaa gataagaact aatgtctatt tagaaaaagg tgtaatgaca 116941 tgagaaaaaa gattacgtta gcatgcaaga catgcggaaa ccgtaattat acgacaatga 117001 agagctctgc atcagcggct gagcgattag aagtaaagaa atactgcagt acttgcaatt 117061 cacatacagc tcatcttgaa acaaaatagt ttttgcgctt ttaaattgtg gaggtctttt 117121 acatgcgtat tatgaaattc tttaaagatg ttgggaaaga aatgaaaaag gtaagctggc 117181 ctaaaggaaa agagttaacg cgttatacca ttacggtaat ttcaacagtt atcttttttg 117241 ttatcttttt tgccctcctt gacacaggaa tttctcaatt aattcgttta atagttgaat 117301 aatgatcagc aatacgtgct ataatagatc ataatattac ttgccaaaac ccgttcagcg 117361 ggttttttat tgtggcttaa aatgaaagtt atcataggct tgccgcctat tttttgaagc 117421 gttatggtaa ttcactaaaa ccaaatgcgg ggagggaagg actggacagt cctgaataga 117481 atggaaaaga attggtatgt tgttcacacg tactctggtt atgagaataa agtaaaagcc 117541 aacttggaaa agcgtgttga atcaatgggg atgcaggata aaattttccg tgtagtcgta 117601 cccgaagaag aagaaacgga tatcaaaaac ggcaagaaaa aagtcgtgaa aaagaaagta 117661 ttccctggtt atgtgcttgt tgaaattgta atgacagacg actcttggta tgtcgtccgc 117721 aacacgccgg gcgttactgg attcgtagga tctgccgggt caggttcaaa accgacgccg 117781 cttcttccgg gggaagcaga aaccattctg aagagaatgg gcatggatga acgaaaaact 117841 gatattgact ttgaactgaa agagacagtg aaagtaatag acggaccttt tgctaacttt 117901 acaggatcaa ttgaagagat tgattatgat aaaagcaagg tcaaagtttt cgttaatatg 117961 tttggccgtg aaacgccggt tgagctggaa tttacccaaa tcgataaatt gtaatgtgaa 118021 aaaacttgaa attgctatat ataaatgata atatagcaaa ggtacgtctt ggacttatcc 118081 aaggcaacta gcatgatatt tcgtcattca tataaagaat gaaaccttga gtgggagggt 118141 ttaccctatt accacatcac ggacttaagg aggtgtgtct cgtggctaaa aaagtagtta 118201 aagttgtaaa attgcaaatt cctgctggaa aagctaaccc agcaccacca gttggacctg 118261 cacttggtca agccggtgtt aacatcatgg gattctgtaa ggagtttaac gctcgtacag 118321 ctgaccaagc tggtttaatc attcctgttg aaatttcggt ttacgaagac cgttcattta 118381 catttattac aaaaactcca cctgctgcag tattgcttaa aaaagcagct ggaattgagt 118441 ctggttctgg tgaaccaaac cgtaataaag tggcaaccgt taagcgcgat aaagtacgcg 118501 aaatcgctga aacgaaaatg cctgacttaa acgcagcaga cgttgaagcg gcaatgcgca 118561 tggttgaagg tactgcccgc agtatgggta ttgtaatcga ggattaattt gtttcttgtc 118621 gggttgcgag ttttaacaag ttcgcaaccc ttattcgtgg gaggttattc cgctataacc 118681 acataaggag gaaattttaa aatggctaaa aaaggtaaaa agtacgttga agctgctaag 118741 cttgtagacc gttctaaagc ttacgacgtc tctgaagcag tagctctcgt taaaaaaaca 118801 aacacagcta aattcgacgc tacagttgaa gtggctttcc gtttaggggt tgaccctcgt 118861 aaaaacgacc agcaaatccg tggagcagtt gtgcttccaa acggaactgg taaaactcag 118921 cgcgttctcg ttttcgcaaa aggcgaaaaa gcgaaagaag ctgaagctgc tggtgcagat 118981 ttcgtaggcg atactgacta catcaacaaa attcaacaag gctggttcga tttcgatgtt 119041 atcgtagcta cacctgacat gatgggtgaa gttggtaaaa tcggtcgtgt acttggacca 119101 aaaggtttaa tgccgaaccc taaaactggt acagttactt tcgaagttga aaaagctatc 119161 ggcgaaatca aagctggtaa agttgaatac cgcgttgata aagctggaaa cattcatgtt 119221 cctatcggta aagtttcttt cgaggatgaa aaacttgttg agaacttcac aacaatgtac 119281 gatacaatcc ttaaagctaa acctgctgca gctaaaggcg tttacgtgaa aaacgttgct 119341 gtaacttcta ctatgggacc tggtgtcaaa gtagactctt caacttttaa cgtaaaataa 119401 tattgacatg acatcaacat tctgatatta ttcaaaatgt tgtaaaatag aatatcattt 119461 ataccgtaga cagtaggggc ctaaccgctt aattatccta ccgaggtgta tattatcaca 119521 gctattacgt tacgtatgct tgtatataca gcctccatgt ctcatggagg ctttttatat 119581 ggaatccgtc gtctcagtcg tgatcaccta acggtataag tgttacacaa gaatctacag 119641 gaggtgtaac catgagcagc gcaattgaaa caaaaaaagt tgttgttgaa gaaattgctt 119701 ctaaactgaa agaaagtaaa tcaacgatca tcgttgacta tcgcggactt aacgtttctg 119761 aagtaactga acttcgtaaa cagcttcgcg aagctaacgt tgagttcaaa gtttacaaaa 119821 atacgatgac tcgccgtgcg gttgaacaag ctgagcttaa tggtttgaat gatttcttaa 119881 ctggaccgaa cgcgatcgca ttcagcactg aagatgttgt cgctccggct aaagttctta 119941 atgacttcgc taaaaatcac gaagctcttg aaatcaaagc tggcgttatc gaaggtaaag 120001 tttctactgt tgaagaagtg aaagctcttg ctgaacttcc atcacgcgaa ggcttgcttt 120061 ctatgttgct tagcgtactt caagctccag ttcgcaacct tgctcttgct gcaaaagctg 120121 tggcagaaca aaaggaagaa caaggcgctt aatctaatca gtttttcata aattaaaaca 120181 aaatggagga attacaaatg gctttaaata tcgaagaaat cattgcttcc gttaaagaag 120241 caactgtact tgaattgaac gacctagtaa aagcaatcga agaagaattt ggcgtaactg 120301 ctgctgctcc tgtagctgta gctggcggag ctgctgctgg cggagctgct gaagagcaaa 120361 gcgaattcga tcttatcctt gctggtgcag gatctcaaaa aatcaaagtt atcaaagttg 120421 tacgtgaaat cactggtctt ggcttgaaag aagctaaaga gcttgttgac aacactccaa 120481 aaccacttaa agaaggtatt gctaaagaag aagctgaaga gcttaaagct aaacttgaag 120541 aagttggcgc ttctgtagaa gttaagtaat cttcacttac ctgtagggga agctcgcttt 120601 tatgaggcga gctttttctt tgccattctt taagccatga aaaaaggagg ttctaataat 120661 gagtgagcac tattattcag aaaaaccttc agtaaaaagc aacaagcaaa cctggtcttt 120721 taggcttcgg aataaagatt tcacgtttac cagcgacagc ggggtttttt ctaaaaaaga 120781 agttgatttc ggctcccgcc tgctgattga ttcttttgaa gagcctgagg ttgagggcgg 120841 cattttagat gtaggctgcg gatacggccc gattggttta tcgctcgcca gcgactttaa 120901 agaccggacc atccacatga ttgacgttaa tgagagagcc gtagaactat caaatgaaaa 120961 tgcggaacag aacggaataa caaacgttaa gatttatcaa agcgatttgt tttcaaacgt 121021 tgattctgct caaacatttg cttctattct tacaaatccc ccaatccgag ccggaaaaaa 121081 agttgtccat gctatctttg agaaaagcgc tgaacactta aaagcttcag gtgaattgtg 121141 gatcgtcata cagaaaaagc aaggcgcgcc ttctgccatt gaaaagctcg aggaactgtt 121201 cgatgaagtt tccgtcgttc aaaaaaagaa aggctattat atcataaaag caaaaaaagt 121261 ttgactcggt attttaacta tgttaatatt gtaaaatgcc aatgtatata ttttgcttga 121321 tatgatgaat tgtcaatatc tatgtataaa ttatacaagt atggaaatgc taataaaatc 121381 ggtatttgtt tttggatgtg gttttcttaa ttagaaaccc ttttttcttt tgtcttgtaa 121441 aagtattttc tttctttgga agaaatgctt attacacata taatacgcat gatttgaggg 121501 gtgaatcagt tgacaggtca actagttcag tatggacgac accgccagcg cagaagctat 121561 gctcgcatta gcgaagtgtt agaattacca aatctcattg aaattcaaac ctcttcttat 121621 cagtggtttc ttgatgaggg tcttagagag atgtttcaag acatatcacc aattgaggat 121681 ttcactggta acctctctct tgagttcatt gattatagtt taggtgagcc taaatatcct 121741 gtagaggaat caaaagaacg tgatgtgact tactcagctc cgctaagagt gaaggttcgt 121801 ttaattaaca aagaaactgg agaggtaaaa gaccaagatg tcttcatggg tgatttccct 121861 attatgacag atacaggtac ttttatcatt aacggtgcgg aacgtgttat cgtttcccag 121921 cttgttcggt ctccaagtgt atatttcagt ggtaaagtag acaaaaacgg taaaaaaggt 121981 tttaccgcaa ctgtcattcc aaaccgtggc gcatggttag aatacgaaac tgatgcgaaa 122041 gatgttgttt atgtccgcat tgatcgcaca cgtaagttgc cggttacggt tcttttgcgt 122101 gctctcggct tcggctccga tcaagagatt cttgatctca taggagaaaa cgaatacctg 122161 cgaaatacgc ttgataaaga taacacagaa aacagcgaca aagcgttgct ggaaatttac 122221 gagcgtctcc gtcctggaga gccgcctaca gtagaaaatg cgaaaagctt gcttgattct 122281 cgtttctttg atccgaaacg atacgatctt gccaatgtag gacgctataa aattaataaa 122341 aaacttcata ttaagaatcg cctcttcaat cagagacttg ctgaaacgct tgttgatcct 122401 gaaacaggag aaatccttgc tgaaaaaggc cagattcttg atagaagaac gcttgataaa 122461 gtactgccat acttagaaaa cggaatcggt tttagaaagc tgtatccgaa tggcggcgtt 122521 gttgaagatg aagtgactct tcaatcaatt aaaatctttg ctccgactga tcaagaagga 122581 gaacaggtta tcaatgtaat cggcaatgct tacatcgaag aagagattaa aaacatcacg 122641 cctgctgata ttatttcttc aatcagctac ttcttcaacc tgctgcacgg agtaggcgac 122701 acagatgata tcgatcatct tggaaaccgc cgtttacgtt ctgtaggcga gcttctccag 122761 aaccaattcc gtatcggttt aagccgtatg gagcgtgtgg ttcgtgagag aatgtcaatt 122821 caagatacga atacaattac gcctcagcag ctgatcaata ttcgtcctgt tattgcgtcc 122881 attaaagagt tctttggaag ctcacagctt tctcaattca tggatcagac gaacccgctt 122941 gctgaattaa cgcacaagcg tcgtctgtca gcattaggac cgggcggatt gacacgtgag 123001 cgtgccggaa tggaagtgcg tgacgttcac tactcccact atggccgtat gtgtccgatt 123061 gaaacgcctg agggcccgaa catcggtttg atcaactcac tatcatctta tgcaaaagta 123121 aaccgttttg gctttattga aacgccatat cgccgcgttg accctgaaac agggaaggta 123181 acgggcagaa tcgattactt aactgctgat gaagaggata actatgttgt cgctcaagcg 123241 aatgctcgtc ttgatgacga aggcgccttt attgatgaca gcatcgtagc tcgtttccgc 123301 ggggagaaca ccgttgtttc cagaaatcgt gtagactaca tggatgtatc gcctaagcag 123361 gttgtatctg ctgcgacagc atgtatcccg ttcttagaaa acgatgactc caaccgtgcc 123421 ctcatgggag cgaacatgca gcgtcaggct gtgcctttga tgcagccgga agcgccattt 123481 gttggaactg gtatggaata cgtatcagga aaagactctg gtgccgctgt tatttgtaaa 123541 caccctggta tcgttgaacg cgtagaagcc aaaaacgttt gggttcgccg ttatgaagaa 123601 gtagacggtc aaaaagtaaa aggaaacctg gataaataca gcctgctgaa atttgtccgc 123661 tctaaccaag gtacgtgcta caaccagcgt ccgatcgtaa gtgtcggcga tgaagtggta 123721 aaaggagaaa tccttgctga cggtccttct atggagcttg gtgaacttgc acttggccgt 123781 aacgtaatgg tcggcttcat gacgtgggat ggctacaact atgaggatgc catcatcatg 123841 agtgaacgcc tagtgaagga tgatgtttat acatctatcc acattgaaga atacgaatca 123901 gaagcacgtg atacgaaact tggacctgaa gaaatcactc gcgatattcc aaacgtcggt 123961 gaagatgcgc ttcgcaatct tgatgaccgc ggaatcatcc gtattggggc agaagtaaaa 124021 gacggagatc ttcttgttgg taaagtaacg cctaaaggcg taactgaact gactgccgaa 124081 gaacgccttc ttcacgccat ctttggcgag aaagcccgcg aggttcgtga tacttctctt 124141 cgtgtgcctc atggcggcgg cggaattatc catgacgtta aagtcttcaa ccgtgaagac 124201 ggagacgaac ttcctccagg tgttaaccag ttagtacgcg tatatatcgt tcagaaacgt 124261 aagatttctg aaggggataa aatggccggt cgtcacggta acaaaggtgt tatctctaag 124321 attcttcctg aagaggatat gccttacctt cctgacggca caccaattga tatcatgctt 124381 aacccgctgg gcgtaccatc acgtatgaac atcgggcagg tattggaact tcacatgggt 124441 atggccgctc gttaccttgg cattcacatt gcatctcctg tatttgacgg agcgcgagaa 124501 gaggatgtct gggaaacact tgaagaagcc ggcatgtctc gtgacgccaa aacagtgctt 124561 tacgacggac gtactggaga gccgtttgat aaccgtgtat ctgtcggtat catgtacatg 124621 atcaaactgg ctcacatggt tgacgataaa cttcatgcac gctctacagg cccttactca 124681 cttgttacgc agcagcctct tggcggtaaa gcgcaatttg gcggacagcg ttttggtgag 124741 atggaggttt gggcacttga agcttacggt gcggcttaca ctcttcaaga aattctgact 124801 gttaagtctg atgacgtggt tggacgtgtg aaaacatacg aagccatcgt taaaggcgac 124861 aatgttcctg aaccaggtgt tccggaatca ttcaaagtat taatcaaaga acttcaaagc 124921 ttaggtatgg atgtcaaaat cctttctggt gatgaagaag aaatagaaat gagagattta 124981 gaagacgaag aagatgcgaa acaagctgac ggcctggcat tatcaggtga tgaagagccg 125041 gaagaaacag catctgcaga cgttgaacgc gatgtagtaa caaaagaata atctctagtt 125101 ataaaggcaa gtgacatcgg ttaatccgaa gataaaaagg gaggtaggcc ccttgctaga 125161 tgtgaacaat tttgagtata tgaacatcgg tcttgcttca ccagataaaa tccgttcatg 125221 gtcttttggt gaagtgaaaa agcctgaaac gataaactat cgtacgttaa aacctgaaaa 125281 ggacggtcta ttctgcgaac gcattttcgg accgactaag gactgggaat gtcattgcgg 125341 gaagtacaag cgagttcgtt ataaaggcgt agtttgtgac cgctgcggag tcgaagtaac 125401 acgggctaaa gtccgtcgtg agagaatggg gcacattgaa ctggctgccc cagtttccca 125461 catttggtat ttcaaaggta ttccaagccg tatgggtctt gtgctggata tgtcacctcg 125521 tgctttagaa gaagtcattt actttgcttc ttacgttgta actgatccgg cgaatacacc 125581 gcttgaaaag aaacagcttc tgtctgagaa agaataccgt gcttatcttg ataaatacgg 125641 taataaattc caagcatcta tgggtgctga agcaattcat aaacttcttc aagatatcga 125701 tcttgtaaaa gaagttgata tgttaaaaga agagctgaaa acttcacaag gacaacgccg 125761 tactcgtgcg atcaaacgtc ttgaagtttt agaagccttc cgtaactcag gaaacaagcc 125821 ttcttggatg atccttgatg tgcttcctgt tattcctccg gagcttagac cgatggttca 125881 gctagatggc ggacgttttg cgacttctga tttgaatgac ctttatcgtc gtgtcatcaa 125941 ccgtaacaat cgtttgaaac gccttttgga ccttggtgcg cctagcatca tcgttcaaaa 126001 cgaaaagcgt atgcttcaag aggctgtcga tgccctaatt gacaacggcc gccgcggacg 126061 ccctgtaaca ggtcctggaa acagaccgtt aaaatctctt tctcacatgc tgaaagggaa 126121 gcaaggccgt ttccgtcaaa accttcttgg taaacgtgtc gattactccg gacgttctgt 126181 aatcgttgtt ggtcctcatt tgaaaatgta ccaatgcgga ttaccgaagg aaatggcact 126241 tgaacttttc aaacctttcg ttatgaaaga acttgttgaa aaaggtcttg ctcacaacat 126301 taagagtgcg aaacgcaaaa ttgagcgcgt acagcctgaa gtttgggatg tactagaatc 126361 agttattaag gagcatccgg tactgctgaa ccgtgcccct acacttcaca gattaggtat 126421 ccaggcgttt gaaccaacgc ttgttgaagg acgcgcaatc cgtcttcacc cgctcgtatg 126481 tacagcttac aacgctgact ttgacggtga ccaaatggcg gttcacgtac cattatctgc 126541 tgaagcacaa gctgaagcac gcatcttgat gcttgctgct caaaacatct tgaaccctaa 126601 agatggtaaa ccggttgtaa caccgtctca ggatatggta ctaggtaact attacctgac 126661 acttgagcgt gccggtgctg tcggtgaagg tatggtcttc aagaatacag acgaagcgct 126721 tcttgcttat caaaacggat atgttcacct tcatacgaga gtagctgttg cagctaactc 126781 acttaagaat gtgacattta ccgaagaaca gcgctcaaaa ttgttaatta caactgtcgg 126841 taagcttgtc ttcaatgaaa ttcttccgga atcattccct tacatgaatg aaccaacgaa 126901 gagcaacatt gaagagaaaa cacctgaccg tttcttctta gaaaaaggtg ctgatgttaa 126961 agctgttatc gcacagcagc caatcaatgc gccgtttaaa aaaggcattc tgggtaaaat 127021 catcgcggaa atctttaaac gattccatat tacggaaacg tctaaaatgc ttgaccgcat 127081 gaaaaaccta ggtttcaaat attcaactaa agctggtatt acagttgggg tttctgacat 127141 cgtcgtactc gatgataaac aagaaattct tgaggaagcg caaagcaaag ttgacaacgt 127201 tatgaagcaa ttccgccgcg gtcttatcac tgaagaagaa cgctatgaga gagtcatctc 127261 tatctggagt gctgcaaaag acgttatcca aggcaaactg atgaaatcac ttgatgaact 127321 caacccgatc tacatgatga gtgactctgg tgcccgtggt aacgcatcta actttacgca 127381 gcttgccgga atgcgcggcc tgatggccaa cccggctgga cgtatcattg agttgccgat 127441 caaatcaagt ttccgtgaag gtctgacagt attggagtac tttatctcca cacacggtgc 127501 gcgtaaaggt cttgccgata ccgctcttaa aactgctgac tcaggttacc ttacacgccg 127561 tctcgttgac gttgctcagg atgttatcat ccgtgaaact gattgcggaa ctgaccgagg 127621 cattcttgct aagcctctta aagaaggaac tgaaacaatt gagcgcttag aagaacgctt 127681 aatcggacgt tttgcaagaa aacaagtgaa gcaccctgaa acaggtgaag tgcttgtgaa 127741 tgaaaacgaa ctgatcgatg aagataaagc actggagatt gtcgaagccg gcattgaaga 127801 agtgtggatc cgttctgcct tcacatgtaa tacgcctcat ggtgtatgta aacgatgcta 127861 tggccgaaat cttgcaactg gctccgatgt tgaagtcggt gaagctgtcg gaatcattgc 127921 tgcccaatca atcggtgagc ctggtacaca gttaacaatg cgtacattcc atacaggcgg 127981 ggttgccgga gacgatatca cacagggtct tccgcgtatc caagagcttt tcgaagcgcg 128041 taatccgaaa ggtcaggcaa caattacaga aatcgacggt acagtcgttg agatcaatga 128101 agttcgtgat aagcaacagg aaattgtggt tcaaggcgca gtggaaacac gttcttatac 128161 ggcaccttac aactcccgcc tgaaagtagc ggaaggagat aaaattactc gaggccaagt 128221 actgacagaa ggttcaatcg atccgaaaga acttcttaaa gtgactgacc tgacgactgt 128281 tcaagagtat cttctccatg aggttcaaaa ggtttaccgt atgcagggtg ttgaaatcgg 128341 tgataaacac gtagaagtaa tggttcgcca gatgcttcgc aaagtacgcg tgattgatgc 128401 cggtgacact gatgtgcttc caggtacatt gcttgatatt caccaattta ctgaagcgaa 128461 caaaaaggta ttgcttgaag gcaaccgacc agctacaggc cgtcctgtct tactcggtat 128521 tacaaaagca tctcttgaaa ctgattcatt cttatctgct gcttccttcc aggaaacaac 128581 acgtgtcctt acagatgcag cgatcaaagg taagcgtgac gagcttctcg gcttgaaaga 128641 gaatgttatc atcggtaagc ttgttccagc aggtacagga atgatgaaat accgtaaagt 128701 aaaaccagta tcaaatgttc agccgactga cgatatggtc ccggttgaat aactgattta 128761 actctgctga aagactgcaa aaacagtctt tcagcagata tatttatgaa aaagtcactc 128821 tatgagaaga acgaatctaa aaaatgtcat accttgttga cattcgtctc ctagaatgat 128881 aatataacca aggtgctcga aataaacctg ttactttgga ggatatgttt atgtcttatg 128941 ataaagtatc acaggccaaa tcaattatta ttggtacgaa gcaaacagtg aaagctctaa 129001 agcgaggttc agtaaaggaa gtagtcgttg caaaagacgc agatccgata ctcacgtcaa 129061 gtgttgtttc acttgctgaa gatcaaggta tctctgtctc aatggttgaa tccatgaaaa 129121 agctcggcaa agcctgcgga attgaggtag gagcagccgc tgttgccatt attttataac 129181 gtacttttgt ttttgcgtaa gattccatct tgtgtaaaga cattgttttt tgccttttga 129241 tgaaccacct gggtatgtgg gttataaaac gtaatgaagg gaggaaaaat tcatgcctac 129301 aattaatcag ctaattcgca aaggacgcgt gagtaaagta gaaaactcaa agtctcctgc 129361 acttaacaaa ggatacaaca gctttaaaaa agagcacact aacgtatctt ctccacaaaa 129421 acgcggggta tgtactcgtg ttggtacaat gacaccgaaa aaaccgaact cagcacttcg 129481 taaatatgct cgtgttcgtt tgactaacgg aatcgaggtt actgcttaca ttcctggtat 129541 cggtcacaac ctgcaagagc acagtgttgt acttatccgc ggcggacgtg taaaagactt 129601 accaggggta cgttaccaca tcgttcgtgg tgcgcttgat actgctggag ttgaaaaccg 129661 tgcacaaggc cgttctaaat acggtacgaa aaaacctaaa gcaaaataat atacgaaaat 129721 acgcataatt gatgaaggga ggatattcag atgccacgta aaggtcctgt agcaaaaaga 129781 gatgttttac ctgatccgat ttacaactct aagcttgtat ctcgtttaat caacaaaatg 129841 atgatcgatg gtaaaaaagg taagtctcaa acgatcctat acaagtcatt cgatatcatt 129901 aaagaacgta ctggcaatga tgcaatggag gttttcgaac aagcattgaa aaacatcatg 129961 cctgtacttg aagtaaaagc acgccgtgta ggtggtgcga actaccaagt tcctgtagaa 130021 gttcgtcctg aacgtcgtac gactcttgga cttcgctggt tagttaacta cgctcgtctt 130081 cgtggagaaa aaacgatgga agagcgttta gctaacgaaa tccttgacgc agctaacaac 130141 actggtgctg ctgttaagaa acgtgaagac actcataaga tggctgaagc aaacaaagca 130201 tttgctcact atcgctggta ggatttatag attaacaaaa cacaatttcc taataaggaa 130261 ggagaaatta cccaatggca agagagttct ccttagaaaa aactcgtaat atcggtatca 130321 tggctcacat cgatgccggt aaaacgacta ctacagaacg tatcttgttc tatactggtc 130381 gtatccacaa aattggtgaa actcatgaag gagcttcaca aatggactgg atggagcagg 130441 aacaagaacg tggtatcaca atcacttccg ctgcgactac tgcacagtgg aaaggatacc 130501 gcgtaaacat catcgatact ccaggacacg tagacttcac agttgaagtt gaacgttctc 130561 ttcgtgtact tgatggtgct gttgctgtac ttgacgcgca atcaggcgtt gagcctcaaa 130621 cagaaactgt ttggcgtcag gcaacaactt atggagtacc gcgtatcgtt tttgttaaca 130681 aaatggacaa aatcggtgca gacttccttt actctgtagg aactttaaga gaccgtcttc 130741 aagcaaacgc tcatgcaatt caattgccga tcggtgctga agataacttc gaaggtatca 130801 ttgaccttgt agaaaacgtt gcgtatttct acgaagatga cctcggaact cgttctgatg 130861 caaaagaaat ccctgaagag tacaaagagc aagctgaaga gcttcgcaac agccttattg 130921 aagctgtatg tgagcttgat gaagagctta tggataagta ccttgagggt gaagaaatca 130981 caattgacga gttaaaagca ggaattcgta aaggtacatt aaatgttgaa ttctaccctg 131041 ttcttgttgg ttctgccttc aaaaacaaag gtgttcaact agtacttgat gctgttcttg 131101 actaccttcc tgcaccaact gacgttgctg caatcaaagg tacacgtcct gatacaaatg 131161 aagagattga gcgtcattct tctgacgaag agccattctc tgcattagca tttaaagtta 131221 tgactgaccc ttacgttggt aagttgacgt tcttccgtgt gtactctgga acacttgatt 131281 ctggttcata cgtgaaaaac tctactaaag gcaaacgtga gcgtgttgga cgtattcttc 131341 aaatgcacgc taacagccgt gaagaaatct ctactgtata cgcaggggat atcgcagctg 131401 ctgtaggtct aaaagataca actactggag atactctatg tgatgagaag gatcttgtta 131461 tccttgagtc aatggaattc ccagaaccag ttatcgacgt tgctattgag cctaaatcaa 131521 aagctgacca agataaaatg ggtatcgctt tagcgaaact tgctgaagaa gatcctacat 131581 tccgtactca aacaaaccca gaaactggcc aaacgatcat ctctggtatg ggtgaacttc 131641 accttgatat cattgttgac cgtatgaaac gcgaatttaa agtagaagcc aatgttggtg 131701 ctcctcaagt tgcgtaccgt gaaacattcc gtaccggtgc aaaagttgaa ggtaaattcg 131761 tacgtcagtc tggtggacgc ggtcagttcg gacacgtttg gatcgaattc gaaccaaacg 131821 aagaaggcgc tggctttgaa tttgaaaatg cgattgtcgg tggggtcgtt cctcgtgaat 131881 acatcccagc tgttcaagca ggtctggaag atgcactcga aaatggtgta ctagcaggct 131941 tcccgcttat cgacattaaa gctaaacttt tcgacggttc ttaccatgat gttgactcaa 132001 acgaaatggc atttaaagtc gctgcttcta tggcattgaa aaatgcagtc agcaaatgta 132061 acccagttct tcttgaacca atcatgaaag tggaagtggt tattccagaa gaatatatgg 132121 gagatatcat gggtgatatc acttcacgtc gcggacgcgt agaaggtatg gaagcacgcg 132181 gtaacgctca agttgttcgt gctatggttc ctcttgctga aatgttcggt tacgctactg 132241 cacttcgttc taatacgcaa ggtcgcggta cgttcactat gcacatggat cactacgaag 132301 aagtgccgaa gagcgtcgca gaagaaatta tcaaaaaaaa taaaggcgaa taattgattt 132361 tgccgcttaa ctcaagtata actactattg taagatgagg aagtgaaagc tttctttcac 132421 ttcctatcac tctatacatt actaattaaa agctcttaag gaggatttta gaatggctaa 132481 agaaaaattc gaccgttcca aatcacatgc caatattggt acaattggac acgttgacca 132541 tggtaaaaca actttaactg ctgctatcac aacagtactt cataagaaat ctggtaaagg 132601 tacagctatg gcgtacgatc aaattgatgg tgctccagaa gaacgcgagc gcggtatcac 132661 aatctctact gcacacgttg agtacgaaac tgaaactcgt cactatgcac acgttgactg 132721 cccaggacac gctgactatg ttaaaaacat gatcactggt gctgcgcaaa tggacggagc 132781 tatccttgta gtatctgctg ctgatggccc aatgccacaa actcgtgagc acatccttct 132841 ttctaaaaac gttggtgtac catacatcgt tgtattctta aacaaatgcg acatggtaga 132901 cgacgaagag cttcttgaac tagttgaaat ggaagttcgc gatcttctta gcgaatacga 132961 cttccctggt gatgatgtac cagttgttaa aggttctgct cttaaagctc ttgaaggaga 133021 cgctgagtgg gaagctaaaa tcttcgaact tatggatgcg gttgatgagt acatcccaac 133081 tccagaacgc gacactgaaa aaccattcat gatgccagtt gaggacgtat tctcaatcac 133141 tggtcgtggt acagttgcta ctggccgtgt agaacgcgga caagttaaag tcggtgacga 133201 agttgaaatc atcggtcttc aagaagagaa caagaaaaca actgttacag gtgttgaaat 133261 gttccgtaag cttcttgatt acgctgaagc tggtgacaac attggtgccc ttcttcgcgg 133321 tgtatctcgt gaagaaatcc aacgtggtca agtacttgct aaaccaggta caatcactcc 133381 acacagcaaa ttcaaagctg aagtttacgt tctttctaaa gaagagggtg gacgtcatac 133441 tccattcttc tctaactacc gtcctcagtt ctacttccgt acaactgacg taactggtat 133501 catccatctt ccagaaggcg tagaaatggt tatgcctgga gataacactg aaatgaacgt 133561 tgaacttatt tctacaatcg ctatcgaaga aggaactcgt ttctctattc gtgaaggcgg 133621 acgtactgtt ggttcaggcg ttgtttctac aatcactgag taatagtatg gttttaaacg 133681 agacccctgt gggtctcgtt ttttgtttgc ttatcttttt cttgtataat aggatctatc 133741 atattcgagg ggttaatatt tatgattcct gaaaagaaat caatcgcaat catgaaagaa 133801 ctaagcattg gaaatacaaa gcaaatgctg atgattaatg gagttgacgt gaaaaatcca 133861 ttgctgcttt ttttacatgg cgggccggga acgccgcaaa tcggatatgt tagacattat 133921 caaaaagagc tggaacagta ttttacagta gttcattggg atcagagagg atcggggctt 133981 tcttattcta agcgaatttc gcatcactct atgacaataa atcacttcat taaagataca 134041 atccaagtca ctcaatggct tttagctcat ttttcaaaat caaaacttta cctagccggt 134101 cattcttggg gatcaatact ggcgcttcat gtgctgcagc agcgtcctga tttattttac 134161 acgtattatg gaatcagcca ggttgttaac ccgcaagatg aagaatcaac tgcttatcaa 134221 catattcgtg aaatttccga atcaaaaaaa gccagcatat tatctttcct tacacgtttc 134281 attggtgctc cgccttggaa gcaggatatc cagcacctta tctatcggtt ttgtgttgag 134341 ctaaccaggg gaggattcac tcaccgtcat cgtcaatctc tcgctgtatt atttcaaatg 134401 cttactggca atgagtatgg agtgcggaac atgcacagct tccttaatgg attgcgcttc 134461 agtaaaaaac atttaactga tgagttgtac cggtttaatg cttttacatc agttccttct 134521 attaaagtac cgtgtgtttt catttcaggg aaacatgact taattgttcc tgcagaaata 134581 tcgaaacagt attatcaaga acttgaggca cctgaaaagc gctggtttca atttgagaat 134641 tcagctcaca ccccgcatat tgaggagcca tcattattcg cgaacacatt aagtcggcat 134701 gcacgacacc atttatgata gatccttgat aaataagaaa aacccctgta taataaaaaa 134761 agtgtgcaaa tcatgcatat tttaaataag tcttgcaaca tgcgcctatt ttctgtataa 134821 tggtgtatgt tggtctttga ctgcgatgaa gtgagaggtt gctgacacac ccggccgctt 134881 tgccatggca aggtgttcag gtttttctca cggagaactg tctaacgtga tgtaggcgaa 134941 aaggagggaa aataatggca aaacaaaaaa ttcgtattcg tttgaaagca tatgatcata 135001 gaatccttga tcaatctgca gagaagattg ttgaaacggc aaaacgttct ggtgccagcg 135061 tatctggtcc gattccgttg ccaactgaaa aatcagttta cacaatcctt cgtgcggtgc 135121 acaaatacaa agattctcgt gagcaatttg aaatgcgtac acataaacgt ttaatcgaca 135181 ttgtgaaccc aacaccacaa actgttgatg ctcttatgcg attagactta ccatctggtg 135241 tcgatatcga aattaaactt taattctaaa atatagaatg atcttaatag gaggtgtgac 135301 gaatgaccaa aggaatctta ggaagaaaaa ttggtatgac gcaagtattc gctgagaatg 135361 gtgatcttat tccggtaact gttatcgagg ctgctccaaa cgttgttctt caaaagaaaa 135421 cagctgaaaa cgacggttac gaagcaatcc agcttggttt tgacgacaag cgtgaaaagc 135481 tttctaacaa acctgaaaaa gggcacgttg caaaagcgga aactgctcct aagcgcttcg 135541 ttaaagaatt acgcggagtg gaaatggatg cgtatgaagt tggtcaggaa gtcaaggttg 135601 aaattttctc tgctggagaa atcgtagatg taacaggagt atctaaaggt aaaggtttcc 135661 aaggtgcgat caagcgccac ggacaatctc gcggacctat gtctcacggt tcacgctacc 135721 accgtcgtcc tggttcaatg ggacctgtag atcctaaccg tgtattcaaa ggtaaattat 135781 tacctggacg tatgggcgga gagcaaatca ctgttcaaaa ccttgaaatc gtaaaagttg 135841 atgcagaacg caatcttctt ttgatcaaag gtaacgtacc tggtgcgaag aaatctttaa 135901 tcactgttaa aagtgctgtt aaatctaaat aattctctta ggaaaggagg aaattgatta 135961 tgccaaaagt agcattatac aaccaaaacg gttctactgc tggtgacatc gaattaaacg 136021 cttctgtatt tggtatcgaa ccaaatgaga gtgttgtatt cgacgctatt cttatgcaaa 136081 gagcttcctt acgtcaagga actcacaaag taaaaaatcg ttctgaagta cgcggcggag 136141 gtcgtaaacc atggcgtcaa aaaggtactg gacgtgcccg tcaaggttca atccgttcac 136201 cgcaatggcg cggaggtggt gtcgtattcg gcccaacacc acgcagctat tcttataaat 136261 tacctaaaaa agttcgccgc ttggcaatca aatcagtatt gtcttctaaa gtgatcgaca 136321 acaacatcat cgttcttgaa gatcttactc ttgatacggc taaaacaaaa gaaatggcag 136381 ctatccttaa aggattatct gttgagaaaa aagctttaat cgtaactgcg gatgcaaacg 136441 aagcagtagc attatctgct cgtaacattc ctggagttac tgttgttgaa gctaacggaa 136501 tcaacgtttt agacgttgtc aaccacgaga agcttctgat tacaaaagca gcggttgaaa 136561 aagtagagga ggtgcttgca taatgaaaga tcctcgtgat gttctaaagc gccccgtcat 136621 tactgaacgt tctgccgatt taatgactga aaaaaaatat acttttgaag ttgatgtaag 136681 agctaacaaa acagaagtga aagacgcggt tgaaagcatc tttggagtga aagttgacaa 136741 agtcaacatc atgaactaca aaggcaaatc aaaacgtgtt ggacgctaca ctggtatgac 136801 tagccgtcgc agaaaagcga tcgtaaaact tactgcagac agcaaagaaa tcgaaatttt 136861 tgaagcttaa ttatctgtaa aaagaaggag ggaaattcaa aatggcgatt aaaaagtata 136921 aaccgacctc taatggacgt cgtggcatga caacttcaga ttttgctgaa atcacgactg 136981 acaagccgga aaaatccttg cttgctcccc ttcacaaaaa aggcggacgt aacaaccaag 137041 gtaaattgac tgtacgtcac caaggtggcg gacataaacg ccaataccgt gttatcgact 137101 tcaaacgcga taaagatggt atacctggac gcgttgctac agttgaatac gatccaaacc 137161 gttcagctaa catcgctcta atcaactatg cagacggaga aaaacgttac attcttgctc 137221 ctaaaggaat tcaagtaggt actgaaatca tgtcaggtcc tgaagctgac attaaagtag 137281 gtaatgcact tccacttatc aacatccctg ttggtacagt tgtgcataac attgaattaa 137341 aacctggtaa aggcggacag cttgtacgtt cagctggtac atctgctcag gttcttggta 137401 aagaaggtaa atacgttctt gtacgtctta actctggtga agttcgcatg atcctttctg 137461 cttgccgtgc ttctatcggt caagtaggta acgaacagca cgaacttatc aacattggta 137521 aagctggacg ttctcgctgg aaaggcatcc gtcctacagt tcgtggttct gtaatgaacc 137581 ctaacgatca cccacacggt ggtggtgaag gacgtgcgcc aatcggacgt aaatcaccaa 137641 tgtctccatg gggcaaacca actcttggat tcaagactcg taagaaaaag aacaaatccg 137701 ataaatttat cgtacgtcgt cgtaaaaata aataacgggg ttgtctacgg ttcttttcgg 137761 accgtagtgc aatcacgaag ggaggttcca aaatggctcg cagcttaaaa aaaggaccat 137821 ttgtcgatgg acacttgatg actaaaatcg agaaattaaa tgaaacagac aagaaacaag 137881 tcgtaaaaac ttggtctcgt cgttctacta ttttcccaca gtttattggt cacacaatcg 137941 cagtctatga cggacgtaaa cacgtgcctg tattcatctc tgaagatatg gtagggcaca 138001 agttgggtga attcgctcca actcgtacgt acaaaggtca tgctagtgat gacaaaaaaa 138061 caagacgcta agagaggagg cttttaaatg caagctaaag ctgttgcaag aacagtccgt 138121 attgctcctc gtaaagcacg tctagtaatg gacctgattc gaggcaagca agtaggtgag 138181 gcagtatcaa tcttgaacct tacaccaaga gctgcttctc caattatcga gaaagtatta 138241 aaatccgcta ttgcaaatgc tgagcataac tatgaaatgg acgctaacaa cctggttatt 138301 tctcaagcat tcgttgacga aggccctacg ttaaaaagat tccgcccacg tgctatggga 138361 cgtgcgagcc aaatcaacaa acgtacgagc cacattacaa tcgttgtatc agaaaagaag 138421 gagggataag tagtgggtca aaaggtaaat ccagtcggtc ttcgtatcgg agtcattcgt 138481 gattgggaat ctaagtggta cgctggtaaa gattacgctg acttcctgca cgaagattta 138541 aaaattcgtg aatacattag caaacgcctt tctgacgctt ctgtttctaa agtagaaatt 138601 gagcgtgcag caaaccgcgt taacattacg atccacacag ctaagcctgg tatggttatc 138661 ggtaaaggcg gttctgaagt cgaagcactt cgcaaagccc ttaacagcct tactggcaag 138721 cgtgtacaca ttaacattct tgaaatcaaa agagcagatc ttgatgcaca gctagttgct 138781 gacaacatcg ctcgtcaatt agaaaaccgt gtttctttcc gccgtgcgca gaaacaacaa 138841 atccaacgta ctatgcgtgc tggagcacaa ggtgtgaaaa caatggtttc tggtcgtctt 138901 ggcggtgcag atatcgctcg ttctgaatac tacagtgaag gaactgttcc attgcacaca 138961 ttacgtgcgg acattgacta tgcaacatct gaagctgata ctacttacgg taagcttggt 139021 gtaaaagtct ggatctatcg tggagaggtt cttcctacta agaagaaaaa tgaggaagga 139081 ggaaaataat atgttattac caaaacgcgt taaatatcgc agagagcatc gcggaaaaat 139141 gcgtggccgt gcgaaaggcg gtactgaagt acatttcgga gaattcggta tccaagctct 139201 agaagcttct tggattacta accgtcaaat cgaagctgca cgtattgcga tgactcgtta 139261 catgaaacgt ggcggtaaag tttggatcaa aattttccct tctaaacctt acactgctaa 139321 accacttgag gtacgtatgg gatccggtaa aggggctcca gaaggttggg tagctgttgt 139381 aaaaccgggc aaagttttat ttgaaatttc tggtgtgtct gaagaggttg ctcgtgaagc 139441 gcttcgcctt gcatctcaca aattgccaat taaaacgaag ttcgtaaaac gtgaagaaat 139501 tggtggtgaa tcaaatgaaa gctaatgaaa ttcgtgacct taccactgct gaaattgaac 139561 aaaaagtaaa gtctcttaaa gaagaacttt tcaatcttcg ctttcaatta gcgacaggac 139621 aacttgaaaa tactgctcgc attcgtgaag tgcgcaaagc tatcgcgcgc atgaaaactg 139681 tgattcgtga aagagaaatt gctgctaata aataatcact gaggggaggt cgtgagcatg 139741 agcgaacgta accaacgcaa agtttaccaa ggccgtgttg tttctgacaa aatggataaa 139801 accattactg ttgttgttga gacatacaaa aaacatacac tttacggtaa acgcgtaaaa 139861 tactcaaaaa aattcaaagc acatgatgaa aataatcaag ctaaaatcgg tgacatcgtt 139921 aagatcatgg aaactcgtcc attgtctgca actaagcgtt tccgtctagt tgaagttgtc 139981 gaagaagctg ttattatcta ataaagttcg gaattctttt tccgaaggga ggtaacaaat 140041 aatgattcaa caagagactc gtttaaaagt agctgacaac tctggcgcac gtgaagtact 140101 tactattaaa gttcttggtg gttctggacg taaaacagct aacattggtg atgtaattgt 140161 ttgcacggtt aaacaagcaa caccaggagg cgttgtcaaa aaaggtgaag tcgtaaaagc 140221 tgttatcgtt cgcactaaaa gcggagcgcg cagaagtgac ggttcataca tcagcttcga 140281 tgagaatgca tgtgttatca tccgtgacga caagagccca cgcggaactc gtatcttcgg 140341 accagttgct cgtgaattgc gtgaaaacaa ctttatgaaa attgtttctc tagctccaga 140401 agttatctaa ttgaaataaa tgccttactc aaggaggtgc gatcaggatg catgtaaaaa 140461 aaggcgataa agttatggtt atctctggta aagataaagg caaacaagga acaatccttg 140521 ctgctttccc taaaaaggac cgcgttttag ttgaaggtgt taacatggta aagaaacact 140581 ctaaaccaac tcaagctaac cctcaaggcg gtatttctaa tcaagaggcg ccaattcatg 140641 tatcaaacgt tatgccgctc gatcctaaaa caggtgaagt gactcgcgta ggatacaaag 140701 tggaagatgg caaaaaagtt cgtgtagcaa aaaaatctgg gcaagttcta gataaatagt 140761 attaaaagga agggaggtct atctcatgaa ccgccttaaa gaaaagtaca ataaagaaat 140821 tgcacctgct ttaatgacta agttcaacta tgattcagtc atgcaagtgc ctaaaatcga 140881 aaaaatcgta atcaacatgg gtgttggtga cgctgttcaa aacgccaaag caatcgacag 140941 tgctgttgag gaattaacgt ttatcgcagg tcaaaaacct gtcgttactc gtgcgaagaa 141001 atcaattgct ggattccgtc ttcgtgaggg aatgcctatc ggtgcgaaag taactcttcg 141061 cggagagcgc atgtatgatt tccttgataa acttatttct gtatctttac cgcgtgtacg 141121 tgacttccgc ggggtttcta aaaaatcttt cgacggtcgc ggtaactaca cacttggtat 141181 caaagaacag ttaatcttcc ctgaaattga ctacgataaa gtaacaaagg ttcgcggaat 141241 ggacatcgtt atcgtaacaa ctgctaatac tgacgaagaa gctcgtgagc tattaactca 141301 agtaggtatg ccgttccaga aataatcaat gaaagggagg cgaaatcgtg gctaaaaagt 141361 ctatgattgc gaaacaacaa cgtacaccaa agtttaaagt acaagagtac acacgctgtg 141421 aacgctgcgg acgtccgcat tcagtcattc gtaaatttaa actttgccgt atttgtttcc 141481 gtgagcttgc atataaagga caaattcctg gcgtgaaaaa agccagctgg taatccccaa 141541 gaaagggaag gaggtaatta tataatggtt atgacagatc caattgcaga tatgctaact 141601 cgtattcgca atgcaaacat ggtacgtcat gagaagcttg aaattcctgc ttctaaattg 141661 aaaagagaaa ttgctgaaat tttaaagcgt gaaggtttca ttcgtgacgt tgagttcgta 141721 gaagacagca aacaaggtat tatccgcgtt ttcttgaaat acggacaaaa caacgagcgc 141781 gttatcactg gtcttaaaag aatcagcaag cctggtttgc gtgtttatgc taaatctaat 141841 gaagtacccc gcgtacttaa cggtcttgga atcgcgatta tttctacatc acaaggtgtt 141901 ttaacggaca aagaagcccg tgcaaaacaa gctggtggag aagttctagc atacgtttgg 141961 taagaagttt aacatgaatg gaggtgtttg gtatgtctcg tgtaggtaag aagctacttg 142021 agattccttc tgatgttaca gtaacgttaa atgataacaa cactgtagct gtgaaaggac 142081 caaaaggaga attaactcgt acgtttcacc ctgatatgga gattaaagta gaggacaatg 142141 tgcttacagt cgctcgtcct tctgatcaaa aagagcaccg tgccctgcat ggtacgactc 142201 gcagtctgct tggcaacatg gttgaaggtg tatctaaagg atttgaaaga ggtttggaat 142261 tagtcggtgt cggttaccgt gcttctaaat ccggaaataa acttgtttta aacgttggat 142321 actctcatcc tgttgagatc gttcctgaag aaggcatcga aatcgaagtt ccttctcaaa 142381 caaaagtagt tgtaaaaggt acagacaaag aacgcgtagg agctattgct gctaacatcc 142441 gcgctgtacg ttctccagag ccttacaaag gtaaaggaat ccgctacgaa ggtgaagttg 142501 ttcgccgtaa agaaggtaaa tctgctaagt aagatcgctt aaagtgaaga aaggagtgac 142561 ctagatgatt acgaaaacta gcaaaaatgc tgctcgtctt aaaagacacg ctcgtgttcg 142621 cgctaaactt tccggtactg ctgaaagacc gcgcctgaac gttttccgtt ctaacaagca 142681 catttacgct caaatcatcg atgatgtaaa tggtgtaaca cttgctagtg catctactct 142741 cgataaagac ttgaacgttg aaagcactgg agatacttct gctgctacta aagttggaga 142801 attagttgca aaacgcgctg ctgaaaaagg catttctgac gtagtatttg accgtggcgg 142861 atacttatac catggacgtg taaaagcttt ggctgatgcc gctcgtgaag ctggacttaa 142921 attttaataa aagaaggagg gacacatgat tatgcgtcgt attgacccaa gcaaattaga 142981 gttagaagaa cgcttagtta cggttaaccg cgtagcgaaa gttgttaaag gtggtcgtcg 143041 tttccgcttc gcagctctag tcgttgtcgg tgacaaaaac ggacacgtag gattcggtac 143101 tggtaaagca caagaagtac cagaagcgat tcgcaaagct gttgaagatg cgaaaaagaa 143161 tttgattgaa gtaccaatgg ttggaactac aattccacac gaaatcatcg gacgtttcgg 143221 tgcaggtaac atcttgttaa aacctgcttc tgaaggtact ggagttatcg ctggaggccc 143281 tgtacgtgcg gtacttgagc tagctggtgt agctgatatc ctttctaagt ctttaggttc 143341 taacacaccg atcaacatga ttcgtgcaac acttcaaggt ttaagtgaac ttaaacgtgc 143401 tgaagacgtt gcgaagcttc gtggaaaatc tgtagaagaa ctgttaggat aaggagggaa 143461 cattaatggc taaattagaa attaccctca aacgaagtgt aatcggtcgc ccggaagacc 143521 aacgcgttac tgtaagaaca cttggtttaa agaaaacaaa ccaaactgtt gttcatgaag 143581 acaacgctgc gatccgtggt atgattaata aagtatctca tttagtttct gttaaagaac 143641 aataaaaata tttgatcgga taaggaggtg tcctaatgaa acttcatgaa ttaaaacctt 143701 cagaaggttc acgcaaaacg cgtaatcgcg taggtcgtgg tattggttct ggcaacggta 143761 aaacagctgg taaaggtcac aaaggtcaaa acgctcgttc tggcggcggt gtacgccctg 143821 gattcgaggg gggacaaatg cctttattcc aacgtcttcc taaacgtggt ttcactaaca 143881 tcaaccgcaa ggaatacgct gtagtcaacc tagacaaatt gaacggtttt gcagaaggaa 143941 cggaagtcac tcctgaactt cttctagaga ctggtgttat tagcaaactt aatgcaggag 144001 taaagattct tggcaacggt aaattagaga aaaaattaac tgtaaaagcc aataaattct 144061 ctgcttctgc gaaagaagct gttgaagctg ctggcggtac agctgaggtg atctaacttg 144121 tttaaaacaa tctccaactt tatgcgtgtg agtgatatca ggaataaaat catattcact 144181 ttactcatgc ttatcgtctt tcgcataggt gcgtttattc ctgtgcctta cgttaacgct 144241 gaagcgttac aggcacagtc tcaaatgggt gtttttgatc tccttaatac atttggcggc 144301 ggtgcgcttt accaattttc cattttcgca atgggaatta ctccttatat cacggcttcg 144361 atcatcattc agctgcttca gatggatgtg gtaccgaagt ttaccgagtg gtctaagcaa 144421 ggtgaagttg gccgccgtaa attagctcag ttcacaaggt actttacgat tgtgcttggt 144481 ttcatccaag cgttaggtat gtcatatgga ttcaacaatc tggcaaacgg tatgctgatc 144541 gaaaaatccg gtgtatcgac atatcttatc attgctttag tgctcactgg cggaactgcc 144601 tttttaatgt ggcttgggga acaaattact tctcatggag taggcaacgg aatatcgatc 144661 attatcttcg cggggattgt gtctagtatt ccaaaaacaa ttgggcaaat atatgagact 144721 caatttgtcg gcagcaacga tcagttgttt attcatattg tgaaagtcgc acttcttgtg 144781 attgcgattt tagcagttat tgttggagtt attttcattc agcaagccgt acggaaaatt 144841 gcgattcaat atgctaaagg cacaggtcgt tcacctgctg gcggaggtca gtctacacac 144901 cttccattga aagtgaatcc tgcaggggtt attccggtaa tctttgcggt tgcgtttttg 144961 ataacgccgc ggacgatcgc gtcattcttt ggaacaaacg atgtgacaaa gtggattcaa 145021 aacaactttg ataatacgca tccggtgggt atggcgatat atgttgcgtt gattattgcc 145081 tttacgtact tttatgcttt tgtacaggta aaccctgaac aaatggctga taaccttaaa 145141 aaacagggtg gctatatccc gggggttcgt ccagggaaaa tgactcaaga tagaattacg 145201 agcattttgt atcgacttac gtttgtgggt tctatattct tagccgtgat ttccattctt 145261 cctatctttt tcattcaatt cgctggattg cctcaaagtg cacaaattgg cggaacatct 145321 ttgttaattg ttgtcggggt agccttggag acaatgaaac aactagaaag ccagttggtg 145381 aaacgaaact accgtggatt tatgaaaaac tagaggaaat ggatttatcc attccctctt 145441 aataaagaga ggacggggga aatccgaatg aacttagtct taatggggct tcctggtgcc 145501 ggtaaaggca cacagggcga acgaattgtt gaggattatg ggattcctca tatctcaaca 145561 ggagatatgt tccgtgctgc tatgaaagaa gaaacaccac tcggactcga agcaaaatct 145621 tatattgata agggagagct cgtacctgac gaagtcacaa tcggaattgt aaaagagaga 145681 cttggcaaag atgattgtga aagaggtttt cttctggacg gatttccgcg aacagtcgct 145741 caagccgaag ctcttgaaga aattcttgag gaatacggca agccgattga ttatgtcatt 145801 aacattgaag tcgacaaaga tgttctgatg gaacgtctga ctggacgcag aatttgcagt 145861 gtttgcggca caacctatca tttagtcttt aatccgccga aaacgccggg tatttgtgat 145921 aaagacggag gcgaactcta tcaacgggca gatgataatg aggaaacagt ctctaaacgg 145981 cttgaggtaa acatgaagca aactcagcct ttactcgatt tctattcaga gaaaggttat 146041 cttgcaaacg tgaatggcca gcaggacatt caagacgttt atgcagatgt gaaggatctt 146101 cttggaggat taaaaaaatg attatctgta aaaccccacg tgaacttggt atcatgcggg 146161 aagcagggcg aatcgtggct ttaactcatg aagagttaaa aaagcacatt aaaccaggaa 146221 tctcgacaaa agaattggat caaattgccg aacgttttat taagaagcag ggtgcaatcc 146281 catcttttaa ggggtataat gggtttcgcg ggagcatttg cgtatcagtt aatgaagaac 146341 tcgttcacgg catacctggc agcagggtgc tgaaggacgg tgacatcatc agtattgata 146401 tcggtgctaa attaaatggt tatcatggtg actctgcatg gacatatccg gtaggaaaca 146461 tcagcgatga tgacaaaaaa cttctggaag tgacagagga gtctttatat aaaggcttgc 146521 aggaagcaaa accaggtgaa cgtttgtcga atatttccca cgcaatacaa acgtatgtcg 146581 aaaatgagca gttttcagtt gttagggagt atgtcggaca tggtgttggt caagacttgc 146641 atgaggaccc gcaaattcct cattacggtc cgcccaacaa aggaccacgg cttaaacctg 146701 gcatggttct cgctattgaa cctatggtga acgctggcag ccgctacgtg aaaacattgg 146761 ctgataactg gacggttgta acggtagatg ggaaaaagtg tgctcatttt gaacatacga 146821 ttgcgattac ggaaacgggt tttgatatac tgacgagagt ctagatgatg aaaataattc 146881 cgaagacaga tgtttttcaa gcttgatagg gcagaaagct tgggtgaaca ttggcaagac 146941 cgaattcatc ttgcttcttg tcgttggaat tttaaccatc atcaatgtac taacagcaga 147001 cggagaaaag cgtacatttc attctcctaa gaaaaagaat atcaatcatt taacccttta 147061 tgattgcgta tctccggaag ttcagaacag tataaacgaa acagggcgtg tgacaaactt 147121 cttttgaaat ttgtcagaaa gcaagttact gatttgaaga agggagaaca cttgaatggc 147181 gaaagacgat gtaattgaag tggaaggtac tatagtcgaa acactgccaa acgcgatgtt 147241 caaagttgaa cttgaaaatg gccacactgt tttggctcat gtatctggta aaatccgcat 147301 gcacttcatt cgcattttac ctggagacaa agttacggta gaattatctc catatgactt 147361 aactcgtggc aggattacgt accgttacaa ataaagcact ccggaaactg aaggaggttg 147421 gaaacacatg aaagtgagac catcagttaa accaatctgc gaaaaatgta aagttattcg 147481 cagaaaagga aaagtaatgg tgatctgtga aaatccaaag cataaacaaa aacaaggata 147541 atttataagg aggtgcccag agaatggctc gtattgctgg tgtagatatc ccacgtgaca 147601 aacgtgttgt tatttcttta acatacatct tcggaattgg ccgcacaacg gctcagcaag 147661 ttttaaaaga agctggagtt tcagaagata ctcgtgtgcg cgatcttact gaagaagaac 147721 ttggtaaaat ccgtgatatt attgacaaac tgaaagtaga aggtgacctt cgccgtgaag 147781 tttctcttaa tatcaaacgt ctgatcgaaa tcggaagcta ccgcggaatc cgtcatcgca 147841 gaggattacc tgttcgcgga caaaactcta aaaacaacgc gcgtactcgt aaaggtccgc 147901 gtcgtactgt agctaacaag aaaaaataag taagggaggt tcttaaacaa tggctgctgc 147961 tcgtaaatct aacacgcgta aacgtcgcgt gaaaaagaat attgagtctg gaattgctca 148021 tattcgttca actttcaata acacgatcgt tacgatcact gacactcatg gtaatgctat 148081 ttcttggtct agtgccggag ctttaggatt cagaggttct cgtaaatcta ctccttttgc 148141 tgcgcaaatg gctgcagaaa cagctgctaa aggttcaatc gaacatggtc ttaaaactct 148201 agaggttact gttaaaggac ctggttcagg ccgtgaagct gcaatccgtg cacttcaagc 148261 tgctggacta gaagtcactg ctatcagaga cgtaactcct gttcctcata acggatgccg 148321 tccaccaaaa cgtcgccgcg tgtaatttgt ttgtatagat tttgtgtccc tgtcaataat 148381 gggttatgat acagttattt atgaaacgaa tgcaccgact cgttgcctga gcacatacgg 148441 gactaaacaa tggggaattt cggatggaat ctcatatgat tctattcgag gtttcgacgt 148501 tttgaaggag ggttttaagt aatgatcgag attgaaaaac caaaaatcga aacggttgaa 148561 atcagcgacg atgccaaatt tggtaagttt gtcgtagagc cacttgagcg tggatatggt 148621 acaactctgg gtaactcctt acgtcgtatc ctcttatcct cactccctgg tgccgctgta 148681 acatcaatcc agatagatgg tgtactgcac gaattctcga caattgaagg cgttgtggaa 148741 gatgttacaa cgattatctt acacattaaa aagcttgcat tgaaaatcta ctctgatgaa 148801 gagaagacgc tagaaattga tgtacagggt gaaggaactg taacggcagc tgatattaca 148861 cacgatagtg atgtagagat cttaaatcct gatcttcata tcgcgactct tggtgagaat 148921 gcgagtttcc gagttcgcct tactgctcaa agaggacgtg ggtatacgcc tgctgacgca 148981 aacaagagag acgatcagcc aatcggcgtg attccgatcg attctatcta tacgccagtt 149041 tctcgtgtat cttatcaggt agagaacact cgtgtaggcc aagttgcaaa ctatgataaa 149101 cttacacttg atgtttggac tgatggaagc actggaccga aagaagcaat tgcgcttggt 149161 tcaaagattt taactgaaca ccttaatata ttcgttggtt taactgacga agctcaacat 149221 gctgaaatca tggttgaaaa agaagaagat caaaaagaga aagttcttga aatgacaatt 149281 gaagaattgg atctttctgt tcgttcttac aactgcttaa agcgtgcggg tattaacacg 149341 gttcaagagc ttgcgaacaa gacggaagaa gatatgatga aagttcgaaa tctaggacgc 149401 aaatcacttg aagaagtgaa agcgaaacta gaagaacttg gactcggact tcgcaaagac 149461 gattgactag tttcccttgt gaactaggat tttcgtgtgt ttattattca gaaacagcat 149521 tccaataaag gaggggacat cacatgtcat acagaaaact aggacgtacg agtgcacagc 149581 gtaaagctat gcttcgtgat cttacaactg atttgatcat caacgaaaga atcgaaacaa 149641 ctgaaacacg tgcgaaagaa cttcgctctg tagttgaaaa aatgatcacg cttggcaaac 149701 gcggtgatct tcacgctcgc cgtcaagctg ctgcatacat ccgcaacgag gttgcaaacg 149761 aagaaaataa tcaagatgca cttcaaaaat tattctctga cattgcaact cgttacgagg 149821 agcgccaagg tggatacaca cgtattatga agcttggtcc tcgccgtggt gacggagcac 149881 caatggcaat tatcgaattg gtttaatcac atatttttgt gtatctaaag aagggcggga 149941 cagtttctaa ctggatctat gccctttttt tagatactgc aacttttaat agagagaaaa 150001 gcagagcatt agctgagagg aggccggttt tccatgaatc aaaatcagtt gatatcggta 150061 gaggatatcg tatttcgata tcggaaggac gcagaaagac gagcactaga cggcgtctcc 150121 ctgcaggtgt atgagggtga atggcttgca atcgtaggtc ataacggttc agggaaatca 150181 acactggccc gggcattgaa tggtttaatt cttcctgaat caggcgacat tgaggttgcc 150241 gggattcaat tgacagagga atctgtttgg gaagtgcgta agaagatagg tatggtcttt 150301 caaaatccgg ataaccaatt tgtcggaacg actgttcgcg atgatgtggc ttttggttta 150361 gaaaacaatg gtgtaccgcg ggaagaaatg attgagagag tagactgggc agtaaaacag 150421 gtgaatatgc aagattttct cgatcaagag ccgcaccatc tctccggagg ccaaaagcag 150481 agagttgcga ttgcgggggt tattgccgca cgtcctgata ttattatctt agatgaagca 150541 acatccatgc ttgatccgat cgggcgagaa gaagtgcttg aaacggtaag acatttaaaa 150601 gagcagggca tggcgactgt catatccatt acacatgacc tgaatgaggc agcaaaagca 150661 gacaggatca ttgtcatgaa tggcggtaaa aaatatgctg aagggccgcc tgaagagatt 150721 tttaaattga ataaagaact tgttcgaatt gggcttgatt tacccttctc attccagctt 150781 agccagcttt taagagaaaa tggactggct ttggaagaaa accatttgac tcaggaaggg 150841 ctggtgaaag agctgtggac attacaatca aagatgtaga gcatcgctat cagatgaaga 150901 ccccgtttga gcgcctagca ctgtatgata tcaatgcatc gattaaagaa ggaagctacg 150961 tagccgttat cgggcataca ggctctggca agtccactct tctacagcac ctaaatggtc 151021 tcctgaagcc gacgaaggga cagatatcac taggcagcac tgtcattcag gcagggaaaa 151081 agaataaaga tctgaaaaaa cttcgtaaaa aagtcggaat cgttttccaa tttcctgagc 151141 atcaattatt cgaagaaaca gttcttaaag atatttcatt cggaccgatg aactttggtg 151201 ttaaaaaaga agatgctgaa caaaaagcga gagagatgct gcagcttgta ggtttatcag 151261 aagagctttt ggacaggtca ccctttgaat taagcggggg acaaatgcgc agagttgcaa 151321 ttgccggcgt acttgcaatg gaccctgaag tgcttgttct ggatgaaccg actgcaggat 151381 tggacccaag agggcgaaaa gagattatgg acatgtttta tgagcttcat caacgtggga 151441 acttgacgac gatccttgtg acacacagca tggaggatgc agctgcatac gctgatgaaa 151501 tgattgttat gcataaagga acgatacaag catcaggcag tccgcgtgat ctgtttttaa 151561 agggtgaaga gatggccggc tgggggctgg atcttcctga aacaataaaa ttccaaagac 151621 accttgaagc tgcactgggt gtgagattta atgagcctat gctcacaatc gaagatgccg 151681 ctgccgaaat ccgtgctctt tttcagggag agaagacttt atgatggaca gcatgattat 151741 cggcaagtat gtaccgggga cttcacttgt gcaccggctt gaccccagaa caaaactgat 151801 cacgatcttt ttatttgtct gcattgtatt cttagccaat aatgttcaga catatgcgtt 151861 gcttggttta tttacaattg gcgtcgtttc tttaacaaga gttcctttct cttttttaat 151921 gaaagggctg aagccaatca tctggattgt cctttttacg ttccttcttc acattcttat 151981 gacacatgaa ggaccgatta tctttcaaat aggttttttc aaagtctatg agggcggtct 152041 ggttcagggg atattcattt ctcttagatt cgtctatttg attttaatca caaccttatt 152101 aacgcttacg actacaccga ttgagattac cgatggaatg gagcagctgc tgaacccatt 152161 gaaaaaatta aagcttcctg ttcatgagct ggctcttatg atgtcaattt ctttacggtt 152221 tattccgaca ctgatggagg agacagataa gatcatgaag gctcagatgg cgcgaggcgt 152281 tgattttaca agcgggcctg tcaaagaaag agtgaaggct attgtcccgc ttcttgtccc 152341 gctcttcgtc agcgcattta aacgcgccga agagcttgcg gtggcaatgg aagcaagagg 152401 ctatcaaggc ggagaaggac gtacgaaata tagaaagctt gtatggacag gaaaagacac 152461 ttctgtcatt gtcagcttaa ttgtattagc tgctttgtta tttttcttaa gggcttagag 152521 gtgctgtatg agactgaaat gcacgatttc ttatgacgga catttgttta acggttatca 152581 ggttcagccg ggcaaaagaa cggttcagga tgaactggag aaggctttgg ctgtcctgca 152641 taagtcaaaa gacagaattc cggtcgtttc gtctggaaga acagacagcg gggttcacgc 152701 agccggacag gtgattcatt ttgacactcc gctgtctatc ccggctgaga gatggccata 152761 tgccttaaat gcactgcttc cggacgatat cgcagtcaaa caggcagaaa ttgcggatga 152821 tgggttccat gcacgattta gcgcagtcaa aaaagaatat cgctactttg tatacacgga 152881 gaaacacccg gacgtattta aacggcatta cgcttaccat ttttcatatc gccttaatgt 152941 gcaggacatg agagaagcgg caaagcatct tatagggaca catgatttta cgagcttttg 153001 cgcggctaaa acagaagtgc aggacaaggt aagaacgata tacgaacttg attggactga 153061 gacggctgac ggcctgcaaa tgcggatcac aggcagcggt ttcttatata atatggtcag 153121 aattattgcg ggtactttgc ttgatgcagg tattggaaaa atttctcccg atgaggtgaa 153181 atccatgctg gaagcgaagg atcgcgaagc ggcagggcgc acagcgccgg ggcacgggct 153241 atatttatgg aacgtttact atgacaacta aaccaggtgt ataatatttt cttgacagag 153301 tctgcataaa gttataagat atcatatggt atgtatttca accccacgat aagccccgga 153361 acttattgtg ttgtgaaata gaacgtaatc gaagtttatt gaaaatgaca gatcatttag 153421 gagggaaatt caatgcgtac aacacctatg gctaacgcaa gtactattga acgcaagtgg 153481 ttagttgttg atgctgctgg caagacttta ggtcgtcttt cttcagaagt tgcagctatc 153541 cttcgcggaa aacacaaacc aacttacaca ccacacgttg atactggaga tcatgtgatc 153601 atcatcaacg ctgaaaaaat cgagttaact ggtaaaaagt taactgacaa aatctactac 153661 cgtcacactc aacatccagg cggattaaaa tcaagaactg ctcttgaaat gcgtacaaac 153721 taccctgaga aaatgcttga gcttgctatc aaaggcatgc ttccaaaagg ttctctaggt 153781 cgtcaaatgt tcaaaaaatt gaacgtatac cgtggttctg agcatccaca cgaagcacaa 153841 aaacctgaag tttacgaact tcgcggttaa ttaaaaagga ggttaccaat ttggcacagg 153901 ttcaatatta cggtactggc cgtcgtaaaa gctctgtagc gcgtgtgcgt ttagttccag 153961 gagaaggccg tatcgtcgtt aataatcgtg aaatcagcga acatatccca tctgcagctt 154021 taatcgaaga tatcaaacaa ccattaactt tgactgaaac agctggcact tatgatgttt 154081 tagtaaacgt acatggaggc ggcctatctg gtcaagctgg agcaatccgt cacggtatcg 154141 ctcgtgcttt gcttgaagca gatccagaat accgtacaac tcttaaacgt gcaggtcttc 154201 tgactcgtga cgctcgtatg aaagaacgta aaaaatacgg tcttaaaggc gctcgtcgtg 154261 cacctcagtt ctcaaaacgt taattttacg ttttcaaaaa gctctcgacc ttgggttggg 154321 agcttttttc tttcaataaa acgtggcagt cccgcataaa aataacaact gaatggacgc 154381 ttgacggggt taagcaaatt gtttgtttat aaacggtctc tttgtaataa tcatggtaga 154441 tttcattctt attcaattgg aagttcggtc aatgtttatt atcgttatgt gatcagccca 154501 gctccatcta accactgtat ctcatccgtt aaagttcact gctgattctt aacccggaga 154561 aacaatagct ctcattgcta atggctttat gtaacgaagt aaaagtaaat ctgatgatat 154621 aaatcacata tctcctttgt gatttttttg cgtttttatg aacttttttc taaatatgca 154681 aagggaaagc gatatcaatc tagaaatatt tgttatactc tatacattaa agtaaggaga 154741 agattcatga atgcgttagt agctcataat agcaaagcct gggataaaaa agtagaaaca 154801 ggcaatgaat ggactgttgc tgttgaacag caggttatcg aacaagcaaa aaaaggcaat 154861 tgggatataa gggtaacacc aatgaaagat gtaccgaagg attggtttcc gcctatcaaa 154921 ggtctgaaag tactctgttt agcatcaggc ggcggccagc agggtccagt tttggcagcc 154981 gcaggcgcgg atgtcactgt attagataac tcagaaaaac agctgaatca ggatagaatg 155041 attgctgagc gagatggtct gacgatacac actgtcaaag gaagcatgga cgatttaagt 155101 gtatttaatg atgaatcatt tgatgtcatt gtacatcctg ttgccaatgt ttttgttgag 155161 aatgtcctcc cggtatggaa ggaagcgtac cgtgtgttga aaaggaacgg cattctaatc 155221 tcgggttttg tcaatcctgt tgtatttctg tttgatacag aattagaaca gcaaggtgtt 155281 ttaaaagtaa aacactctat tccatacgct gacccagaag atcttccgaa acataaagtg 155341 aaaaaactga tcgaaaataa tgaggctctg gaattcggcc attccttaga agaccaaatc 155401 aaaggccaaa ttgatgccgg ttttatcgtt actggttttt atgaagataa aggcggtttt 155461 gtattagacc aatatatcca tacatattct gcaacaagaa gcgtgaaagt atgaaaagca 155521 gcgacctgtt agaggggctg cttttttcat aaccaattac agaacatttg ttcctcaccc 155581 tgcagaaagc tgatttttta tcaatgttac accttcattt gggcgaattt ccaaccgaat 155641 tcgggcattg tttcatcatc caaacctcaa aataatcggt aaaaggagag tgaatttata 155701 tggcagaagt actgtctttt atggatgtga aacgccaaaa ggattttgaa ttagaaaaga 155761 acttgctcaa agaactctct ctgagacaaa ttatccagtc tgttaaggat tgtttggaac 155821 cattatttcc atttttacat gatgaacgag atattattac cgaaggctgt attgattttg 155881 cgattgaagc ttatttgtta ggcgggcgtt ttgggatatt cggctattac ggagaatcaa 155941 tgcagagtat cagtgcccgc tctgcaagag aagaagaaga gctgcgtatg gagttttttg 156001 attatctcta taattggata cacgagcaat acgcaacatt tgataaaaac actgtttatg 156061 aagcggcacg caagttcatt aaagattggt ggacagcagg gtttgttcaa agagaaaaac 156121 agtgtaagct tcgcatgcgg taatcatatt tcccgaccct gtcccatagt tatgtaataa 156181 cggacaagcg ggaggggaag ggatgaggaa aaagcttaaa tggctcagtt ttttgctagg 156241 cttcatcata ttactatttc tgttcaagta tcagttcagc aataacgact cttggaagcc 156301 gtggagcctg cccttgagcg gtaaaatcat ttatctagat ccaggtcatg gcgggcctga 156361 cggcggagca gtcggcggaa agctgttaga gaaggatgtt accctggaag tggcctttag 156421 agtcagggat tatcttcaag aacaaggagc gcttgttatc atgaccagag aaagtgatac 156481 tgatctcgct ccagaaggaa caaaaggcta tagccgacga aaagctgagg atctaagaca 156541 acgagtcaaa ttaataaacc attcagaggc ggagctctat atcagcattc atcttaatgc 156601 gattccgtca caaaaatgga gcggagccca aagcttttat tacgggaaat atgcggaaaa 156661 tgagaaagtc gcaaaataca ttcaggatga gctgagaaga aatctggaaa acacaacccg 156721 gaaagcaaag cggattcatg gtatctactt aatgcaaaac gtcaccaaac cgggggcgct 156781 tatagaagtc ggatttttat ccaatccaag tgaagcaacg ttgctcggta aaccgaaata 156841 tcaagacaag gtggcatctt ccatatataa aggcattttg cgatatttca cagaaaaagg 156901 agaccctccg gagtaatgga gggttttctt gtggttctaa gcataagaca cccgccattt 156961 atgtatgata taataataat tgtaaacgaa tacacaaaag ggtgaggttc gatgataaga 157021 gaagatgaag taagaaaact agtcggagaa atgcgcgaac cttttcttca aagacctctg 157081 ggagaattgg atgccgttaa ggaaattaaa ataaagcctg aaaaacggca tatcagtgta 157141 aaagtcgctc ttgcaaaaac aggaactgca gaacaaatgc agattcagca agagatcgta 157201 aacgtattaa aaggggcagg agctgagaca gtcggccttc gatttgaaga gctgcctgaa 157261 gaaacggttg ctaaattccg ggcgccgtca gctgagaaaa aaacattatt aaatatggat 157321 aacccgccag tctttcttgc tgtagcaagt ggaaaaggcg gcgtaggcaa gtcaactgtg 157381 tcagtaaacc tagctatttc tctggctcgt ctagggaaaa aggttggttt aattgatgcg 157441 gatatttatg ggttcagtgt gccggacatg atgggtatca ctgtgcgtcc aacaattgaa 157501 ggagagaaac ttcttcctgt tgaacgcttt ggagtaaagg tcatgtcaat gggctttttc 157561 gtagaagaaa atgccccggt cgtatggaga gggccgatgc tcggcaaaat gctgaataat 157621 tttttccatg aagtagagtg gggagaagta gactatatcg ttcttgatct tccgcctggt 157681 acaggggacg ttgctctcga tgtacataca atgcttccga gctgcaaaga aattatcgta 157741 tctacgccac atccgacagc tgcttttgtc gcggccagag cgggctctat ggcgattaaa 157801 accgatcatg aggtcgtggg tgtcatagag aacatggctt attatgaaag tgcaaagaca 157861 ggggaaagag aatatgtgtt tggaaaaggc ggaggagata aactggctga ggaactaaac 157921 gtgcctttgc tcggcagaat cccattgaaa cagcccgatt gggataagga ccaatttgct 157981 ccgtctgttt atgacgaaaa tcatccaatc ggagaaatat atcaggacat cgcaaaaaaa 158041 atagatgcaa aaatgtcagt gcaggtataa aaggtgaacc gggattccag atcccggctt 158101 tccctttatt cactttcttt tgctgtgtct tttgctgctt ttttcagctc atcttcgaac 158161 tgctttttgt aaagcggact agaaagtgtt tcgttaataa cctcttctaa ataactgcgg 158221 aattcttggc tttttgccag ctggctgtac tttttatcca tgccgggatc ctgcataacg 158281 ctcatcagca tcttctggta atctggatcc ttcatcagct ttttaatcac tttttcatgc 158341 tctgtctgaa gagttttggc aaagccctca gcaaaatcag tgtcttcaaa gatgtttttc 158401 caaaattctt cacctttttt agatgtgagt gttttttcta ttgttccttt aattgcatct 158461 tggtcaatca ccagcgcttc attcatggca tcatcattta ataattcctt aatagctttc 158521 tttccatcat cagtttttaa tatatcaaca accatttttt tggtctgatc atagtccata 158581 tccgctgctt ggtcttttgg agcgcaagct gttacagata ataacaaaaa acagctcatc 158641 aatagcgttt tggcttttga catgcttaag ctcctttcac atacttgtct tacctttaat 158701 atgattcatc tgtttggaat tatacataac aaaatatcgc tgttcgcgat ttttgagggg 158761 atgaataaag aaatgaaaag ccgtggttta gttcgttttt tcttttctat tttagctgtc 158821 ggggcgctta tcacgagtat tgtgggtttt gctttaaagt ggggagaata tagagggctg 158881 tttctaacat ttgaagcggg acagattttc tctgttttat tttggtttat cggtgtaggc 158941 atgattttca gtgtgatcag ccaaatgggt tttttcgtgt ttttaacagt tcatcggttt 159001 gcgcttgaga tattaaggtc ctcctctttg tggaatttgc tgcagttgtt tttcatcctg 159061 tttgttgctt ttgatttaat gtacgtgcgt tttttatttt ttggagagag cggagaatcg 159121 ctggctggct atgcgtggtt accggtgttt ttattgatct ttggagtgat tacagcttat 159181 ataaagcaaa agcagtcctc taagaaaaca tttgtgtcat cgttattttt gatggttgtg 159241 attaccgcat tagaatggtt ccctgcatta agagtaaatg atgaggactg gctttattta 159301 atgctttttc cgttaatggc atgtaatgcc ttccaattgc tgatgctgcc gaagtttgca 159361 gcaaagtaat tactttacct ctgcggattt ggcatcagaa tttgcgatga gatcacccac 159421 ggttacattt tttaatcctt tttctttcag ctgatggatg atatcaggca atgcttcttc 159481 tgtttgtttt gcagaatcgg aggcatgtaa aagaataatg tctccaccgg aaacttgctt 159541 ggtcacattg tcgatgattt tttcaactcc gggatttgtc cagtcttgag agttcacact 159601 gtaatgaacg actgtataat tgtattgctt tgcgaccttt agaacattct tattgaattg 159661 gccggtaggg ggtcttaata gctgtatgtc tttgacccct aacttttcaa aggctgtttg 159721 cgcacggttc atgtcctttt ttatttcgct gctctctaaa ttggcatagt ttttataagc 159781 gtagcccatg ctcccgattt gatggccgtc ctttacgata cgggccactg tgtcgggatg 159841 gcgttctgcc caagaagcgg acaggaaaaa cgttgcgttt ttaatcccgt ttgctttcag 159901 agtattaagt atcggttctg ctctctcatc accccagctg atatcgaaag taagtgaaat 159961 atctttagag tctgtttctc ctttataaat ggctttaggt ccggtgtcag ttgaaaacac 160021 gggaagcggg acagctcttt ggatataaaa aaagctggca gctgcaaatg cggcgataag 160081 tataataatt aattgtttta cccgtttaat gtgccacaca tagaagtgat tcactgatga 160141 tgcctcctta tcttgtccat cattcttgtt ttacatctta tgagcatgga caattgaata 160201 taaccgataa aatgtctctt cacatacagc ctaaattggg tgttgacctt ttgataatat 160261 ccgtgatata ttattattcg tcgctgataa acagctgaca tcaactaaaa gcttcattaa 160321 atactttgaa aaaagttgtt gacttaaaag aagctaaatg ttatagtaat aaagctgctt 160381 cgttaagcgg cagtaatgat ctttgaaaac taaacaagac aaaacgtacc tgttaattca 160441 tttttataaa tcgcacagcg atgtgcgtag tcagtcaaac tactttatcg gagagtttga 160501 tcctggctca ggacgaacgc tggcggcgtg cctaatacat gcaagtcgag cggacagatg 160561 ggagcttgct ccctgatgtt agcggcggac gggtgagtaa cacgtgggta acctgcctgt 160621 aagactggga taactccggg aaaccggggc taataccgga tggttgtttg aaccgcatgg 160681 ttcaaacata aaaggtggct tcggctacca cttacagatg gacccgcggc gcattagcta 160741 gttggtgagg taatggctca ccaaggcaac gatgcgtagc cgacctgaga gggtgatcgg 160801 ccacactggg actgagacac ggcccagact cctacgggag gcagcagtag ggaatcttcc 160861 gcaatggacg aaagtctgac ggagcaacgc cgcgtgagtg atgaaggttt tcggatcgta 160921 aagctctgtt gttagggaag aacaagtacc gttcgaatag ggcggtacct tgacggtacc 160981 taaccagaaa gccacggcta actacgtgcc agcagccgcg gtaatacgta ggtggcaagc 161041 gttgtccgga attattgggc gtaaagggct cgcaggcggt ttcttaagtc tgatgtgaaa 161101 gcccccggct caaccgggga gggtcattgg aaactgggga acttgagtgc agaagaggag 161161 agtggaattc cacgtgtagc ggtgaaatgc gtagagatgt ggaggaacac cagtggcgaa 161221 ggcgactctc tggtctgtaa ctgacgctga ggagcgaaag cgtggggagc gaacaggatt 161281 agataccctg gtagtccacg ccgtaaacga tgagtgctaa gtgttagggg gtttccgccc 161341 cttagtgctg cagctaacgc attaagcact ccgcctgggg agtacggtcg caagactgaa 161401 actcaaagga attgacgggg gcccgcacaa gcggtggagc atgtggttta attcgaagca 161461 acgcgaagaa ccttaccagg tcttgacatc ctctgacaat cctagagata ggacgtcccc 161521 ttcgggggca gagtgacagg tggtgcatgg ttgtcgtcag ctcgtgtcgt gagatgttgg 161581 gttaagtccc gcaacgagcg caacccttga tcttagttgc cagcattcag ttgggcactc 161641 taaggtgact gccggtgaca aaccggagga aggtggggat gacgtcaaat catcatgccc 161701 cttatgacct gggctacaca cgtgctacaa tggacagaac aaagggcagc gaaaccgcga 161761 ggttaagcca atcccacaaa tctgttctca gttcggatcg cagtctgcaa ctcgactgcg 161821 tgaagctgga atcgctagta atcgcggatc agcatgccgc ggtgaatacg ttcccgggcc 161881 ttgtacacac cgcccgtcac accacgagag tttgtaacac ccgaagtcgg tgaggtaacc 161941 ttttaggagc cagccgccga aggtgggaca gatgattggg gtgaagtcgt aacaaggtag 162001 ccgtatcgga aggtgcggct ggatcacctc ctttctaagg atattatacg gaatataaga 162061 ccttgggtct tataaacaga acgttccctg tcttgtttag ttttgaagga tcattccttc 162121 gaaacgtgtt ctttgaaaac tagataacag tagacatcac attcaagtaa tacaagatat 162181 cacatagtga ttctttttaa cggttaagtt agaaagggcg cacggtggat gccttggcac 162241 taggagccga tgaaggacgg gacgaacacc gatatgcttc ggggagctgt aagcaagctt 162301 tgatccggag atttccgaat ggggaaaccc accactcgta atggagtggt atccatatct 162361 gaattcatag gatatgagaa ggcagacccg gggaactgaa acatctaagt acccggagga 162421 agagaaagca aatgcgattc cctgagtagc ggcgagcgaa acgggattag cccaaaccaa 162481 gaggcttgcc tcttggggtt gtaggacact ctgtacggag ttacaaagga acgaggtaga 162541 tgaagaggtc tggaaaggcc cgccatagga ggtaacagcc ctgtagtcaa aacttcgttc 162601 tctcctgagt ggatcctgag tacggcggaa cacgtgaaat tccgtcggaa tccgggagga 162661 ccatctccca aggctaaata ctccctagtg accgatagtg aaccagtacc gtgagggaaa 162721 ggtgaaaagc accccggaag gggagtgaaa gagatcctga aaccgtgtgc ctacaagtag 162781 tcagagcccg ttaacgggtg atggcgtgcc ttttgtagaa tgaaccggcg agttacgatc 162841 tcgtgcaagg ttaagcagaa gatgcggagc cgcagcgaaa gcgagtctga atagggcgca 162901 tgagtacgtg gtcgtagacc cgaaaccagg tgatctaccc atgtccaggg tgaagttcag 162961 gtaacactga atggaggccc gaacccacgc acgttgaaaa gtgcggggat gaggtgtggg 163021 taggggtgaa atgccaatcg aacctggaga tagctggttc tctccgaaat agctttaggg 163081 ctagcctcaa ggtaagagtc ttggaggtag agcactgatt ggactagggg cccctaccgg 163141 gttaccgaat tcagtcaaac tccgaatgcc aatgacttat ccttgggagt cagactgcga 163201 gtgataagat ccgtagtcga aagggaaaca gcccagaccg ccagctaagg tcccaaagta 163261 tacgttaagt ggaaaaggat gtggagttgc ttagacaacc aggatgttgg cttagaagca 163321 gccaccattt aaagagtgcg taatagctca ctggtcgagt gactctgcgc cgaaaatgta 163381 ccggggctaa acgtatcacc gaagctgcgg actgttcttc gaacagtggt aggagagcgt 163441 tctaagggct gtgaagccag accggaagga ctggtggagc gcttagaagt gagaatgccg 163501 gtatgagtag cgaaagaggg gtgagaatcc cctccaccga atgcctaagg tttcctgagg 163561 aaggctcgtc cgctcagggt tagtcgggac ctaagccgag gccgaaaggc gtaggcgatg 163621 gacaacaggt tgatattcct gtaccacctc ctcaccattt gagcaatggg gggacgcagg 163681 aggatagggt aagcgcggta ttggatatcc gcgtccaagc agttaggctg ggaaataggc 163741 aaatccgttt cccataaggc tgagctgtga tggcgagcga aatatagtag cgaagttcct 163801 gattccacac tgccaagaaa agcctctagc gaggtgagag gtgcccgtac cgcaaaccga 163861 cacaggtagg cgaggagaga atcctaaggt gatcgagaga actctcgtta aggaactcgg 163921 caaaatgacc ccgtaacttc gggagaaggg gtgctctgtt agggtgcaag cccgagagag 163981 ccgcagtgaa taggcccagg cgactgttta gcaaaaacac aggtctctgc gaagccgtaa 164041 ggcgaagtat aggggctgac gcctgcccgg tgctggaagg ttaagaggag cgcttagcgt 164101 aagcgaaggt gcgaattgaa gccccagtaa acggcggccg taactataac ggtcctaagg 164161 tagcgaaatt ccttgtcggg taagttccga cccgcacgaa aggcgcaacg atctgggcac 164221 tgtctcaacg agagactcgg tgaaattata gtacctgtga agatgcaggt tacccgcgac 164281 aggacggaaa gaccccgtgg agctttactg cagcctgata ttgaatgttg gtacagcttg 164341 tacaggatag gtaggagcct tggaaaccgg agcgccagct tcggtggagg catcggtggg 164401 atactaccct ggctgtattg accttctaac ccgccgccct tatcgggcgg ggagacagtg 164461 tcaggtgggc agtttgactg gggcggtcgc ctcctaaaag gtaacggagg cgcccaaagg 164521 ttccctcaga atggttggaa atcattcgca gagtgtaaag gcacaaggga gcttgactgc 164581 gagacctaca agtcgagcag ggacgaaagt cgggcttagt gatccggtgg ttccgcatgg 164641 aagggccatc gctcaacgga taaaagctac cccggggata acaggcttat ctcccccaag 164701 agtccacatc gacggggagg tttggcacct cgatgtcggc tcatcgcatc ctggggctgt 164761 agtcggtccc aagggttggg ctgttcgccc attaaagcgg tacgcgagct gggttcagaa 164821 cgtcgtgaga cagttcggtc cctatccgtc gcgggcgcag gaaatttgag aggagctgtc 164881 cttagtacga gaggaccggg atggacgcac cgctggtgta ccagttgttc tgccaagggc 164941 atcgctgggt agctatgtgc ggacgggata agtgctgaaa gcatctaagc atgaagcccc 165001 cctcaagatg agatttccca ttccgcaagg aagtaagatc cctgaaagat gatcaggttg 165061 ataggtctga ggtggaagtg tggcgacaca tggagctgac agatactaat cgatcgagga 165121 cttaaccata tttttgaatg atgtcacatc tgttatctag ttttgagaga acactctcaa 165181 tttgtttggt ggcgatagcg aagaggtcac acccgttccc ataccgaaca cggaagttaa 165241 gctcttcagc gccgatggta gtcgggggtt tccccctgtg agagtaggac gccgccaagc 165301 agatttatta attctaccat gtttgtttat gaagctttat attattccgc agtagctcag 165361 tggtagagct atcggctgtt aaccgatcgg tcgtaggttc gaatcctacc tgcggagcca 165421 ttgcttccat agctcagcag gtagagcact tccatggtaa ggaagaggtc agcggttcga 165481 gcccgcttgg aagcttaaat gtattattac caaggtttct cataaggaga aagctttttt 165541 tattgcgata tgcggaagta gttcagtggt agaacaccac cttgccaagg tgggggtcgc 165601 gggttcgaat cccgtcttcc gctccattta tcctaacggg atattgtaaa ttgaattgcg 165661 cccgtagctc aattggatag agcgtttgac tacggatcaa aaggttaggg gttcgactcc 165721 tctcgggcgc gccatatctt ttaatagaat agataggaaa tcgggaagta gctcagcttg 165781 gtagagcaca tggtttggga ccatggggtc gcaggttcga atcctgtctt cccgaccatt 165841 ttttatgggg ccttagctca gctgggagag cgcctgcttt gcacgcagga ggtcagcggt 165901 tcgatcccgc taggctccac caaaagtttt taaaaaagtt attgactttg aagaagtgac 165961 attgtatact aataaagttg ctttaacaaa gcggacaaac aaaatgatct ttgaaaacta 166021 aacaagacaa aacgtacctg ttaattcagt ttttaaaaat cgcacagcga tgtgcgtagt 166081 cagtcaaact actttatcgg agagtttgat cctggctcag gacgaacgct ggcggcgtgc 166141 ctaatacatg caagtcgagc ggacagatgg gagcttgctc cctgatgtta gcggcggacg 166201 ggtgagtaac acgtgggtaa cctgcctgta agactgggat aactccggga aaccggggct 166261 aataccggat ggttgtttga accgcatggt tcaaacataa aaggtggctt cggctaccac 166321 ttacagatgg acccgcggcg cattagctag ttggtgaggt aacggctcac caaggcaacg 166381 atgcgtagcc gacctgagag ggtgatcggc cacactggga ctgagacacg gcccagactc 166441 ctacgggagg cagcagtagg gaatcttccg caatggacga aagtctgacg gagcaacgcc 166501 gcgtgagtga tgaaggtttt cggatcgtaa agctctgttg ttagggaaga acaagtaccg 166561 ttcgaatagg gcggtacctt gacggtacct aaccagaaag ccacggctaa ctacgtgcca 166621 gcagccgcgg taatacgtag gtggcaagcg ttgtccggaa ttattgggcg taaagggctc 166681 gcaggcggtt tcttaagtct gatgtgaaag cccccggctc aaccggggag ggtcattgga 166741 aactggggaa cttgagtgca gaagaggaga gtggaattcc acgtgtagcg gtgaaatgcg 166801 tagagatgtg gaggaacacc agtggcgaag gcgactctct ggtctgtaac tgacgctgag 166861 gagcgaaagc gtggggagcg aacaggatta gataccctgg tagtccacgc cgtaaacgat 166921 gagtgctaag tgttaggggg tttccgcccc ttagtgctgc agctaacgca ttaagcactc 166981 cgcctgggga gtacggtcgc aagactgaaa ctcaaaggaa ttgacggggg cccgcacaag 167041 cggtggagca tgtggtttaa ttcgaagcaa cgcgaagaac cttaccaggt cttgacatcc 167101 tctgacaatc ctagagatag gacgtcccct tcgggggcag agtgacaggt ggtgcatggt 167161 tgtcgtcagc tcgtgtcgtg agatgttggg ttaagtcccg caacgagcgc aacccttgat 167221 cttagttgcc agcattcagt tgggcactct aaggtgactg ccggtgacaa accggaggaa 167281 ggtggggatg acgtcaaatc atcatgcccc ttatgacctg ggctacacac gtgctacaat 167341 ggacagaaca aagggcagcg aaaccgcgag gttaagccaa tcccacaaat ctgttctcag 167401 ttcggatcgc agtctgcaac tcgactgcgt gaagctggaa tcgctagtaa tcgcggatca 167461 gcatgccgcg gtgaatacgt tcccgggcct tgtacacacc gcccgtcaca ccacgagagt 167521 ttgtaacacc cgaagtcggt gaggtaacct tttaggagcc agccgccgaa ggtgggacag 167581 atgattgggg tgaagtcgta acaaggtagc cgtatcggaa ggtgcggctg gatcacctcc 167641 tttctaagga tattatacgg aatataagac cttgggtctt ataaacagaa cgttccctgt 167701 cttgtttagt tttgaaggat cattccttcg aaacgtgttc tttgaaaact agataacagt 167761 agacatcaca ttcaagtaat acaagatatc acatagtgat tctttttaac ggttaagtta 167821 gaaagggcgc acggtggatg ccttggcact aggagccgat gaaggacggg acgaacaccg 167881 atatgcttcg gggagctgta agcaagcttt gatccggaga tttccgaatg gggaaaccca 167941 ccactcgtaa tggagtggta tccatatctg aattcatagg atatgagaag gcagacccgg 168001 ggaactgaaa catctaagta cccggaggaa gagaaagcaa atgcgattcc ctgagtagcg 168061 gcgagcgaaa cgggattagc ccaaaccaag aggcttgcct cttggggttg taggacactc 168121 tgtacggagt tacaaaggaa cgaggtagat gaagaggtct ggaaaggccc gccataggag 168181 gtaacagccc tgtagtcaaa acttcgttct ctcctgagtg gatcctgagt acggcggaac 168241 acgtgaaatt ccgtcggaat ccgggaggac catctcccaa ggctaaatac tccctagtga 168301 ccgatagtga accagtaccg tgagggaaag gtgaaaagca ccccggaagg ggagtgaaag 168361 agatcctgaa accgtgtgcc tacaagtagt cagagcccgt taacgggtga tggcgtgcct 168421 tttgtagaat gaaccggcga gttacgatct cgtgcaaggt taagcagaag atgcggagcc 168481 gcagcgaaag cgagtctgaa tagggcgcat gagtacgtgg tcgtagaccc gaaaccaggt 168541 gatctaccca tgtccagggt gaagttcagg taacactgaa tggaggcccg aacccacgca 168601 cgttgaaaag tgcggggatg aggtgtgggt aggggtgaaa tgccaatcga acctggagat 168661 agctggttct ctccgaaata gctttagggc tagcctcaag gtaagagtct tggaggtaga 168721 gcactgattg gactaggggc ccctaccggg ttaccgaatt cagtcaaact ccgaatgcca 168781 atgacttatc cttgggagtc agactgcgag tgataagatc cgtagtcgaa agggaaacag 168841 cccagaccgc cagctaaggt cccaaagtat acgttaagtg gaaaaggatg tggagttgct 168901 tagacaacca ggatgttggc ttagaagcag ccaccattta aagagtgcgt aatagctcac 168961 tggtcgagtg actctgcgcc gaaaatgtac cggggctaaa cgtatcaccg aagctgcgga 169021 ctgttcttcg aacagtggta ggagagcgtt ctaagggctg tgaagccaga ccggaaggac 169081 tggtggagcg cttagaagtg agaatgccgg tatgagtagc gaaagagggg tgagaatccc 169141 ctccaccgaa tgcctaaggt ttcctgagga aggctcgtcc gctcagggtt agtcgggacc 169201 taagccgagg ccgaaaggcg taggcgatgg acaacaggtt gatattcctg taccacctcc 169261 tcaccatttg agcaatgggg ggacgcagga ggatagggta agcgcggtat tggatatccg 169321 cgtccaagca gttaggctgg gaaataggca aatccgtttc ccataaggct gagctgtgat 169381 ggcgagcgaa atatagtagc gaagttcctg attccacact gccaagaaaa gcctctagcg 169441 aggtgagagg tgcccgtacc gcaaaccgac acaggtaggc gaggagagaa tcctaaggtg 169501 atcgagagaa ctctcgttaa ggaactcggc aaaatgaccc cgtaacttcg ggagaagggg 169561 tgctctgtta gggtgcaagc ccgagagagc cgcagtgaat aggcccaggc gactgtttag 169621 caaaaacaca ggtctctgcg aagccgtaag gcgaagtata ggggctgacg cctgcccggt 169681 gctggaaggt taagaggagc gcttagcgta agcgaaggtg cgaattgaag ccccagtaaa 169741 cggcggccgt aactataacg gtcctaaggt agcgaaattc cttgtcgggt aagttccgac 169801 ccgcacgaaa ggcgcaacga tctgggcact gtctcaacga gagactcggt gaaattatag 169861 tacctgtgaa gatgcaggtt acccgcgaca ggacggaaag accccgtgga gctttactgc 169921 agcctgatat tgaatgttgg tacagcttgt acaggatagg taggagcctt ggaaaccgga 169981 gcgccagctt cggtggaggc atcggtggga tactaccctg gctgtattga ccttctaacc 170041 cgccgccctt atcgggcggg gagacagtgt caggtgggca gtttgactgg ggcggtcgcc 170101 tcctaaaagg taacggaggc gcccaaaggt tccctcagaa tggttggaaa tcattcgcag 170161 agtgtaaagg cacaagggag cttgactgcg agacctacaa gtcgagcagg gacgaaagtc 170221 gggcttagtg atccggtggt tccgcatgga agggccatcg ctcaacggat aaaagctacc 170281 ccggggataa caggcttatc tcccccaaga gtccacatcg acggggaggt ttggcacctc 170341 gatgtcggct catcgcatcc tggggctgta gtcggtccca agggttgggc tgttcgccca 170401 ttaaagcggt acgcgagctg ggttcagaac gtcgtgagac agttcggtcc ctatccgtcg 170461 cgggcgcagg aaatttgaga ggagctgtcc ttagtacgag aggaccggga tggacgcacc 170521 gctggtgtac cagttgttct gccaagggca tcgctgggta gctatgtgcg gacgggataa 170581 gtgctgaaag catctaagca tgaagccccc ctcaagatga gatttcccat tccgcaagga 170641 agtaagatcc ctgaaagatg atcaggttga taggtctgag gtggaagtgt ggcgacacat 170701 ggagctgaca gatactaatc gatcgaggac ttaaccatat ttttgaatga tgtcacacct 170761 gttatctagt tttgagagaa cactctcaat ttgtttggtg gcgatagcga agaggtcaca 170821 cccgttccca taccgaacac ggaagttaag ctcttcagcg ccgatggtag tcgggggttt 170881 ccccctgtga gagtaggacg ccgccaagca attgcacatt agtgtaattt tttaaaaaag 170941 ttattgactt tgaagaagtg acattgtata ctaataaagt tgctttaaca aagcggacaa 171001 acaaaatgat ctttgaaaac taaacaagac aaaacgtacc tgttaattca gtttttaaaa 171061 atcgcacagc gatgtgcgta gtcagtcaaa ctactttatc ggagagtttg atcctggctc 171121 aggacgaacg ctggcggcgt gcctaataca tgcaagtcga gcggacagat gggagcttgc 171181 tccctgatgt tagcggcgga cgggtgagta acacgtgggt aacctgcctg taagactggg 171241 ataactccgg gaaaccgggg ctaataccgg atggttgttt gaaccgcatg gttcaaacat 171301 aaaaggtggc ttcggctacc acttacagat ggacccgcgg cgcattagct agttggtgag 171361 gtaacggctc accaaggcaa cgatgcgtag ccgacctgag agggtgatcg gccacactgg 171421 gactgagaca cggcccagac tcctacggga ggcagcagta gggaatcttc cgcaatggac 171481 gaaagtctga cggagcaacg ccgcgtgagt gatgaaggtt ttcggatcgt aaagctctgt 171541 tgttagggaa gaacaagtac cgttcgaata gggcggtacc ttgacggtac ctaaccagaa 171601 agccacggct aactacgtgc cagcagccgc ggtaatacgt aggtggcaag cgttgtccgg 171661 aattattggg cgtaaagggc tcgcaggcgg tttcttaagt ctgatgtgaa agcccccggc 171721 tcaaccgggg agggtcattg gaaactgggg aacttgagtg cagaagagga gagtggaatt 171781 ccacgtgtag cggtgaaatg cgtagagatg tggaggaaca ccagtggcga aggcgactct 171841 ctggtctgta actgacgctg aggagcgaaa gcgtggggag cgaacaggat tagataccct 171901 ggtagtccac gccgtaaacg atgagtgcta agtgttaggg ggtttccgcc ccttagtgct 171961 gcagctaacg cattaagcac tccgcctggg gagtacggtc gcaagactga aactcaaagg 172021 aattgacggg ggcccgcaca agcggtggag catgtggttt aattcgaagc aacgcgaaga 172081 accttaccag gtcttgacat cctctgacaa tcctagagat aggacgtccc cttcgggggc 172141 agagtgacag gtggtgcatg gttgtcgtca gctcgtgtcg tgagatgttg ggttaagtcc 172201 cgcaacgagc gcaacccttg atcttagttg ccagcattca gttgggcact ctaaggtgac 172261 tgccggtgac aaaccggagg aaggtgggga tgacgtcaaa tcatcatgcc ccttatgacc 172321 tgggctacac acgtgctaca atggacagaa caaagggcag cgaaaccgcg aggttaagcc 172381 aatcccacaa atctgttctc agttcggatc gcagtctgca actcgactgc gtgaagctgg 172441 aatcgctagt aatcgcggat cagcatgccg cggtgaatac gttcccgggc cttgtacaca 172501 ccgcccgtca caccacgaga gtttgtaaca cccgaagtcg gtgaggtaac cttttaggag 172561 ccagccgccg aaggtgggac agatgattgg ggtgaagtcg taacaaggta gccgtatcgg 172621 aaggtgcggc tggatcacct cctttctaag gatattatac ggaatataag accttgggtc 172681 ttataaacag aacgttccct gtcttgttta gttttgaagg atcattcctt cgaaacgtgt 172741 tctttgaaaa ctagataaca gtagacatca cattcaagta atacaagata tcacatagtg 172801 attcttttta acggttaagt tagaaagggc gcacggtgga tgccttggca ctaggagccg 172861 atgaaggacg ggacgaacac cgatatgctt cggggagctg taagcaagct ttgatccgga 172921 gatttccgaa tggggaaacc caccactcgt aatggagtgg tatccatatc tgaattcata 172981 ggatatgaga aggcagaccc ggggaactga aacatctaag tacccggagg aagagaaagc 173041 aaatgcgatt ccctgagtag cggcgagcga aacgggatta gcccaaacca agaggcttgc 173101 ctcttggggt tgtaggacac tctgtacgga gttacaaagg aacgaggtag atgaagaggt 173161 ctggaaaggc ccgccatagg aggtaacagc cctgtagtca aaacttcgtt ctctcctgag 173221 tggatcctga gtacggcgga acacgtgaaa ttccgtcgga atccgggagg accatctccc 173281 aaggctaaat actccctagt gaccgatagt gaaccagtac cgtgagggaa aggtgaaaag 173341 caccccggaa ggggagtgaa agagatcctg aaaccgtgtg cctacaagta gtcagagccc 173401 gttaacgggt gatggcgtgc cttttgtaga atgaaccggc gagttacgat ctcgtgcaag 173461 gttaagcaga agatgcggag ccgcagcgaa agcgagtctg aatagggcgc atgagtacgt 173521 ggtcgtagac ccgaaaccag gtgatctacc catgtccagg gtgaagttca ggtaacactg 173581 aatggaggcc cgaacccacg cacgttgaaa agtgcgggga tgaggtgtgg gtaggggtga 173641 aatgccaatc gaacctggag atagctggtt ctctccgaaa tagctttagg gctagcctca 173701 aggtaagagt cttggaggta gagcactgat tggactaggg gcccctaccg ggttaccgaa 173761 ttcagtcaaa ctccgaatgc caatgactta tccttgggag tcagactgcg agtgataaga 173821 tccgtagtcg aaagggaaac agcccagacc gccagctaag gtcccaaagt atacgttaag 173881 tggaaaagga tgtggagttg cttagacaac caggatgttg gcttagaagc agccaccatt 173941 taaagagtgc gtaatagctc actggtcgag tgactctgcg ccgaaaatgt accggggcta 174001 aacgtatcac cgaagctgcg gactgttctt cgaacagtgg taggagagcg ttctaagggc 174061 tgtgaagcca gaccggaagg actggtggag cgcttagaag tgagaatgcc ggtatgagta 174121 gcgaaagagg ggtgagaatc ccctccaccg aatgcctaag gtttcctgag gaaggctcgt 174181 ccgctcaggg ttagtcggga cctaagccga ggccgaaagg cgtaggcgat ggacaacagg 174241 ttgatattcc tgtaccacct cctcaccatt tgagcaatgg ggggacgcag gaggataggg 174301 taagcgcggt attggatatc cgcgtccaag cagttaggct gggaaatagg caaatccgtt 174361 tcccataagg ctgagctgtg atggcgagcg aaatatagta gcgaagttcc tgattccaca 174421 ctgccaagaa aagcctctag cgaggtgaga ggtgcccgta ccgcaaaccg acacaggtag 174481 gcgaggagag aatcctaagg tgatcgagag aactctcgtt aaggaactcg gcaaaatgac 174541 cccgtaactt cgggagaagg ggtgctctgt tagggtgcaa gcccgagaga gccgcagtga 174601 ataggcccag gcgactgttt agcaaaaaca caggtctctg cgaagccgta aggcgaagta 174661 taggggctga cgcctgcccg gtgctggaag gttaagagga gcgcttagcg taagcgaagg 174721 tgcgaattga agccccagta aacggcggcc gtaactataa cggtcctaag gtagcgaaat 174781 tccttgtcgg gtaagttccg acccgcacga aaggcgcaac gatctgggca ctgtctcaac 174841 gagagactcg gtgaaattat agtacctgtg aagatgcagg ttacccgcga caggacggaa 174901 agaccccgtg gagctttact gcagcctgat attgaatgtt ggtacagctt gtacaggata 174961 ggtaggagcc ttggaaaccg gagcgccagc ttcggtggag gcatcggtgg gatactaccc 175021 tggctgtatt gaccttctaa cccgccgccc ttatcgggcg gggagacagt gtcaggtggg 175081 cagtttgact ggggcggtcg cctcctaaaa ggtaacggag gcgcccaaag gttccctcag 175141 aatggttgga aatcattcgc agagtgtaaa ggcacaaggg agcttgactg cgagacctac 175201 aagtcgagca gggacgaaag tcgggcttag tgatccggtg gttccgcatg gaagggccat 175261 cgctcaacgg ataaaagcta ccccggggat aacaggctta tctcccccaa gagtccacat 175321 cgacggggag gtttggcacc tcgatgtcgg ctcatcgcat cctggggctg tagtcggtcc 175381 caagggttgg gctgttcgcc cattaaagcg gtacgcgagc tgggttcaga acgtcgtgag 175441 acagttcggt ccctatccgt cgcgggcgca ggaaatttga gaggagctgt ccttagtacg 175501 agaggaccgg gatggacgca ccgctggtgt accagttgtt ctgccaaggg catcgctggg 175561 tagctatgtg cggacgggat aagtgctgaa agcatctaag catgaagccc ccctcaagat 175621 gagatttccc attccgcaag gaagtaagat ccctgaaaga tgatcaggtt gataggtctg 175681 aggtggaagt gtggcgacac atggagctga cagatactaa tcgatcgagg acttaaccat 175741 atttttgaat gatgtcacac ctgttatcta gttttgagag aacactctca atttgtttgg 175801 tggcgatagc gaagaggtca cacccgttcc cataccgaac acggaagtta agctcttcag 175861 cgccgatggt agtcgggggt ttccccctgt gagagtagga cgccgccaag caagcttaaa 175921 cccagctcat tgagctgggt tttttgtttt atatctgtgc cgatttgctt tcgtcagtat 175981 ccattttatc aagcttctgc tttttaaagt tttctaatac ttttgaattc caatacaatc 176041 cctagcatga tcaacatgag agtcataaat aatcaaaatg cagtttgtac gggagactca 176101 tccagactcc atccgactgc gattggcagg atagagccgc caatccattg gcagcgaaca 176161 gcatgcttgt cgtttgttct gtttttccat gataaaattg attggtgaca ataaaataat 176221 ggcgaacatg ccggccataa ataagtccta agaaaaaact aagaataatc cctgcaaaag 176281 ctgttttatt gattgccaaa atacagagtt aaatgaggcc gctcatattt atcagcctga 176341 gataatgatg ataggttatt ttttcggaaa ccagctcggg ttgccaaatg agagaaaaga 176401 tattactgtc attaaaacga ttcttggttt catccggata tgataaaatg tctcagacta 176461 tatttgagcc atttttttct tcagcaatca tcttgcgtaa ttgataaaaa tttattatga 176521 tactctttgt atgacaactc cttgcctcaa tacaatatac tcaacgtttc cccgttttct 176581 ccggtcgttt ttcttttcat tttctcccgt aaaataaaaa aagctcccaa tacaatagat 176641 atggtgcgga tttatttttt actaaaaagg agtcgttata tttgaataat agttttacat 176701 taaaacagca atggttcggg aatatccgaa aagacattct tgctggcatt ttagttgcgt 176761 tagcgttaat acctgaagcg attggctttt ctattatagc cggtgtggat ccgatggtcg 176821 gtctttatgc gtcattttgc atagccatta ttatttctat ttttggtggc agacctggca 176881 tgatttcagc tgcgacaggc tcaatggcag tcgttatggt gtcgctggtt gctgatcatg 176941 ggcttcagta tttatttgcg gctacgattt tgacaggcat tattcaggtg attttaggta 177001 tcagtaaaat tgcaagatta atgaaattca tcccgcgttc tgtgatgatc gggtttgtga 177061 atgcgctggc gatccttatc ttctctgcgc agcttcccca gtttgaaggt gcttcttgga 177121 gcatgtatgc gatgcttgcc gggtcgttgg ttattattta tgtgctgcca aggtttacga 177181 ctgctgttcc gtctccgctt gtggcgatta ttgtgatgac aattattgcg gtcactttcc 177241 atgtggatgt gcggacggtt ggtgatatgg gcaatatttc tagttcattg cctcatttct 177301 taatccctga tgttccgttt acctttgaaa cactgcaaat tatttttcct tattcaattg 177361 ctttagcgtt tgtcgggttg cttgaatctt tgctgacagc acagattatt gatgaaatga 177421 cggatacgga tagtgataaa aataaagaga gccgcggaca gggaattgcg aatatcgtga 177481 ctggattctt tggcggaatg gcaggctgcg ctatgatcgg acaatctgtc attaatacaa 177541 aagcgggcgg tcgcggacgt ttgtcagcat ttgttgccgg tgcttttctg atgtttttaa 177601 ttgcggtgtt aagtcatgtc gtggtgaaaa tcccaatggc ggcgttagta gctgtaatgg 177661 ttatggtgtc tgtcggcact tttgattggt cttctttaaa aggtctcaaa aaagcgccgc 177721 tcacggactc gattgtcatg gttgtgactg tggttacggt tgttgtgacg gatgacttat 177781 ctaagggtgt atttgtcggt gttcttttaa gtgccgtgtt ctttgtagca aaaatctcga 177841 agctgaaaat cgtttctcat gcagaggatc aaaagcttag aacgtatcaa gtgaaggggc 177901 aaatcttttt tgcgtcagtg actgatctta cgaatgcgtt tatatatcaa gaggatattg 177961 agcgggttgt gattgactta actgaagctc acgtatggga cgattctggt gcggccgcac 178021 ttgataagat tgttgcgaag tttaaggaac aaggcattga agctgagtta aaaggtttga 178081 ataaagcgag taaatctcta atgaaacaga tggcataaaa tagagaagcc cagatgaatg 178141 agatctgggc ttttttatat aacatacact taagcagcat tgatataata gagagaagag 178201 aaattttaaa taggggactt gcatatgatg cttcagaagc tgaaccgtgt attggggaga 178261 gtgatgccgc tgttaacgcc gactagtgtg gtgctgggcg tgctgctgtc tcagttttta 178321 aatgggtatg aatgggctgt gccttggatc tttgctttta ttacgtttgc aggcagtttg 178381 agcgcgaact ttcaatcttt gagacatgca ttgtctcatc ctctccctat gattcttgca 178441 ctattcgttc ttcatatttt catgccgctt tttgcttggg gcagcggcca tcttatattt 178501 aaaggtgatc ctttgacgat taccggttta acattggctg ttgtgattcc tacggggatt 178561 acaagcttga tttgggcagc gatgtacaaa gggaatgtcg gtttgacact ttcgattatt 178621 ttagttgata ctgtgctgtc accgctaatc gtaccgctga gtctttcatt gctggccggc 178681 gctcaggttc acatggatgt gtggggaatg atgaaaggtc tgattgtaat ggtcgtgatt 178741 ccttcttttt tgggcatgct gtttaatcag atgtcatctc cagaaagaac tgcgtttgtg 178801 agcagtgcgc tgtcgccttt ttcaaagctt tgcttgatgg cagtgattgc gattaacagt 178861 tcagcgattg ctccttattt caaatccatt gatttgagat ttgcaggaat agctgtaacg 178921 gtattcttta tcgcgttaac aggttatgcc gctgcttggc tgatcggaaa aatgatgaaa 178981 aggcggcaag aggaaatagt ctctcttata tttacgggag gcatgaggaa tattagtgcc 179041 ggcgcagttc ttgccgttac gttcttcccg tctcaggttg ccgttcctgt tgtgatcggc 179101 atgctgtttc agcagatatt ggctgctttg tttggctata tgctgaatcg ttttgaatta 179161 aaaccaatgt tgcagaaggc ataaaaaaac cgctcatagg gttgagcggt tttttccgta 179221 tagccattcg agcgcgttga tgaactgttt gcagaaatac ttgtggtggt gcaccgctcc 179281 tttttcaatt gaaagacaca actggtcttc agtgaagcct ttttctttta gactttgatg 179341 aacttgcttt gtttttttca gcatatgtcg ctgaatggat tgtttttcac ggccttcttc 179401 actcccgata gacatgaaaa cacgtgcagt gccgggcttt aaagaagata tatgaatggt 179461 ttccgctgcg ttctcgtacc agtatgaacc tgatatagag cctattttcc cgaacattga 179521 cggatatttt aatatggcga acattgagat gaggccgcct aatgaggcac cgatcattcc 179581 tcttgactgc ggttccctgg tgacgttcca gttttcttcg attagcggaa tgaactggtt 179641 cgttatatca gacagatagt gatatcccat tccgccgaag tccgtgaacc gatcactgag 179701 tgatgcagcc ggccatgggg tgtattcatc aagccggttt tcgggttcga taccgatcag 179761 cacgagttca gggagccttt gctgttgaaa ggcgctttct agtaattcga tttggttttg 179821 gaacaaagaa ctgccatcct gcacgtaaac agcaggaaat cccccgctgt ctgtgctgta 179881 ggaaggaggg aggtacagcg tgaacctcct gttgccggct ttgtgttctg aaagagatcc 179941 tttcaagcat tctccccctt tttttgcttg aaaagcagat ataagaaata aggaactccg 180001 aggatcgcca aaatgatgcc tgcgggcact tctgcgggct gaaaaaacag ttttccggca 180061 aagtctgcgc ttatcacaag aagcatcccg attaaaccgc tcagtggcag gatatagcga 180121 tgttcgacgc cagccagtct ccgtgagata tggggagcaa ttaagccgac aaacgccata 180181 cttcccgcta cggagacaca ggcgctgatg attgctacac aggcaacgag aaggatggtt 180241 ttttctttat ttgatgaaat accgaggctt ctgactgtgt cttcatcaaa acgaatggtg 180301 tcgagcaggc gggatttgcc gataagaatc ggtataaaca gcagcatcca tgggagtaca 180361 gctgtaatat acgtccagtt ggcagaccag atgcttccgt ttttccacac catggccatt 180421 tgatagtctt gcgggtccat ttttaaagat aaaaacaaag acagggcgct gaatcctgaa 180481 ttgatcgcaa tccctaccaa aataattctt cctgaatcta aattgcctct gtgccatgca 180541 aatatgtaaa tcaggatcgc cgcgatgagc ccgcctatca atccaaagag cggcattccc 180601 atcgctgcag ctatggatgt cacttccttc tggccttgga ataagagcat aaacgctaca 180661 atgccagctc ctgcccctgc gttgattccg agaattccag ggtcagcaag cccgtttctc 180721 gtgatggcct ggataacagc gcctgcaatg ccaagaccga gtccaataat agcagccatg 180781 acaacccgcg gcagtcttaa atcgaacagc aaaatttcat actgcggatt cgggtcgatt 180841 tgaaaaagag tggagagcag ctcagcagga cgaacagaaa atgatccgct cgttaagctg 180901 aaatagctga caacaagaat caaagcgatg aacaatgcat attttttagc cattttgctc 180961 ccctcctttt cgtttaatta aataaaggaa gaaaggtacg ccgataatgg atgttacgac 181021 ctcaatcggt gtttcaaacg gatagttgat aaatctgctt gcgagatcac acagggttaa 181081 aaagattccg cccaaaatac aggaacacgg aatcagcctg ctgtaatcag agccgacgag 181141 aaatctcgtg atatgcggaa caaccaaccc gacaaacgca atttttccgg ccagcgctac 181201 ggcactgccg gttagaatga tgacggaaag catcgccatg attttaatgg tttttttctt 181261 ttgccccagg cttttagaaa tgtcgtcccc taatgataca gcggttacct ttttgctgag 181321 agaaatggcc attataatgc caatcaggaa aaacggagcg gcaagcttca ggaaatctgg 181381 actcatttga tgaagtctgg cactgtacca gaaactgaga tcctgagaaa tttgaaaata 181441 aatcgacatg gccgctgata agctgctgag cagcatgctt gtgactgtgc cgatgatggc 181501 gagctgcacg ggggtaaatc cgtttggcat catggcggca aggccgaata ctaacaccgc 181561 tcctaacgct gagccgataa aagagtatat catcatttca atcgaagatg attgcgggag 181621 cagaaccatg caaagcgtaa tgataaacgc tgaaccatct gaaacaccca taatggatgg 181681 cgaagctaaa taattgcgcg taatgccctg cataagcgct ccagaaacag caagggctgc 181741 ccctatgagc agagcgccgg cagcccttgg aatccgggaa tgccatataa tttgatggtc 181801 tgtgtttccc ggatcgaaat gaataagaga tgtaaaaaca atatctgtgc tgagatgctt 181861 tgccccataa aggattgaaa gcaaaagtga cagcgctata gcaaatggag aagtaatcaa 181921 tatgatacgt gtccactgtt ttgaatacat acaaaaacct actctgaatt agttttgtgt 181981 caatttttca gcagccgctt tcaggaaacg gactttgctc caagctgtgc cgccttgtgc 182041 gagagggtcc actgagttga catacacatg gtcttctttg actgctttaa ggcttttcca 182101 gattggattt ttctctaaat cttttaaggc atcaggtttg tctgcatttt catcatcaga 182161 aaattggacg aaaatatggt ccgggttcat ttcacttaat ttttctaatg aactcagctc 182221 ttgcgctttt gcagccttta cttcgttcgg cgccttaagg cctaaatcac cgtatagtgt 182281 ggagttgaaa tacacctgtt cagggtaaat gtaaatgttg ccttgtctga ttctgatgac 182341 aagcgctttt gaatctttcg ctttatcgtt gatttttgtt tttatttctt ttagatcctg 182401 ttcatagtct gcaataattt tctttgcttt tttctctttt ccagtcagct gggcaagaag 182461 catcatgttt tccttccagt ttgaagagat atgagaaact gggatcgtcg tgcctgctgt 182521 gctgattttt tgcagcgttt tttccggaaa ctttgttgaa gcaaggataa catctggctt 182581 catttcaaga atcttttcaa tatttggctc cattttttct ccggttggtt cggctttatc 182641 agtgatgtct ttgaacatat cagggaattt gccggagaat gaaattgcgc cttgcggatg 182701 aacgtcaagc aatttcgcgt cttccattga ttcaacgctt cccgtaatgg caattttgtc 182761 tgtcggtaca gttacttcat atgttttatc aaggtattca attttcttct tctcagatgc 182821 tgtgccgctt gccttgctgg cagttgattc atttttgctg ccgcaagctg ccgccgtcag 182881 cgcgagaagt aagattaata aggtaagaga tatctttttc atctatagag cctcctgttc 182941 aattgataac tattatcaat tggaattata gagaatgaac agatataaca ccatggacaa 183001 attcctgatt tatcatggac aatctccgga tagtaaagaa acagtttgct gaacgatgcg 183061 ttcgtgcccg caagctgagt attcattcca cgggtcaagg gatagaagat aaacacggtt 183121 atctcgtacc gcgcttaggt tttgccatgc ttctgtctgc tgtaattgct ggtagtaagc 183181 tatggtctcc ggctctttaa aaagaaaaag catcatacag tcagcttggt aatttgcgat 183241 attttctaac gaaatcgctt gttctgaagg tgtgtcagcc gttgttgccg agctgaatcc 183301 taaatcccca aagaaaactt cgcggacact tcggttatga gccagataga agttttgctt 183361 atgcagcctc aaaaagagaa aacgcagccc ttgaacgtgc tgaagtgttt ttttggcggc 183421 cgttgtctgc tggtcataat ccgctagcca cttttctgct tcggactcct cctttaaaaa 183481 tgaggcagtt tgcagaaagt gggttctcca gctttcttct gaaggaaggt acatgacttc 183541 tgcgatgcga ttcaggcgat cttgttcttc tggagaaata gaatccatgc tgacaatcac 183601 atctggttct gcctgtgata acgtgtacag gttttcttcc cacttttcat taaaccggta 183661 tgcactgagc tggacgggta tatctgtcga ataatgctga tagtagtaag acgtccattt 183721 cggatgcaga gcggccgcaa aaggtatgtg gtgaagaggg atgagatggc ccattgtgcc 183781 ccttccgtat gcggcgattt tctttcggcg ttttttcata tagcttgtag gtgaacagcc 183841 tgtatatttt ttaaagattc tgctgaaata aaattcatct tgataaccgg tttggtgtgc 183901 gatttctttc aatttgcagt ttgattttgc catgagccgt tttgcctttg tgattcgtgt 183961 tttcgtaata aattctgtta cgctctgtcc tgtccatttt ttaaagcttt cactgtagtg 184021 tttggcactg attcctgcca tttgcgacag ctgggcaagc gtgatttttg tatcggcatg 184081 ggtttcgata tagtgttttg ttttttcgat tgctgaatgt gtatccgttt gatcagataa 184141 actggcagta aaaagatcat aaatcaggct ttgtacttca atcacacatt ttagctgaga 184201 aagctgagac gattcattcc atagtgcggc aagctcttga agccggactg caagattttc 184261 gatatgtgaa acattcataa gcttcagttt ggctaattcc gattctgtgc acggtgtgaa 184321 aatatcttgc ccggtttcct tgatatagct tagaagcctg attatacagg catctatatg 184381 tccatcggct gctggcgtaa agccaaaggt ctcgttaggc ggacaaacat aaagtgtctt 184441 tttttgcaga ggattggtgt ttgttccgat cgaaatatag ccgtttcctt ttaaatgaaa 184501 aatcagcacg aatgaatcgg ctaattgctg ttctgagaag agatcacttg tcttttttag 184561 atattcaatt tgtactggtt gataaatcac tgcattttgc acgagtagac caccttttca 184621 gaagctttca attgataatc attttcaata aaaattgtac caaataaatg aaagttttcc 184681 tatataaagc gggtgggttt ttagcatgaa aaaaaccctt acttatgtgt aaaagtaagg 184741 gtctttcgtt caataagaat atgttacacg tgtaacatac gatgcttatg ttctaataaa 184801 tgagatactt ttttcttgtt ttgctgaatt gttggagtgt tttttcatag ctgtttatga 184861 tgttctcaac cgaagttcca ttttcaattt ttgtcctgat ccagccgttg cctgccagtt 184921 tatcgaatga acctgttgac aggaactcaa aatcctcagg atagagatcg tgtatggttt 184981 taatgactga aagacccgtt ttaacggctt caaacttatc tctgtctgtc acatagagct 185041 gcacaccgtg gcaaagcgtt ccttgatgtt tagaaaacgt cggtgtgaag gatgctgccc 185101 taaatgtaac gcccggcaaa tggaggctgt ttaatgtttc ttcaagttct gtgcttttga 185161 taaagggagc tccgatcaat tcgaatggct ttgttgtccc tcgcccttcg gatatatttg 185221 ttccttcaat cagcccggtt gcaggataaa caaatgtgct ttccaccgtc ggcatgttag 185281 gcgaagggag gacgaaaggc aatcgggtat cgtcaaaatc catttttcgt ttccagtgtt 185341 tcatttttac cactgtaaga tcggcatcaa tactaaattc tttgttgaac agtgaagcca 185401 attcgcctat cgtcatccca tgcttcaatg gaatgggata caatccgaca aatgaggcgt 185461 attcaggttc taagattggt ccttcaatat gattcccgcc ttgaggattc ggacggtcca 185521 gcaccataaa tggaatgccg ttttctttag cggcttccat tgcgtatgcc attgtataaa 185581 tgtacgtgta gaaacgggtc ccgacatcct gaatgtcaaa cattagaata tcgacatttt 185641 taagcatttc tggagtcggt tttttcgttt ttccgtagag gctgtatacg ggaaccccgg 185701 ttttttcgtc aatgtaagag cctacttcgt ctccagcctg ggcgtcaccg cggacgccgt 185761 gttcagggcc gaataaagct gtcagtttga tatccgggtt ctcgtaaagg atatcgacac 185821 tgctttttag agatgtgttt actccggctg gattggtgat cagtccgatg cgttttccct 185881 tgagctgttt tttatagtct ggcaagagcg tgtctatccc agtctggact ttaggttttt 185941 tagctgtttg attctttgaa tcgggtgaag cagaggcagc ggttatcgtt ccgaacatca 186001 tgagccctgt cagaaaagcg aatattgttt ttctcatgtg tccctcctta ttaaagcggt 186061 cttcccgttt tgatatttaa tccgtagcca agtgggtaaa gggtgttccc tggtttcgtg 186121 actgacggaa tgtcaactgg aagtgtgcct ttaggttttg cctggccgaa tatcgccatc 186181 actccggccg gaatattagg ttgaagataa cggccatttg cgtatccttt aaagccatag 186241 actgcaatca gtgcttttgc ttcttcgaaa ttggctgcgt cataggggtt gcgcaggctc 186301 attaagacaa atggtttgtt gtgctgcagt gcggctttca tgacagctct cggaaacacg 186361 gtggcccatt tgcttgaatc tgatattgtg tcgtcgatga caccgtcgtt gacgacaggg 186421 tcatttttga cgacatagga gccggtaatg atataatcag cctcttttac ttgtttttca 186481 tgctcggtct taaatacttg gctggcaaag ttcattttgc tgagggatac gggtttgatt 186541 ttctttcgct tgatgagatc gtgaatggtt tgttcgattg aagcagtttg ttcttcgtaa 186601 ggtgccacaa ttaagattcg gctgcctttt ttaggcttga acggcaaagt gtgctgttca 186661 ttttttaata cagttactgc tttttcagct aattttttct ctgctttcag gtgctgcttg 186721 cttcctacga tttttttggc tttggctatt ttttcttttg tactgtcgct gtttcgcgct 186781 ggatacatgc cgcgttttat tttcagggaa atgattcttt caactgaatt gttgatttgt 186841 tgttcaggaa tatccccgtt tttcacggct tctttcaaag cttgaataac acgtgcgaat 186901 ttctgttctt ctttcaatga agtgactgag gctggcatta atgcaatatc gacaccagct 186961 tttacggcca tgaccacagc ctcttcctgt ccgaaatgat ctgcgattgc cttcatattg 187021 agcgcatcgg taacgatgac cccattaaag cccatttcct gacgaagaag acctgtcatc 187081 actttttttg aaagtgtagc tggaaccaga atgtccgatc catcgagttt gcttttgtaa 187141 gtggtgtcat caaaggcggg aaactgaaca tgggctgtca tcaccatatc agcaccagca 187201 tcaattgctt tttgaaaagg ataaagctcg acctcacgaa gccgttcttg gccatgggaa 187261 acgagcggca gtccataatg gctgtcaacg tccgtgtctc catgtcccgg gaaatgtttg 187321 agggcagacg cgatatcctg ccgctgcaac cctttcatcg tatataaacc gaggcgtgat 187381 gtcagttctc gattggagct gaatgaccgt acgccgatta caggattatc aggattattg 187441 ttaatgtcca cgacagggct gaaatctgta ttgatgccta aggcagagag ctcttttccg 187501 atgatgctgc cggtctgata cgcattgatt ctgcttctgg ctgcgcccag cgccatattc 187561 cctgggaaat tagtgccctc ccctaacctc gttacaatgc cgccttcctg atcaatactc 187621 agcatgagcg ggatttttgg acttgccttt tggtaatcgt ctgtcagttg gacagtttgt 187681 tttgttgttt ttacattttc tgcaaaaagg atgatgcctc cgaattgata tttcttgacg 187741 aggctggcga cttcatcatt catttttgta agggcttgcg gagaggactc gccttccttt 187801 tgccaatttc taaaatcagg catcagcatc tggccgagtt tttcatctaa cgacatacga 187861 ttgacaatct gattggcatc gattgcacgt ttggatgcag aggcttctgt ctgtctggcc 187921 ccgaaaaagc atgaaagaaa gagaacggct gaaaggataa gcggaaagac aggtctcata 187981 gaaacttcct cctatcgtct aatcattcac tccatcgctt cataaatcgc ggttatgaca 188041 cttccataac tgcctgttgg aaattggtca ccttcaaaga cgttcggatt ttcttccgga 188101 tcaataactg gtgtatgctt tttatttgtt aacaatgcga tgcctaaatt gtatgctgga 188161 tcaataattg taactgtccc cgtccagccg gtatgcccgt aagcattttc gctggcatga 188221 gggccaaaca tccattccat gcttttactt ccgttccgcc tccagccaag agcgaatgtc 188281 ggatctgttg ctgaaggtgc tgtaaacagg tcggctgttt tctgatcaaa taaagaaatg 188341 tttcggtatg aacctttgtt taacatgact tgcagcagta tggccatatc atctgcattt 188401 gagaacaatc cggcatgccc agacacgccg tccattgagt aaaacgcttt ttcgtcatgc 188461 acctctcctt gcagcgtgtt tgtgcggatg ttagggaatt gaataacgcc gtcacgtgta 188521 ttgcccatgc gttcagtagc tgcgaactgt ttcggtttaa agcccttttg cagcggattg 188581 tacaaggtat gcttcagcct gagcggtttg tagagctctt gctccgtgta gacatcaagc 188641 ggtttgccgg tgagtttttc gacaatacat ccgagtagca tatatccaat gtcactgtat 188701 acgtgttttg tcccggtttg ataatcgagc ggaattttcg tcaaatattc aatcgttttg 188761 tcccgttctt gggaatagta cttgccggct ttttccggcg tgtaaaagta aaagcttgat 188821 gggagccctg attggtgctg gaggacatca atgacacgta tcttgtcttt tccttttatg 188881 aggtcacccg gctgatcctt gaaacccggc aaatatgcag aaactttttc atagacgtca 188941 agttttcctt ggctgactaa gcgctgcaat gcaaaatttg ttgcgtacat ttttgtattt 189001 gaggctaagt caaacatcgt gcgggttttc attttggccg gacggcgcag cagttctgat 189061 ccttcgtact ttttactgta gccgtatgct gcttttttta tgatgcgtcc atccttcacc 189121 accacaagaa cggcgcctgg aaatcctgct gcaatatccc gttctatcat ctgatctacc 189181 ttccttagct tcttcgtcga gaattgtgca gtttctgcat ttatgatttt cggctcaatc 189241 aagttgcctg ctgtttgtgc gaaggtttca tttggcgcaa atatcgatag ggttaaaatg 189301 gcactgaata tgaacagtgt ctttgttttc acaggctagc ccctttctgt gcttctatcc 189361 cgtttactat ccctaaaaca gaaacaattt aatcgaactg agaagccatt tcatctttat 189421 atccgaatgc ataggtcaat aaaaaaccgg ccgcgtagga aataaagagc ccaacgatat 189481 acaggatgat ttgcgaaggc aggactagaa aagatagcgg cagtccggag acaccaatcg 189541 caatggtggc tacttgaaaa taagcttgaa aggcgccgcc gattccagct cctaaacatg 189601 ctgttaaaaa cggacggcca agcggcagcg tgactccgaa aataagcggt tcaccaatgc 189661 cgagcagtcc cgatggaagc ccgccggcga ttgctttcct cagtgttgtt tttttcgtct 189721 tcacgaaaac ggcaaaggcc gcgcctacct gtcctgcacc tcccatagcc aaaataggga 189781 gcagaggatc attgccaatt gaattgatca gttccatgtg cacaggcgtc aagccttgat 189841 gcagtccggt tacgacgaga ggaaggaagg ttgcgcccag aataaagccc gcagcgatgc 189901 cgccgatgtc caggatggac agtaggccgg atgtaatagc atcagaaatg aatccgccta 189961 aaggcataaa tacgacatac gttacgattc cggtgattaa cagtgaaacg gtgggtgtga 190021 caatgatatc aagtgattga ggaataaaac ggcgaataaa ttgttcggtg taagcaatga 190081 atatggctgc gaaaaggacg ccgatcagac ctcccctgcc cgggagaagc tcttctccaa 190141 ataaactgat ttttgcgatc tccggattga taatcaagat cccggccaaa gccccaagtg 190201 cgggtgtccc gccaaattct ttcgaagcgt taataccgac gagaatgccg agataagtga 190261 acagccctga tccgatgact gtcaggataa tcgcaatttg tgagtctgca gagagccagc 190321 ctgcttgaat aattgctttg gtaatcccag taattaaacc ggaagcgact agagcgggaa 190381 taagagggat aaaaatgctg gcaattttac gtaagaaaag tttaaaagga gtggcatttt 190441 tccgattgat atcggctttc tttttggccg ctgcttcttt gacatcggca ccttcttctg 190501 ctgacacgag ctttgagaaa gcagctgtaa catgattgac aactcctgtg ccgaggataa 190561 tttgtaaggt ttcagcttca acgaccccca atacgccgtc aagctttctt aaagcctgag 190621 catccgcttt gctttcatcg taaggcgtaa tgcgcaggcg tgtcatgcaa tgcgtatatg 190681 aagaaatatt ggattttcct ccgcatagct caaggatttt ctgtgcgaga tgatggtagt 190741 tattttcttt gctcattaaa acccctcccc ttcaagatgc cttattttat tctcatagat 190801 tgtatggctg ctctcgtttt atctatataa ccggttgtcg tttcatactg ctcagccgcc 190861 atgcctaaaa acaaaacatc aattataaaa agctgggcga ggcgggaaga agtggctgca 190921 cttcgaatca aggcttcatt ggaatgggct gtatacaaag ggacatcagc cagtgcggag 190981 acggatgtct gactgaattg tgtgaggctg atcgttgtga tgcctttttc cttagccatg 191041 gcgaacagtt caacgatttc ctgtgtctct cctgaaaacg aaatggcgaa tacgatgtcg 191101 tctttatctg catttgcgat taaagatgcc acaagatgag tgtctgtaaa cgcggttgct 191161 tgtttatgaa tgcgaagcca cttttgctgg gcgtccttgg cgacaatgcc ggaagccccg 191221 aggccgataa aatgcacggt atgagctttg agaagcagag aaaccgctcg ttcaagctct 191281 ttgtagtcca tcaggtctga agtatcctga atggcttgaa tggcattgcc ggccgttttt 191341 tcggaaatgg agggcagcgg ctcgtgggga acaatatccc ggtagccctg aaacgtaggc 191401 tttgccagat cgcctgctac tctcattttt aaatcttgaa atccttttaa accgagtgat 191461 ttgcagagcc tgatgacggc agcgtcactt gaattggcta aggcgctgat ttcgttgacc 191521 gtgctttcga ttgctttgtg gggatgggct aggatataat ctgcaagttt gcgctcggat 191581 ggagggagct tatgcttcat tgattggatg atcgctaaac cgcctgtggc cattctagtt 191641 ctctccttat catggatggt aatgttcgat tgctttgtca atgaaaccgt ttgcttcatc 191701 gagtaatgtc tgtgcttgtt tctgatctgt gcttgttttg agcatgacga ttgctgtttt 191761 gacgtgatga tcggcttgtt ccagagtgta tctggctgtg tcgtatgaag cgtttgtaag 191821 gctttggatg atgctgatgg cgcgttcttt tagttttttg ttgctgacgt tgacgtctac 191881 catcaagttt tcgtaaacct tgccgatttt gaccattaca gcggtagata tcatgtttag 191941 aatcatttta tgagcggttg cggctttcat acgtgttgat cctgtaatgg cctcaggtcc 192001 gacgacaacc tcaatgctgt gatccgcatc cttgctgatg gcggaatttt cattgcaagt 192061 aagggcgatg gtgtgtgctc cgactttacg ggcgtatctt agggcgcctg cggcgtaggg 192121 tgtgcggccg cttgctgcga tggcaatgac ggtgtcattt gaagtgagct gtatgtttct 192181 taaatcttca gctcctgctt cttcactgtc ttcaatgccc tctgctgcct gtaaaaaggc 192241 ttcggggcct ccagccatga ttccgatgac ctgatctggg cttacgctgt aggtgggagg 192301 acattcaaca gcatccatga cgccgagtct gccgcttgtg ccggcgcctg tatatatgag 192361 ccggcctcca ttttgaaacg attcatatgc gcagtctaca gctgttttga tgtcggggag 192421 aacctcctga acggctgcag cgactttcat atcttcgttg ttgatcattt taaggatgcc 192481 gagagtgttt gctttgtgga tttcaactgt ttgactattg cgtgattccg ttgtaagacg 192541 gtgaaggttt aatggttctg acatgaggat gccccctgtt ttaaaatgat atatctcaat 192601 attcagtata ttcatttctg ttatgatatt tcaactatgt ttttaaattt ttgaaatttt 192661 atttcactta agactataag aaatgatgaa ggatcaactg ttctccaagc ggcccgattc 192721 ttcgccgtcc tttatcaagg aacccgcttt tcatataaag gtgttttgcg cgtatgttca 192781 gatgattgac ggccaagatg atttcgtcgc accatggaaa atatccgctc acaaaagcgg 192841 gaagcaaaag catggctttt ttcgcatagc cttttccgtg atgcacagcg gttaaagaca 192901 gggagctgag cagtaaagca aatggattgt tagaatagga agcaagcgtt tcttttgatg 192961 catgtaaaat gaaaaaaccg actggaaggt cgtcttttaa gatgacaacc gggtatcggt 193021 cctgtatgcc cagagcctga gacagcacct ctttcgggag ggaggtaaag cgtttgtcat 193081 cgttggtgag cgtgaatgat tggagctcgg gcaagtgttc aggcttatag aaggataaag 193141 aaatgtcttg agtcatgggg tggcctcctt acaatatgtc gttaagctcg ttttccgaaa 193201 tgacgcggta gcccgcttgt tttaacagtg cggcggttac tccgctgccg gtgatttttt 193261 tgccagagaa tgtgccgtta tagataaaac cgcttccgca agatggactg ttttctttta 193321 atatgacggc agaagcgttg atttcttttg cgtaagccaa tgttttcgcg gcgccttcca 193381 tatatagttc tgtgacgtct tctcctgaag ctgtcacgat tttcgctgtt ccattgagga 193441 catcctcgcc agtgcctcct atgatttctg cgggttcgcg tggggtagag aagccgccga 193501 gaagttcagg gcaagccatg actgctttct tttcatcgac tagttttctg attttctccg 193561 acgctgcgtg agagccgtta tatctgcatt caatgcctcc aaggcaagaa ctgactagaa 193621 tcatattggt ttctcctctc ttgctttgct tgtctctatc ataaaataaa tggctttagt 193681 tgggaggctt tttcagttaa aaaaggagtt aaaaagtttg aaaataaaaa atttaatttt 193741 cctctttaca aacagggggt gacctgtata taataacttt tgtcagctcg acgagaacac 193801 aacggcccgt tggtcaagcg gttaagacac cgccctttca cggcggtaac acgggttcga 193861 atcccgtacg ggtcaccatt tggaggatta gctcagctgg gagagcatct gccttacaag 193921 cagagggtcg gcggttcgag cccgtcatcc tccaccatct tgccggtgta gctcaattgg 193981 tagagcaact gacttgtaat cagtaggttg ggggttcaag tcctcttgcc ggcactgttt 194041 tttcaaaatt ttatgtggag gggtagcgaa gtggctaaac gcggcggact gtaaatccgc 194101 tccctcaggg ttcggcagtt cgaatctgcc cccctccacc attattgggc tatagccaag 194161 cggtaaggca acggactttg actccgtcat gcgttggttc gaatccagct agcccagtca 194221 cagacacctt tgatcaaaag gtgtcttttt tcttttcgga aaaatcattc caacttctaa 194281 ctgttcagtc tgtataataa ttttaaaaat atgttaaggt agtttattca cgaattacca 194341 tctacaccct gccaaaaatt tgataaactt attttataaa aaaattgaaa ccttttgaaa 194401 cgaagctcgt atacatacag accggtgaag gcagaggtta gataaatatg gaaatgatga 194461 ttaaaaaaag aattaaacaa gtcaaaaaag gcgaccagga tgcatttgcg gacatcgtag 194521 atatttacaa agataaaatt tatcagcttt gctaccgtat gcttggcaat gtgcatgagg 194581 cggaggatat tgcacaggaa gctttcatca gagcgtacgt taatatcgac agttttgata 194641 ttaaccggaa attttcaact tggctttatc gaatcgcgac caatttgacc attgaccgca 194701 ttcgcaaaaa gaagccggat tattacctcg acgcagaggt ggctggtacg gaaggcttga 194761 ccatgtattc tcaaatcgtc gcagatggtg ttttgcctga agatgcagtt gtatcgctgg 194821 agctctcaaa cacgatacag cagaaaattt taaagcttcc tgacaaatac agaacagtca 194881 tcgtattaaa gtatattgac gaactctcat taattgaaat cggggagatt ctaaacattc 194941 ctgtggggac tgtgaaaacg cggattcaca gaggcagaga ggctcttaga aaacaattaa 195001 gggatcttta agtggggtga tgaaatgagc tgtcctgaac aaattgtgca gcttatgcat 195061 atgcatcttg atggagatat ccttccaaaa gatgaacacg tattaaatga acatctggag 195121 acatgcgaga aatgcagaaa gcatttttac gagatggaga aatccatagc gctcgtacgg 195181 agcacatcgc atgtcgaagc ccccgcggat tttaccgcta atgtcatggc aaaattgcct 195241 aaggagaaga aaagagcttc tgtaaaaaga tggttcagaa cccatcccgt tatcgcagct 195301 gctgcggtat tcatcatttt gatgggcggg ggttttttta acagctggca taatgaccac 195361 aatttcagcg tgtccaagca gccgaatctt gtggttcata accatactgt gaccgtgcca 195421 gaaggtgaga cggtcaaagg tgatgtcact gtcaaaaacg gcaagctgat tattaaaggc 195481 aaaatagacg gggatgtaac cgtcgtaaac ggcgaaaagt atatggcctc tgctggacaa 195541 gtcaccggtc agattgaaga aatcaatcag ttattcgact ggacatggta caagatgaag 195601 tctgcgggga aaagtgtact cgatgcattc aatccgaacg gagaagagta aagcgcgtta 195661 gccgctttgc tctttttttg cgggctgaga gggctggcac atttcacttg ctaaatcgaa 195721 atgtggtata atgggctcgc tatgtaaagt acatatgcgt aacacgtaaa acacaaaata 195781 cgaaatgact gaaatcttgg aggacgagga aatggctttt gaggatatcc cttttttgca 195841 gtacctcggc aatgccgttg atattctcct tgtttggtat gtgatatata aattgattat 195901 ggtgatacgc ggcacgaaag cggttcagct gttaaaagga attgtagtca tcgtgcttgt 195961 tcgtatggcc agccaatatt tgggcctcag cacacttcaa tggctgatgg accaagcgat 196021 aacatgggga tttttagcaa ttattattat ttttcagcct gagctgagaa gagcgcttga 196081 acagctaggc cgcggccgct ttttttcgag gagcggcacg cctgttgaag aagcgcagca 196141 gaaaacgatt gaggccatta caaaagcaat caattatatg gcgaaacgcc gtataggcgc 196201 cctgctgacc attgagcggg atactggaat gggcgattat attgagaccg gcataccact 196261 aaatgccaaa gtcagctctg agctgctgat caatattttt attccaaaca ccccgcttca 196321 tgacggtgcg gtaattatga aaaataatga aattgccgcg gccgcctgtt atctgccgct 196381 ttctgagagc ccgtttattt caaaagaact gggcacgcgg cacagagcag ctgtcggtat 196441 cagtgaagta acagacagtt tgacgattat tgtgtctgaa gagaccggcg gcgtcagtgt 196501 ggcaaagaac ggcgaccttc acagagagct tacagaagaa gcgctgaaag aaatgcttga 196561 agccgagttt aagaaaaaca ccagagacac ttcttctaac cgctggtatt ggaggggcaa 196621 gaaaaatgga taaattctta aacaaccgct gggctgtgaa aattattgct ctgcttttcg 196681 cgctcttgct ttatgtggcg gttaacagca accaagcacc gactccaaaa aaaccgggtg 196741 aatctttctt tccgacatca acaactgatg aagcaactct gactgatatt ccggttaaag 196801 cgtattatga tgatgaaaat tacgtcgtga cgggtgttcc gcaaacggtt aatgtcacga 196861 taaaaggctc gacaagcgcc gtgaaaaagg ctcggcagac caaaaacttt gaaatatatg 196921 ccgatatgga acatttgaaa accggcacac ataaggttga gcttaaggcc aaaaacgtgt 196981 cggatgggct gacaatctca attaatccgt ctgttacgac agtgaccatt caggaacgga 197041 cgaccaaaag ttttcccgta gaagtggagt actacaacaa aagcaagatg aaaaaaggct 197101 attctccgga gcagccgatt gtcagtccga aaaatgtgca gattaccgga tcgaaaaatg 197161 tgatcgataa tatttctctt gtaaaagctt cagtgaattt ggaaaacgca gatgaaacga 197221 ttgaaaagga agcgaaagtg actgtctatg ataaagacgg aaacgcgctt cctgtcgacg 197281 tggagccctc ggtcatcaag attaccgttc cggtgacaag cccgagtaaa aaagtgccct 197341 ttaaaattga acggacagga agccttcctg acggtgtcag catagcgaat attgaatcca 197401 gccccagtga ggtaacggtt tacggctcac aggatgtgtt ggattctctt gaatttattg 197461 acggcgtcag cctagattta agtaaaatta acaaggattc cgatatcgag gcagatattc 197521 cgcttcctga cggtgtcaaa aaaatctcac cgtcaaaggt gactttgcat atagaagtcg 197581 atagtgaagc ggatcagaag ttcgagaatg tccctatcaa gactgtaggg ctgagcagct 197641 cacaaaacat tgaatttctt gatcctgaat cacaagcgat agatgtaacg gctaaaggct 197701 ctcccacgaa tataaataaa ctgaaaaaat cagatattga attgtatgtg aatgtttcag 197761 atttagagga cggggagcat agcgtgaagc ttgaagtgaa cgggccacag aatgtaactt 197821 ggtccttggg gcggaaaaac gccaaaatca agctgacgtc taagaaaagc aatacatcaa 197881 cgaatgataa cagcagcaat acatcaggga accaggacac agataaacaa acaaatgatc 197941 aaaagaacaa tcagcaagaa gatacaaaga acactgataa aaacaacaac gatcaaaacc 198001 aagacggaaa taaagatcaa aaccaagatc aggatgagga tgaatccact gcgaattcac 198061 aatcctcatc ggaataaaaa aggagcgatt ataaaatggg caagtatttt ggaacagacg 198121 gtgtaagagg tgtcgccaat agtgagctta cacctgagct ggcctttaaa gtcggacgtt 198181 tcggcggtta tgtgctgaca aaagacaaac aacgtccaaa agtgctgata ggccgcgata 198241 cacgcatctc cggccatatg ctggagggag cccttgtcgc cggactttta tccattggcg 198301 cagaagtcat gcgcctgggt gtcatttcta caccaggtgt atcttatttg acaaaagcga 198361 tggatgcaga ggcgggcgtc atgatttccg cttctcataa cccagtgcag gataacggca 198421 tcaaattctt tgggggagat ggatttaagc tttctgatga acaggaggct gaaattgagc 198481 gcctgatgga cgaacctgag gataagctgc caagacctgt cggagcagac cttggacttg 198541 taaacgatta ttttgaaggc ggacaaaaat atctgcaatt cttaaaacag acagctgatg 198601 aagatttcac aggcattcat gtggcattgg actgtgccaa tggcgcaacg tcatccttgg 198661 cgacacacct gtttgctgat ttagatgcag atgtttctac aatggggact tccccgaacg 198721 gattaaacat taatgacggc gtcggttcga ctcatcccga agcgctcagc gcgtttgtca 198781 aagagaaaaa cgcggatctc ggtcttgcgt tcgacggtga cggcgaccgc ctgattgctg 198841 tcgatgaaaa aggaaatatt gtagacggcg accaaatcat gtacatatgc tcaaaacatc 198901 tgaaatcaga gggccgttta aaggatgata cagtggtttc aaccgtgatg agcaacctcg 198961 gcttctataa ggcgctcgaa aaagaaggca tcaaaagcgt gcagacagct gtcggcgacc 199021 gctacgtagt agaagcaatg aaaaaagacg gctacaacgt cggcggagag cagtcaggac 199081 atcttatttt ccttgattac aacacgacag gggacggatt attgtctgct attatgctga 199141 tgaacacttt aaaagcaaca ggcaagccgc tgtcagagct tgcagctgaa atgcagaagt 199201 tcccgcagct gttagtcaat gtgagagtga ctgataaata taaagttgaa gaaaatgaaa 199261 aagtaaaagc agttatttct gaagttgaaa aagaaatgaa cggcgacggc cggattttgg 199321 tgcgcccttc aggaactgaa ccgctcgtcc gtgtcatggc tgaagcgaag acgaaagagc 199381 tgtgcgatga gtatgtcaat cgcattgttg aagtcgtccg gtcagaaatg ggattagagt 199441 aacgaagtct attatcagag agtgaacaag acaagcgagg tttacataag ataattgtga 199501 gacatacggc aaagttgctt aaaaaacaat tgaccgttta tgccacatgt tgtaaaatca 199561 agcttgtctt gttcttattt tctcaatagg aaaagaagac gggattattg ctttacctat 199621 aattatagcg cccgaactaa gcgcccggaa aaaggcttag ttgacgagga tggaggttat 199681 cgaattttcg gcggatgcct cccggctgag tgtgcagatc acagccgtaa ggatttcttc 199741 aaaccaaggg ggtgactcct tgaacaaaga gaaatcacat gatcttccaa aaaacatgta 199801 ggaggggacg attgaaagtc cccttgaaat ttgactttct tcgtctcctt ttacaatctt 199861 aggaggaaga aaaatatgtg tggaatcgta ggttatatcg gtcagcttga tgcgaaggaa 199921 attttattaa aagggttaga gaagcttgag tatcgcggtt atgactctgc tggtattgct 199981 gttgccaacg aacagggaat ccatgtgttc aaagaaaaag gacgcattgc agatcttcgt 200041 gaagttgtgg atgccaatgt agaagcgaaa gccggaattg ggcatactcg ctgggcgaca 200101 cacggcgaac caagctatct gaacgctcac ccgcatcaaa gcgcactggg ccgctttaca 200161 cttgttcaca acggcgtgat cgagaactat gttcagctga agcaagagta tttgcaagat 200221 gtagagctca aaagtgacac cgatacagaa gtagtcgttc aagtaatcga gcaattcgtc 200281 aatggaggac ttgagacaga agaagcgttc cgcaaaacac ttacactgtt aaaaggctct 200341 tatgcaattg ctttattcga taacgacaac agagaaacga tttttgtagc gaaaaacaaa 200401 agccctctat tagtaggtct tggagataca ttcaacgtcg tagcatctga tgcgatggcg 200461 atgcttcaag taaccaacga atacgtagag ctgatggata aagaaatggt tatcgtcact 200521 gatgaccaag ttgtcatcaa aaaccttgat ggtgacgtga ttacacgtgc gtcttatatt 200581 gctgagcttg atgccagtga tatcgaaaaa ggcacgtacc ctcactacat gttgaaagaa 200641 acggatgagc agcctgttgt tatgcgcaaa atcatccaaa cgtatcaaga tgaaaacggc 200701 aagctgtctg tgcctggcga tatcgctgcc gctgtagcgg aagcggaccg catctatatc 200761 attggctgcg gaacaagcta ccatgcagga cttgtcggta aacaatatat tgaaatgtgg 200821 gcaaacgtgc cggttgaagt gcatgtagcg agtgaattct cctacaacat gccgcttctg 200881 tctaagaaac cgctcttcat tttcctttct caaagcggag aaacagcaga cagccgcgcg 200941 gtactcgttc aagtcaaagc gctcggacac aaagccctga caatcacaaa cgtacctgga 201001 tcaacgcttt ctcgtgaagc tgactataca ttgctgcttc atgcaggccc tgagatcgct 201061 gttgcgtcaa cgaaagcata cactgcacaa atcgcagttc tggcggttct tgcttctgtg 201121 gctgctgaca aaaatggcat caatatcgga tttgacctcg tcaaagaact cggtatcgct 201181 gcaaacgcaa tggaagctct atgcgaccag aaagacgaaa tggaaatgat cgctcgtgaa 201241 tacctgactg tatccagaaa tgctttcttc atcggacgcg gccttgacta cttcgtatgt 201301 gtcgaaggcg cactgaagct gaaagagatt tcttacatcc aggcagaagg ttttgccggc 201361 ggtgagctaa agcacggaac gattgccttg atcgaacaag gaacaccagt attcgcactg 201421 gcaactcaag agcatgtaaa cctaagcatc cgcggaaacg tcaaagaagt tgctgctcgc 201481 ggagcaaaca catgcatcat ctcactgaaa ggcctagacg atgcggatga cagattcgta 201541 ttgccggaag taaacccagc gcttgctccg ttggtatctg ttgttccatt gcagctgatc 201601 gcttactatg ctgcactgca tcgcggctgt gatgtggata aacctcgtaa ccttgcgaag 201661 agtgttactg tggagtaata attaattaac ccctttggat aagaaggtct tcacatgtgc 201721 tgctaggctc caaatgtaca cctttccgta agggcaaagt caaatgtgaa aaaaaactgt 201781 tccaaagtta atcagaaatt tattttcata ttgtatcctt cggtatcaag tgaaaggagc 201841 atcatatgaa aacattatgg aaagtcctca aaattgtttt tgtcagcttg gctgctttgg 201901 ttttgcttgt atccgtctcg gtatttattt atcaccattt ccagctaaat aaggaggcgg 201961 cactgctgaa aggtaaaggc acagtagtcg atgttgacgg taaaaagatg aatgtgtatc 202021 aagagggaag cgggaaggat acgtttgtgt ttatgtccgg ttcgggtatt gctgcgcctg 202081 cttatgaaat gaaggggctg tacagcaagt tttcaaaaga aaataagatt gctgttgtag 202141 atcgggcagg ttatggatac agtgaagtgt ctcacgatga cagagatatt gatacggtat 202201 tggaacagac gaggaaagcg cttatgaaaa gcggaaataa gcctccttat attttaatgc 202261 ctcattcgat atccgggatt gaagcgatgt attgggcaca gaaatatcct aaggaaatca 202321 aggccattat tgcgatggat attggattgc cccagcagta cgtcacgtat aaattgagcg 202381 gagttgaccg attgaaagtg agagggttcc acctgttaac ctcgattggt tttcatcggt 202441 ttataccttc cgctgtatat aatcctgagg tgattcgaca gtcgttttta actgatgaag 202501 aaaaagaaat ctataaagcc attaacttta agcaattttt taatgcagat atggagcatg 202561 agcttttaca gtcttaccaa aacggcagca aatctgtgaa tctgcctgcg ccaaaggaaa 202621 ctcccgtctt gattttagat gcagtctctg accaaaatag acattcaaag tatgctatac 202681 aaaaccgaaa agactatgaa gcgtttgcgg ctcaattcaa tactgccgat ataaaggaac 202741 tgaggggaac acacagtatt tatttatatc agcctgatca aatatataaa ctgtccatgg 202801 agtttatgag aaaggttcgc taggatgaag ggttatcgta ttttaatcgt tgaggacgat 202861 gtgatgattg gtgatttgct gcaaaagatt ttgcagcgcg agggatatcg tgtgatatgg 202921 aaaacagatg gagcggatgt gctttcggtg attcagaagg tggatttggt cattatggat 202981 gtgatgctgc cgggtgaaga cgggtatcaa atgtctgcaa aaatcaaaaa gctggggctg 203041 ggcattccgg ttatttttct ctcagcccgc aatgacatgg acagcaagct tcaaggtttg 203101 cagatcggcg aggattatat ggtaaagccc tttgatccga gagagctgct attaagaatg 203161 cggaatatgc ttgagcatca ttatgggacc tttacgcaaa tcaaacattt gtatattgat 203221 gcggtaacga aaaaagtgtt caatgaaagc ctgcatgatg aggtattatt tactgcgatt 203281 gagcggaaaa ttttctttta tttatatgaa aatagagaca gtatcctgac aaaggaacat 203341 ttctttgaat atctatggca gctcgaagat agaaacccga atattgtcaa tgtgcatatt 203401 aaaaaaatta gagctaaaat caatgatcaa gcgggtgaga tgattgaaaa tatatatgga 203461 gaagggtatc ggctgaatac cgttgtgaag aaatgaagct caagacaaaa tatcagttgt 203521 tattgtttac ggccgtcatt agtgttccga tgctattgct ggcggtcagt gttttgatgt 203581 cggtgattta tgacagcatg tttaaaccga tgaatcatgg tatgcccttt cacaggtcgt 203641 ttgcataccc ggcaatgatc gttgtatttt tgatatcact cttattgtta gcttttttat 203701 tttcaaagtc gattcattct ctgttgcata aaatcaatct attaaatcaa accattcggc 203761 atttggcgag tgatcaaagg gtgcccgata aaattgaagt gaagcgtgct gatgaaatcg 203821 gggaactgat caagtcggtc aatttgttaa ttgaacggac gacatatcgt gaactggagc 203881 tgagacagca ggaggaaatc aaaaaggagc ttttgcaaaa actgcggcat gacattaata 203941 cacctttaac ggctctcagg ctgcagttat tttatttgga agaccaatgt catggtcagg 204001 ctgtattcga atcattgtat cagcaaatcg aatatatctc ggaattaact aatgaattca 204061 atctatattc cgctgagacg ctggaaagct cttatattgt aaatgaagaa gtgcgtctaa 204121 acgagctatt agaaacagcg gtgaaaaagt gggattattt atacagtatg agtgggattg 204181 agctgcacta taagccggca gatcaagatg tgatatggat gagcaacacg ttatggatgg 204241 aaaggctgtt tgataatatt tttcaaaata cgttaaggca ttcaaaagct aaaaagatgg 204301 aagtcacgat tgaacatggc gatgttttta ttcgtgatga cggtattgga tttgatcgga 204361 atgagagcag tgagggactt gggttaaaga ttattgagga tacatgcagg ctgcttgcga 204421 ttacttatga gctgcataca aatgataacg gaacggggtt cttgttttca aaagagtgac 204481 cccgctgatg tttttctttc tcctataaaa tttatataat agggagaaag aaatggggtg 204541 aacatcatat gtttaaaaaa atcatcaaaa cgattaagta cctctcaagc agttctagtg 204601 accgatatcg cagacaccgg cattacagca gcagccggcg cagacattat cgcagctaca 204661 gcagcagttc gggcaaaaga agacactacg accgttatgg cggcagtcat cgttacaaac 204721 gccggagcta cagcagcagt taatccaaaa aaagttcttg ttccgctttt gggacaaggg 204781 tttttttatg tgaccgattg aatggcccgg tttagatcct cgcgaatgga agcggtgtgc 204841 tgatactctt cctcaatgcc caataatctt ttcagcagca aggttacttc ctttgtcagt 204901 gttaattcct ccagccaagt gccgtttttc ttcttttttc ctttatattg agagtacagc 204961 aagaataaca gcgtttctcc gagatcgaag aagtcatcct gttttcgtac ctttatttcc 205021 tccatttctt caggagtcaa ttgtttggca aggccgaaat cgatgaggca gagcctgcca 205081 tcattgatga tgatattagg cgttctgatg tcgctgtgga agataaggcg atcatgcagg 205141 tattctataa tctcaagcag ctgcgaaatc agttgtaacg ccataagctc tgtgaacggc 205201 tgttttcgaa aaaataataa ttcttctata ttctctccct caatgaactg catgacataa 205261 taagcctgtc cgtctatgat gaattcatct atgaagcccg gaatttgcgg gtggtgaatg 205321 tttttgagca gttttatttc ctgctggaat cggactttct ctttttcctt tttggctttt 205381 gtcggccgaa gctgttttaa gacataaggt gtttgagcta ggatatcggt gcacaaataa 205441 accaaaccgt agcctcccat accgaggcac tcttcgattt tgtattgatg atttaagata 205501 acgccgttct ttagagggcg gtcaaatagc agttttttta gaagttttaa tgccatgtct 205561 gcacttccct tggttgtact gactatagtt taccttctag acggagaata aaaaagagcc 205621 ggataaccgg ctcggtataa gttaaaactg ctttgtcacg tcgtattcat aatctatttt 205681 tgcttttacg ttgctcatcg tcgatctggc tgtcgctaat gtattatatt taaaactcca 205741 tacctttgcc acactgagtt gatccgacaa agagatatca taagaccctg aagtcgagct 205801 gtttacaagg gcacggctcc attcgttatt ttcgcttgtc atgatcagat ggcgtgtatt 205861 tccctggctt ggtgtttgag tggcggttgt ttgaactctg gttacaatgg catcacgcgg 205921 tatcccagat tggtttgtta aatcaacctt gatcacgctg gagtcagaac ctgaggggct 205981 aaggcttgta tttcctttat tttcagcaac gccgctgaat tggaacgttc cgctgcctga 206041 tttgattcgg tcttcaattg aaagcgtaaa gtacatgttt ccagtatagg tgcctcgtga 206101 cactttcaca tagaaggtat ccgtcgtgtt ttgggcgtct gcatttgcat aaataaaaga 206161 agaaaacgta ttagggttaa taacttctgt cccttgagaa acaggtattc tgttcttgtc 206221 ataaatttca attttcatcc ctgtatacgc gctctggtat gtactcctca tgtatacttt 206281 ttctccctta ttagccgtaa aagtgaaata ggcttcatct tgaccagctt ccagtattgt 206341 tgtatcgata tttttatatt tccaataacc gatcggcatt gcggtatcaa atgaattgtt 206401 tcctgtgata gcagtgactc cgacagctga tgccgaatac gtaaaggtag ataagacaga 206461 aagcataaca gcgaattgaa taagccattt tttcaccatg caaacaacct ccttttattt 206521 ccatcataca taataacgat ttaggtgtaa ataaatgttt tttgaggtta atatatacat 206581 tatattcgcc gataaaaaag aataagagag aatactcggg agggaattca atgcgtctga 206641 atcggcaatt tatccgcact cagctgattg cacagaacat attgagcaag aatgcgcctg 206701 ccaaacggga gaatgcgact gaaaatccag cggcagttct ggaaaaggca tatagcaggc 206761 ttaagtcaca atcttcaact gggggaatca atcagttcaa ttattctaaa accagcgtgt 206821 cgggaaacag cgggacgttc agcaaagtgt atcaatcagc gaatgatcga acagtgacag 206881 acacagggga agaaacagtg attcaatccc aaaaccccta tgaatctgag agtgatatca 206941 gaatcaaaat actagatgaa aaatacagca ggatgaatgc gattaataaa acaaagtctg 207001 atccattagg ctatattaag gataagtacc aaaattcaaa gtctccttat ttcagaagtg 207061 atctgtcagc tgcagaaaga caggccgctt acgataatga aacagaatgg ttattcaaag 207121 ggaaggcgca aaactataac cttcaggatg ctgtgtttcg gaatgtcaca tttcatgggg 207181 aagtggaagc tgagaatgaa aaggtgtatc agcggggaca ggttaaccag cagctgcaag 207241 tactgttgaa tcgaaaccat attcatattc cagaggggac agagctgacg tttacaatca 207301 caccgattga ctatcaggtg cgggtaagcg ggacagacga tcaggatctg atcaagcaaa 207361 ttgagcaagt gctgcaatct ggagacaaca gcaaagaact atttttacac atcatgaaaa 207421 gtcaaagcag tgattcagca caattttccg aagaggccta taaaaagtat caggcagctc 207481 gtgagatgta tgaagttaca ggctaccatt tgaaggattt agaagtgatt gatgggcggt 207541 acgtcacgcc tgagggacgt gacttaatgg atgtatataa ggaagagctt gaaaaagatc 207601 cagtgcagaa acaaacggct tcttatgcta tatcttacta tcgttcagag ctcagtaaaa 207661 tcgcggaagc cgggtataat gccattccgg atttcatcct atcaattgat tacagcaatg 207721 gatctctgag agatgtggga caaagcaaga gctatgggac cggagatacc gggtggcttg 207781 aagcattaaa gcgtcaaacg ggtgtgaatt attaggtaag ctgttcatgt aggacagctt 207841 attttttatg agaatctaag gggtgaatta atcccaatat tcaaataatt ttattatttt 207901 tatataaaag attttaaaag aagtgaacga ttcaaaactc tgaacaaagg tgtttacctg 207961 aaaaaaacaa ttgtattttc cagagaaatt tattatgatg aaataagtaa tttaggagat 208021 tatataacaa ttttaagttt gaattttctg attgttatca ctgattcatg tgaaggcaag 208081 caggtctgct gttttctcat ttatgagtat tttgttagga ggaggaagag gagtggcaaa 208141 taaagaatta aagaggggcc tgggcgcgcg ccatattcag atgatcgcct tgggcggtac 208201 aatcggtgtt ggcttgttta tgggttctgc cagcacgatt tcatggactg gcccatctgt 208261 ccttctggct tatgcaatat gcggaatttt tatctttttt attatgcgtg cgatgggtga 208321 aatgctgtat gtcgagccga gcacaggttc ttttgcgacg ttcggccatc aatatattca 208381 tccgatggca ggttatataa cagcatggag caactggttc cagtggatta tcgtcggcat 208441 gtcagaaatt atcgctgtcg gttcttatac gaagtattgg ttcccggatt tgcctgcttg 208501 gatacctggt atcgtggcaa tggtgattct tggtgcggcg aatttaattt ctgttaagtc 208561 gtttggggaa tttgagtttt ggtttgcgat gattaaaatc gtgacgatta tcttgatgat 208621 tattgcggga atcggaatta ttttcttcgg ttttggcaat ggcggagatg cgatcggttt 208681 gtcgaacctg tggtctcacg ggggcttctt tgcaggaggt ttctcaggtt tcttctttgc 208741 actgtctctt gtcattgcag cctatcaagg agttgagctg atcgggatta cagcgggtga 208801 agcgaaggac ccgcaaaaca cgctaagaaa tgcgattcaa agtattatct ggcgtatttt 208861 gattttctac attggcgcta tttttgtgat cgtgacggtg tatccttggg atgagctcaa 208921 ctcactcgga agtccgtttg tgtctacgtt ctcgaaaatt ggaattacgg cagcggccgg 208981 cattattaac tttgtcgtga ttactgcggc aatgtccggc tgtaacagcg gtattttcag 209041 cgcgggccgc atgctgtata cactgggtgt caatggacaa gcaccgaaat tctttaagaa 209101 gatttcacgc aatggtgtgc cgctgtatgg cacaattgcg gtgctgatcg gtttggctgt 209161 cggcgttgta ctgaactata tcgcgccgcc gaagatcttt gtctatgtat acagcgcaag 209221 cgtgctccca gggatgattc cttggtttat cattttgatc agccatatcg gattcagaaa 209281 agcgaagggt gctgcattag ataaacatcc attcaaaatg ccgtttgctc cttttacaaa 209341 ctatttgacg attgctttct tgctgatggt tctggttggc atgtggttta acgatgatac 209401 tcgtatctcc ctgattgtag gcgtgatttt cttagcgctt gtggtcatta gttattatgt 209461 gtttgggatt ggcaaacgca cgcaggccaa tttgacaaaa agcgaacaag cagctgaata 209521 acgataaaaa agagacattc acggatgtct ctttttttat ttttcgcgta tggattttcc 209581 ctattttagc aagctatagg gtaaagatag cagaaggaaa ggtgttcata aaatggatgt 209641 tacactcggt tatttgcgcg aatcactttc gaatcatcta gaaaatgaag tctgccagcg 209701 tatttgcaag aagatgctgg cgaagcgtta tgcaaatgaa gaggaatttg taaaagactt 209761 agatgataat gaaatgtctt ttttgaacca tgtattagaa aaagaaatta agtatgccca 209821 gaatgaacag gatcaaaaac gggccaagga attaaacgag gtgtatgaat tactgctttg 209881 agaaaggcgg gtaagaaatg ggagcaattg aacgaagcgg atatacattt cagccggagt 209941 ttagcgttgt ccgtcaaaac ggagccatcc atgtgtacca tcaaggagaa tttgtggaag 210001 aaatcgaatt tgaatttaac ggggaatatc ccgatcatga tttgattgaa gagcttgtga 210061 atcattattg ttttgagcat gagatttaga gccctgccgt gcagggctct tttatttagg 210121 atgtaatcag gccatacttt ttcaggatat ccacggtgat gtttttggct tttgtgccgg 210181 aatcatcgac attggtgaca aagacataag agccatgctc tgttttgatg aatccgacaa 210241 accatcctaa tcccatatca gtcaggcggg ttccggtttt cccgtagagc gtgtaatgat 210301 cgccttcctc ttgaatcatc atgcgcttga cgattttcat caccggcttg tcaaatggaa 210361 gctcctcttt agccagtttc tccaaaaaag tttcttgttc cagcggagat attgtgagcg 210421 agctttgcag ccaaaactgg tcgattcccc cgctgatatc ctcgttgccg taagatagag 210481 tatgaagcca tgttttcatt ctttcctcgc cgatatctct cgctaatgcc tgataatacc 210541 agattgcgga ttcgcgcatg gccgagccaa gcgtatggtc gcggttccat gattcgaatt 210601 cacgcttgac cccgtcccat cgtttaacat cgtattcatc tcttacagct ttgacctgca 210661 aaccgattaa agcgttcacg actttaaagg tggattgcgg agtttgtctt tgatttgccc 210721 gttttctgtt atagacaaat gtctgatcct tttgtaaatc gtgaagaatg aaggttccat 210781 ccgtatcctt gaattcatca tcgacattca ttttgctgac attcaagtgt ttttcatgag 210841 cagatgatgc tgcgtggacg gagaagccgc cgatccctgc aatactcagc acaagcacaa 210901 catatatcca ttttttcatt ttgttctccc cttcgttttg attaactacc ttttctctct 210961 ttcgtttgtt cttcctttaa aaaataatca aaaagcgctt aaatttggtt ttgcaaacaa 211021 atactgttac tgggtttata gtcggaagat aacgtgaaaa tagagggtaa aaaggaaggc 211081 agggtaagcg gatgaatgag cagattccac atgacaaaag tctcgataac agtctgacac 211141 tgctgaagga agggtattta tttattaaaa acagaacaga gcgctacaat tcagatctgt 211201 ttcaggcccg tttgttggga aaaaacttta tttgcatgac tggcgctgag gcggcgaagg 211261 tgttttatga tacggatcga ttccagcggc agaacgcttt gcctaagcgg gtgcagaaat 211321 cgctgtttgg tgttaatgcg attcagggaa tggatggcag cgcgcatatc catcggaaga 211381 tgctttttct gtcattgatg acaccgccgc atcaaaaacg tttggctgag ttgatgacag 211441 aggagtggaa agcagcagtc acaagatggg agaaggcaga tgaggttgtg ttatttgaag 211501 aagcaaaaga aatcctgtgc cgggtagcgt gctattgggc aggtgttccg ttgaaggaaa 211561 cggaagtcaa agagagagcg gatgacttca ttgacatggt cgacgcgttc ggtgctgtgg 211621 gaccgcggca ttggaaagga agaagagcaa ggccgcgtgc ggaagagtgg attgaagtca 211681 tgattgaaga tgctcgtgcc ggcttgctga aaacgacttc cggaacagcg ctgcatgaaa 211741 tggcttttca cacacaagaa gatggaagcc agctggattc ccgcatggca gccattgagc 211801 tgattaatgt actgcggcct attgtcgcca tttcttactt tctggtgttt tcagctttgg 211861 cgcttcatga gcatccgaag tataaggaat ggctgcggtc tggaaacagc cgggaaagag 211921 aaatgtttgt gcaggaggtc cgcagatatt atccgttcgg cccgttttta ggggcgcttg 211981 tcaaaaaaga ttttgtatgg aataactgtg agtttaagaa gggcacatcg gtgctgcttg 212041 atttatatgg aacgaaccac gaccctcgtc tatgggatca tcccgatgaa ttccggccgg 212101 aacgatttgc ggagcgggaa gaaaatctgt ttgatatgat tcctcaaggc ggggggcacg 212161 ccgagaaagg ccaccgctgt ccaggggaag gcattacaat tgaagtcatg aaagcgagcc 212221 tggatttcct cgtccatcag attgaatacg atgttccgga acaatcactg cattacagtc 212281 tcgccagaat gccatcattg cctgaaagcg gcttcgtaat gagcggaatc agacgaaaaa 212341 gttaaattaa aaagctctct tcctttatcg aagagagctt tttgattact tctttttttc 212401 atcgtagtat tggacgggat acatggagcc ttctgatacc attttgttgt cctcgatatc 212461 ttgcgggtcc gggtggccgg ctttatcaac tgggaacgtt tccatgtctg gctgttttgt 212521 tattttcatc ttcatgctgt gaatgaattc tcttgccttt tggcgatttg acgggtcttt 212581 taatagataa gaagtgatgc cgacagttga aacagcgaga cctgaaagta acagcttttg 212641 tttcatggtg atactccttt ctattttaag aatagtgttt cctgtatcat tcccgttttg 212701 gaaattgcta aacctgttgt gtttttatca ttggaattaa cagtaaattc catttaagaa 212761 gaaactagtg acttcattcc tgtattggaa ggtaatatac attgacttat tatagatttc 212821 agtcaaaatt cgataaatat tgacaaagta aagtaatcag aataataata taattagcaa 212881 gagaatgtca tcatacatga aaggtgttta cgatatgaat caattgcatc gaagaatggg 212941 aacgttttcc ctcatgatgg tcgggctcgg gtcgatgatc ggttcaggct ggctgttcgg 213001 ggcttggcgt gcggctcaaa tagcaggacc agctgctatt atttcatggg ttattggaat 213061 ggtcgtcatt ttatttattg ctctttctta tagtgaacta ggttctatgt tccctgaagc 213121 ggggggaatg gtcaaataca cgcaatattc acacggttcg tttatcggtt ttattgcggg 213181 ctgggccaac tggattgcga ttgtgtccgt cattccggtt gaagcggtgg cctccgttca 213241 atatatgagt tcttggcctt gggaatgggc gaaatggaca agcggtttgg tgaagaatgg 213301 aacgctgact ggggaaggac tagcgtttgc ctctgtattg cttctcattt attttctgct 213361 gaactactgg acagtcaatc tattttcgaa agcgaattca ttaattacga tttttaaaat 213421 tattattccg ggtcttacga ttggagcttt gctgtttgtc ggattccacg gagaaaactt 213481 tactggcggt caaagcattg cgccgaatgg ctgggcaagt gtgctgacgg cggttgccac 213541 ttccggtatc gtttttgcgt ttaatggttt ccaaagcccg attaatatgg cgggtgaagc 213601 aaaaaatccg gggaaatcaa tcccgattgc ggttgttggc tctctttttg ttgcgacagt 213661 gatttatgtc ctgctgcaga tcgccttcat tggagctgtg aatccttctg atattgctca 213721 cggctggagc catctgaatt ttaattctcc ttttgctgat ctggcgattg cgctgaatat 213781 taactggctt gttattgtgt tatatgcaga tgcatttgta tcaccgtctg gaacggggat 213841 tacgtatacg gcgacaacgt cccgaatgat ttacggaatg gaaaaaaaca aatacatgcc 213901 gagtatattc gggaagcttc atccgattta cggcgttccg cgacaagcaa tgttctttaa 213961 cttgattgtt tcgttcatct ttttgttcct gttcagagga tggggcgtat tagcggaaat 214021 tatttctgtt gctacgttaa tttcttatat caccggcccg atcacagtga tgacattgag 214081 acggacgggg aaagacctgt acaggcctct tcgtttaaaa ggcttaaatg tgattgctcc 214141 gcttggattt atctttgcgt cactggtgct gtattgggcg cgctggccgt taacaggaca 214201 ggttctgttt attatcctga tcggtcttcc gatttatttc tattatcagg cgaaggcgaa 214261 atggaaaggg tttggccgga actttaaagc cggcgtctgg atggtgtttt atctgctggc 214321 catgatggtt atttcttatt tgggcagtga taaattcggc ggcctgaatg tcattcatta 214381 tggctgggat atggttctga ttgcgatggt atcccttgta ttctatgtgt gggcgctgaa 214441 gagcggctac cagacagaat acttaaagga tgcgaaagag ataaattctc agctgcttaa 214501 tggacagtca gaagctgctg ccggaaaaga ataaaatata gaagaaaacc ttgcgatagt 214561 tgtcgcaagg ttttttgctt ttaataaccc ttttttactt tgtggaaaag atcaggatag 214621 ttggtgaaca ctcctgttac gccccaatca agcaggcgat gcatatcagc ttcattattg 214681 actgtgtaag gatgaagcag gaggccgtgg ctgcggatca tacggacgtt ttcttgattt 214741 aaagctttat aatccgggcc cgcaccgaca gcgtatgttt tgatttcttc cagggcagca 214801 tctgtcattg acgccatttg tttggcttcc agcaattgaa cggtcggcag gtttggctgt 214861 aattgatgga cttttaccag gctttctttg ctgaacgatt gaatgatcac ctggcctggc 214921 ttagaatgct ttcccagtaa tttatgtttc tgcaaagaag cgatcagttt ttcttccata 214981 cctgggtagg tgtcaggcga ttttgtttca atgtagtagt tcgcgtgctt tccgaaacgg 215041 tctaatacct cttctaatgt aggaacttta aggccgacgt actgcggctt tgctttttcc 215101 ggataggctt cattaaacca agaaccggcg tcaagcttct taatgtctgc gagcgtatgg 215161 tctttcaccc aacccattcc gtttgtggtg cggtccagtt tttcgtcatg catgacaatc 215221 aattttccgt cttttgtcat ttgcagatcc aattcaataa aatcagcttt cattttctga 215281 gcggtttcgt aagacagaat cgtgtgctca ggcacatatc cagaagcccc tctgtgcgcg 215341 acggtcagga tacggtcagg tgacagcagg tttccttttg acgctgccga cactggcgtt 215401 accataaatg agagtaagcc cagcgacaga acaaacaagg ccagtattct attttttctc 215461 atgatttctc ctccttatag ataagcacta cctgtctttc ataataaaaa acggatgtaa 215521 acggcgtgtt ggaaaactat taatctttta tgtgtctttc ttaaacatgc tctgcccgtt 215581 ttcctgtatt ccacgtcaaa gccaagaaga cgatggcaag aatgcaggat gagatcagca 215641 tgataaagcc gccgttccag ttaaaacggt ccacgacaaa gcccataatg gcgtttgcga 215701 aggcggatcc gccgatgtat ccgaaaaatc cggtcaaacc ggctgcagtt ccggctgctt 215761 ttttcggtgc taggtcaatt gcttgaaggc cgatcagcat aacaggtccg tagattaaga 215821 agccaatgct gatcagggcg atattgtcca cgagcggatt gccggccgga ttcagccagt 215881 acaccaatac ggcaatgaaa acacccgcca taaacaaaac gcctgccggt gcccggcggc 215941 ttttgaagaa tcggtcactg atccagccgc acaagatcgt tcccggtatg cctgcgtatt 216001 cgtaaagaaa atacgaccag cgtgagtctt caggagaaaa gcctttggct tctgttaagt 216061 aagtaggcgc ccagtcaacc acgccgtatc gcacgaaata aacaaataca ttggcaaaag 216121 cgatgtacca aagaaatttg ttgttcagca catattgaaa aagaatttct tttgttgtta 216181 attctttttc ctgattttta aaagcgtgtt ttggatagtc attccgatac tcttcaattg 216241 gcgggagtcc gcaggattga ggcgtatcac gaaccaataa aacaattaaa aatgaaatga 216301 taatggcgat gatggcaggg aagaaaaaca cgcttttcca agtgacgaac atcgcgatcc 216361 caagagtgac aagcggagca agaataccgc cgcctatgtt atgggcgaca ttccagatcg 216421 acatttttgt gccgcgttca cttatggaga accaatgggc catcgtcctg ccgcatggcg 216481 gccagcccat tccttgaaac catccgttga taaacataaa aataaacatg atggtgacgc 216541 tcgaagtcac ccaaggcatt gaaacgaata gaatattaac gattgctgat aaaaataggc 216601 ctgtcgccag aaaatatctc ggattacagc ggtcagacac cattcccatg atgaatttgc 216661 tgaagccgta cgcaatggac acagcggcca gcaccaaacc cagttctgtt ttcgaaaatc 216721 cctgttcctg cagataagga atggcaaagg caaagttttt ccgcagcagg tagtagcctg 216781 cgtagccaat gaaaatacca atgaatactt gcagtctgag ccgtttgtat gccgcatcca 216841 tctttgaatc atccagtctc tcaatatgag gagccggttt aaatatatta agcattaata 216901 attatccccc tttgctgttt gtgctggatg tgtggcgtgc ctcctttccc gaaaaacaaa 216961 aagagccaga aaacacccct tgtcaaaagg ggttggattc ctggctctcc tcatctccat 217021 ccaagctatt aacttatcat gatagcgctt tcttaaatta tcatagtccg gagcgaatgt 217081 aaacgggtaa ttttcaaatt gggccttagg gaagtgaata ttatcctttt actaaatgca 217141 attatatttt tttactagta acataaaaat ctggagggag gctgtttaaa gatggatgaa 217201 ttagatatcg cattctttat tttaccgtta ggaattatgc tgctatcgat tgtcgggacc 217261 tgtatttgta aaaacccgta tctgatgcca atgcttagtt tggtgatttc tcttgtgctc 217321 acctttacca tttttaatca atcatttttg ggatgggctg ttgtctatag cttggtttct 217381 ctggctttat cctatatcac attgattgtg gtaaggaaaa ggaaggaatc aggaaattaa 217441 aaagacctca ctttctaaca tatcgttgac taaagcaact atatgtgatt ataattgctt 217501 tagtcaacga tattagaaag tgggaattga tttgaaaaca agagaatcat ctgtcgggtt 217561 aaaattcaga aagttcaatc gattttatac aaacgtcctt ggtttcctta atgagcacat 217621 ttacgacagc ccgttttcct taacagaaac acggatttta tttgagattt ataatacgcc 217681 taattgtacg gcaaaagctc ttcaggataa gctggggctt gaccggggat atgtcagcag 217741 gattgtgaag cagtttgaaa aagaagattt gatttataaa cagaggagca aagatgacgc 217801 ccgccaccat tacatttttg tcacagaaac aggaaaaacg atttataaaa agctggagga 217861 gaaagccaac gaacaagtag aactgatgct gaaggtaatc aaccaaaagg agcagcacaa 217921 gcttgccgag gcgatggcag agattgaagc gatcctttca cagtcgcttt ctgccagagc 217981 atcagagata tcgattagag attattttct ttcggaggat cttcaactcc ttattgagaa 218041 acaaagacaa ttttacgcgg aggctcacgg ttgggatgac acgtttttag cttatcttca 218101 ggagacattt gacgctgaca tcgaaaaaat atggattgcg gaaagcggcg ggaaatttgc 218161 cggctctgtc gggttggtca agcacgatga aaagacagtc cagctcagat ggtttctggt 218221 tgatgcggat tttcggggca gggggcttgg cacgcaattg ctggagcatc tggttgcata 218281 ctgccaagac atgaagtttg accgcatttt cctttggacg gtgagcacga tggctgaggc 218341 tcgtccgctc tataaaaaat ttggattcag gataagtgaa gtaaaacaag aagcgccatt 218401 atggggacag cagctgacag aagaacggtg ggatttggag ctgtcatgaa aagactgcat 218461 tatgcgtgga tcatcgtctc cgtcaccttt ttgatcttat tggcggttca gggggtgcgg 218521 ctgtcgtttg gtgcgtttgt ggagccgtgg gaacggcagt tttcaatcga tagaagcacc 218581 atctcgctga tttcgacggt gagttttatt gtttatggca tatcacagcc tgtgatcggt 218641 cggcttgtgg acaaatgggg tgcccgggct gttttggcat ggagtgcgtt actgacagga 218701 gtcagcattt tcttaacata ccttgtgact tcgccttggc agctgttttt gctttacggg 218761 ctgggtgtct cgcttggagt gggcggagca tcgaatgtgg cggcaagtgt attggtcgtc 218821 aattggttca gcaaaaagcg gggactagcc tttgggatca tggaagcagg ctttggcgcg 218881 gggcaaatgc ttctcgttcc cggctcactc atgttgatcc attggtttag ctggaagctg 218941 acggttgtgg tgttgggact gctgttaatc gtgattgtct ttccggctgc gctgctgatg 219001 ctgcggaaca atccttcaga aaagaataca gagccgatag gcggactggc tgcatcagaa 219061 aaagaaacag cacccaaaac aacagctctt tcagtggccg ggatgtttcg tatgaggcaa 219121 ttctggttct tgatttttcc gtttttgatc tgtggattta cgaccgtggg gctgatggat 219181 acccatttga ttccgttttc tcatgatcat ggcttttcaa cgacagtcac gagtgctgct 219241 gtcagtctgc tagcaggctt taatattgct gggatcttgc tgtccggaat tgtagcggac 219301 cggtggagca gccggaaaat cctgtgcatt ttatatgcgg tgcgggcgct gtcgatcgtg 219361 attcttattt acagccacga gccctacttg cttttagcct ttgcgattct gtttggatta 219421 gtggactttg caacggtagc accgactcaa atgctcgcca cccagtactt tcaaaactac 219481 tcgatcggcc tcatgattgg ctggctgtca ctcgcccatc agatcggatc ggcactaggt 219541 gcgtatgtgc ccggcgtcat ctacacggta acgggtgagt atacactggc tttttatttg 219601 tcgattggaa tgctcgtgct tgcgagcgta atgaatgtga tgctgaggga gccagctgcg 219661 gttacgcgtg acagtgcggc tgtggtagac aagtgatgag gacaaaggga aagcatctct 219721 gatttcgaga ttattcagag atgctttttt tgtatttttg ttctaatacg aagtcgatca 219781 taccgactat gcgggcgttt tcggattttt gtttgaagcg ttcagaaatt tgaacttttc 219841 ttgaaaatgg ggaaacaata aaaacccaaa aaaggccgat caaggcaaaa aacatttgta 219901 cagctaattc tattaattca ttaaaacgag tgctgaaaaa atagaagtat aacgttatta 219961 atgtcacagt acatacgatt ttggcaagtg tgtttgaatg taagcaatgg ttcactaaag 220021 aataccttta attgattcag catgattgaa tcatatttgt ttaggaaaat aagaagttct 220081 ttatcatctt ttttatgttc taaaataaag ttgctgtttc tgtttcttta tatgtatggt 220141 ggtctacatt caatatatac atctcttaaa gtataaaaat tgagtatttc ttagtaagga 220201 tgaaacaaaa ttacatgatt tttttgttat atctttcagt tagaataaaa tctataactc 220261 ctctcattcg caaatattcg gctctctgtg caaagtgcag aacagtatgt aattgtcctt 220321 ttctagatat atttaaaagc tttatcaaat caataaggat tttcaagaaa ataattaata 220381 atagaaagat aaaaatgtgt ggtatgtcaa tgtaattgat ttgtcctgaa aataaagaag 220441 ttgcatagac aacaataata cttccgcaaa acatcaaact catataatgt ggaagggaaa 220501 atggacgagt tgaaaaatat gcttttaatt ggcttagcat agcattatct cttgtatcta 220561 agtagcccaa aagctcttta tcatttttac taattgtaag aacatgattc aatacagcac 220621 taaaattcat tgaatcttca ttatcagagg cagtatgttt attagcctgt atgttttgtt 220681 gatccatttt atatttttta taaagtattg tattaattaa cttgtttttc tcatagaatt 220741 cagatcgttg attaagggat gcttttcctt tgtttttatt tccttttttt atgattttag 220801 tataagtcat aaaaatacaa atgactgtaa aaatagaaaa cactgcaggt gaaatatctg 220861 aaagaatagt attggtgaag acttcttttg cttggatgaa aaggaaagaa gctaaagtca 220921 tagatataaa catgcataaa actgctactt tcacaagaaa ctgaagcgga agagaaggtt 220981 ccgaataata gtgcttcaac tggttgagtg tcagagaatc ttggcgaaaa agataatcta 221041 ttatctcctg ctgattttgc atctgattga tatcatgagc gatgtttttt gttttttcaa 221101 aaactatttg atcatttttc atttttgata aacctccaaa agacgataga taaactaaaa 221161 aaactgcatg agcatatttt aacttatgtt catgcagttt tgtattaaag ttagctagta 221221 taataagcaa aaatggccag taacatagca gataatgcgg tagcgacttt gactccttta 221281 ttgttcgtta aatcactgcc catattccca attagtaaaa gtgcagcaac acctacaaca 221341 gggaataaat attgatcata agacggccaa tctaacgcta attcactctc gggagacgta 221401 actggtactc ccttgtacgt ctttatttta aacgtaatcg tagtcgttag tccagttgtg 221461 acattgtcac cgactggaat atcaggtgta tagattttaa tttgaatgtt taaagattca 221521 gctgttggat ttacataaac ctccaaataa ccgttgcgta ctgataagct cagactattt 221581 aaaaggtttt gataagagtc gatttgtgac gcagtgagag acgtttgagt gtcgcccaat 221641 aaacccgtga tataggcacc tggtttacca tttgtaatgg taattgtgtt tggtgaacct 221701 tcacttggta tggttgccag aagtgaagtt gatagaataa tatccaactc aggtgatgtg 221761 aaaatggttt ctgtcgtatc aaattcaaac atcgcgtttg ccagacttgt tagattttct 221821 aaagctggaa tggtagataa aatgtctgtc agtgtacgca gtcttgcatc atataccgga 221881 tcagacggcg gatttacatt gcttgcacct gagtctcttc ctgaataccc gtctttatca 221941 atcccgatgc ttccagagcc gcttccgatg gttccttcat aaaattgatc aaaggcccag 222001 ttgtttggca tcggatagcc gagattgccg ctaaatcctg ttgacatatt tgccacaaaa 222061 ctatactttg tcagtcctgc ttcagatgta cggatacaaa tgtttcttgg tccgtaaacc 222121 cctatttcat acttaggtgc ggttgaaaat gtctgcattt ttgtaaatgc tgacttaatc 222181 tcttggaaat aaggaatgat tttatcggtc acttcataat cgtatgcatc aaaatcgaca 222241 gcgaaataaa tggtcgtgcc tgacggaaaa cctaatcttc tagcagcaga agcggcacta 222301 tatgcatctc ttgtgccttg gtctttgaca aaataagaag attcatagcc gccgtcttga 222361 taaattggga aaaccttcaa tccggcatca agaataactg caagctcttt agatgtcagg 222421 gctttagatg tgaggccgct gcttgtccgc acatttccgg tcaaatatct gccaaccgtt 222481 ttataaccgt tattccgcag tgtttgagct ttttctgcgg ttataattgt agcagtgtca 222541 caagcagaag cggtgcgagt tgtgtctcct gagcttgata ataaagcttt aatggttggc 222601 atatctgcat aacctgtttg cggcaggcac atgaactctt gaaatgcttt aacagctgaa 222661 acaacaccca caccatattt gccgtcaaac tcaccaggat cgaacgattt tccgttacaa 222721 tagagggcgt actgaacaat taagacaaat cctgttcttg aatcgccggg agttaaagta 222781 gggcacaaac ttgtggtgcc gtttccgaaa aatccattgg caacacttgt gctcatgcct 222841 tcttcttttt gcagggcata aataagagct ttatttgtat cgcggccata cagtccgtca 222901 caaggcatta acccgatata gtcattgtag tctcgattta agttttgttg aatctggcga 222961 attcttgaat cacccccaga caccagctta aaagcgctca tgtctaataa ggctttcata 223021 attaacgtgg tgacaatccc atcctgtgtt gtcagtccgg cagctttttg aaattctttt 223081 accgcatttt ctgttttttc gtaaaagacg cctgtaaaac cgccgggatt aaagccttta 223141 caccataaag ccccttgtaa aataaaattc atgttgcttg gttttgaatc tggagcttgg 223201 cgtttaagag gcttaaataa gcgctgtgtt gtcggcccga agttatcggc tggctctgag 223261 atacccaatt caatttgaag cgcccgagtc agaccgtaga tcgtatccca cccagttttc 223321 ccgctttctt caactgggtt atacccatgt ttgccgctgt acgtatcgtt cagccattgc 223381 tgtgtgatta agaccatttc atcaaccatt tcgattcctc ctttgttaga ttgcgttcat 223441 ttataggtgg caaacgtagg acaaaataaa aaaatggatg ccgttaagca tccattttac 223501 atccgttctc caacagcttc gctttcggtt tcagctctga aatgtagagg cctaaaagtg 223561 taagcgcgcc tcctagaaga gcgatccatg tcatgttttc gtgcagaatc aggacagaag 223621 cggcgatcgt gataaccggg accatgtaaa tatacgcact ggatttgacg gctccgagca 223681 ctccaactga ataattccaa gtggcgaagc acagggcaga agcgccaatc cctaagaaaa 223741 gcatgttgag tatatttgaa gcagatgaaa atcggcttag gtcaaaatgg aagtcgaaca 223801 aaaataaagc gggaaccata aacaataaac catacaaaaa tactctctgt gtcagctcga 223861 tgatgtggta ttcgtaggcg cttaattttt tcatgaatat cgagtatccg ccaaacacga 223921 gagcagcccc ggctgccatg atgtctccga gcggatttag acgcagtacc acattgccgt 223981 taaacgtaat caataaaagc ccgatcagtg ccgagataaa tccaatcaaa aaagtcagac 224041 gcaatttttc gccttcgagc agaaaatggg ccaaaaccgc agtgatcatc ggtataatgg 224101 acacgatcat gccgacattg gaggcgtatg tataggtgag agctatattt tctaatagaa 224161 agtataaggt tacgccaaat aaaccagctc cggcaaacaa cagctcctgc cgccaatttc 224221 tgaacggaat catgttggga cggacgagga taagagcgat aaagcccatc aaaaaccgat 224281 aaaataatat ttccattgga gagaagtcag ccagcagaac ttttgtcgaa ataaaggtcg 224341 tcccccaaat cagaatggtc acaatggctg cgatatgccc cgaagtttct ctttgtatgt 224401 tcatctgtga agctcctttt caaaaatctt catgtattgc ttcggcgtca gccccacctg 224461 ccgtttaaaa aacttcgtca tatgactctg atcgctgaat cctgtctgaa atgccgcatc 224521 aatcggcctt accccttgtt caaggagttt tttggcttga ttaatccgga ttgtttccat 224581 gtagctatta ggggtaatgc ctttttgttt tgtaaatgaa cgcaataaat gatacttgct 224641 ccagcctgtt aattcactca aatcattgag tgtaacattt tcggcataat gctcttctaa 224701 aaattcacaa accattttga cttcgtctga tggttctgga acgctgctaa ggaacgtgac 224761 atctgaataa tggcggatca gctcctctaa tagatgaaga aacagctcct ccttacgcaa 224821 agcttgtttt tcctcggata tcaaaatatg caattcctgc aggctggctg tcagctcatg 224881 gcggaataac acatgctggg agaaataagg gagatgcccg gagccagtaa tctctttcac 224941 cgccttctcc atgatatccg gcatgacatt gatacaccga taatcaagcg tccggccgtc 225001 aatctgttca cagctatgcg tgtcacgggg gttaaagagg agaagatcac ctggattgat 225061 gatatattct tgatcctgac aggccagata ccgttgccct ttttcaataa atccaatcac 225121 ataataatcg tgaaagtggt tcgggaactt ctgcataatt cccttgaagc ggtaggcttc 225181 tatatgaagg tgtgggtcaa gctgcagtgt gcgggtttcg ttttgcatgg gatgcctcct 225241 gtcggtgtgg tggtcttgga ttaagtgtag catgattttg ggggatttct tgtatgatgt 225301 tgctgtttag gaatagagaa agcagaccgt tatttgtctg ctttcgttta agaatttaaa 225361 agattttaac cctcaataat aattttatct tttttaataa aaatttattt ttcaaatatt 225421 tcagttataa tggtttggaa cagataggag gggcaaagat gtatcaatca aagaaggttt 225481 tattgttagg ttcaggtgaa ttaggtaaag aggtagtgat tgaagcccag cgtcttgggg 225541 tacagacggt ggcagttgac agttacgagc atgctccggc gatgcaggtc gcgcataaca 225601 gttatgtcgt tgatatgctg gacccagagc agatcagaac catcattgag aaagaaaatc 225661 cggatttgat tgtgcctgag gttgaggcga ttgcgacgga tgaattgctg aagcttgaag 225721 aggaaggatt tcacgttatc ccgaatgccc gtgcggccaa gctgacgatg gatcgggaag 225781 gcatcagacg acttgcggcg gaaacgcttg gacttgcgac agctggctat gaatttgcga 225841 atacatatga tgaatttata caagcggcag ctcagatcgg ttttccttgt gtcgttaaac 225901 cattgatgag ttcttctgga aaaggccaaa gtgtgtgccg ctctgaagcg gatttagaga 225961 gctgctggga gacggcgatg gaaggcggac gggtgaaaaa cggccgcgtg atcgttgagg 226021 agtttatccc tttcgaatca gaaatcacac tcttaaccgt acgtgcggtt aacggtacgg 226081 cattttgtga gccgatcggt catgtgcaaa aggacgggga ttatatcgaa tcgtggcagc 226141 cgcatgatat gacagagcag caaatagaag aagcgaagca tattgcgaaa acgatcacgg 226201 atgagcttgg cggatacggc ctgtttggtg ttgagctgtt ccttgcgaaa gatagggtat 226261 atttcagtga ggtatctcct cgtccgcatg atacgggtct tgtcacgctg gtgacgcaaa 226321 atttgtcaga atttgcgctg catgtccggg cgattctcgg ctttccgatt acagaaatca 226381 cacagctttc tcctggcgcc agcaggcccc tcaaagcgcc ggaagaatta gcggattaca 226441 ctgttgaagg attggaaaac gcactggcag tcccaaagac tcaagtgcgc gtctttggaa 226501 agccgataac aaaagccgga cgtcgtatgg cagttgcgct ttctgctgct gattcagttg 226561 aaacggcaag agagaatgca aagaaagcgt tggaccagct aattttaaaa tagagtttga 226621 acaggtcttg tcatgggaca aggcctgttt ttttctttct ccgtaaaagt tttatcataa 226681 gaatcagaaa cctgattata atgtaaaagt cttccatcga tacgggtggt tgacactaaa 226741 ggagggagat gacaaaatga aattagttcc aagattcaga aaacaatggt tcgcttactt 226801 aacggttttg tgtttggctt tggcagcagc ggtttctttt ggcgtaccgg caaaagcggc 226861 agagaacccg caaacttctg tatcgaatac cggtaaagaa gctgatgcta cgaaaaacca 226921 aacgtcaaaa gcagatcagg tttccgcccc ttatgaggga accggaaaaa caagtaaatc 226981 gttatacggc ggccaaacgg aactggaaaa aaacattcaa accttacagc cttcgagcat 227041 tatcggaact gatgaacgca ccagaatctc cagcacgaca tcttttccat atagagcaac 227101 cgttcaactg tcaatcaagt atcccaacac ttcaagcact tatggatgta ccggattttt 227161 agtcaatcca aatacagtcg tcacggctgg acattgtgtg tacagccagg atcatggatg 227221 ggcttcgacg ataaccgccg cgccgggccg caatggttcg tcatatccgt acggtactta 227281 ttcaggcacg atgttttact ccgtcaaagg atggacggaa agcaaagaca ccaactatga 227341 ttacggagct attaaattaa acggttctcc tggaaacacg gttggctggt acggctaccg 227401 gactacaaac agcagcagtc ccgtgggcct ttcctcgtca gtgacaggat tcccatgtga 227461 caaaaccttt ggcacgatgt ggtctgatac aaagccgatt cgctccgctg aaacgtataa 227521 gctgacctat acaaccgata cgtacggctg ccaaagcggc tcgcctgttt atcgaaacta 227581 cagtgataca gggcagacag ctattgccat tcacacgaac ggaggatcgt catataactt 227641 gggaacaagg gtgacgaacg atgtattcaa caatattcaa tattgggcaa atcaataaat 227701 acagcaaact agccatattc atgtctattt tgtttttatg cgggtgcagt tcgcagacgc 227761 attcttctca aaaagaaacg actattcctg tcactcttca tgtggaggat gctaaggggc 227821 tgccggtcga aggggttcaa gtgacgattg tcaaagcgcc ctcttcagat gaggagccga 227881 gtacagagat tggcgagata ctcggtaaaa cagacaaaaa cggagatatc aaatgggata 227941 ccggcagaaa aggcgattac tcagtcgcgt tgacgaaggg tgaaacatca gtaacccatc 228001 acatctcgtt aacagaggat aaaaaagatc atgccattcc attagtcttc aaagaatagc 228061 agtttccttg attttaaggg aactgccttt tttatttatt gcaggaaacc aaactatata 228121 ctggaaattt attatgtgag ataataagaa ataggtattt tttcttacga gacaaaaggg 228181 gcgttatcct ttatatcaat caaacccgga ggaaaaagaa gaagatgata caagattcaa 228241 tgcagtttgc cgcggttgaa agtggtctgc gcttttacca ggcatatgat caaagccttt 228301 ctttgtggcc gattgagtcg gaagcattct atgtttctac tcgttttgga aaaacacata 228361 tcattgcaag tgggccaaag gacgcacctt cgctcatttt gcttcacgga ggccttttca 228421 gctctgcgat gtggtatccg aatatcgcag cgtggagcag tcaatttcgt acatatgcgg 228481 tcgatataat aggagacaaa aataaaagta taccatcagc agccatggaa acgagagctg 228541 attttgcaga atggatgaaa gatgtctttg attctcttgg acttgagacg gcacatctgg 228601 ccggcctttc gcttggcggg tcccatatcg tgaatttctt actccgcgcg cctgaaagag 228661 tagagcgggc ggttgttatc agtcccgctg aagcgtttat ttcatttcat ccggatgtct 228721 ataaatacgc tgcagagctt acaggggcaa gaggagctga atcatatatc aagtggatca 228781 caggcgacag ttatgatctg catcctttac tgcaaagaca aattgtggcg ggcgtggaat 228841 ggcaggatga gcaaaggagc ctgaagccga cagaaaacgg ctttccgtac gtgttcacag 228901 accaggaatt gaaatcaata caagtcccgg tacttctgat gttcggtgag cacgaggcta 228961 tgtaccatca gcaaatggcc tttgagcggg cttcggtatt ggtgccggga attcaggctg 229021 aaatcgtaaa gaacgccgga catctgttat ctctggagca gccagagtac gtcaatcaac 229081 gcgtcttgtc ctttttatgc ggggggataa aatagtaagg aacatgaaaa gattggcatt 229141 catttttcaa aaggtaacaa atgttgtata ataatagaat ttgaatgctg ctttttttgg 229201 gagcattcta tgttatcatg cttattggag aaaaattttt cctgtaacgc tattcgatca 229261 ctatcgtcaa ataatataga tggttttaca attggaggtt tggttacact gtgaattaca 229321 tcccctgtat gattacgata ggaaacttca tttgcggatt gctggcgatt cattccttgc 229381 tatatcacaa cattcattca gcagtgcttt ttatttttac aggcatgttc cttgatttct 229441 ttgacgggat ggctgctcgt aagctgaatg ccgtttctga tatggggaga gaactggatt 229501 cgtttgccga tctggttacg tttggggtgg ctccttctat gcttgcttac agtgtcgcgt 229561 tgtataccct gccatttatc gggatcttat gcgcattgac gtacagcatt tgcggaatgc 229621 ttcgcctctc taaatttaac attgaacaaa gcaagctccc gacgtttatc ggtatgccga 229681 ttccgtttgc gggcatgtgt ctcgttattc taagcttcac ctataacccg atccttctgg 229741 caatcggcac ttgcggactc tcatatttga tggtgagtaa aataaaattc cctcatttta 229801 aaaaacatgc ggcagaaaac ctggagtctg ggagatggaa ttagttcagc agctcatagc 229861 ggattacggt tatctcgcta tttttttgat gctggtatta ggaattgtag gattgccgat 229921 tccagatgaa gtgatgatga ccgttgttgg ctatttcacg cataccgatg tattgaatta 229981 tgagctttcg atattgatta gttttgtcgg ggctttgtta ggtatgctga tcagctacat 230041 gattggcaga aaagccggac gcccgtttat cgacaagtac ggcaagtggg tcggcttaaa 230101 agaaaaaaga atgatgaaag tggaaaaatg gatgaagaaa tacggtccat attctcttat 230161 tttaggttat tttattcccg gcgtcagaca tgtgacgtgc tacttttcgg ggatcggcaa 230221 aatggatctg aaaacgtatg ttgcgtttgc tgcaatcggc gcctttttat ggtgctttgt 230281 ttttattaca atcggaaggg ttatagggat tattcatgtt taatacggct gtaaagattc 230341 tgtatcgatc attgatagag ctgacgaatc atcgtctgtc atcctatctg attaaaggat 230401 tttgcgagtc gaaaatcagc aaaccggtca ttccgctttt ctcaaaacat tttcggctga 230461 attgggatga tgtggacggt acggctgctg attacggatc gctgtccgaa ttgttcattc 230521 gacaaataaa tctggagcgg cgccctgtgt caaaagaggc gcatgcggtg gtcagccctg 230581 ttgacggtgt ggttcagacg gtaggaatca tcaacccgaa tcaaaccttt acggtgaagg 230641 gaaaagatta ctcattcgct gagctgaccg gctgtaaaag cgcagaccat caatacaacg 230701 gcggatattt cgtcgtgctg tatttaagcc cgaggcatta tcaccgtttc cattctccga 230761 tcagctgcag gtatcaaaag ctggccgagc tcggaaatcg ctcatacccg gtaaatcaac 230821 taggcttaaa atacgggaaa gatgtgctgt cgaaaaatta tcggtttgtg tacgagctga 230881 atagcggcag ccgaaatgtc ctgatgattc ctgtcggcgc gatgaatatt aattctatcg 230941 tgcagacgaa tacccgtact gaattggaga tcggcgagga gctgggatac ttttcatttg 231001 gctcaaccgt cattttggtt tttgaaaaag acgcgttcca gccgtccgcc catttagcag 231061 aaggccaaga agtccaagtc ggagaactga taggttacga agaataaaaa gaggagcttg 231121 cataaacgca gcgcctcttt ttttgaagaa aggtgagatt catggagaaa caaatcatca 231181 gctggattac agattatcag aacaccggag atgaagccgt cctgcggcaa gtgcgagaag 231241 tgtgctggcc gatcgttgaa gcggttttgc aagagaaagt aatggatgat gaacaagcga 231301 acaatttgcg cgaaaaagga atcgagcggt ttccattcat catcagcaaa taccaagcgg 231361 atgtgcagct tccggttgag acatttttac aaaatacgta tcggttttac tttcatcagg 231421 tgatgagaga atccagctaa agcttctttc aacagagaag cttttttttg ttggcaggaa 231481 aaggaaactt tttctatatc tatctcgtaa tgactagaga acctagcaga aaaggagaga 231541 tagaattgaa acgaatgata gtgagaatga ccctgccgct gctgatcgtt tgtctggcgt 231601 tttcttcttt ttcagcctca gcccgtgctg cttctgaaga aaaatattgg gatcactgga 231661 ttgaacgaca tgcacagcct ctggatgctt ccaatgcttc aaacaaagac cttcgatttc 231721 taaaaaaggt gctgaaggga aaacgaatcg ttcagttagg agaaaccaca cacggtgctg 231781 gcgaaatcaa tgccacaaag gtcagaatga tcaaatacct ccacgaagag ctgggatacg 231841 atgtattggc ctttgaatcc ggctttcctg atacaaatgc atcctacctt aatatggacc 231901 aattaacccc taaaagcacg atgaaaaact ccatttacgc tgtatggcac acagaagatg 231961 tcgtcgaatt gtttgattac atgaaagagc aaaaagagaa aggcgatccg ctgatcctta 232021 ccggttttga tattcaaagc atgaagaatt cattcaatgt agctgcgact caatgggtaa 232081 aagcggtgga ccctgagaaa gcagagttgc tctcccaatc agaaaatgat ttttcaacat 232141 tagtgacaga cagcaatacg tttgatgaat tttcgcaaaa gaaggaaaag cttgtgaaaa 232201 actatcagaa gctgatcaag ttcactaaaa cacatgcttc agagctaaaa gaaaaccttc 232261 caaaagagcc gaaagcttat gagatgttta tgcattctct tcagctgaga attgacgtaa 232321 tggaaacata tatgctggaa gaaatgaaag aaaaactaga ggagtatccg gagaatattg 232381 aggatttttc attctttatg agagaccgca tgatggctga acaatttcag tgggtagccg 232441 acacccttta tccgaaaaag aaaatcattg tctggggcca caattaccat ctacgcaaac 232501 agaatacgaa gatgataaag gactgggtac agctaaacgg ccctaacatg ggtgattatt 232561 tgccggagcg gctgaaaaaa caaacatata cgattggcat ttatgcttac tcaggtgcga 232621 gtcttgatag ctccgataat aagactgtta agccggttac aagcccgccg ccgtctggga 232681 gccttgaagc tttgctgaaa gcggcggacc gaccggctgt ttttgttgat tttctccata 232741 caaaaaacaa gaaaggcact tcgtggatgt ataccccgcg gactgcgctc tattgggggt 232801 acatggaaga gcagatgatc ctgaaggaac aatatgacgg tgtcatttgg ctggagcata 232861 tcacgccctc tgtcattatc aagtgagcgg tgtcccctgt ggtaaacagg ggatttttac 232921 atatcgcaaa aataatcaaa acatataatc cgtgatccat tattctaaaa cagaaaggag 232981 attggagcgt gcaatgtatt atgaaaaagc tgtccagaaa acaatcaatt ggattgaatc 233041 acatttacat gagcaaatat caaacgagga tattgttaac gtttcaagct tttcaaaatt 233101 ccattttcat cggatttttc aaaaagaagt cggcatgtcg gttgcttctt atattcggtt 233161 aagacgtctt gcgaatgcgg cggcagcttt gctttataca gatcatcgta ttatcgatat 233221 tgctttgtat tatcagtttg aatctcaaga agcatttacg aggacgttca aaaagatgta 233281 tcacatgccg ccaggagcat accgaacatt tatgaaacgc tttacttcaa aaaaggagga 233341 atcttacatg gagaaaaaaa tgaaaggctg ggtattgagc gggagccatc cgttccaatt 233401 cgaaatgggg attgaccggg aaaatgtaca tcagggaaaa gcttcagggt atttaaagtc 233461 aacgatggtt caggatatcg gtgaatttgc gacgatgatg cagcaattca aagcagatcg 233521 ctatctagga aaaaggcttc gtctatcaag ttttatcaaa acaaaggggg tgcagcattt 233581 tgcctcactt tggatgcggg ttgacagtgc tgctgatgat gttctccaat ttgataatat 233641 gagcaacaga cctattaccg gaacaaccaa ttggaatcat tatgctatcg ttttagatgt 233701 cccagaaaat agcgctgtga tatcttttgg cgttcaatta tctgggccgg gtcaggtgtg 233761 gatggatcat gttgtttttg aagaggtaga tgagagcgtt ccttcaacaa accttgaaat 233821 gccgggagaa cttttagatg aaccggtaaa tttatctttt gaagaggaac tacaaaaata 233881 gttttcagac aactactttt attagtgagt taatggaaaa tactatttgt tattaataaa 233941 cccttgtgct gcttaggttt gtaagagctt ggatattttt atcagtctgg gcggatctgt 234001 tcatctttgc ggcattttcc tgtatgatat agtaagagtg tgcatagcaa ctaactataa 234061 ttgaacaggg tgtttaaaac atggaaaaac aatacagagt attactttac tataaatatg 234121 ttccgattga agatccagag gcgtttagag agcagcatct ggctttttgt aaggagcttg 234181 gtttgttagg ccgtatcctt gtttcttctg aaggaattaa cggtacggta tcaggtacgg 234241 ttgaacagac tgaaaaatat atggaaacaa tgaaagctga tcctcgcttt gcggacatgg 234301 tatttaaaat tgatgaagca gaaggccatg ccttcaaaaa aatcttcgtc cgccataaaa 234361 aagagcttgt aacgcttcgt cttgaagatg atgtcgatcc gaacgaaaca acaggccagc 234421 atttgaagcc tgcagaattt tatgagaaga tgcaggatcc aaacacaatt gtcatcgacg 234481 cgcgtaacga ttacgagtat gaccttggcc atttcagagg tgcggtccgt cctgacatcg 234541 aagccttccg tgaattacct gaatggattg aagagcacaa agatatgctt gaaggcaaaa 234601 agattttaac gtactgtaca ggcggcgtgc gctgtgaaaa gttctcagga tggctggtga 234661 agcaaggctt tgaagatgta gctcagcttg atggcggaat cgtgacatac ggaaaagatc 234721 cagaggtgca aggcaagctt tgggacggcc agtgctacgt atttgatgaa agaatcagcg 234781 tgcctgtcaa ccgtgtcgag catgtgattg tcggcaagga ctactttaca ggagaaccgt 234841 gtgagcgtta tgtgaactgc gcaaatccat cttgcaataa aaaaatgata tgcacaccgg 234901 aaaatgagta taaatatatg cgcagctgca gccacgaatg ccgcacgaac ccaagaaacc 234961 tgtatgtgaa agagcataat atgacagaag aagaagtaaa cgcaagactg gcagcgattg 235021 aaacagaaga tcacgctgct gctgaataaa aaaagaacac ctcgtattga ggtgttcttt 235081 ttttctatat gctttcagtt tggctgtttg cggaaaccca ttctttttgg cggaaggcct 235141 tttcccattt tgataccacg atacaggcga tcgcatgtcc cggtacgttc acgcctgttc 235201 tcgccatgtc catgacgcgg tcaacacccg cgataatggc aacgccttca gccggcagtc 235261 ctacagcatt ggcagtcgcc agaagaacta caagcgatcc tgagggtaca gctgcaatgc 235321 ctttactggt catcacaagc acaagcatca tgagcagctg ctgggacaat gtcatgtcta 235381 cttgaaaggc ctgtgcgaga aagatacaag aaaccgataa atataagctg gagccgtcac 235441 agttcaatga caagccggag ggaacgacaa atgataccac tcgtttggga cagccgtatt 235501 tctccattct atccatcagc tgagggagaa tggtttcagt gcttgtggtg gaaaatgcaa 235561 ttaaaaacag atcccatatc attttcaata cttcgaaata cttaatctga aagatgagac 235621 cgacaagcgg aaagaggaca aagaggatca ggaacaggcc aaggaatacg gtgccaacca 235681 gcttaaacat agggaggagg agttcaatgc catattggcc tacagaagca gccatcaggg 235741 ctaacacgcc gataggagca gtgaccatga cgatttgcgt gagcttgaac ataatctgag 235801 ctgtagattc aaaaaacttc attactggtt cagaagcttt gccgatacca gctgcggcga 235861 caccaaataa aatggcgaag aaaataacgg caagcaaatc atttctggcc atgacatcaa 235921 taatgtttgt agggataata tccaggatca tttgcttgaa atcaacaact ttgtctgtgt 235981 agccggaaag ttcatgaata tctttttttg ccaaatggga gaggtcaagc ccgacacctg 236041 gttttaagac attcgctaat aaaagtccaa gccctaatac caacgttgta atcacttcga 236101 accaaatgat cgtcttgatg ccgagactgc ccattttttt catgcttccg cttcctgcgg 236161 ctccaatgac aatggtagaa aatacaatcg gcacaacaat cattttaatc aggcggataa 236221 atccatctcc gacaggcctc agtgccatcc cgaaatcagg aaaaaagtgg ccgatcaccg 236281 cgccgacagc caaagcgatt aaaatttgaa acgcgattaa ttttttcaaa tgaatccccc 236341 tttagaacga tagaatgtag gcatattcat atcattcgtg attcaaatgc aaacaccttt 236401 tttcaagtta ttttattttg acagcgcttt cattatgttg gcgaaaaagt cccccgcagc 236461 aggggggact tttttacttc atttgaatgt gctttagatc ttcttcagag gtatttgtga 236521 aaataaccgg tgttatggct gaagcggcat gctgcttgat gtaattgaga tcaaaggtga 236581 gaagcagttc gccttgtttg acggcttgtc cgcttgtgac atgtgcttca aagccttccc 236641 cattcagttt gacggtatcg atgccgacat gaatcaggat ttcagtgccg ccggcgctca 236701 taaagccgat ggcgtgtttt gtcggaaaaa tcgagacgat ctcgccgtcc gcaggtgcaa 236761 cgacttttcc ttctgatggt ataatcgcaa atccctcgcc catcattttt tctgaaaaga 236821 cctgatcagg cacatcccct aaagagactg tttctccttt aatcggataa ataaaggtct 236881 catcggaatc gggcttcagc ggtttgtcag ttaccgtgtc cagcgcggcg gcggtggcag 236941 ggacgcctcc ggccatgatt gttttgatgt cgtcttttaa ggcatcggac ttggttccga 237001 atattgcctg gaagttgttg ttgacctcca gcacacctac tgcaccaagc cgttttaatt 237061 catccttgca gacttggctt ggctgatgaa cggtcacacg aagccttgtg atacatgcat 237121 ccaggttagc gatattttgc tgtccgccca aggcctgcag cacgtgaaag gcaagctggt 237181 cttttgcaac tggagctttc tcctcattct gaccgtcttc atctgtctca cggccgggcg 237241 ttttcaaatt ccatttcaga atcgcaaatc ggaacaaata ataataaatg aaagcaaaca 237301 cgatcccgac aggaatgaca acccagccgt ttgtagacag tccgtagttc aagacgtagt 237361 caattcctcc gcctgagaac gtatagccgt ggcggacatg gaataaatca caaacgacaa 237421 agatgacgcc ggcaagaata gagttaatca aatagagcac gggcgcaacg aacaagaaag 237481 aaaactcaac cggttctgta attccggtca gcatagatgt gagcgccgca gaaatcatca 237541 cgccggagat catttttttc ttttccggac gcgcggtatg gataatggca agagcaacgg 237601 ccggcagaca gaaaatcatg taagggaaat cccccatcat aaagcgcccg gctgtcgggt 237661 ctcccgcgaa aaaccttgtc aggtcgccgg ttacggtgtt gcctgttgat gggtctgtgt 237721 attctcccat cataaaatag aaaggcgtat aaaaaatatg atgcaggcca aaaggaatca 237781 gcaaacgata gatcgttgca taaaagaaca ggccgactgt tgaatcggca attaaactgc 237841 tggctgcgtt aattccgttt tggatcagcg gccaaacgaa tgagaaaatg acgccgatca 237901 ccaatgaact gacggaagta atgatcggga caaagcgttt tccagagaaa aatccaagga 237961 ccggatgcag ctcgattgat gaaaatcgct tatataaata ggcggcgaga agcccgataa 238021 tgattcctcc gaaaaccccc atatcaatca ggtgctcggc tccttcatac ggaggctgaa 238081 ggccgagtaa ttttcccata ttgtcgaggg tgacggttaa aattaagtat ccgatgacag 238141 cggcaagtcc ggctacacct tctccgccgg ctaatccgat cgcgaccccc acggcgaaaa 238201 tcagcggaag gttatcgaat acaacgccgc ccgcatcctt tataataggg atgttcagta 238261 aatccttgtc tccgaaacgg agcaaaagac ctgctgccgg caggacggca accggagtca 238321 tcaacgcgcg gccaagctgc tgcagaattt gaaatgcctt tttaaacatg acagtctcct 238381 tttattgtgt tatgagaatg atgcactctt taatttttga gctgctttat aatcggcgat 238441 aacggttaca tgattgtgtt tttgaagaat ggaggctggt acatctgtcg tgacaggacc 238501 ttcagccatc ttttgaatgg cgtctgcttt ttcctcgccg cttgctaaaa gcacaatatg 238561 tttgctgaat tccatgatgg ttttaatgcc cattgaaatc gcgagtctcg gaaccagcac 238621 cggatcgccg ccgaagaatc tggcatttgc ctgtatcgtg ctttccgaga gcttcacaac 238681 acgtgtccgg tcttcaaaat cagatcccgg ttcattaaaa ccgatatggc cattggcgcc 238741 gatgccgaga atttggacat caatgcctcc cgcctggcgg atgagatcct cgtatacttt 238801 gcatgccgcc tcaagctgcg gattgtctcc ttgcgggata tgaatatgat caggctgcat 238861 attgatatgc tgaaaaagat gctcatgcat aaaatggtta taactttgcg gatgagatgg 238921 agagagacca gcatattcat ccaaattaaa tgtagtaacc tttgaaaaat caatttcgcc 238981 tgcctgatag tctgaaatca actgcttata caagccgacc ggtgtgcttc ctgttgccag 239041 gccgagaacg gcatctttct tagcttgtat ttgttcttta ataatggcag cgcttaactt 239101 acagagttct tcgtagtgct cggcgatcag aatcttcatg tgacaccccc tcaaagagat 239161 agacaagcac catatttgtt atgaccaatt tatgatactt gtcattacga atttagcacc 239221 gcccttatca aactgtcaat attaatttct gaaaatttgt tataaaagaa ggatacaaat 239281 ctttcatatt gggagggcaa atggtattat ggtctcaatg aaaaagaacg gattgcatac 239341 agaatgggga gaatgaaatg acagctttat attctgttat caagtttaaa atcattgagt 239401 taattaaatc gggcaaatat caggcgaatg atcagctgcc gacggagagt gagttttgcg 239461 aacaatatga tgtcagcaga acaactgtga gactggctct gcagcagcta gagcttgagg 239521 gatatattaa aagaattcaa ggaaaaggga catttgtatc ggcggccaaa atacaaacgc 239581 cgattccgca taagattacg agctttgcag aacaaatgag aggacttcgt tctgaatcaa 239641 aagtgcttga gcttgtggtg attcctgccg atcattccat cgccgagctt ttgaaaatga 239701 aagagaatga acctgtcaac aagcttgtca gagtcagata cgccgagggg gaacctttgc 239761 agtatcatac ctcatatatt ccctggaagg cggcaccggg gctggcgcag gaggaatgca 239821 ccggctcgct gtttgaattg ttaaggacaa aatacaatat tgaaatcagc aggggcacgg 239881 aatcgatcga accgatttta acggatgaaa cgatcagcgg acacttatta accaatgtcg 239941 gagcgcctgc gtttttatca gaatccctta cctatgataa aaatgaagaa gtggtggaat 240001 atgcgcaaat tattacacgg ggagaccgaa cgaaattcac cgtagaacag tcatatcatt 240061 cataaagcaa tgtgttttaa gaagggaatg gtggttctat gtttttattt acgaatggaa 240121 aagtgctgtg gggagcagtg attgctgcat tcatcctttc aattgtattt tacccttttc 240181 tgccgacgca gatgccgatt cattatgatg ttgcgaacag tccggatctg acggttaaca 240241 agctggcggg gactgtgatg ctgcctgttt tgatggtggt gtttgcatgg gcgcggaaga 240301 tcaattggca atttgtattc gcagtgtata ttttgctgat ttgccacatt gtcgtccttt 240361 gtttagcgct ctaaatcaaa cagccagaat aaaactggct gttttcttta atttcagctt 240421 catctgacaa tgaatgtggt gtataatagc tgatgatcct aaagaatatt ctgaaattta 240481 taggtgtgaa gcggcgtatt attaaaggaa aggctgtata ctttttgcag ctttaaaaag 240541 actgaatatt taaacaatta tgtgaaaggt gtgctgatta gattgaataa gcttattgaa 240601 cgagaaaaaa ctgtatatta taaggaaaag cccgacccgt cttccttggg gtttggacaa 240661 tattttacag attatatgtt tgtgatggac tacgaagagg ggattggatg gcatcatccg 240721 agaattgcgc cgtacgcacc gcttacgctt gatccgtctt catctgtttt tcattacggc 240781 caggctgttt ttgaaggatt aaaagcatac agaacagacg acggcagggt gctgctgttc 240841 cgtccggatc aaaatatcaa acggctgaac agatcgtgtg agcgcatgag catgccccct 240901 ttagacgaag agctggtgct tgaggcattg acgcaattag ttgagctgga gaaagattgg 240961 gttccaaagg aaaaaggaac gtcactgtat attcgtcctt ttgtcattgc cacagaaccg 241021 agtctcggtg tgaaggcatc caggagctat acatttatga tcgtgctttc gcctgtcggc 241081 tcctattatg gcgacgatca gctgaagccg gttagaatct atgtcgaaga tgagtatgtg 241141 agggcggtca acggaggagt cgggtttgca aaaacggctg gaaactatgc cgccagtctt 241201 caggcacagc ggaaagcgaa tgaactgggc tatgaccagg tactgtggct ggacgccatc 241261 gaaaagaaat atgtggaaga agtagggagc atgaacatct ttttcgtcat aaacggggaa 241321 gctgtcacac ctgctttaag cggaagcatt ttaagcgggg ttacacgtgc gtctgcgatt 241381 gaattgattc gaagctgggg cattccggtt cgtgaagaga gaatatcgat tgatgaggtg 241441 tatgcggcct ctgcacgcgg agaattgaca gaggtctttg gcacaggcac ggcagcagtc 241501 gttacgcctg tcggtgaact caacatccat ggaaaaacgg tgattgtagg cgacgggcaa 241561 atcggggacc tctcgaaaaa gctgtatgaa acgataacag atattcagct tggcaaggta 241621 aaaggcccgt ttaactggac agtggaagtg tgaaaatcga aaaagaacct gcccggaggc 241681 aggttctttt tattttgaat gagtcatatc agcagccggc tggcttttgc ggttttttac 241741 ataatatatt gcatagcaaa tggccataaa tggaacgccg caatagagtg cgattctttg 241801 attcggatca aaggcaatgc caacgacgga agccaggcat aacaggaacg cagcaatcgg 241861 cacgaacgga tacaaagggg ttctgtattt caaatcagta accttgtttc ccgcttcgat 241921 ataacgtttt ctgaacatga attgagaagc agcgattccc atccacacga caacgacggc 241981 aaaaccggaa atcgacacga gcacaacgta tacagtgtct ggcgcaaata cgctggacag 242041 caacgacaga atgccgccga tcatgctgaa caccagcgcg ttaaaagggg ttccttttga 242101 cgtcagcttt gcaaatgtcg gatgaagcgt tttttctttt gataaagacc acagcatccg 242161 ggaagaagcg tagagtccgg aattagccgc tgacaggatc gctgtcagga taacaaagtt 242221 catgatatcg gctgcgtatg gtacaccgac tctgtcaaag acagcgacaa acgggctttt 242281 gatgacacct gcatcttgaa tcggaatcag ccctgacagc acaaaaattg ttccgacaaa 242341 gaagagcgag agacgccaga ccgttgtttt tatcgctttt ggtatcgtct tgtcaggatc 242401 aacgctttca ccggctgcga ttccgattag ttccgttccc gaaaaggcaa aattgacgga 242461 cagcatcgtc atcaaaatcg ggacaaatcc attgggaaaa agcccgcctt ccgccgtgaa 242521 gttggacagc atcggagcgg cttctccgcc tttgatcggg atgatgccga acatggcaga 242581 gccgcctaaa agaataaata atacaatggc taatactttg atgctggaaa accaaaattc 242641 tgattcagcg aaaaacttga ccgaaaatgc gttaagcaag aagatgaaca gcgcaaagac 242701 ggcactccac atccaaaccg atgtatgggg gaaccagcgc tgcattaaca ggccggctgc 242761 tgtgaattct gatcccaatg ccacggtcca tgtcagccaa tacagccaag cgaccgtaaa 242821 tccggtgccc ggccctatgt atttggctgc ataggtgtga aaggcgccgg tcacaggcat 242881 ggcgactgac agctcaccga ggcatagcat gaccagatag acgatgccgg ccccgactaa 242941 gtaggcgagt atcgttccgg ccgggcctgc ttgctgaatg gtataacctg agcttaaaaa 243001 cagcccggtt ccgatgacac ctcccaagga aagcataaag aggtgccggc ttttcatact 243061 tctctgaaag gttgtctcat tcttgttgtg ggcagagttc atctttttcc aactttctat 243121 cagcgattta tttccttcct aataaaaaat ctcatgtcag aaagtgacac gagactccgg 243181 cgaaccggct ttaagttaga atatacaaac tattccgata agtcaagttg tttttaaaga 243241 gcgggcccaa gccgcaattt cttgaatatt ttcgggtttt gtccggcagc agccgccaat 243301 cagcctcgct cctttttcat gccaggtgcg ggcgctcgcc ccgtaagatt ctgcgcatgc 243361 tgcgccgttc cacgtttttg tttccggatc atattgctca cctgaattcg ggtagacaat 243421 gatcggtttt gacgtgttct tttttaactc ctctatcaag gaagggatat gctgaagcgg 243481 cgtgcagttg atgccgagtg ctgcaatttg gcggtgttca tcaagccacg atgcgcagtc 243541 agctgcaggt gttccgtcac tgatatgcaa gccgtcttta gcactgaagc tgatccatgc 243601 atacgtttca ggaaattcct tcaacagccg aacaatcgct ttggcttcag tcagacacgg 243661 aatcgtttcg catgccaata catcagctcc ggcttcaatc agcgccttca tccgggggcg 243721 atgaaattca atcagttcat cttctgatat tgcgtagttg ccgcgatact cagacccgtc 243781 tgcaagataa gcgccataag ggcctataga agccgcaatg atcggttttg gccgattcaa 243841 acggttctct tcaagcgacc aaaattcatc acgtgcttca gctgcgatgc tgacggacaa 243901 ctcgatgagc cggcgtgctt ccgcttcgct cagcccgcgt gcggcaaagc cttcaaatgt 243961 agactgatag ctggcggtga ttgcacaatc ggcgcctgcc gcaaaataat cagtatgaac 244021 ttgtttaatc agctccggct cttccatcag gatttttgcc gaccacagac tgtcattcaa 244081 attacagccc ttgcgttcaa gctcggtcgc catggcgccg tctagcacaa taagcgggta 244141 tgtatctaat atgtgttgga taggattcat agaatgtacc gatgccttct ttcagatttt 244201 tttgaaaaag atatgaaaat cgtaatggag gcttacgtgt ttgtcaataa acgcaaaaag 244261 agaaaggtgt tcagcccata tgtctgaaca cccttttctt atgatatttg tttgttgtgc 244321 gtgtcagtct ttgtgtctga aaccggccag cactcaatgc cattatggtt tttgagcaca 244381 tctttataaa agaccggatc cttgcctgct tttttctggc gtgtatagtc tttcagcgcc 244441 gtaaaaacga cctttgatag taagaaaatc gcgattaaat tcacgatgac catcaaaccc 244501 atgaacaaat cagcaagatc ccagacgagc tggactttgg caacacagcc aaacacgatc 244561 attgccagca cgccgatacg gtagacaaaa atcagttttt tgcttttgtt caaaaagccg 244621 atattggttt cgccataata atagtttcca attagagcac agaatccgaa taacaaaatc 244681 agaatcgcga gaaagcctga tgcccatgat ccgacatggg agctgaggga ggcttgtgtc 244741 aaggcgattc cgctcagacc cggagtatga taggcatccg aaaacagaat gataaaagcg 244801 gtgcttgtac aaatgaccag tgtatctgtc agtacaccaa aagcttggat cagcccctgt 244861 ttgacgggat ggcttgttgt ggcggtggca gcggcatttg gtgcgcttcc cattcccgct 244921 tcgtttgaaa agattccccg tctgacgcct tgcatgagtg ccgcgcccaa agccccgccg 244981 gcggcctggt caaaaccaaa cgcatttttc acgattagcg caagcacacc tggcagctgc 245041 gtaatgttgg agaaaatgac gaaaaacgca actccgatat acaggacagc caatacgacg 245101 acaatggatt cagccagctt tgcaatgcgc ttgactccgc caaaaataat cgtgccgaat 245161 acagcaatta aaatgagtcc caatgtcagg cggtttgtgc caaacgcgtt ttcaaaggca 245221 aggctgactg tattggattg aaccgagttg aagacgatac cgaacgataa ggtgattaac 245281 acagcgaaca gcgcgcccat ccaccttttg ttcagccctt tttccatgta atacgccggc 245341 ccgccgcgga agccgtttac atcttttact ttataaatct gagccagtgt gctttccaca 245401 aagctggatg ctgatccgat aatggcgata atccacatcc agaagattgc accgggcccg 245461 ccgagtgcaa tggcgatagc aatgcccgta atatttcccg ttccgacacg ggccgccatg 245521 ctgatgcaaa aggcttgaaa cggagaaatg ctgttttttg accgggaagc agcaccttct 245581 cttaataccc tgaccatttc tttcagcatg cgaacctgta aaaacttaag cctgaacgta 245641 aaatagattc caaaagaaag gagcaaaaca attaatagct ttgaccacaa aagatcattt 245701 gcaataccga cgatatgttc taggatttgc tgcatagaat cacctctttt ttcatgttta 245761 aaaaatgctg agctcccatt cctgcgccat atgcttcagc agcataccgc cagtgaggct 245821 gttgccgtat tcatcaatgg caggcccgta aatgccgatg ccgcatccgg attgaaaagg 245881 ctgttctctt ctggcgcttg gaggcaccag cgccatgatg ccgccggaga cgccgctttt 245941 ggccggcacg ccgacaaacg ccgcatattt gcctgaagcg ttgtacatgc cgcacgtcag 246001 cattaatgcc ttggccaatt ttgccacatc ttttggaatc acctgctcgt gtcgaatcgg 246061 atgatacccg tcatgagcaa ggatcaggcc gatcaacgca atatcttctg tagtgctctc 246121 catagcgcat tgcttcaagt acacctcaag tgtttcttct acttcagctt ctaaaaagtt 246181 tgtttctttt aaatagtagg ccagcgctct gttgcggtgg gcggtttccc attcagaacg 246241 gaatacttct tcatgaattc ttggccgttt tcctatcaaa gtttccatca ccgagtaaag 246301 aaactcgagc ttttcgtatg cagattctcc gggaaggatc gaagcgatgg tgagggcacc 246361 cgcgttgatc atgggattga agggctttcc cggcttgttg atttcgagcc gaatgattga 246421 attaaaggcg tcacctgtcg gctcgacatc tacgcggtca agcacatagg gaatgccgcg 246481 gctcatgcag gcggcaataa agctaatcac ttttgaaatg ctttgcatgg taaaagagac 246541 gttccagtcg ccggcgtgta tcatcgttcc atcaggctcc aatacacaga tgccgagctg 246601 tgaatcattg acttttccta aagcggggat atagtttgcg ctttgtccat tggcggcaaa 246661 agggcgatag tattcaaccc aatcatgaag ctgtaacgcc gggtttatgt ctttctggtg 246721 ctcttttatc aattctttca tcgaattcct cctcactgat ttttttctta aaggactgag 246781 gtgtatcaaa acgaaggcta agggggcgtt aaacgctttc ataatagcgg aaggtataat 246841 tactgtataa tggagactac agaatcatac aaaatacgac aaaaacattt tgaaaataag 246901 cagtaagatt tataaaaacc tcatgttctg ggtcaaaagc aatttgcagg ttttctcccg 246961 attccccaaa ataaaaagcg aggatgtgat caacataaaa ctggaacggt ttattgaaaa 247021 agacggatat atactggccc tcatgctgat tacggtgccg ctggccggtg aactgaaatt 247081 ttatcccctc aatgaagaat tccgggtcag ctttggggca ccggtttttt tcttcttttt 247141 atcattgttg cggcatgtgc ccgctgtgct gccgggtttt ctgactggag cggctgtttt 247201 catctttcgc gtctttctgg aattatgggg cggaggacac aatgggctga ctccgattct 247261 gtatgatcaa gcgtctggct ttttctttta tatgacttac gcctgtctgt tttccatatt 247321 aaaggccaat cgtttccgtg aacggccgat tatgctcggt ttcattgggt ttatgattga 247381 agttgtgtca gattgtgtcg agctaactgt gcaatttctc atttttcata cggttgtcac 247441 gcctgagaaa atcactgaca ttgcggtgat tgcgatttct cacacattta ttgtgatgag 247501 cttttatagt gtgctgaagc tgtatgaaac acaatcgaga gaaaaacaga caaggcagca 247561 gcacgagcac atgctgatga tcgtttccaa tttatatgaa gaaacggtgc acctaaaaaa 247621 gacattgaaa acgacagaga aagtgacaaa cgattcgtat cagctctatc gggaaatgaa 247681 gggcaaggat gttcagctga gcggcagaat cctgagactg gccggagaga ttcatgaagt 247741 gaaaaaggac aaccagcgga tattcgcagg gctttcaaaa ctgatttcga atgagagttt 247801 gagagattat atgagggctt ctgatttgct gcagctcgtg attcgaatga atgaaaagta 247861 cgctgaagca ctagggaagc agattgattt ttactgctcg atcgagggag agcatgacga 247921 atatcacgta tttatcgtgc tttcgatcat taataatcta acagcaaatg cggtagaggc 247981 tatggatgaa gagggaatgg tcagcctgag gctccgtaag ccaaatgaga gtatggtaga 248041 attccaggtg gaagacaatg gccccgggat ttccgagaaa atcggagaca ttgtgtttga 248101 cccgggcttt acttcaaaat atgacgaatt tggcacgcct tctacgggta tcggactttc 248161 ctacgtaaag gaaatcgtga cagagctaga aggggatatc acgtttgata atcagcagcg 248221 gggagtggtg tttgccatca ggctgcctgt ccggcatttg attcagaaag ggtgaaccaa 248281 aagctatgcg tttttttatt gcagatgatg accgtgcggt gcggtcaatt ttaaggcaga 248341 tcattgagga cgaagatctc ggggaagctg ctggtgaagc agacgacgga agccaagtgg 248401 aagggcatat gctgcaattt aagcagattg atattttatt aatcgatctg ttaatgcccg 248461 gaagagacgg cattgagacg attcgtcaga tccagaatac gtactccggc aaaatcgtaa 248521 tgatctctca agtggaggcg aaggaaatgg tcggggaagc gtactcgctc ggcatcgaat 248581 attttatcca taagccgatt aaccgcattg aaattgtcac ggttctccaa aaggtgaagg 248641 agcggatcga gcttgaacac tcgattggag ccattcagca ttctctaagc cggcttgtca 248701 atcggactga acggaaagcg cgtccccagc agaagagtga cagcggttta aaagaggcag 248761 gaacattcct gttgtccgag ctgggcatga tgggagaagg cggcgcacat gatctcatgg 248821 cggtcctgca gtatttagca gaacacgagc aatccgagcc gcacgaaaaa caaagccctt 248881 cgctaaaaca aatattcacc caagtagcgg tacggaagct ggggacagga gcctcacaga 248941 cggaagtcaa tcgcgaaatg aaagcctcgg agcagcgtat ccgcagagcg attattcatt 249001 cgctgcacca ttttgcttca ctgggcacaa ctgatttttc gaatccaaaa tttgaaacct 249061 atgcatcgaa attctttgat tttccggttg tcagccagaa aatgaaagaa ctccaatcca 249121 aggatgcaaa accccttgca cctgctagaa taaatatgaa aaaattcatc cacgtgtttt 249181 ttttggaagc aaagcttttg catgagacga tgaaacaaag aaggatataa accaaacagc 249241 cggctgacca ggctgttttt ttgctgcgca gaatcccggc cggacagtga tttaccgctt 249301 ttttataaaa tatcagaaaa taaagatatt gacttattgt ttatttgtct tacaattaaa 249361 caaaaggata tatgggaagg agcggatgtg aaagaaaaat taataaaagc gcttacagat 249421 agaggccgta tacacaaata acaggaggtt atgttgatga gccgtatcag aaaagcaccc 249481 gctggaattt taggttttcc ggttgctcct tttaacacac aaggaaaact ggaggaagaa 249541 gctctttttc aaaacattga gtttttgctg aatgagggct tggaagcgat atttatcgct 249601 tgcgggtctg gtgaattcca atctctcagc cagaaggaat atgagcaaat ggtggaagtc 249661 gcagtctcgg cagccggagg aaaggtgccg gtctacacgg gggtgggcgg caacctcagc 249721 acagcgcttg attgggcgca gctgtcggag aaaaaaggcg ccgacggcta cttgattctg 249781 cctccgtatt tggtgcatgg cgaacaggag gggctgtacc agtatgcgaa aacgattatt 249841 gaaagcactg acttgaacgc gattctttat cagcgcgata acgcagttct ctctgttgaa 249901 cagatcaaac gtctgaccga atgtgaacag cttgtcggtg tcaaagacgg ggtaggaaat 249961 atggatttga atatcaatct cgtctatacg atcggcgacc gcttgggatg gctcaacgga 250021 atgccgatgg ctgaagtgac gatgccggct tatctgccga tcgggttcca ctcttactct 250081 tcagcgattt caaattatat cccgcatatt tcgcgaatgt tctatgatgc attgaaaaac 250141 ggaaatgacg agcttgtgaa ggaactctat cggcatgtga ttctgccgat caacgacatt 250201 cgcaaacaac gaaaaggcta cgccgtatcc ttgattaaag ccggtatgga aatcatgggt 250261 ttgaatgtaa ggaatacagc cagaccgcct gtcggcccgg ttgaaaaaga tcattatcag 250321 caattggaag caattttgaa gcaggcggct gaccgttttc cgaaaaaagc cgcgacggtt 250381 tgaccagaaa aaacacgaaa ggggcaatgg gcatgtctgt gatcacggaa caaaacacgt 250441 acctcaactt tattaacgga gagtgggtta agtctcaatc aggcgatatg gtcaaagtcg 250501 aaaaccctgc cgatgtgaat gatattgtcg gatatgtaca gaattcaacg gctgaagatg 250561 tggaacgtgc cgtcaccgcc gccaatgaag ccaaaacggc ttggagaaag ctgacgggtg 250621 ccgagcgcgg ccaatactta tacaaaacag cggatatcat ggagcagcgc ttggaggaaa 250681 tcgccgcctg tgcaacgcgt gaaatgggta aaacattgcc ggaagcgaag ggagaaacag 250741 cccgggggat tgccattctg cgctattacg ccggagaggg catgcgaaaa acgggtgacg 250801 tcattccgtc tactgacaaa gacgcgctca tgtttaccac ccgtgttccg ctcggtgtgg 250861 tcggtgtgat ttctccgtgg aacttcccag tggcgattcc gatttggaaa atggcgccgg 250921 cattggtata cggcaatacc gttgtcatca aaccggcgac agaaacagct gtgacatgcg 250981 cgaagatcat tgcctgcttt gaggaagcgg ggctcccggc aggggtcatc aatttggtga 251041 caggcccggg ttctgttgtc gggcaggggc ttgctgagca tgacggtgta aacgccgtta 251101 cgtttaccgg ttcaaatcaa gtcggaaaaa tcatcgggca agccgcttta gcgaggggag 251161 ccaaatatca gcttgagatg ggcggcaaaa accctgtcat cgtagctgat gacgctgacc 251221 ttgaagctgc ggcagaagct gtcataacgg gggccttccg ttcaaccggc cagaaatgca 251281 ccgcgacaag ccgtgtcatc gtacaaagcg gaatttacga gcgctttaaa gaaaaactgc 251341 tccagcgcac aaaagatatt acaatcggag acagcttaaa agaggatgtc tggatgggac 251401 cgatagccag caagaatcag cttgataact gcctgtcata cattgagaaa ggcaaacagg 251461 agggcgcttc ccttttaata ggaggagaaa agctggagaa cggaaagtat caaaacggct 251521 attatgttca gcctgccatc tttgacaatg tgacatctga gatgacaatt gcccaggagg 251581 aaattttcgg tccggtgatc gccttgatca aggtggactc gatagaggag gcgctgaaca 251641 tcgccaatga tgtgaagttc ggtttaagtg catccatctt cacggaaaac atcggccgaa 251701 tgctttcttt cattgatgaa atcgatgccg ggctggttcg gatcaatgca gaaagcgcag 251761 gtgttgagct gcaggcgcct tttggcggca tgaagcagtc gagctcccac tcccgagaac 251821 agggtgaggc agcgaaggac tttttcacag cgatcaaaac tgtttttgtg aagccgtaat 251881 ggtgctggaa agaggcgtgc gtctctttcc cggtttatca caaccagcat atgattctct 251941 actttgaaaa ggagaagata ctatgaaaaa agactttgcg agtgttactc cggcgggcaa 252001 aaaaacgtcc gtgcgctggt tcatcgtgtt tatgctgttt cttgtgacct ctattaacta 252061 cgcggatcga gcgacgcttt ccatcaccgg agattccgtc cagcacgatt tgggattgga 252121 ctcggtcgcc atgggatatg tcttttctgc ctttggctgg gcctatgtca tcggacagct 252181 tccgggcggc tggctgctgg accgttttgg ttcaaagact atcattgcgt taagcatctt 252241 tttctggtcg ttttttacgt tgctgcaagg ggcgattggc tttttctccg ccggcacagc 252301 gattatcctg ctgtttgcac tgcgttttct ggttggttta tcagaagcgc cttcatttcc 252361 cggaaacggc agagttgttg cctcatggtt tccaagctcc gagcgcggga cagcttcagc 252421 cttttttaat tcagcacaat acttcgcaat cgtcattttt tctcctttaa tgggctggct 252481 tacccactct ttcggctggc attccgtttt cgttgtcatg ggtattgcag gcattcttct 252541 ggctgtcatc tggctaaaaa cggtgtatga accgaaaaaa catccgaagg ttaatgaagc 252601 tgagcttgcg tacatcgaac agggcggcgg gctgatttcc atggatgaca gtaaaagcaa 252661 acaagaaaca gaatcgaaat ggccgtatat caaacagctg ttaacgaacc gcatgctgat 252721 tggcgtgtac atcgcgcaat actgtattac gactctcacc tatttctttc tcacatggtt 252781 tccggtatat ttggttcagg cccgcggcat gtctattctt gaagctgggt ttgtcgcttc 252841 cctgccggcg ctgtgcggat ttgccggcgg cgtgcttggg ggcattgtgt cagacatctt 252901 actcaaaaaa ggccgttcac tgacctttgc aagaaaagtg ccaatcattg ccggcatgct 252961 gctgtcttgc agtatgattg tctgtaacta cacagattca gcatggctcg tcgttgtcat 253021 tatgtcgctc gcgtttttcg gaaaaggctt cggcgcattg ggttgggctg tcgtgtcgga 253081 cacgtctccg aaagaatgtg caggattaag cggcggtttg ttcaacactt tcgggaatat 253141 tgcctcaatt acaacaccga ttattatcgg atacattgtc aatgccactg gatctttcaa 253201 tggcgcgctt gtgtttgtcg gcgctaacgc gattgcggcg atcctcagct atttgctgct 253261 ggtcgggccg atcaaacggg tcgtgttaaa gaaacaagaa caagaccccg atcaatcgtt 253321 gcctgtctaa tatttatgaa agcgctttat aaagggagga aaatgcatga gttcaccgat 253381 acaagagcag gttcaaaaag aaaaaagatc gaatattccc tcaatttctg aaatgaaggt 253441 gattcctgtt gcgggacatg acagcatgct gctgaatcta agcggagcac acagcccgtt 253501 ttttacccgg aatatcgtaa tcttaacaga cagcagcgga aatcagggag tcggcgaggt 253561 gcctggcgga gagcatattc gccgcacact ggagctgtca gagccgcttg ttgtcggaaa 253621 atctatcggt gcgtaccagg cgatattgca aacggtcaga aagcagtttg gcgatcagga 253681 caggggaggg cgaggaaacc agacgtttga tttgcgcacc actgtgcacg ccgtcaccgc 253741 actggaagcg gctttgttgg atttgcttgg aaagtttctt caggaaccgg tcgcggcttt 253801 gctgggcgaa gggaagcagc gtgatgaagt aaaaatgctc ggttacctct tttacatcgg 253861 cgaccgaaat cggacgacct tgccgtatca aagcgatgag cagtcagatt gtgcgtggtt 253921 ccgtctgcgc catgaggaag cgctgacgcc ggaggccatt gtgcgtcttg ccgaatccgc 253981 acaggagcgc tatggctttc aggatttcaa attgaaaggc ggggtgctgc ggggagaaga 254041 ggaaatcgaa gctgttaccg cattatcgaa acgttttcca gaggcaagga tcactcttga 254101 tccgaacggg gcatggtcat tagaggaagc tattgcatta tgcaaaggaa agcaagatgt 254161 gctcgcgtat gcggaagatc catgcgggga tgagaatggc tactccgctc gtgaagtaat 254221 ggctgaattc cgccgcgcga cagggcttcc gactgcgaca aatatgattg cgactgactg 254281 gcgggaaatg ggtcacgcga ttcagctcca cgcggtcgat ataccgctgg ctgatccgca 254341 tttttggacg atgcaagggt cggtgcgggt tgcgcaaatg tgccatgatt ggggtttgac 254401 atggggctcg cactccaaca accactttga tatttccctt gcgatgttta cccatgtggc 254461 agcagcggct ccggggcgga tcacggcgat tgatacccat tggatctggc aggacgggca 254521 gcgattaacg aaacagcctt ttgagatttc ttctggctgt gtcaaggtgc cggataagcc 254581 tggactaggc gtcgatattg atatggaaca agtggaaaaa gcgcatgaga tctatcggaa 254641 aatgaattta ggcgcacgga atgatgcgat cccaatgcag ttcctgatca gcaactggga 254701 atttgaccgg aagcgcccgt gtcttgtgcg ataagtttga ttgtaaatat tgtcatatcc 254761 gctattttgt cttacaattg aacaactgaa gggagagttg ttcgtgtacg aaggtttaga 254821 ggatttgaaa gtcgatacag tcaatcggaa aacattagcc aagcaggtca tcgaacggat 254881 tgtccattta ttatcgagcg gacagttgag ggccggagac aaattgccga cagaaatgga 254941 actgatggac attttgcatg tcagcaggcc ggtgctacgg gaagcactca gttcacttga 255001 aacgctgggc gtcattacga gaaaaacacg agggggcaca tatttcaacg ataaaatcgg 255061 catgcagcca ttttccgtca tgcttgcttt ggccactgat aatcttccgg ctatcattga 255121 agcgcggatg gcgctagaac tcgggctcgt gacaattgcc gcggaaaaaa tcaatgagga 255181 agagcttcag cgtttgcaga agacgatcga cgatattgcc aacagcactg acaatcatta 255241 tggtgaagcg gataaagagt tccatcgaat tattgcgtta agcgccaata accccgtcgt 255301 tgaagggatg attcagtccc tgctgatcac ccatgcgaaa attgacagcc aaattccgta 255361 cagggagaga gatgtaacgg tcgaatatca caaaaaaatc tacgacgccc ttgccaaaag 255421 agatccgtac aaagcacatt accacatgta tgagcatctg aaatttgtcc gtgacaaaat 255481 tctaaaagga atggatgaaa aataatggtg agcaaccgca gttgaaacgt aagagctgcg 255541 gtttttttaa accaatttag aaaacgctta ctaaaatatg aggagtgatt ttcatatggc 255601 gatgaacctc aggaagaacc aagcccccct ttacatcaaa gtgcatgaaa tagataacac 255661 cgcgattatt gtaaatgatg gagggctgcc aaagggcact gttttctcat gcgggctcgt 255721 acttgaagag gatgttcctc aaggccataa ggtggccctc accgatctca atcaagggga 255781 cgagatcgtg cgttacggag aggtgatcgg atttgctgat gagacgatca aacgcgggag 255841 ctggatacgg gaagccctcg tgagaatgcc cgctcctccg gcgttagacg atcttcctct 255901 cgcaaacagg gtgccgcagc cgcggccccc acttgaagga tatacatttg aaggataccg 255961 aaatgcggat ggcagtgcgg ggacaaaaaa tatcctcggc atcacgacaa gtgttcaatg 256021 tgttgttggc gttttggatt atgcagtcaa acgaataaaa gaagagctgc tgccgaaata 256081 cccaaatgtc gatgacgttg tgccgctgca tcatcaatac ggatgcggcg tggcgatcaa 256141 tgcgcccgac gctgtcattc cgatccgcac gattcaaaat cttgcgaagc atccgaactt 256201 cggcggtgaa gtaatggtaa tcggattggg atgtgaaaag ctcctcccgg aaagaattgc 256261 ctccgaaaat gatgatgaca ttctatcgct ccaggatcac cgaggttttg cggcgatgat 256321 ccaatccatt ttggaaatgg cggaggaacg gttaatcagg ctgaacagca gaacccgggt 256381 gtcatgccct gtttcggatc tggttatcgg cctgcaatgc ggcggcagtg atgcgttttc 256441 cggcgtgacg gcgaaccctg ccgtggggta tgcggctgat ttattggttc gcgcaggtgc 256501 aacggttttg ttttctgaag tgacagaggt gcgggatgcc attcatttat taacgccgcg 256561 ggctgtcagt gaagaggtcg gacaatcgct gatcaaagag atgaagtggt atgacagcta 256621 tcttcggcgg ggagacgcag accgtagcgc aaacccgtca ccaggcaata aaaaaggcgg 256681 attatccaat gtggtggaaa aagcgttagg ttcggtagcg aaatcaggca caagccccat 256741 ctccggcgtg ctcggccctg gtgaaagagc aaagcaaaaa ggcctgctgt tcgcggcgac 256801 accggcaagc gattttgtgt gcggcaccct gcagctggct gcgggcatga atttgcaggt 256861 gtttacgaca gggagaggaa caccatatgg cctggctgct gcgccggttc tgaaagtatc 256921 gacgcggcat tccttatcag agcattgggc tgatttaatc gatatcaatg ccggccgaat 256981 cgcgacagga gaggccagta tcgaagacgt aggctgggaa atcttcagga cgattttgga 257041 tgtggcaagc ggccgcaaac aaacgtgggc agaccgttgg ggtcttcata atgatttgtg 257101 cttgtttaat cctgctccag tgacttgatt catgttttta tagcggaaag atggaatatg 257161 ctgtaaaatg aaaatcagcg tataggaaac ggaggggtta cagcatggca ttcattagat 257221 tccgagtgac acgaattcaa tagtgaacaa ctctcgcctg aatgcgagag aatcgggatg 257281 aatccgccta tgtatgagcc cttatatggt tatcaaaaaa gagggtggcg tgcctgccct 257341 tttttgtgcc ttcaagcatc ccttctctct actgcaggcc ggagcatgag aaaggggaaa 257401 tgggatgaca aaccttaacg aaaaacagct tatcactgag attgtcgggc ttgcacgcag 257461 ccaaggtttg acggttcatt ctgagaacgc gcaattgaat gaaaccggaa tggactttca 257521 agttgtattt gccaaggacg acacaggtat gccatgggtg ctgcgaaaac cgcggcgaag 257581 tgatgttgtg gaaagagcat ctgcagaagg cataacgctt gcctttctcc gcgcgaatct 257641 gactgctgat gtgccggatt ggagaattca tacaccggaa ttgatcgctt accccatgtt 257701 aaaaggaacg ccggctgctg gaattgactt ggaacaaaag caatatgtat ggaatatgga 257761 tcatcagccg ccgtcagacg actttgtccg cacacttgcc gacatactgg ctgaattaca 257821 tggcacggat caaatatctg ctgggcaatc cggaatagaa gtgataaggc cagaagattt 257881 caggcaaatg acagcagact ctatggttga tgtgaagaat aagcttggcg tatctacgac 257941 gctttgggaa agatggcaaa agtgggtaga tgatgatgca tactggccgg gtttctcttc 258001 tttgatacac ggcgatctcc acccgccgca tatccttatc gatcaaaatg gacgtgtcac 258061 aggacttctg gattggacag aagcgaaggt tgctgaccca gccaaggatt ttgttcttta 258121 tcaaaccatt ttcggagaaa aagaaactgc ccgtttgctt gaatactatg atcaagcagg 258181 cggccgaata tgggcaaaaa tgcaggaaca catctcagag atgcaggcgg cgtatccggt 258241 ggaaatcgcc aagctagctc tgcaaacaca gcaggaggaa cacatcaata tggcgctgga 258301 agcacttggt gtaacatcgg attaagaatt gacttcgttt catgaaccga gtattataaa 258361 ctctacaaat aatagaacgg attaacaatc gtgaggaaga gcaagtacgc atcagaatgg 258421 aggttcagag agtcggtggc aggtgtgaac cgatcctccc ctgatgccga atgggcttct 258481 gaattgcttt gctgaacgga tagtaggcga tgccgggttt ctctccccgt taccaagaga 258541 ggagtatcga aacataggtt ttctgtactt agagtgaacg gctgtatagc tgttaataaa 258601 ggtggtaccg cgagaccctc gtcctttgca taggacgggg gttttttgtg tttcttaaag 258661 gaggtgacgg ccaatgtacg atggctggtg gtggcatagc agatgagtta gaaaggagga 258721 tatcaaatgg tcattgcaac tgatgatctt gaggtcgcat gtcctaaatg tgaaagagcg 258781 ggagaaatcg aaggaacacc ttgcccggcc tgcagcggaa aaggtgttat tctgactgct 258841 caaggatata cgcttctcga ttttatccaa aagcatttga ataagtaaag gagaaaagct 258901 gagctgagat gagagcagaa gagcagagta agattcgtga ggccgcagca ggtacgattt 258961 ttttgctgat cggaacagtt tgttttgcgt ctaaatcgat ttggataaaa tgggcatacc 259021 aaatgggtgc tgagccagat gccgtgctgc tatacaggca gctgctggct gttccgctgt 259081 tttggctgat ttttttaata taccgtcctc caatgccaga cggtaagaaa aaaggagacc 259141 tatggaaggc ttgtggcgcg ggagtgtttt gtttttttct gtctcccttg cttgatttta 259201 tcgggctgaa ccatgtatcc gcaatggttg aacgtatatt gctgatgagc tatccgttgt 259261 ttgtgtttgg attcaccgcg tgtcgtgacc ggaaaatgtc ctcaattcag gaccttttcg 259321 cagttctggc ggtcatgttt gggcttttct tggcgctggg cggctggaat gctgagcttt 259381 tccaggcgaa tatgattgga gctgtattca ttttgttatc ttcggccgtc tatgctggtt 259441 atcttgtcct ttccgggcat ctcgtccatc aaatcggagg gatccgtctc aatgcatacg 259501 ggatgacagc tgctggagct gccatgatgc tttacacagg gataaaatcg gcggctggca 259561 tgaatacgcc aatggcagca tatccgcttt ctatgtatgg tttgttcgca gtaattgcag 259621 tcgttaccac agtgattcca tttgtgctaa tgcttgaggg cataaaacga atcggggcac 259681 agcgagccgc cgccatttca atggcagggc ctatcctgac gattttctat ggagctttat 259741 ttctcggtga acggctcggg ctcattcaag tcattggatg cggtggcgta ttttttgtca 259801 ttacgggcat ggaatacagg aagctgaaaa caggaaaaaa agaataattt ttataaaaca 259861 cacacgtttt tcaattacaa taagtgtaat tacgtgtgtg ttttttgatt ttgtaaaggt 259921 taggtgagga gatgcagcgc atattgcttg tagaagacga ccactcaatc agtgaaatgg 259981 tggatcatta tttaacaaaa gaaggctttg gaattgtgca tgctttcgac ggagaagagg 260041 gcatccggct gtttcagcag ggttcatacg atttggtcct ccttgatatc atgctcccga 260101 agctgaacgg catggatttt ctgaaaatca tccgggaaaa aagcaatata ccggtcttaa 260161 tgatttcggc aaaagatgga gatgtggaca aggcattggg actgggcttt ggggcggatg 260221 attatatcgc caaaccgttt tcgatgattg agctgacagc ccgagtaaaa gccgcgatac 260281 ggcgggcgac gcaatattcg gcagaggagc cggctgtgaa taaggtgatc cggattcacc 260341 agcttgcgat agatatagac aatgtttccg ttttgaaaaa cggagagccg ctccagctga 260401 cgtcaacaga atggcagctg ctgtgcttat ttgcatcaaa tcctaaaaaa gtgtttacga 260461 aagaacaaat ctaccgttcc gtttggaatg aagagtactt tgatgatcag aacatcatta 260521 acgtacatat gcggcggctc agagaaaaga ttgaggatga cccctcctcc cctcaatata 260581 ttaaaacgtt atggggcatc ggttataaat taggagagtt ttagaatgac agtgctatgg 260641 gtggccgctg tcatcgctct ggcgtgtctg aatgtgattc aattcataat gaaaaagaag 260701 cgggacggga atctggctta cacggctgac cagcttagct acatgctcag ccgggattcg 260761 gcaggacaaa ttttgcttcc tacagacgat catgcgctca aagacttgct tgttaacatc 260821 aatcttatcg ttgagaatcg tcagcagatc agcgcccaat ttgccaaaac agagcaatcc 260881 atgaagcgga tgctgaccaa tatgtcgcac gacctgaaaa cgccgttaac ggtcattctc 260941 ggttatattg aagccattca aagtgacccg aacatgccgg acgaagagcg ggaaagattg 261001 ctggggaagc tccgccagaa aacaaatgaa cttattcaga tgatcaattc cttttttgat 261061 ttagcgaaat tagaatctga agataaagag atcccgatca ccaaagtaca tatgaacgac 261121 atatgcaaac gaaatatcct gcactattat gacgctgttc agtcaaaagg ctttcaagca 261181 gccatcgata tccccgatac gccggtgtat gcgcaggcga atgaagaggc tctggacaga 261241 atcctgcaaa acctattgtc caatgcgatt caatatggcg cggccggcaa gttaatcggg 261301 ctgacgctgt cttatgatga gaggaacatc gccatcaccg tatgggatcg cggaaaaggg 261361 attagtgaaa ccgatcagca gcgggtgttt gagaggctgt acacactgga agaatccaga 261421 aataaagcat ttcaaggaag cggcttgggt ttaaccatca caaaacggct tacagaaaaa 261481 atgggaggca tcatatccgt ccaaagcaag ccgtacgaac ggactgcatt tacgatcaca 261541 ttgaaacgca tgacatatta atcgtaagaa tttcttaagg tttgagaaat aaaaatgaca 261601 gggctcgccg ctacaataga aaacaggaaa agagagggaa ggagaaacaa agttgactta 261661 tatcgtacaa acaaacgggc tgaccaaaac atatcagggc aaagaggtcg tatccaatgt 261721 cagcatgcat attaaaaaag gtgaaatcta tggctttctc ggcccgaacg gcgcggggaa 261781 aacaaccatt atgaaaatgc tgacgagcct tgtcaaaccg acaagcggtg aaatcatcat 261841 ccttgggaac aagttcaccc acacgtcata tgaggtgctg gggaacatcg gcagcatgat 261901 tgaatatccg attttttatg aaaacctgac agctgaagaa aatttagatc tgcattgtga 261961 atatatggga taccacaata aaaaagccat acaagaagtg ctggatatgg tgaatttaaa 262021 acaaatcgac aaaaaacccg tcaaaacctt ttccctcggg atgaagcagc gccttggaat 262081 tgcgcgtgcc atcctcacga agccggacct gcttattctg gatgagccgg tgaatggtct 262141 tgaccctctc ggcattaaaa agatcaggca attgtttcaa gtgctgagca aagagtacgg 262201 gatgacgctg ctgatctcaa gccacctgct gggtgaaatc gaacaaatcg cggacacaat 262261 cggcgtcatt cgggacggca ggctgcttga agaggtatca atggaggatg tcaggggcca 262321 gaacactgaa tacatcgagc ttgtcacgcc gaatcagaca agggcctgct ttgtgctgga 262381 gaaagagctg caattaacca actttaaaat attaaatgag aaaacgattc gaatttacga 262441 ggctgaagcc tctcaggctg ccatatccaa agcattgatt ttaaatgatg tagacattga 262501 atcaatgaac aaaaagtata cgtcgctgga ggattatttt atcaaattga tcaacggcaa 262561 tagcatcagt gcgtaaagga ggagagacac gttgatgaat ttgatcagaa tcgaattaag 262621 aaaaatgaaa atgggctggt atatcagagg tgccctcatt gccaacgtga tcattatggg 262681 ttttatgtgg ctgatcagtt attccgaaaa agccgatggc ggggtttcgt tccaaagtac 262741 ggatgaagca ttcctcatca tcggcacctt cgtcagagcg gtatttatcg tatttggcgc 262801 tgtgctgatc gtaaaattgg tgatttcgga atataaaaac aaaaccattc ttgtgatgtt 262861 cacgtacccg atcagccgta aaaagctgct caccgctaag ctcatgatcg cgggcggact 262921 gacgtttatc acgattttac tttcaaatat actcatagcc gccggtttct tttggctgaa 262981 ctcgatctgc catttcatac cgggagagct tacttccgag atcatttctc aacaggcggt 263041 caaaatggcg gttttcgctt ttggcgccgc tggaaccagt ttagttccca tcttttttgg 263101 gatgcgtaga cactcggttc cggcgaccat catttcatct gtagtaattg tgatgctcat 263161 cagctcaaca agtccgggct tctcgatttc atctgttgtg tatatcccgt tatcgttagc 263221 ggcattcggt ttgttctttt cctacatggc gatcaggaat gcggacaagc aggatgcgta 263281 aacaaaggcg cccaatatgt ataaaaggcc gatgctgtca gcaccggcct ttccattatg 263341 agtctgttct tgtttcaaga taatgcttct tgccaatctc tttgctcatc atatagaaat 263401 ggaagcaata ttcaccgatt gccatgacga tcgcgccgaa taaagccgcc aatgcaactt 263461 caccgccagt catccccata gaaagcggca tgcccatcag ccagatcacg agaaaggcca 263521 aaccaaaatc agccaaagtt gcaatcatat tattccattt cggcaataca taaagatcgc 263581 ccagcaaata agaaataacc cctaacacaa tcgtcattag cagcgtatca ccaaacgtga 263641 aaccaaagcc cagaccaagc accagataca acacaataat cgtcataata cctttaatag 263701 cgagcgcttt cacatgtgtc attacaattc ctccttttgt catttgattt gttatgtata 263761 attcctcaaa tgtaaaaagt taaaccttat ttcttttcgg aggcgggtgc aaatctgctg 263821 gggagaggtc aatgatgtga atccaggaat tgaggctgcg gcgcttcgac agcggaaacg 263881 tgaagcttgt actgcaccgg acgctgcttt gatgcccaac agcccattat gtttgctgtt 263941 tttagatgaa taaatttaaa aacttctcct gtccctccgt catcacttct gaagtaatga 264001 aatatgatga aaagagatca aggggaggtg acgtgatggc ggtcgtgaga gcaacgagtg 264061 cggatgtcga tttgatggca aggctgctca gagcggaagc ggaaggcgaa ggcaagcagg 264121 ggatgctgct tgtcggcaac gttggaatta atcggctgcg ggcgaattgc tcagatttta 264181 aaggcctccg caccatcagg cagatgattt atcagccaca cgcgtttgag gctgtgactc 264241 atggatattt ttatcaaagg gcgcgagata gcgagcgtgc ccttgcacgc cggtcgatta 264301 atggtgaaag gcgctggcct gcaaaattta gtttatggta cttcaggccg cagggggact 264361 gtccagccca gtggtataac cagccgtttg tggccagatt taagtcacac tgcttttatc 264421 agccgacggc ggagacgtgt gaaaatgtat ataacacatt ttagagacag gacaccgttc 264481 aaattgaacg gtgtttttct ttgaaaagat gcaatgcaaa atattcctgt gagataatca 264541 aagaaaaaag agctgacgga gatgacagaa tggcaacaat tgacctgcaa aagaaaagtg 264601 taaagatcgt actggagaaa aagcagttaa cgaaggtgac ggctcgtgtt ggactggttc 264661 ttgatattac gggatcgatg agaccgctct acaaaaacgg gacggttcaa aatgtggtgg 264721 agcggatttt ggcagtggct gatcagtttg atgataacgg tttgctggat gtatgggtgt 264781 atgataatga attttcccga ttaaagccag tttcagaaaa ggatttttcg ggctatgtcg 264841 atcgtgaaat tttaaataat gaccgcttgc ataaattcgg cagaaatgat gagccgccag 264901 tcatgaagga cgtgctgcgc aaatatgtta cggaggaacc gagctcgtat cctgctttca 264961 ttgtttttat caatgacggg ggctgtaaaa agtcaatcaa accgataatt gaagcttctt 265021 ctgataaacc ggtgttctgg cagtttgtcg gcatcggaaa cggaaacttt gattttctca 265081 ataaactgga tacgttagaa gggcgtgtca ttgataacac gaacttcctg catatcgaag 265141 agattgaccg catttctgat gatgagcttt atgatgctct gcttgctgaa tttccatttt 265201 ggctgaaaga agcgaaggaa aaagggattg taagagaaca agagcctcct gctgaaaagc 265261 cgaaaaagaa gggctttttc agcagattgt tttcgaaata actgataaag agcactgagt 265321 cattctgcga aatggctcgg tgtttttgtt tttttaagat catgtgaaga aaaataggcc 265381 gaatgggcgg cttgcaaacg acaggatatg cagaaaacgc gtcattcagc cagctttcgg 265441 catgtttcag cagcaggctt gtgagggaag acctgttttt aatgttcagc gcttacaatc 265501 agttcacact tcttcacagt cgtttaacaa tgatttccta taatggagac gatcaatgag 265561 gagagagggg atcttgaatg gcatacgaca gtcgttttga tgaatgggta cagaaactga 265621 aagaggaaag ctttcaaaac aatacgtttg accgccgcaa atttattcaa ggagcgggga 265681 agattgcagg actttctctt ggattaacga ttgcccagtc ggttggggcc tttgaagtaa 265741 atgctgcgcc taacttctca agctatccgt ttacattagg ggtagcgtca ggtgatccgc 265801 tttctgacag tgtcgtgctt tggacacgtc tggcaccaga tccgctgaat ggcgggggaa 265861 tgccgaagca agcagtgcct gtcaaatggg aggtcgcaaa ggatgagcat ttccgcaaaa 265921 tcgtaagaaa aggcactgaa atggctaaac caagtcttgc ccattccgtt catgtggaag 265981 cggacgggct tgagccaaac aaagtgtact attaccgttt caaaaccggc catgaactaa 266041 gccctgtcgg aaaaacaaaa acactgcctg cccctggcgc caatgtgccg caaatgacct 266101 ttgcatttgc ttcctgccag caatatgagc acggatatta tacggcctac aagcatatgg 266161 caaaggaaaa gcttgatctt gtcttccatc tcggtgatta catatatgaa tacggcccaa 266221 atgaatatgt atcaaaaaca ggcaatgtcc gcacgcacaa cagcgcggaa atcattacgc 266281 tgcaagacta tcggaaccgt cacgctcaat accgttctga cgccaatctt aaagctgcac 266341 atgcggcatt cccttgggtt gtaacttggg atgaccatga agttgaaaac aactatgcca 266401 ataaaatacc tgaaaaagga cagtcggttg aagcattcgt gctccgccgc gcggcagcat 266461 accaggcata ctatgaacat atgccgctcc gcatttcctc tttgccgaat ggcccagata 266521 tgcagctgta ccggcacttt acgtacggaa acctggcgtc cttcaatgtg cttgataccc 266581 gccagtacag ggacgaccaa gccaataacg acggcaataa gccgccttct gatgaatcgc 266641 gcaatccgaa tcggactctg cttggaaaag aacaggagca gtggctcttc aacaatttgg 266701 gcagctcgac agcccactgg aatgtgctgg cgcagcagat tttctttgcc aagtggaatt 266761 tcgggacaag cgcaagcccg atctacagca tggattcgtg ggacggctac ccggctcagc 266821 gcgaacgggt tatcaatttc attaaaagca aaaatctgaa taatgttgtc gtactgacag 266881 gtgatgtaca cgcaagctgg gcatcgaatt tgcatgtcga tttcgagaag acaagttcaa 266941 aaatattcgg agccgaattt gttggaacct cgatcacttc cggagggaac ggagcggata 267001 agcgagcgga tacggaccaa attttaaaag aaaatccgca catccagttc tttaacgact 267061 atcgcggata tgtccgctgt acagtgacgc ctcaccagtg gaaagccgat tatcgggtga 267121 tgccatttgt gaccgagccg ggcgcagcca tttccacgcg ggcttcattc gtttaccaga 267181 aagaccaaac cgggttgaga aaggtatcat ccacaacaat ccaaggcggg gtgaagcaat 267241 ccgatgaggt cgaagaggat cgtttctttt cgcacaacaa agcccacgaa aaacaaatga 267301 ttaagaagcg tgcaaaaatc acgaattaag gagtggaaat tatgttttca aacattggaa 267361 taccgggctt gattctcatc ttcgtcatcg ccctcattat ttttggccct tccaagctgc 267421 cggaaatcgg gcgtgccgcc ggacggacac tgctggaatt taaaagcgcc acaaaatcac 267481 ttgtgtctgg tgatgaaaaa gaagagaaat cagctgagct gacagcggta aagcaggaca 267541 aaaacgcggg ctgaatgctg atgaggcaga caccgggtct gcctcttttt ttatgaaagg 267601 gagggctttt ttgaatggat aaaaaagaaa cccatctgat cgggcattta gaagagcttc 267661 gccgccggat tatcgtcacc cttgcggcat tttttctatt tctcatcacg gcttttttgt 267721 tcgtacagga catttatgac tggctgatca gggatttgga tggaaagctg gctgtgctag 267781 gaccgagtga aatcctctgg gtgtatatga tgctttccgg catttgtgcc attgcggctt 267841 ctatccctgt tgccgcgtac cagctgtggc gtttcgttgc accggcgctg actaaaacgg 267901 agcgcaaggt gacgctcatg tacataccag gtttatttgc gttgtttttg gcgggcatct 267961 ccttcggata ctttgtcttg tttccgatcg tgctcagctt tttgactcat ttatcctccg 268021 gccactttga aacgatgttt acggctgacc gctactttag gtttatggtg aatttgagcc 268081 tgccgttcgg cttcttgttt gagatgccct tggtggtgat gtttttaaca aggctgggca 268141 tcttaaatcc ttacagactg gccaaagcga gaaagctttc ctattttctg ctgattgtcg 268201 tgtccatatt gattacaccg cctgatttta tttctgattt tctcgtgatg atcccgcttc 268261 ttgtcctgtt tgaagtgagt gtcaccctat cggcgtttgt ctacaaaaag aggatgaggg 268321 aagaaacagc ggcggccgct tagtgcagcg taccacccgg tgacttcaca tcctcatcat 268381 attgtgcggc cgtaacagcg gcgattctca atgcccggac aatcgtgtcc aggctgaggc 268441 tcggcgctgt tttgtcgatt gtttgctgcg gaatgtaagg aatatgaata aaaccgccgc 268501 gaatgtgtgg ggatgtccgg ctaatgtgat ccattaaccc gtagaacaaa tagttgcata 268561 caaaggtccc cgctgtgtag gaaaccgcag ctggaatgcc gtgttccttc atcttagcag 268621 tcattcgttt cacgggaagc cttgtccagt aagcggcggg cccatctgga gaaatctctt 268681 catcaatcgg ctgatgtcct tcgttatcgg ggattcgcgc atctgcaagg ttgattgcca 268741 ctcgttccgg tgtaatctgc atccgtcctc ctgcttggcc gacacaaatt acgatatctg 268801 gctgatgttt ttgaatggct tggcgcagag tgtccagagc ggatctaaag acggttggaa 268861 tttgttccgc tgtaataatg gcttcttctg tctcgaagcc attaagccgt ttcgccgctt 268921 cccatgatgg attgacggtt tctttgtcaa aagggtcaaa gcctgtgatc agcacttttt 268981 ttctcattct cccatctcct ttttctttta ttctattgtt tatttatggg tttttcatca 269041 aaataatgta aaggagtgaa tcataatgga gcatttgccg gagcagtatc gccagttatt 269101 cccaaccttg cagacgcata cgatgcttgc cagctgttct cagagcgcat tggcagagcc 269161 tgtatcaagg gcgatccagg attattatga tagcctgctg tataaaggga cgaactggaa 269221 agaagcgatt gaaaaaacag agtttgcgag aaacgagttt gcaaagctga tcggggctga 269281 accggatgaa gtggcgattg tgccgtcagt ttctgatgca ctggtttctg tagcatcgtc 269341 cttaactgca tttggaaaga agcacgttgt atatacagat atggattttc cggcggtgcc 269401 tcatgtttgg caggcacact ccgattatac cgtatccgtc attccatcaa tagacggcgt 269461 gctgccgctt gaacaatatg aaacgcatat ttcggatgaa acagtactga cgtgtgttcc 269521 tcacgttcat tatcgtgacg gctatgttca ggatataaaa gcgattgccg agatttctca 269581 gagaaagggc tctttattgt ttgtagatgc ttatcaatca gccgggcata ttcccattga 269641 tgtgaaggaa tggggcgtag atatgctggc agcaggcacc cggaagtatt tgctcggcat 269701 accgggtgtg gcgtttcttt atgtgagaaa ggagctggct gacgcactga agccgaaagc 269761 atcagcttgg ttcggaagag agagcggatt tgatggggct tatgcaaaag tcgcgcgccg 269821 ttttcaaacg ggcaccccag cttttatcag cgtatacgca gctgcagcgg ctttatcgct 269881 gctgaatcat attggggttt ctcatatcag ggatcatgtg aaaacgatct gtgccgatgc 269941 agttcaatat gccgctgaaa aaggcctgca gctggcggcg gcacaaggtg ggattcagcc 270001 gggcatggtt gcgatccggg atgagcgggc atcggaaacg gcggggttgc tgaagaagaa 270061 aaaagtgatt tgcgcgccgc gggaaaatgt tatccgtctc gctccccatt tttataatac 270121 gaaggaggaa atgcggcacg cgattgatga aatcgcggcg aaaacgatcc acaagtaaac 270181 atgaaaaagc ccctgaacac tagtcagggg cttttcatat taatgatcta ctttaacgcg 270241 tttcataaag aaagcgccaa ttaaaccgat aatggcaaca atcattgcaa acacaaatgc 270301 gtgctgtacg cctgctgtca aagcttgcgg gatgactgcc ggatcggcag ggtttttaac 270361 tgtactcata taatcatgct ggcctgcagc cataatgctg accgcaaccg ctgttccgat 270421 agcgccggcc atttgctgca gcgtgttcat aatggcggtg ccgtctggat aaaattcacg 270481 cggcagttgg tttaaaccgt ttgtctgtgc aggcatcatg atcatagaaa tcccgatcat 270541 caagcaggtg tgcaggatga taatcagcac agctgttgaa gtggtcgtga catttgagaa 270601 gaaccatagt acaacggtga caatcacaaa tcccggaatg acaagccatt tcggcccgta 270661 tttatcgaac aagcggcctg taacagggga cataaatcca tttaaaatac cgcccggcaa 270721 gagaacaaga ccagatgcaa atgcagtgag gactaagccg ccttgcagat acatcggcag 270781 aagcagcata gatgacagaa tgaccatcat acaaatgaac accatgatca cacccaaaat 270841 aaacatcggg tatttgaacg cacggaggtt catcataggc tgcttcattg tcagctggcg 270901 gattgaaaat aagataaggc cgacaacgcc gacaatcagc gacacgataa cagtcgggct 270961 ggaccatccc ccggagcctt cacccgcgtt gctgaatccg aatacaatgc cgccgaagcc 271021 aatcgtcgac aggatgatag acaatacatc gattttcggc tttgtcgttt cagatacatt 271081 ttgcatatat gcgataccga aaacaagcgc cagcacaagg aatggaagag agatccagaa 271141 aatccagtgc cagttgagat gctccagaac caatcctgag aaagttgggc cgatggcggg 271201 cgcgaacata atgacaagcc cgatcgttcc cattgcggca ccccgtttat gaggcgggaa 271261 aatcaccaag attgtgttaa acatcagcgg cagtaaaaga ccggttccaa gtgcctgaac 271321 gatccttgcc gctaataaaa acgagaagct cggcgcaagc gccgcaatga atgtacctaa 271381 aattgaaaag ataagtgaca cggtaaaaag ctgtcttgtt gtgaaccact gcaacagcag 271441 tcctgaaaca ggaacaagga taccgagtac aagcaggtag cccgtcgtta accattggac 271501 ggttgccgct gtaatgttca attccttcat aaggtcggtt aacgcaatat tcagcgctgt 271561 ttcactgaac atgccgataa aaccggccaa cagcaaggaa atcataatcg gcatcacttt 271621 gtattgctga gatgctttag ctgttgtttc caaaatcatt tcccctctct atcaactgca 271681 tgtagtatgt cgtttttttt atctcttcag caggtcagga atgcagctgg agatatgaag 271741 gagcggcgta ctgttttttg ccgtcaaaga taaaaggatg ccgccttcaa tcatcgcgtt 271801 aaccacagtg ctggcttctt ttgcacggct ctcgctgcag ccagtctgcc gcagtttttc 271861 ctcatacaca gaggcccatt ctttgtaggc ttcatgacag gcttcgcgca acggttcgct 271921 tttcaatgac gtctcagccg ctagcaagcc cacaggcaag ccttcaatgt cttccgtaca 271981 tgaaaactgg caggagagct ccttcaaaaa ggcttgaatg ccttccgctg gatcggtgca 272041 ggcttccatg cagtccgcga ttttctgacg gatatactcc ttcatctcat tcacggcttc 272101 gatcgcaagc tgttctttac ccccgggaaa gtggtagtaa agagagcctt taggcgcgcc 272161 gctttccttt ataatctggt tcagccccgt gccgtaatac ccttgcagct gaaaaagccg 272221 ggtagctgcc gaaaggattt tctcacggga atctccataa ctcataacat tcccacctta 272281 ctgaattgca atcaaaaata tagtgactgg tctattatct tgattcaatc atcaattgtc 272341 aagaaaaatt cattgtatga aaagacaaaa aaagaaggat atgacaacaa aaaatactga 272401 gagaaaagct gactgatctt ttgactgaat agataaaatg tacaatgatt aatcatcata 272461 tggatgtaag gagagaaata gatgaaaaaa caacgaatgc tcgtactttt taccgcacta 272521 ttgtttgttt ttaccggatg ttcacattct cctgaaacaa aagaatcccc gaaagaaaaa 272581 gctcagacac aaaaagtctc ttcggcttct gcctctgaaa aaaaggatct gccaaacatt 272641 agaattttag cgacaggagg cacgatagct ggtgccgatc aatcgaaaac ctcaacaact 272701 gaatataaag caggtgttgt cggcgttgaa tcactgatcg aggcagttcc agaaatgaag 272761 gacattgcaa acgtcagcgg cgagcagatt gttaacgtcg gcagcacaaa tattgataat 272821 aaaatattgc tgaagctggc gaaacgcatc aaccacttgc tcgcttcaga tgatgtagac 272881 ggaatcgtcg tgactcatgg aacagataca ttggaggaaa ccgcttattt tttgaatctt 272941 accgtgaaaa gtgataaacc ggttgttatt gtcggttcga tgagaccttc cacagccatc 273001 agcgctgatg ggccttctaa cctgtacaat gcagtgaaag tggcaggtgc ccctgaggca 273061 aaagggaaag ggacgcttgt tgttcttaac gaccggattg cctcagcccg atatgtcacc 273121 aaaacaaaca caactacaac agatacattt aaatcagaag aaatgggctt cgtcggaaca 273181 attgcagatg atatctattt taataatgag attacccgta agcatacgaa ggacacggat 273241 ttctcggttt ctaatcttga tgagctgccg caggttgaca ttatctatgg ataccaaaat 273301 gacggaagct acctgtttga cgctgctgta aaagccggag caaaggggat tgtatttgcc 273361 ggttctggga acgggtcttt atctgatgca gccgaaaaag gggcggacag cgcagtcaaa 273421 aaaggcgtta cagtggtgcg ctctacccgc acgggaaatg gtgtcgtcac accaaaccaa 273481 gactatgcgg aaaaggactt gctggcatcg aactctttaa acccccaaaa agcacggatg 273541 ttgctgatgc ttgcgcttac caaaacaaat gatcctcaaa aaatccaagc ttatttcaat 273601 gagtattgaa gaaaagaagg cgaataagcc ttcttttttt tggcttttta ggaccaataa 273661 tgacctctga atcttaaaat ttctttaaaa ataagccaaa attacccttt acttaattaa 273721 tttggtaacg taatataatt ggagaatttg ttacaaaaaa aggaggatat tatgaaattt 273781 gtaaaaagaa ggatcattgc acttgtaaca attttgatgc tgtctgttac atcgctgttt 273841 gcgttgcagc cgtcagcaaa agccgctgaa cacaatccag tcgttatggt tcacggtatt 273901 ggaggggcat cattcaattt tgcgggaatt aagagctatc tcgtatctca gggctggtcg 273961 cgggacaagc tgtatgcagt tgatttttgg gacaagacag gcacaaatta taacaatgga 274021 ccggtattat cacgatttgt gcaaaaggtt ttagatgaaa cgggtgcgaa aaaagtggat 274081 attgtcgctc acagcatggg gggcgcgaac acactttact acataaaaaa tctggacggc 274141 ggaaataaag ttgcaaacgt cgtgacgctt ggcggcgcga accgtttgac gacaggcaag 274201 gcgcttccgg gaacagatcc aaatcaaaag attttataca catccattta cagcagtgcc 274261 gatatgattg tcatgaatta cttatcaaga ttagatggtg ctagaaacgt tcaaatccat 274321 ggcgttggac acatcggcct tctgtacagc agccaagtca acagcctgat taaagaaggg 274381 ctgaacggcg ggggccagaa tacgaattaa tgaaaaacaa aaccttgaag aatgctattc 274441 ttcaaggtta ttctgctttc agcacaatgg ttttcgcagc catatcatga acggtttgtt 274501 ttttcttcgt aaatgcggca gtcaaataga tcaggcggga gaacacatgc acccacgcta 274561 tcaggtaacg gacaatggct tgcgggaagg atattttttt atatgtttcg tccctcacga 274621 tttgcagccc gatgattttt ttgcctagtg tgcccttcca atttgtcagc ggcatcagca 274681 aagggtacac aatcagcatc aatatggcga caataatgac accggcggac ccatcgccaa 274741 acgtaaatcc ggctgccaaa atcactgctg cggcaatgat tacatcaagt aaaagagcgc 274801 aggcgcgcag catgaaacca gctagttcca atagaaacac tccttaaaat gttaaataaa 274861 cacctaatga ttgtaaaaaa gaagggccta aagtgggaat aggtgataag ccttaaatca 274921 caaaagttgg tgaaaatgtc ataggtaaat tggcataatc agccagctta tcacattacc 274981 aaattctttt ttagcccgaa accaagccct cagaagttat ttttgttaaa atagaaaagt 275041 tacaacagaa ttcggagggt ttattgtggg aaaagtgaaa cgaaatgccc cttgcccatg 275101 cggcagcggc aagaaatata aaaaatgctg cggaagtaaa gttgtcgact tcccggcgga 275161 actagcggca aaagaagcga aacaaattca ggaagactta gtggagtatg ccttcacagt 275221 acatagagaa agcatttcag gctttatcaa ccagcatgat tttctttctg ctatggacag 275281 acagacgaaa gacatcagcg tatttaactt aggaatctgg ggaatcttct tccacccgct 275341 tgctggtgag aagacaatct tcgaagagta ccttcagaaa aaaggcgatt cgatcactcg 275401 tccgaaaacg cgtgagatcg tagaatcatg gcagagcatg acgcctgctt tattgctgct 275461 gaaggacctg aaggaaggca tcattcactt tgaagatgtc attacggcaa aacaattcga 275521 agtggaaatg gacgccagca atcaagacct tcctccagtg ggaagcctga ttcttggata 275581 cccaatccac gaagcggaaa aagcagaatt cttcatgcag ttcacgatct tcccggtgaa 275641 gagaacagaa gcgctgatca gcaaggtgaa gaaatatgcg gatgccgctg tgaaggacgg 275701 caaaacgccg gaggacttca tgaagcagga attcaacaac gttctgttcg cgttgttagc 275761 tgagaaagat gaagagccac aagcagagaa agcggaagta agcactgttg agtgggcaaa 275821 cgacttggag aaagaaaccg ctgcggctat tgaagaaggc atgagcgggg aagagtatcc 275881 gactgaattg atcccagctg ttattgacat ctggaaaaca ttctgcgaga aaaaatcacc 275941 tgtcatcaga aagccggaag cttttgcggc ggcagttgaa tattatgtaa acgcaatttc 276001 tcttaacggc gcgtccgttt cccaggctaa actggcgaaa aaatacggcg ttagcgcatc 276061 aacgatttcc agccgttaca aagaaattga aagcacgctg caagatgaag cagatcgttt 276121 tgcacaagcg ttatcctcat aatggaaaaa accttgaaaa gccaggcttt tcaaggtttt 276181 tttatttctg aaacggaatt ttgatttcta accggaagat ggggtggcgg taggtaaaat 276241 ccagcctgcc aaaagcgccc ttcaccagtt tttgaatgat atatgtgccc atgccttcat 276301 gagcgccgtt tttcgttgag cggccaaacg attgataaat tgtatcgagc acttttgggt 276361 ccatcccggg agtgctgttt tcacaagtca gtacataaag cccgctgcgc agtgaagtct 276421 ccagtttaat ctctgctttt tctcgggcct ccgccgcgct gtcgagcgca ttttctaata 276481 tgttgccgac caagctgacc tgatcagcag gcgaaaacgg aagggaagaa agcggtgtat 276541 gcatatgcag cgaaacactc acattcgagg cgcgggcttt ttctaaaaaa tcataaagca 276601 cccctgcaac gtacgcgttc tctcctttca aaaaacggtc atattggctg tattgatccg 276661 cccagttttg aatatatgct tgtgtatctg ccttgggctg agctgatttg attgcagtga 276721 tatgtttcat tgtgtcatga ttccggcttc tgacatcaat cagcatttga ttggcgtgct 276781 gttcagcttg agtcagctta tcaatttgat cagaaagcct tgcctgcaaa gcagactgtc 276841 cgatacggag cccttcacac cctgcaaata tcgcgattac acataatacc ggcatgatgt 276901 ctgtgccaat caacaccact cccaccgaca tcacttgaat caccgcaatc cacgcacaaa 276961 gccctgagga acagtgtttc cacacccgct tcgtattcca aatgtacaat cctgcagcag 277021 ctgcgcctaa agcagcggcg agccaagagg cggctgtgct gtgtgaaaaa gcagcagctc 277081 cctgataaca tatgaaacta aataaaatca gataaagaca ttgaaaaagg gtaatcacgt 277141 actaaactcc tcaaaaatag tagttttgaa aataatcaag ctgctgctta gtgatcatcg 277201 cttttttaga cgttccctca aaggaaactg tgaatgaatg cttggtataa gcggaaaaat 277261 gctttatgta atgaatgttg ataataaagg aacgatgcga acgaagaaaa tctttttcgg 277321 gcaggtcgcc tttaatatca tttaatgttt gatacgtttg cacctcttcg gcggttgtca 277381 caatcgtcgt cgaacgtccc gtccgttctg cgaaaataat atccttcttt tgcaggacgt 277441 gcatttcaga cttttgcttt atcaatatac gcccattcaa actcgtttcc gttttctttt 277501 tcaagtaccg gtcgaaggaa gcggccagac ggtcggcata gtacggcttc ataatataat 277561 catggacgtt caggtcaaag gcgtgaaccg cataaccgcc gtggccggta acaaaaatca 277621 catccacatc aagtgaatgg gatttgatca aatcagcaag ctcgtagcca gacatatggg 277681 gcatctcgat atcggcaagc agcagatcaa tgtctccgtt ctttacccgc ctgtaggctt 277741 ccttcgctga atcggtggaa aagacaattt cgacgtcctg cattctggac acgatcgctt 277801 ctaacttctc taaatctact cgataatcat ctacaagtcc gacttttacc attatcattc 277861 ccctagttac atagaatcat ctttattcta tcccatttca cgacataaaa agaactcttc 277921 gcgacaactt tatccaacta atccagcttt tcgtatatag tcattactag aaataaagat 277981 aagggagatt gtgacatgat tacactgacc gattgcagcc gcaggtttca ggataagaaa 278041 aaagtagtca aagcggtgcg agatgtaagc ttaacaattg aaaaaggaga agtcgtcggc 278101 attctcggag aaaacggtgc cggcaaaacg acgatgctga gaatgattgc ttccttgctt 278161 gaaccatcac agggtgtaat cacagtagac ggctttgaca cggtcaagca gccggctgag 278221 gtcaaacaaa gaatcggtgt cttattcgga ggagaaaccg ggctttacga caggatgacc 278281 gctaaagaaa atctccaata cttcggcagg ctgtatgggc tgaaccgcca cgagatcaaa 278341 gcaagaatag aagatttatc gaaacggttc ggcatgcgcg attatatgaa ccggagagtg 278401 ggcgggtttt cgaaaggcat gaggcagaaa gtcgccattg ccagagcgct gattcacgat 278461 ccggacatca ttttatttga tgagccgaca actgggcttg atattacgtc aagcaacatc 278521 ttccgcgaat ttatacagca gctgaaaaga gaacaaaaaa cgattctttt ctccagccac 278581 attatggagg aagtgcaggc gctctgtgac agtgtcatca tgattcacag cggagaggtg 278641 atttaccgag gggcgcttga atcactatac gagagcgagc gcagtgagga tttgaattac 278701 atctttatgt ctaagcttgt cagggggatt tcttaaatgc tgagccatat ttataaaaaa 278761 gaaatgatcg acgctttacg cgacagaaaa acgatattac tcacaatctt agtgccgatg 278821 attatgatgc ttggacttgt ctttttttat gaaagcatgc tgtccgacaa aggggagcag 278881 tacacgctgg ctgtcggcca ttcgcttccg cccgcactgg aaagcaagct taatgagatt 278941 gacgaaatca gcgtaaaaac atttgcaaag cctgaagagg cagttgatga aggaaaagca 279001 gatgcctatc tgaacgtccc gaaagagttc gactcatatg tcaacagcat gacacctttt 279061 aaggttgatg tttacggcaa ttcaatcgat caagggtcgt caaatgccat gcagcttgtg 279121 cagtctgcct tagatcagta caaaaatgaa attgtgcagc aacgtttaac aaataagcat 279181 attgatcaat cggtgatcca gccgtttaca attcagcaaa aggaagcgga tgaggagaaa 279241 gggacttccg ctattatgct ttccgccatt ctgcccatgc tgattctgac ttccattgtt 279301 tccggcgcaa tgccgatcgc tcttgatatc atggccggtg aaaaggaccg aaagtcaatc 279361 gaggcgctgc tattaacgcc agtcagcaga aacaaagtgc tggtcggcaa gtggcttgcg 279421 gtttccactt ttggcgtggc ttcaggtgta tttgctttgg tgtttttgat tttgtccacc 279481 gtgttattta ccgaaaattt aaaaacggcc ttccagctgg gagatcatat gtggagtgta 279541 atcggcgctt cagccttaat cattgtgctc tctgcattgc tgatatctgc gatggagctt 279601 ttcatcagca tcatgtccag ctcggtaaaa gaagcgcaaa gttatatgtc tctcgtcgtc 279661 tttctgcctg tgttcccgat gtttttcatc ttcagcaagg caccgaacca atttgactta 279721 tcatactttc tcatcccgtt tctgaacctg catgcgttat ttaaacagct tttattcggg 279781 atggttgacc cggctaccat tttgtctacg tcaggaacca tcgccgtgct catcgccatc 279841 ttctttttac tagccagagc ctgcttcctg aaagacaaat gggttcttcc aaaataaact 279901 tgcgaaagga gaaatacact ttctcctttt tgtatatcct gaaaaaagaa ggaaaataga 279961 aaaaggatat ctaatacaaa aagtgaccct gcactatttt tcatcaaaat tggtttcaaa 280021 ggagaaggaa caatggatca aacacgtaca ctcggcaaaa cgaagctgaa ggtgaagcgg 280081 atcggattcg gcgcgaatgc ggtcggcggg cataatctat ttccaaatct aaatgatgaa 280141 acagggaagg atttagtgcg cacggcattg gatggcggcg tcaattttat cgataccgcc 280201 tttatatatg gattggggcg atctgaagaa ttaatcggcg aagtcgtaca ggaacgcggc 280261 gtgcggaatg agctcatcat cgccaccaaa ggagctcata aagaagtgga cggcagcatt 280321 gaattagaca atagccggga gtttcttcgc agcgaggtgg agaagagcct gaagcggctg 280381 aaaacagatt acattgattt gtattatgtt cactttccgg atggaaaaac acctctcgct 280441 gaagtggcgg gcactttgaa agagctgaag gatgagggga aaatcaaagc gatcggcgct 280501 tcgaacctcg attatcagca attgcaggat tttaatgctg acggctattt ggaggtcttc 280561 caggccgaat attctctcat acagcgtgat gccgagaaag agcttcttcc atactgtgaa 280621 aaacaaggca tctcctttat tccttacttt ccgcttgcgt ccggactgct gacaggaaaa 280681 ttcacgcaag acacagtctt tgatgatttc agaaaggata aacctcaatt tcagggtgaa 280741 acgtttatcc acaatctcaa aaaagtagat aagctgaaag cagtagcgga ggaaaaacaa 280801 gcggatacgg cacatgtcgc cttggcgtgg ctgttaacga gaccggcgat tgatgccatt 280861 attccaggag ctaaacgacc ggagcaatta caggataacc tgaaaacctt gaacattgaa 280921 ctgaccgaag atgaagtgaa tttcatcagc gacattttca aataaaaaag gaaatagccg 280981 tcatggctat ttccttttgg tgttttattc tttgatgaat gcttcgacta attctgctgc 281041 tctgtaatca tccatatcaa gctgccattg gtcgatgtca tttttcttca ttttcacttc 281101 aactgttttt tcagatgaag caggtccaag ctttttgaat tcctcaggat agacttgaag 281161 cgcgtatttc actgcctctt catagctggc actagagttt ttactgtagt agtctttcac 281221 tttgtcttcg atgcggtctg aaagagaaga tgcatctaca ggtttaactg tggcttcaac 281281 aattgcttcg tctttagaga ttgaagtcgt ttttgcttga atggaagagt ttttgcttaa 281341 tccctcttta atgccgttca cgatattatc aagcgctttg ctgtccgcat atgtgctgga 281401 aaggccggaa gctgagagat aaccgtcttt ggctgattca ttaaaatcat ttacaatttc 281461 atttttgtta gcgccggtga ttttttcgaa atcggcgtta tctttgccga aaagaaggac 281521 atcaacataa gctgataacg cttttgcaga atcttggagc ttatctgccg tcgccaggat 281581 ttttttgtct tttccgtcaa ttttaaaagt aactgatttt ggctttttat caccgtaaga 281641 ttccggcgta tagttaagct cgtattgctt gcctttatct acaacgaaga aaagatttcc 281701 ttcaacggat ttgtcagcgt taatcgtgct gccctgaagc ttttcgctat agtcttcagg 281761 gtctgtgtca gacattttgg tatcaccttg atacaatgtg aaatccatac tgtctacatt 281821 cagcgggtct tttcctgtgt ttttcaccgc gacattgact tttaacacaa gctggtcatc 281881 tgaagtggac ttatcatatt tagacggaag tgtgtaagag acatccttga ttttgacttg 281941 agctatatct gagctttttt ctgtttctga ttctttcttc tccgcgcttg ttttgctgcc 282001 ggaacaagca gctgtaaaca tcatcagcag aagaattagg aaaacagcgt acgttttttt 282061 ctgaaacatt catttttcct cctcaaatgg tttaggaaag gggagtcttt tgtctttgag 282121 aaatggatct ttttgaatgg attagcatca tataaccaaa aaaatcagtt cttttctcac 282181 ggttttcacc ggattttctg gaaactccgc cctcctttgt catgaatgga cctataaaaa 282241 gttacaacgg aattaatttt aagattatta gcttttatat tgaataggtt catcatccta 282301 tttttggtga aaaatgttct ggtaaaactg gtaaactcag aaaactgtgt attttagact 282361 attacttttt gattagttgg agggaactta agaaggatga aaggggccgc ctttgtgaag 282421 aaagagggac tgaaacaaaa agcactggaa atcggccggg tgccgacaca cttaaaactg 282481 gaaattgaag attatggcgg tgatgataaa agagctcatt tttgttgggc agatcctcag 282541 gatgagaata ccggcattat cgtggagctt ggaccggacg gagagctgga atccctttcc 282601 cgtgatattg agcctgaaag cggagaaagg ctgtctgagg agaaactaga ggatatcatg 282661 cgccaatttg tcgagactca tcatccgggg gcactctctg cctttgttcg tgaagaaaat 282721 gaccgtgcat acggcgataa agtgagattt tcatatgttc aaatggaggc tgggcttcct 282781 ctccccatga gcggatttat ggctgatgtt tccttatcag gtgagattgt ttacttccgt 282841 tattacggcg aagcgggcag catcatcaag ccaaagcggg tcgcggatgt tgaagaggca 282901 cttgccttta tcaagaagga cgtggagttc gaccttttgt ttgaggttct ccatcgttct 282961 gtttacaaaa acggagatga tcagccgcat ttggtgtacg agcctgaagg tagggcgatt 283021 accgtacctg cggatttggt tcaagaagaa caagcagttg atgatgacga tgattacagg 283081 gagccggaga gctttcctct ccctttattc gagggcatcc gcgaaaaggc cgatcctgac 283141 agcatgattg gtattgaaaa tgggtttgtc aaagagcggg aagcggattt gggagatggg 283201 agaattggaa tcgtttggcg gaatccggat gaccctgtgt atcagccggc ggataaaagc 283261 atggacagct ggtttaaggg acggactcat caagtgctga aaaccatcta taacaaagaa 283321 accggaaaac tcgaaggcgt catgtcattt atggagaaaa aagggccgct gacagtaacc 283381 ttggcagagt gtgaaaaaat cgcgcttcgc tttctatttg ctttatttcc gaatgccgat 283441 caatatttta ggatcagata cgacgaaaaa gatgaagaag aaaacgcagt cgctggtttt 283501 acgtttgaag cgcattgtca cggagttccg ctccgatttg ggcagatcag aatttgtgtc 283561 agccgccaga cagggtatat caccgtttat atgggaccgg atattgaccc aaataagctg 283621 gcaaccattg atcctgtgcc ggctatttca gttgaacaag ccaagtctat cttttggcag 283681 cattttaaag ttgagcttgg ctgggaaaga gagtacgggg atgatgaaga acacagctac 283741 cggctcgtct ataagccggt gtatccgcat tttatcgatg cacatacagg ggagcctgtc 283801 ttcagcatat ggtgaaacag ccaaaagtca cgcaattgcc tcagatatag aagagagtat 283861 gtgatgaaag taacagaaag aatctcaaaa aacaatgaca ataatagaaa aggacctttc 283921 ttcactttaa atgaagaaag gtctttttat ataataaaca ggattctctt tgtcgtagac 283981 tctttgaaag ggatgacttc attggttaat aaacagctga aaaagaaggc gcaggagatc 284041 ggaaatgtac cgacgcatta tgagcttgag atagaagatt acgaccaaaa gcaaaagaag 284101 tacgggcagg catattttat ctggaaggac cctaaagatc cggaaaagca cattacagtt 284161 gaacttagaa atgacggcgc cttgctcacc ttttcaacaa ctgtccactc cgagacagac 284221 aaaaaacttc cagatgccga gctgaagctg acggctcttc agtttgccgc tgccaatcat 284281 cccggcacat ttatgaattt tcattttcaa ggcaaggaag aaagggggca gcacatccgg 284341 tttgtctata ccaaaatgga gctggggctt ccgattccca attcaggctt tttaattgat 284401 atgacacgaa gcggtcagat tgtccacttt ctatattacg gggaagggca taaagccgaa 284461 gttccgacgg aatttgtagc aaaagagaag gttgtatccc attacttaaa cacaatgtct 284521 tttgagctga tgtacgatgt cattgatggc gaacaggaac caaggcttgt atatgaaccg 284581 attctaccgg gatacagcta tcccgcagat gtagacgaaa ttgtgcccga ccagcatatc 284641 gcagatgaaa gaatagaaaa cacggcgcca ctgccgccgc ttcagaacaa ggaagaagtt 284701 gatatatttg ccttgctggg ttttacctct gatatgcaga aagtcagtga aagagacttt 284761 ggagaacaaa ttggaagcac gtggcgcagg ggcgctgcgc cggagcgtaa ggatttaagc 284821 ataggaagct attttgaaac gagaaataaa aatacaatca aaatgaagac ggataaaaga 284881 accggaaaat taaaagcagc gctttctttt atggactggc ggaacaacct ccaatgctcc 284941 acggaagaat gccaagagat agcgcttcaa tttttgtatg ccctctatcc gagagcggct 285001 gagtttttca gggtgaatcc cgtccgaatt gatgaaagag ggagagtccg caaccatttt 285061 tctgtctggt ataaaggagt gccgctgcgg ttcggcgctg cccgcatcat tgtcaatccg 285121 gaaactgggt tgattgacgc ttttatggcg cctgatattg aacctgaaca attggaagcg 285181 ataaatcaca ggccggatgt ttccgctgaa gaagcgaaag aagcattttt agccgctttt 285241 gatgtgaaac tggaatggca gcctgatttt acagcaggca gtgaccagca ctgcaaactt 285301 gtctataagc cggtttaccc ttcctatatt gatgcgcaca taaggaaaaa gaaaaggctg 285361 tgaggggtgt ctagttagga atcatctcca agtgggggta gtccttgaat cgtttccaat 285421 ccccgcccca ttcgaaaccg agtgtcttag cgatctcgac aacctccagc caatctgatt 285481 ttccgttttg attgccgtca tattccatat cccatatgat gctgccatcc tttttttgaa 285541 gggcgaaatc aatcgctaaa ccatagttat gatacgattc ccctcctctt gcataggtga 285601 caatattccc tttttttgta cgtccctgtt tatataattc atcttgttcc ttaaaggacc 285661 tgaatccttc agtaatgacg acgtcaatgc ctttattcgc tgcagcggct ttgagtgcat 285721 cggcattctg cttcacaatc ggatgaagat ccgaggggac aggcatgtcc tgcaaggcgt 285781 tttgagaatg ccattcatgc cgaatataac taaaacaaag atctagaaga aatagaatac 285841 ataagataac aaatgttttt gcgggtaagt tcatatcggt ctcactttct caagatgtgc 285901 tgaatgttaa cgcttttaag tgattgactc tctctaaaag cgaacagcta tgataaaata 285961 taacataaat agtagcagga ggaaggaggc agaccgatga gagcaaagat tccatcagaa 286021 gaagtagcag taaagctgaa tgaatggtac aagctcattc gcgcatttga agcagatcaa 286081 gcagaagcgt taaagcagga gattgaatat gatttagaag atatggaaga gaatcaggac 286141 ttgcttttat atttttcttt gatggaattc cggcatcgaa tcatgcttga taagctgatg 286201 ccggtgaaag acagcgatac caagcctccg ttctctgata tgctgaacga aattgaaagc 286261 aatcagcaaa aactcacggg cttactggaa tactactttt attatttcag aggaatgtac 286321 gaattcaagc agaaaaattt catattagcg attgaccatt ataaacatgc cgaggaaaag 286381 ctcgagtatg tcgaggatga gatcgaaaaa gctgagtttc tttttaaagt cgcagaagtg 286441 tattatcaca tcaaacaaac gtatttttcc atgaattatg cgagccaggc gcttgatatc 286501 tatacgaaat atgaactgta cggtcgccgc cgggttcagt gtgaatttat catcgccgga 286561 aatttgaccg atgtgtatca tcatgaaaaa gcactgaccc acttgtgcag cgctttagaa 286621 catgccaggc agcttgaaga agcgtacatg atcgctgctg cctattataa tgtcggacac 286681 tgtaagtaca gtctgggtga ttacaaagaa gcggagggct atttcaaaac agccgccgcc 286741 atttttgagg agcacaactt tcagcaagct gttcaagctg tattttcact gacccatatc 286801 tactgtaaag agggaaaata cgacaaggca gtagaggctt atgaccgcgg gataaagagc 286861 gcggctgaat gggaggatga catgtacttg acgaaattcc gcctcattca tgagctgtat 286921 cttggaagcg gcgacctgaa cgtgcttaca gaatgctttg acctgctgga atccaggcag 286981 cttcttgctg acgccgaaga tctgctgcat gatacagcgg aacgtttcaa tcagttggaa 287041 cattacgagt ccgccgcttt cttttaccgc aggctgatga atattaaaaa gaagcttgcc 287101 gagcagcgtt ttcaatagga aatggcagag aactacaggt tctctgcttt ttttgtgctg 287161 ttttcaactc ggaaaaacag ggtattttcc actgcatagt gagaaacaga ggaggatatc 287221 aagtatgtac aaagatttaa ccggaaaaac agcgattgtg acagggtctt caaaaggaat 287281 cgggaaagcc attgcggaac ggttcggaaa ggagaaaatg aatgttgttg taaattacca 287341 cagcgacccg tctggagcag atgaaactct ggaaatcatt aagcagaacg gagggaaagc 287401 cgtctcagtt gaggcggacg tgtcaaaaga agaggggatt caggcgctct tggacacagc 287461 tttagagcat ttcggcacgc tcgatgtgat ggtaaacaac tccggtttta acggcgttga 287521 ggcgatgccg catgagatga gtcttgaaga ttggcagaga gtgattgatg tcaatgttac 287581 cggaaccttt ctgggagcga aagcagcact taaccacatg atgaaaaaca atatcaaggg 287641 caatgtgctg aatatctcaa gtgttcatca gcagattccg cgccctgtaa acgttcagta 287701 ttccacatcc aaaggcggca tcaagatgat gacggaaacg ctggcgctca attatgcgga 287761 taagggaatc cgcgtcaatg cgatagcgcc cggcaccatt gccacagaat caaatgttga 287821 tacgaaaaag gaagagagca ggcaaaaaca attgaaaaaa atcccgatga aagccttcgg 287881 aaagcctgaa gaagtggcgg cagcagcagc ttggctcgta tctgaggaag caagctatgt 287941 gaccggcgca acacttttcg tcgacggcgg aatgacactt tatccatctc agcttgaata 288001 gaagacaaaa cagggggatt gcgggatgaa aacagactgg tggaaggatg cagtggtgta 288061 ccaaatttac ccgagaagct ttcaggacag caatggagac ggaattgggg acttgcgggg 288121 gattatttcc cgtcttgact acataaagga gctcggggca gatgtgattt ggatttgccc 288181 gatctatcct tctccgaatg ttgattacgg ctatgatgtg acaaaccata aggcgattat 288241 ggattcttac ggaacaatgg acgattttca cgagctgctg gaccaggtgc atcagcgggg 288301 attaaagctg gtgatggact ttgtgttaaa tcacacctcg gtcgagcatc cgtggtttaa 288361 agaagcggag ctggacaaaa acagcaaata ccgtagctat tattattggc gtcccggcac 288421 aaagaacggc ccgccgacgg actggctctc aaactatgga tgcccggtct ggcaatacga 288481 agagcacacc ggagaatact atctccatat gaatgccgtc aaacaagctg atttaaactg 288541 ggaaaatccc gaagttcgcc aggcggtgta tgacatgatg aaattttggc tcgataaagg 288601 ggtcgacggt ttgcgaattg atcagctcca tctcatttct aagaaagaat atcttccttc 288661 gtatgaggac tatatcaatc agcaggcaga gccgaagccc tttcagccaa atggcgaacg 288721 aatccatgac tatttaaaag aaatcacaga tgaagtgttt tctcattatg atgtcatgtc 288781 tgtcggagag gtcggcagtg tcacaccgga agaaggcctg aaatatacgg gaacagataa 288841 gcatgagctg aatatgattt ttcactttca gcatatggag cttgatcagc agcccggaaa 288901 agaacattgg gatttgaagc cccttgagct ttctgattta aaatcggttt tgacaaaatg 288961 gcaaaagaag cttgaacatc aaggctggaa tacattgttt tggtgcaacc acgaccagcc 289021 ccggattgtg tccagattcg gagacgatgg ggaataccgc aaagcatcag cgaaaatgct 289081 ggcagccgta atttatttta tgaagggcac gccgtatatt tatcagggag aagaaatcgg 289141 gatgacaaac gcgccgttca cccggattga agactacaaa gatatccaaa cgatcaatat 289201 gtatcataaa cgggtgtttg aaaaaggcta tgatccaaat gatgtgatga gatcgatctt 289261 agccaaaagc cgggatcacg cccggacccc gatgcagtgg aacagcggca aaaatgccgg 289321 atttactgac ggcacgcctt ggctgaaggt caatccgaac ttcaccgcaa tcaatgtgga 289381 ggaagcgcag ggagatcctg attctgtctt aaactattac aaaaagctga tcagcctgag 289441 aaagcagtac gctgacctca tgaaagggag ctttgatctt ttgcttccgg acgatccgca 289501 gttgtttgta tacatgagag aaaacagtaa acaacagctt ttgtcggtca ataatttttc 289561 aaaagagcag gctgtttttc agtggcctaa gaactgcggc aaagctcagg cctcactgct 289621 tctcagcaat tataacaacg atgatcttga tgacgaaatg gtgttccggc cttatgagag 289681 cagggtctat cttctggaca aaacaaacta atgattgaag tagcccggca tttttagccg 289741 ggttttttta gtacatatat tcgctctgca ggcgggaaga ataaatgaaa atgaaattta 289801 ttcttgcaaa acgtaatgac ttcggtttat tatgatatag gattacaaaa tcgttatcat 289861 tttgatttaa agttactgaa aaagagggga tatacgatat gtttaaaaaa tggagcggtt 289921 tgtttgtgat tgcagcgtgc tttttattag ttgcagcatg cggcaactca tcaacaaaag 289981 ggtcggcgga ttcaaagggt gataaactgc acgttgtcac aacgttctac ccgatgtatg 290041 aattcacaaa acaaattgta aaagacaaag gcgatgtgga tctgttaatc ccatcttccg 290101 ttgaaccgca tgattgggaa ccgacgccga aagacattgc caacattcag gatgctgatt 290161 tgttcgttta taatagtgaa tacatggaga catgggttcc gtcagctgaa aaaagcatgg 290221 gccaaggcca tgccgttttc gttaatgcaa gcaaaggcat tgatttaatg gaaggctctg 290281 aagaagaaca cgaagagcat gatcatgggg agcatgagca cagtcatgca atggaccctc 290341 acgtatggct tagccctgtt ctggcacaga aggaagttaa aaatattacg gctcaaatcg 290401 tgaagcagga cccggataac aaagaatact atgagaaaaa tagtaaagaa tatattgcaa 290461 aactgcagga tcttgataaa ctatatcgta caaccgcaaa aaaagcggag aaaaaagaat 290521 ttatcacgca gcatacagct tttggctatc tggcaaaaga atacggcttg aagcaggttc 290581 cgattgcagg gctttcacct gaccaagaac cgagcgcagc cagcttggca aagctgaaaa 290641 catatgccaa agaacataat gtaaaagtta tttactttga agaaattgca tcctcaaagg 290701 tcgcagatac gctcgccagt gaaatcggcg cgaagacaga agtgctgaat acactggaag 290761 gcttgagcaa agaagaacag gataaaggtt tagggtatat cgacattatg aaacaaaacc 290821 tcgatgccct gaaagattca ctattggtta aatcataaga tagtgtgcgc cggaggggtg 290881 cacactattt ctttgtgaga aaggaagatt aacatgaatc tcgtctcatt gaaagatatc 290941 gttttcggct attcccatac gcctgtttta gataaagtat cacttgatat tgaaagcggt 291001 gagttcgtcg gcatcactgg accaaacggc gcctctaaat cgacgctcat aaaggtaatg 291061 ctcggcatgc tgaaaccgtg ggaaggcaca gtgacgatca gtaaaaggaa tacagaaggg 291121 aaacgcctga ccatagggta cgtcccgcag caaatttctt catttaatgc cggatttccg 291181 agcacggtgc tggagcttgt tcagtcaggc cgctatacaa aagggaaatg gtttaaacgt 291241 ttaaatgaag aagatcatct tgaagtagaa aaagcattga aaatggtgga aatgtgggac 291301 ctccgccatc gtaaaatcgg tgatttatca ggcggacaga aacagaaaat ctgtatcgcc 291361 agaatgctcg ccagcaaccc ggatctgctg atgctggacg aaccgacgac agctgttgat 291421 tacgacagca gaaaaggatt ttacgaattt atgcatcatc tcgtgaaaaa tcacaaccgc 291481 acagttgtga tggttactca cgaacaaaac gaagtacagc aatttttaga taaagtgatt 291541 cgattagaga gaggagaaaa aggcggatgg aaatgtttga cttggaattc atgcgacgag 291601 cttttctagc aggcggcatg atcgccgtca tggctccgat actaggagtg tatctcgttc 291661 tcagaagaca ggccttaatg gctgacacac tttcacatat ctcattgtca ggtgttgcca 291721 tcggcttttt tctcagcacc aatataaccg cagcaagcat agtcgtcgtg accatcggcg 291781 cgatcggaat tgaatacatg cggcgggcgt atcggactta ttcagaagtg tccattgcca 291841 tcttaatggc agctggtttg tccttcgcga tgtttttaat cagcctttcc aaaggcacag 291901 ccaatatgag catcgatcaa tacctatttg gatcgcttgt gacagtaaac cagcagcagg 291961 tctatattat cagtattatc acactgctga tcctgcttta ttttattgta ctgagaaggc 292021 cgctctacct gctgacgttt gatgaagcta cagccaaaac atcgggaatc aatacaaacg 292081 ttctctcgtt gtcattcagt attgtcacag gccttgcgat ttcagtcatt attccgatca 292141 tcggggtcct tcttgtatcg gccctgctcg tattgccggc agccttcgcc atcagaattg 292201 caaaaggctt taacatggtt ttcattacag ccatactcat ttcattattc agcgtattta 292261 cgggactgac atcatcctat cagctcggga cgccgccagg tccgtctatt accctgctat 292321 tgatcgtttt gctattaatc ggatttgcag ttcagggagt ttggacgttt atcaaaaaag 292381 aagctcagcg caaaaaaaga agccgataac atgaaaagca gttttcccta gggaaaactg 292441 ctttttttat agaaacaatt cggcaaggcg ctcataagat tcttttttcg cctcaaaatc 292501 aaacacattg cacagaacca tgatttcatt tgtttcgtag cagcctgtga ggtctaacag 292561 ctgttgtttg acagtggtgg gagaaccgat caccatccgc tttctgtttt cttctatgag 292621 ttttttatcg gacgctgtat agggatgagc tttcgcttcc tcgatgcttg gcacgcggct 292681 gtccaagcct tttccgacgc gaagaagcca cagatcctgg cttaatgcga gttcttctgc 292741 ctcttcatct gtttttgcgc aaatgacaaa aatcgtaaac agtgcggatg gattcgaaaa 292801 atgggctgag ggccgaaagc tttcccggta gatgcggaat gcattttctc ctcgctcggg 292861 attaatgaaa tgcccaaata catatccaat cccctggtgc gccgcgcgtc ttgcgctgtt 292921 ttcaccaaga ccgagcaccc atagctcggg tgccgtacca ataaggggcg ccgctttgat 292981 tccggcatac ggatggtcgg gaggaaggga atctgttaga aaataagaga catcctgcag 293041 ctgtctgtta aattcggtta agcttttttt caccccgtcc gttaatgcaa gtctggtttt 293101 tgtcgtgccg ccgggggagc gaccgacgcc gaggtcaatc cggtttggat acagggcctc 293161 aagctggcga aaggtttcag ccactttaaa tgggctgtat tggggcagaa gcacgccgcc 293221 tgatccgaca cgaatggtgt ttgtctgtgc tgcgatgcgg gcgatcatga tttcaggcgc 293281 tgtgcttgcc agtcctttcg tgctgtgatg ctcggcaaac caataacgct tatagcccca 293341 ctgttcgctt aattgggcaa gctcaaccga atgctggaga gttgtcacag ggctttctcc 293401 tttagaaaca ggtgcctgat caagtatgct taaatgaatc aaaaggccgc ttcctttctg 293461 tctgttttta gatggtgaca ccagaatagg caaaatgact tgcccgcgtc aaatggtttg 293521 tttaagaagc gcactttata gcatttgcaa atcatatatc aaatatggaa gttttttttc 293581 gaggtttttc gtcaattatt cttaactttt acgaaacttt gatataataa caaacgtata 293641 tattagtaat ttacggctta ttttccttgt gagcgtaaaa ataaatgtga ctatcttcac 293701 attttgatga gtaggagtga atcgtgtggc aatttcttta gaaaaaggtc aacgaattga 293761 tttaacaaaa ggaaaagccg gtctgtcaaa attgatggtc ggtctcggct gggacccagt 293821 gtcctcaggc ggaggattct tcagcaaact gcttggcgga ggcggtccga atatcgactg 293881 tgacgcttca gtgctgatgc tggaaaacgg aaaattcacc gataagaaaa acctgattta 293941 tttcggcaac ctgaaaagcc gctgcggcgg tgtacagcat acaggcgaca acctgacggg 294001 tgacggtgcg ggcgatgacg agcaaattat gatagattta gataaagtgc ctggaaacat 294061 cgataagctt gtatttgtag tgaacattta cgattgtgtc agaagaaaac aagatttcgg 294121 catgattcaa aatgcgttta tccgcgtagt tgatcaatct aatcacgagg aaatgctcaa 294181 gtacaatttg agagacaatt acgccggcag aacaagcctg attacagcag aaatctaccg 294241 cagcggcagt gagtggaagt ttgcggcggt cggtgaaggc acaaacgata cgagattaga 294301 agatattatc agtcgatacg tataaaagaa aaggagtgga tgaaacatga caatttcatt 294361 ggcaaaagga caaaaagtag atttaacaaa aacaaatccg ggtctttcaa aggttgttgt 294421 cggtttaggc tgggatacga acaagtatga cggcgggcac gactttgatc ttgactcaag 294481 tgtgtttctg ttagacgccg cgggcaaatg cgcgtcacca aacgacttta ttttctacaa 294541 ccagcttgaa ggcggcaacg gttcagtcgt tcattcaggc gacaacctga ctggtgctgg 294601 cgaaggcgac gatgagaatg taaaagtaaa tctcagcgct gtaccggcaa acattgataa 294661 aatctcattt gttattacca ttcacgatgc agaagcgcgc agccaaaact ttggacaagt 294721 atcaaacgcg tttgtccgca tcgtaaatga agaaacaaat gaagagctca tccgttacga 294781 tcttgcagaa gatttctcta ttgaaacggc aatcattgca ggggagcttt acagacataa 294841 cggcgagtgg aaattctcag caatcggctc aggctaccaa ggcggccttg cccgcattgc 294901 aacagactac ggtttgcaag tcggttaaga caaatacgaa gagcagaaag gagagaggca 294961 gtatggccat tcaattatca aaaggacagc gcattgattt aacaaaaaca aatccgggac 295021 tgactaaagc ggtgatcggc ttaggctggg atacaaacaa gtactccggc ggacacgatt 295081 ttgacctgga tgcttcggcc tttttagttg atgcgcatga taactgcgta aatgatctcg 295141 atttcgtctt ctataataac cttgaacatc cgagcggcgg tgtcatccat acgggtgaca 295201 accgcacggg tgagggcgac ggagatgatg agcagattat cgttgatttc tcaaaaatcc 295261 ctgctcacat tgagaaaatc ggcatcacag tgaccattca cgacgctgaa gcacgcagcc 295321 aaaactttgg acaagtttcc aatgcatttg tccgcgttgt ggatgaagaa acgcagaatg 295381 agcttcttcg cttcgatttg ggagaagact tctccattga aacagctgtt gtcgtttgtg 295441 agctttacag acacggcggc gagtggaaat tcaatgcaat cggcagcgga ttttccggcg 295501 ggctggctgc attgtgccgg aattacggtt tgcaagtgta agcgagtgac aaatagagaa 295561 gtcaccgttt caaattatag gaggaaaaaa cttggacttt ttacatcata ttttgtctac 295621 gtatgcttca tttttcgatt ggaaaatgtg gggggaagtt ctgactgatc ctgtttcctg 295681 gggtttgatc ggttcccttg ttgttctgga aggcctttta tcggccgata acgcgcttgt 295741 tcttgcggtc atggttaaac acctgccgga aaaacagcgg aaaaaagcgt taacgtatgg 295801 tttgtttgga gcttatattt tcaggtttat tttcatcggg ctcggtatgc ttctcattaa 295861 attctggtgg atcaaggtgc ttggcgcgct ttacctggct tggctcgtca ttaagcactt 295921 ctggataggc gaaaaagaag aggaagcgga cggcatgaag aaaaactctt ggatggtccg 295981 cacgttcggg atcttctggg cgactgtcat ttcagtagaa ttaatggatc ttgccttctc 296041 tgtggacagc atcctggccg cgtttgcagt atctgaaaaa gtatgggtgc ttctgattgg 296101 cggtatgctt ggtattttaa tgatgcgtac agtggcaaaa gtgttccttg tgctgattga 296161 taaaattcct gagctggaaa acacagcatt cgtcttaatc ggcattatcg cgctgaaaat 296221 ggcggggagc gctttccatt acgaaatgcc gcactctgta ttcttcatta tcattatcgc 296281 tgcatttgcg gtaacattga tcattcacta catcaataaa caaaagcagg tgcgcgaaca 296341 aacagccgct tcaaaagaag aataaaacaa aacaaggagg gaggttcaat gtccttcctt 296401 ttttgttacc gaaatatcgt ttcaatgaca aaccggaaag gaggatatga tgagacaaga 296461 agaactaacc attcataaag cacttccggc tgatggcgat tggaaaagcc tgctgtttca 296521 gccattgccg gagcgggatc actatgaaac tgcacaaggc ctttcttttt ctcgtcttgc 296581 cggtcagata ttgggcacgc ctattgatga gacggactac tataacgagc tgtatgagct 296641 gtctgtaaac gaccgcataa cgattttgag tgaaacgctt gataaaacaa tcgaaccgga 296701 aacatttcaa aagcttcagc atattcattc catcaatcag aaagaaaaag ggctgtcagt 296761 cagccgcttt gttgcctttc tggacgggga aaagctgatt gcgaagcact caaatccctt 296821 gatgcaccgc catttaagaa aagcgttgat gacgctttta catacctttg cggacagtca 296881 tgaaaagggg ctgaatcatc ctgattttcg cagagtgctg cttgatgtct cgaagttttc 296941 cttaaaccat ctgaaccctt ggctggaaaa aaccgatata gagcgggaga tgccgaaggt 297001 tgtttggtat ggagatgcga cgaaaagcca gctctatttc ttatattatc tgatgctggt 297061 cggctgtgat gtactgctgt tccatccggc gggaacggat cagctggcgc ttgtcgaccc 297121 gaagcaggag ctcggtttta cggaaaagct cccggatgtt tcggagcttc agccgtttcc 297181 gaaagaaaaa ccagaccgga aatcaacagt ggcttaccgc tcaacaaagg aaattgaaca 297241 tgtgctgaat cacgaggaat ccatgctata taagccgtgg cagttcagag atcacacacc 297301 ggtgtccgtt acgctgaaaa cgacctatga tgaattgttt ttaatcacga aagaacgcgc 297361 ctttattcgg ccgaatttca aagctgataa acattccatt gagattccga atgtattcgc 297421 caaaattatg ggcgtgtcga aagacaataa ggaatattgg aacaggcttc atactctagc 297481 ggattatcag gaaacagaaa tggtcagaag ctttccattt acagaagaaa taaagtcgaa 297541 ctatcaattt cactacagcc acgcacttga tcaagaaggg aacattgatc cggacaagct 297601 gatggcaagc aatgtgtggc agtacaaaca gctgccggcg ggcgttcaga ctgccattgc 297661 caaaacgatt tcgagaatgt gcaggtaccc gcggcttaaa gccttgcatc aggaacaagt 297721 caaggatgtt caaatctatt tgtttaaaca aacaacaaac ctgcctgcta atctgctgaa 297781 attgattcaa atgttcgact atgcgcaaac cgttccgaaa ctcgttttat atcatacgga 297841 aatgagcggc ggactcacgc gttcggatgc tgccgccctg ctgttcctga atgaaatcgg 297901 aatcgatatc atcatttata atccgcccgg acaccaagat attgagcagt ttattgaaga 297961 ggatcagtat gatatccact ggctggatga catggtgttt cagcaggact acaaagagcc 298021 ttcgcttgtg aaaaggctct tcagaaccat tacccaaaaa taaggagaga agaaaagcat 298081 gacaacagaa aatcaaaatc cgcttgttct cgataaaaat gaagagattt cccagcaaaa 298141 agctgacgat atccgtcttc agctccgtca ggaaccagaa gtgaagcggc ttgctcaaca 298201 aattgacgtc aaaaaccaaa tggagctgct tgagtacggc aaggagccgg ccgttgaaat 298261 atccaagttc tctgaccgca tcttggggat gatgaaaaca acaagcgtga cagactccgg 298321 cacaatgctg actcagcttg ggaaaatcat ggaccgcttc gacaaaaatg attttgatga 298381 gccaaaggga ttaatggcga aaattttcaa acgcggcggc agcatgattg aaaaaatctt 298441 taaaaagtat cagacgcttg gcggagagat tgaaaaaatc cacgttgaga tttcaaaata 298501 caaagatgag atgacgaaga cgaactacac gctcgatgaa atgtatgaaa acaatatcaa 298561 atactatatg gagcttgaaa aatacgtcgt tgccgggcag atgaaactgg aagagatgca 298621 gtcgatcctt ccttcatatg aggaaaaagc ggcaagcggg aaccagctgg cgcaaatgca 298681 gctcgatacg ttgcgcaacg gcattcaggc gcttgaggaa cgggtgtatg atcttgacat 298741 ggcacggatg gtggcgcttc aaaccgcacc tcaaatccgt ctcctgcagc gaggaaatgc 298801 aaagctgatc gggaaaatca actccgcgtt tatcattacc attccgattt tcaaaaacgg 298861 cattattcag gctgttacgg taaagcggca aaagcttgtg gctgattcca tgagcgagct 298921 tgaccgccgg acaaacgaga tgctgaaacg aaatgctgaa aacatctcga gccaaagtgt 298981 tgaaattgcg agaatggccg gcagaccgag catagatatt gaaacgattg aatcgtcttg 299041 gaacacgatt gtcagcggca tgcaggaaac aaaacaaatc gaagaagaaa acaagcgcct 299101 ccgcgaagac ggcgcgagac gaattgccca gcttcaggat aatattaaaa aagcagcatt 299161 gcagcaataa taaaaacccc gcttgtggaa cataagcggg gtatttcaat tacatcattt 299221 agttaatgac aatgtgtaaa gacaggtgta aacttaaacg gtaatcattt tgcatatcag 299281 aggtgttggc aatgggaaaa caacagccta tatcccagcg taaactgctg ggcgtcgccg 299341 gtttggggtg gctgtttgat gcaatggatg tcggaatatt atcgtttatt atcgccgcgc 299401 tccatgtaga gtggaatctg tcgcccgaag aaatgaaatg gatcggaagc gtcaattcca 299461 tcggcatggc tgcgggtgcg tttttgtttg gtttgcttgc tgatcgaatc ggccgcaaaa 299521 aagtgttcat catcaccctt ttatgctttt ccatcggaag cggcatttcc gcttttgtga 299581 cgagcttatc ggcatttcta atccttcgtt tcgtgattgg tatgggactt ggcggcgagc 299641 ttccagtcgc ttcaacactc gtttcggaag cggttgtgcc tgaaaagcgg ggcagagtga 299701 ttgtgctttt ggaaagcttt tgggccgtgg gctggctcgc agcggccttg atttcttact 299761 ttgtgatacc aagcttcggc tggcaggctg cccttctgtt aactgcgctg actgcttttt 299821 atgcgctgta cctgcggacg agtctacctg attcgccgaa atatgaatcg ctttctgcca 299881 aaaagaggtc gatgtgggag aatgtaaaaa gcgtctgggc aagacagtat atacggccga 299941 cggtgatgct gtcgatcgtt tggttctgtg tggtgttttc ttattacggc atgttcctat 300001 ggctcccgag tgtcatgctg ctgaaaggct tcagcatgat tcaaagcttt gaatatgtcc 300061 tgctgatgac gcttgctcag ctacctggct atttctctgc cgcatggctg attgaaaaag 300121 cgggccggaa gtggatactc gtcgtttact tgattggcac agcaggaagc gcctatttct 300181 tcggaacggc ggattcctta agtcttctgc ttacggctgg agtgctgtta tcgtttttca 300241 atctcggtgc gtggggcgtg ctgtatgctt ataccccgga gcaatacccg actgcgattc 300301 gagcaacagg ttcaggaacg acagcagcgt ttggaagaat cggcggcatc ttcgggcctt 300361 tgctcgtcgg aaccctggca gcccgtcata tttcgttttc ggtcatcttt tcaatctttt 300421 gcattgcaat cttacttgcg gttgcttgta ttttgattat ggggaaagaa acgaaacaaa 300481 ctgagctaga ataggaaaag cacctcttaa aagaggtgct ttcagcgtgt cgacaaaccc 300541 tcgcattcgt tgtcaggact gcgcttcggt gctcaatgcg aagtggatca acggctaaat 300601 tctcaggcgt cctgcctaaa cgccgtcgtc atcacatcct gtgaatgtcc gctcctatgc 300661 tcgtccttcc tagacttcaa gggttttcaa tcacgctgaa aagattttgt caacaatctg 300721 aggcacctct tgaatgaggt gcttttttac aattgcgccc gggctgtgga ttggcgtttc 300781 ccggttttac tgattgtctg gtagagcgtc atagaaagta tgaacagaat ggcagtaaat 300841 cctgtgacag ctccgaaatg ctgtgtgctt tgatataaaa aacctgcaat acttgtaccg 300901 acagtggttc cggcatacat agcggcattg gaaagggaag cgatggttcc tcgcgcattt 300961 ggtgcaatgg attgaaagac acccatcatt aacggaaaga tgatgccagc tgtaaagaac 301021 gtgagaaaaa agccggcttc tactaaaaac aagtttggaa agaacggaag agcgaaatag 301081 agagcgccca ttagcagcat cccgctgatc agtgttttaa acatgcccag cttttctgaa 301141 acccggctgc cgataaggct cccgagcata tttcccagtc cgagtacaag catagctgcg 301201 ccaatttgtg acacggttaa atgataatcc gcggaaagcc aagtacccag aaagctgaac 301261 gatgcgaagt ttccggtttg aaacagaaaa taggcaagca gaatgaccga tgttttcggc 301321 aatgaaaaaa gctcccgata ggggttgaca attgatgggc gcgccaatgg ttcagaaggc 301381 cggatgccag gcatgaccgc cgccaggatc aatagaagaa taagcgagca cgctgacaaa 301441 acgaaaaatg gcgtatgcca tgtaaaggaa gcgagaaacc ctccaatagg aagtccgagc 301501 atttgtgaag cggccaaacc tgctgtcgca atccccatgc cttttatgat ctgagaaggc 301561 tggacaatga ctgggatgga cgcccaaatt tgaggcgtca caaacgcagc gctaacgcct 301621 gcggcaaaac ggaacaggca catggcggca aaagagggag cgatgccgca taaaaatgtg 301681 gatacgataa agcctgcaag tccccacagc atgactgttt tcctgttcag ccggtctgag 301741 attgggcctg caatgaaagc gaagagtgca taaccgagtg cataagcact gaccatccag 301801 cctgacaaat cagtagagac atgaaactga tcctgtaaaa gggggagaag cggcgaaagc 301861 aaaaaggtat ccgtgccaat gacaaacatg acactgaaga aaagccaaat gcgattcaaa 301921 ttttatcact cctattgttt tataacttta aaactatgaa acagatatgt atagagaaaa 301981 ccctttgtta gagggtttcc aaaaagccag gcaggtatgt ttgaaatgtg tcttcacgca 302041 gactgacgta ttttgtccgc gaatctttcc gggttgccgt caatcccgct tcacgcagcg 302101 ttttaaaatg ataagatgcc gtggttttga caatattgca cttttcacct acttcaccgc 302161 agctgagttc ttttccgctg acataaagcg tacgaataat ggcaagcctt gattcatcag 302221 acagtgcttt aaaaatttgc gctctgattt gatcatctga ttgtttcata gtcatgaaac 302281 tataatacat aatgggtgtt gaaaaagcaa cttatttttc cagtaaagga gcaggaagtc 302341 ataagaggaa ggaggaattc aattccaata aaagcgtttt caactaaagg taggagaaaa 302401 atcacccgta aaatacaatc atataggagg attacagagc atttagaagc ataaataaga 302461 tcatgtggtc acatggatgt ttataaagaa atggtacaga ataaaagaga atatgctgtt 302521 tgtgtgggaa gttacataaa tgttacggta ataaagattg cttaatatgg agggaaaata 302581 tgagtgtaga tgagaaacca attaagataa aagtcgagaa agtctctaag atttttggga 302641 aacaaacaaa gaaggcagtt caaatgcttg ccaacggaaa gacaaaaaaa gagatcctga 302701 aagcaaccgg atcaaccgtt ggggttaatc aggcagattt tgaagtatat gatggtgaga 302761 tatttgtcat catgggtcta tcagggagcg gtaaatcaac tttagtacgg atgttaaacc 302821 ggcttattga accgactgcc ggaaatattt acattgatgg tgacatgata acaaatatgt 302881 caaaagacca gctccgggaa gtccgccgga aaaaaatcag catggtcttc caaaagttcg 302941 ctctgtttcc gcacagaacg atacttgaaa acacagaata cggactggag cttcaaggtg 303001 tagacaaaca agagcggcag caaaaagcgc ttgagtctct taagctcgtt ggactggaag 303061 gatttgaaca ccaatatccc gaccagcttt ccggcgggat gcagcagcgt gtcggccttg 303121 cccgcgcgtt gacgaatgac ccggacatcc ttctgatgga cgaagcgttc agtgcgctcg 303181 atccactgat tcgtaaagat atgcaggatg agcttcttga tcttcacgat aatgtcggaa 303241 aaacaattat ctttattacg catgacttgg acgaagcgtt gcggatcggc gacagaattg 303301 tcctaatgaa ggacggcaac atcgttcaaa tcggcacgcc tgaagaaatc ctgatgaatc 303361 catctaacga atatgttgag aaattcgtcg aagatgttga tttgtctaaa gtcctcacag 303421 caggccacat tatgaaacgc gctgaaacag tgcggattga taaagggcct cgcgtagcat 303481 tgacactgat gaaaaacctt ggaatttctt caatttatgc agtggataaa caaaagaaat 303541 tattaggtgt tatctatgcg tctgatgcga aaaaagcggc tgagtctgat ttgtcacttc 303601 aagacatctt gaatacagaa tttacgactg taccagagaa tacgtatctg actgagattt 303661 ttgacgttgt gtccgatgcg aatattccaa ttgcggttgt ggatgagaag caaagaatga 303721 aaggaattgt cgtaagaggc gcgctgattg gcgcacttgc cggcaataac gagtatatca 303781 atgctgaagg cactaacgaa caaacacaag atccttctgc acaggaggtg aaataagatg 303841 gatagactgc ctagaatacc tttagcagat attattgacc gttttgttga ctggattacg 303901 atgacgtttg gcggattctt cgacggaatc gctaacggat tggccgcttt tgtaaatgga 303961 attgtcaccg gtcttggatt tattccatct attttgttaa cgattatttt cgccgcactt 304021 gcgtggtgga tcagtacaag gggaattgcg ttatttacgt tgattggatt cctcctgatc 304081 gattatttag gatattggga cccaatgctg caaacattgg cgcttgtttt gacatctgtg 304141 attatttcga ttgtggtcgg ggttccgatc ggaatttggg cgtctcagaa agaaacggtt 304201 cgccgtattg taacgccaat tcttgattta atgcagacaa tgcctgcttt cgtatatcta 304261 ttgccggcga ttttcttctt taacatcggt gttgtgccgg gtgttgttgc atctgttatc 304321 ttcgcgatgc cgccgacaat ccgcatgact gttctcggta ttaaacaagt gccggcggat 304381 ttgattgaag cgactgaggc attcggttct acaacagctc agcgtttgtt taaagttcag 304441 ctcccgcttg cgacaaaaac gattttggcc gggatcaacc agagcatcat gcttgcgtta 304501 tcaatggttg ttatcgccgc aatggtcggt gcaccgggac ttggttctga agtatacagt 304561 gccgttacac agctgaaaac cggggtcgga gtagaggccg gtatcgccat cgttatcgtt 304621 gccattaccc tggaccgtat tactcaaaat attaaagtga agaagaaaag cagggggaat 304681 gcctgatgct taaaaaaatc ataggcatcg gcgtttccgc catgctggcg ctctcacttg 304741 cggcttgcgg ttcagaaaac gatgaaaatg catccgcagc agaacaagtg aataagacca 304801 tcatcgggat tgaccccggt tcagggatta tgtccctgac tgacaaagcg atgaaggatt 304861 atgacctgaa tgactggaca ttgatttcag cgtcaagtgc tgcgatgacc gctacgctta 304921 aaaagtcata cgaccgtaag aaaccgatta tcattacagg atggacaccg cactggatgt 304981 tctccagata taagctgaaa tatctcgatg atccgaaaca atcttatggc agcgcagagg 305041 aaatccatac gatcacacgc aaaggcttca gcaaagagca gccgaatgcc gcaaagcttc 305101 tgagccagtt taaatggacg caggacgaaa tgggcgaaat catgatcaag gtggaagaag 305161 gcgagaaacc tgccaaagtt gctgctgagt acgtcaataa acacaaggat cagattgccg 305221 aatggacaaa aggcgttcaa aaggtgaagg gagacaaaat caaccttgcc tatgtggcgt 305281 gggacagtga gattgcaagt acaaacgtca taggcaaagt cttagaagac ttgggctatg 305341 aggtaacact tactcaggta gaggctgggc cgatgtggac tgcaattgcg acgggaagtg 305401 cggatgcatc cctttccgca tggctgccga atacccataa agcatacgcc gctaaatata 305461 aaggcaaata tgatgatatt ggcaccagta tgactggtgt gaagatgggg cttgttgttc 305521 ctcaatatat gaaaaatgtc aactcaattg aagatttgaa gaagtaatca aaaaagcagc 305581 ctgtgtcagg ctgctttttt tgcgttaaga agcgttagcg gcagcaagtg attccgcctt 305641 ctgaaatgtt ttgagcacgg cgttcgccaa aatatgaatg ccggtaaaca tcgcatttct 305701 gtcaaaggtc atgtgcggat gatggagccc cggctggagc ccgcagccta gtccgagcat 305761 cgttgttttc agattcggca ccttcacggc gtaaaaatgg aaatcctcgc cgccggtggt 305821 gacaagcggg tcatcaagcc gctcagcccc gatgatttcc gtaatggctt ctgccatgat 305881 cgcttcagct tctttatttt gtgttgccgc aggaaggctg tgttctttgt gcagctcgat 305941 ctttgcgcca aatgcagcgg cggccgcttc acaggctctt tctgtttcgg cgattaatgc 306001 ctccatggct tcattggtct gtgcgcgcaa atcaaggctg aacgatgctt ttcctggaat 306061 gatgttagag ctttcaccgc cggcttgcag ttttgtcatt ttgacggtat gcgggatttg 306121 cgggtcaata tgaatgagtc cgagcttgtg tacaagaaat gccgcaattt caatgctgtt 306181 tttcccgagg tgcggacggg cgccatgagc ctcttccccg atgatcgttc cctcaatgtg 306241 ctggcttgat ccgtgcagaa tagaaggagc gcagcggccg ttctgtgttt cctggatcgg 306301 acggacgtga acgccataca aatagtcgat atcatcaagc acgccttctt ctatcatttt 306361 caaggcgccg ccgccttttt cttctgccgg ctgaaagata aaacggattg tgcccttcgg 306421 aagctcaggt tgttttttta gcagcattaa cgtgcccaat gccattgtca tatgtgaatc 306481 gtgtccgcag gaatggttgg cgcgaaatgt gccgttaacc tcctgccaca gcgcgtcaat 306541 atcagcgcgt accgctacaa caggtgagcc tgagccgatt tcgccgacaa ccccggtgca 306601 gtctgaaaac gtgcgcgtcc ggcaccctaa atcctcaagc ttttgtttca aaaatgaagt 306661 tgtctcatat tccttccagc tgacttcagg gttcgcgtgc agatgctcga agatgtccat 306721 aatggtttgt ttcatttctt ctgaaagctt ttgcatggta agaaatacct ccttctatca 306781 gaatgaattt ttaccttctt tactttattt atattgaaac aggaagatag gctgtatata 306841 atatagcaca tattgctact attcagaata attaatattt tcaaacagag gggatggatc 306901 gaaatatgag tatgccagca gccgaaacac agcctaagaa aaaacgtatg acatttaaaa 306961 tgcctgacgc ctatgtcctc ttatttatga ttgctttcat ttgcgcaatc gcttcatata 307021 ttgtgccggc aggtgaattt gaccgcgtga caaaggggga tgtcacgacc gctgttccgg 307081 gaagctatca ttcaattgaa cagtctccgg tcagattgat cagctttttt acttctctac 307141 aggatggaat ggttggatca gcacccatca tctttctgat tttattcaca ggcggcacca 307201 ttgctattct agaaaaaacg ggtgccatca atggcctgat ttacaatgtc atcagcaaat 307261 tccgcacaaa gcaattatta tttatttgta ttgtcggcgc attgttctcc attctcggaa 307321 caaccgggat tgtcgtgaat tcagttatcg gttttatccc catcggcctc attgtggcac 307381 gatccttaaa atgggacgca gtcgcgggag ccgctgttat atacatcggc tgctacgctg 307441 gatttaactc caccatatta tcaccgtcac cgctcggttt atcacaatca atcgcggagc 307501 tccctctttt ctcaggaatc ggcctgcgag ttgtgatata catatgcttt ttgctgtctt 307561 ctattattta tatctatttg tatacgagaa aattaaaaaa atcaaaagat gccagtgtgt 307621 taggaacaga ttggttccct gcggcaggaa tgggcgaagc cggtaaagaa gaagatcagt 307681 cagtgccgtt taccgttcgc cataagctga ttttggctgt ggcgggactc tcacttgtcg 307741 gatttttata cggcgctttg aagcttggct ggtcagattc ccaaatggct gcgacattta 307801 tttttatttc tgtccttgcc ggtttaatag gcgggcttgc ggcgaacgat attgccaaaa 307861 ccttcattac gggctgccaa agtcttgtat acggggcgct gattgtcggg atggcacgaa 307921 gcatttccgt tatccttgaa aatggaaagc ttctcgatac tgtcgtcaat gctttggctt 307981 cacttttgga tggattcagc ccgattgctg gggcaatcgg catgtatatc gccagtgcgc 308041 tgcttcattt tctcatctct tcaggttctg gcgaagccgt tgtatttatt ccaatcctgg 308101 cgccgctcgc tgatttgatg ggaatcacga gacaggttgc ggttgaagcg gttatgcttg 308161 gagaaggggt cgtcaactgt gtgaacccga catccggcgt tctcatggcg gtgcttgccg 308221 ccagcggtat tccgtatgtc aagtggctgc ggtttatggt gccgcttgct ctgatttggt 308281 tcttgatcgg gcttgtcttt atcgtgatcg gagtcatgat caattggggg ccgttttaac 308341 gattgctgcc cgccggcttg tacggcgggc ttttgagtta ttcattgcag aagcgcaggc 308401 tgttattgta acatgtaagc cataagccat tcgtaaaagt gcgggaggaa ggtcatgaat 308461 aatctgcgta atagactttc aggcgtgaat gggaaaaata agagagtaaa agaaaaagaa 308521 caaaaaatct ggtcggagat tgggatgata gcgggagcat ttgcgctgct tgatgtgatc 308581 atccgcggca ttatgtttga atttccgttt aaagaatggg ctgcaagcct tgtgtttttg 308641 ttcatcatta tcttatatta ctgcatcagg gctgcggcat ccggaatgct catgccgaga 308701 atagacacca aagaagaact gcaaaaacgg gtgaagcagc agcgaataga atcaattgcg 308761 gtcgcctttg cggtagtggt gcttacgatg tacgacaggg ggattcccca tacattcttc 308821 gcttggctga aaatgattct tctttttatc gtctgcggcg gcgttctgtt tctgcttcgg 308881 tatgtgattg tgaagctggc ttacagaaga gcggtaaaag aagaaataaa aaagaaatca 308941 tcttttttgt ttggaaagcg agggaagcgt tcacagtttc gggcagcttt ttttatagga 309001 acattgattt gtattcactc tgccaagttg ttttgataga gtgattgtga taattttaaa 309061 tgtaagcgtt aacaaaattc tccagtcttc acatcggttt gaaaggagga agcggaagaa 309121 tgaagtaaga gggatttttg actccgaagt aagtcttcaa aaaatcaaat aaggagtgtc 309181 aagaatgttt gcaaaacgat tcaaaacctc tttactgccg ttattcgctg gatttttatt 309241 gctgtttcat ttggttctgg caggaccggc ggctgcgagt gctgaaacgg cgaacaaatc 309301 gaatgagctt acagcaccgt cgatcaaaag cggaaccatt cttcatgcat ggaattggtc 309361 gttcaatacg ttaaaacaca atatgaagga tattcatgat gcaggatata cagccattca 309421 gacatctccg attaaccaag taaaggaagg gaatcaagga gataaaagca tgtcgaactg 309481 gtactggctg tatcagccga catcgtatca aattggcaac cgttacttag gtactgaaca 309541 agaatttaaa gaaatgtgtg cagccgctga agaatatggc ataaaggtca ttgttgacgc 309601 ggtcatcaat cataccacca gtgattatgc cgcgatttcc aatgaggtta agagtattcc 309661 aaactggaca catggaaaca cacaaattaa aaactggtct gatcgatggg atgtcacgca 309721 gaattcattg ctcgggctgt atgactggaa tacacaaaat acacaagtac agtcctatct 309781 gaaacggttc ttagacaggg cattgaatga cggggcagac ggttttcgat ttgatgccgc 309841 caaacatata gagcttccag atgatggcag ttacggcagt caattttggc cgaatatcac 309901 aaatacatct gcagagttcc aatacggaga aatcctgcag gatagtgcct ccagagatgc 309961 tgcatatgcg aattatatgg atgtgacagc gtctaactat gggcattcca taaggtccgc 310021 tttaaagaat cgtaatctgg gcgtgtcgaa tatctcccac tatgcatctg atgtgtctgc 310081 ggacaagcta gtgacatggg tagagtcgca tgatacgtat gccaatgatg atgaagagtc 310141 gacatggatg agcgatgatg atatccgttt aggctgggcg gtgatagctt ctcgttcagg 310201 cagtacgcct cttttctttt ccagacctga gggaggcgga aatggtgtga ggttcccggg 310261 gaaaagccaa ataggcgatc gcgggagtgc tttatttgaa gatcaggcta tcactgcggt 310321 caatagattt cacaatgtga tggctggaca gcctgaggaa ctctcgaacc cgaatggaaa 310381 caaccagata tttatgaatc agcgcggctc acatggcgtt gtgctggcaa atgcaggttc 310441 atcctctgtc tctatcaata cggcaacaaa attgcctgat ggcaggtatg acaataaagc 310501 tggagcgggt tcatttcaag tgaacgatgg taaactgaca ggcacgatca atgccaggtc 310561 tgtagctgtg ctttatcctg atgatattgc aaaagcgcct catgttttcc ttgagaatta 310621 caaaacaggt gtaacacatt ctttcaatga tcaactgacg attaccttgc gtgcagatgc 310681 gaatacaaca aaagccgttt atcaaatcaa taatggacca gagacggcgt ttaaggatgg 310741 agatcaattc acaatcggaa aaggagatcc atttggcaaa acatacacca tcatgttaaa 310801 aggaacgaac agtgatggtg taacgaggac cgagaaatac agttttgtta aaagagatcc 310861 agcgtcggcc aaaaccatcg gctatcaaaa tccgaatcat tggagccagg taaatgctta 310921 tatctataaa catgatggga gccgagtaat tgaattgacc ggatcttggc ctggaaaacc 310981 aatgactaaa aatgcagacg gaatttacac gctgacgctg cctgcggaca cggatacaac 311041 caacgcaaaa gtgattttta ataatggcag cgcccaagtg cccggtcaga atcagcctgg 311101 ctttgattac gtgctaaatg gtttatataa tgactcgggc ttaagcggtt ctcttcccca 311161 ttgagggcaa ggctagacgg gacttaccga aagaaaccat caatgatggt ttcttttttg 311221 ttcataaatc agacaaaact tttctcttgc aaaagtttgt gaagtgttgc acaatataaa 311281 tgtgaaatac ttcacaaaca aaaagacatc aaagagaaac ataccctgga aggatgatta 311341 atgatgaaca aacatgtaaa taaagtagct ttaatcggag cgggttttgt tggaagcagt 311401 tatgcatttg cgttaattaa ccaaggaatc acagatgagc ttgtggtcat tgatgtaaat 311461 aaagaaaaag caatgggcga tgtgatggat ttaaaccacg gaaaggcgtt tgcgccacaa 311521 ccggtcaaaa catcttacgg aacatatgaa gactgcaagg atgctgatat tgtctgcatt 311581 tgcgccggag caaaccaaaa acctggtgag acacgccttg aattagtaga aaagaacttg 311641 aagattttca aaggcatcgt tagtgaagtc atggcgagcg gatttgacgg cattttctta 311701 gtcgcgacaa atccggttga tatcctgact tacgcaacat ggaaattcag cggcctgcca 311761 aaagagcggg tgattggaag cggcacaaca cttgattctg cgagattccg tttcatgctg 311821 agcgaatact ttggcgcagc gcctcaaaac gtacacgcgc atattatcgg agagcacggc 311881 gacacagagc ttcctgtttg gagccacgcg aatgtcggcg gtgtgccggt cagtgaactc 311941 gttgagaaaa acgatgcgta caaacaagag gagctggacc aaattgtaga tgatgtgaaa 312001 aacgcagctt accatatcat tgagaaaaaa ggcgcgactt attatggggt tgcgatgagt 312061 cttgctcgca ttacaaaagc cattcttcat aatgaaaaca gcatattaac tgtcagcaca 312121 tatttggacg ggcaatacgg tgcagatgac gtgtacatcg gtgtgccggc tgtcgtgaat 312181 cgcggaggga tcgcaggtat cactgagctg aacttaaatg agaaagaaaa agaacagttc 312241 cttcacagcg ccggcgtcct taaaaacatt ttaaaacctc attttgcaga acaaaaagtc 312301 aactaaccgc aactttagag taaagggctg attgtcaatg tgggagcagt tgtatgatcc 312361 gtttggaaac gagtatgtga gcgcacttgt ggcgctcact ccgattctct tttttctttt 312421 ggctttaact gttttgaaaa tgaaaggcat tcttgcggca tttcttaccc tagccgtcag 312481 tttcttcgtc tccgtttggg catttcatat gccggttgaa aaagcgattt cttctgtttt 312541 gttaggaatc gggagcgggc tgtggcccat tggctacatc gtcctgatgg cggtgtggct 312601 gtataaaatc gccgtgaaaa ccgggaaatt taccattatt cggtccagca ttgccggcat 312661 ttcgcctgac caacgattac agctattatt aattggtttt tgttttaacg cgtttttaga 312721 aggcgcggcc ggttttggtg ttccgattgc gattagtgcg gcgctgctcg tcgaacttgg 312781 ttttaaaccg ttaaaagcgg cggcgctctg cttgattgca aacgctgcct ccggagcctt 312841 tggggcgatt gggattcctg tcatcacagg ggcgcagatt ggtgatttgt ctgctcttga 312901 gctgtctcgg acattaatgt ggacactgcc gatgatctca tttttaatac cattcctgct 312961 tgtattctta ttagaccgaa tgaaaggaat caaacagaca tggcccgctc ttctggttgt 313021 gagcggtggg tatacagcgg ttcagacact gacaatggcg gtgctcgggc cggaattagc 313081 aaacattttg gcggccttat tcagcatggg cgggcttgcc ctcttcctcc gcaaatggca 313141 gccgaaagag atttaccgcg aggaaggggc cggcgatgct ggtgagaaaa aggcataccg 313201 tgccgctgac attgcgaaag cgtggtctcc tttctacatt ttaactgcgg cgatcaccat 313261 ctggagcctt cctgccttca aagcgctttt ccaagaaggc gggctgttat atcaatcaac 313321 gctcctgttc aaaatgcctt ttctgcatca gcaaattatg aaaatgccgc cgattgcgcc 313381 atctgccatg ccgttagatg cagtctttaa agttgatctg ctgtcagcga ctggtacagc 313441 gattttagcg gcggtcatcg tgacagggct gttcagcaaa aagttctcct ctcgggatgc 313501 ctttgcttcc ttgaaggaga cgggaaaaga gctgtgggtg ccgattatga cgatctgctt 313561 cgtgatgggg tttgccaatc tggccaactt cgcagggctc agctcttcaa ttgggttagc 313621 attggcgaaa acaggagacc tgttcccgtt tgtcagtcct gttctcggct ggattggcgt 313681 gttcatcacc ggttctgttg tcagcaataa tgctttgttc ggccatttgc aggttgtcac 313741 gggagcgcag atcggtgcgg gttcagattt gctgttagcc gcaaatacgg cgggcggtgt 313801 catggcgaaa cttgtttctc ctcaatctat cgccatcgct gccgcagcgg tcggccaaac 313861 aggcaaggaa tctaaactgt ttaaaaggac agtggcgtac agcctgattc tgttattgat 313921 catttgtata tggacgttta ttcttgcaag attaggagtg taatagaaaa aagcagtaca 313981 tgcccagcat gtactgcttt ttttatgtta atttgctttc tttgtcattt cggctgttgt 314041 tttcactctg gcttttccca taaataaaat ggtaaccgcc gcgaggacaa ttggaatcaa 314101 agcgagcaaa aagacatacg tgatacttga tgacatcgcg tcaataatgc gattcaggat 314161 cgcatcagga atctgggaac gtgttcccgc ttggaatatc tcctgcgggt cgccaatatt 314221 ttgcgcagcg cctgatcccg ctgagccttt cataccgctg aaggcgtcat tcagcttgtt 314281 tgtgaatacg tttgtttgca ccgttccgaa aatggtgaca cctaaggtca tgccaaatga 314341 tcgcaaaaat gaatttgtag agtttgccgt tccccgaaag cgaggttcaa gatcattcat 314401 cgatgccgcc ggcagcaggg agaagttaaa gcctacacca aagcctgaaa tcatcataaa 314461 gactgtcagc catacccgtg ctgtgtcagg cgtcatattg gaaagaagca gcatgccgat 314521 aaagaaagct ataacagata tcagcatcaa attgcggaag cttgccttcg tttggaagat 314581 cccgccgatc atgcttccga tgactgatcc aatcatcatc ggcgtcagaa tgaagcccgc 314641 gcttgtcgcc gagctgccgt agaccgcctg aacgaaaatc ggaataaata ccgctaaaat 314701 aataaatgtt ccgccataca ggaaagcgag aatctgtgct gtggcaaaca agcggttctt 314761 aaacatccag aaagaaataa tcggctcttc tgcttttctc tccacaataa aaaaggcaat 314821 gaagaaaacg gcgaatacaa taaacagccc gatgatctga atggagttcc aatcgtatgt 314881 tttgccgcca agctcaaggg cgaacatcag gcatacaatg gatacgacta aggtaatcgc 314941 gccgccccag tctattttct gctttctgtg ctccagagat tctttgtagt agcgaataat 315001 gaaaaacaat gacaatgcgc cgatcggcac attgatgtaa aacacccagt gccagctgat 315061 cgaatctgta atgatcgcgc ctaagagcgg accaagaaca ctggataatc caaatacagc 315121 accgaacatg ccggacattt ttccgcgttt ttccggcgga aacaaatcaa agataatggt 315181 aaaggcaatc ggcaggagcg cgccgcctcc gatcccttga atggcccgga agatgatcag 315241 ctgattcatc gtctgggcaa tcccgcataa agcagaaccg attaagaaaa aaataagtcc 315301 aaacaggaaa aaacgttttc ggccgtacat atcggaaagc ttgccgtaaa tcggcatgcc 315361 agccataacc gccaccatat aggatgccgt cacccaggca aatttatcga agcttccaag 315421 atcggctacg atattgccca tcgcggtggc aacaatcgta ttgtccattg cagacatcaa 315481 gatgcccagc aggagaccga ggaccacaaa tttggtggaa gcctgttttg ctgttgttgt 315541 gtccatttgt tctacctcct cttacttttc tatgtaagtt ctgatatcat gataatagtt 315601 tgattgttga atatctcgat tatcaagata aactcgattt tatagggagg actgtcagtt 315661 gtcaacaaga aattccagaa gtgagttgga aaagactgct gttcagcttt ttcgaaaact 315721 gggcacaaga acggttctgt ttcatcaggc agccgctcaa gctctcggtc tgtttcccac 315781 cgatttgaaa tcagctgaca ttttaaatga agcagggccg atgacggccg gagagctggg 315841 gaaaaaaacc ggcctcagca cgggttccgt cacggcgctt gttgaccggc tggaaaaagc 315901 ggggtatgtg gctcgtgaaa aggacccgaa cgatcgcagg agagtcgtaa tcgtcccttt 315961 gactgcttcg aaaaaacata taaaggattt gttccgtcct ctgtctgagt caacgatgga 316021 tttgtgccgc gaatatacgg aagaggagct ggaactcatt ttcagttttg taggcaaagc 316081 tgccgatatt atggaggaag agcttgaacg tctgaaacag taagtgaatt tgtgcatagc 316141 ttggcccgtt cccgaataaa ttgtacaagt tacataagag aagggagtac gggccggtga 316201 acattttttt gagctatatt gtgctgggac tgtccttgtc tgcgcctgtg gggccagtga 316261 atgcggcgca aatagacaaa ggaattaaaa acggtttttg gcatgcatgg attttcggtt 316321 taggcgccat gacagcggat gggctgtaca tgctttttat ctatttcggg ctgtcgcagt 316381 tcttgaccgc tccatttgtg aaaacgtttt tgtggctgtt cggctttttt gtcctgacct 316441 ataccggaat tgaaacgctg aaaaacgtca gagaaccgat ggatgtgcga agctcgcggg 316501 ggaaaccgtc atacaggaaa acattcgcat cgggttttct catttcattg tcaaacccat 316561 tgagcatcct tttttggctt ggaatttacg gaagcattct tgcgaaaaca gcagaggcct 316621 acaatatgaa tcagcttcta atctatagct ccggcatcat gatcggcatt ttaatctggg 316681 atttctgcat ggctatcaca gccagtacgt tcagaaacct gcttcatgaa aagctattga 316741 gaggattgac cggaatcgcc ggtgtatccc tccttgtgtt tggcttttac tttggttatc 316801 agggcatcaa acagttattg ggctgattca tgaaggacag tcacctgccg cttccagttt 316861 taatatagta tccagatgat actggaggtg gatcaatggt gaatgggatt tacaccaaaa 316921 gttttctgga acgtattcag gaagagcttc ctgaatggca aagaatcgct tttgagctgc 316981 tggcagaaac tctgggggac gacgcggata catttccgtg cattcccgga cgccaggcgt 317041 ttctgactga tcagcttcgg attgcttttg ccggagatcc gcgggaaaac cgcacagcgg 317101 aggaactggc tccgttgctt gcggagtacg gcaagatatc gcgggacacg ggaaaatacg 317161 catccctcgt tgtgttgttt gatacaccgg aagatttggc ggagcattat tcgattgaag 317221 cgtatgaaga gctgttttgg cgctttttaa atagactgag tcatcaagac gaaaaagaat 317281 ggccggaaga cattccggcc gatcctgagc attataaatg ggagttttgt tttgacggcg 317341 agccgtattt cattctgtgc gctacaccgg ggcacgaggc aagaagaagc cggagctttc 317401 ctttttttat ggtcacgttt cagccaaggt gggtgtttga tgacctaaat ggatcaactg 317461 catttggccg taacatgagc aggctgatcc gatctcgttt agaggcctat gatcaggctc 317521 cgattcaccc gcaattaggc tggtacggag gaaaagataa tcgtgaatgg aagcagtatt 317581 tcctccgtga tgacgaaaaa caggtatcga agtgcccgtt ttcttattta aagaacatgt 317641 tcaacaaaat gaaataaatc aaggactggc agggcgatct ttatgaccct gctttttttg 317701 atagatcatg gtaacgatgg cgataatcac gagaaaacct atgctgacga aaaaaccggg 317761 ccggcttgat ttttcaaaca atgtaccgga cacagctgca gcaatcagaa ccatcgctaa 317821 ataaatttgc gtttttccca tgccctcggg atcagtcagc tttttgctgg agaacaggat 317881 aaacagccaa gtgtataaaa gcataagccc cgcagctgtt gtcatatgct cataaatgtt 317941 tttaggcagc actaacgaca aaataatgga gaggacaagc cccgcaaacg tcagcccaag 318001 tgccggccag catatttttt tgccttcctt tagagtaaag catttcggcg cgtcgccgtc 318061 atcagccatt gtacaaagca atgtcgtaac cgcaaatagc gaagcgacaa gggtcgagaa 318121 ccctgcgatg atgaaaatcc cgttaaatat atcaaggatg atctcaaggt tatatccttt 318181 taatgacgta atgaacggac tgtcctgttc agtaaacgtg tgtaacggaa ccaaaagcag 318241 agcaagcccg attgaaatga tataaataat cgccagcgtc gccagcatca gtttccctga 318301 tttagacgct tcctcaggtt tttttaagtg aaccgccatc agccccatga cctcaattcc 318361 gccaaaagcg taaaacgcgt agattaaacc tgtccacagc cccatggcgc cgtatgggaa 318421 aaactcactc gtcttatttg gaacatgtat gccatgattt ccgccggaca ggataccgca 318481 taaagccagg atggcaatga caataaacat aaaaatagca gctgttttaa tgactgccag 318541 cacgttttct gttttttcaa agacggacag gccggtgaaa ataataagga gcccaagtac 318601 tgcgtagatt gaggcaaaca cccatagcgg cacttgagga aaccaatgct tcgtaaagag 318661 cgaaatggct gtcagctggc ttccggtaat cagcatttct gatgtccagt acacccagcc 318721 gttgctgaag cctgcccatt tgccgaatgc ttttcgggca tacgcacaaa acgagccctt 318781 ttccggctgc ttcgccgata gcttggcgag ctgttcaaag acaaaatacg taccgatccc 318841 tgcgatcaga aatgaaagga gaacggaaaa accgcttttt acaattgcga tgctggaacc 318901 gagaaagaag cctgttccaa tcgtgcagcc gactccgatc agtgacagct gccaccaagc 318961 cagattccct tttggctggt ctttttttgt ttggctcatt atttattcaa ccccttttat 319021 ctaaggttag attgtgatct gtccaaagct tatatacatc ggatttttgc ctctttttac 319081 atggagaagg aagcagacgc tcatactaat gaaaaaagga gcaaaccaat gacacagcaa 319141 tatattgtgg agccgaaaaa agggcttggg ctgaagctga aaaaggggca gattttaaag 319201 gtggttgatg tagaagggca gcaggtggct gattttgtcg cataccatgc caaggatttt 319261 tatgaacacc ttgatcaggg agcgacgata gacgccaatc actccattca tgtgaaggtc 319321 aacgaccatc tctactccaa cctgtataag ccgatgttaa ccctgattga agatacggtc 319381 ggcaagcatg atctgctgtt gcccgcctgc cgtcctgata tgaacaggct cttatatggg 319441 aagcaaaagg atgagtttca ggatacgtgc tatgacaata tgaaccgtgc gcttgagcag 319501 tttggcgtac cgaagcccca catgcattac ccatttgcga tttttatgaa tactgtcctt 319561 gatgagaaag ggaatctgtc tgtggaaacg ccgctttcga atgccggaga ttatgtaagg 319621 ctcagggcgg agatggattt aattgtcgcg ttttcttcct gcccgattga aaaagggaaa 319681 tgcaatggcg acagtgtgac atccatacgg gttgaagtca gctgatctct cttgttcaca 319741 gtgaatgaag acctgtgcta tatttaatag ggatacataa cagtcatgat tcattttcat 319801 tgatttaggg aaatgatcag taataaggga aaatgtacag gaggaatgat tgggatgagc 319861 atgcaggaaa agattatgcg tgagttacat gtgaagccct caattgatcc aaagcaagaa 319921 attgaggacc gagtcaattt tttaaaacaa tatgtaaaga aaaccggtgc taaaggcttt 319981 gtattgggaa tcagcggggg ccaggattca acacttgcgg gaagactcgc tcagcttgcg 320041 gtggagagca ttcgcgagga gggcggagac gctcaattta tcgcggtccg tcttccgcat 320101 ggcacacagc aggatgaaga cgatgcccag cttgctttga agtttattaa gccggataaa 320161 tcatggaagt ttgatattaa atcgacagtc agcgcttttt ctgatcagta tcagcaggaa 320221 acaggcgatc agctgacgga ctttaataaa ggaaacgtaa aagcaagaac aagaatgatc 320281 gcgcaatacg cgatcggcgg ccaggaaggt cttcttgtgt taggaacaga ccatgctgct 320341 gaagcagtga ctggtttctt tacgaagtac ggtgacggcg gagcagacct cctgccgctg 320401 acaggcttga cgaagcgcca gggaagaacc ttgctgaaag agctgggtgc accggaacgc 320461 ttatacttaa aagaaccgac tgccgatctg ctcgacgaaa aaccgcagca gtcggatgaa 320521 acagagcttg gcatttccta cgacgagatt gacgattatc tcgaaggaaa agaagtatca 320581 gcgaaagtat cagaagcgct ggaaaaacgc tacagcatga ctgaacataa acgccaggtt 320641 ccggcgtcta tgtttgatga ctggtggaaa taagttgaag aaagcccgct ctcggagcgg 320701 gcttttgtcg tgtacagaag ctttatttga tgcggatatg attcagcttt accattaatc 320761 tgtcggcgaa ccttcggagg ctgcctcttg tatcaggatc taatgggagt tcggctctcg 320821 cggcaatgtt ctctgccaca tcctgaatcg acaggttgtc tgtttgaatg tggtcctcaa 320881 aaatgggtga tgataatcct tcaacacagc ggtcaatttg tttggcggcc catgagtttt 320941 ttccttctgc tctggtgcgc agccttttta acaaggtttc ctttgaagcc attagtgtaa 321001 agtggtgaac gatcctgcct tcctgtctga gcctgccgat gatctcattg aagtattcag 321061 ggtgtacaat cgtcataggc acaataagga tgccgcggta tgtatctgtc agagaagcta 321121 gcaaactgta attgaacgcc cgccataaag gatagctttg aaaatcgtcc tttgcgatct 321181 cctgcggcac catggagcgc agcgcaaaac ccattttctc gggatcatac acgtaagatg 321241 ggttcagcct tctgtgcagt tcgaaggctg tttgtgtttt tcccgaaccg aatgccccgt 321301 ttatccaaat gatcatcgcc atttctccct tcctatttat catacagaaa aagacccttc 321361 catcgaagag tcagctggaa aaacaataaa ggcggaaggt tttaacgctt ttttgcgtcg 321421 aagtattaaa atacctgcag aaatgttgta caatgaatgt cattcaggca aaaatggcta 321481 caacaaagcg cactataagc ttgaccggta aagccggtat ctatataaat attcgctaaa 321541 taagcatata atgaatatat aatttcattc cttaggagga tttcgccgaa gatgaacgct 321601 aaacgagcca tcccagtaag agaaagaaat atcgtcctga tcggattcat gggtgtagga 321661 aaaacaacaa tcggccaatt ggtcgctaaa aaattatata gagattttat tgatattgac 321721 cagcagatcg aaaaggattt caatatgtca attcctgaga tatttgagaa aaagggagaa 321781 gactttttcc ggaaaacgga gaaggaatat attttagaca tctgccatca taaacgattc 321841 aaaatcgtat ctctgggcgg gggatctttt aaacaagaag aaatcagaaa ttgctgtctg 321901 gaaaactgtc tcgtgcttca tctggacctg tcatgggaga actggaagca gcgcgcggat 321961 ttattgatcg aaagccgccc tgtactgcat aaccgttcaa tggatgaaat ggaacagctg 322021 tttaacgaaa gaaaagtcat ttatgacaag cacaattcaa aagtggcaac agacaacctt 322081 tccccggaag aggttgccga ttacattgtt gagacattaa aaattggctg ggatctttat 322141 cagccgatgt aaaaagccgt gcgcagcgca cggctttttt tatcgtttta tcccttgtat 322201 caaaatcgct tttaaacaaa aggagatggg ctgtccgttt tggttcaatg taatacagaa 322261 cgtgtcgcgt gcttcgtctg atgcgtgatt caagtgggta atgatttgtt tttctcggtc 322321 agcgggggtt ccgcctcgtt tgatccagct atcgtattga atcggcaagt tccacttttg 322381 gatgtcttga taggccagtt gattggcgct gaacatcgcc tgccattctg ataatgagct 322441 ttcacgaaca tgggaagggt ctcgaagccg gttcaaatga ttgacaaact catcaagaac 322501 gggatcttca ggcgcgtaat gatcaactaa gagaaaacgt ccgtcctgtt ttagtacgcg 322561 tgcaacctct ctgacagctt tgcggacatc tgaaaaatgg tgggctgcgt atcggcaggt 322621 gatgatgtca aatgaatcgt cggggaaggg gagtgactct gccgttcctt gctgaaagcg 322681 tacgttttca actccttttt cttgcgcgaa ggaggacgca acctcaacca tctctttcgt 322741 tgcatcaaca ccgatgcact cctgtacata aggagaaaat gccagcgccg tatggccggc 322801 gcccgctcct atatccagca ctcgatgctc tgcccggcat tccgctgttt tgatcatcaa 322861 ccccaaatct tccccctcgg caaatacctt ttcatcccga tacatctcgg cgtttttaga 322921 aaacggtgtt tcatttgtca tttgaaccag ctccttcttt tcgtaaatga tgatatggat 322981 tatgttagca atttctgtta tgattcgtcc aagatataaa aatgatgaaa atgataggtt 323041 caacctatgg aggctgaaat ggatattaaa gtgatggaat atgcagcgga aattgcccgg 323101 cgccaaagct ttacaaaggc ggcggaacat cttcatatcg cacagccgtc tctcagccag 323161 caaatcaaaa agcttgaggc tgagctgggg cttacccttt ttcacagatc ccatggctct 323221 gttacactga cacctcacgg caggcgtttc attgaaaaag ccgaggacat cattcgttcc 323281 agagatgatt tgcttcggga aatgcaggag cgatcacagg gaatcggtca taaattatcc 323341 atcgggattc ctgctgtaac agggagatat ctctttcctc cgctgctgaa gcagtttttg 323401 gcgcgctatc ctcatgtgga ggttcagctt gttgaaaaag atccggtttc attagagaag 323461 atgacggcaa agggagaagt tgacctttct gttttatcct tgcccatcga ggatgaacgg 323521 ctctccatta cacccttgct cacggaaccg gttgttctcg cggtgccgaa ggaaaaacaa 323581 aggtggatgc cgccggaatt ggtcgcgctg attgagaaag cgctggaaga agatgaggga 323641 cgccagccgt gtgtgccgat tgacatggta aggaacgtgc cctttattct gttaaaagaa 323701 ggcttcggct ttcgcaggac agttctcgat ctctgtgcgg aaagcggctt taagccgaat 323761 gctgccttta agacgagcca tattgaaacc gcccaatctc ttgtggctaa cggattaggt 323821 gtgacaatgg caccgaatat ggtcagaagg gataaagatc cgggtgtgat ctatttatcg 323881 attcaatccg cgccatcacg aaccctcgtc tttgtctttt taaagaaccg ctatgtcagt 323941 ctgacggccc aggcctttat ggaactaagc cgggaaagtc ttaaacaaac gtttgatgaa 324001 ggctgtctgg gaaacaaaga tgaaaatatt tagaaaacaa agacgaaacg tggtagtata 324061 ggaatacaaa ctaaatctta taaaacaaag gggaataatc ggaaatgcaa ctattcgatc 324121 tgccgctcga ccaattgcaa acatataagc ctgaaaaaac agcaccgaaa gatttttctg 324181 agttttggaa attgtctttg gaggaacttg caaaagtcca agcagaacct gatttacagc 324241 cggttgacta tcctgctgac ggagtaaaag tgtaccgtct cacatataaa agcttcggaa 324301 acgcccgcat taccggatgg tacgcggtgc ctgacaagga aggcccgcat ccggcgatcg 324361 tgaaatatca tggctacaat gcaagctatg atggtgagat tcatgaaatg gtaaactggg 324421 cactccatgg ctacgccaca ttcggcatgc ttgtccgcgg ccagcagagc agcgaggata 324481 cgagtatttc accgcacggt cacgctttgg gctggatgac gaaaggaatt cttgataaag 324541 atacatacta ttaccgcggt gtttatttgg acgccgtccg cgcgcttgag gtcatcagca 324601 gcttcgacga ggttgacgaa acaaggatcg gtgtgacagg aggaagccaa ggcggaggtt 324661 taaccattgc cgcagcagcg ctgtcagaca ttccaaaagc cgcggttgcc gattatcctt 324721 atttaagcaa cttcgaacgg gccattgatg tggcgcttga acagccgtac cttgaaatca 324781 attccttctt cagaagaaat ggcagcccgg aaacagaagt gcaggcgatg aagacacttt 324841 catatttcga tattatgaat ctcgctgacc gagtgaaggt gcctgtcctg atgtcaatcg 324901 gcctgattga caaggtcacg ccgccgtcca ccgtgtttgc cgcctacaat catttggaaa 324961 caaagaaaga gctgaaggtg taccgctact tcggacatga gtatatccct gcttttcaaa 325021 ctgaaaaact tgctttcttt aagcagcatc ttaaaggctg ataaatgtga aaagccgccg 325081 catatcatca ggcggttttt ttctgcaaac tgccggaatg agaacagact ggagacgaat 325141 agatatgaaa caaagaatca ttgatgaatt aaaacggatc gagcagtcat acggagtcaa 325201 aatcgtgtat gccgtcgagt caggaagccg cgcatgggga tttccctcgc aggatagtga 325261 ttacgacgtc cgctttattt atgttccgaa aaaggagtgg tacttttcaa ttgagcagga 325321 gcgtgatgtc attgaggaac cgattcacga tttgctggat atcagcggct gggagctgag 325381 aaaaacgctt cggcttttca aaaagtcaaa ccctccgcta ctcgaatggc tgtcctcaga 325441 cattgtgtat tatgaagcat ttacgaccgc agagcagtta agaaaactcc gcacggaggc 325501 atttaagcct gaagcaagcg tgtatcacta tatcaatatg gcgagaagga acgtcaagga 325561 ttatctacaa ggacaagagg tcaaaattaa aaagtacttc tacgttcttc ggcctatttt 325621 ggcctgccaa tggattgaaa agcacggaac cataccgcca atggacttta ctgttttgat 325681 gaatgaactt gttgctgaac ccgagctgaa ggctgaaatg gaaaccttgc ttgaacggaa 325741 aagaagaggg gaagagcttg acctcgaagc aagaatcgat gttattcacc aattcattga 325801 aacggaaatc gaaagaatca tggaagcggc aaaagaactg aaggcagaga aaaaagatat 325861 gacatctgaa ttgaaccgtt tgcttttgaa tacggttgaa gaagtgtgga aggatggagg 325921 aagctgatgt tttttgtcgc ttccttttct cctttattcg acagaatccc cccccgactt 325981 tctaactatc tgattgtggc aaacccacaa aaataatcag aatctttgta ttttgagaat 326041 attgtgaacg ctggttttgt ccatttacaa taaactcata caaatacttc ttagattgcg 326101 gggtgttgag gttggaagtg atcacaagag attttttctt atttttatcc aaaagcggct 326161 ttctcaataa aatggcgagg aactggggaa gtcgggtagc agcgggtaaa attatcggcg 326221 ggaatgactt taacagttca atcccgacca ttcgacagct taacagccaa ggcttgtcag 326281 ttactgtcga tcatttaggc gagtttgtga acagcgccga ggtcgcacgg gagcgtacgg 326341 aagagtgcat tcaaaccatt gcgaccatcg cggatcagga gctgaactca cacgtttctt 326401 taaaaatgac gtctttaggt ttggatatag atatggattt ggtgtatgaa aatatgacaa 326461 aaatccttca gacggccgag aaacataaaa tcatggtcac cattgacatg gaggacgaag 326521 tcagatgcca gaaaacgctt gatattttca aagatttcag aaagaaatac gagcatgtga 326581 gcacagtgct gcaagcctat ctgtaccgga cggaaaaaga cattgacgat ttggattctt 326641 taaacccgtt ccttcgcctt gtaaaaggag cttataaaga atcagaaaaa gtagctttcc 326701 cggagaaaag cgatgtcgat gaaaattaca aaaaaatcat ccgaaagcag ctcttaaacg 326761 gtcactatac agcgattgcc acacatgacg acaaaatgat cgactttaca aagcagcttg 326821 ccaaggaaca tggcattgcc aatgacaagt ttgaatttca gatgctgtac ggcatgcggt 326881 cgcaaaccca gctcagcctc gtaaaagaag gttataacat gagagtctac ctgccatacg 326941 gcgaggattg gtacggctac tttatgagac gccttgcaga acgtccgtca aacattgcat 327001 ttgctttcaa aggaatgaca aagaagtaaa aaaggagaga ttatcatgac aacaccttac 327061 aaacacgagc cattcacaaa tttccaagat caaaacaacg tggaagcgtt taaaaaagcg 327121 cttgcgacag taagcgaata tttaggaaaa gactatccgc ttgtcattaa cggcgagaga 327181 gtggaaacgg aagcgaaaat cgtttcaatc aacccagctg ataaagaaga agtcgtcggc 327241 cgagtgtcaa aagcgtctca agagcacgct gagcaagcga ttcaagcggc tgcaaaagca 327301 tttgaagagt ggagatacac gtctcctgaa gagagagcgg ctgtcctgtt ccgcgctgct 327361 gccaaagtcc gcagaagaaa acatgaattc tcagctttgc ttgtgaaaga agcaggaaag 327421 ccttggaacg aggcggatgc cgatacggct gaagcgattg acttcatgga gtattatgca 327481 cgccaaatga tcgaactggc aaaaggcaaa ccggtcaaca gccgtgaagg cgagaaaaac 327541 caatatgtat acacgccgac tggagtgaca gtcgttatcc cgccttggaa cttcttgttt 327601 gcgatcatgg caggcacaac agtggcgccg atcgttactg gaaacacagt ggttctgaaa 327661 cctgcgagtg ctacacctgt tattgcagca aaatttgttg aggtgcttga agagtccgga 327721 ttgccaaaag gcgtagtcaa ctttgttccg ggaagcggag cggaagtagg cgactatctt 327781 gttgaccatc cgaaaacaag ccttatcaca tttacgggat caagagaagt tggtacgaga 327841 attttcgaac gcgcggcgaa ggttcagccg ggccagcagc atttaaagcg tgtcatcgct 327901 gaaatgggcg gtaaagatac ggttgttgtt gatgaggatg cggacattga attagcggct 327961 caatcgatct ttacttcagc attcggcttt gcgggacaaa aatgctctgc aggttcacgt 328021 gcagtagttc atgaaaaagt gtatgatcaa gtattagagc gtgtcattga aattacggaa 328081 tcaaaagtaa cagctaaacc tgacagtgca gatgtttata tgggacctgt cattgaccaa 328141 ggttcttatg ataaaattat gagctatatt gagatcggaa aacaggaagg gcgtttagta 328201 agcggcggta ctggtgatga ttcgaaagga tacttcatca aaccgacgat cttcgctgac 328261 cttgatccga aagcaagact catgcaggaa gaaattttcg gacctgtcgt tgcattttgt 328321 aaagtgtcag actttgatga agctttagaa gtggcaaaca atactgaata tggtttgaca 328381 ggcgcggtta tcacaaacaa ccgcaagcac atcgagcgtg cgaaacagga attccatgtc 328441 ggaaacctat acttcaaccg caactgtaca ggtgctatcg tcggctacca tccgtttggc 328501 ggcttcaaaa tgtcgggaac ggattcaaaa gcaggcgggc cggattactt ggctctgcat 328561 atgcaagcaa aaacaatcag tgaaatgttc taagcgggac taaatgggca tcctccctgc 328621 gggggtgtcc atttcatcca tatactataa aaaagaggag gaagtgccat agaaaacaca 328681 cagctgatta tttcgatttg tatttatatg gcgggaatgc tgctaatcgg ctactttgct 328741 tacaagcgta cgtcgaatct gacggattat atgctgggag gacgctcttt gggtccggca 328801 gtaaccgctc tcagtgccgg cgctgccgat atgagcggct ggctgctaat ggggcttccg 328861 ggcgccatgt tttctactgg tctgagcggc gcttggatcg tcatcggact ttgccttgga 328921 gcgtgggcga actggcttta cgtcgcacca cggctgagaa cctatactga aaaagcgggg 328981 aattctatta caattcccgg attcctggaa aatcgcttcg gagatcaaac aaagcttctc 329041 agactgtttt cgggaattgt cattttagtc tttttcacgt tttatgtatc gtccggaatg 329101 gtgtccggcg gcgtcttatt caacagcatc ttggggatgg attatcacac cggcctgtgg 329161 attgtgacgg gtgttgttgt ggcatatacc ctgtttggcg gctttttggc agtcagctgg 329221 acagattttg ttcaggggat tattatgttt gccgcactca ttcttgtgcc gatcgttacg 329281 tttttccaca cgggaggagc aggtgataca gttgctgaaa tccgctctgt agatcctgat 329341 atgtttaata ttttcaaagg aacgagcgtc cttggcatta tttctttgtt tgcctggggg 329401 ctgggatact ttggccagcc gcatattatt gtgcgtttta tggcgataac gtctgtcaaa 329461 gagatcaaaa gagcgcgcag aattgggatg ggctggatga ttttgtctgc agtaggcgca 329521 gtgctgaccg gtttgggcgg aatcgcttat taccatcagc gcggcatgac actgaaggac 329581 ccagagacga tttttattca attagggaat atcttgttcc atccgattat cacgggtttt 329641 ctgatttcag cgattttggc cgcgattatg agtacaattt cttcccagct gcttgtgaca 329701 tcaagctctc tggtagaaga tttgtataag tcgatgttca gacgctcagc ttcagataaa 329761 gaactggtgt ttttaggccg actggctgtt ctggctgttt caattgtcgc gttggttctg 329821 gcttgggaga aaaataacac catccttgga ttggtcagct acgcgtgggc gggcttcggt 329881 gcatcattcg ggccagttgt actgctcagt ctgttttgga aacgaatgac caaatggggg 329941 gcactcgccg gcatgattgt gggagcagcg actgtaatca tttgggcgaa tgccggtctt 330001 tcggactttc tgtatgaaat gatacctggt tttgctgcga gtctattatc tgtctttttt 330061 gtcagcatat tgacgcaggc tccgtcacaa gctgtcacag accagttcaa cgactaccaa 330121 gatacaatgt cgcaataaag atcgaaagga ggaggaaggg gctgtccctt tttcctcttt 330181 tctcctttta agcggccatt tttttctttt ggaaacaaac gtattttttt ctatacaaaa 330241 agaccccgta tggatatgat taaagtaaaa aaagtatagg agaaaaaggt atggaagagc 330301 ttttagagag agttttttca ttttcagatg ttgataagct aattgatttt attagctatg 330361 aactgcaaaa gccagtgata ctggaaagcg cggatttctt tttgttagcc tataattctt 330421 actatattaa ccattttgat tctgccaacc agcagactat tttttcgaaa aagtgtccgg 330481 tccagatttt tgagaggttt ctgaaggacg gaattattga aaaattgaaa acagagcctg 330541 agccttttcg cgtcaataaa attgaaagca ttgggttaaa ccagagggtg gtcgtgagtg 330601 caaagcacaa aggggaagtc atgggctaca tctggattca ggagctggac caaaatctga 330661 cggatgaaga gctcgacttt ttgtacgaga cctccttcca tgtcgggaaa atcatttata 330721 aaacgaataa attgaaacag gaaaaggaag aaaaagcaga ggatctcatc aaacgggcga 330781 tctatcagca atttacctct gagaaggaac tcagacggga agctgaaagg atcaacaccg 330841 tgctgccttc catgttttca gttgttatcc tgcacgccgc aaatggggat ggggaagcgg 330901 ttgaggattt aaaggaaaat atcaggtcgt acctgaattt acgggataag gtcagtcatg 330961 tcttaacgat cgaatcaaac attgtcatcg tcgtagcgag tttttcccaa aaaagctccg 331021 tctcctcagc agcttctgag tttattaaca agctgttaac acattttcac tttcaaaaaa 331081 tacctacccc tatttatatc ggtatcggaa acgaatataa tcacctatta aaacttggca 331141 agagctacac agaagcactt gaagtcatca aagccgcaga aatcaccggc aatcaggaaa 331201 acattccata tgaatatgcc aaactcggca tttaccgcta tttagaaagc atcgaacaga 331261 aaaatgaatt tttagaatac gagaataaag atttagcttt attaaaagca aaagacgaag 331321 aaagcagcac tgagctgctc aaaaccttgg aaatctatct cctcaacaac tgcaaaacaa 331381 aaccagcggc agaacagctg tttattcacc aaaatacatt gaattaccgc atcaaacaga 331441 ttactgagat gacgtcgatc gatttaagcg atttcagaac gcggtgccag ctctatctcg 331501 atttgatgct gatgaaaaag aaataaaaaa gaaaccagta cttgtactgg tttcgtcttc 331561 acttaaaatc ctctgtaaac atacggatca tcaggttttt taatggtatt ccagtcagtt 331621 actttgacga cagggagagt tgacttgaat ggctggtaat attctgaggc cagagtgccc 331681 ttaatgtgaa tccattcatc atccttgatg tccatgtcct tcggaaattc cacaagcatc 331741 ccgtacacgc cggaatcagc gatacagtga atgatgccaa accttaatac gaacagctga 331801 tttttgttaa ttgcgtttcc tttgtaagca aatccatgaa attctatcgt ccgtccgaga 331861 aattcacccg gatagttata gatggtttcc attcctttta ggaaatcgtc atcggtcaga 331921 gaaatctctt ttttgctgga atacttatta aacagctgtt tcatttgttt gtcatagctg 331981 tcttgcgcgt aataaaggct ggcatcaggc cgcaaatact gtgtttggga gtagtgatct 332041 ccgctctcca tcgccttaaa cgagaaccct tttgttttga ctatggatga gtcaagcgtt 332101 gcaatcggga agaagatgcc tgacaccaaa ggaaaaagaa aaacaacata aatcaaataa 332161 cgctgataaa atggcttgtt ttgttcatgg tcatgctcgt gatcatggcc gcacccgcaa 332221 tcatggtcat ggtgatgtcc gcttttttca ggcgacttga taaatagata tgcttggacg 332281 gcggtcagaa tggccagcag gaagatcgca ataaaggaaa gataggcata tttcatattg 332341 atatattttg ttagatttcc tgaggcatgc agatgataaa agaaaaacgt aaatcccatc 332401 agcaccaata aacgaaacat ccaatcaccc ctttaccagt agtgatcccg ctaaaacaat 332461 cacgacaatg tatgtaatca gcaggaaaac aaatcgtttt ttgaaggccg caagcatcat 332521 caatagattc ttaatatcca ccattgcacc aaagacgaga aaggcgatta acgatcctaa 332581 tgaaaacgtg ctgctgaagg aagacgcgat gaacgcatca acttctgaac aaagcgacag 332641 gacaaacgcc agacccatca tcacgaggga agaggataca tcattctgcc cgatcgcaag 332701 cagagtggat gttttgacat acgtctgcat agcggctgcg ataaaggcgc cgatgattaa 332761 atatttcccc acggagaaaa attcatcaat ggcatgccgc aaggtcccgc ccagtttttg 332821 gagcaaggtg ccgtgatgat gatggtggtg cccgggttca tcaggcttta aaagctggtt 332881 atccttaaat tgataggata agatgacccc gatgatcagc gaaacggcga gagccagtcc 332941 gcctctgtaa aagaccacgc tccatctatt cccgaacgca atataagtag aaaataaaac 333001 gataggatta atgataggcg cggtcagcat gaaagcaacg cccgcatgca gaggaactcc 333061 ctttaacaga agccgcctcg taatcgggat gatgccgcat tcgcaggcgg gaaataaaac 333121 gccggccagc gcaccgaata aaacggcgag aaaacggttt ttcggcatga ttcttgcaat 333181 catttcttca gaaacaaaca tttgaatgat tccggaaagt atgacgccaa tcagaataaa 333241 cggaatggct tctattaaaa tgctgataaa aatagaattc agctgaagaa aagatgattg 333301 tgctgtcaca ataaaacctc cgctcatgtt aagctgcctt tcttatgata ccagaaaaaa 333361 aggcactgct tgtttgacgg aggaggggaa aggatcgttt cactttggtt aggattccaa 333421 aaagccgagt aggatactgc ctgtttctgc agcttctttt ccgagccaaa tcaggtgtcc 333481 ccatgagtga agcaaacaga gaacagcgcc acgaatgtgc tcttttgcat gatgtgcatg 333541 tgacaagtca accaatccgt cataaacact ttgcataatc agcacgggac atatgatggc 333601 ttgcaggtct tttaaagaga cagcggcggt ttgtgacaag tcaatcagaa atccttcacc 333661 cgagcgctgc cggctgttca ttttccgaaa tgcttctatg tctttttcat tcatcaagga 333721 cttgattcgc tgaaacggaa gcgtgctgaa ttgggggctc atagctcgaa acatcaaacg 333781 cgggaaagcg ttattcaagg aagaaatcag cttccatatc cacttttcca ccggcgggcg 333841 gaagagaatt tcccccaatt tatattcagt gtcttttggg gtgagccact ctttggtgac 333901 tgcggattgc agggtcaatg tatttactct ttccggataa tgtgaggcaa agcatatgcc 333961 gctcggccct cctgctgaga tggcgatcac atggacactc tcgatttgta gatgatctaa 334021 taatttcaca tagaaacggc aggcattggc aagacttttt ccaatttctt ttgacgtccg 334081 tccatagcca ggccttgaag gcgtaatgat ggaataccct tgttcaatca acgctgtgta 334141 tccgaattcc tcgtaacaat ttgaatgccc gccatgcatg acaaggatcg gagttccctt 334201 gcctgtcaca gaatattcta gtgtaccgcc atcgaaggtg atcgtttcaa ctcgtctttt 334261 catctgtttc acccaattgg tttttgccta ttatagagtt ttcagcaatt gaccacaagg 334321 tagaagaaat gaataaacaa aggcccttga aatatgatat actttgtatt gatattcatt 334381 ctcaattaaa actttgatat agatgtgaac gggaggcagg acggatggct gagaatcaag 334441 aggtatatga cgttacgatt ataggcgggg ggccgatcgg gctgtttact gctttttact 334501 gcgggatgcg ggagctgaaa acaaaggtaa tcgaattttt gccgaagctc ggagggaagg 334561 tgtctttatt ctttcctgag aaaatcattc gcgatatcgg cggcataccg gggattgcgg 334621 gaaagcagct gatcgagcag ctgaaggagc aggcggcaac gtttgatcct gatatcgtat 334681 tgaatcagcg tgtgaccggg tttgaacgcc tagatgacgg caccattgtt ctgacgggtt 334741 ctgaagggaa aaagcactat acaagaactg tgattttggc ttgcggcatg ggtacacttg 334801 aggtcaatga gtttgacagc gaggatgcgg cccgatatgc gggcaaaaat cttcattatg 334861 gagtggagaa gctcgatgcg tttaaaggga aacgcgtggt gatatcaggc ggcggagata 334921 ctgcggtcga ttgggctaat gagcttgaac cgattgcggc gtctgtgact gtcgttcatc 334981 ggcgtgagga attcggcgga atggaaagca gcgtgacgaa aatgaagcaa tcatcggtgc 335041 gggtgcttac gccttatcgg ctggagcagt tgaacggaga tgaagagggc atcaaaagcg 335101 tgaccgtttg tcatactgag tctggccaga ggaaagacat agaaattgat gagctgatca 335161 ttaatcatgg gttcaaaatt gatctcgggc cgatgatgga gtgggggctg gagattgaag 335221 aaggaagggt gaaagctgac agacatatgc gaacgaatct tccgggcgtg tttgtggcgg 335281 gcgacgcggc tttttatgaa agcaagctga gattgattgc cggcggattt acggaaggcc 335341 cgacagcggt caacagtgcc aaggcttatc tggaccctaa ggccgagaat atggcgatgt 335401 attccaccca tcataaaaaa ttggtgcata aataaaacag cccttgagga aaagggctgc 335461 ttgccatcag gtgtgaagga gttttttctc tgcatgttga ttgtggatga aagctagcaa 335521 ttcatcctgt tcttgtacgg ctgtgaatcc ataaatgccg gcagctgagt catcgcctat 335581 gcagacgata ggagggcggc ttgctgacgg ttccggcaaa atgccaattt gttcgccacc 335641 attgatcaat tgctgaacgg acagcttgtt tgggcaaatg accatgtgca gcggggattc 335701 actgatggta cgctgaatca tgtgggtgaa ccggtcatct atgacgtttt catgagtgat 335761 ataaaacgaa caggattcat gcttttgcat gttttccact gcatggcggc tcccgacaac 335821 aagacgtttc tctgaatcag gctgaatggc ggtgacaaga aagccccgtt tctcaagctc 335881 tgtctttgct tgctcagatg ctgcactcag tttggctgtc agctggcgga tgtcgatttt 335941 ctgagaagcc agtgctctga aaaattcaca aaccgcccgg cgcgatgtga aaaaaacgtc 336001 ttcaaaggtg ccaatctttc gaagaatttc ttcattgaca ggcatgtttt cggtccgcca 336061 tttcggccac tcgatgagat cggcgccgga atcgcgcagc ttgtctgcaa gcgggtcttc 336121 atcttcgcca tgagtcacaa ccatcaaatg ccgtccgatg agcggtttgc tttcaaacca 336181 gctgtgtgtt tgaaagttga cgatgtctcc gatgacgata atcgcagggt ttgtaatctg 336241 gtgttcctgc actttttgct gaatgttctc aagtgttcct ttcacactcc gctggcggcc 336301 ccacgttccc cattggatga caatgacagg gacagaaggc gatttcccgt atgaaataag 336361 ctgctggcaa atataagaca agttcttgac acccatgtaa aaaacaaggg tttgaacgct 336421 tcgggccagc ccttcccagt caaggttcgg cgtgcctttt aatgatttat catgcgctgt 336481 aatcatggca aaagacgatg caaaatcccg atgcgtgacg gggatgcccg catatagcgg 336541 cgctgcaatt ccagaggtga ttcccggcac catttcatag cgaatgccgt gctcatgaag 336601 agcatctgct tcctcgccga ctctgccgaa tacgctcgga tctccgccct tcaagcgaac 336661 gacggttaac ccatttaatg ctttttcaac cagcagggcg ttaatttctt tttgtttcat 336721 aaaatggcgg tttggcagtt ttccgcaata aataaactgg cagtccggtg atgcaaattc 336781 gagcagcttc gggttggcga gccggtcata taaaatcaca tctgcttcct tgagcgcctg 336841 ttttcctttg atggtgagca ggcctgggtc gccgggtccg gctcccacga aatatacgat 336901 tccgttcttc atgatcatgt catccttccg tcactgtaaa aaatgaagga ccactagaaa 336961 agtgatccgg tcttttgatc aatatacgag ataaacatgt tctccttcga tcagcgtttc 337021 atatgttttg acgcatccgt ggtcaggttc ttggacgatt ccgtcttcta aggaaatttt 337081 ccagtcgtgc atcgggcaga aaacatattg accgctgacg atgccttctg ccaggacgcc 337141 gcccttatgc ggacagcggt tttcaatggc gcggatgctt ccgtctgaaa gcttgaaaac 337201 cgcgagctcc ttatcttcaa tatacactgt tttgcctaat tgttcaggca attcttcaat 337261 ttttccgata catacttttg ttacgtcttt gtttaccatg tccattcctc ctcaatgata 337321 gtttttgtca ttatgatgtg gtcacgacat tttcaaataa ttctttagag gtttgtttat 337381 cctctaaaaa gtctttccac ggatccttgt ggacagagag tgtttcattc attcggccgt 337441 tcagctcctg ccgcttttcc ggatcgttta acacggattg gacatgggat aaaccgacgc 337501 gctcaagcca tgcggacgta cgctccagat agtttgcggt ttccctgtaa tattgcaggt 337561 aagcgcccgc gtattctaag acttcttcat ttgttttcac cttcatcagc aaatcgccgg 337621 cacgcaaatg ggttccgccg tttccgccga cataaagctc ccagcctccg tcgatgccga 337681 caacgccaag gtccttaatg ccggattccg cacagtttcg cgggcaggca gacacggcca 337741 ttttgacttt gtgaggcgtg ttcagccctt cgaatttttt ctcaagcgca atgcccagtg 337801 ccatggagtc ttgtgtgccg aagcggcaga attgctcgcc tacacatgtt ttcactgtgc 337861 ggagcgtttt tccgtacgcg tagcccgatg gcatatcaag atcttcccat accttcggaa 337921 ggtcttcttt tttcacgccg ataagatcaa ttcgctggcc gcctgtcatt ttcacgagcg 337981 ggatctcata tttgtcaacg acatcggcga tcttgcgcaa atctgtggag ttggtcacgc 338041 cgccgtacat ccgaggaacg actgagtatg ttccgtcttt ttgaatattg gcgtgcattc 338101 gttcattaac aaagcgggat gtccggtcat cctcgtattt ggttggattg atcatgccta 338161 agtagtagtt cagagcgggt cggcatttag aacagccttc tggcgttttc cagccgagca 338221 cattcatgac ttctcttgta tgtgacagcc ctttggcttt gatttcttct acgacttcat 338281 ctctcgacaa tgtggtgcag ccgcaaatgg cttctttttg cgctgacgca tcaaagtctg 338341 atccgagcgt atgctggagg atttcttcta cgagcggctt acagcctccg catgagcggg 338401 atgcgccggt gcatgctttg atttcgtccg ttgacgagca gcccttttcc tgtatggctt 338461 gaataatcgc accttttgac acgccgttac agccgcagat gatttcatcg tcgctcatcg 338521 ctgcggttat gcttgtgcct gcttcctggc tgaggggctg taagattgat attttagagg 338581 tttcagagat atcggcttct ttttgaatca tagaaaacag gcgattgcct tcgctgctgt 338641 cgccgaataa aacagcaccg acaatttgat tgcctctcag gacaattttt ttatagatgc 338701 cgtcctgctc atcgaagact ttaatcgctt ttttctcctc tgattcgtta aagtcaccgg 338761 cagagaagac ctcgacgcct gataccttta actgtgtgga gagaacggag ccctcatacg 338821 gttttgtttc gatgccgcac atatgctttg ccagcacttt tgcctgttca tacagcggcg 338881 ccacaagccc gtaggcgatt cctcggtgct cggcacattc gccgaccgcg taaatgtgcg 338941 ggatttcagt ctgcatataa tcgttgacga tgatgccgcg gttaaccgga atgccgctct 339001 cggccccgag cgttgtattt gggcggatgc cgacagccat gacgactaaa tcagcttcaa 339061 tgcttgtgcc atccttgaat cggaggcctt cgacacggtc gtcaccgaca atttcttctg 339121 tttgcttttc aagtaaaaag gtcatacctt gtttttctaa ctcgttttgc agcaggcgtc 339181 ctgccgttgc atcaagctgg cgctccatca ggaatggggc aaggtggatg acggacacgt 339241 ccatgccgag attcagcagt ccgcgagctg cttccaaacc aagtagtcct ccgccgatga 339301 cggcagcttt tttatattgt tttgacgcgg cgagcattgt gtctgtatct tttatgtccc 339361 ggaaagctgt gacgcctttt ttgtctgcgc ccggaatcgg aaggataaaa gggaccgatc 339421 ctgtcgccag gatcaattca tcgtaaggct ggattctgtc tgcatctgtg atgactgttt 339481 tgttttccgt gtccactttg atgactgttt catttgtata caattgaatg ttgttttctt 339541 cgtaccagtc ccaatcgttt aacgtaatat ctttaatatc tgtatcgcct tgaagcactt 339601 ttgacaaaag gattcggttg taattgggat gcggttcggc accgaaaatt gtgatctgaa 339661 actcgtcttt agcaacactc agtatctctt caatggccct taccccggcc attccattac 339721 caacaagaac tagctgtttt tttcccatca gatgatccgc tccttatcaa atgttttttc 339781 cagcgtagca cagcaaaaag gaatatttaa gatacatgtt ataaaatgta acaaaatata 339841 cgaaaagttc taaaaatttt atgaaaaatt taaataggta tgattcggac ggcgcatacc 339901 ttaaaaccgg gcattttaca ggctggatct aaggcttccc cgattaaatc attcacattt 339961 tgagcgtctg cccaatggat gggaacaaaa acggtatctt ttctgatttg ttctgataat 340021 ttgctgcgga cggtgatgct tccccgcggc gattctattt ttaccagtac acggtcctcg 340081 atattgtagg tcgctgctgt ttgcggatgg atctccataa acgattcaaa atgtctcgcg 340141 gcaagggcgg cgctttttct tgtttggacg cctgttaagt agtgagacat gactctgcct 340201 gtcgttaaat aaagcggata atcggctgtc ggcttctctt ttggaacagg tggttcgttt 340261 ggaatcacac ttaatgccgc tttttgatcc ggatgagcaa atgattctgt aaacaagcgc 340321 ccagttccgg gatgatcaga ttccggacac ggccaatgaa tgccgccttc acgtctgagc 340381 ctgccgtatg agatgcctga ataatcggca atcccgcctc ggctcgcttc tctcaattca 340441 ttgaaaatat cctccgctga cgtataagaa aagtagcggc ccttgccgag agcggatgcg 340501 agatcacaaa tgatctgcca atcatgcttt gcttcgccgg ggcatggccg gcttgcttct 340561 cttaatgtca cgcgtccttc tacatttgtc atggtgcctt catcttctaa gtaagaggag 340621 gcaggtaaaa tcacatctgc gtatttcgca gtctcagaaa taaacaaatc gattgcgaca 340681 aagaatgtca gtcttcttaa agcctttttc acgagatttg catttggact ggaaacagca 340741 gggttggagc acatgaggaa cagtcctttg atgtcgccgt cattgatttt ttccatcatt 340801 tcataggctg agacaccttt tcgcgggagt tcatcctgat ggattcccca cactttcgca 340861 atatgcgccc ggtgttcttc gttttcgata gaacggtagc ctggaagctg atcggctttt 340921 tggccatgct ctctggcgcc ttgcccgttg ccttgtccgg tgatcgcccc gtagcccgag 340981 taaggtttgc cgatttttcc tgtgatcagc accatgttta agaagccttt cacagccgct 341041 gttccatcgg tttgctgttc aatcccgcgg gctgtaaaca gcatgccgga cgtttccttg 341101 gcaaacttca cagcagcttt tcttatatcc accagcgaga cactcgtctg ttcggcgatg 341161 tcattcaggt ccaacgagtc agtatgctgc ttcagctctt cgaatccatt tgttcgtgat 341221 tgaatgaaat cctcgtttat aagctgttcg tcaatgatga ttttgacgag accgttggca 341281 agggcggcgt ctgtgccggg tttgattttc agatgaagat cggcgatttt cgttgtcgct 341341 gtttcacgag gatcaatggc aatgaagtaa gctccgtttt ctttcgcttt ttcaaaatac 341401 ggcataatcg taggctggca ttccgcaata ttggtgccgg ccagaatgat cacacgggtg 341461 tgggggatgt ctgataaagg attcgttaag cctctgtccg cgccgaatgt ttggttggct 341521 gcggtggctg ctgcggacat acaaagtctc ccgttgtagt cgatgtattt tgtctgtaag 341581 cctactcgtg cgaacttccc taacaaatac gcctcttcat ttgtaatcga ggcgcttccg 341641 tataccgcca tggcgtcatg tccgtgttca gtttggatca ttgtcacttg gtctttgata 341701 tgattcagtg cttcttccca ggaaacaggc ataaactcgc cgtttttctt cagcagcggc 341761 cgggtgatgc gggaggagtt caaggcatgc tggtgagcat tcatgccctt gatgcatagc 341821 cgaccctgtg tcgtaggatt atcaatcccg atcgcagtgt actttttgcg cgtgacgatg 341881 gtttgttcca cgagctgcat tttgcactgc atgctgcaaa acgggcattg agtgtcatat 341941 gttttttctg attggacgtc ttgctgttta tcacggaaat atctaagcag tcgttcagtc 342001 aaaatgcctc atcctttctt atatgcgccc gtctctacag tcgggttttg aatcagtgac 342061 agatctgttt ggaggctttc cagcagctgt gcccttaggt cttcttcgaa tagcacttct 342121 ctgatatgaa cgatcccgag acggtctatc cactgatgaa caccttctaa gtaatgagcc 342181 gtttcccgat aatactggat cagtcctttg atcatgccgg cagtgctgtc ttcgttctca 342241 gtcacgcaaa acaaagctcc tgaacgggca tgagttcccc ggacgccgcc gatgtgaatg 342301 tcccagccag cttgtgtccg aattgcgccg acatcttgca gggcggcctc ggtgcagtct 342361 gtttcacatg ataagctgat agaaatggga gcgggtaagg gaagcatctc aagttgtctt 342421 tcgatttggg ctgccagctg ctgaatcgat cgattttgcc cgcatgtaca tgctttgatg 342481 ctttgcagcg cgtgtcggtg ttcattagtg taaacgggca ttttcaggtc ttttttcatg 342541 ttcgggagat ccgcaggctt gatcccggaa agcttcagcc tttggccgtg agtgatggat 342601 acgtcgggaa tgctgtatgc ctcaatgatg ttggcgatgg ttcttagctg ctccgcgttt 342661 gtccgcccgc cgtacatttg cggaatcagg atgcatgtct cttcagtggc tggctcaggc 342721 tggacaaacc cagggtacag catttccaga tagtattgaa tcgcaggaac acaagtactg 342781 catccgtttt ttgttttcca gtcaagctgg ttcatcactt ctgccggatt agtgaatggc 342841 ctgcgctgaa gctcagcgat gatgtcgtct tctgtaaaat cagtacagct gcaaaacgaa 342901 ggtgtgctgg cgggcttcgt atattcgctg ttggtcatgt atctcaaaag gtcttcaacg 342961 agcggtttgc atcctccgca ggacccagtg gctttggtgc agtgcttgac ttcctcaaca 343021 gttgttaagc tattcgtgtg caccgcgtct tcaatcgcgc ctttcgtcac tgtgttgcat 343081 tggcaaatcg tttcactgga aggcatggat tcaaataaag ggccgcttgt ctccggttcg 343141 atgatctgtt ttttggcaat ggagatgtct cgttgtttaa gcaggctgtc gagaagccgc 343201 tgcttgtcac gggtgtctcc gaataaaata acgccggcca gtttgtcatc tacaaaaagc 343261 gcttttttat aaacgcctgc ttgttcgtcg tagattttga tgctcgtcgt gcgttcatcc 343321 tcttggatct ttcctgctga ccacacatcg attccagcta tttttaacgc cgcagatggt 343381 gctgagcctt gatattcctc acatggaacg ccgcaaatat gactggcgag cgcttttccc 343441 tgctcataaa gcggagccac caatccgtac accgttccgt tatgctcagc gcattcacca 343501 acggcgtaga tattcggttc gcttgtctgc atgaagtcat tcacgatgat cccgcggttc 343561 actttgattc cagcggatac agccaattca atattcggtt tgacgccggc cgccatcaca 343621 atcaagtctg cttttaatga agagccatct ttaaaatgga ttcggtctgc cttcgtggcg 343681 ccggaaatgg agacggtgtc tttctccaaa agaaaggtta ggcctttttg ttccagctct 343741 gtttgcagca gccgcgccgc tgtttgatcg agctgttttt gcataatgcc ggcggagtgg 343801 tgaatgacgc tgacatccat accgagatgc tgtaaaccta ctgcagcttc cagtcctaat 343861 aagccggctc cgattaccgc agccttttga aagtgctggg ccatgttcat cagcgcttgg 343921 cagtcttcta ttgtccgaaa tccatagaca ccttttttgt ctgccccggg gatagggaga 343981 atatgagggg aggagcctgt tgccactatt aatttgtcat acgacagagt gcgtttccga 344041 tctgtgatga cctgctgctg atctgtatca atctgaataa ccgtttcgcc tgtgtaaagc 344101 gtgatcccgt gcttgtcgta ccaatccttg ctgttcagtg taatatcatc gagtgacgct 344161 tcaccctgca atacagagga taagagaatg cgattgtaat tgggatgcgg ctcgcttccg 344221 aaaatgacaa tctcaaacat gtggcgattc agctttaata cttcttcaat acagcggatt 344281 ccggccatgc cgtttcccgc taacactaat ctttgtttct tcatgtatca gacctccttt 344341 ggcgaagctc gtaagttttc tcctattaaa aattatgtca caatgcattg ttaacgcatt 344401 aaacgtgtca caaaaactta cacatgtctt ttccagaaaa taatggtcct atatccttga 344461 ttcagaaaat gtaaaataat gagggtctag aaaggggaat cttatgaagc tgtcggaact 344521 gaaaactagc ggtcatccac tcactttgct ctgttccttt ttatactttg atgtcagttt 344581 tatgatatgg gttatgcttg gggcgctggg tgtttatatt tctcaggatt ttggcctgtc 344641 tccttttgag aaagggcttg tcgtagctgt gccgatttta tctggatctg tgtttcgtat 344701 cattcttggt attttaacgg acagaatcgg accgaaaaaa acggcagtga tcgggatgct 344761 ggtgacgatg attccgctgc tttgggggac attcggcggc cgttccctga ctgagctgta 344821 tgccatcggg attctgcttg gcgtggcggg agcaagcttt gctgtagcgc tgcctatggc 344881 cagccgctgg tatccgcctc atttgcaggg acttgcgatg gggattgccg gagcggggaa 344941 cagcggcacg ttgtttgcaa ccctgtttgg ccctcgtctg gcagagcagt tcggctggca 345001 cattgtcatg ggaattgcgc taattccatt attgatcgtc tttattcttt ttgtatccat 345061 ggcaaaggat tcccctgcac agccgtctcc ccagccgctc aaaagctatc tgcatgtgtt 345121 tgggcaaaag gaaacatggt ttttctgcct gctgtacagc gtcacatttg gcggatttgt 345181 cgggctctca agctttttat ctattttctt tgttgatcaa taccagctgt caaaaattca 345241 cgcaggggac ttcgttacat tatgtgtggc ggcggggagc tttttccggc ctgtcggggg 345301 cttgatttca gatcgtgtcg gcggcacgaa agttctttct gtattgtttg tcatcgtggc 345361 actgtgtatg gccggagtca gtagcctgcc atctctctca atggttattg ttctattgtt 345421 tgtcggaatg atggggctcg gaatgggaaa cggcgcagta ttccagctcg tgccgcagcg 345481 cttccgcaaa gaaatcggca tggtgacggg aatcgtcggt gcggccggag gaatcggagg 345541 gtttttcttg ccgaacatct taggatctct caaacagatg acaggcacat atgctatcgg 345601 ttttatcacg ttttcctgta tcgcgctgct ggcgtttgca cttgtgcttg ccgcaggcta 345661 ttactggcgg aaaagctgga gcgcggaaag cagcccggcg gatgtttagg attttgacgg 345721 acacgcgttt gtgcgtgtct tttttatttt ctcttgattt tcaacagtga accgatcaaa 345781 ataaatagta attattacga tttgttagtg agaggagttt tctgaatgaa tcaacatacg 345841 ctgctcccga aaaaaacgga gcgtcttcaa tactttggat cggtcagtcc gatcaaaggc 345901 gagaaaccag tggaaaaaga gaaaatgaag gacctgcaaa atatcaggaa ggattatttt 345961 tttgacattc agcatgtagg tgtagctaat gtgtcccatc cagtcacaat cacttctgcc 346021 atgatgcctg ccgagcaaac aacggctgcg aactttacaa tgacttgtaa tttgccgaga 346081 aatcagaagg ggattaacat gagccggtta acagagctgc tgcaagtcta tcatcaaaat 346141 ggctggattc tctcattttc ctctcttcag caatttacga aagagcttgc agaaaacatg 346201 gacacatcat ctgccacagt tgaagtgagg tttccgtggt ttttcgaacg gaaaagcccg 346261 aagcttgaga aagcgggttt gatgcatgct gatatattca tgtctgtcac ctatcgcaaa 346321 gatcagccgt ttaaacagcg tgccggcatc tcagcaaaag taacgactct gtgcccttgc 346381 tccaaggaaa tcagcgaata cagtgcccat aatcagaggg gaacggtcag catttgggcg 346441 gatattcacc cggccgcatc gctgccaagt gatgttaaag ctgatttgct tcacgccgca 346501 gaatcaaatg cttctgcgag actgcatccg gtattgaagc ggcctgatga aaaagccgtg 346561 acagaaacgg cctatgaaaa cccgagattt gttgaggatc tcgcccggct gattgctgca 346621 gatttgtttg agcttgaatg ggtgtcagcc tttgagattg aatgccgaaa tgaagaatcg 346681 atccatcttc acgatgccta tgcgaagctg tgtttttcga aggaagtgga taaaatatga 346741 aactctcatt attcattatt gcagttctta tgccagtcat cctgctgtca gcctgctccg 346801 atcatgcaga agaacacgca agtatcaata caaagaaaac ggtcgaaaac ataacggacg 346861 ttcgaaaaac agcaaaaaca agcattgatt ggacaaagcc ttcgggcgga gaatacccgg 346921 atattaaaca gaagcatgtc tggattgatg tgaatgtgaa ggagcagaag gcttacatca 346981 aggaaggaag caacaccatc tatacaatga tgatttcttc tggtcttgat caaacaaaag 347041 atgatgctac gccaaagggc accttttatg tagagcctga acggggagaa tggtttttct 347101 ccgaaggata ccaggaaggc gcagaatact gggtatcatg gaaaaatcac ggtgaatttt 347161 tatttcatag tgtgccaatg actaaggatc aaaaagtcat caaaacggaa gcagaaaaac 347221 taggaacgaa agcatctcac ggatgtatca ggctgaccat tccagatgcg aaatgggtat 347281 atgaaaatat ccctgaacat acaaaagtgg tgatcagctg aattgaaaac cgttgacaaa 347341 aaggaaaaaa gaccatacaa tttaaatcgt aacaattacg ttttatgata aatggcttat 347401 cattgtctgt gcatctgtga aaagcggaaa ggcatcgatt aaggatcttg ctgtcggcaa 347461 aggcaaggat ttgcgatggg gaaaaggatt aaacgcggtt ggagtcttta ctgatttaga 347521 aatcgggcgg cagcgagaaa tgagcgcgaa aagctgctct acaccattgt acatacggcg 347581 aagtattcaa tttaaatcgt aatcattcta ttttaatgga ggcactatta tgaaaaaaat 347641 tccggttacc gtactgagcg gttatctcgg tgcgggaaaa acaacattgc tgaacagcat 347701 tttgcaaaat cgcgaaggct tgaaaatagc ggttatcgta aacgatatga gcgaggtgaa 347761 cattgacgcg ggcttggtta agcaggaagg tggcctttcc agaacagatg aaaagcttgt 347821 ggaaatgtca aatggctgca tttgctgcac gcttcgcgaa gacttattaa ttgaagttga 347881 gaagctggca aaagacggac ggtttgatta tatcgtcatc gaatcgacag gaatcagcga 347941 accgatcccg gtggcccaga ctttctctta tatcgatgaa gagatgggaa tcgatcttac 348001 aaaattctgt cagctggata cgatggtgac ggttgttgat gccaaccgtt tttggcatga 348061 ttatcagtca ggcgaaagcc ttctggaccg caaagaagca ttgggggaaa aggatgaaag 348121 agaaatcgcc gacctcttga tcgatcaaat tgagttttgc gatgtactga tcttaaataa 348181 atgtgatttg gtcagcgagc aagagctcga acagcttgaa aacgttcttc gtaaactgca 348241 gccaagagcc aggttcattc gttccgtcaa aggaaatgta aaaccgcagg agattttgca 348301 tacagggtta tttaacttcg aggaagcgag cggatcggcc ggctggattc aagagctgac 348361 ggcaggccat gcggaacaca ccccggaaac agaagaatac ggtatctctt catttgtata 348421 taagagacgt ttgccgtttc attctacacg attttaccgt tggttggatc aaatgccaaa 348481 gaacgtggta cgtgccaaag gaatcgtctg gtgcgcatct cataacaacc tcgctttgct 348541 gatgtcgcaa gcaggtccgt cggttacgat tgagcctgta tcttattggg tggcggcgtt 348601 gccgaagctt gagcaggagc aagtcaaaca gcaggagccg gaaatcctgg aggagtggga 348661 cccggagttc ggcgaccgcc taacgcagct agtttttatc ggaactgacc tggatgaaga 348721 aacgatcacg aaagagcttg atcaatgcct gttgactgag tatgaatttg attccgactg 348781 gtcgctgttt gaggacccgt ttaaatggaa gctgaatcaa tagaaaaaaa gccgtcccat 348841 ggggaacggc tttttttaat gaaacgtttg tttaaacata atgagcgtat tttttctcaa 348901 ggatattctg aaagaccgcg gcaatggagc agatggccca ataaatgaga gcggtcagaa 348961 tatacatggt catataatca aactctctgc ccccgatgat tttcgcatgc tggagcaatt 349021 ccggcactgt aatcatcgca gcgagagagg acgccttgat caagtcgagc aatacattgg 349081 caagcggagg cagcgcaata cgtatcgatt gcggcaaaat gatgcccctc atcgtctgcc 349141 aataggaaag acccagcgag gatgcggctt cccactgtcc tttttcgacg gatgaaatgg 349201 ctgaacggtt aatttccgca atgtaggcgg cgctgtttag gctaaagccg attaaagcag 349261 ccgtgacagc ggaaaattca atgccgatat aaggaaaccc gaaataaagg ataaacaaaa 349321 tcaccaaaat cggaacgcct cgcataaatg agatatagag cttcgccggc catcttaaca 349381 aagcaagttt agacattctg gcgagtgata tgaacaggcc gatcacagtt cccgcaaaca 349441 tgcttacaaa agagatgagc agtgtataac caatgccttt tatgacataa gggaacgatt 349501 caatggccag cttcgtgttg aaaatatatt cccactgaat gctattgatc atggcgtccg 349561 attacaaatc aacgtcctga acgtcggcat caattttttt tgatacatct gctttattga 349621 agaattgttt cgacagttta gtcaaagagc catccttgct catctctttc aatgcttcgt 349681 tcatcttttt ctgaagtgcc gcattgcttt ttttcatgac aagggcctgt ttgttcggca 349741 tgtacttgat gtcaggatga attgtaatgt tgagatccgg gaatgccgcg agcgcaagtg 349801 tctgcaggta atagtcgttt aaaatgacgt cagtgcgtcc gttggcaaca tcttttaaat 349861 attgctcatt cgtcgcatta tcataaatca cttctttggc gccgtatttt ctcgcgacct 349921 ccatgtagac ggttgtagcc gcgccagccg ctttcttccc ttttaaatcc ttgagcgttt 349981 taatccctga taaatcgtct tttcggacaa ttgccgtgcc gtatgaatat ttatatggag 350041 tggaaaatgc gaacttctcc tcacggtcct tcgtcacatc gatgtcattc gcggctgcgt 350101 caacctgtcc gctgttcacc gctgtcagca tcccgtcaat gcccatctcc ttgaactcaa 350161 ccttcagccc caagcgtttt gccgcttcac gaacaacttc aacctcgtag cccgtcagct 350221 tatcagagcc agagtcagta tcgtgataag aagtgggata gagcgtacct gatgtagcga 350281 ctacgatttt ccctttatcc ttaatctgct cccagcctgt atccttggaa tcggcttcat 350341 ttttgccgga acaggctgcc aatataagaa agaaagccat tgtgaaactg aatataacgg 350401 ctttggaatg catgaatgat ttcacctata gttcccccaa tctgttaatc aactaaaaag 350461 atagcattga acataagggg ttgcaatatg ttgatcgcgt tttcaaaaag ttcgaattgt 350521 gtatacaaaa agcatgggtg ggtgtttaaa agcgtctatg aagggaagag gtgatgaaaa 350581 aaggaattgt ccaaggatga atgccagacg taccaaggaa acgcatgtga aagtgaagga 350641 tgcagcagac ccgtcactca tctatgccaa taccggaaga aatggtcaag aggcatgaaa 350701 ccgatcttca gaataaattt aagtcttgct gatgccccta aggcatatga tatattcgat 350761 gagaaagaaa atggaaacat ttaaaccata atggggagtc aaatgaatat ttacaaacca 350821 gccggatttt ggatcagact tggagctgca ttgttagact acattatagt ctccgtgccg 350881 cttttgctga tctattggct gattacagga aaagacccaa acgacagcat gttcatcagt 350941 ttggttgttc tgctgtattc tattttgctg ccgatgtttt ggcgcggtta tcttatcgga 351001 aaaaggatct gcggaatcag aatcgtaaaa aaagacggat cacaggtcag tctgttaaca 351061 atgtttttac gggttattgt agccggcctg gtttactgta taaccttcgg actcggcttg 351121 atcgccagcc tgattctgat tgccgtacga gaagacaaac ggaccctgca tgatttaatc 351181 gcgggaacat atgtcactta tgcgacacca ggtgaagagg aacttaatgc tgacgaagag 351241 attagaaaga gcgaataatg gttcgctctt tttattttta tgcataaaaa atacaaggca 351301 gcaaaacata tgaaaaatag gattggagga ataaaatgga tgaaacgaat aaccatcaac 351361 attatcacaa tgttcattgc agcggctgtc atttctctga ccggtacagc tgaggccgct 351421 gaaaaacagc agcagtctcc cgcaaatgtt acactgacag atcagcaaaa gaaagagatt 351481 gaacaactgg aagcagagat tcttaaaaag cgcaaagacg tgatctcaaa gtatgtacaa 351541 tacggtatcc tgcctaaaga aagaggagaa cacatcaaaa atcacttgga caaacacttt 351601 gaaatgatga aacaaaacgg ctttgttcca aagcaccatc ctcatccgca taaatttgaa 351661 aaaagacatt aagattttaa gcatccaatg ggaattgggt gcttttgcgt tatttacagg 351721 taggcaatat tagctgagct gttccgcgac taacatcgag ttgatatgaa acgcgtttca 351781 tagcctatga taggtttatc aaataattca ggagtgataa acactatgat ccaccagcat 351841 ccagaatctt ttccgaaaca ttttttgtgg ggctctgctt ctgcagcgta ccagattgaa 351901 ggcgcttgga atgaagatgg caaaggccct tctgtttggg atgtgtttac gaaaataccg 351961 ggcaaaacgt ttaaaggaac caatggcgag attgcggttg accattatca ccgatttaaa 352021 gaagatgtcg ctctgatggc tgagatgggg ttaaaagcat atcgattttc cgtcagctgg 352081 ccacgggttt ttccaaaagg aaaaggagag atcaatgaag caggtctagc gttttacgat 352141 agtctgattg atgaattgct ttctcatcac atcgagccgg ttctgacttt atatcactgg 352201 gatttgcctc aagcgcttat ggacgaatac ggcgggtttg aatccagaaa catcatagag 352261 gattttaatc actactgtat tactctttat aaacgttttg gagacagggt gaaatattgg 352321 gttacgttaa acgaacagaa ctacaatttt aatcacggat ttattacagc catgcatccg 352381 cctggagtga aagacagaaa acgattttac gaagcaaacc atattgcgtt tctggctaat 352441 gcaaaagcca tcgaatcatt tagagaatat gtgcctgaag gcaaaatagg tcctagcttt 352501 gcttattctc cggcttaccc tttatcaagt catccagagg atatactggc atttgaaaac 352561 gccgaagaat ttacgaacaa ttggtggctt gacatgtatt gctggggaac ctacccgcaa 352621 attccattcc gctgcttgga aaaacaggga tgggcgccga caattgaagc aggagatatg 352681 gacctgctcg ccaaagggaa gcctgatttt gtaggtgtca attattatca gacgatcacc 352741 tatgaacgaa atccgcttga tggtgtgtca gaagggaaaa tgaatacgac aggccaaaag 352801 ggaaccaatc aggagacggg gatacccgga gtgttcaaaa cgaaaaaaaa tccgcatctg 352861 acaacgagca actgggattg gacaattgac ccaattgggc tgcgtatcgg tcttcgccga 352921 attacaagcc gctatcagct tccagtgttt ataacagaga acggtttggg tgaatttgat 352981 aaagttgagg acggcactgt acaggatgat tatcgaattg attatttgcg ttcgcatctt 353041 gagcaatgca gacaagccat cagtgacggt gtcgatttaa tcggctattg cagctggtcg 353101 tttactgatc tgttaagctg gctgaacggc taccaaaaaa gatacggatt tgtatatgtc 353161 aatcgtgatg aagaaagcac atccgattta aaacgcttga agaaaaaaag cttttattgg 353221 tatcaagatg tcatcaagac aaacggagaa agtttataaa gagtccctga gagttattct 353281 ctcaggggtt tttcattaca cagaaacagc atcaataata taagtgtcgg cgtgcaaatc 353341 tgacatttca gccggcacag tccagcatgt caattgatag tctcctttag gcagatcaaa 353401 ggacagtctt ttagacatga tgctttcaat atgaattccg ttttctgtga catgaaaagg 353461 aacagtcact tttttttcgt aggagtttac tgtttctgaa ctgttcaggc gaaaaagaat 353521 aaaggccttt gtatttcgct gtgcctcaaa ggaaatggct ccgtctgccg cagcatatcc 353581 tttttcaatc gcttcgtcag tccaatccat tacaggaggt gtagaatcct tttgaaatac 353641 agtaaattga tgatatgaaa tcgaaagttc ttgcggcttc catgatttga tcaatgtgct 353701 gttcctcctc tatgtactgt ttactgaatt gtgaataaaa cctttgtgcc gtctgggtaa 353761 tcggtaagcc gatgcccgac ccaagagcct gctccgcggt tgtcagcggg agaaatgtat 353821 tctacagaag ctccctcacc gccttctttg cacatggcca ttggccattc atctctgtca 353881 tacccctttt tggaaggtac gtcctttaat gattgctcgc ggcgttcttc agctccgtct 353941 ctgtcaatag tgcacacctc tgagtgcccc tcatttatcg catccttaat atgcttggca 354001 gtttcgggat accggtcaga tgggaaggcc attgtttcat catattcttt cgtttgagac 354061 gttttttgat cagctgagaa aaagtctcct tttatcaggc cgacagctgc agctgctatg 354121 atgacgatga cgagaagtat cgtttttatg atgtccgtcg tgatgttcac ctcccgcttt 354181 taaaactgac acaagagtaa tccagaaagc atttggtgta aaggtttaaa ttttatgttt 354241 tacgatcagt ttattgcaga aatcgtaatt ttagcagatc gaaatatttg ttttcagcaa 354301 aatacgattg ccaatttaca ataatgatag taagtcatca gccgttttcg gcttgattaa 354361 tcattttaaa ttggcttatg ataccggtaa gctcctcagc taattgagaa agtgtttcag 354421 aagctgcggt aatctcctcc attgcagcaa attgctcctc tgttaatgca gccgcttgcc 354481 gggtattttt agtagattct ttaatgtcgg ccgtattggc tgcaaaggaa tcatttattt 354541 gatgtgcact ggctgaaatg tttgttacag atgctgataa atcactaatc tcggcgctga 354601 tttcacctgt tgcagctgca atttccttaa atgcatctct ggtgcgctgg atcatggtga 354661 ctccttctgc agcttctgtt ttcacatgct caacagatct tgcagaccgg ttcatatcct 354721 tttgtatttc tatgatcagt tttgaaatct gccccgcaga ctgttgagac tcttctgcta 354781 atttccgtac ttcatcagca acaacagcaa agccttttcc ttgttcaccg gctctggcag 354841 cttcaatcgc tgcattcagc gcaagcaggt ttgtctgatc agcaatttgg gtgatgaccg 354901 ataaaatttg ctcaatttgt ttagagcggc cgtctaactg gtgtatgatt tctccgcttt 354961 tctgaattga ctggtgaatc gcatccattt gcgcctgtac atttgcaatt tccttttgtc 355021 caatgtctgc ttttgattga gcgagctgcc ctttgtcagc gatagcggca gtatttgcag 355081 aaatatcccg gatgtctgct gaagcttgtt ttaatgagct ttcactattt tcaattcggg 355141 tgatctgatc ttgggctcca tttgcaatct gctgtacagc ttctgtgatt ttttctgaag 355201 cttgatttgt ttcctctgct ccggctgaga gctgctgaga ggctgacgca agctgaaggg 355261 ctgattgttg tacggtttgt atggtatcgt tcagcttcat tctcatctta ttataataga 355321 cgcttagttc tgaaagctcg tcaccggttt tgtctgacac ctctattgtc atatctccgt 355381 ttccggcact ttcaaaggcg ctttttaaag cgttcagccg cttgttgatt tttctggtga 355441 aaaccaagac aaggatgact gataccataa tgacgataac aagaacgata gcgaattgag 355501 tgaaaagtga ttgtgtaagt gatgctaaaa tactttgatt agctccggta tacagcatgc 355561 cgatgatgtt cccattttga tcttttaacg gcatgtatgc agtctgataa gaagaacctg 355621 ctacatctgc ttgtccgtaa aaacgctttc ctttctttaa aacagcggca ataacttcag 355681 aagaagcctg ggtgccgacg gctctttcgc catttttcat gacattggtt gcaacacgag 355741 tatcgccttg gaaaatggta atggtatcac ctgtcttttc accaagcaga tcaacaatat 355801 cttcatttcc attgatttgt gtttgccctt tatagagctt attgtttttc acctgccagt 355861 cgcctgacat gacatcatca atataagtgc tgcttaaagc gagatcacct ttcgcttttt 355921 cagttgccat ttgtttcatg ctttctgtaa tttccttaag catcacagtg ccaactgatg 355981 ccgaaaacaa aagaatcacc acgaaaacga ggcaaagaat tttagttcct agcttcatct 356041 taaatcgttt tatcaacata attcctccct ttacgatttg caggtcatat tacttatcgg 356101 gtttttgggt ttaaagtttt attttagaaa aaataaaacc ggcctgatct tcaggccggt 356161 tgtgtgatgc tattcaaggt ttgcgtggtg agtgaacata gtttcagaat cgagaccttt 356221 tttctccatg agttttaaaa tcactgcatc atagaagagc agcaaagttt gttcaaataa 356281 tgatcccatt ggctgaatgg ttttatagct tccgttagac tggtctttag gggaaccagg 356341 cattctgatg atgaggtccg cttgttttcc gatgcttgat tccggattga tggttaaagc 356401 ggcaacaatt ccgtgtaagc tttttgcttt tgctgcggta tgaatcaagc tctttgtctc 356461 gcctgatcct gagccgataa taactagatc tccttcggcg agcggcggag tgagaatctc 356521 acctactata tgggcgttga agcccatgtg catcagtctc atcgcgaagg attttgccat 356581 caggccagac cgccccgcac ccgcggtgaa aatttggtgg gatgaaagaa tgtgatcggc 356641 aagctggtca gcttcttcat tagaaatata agctgctgaa ttgtgtaact cattgagaat 356701 ttccgctacg tattcagtcg ttttcatcgg agttatcctt ggacaatcag ctgcttcatt 356761 tttgaagctg tttccgcctt atcagctgcg cttgtaattc cgcccccgac aatgacaagg 356821 tcaggctttt gctggatcac ttctggcagt gtatcaagtt tgatgccgcc cgcgattgcg 356881 gtttttgcgt tttttacggt atttttgatt gtcgttaatt cttcgaaaga gtttttgccc 356941 tctgcttgaa gatcatagcc agtgtggacg cagatgtagt caacaccgag tgcgtcaatt 357001 tctttcgcac gggattcgat atctttcacg ttaatcatgt ccactaagat tttcttcttt 357061 tgttttttgg cttcttctac tgcgccttta atcgttgcat cgtctgtagc ccctaaaacg 357121 gtgatgatgt cagcgcctgc ttccgacgct ttcataattt cgtagcctcc ggcatccatg 357181 attttcaggt ctgcaagaac cttcaattga ggaaatgctt cttttatttc tttaacggct 357241 cttaggcctt cattgatgac gaccggtgtt ccgatttcaa ctacgtcgat gtattgttct 357301 acctctttga caagctcaat ggcttccggg atgttgacga ggtctaatgc aagctgtaat 357361 tccattgttg atccactccc tttttcgaat tattgttcat tctataggtt ccttcttttg 357421 ttgagaagta ggcactttga agtcaacaag ttacttggag gatactgtga ggagagacaa 357481 tcagatttct ttcgcttgat tttatgagtg agtataatga aaaaagagtc tgcaaaaaag 357541 taagtaagtg atgatacgta tctaacatac aaaaaggtta ctaagggggg ggattctatt 357601 gagccggatg gacgacaaaa ggtttaattg tgagaaggaa ttaacgcttg cagtgattgg 357661 cggtaaatgg aaaatgctca ttttatggca tttaggaaaa gaaggcacaa aacggttcaa 357721 tgaattaaaa acattgattc ctgatattac gcagaagatc ctcgtgaatc agctgagaga 357781 gcttgagcag gatatgattg ttcacaggga agtgtatcca gttgtcccgc cgaaggttga 357841 atattctctg accccgcacg gagaaagcct catgcctatt cttgaagcca tgtatgagtg 357901 ggggaaaggc tatatggaat tgattgatat cgacaaaaat gtcatgaaag aatcgttgta 357961 agacgctctt cgcaagggtg tctttttttg cctttttttc ggtttttgcg cggtacacat 358021 agtcatgtaa agattgtaaa ttgcattcag caataaaaaa agattgaacg cagcagtttg 358081 gtttaaaaat ttttattttt ctgtaaataa tgtttagtgg aaatgattgc ggcatcccgc 358141 aaaaaatatt gctgtaaata aactggaatc tttcggcatc ccgcatgaaa cttttcaccc 358201 atttttcggt gataaaaaca tttttttcat ttaaactgaa cggtagaaag ataaaaaata 358261 ttgaaaacaa tgaataaata gccaaaattg gtttcttatt agggtggggt cttgcggtct 358321 ttatccgctt atgttaaacg ccgcaatgct gactgacggc agcctgcttt aatagcggcc 358381 atctgttttt tgattggaag cactgctttt taagtgtagt actttgggct atttcggctg 358441 ttagttcata agaattaaaa gctgatatgg ataagaaaga gaaaatgcgt tgcacatgtt 358501 cactgcttat aaagattagg ggaggtatga caatatggaa ataacttttt accctttaac 358561 ggatgcacaa aaacgaattt ggtacacaga aaaattttat cctcacacga gcatttcaaa 358621 tcttgcgggg attggtaagc tggtttcagc tgatgcgatt gattatgtgc ttgttgagca 358681 ggcgattcaa gagtttattc gcagaaatga cgccatgcgc cttcggttgc ggctagatga 358741 aaacggggag cctgttcaat atattagcga gtatcggcct gttgatataa aacatactga 358801 cactactgaa gatccgaatg cgatagagtt tatttcacaa tggagccggg aggaaacgaa 358861 gaaacctttg ccgctatacg attgtgattt gttccgtttt tccttgttca ccataaagga 358921 aaatgaagtg tggttttacg caaatgttca tcacgtgatt tctgatggta tctccatgaa 358981 tattctcggg aatgcgatca tgcacattta tttagaatta gccagcggct cagagacaaa 359041 agaaggaatc tcgcattcat ttatcgatca tgttttatct gaacaggaat atgctcaatc 359101 gaagcggttt gaaaaggaca aggcgttttg gaacaaacaa tttgaatcgg tgcctgaact 359161 tgtttccttg aaacggaatg catccgcagg gggaagttta gatgctgaga ggttctctaa 359221 agatgtgcct gaagcgcttc atcagcagat tctgtcgttt tgtgaggcga ataaagtcag 359281 tgttctttcg gtatttcaat cgctgctcgc cgcctatttg tacagggtca gcggccagaa 359341 tgatgttgtg acgggaacat ttatgggcaa ccggacaaat gcgaaagaga agcagatgct 359401 tggcatgttt gtttctacgg ttccgcttcg gacaaacatt gacggcgggc aggcgttttc 359461 agaatttgtc aaagaccgga tgaaggatct gatgaagaca cttcgccacc aaaagtatcc 359521 gtataatctc ctaatcaacg atttgcgtga aacaaagagc tctctgacca agctgttcac 359581 ggtttctctt gaatatcaag tgatgcagtg gcagaaagaa gaggatcttg cctttttgac 359641 tgagccgatt ttcagcggca gcggattaaa tgatgtctca attcatgtaa aggatcgatg 359701 ggatactggg aaactcacca tagattttga ttaccgcact gatttatttt cacgtgaaga 359761 aatcaacatg atttgtgagc gcatgattac catgctggag aacgcgttaa cgcatccaga 359821 acatacaatt gatgaattaa cactgatttc tgatgcggag aaagagaagc tgcttgcgag 359881 ggccggcggt aaatctgtga gctaccgtaa ggacatgacg ataccagagc tgttccaaga 359941 aaaggctgaa ctgctttctg atcatccagc ggttgtattt gaagatcgca cattgtccta 360001 tcgaacgtta catgagcaat ctgcacgcat cgccaatgtg ctgaaacaga aaggggttgg 360061 cccggacagt cctgtcgcgg ttttgattga acgctctgaa cggatgatta cagctatcat 360121 gggaatttta aaagccggcg gagcctatgt gccgattgat ccgggttttc ctgctgagcg 360181 cattcaatat attttggagg actgcggggc ggatttcatc ctgactgaat cgaaggttgc 360241 ggcgcctgaa gccgatgctg agctgattga cttagatcag gcgattgagg aaggtgcaga 360301 agaaagcctg aatgcagatg tgaacgctcg gaaccttgcc tacattattt acacatcggg 360361 aacaaccgga cgcccgaaag gcgttatgat cgagcatcgc caggttcatc atttggttga 360421 atctctgcag cagacgattt atcaaagcgg cagccaaacc ctgcggatgg cattgcttgc 360481 gccgttccac tttgatgcgt cagtgaagca gatcttcgcg tcgcttcttt tgggccaaac 360541 cctttatatc gtaccgaaga aaacagtgac gaacggggcc gcccttactg catattatcg 360601 gaagaacagc attgaggcga cggacggaac accggctcat ttgcaaatgc tggcagcagc 360661 aggcgatttt gaaggcctaa aactgaagca catgctgatc ggaggagaag gcctgtcatc 360721 tgttgttgcg gacaagctgc tgaagctgtt taaagaagcc ggcacagcgc cgcgtttgac 360781 taatgtgtac gggccgactg aaacgtgcgt tgacgcgtct gttcatccgg ttatccctga 360841 gaatgcagtt caatcagcgt atgtgccgat cgggaaagcg ctggggaata accgcttata 360901 tattttggat caaaaaggcc ggctgcagcc tgaaggcgtg gcgggtgagc tttatatcgc 360961 gggagacggt gtgggccgag gctatttaca tttgcctgaa ttaacggaag agaagttttt 361021 acaagatcca ttcgtgccgg gcgatcgcat gtaccggacc ggggacgtgg tgcgctggct 361081 tccagatgga acaatcgaat atttaggcag agaggatgac caggtcaaag tccgcggata 361141 ccggattgag cttggggaaa ttgaagccgt gattcagcag gcgccagacg ttgcaaaagc 361201 cgttgttttg gcacgccctg acgaacaggg aaatcttgag gtttgcgcat atgttgtgca 361261 gaagcctgga agcgaatttg cgccagccgg tttgagggag catgcggcca gacagcttcc 361321 tgactatatg gtgccggctt actttacaga agtgacagaa attccgctta caccaagcgg 361381 caaagtcgac cgccgcaagc tgtttgcact agaggtgaag gctgtcagcg gcactgccta 361441 tacagcgccg cgaaatgaga ctgaaaaagc aatcgcagcc atttggcagg acgtgctgaa 361501 cgttgagaag gcggggatct ttgacaattt ctttgaaact ggcggacatt cattaaaagc 361561 catgaccctt ttaacaaaga ttcataagga aacaggcatt gagattccgc ttcaattttt 361621 gtttgagcat ccgacgatta cggctcttgc agaggaagct gatcacagag aaagcaaagc 361681 ttttgcggtg attgaacctg ctgaaaaaca ggagcattac ccgctttcat tggcacagca 361741 gcgaacatat atcgtcagcc agttcgagga tgcgggagtc ggctataaca tgccagcagc 361801 agcaattctg gaagggcctt tagatattca aaagctggag cgcgcatttc agggattaat 361861 ccgacgccac gagtcattga gaacatcatt tgttcttgaa aacagcacgc cgagacagaa 361921 aattcacgat agcgttgatt tcaacatcga aatgattgaa agaggcggcc gctcagatga 361981 ggcaattatg gcttcattcg ttcggacatt tgatttggcg aaagctccgc tgttcagaat 362041 cggtttgctg gggcttgaag agaaccgtca tatgctgctg tttgacatgc accatttgat 362101 ttctgacggt gtatccattg gcattatgct ggaggagtta gcacgcattt ataaaggcga 362161 acagcttcct gatcttcgtc tccagtataa ggactacgct gtatggcaaa gcagacaggc 362221 tgctgaaggg tacaagaagg accaggctta ttggaaggaa gtctttgcag gcgagctccc 362281 ggtgcttcag cttctgtccg attacccaag accacctgtt caaagctttg aaggggatcg 362341 ggtgtcaatc aagctggatg cgggggtaaa ggatcgcctc aatcgtttgg ctgaacaaaa 362401 cggcgccact ttatatatgg tgatgctttc cgcttactat acgcttttgt caaagtatac 362461 ggggcaggat gacatcattg tcgggacacc gtcagcgggc agaaatcact ccgatacaga 362521 gggcattatc gggatgttcg tcaatacgct tgcgattcgc agtgaggtga agcagaatga 362581 gacgtttacc caattgatct cgcgtgtccg caaacgggtg ctggatgcct tttctcatca 362641 ggactatccg tttgagtggc ttgttgaaga tttgaacatc ccgcgtgatg ttagcaggca 362701 tccgctgttt gacacgatgt tcagccttca aaacgcgaca gagggcattc cggctgtcgg 362761 cgatctttcc ttgtctgttc aagagaccaa tttcaagatt gccaaatttg atttgacggt 362821 gcaggcgaga gaaaccgatg aaggcattga gattgatgtg gattacagca caaagctgtt 362881 taaacaaagc acggcagaca ggctgcttac gcattttgcg cgtttgcttg aagatgctgc 362941 ggctgatcca gagaagccga tttctgagta taagcttctt tctgaagagg aggctgcttc 363001 gcaaattcag cagtttaacc cgggcagaac accttatccg aaagataaaa caattgttca 363061 gctgtttgag gagcaagcgg cgaatacgcc agaccacact gcgcttcaat atgaaggcga 363121 atcactcact tatcgtgaac tgaatgaacg ggccaatcgt ttagcccgcg gcattctttc 363181 tcttggagct ggcgaaggca gaactgcggc tgtcttatgc gagcggtcaa tggatatgat 363241 tgtgtcgatc ttggcagtat taaaatcagg ttcggcttat gttccgatcg atccggaaca 363301 tccgattcag cggatgcagc atttcttccg tgacagcgga gcaaaggtgc ttctcactca 363361 gaggaaatta aaggctttgg cggaagaagc ggaatttaag ggcgttatcg tgctagccga 363421 tgaggaagaa agctatcatg ccgatgcgcg aaatctcgca ctgcctcttg attctgcagc 363481 aatggccaac ctgacgtata cttccggaac gactggaaca cctaagggga atatcgtgac 363541 acatgccaat attctccgca cggtgaagga aacgaattat ctcagcatta cagaacagga 363601 tacgattctc ggtctttcca attacgtgtt tgacgcgttt atgttcgata tgttcggctc 363661 tttgttaaac ggagccaagc tggtgctgat accgaaggaa accgttttgg acatggctcg 363721 cctgtcccgc gtcattgaac gggagaacat cagcattctc atgattacaa ccgctttgtt 363781 ccacttgctt gtggacttga atccggcatg cttgtcaacg cttcgcaaga ttatgtttgg 363841 cggggaacgg gcttcggttg agcatgtcag aaaagctttg caaacggttg gaaagggcaa 363901 gctccttcat atgtatggac cgtctgaaag cacggttttc gcgacgtatc atccggttga 363961 tgaattggag gagcacacgc tgtctgttcc gattggaaaa ccggtcagca atacggaagt 364021 atacattctt gaccgtacgg gacacgtgca gcctgccggg attgccggag agctttgcgt 364081 cagcggcgaa ggactcgtga aaggctatta caaccgtcca gaactgactg aggagaaatt 364141 tgttccccat ccgtttacat ccggcgaacg catgtataaa acgggagacc ttgcgagatg 364201 gctgccgaat ggcgacatcg aatttatcgg gcgaatcgac catcaggtga agattcgcgg 364261 acagcgcatc gagcttggag aaatcgaaca tcagctgcaa acccatgatc gtgttcagga 364321 aagtgttgtg cttgccgttg atcaaggagc gggagataaa ctgttgtgtg cttactatgt 364381 cggagaagga gacatctcat cacaagagat gagagagcat gctgcgaagg acttgccggc 364441 atatatggtt cctgcggtgt ttatccaaat ggacgagctg ccgctgacag ggaacggaaa 364501 aattgaccgg agagcgctgc cgattcctga tgccaacgtt tcaagaggtg tttcatatgt 364561 tgcgccacgc aatggaacgg aacaaaaagt cgcggacatt tgggcacagg tacttcaggc 364621 agaacaagtc ggcgcttatg accacttctt tgacattggc ggacattcat tagcaggcat 364681 gaagatgctt gccttggttc atcaggaact gggcgttgag ctgtcactca aggatctctt 364741 ccagtcaccg acggttgagg gcttggcaca ggtgattgcc tctgctgaaa aagggacagc 364801 cgcaagtatc agcccggcag agaaacaaga tacgtatcct gtttcttcac cgcaaaaacg 364861 gatgtacgtg cttcagcagc ttgaggatgc gcaaacgagc tataacatgc cggcggttct 364921 gcgcctgaca ggtgagcttg atgttgaaag gcttaacagc gtcatgcagc agttaatgca 364981 gcgtcatgaa gccttgagaa ccacgtttga aataaaagat ggagaaacgg tgcagcggat 365041 ctgggaagag gctgagtgcg agatagccta tttcgaagcc ccggaagaag agacagagcg 365101 gatcgtttct gagtttatta agcctttcaa aatcgaccaa cttccactgt tcagaatagg 365161 gcttatcaag cattcagaca ctgagcatgt gctgctgttc gatatgcatc atattatttc 365221 tgatggtgca tctgtcggtg tgctgattga ggagctttca aagctgtacg acggagaaac 365281 ccttgagccg ctccgtattc aatataagga ttatgccgtg tggcagcagc agttcattca 365341 gtctgagctt tacaagaagc aagaagagca ttggctgaag gagctggacg gagagctgcc 365401 ggtgctgacg cttccgactg attacagtcg gcctgccgtt caaacatttg agggagaccg 365461 cattgcattt tcattagaag caggcaaagc tgatgctctg cgcaggcttg caaaagaaac 365521 ggattccacg ctttacatgg tgcttctggc ttcatacagt gcgtttttat caaaaattag 365581 cgggcaagac gatatcatcg tcggttcacc tgtggccgga cgatctcaag cggacgtcag 365641 ccgcgtcatc ggaatgttcg tcaatacatt ggcgctgcgc acgtatccga agggtgaaaa 365701 gacgtttgct gactatctta acgaagtgaa agaaacggca ctcagcgctt ttgatgcgca 365761 ggattaccca cttgaggatt tgatcggaaa tgttcaggtt cagcgtgaca caagcagaaa 365821 tccgttattc gatgcagttt tttcaatgca aaatgcgaat ataaaggatt taacaatgaa 365881 agggattcag cttgagccgc atccgtttga acggaaaaca gccaagtttg acctcacgct 365941 gacggctgac gaaaccgacg gagggcttac attcgtactc gaatacaata cagctctgtt 366001 taagcaggaa acgattgaac gatggaagca atattggatg gagcttttag atgcagttac 366061 tgggaacccg aaccagccgc tttccagcct gtcactggtc accgagacag aaaagcaagc 366121 gcttcttgag gcatggaagg gcaaagcgct gcctgtgccg acagacaaaa cggttcatca 366181 gctattcgaa gagactgccc agcgccacaa agaccgcccg gctgtcacat acaacggcca 366241 gtcttggacg tacggcgagc tgaatgcgaa ggcaaaccgt ctcgcgcgga ttctgatgga 366301 ctgcggcatc agcccggatg accgcgtcgg cgttctcacg aagccgtcgc ttgaaatgtc 366361 cgccgcggtg ctcggcgtct tgaaagccgg agcggcgttt gtgccgattg atcctgacta 366421 tccggatcag cggattgagt atattttaca ggacagcggc gcgaagcttc tcttgaaaca 366481 ggaaggcatt tcagtgccgg acagctatac gggagatgtc attcttctcg acggaagccg 366541 cacgattcta agcctgccgc ttgatgaaaa cgacgaggaa aatccagaaa ccgctgtaac 366601 cgcggagaac ttggcgtaca tgatttacac gtctggaacg accggacagc cgaagggtgt 366661 catggtcgag caccatgcgc ttgtgaacct gtgcttctgg caccacgacg cgttcagcat 366721 gacagcggag gaccgcagtg cgaagtacgc gggctttggg ttcgacgctt ccatttggga 366781 gatgttcccg acctggacga tcggtgccga acttcacgtc attgaggaag cgatccgcct 366841 cgatatcgtc cgcctgaacg attattttga aacgaacggc gtaacgatca cgttcctgcc 366901 gacacagctt gcggaacagt tcatggagct tgagaacaca tcacttcgcg tattgcttac 366961 tggaggagac aagctgaagc gcgcagtgaa aaagccgtac acactcgtca ataactacgg 367021 gccgacagag aatacggtcg ttgccacaag cgcagaaatc catccggagg aaggctcgct 367081 ttccatcgga agggccattg ccaatacgag agtatacatt ctcggcgagg gcaatcaggt 367141 gcagccggaa ggcgtagccg gagagctttg cgtggcgggg cgcggactgg cacgcggcta 367201 tctgaatcga gaagacgaaa ccgcgaagcg gtttgtcgct gatccgtttg tgccgggtga 367261 gcgcatgtac cgcaccggcg atttggtgaa atggacgggc ggcggcatcg aatacatcgg 367321 ccggatcgac cagcaggtca aggtccgcgg ctaccggatc gagctctcag aaattgaagt 367381 ccagctcgcc cagctttctg aggtgcagga tgcggcggtg acagctgtca aagataaagg 367441 cggcaacaca gcgatcgcgg cgtatgtcac accggaatca gctgacatag aagcactgaa 367501 atcagcactg aaggaaaccc tgccggatta catgatcccg gcgttctggg tgacgctgaa 367561 cgagcttccg gttacggcaa acggcaaagt ggaccgcaaa gccttgcctg agccggacat 367621 cgaagcggga agcggagaat acaaagcgcc gacgaccgac atggaagagc tgcttgccgg 367681 catctggcag gacgtgcttg gaatgtctga agtcggtgtc accgacaatt tcttctcgct 367741 tggcggagat tccatcaaag gaattcaaat ggcgagccgc ttgaaccagc acggctggaa 367801 gctggaaatg aaagatctct tccagcaccc gacgatcgaa gagctcaccc agtacgtaga 367861 gcgtgccgaa ggcaaacagg cagaccaagg cccggtggag ggcgaagtca tcctgacgcc 367921 gatccagcgc tggttctttg aaaagaactt cacgaacaag caccactgga accaatctgt 367981 gatgcttcac gccaagaagg gctttgatcc tgaacgggtg gagaaaacat tgcaggcgct 368041 gatcgagcat catgacgcgc tccgcatggt ctatcgtgag ggacaggaag acgtcattca 368101 atacaacaga ggtcttgaag ctgcttcagc tcaattggag gtcatccaga ttgagggcca 368161 agctgcagat tacgaagacc gaatagagag agaagcggag cgtttgcaaa gcagcatcga 368221 cttgcaggaa ggcggcttgt taaaagcagg cttgttccaa gcggaagacg gagatcactt 368281 gcttcttgcc attcaccact tagtggttga cggcgtgtcg tggcggattt tactggagga 368341 tttcgccgcg gtatatacac agcttgagca aggcaatgaa ccggttctcc cgcagaaaac 368401 acattcattt gcagagtatg cagagagatt gcaagacttc gcgaactcca aagccttttt 368461 gaaagaaaaa gagtattgga gacagcttga agaacaagct gttgcggcaa agcttccgaa 368521 agaccgcgaa tctggtgatc agcgaatgaa acatacaaag acaattgaat tctcgctgac 368581 tgctgaagag acagaacagc tcaccacaaa ggtgcatgag gcatatcaca cagaaatgaa 368641 tgatattttg ctgacggcat tcggattggc aatgaaggag tggacgggtc aagatcgagt 368701 aagtgttcat ttagaggggc atggacgtga agaaatcata gaagacctga ccatttctcg 368761 cacagtcggc tggtttacaa gtatgtaccc aatggtgctc gatatgaagc atgcggatga 368821 tctgggctac cagctgaagc aaatgaaaga agatatcaga catgtgccga ataagggagt 368881 cggatacggc attctgcgct atctgacggc accggaacat aaagaagatg tggcgttctc 368941 gattcagccg gatgtcagct tcaactattt aggtcagttt gacgaaatgt cggatgcagg 369001 tttgtttacg agatcagagc tgccatcagg acagtcatta agccctgaaa cagaaaaacc 369061 gaatgcgctg gatgttgtcg gatatatcga aaacggaaaa ctgacgatgt cactggccta 369121 tcattctctt gaatttcatg aaaaaacagt acaaacattc agtgacagct ttaaagcgca 369181 tcttctcaga atcattgaac attgcctatc tcaagatggt acggaactga ccccgagtga 369241 tcttggtgac gacgatttga cgctggatga gctggataaa ttaatggaaa ttttctaata 369301 gaggtggcat atgagcaaaa aatcgattca aaaggtgtac gcactgacac caatgcagga 369361 gggaatgctg tatcatgcga tgcttgatcc gcattcttcc tcgtacttca cacaattaga 369421 gcttgggatt cacggcgctt ttgatcttga aatctttgag aaaagcgtca atgaactgat 369481 tcggtcatac gatattctcc gtacggtatt tgtgcatcag cagctgcaaa aaccgcgtca 369541 ggtcgtgtta gcggaacgca aaacaaaagt gcattatgag gatatcagtc atgcagacga 369601 aaaccgccag aaagagcaca ttgagcgtta caaacaagac gttcagcgcc aaggctttaa 369661 cctggcaaaa gacatattgt tcaaggtagc ggttttccgc cttgctgcag atcagctgta 369721 tcttgtctgg agcaatcatc atattatgat ggacggctgg agcatgggcg tcctcatgaa 369781 aagcctgttc caaaactatg aagcgctcag agcaggcagg acaccggcaa acggtcaggg 369841 caagccttat tccgattaca tcaagtggct tggaaaacag gacaatgaag aagcggagag 369901 ctactggagc gagcgcttgg cgggttttga acagccaagc gtgctcccgg gccgcctgcc 369961 tgtgaaaaaa gacgaatacg tcaataaaga atattcattt acatgggacg aaacactggt 370021 tgcccgtatt cagcaaaccg caaatctcca tcaagtgaca gggcctaacc tatttcaggc 370081 cgtttggggc attgttctca gcaaatacaa ctttacggat gatgtgatct tcggaacggt 370141 cgtctcggga cgaccgtctg aaatcaacgg aatcgaaacg atggcggggc tgtttatcaa 370201 caccattcca gtgcgggtga aagttgaacg agatgctgca ttcgctgata ttttcacagc 370261 tgttcagcag catgcagtag aggcagagcg ttacgattac gtgccgctct atgagattca 370321 aaaacgctca gctcttgatg gcaatctctt aaaccatctg gtcgcgtttg aaaattatcc 370381 gcttgatcaa gagcttgaaa acggcagcat ggaagaccgc ctcgggtttt cgattaaggt 370441 agaaagcgca tttgaacaaa cgagcttcga tttcaacctg attgtgtatc cgggcaaaac 370501 gtggaccgtc aaaattaaat ataacggagc cgcctttgat tccgctttta tcgaacggac 370561 agcggagcac cttacccgca tgatggaagc agctgtcgat cagccggccg cttttgtgcg 370621 tgagtacggg cttgtgggag acgaagagca gcggcaaatt gtcgaggtgt ttaacagcac 370681 gaaagccgaa ctccctgaag gaatggctgt tcaccaagtg tttgaagagc aagcgaaacg 370741 gacgccggcg agcaccgccg tcgtatatga aggaaccaag ctgacgtacc gcgagctgaa 370801 tgcagcggct aaccgtctgg cgagaaagct tgtcgaacat gggcttcaaa aaggggaaac 370861 agcagcgatt atgaacgacc gctcagtaga aaccgttgtc ggcatgctgg ctgttttaaa 370921 agcaggcgcc gcatatgtgc cgcttgatcc agcgcttcct ggggatcgtc ttcgtttcat 370981 ggcagaggac agctccgttc gaatggtttt gatcggaaat tcttatacag ggcaggcaca 371041 tcagctgcaa gtgccggttc ttacactgga cataggcttt gaagagagtg aagcggctga 371101 caatctcaac ctgccatccg ccccgtctga tttggcgtac atcatgtaca catccggttc 371161 aacgggcaaa ccgaaaggcg tcatgatcga acataaaagc attctgcgcc tcgtcaaaaa 371221 tgccgggtac gttcctgtta ctgaagaaga ccgcatggcg caaacgggag ctgtcagctt 371281 tgatgccgga acgtttgagg tattcggcgc actgctgaat ggcgcagcac tttatccggt 371341 caaaaaagag acactgcttg atgcgaaaca atttgctgca ttcctgcgtg agcaaagcat 371401 cacaactatg tggctgacat cacctttatt caaccagctt gctgcaaagg atgcgggtat 371461 gttcggcaca ctgcgccatt taatcatcgg cggagatgcc cttgtcccgc atattgtcag 371521 caaagtaaaa caggcatcgc cgtcgctttc attgtggaac ggatacggcc cgacagaaaa 371581 cacgacgttt tcaaccagtt ttctgatcga ccgcgagtat ggcggctcta tcccaatcgg 371641 gaagccgatc ggaaattcca ctgcctatat tatggatgag cagcaatgcc tgcagccaat 371701 cggcgcgcct ggtgagcttt gcgtaggcgg aatcggtgta gcgcgtgggt atgtcaatct 371761 ccctgagctg acggagaagc aatttctgga agacccgttc agaccgggtg agagaattta 371821 ccgcactggt gacttggcaa gatggctgcc ggacggcaat atcgaatttt taggcagaat 371881 cgacaaccaa gtgaaggtgc gcggcttccg aattgagctt ggcgaaattg aaacaaaact 371941 gaacatggct gagcatgtga cagaagccgc ggtgatcata cgcaagaaca aagcagacga 372001 aaatgaaatt tgcgcgtact tcacggcgga tcgtgaagtg gctgtgagtg agctgagaaa 372061 aacactgtct cagtctttgc ctgactatat ggtccctgcc cacctgattc aaatggacag 372121 cctgccgctc acgccaaacg ggaaaatcaa caaaaaggaa ctgcctgcac cgcaatcaga 372181 agccgtgcag ccggaatacg cagcaccaaa aacagagagt gaaaagaaat tagcggagat 372241 ctgggaagga atactcggcg tcaaagcagg cgttaccgat aacttcttta tgatcggcgg 372301 ccattctttg aaagcgatga tgatgacggc gaaaattcaa gagcattttc ataaggaagt 372361 tccgataaaa gtgctttttg aaaagccgac tattcaagaa ctggcactgt atttggaaga 372421 gaacgaaagc aaggaggagc agacgtttga accgatcagg caagcatctt atcagcagca 372481 ttatcctgta tccccggccc agcggagaat gtatatcctc aatcagcttg gacaagcaaa 372541 cacaagctac aacgtccccg ctgtacttct gctggaggga gaagtagata aagaccggct 372601 tgaaaacgcg attcagcaat taatcaaccg gcacgaaatc ctccgtacat cgtttgacat 372661 gatcgacgga gaggttgtgc aaaccgttca taaaaacata tcgttccagc tggaggctgc 372721 caagggacgg gaagaagacg cggaagagat aatcaaagca tttgttcagc cgtttgaatt 372781 aaaccgcgcg ccgctcgtcc gttcgaagct tgtccagctg gaagaaaaac gccacctgct 372841 gctcattgat atgcatcata ttattactga cggaagttca acaggcattc taatcggtga 372901 tcttgccaaa atatatcaag gcgcagatct ggaactgcca caaattcact ataaagatta 372961 cgcagtttgg cacaaagaac aaactaatta tcaaaaagat gaggaatact ggctcgatgt 373021 ctttaaaggc gaactgccaa tactggatct tcccgcggat ttcgagcggc cagctgaacg 373081 gagctttgcg ggagagcgcg tgatgtttgg gcttgataag caaatcacgg ctcaaatcaa 373141 atcgctcatg gcagaaacag atacgacaat gtacatgttt ttgctggcgg cgttcaatgt 373201 actcctttcc aagtacgcgt cacaggatga tatcattgtc ggctcgccga cagctggcag 373261 aacacatcct gatctgcaag gtgtgccggg tatgtttgtc aacacggtgg cactcagaac 373321 ggcaccagcg ggagataaaa ccttcgcgca attccttgaa gaggtcaaaa cagccagcct 373381 tcaagcattc gagcaccaga gctatccgct tgaggagctg attgaaaagc ttccgcttac 373441 aagggataca agcagaagtc cgctgttcag cgtgatgttc aacatgcaga atatggagat 373501 tccttcatta agattaggag atttgaagat ttcctcgtat tccatgcttc atcatgttgc 373561 gaaatttgat ctttccttgg aagcggtcga gcgtgaagag gatatcggcc taagctttga 373621 ctatgcgact gccttgttta aggacgagac gatccgccgc tggagccgcc actttgtcaa 373681 tatcatcaaa gcggccgcgg ctaatccgaa cgttcggctg tctgatgtag atctgctttc 373741 atctgcagaa acggctgctt tgctagaaga aagacatatg actcaaatta ccgaagcaac 373801 ctttgcagca ctttttgaaa aacaggccca gcaaacacct gaccattctg cggtgaaggc 373861 tggcggaaat ctgttgacct atcgcgagct tgatgaacag gcgaaccagc tggcgcatca 373921 tcttcgtgcc caaggggcag gaaatgaaga catcgtcgcg attgttatgg accggtcagc 373981 tgaagtcatg gtatccattc tcggtgtcat gaaggcgggg gcagctttcc ttccgattga 374041 tcctgataca cctgaagaac gaatccgtta ttcattagag gacagcggag caaaatttgc 374101 ggtcgtgaat gaaagaaaca tgacggctat tgggcaatat gaagggataa ttgtcagcct 374161 tgatgacggt aaatggagaa atgaaagcaa ggagcgccca tcatccattt ccgggtctcg 374221 caatcttgca tacgtcattt atacgtccgg tacgaccgga aagccaaagg gcgtgcagat 374281 tgagcatcgt aatctgacaa actatgtctc ttggtttagt gaagaggcgg gcctgacgga 374341 aaatgataag actgtattgc tttcatctta cgcatttgac cttggctata cgagcatgtt 374401 ccctgtactt ctgggcgggg gcgagctcca tatcgtccag aaggaaacct atacggcgcc 374461 ggatgaaata gcgcactata tcaaggagca tgggatcact tatatcaagc tgacaccgtc 374521 tctgttccat acaatagtga acaccgccag ttttgcaaaa gatgcgaact ttgaatcctt 374581 gcgcttgatc gtcttgggag gagaaaaaat catcccgact gatgttatcg ccttccgtaa 374641 gatgtatgga cataccgaat ttatcaatca ctacggcccg acagaagcaa cgatcggcgc 374701 catcgccggg cgggttgatc tgtatgagcc ggatgcattt gcgaaacgcc cgacaatcgg 374761 acgcccgatt gcgaatgccg gtgcgcttgt cttaaatgaa gcattgaagc ttgtgccgcc 374821 tggagcgagc ggacagctct atatcacggg acaggggctc gcgagagggt atctcaacag 374881 gcctcagctg acagccgaga gatttgtaga aaatccatat tcgccgggaa gcctcatgta 374941 caaaaccgga gatgtcgtac gaagactttc tgacggtacg cttgcattta tcggccgggc 375001 tgatgatcag gtgaaaatcc gaggctaccg cattgagccg aaagaaattg aaacggtcat 375061 gctcagcctc agcggaattc aagaagcggt tgtactagcg gtttccgagg gcggtcttca 375121 agagctttgc gcgtattata cgtcggatca agatattgaa aaagcagagc tccggtacca 375181 gctttcccta acactgccgt ctcatatgat tcctgctttc tttgtgcagg ttgacgcgat 375241 tccgctgacg gcaaacggaa aaaccgacag aaacgctctg ccgaagccta acgcggcaca 375301 atccggaggc aaggccttgg ccgcaccgga gacagcgctt gaagaaagtt tatgccgcat 375361 ttggcagaaa acgcttggca tagaagccat cggcattgat gacaattttt tcgatttagg 375421 cggccattca ttaaaaggga tgatgctgat tgccaacatt caggcggaat tggagaaaag 375481 cgtaccgctt aaagcactgt tcgagcagcc gacagttcgc cagctggcgg cttatatgga 375541 ggcgtctgct gtttcaggcg gccatcaagt actcaaaccg gctgacaagc aggatatgta 375601 tccattgtca tccgcacaga aacgaatgta cgtgctcaat cagcttgacc gccagacgat 375661 aagctacaac atgccatctg ttcttctaat ggaaggagag cttgatattt cgcgcctgcg 375721 cgactcactc aatcagcttg tgaaccgtca cgaatcattg cggacgtcat ttatggaagc 375781 taatggtgag cctgttcagc gcatcattga gaaggcggag gttgatcttc atgtgtttga 375841 agccaaagaa gacgaagcgg accaaaagat taaggaattt atccggccat tcgacttaaa 375901 cgacgcaccg ctcattcgcg cagctttgct tcgaatagaa gcgaaaaaac atttgctgct 375961 tttagatatg catcatatca tcgcagacgg cgtctcaaga ggcatctttg taaaagaatt 376021 ggcgctgctt tacaaaggag agcagcttcc ggagccgacg cttcattata aagatttcgc 376081 cgtttggcaa aatgaagctg agcaaaaaga acggatgaag gagcatgagg cgtactggat 376141 gtcagttctt tcaggcgagc tgccagagct tgatctcccg ctcgattatg cccgtccgcc 376201 tgtgcaaagc tttaaaggag atacgatccg tttccgtacg ggaagtgaga cggcaaaggc 376261 ggtagaaaaa ctgcttgccg aaaccggaac gaccttgcac atggtgctcc atgctgtttt 376321 ccacgtcttt ttaagcaaaa tttccggaca gcgggatatc gtcatcggct ccgttactgc 376381 cggccggacg aatgctgatg ttcaggacat gccgggaatg ttcgtcaata cacttgccct 376441 gagaatggaa gcgaaagaac agcaaacatt tgcggagctt ttggagctag caaagcagac 376501 gaacctgtca gcccttgagc atcaggagta tccgtttgaa gatctggtta atcagcttga 376561 tctccctcgg gatatgagcc gaaacccatt gtttaatgtg atggtgacga cagaaaaccc 376621 tgataaagaa cagcttacat tgcaaaatct gagcatttca ccttatgagg ctcatcaggg 376681 aacttctaag tttgatctga cactgggcgg atttactgat gaaaatggca ttggcttgca 376741 gctcgaatat gcgacagatc tgttcgcaaa agaaacagct gaaaaatgga gcgaatacgt 376801 tctgcggcta ctaaaggctg ttgcggataa cccgaaccag ccgctttcca gtctgttact 376861 ggtcaccgag acagaaaagc aagcgcttct tgaggcatgg aagggcaaag cgctgcctgt 376921 gccgacagac aaaacggttc atcagctatt cgaagagact gtccagcgcc acaaagaccg 376981 cccggctgtc acatacaacg gccaatcttg gacgtacggc gagctgaacg cgaaggcaaa 377041 ccgcctcgcc cggattctga tggactgcgg catcagcccg gatgaccgcg tcggcgttct 377101 cacgaagccg tcgcttgaaa tgtccgccgc ggtgctcggc gtcttgaaag ccggagcggc 377161 gtttgtgccg attgatcctg actacccgga tcagcggatt gagtatattt tacaggacag 377221 cggcgcgaag cttctcttga aacaggaagg catttcagtg ccggacagct atacgggaga 377281 tgtcattctt ctcgacggaa gccgcacgat tctaagcctg ccgcttgatg aaaacgacga 377341 gggaaatcca gaaaccgctg taaccgcgga gaacttggcg tacatgattt acacgtctgg 377401 aacgaccgga cagccgaagg gtgtcatggt cgagcaccat gcgcttgtga acctgtgctt 377461 ctggcaccac gacgcgttca gcatgacagc ggaggaccgc agtgcgaagt acgcgggctt 377521 cgggttcgac gcttccattt gggagatgtt cccgacctgg acgatcggcg ctgaacttca 377581 cgtcattgat gaagcgatcc gcctcgatat cgtccgcctg aacgattatt ttgaaacgaa 377641 cggcgtaacg atcacgttcc tgccgacaca gcttgcggaa cagttcatgg agcttgagaa 377701 cacatcactt cgcgtcctct tgaccggagg agacaagctg aagcgggcag tgaaaaagcc 377761 gtacacactc gtcaacaact acgggccgac agaaaatacg gtcgttgcca caagcgcaga 377821 aatccatccg gaggaaggct cgctttccat cggacgggcc attgccaata cgagagtata 377881 cattctcggc gagggcaatc aggtgcagcc ggaaggcgta gccggagagc tttgcgtggc 377941 ggggcgcgga ctggcacgag gctatctgaa tcgagaagac gaaaccgcga agcggtttgt 378001 cgctgatccg tttgtgccgg gtgaacgcat gtaccgcacc ggcgacttgg tgaagtgggt 378061 gaacggcggc atcgaataca tcggccggat cgaccagcag gtcaaggtcc gcggctaccg 378121 gatcgagctc tcagaaattg aagtccagct cgcccagctt tctgaggtgc aggatgcggc 378181 ggtgacagct gtcaaagata aaggcggcaa tacagcgatc gcggcgtatg tcacaccgga 378241 aacagctgac atagaagcac taaaatcaac actaaaggaa accctgccgg attacatgat 378301 cccggcgttc tgggtgacgc tgaacgagct tccggttacg gcaaacggca aagtcgaccg 378361 caaagccttg cctgagccgg acatcgaagc gggaagcgga gaatacaaag cgccgacgac 378421 cgacatggaa gagctgcttg ccggcatctg gcaggacgtg cttggaatgt ctgaagtcgg 378481 tgtcaccgac aatttcttct cgcttggcgg agattccatc aaaggaattc aaatggcgag 378541 ccgcttgaat cagcacggct ggaagctgga aatgaaagat ctcttccagc atccgacgat 378601 cgaagagctc acccagtacg tagagcgtgc cgaaggcaaa caggcagacc aaggcccggt 378661 ggagggcgaa gtcatcctga cgccgatcca gcgctggttc tttgaaaaga acttcacgaa 378721 caagcaccac tggaaccaat cggtgatgct tcacgccaaa aagggctttg atcctgaacg 378781 ggtggagaaa acattgcagg cgctgatcga gcatcatgac gcgctccgca tggtctaccg 378841 cgaggaaaac ggggacatcg ttcaggtgta taaaccgatc ggtgagagca aggtcagctt 378901 cgaaatcgtg gatctgtacg gctccgatga agagatgctg agaagccaga ttaagcttct 378961 cgcgaacaag ctgcaaagca gtctcgatct gcgaaacggg ccgcttttaa aggcggagca 379021 atatcgcaca gaagctgggg atcacctgct cattgctgta caccatctcg tggtcgacgg 379081 tgtgtcatgg cggattttgc ttgaagactt tgcttcaggc tacatgcagg ctgagaaaga 379141 agagagcctt gtcttcccgc aaaaaacaaa ctccttcaag gattgggcgg aagaactggc 379201 ggcattcagc caatcagcgc atcttttaca gcaggctgaa tactggtcgc aaattgccgc 379261 tgaacaggtt tctcctttac ctaaggattg tgaaacagag cagcggatcg tcaaggatac 379321 atcatctgtc ctatgtgaat taacggcaga agacactaag catcttttaa cagatgttca 379381 tcagccatat ggaactgaaa tcaacgatat tcttctcagc gcgctcggtt tgacaatgaa 379441 agaatggaca aagggggcca aaattggcat taaccttgag ggacacggcc gggaggacat 379501 tatcccgaat gtgaatatct ccagaacggt cggctggttt acggcacaat accctgttgt 379561 gctcgacata tctgacgcag atgcctcagc tgtgatcaaa acagtcaaag aaaacctgcg 379621 ccgcattccg gacaaaggtg ttggctacgg cattcttcgt tatttcacag aaacagcgga 379681 aacaaagggc ttcacaccgg agatcagctt caactatttg ggccaattcg acagtgaagt 379741 caaaaccgat ttctttgaac cgtccgcttt cgatatgggg cgccaagtaa gcggagaatc 379801 agaggcgctg tacgcattaa gcttcagcgg catgatcaga aacggccggt ttgtgctttc 379861 ctgctcctac aatgagaagg agtttgaaag agctacagtc gaggagcaaa tggaacggtt 379921 taaagaaaac ctcctgatgc taatccgcca ttgcacggaa aaagaagaca aggaattcac 379981 accaagcgac ttcagcgccg aagaccttga aatggacgag atgggagata tctttgacat 380041 gcttgaggag aatttaaaat aaaacgcaag ggaattacag aaggcgggag cgaaacatat 380101 gagtcaattt agcaaggatc aggttcaaga tatgtattac ctatcgccga tgcaggaagg 380161 gatgcttttt catgccatcc tgaatcccgg ccaaagcttt taccttgaac aaatcacgat 380221 gaaagtaaaa ggcagcttga atatcaaatg tcttgaagaa agcatgaatg tgatcatgga 380281 ccggtacgat gtatttcgta ccgtgttcat tcacgaaaaa gtaaaaaggc ctgtccaagt 380341 cgtattgaaa aaacggcagt tccatataga agaaatcgat ctgacacact taacgggcag 380401 cgagcaaaca gccaaaatca atgagtacaa agaacaggat aagatcaggg gttttgattt 380461 gacgcgggat attccgatgc gggcagccat tttcaagaaa gctgaagaaa gctttgaatg 380521 ggtgtggagc taccaccaca ttattttgga cggatggtgc ttcggcatcg tcgtacagga 380581 tctatttaag gtatacaatg ctctgcgcga acaaaagccg tacagcctgc cgcccgtcaa 380641 accgtataaa gactacatca agtggcttga aaagcaggat aaacaagcat cactgcgtta 380701 ctggcgcgaa tatttagagg gctttgaagg acaaacgacg tttgcggagc aaagaaagaa 380761 acaaaaggac ggctatgagc cgaaagagct gctcttttca ctgtcggagg cggaaacaaa 380821 ggcctttacc gagcttgcaa aatcgcagca taccactttg agtacggcgc tgcaggcagt 380881 ctggagcgta ttgatcagcc gctatcagca gtctggcgat ttggccttcg gtacagttgt 380941 ttcagggcgt cccgcggaaa tcaaaggcgt tgaacatatg gtcgggctgt ttatcaacgt 381001 tgtcccgaga cgtgtgaagc tgtctgaggg tatcacattt aacggcttgc tcaagcggct 381061 gcaggagcaa tcgctgcagt ccgagccgca tcaatatgtg ccgctttatg acatccaaag 381121 ccaggccgat cagccgaaac tgattgacca catcattgtt tttgagaact atccgcttca 381181 ggatgcgaaa aatgaagaaa gcagtgaaaa cggctttgat atggtggatg ttcatgtttt 381241 tgagaagtcg aattatgatc tcaacctgat ggcttccccg ggagatgaga tgctgattaa 381301 gcttgcctat aatgagaatg tgtttgatga ggcgtttatc ctgcgcttga aatctcagct 381361 tcttacagca attcagcagc tcatccagaa tcctgatcag cctgtcagca cgatcaacct 381421 cgttgacgac agggagagag aatttttgct aaccggctta aacccgccgg ctcaagctca 381481 tgaaacaaag cctctgacgt attggttcaa ggaagcagtg aacgccaatc cggatgcacc 381541 ggcgcttacg tattccggcc agaccctgtc ttatcgcgaa ttagatgagg aagcgaaccg 381601 cattgcacgc cggctgcaaa aacacggtgc gggcaaaggc tctgttgtag cgctgtacac 381661 gaagcgctca cttgaactgg tgatcggcat tctcggtgta ttaaaggcgg gagcagccta 381721 tctgccggtt gatccgaagc tgccagagga ccgaatctcg tatatgctgg ctgacagtgc 381781 ggcagcctgt cttctgacgc atcaggagat gaaagaacaa gcggctgagc tgccgtatac 381841 aggcacaacg ctcttcattg atgatcaaac acggtttgaa gaacaggcaa gcgatcctgc 381901 aaccgcgatt gatcctaatg atccggcata tatcatgtac acgtccggca caaccggaaa 381961 gccaaagggc aatatcacca ctcatgccaa tattcaagga ttggtcaagc atgtagacta 382021 catggcattt tctgatcagg atacgttctt gtctgtttcg aattacgcct ttgatgcatt 382081 tacctttgat ttctatgctt ctatgctgaa tgcggcacgg ctcattatcg cagatgaaca 382141 tacgctgctt gatacagaac ggctcacaga tctgatcctg caagagaatg tcaatgtcat 382201 gtttgcgaca accgcactat ttaatcttct cacagatgcg ggagaggatt ggatgaaggg 382261 gcttcgctgt atattattcg gcggagagcg cgcgtcagtg cctcatgtca gaaaagcgct 382321 gcggatcatg gggccgggca agctgattaa ctgctacggg ccgactgagg gaacagtgtt 382381 tgcgacagct cacgtcgtgc atgatctgcc ggattccatc tcctcattgc cgatcggaaa 382441 gccgatcagc aatgccagtg tttatattct gaatgagcaa agccagctcc agccattcgg 382501 ggcggtcggt gaactgtgca tcagcggaat gggcgtgtca aaagggtatg taaatcgtgc 382561 tgacctcacg aaggaaaagt ttatcgagaa cccgttcaag ccgggagaaa cgctttaccg 382621 tacaggggat ttagcgcgct ggctgccgga tggaacgatt gaatacgccg gccgtattga 382681 cgaccaggtc aaaatacgcg gacaccggat tgagcttgaa gaaatcgaaa agcagctgca 382741 ggaataccca ggtgtgaaag atgcggtcgt tgtggcggac cgccatgagt ctggcgatgc 382801 atcaatcaat gcctaccttg tgaaccgaac gcagctttca gctgaagacg tgaaggcgca 382861 cctgaaaaaa cagcttcctg cttacatggt gccgcaaacc tttaccttct tggatgagct 382921 tcctttaacg acgaacggga aagtcaataa acggctgctc ccaaaacctg atcaggatca 382981 gctggcggaa gaatggattg gaccgcggaa cgagatggaa gaaacaatcg cacaaatatg 383041 gtctgaggtt ctcggcagaa agcaaattgg cattcatgac gatttctttg cgctcggagg 383101 gcattccttg aaggccatga ccgccgcgtc ccgcatcaag aaagagctcg ggattgatct 383161 tccagtgaag cttttgtttg aagcgccgac gatcgccggc atttcagcgt atttgaaaaa 383221 cgggggctct gatggcttgc aggatgtaac gataatgaat caggatcagg agcagatcat 383281 tttcgcattt ccgccggttc tgggctatgg ccttatgtac caaaatctgt ccagccgctt 383341 gccgtcatac aagctatgcg cctttgattt tattgaggag gaagaccggc ttgaccgcta 383401 tgcggatttg atccagaagc tgcagccgga agggccttta acattgtttg gatattcagc 383461 gggatgcagc ctggcgtttg aagctgcgaa aaagcttgag gaacaaggcc gtattgttca 383521 gcggatcatc atggtggatt cctataaaaa acaaggtgtc agtgatctgg acggacgcac 383581 ggttgaaagt gatgtcgaag cgttgatgaa tgtcaatcgg gacaatgaag cgctcaacag 383641 cgaagccgtc aaacacggcc tcaagcaaaa aacacatgcc ttttactcat actacgtcaa 383701 cctgatcagc acaggccagg tgaaagcaga tattgatctg ttgacttccg gcgctgattt 383761 tgacatgccg gaatggcttg catcatggga agaagctaca acaggtgttt accgtgtgaa 383821 aagaggcttc ggaacacacg cagaaatgct gcagggcgaa acgctagata ggaatgcgga 383881 gattttgctc gaatttctta atacacaaac cgtaacggtt tcataaatga agtgatgaaa 383941 ggaggagaca gccaatgagc caactcttca aatcatttga tgcgtcggaa aaaacacagc 384001 tcatctgttt tccgtttgcc ggcggctatt cggcgtcgtt tcgccctctc catgcttttt 384061 tgcaggggga gtgcgagatg ctcgctgccg agccgccggg acacggcacg aatcaaacgt 384121 cagccattga ggatctcgaa gagctgacgg atttgtacaa gcaagaactg aaccttcgcc 384181 ctgatcggcc gtttgtgctg ttcggacaca gtatgggcgg aatgatcacc ttcaggctgg 384241 cgcaaaagct tgagcgtgaa ggcatctttc cgcaggcggt tatcatttct gcaatccagc 384301 cgcctcatat tcagcggaag aaagtgtccc acctgcctga tgatcagttt ctcgatcata 384361 ttatccaatt aggcggaatg cccgcagagc ttgttgaaaa taaggaggtc atgtcctttt 384421 tcctgccttc tttccgatca gattaccggg ctcttgaaca atttgagctt tacgatctgg 384481 cccagatcca gtcgcctgtt catgtcttta acgggcttga tgataaaaaa tgcatacgag 384541 atgcggaagg gtggaagaag tgggcaaaag acatcacatt ccatcaattt gacggcgggc 384601 acatgttcct gctgtcacaa acggaagaag tcgcagaacg gatttttgcg atcttgaatc 384661 agcatccgat cattcaaccg tgatcaaaag cggacagctt cggctgttcc gctttttttg 384721 tgttgaatgc caatttctgc atggtataat agtcgaaata ctcaaataaa ggcaggtcga 384781 aacatgcgca cgtctcccag gatgaaatgg tttgtattgc tgtttacgtt tgttttcgcc 384841 atcggaatga actcattcag aaattccttt caatttttta tgctgccaat ggcagacgcc 384901 ttccatgccg acaggtcgct gatttcggtt tctgtcagca tttttatgat cacaaccggc 384961 atcgtccagt tttttgtcgg tttttttatc gaccgtttca gtgtcagaaa aattatggcg 385021 ctgggagctg tttgcatcag cgcaagcttt ttggtgcttc cttattcacc gaatgttcat 385081 gtgttttccg ccatttacgg tgtgcttggc ggaatcgggt attcctgcgc ggtcggcgtg 385141 acgacccagt atttcatcag ctgttggttt gacacacaca aaggtctggc gcttgctatt 385201 ttgaccaatg ccaactctgc gggcctgctg cttctctcgc ccatttgggc tgcggctccg 385261 tatcatgccg gctggcagag cacctatacc attttgggaa tcgtcatggc ggctgttctg 385321 ctgccgctcc tcgtctttgg gatgaagcac ccgccacatg cgcaagcgga aactgtgaaa 385381 aaatcttatg attggcgagg gttttggaac gtgatgaagc aatcccgcct cattcatatc 385441 ctgtacttcg gcgtgtttac ttgcggattt acaatgggaa ttattgatgc tcacctcgtc 385501 ccgatactga aggatgcgca tgtctctcat gtcaacggaa tgatggccgc gttcggggca 385561 tttatcatca ttggcggatt attggcgggc tggctgtcag atctcctcgg cagcagaagc 385621 gtcatgctat ccatcttatt tttcattcgg ctgctcagcc tcatttgcct gctcattccc 385681 attctcggaa ttcatcacag cgacctttgg tacttcgggt ttatcctgtt attcgggctc 385741 agttacacag gcgtgatccc gctgaccgcg gcgtcaattt cggaaagcta tcaaacagga 385801 ttgatcggat cgctgttagg catcaatttc tttatccatc aggttgccgg agctctcagc 385861 gtgtatgcgg gcggtttgtt ttttgacatg actcatggtt atttactgat tgtcgctgtg 385921 tgcatcgtgt ttgtgggttt atcggctgta atagagctgg tgccgttttt agataaacag 385981 aaggcaaaag aaacccacca ttcaatataa aaggatcagc actgtcaatg ctgatccttt 386041 ttaaatttga gtttttttgt ttcggtattt ttaaggataa tctccttgaa tctgttcatc 386101 tcctcttcgg agtgaaaaaa atgtttgggg atcgcaatat attggccact tgatgtattg 386161 accctgaaga tatttttata ttcgaaaaca gctgtaattt catcccaatt gaaaatgagg 386221 tcatattttt tagaacatat acgaattcct tcttggttca gagtatatgt tcttttggat 386281 ttcatccgtt cgttcttctt gtatgctctg gaaaacttca catatagaag aaggaggagc 386341 agcagtgtaa acagaacgga catcacgata atcaacatac tgttcataaa caagttaagc 386401 gcgtcacttc cataaacgat acggggccat ccgttaatga agttaactgc agcaaatatg 386461 gcgcaaaaca atagaaagta aaagcatgat atttttgcga tttgataaaa aaagatttct 386521 cttacatcct taaaagtgat ttctcctgga agattgatac tttcactagc atattgaatc 386581 atacggtaaa cctacacctc taaccatgtt tttcctttta gtctagcata atttctcatt 386641 tttttgcagg cataccaggg cgctttgttt ttttctccag attgatattg ctccccacca 386701 cgccaatcat aatacaaaca gccccggcaa gatgatacca ggccaggctt tcgttgagaa 386761 tcacaaatcc tgcaatcatc gtcacaatgg tagatacatg attaaaagcg ctcattttaa 386821 acgcctcaat tcgcgacagc gtatagttag acagaaatga agtgacaagt gaagacagca 386881 cgcccaaata cacaatggcg agaacgaagc cgggctcccg gaacggcaga aaataagtgc 386941 cgactgttcc cgccgctccg tgacgcacaa gggcgatggc gttgaagacg acaaagccga 387001 tggctgacat gatgtaggtg agctcggtca gcttgaaccg ctgcgtcatt tttctggcag 387061 cagtattgta catcgctgaa gacaaagcgg acaataggat cagcaaagac ccttttaagc 387121 tggctgattc cacgtcaacg cctttcatca caaaaataaa catgacgccg gcaacggata 387181 aaaccgtgaa ccccttttgc gtccacgttg ggcgttcctt taaaacataa gcggcaaaga 387241 ccatcgtgaa aatcggaatg gctgcctgaa taattcccgc ttcagaggag gacgagtaca 387301 caaggccgaa tgcctgaaag ctgaaaaata acgcgggata cagcagggcg agcggcaaaa 387361 tgtcaatgac gtcctttacg cggattgata gctttaccca gccgaataag atcggtacag 387421 tggccgcagc aaacgcaatg gtgaaccgat gcgccaaaat atcaaacggc tctgctgttt 387481 gcagtgcgat ttttacgaat agaaaggata aaccgataat gaacgaatat aaaatagccg 387541 ctatataagc gggggtttgc tgatgtttaa ccataatggg aagggctcct ttacctgaat 387601 tgcagcgccg gtcgctccct ttattgtatg gccgcggtca gaacggtaca atgagaaaaa 387661 caatgaactg taccggtaca aaacaggggg agaaggcatg gagaaatata tgagtctatt 387721 aacgaggata gaggagatga tgcaaagcac ctcatatcaa gaaggagaca ggcttccatc 387781 tatccgtcag ctgtccgccc gctaccaagt cagcaaaagc acagtgatcc gcgcgctgca 387841 ggagctggaa aagcgccacc ttatctattc tgttccgaaa agcggctatt atattgtgaa 387901 aaagtcaggg aaatcaaaaa gcgggcagcc tggccccatc gactttgcca catctgcgcc 387961 ggatcccgat gtgtttccgt atcttgattt tcagcactgc atcaacaaag cgattgatac 388021 atacaaaaac gatttgttta tttatgggac gccaaagggg cttccatcac tcatccgcgt 388081 actccgaaag ctcttggcca ctcaacaggt atttgcggat gaacggcata ttttcattac 388141 atcaggtgtc cagcaggcgt tatccttgct ttgtgccatg ccgttcccaa atgggaaaga 388201 gaagatcgcc attgaacagc cgggctacca tttgatggtc gaacagcttg agacacttgg 388261 gattcccgcc atcggggtga aacgaacgga agaagggctt gatatagcca aggttgagcg 388321 gttatttcaa acagaatcga ttaaattttt ttatacgatg ccgcgcttcc ataacccgct 388381 tgggtgctca ttgtcagagc gtgataaaca ggagcttgtg agactggcag aagcgtatga 388441 tgtctatctc gttgaggatg attacctcgg tgatctggag gaaaataaaa aggcagatcc 388501 gctgtacgca tatgatctgt cctcacatgt catctatttg aaaagcttct cgaaaatgat 388561 gttccccggc ctccgcgtgg gggcggctgt tttgcccgaa gcgctgactg acacgttcta 388621 tgcgtacaaa aagctgaacg acatcgactg ttcgatgatt tctcaagcgg cattggagat 388681 ttacctgaaa agcggtatgt acggcaggca taaggagaaa atcagagatt cttataaaga 388741 gcggtcgctg aggctacatc aagccattcg aactcacagg cagctgggaa gcggacgctt 388801 tacgttctcc agcgggcagg caccctgtat gcacacccat ctggtgcttc ctcaggatct 388861 gcccgcctca agagtgattc atagactgga aaaacaaggg gttctccttg aggcgataga 388921 ccgtcattat ttatcagatt atccgaaaga aaatctatta aaaatcaata tttccaatgt 388981 gaaaacggaa gatattgagc gcggtgtcaa gctgttgatg agccatttat aaaagctctt 389041 cgtacgagac cattgtgata tcctcgggga aatcagggtg tacggcgcat acagccattt 389101 tgtagccggg atcgacctca tacgttttga tatagcatgg ggaatggctg tccggaagct 389161 caatggatac ttgtccgtcc tggtgcaggc gcactgaaaa ggaatcaagc ggaagcgata 389221 agcctttgcc ttccttgttt gataaagctt tctttcattg accatagatg ataaaaatag 389281 tctgtctgct cgtccttgtc ttttgctaaa aggtcgctgt actctgtttt tgaaaagaag 389341 cgcttggcga tctcaaggct gatcggtttc gttttttcga tatctatgcc gatcggctgt 389401 gaatcaaacg cgcaaatgac ccagcgtccg gagtgagaaa tgttgaaatg agcgtcggga 389461 agatcaggga tgcacggctt cccgtattcc tgcgtgctaa agcggatatc ggatttgtcc 389521 aactgatact gcctgcttat gactgagcga acgagcacat ctcccagcag ggtgcggtga 389581 gcatcttctt tatgataaaa tctccggcat ttctcccgtt tttcaggtga tatgaaagac 389641 atgaaccgtt cattttcttc ctgtgaaagc gggcggtcca tataaattcc gtaaatcttc 389701 attctagatc ctccgtctgc aaaagattgt caaaaccatc ctatcatact tccacaagac 389761 tcatatagag gagaaaataa aaaaacaaag ccaaggcggc tttgttttag tgtacaggcg 389821 gagatgcttt cactgcggct gtccgccttg ccacagcata attcagcaac tggattgact 389881 ggggcaatga aaaacgcaaa ataagtccgg tgaggatggc ggtcaaaatg gtgccaaaac 389941 cgatcggtcc gcccatgccc catgccgcaa acaaaatggt taattccatg ccgttccgca 390001 cccattgcac attccagccg gttttttctg taatcagcat catcagtgaa tcacgcggcc 390061 ccgcgccaag gcctgctgat acataaacac cgacgccgta accaatcagc accacgccta 390121 gagagaagac gatgatcgag cctgtgtagg tcgagagggc aggcagaatg aaattgaaaa 390181 aatctataaa tacaccaatg agcaccatat tcaggagggc accaattttc ggccaagctc 390241 tcgtaaacaa tgacgtgaat ccgacgatga gcgctccaat aatgatggac cactggccga 390301 cggtaagccc gaagtgctga aacaggctgt aatgaaatgc atcccacgga ctaatgccga 390361 gtgcttttcc ttctatcgtc agggatacac caaaagccaa aatgatcaaa ccggcaaaat 390421 aaaatgtcca gcgcagaaca agttcttgct tcacgtgagg tcccttcttt cgtaaaaatc 390481 agtcgattgt cattgtagca catctgacag aagggcggaa taggcgaaag gggctcaaca 390541 aaaaaacagg gccgccggag gcgccctgtt tcagcgtgtt ggcaaaccct tgcattcgtt 390601 gtcaggcctg tgcttcggtg ctcacgaatt taacattagc tgtgctccaa tgctcgccct 390661 tcctagactt caaaggtttt caatcacgct gaaaatcaca aaatcctaaa acgaatatcg 390721 ttttaggatt ttgtcaataa tctgaaacag ggcgctgacg ctctgttttt cttattacag 390781 cgggttcaaa atccggttta agaaccgctg tgtccgttct tcttttggtg cggagaaaat 390841 ttgctccggc ggtccctgct ccacgataac gccgccgtcg atgaagatga cttcatccgc 390901 aacctcctgc gcgaacttga tttcgtgggt cacgacgacc atggtccagc cttcattggc 390961 caagtccttg ataaccttca gcacctctcc gacaagctcg ggatcaagcg ctgaggtcgg 391021 ttcgtcaaac agcatgagct caggctgtat cgccagtgcg cgggcgatgc cgacgcgctg 391081 ctgctggccg ccggaaagct ggaacggata taaatccatt ttgtccttca atccgacttt 391141 atcaagaagc tgaatcgctt cttttctgac ttcctctttg ttccgttttt gcacctgaac 391201 agggccctcc atcacgtttt cgagggctgt gcggtgcggg aacaggtgat acgcctgaaa 391261 caccattccg gattttcggc gaagctttag gatatccgcc tgtttcacct ttttggagaa 391321 atcgatggag aaatcatcaa atgcaagctc tccgcgattc gggatctcca gagcgttcag 391381 gcagcggagc agcgtcgttt tccctgaacc tgaaggccca agtatggcga tgacttttcc 391441 tttttcaatc ttcatatcta tcttttttaa aatttcattt tcaccgaatg atttgtttaa 391501 tcctttaacg gtaagcatac tcggaacctc cttatttggc cacgtagcgg tcaagacgcc 391561 gttcgatgac atgctggacg agtgagagca ggaagcagat aatccaataa ataaaggctg 391621 cttcaatata gatcactaaa atttgatcaa gattccgcgc gccgatttcc tgggcttttc 391681 tgaacagctc agcgaccaga atttgagagg cgagggatgt atctttaatc aggctgataa 391741 aggtattgga taatggcggg atcgacacac gaaacgcctg cggcaaaatg acgcggaaca 391801 gcgttttttg atgtgtcatg ccaattgtgt agccggcttc ccattgccct ttcggcacgg 391861 ataaaataga tgcccgaatg atttcagatg cataggcgcc gacgtttaat gaaaaggcga 391921 taactgcgct tggaaatgga tctaatgtga cgttaaaggc cgggaacaga tagaaaatga 391981 tgaacaattg aacgagaaga ggagtgccgc gtattgcgga tacgtatacg ctgaacaccc 392041 atctcaaagg tctcactttc gacattctgg caagcgccgt aatcagcgcc aggatcattc 392101 cgaatataaa ggaaagaatc gtaaggggaa tcgtatagta gattccccct gaaagtatcg 392161 gccagaatga ctgctgcacc agatcccacg ggatcgccgt gccaagcgtc aatgccggca 392221 gattatttag aaacatcttc gccgaaccat tttttagaaa ttttagaaag agtcccgtcc 392281 tctttcattt cttttaatgc tttgttgact tgatcaacaa cctcgccgct tcctttacgg 392341 aacgtgaaat atgttgactg aggctcacct gtttcaaacg cgattttcac gtttttattg 392401 ccagatgttt ttaagtagtt caatacggca agcttatcgt tgtatgtcat atcgacgcgg 392461 ccttgctgga tcatttgaag ggcctgcgcc atgccttcaa cgccttctac tttagcgccg 392521 gcatttgtag ctaatttgtt gtagttgctt gtcagtgatt gagctgacgt ttttcctttt 392581 acatctgctt cagacttaat atcgttgttg tcttttttcg ttacgacaac ggctcttgat 392641 gttgtgtatt tatctgagaa atcatatttg tcttcacgat ctgtttttcc gacttggttg 392701 gcaacaacgt caaaccgttt ggaattcagg ccggcaaaca tactgtccca ttgtgtttcc 392761 ttaaagtcga ctttaagccc gaggcgtttt gcgacttctg tgataacttc gacatcatag 392821 ccagtcagtt tatcagtgtc tttgtcgtgg taagtgaacg gctcatatgt tccttccgtt 392881 ccgactgtga gcacaccttt tttcttaatt gaagcccaaa gatcgccatc tttggcatta 392941 tcttttgact gattgtcatt tcctgctccg caagctgcaa gagctgcaat acttacgacc 393001 atgaataaag ccaataatgc ttttttcatc ttattcccca cttttctggt tgattttatt 393061 gaaataaaaa attagcttac aaatctaaag gataactttt ttttagtatg agtcaagtat 393121 ttggttttca taagacaaaa tcttttaaaa taaatccaaa aattgctgtg ccggtttagg 393181 caaataactg tccgttctcc acatgacagc cggtgtcata atgaagggat tattttcgat 393241 atggacggtg tgaacgtgat ttctcatatg aacgggaatc attgtgacag gcaaaataga 393301 cgcgccgaat ccggatgaca cgaggctgag caaagttgca gagtcgtggc attcacaaac 393361 aatgcgcggc tccaggttca aacgatgaaa ttcattcatg acctgattat agacgccttt 393421 tccgttgaca ggccgcagca ggatcagcgg aaatgaagga atgtccacca tcttaatggt 393481 gtctccgcac ggatatccgg cttcatctga aagcacgagc acacatggaa tgtcatcaag 393541 ctgcttgaat tgtactgtgt cacttttgat cagtgttgtc gtgaccgccg catcgatttg 393601 ccggctttcc agcagttcca acagtgtcgc gggttcattt tcccaaatat taaaggtgag 393661 atgggggtat ctctctttga tctgtgttac tttttcaagc atcagagccg cgcaataaat 393721 cgttgatccc acggcaagtg taccggctac ttcctccttc agctcctgta cctcaatgac 393781 tgcatcttca aacctatgca gaatctcttt tgctcttttt agaaaaacag ctccttcata 393841 tgtaagagtc atttgttttt tcttgttacg gtcaaacaga acaacaccaa gttcgtcctc 393901 cagctgtttg agctgcctgc ttaaaggcgg ctgcgccatg tgaagctttt tggctgcgga 393961 cgtaattttc tgttcttggg caatggtaat gaagtatcga agctggcgaa tatccaaaag 394021 aaagcgcctc cttatcatac cttttaggta ttaattatag atttaataga tatttttcat 394081 atggatatat caggagtatg attgaaatga aagcagaatt caagcgtaaa ggagggggca 394141 aagtgaaact cgttgtcgga atgacagggg caacaggggc cattttcggg gtcaggctgc 394201 tgcagtggct gaaggccgcc ggagtggaaa cccatctcgt tgtgtctcct tgggcaaacg 394261 tcacgatcaa acacgaaaca ggctatacgt tacaagaagt agaacaactg gccacataca 394321 cttactcaca taaggatcag gcggcagcca tttcaagcgg gtcgtttgat accgatggaa 394381 tgattgttgc gccgtgcagc atgaaatctc tcgcaagcat tcgcacagga atggcggata 394441 atctgctgac acgtgcggcg gatgtcatgc tcaaggagag aaaaaaactc gtcctcttaa 394501 cgagagagac gcctttgaac caaattcatc tcgaaaatat gctagcgctt acgaaaatgg 394561 gcaccatcat tcttcctccg atgccggcat tttataatcg gccgagaagc ttagaggaaa 394621 tggttgacca tattgttttt agaacgttgg accaattcgg cattcggctt cctgaagcga 394681 agcgctggaa tgggattgaa aaacaaaaag gaggagcttg atcatggctt atcaagattt 394741 cagagaattt ctcgctgccc ttgaaaaaga aggacagctg cttacagtga atgaagaggt 394801 aaagccggaa ccggatttag gggcctccgc acgggcagcc agcaatcttg gcgataaaag 394861 ccctgcgctc ttatttaaca acatttacgg ctatcataac gcgcgaattg cgatgaatgt 394921 catcggctct tggccaaacc atgccatgat gctgggcatg ccgaaagaca caccggtaaa 394981 agaacagttt tttgaattcg caaagcgtta tgaccagttt ccgatgccgg tcaaacgtga 395041 ggaaacagcg ccatttcatg aaaatgaaat cacagaagat atcaatttgt tcgatatact 395101 gcctcttttc agaattaacc agggtgatgg aggctactat ttagacaaag catgtgtcat 395161 ttcccgtgat cttgaggacc ctgacaactt cggcaaacaa aatgtcggca tttacagaat 395221 gcaagtcaaa ggaaaagacc gccttggcat tcagcctgtc ccgcagcacg atattgcaat 395281 ccatctgcgc caagctgaag aacgcggcat caaccttccg gtcactattg cgctcggctg 395341 tgagccggtc attacaacgg cggcatcgac tccgcttctc tatgatcaat cagaatacga 395401 aatggcaggt gcgattcaag gcgaaccata tcgcatcgtc aaatcaaagc tgtctgatct 395461 tgatgttccg tggggcgctg aagtggtgct tgaaggtgag attattgccg gagagcgcga 395521 atatgaaggg ccgttcggtg aattcacagg ccattattcc ggcggacgca gcatgccgat 395581 tatcaaaatt aaacgcgtct atcacagaaa caatccgatc tttgaacatt tatacttagg 395641 catgccttgg acagaatgcg attacatgat cggcattaac acatgcgtgc cgctttatca 395701 gcagttaaaa gaagcgtatc cgaacgaaat tgtggcagtg aacgccatgt acacacacgg 395761 tttaatcgcg attgtttcca caaaaacccg ctatggcgga tttgcgaaag cggtcggcat 395821 gcgcgcactc acaacgccgc acggactcgg ctactgcaaa atggtcatag tcgttgatga 395881 ggatgtcgat ccattcaacc ttccgcaggt catgtgggcg ctttcgacca aaatgcatcc 395941 gaaacatgat gcggtcatca ttccggactt atctgtcctg ccgcttgatc cgggatccaa 396001 tccatcagga atcactcaca aaatgattct cgacgccact acaccggttg cgccggaaac 396061 aagaggccat tattcacagc cgcttgattc tccgctaaca acgaaagaat gggaacaaaa 396121 actaatggac ttaatgaata aataaggaaa ggatgttcga aatgcataca tgtcctcgat 396181 gcgactcaaa aaagggagaa gtcatgagca aatcgcctgt agaaggcgca tgggaagttt 396241 atcagtgcca aacatgcttt tttacatgga gatcctgtga accggaaagc attacaaatc 396301 ccgaaaaata caatccagcg tttaaaattg atccaaagga aacagaaaca gcaattgaag 396361 ttccggcggt gccggaacga aaggcttgat ccgcgtgaac tgtatgtcag accgtctctt 396421 tgagctgctt gacgggagct gcctgaatga gaagcagcat gaggccttcg ttctgcaaac 396481 agtatcagag gatggctggc cgcatgccgc tatgatcagt gcaggtgaaa tcatcgcgct 396541 gagccgaact gatatccgaa tcgctctgtg gaaaaacaca atgacttcgg ccaacatcct 396601 tcgcacagga aaagcacagt tcacggcgtg gtggaaggga gcggcctatt atgtaaagct 396661 tgaatgcgcg cctttaccgc ctttgaaaga tgccgaatat gaaagagacc gtttttcctg 396721 ccgcatcgtt tcagtgaaag aggacgttgc gaaatacgct gatttgactt caggtgtccg 396781 tatacagctt cacagccctg aagaggtgct gagcagatgg aaaaagaccc tggaagattt 396841 aaaacggtaa tatcgatagc ctgacgccat gcgtcaggct ttttttatat aatgaaaaca 396901 aaagggggcg tgagaaatgg aacgtgcggg gatctgtcac tcggacggct ttgatttagc 396961 ttatcgaatt gagggcgagg gcgcacccat ccttgtgatc gggagtgcgg tttactatcc 397021 gcgccttttt tcctcagata tcaaacagaa atatcaatgg gtctttgtcg accatagggg 397081 atttgctaag cctaagcggg agcttcgtgc ggaggattcg aggcttgatg ctgtcttggc 397141 tgatatcgaa aggatgagaa catttcttca gcttgaggat gttactatcc tgggacattc 397201 cgggcacgct tttatggctt tagagtatgc caggacatat cccaaacaag ttcggaaggt 397261 ggcgctcttt aatactgcgc ctgataacag tgaagaaaga cagcgaaaaa gcgaatcatt 397321 tttcatggaa acagccagtc ttgagagaaa gaaacgcttt gaaaaagaca tcgagaattt 397381 gccgcaggac atcgacaaag atcctgaaag gcgctttgtg cacatgtgta ttcgcgctga 397441 agcgaaaagc ttttatcaag agcggccgca tgctgctgcc ttatgggacg gtgtattcac 397501 gaatatgccg atcattgatg aattatgggg caatacattt gcccggattg atcttcttca 397561 gcggttagct gatgttcgta tgccggtgta tatcggatta gggagatatg attatttggt 397621 tgcgcccgtt tcgctatggg atgctgttga cggtttatat ccccatgttg ataaggttat 397681 ttttgaaaag agcggccatc agccgatgct ggaagaaccg gaagcctttg atcaaagctt 397741 caggaaatgg cttgatcaat aaaaaacagc ccgcagatca acatccgcgg gctgtttctg 397801 attataagac ccctttcatc gcgcgtttga tcaccggcga gagcagcagg agaatgccgc 397861 caagaacgat agaaatcaaa ccgatggtgc cgaagtacat tgtttcagga attttatcaa 397921 acaatccggc tacttgggca ttgatcgctt gggctgctgc gttcgtcaga aaccacatac 397981 tcattgtctg tgcagagaag gcagctggtg ccagtttcgt tgtcacggat aaaccgactg 398041 gagacaggca cagctctcca agcacgacaa gcaggaagct gagaacgagc caaagcgggc 398101 ttacgagtgc ttcttttcct tgcatagcag ggaataccat aatgataaat gacaatccgg 398161 ctaaaataat tccgattgag aatttaactg gtgtagacgg ctgacgtttg ccaagcttca 398221 tccagagcca tgcgaatatt ggcgcaaaaa tgacaacaaa caatggattt aatgattgga 398281 accatgatga ctgaagttcg aatccgccca atgaaagtct tatgcgttca tcagcgtata 398341 ccgcaagaat ggtcgctccc tgttcctgaa tggcccagaa catgacagca ccgataaaca 398401 aaggaacgta agcggcaaga cgggattttt ctgttttgtc cgcttttttg cttgtaaaca 398461 tgatgatgaa ataaatcaca ggaatcaaaa taccgagaat acttacaagg tcaatgaaac 398521 gtttgatcgt cagcacgcct gtttgtacag agataatcac tgcgatcgcc acaatgataa 398581 caccgattcc ggtgccaatt gcagattttt tagacagcgg attcggcaca ttggaacctg 398641 caagcccgag gtttttcttt cttgtcaaag caaatacgat aagtccgaga agcattccga 398701 ccgcggcagc tccgaatccg agatgatagt tgtacttctg tccgagtgtt ccgacaatta 398761 acggcgcgag taaaccaccg aggttaatcc ccatgtagaa aatactgaaa cctgagtcgc 398821 ggcgcgggtc ttctttcgtg taaagatccc caactacgct tgaaacgttt ggttttaata 398881 agcctgttcc gacaatgata agcaccatac tgatatagaa tgctatcgaa ctgcccggat 398941 aggcgagtgc aatgtggccg aacataatga atatgccgcc gtaaaacacg gtgtttgcgg 399001 taccgaatac ccggtcagcg agccatccgc caataatggt ggacatgtat acgagtgatc 399061 cgtaaatcga cataatggca accgcagtgc ccttgtcaaa gccgagccct ccgtttaccg 399121 tctctgtata caaatagtaa agtaagattg ctctcattcc atagtaagag aaacgctccc 399181 aaaattcggt gaaaaatagt gtaaatagtc ctcgcgggtg accaaagaac cctttttgcg 399241 ggacgctttt aatgatactt tcgttatcaa tcgaagccat gtcagccaaa ccctttctaa 399301 aaaaagtgta ttataaaaat catattctta tataatactt gtgtcaatat aatttatact 399361 catttcaaat agttccatat tggaaaaatt ataaatacct aaaaatagtg atttcctcct 399421 aatttttaaa ctttttatcg tgagattttc ttacacaact attcctttat atttttttaa 399481 taaaatttta gagaaatgta caagcagatc gggcctttgt gagtaacatg atagtaatca 399541 tagagaagga ggctcgcaat tggctgaatt catattaaat gcagcggatt tcggtgttcc 399601 tagagatggt aaaacggatt cgacagaacg gattaatcag tgcctcagta cagctgtttc 399661 gaaaggctat catactgtct ggtttccaaa gggaacatat ttaatagacg caacgcttgg 399721 cggagatctt aatcagaggt ttcgaaacgc ggggatcatt gttcccggca accttgagat 399781 tatgatggac cccgaatgta tcatgaaagt gataccgaat agttcgtggg gttattccgc 399841 attttatgta ggcaagcaag agaatataac tatttccgga ggacaaatta tcggcgaacg 399901 ggatgagcat acgtatgcct cggcggggat aaggtcaacc catgaatggg gctttggcat 399961 atgtattgaa ggatgctcga atgttgtcat tgatgatgtg aaaatttccg attttaccgg 400021 cgatgggatc atagtcagcc caaggggatt aaagaccaat caagattatc gaacgtcaga 400081 gcaaattatc atccgccgct gtgaggttcg gcggtcgagg agaaataaca tttccattac 400141 cggatgtgac atggtcacgg tggaggaatg cttgattgaa gatgccggaa cggggaatgg 400201 aacagcgccg aaattcggaa ttgacattga aggatatggc gaaggtgacg ttgattatga 400261 ggaaccgatt aatgtatcaa ttcgcaataa ccactttgtt ggaaacgttt caagttctgt 400321 gaccaatttt aacgggtatg gcattttaat agaaggaaat cactcagaca atacaatcag 400381 ctacggatat gggacgcaaa cagtgatcaa gggcaatatt ctgagacgcc ctgaagacgc 400441 ggcggctgcg ccaagagtcg ggataaccgg actcggtgta tcacaaggaa aagagaccag 400501 tgatgcagtg atcgctggca acctcattac cggattttca actggaattg atgtcagggg 400561 aaagagcgtt cttgtgacga acaacaaaat cagcaacttt gaaaacacag ggatattggt 400621 ttatcagtcc tccgacgtaa aggtagacgg aaaccaaatt caaaacggac tgtctgaaac 400681 aaggcgcagc atcggtcttc gcgcagtgct gtcagatgac atcgcatttc tgaataactg 400741 tctcattcaa gtcgttgacg gtgtgaacgt ttccggcgga aatatgatca ttaaagataa 400801 tctcctgaga aaattcagcc ggggcatttg gattgctcaa gggaacgcgg tgattgaagg 400861 gaatacactg aatcctgacg cgtttgaagc agtgccggaa tcatattctg tttccgtcac 400921 aaacaatgcc ggcgccatca tcaaaaacaa tacatttaaa gagttcaaaa attaccccat 400981 ttattgctcc acaagtgcaa aaacctcaat tatcggcaac cacttagagc gatccccgct 401041 tttggtcacc atctatatca gcgcaggtgt gcatgagatt tttgataata ccatttcagt 401101 caacagaaca gccgggaatc cgattgtgat ttatctcaat ggctctgcag gctctatcat 401161 ctctggaaac accatcaata acctctccgc gggcactgcg acagctattc aaacaaacac 401221 gtcaaccaat tccaaaatca tcggcaaccg catttttaaa gggaccatca acaaacacag 401281 cagtgataca atagacggca atatgattgt ctgaaaaaag cgcccccctt taggggttct 401341 tttttttcga tttatagatc acgtacattt ctctcacaag tactaacaca aaaaataaaa 401401 gcacgaccca ttccgcaaat gttgtcatct taaagctgga catattgtta taaacggctt 401461 ttgttaaact gaacccttga agcatgtcca tcaacacaga aatagctaat aaacaaatta 401521 atatgaatcc ggtcacgccc aatatcttca tgcttcatca tcctccgctt ttagtgtcta 401581 tctttggcgg agaagttata ccgcatctaa ccctaatgca taatctcaat tttaaaagga 401641 agaatatgag aaaacgacaa ggaaaggtat ttgtgtatgc ctttattttc taagcgaaag 401701 aacaataccg attcaaaaga caagcagaat acagacgaaa ggaatcagga acagcagcaa 401761 gaaaaagaaa ggccggttct catttctcca agtttagcaa agaatatagc ggaaacgaaa 401821 aaggaagtcg gaagcagctc tgacgtcatc attcgcgaga ttaaaatcgg ggagcaggat 401881 catgtccacc tagctgttat ctatatttct gggctggtcg ataataacac gatccatgag 401941 tcgttaattg acccattggt acaggatgag tctatccaga atactcatgc gatccagcaa 402001 attcttgaaa aaacgctccc gctgggcggg gtgaaagcgg aaaagagctg ggacaagctt 402061 ttttccgagt taatgcttgg caatgcgctc atttttgctg atggccatga tgaagctttg 402121 atttgcagca ctcaaggggg agagcagcgc tccatccaag agccgagcac ccaggtgtca 402181 ttccgcggcc cgcgccaagg gtttacagag tctctgcaaa ccaatatttc catgatccgg 402241 cgatacatta aaaatccgaa tttatgggtt gaaaaaatga aaaaaggttc tgttacgaat 402301 acggatatcg ctctcatgta cattcaagga atatgtgatg aaaaggtgct gaaggaagtg 402361 aaacagcgcc tggaaaaaat agatattgac agtattttgg aatctggata tattgagcag 402421 ctgattgaag atgaaacctt tacgacgttt ccgactatgt atcatacaga acgccctgat 402481 gttgtagcgg gtaatctgtt agaaggaaga ttcgcgatta ttgtggacgg aacaccgttt 402541 gtgcttattg ccccagcctt atttgtccag ttttttcagt ctgttgagga ttattattcg 402601 cgttttgaca ttgcgacaag cataagaatt cttcgtgttt tagtcttttt catttcgctt 402661 gtggcaccag ctgtatacgt ggcagccacg acgtttcatc aagaaatgat accgactcag 402721 ctgttagtgg tcattgcggc ccagcgggaa attgtcccgt ttccggctgt tgtggaggcg 402781 ctgacgatgg aggttgcttt tgagattctg agggaagcgg gagtcaggct gccccgggtt 402841 gtcggctcgg cagtgtcaat cgtaggcgcg ctcgtaatcg gccaggctgc cgtacaggct 402901 ggtatcgtct ctccggcaat ggtgattatc gtggcactca ccgcgattgc gagcttcgca 402961 acaccggcgt ttgcaatggc gatttcagcc cggcttattc ggtttatctt tattattgcc 403021 tcagctgtta tgggttttta cgggctgatt ttagggatca ttatgatgtt tgtccactta 403081 tgcagtcttc gttcattcgg cgttccatat atgtcgccgc ttgcaccttt ttcttcacaa 403141 ggcgtaaagg acgcgctttt ccgggttccg tggtgggccg atgaaaaaag gccggaatcg 403201 gtcagcaagg aagataaggt gcggcagggg aaagatcaac gcccagagcc ggccgcttca 403261 cgaggaatgg tgaacaaaga tttggaagaa ggggatcaga atggtacgta aatgtctatt 403321 agccgttctc atgcttttga gcgtcattgt gctgcccggc tgctgggata agcgggagct 403381 gacggatctt gcgattatct cggcgattgg catcgatcgg acaaacgaca gcaactacgt 403441 gctgcatctt caaattatca atccaggaaa tgttgccggc ggccttcagg gaggcggtgc 403501 tggagacagg ccgcctgtat ctgtctattc gattgaaggt aacaatataa cggaagcact 403561 cagaaaagcc tccatgaagg tatcacggcg gctttatttt gcccatacca atctagtcgt 403621 gatcaatgaa aagctggcaa aagaagaagg tttggatttt gtattagata atcttgaccg 403681 ggacacagaa ttcaggacaa cagcaacatt cgtcgttgcc cataaaacaa aagcagaaaa 403741 tattgtgaaa atcttgacgc cgattgataa aattccgtca aataaagtca ataaaacact 403801 cgatttcacg gaggcacaat acgggcgggt ggtcaaaatc aatattcagg acgttttgaa 403861 aacacttgcc gccaacacta tggcaccggt catccccgga tatatgatga ttggtgacga 403921 taaaaaagga gtcagcatgg aaaacacgca ggcgactgac ccgaaagcca ttcttcaggc 403981 agatggtttg gcggtttttg ataaggcagg atatttaaag tattggctgg aagatgatga 404041 aagcgtgggg gcagtctggc ttatgaataa gatccagcat acgtttatta atgctgactg 404101 gggcaagacg aaggatgcgg tcagcttgca ggttacccat caagatacaa agctggtacc 404161 gaaaatgcgg aacggacgcc cgtacatcca tgtgaaagtg tcggttgaag gtattataga 404221 tgctgtcaaa taccctttcc aattgtctga tcccaaggtg ctggccgcta ttgaaaaagc 404281 gctcaacaaa gagcttgaaa aggaaatcag ccatactgtg aaaaagatta agaagaataa 404341 aatagatttt atcggttttg gtgacacgat atatagaaag tatccggagc agtgggagaa 404401 aatgaaggac acttgggaca aagaatattt gccggaactg cccatcgatg tgaaggccga 404461 gacgtatatc agaaggacgg gattgcgaaa caatccgatc aaacaccagt ttaaagatga 404521 ttaggtctga agaaagggga agtgacagat ggaaaaagcc agaataagca taaggcagtt 404581 gtttgtcatg attatcattt ttgaactggg cagctcctta ttgattacac cgggatcaat 404641 ggcgggcagg gatgcttgga tagcagtttt attaggctgt gcgatcggac tgtttctttt 404701 ctatttgtat caaggcattt atcaatgtta tccgaattct tctccgaaag aatatatgga 404761 tgatatgctg ggaaccaagc tgagctggct gttttcattt ctctatatct tgtactttgc 404821 ctatattgcc gcaagggtgc tgcgtgactt tggagaaatg ctgctgacgt ttgcttatca 404881 tgatacacct atcattattg taaatgcttt attaatggta gtaagcatat atgccgtaag 404941 aaaaggaatt gaagtactcg cacgcgcggc cgaacttctt ttcggggcca tgtatttact 405001 gggcgcgatc ggccttgtgc tgattattgt ctcagggact atagacccgc acaatttaaa 405061 gccggttttg gcaaacggca tttctcctgt ccttcactct gttttcacac agaccatgta 405121 cgttccattt ggtgaagttg ttttatttgt gatgattttc cctaacctga atgacagaaa 405181 agatgtgaaa aaaatgggga tgatcgccat ggctattagc ggattgattg tggcgctcac 405241 cgtggcgatt aatattagcg tgcttgatgt tgatcttaca ctcagatccc agtttccgct 405301 tttaagcacg atccagacaa tcaaggtcga agaattttta gaccggctcg atgtcttttt 405361 tatgctggcg ctgatcatcg gcggcttctt taaggtcagc ctctacttat atgccactgt 405421 ggttgggaca tctacgctct ttaaggaaaa gaacccctct caattggctt atccgatggg 405481 attgggcatc ttaatccttt ctataacgat cgcgactaac ttttcggagc acttgaatga 405541 aggcctgaac gtggtgccgc tgtatattca tttgcctttt caattattgt ttccgctctt 405601 tctgtttatt gtggccgttt ggaaaaagaa acgaagagag aagtcaaaag gggaggaagc 405661 aaaaaaatga taaaaagagc ggggggatgc ggccgccgct ctttttatgt tcacttctat 405721 ataaaagggg gatatagggt gcgcccctgt ctgcactggc agaggcgcgt tttgttatac 405781 gactgcgacg ttttccttca cagtaaaact tcctcttgaa agtctgatat tgatgtctga 405841 cacttttgca atttgttcat cgtgcgtcac cataatgacg catttatctt ccttgtgcgc 405901 cagatcctga aagagccgta cgatctcttt tgatgtgtcc tcatcaaggt ttccggtcgg 405961 ttcatcggct acgataagat ccgtgtcaca gcagaaagcc cttgtaattg atacccgctg 406021 ctgctgtccg ccgctcagtg tgagcacttt ttgccgggct tgtttttcgt tgatgccaac 406081 cttctgcagc atgtcaagcg catatgattc tttgttcttt tctttagaac ctgtgatttc 406141 catagcggtt gtgacgttct gcaaagccgt catatacggg agcaggttgt acgcctgaaa 406201 gacgattgat acatattgat ttctgaaatt ggttaagccg attttagaaa ccgcttttcc 406261 gtcgtaaagg atgtttcctt cttttggtgc gtcaagtccg cctgccagag acaggaaagt 406321 ggttttcccc gtccctgatg ttccgacgat tgtgtagaat tttccttttt gaaagctgat 406381 gttaatatcc tgaaacaatg gctggctttt gtttttatac cagtagccga cttgttgaaa 406441 ttgtaataag ctcataggtt ccgcctcttt ctattcctgt tttgtcaata tcgttttcgg 406501 atgaagccgc agtactgaaa ttgacggcag caatgttgca atgattgcga ttaggatgcc 406561 gatcccgcca agtataagca tgtcgttcat agaaaccgcg acgttcagtg aatcgataac 406621 gtccacgttg gatgaactgt ggccgaacat tttgccgccc atgccgccac cgccgccggg 406681 catttgtccg cttgcggttt gcgttgaatc ggttgatgaa ctgatttgct gggataaaag 406741 ctgatttcca agctgattcg cgacgagatt tcccgtcaca gatgcaaggc cgatagcgat 406801 aacggccaca atcagaatct cagtcaagaa ctgtccaatc aatttccatc gtttttcacc 406861 gatggccatt aacacgccca tttcgtattt gcgctccctg attgacatca tgacaatcag 406921 gccaagaatg acggcgcctg ccactgatac aagatacacc acgtttttag agaaagaagc 406981 cacattttca atcggtccga ccatttgctg gtaaagctga tcgtttgtat tcagtgtgta 407041 cgtatcaaag tcaattgatg ttttcttcgc tgcttttacg aaagtatcca tatttttcgc 407101 gtcgtccata tagtaaacag ctgagtcaat cgtattttta tagtcgtcgc ctttcaatgc 407161 cgctgttgct gtgtaaggcg tataaagctt gttataagga tttaagaaag agaaattttg 407221 ggcttggtca tcacctgaag atgttgtttt ataaataccg acgatcttca gttttactgt 407281 tgtatcctca tccgttgctg attcaattgt gatcgaatcg ccaacgctta aatcattttc 407341 ttccgctaat gtttcgttga tcactgttac ttttttgccg acatctgatt ttgtaatcgc 407401 gcgtccgtct gtgatttttg aatctccgtc agagaaatca tcgactaacg ctgtgctgat 407461 gacaccttca atagaaagat cagcttgaac catttgcggt ccgccttgtc ctccgccttg 407521 actgttttta gcgtttgagc ttgaactgct ggagctggaa tcacttgaac tagagctttc 407581 aatcgcatca aagtttcccg cgttggctga agctgatgtg gtgtaattgt agctcttcac 407641 atgatcaagc gctgcaagct tattcgcatc agacactttg atcggtgtgg attcgaagct 407701 gcgcttttca ccgctgtcct gctgtttttc catttgcttt tggcggtcaa cctgaagtgt 407761 cacgcttcca ccgagttcct gtctggccag ttcgcttgac ttttgtgctg ccgactggat 407821 ggcgaggcct gatagaacaa agacacatat gactgtaaac acaaataatt gcaataacgt 407881 ttttcccttt ttagccttca tattccaaaa ggcccgtttg ataaagttca tttatgttcc 407941 tccgtatagg tatttttatt gataagaccg cctctggggc gcgtcccctt gctgataaat 408001 taatagtagt ccaaaggtat gaaaaaaata tgaacaatct atttctagtt gatgaaataa 408061 aaactaacaa ttgtgaaacg caaaaccttc tgtttaaaat ggtgctatta tataaaaaag 408121 catcaaaaca accggaggat ataatgaaaa tattaatgat agaagataat gttagtgtat 408181 gtacgatgac ggagatgttc ttttttaaag aaggttttga agccgaattc gttcatgacg 408241 ggttagaagg gtaccagcgt tttacggaag aaaattggga tctaatcatt ttggatatca 408301 tgcttccatc tatggacggc gtgaccatct gcagaaaaat aagagagaca agcacggtgc 408361 cgattatcat gctgactgcc aaagacactg aatcagatca ggtcatcggt tttgagatgg 408421 gggcggacga ttatgtcaca aagccgttca gcccgctgac attggttgcc cgcatcaaag 408481 ccgtcatcag aagatataag gcgacaggca aagcggttat tgatgaagat atgattgaaa 408541 cggaatgctt taccattaat aagaagacga gagaagtatt attaaacgga gagcctgtag 408601 aaaatctcac gccgaaggaa ttcgatctgc tttattacct tgtccaaaat ccgcggcagg 408661 tgttctccag agaacagctg cttgagcagg tatggggcta tcaattttat ggagatgagc 408721 gaacggttga cgttcatatc aaacggctgc ggaaaaagct tgccagcgag gacaagcctt 408781 tcctgtatac tgtgtgggga gtagggtata aatttgatga agattaaata tttatatcag 408841 ctgctgctaa gccatatcag cattttgatt ttagcgtttg tcattatcat ttctctgttt 408901 tcccactttg tgaaggaatt tgcctatcag aacaaagtag aggaattgac gtcatatgcg 408961 gtgcagattg caaatgaatt ccaatccggc caggtggaca tgcgcaggct ctatccttat 409021 caggacattt taagcacaag aaagacgcaa tttatcatct ttaatgaaga gcagcagcct 409081 tattttcttc ctgaaggctt tcatcaccca ccaagggaac agctgaagaa atcagaatgg 409141 aataagctga aaaaagggca gactgtcacg atcagggcag atggccgttt tgatgatgaa 409201 gtgtcccttg tggcgcagcc tatatttgtt cagaacgaat ttaaaggcgc cgttctgctg 409261 atttctccga tcagcggtgt tgaacagatg gtcaatcagg tcaacctcta tatgttttac 409321 gctgtgatca gcacgcttgt gattacgatt cttgtgagct ggcttctgtc caaattccat 409381 gtcaagcgga ttcaaaagct gagagaagcg acagataaag tggcttccgg cgattatgac 409441 atccatttgg aaaacagcta cggggacgaa atcggcgtac tggcgtctga ctttaatatc 409501 atggcgaaaa aactaaagca gtcaagggat gaaatcgagc gccttgagaa gcggagaagg 409561 cagtttatcg ctgacgtgtc acatgaatta aaaacaccgc tgacgacgat caacggtttg 409621 gttgaagggt tgaacagcca tacgattcct gaggataaaa aggataaatg cttctcgctg 409681 atcagtgagg aaacgaagcg catgctgcgg ctcgtaaaag aaaatctgga ttatgaaaaa 409741 atcagatccc agcaaattac cttgaacaag ctagacgttc ctctgatcga ggtgtttgaa 409801 atcgtgaaag agcacttgca gcagcaggcg gaagaaaaac aaaacaagct gatgatccaa 409861 gtagaggatc acgtcatcgt acatgccgat tatgaccggt tcattcaaat tctcgtcaac 409921 attacgaaaa acagcatcca atttacgcaa aacggtgaca tttggctgcg cggaatggaa 409981 ggttataaag agacgattat tgaaattgaa gacacgggta tcggcattcc aaaagaggat 410041 attgagcata tttgggagcg attctataaa gcagatattt caagaacgaa cacagcatac 410101 ggtgaatacg gactcggtct ctcgatcgtc aggcagctcg ttgaaatgca ccagggcaca 410161 gtagaaatca agagtgaaga agggaaaggc acaaagttca tcatccgcct tcctttaacg 410221 gcaaaacagc aatagcatac agggcggcgc atcaactgat gcatccgcct tttttgcaca 410281 ccgcttcggt ttattgcgtg ctcccgaaaa caaagattgc gtgtttttcg ggttgggacg 410341 gcctataaac atgataaaat atgacataaa cagtttttga tgggagaggg tgaaggaatg 410401 aagagtgggg taattccttc ttcagcggtc ggtcaaaaaa ttaacgagtg gtacagatat 410461 atccggacat tcagcgtgcc ggatgccgaa gtgttaaaag ctgaaatcca gcaggaactg 410521 aaacacatgc agcatgattc caacttgctg ctttattatt cactaatgga attccggcac 410581 cagcttatgc tggattatct tgagccgtta gagaaattaa atatcgaaga ccagccaagc 410641 ctgtctgaat tatcaagaaa cattgacagc aaccaggcag atctcaaagg gctgctcgac 410701 tattacgtga atttttttcg cgggatgtat gaatttgata agcgggaatt tatttctgcc 410761 attacatact ataaacaggc ggagaaaaag ctctcctttg tcgcagacca tattgaacgg 410821 gctgaattct attttaaaat cgcggaagct tattattata tgaagcaaac gtatttttca 410881 ttgattaata taaaaaacgc ctatgaaatt tacgtggagc aggaaaccta taatgtgaga 410941 atcattcagt gccatttcgt cttcggggtc aacctgatgg atgaaagaaa tttcgaacaa 411001 gccgcacgcc atttcaaatt ggcgctcaac atggcccaag cagaacaaaa agcccagctg 411061 gttggaagag catactacaa tctcgggtta tgctattaca atcaagacct tctagaccct 411121 gccattgatt actttgaaaa agcggtctcc acatttgaaa gcagcaggat cgtcaattct 411181 ctcccgcaag cctatttttt aatcaccctg atttattata aacagggaaa acatgataaa 411241 gcttcggaat atcacaagcg gggctatgaa tatgctaaag aaacagacga tgcagactat 411301 gccgtaaaat tcgagttttt gcaatcccta tatctggatc agcccaatga agaaggaatc 411361 gaacgatgtt tccagtactt aaaaaataaa aatatgtacg ctgatataga ggatttagcc 411421 ctagaagtag caaaatatta ctatgaacag aaatggttta aactgtctgc ttcctacttt 411481 ctacaagttg aagaggcaag aaaacaaata caaaggagtg aaggtttgta tgaaattgaa 411541 atctaagttg tttgttattt gtttggccgc agccgcgatt tttacagcgg ctggcgtttc 411601 tgctaatgcg gaagcactcg actttcatgt gacagaaaga ggaatgacgt aagaacaagc 411661 cccttctcat tagcgagaag gggtttttct tttcaaaaaa acaccgcaag acatagtctt 411721 gcggtgccgc cttcatggag attacgttta tttagtagcc tcctacaaat gcagttccca 411781 caatgatcaa gaggataaat aacacaacaa tcaaagcgaa agaagttccg taacctgaca 411841 ttttgtgcac ctccttgcga gattgcttca gcaaatgctg caaaactgtg gcggacaggg 411901 tcccgcagag acggtcagca gcttagaagc cgccaacaaa cgcagtccct acgataatta 411961 atagaataaa caatacaacg attaaagcga aagaactgat gccgccgtaa ccgccgccgt 412021 tagagtatcc tgacataagg tttcacctcc ctatgaagga tactataaga tatgctgaac 412081 cgatccattt ggcagggata atagtggaca agagaaaaaa tgaagaattc ggctatatga 412141 aggtgatata aaaaaatagc gggcgctgcc gcccgctatt tatgtacgat taagagatca 412201 gcacgcccgc gaaaaattcc tggtataacg cttgaacggc ttttctttct tcggcttctt 412261 ttacgccaaa catcatgctc acttcagaag acccctgatt gatcatttcg atattcacct 412321 gtgcctctga taatgctttg gcggctcttg ccgttgtacc gacattgtgg cgcatcgctt 412381 cccctacaac cataatcagg gcgagatgat gctcgacgat gacttcatcg gcatgcaaat 412441 cctcttcgat ccgtttgatg acgctgcgtt cagtggcggc atccatttgc ccctgccgta 412501 aaatgattgt catgtcatcg attcccgatg gaacatgctc atacgtcaaa ccatgctcct 412561 ccaggatttg aagggctctg cggccaaaac cgatttctct gttcatgaga tacttgctga 412621 tataaatgct gcaaaaaccg gtgtcgctgg caatgccgac gacaggcccg tttgtgttat 412681 cccgcttgct gacgacgcgg gtgccttcgg ctgaggggtt gttcgtattt ttgatctgaa 412741 caggaatccc cgctctgaat gccggaatga gcgcttcatc atgaaacact gaaaaacccg 412801 cgtaggacag ctcccgcatc tctctatatg tcagctcgct gatttccttt ggattctcaa 412861 cgaaggacgg attgacagaa tacacagcgt ctacgtctgt aaagttttcg tacaaatcgg 412921 cttgtagtcc gttggcaaga atcgaaccgg taatatcaga accgctccgt gagaatgtga 412981 tcacatcgcc atccttgctg aatccgaaaa aaccgggaaa aatgatgagt ccgtcacgtt 413041 cccgaagacg atagaggttt tgataggatt caggaagaac ttgcgcgttg ccgggttcat 413101 ttgtcacaaa gaggccggca tccttcgggt ttacatattc cgctttgacg cctttataac 413161 ggaagtaagc ggcgatcagt ttggcattgt tatcctctcc gctggccttg actgcgtcaa 413221 ggtattgttc gggattgctt ttgtctcctt ctaaaagcgt aaacagatca tctctgattt 413281 tttcgataat gctttgcccc agctgaagct cattggcgat gagagcgtac cgttccacaa 413341 cagcttccgc cagttcaggt gcgctgcctg ttgccaaata ttgttctgca catgcgatta 413401 agagatcagt cactttcgta tcctcggcat agtgttttcc cggagctgaa acgactacag 413461 ctttccgtgc cggatctgag gtaacgatgt gaaacacctt gtcaagctgg gcgcctgaag 413521 caagtgagct gcctccgaat ttaacgacct tcatgtttac atctcctaat gtttaaaatt 413581 ttcacacaaa tttagtattt attatctctc tttcagtact gtaaatcaag ggggaatttc 413641 tttctcagga gaacatttgt atttttcacg aggaataatg ttaggtttgc tgaccgtatg 413701 cctgcgttat aaagataaat atggtaaaca gcctaacgtt ttgggatgga aaatggttag 413761 aatgattagt aaaattgata aatgactagg ttaatatttt taaagaatat tgactaaccc 413821 tataaaaatg gtaatatgta aatgataatg ataatcaatt actatatggc catattgttt 413881 tgagtccttg cggagtagga gatacgttct ttttgctgta aggatgtaag gaggcagcat 413941 gaagctacgt tacttattta ttctacttat catattagca gtcacatctg tatttatcgg 414001 tgtagaagat ctgtcgccgc ttgatctctt cgatttaagc aaacaagagg cgtcaacgct 414061 gtttgcaagc cgtttgccgc gattgatcag cattgtcatt gcgggattaa gcatgagcat 414121 ctgcggtttg attatgcagc agatcagcag aaataaattc gtgtcaccga cgacggcggg 414181 cacgatggat tgggcgaggc tcggcatttt aatttccttg ctgctgttta catccgccag 414241 tcctttaatc aaaatgctgg tcgcgtttgt ctttgccctt gcaggaaatt ttctgtttat 414301 gaaaatcctt gaaagaatca agtttaacga caccatcttt attccgcttg tcggtttaat 414361 gctcgggaat atcgtcagtt caatcgcgac atttatcgca tataaatatg acttgatcca 414421 gaatgtgtca tcatggctgc agggagactt ctctttagtc gtgaaaggaa gatacgagct 414481 tctttatctg agtattccgc tcgtcatcat tgcctatgtg tatgcggata aattcacatt 414541 ggccggtatg ggtgaaagct tttctgtcaa cctcggcctc aagtataaac gggttgtgaa 414601 catcgggctc attatcgtgt ccctgatcac gtctcttgtc attttgactg tcggtatgct 414661 gccgtttctc ggtttaatca tcccgaatat tgtatcgatt tacagaggag acaatctgaa 414721 gagcagcctg ccgcatactg tgctgttggg agcggttttt gtgctgtttt gcgatatact 414781 gggcagaatc attatcttcc cttatgaaat ctcgattggc ctgatggtcg gaatcatcgg 414841 cagcggcatt ttcctgttta tgctgttaag gagaaaagcc tatgcgtaac cagatgaaaa 414901 tagctttgct cgttggttta gccattgtat gtattggctt gtttttgttt tatgacttag 414961 gcaattggga ttacaccctg ccgagacgaa tcaaaaaagt cgctgccatt gtgctgactg 415021 ggggagcgat tgcgttttcg accatgatct ttcaaacgat tacgaacaac cgcatcctga 415081 cgccgagcat tttgggcctt gattctctct acatgctgat tcagactggc attatctttt 415141 tgttcggttc tgcgaatatg gtcatcatga ataaaaacat caactttatc atctctgttc 415201 tgctgatgat cctgttttct cttgttttgt atcagatcat gttcaagggt gaggggagaa 415261 atatcttttt ccttctgctt atcggaatcg tgtttggcac gctgttcagc agcctgtctt 415321 cttttatgca gatgctgatt gatccgaacg agttccaagt tgtgcaggac aagatgtttg 415381 ccagctttaa caatatcaat acggatttgt tatggctcgc gttcatcatc ttcctgctga 415441 caggcgttta tgtctggcgt tttacaaaat ttttcgatgt gctgtcgctc ggacgcgagc 415501 acgccgtgaa tttgggcatt gactacgaca aagtggtgaa gcagatgctg atcgtggttg 415561 cgattttggt ttctgtttca acagcgctag tcgggccgat tatgttttta ggccttctgg 415621 tcgtcaacct ggcgagagaa ttcctgaaaa catataagca ttcatactta atcgcaggct 415681 ccgttttcat cagcatcatt gcgctggtcg gagggcagtt tgtggttgag aaagtgttta 415741 ccttctcaac gacgctgagc gtcattatta attttgccgg cgggatttat tttatctact 415801 tgctgttaaa ggagaataaa tcatggtaga ggtcagaaat gtaagcaaac aatatggcgg 415861 gaaagttgtt cttgaagaga cgtcagtcac gattcaaaag ggcaaaatca cctcgtttat 415921 cggtcctaac ggcgccggca aaagtacgct gctgtctatc atgagccgcc tgatcaaaaa 415981 ggattccggc gagatttaca tagacggaca agagattgga gcatgtgaca gcaaagagct 416041 tgccaagaaa atgagcattt tgaagcaggc gaaccaaatc aatatcaggc tcacgatcaa 416101 agacctcgtc agttttggca ggtttccgta ctcacagggc cggctgacag aggaagactg 416161 ggttcatatc aaccaggcgc ttagctatat gaagctggaa gacattcaag acaaatactt 416221 ggatcagctg agcggcggac agtgccaaag ggcatttatc gccatggtca ttgcccagga 416281 cacagattat atctttctgg atgaaccgct gaacaatctg gatatgaaac actcagttga 416341 aattatgaaa ctgctgaaac ggctggtaga ggagcttgga aaaacgatcg tgatcgtcat 416401 tcacgatatc aattttgctt cagtctattc tgactatatc gtcgctttga aaaacggccg 416461 aatcgttaaa gaaggaccgc ctgaagaaat gatagaaaca tcagtgcttg aggaaatcta 416521 cgatatgacc atcccgattc agacgattga taatcaaaga ataggtgttt atttttctta 416581 atatatagaa gaggtgagga gcatgaaaaa gttcgcgtta ctattcatcg ctttggtcac 416641 tgccgttgtc atttctgcat gcggaaacca aagcacaagc agcaaaggtt ctgatacaaa 416701 gaaagaacaa atcacagtga aacaccagct cgacaaaaac ggcacaaaag taccgaagaa 416761 ccctaaaaaa gttgtcgtat ttgactttgg aagcttagat acattagata aactaggact 416821 tgatgatata gtagcgggcc tgccgaaaca agtccttcct aaatatctgt ccaaattcaa 416881 ggatgacaaa tacgctgatg tcggcagctt aaaagagcca gacttcgaca aagtggcaga 416941 attagatcct gatctgatca ttatttcagc aagacaatct gagtcttaca aagaattctc 417001 taaaattgcg ccgacgattt accttggtgt agatacagcg aagtacatgg aatcatttaa 417061 atcagacgct gaaacaatcg gtaaaatctt tgataaagaa gacaaagtga aagatgagct 417121 cgcaaacatt gatcactcaa tcgcagatgt aaagaaaacc gctgaaaagc ttaacaaaaa 417181 cggtctcgtc atcatggcga acgatggaaa aatcagcgcg ttcggcccta aatcaagata 417241 cggcctgatc catgacgtat tcggcgtggc tccggctgat caaaacatca aagcgtctac 417301 gcacggacaa agtgtttctt acgagtacat ttcaaaaaca aaccctgatt acttgtttgt 417361 tattgaccgc ggtacagcaa tcggagaaac atcatctaca aaacaagtcg tggaaaacga 417421 ttatgtgaaa aacgtaaacg cagtgaaaaa tggtcatgtc atctaccttg attctgctac 417481 ttggtattta tcaggaggcg gacttgagtc tatgacgcaa atgattaaag aagtgaaaga 417541 cggtttagaa aagtaaaacc aaaaagagcc tccgctaaat agcggggctc tttttttgtt 417601 aatcagcgtg ccggctgctg ttcggcaggg cgctgaggtt tctttaatgt gaatgagaga 417661 aggaagccga caagtgcaat gacggcagcc actataaaag cggcgttcat gccgtgcagg 417721 gcggcgtgct tcacatttgt cgtgcctgca tgtgccgcct ggttgctcat cacggaaacc 417781 aatagtgcgg ttccgatcga gccgccgact tggcgaatcg tgttgttcat cgcagttccg 417841 tgcggaatca agtggcgcgg cagcgcattg attccggctg ttgtcaccgg catcatgatc 417901 atggcggtgc ctaagagacg aacggtgtat aaaacgacaa tccaagcgag tgacgtatgg 417961 tcagtcagct gcataaacgg cagagatgtc aggaagatga tgcagaaacc ggcaatcgcc 418021 agccctcttc cgccgacacg gtcaaaaatt ctgccgataa tcggcgacat aaagcccatc 418081 acaacggctc ccggcaggag cataagccct gtatcaaaag ctgtgacgtc tctgacattt 418141 tgtgtataaa gcggcaggat ggtttccgta ccgatcaata atgcaaagac gagggttccc 418201 agcagtgttg ttaagctgaa aacgccaaac gtgaagacgc ggaattccag catcggtttt 418261 ttaagcttca tttgtcttgt gataaacaag agcagcgcga tgacacccac cagcagtgaa 418321 atcaagacgg ttgaactgga ccagccataa gagccgacgc ttgagaagcc gtacagaagg 418381 ccgccgaacc caaatgttga aaggatgact gataaaatat caatctgtgt ttttcttaaa 418441 gtcgtcacgt ttttcatcag gatgctggca agaatcaaat caatcacagc aaacggaaga 418501 ataatataaa acaatgatct ccaagagaaa gcttcgacag cccatccgga aagagtcggt 418561 ccgatcgcag gcgcgaatga gatgaccaat ccgaccatac ccatagcctg gccgcgcttt 418621 tcaatcggaa agattgtcag gaatacagtc tgcatgagcg gcatcataat gccggctcca 418681 gccgcttgaa tgatacgcgc tgtcagcaga accgggaagt tcggcgcgaa cgctccgacg 418741 actgttccgg cagtgaaaat gctcattgct gtgatgagca gcgcccggct tgtgaatttc 418801 tcaattaaaa acgcggtaat cggaattaaa atcccgttgg ttaacataaa tgatgttgtc 418861 agccattgtg cttggttggc atcgacattg aaatccctca tgatatgggg aagtgcagta 418921 atcaacaatg tctggttcaa aatcgccaca aacgctccgg ctaacaaaat gccgacaatg 418981 acagaacggt taaaaggttt ttgttcaata cttgtgttca atacatatcc cttcttttct 419041 ctaagtaatt aacagtgttt ttaacatgga aacgggctgt gttaaaacac cggtttgttc 419101 cagatagcca atcagtgatt tgagtaaaaa agcgcggggt tcttccttct tcgcttcttc 419161 ctccagcata gcggctgcgg atgtcagttc atctacgtca tagtccgcgg cggacaggga 419221 agagatgcct ttatgtaatt ccttcaggct ttccgataat aggactgatt tatcctttgg 419281 cttgtaggag gatgctgaat gaatataaag ctcgatggct tcgggcggaa gaagagactg 419341 gcgggtttcc ctgtttttga taatctgatt gagggtgctg atgataaact ctgcgatcgg 419401 gtcaagctca agcggttttt cctcgatttt gatcagcatt aaaaactcac gcatcatgcc 419461 gtgaagaatg ataaccaaat cccacacaaa cgggagaatg gtttctccat acgcctggat 419521 cagcgaatcg cggtgccagc agataatcgt cgatctggtc tgatggatat gctgtttgac 419581 ccggtcattg tgcagcttgg ggtttccgta ggtcagcata ttgaaaaact gctgattccg 419641 cctgaagccc tccagttcca ttttgacctt ttgcgtcaaa cgctcctccg gtgtaagtgc 419701 tgtattttcc tgaagtcttg aggccgcggc caccatttgc ttctggttaa atgacagcag 419761 ctccaaaagc agatcttctt tagattggaa cagcttatat atcgaagctt ttgacatctt 419821 acattcttct gcgatcgcct gcatggaaac cgacgtaaaa tccttttccg aaaaaagctt 419881 tcgcgcggct aacaagatat ctgttttttt atcaagcatc tcatggcttc cttctttctt 419941 gaacattaga aaacccattg gttcacagaa aaccaatgag taacaatgaa aaaattttac 420001 cagataaaca aaatagaagt caatggattt taaccgggta aatgaaaggc ctgccggaaa 420061 atccgacagg ccgaataaga gcttattttt caactttaaa tccttgtttt tcaagcattt 420121 cacggatgtg cggatagtac aggcgctcat agtaggaagc gatgctctgt gaccagtttc 420181 ttgtttcttt tccgtttgtc cgtttattca tgtattcaga catctgttcg tcgtatgcct 420241 gaatgtgaga cgtcagctca tcctgattca aataagtttc ctgatgattg acagcttcct 420301 gcggcaagcg cggttttttc gctgaacggt cggcaggatg cccaatgaca aggccggata 420361 aagggaacac gtatttcgga agctcaagca gttcgatcag ctcttgaggg tttccgcgaa 420421 ctgcaccgat cggaactgtg ccaagtccga gtgactcagc cgctgctgtt gctgtgccga 420481 gggcaatacc agcgtctact gcgccgacaa gaacagattc caatccattt gtgatttcca 420541 ttttgaaatc atgcagatct tcaagcgcaa ttttggcccg gttaaaatct gcgcagaaca 420601 gcaggaaaac aggagcttga tcgatccatg gctggccgcc tgccagctcg gagattttct 420661 ttttgcgctc tttatcctgg actgtgatca cagtcacttg ctgtccgttg atagaagaag 420721 gggctgattg caccgcttca atgatttggt ccaattgctc ctgagctaca ggctcatctg 420781 tgtagctgcg aatcgagcgg tggtctgtta aagatttaat cacttcattc atatgagaca 420841 cccttccttt actcgctaag ctctgtgcgg acaacatcaa gaggagcgct cagcagttct 420901 tttccttttg cgacaaaccc ttggaaatgc gcagtttcgt tatggaattt cattgccgct 420961 tcatctttcc atttttcaag catgacaaat gtattttctt cgcctacttt ttcgaatagg 421021 tcgtattgcg cgttgccttc ctcagctctt gaatgctgaa caagtgattg agcctcgctc 421081 aaaaattcct cgcgtttttc tggttttact ttgatgtaag cttgtaatac gatcatgtaa 421141 atctcctccg tcgttatgcg aatttattgt tcgaatttca tcgaactaaa tgtaacatgt 421201 attctaaatg aggtaaagga aaaaccctta tatagtaaaa ttgtcattct aattgttgta 421261 tgatacattt gtgtcatgaa cattccaaac catccagaaa cagaaacatt gcagctgaca 421321 aaggttcttc atgcacttag tgatccgctt cgtttagagc tcgtcaagca attagctgaa 421381 gcaaaagaaa aaacgtgcag cacctgtgca gatgtgcagg ttgccaaatc gactttgtcg 421441 catcatttta aagttttgag agaatcaggc atcgctcaag ttcggataga aggaaagcgc 421501 cggtattatt cgcttcgcgc tgaagacctt gaaaaggcat ttccgggact gcttgaagcc 421561 gtgctgaatg tagaccagga ccgctggtga atcaatcccc tgtaacgggg atttttttat 421621 gtccgtaaac cgctttgaaa agccgctgca caccctcctg aatatcttct tccttcagcc 421681 gtgcaaagcc gataatgaga gcaggcctgc ccgtttgccg cttgttttcc ttcaagttaa 421741 atcggctcat tccgaatatt tcaagctgca gcccggcagc atgtgacagg atgtcttgtt 421801 cggtgcgcct ggtatcaaat tcggtaacaa aatgcagccc cgcatttgcc ccttttacgg 421861 taacctctcc gctgaactct gcttctaaag cggtgatcag gcgttctctc ttttctttat 421921 aatgctgctt catttttttt atatgcttct gatattcacc agactcgata aattcctgca 421981 gggtgagctg tgtgagtgat gagcaagtct gcagatcata gccccgctgt ttgtatgccc 422041 tcaacagctc aggcggcaac accatatagc tgatccgtaa gccggggaga agggactttg 422101 aaaaggttcc catatagatg acattttgaa aacggtcgag gctttgcagc gccggaatac 422161 tgtctacatc atatgtgaat tcactatcat aatcgtcctc aatgatatat cggcgcggct 422221 cctcggctgc ccagttcagc agctgaattc ttctggatac aggcataatc gttccggacg 422281 gaaactgatg cgacggggtg gtcaccagca catctggctg ctgtctggtg atttcagcaa 422341 tcgacatgcc tttttcatcc agcatgatcg tctttacttg ttttccggca ttcttcaaaa 422401 gctgatacat gcgcctgtag ccaggctcct ccatcgcata cacggcttcc ttgggtaaaa 422461 gctcagtcaa cagctgcatg agcacctgtg tgcctgcccc tatgatcatt tgttccggcc 422521 tgcattttac acccctcgtc agggaaatga gcctcgtaat ggccgctctc acttcatata 422581 tcccttgcgg atgtgacata tcgccgagcg tgcggtatga gcgggaggcc gctttttgct 422641 cgcagcggaa ccagcttttg atcggaaaat ggtctgtatc ggaactcatg tgtgaaaacg 422701 atatccaatc gctctggtcg atgtgaatct cttttaggtc atccggcagt gcaaatggag 422761 ggtgctcctc ggcggaaaac atgtctagtt cctccacgaa gaaacccttt cgttcaatgg 422821 cgtacaaata cccctcagcc agcagctgct gataggctga attcactgaa tttacgctga 422881 ccttgagatt ttcagccagc tcccgcttgg agggaacctt cgagtgcggc agcagattgc 422941 ggctgaggat ttcttttttc agcttttgat aaatttgctg atagatataa tcggcttgtt 423001 ctgaacgatc gagtgtaatc gtgatatcca ttttgtagtt tctccttctg ataccatcaa 423061 aaagttataa ttggtacttt tcatcatacc aaagagaagt cagaatgata agaaaatacc 423121 gacaggggga tattcacatg agtcaaacaa cagcaagcat cacaactgca caatggcagc 423181 aaaaacggga tcaatttgtg tcaaaaggtg tgagcaacgg caaccgcagt ctggcggtca 423241 aaggagaagg ggccgagctg tacgatctgg atggccggag atttattgat tttgcaggcg 423301 ccatcggcac gttaaatgtc ggacactcgc atccgaaggt ggttgaggct gtgaagcggc 423361 aggcggagga gctgattcat cctggtttta atgtcatgat gtacccgact tatatcgaat 423421 tagcagaaaa actgtgcggc atcgcgccgg gcagccatga gaaaaaagcg atttttctta 423481 actcaggggc agaagcggtc gaaaacgctg tgaaaatcgc cagaaagtat acaaagcgcc 423541 aaggcgttgt ctcgtttaca cgcgggtttc acgggcgcac gaatatgacg atgagcatga 423601 caagcaaggt aaaaccttat aaattcggtt tcgggccttt tgcgccagag gtttatcaag 423661 cgccgttccc ttattattat cagaagccgg ccggcatgag tgatgaaagc tatgacgata 423721 tggtcattca agcattcaat gatttcttta tcgcttcagt ggcgcctgaa acggtggcgt 423781 gtgtcgtgat ggagccagtg cagggagaag gcggatttat tattccttcg aaacggttcg 423841 tacagcacgt cgcttcattc tgcaaagaac acggcattgt ttttgttgct gatgaaatcc 423901 aaaccggctt tgccagaact ggcacttatt tcgcaattga gcactttgat gtagtgcccg 423961 atctgatcac ggtttctaaa tcgcttgcgg caggcctgcc attaagcggt gtgatcgggc 424021 gtgcggaaat gcttgatgcg gcagcgccag gggagctggg cggcacgtat gccggcagcc 424081 cgctcggctg cgcggcggct ttggcagtct tggatattat cgaagaagaa ggactgaatg 424141 agcgatctga agaaattggc aaaatcattg aagacaaggc gtatgagtgg aaacaagaat 424201 tcccgttcat cggtgacatc cgcagactcg gggcgatggc cgcaatcgaa atcgtcaagg 424261 atcctgacac gcgtgagcct gataagacaa aagcagcagc gatcgcggcc tatgcgaatc 424321 aaaacggatt acttttgctg acagcgggaa ttaacggtaa tatcatccgc tttttgacac 424381 cgctcgtcat ctcagacagc ctattaaatg aagggctcag catcttggag gcgggcctgc 424441 gagcttaatc attggaaaga aaatggccgg gtctgctatc attttaagta atcatgaaaa 424501 gaaaggaatg ttcaatatgc cagatcaatt aacggtctac aacccggcta cgggcgagga 424561 gatcaaaacg attcctcagc aatcagccac agaggtagaa gaagccattg aacgttcaca 424621 tcaagcgttt aaaacgtggt ctaaaacatc agcgaacgaa agaacgtctc ttttgaaaaa 424681 atggtatgag ctgattgttg aacataaaga agagcttgca gatttaatta caaaggaaaa 424741 cggaaaacca taccaggaag cagtcggcga ggtactttac ggcgcaggct atatcgaatg 424801 gttcgcagag gaagcgaagc gtgtgtacgg aagaacggtc ccggccccga caactggtaa 424861 acgaattgtt gtcacacgcc agccggtcgg ccccgttgct gctatcacgc cctggaattt 424921 cccgaatgcg atgattacac gcaaagcggc gcctgctctt gccgccggct gtacatttat 424981 catcaagccg gcgccggaca caccgctgtc tgcttatgaa ctagcgcgcc tcgcatatga 425041 agcgggcatt ccgaaggatg ttcttcaggt tgtgatcggc gatggagaag aaatcggaaa 425101 tgtgttcaca agcagtccga aaatccgcaa aatcacgttc acaggctcaa cacctgtagg 425161 gaaaatcctt atgaaaaaca gcgctgacac cgtaaagcac gtctcaatgg agctcggcgg 425221 acacgccccg ctgatcgtag atgaagatgc ggacattgac cttgccgttg aacaggcgat 425281 ggcgtccaaa taccgaaacg ccggccaaac ctgcgtatgt gccaaccgcc tgatcgttca 425341 tgaatccatt aaagatgaat ttgctgcgaa actgagcgag caagtgtcta agctgaaagt 425401 cggaaatgga cttgaggaag gcgtcaatgt cggcccgatt atcaacaaac gaggcttcga 425461 aaaaatcgtc agccaaatag atgatgcggt tgaaaaaggc gcgaaagtga ttgctggggg 425521 cacatatgac cgaaacgatg acaaagggtg ctactttgtg aatccgacag tgctcaccga 425581 tgtcgatacg tccatgaaca tcatgcatga ggaaacattc ggcccggtcg ccccgatcgt 425641 cacgttttct gatattgatg aagcgattca gcttgccaac gatacaccgt atggcttggc 425701 tgcttacttc ttcacagaaa actaccgccg cggcatctat atttccgaga atctagagta 425761 tggcattatc ggctggaatg acggcggacc gtcagcggtt caagcgccat tcggcggaat 425821 gaaagaaagc ggcatcggcc gtgaaggcgg ttcagaaggt atcgagccgt accttgaaac 425881 aaaatatttg tccatcggtt tataaaagaa tgcacgctcc tgagagctgc cggattttcc 425941 ggcagctctt tttgtgttcc ggcgaataat cacaacaatt ccagccaaaa taacagcaaa 426001 tacattttga aagaaggttc cccaacaatg gatttattat tggctcttct cccggctttg 426061 ttttggggga gcattgttct cttcaatgtg aaattaggcg gcgggccgta cagccagaca 426121 ctgggaacga cgatcggggc actcattgtt tctatcgtta tttacttttt tgttcagccc 426181 gttctgtccc ttcgcatttt tattgttgga atcgtatccg gcttattttg gtcacttgga 426241 caggccaacc agttgaaaag cattcaattg atgggcgtgt cgaaaacaat gccgatttcc 426301 acaggaatgc agctcgtttc cacctcgctg ttcggtgtga tcgtgttccg cgaatggtca 426361 acaccgattg cgattacgct tggcgttctc gctttgatct ttatcattgt gggaatcatt 426421 ctcacgtcct tggaagataa gaatgataaa aaagagggcg agccaagcaa tttgaaaaag 426481 ggcattttga ttctccttgt ttcgactctt ggttatttgg tttatgtagt cgtggctaga 426541 ttattcaatg tgtccggctg gtccgcgctg ctgccacagg caattggcat ggtggtcggg 426601 gggttagttt taacctatag acacaaaccc tttaacaagt atgcgatcag aaatattctc 426661 ccagggttaa tctgggcagg cggaaatatg tttttgttta tttctcagcc gcgagtcggc 426721 gttgcaacga gcttttccct ttcacaaatg ggaattgtca tttctacgct cggcggtatt 426781 ttcatcctgc gtgaaaagaa aacgaaacgc cagctaatag caattgcgat cgggattatc 426841 ctgattattg ccgccgccgt attcttagga atcgccaaaa caaattcata acaaatggag 426901 gaggatgtat atgtatccgg atttaaaagg aaaagtcgtc gctattacag gagctgcttc 426961 agggctcgga aaggcgatgg ccattcgctt cggcaaggag caggcaaaag tggttatcaa 427021 ctattatagt aataaacaag atccgaacga ggtaaaagaa gaggtcatca aggcgggcgg 427081 tgaagctgtt gtcgtccaag gagatgtcac gaaagaggaa gatgtaaaaa atatcgtgca 427141 aacggcaatt aaggagttcg gcacactcga tattatgatt aataatgccg gtcttgaaaa 427201 tcctgtgcca tctcacgaaa tgccgctcaa ggattgggat aaagtcatcg gcacgaactt 427261 aacgggtgcc tttttaggaa gccgtgaagc gattaaatat ttcgtagaaa acgatatcaa 427321 gggaaatgtc attaacatgt ccagtgtgca cgaagtgatt ccttggccgt tatttgtcca 427381 ctatgcggca agtaaaggcg ggataaagct gatgacagaa acattagcgt tggaatacgc 427441 gccgaagggc attcgcgtca ataatattgg gccaggtgcg atcaacacgc caatcaatgc 427501 tgaaaaattc gctgacccta aacagaaagc tgatgtagaa agcatgattc caatgggata 427561 tatcggcgaa ccggaggaga tcgccgcagt agcagcctgg cttgcttcga aggaagccag 427621 ctacgtcaca ggcatcacgt tattcgcgga cggcggtatg acacaatatc cttcattcca 427681 ggcaggccgc ggttaaacat aaaaagcgac ccagacatga catctggatc gctttcttta 427741 ttaggcacgc tttttcttta caagtgctgc tacagataaa ataatggcag ccgcagacag 427801 caccatcgct gtaatgtcta gagctgaaga acctgagttt tcggaatcgt cttctgtttt 427861 cgtggcgccg tgctcatctg tcacttgctt tgcagacgtg atgtttgtaa tggaatgagg 427921 tgtatcggca tcctcgtcac ctgtccactc aacaatgctg ccgtctttgt aatattggta 427981 tgcgtcccaa gcagcttcct ccgctttgtc agggtttttg gcaacaaagg taaactgctg 428041 gaactggcct tcctgaatgc ctccgtcagt cgcctcccat gtcacggata ctgatttgtc 428101 atcatgtttt tgagtggaaa ccttccagcc cggaattggc tcatattgct ggaattcaac 428161 atccttcggc attttgagga caaccttcgt tgtcggcaga tttttctcag aaggaacctt 428221 cattgtatac gtttcccaag agcctgcagc agactcagcc ggttttacag aaacatgcgc 428281 gctggcaggg gccgtaaaga ataagaggga gccgacaata gccggacata gtgtcaatgc 428341 gatttttttc aacaacgtaa acactcctta attggtcttt gtaaacatga tattgatttc 428401 gttaaagtcg ccggtcaggc cgtggacttt gatcttccag tttccttttt cattaatcga 428461 caggttttga tcttggaaga cgccttttgt tttttctttt aatgtaaagg tgcttttgtt 428521 ttcgctgcct gacaggcctg ttttataaac ggttaacgtg atttgctgga tgtttttcac 428581 gggatcaccg ttatggtcgg tgacccgcag ctcaaaaaca ttttttccag gctggtttgg 428641 gctgatgctg agagaaacgc tttgtccgtt ctctatcgct ttggtttggt agaacggttc 428701 cggcgctggc tcaggcgggc ttggcaggct tgtaaacacg gccgctgtga tcaatacagc 428761 gatgccgatt gcccactccg ctttcaacgt tcggctgatt cctgtgcggc gctgctttct 428821 ggtaagcaga aaatgaattg cgcctaagac cagcatgaaa acaaacagcc cgcttttcac 428881 taaaagagct tgtccgtacg ctgtatggaa cagtgaatcc attgaacgaa tgatgaaaaa 428941 tccattgagc aagcctgaaa acaaaatgac gccgactgca gtgagcgccc atggggagaa 429001 ccgtctgacc gtctcccacg cgagcgtttt gtcaggctgc ctccattctt ttgagagcag 429061 caaaacgagt gccgctattc cgccgaccca gatggaagcg gaagttaaat gaaggaaatc 429121 catcaaaatg ccgaccgttt tttcttcaac gacagcagca tgcccggtaa acgccttggc 429181 aagcaggaga ccgaaaaaga aaatgagcgg cgctgtccaa tagccaaagg atgaaaagcg 429241 gtttttccgt atcgcaggga tgacagacag tgcgagcagc acgaacagcg cagcctgtat 429301 gatccaaatg gagccgcctg ctgtctcaaa cagtgtttct ctgatgtagc ccggctggaa 429361 tgcgctgccc cagccgccgc ctgcgttcgc ttttgtctga atcggaagct gaagcaaaag 429421 cgccagcccc aatgctgcga tcgagccggt caggatacgt ctcgtccgtt tgacgagctg 429481 ttctgatttc cctttatacc agaaaagatg gaagaaaacc gttccgataa acagagataa 429541 ggctgtatac agaatcgcgc gatctgctgc tgttcccgga ttcagcgctg aatcggctgc 429601 tttttggctg ctgaatccgc catccgcttt cccgatactg aacggaatga cgccggaaac 429661 aggatgtcca tccgcggata cggcattcca ttccgctctg tacacatctt taggcagatt 429721 cttcttcagc ttcactgtca tgatgtgatg attatctttt ttgatttcag tcttgtccgt 429781 atccacacgg tcgccgtttg aattatagac tttaatgtaa tgaaaccctt cttcaaccgg 429841 ttcattaaat tcgatttcca cctgcgcagg ggcgcttttt aattcgctgt tttccccagg 429901 tgaagatttg acaatatagg cgtgagcaaa gcttgttttc ggcaggaaaa caagaaaaag 429961 cagaaggatg atccaccatc tgtttcgctt catcactcag acaccacctt ccgctgtatg 430021 tgttgtgtta tttcttggtg caggtgcagc gtttctttcg gtcttgaagc atgtcttcca 430081 gcgcttggtc gaaagtgcag acggctccgc cgaatccttt ttgaaatcgt tcggcatggt 430141 caagtgtcgc aaacggaatg gcctgcggct ggcagcagtg caggtttaat tcagcattta 430201 cgacgaaata agccgaaccg gcactgacgg ttgtctgtaa cagaaaatct ctgcaaatca 430261 agtgtgaaac ctcttccgtt ttatccgcgt aacgcaaaaa cgcgcaatgt gcgcagcata 430321 gctgttcaat gtcttggttt accgtaatca gctgaaccga atgagcttga ttgacgggct 430381 tcaagcaata gctgcacata tgatctgttt gaggtgttcg gacggggagc gtgatgccgc 430441 cggccgtttt aatgacctga tttgactgaa ccagctgatt gacatctcta tataccgtca 430501 tttccgaaac gccgaacctt gcgctgatgt cagaaattct aagcgagcct tcttctttca 430561 gccacttcag tatgtgttgc tgtctattaa tcggaagcat tcatacaccc tcttcattaa 430621 gatctattta agcgtagagg attttagaga cggagacaag taagtggatg ataaaaaatg 430681 tgaaaatgtg ttgaacagca acaaaacgaa acagaaggga ctctggtata atagacagat 430741 ggaatagaaa gtgaggaata ccctatgaaa gaaacaccat gcccgaactg cggcaaacct 430801 ttgacaggcg atatggtcag atcatcaaat gtgccttgtc aatttcgctg cggccactgc 430861 cgggaacggc tttatgaata taaagtttca gctccgatta tgctggtatc attagcggcc 430921 atcgtgctgc ttatttatct tttgatgctc ctccgcaatg cggcaggctc agtgctgcca 430981 gctgtacagc acgtgccgat ggctgtattt gcgcttgtgt gcgcgtatcc cgtttttatt 431041 gtgagtgagc ggatgattgc aaagtacgtg attcaaaatg gcaacatcat ttatagagga 431101 aagagaaaag gctcctgaaa ccaggagcct ttttattttt aaaaaattgt cacagtcatg 431161 tgccaaagtc ctctttactt tcaattgtat agggactgta agcgttttaa catagagtca 431221 aagggaagca tcattctctg aacatatttt tgtatcttac agcgacaaac aaaacaggga 431281 gggtttatat atgcagcagc aagaacagca gcaaggcggc atgaaagtga aagtgcaacg 431341 ctttgggagt tatttgagcg gaatgatcat gccgaatatc ggcgcgttta tcgcgtgggg 431401 tatcattacc gcgctgttta ttccggcagg atggtttccg aatgaacagc tgaacacgct 431461 ggtcagcccg atgattacgt atttattgcc gcttttgata gcgtatacag gcggaaaaat 431521 gatctacgac caccgcggcg gagttgtcgg agcgacagcg gcaattgggg tgattgtagg 431581 atcggatatt ccaatgtttt taggcgcaat gattatgggt ccgcttggcg gatacctcat 431641 taaacagact gataaattat tcaaggataa agtcaagcaa ggctttgaaa tgctgatcaa 431701 caactttacg gcagggattg tcggcgcggc tttaacgatt ctcgcgtttt acgccatcgg 431761 cccggttgtc ttgacgctaa ataaattgct ggcggctggt gtggaagtca ttgtacacgc 431821 taatttactg ccggtagcca gtgtttttgt agaaccggcg aaagtgttgt tccttaacaa 431881 cgccataaac catggaatct taagcccgat cggaatcgag caagcatctc aaacaggaaa 431941 atcaattctg tttttagtag aagcaaaccc tggaccgggg ctcggcattt tgctggccta 432001 catgttcttt ggcaaaggat cttcaaaatc aacggctccc ggtgcggcga tcatccattt 432061 cttcggaggg attcacgaga tttacttccc gtacattctg atgaaaccgg ccctgattct 432121 cgcagccatt gccggcggag caagcggact cttaacattt acgatcttta atgccggact 432181 tgtcgcggca gcgtcaccgg gaagcattat cgcattgatg gcaatgacgc caagaggagg 432241 ctatttcggc gtattggcgg gtgtattggt cgctgcagct gtatcgttca tcgtttcagc 432301 agtgatcctg aaatcctcta aagctagtga agaagacctg gctgccgcaa cagaaaaaat 432361 gcagtccatg aaggggaaga aaagccaagc agcagctgct ttagaggcgg aacaagccaa 432421 agcagaagaa gcgtctgagc tgtctcctga aagcgtgaac aaaattatct ttgcgtgtga 432481 tgcgggaatg ggatcaagtg ccatgggggc atccatctta agaaacaaag tgaaaaaagc 432541 ggagcttgac atcagtgtga ccaacacggc cattaacaat ctgccaagcg atgcggatat 432601 tgtcatcacc cacaaagatt taacagaccg cgcgaaagca aagctgccga acgcgacgca 432661 catatcagtg gataacttct taaacagccc gaaatacgac gagctgattg aaaagctgaa 432721 aaagtaatct tatagaaaga gagtgattgt catgcaagta ctcgcaaagg aaaacattaa 432781 actcaatcaa acggtatcat caaaagaaga ggctatcaaa ttggcaggcc agacgctgat 432841 tgacaacggc tacgtgacag aggattacat tagcaaaatg tttgaacgtg aagaaacgtc 432901 ttctacgttt atggggaatt tcattgccat tccacacggc acagaagaag cgaaaagcga 432961 ggtgcttcac tcaggaattt caatcataca gattccagag ggcgttgagt acggagaagg 433021 caacacggca aaagtggtat tcggcattgc gggtaaaaat aatgagcatt tagacatttt 433081 gtctaacatc gccattatct gttcagaaga agaaaacatt gaacgcctga tctccgctaa 433141 aagcgaagaa gatttgatcg ccattttcaa cgaggtgaac tgacatgatc gccttacatt 433201 tcggtgcggg aaatatcggg agaggattta tcggcgcgct gcttcaccac tccggctatg 433261 atgtggtgtt tgcggatgtg aacgaaacga tggtcagcct cctcaatgaa aaaaaagaat 433321 acacagtgga actggcggaa gagggacgtt catcggagat cattggcccg gtgagcgcta 433381 ttaacagcgg cagtcagacc gaggagctgt accggctgat gaatgaggcg gcgctcatca 433441 caacagctgt cggcccgaat gtgctgaagc tgattgcccc gtctatcgca gaaggtttaa 433501 gacgaagaaa tactgcaaac acactgaata tcattgcctg cgaaaatatg attggcggaa 433561 gcagcttctt aaagaaagaa atatacagcc atttaacgga agcagagcag aaatccgtca 433621 gtgaaacggt aggttttccg aattctgccg ttgaccggat cgtcccgatt cagcatcatg 433681 aagacccgct gaaagtatcg gttgaaccat ttttcgaatg ggtcattgat gaatcaggct 433741 ttaaagggaa aacaccagtc ataaacggcg cactgtttgt tgatgattta acgccgtaca 433801 tcgaacggaa gctgtttacg gtcaataccg gacacgcggt cacagcgtat gtcggctatc 433861 agcgcggact caaaacggtc aaagaagcaa ttgatcatcc ggaaatccgc cgtgttgttc 433921 attcggcgct gcttgaaact ggtgactatc tcgtcaaatc gtatggcttt aagcaaactg 433981 aacacgaaca atatatcaaa aaaatcatcg gtcgctttga aaatcctttc atttcggacg 434041 atgtgacccg cgtagcgagg tcacctctca gaaaactggg agaaaatgat agacttgtag 434101 gcccggcaaa gaaaataaaa gaaccgaatg cactggctga aggaattgcc gcagcactgc 434161 gcttcgattt caccggtgac cctgaagcgg ttgaactgca agcgctgatc gaagaaaaag 434221 gatacagcgg cgtacttcaa gaggtgtgcg gcattcagtc ccatgaaccg ttgcacgcca 434281 tcattttaaa gaaacttaat caataaccga ccacccgtga cacaatgtca cgggcttttt 434341 ttactatctc gcaatctagt ataatagaaa gcgcttacga taacagggga aggagaatga 434401 cgatgaaaca atttgagatt gcggcaatac cgggagacgg agtaggaaaa gaggttgtag 434461 cggctgctga gaaagtgctt catacagcgg ctgaggtaca cggaggtttg tcattctcat 434521 tcacagcttt tccatggagc tgtgattatt acttggagca cggcaaaatg atgcccgaag 434581 atggaataca tacgcttact caatttgaag cagttttttt gggagctgtc ggaaatccga 434641 agctggttcc cgatcatata tcgttatggg ggctgctgct gaaaatccgg agggagcttg 434701 agctttccat taatatgaga cccgccaaac aaatggcagg cattacgtcg ccgcttctgc 434761 atccaaatga ttttgacttc gtggtgattc gcgagaacag tgaaggtgaa tacagtgaag 434821 ttggcgggcg cattcacaga ggcgatgatg aaatcgccat ccagaatgcc gtgtttacga 434881 gaaaagcgac agaacgtgtc atgcgctttg ccttcgaatt ggcgaaaaaa cggcgcagcc 434941 atgtgacaag cgccacaaag tctaacggca tttatcacgc gatgccgttt tgggatgaag 435001 tctttcagca gacagccgct gattatagcg gaatcgaaac atcatctcag catattgatg 435061 cgctggccgc tttttttgtg acgcgtccgg aaacgtttga tgtcattgtg gcgagcaact 435121 tgttcggtga tattttaacc gacatcagct caagcctgat gggaagcatc ggcattgcgc 435181 cttctgcgaa catcaatcca tccggcaaat atccgtccat gtttgaaccg gttcacggct 435241 cagctcctga cattgccgga cagggccttg ccaatccgat cggccagatt tggacagcga 435301 agctgatgct cgaccacttc ggagaggaag aattgggggc gaaaattctg gatgtaatgg 435361 agcaagtgac tgccgacggc atcaaaacac gcgacattgg gggacaaagc acaacggctg 435421 aggtcactga tgaaatctgt tcgcgcttaa gaaagctctg atgaatcagg ccggtggcag 435481 atggctgccc cggcctgtcc atttccttac gaaaatttcc acgaaagtct aaccaagcag 435541 atccaaatgc tgtataataa tttggaattc ttaggaaagc atcgggtgaa ggaagttgaa 435601 tgcaaaaaca atcacgttaa agaaaaaaag aaaaatcaaa acgatcgttg tactcagtat 435661 cattatgatc gcagctctca tttttacgat cagattggtg ttttacaagc cttttcttat 435721 tgaaggatca tcaatggccc caacgcttaa agactcagaa agaattctgg ttgataaagc 435781 agtcaaatgg actggcgggt ttcacagagg agacatcata gtcattcatg acaaaaagag 435841 cggccgctca tttgtcaaac gtttaatcgg tttgcctggt gacagcatta aaatgaaaaa 435901 tgatcagcta tacataaatg ataaaaaggt ggaagaacca tacttaaagg aatataaaca 435961 ggaggtcaaa gagtcgggtg taaccttaac aggtgacttc gaagttgagg ttccttccgg 436021 taaatatttt gtgatgggag ataaccgtct caattcactg gatagcagaa acggaatggg 436081 catgccttct gaggacgata tcatcggtac tgaatctctc gtcttttatc cattcggtga 436141 gatgagacag gcaaaataaa atgcaatgca aaaagaacat ggaacatgac ggcaccgata 436201 ataaagcgcc gtgcacgttt aaaaaaatga tgatgaaacg gtgcggagcc ggctttccgc 436261 cccgtttttt atgatagaaa gcgttttgaa gaaaagggcc ctgttgaaat aaacagaatc 436321 aggattggcg aagccgtgaa gcgcatcgaa ttggtaaatc tcaagatggg tatgctgttt 436381 ttcccgcagt tttttgataa gaagcgctac gtcaaacgac ggctcataat tagggaaaaa 436441 caataggacc gggcaggctg gcatgtgatg aagagagtcg cgtatccggg aaccgtaata 436501 acaaaccgat ccgctcacct caggcatact gctgcatttc catgcgatag tagcccccac 436561 gctgaatcca atcacaaaga tgtgccgtcc ggcgttttgc ctgatcacat tctggatgat 436621 ggtttctccc gttttcagcc tttcgtgttt tgtaaattgt tcgtatgccg ttttttcttc 436681 tttcagtgtg tagacttcat cctcgccgag caggttgggc gtcaacacat catatccagc 436741 cattttgatc agccggccca tctttttcat atggctgttt acaccatata tttcgtgtgc 436801 gagaatgaca agcggttttg ggaacataac ggcctccttt tgtgtttttt ccattatatc 436861 ctatcgtttc actttaggct gagatataat ggtcaaaaaa aggagatata aaatgaactc 436921 attatctttg cctcaccgct atccattttt gtttattgat ggcgtgacgg atagcgagcc 436981 cggcaaacat gcggcagctt ataagctgat tagtgagaac gactggttta tcactgatac 437041 gcaaacagaa atgccgtttt cacttgtgat tgaagcgctt gcgcaaaccg cggcttttac 437101 aggaattaca gatgagaaca gcttgggatt attgtcttcg gtgaagaaag cggaaaagct 437161 gggagaagct gtgcctggtg accggcttga tcttacgttt gaagtcacgc gcaatcggcg 437221 cgggtttgtg ttcggacatg ccaaggcatc agttggagag cagcctgttg ctgaagctga 437281 aatcggcatc tatattgaaa aatgaaaaaa acccttcaca acattttgtg aggggttcta 437341 ttttgtgtcg taatcccgtt cgctttgaga gttatctctt tgctggcgtt tgtgtttttc 437401 atcattcata ttttccttca gctcttcatt aggaatcgga tcggttaagt cgttgtgctc 437461 ggggttttca tttggtttgt tttgctgttt tttttctgtc atgtttgatc acctcaccgt 437521 ttgttttcct cttattcatt ctcctcaaac ataggaaatc gcttttttgt cccgctgggt 437581 ataatgtatt agaatagaga gaagcacaac aaaaagataa agagaggtac atatatgtct 437641 gttcaaagag aagatgtaga tatcaagctg atcgcaattg atatggatgg tacactgctg 437701 aacgacgagc agctgatctc ggatgaaaac cgcaaagcca ttcgtgaagc ggaggataaa 437761 ggtgtgtatg tggtgatcag cacgggccgg acgctgatga cgtgcaggga gctggcggaa 437821 tcgctaaagc tgtcatcctt tctaatcacg gcaaacggca gtgaaatttg ggattcgaat 437881 tttaatttgg tggaacggaa gctgcttcat acggaccata ttcaaatgat gtgggatttg 437941 cggaataagc acaacactaa tttctgggct tctacggtga ataaagtatg gagaggcgag 438001 tttccggaaa acattacgga tcatgaatgg ctcaaattcg gctttgacat cgaggatgac 438061 gatatccgaa acgaagtgct tgaggagctg agaaaaaaca aagagctcga aatcacaaat 438121 tcaagtccga caaacattga agtcaacgcg cttggcatca acaaagctgc agcccttgcc 438181 aaggttacgg aaaaactcgg ctttacaatg gagaatgtga tggcgatggg cgacagcctt 438241 aatgacattg cgatgatcaa agaagcgggt cttggcgtcg caatgggcaa tgcgcaagac 438301 atcgtaaaag aaacggctga ttatatcacg gatacaaata ttgaggatgg tgtcgctaaa 438361 gcgattcgcc attgggtact ataaaaaaag agagtcctaa gatggactct cttttttagt 438421 ttggcaggtt ttattctggg accatggtag gttttctgac aaaagtattt cacaaactga 438481 tatgattcac ttataatgaa ataaagttca aaaattcgga atagtcgttc cgaatttcgg 438541 gacaataaat gacataaagc atatcgtttg ctttggcagg agggattctg tgtttcagat 438601 tgatttaaac tgtgatttag gagaaagctt cggagcctac aagataggcc ttgaccaaga 438661 tattttagag tatgtgacat cagcgaatat cgcatgcgga tttcatgcag gagatcctag 438721 tgttatgcga aaaaccgtcg cgcttgcagc agaaagaggc gtgaaaatgg gtgcgcatcc 438781 gggcttgccg gatttactcg gttttgggcg ccgcaatatg gcgatttctc ctgaggaagc 438841 gtatgatctt gtcgtttatc aaattggcgc gctctctggc tttctaaaag cagagggact 438901 tcacatgcag cacgtcaagc cgcatggcgc tttatacaat atggcggcag tcgatcaaaa 438961 actgtcggat gctatcgcga aagctgtcta taaggttgat cccggcctga ttcttttcgg 439021 tcttgctgag agcgagcttg taaaagcggg agaacggatc ggacttcaga ccgcaaatga 439081 agtgttcgcc gacagaacat accaatcgga cggcacgctg acaccgcgct cccagccgga 439141 cgcactcatt gaaagtgatg atgccgccgt cacccaggtc atcaaaatgg tgaaagaagg 439201 ggcggtcaaa tctcagcaag gacatgatgt gtcattaaaa gcagatacag tctgcattca 439261 tggagatgga gcccatgcgc tgacatttgc gcaaaaaatc agaaaacagc tcaaagcggc 439321 tggaattgaa gtgacagcta tttcagaaca gaggtcaaca taaaggagga acaatagatg 439381 gagcagcaga aaaagacagc aggaaaaaaa gcgggcagct ggtcattgct gatgggcgcc 439441 gcctttttaa tggcgacatc agcaatcgga ccgggtttcc tcacccaaac cgcaacattc 439501 acaaacacac tcgcagcaag cttcggtttt gtcatcttaa tctctattat tttagatatt 439561 ttcgcccaaa ccaatgtgtg gcgcatcatc gcagtttctg gaaaacgagg tcaggaaatt 439621 gcgaatatgg tgcttcccgg actggggtat ttcatcgcca ttctcgtcgt gcttggcgga 439681 ctagctttta atattgggaa tatcggaggg gccgggctgg gacttcaggt gctgttcggc 439741 attacacctg aaacaggcgc tttaatcagt gccgttatcg ccattttgat ttttgtcatc 439801 aaggaagcag gaaaagcgat ggaccgtttt acgcaaatcg cggggttcgt gatgattatt 439861 ttaacggtct acgttgcggc gacgacagct cctccggtcg gacaggcagt cgcaaataca 439921 ttcgtcccgg aacacatcag catatttgcc attgtcaccc tagtgggcgg aaccgtcggc 439981 ggttatatca catttgccgg aggacaccgt ttgcttgatg ccggaattaa aggaaaggaa 440041 tccattccgc aggtgacaaa gagctcggtt gtcggcattt taattacatc tgtcatgcgt 440101 atcgctcttt ttcttgcggt tctaggcgtt gtatcgaaag gcctgcacat cgatgaaagc 440161 aacccggcgg cttctgtctt caagctggct gctggaaatg tcggttataa aattttcgga 440221 ttgatcatgt ggtctgcggc gattacgtct gttattggag cagcctatac atctgtttca 440281 ttttttaaaa ccttttctcc aaaaattgaa aagaattcac gcggtattat tatcggattt 440341 attgtggttt ctacgttagc ttttgtcaca atcggccagc ctgcgaagat cctcgtcctt 440401 gtcggttcac tgaacggctt aattctgccg attgcgctcg gaacgctgct tgttgccgcc 440461 tacaagaaaa acattgtcgg tgattataag catccgcttt ggctgacaag cacaggcgcg 440521 cttgtagtga ttgtaatggc agttatggga atctacacgt tatgtacaca acttcctcaa 440581 ttgtggagct gatataagtg gagcaattaa acaaaatggc gccaaaggat gtacgcgccc 440641 tgatacgaga ggggaaaata aacgggccga ccgcaggcat gtccggcggc tacgcccaag 440701 cgaatcttgt ggttttgaaa aaggaccttg cgtttgattt tctgctgttt tgccagcgaa 440761 atcaaaagcc ctgccccgtg ctggatgtga ctgaagcagg ttcgcctgtg ccgtctctgg 440821 ctgcgccgga tgctgatatc agaacggact ttccgaaata ccgtatttac aggcacggta 440881 tcctaacgga agaagtatct gatattacgc catactggga ggacgatttt gtcggctttc 440941 tgatcggatg cagtttctcc tttgaacagg cactgatcaa taatgggata gctgtccggc 441001 atattgatga ggggacaaac gtctcaatgt ataaaacgaa tatcgattgt gttccggcgg 441061 gggcgtttca cggacagatg gttgtcagca tgaggccggt tcctgaacgg ctggctgtac 441121 gtgctgcaca agtgacctcg cgttttccgg ctgtgcacgg agggccgatc catattggca 441181 atccgggagc aatcgggatt cgcgatctcg ggaaaccgga tttcggagat gccgtttcca 441241 ttcgtgacgg cgaggttcct gttttttggg catgcggagt gaccccgcaa gccgtggcta 441301 tgaatgtaaa gcctgaaatg gtcatcacac atgcgccggg gcatatgctc atcacagata 441361 ttcgagacga gtcgcttgcg gtgctgtagc ctctcgtcat cctgatgaac gagaattaaa 441421 agaggtgaga aagatgactg tacgatatca aatcgaacag ctcggtgatt ctgcaatgat 441481 gatccgattc ggagaagaaa tcaatgaaca ggtcaacggc attgtccatg cagcggccgc 441541 ttatatagaa gaacagccat ttccgggatt cattgaatgt atcccggctt ttacaagtct 441601 aaccgtattt tatgatatgt atgaagtgta caagcatttg cctcaaggca taagctcacc 441661 ttttgagagt gtcaagcgcg atgtcgaaga gcggctggca gaaatagccg aagactatga 441721 ggtcaaccgc cgtattgtag aaattcccgt ttgctatggc ggtgaattcg gtccggattt 441781 agaagaggtg gcgaagatca atcaactgtc accggaggaa gtaatcgaca ttcatacaaa 441841 cggtgaatat gtggtgtata tgcttggctt cgcgcccggt tttccttttc taggcgggat 441901 gtcaaaacgc attgcagctc cgagaaaatc atcgccaaga ccgtcgattc ccgcaggttc 441961 ggtcggtatt gcgggattgc agacaggcgt ttatccgatt tcaacgccgg gcggctggca 442021 gctgatcggc aaaacgccgc tggctctttt ccggccgcag gaaaacccgc cgacattgct 442081 gcgggcggga gatattgtga aattcgttcg catctcagaa aaagactatc acgcctataa 442141 ggaggagtcc aattgagcat gaaagtatta aagcccggac tgctcacaac ggttcaggat 442201 ataggcagaa cgggttacca aaaatacggc gttctggcca gcggcgctat ggacacggtt 442261 tcactgcgca ttgccaatct gttgatagga aacggcgaaa atgaagcagg tctcgaaata 442321 acgatgatgg ggcccggtcc gtcgtttcat ttttcaaaac agacactgat tgctgtgaca 442381 ggggcggact tcacgctgcg tattaatgac gaggaagcgc ctttatggaa gcctgtgctc 442441 atcaaggaaa acagcacggt cagctttggc ccctgcaaac tcggcagccg tgcttatttg 442501 gcggcagctg gcggcattga ggtgcctgcc gtcatggaaa gtaaaagcac atacgtcaga 442561 ggaagcattg gcggacttca tggcagagcg cttcaaaaag aagatgaact gaacattgga 442621 gagatgtcag ctctttcgca aaccatcctt tctcgcttaa gttcgcagct tggaaaacag 442681 ggatttgcag caccgaagtg gtcagtcagc cgcggcagat ttctgccatt gaagaagaat 442741 cccgtcattc gggtgctgga aggaaagcaa tttgcctttt tcacagaaga atcaaaaacg 442801 cgtttttatg aagaagcatt tcgtgtcacg ccgcagtccg accgtatggg ctacaggctc 442861 aaaggagaac cgctcgaact gaaggccccg cttgagatgg tgtcggaagc ggtttcattc 442921 ggaacagttc aggtgccgcc tgacggcaac ccgattatcc tgcttgcaga ccggcagacg 442981 actggcggct atccgaggat cgcgcacatc atatccgctg atcttccgat tgtttcccaa 443041 atcatgccgg gcgagcacgt tcagtttgag cctgtgtccc tccaggaggc agaagcgctt 443101 gcggtagaac gggaacagca tataaaagaa ctgaaaacga gaatgaagat ggaatggctg 443161 acatagcaaa ggggatgaat gatgcagaat aaaaataaaa ccgtagtcaa atctatggcg 443221 ctgcttaatt tgtttttgca taaaccaagc ctaaccttaa gtgaactggt gtcgctgacg 443281 ggaatgccga agacctctgt tcaccggatg gtcagctcct tggaggaaat ggggttcctc 443341 agtcgggatg cgtccggcgc ttattcgctg ggattggtgt ttttggaatt cggacagctt 443401 gtcgctgaca ggctggatat cagaaaaata gcgaaaccgg tgatggaaga gctgtgccgg 443461 gaagtggatg aggccgtgca gttgatcatg agggacggca atgaagcgat atacgttgag 443521 aaaatagaag ggacacagac tgtgcggctg tatacggcga tcggcaggcg ttccccccta 443581 tacgcgggag cgtgcgccag aagcattctg tcctttcttc cccgtgaaga aatcgaagca 443641 tacatcaaac aaaccgagct catttcgatt ggctccggaa cgattaccga tcccgaaaaa 443701 ctgcttcagg agattgatgc ctctgtgcaa aatggctata ctgtcagcta ttcagagctc 443761 gaaaactata cggcggcgat cggcgccccg atctttaacc atgagcgcca ggtggcagcc 443821 ggcattagca ttgcaggctt tgaagcgaga tttacagaag acaggctgcc ctatttaaca 443881 gaaaaggtga aggacgccgc tttacagatt tcaagaaaaa taggatatac ataagtagcc 443941 aatcttttct ctgctgcgta cattaacgta tcgacgttca agagtggagg aaagaacatg 444001 gtgcttcgat atacagctct gggcgattcc ttgacgacag ggagaggctc cgggctgttt 444061 tcacccggct tcgtccagcg ttttggggac atgatggaag ctgacttgaa aacaagaacg 444121 gcaataaaca tatttgccag atcaggtctg aatacagaag agattttggg actcctgtca 444181 tatccctatg tgcaaaaatg tattcgagat gctgatatga taacgatcac agggtgcgga 444241 aacgatctca tcgattcggt cttagcctac caaacctcta aggatgaaac gattttcagc 444301 cgtgtatccg cccattgcca tgagaatttt gaaaagatga ttgccaaagt cgccgagatt 444361 aaaggagaaa atccttcccc gtacgccatt cgtgtgttca acttatacaa tccgtttccc 444421 gaaattgata tcgccggcaa atggatcact tcgtttaatt cacatttaga aacacttgca 444481 tcagcacccc atgtcaaaat cgcggatgcc tatagcatct tcaaaggcaa agaacaggaa 444541 tatctgtcct ttgacggtgt ccatccgaac agcaaaggct atcaagcgat ggctgaagcc 444601 gttcacaagc taggctataa agaattatca gtttcataga aaacgcgcct catgacaggc 444661 gcgtttttta tgtgtgatcg aaatattaaa agaaacttaa aattctctgt cttctgttct 444721 acagacaaac aaagtgcgct agaataatgg agggcgtagg caaatatagc cataacgttc 444781 aatatttcgt atataaggaa ggatggtcct tttgtttcgg atttttaaaa tgtcttttgc 444841 ggttatcatt attatactgg cgcttattgc ttttaactat acggaacaca cctctgtaat 444901 ccaatcggtc atgctcgtct ttcttggtgc ggtcatgttt atgcaggggc ttgaagagcg 444961 caaaaaagaa aatgacggct caggcgcttt taatatttat accgccgttt ttgtatggtc 445021 tgtctccctt atcggtttta cacttcatat tatataaatc tattacacat cctgaaaatg 445081 ctcgaccgtc gggaacgggg tatagaaccg atgaagcaag gctttccact cttgatactc 445141 tgaagaaccg cgaaagcctt ccgtatggtc ctcaagtgtt tcccactcca caagaagcag 445201 atatttatgc gtttcctcca tgcattttga taacgagtga gtgatatagc ccttcatgcc 445261 ggaaataatc ggcgcagctt gccggaatgc atcctcaaac tcttgttcaa ggccttcttt 445321 aatgtgaagc attgctgcct ctctgaccat gctatccctt ctttctgtct tttcaaatag 445381 tctacagcaa acgataggag atttctgcaa aatcggtgaa cttttccttc attttcaaaa 445441 aaatcttgca cgcaccaatt caattaagag aaaataacaa gtggaaggca ggggaaagtc 445501 atgttaaaaa agtgtattct actagtattt ctatgcgtcg gattgattgg gttaatcgga 445561 tgctccaaaa cagattcacc agaggatcgc atggaagcat tcgtgaaaca gtggaacgat 445621 cagcaattcg atgacatgta tcaaagcctg actaaagatg tcaaaaaaga aatctccaaa 445681 aaagatttcg tcaacaggta taaagccatc tatgagcagg ccggcgtaaa aaatttgaaa 445741 gtcactgcgg gagaagtaga taaggacgat caagacaaca agacgatgaa acatatcccg 445801 tataaagtca gcatgaacac aaatgccggc aaagtcagct tcaagaatac tgctgtgctg 445861 aaattagaaa aaacagatga cgaggagtca tggaatatag attgggaccc atcgtttatt 445921 ttcaagcagc tggctgacga caaaaccgtg caaattatga gcattgaacc gaaacgaggc 445981 caaatttacg ataaaaatgg aaaaggctta gccgtcaata cagatgttcc ggaaattgga 446041 attgttcccg gagagcttgg cgataaaaaa gagaaagtca taaaagaact cgccaaaaaa 446101 cttgatttga ctgaagacga catcaagaaa aagctggatc aaggctgggt aaaagacgat 446161 tcgtttgtgc cgctcaaaaa ggtcaagcct gaccaggaga aattagtttc tgaagcgacg 446221 tcattacaag gcgtaacaag aacgaatgtc agctcccgct actatccgta tggcgaaaag 446281 acagcccatt tgacaggcta tgtccgcgcc attacagcgg aagaactgaa gaaaaagaaa 446341 gaaggaacgt acagcgatac gtctaacatc ggtatcgccg gacttgaaaa tgtgtatgaa 446401 gacaagctaa gaggcacaac tggctggaaa atctacgtgc cgcaaaccgg ggaagtcatc 446461 gctgaaaaga aagcaaagga cggcgaggat cttcacctca caattgatat caaaacgcaa 446521 atgaagctgt atgatgaact gaaggatgac agcggggcgg cagtcgcgct gcagccgaag 446581 acaggcgaaa cactcgccct tgtcagcgcg ccttcctacg atccaaacgg atttattttc 446641 ggctggagcg ataaggaatg gaaaaagcta aacaaagata aaaacaatcc gttttcagcg 446701 aaattcaata agacatacgc gccaggttct accattaaac cgattgcggc tgctattgga 446761 atcaaaaacg gcacccttaa agccgatgag aagaaaacaa tcaaaggcaa ggagtggcaa 446821 aaagattcaa gctggggcgg ctattcagtg acacgtgtgt ctgagagact tcaacaagtc 446881 gatttggaaa acgcccttat tacgtcagac aatatttatt ttgcccagaa tgcgcttgat 446941 atgggagcgg acacctttac aaaaggcttg aagacattcg gtttttcaga ggacgttccg 447001 tacgaattcc cgatccagaa atcgtctatt gcaaatgaca agcttgattc agacattttg 447061 cttgcggata caggctacgg acaagggcaa atgcaaatgt ctccgcttca cttggcaact 447121 gcttacacgc catttgttga caatggagac cttgtcaaac cgacgctgat caaaaaagat 447181 tcacaaacag ctgatgtttg gcacaagcaa gtggtcacga aggaaggagc ggcagacatt 447241 acaaaaggtc tgaaaggcgt tgtggaagat gagcgcggat cagcgtatca gcctgtcgtg 447301 aaaggaatca cagtggctgg aaaaacagga acagccgagc tgaaaacatc aaaagatgat 447361 aaagacggca cggaaaatgg ctggtttgtc ggctacgatt acgaaaacaa agacctgctt 447421 gtcgccatga tgatccaaaa tgtgcaggac cgcggcggca gccactatgt cgttgagaaa 447481 gcgaaaaagc aatttcaatc gaattaaaat gtctttttaa aaggagcgaa aggaaaaagg 447541 ggatctgagg ccgaatgaac tagtaagggg gcaaaacccg gtttatacaa agaaaagagg 447601 gattttgcat gcagcgtatt caattggcgg aggatcttca attttcaaga gtcatacacg 447661 ggctttggcg gctgaatgaa tggaactatt cagatgctga acttctaagc ctcattgaat 447721 ggtgtatcga tcacggcatc acgacctttg atcatgcgga tatttatgga ggctatacgt 447781 gcgaaaagct gtttggaaac gcccttgccc tttcgcctgg attaagagaa aacatagagt 447841 tggtcacaaa atgcggtatc gttcttgaat cgcctgaacg gcccgctcac agatcgcatc 447901 attataacac aagcaaatcg catattttgg catccgttga gcaatcgctt atgaacctta 447961 ggacggatta tatcgatatg cttttgattc acagaccgga cccgctcatg gatccggagg 448021 gggtagcaga ggcgtttcag gccttgaaat gctctggcaa ggtcaggtac tttggcgttt 448081 caaattttaa agatcaccag tatcggatgc tggaatcata tttgcctgag aagctcgtaa 448141 ccaaccagat tgagctttcc gcatacgaat tagaaaatat gctcgacggc actttgaacc 448201 tgtgccagga aaaacggatt ccgccgatgg cttggtcgcc tctggcaggc ggcaaagtat 448261 tcactgaaaa cacggataaa gaccgacgtg tccgtacggc gcttgaatcc gtccaagggg 448321 aaatcggcgc cgcttcattg gacgaggtga tgtacgcatg gctgtatacg catccggccg 448381 gcatcatgcc gattgtcgga agcggaaagc gcgagcggat ttccgccgcg ataaatgcgt 448441 tgtcatacaa gcttgaccag gatcaatggt tccgcatttt tacagccgta cagggttacg 448501 atattccata aaaagcatca gtttaccagc tgatgctttt tcaatattgt cacaccgctt 448561 agtgccaaat taccatttat aagtgattga ttctttcttg aaagcgtttt atattaaaag 448621 gaaacctctc tatatcctct actgcatctc cttgcgactt catccgcaca tcaagattgg 448681 ctaggaggtc ttttttatgt atatgactgc cagagaacaa aagctgttaa agcacttatt 448741 attacaaaac agatatataa ccgtaactga gcttgctgag ctgatgcaag tcagcacgag 448801 aaccattcac agggaactca aatcaattaa accgctgatg gaaaccgtgg ggcttacgtt 448861 agataaacag cccggtaaag ggttgaaagc agtgggaagt cccgagggta aacaaaagct 448921 gcttactgat ttatcatatg aacagcatga atacagcgcc gacgaacgga aactgctcat 448981 tctttgttcg ttattagagt ctcaggagcc cgtcaaactg tacacgcttg ctcatgatct 449041 ccaggtgacg aatgccacgg tcagctatga cttagatgag ctcgagaagt ggatttctcc 449101 ctttggactg acactgatcc gcaaaagagg ttttggcatc cagctcatag ggccggagaa 449161 tgcgaaacgg aaaattgtcg gcaacttgat tgtgaaccgt ctcgacatcc aaatgttttt 449221 ggaagcggtt gaattaaaca tcaaaggaaa aaccgattct tcagagaaaa tgttcggggt 449281 tgtcagcaaa ggtgagctgt taaaaatgga gcgcatctta tttcagctca aagaaaaaat 449341 cgctttttca ttgtccgaca gctcctatat agcgctcgtc gtccatctga cgtatgcgat 449401 cgaacgaatt aagcttgggg aaactatcac catggagcaa aatgagcttg aggaactgat 449461 gaatgcgaag gaatacagct ccgctcttga aatcgcgggc gagcttgaac gtgccttcgg 449521 cgtgacgatt ccagaggcgg aggtcggcta tattacaatc catcttcgaa gcgccaatcg 449581 aaaatacaaa acagaataca aagcgcagga aattgagctg gaaacagccc tgcaaacaaa 449641 gcggctcatt gcttttattt cagacaaaat cagaatggat ctgacgaaaa actactcttt 449701 atatgaaggc ttgattgccc atttggagcc ggccgtcagc cgcataaaag aaaatattga 449761 gatatacaat ccgatgaagg aacagatcaa gcgcgattat tttctgcttt atatggcgat 449821 cgaagaaggt gtcgaaaagt attttccggg catgtccttt tctgatgatg aaatcgcttt 449881 tatcgttctt cactttggct cggctcttga aatcaaaaaa gaagaagcaa aagtgaaagc 449941 gcttgtcgtc tgctcaagcg ggatcggctc ctcgaaaatg cttgcctcca gactgaaaaa 450001 agagctgccg gaaattgaat cgtttgatat gtcatctctg atcgagctaa aggggaagga 450061 tgttcaagcc tatgatatga ttgtgtccac tgtaccgatt ccttatgaaa acattgatta 450121 catcatggtc agcccactat taaatgagga agacgcaaac caggtcaagc agtatatcaa 450181 gcggaagatt ccccttattc ttaacaaaaa aagaagctcg aaggaagagg cgcagcaagc 450241 tgatgtacct gacatgctgg aggcggcgga aagcataggg cggtatatgg aagttatcca 450301 agatgttctg cgccatttta cgctagctca actcaaaaca aacccggacc atagcatgct 450361 tctgctagag ctttttcaac agctgaagaa ggatggcctg atccgtgatc cggaaaaagc 450421 cgcggtttgc ctggctgagc gggagaaaca agggggattg ggaatccccg gaacaaacat 450481 ggcgctttat catctcaaaa atgatgaaat cgtcctgcct tttttcaaaa tgtttgatct 450541 cagcaccccc tatgaagtgg atggcatgga cggaaatacc ctcaggatga cacgcattct 450601 cgtcatgatg gcgcctggct cattatctgc tgaaggctcg gagattttaa gcgcgatcag 450661 ctcggcaatt atcgagagcg gagaaagcat ggcggggttt caggaagaag gaggacaaga 450721 attgtatcag cggttaaacc gcatattttt cacatggatg aaagaaaaaa acatactgta 450781 aacctgcatg gcacacgtca aaaatttggc gtgtgttttt ctgtggatgg ggaacaaaat 450841 aagaaaatgt gggactattt tatcattcag tattggaata attccaaaat gaaatagttt 450901 tacaagttat cttttttggg ttaaaatggg tgaggtaagg aagaaaatct aacaaattat 450961 tgaagattca agagaatata ggagatgacg atatggaaac attacagcat ctgattctgc 451021 atgacatgcc gaatagcgaa gaaatagagg ctgtaaaaag cggagaccat acactgacat 451081 ataaaggtta ccgtaaacgg attaatcagc tggcgaatgc catgcttcaa aaaggaattc 451141 aaaagggcga ccgtgttgca ttgctttgca aaaacggcca tcccgcctca actgttatgt 451201 tcgccgcact tgaaataggt gctgttgtcg tacctgtcag ctggcagctg aaaccatatg 451261 aaatgacagg cattttaaaa gcaagtgaac caaaagcgat gttttacgga gcggagttta 451321 aagagatact ggatgaagtt cttcctgaat tgtcctcact gtgtgtaaca atggaaacag 451381 gaacagctta cgaaacatct gctgaatttg aagcgctgtt tgcaggtcct gatcatttgc 451441 cagagacgga aatggtttca cctgatgata cagcacttct gatgtttaca tctggaacaa 451501 cgggaaaccc gaaaagatgc atgattacac atggcggcat atacagatac gttaaaaaat 451561 ccaacagctc aatagcacgt atgaagggcc ttcgttttct cgcgtgccat ccgatttatc 451621 atacgagtgc gctcatttgc atcatgcttg gaacgtttgc agaaacaaca tttgtgttta 451681 caaaggatca agatcctgtt cacatgctga aggtcattga agaagagaag attcagaccg 451741 tgatggctct tcctgtgttc tacacgtatt tgcttgaggc gtgggaaaag caccaaactg 451801 acttatcttc gcttgttatt ttaatgacag gcggaacaaa agtgccgagc agcctaataa 451861 gccgctatct tgatattggc attccgcttg cgcatggcta tggaagtact gaggcttggg 451921 gcatcagcac atggacgcct gatatgggaa tggataaagc ggcatctgca ggaaaacctg 451981 tggcaggtgt taaagtcaaa gtggaagatc ctctgaccgg agaagaactt cctcaaggag 452041 aaatcggcga aatcgttgtt catactccat tcttatttaa aggctatgaa gacaatcctg 452101 aagcaacagc gaaagtgctg caaaatggat ggtttagaac cggagattca ggatatgtag 452161 atgaagatgg ctttattttc atcacgggac gctacaagga tgtcattatt tacggaggcg 452221 ataacgtcta tcctgatcag gttgaagaag ttatccagca gatcccggga atccttgaaa 452281 cggctgtggt cggtattcct gacccgcttt acggtgaaaa accgaaagct tttatcgtga 452341 aaaatggcgg ccagcgcatc acggaagagg atgtcatcgc attttgtaaa gaacgcctgt 452401 ccgcttacaa aatacctgaa gttgaatttg ttaacgaact gccgaaaaac aaccttggca 452461 aggtgaaaaa agacgtcctg cgcaatcagg ctgtacattc ataaaagaag aagcccgtcc 452521 actttatgtg gcgggcttct ttgcagttgc acagacggaa agctcaggct taatgttctt 452581 aaattgtata tcaatgtctt cgaagccggc tgctttaaag tcagcaatca tctgtcttcc 452641 aaatgatttg gttttctcag gactggcatc cgcttcccgc ggctgcatcg taatggctgc 452701 tttgccgcct ggctttaatg cccgataaat ctgttttatg ccttttgttt ggtcattcca 452761 aatggtgtag ttgttaacgg aaatcacttt atcataaaac gaggcgggga gaggaaatgt 452821 ctcgatgctt ccttgtatca ggcgtacgcc ctttggtttc actctgcggg cggccagctt 452881 cagcatggcc tctgatacat caatcccatg aagatgaaca tccttctcgc gtttcagcat 452941 ctgctgcatg cagtatcccg ggccaaaccc gacttctaaa atgctgtccc cgcgcgtgat 453001 acccagctga ttgattgtcc actgattcag tgtttgattt tcagcagcca tgatgtaccc 453061 ggcaatcatg ccgatgacgc cctttggcct gctgaatctt ctagaaagca tgttaatcat 453121 tcagcaacca accccctttt tgagttaatt tcctctcagc gttccatgtg aaacattttt 453181 ctgataaagc aatgcgaagg tgccaagcca tgtttatcca aagagtgtgt gaggtacaca 453241 acaaatagac atgaaaacaa aggaggagaa tcatcatggc aaattatcca aaagaactgc 453301 cggcacaaac tcaaagtcgc cagccgggaa ttgaaagcga aatgaatcca agtccggtgt 453361 atgagtacga ggattataaa ggagcagaca aattaaaagg aaaagtagct cttattacag 453421 gcggcgacag cgggatcgga cgcgcggttt ccgtcgctta cgcaaaggaa ggcgcagaca 453481 tcgccattgt gtataaggat gagcatgaag acgctgagga gacgaagaaa cgtgttgaac 453541 aagaaggcgt aaaatgcctg ctgattgctg gtgacgtagg tgaagaggaa ttctgcaatg 453601 aagcggttga aaaaacggtc aaggaactag gcggccttga catccttgtc aacaatgcag 453661 gtgaacagca cccgaaggaa agcatcaaag atattacgag cgaacagctt caccgcacat 453721 tcaaaacaaa tttttattct caattttatt tgactaaaaa agcaattgat tacctgaaac 453781 cgggcagcgc catcatcaat acgacatcca tcaacccgta cgtagggaac ccgacactga 453841 ttgattatac agcgacaaaa ggggcgatca atgcctttac aagaacaatg gcgcaggcgc 453901 ttgtcaaaga cggcatccgt gtaaatgcag tcgcgccggg tccaatttgg acgccactaa 453961 tcccagctac gttccctgaa gaaacagttg ctcaatttgg gcaagatacg ccgatgggcc 454021 gtcctggaca gcctgttgag cacgtcggct gttatgtgct tctggcatca gatgagtcct 454081 cttacatgac aggtcagacc ctgcatgtca acggcggaaa ctttgtgacg acataagagg 454141 gagtgagaca tatgggcatc acgaaagaag aagtgaacag ctactatcaa aaagcaggga 454201 ttgtattaac ggacgaggaa gtagaccaaa tccagctgat ggattacggc ttaggaaaag 454261 aaagaaaagt cgggctccag ctcttcgtct acgtcaatac agaccgttat tgttcaaagg 454321 aattggtgct gtttccggga cagacttgcc cggaacaccg ccatccaccg gtcgacggcc 454381 aggaaggcaa gcaggagacc ttccgctgcc gctacggaaa agtgtatctt tacgtagaag 454441 gagaaaaaac gccgcttcca aaagttctcc ctcctcagga agacagagaa cactatacgg 454501 tctggcacga aattgagcta gaaccgggcg ggcaatacac gattccacca aacacaaagc 454561 attggttcca ggccggggaa gaaggtgccg tcgtgacgga aatgtcatcg acgagcacgg 454621 ataaacatga tatctttacc gatccaagaa tataaggatg ggcttaacag cccatccttt 454681 ttgtattgaa aaaaacagaa tcatcgctat aatgggtaaa aaaggaaaga gggcgaggca 454741 atgttcactt gcaaggtaaa tgagcacatc accatccgat tattggagcc gaaggatgcg 454801 gagcggctgg ccgaactcat tatccaaaat cagcagcggc ttggcaagtg gctgtttttt 454861 gcggaaaatc caagcagcgc tgacacgtac cgagaaacaa tcattccaga ttggcggcgc 454921 cagtatgccg acctgaacgg cattgaggcg ggtctccttt atgacggcag cctatgcggc 454981 atgatcagcc tgcataacct tgatcaagtg aatcgtaagg cggaaatcgg atattggatt 455041 gccaaagaat ttgaagggaa aggcattatt acagctgcct gccgaaaact cattacgtat 455101 gcttttgaag agcttgagct gaatcgtgtg gcgatctgtg cggctgtcgg aaacgaaaaa 455161 agcagagcgg ttccggagcg gatcgggttt ctagaggaag gaaaggcacg ggatggctta 455221 tacgtaaacg gcatgcatca cgacctcgtc tactacagtc tgttaaagcg tgaatgggaa 455281 ggcgaaaaat aaagagcaca ctttcttgtt taaatcttcc ccggatgtgg aaaagtaaca 455341 gcggagacgt taaaaaggag tgattcgaga tgaatcagca agacattaaa caaaaagtgc 455401 ttgatgttct agatcaccat aaagtaggtt cgctcgcaac agttcaaaag ggcaaaccgc 455461 attcccgcta catgactttt ttccatgacg ggctgacgat ttacacaccg acaagcaagg 455521 aaactcataa agcggaagaa attgagaaca accccaatgt ccacatttta ttaggctatg 455581 attgtgaagg ttttggcgac gcatatgtcg aagttgccgg aaaagcaaag atcaacaatt 455641 cggcagaact caaggacaaa atatggagtt ccaaattaga gcgctggttt gacggcaagg 455701 atgatccgaa tctggtgatt cttgaaattg aaccggagga tatcagatta atgaatgccg 455761 gggagaaaac accggtctca ctcgaactat aaaaaatttg tgttttcagg ggcgatatgt 455821 tattatgaat agctagtaag aaaaataagc aaataaaaaa gaaagtaaac ttcttttttc 455881 tgttttgaga gagaagctta ccgcttccca agcagcataa ccagctgccc ttattctttt 455941 ccttcataac aaatcgcccc taacgatgag atggaaaaaa gacttttttg ttttacaatt 456001 cacaccggcg cggcttcgga gccgcagtga cgattgagag gtagggcttt cgttgtcttg 456061 tgttcaagaa atttccatgg tgtttacttt ccagaatgat tcttcggaac aatgctttat 456121 gaatctaacc cgcctgactt ggcggatgat ataatcttta tttgcgtata gaaaagaata 456181 agacaaaccg cccggcgtac gccggacggt ttttttattg caaaaaacac atcgtactga 456241 aacctccttg tcttctttcc agtcttatct ctaggatgaa attggaggaa gaataacgtg 456301 catgtcatta caacacaagt actttttatt ttttgttttt tattgctgat tcactcgata 456361 gaaaccttag cctatgcgac aaggctttcc ggagctcgcg ttggatttat tgcgtccgcg 456421 ctttctctgt ttaatgtcat ggtcatcgta tccagaatgt cgaatatggt gcagcagccc 456481 tttactgggc atttaattga tgatgctgga aaaaacgcac tggcgattgt aggggagcag 456541 ttccgctttt taattttcgg atcgacagtc ggcaccattt tgggcattat cctgctcccg 456601 tcttttgtcg ctcttttttc acgggcgatt attcacttgg cgggcggcgg cggctccgtt 456661 tttcaagtat tccgaaaggg attctcgaaa caaggattca aaaatgccct ttcctatttg 456721 cgtctgccgt ccatttcata tgtaaaagga tttcatatgc gcttgattcc gaagcgtttg 456781 tttgtcatca acatgctgat cacatcgatt tatacgattg gtgtgctttc ggctttatac 456841 gcaggccttt tggcgccgga gcgcagcacg acagccgtca tggcttcggg tttgatcaac 456901 ggaattgcaa cgatgctgct ggctattttt gttgatccta aggtatccgt tcttgctgat 456961 gatgtggcaa aaggaaaacg aagctatatc tatttaaaat ggacctctgt cacaatggtc 457021 acatcaaggg tggcgggcac actcctcgcc cagctcatgt ttattcccgg ggcctactat 457081 atcgcgtggc tgacaaagtg gttttaataa gaaaggctgg atcataaaga tccagccttt 457141 ttgcgcttcc ttatttatag ttccttaatc cgcggtcgta caaaaaattt ccgaatggga 457201 cgaaagcggc gatgaagccg gcagctgacc atttcagcgg ccatttgaca gagaaggttg 457261 cataagccaa gacaagcaaa tacaaaatga acaacccgcc gtgaaccgaa ccgacaattg 457321 tcaccgcaag cggaaggcct gcccaatatt taagcggcat agcgatgaac aacaggatta 457381 agagtgacat tccttcaata aaacccatcg tgcgaagtct tccgatcggc gtgtgcagca 457441 taaatcgccc tccttgtgga cacgttttca ttttatacta taaacaatcc gggggggcat 457501 atgacagctt tcaaaaaatg ttcggaaaac attcattttt acatgccttt tctagggaac 457561 tgtacttgtc atttacaaaa atacccgaga taatgtgtac aaaatcaaaa aagaaggatg 457621 ttgaaatgaa acttgaccag attgatctga atatcattga ggagctgaag aaggacagcc 457681 gtttgtcgat gagggaatta ggcagaaaaa ttaagctgtc gcctccatct gtaacagaac 457741 gggtaagaca gcttgaatcg tttggcatca tcaagcaata cacgctggag gtcgaccaga 457801 aaaaactggg gcttcccgtt tcctgcattg tggaagcaac cgttaaaaac gcggattatg 457861 agcggttcaa aagctatatt caaacattgc cgaatattga attttgctac cggattgcgg 457921 gtgcagcctg ctatatgctg aaaatcaatg ccgaaagcct cgaagcggta gaagatttca 457981 ttaacaaaac atcgccctac gcgcaaaccg tcactcacgt cattttctca gaaattgaca 458041 cgaaaaacgg gcgcggttag agagtgccgc gcgaagtctg ttataataac aggatgagcg 458101 tgaaagaaag agaagtgatc aagcatgtca aaaacagttg tattagctga aaaaccttca 458161 gtcggccggg atttagcccg ggtactgaag tgccataaaa aaggaaacgg ttatctcgaa 458221 ggcgatcaat atattgtgac ttgggcttta ggccatttgg tgacgcttgc tgatccggaa 458281 ggctacggaa aagaatttca atcatggcgc ctagaggatc tgccgattat cccagaaccc 458341 ttgaagcttg tggtgataaa aaaaaccgga aagcagttca atgcagtcaa atcccagctt 458401 acccgtaaag acgtcaatca gattgtcatc gcgactgacg caggccggga aggtgagctt 458461 gttgcgcgct ggatcattga gaaagcgaat gtccgaaaac caatcaagcg gctgtggatt 458521 tcatctgtga cggataaagc gatcaaggaa ggttttcaaa agctgcgcag cggcaaagaa 458581 tatgaaaacc tgtaccattc tgccgtcgcc agagcggaag cggattggat tgtggggatc 458641 aacgccaccc gtgcacttac cacaaaattc aatgcccagc tctcatgcgg gcgtgtgcag 458701 actccgacgc ttgccatgat tgcaaagcgc gaggcagaca ttcaggcgtt tacgcccgtt 458761 ccgtattacg gcatacgtgc tgcagtcgac ggcatgacgc tgacgtggca ggataagaaa 458821 tcaaagcaga cgagaacgtt caatcaagat gtaacaagcc gtttgctaaa aaatctccaa 458881 ggaaagcaag cggtcgtagc tgagctgaaa aaaacagcga aaaaaagctt tgcgcctgcg 458941 ctttatgatt taacggagct ccagcgtgac gcccacaagc gcttcggttt ttctgccaaa 459001 gaaacgcttt ctgtcctgca gaagctatat gagcagcata agctcgtcac atatccgcgg 459061 acggactcta gatttttatc cagtgacatc gtcccgacgt taaaagaccg tctggaaggc 459121 atggaagtaa aaccgtatgc ccaatatgtc agccaaatta aaaaacgcgg cattaaatct 459181 cataaaggat atgtcaatga cgcgaaggtg tcagaccacc acgcgattat cccgaccgaa 459241 gagccgctcg ttctcagcag tctgagtgat aaagaacgaa agctgtatga cctgattgcg 459301 aaacgtttcc tggctgtatt aatgcctgca ttcgaatatg aggaaacaaa ggtcatcgca 459361 gaaatcggcg gagaaacctt tacggcgaaa ggcaaaaccg tgcagtcgca agggtggaaa 459421 gccgtttatg atatggcgga agaggatgat gagcaggagg atgacagaga tcagacactt 459481 cctgcgcttc aaaaaggcga cacacttgcc gtccgcacgt taacggaaac aagcggccaa 459541 acgaagccgc ctgcccgctt taatgaaggg accttgctgt cagcgatgga aaacccaagc 459601 gcgtttatgc agggagaaga aaaaggcctc gtcaaaacgc ttggagaaac aggcggcctc 459661 ggcacggtgg caacgcgtgc cgacattatt gaaaaactgt tcaacagctt tttaatcgag 459721 aaaaaaggcc aagatatttt tatcacatct aaaggaaaac agctcctgca gcttgttccg 459781 gaggatctga aatcaccggc cttaacagca gaatgggagc aaaagctgtc tgcgatcgcg 459841 gccggcaaat tgaaatcggc tgtttttatt aaagatatga aggcttacgc tcaccaaacg 459901 gtaaaagaaa tcaaaaacag cagccaaacc ttccgacatg acaacattac gggaacggca 459961 tgtccggaat gcggcaaaat gatgctgaaa gtaaacggca aacgcgggac gatgctcgtg 460021 tgccaagatc gtgaatgcgg aagcagaaaa acgattgccc gaaaaacaaa cgcacgctgc 460081 ccaaattgcc ataaaagaat ggagcttcgc ggccaaggcg agggccaaac ctttgcgtgt 460141 gtgtgcggtc accgtgaaaa gctctctgta tttgaaaaac gaaaaaacaa agacaaagcg 460201 cgtgctacca aacgggacgt atcctcttat atgaaaaaac aaaataaaga tgagccgatt 460261 aacaacgcgc tggcagaaca gctgaaaaaa ctcggtttgg ataaataata aaaaaacctg 460321 tgcctatcgc acaggttttt tattggactt aggtcctgtt ttcttaatgt tcaaaaaggg 460381 aaaaaaaagc tagcaatctg catttttttt cttttatagt aaatgtactt tgtaacatgg 460441 cagtcatatt ttcgtctata actatttgtg agcgtctgat ttgcttcagg cgacaaaggg 460501 ggatttgcct gtgaggcatg tactaattgc tgtcatctta ttcttcttat ctatcggact 460561 ttccgcaggg tgtgctgaag ctggaaacaa gacccaaaat cagtcggcga cagaagtgaa 460621 tgccagcccg ctccagccgg cggaatattt catctatcac aatttaatga atgacaaagg 460681 gctgatcaaa accgattttt cagaccagcc ttcttacttg tcggaatctc tcggactgtg 460741 gatggagttt ctgctcagca aaaatgacgc accacatttc caggatcaat atcagcatct 460801 gactgattca tttctgatga gcaatcactt ggtgacgtgg aagattcaaa atggccaagc 460861 gagcgggacg aatgcgctga tagatgatat gagaattatg ctgtctcttg accaagccgc 460921 cgcaaaatgg ggccgcagcg actacgcgca aacggctagg gatatcggca cgtctttgaa 460981 gacatacaat atgaacaacg ggttttttac agacttttac gactcacagg ccgcttcaaa 461041 ggatgtgacg ctttcatacg tcatgcctga tgccttagct gtcttaaaga agaatggaat 461101 catagacgaa gaaacagaac agcggaatgc caatgttctc tattcagctc ctttaaaaaa 461161 tggctttctg ccgaagacat acagctcgga gacgaaggaa tacacatatg atagtgaaat 461221 caacctgatt gatcagcttt acgctgcttg gcatttgccg gaaggggatg aaaaagcatc 461281 tgttttagcg gactggatca agcaggaatt tcagaaaaac ggaaagctgt acgggcggta 461341 ttcggcatat acgaaggagc ctgccgtcca atatgagtct ccatccgtat atgccttagc 461401 cgtattgttt ttgacaaaac agcatgaaaa cagttctgtc atcaaagcca tatatgatag 461461 aatgaatgac tttgaaattc atgatccggt gaaatcgtat tatggaggct atatgagcgg 461521 cactcagacg cattcatttg acaatctgct gccgctgtta gccgaaagga agctttttaa 461581 tgaaaatatc attcagtgaa tcacaaaaat tatttgctta tttttcaggg ctcatcgcgg 461641 ccctgtcttt gtttatttat tatgtgtcag cccagcaatc agaaggtgct ctgatccttt 461701 gcatcacatt tggcgtcatc gccgcaggca tctggttcgg cccgatttac gcgctggcag 461761 tgaccttaat cgtactcttt gttctcggca ccttaatgat gtttttccag actggacaga 461821 catcgctctt tccggctgag gaagggctgc gaatgcttgt cgtgtgggga atcgcgcttt 461881 tgctgttttc ttttatttct ggaagaatcc acgatattac agcagagctt cggcgctcaa 461941 tgacacggct tcaatccgaa attaaaagct atgttgctgt tgacagagtg actggttttg 462001 ataacaagca aaggatgaag ctggaacttt cagaagaaat caagcgggcg gagcgctacg 462061 gcaattcttt tgtgtttttg ctgctccata tgcattattt caaagagttt aagtctttgt 462121 acggtgaaaa agaaacggac cgcctcttcc aatatgtcgg tcagcaaatc aggacaagcg 462181 ttcgggaaac ggataagaaa ttccgtccct ctgacgagcg tatcgggatc gtgctgacgc 462241 acacgcctgc tgaacatatg ccggccgttc tgactaagct gaagaaacaa ttggatacat 462301 atcagctgga aaatggaaag tatgtgtcgc ttacgttcca cgtttgctat ttgccctacc 462361 gcaacgatat ccaaacagct gatcaatttt tagaagaact ggaaaacgag atgatgatga 462421 atgaactata aaggaatcac attgctatgc gtcatgatgc ttctattttc agctattgcg 462481 tcttttcccg tttctgcgca agcgaaagat caggatgccg gcattctcat catctactca 462541 accttggacg gcaaagagtc gtcacaagtc aaaatgctcg atttgcttgc gggccacttt 462601 acatcccatg tgacagtcaa aaaagattca gacgttgaag cgtcggattt caaagggaaa 462661 gaccatgtga tttattacgg ccaaacgaaa agaaagctca gccaaaaatt gctgtctctt 462721 atcagcggcg tgaaaaaacc ggttgtcgcc attggctata acgcaggcca aatcagccaa 462781 ttttctgggc tttcattagc ccgcaaagaa aatgtgtttc aggttcacag caggtcagaa 462841 aaggccgatg tgtctctgga aagcgggctt aacgtgctga gtgtatcagg cctgaaagga 462901 acggcgcttt acaccttcaa agcggatgaa ggcacaacgc attcttttat atggaaaaca 462961 aaaaaaggga atgtgtacat tggattaaca aatttgttaa atgacaattt gatcgtggcg 463021 aaacagctca gagaagcttt cggagagaag gcggggacga cgttattgta tttgcgtctc 463081 gaggatatca gcccgatgtc tgatgaaaaa ctgctgcttc aagccggtac atacctgcat 463141 aagcggcata ttccttttat cctggcggtc attccggttt acttgaatcc ggaaacaggc 463201 gacaaagtgt atttgtctaa tcaaccgaag atggtcaagg tgctgaagaa gctgcaaagc 463261 atgggcggca gtatcatagt tcacggctat actcacgctt atcgctacag tgaaacagga 463321 gagggatttg aattttggga tgcaaaggcg gatcagccga ttacatccgg aaatgccgaa 463381 gaccccccgt ccattttgga gaaagaacag gacttcccga acgaacaagc ctatcacagc 463441 tatcttgaac catttcggga aaaggaagaa acgtatacaa aacaaaaact gacgcgtgcc 463501 attgaggatt tgacatcatc gggtctttac ccgctggcgt ttgaagcgcc gcattacacg 463561 atgtccgaat atggctatca aatcgcctcg cagtatttta caagcatttt cggccaggtc 463621 cagctcagca gcacaacatg gaaaacatcc ggtgcacctc cgtttgtgac tgctccttcg 463681 atgctgcacg gaatgacgct ttatccggaa acgatcggct ttgtcgacac atcgaagcaa 463741 aacccgctcg gtgagatgga ggagcatatc tcccagatga ttgattttga aggcggagta 463801 gccggaggat tttatcaccc gtaccttggg atgaaatatc tgcctgagct ggttgatcag 463861 atggaacgca ttccagacag tgaatggctt gatttaaaga aaacgaaaca aaccgtcaaa 463921 acagacaaag tggaaattca tacaagcggt gacggaacga ttcaggtgaa aaacggcgta 463981 agccccattt acgagttttt cgatcatcac cggcaaaccc ctctggaaaa ggcgttatgg 464041 attctctccg ctgttgtgct cttatttgtc atcatgtttg tcagttatac gttttacttg 464101 agagccacat tgaaaaaacg aatttttaag gagagaagaa gccttgggta atacgctgtt 464161 ctttatctcg ctaagtttaa tatgggttat gcttctctac cacatgttcc tcatgcaggg 464221 cgggtttcgc cactatatga ccttcgaacg gaatatcccg aagtggagag aaaatatgaa 464281 ggaactgccg aaggtcagcg tcctcatccc ggcgcataac gaagaggttg tgattcggca 464341 gacgctgaag gccatggtca acctttatta tccgaaggac cggctggaga ttatcgtcgt 464401 taatgataat tcatcagacc ggacgggtga tatcgtcaat gaattttccg agaaatacga 464461 tttcatcaaa atggtgatta cgaagccgcc aaatgcagga aaaggaaaat cctctgcact 464521 taactcgggt tttgccgaat cgaacggcga tgtgatctgt gtgtatgacg ccgacaacac 464581 gcctgagaaa atggccgtgt attacctcgt gctcggcctg atgaatgacg aaaaggcagg 464641 cgccgtggta gggaaattcc gcgtcatcaa tgcggcaaag acgctgctga cgaggtttat 464701 taatatcgaa acgatctgtt ttcagtggat ggcccaggga ggcagatgga agtggttcaa 464761 aatcgccacg atcccaggca ccaacttcgc gatccgcaga agcattatcg aaaagctcgg 464821 aggctgggat gacaaagcgc tcgctgagga tactgagctg accatccggg tatataatct 464881 cggctatcac atccgctttt tccctgccgc catcacgtgg gagcaggaac cggaaacatg 464941 gaaggtatgg tggcgccagc gcacccgatg ggcgcgcggc aatcaatatg tcgtgctcaa 465001 atttttggcg cagtttttta agctgaaacg aaaacggatt atctttgatt tgttttattt 465061 tttctttacg tacttcctgt ttttctttgg cgtgatcatg tcaaatgcga tttttgtagt 465121 gaatttgttt tatgatttgc atttgtctgt tggatttttg gcaatgattc tctggatttt 465181 ggcgtttttc ttatttatga cagaggtcat gattacgttg agcattgaaa aaacagaaat 465241 gaacaagcaa aactttttta tcgtatttct catgtacttc acatactcgc aggcatggat 465301 tgtgcttgtt atctactctt tattcgtaga aatcaagcac cgtttattca agcaagaggt 465361 caaatggtac aagacagaac gatacaatca acataaaagc gggtgacctt tttgaaacaa 465421 ataatgattt ttctcacaag cttcatgctg ctggcgatga ctggacaaac ggctcttgcc 465481 aaagacgtac aggtcagcgg ttcgctcctt gggaaaagca gccaagaaca agccaaacag 465541 caggtgctga caagcgagct gattacactg tatggatcaa aagacagcgc agagctgacg 465601 tatcagatcc cggcaggcgc ctcttcgggc aatcagcaat tggtaatcga atacgaggca 465661 tcaaatcttt taatttctcc atcatcgtta acggttgtca ttgatgatga accggtcaag 465721 acgttaaagc ttgatggtga ttccaaacgg aaaacagtga agctgaatct gaataaaagc 465781 cagtctgcgc aaggctatca caacgtatcg ctgaaattct acggcgtaat gaaagagggc 465841 gtgtgcgtca gacaggatac atcaggcaac tggatcaaaa tttatccgga cagccggctg 465901 acacttgctg acagcagtga agcgaaggga acgtcgctgg accattatcc gtatcctttc 465961 gcccaatctg gaaatacagc ggaagaaaca gctatcgtca ttccggataa cccaagttca 466021 gcagaaatag aagctgctgt taaaacagaa ggctatttga aaacggtgga cagcagtgtc 466081 agtattgcgt atgtcacgga atctgaactg aaaaaaatcg ataagccgac gattgttatc 466141 ggcgtggaca agcattggaa cggcaaagtg aaaaaactgt tgaaacaagc cgggctacag 466201 gcaaaaggag aaaaccttct gcttgcggag cgggtgctga aagcagaggg caaacagcag 466261 ccggttctgt ttgcgcaagc ggcgtccgag gacgcgctca caaaaaaaat cagcgtgatg 466321 acagatcaga catatacagg ccagctcagc ggcgatacac tttcaatcag caagcttcag 466381 cagactgaaa aaaaagaaag cgataagctg acccttgaga attttggagc gggtgatatc 466441 acaattggag ccgacaaaac atcttcagca cattattttt atccggcttc ggctgtttta 466501 gatgaaaacc aatcggcgaa gctgtcgctt aaactgaaaa agtctgaaac gattcaagcc 466561 tcaacggctg aaaacgagtc agcctctcag gctgcagaac tgaaagtgat gatcaacggc 466621 cagccgcact cggtccggct tgatgaatta ggaaaagaag ataaaaacgg attctatcat 466681 gtcacagtga aagtggaccc taagctgctg caaaaaaacc gctacattga tattcagttc 466741 gtcacgaccg gtttaaagga aaacaaccct tgtaacacca ctgatgaaga aaagtgggtt 466801 tttatcgata aaaacagtac attatcatac gccatcaaag gcatgtcccc gtcagcggat 466861 tttcaagagt ggccgctgcc ttacgccgga aaccaggatc aaacaacgtt aatcgtgctt 466921 cctgacaccg taagccaatc gaagctagag gagctttctc tcgtaacaga atcctttggc 466981 aacgaagcac agcattcata tacggtaaag aaatcatctg acgttacagc aaatgatgcg 467041 aaaggacgaa acctcatttt cataggaggg atcaatcaat tttctcttct gaaggagaaa 467101 tcatcagatc tgcttgtgcc gcaggaaaag aacggctcgt ttgatgtatc tagtttcgag 467161 atgctgaatg agacgacaaa acaagtggta tttacccaag catcggtttg ggattcacgc 467221 tatacaatgg ctgtctttgc accgtcaaaa ggagatggca cggctgtcac aaaagagatc 467281 atcagttatc tgaacagcaa cgatgagtcg gcaaccgtcc ttaatgaaac aaacagccag 467341 caggtgttta caaaccacca gcagctcaaa tcggaaacaa acagttccga tgcagaacaa 467401 ccaacacagg atcatagcca gaaatggatg tatattggtg tgctggcact cattatggtg 467461 gttgcggcag tgttcatttg gattgccgta agacgcaaaa aaagaaagac agatacagaa 467521 taaaacagag gcgattttag cctctgtttt tttatttttg gtaagtaaat tccatttgtg 467581 gaacctgtca ttttattttt ttctctcagc caataagcct ctttacaacg tgcgggaacg 467641 ggagtatgat ctcttttaga aaacaaatcg cttaatctga aatcagagcg ggggacccaa 467701 tagaacggct ttttgccgtt ggggtgaatc ctttttaggt agggctaact ctcatatgcc 467761 cgaatccgtc agctaacctc gtaagcgttc gtgagaggag atgaatgaaa cctgtgttcg 467821 atgttatggc acaggggcat ccgtttgcct ctgtgttttt tgttgttcat ttttgaatgc 467881 aaatcgcata cagagacatc atagcagaaa ggactatcat caacatgtga gagcaagaca 467941 ctgatggatg ttttattgtt ttaattgaaa aatgagaaat taaaagggga agacatcgat 468001 gtatcattca atcaaacgtt ttttgattgg gaaaccacta aaatcccaag cagctggaga 468061 gcaaaaactg acgaaattaa aagccttggc tatgctttcc tcagatgcgc tgtcatctgt 468121 cgcatatggg acagaacaaa ttctaatcat tttggcaaca atcagtgcag ccgcattttg 468181 gtactccatt ccgattgcgg ttggcgttct catcttgctg ctcgcactga ttctttcata 468241 caggcaaatt atttacgctt atccgcaggg cggcggggcg tatatcgttt ctaaagaaaa 468301 tctcggtgaa aaaccgggat tgattgcggg cggttcattg cttgttgatt atattttaac 468361 agtagcggta agtatttccg caggcacgga tgccatcacg tcagcctttc ctgcattgca 468421 tgattatcat gtgccgatcg ctatttttct cgtgttagtg attatgattt tgaacctgcg 468481 cgggctttcg gaatcagcat ccatacttgc ctacccggtt tatctgtttg tggtggcgct 468541 tttggttctc attgcagtcg ggttgtttaa acttatgaca ggacaaatag accagccagc 468601 ccatcataca tcgctcggca cacctgtagc cggcattacg ctatttttgc tgcttaaggc 468661 tttttcctcc ggatgctcag cgttgaccgg ggttgaggcc atttctaatg cgattcctgc 468721 attcaaaaac ccgcctgcgc gaaacgcggc aagaacgctt gcgatgatgg ggattttgct 468781 ggcgattctg ttttccggca tcacggttct cgcgtacggg tatggtacgg cgccgaaacc 468841 tgatgaaaca gtggtttcac aaattgcgtc cgaaaccttt gggcggaatg tgttctacta 468901 tgtcatccaa ggtgtcacat cgcttatttt ggttcttgcg gcaaatacgg gattctcagc 468961 cttcccgcag cttgccttca acctggcgag agaccagtat atgccgcgaa tgtttacagt 469021 caggggcgac cgcttaggct tctcaaatgg gattatcttt ttaggctttg cctccattgt 469081 tctcattatc ttattcgggg gacagacgga gcacttaatc ccgttatatg ctgtgggcgt 469141 atttattcca tttacgcttt cacaaaccgg catgtgcatg aaatggatca agcaaaaacc 469201 aaaaggctgg atcggaaaaa tgctgatcaa ctcctgcggc gctctgatat catttatggt 469261 tctatccatt ctgtttgtga cgaagtttaa tgtcgtatgg cctgtgttaa tctttatgcc 469321 tatcgtcgtt ttgctgtttt ttgcgattaa aaatcactat actgcggttg gtgaacagct 469381 tcgcatcgta gacaaagagc cggaagaaat caaaggcacc gttgtgattg tgcctgtggc 469441 cggtgtcacc accgtcgtgc aaaaatcgat tcactatgcg aaatcactgt ccgatcaggt 469501 gatcgccgtt cacgtgtcat ttgacagaga acaggaaaag aaattcgaaa aacgttggga 469561 agagcttaat aacggagtgc gtctcgtgac gcttcactcc tcttacagaa gccttgtcca 469621 tccgtttgat aagtttttgg aaacagttga ggcaaaagcg aagaaggagc agttttccgt 469681 tatggtgctg tttccgcaat ttataacgaa aaaacgctgg cacaccatcc ttcacaacca 469741 atcggccttc ctcctcagag tccggctgtt ctggaaaaag gacataatgg ttgccacact 469801 gccgtatcat tttaaaaagt aaagctctag gaccaaggga atcaccttgg tcctttttag 469861 cgggaaaagg aggtatgggg gtgtatacac aaggtgcttt tgtgatcgta ttgaacgaaa 469921 gtcagcaaat tctgctggtg aaacgaaaag atgtccctct atgggatttg ccgggcggca 469981 gggttgatcc cggggaatcg gctgaggaag cggcagtgcg ggagatattg gaagaaacgg 470041 gatacaatgc agcgctttct gcgaaaatag gtgtttacca aaggccaaag tttcaagatg 470101 aacagcatct gtttttcgga agcattacag gcggacaagc aatggctgac ggcacagaga 470161 cagcgggatt aaagtgggtt tccccggggc gtttgccgct ttttatggtg ccgaatcgaa 470221 aaaggcagat caatgatttc aagaacggcg ctcaagatgt aaatgtcacc gtcaaggata 470281 gcgggttgct cgcggcgatc gacctgttga aaagaagact gggcaagtga ttcaggtctc 470341 cgggttttaa agcctttctc ctgtggtatt gaaaaaagga aaaaggagga tacgttatgg 470401 cacacaaaac tgcaggacaa gcaatgacag agctgcttga gcaatgggga gttgatcatg 470461 tatacggcat ccccggagac agtataaatg agtttatcga agaattaaga cacgaaagaa 470521 atcaactgaa gttcattcaa acccgccacg aagaggtagc ggcactggca gccgcggctg 470581 aagcaaaact caccggcaag atcggagtct gtctgtcaat cgcagggccg ggagcggtgc 470641 acttattaaa tggtttatat gatgctaaag ccgacggcgc ccctgtgctg gcgattgcag 470701 gacaggtttc ttctggcgaa gtcggacggg actatttcca ggagattaag ctggagcaaa 470761 tgtttgagga cgtggccgtg ttcaacagag aggtacatag cgcggaatca cttccggatc 470821 tcttaaatca ggcgatcagg accgcctaca gcaaaaaagg cgttgcggta ttgagcgtgt 470881 cagatgattt gtttgcggag aaaatcaaac gggagcccgt gtatacttca ccggtgtata 470941 ttgaagggaa cctagaaccg aaaaaagaac agctcgtcac ctgcgcccaa tatattaata 471001 acgctaagaa accgattatc ctggcagggc agggaatgaa aaaggcgaaa cgggagctct 471061 tagaatttgc ggacaaagcc gccgctccga tcgttgttac actcccggca aagggtgttg 471121 ttcccgataa gcacccacat tttctcggca acctcggtca gatcggaaca aagccggctt 471181 acgaggcaat ggaggaatgt gatttattaa tcatgctcgg aacgtcattc ccgtaccgtg 471241 attatttgcc tgatgacacg ccggcgatac agctcgattc agacccggca aaaatcggaa 471301 aacggtatcc ggtgacagcg ggccttgtct gtgattcggc tctcggtttg cgcgaattga 471361 cagagtatat tgaacgcaag gaagacagaa gattcctgaa tgcctgcaca gaacatatgc 471421 agcattggtg gaacgaaatt gaaaaagatg agacagaggc aacaacaccg cttaaacctc 471481 agcaggtcgt ggcccgtctt caggaagcgg cagccgatga tgcggtgctc tctgtagatg 471541 tcggcactgt gacagtctgg atggcgcgtc atttcaaaat gaacgcgaat caggatttca 471601 tcgtttccag ctggcttgcg acaatgggct gcggcctgcc gggagcgatt gcagcgagct 471661 tgtccgaacc ggaacgccag gcgatcgccg tctgcggtga cgggggattt tccatggtca 471721 tgcaggacct tccgaccgcc gttaaatata agctcccgat cacagtcgtt attttaaaca 471781 acgaaaatct cggcatgatt gagtacgagc agcaggtcaa aggcaatatc gactatgtca 471841 caaaacttca aaatgtcgac tatgccgcat ttgcagaaag ctgcggagca aagggcatca 471901 aagtgaccaa agcggaagag cttgcgccgg cttttcatga ggcgctgcac tctgaccaac 471961 cggtcgtagt ggatgtcatg attggaaacg aaccgccgct tcctggcaaa atcacctacg 472021 ggcaggcgaa aggctttagc aagtacatgc tgaaaaactt cttcgaaaac caaaaatttg 472081 aaatgccgtc actgaagaaa agtttgaaac ggttatttta aaaaaacagg ggccctaaga 472141 gcccttgttt tttttttttt ttttggaaac aaatgtattt tcagcatgtt tgaattcata 472201 aaatgatcgg tatatgtatt aggaactgat ttcgccatac tcgaaacaga caaaaggaca 472261 aatgcatctt gtttcaaagg aagatgcatt tgtccttgca tgcttattct tatcaaatct 472321 tacagaactc ttctcataat aggttatttt tcttttttct tcagcccgaa gaagaaagga 472381 aaagcagaac cgaccaagaa ggtgccgaat aaaaacatgc cgccgataaa cacgtggaaa 472441 tttgtgtgtc cggccgtaaa cgccgtgatt agggaaatga tactgagcac gatcatggca 472501 atgccgggcg cgactctcat ttttcccttg gatttatggg cagcaacaga acataaaatg 472561 ccgataacaa taggaacaat ccacaaataa aacagaataa atactgacat catcaaaact 472621 ccgatttttc ttctatcata acaaatttct gtcaaaaagg gtatcaatga gcttttgcgg 472681 aaaaataaaa accggcttta gaagccggtt tttttatcga aacgtatcta caattaaaaa 472741 cacattcaaa gcaacgatca atacagcaat cagccaagac accactgtga tccatttggc 472801 gttgatcaga gatcccatga tccgtttatt gcttgtaaac ataataagcg gaatgagggc 472861 aaaggcgatc ccgaaggaca gcacgacctg gctcagtacg agagcggtcg tcggattaac 472921 acctgacgcg atgatcaaga tcggcggaat gatcgtgata aaacgccgta catacagcgg 472981 aatgcggtag ttgataaatc cttgcataat cacgtcgcct gaaagtgtgc cgacagacga 473041 actggataga ccggcaacga gcagcccgat cccgaacaaa gccgcagaca tagggctgac 473101 aagatgtccg aattgctgaa atgcgacgtc gagatcctca acaaacaggc cgtttttgaa 473161 gaataatgcg gcagccacaa tcagcatact tgcattaata gcccctgcaa tcagcatcgc 473221 tattaaaata tcaataaatt caaacctaaa gatttttttc cgttctgcat cagttttgcc 473281 aaccacccgc cgctgtgtaa gggcagagtg taaataaatg gcgtgcggca taacagttgc 473341 gccaagaata cccgctgcaa gaagcacact gtcggtgcca tgaaacgccg ggacaaaaag 473401 gcccttcatc actgacacgg catcaggctt tgcgaaaaag gtctgcaacg caaaggcgat 473461 cacgaccaca aacagcatac cggcaatacc tgcttcaagt gagcgataac cacggcgctg 473521 aagctccaat atcgcgaaag aaccgatcgc cgcaataata gacgcttcaa gcatcggaat 473581 gccgaacagc aaatacagtc ccagagccgc tccgataaat tccgccagat cagttgcgat 473641 aatgaccaac tcgccctgaa tccataatcc gatcgagaca ggcttcggga attcttcacg 473701 ggcaacctca ggcagatttt tgcctgtcgc aataccgagt ttggcggata gggattgaat 473761 taaaagcgcc atgatattgg aaaataagat cacccataag agcatatatc cgtatttaga 473821 acccgccgaa atattcgttg cgaagttgcc gggatcaata taggcaatgg ctgctataaa 473881 tgcagggccg agaaaaggga gcagccctct gaatcctctg attttcccgt caagcgcatc 473941 ttggacggct ttggaacggg gagattgtgc tgtgatgtcc ttgttcatca tgtctcacct 474001 gaattctgtt tgtttttgcc gtacaacaaa gagtttcctt aaggcaaatt attttatcta 474061 catcatatga ccatcccggt ttcttgtcaa ccgaaaatgt tcaaaataca cttctgaatt 474121 tttccctgtt atgtaacatg atatgtaggg attcgtgata aggtcccata taaaaagaca 474181 tcgtttcatt tcgaaacgat gcctcctgta tctaatgagt ctaggcttcc ttccgcagcc 474241 cgcggaatat aaggcccagc aagaacacga agatggctgc cccgatgatg gccgggaaaa 474301 tagcaaagcc ggcgaggctc ggtccccatg tgccaagaag tccgtgccca atccaagcgc 474361 cgatcagccc ggcaatcata gagccgaaaa ttcctcccgg cagccggttt cctacaatgg 474421 cgctcccaat taatccgata acaattgcaa caactaatga aaccaaaaag ctaagcatca 474481 tgatcacctc tcataaatga tttaccaatc aataaccgct cctgatcatt tcgaaacact 474541 tgaaagcata ttcctttatg atcctgtttt aatctttctc tgcacactgc cgtcagctaa 474601 atgaacaatg acctcagtgc ctttatgcgc cgcgatttcc tttgcccgtt caatcgcttc 474661 tttctttgta tccttgattt cagacacacg tttggcgccc tcggctttga ctgcccagcc 474721 ttttttatgc ttaataacat gctctgcttt attcatgagc tcggggccgc tgccgctgct 474781 tggatcagca tcgcgttctg tctcatcatc atgcgtcagg aaatcatcaa tttcatctgt 474841 agaggcgttt tccgcccatt ccttcgcttt gcttgtcgca attggaatcg cgcgcccttc 474901 ctcatagcct tcatcaatca tcgcattcgc aatgtctatc gccttttttc tcaccggctt 474961 ctcaagattt tttaatgaag caggataatc cttcatcgac caaggcatgt ctatcactcc 475021 ttttcctttt ataaaaatgg tacccgcagg tgaaaaataa aaacgcatcc gaaaaaatga 475081 aggtatacta tatagtagaa aaaacggaag ggaagtgcgg gttgggtgcc aacagaacga 475141 aaagaagact tacatcagca attaaaagag atagagaaat gggaaaaaga tcagcaaaaa 475201 gtctggtttt gggaaaagct cagccgtctc ccgtttcaac tcctggacaa gctgacacca 475261 gaattcatcc agaaaaagat cggcaagctc ttggatgagg tcggcagctt tgttcaaaca 475321 ggcggacagt acctgacatc tgaaaaacag attatcagga tgtttcaaaa gaaactgccg 475381 gaggagatct ttgaatcgct ggaggacatc cggaaagcgc ctcttcctgt catggatgaa 475441 attgcggaag gaatgggcaa aaacagaacc aacgcagcaa ccgttcaagg cgcgacaacc 475501 ggtgtgggcg gcgtgtttac gctggcggca gacattccgg cagtgcttgg cttatcacta 475561 aaaacattac aggatatcgc agtcgcatac ggctatgacc caaaggagaa aaaagaacga 475621 gtcttcattg tgaaatgcct gcagcttacg tcggctgatg ttgtcggcaa aagatcgatt 475681 ttgcaggaat taaaacacta cgatcaagac cgtacatata agaatgtcgc ttctcaaatc 475741 caaggctggc gagaagtcgt tttgggctat cgagacacgt ttggctggaa aaaacttttc 475801 cagatagtgc cggttgccgg aatggttttt ggcgccgctg ccaatcgctc aacattaaac 475861 gacattaccg agacaggcat gatgctgtac aaaaagaggc gcattcttga acgactgaaa 475921 gaaacagaac gagagatgga atagcagaaa gcagacggac accgcgatcc gcctgctttt 475981 tttagtggaa acatacccaa tgtgttttgt ttgtttaaaa gaattgtgag cgggaataca 476041 acaaccaaca ccaattaaag gaggaattca aaatggcaga caataacaaa atgagcagag 476101 aagaagcagg tagaaaaggc ggagaaacaa caagcaagaa ccatgacaaa gaattctatc 476161 aagagattgg tcaaaaaggc ggagaagcca ctagcaaaaa ccatgacaaa gaattctatc 476221 aggaaatcgg cgaaaaaggc ggagaagcca ctagcaagaa ccatgacaaa gagttctatc 476281 aagaaatcgg tgaaaaaggc ggagaagcca ctagcgaaaa tcatgacaaa gaattctatc 476341 aagaaatcgg ccgaaaaggc ggagaggcaa caagcaaaaa tcatgataaa gaattctacc 476401 aagaaattgg ctcaaaaggc ggaaacgccc gcaacaacga ctaatcaaaa gcataaaggc 476461 agacaacctg taaataaaaa agcgatccgg cacatcagct ggatcgcttt tttttggaat 476521 cttctcaatt tatgccgcta ttgagataca ataagtgaaa aaggggtttt cgctaatgtc 476581 caagatgcaa aacttgctcg ccatcgcaaa tgaagtcaaa gaaaagcacg ccaatttttc 476641 aatctcagag gtcaacgacc actgcgtgcg ccttgcggtg tttacgggag aatatgactg 476701 gcaccatcac cctgactcag acgaattgtt tattgttctt gaaggggagc tgctgatcga 476761 ttttaaggac aaagaaaccg cggtgctcaa agcaaatgac agcctgctga tccctaaagg 476821 cacggttcac cgcacacgct cttacgtcag aacggtaaat ctctgtgtgg agcataaaca 476881 agccgaaacc gtcatcatag aggagcagcc atgctaatca aaaagatgat atgtgaagta 476941 gatgctgcaa acgctgaagc atttgcaaaa gcgcagtcac agtgggaagc gttatcgcat 477001 ataagcggct ttatcaaaca ggccggcggc tggcgaaaaa cgatagacga gccgctcacc 477061 gcagaaatca tcagtgtatg ggaaaacaga gaagcctatg atcattttat ggagaacgaa 477121 catgacagca tatacgagga aaacgatcag aaggctgtaa ttctttcgat agaggtgacg 477181 gtgtacgaag aggataaacc gttcgttcac gatctgttac ataaccccga tatccggtac 477241 gaaccaaact ggacggttct gaaggcataa tcaaagccca aaacatcatg ttttgggctt 477301 gtctctttac tcgcgtcccg gaagtgtatt atgaacaaaa ggcggtgctg gttttaactc 477361 cggtttttct ccaaacgttt ttgcttcttt cacatattca aaggcttctc cgtccggcgc 477421 tttttcattc agccagtttt gctcggcgct tacttcgcct tcagagaaat tgataagctg 477481 atgtgagaac tcttgttttt cgagcgcttt cgggaatgta cccggcacaa ccggaccttc 477541 ctgtgcttct aattctttaa tggcggcgag ccattggttc tggtgcatcg tgtcacgcgc 477601 cagcaggaag ctgagcatat ctttgacgcc tttgtcatcc gtcatttcaa acaggcgtgc 477661 gacctgcaga cggccctgag attccgcatt caggttggcg cggaagtctg ccagcaggtt 477721 tccgcttgct acgatataac cgccgctcca aggtacgcct gtactgcttt ccggcatggc 477781 gccaagtcct gatacaatcg catggtgagg gttcatgccg cctaggatgg agccgatgac 477841 cggatcttca gcagcttttt cctgctgatc aagaggggca tcctcaagaa gtctggcaat 477901 catcgttgcg atcatttcaa catgcccgag ctcctcagtt gccgtatcca tcagcaagtc 477961 cttgtatttt tcatttcctc ttgtgttcca gccttgaaat aagtactgca tggcaactga 478021 aatttctccg aattgcccgc ctaaaatttc ttgcattttt ttagcgaata atggatctgg 478081 acgatctggt ttagcaggat gctgcagcat ttttgtgtgc ttaaacatgt acccatctcc 478141 tttttcgttt atctcttttt atatttccga tcgatagaaa gataaacgaa aaacagcgta 478201 tcgagatggg aactatgaat cttttcgcag ctccaacagt tcccggatca gctcccggcc 478261 aaagatgggc tcatactgcc ggtaaacagg gtcaagacgc ttcatccatt cttgtttctc 478321 tttatctgac agctcataaa tatgtatagc agaattcttt ttgatttctt ccagctgctc 478381 cttgttcatt tgttcggcat acgtttcatt ccactccgtt gtctccttca tcgcttcagt 478441 caaaatgcgt cttgtttctg gtgtttgcgc cttccagaag tgttcatcag tcatgacagc 478501 gtagccgaga taaccgtggc tgcttattgt caaatagtcc tgaacattat aaaatttttt 478561 agaatagatg tttgaaattg tattttcttc gccatcgact acattgtttt ctaacagctg 478621 aaaggtagaa ttgaaggatt cctgatgagg tgttgcgcca agcagcttga actgatcctc 478681 aatcacatcg ctttgcataa tgcgcagatc ctgccctttt aagtcatccg gtgttttgac 478741 cggcccttga tttgttgtga tttgcttaaa gccgttcgtc caataggcca atcctttcaa 478801 ttggtttttc tttagagaat caaacagctg tgtgccgatg cttccgttca gccctttttt 478861 gacggcgttg taatctgtaa atgcatacgg cagatccagc actccccatt caggcgagag 478921 catgccgagc ttcgatgtgg agggggcgat aaattgaaca tcgccgtttt gcaatgcttc 478981 aatttcttca atgtccgagt acaggcttcc attcggaaat acttctattt ttatttttcc 479041 gcctgatttt tcgttcacca gatcagcgaa tttattggcg gccagccctt ttggcgtatt 479101 ttcagcaacc acgtggctga atttaaacac gatttgatcc tgcaggcctt cctggtcgtc 479161 atcataaaca atctttttat tgccggtatg atcatggaat ccgataaata aagcggttgc 479221 aattccagcg atcatcagtg cgagacatgc aagcaaactc ttcatgaaaa gccctcccct 479281 atgttaagga taatgggggc tatgacattc gtaaagacct gaaaggagaa gctgatgaac 479341 aaaaagaagc tctcaatccg ttggaaaatc acgatcttat cctatatact cgtcattttc 479401 tcctttttga tcggcggcat tgtgctcatc ggcaacattc agcatacaga ggagcgggag 479461 ctgaaaaagc ggctgatgaa tacggcccgg acggtgtcag agatgacaga agtgaaagaa 479521 gccttggcgc gaaaaaaaca aacagaagcg gttcgccatg cggttgaaga aatcaggatg 479581 attaatgaag cagactatat tgtcgtcatg gatatgaatc acatccgata tacgcatcct 479641 gtcagcacaa gcattggcaa gaaatcagaa ggtgcagacg aggaggcagc ttttgcggag 479701 cacatttatt tctctgaagc aaagggcgag atcggcacgg cggttcgcgc tttttatccg 479761 gtaaaggatc aagacctgaa ccaaataggc gtggtgcttg tcggaaaaac gctgccgggg 479821 atcgctgaca tcctgcttca tttaaagcgt gatatcgcct tcatcgttgt gctgacactc 479881 ggctttggcc ttgctggttc ctttttgctg gcccgccata tcaaaaaaca aatgtttcag 479941 cttgaacccc atgagattgt ccgaatgtat gaagaacgga cagcgacgtt tcactcgatg 480001 aatgaagggg tgatcgctat tgacaatcgt ctcgtcatta cgatcttcaa tgaaaaagcg 480061 aaacagatct ttgaagtgca gggggatcta atcggcaagg tgatttggga ggttctcaag 480121 gattcgcgcc tgcccgaaat cgtggagcgg aacaaagcgg tttataatga agaaattcgt 480181 gtcagcggta aggtgatcat gagcagcaga attccgatcg tcatgaagaa aaaagtgatc 480241 ggcgccgttg cgatttttca ggacagaacg gaagcggcca agatggcaga ggaattgact 480301 ggtgtcagaa actttgtgga ggcgctccgt gtccaaaacc atgagcatat gaataagctg 480361 cacacgatcg ccggtctcat ccagctgggg aaatctgaaa aagccttgca gcttgcattc 480421 caggcgtcaa ctgagcagga aaatgtgact gaatttctgc accgctcgat tcaaaatgac 480481 gctgcggcag gccttctatt aagtaaaatc agaaggggaa gagagctcgg cattgctgtt 480541 catatagatg aaaacagcag tcttcagcaa tttcccgagc atgttgatca gcatgatatt 480601 gtcgtgcttt tggggaatct gattgaaaat gccttcggct catttgaaac cgttcaatct 480661 gaagacaaac gaattgacat tagtatcgaa caaacagatg atatccttgc tattttaata 480721 gaagataacg gctgcggaat tgaaccgaca catatgcctc gcctttatga caaaggtttt 480781 acggtcaata aaactggcgg cacaggctat ggcctgtatc tagtgaaaca aatcatagac 480841 aaaggatcgg gcacgataga agttgattca catgcggggc aggggacatc tttttctatc 480901 gtttttccaa tgaaggggga ggaagcacag catggctcgt aaagaatgga aggttctgct 480961 cattgaagac gatccgatgg ttcaagaggt caataaggat ttcattacaa ctgttaaagg 481021 cgttactgtc tgtgcaacgg caggaaacgg agaggaaggc atgaagctga ttaaagaaga 481081 acagccagat ctcgtcattc tcgatgtgta catgccgaaa aaagacggca tcaagacctt 481141 gcaggagatc agaaagcaaa agcttgaagt ggatgtcatt gtcgtctccg ctgcaaaaga 481201 caaggaaacg atctcactca tgctgcaaaa cggggcggtt gactatatct taaagccgtt 481261 taagcttgag cgaatgagac aggcactcga aaagtacaag caatataaac aaaaaatcga 481321 agcgaatgat acgctgtccc aggaacagct cgatgcgatc ctgaatattc cgcagcaggc 481381 cgtacaggat ctgccgaaag ggttgaatca cttcacgatg aatgaagtca ctgctttttt 481441 gaaacagcaa accgcatccc tttctgctga agaggttgcc aaggcgctcg gcatcgccag 481501 agtgacagcc agacgatatc ttgattactt agaaaaaacc gggatcatca aattggacgt 481561 tcaatacggc ggagtcggcc ggccggtcaa ccgctacgtg ttaaaaggat aaacctgaga 481621 ccaaaaagac caaaatgtcc gttatgatca taaacttccc cagactgtat gaaaacgcta 481681 tcattctagt aagaaagaca caaaaggcga ataggacagg gggatgaagg atatgaaact 481741 gtttaaaaat ttaacagttc aggtcataac cgcggtcatc atcggggtca ttgtcgggct 481801 ggtctggccg gatgtcggca aagaaatgaa accgcttggt gatacattta tcaacgctgt 481861 taaaatggtg atcgcaccaa tcattttctt cacaatcgtt ctcgggattg caaaaatggg 481921 cgatatgaag aaggttggaa aagtaggggg aaaagcgttt atctatttcg aggttgtcac 481981 caccctcgca ctcattatcg gtttatttgt cgtcaatatt atgaagccgg gtgcgggtct 482041 tgattacagc aagcttgaaa aaggagatgt atcacaatac acgcaaaatg gcggtcaggg 482101 aatcgactgg attgaattta ttacacacat tgttccgtcc aacatggttg atgccttcgc 482161 aaaaggggac attttgcagg tcttattctt ttctattctt ttcggagtgg gtcttgcggc 482221 attaggcgaa aaaggaaaaa gcgtcattga tttcttcgac aaggtttctc acgttttttt 482281 caaaattatc ggctacatta tgcgtgccgc gccaatcggg gcattcgggg cgatggcgta 482341 tacaatcgga cacttcgggc tcgattccat caaaccgctg gcaagcttaa tgatgtctgt 482401 ttatattacg atgttcctgt tcgtatttgt tgctttaaat atcatctgca agctttacgg 482461 attcagcctg tggaattacc ttcgcttcat taaggatgag cttttgatcg tgcttggcac 482521 aagctcttcc gaatcggtgc ttccgcgtat gatggataaa atggagcgct acggctgttc 482581 caaatccgtt gtcgggcttg ttattccgac gggctattcg tttaacctcg acggcacatc 482641 catctattta tcaatggcga ctgtcttttt ggcacaggtg tttggagtag acctcagcat 482701 cggccagcaa attacgatta tcctcgttct gatgctgaca tcgaagggag cggcaggtgt 482761 gacgggaagc ggatttatcg tccttgcctc aacgctgtca gcgctgcagg tcattccgct 482821 ggaggggctt gcactcctgc tcggggtcga ccgtttcatg agtgaaggaa gagccattgt 482881 gaacctgatc ggaaacggaa tcgccacgat cattgttgcc aaaagcgaaa atgaatttga 482941 tgaagcaaaa agcatagagg ctgttgaagg catgaaaaaa atgaaaacag cagtctgaaa 483001 aaagaacggc ccatccatgg gccgtttttt taattgttta agaattatta aggtaaggac 483061 agagacctca gcattttttt gttatataat ttacaaatgg atactatatt gaatgaagga 483121 cgtttgtcct aacaggagtg tataaatggc cgctttagtt aaattttttc agcacccggg 483181 agtaaggcgt ttctccatct ttgtcgtgtt aactggtgtg ttatatctat ttaagagcat 483241 gatcaactta atattgctta ccttcatttt cacatttcta atggatcgtt tggagcttgt 483301 cgtgcggcag tttgtaagcc agttcttccg cgtgagccag cgggttgtca ttacgtttct 483361 ttacatgttg ctggctgtgc tgcttacagt cgggggcttt gtgttttatc cggtcgtcgc 483421 ggcgcagatc cagcagctgg taaagcagat taaacatatt gcgtatcatc ctgacagcat 483481 ccctttcttt gatgagatca ccagtgtctt cggagatatt aacatcagtt catatgtcaa 483541 agagggcttc aatgtagtgt atacgtatct ggccgatatc agcacattcg gcttgcaggt 483601 cgtgatggcg ctcattctta gcatgttttt cttatttgag aaaaaacggc tttctgaatt 483661 catggcgaaa tttaaaacga gcaaacttag ggtcttttat gaggagattg cttttttcgg 483721 aagcaaattt gcaagaacgt tcggcaaggt gctcgaggct caatttatca ttgcgctcgt 483781 caactgtatt ctgacgttta tcgcgctttg gattatgcat tttccgcagc tgtttgggct 483841 ttcgattatg gtgttcttcc ttggattgat ccctgtagca ggcgtcgtca tttccctgat 483901 tccgctcagc attatcgcct acagcactgg cggtggaatg tatgtgctct acattgtcct 483961 tgtcatattc gccattcatg cgatcgaaac ctatttctta aatccgaagc tgatgtcggc 484021 gaaaacagag ctgccaatct ttttcacctt cacagtactc attttctctg aacacttctt 484081 cggcatttgg ggtttaatta tcgggattcc gatctttgtg tttctccttg atattctgga 484141 tgtcaccaac aaggaagata ggtctaaagg accccgagag aatagcgata aaaagtagtt 484201 taaaatcgaa taatgagtgt gcctcgatct gccggcctgc ctgttcaggg catggaatta 484261 agactcggaa tcggagcttg gcattgcctt gcacagtggt gaacacaaca ggtgacaatg 484321 cttgtcatca gtacggaaac tgaaaagaac aaacagtcgg agcaaacgct catcatcggt 484381 ttaaccaaac atttggaagc aacaaatgct ataatacaaa cagtgcctaa tgttgggcac 484441 tgtttatttt ttgtcgaaaa aggaggaagg ctttatggct gagccgattt tacatattga 484501 aggcctcgat aaaaaaattg ggtctaaaca gattttaaaa cagatcagca tggacgtcat 484561 ggagggtgaa atcatcggcc ttctcggtcc gaatggttcc ggaaaaacaa cactcatccg 484621 tatcatcgtc gggctgttga aacaaaacag cggaagcgtg acaatcagcg gattccagca 484681 tgatacagag tttgaaaaag cgatggaagc ggttggagcg attgttgaga accctgagtt 484741 ctatccgtac ctgacaggct gggaaaacct caagcacttt gcgaatatgc acaaaaaaat 484801 agcggatgaa cggcttgatg aagtggtgga acgtgtcggg ctgacgtcag cgattcatga 484861 taaggtgaaa acctattccc ttgggatgcg ccagcgtctg ggaatcgccc aggcaattct 484921 tcaccggccg aagcttctca ttctagatga accgacaaac ggcctcgatc ctgcggggat 484981 gaaggatttt cgggatcata ttaaggaact cgcagaaatg gaaggaacag ctgtcctgtt 485041 cgccactcat ttattgcgcg aggttgaaga cttgtgcgac cgtgtcatca tcattcaaaa 485101 aggtgagatc aaagcggaag tcagcttaca aggaaccgat caaaccacag aaaaagcgat 485161 tatagaagtg cagccgcaag aaaaagcgct caattggctg acaggcaatc aatatcaagc 485221 tgagagccaa gacgggacga ttgtagttga ggtggcaaaa gaaaacatac cggagctgaa 485281 ccgatcactt gtcggacaag atctgaatgt attttccatt acgccttaca cgcagtcact 485341 ggaagacgaa tttataaaag cgacaacagc tcatcaagag gagggagaag agcttgtcta 485401 aattaatttg gaatgaacat atgaaacttt ttaatcggaa ggtcactttg gtttctctta 485461 tcctgatggc tgtctttcaa ttcttcatgg cattgatcat taaacggatt gtcatcagtg 485521 ccggaacaga tgaaaacttc atcggctatt tatcgtatac accgagcctg aacattttgc 485581 tgcaggcttt aacgatcgta attgcagcaa caattgtttc gatggaattt gataaaaaga 485641 cgatcaaatt tttgctcatt cgtccggtta aacgccaaaa ggtcttttgg tcaaaattaa 485701 tcacagtcgt gatggtcagc ttctatttgt atttggcata ctacattctg gcattattat 485761 tcggtctctt gttttttggc acatcggtga ctgcggaatc aaagacattg ctggtcaaca 485821 ccttggcgct gatcgggtca aactggcttg aagctgtaat gatgggatta ttcgggctgc 485881 tttgttcttc gctgttccgc aatagcgcgg tagcagttgt tgtttctttt gtcgttttat 485941 acggagcgag tacacttgtt cagctcatga agttgtttga aaacaagtgg ggcagctttt 486001 tgctttttgc gaacactgac tttacgcaat acagaagcgg agagacagcg ttgttttcag 486061 gcatgacgcc attgttttca attggaattc tcatcataca tgccatattc ttcatcgttg 486121 ttggctggtg gtgcttctgt aaacgggatg ttcgggtcta aaggcaagga atgacatttt 486181 tgtgaaaaag ctcacgtaaa tcaatatcat ttgatatttt ggtttatact aaaggtactg 486241 acggaggtgt ctcgattgag gaactttatt accgctttac cgatcgtatt gctgcttgga 486301 ttctcatttg tgtcattcat gtttcagttt gaacatcttg tttatttcag gctcgcgctt 486361 gggttgtttt ctctcgtggg actgtacatg atatataaaa tgaagacggg catccgctat 486421 tttatcatct atctgtatgc cagctggatt gtgttggccg cagtgaccgc ttttgaagag 486481 ccgattttct caagcttttt ctttggcggc ctggtgatga cgatgggtta cctgacatat 486541 atgctgattt atctcggcat gaaacaagac cgggatgcaa atcctgtgta atcgcgctgt 486601 tcccttgggg aacggcgtgt ttttctatac tgggcaaaag gttaacagtt gcggaaaaat 486661 ggcaggaaat ctataataca tattaaattt atcggaatta aaactggggg gctgccggat 486721 gtcattattt atacaaaacg atcaacagcg gcaatggatg gagaaaatcg gacggattgc 486781 ggatgaattt cagcaaacag ctgctgaaga tgacgaacag ggacgttttc ctgcagagaa 486841 aatacaaaaa ctgcgtgatg ctgggtatac agcattaaca ttgccggcat ctcatggcgg 486901 agggggcatt tctgtttacg atatgctctt gtttcaagaa cggcttgcac ggggagatgc 486961 tccgacggct cttagcatcg gctggcattt gagcgtgatc ggggagcttg gagaaggcaa 487021 cagctgggat gaagacgtat ttgcatttgt tgccaaggaa gtccaaaacg gagccgtcat 487081 taacagggcg gcgactgaag cgaaaaccgg aagcccgaca agaggagggc gtcccggtac 487141 acacgccgtc aaaaaggatg gcaaatgggc agtgaacggg agaaaaacct ttacgacgat 487201 gtcacaagct ctggattatt ttttagtaac cgcatggatt gaggacaaac aaacaacagg 487261 cgtgtttctc attcataaag atgatcccgg cttgtcgatt gaagaaacgt gggatatgat 487321 ggcgatgcgg gcgactggga gccatgacct tgtactgaac gaagtaatgc ttgatgagaa 487381 taagctggtg gaactgcttc aagggcctcg tggagctaag ccgaatggct ggctgcttca 487441 cattcctgcg atttatcttg gtgtggctca agctgctcgt gactatgcag tgcaatttgc 487501 atctgagtat tctccaaaca gcttgaatgg accgatcaag aatgtcccgg ccgtacagca 487561 aagaacaggc gaaatggagc ttgaactgct caatgccaga cactttcttt tccatatcgc 487621 tcaattgtat gacgatccgg tgcggcgtcc acacttgacc agcgagctcg gtgcggcgaa 487681 acatatcgtc acaaacgctg cgctgtctgt tgttgataaa gcgatgagaa ttgtcggggc 487741 caaaagcctg gaacgaacca acccgcttca gcgctattac cgtgatgtgc gcgccggtct 487801 tcacaacccg ccgatggatg acgccgtgat acacaagctg gcagctgaag cgtttgagtc 487861 ataaaaaaaa gagccttacc ggctcttttt atgtattgtt ttgctcttgc agattttttt 487921 gatgcttgcg gtcgatcctg tcataaataa cgttcatcag ctttggattg cccataatcg 487981 cctctttgtt ttcctggatc agctgttggt aagttttcac tttacgcttc ggcatgctcc 488041 ggcgccctcc tgacatgttt gtattcactt tctaactccg tcagcgacaa ttcatacaga 488101 tgacgctttg actttttgta tataccattc tgtattaaca gatgaatgag ctgttttttt 488161 ctgatttctg cagactgagg tgtcattgtg tcaccaacct ccaatcaaac gatattgata 488221 atcattatca attaacttca gtatacaatg tccgcaatag cctgtaaaga tgaaaagagt 488281 cctattcttg gccaatttac aaacattcaa caaatcgaca aaaagtttcc cgggcaataa 488341 tttgctgtcg aaatattccg cttcattgaa cgcaccctgc tatttttcat gttttgaacc 488401 atactatgta atagaatgga ggctggtatt caatggagcg gacagaaaat ctgaaaaagg 488461 gagaaaaagg ggcgctcctc aatatttttg catatgtcat ccttgctgtt gtaaagctag 488521 ttatcgggat tctatatcat tctgaagcgc tgagagcaga cgggttaaat aatggaacag 488581 atattgttgc gtcagtagca gtgctgatag gattgcggat ttctcaaaga ccggctgaca 488641 gcgatcatcc atacggccat tatcgggctg aaacaatttc gtctcttgtt gcgtctttta 488701 ttatgatggc agtcggcatt gaagtgttaa tcggcggagg aaaagcgatt gcgggcggca 488761 caacggaaac gccaaatctt atcgcggcat ggacggcgtt aggcagtgct gtgtttatgt 488821 atggcatcta tttatataac aaaaggctgg cagcgtccat taaaagctct gccctgatgg 488881 cagcggcaaa ggacagcagg tcagacgctt ttgtaagtgc cggcgcgttt atcggtgttt 488941 tttcgtccca gctgaagctg ccgtgggttg atccggtaac ggcttttatc atcggcatca 489001 tcatttgcaa aactgcgtgg gatatcttta aagacgcttc acattcctta acagacggct 489061 tccatttaaa agatcttgag ccttacaaac agaccgtcgg caggatcgaa aatgtgcatc 489121 gcctaaagga tgtgaaagcg aggtatttag gcagtacagt tcatatcgag atggtgatta 489181 cggttgatcc gaagcttaca gtagaagaag gccatggagt ggcggatgaa gtagaagaca 489241 aaataaaaca tgaacacgat gtcactcatg ttcatgttca tgtagagcct gacgacataa 489301 aataaggctg tttaacgaat tagcttatat gttcagataa aaattcagtc acttcttcag 489361 gcgttttggc attggcgctg tgaaggtgag ctgttttttc accgttcttg aaaataagca 489421 ggctgggaat gcccattact tggtattttt cagccaggtc aggaagctcg tccttattca 489481 gctcatacca gtcgttttgg ttgtattctt ccaaaatatc gccgatgaac atattcatgc 489541 gtgtgcagtc tgggcaccaa tcagcataaa actttacaat gatttcttta tcagattgaa 489601 tcagttcatt aaattgttcg tttgttgtga tttttttcat atgtcacatc tccttttcaa 489661 tgccatttta atataaaata aaaaggaatt acatacaaat gcattcaaca tcagcatgcc 489721 caaaaataat tagatcattt tccggtgaaa atgataagat agtaaagatg aattgtagtg 489781 gggggagtat ccattgaaaa caagtctagg attagtgtac ggaggaaagt cggcagaaca 489841 taatgtttcc ctgcagacag ctctggctgt aatcaaagcg ctaaatactg agaagtttga 489901 tatacatccg atttatataa cagaaaaagg cgaatgggtt agaggcgccc gtttaactga 489961 acctgtttca aacgtgaaaa tgcttcaatt tgagcaagga ggcagtgctt tttctccagc 490021 tgccctgaac caggagatgt ttccgcagga agcgtcacag caaaatgaag ccatcgacgt 490081 cgtattcccg ctcctccacg gaccgaacgg agaagacggt acgatccagg gaatgctcga 490141 gctgttgaac attccttatg tcggcaacgg agtgcttgct tcctcagctg gcatggataa 490201 agttgtcatg aaacatttat ttgcgcaggt tggccttgct caggctaaat acgcagcttt 490261 ccttaagaaa gactggactc gttctccgaa agaaagctgt gaggaggttg aacaggaatt 490321 aggctaccct tgcttcgtaa aaccggcgaa cctcggctca agtgtcggaa tcagcaaatg 490381 ccgaaaccgt gaagaactgc aaaaagcgtt tgagcttgct ttccaatatg accgcaaagt 490441 cgtcgttgaa gaaggaatta acggccgcga gatcgaaatc ggcgttcttg gaaatgatga 490501 tcctaaatgc tctgttgtgg gagaaatcgc accgaagaca gatttctacg attacaaagc 490561 gaaatatgag gatggagata ctgatctgat gattccggcg attgtgactg atgaggaata 490621 cgcaacaatc agtgatatgg cgatcaaagc gtttaaagcg atcgacggtt caggactcgt 490681 cagagcggac tttttcctga cagctgacgg cgaagttctg atcaatgaag tcaacacaat 490741 gcctggcttt acacctttca gcatgttccc gttgctctgg aaagaagccg gagtggaata 490801 tgctgacctg attgaacagc ttgtggagct tgcaaaagaa cgccacgctg aaaaacaatt 490861 gattaagcat acattctaat gaagaaggac actgccggta aaagggcagt gttttttccc 490921 gtatatacaa aagaaagaga gggaccttac ttgattaagc gaacagtaaa aaacattgcc 490981 gaaatggtta aaggcacact agcaaatccg caatatgaac aaacagtcat tcatggagtg 491041 gcaaccgata caagaaaact ggaacaacat cagctcttta ttccgctgaa aggggaacgt 491101 tttgacggcc actcttttgt ggagcaggcc tttgaagctg gtgtagcggc tgttctttgg 491161 gatcggtcag taccaaatcc gcccgagaat cacgccgtca ttttagtgga cgataccctt 491221 actgcacttc agcagcttgc aaaagcttat ttgcaggagc ttggcacgcg tgtcatcgga 491281 gtaaccggaa gcaatggcaa aacgacaaca aaagatatga ttcacgccgt attggggacc 491341 cagtaccgtg tccacaaaac tggaggaaac ttcaataatc atatcggttt gccgctgacg 491401 gttttagcga tgcctgaaaa tacggagatc gccgtattgg agatgggaat gagcgccaaa 491461 ggagaaattg acctcttgag ccgactggca aacccggatg cggcagtgat tacgaatatc 491521 ggcgaatcgc atatgcaaga cctcggctct agagagggca tcgcggaggc gaagcttgaa 491581 atcataaacg ggcttaaaga agacggagtg ctgatttata tcggggacga accgcttctt 491641 caaaatgcat acagctgcca gacgaaaacg tacggtacgg gaacgcataa tgattatcag 491701 cttcaggatg tcagccagag tgaggaagga acccatttta caatcaaagg gatagaaaac 491761 acgtttttta ttccaatact cggcaagcac aatgtgatga acgccatggc tgcaattgct 491821 gcaggggctt attttggcat cgcgcctgag gatgcggcaa aaggactgag cggcctaaag 491881 gtaaccggga tgaggcttga actcatcaaa acagacagcg gcctttcgat aatcaatgac 491941 gcttataatg cgagcccgac ttccatgaaa gctgcaattc aattgacaga aagccttgaa 492001 ggctacggca aaaaaatgct cgtgctcggt gatatgcttg aactcggcga tcttgaagaa 492061 acgttccata aagagtgcgg cgctgtgatc agccctgata aaattgaccg cgtctttacg 492121 tacggaaaac tgggagcttt tatcgcggaa ggcgccctga aacactttga gaaagaccgc 492181 gtcagccatt acactgagaa aaaagatctc cttcaagctg tgaaggaaaa cgcatcaaaa 492241 ggcgatttga ttttattcaa agcgtccaga ggtatgaagc ttgaagaaat cgttaaagat 492301 ttaatagaga gcccgctttc ataagaaaat attttgcgaa aaaacgcata ttgcatcata 492361 aaataacctg atatgcaaac actaatgtat gccggccgaa aattatgtat atctggccgg 492421 ctgcggctat gatacaatat atataggtta tttcgcgata cgaacatatt cgtccggact 492481 tttcatcgtg acccgaagtt ctccgctgga ttcttgggag cggatggagc agcagccggc 492541 atattcgaga tgccgatctg cttctcatct tattgaaaaa caaatagtgt aatggtaaga 492601 taaaacttaa agtaattcgg gctttgtata cggatggatc ctgtccttct tgtctaaagg 492661 gcagttttat aagtggtaaa tcacgacatt actgaaacag caattagaag gagtttgaat 492721 aatttgacta taacgtttca agattttaat ttaagttctg atctcatgaa agcaattaat 492781 cgtatgggat ttgaagaagc aacaccgatt caggcacaaa cgataccgct cggactttca 492841 aataaagacg tcattggaca agcgcaaaca ggtacaggta aaacagctgc gtttggtata 492901 ccccttgttg aaaaaattaa ccccgagtct cctaatattc aagcaatcgt aatcgcgcca 492961 acccgtgaat tagccattca agtatctgaa gaattgtata aaatcggaca agataaacgt 493021 gcgaaggttc ttcctattta cggcggacag gatattggac ggcaaatccg ggcgttaaag 493081 aagaatccga atattattgt cggaacacct ggacgtcttc ttgaccacat caaccgccgc 493141 accattcgtt taaacaatgt aaataccgtt gtaatggatg aagcggatga aatgctgaac 493201 atgggattca ttgacgatat tgaatctatc ctttcaaacg tgccaagcga gcatcagaca 493261 cttctgttct ctgccacaat gcctgcgccg atcaaacgca ttgcagagcg cttcatgact 493321 gagccggaac acgtaaaagt aaaagcgaaa gaaatgacgg tttctaacat tcagcagttc 493381 tatttggaag tgcaagaacg taaaaaattc gatacactga ctcgccttct tgatattcag 493441 tctcctgagc ttgcgatcgt attcggacgt acaaaacgcc gtgtcgatga gctggctgaa 493501 gctctgaacc ttcgcggata tgcagctgaa ggtattcacg gtgacttaac gcaggcgaaa 493561 cgtatggttg cgcttcgtaa atttaaagaa ggcgcaatcg aagttctagt cgcaactgat 493621 gttgccgctc gcggacttga tatctcaggt gttacacacg tatacaactt cgacgtgcct 493681 caagatcctg aaagctacgt tcaccgtatc ggaagaacgg gccgtgcagg aaaaacaggt 493741 atggcgatga cgttcattac accgcgtgag aaaagcatgc ttcgcgcaat tgaacaaaca 493801 acaaaacgca aaatggaccg catgaaggag cctacacttg atgaagcgtt agaaggtcag 493861 caacaggtta ctgttgaacg tcttcgcaca acaatcagtg aaaacaacct gaacttctac 493921 atgacagcgg cagctgagct gcttgaagat catgatgcag taacagtggt tgcggcggct 493981 atcaaaatgg ctacaaaaga gccagacgac acaccggttc gcttaacaga cgaagcgccg 494041 atggtcagca aacgctacaa gaaccagcgc tcttctaaac gcagagacgg tcaaggcggc 494101 ggctaccgcg gcggaaaagg gaaaagcaac aaccgttctt cctatgacaa aaagcgttca 494161 aacgatcgcc gttcttcagg tgacagacgc cagaaaaaat cttactaatt tgatcgattc 494221 agagcccaaa acatgatgtt ttgggctttt ttatgttcgt gatttgttat tcagcaaact 494281 ttcagctgac ggaagccatt tttctctgta tgcttaagaa tgaaaccttt ctgtaaaaga 494341 gacgtataaa taacgacgaa aaaaagggag gtaggtattt ttgagagagc agccaaaaaa 494401 ccaaatcagt ccagacggat taaaggtttg gcgacttcaa gagatcatca tatccgctgt 494461 ttgcttgctt attgtcattg cagttgcagt gttaagctat tattttcatt ggccgtactg 494521 gatcagcggc gtgctcggcg ctgtttggct gctgggatcg attgtgacgg tctttatcat 494581 tccgaaggtc cgtcataagg tgtggcgata tgaagtccat gaacatgaaa tagatattca 494641 gtcaggtatt tttgtggtga cacgtgtgat tgttccgatg gtcagagttc agcacgtcga 494701 tacgtcacaa gggccattat taaaaaaata caacctggca acggtgaaaa tttccacagc 494761 cgcgaccgtt cattcgatcc ccgctttaga gatggaggaa gcggatcggc taagagactc 494821 catttcccgt ctggcgaggg tgactgacga tgatgtctga accgaaacgc ctgcacccgg 494881 tggcagtcat tttgaattta tgccatacca ttattcaaac gataaaaaat atcattctgc 494941 cattcttttt tgtgtatatt gtcaattcaa accatactgt ccgtttttac ggagccattg 495001 cgctcggtgt gctgttcatc tggcttgtag cggcaagcat tatcaaatgg agaaggttta 495061 cctatcgaat tgaagatgat gaatttagaa ttgaagaagg cttatttgtt acgaaaaaac 495121 gatacatatc gattgatcgg attcaaacaa tgaatacgag cgcgggcctt gtccagcaaa 495181 tctttaagct tgtgaagctg caaattgaaa cagcaggcgg aggcaaggag gcagaagccg 495241 ttctttctgc tatttctgtt gaagaagcgg aacgcatcaa agaagctgtc tttaagaaaa 495301 aagcgcaaag acgagaaaat gaacttgatg aagaacggct tgaagctgaa gaggagttgg 495361 atccgtccgt tgaggtgcaa gagcactatc gcatgaacgc gaaagaattg ctcatggccg 495421 cttctacctc cggcggaatc ggagtcatta tctccgctgt atttgcactt atttcccagc 495481 ttgatgaagt gctgccgatg gattggttat tcgataaatt ttccttcctt cagcacgcca 495541 gcatcggtat ttatgcggta ctcattttta tcggtttatt tatcgcctgg attttcagca 495601 tcgcgggcat gatgtttaga tacgcgaact ttcaaatcat aaaaaaagag caggaactgg 495661 tgatttcaag gggaattatt gaaaaacatc aagtcacgat tccgctgcga aaaatacaag 495721 ccattaaaat caaagaaaat atcattcgcc agcttttcgg ctttgtaacg gtgtccatcg 495781 tcagcgcagg aggcggcgac cgggaaaaag aagaaggcgc tttgaccatt ctctttccaa 495841 tgattcataa aaaaaagctt ccgcacatgc tccgaacatt tacgccggaa tacacgctgg 495901 aagaaaactg ccgccgcctg ccgcggcgcg cgttgaaacg ctatttgttc cgttctgtca 495961 ttttttcact ctttttgatc atcccgttat gtatcttctt tcagccatgg ggctatctgt 496021 cagtgatcct gctgccgata gaattgctct tcggctatct cgcgtataaa gaggctgcat 496081 ggacgatcaa cggggaccgt cttcagctga cgtctagatt tataggcaga acaaccgcca 496141 ttgtactgaa aaaacgaatg caggtctgca agttcagcca atcctatttc caaaagaaag 496201 gccgcttgta taccatttct acttcggtga aatcatcgag ccatatggaa gagttaacgg 496261 tgagggacgt aggtgaagag gatgcagcct tcattttaaa gtggtactca tatgaaaaag 496321 cggacggtta ataccgccgc tccagcgtgt cggcaaaccc tcgcattcgt tgtcaggact 496381 gcgcttcggt gctcaatgcg aagtggatca acggctaaat tctcaggcgt cctgcctaaa 496441 cgccgtcgtc atcacatcct gtgaaagtcc gctcctatgc tcgtccttcc tagacttcat 496501 gggttttcaa tcacgctgaa aagatgacaa aatcctaaaa tgaaaaccat tttaggattt 496561 tgtcaacaat ctgaagcggc ggttaatacc gccgctcttt tttttgcacg cataaaaacg 496621 aaagaagaaa cccgccgcat agtccaaaca aatgggccat catgttaata ttggagttga 496681 taaacgacat gagaacggca aatgcgagca gtgtgatgat cattttggaa tgctcctgcc 496741 caattaactc attgcgaaaa agaaccataa acaggtatac gccaaatagc ccgaaaatgg 496801 cgcctgaagc cccgacatgc acgtaatcaa gcggctctgt aacataagtg ccgatattgc 496861 cgatgatgcc ggagccggcg tatacaagaa ggaaacgcgc ttttcccagc atgcgttcca 496921 aagccggggc aaataaaaag atggacatgg aattaaacag cagatgtgtg aaaccggcgt 496981 gcagcaaaat cggtgtgata agccgccacc attcaccgtt tgcgacacct agattatagc 497041 ctgtgacggt atccctccat aacacgactg aatgggcagg aagtgaaaaa aacagccaga 497101 gaacagcttg caaagccaat ataaaggtga caacggggta aagcctgata aatgtttgaa 497161 aattttcagt ccgtataaac attccgagcc ccttttcttc attttggtat atctatagta 497221 acacgtttat gagacaaacc atttaaatag tacgtacgca aaggaggtta tcatacatga 497281 tttacggcat tgggctggac attaccgagc ttaaacggat cgcctctatg gctgggcgcc 497341 agaaaaggtt tgccgagcgg attttgacgc gaagcgagct tgaccaatac tatgagcttt 497401 cagagaaaag aaaaaacgaa tttctcgcgg gcagattcgc ggcaaaagaa gcgttctcga 497461 aagcatttgg caccggcatt gggaggcagc tcagctttca ggacattgaa attaggaaag 497521 accaaaatgg caagccctat atcatttgta cgaaactgag ccaggccgcc gttcacgtat 497581 cgatcactca tacaaaagaa tacgctgccg cgcaggttgt gattgaaagg ttgtcaagct 497641 agtctgcata ttagggaaac cccactcata tatttgatag tgcattaagg gagacaagtt 497701 gtttgaggct tttatggtac gcatctgttc tgcctaaacg tgtaccgagc gtaccgttaa 497761 agtcaaacaa gcgatttctt ccttttacat caattgagaa aaaggggttg aaaaaggtga 497821 gaaaaagctt tgttttgctt ttaacgggac tgcttgctgt tcttattctt tctgcctgcg 497881 ggcaaaaaac acagcaagat attgtggccg ggttagatga aaaggcgaaa gaatacacct 497941 cgtacaaagc aaaagcgaaa atgaccatcg agacagggag tgagcctcaa gtatacaatg 498001 tggaaatctg gcacaaaaag ccgtctctgt acagggttta tttagaaaat ccgaaaaagg 498061 accaaaacca agtcatttta cgaaatgaaa acggagtatt cgttctcacg ccgtctttaa 498121 ataagagctt cagatttcaa agcgattggc cgaacaacag cagccaggtt tatctgtttg 498181 aatcgctcgt aaaggatgtt caaaacgatt cggatgcagt tttcacagcg aaagaaaaga 498241 aatacgtatt tgaaacaaaa acaaactatc agcataacaa aatgctgccc acgcaagaaa 498301 tcacatttaa caaaaaagat atgagcccgt catctgtcaa agtgatggat actgaccgga 498361 aagtgatggt caaagtagaa ttcagcagct ttgaatttaa taaacaattt gataaagaat 498421 catttgatga aaagaaaaat atgacccttt ctcaaatgga tgtcgccaca agcgcaaagc 498481 cttccgatac atttgcggtc aaaacgccgc tggaactgcc gcttggcgtc aagctgcttg 498541 aagaaaaaga tatatctact gaagacggga agcgcatcat catgacgtac ggaggagaaa 498601 aatcatttac gttaattcag gaaaaagccc agattgccaa ggcttcctcc tccgttacgc 498661 tgaacggcga accggtaaat ctcggctaca ccatcggcgc cctgtcggat gcatcattat 498721 catggacata tgacggcgta gattaccttc tctcttctaa agatctttct aaagaggaaa 498781 tggtgacagt agcgaaaagc atgcagggac aatcatcgaa ataaccgcca aaggccaaac 498841 atgatttggc ctttttttcg ttagacatcg tttcccttta gcctttaatt ttagtatgat 498901 atgtaaatga tattgaataa aagctaggaa gtgtcgtaat gagcacaaaa cctttttaca 498961 gagatacgtg ggcggaaatt gacttgtccg cgataaagga aaatgtcagc aatatgaaaa 499021 aacatatcgg tgaacatgtc cacttgatgg cagttgtgaa agcaaacgcc tacgggcatg 499081 gtgatgcaga aacagcaaag gctgctcttg acgcaggtgc ttcatgcttg gccgtggcca 499141 ttttggatga agcgatttca ctgcgcaaaa agggattgaa ggcgcctata ttggtgcttg 499201 gcgcggttcc cccggagtat gtggcaatcg ctgctgagta tgacgtgacc ttaacaggtt 499261 attctgttga atggcttcag gaggcagccc gccacacgaa aaaaggttct cttcattttc 499321 atctgaaggt cgatacgggg atgaacagac ttggtgtaaa aacagaggaa gaagttcaga 499381 acgtgatggc aattcttgac cgcaaccctc gtttaaagtg caaaggggta tttacccatt 499441 ttgcgacagc ggatgaaaaa gaaagaggct atttcttaat gcagtttgag cgctttaaag 499501 agctgattgc tccgctgccg ttaaagaatc taatggtcca ctgcgcgaac agcgccgctg 499561 gactccggct gaaaaaaggc ttttttaatg cagtcagatt cggcatcggc atgtatggcc 499621 ttcgcccgtc tgctgacatg tcggacgaga taccgtttca gctgcgtccg gcatttaccc 499681 tgcattcgac actgtcacat gtcaaactga tcagaaaagg cgagagcgtc agctacggag 499741 ccgagtacac agcggaaaaa gacacatgga tcgggacggt gcctgtaggc tatgcggacg 499801 gctggctccg aaaattgaaa gggaccgaca tccttgtgaa gggaaaacgc ctgaaaattg 499861 ccggccgaat ttgcatggac caatttatgg tggagctgga tcaggaatat ccgccgggca 499921 caaaagtcac attaataggc cggcaggggg atgaatatat ttccatggat gagattgcag 499981 gaaggctcga aaccattaac tatgaggtgg cctgtacaat aagttcccgt gttccccgta 500041 tgtttttgga aaatgggagt ataatggaag taagaaatcc tttattgcag gtaaatataa 500101 gcaattaact tacctaaatg gagaattcat aaaacagctt tgcttgaaga gtgaataatg 500161 gtatcattat cactggatgg ataaaagagt cgtatccgta agtttggtgg aggtgtatgt 500221 tttttgtctg aatccagcgc aagaaccgaa atgaaaatca gcttgcccga aaacctagta 500281 gctgaattgg atggtgtagc gatgcgggag aaacgaagca gaaacgaact gatatcacaa 500341 gcagtgagag cgtatgtcag cgaacgaaca actcgtcaca accgtgattt gatgagacgc 500401 ggctatatgg aaatggcgaa aatcaacctg aatatttctt ctgaggctca ctttgcggag 500461 tgcgaggctg aaacgacagt tgagcgctta gtcagcggag gataatcatt tgattgtgaa 500521 acgcggcgat gtttattttg ctgatttatc tcctgttgtt ggctcagagc aaggcggggt 500581 gcgcccggtt ttagtgatcc aaaatgacat cggaaatcgc ttcagcccaa ctgctattgt 500641 tgcagccata acagcacaaa tacagaaagc gaaattacca acccacgtcg aaatcgatgc 500701 aaaacgctac ggttttgaaa gagattccgt tattttgctg gagcaaattc ggacgattga 500761 caagcaaagg ttaacggata agattactca tctggatgat gaaatgatgg ataaggttga 500821 tgaagcctta caaatcagtt tggcactcat tgatttttag acatatttgc aggttgctca 500881 aatagagcaa ctttttttgt tttcaaaaaa cataaacgat ataatagtga aataacgaaa 500941 aaatatgttg ttttttattg ggaggtaagc gaatttgatg tcgaaccaga ctgtatacca 501001 gttcattgcc gaaaatcaaa atgaactgct ccaactgtgg actgacacac taaaagaatt 501061 aagcgagcaa gaatcctatc agctgactga ccaagtgtat gaaaatatat ctaaagaata 501121 tatcgacatt ctgctgctgt ctgttaagga cgaaaatgct gctgaaagcc aaatcagcga 501181 actggcgctt cgagcggtcc aaatcggact gtctatgaag tttttggcta ctgcacttgc 501241 cgaattctgg aagcgtctct acacgaaaat gaatgataag agattgccag atcaagagag 501301 cacggaatta atctggcaga ttgatcgctt tttcagcccg attaacacag aaatttttaa 501361 tcaatactca atctcatggg aaaaaacagt atccctgcaa aaaatcgcgc tgcaagagct 501421 gtctgcgccg cttatcccgg tgtttgaaaa tatcactgtg atgcctcttg tcggaacaat 501481 tgataccgaa cgcgcgaaac gaattatgga aaaccttctt aatggcgtcg tcaaacaccg 501541 ttcccaagtc gtgctgattg acattacagg tgtccctgtc gtcgatacga tggttgccca 501601 tcatattatt caggcatcag aagctgtaag gcttgtcgga gcaaaatgcc tgctggccgg 501661 aatccgtccg gaaattgctc aaacaatcgt caacctgggg attgatttat cccaagttat 501721 aactaagaat accctgcaaa aaggaattca aacagcattg gaaatgacgg atcgaaaaat 501781 cgtttcattg ggggaataac attttgagac atccgaaaat cccgatcttg aaactgtata 501841 attgcttatt agtgtccatt cagtgggaac ttgatgacca gacagcatta acttttcaag 501901 aagacttatt aaataaaata tacgaaacag gtgctaacgg agtcgtcatt gacctgacat 501961 ctgtggatat gattgattca tttatcgcga aagtgctggg ggacgtcatt acaatgtcta 502021 agttaatggg ggctaaagtc gtcttgaccg gcattcagcc cgctgtggca gtgacgctga 502081 ttgaacttgg aatcgcgctt gaggaaatcg aaactgcgct cgacttagag caggggcttg 502141 agacattgaa gcgggaattg ggggaatagc gaatgaacga ccaatcctgt gtaagaatca 502201 tgacagaatg ggatattgtg gccgccagac agctgggacg aaacgttgcg aaagaactgg 502261 gtttcggcac ggtagaccag gctagaatta caacggctat ttcagaatta gccaggaata 502321 tttatttata tgccggcaaa gggcagattg gaattgaaca ggtcgcagac agaggaaaaa 502381 aaggcctgaa aatcatagcg gaagaccaag ggccgggaat tcctgatatc cgaaaagtca 502441 tggaagacgg gttttcaacg tctggaggac ttggtgcggg acttcccggg gtcaaaaggc 502501 tgatggatga attcagctta aattccgtag cgggggaagg aacagagata caagccatca 502561 aatggcttcg gtaggaggta agaacgtgga ttttagggag gttattgagc agcggtatca 502621 tcagctgctt agtcgatata tagccgaatt aacagaaaca tctttatatc aagcccaaaa 502681 attcagccga aaaacaatcg agcaccaaat tcctccggaa gaaatcatca gcattcacag 502741 aaaagtgctg aaggagctgt atccaagtct cccggaagat gtgtttcatt cgctggattt 502801 tttaatagaa gtcatgattg gctatggaat ggcttatcag gagcatcaaa cccttagagg 502861 gatacagcag gaaatcaaat cagaaattga aatcgcggca aatgtccagc agacgcttct 502921 cggaactaaa gttcctcagg aggaagcgct ggatatcggc gccatcagtg ttcccgctaa 502981 acagatgagc ggtgattact accactttgt caaagacaag gaatccatca atatcgcaat 503041 cgcggacgtg atcggaaaag gcattccagc ggctttatgc atgtccatga ttaaatacgc 503101 aatggactct ttgccggaaa cgggcataca cccttctcaa gtgctgaaaa atttgaatcg 503161 tgttgttgaa caaaacgttg atgccagtat gtttattacg atgttttatg cgaattacaa 503221 tatggacaag catcaattta catatgcttc agcgggacat gaaccgggat tctattattc 503281 tcaaaaagac aacacgtttt acgatttaga ggccaaagga ctcgttctcg gcatctcgca 503341 ggactatgac tacaaacaat tcgatcagca tctggaaaag ggcgatatga ttgttttatt 503401 ttctgacggc gtcacagaat gcagaacgga aaacggtttc ttggagcgtc ctgatctgca 503461 gaagctcatt gaggaacata tgtgttcctc tgcgcaggaa atggtcaaaa acatttatga 503521 cagcctcctc aaattgcagg attttcagct tcacgatgat tttacgttaa ttgttttgcg 503581 gagaaaggtt taacgtctgt cagacgaggg tataaagcaa ctagtgattt gaaggaaaat 503641 ttgaggtgat acgaatgaat ataaatgttg atgtgaagca aaacgagaat gatatacaag 503701 taaacattgc aggagaaatt gatgtatact cagccccggt gcttagagag aagctcgttc 503761 ctctggcaga acaaggagct gacttaagaa tttgcctgaa agatgtcagc tacatggaca 503821 gtaccggatt gggcgttttt gtagggacct ttaaaatggt gaaaaaacaa ggtggttcgc 503881 tgaaacttga aaatctttct gaacggctga tccgactgtt tgacattaca ggcttgaagg 503941 acatcattga tatttctgca aagtcagaag gtggagtgca atgaagaata atgctgatta 504001 catcgaaatg aaagtgccgg cccaacctga atatgtggga attataagac tgacgctgtc 504061 aggggtcgca agcagaatgg gctatacgta cgatgaaatt gaagacttga aaatcgcagt 504121 cagtgaggcg tgcacaaatg cggttcagca cgcttacaaa gaagataaaa atggggaagt 504181 gtcaatacga ttcggtgtgt ttgaagaccg tttagaggtt attgtggcgg atgaaggaga 504241 cagctttgac tttgatcaaa agcagcagga tctagggccg tacacacctt cgcacacagt 504301 tgatcaatta tcagaaggag ggctcggtct atatttaatg gaaacgctca tggatgaagt 504361 cagagtgcaa aaccactccg gcgtcaccgt agcgatgaca aagtatttaa atggggagcg 504421 agttgatcat gacacaacca tcaaaaacta cgaaactaac taaagatgaa gtcgatcggc 504481 tcataagcga ttaccaaaca aagcaagatg aacaagcgca ggaaacgctt gtgcgggtgt 504541 atacaaatct ggttgacatg cttgcgaaaa aatactcaaa aggcaaaagc ttccacgagg 504601 atctccgcca ggtcggcatg atcgggctgc taggcgcgat taagcgatac gatcctgttg 504661 tcggcaaatc gtttgaagct tttgcaatcc cgacaatcat cggtgaaatt aaacgtttcc 504721 tcagagataa aacatggagc gttcatgtgc cgagacgaat taaagaactc ggtccaagaa 504781 tcaaaatggc ggttgatcag ctgaccactg aaacacaaag atcgccgaaa gtcgaagaga 504841 ttgccgaatt cctcgatgtt tctgaagaag aggttcttga aacgatggaa atgggcaaaa 504901 gctatcaagc cttatccgtt gaccacagca ttgaagcgga ttcggacgga agcactgtca 504961 cgattcttga tatcgtcgga tcacaggagg acggatatga gcgggtcaac cagcaattga 505021 tgctgcaaag cgtgcttcat gtcctttcag accgtgagaa acaaatcata gaccttacgt 505081 atattcaaaa caaaagccaa aaagaaactg gggacattct cggtatatct caaatgcacg 505141 tctcgcgctt gcaacgcaaa gctgtgaaga agctcagaga ggccttgatt gaagatccct 505201 cgatggagtt aatgtaatga tccaggttga agaaaacgag catattcaaa ctctagtata 505261 tcaactgaat aaagaaggga aatcgatttg cggtgacagt ttttttatga aagctgatga 505321 taaggagtta atttgcgcgg ttgctgacgg actgggaagt ggatcacttg ctaacgaatc 505381 ctctgcagcc atcaaagact tagtggaaaa ctatgcgagt gaagacgtag aaagcattat 505441 cgaacgctgt aatcaggcga tgaaaaacaa aagaggcgct acagcatcta tcctgaaaat 505501 caattttgag caaaggcagt ttacgtactg ctctgtcgga aatgtacggt ttattctgca 505561 ttccccgtct ggtgaaagct tttatcctct gccgatttcg ggctatttat caggcaagcc 505621 gcaaaaatac aaaacgcaca ccgccaccta tgaaaagggt tcaaagttca ttatacatac 505681 agatggactc aacgtacctg atatccgctc ccatttgaaa aaaggccaat cggtagaaga 505741 aatatcgaat tcgctgaaaa tgtatacgac atcgagaaaa gatgacctga cctatattct 505801 cggacagctg tcctaaaaaa ccagaaaaag aagctggaca tccggcttct tttttttgcg 505861 gttgactatt aataagtgcg cttattatac ttaataagtg aacttatcat tctgggagct 505921 tatgggatgt ggaattatga atacacagcg atagctgatg tggatgtggg aaaacctgga 505981 actgttatca ggaaacagaa acaatggatc aatgggagac gggtattgca tcagattctt 506041 tgaaaggaca atttcaaaat ggaacggaag gaacattgct tctgcaagga aaaacaattc 506101 tcttatggct tgagcatgtg gagaaacatc gggcgttttc tgtcatggtc aacatgcccg 506161 catagcaatg taataatgga gttttttcac gtgcttcaaa agcaaaaaga agatttgtgt 506221 atcacatatg gaattgtatt agaaggcgct gaagcaaaaa agtggggaga aatcattggg 506281 actgaactgt ctaaagacat gccgacggct gtcagcaggc ttgtccatct ttacggagga 506341 gtgataaaat gaacacaaat tactggatcg gcgttgtgtc agagcaacat gtattaaaag 506401 gcgctgccgg cggttttgca cagctgtgcc atggaaaaaa agccccgctc gccaaaatga 506461 aagagggaga ttggctgatt tattattctc cgagagacgc atatccagac ggcaaactgc 506521 tgcgaagctt tactgcgatc ggcaaagtaa aaagcggaaa catctatccg tatcaaatgg 506581 ctccgaattt tattccatac cgattagata tagactatta tccatgccat aaaatcggtt 506641 tttacgacat taaatcaaag cttgaatttg ttcaggaaac caagcatctt ggctttttat 506701 ttcgcagagg acactttgaa ataagcaaaa aagatttttt gacaatagca caagcgatgg 506761 gagttaacat aagtggaatg gcactctaaa tttagcggtc cgaacacaag cccgggcttt 506821 ttattatggc aggccacgca aagttggcag cggaaagtag gaaaagcatt ggctgagttt 506881 gacctgaccc acgttcaatt tgttctgctg acctcgtgca agtatatgat tgctcacgga 506941 gaaaccgtca cgcaaaaaaa acttgcaagc ttcagccaga ccaatatcat gatggtttcg 507001 gaggttgtgc ggacgcttga gaaaaaagga tttatcgaaa gaagcaaaaa tccccaggat 507061 aaaagagagg tcctcctgtc tcttacagaa ataggaggag aaaaagtaac agcggctttg 507121 ccaattgttg agaagattga tcaagccttc tttgcagctg cgatgaaaaa agagaatttt 507181 ctgagcggct tacaggaact attgaaacat gagtaaagat acgggcagcg ccagctgtct 507241 ttttttatgt gtttttttcg gtttttgata cactagagaa agaacgacaa aattggaggc 507301 tttggttaca tggaaacgtc agccctttta aaacagcaaa ttgcgaaaga aataggttta 507361 tcacaaaaac acgttgaaag tgtcatccgc ctgcttgagg acggcaatac agtcccgttt 507421 attgcccggt atcgaaaaga gcagacgggt tcaatggatg aggttcagat tcagacgatt 507481 tctgaacgct ggcaatacat acaaaacctg aatcagcgaa aagaagaagt catcaggctg 507541 attgcagagc aggataaact gacagataat ctaaaacgta aaatcgagca atcggtgaag 507601 cttcaggaag tggaagacct ttaccgccct tataaacaaa aacgtaaaac aaaggcgaca 507661 gtcgccaaaa gcaaaggcct tgagccgctt gccgactata tcctgacact tccccaagat 507721 gatcatctgg cagcaactgc agaccaatac atcagcgaag aaaaagaagt gttcacacga 507781 gaagaagcga ttgaaggcgc caagcacatt attgcggaac aaatctcaga cgagccgacc 507841 ttcagaaagt ggattcgcca ggaaaccttc aaaagaggaa ccattaagtc tgcagccgga 507901 aagtcggcag acaccgatga gaaaaatgtg tatgaaatgt attacgagta tgaagagcca 507961 attgcaaaag ttgttccgca tagggtgctg gcaatgaacc gcggcgaaaa agaagacatt 508021 ttaaaggtag cgatcgaacc gcctgcggat cacattaagg cgtatttaga aaaacaaatc 508081 atcaaaaatc gctcaacatc cgtaagagag attttgcagg agacaattga agacagctat 508141 aaaaggctga tccagccggc aatcgagcgt gaaatcagga aagagctctc agaaaaagct 508201 gatgaacagg cgattcatat tttctcagag aacttgagaa agcttctttt gcagccgccg 508261 atgaaaggca aaaccgttct cggtgttgac ccagcctttc gaactggctg taagctcgct 508321 gtgtcagatg agaccggaaa agtcttgaaa attgatgtga tctatccgca tgcgccagtc 508381 aacaaaacaa aagaagccca tgaaaaagtg aaaaagattc ttgagcagta tcaagtcgag 508441 atggtggcga tcggaaacgg cacagcatcc agagaaacag agcaattcat cgtcaatgta 508501 ctcagagaca tgccgcgcaa aatttattat gtgatcgtca atgaagcggg agcaagcgtc 508561 tattcggctt cagagcttgc cagagaagaa ttccctgacc ttaaggttga agagcgcagt 508621 gccgtatcta ttgctcggag acttcaagac ccgctcgcgg agctcgttaa gatcgatccg 508681 aagtctgttg gtgtcggaca gtatcagcat gacgtcagcc aaaaacgctt aaatgaatct 508741 ctgcggtttg tcgtcgaaac tgtcgtaaac caggttggag taaacgtcaa cacagcctcc 508801 gccgcgctgc ttcaatatgt agctggatta tcgaagtctg tagcaggcaa cgttgtcaaa 508861 aaacgtgagg aaatcggaaa gttttcaaat cgaaaagaac tgaaggacat cccaaggtta 508921 ggtgcgaaaa cctatgagca atgtatcggt ttcttaagag tgcaggaagg gacagagcct 508981 ttggatagaa caggcatcca cccggaaagc tataaagaaa caaaagcact tttgaaaaaa 509041 ctcggacttt caacagaaca tatcggcacg gcggaattga aggacaaaat caatcagctg 509101 gcgctctctg aaacggcaaa agagctggga atcggcgaaa tcactctgaa agacatttgt 509161 gaacagctga caaggccgga acgcgatcca cgcgataagg tgcctaagcc tttgctgaaa 509221 acagacgtcc ttcagctgga agatttgaaa gagggaatgg aactgcaggg caccgtgcgc 509281 aatgtagtgg acttcggagc gtttgttgat atcggagtca aacaagacgg gcttgtgcat 509341 atctcaaaat tgagcaatca attcgtcaag catcctcttg atgtcgtatc tgtcggcgat 509401 attgtgacag tttgggttga cggcgtagat gtacaaaaag gcagagtatc gctgtctatg 509461 gtaaaataaa agcactgctt acgagcagtg ttttttccta tagaaatacc agcattgatt 509521 cagcagttta atttggtaat tatctttttc aaggaacgct ttttgcatct gctttttaag 509581 ccaatttggc ataggctcat tcctcctcag cttttatcat aagagggaca gtgattacca 509641 tattgtatgc gaacggtgaa ttgtcccgtt caatgttttt taagtgaggt gcaccatgga 509701 taacaaagag cttcaaaagc tgacagagga tatttctgaa acatatttta aaaagccgtt 509761 ccgccatcag gcgcttttta atgaccggct taaaaccact ggcggcaggt acctgttaac 509821 ctcccataac attgaattga acagaaaata tttgattgaa cacggcaggg aggaactgat 509881 tggcatcatc aagcacgagc tctgccatta tcatcttcat cttgaaggaa aagggtacaa 509941 gcacagagac agagatttta gaatgctatt gcagcaggtc aacgcgccga ggttctgtac 510001 accccttaag aaaaaagcgg aaaacaaaaa aacttatatg tatatctgta cgacctgcgg 510061 ccaacagtat ataaagaagc gcgccatgaa ccctgacaga tacagatgcg gaaaatgccg 510121 cggaaaaata aaaagaattt tttcgtgaaa aaggttgacg aatatggcaa gcctatgtta 510181 cattataaaa gtcgtcacga gagataaata aaaacattta cctcttgaca ctgcaaatca 510241 aggctgatat aataagtctt gtctcattat tccacagtag ctcagtggta gagctatcgg 510301 ctgttaaccg atcggtcgca ggttcgaatc ctgcctgtgg agccatattg gagaagtact 510361 caagtggctg aagaggcgcc cctgctaagg gtgtaggtcg cgtaagcggc gcgagggttc 510421 aaatccctcc ttctccgcca taagatttcg atataagttc tcaaccatcg gcccgttggt 510481 caagcggtta agacaccgcc ctttcacggc ggtaacacgg gttcgaatcc cgtacgggtc 510541 attccatttc gttgggctat agccaagcgg taaggcaacg gactttgact ccgtcatgcg 510601 ttggttcgaa tccagctagc ccagccattt ttatttttga aatctaatag taagagccat 510661 tagctcagtt ggtagagcat ctgactttta atcagagggt cgaaggttcg agtccttcat 510721 ggctcaccat ttgtcttttt gcgggtgtgg cggaattggc agacgcgcta gacttaggat 510781 ctagtgtctt acgacgtggg ggttcgagtc ccttcacccg cactttattt acaaagtgca 510841 cgcaaatctg ttttactagg ttaagagcct actaaaccag cacaacacaa tttaatgatc 510901 acgcggtcgt ggcggaatgg cagacgcgct aggttgaggg cctagtgggt gaataacccg 510961 tggaggttca agtcctctcg gccgcatctc aataatacca agggtttaac cacctttggt 511021 attatttttt tgtgtggaaa atacggctat gggagaagac ttgctcacca aaactcacca 511081 gttacttaaa gtaagtcatc caaacggtcg gcggttcctt ctgtttatta ggaaaaagat 511141 atccgttcat tgtaaaagaa acgaaccatg tcctattcgt tcaaaaaaac taaagggtga 511201 tacatattat acatgattaa tatgtatcac ccttttcttt cttgttcaac aatcgcgctt 511261 gaggagaaca taagctaata caactgactc gatttctaaa gttgctccat tcttttttta 511321 aacaactcat ccacaacctg ttttaaaatc tcgtacgact gaatttcctt gctcaattcg 511381 taaatattag ataacacaat taattcatct gcgtgataca tttgttggaa atcaattagt 511441 tcgcgacgaa ttgtttctcg atcacccatg attgtatacc ccagtcgact gtggagaatt 511501 tctaattcaa actgtgataa cgattctagg aagttttcag tgggtggaat aagcttactt 511561 aaattatttg tataaatatc aatatacacc tgcaaatgac ttgcagaaat aaaagatgcc 511621 tcgtctatag attctgctgc aatcacatta atgcaagcga tcacataagg ttcttgtaaa 511681 taagaagacg gttggaaatt ttctcgataa atagagagcg cttcttccat cgaatggggt 511741 gaaaattgag cgccaaatgc atagggtaaa ccaagctttg cagcaatttc cgctgaatcc 511801 gttgaggatc ctaacacaaa aacaggcaca tgcgttccaa tacccggata agcgcgaacc 511861 tcaccctgta cactcttatc cccgacaaaa cgcaaaatat catttacttc tctttcaaag 511921 aaaaacactc cattatggtt ggaacgacga atcacatcgg ccgttttttg atccgttccg 511981 ggtgcgcgtc ctaatgccaa atctacacga tttggatata atgtttcaag tgttccaaat 512041 tgctccgcta cgattaatgg ggaatgattt ggcaacataa taccccctga acctacgcga 512101 atgtcttttg tatttgctaa tatatgttgt acaattgata cggttgctgc acttgcataa 512161 gcgtcgtgat tatgatgctc tgcaaaccaa atccgtttat agcccatatt atctacagct 512221 ttagctaatg acactgcaga atcaatccct tgtttcattg tttctccttg tcttaatgga 512281 gcaactgata aaacagatat atcaaatttt ttcataattt cacctctaaa ataatgaact 512341 tatacaagat caatggaaaa aacattttga aaaattgttt catattaaat ggtgtccatt 512401 cctctttgat ttgcatgcaa ataaatatat actttctcaa acgatcaata cataggcaaa 512461 ataaagttat ttcacaattt cactttactt ttaaagtttt aagcaaacat aaaaaaatgt 512521 tcagtgaaca aaatatgtaa aatacatctt atttttcaga aaggatacaa gaaaatgatt 512581 gatgaaatag ataaaaaaat acttgatgag ctgtctaaaa atagtcgcct tacaatgaaa 512641 aaattagggg aaaaagtaca tctcactgca ccagcaaccg catcaagagt agtaaagtta 512701 atagacaatg gcataataaa aggatgtagt atcgaagtga atcaagtgaa attaggcttc 512761 tctatacatg cttttcttaa tatttatatc gaaaaaatcc atcatcaacc ctatttagct 512821 tttatagaaa cacaagataa ctatgtaata aacaattata aagttagtgg agacggttgc 512881 tatttgcttg aatgtaaatt tccttcaaac gaggtattag atcaattttt aaatgactta 512941 aataaacatg caaactataa agtgtcgatt gttattggta aatagttaac tttataaaac 513001 ggagatgtgc ggtcatataa catgatatat atgctctaaa aaagccctag gttggatatg 513061 gaatttacca agctggggcc tttttataca ttataataac aagcgcatta ttcatcagac 513121 attaatgaag tattataatg cttttttact tccttaatag acaaataaag ctgatagttt 513181 ccatacttca ataaatcatt cagaaggtga tttaaaactt cttgtgaatg aaccgttacc 513241 ttcagaagat aacatgcatc tcccgaaaca cgatgagctt cgctaatttc attacgagta 513301 gcaataaatt tcaataaatc atcatgcata tatgcattca tgaaaaagaa gacaaaggct 513361 gtaaaagaaa accccatctt caattcatca accacaatcg aatatgcttt aatgataccg 513421 ttatcctcca tttttttgat gcgattgcct accgcttgtc ctgtcatatg aattttttca 513481 ccgatttctt tccattgtat ccgagcattt ttatttaata attggagaat ttgaaaatca 513541 attgaatcaa tttgcatagt aactcctttc acagtgaaaa agttttacaa aatagtattt 513601 catgagacca tcgaaaattc aatggaaatt atatatcctt atacagtata aaaattttaa 513661 gaggtgaaaa aatgacaaca gctttattag tgattgatat tcaaaatgat tactttccaa 513721 atgggaagat ggctttaaca aacccagaga aagcagcaca aaatgcggct aaactacttt 513781 cacactttag aaacacaggc gcacctgtct ttcatgtaca gcatatcaca gaaggtaaca 513841 tcgctcattt tttccatcca aatacagaag gtgtcgaaat tcatgagtca gtacgtccat 513901 tagagaaaga gacagtcatt gtaaaacata tgccgaatag ctttttcaat acagatttaa 513961 atggaaagct acaagaagaa ggggttaaag aattagttgt ttgcggtatg atgtcccata 514021 tgtgtattga tgcaacagtt cgttctgcag ttgaacatgg ttatgtatgc caagtggtag 514081 aagatgcttg cgcaacaaca acattgcaaa ttgaagataa aatcgttcct gctgagcatg 514141 tccattacgc atttatggcc gcattaaatg gtgtctatgc aacagtaaaa accacagagg 514201 catttttaaa ataaaagaat ttcctgcgcg aacataacgt ctttcttttc acaagaaaga 514261 tgattcaaca acttaaaaaa ggatgttcag aaaaatactt ctggacatcc tttattcatt 514321 atcttttatt gtttttcagt atcattattc ccatctgata aaagatcaag atgtcctgtt 514381 tttgatccat agtaagacca tatacaggga ttgtttttgc cataaatata gatattgatg 514441 aaggtttaca taaagcacct aattgcttga tttactttaa tgttagatcc ctcaataact 514501 ccattctctt ctaatttctc tactctagct gtagctgctg ggcatgttaa atgtactctc 514561 tcccagatct ttcattgaat tcggctatta tacataattt ctctataatt ttttatctgt 514621 ttgatctatt tgaacgttaa ttcctttcga aaataaagtc aaagagttaa aacacttttt 514681 tttatctatg tattcgaaca ctgctgatat tatacactta actctgtcga tctaagacaa 514741 ataaaaaaag aaagtgagtt gtaaatatga atattacaca aattcgaaat gcaacaattg 514801 ttgtaaaata cgcaaataaa aaatttttga tagatcctat gttagcagag aaaggtacgt 514861 acgctacttt ccctgaaacg atcagacaag atttatttaa tcctttggtg agtttgccaa 514921 catcaattga taacattctg gatggcgtag atgcggtaat tgttactcat ctacacctag 514981 atcactttga tgatgtggca aaaaacgtat tgccaaaaaa catcaaaatg tttgttcaaa 515041 atgaagcaga tgcaaaagaa gtaaaagcaa gtggtttcaa aaatgtagaa gtgctacatc 515101 aagacactgt ttttgaaggg atccaattag taaaaacaaa aggtgaacat ggcagagggg 515161 aagagttatt aaacttaatg ggtgatgttt gtggattagt attcaagcac ccaagtgaaa 515221 aagttttata tgtagctggg gatacagttt ggtatgatgc tatcgaagac gagattcata 515281 cacatcaacc agaaatcatt gtggttaatg gtggagacaa tcaaagatta gatttaggtt 515341 cactcatcat gggaaaagaa gacatctatg aagttcacaa ggctgctcct catgctaaga 515401 ttatatctgt tcatatggaa gctgttaacc attggacact atctagagaa gaattaaaaa 515461 actttagtaa agaaaaagga ttctcaagta atattttagt gccagaagat ggcgagtctt 515521 acacatttta atatgaacac cgacaaataa atagaagaag ctcataatta taaaaactaa 515581 tcatgagctt cttctaataa tgaatatttt aaattttaaa tatatcgaaa atcctaaata 515641 tacggaataa caaaaatgga atgttccaat gatgacaaaa aaacttgaaa agcaacaaag 515701 atgtgtcgtt aggaggtaga attcatggta atgacaaaaa aagatacaaa tatatcaaca 515761 cagcagcctc tttggttaca aggttatatt gattcaccag aaaaacaaaa ccaactttat 515821 aaaaaaacat taaaaatctt gattttttca caaatatttg ggggagcagg acttggagct 515881 gggataacag ttggggcgct tcttgcacaa gatatgatag gatcggaaaa tgtagcagga 515941 attccaactg ccctctttac ttttggatct gccgtagctg ccctgcttat aggagcatcc 516001 tcacaacgtt ttggtcgcag agctggactt gcaggtggtt tccttatagg cggattaggt 516061 gctataggtg tgataatcgc ggctttaatt aacagcgttg ccctattatt tgtttctctt 516121 cttatttatg gagcaggtat ggcttctaat cttcaagttc ggtatgctgg gacagacctt 516181 gcaaatgaga aacaacgggc aactgctgca agtatggcct tagtttctac tactttagga 516241 gctgtagtag gtcctaactt agttaataca atgggggaat ttgcagattc aattggtgtt 516301 cccaatttag ctggtccgtt tattatgtca ggagcagctt ttataattgc tggaattatt 516361 ctcttaattt ttcttcgtcc agatccgctg tttgtatcaa cagctattgc gaatgctgag 516421 aaaaaagacg ataaagtaca aataggagga agtctaaaaa atcctgctat agacaaaaaa 516481 ggaataatgg taggagctgt cattatgatt ttagctcaac taatcatgac agctattatg 516541 acaatgacac cggttcacat gggtcatcac ggtcatggtt taagcgaagt gggattagtt 516601 ataggactcc atattgcagc gatgtatctt ccttcaccat tgactggttt attagtagat 516661 aagtttggtc gcacaactat ggctattgct tcaggtgcca cacttcttgc cgctgggttg 516721 gtggcagcta ttgcaccggc agactcatta tcattgctaa tcctagcact agtattacta 516781 ggggtaggtt ggaactttgg tttactaacg ggaactgccc ttattataga ttcaacacat 516841 ccatctctac gtgcaaaaac acagggaaca ttcgatgttt tattagcact atcaggagca 516901 gcaggtggag ccttgtcagg aatggttgtt gcacattcta gttatacaat actatcaatt 516961 tctggagccg ttttatcatt gttactcatt ccagtagtta tttggtattt tagaaggatt 517021 caggaaaaag cataagctta tataactgtc tttgaagaac ctaagtagac attactttac 517081 cggaacctcc tttttctatt tattatagta aggagttgac atggcattag tggcatgtgt 517141 ataactacac aattatttgg gattcagaga gcatgtaatg aacggaagag ataattattt 517201 atcactttta ttattgtacg gtgttcttgt ggcattaagt tcagtcaatt ttggtctaac 517261 tgttttcttt ttgttttcat cacctctcca tattattaac aaacacgaaa aggattttaa 517321 tgaaaataaa atgattagcg tatgtatctc taattttcaa aatgaatgaa tagtcctttt 517381 taagatttac acacttattc tccaaggaaa aatgactcaa tttttcgatt ttttatgtaa 517441 atcaaaaaag aatcatgtta gagtaggtgt gctgaaaata attcaaaaaa ttattttgcg 517501 atatgattaa agtaatattg ccagagagtt tcaattggac aaaattgtaa gtgtttaata 517561 cactggggct gcaatcaaat atgcacctgg aatcaattgc taaacggggg agtttatatg 517621 aacaacaaga aaaatatctt tgatattgtt atgtacatta ttttcggtgt gttaagtctt 517681 tttctagttg caaaaactga ttatggcact ggagttttag tgtttgttgc aattttatac 517741 ctcgctgtta ttgcttataa aattaagcaa gtatttagta attcagattc ttaaggtgta 517801 acacaaggag gatttcaatt gagaaagaaa agagttatta cttgtgttat ggctgcatca 517861 ttgactttag gctcactttt acctgcaggt tacgcttctg caaaggagga ctctaagaca 517921 accccttctt acgaagaact agctctacat tacaaaatga aaagtgaaaa gatttcatcg 517981 aacgggaaat tagttgaaat tgagtatgtg agtggaaatg aaactcacaa agttcagatg 518041 aacggaaata atcatactgt aaaagtcgat ggcatagaac aaaaaggttt aaactttgag 518101 tatgatgaaa atgttgctaa aagaacaaat tatgaaaaca ataatttgaa atcaaatgaa 518161 ttcacaacac aggctgcaaa acctaaaaag ggataccatt atgtggggac tttatctggg 518221 catacaaaag cagctaaaaa tgcgttatca gttacaatgt cattagtcgg tattgtccct 518281 ggcttgggat gggggagtaa ggctgccact attttattct cttattgggc aaaagaacaa 518341 atccctgatg cgtattataa atatgattta tacgaaaaag gagcaatgac tgatagttgg 518401 tatcagtatg ctacagttca attttttgaa gataaagctc ataaaaagaa aatgggcaaa 518461 ccttggacaa gtactcctgc aaaagtagat ttacctaata gctaatttta aaatcacttt 518521 gtctttataa aggacaaagt gattttttgt tatacagaag taaaatccct cgtctgagga 518581 atcttggaaa aaacttggtt caattttgat ataacatgtt tttttcttgc taatttagtt 518641 tttctatgta tcgctacaca ttctaaataa taagatatta gccggacggt tgatgccaag 518701 ctcaaaagtt tatatggaag tcaaagcata aaaaagggtg ttacaacgtg tagtcttctt 518761 tttattttgc caacgtaaca agtgtgaaag taatgatttg taggatcagt taagaaaggt 518821 ttaagattag atattgaaaa attttatata ttttcaataa aatactggta ctataataaa 518881 tgtatacaga ttgtatggag atgtaattaa ttaaaaagga gttttttaat tgcgttggag 518941 taaatggttc aatgtttttt gtatagtagc attgggatca atatatggtt ataaattatt 519001 tactaaccaa gaagtcagta ctactcgttt aataatagct tctgtaattg tgttgtggaa 519061 tattgttgga ctttttagca aagaatcagt aaaacaagca cagcaagcaa attaaaagtc 519121 ataaagttgg gaaagaagga tgttacttat gtagtatcct tctttattat tccttgaaaa 519181 atgaaacaaa ttggagatta cagcttatat aatcaattga agtcgttgat tattttcatg 519241 aacaggagat ttaatgcttt ctgatgaaat attatcgtat gaatgttgca agaggaaacg 519301 ttactcaaag attacaggga tgtgatgaac actcctcttt atcgcactca cctgacccca 519361 aattgttggg gaagggcagg tacggaagat agagtatttt ttcttcgtaa caaatcgaaa 519421 aggttggata ataaaaaact tataatctaa ggcggtatat agttgtgaaa aaggcgttat 519481 ttcttatatt agaccagtat gcagattggg aaggtgttta cttagcatct gcattaaatc 519541 aaagagaaga ttggtcggtt cacactgttt ctttagaccc tattgtaagc tcaataggtg 519601 gttttaaaac atctgtcgat tacataatag ggttagaacc tgcaaatttt aatttgctag 519661 ttatgattgg cggggattcc tggagtaatg acaataaaaa actattacat tttgtaaaaa 519721 ctgcatttca aaaaaacatt ccaatagcag cgatatgcgg tgcagtggat tttttggcga 519781 agaatggttt gctgaataat catagccata caggtaattt tgtttactta tggaaagatt 519841 acaaacaata taaaccgatt agcagttttg tagagaaaca agcagtaaga gataaaaatt 519901 tggttactgc taatggaact gcccctattg aatttactaa tttaatttta gagatgattg 519961 attttgatac tcctgagaac atagagaaaa tgatgtatat gaatcgttat ggtttttatc 520021 atttttgtga taaatatgga aatccatttg ttgattaatt tgctggaaat gattttcccg 520081 aatagggggc tttgcgattg agttgaattt cctaataaag caaagaaaga tgatttgagg 520141 tcaagtttaa caaataatgc catcaatatt aatttgcagt tatttccgat tcctgatata 520201 ataaagaaga attatttttg ttcggtgtaa aggatagtat gaagattgac ttttcgtctt 520261 gatgatactt tgggcaagga tagtatatac tgtgtggtta cacactagga ggcaacaaaa 520321 atggaacaag gtacagttaa atggtttaat gcagaaaaag gttttggctt tatcgaacgc 520381 gaaaatggag acgatgtatt cgtacacttt tctgcaatcc aaagtgacgg attcaaatct 520441 ttagacgaag gtcaaaaagt atcgtttgac gttgagcaag gtgctcgtgg agctcaagct 520501 gctaacgttc aaaaagctta atcttcaatc gtttatacaa acaggctctt tatatagggc 520561 ctgttttttt atgtctatat catactcaat aaaaaaccct actcaacgtt cgagtaggga 520621 gatgctacaa ggtaatagaa aaagatttaa aacttcaaag gtttgtttac agtataacat 520681 actggattga caatatgcgg aatgtatata aattatttaa tgttttgttc aaatatagat 520741 aactgactct ttttttcact aacctgttcg ttcatttaag taagattaga tgaattataa 520801 aaatggtttc atctaaatgt tatcaactcg catatctctt ttatgagaag aagataaaca 520861 attattattc aatgttgcag tggatataag aaattcttaa aaataatgag gagatcgatt 520921 gtttttttct cctggaaata atcacttaga gatacctaaa acaatgaaag ccctacctct 520981 cttccatcct tacggctcct tgtccgtgcc agtgtgaatc aggatactaa aaaaagtgac 521041 tattttattg agttttttgg taaaacttca atcttcgcag aagaaatgta aataataaaa 521101 atggattaga atgtaggaat aacaaaagag gtcgttaatg ttctaaacat aagttggaga 521161 agatttgctt ttcatcataa tattccgaaa tatcttttgg gatgtatcta accaaaactt 521221 tttatttgtt tttcagtgat tcctttaatt acttccagtt cactaatcaa aaattcatat 521281 gcattatcca gcattttttt ttcgcttgca ttaagtgctt tttctttctt catacgcatt 521341 aaatcacgta caacttcagc accttcttgt atttcacctg tttttatttt gtccgtgttt 521401 attttgtacc tttgcttcca tggcagtaac ctatcggatt ctccatgctg aaaaatgtgc 521461 ataatgtgtt ttaatgcaag tatatcggta actggtcgta tattcgaact caatatttta 521521 ctcgttggaa tcataactgt catattactg attgacattc ttatgacata atactgttgt 521581 ttttcctcta agaattcttt ttcttctatg gcttcaatta tacctgctcc gtgcattgga 521641 taaacaatgt tatcgccaat ttgaaacata tcatccacct ccatatatgg tatccttctt 521701 aagattacca tatatggagg tgtaatatca aaattttaat aataacatga tcgaattttt 521761 gatgtcaata acttttttga aaaaacagat caagcaaaaa caatagggaa cgtgtcggat 521821 ttccaatcag gaaaaggtca attgatccgt gtgagcagtt tttcattggc tcaatgacat 521881 tacagaaatg atttgagtag ataagaaaga acgatattcg tgaaatgtca gctaaaaata 521941 tttaaagcac atgattaagt tctaatttct ttaccgattt gatatggata acggccgact 522001 tacttaatga tgcattttca cttatcttgc aagcagaaaa aggtttgttg ataaacattt 522061 agccaccaaa ttggcattat tatcagggaa attgacaacc ttcaaatggg tattgaggcg 522121 agaagaaaaa taaagaaagg agagattata aatgaagacc agaacataaa gaagtaaagg 522181 ggaaagaaca aggttaattg aaaagcaaac tatataaaat agtttgcttt tttttgttat 522241 gacttcactt ctttttcttt ctctttaatg actaataaaa caccgctcag aattaaaaac 522301 gaacctatcc aaaatgtccc gcctatttgt tctccaagca gaatccatcc gagtaaggtt 522361 ccaaccagag gctgaaaaaa gaaaaagagg cctccacttg aggcatttaa taattgtaag 522421 ccgtggttcc acaataaaaa tgcacaagct gttgaaacaa ttcccaaata caaaaggcca 522481 cctagaattt tagggtcaag cagtagtggc gtaaaaatcg tgctagggga gtaccattaa 522541 cagggactcc atttattaat agaataaact ttatgaattc atttttttgt atgataatgg 522601 cgtcatattc atcgcttgtt gaaatttact tatgaaataa ctggtactgt taaatccaac 522661 ttgataagac acttctgtca cattggattc agggtgttgc agtaataata agcttttttg 522721 aattctataa tccattacat aacgtaatgg cgtcttattc agcattcgtt taaaataacg 522781 gcagcattca gaacggctca gttggccagc ttttgcaatg tcctctaatg tgattttttc 522841 aacataatgg agatggatcc agtttaacat ttgtttcatt cgatgacttt ttatcatttc 522901 agattgatcg tactctaatt gaaaaccatt aacgaccagg tttttccaca ttaacgttaa 522961 ttgcatcgta atgtcaatct catagagcga tgtcttttgt tgaatcaatt gatttatttt 523021 tttaacagca tctagaatat tttttgccca ctgttgattt ccagccaaaa ataaataggg 523081 caaattggtt gaaaacatat agggctgaac atagcttgaa tacagttcct gagataaaac 523141 gaaatggggt gacacattca agcaaatata cgtacaatcc gagccttcct tttcttcggc 523201 catgtgcagg tagccgctat tgataaataa tccatcccct tcgtgaacct ctattttttc 523261 ttcatttatt tgaaagagag ctatcccttt tagtatcaaa acaaattgga tttcatcatg 523321 ccaatgaagc ggaatatagc catttatatt ttgattgatc gttgtcttgt agcaggcaac 523381 tggcaattct accgttcggt gctctgttaa ttcttttaaa ttttgatcga tcacaaaatt 523441 cttcattctg acttcacacc tcaatatatt tatatttttt cattcaattt gagtattttt 523501 tatcatgttt tgcatttatt ataacactat tattatattt attagtgagg agtcatgtat 523561 gaatacttcc aatagaagaa tgggattgtt ctatgttatc acaggggcga catgttgggg 523621 gattggaggc acagtagcca aaaaactttt tcaagaatat caaattgatg tcaattggct 523681 tgtaacgaca cgcttgctta cggctggaat gttactttta atgctgcaac tgttcagaaa 523741 ggatcgttcc caggttattg aggtgtggaa acacaaagcg tcggctggcc agcttctaat 523801 ttttggccta ttgggaatgc tagctgtgca gtacacatat atggcatcca ttcaacatgg 523861 gaatgctgcc gttgctacgt tattgcaata tttatcccca gtaatcgtca ttatctacac 523921 gctgttgcga aaacaaacgg ttcttaccaa acaagatatc ataactgttg tacttgcttt 523981 agtgggttgc ttttttttgt taacaaatgg ttcaatgtct caactttcag tgccggcagc 524041 tgcagtagta tggggagttt tatcaggatt cgcggcagct ttttatactt tgtatgccgt 524101 tggtttatta aataaatttg attctcttgt cgttgtaggt tgggctatga ttattggcgg 524161 ttttgcattg ggttttatcc atccgccatg gcaactggat tttcaacgat taactgctga 524221 ggcgtatgca tatatcttat tcgtgatatt atttggaaca atgattgcgt tctggttctt 524281 cataaaaagc ttggaaagcc tctctccaaa agaaacaagc ctactaggca gtctagagcc 524341 tctatcagct gttgtaacaa ctgtcgtttg gttaaaagcg ccatttggtt cttttcaatg 524401 gattggtgct atttgtatta tagggataac tttaatattg gctttacata aagagccttc 524461 tatggagagt gaaaaatcga tattaaagat taggaatcat gcaaatcggg atatataggg 524521 gctttttttg cttacatgac cggtccggca atgaaaaaca ctggtggagt ttgagccctc 524581 tcggcagtat caaaaatacc aagggttttg acgccctagg tattttttct tcaagaacct 524641 tcaatttttc ttctctgatt gaaaaacgta ttactttttt gtgattggta tccaaatttc 524701 acttttaaaa gatggtgatg ttacatcctt atgctcgttc cacaatattt ctggaccttc 524761 tatttgttcg taatttgacg atggaaacca ttcggaataa atgcgtcccc atacttcttg 524821 cagtgtatcc ggaaatggcc cgattgattc gaatacagcc catgttgagg caggaacttc 524881 aagccgtgag aagttatctg gacaccgttt cgttgtggct gcgccaatat agtgatcgag 524941 ctctccgttt tcctctgtcc gaccttcaga aaaattcgtg gatgcactaa tgaggcctga 525001 tggtgctaca ttagatagct cttttagttt atttattgct ttttcatcta aactttccca 525061 catagatgca atttccggat taattccttt gaaaataata ggaactcttt ttttaatgcc 525121 aacgatgcga aatgcctctt tttcttcaat acggtagttc atttcatttc ctcctttaat 525181 tgttagctgg aaggtcattc gtggataagc tttaagggaa tggccattaa atctggcttt 525241 tgatgggttt atgccatgta aattttggaa tgcccgtgca aaagaatctg gtgagttata 525301 accgtacttt attgcaatat caatcacttt tacattgctg tctttcagtt caaaagctgc 525361 aagagtaaga cgtctgcgac gaatatattc cgataatgaa atacctgcaa ggaaggaaaa 525421 catcctttta aaatgatatt cagagcagaa agcaagcttt gctgcctctt gaaaatcaat 525481 atcattagtg aggttttctt caatatactt taacgcccta ttcatacttt taagcaaatc 525541 catttatttg gcctccttta accaaagaat aacaggagtg aaatgtattt atccgacatt 525601 ctgtgcacag ttttgcagga tgacttatat gaaataaagt aagtgattca cttgtatttg 525661 tacaggtttt attgaagcat gctgttcata aaaaggcatc aataaaagaa agttataatt 525721 gtcttataaa cggcacattc atataattga gtgaaaaagg atgcgtatca tgcctatcaa 525781 ttcttttgaa aattatccga tgagctggaa gccatcgatt gataaagctg aaaagcctat 525841 ttataaagca cttgcagggc aattggaaca ggatatttta aacggagttt tattacctgg 525901 aacaaaactt cctccacagc gagaattggc cgattatcta gatttaaatg tgagtacgat 525961 ttcaaaagca tttaaagtgt gtgagttaaa agggctgctg agtgcgactg tagggagcgg 526021 cacatttgta tcgtatgatg cgttgtcgaa tgcgtattta cttgaggata ctaagccgac 526081 acatttaatt gaaatgggag caatacttcc agatcacgct tcatatgagc ccttgttata 526141 ccaactgaaa aacatggttc atgaggagga ttatgaaaaa tggtttagct atggccgggc 526201 aggtgaaagc ctttggcaaa aagatgcagc tgtaaagctc atccaaagag gcggatttga 526261 aacatccgtt gatcacattt tatttgcaaa tggagggcaa aatgcgattg cagcgacatt 526321 ggcgagtctt tgtaagcctg gagatcgcat cggagttgac catcatacgt accctggatt 526381 aaaaactgtt gcatcattgc ttagtgtgca aatcgtaccg ataaaatcag aaaacgatga 526441 aatgagtccg gagtcacttg aatatgcgtg taaaaacgaa aatattaaag gtttgtattt 526501 aatcccggat tatcataatc cgacgacttc ctttatgtct gttgagaatc gaagaatggt 526561 tgcagacatt gtaaagaaat ataatctgtt tgttattgag gatgcatcgt accatcttct 526621 caacaaaaat ccgcttccgg cactcgcctc attcgcaccg caacaggtta ttcatattgc 526681 aagtttatca aaatcgttag cgccaggcct gcgtttggct tatgtagcag tgccgagaca 526741 atataaggag ccaatatcaa aggcgcttta taatttaaat ataactgttt ccccgctatt 526801 agctgaactt actgctcgca cgattgtatc aaatcaattt gaagtcttaa ttgagagtca 526861 tcgtgaacaa accattcgca gaaatcaact cgtaaaccga tatgttgcgg gatatacatg 526921 tttaggtgtt gaaacaggca tttttcgttg gttgttgtta ccgggtaaaa tgtctggtgc 526981 cgaatttgaa gaattggctg ctcgacttgg cgtgcaagtg tatgcggctg aacgctttgt 527041 agtgggaaat agttgtcctg aaagggctgt aagggtttct gtctgtgcac caaaaacact 527101 tgaagagctt gaacaaggat taatgatcct gagacgtttg ctagacgatc ttacctaata 527161 ttgtttgcca tacaattatg acattgtatg gcttttttgt gcgtgttatg atgatccaca 527221 tctagaggga ggtttataca aaattggctt ttagaaagga aggtcagatg atgttagaca 527281 aggacagcgt aaaagcaata gatgttcaaa ctgcttcatt acagagctac atcagttcac 527341 cagaaaaaca aaaatcgtta tacaagcgta cactattcgt tgtgagtatc tcacaaattt 527401 ttggcggtgc ggggctggcg gcaggagtga ctgtcggtgc gcttattgca cagcaaatgc 527461 ttggcactga tgcgtttgct ggtttgcctt ctgctttatt tactttaggg tcagcaggat 527521 ctgcattaat tgttggaaga ctttctcaac gttatggccg tcgaacaggt ctttcagctg 527581 gctttatgat tggcggactt ggagcaatag gcgttattat ggcagcaatc ataaatagta 527641 ttttcttgtt atttatttcg ttgcttattt acggtgcagg tacagccact aatttacagg 527701 cccgttatgc aggtacagac ttagcaaatc ataagcagcg agcgactgct gttagtataa 527761 ccatggtttt tactacattt ggcgcagtgg caggtccaag cttagtgaat gtgatggggg 527821 atttcgctct ttctattggt gttccatcac ttgctggccc tttcatttta gccgcagcag 527881 catatatgtt agcaggtgtg gtccttttca ttatgcttcg tccagatcca ttagttatag 527941 caagaacaat agaagcggca aatgaagagc ctggtgataa aggacatttg gcggcaactg 528001 agcatacaga aaacaaaaaa gggataatcg ttggggcaac ggttatggtt cttacccaaa 528061 tagtaatggt agctattatg acaatgacac cggttcatat gagacatcat gggcatgact 528121 tgggtgcagt cggtcttgtt attggttttc atataggtgc tatgtatctc ccttcacttg 528181 ttacaggtgt tcttgtagat aggttgggac gtaccgcaat ggctatttcc tctggaacaa 528241 cgttgctttt ggcaggtgta atagcagcat ttgctccggg agaatctatg attcttctcg 528301 tcattgctct ttctttactg ggattagggt ggaattttgg tttgataagc gggactgccc 528361 ttattgtaga ttcaactgat actgccacac gagctaaaac gcaggggaca gtggatgttc 528421 tgattgcgtt gtcaggagct gctggcggag cattatctgg aatgattgtg gcaggttcaa 528481 gttacctcgc attatcactt attggaggga ttttgtcctt attactcatt ccggtggtgg 528541 tatggtctag gggccgctaa agggtaggat tgtttaattt acattaattt gttatattgt 528601 tagataaagt atattgcagc atctaatatt ctaacgaact atagttgctc cattaaatct 528661 attataaaga tttgaccagg attccttata gctgtgtcac tcactgcata ttctttaatt 528721 gaatcacata aaatggttat cggatttgaa aaaggcagga ttactcgctt taggtaaagg 528781 agtcataacg ttgttaaaaa ggttttctct tgttattgtt acactaatga tgtctatcgt 528841 tgttgtttta gcggctgcta aagagtcgcc tggagatcat gtcatctcat ttgatgaacc 528901 tattatcttg atgatctcaa ttggaatcgt tgtattttta ttgatccctc cattagtcat 528961 gtcctttttt ggcaatttgg ttgtaagaat aatatctggt gtataccaat gttttatcgt 529021 tttcactttt ctggggctca ttccaattgg atttcttatt cccaatggct ttttgacaat 529081 tctagtttct attgcaggaa ctttagtcag tatagctagt gttgccgtaa ccttatgcat 529141 tggcaagaat aaaaaagata tataatcatc gaattgttat tttttcagat tgtcagtgaa 529201 ataattatac aaaaagagaa ggcttgtggg ccttcttttt ttgttgttgc atcatcccca 529261 ctttgagctt aatctattga ataataagag aaggaaccta tagaagaata aaataaatac 529321 cgagatgtca aaaataaaac tggacttcat tattgtgaat tcacgtaaat gtaaaaagat 529381 tggaaagagg ggaattcctt catgacaaat agcagaacaa atccgaaggt tgatgaattt 529441 ttaagtaaag cgaaaaagtg gaaggaagaa tttgagaagt tgagaaccat cattcttgac 529501 tgtgagctga ctgaagattt taagtggatg catccttgtt acacatatca taataaaaat 529561 attgttttaa tacatgggtt taaagaatat tgcgcgcttc tgttccacaa aggcgtctta 529621 ttacaggata cagatggaat tctcattcaa caaacggaga atgtacaggc ggcgcgccag 529681 attcggttta caaatgttca ggaaataaat gagctagaaa acattttgaa agcctatatt 529741 cacgaagcca ttgaagttga aaaagccggt ttgaaagtgg atgttaacaa aaatattgaa 529801 ttgaacattc ctgaagaact tcaaaataaa ttcgatgaaa tccctgcatt gaaaattgct 529861 tttgaagctt tgaccccggg acggcaaaga gcgtacactc tttatttttc tcaagccaaa 529921 caatccaaaa cccgagaatc gagagtcgaa aaatatgtgc aaaaaattct cgatggaaag 529981 ggattaaagg attaggcacg ccaaggttca ggctaaagga atagcatcat agcgtaataa 530041 gatcatttct atagaagaaa aacaagcata gtaagatgct tgttttttct taggacaaca 530101 ttcacttact gctgaaatgc ttctaacatt gtatgccact agacagcgtt ataaaatatt 530161 aatgcaacac ctagaaatct atccaatgaa atagctcaat ggtatggctc attacattta 530221 gaatgcctag gagaactaat agaaccggaa gatttttagc aagttactac actccaaact 530281 ttgtttttgt attaatatac cttattaacc attgttttta gtcaggtgca gacaaacgaa 530341 tactgattaa tgaatcatca tgatatcaat gagccgcttg attttttcat cgtcgcctgt 530401 atcaacgtac actgtttttc tgttttttat gatactctca gtcacttccc gcatgacgcc 530461 tttttctata tcatcagcgg aatcccagcg taaaggcaca ttatatacat gaattgtgcc 530521 atccccattg ccatgataag tgactgatcc atccactaaa cgagaacctg ccaactgggt 530581 cacattttct ggatagctgg cacttgtatc atcattagga ttaattggct cgccagccgc 530641 aatatgtcga acatttaatt catctatctc ttgattaggt ccaagttgaa gccaaactct 530701 ggcatattca attttttccg aagagtatgc tgccaataca ttgtcttctt tgcttttctc 530761 ttctgctgaa gaggtatcat ttgcagcttt tgttgcggat tcttctgatt ctgttattgg 530821 ctccgcttca tccttgcgta ttttggtgct ctcttcaggc tcagtgtgtt tttcgtcagt 530881 ttgcacagca gaagcttgat ttgaaggttg ttgtgcttct ccatccttac tgtccgtaca 530941 tccagcaagc aaaatcataa gcagcagggc agtattgcaa taacatatct ttctgcgttt 531001 cttcattttt tcattcctct ctattaattc aggtcagctt catatataag tttatgtatc 531061 taaatattac catggaatag ataggatgat attgaaaact gtttaagaag aggaaacgat 531121 cttgaatagc atcgcgaaaa cctaagaatc ttaagaagtt ttgccccttt ttcttcaggt 531181 attgaatgta aagtgggata taaatgcaaa caaaaacgaa atgccttatc cacctcgtgt 531241 catggcagaa aaagtggggg atttattaga gcggatttga taatggcggc aggtaaatgg 531301 gtgttgactt atatgtctaa gcgggagact caagtctgct cgatcgcata caaaatacca 531361 agggccagca acccttggta tttttatacc ttcatgcatt tttgaagttt atgcttaaag 531421 gtctgcctta ctttgcaaat cgccgagctg ctgcaacgca catgataacg gcgatattca 531481 ctgctacgag tgcccagccc actttctcgt gcagaatcac tgaggcaagc agcagtccaa 531541 aaaaaggctg gagaagctgg agctgcccaa ccgctgcaat tcccccttgg gcaagacctc 531601 gataccagaa cacgaagcca atcagcatgc tgaataagga tacatatgca agactgagca 531661 gtgcgggaac gccgatcgcc gaccatgagt ccggcgtaaa aaagaacgac aatggcagca 531721 taagaggaag cgacagaacg agtgcccatg agatcacctg ccaattcccc agacgccgtg 531781 aaagtttggc cccttctgca taaccaagac cgcatacgac aatagaagcc agcatgtacg 531841 cgtcgccaag cggggatgaa cctcccccct gaatgagggc gaaacctgct actaacaagc 531901 tgccggcagc tgagaaaatc cagaagacgg ggcgagggcg ttcacccccg cgcagtacgc 531961 cgaagactgc cgttgcgagt ggaagaagtc caatgaagac aatggcgtgt gcggatgtga 532021 catgctgaag cgctaaagct gtcagcaacg ggaaaccaat cactacgccg aacgctacca 532081 ctaacaatga aatgagatct cttttggcag gatgctgctg ccggaagatg agaaggagac 532141 ctcccgccag tacaccagct atcgcagcac ggcaaactgt gagaaataac ggatcgaagt 532201 ctgacacagc caaacgggtc gcaggcagcg agccgctgaa aatgagtacg cctataaaac 532261 catttatcca gccatttgtt gttttgttca ttataatcac tccacatatc tttcttgttc 532321 attgtctgta ttttcttaac aaaaccagca gctaaggatt acaatgacta taaactggaa 532381 ttggcctttt ataaacagcc agttttcata aaaaaatgca taccagttag gagaacaacg 532441 cgcaaatgga tatcacgcct tttttgaata gaactctgga tattccgctt tatcagcagc 532501 tttatcggta ttttaaagaa aatatgcatc ggggccgtat tcaaaaagga atgaagcttc 532561 cttcaaaaag actcctggcg aatcagcttt ccatcagcca aacgactgta gaacgtgcct 532621 atgaacagct cgctgctgaa ggttatattg tgagcaagcc aagaagcggg tggtttgctg 532681 attatcatga ttctgatttt gcttatgata gaatgccaag cacaacaccc attcaacaag 532741 aagcagaaga aaataaacaa tggattgatt ttcattatgg gaatgtagat tcttcttact 532801 tccctttttc cgcatggcga aaaagcatgg tcaatagctt agaccaatat ggacacgagc 532861 tttatcggcc gggacatgtt ttaggagagt ttgagctgag aacactcatt gcagagtacc 532921 tgtatcaatc tcggggggtt cattgcggcc ctgaacaagt gattataggt gccgggaacc 532981 ctattctgct gcaaatcttg tgccaagttt ttgagccgaa tatttctata gggtatgagg 533041 atcctggtta tccaagagca cgcaagattt ttgaagccaa ccgcatgaat attgttccta 533101 taccagtcga tgatgaggga atctgtatac agaagatcaa agaacagcag ccaaaccttg 533161 tatatgtcac accttcccat caatttacgc tgggaaccat aatgacaata aacagaagaa 533221 ttcagctgct caaatgggcg gccgaaaatc aatcctttat catagaggat gattatgacg 533281 gggaatttag gtacacagga cagccggttc cttctctgca agggcttgat cagcataacc 533341 gtgtcattta tatgggcact ttttctaagt ctcttttgcc ctcgctgcgt atcagctata 533401 tgattcttcc ttcgcctctt ttaaaaaagg gtcatgaaat cacgtcctta tataagcaga 533461 cagtgtcctg ccacagtcag ctaaccctag ctgaatttat aaaaaatgga gagtggcaaa 533521 aacacatcaa cagaatgaga aaactttacc gcaaaaaaag agccattgta ttagaggcag 533581 tgcaaaggga attaggagag catgtcagaa tccgcggaga aaactctggg cttcgtatct 533641 tacttgacgt ttatttgcca tttggtgaaa aagagttaat tgagaaggcg aaaaaacatg 533701 gagtaaaaat ttatcctgtt tctctttctt atcaacatca tcctcctaca aaaacggtct 533761 cgctcgggtt tgcaggggtt tctgaatccg acataagaga aggcataaaa aaactgaagg 533821 ctgcctggaa gatatgaggg agctttcagt ttagcaaaac ggccaagtga cgactaagtg 533881 ttgagagctg ttcaatattt tttaagtata tgatgagtgc ctgcagtcca ggccacgata 533941 cgtctgttta gcgaaaaaca gaatttttta tttgctcctc acagtgctaa aataaacaaa 534001 atagacaatt gaaaaaatag aggtgtaaga atgaagttag atgagtttac aattggccag 534061 gtcttcaaaa cgaaatcatt aaaagtatca aaagatgata ttatgcggtt tgcgggtgaa 534121 tttgaccctc agtatatgca tgtagatgaa gaaaaagcga gtaaaggcag atttaatgga 534181 attatcgctt ccggcataca aacactggcc atatctttta aactttggat tgaagaaggt 534241 ttctatggag acgatattat agccggaaca gagatgaatc atatgacatt cataaaaccc 534301 gtatatccgg atgatgaatt gtttacaatt gttgaggttc ttgataagca gccaaagaga 534361 aatgaattgg gaatactcac agtattgcta tctacttata atcaaaaaga agtaaaagtg 534421 tttgaaggtg agttatctgt attgatcaaa cgataactca gaaagcccgc ttttcgcggg 534481 ctcgattgaa gcagatgggt gaaagatgtt agcgggtttc ctttgaaaaa taagaggtta 534541 aaacatcata aacaataggc aaagaagtaa atccctcatc ttctagaaaa tgacctccgt 534601 gctgaacttc atataacgca gcatcaattt gttgtgccag atccttgctg aatgaaaaag 534661 gcacaatttg gtcgtcctta gaagcaatga cagcacggtg cttcgcggac tcgatgattt 534721 tttgatgatc aaacgatccc tgtgtaaatt catctaacat ctgtaaagtg ggcaatgatt 534781 tggcaaagcc ggaaacaagt atgattccgc caagctgttt tcgtaattga agatgttcca 534841 aaaatctcaa aatggcgggg caacctaagc tgtgcgcaac caaatacgta ttttcatgta 534901 aagtgtgctg atataaagag agtgtatcca gccaatcctc aagtcttggc tggagcggat 534961 taggcatgtt taaaatgtct gcttggaccc catctgcgag cagacgtttt ttcagccaag 535021 ggaaccaatg atttgttgag gaggctctgt agccatgaat gatatagact tgttttgtca 535081 ttatttcctc ctaagaaata ttttcattca gtataaaatt cctctcattg ggaaacaagt 535141 acgcactttt ttgtaagtag ctttacatat gaggccctcc ttgtgccatt ccccacttac 535201 acatctcatc tatgagggga tacaaagatc gccctctgtc agataacgaa tactctactt 535261 tcagtggggt gtgagaaacc tcagaccgat gaataaggcc gtcagtttgc aattccttaa 535321 gctgtgcgct taacatttta tgggtgatga agggcatagc ccttttcagc tcgccgtatc 535381 tcatcgtttt ttcacaccct aactcataga gaattctcat tttccatttg ccccctataa 535441 gagataaggt gtattcaaat ggggcttgtt tactgcggca caggctattc attgtaatca 535501 aacctccttt tttaagtatc atatcagaat aaattaggat tttcggtgtt gaagtttgag 535561 ggcgattcac gatctgaagt gaaaggggcc gcttgctcaa caggcggcac ggtacatgaa 535621 tgttctaagt caaagagggt taccttactg ttagttactt tatttaaaaa aacgcatgtt 535681 tttagctgaa aatatctatt atggtatatt taaatataaa gaaatatttg agaaatgagg 535741 aatggtatga atacacccaa aaaacataag aaatttaaag cgaaaatgat tctccaaatc 535801 atcatggtta tcattggagg aatcatagcg gcatatggac tagaaacagt gctcattcca 535861 aacagtgtat ctgatggagg ggtgacgggt cttagcatcg ttggttcaca gctattcaac 535921 ttgccgctgg ggattttgat tgctgtgatc aacattccat ttgtctggtt aggatataag 535981 caaattggga aaagctttgc attattatca attatcggaa tcgtatcgct tgccgcgggg 536041 acaagctttt tccaccacac acccgctatc atagaaggag ataccctgtt aattaccgtt 536101 gtcggcggga ttatccttgg attcggaatg gggctggcgc tgcgtaatgg cggcgcatta 536161 gatggaattg acatgcttgc tgtgctgcta tcccgaaaac tgccattcgg aacgagcgat 536221 ctcattctat tcttaaacct atttgtgttt atttttgttt ccacagtatt tggcttacaa 536281 ggggcattgc tttcagtcat tgcttactac attgcatcca aagtgattca tgttgtggag 536341 gaaggcttaa gcggctctaa aacctttcaa attattacaa cccaacctga attaatggta 536401 gagacaatac gtgatcaatt aggccgaagc gccacatata aagaagctta cgggggtttt 536461 tcccacgaga aatttaaaga aatcacatgt gtcatcaacc gtttagaaga aaccaaacta 536521 aaggaaatta ttaatgatat tgataaaact gcctttgtta ccgtgtatga tgtagctgaa 536581 gtgaagggca gcaattttag aaatcttaat catcactaaa aaatagaatg acctttttaa 536641 ccgtaactga catgccgcgg gtaatttaat caaaaacact tttttgaggc ttgtgggtga 536701 ataaccggtg aaggtctgaa tcacagaaat accaagggcg tcaaaaccct tggtattttt 536761 tctggttatt agattttatc ttcagcttta cgtgctgctt cgagcttatc aatcctgtct 536821 ttatattttt ctccccagtc cttcatgtgc aggataacag gttctaatgt tcttccaaac 536881 tcagttaaag agtattcgac ttttggaggg acctgtttat aaacctcgcg gtgaatcacg 536941 ccatcccgtt ccaattctct taattgtagc gtgagcatac gctgggtaat ttttgggtat 537001 agttttcgaa actcattaaa cctcttttta ccgtcaatga gatgataaag aagaatgcct 537061 ttccacttac ctccgatgat atctaatgtt gtctccaccg gacatccttc aaagtcatca 537121 gaagaataat caatgccgag tttacgattt ctcaagctgt tcactcctaa tagtatactt 537181 tttgatacta tatacattca atgtgcgtac tttttatatt ttaatataca tcatataatg 537241 atgtcacatc taaggaatga aaggaatgga tcatatgaaa acactcgtac tcgttgtaca 537301 tccgaatata gaatcctctc gtatcaataa aaagtggaaa gaagccgttt taagtgaacc 537361 agatgtaact gtccatgatc tttatgaaaa atatcgcgat caaccaattg atgtggaatt 537421 tgaacaacag cagctcctgg cccatgaccg tatcgttttt cagtttccat tatactggta 537481 cagcagccca ccgcttttaa aacagtggtt tgatgaagtg tttacgtttg gctgggctca 537541 tggtcccggc ggaaataaat tgaaggggaa agagtgggta actgccatgt ccatcggttc 537601 acctgaacac tcttatcaag ccggcggata taacttgttt tcgataagcg agctgacaaa 537661 accgttccaa gcatctgccc atttagtagg catgacctat ctgccttcct ttgccgaata 537721 tcgcgccaat acaatcagtg accaagaaat tgccgaaagt gcgaatcggt atgtaaagca 537781 tattacaaat atagaattaa acccgaaggt tcgcctgcaa aggtatttga aacagctgga 537841 gagtgtcgat ttaacataaa gattgatttt tgaaaatcct gtactcacca agcaggattt 537901 tttcttgttc agcagaggga ttttaacata tagcaaaaaa agaagaagcc accaaaaata 537961 agctatttgc ttggtcctga ctgcttattt ttggtgaaat acttatttct ctgtgatgaa 538021 ataaagcaaa gcgatgaccg gaaaagcgat tccaatccat aatgctgtac tccatccgcc 538081 tgaggcatat gcccatcctc caattgatga ccctatcgca ccgcctagaa agaagatcgc 538141 catgaataat ccgtttaatc gactgcgaat ttcaggcgcc aacgaaaaaa tagcacgttg 538201 actgagcaca aggtttgcag atacacccat atctaacaga atagcagcgg ccactagaac 538261 tgttataccg acgggggagc tgctctgaat catgagcggc agtaataaag agacaacgac 538321 aacaccgaga gcgattccag tggcaagcct ggttaagcct cgatcagcca ggcggccgcc 538381 tattggtgca gtgactgcac ccgcaatgcc caccaatgcg tagagtgcta ttgccttctg 538441 agaaaaatga aaatcaggac cggacaataa taaaggaaca gttgtccaga acaagctgaa 538501 agctccaaat acaaacgcat gatagatggc acggcggcgt aagactggag tcgtgcgcag 538561 cagcttccac attgaaccga gtaaggcagt atagtttgta tttgctgttg gttttctggc 538621 aggaagcact tttgataata cgatggccag gataacactt accacggcgg acaaagcgaa 538681 tattgcattc cacccccaga tatcagcgac tagactagat atcggacggg aaagcataat 538741 accgagtaat aagccgctca tgacattgcc aacaacccgg ccgcgtgcag cgtctgatgc 538801 aaggtatgat gcaaatggaa caagcacttg ggctgcgatt gatcccaatc cgacgaaaaa 538861 cgcagctgct aaaaacagtg ttccatgctt cacaaatgct gttagtgtca aagccgctgc 538921 gcttagaagg agcgatacaa caataagttt tttgttttcg ataatatctc ctaaagggac 538981 aaggaatagt aagccggcaa cgtatccgat ttgggtgagt gtgacaatca atccagcacc 539041 gcttggagaa agtccaattg ccttactaat taatccgacc aagggttgtg catagtaaag 539101 attagcaaca atgataccgc atgcagttgc gagaagaagg gttaaactgg gtgaaatcct 539161 ctgacctgct tgtttgtttc cattagccat atgaatgaac tcctttttaa gtggtttttt 539221 gagtgtaatc atgacttctc acaagtgatt ttataaactg aacgttcagt ttcgtcgatt 539281 aataaaaata atatactaaa cgttcagttt tgtaaatgga tttctgtttt ctttttttat 539341 tcaatttaag tatactgaac gtatagttta tattgcggga aggaatgatt tatgtgcaga 539401 gtaaacgagg gcggccgcgt gatgaaggaa cgcataaggc gattctctct gcagcctatg 539461 acctattgct ggaaaaaggc ttcgatgcgg tgacagtcga taaaattgcc gagcgtgcga 539521 aagtgagtaa agcaacgatt tataaatggt ggtctaacaa ggctgccgtt atcatggaca 539581 gctttctttc gaccgcgacg gacaggctgc ctgtgcctga tacagggtcg tcagtacaag 539641 atatagtaac ccacgccacg aatttagcta ggtttttgac aagccgggaa ggaaccgtta 539701 ttaaggaatt aataggtgca gggcagttgg atgaaaaatt ggcagaagaa tatcgcacgc 539761 gatttttcca gcctcgccgc ctccaagcga aaggccttct agaaaaggga attcagaaag 539821 gtgaattgag agagaatctt gatattgaag taagcataga tctcatttac ggaccaattt 539881 tctatcgtct gcttataaca ggggatgagg tgaatgattc ctatgtgcgt gatttggtga 539941 tgaatgcgtt taagggagtt caagctacct ctgctacaga gagtatgtag ctgataagaa 540001 ctgcaaaagc tgcggattat atgacaaatt ggttccatcg tacagtgaaa tataagattt 540061 ttgttgctga gcggaatcat cgagggaaaa gttctcttat cggatgtcga aaaagaagtc 540121 attcaatcgt gaatacataa catcatatta ttacattcct tttcatcgat tggaacaagg 540181 gttctatact tcaatggaat accgcaaagt tggagtattt aaacaacagg ggaaaatcga 540241 tggccattat gtaggtgtca tggcaatgga aaaaatactt gcaatgtaaa caggcctcta 540301 aagagacctg ttttttaata tccagatgat tgtctagttt cagcttgggc tctatgacca 540361 ctcccataac tgaaatagtc taatatttat accagaaggg attgtttata taaataaaag 540421 tttatataat gacgggggcg ctaaggaaac gcggggagcg actcaggttt tcgtttcaaa 540481 gttttgatcc ttaagatata cggagcgcta catatggaaa cgtaaagggg aatgtataat 540541 catttggcgt gtatataacg atttgcttat atattgattt gggaaggagg agctcatatg 540601 acgattgatg ttgcggcgat gactcgttgt ttgaaaacac ttagtgatca aactaggctt 540661 atcatgatga gattatttct tgaacaagaa tattgtgtct gtcaattggt tgatatgttc 540721 gaaatgagcc agcccgccat aagccagcat ttgcggaaat taaaaaacgc aggttttgtg 540781 aatgaggaca gaagaggcca atggcgttat tattcaataa atggttcctg tcctgagttt 540841 gatacattgc aattgatctt acatcaaatt gatcaagagg atgaattgtt aaaccatatc 540901 aaacaaaaga aaactcaagc gtgttgccag taaggaggca ttagattgac atcaatgatt 540961 ttggcagtat tcatcttttt attaactcta gtattggtca tatggcagcc gaaaaattta 541021 tctatagggt ggtcagcctg tggaggcgca gttttagctc taatagcagg tgttgtcaat 541081 tttcatgatg tgttaactgt gacagggatt gtttggaatg cgaccttggc ttttgtggcc 541141 atcatactga tatcgttaat tcttgataat atcggtttct ttgaatgggc agcgcttcat 541201 atggctaagg ctgcaaaagg atacggtgtg cggatgttcg tttatgtatc tctattagga 541261 gctatcgtcg ccgcgttatt tgcaaatgac ggtgcagctc ttatattgac accaatcgta 541321 ttagcgatgg tcagagcatt acattttaat gaaaaattag tttttccttt tatcattgcc 541381 agcggattta ttgcggatac cacttcgctt ccttttgtag taagcaattt ggtcaacatt 541441 gtttcagcgg actattttca tattacgttt attgattatg catccagaat ggttgtcccg 541501 tacctgtttt cgctgctggc gagcatcatt gtactttacc ttttctttag aaaaagcata 541561 ccaaaacgct atgatctgac tgaggttaaa aaacctgttg aagcaattaa agatcaaaac 541621 atgttcagac tgtcatggta tatcttaggg ctgctgttaa ttggatattt tgcaagtgaa 541681 tttttttcta tccctgtatc agtggtagcg ggcagcattg caatcatttt cttaatcgct 541741 gcgcaaaaga gtccggccgt ccatacaaag aaagtggtga aagaggcgcc atgggctatc 541801 gtattctttt caattggcat gtacgttgtt gtgtatggtg tccgaaatgc cggattaacg 541861 gatgtccttt cagatgtgat tcaagccgca gctgatcaag gattgtttgc tgggacaatt 541921 ggaatgggct ttattgcggc gattctttct tccattatga ataacttgcc gactgttatg 541981 attgacgcat tggccattgc cggtacagat acacatggga tgatgagaga agcgcttatt 542041 tatgcaaatg tgatcggttc agatttaggg cctaaaataa caccgattgg ttccttagcg 542101 acattattat ggcttcatgt tctttcgcac aaaggtatga agatttcctg gggcacgtat 542161 tttaaaacag gaattatcct cacgataccc actttattga tcacacttgt cggcctgtat 542221 atttggctgc tgataatcca ttcttgtttc taaaaggaca aggtcactat atcaaggaaa 542281 acaatgcact ggtaactctt gccgcagcca aatggctgaa gggtggggga gaaaatacct 542341 tggggctaag tggaatgtgt acagcgcagg aatcgaagct caaggatgac atcgagtgct 542401 gtcaaagcaa tgaaagaagc agggattgat atttcaaatc aaacatcgga gaaatttgat 542461 gatccggcaa aagcacacgg aacagaagaa gtgtttccaa agggtccgtg atgaaattgg 542521 tgaccgttta aaacagtttg ctgtaactgg ggaataaaga atcgatatat tcagcgtttt 542581 cttgggttat ataatacaat gtgttgttca acaggtgtct gcgagctgag tgcagacacc 542641 tgtttttgtt tttatttgtc tgagattcgt aacagggaag ttatttagct ggtgacagag 542701 gaaaattgat ttgtgaacag aatcatgaag gagacggtgt tttaaaggag ttgtctgttt 542761 tgcaggaatt aacaaaaaaa aaatacagta gcttaaaaac aatgtttgat gacaaatatt 542821 gtcccacatt tgtctattca atattagacc aaaccattcc gggagctgtt tatgcagatg 542881 atcaaacctt tcctaaatcg ttttttatag gaactgaatc aggcatttat tttattgcgg 542941 gagaccaagg gaatcgggat tttcatgatt tcattgcagg atattatgaa gaacaagtga 543001 aatcatcaaa acgatttacc ttgttttctt ccagtgatac atgggatagc gtactgaaac 543061 ccatactgaa agatgactta aaccaaatga gaagagctgc attttcttat caaccaaaat 543121 ctttcaaaaa gactttgcaa ctgccaaagg ggcttgtatt gaaaagaatt gacgaagaca 543181 tcatttcaca tagcacagcg tttaacagcg cgtattatga ggagtattgg aattctgtct 543241 cacagtttgc ttcaaaaggt tttggatttg ccgtattaca tggcaatcac gtagtaagtg 543301 agtgtacctc tatattttta gggcataatc gagcggaaat ggatatctat acacttgaag 543361 aatatagagg actggggtta gcttattgcg tagcaaatag gtttatagcg ttttgtatgg 543421 aaaatgggat tgttcctagc tgggattgtg atatttgcaa caattcgtcc attgcattag 543481 cagctaaact agggtttaag acggtaacgg aatacactat ttactactct ggctaacctt 543541 aatgaaagaa ccttaaaagg agataccaac cgatgttggt atcttttttg ttttagagtt 543601 tttttaccct tttagcagaa aaatgggtga tgaaaatctt attcatttta tttactttta 543661 ggtaggtaaa acataccccg ccaactgtaa ccactccgcc tagcagagag agcagtgtgg 543721 gtatctcgcc gatccagagc caagatatga tcaaggctaa agccggtgta acataaagtg 543781 aaagggttgc ttctgaagca ccgacgaatg aagtgacata tgctagtgcg aagtaaggaa 543841 taaccgtcgg caataatcct aagtaaacga tagacaaagt tgcgcttatt gaagcgttca 543901 tcatctcttc gcctaagcct ggcagaaaca caagcatagg tattgttccg ccccaaatgg 543961 tgaatgtaac gaatggaata aaaccatatt tttttatata gcgggcttga aaaacgaaat 544021 aaatactctc cgaaaatgct gccagcagga tgaccaagat accgctcatt gaatatgtaa 544081 agtctcccgc cccaaatgca atcaataata cacccaataa actgatcata gagccaagcc 544141 atttcgtaaa tccaaaatgc tctttataaa acaggcggga tagcatggct gagaagatcg 544201 gtgccgtagt aacgagtaag cttgcaactc cggcactaac tgttttttca ccgatgttca 544261 gcaaaatgtg atagaatgca aatcctaaaa accctaaaag aaaaatggca ggaatgtctt 544321 tcaagtcggg taggcgcatc tgagtcaaaa cagcaaaaag caataatgcc atagagccga 544381 ttaacaaacg aaataaagca aggtgttctg gcgtgtaccc ttcaagtcct gcgcgaattc 544441 ccggaaaagc agatgcccat aaaccaatca tgagactatg agatatcatt atttgaactg 544501 ttttctttcg cattcctctc actcctcttt acaaaaacca accagttatt taatgtgttt 544561 ctatactaat aaagatttga tgatatggct tcaaccagtt caatagattt tgacccaacc 544621 aatttatttt aaggagaccg attctatgag ctttccagaa gaaaaaaaga tgaaaaagct 544681 ccctaagtac agacaaatcg ttcattttat taaagagaaa ataggaaatg gagagtggcc 544741 gattggaagc aagattccaa gccagcgcac gcttgcaaaa gattttcagg taaatcggag 544801 cacagtgatt acagcgttag aggaattgat ggccgatggg ctaatagaag gcacaatggg 544861 gaaaggcaca gttgttatca acaacacatg gacactgatg gctaagaatt ctgctcccga 544921 ttgggatcaa tatgtcacct ctggcattca gatgccaagc cgaaaaatcg ttcaagagat 544981 aaatcaatca gaatcaaata cagaccttat acagctcagt aaaggtgaac tttcagctga 545041 gatttttcct ttggctgtta tgaaagagat gatggggaag gtatctcaac acatggaggc 545101 attcggatat gaagaaccaa aaggttactt acctttgagg gaggcattaa gcaactattt 545161 aaaaaccatt ggaatcaacg tctcatcttc ttccattctg attgtctcag gagcgttgca 545221 agccttgcag ctgatatcaa tggggctgtt acaaagagga tcaaccgttt atcttgatca 545281 gccctcctac ctttattcat tacacgtatt tcaatcagct ggtatgaagc tgactggact 545341 tcctatggat aatgaaggac ttttgcctga aaatgttcat ttaacaagag gagagcgggg 545401 aagggctatc ttatatacaa atccatgttt tcacaatccg actggtattc ttatgtctaa 545461 aaagcgacgg gaagaaatcc tagcagtaag tgagaataca cagcttccta ttattgaaga 545521 tgacatttat cgtgagttat ggatcgatga aattccgcca tatcctatta aaacaattga 545581 taaaaatgga cacgtactgt acataggaag tttatcgaaa acattaagcc caggtttgag 545641 gattggatgg atcgtcggac cggaaccggt gattgaacgt ttatctgaca ttaaaatgca 545701 aacagattac ggatccagtt cgctatccca gagagtagcg gcagagtggt ttacttccgg 545761 ccactaccag cagcatgtag aaaaggttag gcagcaatta aaggtgagaa gagaattggc 545821 cttgagtgct ttagaaactc atttgaaaga agtggcgaca tggaatatcc caaaaggagg 545881 gttttttgtc tggataaaaa tattgccttc catatcaatg aaattacttt atactaaagc 545941 cttatcaaaa gggattctga tcaatctcgg cagtatctat gctcaggaaa aagggaatta 546001 tattcgctta tcatatgctt atgcatctct tgaagacctt caaaagggga tttatgagtt 546061 gggtttaatg attaaagaat tggcaagcag gtaactttta tatccttaaa tggatgtttc 546121 actaaaaaag agatcaagcc taatgatcgc ttgatctgat aataacaagg gttactagaa 546181 tagaccaaat catggttcgg tcttaaaata atcatgtctc tgaacgaaaa gtctttccga 546241 cttctcttcc taaaccaaag tagtgtctga aattatagat aagcgggctc catttggaag 546301 ggttgatatg gttttcgtcc agaatgatac tttcctcggc atgaaaatgt agtgcctgcg 546361 tctctacaat tgcgaatgac gattcatatt ctggaagccg aatgtgtttc acttcggctt 546421 cgatttggat agggcattct ttaattcgtg ttggtgatac tgtttttgat tgtaaaggcg 546481 ttaaccctgc tgcctcgtat ttttcttttt tatatgtaaa tccgatctgc ttctttaaag 546541 gcggtatact cttttttccg ctataagatg aaattctttc aacgttttcc cataaatccg 546601 ggccaggcaa gtttatgaca cactctttgt gtctttccaa attgtcgatg gcttttcctc 546661 ccagtcctac tccaaggatt atataatgtc caagagccca agaagaagac ataggactaa 546721 tattagtggt tccatcctca ttcaatgtgg ttagaagaaa tgtcgaggta ccataataca 546781 tgatcttggg tttgatttcc ttaaatcgac gagtgtcttg ttttttgatg tccaacgttt 546841 tttcctcctt gtcacgctta catttatatt gtaaaggatt aacatttcaa ctatcatcga 546901 aatatgaatg taaggaggaa aatcatgaat cctaatattg caaaaatctc ttcgttgcta 546961 tcagatccct cgcgttcttc cattcttctc agtctgatgg atggaaggat acaccctgcg 547021 ggagagcttg catatctcgc taacattaaa cctcaaactg caagttttca cctgaataaa 547081 ttgcttgaag caaagctgat tagcgtagag aagcatggga gacatcggta ttacagattg 547141 gctgactcag atgctgcaaa tgtgatcgaa caattgcttc atattgcgcc taaagcaaaa 547201 gtcaaatctt taaaagagtc aaaagagaaa aaggacttgc atttcgcccg gacctgttat 547261 gatcatttgg caggttatgt gggcgtgcaa atggcacatt cactagttga gcaggggatg 547321 ttaaaaaaag ttgatttaaa ctttgaggtg acttcagagg gtgctttatt cttttcgaag 547381 ttaggcatca atgaagagca acaacggaat aagaggagag cctttgcccg ctgctgtttg 547441 gattggagtg aacggcagca tcatattgca ggagcattag gaaacgccct attggtgcgc 547501 atgttagaag aagaatggat cgttcgtatg cctaaaacga gagcgattag gattacacaa 547561 agcgggaaaa tcgcgtttga aaagcaccta aacgtgaaga tttaggattt tgaagcggaa 547621 acatcagatg atgaggcacg atatctagga ggagtaagat ttgttctaat cttactcctt 547681 cttcttattt tgaagcagct cgattcccca ttgcaataga gatgcggttc caactgttta 547741 tttgattaat gatcagaaca aggtcaacat attgttcctc atcataatgt tcccgcaccc 547801 gatgatatag ctcatcagga acccttttag atggaatgag cgtgatgtgt tcagatagtt 547861 cgagagccgc tttctcttca ggtgagtaaa aatcacattc attccaagca tgtaaacagt 547921 aaattcgctg ttcagtttct cccattttgc gggcatcgga cgtatgcata tctatgcaga 547981 aggcacagcc gttcatttga gagactctga ttttgattag ttctctcgtc gttcggttaa 548041 ttgaggattg tttcgtgtat ttctccatat ccatcatgat tttcatacct tcaggtgcaa 548101 tctcatagta ggacactctt tgactcataa agcaagactc ctttccatag aatacctaga 548161 ttgtatcccg gtattgatca ttttaccaat gtgcggtttg aatgacagct gtttcagcgt 548221 cttttggaaa gaagcttctt tgaataaaaa taagggtagc cagcaatgat gagtggagct 548281 gctaatgcaa gcagtatcca tgagcctgat tggctgtctc tagtgactct aatgaatata 548341 taagtaccga tcagaaaata taataaagca cctagaaacc aatacatgtt cattcctctt 548401 tttccttgct ttttggttgc gcatttttgt ctgtcatatg gcttaatcga tcagggttct 548461 gattttttaa taccttttcg gtccggattc cttttctctt taatgataaa attgtgagat 548521 caatcgattt caatgatgat cattccttca atgaatagta agttccttat gattttaaag 548581 gtaaatttga aaagataaaa cgtacataga ggcagaacgt tcatgtacgt ttgggcaatg 548641 atcacttgtt ggaaactcta atgtttccct gcacctgata ttgttgtgtt ccttctcttc 548701 ctataaaatg attggataca tgtatgtttg cacgttgaaa tatgggttcg attttcatga 548761 atctctattc ggtgaaacag gtaaaggaag tggataaggt ttgcttataa ggaatccttt 548821 taaagataaa tattactcac atgataggcg ggcattaaac atgcttgcac tcagagtgcc 548881 gggcctggct tttattctca tgatctatat agcctctatc gtgctgcaat ttgtttctgg 548941 gggctggtcc attttattgc tttatgcgtt taccatatta atcgccattt ttgctttgct 549001 tcattggcac tcatatcgct gggttaagaa aagagtgatt ctgtatttcg cggtacaagg 549061 tttgatcacc tttgcacttg ctaatctcat gactggcttc tttatacttg tgattatcgg 549121 cctttatgca tttttaattg gacaaattat aggaatggca gacagaagaa ggacttttct 549181 cattctttat ctattgctgc tgctggtcat aaattcggcg tatcaccttc ataaaggtga 549241 agttttgcat tttattgtta ttgctgcgcc gatcatgatt gtcatcatca cttatgccgc 549301 aacatttttt gcccaagtcg atgaaaaaat aaaagctcaa ttgactcttg aaaggctgga 549361 gctggctcat cagcaggtag aacagctgac gctgcagaac gaaagacagc ggatggcccg 549421 agacttacac gatacgcttg ctcaaggtct tgtcagttta aatatgcagc tggatgcgat 549481 tcatgttcat ctcgccaaag gcaacacaga gagagcgaag gaaatcatac aacaatcgat 549541 gaaaagagtg aaaagcacaa tagctgatgc acgttcagct attgacgatc tccgcagcaa 549601 atcagaagaa atcggtgttt taaaagaaag aattacctcg ctaatggatc attttataga 549661 gtcgacaggc atggcttgtt tattagatta cagattgcat caggtgctgg atgtgcgtac 549721 agctgaaaac tgttattaca tcattggaga atgcatgacg aatgcggcaa agcatgctga 549781 ggcgaaaaca atctggatat ccatttggga tgatgaaaag ggaaggctcc atttaacagt 549841 taaggataac ggcaagggat ttgatgttga aaaaggaaag aaaaagagag gacattatgg 549901 gcttcttggc atacaagaac gcgtcagggc aataaatggc caattcaata tcaagagtac 549961 aaaattgaaa ggaacacaaa ttgagatcac tgtaccaatt cagggagaga tgcaagatga 550021 ataaggtttt aatcgttgat gaccatcttg tcgtgaggga aggtctgaag cttttaattg 550081 aaacgaatga tcaatacacc attataggag aggcggaaaa tggaaaagta gcagtccgtc 550141 ttgcagatga attagaaccg gatatcattc tgatggattt gtatatgccg gagatgagcg 550201 ggttagaggc cattaaacaa ataaaagaaa aacacgatac ccccatcatt attttgacta 550261 catataatga agatcactta atgatcgaag ggattgaatt aggagcgaaa ggatatctgt 550321 taaaagatac gagttcagaa accctttttc acacaatgga tgcagccatc agaggaaatg 550381 tgctattgca gcctgatatc cttaaacgtc tgcaagaaat ccaatttgag cggatgaaaa 550441 agcagcgcaa tgagacgcag ctgacagaaa aggaagtcat tgttctaaaa gcaattgcta 550501 aaggtcttaa aagcaaagcg attgcctttg atttgggcgt ctctgagcga acagtaaagt 550561 ccagattaac gtccatttac aataaattag gcgcgaattc aagaactgag gcagtaacga 550621 ttgccatgca aaaaggtatt ctgacaatag acaactaaac tgcatatttg aaaattgccc 550681 aaacgtacat gcccgaatgt acgttttttt catttcattg tcaactacaa tgagaaagaa 550741 tgtgatcaag caatgtgttg aaaggagatt atcatgtcaa aaatgttata tacattagga 550801 ggatgggttg ctcgcaatcg cataaaagca atatgtgcgt ggatcgttgt gttagttgct 550861 gcgataggcc ttgcagtgac cttgaaacca agtttttctg aggatatgtc catacctgac 550921 acaccttcgg aaaaagcgat ggatgtgatt caaaaagaat ttcctcatgg tcctgataaa 550981 gggagcatac gggttatttt cggtgctggt gatggggaga aacttactgg gaagccagca 551041 aaaaaagcaa tagaagatac gttcaaagaa atcagtaaag atgattctgt tgactcgatt 551101 gcaagtcctt ttgtgacagg gacaatcgcg aaagatggca cagttgccta tgctgatatc 551161 cagtataaat catcagcaga tgatataaag gattactcta tcaaacactt aaaagacagt 551221 ttgaaaatgg ctgatgatga aggattgcaa actgagctaa gcggagatgt accgggagcg 551281 gagatggaga taggcggtgt ctctgaaatt gtcggcatta tcttggcttt tgtcgtttta 551341 gccattacat tcggttcttt attaatagca ggtttgccga ttttaactgc actgattggt 551401 ttaggtgtaa gtattggact ggttttgatt gggacacaag tatttgatat tgcttctgtc 551461 agtctttcat tagccggaat gattggcctt gctgttggta ttgattatgc tttatttatt 551521 tttacgaaac accgccagtt tttaggcgaa ggcatacaaa agaatgaatc aattgcgaga 551581 gccgtgggaa cagcgggaag tgcagtggtt tttgccggac ttactgttat cgttgcactt 551641 tgcggattaa ctgtcgttaa cattcctttt atgtctgcga tggggctgac agcagggctt 551701 agtgtactga tggctgtttt ggcttccatc acacttgtgc ctgcggtctt atcgattgca 551761 gggaagcgga tgattccgaa atcaaacaag aaaatagaaa aacaaagcac tgaaacaaat 551821 gtctggggac gctttgtcac caaaaatcct atcatgctaa gtgtatgcag cattctgatt 551881 ttgatcgtca ttagtatccc atctatgcat ttggaactgg gcttgcctga tgctgggatg 551941 aaagctaagg ataatccgga tcgccgggca tatgacttgc ttgccgaagg ctttggagaa 552001 ggatttaatg gccaattaac aatcgtagcg gatgccacaa atgctacaga aaataaggcg 552061 gaggctttcg cagatgcagt gaaagaaata aagggcttag accatgtagc aagtgtcact 552121 cctgcaatgc ctaataaaga agggaacttt gccatcatta cggtcgttcc tgaaacaggt 552181 ccaaatgatg tcacaacgaa agatttggta catgatgtac gcagtttatc agataaaaac 552241 ggagtagatt tgcttgttac tggatcaact gcagtgaata ttgacatttc agatcgcctg 552301 aatgatgcga taccggtgtt tgctgtactt attgttggct ttgcgtttgt attgctgacc 552361 atcgttttcc gttcgctgct tgtgccgctt gttgctgttg caggtttcat gttgacgatg 552421 acagccactc ttggaatctg tgtatttgtc ttgcaagacg ggaatctcat cgactttttc 552481 aaaatacctg aaaaagggcc gatactcgcg ttcctgccga ttttatcgat tgggattctg 552541 ttcgggttag ccatggatta tcaagtattc cttgtcagca gaatgcgtga agaatatgta 552601 aaaacaaaca atccagtaca agccattcag gctggattaa aacacagtgg tcctgttgtt 552661 acagcagccg gcttgatcat gatcttcgtt tttgcaggat ttatctttgc aggcgaagct 552721 tctattaaag ccaatgggct ggctctttcc tttggtgtac tctttgatgc ctttattgta 552781 agaatgacac tgattccaag tgtcatgaag ctgatgggga atgcagcctg gtatttgccg 552841 aaatggttag acaagattat tccgaatgtg gatatagaag ggcatcaact gacaaaggaa 552901 atacagccgg aaatagatca tgaacaaaag aaacaaatca gtgtgtaata gaaaaagcag 552961 atcttttatg atctgctctt ttgcttatgg tagtatttag aagatgaagt cggcagttaa 553021 aaggagacgc ttatggcgcc atcactcatt ttcgatatgg atggaacttt gtttcatatt 553081 ggcagaagct gcatcatact agcaggcatc ccaggagaag tgacatgatt ttttgacttt 553141 gcattcacta cttgatgcca aggatcttga gaatccttct tgaaaataaa ggattttaca 553201 actgatcata taagaaacct aaagaaacaa gcacacaaaa ccagctgcgg gttttgtcca 553261 agaaaaatag agtccataag agggactcta ttttttgaag tgcccggcta gaagcatatt 553321 gcaggacttt atgaatgcaa atcactatct tataagccct taccgtgaaa tgcctgtttc 553381 tgcattgaaa aaacgcatta cacgttcatt tacgtaagtg ggttgttcca tcgataaaac 553441 atgtccggca tttttaatga cttccgcctc aatatctgga acgaatgaag aggctcggtg 553501 cagggctgag tggggatcat agatgacttc atgttcacca agtaataata ggataggaac 553561 tcttgctgaa cgtaattcct catcggtaaa aacatacgga aatccgtcgg cattaggatt 553621 tggatttctt gatccatcct gccacattac ccctgcctta aactgcttca caaaaatcgg 553681 gtgcagcaca ttctgatcat tcatcatcca atttaagaat gtttcaactc catttgacgc 553741 tgtaaggcca agagcgtatt tgtagaaatc gtgatgaaat ggcaaaaacg tttctgccgg 553801 actcagtata gctgcgcttt ttactctctc aggcatacgt aaaaggaaat tcatcgtatg 553861 gagaccgcca agcgaaagtc cgatcatgtg ggacttttcg atccccagat tgtcaaacac 553921 atcaagaagc caattggcgt aatccgttct tgtaccgctt acattctcag gaatactctt 553981 gtttttatca cctatgatat caactgcata agttctgtat ttactgctcc aatcggcgat 554041 gttgggatac cacatcgtcg agctgaataa tgctccgtgg agtaatacaa gcggcggggc 554101 atcctctggg ccgcttgcaa tcacatgtgt ttgaccaaaa cgagtagata tatagaatga 554161 tttacaacgg accggccaaa gactaaggct ttcattataa gtttgataat agcggatacc 554221 gttgtcactt aattcgggaa tactagatga atggtttgac atacaaatgc ccctcccaat 554281 tttgtttaaa tgaatgtgcc gtttcgtgat ggggaatctg attttgatat aacagacttt 554341 atttacaata taatacagtt gttattagac gtcaaatcca agatgaaaag gaaaaaaacg 554401 attgaaacag attattgaaa atcaatataa cagaatatta acctcctttg tggagccgct 554461 tcattaaaac cgcaatccaa atgcatgaat cacaaaaatc acaacaggag ggatcaggag 554521 ggaaggcagc agattcagtg ttttgaactt cttgattcca agaatgctta gacctgaact 554581 gaggatgagt atgcctccca caattgtgat ttcattaata aggtctgtat tgattgcgct 554641 ctccattact tgtgcaaata aatagatgga gccctgccag gaaaataata caagtgcggc 554701 agccgctatt ccaaaaccaa aagttgaagc gagcacaatg gaggtgatcc catctaacat 554761 cccgtttgtc agaaggtatg tataatctcc atgcaaagcg gcttcaacag ggcctaatat 554821 tgacagcgaa cctatacaaa ataataagac cgcagttgat aagccctctg ctaaattgct 554881 tttagaaaat ttgttcacca gcttgttgaa tcgtaattct aaattgatga tctggcctag 554941 caaacctcca atggctaaac tcacgatgaa tagaatgggg tatttactat caggcaaatg 555001 ctgtgtaatg gcgttgatcc ccagtgcgac cgcagcgaat cccattgcct gcatcaaaat 555061 atcctggtat tcatctttaa tgcctttttt gaatatcccc ccgattatgc ttcctgcaat 555121 gatcatcact gtgttaaaaa tcgttccaaa cataagcttt ctcctccaaa aatcattcct 555181 gcataaaaaa taaaccctct agttagtaga gagtcaaggg agatcaaaac atattcatga 555241 gattatttga tgggcagcag gatttcagtc acgtaattat ctaggttatt cgtaatgcca 555301 taatcaatga gtgtgatttc gattgagtcc cctgctacct cataatgatg ttctttcata 555361 tatgccagta attttttgta gtatggttcg gcttctggat gtgacccttt aaacctaatt 555421 tgcagatatt ctcttgaagg aaagatgatt tctgaagaag ttttttcatt ttcatcttca 555481 agaatcataa atatactgga atatttgtca aactgttttg ctttcacatt tgctgcagaa 555541 atggataaac caatcttgcc tatgaatata tcttcgttta cattcaggtg ggttctcaat 555601 tcagctaacg aatgttcgat atcatggccg agaacatatt catgctgcaa ataggccaca 555661 cgcattgcgg gaagtttgat ttttgaaatt tgatgtaacg gcatgttaac ggcatcttct 555721 atatgtgtga tgcgtcggga gatctttcgt tcaatgcgtt ccaattcttt cttcttgcga 555781 tcaatttcaa cctgctggct ttttagtaaa tgaagaagag tgtttgtatt ttgagagtta 555841 taaaaatcaa gaagcttatt gattggcagg cctagggccc tcaaatactt gatggtatcc 555901 agccgctcaa actgttgggt agaataatat ctatagttcg tttgctcatc tttatattcc 555961 ggtttcaaaa ggccgatttc atcataatac cgaagagcag agattttcac attgaataac 556021 tttgacactt ctccaatcga aaaaaattcc ttcattctaa caacctttct gtcctatgat 556081 tgatatacac acattatata gtacggcgag tactaaaggt aaagtttgca gcataaagaa 556141 aaaactcctt ctaaaaagga gcttttcatt cttcgaaata aggatttaca tggatgagca 556201 cttcttctac atctgaaaac tgtcttttga tttcatttcg aatttcgcgg gcaatgtcgt 556261 gtccctgctt aattgtcaaa tcatgatcca aagataaacg gacatcaagc aatttatagt 556321 ggccatgttc tcgcgcgcgg attctatcaa ttcgttttac ctgatcacat tgaaaaataa 556381 cagctttata ttcctctatc agctcgggat caacactctt ttccatgagc acatcaacag 556441 acggcctgat taattccatt gaaatcttaa aaatgaggta agcaacgatt gcactggcaa 556501 tggcatcggc gtacaacaga taggaccatc cacggctgtt tccgatgata gccaacagga 556561 cgccgataaa agcggcaaga gaggcaacga tatcgccttt atgatcgtac gcaatcgcta 556621 taatcgcttt gctgttccat tttttccctt gctttataga ataacgatat aagatttcct 556681 tagccacgta cgaaatcaga gccgcaaaca atgcgctgta ttggggaacg cttggccctt 556741 taacaaagga cagaatcgct tctatgagga tataaacgga tacgatcact aagataattc 556801 ctacaatcgc ctcactaatg acttcagctt ttccgtgacc aaaaggatgg tcttgatcgg 556861 gcggtttatt ggaaattccg atcactgcca agactgcaat cgaagcaacg acatctgccg 556921 cggaatgtat tccgtctgca aacacggctt cactatcgcc taccagccca aaaaagacct 556981 ttcctgccat taagatcaga ttggcgatca atgcaatcaa agcaactttt ctgcttattt 557041 gttctctttc acttgccatt ttttcctcct ataaaactgc acaaaaaaat aggagtgctc 557101 tatatacgct ctccgtatcc tttcctgtgt aatcactttg tttatcatac caattcaatt 557161 tcgagtgggt ctatagcaac gttgtttcct gtttactaat aaataaggtg acagaaaaaa 557221 agttggagct atgctaaaaa ggtcatacag caaacaaatg agttcttatg taacaacagt 557281 gatgattcgc tattaaaatg ctgccgtcag tgaaaaattt ccacctaatt ttcaaaaacc 557341 tattgacatg agaagatctg tattttacta ttatctcata ttcaagatat tttaatttga 557401 gatatttggt cggaaagatc agcgatcaag cgcaactcta agtgttcaat cgttgtcagt 557461 tcttttacac aatattcaat atgatttttt ataacataat atctcgaatt cgagataaaa 557521 gggagtgtag cgtaatggct gaatttactc atttagtcaa tgaaagacga tctgcaagca 557581 attttctttc aggtcatcca atcacaaaag aagatctcaa tgagatgttt gaattggttg 557641 cattggcacc atcggctttt aatttgcagc atacaaaata tgtgacggtt cttgaccagg 557701 acgtaaagga aaagctgaag caggccgcaa acggacaata taaagtggtt agctcttctg 557761 cggttctctt ggtattaggg gataagcagg catatcaaca agcggccgat atctatgaag 557821 gtttaaaggt attggggata ttaaataagc aagagtatga ccacatggtg caagacaccg 557881 tttcgtttta tgaaaacagg ggagaacaat ttaagagaga tgaggcgata aggaatgctt 557941 cactttctgc gatgatgttt atgctgagtg ctaaggaaaa aggctgggat acctgcccga 558001 tgatcggctt tgatgcggaa gccgtaaaac ggattttgaa catagacgac caatttgagg 558061 ttgtcatgat gattacgatt ggaaaagaaa aaacagagag cagaagaccg cgcggctacc 558121 ggaagcctgt gaatgagttt gttgagtata tgtaaaagga gcggataaaa atggctaaaa 558181 aaacgatggg aattcatcat attacagcga ttgtcggtca ccctcaagag aacacagatt 558241 tttacgcagg agtgcttggg cttcgtttgg tcaagcaaac tgtcaatttt gatgacccag 558301 gtacgtatca tctttatttt gggaatgaag gcgggaagcc gggaacaatc attaccttct 558361 ttccgtgggc cggagcccgc caaggcgtca ttggagacgg tcaagttggc gtgacttcgt 558421 atgtcgtgcc gaaaggggct atggcatttt gggaaaagag actagaaaag ttcaacgttc 558481 cctacaccaa aatcgagcgc tttggggaac aatatgtaga atttgatgat cctcatggac 558541 tgcacttaga aatcgtggaa agagaagaag gagaggctaa tacgtggact ttcggagaag 558601 taacgcccga tgttgccatt aaaggttttg ggggtgcaac cctattatca gagcagcctg 558661 acaaaaccgc tgacctttta gaaaacatca tggggctgga gcgagtcggc aaagaaggag 558721 acttcgttcg ttatcgttcc gccggtgata tcggaaatgt gattgacctt aagttaacgc 558781 ctattggccg cgggcaaatg ggggccggaa cggtgcatca catcgcttgg cgggctaacg 558841 atgatgaaga tcagttagat tggcaaagat atattgcttc ccacggatat ggtgtaactc 558901 ctgttcggga tagaaactac tttaatgcca tttacttcag ggaacacggg gaaatcctgt 558961 ttgaaatcgc aactgatccc ccaggctttg cacatgatga aacacaggaa acaatgggcg 559021 aaaaactgat gctgcctgtg caatatgaac cgcatcgcac acaaattgaa caagggctgc 559081 tgccgtttga agtaagagag ttagattgat ttgacacata aaaaataaag aaacatatat 559141 tcaattgatg attgctggat ggtactgtca gcaaagaatc agataaaatc aaagatgagg 559201 agagatacaa atggaagatg caggactgtt gcttattcgt ataatgattg gtgtggtgtt 559261 tttgttttat ggcacacaaa aattattcgg ctggtttggc ggatacggga ttaaaggaac 559321 cggacaatgg ttcgaatcaa ttggggtgaa accaggaaac gttgcggccg ctctatcagg 559381 tcttggggag ttagtaagcg gaattctatt tattttaggc gtattcctcc cgcttggagc 559441 tgctatcata acaatcatca tgttaggtgc tatcgtaaaa gtccatggag cgaaaggttt 559501 tgcgaatggc gccggaggtt ttgaatataa cctggtgctc attgcagttt ccataggggt 559561 tgcactcatc ggttcaggag cttacgcttt gcatttttaa tacgaaagta tgtaagaaca 559621 gttgctgctt gtcagtaact gttcttttat tttcacattt tcggcaagct tgcaggtact 559681 ctgcaaagca aaaaagcgga tatcataaat ataaatctgt atagtgaatg atacgtattg 559741 atgagcttgg tcatgaaaaa cagacctatt tgaaggagta aatggatgaa agagatgaca 559801 ggattacatt cattagtttc tatagaaaac tttatcaaac agcacaaatt cagttttatt 559861 tatatatcaa ggcctggctg tacagtatgt cacgcagttc tgccccagct cagaatagta 559921 ttggatcagt ttccaaacat caaattgggg catatcaatg ctgacgatgt agcagaggtc 559981 gccggcagat tttcagtttt caccgttcct gtgcttcttt tgttcattga tgggactgag 560041 tttctaagag aagcccgttt tgttcatttt gaacagcttg aacaaaagct gaaaagggtt 560101 tatcgattat atgaaggcga ataaaggaat aaggcaaaaa aagaactcaa atgagttctt 560161 tttttattct tcactaggcg aagaagggtt atcaacctgc ccttgatcac ttgtatcatt 560221 atcacaactt gctgaaataa taattgaatg agaaggagag taatctccta atgtgaaatt 560281 cactccgtaa tttttgctgt tcgcagtatg gctgttttgc aagttttgtc cgatatctgt 560341 attggcgttt tgtgtcattc catttatcgt gagatttgag atgttgattt gagatcgcat 560401 gcttcaaaaa ctcctttcac tcagaagtag ctgtcataaa ggacgctggc agtctattta 560461 cttctatgat attgcgtttt tatatcattg catcaacata atggtaaaaa taatagcgag 560521 tgaatgatca tcttttgaag atgatcaacc tatcagcaga aataaagccg cctgataaag 560581 aggcggcaga tcgttatatg tcatctatga atttgatgta tcgtttttcg tttgcctgaa 560641 ggataagata gtcgttttta atgatgagta ggagcctata gcagcgtagc cataaaacca 560701 gcccataaat acgccagaaa agaggctgtg tcgatggctt atgaaaacag aaatgacaag 560761 gcctgttatt aaggcaactg acggtacaaa agttttgggg attttcaata atattttgag 560821 gatttgggtt atcaatatga tgattggaac agctatcaca gcatcccaaa agttcgtgtg 560881 aataattgga aaagccatac ggcacctcat gaagtgttta tttcttaatt tttacgctaa 560941 aagcttggaa agcagctctt ggatcgcata tgttacattt tgggcttgat tggcggagct 561001 tgtttggctt aaagcattgg attcaaaaac caaacctgta ttactcccac cggaaccctc 561061 tgttgtttta gacacagaga acgggctgat ggaaactgca aatccgttat taaaaacgct 561121 gttcccggat atcgaatgaa tataaactgg gaatttcatc attcatctct cctctctgtt 561181 atgactgttt atacaatatg gtgtgtgagc agcagttgct taaacaaaac ggcaaaaact 561241 ttcagtaaga gacaaaaacc tgcaaaatgc cacaagcgcc ttttgttaat gcagcttttt 561301 agggacgttt tttttatttt ttttgccaac ttcatcaaaa atattctgat tgccagactg 561361 ggcttgtccg tccttattta tgaaatcggg gtgaatgagt tttttcagat ccctgactgt 561421 taaaggcttg gcgtcatcag ttaattctat tcctaattgc ccgtttgcct ctaatgtcgc 561481 aattttgaca tcttgtatag ccgtaacgcc gtgaagcctt agctgcattt caagctggtc 561541 agctgtaagt ctcatcttct ttaagttttc gatatgaagc tgtccgtttt caatgacgat 561601 ttttgctttt ccggttaaca tcttttcaat ggtgttcgat ttcatttgga tccattccat 561661 aacgatgagt gtgcttgtga aaattgccgc tgcaattaat gttttgaaga ggctgtactc 561721 gatgattggc tgaacgataa tagttccgat cgaaatcatg acaaccgttt gagtcgacgt 561781 catttgtgcg attgatttcc ttcctgaaat tctcagcaaa atgaccccgg ctacaatgag 561841 aacaagagat tcccaagtga aattcatgct accacctgac caatgatgaa ttagatttgt 561901 catgggattg gcttttcttc cggccaatcg caatttaata tatccgaaag gcagtcggtt 561961 cattctgtcc tgaaccgaac aatatttttg gtatagatgg atatattaag ccaaacaatg 562021 atagcaacag gagttttttg gccgaaacaa tctgggaagc ggggagcgcc ataacatgat 562081 tgaacttgaa gttgtcatta gaacggttgc cagctttggc ttgctgttaa tcgcagaacg 562141 aattttaggc aaacagacaa tctctcaaat gacgattttt gattttattg cggcgatcac 562201 actaggggcg attgctgccg gattagctta caatacttca ataaaaccgc acaatatggc 562261 catttcgttt agtatttttg tgctaaccat ttttctaatt tcgtttctgt cgataaagaa 562321 caggaagctg aggaaatttt ttgccggaga tccaacagtg ctgattcaaa acgggaagat 562381 acttgaatca aatatgagga aaatgcgtta cacacttgat tatttaaatc agcaattacg 562441 ggaaaaagaa atatttaata tcgaagaagt tctttttgcc attcttgaaa cgaatggtca 562501 gctgactgtg ttaagaaaac cgcaattccg gcatgtgacc aaacaggatt taatgattgc 562561 ggtaaaccaa gaacaaaggc ttccgataga acttattatg gacggagaaa tcattgagaa 562621 taatttaaag cagaatcgtt tgacggaatc ctggcttttg gaagaattgc gaaaaagaga 562681 cataaaggtg aaagagaccg tgtacgcagt gctgctgggt aatggggata tttatgtgga 562741 tcaatataaa gaccatatat cagtccctat ggataaggaa tgaaggaaca atcaatctta 562801 aagcccctta ttgaacgcaa cggtttcaac ttgtcttggg tacgaaatat gcagaagccc 562861 gtttaacagc tgaatctgta acaaatgagt ttcagcggct tcgggaagct gaatgattcg 562921 ctcaatttct ccgtaatacc gttcacgcag cacttccatt tcggctggaa aaacaggcgt 562981 gatcgttcct ttgatcagca gctgggtttt agacagtaaa cggatcgtta attcttcctc 563041 atacacaccg ggcatttcca caatgataaa attatattcc tcatcttgat aaaagtcgta 563101 aacaaacgta gaagcttcgg aatcaaaaaa atgttccggg gctttatatt tgagcacatt 563161 tgtccaaaag tcactttgtt tatattcatt cgtaatctca agccactttc gaattttttc 563221 gaaatccata tgagattctc cttaaatttg atttgaaatc ggcgcagaag ggtttccgat 563281 ttggtcttgg tcactaacgt ctgaatcaat atttccagtg tttaaaagtg aagacgtagg 563341 cgaaagatcc cctaaggaaa agtttgctcc aaaatatttg ctgttcgcag tatggctgtt 563401 gtgcacagtc ggaccgacat ctatatttcc gttttgcgtg acgccgttga tcttaatatt 563461 tgcgatatta atttgatatg gcatagacga aaccccttta atctaaaatt ggcggtggtg 563521 caatcggagg agcattaacg ttggatgtat cagagttgcc gatagatgtc tggtcattta 563581 catcaggatc gtttaagaag ttttccatta cggattctgt aggtgatgta tcaccgaaag 563641 aagagttggt cccttgagat ttttgattgt tggtagggct gttataagca gcttcgccta 563701 ttgtaattga accattgccc gaaatactgt tgatcttcaa ataatatagg ttgattactg 563761 tagacggcat cccatcacac ccttccatct ttctgtacag tacattatgc gccgctgcac 563821 ccaattgttc cttgcattta cgggcaaaac tctatctggc cccggagtga tgctcaatta 563881 tcagtgaatg aaaagccatt gatataggaa tcaatgaatt gattcagtta ttcgaaatgc 563941 atgagacctt ttaataaagg aagctggcaa acaggatcag tttgaaataa ttgacaatga 564001 agctaatgcc atgaaataat actcgtgagt aacattactc gtgggtatta tttttggggt 564061 ggtcctagtt gaaaagtaaa ggagtagaaa gccgaaaacg attacttaaa gctgccgcta 564121 atgaattttc ggttcgggga ttccatgacg cgaaggtaag tgaaattgtg aaaaaagctg 564181 ggttcacgca gccttcattt tacctgtact ttcaaagcaa agaagccatc tttgccgagt 564241 taataaccga ttttcactct cgagtcagaa agctgacaga gtcacttctt ctggaaaacg 564301 gattaaacac ggaggatgtg tcaaaacggg tactgctagc tgtagagact gtttttcaat 564361 ttttggatga ggacaaggat ttaaccaaga tcggcttttt tctcaacccg gaagcaaaac 564421 aaatgaaaaa agacttggcg atggttttga aagagaactt agaagcagaa cagcggcttg 564481 gctattttca ctctgaactg gatatggaaa ctgtcgctga gtgtttggtc ggcatgattg 564541 aacatttaac cgaatcattt ttgttaaccg gaatcaaaga tccggcaagc ctcgcagcag 564601 aggttgtgaa tcttttaatt tacgggatgc ttccgaaagg gaatgatgta agatgatatc 564661 tattatgatg aaagtcagtt tggcagtttt tatgcttgcg ggaggcatca taaaggtaag 564721 ccgcgttccc tttcaagttg agcattggcg gcattatcaa tatccattat ggtttctgac 564781 tgttactggc attcttgaaa tagccggggc acttgctatg acagcgggaa tttggaatcg 564841 gtatgcagca attggagcag gtgttctgtt tgtcgttctc atggcgggag caattcatgc 564901 gcatatgttt cgagcaagac aatctgtcat catggcgata caagcgatga tttgtttgat 564961 tgtttcaatc atgatcatca tggggagtta cacgtaagct tttcactaat gtttaagaac 565021 aagcccattt gcaggaaatc tccttttctt atcgaataat agaaagtcca ggaattaact 565081 gaatcagtaa aatagagctc catttctgtg ttattcgtcc ggcatcagct gggctttttt 565141 tataaaggag gaatacagga tggcattcac tttggaagac atgactgagg aagagttcga 565201 agcctttcgc gggatgtccg tgcaaaattt tgcgaaacaa aacataacgt caggaacttg 565261 gacggaaaaa gaggcatttg agaaatcgga gcaggcatat gagaacatga ttccgaatgg 565321 gcgagacagc agcaatcatt atttttggaa catcacaaat gaccaaggag aaagaatggg 565381 ctggctctgg ctgtatgctg atccattaca tccgcaaaag gaagcgttta tctattcctt 565441 tggattgtat gaagcctttc gcggaaaagg acttgctcaa ttggcgcttc aaacgcttga 565501 tgaaagagca agagagcttg gtgcggaaag gctggctcta catgtatttg cacacaacga 565561 gacagccgtc tatctttatc agaagatggg ctatgccatg accaatatac gtatgcggaa 565621 acagctatgc tgaaaagccg cttacgttac ccaaatacaa catgcctatc tggaagcggt 565681 ggcagggtac tataagtcat cattagaaag attaaggtca tgggaggctt gaacatataa 565741 agaaaaagga caacagctgt tgtccttttc aatgccgctt gaactttctc cctcagtctt 565801 ttttgtcttg atgatccagc tcttttattc gtttcgtaag ctcattgaaa gcctgatcaa 565861 gctccttata ccctttatca tttggcgtca taaaactgag ctttcccagc acttcttgtc 565921 tttctgtctc aagctttaac cgaagctcct cccgctcatt tctttctgaa ggaacgtcgt 565981 ttaactgctt ttcgatgccg ttgtttgaga tgacgagttt actgtttgtt gttttttcga 566041 gaaagtatcg gtcatgtgaa accgccagca atgtgccgct gtattgtgac agtgtttctt 566101 ccagctgttc gcgtgacggc aggtcgagat ggtttgtcgg ctcatctaaa atcagcacgt 566161 ctttttcctc cagaatatat gccatcagct tgatctttac acgctcaccc atactcatat 566221 gcttgatcgg ttcagtccat tgggcggctg taaaacctaa gtgcctcatc agattttgaa 566281 cgtgccccct tgctttgaat gtttcattct caaataactc ttccggtgtt tgttctaaag 566341 gcaaatcaaa cacctcctgc gttaaatagc cgatgtttgc ggacggcgac acccatacac 566401 ttccttctgc tgtttcctgt cccagaatga tgttcagtaa tgtcgttttt ccgctgccat 566461 tggggcctat gatcgcaacc ttttcgccgt gctgaattgt aaagtttgcg tttttaaaga 566521 gagtcctttc tccaaacgct tttgttacat tctgaacttc taaaaaacgt tttcctgttt 566581 tgtgggttgt atcgattgaa aagcggactg tatattctgg ggtaacgggt tccgcctttg 566641 ctttttcaag ctctttttca agccgcttct gcttggattt tatctgggca tccgtacgct 566701 tcgcttttac ccggtgatat tctttaaacc cttccttttt cgtcgattga gcatgggctt 566761 tttccgacca agaagcgagc ccattcattt gtgcttcaat ccgttcaacc attttttgct 566821 gcttttcata ttcacgctgc tgggtgagtc ttttcttctc ccggaacttc atatacccgg 566881 agtaattccc tttgaattca atcagcgtct gatcctcaag cgaccatatt tttgttgcgg 566941 cttcgtctaa aaaatatcga tcgtgagaaa cgagaatcac agtgccgtta taatgtttca 567001 gctgttggat gagaaattgc aagctttttt catcaaggtg gtttgtcggt tcatctaaca 567061 gcagcagatc tgcatcctct gatagtcctt tcgccagccg cgctttcagt ttttcaccgc 567121 cgcttaactg atgaaaatca cgaagaggca catgccattt ctccagtaac ttcttttcgg 567181 caggtgtctg atccgcaaag gaatacgccg cggtttcctg ttcaaccaaa gccagtttta 567241 tatccttccg aaggatttga ccctgtgcag gggctaagtc attgtgaatg aggtgcagca 567301 acgtagattt cccagcgccg tttttgccga taatcccaat gatatctcct tgctgaacac 567361 tggcgtttac atgtttaaaa acagtttgat cctttacttc atagctaacg tttgttaatg 567421 ttacgatctc tttcatccat atccctcgct ttaaagggag aataaaaaaa tcctcccaaa 567481 tgtgttggaa ggattagccg tgcctgtgca tgatcaaata agctattttt tataaatagc 567541 agtgtcgtat atatagaaaa tgggcagact aatcctattt tttgatttga aatattgatt 567601 tcaaacggta aaaataagat tagttaatca ttgtccaccc atcatccctt cttgttttga 567661 ttacaaacac tatagcatac ctttaaattc aaaagcaaag gtcattttca tcaaaaaaac 567721 tcctgctctc atttttgagg caggagtttt gagtcttatt gatgcttcgc ttttctcact 567781 ttataaatca caatcagcaa aataaaccaa accggtgtga caaataagga aacacgagta 567841 tcctgtgcca gtgccagcac aaccagaaca aacgccagga acgcaagaat caggtaattt 567901 gtaaacggat aaagcggaag cttaaacttg tttgttttcg ctaattcagg tcttgttttg 567961 cggtatttca tatggcagat gaccgtaatc ccccaaatgt agataaagca tacggttgaa 568021 atacttgtga tcagggtgaa tacgccttct ggcatgatgt agtttaacgt aacaccgatt 568081 aaaatcacga tagctgaaaa gaataaagca tttctaggca ctttacgctg agtcagtttc 568141 gccattgact caggcgcatt gtgatctttc gccagggaat agaccatacg gcttgtactg 568201 aatacagcgc tgttgcatgc tgaagcagcg gatgtcaaca caacaaagtt gataatactt 568261 gcagccccga cgatgccaac agcgacaaat acttgtacga atgggctttc gctgggattg 568321 atgatatccc aaggatagat gctcataatc acgagaagag ccccgatata aaaaagcagc 568381 acacggacag gaatattgtt gatcgcctta gggattactt tttcagggtt ttctgtttca 568441 ccggccgtaa gcccgacaag ctcaatgccg acaaaagcaa acacaaccat ctggaacgag 568501 aggataaacc cgtgcatgcc attcgggaac aggcctccgt ggctccagag gtttgtgaag 568561 ctggacactc ctgagcttgt ggaaaagcct ttgaaaatca tcacaaggcc aatgacgatt 568621 aacgccaaaa tggcaatgac tttaatcaaa gcgaaccaaa attctaattc tccaaaaagc 568681 ttgactgtcg ccagattcat aatcagtaaa ataataagag cgattaagcc aggcacccat 568741 tgcggcacac ccgggagcca atattgagtg tagagcccga ctgctgtcag atcagccatc 568801 gcaatggaaa tccagcagaa ccaatatgtc cagccggtga taaaagctgc catatcgcct 568861 aggtagtctt gtacaaaatc cacaaaagag tgatagttca agtttgataa cagcagttca 568921 cccagcgatc tcataattaa aaagcaaatg atccctgtga tcatataagc aaataaaatc 568981 gaaggtccgg caaaatgaat cgatttgccc gagccgagaa ataagcctgt cccaatggct 569041 ccgccgatgg cgatgagctg gatatgcctg tttttcaagc ctctctgcaa cgtttgctga 569101 tttatattgt ctttcgtcat gtcgtctgtc actttatgtg ttcctccatt gaaaattgtt 569161 tattgagtca gcaatctatt tttaatgatt attataacac taaaatttct atctttttta 569221 ctaaaaaagg attgatgaaa agaattttaa tgtgatttgg actatttccc gaaaaaagcg 569281 gctccattta gggagccgct tttttatgct ttttcagttt ttgtcataaa caggtagagc 569341 ccgtaatctg tcggtgcgga tgcgtagcct gcctgccgca gcattgctgt gatattgccg 569401 cggtggtatg tcccgtgatt gacaacgtgg ggaagcagtt cggaaacagt tgttttcatg 569461 attccgcttg agggattttg aatctggagt ggcttattga gctgttcttt ttgctgtaaa 569521 aatagtatat agcgctcgga taacctcaga aaaaggtctt ccatttcctc tatttcttta 569581 gcctctgtct gttctttaag ctgttcagct aaagccaacg catcgctcaa ggttttgccg 569641 gaaaacactt caatccagcc gagatcagaa agataaacat gagacaatac atgggatatt 569701 gacggaaaca cgctttgaat ttcttgatgg tatatctctt ttggaagctc ttttaatcgg 569761 ttgaatattt gttgattggc ccagacgtta tattcataca atttgaatgc aaaatctgac 569821 atgttaaaat tccccctttc gtgtgtatag ctttcattat acacgaacat gagttcttat 569881 gtagagtgct cgaaaataaa atttgttgac atatatagtt tagaggaata aactaattga 569941 cattgaacat aaagtttagc ggggtaaact ataatgagga ggggaagata ttgaatgaac 570001 aaaagctatg tcaggcgata aacctgtttg tggaagtcct gcttgaaggg acagaatttg 570061 tgcatcgtga aatcaatcag gatgtcttca agcatatctc aagggaacag gcagacctgt 570121 tgaaaatttt aaaagtcaag ggcccaacct ctcccggcag cctggccatg taccaaaatg 570181 tacataagag cgcgatctct aacagactga aaaagctgct cgaaaaggga ttggttcaat 570241 gggacgactg tccggaaaaa agtgataggc gctctaagct tattaacatt acacccagtg 570301 gtgaacacat actagaagaa ttagattctg ccatctttaa cgcgctcaaa ccgttgattg 570361 atgatataga tgaggaacac ttacattcta tcatcgagat attcaccatt ttaaaaagca 570421 aatttaaagg aggagattct gccgaatgag agcaatcatc aaattcaagt gggcaattgc 570481 agccatagta ttagcactta ccgtcgtttt gagtttgttt tctccgaact taacggagct 570541 ggccaatcaa aaggggcagg cccagcttcc cgctgatgct gtttcagaaa gggcaaacgc 570601 cattttaaaa caagcgggag aagacaataa ttcgatcagt gtagtcttta cattagacaa 570661 cgctataaag aaagaaacag agaatcagct ccggataata attgataaaa tcaaaaagat 570721 cgacggtgta gaagaggtaa catctcctct gtcagcggaa aaagaagtca aagaccagtt 570781 gatgtcgaaa gacaagaaaa ccgttctcat gcctgtcacg attacaggtt ctgataaaaa 570841 ggcggaaaaa attgcggacg agatttatca aatcgttcct gatgacttga cggcatatat 570901 tacgggagct tcccttatca accaggattt cgctcacagc tcagaggaag ggcttaagaa 570961 aacggaagtg ataacagtct gcctgatcat cggtttactg ttgatcgtgt tccgatctgt 571021 tgtgacgcct tttatcccga ttgtggttgt cggtttttct tatctgatca gtcaatctat 571081 actgggcatc cttgtataca atgttgattt tcctatctcg acgtttacgc aaaccttctt 571141 agttgcgatc ctgttcggca ttggaacaga ttactgcata ctgcttctta cacggttccg 571201 tgaagaattg gcaaacgggc atgataaaaa agaagcggcg cttatcgctt accgcacagg 571261 gggaaaaacc ttatttatca gcggatttgc ggtattgatc ggattttccg ccttaggatt 571321 tgcgaagttt gcgattttcc aatccgcagt aggggtagca gtcggtgtgg gaattttaat 571381 gatcatcctc tacacactgc tgccattatt tatggtgacg ctgggtgaaa aattattctg 571441 gccttctaag aaagtgctgt cacacagtga taacaaacta tgggcgtttc tcggcagaca 571501 ctccgttgcg cgtccgtttc tgttcattgt catcacggtg gtgattacgc ttccgttcat 571561 cttgacctat gatgaccaga tttcattcga ctcaactgcg gaaatcagca gcgattataa 571621 atctataaaa gctctcgagg ccattaagga tggattcggg gaaggaaaag cgttcccgat 571681 caatgttgtc gtaaaaggag acaaagatct tacaacagct gatacaatcc cctatctagg 571741 aaatatcagc aaagcgatcg agaaagttga tcatgttgac tctgttatga ccattacgca 571801 gccgactggt aaaaaaatca aagatttata tattgataac cagctaggat cggtttcaga 571861 cgggctggat aagacggtga aagggattgc cgatgtccaa agcggattaa cggatataga 571921 aaacggactg aatcaaatgg cagggcaaac cggctcggcc tcaaatggag ggtctggcgg 571981 ttcactgggc gatgcggcag atggcttggg caaaatcaat cagcagctgc agctcgtgag 572041 caaacagatt tcccaaaccg gcaataccgc acagaccgtg cagcagctta cggcaataag 572101 cggacagctt ggccagattc aaaccggcct tgaacaagcg aaccaacagc tctcaggcca 572161 gcaggcacaa gccggaacgc tgacagaaag cctgaaaaag ctgtccgaag gcgtgaaaag 572221 cgcaaatgag ggcctgacga aagtctctga cggtattaca gcttccagtg atatattaga 572281 ggacatgagc aaaagtccaa ctgtaagaga tactggcata ttcattcctg atcaagtaat 572341 gaaggacaaa gactttaaga agtcaattga ccagtattcc tttgcagacg gcaaaggtgt 572401 tcaattaagt gtcgttctgg attcaaatcc gtactcagaa caagctatta cgacaataaa 572461 ccaaatcaaa aaagctgtcg caaacgaagt tgacggcact cctttggaga atgcacagat 572521 cgtgtacggc ggggtcacga gtatgaatgc ggacttaaag gagctatcca caacggactt 572581 ctccagaaca atggtgatta tgattatagg cctgtttatc gtgttaacca ttttgttccg 572641 ctcaatgatc atgccgattt atatgatcgc gtcattgctg ctgacgtact atacgtcgat 572701 atccataaca gaattaattt ttgtaaacgg cttaggaaac gcgggtgtca gctgggcagt 572761 gccattcttc agctttgtca tcttgatcgc gttaggggta gattattcga tcttcttgct 572821 ggatcgattt aaggaagagg tgcaccttgg cattgagcaa ggtgtcgtca ggtcaatgag 572881 caaaatggga tctgtcatta ttacagctgc cattatattg gccggtacgt tcgcggcgat 572941 gatgccttca ggtgtcaata cactgatgca ggtggcaagt gttatcatca tcgggctctt 573001 gctttacggc cttgtcatac ttccgctctt catcccggca atcattgcga cctttggaga 573061 aggaaactgg tggccgttcg gcaggaagaa aggaaaagag taatcgagag aagagtgatg 573121 aatggtcatc actctttttt catgactaaa cgactaactt cagacgtgtt acccaaaaag 573181 atcagacgat caaacggcgg ctgtacttaa aaacaaagag cccggaaaac attcccgggc 573241 tctttgtttt atttccattc tgcaattgta tcaatcggca gacggtagga agcatagcct 573301 tcgtctgctg cttttccgat agaaagtagc ataaccggta cataacgttc tttatctaat 573361 ccgaaggttt ccgcgatgtt ttctttatcg tatccgccga tcgggtttgt atcgtagcca 573421 tgcgcgcgtg cagtcagcat cagctgcatg gaaacaagac ctccgtcaat caggatcgtt 573481 tcacggttga cctgtgccgg aagcttttca aaatgtgcgg tcagcgcggc gatttgtctg 573541 tctttgacct cctgcggcat gtaaccaagt tccacggctt ttgaatagat ttcttctaga 573601 tagtctgcgt tgttcatgtc tgcaaataca gcgatgacag cagatgatgt tgtgacttgt 573661 gtttggttaa agcttgcaag cggtgcgagc ttttcttttc cttccgggct gtcaatgaca 573721 agaaaacgcc atggctgcgc gttaacagaa gatggggcag ttgttgcttc ctctaagatc 573781 tctgtcattt cttctttgct gatttttact gccggatcat agttgcggat agaacggcgg 573841 cctttcataa tttccataaa atcgtttgtt ttgatcatgt tgatacactc ctcttaagct 573901 tcgatattat ttatattgtt tcgcatgcgc gccagcacat caatgagcag gcggcgttct 573961 tctgcgctta catttgcgag catttccttc atgaaacgct ccttttcctt cttagaagac 574021 tcaattcgct ctcttccttg gtctgttaac cgaacaaggg tgatgcggtt gtcctcaggc 574081 ttgcgccgcc ttgataccat gcctttggat tccagctgtt tcaggtgtct ggtaacggct 574141 gcgctatcga tatttacttt cttttgaagg tcgctttgac tgatctcatc tgcatgataa 574201 agcaatgtca gcaattccaa acgagattgg ctgatgcccg tgcatgcctc gaacttcacg 574261 ccaatcacct tgttcacgcc ttgcagctga tataaaatct cggcttcctc tgaacaaaat 574321 gacgccaaaa cccatccctt ctttcctgtc aaaactatta attgatatat caatgattga 574381 cacgtcaatt aatatacaac gattgatttc atcttgcaag ccatttgcac ttttgaacaa 574441 cctcccagcg cataaaattc gctaggctag aacttagcaa aaaaagctgg ccgcttcttc 574501 agatgatgct ggtcacgatg attccctgca tcattcccat ttataggtgt tcggaatatc 574561 actttgccgg cccgtgctca agcggctttc acaggctgaa agttatgata caatatacaa 574621 atgtttcaca gcttcaatcc atagttggag ctgacatcca ttatataagg gactaggttg 574681 aagggaaggt ttgataacat gctgcacaat ccaactggaa aagaacgctt ggcactagcg 574741 tttctgctcg gcatgcttgc tatattgggc ccgcttaata tagatatgta tttgccaagt 574801 tttcctgaaa tcgcgaaaga tttatcagca agtgcttcac ttgttcagtt aagtttaaca 574861 gcctgtctgg tcgggcttac gatcggccag ctgattgtcg ggccggtcag cgatgcgcag 574921 ggaagacgaa aaccgctatt aatctgtatt tttttatttg cgttatcttc tctgttttgt 574981 gcactgtcgc ccaatataac aactttagtg gctgcgcgtt ttttacaagg cttcactgct 575041 tctgcagggc ttgtgctgtc tcgcgcaatc gtccgcgatg tgtttaccgg aagagagctt 575101 tctaaatttt tctcgctgtt aatggtcatt accgcggtgg cgccaatggt tgcgcctatg 575161 acaggcggtg ccattttgct tttgccgttc gcaacgtggc atacaatttt tcacgtctta 575221 atgatcatcg gatttttact agttcttctg attgcattga ggttaaaaga aacgcttccg 575281 ctggaaaaac ggattccaag ctcaatcgga acatccgtca aaacgatggg cagcctgctg 575341 aaggatcgat cctttatggg gtacgcgtta actgtcggat ttattcacgg gggaagcttt 575401 gcatatgtgt ctggtacgcc ttttgtatac caggatatct acggggtgtc tccgcaggta 575461 tttagtattc tttttggcat taacgggctg gcgattatat cgggcagctt tatcatcgga 575521 cgctttggcg gaatcattca tgaaaaaagc ctgcttcgta tagcggtcat tacggctatg 575581 attgcgacgg ctgtgctatt aaccatgacc atgattcacg gtcctcttgc tacattagtc 575641 atatccattt tcatttacat gattacgatc ggcatggttc tgaccagcac gtttacccta 575701 gccatggaaa agcaggggca ccgcgccgga agtgcaagtg cgctgcttgg aatgcttccg 575761 ctgctcctcg gttcaatcgt gtcaccgctt gtaggcatta atgagacaac agccgttccg 575821 atgggagcca tcatgtttgt gacagctgtc atcggctcac tggcgttttt tggattaacg 575881 aaagaacgag tagggcagaa ttcataaaaa aacctgacat gacgtcaggt tttttgtttt 575941 atttagaata acaacagcag gcctgcaatc gccggagtca aaaagatggc tgatttcaaa 576001 accacctttg gcatgaggtt ggtgaatttc gcgcctacat aggccccgca cattgtcccg 576061 accagaactt tgacaagtaa aacgtaatca acaaaacctt ctgtaatata tccgatgcct 576121 ccacctacag ccagagggat gatcacaagc atcgtcgttc cgacagaatg gcgaatggac 576181 agattcagca taatcattaa accgatttga ataaaaggtg ccgacccgat gccgaatgtg 576241 ccggaaagaa cgccggctgc aattcctaag atgaccgctc tcgtatacgt tgaaagagtg 576301 ctttgattca cttgagcctt ctcttttaaa ataaataatc tgattaaaat gagaattgct 576361 gataaaaata acattccagc cgtcaaataa tgaagcaaat cagccggaat aaaagaagtc 576421 agcttggcgc cgaaaaatga gccaaccgca gcaaagcctc cgactattaa gccgattttc 576481 atttgaatgt taccctcgcg atagtggctg tatgcccctg ataagcttgt aaaagccatg 576541 ccggcaagcg aagtgcctaa agccgtatga atcgggatat ggaaaagaag cgttaaaagg 576601 gcaatgacaa agccggctcc accggcgcca ataaagccta aaataattcc tagaagaaac 576661 ataacaagaa taatgagcat attttttcct ccattgaaaa gatgtaaaaa tgtaatcgtg 576721 cgctattctg gcggaggtat ggtgtcctat tgacgaagaa aaacacgccg ttttttcagt 576781 tgccagtagt ccgtcgaccg tcgttcagca aacatatcgt acctcaaatt cagggatctg 576841 acaaggcagt ttgttgcttc ccattaccat ctgttatatg attttgatga agaaaagccc 576901 ttgaatatat tcaaaagagg tattatatat ggacgatttt aaattagata agccgactcc 576961 ctactacctg caattttata accagctaaa aaaaatgatc ttcaacggga cttttaagcc 577021 tggggaacgg ataaacgaaa cacagctggc gaaaagcttt ggcgtcagcc gctctccgat 577081 aagggaagcc atgcgattgc ttgagaaaga tggtttgtta aaagcggatg accgaaatgg 577141 gttttcgatc acgtcgttaa cggcaaaaga tgtagatgag atttataaaa tcagaattcc 577201 gctggagcag ctggcagtcg aattagtcat agacgaagcg gacgaagaag agctgaccat 577261 actcgaaaaa cagcttgaag aaacagagaa agcgattcac aacggcacgg aagatacaga 577321 aatcattcgt ttaaaccaaa aatttcatga gctgctggtt gatttcagcc ataacagaca 577381 tttgaaaaat ttgcttgagc atgtaaatga cctgattcat ttttgcagaa tccttaatta 577441 taccggcgac caccgcgcag aaacgatact gcgtgagcac cgcaggatat ttgaagaagt 577501 gaaaaagaaa aacaaagaag cagccaaaca acatgtgctg gctcatttca atcatgactg 577561 tgagcatttg aagcatgtgc ttgaagaagg taaagagaat tgatttgtat gatccggtac 577621 caagggagag cagaaccctt ggtatttttt tatgtattca ccacatatct aagaggcccc 577681 gttaataaga ttttatgatg gtttgactaa cgaataatgg gggttaaata tgtttatcca 577741 tatcgtcggg cctggtgatt ctttgttttc gataggcaga agatacggtg cttctgttga 577801 tcaaatacgg ggtgtgaatg gtttagatga aacgaatatc gtgccggggc aggctctgct 577861 tatccctctt tatgtatata cagtccagcc gagagatacg cttaccgcca ttgcagctaa 577921 agcgtttgtg ccattagagc gactgcgagc ggccaatccg ggcatcagcc caaatgcttt 577981 acaagcggga gcaaaaataa cgattccttc gatctcaaat tacattgcgg gaacgttaag 578041 tttttatgtg ctccgaaacc cagacctcga tcgggaatta atcaatgatt atgcgccata 578101 ctcgtcttcg atttcaattt tcgaatacca tattgcaccg aacggcgaca ttgcaaacca 578161 attgaatgat gcggccgcta ttgagacaac ttggcaaaga cgagtcacgc cgctggcaac 578221 aataacgaac cttacatcag gaggcttcag tacggagatt gttcaccaag tgctaaacaa 578281 tccgacagcg agaaccaatc tggtcaacaa catttatgac ttagtttcca caaggggata 578341 tggcggtgtc acaatcgatt ttgagcaggt gagcgccgcg gatcgcgatc ttttcactgg 578401 atttttacgc cagctgagag atcgacttca ggcgggaggg tatgtgctga cgatagctgt 578461 tcctgcaaaa acaagtgata atatcccatg gctgaggggc tacgattacg gggggatagg 578521 agcggttgtc aattatatgt ttatcatggc ttatgattgg catcatgcgg gaagtgagcc 578581 gggtcctgta gcgccgatta ctgaaataag gagaaccatt gagtttacga ttgcgcaggt 578641 gccgagcaga aaaatcatta tcggagtccc gctctacggg tacgactgga tcatcccgta 578701 ccagccgggc acagttgctt cagcgatttc aaatcaaaac gcaatcgaaa gagcgatgag 578761 gtaccaagcc ccgatacaat attcagccga atatcaatca ccgtttttcc ggtacagtga 578821 tcagcagggg cggacgcatg aggtatggtt tgaggatgtc agaagcatga gccggaagat 578881 gcagatcgtc cgtgaataca gattgcaggc tattggcgct tggcagttaa cgctgggctt 578941 tacgccgggc ccatggcttc tgcggaaatt ttttacgatc agaaaagtgt aaaaaaagac 579001 accagagctt gggtgtcttt tttttgatta agtccagagc agcagaatag ttcattcatt 579061 tgtaccttgc atgggttgtg ttcccatttt acgattagta gtagtctgat caaacaaaga 579121 gtcagaatac gatttgagag ggagttgtct acatgaagac agtattgatt ttgaattttc 579181 ctgcggaagg ccatgtgaat cctactttag gcattacgaa agcgttttcc gataagggat 579241 atgatgtcca ttatatatcc actgaaaaat ataaaaaacg attagaagca gcgggagcaa 579301 cggtccatct tcaccgggat ctgctgcgaa cgacacctat tcatgtcggt tcgcccaatg 579361 gcattcttga tttcgtgaaa atccatatca aaacgtcatt ggacatttta cagattgtca 579421 aagacttatc taagagcatt caatttgatt ttgtttatta tgataaattc ggcgcggggg 579481 aattggtgag ggattactta gatattccag gggtctcttc atcggcgtct ttcctgtttg 579541 gcgaggagca tctgaaaatc ctgccgctgc atccggagtc tggagcgccg cttgaattgg 579601 atcaagagtg cgaagacctt ttggcaaaaa tgaaagaaac gtacggtgtt gccccgaaaa 579661 acctggttca attcatgaac aataaagggg aattgaacgt agtgtataca agccgttatt 579721 ttcagccaga aagtgatcgt ttcggggatg aatgtctatt tatcgggccg agctttccaa 579781 agagagcgga aaaaacagat ttcccgattg aacagctaaa agatgagaag gtcatttata 579841 tttcaatggg gactgtactg gatcatacag aggatttctt caacctttgt attgatgcat 579901 tttcaggctt taacggaaaa gtcgtcatcg ctgccggaga aaaagcggac ctgaccaaat 579961 taaagcaggc gccggaaaac tttatcattg ctccgtatgt ccctcagctg gaagtgctgg 580021 agcaatcgga tgttttcatt acacacggcg gaatgaacag cgtaaacgaa ggcattcatt 580081 tcagcgtgcc actggttgtc atgcctcatg acaaggatca gccgatggtg gcgcagcgtc 580141 tctctgaact ccatgcaggc tatgtcatct ctaaagatga agtcaatgcc caaatattaa 580201 aacaggccgt agatgaggtt ttgcgcaacg atcagtatac ggcaggcatt aaaaaaatca 580261 atcaaagctt caaagaatgt atggacatgg aagaagtgat ggagcggatt gatgagttga 580321 ttcgccaaaa aaacaaataa gaaaaagaac tcccgtacct tgtacgggag ttcttgattt 580381 aaaacttgat tttgattttt tgagcatcac tgattttctt atggttatgg tcaaagacgt 580441 cacttgtcgt gatttcgatc cacttgatct cttttgtttt cttctcagca tccgcggcct 580501 tatcatgagc atggccgctt gatgcgttca caataaagcc gagatttccg gacttttcgg 580561 cgccgccttc caattcgccg tttaactctt caagataaat atctttgttc caatcaaagg 580621 tttcacccgt atttgttttc atcaatgcaa tcggcgcaac atttactttt tttgtagagg 580681 tgttcttgat atcaacgaaa accttaacga aatcaaactc ttcatcgtgt gttaactcat 580741 gaaagtaatc aatcatgctg tagtccgggc gcaagtggat cagcttcatt tcttttactg 580801 ttaactccac gtcgccaatt ttataggttt tgttcacttg tttgatatct tttaagacag 580861 cttttccttt atcatctgaa aacgtttggc cgaccttatg caatgtccgg tcatcagtta 580921 cctgggaatt aggctgataa tcatctgtgc tgtccttctg ggatgaagtg ctttgcggct 580981 cagcttttac tgttttctcc ccgcctgcat gctgtttttc agtactggcg tttgatgagc 581041 agcccgcaag catgatagca aaaacgagaa ttgaaagaat tcttctcatg atgattcctc 581101 cattaaaaag agatcccgtt acttcataca agcaacggga caccttgtat tcttttactt 581161 atcgttaatc ttaatgttgt attgtaaagc cttgaaaaca tttttggcga tttctgtatt 581221 gtcgatttgg ccggcaaatg tctcactaga cggaccgtat gcatagacgg gaacatcttc 581281 accggtatgt ccgcctgttg tccatccagt gtgagagcgt ttattaaaga tgttctcgat 581341 tgcgttatcg atatccagta cttccttcga ttttgccgct tcttcaacag attgaatttc 581401 ggcttttgtt aaagccaatt tcttttgatc gatatatgtt ttcaacgttt tttcaacatc 581461 cgcgccgtca gcgatctttt ctgccataaa gtctggtgtg cgctttgcgg ctttaatggg 581521 ttcactgaac cagttgtaga tgccgtccgc accgatggaa tatccgccgg ttgagtggtc 581581 agccgttgcg acaaccaatg tgtgcttgtc ttttttagcg aaatcaatag ccgccttata 581641 agcttgttcg aagtcttcca tctcgctcat ggcgccaacg atatcattgt catggcccgc 581701 ccagtcaatc tggctgcctt ccaccatgag gaagaatccg tctttatcct tgtttaattt 581761 tttaatggct gtgtttgtca tatctttaag tgatggaata tccttcgtac ggtcaatctt 581821 tttaggcagg ccgccgtcag cgaataggcc gagaacttgg ctgtctttgt ttttcagcat 581881 gtccttgcga tcatccacgt agctgtaccc cgcctttttg aattccttaa tcaaattacg 581941 gtccttacgg tcaaaattgc tctttcctcc gcctagaagg acatcaattt tgtgcttgcc 582001 gttgaccatc tcatcaaaat aatcatccgc aattgagttc atattttttc ggctgtggtc 582061 gtgtgaacca aaagaggccg gagtggcgtg tgtaatttct gaagtggcca caagtcctgt 582121 tgcttttcct ttttctttcg cagcttcaag caccgttttg gcttctgacc cgtcgttatc 582181 aacggctatg gcattattgt atgttttaat tcccgcagac atagccgttg ccgccgctgc 582241 agaatccgtt acattttgtt caggatcatc ggggtaagtt gtttgctggc cgacaagata 582301 ctgatcaaaa gccgtaggct ccacaacttt tgtcttttta ttatccttta agtatcgata 582361 agcagacgta taagacacac ccataccatc accaatcaga acaataacat ttttaatttc 582421 gtcttggttc ccctttttct tttcctgggc gctggcttca ggcacactgc cgctggctaa 582481 gctgctgaac gcaattgatg ataaaaccgc gataggcagt aatttcttcg ggaatttttt 582541 caactggata acctcctaaa tatagatgaa tctcaatgac aacccaatta tatttttaaa 582601 ctgttaagct agtattaatc gattttaaag attggattta caagaataat gaactggcac 582661 ccttaaataa tggttattct tttatgagaa gttttagaag gaaagagcga tagtactaaa 582721 gaaataaatt ggaggaatag atactggccg tggataggcg gactgaaatc tgctatagtc 582781 gcatagaagc aacccgctta catcttgaac aatttaaagt attacgttgg aaagaggtat 582841 tgtgtaagca catgtctgag cagttcatat ggagtggcat cattttattt taggagggaa 582901 caacatggac gttttttctg agtacttagc ggggattgct gacccgttcc accgagaaag 582961 aacggaagag gtgttaactt ggataaaaaa taaatatcca aatttacata cagaaataaa 583021 atggaatcag ccgatgttta cggatcacgg tacatttatt attggcttta gtgtttctaa 583081 aaagcattta gctgtcgctc ctgaaaaagt aacgatagcg cacgtagagg atgatattgt 583141 gaaggccgga tatgattaca ccgagcagct gatacgtatc ccttggaacg gtccagttga 583201 ttatacgcta cttgagaaaa tgattgagtt taatattctg gacaaggcgg actgctccac 583261 tttttggcgg aaatgaagaa aaaggcataa catatgagct gtataaaata tgttacgcct 583321 tttcatttgt ctatttttcg ttttgatcat ctattgctgc ttttcatcaa acaaggtctt 583381 ttcattgagc gtaagctgac tcgcagaata atgattacct tgtttccatt tcacttcaat 583441 cgtaatatca tggccttcaa gctcatgttc atctaaccgc tctaaaaaag aaacggactt 583501 ttcttttgcg cttccatcag aaaaagtgcc tccagcataa tcatgcatcg ggatttccgt 583561 gtcagaactc agcagaactt catcatcctt ttttacaatc agtgattcca gataagtgtt 583621 gtctatttca attgtatcac cgatccaata aagtttgccg ctgtattcat tcggtgcatc 583681 ttcatttttt gtgaaaacag cttcccaatt ctgatctttg ctttctccct gccaatttgg 583741 atactccaaa cgaacatgat gaatcaggtg ataggaaaaa aagatcaagc agaaagcgat 583801 taataggaat gccgtgaaaa tgagagggta tttataatga ctggacataa aagactccta 583861 ttcgtttaat caattacctt cgaaaataga atttcatccc gaatcaaaat gccgttttca 583921 gccacctcgg gaatctccgg cttgagtcgg cgcgcttttt caactgcgtt cggaaacact 583981 gcggcgaatt gatagcctct cttttgataa aacgctatcg catttacatt atcattcgtt 584041 gtgataagct ttattcgttg acaatgtgca tgtttagcct tctcttcaac ctgctgaagt 584101 aaagctgtgc cgattccttt attttcaatc atactatcta atgaaataat ttcacaatct 584161 ttcccatcta ttgtgtatgt aatacagcca atgatttcgc cgctttcatt tactgcggca 584221 aatccatcta attcatcaca ccgaaaaatg ccgctggaaa tcgccatctc gggtgtaccc 584281 caatgcttgg caaaaaaatc ggtcaacata tgtttcgcta tctcattgtt tgggatgatg 584341 atcatcataa cactcctcta ttgaaagatt gcatatgtac tatcaatata aacaatatat 584401 aacaaaaaaa atagatgttg aggtgacggc atggaaatca gcgatatcat ttacgggcag 584461 caccatatag acggagtgct ggaagagctt atcaaaagcg ctcctgtgca aagattaaaa 584521 ggaatctatc aaggcggagc aagcttttta gtcaatcgaa agtggaatgt gaccaggtat 584581 gagcactcca tcggcgtgat gctcctcatc aaaaagctcg gaggaacgat agaagaacag 584641 attgcgggtc tgctccacga cgtatcacac acagcttttt ctcatgtggt cgacgttgtc 584701 tttgaaaatc aagcagaaga ctatcatgaa aacatctttc aacaagtcat tgttcactct 584761 gaaatcccgg acattttaca aaaacacggc tatcatactg aagaactttt atctgacgat 584821 tcaaggtgga cattgctcga acagcccgca ccggagctgt gtgctgatcg gacagactat 584881 acgctgcgtg atatgtaccg atatggacac attaacctgc acgaagcgca aacctttttg 584941 gatcatctta ttgtgagaaa cggaaggatg tttcctgata gtattgaagc cgccgaatgg 585001 tttgtcagtg tgtactacaa ggaagtaatt gatttctttt tgaatcctgt gaatgtatat 585061 ggatatgaat atttagcgcg agcattgaag gcagcgctgc ggcatgatgt catatctgca 585121 gaggatctgc tgaaaacgga ccaagaggta ctgaacatcc tgcgtgcatc aaaaaatgaa 585181 gaagtcctga gcttgcttac atccattcat cccggcatac aagtaataga ggatgacatc 585241 cagtacgatt tccatcaaaa gaagaaaatg cgcctaatcg atccatccat ttttcttgat 585301 gacaaatgga tcaaatcctc aggtgtttct gaaaaggtga ggaaaatggg tgaggccgct 585361 tatcaaaaag caaaaaaagg tgtgtatata aaaatcttaa agcagtaatt gccgcctgac 585421 agcggctttt tttatgtttg gctttgcaaa caaaggggaa taggacaaac tgcgggaacg 585481 ctttatgaga atatcagcgt atttacatac cgttcggggg tatagtatta tcgagagggc 585541 atgttttcat tgtctgcggg caaaagttac aggaaaaaaa tgaagcaaag gagaatgaac 585601 atgaaaatct ctaaatatgc actgggaatt ctgatgttat ctctagtttt tgttttatca 585661 gcatgcggca ataacaacag tacgaaagaa agcacacatg acaatcattc agactcctca 585721 acacatgaag agatggacca ttccggatca gctgacgttc cagagggatt acaggaatct 585781 aaaaatccga aatacaaagt aggcagccaa gtaatcatca atacttctca tatgaaaggc 585841 atgaaaggtg ctgaagctac ggtaacaggc gcctatgata caacggcgta tgttgtttct 585901 tatactccga ctaatggggg acagcgtgtg gatcatcaca aatgggtgat ccaagaagaa 585961 atcaaagatg ccggagataa aacgttacaa cccggagatc aggtgatttt agaggcttct 586021 catatgaaag gcatgaaagg agcaacagcc gagatcgatt ccgcggaaaa aacaactgta 586081 tacatggttg actacacatc gacaacgagc ggcgaaaaag tgaaaaacca caaatgggtc 586141 acagaagatg agctttcagc taaataataa aaaatcctcc ttttacaagg aggatttttt 586201 tgctgtttga acaggtcttg ttaaagaaat gaaagcaaac aggacagcga tgatcacaat 586261 cgatccgccg caccatgccg ttgacaccac agtacccgtc tgatccaaaa caacaccgcc 586321 aatggctgag ccaagggcaa ttccgacttg gagggccgat gtgttaaagc tttgctgaat 586381 gtcagacgaa tcaggtgcaa tttcaattaa atagctttgc tgagccgggg cgaggctcca 586441 gctcagaaga ccccaaatca ccatgacagg caaaaagaaa atcatagacg atgtagacag 586501 cggcagtaag aacataatga tggcaaagga accggtcacc agcaaaatgc tcttaaagga 586561 accaagccgg tcagatagcg ctcctccgaa agggcctccg catacagcag atatcccgaa 586621 aaggaaataa caaatgctga cccagaaaga gctcaggtga agagtctctt ctaaaaacgg 586681 cgcaaagtaa gcgtaaagcg tgtagtggcc agctaatgta aacatcgtga cgaggtgtga 586741 actcgcgatt ttcagattac cgatcgtctt gagttgttcc cggaaaggaa tcattttctc 586801 cgccggtatt ctttcaaaga agattgaaat aatcagcatg gagatcagtg ccaacaggcc 586861 gatgccaagg aacaaaatcc gccacccgaa ggaatcgctg attaagattc cgagcggcac 586921 gcctaatgcg atagcagagc tgaatcccat aaaaataatt ccgattgcgc gggctctgta 586981 ttcaggcgct acaattttcg gggcaattgt taaagaaagc acaacaatca gccctgtact 587041 cattgctgcc aataccctag ataccatcag tgttgcgaaa ttagggctga aataggcgac 587101 aagattgcta aggaagaaaa caaataaagc aattagatat aagcgcttcc gctcaatctt 587161 cgcagtcaat gccaaaagca gcggcccaga tactgcatat cccagcgcaa acacactgat 587221 cagctgtccg gctgaaacaa tggaaatgtc taaatcattt gcgatctgag gaagaattcc 587281 ccccacaatt aactcaacca atccgactgc aatcgtagaa gctgcaagca ggaaaacttt 587341 gaaattcata acaaactcct ttacttaaat gttttgataa ataaaaaaaa tcctgattac 587401 aaaaaatgtc ataaacaaat tttgtaatca ggattttacg gttcctggta gacaccctca 587461 aaccatatta ttgaggttat acaagtgata atagctattt aattgattcg tttccgttga 587521 tgagtgtacc acattatgaa tgaatcttcc atagaaaaat ttataaaacg gtgaaccgga 587581 aaaaaatatg attatattta ttttataaaa gtatagacat ttaaaattaa atgactataa 587641 taatcaatgt aagcgtttta ataacagggg ggatagcagt tgaaaaaaat attactcgcg 587701 tgcagttcag gaatgtctac cagtttattg gtgacaaaaa tgaaggaata cgcacagtct 587761 atcggtgagg aagcggagat ttgggctgtt ggccaggata aagcaaaaga agacatgaga 587821 aaagcggatg ccgttttgat cggtccgcaa atgagctttc tgaaaagcga gctccaaaaa 587881 gaagcagatc aatacaacat tcaagttgaa gtcattgaca tgatggccta cggaatggca 587941 gatgggaaaa aagcgtatga gcaggcattg tccttaatgg tgaatcaata atggaacaga 588001 tgaaaatcac gaatttaaca gacgagcaaa tcagttttca gctaatcctg cacagcggaa 588061 atgcccgcag ctgcatcata caatcactgc gcgcctataa agaagggaaa aaggacgagg 588121 ctgatgccct cattgccaag gcggagcagg atttatccgc ggcccatgac attcactttc 588181 aaatgataca gaaggaatcc ggcggagaag caacagcttt ttcattgctg cttatgcatg 588241 cagaggatca tctgatgtca acattatcca tgaaagaatt agtgaaagag atgcttgatc 588301 tctttaaaac caagaatata taaaaaatcg gggtggatag ggtgttcgag aaaatcagcc 588361 aattccttgt tccaattgca gggaggttaa acaataaccg ctatttgcaa gtgttgcgtg 588421 atgcatttat gctggctttc ccgctgacga tattcgggtc catttttgtc gtgttaacga 588481 atttgccgtt tctaaacaaa atcatgaacg cctcaatgct tacgtcgttt cagtctcatt 588541 tcggcattgc ctccacggcg acaatgggca ttatgtctgt ctttgttgtg ttcgggatag 588601 gctattacct gtcgaaaagc tatcaggtcg aagctgtatt tggcggagcg atcgctttgg 588661 tttccttttt gctcttaacg ccatttatca ttcagccgga aacaggtgat gccattacag 588721 gggttatccc ggtcgatcgt ctcggtgcaa aagggatgtt tcttgggatg attacggcat 588781 ttctttctgg cgaaatttac agaagaatcg ttcaaaaaaa cctgacaatc aaaatgccag 588841 ccggcgttcc gcctgctgta gcaaaatcat tcgccgcact tattccggct tttatcacat 588901 tgactgtatt tttgctgatt aacgtaatgg tgactctgtt ttttaaaaca aatatgcacg 588961 acgtcattta tcatgcgatt caggctccgc ttgtcggact tggaagcggt atcattccaa 589021 cactgattgc cgtgtttttc attcaaattc tttggttttt cggactgcat ggacagatca 589081 ttatcaactc cgtgatggac ccgatttgga atacactgca ggtagaaaac ctttctgctt 589141 acacggcggg aaaagaaatc cctcatatta tttcaaaacc gtttatggag atttatacag 589201 tagggatggg cggaacaggg atgacgcttg cgattgtgtt taccattctc atattcatga 589261 aaagcaggca gatgaagcaa gtatcaaaac ttggcctcgc tcccggtatt tttaacgtaa 589321 acgaaccgat tatctttggg cttccgattg tcatgaatcc gatcattatt gtgccttggg 589381 tgctggcacc gatggttgtt acgctcgtca cctatctggc tatgtcagcc gggctcgttc 589441 cgcctccaac tggtgtgaca gtgccgtgga cggttccatt attcattaat ggcatcatgg 589501 cgacgaactc aatcatgggg ggcgtgatgc agcttatcaa tctgctgatt gtcttcgtga 589561 tctggtttcc gttcctaaaa gcaatggata aattaaatct ggcaaaagaa aaagaacagg 589621 ctgtgcagga gacagctgct cagcaaaatg ataacagcat aaaaatgtga cataagggga 589681 gagagacttg gcacatacag aacaatatcg ttttccaaag gatttttggt ggggatcatc 589741 cgcttcagca acacaaatgg agggtgccgc cgacagagac ggaaaaggcc agaatatatg 589801 ggattattgg tttgaaaaag aaccgcatcg tttttttgat catgtcggac ccgcagacac 589861 atcccaattt tacgacaact ataaagaaga tatcaggctg atgaaggaac ttggccacaa 589921 ctcgttccgg atgtcgattt cctggtcacg tttaatacca aacggaacgg gcgagatcaa 589981 cgataaagcc gcagatttct ataacaatgt cattgatgag ctgatcgcta acggaattga 590041 accttttgtc aatttgtttc atttcgatat gccgatggcg cttcaaaaaa tcggcggctg 590101 ggtcaacaga gagacggttg acgcgtatga aaactatgca agaacttgct tccgtttgtt 590161 tggcggccgg gtgaaaaaat ggttcacgca taatgaacca atcgttcccg tagaaggcgg 590221 atacctatat gattttcatt atccaaacaa ggtcgatttt aaagaggccg tccaggttgg 590281 atttcatacg atgctatcaa gtgcccgcgc cattcaggct tacagggaga tgaagcagga 590341 cggaaaaatc ggcatcatct taaatttgac cccttcatac ccgagaagca gccatccggc 590401 ggatgtgaaa gccggggaaa tcgcagacgc gttttttaac agatcttttt tagacccatc 590461 tgtcaaaggc gaatttccca aagagctggt tgacattttg aagcatgaag gctttatgcc 590521 tgattacaac gctgaagatc tcgacatcat caaaaagaac acggttgacc tgttgggagt 590581 gaattattac cagccgagac gtgtgaaagc gaaagaacat cttccgaatc ccgacgctcc 590641 ttttttgccg gacaggtatt ttgatcccta cgtcatgccg ggccgcaaaa tgaatccgca 590701 tcgcggctgg gagatctatg aaaaaggcgt ttatgatatt ttgatcaatt taaaagaaaa 590761 ctacggcaac atcgagtgtt ttatctctga aaacggtatg ggggttgaag gtgaagagcg 590821 attcagggat gaacaaggca tcattcagga tgattaccgg attgaattta taaaagagca 590881 cctcaaatgg attcaccgcg ccatacagga aggctcgaac gtaaaaggct atcacttatg 590941 gacgttcatg gacaactggt cttggacaaa tgcctataaa aaccgatacg gatttgtatc 591001 agtcaatctt gagaaagacg gagaaagaac cgtcaaaaag agcggaaaat ggttcaaaga 591061 ggttgctgag catagcggtt tctagatttt cctaaaggtc aagatcttcc ggcaatcatc 591121 ataacgaata gagatgacga aaatccgcaa cattgatgaa atagggaaaa gaacttatga 591181 tatccgtaaa agcttatgtg atatcaaaca gctgccggag gataccaatg aataaatacg 591241 aaatcattgc aaatgaaatg agaaatagaa ttaaaaataa cgtatatccg atcgatcagc 591301 ccattcctga tgaagtatct cttgcaaaag aatttaactc aagccgcatg acgatgaaga 591361 gagccttgga taatttagtt gccgagggtc tgctgtttag aaaacgaggc catggcacgt 591421 ttattattca atctgcaata caggatgacc atgtccatgt agtcagcaat gagattctcg 591481 gattgaccaa cttgctgaaa gataaaaaaa tcaaaagcaa ggtcattcag tttgaagtgc 591541 aatttcccac tgaggaagtg gccgcccatt tgtctattga tcagaaaaca ccggtttatt 591601 atgtcgttcg gctgcgaatt gtagaaggtg aaccctatgt attagaaaaa acatatatgc 591661 cgactcattt aataccgggc attaatgacg atgtccttca tgattcgatc tacaatcata 591721 ttacaaatgt gctgcagctc aaaatcgccg gaacgcatcg gaaaatcaga gcctgcaaat 591781 ctgatcatat tgaccagcag catctgggct gtaaacagga tgatccaatt cttgaagtgg 591841 aacatgtggg cttcttagat accgggattc catttgaata ttccttttca cgtcatcggc 591901 atgacaagtt tgttgtgact tctgtaaaca tacggcgctg attgcggaga caacaaggag 591961 gccatctgca tgcttggcgg tattgaagca ggcggcacaa agtttgtttg tgctgtcggt 592021 agagaagatg gaacgatcat tgacaggata gaattcccca caaagatgcc ggatgaaacg 592081 atagagaaag taattcaata ttttagccaa ttttcattac aggcaatcgg catcggctcc 592141 tttggtcccg ttgataacga taaaaccagt caaacatacg gtaccattac ggccacgccg 592201 aaagcgggct ggagacacta tccctttttg caaaccgtta agaacgaaat gaagatccca 592261 gtcggattta gtacagatgt caacgctgcg gcgctgggtg aattcctttt cggtgaagcg 592321 aagggtcttg acagctgcct gtatataacg attggcactg gcatcggagc gggggctatt 592381 gtagagggga ggctccttca ggggctgtca cacccagaga tgggccatat ttatatccgg 592441 aggcacccgg atgacgtata ccaagggaag tgcccttatc atggagattg ctttgaaggc 592501 ttagcttcag gccccgctat cgaagcccgc tgggggaaaa aagccgcgga tttatcagat 592561 atagcacaag tctgggaact ggaagggtac tatattgccc aagcactggc tcagtatatt 592621 ttgatccttg cacctaaaaa aatcattctt ggcggcggcg tcatgcaaca gaaacaagtg 592681 ttttcttata tctatcaata tgtaccaaaa atcatgaaca gctacttaga tttttctgaa 592741 ttatcagatg atataagtga ttatattgta cctccacgtt taggcagtaa cgccggaatc 592801 atcggcacgc tagttttagc gcatcaggcc ttacaagcag aggcagcatc cggggaggtg 592861 cgatcatgac gcatccatta tttttagagc ctgtctttaa agaaagacta tggggaggga 592921 cgaagcttcg tgacgctttt ggctacgcaa taccctcaca aaaaacaggt gagtgctggg 592981 ccgtttctgc acatgcccat ggctcgtcgt ctgtaaaaaa tggcccgctg gcaggaaaga 593041 cacttgatca agtatggaaa gatcatccag agatattcgg gtttccggat ggtaaggtgt 593101 ttccgctgct ggtaaagctg ctggacgcca atatggatct ctccgtgcaa gtccatcctg 593161 atgatgatta tgcaaaactg cacgaaaatg gcgaccttgg taaaacggag tgctggtata 593221 tcattgattg caaagatgac gccgaactaa ttttgggaca tcatgcaagc acaaaggaag 593281 agttcaaaca acgaatagaa agcggtgatt ggaacgggct gctgaggcga atcaaaatca 593341 agccaggaga tttcttttat gtgccaagcg gtacactcca tgctttatgt aagggaaccc 593401 ttgtccttga aatccagcaa aactctgata caacatatcg cgtatacgat tatgaccgct 593461 gtaatgacca gggccaaaaa agaactcttc atatagaaaa agccatggaa gtcataacga 593521 taccgcatat cgataaagtg catacaccgg aagtaaaaga agttggtaac gctgagatca 593581 ttgtttatgt gcaatcagat tatttctcag tgtacaaatg gaagattagc ggccgagctg 593641 cttttccttc atatcaaacc tatttgctgg ggagtgttct gagcggatca ggacgaatca 593701 taaataatgg tattcagtat gaatgcaatg caggctcaca ctttattctg cctgcgcatt 593761 ttggagaatt tacaatagaa ggaacatgtg aattcatgat atctcatcct taatgaatgg 593821 gggagttgca tttgtttaag aaacatacga tctctttgct cattatattt ttacttgcgt 593881 ctgctgtttt agcaaaacca attgaagcgc atactgtgtc gcctgtgaat cctaatgccc 593941 agcagacaac aaaaacagtg atgaactggc ttgcgcacct gccgaaccga acggaaaaca 594001 gagtcctttc cggagcgttc ggaggttaca gccatgacac attttctatg gctgaggctg 594061 atagaatccg aagcgccacc gggcaatcgc ctgctattta tggctgcgat tatgccagag 594121 gatggcttga aacagcaaat attgaagatt caatagatgt aagctgcaac ggcgatttaa 594181 tgtcgtattg gaaaaatggc ggaattccgc aaatcagttt gcacctggcg aaccctgctt 594241 ttcagtcagg gcattttaaa acaccgatta caaatgatca gtataaaaaa atactagatt 594301 cttcaacagt agaaggaaag cggctaaatg ccatgctcag caaaattgct gacggacttc 594361 aagagttgga gaaccaaggt gtgcctgttc tgttcaggcc gctgcatgaa atgaacggcg 594421 aatggttttg gtggggactc acatcatata accaaaagga taatgaaaga atctctctat 594481 ataaacagct ctacaagaaa atctatcatt atatgaccga cacaagagga cttgatcatt 594541 tgatttgggt ttactctccc gacgccaacc gagattttaa aactgatttt tacccgggcg 594601 cgtcttacgt ggatattgtc ggattagatg cgtattttca agatgcctac tcgatcaatg 594661 gatacgatca gctaacagcg cttaataaac catttgcttt tacagaagtc ggcccgcaaa 594721 cagcaaacgg cagcttcgat tacagcctgt tcatcaatgc aataaaacaa aaatatccta 594781 aaaccattta ctttctggca tggaatgatg aatggagcgc agcagtaaac aagggtgctt 594841 cagctttata tcatgacagc tggacactca acaagggaga aatatggaat ggtgattctt 594901 taacgccaat cgttgagtga atccgtaatg tcacaattaa gaaggtgctc aagaagtttc 594961 ttgagcacct tcccactgga ttaagcattc atatcgccta acccaggact gtgttcattt 595021 ggtatttcag gaagcactgg tacgggaaac cctgccggag gatctattac ttgtaactct 595081 ccgccatttc ggcttggaga tttcccttga tagatttcac tgattctcgt ttcatccaac 595141 ctaaagttaa aatgtgtatt atggtagcct aattcgacat actttctgca ctcaggatat 595201 ttattaatgt cataattcgg cacagggagc agcttcgccc attcaacgcc caatgtctcg 595261 agcgctttcg cgaatgcatt ctggtgagca ttgtcgcgta caatcagaaa agcaagtgtt 595321 tcgcggaacg tctgattaga gctcatttca taaattcttg ttttttgcag cacacctgtc 595381 gactcaagaa gcaggttatc cagcaggtca gtaattaagt ttccgtggtt atacacccac 595441 gacccgttcc acggattgcc ccctgcatca acaggaaggg aactttgcgc tccaataata 595501 taatgatgag gattagcatg tttaaccgct tcatcaagtg gcgcttgatc tgtaccttga 595561 ctgccgacac cttcaccgcc tgattcatct aataaagcat tgattgtgtt ttgaaccagt 595621 tcaacgtggg caatctcctc taaaaaaatg ccgcgaagca gatcgcggta ctgtttctgc 595681 tttcctctga aattagagct ttggaaaaaa actgcatcat tgtacgcatt tctccgtaat 595741 gaccgcctaa tatctcctgc aggaccttag cagctgccgg gtctggcttg tccggtttaa 595801 tgatattaat cagttcctct ttgtagtaat acataacacg cctcatttct tcttaagaga 595861 ttttcttata ttatttgtaa gatgagataa aatatataca tgataagcat gggaaggcgt 595921 gaaagaagaa aataaaaaaa tacaggaaaa gtgttgacca aataaaacag gcatggtata 595981 ttattaaacg tcgctgatga acagcgtgaa acaaaacaga aaaacaaaaa agttttccta 596041 aggtgtttac aagattttaa aaatgtgtat aataagaaaa gtcgaattga aaaagattcg 596101 aaaaaacatt aaaaaacttc ttgacttcaa catcaaatga tagtatgata gttaagtcgc 596161 tcaataagcg cccgtagctc aattggatag agcgtttgac tacggatcaa aaggttaggg 596221 gttcgactcc tctcgggcgc gccatataag ataccacgcg ggtgtagttt agtggtaaaa 596281 cctcagcctt ccaagctgat gtcgtgagtt cgattctcat cacccgctcc attattgaat 596341 gatctttgaa aactaaacaa gacaaaacgt acctgttaat tcagtttttg aaaatcgcac 596401 agcgatgtgc gtagtcagtc aaactagggc ctgcacgatg caggtcacac aggtgtcacc 596461 gcgggatgcg gtggacttaa cctgtgatcc atttatcgga gagtttgatc ctggctcagg 596521 acgaacgctg gcggcgtgcc taatacatgc aagtcgagcg aacagatggg agcttgctcc 596581 ctgatgttag cggcggacgg gtgagtaaca cgtgggtaac ctgcctgtaa gactgggata 596641 actccgggaa accggggcta ataccggatg gttgtttgaa ccgcatggtt caaacataaa 596701 aggtggcttc ggctaccact tacagatgga cccgcggcgc attagctagt tggtgaggta 596761 atggctcacc aaggcaacga tgcgtagccg acctgagagg gtgatcggcc acactgggac 596821 tgagacacgg cccagactcc tacgggaggc agcagtaggg aatcttccgc aatggacgaa 596881 agtctgacgg agcaacgccg cgtgagtgat gaaggttttc ggatcgtaaa gctctgttgt 596941 tagggaagaa caagtaccgt tcgaataggg cggtaccttg acggtaccta accagaaagc 597001 cacggctaac tacgtgccag cagccgcggt aatacgtagg tggcaagcgt tgtccggaat 597061 tattgggcgt aaagggctcg caggcggttt cttaagtctg atgtgaaagc ccccggctca 597121 accggggagg gtcattggaa actgggaaac ttgagtgcag aagaggagag tggaattcca 597181 cgtgtagcgg tgaaatgcgt agagatgtgg aggaacacca gtggcgaagg cgactctctg 597241 gtctgtaact gacgctgagg agcgaaagcg tggggagcga acaggattag ataccctggt 597301 agtccacgcc gtaaacgatg agtgctaagt gttagggggt ttccgcccct tagtgctgca 597361 gctaacgcat taagcactcc gcctggggag tacggtcgca agactgaaac tcaaaggaat 597421 tgacgggggc ccgcacaagc ggtggagcat gtggtttaat tcgaagcaac gcgaagaacc 597481 ttaccaggtc ttgacatcct ctgacaatcc tagagatagg acgtcccctt cgggggcaga 597541 gtgacaggtg gtgcatggtt gtcgtcagct cgtgtcgtga gatgttgggt taagtcccgc 597601 aacgagcgca acccttgatc ttagttgcca gcattcagtt gggcactcta aggtgactgc 597661 cggtgacaaa ccggaggaag gtggggatga cgtcaaatca tcatgcccct tatgacctgg 597721 gctacacacg tgctacaatg gacagaacaa agggcagcga aaccgcgagg ttaagccaat 597781 cccacaaatc tgttctcagt tcggatcgca gtctgcaact cgactgcgtg aagctggaat 597841 cgctagtaat cgcggatcag catgccgcgg tgaatacgtt cccgggcctt gtacacaccg 597901 cccgtcacac cacgagagtt tgtaacaccc gaagtcggtg aggtaacctt ttaggagcca 597961 gccgccgaag gtgggacaga tgattggggt gaagtcgtaa caaggtagcc gtatcggaag 598021 gtgcggctgg atcacctcct ttctaaggat attatacgga atataagacc ttgggtctta 598081 taaacagaac gttccctgtc ttgtttagtt ttgaaggatc attccttcga aacgtgttct 598141 ttgaaaacta gataacagta gacatcacat tcaattagta atacaagata tcacatagtg 598201 attcttttta acggttaagt tagaaagggc gcacggtgga tgccttggca ctaggagccg 598261 atgaaggacg ggacgaacac cgatatgctt cggggagctg taagcaagct ttgatccgga 598321 gatttccgaa tggggaaacc caccactcgt aatggagtgg tatccatatc tgaattcata 598381 ggatatgaga aggcagaccc ggggaactga aacatctaag tacccggagg aagagaaagc 598441 aaatgcgatt ccctgagtag cggcgagcga aacgggatta gcccaaacca agaggcttgc 598501 ctcttggggt tgtaggacac tctgtacgga gttacaaagg aacgaggtag atgaagaggt 598561 ctggaaaggc ccgccatagg aggtaacagc cctgtagtca aaacttcgtt ctctcctgag 598621 tggatcctga gtacggcgga acacgtgaaa ttccgtcgga atccgggagg accatctccc 598681 aaggctaaat actccctagt gaccgatagt gaaccagtac cgtgagggaa aggtgaaaag 598741 caccccggaa ggggagtgaa agagatcctg aaaccgtgtg cctacaagta gtcagagccc 598801 gttaacgggt gatggcgtgc cttttgtaga atgaaccggc gagttacgat cccgtgcaag 598861 gttaagcaga agatgcggag ccgcagcgaa agcgagtctg aatagggcgc atgagtacgt 598921 ggtcgtagac ccgaaaccag gtgatctacc catgtccagg gtgaagttca ggtaacactg 598981 aatggaggcc cgaacccacg cacgttgaaa agtgcgggga tgaggtgtgg gtaggggtga 599041 aatgccaatc gaacctggag atagctggtt ctctccgaaa tagctttagg gctagcctca 599101 aggtaagagt cttggaggta gagcactgat tggactaggg gcccctaccg ggttaccgaa 599161 ttcagtcaaa ctccgaatgc caatgactta tccttgggag tcagactgcg agtgataaga 599221 tccgtagtcg aaagggaaac agcccagacc gccagctaag gtcccaaagt atacgttaag 599281 tggaaaagga tgtggagttg cttagacaac caggatgttg gcttagaagc agccaccatt 599341 taaagagtgc gtaatagctc actggtcgag tgactctgcg ccgaaaatgt accggggcta 599401 aacgtatcac cgaagctgcg gactgttctt cgaacagtgg taggagagcg ttctaagggc 599461 tgtgaagcca gaccggaagg actggtggag cgcttagaag tgagaatgcc ggtatgagta 599521 gcgaaagagg ggtgagaatc ccctccaccg aatgcctaag gtttcctgag gaaggctcgt 599581 ccgctcaggg ttagtcggga cctaagccga ggccgaaagg cgtaggcgat ggacaacagg 599641 ttgatattcc tgtaccacct cctcaccatt tgagcaatgg ggggacgcag gaggataggg 599701 taagcgcggt attggatatc cgcgtccaag cagttaggct gggaaatagg caaatccgtt 599761 tcccataagg ctgagctgtg atggcgagcg aaatatagta gcgaagttcc tgattccaca 599821 ctgccaagaa aagcctctag cgaggtgaga ggtgcccgta ccgcaaaccg acacaggtag 599881 gcgaggagag aatcctaagg tgatcgagag aactctcgtt aaggaactcg gcaaaatgac 599941 cccgtaactt cgggagaagg ggtgctctgt tagggtgcaa gcccgagaga gccgcagtga 600001 ataggcccag gcgactgttt agcaaaaaca caggtctctg cgaagccgta aggcgaagta 600061 taggggctga cgcctgcccg gtgctggaag gttaagagga gcgcttagcg taagcgaagg 600121 tgcgaattga agccccagta aacggcggcc gtaactataa cggtcctaag gtagcgaaat 600181 tccttgtcgg gtaagttccg acccgcacga aaggcgcaac gatctgggca ctgtctcaac 600241 gagagactcg gtgaaattat agtacctgtg aagatgcagg ttacccgcga caggacggaa 600301 agaccccgtg gagctttact gcagcctgat attgaatgtt ggtacagctt gtacaggata 600361 ggtaggagcc ttggaaaccg gagcgccagc ttcggtggag gcatcggtgg gatactaccc 600421 tggctgtatt gaccttctaa cccgccgccc ttatcgggcg gggagacagt gtcaggtggg 600481 cagtttgact ggggcggtcg cctcctaaaa ggtaacggag gcgcccaaag gttccctcag 600541 aatggttgga aatcattcgc agagtgtaaa ggcacaaggg agcttgactg cgagacctac 600601 aagtcgagca gggacgaaag tcgggcttag tgatccggtg gttccgcatg gaagggccat 600661 cgctcaacgg ataaaagcta ccccggggat aacaggctta tctcccccaa gagtccacat 600721 cgacggggag gtttggcacc tcgatgtcgg ctcatcgcat cctggggctg tagtcggtcc 600781 caagggttgg gctgttcgcc cattaaagcg gtacgcgagc tgggttcaga acgtcgtgag 600841 acagttcggt ccctatccgt cgcgggcgca ggaaatttga gaggagctgt ccttagtacg 600901 agaggaccgg gatggacgca ccgctggtgt accagttgtt ctgccaaggg catcgctggg 600961 tagctatgtg cggacgggat aagtgctgaa agcatctaag catgaagccc ccctcaagat 601021 gagatttccc attccgcaag gaagtaagat ccctgaaaga tgatcaggtt gataggtctg 601081 aggtggaagt gtggcgacac atggagctga cagatactaa tcgatcgagg acttaaccat 601141 atttttgaat gatgtcacac ctgttatcta gttttgagag aacactctca atttgtttgg 601201 tggcgatagc gaagaggtca cacccgttcc cataccgaac acggaagtta agctcttcag 601261 cgccgatggt agtcgggggt ttccccctgt gagagtagga cgccgccaag cattactttt 601321 atcatcgcgg ggtggagcag ttcggtagct cgtcgggctc ataacccgaa ggtcgcaggt 601381 tcaaatcctg cccccgcaac caaatatatg gttaaataag gagtgcccta agggtgcaac 601441 caaaataatc ctatacaaat atggtccggt agttcagttg gttagaatgc ctgcctgtca 601501 cgcaggaggt cgcgggttcg agtcccgtcc ggaccgccat taatgtaaac gaaacgatca 601561 tgttttcgtt ttttttgtgt tttcttttac tgtatcttct gcttggtgtc atagccaagc 601621 tttctttata tcgggaacat cttggatatt ccagcaaaat tcgataaact aggaagagca 601681 caaataggca taagcagggt tgaaaggagg ttttggttca tggatgaatt tgatttgata 601741 catagcatta ctccgcggac cattcaccat tcttccgttg atgtaggaat aggtgatgat 601801 gcagcgctct acactgcgaa acacggcgtt caggaaattg tttgtgttga tactatggta 601861 gaagacgtgc acttcaaatt acactattcc tcacctgaag atatcgggta caaggcgtta 601921 gccgttaata taagtgatat tgccgcgatg ggaggcattc ctaagtttta tctggtatca 601981 cttgcggtac cttcaaaatg gactgaatct gaaatcaagg cgatgtatga aggaatgaat 602041 gaactggcga aactatatca tatggatctg attggcggcg atacagtttc taccgctgac 602101 aaattagtcg ttacagtcac tgtaatcggt gaaattgaaa agggacaggc ctgtttgcgc 602161 agcttggcaa aaccgaatga tattgtgttt gtaaccggtg aaatcggttc ttctgcagca 602221 gggctttctt tattgctgga agagactaat cctcaaaact catctgtgga aacggattac 602281 tttatccaca ggcataaacg gcctgagcca agagtaagcg tcggcagatt atgctcgatt 602341 tttaaacggg cagctttaaa tgatgttagt gacggattgg ctagtgaact gaacgagatt 602401 gcagaagcca gctgtgtttc aattgaaatt gttgaaagca tgcttccaat tcattctgat 602461 ttgcctaagc ttcatcctaa ctggaaagaa tgggctttgt ttggcggtga ggattttgag 602521 ctgacaggga cggtttcaaa tgaggagtgg gaagtgttga agcaggagtg cgcagcgctt 602581 catcttccca ttacaaagat tggctatgtc agggaaaaaa caaaatctaa agtgatccta 602641 aaaacagatc aaacatcaat gatcttagag aaaaagggat ataatcattt taaataagac 602701 gggtgactcg tgtgaagcaa ttaaaatgga gaactgtaaa tccagaagaa acaaaagcaa 602761 ttgccaagct gacggcagcg tttgctaaac cgggagacgt cctgacatta gagggcgatt 602821 taggtgcagg aaaaacgact tttacgaaag gttttgcaga agggctggga attacacgta 602881 ttgtaaacag tccgactttt acaattataa aagaatataa cgatggcgta cttcctcttt 602941 atcacatgga tgtgtataga atggaagatg aaagtgaaga tttgggactt gatgaatatt 603001 ttcacggaca aggtgtctgt ctcgttgaat gggctcattt aattgaagaa cagctgccac 603061 aggagcgact gcaaattgtc atcaaaagag ctggtgatga tgagcgggaa attaccttta 603121 ctgctgtcgg gaatcggtat gaaatgcttt gtgaggagtt aagtagacat gacaatatta 603181 gcaattgata catcaaatta tacattgggc attgcgctgc ttcgagaaga cactgttata 603241 gcagaataca ttacatattt gaaaaagaac cactctgtaa gagcgatgcc tgctgttcat 603301 tcattgctga atgattgtga tatggcaccg caggaccttt ctaaaattgt cgttgcaaaa 603361 ggccctggtt catacacagg agtaagaata ggtgtgacgt tggccaaaac acttgcctgg 603421 tctttagaca ttccaataag tgctgtatca agtcttgaga cgcttgcggc aaatggccgg 603481 cattttgacg gtctgatcag cccaatcttt gatgctagac ggggacaggt gtacacaggt 603541 ctgtatcaat ataaaaatgg gcttttagag caagttgttc cagatcaaaa tgtgatgctg 603601 gcagattggc tggagatgct aaaagaaaag gaccgccctg ttttgttttt aggccatgat 603661 acttctcttc acaagcagat gatcgaggat gtgcttggaa caaaaggatt cattggaact 603721 gccgcccagc ataacccgcg cccttcagaa ttggcttttc tcgggaagga aaaggaagca 603781 gctgatgttc atgggcttgt cccggattac ttgcggctgg cagaagctga agcgaaatgg 603841 attgaaagtc aaaagtaggg tgataggatg aaaacaaaag cagcggtcag aaatatgcgg 603901 cttgaagata tagatcacgt atacgaaatc gaagcatcct cctttacgtc tccttggacg 603961 aaggattcgt tttatcatga gctgctggaa aatccgtatg ctcattatct cgtgattgaa 604021 aaggacggcc atcttgctgg gtattgcggg atttggattg tgatggacga tgcccagatt 604081 acaaatatag cgataaaacc agagtatcgc ggccagtctt taggagaaac gctttttcgc 604141 tcagctgttg aactgtgcaa agaaaaagac gcaaggcggc tttcgcttga agtgagggtt 604201 tcgaatcatc ctgctcaagg cttatataag aaattcggga tgcagcccgg cggaataaga 604261 aagaactatt atactgataa cggggaagat gcgttaatta tgtgggtgac gataaatgag 604321 tgagcaaaaa gacatgtacg tattaggaat tgaaacaagc tgtgatgaga ctgctgcagc 604381 tattgtgaaa aacgggaaag agatcatttc aaacgtagta gcctctcaaa ttgaaagcca 604441 taagcgcttc ggaggcgttg ttccggaaat tgcttcaaga catcatgttg aacaaatcac 604501 tttggttata gaagaggcgt ttcgcaaagc tggcatgacg tatagtgata ttgatgcgat 604561 tgcagtaaca gaaggtccgg gactggtggg agcgcttctt atcggagtga atgccgctaa 604621 agcattgagc tttgcatata acattccgtt agtaggcgtt catcatatag ccggtcatat 604681 atacgcgaac cgtcttgtag aagacatcgt gttcccggca ctggcattgg tcgtttcagg 604741 aggccataca gaactggttt atatgaagga acatggatca tttgaagtca ttggggaaac 604801 ccttgatgat gcggcaggag aagcctacga caaagtggcg cggacgatgg gattgccata 604861 tccgggtgga ccgcaaattg acaagctagc tgaaaaaggg aatgacaata ttccgcttcc 604921 tcgcgcatgg cttgaagaag gctcttacaa cttcagcttt agcggattga agtctgcggt 604981 gatcaatacg cttcataatg catcccaaaa agggcaagag attgctccgg aagatttgtc 605041 tgccagtttc caaaatagtg tgatcgatgt cttggtaacc aaaacggcgc gcgcggcaaa 605101 ggaatatgat gtcaaacagg tccttttagc cggaggagta gctgcaaaca gaggcctcag 605161 agctgcatta gaaaaggaat ttgcccagca tgaagggatt acgcttgtca ttcctccatt 605221 agctttatgc acggataatg ctgcgatgat tgctgctgct ggtacaattg cttttgaaaa 605281 aggaattcgc ggtgcatatg atatgaatgg ccagcccggc cttgaattga cttcttatca 605341 aagtctcacg agataatagc gtgagacttt ttatctgttt gttattaaca gacaattcac 605401 aatttatcca catatctgtg agtaattata gagatattga tggataaagg gctgaggtca 605461 ctgttaataa agtggataaa ttcagaatat tttgtggata gtgtgtataa agcgcttact 605521 ttgtttattt attaggggat gttctgtgga taaaaagcac ctctaaaaag aggtgcttga 605581 cttttttaat cttcttctgt ggatagttct tcccattcgg acaaaagaga ttccagctcc 605641 tgattaagct tctcattgtc tgcatggata gcttgtactt tttcatgatc ctgatagact 605701 tcagggtcac atagcaattc atcattgcgg ctgatgttct cctcaatggt ttgaacggtg 605761 gtttcaattt cttcaatccg acggagtcgt tggcgctctt tctttttcca ttctttttct 605821 tcctcgtagg aacgtttgga gtcagacttc actgtagctg gcgttttatc agtttcctct 605881 tgctgattca ttttctccaa ttcaagctgc tctgtttttt tctctgtata ataatcgtaa 605941 tctcccagat actcctctat atggcttgaa gaaagctcca atactcttgt ggcgattctg 606001 ttaataaaat atctgtcatg tgagacaaat aacagtgtgc ctggataatc aatcagcgcg 606061 ttttcgagaa cttctttgct gtctaaatcc agatggttcg tcggttcatc aaggatgaga 606121 aagttggctt tttgaagcat cagcttagct agagccaatc ttgctttttc gcctccgctc 606181 agtgaatgaa ctggtttcag cacatcatct ccggagaata agaaatttcc gagacacgtt 606241 ctgatttctt tttctgggag cccggggtac tcgtcccaca gctcatcaag gacacgttta 606301 gaggaagtca actcagcctg ttcctggtca taatagccga cactgacatt tgagccgtaa 606361 gaaattgttc cctgatctgg ttttagggtg tctattaatg ttttcagcaa tgtcgattta 606421 cctattccgt tagggccgac aagcgcagcg ctttctcctc ttgtgagcat gaatgacact 606481 tctgttaaaa gcggcggctg gttttcatag ctgattgtga gatcctgaac acgaaggact 606541 tcatttccgc tctgttttgt aatatcaaaa tgaaagtttg cggatttttc atcgccaagc 606601 ggttttgaca tgacatccat tcgctcaagc tgctttctgc ggctttgcgc ccttttggtg 606661 gtagaggctc tcgccagatt tcgatctacg aagtcctgca gctttgcaat ctcgtcctgc 606721 tgcttttcat acattttcag atctttttca tactgcgcgg ctttttggtc gagataagcg 606781 ctgtagttgc cgtgatactt tttgctttct gctcttgata cctcgtatac ctggtttact 606841 actttgtcca aaaagtagcg gtcatgcgaa acgatgagaa tggcgcctga atagccttgt 606901 aaataatgct caagccaggt aagcgtatca atatccagat ggtttgtcgg ctcatcaaga 606961 atgagcaaat caggctgtgt taatagaagc ttacctaaag ccagtcttgt tttctggcct 607021 ccgctgaggc tttgaacctg tgtagaatcg tcaaaatggc tgaagccgag accatgcagc 607081 acagatctaa catccgcttc atattgataa ccgcctttat ctttgaattc ctgctgaaga 607141 cggtcgtagg ttttcatgat gctttctaat tcacccgggt cagctgccgc cattttttct 607201 tccatagccc gcatttcctt ttccattgct tttaagtggt caaaaacagt cagcagctct 607261 tcttttatgg taagcttaga atccaagcca gtatgctggg cgagatatcc cattgtaata 607321 tctttcggtt taataatttc gcccttttca tacgaaagct ggcctgcgat aattttaagg 607381 agcgtggatt ttccggcgcc atttcttcct acaatggcga tgcgatcacg atttctgact 607441 tccagcttta tattgtttaa aatagtatca gcaccaaatg atttggacag ctgattaact 607501 tgtaagatca tcatattatt tcacctctgc tataataagt taagtgtagc ttatgaacca 607561 gaagtcagca aacaatacat tggccatata agacatagag aagaaaatag tgtatgatct 607621 gtttaaggag cgttttaata tgaatggatt ttctcatttt aatgaacagg gcagagccca 607681 gatggtggat attagcgaaa aatcttcgac tgtccgtact gcggcggctg tttcaagcgt 607741 acacatgaag aatgaagtgt acgagaaaat acaaagtcac gatatcggca aaggagatgt 607801 actggctgtc gcacaggtgg caggcattat ggccgcaaag caaacgtcga atatcattcc 607861 gatgtgccat ccgctttcat tgagcggggt agatatatcg tttgactgga aaataaaaga 607921 agcagaagtt atacttcata taaaagcaca ggtcaaaacg aaagggagta caggtgtgga 607981 aatggaagcg ctcacttctg catcggtgtg cgctcttacc gtttacgata tgtgcaaggc 608041 ccttgataag ggaatggtca tcggccctac tttcttgctg gagaagacag gcgggaaaaa 608101 cggtgacttt aaaagagaac tatccgagta taatttggag gaccaaaaat gaataaggat 608161 caatcaaaaa ttccgcaggc gacggcgaaa cggctgccgc tttactatcg ctttttaaag 608221 aatctgcatg cgtcaggaaa acagcgtgta tcatccgctg aactcagtga tgccgtaaag 608281 gttgattctg ccacgattcg gagggatttt tcctattttg gagctcttgg caaaaaagga 608341 tacggatata atgtggatta tttgctgtct tttttccgga aaacgcttga tcaggatgag 608401 atgacagacg tcatcttgat tggtgtcggg aacttgggaa cggcatttct tcactataat 608461 ttcacaaaaa acaataacac aaaaatttct atggcttttg atataaatga gagtaaaata 608521 ggaactgagg taggcggcgt gcccgtctat aaccttgatg accttgaaca acacgtaaaa 608581 gatgaatcag ttgccattct tacagtgcca gcagttgccg ctcaatccat tacagacaga 608641 ttggtcgcat taggaatcaa gggaatcctt aattttacgc cggcccgttt gaatgtgccg 608701 gaacacattc gaattcatca tatagattta gcagttgagc ttcagtcact ggtttatttt 608761 ttgaagcatt attcagtttt agaggaaatc gaatagaggg aaaggaggag cccaaatatg 608821 ccgatcggtc ctggaagcct tgctgttatc gcaatcgttg ctctgattat cttcggtccc 608881 aaaaagctgc ctgaattggg gaaagcagcg ggagacacac ttcgtgaatt taaaaacgct 608941 actaaaggat taacgagtga tgaagaggaa aaaaagaaag aagatcagta agttaggatg 609001 acacgaatga aagtgaatca aatgtcgctg ctggagcata ttgctgagct tcgaaaacgg 609061 ttgctgattg tagcgctggc gtttgtcgtt ttctttattg ctggattttt tttagcaaag 609121 ccgattattg tgtatctgca agaaacagat gaagcgaagc agcttacgct taacgcgttt 609181 aacctgacag acccgcttta tgtgtttatg caatttgcgt ttatcatcgg catagtcttg 609241 acctcgccgg ttattcttta tcagctttgg gcttttgtga gcccgggcct ctatgagaaa 609301 gagcgcaaag taacgctcag ctacattccg gtctctattt tgctgttttt agcgggctta 609361 tctttttcat attatatttt atttcctttt gttgttgatt ttatgaagcg gatttctcag 609421 gacttgaatg tcaatcaggt gatcggaatt aatgaatatt ttcattttct tctgcagctg 609481 acgattccgt ttggactgct gttccaaatg ccggtcatcc tcatgttttt gacaaggctc 609541 ggaattgtga caccgatgtt cttggcgaaa atcagaaagt atgcgtattt tacgctgctg 609601 gtgatcgcag ccctgattac accgcctgag cttctgtccc atatgatggt cacagtcccg 609661 cttttgattt tatatgaaat cagtatcctt atatcgaagg ccgcttatcg gaaagcacag 609721 aaaagcagtg ctgccgatcg ggacgtgtct tctgggcaat aataaaaaat ccatttctca 609781 tgcgagaaat ggattttctt tatttttggt tctttttgat tttaaatgaa aaggcgaaca 609841 tcttaaaaga aatgctgatg ttgtaagcgg cgaacaccat cagcaggatg gagtaaaatg 609901 accacatgct gcctggcgag cttgcggcaa gataagtaaa gatgcaccct acggcaaagt 609961 agatcattcc ccaaactacc gggtttctca taaaaataat cctccaataa tcaattgcat 610021 ttgtgtgctc tgctgttcaa ggtaattacg aacaggctca agctgcatga tgacgacgaa 610081 tgtattcatc attaaatggg cgaaaatcgg cacccatatc cgttttgttc tcgcatataa 610141 aaaggcaaag gtaaagccca ttgctgtata tagaaggaga tgcttcaaat cagcgtgaac 610201 aataccgaag ataaccgagc tgatcagtcc tgcgaaaaag aaattcgttt tttcgtacag 610261 cgcgccgaaa atgatttttc tgaagatgat ttcttctaat ataggcccga cgatggaaga 610321 aacgataatc atgagcggga ctgcctgaat gacatccaga atcgcttgtg tattttctga 610381 ttctcttccg atgccaaaaa cataatattc aatagagcct gctattcctt gagagaaaag 610441 ggcaatgaaa aaaccggcta tcgcccaaag gatagaaagt ccgattgagt ccttctgtcc 610501 gtttcgcagc gtttctttcg gaacggttct cagaatgagc agaacaacaa cgagacaggc 610561 gataaagctg ataacggacc ataatccttg tgcatgcagc atattttcat ctgtaggctg 610621 tcctccggca taaccgaatt taaataacaa gggaatcgcg attaatgcgg aaaactgcat 610681 gatgatatat gtcaaaataa taaaccaata ctgttttctc aaatggtatg tactcctttg 610741 ttaagtgggt ttcgttcatc tacagctatt gtaacataat cggtacgggg gtgaaaaagc 610801 taacggaaaa gggagcggaa aagaatgatg taagcgtgaa aaatttttta tcttatcact 610861 tgaaattgga agggagattc tttattataa gaattgtgtt agcactcttt agtgctgagt 610921 gctaaaatta catattcata ctattgagga ggttatttca ttgttaaagc cattaggtga 610981 tcgcgttgtc attgaactcg tagaatctga agaaaaaact gccagcggaa ttgtgttgcc 611041 ggattctgca aaagaaaaac cgcaagaagg caaaatcgtg gcagctggtt caggtcgcgt 611101 gttagaaagc ggagagcgcg ttgctttaga agtaaaagag ggcgaccgca ttatcttctc 611161 aaaatacgca ggtactgaag tgaaatacga aggtactgaa tacttaatct tacgtgaaag 611221 cgacatttta gctgttatcg gctaattctt aaataaacaa tacttaaaac atttgaggag 611281 gtcttgtaaa catggcaaaa gaaattaagt ttagtgaaga agctcgccgc gcaatgcttc 611341 gcggtgtcga tgcacttgct gatgctgtta aagtaacttt aggaccaaaa ggacgcaacg 611401 tggttctaga gaaaaaattc ggttctccgt taatcacaaa tgacggtgta acaatcgcta 611461 aagaaatcga gctagaagac gcgtttgaaa acatgggtgc taagcttgtt gctgaagtag 611521 ccagcaaaac aaacgacgtt gccggtgacg gtacaacaac tgcaacagtt cttgcgcaag 611581 caatgatccg tgaaggcctt aaaaacgtaa cagcaggcgc taaccctgta ggcgtgcgta 611641 aagggatgga acaagctgta gcggttgcga tcgaaaactt aaaagaaatt tctaagccaa 611701 tcgaaggcaa agagtctatc gctcaggttg ctgcgatctc tgctgctgat gaggaagtcg 611761 gaagccttat cgctgaagca atggagcgcg taggaaacga cggcgttatc acaatcgaag 611821 agtctaaagg cttcacaact gagcttgaag ttgttgaagg tatgcaattc gaccgcggat 611881 atgcgtctcc ttacatggta actgactctg ataagatgga agcggttctt gacaatcctt 611941 acatcttaat cacagacaaa aaaatcacaa acattcaaga aatccttcct gtgcttgagc 612001 aggttgttca gcaaggcaaa ccattgcttc tgatcgctga ggatgttgaa ggcgaagcac 612061 ttgctacact tgttgtgaac aaacttcgcg gcacattcaa cgcagtggct gttaaagctc 612121 ctggtttcgg tgatcgccgt aaagcaatgc ttgaagacat cgctgtcctt actggcggag 612181 aagtcatcac agaagatctt ggccttgacc tgaaatctac tcaaatcgct caattgggac 612241 gcgcttctaa agttgtcgtt actaaagaaa acacaacaat cgttgaaggc gctggcgaaa 612301 cagacaaaat ttctgcccgt gtgactcaaa tccgcgctca agtggaagaa acaacttctg 612361 aattcgacag agaaaaatta caagagcgtc ttgctaaact tgctggcggc gtagctgtca 612421 tcaaagtcgg cgctgcgact gaaactgagc tgaaagagcg taaacttcgc atcgaagacg 612481 ccttgaactc aactcgcgca gctgttgaag aaggcatcgt atccggtggt ggtacagcgc 612541 ttgtaaacgt atataacaaa gtcgctgcag ttgaagctga aggcgatgct caaacaggta 612601 tcaacatcgt gcttcgcgcg cttgaagagc caatccgtca aatcgcacac aacgctggcc 612661 ttgaaggatc tgtcatcgtt gagcgcctca aaaacgaaga aatcggcgta ggcttcaacg 612721 ctgcaactgg cgaatgggta aacatgatcg aaaaaggtat cgttgaccca acaaaagtta 612781 cacgctcagc tcttcaaaac gctgcgtctg tagctgcaat gttcttaaca acagaagctg 612841 ttgtcgctga caagccagaa gaaaacggtg gcggcgcagg aatgcctgat atgggcggca 612901 tgggcggtat gggtggaatg atgtaataaa gggatattaa cccttataca tcaatgtttt 612961 aaccgtctta aaaaactaga caaagcgtga ataaaaaaag agaaggtctt tcatcagttt 613021 actaaactgt tgggagacct tttctccata ttagcggtca tatgagcata aatgtccatc 613081 gtcgtattta tgtccgaatg accaaattgt tgctggattt ctttaatgcc tactcctgcc 613141 tcaattagta aggaggtatg ggtatgccta aaagagtggg gggtgacatt ctttttatcc 613201 cagctttttt gagcagccgt ttaagtctag tctcaataac ctttcttaat tgcggatgac 613261 catcctcccg ctcaaaaata aatgatgagt cttgataaat caatctattt ttaagcttaa 613321 tttcattttg ataaatttta ttttttttta gtagattgac atcgtttcat caattcgaac 613381 gatatcaaca gatcctgttg ttttaggtgt tagcaattgg tatttttcaa tttgattgtt 613441 aggggtgtat agggtctttg tgacctggct tatcattgaa atctgtccat tttaaagcaa 613501 gaagttcacc aattcttagg tcggtctagg caagtacggt aaagaccaaa tggtccattt 613561 ctagcccgtc agattgagcg agctttagaa aatgtgtcag cacctctttt tccaatgctt 613621 tgttgcttct tgggtaattg aaaatcccca gttgggttca ttttaataat cccttgagtt 613681 ttagcttttc ggaaaatcat acggccgcag gcatgaatac ctcccaaaca attgtgactg 613741 tattgctcgt tcagttctaa cgtgcggtct tcatacattt ttttgtgttt tgctaatcgg 613801 gtattgaccc aatactgcga taaaatgcat cattttcttt tcactggccc gtacactgct 613861 tatttttacc ccactccggt tgtaaatctt aagccaacct tttgcaaatg ttttgaaggg 613921 catatctgac tccttaataa aagtcccgtt gtcgttttgg agttctacgt gacgggctgc 613981 tactggggct tctttctttg ttttaaatct tcctttggat atttctagac gttttttggt 614041 taaagggtca atgcctagta gatatgataa ctccacgtct taccgcattg cttgagtttt 614101 gccatttatt tgtccctaac taattttttt tcatcaaatt ggtctttaag tgagtttaat 614161 aatttttgtt tctctcgact ggtcaataat tgcccttcat atttcaaaag attggataaa 614221 tttgagatgg aatcaatcct gatggatggt accgtagact ttaataagaa acgaaaggcc 614281 aactgcgact tcagttggcc tttcctattt ataataaaga aattgagtga gattgctgac 614341 agaactacgt actactcgtt ttctttagtt gcccttgcta atcgttcaac ctctccccga 614401 atcccaatcg caggctccca cgaatcaatc aaacgaatcg ccttctgatt agattccacc 614461 gctttcgttt tctctccttt acgatacaac agctgcgcca ttccgtagtg atagtagatc 614521 agttcaactt gattggcgtt atgtttgtca tagagcattt gctcaaaggc ttcttccgct 614581 ttttcaaact gatcacattt cacgtaagcg acacccagat tgaaataggc ttctatcgtt 614641 ttttcgccgc cgtatgtgga gctgatttca tttgccgctt cgtataattg aatggcttct 614701 acatgataac ctctcgcaaa gcttaagtca ccgcgaacca atagaactct gtgttgaatg 614761 gtaggggaaa tcggttgatt ttcgatttcg tttaaaattg tctctgcttt ttcctgttgc 614821 ccgtctttta aaaacagcct tgctttgagt gcatgtcccc aaacctttag atcataggca 614881 tcgtgagcgt ctgattgttc aagaatcttc agcccggctt ctatttgctg aagcgctccg 614941 tctaaatcat tgacttccat caatgcccag cctgaggtgt cgattcggaa gtacgcttct 615001 cgtgtgtgtt ggcctaagtg atgggcggcg tcggccgctt tgcgtccgta ttcgattcgc 615061 aggggcaggt tgattctgct tagaaaatgg ctaatgcggg tgatgagttc gattaggatt 615121 tctttttgtt cagtttcact tgcccattgg atgaccttta agatgtttgg ccattcttgt 615181 ttcatttgat ctaagttccg tcccagcagg tagctccaat agatagagtt gggctgttcc 615241 cgctttaaat gggtttcggc ataatcaata taatagtgcg cccagcgatt gcgggcttct 615301 ttttcatatt cgtgctgttc ggacaagtgc tgttctccgt aagcgacaac ggtttggtgc 615361 gctaagtatt gtgtcctgcc ttggcttcgt tccggctgaa tcagcgcata tgaccgcatt 615421 tgttccatag cgtaatgaaa acggcgggcg tctaatccgg ctgctgccgc caggcttttt 615481 tcatcaggcg gcttgctgaa aaagcaaagc gtctgccaga gctttcgcgt atcttcattg 615541 catctatccc aggtgcggcc aaagaggaat tcaaacaatt ccagcagtga gtagcctgct 615601 tttccaagct catgaatcag ctgctgagcg gggatgtcat cgtctgacat ataggcaatg 615661 ctgagtgcca tggctttcgg gtttccggca gtcgctgaaa tgaattcgtt tttcaggtca 615721 gatgatagat gtaacagctg ctccagcttt tcccgtttac gtgggaggtt gcatgtttgt 615781 aagcagtgat gcacttcttg ttgaaaaaat tcgtgggcat ctgtttggtc aagaccgctt 615841 agctgaatgg ctgtcatttc tccgaagctt tcccgataag tttgctttac gttttcccgc 615901 gctgtaagga gaacttttac gccttgcgga aggctggtga taaattcatg aatgtcacgt 615961 tctgcagtat caatgctgtc aacgatcagc aggatcggtt tttctctagt gtaattggct 616021 aacgcattgc ggacgacaaa ccgttttaca ttgattgatt tatcgatttg ttctttgcgt 616081 ccgagctgat aggcgatcgt atttaaaaaa tcgctaaagc ttaatccttt ccaatcagcg 616141 ctgacccaga tgatgctgtt gaatgccggc caaactgaag tatcgtcgac acaggaatag 616201 gcggcttcaa gagcaattgt ggtttttccc atgccggccc agccggtgat taaacagact 616261 ggtgatggag aaagcatcca ttgccgtatc gcttccatat caaagctgcg tccgataaag 616321 cgtccggacc agcgtgaggg taaattatgc gtgatgggct gttctgtaag cgcattcgtt 616381 tcttggccgg gtctgtcatg aaacagccgt tttactacat tttcaatttc gccttcactc 616441 ggagccccga ataatccgtc ttttcgcagt attttcgctt ttttcaaaca ggatgctgcc 616501 catacaggca atgcgggttt gatgactggg atagtggtgg cttccagcaa gtcggtcaac 616561 cactcgatat ccaagtcggt cttttcgaga atgatccaga tcattccgaa cagttttccg 616621 tcgtcgattc ttccgggaat gtagtttgcc cccatctgtc cgatccagct tttgatcgtg 616681 tttggggaga ctcccagctg gagtgcgatt ttatctatgt aagactgtcc tgttttttca 616741 ttctttttcc ttctgacttt ataatcagga tgaagtttta gcgttttgac gccaggtgcc 616801 agcatttgtg caaattgttt tcggttttca agttcagcca taagcctgca cctcctatta 616861 gtactatttt atcaatccag cgttttttgt atatgaaaaa ataaaagtac agtgccgctg 616921 tccttttata cagcaggaaa ggctgttgaa cgtgttaaaa agcagataaa atgggggcag 616981 taacagagaa aacaaaaatg tatgcactta cattttattt tctaaagaaa ggaacttgcc 617041 aaatgactca cacagtacct caaaacatga aagcggctgt tatgcacaac acaagagaga 617101 tcaaaattga aacattgcct gtgcctgata tcaatcatga tgaagtgttg attaaggtga 617161 tggctgtcgg aatttgcgga tctgatctgc attactatac aaatggccga ataggcaact 617221 atgttgtgga aaaaccattt atccttgggc atgaatgtgc gggtgaaatt gccgctgtcg 617281 gatcatctgt cgatcaattc aaggtgggag accgcgtcgc tgtagagccg ggtgttacgt 617341 gcggacgctg tgaggcgtgc aaagaaggac gctataatct ttgcccggat gtacagtttt 617401 tggctacacc gccggtagac ggtgcgtttg tccaatatat taaaatgcgt caggactttg 617461 tttttttaat cccagactca ctttcttatg aagaagctgc tttgatcgag ccgttttctg 617521 tcggtatcca tgcggcggcc agaacgaagc tacagcccgg atcaacgatt gcgattatgg 617581 ggatgggccc tgttgggtta atggctgttg ccgcagctaa agcatttggg gcaggcacaa 617641 tcattgtcac cgacttagag ccgctgcggt tagaagctgc gaaaaaaatg ggagcgactc 617701 acattattaa tatacgtgaa caggatgcac ttgaagagat taaaacgatc acgaatgata 617761 gaggcgttga tgttgcttgg gaaacagcag ggaatccagc ggcattgcaa tccgcactgg 617821 cttctgtgcg ccggggcgga aaattggcga ttgtcggttt gccttcacag aacgagattc 617881 cgctcaacgt gccgtttatt gcggataatg agattgatat ttacgggatc ttccgttatg 617941 ccaatacgta tccaaaggga atcgaatttc ttgcttcagg cattgtggac acgaagcatc 618001 tagtaacgga ccaatattcg ctggagcaga cgcaagatgc gatggagcgg gcgcttcaat 618061 ttaagaatga atgtttaaaa gtgatggtgt atccaaatcg ctgagtgaac agggaggatc 618121 ttcgtattct ccctcttgtt tactggaaat gaaaacggat tcttggggtg ggaaatgatg 618181 attggaacag aaaaagtaac ggcattgaag gcgaagcatc agtcaaaatc cagcaccggc 618241 ctgtcctggt ttgaacgaat cggttatgga ttcggcgata tgtcgtataa tattatcttt 618301 cagtttgtaa acgcatactt attattttat tatacagacg tcggcggcat tcagcctgcg 618361 gtaatcgcaa ctttgtttct tgttgtgcgt gtgctggatg ctatttttga cccgatcatg 618421 ggattgattt tagataaaac gaatacaagg tggggaaaag caaggccata tttgctgtgg 618481 gtggcatttc cttttgcgct attcacattc ttatgtttca cgacgcctca tttcggtgag 618541 accggaaata tggtatatgc gtatgtcact tatattctgc ttgggatgtc ctttagtatg 618601 caaacgatcc cggtgaacag cttaacgggg cggatgacga attcggtgga ggaacgaacg 618661 gttctgacca caacccggat gattttggtg tatatcggca ttcttttatc catttcctgt 618721 gcgacaccgc ttgcaactgc tatcggagga gaggatcagg cgtttggatt tcagatgacg 618781 gcgctcatct atgcggctgt cagcatcgtt ttgaatctat ttagtttctt tactgtacgg 618841 gagcggattc agcctaaaaa gagaaaaaaa caagggatca aaaagacgtt atccgtttta 618901 ttcaaaaaca aacccttgct catgttaatt tcatcatttt tggcttttgc gatcgggttt 618961 aatattaagc tcagcacgat ggtgtattat tttacgtata acgtaaacca taaagagttc 619021 gtgtttatgg gcaccgtttt atttttcggg gcagcgctga tcagcaattt gtttattcct 619081 ttcttttctg agaagtgggg cagaaaacaa gtcatgatta tcacggcagc tctatcgctt 619141 atttcttatg ccggcctgca ttttacgccg tattcttcaa ttccactcat tttcatttgg 619201 cttttcgctt cgggattttt cacaacgcct ttaaatacgc ttgcttgggg aatggttgcg 619261 gattgcgtcg attatgcgga atggaaaacc ggaattcgcg cggatggtgt tgtgatttcg 619321 agcatgagct ttattaataa gctgggtgtt gcgttagccg ggtcattttc ggccatttat 619381 ttaggaatcg ccgggtatgt ggcgaataca gaccagacag ttgcgtcgtt gaatgcgatt 619441 aaaaatatga atgctttgat tccgggattt ttcattttgc tttctattat tcttatcgcc 619501 ttctatcctt taacggaaaa aagatataaa cacatcatct ctgagctgga gcaaaggtct 619561 gcgagataaa tagatgtaaa atttttaata ttcaatgttg tatttatggc aaaaagtaat 619621 atactgagac tgtaatctag actttataaa tgagtgtgat aatatgcgta gtcattctgt 619681 agtttgtatt ggggaattgt tgattgattt cttttgtacc gatgttgacg ttgatttaat 619741 ggaagggcgc caattcctga aaagtgccgg cggggcaccg gcgaatgtgt cggcagcgat 619801 tgccaagctg ggcggagacg ccgctttcag cggaaaagta ggaaaggatc cgtttgggta 619861 ttttctgaag cgaacattgg acgctgtaca tgtcgatacc tctatgctgg tgatggatga 619921 gaaagcgcct acaacgcttg cttttgtttc attaaaacaa aatggagagc gtgactttgt 619981 ttttaataga ggcgcggacg ctttgtttac gctggaggac attgaccagg aaaaactaaa 620041 cgaagcgaaa atccttcatt tcggctctgc gacggcactg ttatcggatc cgttttgctc 620101 agcctattta cggttgatgt cgattgcgaa agacaatgga cagtttattt cgtttgaccc 620161 taactaccgt gaagatttat ggaggggaag agtctcagag tttgtaagtg ttgcgaaaaa 620221 agcgatcgct gtaagtgatt ttgtgaaagt cagtgacgag gaacttgaga ttatcagcgg 620281 tgtgaaggat catgaaaagg gagttgcgat ccttcatgag atcggagcca acattgtcgc 620341 tgtgacactt gggaaaagcg gaacgcttct ttccaatgga aaagaccgtg aaatcattcc 620401 aagcattccg gtgacatcaa ttgactcaac aggggcggga gatgcttttg tcggtgcggc 620461 tttatatcaa ttggcaaaca cggatcagat tcaatctgta gatgctgatt ttgtgaaact 620521 gcgtgagatt gtggcgtttg ccaataaggt cggagctctt gtgtgcacta aaattggagc 620581 gattgatgca ctgccgagtt tggatgagat tggagtttct ttgtaaatca ttgaagatgt 620641 ttcttgaaag tctttggact tttgggggca tcttttttta ttgcttacat ttttgttcag 620701 gtaaaaagtt gtatattttt tgtttgaaat gtcatttttt attaaaaaag tgaaactttt 620761 aacgataata aatagtatat gtaacaaggg ttaccgaatt agctttagga ggaacgatat 620821 aatgagtata attggaagat ttaaagatat tatgtctgcg aatatcaatg ctttattgga 620881 caaggctgaa aatccggaga aaatggtaga tcaatattta agaaatatga atagcgattt 620941 ggctaaggtt aaggcagaaa cagcagctgt tatggctgag gagcagagag caaaaagaga 621001 atatcacgaa tgccaggcgg atatggaaaa gatggaaagc tatgcaatga aggcgctgca 621061 agccgggaat gagagcgatg cgagaaaatt tcttgaaaga aaaacatctt tggagtcaaa 621121 gctttctgag ctgcaggcgg cgaatcaaat tgctgcaacc aatgccgcac agatgagaaa 621181 gatgcatgac aaattggtat ctgacattgg agagctggaa gcacgcaaaa atatgatcaa 621241 ggcgaagtgg gcagtagcga aaacgcaaga aagaatgaac aaactgggcg cttctgtttc 621301 aagtacaagc caatcaatgt ctgcattcgg ccgaatggag gacaaagtaa ataaggcact 621361 tgatcaggcc aatgcaatgg ctgaactgaa cagcgctccg caggatgata tggctgatct 621421 gtctgcaaag tatgacactg gcggttcaag ccaggttgat gatgaacttg cggcgttaaa 621481 agcgaaaatg atgctcgata agtaatacat aggaggccgc agctttcggc tgcggcgtca 621541 ttttatcata aaatgtgaga gggaacggta atgataatat cttataagtg tccgaactgc 621601 ggcagtgata tggcatttga cagtgaaacc ggctcgttat cctgcagcag ctgcggaaga 621661 caggacaata ttgaaagcct tccgaaagaa aacattgcgg cacggttttc tgatgatgaa 621721 gcaaaagaat atcaatgtaa aaactgcggt gccgttttga tcacggaagc tgaaacgaca 621781 gcaacgacgt gcagcttctg cggaggtgct gcaatacttg ccgatcgttt atcaggacat 621841 ttggcgccgg cgaaggtcat tccatttaca atcagcaagc aagaagcgga gcaggcattt 621901 cgaaagtggt gcaaaaaagg ccttctgaca ccaagaggtt tcatgtctgc tgatcgtatc 621961 aaaagcatca ccggcatgta tattccattt tggatgtttg atttaaatag tgaagtacag 622021 gtgagagcaa actgtaccag agtccatcaa tatgaagaag gggattatat ttgcacggaa 622081 acagagcact ttgaagcgtt tcgtgatatc aatctcgatt atttgaaaat ccctgtcgat 622141 gcctctgaaa aaatgaaaga cgaattaatg gacaaattgg agccttattc atacgaagag 622201 ctgaaggact ttcaaacggc atatttggcc ggttatattg cggaaaagta caattatacc 622261 gatgaggagc tttttccgag ggcaaaagag aaaatcagca gttatataga ttcatacatc 622321 cattctactt tttccggata tacgtcagtc aatgtgaggg acaaacatat tcacacgaaa 622381 aacgtgaaca gcttttacgt tttgcttcct gtttggatgg tcagttacga ttatgaaaga 622441 gcggagcata tctttgcgat gaacgggcaa acaggaaagg tcgttggaaa gccgccgatc 622501 agtcgaggaa aagtggctgc atggtttagc ggaatagcag gcgggacatt tcttgcgttg 622561 aagctcgtct cattgatgat gggaggcgga ttttgatgcg tggatttttt gggaaagcga 622621 tctttgttgt gctggctgtt ttcatcatga tgcctttact gggtatcgaa gcggtaagag 622681 cctctgaatt gcagcagcat gtgtacgatc gcgctcatct attgtcaaaa gcggagatcg 622741 gaaaacttga atctctctcg gcaaagctgg gtgcaaagag ggacactgat ttcatcatta 622801 ttacgaccaa aagcacaaac ggtgaagata ttgcagacta taccggcgat ttttatgatc 622861 gttacggaaa aggcagtaca gccattctga cgattgatat gacaaacaga gaagtgttta 622921 tcgcaggctt taaaaaagcc gaacagtatt tggacaacag caggctcaat agcatcagaa 622981 atacgatttc atctgattta tccaatgaaa attattttga agcttttgag acatatattc 623041 agctttccta taaagatatg ggcataaaac cgggagtaaa ccctgacaac atattcttta 623101 catggtggtt tcagctgatt gctgccatcg cagtcggggg aattgcggtt tcaatcatgc 623161 tttatcatgc aggcggcaaa gtaacggtta atggaagtac atatatggat cagcgtacgt 623221 ctgatgtgat tgatcaatac gacacttata ttagaacgac tgtaacaaga gaaagaaaac 623281 catcagataa agacagcggc agcgatggcg gtgttacgaa aggcggcacg tcatacagtg 623341 ggagccgggg cagtttttaa atgtaagaaa tagagaaagg gagaggcgta atgtcgtttt 623401 tcagaaatca attagcgaat gtagtagagt gggaagaatt tagagatgat atgatttttt 623461 ataaatggaa caatcgtgaa atcaaaaaag ggagccgttt aatcattcgt cccggacagg 623521 atgctgtctt tttgaacaat gggcgggttg aaggagtctt tcaagatgat ggcgattatg 623581 atattgaatc agaaattatt ccattccttt caacgttaaa gggctttaag tttggcttta 623641 acagcggcat gcgagctgag gtgctgtttg tcaatacgaa ggaatttacc gtaagatggg 623701 gaacaaaaca ggcgataaat attccggcag cgggaatgcc aggcgggatg cccattcgcg 623761 caaacggcac atttaatttc aaggtgcagg actatatcag cctgattgat aaaatcgctg 623821 gcgtgaaaga tcaatatttt gtagaggata ttaaaacccg tatcatttct attctggatc 623881 agcttctcat gaagtggatc acaagagaag ggaaagatat gtttaatctt caagcaaacg 623941 cttttgatat tgccaaggga attcaagagg acttagatat gcaattaata agcgacggga 624001 tgacggtcac tggttttcaa atcatgagct ttaattatcc tcaagaggtt caagatatga 624061 ttacaaagaa cgcttcctac ggtatggttg gggatgtgaa cagataccag caaatatcaa 624121 tgacggatgg aatggcatcc ggaaagatga gcggaagcgg agcggcttcg gatatggctg 624181 gaatgatgat gggaatgaat atggccaatc agatgatgaa ccaaatgaat cagaatcagc 624241 aggcacagtc atcaggccca cagtcaactg gcagcggaag caaaccgaat ttctgtccaa 624301 actgcggaac aaaaacgggc gaagccaatt tttgtccgaa ttgcggccag aagcttgtat 624361 aagaatcata cagtgaaaag tccggagtga tcagcactcg ggactttttt atttaggaga 624421 ataagcatta cctattgctt gctcctgaac aggccatttt cgagcccccg cttggataat 624481 tcccagcagc aattgacgac gttcctttat tgaattgacg gcaatttgaa atgtttgctt 624541 tgataaagcc ggtatgcctg attgttgaag ctttgagatg tctggttctg gcggcgcttg 624601 ttctgcagga tggatatagg cagtatgaac ggtatccaga tagtttttga tacttgagcg 624661 cgcttctttg atatgaagct gattcggctg atattgttca ggaattccgt atttgaaaat 624721 ggttagagcc tcatccaata cagcaacagc tataatggat gattcctgat gctgcgtgct 624781 gtggtaaaaa tgaaggatgg ggaaggcgtt atgctgagcg gtcagctttc ccagttctga 624841 tgaggcagcg acaagaagaa aatcaatgtc gtgaaaatct ttgccattcc atgcattatg 624901 gacgatttca gttccgtcat gccctagact taatacactt tgggcaaagg agcgtttttg 624961 attaaccgca ctcaagacgg aaatcaaata cgtgacagaa aatgtgatgg taagcagtcc 625021 ttgagctgtt tcaataatcg tgacaagctt ccataggcct ccgttcggag cgaggtcgcc 625081 atttcctaat gtaaacatga catagccgga aaaataaatt cggtctgacc aggaagccgg 625141 ttcttttgat tgagtttcca taagtgagtg agggtcactc gagtaaatca aaacccaccc 625201 gctccaaaat agactgatcc atatcactaa cgtcaggcat aacagcagag gaccagccat 625261 acttagaacc tttgcgtggt caccgctgat tttgcggcag cccttccaca gccaggcaga 625321 caggcatctt gtgatcgggc cggcaccgct ctctaaccat aacgtggtcc ataaaaaatc 625381 aatcatcccc gctgtcaata ataaaaggcc tgcaatgata taaccctcat tcattttggt 625441 tgcctccctt aagtcagcct tcttttattt tcttctctat ttccttttat cctgagtctg 625501 aaacaattga acgaatgttt gattttacag agaaaaatag gtgggagtta cccaacactt 625561 actcattttt caatatgaac agaaaatcac aagatttttg acttgattca cacattttca 625621 tgaagaaaaa cgttcatttt ccccttgaat tggtgatttt ccttttatag agtaaaaaat 625681 tttcagaaat ttatattgac tgaaagcgtt tttataatta tgataatatc agatataaca 625741 aaaatgtcac tataacatca ctacaattga actattaagt gactaataaa taccaaatga 625801 acgaggttat gcacaaagaa atgaccattg ttcttttaac gagaaatgaa atcgcttcca 625861 tagggattga catgctaaga agaagggaag gttatgaggt tattggataa aaacatgaac 625921 aactattttc tgaagcctgc ttacgaaatg tgaggaaggc agcagccctg gaataagttt 625981 ttgacatacg cattttgaaa aagactgggg gaaacagtat gaataaacaa ggaaatcaaa 626041 tgtcattttt acgtacaatt attttagtct ccactttcgg cgggcttctt tttggctatg 626101 ataccggtgt gctcaatgga gctttgccgt atatgggaga gccggatcag cttaatctca 626161 atgccttcac agaaggcctt gtcaccagtt cacttctttt tggagcggca ctgggtgctg 626221 tgtttggcgg caggatgtct gattttaacg gccgccgcaa aaatattttg ttcctcgctg 626281 ttatattttt tatttcaacg attgggtgta cgtttgcacc aaatgttacg gtcatgatta 626341 tttcccgttt tgtgctcggt attgcggttg ggggtgcatc cgtaacggtg cctgcctatt 626401 tagcagagat gtctcctgtg gaaagcaggg gacggatggt gacgcagaac gaattgatga 626461 ttgtatcagg acagcttttg gcctttgttt ttaatgcgat ccttggaaca acaatgggag 626521 acaactccca tgtgtggagg tttatgctgg tcattgcgtc acttccagcc ttgttcctgt 626581 ttttcggcat gatcagaatg cccgagagtc cccgttggct tgtttctaaa ggaagaaaag 626641 aagatgcttt gcgtgtattg aaaaaaatca gggacgaaaa acgggcagca gctgagctgc 626701 aagaaattga attcgctttc aaaaaagaag accagcttga aaaagcgaca tttaaagatc 626761 tttcagtccc atgggtgcgc cgtattgtgt ttattggatt agggattgcg attgtacagc 626821 aaattacagg tgtgaattcg attatgtatt atgggactga aattctaaga aattccggtt 626881 tccaaacgga agccgcttta atcggaaata ttgcgaatgg cgtgatttcg gtattggcaa 626941 cattcgtcgg aatctggctg ctgggaagag tggggcgccg gccgatgctg atgacaggct 627001 tgatcggtac gacaacagca ttattgctaa tcgggatatt ctcacttgta cttgaaggat 627061 caccggcact tccgtatgta gtcctgtcat taacggtcac atttcttgct tttcagcagg 627121 gcgccatttc accagtgact tggctgatgc tatctgaaat tttcccgctt cgccttcgcg 627181 gactgggaat gggtgttacg gtattctgtc tgtggatggt gaattttgca gtcagtttca 627241 cgtttccgat attgctggca gctatcgggc tgtccacaac gttctttatc ttcgttggat 627301 taggaatttg ctctgtcttg tttgtgaaga ggtttttgcc ggaaacgaaa gggctttcgc 627361 ttgagcagct ggaggaaaac ttccgcgctt atgatcacag cggggcaaag aaggattctg 627421 gggctgaagt gattggataa tttaaaaaag aatccgcacc cgagtgcgga ttctttttgg 627481 tttcaaatta gttaggtcta acaaggattt tgacttggct tttctcttta ataagagccc 627541 cgaagccttc ctcgatcaaa tcatctagta cgattttttt cgttacgagt ttgtcggctg 627601 agaaatagcc ttctttcatt aatgacaata cagccgggaa gatgtcgcgg tatccgataa 627661 ttccttttac tgtacgttct ttgattacga tatcgttcgg atggatttca gcaccttttt 627721 cccaaatgct gacgatgacg gtttcaccgg caattgtagt ggactggatg gcttgtcgta 627781 acaccactgg gacaccagtg acttcgaatg ctacgtcaac accgcctcct gtacgttctg 627841 caatctcagc gactacatcg tctgttttag acggatcaac gatgatcgcg ccaagctcct 627901 cagctttttg ctggcgttca ggagaaagct caacagcgta aatatcagtt gcaccggcag 627961 ccttcagcgc ttcaatgaca agaagtccga tcgggccgca gccgaataca gccgctttgt 628021 cgcctgcttt gagtttgctt gagcggacag cgtatagagc aactgcagaa ggttcaacga 628081 gcgcgccttg ttcatatgat aattcatcag gaagtttgaa caaaagctct tcatccacag 628141 agacgtattc agagaaaccg ccgcctccgc cggctaagcc gaggaatccc atttgttcat 628201 caaggttgta ggcgccttgg tggccgtgtg tagcaaaaat cggctcgact acaacgcggt 628261 ctccaacttt ataattttca acgccttctc cgacttcgac aacttcaccg gagaattcat 628321 gccccattgt gacaggtgcc gtttcatttg ttaatgggtg cggtttgtca accggaataa 628381 agatcgggcc gcccagatat tcgtgtaaat cacttccgca gatgccgcac catttgactt 628441 tgatctttac ttttcccggc tccgtttttg gctcttcgat atgttcaata cggatatcct 628501 tttggttatg ccatcttgct gccttcatgg attaccactc ctataacttt tgatgtgagt 628561 aattccgcac cggtcaatat gaactgttca caaaatcgcc atttttaaaa ccaaaaaaga 628621 aatgaaattt ttatataata taatctacgt ttttttgaaa aaaagaaact ttaaagaaaa 628681 aagggtctcg cacactcttt tttctttata tgagagtatc aatcgtttac atagctatga 628741 atttggtttg aacaatacgg taatggttcg ttcatattga atgcgacaac tactctatca 628801 ataattataa ctctaatact gctattataa taggataatc ttccatggtt tattttagca 628861 gaggtaactt ttttgacttt gtaacattac tgtaaggata ttgaaataaa aaatagctgg 628921 ttgatcgtgt ataatcttcc tagatgttaa caaacagggg gacgaaatgt tgaagaaagt 628981 cattttagcc gcttttatct tagtaggaag tactttggga gcttttagtt tttcatcaga 629041 tgccagtgcg aaacatgtga acggaaatat tacttggtat aatggagtcg ggaaaaaagg 629101 ctcttcaggt aagaaacttg gacattggga ttgtgcgacc aaaatcggat ttgatgttcc 629161 tagaaacggg acaaaaatca gagcttatgc aaaagcgaag cctaaaaagg tgattacggt 629221 ttataaaaat gatgttggca gaatgcctaa tgcagtgctg gatgttagcc ctaaagcgtt 629281 taaagcgctt ggatacccat taagcaaagg taaagtagcg gggcattaca gctattaatg 629341 tacatatata atctggaaag caagaagtca cattcttgct ttttctattg gtggagataa 629401 aagatgaaaa aaagaatcat attattatta gcagtgataa tagcggcagc tgccgcgggg 629461 gttgcgtttt atgttgcaaa ggataaaggc catgagaagg ctgctgatgt ttcagtcaat 629521 accgaaagcg gtgatgagct gctggtttca attacagata cggatctgct gacaaagtat 629581 tatgaaaatg acaaggtgat ccatgaggag aagctgacca gctatccggc atttgccttg 629641 gatcaaaaac agcaggtgct ctattatacg ggcaataatg aacagaatga aatgaggctt 629701 tttaaattgg atctgaagtc tcataaaaaa acgatgcttt ataaaggcgc ggagagtgcg 629761 gacagtttat ttttatcaaa ggaccgttca accatctatt tccgcttagg aaaagcggac 629821 gaaagcaatt ttcgaatcgc cgcttttgat ctgaagacga aaaagtataa aaatctttat 629881 cctgccgcta atgatcagga tgacaccgtc agcagcttct tttataacca aaaaaacgat 629941 tcatttgcat tgcttcatta ttctgtagaa gaagactaca agaaaacaga tgaagcaaac 630001 gaaaagggca tcgaccctga accgacaacg attcattttg cggaaggccg ccaaaataaa 630061 tttaatgagc tgaaaagcct gaaccaattt atcagcgata ttgctgtttc tgatgatgat 630121 aaacgtattt tattcacatc atatacgcaa aaaggaacgg agcaaaccgc ttctattcaa 630181 atgctcaatg cggatacgaa aaaatatgaa agcatcatct caaatcaaaa atcatttaag 630241 ctgttaattg acgcacagcc tcagttttct aaggatggga agaacattta ttttcttgcc 630301 gaagccaagg gggctaaaaa gctgaaggac gaaacagggc gtgaagctaa ggtgcggacg 630361 atttattcct atagccttga gaataagacc ttcaaaaaag tatgggaaaa tccgaacggc 630421 atcatcaaca gcttttttgt gattaactaa taaaaaccac tcggcatgag ctgagtggct 630481 tttttaatgg atgaggtgca gggctaatga tccgagccat ttaaagatat gaatcagagg 630541 taccgacaaa aacagaagtt caacatatga gttcattgca acattcagct ttttgaacgc 630601 agctcttttt ttcaagtctt tttgctgctg gtttgagatc acgttatcac tcctcttata 630661 tccatattat accattaaaa cagacaaaaa agccctaaac gtttacagtt ttgggcttct 630721 ttcttcgtat ttggcctctt gcaatgagag gcttttattc tgaaatatag aattttgtct 630781 ccgttcgggg tttgtttgct tgcgggagac tgcatttgtt atagggaaga actagcttgt 630841 tttcgtttgg ctgttgtttt ggagattcac taatgaacgg atgccgtcga ccattttact 630901 tccgcacaaa gggcacaatg gcgtatcact gctggcgaag ttttttcggg tccagccatt 630961 acagtcttct tttgtgcatt cccaagtact cacatcttcc tttggcagcg gttcttgatt 631021 tcgtttgtta tagtaagaca taaagtcact tcttccctca tgtattttac tgcacatttc 631081 ctattgtctc atacttttcc ctaatctcct aattcctttt tctttatgac tttccaataa 631141 ccccatctaa aaaggagagg agtgtgctgt taaaagcatc tggctcttct aaaaacgggc 631201 aatggctgct tttaggaaag gtaacgagtg tcgcgtttgg aatattgctg cgcaagtgtt 631261 ccccagctgc tgtagagaaa aatttcttgt cttccccgaa gcacagcaat gccggcacat 631321 tgatgttttg gagggtgccc cggtaatcag cggccgtttg gttaaataaa atcgtgctag 631381 aaatggcagc cggctgtttg aggatttctg ccagcatcca ttctgtttcg gtctcggcag 631441 gcggttctgc gaacatattc tggatgaagc tttcgtagaa aggcagcggg tcagtttgaa 631501 tggcgtgcat cgctgttttt aagccgtcaa aatcaaatgg accatgttcc cagccctccc 631561 attgatagtc cgaagcggat tgatcgatga tcacagcggc ttgaatgtta tcattcccaa 631621 actgattgag ataatcccat acgacaaaag cacccattga ccagccggca agaacgacat 631681 gatcaagctc cattgcattt agaaattccc ttatgtcacg ggcatattgg gaaatggtgt 631741 ggccgtgaag cactttgtca gattcgccgt gtcctctaag atcaagacga atacattgat 631801 aattggcaga aagcaccgaa aattgtttgt ggaaaaattg tccgctcatc agcaccccat 631861 gtataaacag gatcggcgtc ccgctcccgt gtgtttcata gtaaaggcgt gtctgatctt 631921 ctaatatgat gtatggcatg tttctcctcc tttagtttcc atcatgagta tggctggctg 631981 ctgttgagct gatgatggca gctgtcgcgg ctgcctgctg cgcttgaatg actgtttcga 632041 tagcggtgta tagtcctgat tccatcagca gatttttctc catatgctca ctgagataga 632101 ggctgacagc aattttaaag ttcatttcct tttgccattt aaaagctttt tcctggttta 632161 attcgtcagt gatgcacaaa acggttttga tatctggctc ttccagaaat gtgaggagag 632221 caaggtctgg ataatgataa tcctttgttt ttttgacaga ttcagtgatc gattgatata 632281 tctgtttgca agcggaaaca agcatttcgg gctctttttc actttgcaag gccagaatat 632341 ggctgacctg atgtaagtac tgtccttttt taaagccgtt ggctgccagc agttgatagc 632401 atgtttccgc cttctgtagc gcctgcaaac cttttccgtt ttctccaagc agtacggcaa 632461 gcggaacatt ctgagttgaa gtgaggaaat aatgattttt cttcatctgc tgataaacag 632521 ctagccccat gttcatctgt tctttttggt ttgtcgtttc agatttgccg gtgagcaaga 632581 tcagagcgga aaggtatgtg aacatatccc gcttataccc tagcttcacc atttcattgt 632641 atacatcgat gaaagtctga aatgtttgtt ttgcctcatg ctgaaaatga atgtccagaa 632701 tagatgcaac agtaaagcgg tggtgtgaat tgagtgttga gaagctgccg atgtttgatt 632761 tgatatagct gctcaaatca taaaagcgct gaaaatcaaa ctctctttta ttcacaatat 632821 atgcagaaga aatgagcatt aatatctgat cgtgtgaaac tttccatttt aattttgttt 632881 ttaattcagc ataaatggaa atgtaatgct ttgttttttc atgtagatcg tgtgtgagca 632941 taaaaagcag ctccttttgt tgtttttacg taatacgata aatagggcca aaggtttcat 633001 aaagaaaaaa cttgcctgct agaggcaagt ttgtcgggtt atttatgggg atcagttata 633061 tccatcggtc tcatcatgtc atagtcttca tgctctagaa tatggcaatg ccatacgtat 633121 cgtccgctgt acggaccgaa tgtcgccgcg attctcagga cttcacctgc atgcgcttga 633181 atggtgtctt tccagccctt ttcacttggc ggcggcggga cagccggacc ggtataggac 633241 aattccccgc tttcttgata acgggcgata tcaaacggcc gccggtctaa tacacggaag 633301 gagactagat gcaggtggat cggatgtgtt ccgcgtgtcg ggttgataat ggaccatatt 633361 tcagttgtgc cgacttttgg tgtttctgtg acgggatcgt gccagcgttt gttattaagc 633421 agaaggacgg gtctgccgta ttcgtcctgg gtgcctgcca gttttaacgt tctgatgttt 633481 tgtattcttt catgctgtac cgaagggtat gaggcgaggt acttcggctt tctgctttcg 633541 tctttttgtg ccaatggttt tgtgactctg aattgcatga tattcgcatc tgtttcagga 633601 ttgacgtcac cgccgcagcc cgcgctgttt gccaaaatga tcgattctcc ttcatatgct 633661 gtgaagtcaa tgatgatatc gtaacgttca gcaggcgcaa ggctgaaaga attcagttta 633721 acagatcgcg gcaggagccc tccatctgaa ccaatctgaa taaaatctcc gccattatcg 633781 agtgacaggt tataggttct tgtattggag gcgttgatga cacggaatcg gtatttcctt 633841 ggctcgactt ccaagtatgg ccataccttc ccgttgacga gtatggtttc tccgcaaaaa 633901 gccggaacga ttgaaggatt aggcagtgac ggagaagggt tttccggtgc gctcggataa 633961 aacaaagaac catcctcatt gatcgtgcgg tctgtgataa gaagcggcac atcgtattcg 634021 tctgaaggca gttttaagcg tttttccttt gggtcatgaa tgatatatgc accgacaagt 634081 ccggcataga catttagcct ggtgagcgcc atggcgtgat cgtgatacca caatatagcc 634141 ccgcgctgct ggtttggata atgataaacc tctcttttga aataaggtcc tgtttgttca 634201 aagtctttgg aaaaccaagc ctccggatac ccgtcactat catctggcgt gacgccgccg 634261 tgtaaatgaa caacagtctt tacctcgggc tcttcatgct ggctgtcact gtgatgaatg 634321 gtgtgatcaa tcggaaggaa atgcgtggaa ggaaggttat tcatccattt tacatatacg 634381 ttttcatttc ttttaacctc aatggtcggt cccggaaata agccgttgta gccccacagg 634441 cgggttggag ggagatcgcg atggagctga tgagtgcatt cctccatggt gacttcgtag 634501 tatgtttttt cttttgattg ctgtactggc tttagtgtat ctgggattgg gagagcatcc 634561 acaaattttt caagtgtcat tttcatctgt ccttatctaa attttccaaa ttggtactat 634621 agttaatgac aataaggacg tgatggttac aaaaaatctt cgtgctgcag cccgcccgaa 634681 gaagaaaata acaaaatcct aaacggcagg ccgtttagga tttgatcagc attaaggcag 634741 gatatcgggt tgctgctgtg tgactgggtt ggcagccgct ttctcgctca ccttgcgttt 634801 tctgaacaca aggtaagaaa tcagaacgat tcccgtgatg acgcctgtca gcagcagctc 634861 gtctctcatg gaatcaataa acgccatgga cactaaaatt ccgcaaatgg cgatgatggt 634921 caagtaggtt aggaaaggga agagccacat tttgatcttc aatgcttctg ggtttgtttt 634981 ttcgagtttt ttccgcattt tcagctggga aacggcgatg acaagataga cgagtaaagc 635041 gattgcgcct gatgagttga ctaagaataa aaagacggta tccggtgaaa aatagttcat 635101 tacgaccgcg atataagaga aaaatgtccc ggccacaatg gcttgtacgg gaacgccttt 635161 tttgctcaat ttcataaaac ggcgcggcgc ttcatttctt tctgcaagtg aatacagcat 635221 tctggatgtg gtatacaaac ctgaattcag gcaagagagt acggctgtga ggacgataaa 635281 gttcataatc tgtgcggctg cgggcactcc tatatgctca agtacagcga cgaaagggct 635341 ttctaaaata tttgctgaat tccatggcaa cagcgccacg acaatggcga ttgagcccac 635401 gtaaaagacg atgatgcgcc atacaacgga tctggtggct tttgtcacag attcgatcgg 635461 gttggatgtt tcccctgctg caatggcaac gatttcagtt cccataaaag agaagatgac 635521 aacgacaatg ccgagcaata cggagctgat gccctccggg aaaaatccgc ctttgcctgt 635581 aagattcgaa aaaccgactg gctcactgcc cggtgcaaag ccaaaaataa aggcaaaacc 635641 aacgattaga aaagcaatga tagtcacaac tttaatgagg gagaaccaat attcaaactc 635701 accgaaagac ttaacggagt agacgtttgt cagggtgagc acaatggtca agatcaaact 635761 tgtcagccac agcggaatat catggaacca gtattgaata atgccagcac cggcaatggc 635821 ttcgatcgct atgacgatca cccagaaaaa ccagtacagc cagccgattg taaatcctgc 635881 ccacggtccg atggcgtcgt gagcgtattg agaaaacgat ccgctcgtcg ggtttacggc 635941 agacatctca ccgagcattc tcataataaa aatcaccaat aatccggcta acgcgtaaga 636001 aacaacggca cccggaccgg tcgagtgaat cactgaaccg ctgcctacaa ataggccggc 636061 tccgattaca ccggcaatcg aaatcattgt catatggcgg gtctttaatt ccttttttaa 636121 tcctgattga gactggttca taagttacct ccttttaaaa tgcaatcatt actgaatatt 636181 atgataattg aaactctatc ataaatatac agtttgtcga aaattcgtgt aagaaaatat 636241 accagcttat ttcaaatttg tagtgttttg tttgcgcttt cagcgaatgt gtggaaaaaa 636301 tgtttcgttt tttattcgct gtgtgatttt gcgtaatatt tacaattcga tagaatgcga 636361 gaagcactgg tgtccttggg tttgatggga tttttggcgg agcaaataaa ttggatgaga 636421 gaaaaagtgt tccttcgtca ctatttttct gtggcgggtg aatcatgttt ctgtagaccc 636481 actgcggatc agctttgtaa gataataata ggaaaatgtg agcgagagga ggttttgtat 636541 ggagagatat gatgaactga aaaagggaga atccggagcg ctggtcagca ttgccgcgta 636601 tctagttctt tccgcaatta aactgatcat cggttatctt tttcactcgg aagcacttac 636661 ggcagacggg ttaaataaca caactgacat tattgcttct gttgctgtgc tgattggcct 636721 gcgcatctct caaaagcctc ctgacgaaga tcatccatac ggccactttc gagcggaaac 636781 gattgcatcg cttatcgcat cgtttattat gatggttgtc ggactgcaag tgctgttcag 636841 cgccggagaa tctatttttt ctgctaaaca agagacgcca gatatgattg cggcttggac 636901 ggcagcgggc ggggcagtcc tgatgctgat cgtttaccgg tacaataaaa ggctggccaa 636961 aaaggtgaag agccaggcgc tccttgctgc ggctgctgat aataaatcag acgcattcgt 637021 cagtatcggc acatttatcg gcattgtggc tgctcaattc catcttgctt ggattgatac 637081 ggtcactgcg tttgtgatcg gtctgcttat ttgcaagacc gcatgggata tctttaaaga 637141 gtcatctcac tctttgacag atggattcga cataaaggac atttccgctt ataaacagac 637201 aatcgaaaaa atctccggtg tgagccgttt aaaagacata aaagcaagat acttgggcag 637261 tacggttcat gttgatgtgg tggttgaggt atcggcagat ttaaatatta cggaaagcca 637321 cgatatagcc aatgaaattg agcggagaat gaaggaggag catgcgattg attattcgca 637381 tgttcatatg gagcctttag aacaaaaata atggagcttc ctgtcacagg aagcttcagc 637441 gtgtcgacaa accctcgcat tcgttgtcag gtctgcgctt cggtgctcac gaattagaac 637501 attcgctccg ctcctatgct cgtccttcct agacttcaag ggttttcaat cacgctgaaa 637561 agatgacaaa accctaaaat gaaagccatt ttaggatttt gtcaacaatc tggagcttcc 637621 tgccacagga agcttttttg tgtgttttgg ccagctttat tggtaacaat ttgctagaat 637681 cgttttttta tacagattgc tttttgtggt aaagttaggt tacattatga tgaattttgt 637741 agatgactag gaggaaaata atggcatatc aagaagacct gcatcctttg ctggggaaag 637801 cagttgaaca tattaataga gtaatggttg gaaaacgaga catcgccata ctcagcttag 637861 cagcccttct tgccaaaggg catgtgctgc ttgaggatgt acccggagtc ggaaaaacga 637921 tgatggtccg cgcgctggca aagtcaatcg gcgccgattt caaaagaatc caattcactc 637981 cggatttgct gccatctgat gtaacagggg tatctatcta taatgcgaaa acgatggaat 638041 ttgaatatcg tcccggccca attatgggaa atatcgtgct ggcagatgaa atcaaccgta 638101 cctctccgaa gacacagtcg gctttgctcg aagcgatgga agaggggagc gtcacggtag 638161 atggccatac gatgcagctt gccgatccgt tttttgtgat ggcaacgcaa aacccggtcg 638221 aatatgaagg gacctatcct ttgccggaag ctcagcttga ccgtttttta ttcaaacttc 638281 ggatgggtta tccgtccttt aatgaagagc ttgacgtctt atctcttcag gaaaaaagcc 638341 atccgattga gacgcttgag ccggttattg caaaagaaga cttcatcttt ttacagaggg 638401 aagtgcaaaa tgtccgtgct gatgacagca ttaaggaata tatcgttgaa attgtgcaga 638461 aaacgagaca gcatccttct gttcaattag gcgtcagtcc gcgcggctca atcgccctca 638521 tgaaagcggc acaggcatac gcgctgctgc atcatcgcga ctatgtcata ccggatgata 638581 ttcaatattt agctcctttc acgctgccgc accggatgat gcttcatcct gaggcaaaat 638641 ttgaagggat tcaggcagaa gcgatcgtaa gggagatcat gtcagctgtg aaggtgccgg 638701 ttcaaaggtc ggcggtccgc tgatgaataa gaaatggcaa tggctcgtat atggttggaa 638761 gctgattata ttaactttat tgacggctgc tgttttttct tatgcgatgt ttcagggcgg 638821 ctttgtcagc tggtttttgt tttacgcgtt tctccctttt gtcttgtatg ccgggctgtt 638881 ggccttgtat ccgctccgtt cttttcaggc ttcaaggcaa atggataaaa cacaattgca 638941 tgcgggggac aggctgggcg taacggttac gctgagaaga aagctgccat ttccgctgat 639001 gtatatggtg attgaagatt gcctgccaga aggtatcgag tcattaaatc gagacggagc 639061 cgcggccaaa cggctcgttt ttccttggtt taaacggagc atgacgatgt cgtatgaatt 639121 agctcgggta ccgcgcggag agcatcactt tcattctgtc agggtgcgaa ccggggatgt 639181 tcttggcttg attgaaaaaa cagcattttt tgagctggat gataccttgt ttgtttatcc 639241 attctatcag cgtttttcct atcaggtgaa tgagaggcat caggaagacg gtgtaagcgg 639301 ttcttctcct attcatcagc accattcctc agtcgcagca agtgtgcgga attatcagcc 639361 gggagaccgg tttgctgcgt tagattggaa gacatctgca cggcggagcc agctgatgac 639421 gaaggaattt gagccttctc gcagcaaaaa tctgtttctg ctgatggacc gtttttcctc 639481 agacgcattc gaagaggtcg tttcagtgac agcttcgatt cttcattctg ttttaaaaaa 639541 cggcgcgggt gctggtctgg cttccatcgg gaaggaaaaa aacattttcc ctattcagga 639601 aggggatcag cattttaagc acatgcttcg gcatttagcc atcgctcatt gtgatgcggc 639661 agacccgata agccgatatg cacgggaaga gctgggaaag ccatctgttc gccaagctga 639721 tcaagttgtt gtcacgggac agttaacgga agatatgctg cacctcgcag aaataggagg 639781 cggccgggtt acggtgatac tggcaaaaga gaaagatgct gagctctctc aagctgaaaa 639841 tgtcatgatt gaacgcatga tgaaacgcca aatcagagtt cggatcatga ggggcgggcg 639901 agtttcgcgt gttgtttaga aagagaggtg actggttcac atgccgcacg atgatcacaa 639961 gggaagccgt ttgagcttgc tgttatttta ttttctggct tttttattgc tgtgggagtg 640021 gcttaggccg cttgacagtt ttactgaaac gaaacataca ggctttttta gtgtctttat 640081 cggcttgacg tttctgctga cttttttcag gatgaggtgg tttgtcaccg ttcctttttg 640141 tgtcatattt acattgatct cgatacacat cctgttttat caaggatcta tattcgactt 640201 gagctgggtc agctcttttt tgcaggatgt ctatctgaat atcacgctga ttcaatcagg 640261 gcaatggaat gacatgattc cttcatttcg gaccctgctg ttttttgtgc tgctgtggct 640321 gctggtctat ctcctgcatt attgggtgat ttaccagaga agaattttgt ttttcttttt 640381 gatgacagta gcgtatatta cgattcttga tacctttacg ccatatgatg ccacttttgc 640441 cgtaatccgt atcgtgctga tcggcttctt tatgctgggc cttttatact tggaacgcat 640501 taagctgatg gaaagaatca cactgccaaa aacatctgtc ctgaaatggt ttcttccttt 640561 atctgtattg gttttggctg caacgggatt cggactcgcc gctccaaaat cagagccggc 640621 ttggcctgat ccggtgcctt ttcttaaaaa aatcactcat caagaccgcg tgtctgcagg 640681 ggaaagcaaa atcggatacg ggaatcatga tgaatcactc ggcggcccgt tccagcagga 640741 tgctacacct gtttttacat ggcagggaaa agagcgtacg tatttccgtg tggaaacgaa 640801 ggacacgtat accggaaaag gctggattga aacagacaca ggcatgtcgt atcagcttag 640861 caatggaaaa gttgaaaatc tgtggtttga ccataaggtt gcgacagagc gccgcaccgt 640921 ccgtgtaaaa gtcgataagc actacgggta taaccatctg atgtatccga ttggtgcgga 640981 aaccattcag ccaaagcagg ctgtctcact tgaaatgaac ggcaacacgg agcaaatttc 641041 tccgatcagt gaacaagccg gtgaaatcag aaatatgggg aattatacag taacgtacaa 641101 ttccccggtc tataagctgg atgaactgag aaaggtaaaa gtgagaaaaa acagtgagga 641161 gtacacattc agcgatcgct acatgcagct tccagattca ctgccagagc gggtgagaac 641221 ccttgcgatc aaactgactc aggatcacga caatatgttt gataaggtga aagcggttga 641281 ggactattta gggtcaaatg cgttcacata tgaaacagaa aacgtgacca ttccgaagaa 641341 tgatgaagat tatgtcgatc aatttctctt tgaaacgaaa atgggttatt gtgataactt 641401 ttcttccgcc atggtggtgc tcttgcgctc ggccggcatt ccggcccgct gggtaaaggg 641461 ttatacgtcc ggcgaataca aagaagcagg gaacaaaaat ggcagcattt acgaagtgac 641521 aaataacaat gcccattcct gggtagaggt gtatttcccg gaacagggct gggttacatt 641581 tgagccgact aaagggttta caaatccggc tcaatttaca tcttctgaca caaaagactc 641641 tggcagcgat agcagcagct cgccgaagaa agcaaaagag aaacagaaag aagagaaaaa 641701 acagccgcaa aaagaggaaa aacaaaagga aaagcgggag ccagctgttt ctaaaaagcc 641761 gtccgcttcg catactaatg ccggtgcggg cttgtatgca gcgcttgcgg ttcttgcagt 641821 cctcctggtg gcagctgtat tgctgtatgt tttccgctcg ttatggattc ctgttttcgc 641881 cgtgaggaaa ttgaagcggc gcagtgatca gcacgcgttt tttgaggcat atggcgcgct 641941 gctgaaacaa ctgaagagaa aaggactgcc gaaacgagac agtgaaacgc tgcgtgatta 642001 tgcaaaacga attgatgaaa aatacgacat agaagacatg tcaaagctga cattaagcta 642061 tgaaagggcg ctttacagaa atgaagattc ttcggcgcta tggaatgatt cgagagagtt 642121 atgggaaaat ttaattaaaa gaagatggtc ttgaccgctt atcgacgtgt tgttagaatt 642181 agtgaatatt atcggagtct gggagcgagt tggcctgact ccggcaaacg gccttgccaa 642241 agagggcgga gcgagcttca tatctgtcct cgtttttttc tgtgtcaaaa aacttagagg 642301 agattaggtg acaaccatga caaagttagt gaatgaaatg attcttgtcc ttgatttcgg 642361 cagtcagtat aaccagctga ttacacgccg tatccgtgaa ttcggtgttt acagcgagct 642421 gcatccacat acattgacgg ctgaagaaat taaaaaaatg aatccaaaag gaattatttt 642481 atccggcggt ccaaacagtg tgtatgatga aaactctttc cgctgtgacg agaaaatctt 642541 cgagcttgat attcctgttt tgggaatttg ctacggcatg cagctgatga ctcattacct 642601 tggcggtaaa gttgaagcgg caagccagcg tgaatacgga aaagcaaaca tccgcatcga 642661 aggcacacct gatttgttca gagatcttcc gaatgaacaa gtggtttgga tgagccacgg 642721 cgatttggtt gtagaagttc ctgaaggctt cactgttgac gcgacaagcc atcactgccc 642781 gaactcagca atgagcaaag cggacaaaaa atggtatggc gttcagttcc acccggaagt 642841 gcgccactct gaatacggca atgatcttct gaaaaacttt gtattcggtg tttgcgaatg 642901 cgaaggcgaa tggtcaatgg agaactttat cgaaatcgaa atgcaaaaaa tccgtgaaac 642961 ggtcggagac aaacaggttc tttgcgcgct aagcggcggc gttgattcct ctgttgttgc 643021 tgttttgatt cataaagcga tcggcgacca gctgacttgt atctttgtag accatggtct 643081 tctccgtaaa ggcgaagctg agggtgttat gaaaacattc agcgaaggct ttaacatgaa 643141 tgtgattaaa gtagacgcaa aagatcgatt cttaaacaaa ctaaaaggcg tttctgatcc 643201 tgagcaaaaa cgcaaaatca tcggtaatga attcatttac gtgtttgatg atgaagcgga 643261 caagctcaaa ggcatcgact accttgcaca aggtacgctt tacacagata tcatcgagag 643321 cggtacagca acggcgcaaa cgatcaaatc tcaccacaat gtcggcggac ttcctgaaga 643381 catgcagttt gagctgatcg agccgttaaa tacgctcttc aaagacgaag tgcgcgcgct 643441 tggcacagag ctcggcattc cggatgaaat cgtatggcgt cagccgttcc caggaccggg 643501 actcggaatc cgcgttcttg gcgaagtaac agaagaaaaa cttgaaatcg ttcgtgaatc 643561 agatgcaatc ttgcgtgaag aaattgcaaa tcacggctta gagcgtgata tctggcaata 643621 cttcactgtt cttcctgaca tccgcagcgt tggtgttatg ggtgacgcaa gaacatatga 643681 ttacacaatc ggaatccgcg ccgttacatc aatcgacggc atgacatctg actgggcgcg 643741 tatcccgtgg gatgtgcttg aagtcatttc gacacgtatc gtaaacgaag tgaagcacat 643801 taaccgcgtg gtgtatgata ttacaagtaa gccgcctgcg acgattgagt gggaataaga 643861 atcaattaat ggaaaccatc tttttggcaa ttttgccggg aagatggttt tatttgttta 643921 ttacgaacaa aatccgattt tgcgcgacta ttgttcgctt tttgtattgt tttttcaaaa 643981 tgaacttggt acaatagaca cagaaatcaa ataagatgaa ttcgtataat cgcgggaata 644041 tggctcgcaa gtctctacca agctaccgta aatggcttga ctacgtaaac atttctttcg 644101 tttgatataa ataaaacacg gttatttatt caaactgaaa tccgtctgta gtcaagcgtc 644161 ccaaaatgta ttgggacgtt ttttatttgg cgttttcagg acagaataaa tagcaaagag 644221 tgaagggagt caaatagctt gaaaacgttt tttcagtttg atgagctggg caccagctat 644281 cgcaatgaaa tcattggcgg attaacgact tttttatcta tggcatatat tttgttcgtc 644341 aatccgatta cgcttgcttt ggagagcgtg aaagattttc cggaggcgct gagaattgac 644401 cagggtgcgg tctttacggc gacagcgctg gcgtctgcag caggctgtat cttaatggga 644461 ttaatagcga gatatccgat tgccatcgcg ccgggtatgg ggctgaacgc gttttttgcg 644521 ttttctgttg tccttggtat gggtatttca tggcaggcag ctttgtccgg tgtttttatt 644581 tcaggtctta ttttcgttgc tctttcttta acaggttttc gtgaaaaaat catcaacgcc 644641 attccgcctg agctgaaatt ggcagtcggt gcggggatcg gcctgtttat tacatttgtt 644701 ggattacaag gttcaggaat cattacagcg aatccttcta cgctcgtcac gatcggaaac 644761 attcacagcg gtcctgtgct gttaacgatt ttcggtgtga ttgtcacggt tattttaatg 644821 gtgcttcgcg tgaacgcagg cgtgtttatc gggatgctat taacagcggt agccggcatg 644881 attttcggtt tggttccggt tccgactcaa attatcggca gtgtgccaag ccttgcgccg 644941 actttcggac aagcgtggat tcacctcccg gatattttct ctgtacaaat gctgatcgtt 645001 attttaacat tcttgtttgt cggatttttt gatacagctg gtacacttgt tgctgtggca 645061 acacaagctg gtttaatgaa ggaaaacaaa ttgccgcgtg cgggccgtgc gcttttagct 645121 gattcatctt ctattgtgat cggtgccgtg cttggtacgt ctacaacaac ttcttacgtg 645181 gaatcaagct caggtgtcgc tgcgggtgcc cggtcaggat ttgccgcaat tgtaacaggg 645241 attctctttt tactggctac gtttttctcg ccgctcctat cagtcgttac gtcaaatgta 645301 acagcgccgg cgcttattat tgttggtgca ttgatggtgg cgccgcttgg caaaatcgct 645361 tgggataagt tcgaagtggc cgttcctgct ttccttacca tgatcatgat gccgttaacg 645421 tacagcatcg cgactggtat tgccatcgga tttattttct atccgattac aatggtgtgc 645481 aaaggaaaag caaaagaggt tcatccaatc atgtacgggc tgtttgtcgt atttatcctg 645541 tactttatct tcttaaaata aggaatgaaa aaccagctgc actggcagct ggtttttttg 645601 ttgcaaaaga taaaaccatt tcatacgata taccgtcatg tagatgtgcc gccatgcttt 645661 acttaaatgg aaatgacttg actgttcagg aaggcttcgg taccttatat aagtgtttta 645721 ttttcttgct gaatggtatt ccgccgtatt tttttgatag gagttgctga catgacggaa 645781 gaaagaaaag aaacgtttga agaagaaatt aaccagagtg aaagaataga tgcagatgaa 645841 gaaccgctat cgagaatgtc cagaaaggcg agccggcaaa gcaagcagaa gcaaaaacaa 645901 aagcagaaac cgcgccagga acgcggtgaa tcaactgtta aagacaagct tgcgtctgtt 645961 tgggcagcca tcaacagata ttgcggtttt gcgttctcga ttttaaaatc tccggcgaaa 646021 actgtcgtaa cggatggttt ttctcattat aagtacggtc tgatttcaat gcttatattc 646081 agtatcattt tttcaattgg gaattggttt cagttaaagg caagctggaa tcggccgctc 646141 ggtttcggag aacgccatca tgctttctat gacgggtttt tagttgttct tgtgtatttg 646201 ctgatctttt tcgcggtaat ggtctttgct atatgggctg tctcccgcta tatgatgaag 646261 cagaaggtga cgttcagaga agcggctgcc gtattgggtt cattgcttgt acccgtaatt 646321 gctgtttcaa tcctttggct gatctttgcg atcgtaaata tcccaatgct gacagtactg 646381 tttacggtgc tgatcttgtt ttccatcttt tttatcatcg cgctgtatgt acagcgtgtg 646441 taccaggcgg cacaagatgc accaattgat tatatctatt gtgtatttgc agtagttgcg 646501 atagcgctgc tgtttacggc agtgacttgg ccgtttattt ctgaatatat tacggcgtcg 646561 ttgattccgc tttaatgaaa aaaccggcta atcctagccg gtttttttat gtcacacttt 646621 ttacaaatat atctaaaaaa catagttgat ttgtaggatt aacccgtgta tgatggggaa 646681 aatgctgaaa acgtccagcg caaaaacctt tatgtttaag gaggatgatg gacatggctg 646741 atgtacttcg ccgagcaatt aaccaaaaga agcaattttt aaaaaccaaa ttactgctct 646801 cggaatttta tcaaggaaga ggggaacagc ttgctgacta cacgctgagt gagcttgaga 646861 aagaatacaa gtcccttcag aaaatgaaaa aagagatctg acaatagata taaagaggtg 646921 agtctgctga aaagcgggct tttttgtttt gattttgaaa aggcgagaaa gagggtaaac 646981 tactactgtt caacacataa aagcgtgtcg aaatattttg cttaagctta cgggcgaagc 647041 tgattgtaaa cggctcattt ctctagtaga atatgaatgc tttgtgcaag ctgaagagta 647101 gggggatgaa taaaatgatg caaaccatct tatcaaatgg gatagccatg gttctcataa 647161 ttctcattat taatattgtc tatgtgtcat tttttacgat aagaatgatt ttaacgctga 647221 aaggacagcg ttatttagcg gccggcatca gtacgattga aatactggtt tatgtgacag 647281 gactgagtct ggtgctcgat aacttagacc agattcaaaa tgtgatcgcg tacgcgctcg 647341 gttacggtct tggcgtaatt gtcggcatga aaatagaaga aaaattggcg cttggctata 647401 ttatggtcaa tgtgattacg aaggagctcg atcttgatct tccgaagcag ctccgtgaaa 647461 aaggctacgg cgtgacaaac tgggtggcag gcgggcttga aggcgaccgc acagcccttc 647521 agatcctgac gccgagaaga tatgaactcc agctatatga tacgattaaa acacttgatt 647581 caaaagcctt tattattgcg tacgaaccaa aaacaatcca cggcggcttc tgggtcaaag 647641 cggtgaagaa gaggagaatt aaagaataat ggcaaagccg aagaagaaaa agtttgaagt 647701 gacagagcag caaacgattg atgcggtgct tcagcaaatg aaagaagaag gatatctgcc 647761 tgtaaggcga atggaagagc ctatttttat ggaaaaaaag gaaaatgggt caattcagat 647821 cgttccgtgc gggaaaaaaa tcgtatttga agggaaattg atctaaaaca cgaacattag 647881 tagaatgaat ttttgtatcg ttcgataata tcgttgacat tatccatgtc cgttgttaag 647941 ataaacatga aatcaaaaca cgacctcata taatcttggg aatatggccc ataagtttct 648001 acccggcaac cgtaaattgc cggactatgc aggaaagtga tcgataaaac tgacatggat 648061 atatcgcaga agcgaacgac tgacgataca tgtaccatgc ccggtttgta ttgcttcctc 648121 ataagtgcaa tgcagagcgg gtatttttta ttttctgaaa acaaaagcat tagaaggtgg 648181 ggaacagaat gcagccgcta gtaggaatca tcatgggaag cacttccgat tgggagacaa 648241 tgaaacacgc atgcgacata cttgacgaac tcaatgttcc gtacgaaaaa aaggtcgttt 648301 ccgctcaccg gacgcctgat ttcatgtttg aatatgctga aactgctaga gaaagaggca 648361 tcaaggtgat tattgccggt gccggaggag cggcgcatct gccagggatg acggctgcga 648421 aaacaacact gccagtcatt ggagttccgg ttcagtccaa ggcgctgaac ggaatggatt 648481 cacttctttc catcgtccaa atgcctggag gcgtgcctgt tgcgacaaca tccatcggca 648541 aagcgggtgc tgtgaacgca ggcctgttag cggcgcaaat tttgtcagca tttgacgaag 648601 accttgcccg taagctggat gagagaagag aaaatacaaa acagacagtg ttagaaagca 648661 gtgatcagct tgtctaaaca aatcatctat ccgggagctg taatcggcat tatcggcggc 648721 ggccagcttg ggaaaatgat ggctgtgtcc gccaaacaaa tggggtataa agtcgcggtc 648781 gttgatccgg tgaaagattc gccgtgcggg caggttgcgg atgtcgaaat taccgctcat 648841 tataatgacc gtgaagcgat tcgaaaattg gctgaaatca gcgatatcat cacatatgag 648901 tttgaaaaca tcgactatga tgcgctgcat tggctaaaag atcatgcgta tctcccgcaa 648961 ggaagtgagc tgctgcttat tacccaaaac cgtgaaacag agaaaaaagc aattcaatcc 649021 gcgggctgtg aagtcgcacc gtacagcatc gtcaaaacaa agaatgaatt gaaacaggca 649081 gtacaggagc tcaggcttcc ggcagtgctg aaaacatgcc gcggcgggta cgacggcaaa 649141 ggccaatttg tgataaaaga agaggcgcaa atggagcagg cagccgctct gttagaacac 649201 ggaacttgca ttcttgaaag ctgggtttct tttaaaatgg aactgtcggt gatcgtcgtt 649261 agatcggtaa acggtgaaat ttcaacattt ccgacagctg aaaacattca ccacaacaat 649321 attcttttcc aaagcatcgt gcccgcacgg gtagagaaag ggattcagca gaaggctgct 649381 gatctcgcag ttaagcttgc agatgagctt aaccttgtcg gaccgcttgc tgttgagatg 649441 ttcctgacag aggacggaga gcttttggtc aatgaactgg cgccaagacc gcacaattca 649501 gggcattata cgctggacct ttgcgagacg agccagtttg agcagcatat cagagcggta 649561 tgcgggcttc cgcttgggaa gacagatttg ctgaagccgg gcatgatggt gaatcttctc 649621 ggcgatgaag tgaagcttgt tgaggaagac ccggagcttt taaaagaggc aaagctatat 649681 atatacggaa aacatgaaat caaaaaaggc cgcaaaatgg ggcatattac atttatgaag 649741 cagcctgaag acgaatggat tcaggagatc acaaataaat ggatgaatag agacggagga 649801 caagcagaat gatcgaacgt tattcaagac ctgaaatgtc cgcgatttgg acggatgaaa 649861 acagatttca agcatggtta gaggttgaaa ttcttgcctg tgaagcgtgg gcggagcttg 649921 gcgtcattcc gaaagaagat gtaaaggtta tgcgcgaaaa cgcgtcattt gacatcaacc 649981 gcattttaga aatcgaaaag gacacgcgcc atgacgttgt cgcttttacg cgcgctgtat 650041 ccgaatcact gggcgaagaa agaaaatggg tgcattacgg cttaacgtca actgacgttg 650101 ttgatacggc tctttcctac ttattaaaac aggcaaacga tattttgctc aaggatcttg 650161 agagatttgt tgacattata aaagaaaaag cgaaagaaca taaatacaca gtcatgatgg 650221 ggcgcacaca cggcgtacac gctgagccta caacattcgg cttaaaactt gcgctttggc 650281 atgaagaaat gaaacgtaat cttgagcgct tcaaacaagc gaaagcaggc atcgaggttg 650341 gaaagatttc cggtgctgtc ggcacatatg cgaacattga tccatttgtt gaacaatatg 650401 tctgtgagaa gctcggattg aaagcagcac cgatttccac tcaaaccctt cagcgtgacc 650461 gccatgctga ctatatggca acacttgctt tgatcgcgac aagcatcgag aaattcgctg 650521 tggaaatccg cggactgcaa aagagtgaaa cacgtgaagt agaggaattt ttcgcgaaag 650581 ggcaaaaggg ttcatctgca atgccgcata aacgaaatcc gattggctct gaaaacatga 650641 caggcatggc gcgcgtgatc cgcggctaca tgatgacagc ttacgaaaat gttccattat 650701 ggcatgagcg cgatatttct cattcttcag cagaacgaat tattcttccg gatgcgacaa 650761 ttgcgctgaa ctacatgctg aaccgcttct ccaacatcgt gaagaactta acggtcttcc 650821 cggaaaacat gaagcgcaac atggaccgca ctctcggcct tatctattct cagcgtgtgc 650881 tccttgcttt gattgacaca ggcctgactc gtgaagaagc ctatgataca gttcagccga 650941 aagcaatgga agcgtgggaa aaacaagtgc cgttccgcga gcttgtggaa gcggaagaga 651001 aaatcacgtc acgtctttct ccagaaaaaa ttgctgactg ctttgattac aattaccatc 651061 tgaaaaatgt tgatctgatc tttgaacgtt taggtttagc atagaagaag cttttagcgg 651121 cttcttctaa gccgccgcag tttgaaaatt cccaacattc gggttaggag gccttccgtg 651181 aatattgtga agaatgaact tttatacgaa ggaaaagcaa aaaagatcta caaaaccgat 651241 gacgaaaaca cgctgtatgt cgtgtataaa gactccgcca ctgcctttaa cggcgagaaa 651301 aaagcagaaa tcagcggaaa agggcgctta aataatgaaa tttcaagcct cattttcaaa 651361 caccttcatg ctaagggcat taacaatcat tttatcgagc gcatttcgga aacggagcag 651421 ctcattaaaa aggtaacgat tgtgccgctt gaagtcgtgg taagaaatgt tgtggcagga 651481 agcatgtcca aacgtctcgg cattccagaa ggcacggagc ttgagcagcc gattatcgag 651541 ttttactaca aggatgacgc gctgggtgat ccgctcatca cagaagatca tatttggctt 651601 ttgaaggcgg cgactcctga gcaggtagaa accattaagt ccattacaac aatagtaaat 651661 gaagagcttc aaagcatctt cgacgattgt catgtcagat taatagattt caagcttgaa 651721 ttcggtttag atgcagaagg gcaagtgctt ttggcggatg aaatatctcc tgacacatgc 651781 cgcttgtggg ataaagaaac gaacgaaaag ctggacaaag atttattcag acgcaatctg 651841 ggaagcttaa ccgacgcata cgaagagatt ttcaatagac tgggaggcat tcatcatgta 651901 taaagtaaaa gtttatgtca gcttaaaaga aagtgtacta gatccacaag ggagcgctgt 651961 ccagcatgcc ttgcacagta tgacttacaa cgaagttcaa gatgtgcgca tcgggaaata 652021 catggagctt accattgaaa aatctgaccg tgatcttgac gtgctagtga aagaaatgtg 652081 cgaaaaactt cttgcgaaca cagtgattga agattataga tatgaggttg aggaggtagt 652141 cgcacagtga aatttgcggt gattgtgtta cccggctcca actgtgatat cgatatgtat 652201 catgctgtaa aggatgagct cggccatgaa gtggaatacg tctggcatga ggaaacaagc 652261 cttgacggct tcgacggcgt gttaattccg ggaggatttt cttacggcga ttacttaaga 652321 tgcggcgcca tcgcccgatt tgcgaatatt atgccagctg tcaaacaagc agcggctgaa 652381 ggaaaacctg ttcttggcgt ctgtaacgga ttccagattt tacaggagct tgggctgctg 652441 ccaggcgcaa tgagacgcaa caaagatctg aagttcattt gccgtccggt tgaattgatt 652501 gttcagaacg acgaaacctt attcacagct tcctacgaaa agggagaatc gattacaatc 652561 ccggttgccc atggtgaagg gaatttctac tgtgatgacg agacgcttgc tacattaaag 652621 gaaaacaatc aaattgcttt cacatacggc tctaatatta atggaagtgt cagcgacatt 652681 gccggtgtcg tgaatgagaa aggcaatgta ttaggcatga tgcctcaccc tgagcgcgcg 652741 gtcgatgaac tgcttggaag cgccgacggt cttaaattgt tccagtctat cgtgaaaaat 652801 tggagggaaa ctcatgtcac tactgcttga accaagtaaa gaacaaataa aagaagagaa 652861 actgtatcag caaatgggtg tcagtgatga tgagtttgca ttgatagaat ccattcttgg 652921 aagattgccg aactacacag aaatcggaat tttttctgtc atgtggtctg agcattgcag 652981 ctataaaaac tcaaagccga ttctgcgtaa attcccgaca agcggcgagc gtgtgctgca 653041 ggggccgggg gaaggcgccg gaatcgttga tatcggtgat aaccaagcgg ttgtgttcaa 653101 aattgaatca cataaccacc catcagctct cgagccttac caaggcgctg cgactggcgt 653161 aggcggaatt atccgtgatg tattctcaat gggtgcacgc ccaatcgctg tattgaactc 653221 tcttcgattt ggtgaactga cttcaccccg cgtgaagtac ttgtttgaag aagtagtagc 653281 gggtatcgcc ggatacggca actgtatcgg catcccgaca gtcggcggag aagtgcagtt 653341 tgacagcagc tatgaaggaa atccgctcgt caacgcaatg tgcgtcggtt taatcaacca 653401 tgaagacatc aaaaaaggcc aggcaaaggg tgtcggcaac acagtaatgt acgtaggagc 653461 gaaaacaggg cgtgacggca tccacggcgc tacgtttgct tctgaagaaa tgtcagactc 653521 gtctgaagaa aagcgttctg ctgtccaagt cggcgatccg tttatggaga agcttttgct 653581 tgaagcatgt ctggaagtca tccaatgcga cgccttagtc ggcattcagg atatgggagc 653641 tgccggttta acaagctcaa gtgcagaaat ggcaagtaaa gccggttctg gcattgaaat 653701 gaatcttgac ctgattcctc agcgcgaaac aggcatgacc gcgtatgaaa tgatgctttc 653761 tgaatcacaa gaacggatgc ttttggttat tgagcgcgga cgtgagcagg aaatcatcga 653821 tatttttgac aagtatgatc ttgaagcggt ttctgtcgga catgtgacag atgataaaat 653881 gcttcgcctg acacataaag gagaggttgt gtgcgagctg cctgttgatg ccttggcaga 653941 agaagcaccg gtttaccata agccttctca agagcctgct tactatcgcg agtttttgga 654001 aacagacgtt ccggctccgc aaattgaaga tgcgaatgaa atgctgaagg cccttcttca 654061 gcagccgacg attgcgagta aagagtgggt ttatgatcag tatgactaca tggtgcgcac 654121 gaatacagtt gtcgctcctg ggtctgatgc tggtgttctc agaatccgcg gaacgaaaaa 654181 ggcgctggcg atgacgacag actgtaacgc gcgttatctc tatcttgatc ctgaagtcgg 654241 agggaaaatt gctgtcgctg aagcagcgcg caacatcatt tgctcaggcg cagaaccgct 654301 tgcggtgaca gataacctta acttcggaaa ccctgagaag ccggaaatct tctggcagat 654361 cgaaaaagcg gcagacggca taagcgaagc gtgcaatgtt ctcagcactc cggttatcgg 654421 cggtaacgta tcgctttata acgaatcaaa cggcacggcg atctatccga caccagttat 654481 cggcatggtc ggcctaattg aagatacagc gcacattaca acacagcatt tcaaacaagc 654541 aggagatctc gtatacgtga tcggcgaaac aaaaccagag tttgccggaa gcgagctgca 654601 aaaaatgaca gaaggccgta tttacggcaa agcgccgcaa atcgatcttg atgtagagct 654661 gtctcgtcaa aaagcactgc ttgacgcgat taaaaaaggc ttcgttcaat ctgcgcatga 654721 tgtgtctgaa ggcggcttag gcgtagcgat tgcggaaagt gtcatgacga cggaaaacct 654781 tggcgctaat gtgactgtag aaggggaagc ggcgttatta ttctctgaat ctcaatctcg 654841 cttcgtcgtt tcagtgaaaa aagaacatca agctgcgttt gaagcaactg tcaaagatgc 654901 agttcatatt ggtgaggtaa cagctgacgg aattctggcg attcaaaacc aagacggaca 654961 acaaatgatt catgcgcaaa cgaaagagct tgaacgcgta tggaaaggag ctatcccatg 655021 cttgctgaaa tcaaaggctt aaatgaagaa tgcggcgttt ttgggatttg gggacatgaa 655081 gaagccccgc aaatcacgta ttacggtctc cacagccttc agcaccgagg acaggagggt 655141 gctggcatcg tagcgactga cggtgaaaag ctgacggctc acaaaggcca aggtctgatc 655201 actgaagtat ttcaaaacgg cgaactcagc aaagtaaagg gaaaaggcgc tatcgggcac 655261 gttcggtacg caacggctgg aggcggcgga tacgaaaatg ttcagccgct cctcttccgt 655321 tcccaaaaca acggcagcct ggcgcttgct cataacggaa atcttgtcaa cgccactcag 655381 ctgaagcagc agctcgaaaa tcaagggagc atctttcaaa cctcttcgga tacagaggtt 655441 ttggctcacc tgatcaaaag aagcggacac ttcacgctga aggatcaaat taaaaactcg 655501 ctttctatgc tgaaaggcgc ctacgcgttc ctgatcatga ccgaaacaga aatgattgtc 655561 gcacttgatc caaacgggct gagaccgcta tccatcggca tgatgggcga cgcttatgtg 655621 gtcgcatcag aaacatgcgc atttgacgtc gtcggcgcaa cgtaccttcg cgaggtagag 655681 ccgggagaaa tgctgatcat taatgatgaa ggcatgaaat cagagcgttt ttccatgaat 655741 atcaatcgtt ccatttgcag catggagtac atttatttct ccagaccaga cagcaatatt 655801 gacggtatta atgtgcacag tgcccgtaaa aaccttggga aaatgctggc tcaggaatcc 655861 gcagttgaag ctgacgtcgt aaccggggtt ccggattcca gtatttcagc ggcgatcggc 655921 tatgcagagg caacaggcat tccgtatgag cttggcttaa tcaaaaaccg ttatgttggc 655981 agaacgttta ttcagccgtc ccaggctctg cgtgagcaag gcgtcagaat gaagctgtct 656041 gcggtgcgcg gggttgtaga aggcaaacgc gtcgtgatgg tggatgactc tatcgtgcga 656101 ggaacaacta gccgccggat tgtcacgatg ctaagagaag cgggtgcgac agaggtgcat 656161 gtgaaaatca gttcaccgcc gatcgctcat ccgtgctttt acggcattga cacttccaca 656221 catgaagaac tgatcgcgtc ttcgcattct gttgaagaaa tccgtcagga aatcggagcc 656281 gataccctct catttttgag tgtggaaggg ctgctgaaag gcatcggcag aaaatacgat 656341 gactcgaatt gcggacagtg tctcgcttgc tttacaggaa aatatccgac tgaaatttac 656401 caggatacag tgcttcctca cgtaaaagaa gcagtattaa ccaaataaaa cttgaaaaat 656461 gacataaagg cagcgcagtt cggctgcctt tctctttctg ccctcgttcg gggagatatt 656521 ttgaaaagcg ccttaaagga gtgaatagga tgtctgaagc atataaaaac gcaggagttg 656581 acatcgaagc cggatatgaa gctgtaaaac gaatgaaaaa acacgtggag cgcacgaaac 656641 ggcttggcgt tatgggcagc cttggcggtt ttggcggcat gtttgacctg tctgagcttt 656701 cttatcaaaa accagttctc atttcgggaa cggacggtgt cggcacaaaa ttaaagctcg 656761 ctttttccat ggataagcat gacacgattg gcgtggatgc tgttgcaatg tgtgtcaatg 656821 acgtgctggc acaaggtgca gagccgctgt ttttcctcga ttatttagcg gttggcaaag 656881 cggacccagt gaaaattgaa cagattgtac aaggtgttgc ggaaggctgt gagcagtcag 656941 gttcagcctt agtcggcggt gaaacggctg aaatgccggg gctctataca gctgatgaat 657001 acgatattgc cggtttctca gtcggagtgg cagaaaagga cgaaatcgtg actggagaaa 657061 aaattgaaga gggccatctg ttgatcggcc tcagctccag cggccttcac agcaacggct 657121 tttcccttgt cagaaaagtg cttctggatg atgcggagct ggacctcgat acaacatatg 657181 agccgtttga acgcccgctt ggcgaggaat tgcttgaacc gacaaggatt tacgtgaagc 657241 ctgtgcttgc cgcggtcaaa agcggaaaaa tcgacggcat ggcgcacgtg acaggcggag 657301 gatttattga aaatattccg cgtatgcttc cggaaggctt aagtgcggaa attgatcatg 657361 gctcatggcc gatcccgccg attttttctt tcttgcaaga gtacggcaag ctaaaggaag 657421 aagacatgtt caacgtcttt aatatgggta tcggttttgt tttggcagtc aaagaagagc 657481 atctgacaga tgtgatcgga acgcttgaaa gccatggcga aaaagcctat ttaatcgggc 657541 gtgtgaaaaa aggtgaaggc gtcacattcg gcggtgcggc actttcatga aaaagtttgc 657601 ggtatttgca tcaggaaacg gttcaaactt cgaagccatc gtcacgcgtt tgaaggagga 657661 gaactgggat gcgtcagcag cgctcctcgt ttgcgacaaa ccgcaggcga aagtcatcga 657721 acgggcggaa gcattccaca ttccatcctt cgcatttgag ccgaagtctt atgaaaacaa 657781 ggctgcattt gaacaagcca tcattgaaca gcttcgtctt cacgaggttg aattgattgc 657841 tcttgccggc tatatgaggc tgatcggtga tacgctcctt caagcatatg ggggaaaaat 657901 cattaacatt cacccatcgc ttcttccggc gtttcctgga atcgacgcag tcggacaggc 657961 gttccgggcg ggtgtgaagg tggccggaat caccgtgcat tatgtcgatg aaggaatgga 658021 tacaggtccg atcatcgctc aaaaggcaat cgaaattgat gaacatgata cattggaaac 658081 aatcgaacag cgaattcaca agcttgagca taaatggtat ccgagtgtga ttaaacagct 658141 attaggatta aataacagag gtgaaaaggc atgaccatta aacgtgcatt aatcagtgtt 658201 tcagataaaa caaatctcgt tcctttcgta aaagaactga cagagcttgg cgttgaagtc 658261 atctccacag gcggaacgaa aaagcttctt caagaaaacg gtgtggatgt gatcggaatt 658321 tctgaagtga caggctttcc tgaaattatg gacggccggt taaaaaccct acacccgaat 658381 attcacggcg gccttctggc ggttcgcggc aatgaagagc atatggcgca gatcaatgaa 658441 cacgggattc agccgattga cctcgttgtc gtcaacctct atccatttaa agaaacgatt 658501 tctaaagaag acgtcacgta tgaagaagcg atcgaaaata tcgacatcgg cggacctggc 658561 atgctgcgcg cggcatcaaa gaaccatcag gatgtcacgg ttatcgtcga tccggccgat 658621 tacagcccag tgctaaatca aatcaaagaa gaaggcagcg tatctcttca gaaaaaacgc 658681 gagctcgcgg caaaagtatt ccgtcatact gcggcatatg atgcactgat cgctgactat 658741 ctgacaaatg ttgtcggtga aaaagaacca gagcaattca ctgtgacatt tgagaaaaaa 658801 caatcgcttc gctatggaga aaacccgcat caggaagcaa ctttctatca aacagctctt 658861 cctgtcaaag gctccattgc gcaagcagaa cagcttcacg gaaaagagct ttcttacaac 658921 aacattaaag acgcggatgc tgcagttcaa atcgttcgtg aattcactga accggctgct 658981 gttgctgtga agcatatgaa cccgtgcggc gtgggaacag gaaaaacgat cgcagaagcg 659041 tttgacagag cgtttgaagc ggataaaaca tctatcttcg gcggcattat cgcgctgaac 659101 cgtgaagtgg acaaggcaac tgccgaagcg cttcacaaca ttttcttaga aatcatcatt 659161 gcgccttcat tcagccaaga agcgctcgac gtcctgactg cgaagaaaaa tctccgtctg 659221 ctgacgcttg acgtatccgc cgctgttcaa aaggaaaaac agctgacatc cgttcaaggc 659281 gggctgctga ttcaagattt agatatgcac ggcttcgatg atgctgagat tagcattccg 659341 acaaaaagag agccgaacga gcaagagtgg gaagacttga agcttgcttg gaaagtcgtg 659401 aagcatgtga aatcaaatgc gattgttctc gcgaaggaca acatgacagt cggcgtggga 659461 gcaggccaaa tgaaccgcgt cggatcggca aaaatcgcaa tcgagcaagc aggggaaaaa 659521 gcgaagggca gcgcgctcgg ttcggatgca tatttcccaa tgccagatac tgtcgaagaa 659581 gcggcaaaag cgggcgttac agccatcatt cagccaggcg gatcgatccg agatgaggat 659641 tccatcaaaa aagcggatga atacggcatt gccatggtat tcaccggcat cagacacttc 659701 aaacattaag gggatgaaaa cgacgtgaat gtattaatta tcggtaaagg cggaagagaa 659761 catacgctgg cgtggaaggc agcgcaaagc agcctcgtcg agaatgtatt tgccgctccc 659821 ggaaatgacg gcatggcagc ttccgctcag cttgtaaaca ttgaggaaag cgaccacgca 659881 gggcttgtct catttgcaaa acaaaatcag gtcggcctga ccattgtcgg ccctgaggtt 659941 cctttaattg aaggtctggt ggatgaattc gaaaaagcgg gcttacatgt gttcggtccg 660001 tcaaaagctg cggcgatcat cgaaggaagc aaacagttcg ctaaggattt aatgaagaaa 660061 tacgacattc cgaccgcaga atacgagacg tttacatcct ttgatgaggc gaaggcatat 660121 gtgcaggaaa aaggtgctcc gattgtgata aaagcagatg gacttgcagc tggaaaaggc 660181 gttactgtgg ctatgacaga ggaagaagca attgcgtgct tgcatgactt tcttgaagat 660241 gaaaagttcg gtgatgcgag cgcgtccgtt gtcattgaag aatatctttc tggtgaagaa 660301 ttttctctaa tggcctttgt caaaggggaa aaggtgtatc cgatggtgat tgcccaggat 660361 cacaagcggg cgtttgacgg agacaaaggc ccgaatacag gcggcatggg cgcctactcg 660421 ccagttccgc aaatttcgga agaaacggtc cgccatgctg tagaaacgat cgttaagccg 660481 gctgcaaaag caatggtaca agaaggccgt tccttcactg gcgttttgta cgctggattg 660541 atgcttactg aaaacggctc gaaggtcatt gaatttaatg cccgtttcgg cgatccggaa 660601 acacaggtcg tgcttccgcg catggaatct gatctggtac aggtgcttct tgatctttta 660661 gatgataagg aagttgactt aagatggaag gataccgcgg cagtgagtgt tgtgcttgca 660721 tcagaagggt atccggaaag ctatgcaaaa ggcacgccga tcggcagcct tgcagcagaa 660781 actgagcagg tcgtggtctt ccatgccgga acgaaagcag aaggtggaga gttcgttaca 660841 aacggggggc gcgtcgccaa tgtgacggct tttgatgaaa cgtttgaagc ggctagagac 660901 cgagtgtaca aagcggttga tgaaattttc aaaccgggac tctttttcag aaaagacatt 660961 ggggcacgcg ctttaaaggc tgcccaaaaa taagtgagga aaacccgcag aatagctgcg 661021 ggttttttgt tatcaaaaag cgggatggca gctagaagaa gaaagcacaa cgagcgtggt 661081 tggttttcca tgggccatcg aggtgtcaat aaaatcctca agcgtatgta ccgattcagt 661141 cacgaccttt gtcacatagc tgtacatccc cgtgatgcgg tggttttctg ctacatcagg 661201 atgcgatgtt gcaaaggcgg cgtagtgctt gcagcttttc ggctccatga gaataaaagc 661261 ggtgacatgc ttgtttagtt tttcgtaaca gatattcgcg ctgtagccgg taatcactcc 661321 tttgtcttcc agcttcctga cacgctccgc cgcgcttggc gagctgagtc cgacaagctt 661381 tcccagctca accatcgtta atctgccgtt tcgctgcaaa tgcgagagaa tctgaaggtc 661441 tgtatcgtcc atttgtctgg ctcctttaca tatttaggcg aatgaatgaa aattcctttg 661501 atcgtaaggt aatgctgttg atttaacttc attgtagcat atggatgccg tcttattttt 661561 tctataataa agccatcaat cagagagggg gcatcatgtt gccagaattg cagcgctcta 661621 ttacttggat acaagggacg gcgttaacga ttggggcggt tttaggatgc gggatattaa 661681 tcctgccgtc tgtcaccgcg gacacggccg gccccgcttc tttatttgtt tgggtgttca 661741 tgtccttctt atcctttttt cttgtcggca cgctggcccg gcttgtgaaa atagcgccta 661801 gcgcgggagg aatcacggct tatgtgcagc tggcctttca gaaaaaagcc ggggctattt 661861 tgggctggat catgttaggg tccgttccga tcggcgttcc catcatcgct ttgactggcg 661921 cgcattacgt cagttacatc acagaggcgg ccgattggca gattacattg attgctggtt 661981 gcatgctggc tatatctatt ttgcttcata tgagagggat tcaactatca gcaaacatta 662041 gtacactcgt tatatgtgtc atcgtatttc tgcttgtcac ttctattgct gtgtcattgc 662101 cacacgtcac gatagcagaa ttcaagccgt ttcttccgca tggctggtct gccgctggat 662161 ctgtttctgt tatgattttt ttctcttttg taggctggga aatgattacc ccgttggctg 662221 aggaatttca tcgtcctgaa aaagatgtcc cgctcagctt gtttttggca gcgtcttgtg 662281 tggcggggct gtatatcatg ctgtcatttg tgaccgtggg tactcattca tatggagaga 662341 atggagaaat tgcatcgctt gccatgctca tttcaaaagg agcaggagaa agcggtgtat 662401 atgtcacggt atgtttagcg ctgtttatta cattcgccac catccatgcc aatattgccg 662461 gtttttcaag aatggtgtac gcattggcga gagaggggca catacccgta ttttttggaa 662521 aactcagtgc gacaaaacgt acgcctattc gcgttttgac agcgatggcc gcagtgtttg 662581 gcttagtgct tgcagcgcat ggtctgtttc aaatcgattt gacgactctg ttgaaagggc 662641 cgagcgcggc ttttatcgca tcttacatat gtacaatggc ggcagcactg aaactgctgg 662701 gcaggagaga tataggctgg tggatggcgc tcggggcatt tgtggcgtgc gcggtgattt 662761 attcattcag cggctgggca ctgctttatc cggcagtgct ggcagctgca ggatatttct 662821 atatgaaaac aaagggtggg cataaaaaaa agcttgatca cgttttgtga tcaagctttt 662881 ccatttatcc gttttgatgc tcgttatttc cagaatcgct gtgttgaaac atgtaggtca 662941 caggacagaa gcgcaagatt cccgaacccg ctttcatggc ccccataaag atgtaaaaga 663001 gatgcattct gcaccaaggt tttttcgtaa actttgcact ggcggctgac ataatcgtca 663061 atccgcaggc gattctgaac acggcattga tgagactgat gtttggcttc aaggaaatcc 663121 gctcctttta cttaaaaaag ttttttaatc gaaccttcaa aaatttgtaa cgtttttatc 663181 gtgcgtgatg aggaaggatg tgataccatg agtctaatac atgtaaagga gagtatgtga 663241 atgtccgaac gcacctttaa ctggaaaaac aaagacatca gggcacaggt tgatgttgta 663301 gactcaaagc tgcttccaac gctcctttta cggaatgctc tcgtcttaaa tccatatgta 663361 aaacaatggc tgaaaaaaaa catttggatt tatcaggacc gcattgttta tgtgggtcat 663421 gaacttccga atagagccga agaaattcat acgattgatt gtgaaggaaa atacattgtg 663481 ccaggttata ttgaaccgca cgcacatcct tttcaaatat ataatcccca aacactggcg 663541 gaatatgtgt ctcaatacgg aacaacgaca ttcgtgaatg ataacttatt tttgcttttg 663601 caaagcggaa aaaagaaagc gcttacgatt ttgaatgaac tcaaaaagca gcctgtccag 663661 tatttttggt ggtcacgcta tgacctccag accgaggttc tgaacgagga ccacgtcctt 663721 ccatttgacg tcagaaaaca gtggattgaa catccggatg tgattcaagg cggagaaatg 663781 accggatggc ctcgcctggt agatggtgat gatttaatgc tccactgtat gcaagctaca 663841 aagaaacaga gaaaacgtat tgaagggcat tttcccggcg cttctgataa aacgcttaca 663901 aaaatgaagc tgttcggtgc ggattgtgat catgaagcga tgacaggtga tgaagtgatg 663961 agaaggctgg aactgggcta ttatgtttcc cttcggaact cttccattcg ccccgatgta 664021 agaaaaatct tgcaagagct gcatgagaag ggcttccgct attatgacca cttcttttac 664081 acgacagatg gcgcaacccc gaatttctat aaaggcggca tgacaaacga gctgattcgc 664141 attgcgttag aagaaggcgt acctgcaatc gacgcctaca atatggcatc atttaatatc 664201 gcaaagtatt accaaatgga tgattattta ggagttgtcg gaccgggcag actggcatcg 664261 ctaaacatac tggaagatcc gttaaatccg aatccagtga ctgttctgtc aaaagggacc 664321 attctgcgtg aaaacggctg tgatttgaag gcgtttacaa agacggactg gcacaaaggc 664381 ggtcttgtcc cgcttgagct ttcatatgat atgacgatgg atgacttgca gttttctatg 664441 ccgatgggcg tgaaaatgcg gaatgcggtt attatggagc catatatgat tgagatcgac 664501 aattcgatgg aacagctctc gtttgaccat gatgaaagtt atttgacgat gctcgacaga 664561 cacgggaaat ggcgcgtcaa tacgatgata aaagggtttg cctcaagcgt gcagggattt 664621 gtaagctcct ttacgacgac gggcgacatt gtcgcgattg gaaaaaataa agcggatatg 664681 ctgctcgctt tcgcccgcat gaaagaaatc ggaggaggaa ttgttttagc ggagaacgga 664741 aacattctgc atgaaatccc gcttgcgctg tgcggctgcg cctcttcgga agcgtatgaa 664801 gacgtgcttg agaaggaaca aaagctgaga gatcttttga ctgaaagagg ctatgagttt 664861 tgcgatccta tctatacgct gctctttttg caaagtacgc accttccgta tatacgcatt 664921 acgccaagag gaatattcga cgtcatgaaa aaaactgtac tctttccatc gataatgcgt 664981 taaaatataa aagagcaggg agccgacata tgaaaaaatg gatgacagtt tgcgcgctgt 665041 gtttcgtgtt ttttctgctg gtatcctgcc agcagaagga tgctgtcccg gatactgcaa 665101 agaagctgaa agctccttta acggggctaa agactgaaca gaaagtgact gaacgccgcc 665161 ctgttgctgt tgtggtgaac aatcacccga aggcgaggcc gcagtcgggt ctgtctaaag 665221 ccgacattgt catagaagcg ctagccgaag ggcaaatcac aagatttctg gccattttcc 665281 aaagccagat gcctgaaact gtcggacctg tgcggagcgc gcgggaatat ttcgtcactc 665341 tcagcaatgg ctttgacagc atatttgtcc atcacggctg gagtcccggc gccaaaaagc 665401 agctggaatc cggagctgcc gattatatga acggattgga ttttgacgga agcttatttt 665461 ggagagctga tttcagcaaa ccgccccaca attcctatac gtcttatgat tacataaaaa 665521 aggcggcaga acaaaagggt tataagctga agcaggaaac aaatccgctg ctgtttcaaa 665581 catcagatgc aaaacctgca aatgaatctt acaatgttcg ggtagattat ggaacaaata 665641 acgttacaaa tcttgtcgaa tacaactatg ataaaaaagc tgaattttat acaagaagct 665701 ctgatggtgt cataacgaca gaccgggaaa ccggaaagcc ggttgcaatg caaaatattt 665761 tcattgttga agccagccat catattattg atcaagatgg aaggcgggac atcgacttgg 665821 aatcaggagg aaaaggtctg ttgtttcagc acggaaacgt cattgaaaca gactggaaac 665881 aagtgaatgg cagaattgtg ccggtaaaag acggcaagtg gcttccgttt gtgccaggaa 665941 agacttggat caatatcgta cctgatcttg atgcggcttc cattagtaaa ggagaaggtg 666001 tgtaacgatg caaatcgata aattacgcgg caaagagctg gaccagttat ttaactcgat 666061 cttatcgctg aaagacctgg aggaatgtta ccgattcttc gatgatctat gcacaattaa 666121 cgaaattcaa tcgctggctc agcgccttga agtggcgcgc atgcttcgcg aaggaaacac 666181 gtatcataag attgaaacag aaacaggcgc ttccacggct acgatttccc gtgtgaaacg 666241 ctgcttaaat tacggaaatg acgcttatga aatggcgctt gaccgtgtga aggagacgga 666301 aacagagtct tcttccaaat aaaaaaccgc cctgccgtct ggcaagggcg gtttctttat 666361 gaaacaaatt gatggatcag gttgtcgata ttgatgatac tgccatcctc tttccgatag 666421 acaacatgct ccttggaaaa atgaatcggc gaattaatcc ctgctgcggc tgcaaggtta 666481 aatagtccct cgcgcaatga aataacgtag ttgcagacac gatgctgttt ttcctcaacg 666541 ctcagtgctt tttgcaattt cggatctgtc gtcgccacac ctgccggaca ggtgttggtg 666601 tggcagacga gagcgcggat gcagccaacg gaaaacatca tgccgcgtgc gatgttaaca 666661 aagtcagcgc cgagggctaa ggcgaccgcg attttatcag gagtcaggag ctttccggaa 666721 gcaaagattt tcagctggct gcgcaagccg tactgtttaa gaagcgtgtc cacaataggc 666781 agcgctgtca taatcggaag gccgactgta tccgcgagct cgtaaaagga agctccggta 666841 ccgccttcac ttccgtcgat cgtgataaaa tccggatgct ttccgctttt ctgcatatga 666901 gagaaaagct catgcaattc ttcaggatgc cctgcgacca gtttgatgcc gactggcttt 666961 tgtccgacat ctctaagttt ttcaataaag tcgagcattt caggagggtt tgagaattca 667021 taaaagcggt tcgggctgtc aatcgacttt ccaggttcga cattccgaat gtctgccact 667081 tcctctgata ctttggcgcc gtccacatgg ccgccgcggg ttttcgctcc ttgtgccagc 667141 tttagctcaa acgctttaat ctggtcaatc ctgctttttc ttttaaattc ctcccacgaa 667201 aattccccgt ttcttttgcg cacgccgaat aggcccggtc cgatttggca aatgatatcg 667261 gcgccgccct ttaagtgata ttcagacaat cccccttcac ctgtattcat ccaggtgccg 667321 cctgccagat ggagcccttt tgagagcgcc gtaacagccc gttctccaag agaaccgtag 667381 ctcatggcag actggccgac taagcccttc acataaaatg gcttctcgca tgtatgctcg 667441 ccaatcacct gtacatcatc aggatggaga aaatacgggt ctgccttgat atgttcggca 667501 tgctccttgc gtttgaacag attgtcagca tccattttat agatttgggt ttcaattttt 667561 ggcgtttgat ttacatgcat ttcttccctt tgttttggaa acatagcgtt acggatataa 667621 tagccaggtt tatcaaaatc tcttacagat ccaaagccca tcattctgct tttgtatttg 667681 ccggagatga cggtttgctc atattccttt cgtgaaaatg gctgctcttc attgtcattg 667741 ctgtataaat actgtctgag ctccggcccg attttttcaa ggatataccg aaaccttccg 667801 atgacgggat agttgcgaag aattgagtgc tcctgctgtt tttcatcctt tatgtagatc 667861 caggcaaaca agacgatcgg gatagcgatg atcccaatga taaatgcgat gagtgctatt 667921 atgatggttt ccatctctca gcctcccttt ttatgtaacc atttccacag tagaacactt 667981 tccaaacaat agcagaagga atctggtgaa aaatgtgtgc tcctgccgat acaggactca 668041 ccatgcaggt actgccatat gctctctttt tttatgaaaa aagaatcaaa acaccttttt 668101 cagtgaataa cgagattaac ggctttttcc gtttttccgc gctatgtgaa tttgttataa 668161 tgtttaaatg gtaacaaacg aatggaggaa cgtatgacgt gtacgatgta acggagtgga 668221 agcatgtctt taaactcgat ccaaataaag atttgcctga cgaacagctg gagattcttt 668281 gcgaatcagg aacggatgcg gtcattatcg gaggaagcga tggtgtgaca gaggataatg 668341 tcctgcggat gatgtctaag gtaagacggt ttttggtgcc gtgtgtccta gaggtatcag 668401 cgattgaagc gattgttccc ggctttgact tatattttat tccgagtgta ttaaacagca 668461 aaaacgcgga ttggattgtc ggaatgcacc agaaagccat gaaggaatac ggagaactga 668521 tgtctatgga agaaatcgtg gcggagggct actgcatcgc aaatccagat tgcaaagccg 668581 cggcactgac tgaagcggac gccgatctga atatggatga tattgtcgcc tatgcgcgtg 668641 tgtcggagct gctgcaactg ccgatttttt atttagaata cagcggcgtg cttggagaca 668701 tagaagctgt caagaaaacg aaggctgtat tggaaacgtc caccttgttt tacggcggcg 668761 gcatcaagga tgcggaaacg gccaagcagt acgcagagca tgcggacgtg atcgttgtag 668821 gcaatgcggt gtatgaagat tttgacaggg ctttgaaaac agtagcggct gtgaaaggcg 668881 agtagtaaat tgtacggatt tggtttatga tagaacgtat gttttgtata ggcgggtgaa 668941 caaattttga attatattag caatcaatta ctaagcggtt taaaccccgt tcagcaggaa 669001 gcagtcaaaa caacggacgg gcctcttttg ctgatggcgg gagcgggtag cggaaagacg 669061 cgtgtcctga cccatagaat tgcttattta atggcagaaa agcatgtggc gccgtggaac 669121 attctggcga tcacatttac aaataaagcg gcacgcgaaa tgaaagaacg tgtggaaagc 669181 atcctcggac ccggcgcgga cgatatctgg atctccacat tccacagcat gtgcgtgcgg 669241 atcttgcgca gagatatcga ccggattggg atcaaccgaa atttctccat ccttgatacg 669301 gctgaccagc tttcagtgat caaggggatt ttgaaggagc gcaatcttga tccgaagaag 669361 tttgacccga gaagcatcct cggcacgatc agcagtgcaa aaaacgaatt gaccgaaccg 669421 gaggaattct ctaaagttgc tggcggctac tacgatcagg tggtcagcga tgtatatgct 669481 gattatcaga agaagctatt gaaaaaccag tcgctcgatt tcgacgattt aattatgacg 669541 acgattaaac tgtttgacag agtgcctgaa gtgcttgaat tttatcagcg caaattccag 669601 tacatccacg ttgatgagta tcaggatacg aacagggcac aatacatgct cgttaagcag 669661 cttgccgagc gtttccagaa cctttgcgtt gtgggggatt ctgatcagtc aatctacaga 669721 tggcgcggcg cggatatcac caacattctt tcatttgaaa aagattatcc gaatgcaagc 669781 gtgattttgc tagaacaaaa ctatcgttca acgaaacgga ttttgcgcgc ggctaacgag 669841 gtcattaaaa acaactctaa ccgcaaaccg aaaaatttgt ggacggaaaa tgatgaaggc 669901 atcaagattt cctattatcg cggtgataat gagttcggtg aaggacagtt tgtggccggc 669961 aaaattcatc agcttcacag cacaggcaag cggaagctgt cggatatcgc catattatac 670021 cggacaaacg cgcagtcccg tgtgattgag gaaacgcttc tcaaagcggg cttgaactat 670081 aacattgtcg gcggcacaaa gttctatgac agaaaagaaa ttaaagacat tcttgcgtac 670141 ctgcgcctcg tatccaatcc ggatgacgat atcagtttca cgcgcattgt caatgtgccg 670201 aagcgcggag tcggcgcgac atcacttgaa aaaatcgctt cgtatgcggc cataaacggc 670261 ttgtcctttt tccaagcgat tcagcaggtt gattttatcg gcgtcagtgc caaagcggca 670321 aacgcgcttg acagctttag acagatgatt gaaaacctga ccaatatgca ggattactta 670381 tccattacag agctgacaga agaaattctt gataagacgg aatacagaga aatgctgaag 670441 gctgagaaat cgatcgaagc ccaaagccgt ttagaaaata tcgacgagtt cctgtctgtt 670501 acgaaaaact ttgaacagaa aagtgaagac aagacactcg ttgcgttcct gacagacttg 670561 gcattgatcg cagatattga tcagctcgat cagaaggagg aagagtcagg cggcaaggat 670621 gcgatcaccc tgatgacact gcacgccgcg aaaggactgg agtttccggt tgttttcttg 670681 atggggcttg aagaaggcgt cttcccgcat agccgttcac tcatggagga agcggaaatg 670741 gaagaagaac gccgccttgc gtacgttggg attacaaggg cggaacagga gctttatctg 670801 accaatgcta aaatgcgcac cttgtttggc cggacaaata tgaacccgga atctcgcttc 670861 attgctgaaa taccggatga tttattggaa aacctaaatg agaaaaaaga aacaagagcg 670921 acgtctgcga gaaaaatgca gccgagacgc ggccctgttt cacgcccggt atcctacgcc 670981 agcaaaacag gcggcgacac cttgaactgg gcagtcggag ataaggcggg ccataaaaaa 671041 tggggaacag gaactgtcgt cagcgtgaaa ggcgaaggag aagggacaga gcttgatatt 671101 gccttcccga gccctgtcgg cgtgaaacgc ctgttagcag catttgctcc tattgaaaag 671161 cagtaattga agaggaaagg aagaagcaga tggacaaaga aacagcgaag cagcgggcag 671221 aagaactgcg ccgcaccatc aacaagtata gctatgaata ttacacctta gatgaaccga 671281 gcgtcccaga tgccgaatac gacagattga tgcaggagct gatcgcgatc gaggaggagc 671341 acccagacct cagaacgcct gactctccta cgcagcgcgt cggcggagcc gtgcttgaag 671401 cgtttcagaa agtcacccac ggcacaccga tgctcagtct gggcaacgcc tttaatgctg 671461 atgatcttcg tgatttcgac cgccgtgtgc gccagtccgt cggcgacgat gtggcgtata 671521 atgtggagct gaaaatagac ggtcttgctg tttctctccg ttatgaagac ggctattttg 671581 tcagaggggc cacaagaggt gacgggacga cgggagagga tatcacggag aatctgaaga 671641 cgatccgcaa tatccccctt aaaatgaacc gtgagctgtc gatcgaagtg cgcggcgagg 671701 cgtatatgcc gaagcgttcg tttgaagcac tcaatgagga acggattaaa aatgaggaag 671761 aaccgttcgc caatccgcga aatgccgcgg cgggatctct cagacagctc gatccgaaaa 671821 ttgcagcgaa acgaaacctc gatatcttcg tctacagtat agcggagctt gacgagatgg 671881 gtgtagagac gcaaagccaa gggcttgatt ttctcgacga actcggattt aaaacgaatc 671941 aggaacgaaa aaaatgcggc agcatagaag aagtcattac gctgatcgat gagcttcagg 672001 cgaagcgcgc ggacctgccg tacgaaatag acggcattgt cattaaagtc gattctctcg 672061 atcaacagga ggagctcggt tttacggcga aaagcccgcg ctgggccatc gcgtataagt 672121 ttcctgctga agaggtcgtg acgaagcttc tcgatatcga attaaatgtc ggcagaacgg 672181 gtgtgattac gccgactgcg attcttgagc cggtaaaagt tgccggcaca acggtctcaa 672241 gagcatccct tcataacgaa gatttaatta aagagaagga cattcggatt ttggataagg 672301 ttgtcgtcaa aaaagcgggc gatatcatcc cggaagttgt gaatgtcctc gttgaccagc 672361 gcacaggaga agaaaaggaa ttcagcatgc cgacggaatg tcctgaatgc ggcagtgaac 672421 tcgtccggat cgaaggagaa gtggcgcttc gctgcattaa ccctgaatgt ccggcgcaaa 672481 tccgggaagg gcttatccat ttcgtttccc ggaatgccat gaacattgat gggctcggcg 672541 aacgagtgat cacacagctg tttgaggaaa accttgtccg caatgtggca gatttatata 672601 agctgacgaa ggaacgagtc atccagctcg agcgcatggg cgaaaagtcc actgaaaacc 672661 tgatcagctc catccaaaaa tcaaaagaaa attcgttaga gcgcctgctg tttgggcttg 672721 gcatccgttt tatcggatca aaggccgcaa agacgcttgc catgcatttt gaaagcttgg 672781 agaacctgaa aaaagcctct aaagaggaac ttctcgcggt agatgaaatc ggtgaaaaaa 672841 tggctgatgc tgtgatcacc tattttcata aagaagaaat gcttgaactc ttgaatgaac 672901 ttcaggagct gggcgtaaac acgctctaca aaggcccgaa aaaagtaaaa gcagaggaca 672961 gcgactctta ctttgctggt aaaacaattg ttctgacagg aaagctggaa gagctgtcaa 673021 gaaacgaagc caaagcgcaa atcgaagcgc tgggcggaaa gctgactgga agcgtcagca 673081 aaaacacaga cttagtcatc gccggagaag cggcgggaag caagctgaca aaagcacaag 673141 agctgaacat tgaagtgtgg aatgaagaac agttaatggg agagctaaag aaataagagg 673201 agtgttttct attgaaaaag acgttggcat tggcggcaac ggcggcagta ttaatgctgt 673261 ctgcctgctc gtcaggtttc gggggggaga aggaggaaga gattacgcaa aagacggcga 673321 aatcgtcaga aaaagcgatt gtcccgaaat ataatatctc tgactcctat tacaaaatgg 673381 tgctgccgtt taaggcaggc aaagcgcgcg gcttaacaac ggaacagctg aatacaaggc 673441 tggacattga cgaatttgaa acagggctga tgcgccttgc ccaagattct ttctcaactg 673501 acgattatct gttccaagaa ggacaatatt tagatgagga tacagtatta agctggctgg 673561 cacggaaaaa aacgggctct gatttgaaaa aagccgaaaa agaagataag aacttcaaaa 673621 atgaaggctt gaacccggcg ctcccgagtt ctggttcaac agaagaaaag aacgaaagca 673681 gcccaattta tttagcatcc atgcttgagc acgattattt agtcagaaaa gacaagaatt 673741 ctatccagct tggcggcgtc atgatcggac tggcgttaaa ctcagtgtat tactatcgtg 673801 aaaaaactgg cgacccgcaa aaagaagtgg agattaaaga cagcacgctt cgccagcagg 673861 gagaaaaaat tgcacaggag gttattaacc gcctccgcaa aaaagataac ttgaagaatg 673921 tgccgattac cgtggcgctc tacaagcagg cgtcaaaaac atcgattgtg ccggggaact 673981 tcatcgccaa aacagaggtc aaagcaggct ctactgatat ctcaaattgg gatgacatca 674041 atgaaaaata tgtattctat ccggcggata caaccacagc agaaaagtac ccggatgaca 674101 ccgaggtctt taagcggttc aaaaactcaa ttgaagaata tttcccgaac tatacaggcg 674161 ttgtcggtac agcgctgtat gaaaatgatg aaatgaagaa aatgaagatt gacataccaa 674221 tgcaattcta cggaaaaagt gaagttgtcg cgtttaccca gttcttaacg ggtgaagtga 674281 tggactacta ctctaagagc tcagttgatg tcgaagtcaa tatcacgtcc tcagacggac 674341 aggaagcggt cattatccgc aatgccggag ataaagagcc gactgttcac atttatgact 674401 gatagaaaac ccttgtgcca tattggcaca agggttttta tgttacaatt aacaggaaaa 674461 gggaaaatat tttcacttct gccgaaacac aaatcaaggg gaggtatgtt gatgctggaa 674521 atcgtgtgaa aacaatcatt atcaaatcta tagcaatgaa aggatgttag acgtgcataa 674581 agatatcaaa aaaatatttc atgaagagca ggttttggca gaagctgcag cgagatacgg 674641 tttctcaaaa gatcaggtgc gttttctggc tgatgcggaa aactatgtat atgaatgtat 674701 gaaagacaat caaccttata ttttaaagat tacccatacg attcggagat cttctgatta 674761 tatgatggga gagatggaat ggctccgtca ccttgcaata gggggaattt cagtagccaa 674821 accgctcccg tcgctgaacg gaaaagacgt agaagcagtg ccggacggaa acggcgggtc 674881 atttttattg agagtgtatg agaaagcgcc ggggcaaaaa gtggatgaat cggactggaa 674941 tgaaacgcta ttttatgagc ttggcagata cacaggcagc atgcacagcc tgacaaaaag 675001 ctacaaattg agcaatcccg ctttcaaaag acaggaatgg gatgaagagg agcaattaaa 675061 gctgagaaaa tatgtgcctg aagatcagat aaaggtgttt cagcaagccg attctttgat 675121 gaatgaactg cggaggctcc cgaaaagcca ggacaactac ggcttggtgc atgcggatct 675181 gcaccatggc aattttaact gggatcatgg caaaatcacg gcatttgatt ttgatgatat 675241 cggctacaac tggtttgtta acgatattag cattcttctc tacaatgtcc tgtggtatcc 675301 tgttgtgcca tatgatgata aagctgcgtt tacagaagaa tttatgacgc attttatgaa 675361 agggtactgg gaggaaaatg agcttgaccc tgcatggctg atgataatac ctgatttcct 675421 ccgccttcgc catatgctga tttacggatt gctgcatcag atgtttgacc ttaacacaat 675481 aggagaagag gaaaaagaaa tgctggccgg tttcagaaga gatatagaga atggcacgcc 675541 gattacagca tttgattttt cagcactggt gtagatagaa aaagccaatg ggattccagt 675601 cccattggct tttataatgt atcacacttc acgccgacta cgccttcaat ggctttaatg 675661 tcatagtaga catcggtcgt gtatctgttt ttatggacgc ggaccttcac ttccataatt 675721 ggaaaatcct tttcgcctag gtcgtcgatc cgaacggagt gtgctttgat atctcttctt 675781 ttcatttctt ttaaaatctc tgtcattttg tctttatcag aaagtgacat tctgatgcgg 675841 atgtcttttt cctgcaggcg gtcggggccg atttttctga ccacccatgg gagaaattcc 675901 acactgatca ggatgaacag aagactggca aacgcttctt tataaaaacc ggctcccgta 675961 gcaagcccga gccccgctgc cccccagatc atggccgatg tcgtcaggcc ggaaatgaca 676021 tcattgcttt ttcgcaggat gacaccggcg ccgataaacc cgacgccgga gatgatttgt 676081 gccggcagac gaagcggatc catcatgatg cggtagtatt tagggaaatg atatgccgca 676141 ttaatactga cgatcgtcag catgcatgag ctgactgcga tgacaataca ggtttttaat 676201 ccgagcggct tattttttaa ttcgcgttca agcccgatga ccatgccaat caatgtggca 676261 atgcccaatt tcaataaaat atcaggatca atataccagc tcaacagcaa acttccccct 676321 tctctatggt gtttttaaat aaatatgatt ttctcacagt atttatagca aaacaagagc 676381 acaaaagcca ccaagctgcg cttgatggct tattgcttac tttttgcgtt ttaacagctt 676441 ttccatgaca ccgaataatc ggtaagaggc ttttgcagga cgttttgtga tcatgctgac 676501 aatgatgccg gcaatcatac tgagaataaa cccagggatg atttcgtaca caccggttga 676561 ttttgccagg ccggttgtaa tccagatcaa cacggtcgca gccccgacaa tcatggcagc 676621 aagcgcgccc cattcgttca ttcgtttcca atacagactg agcagaatcg caggcccgaa 676681 agctgaaccg aagccggccc aagcgtatcc gaccaaatca agaatggtgc tgttcgggtt 676741 caatgacaag agtaccgcga taacggcaat gactaagacg gacaatcgcc cgatcatgac 676801 caattcttta tcagaagctt ttcgtctgaa aaatgaccgg tataaatcct ctgttacagc 676861 acttgctgtg accaagagct gtgaggaaat cgaactcatg atggcagcca aaatagctga 676921 caataagaac cctgtaatta atgggtggaa caagatttta gagaagataa tgaaaatcat 676981 ctccggatct tttacagcaa ctccgaattt atgggcgtat gcaacaccga ttaaacccgt 677041 cagcacggaa cctagaactg taatgatcat ccagctcatg ccgattcggc gtgcaggttt 677101 taaatcttta atgtctttaa tggccataaa tcggacgatg atatgaggct ggccgtagta 677161 gcccaacccc caggctaaat aggaaataat gctaatgacg ctcgcgcctt taaaaatatc 677221 caataaatgt ggattaacag cgtcgatttc atggaaagtc ggagcaacgc cgcccacatg 677281 ggtaaaagca acgatcggca caagcactag tgctgcaaac atgatcgcac cctgcacgaa 677341 gtcagtcaga ctgacagcaa ggaaaccgcc aaacagtgtg tataacacga caactgcggt 677401 ggtcagaaac aggcctaatt tgtaatccgc accaaaagca gattcaaaca gccgtccgcc 677461 agataccata ccggaagagg tatacaatgt gaaaaagatc atgatgatca atgcagatac 677521 gattttcagc agtgatgaag aatgctggaa tcgtttatca aagaaatcag gaattgtaat 677581 cgcatcatct gccgcttctg tataagcacg cagccttgga gccagcagca agtaatttga 677641 gtacgccccg attgtaagac ctaaagcaag ccataaggtg gacagccctg tcgcaaacat 677701 cgcgccggga acacccatca gcatccatcc gctcatatcg gccgcgccgg cagacaaagc 677761 agtaacgaat ggtccgaggc ctcttcctcc aagcatgtaa tcattgatgt cagtggtttt 677821 cttgaatgca taccagccga ttaacagcat ggcaataaag taaattccta aagatataat 677881 aatttcaata ctcacgtttt accctctctt catttctaat aatgttgcat cacctctcaa 677941 attgatggtg ccagttaagc agcctggcgt aagtgcaaaa caaaagaaat tcttttgcgg 678001 gtgcacttgg taacttaacc taacaaagta ttcccggcca ttcaagcgat gaaacattga 678061 tcataagctg gaaataccgt tgcaaaccta gaagggaata aagaataaaa cgctttcaaa 678121 aaataattaa agtaaaaata ttcagaaaaa tatttcgttt ctccttctcc tcattttagt 678181 ataaaatata tagggtattg tttcgaaaac acaggcctgt ctcaaggcgt tttgttgctt 678241 taaagggctt gtttttgata tgatcagtat tatatgactt aacggagaaa tatgtggagg 678301 tggatcatat gtcacgaatt tcaatagaag aagtaaagca cgttgcgcac cttgcaagac 678361 ttgcgattac tgaagaagaa gcaaaaatgt tcactgaaca gctcgacagt atcatttcat 678421 ttgccgagga gcttaatgag gttaacacag acaatgtgga gcctacaact cacgtgctga 678481 aaatgaaaaa tgtcatgaga gaagatgaag cgggtaaagg tcttccggtt gaggatgtca 678541 tgaaaaatgc gcctgaccat aaagacggct atattcgtgt gccatcaatt ctggactaaa 678601 ggagggacac aagaatgtca ttatttgatc ataaaatcac agaattaaaa cagctcatac 678661 ataaaaaaga gattaagatt tctgatctgg ttgatgaatc ttataaacgc atccaagcgg 678721 ttgatgataa ggtacaagcc tttttggcat tagatgaaga aagagcgcgc gcatacgcga 678781 aggagcttga tgaggcggtt gacggccgtt ctgagcacgg tcttcttttc ggtatgccga 678841 tcggcgtaaa agataatatc gtaacaaaag ggctgcgcac aacatgctcc agcaaaattc 678901 tcgaaaactt tgatccgatt tacgatgcta ctgtcgttca gcgccttcaa gacgctgaag 678961 cggtcacaat cggaaaactg aacatggacg aattcgccat ggggtcatct acagaaaact 679021 cagcttacaa gctgacgaaa aacccttgga acctggatac agttcccggc ggttcaagcg 679081 gcggatctgc agctgcggtt gctgcgggag aagttccgtt ttctcttgga tctgacacag 679141 gcggctccat ccgtcagccg gcatctttct gcggcgttgt cggattaaaa cctacatacg 679201 gacgtgtatc tcgttacggc ctggtcgcat ttgcgtcttc attggaccaa atcggaccga 679261 ttacacgtac ggttgaggat aacgcgtttt tacttcaagc gatttccggc gtagacaaaa 679321 tggactctac gagtgcaaat gtggacgtgc ctgattttct ttcttcatta actggcgaca 679381 tcaaaggact gaaaatcgcc gttccgaaag aataccttgg tgaaggtgtc ggcaaagaag 679441 cgagagaatc tgtcttggca gcgctgaaag tccttgaagg tctcggcgct acatgggaag 679501 aagtgtctct tccgcacagt aaatacgcgc ttgcgacata ttacctgctg tcatcttctg 679561 aagcgtcagc gaaccttgca cgctttgacg gcatccgcta cggctaccgc acagacaacg 679621 cggataacct gatcgacctt tacaagcaaa cgcgcgctga aggtttcgga aatgaagtca 679681 aacgccgcat catgctcgga acgtttgctt taagctcagg ctactacgat gcgtactaca 679741 aaaaagcgca aaaagtgcgt acgttgatta agaaggattt cgaggacgta tttgaaaaat 679801 atgatgttat tgttggaccg actacaccga cacctgcgtt taaaatcggt gaaaacacga 679861 aggatccgct cacaatgtac gcaaacgata tcttaacgat tccggtcaac cttgccggcg 679921 taccgggaat cagtgtgcca tgcggattag cagacggact tccgctcggc ctgcaaatca 679981 tcggaaaaca ctttgatgaa agcactgtat accgcgttgc tcatgcattt gaacaagcaa 680041 cagaccatca taaagcaaaa cctgaactgt aaggggtgaa aagaattgaa ctttgaaacg 680101 gtaatcggac ttgaagtcca cgttgagtta aaaacaaaat caaaaatttt ctcaagctct 680161 ccaacgccat tcggcgcgga ggcgaatacg cagacaagcg ttattgacct cggatatccg 680221 ggcgtcctgc ctgttctgaa caaagaagcc gttgaattcg caatgaaagc cgctatggcg 680281 ctcaactgtg agatcgcaac ggatacgaag tttgaccgca aaaactattt ctatcctgac 680341 aacccgaaag cgtatcagat ttctcaattt gataagccaa tcggcgaaaa cggctggatc 680401 gaaattgaag tcggcggcaa aacaaaacgc atcggcatca cgcgccttca tcttgaagag 680461 gatgccggaa aactgacgca tacgggcgac ggctattctc ttgttgactt caaccgtcaa 680521 ggaacgccgc ttgttgagat cgtatcagag ccggacatcc gcacgccgga agaagcgtac 680581 gcatatcttg aaaagctgaa atccatcatc caatatacag gcgtttctga ctgtaaaatg 680641 gaagaaggct cacttcgctg tgacgccaat atctctcttc gtccgatcgg ccaagaggaa 680701 ttcggcacaa aaacagaatt gaaaaacttg aactcctttg cgtttgttca aaaaggcctt 680761 gagcatgaag aaaaacgcca ggagcaggtt cttctttccg gcggcgtcat ccagcaagaa 680821 actcgccgtt atgatgaagc aacgaagaaa accattctta tgcgtgtcaa agagggatct 680881 gacgactacc gttacttccc agagccagat ctagtcgagc tctacattga tgatgaatgg 680941 aaggaacgcg taaaagcaag cattcctgag cttccggatg agcgccgcaa gcgttatatc 681001 gaagagcttg gcttgcctgc atatgacgca atggttctga cgctgacaaa agaaatggct 681061 gatttcttcg aagaaaccgt tcaaaaaggc gctgaagcta aacaagcgtc taactggctg 681121 atgggtgaag tgtcagctta cctaaacgca gaacaaaaag agcttgccga tgttgccctg 681181 acacctgaag gccttgccgg catgatcaaa ttgattgaaa aaggaaccat ttcttctaag 681241 atcgcgaaga aagtgtttaa agaattgatt gaaaaaggcg gcgacgctga gaagattgtg 681301 aaagagaaag gccttgttca gatttctgac gaaggcgtgc ttctgaagct tgtcactgag 681361 gcgcttgaca acaatcctca atcaatcgaa gactttaaaa acggaaaaga ccgcgcgatc 681421 ggcttcctag tcggacagat tatgaaagcg tccaaaggac aagccaaccc gccgatggtc 681481 aacaaaattc tgcttgaaga aattaaaaaa cgctaataaa aaagcagccc ttagaggctg 681541 ctttttttat ggtcaaattg agataaagac aagatgaggg cccgaagcct ttcaacttct 681601 ttgtcgttgg ttccggccaa attggacagc atgcctttaa taatcggctt gcgcggttta 681661 tcctgagtca attcttcctc gataacatca agtgacacgg tgatatcctc gggcagcgtg 681721 ctgttttctt tcactttctg aatgtcctca agcagctggt cttttcccgc aggcatcggg 681781 ttaaaaatgt cttttgatac aatcggattg agtgcagaac ggctcagccc ctgtacaaga 681841 tcatccagtc tctcaataat aaaggctgag atttcttctg catcgatatt aagctcaccg 681901 ttaaatacca tcacgttcat ataggaatgc acaatgcctc ttgccatgat ggacagatct 681961 gcgacatacc gctcgattcc ttcgccatag gataccagca aggcgttccg gtacagctta 682021 tccgtctcca tggttacttt gtaaaagtat tgcttgattt cttgattttc cggaatgata 682081 ttttcggtaa gcaaaagaac gataaaatct ttatgatcgc gaaaatcctc aaattgagcg 682141 ccaatttgct tttttaacac ttccttaggc ggctttccgg cgagatcttc ttctatattt 682201 ttcattttgt tcatagacat accgatataa tattcacagg cagataacag cagcgcttct 682261 ttcgatttga agtgcaaata aaaagcgccc ttcgaaatgc cgcattcact ggcgatttct 682321 tggatcgtcg tagctgcgaa tccttttttc gcaaataaac gaatgctggt ttttatgatt 682381 ctctcttttt tttcattcat gacgtgcttc cccttaatcc ttgaaaaatt tagtaaaatt 682441 ttctggtata tgagttgacg ttgttgcgtt ataacgttta gtattatata gaatgaccag 682501 tcagtcaata aaaaatgtaa tggaggatat gatgaaccac gttattaatt tcgttctgaa 682561 aaacaaattc gccgtatggc tgatgacgat tattgtaacg gcagccggct tgtatgcggg 682621 tatgaatatg aagcaagagt ctattcctga cgtgaacatg ccttacttga cgatcagcac 682681 gacatatccg ggtgcaacac caagccaagt ggctgatgaa gtgaccaaac cggttgaaca 682741 agccgtacag aacttggacg gtgtcagcgt tgtgacgtcg acgtcctatg aaaacgcatc 682801 gtcggtcatg attgaatatg attatgagaa agatatggac aaagcgaaaa cagaagcagc 682861 tgaagcgtta gaaaacgtca acctgcctga tgacgcgaag gatccggaga tttcacgcta 682921 cagcttgaac tcattcccga ttctgacgct gagcgtgtcc agtgataaag ataatctgca 682981 agagctgacg aaacaagtgg aggacagcct cgtttctaag cttgaaggca tagaaggcgt 683041 tgcgtccgtc caagtatcag gccagcaggt ggaagaggtt gaattctctt tcaaagaaga 683101 caaactgaag gaatacggcc ttgatgaaga tacagtcaag caagtgattc aaggttcaga 683161 tgtgacaact ccgcttggat tgtacacatt cggaaatgaa gaaaaatctg tcgtcgtcag 683221 cggcgatatt gaaacaatta aagatttgaa gaatatgaga atcccgacgg catctgcttc 683281 aagtgcaggc agcagcgcag catctcaagc aggtgcgcag agtgctcaag cagcccaaag 683341 cgcgcaagcg gcagcacagg tgcagcaaag cgcaagcaca gcagtgccga cggtcaagct 683401 ttctgacatt gctacaatta aagatgtgaa aaaagctgaa tccgtttcac gcacaaatgg 683461 caaagacagc atcggcatca acatcgtcaa agcaaacgat gcgaatacgg tagaggttgc 683521 cgacgatgtc aaagctgagc tgaaaaagtt caaagaagac cataaaggct tcaattacag 683581 cgcaactctc gacatggcgg agccgatcac acagtcagtt gacacgatgt taagcaaagc 683641 catcttcggt gctatttttg cgattgtgat tattctctta ttcttaagag atatcaaatc 683701 aacattaatt tctgttgttt caattccatt atcattgctg atcgcactcc ttgtgctgca 683761 gcagcttgat atcacattga atattatgac gctcggcgca atgaccgttg ccatcggacg 683821 tgtagtcgat gactccatcg ttgtgatcga gaacatttac cgccgcatga gactcaaaga 683881 tgagccgctc cgcggaaaag ccttggttcg tgaagcgacg aaggaaatgt ttaaaccgat 683941 catgtcatca acgattgtga caatcgcggt attcctgccg ctcgcacttg taggcggaca 684001 aatcggtgaa ttgtttattc catttgcctt aacgattgtt tttgcgcttg ccgcatccct 684061 agtgatttca atcacgcttg tgccgatgct cgcacacagc ctgttcaaaa aatcattaac 684121 cggtgcgccg attaaagcga aagaacacaa acctggcaga cttgcaaaca tctataaaaa 684181 agtattgaac tgggcgctga gccacaaatg gatcacgtct atcatcgcgg ttctgatgct 684241 ccttggaagc ttgttcctcg taccgttaat cggtgccagc tacctgccgt ccgaggaaga 684301 aaaaacgatg cagctcacat acagcccaga accgggtgaa acgaaaaaag aagccgaaaa 684361 tgaagctgaa aaagcggaaa aaatcctgct tgaccgcaag catgtcgata cggttcagta 684421 ttcattaggc tctggcagcc cgcttgccgg aggagattct aacggtgcgt tattctatat 684481 caaatatgaa agcgacacac ctgactttga taaagaaaaa gataacgttc tgaaggaaat 684541 ccaaaagcaa tctgaccgcg gagaatggaa gtcacaggac ttcagctctt caggcaataa 684601 taacgaatta acatactatg tgtatggcga ttctgaaaac gatattaaag acacggtcaa 684661 agacattgaa aaaatcatga aagatgaaaa ggatctgaaa aacgtaaatt caggcctttc 684721 cagcacatat gatgagtaca catttgtcgc tgaccaagaa aaactaagca agctcggttt 684781 aaccgcgtct caaatttctc aggccttaat gtcacaaaca tcgcaagaac cgctcaccac 684841 tgtgaaaaaa gacggcaaag agcttgatgt gaacattaag acagaaaaag acgagtataa 684901 gagtgtgaaa gatttagaga ataaaaagat cacttccgcg actggccagg aagtcaaaat 684961 cggcgatgtg gcaaaagtga aagaaggatc aacatcagat accgtgtcaa aacgtgacgg 685021 aaaagtctat gcagatgtca caggtgaggt tacctctgac aacgtcacag ccgtatcagc 685081 tgctatccag aagaaaatcg ataagcttga ccaccctgat aacgtatcga ttgacacagg 685141 cggcgtatca gcggatatcg ctgattcctt cacgaagctc ggtttagcga tgctggcagc 685201 aatagcgatc gtttaccttg tgctcgtgat taccttcggc ggagcactag cgccatttgc 685261 gattctgttc tcattgccgt tcacagtcat cggtgccctg gtcggacttt acgtatcagg 685321 tgaaacgatc agtctgaacg ccatgatcgg tatgctcatg ctgatcggta tcgttgtcac 685381 gaatgccatt gtcttaattg accgcgtgat tcataaggaa gcggaaggcc tgtctacgag 685441 agaagcgctc ctggaagccg gctctacacg actccgtccg atcctgatga cagccattgc 685501 gacaatcggc gccttgattc cattagccct cggcttcgaa ggcggaagcc aggtcatttc 685561 aaaaggactc ggcgtaacgg ttatcggcgg tttaatcagt tcaacgcttc tgacgctcct 685621 gatcgtgcca atcgtatatg aagtattggc gaagttccgc aagaaaaaac cgggaacgga 685681 agaagagtaa aaaacaaaaa gcctcagctc tgctgaggct ttcagcttgt tgaaaaaccc 685741 tcgcattcgt tgtcaggtct gcgcgtcggt gctcacgaat tctacattcg ctccgctcca 685801 atgctccccc ttcctagact acaagggttt tcaatcaagc tgaaagaatg ttaaggatga 685861 caaaagctca aaacaagaat cagttttgag cttttgtgcg ttttcacctg taagattatg 685921 tacattttgt tgcgattttt ttaactcata gtataattaa aggttgttag tgtaaaaatg 685981 gatcggatac tcttaagtag gatgatgaga taatgaaacg tgcacgcata atatacaatc 686041 cgacttcagg acgggagatc tttaaaaagc atcttgccca ggtcctgcaa aaatttgaac 686101 aagccggcta tgaaacctcc acccatgcga cgacatgcgc aggagacgct acacacgctg 686161 ccaaggaagc ggcattgcgt gagtttgacc tgatcattgc ggcaggcgga gacggaacga 686221 tcaacgaggt cgtcaacggg cttgcgcctt tagacaatcg tccgacactc ggtgtgattc 686281 ctgtcggcac aacgaacgac ttcgccagag cgctcggaat cccacgcgag gatattttaa 686341 aagcggcaga tacggtcatt aacggcgttg cccgcccgat tgatatcgga caggtcaacg 686401 gccagtattt tatcaatatc gccggcggag gccgtctgac ggagctgacg tacgacgtgc 686461 caagcaaact gaaaacaatg ctcggccagc ttgcttatta tttaaaagga atggaaatgc 686521 tgccttcact tcgtccgaca gaagtcgaga ttgaatatga cggcaagctg tttcaaggtg 686581 aaatcatgct gtttttggtc acgctgacaa actccgtcgg cgggttcgaa aagctcgcgc 686641 cggattccag cctgaatgac ggcatgtttg atttgatgat actaaagaaa gcaaaccttg 686701 ctgaatttat cagggtcgcc acgatggcgc ttcgcggaga acacatcaac gaccagcaca 686761 ttatttatac aaaagcgaac cgcgtgaaag tcaatgtatc agaaaagatg cagctgaacc 686821 tggacggcga gtacggcggc atgctgccgg gcgaattcgt gaatctgtac cggcacattc 686881 acgtcgtcat gccgaaggag aaagcggaac agttggatga ctaaaacttg gcttggtaag 686941 ccaagctcag aatgttgaca aaatcctaaa acagttttcg ttttaggatt ttgtcatctt 687001 ttcagcgtga ttgaaaacct ttgaagtcta ggaagggcga gcatcggagc acagcgaatg 687061 ttgaattcgt gagcaccgaa gcacaggcct gacaacgaat gcgaaggttt gcctacacgc 687121 tgaaacttgg cttgaatagg ccaagttttt ctttcgctta aaactagagg tgattataga 687181 tgaaaatgaa acccccagta gaaaaaaatg aatactacga tgtgacattt gaggatttga 687241 cacatgaagg agcgggcgtc gcaaaggtcc aaggcttccc gatctttgtg ccgaatgccc 687301 tacccgagga aaaagcccaa atcaaagtga cacgcgtcaa aaaagggttc gccttcggcc 687361 gcctgattga gctgaaggaa gaaagcccgc atagaacgga cgccccatgc ccgatttaca 687421 aacaatgcgg aggctgccag cttcagcaca tgacctacga aggccagctc ctgtttaaac 687481 agaaacaagt caaagacgtc ttagaacgca tcggcaagct ggacctttca aaagtcaccg 687541 tgcacccgac actcggcatg gaagacccgt ggaactacag aaacaaagca caggtgccgg 687601 taggagaacg ggaaggcgga ctcgtcgcgg gattctatca gcaaagaagc catgacatca 687661 tcgacatgag cgcctgcctg atccagcaat ccaaaaacga cgaagccgtt caagctgtca 687721 aagacatttg cgcaaactac ggtgtcaaag cctacaacga agaacgccac aaaggctggc 687781 tccgccacat catggtcaga tacggcgttg ttacgggcga aatgatgatc gtcttcatca 687841 caagaacaag cgacttcccg cacaaagcga agatcatcga agacatcaca gcgcaattcc 687901 cgcacgtcaa atccatcgtg caaaacatca acccaaacaa aacaaacgtc atttttggca 687961 acgaaacaaa cgtcatctgg ggcgaagaat acatctacga cctcatcgga gacgtcaaat 688021 tcgccatctc cgccagatcg ttttatcagg tcaacccaga gcaaacaaaa gtgctctacg 688081 acaaagcgct tgagtacgct gagcttcaag gggaagaaac cgtcatcgac gcttactgcg 688141 gcatcggaac gatttctctc ttcctggcaa agcaggcgaa aaaagtgtac ggtgtagaga 688201 ttgtgccgga agcaattgag gacgcgaagc gaaacgccga attaaacggc aacacaaacg 688261 cagagtttgc tgttggagaa gcggaaaccg tgattccaaa gtggtacgaa gaaggcatta 688321 cagctgatac gctggtcgtc gacccgccaa gaaaaggctg cgacgaagcc ctcctgcgga 688381 caattgtgga gatgaagccg aagcgggtag tgtatgtgtc ctgtaatcct ggcacgcttg 688441 cgagagattt gcgggtgctt gaggatggcg ggtacgtgac gcgcgaagtg cagcctgtgg 688501 atatgtttcc gcatacgaat catgtggagt gctgtgtgtt gataaaatta aaagaataaa 688561 tagtcaaaaa tctatgctga tggaactgtt ggttctctaa aacgataatt gatttcaatg 688621 gttccatttg catgtacttc tatttcatct actaacaaat gaagcatttc gggggtaagt 688681 gtaccttcct tcatgaattt atctaagctc tttttaaaat caattatttc tttttcaatc 688741 ttttgaaatt ctaggtcctt agatagttgg tgaagggtag tttcaaaatt tgaaatatct 688801 tcattggtga tatttatggc taattggtaa tcttctttag atataacacc attagcaaga 688861 gagataacta aattggattt atctctcttt ttatcgttta atttttcatt aatttcgatt 688921 atcttagatt cgattttttc tttgtacttt aacgcttttt cacttaattc tttaaaataa 688981 ttttccttac tgaatttcaa atatatctta tttaggttgg ttattacttt atcagttaaa 689041 tctatttcac ttacgtaatg atcactacat gcttttaaac catgtttatt ataacttcca 689101 caaacataac cttttcgatt ctttttaaaa tgcattgacc tcctgcaatc tttgcaaacc 689161 gcagtatttg taaagagatg tacttcagct tgaggtctcc ttctttttct agttattaaa 689221 atctcttgta caataagaaa gtcttctaaa ggtatgattg gttcgtggct tttttcaata 689281 attatttggt tttctaggtt aactgacctt cttcttttac tggtaacact cggtctatat 689341 tctctacatt gttgtagtgt cccagtatag tgaggatttt cgagaatttt tcttattgaa 689401 gatccgtgcc atttgtcagt agcgttcttt ttgcgggcaa gctgcgaggg actagtgacc 689461 ccttcgttat acaatcccct tgctattgca tcaaagcctt ttccagcaat atattctgaa 689521 aagattctaa tatttactat tttctctgcg tttgctgaat ttgagagaga tatgattgta 689581 gaacgaactc aagaaggtaa aatgttggcc aagcagaatc cggatttccg agaaggaaga 689641 cccaaaaagt tcacaaagca gcaaatcaat catgcattaa cattactaga aaatcattcg 689701 tataaacaag ttgaagatat gactgggata tcagtttcta cacttgtaag agctaaaaag 689761 aagaaagctg ctgaagctat aaatggataa atattgtgaa ttaattattc aatatcttga 689821 gaaattttta taaaagtaat caaaagttta atgggggaaa cgaaatggcg ctcattgatt 689881 tagaagataa aattgctgaa atagtgaatc gagaagatca ttcagatttc ttgtatgaat 689941 tactcggtgt atatgatgtt ccacgagcta caattacgcg cttgaaaaaa ggaaatcaaa 690001 accttacaaa acgggttggt gaagtacact taaagaataa ggtgtggttt aaggaggcta 690061 agaaaggaaa gctctttgac gcccttattg atatagaaca acaagttgaa tatctttcag 690121 ctaagccacg atatttatta gttactgact atgatggagt attagcgaaa gatacaaaaa 690181 cattagaggc tcttgatgtt aaatttgaag aacttcctca gtatttcgat ttcttccttg 690241 cttggaaagg tattgagaaa gtagagtttg aaaaggaaaa ccccgctgat attaaagcag 690301 ccgaacgttt tgcacggata tatgatgtac ttcgtaaaga aaacaatatt attgagacta 690361 atagagggtt agatttattt cttattcgtt tactgttttg ttttttcgca gaagatactg 690421 acatcttcaa acgaaatagt tttacgaatt taattaagac tttgactgaa gaagatggtt 690481 caaatctaaa taaattattt gctgatttat ttatcgtgtt agataaaaat gaacgagacg 690541 atgttccatc ttatttaaaa gagtttccgt atgtaaatgg ccagttgttt actgaaccac 690601 atacagagtt ggaattttct gccaaatcca gaaagttaat tattgagtgc ggtgaattat 690661 taaactgggc taaaatcaat cctgatatct ttggttcaat gattcaagct gttgcttctg 690721 aagaaagccg tagttattta ggtatgcact acacaagtgt ccccaatata atgaaggtta 690781 ttaaaccgct tttcctagat aaacttaatc agtctttttt agatgcatac gatgattata 690841 caaaacttga aaatcttcta acacgaatcg gcaaaattaa attctttgat cctgcatgtg 690901 gttcagggaa ctttttgatt attacctaca aagaattacg gcgtatggaa atcaatatta 690961 taaaacgact tcaagaactc ttgggagagt atctttatgt accttcagta actttatctc 691021 aattttacgg aatagagatt gaagattttg cacatgacgt tgcaaaatta tcactttgga 691081 ttgctgaaca tcaaatgaat gaagaattaa aaaatgaagt tcataatgca gtacgcccaa 691141 cgttaccact tcatacagca ggggatattc gttgtgcaaa tgctattagg gttgagtgga 691201 ctgaggtttg tcccgcacaa ggatctgaag aagtatatgt ttttggtaat ccaccgtatc 691261 ttggttcaaa aaaacaaaac aaagaacata aatctgatat gttatcaatt tttggaaaag 691321 tcaagaatgg taaaatgctt gattatattt ctgcttggtt ttactttggt gctaaatacg 691381 cttcaactac aaatgcaaaa gttgcctttg tatcaacaaa ttcagttact caaggggaac 691441 aggtttctat cttatggaat gagttattca agtttggaat tcaaatcaat tttgcctata 691501 aatcttttaa atgggcgaat aatgctaaaa ataatgctgc ggtaattgtt gtgattgtag 691561 gttttggccc gttagatacc aaagtaaaca agtatttatt tgttgatgaa acgaaaaagc 691621 tagtttctaa cattagtccc tatttaactg atggtgaaaa tattcttgtt tcttctagga 691681 cgaagccaat ttcagactta cccaaactgc attttgggaa catgcctaat gatggcggag 691741 gattactctt taccattacg gaatatacag acgcaatcaa taagtatcct gaattagttc 691801 cctattttaa aaagtttata ggttcagtag agtttattaa tggtggttta cggtattgtt 691861 tatggcttaa tgaagcaaaa tatgaaaaaa taaagtctaa tcctctaata caagaaagaa 691921 tctcaatttc aaaaaatcac agggaaaaat caacagataa aggaacgaat aaacttgcat 691981 taactccgtg gaagtttaga gatactcatg aaacaactaa ttattccatt gttgttccat 692041 ctgtgtcttc tgaaaataga ttttatattc caatgggatt agcaggtgca gatacaattt 692101 tgtcaaatct aatttatgta atttacgatg cagaaattta ccttctaggc attttgatgt 692161 cacggatgca tatgacttgg gtaaaagctg tagccggaag attaaaaact gactataggt 692221 actctgcagg tttatgttat aacactttcc ctattcctga attatcaaca agaaggaaga 692281 atgaaattga agaagcaatt cttgaaattc ttgatcttcg tgaagagcag ggtggtacat 692341 tagcagagct ttataaccct tcaacaatgc caattgaatt aaaagtagca catgaaaagt 692401 tggatggaat tgtagaaaga gcgtatcgtc aaaaacaatt tgaatctgat gaagaacgct 692461 tagaagtatt gcttaaattg tatcaagaaa tgacagaacg gtaggtgtaa ggtgtatgga 692521 aaatataatt gaaattaatt ataaccaaac tggtaaaagt aagaaaacaa atgaatacgg 692581 tatgcgtgaa atgcaggcaa gagcttttga aaaacgtaac tcacaatatc tcttagttaa 692641 agcaccgcca gcttctggga aatctagagc tttaatgttt atcggtttgg ataagctcat 692701 aaatcaaggt ttgaggaaag tgattgttgc tgtacctgaa cgctctatag gttcttcatt 692761 taaaaatacg gatttaaaaa gttatggttt ctttgaaaat tggaaagttg atcctagaaa 692821 taatttaact gttggcggag ataactctaa ggttaaatct tttgttcgtt ttatggaatc 692881 ggacgatcag gtgttaatat gtacgcactc tactttgcga tttgcgtttg aaaaaattga 692941 tgataaagca tttgataatt gtttacttgc aatagatgaa tttcaccatg tatcggcaga 693001 tgtcaattct cgattaggtg aattgttaag aagtattatt cataattcat cagcacatat 693061 tgtagcgatg actgggtcgt atttccgtgg agattctgta ccaattttat taccagaaga 693121 tgaggaatta tttgacaagg taacttattc ctattatgaa caacttgatg gatatgaata 693181 tctaaaggga tttggtatag gatatcactt ctatcaaggc cagtacacat cagctattaa 693241 tgaagtattg gatacaaata agaaaacaat cgttcatatt ccaaatgtaa actcagggga 693301 atcgacaaag gataagtacg atgaagttgg taagatactt gatatgattg gtgaagttga 693361 atatcaagat gatgatactg gaattattta tgttaagcga cattctgacg gtaaaacatt 693421 gaaaattgca gatttagtag atgaccaagt tggaagagaa aatgtcgttg cgtatttgcg 693481 taatattgaa gccctagacg atttagatat aattattgct cttggtatgg cgaaagaggg 693541 ctttgactgg ccgttttgtg aacatacttt gacagttggt tatcgtggct cacttacaga 693601 aatagtacaa ataattgggc gctgtacacg tgatagttac aataaaacct atgctcaatt 693661 taccaaccta atcgcaatgc ctgatgcaaa ggatgaagta gtgacttata cagtgaatac 693721 aatgcttaaa gctatttctg cctcactttt gatggagcag gtccttacac ctgactttaa 693781 atttaaacgt agaagaaatg aaagtgaaaa atcttctact acaggagaat tattcgttaa 693841 gggattgaaa gaaccatcaa cagaaaatgt caaaaagatt attgaaaatg atattaatga 693901 tttaaaagca aaaatcatgc aagattcaca agtccaaaaa acatttagtg gagaagtaga 693961 tcccaaagta ttgaacaaag tgttgattcc gaaagttatt caaaaagtat atccaaattt 694021 atcagatgag gaaattgagg aagttagaca gcacgttgtt ctagatacag ttatgaaagg 694081 tgctaagtct gaagttgtag gaagtaaaga atttataaga atggcagata agtttataaa 694141 cattgaggat ttagatatca atctgattga ttccatcaat ccgttccaaa aagcatttga 694201 ggttctatcg aaagaattga actcaccagt gctaaaactg attcaggaaa ctattgatgc 694261 aaaacgtatt aattttgatg aagatgaact agtattcata tggccaaagg tttaggaatt 694321 ttatcgttca actggtagaa gacctgattc aaaatctgaa gacccacttg aaaggcgtat 694381 gggtgaagct gtattataca tgcaagagct taggaggaaa cgtgaaaatg gcaagtaata 694441 gataccattc tattaatgaa atcatggaaa gtcagctgtt ttaccaaatc acaacaccac 694501 ctaagaaaac acaaaaagcc cagtatgatc ctgaagttga aaagtttttg gagattattg 694561 aattcgtcaa agaaaatggg cgagaacccc aaaaagtccc tactgattta actgaaagaa 694621 gtttagcaag tcgattaatt gggattcgga aagatcctga tcgtatggaa tatttgaaag 694681 agtatgatga aattggatta cttgaagtaa gatcgaagga actaacaatt cctaaaattt 694741 cttcaattga tgatattcta aaaagtggct tatctgcatt attaggtgat aatttaaata 694801 atgatataac taggtcaatt tttgatacaa gttcacttca aaaggttacg acaatgcctg 694861 aatacgttgc aaagcgtaaa aaaataaaag attttggaaa gtttgaagag ctattcaaga 694921 agtgccacaa ggaaattaca gagggtaaac gaaaaatttt aactttcaaa aatgaacaag 694981 acatacagtc aaatagtttt tatatattaa aaggagttct tctttatgtt gaagatgtgg 695041 gagaacgtaa aaaagcaaag ggaaaaacca atgctagact tcgatgtata tttgaaaatg 695101 gaacggaatc agatatgtta ctacgttcct tatcagcgga gttatataaa catggtagac 695161 gtgtgaccga caatgaagat acattgttgg ataatgttag agaagatgat gtttcgactg 695221 gctttattta cgtactaaaa tctttgagta cagatccgca aattagttcc attaagaatt 695281 tatataagat cggttttaca actggttcag tagaaaatag aatcaggaat gcagaaaatc 695341 aatcaactta tctttatgct ccagtagaaa ttgtaaccac atatcaagtg ttcaatatga 695401 atgctagcaa atttgagacg gcaatccatc atgcgctagc aaataataat ttggatgttt 695461 ctattttggg ggcaaatgga aagatgttag ttcctaaaga gtggttcgtt gtcacacttg 695521 aagatttaca agctgtaata gatgagattg tgatgatggt tcatctttat gactaaatta 695581 gtatattagg attttagtat taataataat tttatagtag actatgaaaa aatttgatgc 695641 cataacaata acttgttccg ctttggagtt tgtcacaatt gtagaattat gtgttgcgag 695701 tattaatagg aaggggttga gcgaccgcaa aaaaaatttt cggtgctgtc cgcaaaaggg 695761 agtttgggtg ttttgcgtta tatttggttg tgtgaaggtt agcggaaact caattcgtga 695821 agttaggatt gcggttatta cgactgagta gtttcgtcat actcttttag cagtttttct 695881 gtcttatgca tttctttgag catcggattc atgtagtcgt tagctgattc tagatatgct 695941 ctcgtcagag tgtctagttt atttctaact ttagagaggt cttcttcgaa ttttccatcc 696001 gatgattgaa ggataaattc ttttgcctct tcatatcttt ttaatatgtt tttcaccatt 696061 ggagttggat tcttttgatt tattgttttt attacagtga ttgttaaatt tatttgtttt 696121 attaattctt ttcttactgt caaggtgatg ctccttttaa atctctattc tatttgagag 696181 ttgctatatc tgtttaatgg tttgatagac tactcatctt tataatttag agcaattttt 696241 acaacttgtt ccgctgtgta atcttcattg ctccagaaaa ttaaatcact tggtgccgga 696301 taaggaacat ttttctctaa taaatcgaga tattcactga ctttctcatc atctaatgtt 696361 gggttcatta attcctttac aagaaagatc aactcttctt ttgtcagttt atccattgtt 696421 tgccctccaa tagattgtat ctccattgat tttacaaatg actttatttc ttctgataat 696481 gttataggtt gtttgcataa tgatagataa ttgtcttgag aaaagttagt ctcattatag 696541 agtttattaa ttgtatttat aacaatatat tcatatggaa aacctctaaa atatctttat 696601 tttagattgg tttataaaaa atagctcagc agagtagggc tgagccattt tttaattata 696661 gaccgaggta actaattaca aattctttat catcctcatc ttcaggcaaa ataccaaggt 696721 ttttatattc ccatattgcg attctttcat atccatctaa ttctgaggct aaaatatcat 696781 cataattata atctaattgg aattctccgc tacgatccaa tgttagtgta aggttagtcc 696841 aaacatcatc gttattattt ctgtgttcag ttcttaattc ttcaaaaagt tctcttagtt 696901 ctcttaacaa cgtcttgaaa atatccttgc ttacgttgta atggctaggt atatcttgtg 696961 aataaataat ttgattattt tctggtgttc tgaaatgaaa aagaaccatt gtggaatcat 697021 ctaatacttc tgcataaaga tatatctttg tccattcacc aggtatgatg tcattgagtt 697081 tttctccaat aagttgatac aaatcttgca tcttcctagt ttccattctt ctaaccccca 697141 ggctgatttt taatagagac gcttatttct tttctgctcc caattttgta ggttacatcg 697201 aaatatgatg gtctaagtga atccccagaa tagactggtt ctatttgaac tgctactttt 697261 ttaggtggtt ttttgcttag ggcttttgcc cactcctgct ccatctcata ccatttccca 697321 ccgctcctat taatctgaga attcatcggc acgatattgt caaactggcc tgagcctttg 697381 aattgggtgg cgattaaatg gccgccgtca tcgtcaggct ttcggtcctg gggctttcca 697441 gcattcgttt gtgcatattg gtttcgtttc gcttctccca gctgcaagtc tgctttgaca 697501 cttgtaattc taccatagtt gtcagtcgtg tacgtgtagc cttcttttgt tttgtagatg 697561 atattaggct tcagcacttt ctttctgctc catcttgcga aatgctcgcc gtatttgacg 697621 gttaccggcg gtacatgtgg cgctggagtt cgtcttccgc ttgatgacgt tccgtatggt 697681 ttcggcagga tgaccttggc gaatttttgc agtccttctt taagcgtgac cccgttgact 697741 gcgttgtaag gaacgcctgc cggcactaaa tcatgacggg gatgatacgg gagaatatcc 697801 gcaagtgtga gatctccgat ttgatttaac ttggttttga cgtgtttttt tgatacttca 697861 atgcctgtgt ttactttttg tttgatgtga tcaacggttt gttttgagac tgttatggct 697921 ttttgggctg ttgctgattt gcttgctgct gttttgactt tggtcgtcac tttggcggct 697981 gtgccagttt ttgagacggc tcctacgcct tttgtgccga caattgatgt gacaacagtg 698041 ccaaccgcat atgacaccca tcttgctctt gagtaggtgt caccattcac catgtctttt 698101 tgatacgatt cttcgattgc cgctgaaatg gcttcatacg ttttgatcgg gtgagccatc 698161 gctccggtaa tcgcttcaac ggttcctccc ggatctgtga ccatatccca caggcctacg 698221 accgcgtctt tcccggaatc ataaaggccg acggcaaccc ctttgaagcc tgcttcaagc 698281 tcacgcgtgt tttcaatttg ggtgaagtat ctctgttgtt cagctgtcag attttcatag 698341 ccgatcgttt ttgccatttc gtagaattca tcggcatctg cataatcgta gtttttcagt 698401 ctttctttca gtttctcaat ctcgcgttcc ttcgcttcct ctttcttaat cttcaagtaa 698461 gcctcagtcc gcttttcaat gtcgcctttt ttcttatgta tgtcactctc acggtacgcc 698521 ttggcgttgt agtggatggg tgtggcgttt ttgcctttac ccgttgcttc ttggagcttt 698581 tggaagtcgg atttgatgaa ttgttcgttt ggttcagaca gggcgtattc tgttttcagg 698641 tcttcgtcca aggcgtccaa tttttccagt gtttttttgc gtttgtcgtt ggcatcggcc 698701 agctcgtctt tgaaggtttc tgttgaaaac aggtcgagcg ggaggatgtc gtcgatatcg 698761 tttaggatgt ctttcatcgc ttttttctgt tcggacatga tggatttaga ttttttattg 698821 gcatttgcca gttcgtgctc caggaaggat tcttcgatgt atgcgtctga gaggcctttg 698881 tcttcggcgg ctccggcgat gctgttgaaa aatgcgattt tcatgtcgat gtagtcgatc 698941 cactggtcgg cgacgccgac gtggtcgtga tagaatgcct tgatgttgct ggcgcctttt 699001 cctgagaatt cactgtcact gagatcagcg actcctttta acgcttttct caagttgacc 699061 atttgcgttc ttagttcttt gtactctttt gcacggtctg tcgcttccga aagcagtgtt 699121 ttcgcttcaa atactttcat gaccatttcc cttcttttgt tcgctcaata tcaaaatttt 699181 accacgggtc gggataaggt gggggtgaga acgtgttttg gtggaaaaat gagtcatttg 699241 gcatgtgtct ttattcgtgg agggattgga ggaaacatgg tcgaaatgat attgattgct 699301 acacattttt tggaagtttg tattctatat tgttttttaa ggagcatgtt gatgacgaaa 699361 aaacggatta catttggttt attagtttta atggtatgtg tcatcctgtt tgttctgtat 699421 gttcagttac gcaataaaga tagtattcct gtccaatctt ccgccattca ccccgaagaa 699481 gaccgcatct tttttattta ctccaatcct ttcataaaag aaagcgtgct gctttcaacc 699541 tctacaggcg aacggtttaa caggcgtacg tttaaggtgg cggatgtgcc ttatattcaa 699601 acgaaatctt atgcatcaac agaccttgta ttattggcgg aacacgagcc tttttactac 699661 acgctggaga aggatgtgat caaagagcat ccgctgtcag atccatttgc gttttggtat 699721 gaggggaagg atgtcactat tgaggcctat aatgttgata cgacgggaaa tgagatccac 699781 ataaacgaca gaaaaacgaa aaaggaatat acccttacct tgcctccgct tgtcacaatg 699841 ggggccagtg atgagaactt tatttatatc attcaaagca tgtctattta cgtgattgac 699901 agaaaaacag aggaaatgat tgagaccctg agcttagcct catacgctga tcaattcgca 699961 gactcggagg aatttatcgt cgcgagctcg gatcataaat tgactgtgat tgaaaaaggg 700021 acatggaaga cgacatatat tgcgtatcct gaagatcttg aatatgcaga tactgtgtac 700081 tatgacaaag aaagcggcag tttttacgtg gcgtacgagg acaaagaggg tggagcgaac 700141 ttgctggaat atggggagga tttttctatt cacacataca gcttgaaatt cccttatatg 700201 gaggcgaagt ttaaggggaa tctattgtat atagttgccc aggaagagca taaaaagggc 700261 atcggcggat acgtgggtgt gtttgatatc cattctaagg agatgcttta tcagtttgat 700321 ttgcctgagg aacaggtgaa ggttcaggat tttgttgtgg ttgacaataa gtgaatacta 700381 tatgaaatag aatgacaaag acccttgcat aaagggttct tttttatgaa aaaaacaaat 700441 tgacaggatg aaaaaacaat ttcttccttc tatattgttt tcaaaatttg ggattgatag 700501 aatatgacat atctcataga gaaggaggga agccgttgag tcaagccata ccgtcttcgc 700561 gtgttggtgt taagattaat gaatggtata aaatgattcg ccagttcagt gttccggatg 700621 ctgagattct gaaagcggag gttgagcagg acattcagca gatggaagaa gatcaggatt 700681 tactgatcta ttattctctg atgtgttttc ggcaccagct gatgcttgat tatttggagc 700741 cgggaaaaac atacgggaat cgccctacag tgacagagct tcttgaaacg atcgagaccc 700801 ctcagaaaaa actcacaggt cttttgaaat actactcttt gtttttccgc ggcatgtatg 700861 aatttgacca aaaagaatat gtggaagcga tcggatatta tcgcgaggcg gagaaagaac 700921 tgccgtttgt gtcagatgat attgagaaag cggaattcca ttttaaagtg gcagaagcgt 700981 attatcacat gaagcaaacc catgtgtcga tgtatcatat tcttcaagcc ttggacattt 701041 atcaaaacca tcctctatac agcattagaa cgatacaaag cttgtttgtg atcgccggca 701101 actatgatga tttcaaacat tatgataaag cgctcccgca tttagaggcg gcgctggaat 701161 tggcaatgga cattcaaaat gacaggttta tcgccatttc tctattgaac attgcaaaca 701221 gctatgacag atcaggagac gatcagatgg ctgtagaaca tttccaaaaa gcggcgaaag 701281 taagcagaga gaaagtgcct gatctgcttc cgaaagtctt gtttggatta agctggacat 701341 tatgtaaagc gggccaaaca cagaaggcgt ttcagttcat agaggaagga ttagaccata 701401 tcacagcacg ttctcacaaa ttttataaag aattgtttct gttcttgcag gccgtgtaca 701461 aggagactgt tgatgaacga aaaattcatg atcttttaag ctatttcgaa aaaaagaacc 701521 tgcacgctta cattgaagca tgtgcccgga gtgctgccgc tgtttttgaa agcagctgtc 701581 actttgaaca agcagctgcg ttttatcgga aagtgctgaa agcccaagaa gatattctaa 701641 aaggagagtg tttatatgcc tattaagaaa aaagtgatga tgtgtctggc tgttactcta 701701 gttttcggaa gcatgtcgtt tccaaccctg acaaactccg gtggatttaa ggaatcgaca 701761 gatcgaaata cgacgtatat cgatcattcc ccttacaaac ttagtgatca gaagaaagcc 701821 cttagctagg gctttttctt gctttacgga agacgttcca ttttccacat cgcggcattc 701881 cttctatttc taacgcaaga cactcgaaac aaccaaacca tttgaggtat aatggataaa 701941 gtgaataaca gtatttagat tgatatatat gaaagagagt ggaacatcat gggccgtaag 702001 tggaacaata ttaaagagaa gaaggcgtct aaggacgcaa atacgagtcg gatttatgcg 702061 aagtttggcc gtgagattta tgtggcggcg aaacagggcg agcctgatcc ggaatccaac 702121 caggcgctga aggttgtgct tgaacgtgcg aagacttaca gcgtgccgaa aaacatcatt 702181 gaacgtgcga tcgagaaggc gaagggcgga gcggaagaga attacgatga gcttcgttat 702241 gagggcttcg ggccgaacgg atcaatgatt atcgttgatg cgctgacgaa taatgtaaac 702301 cgtacggcgc cggaagtgcg tgcggcgttc gggaaaaacg gcggaaacat gggtgtgagc 702361 ggatctgttg cttacatgtt tgacgcgacg gctgtaatcg gtgtggaagg caaaacggct 702421 gacgaagcgc ttgaaatcct gatggaagcg gatgttgatg tacgtgacat tttagaagag 702481 gatgacagcg cgatcgtgta tgccgagcct gatcaattcc atgcggtgca agaggcgttt 702541 aaaaacgcgg gtgtcgagga atttacagta gcggagctga caatgcttgc gcaaagtgaa 702601 gtaacgcttc cggatgatgc aaaggaacag tttgaaaaat tgattgatgc attagaagat 702661 ttggaagatg ttcagcaggt atatcataac gttgatttag gtgagtaagg agtgagcagg 702721 ctgttatggc ctgctttttt tgtcccggaa attgttttag ctgtatgtag gcggccgcct 702781 atacgatcta taagatattc tcatactctg gactgtaacc tatgtgaagg agagagtaaa 702841 tatgactgat acaagacata tgtatggcgg acctggtttt ggtcattatc agggctttgg 702901 tattggccac ccgggctatg gcatgcaaag cacaggctat ccgggctatg gcatgtatgg 702961 aggccacccg ggctatggca tgcaaggcta cccagatcac ggcatacatg gaggagtcgg 703021 cggctatccg ggatatggtg ggtacggcgg ttacccaagc ggcggctatg gaggctctcc 703081 gggaactgga agctatccga gcatgcacca tgaaaatgat ggccatcacc actattatca 703141 ccatcatcat gatggaaaag ataatcttca tcaccatcat caccatgttg gaaaggataa 703201 tcatcaccac catcatgatg gtcattatgg ccaccatcat caccatatgg gccactgggg 703261 aaaagacggt tataaataaa gaagatgatg ataaaaagag gacactcttg cagatcaaga 703321 gtgttttttt agcttttttc ttgactgttc agtctggaaa atggtaacat ttgtttcagg 703381 aggtgatcat tttttgggga ggaataaaga atttgatacg gcgcttgttc ttcacagggc 703441 gatagaggtt tttggagagt atggctacga aggaacgtct cttcaggatc tgctctctca 703501 tttaggcatt gcgcgccaaa gtttgtatga tacgtatgga acgaagcgtg atttgttttt 703561 gtccgctgtg aaatcgtatc ttgaagggaa aaacgctgcc gttatggaaa ggcttgaagc 703621 gccaggatct gtaaaggaag ccattcgtga tatttttcag gagggtgtca atgccctgag 703681 ggatccggaa cgggcgaagg cgtgctacat tattaacagc gcgattgaac agatcccgca 703741 tgaccctgag cttgcccggt attttgaaag acaatccaag cagcttgagg acgcttttta 703801 tcacgggctt ttaagagcga aggatcaagg agaattgaat ggcgaagata ctgatatatc 703861 tgcgcttgct cggtacctga atcagagcag gctgtcactg acatttattg caaaagtgac 703921 ggcagatatg gatcggcttc aggaccatgt tgacgtgagt ttatcagtgc ttgattaaca 703981 tgtggtaaag gattctttgc ccatgtatgt actttttgga ctgaatagtc tagaaataaa 704041 aatgaggtga tgatgaatgt tgatgaatga gtttgaaaaa gcatgtgaaa cattgagaaa 704101 gtttatggct tatatgcttg agaaggacat gaagagctgg acggagcttt gggatgagaa 704161 tgctgtattt gagtttcctt atgcgccgga gggatcacca aaaagaatag aaggaaaagc 704221 ggccatttac gattatatta aagattatcc taagcagatt catctttctt catttaccgc 704281 tccgacagtg taccgttcag cagactcgaa tacggtgatt gcggagtttc aatgtgacgg 704341 ccatgtgatt gagactggac tgccttatcg ccaaagctat atcagtgtca tcgaaacgag 704401 agacggccgc attgtgcgtt atagggatta ttggaatccg cttgttgtaa aagaggcctt 704461 tggaggatca tttttgcaaa cagaggagag tgggaaatga tgaaacagaa tccgatttta 704521 atcacgggcg ggaccggcac agtcggcagc cgaatcgcca gccgtttaat aaagctggga 704581 tacagagtgc gtattgcaag ccggaaaaag ggcgcgcttg ctgatgctga gtatgtgtat 704641 tttaattgga agtacgcctc cagttttacg cctgctctgg aacaggtaaa acagatctat 704701 cttgttgctc cggtcggtgt atttgatccg gctccctatg tgcttccctt tttaaaggaa 704761 gcaaagcgtc tcggcgcaaa gcgggtagtg atgcaaagtg cgtctgttgt ctccgagaac 704821 ggtcccgtgt ttggcgcgct tcaccaggca gtgcgcgagt ttccagaatg gacggtgctg 704881 cggccctcat actttatgca aaatttcatc aatgtccagc accgcatgtc tattcaaacg 704941 gaggggcgca tcacaacggc ttcgggtgaa ggaaaacttg ggtttattga cgctgatgac 705001 atcgcagaaa cagccgtcag ggctttgatt gatgatgttc ctcatcaaac acatcatatt 705061 ctgacaggtc ccgaggcgct gagctatgcc gaagcggcgg agatcattgg agctgcggcg 705121 ggacgccggg tggagcatgt cagcatttct cgttccgagc tgcagcataa aatggaggca 705181 ggaggtttgc ccgcggatta tgcccatttt atggcgaagc ttgatgaggc aattagccat 705241 ggtgcggaac atcgggtaac ggatacagtg aagcgtgtga cgggaaaaga acctcgttcg 705301 ctgtcagagt ttgcggctgc tcatgctgca tattggacct cattttggac tgaatagtct 705361 agaaagacct tcggcgcttc cgaaggtctt cttattgaaa aagctaagtc gtgttttagt 705421 cataatcatg cctcctgcct catacctatt aaggtcattg tttttgagaa aggaggagcc 705481 ggaatgaagg atatgcagcc gtttacgcct gtcaaatcat atacgccctt tcacagccgt 705541 tttgatccct gtccgcccat agggaagaaa tattacagaa cgccccctaa cctttatatg 705601 acctttcagc ctgagcacat ggagcagttt tcgccgatgg aggctttgag gaaaggcacc 705661 ctttggaagg atctctatga tttttatgaa aacccttatc gagggggaga cgcacatggc 705721 aaaaaaggtt gacgccgaat attatcgtca gctagagcaa atacaggctg ctgattttgt 705781 gcttgttgag ctgagtcttt atttaaatac acatcctcat gatgaagatg cgttgaagca 705841 attcaatcaa tattccggct attcaaggca cttaaaaaga cagttcgaat cctcttacgg 705901 accgcttctg cagttcggca acagccccgc gggcaaggat tgggattggg gaaaagggcc 705961 atggccgtgg caagtataag gaggaatgcc tgaatgtggg tgtatgaaaa gaagctgcaa 706021 taccctgtca aggtcagtac gtgcaacccg acgctggcga agtatttgat tgagcagtat 706081 ggcggagcgg acggcgagct ggccgcggct ctccggtatt tgaaccagcg ttatacgatt 706141 cctgataagg tcatcggcct tttaacagat atcggcacgg aggagtttgc ccatttggaa 706201 atgattgcga ccatggtcta taagttaacg aaagacgcca caccggagca gctgcgtgaa 706261 gctgggcttg gcgatcatta cgtcaatcac gacagcgcgc ttttttatca taatgcggcg 706321 ggcgtgccgt ttaccgcgag ctatatccaa gcgaagggcg atccgattgc cgatttatac 706381 gaagatattg ccgcagaaga aaaggcgcgg gcgacgtatc aatggctgat tgatatttcg 706441 gatgatcctg atttaaacga ttccctgcgt tttttgcgtg agcgtgaaat cgtacactct 706501 atgcgcttca gagaagcggt tgaaatttta aaagaagaac gggataaaaa gaagattttc 706561 taataggcag attggcctct ctttcataca cccttttaca tacagagaaa atggtctgtt 706621 tttgcagttt ggtctgcatt ataatcaagg tgtgtgtgca agcttacttt ttgattggga 706681 ggcctttatg acagctttta agattgagaa cgaaacgatt gcagatggat tttacgcgtg 706741 tccggccgtc tatgaggatg cagaatcgat taccgggttg ctcgtccgaa cagctgaatg 706801 gctccgggat cggggttcta accaatggag cggacttctc aaagggcaag atatacatga 706861 tatcacgggg tcaattgaaa agggacatgt gtttgtgttt aaaaaagatg aagagcttgc 706921 ggctgtcgtg atgctgctgc ctgcaccgag cgagtgggac cggacgcttt ggggagacga 706981 tgggcatgag gagtccattt atttacaccg cctcgcagta agccgccggt ttgcgggaca 707041 ggggcttgga gcccgcgtcc ttcagtgggc ggagacgggc atacactttc cggaaaaaac 707101 gcggatccgg cttgactgtg tcgctgatag tgacgccctg cattcctttt atcggcgtat 707161 gggatatgaa ttcatgggtg ctgatgcgtc cggatatcat ttgtttgaga aagagattac 707221 ggcagaataa gcgtcctttg cagggggctt ttttgtcttt ttctaaaagg gaggcaggcg 707281 atgtgtggtc aatattattt gtgacaggga ttgtgacggc ttgtctgttt gctggcgtat 707341 ccgtattgat gcggatgaga tttcctgaca aaagtcggcc ggaatggatg ttggccgggc 707401 tgatcgtcct tggtgtgttt gcgatctggt acagcctcgt gtatgtacgc ggctgggaag 707461 gggctgcgct cggaatgctt ggattcaatg tcattttcgg agccattgcc ggatatttga 707521 tcgataaggc catccggcgt tacaggaaaa gataaggctg ctgccgtctc tcaacaggtc 707581 gaaattttca cagaccggca ggaattttct ttcgaaagga gaaatacata ttactttaaa 707641 atgaaagcgt tttccaaagc aggaaggtga tgttgatgat acacagtgtg gcaaatgggc 707701 tgaatcattt ttgtacgtgg gtgatgagac tggcctattt gaatgtgctt tggattttgt 707761 tttctcttgc aggcctggtt gtatttgggc tgatgcccgc tactgccgcg atgtttacag 707821 tggcgagaga atgggcgaag gggaatacag atgccccggt gttttctgtc ttttttcgga 707881 cgtttaaaaa ggaatggcgg gcatcacaga tcctcgggct tatcgttgtg acggctgccc 707941 tgtttctgtt tgcggatatg cggatagcgg ctcagatgga ccagcctgtg ctcgtcaatg 708001 tattcgtgag cattagtttg attttcgcgt ttgttgtgct gtatgtgttc ccggtatttt 708061 ctcattttga cgtaaaaatc agagaggtgc tgagcatcag ctttttcatt gccttcagtc 708121 gtccggcggt gacgcttttg atggcagcgg gcgctgtcgg tgtgctttgt ctcgttctgt 708181 ttcatgtcac gtttctattg tttttcagcg ggagtttact cagcctgatc ttaacgaagc 708241 tgtcctttaa agcgtttcgg tcaatggatc agcggcagga gaaagaaaag gcggcatgaa 708301 gaaaagagtt gctggctggt acaggcggat gaagattaag gataagctgt ttgtgtttct 708361 atcgttgatt atggccgtat cctttctgtt tgtatacagc ggggtccagt atgcctttca 708421 tgtgtatgat gagcagattt accgcaagtc ctcggaggtg cttcggatgt cttctgaaag 708481 gatcgaagac gagctgaaga agatagagga tgtgtcatat gaaatcatta cagacgaaca 708541 gattcagcgc atcctgagca tgcaaaatcg ggatgatacg tatgatcaat atcaaatgaa 708601 gcaggagctg tgggatcagc ttgcgggata tgccagcgat gaaaagtaca tcgattccat 708661 tcatgtgatt gatgcccgcg gctcagagta ttcagccgga agcagttctt cagatctttt 708721 gcagcaggag caggaagagg tatttaagcg agcgaaagcg aaaagtggaa gaaatctttg 708781 gatgacgctc ggcgggtcag accccgtcct gatttcagca cggcagatca ggtcctatca 708841 ccagctgagt ctgaacggct tgggcatggt actgatccag gtcaatgtaa aacagatgat 708901 tcgtgatgtg ccgaaggatt ggggcgattc agtcggagac attatgattg ctgaccaagg 708961 cggtaatttg gtgtatacgg cacatgcatc agcgcatgtt cctgaggcag caaaagagac 709021 gttgaagcac cccggttatg acttgataaa aaagaatggc aaacgttact ttatttctta 709081 tcttcaatca tcctaccaaa attggagcta ctataacgtt atcccctttg atcagatgtt 709141 cgcaaaaatt tcctttatga aaacagtgat cggcacatgc tttcttctct ttttctgtgt 709201 ggttttgctt ttcggaagga aaatcgccaa cagcatcacg gagccgattg aacagcttgt 709261 gaccgcgatg aaatcggtac agcacagcgg cattgaagca ggtgtgtcgc tttctctgcc 709321 ggaacataca caggatgagg ccggcatgct gaaccgccat tttactgtca tgatgaaacg 709381 gattaatgag ctgatggaag aaaatgtgga aaaacagctc atcattaaag aaaccgaatt 709441 gaaagcactg caagcccaga tcaatccgca ttttttatat aacacgctcg agtccatcaa 709501 ttggctggcc aaggcgaatc agcaaaagca aatctcaaaa atggtggaat cgctcggttt 709561 tcttctgcga aacagcatac atatgaagaa ggatatcgtg accattcagg aggaggcgga 709621 cattgtacgt cactatatga ccattcagcg atttcgattt gaagagcgcc tgaaattcac 709681 gttggatatt gacgatgagg tgaagcattg cctcattccg aaactgacgc tccagccgct 709741 tgcggaaaat gcgattcaat acgcgcttga accctttaca aggccatgcg ccatccggat 709801 tcaggcgaaa aaggcgaagg gctgtgtctg tattacggtc gaagataacg gccctggcat 709861 ggatggacgg attcttgaat caacgggtgg aagaggaatc ggactttgga atattcgcga 709921 gcgcatcagc ctgacattcg gagagccata cggattgcgg attcatagtg agcatgaaaa 709981 ggggacgagg attgtgatca caataccgtg ccgaaatgag gtggtgtgat gtataaaata 710041 ctgctggctg atgatgagag gattatcctt gatggaatgg cgggaatcat tgagtgggag 710101 tcgcttggcg cctcattgat cggaaaagcg cagaacggac atgaagcata tgaaaagatt 710161 gtacataagc agccgcatat cgtcatcaca gacgtcaaaa tgcccggcat ggacgggctt 710221 gagctgatca aaaaggtgtc agccgtcagc ccgtcggtgc aatttatcgt cctgtccggg 710281 tttggagagt ttgagtacgc aaaggaagcc atgaaatatg gggtgaagca ttatttgctg 710341 aaaccctgca atgaacagca gattatcagc tcgctggagg aaatcattgc tgagctgaag 710401 cggcaagatg tgcacaaaaa gaaaacagcc catctgaaac acgagctgga ccatatccgt 710461 tcctttgcag ccgatcaata cttggaaggc ttgatcgccg gtgtggccca gctttctccg 710521 ccgccttcac ttgccggaaa aaagatccgc ctcttgatct taaaagggga acaatctatt 710581 gatgctgcag ccagagaggc actcggatcg gcactgacag cggtttgcag cagcggtgaa 710641 tggaccgtgc tcgccgtaga ggagaacgcc gctgaaaagg tggcggaggt ttttgcggac 710701 cgcaagatgg ccatcagtca ggcgggagaa ctccggcacg cggggcagct gtttcgtgac 710761 acagctgaag cgtctggtga cctgcatggg agcgcagtga tttcaaaaat gatcaggctt 710821 attgccgacg agctcggaaa tccgaatctg tccttaaaat gggcggcgaa ggatatgctg 710881 tttatgaatc ctgattatct cgggaagtta tttaagcagg aaacaggcga gaaattttcc 710941 caatatgtta cacgggtgcg tcttgagcat gcgatgaagc agatgaaaat aaggagggac 711001 gtgagcgttt cagaaattgc tgaagaaatc gggtttggcg ataatccgaa gtatttcagt 711061 cttgttttta aaaaatatac cggtctgaca ccgtcagaat tcagaagaaa acagggaggc 711121 gcttccgcag gatagccatc tctgtttttt tgactttcgc cactgttttt tgagtgtttc 711181 gccctatccg aacgctttaa aataaaatgt aagcacttac attaaagggg ggattggttt 711241 gaagaagatt tgttacgtgc tgttatccct tgtctgcgtc tttttgttca gcggatgttc 711301 agcgggtgaa gaggcctcgg gaaaaaaaga agatgttaca ctcagaatcg cgtggtgggg 711361 cgggcagcca aggcatgatt atacaactaa ggtaattgaa ctatacgaga aaaagaatcc 711421 gcacgtccat attgaagcgg aatttgcgaa ctgggatgac tactggaaaa agcttgcgcc 711481 catgtctgcc gccggccagc ttcctgatgt cattcaaatg gataccgctt acttagccca 711541 atacggaaag aagaaccagc tggaagattt aacgccgtat acaaaggatg gaacgattga 711601 cgtcagttca atcgacgaga atatgctgtc gggcggaaaa atcgacaata agctttatgg 711661 atttacgcta ggtgtcaacg tgctgtctgt gattgccaat gaagatttgc tgaaaaaagc 711721 cggtgtgtct atcaatcagg aaaactggac gtgggaggat tacgagaagc tggcgtatga 711781 tcttcaggaa aaagccggtg tctacggttc caacggaatg catccgcctg atattttctt 711841 cccttattat ttgcgcacaa agggtgagcg cttttataaa gaagacggca ctggcctcgc 711901 gtatcaagat gatcagctgt ttgtcgatta ctttgaacgg cagctgaggc tagtgaaagc 711961 gaaaacgtcc ccaacacctg atgaaagcgc acagattaaa gggatggaag acgattttat 712021 cgtcaaaggc aaatcagcga ttacatggaa ctactccaat caatatttgg gctttgcccg 712081 gctgacagac tcgccgctgt ctctctatct gccgccggag caaatgcagg aaaaggcgct 712141 gacactgaag cccagtatgc tgttttccat tccgaaaagc tctgagcata aaaaagaggc 712201 agcgaaattt attaatttct tcgtgaataa tgaggaagcg aaccagctga ttaaaggcga 712261 gcgaggcgtt ccagtctccg acaaggtggc ggatgcgatt aaaccgaagc tgaatgagga 712321 agaaaccaac atcgtggagt atgtagaaac cgcgtcaaaa aacatcagca aagccgatcc 712381 gccagagcct gtgggaagcg cggaggtcat caagctgctg aaagatacgt cagatcagat 712441 tctgtatcag aaggtatcgc cggaaaaagc cgccaaaacg ttccggaaaa aggccaatga 712501 gatattagag aggaataatt gacgggaaat ggggctgacg caatgaaaaa aagccggagt 712561 ataagaaaag acaatctggc gggatatgct tttatttctc cgtttatcat cgggttccta 712621 tgctttacgg tgattccgat gggggcgtcc ctgtttctgt ccttcacgag ctatgacttg 712681 tttacggcgc cgaaatggat cgggctcgac aactttaagg aaatgtttac gggtgacgaa 712741 aagtattggc agtctctgaa ggtgacgttt acgtatgtgc ttgccggggt tccgctccgc 712801 ctcggcttcg cgctttttat cgctgtcatt ttaaacaatg cagcaaaagg aacggccatt 712861 tacagaacgc tcttttatct gccttcgatc atcggcggga gcgtcgccgt ggcgattatg 712921 tggcgcaata tttttggcaa tgacggggtc atcaatgcgc tgctgttttt tgtcgggatt 712981 gatcaaaaaa ttctttggta ccagaatccg acaagtgcgc tgtggacatt gattctgctg 713041 tccgtctggc agttcgggtc gtcaatgctg atttttttgg ccgggctgaa aaacattccg 713101 tcttcgtatt tggaagcggc aagtgtggat ggggcaaatc gggtgcagcg tttcttcaag 713161 atcacgcttc cgatccttac accgattatt ttctttaacc tagtgatgca gacgatttct 713221 gcttttatga catttacacc tgcctatatc atttcgaagg gcgagggcgg gccgcttgac 713281 gggacacttc tctattcgct ctatttgttc cagcgtgcgt ttaactattt tcaaatgggc 713341 tacgcatcgg cgatggcgtg ggtcatgctt gtcattgtcg ggctgattac gctcatattg 713401 tttaaaacat cgtcatattg ggttcattac gagtcaaagg aggaatgacg gatggagccg 713461 gtcaaccagc ctgtcagaga agccccggtt tttgagagaa aaaaagccgg gcgcgtcagt 713521 cccaaacgca tactgttcca tgtttttacg gcaacgctgg cggtgttgct gctgtacccg 713581 gttatttggc tgtttgtcag ctcgtttaaa gaaagcgcca gtatttttac aacctcacat 713641 tctctcattc cagacccttt tattctcagt aactatgctg aagggtggaa gggcattgcg 713701 ggacagccgt ttctgacgtt tattaaaaac tcggcgatta ttgtcgggct gtcaacaatc 713761 ggtgccgtca tgtcatcggc tgtcattgcg tacggatttg cgcgtatacc gtttaaggga 713821 aaaaaatttt ggtttgcgtg catgatgggg acgttaatgc tgcctcatga agtgttgatg 713881 attccgcagt atattatgtt tgcgaaatta gactggctga attcctttaa accaattgtc 713941 gttccgcaat ttttcgggca tgcgtttttt atctttctga tgatccagtt tatccggacg 714001 attcccgagg agctggatga agccgcgcga atcgacggat gcggacgctt tgcctgcttt 714061 tggcggatca ttctcccgct gattgccccc gcgcttgcga cgtctgcgat tttctccttc 714121 tattggaagt gggaggagct gattcagccg ctcttgtatt tgaataagcc ggagctttac 714181 cctgtttcac ttgcgctgaa gctttttctc gatacagagt cggcttcgaa ctggggcgcg 714241 atgtttgcca tgtcagccgt ctcgttattg cctgtgattc ttgttttctt tttgtttcag 714301 aaatatatcg ttcagggcat cagtacgacc ggattaaaat aaaaaggagt gttgcagatg 714361 gcacagctta tctttgatga agaaaaggtg acgtcggtta ttgaccggat cgtgaaacgg 714421 acatttcaga tggattttgc gtgggattgg ccgggcggcg ttgcgtttta cggtgtggcg 714481 gaggcctatg aagcgacgga aaacgaggaa tatatcaatc tgttaaaaac gtgggtggat 714541 gaacagctgg aggatgggct gccgccgctt tcgatcaacg gagtttccat tgggcatacg 714601 cttttgttcc tccacaaggt gacaggtgat gacgtgtatt tggaaacagc ggccgagatg 714661 gcggaatatg tgctgcataa ggcgccgcgc tttggcgagg gtatccttca gcatacggtg 714721 aatgcggcag aatacgtatt ccctgaacag gcatgggcgg atacgctgat gatggctggg 714781 ctgtttatgc tgagaatcgg gcgggtcatg gagcgtgagg attattttga agacggcctg 714841 cgccagtttc acggacatga ggatgtgctt caggaccctg tcacgaattt gtactaccac 714901 gcctgggaca acaaagcgca aaatcatctg tcggggattt attggggcag ggcgaacggc 714961 tgggcggcac tcacgatggc aaaggcgctc ccgcttattg aggtgacaca tccttccttt 715021 atgatcatcg acggatcgct cagagaccag ctgagcgcgc ttgtccggct tcaggatgaa 715081 tcagggctgt ggcatacaat tttggatgat ccggattctt atctggaggt ttcggcatca 715141 gcgggtattg cttctgctct gatgtcgagc ggaaagctgt atacaaaata tgtgcagaaa 715201 tcgcttgccg ccattttgga tgcagtggaa gaggacggac gggtcagcag ggtatcggcc 715261 gggacagccg tcatgaaaaa tgccgaagga tacaaacagg tgccttacaa acgaatacaa 715321 ggatgggggc agggacttgc gctgacgttt cttgctgatg ttttgaaaac gaaaaaacgc 715381 ttgtatcagt aaagatagcg gcggggggag agggatgaaa aaacagcctc aacagaagga 715441 acgggtttct cgctggaagg gaacgtattt caaaagaaac tttgtcttca ttttgctgat 715501 tgcctgtatt cccggattgc tgactggcgg cgcaatctac tttctttcga tcgacaaggt 715561 ggagaaagag ctgcagagat cgcatgaaac acaggtggcg cgtgaggtca gccgaatgga 715621 tgagaagctg ggagtgcttg aactggcact cacccagatg gcctacgatt cttcactgat 715681 gaacggattg gccgagaggg atttggagaa agactttacg ttctcctatc aattaacgaa 715741 aaagctgttt cttttgcggg atcagcagcc gctgatcgag caggcttcca tctttctgaa 715801 cagcccccgg ccacttgtgc tgagccctga atacagcgct ttgacagaac aggaggcgct 715861 tcgcaagtat cgctcgctgc ttgcctcaga ccacagcatt tattggaaac ggtcgggaaa 715921 ccaagcgatg ctgatccagc tcattccggg cgcggcggag aaaccgttcg gcgcgatcat 715981 gctggcggtt gatccgaaag aaatggaatc aatcctgcaa agcttgtccc cctatcctga 716041 tggcagtgcg ttgcttttag atcaaaatcg agaggtgctg tttcatgagg gggaaaaaga 716101 ttttgaaaag actttacttc atgagataaa aaaacagcct gctgagaacg gccattttca 716161 gatggaatgg aaaggcaagg tgtattctgt ctcctttgga gaaatgaacc ggatgcatca 716221 gcaatggacc tttgtgtcag cggcgcctct ttcagctatt acagcgccga tggtgttttt 716281 atcaaaagtg atcatcgtga tgctggtcat ttgcatcggt ttggcggtgt gcatgacatg 716341 gtatgcatca aaaaaaatct atcgtcccat ccagcatttg cttggcttgt ttaccggagg 716401 agagaagaaa acatggcagg cgtccgggca ggatgaattc aaatggattg aaaagagatg 716461 gcaggatcta tcccttgaaa gccggaagct ccaacagcag ctcctgcggc agacgcccca 716521 tatgaaaaag agttttttgc agcatctctt acagagcgat ttttactatg acaacgagga 716581 aagcctcaga tttcggatgg aggaggctgg ctggaacatc ggcggaaacg tgtttcatgt 716641 gcttgatcta caggtgacag ggctccgctg tgaaaaaagc atcttccgtg aaggtgatga 716701 acagcttgcc gtgtttacac tgactaatat cgctgaggaa ttggcggcta aacgcgtttt 716761 tcagctctcc atacttgata tcggccggct ttctgtcacc gttcttgtga tgaaaacaaa 716821 cagctctgat ctgaaggcgt atataacgga gctggcacgc caatttggag atgtaaccgg 716881 actatgcctg acctcgacat tgagcagcaa gacggagcgt gtcacggaaa ttccttcttt 716941 atttcaggat gtgaaatgcg gcaaatcccg caggaagttt gctaaccggg atcaggtcat 717001 tgatttgcag gccgacttcc ctcgggatga gcagttcgct ccttattacc cttttgagct 717061 ggaaaaacaa attgttcaga ccatccggct ggaaagaaaa caggaagcca aggaactgat 717121 agatggatgt atgaaggaac tgtcggaaaa agcggccata gacaggcatg tgcattccgc 717181 cctgattcag ctgttttccc gcattcagga ggatattttg cattccgggc tcaatcccag 717241 cgaactgttt cagcaccgga atccgtttct tgatatttca gaattgcgcg aacctaacga 717301 agcggcggcc tggctgatgg atgtagtggt gacgccttac ctttccaagc ttgagggcag 717361 aaaaaacaga cagcaaaagc agctggcaga acgtgtgatt gcgatgattc acgaacagta 717421 tatggcggac atttcattgg aaagctgtgc cgatgcgctt ggcatgaatt cctatacgtt 717481 aagcaaggca tttaagcaag tgaccggcat taattttatc gattatgtga cccagatcag 717541 aatcgaaaag gcgaaagaac tgctggtcaa tacgaataaa aaaattcatg atgtgtctga 717601 agaagtcggc tatcgccaca attatttcaa tcggattttt aaaaaacagg tcggcatgcc 717661 gccgggtgtc ttcaggcaaa tgtatcagga aacgccgtga aaggagagaa catgtgatga 717721 agaaaccgat tcaagtattt ttagcggggg attccactgt gagtgactgc ccgcctcatg 717781 aagcgccgat ggcggggtgg gggcaggtat tcgggcaatt gttttctgaa ggtgtgctgg 717841 tccgcaatca tgccaaagga ggagcgagca ccaattcttt tgtggaggaa ggaaggcttc 717901 aagcaattgc cgagcacatc acacaaggcg attatttgtt gattcaattc ggccacaatg 717961 accaaaaacc gcgggggacg aagccgtact ccacatttca gcagtttctt accttgtttg 718021 cagatacggc acgcgaaaag ggcgcgcatc ctgtgttcgt cacatcggtg cagcgccgcc 718081 gctttgatga aaacggacgg atcgagcata cgctcggtga gtatcccgat gcgatgaaag 718141 cactggcgaa ggagctcgat gtacctgtga ttgatctgct tgcgaaaaca aaggtgctgt 718201 atgaagcata cgggccggag gagtcgaagc gattgttcgt ttggtttcag ccgaatgaac 718261 atccgaatta cccggacggc attgaggaca atacgcattt ttcggaaaaa ggtgcaatgg 718321 aggttgcgaa gcttgtggca gaaggcattg aagagctcgg acttccgctt aaggaccacc 718381 ttgtgagccg ggagggaaaa gaacatgtat aaggaaggcg cttgcttgta ccgcaatccg 718441 ctccggtcta aaagcgatgt gaaggattgg cggatggagg gaggcggaca gatctcattt 718501 gacgatcaca gcttgcacct gtcacatgtc caggatgaag cgcactttgt cttttggtgt 718561 ccggaaacct ttccagacgg catcattgtg acatgggact tctctccgat cgagcagcct 718621 ggactgtgta tgctgttttt tgccgctgcg ggtattcgcg gcgaggattt gtttgaccca 718681 agtctcagga aaagaacagg aacataccct gagtatcatt caggagatat caatgccctc 718741 cacctgtcgt atttccgcag aaaatacgcg gaggaaagag cgttccgcac ctgcaattta 718801 agaaaaagcc gcggtttcca tctcgccgca atgggggccg atccgctgcc ttctccagac 718861 gacgctgatt ctccgtatcg tatgaagctg atcaaagaca aaggctatgt gcacttttca 718921 atcaatggtc tgcccattct tgagtggatg gacgacggca gcacatatgg gcctgtgtta 718981 acaaaaggaa aaatcgggtt ccggcagatg gcccccatga aagccgttta cagggatttt 719041 gccgtgcatc aagcggtgag aagatgaaga cgactgtaac ggatgcgctt tatgcaggct 719101 gcgaagcggt ggtgaaaata gcatggctca acgggctgtg gctgttgttt acacttttgg 719161 gcggcgttct tttcggatgg gcgccgagca cagctgcgat gtgtgccgtt ataaggaaat 719221 ggctgatggg gcaaaaggat gtcccgatat tttcgttatt tctcgatacc tataaaaaag 719281 agtttctcaa ggttaatgcg atcggattgg cgttttcggc tcttttgctc atattgtctg 719341 ccaactatca ttatttttct gccagtacga attggctgtc ctttgccgta acaagctgca 719401 cgctgcttgc agggcttttg tatatcatcg cgctgatgta tgtgtttccc ctttatgtgc 719461 attaccagct cccgcttcgc aaatatattc cgcaggcact gctgtttggc gccatgagac 719521 cgctgacaac tggctgtatg ctgatcgggt gcggatttgt cctttatttg ctgtatacgc 719581 ttcctggcct gatcccattt tacggcccgt gtttatttgg gcttgtgttg atgttttttg 719641 ctcttagggg atttcaaaag acggaggccc agcaccatca agccgggtaa caaaaaaatg 719701 acaaataagc aaaaaagtgc agtgtccgaa ataggcagat gcaaaaaagt gaaattgaag 719761 acagctcaca aagcgcataa aatccaattt aagtaagcgc ttacagataa atgagaagga 719821 gctgtctgat gattagacga aggaaacgca tgtttaccgc tgttacgttg ctggtcttgt 719881 tggtgatggg aacctctgta tgtcctgtga aagctgaagg ggcagcgcgg cagatggaag 719941 cgctgaaccg ggggcttgta gcggtcaaga cggacggggg catttttgtc agctggcggt 720001 ttcttggaac cgaaaacgca tctgttttgt tcaatgtgta cagagacggg caaaaactga 720061 atgctgcgcc tgtcaaaaca acgaactatg tggataaaaa cggttcggcg ggctcaacgt 720121 atacggttcg ggctgttgta aacggtaccg aacagccggc ttctgaaaaa gcctccgtat 720181 gggcgcagcc gtatcattcc gtcccgctgg ataaaccggc tggcggcacg acgccaaagg 720241 gtgaatctta cacgtacagc gctaatgacg caagtgttgg cgatgtggat ggtgacgggc 720301 aatacgagct gatcctgaaa tgggacccgt ccaactcaaa agacaattca caggatggct 720361 atacgggtga cgtgctgatt gacgcgtata aactggacgg cacaaagtta tggcggatca 720421 atctcggcaa aaacatcaga gcgggcgcgc actacaccca gtttatggtg tatgaccttg 720481 atggtgacgg aaaagcagaa gtggcaatga aaacggcaga cgggacaaaa gacggcacgg 720541 gcaaagtaat tggaaatgcc aatgcagatt acagaaatga acaggggcgt gtgctttcag 720601 gccctgaata tctcactgtg tttcaaggtt caaccgggaa agagcttgtc accgcaaatt 720661 ttgaaccggc gcgcggcaat gtgtcggatt ggggagacag ctacggcaac cgtgttgacc 720721 gttttctcgc cggcattgcc taccttgatg gacagcggcc gagcctgatc atgaccagag 720781 ggtattacgc taaaaccatg ctagttgcct ataacttcag ggacggaaag ctgtcaaagc 720841 tttggacgct ggactcctca aagtcaggaa atgaagcgtt tgccggacag gggaatcaca 720901 acctgagcat cgcggacgtt gacggggatg gaaaagatga gattattttc ggctcaatgg 720961 ctgttgatca tgacgggaaa ggcatgtact cgaccggctt aggccatggg gatgccctcc 721021 atacaggaga tcttgatccg ggccggccgg ggcttgaggt gtttcaagtt catgaggaca 721081 aaaatgcaaa atacggctta tctttccggg atgctgcaac tggaaaaatc ctttggggcg 721141 tttatgccgg caaggatgta ggccggggaa tggctgctga tattgacccg cgttatccgg 721201 gacaggaggt gtgggcaaac ggttctctct actcagcgaa aggggtcaaa atcggaagcg 721261 gggttccgtc ctcgaccaac ttcggcatct ggtgggacgg cgatctgctc cgggaacagc 721321 tggacagcaa ccgaattgat aagtgggatt atcaaaacgg cgtatcgaaa aatatgctga 721381 ctgcatcagg cgcagcggct aacaacggca caaaagcaac accaacgctt caggctgatc 721441 tgctcggtga ctggcgcgag gaagtggtgt ggagaacgga ggacagcagt gctctgcgca 721501 tttacacgac gaccattccg actgagcaca ggctgtatac gctgatgcac gatccggtgt 721561 accggcttgg catcgcctgg caaaatatcg cctataacca gccgccgcac acaagcttct 721621 ttttaggaga cggcatggcg gaacagccaa aaccaaatat gtatacgcct taactgaaag 721681 ggggaaggaa cgggctgcgc gcagcccgtt cccatcaaat gaaaccaaaa aagaggcaaa 721741 tggaatacct gaccagaggt ttgattgcgg tacagacaga acagggcgtg tttgtcagct 721801 ggcgttttct cggcacggat catgagacga cggcttttca cctttatcgg gatggaaagc 721861 ggatcacccg cgatccaatc gctgaaagca ctaattttct cgatcaaaac ggaacggctg 721921 actctgttta tcaagtggcg gctgtcaata aaggacggga agaaaagctt tccaagaaag 721981 ctcgtgtttg gcaggaaaat gtcctggagg ttcctcttgc caaaccggaa ggcggtgtga 722041 cgccggacgg aaagccgtac acttacagcg ccaatgatgc cagtgtcggg gatatagacg 722101 gggatggaga atatgaaatg atcctgaagt gggacccgtc caattcaaaa gacaacgctc 722161 atgacggtta taccggggag gtgctcatag atgcctataa actggacggc acctttttgt 722221 ggcgcatcaa cctcggcaga aacatcagag cgggtgctca ttacacgcaa tttatggtgt 722281 atgaccttga cggtgacgga aaagcagaaa tcgccatgaa aacagctgac ggcacaacag 722341 acgggaaagg acatatcatc ggtgatgagc aggccgattt tagaaacgaa cagggcagaa 722401 ttttgtccgg tccggaatat ttgaccgtgt ttaaaggaga aaccggtgag gcgctcacga 722461 ccgtggaata tgaaccgccc cgcggcaagc tggaggattg gggagacggc tatggaaacc 722521 ggatggaccg ttttctcgcc gggaccgctt atttggatgg ggagcggccg agccttgtta 722581 tggcgcgcgg ctactatacg agaaccgtgc tcgtggcata cgatttcaga aacggaaggc 722641 tcaaaaaacg atgggtattt gactccaacc agccgggaca tgaagcatac gcaggacagg 722701 ggaaccacag cttgagcgtg gcggacgtcg acggagacgg aaaggatgaa atcatatacg 722761 gcgcaatggc tgtcgatcat gacggaaccg gcctgtactc aacgggcctc gggcacggag 722821 acgcgatgca tgtaggggat ctggacccgt cacgaaaagg gcttgaagtg ttccaggtgc 722881 atgaggacgc cacgaagccg tacggactgt cgctgcgaga tgccggaacc ggtgagatat 722941 tatggggcgt ccatgctgga actgacgttg gccggggcat ggcggctcat attgatccaa 723001 gctacaaagg atcgctcgtc tggggaattg atccgccggg caatgatggc atgtcgtacg 723061 ggcttttcac gagcaaaggc gaaaaaatca gcgacaaagc gccctcttca gccaatttcg 723121 ccatctggtg ggacggtgat ttggtcagag aactgcttga tcatgactgg gacggaacga 723181 tcggcaggcc aaagattgaa aaatgggatg ctgaaaacgg ctgtctgaag acgatatttc 723241 agccggccgg cgtgttgtcc aacaacggca cgaaaggaaa cccggttctt caggccaacc 723301 tgttcggaga ctggcgggaa gaagtgatat ggagaacgga agacagcagc gcgctccgta 723361 tctatacaac aacacatctc acccgccact gcttttacac gctgatgcat gatccggttt 723421 acaggctcgg catcgcctgg cagaataccg cctacaacca gccgccgcac acgagctttt 723481 acctcggaac gggaatgaaa aaaccgccga agcccgccct gtacatagcg ggaagcaaag 723541 cggaggcgcc gctgtaggag gactaaggga taagacgcaa aggctgaacg ctacgccaag 723601 atgattagag aactggcagg acgaaccaat gctcaagcgc tgtacgcacc ggttttttca 723661 agggaagagc tatccgtgat ggaagctgta taaaaaacga ggaggaatga aaaaatggca 723721 aatcatattt atcttgccgg cgattcgact gttcaaacgt atggagacag cacaaatcaa 723781 gggggctggg ggcagtttct cggctcgcat ctgccggagc atattcaagt gatcaacaga 723841 gcgatcgggg gaagaagctc gaaaacattt gtggaagagg gcaggcttca ggcaatcctc 723901 gatgtgattg agccggatga ttggctgttc gtgcagatgg gccataatga cgcgtcaaaa 723961 aataagccgg agcgctacac cgagccctat actacttata aacaatattt aaagcagtat 724021 atcgcaggcg cgcgggaaaa aggcgcccat ccgcttctca ttacccccgt agcccgcttt 724081 cattacgaaa acggcgtgtt tttgaacgat tttcctgatt actgcattgc catgaagcag 724141 acggccgctg aggagaatgt ccagctcatt gatctgatgg agaaaagtct cgctttcttt 724201 actgagaagg gcgaggaaaa agtgtacacc tattttatga tttcagaagg gattaacgat 724261 tacacgcatt ttacaaaaaa aggcgcaaat gaaatggcga aacttgtggc aaaaggcata 724321 aaggagctcg gcctgccatt gacagaatcg atcatcaaag aaaggtgaaa atgtgatgag 724381 aaaactgtat catggcgctt gctattatcc ggaattatgg gatgaagaga cgattcagca 724441 ggacattgac atcatgcgtg aagttggcgt aaatgttgtg cggatcggcg aatttgcctg 724501 gtcagtcatg gaacctgaag aaggaaaaat tgacgtcggt tttttcaaag aaatcatcgc 724561 ccggctgtat gatagcggga tcgaaacgat tatgtgcacg ccgacgccta ccccgccgat 724621 ttggttctca catggccggc ccgaacgcat gcatgccaat gaaaaaagag agatcatggg 724681 gcatggctcc cgtcagcatg cctgtacgaa caacccgtat ttccgaaaaa aagccgccat 724741 catcaccaca gccatcgcca aggagcttgg ccggctcccg gggctgatcg gatggcagct 724801 agacaatgag tttaaatgcc atgttgcaga atgcatgtgt gagacatgct tgcgcctatg 724861 gcatgactgg ctcaaaaatc gctacggggt aattgagcgc ttgaatgaag cttggggaac 724921 cgatgtgtgg agcgagacct atcagacgtt tgagcaagtc ccgcagccgg gaccggcccc 724981 gtttctgcat catgcctctc tacgcactat gtatcagctg ttttcgatgg agatgatcgc 725041 ttcgtttgcg gatgaacagg ccaaaatcat ccgctgctat tcagatgcgc cgatcacgca 725101 taacggatca gtcatgttca gcgtggacaa tgagcgaatg tttcagaatc tcgattttgc 725161 ctcctatgac acgtacgctt cgcaggaaaa cgcctctgcc tttttattga actgtgattt 725221 atggagaaat ctgaaacaag ggcgcccgtt ttggattttg gaaacgagtc cgtcgtatgc 725281 cgcctcgctt gaaagctccg cttacccgca cgcagacggg tatttgcagg ccgaagccgt 725341 atcgtcctac gccttaggga gccaggggtt ttgctactgg ctatggcgac agcagcgttc 725401 aggcagcgag atttcccacg gttcggttct cagtgcctgg ggcgaaccca ccatcggcta 725461 tcaaaatgtg ctggcggttg agcgggcaag aaaggaaatc gagcctatta ttctatcgac 725521 tgaacccgtt caagccgagg cggcgatgac ttactctgac agagcaaaag catttattaa 725581 aactgagcct caccggggac tccggcatcg ttcgcttgtg acgcattttt atgaacgtat 725641 tctcaacacg gggattcacc gtgaccttat tccggaaggc gctccactgg acggctatcg 725701 cttgctgttt acgccatttg tgccgtattt gtcttctgaa tttatcaaaa aagcttcggc 725761 attcgctgaa gcgggcggca tctggatcac cgggccgctg acaggaggac gcacatgcga 725821 gcataccatt cataccgatt gcggacttgg cgaacttgag aaaacgtcag ggatcaaaac 725881 actttttacc tttccgatga atgagaacgt gaatacagga aaagcgtttg gcatcacggc 725941 gccgctcgga ctgtggagcg cggtgtttga cacagagagc ggaaacaccc ttggcacggt 726001 tgaagcagga ccgggggcgg gccatgcttt tctgacggaa cggaattacg gcgaggggaa 726061 aattgtcatg ctgggctcgc ttccatccgg gaaagaaggg gatgcgatgc tggaagcgct 726121 cgtcaggcat tatgcggagg aagctgttat ttccagccgg tcggatgtga cacccggcac 726181 gatcgttgcc ccgcgtatag gcgaaaacgg ccttgtgtgg atcgttgtga atatggatgg 726241 aaaaggcggg agcgtgacat tgccggaatc gggaacggat ttgttgacgc accgcttgga 726301 aaaggcgggg agactggcgg tcggaccgca tgaataccgt gtgattcaat ttgacaatca 726361 cagctgattc tttgtatcga atcagctttt ttctatggag ggagagacag atgaaaaaga 726421 tcaaatggtt atcaggacag ccaaaggtga caagcggcgt gacgtggggc atgccatgga 726481 aaaaaggaga attaaaaaaa ggagaccgtc tggcgcttat gaatgaaaac gcggaaacgc 726541 gatatgtgca aagcgaaccg tcggcctatt ggccggacgg gagcatcaag tggacgaagc 726601 acgcggcggt gtttggcggt caggaaaacc aaagctttac agtgcacaaa agagaagtgc 726661 cgcagccaac tgaatcgctc agcattcttg agacagagca tgatatccaa gtggatacag 726721 gagcactcgt ttgtaccatt cataaaacag gatctgattt cattcaatca ttgcagatca 726781 atggaaagcc gatcgccgca ggcgggaggc tcgttgcgat aagagaaacg agaaaagagt 726841 cagcggcgaa aatggttctt ttgcatgaaa ggtctgtcag ctttatcaaa cgggcggcga 726901 ttgagcagag tggtcctgtc aaagcagtag tcaaaatcga gggagtgcat gtgcttcata 726961 aaacgtatga ggaatggctg ccgtttgtca tccgattaac gttttatgcc gggctgtctg 727021 agatcggcct tgtgcacacg cagctgattg acaggagcgg taaactagaa ttcgttaagg 727081 ggctcggcat cgaattcgac ctttttttgg agggagagcc gtacaaccgc catttccgct 727141 ttgcgggaga gaaagggatg tataaagaac ccgcccagct gtttggcaca cgtaaattca 727201 atgaacgata tccgctttat gaaaaacaaa tcaatggcga aatgctgtct ccagatgaag 727261 agcataagga atggtttgca catggcacac agaatgcggt ttgggacgat gtcaagatcg 727321 tgcaagattc cagcgatcat tacagcctgt caaaacggac cggaaaagat tatgcgtggg 727381 ttggaatgct gcatggcagc cgggcgaagg ggctctgcta tgcgggcgga aaaaatggcg 727441 gtgtggctct cggcctgcgg tatttctttg agaaatatcc ttcagcactg gaaatcacag 727501 gtcttgccgg cagccgcccc aaaatgacta tctggctttg gcctccggac ggcgaagcga 727561 tggatttgcg gcattataca ggaaacactc acgtggccag cgcgtatgaa ggctttgatg 727621 aaatgcgctc tgatccgaca ggcattgcga acacaaatga aataagcctg gcgtgctttt 727681 cgcacatgcc gtctgacgaa gtcctcaatg cgctggctga caaatggcag gcgcccccgc 727741 tcattgtatg cgagccggac gtctattacg aatcaaaagc actcggggta tggagcatca 727801 ttgacacatc ccatccgctc aaaaaagagc tggaagaaca gcttgatgcg gcctttctgt 727861 tttataaaaa ggaagtagag caacgcagat ggtacggttt ttggcattat ggcgatgtca 727921 tgcatacgta tgacccgatc cggcatatgt ggcggtacga tctcggcgga tacgcatggc 727981 aaaacaatga gctcgttccg accctatggc tgtggcaggc gtttttccgc tcaggcagag 728041 aggatatctt ccgaatggca gaagccatga cccgccatac gagtgaaacg gacagctttc 728101 acctcggtga atatgccggg cttggctcac ggcataatgt tgtgcactgg ggatgcggct 728161 gcaaggaagc gagaatcagc atggccgggc ttcataaatt ctattattat ctgacgggtg 728221 atgaccggac gggagatctt ttgacagaag tgaaggatgc cgattatgcc cttgtcaaaa 728281 ccgatccgat gcgcgctttt tacgagaaag gcaagcaccc gactcacgcc agaacgggac 728341 cggactgggc ggcgttttgc tcgaactggc tggcggaatg ggagcggacc gaaaattcgg 728401 aatatctcaa aaaaatcgaa acgggaatca actgtctgaa gcggctgccg ctccgcttat 728461 tatctggccc gacatttgaa tatgatccgg cgacctcgat gcttcatcat atgggagacg 728521 gcattgcggg cggatatcat atgatcattg ccttcggcgc gccgcaagtg tggatggagc 728581 tggctgagct tcttgatgac tgggaatggg aggatatgct gagtgaattc ggcgaatttt 728641 acacactcag tgatgaggaa aaacgaaaaa aaagcggagg cgctcttcat gacgggcatt 728701 ttcactggcc gatgttcgcc gccggtatga cagcctacgc cgcaagaaaa aagcaagatc 728761 ctcatctcgc cgccaaagcg tggaatcttt tgctagaaga taagctcagc catacgccgc 728821 ttccgatcaa accggagcgc atcgagacat ggacgcagct agaggagctt ccatgggtga 728881 caacgaacac tgtctctcaa tggtgtttaa atgtcatagc ggcgctggaa ctgatcggag 728941 attcccttcc ggcaaaaaaa gaaacatcgg gcaaaaaagg ataacagccg gaatttcata 729001 ggagaaatgg tgcaaaaaat gaagattgca agaatttatg taagcgcttt atattgagag 729061 gggcaaaggg gaaatgcaaa ttgaaaaaag ggggacttac gcaacatgaa aataagaatg 729121 cgaaaaaaat ggatggcctt gccgcttgct gccatgatga tcgccggatg cagccattcg 729181 gaaacatcca attcagcaag cggttcgaaa gatacgatca aaattatggc gccgctctta 729241 tcgccggaaa gcccaagtga taagagccct tcattaaaag cgctcgaaaa atacacaggc 729301 aaagagatta aggtcacatg ggtgcctgat tcatcctaca acgacaaatt caacatcgtc 729361 atggcttcag gagagatgcc tcacgcgatt gtcattaaag ataagtcagc cggctttatc 729421 aaatctgtca aagcaggggc gttttgggag ctgtctcctt atttaaaaga ctacaagaat 729481 ttaagccagg cagatgaaaa gattttgaag aacagctcgg tgaacggcga ggtgtacgga 729541 atctacagaa cgagggatct gatcagggcg tgtatgatca tcagaaccga ctggctgaaa 729601 aatgtcggtc tggatatgcc ggaaacgctt gatgatttct atgaagtgct gaaagccttt 729661 aaggaaaaag atcctgacgg aaacggcaag gatgatacgt acggcatggt cgtgccgaaa 729721 tggatgggac tcggcaacgg aagcccatgg gatgttctgc aaatctggtt cggcgctccg 729781 aaccgctacg gtgttgaaaa cggaaagctg attccagatt ttacaacgaa ggaatacatg 729841 gatgcgctca cgttttttaa aaagctctat gatgagggct tgatcaataa ggactttgct 729901 gtcatggatt ctgcgaagtg gaatgatccg gttgtaaaag gaaaagcggg tgtcatcgtt 729961 gatacaggct caagagcgtc tcaaatccaa agcgcgatgg aggaggcgga tgagtcgaac 730021 aaggatatca ttgatatcgt cggctcgctt gagggaccga atggcaagcg caccttcccg 730081 acatctggtt attcaggcat gatcacgata ccaaaatcaa gcgtcaaaac cgaaaaagag 730141 ctgaaagagg tgctgtcctt cctcgataag atgaatgata aggaagcgca gattctcacg 730201 aacaacggag tgaagggccg caattacgag ctcaaggacg gcgtattcac ctcacttgaa 730261 aaaaacaata aatctctcct gtatgagcat gaaggcttgg cacagttcag catgtcgatt 730321 ccgaaaagcg agtattacat cgaagaccag aaaaccaagc tcttccagca tcgcaaggac 730381 atcataaccg aaggagaaaa aatagccgtc tttaaccctg ctgagtcgct tgtatctgat 730441 gtctataccc aaaaaggagc ccagcttgac aacatcatcc tcgacgcgag aacacaattt 730501 atcattggag aaattgatga aaaagggttc gatgatgcgg tggagctttg gaaaaaaagc 730561 ggcggcaatg aactgatgaa ggacttgaac aaattgtacc aatcgtcaaa ataaaccgat 730621 gcgcctgcct ttcggcgggc gccccggtat cacgaaagga gaacagatat ggaaacagtg 730681 ccgaagaaga gagatgcacc tgttctcacc gctggaaaag gcatcagctg gatggctgcg 730741 ctcaaacggg acaaatggct ttatcttctt cttattcccg gtctgcttta tttcttgatt 730801 ttcaaatact tgccgatgtg gggtgtgctg atcgctttta aagactattc gccatatctc 730861 ggcttctgga aaagcgaatg ggtcggcttt gattatttca aagacttttt tatgaatccg 730921 gattttttcc ggctgctgcg caacaccctc atgctggcga gtctggatct tttgtttgcc 730981 tttcccgcgc ctctcatttt ggctctgctt ttgaatgagg taagaaaggc cgtgtataaa 731041 agatgtatcc aaacctttat ttacgtaccc cattttgtat catggacaat tgtggtcagc 731101 atcaccttcg ttttctttac tgtcgataca ggtgtgatca acaaattgat tatgagcctg 731161 acaggtgagc agatttcttt cttgtcggat gcagactggt tccggccaat gattgtgatg 731221 caaagcattt ggaaggagac aggctgggga acgattctat ttttggcagc gcttgctacg 731281 gttgatcaag agcagtatga agcggccatc atggacggag cggggcggtt caggagaatg 731341 tggcatatta cgctgccggc gattagaagc accattatcg ttttgttgat tttaagaatc 731401 ggcagctttt tgaatcttgg ctttgaacag gtgtatttga tgacgaactc actcaaccgc 731461 agtgtggctg acatcttcga cacgtatgtg tacatgatgg ggattaccca aggggcgtat 731521 agctacagca cggcggtcgg tttgtttaaa tcagttgtcg ggattatctt gatttttggc 731581 gccaattaca ttgcgaaaaa gtttgatcag gaaggattgt tttagaggag ggagaggtat 731641 ggctgaaatt cacacgatgc acaacaccaa agccggacgg gtgtttgacg tctgcaacat 731701 tctgtttctc ggcggtgtcg gcgcgattac cattttgccg tttttatata ttatcgccgg 731761 ttcctttgcg acagaagcgg aactcgccca gcggagcttc tttattttcc cgaaaacctt 731821 tacacttgat gcttacaagt atgtgttttc gacaccgacg ttccttcgaa gcatgggcgt 731881 gtccatcttc atcacggtgg ttgggacggc tgtacagctg ttttttacct tcacgatggc 731941 gtatccgctg gcgaaacggc atgtgaaggg acggaatctg ctgttgaatc tggtgatttt 732001 ctccatgctg ttttcaggcg gcatgattcc gacgtacctt gtcgtaaaat cacttggcct 732061 tttggatacg tattgggcat tgattctgcc gatggcgatt aatccgttca accttattat 732121 tatcaaaaac ttctttcagc agctgccgcg cgagctggag gaatcagcaa aaattgacgg 732181 ctgttccgaa atcggcgtct tctggcggat cgccctgcct ctgtcaaagc cagttattgc 732241 gacctttgcg ctgttttatg cggtcgggat ttggaatgat ttcttccacg ctctcttata 732301 tatcaatgac agtgcaaaat ggccgctgca aatggtgctt cgccaagtca caattttatc 732361 ggatttaacg gcgaccaatg gtgatacgat gcaaaatgca gttccgccgg agcagggaat 732421 taaactcgct gtcattgtca ttgcgacgct gccgattttg gcggtctatc catttttaca 732481 aaaacacttt gcaaaaggaa tgctgatcgg ttcggtgaaa ggctgagaaa gggagtgttt 732541 catatcagta cattagatca gattaagatt gcctatatcg gcggggggtc ccaaggctgg 732601 gccagaagcc tgatgagtga tttgtcgatt gatgaacgga tgtcaggcac ggtggcgctc 732661 tatgatcttg attttgaagc cgctcagaaa aatgaagtga tcggcaatca cagcgggaac 732721 ggcagatgga gatatgaggc tgtttctact ttgaaaaagg cgttatcagc cgcggatatc 732781 gtcattattt ccattttgcc gggatcactg gatgatatgg aagtcgatgt gcacttgcct 732841 gagcgctgcg gtatttatca gtctgtaggt gatactgtcg ggcctggagg gatcatcagg 732901 ggcttgcgtg ctgtgccgat atttgcggaa attgcccggg caataagaga ctacgcacct 732961 gaatcatggg tcattaatta tacaaacccg atgtctgtct gtacaagagt gctgtataaa 733021 gtgtttcccg gcatcaaagc gattggctgc tgccacgagg tattcgggac gcaaaagcta 733081 ttggcggaaa tggtcacgga aaggctgggg attgaggtgc cgcggcgtga ggatatccgc 733141 gttaatgtgc tcggcattaa ccattttaca tggatcacaa aagcctctta ccgccatatt 733201 gacctgttgc ctatattccg tgaattcagc gcgcactatg gggaatcagg atatgagctg 733261 gagggggaat gctggaggga cagcgtcttt tgttcggcac accgtgttgc gtttgattta 733321 tttgaaacgt atggcgccat ccctgctgcg ggtgacaggc atctggcaga gtttcttccc 733381 ggcccatacc tcaaacagcc tgaagtatgg aaatttcatc tcacacctat atcattcaga 733441 aaacaagaca gagctgagaa acgacaagaa acagaacggt tgatcgtgca acaacggggc 733501 gttgctgaga aagcttcggg agaagaaggc gtgaacatca tagcggctct tctcggattg 733561 ggtgaactcg tcacaaatgt aaatatgccg aatcaaggcc aggtcttaaa ccttcctata 733621 caagccattg tcgaaacaaa cgcattcatc acaaggaacc gtgtccagcc gattttgtcc 733681 ggagcgcttc cgaaaggtgt ggaaatgctg gcggctaggc atatatccaa tcaggaggca 733741 gtggcggacg caggtttaac aaaggatact ggcctcgcgt ttcaagcctt cctcaatgac 733801 ccgcttgtcc agattgaccg cagtgatgca gagcagcttt tcaatgacat gctccaatgc 733861 atcatgcaaa gctgagcttg ccgattagct ctttccggtt tagaaaggaa agcattgacc 733921 atactgatag tataatcaag aagtaggtgc tatcaatatg ggaaattatt taagtgttgc 733981 ggtagaactg gtctgcggtt taggcatttt atttatcatc ttaaagcttc tcgggaaaac 734041 ccaattttct caaattacgc cgtttgactt tatttctgct ttaattttag gtgaattggt 734101 cggaaatgcc gtctacgatc atgaaatcaa aatcaaagaa attatttttg cttcgctatt 734161 gtggggcgtg ctgatttata ttattgaatt tatcacgcaa aaaatgaaat catcgcgaaa 734221 gttcttggag ggcgagccga atatcgtcat ccgcaaaggg gagcttcaat ataaagtaat 734281 gaagaaaaat aagatagaca ttaaccagct gcaaagccta ttgaggcaag ctgggagctt 734341 ttcgatccaa gaagtagaat atgcgattct tgaaacaaac gggatggtca gcgtgcttcc 734401 aaaatcagac tttgacaaac cgacaaataa ggatttgcag attccttcga agtccgtttc 734461 tctgccgatc acgttaatca tagatggaga gattgtgcgg gataatttga aggaagcagg 734521 tgtggatgaa cagtggctga aacaagaatt gaaaaagaag aacattgata agacagagga 734581 cgtgttattt gcagaatggc ataaaaataa gccgctgtat actgtaacgt acgaacaaag 734641 cagatcaaca tgactcttag aaaaaagctt gcagcaaggc gcaagctttt tattgattgt 734701 atgtcccttg tttgacagca cgtacatggt acatgctcac ttcagtgctg atcagatagt 734761 caggctttgg tttgcctttg tttgctttat ggccggcgat atgcgcatcg cttttttccc 734821 attgcttcca gtgatcctct gattcccagc gaatcatgac aacaacttct tcatcaccgc 734881 ggcgcacatt tttctcaagc actgtcacat caattaaacc ttcttgtttt tcaatgattc 734941 cttcagcgct gaaacgttct atgactttat ctgcaaagcc ttctttaacc gtcatttttc 735001 tcaactgtac aaacatttgt ctcactccaa tcattctcac atatgaataa ttgtaaatga 735061 aattcattct caatgtcaaa gaaagcgcag ggcggaatcg aaccgccgtg cgcaacagtt 735121 tattctttta ataaaaacac atttccgtct tcgtccttaa attgaacgaa ggtgccccac 735181 tccatttgat tgggctcacc gagaaattct acaccgtttg tcttcatttt ctcgtatgta 735241 ccaaagatgt cttcgcattc aaacacaata gaagccttca tttgctctga gcctttcatc 735301 atggctttcg ggtaaatgac taaacgagtc tcggctcctt ttggcgcaac ctccagccag 735361 cttgcttcag gtcccattgg gtgatccgct gcaatatcaa agcctacctt ctctgtccaa 735421 aattgcttcg ctttctgctg gtcctcgaca tatacagcaa cagtgccaat ttgtttgatc 735481 atagggaaac ctccaagttg aaaagataat aatactataa cctgtttacg gccgaagtaa 735541 cataaaaaaa tcagccggga aaccggctga ttattaaaat gagcagctta caacatcgat 735601 gtgatttgtg tctaaggcga aataaaccca gcggcgccgt gaggaatccc aataaaagcc 735661 gccgacggat cttctgccaa ggatgatcgg gtaaaaccaa aatgagcggc cattggttaa 735721 ccagacatag gtaaatcgga aaaggcaagg acgaatggtg attggttcaa ctaacaaaac 735781 ggctccttga gaaccctgcg gttttggggg tttcgctggt atttgggaag gaggaggtcc 735841 ctgcggcgca ccgccgaagc ctgggctggc accgctgcca ataccagggc cggagccgcc 735901 gccaaagcct ggaacagcac caccgccaat gccaggaccg gagccgccgc cagagcccgg 735961 aacagcgccg ctgccaatgc caggccatgg atatcggtat tcatattcaa aagcaggcca 736021 aggctcataa aaatgccccg caaacatata aggatcaaca taatacatgt gataacgtcc 736081 tttctcattg taaactgtac attgcagttt atgcgggcgg actcttattg gtgcattcgc 736141 ctaaggatat gaagctggaa tgctctcaga gagcagaatc atttgatttt tctctagtct 736201 tattcacaat tccgatttat cattttataa tgaaagtgct tctattacga aaaaggagac 736261 agaccgtgaa tatcgatcaa ttattatatc aatatatcat agacaacact gcggatatta 736321 ctgagaaatg gttcagtttg cgttgccagc taaaaggcga gctatattcc gccagccatt 736381 taagtgaaga aacgaaaaca cttttaaccg agcagcatac atttaccaat ataacaatcg 736441 caagcgcatt tctggaggat caaaccgatt ttcaagaaaa catgacaaaa tgggcgcaaa 736501 acgttgcgaa aaacagggta gagcaggatg ttcaagtgca tgaggtcgta gaagccatat 736561 ccaattcaag aatctcattc tgggacgcag tcgccacatt tataaaagag aatcaggaga 736621 ttgtgacaaa tgaggatgca gaccgatgga accgcattgt gaatcagtcg ttcgataagc 736681 tgattattga attctccgag cagtaccaaa aattcatgct gatgaggctt acatctcagc 736741 aggaactgat ctcagagctt ggctgcccgg tcatttccat tgccgatgga atcgggatat 736801 tgccgcttat cggctccatt gatacaaaac ggcacaggtc attttagaaa cagtgccggt 736861 ccgctgtgtc gagagaaaaa tcacaagcct cgtcgttgat ctttcgggtg ttccgattgt 736921 ggataccatg gtggctcagc aattgtacaa cctgtctaaa acacttttct tattaggcgt 736981 caaagccgta ttttcaggaa ttcgcccgga tgtggcccaa acatcgattc aattggggct 737041 tgattttagt gaatatgaaa cgtacggcac gctgaagcag gcattagaaa acatgggtgt 737101 ccgctgtatt gttgaggaat tggaagaaaa caaataggaa gtttccaggc atatgattgt 737161 ccgtcaccgg gtgatcatat gcctttttga tttgaacaga aatcaccatt gatttatcga 737221 aaaaaacata atattataat tcttataaga atactgtgaa ttaaaaccta ttcaacaggg 737281 gggaaggtct tttggtttct aaatcaacga ttgatccgga agtgattgaa aaaatcatca 737341 gctcgctgga aacactcgat ttcggcacgg ttcagattac ggttcatgat tctcagatta 737401 cccaaattga gaaaatagaa aagcaccgtt tttcgctgaa aaggaaagaa tcaaaatgat 737461 aatgtaaagg gcgtttgttt tcattaaatt ctccttaaaa catatacata tttcatccaa 737521 tttttatata atagaccttt aagatcattt tttaggagga tttttgacat gcaagctacg 737581 gttcacgaga gtaagcaatc gatcatgcaa cgcattttga cagtctttgt cttcacattg 737641 ctgatcgcga ctgtcggcct ttttatcggc caatttgttc ctgtcgcttt gatgctgccg 737701 ctttctattc ttgaagtggc gatgattatt ctggccttct ggatgcgcag aagaaaagcg 737761 gtcgggtatg cgtttgtata tacattcgcg ttcgtttccg gcattacctt atttccgatc 737821 gtcagccatt acgcttccat cgccggcgcc tatgtcgtgc tcgaagcctt tggctctaca 737881 tttgtcattt ttgccgtctt gggcacaatc ggcgcaaaaa tgaagaagga tttatccttc 737941 ctgtggtcgt ttctgctggt tgcggtgctc gcactcgcag tggtagggat tttcaacatt 738001 ttcagcccgt taaactcagc ggcgatgatg gcgtattccg tgatcggaac catcgtcttt 738061 tccctttaca ttttgtatga tttgaaccaa atcaagcacc gccacattac ggaagacttg 738121 attccggtta tggcgttatc gctgtaccta gactttatca acttgttcat caacctgctc 738181 cgcttcttcg gcattttgag cagtgatgat taatgaaaaa gcgtctgtca ttggataggc 738241 gctttttgcc atacatcaaa aaggcaggtg gagtattggt gaaaaaacaa atgggcgcat 738301 atgtatctct ggcagcagct atggcgatcg tcggcagttc tgtcgttgtc ggcaagctga 738361 tggtcgaacg gattccggtc tttctttcct caggattgcg ttttttgatc gcttctgtcg 738421 tattgctcat gctgctgttt tgcattgaaa aagggtttcc ggctttgacg aaaaaagatg 738481 tgttcgtatt actggtgcaa tcattcacag gcgtgttttt gttcagtatt tgcctgctgt 738541 atggggttca atatacgacg ggaacggaaa gcggcatttt gacaagcaca acccccatgt 738601 tgatcggtat tttatccttt ttcctgctga gagaaaaaat tgagaaaaag acgctgatcg 738661 gcattttgct ggcggtttgc ggcgtaatgg cgattaattt gtttggagcc gggagccaag 738721 acgggacgcc gcacgcctta ttcgggaaca tgctgatcat tgctgcagtc attggcgaag 738781 cgttgtttac attgatggcc aagctgctat ccccgcatat ttcggcactg gcgatttcga 738841 ccttcgtatc gctcttcggc ttcctgtttt ttctcccgtt tgctttgttt gaggcctctt 738901 catttgatta cagcgtgccg actgttttgg attggtcgta tgtgctgtat tacgcgcttt 738961 ttgtcactgt tttggcgttt tacttatggt atagcggggt gacgaaggtg ccggcgggtg 739021 tatcgggcat tttcacatcc gttcttccgg tctcagctgt cattttgtca ggcgtgatat 739081 tgaaggagcc atttgagttt gtgcatttca tcggcattgc atgtgtcatc ggcggcatat 739141 ttgttacggt cataaagaaa aaacagccgg atgcgtatcc ggctgcagaa gaaaagacgc 739201 tatagcctgt ccggatcgga cgggtttttt agtctttaaa cacgctcagc ctttcaaaaa 739261 gatcaccaag catcttcacg aacatgtctt tttcctcgtc gctgtagttt tccatgacag 739321 cggatatttt gctgaaatgg ccgggcagaa attgctccag gcgtgctttg ccttctgttg 739381 tcagttcaat gctgattttt cgtttatcct ctgtgtgatg cctgcggctg acaaaaccgt 739441 ctctcgccag cccgtctagc aggcctgtaa ttgttgcttt cgtgacattt gaccgcttgg 739501 caagctctgt cggacttaac ctatgatcct tggcatcaaa gagcagcatc aggattttga 739561 attttccttc tgaaagccct cggccagcaa agtaatgctc catcacatga ttcatttttt 739621 ttgaaatatc aaaaagagat aaaaacaatt caagagagcc ggcgtcaata ttggcatacg 739681 tttcggcgtg ctctgttata tgcttatatt tcggtaaatg ttttaattcc atcgcaatta 739741 gctcccgtac attcgttgtg acacgattat aaaggaggga aaaccataac gcaacttggc 739801 ttggagatga ttgacagctt ttcttgggac atagtaaggt aatatagtta ggcgcctaac 739861 taatacatat agagctgaaa aggtggttat tgatatgaaa catatgttaa tagcaggagg 739921 cggaatcggc ggcttgtcag cggccatttc tctccgtaag gcagggtttt ccgtcacctt 739981 atgtgaagcg gcttcagaaa atcgaaaaac aggtgcgggg attcttcagc cgcaaaacgc 740041 actggcggtg ttgaaagaac tgggcgtatt cgaagattgc tgtaagcacg gctttcaaac 740101 agaatggttt aaaacgtttg atgaacaggg gaatttgctg tttcaagtca gtgaatcctt 740161 tttagacgat tcacttccgg gacgcaataa tatcctgcgc aaaacgttaa atgacattct 740221 catgaagcat gccgaggcag tgggtgtaga catcaagtgg gggaaaaagg ttgtcgccta 740281 tgaagaaact gctgaatcgg tcactgcctt atgtgaagat ggagaaaaga tgcaggctga 740341 cattctggcg ggctttgacg gcattcactc cgttgttcgt gataagatgc tgcaaaagga 740401 aacggaaaaa gagcatctcg gcatgggagc gtggcgcttt tatatcgaac ttcctgatta 740461 cacattcgag gacgcaacat tcatgtatag aagcggagac acacaaatcg gggtggtgcc 740521 attggcacaa cacgctggct atgtcttcgt cctccagcct tgcacgagcg attactggga 740581 tgaggaagat acccggtttg atagagtaaa agagattctt tctggttttc gggggctgga 740641 ttttgtcaca aagcacatgt caaaacagca tcctgtcatc tttaacaaac tggagcaggt 740701 cgccgtgcag gagccatggc ataaaggccg cgtcatcatc ggaggagacg ccgcccacgc 740761 cggtgcgcca accctggcac aaggagcggc aatggcgatc gaggatgcca tcgtcctcgc 740821 cgaagaactc caaaaccacg ccgaccacga aacagcatta caggcgtact ataaaagaag 740881 agccccacga gcgctcaaag tccagaacct atcatctgaa atcgtccgcc gcaggctgaa 740941 aggagagccg ggagcggaag aactgattgg ggagtgctat gcggtgttga gggaagggta 741001 ttaaatagga aaagtccaga aagtgatttc tggacttttt agtcttgctc tgttttattc 741061 cttatccgct caatcacctc atgcagcccc tcaggcttat aaaactccac cggtgaactg 741121 cctttctcaa acgaaatcgt ctcggcttca atcagcgcga catagcgccc gtttactttt 741181 gcgagatgaa tagaatcgcc aaaatccgct agcaatccct taatctctgt ttctccgact 741241 ttcattttca gctgggcctc tggcgtgtgc tcgatgattt gggcggaggc ttcgatgact 741301 tgatgggtgt cgaggcgctc ttggatttcc cgtttttcgc ttgcttccca aatctcaatg 741361 tcgtgctcga actgcttgag ttcttcgctg ttgtcttcaa atgtctcgta gacgtgctct 741421 tgtaccatgt tcatgacctg atttttcatg atttctggca tcgattctcc gtactcgacg 741481 aatttcagaa agtcctcaaa atagcgggcg tgcgaggcct ggtggatttt cagttcacct 741541 tcctcgacca ttccttcctc tggcatgtac gggtattgga tgcttttcat gttttttgtc 741601 gtgatcgcca tttcgacttt tttaatgaga gaagacgcgt cagagatgcg ggcgaccttc 741661 ggctcaaaat cacatttcat aatgaagaca aatgactcat caaagtattt tctcggcacg 741721 gccgaagcga cgagaaacac gccgccgcga accgcgcttg tgtcaaggta cgtgcggacg 741781 aactgctcgc tcagctcatt gaagtcttct tttgtttccg ccagacgcgc gcggttgaac 741841 atgttgtagt ttgggttgga atcgagctcg tggccgggct cgacgataaa atggccgatt 741901 ttcgtcggca cctgctcgga ctgcggatgg cggtcggctt tccgtttaac gatttttttc 741961 agttccccgt cgagaaagtc cttcagctcg ctttcttcaa attctcccgt atcaagggtc 742021 tggaagtgct tgaactgctt gttcgcctgc tcatctttgc cttccacctg tatgacataa 742081 aaggataaaa accgaatttc aaaatccata tataaactca ccttattcgc gtattgtaca 742141 gcttctcaag tatagaaaaa acagcgatca tgcgtcaatt gggagaacgg aataatcatg 742201 accatgaaag ggaaatgtag tcaaatagaa ggcatttcat acggaaagga atggttcgat 742261 gaaggaaaca agcccgattc ctcagccgaa gacgtttggg ccgctcggca atttgccttt 742321 aattgataaa gacaaaccga cgctttcgct gatcaaactg gcggaagaac agggcccgat 742381 ttttcaaatc catacacccg cgggcacgac cattgtagtg tccggccatg aattggtgaa 742441 agaggtttgt gatgaagaac ggtttgataa aagcattgaa ggcgccttgg aaaaggttcg 742501 cgcattttcc ggtgacggat tgtttacgag ctggacgcat gagcctaact ggagaaaagc 742561 gcacaacatt ctgatgccga cgttcagcca gcgggccatg aaggactatc atgagaaaat 742621 ggtcgatatc gctgttcagc tcattcaaaa atgggcaagg ctcaacccga atgaagcagt 742681 cgatgtcccg ggagatatga cccggctgac gctcgacacc attgggctat gcgggtttaa 742741 ctaccgcttt aacagttact acagagaaac gccccacccg tttatcaaca gcatggtgcg 742801 ggcgcttgat gaagcgatgc atcaaatgca gcggcttgat gttcaagata agcttatggt 742861 cagaacaaag cggcaattcc gctatgatat tcaaacgatg ttttcgttag tcgacagcat 742921 tattgcagag cgcagggcga atggagacca ggatgaaaaa gatttgctcg cccgcatgct 742981 gaatgtggaa gatccggaaa ctggtgaaaa gctcgacgac gaaaatatcc gctttcagat 743041 catcacgttt ttgattgccg gccatgaaac aacgagcggc ctgctttcct ttgcgactta 743101 ctttttattg aagcatcctg acaaactgaa aaaggcgtat gaagaggtcg atcgggtgct 743161 gacggatgca gcgccgacct ataaacaagt gctggagctt acatacatac ggatgatttt 743221 aaatgaatca ctgcgcttat ggccgacagc tccggctttc agcctttatc caaaagaaga 743281 cacagtcatt ggcggaaaat ttccgatcac gacgaatgac agaatttctg tgctgattcc 743341 gcagcttcat cgtgatcgag acgcttgggg aaaggacgca gaagaattcc ggccggaacg 743401 gtttgagcat caggaccaag tgcctcatca tgcgtacaaa ccattcggaa atggacaacg 743461 ggcctgtatc ggcatgcagt ttgcccttca tgaagccaca cttgtgttag gcatgattct 743521 aaaatatttc acattgattg atcatgagaa ttatgagctt gatatcaaac aaaccttaac 743581 acttaagccg ggcgattttc acatcagtgt tcaaagccgt catcaggaag ccattcatgc 743641 agacgtccag gcagctgaaa aagccgcgcc tgatgagcaa aaggagaaaa cggaagcaaa 743701 gggtgcatcg gtcatcggtc ttaacaaccg cccgcttctc gtgctgtacg gctcagatac 743761 cggcaccgca gaaggcgtcg cccgggagct tgctgatact gccagtcttc acggcgtaag 743821 gacaaagaca gcacctctga acgaccggat tggaaagctg ccgaaagagg gagcggttgt 743881 cattgtgacc tcgtcttata atggaaagcc gccaagcaat gccggacaat tcgtgcagtg 743941 gcttcaagaa atcaaaccgg gtgagcttga gggcgtccat tacgcggtat ttggctgcgg 744001 cgaccacaac tgggcgagca cgtatcaata cgtgccgaga ttcattgatg agcagcttgc 744061 ggagaaaggc gcgactcggt tttctgcgcg cggggaaggg gatgtgagcg gtgattttga 744121 agggcagctt gacgagtgga aaaaaagcat gtgggcggat gccatcaaag cattcggact 744181 tgagcttaat gaaaacgctg ataaggaacg aagcacgctg agccttcagt ttgtcagagg 744241 gctgggcgag tctccgctcg ctagatcgta cgaagcctct cacgcatcca ttgccgaaaa 744301 tcgtgaactc cagtccgcag acagcgatcg aagcactcgc catatcgaaa ttgcattgcc 744361 gccggatgtt gaatatcaag agggcgacca tcttggcgta ttgccaaaaa acagccaaac 744421 caatgtcagc cggattcttc acagattcgg tctgaaggga accgaccaag tgacattgtc 744481 ggcaagcggc cgcagtgcgg ggcatctgcc attgggccgt cctgtcagcc tgcatgatct 744541 tctcagctac agcgtcgagg tgcaggaagc agccacaaga gcgcaaatac gtgaactggc 744601 gtcatttaca gtgtgtccgc cgcataggcg cgaattagaa gaactgtcag cagagggtgt 744661 ttatcaggag caaatattga aaaaacgaat ttccatgctg gatctgcttg aaaagtatga 744721 agcgtgtgac atgccgtttg aacgattttt agagctttta cggccgttaa aaccgagata 744781 ctattcgatt tcaagctctc caagagtgaa tccgcggcaa gcatcgatca cagtcggtgt 744841 cgtgcgcggc ccggcgtgga gcggccgtgg cgaatacagg ggtgtggcat caaatgattt 744901 agctgagcgt caagccggtg atgatgtcgt gatgtttatc cgcacaccgg aatcccggtt 744961 tcagcttccg aaagaccctg aaacgccaat tattatggtc gggccaggca cgggagtcgc 745021 gccatttcgc ggtttccttc aagcccgcga tgttttaaag cgggagggca aaacgctcgg 745081 tgaggctcat ctctattttg gatgcaggaa cgatcgggat tttatttacc gagatgagct 745141 tgagcggttt gaaaaagacg gaatcgtcac tgtccacaca gccttttccc gaaaagaggg 745201 catgccgaaa acatatgtcc agcatctcat ggctgaccaa gcagatacat taatatcaat 745261 ccttgaccgc ggtggcaggc tttatgtatg cggtgatggc agcaaaatgg ccccggatgt 745321 ggaggcggca cttcaaaaag cgtatcaggc tgtccatgga accggggaac aagaagcgca 745381 aaactggctg agacatctgc aggataccgg tatgtacgct aaggatgtct gggcagggat 745441 atagataaag aagactggag acatccagtc tttttagtcc tttcgaaaaa atggtgatcg 745501 cgctaaacat tgatgcatac aataacttca gtccgccgga agggcgggct gtctgcaaaa 745561 cctatttttc gtttttgcta gtttatgtta ttcttatact cggtatctat ttcttttttc 745621 aaaggcacac atgacaaaag aaatcctttt tttatttccg agaaaaaaat gtgaaacgaa 745681 atgaaggttt ctttcgtcca gtgattggtt tccaaatggt tgtaataaaa atgatatggt 745741 gcgaaacata aatattccgg cttgccgcgg tgtatttatt gttgtgtgat gccttgattt 745801 tgtttggaaa gaaggaattg gaaggcagga tataaagagc aggtaaatat gaatgaagaa 745861 cttaaagtgt ttaagaaagt agaggttgcc atgaagaaac ttttttctta caaacttagc 745921 ttttttgtgc tggctgttat actgttttgg gcaaaaacgt atttatccta caagactgag 745981 tttaatcttg gggtaaaagg cacaactcag gagatcctcc tgatatttaa cccattctca 746041 agcgccgtct tctttttagg actggctttg ctggcgaaag ggcgtaaatc agccattatt 746101 atgctgatta tcgatttctt gatgacattt gtgttatatg caaatatttt attctatcgt 746161 ttctttgacg atttcttgac gttcccgaac attaaacagt ccggaaacgt tggaaacatg 746221 ggagacggga ttttcagtat catggccggt catgatattt tctatttctt agatattatc 746281 attttgattg cggtattgat ctggagacct gaattaaaag aatacaaaat gaaaaaacgc 746341 tttgcatctt tagtgatcct ttctgggatc gcactgtttt tcatcaacct gcactatgcg 746401 gaaaaagacc gtccgcaact gctgacaaga acgtttgacc gcaattatat tgtgaaatat 746461 ttaggtttat acaactacac catttatgac ggtgtacaga cggctcaaac agagacgcaa 746521 agagcctatg caagcagcga tgatttaaca agtgtcgaga attacacgac gtctcattat 746581 gcgaaaccaa acgccgagta cttcggctct gccaaaggca aaaatatcat taaaattcac 746641 ctcgaaagct tccagtcatt cctgattgac tacaagctaa acggtgaaga ggtgacgcct 746701 ttcttaaata aacttgcgca cggcggggaa gatgtgacgt attttgataa cttcttccat 746761 cagacaggcc agggaaaaac atctgatgcc gagctgacaa tggataactc gatcttcggt 746821 cttcctgaag gctccgcgtt tgtgacgaaa ggcgaaaaca cctaccagtc gcttcctgcg 746881 attttagacc agaaggaagg ctatacaagc gccgtcctgc atggtgatta caaatcgttc 746941 tggaaccgtg accagattta caaacatatc ggatatgaca agttcttcga cgcaagcacg 747001 tatgatatgt cagatgaaaa tgtgattaat atggggctta aggataagcc gttctttaca 747061 gaatcgattc caaagcttga atctcttaaa cagccatttt atgcgcattt gattacattg 747121 acaaaccatt atccgtttaa ccttgatgaa aaagacgcgt ctcttaaaaa agcgacaaca 747181 ggcgataaca cagttgacag ctacttccag acagcgcgtt accttgacga agcgcttgag 747241 caattcttca aggagctgaa ggaagccggc ctgtatgaca actcagtcat catgatttac 747301 ggtgaccata acggtatttc tgaaaaccat aaccgagcga tgaaagagat tcttggaaaa 747361 gagatcacag attatcaaaa cgcacagaac cagcgtgtgc cgctgatgat ccgcgttcct 747421 ggcaaaaaag gcggagtgaa ccatacgtat ggcggcgaaa ttgacgtcat gccgacactt 747481 ctgcacttag aaggaattga ttctcagaaa tatatcaact ttggtactga tttattctct 747541 aaagaccacg acgatacggt ggcattcaga aacggagact tcgtaacgcc gaagtacaca 747601 tcagtcgaca atatcattta cgatacgaag acaggtgaaa aactgaaagc gaatgaagaa 747661 acgaagaatc tgaaaacaag agtgaaccag cagctgagcc tttcagacag tgtcctgtac 747721 aaagacttgc tgaggttcca taaactaaat gatttcaaag ccgttgatcc gtcagactat 747781 cattacggca aggagaaaga aatcaaataa gatgaaaaag agccttgagc gggcgcattg 747841 ccttcgctca aggctctttt tttggttata caaccaactt gaaaaaatag attccatttg 747901 gtcaccaagg ctggctttct ctcatatcat tacagtagat tttgaaaccg gattgaaatc 747961 ggacaaatta tcggggaaat gccttgatag attgtgaaga tgtaccaggt ttcgaactca 748021 atattcatag agatgagggg tagagatgaa agcggtcatt ctctgcggcg gaaaaggaac 748081 gagaatgagt gaagtcacga atgacattcc taaaccgctc gccatgatag gcggcaaacc 748141 gattctatgg catattatga aaatttatca gtactacgga gtaaacgagt ttattctgct 748201 tttgggctat aaaggagaaa aaatcaagga atactttctc gactatgaat ggaagcacaa 748261 cagcctgaca ctcgacagct ctacgggaga ggtacagatg ctggggcagc ctgaaacgtg 748321 gaaaattacg tttttggaga ctggggtaga tacgctgaca gccggaagaa tcttgcaggc 748381 gaaagactat atcggtgatg aaacatttct gctcacctat ggagacgggc tggccaatat 748441 caatcttttc catctcatca gctatcatca gacaaaaggt gctgccgcga ctgtcaccgg 748501 cattgacaaa gtctcgcagt ttggcacctt gacagttgag gatggcatgg cgaaaacatt 748561 ttctgagaag acatcaagtg atggaatcat caacggcgga ttcttcgttc ttagtccaaa 748621 ggttttcgat tatttgccga aggacgggaa cacgatgttc gaagatgaac cgctgaagaa 748681 ccttgccaaa gatggggagc ttgctgtgta ccgccattac ggattttgga cggccatcga 748741 tacgtataaa aatctcttag aagtcaacaa aatgtggaat caaggacaac aagtatggaa 748801 ggtatggtga attgatttga gtttctggaa aaataaaaac gtatttgtca cgggatgcac 748861 aggtctttta ggaagctatt tggtgaaaga gctgatcgaa cagggcgcaa acgttacggg 748921 gctagtcagg gatcatgtgc ctcaatccaa tctttatcag ggagaacata tcaagaaaat 748981 gaacatcgtg cggggctctc ttgaggactt ggctgtgatt gaacgcgcgc ttggcgagta 749041 tgagatcgac acagtctttc atcttgctgc acaagcgatt gtcggcgtgg caaaccgcaa 749101 cccgatttct acctttgaag cgaatatcct cggcacctgg aatattctcg aagcctgccg 749161 caagcatccg ttaattaagc gggtcattgt cgcttcaagt gataaagctt acggcgatca 749221 agaaaacctt ccatacgatg aaaacatgcc gctgcaaggc aagcacccgt acgacgtctc 749281 aaaaagctgc gcagatctga tcagccacac ctattttcac acgtacgggc ttccggtctg 749341 cattacgcgc tgcggaaact tatacggcgg cggagatttg aacttcaacc gcatcattcc 749401 tcagacgatt cagcttgtgc tgaacgggga agcgccggaa atccgaagcg acggcacatt 749461 tgtacgggac tacttctata ttgaagacgc cgttcaggct tatctgcttc ttgcagaaaa 749521 aatggaagaa aacaatcttg ccggagaggc ctttaacttc agcaatgaga tccagctgac 749581 cgtacttgaa ctggtagaga aaatattaaa gaaaatgaac agtaatctga aacctaaggt 749641 gctgaatcag ggaagcaatg aaatcaaaca tcaatattta tccgcggaaa aagcaagaaa 749701 gctgctgaat tggacaccgg cctacactat tgatgaggga cttgaaaaaa cgattgagtg 749761 gtatacggaa ttcttcaaaa agtaatgtga aacgaggtga acaagactgt gaccagcgcg 749821 tattgcaccg ttttatcaaa aggaagatta tatcaggcag tcgctttgtt taagtcgtta 749881 gagcaagttg atcaagacag tcccattttt atactttgca tggatgaaga tacgcaccgc 749941 gtgttacaga agctgaagat gaagcagctg aaccttgtgc cggtggccgc tcttgaaaat 750001 gaattgctgc tgaagctgaa ggaaactaga gatcaaagtg agtattgctg gacgatgaag 750061 ccgatctttc tgcaagctgt gctgaacagc aatcctgagc tggagcgtgt gacgtatatt 750121 gacggggatc tctttttcta tgcagatcca tcgccgattt ttgaaaacca gccggactgc 750181 tcggtgttgc tttcacgagg ggatattgta atcccttctt ttgagaaaga gcagattgac 750241 atgctgcagc gtcttttagg cagatataat tccgggttta tcagcttcaa gcatgatgat 750301 gcaggcacgg attgcttgga gtggtggaag gaacgctgtc ttgaggaatg caaaaatgca 750361 ccgggtgaag ggaaattcgg tgatcagggc tatttggatt atatgtctga gctgtttccg 750421 aatgtgtgtg acattacaac acccggcgtg aacatcggcc attggaatta tggacagcat 750481 acgttttcct ggaaagatgg ccggatcgtg ctggaggatg gcagtccgct gatcttttat 750541 catttcagcg gataccgaat cgtcagcatc aatgaaatca aacagattca tgaaacaacc 750601 cgcacagatc tgccgtttgt gcatgaactg tatcaagaga cactgccgca tatcattcag 750661 cacatgcaaa cgttagaccc tgaatttaac ggttttgctt caaaagatga caacaaataa 750721 atgagtaaat acaggaagtg aaaatgaagt gaaagcaagc gttattattc ctgcatataa 750781 ttcgaaggag cgtctttaca acagccttct gtcattaaac cagcaggagt gcgatgaaga 750841 atttgaagtc attgtagcgg acaatggctc tgaggacggg acgctctcga tgcttgagtc 750901 atttcaagct gattttccgc tgatctttac acggattaaa gaaaacaggg gcattgcgta 750961 cggacgaaat caggcgcttc gcaatgccag aggagacatc ctgattttcc atgacagcga 751021 tatgcttgcg gcaaaggacc ttgtggcaaa acatattaaa gcccatgaga acgaagagaa 751081 tctcgtcgtg tgcgggttgt tttggaaacg gatctacagt ttttactatg aacgatttga 751141 agaagaacat aaggaacagc tcgcaaagct cacaggtgaa atgccgaaga aagacaaaca 751201 aaagctgctg gaggaagcgg acatcaaaaa cggaagcttt cttgataaaa gctttgacct 751261 cgataccgac tttatagacg tgctcaagaa gattttagat gagtacggcg atgacttgaa 751321 aggctatcat atgccatggc gcttttttat cacgaataat tcctctgtga aacgcaagca 751381 tgtggttgac ctcggtttat ttgacgaagg cattgtgcgg tacgggtttg aggattatga 751441 cctcgggatc aggcttcatc aggccggatt gaccttcagg cttcgccgtg atattgtcag 751501 tgttcatcag gaacatccaa gcaattgtaa gtctgtagac gatattcggg caaacattgc 751561 ctatatgtgc gataaataca ataacatccg ctccttagac gttcatctcg cttttaatgg 751621 gccgttcccg cctgacatga cgaacagaat catggctgat attcaaaagc tgctggaatc 751681 acagaaatat gatatgctgc tgaatctgtt tcttgagctt ctgcatgttg ttaaagagcg 751741 caacattgat ccggattggc gaaagaaatc cccaagggtg acggcgaaaa gctttgattt 751801 gcaaactgtc cgcaagcttc tgcctaaggc gaagaaaaag ctaggcgtga acgattttgc 751861 caacgcactg tatgcgcttg tcaacgattt gctgcacgtg gatcttagat cattggatgt 751921 ggtataagtg agtacatttc atttttcaac gatagtgtca aggacacata tctttaagct 751981 catgcctatg attcattctc tccatgagca ttgcgatgat tttcatttat atgtgctgtg 752041 tgtcgaccag aaagcgtatg aattgcttca gcacgttcca tgggagcatg taacctttgt 752101 gcagctgcat gaaatggaag acccggagct gttgaaagcg aaaagcaaca gaacgtttca 752161 tgaatattgc tggacgttaa agcccgcctt tttgtttcat gtgatgagca agtgggatga 752221 cgctgaatac tttgcccata tggatacgga tctatttttc ttttctgatc cggcacgtat 752281 ttttgcagaa aacccaacgg cgtctctgta tttgactgat catcgtaatt cgccgcgctt 752341 catgtcctac tacgaccgaa ccggacgctt taatacaggc tttgtcggcg ccggtaatac 752401 aaaggaagca tatgaagcgg tgtggcagtg gagacaggac tgtattgaat tttgcacggt 752461 cgaaatggat acggaacgaa agacatatgg tgatcaaaga tatgtggaga aatggccgga 752521 gcagtttaaa ggtgttcatg ttgtcaaatc cataggagcc aatacagcgc tttggaatat 752581 cgaaaactat aaggtcgggc aaaaggacgg ccgcgtgtat atagatgaaa cgccgctgat 752641 tttctatcat ttctctgggt ttacgctggt gacagaaaaa gagtttaatc tttgctggta 752701 ctaccggatt gaagacgaag cgacaattaa gatgatttat atgccctata tattaaatct 752761 gaaaagatgg attgatgaaa tacagtcggc gtttccggac tttgcggatg gctttatccc 752821 gaagcacgca gtgcctgaca ctcattttat ccagctggat taaaaaaccc cctgccgcct 752881 ggcaggggtt ttttcagcta tgccattctc tcagcttctg gtcacttggc aataggaagg 752941 caaggatgcc gaggacaggg agaaaggcaa tggcgatcat cgtcggggtc agtcccgcgg 753001 catcaatcag agcgcccagc gccacagcgc cgattgcgcc catcccgaag gcaagcccga 753061 cggttaaacc ggacattgtg ccgatttttc caggaactag ctcctgtgcg tagacgaccg 753121 ttacagaaaa gctcgacatc agaaccaagc caatcaatgc gagcacgccg taggcgagaa 753181 ccgggccggc aaatggcagc acaatcgcca gcggcgccga gcataacagc gaaccgagga 753241 taacgaagcg ttttccaaaa cggtctgcaa gcgggccgcc gagaaacgtg ccgatcgcgc 753301 cgaacagcaa gaagacaaaa atatagcttt gtgcctgctg aatgcttacg tgataggtat 753361 ccatcgcgta aaacgtgtaa aagttaccga tcgcactcgt ataccaagaa cgagcaaaaa 753421 tgagaaatat aataataata agagcagata caacagattt ggtgatggcc gtgttttcag 753481 ccgttttctt ttgcttgcct gatttctggg caaggctgcc gagacgtgag gcgtaccatt 753541 tcgcaatata catgagaaac ataacagcaa gcgcggcgac aagcgtgaac caaacagcgc 753601 cgaattgccc gagcggcaca aggatcagcg cggtgatcag cggtgccatc gcctggcctg 753661 agtttccgcc cacctgataa atcgattggg cgagcccgcg ttttgtgccg gcggccatat 753721 acgccacacg ggagccctcc ggatggaaaa tggccgagcc taatccaatg aaaaacacac 753781 agcataagat cgttatgaat gacggggcaa atgcaaggcc caaaatgcca agcatgctgg 753841 cggtcaaacc gactggcagc gcatacggcc gcggccgttt atcggtatac cagccgacaa 753901 caggctgcat gacggatgac accatgttta atgtgaaagc aatgatgccg agctgtgtaa 753961 acgtcaggct catggagcgt tccaaaatag ggaacatggc cggaatcaca gcctgaagcg 754021 aatcgttgag catatggcaa attccgataa taatcaaaat cggatacacc gtggtgcctg 754081 gtttttgaac tgttttttct tttaacgggg cggcgatagc cattgagtct cctccttaca 754141 tatataacca aagcatacca ccatattatt cataaggtga agaatttatc aagaggaaaa 754201 aagattctta tgaaagaaat accgtcagcc tgattagcag ctgacggtat tttcgatatt 754261 caaaatgtga tatagctctt caagcttacg aatctcatag gttggtatga tctctggcac 754321 attcggcttc atgtcagggt tcatccagca agtatcaagc ccggcgagct gtccgccttt 754381 gatatcagca gttagtgaat ccccgatgat taatgtgtgc tctgctgaaa attgaggaat 754441 ccgttcaaac acgtaattga aatattcctt catcggcttt tggaagccgg tgtcttcaga 754501 aacgaaaatg tccttgaaga atggaaataa tcctgaatca cggagacgct tatattgtgt 754561 gtgagacacg ccgtttgtca cgatgtacaa atcaaactgt tgctgcagat ttgagatgag 754621 atcaaatgca ccgtcaataa gctgatgtcc ttcttcaaga aagcggcggt atttttgctc 754681 aagcaaagcg ccgtccgctt cgtaaccgta ctccttgagc aaagcggaaa aacgtgtgtt 754741 tacgacttca tcccgtgtca tcttaccttc ttcaaaggct ctccagagac cttgattgat 754801 ggttttatac tgcgccttca tgtcatttgt taaaggaatg ttctgatctt caaacagcaa 754861 acgcagggct aaagcttctg ccgcttgaaa atcaaggatg gtatcatcta catcaaataa 754921 taaagtgcgg tatcgcttca tctgtgtgtc tccctttctc atatgtattc aaagtatagc 754981 acataaaaaa aggaaaaagc cggcgggtga ggcaccgccg gctgaaaaga gattatttgt 755041 ttaataagct gtgttttctc gaatatagga agtaaaccag cgttccgaca gcgatccaga 755101 tgacaaatga aagccatgtg acgccgggaa ggctgtacat gaaccaaagg cagatgcctg 755161 cgctgataat cggcacaacc ggaacgaatg gcactctgaa ggacgctttg atttcaggat 755221 gtttctttct taacacaatg acagcaatgg aaatgaccgt aaacgcggca agtgttccca 755281 tgttcaccag atgggccagc gttccgaggt taataaagcc ggcgattccc gctgcaacga 755341 tccctgtcag ccatgtgttg cggaacgggg ttttaaatga cggatgaacc tttgcgaaca 755401 atccaggcag aaggccgtct ctgctcatgg caaatgtcaa gcggacctgt gcgtacagca 755461 aagcgagcat caccgtcgta atcccgataa tcgcaccgac agaaataatt ccggcaacag 755521 cgtcctgtcc gacgaatttc agcgcaaagg atacaggatc tccgacattc aatttggcat 755581 aaggcatcat gcctgtcagc acaagcgata ccgcgatgta cagaaccgta cagacggcta 755641 gagctgaaat aatgccgacg ggcatgtttt tttgcggatt tttcacttcc tctgatgcgt 755701 tagaaaccgc gtcaaaccca aggtacgcga agaatacagt ggcagcgcta agtatgacgc 755761 ctttcatccc gaatggcata aaaggagacc agttatccgg tttcacatag ccgatgccga 755821 caataatgaa caataatatg atcgcgattt tcatcagtac gatgacgttg ttaaagcgtg 755881 tgctttcctt gacgcctctg ctgacaatcg cagtgatgag gagaatgatc accgcagccg 755941 gaaggttaaa tacggcgccc gccatgcttc ccggcgctcc tgtcagtgca gccggaatat 756001 gaagattgaa gccggcaagc agtgattgaa agtatgaaga ccagccggtg gcaaccgccg 756061 acagtgcaat gacatattca agcatgagat cccatccgat caaaaaggcg agcagctctc 756121 caagtgtcac gtatgagtat gagtacacgc ttcccgaaat cggaatggaa gacgaaaact 756181 cagcataaca gaaagcagcc agcgcacagg cgagccccgc taaaataaac gatatgatga 756241 gggcgggacc tgcaccggtc gctgccactg ttcctgtaat gacaaaaatc cctgtaccga 756301 tgacacaacc gataccgagc aaggttaaat caaatgcgct taacgtacgg gcaaggcttt 756361 ttgacttgct ctgcgcactc aatgtttcaa gcggtttttt tctaaataat gaactcatca 756421 aaagttcctc ctagaaatat tcaaaatatt ctaatcatta tatgcagttc ttgttgtatt 756481 atattgtcga aatttgacgt agtcaataaa atatttttct gctttaaatg atagaagcga 756541 aacagcgttg tcgtatcata ggatagtaat ttttactaat cgtatattca attttatgca 756601 agatgaaccg atagaaaaaa tagattcgcc catattttga tttgcggtta taaaggagat 756661 gctgaccatg tttcaatatg aagagttgaa taaacagttt atcggcggga aatggcagga 756721 gggcagcagc ccaaatgtat tggaaaacaa aaatccttat actcaaaaaa cattcacaac 756781 attccgtaaa gcgactgctg acgatgtaga tgaagcgtat cgggcagcgg cgctggcaaa 756841 gaaaaaatgg gatgcggtca acccgttcga gaaaagaacc attttagaaa aagccgtcac 756901 gtatattgaa gaaaatgaag aagccattat ttatttgatt atggaggagc taggcggtac 756961 aaggctcaaa gcagcttttg aaatcggtct tgtcaaaaac atcataaaag aagcggcaac 757021 gttcccaatc cgcatggagg ggaaaattct tccgtcaaca atagatggca aggaaaacag 757081 attatatcgc gtgccggcag gcgttgtcgg tgtcatcagt ccgtttaact tcccattctt 757141 tttatctatg aaatcagtgg cgcctgcact cggagccggc aatggcgttg tgctaaagcc 757201 gcatgaggaa acgccgattt gcggcggaac gctgattgcg aaaatttttg agaacgcggg 757261 aattccagcg gggctgctga atgttgttgt cacagacatt gctgaaatcg gcgacagctt 757321 cgttgagcat ccagtgccgc ggatcatctc atttaccggt tctacgaaag tcggcagcta 757381 catcggacag cttgcgatga agcattttaa aaagccgctt cttgagcttg gcgggaacag 757441 cgccttcatc gtacttgagg atgcagatat agaatatgcg gtcaatgcgg cggtgttcag 757501 ccgatttaca catcaagggc agatttgcat gtcagccaac cgcgtgcttg ttcattcttc 757561 tatttatgac aagttccttg agctgtacca ggcaaaagtg gaatcgctga aagtcggcga 757621 cccaatggac cctgatacga ttatcgggcc attaatcaac agcagacaga cggacgggct 757681 gatgaagact gtagagcaag caattgaaga aggcgctgta ccagtgaagc ttggcggatt 757741 taacgggacg atcgtggaac cgacgatctt aaaagacgtc aaaccgttca tgagcattgc 757801 caaggaagag ctgttcggac cagtcgtctc ctttatgaag tttgattcag aagacgaagc 757861 ggtggatatc gcaaacgaaa ccccgtttgg cttgagcggt gccgtacata cgtcaaatct 757921 tgagcgcggc gtggcttttg cgaaacgcat tgaaacaggc atgattcacg tcaatgacac 757981 gaccatcaat gatgaaccga atgtagcctt cggcggtgaa aagcaatcag gcctcggccg 758041 tttaaacggt gagtggagcc tcgaagaatt tacaacgctg aaatggatct cggtccagca 758101 cgaaaaacgc agcttccctt attaatgaaa aggagtgaat ggaattgacc ataaatacgg 758161 aaaaagaaac cgcagatatt ctggacgcat ttatcaaagt agccccttat ttaaacagcc 758221 tggttcagga tgatattaca atcggcattt atgatacgga aaaactgctc gtgaatatac 758281 cggccaaaac cttttcgctg aacgtaaaag ccggcgatcc gctgcaggaa ggggatatca 758341 tcacagatgc catccgcagc aatcagaaga agacgagcat ggttccgaaa gaattgttcg 758401 gcttcccatt gatcgcgcgt gccatcccgc tgcacgacga gaatggaaga gtcattggag 758461 gcgtcggcct cggaacgagc cttgaggagt cgtcaaagct gcatgatgtc gcggaaagct 758521 tatcagctgt tgttgaacaa acagccgcgg ctatttccga catttctgaa tcaattaacg 758581 ggttttcaac tcaaatgtcg ggcatttcct ctcaggcgaa aaaagtaagc gaaagcgccg 758641 gtgaaatcgc cgatatttca gtaactgtta aaggcatctc ggaccaaagc aatctgctcg 758701 gcttgaacgc cgcgatcgaa gcggcaagag caggggagtc cggaaaagga ttctctgtcg 758761 tcgcagatga gatcagaaag ctagcgacgc attcaaaaga aaatgtcggc caaattgacc 758821 agattacgaa aaaaatccac agcctgctga aagggctgga ggaatccatt gagtcgatta 758881 accagcatac agacggacaa gccgctgctg ttgaacaaat ttccgccacg atgcaggaga 758941 tttcaggaag cgcgcagcat cttgcgaaaa tggccgaaaa agcgcttgag gaagagtaag 759001 agaccgggga caaacatccc cggtcttttt cttatcctgc atttccatga aattcgtctg 759061 acgttttact agttttattc cagcggctga tttaaaatgt acacatgaac ttacgtgagg 759121 attgatagga accatgagca tattaaaagc ggaaaatctt tataaaacat acggagataa 759181 aacattattt gaccatatct cctttcatat tgaagagaat gagagaatcg gattaatcgg 759241 gccgaacgga acaggaaaat caacgctgtt gaaagtgatt gccggcttgg aatctatcga 759301 agaaggagaa atcacgaaat ccggaagcgt gcaggtcgaa tttcttcatc aagacccgga 759361 gctgcctgcg gggcaaacag tgctggagca tatctattcc ggtgaatcgg ctgtgatgaa 759421 aaccttgcgt gaatatgaaa aagcgctgta tgaactgggg aaagatcccg aaaatgaaca 759481 gcgccagaaa cacctgctgg cagcacaagc gaaaatggac gcgaacaatg catgggatgc 759541 aaacaccttg gcaaaaaccg tattgtctaa gctgggcgtc aacgacgtaa caaaaccggt 759601 caatgagctc tcaggcggcc agaaaaaacg ggtggccatt gccaaaaact taattcagcc 759661 cgctgatttg ctcattttgg acgagccgac aaaccatttg gataatgaaa cgattgagtg 759721 gcttgaaggg tatttaagcc aatatcccgg cgccgtcatg ctggtgacgc acgatagata 759781 tttcttaaac cgtgtcacca accgcattta tgagcttgaa agaggcagcc tctacactta 759841 caaaggcaac tatgaagtgt ttttagaaaa acgcgcggaa cgggaagcgc aggctgagca 759901 aaaggaaacg aagcggcaaa acctgctgcg ccgcgaactg gcttggctca gacgaggagc 759961 gaaagcccgc tccacaaaac aaaaagcgag aattgaccgg gtagagacgc ttaaagagca 760021 gacaggccct cagtcatcag gttcactcga ttttgccatt ggctcgcacc gtctcggaaa 760081 acaggttatt gaagcggaga acgtcatgat cgcttatgac ggccgcatgc tcgtcgaccg 760141 ttttaatgaa cttgtcatac caggtgaacg gatcgggatc atcgggccga acggcatcgg 760201 gaaaacaacg ctgttaaatg cccttgccgg ccgtcatacg ccggacggag gcgatattac 760261 gatcggacag acggtcagaa tcggctacta tactcaggat catagtgaaa tgaacggtga 760321 gttaaaagtc attgactata taaaagaaac ggcggaggtc gtaaaaacgg cagatggcga 760381 tatgattaca gctgaacaaa tgctcgagcg tttcctcttc ccgcgttcga tgcagcagac 760441 gtatatccgc aagctgtccg gcggggaaaa acgccgttta tacttgcttc aggttctcat 760501 gcaggagccg aatgtcctgt ttctcgatga gccgacgaac gatttggata ctgaaacatt 760561 aagcgttctt gaggattata ttgaccagtt cccaggcgtc gtcatcaccg tatcccatga 760621 ccgctatttc cttgaccgcg tcgtcgaccg tttgattgta tttgaaggaa atggtgtcat 760681 ttcccgcttt caaggctcct atagcgacta tatggaggag tcaaaagcga aaaaagcggc 760741 cccaaaaccg gcagctgagg aaaaaacggc tgaagccgag ccgaagaaaa aacggaaaaa 760801 gctttcttac aaagaccagt tggaatggga cggcatcgaa gataaaattg cccagctgga 760861 agaaaagcat gaacagcttg aagctgacat cgccgcagca ggcagtgatt ttggcaaaat 760921 ccaagagctg atggccgagc aggcgaaaac ggcggaagag cttgaggctg cgatggaccg 760981 ctggacagaa ttgtccctca tgatcgaaga actggaaagc taaaaagcgt ggccgcagca 761041 ggccgcgctt tttttcacat aatggacaaa aacgaaccgg cctgcttatg ttaggataaa 761101 gttgtgtgtc agcggcacat ggaaaactaa cggagatgat gaagtatgac atgggcgatc 761161 gtgatgttaa ttctcatgag tctggtgaaa atcgtattaa cctgtcttcc tacaggcgtc 761221 atagaatggc tgctcggcaa atttgaagtg cacgccaagc tgagtgacga aaatgcgagt 761281 ctctctctag atggaaaacg cctcgagggt gcagagaagc agaaagtgat tgatcaattt 761341 aacgaagcta tcttcctgga aaaatattat atctatccag gtgatgaaga gcgttattta 761401 catccggaaa acggcggcac gcctctggtg atagatacaa aaaaaggaaa aaaagacgtg 761461 aagctgttcg tgtaccgcta cgacgaccat atcgacgtcg tgaaacagta caagaagaaa 761521 gtgatcgcgt atcgagtgct ttctgaaagc cttcaaaaag agtctctgtc agtggcggga 761581 agtttagctt aaacaggaaa gtgaaagacg ggtgctgtat gctgctcgtc ttttttattg 761641 ttttttaaaa cttaacgttt acgttaaggt tcaaaaggtg tataatggta acagaaacgg 761701 cgaaggggga tttaccttgg aatggatgaa gattgatcaa gtggccaaaa gaagcgggct 761761 gacaaagcgg accatccggt tttatgaaga aatcggcttg attccggcgc cgaaacggac 761821 agacggcggt gtaaggcttt attcagagga tgatatggag gagcttgaga aagtcatcag 761881 cacaaaagag gtgctcggtt tttcccttca ggagcttcag catttcatgg aaaccagccg 761941 ccagctagag ttaaacaaag aggggtattt gttgtcactg gatcctaagg aacggaaaga 762001 aaaactggag gaaattcagg aaaccctgaa tcaccagctg gatttgattg atgagaaaat 762061 ccgcacattc caaagcttta aagaacgcct gcagggcatg aaaggcaaag cggaacgcgc 762121 cattcaatca atcgaatgaa aagtttgtta aacgctattt ttgtagcgtt tcttttaatg 762181 gaataaagat ggaggttagg tcaaatggat aagacaacac aagtgaatca gaaaacgggt 762241 ttgctcagcc agccaaaagc ggtatgggct gtcgcgtttg cctgtgtgat ttcttttatg 762301 ggaatcgggc tggtcgatcc aattcttccg gccattgccg cacaattgca tgcttcacct 762361 agtgaagtat cactcttgtt tacaagttat ttgcttgtaa ccggatttat gatgtttttc 762421 tcaggagcca tttccagccg catcggcgcg aaatggacat taattctcgg acttattttt 762481 attattgtgt ttgcggggct tggcggcagc tcaagctcaa tcgctcagtt agtcggctat 762541 cgcggcggct ggggattagg gaatgctttg tttatttcaa cagcgcttgc ggtcatcgtt 762601 ggcgtgtcag tcggcggcag cgcccaagcg attattttgt atgaggccgc gctcggtctc 762661 gggatttctg tcgggccgct tgcaggcgga gagctcggaa gcatttcatg gcgcgcaccg 762721 ttttttggag tatctgtcct gatgtttatt gcgttaatcg cgatttcttt catgcttccg 762781 aagctgccga aaccggcgaa acgcgtcggt gtgtttgatg cgatgaaggc actcaaatat 762841 aaaggcctgc tgacaatggc ggtatcggca ttcctataca actttggatt ttttattttg 762901 ctagcttatt ctccgttcgt actggattta gatgaacacg gtcttggata tgtcttcttc 762961 ggctggggcc ttctgctggc gattacgtca gtctttacgg cgccgctcgt gcacaaagcg 763021 ctgggcacag tgcgttcgct agtcgttctc tttatcgcct ttgcggccat tctcgttatt 763081 atggggatct ggacagacca tcagactttg attattacat gtatcgttgt cgctggtgct 763141 gtcctcggta tggtgaatac gatcatgaca accgctgtga tgggttctgc gccggttgaa 763201 cgttcaatcg cgtcttcagc ctacagctca gtccgcttca tcggcggcgc gctcgccccg 763261 tggattgcag gaatgctgtc agaacacttt actgcaagca caccatatac agtaggcgga 763321 atcgtcgttt ttgtcggcat gcttgtcctt ctcatgggac gtaaacatct tgctggaatt 763381 aaggcggggc attaataacg aaagacactg cgcatatgca gtgtcttttt attcgttata 763441 atgcatcata atcgaattgg tgcaggaaag gacaaccttt atgacacaat tttactattt 763501 tccggctgaa aactcccttt agaaaccggt tttttcggtc agcaagaacg gcgttcgcgg 763561 aaagggcatc cgcttcggtc aggcattgat gcggctggga tttatcttgc agaagctgag 763621 aatgtgtccg ttcatttacg attgccattt cagtgatggt tcatgctgta gaggggacgt 763681 ttgccatgga taaggcaaaa cctgacgaat atgatcagaa atgtttagaa acgctctatc 763741 aatacataca cagcgtcatg aaaaacagct tttctcggtc gagtggttta ccgcttggga 763801 agatgaggag gattttgagc tgtctgccaa aagagagctg acacttgatg aattcacatc 763861 tccattgcag ctcattttaa aagacagaga gcttttgaga atcgttcaga aaaaatggca 763921 gtaaaaaacc cgccctttag caggcgggtt tttttataaa ttaaagcact ttcgtcgtcc 763981 aagactcgca gttccacgtt tctgtcgcaa tatccatata aaagtctggc tcgtgggaaa 764041 tgagcagaat ggagccttta tattctttca gggcgcgctt gagctcttcc ttggcatcgg 764101 catccaagtg gtttgtcggc tcatcgagca ccagcaggtt tgtttctgag ttgattagct 764161 tgcacaatct gactttcgct ttttcgcctc cgcttaatac ggagacgcgg ctttcgatat 764221 gctttgtcgt cagcccgcat tttgccagag cggcacggat ttcatactgc gtataagaag 764281 ggaattcgct ccatacttct tcgatgcacg tattgttgtt tgtttccttg acctcttgct 764341 cgaaatagcc ggtatagatg tgctcaccgc gttcaacaga gccttcgagc ggctggattt 764401 caccaagcaa acttttcagc aatgtcgttt ttccgatccc attcgcgccg taaagggcga 764461 ttttttggcc gcgctccatg cggaggttga gcggacggga cagcggggaa tcgtaaccga 764521 tcacgagatc cttcgtttca aaaatcagct tgcctgacgt tctcgccggc ttaaagtgga 764581 attccggctt tggcttttct gccgcaagct cgatcatatc catcttatcg agtttctttt 764641 ggcgggacat cgccatgttt ctcgtgctga cacgcgcttt gttgcgggcg acgaaatcct 764701 tcagctccgc gacttcctgc tgctgctttt tgtaggccgc ttcaagctgc tgttttttca 764761 cctcgtagac ttccataaac tgatggtagt cgccgacata acgtgtcagc tcttgatttt 764821 caacgtgata aatcaggttg atgacactat tcaagaacgg aatatcgtgg gaaatcagga 764881 tgaacgcgtt ctcgtattcc tgcaggtagc gtttcagcca ttcaatatgc tgttcatcaa 764941 gatagttggt cggctcatcg agaagcagaa tttccggctt ttcaaggaga agcttagcga 765001 gaaggacctt tgtgcgctgt ccgccgctca aatcggtgac atctcgctct aaaccgatat 765061 cgctcaaacc gagaccgcgg gcgatttctt ccaccttgga atcaatgaca taaaaatcat 765121 tgtttgtcag cgcgtcttga atgacgccga cttcttcaag cagcttctcg agctcgtcgg 765181 gatcagcctc gcccattttg ttgtaaatct cgttcatttc ctcttccatc gcaaataaat 765241 aatggaatgc gtctttcagg acgtcgcgaa tggattttcc tttttccagc acggtatgct 765301 gatcaaggta tccgacacgg acattttttg accattcgac ttttccctca tcaggttcaa 765361 gctttccggt aataatattc atgaaggttg attttccttc accgtttgcg ccgatcaagc 765421 cgacgtgctc gccttttaac aggcggaagg aaacgttatt aaaaatggcc cggtccccga 765481 aaccgtggct taaatccttt acagataaaa tactcatgtt tacacctcta tcgttatcaa 765541 acacgcacaa tcggcgtgta atattcaccc ttttgattat aaaggaggat tcggaatgtt 765601 gaaaggtata ggaaagaaaa agaaaaattg cgttccgggc gaggttttga gatactatgg 765661 aatagatttc aggaattgag gagaacaaaa tgacgcaaac ttggccattt ttacataatg 765721 cacaatcatt tatacaagag aattggaatg cttccggctt tcaaaagcca acccctgttc 765781 aggagcaggc agcccagctg atcatggacg gaaaggatgt cattgcagaa tcgccgacag 765841 gcacagggaa gacgctggcg tatgcgctgc cggtcttgga gcggatcaaa ccagagcaaa 765901 agcatccgca ggcggtgatt ttagcgcctt cccgtgagct ggtcatgcag atttttcagg 765961 tgattcagga ttggaaagcg ggctcagagc tgcgcgcggc ttccttaatc ggcggggcga 766021 atgtgaagaa acaggtcgaa aagctgaaga aacatccgca tatcatcgtc ggcacgccag 766081 gcagggtgtt tgaactgatt aaagcgaaga aactcaaaat gcatgaagtg aaaacgatcg 766141 tgcttgatga aacggatcag ctcgtcctgc cggagcatcg cgaaacgatg aagcaaatca 766201 ttaaaacaac attaagagac cgccagcttc tatgtttttc tgccacgctc aaaaaggaaa 766261 cagaggacgt gctccgcgaa ttggcgcaag agcctgaggt gttgaaggtg cagcgaagca 766321 aggcggaggc agggaaagtg aagcatcaat acctgatttg cgaccagcgc gacaaagtga 766381 agctgctgca aaagctgtca aggcttgaag gcatgcaggc actcgtattt gtgagagaca 766441 ttggcaacct gagtgtatat gcggaaaaac tggcatatca ccacgttgaa ctcggcgttt 766501 tgcacagtga agcgaaaaaa atggagcgag cgaaaatcat tgccacattc gaagacggag 766561 agtttcctct tttattggcg actgacattg ccgcacgcgg tttagatatt gaaaacctgc 766621 catacgtgat tcatgctgat attccagatg aagatggcta tgtccacaga tcaggacgaa 766681 caggccgggc cggaaaagaa ggcaacgtgc tgagccttgt gacaaaattg gaggaatcta 766741 agctgaaaaa aatggcgaag aagcttggtg ttgagctgag tgaagctgtg tatgcaggcg 766801 gaaaactgaa gacgaaataa aaagaagggc gaagagccct ttttttgttg taaaataata 766861 gaaaagattt tgcgcggagg tgggaaaatg gcttcaatag acaggtttca agtaatgcag 766921 gagccagagc tgaaaatcct tgaacactgg tttgagaatg aggataccag acggagaatg 766981 gatgggatgc tgctattaga tgagtggtat gcacgagtaa ataaagataa acacgatact 767041 gtcatcatgg cgtatgatgg acagctgccg gcagggatgg tcgttattga gttcggagag 767101 gagcggacat atattggatt gatcgtcaat cctttgtacc ggcttaaagg gtatggaaaa 767161 cagatactgc aaaagctgat gaccgaacct gattttacta gcgtgcgaga atgggtggca 767221 tgcattgaag aagacaatcg aatcagttta gcttgctttc aagcagcagg attcacttta 767281 gaagacacgg aacctgatga agatggtttt cttacgctga ttcttcgcaa ctgatctcat 767341 cgaaacacaa aaggagggca aaaagccctc ccgttttcat cttcattcag ctcggatcac 767401 tgaccttgat cagctgtttc cctttatttt ctcccttaaa taaaccgaga aacgcgtcag 767461 gaatgttttc gaagccttct gtgatggttt cctcgtaatg gagtttacca gccttcagcc 767521 attctgccag ctgttttgct ccctcagaaa aacgatcgga gtagtcgctt acgataaagc 767581 cttgcatcag cgacttcgtt ttaatgagtt ttgattggac acgagggccc atgtcatctg 767641 cttcgctttc tgcgttatag gaagaaatgg cgccgcacac cggaatgcgg gcaaattcat 767701 tgagcagatt catcaccgcg tctgaaatcg gtccgccgac attgtcaaaa tacacatcga 767761 caccgtcagg acaagcgttt tgaagcgctt tttggatatc atccgctgtt ttgtaattga 767821 tggcttcgtc aaactgaagc tcctgtttta aatagtcgat tttttcatca gagcccgcga 767881 tgccgacgac tcgcgcgcct ttgattttgg caatttgccc gactgttgaa ccgacggctc 767941 cggcagctcc tgagacaacc acggtttcgc cttccttcgg gcgtccgatg tccagcaatc 768001 cgaagtatgc tgttaagccg gtcattccca aaatgccgag ataggccgaa gcgggagcaa 768061 ggcttgtatc aatttttcgc aaggcagact cgctcacagc ggaaaattcc tgccagctga 768121 gatttccgat gacgatatcg ccttttttca gatgattccc gtctgacaca acttcagcga 768181 taacccctcc agaaagcgct ttatccaagg cgaacggctc aacatatgac ttcgtatcct 768241 gcatacggcc gcgcatataa gggtcaaccg atacataaag cgttttgaca agcacttccc 768301 cttgcttggg ttcaggaacc ggaatggttt caaagcgaaa gtcttcatga acaggaatac 768361 cttgtggacg tcttgctaat tgaatttgct gctgagatgc tgtcattttc atcctcctat 768421 cacttggttg acaccactgt aacatggaca ggagaggaaa tacaaaaggt aagctggcat 768481 acaaaaaagg ttatagatga gcttatgctt tctacaagct cttttgtttt aaaagttctc 768541 tttagtcatt tatcattatt agaaaacaga acagaaaaag agctcctgta cacctagcta 768601 agattggcta gtgtgtatgt cgattctttt tcatattctt gcaagcatct gcgaggggga 768661 gcttagtcgt tcacattttg ctttcgcatc aatctgcaat agcaaagtct atgcgatttt 768721 tttacatcag caaagatttg ttcaattttt tccttttatg ccgagttttt ctgaaacaga 768781 taattgatgg tactcaacca ttttcttttg gtcaataaag taatgtttac ttattaatta 768841 aacacgcgaa aaagcaaacg aaaacataat taaattttat atatttatta aaagcttata 768901 tgtttattta cctttttttt gaattgtaat tgagaaaatc catatattgc ggacactaat 768961 aaaagaatac ctgctgaaac ataaactaaa cgaactccaa ggaaatctga aatagcccct 769021 atagccagaa ttgaaaacat aaaaatgaac tgtactaaag aagaccttgc agacattata 769081 ttaattcgag tttgctcggt tgttatgttc tgaataagtg tttcttgtgt aagatctctt 769141 aatatataag ccggccccat aaagagaacc aaaattagag ctaagtatga attacttata 769201 aaaccatata ttaaagttaa acttccatat gagacagcgc caattaacat aaaattaatt 769261 aacttatttt gaaatctctc cgacagctta tatattataa atccccctat catcgaacct 769321 aaataatatg ctccattaat aaatccccac catgattctc ctttatgcaa gacttcgtta 769381 acgaaagcta aagagacaga tcctatccaa atcattcctg cccatgactc aattaaatcc 769441 ataataataa ttgttctaag tttcttttgg ctaaataaat accgccaacc acttactata 769501 ctcttattgg gagaattttt ttcacgtatg acagaattag cgtggccatg tggtagacaa 769561 aataaaagag aaagaagaga tgtaaacaac aaaaagatag taagtataat ggtatatccc 769621 tcacctaaaa atgcaattat gagaccacct aaagaccagc ctacaaattg aaaagtttgg 769681 tccactgtag ataataatcc atttgctttt actcttctat caggagagat tatttcccct 769741 ataattgcac tttttaaagg tgagaaccat ccattaaaaa aggaaataca gctaataata 769801 ataaagacta aaatgagagt ttgattagag taagttctta ataaagcata gaacaaacat 769861 attaataaca gcatttgtat caattgagaa ataattattg taagaggcag ttttaatcga 769921 attgttatta acggtaatat agcacttcca aaaatacgaa aaataatact tattaatgtc 769981 accatagagg cgatggttgt cgaattggtc attttaaaca aaaacgaaat cactaccata 770041 gtatatagag aaaaacctaa atttgtagtg gtctggctaa ataaaataga ataataacct 770101 ttactcatat gtatcctccc ttggaataat ttttctcggt aaagagctta aacatattta 770161 aacaccttaa aacaacaaaa gtaaagaaaa aatttccttg taaactattt acttttattc 770221 tatttattgt tattgtttat ttaagttctc tgactattct atcaatattc agggaaccac 770281 atatcttatt aaagggggga aaaccatgag aaaattaaga aaaaactgga gaaaatcgat 770341 tgttagcccg gttctttata ctaatgaaaa atggtaaaca cttagggaat agcatttaat 770401 gctattcctt atttcaacaa acaaatcggg aggttatcgt aatttgactc tattaatgca 770461 agatcataaa tcaatttaca ataaagatat agaaatatta attgaagttg aagaacttat 770521 tacttctgtt ccagaaaata aaaaaaatga ttttaagagt ttaatcgata atagaattat 770581 gactctacta aataaaattc aacaccctgt agcagcggaa aatgtgtttg ggatgtgtat 770641 tgcttatccg aatacttaca taaggtatag attaattgat ttcgttgaaa aatgggtacc 770701 ttatttctct gctgtagaaa ctataatcaa tctaacccag gatccggatg atttagtttc 770761 ttttaaagct atggatgtct gtgcaaatca taaaattgaa gaatctgtag catatttgtc 770821 ttcgattatt gatgatgtcc gggagagtat aagctaccct aaaaaacctg tgggattagg 770881 ggcccaaaaa gtattaagta cattattaga tatattcggt gttgaaaaac atgaagagct 770941 agtaatgcta aaaaattatt ttgatcaaaa tggtatactt cctaataact ttgactttga 771001 agaaaaaatt cctcaaagtc taatagagga attcgaaaaa acagaagaag atgggatgat 771061 tttaattccg ggtggctttt ttgaattcgg tttaaatgaa aatgaaattc ctgacaaaac 771121 atttaattgg aaagatgctg ttcctagaca aaaagtatgg ttacctccat tttttatcga 771181 taagtatcct gttacaaata aagattatga tatctttacc gagttcatag aggaaaatgg 771241 gcatatattc tgtcatccta atgaaccgca gaataaacaa catagaagaa atacatattg 771301 ggatgatagg tatttagata atcatcccgt tacaggtata gatttttatg atgcatttgc 771361 ttacgcaaga tataagggga aagaattgcc aaccgagttt caatgggaaa aagctgctcg 771421 aggcgaaaag ggtaatgtct ggccttgggg agataaattt gatcctgcaa aggttcaata 771481 tgctggaagt ctttataatg aacccattac ttctttaaag tcctggagag aaaatttatt 771541 aaaagctcat gctgataaag aattaaatca tttaacaagt gatatttttg aacaaaatgg 771601 tgaaagtccc tatggagtat gcggtatgat cggcggaaca tgggagtgga ctagaagtga 771661 gcttaaaaca aagagagctt tccaccctat ttttgagaat gtaccattta atagtgttaa 771721 ctcatttgcc gttcttaaag gaggatcatt cttctctcat ccaggcttaa tgttcccttc 771781 ttttagagca aaagatattc ctttctgtcg acacaatgaa atggggatta gatgcgtaaa 771841 gaatattcca gtatataaaa ttagagaatc aattaatggg ccaattacta ataaagcaat 771901 ttattaatca ttctaggtta gagacttgat aaaagtatac taacattgtg tagtaatgtt 771961 cagcttgtag aaaaaacaat gttttttcta caagatttta ttttaaatgc ttttcaaaat 772021 tatcagggat tgagaatcag aaaaagagcc attaagctcg atcttagcta ggtattacga 772081 tcttctgtat attattgtga gaaatataga agattcagtt agttagcatt tcgattttaa 772141 gctgagcctg caatagcaaa gcatctgttt tgattattct ttttctgata cataagctaa 772201 ttttgtcgct tttctttttt gtcttttcac gcatttcgag gatgacttac tataattctt 772261 tcagcttttc tatgtgttaa gattcgaata gatgaaataa ctttaacaag ttggtcaata 772321 agaacagatt taactttatg ttaaaagagt atctcgtata gaacataaga agaatgacga 772381 gttttttaag attatcatca attatgtgag aataaaatat tataagggaa aatgaaggct 772441 gtcacgtttc tcgacagccc tagggaattc ctctcctttt catttcgccc gtaatttcgg 772501 gcacagtccc gtcggcaggc acattggctt ctggtcgatc gggcttctca tgatgcagca 772561 ttccaagccg aagacttcac ggaaaaatgg ctgggtgaac acatcttccg gtgttccggc 772621 gttgtatatt tttccgtcca gcacactgat cagatagtca gcatattgag cggcttggtt 772681 taaatcatgg agcaccatga caacggtgcg gccatggtcg cggttcagct ttttcagcag 772741 ttcaagcact tcaatctgat gtgagatgtc taaatacgtg gtcggctcat caagcaaaag 772801 caaatcagtg ccttgcgcaa gtgccatgga aatccaggct ctttgtcttt ggccgcctga 772861 gagggcatca agtgtccgat ccttcagttc aatcatgccc gttgcttcca gcgcccactc 772921 taccatgtca tgatcctctt gggtatgctt ggataacagc tttttgtgag gatgtctgcc 772981 aaaatagcat aattcctcta ccgtcaatcc ttcaggagcc tgaggagatt gtggaagaat 773041 ggccagtttt tttgcgactt cttttgatgg ctggcggtgg atgtcttttc cttctagtag 773101 cactgtaccg ctttttgggg ccatcagcct ggcgagcgat ttgaggattg ttgatttacc 773161 gcagccatta gcgccgatga gcgcagtgat ttttccttct tctatcttta agtcgactcc 773221 gtcaataatc actgtactgt catatgaaag agtgagctgg tctgcagcca gttttcccat 773281 ggtatcctct ccctactgtt tcctcgcttc gaatttcaat aaatataaga aataaggcgc 773341 gccgatcacg gctgtcagta ttccggcagg tatttcaacc ggaggcatga tgccgcgccc 773401 taacgtatct gcaattaata atataatagc accaatcaat gccgatgcag gcagtaaata 773461 tttagctttt tctccggtaa gccgtctggc gatatgcgga gcaagcaagc cgataaaacc 773521 gattgagccg acgacggcta cacagcttcc cgccagcgcc accgcggtga aaatcaggat 773581 gaatctcagc cggtttgcgt tttctccgag accctgtgca agctcatccc cgagtgacat 773641 aagatccagc ttcggtatga gtatgcagac gatcggaaaa agaatcaaaa gccatggcgc 773701 aagcagcttg acttcttccc agtttcttcc ccagaggctt cctgtcagcc aaatgagtgc 773761 agcattcacg tcgcctggaa acttgaccat catatattgc attccggcgt ggcagaccgc 773821 gcctaaagca atgcctgata aagccagtga agagggctga atgctctttt ttcgggctat 773881 cattaataat agtacagcaa taatggcggc tccggcaaat gcggagaacg gaagcacgta 773941 taccggcgac tcaggaaaga tgagaatcac agccatcgcc gcaagtccgg agccttttga 774001 aatgccgaca acgtccgggg aagcgagcgg atttcggatc acaccctgta aaatcgctcc 774061 ggcagcggca agtccagcac ctgccaaaat cgctaatata atgcggggaa ggcgatattg 774121 ctggatgata aattcaaagg aatgatccag tcccagcaga ttcgtcacta ccgcatcagg 774181 tgaaatgtat aatgcaccga ttccaatgct gatgacggac agaacgatta aaatcacggc 774241 caatatgagt atcgccagta aggggcgttt ttgttttctg gttgttttct tcatttcagg 774301 tttcgccctt tccttgccaa atataagaaa aacggcgttc cgataatcgc ggtgacaatg 774361 ccgaccggtg attcataagg aaatgcaatc catctggcca gaacatctgc gtacaccagc 774421 aaaatggcac cgaacagtgc cgaaaacgga agcacgtatt gataatgttc tccgatcagc 774481 ttgcggacaa tatgcgggac gagcagcccg acaaagccaa tcggcccggc gacggctacg 774541 gaagcgccgg aaagaattaa aataatcaaa ctgatcagaa tcctgatgcc gttcatattt 774601 tgtccaagcc cttttgctgt ttcgtctccg agaccgagaa cagaaacaga accggaaaat 774661 acgagggcaa gcccgatgcc aatgacagaa aaaggagcga tggttatgac gtcctgccag 774721 ttgctgccgt cgattgcgcc tgtcatccag tacagaacat cctcacctga ctcatttaaa 774781 ataatgatgg cctgtgtcat agaggagagg aacaagtgca cggccattcc tgacagcgcc 774841 agcttgacag gcgtcattcc gccggatgag gcaatcatat acacaatcgc gccgcctgct 774901 gccgcacccg caaaagcgaa tataacagat gaatagggcg atgccggcag aatgacgaga 774961 gaagcaacaa caaaaagcga tgcacccgca ttcacaccga aaatttgggg tgaagccaga 775021 ggatttctgg tcatagcctg catcagcgcc cctgctacag ctaggctggc gccgacaaaa 775081 acgccgatta atgtgcgggg aaggcgaaga gtagagatga tgagctgttc ctttgaaccg 775141 tcccatacaa aaagatattt caatgaatct atgatgctga tgtctgaggc tcctactgaa 775201 agattcagcc caagcccaaa tataaaaata atcagtgcaa tgataaacat catcagtctt 775261 gatgatgagc gccgtttggc tgaatgatac aacagtctca cttccttact gcgtctggtt 775321 gcaaaaacga agaagcaagg attcccctcg cttctcattt gtcctattta ttatacactt 775381 ttttaagcac atctttggcg cttgtttcac tagacttgat gcctctgaat cttgtccaag 775441 tgtcacggtc cgcatcatag acttgtccat ttttcaccgc tttgagattt ttccagagcg 775501 ggttcgtttt ccactcatct acaatggttt tgccttcgtt ggctgagatg aacaaaatat 775561 caggatcgat tttgctcaat tgctcaaggc tgacctcttg ataggcgtta tctgacttca 775621 cagcgtgtgt aaagcctagc attttaaaga tttctccgtc ataggatgat gatgtatgaa 775681 gctggaagga atccgctctt gcaacgccga gaacgatgtt gcggttttca tctttcggaa 775741 gttcggcttt tagatcgttg atgacttttt tgtgctcggc aagcttttct tttccttcat 775801 cttctttatt taatgcttta gcaatggtcg taaagctgtc gatcgtttcg tcatatgtcg 775861 cttcacggct ttttaattca atcgtcgggg cgattttttt cagctgttta taaatgtttt 775921 tatggcgctc agcgtcagcg atgattaaat caggcttcaa ggaactgatg acctcaagat 775981 tgggttcgct gcgtgtgcct acagatgtgt aatcaatgga gctgccgaca agctttttaa 776041 tcatatcttt tttgttgtca tctgcgatgc ccaccggcgt aatgccgaga ttgtgaacgg 776101 catccaagaa tgaaagctca agcacaacca cccgcttagg tgtgccgctt actgtcgttt 776161 ttccttcttc gtcatggatc actctggaat ccttagactc gcttttgccg cttccgttgt 776221 tattctggct tgatgaacag ccggatacaa tgaggcaggc gagcaataaa acactcatga 776281 tggcaatcaa cttgttagaa taggtgcgca tgtcattctt ccttttttca gatttagtaa 776341 tgagaatcat tatcacatgt aacactataa tagcatggct tatcatgtca atattttttt 776401 agtaaagaaa gctgcgtttt tactgctttc tcatgaaagc atcatcagac acaaataagt 776461 ggtatgcagc gttaccgtgt cttcgagaca aaaacgcatg ggcgttggct ttagaggttt 776521 cgaacatatc agcagtgaca taaggaagga gagtgctgag ataaccggac aatttctttt 776581 ctatttcatc tgttagtgca aattcaatgt cgccgatatt catgataatc gagaaaacaa 776641 agtcgatatc gatatgaaaa tgttcctcgg caaaaaccgc aagctcgtga attcctggtg 776701 aacatccggc acgcttatgg aaaatctgtt tgactaaatc actcacaatc caagcattgt 776761 attgctgttc tggtgaaaag tattgcatta gacatacctc ctgctcgtac ggataaaggc 776821 agcgtttcat ggtcgtgtgc tccgtgcagc ggcttctcct taattttgat ttttctgaaa 776881 ataggtcccg ttcctatcac tttaccatgg acggaaaaca aatagctact accattcctc 776941 ctgtttttct cttcaatgtt ctggaatctg tttcaggtac agacgatcgg gtatgaaaga 777001 aatatagaaa acatgaagga ggaatatcga catgaaacca gttgtaaaag agtatacaaa 777061 tgacgaacag ctcatgaaag atgtagagga attgcagaaa atgggtgttg cgaaagagga 777121 tgtatacgtc ttagctcacg acgatgacag aacggaacgc ctggctgaca acacgaacgc 777181 caacacgatc ggagccaaag aaacaggttt caagcacgcg gtgggaaata tcttcaataa 777241 aaaaggagac gagctccgca ataaaattca cgaaatcggt ttttctgaag atgaagccgc 777301 tcaatttgaa aaacgcttag atgaaggaaa agtgcttctc tttgtgacag ataacgaaaa 777361 agtgaaagct tgggcataaa gcaaggaaaa aaccaaaagg ccaatgtcgg ccttttggtt 777421 tttttgcggt ctttgcggtg ggattttgca gaatgccgca ataggatagc ggaacatttt 777481 cggttctgaa tgtccctcaa tttgctatta tatttttgtg ataaattgga ataaaatctc 777541 acaaaataga aaatgggggt acatagtgga tgaaaaaagt gatgttagct acggctttgt 777601 ttttaggatt gactccagct ggcgcgaacg cagctgattt aggccaccag acgttgggat 777661 ccaatgatgg ctggggcgcg tactcgaccg gcacgacagg cggatcaaaa gcatcctcct 777721 caaatgtgta taccgtcagc aacagaaacc agcttgtctc ggcattaggg aaggaaacga 777781 acacaacgcc aaaaatcatt tatatcaagg gaacgattga catgaacgtg gatgacaatc 777841 tgaagccgct tggcctaaat gactataaag atccggagta tgatttggac aaatatttga 777901 aagcctatga tcctagcaca tggggcaaaa aagagccgtc gggaacacaa gaagaagcga 777961 gagcacgctc tcagaaaaac caaaaagcac gggtcatggt ggatatccct gcaaacacga 778021 cgatcgtcgg ttcagggact aacgctaaag tcgtgggagg aaacttccaa atcaagagtg 778081 ataacgtcat tattcgcaac attgaattcc aggatgccta tgactatttt ccgcaatggg 778141 atccgactga cggaagctca gggaactgga actcacaata cgacaacatc acgataaacg 778201 gcggcacaca catctggatt gatcactgta catttaatga cggttcgcgt ccggacagca 778261 catcaccgaa atattatgga agaaaatatc agcaccatga cggccaaacg gatgcttcca 778321 acggtgctaa ctatatcacg atgtcctaca actattatca cgatcatgat aaaagctcca 778381 ttttcggatc aagtgacagc aaaacctccg atgacggcaa attaaaaatt acgctgcatc 778441 ataaccgcta taaaaatatt gtccagcgcg cgccgagagt ccgcttcggg caagtgcacg 778501 tatacaacaa ctattatgaa ggaagcacaa gctcttcaag ttatcctttt agctatgcat 778561 ggggaatcgg aaagtcatct aaaatctatg cccaaaacaa tgtcattgac gtaccgggac 778621 tgtcagctgc taaaacgatc agcgtattca gcgggggaac ggctttatat gactccggca 778681 cgttgctgaa cggcacacag atcaacgcat cggctgcaaa cgggctgagc tcttctgtcg 778741 gctggacgcc gtctctgcat ggatcgattg atgcttctgc taatgtgaaa tcaaatgtta 778801 taaatcaagc gggtgcgggt aaattaaatt aagaaagtga aaaacacaaa gggtgctaac 778861 ctttgtgttt tttaattaat taaaatgttt attaacttag ttaaggagta gaatggaaaa 778921 ggggatcgga aaacaagtat ataggaggag acctatttat ggcttcagaa aaagacgcag 778981 gaaaacagtc agcagtaaag cttgttccat tgcttattac tgtcgctgtg ggactaatca 779041 tctggtttat tcccgctccg tccggacttg aacctaaagc ttggcatttg tttgcgattt 779101 ttgtcgcaac aattatcggc tttatctcca agcccttgcc aatgggtgca attgcaattt 779161 ttgcattggc ggttactgca ctaactggaa cactatcaat tgaggataca ttaagcggat 779221 tcgggaataa gaccatttgg cttatcgtta tcgcattctt tatttcccgg ggatttatca 779281 aaaccggtct cggtgcgaga atttcgtatg tattcgttca gaaattcgga aaaaaaaccc 779341 ttggactttc ttattcactg ctattcagtg atttaatact ttcacctgct attccaagta 779401 atacggcgcg tgcaggaggc attatatttc ctattatcag atcattatcc gaaacattcg 779461 gatcaagccc ggcaaatgga acagagagaa aaatcggtgc attcttatta aaaaccggtt 779521 ttcaggggaa tctgatcaca tctgctatgt tcctgacagc gatggcggcg aacccgctga 779581 ttgccaagct ggcccatgat gtcgcagggg tggacttaac atggacaagc tgggcaattg 779641 ccgcgattgt accgggactt gtaagcttaa tcatcacgcc gcttgtgatt tacaaactgt 779701 atccgccgga aatcaaagaa acaccggatg cggcgaaaat cgcaacagaa aaactgaaag 779761 aaatgggacc gttcaaaaaa tcggagcttt ccatggttat cgtgtttctt ttggtgcttg 779821 tgctgtggat ttttggcggc agcttcaaca tcgacgctac cacaaccgca ttgatcggtt 779881 tggccgttct cttattatca caagttctga cttgggatga tatcaagaaa gaacagggcg 779941 cttgggatac gctcacttgg tttgcggcgc ttgtcatgct cgccaacttc ttgaatgaat 780001 taggcatggt gtcttggttc agtaatgcca tgaaatcatc cgtatcaggg ttctcttgga 780061 ttgtggcatt catcatttta attgttgtgt attattactc tcactatttc tttgcaagtg 780121 cgacagccca catcagtgcg atgtattcag catttttggc tgtcgtcgtg gcagcgggcg 780181 caccgccgct tttagcagcg ctgagcctcg cgttcatcag caacctgttc gggtcaacga 780241 ctcactacgg ttctggagcg gctccggtct tcttcggagc aggctacatc ccgcaaggca 780301 aatggtggtc catcggattt atcctgtcga ttgttcatat catcgtatgg cttgtgatcg 780361 gcggattatg gtggaaagta ctaggaatat ggtagaaaga aaaaggcaga cgcggtctgc 780421 ctttttttat tttcactcct tcgtaagaaa atggattttg aaaaatgaga aaattccctg 780481 tgaaaaatgg tatgatctag gtagaaagga cggctggtgc tgtggtgaaa aagcggttcc 780541 atttttccct gcaaacaaaa ataatggggc tgattgcggc tctgctggtc tttgtcattg 780601 gtgtgctgac cattacgtta gccgttcagc atacacaggg agaacggaga caggcagagc 780661 agctggcggt tcaaacggcg agaaccattt cctatatgcc gccggttaaa gagctcattg 780721 agagaaaaga cggacatgcg gctcagacgc aagaggtcat tgaacaaatg aaagaacaga 780781 ctggtgcgtt tgccatttat gttttgaacg aaaaaggaga cattcgcagc gcctctggaa 780841 aaagcggatt aaagaaactg gagcgcagca gagaaatttt gtttggcggt tcgcatgttt 780901 ctgaaacaaa agcggatgga cgaagagtga tcagagggag cgcgccgatt ataaaagaac 780961 agaagggata cagccaagtg atcggcagcg tgtctgttga ttttctgcaa acggagacag 781021 agcaaagcat caaaaagcat ttgagaaatt tgagtgtgat tgctgtgctt gtactgctgc 781081 tcggatttat tggcgccgcc gtgctggcga aaagcatcag aaaggatacg ctcgggcttg 781141 aaccgcatga gatcgcggct ctatatcgtg agaggaacgc aatgcttttc gcgattcgag 781201 aagggattat tgccaccaat cgtgaaggcg tcgtcaccat gatgaacgta tcggcggccg 781261 agatgctgaa gctgcccgag cctgtgatcc atcttcctat agatgacgtc atgccgggag 781321 cagggctgat gtctgtgctt gaaaaaggag aaatgctgcc gaaccaggaa gtaagcgtca 781381 acgatcaagt gtttattatc aatacgaaag tgatgaatca aggcgggcag gcgtatggga 781441 ttgtcgtcag cttcagggag aaaacagagc tgaagaagct gatcgacaca ttgacagagg 781501 ttcgcaaata ttcagaggat ctcagggcgc agactcatga attttcaaat aagctttatg 781561 cgattttagg gctgcttgag cttggggagt atgatgaagc cattgatctg attaaagagg 781621 aatatgcgat acaaaatgaa cagcatgatc ttttattcca taacatccat tcgcagcagg 781681 tgcaggccat tttgttaggg aaaataagca aggcatcgga aaagaaggtc aagctggtga 781741 ttgatgagaa cagctcactc gcgcctcttc ctgcgcatat cggcttgtcc catcttatta 781801 cgattattgg caatttaatt gataacgctt tcgaagctgt agcggagcaa agcgtgaagg 781861 aagttttgtt ttttatcacg gatatgggcc atgacattgt cattgaagta tcagacacag 781921 ggcccggtgt gccgccagag aaaatagaag ctgtgtttga gagaggctat tcttcaaagg 781981 ggatgaggag aggctacggt ctggccaatg tgaaagactc agtgcgtgaa ctgggcggct 782041 ggatcgaact ggcgaatcaa aaaactggcg gggcggtatt cactgtattt ataccgaagg 782101 agaaacaaag ggggaatcca tttgattcac atcgcgattg cggaggatga ttttcgagtt 782161 gcgcaaatcc atgagagatt gattaaacag cttgatggat tcaagattat cggcaaggcg 782221 gctaacgcaa aagagacatt ggcgcttttg aaggaacaca aggctgattt gcttctgctg 782281 gatatttata tgccggacga gcttgggacc gcgttgattc ctgatatacg aagccgattt 782341 cctgaagtgg acattatgat tatcacagcg gcaacagaaa cccgtcattt gcaggaagcg 782401 ctaagggcgg gaattgccca ctatttgatc aaacccgtaa cagctgacaa gttcaggcag 782461 gtgctgcttc agtataaaga aaaaaggaag ctgctcatgt ctcagccgga ggtcagccaa 782521 tccatgatcg accatatttt tgggaacggt gtgaagacag ctttgccggc agaggatttg 782581 ccgactggca ttaattcgat tacactgcga aaaattaagg aagcgcttca gactgcgtca 782641 gaaggattga cagcggagga acttggggaa aaaatggggg cgtcacgaac aactgcccgc 782701 cgttatgccg agtaccttgt gtcaaaggaa gaagcaagag ccgagcttga atacgggatt 782761 atcggcaggc cggagagaaa atattatttg gcggcggatt agatatgaaa aaatctataa 782821 tcctattgaa tattctattg atctttatgc agggtgatat caggcaggcg gctgcgccgc 782881 gcctgccgga cgggccgata gaaattgtcg tccctgccga accttctggc ggctgggatg 782941 tcacagcgca ggcgatccaa tcagttttga ggcagaagca gatcgtgaag gatgatgttc 783001 atatcgtcta taaatccggc ggcgggggag agaaaggctg gaaatatgtc aacaaaagca 783061 gcaaacaaac catcagcatg acgtccagcc taatattgag caatgatctt ctcgggcaaa 783121 gcaaattaaa aatgtccgat tttacgccgc tcgccattct ctccaaggaa tggcagacgg 783181 ttgcattgcc aaaaggatca gcgttaacaa atggcaagga tgtgctgaat gagatcaaca 783241 tgcatcccgg caaggtgaga atcggctttg ccccggggtt tggcaatgat gatcagctct 783301 cgttcgtcag agcggcagat atgtacggca ttgacccgtt tgacattcaa ttctcacagt 783361 atgacagcag cgaacagctc attcaggcgc tgatcagaca tgagatagaa gcggcttcca 783421 tgacactttc tgaagcgaaa ccatatgaac gaaacggcga tatcacgtta gccgctgtaa 783481 cgtctgataa aagacttccc ggttttccaa atgtaccgac gtggaaggag cagggaatcc 783541 cgtttgtttt ttctcattgg agagggattt tgggcccgaa aaatatgtct gaggaagaga 783601 tttcttactg ggatcaagcg ctaaagaagg tcacctcctc acctgaatgg aagcggaaaa 783661 taaacgaaca ggactgggaa agcttttatt taaacagcag ggaaacgaaa cggtttttag 783721 aagagcaatc tgctttttat caaagcatca tgacaggaaa ttaaaatccc gacatcccgg 783781 gatttttttc atgccgaaaa ttgatcaaaa agaacaaaac ggttttaaaa aattaaaaat 783841 acaaaaaaac caaattattt acttgcggtt ggttttccca tacgatggca aaaaggcaag 783901 acaaaaaggg gagtaaggga gaaaaaaatg taagcggatt catttaaggg ggaatggatg 783961 tgttagcaat cttaggcttt ctcatgatgc ttgtgtttat ggcattgatc atgacaaaac 784021 ggctttctgt tttaacagca ttagttttga cgccgattgt gtttgcgctt atcgccggat 784081 ttggatttac tgaagttggg gacatgatga tttcggggat tcagcaagtc gcgccgactg 784141 cggtcatgat tatgtttgcg atcttatatt ttggaattat gattgataca ggcctgtttg 784201 atccaatggt tggcaaaatt ttaagcatgg tcaaaggaga ccctttaaaa attgttgtcg 784261 ggacagcggt tcttacaatg ctcgtcgcct tggacggaga tggctcgaca acgtacatga 784321 ttacgacaag cgccatgctt ccgctctatt tgctgctagg catccggcca attatcttgg 784381 caggaatcgc gggagtcggc atgggaatca tgaacacgat tccatgggga ggtgcgacgc 784441 cgagggcggc gagtgcgctg ggggttgatc cagctgagct tacagggccg atgattcctg 784501 tcattgcaag cgggatgctt tgtatggtgg cagttgcgta tgtgcttgga aaagcggaac 784561 gaaagcgcct tggtgtgatt gaactgaaac agccagccaa tgccaatgaa ccggctgctg 784621 cggttgaaga tgagtggaag cggccgaagc tttggtggtt caatttattg ttaacgcttt 784681 ctttaatagg atgtttagta tcgggtaaag tcagtttaac cgtactgttt gtcattgcgt 784741 tttgtattgc gctgattgtg aattatccca atctcgagca tcagagacag cgcatcgcgg 784801 cgcattccag caacgtgctg gctatcggtt caatgatttt tgctgcgggg gtgttcacgg 784861 ggattttgac aggcacgaaa atggttgatg aaatggcgat ctcgctcgtg tccatgatac 784921 cggaacaaat gggcggattg atcccggcga ttgttgcctt aacaagcggc attttcacat 784981 ttttgatgcc gaatgacgcg tatttctacg gggtgctgcc gattttatca gaaacagctg 785041 tcgcatacgg tgtggataaa gtggaaattg ccagagcctc tattatcggc cagccgattc 785101 atatgctgag tccgcttgtg ccatccactc atttgcttgt cggactcgtc ggagtttcta 785161 ttgatgacca tcaaaaattc gcattgaaat gggcggttct cgcagtgatc gtcatgacgg 785221 ctatcgctct attgatcggt gcgatctcta tttccgtatg ataattcagg cgtaatgaca 785281 cacactaacg gcatacaaca ttccggaggt gtcattatga gtgatcctta tatgccgctg 785341 acttcagtca gaagcggagc ggggttcgaa gcggcaaaag gggtgcacgg cctgactgtg 785401 caaattgcga atgtctattt tattcagctg ccttctgaac ctcactcatt tgttttaatt 785461 gatgccggca tgccccaatc agccggcgtg attgtcaatg aagccaaaca aagattcggt 785521 gaagggtttc agctgaaggc gattatcctc acacacgggc actttgacca tattggggca 785581 atcgaagaga tccttgagca ttgggatgtg cctgtttata tccattctcg ggaaatgcct 785641 tatgtaacag gtaaagagga ttatcctccg gctcgtcctg acagcaagag cgggctggtc 785701 gctaagctgt cgccgctgtt tccgcggcac tctatcgata tttcctcaca tgtccaggca 785761 ctgccggaag acggttcagt tccttttctt gacgagtgga tgtggatcgc gacaccagga 785821 cacacgccgg gccatatttc gttattccgc gatgacggcc gcgtgcttgt ggcaggtgat 785881 gctgttatta cagtggaaca ggagaaaatg gctgacgtct tgatacaaaa acaggagctt 785941 cacgggccgc cggcttattt cacgcctgac acagagacgg ccgctgagtc cattctaaag 786001 ctggccggtc ttgaaccgga agcgttattg accgggcacg gcataccgat gaccggcaaa 786061 aactttcgaa gtgacttaac tgaattggca aatcggttat cgtctatttg acacccgcac 786121 cacgcgggtg ttttttattg ttttccagga agttgcagaa aaatcatttg tcttgccgct 786181 taaaaacgat acaatgaaaa gcatgaagtg atgtgaaggg gagagtttgt tggaagaaaa 786241 agaaatactc tggaacgaag cgaaagcgtt tattgccgca tgctatcagg aattgggaaa 786301 ggaggaggaa gtgaaagacc gtctcgcgga cattaaaagt gaaattgacc tgaccggaag 786361 ctatgtacat acgaaggaag agctggagca cggagcgaaa atggcttgga gaaacagcaa 786421 ccgctgcatc ggcagattgt tctggaattc gctgaatgtt atcgacagac gagacgtccg 786481 gacgaaggag gaagtgcgtg atgccctctt tcaccatatt gaaaccgcca ccaataacgg 786541 gaaaatcaga ccgaccatta cgattttccc tccggaagag aagggtgaaa agcaagtcga 786601 gatctggaat catcagctga tccggtacgc tggatatgag tcagacggag aaagaatcgg 786661 cgacccggct tcctgttccc tgacagcagc ctgcgaagag ctcggctggc gcggagagcg 786721 aacggatttt gacctgctgc cgctcatttt tcgcatgaaa ggggacgagc agcctgtctg 786781 gtatgagctg ccgcgttcac ttgtgattga ggttccaatc acacatccgg acatcgaggc 786841 gttttctgat ttggagctga agtggtacgg cgtgcctatt atttctgata tgaagcttga 786901 ggtcgggggc attcattata atgccgcgcc atttaacggc tggtatatgg gcacggagat 786961 cggagcgaga aacctcgcag atgaaaagcg gtacgacaag ctcaaaaaag tagcgtccgt 787021 gatcggcatc gccgctgatt acaatacgga tttatggaag gatcaagcgc tagttgaatt 787081 gaataaagct gtgctgcact cgtataaaaa gcagggtgtc agcatcgttg accatcatac 787141 agcggcaagc cagtttaaac ggtttgaaga acaggaggaa gaagcgggca gaaagctgac 787201 gggggactgg acgtggctga ttccgccaat ttcacccgct gccactcata tcttccaccg 787261 ctcctatgat aactcaatcg ttaagccgaa ctatttttat caagataagc cttatgagta 787321 aacaatagaa aatcgatgat ggccttcaag gctgcgggat tcagtcacag agatgtcggt 787381 aacctttgag aaagggcttc cgttctttac agcctcaaca aacgattgca gggcgttttc 787441 cggaccctct gccaaaatct cgacacgccc gtcatcacgg tttttgaccc agccggccag 787501 ttttcgctta tcagcttcca tttgaacaaa atagcgaaag cccacacctt gaacccggcc 787561 gtctacaatg attcggtatt gaagcatgta aaaaccacct tttcttttta tgataatcaa 787621 tcattttaca acctgtaaag gggatgtgtt tgtatgaaac aagagcgcta ttcagttctt 787681 tctcttaatc tgggaaaacc gcagacgctt gaatatgacg gaaagaaaat cgaaaccggc 787741 atcatgaagc ggccggctaa atcagccgtc atgctgtatc gggagaattt tgaaggagac 787801 ggacaggcgg acctcgtcaa ccacggcgga cctgataagg ctgtctgtgt ctacccggcg 787861 gagcattatc cgttttggga agagttcctc tcaagaccgc tgtcaaatgc cgcatttgga 787921 gaaaatctga cggtcgcggg cctgactgag gagaatgttt gcatcgggga tgtgttcaga 787981 cttgatgaag ctgttgttca ggtcagccag ccgcgccagc cgtgtgtaaa gctggcgaaa 788041 aagtttggtg taaaagaaat ggtgctgaag gtccagcaaa ccggctatac agggttttat 788101 tttcgcgtgc tggaggaggg cagggtgtct cccggcgcga accttgaatt gctgtccaga 788161 ggagagaaag gcatatccgt ccagttcgcg aaccgcatca actaccatga tgcaaaaaat 788221 ctcaccgcca ttgaacggat tttaagtgag gctgcactat cggaaagctg gagagcgtcc 788281 tttatgaaaa aaaaggacag gctgctgccg gttgaataga aaaaagccgc gcatatcaac 788341 gtgcgcggct ttgccatatt taagattgtt ttttctttga ttcaagcagg ttggcaagaa 788401 aataggtttt atagctttga agctttcttc cttcatggtg cgtgatcccc tgctttttta 788461 gttctgccac ataccagcct ttactgccgt aatgcatgtc agaaaactcc tttccctatc 788521 tgatttcgaa acgattggca ttgtaacatc tataaaaaga tgctgaaaag agatgcgggg 788581 aaaactgagc ctttcgcact agatgtacga atgttcttct gaatgtatat gcggagcaaa 788641 agccgaatat gatttaatgg ccggttagtt tgatcatgac aacgccaaat gtcataatgg 788701 cgaaaacaat gccgatatat gtgagcatcc cgtttttttt cttaacgccg taaacggtca 788761 taatgatgcc ttcaatgaaa aaaatgatgc cgaaaataat aaaccacatg cagataaagg 788821 ctcctttcac agacataata gtagtgtagc atatctgaaa gagccgggct gtgacaatat 788881 caagaaagcc gggcgcatat cgcccggctc atgttttatt gtttatcaac caatttgacc 788941 agaagctgtg ccaaatgttc tttctcatct tcgtctgcaa cgctccaaag ctcttgcagc 789001 agcatttctt caccgttttg cggctcttca tgctttgcga ggtagtctcc caggatcgca 789061 gcgcttttta caagcttgcc gtcatccaat cccagctttt tgcctcggtt gacttgtttt 789121 ttcaggtagc ctttaaattc ctcaaagtct tttaaaatgt cttcttttat tgtgccatgc 789181 atcgcgttca tttcgttttc aatttggatt ttttcttgat ctctgttcat tgcaagacct 789241 cctcgtacag aataatgatg ctttacctgc aattggagga ggttaaacct gccggaagcc 789301 cggaatgtgt tttacagttt cgtcaggata atcggttcat cttttgtgat gacgatcgtg 789361 tgttcaactt gggcaaccat gcttttatcc ggcgtcttga acgtccagcc gtctccagct 789421 tcaacaatcg tttctgcttt cgttgaaata aacggttcaa gcgcgatgac tgtgccattt 789481 ttgaacagcg cattatcaaa cggatcataa tagttcatga tgtggttcgg cgcttcatgc 789541 aggcttcggc cgattccgtg gccggtcagg gttttgatga cggtaaagcc ttgagagcgt 789601 gcttcatgat aaacggctct tccgatctgg ttttggcgct tgcccgcttt tgcctgctga 789661 agcccctttt gaaaagcgtt ttccgcgcat tggcaaagct tatgaaggcg ttcttctcct 789721 tcaccgagca caaatgagat gcctgtgtcg gaatagaagc cgccaaattc agcggagatg 789781 tcgatgttga caaggtcccc tgcttttaaa attttggatg tgcttggtat gccgtgagcc 789841 acttcatcat ttacgctgat acatgtcaca cctggaaaat cgtattcctt ctcaggagct 789901 gaaacggcgc cgtgctcatc aagcacagct tttccgataa ggtcaaggtc ttttgtgctc 789961 atgccgggct ctgccttccg cttcatttct tcacgcgcaa gcgcgacgat tcttccgatt 790021 tttttcaggc cttctaattc ttgatcgttt gttacaatca tctgtcattc ccgctttctt 790081 tttaaataat ctagattaag cttaccacaa ctgtcttaaa aataggaaac acacggacct 790141 gggaaaaaag aaataccccc gggaaaattg gtatagatca ctagatatct tatatggtat 790201 atttgaaaaa aaagggtatg agggggatgg gtatgctttc atttttacaa aaactcggga 790261 agtcatttat gctcccgatt gcggttctgc ctgcggttgg aattatcctt gcgcttggca 790321 gagaggatgt atttaatatc ccgtttgtct atcaggcggg gacggcggtt tttgatcatc 790381 tgccgcttat ttttgcgatc ggtattgcca tcggcatttc aaaagacagc aatggggcag 790441 cgggtttatc aggggcgata tcgtatctga tgcttgacgc ggcaacaaag acaattgata 790501 aaacaaataa catggcggtg tttgggggaa ttattgccgg tttaattgcc ggttacacct 790561 ataaccgctt caaggatacc aagctgcctg aatatctcgg gttcttcagt ggcagacggc 790621 ttgtgccgat tttaacagcc attattacga tcattttagc gggcatattc ggagtggtct 790681 ggccgccgat tcaatcgtgt atcaactcgt ttggagagtg gatgctcggg ctcggcggca 790741 tcggggcagg catattcggc ctattcaaca ggctgttaat tccgcttggc cttcaccatg 790801 tgctgaacaa tattttctgg ttccaattcg gagaatataa cggagtgaca ggggatttgg 790861 cgcgcttttt cgcgaaagat ccgactgcgg gcacatatat gaccggattt ttcccaatca 790921 tgatgttcgg tcttccggcg gcgtgtctgg ctatggttgt gactgcgaag ccgtctaaac 790981 ggaaagcgac ggctggaatg atgattggat ttgctttaac ggcgtttatc acagggatta 791041 cggagccgat tgagtttgca tttatgtttt tatctccgct tttatacgct gttcacgcgg 791101 tcttaaccgg gttatcttta tttatcgtca actggctcgg catccgctca ggcttctctt 791161 tttcagccgg agctatcgat tatgtgctca gctatggaat cgcggaaaaa ccgctgcttc 791221 tgcttttggt aggtatatgc tatgcggcag tatactttat cgtgttttat gtactgatta 791281 aggctttgaa tttaaaaacg cctggacggg aagacgatga tgtggatgaa gtgctggatg 791341 aaaatactgt tcaggatgta aatgaaaaca tcatgctgaa agggctcggc ggaaaagaaa 791401 accttcaaac cattgatcat tgcgccacaa ggctgcgact gactgtgaag gataccgctt 791461 tggtggatga agcactgcta aagaaagcag gcgcaaaagg ggttgtcaaa tcgggcgggc 791521 aatcggttca agtcattatt ggcccgaatg tggaatttgc agctgaggaa ttgagggctg 791581 ctgtcaaata aaaaagcgga gagggcaacc tctccgcttt ttcttattta tcttcgttat 791641 cctttgacgt ttcggaagaa tcttcgtcat gttttgtgta atcataatca gaaggattca 791701 ccttcttaaa acctttcggc tcgtagaacc gcagcaggtc tccgtttatg attttatcgg 791761 acatttcaag ttccttcttg acgagtgagt cttctgactt gtcgacttcg gattcatcga 791821 gttcttttcc ggttttcgtg tcgtaatact taccggatat tttcgtgtac ttcggtgaaa 791881 taaagtctcc gtttcggaac ggaatcactt cacggtgttc tttcgataaa atatcagaac 791941 cggacatcag atagtccttc gtatccactc cgagcagatg cagaatggta ggagccacat 792001 caacgtctcc ggcatattta tgaactttct cgcccttcac gccggcagcg tggataaaga 792061 gcggcacccg ttgaagctgg gcgttgtcgt aatcagtgat ttcatccttg ccaagcactt 792121 tcgccatcgc tttattgtgg ttttcagaga tgccgtagtg gtctccgtac atcacaataa 792181 tcgatttatc atataacccg tcttttttca gatcattgaa gaattgttca atggactgat 792241 caaggtaatg ggctgactgg aaatagttat cgacgacaga gtcaccaaag tctccagccg 792301 ggaagtctgt atccccctca tccattccga atgggaagtg gttggaaagg gtaatgaact 792361 tcgtatagaa cggctgcggc aggctttcca gcagcggcat tgattctttg aagaacggtt 792421 tgtctttcat gccgtagttt ttcgtgtttt cttcgttcat gtcatagtaa gcagaatcaa 792481 agaatttatc aatgccttcc gccttgtaca tttcgttacg gttccagaac gtctgcgtgt 792541 tcccgtggaa agtagcagat gtgtaattct tagacttcag aatcgccgga acggattgca 792601 gcgtgttttg cgctttgttt acgaaaactg aaccttgagc cagcgggtac agagagtttt 792661 ccatcataaa ttcagcatca gatgttttac cttgtcccgt ttggtggaaa aagttatcaa 792721 agtagaacgt ttcgttatca tgtgccagtt tatttaagaa tggtgtcact tctttgccgt 792781 caattttata gtcgatgata aatgactgca aagattcaag tgaaacgtaa atgacgtttt 792841 ttccttccgc tttgccgaaa tacacgttat tcggcacatc gtaattggct ttcatgtagt 792901 tttctacttc cgttacgtcg ctggaatcgg caagcgcgcg ctggctgttg gacttgatat 792961 tctgtacagc gtcataaatc gtgaaattgt atgttcccaa gtatttcaca agatagttcc 793021 ggtcgaatga tcttgtcagc aattcaggac ggtctgattc cgcaactgcc aggttgatca 793081 agaacacaag aattgaagac gcaaaaataa ttcggaacga ttttttgctt gacgtttcgg 793141 caggcttgtt tactttgatc gccaagatga tcaggatgat cgtatcgata aagtaaaagg 793201 cgtcagtcgg tctcatcagc gaaaatgcgc tgtcaccgag ttggccgccg tttgttttag 793261 cctgcataat gaccggaatt gtaataaaat cattgaaaaa tctgtagtac acaatgttgg 793321 cgtacagtaa aaaagacatt aaaaaatgaa tcactataat ggctgtctgc tgtaattttt 793381 tcttgaacaa gagtccaaag ccaagaaaga acaagcttga gctaagagga ttcacaaaaa 793441 gcaatatttt ttgtatcgtg ttgtctattc ctaagttgaa attcaggaca taaccgacat 793501 acgttttgat ccataacagg acgaccgcaa ttaagaagaa ggccagtcct ctttctttta 793561 taaatgtttt cattgttaca ctcctttttt ccgatccagt tcgagcgaaa cgatagaaaa 793621 aacgaacgta tccaatataa cacgaatcag cagattagaa aagtgaaaat cgtatgaggg 793681 agaaagtggc gaaaaacgcc gtcgaatcaa cgtttcgctt tgatattacc aaatgtaaaa 793741 caaggtatct ttctagaaat aaaggaataa aatggtacat tgagaattgt atgataaaat 793801 ataaggtata gataaaaaga ggtgaaatga tggatttttc ccatattgtg tctgaagata 793861 aaattaagcg cgccatcaaa gacggggact ttcaaaacct cccgggaatg gggaagccgc 793921 tgccgaagga tgacgcggca cacttgccgg aatcgctgcg catgggctat cgtattttga 793981 aaaacgcggg aatggcagag gacgagggcg cgctcaaaaa agagcttatg accatcgacc 794041 atttaatcga aaagtgctat gacgaaaaag aacgcgagca attaatcaga aaaaaatctg 794101 aaaagcaatt gctgcttgat aagcttgtcg acaaaaaagg catgttttca aagccagcat 794161 ccgcttttta taagaataaa gtatatgacc ggcttggacg aaacagacct tcttccagct 794221 gatttgtctt gtctgcagga tggcgattga taaaagccat cctttttatg ttccaagttc 794281 tatgtcaaaa ggtttatgtt tttccatcta tgggaaatga ttcataaacg aaaaaagggt 794341 gatgggatgg aacgactatt agtatggata gagcatatat ctgattggct gtggggtccg 794401 ccgctaatca tcctgctgac ggggacgggc ttgtatttca ctattttgct gaaaggtttt 794461 caatttcgct atcctttata cattttcaaa cagacaatcg gcagtgtagg aaaaaagccg 794521 aagggagaag gcacagtcac accgcttcag gcattgacct cagccctcag ttcaacgatc 794581 ggtgcagcga acattgtcgg tgtgcccgcc gctattatgt ttgggggacc aggagcggtt 794641 ttttggatgt ggcttattgc cttatttgcc atggcgatta agttttctga aagtgttctt 794701 gctgttcatt acagagaaaa aaatgagcag ggtgaatacg tcgggggacc gatgtattac 794761 ataacaaaag ggctgcgcat gaaatggctc ggcgtattct tctctgttgc gctgattgtg 794821 gagctgattc ccagcattat ggttcaggga aattcggttt cagtctcgct tgccgagacg 794881 ttttctttca ataaaatata cgcaggaatc ggaattgcat ttttgattgg gttagtggtg 794941 ataggagggg taaagcggat cggaaaagta acagagtttg tcgtgcctct tatggcaggg 795001 gcatacgcag gtgccggtct cctgattgtt ctcatgaatc tatcatcagt gccggcgttt 795061 ttctctctcg ttttttcaaa tgcgtttacc tcttcttcag cagttggagg gttcgcaggt 795121 gctgcgttgg cggaaaccgt tcgctgggga tttgcccgcg ggctgtattc taatgaagcc 795181 gggatgggaa cagccccgat tgcacatgcg gcagcaatga ctgatcatcc tgtgcggcaa 795241 gggttttggt ctgtgatcgg cattgtcatt gacaccttaa tcatctgtac gactaccgct 795301 tttatcgtcc ttgcatccgg tgtatggaca gggaagaacg cctcaaatga cccggcagca 795361 ctgacaacgg ccgcatttca gcactatttc ggttctggag gaggatactt cgtttcggtt 795421 tccctggtct tctttgtcgt atcaaccatt atggttgtca ttttttacgg cgtaaagcaa 795481 gctgaatttc tgttcgggcg gctggcagga catgtgatta aattcgttta tttagcggct 795541 attatcatag gtgccgcagg cggagcaaaa gccatttggg gcgtattgga cttagcattg 795601 gtttttattg ttgtcccgaa tgtgattgcg ctcttgttat tgagcagaaa ggtaaaagcg 795661 ctgtacaccg aattctttac atctgaacag tactacctga aagatataag aaaaacgaaa 795721 caaaagcctg tttatccaac aaaagaagct aaaaattcct agtgttttgc ttttgcgccg 795781 aacaatgctt tgctttttat gatcaaataa atgagtaaag gcagcaaaag agaaatcact 795841 acattaatga ttggtttgat tctgttaaag tcgattagct gatttgtatt taaaaaaaac 795901 caaaagccgc atacgactga gaacatgccg gttggtgtat acatggcttt cgggtcgatt 795961 tttgagtgta aaaacgaaag gccgtatacc acgatatata gggaacctgc tatcttcacc 796021 ataatgaccg gaatccaaaa agccgcgatg atcaggtctg agcgatccag aaaatccgta 796081 atgcggatct gcctgatgac catataagca ggatcaaaga aagtagatgt caggttggga 796141 ccaaagacag aaattgaaga aaataacatc acggccagca ataaagcgcc cagcagtatc 796201 gcgaaaatgg tgtattttag cgggacgctc cggtttgaga agagaagcgg aaggataatc 796261 aattccccca ttgtcccaaa cgcgtaatag cctgattgaa ggtatgggat tagaccttca 796321 aaaacaggtg tcaagttttg aagctcaatt tgtgtggcca gcgtaaatgg aaggaacaag 796381 accaggatgc cgaatggaaa taggaatatc tgcgccattc tggtcaatgt ttcttttccc 796441 tctctggcaa tacagatcgc cacaaagata ataacaccgc caagaacagc cattggtgtt 796501 ctcgggagaa ataaaatgtt aatcaaattg atgaaaaaac gtatatcatg agcattgatt 796561 aacaggaaat acaaagaaaa cagtaaaatg ataatccggc ctgcgattgg tgaggaatcg 796621 ctcagcagct catagatatt tttatcctga tgctttttca tcagcctatg catgagccag 796681 agtgccggaa tcacgatgac aacgccgagg atgtagctgt gccaggcatt ttgttttgct 796741 gattcgatca tgagaatcgg agcatgcttt aatccgactg ctaacgtata cagagctccg 796801 aaaaataatc cttggtatgc agaggtcttg tccataaagc acatcctttc tgtcatgttc 796861 aaaacggaat atatttaaac aggtgcccca gccgcggaag caggggattc actctcatat 796921 aaatccatag aaaagcactt cctgcaatta gcaggctgaa ggcccatttt gttagattgt 796981 tagcggaacg aaaattcttc cattcatatg cgtatatggc aatgcacaca atcaatgtct 797041 gtacgatata gctgatcatg ctgacgcacc tccattaatg gctgatcgtt ttgtatagga 797101 caccgccctg ctcaatcgtc acaattggga cgacgtgaac ctccatatcc ttatatacct 797161 cttcccattc ctttttcagc agattcttcg tggttgccgt gcttctgatg gtcctgtctt 797221 gaaagccggc cgggtccgcc tttagctttt gcaaacgatg aacggtgctg atcacgtcct 797281 tctttatggt tctgtttaat gctttttgaa tgatgtaata ctggtcattt tctctcgtct 797341 cataggttga ttggttttcc ataataattc ctttggctct gatctcgatt gtcattgaca 797401 gctttccgtt tttttcagcg gcatgaaagg atgcattgga cttttgaagc tgaatggatg 797461 cttgccccat ttgattcggc aggtctacta tgaattctgg ctggcgggct tgattcagca 797521 acatcagggc tgctgtcatg tgttcatctt tgaaaatatc catcaatctg tcctttttaa 797581 agatcgcaag cccgtcaatt ttcaaattag atttgccttt ccctccaggt tttgttttag 797641 atgcagagat gaccggtgca tacggatcac tgcctatttc tactagatca gacatgaatc 797701 tgcttaagaa aacggggcgg ctcgttgcga taatggccag ctcccgaatc atttccgccg 797761 gaaactgttc aagctgaaca tcggtattta aaatgtcccg cgcttctccc cggctgacta 797821 aaatgagcgc cgttaatctg ttctgcggat ttcgcgttaa aatatcaaag actggggcaa 797881 cgccgtctct cgccatatcc tctccaataa tgactgtacg tctgtgggac gtattgattg 797941 tccgtgacaa ggaggtttgc agcttgttgt tcgcttctct gatcgtagtg ccggaagctg 798001 aatcaacata ccatgttttt gaaccggcag ttccgccgcc gccccctgtt tgtccgccta 798061 attggccgac caagggaatc tgcatggcca ctcgatactg atcttttttc ttatcaatgg 798121 ctgagctgac aacaaatgca atgtcattga tttctgtccg gtcccagcac cccgttagaa 798181 ggatacaaat gagaagcggc aaaacacact tatatattgt tttcttcatc ttttgggtcc 798241 tctcttttcg ctcccttctg tccgttgccg cgcgaatacg tgcccggcct tctggtcatc 798301 gtccaccaag gcgccctgac aaaaatatct tttacttcat ctcgtttaaa cggagaaatc 798361 ccggataaat aaggaatgcc gaaagattgc agcttgcata aatgaagcac taagataatc 798421 gtgccgagca taatgccgaa tatcccaaaa atactcgcca aaaacataag cgggaaacga 798481 agcatcctga tggagatagc taagttaaac cgcggaattg taaatgacgc gatccctgtt 798541 aacgatacga tgatcaccat gggggcagac acaattcccg cttcaacagc ggctgtccca 798601 atgactaggg ccccgagaat actgacggtc tggccgatgg ttttcggcag gcgcactccc 798661 gcctcacgga gagcctcaaa agaaatttcc ataatcaatg cttctatgat ggcggggaaa 798721 ggaatcggtt cacgcgcaga ggccacactg aacattaagt ttgtcggcat taagtcctgg 798781 tggtatgtaa taacggcaac ataaatagcc ggcaaatata aagcaacgaa taaaaacata 798841 tagcgaagcc agcggattaa gttagacatc aaataacgct catagtaatc ttcactggcc 798901 tgcataagct gccaaaacgt aatcgggcct gttaagacaa agggcgtatt atctgtgaaa 798961 atggcaaatc ggccttcgag aagctgggcg gcgacggtgt ccggcctttc tgtgtattgc 799021 agctggggga atggcgagta cgtgtcgtct tcgataaatt cttcaatata tccgctttct 799081 aagacagcat caatctttat ctttttgatt cttttttttg ctttgtcaat aacctttgga 799141 tcggcaagcc cgtcaatata ggccaagaca acatcggttt tggttttcgt gccgatttta 799201 aaagagatca ttttaagctg aaacgttttg acgcgaaagc gcacaagagc ggtattgacc 799261 ctgaggcttt cagtgaagcc ctctcttgac cctctgatgg tcgattctgt tatcggctct 799321 tcaatgcttc ttctttgtcc gccttttata tttaagatca ggccttttga gtgcccgtcg 799381 gcaaataaaa ccgcgttccc ctcaatgatg gatgcagcca ctttgctcat actcgtttct 799441 aatgcaacac ttgaaattga tagagtattt tgcagcgcct cttcatgttc atctatttga 799501 tccgtcaaat gcattaagaa agggcggagg gcgtgatcct gaatatgttc agattttaca 799561 attccttcga tataaacaat aaatccgcac agcccgtttc caaagtcaaa ttgtctaaat 799621 acgatgtctg agcagccttc tgttaataag gtcagatttt cgaggttttc cttcaaattg 799681 ggagagatcg gtctgtcctg attgtcttca agctctttga tgagctgaag cgctttgtcg 799741 cgtttattca tagaggctca ccctgctttt taatgtcata ttcaataagt gcttgtgact 799801 tttagggtaa ccttgtctgt ttcatatatt ccagactagg atgaaagcgc tataaaaaag 799861 tgttgactac ctgtatatac aggaatacaa tatgattata agttgtatat acaagttata 799921 aaaacggata cggaggggtt ggcatggggg aactgaacaa atcggcacgt cagattgtcg 799981 aagcagtcgg cggtgctgaa aatattgcag cggcaactca ttgtgttaca cgtttgcgtt 800041 ttgctttaat agatgaaagc aaggttgacc aagagatgct tgatcaaatt gatgtggtaa 800101 agggatcatt ctcgacaaac ggacagtttc aggtcgtaat cggccaggga actgtcaata 800161 aagtatatgc tgaactggtt aaggaaacgg ggattggcga gtcaacaaag gatgaagtga 800221 agaaggcctc agaaaaaaat atgaatcctt tgcagcgtgc tgtgaaaacg cttgcagata 800281 tttttattcc aatattgcct gcgattgtca cggcgggtct tttaatgggg atcaataaca 800341 ttttaacggc ggaaggcatt ttcttcagca caaaatcgat tgtgcaggtt tatccgcagt 800401 gggcggatct tgctaatatg attaacctga ttgcaggcac ggcctttacg tttttgcctg 800461 cgttaatcgg atggtctgcc gtcaagcggt tcggcggcaa tccgcttctc ggcattgtgc 800521 tcggggttat gctcgtgcat cctgatttgc tgaatgcgtg gggatatggc gcggcagaac 800581 aaagcggaga gatcccggta tggaatctat tcggcctaga ggtgcagaaa gtcggctatc 800641 agggccaggt gctcccaatt ttgcttgctt cttatatgct ggcgaagatt gaggtatttt 800701 taacaaaacg cacacctgag ggcatacagc tgctcgttgt cgcaccaatt acgcttctct 800761 taacaggatt tgcctctttt atcattatcg gcccgattac atttgcgatc ggtaatgtac 800821 tgacttcagg gcttatctcg gtgtttggtt cttttgccgc actgggcggt ctgttatatg 800881 gcggtttcta ctcagcgctc gtgattaccg gtatgcatca cacgtttctt gcagtcgacc 800941 tgcagctcat cggttcaaag ctcggcggca cctttttatg gccgatgctg gcgctttcta 801001 atatcgcaca aggttcggcg gctctggcca tgatgtttat cgtgaaggat gagaaacaaa 801061 aaggcctctc cctcacatca gggatttctg cttatcttgg cattacagag cctgccatct 801121 ttggggtgaa tctgcgatac agattcccgt ttatcattgc aatggtcagc tctggcctgg 801181 ccggaatgta tatttcttct caaggtgtgc tggcaagctc cgtcggtgtc ggcggcgtgc 801241 cggggatttt ctcaatcatg agccagtact ggggcgcgtt tgcaatcggg atggctattg 801301 tattgatcgt gccgtttgcc ggaacatacg cgtatgcgag attcaaacat aaataacaag 801361 tggggagcgg gacgtgttga acgttccctt ttcccgtttt caatttaaat atggtggtgg 801421 aaacagatga aaacagaaca aacgccatgg tggaaaaaag ctgtggttta tcaaatttat 801481 ccgaaaagct ttaacgatac gacaggaaat ggtgttggcg atctgaacgg cattattgaa 801541 aagctggatt acttaaaaac gctacaggtg gatgtgcttt ggctgacgcc gatttatgat 801601 tctccccagc atgataatgg gtacgatatt cgtgattatt actcgattta tcctgaatac 801661 ggaacgatgg aggattttga gcggctagtg tccgaagcac ataaaagaga cctgaaagtc 801721 gtcatggatc ttgttgtcaa tcatacgtca acagagcaca aatggtttcg cgaggcgatc 801781 tcttcaatag acagcccgta ccgtgatttt tatatatgga aaaaaccgca ggaaaacggt 801841 tctgttccga cgaactggga atcgaaattc ggcggctcgg catgggagct tgacgaagca 801901 tcgggccaat actatttgca tctgtttgat gtgacgcagg ctgatttgaa ttgggaaaat 801961 gaagaggtca gaaagcatgt ctatgacatg atgcattttt ggtttgaaaa gggaatagac 802021 ggctttaggc ttgatgtcat caacctgatt tctaaagatc agcgctttcc gaatgcggag 802081 gaaggcgacg gccgctcttt ttacactgac gggccgcggg tgcacgaatt tctgcatgaa 802141 atgaacgaaa aggtgttttc acattacgac agcatgacgg tcggtgagat gtcttcaaca 802201 accgtagacc actgcatccg gtatacgaat cctgacaata aagaacttga tatgacattc 802261 agcttccatc atctcaaggt tgactatcct aacggcgaaa aatgggcctt ggcgccgttt 802321 gattttttga agctgaagga gatcctatct gactggcaaa cggggatgca cgcaggaggg 802381 ggatggaacg ctctgttctg gtgcaatcat gatcagccgc gcgtcgtatc aagatatgga 802441 gatgatggcg catatagggt gaaatcggcg aaaatgcttg ctacggccat tcatatgatg 802501 cagggcacgc cttatattta tcagggcgag gagctgggga tgacgaatcc gaagttcact 802561 gacataagct cctatcggga tgtcgaatcg ctgaacatgt atcacgcctt taaggaaaaa 802621 ggaatggctg atcaagatat tacagccatt ttacaggcga aatcccgtga caattccaga 802681 acccccgttc agtgggatgc tacggaaaat ggtggtttta caacgggcac accatggata 802741 ccggttgcag gaaattaccg ggaaatcaat gctgaagcgg cgctgaggga tcagaattcg 802801 gtgttttacc attatcaaaa attgattcag attcgcaaaa tgtatgacat tgtgacagag 802861 ggtacgtatg agataattgc aaaggatgac ccgaacattt ttgcgtatct cagacacggc 802921 agcaatgaaa agctgctcgt gatcaataat ttttacggga cagaggcggc ctttacactg 802981 ccggactctt tagcgcctga cgaatggaag gcagaggtgc tgttgacgaa cgatgaagca 803041 agggaagggc ttcagaacat gacgcttcgc ccatatgagt ccattgttta tcgtttaacg 803101 aaaccgtgtt aaactaagct gggtggtcca taatgaaggt gaataaattc atcacaattt 803161 ataaagacat cgcacagcaa attgaaggcg gccgatggaa agcggaggag attcttccgt 803221 ctgaacatga gttgaccgca cagtacggta catcaagaga aacggtccga aaggcgcttc 803281 atatgctcgc gcaaaacggt tatatccaga aaatcagggg aaaaggctcc gtcgtgctca 803341 atcgtgaaaa aatgcagttt cccgtttcgg gccttgtcag cttcaaggag ctcgcgcaaa 803401 cgcttggcaa agaaacgaaa acaactgtac acaaattcgg gctggagcct ccgtcagagc 803461 tgatccaaaa acagctccgg gccaatctgg atgacgacat ctgggaagtc atcaggtcta 803521 gaaagattga cggggaacat gtgattttgg acaaggatta ctttttcaga aagcatgtcc 803581 ctcacctgac gaaagaaatt tgtgaaaact ccatatatga atatatagaa ggagagctcg 803641 gtctttcgat cagttacgcc caaaaagaaa ttgtagccga gccgtgtacg gacgaggaca 803701 gagagctgct cgatttacgc ggctatgacc atatggtcgt ggtgagaaac tacgtctttt 803761 tggaggatac cagtttgttt caatatacgg aaagcagaca ccgtctcgac aaattccgat 803821 ttgttgattt tgcgcggcgg gggaaatgag agaggcgcct gcctgcggca gcgcgctttt 803881 ttgtttggta tcaaaattga tactatccaa caaaaatgtg cgtactttta ctttttatca 803941 taatggctac aatagagatg agagtaatct aaaggagagg tgttttacat ggcagatcta 804001 aagacacaaa ttctggatgc atacaatttc aggcatgcga ctaaggaatt tgacccgaat 804061 aaaaaagtgt cagacagcga ttttgaattt attttagaaa caggaagact gtctccgagc 804121 tcactcggcc ttgagccttg gaaatttgtc gtcgtccaaa atccggaatt ccgcgagaag 804181 cttcgtgaat acacatgggg cgcgcaaaag cagctgccga ccgcaagcca tttcgtcctg 804241 attcttgcgc gtacagcgaa ggatatcaaa tataatgcgg actacatcaa acgtcattta 804301 aaagaagtaa aacaaatgcc tcaagacgtg tacgaaggct atttaagcaa aacagaagaa 804361 ttccagaaaa acgatttgca tttgcttgaa agtgacagaa cattgtttga ctgggcatca 804421 aaacaaacct atatcgcgct tggcaacatg atgactgccg ctgcgcaaat cggtgttgat 804481 tcctgcccga tcgaaggctt ccagtacgat cacattcacc gtattcttga agaagaaggc 804541 cttctggaaa acggaagctt cgatatttct gtgatggtgg cattcggcta ccgagtgaga 804601 gaccctcgtc cgaaaacaag atctgctgtt gaagatgttg tgaagtgggt ttaaaagaag 804661 aaagctgctc gcatagcgag cagctctttt ttatgcctga ttcgctctat tctgttttct 804721 cctctgatgt aagtacattg ccgttccgag tgcgctgatc agaaatccgg ccaacaggat 804781 cgagtacatg gatgtggctg tgtccggaag caggccgcca gccggaccgt ctgttcctga 804841 tccgcccgaa ccgtttccac cagagccgtt agtcggttga gtgccgggag gcgtatcatt 804901 tcctccgttt ccgtcagttg gctgttttcc gcctggtttg tcggagcctc cgccatgatt 804961 gccgtcatca ccgcctgtcg gttgatctga cgggaatgcc ggcggtttgt tgtttgaacc 805021 ggaatttaag atcgtgtatt cgctgaagtg gtttgtatat cctgtcacca tatcatcatc 805081 gactgatccg tgacctgtct ttgtgaaagc tttctttttt ctatcgacgt gataaatggc 805141 agggttatgg gcttcttcaa tatcaaacat gcgaagcgaa agctgtacgg gctccttgaa 805201 tgattttatt tcttttcctt tttgcttcac tgtaaagtca tatacatctg acagtgacac 805261 atccaattct cccgtagact tgattccgat tgcagtgtct gcggttttaa ggttcgccat 805321 tggcatcttc atgctgtacc agtagttgaa catcgtcaat gaaggatctg actctctttc 805381 tttcaaaagt ttgacctgat cttttttcac tttaagattg ataggcttct cttgagatcc 805441 ttcatgtatt ccataataga caaatggcgt gttggcattt ttagcataaa tcgcaaattt 805501 gtcttcatca agtgtccagc tgccgtcctt ctgctttgtc ggcaggaata cttctttgat 805561 tcgtccttca actttaggag agaccttgtt tcctagtttt ttcagctgtt cggtgaaaat 805621 ctcataatca acgtagccaa ggtcttcacc atgggaggct tctgtaaaga cagaatatcc 805681 gtctcctccg gcaccgacaa aattatttgt tgccacgcgg taggtatcat ccgtatttat 805741 agcaactttg tctccgttag gcgattcaat tttcacttct aacacacggt gtccaggttt 805801 gttgtttaat gtaaaggtat attcgattcc ggccacctga gggaaagcgc cgccgccatt 805861 ttccacattg cttaggcctt gttcaagggc ttctttaatt tgttttccgg ttaaatcggc 805921 cacgtaaagc gtattgccga acggcatcac gttgagcacc tcgccgagtg tgatatcacc 805981 tttgtcaatg cctgctctga tgccgccgcc atttgttatc gctattctgg cgccggctgc 806041 ttctttcgct tttgccagca taccgtccgc gatgaagttt ccgagattcg tttctttcgt 806101 gcgcacatgc tcacgctggc cgtcaagcgc cacatccgtg tagccgactt tttcattttt 806161 cacgtcctct aattcatttt tgaactgatc gagctcttgt tttgcttctg ggttttcttc 806221 tgtatgttca tcaattggca gcacgctcag atttgattta tctgtttgca caacgccttt 806281 ttcatcaaac gcgacatcaa cgcgccccaa gaattggccg tattcttttg cctgcgccac 806341 gatcgtcggt tcttcgttgt tcacgacctc cattttgtct acgagggtgt gagtgtgtcc 806401 gccgatgatc aaatcaatgc cttttacttt tttggctagc tcaagatccc ggttatgtcc 806461 gatgtgggtt aaagcaataa ttttatttac cttttcttct tcttgaatcg ctttgacggt 806521 gttttgtgct gtttcaaagg catcattgaa tacgatgctt ttgcccgggc ttgatgtggt 806581 ggctgtatct tctgttgtca ggccgaatac ggcgactttc tccccgtcaa cgtctaacag 806641 aatgtaaggg tgaatgccgg cctctttctt ttcacctgcc gtaaaggttt gcggcttttt 806701 gacaaatgat ttcagcttgg gctcatttga cacatctacg tttgcactga caatcggaaa 806761 ttccggcgct tcaaagtgat agcggttcgc cggatcaacg gttgcgctgt ttccgcttag 806821 aaaatcagaa agcaccgtcg ggcctttgtc aaattcatgg tttccgaagg tcatggcgtc 806881 atagcccatc atgttcatca ttttcagatc ggccaaaccg ttccatttag taaaatacag 806941 atcgccggaa aacacatctc ccgcatcaag gagaatattg tgatttgttt cgctgcgtac 807001 ttcgttgatt ttcgtcattc gtctcgctgc atcatcgaga tgggcgtgcg tatcattggt 807061 gtgcatgacg gtcagatccc acagtccgtc tttaggagga tctggatttg aatcatcatc 807121 gaattgcagc ttatacacac catagccttc attcgcagac ttgcctacat aagcgacatc 807181 gtctgcttta tcggcaaatg gcttggccaa aagcgaggat tcaaacgtca gattcgtgcc 807241 ggaaacaggc gcgattgacc agttgttgtc tgcttttgga ttgactgttt tttgttcaat 807301 aatgtaatcc atcagcacct gcctattttc aactgcagag ccgtggacaa ttttatcgct 807361 cgtcagatga gggaacccgc cgcctccgga cgcacgatag ttattggtga ctacgagaaa 807421 ttcctggctt gggctgatcg gcttgccttc ataggaaaga ttgatgatac gggatgaatc 807481 cgcattgatc acttttccgt tctcattgta tttagccggt tttgtcacat cgacctgata 807541 tgtgacaccg tcaatcacgt caaaattata ggagcggaaa ttctcgttca gcaaggcctg 807601 gtcgccgcct ttagctggat caatttgatt gaattggcct gctgacatct ccagccagtc 807661 cttgacctcg ctgcctgtca gcttgacgat ttgaacagta ttatcgtaaa gatacaagtc 807721 accgacattt ttaatcgcaa gatctccggc tggaatgttt gtatagtaat tggctccgtt 807781 tctgccgcct gctttaaacg gcgctccagc ggataaaatc ggcaggttct tgtactcggt 807841 atccttcatt tctttttcag cgtaccactt ttgcgcgtca gtcacgatct gaatggaagg 807901 atcatctttg acctgtgcaa agaagctgtt aatatctgct tcggttttgc cgactggctt 807961 tcggacatac tccagtgtgt tttggtgtgt ttgctgaatg gtgtttgtaa cggtttcgtt 808021 tcttgatgtg acgttgccag caatagattc aatacttcct ttggaatctg ctaccttcca 808081 tgagccgtcc gccttttcaa gcttgaggtc aatcacgcct aaatatttgc cccagctgct 808141 tggcatgacg acaggaatgc cgttaattgt tcccttttcc acattgaact gagcaacacc 808201 cgcatactcg gcggaaggaa agagtccgtg ctgatggccc gagataatcg cgtcaatgcc 808261 tttcgttttg gtggcaaggt caaacacggc gttttctgcg cctgatgatt gcgcctgctt 808321 ttcaatgccg gtgtgggcga gggcaataat gacatctgcg ccttccgcct tcattttcgg 808381 gatcgtttca ttggcggatt ctacgatatc ctgcacctga acttgcccct cgagattctt 808441 tttgtcccat gtcatgattt gcggcgggac aaagcctatg tagccgactt ttactttctg 808501 ctcattaccg ttttcatcaa tgagggtttt ttcattaatc acatacggcg tataacggtt 808561 ttcgccgcta gttgttttga cgttggcatt tacaatcggg aaatcggctc ctttgattgt 808621 gccgtcgaga aagtcgagcc cgtagttgaa ttcatgattg ccaagcgttc cggcgtcgta 808681 tttcagcgca ttcatgacgc tgataatcgg atgggttttc gtgccggaga taatgtcgtc 808741 tttttgatat ttcaccgcgt attcacccag cggattccct tgaatcaagt cgccgttatc 808801 cacaagcagg gtgttagggt tttgctcgcg gtgcttttgg atcaattgcg ctgttctcgc 808861 cagaccgaaa tccgccgttt ctttgtcgct gtagtaatcg taatccatca tgttggcatg 808921 aatatcagtc gtagccaaaa tactcagatg cacctgagga gccgcgcttt cttctgcatg 808981 aatgggtggt gttgggagga ttaggctaag tatcataatt gggggcaaaa gaatacggag 809041 aatgttttcg acgtgtgttc gtcttttctg tattctcacc agttctccac ctttcaacga 809101 aatttgtgtt acagctccta ttgtaagaat attttgtaac tatttgtagg tgtttcttta 809161 tgattattgt aaaagggaga aaaatgagta ttatgtagca gtatcaaacg acaaatactg 809221 ggcatttatg cttatcgttt gtcacaatcg cggaatgttt attttagtgt ggctggggta 809281 gagtgtttta tgtagacata taaagcggga ggttatgaat catggggaaa aaaattgcag 809341 ttgttttaac atattatttt gaggacagcg agtacactga gcctgcgaaa gcctttaaag 809401 aagcgggaca tgaactgact gtcatcgaaa aagaaaaagg aaaaacagta aaaggcaagc 809461 agggaacagc ggaagtgacg gttgacgcgt ccattgacga cgtaaattct tcagactttg 809521 atgcgctttt gattcctgga ggattttcac cagaccagct tcgcgctgac gatcgtttcg 809581 tccaatttac aaaagcgttt atgactgaca aaaagccggt atttgccatt tgccacggcc 809641 cgcagctttt aatcaatgcg aaagcgctcg acggccgaaa agcgacgggc tatacgtcca 809701 ttcgtgttga catggaaaac gccggtgccg acgttgtgga caaggaagtg gttgtttgcc 809761 aggatcaatt ggtcactagc cgcacaccgg acgatatacc ggcatttaac cgcgagtcat 809821 tggcattgct tgagaaataa gaaaaaacgg acgctcttgg gcgtccgttt ttttgttgct 809881 taggcttgag cacctgtcag tttcttgtac ctgtaataca agaaagcagc tgcagccgtt 809941 ccgatgaccg caatgccgaa gtcgaatatg aaaatatggg cgatgccccc cgcttttgcg 810001 ataagccctg ttgcaatcgg cagcagaatc gatgcaagac ttgaagcagt cgctacaatt 810061 ccggtaacgg ttccttttcg cttccagaaa agctctgtca ttaacgtaat ggtaatttga 810121 aacacacccg cagttgaaaa gcctaagaaa aaggcagtga tgtccagcac aactgggata 810181 tgaacggtca gcatgactgc gagcgtacat aaagtaataa taggatataa gagcgttatg 810241 aagacaggtt tgacccatct attcagcaaa acggctaata ataaaacaga tgccagagat 810301 cctatactat aatagctcag caattgtaca gatgctgatt cagctaaacc ggctgccttt 810361 tgcgcgtagc tcgggagcca gatttgagaa accgtaaata aagccgtgga tgtaaaaccg 810421 atgataatca gtgcggtgcc ttccttctga aaaacgggtt cagacaagaa aacgggagat 810481 tcctgttggc cgctattagt tggtttctta tgttttttag gaaacgaaag cgttgataaa 810541 taaataatat tcaggagata gaccgctgcc ggcagataaa aagcaaatcc gtaaaacatg 810601 ctgtggtctg ctaaaaatgt gatcaaaagc ggcaaaagtg cggcccccac agacataaag 810661 gctttaacca agacatttgc cgaaccggaa gcagacggaa agagctcggt tagggccgga 810721 tatgttccgg catccatggc tgaattagcg actccggcta ataaagcgaa cacaaacgcc 810781 agctcatagc tcggtgataa aggaataccg actaaaaaga cggccataat tcccgcagaa 810841 gcgacaacaa gcggctttct gccgatttta tctgatagaa cgccggaaat gccgtatgtc 810901 agcagtttgc caaacccgat agcggcaatg acataactga tgccggtcgg atcggtattc 810961 cactgttttg ttaatgaaga catattggat gcgagaatga tgttgaccat ccccagaaag 811021 aagtagttga tatacattcc ggatgctgtt ttgatagatg tcgtttgcat gcttgtactc 811081 cttcaaatct tattcgaaca ctttgctgtt ttggtttggg gaaatgataa aaaagactcg 811141 ccgagtttcc ggccagtctc cattatttac gaagcgaggc taattcttga gcaatcgcct 811201 gcatttcact tgggctgaat gattcttttt tcatcaccat tctgtgaagg tacgtgaggt 811261 cttcaatctt ctcatcactg aaatcctccg ctttgattac gccgacgttc agcatgttca 811321 gcttttggga aatctcttca atcatttgag ttaatgtttc tgtatttggg ctggacaaag 811381 ggttccatcc tttctatgcg caatataggt atgttttatt ctaacagaat tccatcagaa 811441 aaaaacccta ttctaaaagc aggctgttca ttccaaaaaa gtgaagacat cagttgaaaa 811501 gaaaatgaac atcctactaa gatattcatg aaggtttctt tttagagaaa taggggcaaa 811561 gaatagggag gttgcacatc atgataagcg tgttatttgt ttgtttaggt aacatttgcc 811621 ggtctccgat ggcggaagcg atttttaggg acctggcagc caaaaaagga ttagagggga 811681 aaatcaaggc ggactcagcc ggtattggcg gctggcacat cggcaacccc ccgcatgagg 811741 gaacgcagga gatattgcgc agagaaggaa tcagctttga tggcatgctg gcgcgtcaag 811801 tcagcgaaca ggatctggac gattttgatt acatcattgc aatggatgca gaaaatatcg 811861 gaagtctcag aagcatggcg ggttttaaaa acacctcgca tatcaaaagg ctcttggact 811921 atgttgaaga ttcagatctg gctgacgtac ccgatcctta ctacacaggg aactttgaag 811981 aggtctgcca attaatcaaa acgggctgtg agcagttgct tgcatccatt caaaaagaaa 812041 aacaattgtg agtgaaagga gaatttgcat gaacaacgaa cgtttaatgc tgaaagggat 812101 atttctcgga gctgcggcag gcgcggcgtt atcactgctc cataagccga caagacaggc 812161 gtgcgggatg agatggctga catgcaagca taaactttca ctgtacaaaa gcaacccaga 812221 gctgttaaaa aacactgtca tcacaaaagt ggatgaggcc aaaaagctcg cccgaacgct 812281 ttcaaaggaa gtcgactttg tgaaccagca ggtgaaagag ctgaagaaaa caacgccgca 812341 agtgatggaa ctcgtgcaag aaacgaaaga gcatttttca aaaaaatgat caaacatgcg 812401 aggtgagacg acatgagttt tttgaaagag cttttcagca gatacaccct tcatgaagga 812461 caaagtaaat cagcggagct ggcgtatttt tttctattgt cactgtttcc gtttttgatt 812521 tttatgctga cgctcaccgc gtatcttccg ctttctaccg atgatgtttt aggagtcata 812581 gaacaatatg ctcccgccag tgcgatgtca ctcgttgaat ccattaccca tcaaacctta 812641 aataatcgaa atggcggttt gctgtcattc gggattatcg ccgcattatg gtctgcgtct 812701 aatggaatga atgcgatcgt ccggtcgctg aaccacgcgt atgatgtgga agaaaaccgc 812761 tcttttatca ttgttcgtct aacctcgatt tttttgacga ttgccatggt atttacgatt 812821 ttagtggctt tgcttctgcc ggtatttggc cgggagattg gaaggctcgc ttctgacttt 812881 gtcggcgcgt cggatctgtt tttatccgtc tgggccgcca ttcgctgggg tgtcagcccg 812941 cttgtgcttt tgattgtttt ttccgcgctg tatgtgattg cgccgaacaa aaagctgtct 813001 ctccggtttg tcatgccggg tgcggtcttt gcgactatcg gctggatcat tgtcagcaca 813061 ttgttttcat tttacgtcag cacgtttgcg aactatagcg ccacttacgg gagcatcggg 813121 ggaatcatcg ttctgatgat ttggttttac ttgagcggca ttttaattat cctaggcgga 813181 gaaatcaacg ctcttttaca taaacgtaaa aagcttcctg atgaaaatcc ctaccattag 813241 cgcaccctat aaacgaactt cggttcaaaa agaagtcggg gggatatcgt gatgaccaag 813301 catacgaaaa aaggcggaag ccataacaaa caaaactcga aaagcaaatc gagccataaa 813361 acaagcggaa gcgccaacgg acaaaacggc taccattagc ataaaagcct cctgacatga 813421 tgtcgggagg ctttttgatt aagaagatga agaataggtt tcagccggtg accagctttt 813481 cggtttgccc agcacaaggg ccagccacac agagctaagc gtgagagtaa tgaagtagaa 813541 caagtttgcg ctttcaaatg tctgcatata ccagccgccg gcaactgggc cgaggatgct 813601 accgagactg aatgtaatgc cgcaaagcag gtttcccgcc ggcaggaggt gaggcggaag 813661 aaggtctgtc atatagctga tgccaagtgt aaaggttgat ccgactgcca ttcctgcaat 813721 aaaaaagcag ccgccgatca cgtagggcga aggaaataca ccggcgatga aaaagcaaag 813781 agccccagtc agtaaaatca ccagcagcac attccgcctg ccgtatttat cgctgaggat 813841 gccgagcgga aactgaaaga taatgcttcc aatcgcaaat gcgggaagga tgatcgctac 813901 tgcgtctact gatatcccca aacggagcgc gtacaccgga aagcttccgt tcagcgccgt 813961 ttccagaaag ccatagccaa atgtaggcat aaaggcaacc cacccaaaca gcatggcctg 814021 ataaaatcgc ctgaaactat tgtctgattt ggtttcatga ggactggttt ccgggtatgc 814081 attttgtaga aagaaaacaa aaagccacgc aaacagactg atgcagccgg acacgataaa 814141 aggaagcgac ggactcagct tgacaagcgg caccatgaac gggcctgcgg caaagccaag 814201 gccaaaggaa agcccataaa tagacaggtt tcttccgcga ttttgttttg atgacatgga 814261 ggtcacccac gtttgcgtag aaaagtgaag catgtggtcg ccgattccaa tgaacaggcg 814321 aagcaggaac cagacccaaa ctgactgaag ccaaataaat ccgaataagc ttaaaatgac 814381 aatgcttccg cccatgacga tcagcggctt gaacccgagc tttctgagcg gtgcttccat 814441 aaacggcgaa gccaaaagca caccgatata cagcccggtc gcgtgcaggc cgttgatagc 814501 agcggattct ccatttgttt caaaaatgat tgaaatgaca ggcagcagca tgccttgtga 814561 aaacccggaa atggaaacga gcaagacaag gataaagaaa tgaaatcgtg acatcgtgtc 814621 agttctcctt atatggaatc tatgttgatc gtacaacgtt ttccaaaagc aggcaacctg 814681 aaaaaagcct atatcacgct atacatttgc cctcgtgtaa tcatgaaggt ttttgtgaag 814741 aataaaaata aaacaagtca taaaaaagga gctatttcac catgaatcgt atctttttta 814801 ttttagtggc ggccggtgtt ccgctttctg tgattggcag tttgatgcat tggccttccg 814861 cggttctatt tgcagtttat tgcgtgacga ttatcgcgct tgcaagctat atggggaggg 814921 cgacagaatc actgtccatc attgcaggac cgcgtatcgg cggtttgttg aatgcaacct 814981 tcgggaatgc ggtggagctg attatttccc tttttgcatt aaaagaaggc ctgacaggaa 815041 tcgtgcttgc ctctttaacc ggttcagtgc tggggaacct gttgctggta gcgggcctat 815101 cgttttttgt cggcggttta aaatataagc ggcaggaatt taatatccat gatgcccgcc 815161 ataactccgg gcttctgatt tttgccatca ttgtcgcctt tgtgattccg gaggtattct 815221 ctgttggtat gggaaacgcc agcaagctca atttaagcat cggcatcagc atcattatga 815281 ttctgttata tgtggcggcg ctgtacttta aacttgtcac gcatcggggc gtttatcagc 815341 cgaataatgc cgctcagact gaagaagagg aagagccaga atggtcaggg aaggttgcga 815401 cgattgtctt gtttgcggca acgattgtgg ttgcatacat atccgaaaac ctggtccata 815461 cctttcactc ggtggctgaa cagttcgggt ggagcgagct gtttattggg gtcatcatcg 815521 tggcgattgt aggaaatgcg gcggagcatg cgtcagcgat tattatggcc ttcaaaaata 815581 aaatggacat tgctgttgaa attgcagtag gctctacgct gcagatcgct atgtttgtcg 815641 caccggttct cgtcatctgt tctatctttt ttccgacaag catgccgctt gtatttacat 815701 tgcctgagct cgtcgcgatg gtatcagcgg ttctcttgat gatcgcgatt tcgaatgacg 815761 gggattccaa ctggtttgaa ggggcgacac tgcttgctgc atatgtcatt atggcgatcg 815821 gctttttcct tctttaacct gaaaaaatga tggataacaa caaagcggga tgaaaagact 815881 aagggaaaat gccatagaaa gagtgatatg atgaaaaagc tatttcattc cacacttatt 815941 gtgttgttat tctttagttt tttcggcgtt cagcccatcc acgcgaaaaa gcagtttaag 816001 gttcctaatt ctgtcgcaag catttcaaag gaaaacacgt atccgaatgc ttcacaggat 816061 cagccaatgc ttcagccgag caagctggca aaggaattgc tcgatcattc tgaggtaaag 816121 attgaaaatc cgcatctcat caaaatgctg aatgaatcca acatatccgg cacaccgctt 816181 gcagtagggt accgggcgac aatatttctc gggaaatggg cgctcggcta tgaatcaaat 816241 gaaacagtcg caaactggga atataaaaaa atcaatacaa accgtgcgga taaccgcggc 816301 gggaaagaaa cggctgaaat gcattatgcc caggaacagc agtacagagt gaagggcggc 816361 ttgacagcta aagttccaaa tgctgaagat gtcaaaagca tgatgatgca aaaagcaatg 816421 aagaaaacga acctcccgct tgcatttgag acggtcatcg gggctggcac aaaacgggat 816481 cagatttata aagtcgctcc taaaaaaatc ggttatctac atgcatatgc accggctgtg 816541 aatgaaaaag gaaaagtgac ttacggagaa gtgtacttag tgctgaaagg aaataaacga 816601 aaactcgtcg tgaaaaatgt cacgtcacag ggaatcggcg cgtggattcc ggttcaagat 816661 catgtcacgt ttggctttca gctttcctca ctgccaagat aaataaaaaa ctgattccaa 816721 ctcggaatca gtttttttgt ttattgggtt ctctcgattc ggaccgcttc ctcaagcatt 816781 tgcacattgt tttggtagag ctggcgaacg agaacccgtc ttactgcaag gctggcactg 816841 aaataatcat catctttcac catgccttta accgtaaatt cgacgccgcg attgatttta 816901 ttcaatgcgg tgatgccgtg gatttgaaac ggttctgtcg gattgccgaa ttcatcccgc 816961 ttcaatgaat cacgaagctc ttcattcagc atgtcacatg cctcttccaa cacgctgtac 817021 acgcggtccg gatcttcttt aaagctgata agaaaggatt cggtaatccg cataaaatca 817081 atattatagt tctctatttg tctgacctcg ccgttgctga tggtgagcag cttcccgctc 817141 cattcccgga tttgcagcga gcggaggccg atttcctcca ctgtcccgtt gaacaagttg 817201 ttgacggtga cataatcgcc tttgtgcagc tggcgttcat atattaagaa tacaccagcc 817261 agcacatctt tgatcagcga ttgggcgcca aaaccgatca cgatacctgc tacgcccgcc 817321 ccggccaata tcttgccgaa atcatgcaca aataaagaaa taacgtaaaa gataaaacca 817381 attgttgccg tatactgggt gacagaacgg acaaggcttt caatcgtttt ttcctttttt 817441 tcttcaataa agtccgtccg tttaaaaaat agctgtacca gccggttgat gataaagaca 817501 ccgatccaaa ggataacggc aacgaggaga atatcgacga ttttattttg aaaaatctcc 817561 gtaagtgttt ctttcatccg catctaactc ctggcttgac gttttgtgaa gtctgtatcc 817621 tgataataac tgtttttgac aagaacattc ggtccgaggc accggacatt cgggcagtgg 817681 caactcagtt ctttcgcaag cttggtctct ctccactttt cataggcgga agggaggctg 817741 tccgtctgaa tgttgccaag cggcggggta tcaccgaaat cggtcacgat aatgtttccg 817801 tcgaaaatgt tcacattcag gcgggatcgg ccgtcagggt catttcgcac tgtgacgttt 817861 ttcgccgcgc gaagccggcg aagcagcttt tggtcgtctt cgtccggact gcaggcataa 817921 aacggcagcg ttccgaacag catccacgta ttttcatcac gaatatccag caagcggtga 817981 atggcctgtc tcatctcttt caggctgagg gattcaagag cgcttgcgaa atcgcttgga 818041 tacattgggt ggacctcgtg acgctgacat ttcatatctt ctgtgatttg gcggtgaata 818101 tgctcaatat gcggaagtgt tcgtttgttc agcatcgttt ccgcagatac cattactccg 818161 gcatccacga gcgtgcggct gttttcgatc attttttcaa aatagcgcgc gcgctgttcg 818221 aaggtcggtt ttctgtccat catggcaaag ccgatttcag caaaatcttc aactgttccc 818281 cagttatgtg aaatatgtag cacatcgaga tacggaatga tccattcgta ccgctcgatg 818341 tcgagggtca gatttgaatt aatttgtgtc cgcacacccc gttcatgggc atatttcaat 818401 aaaggaacaa catattcttt tactgatttc aacgaaagca tcggctctcc gcctgtgatg 818461 ctgatggatc tgaggcgcgg gatttcctcc agccgtttta acagaagatc tattggcaga 818521 gcattcgggt ctttaggctg caatgtatag cctacagcac aatgctcgca tctcatattg 818581 cacagtgtcg ttgttgtgaa ttcaacgttt gtcagctgca tgtctccgta ttggtcaaca 818641 tccatatagg cttcccaagg gtcaaactcg ggcgtaatcg gacgcagctt cgtgttttgt 818701 gtcatgacta tctaactcct ttataaatgg gcatactaac gctgccaaca gttaatttta 818761 gacctgattt gccaagatcg caagtagcgc ggcgattgaa aaacggcaaa aaatgagcta 818821 ccataataaa aaatgaatgg aggaacagaa tggggaacgc cgtaaacaat aaagatcagc 818881 agattgatta tttaaagaac agacttgaca tgtttatgaa cgtcatcgat tcattagacc 818941 ctgaagcaac cgacgttgaa gatatagaca ggcttatcag catgcttgat gacctggaag 819001 ccaaatacga acgttttaaa aaagattggg aataaaaccg cgtgcccgcc gcggtttttt 819061 tattggcata aagcaacagt ataaaacaaa gtctctatct gtaaaataag aaaaaatgca 819121 gaaggagcgc tggccatgaa gtggatgtgt tcaatatgct gcgccgccgt attgcttgcc 819181 ggaggtgcag cacaggcgga agcggtgccg aatgagccga ttaattgggg ctttaaacga 819241 agtgtcaatc atcagccgcc agatgccggg aagcagctga acagtttaat tgaaaaatat 819301 gacgcgtttt atttagggaa tacaaaggaa aaaacgattt acttaacgtt tgataacgga 819361 tatgaaaatg gctatacgcc aaaagtgctt gatgtcttaa aaaaacatcg cgtaacagga 819421 acgttttttg tcaccgggca tttcgtaaag gaccagcctc agctgatcaa acgaatgtca 819481 gatgagggcc atattatcgg caatcattcc tttcaccatc cggatttaac gacaaaaaca 819541 gctgatcaga ttcaggatga acttgattca gtcaacgaag aggtttataa aattacggga 819601 aagcaggaca acctgtattt gcgtccgccg cgcggcgtgt tcagtgagta cgtactgaaa 819661 gaaacgaaac gcctcggcta tcaaaccgtt ttctggtcgg tcgcttttgt tgattggaaa 819721 atcaacaacc aaaagggaaa gaaatatgcc tacgatcata tgatcaagca ggcgcacccg 819781 ggagccattt acctgcttca caccgtatcg agggacaatg cagaagcgct ggatgacgcg 819841 attacagatc tgaaaaaaca gggctacact tttaaaagca ttgatgatct gatgtttgag 819901 aaagaaatga ggctgccgtc tttgtaaaag agaaagacct ctccttaaac ggagaggctt 819961 ttctttattt tatacattta atcagtgcgg cccagtccag atccccgaag cctttctcaa 820021 tcccgctttc aaaatggctc ttggccagct cggcaagagg aagatttgca gaaacccgtt 820081 ttgcggcggc gagtgccagg ttggtatcct tcagccctaa agacattttg aagccggccg 820141 gctcaaattt ctgctcggcc ataatggttc cgtaattttg atagactgga gaaccaaaga 820201 gcgcgctggc gatttctaaa aattgttttt gttctaagcc gtatttctcc atcattaaaa 820261 aggattcaga taacgcctcc agcatggaca caagcaagaa attaatgctg attttggctg 820321 catttgccgt cttgctttct tcgccgacgt caaatatctg ctggctcagg ctgtcgagca 820381 gaggcttggc agcttgcttt gcttccgccg gtccggctgt tatgatacgg agcgcggctt 820441 tggctgcggc atccggtctg ccaaggacag gagcggcgag aaaaaattgt cctttctctg 820501 catgagccgc tgcgagcttt tctgagaact caacactgat tgtgctcatc gagatgtgta 820561 tgccgttctc tgctaatcct tcaagcagcc cgtcttctcc gaatgtcacg gtgctgacag 820621 aatcatcatc tgcaagcatt gtgatgacaa tatcagcgga ctttgccgcc agccgcggcg 820681 tatcagctgc ctgtgcgcct tctgtgacaa ggtcttctgt cttttgtttc gtccggttat 820741 agacagtcaa ttcgtagcct gcttgaagaa catttcgggc aatgggctgt cccatattgc 820801 cgagtccgat gacagcaatt ttcaatctaa tcactccctg aatatttttt ccattataaa 820861 caatatgaac agaatatgca tagcgatcgg cttacaacaa aaaagaacag ctgctcgctg 820921 tcctcattta aaaatattga accatccttt atgtacaaac caaatcagca ttccaatcac 820981 aagcgcggcc atcaggccaa gtacagcgaa atatccgtat ttccaatgca gctccggcat 821041 aaagtcgaag ttcataccgt atacaccggc aataaaggtg agcgggatga aaatggttga 821101 tacgatcgtc agtgtcatca taatcgcatt catccggttt gagtttagcg tcacgtagct 821161 gtcacgcaag tcggacgtca tgtcacggtt ggattccaca atttcagaca actttaacaa 821221 atgatcatat atgtcgctga aataggcttt cgtttcccgc tgctctttca catggtcaag 821281 gcttaaaatc cggtagagca aatcacgcat cgggataatc gtccgtctca aatgcaatag 821341 gtctgttctg agatcaaaca cctcgttcat cagcgttcca tacgttttgt ggggacggct 821401 ttcttcaatt tcattcagcc ggtcttcaat tttatacacg agaggaaaat attcatcaac 821461 aagctgatcc atgatcatat aagaaatatg cccgggccct tttttcaata tgtccggtga 821521 agcatacaaa cgctcccgga ctttagcgat accgggcgtt tcgtgtaaat gaaaggtgac 821581 gacaaatttt tcgccttgaa agatatcgac ttcctccgtc tcaagtgttt ccttattcag 821641 cgcatgaatc acgtaaaaac gatagccgtc ataatggtca agctttggcc gctgcatatg 821701 ctggaagcaa tcctcaatgg caagcgggtg aaaatgaaaa aaatctctca ataacgccgt 821761 ttccgtatcc tccgggccgt aaaaatcaac ccagtaccat gcaatatcag gctgttccac 821821 tcgttcgatc ggtatatttt tcagcagctg atgctctgtt gtgattgcgg taatgttgat 821881 cataaacaac cctccacctg ccattatatc atgcggtctt tatgagaaaa gtatacggta 821941 ctctctgcct aattccagcg gcatgttata ctgaacaaaa acggaaaaaa gggtggatct 822001 catgtggaag gaaaaagtat ctgtcacgcc tccgtatcat tttgaccgcg tgctggacag 822061 gctgtcttta gaccccctca atgctgttga tcgagaggcg agggaagtcc gtgtgccaat 822121 cagaaatcaa gcgggggacg tatgtattgt aaaggtacag gcgttaggcc atgcgggcga 822181 gcctgagttc ctcgtcagcg gggaaacgga tcagggagaa atgatgaagg aaatcaagcg 822241 gatttttcaa tgggaaaatc atttgcagca cgttctggat catttttcaa aaacgagcct 822301 gtccgccatt tttgaagagc atgccgggac gccgcttgtt ctggactaca gcgtgtacaa 822361 ctgcatgatg aaatgcatta tccaccagca gcttaatctt tccttcgctt acacgctaac 822421 agaacggttt gttcatgcgt ttggcgagca gaaggatggc gtgtggtgct atccaaagcc 822481 ggaaacgatt gcggaactcg attatcagga tctgcgtgat ctgcaattca gcatgagaaa 822541 agcggaatac accattgata catcaaggat gatcgcagaa ggcacactca gcttgtcaga 822601 gctgccgcat atggcggatg aagacattat gaagaaactg atcaaaatca ggggtatcgg 822661 cccgtggacc gtgcaaaacg tcctcatgtt cggacttggc cgtcccaatt tattcccgct 822721 tgccgatatc ggcctccaga atgccatcaa acgccacttt cagctggacg ataagccggc 822781 aaaggatgtc atgctggcga tgagcaagga gtgggagcct tatttaagct atgcgtcttt 822841 gtatttgtgg aggagtatag aataattcgt ctgacaatga aggaaatcct gcaaacgtgt 822901 tatactagaa agatgtgaaa aaaccatttc actttctgcc atccgcagaa agcttcatat 822961 agaaacggag agaacaacgt gaaccaacaa aagaaacagg cgcccgtcga actgaaggtc 823021 ggacaaactt ttccgctgac gattaagcgt ctcggcatta acggagaagg tgttggctat 823081 tttaagaaaa aagtcgtctt cgtgcccggc gcgcttcctg gcgaagaagt tgttgtgcag 823141 gccacaaagg tccagccgaa gttttcggag ggccgcatta agaaaatccg caaggcatct 823201 gagcaccggg tggcaccgcc ttgccctgtt tatgaacaat gcggcggctg tcagcttcag 823261 caccttgcat acagccagca gcttcgggaa aaacgtgata tcgtcattca gtctcttgaa 823321 cgccatacga agtttaaagt tgaaaacatg gaaatcaaag aaacgattgg catggacaac 823381 ccgtggaatt accgcaataa aagccaattc cagatcgggc gctcgcaaag cggcagcatc 823441 atcgccggct tatacggcct tgattctcat gatatcgtgc cgattaaaga ctgtatcgtt 823501 cagcatccgg caacgaacaa aacaacaggc atcgtccgcc gcattttaga ggacttcaat 823561 gtgtctgttt ataatgaaag aaaacgaaaa ggcgacgttc gcacgatcgt gacgagagtc 823621 ggctttgaaa caggcgaagt gcaggtcgtg cttgtaaccg caaaagaaac gcttccgcac 823681 aaggaagaaa tcgtcaaagc gattcaaaag cgattgccag aggtcaaatc cattattcag 823741 aatgtaaacg gggcgaaaac ctcagtgatt tttggtgaga aaacaaaaca gctcgccgga 823801 aaaacagtga ttcaagaagt gctcggcgac gtatcttttg aattgagcgc ccgcgctttc 823861 ttccagctca atccggaaca gaccgtcaag ctgtatgatg aagtgaaaaa agcggcgcag 823921 ctgaccggaa aagaaaaagt cgttgatgcg tattgcggcg tcggcactat cggcatgtgg 823981 gttgcggacg gagcgaagga agtccgcggc atggacgtca tcaaggaatc aattgacgat 824041 gctaagaaaa acgccaaaaa acacggcatg gcaaatgcca catacgtaac aggaacagcc 824101 gagcactggc tcccgaaatg gacgaaagaa ggcttccgcc cggacgtcgt cattgtagac 824161 ccgccaagaa cgggctgtga cagcacgttc ttggacacga tcaaaaaagt caaaccgaaa 824221 cgctttgtct acgtttcctg caatccatcc acgcttgcga aagatttgca gacgctgtcg 824281 aaggactatc gcgtggacta tattcagcct gtcgatatgt ttccgcagac ggcgcatgtt 824341 gaagcagtgg cgaggcttgt attaaaatcg tctaactaaa aagaacattt cccagtcata 824401 aaatagtttt cctaataaga cctggatttc ggtaaaataa acaattccga tttccgggtc 824461 tttttcgtgc gcagctcttg tcctaacggt ctgttctcaa ttttatcttc cttcttttcg 824521 cggagatctt tattttaact ggcgaaaaga attgaaaaaa cgtgttgaaa agcaggtgaa 824581 aaaaagcgtt atttaaccgg aaaaatatcc tcccagtatg tttaaaatac atgagtagaa 824641 tgatgtaaaa tcatagatgt attttcataa tttgtaaaat tatatattga cttgcagtta 824701 ttacgtgtga aatattgatg ataggaatat aaggaaagta tggcgtatat catttcaaga 824761 gtcattcgat gtaaaaagtt gaaacattgt aataaatgaa agaggtgaaa atgatggcca 824821 accccatttt aaaatgcata acgtatgagc actacaacaa ttaaataata gtgccgagac 824881 gataacaact attacagtaa tacctacaat ggttatatcc ttgcgacaat catgcttcat 824941 aatataatga ttttagattg acacttggct aaaaagtatt gcagagaagg aaatggataa 825001 ttaaatggat aaagtatata aaagaagttg gtttcaaaca tttttggcat ttttagtatc 825061 tcagctttat tttaattttg tagaattaac gggatggggt cctaagtata gagaaatgaa 825121 tggattccca gcaaacatag ttgaactaga tttctttcaa acatatcttt cattctatga 825181 taatccatgg tttaatatta ttactgtttt cttgggagtt ttcactatta tacaaataat 825241 tacagggata acaaaggata ttcgaaatta aagcaataac ttctgatgcc ttatttaatg 825301 atgaaagaaa atgtacactt tcttaattat cttatgagtg aagactgcga cacttagtca 825361 gcagtctatt ttatggttct ggatcaggat taccgaatta taaccctata caaatatata 825421 gtaggttgcc acttgctgcg ttggttattt tctaaatcat gagcaaatcc caaatgattc 825481 agattgaagt tcttgaattc ttttaaataa gggtttattt tctcttctca tcctctttac 825541 tccatgtgat tcacaagtgg tagcagctta agtaggtttt ttcattctct tgagtactca 825601 gttataccac ccccaactca atttgcttta tctctattag tttttccgca aatatgatat 825661 agagatacgg atatggtgta gtgttaaata tcttatcttc aataacaggg caattatttt 825721 gcgttggtaa tatggagaac tcatatgata ttctatttag gttggaatcc tttttatcca 825781 aaaagttcaa aagcaaggcc actaagaaag acgaaggtca gcgccagtta accagaatat 825841 aaaaaatagg gtagataatc atcccacgtg aaatcttcaa aatttactat agattgataa 825901 gaaatgcttt cgcatgcgat aagtgtaaaa gaagcatggt cagtttttaa tttgggataa 825961 aggttcagcc gtatcccata atgaaaggat ttgatttttg ttatgacaga aaatttctgg 826021 cgtgaattac cacggccgtt ttttgtactg gcaccaatgg aagatgtgac agatgttgtt 826081 ttccggcatg tagtaagtga agcaggcaga ccggatgtgt tttttacaga gttcacaaac 826141 tcagagagct attgccaccc ggatgggaag gatagcgtgc gcggccgttt gacttttaca 826201 gaggatgaac agccaattgt ggcccatata tggggagata agcctgaaaa cttccgtaaa 826261 atgagtattg gcatggcaga gttaggattt aaaggactag atatcaatat gggctgccct 826321 gtgcctaatg tggcggggaa tggaaaggga agcggcctta tttgccgtcc tgcagttgcg 826381 gcagaattaa tacaagctgc aaaagcaggg ggattgcctg taagcgtgaa gacaagactt 826441 ggatacacgg atgtggatga atggcgcgag tggctgacac acattttgaa acaggatatt 826501 gcgaatcttt ctattcatct gcgtacaagg gcagaaatga gcaaagtaga tgcgcattgg 826561 gagctcatcc cagagattaa gaaacttcgt gacgaggtgg caccagatac attgctaaca 826621 ataaacgggg atattcctga ccgtcaaact ggcttgaaac ttgctgaaca atacggcgtc 826681 gatggaatta tgatagggcg cggtattttt acaaatcctt tcgcttttga aaaggagccg 826741 aaagagcata gcagcaagga attgcttgat ctcttaaggc tgcatctgga tctccatgat 826801 gaatattcaa aagaagaagc ccgtccatac aagcctcttc ctcgcttttt caagatttat 826861 ctccgcggat tccgaggggc aagtgaatta agaaatcaat gcatgaacac aaagtcaaca 826921 gatgaagtgc gtgcattgct cgacgacttt gagagaaagt atcttgatgg gatagagtaa 826981 cagcagtgct tgattcaaaa aaggctaaca aaataaaggg atttttacac aattcttgac 827041 taaaataaac ctggattttc ggtaaatccg ggtctttttt gtacgcagct tttactcagc 827101 ctgtcttttc tctaatttat tgtaagaaaa taatggtata tttagtggag atatcatata 827161 aagggggaga ggaaaatgaa acggctatgc atcatcccct gcggcaagaa aaaaatctgg 827221 gatgtccagc ctgatgccgg gccggtaaga gcagaggacg cttatctcag cccgtttcat 827281 caggcgtgcg agcggtatgc aaaaacattt ttcgatgagt gggtgatttt gtcggcgaag 827341 cacgggttcc tccgccctga tgatctcgtt tcgggaaatt acgatgtcac ttttggcacc 827401 ggtcatccgg aaatcatgac agcggacgag ctgcgccgtc aatttcacga aaaaggcttt 827461 tctgatatcg aagagctagt catgcttggc ggaaaaaaat atcgaagcgt tctaaacgcc 827521 gtcatcggag aacaccagca tatcagctgg ccgctatcat catacaaagg cataggctat 827581 atgctccaag cgctgaaccg ggctgttgaa gaaaagcatg aactgtagca cgtacatatg 827641 aggaaaagag tgggaacatg aaaaaacttg tgtttggctt gcttgccatt gtgttattcg 827701 gatgcggact atatatctat catgtatggt tcggtgatcc attttcgaaa aatgctgcag 827761 aacagaagct agtgtcttat gtgaaacaaa cctatcctaa gaaagaaatc aagatcacga 827821 atggggtata taacgctaaa acgtctgaat atgtatttga agcaacctcc caatctcatc 827881 gctacccaat gtgtacgaag ggatttctgc atcctaaagt aacgtgcgat ggaattgaag 827941 aagcgtatac cgaatcagta gcaaaacatg taaatgaaga agcaacgaag gcaatcgaag 828001 cagatctgaa aaaagcggtt cctcgattta taaaagctga tgctgctttg agtatcgaaa 828061 acggacagtt cacgttagat acaaaatgga acaaaaagct ggctgaaaaa gcgcctatga 828121 gcatgacgat tcagttagac gccagcgggt tatcaaaaac agatgccgca aagatggcgg 828181 aaacggtcag aaaaacgctt aatgaaaagg gatatacata ctcaaacggc acgatagact 828241 gtatgcagaa ggacggggac ggcggtattg gatatgtcaa atattcaatt gattttcttt 828301 caaaagcagc tattcagtca aacgatgcag aggaactagg aagttaaaaa gatttccaag 828361 gaaataaata cgtcgatcat tgtcaaaggc cgggtgatat ccggtctttt ttttgcatgc 828421 tgtaaaacga gacaaatgaa tcagtttgag acaaaacgag acacacgtct caaactgtct 828481 ccaaagtgaa gatgagaaga ctgattttac gggctcaaaa gactggcaca cttcttgcat 828541 ttataatggt gaaccctaaa tagaaggagg cgcacaaaat gaaattgtta aaacgagaag 828601 gcttgtcatt aactgaggaa aaagcgctgt ggatgtacca aaagatgctg gagatcaggg 828661 gctttgaaga caaagtgcat gaactgttcg cccagggagt gcttcccgga ttcgttcatt 828721 tatatgccgg tgaggaagcc gtggctgtag gggtgtgcgc tcatttacat gatggcgaca 828781 gcattacaag cacccacagg ggacatggac attgtatcgc caaaggctgt gacctggacg 828841 gcatgatggc ggaaattttc gggaaagcga ccggattgtg caaaggcaag ggcggttcta 828901 tgcacattgc ggatcttgat aaaggcatgt taggcgcaaa tggaatcgtc gggggcggct 828961 ttacgctcgc atgcggatca gcgctcacgg ctaaatataa acagactaaa aatgtaagcg 829021 tttgcttttt cggggacggg gcaaataacc aaggtacctt ccacgaaggg ctgaatttag 829081 cggctgtatg gaaccttcct gtcgtatttg ttgctgaaaa caacggctat ggcgaagcta 829141 ccccatttga gtacgcatca gcctgtgatt caatcgccga tcgggcggct gcttataaca 829201 tgccgggggt tacagttgac ggcaaagata ttttagcagt ttaccaggca gccgaggaag 829261 cgatagaaag agcaagaaac ggcggcggcc cgtctttgat tgaatgtatg acctacagaa 829321 actacggcca tttcgaagga gatgcccaaa cctataaaac gaaggatgaa agagttgagc 829381 accttgaaga aaaagatgcc attcaaggtt ttaaaaacta ccttttaaaa gaaacagatg 829441 ctaataagct gtcagacatt gaacagcgtg tcagcgaatc gattgaaaaa gccgtctcgt 829501 tcagcgaaga cagcccatat ccaaaagatt cggagctgct gacagatgtg tatgtgtcat 829561 atgaaaaagg aggaatgtaa gagatggcga gagtcataag catgtcagac gcgatcaatg 829621 aagcaatgaa gcttgcgatg agaaaagacg aaaatgtgct tttgatcggt gaggatgtcg 829681 ccgggggagc ggcggtcgat catttgcagg atgatgaagc atggggcggt gtattagggg 829741 tcacaaaggg actcgtacag gaattcgggc gtacaagagt gctggacact ccgatttctg 829801 aggcaggcta tatgggagcg gctatggctg cggcatcaac cggtttgaga ccgattgccg 829861 agctgatgtt taacgatttt atcggcacgt gctttgatca ggtgatcaac caaggggcga 829921 aattccgtta tatgttcggc ggaaaagcgc aagtgccgat taccgtccgc accacatacg 829981 gagcagggtt ccgggccgct gcccagcatt cacaatcgct gtatggcctt ttcacgagca 830041 tccctggact gaagacagtt gttccatcca atccgtatga tgccaaaggt cttttgcttg 830101 cagcaataga agataatgat ccggtgtttt tctttgaaga caaaacgtcc tacaacatga 830161 agggcgaggt gccggaagat tattatacaa ttcccctcgg aaaagcggat atcaaacgcg 830221 aaggcaatga tgttacgctc tttgcagtcg gcaagcaggt caatactgcg cttgaagcgg 830281 ctgcacagct ttcagagagg ggcatcgaag ccgaggtcct tgatccccgc agtctgtctc 830341 ctctggatga ggatgcgatt ttcacatcgt tagaaaaaac aaaccggctg atcatcattg 830401 atgaagccaa tccgcgatgc agcattgcca cggatattgc tgcgcttgtc gctgacaagg 830461 gctttgattt gcttgatgcg ccgattaaac ggattacagc gccgcataca ccggttccgt 830521 tttcaccagt gcttgaagat caatatttgc cgacaccaga taaaattgtc agcgtcacgc 830581 ttgaattgct tggcgagccg gcattgaatt aaagggggga cacaaatggc ggtaaaagta 830641 gtgatgccaa aattgggaat ggccatgaaa caaggggaag tatcgatatg gaataaaaaa 830701 gtaggcgacc cggttgaaaa gggagaaagc attgccagca ttcaatcgga gaaaattgaa 830761 atggagatcg aagcgcctga aaaaggaacg ctgatcgata tcaaagtgaa agagggagaa 830821 gaggttccgc ccggcacagc tatctgctat atcggggacg ccaatgagtc ggtgcaggaa 830881 gaggcggggg cgcctgttgc tgaagacaat atgccgcaag ccgtccagcc cgtcaaacaa 830941 gaaaacaaac ccgcagcctc caaaaaagat cgaatgaaaa tatctccagt cgccaggaaa 831001 atagcagaaa aagcaggatt agacctaaaa caactgaaag gaactggacc aggcggacga 831061 atcgtgaagg atgacgtaac aaaggctctt gctgaacaga aaaaagatca agcaaagcct 831121 gtttcggagc agaaagcgca ggaaatcccg gtgacaggca tgagaaaggt catcgctgcc 831181 cgaatgcagg aaagcctggc aaacagcgcg cagctgacga tcacgatgaa agctgatatc 831241 accaagcttg ccactcttca aaaacagctt tcaccaactg cggaagagag atacggcaca 831301 aaactgacga tcactcattt tgtctcaaga gccgccgttc tcgctctgca agctcaccct 831361 gtgctgaaca gcttttatca aaatgagcgc atcatcacac atccccatgt gcaccttggt 831421 atggctgtag ccttggaaaa tggcttagtg gtgcctgtca tccgccatgc tgaaaagcta 831481 tcgctgattg aactggctca atccatctca gaaaatgcca aaaaagcacg cgagggacgt 831541 gcgggaagcg aagaactgca aggatctact ttctccatta caaaccttgg cgcgtttgga 831601 gttgagcatt tcacaccgat actaaatccg ccggaaacag gcattctcgg catcggagca 831661 agctatgaca caccggtgta tcaaggggag gagatcgtca gaagcacgat cctgccactc 831721 agcctgacat ttgatcacag agcgtgtgac ggcgcccctg ccgctgcatt cctgaaggcg 831781 atgaaaacat atttggaaga acccgcagca ttaattttat aggaaaagca ggtgaaaacg 831841 acatgacatt agccattatc ggcggcggac ctgcaggcta tgcggctgcg gtttccgcgg 831901 cacagcaggg cagaaacgtg ctgctcattg acaaaggcaa gcttgggggg acctgcctga 831961 atgaaggctg catcccgaca aagtctttgt tagaaagcgc aaacgttctt gataaaatca 832021 agcatgccga cagctttgga atcgaacttc cggcaggtgc gatatcagtc gattggagta 832081 aaatgcaaag ccgaaaacaa caggttgtca gtcagcttgt ccaaggcgtt cagtacctaa 832141 tgaagaaaaa tcaaatacag gttgtaaagg gaacagcctc ctttctttct gaaagaaagc 832201 tcttgatcga aggagaaaac ggaaaagaaa tcagagaggc ggaccaagta ttgattgcct 832261 ccgggtcaga gccaatcgag ctgccttttg ccccatttga cggcgaatgg atcctcgaca 832321 gcaaagacgc gctttctctt tccgagattc cgtcttcact agtcattgtc ggcggcggtg 832381 tcatcgggtg tgagtatgca gggctgttcg ccagattggg atcgcaggtg accatcattg 832441 aaacagcgga ccggctgatc ccggctgaag atgaagatat tgcccgtctc tttcaggaga 832501 aacttgagga agacggtgtc gaagtgcata cttcatccag attagggcgg gtggatcaaa 832561 cggccaaaac ggcaatatgg aaaagcggtc agcgagagtt taaaacgaag gccgattatg 832621 tgctggtggc gatcggcaga aaaccccgtc ttgacggatt gcagctggaa caggccggag 832681 ttgatttttc tccaaagggc attccggtga atgggcacat gcagacgaac gtgcctcata 832741 tttacgcgtg cggagatgct atagggggca ttcagctcgc gcatgccgct ttccatgagg 832801 gcatcatcgc tgcttctcat gcttccggaa gggatgtcaa aatcaatgag aaacatgtgc 832861 cgcgctgcat ctatacgtcc ccggaaatcg cgtgtatcgg aatgacagaa cgacaggcaa 832921 gaagcatata cggggatgtg aagatcggcg aattttcatt ttccgcaaac ggcaaggcgc 832981 tcattaaaca gcaagcggaa ggaaaggtca aaatcatggc tgaaccggaa ttcggcgaaa 833041 tcgtgggtgt ctcgatgatt ggcccggatg taaccgagct catcggccaa gcggcagcga 833101 tcatgaatgg tgagatgacg gcagatatgg cggagcattt tatcgccgcc catccgactt 833161 tatcggaaac attgcatgag gcgctgttaa gcacgatcgg ccttgcggta catgcataat 833221 aaaggaaaaa gcaggcgcat ggatataagg cgcctgcttt tttattgttg aaagcgcttt 833281 atttttcccc tacaatagat gaaaacggcg tgtaagggag gagcgatcaa ggaaatgaat 833341 tcggtcccaa acgatttgca aacctggaaa cgttttgtga aagacggtgt gcttgacgaa 833401 gcccgattaa gaaaacggat tgcagagtca tggcatcgct gcaaaaaagc tgaggtcaat 833461 ccttatttag aaaaaggccc gaaggtttta cagcaaacgg agctggatca gcagtcaaaa 833521 aaacattcat tcttcttgac gaccgcaaag ccttacctcg aaaaactgct gcctgccata 833581 aaagaaatgg aaatgatggc gctgttaatt gattcagacg gtgttgttct ggcattggac 833641 ggccatccgc gcgcgctcta tgaagccaaa cgcatcaatt tcgtcgaagg ggcatgctgg 833701 acagaaacgg ctgtcggaac aaatgcgatt ggcacggcgc tccacatcag cgagccggtt 833761 gcaatacaag gatcagagca ttactctatc gcttcccatc tttggaactg ttcagctgct 833821 ccgattcacc atgaggatgg cagccttgcg ggtgtaattg acatatcatg cccggcggca 833881 ggcgcgcatc ctcatatgct tggtattgcc acggcgattg cctatgccgc tgaacgggaa 833941 ctcgcagcta aaagccgtga gaaagagctg gagctgatca gccgttttgg ggagagagct 834001 gcatccagtg tgccgatggt gctctgtaat accaagcagc acatcatcag tgcgagcatg 834061 ccgattcgaa cctcaatgcc ggattggcag ggccggcacc tgtacgagtt gaaggaacgg 834121 ggctattcaa tcgaaaatgc tgtcaccata ggagatggcg gcacttgttt ttatctttcg 834181 gaacaaaaga aaaagaaggc gtttcgattc aatggagtga tcgggcaaag cggccgatcg 834241 caagcgatgc tgatgcacct tgaacgagca gctgcgacgg atgcatcggt ctgtttgtcg 834301 ggtgaaacgg gtacggggaa ggaggtcgcg gctcgcgcgc ttcatgagaa cagtgagaga 834361 cggcacggtc cgtttgttgc tgtcaattgc ggagcgattc cgtctgattt gattgaaagc 834421 gaactgttcg gatatgcaga gggcgctttt acgggagcga aacgaaatgg ctataaaggc 834481 gcctttcaaa aagcgaatca aggcacatta tttttagatg aaatcggaga aatttcccac 834541 tcgatgcagg ttgcactttt acgggtgctt caggaacgca agataacgcc aatcggcggg 834601 acgaaagaaa ttccggttga tatcagagtt attgccgcca cacattgtga tttacgcgag 834661 cttgccgaaa acggaaaaat cagagaggac ttgttttacc gtcttcatgt ctatccaatt 834721 gaactccctc cattacgcga tcgcaccgag gatatcccgg atctctttga gtactacaaa 834781 cagaagaatc attggccagg cgatcttcct tctgattttt gtaatgtgct gaagcaatgg 834841 aagtggccgg ggaatatccg cgagctgttt aatgtgtttg aacgtctttc tatcagattt 834901 ccggacggcc ggctgagaga tgaatcgctt cccgctttac tggaagccgc tggattgccg 834961 gccagctctg cagaaaaaaa gccggctgct gccggcgtgc ttacttttcg tgagcaaatc 835021 caaaaggata tgatgatcaa agcgcttgaa tctgcaaaag gaaacgtctc tcaagccgca 835081 aaaatcagcg ggatcccccg aagcactttc tacaaacgcc tgaaaaaatt caacttgtcc 835141 gctgaatcat aaagcatact tccttcagga aatggaaacg ttatgtattg aaggagggtg 835201 ttacgatgaa tattcaaagg gcgaaagaaa ttgtagaatc tcccgacatg aagaaagtaa 835261 catataacgg cgttcctatt tacattcagc acgtaaatga agaaactgga acagcaagaa 835321 tttatccgct tgacgaaccg caagaggagc atgaagtgca gctgaacagc ttaaaagagg 835381 attaaacaaa aatggcccgc ttcataagca ggccattttg ttatccgcgc ggcgcaaata 835441 aaataacaca gacaccgatg agacaaatga atgcgccgat ccagtcatac agatcaggtg 835501 ttttccggtc aacaagccat ccccacagga ccgcaagcac gatgaatact ccgccataag 835561 cggcgtatac acggccgaaa gatgggaagg actgaaacgt cggaagaatg ccgtatacaa 835621 tgaggatcag cgccccggcg attccgtagc cagctggctt tgcctctctc agccatagcc 835681 aaaccagata tccgccgcca atttcagcaa gccctgccgc gagaaataaa agaatggtaa 835741 tcagcatcat gagcactcct caatttgcat ttatctttca ttatagagga ggagagcttt 835801 taaagcttcg gatgattctc aaattccttc aaatacgctt ttcgctgaac ctctgtaaat 835861 tggctgatcc aattgttttg agcctcttca ttcaaatggg gaaggatata gcgttcaacc 835921 gcttcgaaaa acagcggatt cgtgatgatg ttccaggtcg ggattcgaac gattttgccg 835981 tctgttttct cgatgataat atcctcaaaa aagatccctt tcaaactgta ttgatggcgt 836041 cccatataaa gccgcttcac ctcggaaaac agcacgctgc gctttctcaa gaagatttcg 836101 ccactaggtc cggtctttat ggtgaaaatg acatttccac ggcttgtgaa cgcaggaaaa 836161 gccataaaga atgtgatcaa tccataaatc atcgccagta atccgccgcc caaataaagc 836221 agggcatatt tagattcaaa cgtgagggct tcagacacca gccagactcc cacaataaag 836281 gcgccccctg tagcgaggaa cagccaagcc cttagaaaca tcatgctttt tacttcaatc 836341 atgtgctgcc cctaaagctt cggatgattc tcaaattcct tcaaatacgc actgcgttgg 836401 atgtctgtaa actgtccgat ccaattgctt ttcgcctctt cattcagatg tggaaggata 836461 tagcgttcaa ccgcttcgaa aaacaacgga ttcggaatga tgttccaagt gggaatgcga 836521 atggtcttct gatccacggt ttggatcaat atatcttctt ggaagattcc ttttagacta 836581 aatttatggc ggctcatctc aattttcttg atatcagtaa acgtaacaga cactttgtca 836641 gtgaacactt ctccattttt tcctgtcttg atgcggaaaa tggtatttcc ccgcggggtg 836701 aaagccggaa agaagatgat aaataaatat aaacaaaaca aggtgaacag aaagccagca 836761 ggaatggcta ataggtaata tttcgtttga aacgtaatac ccatataaaa gagccacaaa 836821 catgctaatc ccataccggc agatccgaca aaagcccata ttctcaggaa cattttgctt 836881 ttgacttcaa tgatttcttg gtttttcaat gcttttctcc ttttgttaat tcaattctta 836941 tcattttgaa atgatttgat ttacaacatc cttatgagca gggaggatag aaaattcatt 837001 ctgggtgatg cctgtgacaa gccaagtatg gtgggccccc ggcaggacga atgccatgtc 837061 agccacttca ggagtgttat cttttccata tgccagacgc ataagtgtat ccattttccc 837121 tttccgcaaa gccagatcat ttgcaaatcg ggtaacgtcc tcttggtggt catgtttttc 837181 aaggaactct tttagatatg aagggttgtc tgaagcgccc tccaagagtt tttcaaattc 837241 atttgatgtc aatgttacaa tcgattctct tttatcctct gtatctatta tatgtaaaaa 837301 ctcatctgtc ttagcaagta acccttcact tgattccatt tttgtaatgc gatggacttg 837361 ttcatcaaaa aggagttcgt gagagtaggt gccgaatttt gatacatggc atgacacatt 837421 ctgttcggca ccttgcccgt taaatttaga aagcttcact gtatagtcag cgtcgtttaa 837481 tacatggata aacggacagt actcgtcctt taaccgatat tgatggttcc gatattccgc 837541 tgcatccttg gctaagagtg agcggcacgc ggcttcaaat aaggcgccga gctgttcatc 837601 ttctatttcc ggaaaatagg cctgcttcaa ggccattccc tgttcaaaaa acccttcgct 837661 gtaaaagcaa aacaagagtt cttctatgct aattgtaaac tgcttcattg tttattctcc 837721 tatccaaatg aaaatttccc tttaaggaaa tgggttgcgc cgtgtataag cgaatccgct 837781 gttttctttg ctttttccat tccttttttc gcgctgtcta tccctttatg tatcgattta 837841 ttcgccgcat ctatgccgtc attcactgat ttgacgactt tgccggctga ttccagccct 837901 tttttggctg tatcaacaac agcatggatc ggttctttca gctttaaggc tgctttttca 837961 gcaaaaccgg ctgtatattt ggcgatttgt tctccgacga ctccgccaat gtatgaacct 838021 gctgccccaa gaaggacagt acccacaggt cctgcaaagc ttccgattgc accgccgatg 838081 acagcaccag ctgtggcacc gccggcaaca aaaatcgtat tattcacagc attcccgacg 838141 gccttggcgt tttcacgctt gagaacttcc ggtttatcct ggtattttgc ataattttca 838201 gcaattttca cgcctgctcc gaatgtttcg gtcgctccgg taatcagtgt ggcggtaatg 838261 gcatttcctt tcgcgaatct caagcccgtt tttcccacat ccttcaaagt ggagcgtacg 838321 ccggcttcat taagaaatcc ttttgtgtag cttctgacgc tgtttgaaaa atccaccgtg 838381 tcctgaggaa agtattttgt aaacttttta tgtaccaaat ctgaaaatgg acggtttgtc 838441 tttttcaaca aatatttagg attcaaaagc actcttgccg ctttttgata acgtgagctg 838501 tcaacggccc tggaaatatc caagagcagt tttgagtgct gggctgtatg caagccgctt 838561 ggttgtttca caaatttcgt aagccctaat ccgtaatatt ttccctgcgt cagcataaga 838621 gcggttaagc ttgtcatcgt accgtatttg tcgtaggcat tgtagagctt tcgcaaaata 838681 tcatcttgtt ccacaaattt atcgcctgtt tttctgatga aaatctcatt gtcactcagc 838741 ttagtgacga gcgcctttcc tgagctccac gcatcgccca ctccagaaaa acagctgctg 838801 tagcggggat cgcattgcaa aatcatctgc cccagctcca catgcaggtc cttatatttg 838861 ttttccatat cagttaattc agtgactaca tcatttgcaa gctgttcgag cttatccgga 838921 tcaactgcaa tgtttcctga cacaccgttc acctcccgag tttatgtctt tcctctcttg 838981 ctttacgctc cagttcttcc attctggcaa tttcagcttt tcgttcttct attttgacag 839041 cggcagcctt cagctcttgg cttgtttcaa gcagctcctg ttcgaattga tcgtaggcgg 839101 ctttcgtttc ctcgaaatcc tggtcaaacg aatctcttgc tttgccctgc caagcatctc 839161 ccaatgcaga taaccgggat tcaagcagca ttttggagct tctgacctct tctgcggccg 839221 cactatactt gtttgccagc tcaatgactt tatatgagtc caacttttgt cccctgcctt 839281 ttctaaattc acgcacaatt ggatgtttta tataaatgat tataaataat tcggcatgta 839341 tccgaatcgt acaaaagaac cttttcataa gaattggaag ggcgtatatt cacttaaaat 839401 tcacagttgg tgagacttta agattacaaa aaaggtaaaa aaaccaaatc tctcagacat 839461 aaggcaaatg agaaatttcc cgctctatgg gaaaaaacac taaagttgat caaatgacct 839521 aagtgcgcca aacgtgttac gggacgagct atctcatggt ataaatggaa ttgtaaacgt 839581 tatcaaggag gtcgtcatat gaagaaaaaa tcattctcaa tcgtaatagc gggcggaggg 839641 agcactttca ctccagggat cgtactcatg ctcttggacc atttggagga gtttccgatc 839701 agaaagctga agctgtatga taatgataag gagagacagg atcgaattgc aggcgcctgt 839761 gacgttttta tcagagaaaa agcgccggat attgaatttg cagcgacgac tgacccggaa 839821 gaagctttta cagatgtcga ttttgttatg gcgcacatca gagtagggaa atacgcgatg 839881 cgcgcgcttg atgagcaaat tccgttaaag tacggagttg tcggccagga gacgtgcggg 839941 ccgggcggga tcgcatacgg tatgcgttcg atcggcggtg tgcttgaaat attagattac 840001 atggaaaaat actcgcctga tgcgtggatg ctcaattatt ccaatccggc ggcaattgtg 840061 gctgaagcta cgagacgcct tagaccgaat tctaaaattc tcaatatctg tgatatgccg 840121 gttgggatcg aagaccggat ggcgcaaatt cttggcttat cctcaagaaa agaaatgaag 840181 gtccgctatt acggattgaa tcatttcggc tggtggacat cgattcagga tcaagagggc 840241 aacgatttaa tgccgaagct gaaggaacat gtatcccaat acggttatat tccgaaaaca 840301 gaggctgaag ctgtggaggc aagctggaat gacacgttcg ccaaagcgcg tgacgtgcag 840361 gctgcagatc ctgacacact gccgaatacg tatttgcaat attatttgtt cccagatgat 840421 atggtgaaaa aatcaaatcc gaatcatacg cgggcgaatg aagtcatgga agggcgcgaa 840481 gcttttattt tcagccaatg tgacatgatc acacgtgaac agtcctcgga aaacagcgaa 840541 attaaaatcg atgaccacgc atcgtatatc gttgatcttg cccgggcgat tgcctacaac 840601 acaggtgaaa gaatgctgtt gattgttgaa aataacggtg caattgcgaa ctttgacccg 840661 actgcgatgg ttgaggtgcc atgcatcgtc ggctcaaatg gacctgaacc gattaccgtt 840721 ggcaccattc cgcaattcca gaaagggctc atggagcagc aggtatccgt tgagaagctg 840781 actgttgaag cgtgggcaga gaaatcgttc caaaagctgt ggcaggcgct gatcctgtca 840841 aaaacagtgc cgaacgcgcg tgtggcaaga ctcattcttg aggatttagt ggaggccaac 840901 aaagacttct ggcctgagct tgatcaaagc ccaacccgca tatcataaat gaaattcccc 840961 cattttcgaa tctgtaattg tatataatag aaagaaaatg gggggatctg atatgcagct 841021 cgaagaactg atcaatcagc actacagcaa attgaatgac aacgattttc atattttaaa 841081 atatatattg aatcataagc acacatgcta tcaccttgga atcgacgcgc tggccaaagc 841141 ttgcagtgta tcgcgttcct caattttacg gcttgcccaa aagctcggtt tcagcggtta 841201 cagtgaattt cgcgtctttt taaagtggga agatcagccg gaagaaggcg agagtatgag 841261 ttttgaaaag ctgcttgatg atattgaagc aaatttgaag tttttacgga caaaggacat 841321 gacggacatg tgccagctga ttgatgcagc tgaccgcatt ttcgtctacg gttctggaaa 841381 tgcgcaaaag atatgcgccc gcgacctgca aagaatgttt attccgcgcc atcgctatct 841441 tattttgatt gaagacacaa atgaatttaa tttgatgcgc gatgatttta aagtgaacga 841501 tctgtttatc atcatttctc tttccggaga aacaccggag ctgattcctc aggcaagaat 841561 gctttctgca aagggtattc cctttatttc cattacgaat ttaaaaaaca atgtcctcgc 841621 ccagctgact ccgcataatc tttatgcgac aagcaaacct gtgacattaa gcgatagaac 841681 ggaaattgtc gcttttgcac cgttttttct cgttggcgaa gcattgttcc gcgcatatgt 841741 tgattacaaa gaggcagaaa aaaatgacaa tgagtagcag ggggttctgg tatgatgcaa 841801 aaaattcagc gctttggaag cgcgatgttt gtgcctgttt tattattcgc gttcgccggc 841861 attatcgtcg gtatcagcac gctctttaaa aataaaaccc tcatgggacc gctcgccgat 841921 cctgacggtt tttggtatca gtgctggtat atcattgagc agggcggctg gactgttttt 841981 aaccaaatgc cgctcttatt cgccattggc atcccggttg ctttggcgaa gaaagctcag 842041 gcacgcgcct gtttggaagc gcttactgtc tacctgacat tcaactattt tgtcagcgcg 842101 atattgacgg tatggggagg agcatttggc gtcgacatga atcaagaggt cggcggaacg 842161 agcgggttaa cgatgattgc gggcataaaa acgctcgata ccaacatcat cggagccatc 842221 tttatttctt cgattgtcgt ctttttgcat aatcgctatt ttgataaaaa actgcccgat 842281 tttctcggca tctttcaagg ctcaacatat atcgtgatga tttccttctt tattatgatc 842341 ccaattgcgt tggctgtgtc ttatatttgg ccgatggttc aatcgggaat cggctcgctt 842401 caaagcttcc tggttgcttc tggggcggtg ggcgtttgga tatacacgtt tttggaacgg 842461 attttaattc cgaccggcct tcatcacttt atttacacgc cgtttattta tggcccggct 842521 gtagcggaag gcgggatcgt cacgtattgg gcacagcatc tcggcgaata ttcgcaaagc 842581 gccaaaccgc tgaaggagct ctttccgcaa ggcggattcg cgcttcacgg caactcgaaa 842641 atcttcggta ttccgggtat cgccctggct ttttatgtga cagccaaaaa ggaaaagaaa 842701 aaactcgtcg cagggctgct gattcctgtc acactgacag cgattgtcgc cggtattaca 842761 gagccgattg agtttacgtt cttattcatt tcacctttct tatttgcggt tcacgccgtg 842821 cttgccgcca caatgtcgac agttatgtat atggccggcg tcgtcggaaa tatgggaggc 842881 ggactgattg aggcggtaac cttgaactgg attccgctct ttggcagcca cggtatgaca 842941 tatgtgtatc aaattttgat cgggctctcg tttacagcaa tttatttttt cgtcttcaga 843001 tttttaatcc tcaaattcaa tatcgctaca ccaggacggg aaaaggatga acagcaggaa 843061 acaaagctat attcgaaaaa ggaatacaga gaacgaaaaa acaaggatga aacggcctcc 843121 gctgctgaaa cggctgatga caccgctttt ctgtatattg aagcgctggg cggaaaagac 843181 aacatcactg aagtcacaaa ctgcgccacc cgcctcagag tcagtgtcaa ggatgaaaca 843241 aaggttgaac ccgacagcgt attccgcgcg cttggcgcac acggcgttgt caggaacggg 843301 aaggcgtttc aggtaattat cggattaagc gtgccgcaga tgcgggagcg tgtggaaaaa 843361 atattgaatc aataaagact gccctccttt tcgggagggt tttcgtttgc cgtcaaaaag 843421 accgccatag taaagtaaag aaagagacaa tcgagtaaaa aggggtttgg aggcttttac 843481 atgcaaaagg ctttgtcgtt tttaaaacca tattcattgc tggcgggaat tgctctgatt 843541 cttatgctga cggagcttgc agttgaactg atgcagcctt tattgattgc aaaaatcatc 843601 gacgatggga tattgaagca agatctgcgg catgtatgga tatggggcac ggtcatgatc 843661 gggctgaccg tgttatcctt tgcggcgggg atgctgaatt ccttttatgc cgcccatgtc 843721 agccaaagct tttcctatga tacgagaaaa gggctttttc aaaaaatcca gtccttctcc 843781 tattccacat ttggacagtt ttcgtcctct tcttatatta caaggctgac aaacgacgtc 843841 acacaggttc aaaatatgat ttttatgagt ttgcggttta tgctgcgggc tcccttaatg 843901 attgcaggcg gcattgtgct gtcgcttgcc gttaatgtga aactcgggtt ttttctgctt 843961 gtgaccattc cgatcctgat cttgtttttg ctatgggtat taaggaaagg cggggcactg 844021 ttccgctcag tgcagaaaag gctggatcaa gtgaacacca tcatgcagga aaatttaatt 844081 gcaatcaagc tgatcaaagc gctgcttcgc ggcagccacg aagtcaaacg atttatcaaa 844141 gccaacacaa ggctgatgga aaaaacggtt tcggcctttc agcttgtgga attcacgatg 844201 cctgtactga tgctgctgat gaatctctgc atccttttga ttttgtgggc ggggtcctac 844261 agtattacga gcggaagcac tcaggttggc gatgttgttg cgataattaa ctacgcaaca 844321 cgaattacag gcgcgctttc gatgtttccg tttttgatta tgattttcac ccgggcgaag 844381 gcttcagggg atagaatcgg tgaggtgctt gaaacagaag gcgacgagcg ggaggaaggc 844441 accatatctg atcgtttgtc aggacggatt gagtttcagc atgtatcctt tcgctatcct 844501 gaaatggaca gagaagcgct caggaatgtc tcattttccg caaagccaag agaaacgatc 844561 gcgattctcg gtgcgacggg ctcgggcaag tccacgcttt ttcagctcat tccgcggctt 844621 tatcagccgg attcaggccg catttacata gatgaaaagc cggttcaaga tattccggct 844681 gaagggctgc gcaggcaaat tggatatgta ccgcaggaag tcctcttgtt ttccggcaca 844741 atcaaagaaa acatcgcttg gggcaaagaa aatgcttcac tagatgaaat aatggatgcg 844801 gcaaaacttg cgcaaattca tgaaacgatt ttaaagctcc caaatggata tgacactgtt 844861 ttggggcaaa gaggcgtcaa cctgtccggc ggccaaaagc agcggatttc cattgcgcgg 844921 gcgctgattc gaaaaccggc tatccttcta ttagatgaca gcacaagcgc gcttgatctg 844981 caaacggagg cgaagctgct tgaagcaatc agcacatacc attgcacaac tttgatcatt 845041 acacaaaaaa taaccacggc gatgaaagct gatcagattt tgctgcttga ggacggcgaa 845101 ctgattgaaa aaggcactca cagtgagctg ctttctgaat ctcagttata caagcgcatt 845161 tacgagtcac aattcggaag ggaggggagc gagtcatgct aaaagacatc cgcaagcctt 845221 tccaatatcc caaactgcca attgacaaaa aagaaggcgc gaaaaagcgg gcgaaagcaa 845281 aggatacaaa gggcacactg agacgaatct ggtcttactt ggctgaaaga aaaggactgc 845341 tcatacttgt catgctaatg gttgtcatca gcgccatatt cggactcctt ggtccctttg 845401 tgatcggaaa ggccatcgac cattttatcg tcgggaaaac ggtcagcggc ttgattcctg 845461 ttttgcttct tctgctcgct atctatatca ttcagtccct gtcgctttgg tttcaaaact 845521 attggatgat tacgatctcg cagggcacgg ttttcagaat gagaagcgaa ttgttcaccc 845581 atctgcatga gctgccgatt ccattttttg ataaacagcg gcacggcgag ctgatgagcc 845641 gggtgacgaa tgacatcgaa aatgtcagtt ctaccttaaa cacgtcagtc attcaaattt 845701 tgtcaagtgt gatcaccttt gtcgggacga ttgcggtgat gctgtacatg agcccgctcc 845761 ttactttgat tacgctgacc attattccgg tgatggcagc gagcctgaaa tggatcacca 845821 accgaacggg aaagctgttt aaagaacagc agaaaaacct tggtgatctg aatgggtata 845881 ttgaggaatc tgtttcaggc gcaaaggtca tcaaagcata ttcacgtgag aagcagatta 845941 ctgctgaatt cctcgaaaaa aacgctgcac tcaagacgtc gggcttttgg gcgcagacga 846001 tttccgggtt tattccgaag gtcatgaact ctttgaataa cttaagcttt acaatgattg 846061 cggcaatcgg cggtttgttt gcgctgaaag gctggatctc gatcggctcc atcgttgtct 846121 ttgccgagta ttcaagacaa tttacacgcc ctttaaacga tctggccaac cagtttaata 846181 cgatgctgtc cgcaatcgcc ggcgctgaac gggtgtttga cgtgcttgat gaaaaagaag 846241 agcgcgagga tgaaaagaac gccgtgcatc agcccatcca aacaggcagc attgaattcc 846301 gggatgtgtc cttcggttac gataaagggc agcagacact gaagcattta cagtttaccg 846361 tgcctgcggg gcagtccatc gcgtttgtag gaccgacggg ggcggggaag acaaccgtca 846421 ctaaccttct cgcccgtttt tacgagccta acgatggaaa aattttaatc gatggtacag 846481 atattaaaac ccttactaga gcaagcctaa gaaaaaacat ggggtttgtt cttcaggatt 846541 ctttcttatt tcagggaacg atcagagaaa acattcgcta cggcaggctt gatgcttctg 846601 atcaggaagt cgaagccgct gcaaaaacag cgaatgccca tagttttatt gaaaggctgc 846661 caaaagggta tgacaccgta ctgacgcaaa acggttcggg catcagtcaa gggcagaagc 846721 agttgatttc tatagcgagg gcggtgcttg ccgatccggt tcttctcatt ttggatgaag 846781 cgacaagcaa cattgatacc gttacagaag tcaacattca agaagcgctc gcccgtttaa 846841 tggaaggaag aacaagcgtc atcattgccc acaggctgaa caccattcaa agagcggacc 846901 agattgtggt gctaaaaaac ggtgaaatga ttgaaaaagg cagccatgac gagctgattc 846961 ggcaaaaagg attttacagt gacttatatg aaagccaatt tgagaaatag acctttgtcc 847021 tgcacagagg tctttttttg ttacagtttt atagtacttt tatttcattt tcgtaaaatg 847081 taacaaaatt acttgacgta aacaagttat gtatatatac tagcttacat taagtaagtg 847141 ataacattta tcaaggagga taaaatgaat aaatcatttg aaattggcac attactttta 847201 agagttatta caggtattat cttttttgtt cacggtttat caaagtttca gggaatggag 847261 ggcaccatcc aatttttcgg cagcataggc cttccaagct ttatggcgta tgtcatcgca 847321 gcgattgaac tgattggcgg agtgcttgtc ttcttcggat tggctacacg tattgtcggt 847381 gtactgttcg ctcttacact gatcggcgcc atcatcactg ttaagctgaa agcgccattc 847441 atgggcaatg cagaatttga ttaccttctg cttttgacat ccattcacct ggcgcttact 847501 ggaagtcgat tcctggcgct ggacccattt gtgtttaaag gaaaaaagaa cggaaacgtt 847561 tcagcataag aaaagaggca tgcagcatga ccagcattca tgaggataca cacattggct 847621 atgccaaact cacaattcgc agtctggagc gttcgcttca gttctactgt aacgtcatcg 847681 gttttcaagt cttaaaaaag acggaccgcc aagcggaatt aacggctgac gggaaacgcg 847741 tactgcttat tcttgaagaa aatccgagcg ctgtcgtctt gcctgaacgg tctgtgacag 847801 gcctttatca ctttgcgatt cttcttccgg acaggaaaga acttgggatc gcgctcgccc 847861 gcctgattga acacggcatt gctatcggac atggagacca tgctgtcagc gaagcgctct 847921 acctgtctga tcctgacgga aacggcattg aaatgtacgc tgaccgcccc cgcagcacgt 847981 ggcagcgtga tcgggaagga aactacgtca tgacgacaac cgctgttgac attgagggcc 848041 ttctggaaga ggcaggagat gagcggaaaa catcgcttcc gaacgataca atcatcggac 848101 acattcatct gcatgtcagt gatttgaaag aagcaaaggc gttttataca gatgtactgg 848161 gctttgacat tgtcggaaac tatgcgggca tgtccgccct cttcgtttca gccggggggt 848221 accaccatca tatcggctta aacatttggg cgggaagaaa tgcgccgcct aaaccgacaa 848281 atgccagcgg actagattat tatactgttg tcctgcccca ccaagaggag ctggatttgg 848341 tggcaaaccg agtcaaacat gccgggtatt cgattgaaga gacggaaaac agctttcgtg 848401 tgaaagaccc tgtttccggc gcctatatta catttgtgat ttaactgcaa tccccttgcc 848461 gaaataacgg cagggggatt ttttattttt gtccgccttg ttatgatgag agaaccaact 848521 tgttaggagg cgtttacatg gaactcaacc accttgtgac gggcaaaata gcattaaatc 848581 aatatgtgca tcgcttagag caaaaggatg tttcatttta cgtccactac tggggagcga 848641 tgacgaacca ctataacaca ctgcttcata agcattcctt ttatgaaatt tgttacgtgg 848701 taagaggtga aggatattac cttgaaggcg atcgtacata tccgcttcgt gaacagacga 848761 tttttttgtc aaagccggag catttgcacc aaatcaaaag tgaaacaggg ctgttccttt 848821 tttacgtcgc tttcgagctg agcgaggatc agtcaagcgc cgaatggatc aaagtgatgg 848881 aagaagtgaa acaaagcccc tttatcacaa tgcaattgaa agatggcgaa ccgccgggcc 848941 tgctttggaa aacgttaatg ctgcaagcag cgcaacctgt caatgctttt gacaaagaga 849001 tcctatctca tttgtcgcat gcattgatcc tgtcattaat ccaaaccttt ctcccgtacg 849061 cccaacgccc gaaacaaaag cagcccattc acacatcttc tgctttgctg acagaggtga 849121 aactgcacat aaaagacaat ctgtcacagc cgttaaagct gacggatgtc gctagccact 849181 ttcatatctc agggaggcat ttatcacgtt tatttgcagc agaactgggc gtcagctact 849241 cagaatttgt ccaaaatgaa aaaataaaca aagctgccga actgctgaaa tcaacgaatt 849301 tgtcgattaa agaaatagcg gaagaaatcg gtttctcagt acattatttc actcgcgtct 849361 tttccgctaa aatcggcagc tctccagggc ttttccgctc cctttataaa gactcaaaaa 849421 tgaccgcatt tcaaatcaat aaaccttttc aaaaaatcga acaggccaag ccgcacgaat 849481 aagatgtcct gaaatgacaa aacaatgtct tcatatgata aagacgcgag aaatctcgtt 849541 gtcttataat ctttttagaa agcggttaca acaaggggta ttgctgaagg agggatgcat 849601 tggcttatgc ttggtgtcgg gtgctctgcc attcttgaaa gaaggggaag aaagccgtga 849661 gtacaaaaaa gaaagaggct gtaataggaa aagaaagctt agctcataaa gggcttttac 849721 gaacgattac attggtatct acattcggcg gcctgttgtt cggttatgat acgggtgtca 849781 ttaatggggc acttcctttt atggcaactg caggtcagct gaatcttaca cctgttacag 849841 aaggactggt tgcgagttcc ctgcttctcg gggcagcctt cggggcgatg tttggaggac 849901 gtctgtccga tcggcacggc cgccgaaaaa cgatccttta tttagcctta ctcttcatcg 849961 cagccacact tggctgtacc ttttcaccaa acgcgtccgt gatgattgcc tttcgttttc 850021 tgcttggact ggcggttggc tgcgcttctg taacggttcc aaccttttta gcggaaattt 850081 cgccggcaga acgcagggga cgaatcgtga cacaaaatga actgatgatc gtaattggcc 850141 agcttctggc atacaccttt aacgccatta ttggcagcac aatgggggag agcgcaaatg 850201 tatggcggta tatgctggtc atcgcgacac ttccggctgt tgtgttatgg ttcggaatgc 850261 tcatcgtgcc tgaaagcccg cgctggctgg cagctaaagg cagaatgggt gacgccctgc 850321 gggtgcttcg gcaaatccgt gaagacagtc aggcacagca ggaaataaaa gaaatcaaac 850381 atgcgattga gggcacagca aaaaaggccg gctttcatga ttttcaagag ccgtggataa 850441 ggcgcattct attcattggg attggaatcg ccatcgtaca gcaaattacc ggtgtcaatt 850501 cgattatgta ctatgggaca gaaattctga gagaagccgg ttttcaaaca gaagctgcat 850561 taatcggcaa tattgcaaac ggtgttattt cagttattgc ggtcattttt gggatatggc 850621 ttctcggcaa agtccgtcgc cggcccatgc tgatcatcgg acagattggc acgatgacag 850681 cccttctgct gatcgggatt ttatccattg tccttgaagg aacacccgcc ctgccgtatg 850741 ttgtgctgag tttgaccatt ttgtttcttg cgtttcagca gactgccatt tctacggtga 850801 cgtggctgat gctctcggaa atctttccta tgcatgtgcg ggggcttggc atggggatca 850861 gcaccttctg cttgtggaca gctaactttc tcattggatt cacctttccc attttgctca 850921 atcatattgg gatgtcggcg acatttttta tctttgtcgc tatgaatatc ctagcgattc 850981 tatttgtgaa aaaatatgtg cctgagacaa aagggcggtc acttgaacag cttgagcatt 851041 cctttcgcca gtatggccgc cgcgctgatc aggaaatcca aaatcaaaca actcacttat 851101 cgtaacctga gataccagga ggaatctatc aatgaaacta tcttatgtaa cagacagcct 851161 agggcatttg ccttttgaag acatgctcaa ttttgccgca aagcttggga tcgatacact 851221 tgaaatgaca accgggggct ggtcgccggc acctcacttg aatcttgatg aattgctgca 851281 aagcagcgaa aaaagaaaag aattttcaca agcgctggaa aagcggaaca tgacactttg 851341 cgcattaaac tgctcgggga accctttaga tccgggtgaa ttgggcaaat cgcacagaga 851401 cataactgac aaaacgatgg agctggctgg attattaggc gtcaaaaaag tgatcatgat 851461 gagcggtttg ccagccggcg gcccggacga caaagtgccg aactggatca catacacagt 851521 aagctggcct cccgttttaa aagatatcct caactatcaa tgggaagacg ttgcgatccc 851581 atattggaag aagcttgtca aaaaagcgga ggcctgcggc gtggggaaaa tagcgcttga 851641 gaacttcagc tctcaattag tctataatcc tgagactctc tttcggctca gaaatgcagt 851701 cggcccgatg gtcggtttga atcttgaccc gagccatttg ttatggatgg gcgcagaccc 851761 gatcatcgca gcaagggagc tcggctcagc cattcaccat gtccatggga aagatgtcag 851821 aattgaaaga tatttatcgg cggtcaacgg acttttagaa acaaaagaag tgacagatcc 851881 tgcaaaccgg gcgtggaatt acgtagctgt cggctgtgga caggatttac agtggtggaa 851941 ggaatttttt tcagttgtaa aaatgatggg atatgaaggt gaggtttctt tagaaatgga 852001 ggatctgacg atgtcacctg aagcgggcat ccgtacttct gtagaagctt taaaacaaac 852061 catcagccaa taggaggttt tcatgatgct aaatggagaa agaatcatct ctaagccgct 852121 tcgctgggca atggtaggcg gcgggcggct cagccaggtt ggatataaac atcgtattgg 852181 agcgctgaga gacaatactg cttttcaatt aactgctggc gcttttgata tcgatgccga 852241 aagaggaaaa gatttcgggg tgaaccttgg agtggatgcg gaacgctgtt atcccaacta 852301 tcaaaccatg tttgccgagg aagcgaaaag acaggatggc atagaggtag tatcgattgc 852361 cactccgaac ggcactcatt atgagatttg taaggcggcg cttgaagcag gagtgcatgt 852421 catctgtgaa aaaccgctgt tcttcacttc agcagagggg caggaaatca aagcgctcgc 852481 agagaaaaaa gggaaaattg tcggcgtgac gtacggtttt tcaggcaatc aaatgcttct 852541 tcaaatgcgt gcgatgattg aacaaggaat gatcggcgat attcgcgtgg ttgacttgca 852601 gtacacacac ggtttttgtg caacagatga aggtgaaaag ataagcgctg cacagaaatg 852661 gcgtgtcgac cctgcgatcg ccgggccaag ctttgtgctg ggcgatttat ctacccacac 852721 gtattatatg tcacagctta ttatgccaaa gatgaaaatt aaggagctgc tgtgtgaccg 852781 acagagcttc gtcggcagcc gcgcaccgct agaggataat gcccatgtgc tgatgcatta 852841 tgaaaatgga gcggtcggaa cgatgtggac atcgtcaatc aatgccggat gtatggatgg 852901 ccatagaatc cggattgtcg gctcaaaggc aagcattgag tggtgggaca gcaagccaaa 852961 tgaactgacg tatgaagtgc agggagagcc gggccagaca ctcgttcgcg gcatgccgta 853021 tttagatgat gtttgcaacg ccgatgaacg actgggcgcc ttacacagcg aagggctgtc 853081 cgaagcatgg gccaatattt atcttaaatt tgccattgcg atagacgcca aaaaccgtga 853141 agatgaagaa atcttgaaca acttggttta tcctgacatt gatgcaggga tcgagggcat 853201 tcgctggatt gagaactgcg tgcgctcggc aaaccaaggg tcagtttggg ttgaatttaa 853261 ataaatgagg gaatgcgccg catatgacat aaagttcata tgcggttttt attttccaga 853321 aactcctgtc aaaaatgccc tgaggcaggt atgataagaa gggaattggg tatcgggagt 853381 gatgagcgtg aaagctcttt tttttacgag aatgttcacc ttgatggtga gctgtttaat 853441 gtatctgtcc attgtgaaag aggataactg gtttggatat gtatttatag cagcaggtgc 853501 tgccatgtat gcagccaatc atgttttgct gacaaaagag acaaatgcca tctggttctg 853561 cctgattgat attgcaatcg gcttttcgtt cggatttatc tttcccggca caggtttgtt 853621 cattattatg ctttgtccgg ttgcggtcgc cttttttctg cgggggtttc ctaaaagaac 853681 agcatggtct gtcttatgtc tttcctctat tttatttttg accgtcctca tccgtacata 853741 tgcgatgttc ggcaatgaat ttgtcattga tcatttgact agcatgacat tcgttgtctt 853801 ctgcggtgtc gtgggcaaat taatccgcaa gctgttggat gcgcaggata cggcaaaaca 853861 gcagtttcag gaactgacgg agtcccatct ggcgctgtct gctgcacatc aggagctcca 853921 tttatatgcg aagcaggttg aagagctgac tgccatttac gagcggaaca gaatggcgcg 853981 tgaaatccat gatacagtgg ggcataaaat gacggccctt ctcgtccagc tgcagctttt 854041 gcgtgaatgg caaaaaagag acagccaaaa agcggatgag acagtaggtg tctgtgaaac 854101 acttgcccgt gaagcgcttg atgatgtccg cttatcagta cgcactctgc aaactgaaaa 854161 cgatccttcg ctaatcgaat cgctgaaaca gctgacagag gacttttgca aaaatgcagg 854221 agtcacaaca gaatttgcgg tcagcggtga tcctgcaatc atcccgctgt ctctccatcc 854281 gaccctgatc agaacggtgc aggaagcact gaccaatgcc aaacggcacg gcggcgccgc 854341 agcctgttcg atacagcttg cctgcacaac ggacagcatc agccttgtca ttaaggatga 854401 cggcaaaggc aatcctgagg cagcacttgg ttttggtctc ttgaatatga aaaagcgggc 854461 agcggagcat ggcggaatga tccgctttga aagcgaacgg gatcaaggat ttactgtaaa 854521 tgcagaattt tcacttgcca ataaaaaatg gagcttcggg cccgtgcagc aaaaggagag 854581 tttatcatga ttaagatcat cattaccgac gatcaggata tcgtcagaga agggctggca 854641 tccctgctcc agctccgaga agagctcgat gtgatcgcaa cggcgcgaaa cggacaggaa 854701 gccttcgaaa aggcgaaaga gctggagccg gatatcgtgt taatggacat ccgcatgccg 854761 gtttccaacg gggtggaggg aacaaaatta atcacaagct cgctgccaag cgtaaaggtt 854821 ttgatgctga caacctttaa ggattcagcg ctgattgctg aagcgcttga agagggagca 854881 agcgggtatc tgctgaagga tatgtctgca gatacgattg taaaagcagt gatgactgtt 854941 cattctggcg gaatggtgct tccgccggaa ttgactgccc aaatgctgaa tgaatggaag 855001 cgtgaaaaac agctgaaagg aataaatgag atagaaaaac ctaacgagct gctcgacctg 855061 accgagcgcg aaatcgaagt tctggctgag ctgggatacg ggctgaataa caaagaaatt 855121 gccgaaaagc tttacattac agaaggcaca gtcaaaaacc acgtttcaaa tattatcagc 855181 aagctggctg tcagggacag aacccaagcc gccatttact cggtcagata tggtgtatct 855241 gtcttttgac atatgacgtt ttgcatatac gcttctctga aaaggccttt tacaggcctt 855301 tttttcatgc cctatgttct atctgccgct acatgccgca cgcctttctt tcttctacaa 855361 tggcaatgga tcaaaaaaag gagtgagacg acgtgctgca agcagaaaac atcaaaaagg 855421 catacggaaa aaaaacaatc gtgaaaggca tttctttttc cctcaaaaag ggggagtcgt 855481 tcggtctgct cgggcctaac ggtgcgggga aatccacaac catctcgatg atttccggcc 855541 ttgtgccgca tgacagcggg aacatcacgg tgggcggcta tgttatcgga aaagaaacgg 855601 ccaaagcgaa acaaaaaatc ggcattgttc cgcaggaaat tgcattatat ccgacgctga 855661 cggctcatga gaatcttatg ttttggggga aaatgtacgg acttacgcac ggtgaggcca 855721 aaaaaagagc ggctgaggtc cttgaatatg tcggtctgac tgagcgggct aaagataaga 855781 ttgaaacatt ttccgggggg atgaaacgaa gaatcaacat cggtgcggct ttaatgcata 855841 agcccgagct gctgattatg gatgaaccga ctgtcggtat tgaccctcaa tcgagaaatc 855901 acattttaga aacggtcaaa cagctcaacg aaacgggcat gacggtgatc tatacgagtc 855961 attacatgga agaagttgag tttttatgcg accggatcgg gataattgat cagggggaaa 856021 tgattgcgat tggcacaaaa actgatttgt gcagccgcct tgggggcgat accatcattc 856081 agctcacggt cagcgggatc aatgaagcgt ttcttgtggc gatccgatct ctggcccatg 856141 tgaatgatgt aacagtacat gaattagagc tcaaaattga catttctgcg gctcatcatg 856201 agaaagtcgt cacaagcctg cttgctgaag ccactgctca tcatataaac ctgctgtctc 856261 ttcaggtgca ggaaccgaat ctggagcgcc tgtttctgaa tctgaccggc cgcacgttgc 856321 gggattgagg agggacggca atgaaaaaaa gcatatggat cgcatggaaa gatgtgaaaa 856381 tcagaatcac ggacagaaaa gggtttatga tgcttatcct aatgccgctc atcctaacct 856441 gtattttagg cgcagcgctc ggatcagttg ttgacggagg cagccggatt gatgatatca 856501 aagtcggcta cattcaatca gaccagtcag atacagcaaa catgtttaca aaagatgttc 856561 tcaaaaaaat gaagtcgata aaggtcacaa aagtcggcag caaagacaag atgaaaaaac 856621 tgattgatga aaagaaaatc gatgtaggca tcgttatccc gaaccattgg gaagccggca 856681 aaacctcagc tgttgttaat gccgctcctg atcaaacatt gaaaagttcc atcattgaaa 856741 cagctgcaag ctcatttata gagcaatata aagcggtaaa ggaagccgcg tcaggctcaa 856801 tggactacat cagtaaaacg gaagctgtaa agcaaggaaa acttgaccct gcacagtttg 856861 cagaaaagct ggcaaagacg ctagaaaaag aaacaggtga caagcttact attgcggaaa 856921 aatctgtcgg cagcaaagcc gttaccagtt ttcaatacta ttcggcggca atgctttgca 856981 tgtttatgct gtttcatatc acagtcgggg cgaaatcatt tttacaggaa aaggatacgg 857041 agacgcttgc cagaatgctg atgacgcctg cgcaaaaatc cgtcattctc ttcggaaaat 857101 ggcttgggac gtatctgttt gccatcatac aatttttcat atttctgatc gtcacaatca 857161 acgtatttgg tgtggactgg ggcggtaatc tgctgttagt gagtgtactc gggctttctt 857221 acgccgcagc tgtatctggt atttcaatgc tgcttgcgtc gtgcatcagc gatatgaaaa 857281 ctgcagatgc gataggcggc ttcggcattc aattgcttgc ggttctcggc gggtccatgc 857341 tgccgctgta ccaatttccg gacgtcttgc agtctgtatc caaagcggtg ccaaatcgct 857401 gggcgcttga cggctttctt tctttaatgg aagggggagg ctgggctgac cttcaaaagc 857461 ctgtgcttct ttttgcggcg atcggctttt gttcacttgt aattggtatc agacggcttc 857521 atacaagata aggaggtaca aaaggtgaaa aaaattctag ccatttgcgg cattgagctt 857581 tctctcattt ttaagaagcc acagaactat ttgatcatgt ttgctgcccc gcttttgctt 857641 acctttgtat ttgggagtat gctcagcggc aatgatgata aggtgcggct tgcaatcgtt 857701 gatcaggacg atacgattct ctcacagcat tatattcggc agctgaaggc acacgatgat 857761 atgtatgtat tcgaaaacat gtctgaaagc aaagcgtcag aaaagctgaa acaaaagaaa 857821 attgccggga tcatcgtcat ttcccgctcg ttccagacac agctggaaaa aggcaaacat 857881 cctgagctga ttttccgtca cggccctgag ctgtcggaag cgccgatggt caaacaatat 857941 gcagaaagcg cattggcaac gctcaatatt caggtgaccg cggcaaaaac ggcatctcag 858001 acagcgggag agaactggaa ggcggcgtat aaaacggttt tcgccaaaaa acatgaagat 858061 atagttccgg ctgtaacacg acagacgctc agtgataaaa aagagggtgc ggaagcaagt 858121 gacacagcct ccagagcagc agggttttcc atcctgtttg tcatgctgac catgatggga 858181 gcggctggaa ccattttaga agcaagaaaa aacggcgtat ggtccagatt gcttacagcc 858241 tctgtcagcc gagccgaaat cggtgctggg tatgtgctgt ccttctttgt cattggctgg 858301 attcaatttg gaatattgct tctttccacc cattggctgt ttggcatcaa ctgggggaat 858361 ccggctgcag ttattgtatt agtgtcactt tttctattga ccgttgtcgg cattggattg 858421 atgattgcgg ccaacgtcag aacgccagaa cagcagcttg cgttcggcaa cttgtttgtc 858481 atcgcaacat gtatggtgag cgggatgtat tggccgatcg acattgaacc gaaatttatg 858541 caatccatcg ctgaatttct tccgcaaaag tgggcgatga gcgggttgac agagattatc 858601 gctaacggtg cccgcgtcac agatattctc ggaatctgcg gcattttgct tgcatttgct 858661 gcgatcactt tcgcagcggg gctgaaagcg ctccgagcct aaaaaacatc tgccgtttag 858721 gcagatgttt ttttgcatgt gggtacattc gtatgggtgc agcctgaact gcggttaatc 858781 cttatctatc atagctaaaa ttgattccag ccaagaaacg taatttttct cccgctccag 858841 cgctttcgtt agcacaagat agtggccgaa gtccggtgaa gaaaatgaca tcggctctgc 858901 tgaagccata agcttttcat agcttccctg taagtcagaa agcttggcct ggcgtttttg 858961 cagctggtct ttgaacaaat cagaagcctc ctggcgcgat agacaagaaa tgaaataagc 859021 cttcagcata aattcatcct tcaccgtctc gggtatcggc tggtggcgga tcagccagtc 859081 atgcagctcc tgctttccgc tgtctgtcag ggtgtacatc tttttctcca gctttgtgcc 859141 ctgaatcgtt gtccggaacg tgataaatcc ttcatccgtc agctttttga gctcagggta 859201 aatctggctg tgcttggcgc tccaaaactg gccgagctcc tctttaaaat aactcgtaat 859261 atcgtatcca ctcaattcgc cttttcgcaa aagccctaat atggcgtatt ttaatactct 859321 catgctatcc tccgtgtctg gctgtttcgc aaaacagatg agccggtgct caactgtgat 859381 tctaactgcc tattcccctt attatagaaa agggaggaag ggaacacaac cgggctcttt 859441 ggaaatgaag ataaaaggtt tgtcagaagg tatccgattt atctccgtca atataaaaga 859501 gatttaaatt taattttcag aaaaaatagt aacgatattg attttttata tataatagga 859561 aattggtggt atgaaaattt tttgggggaa taaacgtgaa aaaagtactt atggcattca 859621 ttatttgttt atcgctgatt ctatctgttt tagccgctcc gccgtctggc gcaaaagctg 859681 agtcagtaca taatcctgtc gttcttgttc atggaataag tggtgcatca tacaactttt 859741 tcgctattaa aaactactta atttctcaag gctggcaaag caacaaactg tacgcaattg 859801 atttttatga taaaacagga aacaacctaa ataacggccc gcagcttgct tcatatgttg 859861 accgtgtttt aaaagagact ggggcaaaaa aagtagatat tgtggctcat agtatgggag 859921 gcgccaatac gctgtactat attaaatatt taggcggggg caataagatt caaaatgtcg 859981 taacgcttgg aggggctaat ggtttagtgt catcaaccgc gctgccgggc acagacccta 860041 atcaaaagat cctctataca tctatttaca gtctcaatga tcaaattgtc atcaatagct 860101 tgtctcggtt acaaggagcg cgaaacatcc agctttatgg catcggtcat attggcttgc 860161 tttctaatag ccaagtgaac ggctatatca aagaagggct gaatggcgga ggcctcaata 860221 caaattaata tcttcaaaaa acaacctgct gtctccgtta cagtgggttt tttcgtctga 860281 gaaagccata gggtcttatg accttagtct atcatgcata cgtcaattta tgacatcagg 860341 cactttttca aatagagcgg acatgttaag gtacaaccat cgatttctat caatttgaaa 860401 taaaaggagc gctgttatgc aaattaaaga aatttttatg atccgctgca tttcgtgctt 860461 aagtgtcgtc ttgctccata tcatttcaat ggtcctgatg cttcaggcag aagctcttgc 860521 agatatttct cacactgttg attctttccg cacactcctg atgttcagca cgcccgcttt 860581 tattttcatc tctgaatttt tactggcccg ttcttatcct gatggggtgc ctgacggttt 860641 tttaaagaag cggggaaaag tgatttttgt tcctttttta tttatcgcag ccatcgatgc 860701 gctgctgatg accagtgcga tggggggaga ggtaaccttt ctcgcgtttg tgcaaaaata 860761 tctggcgaac gtattcttag gaaactttat cggatacttc attctcgtca tctttcaatt 860821 ttacatgctg catatgatgt ttcatgagta tttgaaaaaa gcatcgccga aatgggtgct 860881 gtctatctca tttgtggtga cagccgctta tttaggctat ttctccgcag ccagcccggc 860941 tcctgcttct gaagagggag gggcatttcc gttcttctgg gttccgttcg caggctggct 861001 tttctacttt tgtctagcct actattgcgg aaaagaatac aagcgttttt tagcgctgct 861061 gaaccaatac cgctgggtgg tgtacggcgc cgcaattgct tctggggcgc tggttgtcac 861121 tgtttcttat gtcggtgaaa tcggcatgat cagctcgaag cggcctgata tcatgctgta 861181 ttcaacaagc atgattttcc tgtgttttca tttgttttcc aaaatgaagc atgtgccgaa 861241 aatcatgatg tttatcagca actattcctt ttcgatttat ctgcttcatg cctattttat 861301 gattataggc tacgtgttgc ttttgaatat gcccgaaatt cctgccgtac cggctgttct 861361 cctgttgttt gccgtgtgca cagccggccc gattatgacc tcatgggcgc tgaataagtt 861421 caaatacggg tatttatttg tggggaaaat ttatcagcca aaacagaaga aggtaacagt 861481 cgaagtgcgt gatcacgcag ggtgaaaaac aagcggcagg agggctcctg ccgcgtttct 861541 ttacttctca tccgcttgca gaactgtttt taaatatagt tttgcagact cagcaagtcc 861601 agatacatca gccttttctt catcgaaata cagggcgttt tgaatgatgc cgtcattcat 861661 attgaggaaa aacttggcga tagtcgcaag aggctgaacc ggctgaaact ctccctgatc 861721 gatccctttt tgcaatagcc ttgaaaacct ttccacaaaa agatcatacc ttttctccaa 861781 atactgccgc cgttcttcat tgcgccaagc tgtcactaaa tattcaaatt gcaccggcgc 861841 cagcgtatct gctacatctc gcaggccctc agtcagttca tccaaatagc tggaaatgga 861901 ggcccaaaca ctttggtgtt cagctgattt atcaagcttt cggagtcctt catccagccc 861961 tgtttcaata atgcggcgaa acatctcctc agtgcttgaa aaataaagat agacaccgcc 862021 ccggctgaaa cctgactctt ctacaacatc cttcatcgtc gttaattcga atccttttcg 862081 tttaaaaacc gttttggcag cctctaaaat ctctgcctgc cgtttatcct tgtgctcctt 862141 tgttactttt ggtgacaaga tatcgcctgc tttctgcaat tttcttacct ataagtgtaa 862201 tcaacccaat catgatcagc aagcagccac agacaagaaa agcaagtgat acaccgatcc 862261 attccgccag cacgcccccg cccgccatgc cgaggataga ggcgagggtt gtcgcactct 862321 gaatagcgcc gaacacccta ccgctgtaat cgacaggcac tgttgtttgc acgagaatct 862381 gaaatggaat atggacgagg ccgaaagccg cccccatgat gaaaaaagca aatataaaga 862441 gagtgatgcc ggcaattccc ataccgctta ggaatggcgc acctccagtt gctagtccaa 862501 gaagaagggt tccagctgag aaataaagca aataagaagt gattcgccgt ctgccggtaa 862561 tggccgctgt aaggagcatc ccggctccgc ttacggccat gcaccagcct gccagctcgg 862621 gcggagctcc tgaaaaggag cggataagaa taatcgcttg ggaatcacca atctgcaaaa 862681 caaagagaac gacacaagct gttagtaagc ctgttaatag aagcggcatc cgtttcaaaa 862741 actgaaggcc ttccttgata gaagtaagtg ctgctgtttt ttcttgaggt gtattggctt 862801 tttgtaaaaa agcatctctg ggaaggaaaa acaaaatgac agcggaaaga aagaaggcgc 862861 cggcgtttat ataaaaaaca gagtgtatcg agaaagcagc gatcagcgtg ccgccaaggg 862921 cagggccgaa gatttttgag ctgttatcaa tgatgctgct gacggaaacg gcctgctgaa 862981 tgtgtgcttc cggagccaat tccttaagct ttccgttttt agcaggtaaa aaaagtgaag 863041 aaaaacagct ctgaacggat agcaatacgt aaagctgcca aagctcactg acataaacgc 863101 agctgataac agtgagggca cggccgattt cagatagaaa catgatcgtt tttctgtcaa 863161 aacggtcggc aagcagaccc gatacaggtc cgagtacaat gacaggcaaa gcaaacgaca 863221 tcattaaaag cgacatatct aatggagaag catgaagctg aaaagcggct aatgttagca 863281 cggccaaaat gtgaagccag tctccaagtg aagaaatggt ttgcgaggct aacagtgtca 863341 tcagtccttt ttgattgcga aacaacggtt tttccatgat tcatcctcct gattattaaa 863401 atgacactag tgtcgttttt aattgtatgg gaaaaagaca caatatacaa tctttttctt 863461 gtaaaataaa ggagaagatt gaatagaagg gagaacattc atgacatcag tcaatctaag 863521 ctacccaata ggagaataca agccgaggga atccatatcg aaggagcaaa aagataaatg 863581 gattcaagta cttgaagaag tgccggcaaa attgaagcaa gctgtagagg tcatgacgga 863641 cagccagctt gacacaccgt accgggacgg tggatggacc gttcggcaag ttgttcatca 863701 tctggctgac agtcatatga acagctatat tcgttttaaa ttgagcttga cggaagagac 863761 accggctatc cgtccgtatg atgaaaaagc atggtcggag ctaaaagact cgaaaacggc 863821 agatccgagc ggctcactcg cgcttttgca ggagcttcac ggaagatgga cggctctgct 863881 ccgcaccctg acggatcagc aatttaagcg cggattttat caccctgata caaaggagat 863941 cattaccctg gagaacgcgc tcggcctgta tgtctggcac tcacatcacc atatcgctca 864001 tattacggag ctttccagac ggatggggtg gtcttaacgc ttttgccggc ggaaagccgg 864061 aatactgata gcagcaatca ccagaagtga gaccacagca gccgctgcat ataaatgatc 864121 atagccgctg gcgacactcg catgaatggc gtcgcttatc gcggttttga cttcaggaac 864181 gggaatgcgt tcgatttgtt cttgtaaaga agaaacttca gaactgtcga tctccggaat 864241 catctgcatc gccttttctg aatatccgct gtccgataag cggctgttga tctcatcacc 864301 tatttggtca aacccggctg tgataaaacc tgcataaaga gtaggcgcca aggtcagtcc 864361 aatttgcctt actaatgaaa gcgtgccaag agctgtaccc ttatttgttt ttgccgcttc 864421 tgatacaagg acgttcagcg gagcgcctaa cagaaagcca aaaccgatcc cagctgccac 864481 acttgcgatc acaaactccc atttttccgt gacccagagc ggaaataaag caaaccccgc 864541 acatgagatg attcccgaaa gaataacggt ttttacagga ccttttttgt cggtaagtgc 864601 tccgccaagc caagcgccga ttccggaagc caacgcaagc ggtgtcatcc aatagcctgc 864661 ttttgcggca gggacaccca aatactgttc gacatatgac gggataaaaa tgactgccgc 864721 caagagcccc ccggataaca aaccgatgat aagcgtgcgc tgaaacatat ggtttcgcag 864781 cagagaatac gccaaaatgg gatcgcctcc tcgcatttca actctctttt catacgagat 864841 aagcgctgca aaacagagta tgccaaaaat aatacatcca taaacctccg gattccccaa 864901 gctgtgtaag agatttgccc cgtcaagatt ggtcatgccg tacatcacag ctaaaatcga 864961 cagggacaaa aggaagattc cggccgcatc gaggcgctta gcctcaggtg cttttgtttc 865021 cgcgataaaa catgcgccga aaacaaccaa tagcacggca atcggcaaat taatcaaaaa 865081 tagccaatgc caagacccgg tccaatcaag cagaaagctt ccgatatttg gcccgagcac 865141 agcggccatc ccgttcattg cgccaagcag cccaagcgcc ttcccctgtt tttcctttgg 865201 aagggtcgcg agaatgtgag agctgccgat gatgaaaatc ccgccgcctc caagcgcctg 865261 aatcagccgc gatatcagaa agagcgggaa gctttggctc aaagcaacaa gcaaagaacc 865321 aagtccgaac aggcaaacct caatgagaaa gagttttttt ctgccgtagc ggtcggaaag 865381 ttttccgacg attggcacac tgacgctaag accgagcgta taaagggtaa tgccccatga 865441 tccccaggaa ggggaaacgg aaaacgactc gtttatcgtt gttaaagcag ccgaaataat 865501 tccgttatct aaagcagcca taaacacgcc aatcgtaaac aggctgattg cccacttttg 865561 gcttttctgc tctgttaatg cttcagacat tttcgtcaac tccttttagt tcacttgaaa 865621 tatattattc attttaaatg aactaaatgt caaataaaaa aagcctgctc ccgcagtttg 865681 cggatgacag acttactgat ttattctttt ttcgcattct ctaatgctct tgaaaggata 865741 gacagccctt cgtaaacagc ctgcttttct tcaggggaca gcagctctaa tgaacgcttc 865801 aatttcaggt ggcccttttc atacaaaccc cggaaaatct ttttcgcatt ctctgtcaac 865861 tgaacaacta cagagcggcg gtcctcttca gaatgtgagc gtttgacaaa tcctgatttt 865921 tcaagccggt caagcagccc agttgtattg gacagggaag cccccatttt ttcagcaatg 865981 tcgctcactt tcaatgttcc atggttgttt aatagcatca gcaccttcat ttgcggcatg 866041 ctcatatcca gtttcatcca ctcggacaca tcaccgagcc cggcggacgt taagactttc 866101 atatagagca cccatatttc ccgttcctcc gatgaaagaa tgttttcgtt taagactgtt 866161 gtatcgtgta aattatattc catttcatca cttcctcatc attcactcct cttaccatat 866221 tactcgattt tcactcctga aagaaagtga gcagaaaccg catgcgggac tttgtccgaa 866281 aaataacggt agtgtataat gagttggaga ttattggggg agaggatcga actagaatat 866341 gattggagag accattgctg attaaaaaga atgctttatc aatattaaaa atcgtttttc 866401 ctattgctgt tttgctattt gttatttatc aatcgaaaaa agaactgaca aatctgtcat 866461 tcaaacgtac gctcatggtc atcaacggac tggaacgaac ggatttattc atgcttgtgt 866521 tgatcggctt gctggctgtt gcggctatgt cgctgtatga ttacgtcctg aagtactcac 866581 tgcgcctatc gatcacaaac ggaaaagttt tcagggtttc ctggatcgcc aattcattta 866641 ataatgtgtt gggattcggc ggtttagccg gagtcgggtt aagaatgatg ttctataagg 866701 agcatacgaa agaccataag gcactcgtga aaggaatcgc ctggctcaca tcatctatgc 866761 tgctcggatt atctgttttc agcattttcg ttgctgcgag agtgctgcca gttgatgaag 866821 tgattcatga gaagccttgg ctgtgggcgg tcgttatcgg ttttgcactg atattgccgt 866881 tatctttagc ggtgtccaaa ataaaagacc gcaaagctgg ggacgaagag aatgcggata 866941 aagtgaaaaa tccgattttc gcatatattg gagcttcagt tgttgaatgg ctcatggccg 867001 ggaccgtcat ctattttgct ttgttcgcta tgggcattca tgcagatatc aggtatgtgt 867061 tcggggtgtt cgtcattgcg gcgatcggag gaatgatcag cctcgtgccg ggcggcttcg 867121 gctcgtttga ccttttattt ttgctgggga tggagcagct tggctatcat caagaggcca 867181 tcgttacttc tattgtgttg tacaggctcg cctactcatt tatcccattt atcttgggac 867241 tgttctttgc cgccggcgac ctgacggaaa atacaatgaa gcggctcgaa acgaacccgc 867301 gcatcgcacc ggcaattgag acgacaaacg ttctgcttgt tgttcagcgt gcggtattag 867361 tgagaatttt gcaaggctcg ctttccctta ttgtgttcgt agcaggtctg attgtcttgg 867421 cctcagtttc cttgccgatt gacaggctga cggttatacc gcacattccg cgcccggcgc 867481 ttttgctgtt caacggcctg tccttaagct cagcgctcat tctgctcatt ttgccgatcg 867541 agctttataa acggacaaaa cgttcctaca cgatggccat tacagcgctt gtcggcggct 867601 ttgtgttcag ctttttaaaa gggcttaaca tcagcgcgat attcgtactg ccgatgatta 867661 tcgtattgct tgtgctattg aaaaaacaat ttgtccgcga acaggcatcc tatacactgg 867721 gacaattgat attcgctgtg gcgctgttta ctgtggcgct ctttaactac aatctgatcg 867781 cgggctttat ttgggaccgg atgaagaagg tgctgcgtca cgaatatttc gtccacagca 867841 cctcgcatat tacacatgca accatcatgg cgatcatcat tgtgccgctg ttcttcttga 867901 tatttacagt ggtctatcat aagagaacga aaccgatcgg agagaaagct gaccctgagc 867961 gtcttgctgc gtttctcaat gaaaaaggcg gcaacgcgct gagccatctt ggttttcttg 868021 gagataagcg gttttatttt tctagcgatg gaaatgcact gcttctgttt gggaaaatcg 868081 ccagaaggct ggtcgtgctc ggcgatccat ctggccaaag agaatcattc ccgctcgtgc 868141 tggaagaatt tctgaacgaa gcgcatcaga agggattcag tgttttgttc tatcaaattg 868201 aacgagagga catggcgctg tatcacgatt ttggctacaa cttctttaaa ttgggtgagg 868261 aagcatatgt agatttaaat acatttacct tgactgggaa gaaaaaagcc ggccttcggg 868321 caatcaataa ccgctttgag cgggaggagt atactttcca tgtggatcat cccccatttt 868381 ctgatgcgtt tttggaggag ctgaagcaaa tctcagacga atggctcggc tcgaaaaaag 868441 agaagggatt ctcgctcgga ttttttgatc cttcctattt acagaaagcg ccgatcgcct 868501 atatgaaaaa tgcagaagga gagatcgttg cattcgcaaa tgtcatgccg atgtaccagg 868561 aaggagagat atcggtcgat ctgatgcgct atcgcggcga cgctccaaat ggcattatgg 868621 acgcattgtt tatccgtatg tttttatggg caaaggaaga gggctgtacg tcatttaata 868681 tggggatggc acccttggcc aatgtcggca ctgcctttac atccttctgg tccgaaaggt 868741 ttgccgctgt catttttaat aatgtcagat acatgtacag tttcagcggc ctaagagcct 868801 ttaaagaaaa atataaaccg gagtggcgag ggaaatactt agcgtatcgg aaaaacagat 868861 ctctttctgt caccatgttc ctcgttacac gtctgattgg caaaagcaaa aaagactccg 868921 tctaataaga cggagtcttt ttttatttcg tttttaagaa gtaggtttca atatcatcaa 868981 gcaggtagtt tgcggcttta attccgcctg cggttgtcca tacgacgtca tcgacttcat 869041 gtgcattacc tgacttcacg gccttcaggt ttttccatag tgaactgctt gtccactgat 869101 tggcccattt ttcattttct tttgcattat cggctttata agtgaaataa aacagcacat 869161 cagcatccat atcaggaata gattctttac tgtcggttga gaacgtaaat tggtcctttt 869221 gtttcttaaa cagttccact tgtttttcag ggcgtttgaa gccaagctgg tctaaaataa 869281 tcccaggaaa tgaatcggta taatagattc ttgattcacc ggataaaaag cgtacgactg 869341 aaacggtttt gtttgtctgg tcgcccagct tgttttttaa atcagaaaca cgtttatcaa 869401 aatcggcaat gacttccttg cctttgtccg ccttattcac cgcgttggcg tatagagtca 869461 ggttatcctt ccagttcccg gccaaagatt cagcaaaaac agtcggcgca atcgcattta 869521 actgatcata aattttttcc tggcgcactt tgtttccaat aatcaaatca ggctttaatt 869581 ctgcgatggc ttccacattc ggttccgttt caagaccgac gtttttaaca cctttcatgt 869641 catctttcag atagtcatac cacgggtcgc ccttccatga ctttacggct ccgaccggct 869701 taatgccaag cgctaagagc gcctctgttc cttcattagt taaaacaaca atccgttttg 869761 gattggcggg gatgttgtct gatgtcccca ttgcatgttt gaccgttctt gttttgctgc 869821 ttgacacctc gctgttgctt gaactttctg aactattaca ggcagaaagt accataacgg 869881 ccattaaaaa tacgaatagc atgctgatat gctttttcat ctttttcctc ccaatattga 869941 aattcattat catttagatc ataataagca gtgttaagag tgtcaatccc taattgagga 870001 ttattctcaa aaacaaacat tacatagtaa ataactagga gaattagatc atgatctgca 870061 aaaaggcatc ttcaaaatgg attgtgttag tatgtctgat tttcatttta ctgacggctg 870121 tctgcgcaag cgtcgtgtat ggctatacag gtacgtcatg gagacaggtc tatcaggcgt 870181 ttacttcctt caatggaaca aatgagcatg tcatcatcaa ggatgtcagg cttccgcgcg 870241 ctttggttgc gacagtcgtc ggcgcctcgc ttgcagccgc gggcgctctc atgcaggcgc 870301 tcacaaaaaa tccgcttgcg tcaccgggga ttttcgggat taacgccggt gcaggttttt 870361 ttattgttgc cggatcgttt tttctgcata ttcagtcacc tcaggcatta gtatggagct 870421 cgtttctggg ggcagcattt accgctgcga tcgtctatgc agcaggctcg cttgggaggg 870481 aagggctgac gccaatcaaa ctgacgctgg cgggagctgc catggcagcc atgttttctt 870541 ctctgacaca gggcttgctg tctgtcaacg aactcgagct tgcccaggtg cttttttggc 870601 tgactggctc tgtgcagggc cggagtctgg atctgttgat gacgatgttt ccatatgcag 870661 cggcagcgct ggtaatctgc ttctttctcg gccaaaaaat taatctcctc gttatgggag 870721 aagatgtggc aaaaggactc ggccaaaaaa caggcctgct gaaatttgtg atggcgcttt 870781 gtgttgtcat gcttgcaggg tccgctgtcg ccattgccgg gccgatttct tttatcggca 870841 tcattattcc gcattttgcc cgctttgtcg ttggtaatga ttatcgctgg gttctgccat 870901 tttccgctgt tttgggtgcc attttgcttg tttgcgcgga tatcggtgcg cgatatatca 870961 ttatgcctca ggaagttcct gtcggggtca tgaccgccat catcggaatg cctgtgtttg 871021 tgtacatcgc aagaaggggg gcgaagctat gaaacttcgt tttggcgtta ctgcggctga 871081 aaagaaagca tggatcgtct ttttggtttt actggggtta acagctgctg tactcatcat 871141 aagcgctggt ctcggacaaa ggtttattcc tccctgggat gtagcaaaaa cattctttgg 871201 tgcaggttcc aagctggatg aactgatgat catgtcgttc cgcatgccaa gaattttgac 871261 ggctttatgc gccggtgtct gcttggcagc ggcaggcgcg atattgcagg ggctcgtcag 871321 aaaccctctc gcatctccgg atattatcgg aataacagga ggagcggcgg tagcggtcgt 871381 gcttttaatg atgttcttct cagaccgcag cagttcactt acgatcagtc tgtcatggct 871441 tccagcagcc gcatttatcg gcgcatcggc tgtcgggctc atcgtctatt tactggcata 871501 caaaaatggc gcctccacat ttcggctggt gcttatcgga atcggatttt caatgtcggc 871561 gcaggcgatg actaccctgt tgatgatcaa aggcccgatt taccgagcat cacaagccaa 871621 tgtgtatatc actgggtcag tttatgggtc aaactggcag catgtaaaaa tagctattat 871681 cttatctgtc attctcttat tcatttgttt tgtcgcgcta aaaaatatga atatacaggt 871741 gctgggtgaa gatattgcgg cgggtgcagg aagcgctgtg cagcgaaatc gttttttctt 871801 gctccttttg agtacggctc ttactggttg tgcagtttca gttgccggca caatcggttt 871861 tgtcgggctg atggcgcccc atattgcaag acggcttgtc ggctcatctt atggcgcgct 871921 gctcccagcg tcggcactta ttggagctct gctcgtttta acagctgata tcgtcggcag 871981 aaccttattt gctccggtgg aagtgccggc cggcgtcttt acagcggcta tcggcgcacc 872041 ttattttatt tatttgctct ataaaacaag aaattcttaa tcgttacacc cattttctta 872101 aaaaagaaaa tgggtttttt tgataatgac tgaagattcg taattatttt tgctatactg 872161 acagagacat tgataaagaa agggcggcag atgaatgaaa gaagcagagg tattaaaata 872221 tgaagcattt acaagcagtc ccggcaaagg aaaccccgca ggcgtcgttt tgcagggaga 872281 cgattatacg gaagacgaga tgcagatcat agctgaacgt gccgggtatt cagaaacctc 872341 ctttatccga aaaagcgagt cggccgatct tgaactccgt tactttaccc ctggacacga 872401 aatgaatttg tgcggtcatg cgacagttgc ttctctttac gcattatgtg agaaaggaat 872461 gctggagagc ggtaaaacgt acagcatcca aacgaaagcg ggtatcctgc ctgtgaagat 872521 ttctgaaaaa gatggccgca ttcatatcac gcttgaacag gcctctccgc aattcaaacc 872581 atttacaggc gatcggaaaa aacttgcgga cgcactgggt atcaccgatg aagattttca 872641 tgaagacctt ccgattgtgt ttggcagcac tgggatatgg acagccatcg ttccgcttaa 872701 atcattggag gcttccaaaa aaatggtgcc agataacaaa caatttccgg aagtgttagt 872761 tgatctgcca aaagcttcag tccatccgtt tacctttgaa accgtccatc ccgacagcga 872821 cctgcacggg cgccactttt catccccgta ttcgggaacg attgaagacc ccgtgaccgg 872881 cacagcatcc ggcgtgatgg gggcttatat gaaacattat ggcaatgccg agcagcataa 872941 atttatcatt gaacaagggc aggaaattgg aaaagacgga aaagtggaga tcgaaatgaa 873001 cgaagccggc ggccatgtga aagtgaacat gacaggaaca gccgtttact cagaaacccg 873061 tattcttaaa atctaatacg gatgatggtt tacaaaaaga tgcactttcc gttatcatta 873121 tgaaatgata atcattttca attgcatagg aaggtgagac ggtatgcctc aaaccgaaca 873181 aatacatcag cattcagtac tgagggacat catacgcagc agaagatcga ttcgaaagtt 873241 taaacaagag ccagtacctt cagcagtcat tcttgacatg cttgaaacgg caaaatatgc 873301 gccaaatcac agagtgacag agccatggag atttatttac gtttccagtg agacaggtaa 873361 agcgaacctc attaatacat ttgcagcgtt ctctaagaaa tccaagccgg atatgacaga 873421 ggaaaagctt caaaatttca aaaacacact tgggcgcgtt ccgggatttc tcctcgtcgt 873481 gtttcaggaa gatgaaaacg aaagagcgcg ggacgacgat tttgcggcaa caagctcgtt 873541 gattcaaaat cttcagcttc tcgcttggga aaaaggaatc ggcatggttt ggaaaagcgg 873601 aaaaatcctt tatgacaaag aagtccatca ggcctttggt ttacaggata atgagcgttt 873661 cgccgccatc atacaaacag gttatcctga cgaggcgccg gaagtgaaaa aacgcacacc 873721 gatccgcgac cgattcactg aaatgtaaaa aaccccttgt ctcaaacgga gacaaggggt 873781 ttttcattaa cgagatttct ttttcgctct gttgtcggct gctttcgcac gctcttgcgc 873841 ttcgcggtca tctgcatcag caagctcggt tgaatattct tcgtaaacgc cgtcagtttc 873901 cctttttaag gcatcgggaa cttgtggaag cttttgtttg tttttatcac ggtttttgtg 873961 gatatgattt ctgcccatat caaattcccc ctaaaaagtg atatcaaaca aatatagtat 874021 ttggttttaa ggggctatgt attcctactt ccgcttagca gctttttccg cttttttaaa 874081 ttcgcctgaa taaagaactt cctgcatttt tttcaggttg gcgccttgct ggtgcttctc 874141 cctctttttt tccataaaaa ggacctcctt caaccatgtt attcttaagg ttgacgcttc 874201 ctgctgtttt tatacagtct ttcggtccgc tatcagctgt gagagtgcaa attcaagatc 874261 cgaatatgta aaacgaaatc cagaggttat cgcttttttc ggaagagcgc gctgtccttt 874321 cacaatcaaa agactcattt cacccaatgc ttttgataaa aagaattccg ggacggggag 874381 ccagtgcggg cggtgcttca cccgtgcaat cgtttttccg aattgcttca tgtccacagg 874441 attgggcgcg gtgacattca ttgggcctga gatgccggcg ttttccaccg catatcggat 874501 catctgggcc gcatcctcga catgaatcca tgacagccac tgccttcccg ttccgatcgt 874561 tccgccggcc agaaacttat aggggagaat catgagcggg agagcgcctt tttctccaag 874621 catcacgcca aatctcgcat aaactgtccg gatgcccatc gcttcaatat gctgtccttc 874681 cttttcccac aggtgtgcag tatggctgag aaaatcctca tctgacgttg cagaatcctc 874741 tgtgaaagtt ttctcaaggc ttgtgccgta aatgcccacg gcactggctt ggatcaatgt 874801 cttcggcttc tccttctgtt tctgaataag ccgctgcact tcacgcgtcg cattgatacg 874861 gctggagaga atgtgctgct tcgttttttc tgtccagcgg ccaaaaatcg attttcccgc 874921 aagatttatc cagacatcaa tatgaggaag ttcctgctcc ggtgcggctc cttccgacag 874981 ccattggaca tatgtcatat ttttttgttc agtttccctt gcgtttcttg ataaaatata 875041 aacatggtgt ccctggcggg taagaacgcc tgtcagatgc tggccgagaa aaccggttcc 875101 gcccgtcatt gcgatattca tgaacatctc tcctcatcgt tctaataaat atactttacc 875161 tcattgtaat aaaagaaaac gcgtttcagg cctgagaagg gagattaaga tgccgtttat 875221 tacaaaaata tcaacgcaaa aaaagaatac ggaacgcttc aatatttttc tggatgataa 875281 atacgccttc agcgtggacg cggatgtgct cgtgaaattt gagctcaaga agggaaaaga 875341 actcgatgat cttgacatca ttgagattca atacggcgat gaagtgaaga aaggcttcaa 875401 ccgtgcgctt gactttttat cctatcgaat gcggtcgacg aaagaggtcg aggatcactt 875461 aaagaaaaaa gaaacctcgc cccccgtcat tgcggaagtc atccataggc ttaacgatta 875521 caagtactta aacgaccagg aatttgccgc agcctatgtc agcactcaca aaaaaacaaa 875581 cggaaaaggc cctgatgttt tgttcagaga gctaagagcg aagggaattg atgacgatac 875641 aattaaggag gcgctaagtt ccttttcctt tgaagatcag acaagagaag cggtcaagca 875701 tgttgaaaag cttctcaaaa aagataaaaa gctttcgacg aaagaactca aacagcgcgc 875761 ccagctgcag cttcagcgca agggcttctc atttgatgtt atcagcgcgg cgatggatca 875821 gattgaatat gaaaatgatg aagacacaga gaaagaagcg ctgcgccttc acgcggaaaa 875881 agcgtttaga aaataccgct atgacggctc atatgaaagc gccatgaagg tcaaacaatt 875941 tttattccgc aaaggattct cactcgattt aatcgagcaa ttactgcagg aagaggagta 876001 ctgaaatgga gaaacgatac agtcaaatga caccgcatga actcaatacc gaaatcgcat 876061 tactttctga aaaagcaaga aaagccgaac agcatggaat cataaacgaa ctggcagtgc 876121 tcgaacggaa aattacgatg gcaaaagcat atttgctgaa cccggaagat tactcaccgg 876181 gagaaacata tcgtgtggaa aacactgagg acgagtttac catcagttat ttaaatggcg 876241 ttttcgcatg gggatacagg acctcttccc ctcagcaaga ggaagcgctg ccaatctcag 876301 tattgcaaga aaaagaataa agcgtaacag gaggctgatg atcagcctct ttttgtttgc 876361 agcacattta cacgaattct taaagaaaaa atcattgaat tcacttgaaa aatcttttaa 876421 gatgaaactc gttgtttttt aaaatcaaag gaggcgatga cgttgagtat caaaaaccca 876481 tctgtaaaat ttattatatt tgttcttatg atttgtacat tttcaatcgg ctatacagaa 876541 tacgcggtga tgggtatttt gacgtcgatt gccaatgact ttcatataca ggtttcatcc 876601 gcagggcttc ttgtcacggc ttatgcggca agcgtttgtt tgacagggcc gctcgtcacc 876661 atcatttccg tcaagcttcc gagaaagcct gtgcttcttg ggctgatggc gatatttatc 876721 ctttccaacc tgatgagcgc actggcgccg aattttgcgg tattggccat ttcaagaatt 876781 ttatctgcgt ccattcacgg cgctttcttc gcgattgcca tggtattcgc aagtgaaatg 876841 gttccgccgg aaaagcgtgc tgcagctgct gcttcaatga acggcggact gacagtggct 876901 ctaatgcttg gtgttccatt cggctcttat ctcggagatg tcctgaattg gagagcggtg 876961 ttttccatca ttacggcact tggtgtcatc ggatttttag gccttatggc tgccgtgccg 877021 aacagaaaac caaaagtgat cccaatgctt atgaatgagt ggggtgtttt taaacacaaa 877081 caagtgctgt tttccttcgc gattaccatt ttaggctatt ccggtgtctt tatcgcctac 877141 acctttatcg aacccatttt gaggcattca gccggattca gcacggttgg cattacaggt 877201 gctctctttg cgtatggatt gggaggcgtt gccgggaatt tctttgctgg aaaggtaccg 877261 ctgcctttgc tgactcggac gatgatcggc gtaatgatcg gtttaatcgg tgttctggct 877321 gtatttcctt acatcgccat ttacccggct gcagccattg tggcaacgtt cctattcggg 877381 gcatgcgcat tcggcacgcc gcctcttctg caaacaaagg tcatttcctc atctgagggc 877441 ggcacaacca ttgccgcagc tgtcagcgta tcagcattta accttgccaa tgcccttggt 877501 gcatggatcg gcggaatgat tttaaacgga acaggctctt attcctggct gtttgcagga 877561 ggtgcgctta tgaccgcatg cggacttgtg ctttctacct tcgcacactt atcagaaaag 877621 aagagcgtct acgaatatca agtcaataaa gggtaaaaaa cagctgcagt gtatgcagct 877681 gttcttcttt accgtttgcc tgaggctctc attctttctt gaggatgctg attgatagat 877741 ccgtcagcac gctttgaagc atagtcgtcc tttgctctcg gttcaccctg aaatttgttt 877801 tcgttttcgt aaggaaatcc tttttcttta tttcggacca tgtcatatcc ccctaggttc 877861 gagatcaaaa agttgcgtct tttcagatga agacgtaagg ttagtatatg gagaacacca 877921 cgtaataaag cgttattttt ttcctgaaga aaggagactg cacacatgaa tatgtacatt 877981 gagaaactga ctaatctgct tctggaaaag aacgagatga tcagctatat acaggcaaaa 878041 acgtgggtgg aattgttatg gagcgatttc gaagcaacct acgcaaaagc cggacacgcc 878101 tatcaaggtg aaaaaatgac tgaaaaaatc gtcacacaat ggattgaaaa ctatggcggc 878161 cagctccacc tttttcaaag ctcccgtaac gacgtgaatg attacttaaa tcaaagcaga 878221 ggccttttgc attaaaaacc tgccgttaac gaccggcagg ttttttcatt ttcttaaaat 878281 taccttaaca ggaagaaatc ataaacaaaa catgtttcac cagcctgtca atcagggaat 878341 accacttata tcttgtcaaa atgcgaggag gagctttata tgaaaaagaa acaagtaatg 878401 ctcgctttaa cagctgccgc aggactgggt ttgacagcac ttcattccgc tcccgcagca 878461 aaagctgcgc cccttcacga catatctgtc agcatgccat catccgatac ttacatcata 878521 aaagcaggaa agctgaatgt ccggactgag ccaaatcatg aaggtgatat tctcggcact 878581 gtatcatcag aacaaaaggt aaaagtcgat aggttcgtaa atgccgattg ggctcaaatt 878641 catttcaaag gaaagaaagc atatatttca actcactttt taatgaaaac cgcaagccaa 878701 gcgaaaacaa cgaaacagac agccttctat acaccgacgc ccgaaaacgg aaaagctaag 878761 cagctctcat ctggaacaga ggtgacaata cttgggtggg gattcagtga aaacggcgga 878821 tttgacttca cttgggcgtt cgtggattat ggcggagtta aaggctatat tcacacaaag 878881 gatttacaaa tgcgataaaa aggcaggccg aggcttgtct ttttgcctat gcatgaaaca 878941 tttcttcttt ctgcacgtaa caatgagaaa ggagatgatg atatgacggg tttagtcggc 879001 ggagggctta tgatcattgc gggcatactg atcaaactgt ttcctcccaa atcgatcaac 879061 agtgtgtacg gatacagaac gagacgctca atgtcagatc aaagattatg gaatgaagcg 879121 aaccgttaca gtgcatcatt aatgatcctg tcaggcttgg tgattgcggg aatgggtttg 879181 ctgctgggat caaacttgtt tattcttcag cttatcctgc tgattgccgc ctgtgtcata 879241 acatttatgc taacggagaa aaggctgaaa atcatgacgc acagtcaagg aggagataga 879301 agtggacgga gttaaatgcc agtttgtcaa tacgaacgga atcacgcttc acgttgcagc 879361 cgcaggacgg gaagatggcc cgttaattgt cctgctccat ggatttcctg agttttggta 879421 cggctggaaa aatcaaatca aaccgcttgt tgatgcgggt taccgggtca ttgctcctga 879481 tcagcggggc tacaatctca gtgacaaacc ggaaggaatt gattcgtatc ggattgatac 879541 attaagagat gatatcatcg ggcttattac gcaattcact gatgaaaaag caattgtcat 879601 cggtcatgac tggggaggag ctgtcgcatg gcatttggct tccacacgcc cggaatatct 879661 tgaaaaactg atcgcgatca atatcccgca cccgcacgtc atgaaaaccg taacgccgct 879721 ttatccgccg caatggctga aaagctcgta tatcgcatac ttccagctgc ccgatatacc 879781 ggaggcatca ctaagggaaa atgattatga tacattagac aaagcgattg gattatccga 879841 ccgtcccgcg ctttttacat ccgaggatgt cagcaggtac aaagaagcgt ggaagcagcc 879901 gggcgcgctg acagctatgc tgaactggta cagagccctc agaaaaggaa gcttggcaga 879961 gaaaccctct tacgaaacag taccttaccg aatgatctgg ggaatggaag accgcttttt 880021 gagcagaaag cttgcgaaag agacggaaag gcattgcccg aatggacatc tcatctttgt 880081 tgatgaagct tcccattgga ttaaccacga aaagccagcc atcgtcaatc agctgatttt 880141 ggaatatctt aagaaccaat aagctaaaat ttctctccat ccgtctgtca taatggcaga 880201 ctttttctgt gcgttttttt tcatagtctg ttttaaacat gacaaaataa cattaaaaat 880261 catgaatgtc accataaaat tgtaacaaaa aacaggttta aacgacttta aaaaaaggaa 880321 tagccttact gaagatttgt gtaaaactcc cctaaggcaa tacttaaaaa gaataataaa 880381 aagaaggtgc cttaatgaag caaggattaa tctcgattat tatcccgtct tacaatgaag 880441 ggtataatgt taaactcatt catgaatctt taaaaaagga atttaaaaac attcattatg 880501 actatgaaat attcttcata aacgacggaa gtgttgatga cacgcttcag cagatcaaag 880561 acttggcagc gacgtgcagc cgggtaaaat atatatcttt ttctcgaaac tttggaaaag 880621 aagccgcaat tttggcgggc tttgagcatg ttcagggcga ggcggttatt gtcatggatg 880681 ccgatctgca gcatccgaca tatttgctga aggaatttat caaaggctac gaagaagggt 880741 atgaccaagt cattgcccaa aggaacagaa aaggggacag ctttgtccgc tcactcttat 880801 catctatgta ttacaagttc attaataaag cggtggaagt cgatttgcgt gacggtgtcg 880861 gtgacttcag attgttaagc cgccaagctg tgaatgcact tttgaagctg agcgaaggaa 880921 accgcttctc aaaaggcctt ttttgctgga ttggctttga tcagaaaatt gtattttatg 880981 aaaatgtcga acgaaaaaac ggcacctcca aatggtcgtt cagcagtctg tttaactacg 881041 gaatggacgg cgtcgtttca tttaatcata agccgctgag attatgtttt tatacaggca 881101 ttttcatcct gctgctttcc atcatttata tcattgccac attcgttaaa attctgacta 881161 acggtatttc tgtgcctggg tatttcacca ttatctcagc agtgttattt ctcggcggag 881221 tacagctgtt aagtcttgga ataataggtg aatatatcgg ccgaatctat tatgaaacaa 881281 aaaaacgccc gcattatttg atcaaagagg cgaatatccc gaacaaagac ctgcctgaaa 881341 cgaacgaatt aaaaagcatg cggcgtctga caaaaatgca ctgaaaatac caagcgccat 881401 tggcagtgct ttttttgcgt gtctattatc ttaaaagcaa gactggagaa ttcatatgaa 881461 aagaaaacat atcatgatct atgcggccag tttgctggtg tccgttctgg cacacgcttt 881521 ttttgtgaaa gaatgggcgg aaggcaggta tatgacaggt ccgggtgacg ggcttgcgca 881581 aatgatcgta tttaaaaaat tattatttga ccaatataca cacgggaatt ttttctacaa 881641 ttattcattc ggacttggcg gcggcacatt cagtcagctc ggctattatt tttctgcgtc 881701 ttttcttttt cttgctgtgt ctgccgctgt ttggctgctt caagccgtcc agctgatcgg 881761 agaaacggat acgctttttt gggcagagtc agctgttttt atcagtattt tcaaattgag 881821 cttgatcatc tttacgtccg cttctgtttt tcattatctt cttaagcaca gggcggcatc 881881 gttcacggga gccgtgttat acggcgtctc aattatttat ttccgtcacg aagcgtattg 881941 ggaatttttc accgatacaa tggtttggct tccgctgctt gtgcttggcg cagaaaaaat 882001 tattagagag cggcgtccgg cgtggtttat cgttgcgtgt tcgctgacgt taatcaacaa 882061 tttttacttt gcatacataa accttatatt catcggaatc tatgtgctgt tcagatggct 882121 gatccgtttg gaaccacatg aagagaaaag atggattcaa atcagattat ttctcgtttc 882181 aggcttcatt tcttttggca tcagtgcggc ggcgtttgtg ccggtagtat acggtttttt 882241 aaacaacctg cgccctccat acagccagaa aatagagtgg ctcaatttcg atgataatat 882301 cttattttcg agccggatca tcattgtgcc ggccgctttt ctgctgtttt tgtttattat 882361 ttctttttac aaaaaccgtg tgtttcgtct ctttgccggg ttgagcctgc tgtttattct 882421 gtttcatttc agtccgtatg cggcaagcgt ctttaacggt ttttccgccc cgcaaaaccg 882481 gtttgaatat gttctggcct ttaccattgc gggagcagct gcggctggtt tgtcacagct 882541 gtctgaattg aaacggaaag aactgctccc ggccgcagct gtcgtcctgc ttctttactt 882601 gtatcatatc caaaggtata agctcgatat atggaagcct gcgaatgaaa gtattctatt 882661 gctcttactc atgacaatcg cagccttgtt tgctgcagct tttgcgaaaa aacgggcaaa 882721 aatggctgtg tacggtataa tcattctttc ttcgctgttt gtcgccaact cctatcaaaa 882781 atacgcgctc tcagaaggcg gcgatttgga cagtgtgaca aaagaatatc ttacaagtga 882841 ggaatacaga gggcgggaat catctgagct catcagacgt ttacagaagg aagacgatga 882901 cccgctcatg agaatcgact ggatgaacgg ggtccgcaat aatacgccaa tcatttacgg 882961 atttaatggc ttcagcgcgt attccagcat tttaaacaaa gatctgctgg ccttctattg 883021 gaatgattta agcatcgata tgggcaggga aagcgtcagc cgttacgcgt cattgggaga 883081 cagggcgaat ttatacagcc tgctttacgg caaatattat atgaccgaaa aaacaaacga 883141 agccagcgtc ccgtacggct tcaaaaagca tttagaaaca gagcattatg cagtttatga 883201 gaatcagtac atgcttccat tcgttaaaac agcggatgcc atatacagcg aaagtgagct 883261 ggaccgattg cccgctcttg cgaaagaaca ggcgatgctg aaaggaatta tattaaaaga 883321 tccatcagga aaaacggagc agacaccaaa accgtccaat ttgatcacca agtcggacat 883381 caccgcaaaa caagcccagt atcaaaacgg gctgctaacc gtaactggag aaaacggagg 883441 agagctgatc atcaccccga aacagccatc atccgctccg ggagactact atgtcagctt 883501 ttatttgaaa agcaaagcaa aagacaaagg atttacatta aaggtaaatg attatgtcac 883561 aacaaggaaa tcgaacaaat cgatctataa aaccggagta aataatataa cggtaagagt 883621 gcctaaatca ggccatatct caatcaatct tccgaaagga acctatgagc tgagaaacat 883681 agcgctctat gaagaaaatt accaaacgct gaaaaacgct gtaatgcaaa ataaaacaga 883741 gaaagcagac aaactgaatt ggaacaaaaa tcgactgacc ttttcctatc atctgtcaaa 883801 agaccagtac atcatgcttc cgatcccata tgaaaaaggc tgggagctga agatcaacgg 883861 aaaaacacag aagatcgaaa aagcggatta tgcttttata ggcttcaagg cgcaaaaggg 883921 agacaatcac attgagctga cttactatcc gccatacttc aaaatatcgg cgatcatatc 883981 tctcgtcagt ctgctgcttg ctgtttttta tataagacgt aaaaagcccg gctctatata 884041 gagccgagct ttaatttttt ctgaagtttt tcttcgctga atatccatcc cgtataggat 884101 gaacgaatcg tgagatcatg gccgatatga acaattgcga caaacggata atggcctttg 884161 ctccgataac gcaggtcgat aaatctcacc tcataatgat ctttaaacgt atccacttcc 884221 caccggtata ccggagaaaa ggacagaaac gccgcgatgt tatcatcctg ctttgccgca 884281 tgcattacat cggtttcagg aacaggcacc cgattaaatg tatccagaat cacgacatgt 884341 ccttccatgc ttcttcctac atagaaagca tgtgctgtcg tcactgcgat tcgccattgc 884401 ctgaatttca tcgttggaga aataataatg ctttcgatct catcatgaat catctcatga 884461 agcttccgtt taattctcag ctgcatgatc aggcgcacca agtagtagcc taccaatatg 884521 atatataagc tgagaaacgt gatgccggga ctcccgcctg cataccaaat cgcgatagct 884581 gccagatggc tgataaaaat aaacggatca aacgtattaa tcagcccgag cgcaacccat 884641 tttttcgaaa acggacgaat ggcttgtgtt ccataggcgt tgaatatatc aacaaagaca 884701 tgcagaacga ctgccagcag tgtccacagc cacaggtgca gaaaatcggc ctgaggataa 884761 aataaataca gaatcgccgg gatgatgaca gaccaaaaca aaacggcggg aattgaatgg 884821 gtaaatcctc tgtgattcct tatataaaca gcattgtttt taagctttaa cacagtatca 884881 atatccggag cctgagagcc cgcaagcgtt gcgatcataa cagcgtgagc cattgccgga 884941 tctgatccga caacaggatc aagcgtcgca ataccgccca gtgcgatgcc cataacgaca 885001 tgtgtgcccg tatccatagg tgacctcctt gcagggtgat cctgcacatt cactttgtaa 885061 gaaattcccc attttcatat acccaatttt taaactgatt caatcgttct catatgtttc 885121 cgctttttct ttattactat ttaatgtaac atattatcgt actgtgccct tagtgtacaa 885181 caaaaaacag tctaaagaaa agcggggcgc gaaagactgg ggagaaacac atatgaacgt 885241 acttgaagac aaattaaaac aaaaagacat acagcaattt cgcgatgatt taatctcatg 885301 gtttgaacga gagcagcgcg ttttgccgtg gagagaggac caagatccat ataaggtgtg 885361 ggtatctgaa gtgatgctgc agcaaacgag agtagagaca gtgattcctt actttctccg 885421 gtttgtagaa caattcccga cagtggaagc gctcgctgat gctgatgaag aaaaggtgct 885481 gaaagcatgg gaagggctcg gctattattc gcgagtcaga aacctgcaaa gcgcggtaaa 885541 agaagtgaaa caggaatacg gcggcattgt tcctccagac gagaaagatt ttggcgggtt 885601 aaaaggcgtc ggcccttata caaagggagc ggtgctcagc attgcctaca ataaacccat 885661 tcccgcggtt gacggaaatg tgatgcgtgt catgtccagg attctatcta tttgggatga 885721 tattgccaaa ccaaaaacaa gaacgatctt tgaagacgcc atacgagctt ttatttccaa 885781 agaaaaacca tctgaattta atcagggctt gatggagctt ggagccttga tctgtacgcc 885841 aaaatcaccc tcatgcctgc tttgcccggt tcagcagcat tgctcagcat ttgaagaagg 885901 cactgaacgg gagcttccgg taaaaagcaa aaagaaaaag cccgggatca aaaccatggc 885961 cgcgatcgta ctgactgatg aagacggaca agtgtatatc cacaaacggc cgtctaaagg 886021 tttgctcgcc aacctgtggg aattcccgaa tcttgaaaca caaaaaggga tcaaaactga 886081 gcgtgaacag ctcattgctt tcttagaaaa cgaatatggc atacaagctg atatcagtga 886141 tctgcaaggt gtagtcgagc atgttttcac ccacctggta tggaatattt cagtgttttt 886201 cggtaaagta aaacaagtgt cggataccag caagctgaaa aaagtaacga aagaagagct 886261 cgaacaattt gcgttcccgg tgtcacatca aaaaatctgg aagatggcag gagaagcagc 886321 cgccatctcg gctgctccgt aaaccattct taatcgtaag agacgcgcgt gccgtggctg 886381 tagtccgctt cattgcgctt cattccgccg cgcgcttcaa tttcttgcgt taattcccgg 886441 tattttgatt ggccttcttc gttcaaataa ggcataattt gctgaaaggc atgatgaaaa 886501 taagcgagtt cactgttctt ccaatctttt ttggaaacca tgttcaattc gctcatatca 886561 cgtccgacat acataacaga agaccccctt taaagttctt gccattattg tttgtggaaa 886621 taaaagaact atacgctaca aggagatgag gaaaaatgga acaaaataaa tgtgcactcg 886681 taacaggaag cagccgcggt gtcggaaaag cggccgcgat cagacttgct gagaacggct 886741 ataacatcgt cattaactat gcacgcagca aaaaagcagc attagaaaca gcggaagaaa 886801 tcgaaaagct tggcgttaaa gtgcttgtcg taaaagcaaa cgtaggacag cctgcaaaaa 886861 tcaaagaaat gtttcagcaa attgatgaaa cgttcggcag acttgatgtt tttgtcaata 886921 atgccgcttc aggagtacta agacctgtca tggaattaga agaaacacac tgggactgga 886981 cgatgaacat taatgcgaaa gcattgcttt tctgcgctca ggaagctgcc aagctaatgg 887041 agaagaacgg tggcgggcat attgtcagca ttagttcatt aggctctatc cgctatcttg 887101 aaaactacac cacggtcggt gtatcaaaag cagcgttaga ggctttaacc cgttatcttg 887161 ccgttgagct ttcaccaaaa caaattatcg tcaatgctgt ttcaggcgga gcgatcgaca 887221 cagatgcgct gaagcacttc ccgaatagag aagatctgct tgaggatgcg cgccaaaata 887281 cgccggcggg acgcatggtc gaaattaaag acatggttga tactgtggag tttctagtgt 887341 cttccaaggc tgacatgatc cgcggacaga caattatcgt tgacggcgga cgctcactgc 887401 tcgtttaaaa atttttaaaa aagaggaata gctatacgat cacctgcaca ttctaatgac 887461 cgtggaggtg ataacaatgg ctaactcaaa taacttcagc aaaacaaacg ctcaacaagt 887521 tagaaaacaa aaccaacaat cagctgctgg tcaaggtcaa tttggcactg aatttgctag 887581 cgaaacaaac gctcagcaag tcagaaaaca aaaccagcaa tcagctggac aacaaggtca 887641 attcggcact gaattcgcta gtgaaactga cgcacagcag gtaagacagc aaaaccaatc 887701 tgctgaacaa aacaaacaac aaaacagcta atcactgaaa cagaaaaaag cacttcatct 887761 tcgggtggaa gtgctttttt ctgtttgaaa aacgacaaaa cttgtggaag gtctacagaa 887821 tgagtcaaag ggtttgcttt atggagatcg aaatgattaa aggaggaaat gtttatactt 887881 tcatcaggct gaaggaggaa ccgatgaccg aatttgaaaa gctggtaagt gaacagatga 887941 aaacgatgga taagcttctc gatctccaat cagagctcga ccgctgcaaa caaattgagg 888001 cggaactccg gcatttggaa agggatgcaa ggctgcgtgg gattcaggct gaaattgcgg 888061 taaaacggaa acaccttgcc gatatacagg atatgtttca aaagcagaca gagcaggtca 888121 ttcgttcata tcgcagctca gaaaagccgt cttcctttgt gtagtgcagg aatgtgccat 888181 tccccggccg gaatggctct tttattttca tttttcaatt tgtaacgtta taataggtaa 888241 aagacgttgt cggtaagcaa atttggacat actaactgta gggctttata gaaagtaggg 888301 gagaaatatg ggctatccca aggaaggaga aaccattcaa attcacagct ataagcacaa 888361 cgggctgatt catagaattt ggaatgagac aacaatctta aaaagtacag aaatgtgtgt 888421 catcggagcc aatgaccgga cgatggtaac cgaatcagac ggccggacat ggataaccag 888481 agagcccgca atctgttatt ttcacgcaag acaatggttt aatgtcatcg ggatgctgag 888541 ggaagacggg gttcattatt attgcaacat cagttctccg tttgcctatg atggcgaagc 888601 aattaaatat attgattatg acttagatgt taaggttttt cctgacatga cctacaatat 888661 tctcgatgaa gacgaatatg atgatcatcg gaaagccatg aattatccaa aagaaatcga 888721 cagtatttta agagactact taaatacgct gctccattgg attcaccagc gtcagggacc 888781 gtttgcgccc gagtttgtcg atatgtggta tgaacggtat ttgcgctata caaaataatg 888841 gttacgtaaa aacctgttgc ggggtacaac aggtttttca catgggctca cacacatcat 888901 gataaagaga gagggggaat caaccgtggg ggttatgaaa cgctacatgc aattcgtcaa 888961 accttataag aagcaaattt tcgttacagt gttaatcggg atcgtaaaat tctccattcc 889021 gcttgctctc ccattgcttc tgaagtacgt agttgacgac attattcaag gaggcggcac 889081 ggccagtgac aaaaccacgt cattgttcac gattatggcg atcatgttcg ccttattttt 889141 aattttgcgc ccgcctgttg aatattaccg gcaatatttt gcccagtgga ctgccagcaa 889201 ggtgctttat gatataagag ctaagctgtt tgaccatata caaaaactga gccttcgttt 889261 ttacgcgaat acaagaacag gggaagtcat ttcccgagtg attaatgatg tagaacaaac 889321 aaaggatttc gtcatcacag ggctgatgaa tatatggctc gatatgctga cgattttgat 889381 tgtaatctct atcatgctca cactggacgt taaattaacg ctgatctcta tcgttttatt 889441 cccattatac ggaatatcag tgaagtattt ttacggccgt ttacgaaagc tgacaaggga 889501 gcgctcacag gctcttgctc aagtgcaggg gcatttgcat gaacgcattc aaggcatgcc 889561 tgtcatcaga agctttgcga tagaagatca tgaacaggct caatttaatg agaaaaacgg 889621 tcatttctta gataaagcca tccgccacac gaattggaac gcgaaaacct ttgcggtcgt 889681 taataccatt acagatttgg cgccgctcat cgtcatagcg tgcgccgggt attttgtcat 889741 taatggaccg ctgacagtcg gaacaatggt cgcgtttgtc ggatatattg acagaatgta 889801 caaccctgtt agaaggctga tcaattcctc tacaactttg acacagtcaa tcgcatcaat 889861 ggacagggtg tttgaattta ttgacgagcc ctatgaactc actgacaaac caaatgcgat 889921 aaaggccgat cagattcgcg gaggagtgga gtttcaaaac gtttcgtttc aatatgagaa 889981 ggacaaagaa aatattcttc atgatgtatc cttaaaagta aatagaggag aaactgtagc 890041 tctcgtcggc atgagcggag gaggaaaatc aacgctcgtc agcctgatcc caagatttta 890101 tgatgtaaca agcggcagac tgctgattga tgggacggat attcgcgatt atgaagcaag 890161 aagccttcgc aaccaggttg gtatggtgct tcaagatacc tttttattta gtgaaacgat 890221 tcgggaaaat atcgcgatcg gcaagcctga tgccacactt gaagagataa tcgaagccgc 890281 caaagctgca aatgcccatg aatttatcat gagttttcca gaaggatatg agacccgggt 890341 gggggaacga ggcgttaagc tttcaggcgg acaaaagcag cggatctcaa ttgcgcgggt 890401 attcctgaaa aatccgccgc tcctcatttt agatgaagct acatcagctc tggatttgga 890461 aagtgagcat tacattcaag aagcgatgga caaactggcg aaggatagaa caacttttgt 890521 tgtcgcccac cgtttatcga caatcaccca tgcggataag attgttgtca tggaaaacgg 890581 gacaatcatt gaaatcggaa cccatgatga actcatggac tatgagagcc aatacaagca 890641 cttatttacc attcaaaatt tgaactaaaa catcaatctt atatcctttt aacgaaggat 890701 ataagatttt tttgtatata aaaaaacccg gctgtttaac cgggttactc ttctgtttct 890761 atttcgcagt ctttcggatg atacgtttga aaacttgtga taagtgtttc taaatgttca 890821 agctgctcgc gatattccac ggcgcttgcc ataatattga gcatgttgta atcaataagc 890881 tcctcatccg tattctgctg attttttaaa aatgactttg ttaaaagctg cttataccgg 890941 atgccttctt caaccgcgtc atcatgcggc ttgatttttc cgacaaacct catcaaaatc 891001 cgctcgtgcc agtaaagcag gtaatcaagt tcttcagtca atgtttcctg aaactcttcc 891061 ggcatatgat agatctcgtt ttccagacga tgcagcttct tcaatgtatc aagcgcccga 891121 tttgcagtaa taatggcctg tctgaacagg acaagctttc ttgatttcac ataagtcgtt 891181 ttcttaaagt aacttctttc ttctttatat agaagatatg tctgatcaag cttgatcatt 891241 ttttctttca gtttttcaat atcctctttc aaaatcgaat gctctgtcga ctgccgcatg 891301 gacaatctga tccacttcat aatttcttcg gtgttttcga cggtattatg aatcagcttt 891361 gtttcgtact taggaggcaa aaacacaagg ttgacgataa aggaagaaag cacccctaag 891421 atgactgtgc ttgttctgat cagcgcgaac attaaaaagt cgtcaccggc agattctaat 891481 atcgcaatga ctgttacaag agcaattgaa attgtatgtt caattttaag tttcagcatg 891541 attgtaatga caataactgc tgttaacccg atcataatcg ggctgggtcc gaaaataagg 891601 ccgaacactg tggcaatcac agctccgatg atatttgctt gaacctggtc aataataatg 891661 agaaaagagc ggtaaatcga cggctggatc gcaaatatcg ctgcaattcc agcgaaaatc 891721 ggcgcgggaa gcccgatcca cgaagccaaa taaagggcaa gtgtaatcgc aatcccggtt 891781 ttgaaaatgc gggcaccaag tttcattggt ttgtgcgtgc attcctttct atagtaaatt 891841 gtgtgacata gcaaatgggc taatccttaa aattcccggt tagtttattt gctaaacaat 891901 taagtaatat acagggatcg atacaaatat tcaagctatt tttctagaaa aagaccaaaa 891961 tcttacacgc tgtttgattc cataaaaaaa caggagctca aagctcctgt tcaaggtatt 892021 tgattctagt tttttagatg tttaaatgca tcctcgaccg ctgtaagcgt gtctttaata 892081 tcctgctctg tatgtgctgt ggtaataaac caagcttcat acttagaagg tgctaaatta 892141 attccgcgtt ccagcatcag cttgaaaaac gtagagaatg tttctccgtc actccgttca 892201 gcctgctcgt aattttccac tttctcatca gagaagtata ccgtgagcgc accttttaac 892261 cggttgaccg taatggtgat gccgtgtgtt tctgcgtgct tcaaaatgcc ttcctcaagc 892321 atagcgccaa ggtgatcaag cttttcatac acgccttttt ctttgagcac ttccagacaa 892381 gcgatgcctg ataggatgga agcggggttc cctgccattg ttcctgcctg ataagcaggc 892441 cctagcggag ctacctgctc catgatttct tgtttgccgc cataggcccc aatcggaagt 892501 ccgccgccga taattttccc gagtgctgtt aaatctggtt tcacctgtaa gagatcctgc 892561 gcgccgccat acataaagcg gaaagccgta atgacttcat cgtaaataac gagagcccct 892621 gcattatgtg ttaattcatt tacttgttct aagaagccct ctttcggctc cacgataccg 892681 aagttgccga caatcggttc aacgagaacc gccgcgattt cactgcccca tttttcaaga 892741 gctgctttat agctatcgat atcattaaat ggtactgtga tcacttcgtt tgcaatgctt 892801 ttcggtacac cggctgagtc tggtgtgccg agagtagacg ggccggagcc tgcggcgaca 892861 agcacaaggt ccgaatgccc gtgatagcag cccgcaaatt taatgatttt tgtccggcct 892921 gtatatgcgc gagccacgcg gatggtcgtc ataacggctt ctgtacccga attgacgaat 892981 cttactttgt ccatagcggg aatggcttct ttgagcattt ttgcaaatgt aacctcgtgt 893041 ttcgttggtg ttccatacaa tacaccgttc tctgctgctt ttttaatcgc ttctgtaata 893101 tgcggatggg catgtcctgt aataatcgga ccgtacgccg ctaaataatc gatgtatttg 893161 ttgccgtcca catcccaaaa ataagcgccg cttgctttct ccattgcaac aggagaaccg 893221 ccgccgactg ctttatatga tctagacggg ctgtttacac cgccgacaat gtgctgtaat 893281 gcctcattgt gaagttcaat tgattttgta tgcaagaata aaaacctcct atatctccat 893341 gcgtcctttc tattgtagca tgcttccgaa caagaacaat ggcttcgggc ttcagattca 893401 gctgagatgg ttgtaatctg gacaagaatt ggatacgctt aataaaaaaa catccggagg 893461 taacgtaatg actatagaaa tcggacaaaa agcgcctgat cttgagttaa aaggtgatca 893521 tggggaaaca gtaaaattat cggattataa aggaaagtac atcgtgcttt atttttatcc 893581 aaaggacatg acaccgggat gtacaactga agcatgcgat tttcgggaca gtcacgaaag 893641 cttcgccgaa ctggatgccg tcattatcgg cgtcagcccg gacagccagg aaaaacacgg 893701 aaaatttaaa gagaagcata accttccatt tctgcttctt gttgatgacg agcataagct 893761 ggcggaagca tttgatgtgt ggaagctgaa gaaaaacttc ggaaaagagt atatgggaat 893821 cgagcgttcc acttttttaa ttgataaaga aggccggctc attaaagaat ggagaaaagt 893881 aaaagtaaag gaccatgtag ccgaagcgct tcaaaccctc aaagatatgt ctgaaaagta 893941 aatctctatg agcctatgct tacttttacc ctgatatcaa ttgacaaatt atcgtagaaa 894001 gagttacact aattataaac attacaatgt aagaattttt tttagaagag aggtgcatga 894061 cggatggctg cacatgaact aaaagaagcc ttagaaacgt tgaaggaaac cggagttcgc 894121 attactcctc aacgtcatgc gattctggaa tatctcgtta actctatggc tcatccaaca 894181 gcggacgata tatataaagc tctggaaggg aaatttccta acatgagcgt agcgacggta 894241 tataacaatt tgcgtgtgtt ccgggaatca ggtttggtaa aagagctcac atacggtgat 894301 gcttccagca gattcgattt tgtcacatcc gatcactatc acgcgatttg cgaaaactgc 894361 ggtaaaattg tggacttcca ctacccgggc cttgatgaag tggagcagct cgctgcccac 894421 gtcacgggct tcaaggtaag ccaccaccgt ttagaaattt acggcgtctg ccaagagtgt 894481 tcgaaaaaag aaaatcatta aaaataagct gaccgcacga aacggtcagc ttattttatt 894541 tcgacatttt ctttttatta taagactcat caaattcttt tccttctaat cccttatcta 894601 aagtcagcgg ctctcggcaa tgcatgcaca tatcgactac tcctaaaacc tttgtctctt 894661 tatcacagcc tggacaaatg acgcgaaccg ctttagtcga aagcattccg atccaaaagt 894721 aaactaccgt gctgagaccg atggataaaa gcccaagtat cataaacaaa ctagaaagca 894781 aaactgactc tttgaaaaag atcccgatgt acataatgat aaacccaacg aaaaccaaac 894841 ttaacgcaaa tgttctgatt ttattaattt tgctggagta tttcgccatg tccatccccc 894901 tctgttttaa ctatagcaca aacccgatgg gattttcttc atgttttcgg ttgaactgga 894961 atttacatat ggagagttac tgtgaaattg tttataatag ttcaatgtgt ttagaaaaaa 895021 ggaatttcgt tttaaccata gaattgaatc aaatagagaa taaaaaaatt tgaacaattg 895081 cattggagga atagtgatgg aaaatcttct ccgtccaatt taccaagaaa gagcaagtca 895141 ccccaataca ttggctgtca ttatgattga gagaagaaac aaaacatctt ccttaacaga 895201 taactttgat gcagctttgc tggtgattgt aaaggatgct gatgagccag tttttataaa 895261 gcattatgaa tttgatcatc aaacagcttc tttgcatgtg gtaacagatt ctcagattca 895321 agaatggatt ttgcttggaa caaatagaag aatcatagat tggattgtaa atggcagagt 895381 cttgtttgac cgtaatgaat acgtagttga actgattgac aggctgaata catttccgtt 895441 tgccgaacgt aaactgaaga tcggactcga atacggcaaa ttaatcagaa ggtatgttga 895501 agggaaagct ttttttgaag ccaatcaatt tttagatgcc tacaatgccg ttgttcatgc 895561 gctgcatcat ttagcacgta ttgaagtaat cgacagagga ttccatcccg aaaccacggt 895621 gtggagccaa gtgcgccaga tggagcccca agtgtacaaa ttatattccg agctgattga 895681 aagtcatgag agcctggaaa aaagacttga attattattc ttagcaaatg attttctcat 895741 ccattccaaa gccgagatcg gttcggcgca tcttttcgaa gtaatgaaag aaaaagacat 895801 ttggcaattc ggtgagcttc ttcaacatca tgacctaaag cactttaccc aagatcttgg 895861 cgttatgctt gattacttga cggaaaaggg acttatcaac gtctgccaga tagaaacgaa 895921 aggacaggct gtctatcacc gaggatattc ttttaaaaaa ggtgttgact ctgattcttg 895981 accgtgttat attattaaac gtcgctgatg cgcttctgag aaaacaagct cacagcggcg 896041 ggaaaataaa tcaaaaaaac atttgacaaa agaaagtcaa aatgttatat taataaagtc 896101 gcttcaacaa gaagtgaaaa tgatctttga aaactaaaca agacaaaacg tacctgttaa 896161 ttcagttttt aaaaaatcgc acagcgatgt gcgtagtcag tcaaactagg gcctgcacga 896221 cgcaggtcac acaggtgtcg ccgcaggatg cggtgaactt aacctgtgat ccatttatcg 896281 gagagtttga tcctggctca ggacgaacgc tggcggcgtg cctaatacat gcaagtcgag 896341 cggacagatg ggagcttgct ccctgatgtt agcggcggac gggtgagtaa cacgtgggta 896401 acctgcctgt aagactggga taactccggg aaaccggggc taataccgga tggttgtttg 896461 aaccgcatgg ttcaaacata aaaggtggct tcggctacca cttacagatg gacccgcggc 896521 gcattagcta gttggtgagg taacggctca ccaaggcaac gatgcgtagc cgacctgaga 896581 gggtgatcgg ccacactggg actgagacac ggcccagact cctacgggag gcagcagtag 896641 ggaatcttcc gcaatggacg aaagtctgac ggagcaacgc cgcgtgagtg atgaaggttt 896701 tcggatcgta aagctctgtt gttagggaag aacaagtacc gttcgaatag ggcggtacct 896761 tgacggtacc taaccagaaa gccacggcta actacgtgcc agcagccgcg gtaatacgta 896821 ggtggcaagc gttgtccgga attattgggc gtaaagggct cgcaggcggt ttcttaagtc 896881 tgatgtgaaa gcccccggct caaccgggga gggtcattgg aaactgggga acttgagtgc 896941 agaagaggag agtggaattc cacgtgtagc ggtgaaatgc gtagagatgt ggaggaacac 897001 cagtggcgaa ggcgactctc tggtctgtaa ctgacgctga ggagcgaaag cgtggggagc 897061 gaacaggatt agataccctg gtagtccacg ccgtaaacga tgagtgctaa gtgttagggg 897121 gtttccgccc cttagtgctg cagctaacgc attaagcact ccgcctgggg agtacggtcg 897181 caagactgaa actcaaagga attgacgggg gcccgcacaa gcggtggagc atgtggttta 897241 attcgaagca acgcgaagaa ccttaccagg tcttgacatc ctctgacaat cctagagata 897301 ggacgtcccc ttcgggggca gagtgacagg tggtgcatgg ttgtcgtcag ctcgtgtcgt 897361 gagatgttgg gttaagtccc gcaacgagcg caacccttga tcttagttgc cagcattcag 897421 ttgggcactc taaggtgact gccggtgaca aaccggagga aggtggggat gacgtcaaat 897481 catcatgccc cttatgacct gggctacaca cgtgctacaa tggacagaac aaagggcagc 897541 gaaaccgcga ggttaagcca atcccacaaa tctgttctca gttcggatcg cagtctgcaa 897601 ctcgactgcg tgaagctgga atcgctagta atcgcggatc agcatgccgc ggtgaatacg 897661 ttcccgggcc ttgtacacac cgcccgtcac accacgagag tttgtaacac ccgaagtcgg 897721 tgaggtaacc ttttaggagc cagccgccga aggtgggaca gatgattggg gtgaagtcgt 897781 aacaaggtag ccgtatcgga aggtgcggct ggatcacctc ctttctaagg atattatacg 897841 gaatataaga ccttgggtct tataaacaga acgttccctg tcttgtttag ttttgaagga 897901 tcattccttc gaaacgtgtt ctttgaaaac tagataacag tagacatcac attcaattag 897961 taatacaaga tatcacatag tgattctttt taacggttaa gttagaaagg gcgcacggtg 898021 gatgccttgg cactaggagc cgatgaagga cgggacgaac accgatatgc ttcggggagc 898081 tgtaagcaag ctttgatccg gagatttccg aatggggaaa cccaccactc gtaatggagt 898141 ggtatccata tctgaattca taggatatga gaaggcagac ccggggaact gaaacatcta 898201 agtacccgga ggaagagaaa gcaaatgcga ttccctgagt agcggcgagc gaaacgggat 898261 tagcccaaac caagaggctt gcctcttggg gttgtaggac actctgtacg gagttacaaa 898321 agaacgaggt agatgaagag gtctggaaag gcccgccata ggaggtaaca gccctgtagt 898381 caaaacttcg ttctctcctg agtggatcct gagtacggcg gaacacgtga aattccgtcg 898441 gaatccggga ggaccatctc ccaaggctaa atactcccta gtgaccgata gtgaaccagt 898501 accgtgaggg aaaggtgaaa agcaccccgg aaggggagtg aaagagatcc tgaaaccgtg 898561 tgcctacaag tagtcagagc ccgttaacgg gtgatggcgt gccttttgta gaatgaaccg 898621 gcgagttacg atcccgtgca aggttaagca gaagatgcgg agccgcagcg aaagcgagtc 898681 tgaatagggc gcatgagtac gtggtcgtag acccgaaacc aggtgatcta cccatgtcca 898741 gggtgaagtt caggtaacac tgaatggagg cccgaaccca cgcacgttga aaagtgcggg 898801 gatgaggtgt gggtaggggt gaaatgccaa tcgaacctgg agatagctgg ttctctccga 898861 aatagcttta gggctagcct caaggtaaga gtcttggagg tagagcactg attggactag 898921 gggcccctac cgggttaccg aattcagtca aactccgaat gccaatgact tatccttggg 898981 agtcagactg cgagtgataa gatccgtagt cgaaagggaa acagcccaga ccgccagcta 899041 aggtcccaaa gtatacgtta agtggaaaag gatgtggagt tgcttagaca accaggatgt 899101 tggcttagaa gcagccacca tttaaagagt gcgtaatagc tcactggtcg agtgactctg 899161 cgccgaaaat gtaccggggc taaacgtatc accgaagctg cggactgttc ttcgaacagt 899221 ggtaggagag cgttctaagg gctgtgaagc cagaccggaa ggactggtgg agcgcttaga 899281 agtgagaatg ccggtatgag tagcgaaaga ggggtgagaa tcccctccac cgaatgccta 899341 aggtttcctg aggaaggctc gtccgctcag ggttagtcgg gacctaagcc gaggccgaaa 899401 ggcgtaggcg atggacaaca ggttgatatt cctgtaccac ctcctcacca tttgagcaat 899461 ggggggacgc aggaggatag ggtaagcgcg gtattggata tccgcgtcca agcagttagg 899521 ctgggaaata ggcaaatccg tttcccataa ggctgagctg tgatggcgag cgaaatatag 899581 tagcgaagtt cctgattcca cactgccaag aaaagcctct agcgaggtga gaggtgcccg 899641 taccgcaaac cgacacaggt aggcgaggag agaatcctaa ggtgatcgag agaactctcg 899701 ttaaggaact cggcaaaatg accccgtaac ttcgggagaa ggggtgctct gttagggtgc 899761 aagcccgaga gagccgcagt gaataggccc aggcgactgt ttagcaaaaa cacaggtctc 899821 tgcgaagccg taaggcgaag tataggggct gacgcctgcc cggtgctgga aggttaagag 899881 gagcgcttag cgtaagcgaa ggtgcgaatt gaagccccag taaacggcgg ccgtaactat 899941 aacggtccta aggtagcgaa attccttgtc gggtaagttc cgacccgcac gaaaggcgca 900001 acgatctggg cactgtctca acgagagact cggtgaaatt atagtacctg tgaagatgca 900061 ggttacccgc gacaggacgg aaagaccccg tggagcttta ctgcagcctg atattgaatg 900121 ttggtacagc ttgtacagga taggtaggag ccttggaaac cggagcgcca gcttcggtgg 900181 aggcatcggt gggatactac cctggctgta ttgaccttct aacccgccgc ccttatcggg 900241 cggggagaca gtgtcaggtg ggcagtttga ctggggcggt cgcctcctaa aaggtaacgg 900301 aggcgcccaa aggttccctc agaatggttg gaaatcattc gcagagtgta aaggcacaag 900361 ggagcttgac tgcgagacct acaagtcgag cagggacgaa agtcgggctt agtgatccgg 900421 tggttccgca tggaagggcc atcgctcaac ggataaaagc taccccgggg ataacaggct 900481 tatctccccc aagagtccac atcgacgggg aggtttggca cctcgatgtc ggctcatcgc 900541 atcctggggc tgtagtcggt cccaagggtt gggctgttcg cccattaaag cggtacgcga 900601 gctgggttca gaacgtcgtg agacagttcg gtccctatcc gtcgcgggcg caggaaattt 900661 gagaggagct gtccttagta cgagaggacc gggatggacg caccgctggt gtaccagttg 900721 ttctgccaag ggcatcgctg ggtagctatg tgcggacggg ataagtgctg aaagcatcta 900781 agcatgaagc ccccctcaag atgagatttc ccattccgca aggaagtaag atccctgaaa 900841 gatgatcagg ttgataggtc tgaggtggaa gtgtggcgac acatggagct gacagatact 900901 aatcgatcga gggcttaacc atatttttga atgatgtcac acctgttatc tagttttgag 900961 agaataagtt tttcaaaaaa acacttgatt ttctcaagaa tacatagtat aatgttaaat 901021 gtcactgaaa ttgtctggtg atgatggcga agaggtcaca cccgttccca tgccgaacac 901081 ggaagttaag ctcttcagcg ccgatggtag tcgggggttt ccccctgtga gagtaggaca 901141 tcgccaggca gacttcattc cgcagtagct cagtggtaga gctatcggct gttaaccgat 901201 cggtcgtagg ttcgaatcct acctgcggag ccattattgg agagctgtcc gagtggtcga 901261 aggagcacga ttggaaatcg tgtaggcggt caactccgtc tcaagggttc gaatcccttg 901321 ctctccgcca ctgatactta tacataatta caattgaaag tctgggcccg ttggtcaagc 901381 ggttaagaca ccgccctttc acggcggtaa cacgggttcg aatcccgtac gggtcattat 901441 atgatggagg attagctcag ctgggagagc atctgcctta caagcagagg gtcggcggtt 901501 cgagcccgtc atcctccacc attatatcat cgcggggtgg agcagttcgg tagctcgtcg 901561 ggctcataac ccgaaggtcg caggttcaaa tcctgccccc gcaaccaaat tttaaaatgg 901621 tccggtagtt cagttggtta gaatgcctgc ctgtcacgca ggaggtcgcg ggttcgagtc 901681 ccgtccggac cgccatttga atacttaggc tcggtagctc agttggtaga gcaacggact 901741 gaaaatccgt gtgtcggcgg ttcgattccg tcccgagcca ccacctatgc cggtgtagct 901801 caattggtag agcaactgac ttgtaatcag taggttgggg gttcaagtcc tcttgccggc 901861 actgtttttt caaaatttaa tgtggagggg tagcgaagtg gctaaacgcg gcggactgta 901921 aatccgctcc ctcagggttc ggcagttcga atctgccccc ctccaccatt tataggggca 901981 tagtttaacg gtagaacaga ggtctccaaa acctccggtg tgggttcgat tcctactgcc 902041 cctgccaaat ttatgacatc ttgagattat ggcggttgtg gcgaagtggt taacgcacca 902101 gattgtggct ctggcactcg tgggttcgat tcccatcaat cgccccatat tatcattggg 902161 ctatagccaa gcggtaaggc aacggacttt gactccgtca tgcgttggtt cgaatccagc 902221 tagcccagtc tcacttttta tatcaactgc atataatgta ttaagtccat taaaaatgcg 902281 gaagtagttc agtggtagaa caccaccttg ccaaggtggg ggtcgcgggt tcgaatcccg 902341 tcttccgctc caattacggc ggcatagcca agtggtaagg cagaggtctg caaaaccttt 902401 atccccggtt cgaatccggg tgtcgccttc ttattgccgg ggtggtggaa ttggcagaca 902461 cacaggactt aaaatcctgc ggtaggtgac taccgtgccg gttcaagtcc ggccctcggc 902521 accaatttta cttacatggt aagttgaatt ggtgtttgtg ttttatcatt ataactaatc 902581 atattaatga tctacataag tagatcattt ttttaatgct ttgatttatc ataacaagtt 902641 aagttccgag gcctattata aagcggctgt atagctagtc tttcaacact tttattttat 902701 atttccataa aaactttttt gaaatacgtt gacactttat gagatccatg atatatttat 902761 attcgtcggt tagatacgac gtaaaacttg ccggtgtggc ggaattggca gacgcgcacg 902821 actcaaaatc gtgttccttc tggagtgtcg gttcgacccc gaccaccggt atactgaaaa 902881 acccgtttct taacagaaac gggtttttat tttttattaa agaaaaggag cctcggctcc 902941 tttttatact tactcagcgt attggtctag gatctcttct agcacctctt ctagctcttc 903001 tgtatcttca agctctgatt ggctgaaacg gacgcgtaca agctgttctc cgtcattata 903061 catctcttcc aaccaccctc ggagtcctct tgctctgcgg tcgacttcga aaatgatttc 903121 caaaccgtct tcgtctaaaa ggaaaatgag ctctaattca tcaagcatct gacgataata 903181 tccggaagtc ggaacgaatt cgaattcttg aacgaacgga agacgacgct ggaagtaggg 903241 cgcttgttcg cagtctgctt cgttaagacg gaagcccagg ttttcgattg cttcaagcac 903301 attttcaatc caagggtgcg cttcaacgaa aatgcggtca tgatcggatt tatcgatacc 903361 gccttgaatg tcaaggtctg tcaccacggc aacctctact ttccctacag tgatcggcgt 903421 atctagaggc agagtgaatg tgaacggaaa ttgatgctct tcaccaggct gtatggtaaa 903481 tgaaccagtg acccggaaag aatgaattgt agcgtatttc cggtgctctt catcgtcttt 903541 tacaatgaca taccgtgtgc taagctgtaa atcgatataa cggatgtcct gagcgatttt 903601 tccgcctttg acatgtaccg ttccctgtac ttcttctcct ggaaaatatg cgtctttttc 903661 taaaattgta tctacttttg cagctccaat tccggcactt gccgcaagct tcttaaaaaa 903721 tgacatgtta gatcttcccc tttttctttt ttctcaacag atatacgtaa gaaggaggaa 903781 aaaagattcg tttgattcat acttttttcc tattattcgt ctcggcctag ggacagacta 903841 agaataatat tgaaaataaa ggagtcgatg gaagtgaata aagaaagttt ggttgcagat 903901 gaattacaca gaatgttttt ggctggtgag ctgcaaatca cagtagagga ggatataaac 903961 aatatttccg aaaggctgag aaacggcgat ctcagtttag accgattaag cggtgaagac 904021 gtgtttataa aagaaacggt aaatgaggct ttaagaagag tggagcaata aaaaagagac 904081 ggcatctcat ctttgagatc ccgtctcttt ttgtggtctt tgctgtaaga taaaagcgaa 904141 tcgatttgga attgctcacc cgagccaccc cttttctaac agaagatctg acagttcatc 904201 atggagataa acagctgtat ctaattgatc atgcaatgct cttctgatgt ggggattttc 904261 ggttgctgtt gttgcgacag tgtatttgtt aatgctggtt tttattgttg ttaacaaatc 904321 aagaatatct ttgggacaaa gactttgttc aatgggaaac cacctccttt gtttttttag 904381 cagctcctga taagaaagta tttgactttg tttcttgctt ctatacaaaa tgctataata 904441 agcaacaaat tttgttgggg ggtgtgatga tgaagcagat tattgcgatg gggggcgggg 904501 gtttttcgat ggagccggat aatttgtccc tcgatcaata tatcctcaat caatcaaaac 904561 gagagcagcc tcgtatttgt tttttgccga cggcgagcgg agattcccaa aactatattc 904621 agcggtttta tcatgcattt caaacattgg attgcgtgcc gtctcattta tctttgttta 904681 agccaccatc atcagattta gtttcttttg ttatggaaat ggacgtgatt tatgttggcg 904741 ggggaaatac gcggaattta cttgtgttat ggaaagagtg ggggctggac catattctca 904801 gggaagcatg gaagaacggt gtggttgtag ctggaataag tgccggtgcg atctgctggt 904861 ttgaagaagg ggtgacagat tcagccggac cgctgacaag tttgaaaagt ttaggttttt 904921 tgcaagggag cttttgtccc cattatgacg gggaaaagga tcggagaccg gcataccacc 904981 agctgatatc taacaagttc ttatgcagtg gctatgcagc ggatgatggg gctgctctcc 905041 atttcataaa tgatcagctg tttcagactg tgagttcaag gtcgggtgca aaggcatatc 905101 gggtgatgat ggctgaacat gaaatagctg aaatcccgtt gccggtcaaa tatttagggt 905161 gaaattggct gaatattatc tatattcctc tttttttcag attgatttta tgataagatg 905221 agtgcgaaat caatagttac tgggggtgcc cgctttcggg ctgagagaga aggcaagctt 905281 cttaaccctt tggacctgat ctggttcgta ccagcgtggg gaagtagagg aattgttttt 905341 gttattgtct tgctgggcaa taatatgttt ctttctgact gtaaccgggt tcatttatat 905401 gaatccggtt ttttgtgctg gttatgggct tgattttgtc ctttcaaacg tagaaagggg 905461 aaggaaaagt aatgcaaaac aattcagtgc agcaagccaa catttccatt atgtcaagtt 905521 tttcaggcag caagaaggta tacgtggagg gttcttcttc ggacatccaa gtgccgatga 905581 gggagattgc attgagtccg acgacgggat cgttcggcga agaggaaaac gcgcctgtgc 905641 gtgtctatga tacaagcgga ccgtatacgg accctgaagt aaccattaat attcaagaag 905701 gattaaagcc gctccgccaa aaatggatca cagagcgcgg tgacgtggaa gagtatgaag 905761 gtcgggctat aaaaccagaa gataacggtt ataaaaaagc aaaaccaaac gtaagctatc 905821 caggattaaa gcggaaaccg ctgagggcga aggcaggtca aaatgtcaca caaatgcact 905881 atgcaaaaaa ggggatcatt acacctgaga tggaatttat cgccattcgt gagcatgtgt 905941 ctcctgaatt cgtcagagac gaggtagcca gcggccgggc gattattcct tcaaacatta 906001 atcaccctga aagtgagcca atgattatcg gccggaattt tcatgtgaag attaatgcaa 906061 atatcgggaa ttcagcggtt acgtcatcca ttgaagaaga agtggaaaaa atgacgtggg 906121 ccatccgctg gggagcggat acgatgatgg atctctctac cggaaaagat attcatacga 906181 cgcgtgaatg gattatccgc aattgccccg tgcctgtggg aactgttccg atttatcagg 906241 cgcttgaaaa agtaaacggc gtagctgagg atttaacgtg ggagatttat cgtgatacgc 906301 taatcgagca ggcagagcag ggagtggatt attttacgat tcacgcgggt gttttgctta 906361 ggtatgtacc gctgactgcc aaacggacaa ctggtatcgt gtcacgcggg ggagcgatta 906421 tggcgcagtg gtgtctggct catcatcaag aaagcttttt atacacacat tttgaagaaa 906481 tatgtgagat tatgaaaatg tatgatattg ctttctctct tggggatggt ttgcgtcccg 906541 gatcaattgc tgatgccaat gacgaagcgc agtttgctga attagagacg cttggagagc 906601 tgacgcaaat tgcctggaag catgatgttc aggtgatgat tgagggtcct ggacatgttc 906661 cgatgcataa aatcaaagag aacgtcgata aacaaatgga catttgtaaa gaagcgcctt 906721 tttacacatt ggggccgttg acaacggata ttgctccggg atatgaccat attacttcag 906781 cgatcggagc ggcgatgatc ggttggtacg ggacagcaat gctttgttat gtaacgccga 906841 aggagcattt ggggctgcca aaccgtgatg atgttcgtga aggagtcatt acatataaga 906901 tcgctgcgca cgctgcggac cttgcaaaag ggcatcccgg agcgcaaatc cgggatgatg 906961 cgttatcgaa agcccgtttt gaattccgct ggcgggatca gtttaattta tctcttgatc 907021 cggagagagc ccttgaatac catgatgaaa ccctgcctgc tgaaggagca aaaaccgctc 907081 acttttgttc catgtgcggt ccgaaatttt gcagcatgag aatttcacag gatattcggg 907141 attatgcgaa gaaaaacgat ctcagtgaag cagaagccat aaataaagga ttaaaagaaa 907201 aagcaaaaga gtttgtcgat acgggaagca atttatatca ataaaaaaaa tgaagatgga 907261 gaatgctcca tcttcatttt tttagaaaaa cagagagcgt cgaagcggag gaatactctg 907321 ttcaaagcgg aaaacatttt ctggatcata tgtcgttttg acacggcgga gtcgttcaac 907381 gttttcgccg taatatgttc ttggccagtt tctgatttcg atatctggcc aatttacgta 907441 gtctcccatc gtttctttcg aaagggacgt tctcagcccc tcaatccagc ggacattttg 907501 tcttttttct ccaggggatg tccagtttgt taagtattcc tgggcgatga ttgcgtcacg 907561 ataataaaat gccgtttggt cgggagcgac ccgtccggct gccccgccga gtgcttgctg 907621 ccagacactg gcgttttgat tcggagcgtg ctctaaaaag tgttttattg ttgagatcgc 907681 acgttctgat aatggctttt caatgaaaga gccggagcgt ttcatttttt gaggctgatt 907741 gcctcccggg ctgttaaaaa aggttaccgc ttcaatgaat ggcgttgttt ttaccattcc 907801 gcttgtcgga cttcctgctt tcaataaagg ctttaacagt ttttttaact ctgtttttgg 907861 cccgacaaat tggccgaggg cttctatgcg gtttacttct ttaggccaaa actctattga 907921 tgatgtaagc cggtcatctg tatacggggc ccagttctgc cacgtgttat atacttcctc 907981 aaaatcatcc catccccatg taatagaaaa aatcgacact tgagagatgg gcactgcttt 908041 aaatgtcatg gaggtgacta tgccgaaatt gcctcctccg cctccctgag acgcccaaaa 908101 taagtctgga tgatttgaac agctgactgt aatcagatca gcgccctctt tttcgtctgc 908161 tacgatcatc tcaagctgca cgaggctgtc gcaagtaaga ccggcagccc ttgttaaaag 908221 tccaattccc cctccgagag ttaaacctgt gagccctaca ttagcaatgg tgcctgcggg 908281 aagcgtcagg ccgtattgcc agagtgtccg atagacttct cccaattcag cccccgcttc 908341 aatataggcc agctttttat cctgattcac agttattttt ttcatctcgc ttaaatcaat 908401 aacaagaccg ttatttaaaa gggaaaagtt ctcatagctg tgtctgccgc ctctaatacg 908461 gaaaggcaca cggttttcac gcgcccattt cagcgcattg agtgcatcct gtttgttttg 908521 gcaaaacaca atgatgtcag gatacctttc taagcttagg ttaatattgg ttcttgcttc 908581 gttatagtcc ggatcatccc gtgtcacgat acgtccggtc aattttgtct tttccacact 908641 cccacatctc tttctctcgt attctagttt ctctagctta tgcgtcaggg gaaaagagtg 908701 tataaggaaa aagcggggat gcaatctgat acagtgtcaa caccctcaaa aaatagttga 908761 caggtcggta ttgtatgaat taacatggtc agtacaaatt tttcaaattt atcgcgctga 908821 tcggaacacc gaaggctctt atcgtttaga taagggcctt ttttgtatga aaaagggggg 908881 attattgatg ggagtcaaaa aagaaaaggg gagaaaacga ttcaggaagc gaaaaaccta 908941 cgggaatcag attttgccgc ttgagctgct gattgaaaaa aacaaacgag agattataaa 909001 cagcgcggaa ctcatggaag aaatttatat gaagattgat gagaagcata cgcaatgtgt 909061 aactaaatat aaaaaaaccc gctgactaca acgggttttt gcatttctcc attaagaatc 909121 ttttttaatc ggcaatccaa ggccttctgc cacgcgtttt ccgtattcag gatccgcttt 909181 gtagaagtgc tcgatttggc gcagcttgat ttcttctttt tctaccggct tcatggcatt 909241 aacgatattt tcaacaaggc gggtacgttc atcttcactc attaaacgat acagatcgcc 909301 ggcttgagtg tagtgatcgt agtgatcgta gcttacgctg tcagcgatac cttgtaccgg 909361 atatgctgct tgcttatcct caggtgactc ttttggaccg ccgaagctgt taggctcgta 909421 atacacagat ccgccgccgt tatcatcaaa acgcatttgc ccatcacgct gataattgtt 909481 tactttgttg cgtgcgcggt tgattggcag cgcttgatgg tttgcaccga cacggtagcg 909541 gtgtgcatca tgataagcaa aaagtcgacc ttgaagcatt ttatccggtg aaacatcaat 909601 accaggcacg agggttccag gtgaaaatgt cgcttgttct acctctgcaa agtagttttc 909661 cggatttctg tctagaacca tgcgtccgac ctcgattaac gggtagtctt tttgagacca 909721 aacttttgtg acatcaaacg gatcgaaacg gtacgtattt gcatcttcta aaggcatgat 909781 ttgcacatat agtttccatg caggataatc accgttttcg attgcgttga aaaggtcttc 909841 tgtatggtaa tcagggtttt caccggcaat ttttgctgcc gtattgacat caaggttttt 909901 cacgccttgt tctgttttaa agtgatattt aatccatacg ccttcgcctt cggcatttgt 909961 ccatttgaat gtatggcttc cgaagccgtg catgtggcga agtgtcgcag gaattccgcg 910021 gtcagacatc aggattgtca cttggtgcag tgactctggt gaaagtgacc agaaatccca 910081 tacagccgta gggtttttca ggtgtgtttt tggatctctt ttttgtgtat ggatgaaatc 910141 agggaactta atcgcatcgc ggataaagaa tacaggcgta ttgttgccga cgatgtcgta 910201 gtttccttct tcagtataaa atttaacagc aaatccgcgc gggtcgcgaa ctgtgtcagc 910261 agagccaagt tcaccggcaa ctgttgagaa acggatgaac aacggtgtgc gtttgccgac 910321 ttcagaaagg aaagcggctt tcgtgtattt tgttacgtcg tttgtcactt caaaatatcc 910381 gtgtgcgcct gctcctttgg cgtgaacaac acgttcagga acacgttctc ggttgaaatg 910441 ggccaatttt tcgagtaaat gtacatcttg aattaaagtt ggtccgcgag aaccggcagt 910501 cattgagttt tgattatctc caaccggagc gccccagcta gttgtcagtt tatttgaact 910561 catgttatca cctcttggaa tttataagaa cataatatca tctctaagta aaaagtcaat 910621 attattttat aattattata aaatagttat ctctattaat cgatatatag tatcgaaatt 910681 gttgaaaaac cttgttgtaa cagcttttta tgacacttaa taatttttgg agaaataatt 910741 tttccttctc tatttgcgaa acaagcagag taagtgataa acaaggatat caaaaatcgt 910801 atttaaaaaa gagttgacat atcggaataa tttgaattaa catgttattc aaacaaaaaa 910861 acaattgggc agctgatcgg accgccgaag gctctcatct ctacaagaac agagatgggg 910921 gcctttttgt tttttttgaa ggcggggttg gcagaaagag agggataaaa gtggctgtga 910981 ccatcagcat caaagaaaag gcatttgttc aagaaggccg caaaaacacg gtcttagaaa 911041 acatagaatt atcaatcgca ccaggcgaat ttctaacgct tatcggaccg agcgggtgcg 911101 gaaaaagcac cctgttaaag attattgcag ggcttgattc tgaatatgac gggagtgtgg 911161 aaattaacgg ccgcagcgta acagctccgg gtattcagca aggatttatt tttcaggaac 911221 accgcctctt tccttggctg actgttgagc agaatattgc agccgacttg aatttgaagg 911281 acccaaaagt caaacaaaag gtggatgaac tgatcgagat tgtcagattg aaaggatcgg 911341 aaaaagcata tccgcgcgag ctgtcaggcg gcatgtcaca aagagtagcc atcgcccggg 911401 ccctgctgcg ggagcctgag gtgctgcttt tagatgaacc gtttggtgca ctcgacgctt 911461 ttacaagaaa acacctgcag gacgtgctgc tggatatatg gaggaagaaa aaaacaacga 911521 tgattctcgt gactcatgat atagatgaat ctgtttattt aggaaatgag cttgcgatcc 911581 ttaaggccaa accggggaaa atccataagc tgatgcccat tcacctggcg tatccgcgaa 911641 accggacgac tccggatttc caagcgatca gacagagagt gctgtcggaa ttcgagaaaa 911701 cagaagattt ggagtacgca gaaggatcag ggatatagaa agggcggaag cggaaatgaa 911761 aaaaggactc attgtattgg ttgccgttat ttttctgctc gcaggctgtg gagcaaatgg 911821 agccagcggt gaccacaaac aattgaagga aattcgtatt ggtattcagc aaagcttaag 911881 cccccttttg attgcaaaag aaaaaggctg gttcgaagat gcatttgaaa aagaaggcat 911941 caaagtgaaa tgggtggagt ttcaaagcgg tccgccccaa tttgaaggcc ttgcggcaga 912001 caaacttgat ttttctcaag tcggtaattc gcctgtgatc gctggacagg cggcaggcat 912061 tgactttaaa gaaatcggtt tgtctcagga cggcttgaaa gcaaacggca tccttgtcaa 912121 tcaaaacagc ggcattcaag acgttaaggg cttaaagggg aagaaaattg cagtcgccaa 912181 aggcagcagc gggtttgatt ttttgtataa agcgcttgat caagtggggt tgtcagctaa 912241 cgatgtgaca attattcagc ttcagcctga tgaagcagct tccgcatttg aaaacggatc 912301 tgttgatgcc tggtccattt gggagccgta cttgtcctta gaaacaatga aacacggagc 912361 aaaaatcctt gtgaacggag aaagcacaga tttatattca ccgggtttta ctttagtaag 912421 aacaaagttt tcagaagagc atccagacga agtggtccgt tttctgaagg tgtttaataa 912481 agccgttgta tggcaaaagg aacatctgga tgaagcagcg gacttatatt ctgacattaa 912541 agatctcgat aaaaaggtcg tcgaaaatgt gctgaaaaat actgagccac ttaatgagat 912601 catcagtgac gacattgtga aagcacagca ggaaacagca gattttcaat ttcgaacaaa 912661 ggcgatagat aagaagattg atgtgaagga tgttgtcgat aacactttta tcaaaaaagc 912721 attagaggag cattcctcag gaggtgatca atgatgaaag cagaggctgc gggctcgctg 912781 cccaaaacga atgcggaagc ggtgcgaaaa aagcccggaa ggaagagata cggctggatg 912841 aaggggcttt tactgcccgc tgtcatcatt gccatctggc aggtcatcgg cgggctgggg 912901 gttgtgtccg ctacagtgct gcctacacct gttacgattg ttctgacctt taaggagctt 912961 attttgtccg gcgaactgtt cggccatctg caaatcagca tttatcgggc ggcacttggt 913021 tttttgcttg gcgcggggct tggattgatg atcgggattt tggccggatt ttccaaacgg 913081 acggagctgt atcttgatcc gtcgttgcaa atgcttagaa ccgtacctca tctggccgtc 913141 acgccgctgt ttattttatg gttcggattt gacgaagtat ctaaaatttt gctgattgcg 913201 ctcggtgcct tctttcctgt ctatatcaat acgtttaacg gcatccgcgg ggttgacgcg 913261 aagctgtttg aagtcgcccg ggtgcttgaa tttaaatggc atcagcagat atccaaagtg 913321 atattgccgg cagccctgcc caatatattg ctaggcattc gcttatcgct cggcattgca 913381 tggctcgggc tcgttgtggc agagctgatg ggctcaagct cgggagtcgg ctatatgatc 913441 atggatgcga gacagttttc acaaacgaat aaagtctttg cagggattat catttttgca 913501 gtggttggaa agctgacgga ttccttcgtc aggctgcttg aacgaaagct gttaaagtgg 913561 agaaacagct acgaaggata aaagatataa aggggagatg aatatggaaa ttctttggtt 913621 tataccgact catggagacg cgagatattt aggatctgaa agtgatggac ggactgcgga 913681 tcatctttac tttaaacaag tcgcgcaggc ggcagacagg ctgggatata caggagttct 913741 tctgccaacg ggaagatcgt gcgaggaccc gtggcttaca gcgtcggcac tggcaggaga 913801 aacaaaggac ttaaagtttt tagtcgcggt aagacctggt ttaatgcagc cttctctggc 913861 agccagaatg acatccaccc tagaccgcat ttcagacggc cggctgctga tcaacgttgt 913921 ggcagggggc gatccgtatg agctggcagg cgatggcctg tttatcagcc atgatgagcg 913981 ctacgaggca acagacgaat ttttaaccgt ttggcggaga cttttgcagg gagaaacggt 914041 ttcctatgaa ggaaagcata taaaagtgga aaacagcaat ctgcttttcc cgccgcagca 914101 agagccgcat ccgcccatct atttcggtgg ttcgtcacag gctggaattg aagctgccgc 914161 aaagcataca gacgtgtact tgacatgggg tgagccgcct gaacaagtaa aagaaaagat 914221 agaaagagtc aaaaagcaag cggcaaaaga agggagatcc gttcgatttg gcattaggct 914281 gcatgtcatt gcccgtgaaa ctgaacaaga ggcatgggaa gcggcagagc gcttgatcag 914341 ccacttggat gatgacacca ttgccaaagc gcaggcagct ttgagccgtt acgactcttc 914401 aggccagcag cggatggccg tccttcatca aggcgatcgg acgaagcttg aaatcagccc 914461 gaatctgtgg gcggggatcg gcctggtcag aggaggggca ggaacagctc ttgtcggtga 914521 tccgcagacg attgccgacc ggatagcgga gtaccaggca ctcggcatag aatcgtttat 914581 attctccggc tatccgcatt tagaagaagc gtattatttt gcagagcttg tatttccgct 914641 tttgccgttt gaaaatgatc ggacgagaaa gcttcagaac aaaaggggag aagcggtagg 914701 aaacacttat tttgtcaaag agaaaaatgc atgagtttaa ctaaaataca gccccccgaa 914761 catggtatga tattcaaaaa aagggggctt tttttctgaa aacattgaga agcgcggcag 914821 tcatttgcct catagctatg ctgtcagcat gcggacattc aaaacagatg gaaatcaaag 914881 cggcggacat atcagatctt gaaaaaaaca gaatggatgt cgcagcttca caggcattca 914941 ctgccgaagc cgtcaatatc ggtgaaggta tttcttcagc tgacatgtac atcgaacatt 915001 atcaaaaggg aaagcttgtt gagaggtttg gaccggttcg tgcagattat tcagaggaaa 915061 aaactgatac catacaattt gtttattttg agaatgaaga gggggaagga aagaataaac 915121 ataccaccat tcattttggc attgtggata aacagggaac tatagcggct gattcatcgg 915181 tgaaacgcga cgatagcaca acacaggaaa tgactcagaa tatttcatcg ccggaaccga 915241 ttactttcga gaagcctgct ttgatcggca gcagtattag agggactgac gagacaatgc 915301 acacctctga acataaaaaa gagctcatta agcatcaaga tgcgttactg tattatgtgg 915361 aattgcatca ttagaatggg cggcttcagg ccgtctgttt tacaaagcgg tatgcttgct 915421 tttttgaatg gtgaatgata cattttaaat cgtaacaatt tcgatttaaa gggaggctat 915481 gtgacttggc taaaaaatca aaagtggcaa aagagttaaa acgccaacag cttgttgagc 915541 aatacgctgg tattagacgc gagttgaagg aaaaaggaga ttacgaggca ctcagcaagc 915601 tgccaagaga ttcagcaccg ggaaggcttc acaaccgctg catggtaacg gggcgcccga 915661 gagcatatat gaggaagttt aaaatgtcca gaatcgcttt cagggagctg gcccataaag 915721 gccagattcc cggtgtgaaa aaagcaagct ggtaagaaaa aactccggcc gattacagcg 915781 cgccggagtt tttttcgttt ttcttgaaag agatgacgta ggaaaggtgc tggatgatca 915841 tgatgataaa cacaataata atagggaaaa acggaatgcg cgattgaaat agcggataaa 915901 aaatgagaag aaccgctgcg gcaggcagcg agaagtagac agcgatatat gacgcgcgac 915961 atgcttttgc cgtcatcatc tgctctcttt catcctgctc ttcaaactca tcaggcagaa 916021 gtagctgctt tctggcaggg cggctttttt tctgtaagta caaataaacc gcagacgccg 916081 caacaaacag aataaaggga gtgaggttta aatcaaatac catcccgccg ctctttgtgc 916141 cgaaaaaaga tgctatgcct tctgaggctt caaagtatga aatcagcgcc cagcatgcaa 916201 ggccaaataa aacaaggtga aaagctgctt ttgttttcat gctcatctta gttttcctcc 916261 tctaaccaaa agacatcctc cattttcatg gagaaggctt tgcagatttt cagtgctaac 916321 agcagtgagg gaacataatc gcctttttca atcgctgcca cagtctgtct tgtgacgccg 916381 accgtttctc cgagtttttc ctgagaatag ccgaagcgtg ccctcagctc ttttacttta 916441 tttttcatca tgacgtctgt ccccttcaca atctcgattg attatattgt atagtatact 916501 taacattatg taaatggaac ttaacaactt tacaaaaaga taactttttt tcgacaaaat 916561 ttttatattc ccttgacgaa aaataaataa acatgtaata taaaaaaagt cagagcggta 916621 ctgttgctga caatcacaaa tgcgggtgta gtttagtggt aaaacctcag ccttccaagc 916681 tgatgtcgtg agttcgattc tcatcacccg ctccatacat acgttattaa cgcagtgttt 916741 cgtttctcag ataaacgaag tattgcgttt ttttatgtga aaaagaacac ggtattcgtg 916801 ttcttttacg taagccaatg tactgtatgg gtgccgccgt gaatttgttc aaacattttc 916861 gttaatgatg ataagaggtt aacagcgctg cttttctcaa tcgatggcgg gaaaaaaatg 916921 atttgcagca tattcttagt ctcgtttgaa acgggatagt ggttgacgct gtttttgaaa 916981 tcgccaaaaa tgccgttttc atcagagaaa agcagtatgt tttctttttc tcccaatgag 917041 atccggaccg gctcatgaag ctttccggca tcataaatca taataggcag agaatatttt 917101 aatgcgaaaa aatcgattgt gtcatgggcc gagtctttac tttccatgaa ttgttccttg 917161 gatatcggga ccagcatgtc ctccattggg gttgtttctc cctcaaatga agggttaagc 917221 tgtttaaaga gtttctgcca ttccttgacg aaggattcat cggatatacc gccgtccgca 917281 tagtcgaaaa acaaggattc ttgaaacagg cggagtctgc ctttcagcat ttgcggtgag 917341 gagccgactt cgatattctc ataaatgaca gcagctgcat gtaagccggc cgcacgttca 917401 gtaataacag aatcaagttt gatattcact agcattcact ccagttacgt gatatcaacc 917461 tattataaac gctgtgtcgt tttatcacaa agaaaggagg ctgtgcaaaa catgaacgtt 917521 tatcagctca aagaagaatt aattgaatac gcgaaaagca ttggcgtaga caagattggt 917581 tttacgaccg ctgatacttt tgacagttta aaagaccgtt tgattcttca agaatcactc 917641 ggctatctct ccggctttga agagccagat atcgaaaaaa gggtgacgcc gaagcttctt 917701 ttgccgaaag cgaaatcaat agtggcaatt gctctcgcat atccttccag aatgaaggat 917761 gcgccgagaa gcacgagaac tgagcgcagg ggcatttttt gcagagcttc ctggggaaaa 917821 gactatcatg atgtgctgag ggaaaagctt gatctgctgg aggattttct aaaaagcaag 917881 catgaggata tcagaacgaa gtcaatggtt gatacaggtg aattgtctga tcgcgccgtt 917941 gcggaacgtg ccggaatcgg attcagtgcg aaaaactgta tgatcacaac acccgagtat 918001 ggctcttatg tgtatttggc ggaaatgatc acaaatatcc cttttgagcc tgatgtgccg 918061 attgaagata tgtgcgggtc ctgcacgaaa tgcttggacg cctgcccaac gggagcactg 918121 gttaatcccg ggcagcttaa tgcgcagcgc tgcatctctt ttctgaccca gacaaaagga 918181 tttttgcctg atgaattccg gacaaaaatc ggaaaccgcc tgtacgggtg cgatacgtgc 918241 caaacggtat gccctctcaa taaagggaag gattttcatc ttcatccgga aatggagcct 918301 gatcctgaga ttgccaaacc gttattgaag ccgcttttgg ccatcagcaa tcgggaattt 918361 aaggagaaat tcgggcatgt ctcaggttct tggcgcggaa aaaaaccgat tcagcgaaac 918421 gccattctcg cgcttgccca ttttaaggat gcttccgcac tgcctgaatt gacggaactg 918481 atgcacaagg atccgcgtcc tgtcatcagg gggacagccg catgggcaat cggaaaaatc 918541 ggagaccccg cctacgcgga agagcttgaa aaagcgctgg aaaaagagaa ggatgaagag 918601 gcaaagctgg aaattgaaaa aggaattgag ttgctaaaag cttcaggcat gactaaacaa 918661 ggcctgtcct gacatacgta tagagcagaa ggaaaaaaca cttgagatca tccaagtgtt 918721 ttttctctat aaaaaagtat ggcgggtggg gtgagcttga agtacatttt agaacaatta 918781 gcggaggagc ggctgggctt tctggttaac gggcatgcta tgagacagga gtctcaagtc 918841 ggagacctta aagtcatgga gcgtaagaaa aagcttctgg aaaaacgtaa agttgacatc 918901 ataaaagcga aagcaaaggc cgtgattaat catgtgcggg ttgaggatga cggaacgacc 918961 tgcctttcgt ataccatcca ttacgaatac gtgtgtaagg aacaagatga cagcttgtat 919021 atagaagagc acatagagga gcgaatggct ttcctgtatg atcacatttt gattagtgat 919081 caggaaattg cgaaaaagcc ggctggattt catgaaggga ccagtattat tgactattct 919141 gaagctgaag aggaaagaga agcgtttggc agggcttttc aatacgatcg tctcggcgct 919201 gtccaatatg ccgagaaatt ttggaacaag cgcaatcctg cttataaaaa tttcagcgat 919261 aactgtacaa attttatttc tcagtgtctt catgcaggag gcgcgccgat gcgcggtcat 919321 ccgaacaggg gatcaggctg gtggatgaaa caaagctcat ggagctacag ctggacggtg 919381 gctcactcta tgaaaatgta tttgtcgaat tcaaaggccg gactgcgtgc ggtgcgggtg 919441 aaatcagcgg aagaactgat gccgggcgat gtgatttgct atgacttcga aggagacggc 919501 cggtttaatc atacaacgat tgtcgtggca aaggacaaag gcaatatgcc gcttgtcaac 919561 gcccagactt atgacagcag gatgaggtat tggtcatatg aggattctac ggcatacacg 919621 ccgtcaatac gatatgcctt ttttcatatc gttgatgata cgacaaaaga gtaattaatg 919681 ttataatgat gggcggataa gaaaaacaga ggtgaacatt gtggcattac atgtcgtttt 919741 atatcaacca gaaattcccg ctaacacagg gaatattgca cgtacttgtg cagcaaccaa 919801 tacaacgcta cacctgattc gtccgctcgg cttttcaacg gatgataaaa tgctgaagcg 919861 tgccggactc gattattggg agtttgttaa cgttgtgtat catgattcgt tagaagaatt 919921 gtttgaggca tataaaaaag gcaagttttt ctttattaca aaatttggcc agcagcctca 919981 tacatcattt gattacactg atcttgacga ggattatttc ttcgtgttcg gaagagaaac 920041 aagcggtttg ccaaaggatt taattcaaaa taatatggac cgctgcctgc gtcttccgat 920101 gacagagcat gtcagatcgt taaatctgtc caatactgcc gcgattcttg tttatgaagc 920161 gctgcgccag caaaattacc gtgatttaaa atagtgaaaa acccgctcat cgatgatggg 920221 cgggtttttt tgcggatgtt gaaatgcttt gtttcgtttt tgggcttaac aacgtaacag 920281 tgttatgtta caatgtaccc atcaaaggag ctggacttat ggaagaacaa ttaatctcta 920341 aaaaagaatt acttgaaaga acatcgattt catacggtca gctgtatcga tggaagcgga 920401 aaaacttaat acctgaggaa tggtttattc gtaaatccac atttacaggg caagagacgt 920461 tttttccgag agaggagatt ttaaaacgta tatcaatgat tcaaaagatg aaagaaaatt 920521 tgtctttgga tgaaatgagg gaaatgctgt cgccgaaaat gaaggatgtc agcatgaccg 920581 ctgatgaatt gcttcataaa ggtttggttt caaggcctgc tcttgaagcc tattcagaag 920641 acggaggaag tccggttttt tcatccagcg atttgctttc gctgtttgtg cttgagggcc 920701 tgctgcagtc tggaaatgtc agccttgcag aagcaaaaat ggctgcagag gtattaaaga 920761 agcatgatac tgaagagatt gaaaaacaga cggagctgat tgtgctccgc aagctcggtg 920821 tcacaacttg ttttatagcg gctgcggcgg acagcatttt gtttgaatca tccgtaaagg 920881 ttgtggaacg ggtagattta ttaaaagctt cagaggaatt aaaaacaaca tttatgcagg 920941 agggccatca atggatgtag tggaaaagct ggtgataaat ggatcaggaa gttctaaggg 921001 aggaacattt caatcagttg agattaatgg cagcgggaca gtggccgggg acgtggagtg 921061 tgacactttt tcttttaatg gaaacggaaa agcggacggc agcgtcaaag cgaaagcggt 921121 aactatcagc ggttcaggaa agatacatgg agacgttgaa gcagaatcta tccggatgaa 921181 tggcactggt tttattcaag gagaggtatc tgcaaaacaa ttgaaaatcg ctggatcatc 921241 aacatttggc ggcactgtca aggctgatgg aattgacatt agcggaaaag ctgtcatgga 921301 agcagattgt gaaacagaaa cctttcaatc agaagggaaa tgcaaaatca gcgggctttt 921361 aaatgcagac caggtgatca ttaagctttc tgcaggggaa agctatgcgc gggagatcgg 921421 ctgccgccat cttcaagtga cctgcagaaa aggaatgctg acattgctca gattgatgcc 921481 gcagcctgtt ctaacagcag agctgatcga aggtgacgtg attgaattga caaatacaaa 921541 ggcgaaaacc gtgcgcggta ataaagtgat catcggcccg gattgccaga ttgaaaccgt 921601 cgaatacagc ggggactata cctgtgatcc aagcgcgtcg gttgaaacat ccacaaagtt 921661 gtaaggagga tcgtaatgga gacaacaaaa ctgggaaatt taaaattata tggcgctggg 921721 catgccgcag gaggcgcgta tcacaatgtc agcatcaaag gagaaggtat agttggagaa 921781 gggctgtctg ctgtaggctg ccgcatatac ggaacgggcc tttttctcgg aaaagcagag 921841 actgagcggc tgcgtgtgct cggagaaagt gaatgtaaag gcgatctgac agccggcaaa 921901 atcaatatat atgggacaat gaaagtcagc ggctcacttc aatttgatcg attcaatctg 921961 aaaggccaga ctgaaattgg cgggaatatg actggagaat cctgcgatgt gaaagggaag 922021 cttagcgtaa taggtgattg tgaaacagaa atgttccatg tcacaggctg tgttgatgta 922081 tcggggttat taaattcggg tgagatcaag ctgggattga gccatgatat aagccatgtg 922141 caggaaatcg gcggaacaac aattacagtg aaaagacgcg cgagtttttt tagccggaag 922201 aaagggaagc tgatcgccga tgtcatagaa ggagatcggg tttatttgga gaataccgaa 922261 gcggcagttg tcaggggaaa agaagtgatc atcgggccgg gatgcagcat cggaacgatt 922321 gagtacgaat acaaatgtga atgcgatccg cattcacaga ttaaagaaaa aacaaaactg 922381 taaaacattg ttctgttata caaaaagggt gctctttcag gagcaccctt ttttattctt 922441 ttccaggctt gctttcgtat cctgcggtaa aaattgatac taaaaaagtg acaatgacac 922501 ccatcatgat gattgttttc accgtctctc cccctcttca atttttccgt gctgtccgag 922561 tctggatgat tctgtatttt tctttattat gaacggtcgc agtctgcctt gtcaacgatg 922621 tatgagtatc tttattttta agaaaccaaa gcatgtatca cgagatggcg gcatagattg 922681 tatcaaagta ccttatttgc atagtgtatc aaacatgata gaggaggtcc ttatggatat 922741 attaaagaaa attgaaaagt acagagagga agagcagcgg ctgaaatggg aaggaacttt 922801 cgccgattat ttggagatta ttaaagaaaa tccgatggtc gcgcaatctg ctcattctcg 922861 agtttttaat atgataaaag acagcgggat agaggagatt gacggacgca agaagtacag 922921 tttttttgac cgcgagctgt tcgggcttga agaatctctg gagcgtcttg tggaagagta 922981 ttttcatccg gctgccaaac gtctagatgt cagaaagcgg attctattgc tgatggggcc 923041 tgtgagcggc ggtaaatcca cgctggtcac aatgcttaaa aaaggtctcg aagcgtacac 923101 gctgacagat aatggcgctg tatatgcgat taaaggctgc ccgatgcacg aggaccctct 923161 acatttaatc ccccatcatt tacgcgatga cttttacaga gaatacggca ttagaataga 923221 aggaagtctt tctcctttaa atgtcatgag gctggaggaa gagtacggag gaagaattga 923281 ggatgtgaag gtggagcgca tcttcttttc agaagataag cgtacgggaa ttggaacatt 923341 cagtccctct gatccgaaat ctcaggatat tgccgatttg acggggagta ttgatttctc 923401 aacaatcgcc gagtacggtt cagaatcaga tccgcgcgct tatcgatttg acggagagct 923461 gaataaagcg aaccgcggga tgatggagtt tcaggagatg ctgaaatgtg atgagaaatt 923521 tctctggcat ttgctttcct tgacacagga agggaatttt aaagctgggc ggtttgcgtt 923581 aatttctgct gatgagctga tcgtggctca cacgaatgaa acggagtatc gctcatttat 923641 ttctaataag aagaatgaag ccctgcactc aagaatcatc gtgatgccgg ttccttataa 923701 tttaaaagtg tctgaggaag agagaattta tgaaaaaatg attgcagaaa gcgatgtggc 923761 ggatgttcat attgccccgc atacgttgaa ggtcgccgcg atgttctcaa tccttacccg 923821 gttaaaagag ccgaagcggt cggatattga tctggtcaag aaaatgagac tgtatgatgg 923881 ggaaagtgtg gaaggatata actctgtcga cgttgaggat atgaaaaaag aatataatga 923941 tgaaggcatg agcggaattg atccgcggta cgtgatcaac cggatttctt caacgattat 924001 cagaaaaaat atggaatcga ttaattctct cgatgtcctt cgctccttaa aagaaggtct 924061 tgatcagcac ccatcaattt caagcgagga cagggagcgg tatttgaatt ttatctctgc 924121 cgcccgcaag gaatatgacg atattgcgaa aaaggaagtt caaaaagcgt ttgtttattc 924181 atatgaagaa tcagcaaaaa cacttatgga caattacctc gataacgtag aggcctattg 924241 caataaaaac aagcttcgtg atcctttgac aggagaggaa atgaaccctg acgaaaagct 924301 gatgagatcc atcgaagagc agatcggcat ttcggaaaac gccaaaaaag cgttccgcga 924361 agaaatttta atccgcatct cggcctatgc gagaaaaggc aagcggtttg attacaattc 924421 ccatgaaaga ctgcgtgaag ctattcagaa aaagctgttt gctgatctga aggatgtcgt 924481 taaaattacg acctcaacaa aaacgccgga tgagcagcag ctgaaaaagg taaatgaagt 924541 cgtggcccgt ttaattgatg agcacggcta caactcgacg agcgccaatg agctgctgaa 924601 atatgtcggc agcctgctga accgataagc aacgtgaccc gtccgaatag ggcgggttat 924661 tttgtcccat tttctaaata gtttgtcaat taaacgtgca tatgtgcata tgatgaatat 924721 aaatcttttc aaaagacttg tttcataatc tggcacaagc cggaatacgt atgtatcacg 924781 accacaaatg gttaaggagg ggaattcatg tcccaaaatg acagcggcca ttttttgatt 924841 tctgaggaaa actggtccct ccatcgcaaa ggcttcgatg accagcagcg ccaccagaaa 924901 aaagtgcagg aagcgatcaa aaacaatctt ccggacctcg taactgagga aagcattatt 924961 atgtctaatg gaaaagatgt agtgaagatc ccaatccgtt cacttgatga gtataaaatc 925021 cgttataact atgataaaaa taaacatgta gggcaaggag acggcgagag ccaggttgga 925081 gatgttgtgg cccgggatgg atcagacaaa aaacaagggc ctggaaaagg gcagggtgcc 925141 ggtgatcagg caggcgagga ttattatgaa gcggaagttt cattaatgga tttagaagaa 925201 gcgcttttta aagaattaga gcttccgaat ctccagcaaa aagagcggga caatatcatt 925261 catacagata tcgagtttaa tgatatccgt aaaacagggt taaccggtaa tattgataag 925321 aaaagaacga tgatgtcagc ctttaaacga aacgcaatgt caggaaaacc gtcgttctac 925381 ccaatttatc cggaggacct gaaatataag acgtggaatg acatcacaaa gcccgaatca 925441 aaagccgtcg ttttagccat gatggataca agcggcagta tgggggtttg ggaaaaatac 925501 atggccagaa gcttcttttt ctggatgacc cgttttttgc ggacaaaata cgagactgtg 925561 gaaattgaat ttattgccca tcatacagaa gcaagagtgg tctcggagga ggattttttc 925621 tcaaagggag aaagcggcgg aacaatttgt tcttccgtat atcggaagtc gcttgagctt 925681 attgatgaaa agtacaatcc cgcccgctat aacatttacc cgtttcattt ttctgacggt 925741 gacaacctga catctgataa cgcgcgctgt gtgaagctgg tcaatgatat tatgaagaag 925801 gccaatctgt tttgctacgg cgaggtcaat cagtacaaca ggcattcaac gttaatgtct 925861 gcatataaaa atgtaaaaga tgagaaattt aagtactata ttttaaaaca gaaatctgat 925921 gtttttcagg ctctaaagaa ctttttcaga aatgaagagt ctggtgtaag ccatcaattt 925981 tcgtaatgaa aagcccattt cagggctttt ttttatttaa taaaagcaag aaaacgcttg 926041 cgaaaaaaat acgggagaaa aagaaatttt tcctttgaca aatcttcttt catttattaa 926101 tattttatct tgtgaactat tattgaggaa tgaggtgaaa aggagttgac tgaatcagaa 926161 cgtgctttgc tcacttttga acagctcttc gatacgtctc gggcgatata taaaaaacag 926221 aagaagatat tggagattgt gcttgagcct tttgatatta cagtccttca atatttgctg 926281 atgtttaaaa ttcatcaaag cggaagcacc ccgctaagca agctggcaat gtcgcttgat 926341 cttaagcctg cttctgtgac gcggatgaca gatattctgt ataagcgcca attgatgaat 926401 cgatatgaca gtccggatga ccgccgtatc gtcatgattc agttaaccga agagggggaa 926461 gaactgatag aaaaagccgc tgtgcaatat gcaaaaatgg gtgctggctt gtaccaaaag 926521 cttgatacct cccagctgca gtatttgcgc aaactagccg gaagtttaac gaagcttgct 926581 gaaggctgtt cagaaaaaag cggtaattaa aaacttctca catattttca ccagctttcc 926641 gcaaaatgat agaggatgaa acgaaaggag aaaacaaaat gaacagagga cgtttaattc 926701 tgaccaacat tatcggtttg attgttgttc ttgcaattat agctggaggt gcttactact 926761 attatcaaag cacaaactac gtaaaaacag atgaagcaaa agtagcgggc gatatggctg 926821 ctattactgc tccagcagca ggtaaagtat ctgactggga tctggacgaa ggaaaaacag 926881 tgaaaaaagg cgacacagtt gcaaaaatca aaggtgaaca aactgttgac gtaaaatcca 926941 ttatggatgg cacaattgtg aaaaacgaag tgaaaaacgg acaaaccgta caagctggta 927001 caacaattgc acaaacgatt gacatggaca acctatacat cacagcaaat attaaagaaa 927061 cagatattgc ggatattgaa gtaggaaata gtgtagacgt agtagttgac ggagaccctg 927121 atactacatt tgacggtact gtagaagaaa ttggttatgc gactaactca acttttgata 927181 tgcttccttc tacaaattca agcggaaact acacaaaagt aacacaaaaa gttcctgtga 927241 aaatttcaat caaaaaccca tctgataagg tgcttcctgg aatgaatgca tctgttaaaa 927301 tttctgagta aaacagatca gtcatcaaac catgaaagga ggttgtctta gatggctaca 927361 ggcaaagaaa aaaatgcaaa aaaccctatg tcattgctga ttgtgctaat ggcgggttta 927421 tttttggcaa ttctaaacca aacactgctt aatgttgcaa tgccgcactt aatgactgaa 927481 tttggcgtaa gtgcaacgac gattcagtgg ctgacaacag gttacatgct tgttaacggt 927541 gtattgattc cgttatctgc tttcctgatt acacgatttg gccagcggag tctctttctc 927601 gtcgcgatgt tttgttttac gctcggtacg ttagtctgcg gtatcgcacc taacttctct 927661 acaatgctga tcggccgttt gattcaggcc gtgggcggag gtatcttgca gccgctcgtt 927721 atgacaacca ttctgttaat tttcccgcct gaaagcaggg ggaaaggaat ggggattttc 927781 gggctagcga tgatgtttgc tccagcggtc ggcccgactc tttccgggtg gattattgag 927841 cattatacat ggcgcattat gttttacgga cttgtgccga tcggcgcaat tgttatcatt 927901 gtggctttct tcatctttaa aaatatggtg gagccgcaaa aaatcaaact cgatactctt 927961 ggcgcaatcc tctcgattgt cggattcgcc tccttattat acggagtcag tgaagccgga 928021 tctgacggct ggaccgaccc gattgtattg tctacagtta ttatcggagc cattgcaatt 928081 gttgcttttg ttgttcagca attgcgtcat gatgatccga tgcttgattt cagagtgttt 928141 aaatatgaca ttttctcact ctcgagtgtc attaatatca ttattacagt ggcactttac 928201 actggtatgt tccttttacc gatttatctg caaaacctgg tcggctttac ggcgcttcaa 928261 tccggtctgc ttctgcttcc gggtgcgatc gttatgctga ttatgtcacc gatctcaggt 928321 attttgttcg ataaattcgg accgagaccg cttgcgatta tcgggcttct cgtgacagtg 928381 gtaacaacgt atcaatacac gcaattgaca attgatacac catatacaca catcatgctg 928441 atctattcaa ttcgtgcatt tggtatgtct ctcttaatga tgccagtcat gacagccggg 928501 atgaaccagc ttcctgcccg tctgaacagc cacggaacgg cgatgagtaa cacgcttcgc 928561 caaatcagcg gatcaatcgg aacaagttta attacgacga tttatacaaa ccggacgaca 928621 ttccattatt cacaaattgc agataaaaca agcacggcgg acccgaactt cctccatgcg 928681 ttccaaaatg cagtttcgaa tttaatggtg aatatgaatg tgtcttatga tacggcgaaa 928741 acatatgtgt actcacatat ttataaacac gcatcactcg attccaatgt catggggata 928801 aatgatgcct ttatgtgggc aaccttattc tgtgtagcag gtttgatttt aagtatcttc 928861 ctgcgtgacg tcagaaaaga taaattgcgt aagaagaaaa aagaggagct ttcattactt 928921 cctgctccaa aagaagctaa ggaatcttaa tctgtacagg gaggtttcct gaatgaaaat 928981 ttatgtagtg tatgatagtg aaggcgaaca tactaaagtg cttgcagaag cgattgctga 929041 aggcgcgaga gaaaacgacg cggctgaagt gttcatcgac catgtagatc aggctgatat 929101 ccgcaagctt aaagatatgg atgcgattat ttggggatgc ccagggcatt tcggaacaat 929161 cagctccggt cttaaaactt ggatcgacag acttggctac ttgtgggctg aaggcgagct 929221 gatcaacaaa gtcggtgctg tcttctgcac aacggcaaca acacacggcg gcttggaaat 929281 gacaatgcac aatttaatca cgccgatgtt ccaccaaggc atgattgttg tcggactgcc 929341 tggcaacgtg cctgaaaacg cactttatgg ctcttattac ggagcaggtg tcacttgtcc 929401 ggtagacagt gatgagttaa tgtctgagga aggtattcag cttggacgcg cgttgggaag 929461 acgtgtcagc caagtcacag gaaacctaac agcaggacag taaggagagg ttgaaatggc 929521 cattattata gcaataattg ctgctgtcat tgtcattgcg gcccttatta catttaacgt 929581 ccgcaacgcc tcacctggac ctgagaagca agaagcaacc gatagaatcg cacctccaga 929641 agaggaaaaa aacgaagcgc attaccctgc tgaagcaagg gctgccgagc atacgccatc 929701 cgttgtcaaa aacgattctc caaaagagaa gcgtgacaca atgggtgatg atatttacag 929761 gcaggcgctg caaaagttta agcattctga tgaagttcat gcagaagaag aggtcactga 929821 ggaaagtgac aaaatgcagg accgcagcta tcgtgatgcg ctgctctcta tgaaaaataa 929881 gaaaaagtaa tgaaaaaggc aaatccgttt actcatgcgg gtttgccttt tttgctgttt 929941 ccatcaatta tgtttttatc aaataaatcc atggaatatg ttgtattcca ccttgatcta 930001 gtgtactatg ttactcatac accgaggatt ttttccggga ggtaaagaca tgaattcttt 930061 tttaggttta ttaaagaaag atatcaagct ttcaagaatg tggctgctag tatggatatg 930121 cggaatcatt ttcttattgg gaacaggcca tattatagct tctcgcacga aagaacctct 930181 agtcattttt ggtttttttg ttgcagttgc tttttttctg cttttcttat ctcctgtttt 930241 tgttttttat caccttcgca aggaagggaa atcacagctt tggctgtaca atccaaatgg 930301 cggcttatgg ctgttttctt ctaaattggc agcatctttg ctctatcaat ttgtgattca 930361 gttggcatta acagcctatg gcatatggat gtatcatatg ctctctgtaa aaaatctgct 930421 ggagcatcaa gttgatataa cgagtacagt ggctttgctg aatatgtatg ggcttatttc 930481 ttcgttagat atgtcagtaa cagtcattgt gttttggact gtttttcact ctctcagaaa 930541 ttggcgcgga atgcggtggg ctgcgatggt tctgttggtc gcaatgtggt tattcttcga 930601 tgaatacatc ataagccctt tggttgaatc tcaaaagcat ttctggcctg taacagtcta 930661 ttgcaatttt gatttccact tccacaatgt ttggagattg gaactaaaac ctatccatct 930721 gtctgtgcta gggtttccta ttgctatagt catcacattc ttgctgctca tcatggcttc 930781 aaaactgctt gatcgtaaag tagaggtgta aatatggaca atcaattcca atcctcgaaa 930841 ccgatttatc tgcagatcgc tgatcagatc ttttataggc tggtcaggaa ggagctgctc 930901 ccaggagaca agcttccttc agtaagagaa atggcgattc aaactaaagt aaatcccaat 930961 acaattcaaa gaacttacag tgagatggaa aggctgggta ttgtggagac aagaagaggt 931021 caagggacgt ttattgcgga aaaagcagaa atcgtagacg agctgaaaga caagctgaca 931081 cgagaggtgc tggaaggctt tgtcaagcaa atgaaagagc tggggctaac gaaagaagaa 931141 atgttagaag ggattaaaac attcacagag ggaggctaaa atggaaatca agctagaaca 931201 tgtatcaaaa aaatacggcc gccatacggc cgtcaatgat gtgtcaatca ccctatcatc 931261 cggacggatt tatggcctga ttggaccgaa cggcagcggc aagtcaacga ccctgaaaat 931321 gatggctggc cttctgtttc cgacttcagg atttgtaaaa gttgatgaag agcaggttac 931381 gagagaaatg gtgcgtcaaa cggcttatct tactgagctt gatatgtttt atccgcattt 931441 cactgttaaa gatatggtga atttttatca gtcgcagttt cctgattttc atacagaaca 931501 ggtttataag ctattgaatg agatgcagct gaatccggaa aaaaagatca aaaagctatc 931561 aaaaggaaat cggggcaggc tgaaaatcgt tcttgcttta gcgagacggg cagacgtcat 931621 cttgcttgat gaaccttttt ccgggcttga tccgatggtc agggattcca tcgtaaacag 931681 ccttgtgtcg tacattgatt ttgagcagca gattgtcgtg atcgcgacac atgaaattga 931741 tgaaattgag actttgttag atgaagtaat catcctcgcc aatggagaaa aagttgcgca 931801 gcgtgaagta gaagatattc gtgaacagga aggcatgtct gttttgcaat ggtttaaatc 931861 aaaaatggaa gtttgctaga aagaggagga atatgatgaa aacagtgttg gaattgaaaa 931921 acgtgactaa aaacatcaga ggccgaacga tcattgatga tctcagtttt acgattcgtg 931981 aaggcgaggt attcggtttt ttaggaccaa acggagcggg gaaaacgaca accatccgga 932041 tgatggtggg gttaatgaag ctgtcgaaag gtgatgtcct catttgcggc caatcaatta 932101 cgaaagaata tgccaaggcg attaagcata tcggagcgat cgttgagaat cccgagctgt 932161 ataaattttt gagcggatat aaaaatctcc agcaattcgc aaggatggtc aagggtgtca 932221 cgaaggaaaa aattgatgaa gttgttgaac tggtcggttt aacagacaga atccacgaca 932281 aggtgaaaac atattctctg gggatgagac agcgtcttgg cttggcacaa tgccttctgc 932341 acgatccgaa agtgctgatt ttggatgaac cgacaaacgg ccttgatccg gcggggatca 932401 gagaaatcag agatcattta aagaagctga cccgagaaag aggaatggct gtcatcgttt 932461 caagccacct gctgtcagaa atggaactga tgtgtgatcg aattgcgatt ctgcaaaaag 932521 gaaagctgat cgatattcaa aatgtaaaag atgaaaacat tgatgagaat gatacatatt 932581 tcttccaggt tgagcagccg agtgaagccg ctactgtttt aaatcagtac gatttgctga 932641 gtaagacaaa tggtgtagaa atcaaactgg ctaaagagga agtccctgcg gttattgaat 932701 tgctggtgat gcagcaaatc cgtatttatg aggtcaaggt cataacaaaa tcattagagg 932761 accgtttctt agaaatgaca ggtgaaacaa aagaggaggt tcagcatgct taatttgatt 932821 tataatgagt ggctcaaaat tttcagccgt gccggaacat gggtgatgat cggaattctg 932881 gggctgacaa tggttggatt tgcatttttg gcgaatcatt tttctgccgg tgaatcaaat 932941 tcccattgga aacaagagct tcaagcacaa aacgccgaat taaagaaaga aatcaaagaa 933001 gatccttcac tgaaagatgg gtataaagaa acaatcacac tcaatgacta tcgcatcgag 933061 cataatatcc ctagtgacac gggctatacg gtatggtctt atgtaacgga ttcagcaaac 933121 tttaccatcc ttaccggtct gtttactatt atcatcgcgg ccggaattgt cgcgaacgaa 933181 tttaattggg gaacgattaa gctattaatg attcggccgc tcagtcgttt tcaaattttg 933241 atgtccaaat atattacagt tctcctgttt gggctcctgt tgctgttgat tttatttatc 933301 ggttctactt tattagggtt gatcttcttc ggaacgggtg gtgaaaccgc cgcgaatatt 933361 catttaatct ataaggatgg ccatgtcatt gagcaaaaca tgatggggca tttggctaca 933421 acgtatcttt ctgaatccgt ctcggcttta atggtggcga cgatggcgtt tatgctgtct 933481 gcggtattca gaaacagctc tcttgcggtt ggtttttcca tcttcttgtt ggttgccggt 933541 acgactgcaa ctgcatttat tgcagcgaaa tttgactggg caaagtatat attgtttgct 933601 aatgtcgact tgactcagta tgtggatggc acaccgttaa taaaagggat gactatgacg 933661 ttttctctcg tcatgctggc gatctacttt atcatcttcc tgttgcttgc tttcggaatc 933721 ttcatgaagc gggatattgc aaactaataa aaaaagctgt tttgcttatg caaaacagct 933781 tttttgtcaa aataaaaact gcaggtttgc acctgcagtt tttcatatca atttatgctt 933841 acgcttcttt agtaacgtta gcagcttgtg gtccgcggtt tccttcaacg atttcaaaag 933901 aaacagcttg gccttcttct aaagttttga agccttcgcc ttgaatagca gagaaatgaa 933961 cgaatacatc gtcttgacct tctacttcga tgaatccgaa acctttttca gagttgaacc 934021 attttacttt accttctaac atgaaatttc ctcctaaagc gatcataacg cttaaattca 934081 ctattcttgc tcttaacaaa ctttcaagac gaaaactctt acaaaacttt cttcttaaag 934141 atagttcgaa caaaaataat tacctttact ctaccagtaa tcttcagaaa aaacaactgc 934201 ttattgaaat ttttttcgga aaataccata tttatttttc aatttgatat ttatttacgg 934261 aaattcatct gttttctcga tatgtgatca tacgtttgcc ttagtattcc ttcattttgg 934321 gaagataagt aataggaatt gacaacctta ttggatatga gtaaggtaaa agttaatcaa 934381 tattacaaat gacaacgttt atcaactaag agagcgtatg atttttatgt ctgatattgc 934441 ttgcatgctc taatacatag ataggagtat ggtcacaatg aaaaagtggc ttatatgcag 934501 tttcgtcctt gttcttctcg tttcatttac tgcatgttca ccgtctgcag aacatgaatc 934561 gataaaaatc gggattgctg agtctgacgg ggcaatatgg aactatattg ctcaaaaggc 934621 tgaagaggca gggctggata ttcagctgat ccctttttct gattatgcgg agtctgatat 934681 cgcacttgct aacaaagaaa ttgatgccaa cgcctttcaa accatttcat attttcagtc 934741 gttcactgaa aaatacaaac ttaatttggc accgctcggg acgacataca taacgcccat 934801 gggcatttat tcaaaacgat atgaacgaat ccgagatata tcgcggggag ctgtcgtttc 934861 tgttccggat aaagcgttcg attttggcag ggcgcttacg gtgctccagg aagcgggttt 934921 gctaacgctg aaaaacggat ttaacggaac aggttcagtt gatatgatta aagataatcc 934981 gagacacctg aaattaaaag ctgtccggca acaggatgca gtgagcggtg ccgacgtgtt 935041 tgtcatgaaa ccatcagaag caaaaaaagc gggcttgaac ccgaaaaagc atacgctaaa 935101 gagcggcgga ctcatgtctg aggaagagat gaatttgatt gttgtcagag cggaggatca 935161 agatcgggaa gcgctgcaaa ccattcttga gctttatcaa gctgatgata cagcggcatt 935221 tatagaaaaa gaatatcagg gagatcttgt cccggctttt ctgcctttga aacgtctttc 935281 agattggaag aatgaattcg aacattgaat tcattctttt ttttctgaaa aacacactct 935341 gttccgtccc gtttctttcg ctttgtaaag catttgatcg gcaagaatgg gcaaggatcc 935401 tggctgttcc gtattattgg ggtaatgagc ggcccctagt gatatcgtaa ctgaaagctc 935461 gtcgccgttt gttaatacaa tcggtgcatc acttacagtg ctcctgatcc gttcagcgat 935521 ccgggctgct ttatcaagag aacagttcgg caggagcacg gcaaattctt caccgccgat 935581 ccgagcggca ggatcagtat ttcggatggt ctgcttcaga cgtaacccta gctctttgag 935641 cacctgatct ccttcatgat ggccatattg gtcattgatg gtcttaaaat gatcgatatc 935701 catataaatc agtgcaaatt gaaaatgcgg ggtatcggcc gcctgctgat acagagcttt 935761 tgtggtttct tcaaattttc ttcggttata cacgcctgtt aaaaagtcaa agtgcgcctg 935821 aaacttatat tgtttaaaaa gaagatgtgc atttgtttca tgatcaataa tatataaact 935881 gagcatgccg cccgctattg atatgatcca aaaatacaaa tgaagttcgt atgaatgtaa 935941 atctataaga aaataaaagg aaaaggagat caagctattt gtgattatta aaagatagaa 936001 agcatgtttt agttgaactt tttttcttct agaaacaatg agtgacggaa tggcagcgat 936061 acaaatgata ataaccgagt atagtgcaga tgtgttcatc gtaatcagca agcggcctgc 936121 agtgatcatg gccagggccg ttgccgttga aacccagcct ccataaagag cggcaatcat 936181 aatagggata tttcgaagat caataattga atgctgatag gtaaatccaa aaaccatcag 936241 aataaccccg agcaaaccgc aggccagtcc tttaacagct tgaaaggata tgctgtcttt 936301 tttatgtact agcctttctt taaacaggtg ggtgaagaga taattaaatg tgattaaaat 936361 ggtcaaattt acaaacagtt ctttcagcaa atattatcac ccttatataa ggtactaaag 936421 atggaaggga aagaaaagaa caaaaaaggc attatataag gtttttttac ttgaattgat 936481 aagttaaaat aattcgcact tgacccatcg gaattagtgt aatatagtaa atgagaaaat 936541 ttgaagggag agtttacctg ctttggagac tttactggtt gtattacatg tatttatttt 936601 atttttactt atcttagggc tctttgttat gcagaaaaaa catgtttcct tctctaaacg 936661 tgtatttact gcgctggggc tggggattgt attcggattt gcgcttcagc tgatttacgg 936721 cccgacttca aatatagtca ttcaaacagc cgactggttt aatattgccg ggggcggata 936781 tgtcaaattg cttcagatgg ttgtcatgcc gctcgtcttt atttcgattc tcggcgcctt 936841 tacaaagctg aagctgacaa aaaatcttgg gaaaatcagc ggtttgatta tcgggatttt 936901 agtagcaaca acagcagttg ctgcagctgt cggtatcgcg tccgcgcttt catttgatct 936961 gcaggcgatt caggttgacc aaggaagtac agagctttca cggggacagg agcttcagca 937021 gaaatcagag gatatgacag cgaaaacgct gccgcagcag attgttgaac tgctgcctgg 937081 aaacccgttt ttagatttta cgggagctag accgacttca acgatcgctg tcgttatttt 937141 tgccgctttc cttggagtgg cattcctcgg cgtaaaacac aaacagccgg aacaggcaga 937201 aacatttaaa aaactggttg atgccgttta tgccattgtc atgcgtgttg tcacactcat 937261 tttgagactg acgccttatg gggtgctggc catcatgaca aaaacaattg caacgagtga 937321 tcttgacagc attctaaaac tgggcatgtt cgtgattgca tcatatgccg cgttaatcac 937381 tatgtttatc attcatttgc tgctgctgac gttcagcggc ttgaatccgg tgatttattt 937441 gaaaaaagcg gtgcctgtac ttgtatttgc atttacgtca aggtctagcg caggtgcttt 937501 accgctgaat attaaaacac agagaagcat gggtgtaccg gagggaatcg caaactttgc 937561 cggttcgttc ggtctttcga tcggccaaaa tggatgtgcc ggcatttatc ctgcgatgct 937621 ggcgatgatg attgctccga ctgtcggcca aaatccattt gacccggtgt ttattatcac 937681 tgttatcgca gtcgttgcca tcagctcctt cggggttgcc ggagtcggcg gcggagcgac 937741 attcgcggcg cttcttgttt tatcatcatt aaacatgcct gtcgcgctcg ccggtttgtt 937801 aatctcaatt gaaccgttaa tcgacatggg gcgtactgct ttgaatgtca gcggaagcat 937861 gacatccggt cttattacaa gtaaggtcac aaaagaaatt gatcaagggg catttcatga 937921 tcaatccaga gtgattgaag ctgaagaagc gtaacatatg aaaacgtgta atccaagagg 937981 attacacgtt tttttaacgg ccaggctcta agtcctccag catttccatc atcgtgttgt 938041 cgtccatgac attcattgcg ttttgttcaa aatgaatggg ttcagcataa tgcggctgtc 938101 tttttttcgc ggctgtctca gtttgcctag tttgagactg tgtatgctga tgctgtggtt 938161 gctgctgtcc agcgtgctgg tgctgacggc cattttgccg ctggctttga tgctgcgaac 938221 ggtcctggtt atcaccgctg cttccgctgc ttccgctaaa tgcttgtttg accatgtttc 938281 ctacattaga agcatcaaac gtgttatttt ctgaatttcg tctgttcatt tgtcctgtga 938341 taaacccgct gattctttgg cggatctgag gtgataatgc agtaataagc atagttgatc 938401 ctatgatcaa tgctgcgggg ctgattcctc ttcgctggtt gaacaacatg atccctcctt 938461 tgcagtgtat tcatattttc cccctcgtta gacaaattaa ccgttatatt tcccgggaaa 938521 gcatttcctc cagatttgca tgcataatta aagccagtta gaaaaaccta taagtaaagt 938581 gataaaggag gaattcacat gtttggaaaa aaacaagtcc ttgcgtctgt gcttcttatc 938641 cctttgctta tgactggctg cggtgtagcc gaccaaggtg agggcagacg tgataataat 938701 gatgtaagaa acgtaaatta tcgaaatccg gccaatgacg atatgcggaa tgtaaacaat 938761 cgggataacg ttgacaacaa tgttaatgat aatgtcaata acaatcgtgt aaatgacgat 938821 aataacaacg accgaaaact tgaggttgct gatgaagcag ctgataaagt aacagaccta 938881 aaagaagtaa agcatgccga tatcattgtg gctggaaatc aagcctacgt tgcagtcgtt 938941 ttaaccaatg gaaataaagg tgcagtagaa aacaatctga agaaaaaaat agccaaaaag 939001 gtaagatcta ctgacaaaaa cattgataat gtttacgttt cagctaaccc tgattttgta 939061 gagcgtatgc aaggatatgg aaagcgtatt caaaatggtg acccaatcgc cggattattt 939121 gatgaattta cacaaactgt acagcgtgta ttccctaacg ctgaataaat gaaagaagcc 939181 gcacaatttg tgcggctttt tctttgcgtt aatgacacac tgcgaactca ggctgcatag 939241 agtaaaaata aaaaggtaca agacggaccg gctcagggag ggagacgttt gcgggatggc 939301 ataggaaagc gtgcggcatc cgctctattc ctgtgcggag tccttgtgat gctggctgta 939361 agctcagcca tcgtatcaag cgcgatgtat atcctgtctt ttccaggtca ggcatctgga 939421 ataacaaaag aacaagtgac gaagcacatg aagaaagagt cattcaaaca ggccgatatt 939481 tattacactt ctaaggaaaa gtccttactg ccattgacga aagaaacgct tgaatatgcg 939541 gtcagtatta atcagattat gattggatat tcgaatcaaa agcctattga cattattttt 939601 tttcctaatg aaaaacagat ggaggcttac tccggtttat tggatgtagt tggtttttat 939661 tctgaacggg agcagctgat cggattgttg cctgaagaga aaaagaaact gttagaaggg 939721 gacgaggtag cggtttattt gtaccagaga ttgttgattc atgaatactc gcaccatgcg 939781 tttcaccaga aattgaagga gcttgagacg gatcccgatg agtttccgtt atggtttcat 939841 gaagggttaa gcgagtggat tgcgaactat gaattgctca tagatccgat cacgttttct 939901 gtcgtgccct ttgaccgttt gcagactgat cgagactggc aggaagctag agccgaatat 939961 gacactgatg tctatttgca aagcttttat atgatcgatg agctgacgga caaatacggg 940021 aaagacatta tttcagaaat gattaaggaa acggcaaaaa aaggggactt tgaaaaaggg 940081 tttaaatcag caacaaagga aagtcttgat caatttgaaa aagattttaa gaaaaaattt 940141 gaaaaaaaca gtgcggcatt ggatagtatc tatccaatgc ctttgttatt agtgaagtcc 940201 ttgctgaccc attccgcctt gtgtcggagg catttgtcct tgggcagggg cgaatgaatt 940261 tcgcagctgt tccatatcct gcgcatcaag ctgaggaacc tggtaatagc cgtgtttgtt 940321 ttggtatagg aaaatttcaa atgccatttc aacatactcc tgaatttgcg cagacagtac 940381 gcgtcttacg gccggatttg tcatttccag agaagccatc gtcagcatag aagcttgtgc 940441 tttaatcgcg caaagcattt gtcggctgat gatgctgtca tcaatatcat tcatggattg 940501 aacaggtttt ttaggctgtg acggctgcat gccgtaaaca gtctggttgt cttccttcat 940561 catataagtt gctgtttttt gtgaaggttc gcttcctgtt ttgaagcatt ctgcagttat 940621 attgtattga gatgtgatga attgatgttg acgatcaagg atgtttagta attcttgatc 940681 cttacagaat tgtctcagca tcataaactg atcaagcaca gtaagtgttc cggaaagcac 940741 ctcatgcata tcaaacattt catgtccgcc gtggttttta tgcggtttgc caggaatacc 940801 tttgttcatt tgggattgct gctgctgatt gaactgatcc aaaccgaatt cctccttttt 940861 tttcagatca gctgtatttt gtgtcagtct gccgtgtatt atgcagaagc ctgaaaggaa 940921 ttatatgctg tctgtcgaaa tgataagcag acaaaatcgt tgtcattatg tgtataaggg 940981 aggaaatatg atgaggcgta ttctgcatat tgtgttgatc acggcattaa tgttcttaaa 941041 tgtaatgtac acgttcgaag ctgtaaaggc agctgaaccg caacagccta tatcgattga 941101 gaaggcaata cagcaaaaag aaggacaggc acttgtcgaa ggatatgcag tcggccaggc 941161 tgtttccccg cagcattata aactgacaag ccctttttca aatgattata atgttgcgct 941221 ggcagaccgt aaaaacaaaa catcgcccga acacatcctt cctgtgcaaa tcccctccgc 941281 cttcagaagc caatttgggc tgcaaaccaa tccgcttctt cttgggaaaa agataacggt 941341 tcaaggaaag cttgaaaatt actttaacac gacaggactt aaaaacgttc agtcgatgaa 941401 cgtaaccgat gacacaaaaa ctccgccggc tgaacagcaa gtgaccataa atgaagcacg 941461 gggaaggctg aatgaagaag taacgataaa agggatcatt acagctgatc aaaacgcaat 941521 cggaggcggg aagctgtcga cctttttgca agatgaaacc ggaggcatta acatttattc 941581 gccatcccct gaacaatttc ccgaattaaa agagggtatg gatgtcacgg tgacagggaa 941641 aatcacgtct taccaggggc tgaaagaaat cgttccaaac tcatcaggca tcaaaatcaa 941701 ccagtcaaat caatccctcc ccgcccccaa acacttaaca atcaatgaac ttattaacgg 941761 cagcctaggt gatcagtatg aaggacgcct tgtgaaacta accgcttttg tttcctcaat 941821 tccaagttct cctgccggcg gcggttacaa tgtaacaatg attgatgacg accatcatgc 941881 aatgacgctc cgggttatga atgaaacagg ggtgataaac gagcttgatg agggcaaatg 941941 gtatgaattt accggtgtgt taagcagata ccaaaccttt cagctgcttc cgcgaaaatc 942001 ggctgacctg aagctgcttg aagagcagcc cgcacctccg tctgcagagg gagaatatga 942061 agggattgtt gaccgggtag ttgacggcga taccattcat cttaaatctc cggtgcttgg 942121 aacgacaaaa atccggtttg taaatgtaga tgcacccgaa acatatcaca caccaaaaaa 942181 tgacgcagat gaaaatcaat taagatttgg caaaaaagca tctgactatc taaaaacggt 942241 tctgtccccg ggtgataaaa ttactgtcaa ggtcgggagt gaagccaagg acagctatgg 942301 cagattgctc ggacaagtca taaccgaatc aggttcaaac gtgaacttag agcttgtaaa 942361 aaacggctat gctccgacgt attttatttg gccggttgac aatgaagagg attatcagca 942421 atttcaggcc gcagtagccg ctgcaaaaaa agatcaaaaa ggaatttgga atgaaaacga 942481 tcccctcatg gaaatgccgt ttgaattcag agccagagag caagggaaag gcctgacaag 942541 atatgtgggg gactcgtcga ataaaacata tgtgcagcca gctgactgga agaagatagc 942601 tgtggaaaac agaattttct tcgcctcagc aagtgaagcg gagagcgcgg gatataaaaa 942661 aaggcaaacg gcacctcaag aacatgtgcc gcttagaatt ctcagcatga atgatttgca 942721 tggcaaaatc gatcagcaat atgagcttga tcttgatgga aatggaactg tagacggcac 942781 gtttggacgc atggattatg ccgccgcata tttaaaagaa aaaaaggctg aaaagaaaaa 942841 ctcgctgatt gtgcacgcgg gagatatgat cggcggaagc tctccagttt cctctcttct 942901 tcaggatgaa ccgactgtag aactgatgga ggacatcgga tttgatgtcg gaaccgtggg 942961 aaaccacgaa tttgatgaag gcacggatga acttctgagg atcttaaatg gcggtgatca 943021 tccgaaaggc acaagcggat atgatggaca gaactttccc cttgtatgtg ccaattgtaa 943081 aatgaaatca actggagagc cctttttgcc ggcttacgac atcattaatg tggagggcgt 943141 acccgttgct tttatcggag ttgtcacaca gtcggcagct ggcatggtta tgcctgaagg 943201 aataaaaaat atcgagttta cagatgaagc aacagcggtg aataaggcgg ccgaagagct 943261 caagaaaaaa ggcgtgaagg ccatcgcggt tctcgcacat atgtcagctg aacaaaacgg 943321 caacgccatt accggtgagt ctgctgatct tgcaaacaaa acagattctg aaattgacgt 943381 gatttttgcc gcgcataatc atcaggttgt taacggtgaa gtgaatggaa aactgattgt 943441 tcaagcgttt gaatatggaa aagcgatagg tgtcgttgat gtagagatcg ataaaacgac 943501 aaaagacatt gtcaaaaagt ccgcggaaat cgtatatgtt gatcaaagta aaatcgaacc 943561 ggatgtcagc gcgtcagcca ttttaaagaa atacgaaaca attgcggaac cgattatcag 943621 cgaggtagtc ggcgaagccg ctgttgatat ggaagggggg tattcaaatg acggcgatac 943681 acctcttgga aacctgattg cggatggtat gagagctgcc atgaaaacgg attttgccct 943741 tatgaatggc ggcggcatac gtgaagcgct gaagaagggt ccaattacgt ggggagatct 943801 ttacaatatt cagccgtttg gaaatgtgtt aacgaagctt gagattaaag gaaaagattt 943861 aagagagatt atcaatgcgc aaatctcgcc ggtttttggg cctgactaca gcatcagcgg 943921 gtttacgtat acgtgggata aagaaaccgg aaaagcagtt gatatgaaaa tggcagatgg 943981 caccgagatc cagcccgatg ccacatatac attgaccgtc aacaacttta tggcgacggc 944041 gacaggagcc aaatatcagc caatcggact gctgggaaaa aatccggtga cagggcctga 944101 ggatttggaa gcgacagttg agtacgtgaa gagttttgat gagccaattg cgtatacaaa 944161 agagggaaga attaagcttg ctgaagccag tgatattgaa gaccctgtaa cagaagaccc 944221 gataacggaa gagcctggag atgatccggg gacggaggat ccgattaaag aggatccaag 944281 gccaggtgaa gatttgcctg atataaaaga aactccggga acagcaccgg ttcatcagct 944341 tccgccttca gccatttcga gattcaatga aataccaatc aacaacacaa aaaccgctga 944401 tactgctaat agcatcagca cattgccgtt acaaaccgag actgcggaaa gcgggtctga 944461 tcatcagctt ccggatacgt cagcgggcta ctataacttt atggtaatcg gtgcggcggt 944521 gacattgtca ggaacttatc tatatgtcag aagaaaaagg agcgcctcca gaacgtgaaa 944581 aaagttattc cactattcat cattgctgcc ggcctagtga tcgcaggcta tggaggcttt 944641 aaattgatcg atacgaatac gaaaacggaa cagacattaa aagaagcaaa gctggcggct 944701 aaaaagccgc aggaagcttc ggggacgaaa aatagcacag atcaagcaaa gaacaaagca 944761 tcatttaagc ctgagaccgg ccaagcgagc ggcattttag aaataccgaa aatcaatgca 944821 gagcttccga tcgtggaggg caccgatgct gatgatttag aaaaaggtgt cgggcattac 944881 aaggacagct attatcctga tgaaaacgga caaattgtgc tgtcagggca tcgggatacc 944941 gtgtttcgcc ggacgggaga gctggaaaag ggggatcagc tccgtcttct cctgtcatat 945001 ggagaattca catatgaaat tgtaaaaaca aaaattgtcg ataaggatga cacatctatt 945061 atcacgctcc agcatgaaaa ggaagagctg attctgacga cctgctatcc gttttcatac 945121 gtcggaaatg ccccgaagcg ctatattata tatggaaaac gagtgactta aaaagccgag 945181 gcagtgcctg cggcttttct tcatgaaaaa tatgtgcggc aaaggttttt catatcagca 945241 gggaaagggg cttcagcaac tatgagctcg tctgttatcg ggtgaaccgc ttgtacttta 945301 ttggcgtgca gtgcctgcct gtttagcagc ttgctcccgc ctccgtaaag cgagtctcct 945361 gtcaacggat ggccgaggct cgccagatga acacggattt ggtgtgttct gcctgtttcc 945421 agctctaatt caacgagcga cagccgttct ttcgcattgc tggccattac cttgaaatga 945481 gtgacggctg tttgcccgcc tggtgaaacc cggcgtcttg tcgggtgtga gcggtctctg 945541 ccgatcggtg aattaattgt cccttttttc gtccgtagct taccttcagc gatagcggta 945601 tacgtacgct tcagcgtctt tttctctaac tgctggtcta agatggcgtg tgccaaacga 945661 tgcttggcaa aaacgatagc gccagatgta tcctgatcaa gacgatggac gtggcgcacc 945721 ttacatgttt cgccatttat ctgataatga tacgcgatca aattagccag tgtgccggtt 945781 tgcccatcct cattcggatg cgtcgcgatg ccagcgggtt tattgatgat gagcatatga 945841 ttgtcctcaa ataaaatatc aagctcgcca tactccggaa tgaccgaaga tgcttcactt 945901 tcctgaagat caatgaacac gcggtctccc ttttttacaa tcatattgtt taagacggat 945961 tcgtgattga cctttatctg ttgatgggac atccagtctt gtatcactgg tttagaagct 946021 ttgagcgctg ttttgagtac ggaaaacagc cattggccgt cctgtttttc attgatgagg 946081 atctcaagcc ctctgccttt ttggttcatg ttaaatggct ccttttcgaa gcggaaggct 946141 gctgtttctc ataggaaaca cttaccttag ctttcgcgtt tttttctgtg ctattcttga 946201 gtaagactta ggatattcga tggcaagaaa ggtgattgac gtgagaattg tgaacgcagc 946261 aactgcagaa caggagagct ttatcaagga gctgtctatg gagctgatcc atgatgtatt 946321 tcctctttat ttctccgaac tggacattca gcgctttaaa aagaaaggcg ttctgtcttt 946381 aaataaccat tattaccaag gaacattaaa agaagcattt caaattatgg cttgtctgca 946441 aatgatacat attatcctga ccaagccttc gccgcactct gatttgagtg atcaggcgat 946501 ttttgaaaaa aacagcaaga tgctgaatga ttttgggatt tattttccgt ttgctttttc 946561 tgactttcaa aagaagacta acaaagcctt tttcggtcaa agaaggctga tataatcatg 946621 cggcaagggc ttttctattt ttagaaaagc tctttttgta tcagagaaat catatcataa 946681 aacctttcct ctaactccct ttttaaacgg ctcgtgtctg aacatactaa tgattgaaag 946741 gggtgctgac aatgagttca gttaaagata caatgacaac gcaggtggca accgtttctc 946801 cgaatcaaac gattcaggaa gcggcttctc taatgaaaca gcataacgtc ggggcgatcc 946861 ccgttgtaga gcaaggtgtt ttaaaaggaa tgctgactga ccgtgacatt gcattaagaa 946921 ctacagctca gggccgtgat ggccagacac ccgtttcaga agtgatgtca acagaactcg 946981 tatcaggaaa ccctaatatg agtctggaag acgcgtcgca gctgatggcc cagcaccaaa 947041 tccgccgcct tcctattgta gatcaaaaca atctagtcgg gatcgttgcg cttggagacc 947101 tggcagtcaa tcagatgtcg aacgagtctg cgggatcagc gctgacaaac atttctcacc 947161 aaaacattca ttaataagaa agagcttgca gtgtgcaggc tctttcttca cataaaacct 947221 tactttttga aagcagactt gtttcggggt atagtgagtg tatacatatg tctcaattcg 947281 tactaaagga gttgtaccca gtgattaaag cgttaatttt tgattttgac gggcttattc 947341 tagatacaga aacacacgaa tatgaggttc ttcaggaaat atttgaagag cacggctcag 947401 tgctgccgct atctgtctgg ggaaaggtca tcggaactgc tgcgggtttc cggccttttg 947461 aatatttaga agagcagatc gggaaaaagc tgaaccatga agagctcaca caattgagaa 947521 gagagcggtt tgccaaacgc atggaatcag aaaaagcgag acctggtgtc gaagcgtatt 947581 tgaatgcggc aaaggattta ggcttaaaaa taggccttgc ctccagctct gattataaat 947641 gggtgtccgg ccatttgaag caaatcggcc tgtttgatga ttttgaagtt attcaaacgg 947701 cggatgatgt ggaagaggtg aagccgaatc ctgaactcta tttattggcg gcaaagaacc 947761 tgggggtatc gccagcggaa tgtctcgcgt ttgaggattc tgtcaatggt tcgattgctg 947821 cgaaacgtgc aggcatgaag tgtgtcattg tcccgaataa agtaacgggt accttgatgt 947881 ttgaagacta tgatcacagg cttgaatcaa tggcggagat ggagctcgcc ctattgcttg 947941 atcatctgaa ctcacaaaac tagaaaggag cgagtaggtt gtctgagaaa ttagatttga 948001 cccggtttga aaagaaaatg gttatccgca atatcgaaga gaaagacatc gacaagatta 948061 tcgatcttca aaaggactgc tttccaggaa tggagccttg gaagcgggag catttaatca 948121 gccatttgga gcattttccg gaaggacagt tttgtgcaga attcgaaggt gaaattatcg 948181 gttcgtgctc aagtctcctg attaactttg atgaatatga tgaccgccat acgtggcagg 948241 acattacaga tgacggttat atcaccaacc ataatcctga cggcttgaat atgtacggaa 948301 ttgaagtcat ggtgcacccg aaatacagac gaatgaagat cggccaccgt ttgtacgagg 948361 cgagaaagga cttagccaga cgcttaaacc tgaaaagcat catcataggc ggacggattc 948421 caaactatca caaatatgca gaggaaatga cagcgagaga gtatgttgaa caggtgacac 948481 gccaccaaat ttacgatccg gttctttctt ttcagctgat gaacggcttt acccttatgc 948541 gaattaaccc gaactatctc ccggatgata cagcttcgat caagtatgcg acgctgatgg 948601 aatggaataa tgtcgattat ctaccgcagc agacaaaacg ctattataaa tcggcgttcc 948661 ctgttagaat ttgtgtgatc caatacgaaa tgaagaaaat ttattccttt gaggaatttg 948721 cgaatcaagt agaatactat gtcgatgttg cttccgacgc aagatctgat tttgcggtgt 948781 tcccggaaat tttcacaacc cagctgatgt ccttccttga ggaacggtca ccgagcttgg 948841 cggtgcagag aattaccgag tatacagaag attacatcag cctgtttact gacttggctg 948901 tgaagtataa cgtcaacatt atcggcggat ctcatttcgt cgaagaggaa ggcaagatct 948961 ataatatcgc ttacctgttc agacgggacg gaacgatcga gaagcaatac aaactccata 949021 ttacgccgaa tgaacgcaaa tggtggggga tcagcgcagg agaccaagtt cgcgtgtttg 949081 atacggactg cgggaaaatc gcgatccaga tctgttatga cattgaattt cctgagcttg 949141 cccggattgc ggctgataaa ggagccaaaa tcatctttac gccattttgt acagaagacc 949201 gtcaaggcta tctgcgtgtc agatactgtt cgcaggctag agcggttgaa aatcaaattt 949261 atacggttat ctctggaacg gtcggaaacc ttccgcaaac ggaaaacatg gatatccaat 949321 acgcccagtc aggcatcttt gccccgtctg attttgaatt cgcccgagac ggcattgtcg 949381 gcgaaacaaa cccgaatatt gaaatggtcg tcatcggcga tgttgacctg gaaattctca 949441 gaagacagcg ccaaaacggt acagtgcgcc agctaaaaga cagacgacgt gatatttatc 949501 atattcaata taaaaaataa ttcccaaaaa acccgcctga attggcgggt ttttttaaac 949561 aaaagcggaa ttgtttaggt gctttcttta aaataaaagt aaattgtata gtggatgtgc 949621 cttatggagt ttctgtattt tcgccatttc ctatatcata cagaaaacgg ctaggcttca 949681 cattgctatt gcaatggctg tccaagttgt ttcgagtgcg acctttatca gtacgatgct 949741 gagcattgtc actttgcctg ttttgctttg gaagctgcat cctctttctt cttgagaaag 949801 gggatgtttt attatttacg cggtttattg actctgaccc ggtctggctt tatattgaag 949861 gcagggaaat catcaccaag acatcacata aagagaaggt ctgtttcaat tgaattggca 949921 ttatagggaa cgctaatgaa atggagatga tggggatgga aaacattcag caaaatcagg 949981 gattaaagca aaaagatgag caatttgtgt ggcatgccat gaagggagcg catcaagcgg 950041 acagcctgat agcccagaag gccgaagggg cctgggtaac cgacacagac ggacgccgct 950101 atttggatgc gatgtccggt ttgtggtgcg tcaacattgg ttacggcaga aaggagcttg 950161 cggaggctgc ctatgagcaa ctaaaggagc tgccttacta cccgttaacg caaagtcacg 950221 cacccgcaat tcaactggcg gaaaagctga atgaatggct tggcggcgat tatgttattt 950281 ttttttccaa cagcggatcg gaagcaaacg aaactgcttt taaaattgcc cgccagtacc 950341 atctgcaaaa cggcgaccac agccgttata aattcatctc aagatatcgg gcataccacg 950401 gcaatacatt gggagcgctc tcagctaccg gacaggcgca gcggaaatat aaatacgagc 950461 ctttgagcca agggttcctg catgcagctc cgccagatat ataccggaat cctgatgatg 950521 cagacacgct tgaaagcgca aatgaaatcg accgcatcat gacatgggaa ttaagcgaaa 950581 cgattgccgg ggtcattatg gagcccatca ttacaggcgg aggcatccta atgccgccgg 950641 acggatatat gaagaaggtg gaggacattt gccggcgcca cggagccctt ttgatttgcg 950701 atgaagtgat ctgcgggttt ggacggacag gtgagccgtt cgggtttatg cactacggtg 950761 tgaagcctga tatcattacg atggcaaagg gaatcacaag cgcgtatctg ccattgtcag 950821 cgactgctgt gaaacgggac attttcgaag cgtatcaggg ggaagctcct tatgaccgtt 950881 tccgccacgt gaacacgttc ggcggaagcc cggctgcctg tgctttggcg ttgaaaaacc 950941 tgcaaattat ggaggacgaa cagctgattc agcgatcccg tgatcttgga gcaaagcttt 951001 taggtgagct tcaagctctg agagaacacc cggcagtcgg ggatgttaga ggaaaagggc 951061 tgctgatcgg aatcgaactc gtcaaagaca aattgactaa agagccggct gatgccgcca 951121 aagtaaacca agtggttgcg gcgtgcaaag aaaaagggct gatcatcggc aaaaacggcg 951181 atacagtcgc cggctacaac aatgtcatcc agcttgcgcc gccattttgc ctgacagaag 951241 aggacctttc ctttatcgtg aaaacggtga aagaaagctt tcaaacgata taatataaaa 951301 gtgaattatt aaaggagcac atgatgagtt ttcacaacca gccgatctta ccggctattc 951361 gcaatatgaa gcaatttgat gagtttttga acagttcatt ctcttacggt gttattcttg 951421 atattcatct cggccagctg aagggcgtga tcaaagaagc gcaaaagcac ggaaagaaca 951481 tgatggtgca cgtcgatctc attcaaggga ttaagcatga cgaatacggt gcggaattta 951541 tatgtcagga tatcaagccc gctgggatta tttccacaag atcgaatgtg attgccaaag 951601 cgaagcagaa gaaaatttat gccattcagc gcctgttttt gcttgataca agcgcgatgg 951661 agaaaagcat ggagtttatc ggcaagcata agcctgactt catcgaagtg cttcccggca 951721 tcgttccgtc actcattcag gaaataaaag agaaaacagg gattcccatc tttgccgggg 951781 gtttcatccg tacggaagag gatgtagagc aggcattgaa agcgggggct gtagctgtca 951841 caacatctaa taccaaattg tggaaaaaat atgaaaactt tttgacggaa agtgattgac 951901 accgctttca tgcactgata caattgcact aggttaatac attgtgatgg agaactcgga 951961 gaccacagca gctctttacg gcaaatgttt atgcacccgt aaagcggttt gttgtggttt 952021 ttttattctc ttcttctcta tcatgctttt taatcgtgac tttaggagga atgtgctatg 952081 acagcatttt ggggagaagt catcggtacg atgctgctta tcatttttgg tgcaggtgtt 952141 tgtgcaggtg tcaatttaaa gaaatcgctt tcattccagt ctggctggat tgttgttgta 952201 tttggatggg gattgggtgt tgccatggcg gcatacgcgg ttggcggcat cagcggtgcc 952261 catttgaatc cggcgctaac gatagcgctt gcatttgtag gagattttcc ttggaaagag 952321 gttccggttt atattgcggc gcaaatgatc ggagcgatca tcggtgcggt gattatttat 952381 ctgcattacc tcccgcactg gaagtcaacg gatgatcccg ctgccaagct gggtgttttc 952441 tcaacagggc ccagcattcc gcatacattt gcaaacgttt taagcgaagt gattgggaca 952501 tttgtccttg tacttggaat cttggccata ggtgcaaatc aatttacaga aggacttaat 952561 cctttaatcg tcggtttcct cattgtagca atcggtattt ctctgggagg caccaccggc 952621 tatgctatca atcctgcacg tgacttaggt ccgcggatcg cccacgcttt tcttccgatt 952681 ccggggaagg gctcatcaaa ctggaaatac gcatgggttc cggtagtcgg cccgatttta 952741 ggcggatcat tcggcggtgt attttacaac gctgcattta aagggcacat cacaagcagc 952801 ttctggattg taagcgttat attggttgtg gtattgttag gactctatgt ttatacgaaa 952861 tcacattctg ctaaaacatt atcaaattct aaatatattt aatcaaaggg gagacatctt 952921 atggaaacgt acattttatc cttagatcag gggacgacaa gttcaagagc gattctgttt 952981 aataaagaag gcaaaattgt ccactctgct caaaaggaat ttacacaata cttcccgcat 953041 cctggctggg ttgagcataa tgccaatgaa atttggggct ctgtcctcgc ggttatcgcc 953101 tcagtcatct ctgaatcagg aatcagcgct tctcaaattg ccggcatcgg catcacgaac 953161 cagcgcgaga cgacggttgt gtgggataaa gatacaggaa gtcctgtcta taatgcaatc 953221 gtttggcagt ccagacagac gtccggcatt tgtgaggaac ttcgtgaaaa aggatataat 953281 gataaattca gagaaaaaac agggctttta atcgatcctt acttctccgg cacgaaggtg 953341 aagtggattt tagacaatgt ggaaggcgca agagaaaaag cggaaaaagg cgagctgctg 953401 tttggaacga ttgatacgtg gctcatttgg aaaatgtcag gcggaaaagc gcatgtgacc 953461 gattactcca atgcctcaag aacactgatg tttaatattt acgatttaaa atgggacgat 953521 gaactgctcg acattctagg cgtaccgaaa tccatgctcc ctgaagtgaa gccgtcctct 953581 catgtgtatg cggagactgt tgattatcac ttcttcggaa aaaatatccc gattgctgga 953641 gcggcaggcg accagcagtc cgcattgttc ggccaggcat gctttgaaga aggcatgggg 953701 aaaaacactt acggcacagg atgtttcatg ctgatgaata ccggggaaaa agcaattaag 953761 tccgaacatg ggcttttgac aacaatcgct tggggcattg acggaaaagt gaactatgcg 953821 ttagaaggga gcatttttgt cgcaggctct gccatccagt ggcttagaga cggtttgaga 953881 atgttccagg attcatcgct aagcgaatct tatgcagaaa aagtggattc aactgacggc 953941 gtgtatgttg ttccagcatt tgtcggactg ggaacgcctt actgggacag cgatgtgcgc 954001 ggttcggttt tcggcctgac aagagggaca acaaaagagc actttatccg tgcgacactg 954061 gagtcattgg cttatcagac caaagatgtg cttgacgcaa tggaagcaga ttcaaacatt 954121 tcattaaaga cgctccgtgt agacggagga gctgtaaaaa acaatttcct aatgcagttc 954181 caaggagacc tgttgaatgt tcctgtggag cgcccggaaa ttaatgaaac gactgcactt 954241 ggcgcggctt atttggcggg tatcgctgtg ggattctgga aggaccgttc tgaaatcgcg 954301 aaccagtgga atctggataa acggtttgag cctgaattgg aagaagaaaa acgaaatgag 954361 ctgtataaag gctggcaaaa agccgtgaaa gcagctatgg cttttaaata aagtaatact 954421 atggtataat ggttacaagt taataagaac ggtcctgaga tgaggagaga ccacagcacc 954481 aaagtgtaag catgcacttt ggctgttgtg gtctcttttt ctatttaccg tgacaacaag 954541 gaggaaacgt aatgatgaat catcaatttt caagtcttga aagagatcgc atgctgacag 954601 acatgacgaa aaaaacatat gacctattta ttatcggagg aggaattaca ggagccggaa 954661 cagctcttga cgcggcatca aggggaatga aggtcgcact aagcgaaatg caggactttg 954721 cggcgggaac atcaagccga tcaacgaagc tggtacatgg cggcttgcgc tatttaaaac 954781 aatttgaagt gaaaatggtc gctgaggtag gaaaagagcg ggcgattgtg tatgaaaacg 954841 gcccgcatgt cactacaccg gaatggatgc tgcttccgtt tcataaaggc ggcacattcg 954901 gttcatttac aacatctatt gggttaaggg tttatgactt ccttgcaggt gtgaaaaagt 954961 cagaacgaag aagcatgctt tcagcaaaag aaacgctgca aaaagagcct ttggtgaaaa 955021 aagacggctt aaaaggcggc gggtactatg tggaataccg cactgacgat gcgagactga 955081 ccatcgaagt catgaaggaa gcggttaaat tcggggcaga gcctgtgaat tactccaaag 955141 tgaaggagct tctttacgaa aaaggcaaag ccgtcggcgt attaattgaa gatgtgctga 955201 caaagaaaga atataaagtg tatgcgaaaa aaattgtcaa tgctacaggc ccttgggtcg 955261 atcagctcag agaaaaagac cattcgaaaa acggaaagca tttgcagcat acaaaaggca 955321 ttcaccttgt atttgaccag tctgtctttc cgctgaaaca ggctgtatat ttcgatacac 955381 ctgatggccg gatggtattt gcgattcctc gtgaaggcaa aacatacgtg ggaacaacag 955441 acactgttta caaagaggcg ctggagcatc cgcggatgac aacggaggat cgtgattatg 955501 tcatcaaatc aatcaattac atgttcccgg aactgaatat cactgcgaat gacatcgaat 955561 ccagctgggc ggggctgcgt ccgctgattc atgaagaagg caaagatcct tctgaaattt 955621 cacggaaaga cgagatttgg acatctgact caggcctgat caccattgcc ggcggaaaac 955681 tgactggata cagaaaaatg gcggagcaca tcgttgatct tgtccgtgat cgcttaaaag 955741 aagagggcga aaaggatttt ggaccatgta aaacgaaaaa catgccaatc tctggcgggc 955801 acgtcggcgg ttcgaaaaat cttatgtcct tcgttaccgc gaaaacaaaa gaaggaattg 955861 cagccggttt atcagaaaaa gacgcaaaac agcttgcgat cagatacggc tctaacgtag 955921 atcgcgtctt tgaccgggta gaagcgctga aagatgaggc cgcgaaacgc aacattccgg 955981 ttcatattct tgctgaggca gaatacagta tagaagaaga gatgactgca acccctgctg 956041 acttctttgt ccgcagaacg ggacgtttat tttttgatat caattgggta agaacatata 956101 aagatgccgt tattgatttt atgagcgagc gattccaatg ggatgagcag gcgaaaaaca 956161 aacatacaga aaacctcaac aagcttttac acgatgcggt cgtaccgctt gagcaataaa 956221 tcataacggg ctgtctgcag cccgttattt ctttttacgt gccgaaaggg ggagatctca 956281 ggttatcaag tgacagaggc acccgcttca tataaaataa tggcataagc tgatacatag 956341 gaggacgaat atgacttgga gaaagagcta tgaacgctgg aaacagacag aacatttaga 956401 tctggaatta aaagagcgcc ttattgaatt agagggagat gaacaggccc ttgaggactg 956461 tttctataaa gaccttgaat tcggtaccgg cggaatgcgc ggggaaatcg gcgccgggac 956521 aaatcggatg aatatttaca ctgtgcgcaa agcatcggcc gggtttgcgg catacatctc 956581 gaagcaaggt gaggaagcga aaaaacgggg cgttgtcatt gcttatgatt cccgccataa 956641 gtctccggag ttcgcgatgg aagcggcaaa aacacttgcg acacaaggca tccaaacata 956701 cgtgtttgat gagcttcgcc cgacgccaga gctgtcattc gctgttagac agctgaacgc 956761 ttatggtgga attgtggtaa cggcaagcca taacccgcct gaatataacg gctacaaagt 956821 atacggggat gatggcggcc agctgcctcc aaaggaagcg gacatcgtca ttgagcaggt 956881 aaacgcgatt gaaaatgagc tgacgatcac agtggacgaa gaaaataagt taaaagaaaa 956941 aggcttaatc aaaatcatcg gtgaagatat tgataaagtt tatacagaaa aactgacgtc 957001 catttctgta catcctgaat tatcggaaga agtagatgta aaggttgttt tcacaccgct 957061 gcatggaact gcaaataaac cggtcagacg cggtcttgaa gcactcggct acaaaaatgt 957121 aacggttgtc aaagaacagg aactgccgga ttcaaacttc tccactgtta catcgccgaa 957181 cccggaagag catgcggcat tcgaatatgc cattaagctt ggggaggagc agaatgcaga 957241 tattctcatc gcgacagatc ctgatgctga ccgcctcggc atcgcggtga aaaacgatca 957301 aggcaaatat acagtgctga caggaaacca aaccggagcg ttgctgcttc attacctgct 957361 ttctgaaaag aaaaaacaag gcatcctgcc tgataacggt gttgttctca aaacgatcgt 957421 cacaagcgaa atcggccgtg ctgtagcttc ttcattcggc cttgatacga ttgatacgct 957481 gacaggcttt aagtttatcg gtgaaaagat taaggaatac gaagcatcag gccagtatac 957541 cttccaattc ggttatgaag agagctacgg ttatttaatc ggggattttg cccgcgataa 957601 ggacgccatt caggctgcgc ttttggcagt tgaagtttgc gcgttctata aaaaacaggg 957661 aatgtcattg tatgaggcgc tcatcaatct ctttaacgaa tatggttttt atcgtgaagg 957721 gctgaaatcc ctgacgctga aaggcaaaca aggagcagag caaattgaag cgattcttgc 957781 ttccttcaga caaaatccgc cgcagaaaat ggcgggcaaa caggttgtca cagcagaaga 957841 ttacgctgta agcaaacgga cgcttctgac tgaaagcaaa gaagaagcca tcgacttgcc 957901 aaaatcaaat gtattgaaat acttcctgga agacgggtct tggttctgtc tccgtccttc 957961 tggaactgag ccgaaggtta aattttattt cgccgtaaaa gggtcatctt tggaagacag 958021 tgaaaagcga cttgccgtcc tttctgaaga tgtaatgaag acggtggatg aaattgttga 958081 gtcaacagca aaataattca agtatgagct gggtcattgt aaatgatccg gctttttctt 958141 tttctcatcc aaaagtctga aagaaaatca tcctacaagt gaagcaatga aatacaaaaa 958201 actggtataa tcttaaatac aagatcaatg ccggagtgag aaacgtgagc aaaacgagga 958261 tggaaaaatt aaaaacgctg aaaacgattg cggaaacctt aaatcaaggg cacgatatca 958321 aagcaacact ggatgaggtt ttaaaagagt tgctgagtct gacaaacctt caatccggat 958381 ggatttttct gatcgaagaa gatgggtctt atacgttagc ggccgacgct tatctgcccc 958441 cggctttaag ccgcaaggaa aaagtgctga tgtgcgaagg ggagtgttac tgcctgacga 958501 aattcaataa cggagggctt agaaaagctg caaatatcat gaactgcaaa cgcatcgaat 958561 cagcagaaaa cctgcattgt tttgacacag aagggattac gcatcatgca actgtgcctt 958621 tagaagacgg ggacagaaga ttcggattgt taaatgtagc ggcggccgga aaaaccatgt 958681 ttgatgagga agagctgcat ttactcgagt ctgtcgcctt tcagatcgga acggcaatcc 958741 agcgtatgag gctttctgaa tatcaacaaa aaaatgctct tttaatggag cgtaaccgcc 958801 tcgctcagga gcttcacgat tcagtcaatc aaatgctgtt ttccgtcagt ttaactgcca 958861 aagctgcgaa gacactaaca aaagatgaaa atttacagca gatgattgat ttcatccaaa 958921 acctatcaca ggacgcgctc gcagaaatga aagcgttaat ttggcagctt cgccccggag 958981 gattggaaaa agggctggct gaagccatta aaagctatgg tgcgctcatt ggattgaaga 959041 tcatttttac acaaaaaggc tgtcctgttc tgactgatga gcaggagcat atgctatggc 959101 gtgtcgtaca ggaagcttta aataactgca aaaagcatgc cggaacggat acggcgtatg 959161 ttagtctgac tgcttctttg tgccatgcgg agctggatat catcgatcat ggggcaggat 959221 ttcgctatga agcgcatgcc ggtctgcctt cacttggcat aaaaggtatg aaagagcgag 959281 cggaaaaagc cggagctaag ttttggattg agtcagcgct tggaactgga acaaagctgt 959341 ccatcaggct tccgctaaaa agccgaaaag gaggggcggt atgaaaattg tcattgctga 959401 tgatcatcat gttgtcagaa agggtctgcg ttttttcttt gccacccagg atgatattga 959461 agtcgtcgga gaagctgcaa ctggattaga agccctccgt gtcatcgaag agacaaagcc 959521 ggatcttgtg ctaatggatt tgtctatgcc cgagatggac ggcattcaag ccattaaaaa 959581 agcaatacag caatttccgg atacgaatat cattgtgctg acgagctact ctgatcagga 959641 gcacgtcatc cccgcgcttc aggcaggcgc gaaggcgtat caattaaagg atacggagcc 959701 cgaggaattg gtgaaaacac gacaagtgca tggtggcgaa tacaagcttt ctacagctat 959761 tatgccccat gtgctgacac atatgaaaaa tcagcacgac ccggaaaaag aaaaatacta 959821 tcaattaact agaagggaaa aagacgttct gactgaaata gcgaacggga aaagcaataa 959881 agaaatcgca gcagccttgt ttatttcaga aaaaacagta aaaacccatg tatcgaatct 959941 tttagcaaaa cttgaagtgg ccgatcgcac gcaagcagcg cttttcgcag tgaaatataa 960001 cctgaatgga gagatctcaa aatgaacatg ttagtcataa atggcacgcc aagaaaacat 960061 ggcagaacaa gaattgcagc atcctatatt gcagctctgt atcacacgga tttgattgat 960121 ctaagcgagt ttgtattgcc cgtttttaac ggtgaagcgg aacaatctga actgttgaaa 960181 gtacaggagc ttaagcaacg cgttacgaaa gcggatgcga ttgtattatt atcgcctgaa 960241 tatcacagcg gcatgagcgg cgctttaaaa aatgccttgg attttctaag cagcgaacaa 960301 ttcaaatata agcccgttgc attattggca gtagcgggag gcggaaaagg cggcatcaat 960361 gcgctgaaca atatgagaac tgtgatgcgg ggtgtctacg ccaatgtcat tccgaagcag 960421 ctggtgcttg atccggtgca tattgatgtt gaaaatgcta cagtggctga aaacattaag 960481 gaaagcataa aagagcttgt cgaagaactc agcatgttcg caaaagcagg aaatcccggc 960541 gtctaaacgc cgggatttgt ttatgtgaga agggctattt gatcttcata agtcagctct 960601 gtggcatgat caatatatcg gagaagggaa tacagcatct tttctaaaac ggcgtaatcc 960661 tgttcaaaat gatacgcatg cagaaaatgc tcaattcgtt ttgataacaa atcgtcctct 960721 gtacgcacca ttaaaattaa taaattatcc cattgagaac gatgggtgta ataaagcgct 960781 ttatcgtaat cggcataatc catgaatcgc ttctcctttc ttgggtgaga agttcatgat 960841 tagtttatgc cgcatcctct gttattgacg gggcaaaact tgccgtctgc gtcagtaaag 960901 gggtagcaat atgagggaga cataaaatca aaatgcctga atgaagatat cgcttttggt 960961 aaacctatga gggaatatat tctgggtaca ggagactgaa aaaatgaaat ccctgccgta 961021 taccatcgca cttctttttt gcggattgat tatcgtgtca atggctgcaa aaggtcattc 961081 aacggacaca gacgagtccg ttcaaaagtg ggaacagctt gcctggagca aaattcagga 961141 tgaatataag ggcgcttcat tttctgatta tgcttatatg gggcgtacag aggtgaatga 961201 tcagcagact aaagatgtct ttcgggtgac agtcagacag aaagatgaca ctttttctgt 961261 tcgggccgaa gtctattttc atccggtgac aaatcatatg atcagcatca acgtctttag 961321 gctctaataa aaaactgtac agccgttaag gccgcacagt ttctgttttt agaaatatcg 961381 ttttgcaccg agatagcgct gtttccagta agagttgttc atattggaaa tgacaactcc 961441 ggaatcgttg gcatttatga attccccgtt gcctaggtaa attccgacgt gggaagggcc 961501 ggctttatat gttgaaaaga aaacgaaatc tccgacagca ggctggctaa ctgatttcat 961561 tgtgttccaa tatcccgctg ccgttaatct agatacggat gtgactttgt tcagtacata 961621 gtaaatgaat ccgctgcagt caaacccgga cggtgtcgtg cctccccagc gatacggaac 961681 cccaagctgc gctttagcgg ccgaaatcat tgtgttaatc ttcgcactcg ttgagctggt 961741 ggtgtttgaa gaaccggatg aagacgatga tgaagctttt ccggaaatga ccagcttttg 961801 gccaacctgc aagacatccg tttttaaatt gtttttctca cgaatctgct gagctgttac 961861 attaaatttt tgagcaatca cccataagga atcaccgctt ttcaccgtgt atgtagtcgt 961921 cgtgccggag cttgcatttg acgaagaaga cgacgatgat gaagagcctg aagatgcttt 961981 acctgtcagc ttcaatactt gtccaacgta aagcacatct gatttcagat tgttgatatt 962041 tcggatttgc tgtacagtca ggttatagtt gtttgcgatt ttccaaagtg aatcaccgct 962101 tttaacggta tatttagttg ttgctgaagt ttggttcgat ttggatgaat tgtctttaga 962161 agacgtatca gagccgcttg attttgtttt caacacctga ttcacgtaaa tggtgtctga 962221 ttttaagttg ttcaagacct tcaattcagc gatggacata ttgactttgt ttgcaatttt 962281 ccaaagtgaa tctccaagct gcaccttata tgttcccgta gaagatgaag aacttgaact 962341 cttattagaa ctgctttttg aactggagct tgaactctta ttagagttgc tttttttact 962401 ggaactagag cttgaagaaa cagtaccgga cacctttaat ttctgcccag cacgaattaa 962461 atcgctgctt agtccgttta attttttcag ttcctgcacc gtcattttaa actcatttgc 962521 gatcagccaa agtgaatctc cgcttttcac tgtgtaaaca gaacttccgc tcttcttggt 962581 tgttgagctt gaagtagatg aagaagtgct ggatttgctg cctggaatag taagcgtctg 962641 gccgatcgac agaacagtag tcgaaagatg attggcggat gtgagggccg ccacacttgt 962701 gttataggtt tgggccagtt tccataaaga atctccgctt ttgaccttaa tcgttgctgc 962761 ttcagctggt gtcactacta aagttgtgcc gacaatcgca gatgctgtca gccctgctgc 962821 taatttcttt ttcatcttag ctctcctttt tcccccaatg attttgcatt tgctgtttct 962881 tttttatatc ggcacatttg tctcatcgtt ttgccttttt ataaaaatag ccaaattatc 962941 ttaacaataa gggggaaaaa gggcataaaa aaagaaggaa tcttaatcta ttccttcatt 963001 tttaaaagct tcatgatatc ttctttgttt ttgacgaggt cgcgcagtgt gtatttgtct 963061 aaaactgcga ggtaggctaa aagcgcttca ttcagcacat gttttaagcc gcaaaccggg 963121 gaaataacac agagattctt gttcgcatca aaacattcaa caatattaaa atcgtcctcc 963181 gtttttctga caacctcacc gatgttgatg tcttcagggt ccatgcctaa tcgtatgccg 963241 ccgccccgtc cgcgtatcgt ttctacgtag ccgagctggc cgagcctgta tatgactttc 963301 atgagatgat tttttgaaat agaatacgtt tcggcaatct gttttatatt tgaaagttct 963361 ccgggacgct ctgcagccag aaaaatcaac actcttaatg aataatctgt ataattggtt 963421 aacttcataa taagacctca gaataagaca ttttctatat cttatcataa tcgattgaaa 963481 aatgaaaaaa aaggaattaa aaaacatgca cccagctggg tgcatgtttt ttgcttacat 963541 gtcattcggc ggattttggt ttttacggtt tttttcgatt tctgtgtttt gcattttgcg 963601 ttcaaatgta gacagataac gtgatgcaaa atccttaccg ccaaggccga aggataaacc 963661 aaaagcaagt gcgaagccgc taagaacgat gatgaacgcg gaattgacga ttgtcgcagc 963721 gacacccagc tgatccaggg ccataaagaa agcaagtgcg ataatcgtat atttagcaat 963781 aggcgctaaa gacttgaatt cctgaccttt tatcatgctt gcgagcactt ttctcaccaa 963841 ttctcctgcg taaaggccga gtccgagaat gaatactgcg acaaggacat tcggcagata 963901 cgcgatgatg ccggtggcaa tttctacgag gaagtgcagc cgaacaattt gaagcgcctc 963961 agctgtaaag agcagaatga caatgatttg cgcaatcata ccgacaactt gagacaagga 964021 cagctttgca ggcgttccgg cttccatgcc cattttccct aagacagaat caaagcctgc 964081 gcgatggagc agtccggaca ccatggattt cacccatttt cctgcccaga tacccgctaa 964141 tacaagcacg atggcaatca tgatgttcgg aagcatgttt aaaatcgtat tcagcataga 964201 gacagctggt tttgaaatgc cggcgacatc cagctgatca agcgctgaaa tgaccaccgg 964261 aatcataatg agcacataag cgattgttcc gatgactgct gaaaggcttg tgtcttttaa 964321 gtaaattgat aaacccatac gtgccgcgaa tctttcggtg ccgatgcttg caaggaaatt 964381 cgtaatgata tcacggacaa ggcgggcaac aagccatccg attaatacga taagcgccgc 964441 tgcaaataat ttcggcagaa aagcgagcac gctttccatc atatttgtaa aaggacctga 964501 aatgccgctg attttcaaag aagataagac ccctggcaga aaaacaagca gcacgagata 964561 aaagacaatt tgtgaagcgg tattgacagc ctggtgaata tcttttcctt cagacaccaa 964621 attccacttg cgcagtttgt cactcgtgtt cagcttcatc ccgatttttt tgacaaggaa 964681 gctcaaaaca gaagctgcag cccatcctaa cagcagaatg agtccggctt tcagcacgct 964741 tgggatcgca gctgcaatcg ccgaaagcat actgacaaac ggcgatgcca ctgttgtcag 964801 gtgcaaaatg ttaaagaata aaataaagac gatgatcagt gcgataaaat aaacgacctt 964861 gcttatgact ttttccgagg aatagcgtga aggctttttc ccagcaaaga gcttgtcgtc 964921 gatttttgtt ttgctgagtc ctttgtatac cgctttttca atgattttag caatagccca 964981 gccgattaat aagacgagta aagcaatgat tacgtttggc agcttactga gataagaaga 965041 aaacacgtct gctacattca attggtatcg ctcctttttc gtagtatggt gtgtgtttac 965101 ccacttatcc aataagcaaa cagatgaatg tgccggggga attttttctt gcccgagtga 965161 gactatcatc ttttgtctgg cgggctcata cattatagat aagtccaagt aggggggatt 965221 cggttgaacg cggaggagaa gaagggatta cagcgggcaa ttgaggaaat taccgaaatt 965281 gcaaaaggat tcggccttga tttctacccg atgagatatg aaatctgccc ggctgaaatt 965341 atttatacat ttggcgcgta cgggatgccg acaagattca gccactggag cttcggcaag 965401 cagtttcaca agatgaagct gcactatgat ctagggttaa gtaagatcta tgagctggtc 965461 attaactcag atccatgcta cgcttttttg ctggacagca actcactgat ccaaaataaa 965521 ttgattgtcg cacacgttct tgctcattgc gatttcttca aaaacaactg ccgtttccaa 965581 aacacgaagc gcgatatggt ggaaagcatg gcggcaacag ctgaacggat aaaacactat 965641 gaacaggttc acgggataaa agaagtcgaa tcttttttag atgcaatcct ttcgattcag 965701 gagcatatcg atccgtcgtt ggtccgacca aagctccaat ggagtgtgga tgatgaggaa 965761 gaggagattg aagaggcagc cacgccttac gatgatctat ggtctttaga tgaaaagaaa 965821 ccgaaaaaac aagtgaaaaa atcgaaaaaa ccgttcccgc cgcggcctga aaaagatatc 965881 ctgcttttta tcgaggagca ttcccgggag ctggagccat ggcagcgtga tatattaacg 965941 atgatgagag aggaaatgct ttatttctgg cctcagctgg aaaccaagat tatgaatgag 966001 ggctgggctt cctattggca ccagagaatt atacgtgagc ttgatttaac ctctgatgaa 966061 gcgatcgagt tcgccaagct gaatgcaggt gtcgttcagc cgtccaaaac aggcattaat 966121 ccttattatt tagggctgaa aatatttgaa gacattgaaa agaggtacaa caacccgacg 966181 gaggaaatga agaaaatggg cgtgcagcct gactccggcc gggagaaaat gtttgaggtc 966241 agggagattg aatccgatat ctctttcatc cgcaattatt taaccaaaga attagtcatg 966301 cgcgaggatc tttatttgtt tcaaaaacag ggccgagatt ataaaatcat cgataaacag 966361 tggaagtcgg tgcgcgacca gctcgtaagc atgcgggtaa atggcggttt tccatatttg 966421 acagtaaacg acggcgatta tatgaaaaat aacgaactct atattaagca ttggtatgag 966481 ggcatagagt tggatttgaa atatttggag aaagtgcttc cttatttatt ccagctttgg 966541 ggaagaagcg tgcacattga gtctgtgctt gaggataagg aagtcatgtt ttcgtacgac 966601 ggaaaaggtg ttcaccgcag atatttataa aaaagaggat gcagcgttct gcatcctttt 966661 tattttccag tttttaaaat cttaaatatg atgtttgcct ggtccgtatt gttaatcaat 966721 ccgcggaatt tttcttttcc ggggccgtac gcgtataccg gtacttcttc gccggtatga 966781 tcggtactcg tccatccgct gttggagcgg gtattaaaaa tcttgatgat ggctttggag 966841 gcccctttgc ttttgtcagc ctgtgcagct gcttcaacgc ttttgatttc ttcagatgtg 966901 actttcagat tggcatagcg ggcgagcaca tctttaaccg gcttgccttc actgattttt 966961 ttggccatga attcaggtgt tttcttagcg gagagaatcg gttctgcgtg ccaattcttt 967021 tccccgtttg cgccaatggt aaagccgccg gttgtatggt cagcagttgc aatcacaagt 967081 gtatgtttgt cttttttcgc aaattcaatc gcggctttat aggcctgttc aaaatcttta 967141 acctcgctca tggctcctac tgtatcattg tcatgggccg cccagtcaat ctggctccct 967201 tcgaccatca agaaaaatcc ttttttattt tggttcaggc gatcaattgc tgaaaccgtc 967261 atgtctttga gagacggtgt tttactgtca cggtcgagcg ctttagcaag ccctccatct 967321 gcgaaaagcc cgagcacctg ctgatcttta ttttttttca atgcttgttt agttgtcaca 967381 tagctgtagc cggcttgttt gaattccttt gtcaagtttc tgtccttgcg gttaaaataa 967441 gattttccgc cgccgagcag cacgtctatt ttatgtttgc cttttatctt gtcatccata 967501 tagctgttgg cgatttggtc catgtttttc cgtgattcat tgtgggcgcc atatgcggct 967561 ggagtggcgt ggttaatttc agacgtggcg acaagccctg ttgacttgcc ttgctgtttg 967621 gcctcttcaa gtacagattt cacttttttt ccgtttttat cgacgccaat tgcattgtta 967681 tatgtcttaa cgcctgtcgc taatgctgtt ccggctgctg ctgaatctgt aatattatag 967741 tcagggtcat ccggatgcgt catcatcatg cctgtcaggt tccggtcaaa ttctgttaac 967801 ttcgggttat tcggtgtgtc accgttattt ttcatggaac ggtaggctct tatgtaaggc 967861 gtccccatgc cgtcgcctat catcacaatg acatttctga tctcagcttt gtcttgtttt 967921 ttggcgctgg ccttttctgt ttgctgaagc tcagctccgg caaagattcc agctgtaagg 967981 acagaaacag cggcgattgg cagaagtttt gatttcatat tttgaaacaa actcattttt 968041 ttcatgcctc ctttaatgta ttccgtttat catgttaggg aaactttgtt aaatgcggct 968101 gttgatcatg taaacaataa gtaaagcctt gtaaggaaat gaaaaaacgc ttttcgttat 968161 cttgccttat ttgatgtaaa gcattcattt ttcagaaaaa tctttacctc tctgtctttg 968221 catgatatgt ttgtttaaat aaaaaaactg cggataacca cagctctcct cgaatatact 968281 ttatcactca tttttccgat atatgagccg accccgaaag tttttcattt atttccttta 968341 tgttgaaaaa catcccataa aacatgacaa aagcactcgt tttttgtcac ctttgcaatg 968401 aaaatgaaat atttaatacc cttaaaaact tttttttaga acgaataatt aagaaatttg 968461 tcacatgaag tcaagactat ttctgatggg aatctatcct tataatagaa atcaataaga 968521 ttaatttaaa aaaagagata catatatata gagttaacat ttggggagga aaatatgaaa 968581 aagcaaatca ttacagctac gacagcagtt gttttaggat cgacgttatt tgcaggagcg 968641 gcatctgcac aaagcattaa ggtgaaaaaa ggcgacacgt tatgggatct ttcaagaaaa 968701 tacgacacaa cgatcagtaa aattaaatca gagaaccacc ttcgttcaga cattatttat 968761 gtgggacaaa ctttatcgat taacggcaaa tctacaagtt caaaaagcag cagttcttct 968821 tcctcttctt ctacatacaa agtaaagagc ggggacagcc tttggaaaat ttcaaaaaaa 968881 tacggcatga caatcaatga actgaagaag ctgaatggct taaaatcaga tttgcttcgt 968941 gttggacaag tcctgaaact gaaaggttca actagttcaa gcagctccag ctcatcaaaa 969001 gtgtcatcgt cttcaacttc tacttataaa gtgaagagcg gagacagcct ttctaaaatt 969061 gcgagcaaat acggcactac ggttagcaaa ttaaaaagct taaacggctt aaaatcagat 969121 gtaatctatg tcaaccaagt attgaaggtg aaaggaacaa gcacaagcag ctcaaaacct 969181 gcttcatctt catcgtcttc aagcagcaaa acgtcatcta catcacttaa tgtgagcaag 969241 ctggtttctg atgcaaaagc gttagtcgga acgccatata aatggggcgg aacgacaact 969301 tcaggctttg actgcagcgg attcatttgg tacgtactga ataaacaaac aagtgtgggc 969361 agaacaagca ctgcaggata ctggagttct atgaagagca ttgccagccc gtctgttggt 969421 gatttcgtct tcttcacaac atataaatcc ggcccttctc acatggggat ttacattgga 969481 aacaacagtt tcattcatgc aggatctgac ggcgtacaaa tcagcagcct gaacaacagc 969541 tactggaagc ctcgttacct cggtgcgaaa agattctaat ttttagagaa aacccgttca 969601 ttggaacggg tttttttcat tagacggagc acaggcgttt tggttgctcc taaaaatgaa 969661 aatgtgataa aaaatccaag aacttttttt ctttcttatt ttcataaagg gcaatcgcgt 969721 aagcgccggc atagggcagc tgtacagact gataaggaat tctgatcatc tgtttctctg 969781 ctaactcacg ctttactgta gataaaggca gaaatgaaac tccgagtcct tccttgataa 969841 accgtttcgt tatatgtgtt tgagtgacct tcattgttct cacaaatgga aatgtcattc 969901 tgacttgacg gagcaagtcg tcccagtaat caggatgatt gtgggtcaaa agcaggtatt 969961 gttcgagcac ctctttggca tcaatttcgt tgtcttctat gaaacgctta tcgggcgggg 970021 caacaaggac gacagggtct ttgtataagc agtggcagct taaagaagaa gactgtacct 970081 ttaaacagct tagtccgata tctgcttccc cggctttaat cagtgacgcg atttccgctg 970141 attcgaaaat cgtaaccgcc atttctgttt ccgtattcat tgctgtgtac cgcttcatga 970201 cagaaggaag cactgtatct gcaataagcg gagaaaccgc gagctgtaag gtttgagagt 970261 agccttgtct cactctgtga agctctgcca tgctgttttc ataatcatca agaagcctga 970321 gcgcatacgg caaatacgcc ctgccttcat cagtcagctg gatttgcctg cctttacgct 970381 cgaacagctt gcagctgatt tctttttcta attgcttgat atgtacggtc acagtaggct 970441 gagataagaa aagcgtttcc gccgtttttc ggaagttctc atattttgca gcggtcacaa 970501 aggtgtgaag ccatttgaaa tccatttcta ttctccctct gattaatatt tttaattaat 970561 tccctttaaa atattgatta ttttttaaat attatattta ctataataac agaaaaggat 970621 agggggaata caaatggtac attacggatt aaagggaatt acatgtgtag aaacatccat 970681 cagccatatt gatggtgaaa aagggcgtct gatttacaga ggacatcatg caaaagacat 970741 cgcactgaat cacagctttg aagaagcggc ttatttgatt ttatttggaa aactgccttc 970801 aactgaagaa ttgcaggtat ttaaagataa gctggctgcg gaacggaatc ttccggaaca 970861 tattgagcgc ttgattcaat cactgccaaa caacatggac gatatgtcgg tgctgagaac 970921 ggttgtttca gcattggggg aaaatacgta cacattccat ccgaaaacag aggaagcaat 970981 ccggctgatt gcaatcacgc cttctatcat tgcatacaga aaaagatgga cgcgcggtga 971041 acaagcaatt gcaccttctt cccagtacgg acatgtcgaa aactactatt atatgctcac 971101 aggtgaacag ccttcagagg caaaaaagaa agcgcttgaa acctatatga ttctggccac 971161 ggagcacggc atgaacgcat cgactttttc ggcacgagtc acgttatcta cagagagtga 971221 tttagtgtca gccgtcacgg ctgctctcgg tacgatgaaa ggtccgctgc acggaggtgc 971281 tccttctgcg gtgacaaaaa tgcttgaaga cattggagaa aaggaacatg ctgaagcata 971341 tctgaaagaa aaactcgaaa aaggagagcg cttgatggga ttcggccaca gggtgtacaa 971401 aacaaaagac ccgcgggcag aagctttgag acagaaagca gaagaggtgg ccggcaatga 971461 ccgtgatctt gatcttgcgc tgcatgtaga agcagaagcg attcgtttgc tagaaatcta 971521 caaaccggga cgaaagctgt acacaaatgt tgaattttac gcagctgcag tgatgagggc 971581 catcgatttt gacgatgaat tgtttactcc gaccttttca gcaagccgaa tggtagggtg 971641 gtgcgcccat gtactggaac aggcagaaaa caacatgatt ttccgcccgt cagcgcaata 971701 taccggtgcc attcccgagg aagttctttc ataacatatt ttggcgttta ttcatttctg 971761 tcgtgtggta acgttcagta tcaaccacat gtctaggagt gatgaatgtg aacccaatgg 971821 acagacaaac agaaggacaa gaaccgcagc atcaggacag acagccgggc attgagtcaa 971881 aaatgaatcc gctgccgctg tcagaggacg aggattatcg aggaagcgga aaactgaaag 971941 gaaaagttgc gatcattact ggaggcgaca gcggaatagg gagagcagca gctattgcct 972001 ttgctaaaga gggggctgat atctccattc tatacttaga cgagcattcg gacgcagagg 972061 aaacacgcaa acggatcgaa aaggagaatg tccgctgcct gcttatcccg ggagatgttg 972121 gggacgagaa ccattgtgaa caagctgtgc agcaaacagt ggaccatttt ggtaaactcg 972181 atatcttagt gaacaacgcc gctgaacagc atccccagga cagcattctc aatatttcaa 972241 cagaacagct ggaaaaaacc tttcgcacaa atattttttc catgtttcat atgacgaaga 972301 aagctttgcc tcacctgcaa gaggggtgtg ccattattaa tacgacatcg attaccgctt 972361 atgaagggga tacggcgtta attgattatt ccagcacaaa gggtgcgatt gtttccttta 972421 cgcgttccat ggcgaagtcg cttgcagata aaggcatcag agtgaatgcg gtggcgcccg 972481 gtccgatttg gacaccgctt attccggcga cattccctga ggaaaaagtg aaacagcacg 972541 gcttggatac cccaatggga agaccgggac agccggttga gcatgcaggc gcctatgttc 972601 tgctggcgtc tgacgaatct tcctatatga cagggcagac cattcatgtg aatggcggcc 972661 gttttatttc aacgtaatca acgaaaaacc agctcaagag ctggtttttt gtgtggtgaa 972721 aaatttcaaa ataaaaaatt tgtcgatttt tctaacaatt ttgttttcat ttttgcaatt 972781 ttatatataa tattgagtag gagaaaggaa tgattcgcga ccagtacaaa tatagtagaa 972841 aaaaaagaat aatgaccatt gttactcatg aattcagaaa attcaaataa aatatataaa 972901 aatagatgat cgggagttga aggggaatga aagggagcgt ttttaggaag aaaagcattc 972961 aggatttaat cgctgcgacg agcggggaaa agtctttaaa aagagaatta ggggcatttg 973021 atttaacgtt gcttggaatc ggcgccatta ttggcacagg gatttttgtt ctgacgggaa 973081 caggcgcagt cacggccggt cccgggctga cgatttcatt tgttgtggcg gcgttggctt 973141 gtttattcgc cgccctgtct tacgcggaat ttgcgtcaag tgtgcctgtt tcaggttcgg 973201 tgtatacatt cacttatgcg acattgggag agcttatggc ctttattatc gggtgggatt 973261 taattttaga atacatgctg gcggtaagtg cagtgtcggt cggctggtct ggttatttcc 973321 aatcgttttt atcagggctt ggcattcatc ttccggttgc tttaacagcg gcaccgggcg 973381 cagtgaaagg cacctttacc ctgtttaatc ttcctgcatt cgtcattgta atggcgatca 973441 catatttgct ttatttaggc atcaaagaat caaaaagagt caacaatatc atggttatct 973501 tgaagatact ggttgttctg ctgtttatcg cggtggcagc cgtttacgtg aagccgcaca 973561 actggcagcc gtttatgcca atgggctttg gcggcgtgtt cagtgcagcg gcgctcgtat 973621 tctttgcttt tatcggattt gacgctgtat cctctgctgc ggaagaaacg aaaaatcccg 973681 cgaaggatct gcctaaaggc attattttct ctttactggt ctgcacgatt ttatatgtca 973741 ccgtatcagc catcatgact ggggttatcc cgtttgctca atttgcgggt gtggatcatc 973801 cggtttctct tgttcttcaa agcgcagggc aaaattgggt ggcaggcatc attgatattg 973861 gcgccgtgtt gggaatgaca acagttatgc tcgtgatgct ttacgggcag acccgcgtca 973921 tgtttgccat gtcgcgtgac ggacttgtgc cgggttcact ttctaaagtg catccaaagc 973981 acaaaacacc ttatgtagcc acttggtttt tcggaacgat gtcggcgctt ctcggctcac 974041 ttgttccgct ggatgaactt gcaaagctgg tgaacatcgg gacgttgtcg gcatttgtcc 974101 tgatttctgt ggcagttatc gttttgagaa agaaacagcc tgatcttccg agagctttta 974161 aatgcccggg agttcccgtg atcccaggcc tggcgattct gttctgcctg ttcttgattt 974221 taaatctggg atgggtgacg attgtccgct tcctagtgtg gctgttaatc ggcttggtaa 974281 tctatttcct gtattcaaga aagcattcaa aattaaatca ataacctttt gataaagaga 974341 gcggccatac aggccgcctc ttttctgttc ttggcaaatg aatctataga aatgaagaca 974401 aaaataagag ataatatagg ctggaaagga agtgacgttt attgtctgag caaaaaccag 974461 tccaatgggc ttcgaaaatt ggtttcgtca tggcagcggc cggctcggct atcggcttgg 974521 gcgcgatttg gaagttccct tacgtagcgg ggaccaatgg gggaggagcc ttttttctta 974581 tcttcgtgtt atttaccatc ctcttaggct atccgctttt ggtgggggaa tttatttttg 974641 gaagacggaa ccagacgaat gccattgatg catataaaaa agaagcgccg cgatcagctt 974701 ggtttcttac ggggtggatc ggcgtagcgg cgtgtttctt agtgctgtcg ttttacagtg 974761 taatcggggg atggattttg ctgtatatcg tgaaaacagc gtcaggatca ctgtccgggc 974821 tttctcaagc acagtatggc gctctttttg cttctattat ccaaaatccg gtgcagacgc 974881 tcgcggctca gcttgtcttt atggcactga ctgtactcgt tgtcgcaaga ggggttcaaa 974941 aagggattga acgggtaagc gcggtgatga tgccgatttt gtttttattg tttattctgc 975001 tcgttcttcg gtctcttacg cttaatggtg caatggaagg cgtaaagttt ctgcttgtgc 975061 ctcatttcgg cgatctgact ccggaatcca tattattcgc gctgggacag gccttcttta 975121 cgttaacact gggggtttcg gtgatggtga cctacagctc ctatttgccg aaaacacaaa 975181 atatccctcg ttcggcagcc tccattgtct tgatgaatat cattgtgaca ctcttggcag 975241 gtttggctat ttttccggcg gttttctcat tcggttttca gccaaatgaa ggaccgacat 975301 tgctgtttac agtgcttccg gccgtttttg aacagcttcc gttcggcaca ttgtttttta 975361 tcggctttct cgttgcattt ttatttgcag ccttaacctc agcattttcg atggttgaaa 975421 ttatcgttgc cacaatcgga aaaggggacg aaaagaagag aaaaaaactg tcatggacga 975481 gcgggctttt gatctttttg gtcggaatcc catgctgctt gtcttatggc gttttgagtg 975541 atgtgcacct atttggcaaa acgttttttg atattgccga ttttaccgtc agcaatgttt 975601 tgatgccttc aggcgctctg ttaatttctc tatttatccc gctgaaaatt tcgaaaagcg 975661 aactcttggc tgaaatgcga aatggatcaa atgcaggtaa agcattcttt tacacatggt 975721 tttatttgct tcgttttatc gtgccgcttg ccattattat cgtgttctta aatttaatcg 975781 gaattttatc attttaaaaa acaggctccg tttccggggc ctgtttttta tttaataaga 975841 tgatatcaac ggtgcccatg ccgttttcag tttttggatg ccgagcctga tgtcctcttc 975901 tgacaaaccg ccataaccga ttaagacaga agtaaaaggc gtctgttcta tatatgaggg 975961 agacacggga tagagggtta caccgtggtc agcggctgct tgtattgctt cttcctcact 976021 tgctggaaac aaaaggcgca gcagaatgtg aagccccgag ttcttaccga gaatctcaac 976081 ggtgtttccc agttcagagc gaatggcttc taacaggaca gcgtgttttt ttcggtataa 976141 gcttctcatt ctatttatgt gtttttgcca ctctccggtt tcgatgaagt ctgccagtgc 976201 caattgcgag tgggcagaaa cggtctgctt cattaactga acattgtttt ggatcggttc 976261 catgagttca gggggcacaa tcatgaagct gagccgcaag gaaggcagaa gtgactttga 976321 aaaagtgccc agatatatga ctctgccatt cggatcaaga ccctgtaaag acggaatggg 976381 atggccgctg tagcgaaatt ctccatcgta atcatcttct ataatgaatg aatttgtttc 976441 tgccgcccat gccagcagct cctgtctgcg ggtaatcgtc ataatggtcc caatcggaaa 976501 ctgatgcgaa ggagtcgtat acatgagata aggattctga cggtagagct catccggcag 976561 gacgccttct gcatcagaac aaatcggagt gacatccatg tgatttgctt caaacatcct 976621 tcttgaacgg tgaaagcccg gttcttcaaa gccgattttt gtacctggct ttagcgaaag 976681 gcaaagattt tgcagaagca cggtggttcc tgcgccgatg ataatctggc cgggttcaca 976741 atttactccc cgagacagcc tgacgaatcg ggcaatcatg tgcctgagtt cgtattctcc 976801 ttgagggtcg ccagaggtgt gaaacgatcc ggaatagcga tcaagacttt ttactatgct 976861 ttttctccat gcgttaaagg gaaagagggt cggatcaacg ctgccctgat ggaagtcaat 976921 agcaggtgcg tttttttgat gtaatcccgg ctgtacagac tgctgaaaat ggtcaggagc 976981 tgtcgggaat cctggttcta cttccgccgc gaaccagccg attttcggct tgcttttgac 977041 atagccctca gcagttaatt gctcataagc tcgttctata gttgccgtgc tgacatcgag 977101 caagctggag agcctgcgtt ttgacggaag tcttgttccc tttgtgattc gcgcatgtga 977161 aatttcttgt ttaaaaaagg tataaagctg ttcatacagc ggtgttttgc tctttttatc 977221 aagaaacggc gtaatatcca tctcatgtct cctttgtagc tggcatggtc attttttctg 977281 atattggcta tttggcaaat gccatttatt agctatgatc attgtaacga aaggaaaggg 977341 gattgagaag atgatccata tgaaacaatt aacctcgaaa gaagaatggg ctgagtcgta 977401 tccgattatg agtgaattga gaacagaact ggatatagag acgtatttac aaaggcttga 977461 agcctgtgtg cagaaagaat cgtatatgct gtttgcctta tatgaaaata cagcaatcag 977521 agcgctgtgc ggggctctgc cgagagtttc cattcataaa ggagagcact tgtggattgc 977581 ggatcttgtt acaacggcac cttgccgatc aaagggatac ggcaaaatgc ttttggatta 977641 tgcctcagac tgggcgagaa aagccggact cggttttgtc agtctttcat ctggccttca 977701 gcgtaaagac gcacatcgat tttatacaga taaaatgggt tttactatag aaagttattt 977761 gttccgaaaa ccggtataac gaaaaaagac gcctgaaaag gcgtcttttt taaaagccaa 977821 actgtaaatt cgtatctaca gatacaatgg tatacacaca aataatcaca aagagattaa 977881 ggatgacgcc gagcaggcct ggacctgtgc gccctctctt gatgaagagt tcaacaacgc 977941 cgaacggaac ggcagccatg gcgaacggaa gcatttgata ggaataaaac gtgacgttgc 978001 tgataatggc caaattcagc aacagcaggg acagaaccgc tgtcccgaca gagatccagc 978061 cgaatacatt gtgttcttta aaaattctta ccagttccat aattccacct cgccgacatt 978121 cgctgatttt acagatttat ttttcagcat gcgctggatt tccttggttg gccctgtaac 978181 gaccgaaccg tatacattga caccgttttt ctctacataa tctaatcggt tatctacatt 978241 caggtctttc cgttttgaaa tgacctgagc ccatttttcg tgtttggaca tgaatttcag 978301 ggcgttgata aactgatcgc cattcgactt gccttttgta ttaagggcgg ccaagaactt 978361 tgaatccttt ccaggatagc caagaggttc tgtggaagct gtcttatttg tgtttttctc 978421 tgtttcgatt gcgttccaca aaaagctcac atcatagcct ttgaatttgt tatacacgtc 978481 ttttgtcgga tatgcacggt catatgaaag gtagacctct gataccgttc cttcaggcaa 978541 tgtgcttaac gttttttctg cttttgcggt cgtttgttca gacttgtttg aaggatgtgt 978601 aaagtaatgg ccggttttat tcacttctaa gtcatagtag tttactgccg gcgcttttac 978661 tttgttataa aacatttcaa cccgttcatt ccctacggca gccgtcttcg tgccaatctg 978721 cttttgcagc gggaattccg tattcattcc aaatagcttc acttggcttt tcagtccgga 978781 agtatcaaca agaacattcg gcatggtcag ggctacagtg actgcggcag tttccataaa 978841 ctcattgccg gtgctgtgtt ttccacccat tccgtaatag aggtagcttc ccagcgtaca 978901 aagcggcaaa atcatcaatg tcgaaatgac ggcaagcaca gaaattcgca aataagactt 978961 gcgtttgccg taggctaaaa tcgctttttg tttttcagga ctgatgctga gatcccaatc 979021 gttatcgtcc tctagttcgc tgtcaatcag ttcctgatat acttcaagct tctcgagttc 979081 ttcctcaaat gcagtcattt cctggtcgct catttcccca tttttatatt gatcaaaacg 979141 ctttttaaat tcttcattca tcattaacac ctctattata aagtgctttc agccgctgtc 979201 tggcacgaaa taaaacactt ttaaaattcg cctctgaaat attcataata tgggatgctt 979261 ctttgtagtt taactctttt aaataatata gcgttaaggc ctcccgataa ttatcgggga 979321 gctcggacat ataaccagtc agcacttcct ttatctctac ctgatgggca ggactttgaa 979381 cagcattttg aaagaggctt ccgattaagt catcagaaat ggttacttct ttcttatgct 979441 ttctgacgta atcaatgaag gcgtttcgcg ccacttgaaa aagccagggc tttactttgc 979501 tgtgatcata ggagtgaatg tgtatgtatg cccgcataaa ggtttcctgc agtaagtctt 979561 cagcaagatg cttgtctttt gtcatggaga gcaggaacct gtaaacatca ttcatgtaca 979621 tttggtaaat ttcatcgatc gtcactgcct tttctcccct ctatgttata cacgcataag 979681 aaaggtttaa agttgcacat tacatgcaaa cggctttttt atacctaatc aaacaccatt 979741 actatatagt acccaaaaat ggccgcaaaa gatagtgcgg agaaaggttt aacatttttt 979801 ccagagggga aaagatagtg aaaaagtgaa ggagtggcac aatggaatat accagtatag 979861 cagatacagg aatagaagcc tccagaatcg gcctcggcac atgggccatt ggcggaacga 979921 tgtggggagg cactgacgaa aaaacatcga ttgaaacaat ccgcgccgct cttgatcagg 979981 ggattacact gattgacacc gcaccggctt acggcttcgg gcagtccgag gaaattgtcg 980041 gaaaggcaat caaagagtac ggcaaaagag accaggtgat tctcgcaacg aaaacggctc 980101 tggactggaa gaacaaccag ctgttccgcc atgcgaacag agcgagaatt gtagaggaag 980161 ttgagaattc tttgaagcgg cttcaaacag actatattga tctttatcag gtgcattggc 980221 ccgatccgct tgtgccaatt gaagaaacgg ctgaagtcat gaaggaatta tatgatgcgg 980281 gaaaaatccg ggcgattggc gtcagcaatt tttcaattga gcaaatggat acatttcgcg 980341 ccgtcgcacc tctccatacg attcagcctc catataatct gtttgaaaga gagatggaag 980401 agagtgtcct tccttatgcg aaagataaca agataacaac attattatac ggcagtttat 980461 gcagagggct gttaacaggc aaaatgactg aagaatatac atttgagggc gatgatctgc 980521 gtaatcacga tccaaaattc cagaagcccc gctttaaaga gtatctttct gctgtgaatc 980581 aattggataa gctggcgaag acacgttatg gaaaatcagt gattcacttg gctgtcagat 980641 ggatcttaga tcagccggga gcggatatcg ctctttgggg agcaagaaag cctgggcagc 980701 ttgaggccct atctgagatt acaggctgga cgctgaacag tgaagatcag aaagatatca 980761 atactatatt ggaaaatacg atatcagacc ctgtcggacc ggagtttatg gccccgccga 980821 ccagagagga aatataacaa aagctgaggg cgaatcctca gctttttggc gtttaaacga 980881 gagaaatctt aaaaattagt accaggtaat aaaaaatatt gttataatag atgacagaaa 980941 gaatcattga ttacgacaaa ggaagtgcga tatgtataag ttttgtgcaa atgctttaaa 981001 agttattctt tctcttcgcg gaggagtgaa ggtgtataac aaagaaaacc ttccggccga 981061 ttcaggtttt gtcatcgcgt gtacacattc cggctgggtt gatgtgatta cactcggagt 981121 cgggattctt ccttatcaaa tacactacat ggcgaaaaaa gagctttttc aaaataaatg 981181 gatcggttcg tttctgaaga aaattcatgc ctttccggta gatcgggaaa atcccgggcc 981241 aagcagtatt aaaacgccga ttaagctgct gaaagaagga gagatcgtcg gtatcttccc 981301 aagcggaaca agaacctctg aggatgtgcc tttgaaaaga ggtgcggtga cgattgcgca 981361 aatggggaaa gcgccgcttg tccccgctgc atatcagggc ccttcaagcg gaaaagaatt 981421 attcaaaaaa ggaaaaatga agctgattat cggtgagcct cttcaccagg ctgattttgc 981481 ccacctgcct tcaaaggaaa gacttgcagc aatgacagag gctttgaatc agcggattaa 981541 agaactagag aataaacttg atcagctata aggcgttctg agagattgtc ctgaaactgt 981601 gaaaataaga aaagcaccct atacaaggtg cttttcttat tatgcttcct gctggttagc 981661 tgtctccaga agttcttctt cttgaagctt tttcacttca atatatgcga cgtggtggcc 981721 gtcaatttca ttaatgatga attcgcagcc ctcttcgatg atggaatcat ctttttcaac 981781 atcgtatttt tgagtaagga accagccgcc gattgtatcg acttcttcgt tctctaaatg 981841 gatgcctagc aggtcgttta cttggtcaat taacactttt ccgtcaagaa tataatggcc 981901 ttcgccgatt ttgcggattt cgctaatttc atcaatatca aattcgtcgc ggatttcacc 981961 gacaatttcc tcaatgatgt cctcaaccgt cacaagcccg gcagtaccgc cgtattcatc 982021 agacaaaatg gccatgtgga ccctctcttt ttgcattttg acaagcaggt cttggatcgg 982081 cgcagattca atgacatgaa tgatagggtt gacgaattga gaaatggtgg aatcaacaga 982141 tacctcaccg ctgatgcagg cggtcagcac ttctttaatg ttaataaccc cgataatgtt 982201 atctttatcg ccctcttcca cagggtagcg ggtatatttt tcaatctgaa tgatgtccat 982261 catttcagaa atcttgatat catgcggaag gctgacaatt tcggtccgcg gaatcataat 982321 ttctttcgcg agcctgtcgt caaattcaaa gattttattc acatatttaa actctgattg 982381 gttgatttca ccgcttttat agctttcaga caaaatgatt cgcagctctt cttctgagtg 982441 agccagttcg ttttctgaaa cggtctccag gccaaatgct ttggtcaata accgtgcgga 982501 attgttcaaa agccaaatga atgggaacgc gatgcggtaa aaccaaatca gcggtttcgc 982561 aaacagcata gacactgctt ccgccttttg gatagcgact gttttaggtg caagttctcc 982621 gacaacaacg tgtaagaacg tgataatggc atacgcaaaa ataaacgata tgacatgtga 982681 aagggaacct ggaacgttca tttggacgaa aagcgggtga agcagccttt cgatcgttga 982741 ttcacctaaa acccctaatc cgatggaagt caatgtaatt ccgagctgac acgcagataa 982801 atattcatca agatgcgtgg tcactttttt tacggctatt gctgctttat ttccttccgc 982861 gatcagctga tcgatccgtg agcctctgat tctgataatg gcaaactcag atgccacgaa 982921 aaatgccgtc agggcgatta aaacagcaac taaaatcaaa ttcactatgt ccaattagaa 982981 ccttcactct agcaatgaga atgaaggtaa cacctcctgt tagataaaat ggttttaact 983041 taacagcagc ataaatgatt ggaacacggc gagcttttca ggcgggagtt tgcttttcag 983101 cttgtcacga tcctcgggct tcagccgttc aaaccgatgc aagattccgg agatgttttg 983161 attcatatga tcaatttcta atgccagatt tccaatttca tcatcaagtt tagctgaaga 983221 gggaaactgg ttctccagtc gatctttaat atcggacagg gccaatcgct gcttcttgca 983281 atctacaata aatataagtc gtttgagtgc attttcgtcg tagtaacggt aatttgaaca 983341 ggatctggcc ggcgtaagca gaccgagatt cgtataataa tcaactgtcc gtttcgttac 983401 tccggcgagt gccgctagtt cactgatgcg ataagtctca gccccatcta tatccctccc 983461 aaccatcacg ttatagttat gagaatagtt taatatatga acggtgtctt gcacaagttt 983521 attgtttttt ttagaccgga attggaagtt gtggaattca tcatctgatt gaagtaacat 983581 aggaagatag aattttcaaa tttttatatg cggaagggac agatgaaatt ggctgggtta 983641 tcccgggaag ttgaagaaaa cttaaataaa ggatcatgga ttcgcaagct gtttgatgaa 983701 ggtgcaaggc tgaagaagga gttcggggaa gaccaggtat ttgatttttc actcggcaac 983761 ccgattgttg aaccgcctga agcttttaag agagcgttaa tagaggaagc tgaaaaaggc 983821 agccacggat acatacaaaa ccaagggctt cttgcagcga gagaaaaagt cgcgcaattt 983881 ctgggctcgc gttttgaagc tgatttctca gcggagcgca tcgtcatgac ggtgggcgcg 983941 ggaggcgctt tgaatgttgc gttaaaaagc atcgtaaacc ctggggaaga ggtcattatt 984001 cttgcacctt attttgccga atataagttg tatattgaga actacggggg aaaagccgtc 984061 agctgcccgt tgacaagccg gtttgagatc gacattgaag cggtaaggca atcgatcact 984121 ccacagacga aagggctgat tctcaataca ccgcataacc ccacaggcac tgttctcagc 984181 cagaaaaata tagacgattt aggcgcttta ttaaaagaaa tagaagagaa gagcggccag 984241 acgatttatg tgctgtttga tgaaccgtac agtcaattaa tctatgatga agagctggca 984301 aatccgtttc aatcgtacca tcgtgtgata ttggccagct cattcagtaa agatctcggc 984361 atagccggag agcggctcgg gtatatcgga ttggacagcc gaatgccgga tgcggacctt 984421 ttgatcaacg cttttgtgta ttgtaatcga acgcttggat ttgtgaatgc ccctgtcatg 984481 atgcagcggg ctgtggcacg aatggatgat ttaagagtag acgcgagcgc ttataaagag 984541 cgccgggatt taatggtaga cattttaaaa gaagccggtt ttgaatttga aatgccaaag 984601 ggaggtttct ttgtttttcc gaaatcgccg attgaagatg aagttgcatt ttgcgtgcat 984661 gccgcccaaa aatacaaatt attaattgtg ccgagcagcg gttttggaat gagcgggcat 984721 ttccgattat ccttcagtgt gccgatcgag cagattaaaa actcacggga cattttcatt 984781 tctttatata aagattttgc ttaagaaggc aaagaaaaga aaacagtttt caaggctgtt 984841 ttctttttat atccgcaaaa tccttcctct tccaatccag acaggcgcag aattgacaag 984901 caggcatgca gttaaggctt tcttcatgat aaaagtctaa aaattaaaaa tcatttttgg 984961 aatgagttgt gttacaataa aatatacaat ttataatcaa actttgactt ttggaggtgg 985021 tatgatgggg ccctctgctt aggcaacaat acaccgcgta cctcaatgtt aaggaaaaat 985081 gattatatca ggaggtgact ccttatcctt tgttgagagg atagggttaa atggacgata 985141 ttgacagtct gattttaatt ggcgtgctca ttgctttaac cgcgtttttc gttgcaagcg 985201 agtttgcgat tgttagagtg aggagatcca gaatagatca gcttatcaca gaaggaaaca 985261 aacgggcgat actcgcaagg cgtgtcatta cagatttgga tgaatattta tccgcatccc 985321 agctaggcat tacattgaca tcaatcgggc ttggcgtact gggtgagccg gcctttgaac 985381 ggctgctgca tccactgttt gaaccgctcg gcttgccgga ctcggtttca catgcagtct 985441 cttttgcagt cgcgtacggc ttgatcacgt tcctgcacgt tgttgtaggt gaactggccc 985501 cgaaaacggt cgcgattcaa aaggcagaac agctgacttt actgatagcg ggccctttgc 985561 gtttattcta tttgctcctg tttccgttta tttggatcct caatggatcg gcgcggcttt 985621 tatgcgggat gttcggtttg aagcctgcgt cagaacatga tggttcccat tctgaggaag 985681 aactcaggat gctgttatct gagagtttaa aaaacggaga gattaatccg tctgaatata 985741 aatatgtgaa taagattttt gaatttgata atcggatcgc caaagaaatt atgataccgc 985801 ggaaggaaat ggctgctgtg tcaactgaga tgacgatggc cgagatgctt gaagtcatgc 985861 tgaaggaaaa atacacgcgc tggccagtca cagatggaga caaagacagt gtgctcggtt 985921 tggtcaatac gaagcatttg ttttctgatt tgctgtttat gacagaagaa gaacgaatga 985981 agatgacgat ccatccgtat gtgaggccgg tcatcgaagt gattgaaacg atcccggttc 986041 atgacttgct gattaaaatg cagcgcgagc gcattcatat ggctatattg tcggatgaat 986101 acggaggaac ctcgggactt gtgacgacag aggatattct tgaggaaatt gtcggagaga 986161 tccgagatga atttgatgaa gatgaacagc cgctgatcca aaagcttggc gacggccatt 986221 atgtgatgga tggaaaggtt cggatcgatc aggtgaacag ccttcttggc gcatcgattc 986281 aagaagacgt cgatacgatc ggcgggctga tattaaaaga aaacatcgat attgaggctg 986341 gtgaatccat tcgcatcggt tcatatacga taaaggtgct gaagatggac ggccgattaa 986401 tcaagcaaat cgatataaaa gaagaagccg gcaacacaac cgggattacg gcgcaccaca 986461 agctgccgct gcccgagcct gtgatgctga acagtgcaac cttgagcgag aaataagctc 986521 aaggtttttt tatattgtga ttgtccagcc gcaccaaaat gcaaaaagcg acccgcaaag 986581 tgtcaggacg atgtacaaga tgctttcttt tacacgtttg gccataagga gttgaatagt 986641 ttcaacgctg aatgtggaaa aggtcgtaaa ggcgccaaaa aaccccgtgc caatgataag 986701 cgagaccgaa gcatttgcaa cgtgaagtcc tgtaaatatt ccgagcccga gagctccgag 986761 aatattgact gtcagtatgc caatgggcag gctgagacct ttggttttgg cggttatgac 986821 attgccaagc cagaagcgaa gcattgcgcc aagtccgccc cctatgaaaa tacccgctag 986881 tgtcattttt cctgcagccc ctttctttgc tgaatgcctg ctatgcgccg tcccacaaaa 986941 acaccaatca gtgcaaatat gatccctgat atcaatgagg ctgccacata taaaagagcc 987001 aatgagggtt gtccttgcaa aagcatcact gtttccttag aaaacgtgga cattgttgtg 987061 aagcctccgc aaaagccggt gcctaaaaaa gccgacagca gaggccgttt tgccccgatc 987121 ataaaaaatc cggtcaaaat gcctaataga aggctgcctg ccgcattttc cagccaggtt 987181 gccgccggga actgaccggt gtgtatccat aagtttaatc cgtatcggag gcaggcgcca 987241 agcgcgcctc cgataaaaac cgcgctatat attttcatgt ttgccatcct ttatgatgaa 987301 atccgggtaa tctgtaacga tgccgtccac gcccatggct tgtaattttg ccgctgtctt 987361 ttgattgttg acagtccatg caaatatgtt taagccattt ttattgatgg agccgatcat 987421 cagacggtta agccgtgtgt gttttatatt gacatagttt gcaaaagagc ggaaggcctt 987481 catctgattt ctggacagca tgccaaagtt gggccttgta atgaccgctg tcggaatcga 987541 aggataaagc tcgcggaacc tttggacgga gcggaactga aaggattgaa caatattatt 987601 gatagaaaaa gaaaattgcc ctaatagctg tcccacctct tcttcaattc cgacttgaga 987661 cggatggcct tttagttcaa ttaaaaggcc gatttttttg tggtagcgct tgagcaccgc 987721 ttccagggtt ggaatacgct ctccttgaaa agcgggaccg taccagcttc ctgcatcgag 987781 tttttgcaat tcctccaagg taaaatcctt aacaaagccc gatccgtttg ttgttcggtc 987841 aaccctgtca tcgtgtatca caacaatctg cctgtctttt gtaagctgga catccagttc 987901 gatcatatct gcattcattt tcaccgcaag gtcaaatgcg gcaatcgtat tttccggagc 987961 gtagccggat gctccgcgat gggcaatgat gtacaagcta agtcagctcc tcgtatgggc 988021 atttctgtta ttgtatcaaa tccatatatg caccgcgata caaactggtg aattttttct 988081 gccatatcgg aatggtccgg gctgaggaat gcgtataact aaaaaaagac actcagcgta 988141 tcagaacaca tttcgtcaga aaattaggtc tttcgacatg ttcacaacaa aatatgatcc 988201 tttataatag caaaaaagga ggcgagatca tgggaaaagg gagaatcaga gtggaggaaa 988261 gaattaaagc cgaaacggat gctgaaatgc aaaaagcaac tctccttgat cagacacaaa 988321 cgaaaaaagg taagtgactg tccctattga atctggctga tagatgaatt gagaaatgac 988381 cccggcgttt cgccggggtt ttgtgctgca taagacattt aaatgaacat ccttacgaat 988441 attttagtat aataaacaat tgattgggat agaggggaga cagtcatgcc ggattatctg 988501 cagcagtatt ttacgcttga taacatcata caaatcggca tcagcttggc gattttgctg 988561 gtgtttctta tacttagaaa attattcaca agatattttt ttaacctgct ttttaatttg 988621 acaaaccggc cgaaaacaga aatttttaaa caggtggttc tggcgtttga taagccggcc 988681 agatggtttt ttgttgccct tgggctgttt ttagcgatcc ggtattcacc gtttttagat 988741 gagcaaatgc cggtcatcag caaaatatac cgctcactga ttgtggcgct cttgtgttgg 988801 ggtctttgta atttgaccgc aacatcgtcg tttatcttcc ataaggtgaa ccagcgcttc 988861 gagcttgaca tggatgacat tctggccccg tttttatcca aattgctccg ttttgtgatc 988921 attgcgctca gtgtcagtgt gatcgctcag gaattcaatt atgatgtcaa cggatttgta 988981 gcgggccttg gtcttggcgg actggctttt gcgcttgccg cgaaggatac catcagcaac 989041 ttcttcggcg gtattatcat tattactgaa aagccgttta caattggtga ctgggtggag 989101 acgtcgacag taacaggatc agtcgaggat attaccttta ggagcacgag attcagaaca 989161 gcacaggggg cgcttgtaac ggtgccgaac tctacgctgt cgatggaagc gatcacgaac 989221 tggacaagaa tgaccaaacg ccagattacg ttttccatcc atgtgtccta cgctacgccg 989281 attgagaacc ttgaacgctc cattcattct ctcagaacaa tgctcttaga gcatgagggc 989341 gttgataatg aaataatcat ggtcaacttt gatacgtttg ccgacagcta ctacaattta 989401 ttttttaact tctatacaaa aacgacggtt tgggctgaaa accttaatat tagagaggat 989461 atcaactata aaattattga gattttaggt gcagaaggcg ttcagtttgc atatcccggc 989521 caaatggttg ttgtcaagca aaagcacgaa agcgaccaat tccaggtgaa tctaaataaa 989581 gaggaaaagg aacgggctta aaagagagac ttcgtctgac agaggcggag tctttttcat 989641 ggtaaaataa gagaaaaagg cggtgttgag ttggaaacat tcaaaagtat tctacatgaa 989701 gcacagagaa ttgttgtgct gaccggagcg ggaatgagca cagaatcagg gatccccgac 989761 tttcgttcag cagggggcat ttggacggag gatgcctcaa gaatggaagc gatgagcctt 989821 gattattttt taagttatcc gcgtctgttt tggcccaaat tcaaagaatt gttccagatg 989881 aaaatgagcg gcagctttga accgaatgaa ggccatttgc ttttagctga gctggagaag 989941 caagggaagc aggtcgatat tttcacgcaa aacattgacg gtcttcataa aaaagcgggg 990001 agcaggcatg tgtacgaact gcatggttct atccagacag cagcttgtcc ggcatgcggc 990061 gcccgatatg atcttcccca tttgctggag cgggaggtgc cggagtgcac ggcggccgga 990121 aacaatgggg acatttgcgg aacggtatta aaaaccgatg ttgttctctt tggcgatgcc 990181 gtcatgcact ttgacaccct ttatgaaaag ctggatcaag cagatctttt attggttatc 990241 ggcacgtctc tcgaagtggc tccggctaga tttgtgcctg aggatgcaag cctgattccc 990301 ggcatgaaga aagtcatcat aaaccttgaa ccaacgtatt gcgacagctt gtttgacatg 990361 gtcatccatc aaaaaatcgg cgagtttgcc cgaagtttgg gcatgaaaaa gtgagccgct 990421 ttatgcgcct cactttttta ttcatgaaca ggaaccattg tgtcctctaa cactccgaag 990481 gaatagcctt tttcttttaa tttattgatt agtaccggca gcgcatttac agtagcagga 990541 agatcatgca tgagaattac atttgggcgg cttgaagagc tgtgttccat attctcaagc 990601 tgctgtaata cggcggtcac atactgtgaa ttccggtatt tccagtccat gctgtcgatc 990661 gtccaatccc agtacacaaa cccatctttc tccagattgc gaatttgtga ggcggttagt 990721 gacggcttgc ttccgtatgg cgttctgaca agatcggttt tatatcctgt aatgtcctgc 990781 agcgtgtcac gcgcctcctg catttctttt agcggagatg tcggtgtttg atagaacaat 990841 ctgttattgt gggtaacgcc atgtaaaccg agtgcgtggc cttccttttc tgctcttttc 990901 acagcctgct tgaattcgtt catccgcggt gacagcataa aaaacgtcgc ttttacatca 990961 gcgcttttca gtacgtcgag caagcgggtt gtaacggctg aagggccgtc gtcgaaggtt 991021 aagtaaaccg ttttatctcc catgttctgc tttgtctgca gatgttttat caggagatcg 991081 ggggagtcgt ttttcagctt aaggctttcc ttctcatctc gaagctggcc gtttgttgtg 991141 acagtgactt cctttgcttt cgttgaactg ttggaataac ccaaaatcac cataagcaaa 991201 agcagcacac ataaaactgc taaacttgca aatttaaaag caagcgaaac tgcagaagga 991261 gaagcctctc ctctcgtttg tcgcataaca atctctccat tggcataaaa tctctacata 991321 atgctgtaca gcaggcagct tatgaagatg ccttatgttt acaacctatg tattaccagt 991381 caagtataca ggaataaaac tggaaagcac atagaaaatt tgtcgaaatg tcagatttta 991441 aggaaaaaat aaactccttt ccgctataga tctcttgatc tttctgtttt tcagcttgtc 991501 caatatggta gaattagtga taatgacagc ttgaatgaca tcagggacat ctcgaaaagg 991561 gagggctttt atgaaggttt tagtcaatgg ccggctgatt gggcgcagtg aagcatcaat 991621 cgatttggaa gatcgcggtt atcagtttgg tgacggcatc tatgaagtga tcagggtgta 991681 caaaggagta ttgttcggct tacgtgagca tgcagagcgt tttttcagaa gtgctgctga 991741 aatcggaatt tcactgccat tcagtataga agatctcgag tgggacctgc aaaagcttgt 991801 acaggaaaat gcggtcagtg agggagcggt atacattcag acaacaagag gtgtggcccc 991861 gcgaaaacac cagtatgaag ccggcctcga gccgcagact actgcctata cgtttacggt 991921 gaaaaaaccg gagcaagagc aggcatacgg agtggcggcc attacagatg aggatcttcg 991981 ctggttaaga tgtgatatca aaagtctgaa tttactgtat aatgtcatga cgaagcaaag 992041 ggcctatgaa gccggagcat ttgaagccat tttacttagg gacggcgttg ttacggaggg 992101 tacatcctct aacgtttatg ccgttatcaa cggcacagtg cgaacacatc cggctaatcg 992161 gctcattctc aatggaatta cacggatgaa tattttagga ctgattgaga agaatgggat 992221 caaactggat gagactcctg tcagtgaaga agagttgaaa caggcggaag agatctttat 992281 ttcgtcaacg acggcagaaa ttattccggt cgtgacgctc gatggacaat cgatcggaag 992341 cgggaaaccc ggaccggtga ccaaacagct tcaggctgct tttcaagaaa gcattcaaca 992401 ggctgctagc atttcataaa tgaacgaaga aaagagcccg ctttttacag cggggctctt 992461 tttatttttt aacaaatcca atcaaaatgg agatcattgg cgatatatag aggaagaacg 992521 taaatgggat gtagtctatg actggaacac caagtgcgct cgccataaat gcgccgctga 992581 cgccccaagg aatcaatggg ttaattaatg ttccgccgtc ctctaatgat cttgtcagaa 992641 attttcgctg gatgtttcgt ttgtcatata aagatttaaa tgattgtccc ggtattaata 992701 tcgataaata ctgttcgccc gttgccaagt tgacgccgat gcttgagcag acagttgctg 992761 caacaagacg gccttttgag cggatgcctt tcatgacgcc ttccaatagt gcagaaatca 992821 atccgatttt ctccatcaat ccgccgagtg caaaagcaat cataatgaga gagacagagc 992881 ccatcatgga ttgcagtccg cctctgttaa taattttagc ggctgcctca ttgtcagttt 992941 cgaaagttgt gccattttgt aaagctgtca taaacgcctg caggctgctg tagggtacaa 993001 aaatagcagt caaaattccc gaggaaataa ttccggcagt cagaacgggg attactgata 993061 cccgtttcat tgccagcaaa acgactaaga gcggagaaag aagggcccac ggtgtcacgt 993121 ttgcagcatc ttttattccg gttatgacct gctgaatatt atcggttgaa gcagcgtccg 993181 ctgacactga tgaaccgaga aagtaaaaca gaacgacagt gatgagcaaa gctggaatgg 993241 ttgtgcccat catatggcga atgtgttcaa agattggtat ttcgcctatt ccggctgcaa 993301 agttggttgt gtccgacatc ggcgacattt tatccccaaa acaagcgccg catatgactg 993361 cgcctgctgt ccattcaagc ggaacgccag ccgcgctcgc cacgccgatc agcgctactc 993421 cgattgtgct tacagttgtc agacttgagc caacaagtgt gctgatgatc atacatgaaa 993481 acaaagcagt caacagaagg tggcttggtt caataaagga tagggcataa actgtcatag 993541 tcggtattgc gccgctgtac atccaggcgc cgattaagat gccgatcagc gctagaacaa 993601 taatcggctg tacgccgttt ttgatcccgt ctacaatccc tttttcaatg ctcttccagg 993661 gaaatccaaa ccataaagct gctgctgaaa gcatgacaac acttaaaaac agcgggatat 993721 gaggttctac atgaagcaag aataagcaag aaataataat gcacaacatg aatataaata 993781 aaccgacggc taacggaaac gtcagctttt tttgagaatc caaaataaca ccccatattt 993841 atctttaatg cttttgtgct tttgggcacg aaagcattat aacagaaaaa aacgaaaatc 993901 tatgtttttt cacaattatg aatataaaag aagtgagcac agggcgtgct cactttacaa 993961 tcaggacggg tatatccgat ttcgctgaaa gcttttcact tacacttccg aatattagct 994021 ttttcagcct gttttggtct ctgcttccgg ttacgatcat atcggcagaa atgcggtttg 994081 catgctcgat aattgattca gccggatcgc cttctaatat atcgatatct ccatctgcct 994141 gctgttcatt cagcatcatt ctggcttcgg cgatgacttc ttccgtacgg tcttcataga 994201 tcattggctc aggtgatgtt acatccgata tcagcggatc aggaacactt gtcatgcctc 994261 cgctgatata gcttgcctca gctgcgggtc tgggcgggtc gatgacggtc tgattgtctt 994321 tcatatcatg tgaatgggcg acggtaatag cggcatttac ggttttagca agatcaatgg 994381 ctgtcagaag cgctttctta ctattttcac ttccgtcaaa cgcaacaatg atacggtcag 994441 catggaacat ccttctcacc ctttcaaagc gtcttacaac actactaccc gaatttgagc 994501 acaattaacc ttttcctatt caagtaatga ttgacaataa aaggttttgt ttatatgatg 994561 ataaaaagat gaaatcagaa tggaaggagg gtttgctatg ccaaggaatt tgcgtgttta 994621 tcaaacagtt tcatattggc gcggcaaacc ttttgttctg ttttcgtgaa cggtttttta 994681 ggtcggaccg cgcgctgaaa agcgctgtgc gtaacatatc ggttaaaaaa ggcatggagc 994741 tgacgcttca tgcctttttt atatacaaaa tctaaggaaa gacaggtgta tgggatgtga 994801 agacaaatac agaggcgagg gcagttcgtg ccaaactgga tgaaaaaagc tgcaaggaaa 994861 aaatagaagg cggctgatga ggagatgggg atagatgttt tcagttttga aaaagcttgg 994921 ctggtttttt aaggcgtact ggctgcgcta tacgattgcg attgtccttt tattagcagt 994981 caatgtcatt gaaatgtttc cgcctaagct cttggggaac gccatagatg atatgaaagc 995041 aggggcattt actgcggaag ggctgctgtt ttatatcggt atcttttttg tgctgacggc 995101 ggccgtgtat atcatgtctt atttttggat gcatcagctg tttggcggag cgaatctgat 995161 ggagaaaatt cttcgtacga agctgatggg gcatttgctg actatgtcgc cgccgtttta 995221 tgaaaaaaac cgaacaggcg atttaatggc acgagggaca aatgatcttc aggccgtcag 995281 tttaaccaca gggtttggca tcttgacgtt agttgattct acgatgttta tgatgacgat 995341 ctttttgaca atggggtttt tgatcagctg gaagctgacc tttgccgcca ttatcccgct 995401 tccagtcatg gcgattgcaa tcagtctata tggaagtaaa attcatgagc ggtttactga 995461 ggcccaaaac gcgttcgggg cgctgaatga cagagtgctg gaatctgttt caggcgtgcg 995521 ggtgattcgc gcgtatgttc aggaaacaaa cgatgttcgc cggtttaatg aaatgaccgc 995581 tgatgtttat cagaaaaata tgaaagtggc ttttattgat tcactgtttg agccgacggt 995641 aaaactgctt gtcggcgcaa gctatctgat tgggctcggc tacggagcgt ttcttgtatt 995701 ccggaacgag ctgacgcttg gagagttagt gtcctttaac gtttatctcg gcatgatgat 995761 ttggccgatg tttgcaatcg gtgaactcat taatgtgatg cagcgcggca atgcgtcatt 995821 agatcgggta aatgaaactc tttcttatga aacggatgtg acagatccaa aacagcccgc 995881 tgatcttaaa gagcctggag atatcgtttt cagtcatgtc agctttacat atccaagctc 995941 aacaagtgac aatcttcagg atatttcatt tacggtgcga aaagggcaga ctgtcgggat 996001 tgcaggtaaa accgggagcg gaaaaacgac aattattaag cagcttttgc gccagtatcc 996061 tccaggtgaa gggagcatta cattttcagg tgtaccgatt cagcaaatcc ctcttgaccg 996121 tctccgcgga tggatcggat atgtgcctca ggatcattta ctgttttcac ggactgtaaa 996181 agaaaatatt ttatacggaa aacaggatgc aactgataaa gaggttcagc aagccattgc 996241 cgaagcacat tttgaaaaag atttgcacat gcttccgtcc ggtctggaga caatggtcgg 996301 tgaaaaaggc gtggcactgt caggcgggca gaaacaaaga atttcgatcg cgagagcact 996361 catggcgaat ccggaaatct tgattctgga tgattcactt tccgctgtag atgccaaaac 996421 agaggctgca attatcaaga acatcagaga aaaccgcaaa ggaaaaacga catttatttt 996481 gacacaccga ttatccgcgg tagagcacgc tgacctgatc cttgtgatgg acggcggcgt 996541 cattgctgag agaggcacgc atcaagaact gctggccaat aatgggtggt accgggaaca 996601 atatgaaaga cagcagctgt tcactgcgga agaaggggga gcaggggcat gaaaatagga 996661 aaaacgttat ggagatacgc acttctttat cgaaaattgc tgatcacagc cgtccttttg 996721 ctaactgttg ccgtcggtgc agaactgact gggcccttta ttggcaaaaa aatgatagac 996781 gaccatatcc tcggcattga gaaaacatgg tatgaagctg cggaaaaaga taaaaatgcc 996841 gttcagtttc acggcgtctc atatgtcaga gaggaccgat tgcaggagcc tgtttcaaaa 996901 gcaaaagaag cgcatattta tcaagtggga atggcgttct attttgttga tcaggctgtc 996961 agcttcgacg ggaatagaac ggtttctgac gggaagctga cgatcacaaa cggagacaag 997021 agccgggcat atgctgccga aaagctgact aagcaggaac ttttccagtt ctatcagccg 997081 gaaataaagg gaatggtgtt actgatctgc ctgtatgggg gcttgcttgt gttttcggta 997141 ttctttcaat acggacagca ttatctgctg cagatgagcg ccaatcggat tattcaaaag 997201 atgaggcagg acgtgttttc gcacatacag aaaatgccga ttcgctattt tgacaacctt 997261 ccggccggaa aagtcgttgc gcggattacc aatgatacgg aggctattag ggatttatat 997321 gtcacagtgc tttcaacatt tgtgacaagc ggaatctata tgttcgggat attcacggct 997381 ttgtttctgc ttgatgtgaa gcttgcgttt gtatgtctgg caattgtgcc gattatctgg 997441 ctgtggtcgg tcatataccg gagatatgcg tcatattaca accaaaaaat ccgctcgatc 997501 aacagtgaca ttaacgcaaa aatgaatgag tcaattcaag gcatgaccat tattcaggct 997561 ttccgccatc aaaaggaaac aatgagagaa tttgaggaat taaatgaatc acatttttat 997621 ttccaaaaca ggatgctgaa tttaaactcc ttaatgtccc ataatctggt caatgtcatc 997681 cgcaatcttg cgttcgtctg tctgatctgg cattttggcg gtgcgagcct gaatgcggcg 997741 gggattgttt ctatcggtgt gctgtacgcg tttgtcgatt atttgaaccg gttatttcag 997801 ccgatcacag gcatcgtcaa tcagttttca aagctggagc ttgcaagggt ctccgccggg 997861 cgtgtttttg aactgcttga agaaaagaat acggaagaag cgggtgaacc ggcgaaggag 997921 cgcgcgctgg ggcgggttga atttcgtgat gtgtcatttg cgtatcaaga aggtgaagag 997981 gtattaaagc atatttcctt tactgcgcaa aaaggcgaaa ccgtagcgct cgtcggccat 998041 accggatcag gaaaaagctc gattttgaat cttctgtttc gtttttatga tgcgcaaaaa 998101 ggtgatgtct taattgatgg aaaaagcatt tacaacatgt caagacagga actcagatcc 998161 catatgggta ttgtgcttca ggacccgtac ttattctcgg gcacaatcgg atctaacgta 998221 agtctggatg acgaaagaat gactgaagaa gaaataaaaa atgcactgcg gcaagtcggt 998281 gctgagcctc ttcttaagaa gcttccgaag ggcattaatg agcccgtgat tgaaaaaggc 998341 agcacgctat cctctggaga gcggcagtta atttctttcg ctagagcttt ggcgtttgat 998401 cccgcgatct tgattttaga tgaggcaacg gcgcatattg atacagagac agaggccgtg 998461 atccagaagg cgcttgatgt cgtcaaacaa ggacgcacca ccttcgtcat cgctcaccgg 998521 ctttcaacaa tcagaaatgc tgatcagatt ttggttcttg ataaaggaga aattgttgag 998581 agagggaacc acgaggaact gatggcatta gaaggccaat attatcaaat gtatgaactg 998641 caaaagggac agaaacattc cattgcataa cgctcaaaaa cccaaaacaa tcgtgttttg 998701 ggtttttggt ttatgtagtc aataagccag tccgacacgg tttccgacat actcacctgt 998761 aacgagctca cgatataaaa agtccgcagt atcgccgacc gaaatgcttg tgccgccctc 998821 aggcaaaacg ttacgctccg tacgataaac gccggttgct gttccgtccg ggaggtaagt 998881 ggggcagatg attgtccagt ctaatgatga ttctttaagc atttcgtata cttttgcatg 998941 ctccttggct gcgcgggtct gctttcgttt cgattcattt gtttcaaacc ggtattttcc 999001 cggttcatat cgggaatcta ggatccctgc ggtgccgatc gtaataagcc gtttgatatg 999061 ctgttcctcc ataacggaga gaatgtgtgc catagcagtt gacaaggtat catcaccatc 999121 tgtgcctaga cagctgatca cgatttcagc attctccatt atttttttca catcttctaa 999181 gcggcgggcg ttccccatga cagttctgtc ttttgaaagg ggaagatcag catgttgaga 999241 tctgatcaga gcgaaaatat caaatctttc atctgctgca gcttgtgtta aaaaggcttg 999301 tccgacgcgg ccgctggctc ctaataaagc gattttcatt aaaaaacctc ctcgcctttc 999361 attataaaag gatgttctca gtttgaacag cgcgggaaag aatacctgta caaataaaca 999421 gaacgatggg aaacatattc atgaatcatg gatacactta cgaattgaac cagctcccaa 999481 ttcacaatgg tgatgaatga caccccgatt ccctcccttt ttttctagga tatgtggagc 999541 aggaaaaaag ggtgacaaaa taaagagagc gcggaaaccg cgccctctat agccatatat 999601 tgaattgtta ttgaactctg ccgcccattt gctgctgagc gaaagatact aaacgttttg 999661 tgatttctcc tccgacagaa ccgttagcgc gagaagttgt gtccgctcca aggttaacgc 999721 cgaattcaga agcgatttca agtttcattt gatcgatagc ctgagctgcg ccaggaacta 999781 gtaagtcatt tgaagagttt tggttagcca tgtgtaaaat ctccttttta tttagtatgg 999841 ttgggttaac tggagttgca ccaatctgtg aacccttctc gggtgtcact gccgcctcgg 999901 cgtaacccaa tgctttgccg gcttgttact acgtattatg ttaaaatggc cggaaaatca 999961 tgcggagaat tgtgtggtaa atcttgagaa ataaaaaaag cttagccgtt taggctaagc 1000021 tagtcataaa tatgaaaaag catcagttca tgtatctcgt ttgtaagagc aggctcgtca 1000081 gcgcgggcgg gaaacaagtc tccccattca atctcaccgc tcttatgata gatgccttca 1000141 taatgggtcc ctttataata aaatgaaatt ttccatccgg gcagcttttc ttttgggaac 1000201 aaaggtttcc agctgaaatg agaaatcatt acggccacgc tccttacatt tggtatcaat 1000261 tgacctaaat aaaaacggct tatgttcatt gtatcattgt ttcagaacat cattgaagag 1000321 gcctaaatat gcagtttgtc ccagctttgg ataaagataa gcccgcttta ttaaaaaagc 1000381 ggacaggtta cgaaggccac aatgcttccg gagatgtgat tgccttctca gataaatatg 1000441 acgcgtattc aaaacttctt cgttttgtaa gagaatcaac atgatgcaaa tttggatgag 1000501 aaaaaatgct tcggcccggg cgcgaattcg cttcaaacat ccatacttta ccgttctgat 1000561 caatgccaaa atcgaaacca atctccccga taaatccctc gatatgatca tgaaggacat 1000621 ggcttgcagt cagtgccgct gcagaaagct ttttaatgac ctcaactctt tcagcgggat 1000681 catcgtatac ttccgcaagt gtctttacag tgccgccgtt agaaagatgt gttgtaatgc 1000741 tgttctttcc ggaaattttt acggcgattg ctgtcactgt ccattttcct tttctgtttt 1000801 tattggtatg gacacggaaa tccgctggtt tgccttgaaa ttcgatgaga tcaacacctt 1000861 gctgaatgag aaagtcggac gggttgtgat gtttttgaaa ttctgcaagg aatgaggcgg 1000921 catcggaata atcaattgat gtaaaagttt tggcgtcatt cgtatgcttt accgtcaggc 1000981 cgccatctgt tcttgtcagc tgataaatgc cggtgccgag tgctccattt gccggtttga 1001041 tatagacttt tttgtatgcg ccacagagct catctatcag ctccacagac ggtgtcagct 1001101 cggatctagg caaaaagggt gccgttcttg gatctttttc gagcaattga tgaacgttcc 1001161 atttattgaa aaacgtttta ttaaaccatg ggatctgata ttcatcgatc agcctctttt 1001221 ttgtatgttg caagagaagt gaatcttcaa tttttcggtt cggcaaacgg tcataaacga 1001281 cgttcggcaa tggaacgatt tttttctccc agccgttttc cctgtaaagg aggccttcaa 1001341 tcgtgccttc ctcccaattg atttggtgcg cgccaaaaac gaagcagtag cccccggctt 1001401 gctcgtgtaa cgtgacaagt ttagaaaaaa agagggaacg atccttaaat gggcgttcaa 1001461 gagatacagt aaaccctgcc gtaaagatgc cgactaacgg cccgatatgc actgtatgat 1001521 catgaatcag tatatctgcc ctgcttcggt ggggaagcaa aagctcatga aacagatttt 1001581 cagagagaag cacggtttgt tccagatgcc gtctgtaagc aacgtggcat ctgacaacct 1001641 tcgttccgaa tgcggcatgc aaaagtccgt cttgcttcag cgaagagggc agaaacaggg 1001701 tgttttcact ggttttgtct atgccgatca aaaaccgttt aggattcacg cggaagaact 1001761 cctttctggc tttgctcaga aaacagatat tggcagcgtt ttaggggaca agtgtacagc 1001821 tgttcttttt gctcgggaga gacacgcagg attgacttcc tgcctggttt ggaattgata 1001881 tctaaaatcc aaattctccc gtcctttgca agacatatat caagaccgag ttcaaacaac 1001941 ggcccatagc gctcgtcaag ataatacgga accgattggg taattgaaaa cacatcatct 1002001 agtaaaacca cttgctgttt tttcggtata tcttcaaacc aggagtcaaa tgtcagcgca 1002061 tcagatccgc ctgacaaatt ggccagcagc ccgtgtttgt atccgcgtct tactgccttt 1002121 ccgactgtat tccattcacc tgcttcgttt ttttccataa acagacgaat atcacaaggg 1002181 tattgttcct tatcttgaat gtttaagtaa ggctgaagca aatattgatg ctgaagcact 1002241 tttttgcacc atgttttaaa agaagtctgg ttggaaaacg tttttgtctg cttatccttt 1002301 ccgatgtgat aagtagcagt gatgtttttc ttgcccagct tcaaaagaat cacgcctctg 1002361 cctcccgcgc cgaatgccgg tttaaggatg caggcttttt ctttggataa aaaggagtga 1002421 atttgttcgt agcggctcac ctttatcgtt tcgggaatat agggattgat tacagagtgc 1002481 tgctgcaaat cgtgaaggac ggtccactta tcgggaagac cccgcccgat aaattccgtt 1002541 ttcggatatt ttttgagcca ctcaacgatt ggttttgctt tttgggaatg tgaatccttg 1002601 ccgtaaaaac agcgatcata aatataatct ggaatcgcca tttcagtttc gttccatgtg 1002661 ctgctggccg aatgatagac cgatgctttg acacgcaaag tgtcaggtga aatatcaaat 1002721 ggtgtaaacc ggatgaaacg tatgccgaat tcgggtgctc ttttggccag ttctgcggaa 1002781 taatccgctt catgctggcg ggataaggac ataaaaccga gtgttatcat ggtgagactc 1002841 ccccttttat tcaaaagctg ccggcgggtg tccgcagctt tacactaaat acatgtaaga 1002901 cgaacgcagc tgacggtatt ctactttaca gaatacgatt ctccaccttg ccctattcca 1002961 aaagaacaag ctgattttct aagaacagga atttgtctcc tcgtttgcta agtgattgca 1003021 tgagcctcta taatacgtat aggtacataa tctatatgaa aaaagctgaa gcacagatgg 1003081 aggaagatga ataggaatgg gtattgcagg aacctttatt tttatgatcg tgatcggcgc 1003141 tgccattgga gcggtgacca atcatttagc aattcaaatg ctgtttaggc cgtataaagc 1003201 gtactatttg tttgggaaac gagttccttt tacgcccggg ctgattccaa gacggcgaga 1003261 tgaacttgca aaacaaatgg gactgatggt agtcaatcat ctcttaaccc ctgaaggcat 1003321 taaaaagcgg ctcgtctctg atgcagccaa aacgcaggct cttcgagtgg gggaacagct 1003381 gattcaaaag ctgtcacttt ctgaagtgac agtaaaagaa gcgcttgaaa aagccgggat 1003441 gaagcgcccc gaaaaagctg ctgatgcatg gatcagcagc tggaccgatg ataagctgca 1003501 tgagcttttc cgccaatacg gggaccaatc gttaaaagag ctggtgccta tagaggtgca 1003561 ggaaaagctt gaggaaaaaa ttccgatgat ttcaggatat atattgtcac ggagtgtccg 1003621 ttattttgaa agtgatgaag gaaaaatccg tcttggcaat atgattgatg actttttaaa 1003681 agagcgcggc atgcttggaa gcatggtgca attgtttctt ggcaattcaa gccttgcgga 1003741 tcgcgtgctg ccggagctgc tgaaattctt gcgcaatgag gaaacaaata aattgctttc 1003801 tgatctctta aaaaacgaat ggggcaagct gagggagtat acgtttaatg aagcagatga 1003861 aaaatggaat gcaaaggcgc tcattttcag tttgaaacga agagtgctgc aagcattttc 1003921 gactgcccct ttcttcaaca atacgattgg cacgcttacc gtccgctatg aatctgagct 1003981 gacccagcaa atgctgccgg cactattaga caaattgctt gaaggtattt cgtccaacct 1004041 tgaaagtgtc ttaaaacggt tgcgtcttga ggaaatcgtc aaggagcagg tggatcagtt 1004101 cccggtggag cgtcttgaag aaatggtgct gtccatttca aaaaaagaat ttaaaatgat 1004161 tacctatttg gggggccttc tcggcggaat tataggcgcg attcaagcat tgtttgtcat 1004221 ccttttttaa gaagaaatgg tttttgatta atgaaaggag ctccatagtc tgttatagtg 1004281 gagtggtatg tcaaacggca atgatgaaag gagctattta caatggctgt taatttttat 1004341 gatgtagcgt atgatctgga aaatgcatta cgcgggagcg aagaattcac ccgtttaaaa 1004401 aacctttacg acgaagttaa cgcagatgaa tcagcgaagc gcatgttcga aaacttccgt 1004461 gatgtacagc ttagactcca gcaaaaacaa atggcaggag aagagattac acaagaagaa 1004521 gtgacgcagg ctcaaaaaac agttgcgctt gtacagcagc acgaaaaaat ttctcagctg 1004581 atggaagcgg agcagcgcat gagcatgctg attggtgaat tgaacaaaat cattatgaag 1004641 cctttagaag agctttacgg cagtgttgaa ggctaataag caaaatccct tcttggataa 1004701 gaagggattt tttattcact cagcaaactt ggaaatccaa tgaatctttt acctctccat 1004761 tgatgatgac tgataatgta tgaattcctt tgtaatgctt tctggtggtt aaatccttaa 1004821 aggattggat tcttgtgtat gacttcgttt cgttttttcg tatatttgtt tctgttattt 1004881 taaatacttt ctgatgacgc tggcctcttg cttttacaaa atcaattgcg tactcaattc 1004941 ttactttttg atccctgtct gaatgaatat agaaagaaaa ttcaaggctt tcgccaataa 1005001 ctatacgttt gggctggcat gttaaatcat gtagttgtat cgaatcagca ttttcataac 1005061 caaaaagcgc taaggcctgt ttatcaccct tttttaataa ggtccgatag gcgtgtttga 1005121 taatccagtc tgtatgggga tgtgttccgt accattgatc tgcgactttt ctcagtaaat 1005181 gaggatgcgt ttttgatata tcattaaggt tgttggccac gctttttctt acatataaag 1005241 actcgtcctg catcagcttc tcaaggatcg gcaatacggg ggaagggtcc gatttcaaag 1005301 ccggtatcga ttttccccat ggcaggcggg gcctgctgcc ttcgctcgca agtcttctca 1005361 cgtgttcatt tttatgctca gaccatgcaa gcaattgtgc aatcatcttt tcttgatcta 1005421 acagcaaaaa aggccttaca gcaaattctg aggtcgaata ttgcgtaaag gattccaatg 1005481 cctttattga ttcttcccaa tgcgctaacc cgtactgttc cacataatct ggaaataaaa 1005541 ttccgctgag tcctttaaaa tgaggggctg tatcccgtaa aattgtgagc gcttcaacgt 1005601 attgttttgg caaagtttcg tataaagaaa ctgtcacgcg gcgcatccgc tcttttaaag 1005661 tgagttcagg ccagtcctcc agccgtaatg tatccaagaa tctgtttttg ttaaaatcag 1005721 gataggatga ccttacatga tggatcaact gagatatcag ttcttcatta tatatttctt 1005781 ttaaatcagc catataaaca ccgctttttc gtttattatt tatattgtat gggaatgtac 1005841 gttctggatc aagtgtatag tcctaaaaat taacaactga tcctaccacg gatatacaaa 1005901 agttggttac tttttttagt taaaaaaacc cttgtcatcg gaaaggaaaa ctgagataat 1005961 aacattgaaa gcgcctacac ttacctattt caaatggata cggtcgcata tcatgccgtt 1006021 atatagaggg gataagcaac agagagtaag tgttcggagc gcatcattgg tcaaacaagg 1006081 ggttcctgat acatgatttt tcgtaaatcg aaataacgat attagggaga atggctgctt 1006141 cgatcgtatc ctatcaacaa gccatacata aagtctgctg agccaggctt tttttgcttt 1006201 aagaaaaggt tgttctaaac acagagacag ggtcatatcc tatacacaag tacagtcatc 1006261 aaggaggggg acatctctgt gtcaaaacaa ttgcttgcct taaatataga tggagcgctg 1006321 cttcggtcga acgggaagat tcatcaggca acgaaagacg cgattgaata tgtaaagaaa 1006381 aaagggattt acgtcacact tgtgaccaac cgtcattttc gctcagcaca gaaaatagcg 1006441 aaatcgctaa agcttgatgc caagctgatc acccatagcg gggcatatat cgctgagaaa 1006501 attgacgccc cgttttttga aaaaagaatt tctgatgatc atacctttaa cattgttcaa 1006561 gtgctggaga gctatcaatg caatattcgg cttcttcacg aaaagtattc catcggaaac 1006621 aagaaaaagg tgaattcgaa tttattaggg aaagcactca ttcatccgtc tgacccgatc 1006681 ttttatccag tccagttcgt tgaatcatta agcgatctcc tcatggatga gccggtgagt 1006741 gcacccgtca tcgaggtgta cacggagcac gacattcagc atgacattac agaaacgatt 1006801 acaaaagcct tccctgcggt ggacgtgatt cgcgtaaacg atgagaaact gaatatcgtc 1006861 ccgaagggtg tctcgaagga agcgggtttg gccctcgtcg cttcagagct gggcctgagt 1006921 atggatgatg tcgtggccat tgggcatcag tatgacgatc tgccgatgat cgaacttgcc 1006981 ggtcttgggg tagcgatggg gaatgccgtt ccggaaatta agagaaaggc agattgggtt 1007041 acaaggtcca atgacgagca aggtgtcgct tatatgatga aggaatattt ccgaatgcag 1007101 cagcgaaaag gatttcttga taagttccac atgaaacgtg tgtaaaaaag ccgctcgcgc 1007161 cctgacaggt gcggcggctt ttttgccgga ttgattttag cagtttattt ctgtacacta 1007221 aagaaagttt tgaatctgat aaattaggtg atgaagttgc aaattaaaat agaaggcata 1007281 catgatgacc gcctgcatcg gcctctgcaa aatattgcaa atttgtttta tgaagagtgc 1007341 gagcttgcgt atggcggaga ggagcccgca gattttgtca tttctttagc gttgtcacaa 1007401 acggatgagc atgtgacggt ttctggagaa gtgaagggta ctggcataaa ggaacagcat 1007461 acaaaattct tttctccaga catgactgaa aaagaagctt ttaagcaagt gaaaaacaca 1007521 atttcttatg tgtatctcaa tcttcttcag gcgcatacgg gcattacgca gaagtgggga 1007581 atcctcacag gaatccggcc cacaaagctg cttcataaaa aactgcaaag cggaatgtcc 1007641 aaggagcaag cgcatgctga gttgaaaaaa gactatttaa ttcatgatga aaaaatcatg 1007701 ctaatgcagg aaattgttga ccgtcagctg gcggcagtgc cggatttgta ccgagtaaag 1007761 gatgaagtca gcatttatat cggcattccg ttctgcccga caaaatgcgc gtattgcaca 1007821 ttccctgcgt acgctatcca aggacaggcg ggcagagtcg gctcattcct atggggactg 1007881 cattacgaaa tgcagaaaat cggtgaatgg ctgaaggagc atgatgttaa ggttacaacc 1007941 atttactttg gcggcgggac gccgacaagc attacagcgg aggagatgga tctgctgtat 1008001 gaagaaatgg tccgctcctt cccggatgtg aaaaacattc gtgagattac ggtggaggcc 1008061 ggtcgtcctg acacgattac agaagaaaaa ctcgccgttt taaacaaata tgacattgat 1008121 cggatcagca tcaatccgca atcctacgaa aacgaaacgc taaaggcgat cgggcggcac 1008181 catacggttg aagagaccat tgagaaatat catctgtcac gccagcacgg catgaataat 1008241 attaacatgg acttgattat tggtttgcct ggggaaggcg tgaaggagtt caggcacagt 1008301 ctttcagaaa cagaaaaact gatgccggaa tcccttaccg ttcatactct ttcatttaaa 1008361 cgggcgtcag aaatgacgag aaacaagcat aagtacaaag ttgccggcag ggaagaggtt 1008421 tctcaaatga tggaagacgc ggtagcctgg acgaaagagc atgggtacgt gccttattat 1008481 ttataccgcc agaaaaacat tcttggaaac cttgaaaacg tcggatactc tttgccggga 1008541 caagaaagca tctacaacat tatgattatg gaagaggtgc agacgattat tggcatcggc 1008601 tgcggcgctg ctagtaaatt tattgatcgg gatacaggga aaattacgca ttttgcgaat 1008661 ccgaaagatc cgaaatcgta caatgagcgc ttcgagcact acacggacga aaaaatcaaa 1008721 tatttagagc agatttttga aaaaacgaca aagcagcact gattacagtg ctgctttttt 1008781 tatccctgtt tttttgcggg ctgaacctca ggcttccatt taaatacctt gttcagcaag 1008841 cggtaaattc gttttgattc ctttgtgaca agcggtccca aaatcgccag aatgaggaca 1008901 tataatgcgg caaacggctt taatgtggcc gacagtccgc cggctatccc gagattcgca 1008961 acgataatcg aaaattctcc ccgcgatacg atcgtcagcc cgatattcga tgaagcctta 1009021 tgagaaagcc ctgcgcgtcg tcctgccacc attccggcga taaaatttcc cagaatggtc 1009081 aaaatcactg cacccaacgc aagccaaacc gcttcaccaa gcgaaaacgg atcgatgctg 1009141 aggccgaagc tgaaaaagaa catcgcaccg aagaagtcgc gaaacggaac aacgaggtgt 1009201 tcaatcctat cggaatgctc tgtttctgaa aagaccaaac cgagcagcag cgcgccgatt 1009261 gcttctgcta catgaatcgt ctctgaaaaa ccggcgataa aaaagagtgc tgcgaaaatg 1009321 acgataataa acacttcgtt tgagcgaatg tccaacagtt tgttcaacag cggcgggagt 1009381 tttcttgctg cgataaaaaa cagcagcata taaccgaagg cgatcaaaat ggacaagagt 1009441 gcactcccta cggatgtcgc atcacctagt ataaggccgg aaacaacgga cagatatacg 1009501 gcaaggaaaa tatcttcaaa catgatgatg ccgagaatca attcggtttc cgggttggcg 1009561 gttcttttta aatcaacgag cacttttgcg acaatcgcac ttgacgagat tgtgatgacg 1009621 cctgcgagga tgaggacttc cagaaaggaa aatccggtga taaacccgta aagcagtccg 1009681 aggctgaagt taatcaaaat ataaatcgtc ccgccgaccg cgattgattt tcctgatttg 1009741 attaacttcc cgacagagaa ttcgagtccg agatagaaga ggaggaacag tacgcccatt 1009801 cgcccgaaaa actcgatgat ttcactgctt tgaataaatg ttagatcaat aatccccatt 1009861 ttcggcgcgt gcggtccaac aagcattccc agcacaatca gaaacggaat aatcgaaaat 1009921 ttaattttat tggcgatcac actggcgatt gccacaagca caagtgcagt tccgacttca 1009981 aatacaagat ggtccatcgg ggctcacacg ccctctccag aaagaaaatc gtgaatcagt 1010041 ttcttcagat gctttctctc acctgagagg acaagggtgt cattttcttc aataatcgaa 1010101 tccgctccgg gatttaggag cttttcctgg ttgtgtttga taatcgcaat aacagtgaca 1010161 tcgtaattct ggcgaacatc aagctcaccg agtgtgcgtc cgatcgattt ggcgcctttt 1010221 tcgaccttaa accattcaat aataagatcg ctgaaggcca tttcgatgga ctccagagct 1010281 tgcggtttat agaccatgcc cccgagaata gctgcaattt gccttgcttc agaatcatcc 1010341 aatgaaatat ttgaaagaag ctcatccggg tcccggtcat taaaccggta aatttccctt 1010401 cttccgtcat catgaatgat aatcgtcatt ttttcgtggc ttcttgtttc gatttcaaac 1010461 tttttgccga tgcccggcag atcgttttct ttaatattca atgaaaatcc ctccgaatgt 1010521 agtgttggca gtatggggtg agttacaaat aaaacttgag caaattatat tcggaggtaa 1010581 ttagactggt atttgacagg gacggccaaa gccttttcca gcctgtttat cagcggttcg 1010641 tcaagtggtt tgacagagag ctgcctgaca gactgcgcca gcgggctgta ctctttgatc 1010701 agctcagccg ggtgcatgct gcccggcgat ggcgtttttg ccgattgtgt ttcctgcgga 1010761 tatgaagaca taggcacata gctgtcagtg cttgcttcaa actgggaagg cagaaccacg 1010821 tccgaagggg gaaagtacac cataaataaa cttaacagaa aactgatcag caatttatcc 1010881 atgttccttt cctcccttct catcaagata tcccttcttt ttcactatat aaaactttat 1010941 gtttccattc aaacaatatg catttttcag tatctattga ccttgaaaaa taaaaaggtt 1011001 tatttgggga tggcggggaa tgtataggag aaagaaaaaa gtaagcgcat acatggaggt 1011061 gcttttaatg gagtttgttc aatatgcatg taatggggcc gttgcagaga ttatcctgaa 1011121 tcggcctgat gcccatcacg ccctgaatga acagatgctg tctgaattga aggaggcagt 1011181 cgaaatggcg gctgcaagcg aggcgctcat cgttctcctg agaggaagcg ggaaaggctt 1011241 ttcggccggc ggtgatatca ggatgatgac gtcagagcat gaccctgacc aatttaaacg 1011301 gctgatggat acgattgagg ctgtcaccct gaatttatat cagatgaaga aagtgacaat 1011361 tgcagccatt catggtgctg ctgcgggact gggcctgagt ttggcgcttt gtgcggacat 1011421 tgtgctcgct gaaaaaaacg ccgttctcgc gatgaatttt atcggcattg ggcttgttcc 1011481 ggacggcgga ggacattatt tgctgaagaa aagaatcggt gaagcaaaag cgaaaaaact 1011541 gatttggagc ggaaaaaaac tatctgcctc ggaagctgcc gatatggggc ttcttgatgg 1011601 gacatttgcc ggagaccctg ccgaaggcgc aagacccatt atcgaaaccc tgttggcctc 1011661 ccctcttttg gcgatgatcg aaacgaaagg tatttttcaa agcctccaaa ttgaagaact 1011721 gaaaaaagtg ctatcccttg agcgcagcgc ccaagagaga atgagaagga ccaaggatca 1011781 ccaagaagga atccgtgcct ttttagaaaa acgggagccg aagtttcaag cgtaacagat 1011841 cagccggaaa gctgatcatc tgtgaaacaa aatcagcttt ccggctgcat tgactaaacg 1011901 atgagtatga ctatgaagct ctttttcttt taagagggct tcaccatgcg tttttgccgc 1011961 ttcttcatgt tctgcctcga attgctcgtt taccagcgtg ttccccgaag gatcaaatac 1012021 ggtaaggaaa taatcagcca tcaggtttct cctccatttt aaggtttatc agtctttctt 1012081 catttatatt ctaaaaagga aatcaaaatc ctttattatg ctttatccaa aattagtata 1012141 taatgggtca gggaaggagg agattcagtg cttacaattg atcacgtaac gaagacattt 1012201 ggagattata aagccgttga cggattggac ttagatattc cggaacagca aatgttcggt 1012261 ctattaggcg caaacggagc gggaaaaaca acaacgtttc gcatgatcct aggattatta 1012321 agcattacgg agggctcaat cagctggaag ggccgtcctg tgaattatca tatcagcaac 1012381 aaaatcggtt atttgccgga agagcggggc ctttatccga aaatgaaggt aagggatcag 1012441 ctcgtctatc ttgccagatt aaaagggatg gagaagcgag aggctgtaaa agagctcggg 1012501 acatggcttg aacgcttcaa tattacagat tacgagaata agaaggtgga agagctttcg 1012561 aaggggaatc agcagaaaat ccaattcatt tcggcagttt tgcataagcc ggagctcctg 1012621 attcttgatg aaccattcag cggcttggac cctgtcaatg ttgagctgct aaaagaggcc 1012681 gtgatctcgc tgaaaaacag cggtgtttct attttatttt caagccatcg gatggaacat 1012741 gtggaggagc tttgtgagaa cctttgcata ttgcagaaag gaaaaccggt tgtacaaggc 1012801 aagctgaagg agatcaagcg ttctttcggt aaaaagaatg ttaccattca ctccgatgac 1012861 gatctgcgct ttttgcagtc ccatgaaggc attcttcaat ggaaggaaac ggcagacggc 1012921 gtcaagctgc agattgccaa tgaagacatt tctcaagaga tttttgcgat gctccaagga 1012981 aaagggttta tcagaaagtt tgagcttgaa gagccgtcac tgcatgatat ttttatagaa 1013041 aaggtggggg ccgtctatga ataaattttg gatcatgctt tctcatacat acaaaaataa 1013101 gattatggca aaatccttta ttatttcgac tgtcatcacg gtgctgcttg ttttagttgt 1013161 aacgaatctg gagtcgatca tttctttgtt tcaaggtgac gatgcgaaag aaaaaatcgc 1013221 cgttgttgat gaaacaaacg aattatatcc ggttttttct aagcagctga aagcggtgga 1013281 tacagacggc gatcttgatg tgaagctgtc gaagcaatcg gaggatgagg tcacaaagca 1013341 agtcaaagat gaatcactcg atggcatgct catcatcaaa cgagatgaaa aagggaccat 1013401 ttcaggaaca tataaagcgt taacgatttc tgatgaaagc acgtatcaaa cactgcagca 1013461 ggcgctgacg caaaccaaaa cagctgtcgg aacagcggag ctcggcgtgt cgcaggaaac 1013521 gattagcagc ctttatgcgc ctgttactgt ggggcagaag gcgctgaaag aaggggcaaa 1013581 gtctgaggaa gagcttggcc agacggtagg gcttgtttac attatgctgt tcgtcattta 1013641 tttctcggtg attatgtatg ccagcatgat agcgatggag gtcgcaaccg aaaaatcttc 1013701 gcgagttatg gaaatcctga tctcaagtat gccgccgatc cagcaaatgt ttgcaaagct 1013761 gcttggtatc gggcttgtcg ggatcacaca gcttgctatt attataggag ccggctctct 1013821 gtcgcttaag ctgaaccaaa agagcgaaac ggcttcatct gtcggcggat tccttaattt 1013881 gaccgacgta tctgcaacca ctgtcatcta tgctgtcatt ttctttttgc tcggatactt 1013941 tttgtacgcg acacttgccg cgtttctcgg cagtgtcgtc agcagaatag aggacgtgca 1014001 gcaaacgatc acgccgatga cgcttttggt tgtcgccggt tttatgatcg cgatgttcgg 1014061 tttgaatgcg cctgacgcag gatttattac ggtaacttcg tttattccgt tctttacgcc 1014121 aatgattatg ttcctgcgcg tcggcatgct tgatattccg ttctggcagg cggctgtcgg 1014181 aatcggaatc acactgctca ccattgtcat actggccgtt atcggcgcca gaatttataa 1014241 aggcggtgta ttaatttacg gcaattcaag cgcgttcaaa gcgatcaaac aagcgctacg 1014301 tttagcgaaa aactgattgg aaaacagcct ggggattctc aggctgtttc tttattgaca 1014361 gaacgtgcat tcgcaagaat tcggtgctaa aataagggta cttcatcctg gaaaggagca 1014421 gaatgttgac tgatctaacc tttattcatg cggcagatct tcatcttgac agcccgtttt 1014481 acgggatatc gcatctgccg gagccgattt ttgcccggat taaagaaagc acgtttgcaa 1014541 gcgtgagaca tatgatagac gccgcagtga gagagcacgt tgatttcatt ttgcttgcgg 1014601 gagatctgtt tgatgaagcc aatcgaagct taaaggctca gctctttttg aaaaaacagt 1014661 ttgaaagact cagagagtgc ggaatttcgg tatacgtcat ctttgggaat cacgatcatc 1014721 ttggcgggga gtggacgccg attgaatggc ctgagaatgt ccatattttt tcgtccgctg 1014781 ttccagaaga aaaatcgttt tttaaagaag gcaggcgcat agcaagcatt tacggcttca 1014841 gctatcaagc cagagcattg atggaaaacc aagccgcccg ctatcggaga tcaactgacg 1014901 caccgtttca tatcggcatg ctccacggca cgctgtcagg atctgaagga cacgatccgt 1014961 attgcccgtt tacacatgac gacctcgtga aaagcgggat ggattattgg gcgcttggcc 1015021 atatacataa acgccaggtt ctatctgccg agcatccggc agtcatttac ccgggaaaca 1015081 cgcaagcacg ccatataaag gagacgggag ataaaggcta ttatctcgtt catgtgacaa 1015141 acggagatat atcttatgaa tttcagagag cgcatgatgt cctgtgggaa aaagcggcgg 1015201 ttgatgtgac ggaggcaaag aatatgacag ccctcttcca aatggtggag gacacgtttt 1015261 cgaagctgcg gaaaaagggg agccctgttt gtgtaaggct tgttttacaa gggacggcgc 1015321 cggaatggct gctggaggcg ccaaaaggca ccttggatga gtttcttgaa gctcttcagg 1015381 aacaagaagc ggaagaggaa cgtttcgttt ggcctcttag attggacgat gagacagaaa 1015441 acgaagcaaa cctaacaaac cttgatcctt tttttggcgg tttatttgaa gacattgatc 1015501 gcagcgatct gtcagacgtg ctggaagggc ttgagcggca tccagtgtat agaaggcacg 1015561 cggaccggtt tagccaagag gaggtaaagg aaataaaaga gcaggcacag ataatattga 1015621 aaagacagct taaggtgctt gatacatgag gcggtgacag ctttgcgaat tatatcttta 1015681 catatctacc aatacggaaa attttccaat cggacctttg acttttccgc ctctcctgtc 1015741 caagtcatct acggattaaa tgaggcagga aaaacgacga tgatgtcatt cattgaaagc 1015801 atgctgttcg gttttccgaa aacgaaaaag tatgaaccga aaacaggcgg tgtctacggc 1015861 ggtgttcttg aagctgaaca tcctgagtat ggggtgctga agatcgaacg gacgaaaggg 1015921 actgccgaaa aactaagcgt gtacacagaa aagggcgaag taaagcaggg agatgtttta 1015981 aagcagctgt tccagggcac agacaggtcg ttgtacaaag ccatatattc gttcgacgta 1016041 ttcgggctgc aggaaattca cgcctttaat cgggacaaga taggggaatt tttgctcttt 1016101 tccagcttgt ttggtgctga agccgtatca aagcttgatt caaggctgac gaaggaaagc 1016161 gaaaggctct ataaaccaaa tgggcgaaac cctcaattga atcaggagct ggaaacgctt 1016221 aagcagctgg cagttaagct aaaacaggct gaagcagagg aagcgggcta tcatcagctt 1016281 ctcgaggaaa aacgaacgct tgaagcccgc cttgcagccg cggaaaccga attgaaagag 1016341 acggcgggac atatccgaat gattgaggga gcgattgagc gaaagccgct gctaaatgaa 1016401 aaagcgacac tcgaacaggt gattgcagaa tttccggaac acgcaggaca atttcctgct 1016461 gacggactgc atcagctgga aaaatatgaa tcccatcttc acccgaaatc agcacagctt 1016521 gaggcgcttc gggtgaagat ggcggagttg gacaaacaga ggcaaaagct tatccccgat 1016581 aaagaactat tggcgaaaga aacgctgata caagagcttt cggcagcgtt tcatatgtac 1016641 caatcctggg gagaacagct ggcagccatt caggcacagc tgcgccagac gtctgcgcag 1016701 acagcggcag ggctggaaca gctcaataaa acggatgaaa atgagctcct gaatatgaac 1016761 acctcatatg attatgaatg gcagcttcag caagcggtgc agcaatatgt acaggcaaga 1016821 gacagaaaac ggcagcttga cgagacgttt gaacttgccc ggcaagagct ggaagacgcg 1016881 gaaaaggccg ttcgtgccgc ttcgtccgcg attcttgaaa acagccaaag aaaagataaa 1016941 gaagcagctc ttagagcata tgatgaaaca caggggcagc accaagagca agcgaagctc 1017001 agagaacagc taacgttttt tgaaagacag caggctaaac agaaaaagac tgtcattgca 1017061 gctggtatgt tgttcatcgt tctcttttct ctgctgcagc aatggattcc cgccataagt 1017121 ttcggcgctg cacttattgt gtattggctt gtttcaggaa agtcgtcttc tcgaaacagc 1017181 cgagagacaa gacagcccat gacggatatt tcaccagcag aagctgaaat gcttagagaa 1017241 gcgttatggg aggatgaccg caataagcag caccttctca cacagcgtgc agcgctccag 1017301 caaaaagagg cggcgtatga aagggtcatc cagcagtttg aacagtggga agccgaaatg 1017361 gcgccgtcct ttacacaggt tgagcgtttt atgaatgagc tcggatttaa ggaagatcca 1017421 tcatttttgc ttgatgcata cagcttaatg aaggatgtta aaaaagaagt gaagaaaaag 1017481 catgagctga ccatagaagc aggcaggctg aaaaagcacc ggagaacatt cgaagaacgc 1017541 gtcagtatgc ttcttcccgt gaatcagagt caggatatct ccatttcgga cgcccttcac 1017601 acattgcgga aaaacattga acgtgaaaaa gaaattgaga agcaaaaaaa ggaaattgaa 1017661 acagatattc attatacaaa ggaacagatg cttgaacttg agcaagaaat acagtatttc 1017721 cacgcacaga ttgaacagtt atttgccgcg gctgctgcaa aagacagaga tgcgtttttt 1017781 gccatagccg ccatcagcag gcaattgaag gatacggaga acaagcttca tcacgtaaac 1017841 gcacagcttc aaggcgggta cccggaggaa cttgaactgg cggattccaa tacgctttct 1017901 gaattgaaag ataagcaatt tgttgagaat gaaagaaaag agcggctgac tgaggagatc 1017961 gagcagctcc gcagccaaat cgcactgctc tcagtcaaac aggaacaatt agaggcttcg 1018021 ggaatggtct cagacctcaa gcttcaaacc gaaatgcaaa aagaacgtgt gaaagaaacg 1018081 gctaaaaaat gggcctccat acaaatggtc aaacaggtga tcagaaacaa attggagcgg 1018141 cataaaaaaa tcgagcttcc gcgccttctg gagacggcag gagaattttt ccgtcctctg 1018201 actgacggaa actaccaaac catttatttt tccgaaacgg atgattcgat catggttatg 1018261 catcgcgatg gcactgtcta tcatgcggaa gagctgtcac aagggacgtg tgaacagctg 1018321 tatacagcga tccgctttgc tttggccgtt acgcgccagg gtgagtcaaa gcttccgttc 1018381 cagcttgacg acagttttgt tcattttgat caggaaaggc tgaaacgtgt attacatgtt 1018441 ctgtatgatt tatctgaagg cggtaggcag attttgtatt ttacatgcca tgagcacgta 1018501 aaagatgcat ttcatagcag ccaaatcatc catttggtgt cataaaagag gttctatagc 1018561 tgaaaatcgg tatgtgatat actggtatta tgtaagatac ggagggagct ttaatagaat 1018621 ggctaaaggg attatgctac atgaggttgg cgaacaggtg gaccagtatc tattgattaa 1018681 atcctcgacg aaagggattg caagcaatgg aaaaccgttt ctgacgctga tgctgcaaga 1018741 ccagtcaggc gatattgaag cgaagctgtg ggatgccaag caaagtgatg aagtgaccta 1018801 tgcgccgcag acgattgtca aggtcgtcgg cgatgttcac cattatcgcg gacgcaccca 1018861 gctgaagcta agaaatatca gaccggtaag cgagcaagaa aacgtcaata ttgatgattt 1018921 tttagaaacc gcgccgattc cgaaaaatga aatgatggat accatcactc aatatatatt 1018981 tgaaatgaaa aatccgaata tccagcgaat cacaaggttt ttggttaaaa aacacgaagc 1019041 tgagtttatg gattatccgg cggctacgaa aaaccaccat gagtttgtct caggtttggc 1019101 gtatcatgtt gtctctatgc tgaacctggc gaaagcaata gcagatttat atccttctct 1019161 tgatcgtgat ctgctttacg ccggtgttat cctgcatgat cttggaaaag tgaaggagct 1019221 gtccggccct gtttccactt catatacggt tgaaggcaat ttgctcggcc atatttccat 1019281 catggtgaca gagctttcaa aagcggctga ggagcttcaa atcgattctg aagaggtgtt 1019341 aattcttcag catttgattt tgagtcacca cggcaaagca gaatggggca gcccgaaacc 1019401 gcctatggtg aaagaagcgg aaattcttca ctatatagac aatctggatg caaaaatgaa 1019461 tatgatggac agagcgcttg agcgcgtgaa gccgggcgag tatactgaac gtgtatttgc 1019521 actggaaaac cgttcctttt ataaaccgac atttcataaa taacttaaaa aggactgatg 1019581 ctgacatatt cagctcagtc ctttttgatg cgtctttccc gcacataact cgtctcattc 1019641 ccgcatatgg ttaagaataa agaatctatg caaaggggga ggagcccgtg ttattttttc 1019701 cgtggtgggt gtatctttgt attgtaggca tcattttcag cgcatataaa cttgtggcgg 1019761 cagccaaaga ggaagaaaaa gtagaccagg cttttattga aaaagaagga cagatttata 1019821 tggagaggat ggaaaaggag cgagaacgcc gcagttctca gcagcatgaa gaagaaaatc 1019881 aaaaccattc catcgcataa aaaaagctgt gcggctcaat gagccgcaca gcttttttta 1019941 ttatttagaa ttgcttgaag atgaagaagt gctgttgctt gttgaagatg tattaaatgt 1020001 gtctttcaga tctttatctt ttacttcgat gtcagccttc ttcatgactt tttgaacagc 1020061 ttcctgaaca gctgcgttgt catttaattt ttgttcaagc acttcagatt tcagttcttt 1020121 tttcatatca tcatatttgc cgcgttcttc tgtcttttta atgatatggt agccgtattg 1020181 cgttttgaca ggatcactga cttcacctgt ttttaatttg aatgcagctt tgctgaatgt 1020241 ttcgtccatt tggccttctt ttgcgaacca gccaagatcc ccgccttttg aagcagagct 1020301 gtctgttgag tattctttcg caaggtcttc aaacttctcg ccttttttca gctttttctc 1020361 tacttcttca gctgtctttt tatcagcaac aaggatgtgg cttgcacgga ttttgccttt 1020421 taagccttcc cagtactctt tgatatcggc gtctgttact ttgatgttat ctttagccgc 1020481 tttttgtgtc agcaattcat attttacttg ttctttcagg taatctttgc catattgctt 1020541 ttcgagggca gtatattgat cgccaagctg cgttttgtat tctttcagct tgttgtcaat 1020601 ttctttatcc gaaactttat acttcttgtc caatactttt tcttgcacta gctgtgtcag 1020661 tacgcttgcg ccagctgttt tcttcatgtt tgtgtaaagc tcgccttttg tgacatcgcc 1020721 tgcgtctgtt tttgcgataa cttctttgtc gccgctgctg caagcactga gagcgaggat 1020781 gcttgtagca gtgatagctg ctattgcgat tttcttcatt gttttcaaac actcctaatc 1020841 attccaaatt aaattaccta tgcgtatcat aacatattgt ggctttctgt aaaaagattt 1020901 taaataaagg gcattcgtct agtcaaactt ttgctgatga catacttata tattgatcaa 1020961 gaaaaggagg tatgtaacat gagcggagga tactctaacg gattcgcgtt gctcgtagta 1021021 ctgttcattt tgcttatcat cgtaggtgca gcttacatct actaagcagc ccgaggatcg 1021081 cttgcaacat aagcgatcct ttattttcac tagcgcctaa tcgtttcaaa catgaattgc 1021141 ataacatgta attggtaaat aaagcttatt acaggaggtg ctatttaaga tgggtgaagt 1021201 atttgcaggc ggattcgctt tattggttgt gttatttatt ttattgatta tcatcggcgc 1021261 ttcttggctg tactaatcaa cataaaaaag catagctgct taatcagcag ctatgctttc 1021321 tttcgtattt acactgtaaa ggagatctcc acaaacgaag agatcagtaa aattaatata 1021381 gatacattaa taaatcggaa taccttatct tgccgctctt caggaatctc tctgacaagg 1021441 cataatgtat tggtgagcct gtttatgaaa tataaaataa acacggcagc cacgataaaa 1021501 tagaataaaa tgatgggaga ttccccctct ctctgaactg tcccatatta cattaccaaa 1021561 tatttattaa aaaagataga atgcaaattg aaaaatcgcc accagcacca gggtttgact 1021621 acttttcaac aagaatatcc aagccgtcag cttcctgatc aataaaagcg gttttcggtg 1021681 cttttatcag cttgagagcc agcaggaaat caggcagaca gtagccggcg tgaatgcccg 1021741 agatcatgca aaaataatga gcgtgattcg gaaatgccag tgctgcgtaa aacaataccg 1021801 gtgtaatcag caagaacggg ctgacgagtg aaatcagcat tgttgttttt ggtatacgtt 1021861 tccatgtgcg catgcgcaat atgtaaaact ttttttctat ttttcttttt ttgcagatga 1021921 ttggcaggac atggatgact ttatgtacaa ataaaataac gacgagcaaa ccgccgaata 1021981 aagatacata ttcatcgctt aagcttgtgc caggccgcag cagctcaaaa gctaaaaagg 1022041 tagatataaa aaccaaaatc ataaaacata cagcagttaa tattatgcga acggcgccat 1022101 aatccttcat gagatttatg gtcttccagc aattcatcaa agtcatcctt ccatacatct 1022161 tgaatagaat ctcaaaataa tttactcctc ccaagagaaa aaatcaatgc ttttttaaga 1022221 aaaaatatca tccggcaggt atttttttga aacaagcaaa caaactgcga aatatggggt 1022281 tagaactttc ttctcagtga attatcagct aaaataagat taaagataga aagaagtggt 1022341 gtggatggat tcgatggatc atcgcattga gcgattagaa tattacatac aattattagt 1022401 gaaaacagta gatatggaca ggtacccctt ctatgcgctt ctcattgata aagggctgag 1022461 caaggaagaa ggggaagcgg ttatgaggat atgcgacgaa ttgtcggaag agctggcaac 1022521 acaaaaagcg caaggatttg taacctttga taagctcctt gcgctttttg ccggacagct 1022581 gaatgaaaaa ttagatgttc atgaaacaat ttttgccctg tatgagcagg ggctttatca 1022641 agagctgatg gaagtcttta tcgacatcat gaagcatttt gattaactgt ttacaggttc 1022701 gagctcttca gccggttcat ccgccgcact gtcctttgct tttttcttca attttccgtt 1022761 tacgctttca aagtcattgt caatattggt gagtgacgtt tcgaaaattt ccataaaatc 1022821 atcgccgtag atatggcgta tcatacacat catttctgcc acttcaggaa attttccgaa 1022881 taaatgatat aaaggctgtg accctttaaa aacagcgttg cgtgtcggat caaattcctc 1022941 aagcaagctc cagaatacct cggtaccttc ctcagtcaat tggacatatg tgttccgttt 1023001 atcattcagc cgtttggaga accttaaata tccccgttct tccagctttt ttgaaaagtt 1023061 gaatgcggtt gatacgtgca tgaccccgaa tttcgcgatt tcagaaatgg aagctccatt 1023121 caattgatac gcaatccata aaatatgatg ctcattaata ttcaggtcat acggtttgag 1023181 ccattgctgc caatccttct cgatcgattt ccaaagagcc ttgctaagct gagccatttt 1023241 ctgggtgaaa accagagctt ctttcacatc atagggcggt tccactcgat tcattacgtc 1023301 acctgcttct ctttttcttt ttctctatta tgccaataaa ataaagatta ataaagatga 1023361 aaatgtaaga attttttaat aaattcacaa accattgcga cgaaagggtt tttcggccaa 1023421 aaaaaatacg ggtccaattt tggcccgcat ttttttcttt tgaataggat attagttttg 1023481 taaggttttc tccagctgtc tgattttctc ttcgatatcg gcaatttctt tttgcagatc 1023541 ctgctggtga ggcttgatct cttcctgcca ttttttaatt gatgtttgga gctcgccgcc 1023601 cacgtcttta ataacatccg tgctttcttt tgccgctttg atcagctggt cttttaatgc 1023661 aagcccgtct gactttaagc gtttgattgt ttcttcaaaa gaatcataat tggttttcat 1023721 tttttcacgc agctgctttc ctgaggaagg tgcagtaaga agaaccgctg ctcctccgat 1023781 gatgccgcct acgaatagtc ctgttaatag agaacgtccg ctcgccatta caatcacccc 1023841 gtctttttct tcaaaatagg attcattcag catttttcat ttttgttgaa agcctgaact 1023901 tctatacata gcttgcttta ttttagcata ttttttaagt gaaaaggagg gagaaggttg 1023961 tctgtctttt tgattgtatt atcctgcatc acccttgcct tcgcttcagg cgctgtttac 1024021 tatatcaaac ttctcagcca ggctgcttct tatccgccca agagggttat ccggcagaaa 1024081 gcgcttgttt gttcaaccgg aaccgccttt acactatgtc ttatcttttt cacaaaactc 1024141 ctcgcttaaa acatgctgac atgctgcggg cgctctgttc aaaaaaacct ctcccggaag 1024201 cggaagaggt tttgtgtgac aattatttag cagcttccat aaagcttgaa cgccttaaaa 1024261 tggtttgcac aatcggataa ataatgatca ttgagattgt attcagcaca gcggccggca 1024321 gaacaacagc cgcgaacaat gcggcgaaac cgcccggtaa accgacgatc aataaagctg 1024381 acgatagaaa cacaattcct gataagatgg tcccgatcac tgtcagcaca gcggctgcac 1024441 ctgttttccg gctctttctg aacaagagaa acagggagaa gaacagaaac gctgatacgg 1024501 gtttatcaat gatgttaggg atctgtccgg ctggaaacgc ggttgtaagc gcggaaatga 1024561 ttccggtcac gatcccgatg acgagtacat tttgcacccg cgggaacagc agaatgccca 1024621 tgaacatcat gatcagcatc atatctggtt tcatgccgcc taaaaagggc ggaataatgg 1024681 aatgaagcgc tgcgccgatt gcggcaaaca gagccataat gactaactct tttgttttca 1024741 taactatgct ctcctctgct aagctttttg ccctccaata atatgctcat catttattgc 1024801 gaaggcttta cagaatgtgt tatgcaaaca gtataccaaa cggacggttt gcatagccag 1024861 actttttact cattttcctg ctggaatttc ttcatgaacg cagctaattt ttcacagtct 1024921 tcgagagaga ccgcgttata aatagaagcg cggcagcctc ccaccgaacg gtgtccgcca 1024981 aggccgatca tcttcgcatc ttttgctttc tgaacgaatg ttttcgttaa ttcgtcatcc 1025041 cgaagcgtga atgtgacatt catgcgtgag cggctgtctt ttctggcatg tcctttatag 1025101 aagccgttgc tttcatcaat acagctgtag agaacctgcg ctttttgttc attgcgctgt 1025161 tcaacagctt ccacaccgcc gttttccttg agccattcca gaacgaggct cagcatataa 1025221 atcgcaaatg tcggcggagt gttgtagagt gaatccgctt tgacatgcgt ggaatatttc 1025281 aagatttttg ggacgttcgc attttcattt tgcagccagc tttttttcat gatgactaca 1025341 gtcacgccgg aagggccgag gttcttttgg gcgcctccgt agatcacatc aaatttggac 1025401 acatcgattt ttctgcttaa aatatcgctg gacatgtcgg ctacgagcgg aattggagaa 1025461 ttcggaaact cctgccactg agtgccgaaa attgtattgt tggatgtgat atgtaaatat 1025521 gcgccgtctt ttacatccgt aaggtcaacc tctggaatat aactgtaatt gtctgtttca 1025581 cttgtagcgg tgatagacgt gttcccgaac agtttcgttt ctgccagtgc tttttcagac 1025641 caagcgccgg tcatcacaaa atgtgcggtt ttttcaggtg ttaaaaagtt catcggaagc 1025701 attgagaatt gaaggcttgc cccgccttga agaaacaaga tatcgtaatc ttccggaatg 1025761 cccatcagtt cgattaagag gcttttcgct ttttggtgca ccgcttcata ctctttgctg 1025821 cggtgggaaa gctccataac agacatgccg gattcgttaa aatcaataaa ttctttctgt 1025881 gctttttgca gaacttccag tggcagcgct gcaggacctg cgttaaaatt cgttgtacgt 1025941 tccattatga tctctccctg ttttccacgt taatgtataa aataatacaa ttatcctatc 1026001 acaaaaattc agttttttga taaaaaatta gaattatcaa aagaaattga cggatgtttg 1026061 cgaaatgttc acaaaataaa ataacctcat cttatgatga ggccaggcgt tttgcgatag 1026121 aggaagagat gttctgcaga tcctccggtt tataatcatc agcatgcgtt ttccaaaccg 1026181 ctccgaatcc atctcctttt ccgtagcgag ggataatatg catatggtag tggaacacag 1026241 attgtccagc tttttcgccg ttattgttca gcgtatttaa gccgatcggt tcaaattcat 1026301 cccggatagc gcgggcgatt tttggaacag catggaaata ttgttttgct aattcatctg 1026361 taaattcata tacattctca atatgtgttt tcggaatgac aagcgtatgg ccttttgtca 1026421 cttggctgat atcaagaaag gcaagtacat gttcatcttc atacaccttc gctgatggaa 1026481 tgtcgccggc aataatttta caaaagatac aattctctgc acaatgcatg agggttcctc 1026541 cttatgaaat tgtttagtat gtatacattc atcgtaccac agaaatgcag aaaatagaaa 1026601 acaggatgaa cggcgagcgt tcaccctgaa tgcagaggaa gagcttatat gaagaaaatg 1026661 tgttatgcct ttggtaagca cctcatttgt caataaaatg aagacttgtt taatgcctaa 1026721 cgattcctgc gataaacacc tcatttgaca atttgcttca tacatgaaga attcatcaat 1026781 tcagtgaaga gaaatggttt gagcattgga catgtttatt ttctatccaa ctgtttctaa 1026841 gacgtctttg acaaacacct catttttcag ttgatatgct tttcctctac aacttttatg 1026901 atgtccagaa ccctgtctct ttatgacagc aaattcatca tttgttaaaa gggaattgtt 1026961 tcaaatcagg ccttgttttt ggtactatga agaaaaacac tataagggga gaaactatgt 1027021 ctctgctatc ggtaaaagac ttgaccggcg gatatacaag gaatccggtt ttaaaaaacg 1027081 tatcattcac ccttgaaccg aatcaaattg tcggcttaat cgggctgaat ggtgctggta 1027141 aaagtacaac aatcagacac atcatcgggc tgatggaccc gcataaaggt tcaatcgaat 1027201 taaacggtaa aacgtttgct gaggatccgg aaggctaccg ttcacaattt acctatatac 1027261 ctgaaacacc tgttttatac gaagaattga cgctgatgga gcatcttgaa ctaacagcca 1027321 tggcatatgg actgtcaaaa gaaacgatgg agaaaaggct gcctccgcta ctaaaggaat 1027381 tccgaatgga aaagaggctg aagtggttcc cggcccattt ttctaaagga atgaagcaga 1027441 aggttatgat tatgtgcgca tttttggcag agcctgcgct ctacattatt gatgagcctt 1027501 ttctagggct tgatccgctt gccattaacg cgctgcttga acggatgaat gaagcgaaaa 1027561 aaggcggggc gagcgtgctg atgtcaacac acattttggc aacggcagaa cgctattgcg 1027621 attcgtttat tattttacat aacggcgagg tgcgggcgcg cggcacgctg tcagagctca 1027681 gagagcagtt tggaatgaag gacgcggcgc tggacgattt gtatcttgag cttacaaagg 1027741 aagacgctgg ccatgaataa tatgcttgat atttggcagt cgcggctgca ggagcatatc 1027801 aaagaaacaa gaacatacat gaaatatatg ctcaacgatc acctcgtcat tgttttgatt 1027861 ttttttctag cgggcgctgc aagctggtac agcaaatgga tacgggacat tcccgctcac 1027921 tttccgtcct tttgggtgat ggccgtgctg ttttcgctcg tattgacaag ctcttatgtg 1027981 cgaacgcttt tgaaggaggc tgaccttgtt ttcttattgc ctcttgaagc aaaaatggag 1028041 ccttacttga agcaggcgtt tgtctacagc tatgtgtctc agctgtttcc gctgattgcg 1028101 ctgagcatcg ttgcgatgcc gctttatttc gcagtcactc cgggagcttc gctcgtatcg 1028161 tatgccgcgg tctttgtcca actgttgctg ctgaaagcgt ggaatcaggt aatggaatgg 1028221 cgaacgactt tccaaaacga ccgcagcatg aaacggatgg acgtcatcat tcgctttgcg 1028281 gcgaatacac tcgttcttta ttttgttttc caatctgttt atatgtatgc gcttctcgtc 1028341 tatgtcatta tggctgttct ttatctgtat atgtcttccg cagcaaaacg gaaaacattt 1028401 aaatgggaga gccatattga gtccgaattg agacgaaagc agcgtttcta tcggattgcc 1028461 aacctgttta ctgatgtgcc gcatttgcga aagcaagcca aacgcagagc ttatctcgac 1028521 tttttgctgc ggcttgtgcc gtttgaacag cgcaaaacat ttgcctatat gttcacccgc 1028581 gcctttttgc gttcgagcga ttatttgggc attcttgtca gattaacgat cgttttcgcg 1028641 ctgatcatta tgtatgtctc agccagcccg ctgattgccg cggttttgac tgtgtttgcc 1028701 attttcatta cgggcattca gcttctgccg ctcttcggtc actttgacca tctggcgctt 1028761 caagagctgt accctgtgca aaaagaaaca aagctgaaaa gctatttctc tctattaaaa 1028821 actgcactta gtattcaagc gctgctgatg tctgttgcat ctgcctatgc agccggcttg 1028881 accggttttc tgtacgcgct gatcggttct gccgttctga tttttgttgt tttgcctgct 1028941 tatatgacga ccaggctgaa aaagcacgga aagctgtgaa ctgaaaagag gtaatcaaat 1029001 gacagataat cagctgctga tgcaggaagc tttggaatgg aaaatgcatt ttttgcgaaa 1029061 ggattccatg tttgaacgct tttcgaagcg tgtccagacg aaggtgaatg aacggattcc 1029121 tgaaaaaatc catacggtcg tcaccgagag tgtgaaaaaa atggtagaag cgacaatggc 1029181 cggctctaat atcatcacct ataaaaagga tacaagtgca ctgtcgctca gtgaaaaaaa 1029241 cgaattggcg aaaaaaacga ttgtttctta tcaaaaagtg gcagctgctg agggagtcgg 1029301 caccggagcg ggcggcattt ttttaagcat tgctgatttt ccgctgctgc tttcaattaa 1029361 gatgaagtgt ttatttacct tgtcttccat ttacggcttt gatgtcaagg atgcacaaga 1029421 aaggatattt ttgctgctcg tgtttcagct tgcgttttcg agtgatgatg gccgtaagtc 1029481 gcttttttct gtcatcgaaa attgggagac ggagaaaaag agcatcgact ggagagtgtt 1029541 ccagcaggaa tatcgcgatt atatcgacgt cgtgaagctt tttcagcttt tgccgggcgt 1029601 aggagcggca gtcggcggaa ttgccaatta taagctgctt gctcagcttg gagaaacggc 1029661 aagacatgtt tttcatctga ggatattaaa ggaaacagcc ggagaataaa cactccggct 1029721 gtttttttat agctgatgat aggtgatcgc agcgccggca aggaccttgg ccgctgtcag 1029781 catggctttt tcgttgatat caaatttcgg atggtggtgg gaatagactc gctctggctg 1029841 ttcgggagcg gcgcctgtaa agaaaaaagt gcccttcacg ttttgtaagt aataagcaaa 1029901 atcctcgccg cccatttgtg gttcaccgtc aatgacctgc tgaacgccct cggtattctt 1029961 tgcggtgctc accaagtggt tcgtttctgc aggatggttc acaaccgctg gataaccctg 1030021 ttcataggtg tactcatagg acgcgccgtg catgctgcat attcctttta caaccgcttc 1030081 aatttctttc tccagaatgt cccggacatt ttcatcaaaa gaacgcgctg tgccgatgag 1030141 tactgcttgg tctgcgatga cattaaacgg attgtcggcg atgaaggagc ctgtcgaaat 1030201 gacggcggat tgaatcggat tgactttgcg gctgacaatg tgctgcaaag aggaaacgat 1030261 ttgcgaaccg attaggacgg cgtctttagt atcatgcgga tgagcgccgt ggccgccctt 1030321 tccgaagact ttaatcgtaa atcggtctgc cgccgccatt acggcgccgg ggcggcagag 1030381 aatagttccg agcggctcag ttgcccaaag atgagtgccg aatatcacat ccgtgttttc 1030441 gagacatccg tcatcaatca ttggctttgc gcctccagga taatattctt ctgcatgctg 1030501 gtggatcatc acaaatgttc ccttcagttc atgtctgttt tggtgaagga ccttggccac 1030561 tgcgagaaga gctgcggtgt ggccgtcgtg gccgcatgca tgcatgacac caggcacttt 1030621 ggaggcgtaa gggacatctt tttcatcttg aatggggaga gcgtcaaagt cggccctcaa 1030681 agcgactgta gggccgggtt cgcttccttc tatatttgct aaaacccctc taccgccaac 1030741 gtttgtgcgg attgggactc ctaacgattc ataataggaa gcaataaatg cggcggtttt 1030801 ttcttcttga aatgagagct caggatacat atgaaaatgg cgcctgatct caaccatttc 1030861 ttcaaaacag ccgtcgagct gtttgtttat ctctttctgc agtgtggata tggacaaagc 1030921 cgcttccccc ttttctatgc ttttccatga ttgtatagaa aaagtctgaa tatttcaact 1030981 catgctgttt taaagcatca tcacagctgc gagggttgtc accaaaaggc caatcgcgac 1031041 gggaatgaag ttttttctgg caagctcaaa aggatcaact ttgcaaatgg ccgcggcggg 1031101 aatcaaagcc catgggacca gtgttcctcc gcccacccag atggcagaga tttgtccgag 1031161 cgcggtcaga atagcgggat cggcatggag agcggacgaa aagagctttg cgatggagcc 1031221 ggcgagagaa atgccagaaa atcctgagcc gtcaaggcct gttatggctc cagcggcagt 1031281 taatgcagtg gcggcaagct cctttgacat aggcatcata tgggataaag caatgccaag 1031341 atcgttgaca atgccgtggg aacctttagg gagtgaagtg cccagtatgc tttcatagcc 1031401 tgagtcgcca agataaaaga aagcggcaat cgggatgacg gggccgaaaa ccttaaaacc 1031461 gaacttaaat ccgtcaataa aatagccggt gattttttca agccctttat gcttatacac 1031521 gaaaaaatga acggtaaaga ggatacaaat tgcagacccg ccaattaacg cggttgcatc 1031581 atttccttgt aggttaaaca agagcatgca ggcgatatct gcaagaaagg caagcggaat 1031641 caaaaaagcc agtatggacc gcaggcgttt tggcaagtac agcgagttgt cttgttcgcc 1031701 ggaaagaacg ggggaaaaag aagtgggatg ctcctgtttt ttgcgttcgc gctgaatcat 1031761 gataaaggca gcagttgttg ttgtcacacc cataatcagc acaagcggaa tactggccga 1031821 gacgacatca ccgactggaa tgcctgctgc atccgcagtc agctttggcg ccgcctgaat 1031881 gacaaagtct cctgacaggg caaaaccgtg tccgaataag ttcatggcca tggccgcggc 1031941 aagaggcgtc aaaccggcac gtgcggctgc ggggagcagg acggcgccga tcaaagcgac 1032001 acccggagaa ggccagaaga atagagaaat ggcgaacatc aggcctccaa tcagccaata 1032061 ggcagtcaca ggccctctca caaggcttgc aaagggagaa atcatcgctt catttatccc 1032121 tgtttttgtt aacaaatcac tcattgaaac gataaagcaa atgatgaaaa tcgtgggcag 1032181 cagttcgccg gccgcataga taaagctgtg gaataaactg ctgacagaag ctgaaagtga 1032241 atggctggcc catagcgata tgataaaaat gccgaataga gaaataaatg tcgtgtcttt 1032301 tctcagcagc ataaatagga taattgcacc gataaaaaac acatacagaa catggacagg 1032361 caaaatcccg acttccatca tcgatcactc cttccgctta cagattattc ataggcgggc 1032421 ggaaggtgcc gggacagagg ggagggttat gatggaagat gaacattgat ctgtttcagc 1032481 tgctcaatca gatgatgcct taatcctcta ttcgcttttt gcagatgttt tgggaagcat 1032541 tcaggagaaa aaatgacgca cccttcagca agccagtttt ttctataggc gatgatgctt 1032601 tccgatggct ctatatgagt tatcctcgtg ctgcatctcg tactcatcaa atccgaactg 1032661 aaaaccgcag cacgggcaga tttcatgaga atgattgcct tcatgatcat atggcggttc 1032721 agccaatcct taaacccgca gactgggcaa gtatgcttca ttttgctttc ctcccaataa 1032781 aataagctgc cggacatgcc ggcagctatt cgacagcgaa atatgtggtg acataggaag 1032841 gccgggagaa gatcgacgtt gtgtcaattc cggcagatgt atcgcgtttt ttgtgggctt 1032901 ctttgtaaga accggactgc tgccagtctt gaaaggcgct ttccgtttcc cacaaggtca 1032961 gaatgacata ggtgtcactg tcaagcggac ggagcactcg aattgcttca aagccaggct 1033021 cgttttcgac ttttcccgct ctgtttttaa atctgttttc aaacagcgga cgcccttcct 1033081 gagtaacggc aatattgttc aatactgcaa aaccgggatg tttgatctct ccgacttggt 1033141 caatgacttc ataagcgtgt ggtgcctgga aaacggtatc tccgtttgtt tcatgaatta 1033201 aaatggcgtt ttcctgcccc tgcatcaaaa ggatattttc tgagggatgc ttctgtacga 1033261 tcgtttttaa aaaatcggct gtcccatatg taatataaac cttcatatca gccacctcct 1033321 gcttgctagt atatcaaaac aatggtataa gtttctattg gcgagtgctt cgaacataat 1033381 tccaaacaat ttttcccata ctacctttag aaaggcgagg tgagttcatg tttaagataa 1033441 agaaaaagaa actttttata cctatcatta ttttagtgtt aactgctttt ctcgctttaa 1033501 taggatatat ttcaattatt tttctcggcc attatgtcat agatgaaaaa aagcttattc 1033561 ttcatgcttc ttcaaaaatt gttgatcaaa acggagatga ggttgcaagc ctgtatacag 1033621 aaaatcgcga gccggtctcg atcaatgaga ttcctaagca ggtcagagaa gcgtttatcg 1033681 ctgttgagga taaaaggttc tatgagcatc acggcattga tgcaaaatcc gtcggaaggg 1033741 cagtgtaccg cgatatatta gcaggcggaa aggtggaagg cggaagcacg atcacccagc 1033801 agcttgccaa aaatattttt ctgacacatg acaaaacatt tctaagaaaa acaaaagaag 1033861 tgatcattgc gattaatctt gaacgggatt acagcaagga caagctgctt gaaatgtatt 1033921 taaaccagct ttacttcgga cacggggttt acggcataca agcggcgtcc cactattatt 1033981 ttaataaaga agtaaaagat ttgactgtat ctgaaggcgc tgttttggcc gctattccga 1034041 aggcgccttc tacgtactct ccaattttgc accctgataa aaataaggag cggcgtgata 1034101 caattctagg tatgatgaat gaccaaggct atatcagtgc gaaagaggct gtcaccgcac 1034161 agggccggac gcttggactg catgtgaaga aacagtcgga aacaccttgg tttgacagct 1034221 acattgacct tgtgatcaaa gaggcggaag acaagtattc catttccgga gagcagcttc 1034281 ttcaaggcgg atacacgatc aaggtgccgc tcgattcgaa gctgcagaag acggcttacc 1034341 aggtgatgaa agagggaagc tattatcccg gaacagatca gaatgccgag ggaagcgcgg 1034401 tctttattaa taacaagaca ggcggtgtag aagcggccat cggcggaagg gattacacat 1034461 ccaaaggata taaccgtgtc acagctgtcc gccagccggg ttccacattt aagccgcttg 1034521 ctgtatacgg accggcgatg caggaaaaga aatttaagcc atattctcta ttgaaggatg 1034581 agttgcagtc ctacggagat tatacgccga aaaactacga cagccggtat gagggcgaag 1034641 tcactatgtc tgacgccatt acgtacagca aaaacgcgcc ggctgtctgg acgctgaatg 1034701 agatcggcgt cgaaacaggg aaatcttatt tgaaagcaaa cggcattgat atccctgatg 1034761 aaggccttgc tcttgctcta ggcggcttgg aaaaaggcgt ttcaccgctc cagcttgccg 1034821 gcgcgtttca tacatttgcc gcgaatggaa cgtatactga acccttcttt atctcgagca 1034881 taatagatga agacggagaa acaatagccg atcataaaga agaaggaaag cgggtattca 1034941 gcaagcagac gtcttggaat atgacgagaa tgctgcagca ggtagtcaaa aagggaacgg 1035001 ccacgtccgg cacctatcac ggcgacctgg cgggaaaaac aggttcaaca tcttatacag 1035061 gcgtctccgg cgcgacaaag gacgcctggt ttgcaggcta tacgccgaaa ataaccgggg 1035121 cagtctggat gggctatgac aaaacggatc aaaaccatta tttgaaagcc gggagctcat 1035181 acccgacgcg gctgtttaag gatattttga cacaggcagg agaaaccggt catgtgttca 1035241 caaagcctaa aaacgttaaa gaactggaaa gcccgattga gctgaagccg gtcaaaacac 1035301 tcacagccga ttacacattt aaagcagcgg ggctctttac tattgaatta aagtgggacg 1035361 ctcaagagga tgatcgggcc gtatacagaa tttatgtaaa caaggacggc gaggagacgc 1035421 ttcttgattc ggttgaaggg aagggaagct atgaaattcc ttatgccaac ttattttcgg 1035481 gcgcgtctta taaaattgtg ccttataata cacagacaaa aagagaaggg gaaggaaccg 1035541 attacgttca gccaaaattg ttttcctctt aatggaattc ggcgattttt tgaactttga 1035601 gctacatttc tataccattt gcctaaaaca aggtatagtg taataagtca agaaatacga 1035661 acgtatggtt gccgtatgaa aggtggaaat cagatgagta aacgagaaac gtttaacgag 1035721 acgtttttaa aagctgcgcg gggagaaaaa gcggatcaca cgcctgtgtg gtatatgagg 1035781 caagcagggc gctcacagcc ggaataccgc aagctgaagg aaaagtacgg attgtttgag 1035841 atcacacatc agcccgaact ttgtgcgtat gtcacaagac tgccggttga gcaatacgga 1035901 gtcgatgctg caatccttta taaagatatc atgacgccgc tgccgtcaat cggtgtggat 1035961 gttgaaatca aaaacgggat cggtcctgtg attgatcagc caatccggtc tctggcggac 1036021 attgaaaaac tcggccagat tgatccggaa caggacgtgc cgtacgtgct tgagacgatt 1036081 aaactgcttg tcaatgagca gctgaacgtc ccgctcatcg gtttctcagg tgcgcctttt 1036141 acgcttgcaa gctatatgat cgaaggcggc ccgtcgaaaa actacaataa aacaaaagcc 1036201 ttcatgtaca gcatgccaga tgcatggaat ctgctgatgt ccaagcttgc cgacatgatc 1036261 atcgtgtacg tgaaagcgca gattgaggca ggcgcaaaag cgattcaaat ctttgattcg 1036321 tgggtcggcg cattgaatca ggcagattac agaacataca tcaaacccgt gatgaaccgg 1036381 atcttttcag agctcgcaaa ggagaatgtg ccgctgatca tgtttggcgt tggcgcaagc 1036441 catcttgcag gtgattggca tgaccttcct ctcgatgttg tcgggcttga ctggagactc 1036501 ggcattgatg aagccagatc aaaaggaatt actaaaacag tgcagggcaa cctggacccg 1036561 tccattttgc ttgcgccatg ggaagtcatt gagcagaaaa cgaaggaaat acttgatcag 1036621 ggtatggagt cagacggctt cattttcaat cttggccatg gggtatttcc tgatgtcagt 1036681 cccgaggttt tgaaaaaact gacagcattt gtccatgaat attcacaaaa caaaaaaatg 1036741 ggtcaatatt cctaagcata tcttttggta tcttaatgat atcctgtcaa aatgtttgta 1036801 tcagatcatt aaagagggtg taaacagtga gtagaaagaa aatggggctt ctcgtgatgg 1036861 cgtacggcac gccttataag gaagaagata ttgaacgtta ttatacacat atcagaagag 1036921 gcagaaagcc tgaacctgaa atgcttcaag atttgaaaga cagatacgaa gcgattggcg 1036981 gcatttcacc gcttgcccaa atcacagaac agcaggcgca taatctggaa cagcacttga 1037041 atgaaattca ggatgagatt acgtttaaag cgtatatcgg actgaagcat atcgagccgt 1037101 ttattgaaga cgccgtagca gagatgcata aggatggcat tacagaagca gtcagcatcg 1037161 tgctggcgcc gcatttctcc acgttcagcg ttcagtccta caacaaacgc gccaaagaag 1037221 aggctgaaaa actcggcggc ttaacgatta cgtcagttga aagctggtac gatgaaccga 1037281 agttcgtgac atattgggtt gaccgagtga aggaaacata tgcgtcaatg cctgaggatg 1037341 aaagagaaaa cgcaatgctc atcgtatccg cacacagcct gccggaaaaa atcaaagaat 1037401 ttggagaccc gtacccggac cagcttcatg aatcggcgaa attaattgct gaaggcgcag 1037461 gcgtttccga atatgctgtc ggctggcaaa gtgaagggaa cacgcctgat ccttggctcg 1037521 gacccgatgt tcaggattta acacgtgatt tattcgaaca aaaaggctat caagcatttg 1037581 tatatgttcc tgttgggttt gtcgcggatc acttagaagt gctttatgat aatgattatg 1037641 aatgcaaagt ggttactgac gatatcggcg caagctatta ccggccggaa atgccaaatg 1037701 ccaagcctga atttattgat gctttggcaa cagtcgtatt aaaaaaatta ggacgttaaa 1037761 gaaggcgatg aacatgagtg acggcaaaaa acatgtagtc atcatcggcg gcggcattac 1037821 cggtttagcc gccgccttct atatggaaaa agaaatcaaa gaaaagaatc tgccgcttga 1037881 gctgacactt gttgaggcaa gtccgagagt cggcgggaaa atccagactg tcaagaaaga 1037941 cggctatatc atcgaaagag ggccagactc atttctggaa cgaaagaaaa gcgccccgca 1038001 gcttgttaaa gacttaggtc ttgagcattt gcttgtcaac aatgcgaccg ggcaatccta 1038061 tgtgcttgta aaccgcaccc tgcatccaat gccgaagggc gctgtaatgg ggataccgac 1038121 aaaaattgcg ccgtttgttt ctacgggtct gttttccttg tccgggaagg cgagagctgc 1038181 tatggatttc atcctgcctg caagcaaaac aaaggatgat cagtcattgg gagaattctt 1038241 ccgcagacgt gtcggagatg aagtggtcga gaacttaatc gagccgctac tatcagggat 1038301 ctacgcaggc gacattgaca agctcagcct gatgtcgaca tttccgcaat tttatcagac 1038361 ggaacaaaag catagaagcc tgattctcgg catgaaaaaa acaaggcctc aaggctcagg 1038421 ccagcagctg acggcaaaaa aacaagggca gttccaaact ctgtcaaccg gtttgcagac 1038481 ccttgtagaa gagatcgaaa agcagttaaa gctgacgaag gtgtataaag gcacaaaagt 1038541 gaccaaactt agccatagcg gctcttgcta ttcgctcgaa ctggataacg gcgtcacact 1038601 tgatgctgat tcagtaattg tgactgctcc gcataaagcg gctgcgggaa tgctttctga 1038661 gcttcctgcc atttctcatt tgaaaaatat gcactccaca tccgtggcaa acgtcgcttt 1038721 aggtttccct gaaggctccg tccaaatgga gcatgagggc acgggttttg tcatttcaag 1038781 aaacagtgac tttgcgatca cagcctgtac gtggacgaat aaaaaatggc cgcacgcagc 1038841 gccggaaggc aaaacgctgc ttcgggcata tgtcggaaaa gccggagacg aatccattgt 1038901 cgatctatca gataatgaca ttatcaacat tgtgttagaa gacttaaaga aagtcatgaa 1038961 cataaacggc gagccggaaa tgacatgtgt aacccgatgg catgaaagca tgccgcagta 1039021 ccatgtcggc cataagcagc gtatcaagga gctgcgtgaa gcacttgcat ctgcgtatcc 1039081 gggtgtttat atgacaggcg cttctttcga aggtgtcggc attcccgact gcattgatca 1039141 aggaaaagct gccgtgtctg acgcgcttac ctatttattc agctaaaacc tccgctttat 1039201 cgcggaggtt tttttgatgt gcaatggcaa tattgtgtaa aaaatgattg aattgaacag 1039261 caggttatga tacatttgca tatgtactta atgactaaaa tgttcaaacg gtcagtttcg 1039321 aggtgaatac aatgtcaata gatcgaaaaa agctcatttt ggaggcggct acaaagtctt 1039381 tcacgcagtt cgggtataaa gcgacgacaa tggatcttgt cgcaaaactt gcgaacgtgg 1039441 ggaagggaac catttatact tttttcaaaa acaaagaaga gctgtttgac gagattttca 1039501 ctactttatt aaaggaaatg aagcaaaaag cggatgaagc gatggagccg agccttccgt 1039561 tccatgaaaa tgtgcacaga gcgctgtttg ccattctgga gttcaggaaa acacatcagc 1039621 tgacgattaa aattttccaa gagaatgccg agattggtac aatggcagtt caggaagtga 1039681 tccagaaaat ggagcgatcc atcctgtctt atatcaaaag caagattgaa gacgggatca 1039741 aaagcggcgc aatcaagccg tgcgaccctg agctgacagc ctttgtgatg ctgaagcttt 1039801 atatcgcgct catttttgac tgggaaaaac aacacccccc gcttgataaa gagacaattg 1039861 cgggactgct tgaattgtat gttgtcaaag gattgtcagc gaactagata atcctttctc 1039921 tttgcaagaa aatgaccatt ttttatgatg agtcagtttt agaatggagg catcaggatg 1039981 aacacaatac gaagtcagtg gaaagacatc gtaacaagta aaaaattatt gattcccatc 1040041 atcgccattt tgtttgtccc gcttatttac agcggcgtat tcttaaaggc ttattgggac 1040101 ccgtacggca cagttgacca gctgcctgtc gttgtcgtca accaagacaa gggagcaacg 1040161 tatgaaggag aaaaacttca aatcggtgat gatctggtca aagaattaaa ggataataac 1040221 aactttgatt ggcatttttc caatgatctc gaccaatcgt taaaggactt attgaatcaa 1040281 aaatattatt tagttgtcga gattcctgag gatttttcta agaatgccag cactgtatta 1040341 gacaaaaatc cgaaaaaatt ggatctgaaa taccatacaa atgcaggttc taactatgta 1040401 ggggcaacga tcggcgaaaa agcgattgat aaactgaaag cctctgtttc aaaagaagtg 1040461 accgagcaat atacgaaagt tatttttgat aactttaaag atatcgcaaa aggtttgagc 1040521 gacgcgagca gcggcgcgaa aaaaattgat gacggcacaa aggatgcgaa aaacggaagc 1040581 gcccagctga aagaaaatct ggcgaagctg aaggaaagca ccgctaccat cagtgacaaa 1040641 acagcgcagc ttgcagatgg agcggctcag gtgacgagcg gcatccaatc acttgacagc 1040701 tcgctcggta aattccagga cagcagcaac cagatttatg ataaatctag tcagcttgca 1040761 gcaggatcag gcgagctgac aagcaagatg aatgaacttc ttgccggact tcaaaatgtg 1040821 cagaagggta cgcctaatct tactaacggg ttggatcagc tcaacagtaa agtccaagaa 1040881 ggttctgaga aagcggcaaa agcggaaaag atcattaatg cgctcgattt aacgaagctt 1040941 gaaactgctg taaacaatct ggaaaagtca gaaactgcga tgaaggaatt caaaaaacag 1041001 ctgactgact ttgaaaacag tttgaaaaac cgtgatcagg catttaaaaa tgtcatcaat 1041061 tcgagtgact tcttaacagc ggagcaaaaa agccagctga ttaattctgt tgagaaaaag 1041121 cttccgcaag ttgatgcgcc tgattttgat caaatattaa gccagctacc tacagctgat 1041181 cagctgcctg acatcgcaac gataaaaagc tctcttgaag acgtgaaagc gcaggtggcg 1041241 caggtgaaag ccatgccgga agctacatct aagctttata acggcgcaaa aacaatccaa 1041301 gatgcgattg acagattaac tgagggagct gataagatat acaacggttc tcagaagctg 1041361 acagatggcc aaactaaact gacagcgggc atcggtgaat ataataagca gttcgcaaaa 1041421 gcaaaagcgg gctcagagca attggtgaca ggaagcagcc aagtatccgg cggattgttt 1041481 aagctgttag acgggtctaa acaggtccaa agcggatcat caaaacttgc agacggatct 1041541 gcatcacttg atacaggttt aggcaagcta ttggacggca caggagagct gtctagtaag 1041601 ctgaaggatg cggctgacca aacaggagat atcgatgctg atgatcaaac atacggcatg 1041661 tttgcggatc cggttaaaac caaagatgat gccattcatt ccgttcctaa ctatggaaca 1041721 gggctgacac cttatatcct gtcaatgggc ttgtatgtcg gcggcatcat gctgacggtt 1041781 gtcttcccgc tgaaggaagc gtcaggacgt ccgagaaacg gttttgagtg gttcttcagc 1041841 aaattcaatg tcatgatgct tgtaggaatc attcaatcat tgattgtggc gacggttctt 1041901 ctattgggaa ttggtcttga ggtagagagc acgtggagat tttacgtgtt tacgatcatt 1041961 acgagtctcg ctttcctggc gataattcaa tttttggcta caacgatggg caacccgggg 1042021 cgatttatcg cagtcattat tttagtgctg cagctgggag cgagcggagg aaccttcccg 1042081 ctggaattgc ttccgaattt ctatcaggtc atccacggcg cattgccgat gacctacagc 1042141 attaacggat tcagagcagt catttcaaac ggtgactttg gctacatgtg gcagatggcc 1042201 ggcgtcttaa tcggcattgc cctcgtcatg attgcactaa gcattactta ctttacaatg 1042261 ttaagccgga aggaagaaac atcagaagaa cagccggctt cataaagaaa aagaacttgt 1042321 ttccttggaa acaagttctt tttttgttac atcccccatt taataagcaa tcctgtatag 1042381 gttaatccgc cgccaaaccc gaaaagcaaa acgatttgat cttttttcag cttcccggct 1042441 ttcactgcga gatcgagcgc caaaacaatt gaaaccgaag acgtgtttcc gtagtgctca 1042501 acactagtga gcgttttttc aatcgggaac ggtgtttttt cacaaattga ctcgatcatg 1042561 cgcaagttgg cgctgtgagg aacaaaccaa tcgagatcat cggagctgag tcctgcttta 1042621 tgtaaaagcc gttcaaattc gccagggacg gttcttgcgg cccatttata tacctcgcgt 1042681 ccgttttgca ccatttttcc ggaaccgaca agctgcacac cgtttatttc atttcgcagt 1042741 ccggcacgat acaaaatatc gccgccgttc ccgcttgttc cttgtacaga cgcaagaaat 1042801 cccggcgtct cttcatctcg ttctactaac agcgcacccg cggcatcgcc gaacagtacg 1042861 catgtcgttc gatcggtata atcggttacc tttgataacg tctctccggc gatgacgaga 1042921 attttttgat gaaggccaga tgtgatcaat ccatttgcca aatggaggcc gtatgtcagc 1042981 ccggcgcatg tcgcattaat atccagcgcg ccggtgcttt cccagccgaa atattcctgt 1043041 acgcggcatg ccgtactcgg aaaggcgtaa tcggatgtgg ttgtggcaac gaggatcata 1043101 tcgacatcat caagcgttcc tttataacgg ctcttgagat tcttcaccgc ttctatgcat 1043161 aaatcagagg taaattgatg ttcatccgca atccggcgtt ctctcattcc tgtgcgctga 1043221 acgatccatt catcagaggt atcaacgatc ttttctaaat ctgcattggt taaacgtctg 1043281 ctcggcgcat aggtgccgat agctgtaatt tttgcttttg acatatgaat cactccttat 1043341 ggtcagatta taacactaga tattagtatc tggtactaaa aagaaggttt ttttacaaaa 1043401 aaagagaagt gtagatagga atctatgaaa aagaaaaagg aggctgaaaa atggtcagtc 1043461 aagaagcagt agtctttttg gcattatccg gggctattgc gtttctgttg ccaatcgggc 1043521 tgattgtatg gtttaagcga aagtatggtg cctcgcttaa agtgtttttt attggcgctc 1043581 tcacgttttt tgtcttcgct cagctgctgg aaggcggcgt tcatgtttat gtactgcaag 1043641 tgaatgaaat gacgaaagaa gcgatgcagc atccattatg gtatggcatt tacggctgct 1043701 tgatggccgg catttttgag gagtgcggaa ggtatttgat gatgcgattt tttatgaagc 1043761 gccatcatac ttgggcagat ggtctggctt tcggggcagg ccatggcggg cttgaagcca 1043821 tcctgattac aggcttgtcc tctatctcac ttattgtata cgcatttgca atcaatagcg 1043881 ggacgtttga acagcttttg gtcaatggcg acgtcaaaca ggcgcttttg ccgatacagg 1043941 agcagctgct gcatactcct tcgtatgaat ggatgctggg cggaatagaa agaatcagtg 1044001 ccattgccgt ccagattggt ctgtctctgc ttgttttgta cgcggttaaa aaccgccggc 1044061 cgctgttttt gctgtattct attcttttac atgcactgtt taatgtcccg gcggttttat 1044121 atcaaagagg aatcatagag catgctgcag ctgttgaaat cattgttgct cttatagcgg 1044181 ctttatcagt ttattggatt gtaaaagcaa aaagggtgtt tcaataaaag gtccaagcag 1044241 cagcaatgcc cgcttggaaa aatgtgaatg gaaatattca ttaagcatgg gtcatcagaa 1044301 tatttctgat tcagtcttta gcaatgacag caagaatgtc tgtgtttttt acaagagaaa 1044361 caatggtgtt tctttttctt cttctcgcaa gggtcatggc attctttctt tttcttgcaa 1044421 tggtcgtgga aatctttatc gaaccactcg tcaaagaacc aaaaatcatc gaaccaatcg 1044481 tgacaacgac atttctgttc atgtgaatga cgacagcaca tagaaatccc tcctcttccc 1044541 atgctctcta cagcatatga gagattgata ggaaaagatt ggacgggtcc ctcgggaaaa 1044601 gagtatattt taagtagaaa ataaaaggag gaatgcccta tgacgtccgt acgtaaaacg 1044661 atggagctca ttaaagaact tgtatcgatc ccaagcccga caggaaatac atatgaggtg 1044721 atcaattata ttgaaagcct tttaaaagaa tggaaggtag aaacggttcg gaaccacaag 1044781 ggcggcttaa ttgcaacgct tccaggacgc gacacatccc ggcatcgcat gctgacagcg 1044841 cacgttgaca ccctcggcgc tatggtgaag gaaattaaag cggacggccg gctgaaaatc 1044901 gacttaatcg gcgggttccg ctacaactcg attgaggggg agtattgcca aattgaaacc 1044961 gcctcgggaa aaatgtacac aggcacaatc ttaatgcatc aaacgtctgt gcacgtatac 1045021 aaagacgcgg gaaaggctga gcggaatcaa gagaatatgg agatccgcct agatgaacct 1045081 gttcactgcc ggaaagatac ggaggagctt ggcattggcg tcggagactt tgtgtcgttt 1045141 gatccacgtg tcgagatcac atcaagcgga tttattaaat cgcgccattt ggatgacaaa 1045201 gcaagcgtcg ccttattgct ccgcttaatt catgaaattc aaacagaaga cattgagctg 1045261 ccgtatacaa cccattttct tatttccaat aatgaagaaa tcggttacgg cgggaattcg 1045321 aatattcctc ctgaaacagt tgaatatttg gcggttgata tgggcgctat cggtgacggg 1045381 caggcgacgg atgaatattc agtatcaatc tgtgtgaagg atgcgagcgg gccgtatcat 1045441 tatcagctca gaaagcattt agttcaatta gccgagaagc atcatattga ctataagctt 1045501 gatatatatc cgtactacgg gtctgatgcg tcagcagcga tcaaatccgg gcatgatatt 1045561 gtgcatggcc tcatagggcc gggaattgac gcttcccatg catttgaacg cacccataaa 1045621 tcatctcttc gccataccgc taagcttctg tattactatg tacagtcacc aatggtataa 1045681 gggggaggac caatgaagat ttataagctg aaaagcacat tcggttggga aggtgatgac 1045741 gggttgggag aacagctgat tcagcagatc cttgccggag aaaaaagcgc cacgtgcgcg 1045801 ccgaaatcat tgtattcaaa agatgaattg agggacgttt atcaaacagc gggtcagctt 1045861 gttaccgttt atgataaaca tgacaatcca agatgcaata taaaagtaac agatgtcttt 1045921 gaaaccacct ttggtgcgcc tgatatgagg ttagtcaaag gagagggcaa tggagaccga 1045981 attgaggagt ttcaagagga tcatcggatg gcatgggcgg aactgatcaa aagcggtgaa 1046041 ctggagctga atgaggatac tgttttgatt acagagttgt ttgtgcttgt taaagattaa 1046101 aaaagcctgc ggggcaagaa ccccgcaggc ttttcattaa ccagaaatgg ttgcgttttg 1046161 ttctgttttc gattgggaca taacagtttc tgctttcgca ggattaaaca tgccttccca 1046221 tttagacatc acaacggcag caagcgcgtt accagtcagg ttgacaactg tacgtgccat 1046281 atccatgatg cggtctacgc cggcaataaa ggcaagtcct tcagccggaa cgccgatggt 1046341 gccaagcgtt gcaagcaaga caacaaaaga agtaccaggt acggcagcca tccctttgga 1046401 tgtcaccatt aagacgagca caagcgtaat ttggtgccaa atcgtcaaat caatgccata 1046461 tacctgtgct aaaaagagtg cggcaataga ttgatagaga acggaaccgt ctaagttaaa 1046521 cgtgtaaccg atcggaatga caaatgaaac aatgcctttt ggacatccga ttttctccat 1046581 tttttccatg atacgcggaa gaaccgtttc agagctggac gtactgaacg ccagtaagat 1046641 ttcgtccttc atgtaagcaa ggaacttgaa gatgctgatg ccggcaattt ttgcgacaat 1046701 cccgaaaata acaattaaga agaaagcaag cgcgacataa accaatccga cgagctttcc 1046761 gagagagata agagaaccga gtccgaattt agacacagtc actccgataa gagcgaaaac 1046821 gccgaatggc gccactttca tcacaaggtt tacaacgtgg aacatggcat gggatacacc 1046881 ttcaaaaaag gctaatacag gcttgcctct ttcaccgatc gcggaaatac ccaatgcaaa 1046941 tagtactgta aagcagatga tggctagaag atccccttcg accaatgact ggaagaagtt 1047001 tgtcggcaca atatggagga acgtttccgc cactgattta ttactttgtt ctttttcagt 1047061 ttcaacatat tgactgatgt ccgatttttg agcttcgtgt atattaactc ctgtacccgg 1047121 atggaagatg tttgcaaggg ctagtccgag aataatggca aaagtcgtga tgatctcgaa 1047181 gtacagaatc gttctgaagc ctaatttacc gacttgcttt ccatttcctg caccggctac 1047241 accgatgatt aagctggaga caacaatagg aatcactatc attttgatta agcgtaaaaa 1047301 gagatccccg attggctgca ggtaagtagg caatgctggg ttgccatacc aaatgacgcc 1047361 aacaatgaca cctagaataa gtccaacgaa tatttgtgtg gctaatccaa acttaattct 1047421 tttcatagat tacctcccaa aaaacaaagt atcaacatat atcatgaata gacatatatt 1047481 taatctcact attagatcaa attataatag ataagaaatc aattcgtcta tagtaaatta 1047541 tatttcgaaa ataaagaata ttcaatgaca ttatgataat caccagaatt atctaaaaac 1047601 aggtgagctt tgacctaacc tgactattat ttcaaaatta agagatatgt gaaaaaataa 1047661 gaaaatccca cgcgtaaggc gcgggatttt cgctcattac aaatcgttta cttttataca 1047721 gtcattgcag atattaccat aacactcatg ctgctcttct atcttttttc cgcattccgc 1047781 acactttttc gaaggcaggt ttctaaaaaa ttctgtgatt ttccccagca taaccaatcc 1047841 ctctttcccc tttgtagtga tttcattgta atataacaga ttacaaaaat caataactgt 1047901 tttgatacaa tgtttaaaac atgctttttt caagaaaaat gggtatattg aaggaggacc 1047961 aatttttttg aaaagatagg aggacattat gaaagttaca gttatcggat gctatggcgg 1048021 ttttccggcc gcaaatgaag cgacgtcagg ctatttgttt cagtcaggtg attactctct 1048081 gcttgttgat tgcggcagtg ccgtattgtc taagctgttc ggatatgtgc cggcggaaaa 1048141 gctggatgcg gtcgttctgt ctcattatca ccatgaccat atcgctgata tcggaccgct 1048201 gcaatttgcc aagcaagtcg gttcgtttct cggcaaagga gagcatacgc ttccgattta 1048261 cggacatgat gctgatatag aacagtttca aaagcttaca tataaaacac atacaaaagg 1048321 gatcgcctat cagccggatc agccgctgac tgccggtccg tttacgatca cctttttaaa 1048381 aacgattcac ccggtgacgt gctatgccat gcggattact gacggcagcc acactgtcgt 1048441 ttatactgct gattccagct atcaggattc atttataccg ttttcgaaag atgctgattt 1048501 attgatctca gaatgcaatt tttatgccga tcaagacgga acaagtgcag gccatatgaa 1048561 cagcctggaa gctgggcgca ttgcaaaaga agccggagcg ggagaactgc tgctgacaca 1048621 tttgccgcat tttggcgtgc atgacaacct tcgcaaagaa gcgaaaaccg tttttaacgg 1048681 agaagtgaat attgcgaaat caggttttgt gtgggaagga taaaggagga gcaccatgtt 1048741 atttatagac aatcaaaata tcaatgatcc gcggatcaat cttgctatcg aggagtactg 1048801 tgtaaagcat ttagaccctg aacagcaata tttgctcttt tatgtgaatc aaccgtctat 1048861 tatcattggg aaaaaccaaa atacaataga agaaatcaat acaaaatatg ttgaggaaaa 1048921 cgggattatc gtcgtccgcc gtttatcagg cgggggcgct gtgtaccatg atctggggaa 1048981 cttgaacttc agctttatta ccaaggatga cggggacagc tttcataact ttaaaaaatt 1049041 cactgagcca gtgattcagg cgttacatca gcttggggtt gaagccgaat taagcggccg 1049101 gaacgacatt gtagtagatg gccggaaaat atccggaaac gctcagtttg caacgaaagg 1049161 ccgtattttc agccacggca ccctcatgtt tgattcagcc attgatcatg ttgtatcagc 1049221 attaaaggtg aaaaaggata aaattgaatc aaaaggcatc aaatcgatca gaagccgagt 1049281 ggcaaacatc agtgagtttc tcgatgataa aatgaccacc gaagaattcc gcagccattt 1049341 gcttcgccat atttttaaca caaacgacgt tggaaacgtg ccggagtata agctgacgga 1049401 aaaagattgg gagaccattc atcaaatttc gaaagagcgc tatcagaatt gggattggaa 1049461 ctacggccgc tcaccaaaat ttaaccttaa tcattcgaag cgttatccgg ttggatcgat 1049521 cgatttgcac ctggaagtca agaaaggcaa aatcgaggac tgcaaaatct tcggagattt 1049581 cttcggtgtc ggtgatgtat ctgaaattga aaacctgctg gtcggaaaac aatacgaacg 1049641 cagcgtcatc gctgatgtgc tcgaaggtgt gaatctcaag cattactttg ggaacattac 1049701 gaaagaggat ttccttgatc tgatttacta aggcaaaaca catcgtttga aagagcggtt 1049761 gtgtttttga aataatggag gcaggaggga ttcacatgaa agtgttttta atcggagcga 1049821 acggacaaat cgggcaaaga ctcgtctctt tattccaaga taatcctgat cattccatca 1049881 gagcgatggt cagaaaagaa gaacagaaag cgtctcttga agctgccggt gcagaagctg 1049941 tgcttgcgaa tctggagggc agcccggaag aaatcgccgc tgcggcaaaa ggttgtgacg 1050001 cgatcatttt cacagccggt tccggcggca gcacaggcta tgataaaacg ctgctggtgg 1050061 atcttgatgg agcggcaaaa gccattgaag ctgcggccat tgccggaatc aaacggttta 1050121 ttatggtcag cgccctgcaa gcccataacc gtgaaaattg gaatgaggca ctcaagcctt 1050181 attatgtggc caagcattat gctgataaaa ttctggaagc gagcggttta acctatacga 1050241 ttatccgtcc gggaggcctt cgcaatgagc ctggaacggg aactgtttca gcagcgaagg 1050301 atctggagcg gggatttatt tcccgtgatg acgttgcaaa aacggtcatt gcctctttag 1050361 atgagaagaa tacggaaaat cgggcctttg atctgacaga aggagatacg ccgattgccg 1050421 aagcattgaa gaaactatga cagtactgac actcagggct ttttgctctt gagtgttttt 1050481 ttctgtttct ctataatgga gaagaaagct tggcttcaat aatgaatgac tattcattca 1050541 cttaaggggt gggagaatga atcttgtttc aaaattggaa gaaacagcat ctgagaagcc 1050601 cgacagcatc gcatgcaggt ttaaagatca catgatgacg tatcaagagc tgaatgaata 1050661 tattcagcga tttgcggacg gccttcagga agccggtatg gagaaagggg accatttagc 1050721 tttgctgctt ggcaattcgc ctgattttat catcgcgttt tttggcgctt taaaagctgg 1050781 gatcgtagtt gttcccatca atccgttgta cacgccgaca gaaattggtt atatgctgac 1050841 aaatggcgat gtaaaggcaa tcgtgggcgt tagccagctt ttgccgcttt atgagagcat 1050901 gcatgaatcg ctgccaaagg ttgagctcgt cattttatgc cagacggggg aggccgagcc 1050961 ggaagctgcg gacccagagg tcaggatgaa aatgacaacg tttgcaaaaa tattgcggcc 1051021 gacatctgcc gctaaacaaa accaagaacc tgtacctgat gataccgcgg ttattttata 1051081 tacgtcagga acgactggaa aaccgaaagg cgcgatgctg acacatcaga atttgtacag 1051141 caatgccaac gatgtcgcag gctatttggg aatggatgag agggacaatg tggtctgcgc 1051201 tcttcccatg tttcacgtgt tttgtttaac cgtctgtatg aatgcaccgc tgatgagcgg 1051261 cgcaactgta ttgattgagc ctcaattcag tccggcatct gtttttaagc ttgttaagca 1051321 gcagcaggcg accatttttg ccggtgtgcc tacaatgtat aactacttgt ttcagcatga 1051381 aaacggaaag aaagatgatt tttcttcgat ccggctgtgc atttcgggag gcgcgtccat 1051441 gccagtcgcg ttgctgacgg cgtttgaaga aaaattcggt gttaccattt tggaaggcta 1051501 cgggctctcg gaagcatcac ccgtcacgtg ctttaacccg tttgacaggg gcagaaagcc 1051561 gggctccatc gggacaagta tcttacatgt cgaaaacaag gtcgtagatc cgctcggacg 1051621 cgagctgccc gctcaccagg tcggcgaatt gatcgtgaaa ggccccaatg tgatgaaggg 1051681 ctattataaa atgccgatgg aaacagagca tgcattaaaa gacgggtggc tttatacggg 1051741 ggacttggca agacgggatg aggacggcta tttttacatt gttgaccgga aaaaagacat 1051801 gatcattgta ggaggataca atgtgtatcc gcgggaggtg gaggaggtgc tgtacagcca 1051861 tccggacgtc aaggaggcgg ttgtcatcgg cgtgccggac ccccaaagcg gggaagcggt 1051921 aaagggatat gtggtgccga aacgctctgg ggtaacagag gaggacatca tgcagcactg 1051981 cgaaaagcat ctggcaaaat acaagcggcc tgccgccatt acgtttcttg acgatattcc 1052041 gaaaaatgcg acggggaaaa tgctcagacg ggcactgaga gatattttgc cccaataaaa 1052101 tgaaaaagcg aagcggttag cttcgctttt tcattttcaa tcctttgctt cttttttaat 1052161 aatatttagc agcgcctttg tatcattttt gcttaatttg tagtatgtgc catccttcaa 1052221 aaaaacggct tgctggctgc cgtcaatcca tagtctgaat gagtcatacc ggtctttatg 1052281 aaacttgatt gtcccttcgt aatcaggggc tgatgttttt tctgtcttca cctgttttcc 1052341 ctgattcata atatccagca tatctttgac gtgctgtctt ttttcaatct cgatatcttc 1052401 ctggccgctt gaagacagtg tgatcaaatc cgcgtctacc gattgataca catcgcctga 1052461 tcggctgtaa agataaaaaa atgcgataaa cacaagaccg attaccacga tggctgccac 1052521 tatttttttc atttgcatca ctccaaacat tgttagtttt cccagcgatc ggggtttcca 1052581 tgcttaaaag ggtggaaaag tgcggaacac agcttggttc taagaatttg aatttatgat 1052641 tacaatagaa gtaacgggtt gatgtgagga gtgaggcgtt atgcgcaagt ggattgcggc 1052701 agcaggactt gcttacgtgc tgtacgggct gtttttttat tggtattttt tcctgtcggg 1052761 tgattccgca ataccggaag ccgtgaaagg gacgcaggct gatccggctt ctttcatgaa 1052821 gccgtctgag ttggcagtgg ccgagcagta ttcgaatgtc aagaattttt tattttttat 1052881 cggggtacca cttgattggt ttctgttttt tgttctgctt gtcagcggtg tttcaaagaa 1052941 aatcaagaaa tggatcgaag cggccgtgcc ttttcggttt ttgcagaccg ttggttttgt 1053001 gtttgtgctt tcgctgatta caacattggt gacgctgcct ttagattgga taggctatca 1053061 agtatcgctt gactataaca tttccacaca gacaacggcc agctgggcta aggatcaggt 1053121 tatcagcttt tggatcagct ttccaatctt tacgctttgc gttctcgttt tttattggct 1053181 gatcaaaagg catgaaaaaa aatggtggtt atacgcctgg ctgttaacag tgccgttttc 1053241 gctgtttctg ttttttattc agccggtcat tatcgatcct ttatacaatg atttttatcc 1053301 gctgaaaaac aaagagcttg aaagcaaaat tttagagctg gcagatgaag ccaatattcc 1053361 ggctgaccat gtatatgaag tgaacatgtc agaaaaaaca aatgcgctga atgcctatgt 1053421 tacaggaatt ggggccaata aacggattgt attgtgggat acgacgctga acaaacttga 1053481 cgattcagaa attctgttta ttatgggcca cgaaatgggc cattatgtca tgaagcacgt 1053541 ttacatcggt ctggctggct atttgctcgt gtcgctcgcc ggattttatg tcattgataa 1053601 gctttacaag cggacggttc gcctaacccg cagcatgttt catttagaag ggcggcatga 1053661 tcttgcggca cttccgctgt tattgctttt gttttctgtt ttgagctttg cggttacgcc 1053721 tttttctaat gctgtctcgc gttatcagga gaataaggct gaccagtatg ggatcgagtt 1053781 gacagagaac agagaagccg ctgttaaaac gtttcaggat ttggccgtga cggggctgag 1053841 ccaggttgat cctccggtgc ttgtgaagat tttcagaggc agccatccgt cgatcatgga 1053901 acggattcaa catgcggaga aagaagagaa tgcgccggaa catcaggatg ctgacaaata 1053961 aaaagaagca ggtatggagg aacctgcttc tttttactat tattgtgcag ctgcttgtac 1054021 gttgattaac ccttttccat agtagaaaga gtttccaaga tatgttgcag tgctttctaa 1054081 acgatcacgg acttgcgcgt ttgtccaagt cgggtgctta gaaagaatta acgctgctgc 1054141 tccggcaacg tgaggagtcg ccatggacgt tccgttataa gcgccgtaag tgcctccagg 1054201 aagtgtgctt tggatggaca cgccaggagc catcacatca agctcagaac ctgcgctgga 1054261 gaatgaagct ctttggttgc tgctgtttac cgcacctact gcaatagtag aaggatattt 1054321 tgcagggtag ccgactgtgc ttgtgcttcc ggatgaacct tcgtttccgg ctgcggcagc 1054381 aacgacgata ccgctggaaa cggctttgtc aacgactgtt ttcagcgctg tagaaccagt 1054441 aggtccgcca aggctcatgt tgataacatc catattgttg gaaatggccc actcaatgcc 1054501 gttaataatc cagctatatt ggccgcttcc tgttgaatca agcactttta ctgcatataa 1054561 tgatgcgctt ggcgctacgc ccagaacacc gattgagtta ttaagagcgg caatcgtacc 1054621 ggctacatgc gtaccgtgag aactgccgtc ctggtatggg tttgtttcag aaggtacgaa 1054681 gcttgctccg cctctgacgt ttaagtcagg atgagaagag tcaattccgc tgtcgataac 1054741 agctactttt acgttagagc ctgtgtagcc ttgagagtga agagccggcg ctttaatttg 1054801 agaaatgcca taaggaacag attgcgcata ttcatgtgca atatgatctt cttccacata 1054861 tgcaacgctc ggatcttttt tcaattcttt tacagctttt tcatccaatg ttgctgcggc 1054921 cgcgttaaca tacttaaatt gcttttgaac ctttccgcct ttttcagaaa taacatcctt 1054981 tttcttggcg gaactcatgg cactcattgt ctgtttaaat ccgacaatgt atttcttttc 1055041 tgtactgctt tttccggcag cctgcgcaga catgttgctg aacgccatcg taaagattaa 1055101 cgttaacgca aacaacaagc tgatccacaa ttttttgctt ctcactcttt accctctcct 1055161 tttaaaaaaa ttcagagtag acttacttaa aagactattc tgtgaattta ttgtaataga 1055221 tggaataata ttttagtaga cccatttttt tgagatgatt ttatctctat ttaggtatat 1055281 catctctcgc tatttccgta gagactcgaa ataactattt tcatacagaa aagaacgaaa 1055341 atagacatga gtaaatgttc attatgctga aatgtcatgc ttttttaggt taaatgctcc 1055401 tgagtcccgg caaattcctg tcgaaaaaat tcgttcaaat gacctgcgtg tgcttccgtg 1055461 agaacaatgg atattatcgt gatatttttt caaagcatga tgataaaagt attctgaaaa 1055521 ataaacttta cagaaaaggg atagaatgaa aaaattattg agagggagga agaaataaga 1055581 tgaacattcg ccaagcaaag acatcagatg cggccgccat tgcgccgctg tttaaccaat 1055641 atcgggaatt ttatagacag gcatccgatt tgcaaggggc agaggctttt ttgaaagctc 1055701 gtttggaaaa tcacgagtct gttattttga tagcagaaga aaatggagaa ttcataggct 1055761 ttacccagct ctatccaacg ttttcttctg tgtcaatgaa aaggatatac atattaaatg 1055821 acttatttgt cgttcctcat gcgcgtacaa agggagccgg cggccggctg ctttctgccg 1055881 caaaggatta tgcagggcaa aacggggcaa aatgtttaac acttcagact gagcaccaca 1055941 accggaaggc aagaagcttg tatgagcaaa acggctatga agaggatacc ggatttgtcc 1056001 attattgtct caatgtgccg gcgaagtgaa aatggcggct tgatgatttg gttttttgaa 1056061 cgttcttcgg ttacgatata aatgaaaagg agtgtgccga atgtcaacgt tatttcaagc 1056121 cttgcaggca gaaaaaaatg ccgatgatgt ttcagtccat gtgaaaacca tatcaacaga 1056181 ggatttgccg aaggatggtg tcctgattaa agttgcttat tccggcatta attacaaaga 1056241 tggtctggcc ggaaaagcag gaggcaatat cgtcagagag tatccgctta ttttaggcat 1056301 tgatgctgcg ggtacggtcg tctcttccaa tgatccgcgt tttgcggagg gggatgaggt 1056361 gatcgcgaca agctatgagc tcggtgtctc acgtgatggc ggattaagtg aatacgcttc 1056421 ggtgcctggt gactggctgg tgcctttgcc acagaatctt tcgttaaaag aagcgatggt 1056481 gtacggaacg gcgggattta ctgcggcgtt atcagtgcat cggcttgaac agaacggtct 1056541 gtctccggaa aaaggcagcg tgctagtcac aggagcaacc ggcggtgtcg gcggaattgc 1056601 ggtatcgatg ctgaacaagc ggggttatga tgtggtggca agtaccggaa accgggaggc 1056661 ggctgattat ttgaaacagc ttggtgcaag cgaagtaatc agcagggaag atgtctatga 1056721 cggaacgctt aaggcgctgt ccaagcagca atggcaggga gcggttgatc cagtcggcgg 1056781 aaaacagctt gcctcgcttt taagcaaaat tcaatacggc ggatctgtcg cagtgagcgg 1056841 cttaaccggc ggaggagaag ttccggcaac cgtgtatcct tttattcttc gcggagtaag 1056901 cctgctcgga atcgattcag tatattgtcc gatggacgtc agagccgctg tttgggagcg 1056961 catgtcttct gatctcaagc ctgatcagct gctgaccatc gtggacaggg aagtatcatt 1057021 ggaagaaacg ccgggtgcgt taaaagatat tttgcaaaat cgcattcaag gaagagtgat 1057081 tgtgaagctt taacaggatc agcttgcaga gaatgttatt tttctgcaag cttttttgtg 1057141 gacaggatga tcagctgctg aactgctgtg tcgcgaaaca agattttcct gtaagccgaa 1057201 ctttctcttc tcattttaaa aataattggt gataatgatt ctcattccgt gttatactac 1057261 tcttggacat cttaaccata gaaactacca acaggagaga ctggaacata tgaaaaaaac 1057321 actgattatt cttacagttt tacttctttc tgtcttaacg gctgcttgct cgtcttcaag 1057381 cggcaatcaa aacagtaaag aacataaagt ggcggtaaca catgatttag ggaagacaaa 1057441 tgtgcctgag catccgaagc gggttgttgt tcttgagcta ggttttattg atacactgct 1057501 tgatctcggc attacgcctg tcggggttgc cgatgacaac aaagcgaagc agctgatcaa 1057561 caaggatgtg ctgaagaaaa ttgacggcta cacatctgtc ggcactcgct cacagccaag 1057621 catggaaaaa atcgcttcat taaaacccga tttaattatt gctgacacga cccggcataa 1057681 gaaggtgtac gatcagctga aaaaaatagc gccgacgatt gcacttaata atttaaatgc 1057741 tgattatcag gatacaattg acgcttcgct tacgattgca aaagcagtcg gcaaggagaa 1057801 ggaaatggag aaaaagctga cggcgcatga agaaaagctt agcgagacaa agcagaaaat 1057861 cagcgcgaac agccagtccg tgcttttgat cggaaataca aatgatacca ttatggccag 1057921 ggatgaaaac ttctttacat cgagactttt aacacaggtc ggctaccgat atgcaatcag 1057981 tacgtcaggc aatagcgatt caagcaatgg cggcgactct gtgaatatga aaatgacact 1058041 ggagcagctg ctgaaaacag atccggatgt gatcatcctg atgacaggaa aaacagatga 1058101 cctcgacgcc gacggtaaac gcccgatcga aaagaatgtc ctttggaaaa aactgaaggc 1058161 agtgaaaaac gggcatgtat accacgtgga tcgtgcggtg tggtctctgc gccgcagtgt 1058221 agacggggcg aatgccattt tggacgagct tcaaaaagag atgccggctg ctaagaaata 1058281 aaagaaaaga caggcaaacg cctgtctttt tcttatttga taaagccgga taagtggctg 1058341 ttgatattat agtcttttat ccgccatttt tcttctgcaa attcaatgtt gctgaggcag 1058401 gcgttgacga gacgggtgct ttgaagctcc gggtcaccgc cggatatttc tgtcagcagg 1058461 gcgtgaattg ccgcaccgtg cgccacgatc agcaccttct tgtttggata cgcctgattc 1058521 acttttgcca aaccgcccat cagcctgtca gtgagttctt ctaaggtttc catattcgga 1058581 tagatgttat ctggatagcg ctttgtccgt tcctccagcg gcatgccctc cgcgtcgccg 1058641 taatcgcgtt ccttaaaatc atccatctcg actatcggaa gatgcagata ttcattaata 1058701 atttccgcgg ttcttttcgc tcttttcagc gggctcgtca caataatatc ccaagaaaag 1058761 tcctttacat attctccggt ttctcttgct tggcgttcac ctgttgcgtt tagcgggata 1058821 tcggttttgc cttggcattt ttgctgcagg ttccaatcgg tttctccatg tcttactaaa 1058881 caaacggctg tcataaaatc cccttcctga ctttattcat atcgctatta tactaaatcg 1058941 aaagcgtgtg tcctatgaaa aagcctatgc aagaacttca aataataaag ccagtccgat 1059001 tccgccgccg cttccgatgg ctgcaacagc atattgacag tctggccgtc ttttcgcttc 1059061 ataaaacaat ctggttacca gagctgcacc tgatgcaccg tacggatggc caagagctaa 1059121 ggcgccgccg cgcacattga tttttgaaaa gggaatgccg agttcttgcg agcagacaca 1059181 aattttgacg gcaaaggctt cattgatttc aaataaatcg atatcatcag gtgttacatc 1059241 gtgtgtatgt aagagctgac gaatcgcgac aaccggtgcc gcgggcggaa agttggggtg 1059301 aatgccgctg acagcgctgc cgataaaccg aagcacaggc ttaagtccca gggctgctgc 1059361 tttttcttct tccattacca aaagagcggc tgctccgtct gctatgccac tgctgttggc 1059421 tgctgtgact gttccggagc tggtgtcgaa aaccggcttt gcacggggaa taatcgcttc 1059481 tattggccgc gttttcaaaa atgcttcgtc cgtctccaat tccccgagag caacaacttc 1059541 ttcacggtaa aatccttcat catgcgcgtt cctgctgcgt tgatggctga gaagcgcgta 1059601 ctcatcctgc atgcttctgc tgatggaata gcgtgcagcc gtatattctg ccgcaatgcc 1059661 catgtctgga tcgccgatcg catctggaga aaagcgagcc cgttctgaaa aaggggattg 1059721 gctgctgctt tctgagccgc ccgcgatata catcgtgccg gctcccgctt gaataaggct 1059781 gcaggcatag cgcacagctt caaggccgga gccgcactgt ctgtcaattg tcattccggg 1059841 aaccgataaa ggcagtccgg cttgaagggc tgacagtctg gccaggttgc cgcctctgcc 1059901 agtagcgttt ccgagaatga cctcgtcaac ttgatcctct agctttcggc tgagacagcg 1059961 gatgatggga gccgccaaat cctccggcag gaagggcttc agcagtccgt tttgatttcc 1060021 aaagatcgtt cgttttgcat caacaataac cgcattcatt tatactgtac actctcttcc 1060081 agccattttt tcactctgga acgggcaatt tttccgctgc tcgtttccgg caagctgtct 1060141 gcaaacaccc attttttcgg aattttatag gaggctaatt tctgtttaca ccaggctttc 1060201 agtgttctgg cattagcgtt tccaagaatg acagctacag cgatttctcc ccaatactcg 1060261 tcgggaatgc caacgacagc cgcgctttca acctctgggc aggcgagaag cacacgttca 1060321 atttcttctg ggaaaatatt taatcctccg tacacgatca tcccgttttc tcttcctgat 1060381 atgtatagaa agccctcttc atcaacgtag cccatatcat ctactgtcat ccattcatct 1060441 ggtgtgctgc cgttcacata gccggaaaac ctcatcgggc ttttgacaaa tatttttccg 1060501 atttctcctg gctggcagcg ttctcctcca gcgttgcgga tttcgatccg gacattatga 1060561 aaagggcggc ccgctgaatg cggcttccgt ttgctgtctt ccggtgaaga aaacgtcaca 1060621 aaactaagct ctgatgtgcc gtaaaaatcg tacagcttga gatgaggcca tgcagcggca 1060681 agcttcttct tggattctgc cggccagtct gcgccggatg aaatgatttt gacgggactg 1060741 tcgggaaaac cctcaatcct tgcgagggcg tctgtcatcg tcggtacggt atagagaaca 1060801 ctgatggatt cacggcacag ccattccttc gctttggcag gagaaaactt tttcagcaaa 1060861 caaacggttc ctccgagaaa caaagtgctg acagccccat ataggaagtg agaggacatt 1060921 aacgctccgg gaatcagaac cttatcatct gatgaaatcg aaaaatctgt ttctgtacag 1060981 gtaaagctct ccatccatga gcggtgagat cgcgtaaagg ccttcggttt tcctgtcgag 1061041 cccgacgtaa atcccatata aaaagggtgc tccggatcaa tggtaggcaa gggatcagcg 1061101 gctgcctcag aaatatctgc catacagtta tccagcaata caacaggtgt ctggctatct 1061161 gtcagtttgt ttttgaaaaa ggctaaagta accacaagat ccgcattgct tatggacagc 1061221 cgctccttac attcagccgg gctccagcgt gtgtcgatgg gaatggccgt acatccagcc 1061281 gctgcggctc cggcaaacag ctgtaaaaac gcgagactat ttgggagcag gatcgccaca 1061341 cgattcggca tgctcggctg tgaccgcagc caatttgcgg tttgagagac aagccgatcc 1061401 caatcatggt acgtgatttg ctccgattca gtctggatcg ctacacggcc gggcgatgtt 1061461 tcggcagtag atgaataggt atgagtaatt gtcatgtatt gtcatcctcc ttttgtaaac 1061521 atcgtatcag aaagagacaa ggcttgagtg atttttatcg ccagaaatgc agatacagcc 1061581 gcttttatca aatcaccagg cacatatgca aggctcatga aggcggcctg tgacaaatca 1061641 atatgcatga taaaagcttg taccggtata ccaagcagat aaataaagat gatgccgaat 1061701 acgatatgag tgaaaaagag acgcaatact gtcaccttcc gcagcctgtt agcggctaaa 1061761 ctgatcagcc atgaagcgag gggataagca atcaaaaagc ctgcgctcgg tccgaaaaac 1061821 acaccaaaac cgcctcgtcc gccgggcaac agcggcgctc cgaaggcgac gagcagcaaa 1061881 aagacaagct ggcttaagaa agcagacttt ggcctgagaa tgctgcctgc caacatgaca 1061941 ccaagcgttt gcaatgtaat cggaacgggt gtaaaggata agaagagagg gggcataaag 1062001 ccgagcactg ccatcagcgc ggtgaaaatc gcaatatgca tcatgtcgat taatttcagc 1062061 atgtgaaatc ctccaaaaag taatcaaata tggttataca ataaatgcag gtaattatta 1062121 tgtcaactga tttttaattt aagtttacat aatgaacgca aaaaaaccgg ccgtatggca 1062181 gaccggtttt tgatggttat tcttctgtca ggatgacaag cgaatcaacg gaagcggcca 1062241 catgggaaac ggcgcggctg acttcctgaa gccctccaag aaaggcttgc agatcgacgt 1062301 cgattttgcc tgattgctct ttgctgattt tcatgctgtg gacgatttca tcgaataagc 1062361 ggttaatttg cgtcattttt tctttacttt cgctgactag ctcattcacg tctttgatat 1062421 gcttggatac aatgttgatt tgtgtattcg tattgttcac aagctcagaa acagtagaga 1062481 cggttttttt cgtatcctca gaaagcttcc gcacttcatt tgccacgaca gcaaagcctt 1062541 tgccgtgttc tccggcgcgg gcggattcaa tagatgcatt gagcgagaga aggtttgttt 1062601 gttcagctat gcctgtgacg atgccgaaga ttttttcaat ttgctgcgcg atttcatcca 1062661 gcttgaccat ttctttttcg atttggacaa ggcttgtgtc aattttgttc atctgttttt 1062721 gctggacttc tagctctttt tttccgccga tcgacttttc ttcaacagtg ctggatgtta 1062781 cagtgccggc tttggatgct tgagaaatgc cttcagattt gtccacaagc tcttgaactg 1062841 atctgcttgt ttctgaaaac agattggcaa tcgatccaga ggtttcttga attttctgat 1062901 gaagaaggtt tttcttttct tcttgttcat cacgggtctg gttgtactcg ctttgaaacg 1062961 cttcaaggac aagctgctgt tctaagttca agatttttgt tgttgcttta atggctttta 1063021 gcagttcttg ctgatttgta atggacgctt cataaatgtc aatcattgac aaaaggagct 1063081 cttgaaacgc acccatatac cattttggca aaaggccgat tcttaaatgg atggaggcga 1063141 ttcggttacg cttttcaata aattcatcat cgataacgcc tgcaaacatt tcctgaatat 1063201 gccgttttaa cgtttgtttt aagcggtcaa ctgagctgtg atcattaatg atatccatca 1063261 atgagctttc atggtcaagg tttttataaa acgcatcgac gatatttacg atattttctt 1063321 gaatgagtgg ctgaagctgc tctaacacat aaagctcagc atctcccaac ctgaccattt 1063381 tgagctgttt tttgacatct gcatgtttgt ttgtgagctg aatgcggttt ttttgttgtc 1063441 cgtttgaatc tgaaaagtaa gctgtttctt gttttctgtc ttttttaaat aacaatacaa 1063501 tgatccccct tgggaaaaat ataattttta ctttttggct ttttaagcct ttttcttttt 1063561 tatcggccaa gggaaacatg aatgaagctg cagatgaaaa atatttgaaa aaacgttcat 1063621 taaaatgaac ggtttaatcg agatctattt gttttaatgg tttaatggcc ggaccctcta 1063681 caacttcgcc agatggctta aagcgtgatc cgtggcacgg acaatcccac gtatgctcac 1063741 tgtcgttcca ctcgacctcg cagcctaaat gggtacaagt cgtatcaacg agatggaggc 1063801 agcctgtctc atcacgaaat gctcccgctc gcctgccgtt tatggtgacg gctttccctt 1063861 ctcctggcga aatgtcttca aattggacat caggcttttc aagctttcct tttatcaaat 1063921 gcttggcgac atctgcattg taggaaatca ctttctgcaa cccgggattc agatggaaac 1063981 gggacggcgt gaaaatgctt tcgtatgggt tttctttttt ctccacaagg tctgacaata 1064041 aagtggctgc gactgctgag gacgtcatgc cccatttttt gaacccggtc gctactagaa 1064101 tattgtcctc attttccgac atcggcccga taaacgggat tttgtcgatc gtcactagat 1064161 cttgggtgga ccaataatat ggaatgcttt cgatgccgat ggtgctttcg gccagttgtc 1064221 tcagtgtttc ataatgtgta gacatggctt ttccctggcc tgttttatgg cttactccgc 1064281 tgaagagaat cagcttttca ccgtttacaa ccgtatagcg gagcgccact gacggctgat 1064341 cgatactcaa atacatgccc tcgggatact cgatcttcgg cttgatggca aggacataag 1064401 atctgtcgga gtacattctc gcagcatata atccgcctcc gtcataaaaa gggaagtggg 1064461 aacagcatat gataaagcgg ctcttaatgg cgtgccggct ttttgttacc acttcgggcc 1064521 tttcgccttt tttgatatca agcgcaacgg tctcttcata aattcggccg cctttttgaa 1064581 caatttgctc cagaagcgct tttaagtatt gaagcggatg aaattgagct tgattcttca 1064641 tgacaagcgc cagcttagaa cctaagggaa ttggaagatc cttgataagg tctctttcaa 1064701 ttccgagctt tgtgtatgcc tcatgctcgg tgtggatttt ttgaacagcg ttttcatttg 1064761 ccgtataaag atatgcgtct tgctcgatcc attcacaatc aatttgatgt tcatccacaa 1064821 tgccttttat gtaatcaatt gcgttttggt ttgcttcata ataaagcctc gcatggttta 1064881 atccgaaatg gcggataaat tcgtcgtata tcatgtcatg ctgtgcggta actttagcag 1064941 ttgtatgcgc agtggttccg ttaagaacct gatttgcttc aatcaaaacg acacggaagc 1065001 ctctcttcgt aagttcatat gccgttgtga ttcccgtaat cccgcctccg ataatggtga 1065061 cgtcacattc agtgtcctct tgaagcgcag gaaaagaagg caggtcagtt gatgttttcc 1065121 agtatgtttc aggtgcttcc tttgcaaaat gttgattagc caagccgtta tacctccaat 1065181 cagatttatt cttaattttt ccatattcta tcttttcata cataggaagc aggcattgtt 1065241 cataacataa taaggttgaa aaggagtgat ttcattggcg aatcaaaaaa agaaaacatt 1065301 accgcctcag caccagaacc agcagcctgg ttttgaatat ctgatggacc cgcgtccggt 1065361 ttttgataag ccgaagaaag cgaaaaaatt agagggcaaa accgctatta ttactggagg 1065421 agacagcggg attggacgcg ctgtctcggt gttattcgca aaagaagggg ctaatgtggt 1065481 cattgtgtat ttgaatgaac atcaggacgc cgaggaaaca aagcagtatg tagaaaagga 1065541 aggggtaaaa tgcctgctga ttgcaggaga tgtcggggat gaagcgtttt gcaatgatgt 1065601 ggtcgggcag gcaagccaag tgtttccatc cattgatata ttggttaaca atgcagctga 1065661 gcagcatgtc cagcccagca ttgaaaaaat caccagccac cagctgatca gaaccttcca 1065721 aacaaacatt ttttccatgt tttacttaac aaaggcagtg ctgcctcatt taaaaaaagg 1065781 gagctctatt attaataccg cttcaattac cgcctataaa ggcaataaaa cgctgatcga 1065841 ttattcagcg acaaaaggcg cgatcgttac gtttacaagg tccctttccc agtcgcttgt 1065901 tcagcagggc atacgggtca atgcagtggc accgggtccc atttggacac cgcttatccc 1065961 ggccagcttt gccgcaaaag acgtggaagt gtttggttca gacgtgccga tggaacgccc 1066021 ggggcagccg gtcgaagtgg cgccaagcta tctatacctt gccagcgacg attccacata 1066081 cgtcacaggg cagacgattc acgtcaatgg cggaacaatt gtgaacggat aataaaaagc 1066141 caatccttga aggattggct tattcgctct gcttgagcgc tgcatattct ttagagagcg 1066201 taagaaacgc atctttatct ttttcgtcca aggctttgtt aatttggtcc gtcagcatgg 1066261 caagccgacg gttatacaag gattcatcga gcaccatttg aatgtaaata tccgtcattg 1066321 tgacatcgaa ttcttttgtt ttttgcgtgt tgcgggactt catgagctca gtgtacgatt 1066381 ttttctcttt cataaagaat ccccccaatg ccttttttat agtatatgga taacggtcga 1066441 aaaaatcaat aaatttttat aatttttaga caactaatac ttggcaatct atcgacatat 1066501 cctgcaaaat gccgtaaacc ggcaagtctt atgaaagtaa aatcggttta ttactagtca 1066561 tttagtacca ttaaatatca ttaaaagatg attttatctt aaatgttaaa aaaacctgtc 1066621 gttttacaaa aacagatgat agattattag tataaatttt gcagaaaaag gatggaggcc 1066681 ataatatgag tcagaaaaca gacgcacctt tagaatcgta tgaagtgaac ggcgcaacaa 1066741 ttgccgtgct gccagaagaa atagacggca aaatctgttc caaaattatt gaaaaagatt 1066801 gcgtgtttta tgtaaacatg aagccgctgc aaattgtcga cagaagctgc cgattttttg 1066861 gatcaagcta tgcgggaaga aaagcaggaa cttatgaagt gacaaaaatt tcacacaagc 1066921 cgccgatcat ggtggaccct tcgaaccaaa tctttttatt ccctacactt tcttcgacaa 1066981 gaccccaatg cggctggatt tcccatgtgc atgtaaaaga attcaaagcg actgaattcg 1067041 acgatacgga agtgacgttt tccaatggga aaacgatgga gctgccgatc tcttataatt 1067101 cgttcgagaa ccaggtatac cgaacagcgt ggctcagaac caaattccaa gacagaatcg 1067161 accaccgcgt gccgaaaaga caggaattta tgctgtaccc gaaagaagag cggacgaaga 1067221 tgatttatga ttttattttg cgtgagctcg gggaacggta ttagaaaaat aggaaggagc 1067281 tgaccgaaca gggcagctcc tttcataaag ctatgccgtc ggaattcctc cggtgatgcc 1067341 atatacctga gatgtcacat agcttgaatt ctctgaagct agaaatacat aaacatcggc 1067401 caattccact ggctgcccag cgcgatttaa tggagctggc ggcgtgcctt gtccgaattt 1067461 cgggatgttt tccgtcggct gtccgccgga aatttgcagc ggtgtccaaa ttggtccggg 1067521 cgcaactgaa tttactctga tgcctttgga agcaagctgt tttcccagtc cgacggtaaa 1067581 gccgataatg gcgtttttcg ttgctgcgta atctaacagc atcgggcttg gattatagcc 1067641 ttcaactgag gtagttgtga taattgaagc tccctccggc aaatacggaa gcgccgcttt 1067701 tacaacccag taaagggaaa agacgttcac ttcaaatgtt ttatagattt gttcagtagg 1067761 cagatcttcg atgttttcga ccgcttgctg tttgcctgca acgagcgcta gcacatcaag 1067821 tccgccgagt tcgtgatgcg actgtttgac tagatcttgg caaaaggatt cgtcgctcaa 1067881 gtctccgggg atcagcactg cttttcggcc ttctgcttca atcagctctt ttacctcttc 1067941 agcatctggc tgttcctcgg gcaagtagtt aatagccaca tcggcacctt ctctggcgta 1068001 agcaattgcg gcagcgcggc cgataccgga atcgccgccc gtgacaagcg cttttcgacc 1068061 cgttagttta cctgatcctt tgtagctttt ttctccgcaa tcagggacag gcttcatgtt 1068121 cttttgcagg cctggcggtt cttgatattg ttcgggaaat tcatcatgaa aaaatgcttt 1068181 tataggattc gtaagatttg aatcagacat cagcaacgct ccttttctgt ttggtgtaca 1068241 ttcgtatgtg tacccctgag cataagcaga aaaacatgtt ttggcagttt gaatagtgaa 1068301 ggaaaaagaa aacaagaaaa aacaaagcct tcttccatat ttatcttgtc aaataagact 1068361 atatgaatta tgataaattc gagctataaa tcaactaaat attgggtgtt gggagagtga 1068421 atcgtcatga aaaaagcggc ggcggttttg ctgtcactcg gtctcgtttt cggtttttca 1068481 tacggagctg gccatgtggc ggaagccaaa acaaaggtga aggtctataa gaactgcaag 1068541 gagctaaaca aagtatacaa aggcggagtg gcccgcacat cgaaggtgaa aaacaaaggc 1068601 ggaaaaacga agtacaagcc ttacgtttct aaggcacttt acgatgccaa taaaaacaaa 1068661 gaccgcgata aagatcttat cgcctgtgaa cggtaaataa gaaaaagcaa tctggtgtcc 1068721 agattgcttt ttttatgctt aggccgcctg atcggccgca gcgcttttcg ccttccttgt 1068781 cataaggctg actgccatca tgaccgtgat attcaaaagc agggcgacga tgccgacatt 1068841 caagtctttt gcggcttgcg gcagagccgg aaataaagtg ccgatcgtcg tttccgtcat 1068901 tgtaatataa gtaactgctc cgacacctgc aataatgccg gcgaaagctc cttgctttgt 1068961 caccatatta tgcttgagca ggctgaacaa aagggcgggg aatagctgtg tgacaaggct 1069021 gtagcccatc aaaagcagcg taacgatggt attcccgcct ttgaaggtaa aatacaccga 1069081 aatcagcgca atcaccggca ctaaaaactt agcaagcgcc gatacttgct gttctgtcgt 1069141 gcggggcgcg attaccttgt acacattttt tgcaaacagt gtggaggcgg acattaagat 1069201 catagaccct ggcacaagtg ctgtcagcag tccggcagca ccgataattc cgacaaacca 1069261 agggtcaaat gcttgcagag acagtctcaa aagcgacaaa tccccgtctg cgccattcag 1069321 atctggaact tgcaggatag ccgcaaagcc gacgaaaagg acgaagagca ggaccagctg 1069381 gtacaaaggc atgatgatgg cgtttttacg aaacactttt gggttttcgg ctgaatacga 1069441 agcggaaaac gtgtgaggcc acatgtaaaa accaagcgct gtcaagagta cggttgaact 1069501 gaaccaggcc acactttgtc ccgattcggg gagcgtaaga aagccaggct ttgccgtttc 1069561 aatctgctga aacatgtctt gaaatccgcc gtagtaatga attggcaaat acacacctaa 1069621 aaacagaacg acaaccagaa tcatgatgtc cttcacaacc gatatccagg cagacccgtg 1069681 aatgcctgaa accataacat aaaccgtgat ggaaacagcg ccgatccaga tggcagcggt 1069741 cggggtgatt ttgccgtacg aggtttccga tacaatcagc ccgaggcctt tcagctgcag 1069801 tacaagatag ggaatgagtg cggcgatgcc gaccagtgaa acgagaatgc caagcagcgg 1069861 actgttgtat ttttttgtga aaaaatcaga ctgcgacatc agtttatgct gtttcgcgta 1069921 cgtccaaact gctggaagaa gccagtaaga aaggatgtag gccagacatc cgtaggcgat 1069981 gatataaaag gctggaccgc cttttccgta ggcccagccg ctgccgccga gaaacgtaaa 1070041 agtagtataa atttcgcctg ccatcaaaag gaagacgaaa acagttccga agccgcgccc 1070101 tccgaccgtc cactgctcca ggttcatgtc ttttcctttt tgggcgcgta taccgagaaa 1070161 aatactcaag agcaggacac cgaagatgat gatgagagct gcattcattc tgcttcctcc 1070221 tttttatttt ccttgtcgag gacatacaca atcgccatca gcgcagaggt caaaagagcc 1070281 cacatcacaa tataggcaag aataaacggc atgccgaaca catagggggt caccttattt 1070341 gcaaaaggga tgccgagtaa gattccgata aagggtaaag cggcaagaac gtgaatcagt 1070401 ttcatagaat cctccttcta tttaggattg aggtgtacaa gcctaagcgt actgaaaatg 1070461 atgtcgcaga tatcgcagca catgtcattt tttggagtga aaggctgtgg ttcgaattat 1070521 aaataaattt attttgtttg tatagtgtga attgtctgaa attaatgctc tgaatcgccc 1070581 gaagagggaa cgggcagtat gattcaaaag gctcagagtc tgtctggggc aaatagatag 1070641 tatgttaata attcgctgac ctgctcacgg attcgcggat taaaatagcg atggttttct 1070701 tcataaccgt cgatgacaaa tgtatagagt gtaaaggcct catcgcgttc cgtctcgcgg 1070761 attgcaattt ttcttttcct cagttctttt ctgacctcca tcaaatcctt ttgtgctatt 1070821 tttaatgatt cgctgataag ctgtttataa ggatgcttca attttaatgt gctttcttca 1070881 attccggcga gatcacggtt aaaaatcgta atggccatgg gcaaaaagag agcccgttca 1070941 attaaatcgt atatttcctc ctgcagattt ggcatattga ctccttcttt ctaagggaac 1071001 gtttgttcta tttgtattct atatcggctg gtgaaatgtt tcaagacaga aaaaatcacc 1071061 aaaacttttt agttttctgc tgataatgtg tagaataagg atagacaaac ccggtaagga 1071121 gtataaatgt tggagcattt tttatcctat ttgacacaag aacatttaac tgaattattt 1071181 caaagctata gggctttcgg tccgctcatt gctgtgctgc tgcctttaat tgaagcattt 1071241 ctcccgtttt tgccgctgat cgtgtttgtg gtggcgaata cgaactcgtt tggcttgtgg 1071301 gaaggattca tcctatcctg ggcgggatca actgctggtt ccattctcgt ctttttgatt 1071361 gtccgtcaat acggacagag aaaattgctt ggatttatcc gcagtcatcc gtctgtcaga 1071421 aagctgatgt tatgggtgga aagacacggc ttcggtccca tgtttcttct gctttgtttt 1071481 ccatttacac cgtcagccgc ggtgaatgtt gttgccggtt tgtcaaggat cggaacgcgg 1071541 ccgtttattt tggcggcagc ctcggggaag cttgtcatga tttttatgat cagcttcatc 1071601 ggatatgatc tgcacgcgct gattacacag ccgattcgaa cggtcatcgc cgtattggtg 1071661 atcactgtct tatggtatgt cggcaaaaag gtggagcggt atctgcatgt aagagccagt 1071721 cagcgtgagc atgatggagg gagacagtaa catgaaaaaa cggttttggt ttcttgccgg 1071781 tgtagtgtcc gttgttctcg ccattcaggt taaaaatgct gtctttattg attacaaggt 1071841 agaaggcgtc agtatgaacc cgaccttcca ggaaggaaac gaattgttgg tcaataaatt 1071901 ttcgcatcga tttaaaacca tccatcgttt tgacatcgtc ctttttaaag gccctgatca 1071961 taaagtgctg attaaacggg taatcggctt gcccggtgaa acgatcaaat ataaagatga 1072021 tcagctgtat gtgaacggaa agcaggttgc tgagccattt ttgaagcatt tgaaatctgt 1072081 ttctgccggc agccatgtaa cgggtgattt ttctttgaaa gatgtgacgg gaacaagcaa 1072141 ggtgccgaaa ggaaaatatt ttgtcgttgg agataatcgc atatacagct tcgacagccg 1072201 gcattttggt ccgataagag aaaaaaatat tgtcggtgtg atttctgatg ccgaataaaa 1072261 agacgctaat tgaagaggcg tctttttgta tgccgtttgg aaaaatgtgt tgaagaaaaa 1072321 tttgtaagga gctataatca aaattgttac ctgtgtaaca aaatttatat atttttttga 1072381 ctggagggcc gtttttattg gtttttgttc gtttttcatg aaacaaaagg agtggtgaat 1072441 gatgatgaaa tatgaagcag tgattatagg aggagggccg gttggattta tgctggcttc 1072501 tgagcttgca atagccggag tgggaacatg tgtgattgaa cggcttgaaa aacctgttcc 1072561 gcattccaag gcgttgacgc tgcacccccg aacgctggag cttcttgaga tgagagggat 1072621 tttagagcgg ttcgtatcca agggaagcaa gatacctacc ggacattttt caatgctgga 1072681 tacccgtctg gatttttcag gcttggatac gagctgtcct tacacgcttt tgctcccgca 1072741 gtccaaaaca gaaaagcttc ttgaagatca tgcacgaagc ctgggaacag aggtgtttcg 1072801 gggtgccgag gcgctggcgg ttacgcaaaa cggggaagcg gtccaaacaa tttttaagga 1072861 tcgggacggc agtgtacgga cgatcacaag caagtttgcc gttggggcag atggcgccgg 1072921 gagtaccgtc cggaaacagg cgaaaattga gtttccggga acagacagca ctgtcaccgc 1072981 tgcgcttggg gatgtggtgc tcctttctcc gccgccgtca ggtgtgctgt ccctttgcac 1073041 aaaagagggc ggtgttatga ttgttccgtt atctccagac cgataccgtg tcgttgtgat 1073101 cagcccttat cgcacacaaa cgccgaaaga tgtgcctgtg actgaggaag agctgaaagc 1073161 tgacctcctg cgaatttgcg gaactgactt cggtttaacc gacccttcgt ggatgtcgcg 1073221 gtttgggaac gccgcgcgcc aagcgaaacg gtatcgggac ggcagaatct ttcttgcggg 1073281 tgatgccgcg catattcatt ttccggcggg cgggcaagga ctgaatgtcg gccttcagga 1073341 tgcaatgaac ctcgggtgga aactggcggc ggccatcaaa ggctctgcgc cttcttggct 1073401 tttggacagc taccatgatg agcggcatcc ggcagcggaa gggctcctca gaaacacgga 1073461 ggcacagaca aagctgatcg atttcactca agcaggcctc catttgcgaa gcatgatgtc 1073521 ggagctgctg gccttccctg atgtgaatcg atatgtagcg gggcaaattt ctgcgctcga 1073581 tgtcagatat gaagctgatc gtaccatgcc gccgaatcgt ttgaacgggg caaggctccc 1073641 tgacatgaag ctgattcttt ccgacggcaa ttcggaacgg ctgtacagct ttctccaaaa 1073701 cgggacattc gttttgctgt cattgaggca ggaagctgat gatcatatcg aagtaaaagg 1073761 cttacgtacg gtaaccgcct cgcttgcaga accgaatgaa aagttgcgga atgtgcatac 1073821 catattgatt cgtcccgatg gacatgtagc ctgggcggtg gatgcatcag cgcccgattg 1073881 ttccgaggtg attcaaaaag ggatcagccg ctggttttcc gtcaccagcc gagtataatt 1073941 caattcgatt gtttcatctg taacaaaacg gtatgataga agaaacaatc gaatgaaaaa 1074001 ggatggaaaa cccgatgaac acagatcata cgaaacgcaa tctttttgaa ttgtatgcgg 1074061 agctcattca tcagcaggag aaatgggagg ggcttattaa agccttttta tctgacgaat 1074121 tgaggaagct ggatgtagag cacgggagta aatctcaatt gacgatgaca gaaattcatg 1074181 ttctatcctg tgtcggggac aatgaaccaa ttaatgtcac gtcgatagca gaaaaaatga 1074241 atacgacaaa agcgactgta tcacgcatca gcacaaaatt gctcggcgca ggcttccttc 1074301 acagaacaca gctcagcgat aataaaaagg aggtctactt ccgattgacg cctgctggaa 1074361 aaaagctgca cagtttgcac aaatattatc atcagaaggc tgaacagcgt tttctgtcat 1074421 tttttgaccg ctataccgag gaagagattc tttttgcgga acggctgttt cgggatctgg 1074481 tgacaaaatg gtatccgtcg tcagaagaaa ttgaaggggg gcttcctagc atttttaaat 1074541 aaaaaacacg cactgcggtg cgtgtttttc gctttgtttc tatctttttc aaggctgtaa 1074601 cgtaaatcag atttcctctt gaagaatgaa attcaagatg ttcaggaatt tgcactgctt 1074661 atacgatatg tctattagta tctttatttt atacgttttc tactgtgttt ttgatgcttt 1074721 gttttcaagt gaaatagggt cttctgtttt agttctccta atctttacag aaatacctac 1074781 tagaatgacc gccatagttg taaatattcc catggttaat aagatcgtat cctggtttaa 1074841 actccatcca attaagaaag agatgatcgc tcctccgaaa cttgccgagg caataaataa 1074901 acttgtaact tcgtcaacgt acttctgaat aatgattgat gctagtgtta aagcaatggg 1074961 aaatatcccc gctatactta ggccaatcaa aaatgtacca ctcaattgaa gtattgggtt 1075021 acttatataa gagaaggcaa tcaacaaaac aattaaacaa ctacagctaa aaagaaggta 1075081 tttggaaaaa tcaagccttc tacttacgaa accaatcaat attcttccta tgatgatccc 1075141 tacccagaaa aaggagacac ttataagact aatttgttca ttgtcttggt ttatcatgat 1075201 tgaaggtaaa aagttggcaa aatttgtttc aattccagca tataggaaag cgaaaaatac 1075261 aaaaaagcct aattgctttg atttttttct atctcctata aagtattgaa atgctcctcc 1075321 atctggaaag gtcacttgtt ggttagcatt cttagcgtac tctcggttct tagacaagaa 1075381 aattaaccac cctacgaata ggacgaataa aaaggtgaat atacagtaat atggtaaaaa 1075441 ccagttattg atatctatga aggaattaat taataatggg aaagataaag cgcctaatcc 1075501 aaagagaact tccagcttac tcattttttc tgcattactt tcgaaattag caataacaaa 1075561 tgaaccaact gtcgtttcta atgtgcctgc tccatatcct aagagaaaag ccattacaat 1075621 aatataatac caatccttgg ttagaaaaaa gatacttaac gctacaagca ttattgtcaa 1075681 agctaaagta agtgtcctaa aatgactgta tttcttaatc attaaaggtg cgattaatac 1075741 tccgcttaga aatccggtaa actggaagaa gattatgacc gaaatatcat ctgttgtctt 1075801 gttaaaagcc tctaataaaa atggtgtcaa actccctgtt gatatatgga taatacctac 1075861 tgtaaaaaag aaagcatatc caaataaata tgtccctctt aacattcatt acacccctat 1075921 atgaaaaagc aggaaagtaa attcctgctt ttttagtaac ttctctcttt gaaatactag 1075981 ttgactgctg aaacagacat gggttgagag ttgctgtctt tctcaaagaa catttctaat 1076041 acttcctgag atctaaaacc atcactaaaa gaagggatct caacccaatc attctgagtt 1076101 gatgcaatcc aattgattaa ctcgcttcta aaagaatcag cccatccata aaactcgttt 1076161 ggcggatcgt ttaataggct ttgcggtact gggcagtcta ccacgttcaa gccatctatg 1076221 agcttgtaaa cgtgaggatt acctgtgtgg tatttaaact cttttttgtg tccaactacc 1076281 tcaatgctaa aaccacagtc ttcaggtaca gaacactttg atgtgatgat atttacaaat 1076341 accttgttct tcagctggcc ataaatttct gcatagtcat ctacaagtac ctgtttatcc 1076401 tcttttgttt ttacatttgt gttcatcttt gcccttactg attctgtgat gaaatcactc 1076461 tcgaacaaat accataccat gtcaataagg tgaataccca gatcccccaa tgatccactc 1076521 gtcttcttac tattagcgtc atctctccaa gtaaacttct tacgtctaag tgcactattt 1076581 ttcttgaagt gtacttttat ggacagtatg ttacctagtt cattattgat aattaagctt 1076641 tttaagatat ttacgtaaga taaatatcta taattaaatc ccatactggc tcttacgctc 1076701 aacctttcag cagtatcttt cattatgctt gcttcttcaa gagaaatagc cataggcttt 1076761 tcacataata catgcttatg ttttcctaat gcttgcaaag catgttcttt atggcaaaag 1076821 tttggtgatg ctacaattaa accttctgag gcatcaatta gttcatctac gttttcaaat 1076881 gacttcccgc cgaaagtttt cacaaagctt tccgcatttt gttgatttat gtcatatacc 1076941 cctactaact ctgcattttt tattgtagat aaagcagttg catgcgctct tgcaatacca 1077001 cctgcaccta tgatgcctat cttcttcatt tttatttcct cctcatgatc caattaattt 1077061 ttttaaggta ttagtaattc cttttgagta ctcactatca gttataaggt tgtgcaagtt 1077121 tttggcttcc tgtgttgcat tttttagcag atatccattc cctactgtct gtaacatacg 1077181 aacatcattt ccactatccc caaatgcgat agctctttcg gtatttaggt tgtatttctc 1077241 taacataaac gttacaattt cattctttcc tgtccctatg gggataaaat ctacatcata 1077301 gctgtcttct ggatcgcctg ctaagggatt acaccgattt atatttactg aaacgccgta 1077361 ttcttcgcag attttttcaa tagctaatag gtttttcttg tcgtttattt catcttgttc 1077421 ctgatagtag aagttatgct tataccgtga ctttcctaat tgggtttgag gattcaaaag 1077481 aatgttatga ttttcatgca gctgtttcac aagtttttca accttttctt tactaaaccc 1077541 ttcatttatg cgactgttcc acttgttatc ttgctgaccg aagttatgct ctgaaaagta 1077601 cgtaatttca gttccaagat cactagctat aaaatgcgga aaatatctaa attttcctcg 1077661 tcccatttta tcgagaatag attctatact gctcccagta acccatccga ttattagctc 1077721 cccatcttta cttttttgtt ctagatagtc ttcgagttca tagatgtctt gttgcttttg 1077781 ttcgtcgatt gtatgcggaa aatacgtttc atcaaaatca caaaaaacaa tatattgagg 1077841 atgttcaacc gtggataacg ttttatactc cgatttcttg cttaataaca tgaaacagtc 1077901 cctccattac tctgtcttgt tcttctaaag taaatgacgg atataaaggc aaatgcagta 1077961 cctgactatg agccttttcc gtatgaacca attggagtcc tgcatacttg tcctgtacta 1078021 aaggagtttt ttgcatatga gaaagtattg gataatatac atctgtttga acaccaaaat 1078081 cttcatttaa tttagtcatg atatctgccc tatcttctgt tcttacctta ataggaaaca 1078141 gatgccatac atgatcttca cttaattctg gtaattcaat atagccttta ttctgcaact 1078201 ctgctaattg ggtaatgtat ctatccgcca agaacaatct tttgaagttg tttaatgaaa 1078261 ggtacttcat tctctctaaa ccaattgctg cctgtaaatt gtccattttt gaattaaatc 1078321 caaaattgat gactttctta ttttttacat ttacttcaaa accgtgataa ctaaattgaa 1078381 tgcatttttt agcgagttct tcattatcag ttgctattgc cccagccttg ccacatacac 1078441 caaaattctt atagggatta aaacttaatg tagtgatgtc tgcatacttt cctaagtctg 1078501 tcagtccaat tccttggcag gcatcttcaa ttacttttaa tttataacga tttgcgattt 1078561 gacggatatg ctgcatgtct gaatgttttc cgtataaatg cacaggtaga ataaactttg 1078621 tataaggagt tattgcttct tcaattttgt caggatcgat gcagaatgtt tgtgggttaa 1078681 tatctacata gataggaacg cctcccgaag ctaacacagc attttcagta gctgaaaagc 1078741 tattagccgg catgataact tcatcccctg ggtttaaccc taaagccaat aaacctatca 1078801 taatagcatc ggttccactg ctggttgcaa ttacatacct tttatgtaaa tatgtagata 1078861 aaactttttc gaattgctct aaatagggac cactcgtaaa ttttccagtt ggcaaaactt 1078921 cagttaatgt atttaagata tcttccactt catcattggt tattaatctg tctacaggca 1078981 aaaaagggac tttactgatt tcacgatttt tttgatagtt gaaaaggtca tgttcaatat 1079041 ctatcttttc ttttaatact tgtttccacc gctcgtttac aatactgtct tcaataacaa 1079101 gttcttttcc ttgtacgtca ccttttaagt gttttaatag tgacatgttt tctttgcttt 1079161 tacctgaaat cttaacctgt ttttgcatga acagtacctc caatgatttt ataatctaaa 1079221 aatttattac aaatttatcc tagtttctga aatcggtaac atgtcaacaa cttttttaag 1079281 gaagggaaaa tatgcctaca attgatgaaa tagcaaaatt atgcaatgtg tctaaaacca 1079341 cagtgtcaag agtattgaat aatcatcctt atgtgtcgaa agaaaaaaga gatatgatct 1079401 taaaggctat taacgaactt gactacactc ccaattattt agctcggaat tttaggagaa 1079461 ataagacaca aacgatagct ttatcggttc cgagtatcga ccatccattt tttgctcaat 1079521 taataaaagg ggtctctcat gaagtactgt ttaagaatta caaggtaatt gtatttcaga 1079581 ccttttatga caaacagacg gagctagaat tactagagtt attgaagcat aaagaagtgg 1079641 atggcattat tcttgggact ttagaaaatg aatgggatca gatatcccct ttcttaaagt 1079701 atggtcctat cttattatgt aatgaatatc atcactcagc ggacatcacg ataattgggt 1079761 atgatgaatt tgaagccgca tacatggggg tagtacattt aattgaaaga gggcataaaa 1079821 aaattgggtt ttgttttgat actccatata gcgaagctca atgtcagagg aaagagggtt 1079881 atttgaaagc tttacaagat tacaatttac atcatagaag cgaatggata ttcggcgaaa 1079941 tgtttaatat cgaggatggc tttcgtgttt ttcataagat aaaggatcta aaggacagac 1080001 cctcagcaat atttacagga aatgatcaag tcgccgcagg gattattaaa caggcgatga 1080061 aaaatggctt taaagttcca gaagacttag ctgtaattgg ttttgacaac caattgattt 1080121 gccaagtcgt tactccgacc ataacaacaa ttgatatccc cgtaatagaa ttaggccaac 1080181 aggctgtgtt gaaaatcatc gagtccattt cgggtaatgc ctctttaaac agaagaatta 1080241 ttaaactgcc aacaaagctt attataagag aatcaacgta acgatagatt tccctttaac 1080301 attttatatc tttatataag aaaaagaggt tattcatttt aacctctttt tcaatcgtaa 1080361 gtcgtcaatt atttctttca tttcaccctc tggcagcact cacttcaaat ctgatccatt 1080421 aacaacgaaa tatccgctta tatttcctca tctcgatggt ttgcgaatta aaagttcttg 1080481 aacccttttt tcaactaggc actactgccg ctgattgagc tctttttgtc ttttttttca 1080541 ccatgaagat ggtgaagcag gcgataaaac ggcggcagca gggcaataac cagaatgacg 1080601 cgaatgacct gaaccgcaac gacaaaggtg gaatcagcat gtaaggtaac tgacgtcgtc 1080661 gccatctctg caatcccgcc gggcgcaaat gccagaacag aagtgatgag cgaaattcct 1080721 gtcagctcgg aaacgatcac ggcgctcaaa aacattgctg cgattaaacc gacggacgag 1080781 acaaacccga cgatgataat acgggtgacg ccggcaaaca tgcttttgta catcttagag 1080841 ccgatcgttg ccccgagaaa tacttgtgat acatggttag cttgtgacaa ccaccatgcc 1080901 gtcatgtcgt gccctgtcac cgcagctccg ccaacatgta caattgctac accgagcatg 1080961 ctgccgagca gccatggagc tggaaatttt aaaaatttcg cagctttgca agctccccag 1081021 gcagcgagaa taagaatgac ggtccacaaa acgggagcga gcctaaaatc tgtcgttgca 1081081 gaagaaatcg tctctgctgc ggcacttgcg gtacgatctt gttttgtata gatcagaatg 1081141 actaaaaacg gaatggaaag caccacgagc agcacacgca tcatttgaac gaggctgact 1081201 atagcggtat tggcgcctac ttcctgtgcg atgctcggca tggcggaaag tccgccggga 1081261 gcggtgccga caaagctagt catcatatcc gttttgctga aacgccaaag cacatatcct 1081321 gacagcatgg ccagcaggat agacaatatc agcataacgc cgactgaaaa ccaatggtct 1081381 ttgagaacag agagaacgga taaattcagc ttttggccca attcgatgcc gaggatcatc 1081441 tgcccgaggg cgagccatcg tcggttaatt cctttttggt ctggtgccat catcagccat 1081501 gccggccgta tcatggcgag gcagcaggcg acaatcagtg ttccgatcat ccatccaatt 1081561 gatattccgg ttaatgaaag aataaacccc ccggctgcac tgattgcgat aaaccataga 1081621 tctttgagga gattttcgtc tttcttcaat gtaaaaccct tcttcctttt tcacgtaaca 1081681 ctccaattgt tcacgtagtg aatgtattta ttactatagt atatttttgt tgataaagaa 1081741 attatgaatt attttctata agcgattcac ttttcttatg accttgtgtt cgagcttttc 1081801 tattgtgtaa gtcagagata aacccgctgt cagcagacac acggcaagag cgtaaaaaat 1081861 cacttctccg ccaaatgatg tcaggatcag cccgcctgcc agcggtccga ttgagcggga 1081921 tatatcccaa tgcagaccat agacagcata aaaccggccc agcaaatgag gcggcgccaa 1081981 tttcgatatg aaggtctgga tgtgggttag cccgatgctt tcaccaaccg tcatcaccgc 1082041 tgccgtcact aaaagcattg tcagagaggt tgagcatgca aagccggctg ccgcaaggga 1082101 gtagcaaata taagtaatga agaggatcgt tttcattgaa agcttttcgg tccctttgac 1082161 aagaggtact tggagaacac agctgaataa agcttttgct gctgaataga tggtcagcat 1082221 ggacagataa tcagaaaaca tgtttttgct gaacagcctg tatgttgttt ctgtttgtgc 1082281 atataacatg ctgatgggga gagaaagcag caaaagaagc aggacaggcc tgtatattgt 1082341 aaagctcgcg gacattttcg gggtaacagc tgggtgtagc ggctttgtct caggcagttt 1082401 cagtgcagcg atcagaaagt agataaacaa tgctgcagca tctaatgcga atatccacac 1082461 ggggttatga ttgtacagca gcatccccac tagcggtcct gccgtcagac ccgtcgaata 1082521 gatcgcattg atgaccgcaa acacttccga acgtctgctt tccggcgtgc tttcagcgat 1082581 ttgggcgcgg gaagcgggaa tgtacaacga tcttccgatg ccattcatga catagagaat 1082641 agcgaaaaca tacgcatgct cagcaaatac aaaccctgtc attgccgctg attgaagaag 1082701 caatgcggtc aaaatcgctg tgcgccgccc aagccgatcc gtcacccgtc ctgcagcgag 1082761 cgtcaggaaa atatcagcaa atggctgaag gctgatgatc agcattggca tcatgatact 1082821 gccgtttaat tgttcatgca gatacagcac cataaaaggt cccatcattg cacctgtcag 1082881 gcttgtcagc aattcgccga aaaagcggag ccgaacggga gcggtatatc tcgattttat 1082941 agagtgaaaa ctggtcaaca tgtgatcgcc gcctttcgct gtttgatata gtagtagtgt 1083001 atagaagggg cggcggccca aaaagtgaag aaaagaagag ataaaagttc cccttttgtc 1083061 gggaggtgcg gggattgaag ctgatagagc actacgtggc gcttgtaaaa acaggctgcg 1083121 ccgagtatgg gcaaatgaac gaaatgacgc tcactgagat tgccgactgt ttattttgta 1083181 cagaaagaaa tgcaaagctc attttacata agctggagaa cagcaattgg attatccggg 1083241 aaagcggggc ggggcgcggc cgcaaatcta aaatcgcgtt tcttcggagg cctgaggaac 1083301 tgcttcttca aactgcaaag gaatatacca tgtcaggaaa gcttaaaaag gcaaaggagc 1083361 tgcttcagca gtatcagtcc gcgtttccag ggcttcaaaa cgaatataac atgtggctat 1083421 cagaggtatt cggatttgtg acggagacag gcgagaatgg ggcgaaggat gtcctgcggc 1083481 tgttcatcac gcctgaatct gtcagcagtt tggatccatg ccaaatattt ttgcggtctg 1083541 agggccattt cgtcaaacag atatttgata cactcttcac gtttgattcg gatatgcagg 1083601 agccgaagcc tcatttggtt catggatggg aagaggtcgg aaaaaaacaa tggagatttt 1083661 ttcttcgaaa aggtgtgtta tttcataatg gacagccgct gacatcgcgg gacgttgcgt 1083721 ttacatttca gcgctttttg gaactggctg acaacccgta taaatggctt ctgcacggag 1083781 tgaaacaagt cttagaaaag ggcccttatt gtgtggagct catactcgat aagccgaatg 1083841 cgcttttgcc gtatgctctt tgtgatgaac ggctgtccat actgccggca gaacagggcg 1083901 gcgggaaaaa tggaacaggg ccttttcaga tgaatcagca acatagcggg atgcttgtgc 1083961 ttgaagccaa tgagcgctac ttcaagggac gcccctattt ggatcgcgtt gagtttgtgt 1084021 tttctgagca agccggagag atgaacggtt ttaccattca agaaaaacaa acatgtcctg 1084081 agcagcaaac tgtctttgat gagcggcatg ttcagtattt gtcgcttaat ctgaaaaaga 1084141 aggggcctct tcagcaccga agctttagaa aagcgctccg gctgctgatt tcctctgaac 1084201 ggctcgttcg tgaagcggga gggcaccgaa gaattccggt tacgtccttt ttgcatccga 1084261 gtccttttga gtgggagggc gtttcgccat ctgaattgtt gaaaaaaagc ggatacgagg 1084321 gcgaaacaat cgtgctttat accttttcgg aaacggatca tcgtgaggac gccgaatgga 1084381 ttcaaaatat ttgcgcccag cacggtatca ggcttacact tcaattctgt gatgctgctg 1084441 atctgcgacg gccggaaatc gtgcagatgg cggatatcat tcatgacagt gcgacgtttt 1084501 atcaagacag cgagtttggt tttctgcatt tgctgctgtc ggagaacagt ttcttgtatc 1084561 agcatctatc tgaaaagctg acacagattt gctcaggaat gacagagcgg atgttttcca 1084621 tgcctgaccg ctgttcgaga atcaacatcc tgcgtgacat tgaccggcag atgatacagg 1084681 agctgaacgc gatcccgctg tatcaaaatg tgctccaggt gacatcaagt aaaaatgtaa 1084741 aaggcctggt gcttgatgaa gagggatgga ttgatttgta ctccgtatgg ctgtccaaat 1084801 aaaaagaggg ttcttttttg aaccctcttt tttacgctgc catgctgcgg cattgttcag 1084861 cacaggtgaa gcaggctttc gcacatgctt ggcaatgatc atgatcgtgc tttccgcatt 1084921 cagtgccgca tgcttcacaa atatcggcgc aaagtgcaca aatttctttc ataaacgggc 1084981 tgtccgtttg catggctttg accgccagcg cgcaaatatc cgcgcattcc ctgtcaagcc 1085041 ggatgcatcc gctgagatga tgctgcacgc tttcttccaa gcatttagtg aaacaatgat 1085101 tgcaagcctt catgcaatcg atgcaagcct caatacaagc ctcagaatat tgctccatgg 1085161 ttgattcccc ctgtatgaca gtatatggtt ttatgtttca cggctgcatt tgaaaaaaac 1085221 aggggagtgt gtttttagct aaggggatat gtacatatac cctgaatggg tatatctaac 1085281 gttccatcag atagtatagg aaccagacag cgtgattttg ttcatcacgt gctgcgcgcg 1085341 taaagacgcc tttcgctttt aagtttgacg tttcctcggc cgcacgcaag taaaagtcga 1085401 cggtttcttg ttcatcttta aaagcggcgt ccagtcctct tgtgaaattg tccgggcatt 1085461 cttccgtttg tttcggcatg atgtgtttgc cggtaattga accatacagt gtggaaaatt 1085521 cacggaggtg gcgaatctcg tcacgcctga tttcttcaat ctgttttctg acctcatcgc 1085581 tgtgggcgag ttcggcaagc ttgcggtagc attgaatagc actgaattct ccgttgatgg 1085641 ccttctgcaa attccgaatc aaaacaggat cttcccggta tggcaccgga tagggatagt 1085701 agctgtaatg caaggggatt caactccatt cttaggaatt gggcttctgt aaaagtatat 1085761 gttgggcagg gagagatgtg cggagataat cagcttttta tatgtgaaaa ggccgttttt 1085821 accaatagat cagattggtc attttcgtca acattcgata aaatatagag agataaaaag 1085881 agaggggtct tctaatttgg gagcagagtt tttagtaggc aggtccggga gtggaaaaac 1085941 gaagctgatc atcaacagca ttcaggatga attgcgccgg gctccattcg ggaagccgat 1086001 catttttcta gtcccggatc aaatgacgtt tttaatggaa tacgagcttg ctaaaacgcc 1086061 agatatgggc gggatgatac gcgctcaagt gttcagtttt tcacgattgg cctggcgcgt 1086121 cctccagcat acgggaggaa tgagcaggcc gtttctgacg agcaccggcg tacaaatgct 1086181 cctgcggaag ctcattgagg agcataaaca ggagttcaaa gtctatcaaa aagcgagtga 1086241 caaaagcggg tttaccgcac aggttgagcg gatgctgaca gagtttaagc gctattgtct 1086301 ggaaccggag gatatccgcc ggatggcgga aagcggaacg gcttccgagt atcgcggaga 1086361 acgtgtttta tctgaaaagc tccatgactt atcaattctg tatcagcaaa tggaaaaaag 1086421 cctcgcagat caatatcttc actctgagga ttatttgaca ttgctggcag agcatatccc 1086481 gcttgcggaa gatataaaag gcgcccatat ctatgtggat ggcttttatc agtttacccc 1086541 gcaggaattc agggtgttgg agcagcttat ggttcatgcg gagcatatca cgttttcgct 1086601 cacagcggac aagccgtcat atgagcggga gccgcatgaa ctggaattgt tcagaatgac 1086661 ggggaaaacc tattaccgcc tgcatcagaa ggcgaaggaa ctgaatttgg acattacgta 1086721 taaagagctg agcgggactg agcggcatac aaagacgccg gaattggcgc atctagaggc 1086781 acagtatgaa gcgcgtccgg ccattccata cgcagaaaaa caagaagccc ttactgtgat 1086841 gcaggccgca aacagacgag ctgagctgga aggcattgct cgggaaattc acgccctagt 1086901 cagagagaag ggatatcgct ataaggatgt agcaattctt gcgcgccagc cggaagacta 1086961 caaggatatg gtgaaggaag ttttcgcaga ttacgagatt ccttatttca ttgacggaaa 1087021 agcatctatg ctgaaccatc cgttaattga atttatccgg tcgagccttg atgttctgaa 1087081 agggaattgg cgttatgaag cggtgtttcg ctgcgtgaaa accgaactgc tattcccgct 1087141 caatgaaccg aaggccaaag tgagagaaca ggtcgatcag ctcgaaaatt actgtatcgc 1087201 ctatggtatt aaaggcgacc gctggacaaa gggcgatcgg ttccaataca ggcgttttgt 1087261 gtcattggat gatgattttg cgcagactga tcaggaaatc gaaatggaaa acatgttgaa 1087321 tgacacccgc gattggattg ttccgccgct ttttcagctt caaaaacgca tgaaaaaagc 1087381 gaagacggtt caagagaagg cggaggcgct ctatcgttat ttagaagaga cggatgtgcc 1087441 gctgaagctg gatcaggaaa ggcagcgtgc tgaggatgac ggcagaatca ttgaagcgca 1087501 gcagcatcag caggcgtggg acgcagtcat tcagctgctt gaggagtttg ttgaaatgat 1087561 gggagatgat gagatttctc ttgatttgtt tcagcaaatg atagaagccg gcgcggagtc 1087621 gcttacattt tctctaattc cgcctgcgct tgaccaggtg tttgtcggca atatggattt 1087681 gtccagaatg tatggcacct cctgcacctt tgtgctcggg gcaaacgacg gcgttctgcc 1087741 ggcacgccct gatgaaaacg gggtcctgtc ggatgatgac cgggaatggc tgaaaacgat 1087801 tggggttgag ctatcctcag gcggacgaga gcgtttgctt gatgagcact tcctcatcta 1087861 catggcgttt tcaagtccgt ctgaccggct ttacgtatcg tatccgattg ctgatgcgga 1087921 aggaaaaacg cttttgccgt cgatgatcgt taagcggctg gaagaactgt ttccgcatca 1087981 taaggagcgc ctgttaacaa atgaacctga acaggtcagc gatgaggaac agctgatgta 1088041 tgttgtgaat aaaagcgtgg cacagtcctt taccgcgagc cagctcaggt tatggactcg 1088101 ggaatacgac atcagcgacg tctggtggag cacgtacaat gtgctgatga gtgagcagga 1088161 caggctgcaa tcgaaaaagc tgttctcaag cctgtttttc cggaatgaag tgaagcagct 1088221 tgaacgcagc gtgtcgagac agctctatgg tgaacgtatt cagggcagtg tatcgagaat 1088281 ggaaaccttt aacgcatgcc cgttttccca ttttgcgtca cacgggctgc atttgaagga 1088341 acggcaattc ttcaagcttg aagcaccgga tatcggccag ctgtttcatt ccagcttaaa 1088401 gctgatttcg gacaggctgc gtgagcaaaa gctggattgg cgcgatttaa cgaaggagca 1088461 gtgcgagctg ttttcctatg atgcggtaga gcggctggca ccgaaactgc aaaaggaaat 1088521 tctgctcagc tcaaaccggc attattatgt gaaggaaaaa ctgcaaaaaa ttgtgacacg 1088581 tgtgtccggc attttaagcg agcatgcgaa agcgagcgga ttcgtaccga tcgggcttga 1088641 actgggcttt ggaggaaaag ggccgcttcc gccgctgacc tttcaactga aaaacggctg 1088701 tacgatggaa ctcgtcgggc gaattgaccg tgttgataag gctgaaagct caaaaggcct 1088761 gctcctcagg attgtcgatt ataaatcaag cgacaaaggc cttgacttag cggaagtata 1088821 ttacggattg gcactgcaaa tgctgacgta ccttgattta tcgattacac attcagctga 1088881 ctggctcggg atgagggcga cgcctgccgg agtgctgtat ttccatattc atgacccgat 1088941 gattcaatct aatctcccgc ttgggcttga cgagattgaa caggagatct ttaagaaatt 1089001 taaaatgaag ggcttgctcc tcggtgatca ggaagtggtt cgcctcatgg atacaaccct 1089061 tcaagaggga cgttcaaata tcataaacgc cggcttgaaa aaagacggct ctctcagatc 1089121 agactcagca gcagtcggtg aaaaggaatt tgatcttttg acaaagcatg tgcgccgcac 1089181 cttccaagaa gcgggcgaac aaatcaccga cgggcgcgta tccattgagc cgtacaaaat 1089241 gaagaacaag acgccgtgca catactgtgc gttcaaatca gtatgccaat ttgatgaatc 1089301 actggaagaa aacgagtatc gcccattaaa ggctgaaaag gacaagacaa tacttgagtg 1089361 gataaaaaag gaggcggatg gcaatgaaca ttcctaaacc ggcagacagc acatggacag 1089421 atgaccaatg gaatgccatt gtttcaaccg gccaggatat tcttgtggca gcggctgcgg 1089481 gctctggtaa aaccgctgtg ctcgttgaac gaatgattcg gaaaatcacc gcggaggaaa 1089541 acccaataga tgtagaccgt cttctcgttg tgacatttac aaacgcctca gcggcagaga 1089601 tgaagcaccg aatcgcagaa gccttggaaa aagagcttgt acagcgcccc ggctcgctgc 1089661 atattagacg ccagctgtct cttttaaacc gggccagcat ttcgacgctc cattcctttt 1089721 gcctgcaagt gctgaagaaa tattactact tgatcgatct tgatccgggc tttcggatag 1089781 ctgatcagac ggaaggcgag ctgatcgggg atgaagtgct tgacgagctg tttgaagacg 1089841 aatacgcaaa gggcgaaaag gcgttttttg agcttgttga ccgctatacg acagaccggc 1089901 atgatctgga tctgcaattt ctcgttaaac aggtgtacga gtattcccga tcccatccca 1089961 acccggaggc gtggctggaa agctttgttc atttgtatga tgtatcagaa aagagcgcca 1090021 tcgaggagct gccgttttat caatatgtca aagaagatat tgcaatggtg cttaacgggg 1090081 cgaaggaaaa gctcttgcgc gcgcttgagc tgacgaaagc gccgggcggc ccggcgccgc 1090141 gtgctgacaa ttttcttgat gatcttgctc agattgatga actgattcag catcaggacg 1090201 atttcagtga actatataag cgggtgcccg ccgtctcttt taagcgtgcc aaagcagtaa 1090261 aaggggatga gttcgatcca gcgctccttg atgaggcgac agatttgagg aacggcgcaa 1090321 aaaaactgct tgaaaagctc aaaaccgact acttcacgcg aagtcctgaa cagcacttga 1090381 aaagcctagc cgagatgaag cctgtcattg aaacgctcgt acagcttgtc atcagctatg 1090441 gaaaacgatt cgaagctgcg aaacaggaaa aatcaatcat cgatttttcg gatttggagc 1090501 attactgttt agcgattttg acagctgaga atgacaaagg tgaacgtgag ccgagcgagg 1090561 ctgcaaggtt ttatcaggaa cagtttcatg aggtgctcgt tgacgaatat caggatacca 1090621 acctcgtgca ggaatcgatt ctgcagctcg tcacaagcgg tccggaggag actggtaacc 1090681 tgtttatggt aggagatgtc aaacagtcga tttatcgatt caggcttgcg gagccgcttc 1090741 ttttcctctc taaatacaaa cggtttacag agagcggaga aggcacgggg cggaaaatcg 1090801 atttaaataa aaatttccga agccgggctg atattttaga cagcacaaac tttttattta 1090861 aacagctgat gggcggcaaa atcggtgagg tcgattatga cgagcaggct gagctgaagc 1090921 ttggtgcagc gtatccggac aatgacgaga cggaaacaga gctgctgctg atcgacaacg 1090981 cagaagatac ggatgcaagc gaggaagcag aagagcttga aacggtgcag tttgaggcaa 1091041 aagccatcgc taaggaaatt cgtaagctga tttcatcgcc gtttaaggtg tatgacggaa 1091101 aaaagaaaac acatcgcaat attcaatacc gagatatcgt gattttgctc cgttcgatgc 1091161 cgtgggctcc gcaaatcatg gaggagctga gagcacaggg cataccggtt tacgccaatt 1091221 taacgtcagg ctattttgaa gcggtcgaag tcgccgtcgc gctttctgtg ctgaaggtga 1091281 ttgataatcc gtatcaggat ataccgcttg cctctgtgct gcgctcaccg attgtcggag 1091341 cagatgaaaa cgagctgtct ttgatccggc ttgaaaataa aaaagcgccg tactatgagg 1091401 cgatgaaaga ctacctggct gctggtgacc ggagcgatga gctttatcaa aagttaaata 1091461 cgttttacgg acatctgcaa aaatggcgcg cgttttcgaa aaaccactca gtatctgagc 1091521 tgatttggga agtgtaccgc gacaccaaat atatggatta tgtcggcggc atgccgggcg 1091581 gaaaacagcg ccaggccaat ttgcgtgttc tttatgacag ggcgcgtcaa tatgaatcaa 1091641 cggcatttcg cggcttgttc cgtttcctgc ggtttatcga acgcatgcag gagcggggcg 1091701 atgatcttgg tacggcgaga gcgctcagcg agcaggagga tgttgtccgc ttaatgacga 1091761 tccacagcag caaagggctc gaatttccag tcgtgtttgt agcaggtctc ggccggaatt 1091821 tcaacatgat ggatttgaac aaatcgtacc tgctggataa ggagctcgga tttggcacga 1091881 agtatattca tccgcaatta cgcatcagct atccgacact tccgctcatt gcgatgaaga 1091941 aaaaaatgcg cagggagctg ctgtcagagg aattgcgtgt gctctatgtt gcattaacga 1092001 gagcgaagga aaagctgttt ctgattggct catgtaagga tcatcagaaa cagcttgcaa 1092061 aatggcaggc atccgcgtcc caaactgatt ggcttctgcc ggaatttgac cgctatcagg 1092121 cgagaacgta tctagatttc attgggccgg ctcttgccag gcacagagac ttgggggatt 1092181 tggctggtgt gccagcacac gctgacatct caggtcaccc ggctcgtttt gccgttcaaa 1092241 tgatccattc ctatgatttg cttgatgatg atctggaaga aagaatggaa gaaaaaagcg 1092301 agcgcctaga agcgatccgc cgaggtgaac cagttcccgg ctcgtttgcg tttgatgaaa 1092361 aagcccgcga gcagctgagc tggacctacc cgcatcaaga agtgacgcaa attcggacaa 1092421 agcaatcagt ttctgagatc aagagaaaaa gagagtacga ggatgaatac agcggcaggg 1092481 cccctgtaaa accggctgat ggaagcattc tgtacagacg tcccgctttt atgatgaaaa 1092541 aaggcctgac agcggcagag aaagggactg ccatgcatac ggttatgcag catatcccgc 1092601 tgtcacatgt gccgtcgata gaagaagctg agcagacggt tcacaggctt tatgaaaaag 1092661 agcttctcac tgaagaacaa aaagacgcta ttgatataga agaaatcgtg caatttttcc 1092721 atacagaaat cggcggacag ctgatcggtg ctaagtggaa ggaccgggaa ataccattca 1092781 gcttagcgct tccggccaag gagatctatc ctgatgcaca cgaggcagat gagccgcttt 1092841 tagtgcaggg tattattgac tgtctctatg aaactgagga cggattatat ctattggatt 1092901 ataagtcgga ccggattgag ggcaaattcc agcatggatt tgaaggagcg gccccgatct 1092961 tgaagaaacg atatgaaacg caaattcagc tgtacacgaa ggcagtggag caaattgcaa 1093021 aaacaaaggt aaagggatgt gcgctttatt tctttgacgg agggcacatt ctgacattat 1093081 agcgagatcc ataagctccg gaatttcagg cggagcgggt ctcgttttct atataaaaga 1093141 gaggtgaaag catttgcgga ttttacatac ggctgactgg catcttggaa aaacgcttga 1093201 aggaagaagc aggctgagtg aacaggccga tgtgctggat gaactgaata cgattgtaaa 1093261 ggatgagcag atcgatgcca ttgtaatggc gggggatgca tttgacaccg taaacccgcc 1093321 agctttagcc gagcagctgt tttatgaaag cctgtctgcg cttagcgaca gaggaaagcg 1093381 cccgatcgtc gtcattgccg gaaatcacga taatcctgac cgtttgtccg ccgcttcacc 1093441 gctgacacat gaaaacggca ttcatttaat cggttatccg acaacagagc cgattcatat 1093501 tgaagtgcct tcagcaggag agcttttggc ggttggagcg ctggcgtacc catctgaagc 1093561 gcggttaaat gaagtgctat ccgatacgtt tgatgaaaag ctgctccgtg atcactatga 1093621 tgtgaaaatc aggcaggcgt ttgagcatat gacaagccgg ttccggaccg atgcagtgaa 1093681 gattgccgcc agccatattt atgtggcagg cggaaaccaa accgattcag agcggccgat 1093741 tgaagtcggc ggtgcataca cggtggctgc tgaaagcctg ccggcagatg ccgcttacgt 1093801 tgcgctcggc catttgcatc gcccgcaaac gatcaagcgg gcgcggacgc ttgcgcgtta 1093861 ttcaggatct ccgctcgcct acagcttttc tgaagcgggc tacgctaaat cagtgacgat 1093921 tgtggacgca aagcctgggg aagaggccac ttggcaagag gtgttattat caagcggcaa 1093981 gccacttgtg aagtggaaag cggcaaatgg attaagtgag gtgtacagct ggctggatga 1094041 aggcagagat cagaatgctt ggattgactt ggaaatccgt gtcgcggacc agctgtcact 1094101 tgaagagatt cacaggctgc ggaaggcgca cccgggcttt atccatatca ggccggtttt 1094161 tgaagaacag aacaaagacc gggaacggat cgaggttaaa catgtctcaa tcgaggaccg 1094221 ctttaagaaa ttttatgaaa aacaaactgg cggtgcggtg ccggatgaag aaatggtgaa 1094281 gctgttttta gagcttgcat caggcgttga agaggaggat gcgaaatgaa gccgatcgcc 1094341 ttaagcatta aggggctcca cagctttaga gaggagcaga cgatagattt tgaaggcctt 1094401 tccggtgccg gtgttttcgg cattttcggc ccgacaggaa gcggtaaatc ctctatactc 1094461 gacgcaatga cgcttgcttt atacggaaag gtggaacggg cggcgaataa tacgcacgga 1094521 atcttaaatc acgccgaaga tacgctgtct gtgtccttta cctttgcgct tcagacgaat 1094581 caccaaatct catacaaagt cgagcgtgtg tttaagagaa cggatgaaat gaaggtaaaa 1094641 acggcacttt gccgcttcat cgaaatcaag gacgagcata cggtgctggc tgataaagcc 1094701 agcgaagtga ataaaagagt ggaggagctc ttagggctga cgatcgacga ttttacgaga 1094761 gcggtggtgc tgccccaagg gaaatttgct gaatttctgt ctttaaaagg ggcagagcgc 1094821 aggcatatgc ttcagcgttt atttaatttg gagcaatatg gagacaggct tgtgaaaaag 1094881 ctgagacggc aggcgcagga agccaatgcg agaaaaaatg aaatgcttgc tgaacagtcc 1094941 ggtctcggtg aggcgagctc agaggcagtg gagcaggctg aaaaggttct cgaacaagct 1095001 gaagcccggc tggaagcgat gaggaagaac cgtgatcagg cgaaggagcg gtttacagag 1095061 catcaggaga tatggaatgt ccaaaaggaa aaatccactt atgaagaaga ggaaaaacgt 1095121 ctcgcagaag aacagccgca tatagacagc atgcaaaaac gcctgctgga agcagaaaca 1095181 gcagcagccc ttaagcccta tgcggaccgg tacgcagaag cgatccagca tgaggagcaa 1095241 gctgaaaagg aacaaacgct agcccaaaag gatttagcag accggacagc tttctttcag 1095301 caaaaacatg aagagtatga agcgtggcgc cagcataaaa gcgagaaaga gcctgagctt 1095361 ttagccaaac aggaacagct ttcacgcttg caggaaatcg aaatcaaact gagtgaggcc 1095421 aagcaagagg aagagcgcaa aaaggctgac ctccggcaga aagaagaggc tcttcaatct 1095481 gtcatgaatg aattagagac cgtaacagac cgcctgacac gagggcaaaa cagacagaca 1095541 gaattgaagc agcagctcaa atccctgcag gtgacatccg atgagcgaaa aagctgccag 1095601 caggccgcag agatggcatt gcgcatcaga caaaccgagg aacaaatcaa aaaagagaaa 1095661 aaacgaagtg aagaattgaa cctcgtgctg cagaagatga atgaagagaa gaatacactc 1095721 gttcaaaaga cggaagcgga agaaaacaac atcattcagg catatgaggc agttcaaact 1095781 gtgtaccatt tggtgtgcga aacggaacgc tcattaacac gtatgacgga agaggctaga 1095841 aagagtcaac acacgcttca cttacagcgt gaaaaagcaa gggtggcact gctgacaaaa 1095901 gagttagccc aaaagctgac tgccggaaag ccttgcccgg tatgcggttc aaccgatcat 1095961 gatccatctg cctcggtaca tgaaacgtat gaagccgaca gccatcttga agaggacatc 1096021 aaacggacag atgtgttatt gacggaagct gcagctctca gccaggagat tctttcagcc 1096081 aaaattatgc ttgaagaaca gtccgcgcgc tttattgaac agtgtccgtt tttgcagaca 1096141 attcaagcac agaaccttga agcggcagct tccttcgaac atcagccggt gtatgaagca 1096201 tttgaaactg ccaaatttga atggaaacga atcaagcagg acattctttc tgttaagaca 1096261 cgaatggcac aaatgattgg cgcctatcag gagtctttaa aaaaggccga gcagcttaat 1096321 gaaaaaatcg gttttgaaaa aagagaagcc gaccgtattg aaagcatcat cagtgagctt 1096381 caatcctcaa tggacagcag tctgaacatg tttaaagaag catttcagaa tcaatctgtg 1096441 gacgaagcag aaaaatggca gcaagccatt gaagaaaagg accgggctgc agaagaatgt 1096501 gaaaaacgaa ttgagaagag tatcgcgttt cttgctgagc atgaagcaca aaaggaaaaa 1096561 ctgcgggaat cgggacaccg gcttgagcgg gaaaagctgg agcttcatta tgcggctgaa 1096621 cgcatcaaga gcgtgatagc tgattatgag cacgaactcg gagattatgc aaaaggagat 1096681 tcgattcaaa tcaaactccg ctctgtccag caggatctaa agctgttaaa ggaaaaagaa 1096741 caatctttat atgaagaact gcaaagcgcc caaatgaagc tcaaccaagc gaaaagccgc 1096801 gcttctgcaa gcgagctcac tcttcaagag gcgaagggca gattggaaaa agcaaaagct 1096861 gcttggcttg agcatacaaa aaacacctcc attacccgga ctgaggaggt tgaacaaagt 1096921 ctcatcccag ctgatgaact tgaaaagatg aaaaccggca tagaccagtt tatggataaa 1096981 ctgaagcaaa atgctgcaaa cttaaaacga gtagcagaga tacttgccgg cagagcatta 1097041 tcagagagcg aatggaacga aaccgttgca gcattacaag aagctgagga cgcatttggc 1097101 gctgctatag aggaaaaagg cgcggccgca aaagcactgg ctgtcattcg cgaccatcat 1097161 aaacggttta atgaaattga agctgaactg aaaaaatggc agatgcatat cgacaggctg 1097221 gacaagctgc aagctgtgtt taaaggcaat accttcgtcg aatttttagc tgaggagcag 1097281 cttgaaagcg ttgcgaggga cgcctcagca agactcagta tgctgacaag acagcgctat 1097341 gccatcgaag tagattctga gggcggcttc gtgatgcggg atgacgcgaa tggaggcgta 1097401 cgacgcccgg tttccagttt gtctggagga gagaccttcc tcacctcgct ttcacttgct 1097461 cttgcgctgt ctgcgcagat tcagcttcgg ggggaatacc cgctgcagtt ctttttctta 1097521 gatgaaggct tcggcacact ggatcaagat ctgcttgata cggttgtaac ggccttggaa 1097581 aaacttcagt cagacaacct ggctgtcggt gtcatcagcc atgtgcagga actgcgtgca 1097641 cggcttccga aaaagctgat cgtccatccg gctgaaccga gcggccgcgg tacgcgggta 1097701 tcacttgagt tgatgtaagg gaggagcgga tatggcaaag cagattgccg gaatatgtga 1097761 gctgtgcggc cggagcgatg tccagctgac agagcatcat cttacaccga aagaggaagg 1097821 cggaacgttt ttgccgacag cgatgctctg tattccttgt cataaacaga ttcatgcctt 1097881 atataccaat caagagctcg ctgtacgttt aaatggaatg gctgaactca gaagcgatcc 1097941 agagcttgcc cggtttgtca aatggatcag aaaacagccg cctgagaagc tgatcaaaac 1098001 taagaaatca aatgaacgaa aaaagaaaaa atgactaaaa agcagccctc tctttgcaga 1098061 gcggctgctt ttatccgttt ccaaccatat cctgatcgtt gacatcgggg tctatataat 1098121 ttgtcgcgtt gactgcatta tttaatagaa ggaaatctcc cgtgtttcct gctcccgaac 1098181 cgagcgcaga ttttgaagag cttttcggag aaaggtaaaa ggaatcacca aagtttacga 1098241 ctccgcccga tatggaattg atagctatag gcccgacaat tgctggcata aacgacaccc 1098301 tttatcgaag tctctgttta ttatatgttc ttggcgggcg attgtgagcg cggagactga 1098361 atctgtctga tatgtttgag tctcgcatca ccgcgaataa gcgaagctga tccggcatgt 1098421 aaaacagaag aggctgagac cccttgaatt ttgatgctgc gaacataaat agccggcacc 1098481 tcgtggcaaa acgcgctttg tacacctgtt tcggggagcg gcttcacggc ctgctgctga 1098541 aagatctgat actccttttt gttaaatgag ccttcattat ggtaaaacgt ggacagagaa 1098601 cgctgcacag caaatacttt tacactcata tcgatttcat ttgtgtcgcc aacttgaaac 1098661 acacttgcga tcccgagaga attaaactta actagtctga tgcgcgatat gcgtttaagc 1098721 attattctgg cgcaagcgga gcaaacggcc caataataag agattcaggc ggtgtatcaa 1098781 aaatagaaga caggtagatg gattcagtgt ctccgatgtg gaaaacggag gaactggaca 1098841 caccgttcat ccgaatatcc ccgacttcca agctgcggtt gatgactgta aagatcatgc 1098901 ttgctcatct cctttcattt ctgatggaat atgctccaga aagtgttcta cagcgcggat 1098961 gacatcacgc ttcacatgct cagcgatatg ttctgcatat tgtgcaggcg gtgtattttc 1099021 ttcttttttg atatgggaca tataatagtg aatcctgctg tccatttgtt ttctgatgtc 1099081 ttcaataaca tgatgtctgt ttgtatcgtc aagtctgctg tcatattgat tttcaagctg 1099141 ttccaaaata tctgggattt cctcggttaa gtacatgtcg acattctggc ggatctgctg 1099201 catgagctga gcgctctctt cctgctgcat catcccgatt tgcggtgtcg actggctgac 1099261 gtcaaagttt tggacgctgt tcgggtcagt cggatttaaa ccgatattca aagtcccgtc 1099321 gagcctttcg attttcagct gatcaaattt atactccaca cgctcaatgg tagtggccgg 1099381 ccgctgtttc atcgtattca tttcagtttg aatctctttc agctgacgtt cgagctgctg 1099441 aatgtgaatc gcctgctgct gaacgaagga attcaagttt tgcaggtaag aggaaacaga 1099501 ttgatcatac atgttcttca cctctttcat atgattaacg gccaggaggc tggagcggga 1099561 ccaatgaacc tgtgtcgggc tcctgcagct ggagcggttg ccctgagcca gaaacttctg 1099621 gtgccggctc tacatagctt cctgtattat acaaatttga cagtgacttg attgatccgg 1099681 cgctcccgat ttgcagaatg gaggagttgc tgattgattc cagccggaga tagttgattt 1099741 gaatggtttg attaatatag aagttcatga gcctcactcc ttttacgcat tggccacgat 1099801 cggctgatca accgcatcat tgtcatacac attcgtcgcg ttttgataat tcatcacctt 1099861 gaggctgtcg ccggtattaa agctgccagc accggcaaac gttctgacct gagcctgagg 1099921 agaaatcgta atgcagtccc cgatgtgaac gactccgctc gtaccaatcg cattaatttt 1099981 aaacgctccg acaatggccg gcatacgagc acatcctttg ttgaaaaatt aaaaaaagac 1100041 aggtaaagtg aaatgacaat tccgatttca attgggctat tcacgatagc ttatgacaaa 1100101 cgcacatatg tgtgagagaa attttaaggg gacatatcgg ctctttgtga aagcgtttta 1100161 ttttttcggg ccgttatgtt taaacatggc aaaagaggat gttgggtata aattgagcgg 1100221 aaatgcggcg aaggatgccg ctatccgcct atggtgattt ttgtttattt ctttggtgtt 1100281 tttgcgtgta gaatgctttt tggagtatgt cgtgctgcgg tattcgattt ttgggcgggc 1100341 acattctcgc cctgaggtat atctcagaag tgctgagcaa aaatcggagt taaatgtggt 1100401 gtattctaat tgttatagaa aatgatttac atacgggagt tttcaagata tctcccaaaa 1100461 atcatttctt ctttaatccg ggtattcagc aggatatcca gctcttggct gcattgaatc 1100521 gtttcttttg aattcatgcc gtatttttgt gcggtttcaa ttagtgtgat cctcatttct 1100581 tcaattttac tgttcattac gctatctcca attctagatt ttattttgat ataaatacag 1100641 gatatcgtta gtataaccta ttttggctca aaaggttgcc tttcgtcaat ttgactaaaa 1100701 aagcgacaat ttttgctgcg gcctttttta atggagaaag gactaaagtc ttgctaagtg 1100761 tgcttgcaaa aagtcctgcc gttcctcaat ttctctaagt atgttggtct gctccttttc 1100821 gatttgaaag gggctttttt tgataaaagg atcatcagca gcactttgac aaatgtcaag 1100881 gtgccattcg ttgatgagag gagataatcg ttcaatagta aacgaccgct tcagcacgtt 1100941 tttcattaag gtgtgatatt gcgacctgaa ggcgggaatg gatagaagcc ttgacgaaag 1101001 cgtctttcct tttgtcagaa gcgggtcttc ttcataccat tcttgtacgg caagcgatct 1101061 tgtctccatc ggggaaacgt aaagccgacc ggattcgttt aaacaaaatg tgtagtaaaa 1101121 gccttgattg gtgcaggtgt tgccgatcag ccacaaaaaa aacagcttga catccagata 1101181 caatttaatc ctttcagcca attcgtcatc tccggctgtg cggatcagta tgaaaaattc 1101241 atgtaagaat gccgaggaat cattgttaaa aagggacaat ggaacccttg gatcggccgt 1101301 cttcactccg taactccttt taccggctgg ctgatggttc ttgatgttca aataaatgcc 1101361 ttcaggctgg ccattgatgg tcagaaagct gtacgaggca acgggagcag gtacgccgat 1101421 ctggtcaaaa aaacaatagg cgagtctgcg ccgcatcagg gacggatcat cctgttctgc 1101481 attcaaaaaa agtgtccttt caccaagcag agacttttcc cagctgattt cataggatgc 1101541 cttttccgct ctgtcacgct gtgtgagaag aatgggagaa acagatcgat ctgttacgaa 1101601 aagccccttg gctgtacctt tccttttcag ctgctcccga tgaaaaaata aatgcacgcg 1101661 ctccatattc tttcctcctt ctcaaaacga catttgtatg atatgtagag caagcccgtc 1101721 ctgaaacgaa atgaaaacgg aattgagaaa aagggatttc agcattcgac agagaataca 1101781 tgaaggagca ttctgattta aaagatgatg gaggaataac atgaaatttg cgacagggga 1101841 actttacaac cgaatgtttg tcggcctgat cattgacgat gagaaaatta tggatttgca 1101901 gaaggctgaa aaaaaactgt ttgaacttga gacgattccg ggatcgctga ttgaatgtat 1101961 cgcagaaggg gataaattcg ttgcgcatgc aaggcagctg gccgagtggg caaagaaacc 1102021 gaatgatgag ctgggatcat ttatgtattc attatctgag gtgaagctcc atgcacccat 1102081 tccgaagcca tcaaaaaata tcatctgcat cggcaaaaac taccgggatc acgcgattga 1102141 aatggggagc gaggctgata ttccggagca tccgatggta tttacaaaat cgccggtaac 1102201 ggttacgggg catggtgata tcgtaaagag ccatgaagag gttacctctc agcttgatta 1102261 tgagggagaa cttgctgtcg tgatcggaaa aagcgggact cgcatttcaa aagaagatgc 1102321 atatgaccat gttttcggat atacgattgt gaatgatatc acggcgcgtg atctgcaaaa 1102381 aaggcataag cagtttttta tcggaaaaag cttggatacg acatgtccga tggggcccgt 1102441 gcttgtacat aaatcatcta ttcaggagcc agagcgcctc aaggttgaaa caagagtcaa 1102501 cggcgagctg cgccaatccg gttcggcaag cgatatgatc ttttccattc cggaattaat 1102561 tgaaaccctc tcaaagggga tgacgcttga agcgggcgac attattgcca ccggtacgcc 1102621 gtctggtgtc ggcaaggggt ttacgcctcc aaaattcttg cggtcaggtg acaaaattga 1102681 tattacaatt gatccgatcg gaacgctgtc aaaccaaatt ggctgaataa aactggaggg 1102741 cggacccgga cccgcccgtt ttttctgata atcatctttg tgacagagga caagttcatg 1102801 gtactataag tggggtaatt tatctgatag ggggaacata tatgacacac ctacatatta 1102861 cgacatgggt ggtagcgctg attctgcttt tcgtcagcta ctcgctgtat tcgtcaggaa 1102921 gtgcaaaggg cgcaaaaatc actcatatga ttctgcggtt attctatatc cttattattt 1102981 tgacaggagc tgagctgttt gtccgtttcg ccaactggaa cggagaatac gccggcaaaa 1103041 tgattctggg cattatcacc atcggcctga tggaaatgct cctcatccgc aagaaaaaag 1103101 aaaaatcaac aggaggcctg tgggtcggct tcgtcattgt ccttttgctg acagtgctgc 1103161 tcggtctgca tttgccaatt ggttttcaat tgttttaata gaaaaaccta tgaacccggc 1103221 tctttgatag agctggtttt ttttatattt atcccctcat attccaaatc atttaaaata 1103281 accttaaaat tccctgtaag cggtatctcg tcctatgaaa ttatgatacc ttcaaggaga 1103341 ttcattattt tgcaggaggg ataacatgaa acgcagaaaa ttcagctcgg ttgtggcggc 1103401 agtgcttatt tttgcactga ttttcagcct tttttctccg ggaaccaaag ctgcagcggc 1103461 cggcgcgatc gatcaggcgg ctgctctgga aaacggcaaa gagcagacag gcgccatgaa 1103521 ggagccggaa caggtgaaat ggtacaaagt gaccccggga gcaacggata ttcagaaaaa 1103581 ctcacatatg gcactgaccg taaagagtga ttcagtactg aatgtatctg tatatccaag 1103641 taaggaaaaa gcgcttaaag atgagacgtt tgagatgtac cgttctttca cagcggagga 1103701 tggaaaaagc gaagtcattt ttccatacgc gtggagcggc ccttactatg taaaagttga 1103761 atacctcgga gaagaagaac cagaggacgg cggaacggca gaagcagctg cagaagccaa 1103821 gtatacgatt gggtataaag gcaccaaaaa acagccgtca gatttagaag aggaagaagc 1103881 ttgtccggtt gaaatgagtg tcgatcagaa gaaatcagga aaaggcatcc tggataagtt 1103941 gagatcgatt cgtgatgagc agctgagcca aacagcagaa ggcaaagaac tgacaagcct 1104001 ttattacaaa gcagcaccgt ttatcgttgc aaagctcgca ctcaataaaa cagcaagaaa 1104061 tgaaatctat caggatcttg tgacattaaa gccgttattt gacgatgtgt cagaaaacgg 1104121 agcatcatct tcgtataagg tcactgaaaa ggatcaaaaa gcgatcaacc ggctatatga 1104181 taaagcttta caatcagtcc cgtcattcct taaagaggag ataaagaaac aagcggaccg 1104241 actaaatatg aagcagctgc aaggcaaaac agcaggagcc attttaacag aaaacaatat 1104301 tgcagcaaaa agtgaagttc agacaacaaa ggttattttc aaggtgaagg acaataaaag 1104361 cctctcatcc gtacataatg aaatgaaggg cttttctgca agcgcgcaat cgaaaaaaga 1104421 catatctaat gtgaaaaagg caaagaaact gtttgacaat ctgtattcat ttgaacttcc 1104481 gaaagacgag aaacagaacg gcgcatatac ggcaagcgcc aaaagggtca aaagcgctgc 1104541 tgcgacacta tccaagatgt ccaatgtaga gtttgcggaa cccgtacagg aatacaaaag 1104601 cttggcaaac gatattcagt acccttatca atggccgctt aaaaacaacg gtgaaaacgg 1104661 cggtgtcaaa aatgcggatg tgaaatatga gcctgccaac acattgctgt ccaaacgcaa 1104721 gcttaacgat acactcattg cagtagtaga cacaggcgta gacagcacgc ttgccgattt 1104781 aaaaggaaaa gtaagaacag atctcggaca caattttgtc ggacgaaata acaatgcaat 1104841 ggatgatcag gggcatggga cgcatgtcgc aggcattatt gcagcccaaa gcgataacgg 1104901 ctattcaatg actggattga atgccaaagc aaaaatcatc cctgtaaaag tgcttgattc 1104961 cgcaggttcc ggagatactg aacaaattgc tctcggcatc aaatatgctg ctgacaaagg 1105021 agcaaaggtg attaatttaa gtttaggcgg aggctacagc cgcgtgcttg aatttgcttt 1105081 gaagtacgca gctgacaaaa atgtcttgat tgccgcagcc agcgggaatg atggagaaaa 1105141 tgccttatct tatcctgcat cttctaaata tgtgatgtca gtcggcgcaa cgaatcgcat 1105201 ggatatgacc gctgatttct ctaactatgg aaaaggtctg gacatctctg ctccagggtc 1105261 tgatatcccg agcttagtgc cgaacggaaa tgtcacgtac atgagcggaa cgtctatggc 1105321 gacgccatat gctgccgccg ctgcgggact gctgtttgct caaaatccta agctaaaaag 1105381 aacagaagtt gaggatatgt tgaaaaagac ggcagatgat atttcctttg aaagtgtcga 1105441 tggcggagaa gaagagttgt atgacgatta tggcgatccg attgaaattc cgaagacacc 1105501 tggtgtagac tggcattcag gctacgggcg gctgaatgtc atgaaggctg tcagcgcagc 1105561 tgatttacag cttaaggtca acaagctgga aagcactcaa acagctgtca gaggaagcgc 1105621 gaaggaaggc acccttatcg aggtgatgaa cggcaaaaag aaactcggca gcgccaaagc 1105681 cggaaaagac aatgcgttca aggtgaatat cgcgactcaa aaacaggatc aagtactgta 1105741 tctgaaagca acaaaaggcg atgcgaaaac atcgtataaa gttgttgtcg tcaaaggaaa 1105801 accttccggc acaccgaaag taaacgcggt gaaaacgaag gatacggcag taaaagggaa 1105861 ggcaaacagc aaagcgatga tcagagtgaa aaacaaatca aagaaagtca ttgcttctgc 1105921 caaagctgac gcaaaaggaa cgttttcggt gaaaatcaaa aaacaaaaag ccggaacggt 1105981 gctgtacgtc acggctgtgg atacagataa aaaagaaagc aaggaagcaa aagttgttgt 1106041 tgaaaagtaa ccaaaaagcg gtgctcgatg caccgctttt ttatttgcgc ccccgttgga 1106101 ctgctgtgta cataatggat cgctttccgt ttgaagccgt ccattcaaaa cggtctcctg 1106161 tcccttcgct gctgtagttg tagtgatgct gcatcgcgca ttgtgcggtg tcatttgaaa 1106221 agtgataaaa ggacacaccc tgccccgccg aagtattcga aaagactcct ttattataag 1106281 aaaagacgca atcgaatacc gataagccga agctgtgcaa gtgctgcaga aatgcgagaa 1106341 aggtttcgtc gtcaagcgaa tccaaaagcg ccatgagcgg ccgcttgact gatttctcat 1106401 agcggatgcg ttctccgccg gaaagggaga tgttttctgc accgcatgcc aaaaccaact 1106461 tgtcctgaaa gccggcttgc tcccactttc ctttatgatg gatccagatt gggctgtgtt 1106521 ggagactgtc cgccagcagt atatcgcctt caccgttttc gattaagcag atgccgtctt 1106581 caatgaggat ggtgccgtat tcccactttc gttcctctgt atataacaat tgtttccgtt 1106641 tcatccatgc tgtctccttt ttcttcattc ctctcttttc tttccaattc aagcctgtcc 1106701 catacaactc ttttatggac aaatcaacta tctgcctata gatgcataaa cttactaagg 1106761 tgctgaaaga aacgaaattg ttacgaaaga aacgggattg gagctgatgt cacatgtgtg 1106821 gaattacggg ttgggtcgat tttaaaaagc agctcgtcca ggaaaaacaa acgatggaca 1106881 gaatgacaga cactctttcc aaacgagggc ctgatgattc aaacgtttgg ggggagcacc 1106941 atgttttatt cggacataaa agacttgcgg ttgttgatat tgaaggcgga cgccagccga 1107001 tggcgtgtac ctataaaggc gatacgtaca ccattattta caatggcgag ctttataaca 1107061 cggaagattt gcgcaaagaa ttgcgggcgc ggggccatca attcgagcgt acgtcagata 1107121 ccgaggtgct tctgcacagc tacatcgagt ggcaggaaga ctgtgtcgac catctcaatg 1107181 gcatattcgc tttcgctgtg tgggatgaaa agcgtaatct gttgtttgcc gcgagagacc 1107241 gtctcggtgt aaagccgttt ttttacacga aggaaggctc ttcatttctc ttcgggtcgg 1107301 aaatcaaagc aatcctcgcg caccctgata taaaagcgcg agtggacaga acgggacttt 1107361 ctgaaatttt cggtcttgga ccgtccagaa ccccgggcac tggcatattt aaaggcataa 1107421 aagaaatccg cccggctcac gcgctgacat tttccaaaga cggacttaat atttggcgtt 1107481 attggaatgt tgaaagcgaa aaacatacgg acagttttga tgacacggtt gccaatgtca 1107541 gatcgttatt tcaggacgcg gtgacgcggc agcttgtgtc ggatgtgcct gtttgcacat 1107601 tcctatcagg cggtctggac tcaagcgcga ttacagcgat tgcggcgggc cattttgaaa 1107661 aggaaggaaa agcaccgctt catacttatt cgattgatta cgaagagaac gataaatatt 1107721 ttcaagcaag cgcttttcag ccgaatgatg acggaccatg gattgaaaaa atgacagagg 1107781 ctttcggcac aacgcaccac aaatgcgtca tcagccaaaa agacctcgtt gatcatttgg 1107841 aggaagctgt actggtcaaa gacttgccgg gaatggcaga tgtcgactca tccctgctgt 1107901 ggttttgccg ggaaatcaaa aaggactttg tcgtcagcct atcgggagaa tgcgcggatg 1107961 agattttcgg cgggtacccg tggttccata cggcagatgt tgagtctggc tttccatgga 1108021 tgagatcaac ggaggagcgg atcaagctgc tttctgactc atggcagaaa aaattgaatc 1108081 tgaaagaata cgtaaatgcc aaatatgaag aaaccttggc agaaacgcca ttattagacg 1108141 gagaaacggg tgtggataaa gcaagaagac agctgttcta tttaaatatg ctttggttta 1108201 tgacgaacct tttggatcgg aaggatcgca tgagcatggg ggcgagcctg gaagtgcggg 1108261 tgccgttcgc cgatcaccgg cttgtggaat atgtttggaa tattccgtgg gaaatgaaaa 1108321 tgcatgataa tcgggaaaaa ggcattttgc gcaaagcgct tgagggcatt ttgcctgatg 1108381 acattttgta tcgcaaaaaa agcccatatc cgaaaacaca tcatccggaa tatacaaaag 1108441 gcgtcagcga gtggctgaaa acgatcagaa gccaaaagga ctccgtgctc cataccttac 1108501 tggacagaaa acaattagat cagcttttag aaacggaagg ctcctccttc aaggtcccgt 1108561 ggttcgggca gctcatgaag gggcctcagc tgatcgccca tcttgctcaa attcatacat 1108621 ggtttgaagc gtatcgcatt gatattgacg agaggtaggt tcaatacaaa tgtgattaaa 1108681 agccagagat gtatagattt aaataagaag gatagatgag cagggaaata tatgctctat 1108741 ctatcctttt ttgtacaaca gcactatcga attgcccccg cattccttca ataagaatga 1108801 ataggtttta atgttctgcc gataaaacta gctgataccg ggcttaactt taattcccta 1108861 gcccatacag aaagttgacc aatatggtga atttcgtgag cgatgatatg gtgtaatatt 1108921 tcatctcgcg tatataaaac acctgtctcc caaggaacgc ttacaagttc atcttttatt 1108981 tgatctgaat gtgtttgtaa aacatcaatt atttcagttc ggaatgtatt tgagagagat 1109041 ttcactttat tgagtgtttg ataatcagcg aactgaacag cgatatcttc ttttccttgg 1109101 atagcacgaa tccaactata ttccacatca ataatatgaa aaagggtata taaaatattc 1109161 tctactccgc caagacgatt tttaagtaat tcttcagtgg ttagttgatg acaccaagta 1109221 aaccattgat ctctaacctg ccagttatat tcaaaaaatt tcatcactaa actcactcca 1109281 atactatcat gtatcataac aattagccct tttttccgtg attcctctat taatgaagtg 1109341 atgattgaga aatgtttaca ttctacctgt tgtatggcat taaaaataat aatgcatatc 1109401 tcgtcgatga tgctgtgcgt cttgttactt ttacaaagta agaatcggca ttttcttcat 1109461 atacaattag gaaaaaacat actagacttg aagaagcagt gatacatagg agtgagaaaa 1109521 tgaaagagat aaaagaagct taccagcaat gcggacagat tgttggcgaa tacgcgccag 1109581 cctgtttcaa agcattatca tatctcccgc taaagcaaag acaagcctct tgggcagtat 1109641 tgtcgttttg ccacacggcg gccagtgcag acgaaaaggt attgcccgca tttgaagcta 1109701 aagctgatca tgtttaccaa aggacaaata acggtaaaca acatctatgg aaggcttttg 1109761 atcatgcgta tcggaccttt acattggaaa gcgaaccttt tcgggagttt attgccgcac 1109821 aaaaagaaga cgccaagccg tatgatgacc ttgatgaact gctcatgtac gcatatcgga 1109881 cgggcggtgc tgccggattg atgctgctgc cgatactgac acgccgaaaa caagatcagc 1109941 tcaaacaagc agccgtctct ctcggcttgg ccatacagct ggttcgcttc ttaagtgatc 1110001 ttggcacaga tcagcaaaaa aaccgcattc cccgtcaggt aatgcagcaa ttcggctata 1110061 cagaggctga tctccaaaaa ggcaccgtaa ataaagcgtt cacaatgacg tgggagtata 1110121 tcgcttttga agcagaagcc taccttgaag agtgtcagga tgccttgccg ctatttccgc 1110181 agtattctca aaaaacggtg aaagccgctc ttcatttgca ccgggctgtt ttagaaaaaa 1110241 tccgggcgaa gcagcacgat gtatttcaat atcacttcgc tctcacagag accgaagtga 1110301 agcagattct gtctgatatc taaaaaacac ccggccttga ttgagccggg tgttacgcca 1110361 tacctttttg aatccagata cgtgagcgcc atcttctgta cattaagatt ccccggaccc 1110421 attcatccgc gataaaagaa atccaaatgc cggcaagacc gaaaccgagg tggatgccga 1110481 aaagataagc aagcgggagg ccaatgcccc acattgaaat cattgccatg taaaccggga 1110541 atttcgcatc ccccgcggcc cgcagagagt taatgataat gacattaaac gagcggcctg 1110601 gttcaaggat aatggtcatg gcaatcaata ggcttgcagt tgctataatg tcagggcttt 1110661 gtgtgaagag tccgatcagg tcttttgaaa agatcgtcat caaaacagag gtagccgcag 1110721 caattccgag tgcccaatat aagctcttca tgcagcgctc ataagcggca tcaaattgtt 1110781 tgccgccgat ataacggccg attaagattt gtgtaccctg gctgatcgca gtgccgaaca 1110841 gcaaaataaa catcgtaata ttttgcgtat acacttttgt tgtcaacgcc tgcgcgccca 1110901 tgatggcgat aaaatacgtg actatcattt gcgacaggtt gtatgaaagc tgctctcccg 1110961 cagaaggaat gccgattttc agcagcttgc gcaaatgctc tttatgcata tgaaagactt 1111021 ttttcagcga catcttcagc tggatgcgtt tgttgacaat cacaatcatc gcgattaatc 1111081 cgatgacgcg ggcgatagat gtggacatgg ccacaccggc aacaccgaga acaggaaagc 1111141 cgaacaaacc gaaaatcaca acaaagtttc cggcaatgtt taaaatgttc atgccgatag 1111201 tgacaaacat tgtatctttt gtgtagccgt agctttttaa gatcgcgctg aatgtcatga 1111261 ttaaagcctg aataaaggac agacctccga caacttgtaa aaagactttc gcatcaggca 1111321 tcagtgcgtc tgataatccc atcatatgaa gcagagggac agccgcgaaa aagacgacgg 1111381 cgctgatggc caggctgatg aagaagttgg cgccgattga cacataagcg acttccatgg 1111441 cttctttctt ttgccgtgag cctagaaatt gtgaaatgat aacggtcgtt cctgttgcga 1111501 taaagctgaa catcacgata attaaattta aaatctggtt gctgacgccg actgctgcca 1111561 cgctgttatc cgagtattgg ctgagcatca gtgtatcggc attacccata aacatatata 1111621 atgagacctc aataaagatc ggccaagtaa gcgaaaataa tgagaacgtt ttgtcagcgg 1111681 gttttttcaa agcagttgat ttgaagacag cttgtttcat cgtgtctaac ccctttcgta 1111741 aataaaatca acgttttaaa gtgtacctcc atttccttat aataaaaagg gatagaaacg 1111801 atacttcttg taaaaatccg acttaaaaag gaggatgatt caaatgcctc gcatcctgtt 1111861 tacagtcccg ccttttccgg tatttatcgc agctggggaa ggggttttta aaaaaggaga 1111921 aacccatgtg aaacgtgtat tctccgtgtt tgatctgata tatgtcaaac agggaacgtt 1111981 atatataacg gaaaatgaaa catcgttttc tgttgaaggc ggcgagtaca tcttgctttc 1112041 tcccggtctt gaacactacg ggacgaaggg cagtgatgaa gcaacctcct actattggct 1112101 tcacttcgat gaacatcgat atgaatttac ggcaaaggga ggcagcaact ggtctgagct 1112161 tcagcaggaa aaagggagct tcgaagagct ggcccgctac ggattggcct tgccgagaaa 1112221 aggcaaggtg cagcgcccgc agtttatggc gcagcagttt gaaaagctga tcgattactc 1112281 cgcggaaaac tctgatttgc cgctcagaaa gcaaatttta tttgaggagc tgatgctgca 1112341 tcttcaaaaa gaagcgttcc aaataccgtc tgcgaaagag cgggtagcct gggaggcggc 1112401 ccggtattta caggagcact ataaggaaaa gacgacaatc aaggatctgt cgctcgccct 1112461 tcactatcat caggattatg tgagccgctg catgcagcag gtgctcggcg taactccggc 1112521 acaatacacg aaccgggtga gaatgacgga agcgaagcgt cttttatcct ctacaaatga 1112581 taaaatgggc gttattgcgg aaacggtcgg aatggaagat ccgacatact tttcaaaact 1112641 ctttaagcag atagaaggca tttcaccaat tgaataccgg aaaattgtca gccggaaagt 1112701 tcaataacca gacgagggat gaacatgaaa acaacaattt acgatgtggc aaaggcggcg 1112761 ggtgtttcga tcacaactgt gtcccgtgtg ataaacaata cggggagaat cagcgataaa 1112821 acacggcaga aggtcatgaa tgtcatgaat gaaatggcat acacgcccaa tgtccacgcc 1112881 gcggcgttaa cgggaaaacg aacgaatatg atcgctctcg tggcgcctga tatttcaaat 1112941 ccgttttacg gcgaactggc caaaagcatt gaggaaagag cggatgagct cggttttcaa 1113001 atgttgattt gcagcaccga ttacgatccg aaaaaagaaa caaagtattt ttctgtgctg 1113061 aaacagaaaa aggtggatgg cattattttt gcaacaggga ttgaaagcca tgacagtatg 1113121 tctgctttgg aggaaatcgc cagtgaacaa attccgattg ccatgatttc tcaggataag 1113181 ccgcttcttc cgatggatat tgttgtgata gacgacgttc gtggcggata tgaggctgcc 1113241 aagcatcttc tgtcactcgg ccacacgaac atcgcctgca ttatcggaga cgggtcaacg 1113301 acaggcgaaa aaaatagaat caaaggcttc cgtcaggcga tggaggaagc gggcgtgccc 1113361 attgatgaat cacttatcat ccagacgcgg ttttccttgg aaagcggcaa ggaagaagcg 1113421 ggaaaattgc tcgacagaaa tgctccgact gctatttttg ccttcaacga cgtattggct 1113481 tgtgccgcca tacaagctgc gagaataaga ggcataaaag tgccggatga tctttctatc 1113541 attggttttg ataatacgat actcgcagaa atggcggctc cgcccctgac aaccgtagcc 1113601 cagccgataa aagagatggg gcggagcgtc atcgaactgc tggcagaagc aatagaggga 1113661 aaacgaaagg cgaaacaaaa aatagtgctc ccgcctgagc ttgtagtcag acattctaca 1113721 tcaccgctca acacatgagc ccgctaatga gcgggttttt tcattatgac agttgaagcc 1113781 aaaaaaacat attgcgtgta aaccaaaggc ggtgtaaaat ataaccatct tttgagaaag 1113841 cgcttgcgca aaatggcaga gcggatagaa ccgctgtttt tttagctgtt aagagaaaac 1113901 gctttctcaa agcgagcccg aaatgagata aaggagagga tgggacgtgg aacatcaagt 1113961 aagatgtgca gtattgggat taggaaggct cggttattat catgcgaaaa atctcgtcac 1114021 cagtgtgccg ggggcaaagc tggtttgtgt cggtgatccg ttaaaaggga gagcggagca 1114081 ggttgccaga gaactcggta tcgaaaaatg gtcagaggac ccgtatgaag tgttagaaga 1114141 tcccggcatt gatgctgtca ttatcgtaac gccgacaagc acacatggtg atatgatcat 1114201 caaagcagcc gagaacggca aacagatctt tgttgaaaaa ccgctgacat taagccttga 1114261 ggaatcaaaa gcagcttctg aaaaagttaa ggagacaggt gtcatctgcc aagtcggctt 1114321 tatgagacgg ttcgatcccg catacgcaga tgccaaacgg cggatcgacg ctggagaaat 1114381 cggcaaacct atctattata aaggctttac gcgcgaccaa ggcgcgcctc ccgcagaatt 1114441 tatcaaacac agcggtggaa tttttatcga ctgttccatc catgactatg atattgcccg 1114501 ttatttgcta ggggcggaaa tcacttctgt ttcaggacac ggcaggattc tgaacaatcc 1114561 gtttatggag cagtatggcg atgtggatca ggcgctgacg tatattgaat ttgactcggg 1114621 cgcagcgggg gacgtcgagg caagcagaac ctctccatac ggacatgaca tccgggcgga 1114681 ggtgatcggg acagagggca gtattttcat agggacattg agacatcaac atgtgaccat 1114741 cctatcggct aaagggagca gttttgatat cattccagac tttcaaactc gttttcatga 1114801 agcctactgc ttggagcttc agcatttcgc cgagtgtgtc cggaatggaa aaacaccgat 1114861 tgtgactgat attgatgcga cgatcaattt agaagtgggt atcgccgcaa ccaattcctt 1114921 tcgaaacggc atgccggtac agctagatgt gaagcgcgct tatacaggta tgtaaaagct 1114981 aagtatgttg catttgaggc tttccgcaaa aaaagcaagg gcattttagc ccttgctttc 1115041 tcttttctca tataaatagt acatataatc agtaggtacg cctgaatggt ccagctgtct 1115101 cagcatggcg gttacgttcc ctctgtggta agtgccgtga ttgacgacat gcaggatggt 1115161 gtctgcatag gttgattcca gtgtacctag tttcggatgc tgcattgtga aggtctgttc 1115221 taagtccgtc tggcggctga agaaatcatg atactgtgac tccagctcgg cagcgtgctg 1115281 tttaatcgct gccatattac cttgcgcgga ctgtaatttg cctgcgctgt ctataatctc 1115341 ttggtaggcc actcccgaaa gaacattcag ccaaatgtag tcagccctgc acatatgaag 1115401 cagcacgtcg ctgacagaag gaaatacgct ctttacttct tgataggcag tttcctccgg 1115461 caggttttcg atatgggtaa atattttctt gtttgcccaa gaatgatagt cataaaactg 1115521 ttttgcatca gtcatcagca tgcccccttt tctaagaaat tcgttttttt catctgtttc 1115581 tccttcaatt gcaaaagagt gacaccccaa aatatcctgc cgctgcccac attaccgctg 1115641 cagagcattt gtttacgatc agcataagcc tgccgctcgt atctatcgtc tgaaacaacc 1115701 ggcccgctat tgcaaggctg atgaaccaaa tccaagacac agcgatgcag gcggccataa 1115761 agagccattt ctcaagcccc gaatattgaa gagagctcgt gccgatgacg ccgatcgtgt 1115821 ccagaatggc atgcgggttt aaaagagaaa cagcggccgc aaacgcagct tgcttttttg 1115881 gtgtgaacgt atgtttctca ttttggcttg tgttcggacg gatgttccaa gtcacccagc 1115941 ccatataaag caaaaataaa aatccgccgg ccatcatgac tgtctcaaac acaggcagct 1116001 cctgcacaat gacagacacg cccgcaacgg ctaatacaat taacaaggta tcgcagactg 1116061 aagcactgat gacagctggg agagcccgcc aaatatgctt ttgcaacgcg ccttgctgaa 1116121 aaataaacac attctgcact cccagcggca aaattaagcc aaacgcgagc acaattccgt 1116181 gaatgattgc attcatgctg aaaaagctcc tttcacattt tttttcaatc ataagagaga 1116241 ttgtcactaa agtctccagc catttggttg ggttaggaac cagccaaatg tataatgtgt 1116301 aaaaaagggg ggcatgacct tgtcgcaatg gcagccaagc cgaaagtcgg atgttccgct 1116361 gcatcggcag atcgaacaat atatgaaaga caagattctt cacggagagt gggctgtagg 1116421 gacgaaaatc ccctcacaga gaacgctggc cgacatgttt caagtcaacc gcagcacagt 1116481 cacagcagcc atagatgaac tcacgtctca aggcttgtta gagggaagaa aaggcggcgg 1116541 tacgaaggtt gtaaacagta cttggagcgt gctgacggct gagcctccgc ttgattggag 1116601 cgattacgtc cgttcgggca ttcatcgcgc caattcttcc atcattcaag ctattaatca 1116661 gaacgaacca agagcggata tcatcagatt aggaactgga gaactttcac cggatcttgt 1116721 gcctgctgac acaattggac ggatgtttca gcaaatcaat ccgggcgtcc tgtctttagg 1116781 atatgagcag ccgaaaggaa accgtcagct gcgggaggca gtggccgacc atttaaaagg 1116841 aaagaagatc catgtgtcac cgtctgcaat tttaattgtg tccggtgcac ttcaggcact 1116901 tcagctcatc tcaattggac ttttaaaacg agattctgtc attttgacgg agaagccgtc 1116961 ctaccttcaa tccttgcatg tatttcaatc agctgggatg cggcttcgcg gcttgccgat 1117021 ggatgatgaa ggggtcaaag cggggcttgt ttcttctaat cgaaaacaat atggaggaca 1117081 gctgctttac acgattccgt cgtttcataa tccgacaggc acagtcatgt cagagcagcg 1117141 aaggaaagag atcatcagcc tgtcaaaaaa agagcagatg cccatcattg aggatgatgc 1117201 gtacggtgat ttatggtttg aagaaaaacc gccgcagccg ttgaaagcaa tggatcatga 1117261 gggcaatatt ctgtatctgg gcgcgttttc aaaaacggtt agccccggtc tgcgaatcgg 1117321 ctggcttgcc ggtccggagc cggttattga aaggctggcg gacattaaaa tgcagacaga 1117381 ctacggatca agcggcctgt cccagtgggc ggctgccgag tggctgtcac agggatatta 1117441 tgaagagcat ctgacttggg tacgcaggaa gcttaaagaa aggagagacg ccgccgttca 1117501 ttttctcgag cggtatgccg gggacattgc cacgtggcgg attcccgcag gcggctttta 1117561 tatttgggtg acatttcaca aaaacctgcc tgtcagccgt ttcttttatg aattgctgaa 1117621 acggcaggtg cttgtgaatc ccggctatat ttatgacggt gaagaccgaa acagcatcag 1117681 gctgtcatat tcctatgcat ctcttggaga tttggaaact ggcattaaag cggcagctga 1117741 aacagcacgc cgcctgatga tgtcctaggc tttggttata cgatgacagc tcccagtgcc 1117801 ctggcgaagg caatcgcgtg ctcaggtgcg attttgcagc ctttcaattt gtcgagggag 1117861 acatgaagct gttcaaaacg gcacgtgctg atgtccatgt tttgaaggga cgtgccggta 1117921 aagctggcgc cttccaattc gcatccgtca aagtgtgtct gctggagcac cgtatcgctg 1117981 cattcacttt gcataagagc acagtgatca aatcgaactt gtttcatatt tgagtacgaa 1118041 aatgagctga aatgtccgtg gcattcctcg aatgaaacat tccgcagcgt tgcttccgcc 1118101 acattcattc caaccatttt tgactgctta actgaagttc tgtgaatgac agccccgctg 1118161 aaatcggcgt ttgataaatc gcatttttca aagatcacat cggtcagttc aatatgccga 1118221 aaagacacat cgataaagac gacatttctg aataccgttt tttcaacaca tagtctttcg 1118281 atatcttcgc cgcagatggt gcaatcttca aacaaatgca tgctgattac atcatcctgt 1118341 gtcacggcat catgaaaatc tgcggtttgc aggttttccg gtatgttcgg tttttgaatt 1118401 gcgattttat tcatgtgatg acatcctttg ctgcccgaaa aacagaggct tccgggttca 1118461 atttaataga tcgttaagga aattgataca tatagtaaat cgtgaagagc cttttcttgg 1118521 tacagcagcc cgcttgtttt gtaagcataa atggaaagct tcctatacgt caaggcgttt 1118581 acaggccgaa aaagccaaag ggaacaggag gaatgcggaa tggggcatta catcaaaacc 1118641 gaggagcatg tgacactgtt tgtagaggat atcggacatg gaaggccgat catctttttg 1118701 cacgggtggc cgttgaatca taagatgttt gaatatcaaa tgaatgagct tccgaaaagg 1118761 ggatttcgtt ttatcggcgt tgatttgcgg ggatatgggc aatctgaccg cccttgggaa 1118821 ggctacgatt atgacacgat ggccgatgat gtgaaagcag tcatttatac gctgcagctt 1118881 gagaatgcga ttcttgccgg tttttcaatg ggcggcgcaa ttgcaatccg ttatatggca 1118941 aggcatgaag gagccgatgt tgataagctg attttactgt ctgcggcggc ccccgcgttt 1119001 acaaaacgcc cgggttatcc gtacgggatg aggaagcagg atattgacga tatgattgaa 1119061 ttgttcaaag ctgatcggcc caaaacactg gctgatttag ggaaacagtt ttttgagaaa 1119121 aaagtgtctc cagagcttag gcagtggttt ctcaatctga tgctggaggc ttcctcctac 1119181 gggacgatcc actcgggcat cgcattaaga gacgaagatc tcagaaagga acttgctgca 1119241 atcaaggtgc cgacgctgat cctgcacggg agaaaggata gaattgcgcc gtttgatttt 1119301 gcgaaagaat tgaagcgcgg catcaaacag tcggaattgg ttccgtttgc aaacagcggg 1119361 cacggagcat tttatgagga aaaagagaag atcaacagtt tgattgcgca gttctccaac 1119421 tcataagaaa aaacccgaca ttgatcgggt tttttatata attcctctgt tttgcagtgc 1119481 gttaatgatg agatcagctc catcggaaat agaggtctgg tcagactcaa tgatgaaatc 1119541 gggtgaaagc ggcgcttcat acggagaatc gatcccggtg aaatgtttga tctctccgtt 1119601 tcgcgctttt ttataaagcc cttttggatc gcgctgttca caaacatgca gcgggcactt 1119661 cacataaatt tcgaagaact cacctttagg aaagagcgct ctaaccatgt cccgatcctc 1119721 tctgaatgga gaaataaaag ccgttaaaat catttgcccg ctgtcgacaa acagcttcgc 1119781 cacttctccg atccggcgga tgttttcaat cctgtcacca gtctgaaatc caagatcttt 1119841 gtttaagccg tggcggatat tatcaccgtc aagcacgtag ctctgaatgc ccttgcggta 1119901 aagcttttca tcgacagcat tggccagcac cgattttccg gagccggaca aacctgtaaa 1119961 ccaaaggacg cagcttttgt gtccgtttaa ggactgtctg tcagactttg agatggcagc 1120021 gggatgccaa atgatgttcg gattgtgtgt cattgcaatt ccccgctgtt ttgcttgatg 1120081 gcaacaggct gttggtgaag tcccttgatc agcacggctg cgacctcagg ccggctgaat 1120141 tctttaggcg gctttttgcc ttggcggaga agctctctca cttttgtgcc tgataagtgg 1120201 atgtggtctc tcgggctgtg cggacatgtt ttggaggtgc ccatgtttcc gcattttcgg 1120261 caataaaagc tgtgctcaaa aaacagcggc ttgatgccca gctcttcctc tgtgaatgat 1120321 tgaaaaatat tttgggcgtc gtatgttcca tagtagctgc cgacacccgc gtgatcacgg 1120381 cctacaataa aatgggtaca gccgtaattt tttcggacga gcgcatggaa aatcgcttcc 1120441 cgcggacctg cataacgcat ggcggcaggg aaaaccgata acatgacacg atcctttgga 1120501 taatagtgat taagcaaagc ctggtagctc tccattctga tatcgctggg gatatcgtct 1120561 gactttgttt ctccgacaag tgggtgaagc agcagaccgt cgaccgtttc taacgctgtt 1120621 ttttgaatgt attcatgcgc tctgtgaaca gggttcctgg tttgaaagcc gacaatcgtc 1120681 ttccagccga gtttttgaaa ggccgctctt gtttcagcgg gcgttgcata aaactgttcg 1120741 aaagatttgt caggcaggct gctgaccgtg ataggccctc cgatatagta atccgggcgc 1120801 gccagcaatt tttttacgcc tgggtgggca ggatcgtttg ttttaaaaac agacagtgct 1120861 tcttgtgttt tatcaggctg gtatatatcg gtgactgtga tcatgccgta ggtaacaccg 1120921 tctttcacaa gcttgacgtg atctccggca gacagctgtc ttgctgtttt ttctccgaca 1120981 ggcagcgtaa tcggcaggct ccacggcaag ccgtttgcca gcctcatctc tttcacaacg 1121041 gaatgataat ctttttctcc caaaaaacct gttaacgggc tgtagccgcc gatcgcaata 1121101 agctccagat cactcagtgc aagctgatcc agctctgctt ggcacgcgca cccttcaaaa 1121161 tggcatgcgg gatcacagcg gttgattaat acccctccgt ggggttcgtt tccattcaac 1121221 gtgttcaacc tccatttata cgtttccttg ttttcttttc tgcacttaat gaaagtttga 1121281 catcagcgcc ttaacatcat ttcgattctc acatcaagaa cctgccatcc gctattcttg 1121341 atgcaggccg cattctgttt tctcccgtcc ggcccatctt ccagccctct catcgttcgg 1121401 gtccggggaa ggcagtgtac acatttcaca gcctatgctc ggataatgtt gatcgtgcag 1121461 tttgttataa ggcaaattgt gcaggcggat gtacgtccaa acgtcatccc atgtccagtg 1121521 gataagcggg caaattttga tgagctcaaa cttctggtcc aggtttacgt attgaatatg 1121581 ctttctcgtt ggtgactgat cccggcgcag tcctgaaatc caagctgtca tgccggacag 1121641 gtgctttttg agcggttcga ttttccgcaa ttggcagcag aggttcgggt tatgcttcca 1121701 cagctctccg ccgtacttcg tcccctgttc tgttaagctc agctcgggtt cgagcatctg 1121761 gattgcaaat cccggatatc gttctttgac ggtctcgatc agctcatatg tttcctgaaa 1121821 atgaagcccg gtatccaaaa agatgatgtg tgcgtttttg ttgatttttg atattaagtc 1121881 gagaagcacc attccttctg cgccaaagct gcaggcgtac acaatctttt ctccgtacgt 1121941 tcggtaagcc catttcaaca catcgagctc atcgatcaat tgatccgtta tctgtttgga 1122001 cagcatgtcg ttccaagtgt catatgtgat ggtttcgttc aatgttttcc ccccgtttgc 1122061 atctgctttt tttatctatt gatcgagtta taggcagact attcattttt tgcataaagg 1122121 ttcaggtttt aggtgccgcg cccgcctaaa atgaggtgcg gaaccattaa gagcccggct 1122181 gaatatgctt tttagcaaaa tggttttatg cccaaggaga ggtagtatgc cgattgccat 1122241 ttatcagggg catcatcatt cgcttgcccc ggcggacatt aacatcgtca ttgatgtcat 1122301 cagagccttt acggtcgccc attatgcgtt tatcggcggg gcgaaagaga ttttgttggt 1122361 ccggacagct gatgaagcct ttgcgctgaa agacacctat ccggattatg ttttgacggg 1122421 agaggaaaag ggggtcggta tcagcggatt tgatttagat aattctccaa aacgtatggc 1122481 tgggcagaat atgacggata aaagcctgat ccagaaaaca acaaacggcg tcacagcagc 1122541 attgggggcg ctgaacgcaa agcatctgtt cgtaactgga ttttccaatg ccaaaacaac 1122601 ggcacagcat gtgaaaaagc tcgtcgcaaa cgattgtgtc ataaacatag tggcttccca 1122661 tccatccggt gatgacgata tggcatgtgc ggagtatatc aaaggcatca ttgaagggac 1122721 aaatgtggta acggctgcgg aggcgattga aagaataaaa ggctcttctg ttgcggagaa 1122781 gttttttgac tgccgccagc cattgtttga ttcggaagac atcgtttact gtacaaaaga 1122841 actgacgggc gatttcgtga tgaaagtgaa acaagatgga gaagttccaa cgatagagag 1122901 ggtcataata tgaatgattt ttcactagaa ttgccagtga gaacaaacaa gccgagagaa 1122961 accgggcagt ccattttaat tgataacggc tatcccttgc aatttttcaa agatgcgata 1123021 gccggagcgt ccgactatat tgattttgtg aaattcggct ggggcacatc attacttacg 1123081 aaagatcttg aagaaaaaat cagcacactg aaagaacatg acattacatt tttctttggc 1123141 ggcacactgt ttgaaaagta cgtaagccag aaaaaagtga atgaatttca tcggtactgc 1123201 acctatttcg gctgtgaata tattgagatt tcaaacggta cgctcccgat gacaaataaa 1123261 gagaaagcgg cttacattgc cgatttttct gatgaatttc ttgtgctcag tgaggtgggc 1123321 agcaaggatg cggaattagc aagccggcaa agctctgagg aatggcttga atatatcgtt 1123381 gaggatatgg aagcgggcgc ggaaaaagtg attacagaag ccagagaaag cggaacggga 1123441 gggatctgtt ccagcagcgg cgatgtcagg tttcaaattg ttgacgacat catttcctcg 1123501 gatattgata tcaacaggct gatttttgaa gcgcctaaca aaacgcttca gcaagggttt 1123561 attcaaaaaa tcgggccgaa tgtgaatctt gccaatattc catttcatga tgccatcgcg 1123621 ttggaaacgc tgcgtttagg gctaagatcc gatacctttt ttctgtaaaa tagcggctgc 1123681 ggggctctcg tcgtgaagag agcctctgcc tattattttt tatggcggta cataggcgtg 1123741 agatagggaa gtgaggtcag gcggatgttg tagatgaagt cgatgactct tgtcgatatc 1123801 acctggcata tgagggcttg aatgacgatg ccccagtcaa taatagacgc ggtgaccata 1123861 aaaatgatgc aattcatgat gagcaggatc gttccaggat tcccgccgcg gtagatagaa 1123921 atcatcagag caagggctcc gaatcctccg ttcgaaattt tatatttgta taaaagtccg 1123981 attccgagtc ccaataacac tgcgccgctt gccagatcaa gccacaggtt agatgtgata 1124041 tcaggaaaaa ctgcatcaaa gatcaatacc gagacagagg tgacggtgat agaagcgagg 1124101 gtgccggtga atgttctcat ctccagccat tttaaagcgg taaaaagcat tgatacattc 1124161 acagcccaca ctgaaaatcc gtgggggatt tgaaacagat aatgcaatag caccgcaata 1124221 cctgctgcac cgcctgtcgg aatatcatgc ggaaataaaa acaaggacat gccgagtcct 1124281 tgtagtacgc cgcctacgac aatcataaac gtaagttttg ctttcatcag cagttcagcc 1124341 attaagtcat ttgctccttt atgaaaagac ttgtccgctg ttttcatttt atgaggctgt 1124401 ccattattta tgtctcaaaa taaagaaatg gcccagctta ataggctgag ccatcccact 1124461 tgtagcgatt gacgatctcc atattgatct ctgtgccaat gccttttcct ttcgggatgt 1124521 ggaccattcc ttttgaaggc tgcaggctga cgagatctgt aaaaggattc tccatgacgt 1124581 cccactcgat cggttcaatg tgatcgttct tcattttaga ccatgggggc agacaggctt 1124641 gtgcaaataa agcatagagc cgtgagagcg atccgtcata tgcatgggcg gatgctctga 1124701 cgccgaaata acgcgcgagc tggaggcagt cccgaaactc atcaattccg ttgacatgca 1124761 tgacatcggg ctgaatgata tccaaacagc gctgtgaaag gagaggcaca tattgcgccg 1124821 ggcctttcat gttttctccg ccggcaacag gaacagacaa acggcttcga agcatagcgt 1124881 aatcctgcgg ctgatcaaag ggcaaaggct cctcaagcca gccaatgttc gtccattcgg 1124941 agaaatagcg ctcccattta aaagccgcag cggcatcgta gctttggttt gcgtccagaa 1125001 tcatcgtaat ggagctgcct gctgtatgct gcagcgcatt gatgtgccgg acatcctcct 1125061 tgaatgaagt cccgccaatt ttgactttga tttgctcaaa accttttttc aactgggctt 1125121 caacattgga gactgagcgg ctgatccatt gcggggagtc tgagtacgat tgaaaagacg 1125181 cgtacacagg aatctcctct ctgtatcgcc cgccccataa ttcgcaaacc gaacaatccg 1125241 cagctttggc tgcaatctct gtcagcgcca tgcttacagc ggaggccgcc cgctggtgcc 1125301 atttttgaat cgtgcgcact aatgacaggc ggctgccagc ctgttttcct aatagaaatg 1125361 ggatgatccg cttcgtaaaa ccgacatgga gagcagggag ccaatcaacg cattctcccc 1125421 agccgtctat cccgctttcg gtgataatcc tgatgagata acaagtccga tatcgtttaa 1125481 acccattggc atctccgtat ggcttttcta atcgatgaaa tagcggaaag gtttcaatcc 1125541 gtacaatttt cacactgggt gctacctttc ctcagcgggc tggagccgat tgccagccat 1125601 tttagggtct tctttttctt ttgtttcttc attgttttgc ttcacatgga tgagcatcat 1125661 cacaagaatc ccgacaacga gagtcaatcc cgcgatgctt aaaaacatgc cgggtctgga 1125721 ccattgcatc aggcggccga aaatcggagg accgatcgct acccctaaga aacgtacaga 1125781 gccgtacagc gaggtgacaa atccccgtct ttctttgccg acagccccgg taatgaaact 1125841 gttcacacaa ggaaggacaa gacctgagcc tatactgctc agtacaagaa cactgataaa 1125901 aaggacaaga ttttcaatga atgacagtgc cgcgtaggat acggtcatga acgccaatcc 1125961 aagtacgatc agctttttca ttaacgattg cttttgcccg attttgcttc ctgttgtata 1126021 ggacgtcaca cacataacca aaagcgggat cgctaaaatt aagccttttt tcacgccgtc 1126081 ggtgtcgtat gttttttcaa gaacatctga gagataaaac aggatgccga ataaagtaaa 1126141 caaacaggtc gcaccggcta aataagcggt aaacagccat ctgccttcat gtttaaagac 1126201 acttaacagc ccttttgcat attgtccgat tggtggcggt tctttttcct ttttcttttc 1126261 tttaataaaa atccaagtca gtacgatcga aatgatacaa aacacaggaa aggcaaaaaa 1126321 cgcgccatac cagacaagca gggcgatcag cgagccaatg atcggcgata gcactttccc 1126381 catgccgttt gaagcttcaa caaggccgag caccttgctc tcctgggcgc ctttaaacag 1126441 atctcccgtc agtgccatgg caattgggcc ggttccggct gccccgattc cctgtaacgc 1126501 tcgtcctgcc atgacccaag gataggcatt gtcaaaaaaa cctgccgcaa acccggctaa 1126561 caaaccgccg gcaccataca aaattaagca gggaataatg atgactttcc ttgagaatcg 1126621 gtctgcgaga taaccgacaa tcggaatcgc aaatgctgca atcaaggaaa atactgtgat 1126681 cacgagactg acttgaaatt gtgataaatg aagttcagat ttcatttttg gcaaaatcgg 1126741 aataagcatc gagtttccta gggttaatat taaagggatt gaaccgattg ccacaatcgt 1126801 cattccgtta ttttgttttg atgattccat ctcagagcac actccttttc ttctgcttag 1126861 aatgtccctg atggcttcgt ttattcagcg atcagacagc aaaaaaccga acagaagata 1126921 cctgttcggg aaaaaagagg gttaaccgag agcctgtgaa atcaaagcat ataagtgtcc 1126981 attttgaata ggcgcttttt tctgatagaa caaaatcgga ggttcatcat ctttatgaaa 1127041 tcccatttct atcaggctgt catgcagaga cgtgtgttca ctcggtatat cgattcgcat 1127101 cggcccttgt ttgccggccg ccagccttgt aattatctgt gctgcaacat ctgatgatgg 1127161 agcgatgata gggccgaatt tcaaattggc cggtgtctgt acagaaagtc cgtagccaat 1127221 gagctgtccg tcctgatttc tggcgatgat acattcgcat gaagcagaaa taagctgctg 1127281 caaaaggttt gatcgatctc cgccaaaggc agccagatcc gccgcggtta agtcgtgaaa 1127341 gtcttgttct ctaaaggatg tcagttcagc atcaagcttt tttgtataag gttgaaaact 1127401 gtgacagctg tactttcgca ctgaacctgc cgtatgaaaa cctgcttttt cataaagcgg 1127461 caaaccttct tttgtggcgc aaagcctgat ggcggtgttt tcatccgttt gggtaataca 1127521 ggcgtttacc atacgccggc caagaccgag ccgttgatat tccttgtcaa cgataacaag 1127581 gccgatagaa gtaagacggc caaacaaaaa caagccgatg caggaaataa tatcaccgct 1127641 gacattttga taaccgaaaa agcgtccctg ctgaacaagc agtttcagct cttgttcgcc 1127701 ataatccggc cacccggctt gcccgcaaag ccgcaataag ccggaaacgt gttcttcatg 1127761 aagcttaatc agttcatcta ctacgtccat aagatcacct gcttgttcta agtgttttgt 1127821 acatgacaat atgattgcca atgccgggaa tgtcaaatgg ttcgccaagt tccttccagc 1127881 caagcttggc atagtagccc ttgacatggt gtcttgcgtt gcaccatacc gcctgaacgc 1127941 cgctctccgc cagtttgtgc tccgcgtgtt tgatcagcgt gcttccagct ttttgatcgc 1128001 gatatccctc gagcgttgcc atgcctctca gccgatacgc agaggcttcc gttaataaag 1128061 gctgactttg cggggaaaaa gaagcgatgc tgatcagcgt tccatcataa aacacgccga 1128121 gatgaaagga gccttctgcg tgatcctctt tatatttgca ttgttcgatg gattgatggg 1128181 gacgcagaat gcgatgccgg atttcatatg tatcttccac ggaaatggtt ttgacttcga 1128241 gcataatgtt cctcctcatg attgtttttc tatatcgtaa cacgaatctc gttgaaaaag 1128301 actgcccgat tcgatcaggc agtcttttgg aaattaatgc aaaaagatat tttggcgctg 1128361 ctcatctttt tgctgaatat atgatgtgag ctcagcggtt aagtcagatc tgaggaaagg 1128421 cgttatcaag tagatgccgt taaacagctc gcatgccgta tccagcaggg agcgtgcaat 1128481 tgcaaggcct tccgcctttt gcttttcttt atcttcaccg gcatgggcca ttttttcgcg 1128541 aatcgtatca gacagcttaa tgccgggaat ttcattatgg atgaattcgg cattccggct 1128601 gcttgtcagc ggcatgatgc cgatatagat cggcgtcttc agatgttttg tttcgttatg 1128661 gatatcgaca agctgctgct cggaatagac aggctgagaa acaaaataat ctgcgccgca 1128721 atctattttt ttctcaagcc gttttaccgc tttatccaga tggcggacgt taggattaaa 1128781 tgcggcggca actgagaaat tcgttttctt gccgagcggt tttccagaca gagacagacc 1128841 ttcattgaat tgtttgatca gcctgattaa atcaaaagat gttaaatcat atacagacgt 1128901 cgccccagga aaatccccga ttttagaagg gtcacctgta atagcaagca cgtcattcag 1128961 ccctaacgta tcaaggccca ttaaatgtga ctgtaagccg ataatgttac ggtcacggca 1129021 cgtaatatgg acaagggaac gcatatcgag ctgctgcttg acaagggcgc cgcaggcaac 1129081 attgctgatc cgcggggtcg ccaaagaatt gtcggcgagt gtcagggcat cgattcccgc 1129141 ttcttttaat tcagcagcag cggacagaaa tttgtcaaag cttagttttt tcggcgggtc 1129201 cagctctacg ataatagagc gttttttcgc tgcgatctca tccaggccgg gctcggttcg 1129261 ctcgtgatga acagaaatga attctttcgc ccgggttttg acttcttttt ccgtaatcgg 1129321 agccagcccg ccaaccgctt ccgccatcgc cctgatgtga ttcggcgttg tgccgcagca 1129381 gccgccgata atccgcgcac cttgcttacg gaattctgac gcgctgtttt gaaaatacgt 1129441 gtcgtctgtt tcatagacga gccgtccctc ttcaagcgaa ggaagactgc tgttcggata 1129501 aacggataag aatacgtcat caaaaatcgg cacttcgctt agcgcttcaa tcatgtgata 1129561 agggccgagg cggcagttaa tgccgacaat atcagctccg agatccgcaa tcgagcgcaa 1129621 tgcgtcagaa agcggcgttc cgtcctgcaa tacgccttgc tcgtgcatgg agacattgag 1129681 cataatcgga agatcagtct ctttgcgcgc gattttcagc acttcacggg cttcttccaa 1129741 atcataatat gtttctaaca gcaagccatc cggctcttca tgcagcagca gatacagctg 1129801 ctcgcggaag ctgcgcttaa tttcgtcaag actgtatgcg tttttattaa atgtgcgtat 1129861 gccgcccatc gttccaagca cgtatgcatc gcctgctgaa gcccgcgcga tctttacggc 1129921 ctcctgattc atttttttga tgtcatcctc aagcccgtgt ctggataatt taatatagtt 1129981 ggctccgtac gtattcgttt gaataatgtt ggctcccgct tcaacgtacg ctttatgtat 1130041 gcgctgaatt tcctccggct ttgaaatatt gagctcctca aaacacctgt caatgccata 1130101 ggagtagagg agcgtcccca tggcgccgtc accgattaac acctgtcttt gcaaatcttc 1130161 taaaagtccc attgtctgcc tcctttattc acatcagcaa ggaaaaaaga gaaataaaaa 1130221 aagtcctctt aagaagaaga ctttgtcagt gattttgtct cttcttatct tccaagctgt 1130281 tcgagcttgc tggatttagc accttggtca tggctgatcg ccattacacc ggttgctgaa 1130341 gcttcgtcgg gccagtccct ctgcttctct tgataagaac ggatatgaaa ttttcgtgtc 1130401 aggaagtgcc aaaagatatc tggcgttttt ccctttctcc aaatttaccg aaaataaaga 1130461 caataatcaa taggaatcag aaaatttatc tgaaatttat aaattgaacg tcaattggca 1130521 gatctgctcc ccgtacagct gagataatct gctgcaggtc atctttgttt tttccggtga 1130581 cacgcacttg atcatcctgc acctgagact ttactttcag tccggagttt ttgatgatcg 1130641 tattgatttt ttttgcgttg tccttgtcaa tgccttgaac aagctttgca cgctggcgca 1130701 ccgttccgcc tgacgcgttt tcaaccttgc cgtaatcaat gttttttgtc ggtacgtttc 1130761 gtttaatcaa tttgctgacc agcacatctt tcagctggct taatttgaat tcgtcatcgg 1130821 aaacgaggac cagctcctct ttatctaaag aaatgtcgct tttgctgcct ttaaagtcat 1130881 atcgggtact gatttccttc agtgcgattt ggattgcgtt ttgcacttca ggcaattcca 1130941 ccttggatac aatatcaaat gaactttctt ttgccatatg aaaacctcca taacatttaa 1131001 cttatgtgtt gattatagta gaataaagag aaacttccaa cagaacaaag aatcaatttg 1131061 tgatgattgg aaaaaatgtt aacaaaatcc gcagagaata agcggaacag gaaggacgat 1131121 agcatgagac cagggcagca attaaccttg agtatagatc accaaaccga cttcggttac 1131181 tttttaaccg atggggaaga tacgattctc ttacataaca gtgaaatgac tgaggatatc 1131241 gaggacagag acgaagtaga agtctttata tacgtagacc agcaggaaag gcttgcggcc 1131301 acgatgaaaa ttccgatcat cagcgcggat gaatatggct gggttgaagt ggtggataaa 1131361 gtggaagata tgggcgtttt cgttgatgtc ggtttatcga aggacgcact agtcgcaact 1131421 gagcatttgc cgccgtacga agatgtctgg ccgcaaaaag gggacaaact ttactgtatg 1131481 ctgaaggtga cgaaccgggg gcgcatgttt gcgaaaccag cgccggaaga tatcatcagc 1131541 gaactgttta ccgacgcttc agaagatctg atgaataaag agctgacagg tacggtgtac 1131601 aggctgatcg catcgggttc attcgtgatc acggatgacg gtatccgctg ttttattcac 1131661 ccgtcagaaa gaaaagagga gccaagactg ggttcaagag tcacaggccg ggtgattcaa 1131721 gtgaaagaag acggttcagt caacttgtcg ctgcttccga gaaaacagga tgcaatgtca 1131781 gttgatgctg agtgcattct aacgtatatg agaatgagaa acggtgccat gccgtacagt 1131841 gacaaaagcc agcctgacga tatcagagaa cgttttaata tgagcaaagc cgcctttaaa 1131901 cgcgcgctgg gccatttgat gaaaaacgga aaagtgtatc aggaaaatgg atggacatac 1131961 gagaaaaaat agcatgaaaa cggctcgcct gcagcagact gcggagcgag ccgttttttt 1132021 atgtctagtt taattcatca accagcgttc tgattgccat ttcgcgatcc acattgtctg 1132081 aaatcgcaat cggcgtaata tcaatggcga gaatgatcag aatcagggca cctgctgcag 1132141 caacataaga aacataatag aaatagttag cggtatcaac agtgttgaca agctcggcct 1132201 gaactctgga tgtatcatcc ttagaagcgg cgatttcctt tgcagcttct actttttctt 1132261 caacgatttg acctgctttt ttcagcagtt catccacttt caatgcatct ttgctgtaaa 1132321 cagctttctt caggttatca aaaaagtcag catcctcttt tttaatatca gcgacaacct 1132381 gattggcaaa agcctttgcc tgttttgtgt tgagtttgtc tgtcatcgct ttattaaaga 1132441 cctctggaag ctgtttgcca acttcccctt gggcaaacac aaagccttta aaaatttcct 1132501 cacctgaata ctcaagctgc tttgcctgtg ccacactttc ttgctgcttc accaaaaaca 1132561 cagtcgtcac caatacaacc gacaaaaata ctagaaacgc cttcttcaaa ctgaaacctc 1132621 tcccttcttg tgttttttat tccacaacag tctgcgaata tatgtaaatt gaatcgtgga 1132681 atcgatagga gtgagataca atatcaaaat gccggccatg ataatcgaaa aactgatgag 1132741 gcccagcatg actgcaaaaa tctcatgcat aaaaacagcg atgatcaaaa tcaatctcca 1132801 atgcttcttc ggcgcaaaca gtgccgcgaa gatgacaatt tgaaccagca gcgtccccca 1132861 tgtcggaatc accacgaacg gacttgttac aattggcttc gttaacgcct gaaaaaagcc 1132921 gttgaagcca atggtttttt cctgggcgaa ataatagacg gccgttccgt ccacccattc 1132981 ctgctgagat agcttagcga cggtagagtg aaaataaagc accgccactt ggattctgat 1133041 cacaaaataa gaaataaaag ctgttatttt tccaagtgtt cttttgccct ctataggtct 1133101 cgtactccaa tgccattttc tcggatcggt cagcgtgatg ggaagcaata aaaaggtcat 1133161 gactgctgct gcctgctcgc ctccgtcgat gacgatcagc gatgactgca ggctgtaact 1133221 gacataccaa tgcagaaccc cggtgattct ggggcgccag ccaatgacaa caagcaccag 1133281 aatggcaatg cagacccatc tgaaaagatt taacatcata tagttatttt cgccgagaca 1133341 aaagagactg agattcattt tacaagctgg atagctgctg atcccgctgg ctggcttcat 1133401 aatgaggctc gggtgattga tgagcagcgt cagcaggctg gatagcgcaa tgatgcttcg 1133461 cgcgaggcca tatacatttg tccacgggtt tctttcgtcc catctggtga tggtctgttt 1133521 tatgttttcg agcatgagat cacaaccttg actatgcttt ttacctgata agacgaaggg 1133581 gtatatttag aatagctcca aggaacaata tcctctttcg tcaaatagta gctgccacaa 1133641 agcagcgggc ggggagcggg tgtttttaat tgcacggttt tggctttgct tttgcatgcg 1133701 ccgaggtcct tttctttaca tgctgtccac tgttccttgc cgacttggct gtagatcacg 1133761 cccatttcaa cgccttgtga ccgcccatac cgatacaggc cgaataggtt gtcagccctc 1133821 atattgggcc atctgacctt ggcgctggca ttttcagcct catataagcc gattgcagta 1133881 tcacgcggat ttttgctaaa aaagccccag ccctgaggga ggatgctgga catgagaaat 1133941 ttggagtcct ttgtcagcgg aatcggggtt gtccctaagc tgccaataat agaaaacaga 1134001 aatagcgaac cccaaaggat tgaaaaaatg acaaaaaatg atatcgattt ctgcattcga 1134061 ctgctccttt taacctgaag aatcgttttt acacttttca taatataaaa acatttatgt 1134121 aataaaaagg ttaaaaagta tgagaaattc catttttgtt aaaaggaaaa acaggacatt 1134181 ttacactgct atatgtgatt gatatatagt gtttttttcg atatatttaa accatgaaaa 1134241 cgaatcaagt taatgaccgc tggattgttc aatttcgaaa agggattttc gagctggcca 1134301 tcctatccct tctgcgttct aaaccgatgt acggttatga gctgacgtca tccttaaaaa 1134361 ccacctcggc gctggctatt tcagagggag cgatttatcc gattttgaaa cgtatgaccg 1134421 agaagggatg gatcgaattt ttttgggaag attcactgga cggcccgaaa agaaagtatt 1134481 acaaaatgac gcaaaaagga gaagaaatgt taaaagaacg gctggagaaa tacctggaaa 1134541 cccatcaagc cttactgtct ttatcggggg atttgctatg aatggacagc ttatcattga 1134601 ccgatacatg gaggaactaa atgcagagct ggcgaatatg cctgatgtag agagagaaaa 1134661 cgctatcgac gaattaaagg ggcatatcac cgctttcgtt caagacagaa tcaaagccgg 1134721 ccttagtgaa gaggaactgc aggaagctgt tgaatctgaa ttttctcatc cgaaggagct 1134781 tgccgaattg atgatgggtg atgggggaga gacgaaaagg aggaggtctt tattgggcaa 1134841 aagctggatt tcggtccttc tcattgtcac gattatcgcc ctgccgctgc tgccgtccga 1134901 cttcagacat ctgccgctgg ctgtttattt aatggtgctc gccggatatg tatggaagcg 1134961 gaaaaaattg gtgatgtttg caggtgtcag aaaaaacaaa atgcgctctc aaaaggagat 1135021 tgtcaagatt tcgcgagtcg gtgcggttta tctgctgttt ttagcagtgg tgctcctttt 1135081 gagcccgttc ctcaatgcgc ttgtcgtcct gctgctgatt gcagtaagct gcgccgcttt 1135141 ttttcttttt cttaacatca agtaatcttg taggaggctg taagatggaa atcagcatca 1135201 attatctatt aattgtcatc gcgcttttat tctttgtggt tgcctatttt gtcggaatca 1135261 aaaaacaaac ctggatgttg gctgggttta acgaggcgcg tatacgggat aaagatcggc 1135321 tggccagaat agcaggctac tttttcttga attccggttt gttcattttg ctgaatagtt 1135381 ttatctcatt tcaaggtcag gagcagctca tacctccgct tatactggca tatggagcag 1135441 gggttattat ttatgtcaat aaaaaattag tagagtagaa aaagaagggc agagcgaaat 1135501 atctctgccc ttcttttttg ggaaaataag aacgaagcac cacatacaag tttttgtatt 1135561 tttgatagga tgaagaaaaa tggtagattc caaaatagga aggatgtggt gttttgcgca 1135621 acttgaccaa gacatctcta ttactggccg gcttatgcac agcggcccaa atggtttttg 1135681 taacacatgc ctcagctgaa gaaagcatcg aatacgacca tacgtatcaa accccttcat 1135741 acatcatcga aaagtcaccg cagaagccgg tacaaaacac aacccagaaa gaatcgctat 1135801 tttcctatct tgacaagcat caaacgcagt ttaagctcaa agggaatgcg aacagccatt 1135861 ttcgcgtttc gaaaaccata aaggatccaa agacaaaaca aacgtttttt aaattaacgg 1135921 aggtttacaa aggaattccg atttacggct ttgaacaagc ggtcgcgatg aaggaaaaca 1135981 aacaagtgaa aagtttcttt ggaaaggtgc atccgcaaat caaggacgtc tccgtcacac 1136041 cgtctatttc tgagaaaaaa gcaatacata cagcaaggcg tgagctcgag gcttccattg 1136101 gaaaaatcga atatcttgat ggggaaccaa aaggcgaatt atatatctat ccacacgacg 1136161 gtgaatatga tctcgcctac cttgtgagac tctcgacatc tgaacctgag cctggctatt 1136221 ggcattattt catcgatgcc aaaaacggaa aggtcatcga gtcctttaat gccattcatg 1136281 aagcggcagg tacaggaatc ggcgtgtcag gtgatgaaaa aagctttgac gtcacagaac 1136341 aaaatgggcg cttttatttg gctgacgaaa caaggggaaa agggatcaat acatttgacg 1136401 cgaagaacct gaacgaaacc ttgtttacgc ttttgtctca actgatcggg tatacgggca 1136461 aagaaatagt cagcggcacg tccgtattta atgaacctgc ggctgtagac gcacacgcaa 1136521 atgcgcaagc cgtttacgat tattacagca agacatttgg ccgtgattct tttgatcaaa 1136581 acggagcaag gattacgtct accgtgcatg tcggcaaaca atggaacaat gctgcgtgga 1136641 acggtgtcca gatggtatac ggggatggag acggttcgaa atttaagccg ctgtctggat 1136701 cgctcgacat tgtcgcgcat gaaatcacac acgcagtcac acagtattcc gccggtcttt 1136761 tatatcaagg agaacccggt gcattaaatg agtccatttc tgacattatg ggcgcgatgg 1136821 ctgaccgtga tgattgggag atcggcgaag atgtctatac tcctggtatt gcaggagatt 1136881 cattgcggtc attggaggac ccatctaagc agggaaatcc agatcattac tcgaaccgct 1136941 acacaggaac agaggattat ggcggagtcc atatcaattc gtccattcac aataaagcag 1137001 cttatcttct tgcagaagga ggcgtgcacc acggtgtaca ggttgaaggg attgggcgtg 1137061 aagcaagtga acaaatttac tatcgggctt taacatatta tgtaacggca tctacagatt 1137121 tcagcatgat gaagcaagcg gcgattgaag ctgccaatga tttatacggt gaaggctcga 1137181 agcaatcagc ttcagtcgaa aaggcgtatg aggctgtcgg cattctatga gcaaacaaaa 1137241 acagtcagga cacagagtct gactgttttt gtttgctcat tttcttaaaa agaatatcgc 1137301 caatgtacct ggaccggcat gcgagccgat ggctgaactg attggatgca taatgatttc 1137361 tttcggcttg aacgcttcct caatcaggtg tttcatatcc gtggcttttt ctttgttcgc 1137421 ggcgtagcta atcccgacgg tttgattgct ccaatcatcc ccgcgctctt tcataagctc 1137481 gatgatccgt ttgaaaagtt tcttctgtcc gcgaattttt tccagaggca caagcttgcc 1137541 gtcctccatc tgaagcagcg gtttaatatt caacaggccg ccgacaaaag cggacgtttt 1137601 ggatatccgg ccgcccctcg cgagatatgt taaatcatca acggtaaaaa tgtgttcaag 1137661 ctggctgcaa aagttcttta cagacgtttc aatttcttgt attgtattcc cgttgataca 1137721 gagatcggca gcatgccgga cagccagacc gtatcctaat gaagcgcatt tggaatcaat 1137781 gacccgcaaa tcgaaatcgg ggaattcctc cttcacttca ttggcgatca ttacagctgt 1137841 ctgatacgtg ccggagagac ctgaggaaaa ggcaatgtaa agagcgggat cacctgtttc 1137901 ggcatattgc aaaaacacat ttttaatcgt ttgcggtgag gcttgggacg tcttaggcgt 1137961 ttctccattt tgcatcgctt caaatatttg atccgcatga attgtgactg catcttcgaa 1138021 ttctttatcg ccgagagaaa ccctgagcgg aataaagcca atgccttttt cttcaaaata 1138081 agaacgaggc aaatcagtgg cgctgtcagc gatgagatga actgtcatat tgcttccctt 1138141 ctttccgtta tcgctcgtta tcatgagagt taagccaact atatcatatt aatttgccaa 1138201 aatcgtgttc aaatatttgt tttaagggaa aacataataa agaagaaaga gcggaggaac 1138261 atgccatggt actagatcaa acaaaaaaat tactcatcgt catcatcggc gctttactca 1138321 atgctgccgg gctgaactta tttttgatac ctgcagatgt atatgccagc ggatttacag 1138381 gtgttgccca gcttttatca agcgtcgttg atcaatatgc ccccttttac atatcgacgg 1138441 gaacgctctt gttcctctta aacattccgg tcggtatttt aggatggctg aaggtcggca 1138501 aatcgtttac agtgtacagc attttaagtg tcgcactcac tactctgttt atggggatcc 1138561 tgccggaaac aagcctgtca catgacattt tgctgaacgc ggtgttcggc ggcgtcattt 1138621 ccgcagtcgg tatcggctta acattaaaat acggagcttc gacaggcggg cttgatatcg 1138681 tcgccatggt acttgcaaag tggaaggata aacccgtcgg cacgtatttc ttcattctga 1138741 acgggattat catcttgacg gcaggattat tgcaaggttg ggagaaagca ttatataccc 1138801 tggttacact atatgtgaca acgagggtga tcgacgccat tcacactcgc cacatgaagc 1138861 ttacggcaat gattgtgacg aaaaaagcgg acgaaatcaa ggaagccatt tacggaaaaa 1138921 tggtgcgcgg catcacaact gttccggcaa aaggagcatt tacgaacgaa cagaaagaaa 1138981 tgatgattat cgtcatcacg aggtatgaac tgtacgattt agaaaagatc gtcaaagaag 1139041 ttgatccaaa agcatttacg aacatcgttc aaacgacagg gatttttggt ttctttagaa 1139101 aagactgacg aaagcaggtg gaagtcgtga aacggctgct tgtgatgctc ctccccgtgc 1139161 tgcttttgat aggctgcggg aaagatgagc agacagaacc cgataaggag gtatcaggcg 1139221 gaatggagaa tcaagaggtt gttttatcta ttgacgcaat tcaggagcct gaacaaatca 1139281 agtttaacat gtcgctgaag aaccaaagcg aacgtgctat tgagtttcaa ttcagcacag 1139341 ggcaaaaatt tgaacttgtc gtgtatgatt ctgagcacaa agaaagatac cgttattcga 1139401 aagaaaaaat gtttacgcag gcttttcaaa acctgacgct tgaatctgga gaaacatatg 1139461 atttctctga tgtgtggaag gaagtccctg agcccggaac ctatgaggta aaggtgacat 1139521 ttaagggcag ggcggaaaat ctcaagcagg ttcaggctgt tcagcagttt gaagtcaaat 1139581 aagaggctat ggcgagtcgc catagccttt ttttattgca gtttgtccag ctgattttga 1139641 aattgatgca actgttgacg ttccgcatct gtcgaattgg catacgcaga agatacagca 1139701 tttttggctc tcagaatcgc ttgctcctga tcgccttcct caaagccgtt tgtcaccatg 1139761 accgcctgtt gaacaaatga ttttgcctgc tgaaacagtt catttctcat ttaatattca 1139821 tactgccttt cagccgagtc tcgtgccgcg gcatgctggt gagcttcttc taaagtagac 1139881 cgatatggaa atcttgcggc gtgtagcccg atggagtctt taccctgctg aataaacctt 1139941 ctggatttgc ttcgtttacc cattttgaga ctgccccctt ccatactttg acgagatgag 1140001 tcgtcttcaa tagtatggtg gggtaaagta aggtttatga gtgggaaaaa ttaatacgga 1140061 ccttctttaa agtgagaaat attctttcaa aaaccttgcc acgccgtcct cttcatttgt 1140121 ggccgtagtt cggttggcaa tctgcttgac cgcgtcaatt ccatttccca ttgcaacgcc 1140181 gcagcctgca aattcaagca tttccaaatc gttatcctca tctccaaaag caatgatccg 1140241 ctccctcggc acgccgtaat aatcgctgat tttctgcagg ccgaccgctt tattcatgcc 1140301 gcttttgata atttcaatga catgccaagg agcggcccat cttctatggt cgatcacctc 1140361 ggcatgcaca tccgataaat atgagcgtat tgccggcaca tcctcttcct ttgcatgtat 1140421 gagtacggac gtcacatctt caccgagatt ttcccgcaag tctccgaccg ttacatttgt 1140481 tgtgttcatg ttaaaggcat ctatcaggtg ctcatcatgg taatgaaagt atacgtcgtc 1140541 aatcacttca gcaagcacgt tatgtacgtt gtagctctcg ctgatatcca cgagctgttt 1140601 gacaacatca agcggcagtg acgtatgata ccgtccccag ctgtcgtctt gcggatgatg 1140661 gacaaatgct ccgttaaaat tgacaattgg cgttgtcagc tccatctgct ggtagtacat 1140721 ggaacttgaa cgatacggac ggcctgttga gatgcagaca taatgcccgt catcttttag 1140781 gcgctgtatc gtatgaaggg tgttttcaga tatggtttta tcatccttta ataatgttcc 1140841 atctaaatct aatgcgatta aatagggttt tgtctccatg aaaagctcct ttaaccttag 1140901 attttgcttg ttttgcctta cttacagtgt agctttttac catctttatt gtctacatgt 1140961 tacacttatg attatggtta tcctaaggag gggcacattg tgatacaaat tgagaatcaa 1141021 accgtttccg gtattccgtt tttacatatt gtaaaggaag agaacaggca ccgcgctgtt 1141081 cctctcgtga tctttataca tggttttaca agcgcgaagg aacacaacct tcatattgct 1141141 tatctgcttg cggagaaggg ttttagagcc gttctgccgg aggctttgca ccatggggaa 1141201 cggggagaag aaatggctgt tgaagagctg gcggggcatt tttgggatat cgtcctcaac 1141261 gagattgaag agatcggcgt acttaaaaac cattttgaaa aagagggcct gatagacggc 1141321 ggccgcatcg gtctcgcagg cacgtcaatg ggcggcatca caacgcttgg cgctttgact 1141381 gcatatgatt ggataaaagc cggcgtcagc ctgatgggaa gcccgaatta cgtggagctg 1141441 tttcagcagc agattgacca tattcaatct cagggcattg aaatcgatgt gccggaagag 1141501 aaggtacagc agctgatgaa acgtctcgag ttgcgggatc tcagccttca gccggagaaa 1141561 ctgcaacagc gcccgctttt attttggcac ggcgcaaaag ataaagttgt gccttacgcg 1141621 ccgacccgga aattttatga cacgattaaa tcccattaca gcgagcagcc ggaacgcctg 1141681 caatttatcg gagatgaaaa cgctgaccat aaagtcccgc gggcagctgt gttaaaaacg 1141741 attgaatggt ttgaaacgta cttataaagc actaagttat taacaagagc tgaatttacg 1141801 ttatactgta gaaaaaagga gtgagggaac gtggaagaag cattaaaaga aaacatcatg 1141861 ggcgccctgg aacaggttgt cgatcctgag cttggcgttg atatcgtgaa cctcggcttg 1141921 gtatatgacg ttgatatgga tgaagatggc ttgacgcaca tcaccatgac gctaacatca 1141981 atgggatgcc ctttagcgcc gattatcgtg gatgaggtga aaaaagcatt agcggacctt 1142041 cctgaagtga aagacacaga ggttcacatt gtatggaatc cgccttggac tagggataaa 1142101 atgtccagat acgcaaaaat tgcgcttggc attcaataaa acaaaaaagg acagcctgac 1142161 atgtgaggct gtcctttttt acagctgaaa ggagtgaaag gaaatgatgt acctgctggc 1142221 agttttatgc ccgccgcttg ctgttttgtt ttcgggaaaa ccgtttcagg ccttgctgaa 1142281 tctcatattg acctgtatct tttggctgcc gggcgcgatt cacgcctgct ttatcgtcgc 1142341 cgaccgccgt gccgaaaaac gggcaagaag ataatttgga aaaatgagga cgcagtcatg 1142401 gtataatggt cataaaaaca gcagggagag cactatgaaa aagaaattgc ttgcattcgc 1142461 gctttgtact ggcgcgtatg cggccctgtt tgcgtactct gtgaactcag agcaaaaaac 1142521 agccacaagc gagatgacgg atgtcagccg cctgatgcct gtaaaaataa agcagacagt 1142581 gaaagggcag gaagaggaaa tgctcattga cacagtcaaa gaggcaaatc gaaaaaacat 1142641 aaaaatttca atcgccgggg cccagcactc catgggcggc catacatatt atgaggacgg 1142701 catcgttctc gacatgacgg gctacaacaa aatcctgtca ctcgatcaag agaagaaaac 1142761 catcagggtg caaagcggtg caacgtggaa tgatatccag aaatacgtga atccatacgg 1142821 actcgcggta aaagtcatgc agtcacaaaa catttttaca atcggcggat ctctcagcgc 1142881 aaatgcacac ggacgtgata ttcgctacgg ctcgctaatt gatacagtca aatcattccg 1142941 gcttttaaaa gctgacggga tgattatcac tgtcactcca aaagatgatt tgtttacggc 1143001 ggtcatcgga gggtacggcc tttttggcgt gattcttgat gtaacgcttg agctgacaga 1143061 tgatgagctg tatgtcatga agacagaaaa aatgaattac agcacatact cagactattt 1143121 ttcaaagcat gtaaaaggaa atccagatgt ccgaatgcat ctggcgcgaa tttcaacagc 1143181 gaaaaaagga tttctgaaag acatgtatgt cacgaattac gtattggcta atcatcagga 1143241 tcagctgtcc tcatacagcg aacttaaaga agacgagtat acgggagcca caaagtttgc 1143301 actcggcttg tcaagacggt atgaatgggg gaggaattgg ctgtgggaca cacagcaatc 1143361 ctatttcctg agccagaacg gcacagagat ttcacgcaat aacgtcatgc ggtccgaatc 1143421 aaagtttctt gagtatgaaa acaatgacaa cacagatgtt ttgcaagaat actttgtgcc 1143481 cgtgaaggag tatgggtcct atattgatga cctgagacaa acgctgtcgg acgaagatct 1143541 gaacctgctg aacattacga tccgctacgt gcagaaaaat gaaaaggccg acctttccta 1143601 tgcgaaggac gatatgtttt cgctcgtact attaataaac gagggctttt caaaagaaga 1143661 ccaggcagat accgcccgaa tcatcaggcg catgacagac gttgccatca agcacggcgg 1143721 cagctattat ctgccttata tgacctacca gacaaaagcg caaatgagac aggcatatcc 1143781 gaaaagtgaa gcgttttttc agaaaaaacg aacctatgac ccggatgagc gctttatgaa 1143841 ttacttttat cagaggtata aataatgggg aaaaacaaat taaaatggct gacattatca 1143901 caaagcagcg tgtttttcgc aagcagctta atctttccgt tttatattct gtttgtgaaa 1143961 aatatcggct caagctacac acagttcggt ttttcctacg gattgttcgg gttgagcgga 1144021 gcgcttattt acccgctcct cggacggctg tctgaaaggt ttgacagccg ttattttctg 1144081 cttctgaact cgtgggggat ggctgttctg cttttatatg tcccgcatat cggaagcgtc 1144141 gttcaagtgt atatcgtcca agtgctgtta gggctctttg gagcgatgca aaagcatgga 1144201 gaaaaagtgc tgatcgctaa ttttacagac agtggagagc gtggaaagaa gatcgggaat 1144261 taccattttt ggacagctgt cttttcagca gcagccatta tgctcggggg ctttctcgct 1144321 gactttttca cagtgcaaat gattttttat gcaagctcta ttctatattt tttgagtgga 1144381 ttgatgatga tgaaaacagg ctgacgcggt cagcctgttt ttttatgcgg ctgaaatgcg 1144441 gcaccgcatc aacgtttttg tgctggagtc gtgctgattt tttttgagcg gaattcccat 1144501 tgaacagaaa atttataaat gaataaaaat attaaatata cgattgaatt aatttttatt 1144561 catgttataa tgttaaataa tttcacaaag accaagaggg tgaacttgtt ttgaaaatag 1144621 gaattgtagg tgctacagga tatggaggca ccgaacttgt caggattctt tcgcatcatc 1144681 ctcatgcaga ggaatgcata ctttattcat ccagcggaga agggaatgtc tatagcgagg 1144741 gttatcctca tcttaccggc ttagcggatc agcagctgaa gccgattgat atgaatacga 1144801 tcaaacacga aatagatatc atgtttctcg ctgcgccgcc cggagtatca agtgaattga 1144861 ctccaaagct ggcagacgcg ggaattacgg ttattgatct gtcaggtgat ctgaggataa 1144921 aagaaccggc tgaatatgaa aaatggtata aacggacagc ggcaccgaag gcggtgattc 1144981 aagaggcggt atacggtctg gcagaactga atcaactgca aattcaacag gcgaaactca 1145041 ttgccaatcc aggctgtttt ccaacagctg ttttgcttgg cctcgcgcca ttggctcaaa 1145101 agaaactgct cgatgaatct ttcgttatcg ttgacgcgaa gaccggtgtt tccggagcgg 1145161 gaagaaaagc atccatggga actcattttt ctgagctgaa cgacaatttt aaaatttata 1145221 aagtcaatga acatcagcac acgccggaaa ttgagcaggc gctgaatgaa tggcagccag 1145281 gtctcgggcc cattacattt tcggctcact tggttccgat gacaaggggc atcatggcga 1145341 cgatgtatac cagattaacc tgtgacctaa ccgcagatga cctgcatgat ttatattcgg 1145401 aattttacca agattcatat tttgtgagag tgaggccaaa aggtcagtac ccgcaaacga 1145461 aagaagtgta cggcagcaat ttctgtgata tcgccgtgac cctcgatgag agaacgaaca 1145521 gagtcacgat cgtctcggta atcgataatt taatgaaggg tgccgccggt caggcagtgc 1145581 aaaactttaa tttgatgaat ggctggaatg aagaaactgg actcaccatc acgccaattt 1145641 atccatagaa cgggagagaa tcgaaccatg attcagttaa gtgaagatca aattgtaaaa 1145701 gtaacaggtg atgtatcctc gccaaaaggg tttcaggcaa agggtgtgca ttgcggactg 1145761 cgctactcga aaaaagacct cggcgtcatt atcagcgaga caccggccgt gagtgcagca 1145821 gtttataccc aaagccactt tcaggctgct ccgatcaaag tgacacaaga cagcttaaag 1145881 cacggaccga cactgaaagc cgtcatcgtc aacagcgcca ttgccaacgc ctgcacggga 1145941 gaacagggct taaaggacgc atacacaatg cgggagagct ttgcttcaca gcttggcatt 1146001 gagccggagc ttgtcgctgt ttcatcaacg ggtgtcatcg gcgagcattt agacatggaa 1146061 aaaatccacg cggggatcga actgctgaaa gaaacacctg cgggatcagg cgattttgag 1146121 gaagcgattt taacaactga tacggtgatc aagcagacgt gctatgaact ggcaatcggc 1146181 ggcaaaacag tcacgatcgg cggagcggcc aaaggctctg ggatgataca cccgaacatg 1146241 gccacgatgc tgggatttgt gacaactgac gcggcaatcg aagaaaaagc gctgcaaaag 1146301 gcgcttcggg aaatcactga cgtttcattt aaccaaatca cagttgacgg agaaacatcc 1146361 acgaacgaca tggtattagt tatggcgaat ggctgcgccg aaaacgagtg cctgacagaa 1146421 gaccatccag actggccggt ctttaaaaaa gcgctcttgc tcacttgtga ggatctagct 1146481 aaagagattg ccagagacgg agaaggcgcg acaaaactaa ttgaagccca agtacaggga 1146541 gcgaaaaaca atcttgatgc aaacgtcatt gccaaaaaga ttgtcggctc aaatcttgta 1146601 aaaacggcag tatacggaac agatgccaac tgggggcgga tcatcggagc catcggacac 1146661 tccgcagcac aggtgacggc agaagaagta gaggtttatc ttggcggcca atgcctgttt 1146721 aagaataacg aacctcagcc attctctgaa tctatcgcca aggaatacct tgaaggagat 1146781 gaaatcacca ttgtcatcaa gatggctgaa ggggacggaa acgggagagc gtggggctgt 1146841 gacctgacct atgactatat caaaattaac gcgagctatc gcacgtaata aaggggagcg 1146901 aaatgaagaa aacaatcgtt tttaaatgcg ggggaagcgt catccgtgag ctgtcggagg 1146961 aattttatca aaatctgaaa gagctgaggg cgtcaggctg gaagctggca atcgtacatg 1147021 gcgggggacc ggaaatcaca aatatgctga aacggttaaa tatcaagaca gagttttcgg 1147081 gcggacagag gaaaacaacg aagccggtgc tggaagtggc ggaaatggtt ttatccggtt 1147141 ctgtcaataa atttttcgtt gctgagcttg ccaaacacgg actgcgagcc gcgggcattt 1147201 ctggtaagga tggcggtctt ttggaggctg attatctaga tccggaaaca tacggagaag 1147261 tgggagaaat caaaaaagtc gatgcgtcca tggtgaacgc gctgatggaa aatggcatca 1147321 tccccgttat tgcgccgctg tctatgacaa gcgactgcaa aacgctgaat gtaaatgctg 1147381 atctggctgc ttcagcagtc gccggagcgc ttgaagccga taagctgatg ttcgtcacgg 1147441 atgtcgatgg aatcatgaag gaaaagcagc gtctggacgt cctgacccct aaggagattc 1147501 agatgctgat caagcaggaa gtgatcacag gagggatgat cccgaaggtc aattcagcct 1147561 tgtcagcttt atcagatcag gtgtctgaag tcatgatcgt aaacggtaaa ggatcattct 1147621 tcgcagaaca aacctttcaa gggacaaaaa ttgtcaaagc aaaggaggct gtttcatgag 1147681 cagcttgttt caaacctacg gccgttggga tattgacatc aaaaaagcaa agggaacgta 1147741 cgttgaggat caaaacggca aaacgtacct tgatttcatt caggggattg cggtatcaaa 1147801 tctaggacac tgccatgaag cggtgacaga ggcagtcaaa aaacagcttg acagcgtatg 1147861 gcacgtatcc aacctgtttc aaaacagtct ccaagagcaa gcggcgcaga agctggcagc 1147921 gcatagtgcg ggagatcttg tctttttctg caacagcggc gcggaggcga atgaaggtgc 1147981 gataaagctt gccagaaaag caactggaaa aacaaaaatc atcacttttc ttcagtcgtt 1148041 ccatggccgc acgtatgcag ggatggctgc gaccggacag gataaaatca aaacaggctt 1148101 cggcccgatg cttggaggct ttcactacct gccatacaat gatccttctg cttttaaagc 1148161 tcttggggag gaaggcgata ttgccgcggt gatgcttgaa acagtgcagg gagaaggagg 1148221 agtcaatccg gcgagtgctg aatttttatc agccgtacag tcgttttgca aggaaaagca 1148281 agcccttctc attattgatg aaatccagac cggcatcgga cggacgggaa aaggcttcgc 1148341 atatgagcac ttcggactct caccggatat catcacagtc gccaaaggat tgggaaacgg 1148401 ctttccggtc ggcgctgtca tcggaaagaa acagcttgga gaagcgttta cccctggttc 1148461 tcacggaacg actttcggag gaaacatgct ggcgatggct gctgtgaatg ccacattgca 1148521 aattgtattc cagcctgact ttttgcaaga ggctgctgac aaaggggcgt ttttaaaaga 1148581 acagcttgag gcagagctaa agagcccttt tgttaaacaa atccgaggta aaggattaat 1148641 gcttggaatt gagtgtgatg gcccggttgc tgacattatt gctgaattgc agacattagg 1148701 cttgcttgta ttgccggccg gcccgaacgt gattcggctg ctgccgccgc tcaccgtgac 1148761 taaggatgaa atagcagaag ccgtcagcaa gctgaaacag gcaatcgctc atcattccgc 1148821 tgtaaaccag tgattttttt tcgatataaa ggcataaaaa ttcattttta taattaatta 1148881 ttcatcaaga ggtgggctgt tagatggaag gttatttagt gttagaagat gggacatcgt 1148941 tcagcggcga gctggacggt catgaaaact gcacgggaga agctgttttt ttcacaggaa 1149001 tgacaggcta ccaggaagtg ctgacagatc catcatataa gggacagatt attgtattta 1149061 cctacccgct gattggcaac tacggcataa atgaaaagga ttttgaaagc aagaaaccgc 1149121 aagtaaaagc cgcggttgtc tatgaggcgt gtgatcactt ttctcattat gaagcggtat 1149181 acagcctcaa ggagtatcta cagaaatgga atattccgct gttaacccat gttgatacga 1149241 gggctgtcgt gaagaaaatc cgggcaaacg ggacgatggg tgcgacagtc acagcctcta 1149301 aagaaggagc tgagattgcc cttcaaccag agaatgtggc agagcaggct tccgcccagg 1149361 aaatcagcac attcggcgac gggaataaac atatcgctct cattgatttt ggctataaaa 1149421 agtcaatcgc atcatcactt gtcaaacgag gctgcaaggt taccgtggtg ccataccagc 1149481 aaatggaggc cgtatacaac atcaaacccg atgggctatc gaacggacct ggagatccga 1149541 aagccattca gccatattta ggaaagatca aaagcatcat cagccgcttt ccgactctag 1149601 gcatttgtct cggacatcag ctgatcgcgc tcgcgtttgg agggaatact tttaagctgc 1149661 cattcgggca caggggagct aatcatccgg tcatcgaccg taagacgaaa cgggtcttta 1149721 tgacaagcca aaaccacagc tatgtggttg atgaacagtc gattaatgaa gaagagctca 1149781 ccatcaggtt tcatcatgtc aatgatacgt cagttgaagg gcttgcccat aaaaaactgc 1149841 ctgtcatgag tgttcaattc cacccggaag cccatcccgg acctgcggaa agcgaatgga 1149901 tttttgatga ttatctaaag aatgtgatac cagcaaggag agaaatcgcg catgcctaaa 1149961 gacaccagta tttcaagcat attagtaatt ggctcaggcc cgatcatcat cgggcaggcg 1150021 gcagaatttg attattcagg cactcaaggg tgcatcgcgc tgaaggagga gggctaccgg 1150081 gtaattctcg tcaacagcaa tccggcgaca attatgactg atgaagcctt cgctgatgaa 1150141 atttattttg agcctctgac agcagaaagc ctgacagcca tcattaagaa agaacggcct 1150201 gatgggcttc ttgccaattt aggcggtcag accgcgttga atttagcggt ggagcttgaa 1150261 gaaacgggtg ttttaaaaga gcacggcgtc aaactcctcg gcacatccgt tgaaacgata 1150321 caaaaaggag aggaccggga aaaattccgt tcgttaatga atgaattaaa acagcctgtg 1150381 ccggagagtg aaattgttga taacgaggcc gatgccctcc attttgcgga atccatcggt 1150441 tttcctgtta ttatcagacc agcttacaca ttaggcggaa agggcggagg aatcgcccct 1150501 gataaagaag cctttacagc tatgattaag caggcgctat tagcaagccc gatcaatcaa 1150561 tgccttgtcg aaaaaagcat tgccggcttt aaagaaattg aatatgaagt catgcgtgac 1150621 agcaataaca catgcattac cgtctgcaat atggaaaata tcgatccggt cggcgtgcat 1150681 acaggtgact ctatcgttgt ggcgccgtca caaacattga cagacgaaga ctatcaaatg 1150741 ctgcggacag caagtctgac gatcatctca gcacttgatg ttgtaggcgg ctgcaacatt 1150801 caattcgcgc ttgatccatt cagcaagcaa tattacgtca ttgaagtgaa tccgcgtgta 1150861 agccggtcat cggctctcgc atctaaagcg accggttatc cgattgcgaa gatggccgcg 1150921 aaactggcag tcggatacac tcttgacgag ctgaaaaatc cgctcacagg ctcgacttac 1150981 gcaagctttg aaccggcact ggattatgtg atcgtcaaat ttccgcgctg gccgtttgat 1151041 aaattcaaaa acgcagaccg caagcttggc acaaaaatga aagccaccgg tgaagtgatg 1151101 gcgattgaac ggaatttaga agcggcgata caaaaggcag ccgcgtcgct tgaattaaaa 1151161 aatatcggga cacaccttcc agagctcagc gggttgtcaa ttgatacgct atgggatttg 1151221 gcaatcactc cggatgaccg cagatttttc gttgtcatgg agctgttgag ccgcagcgtc 1151281 tcgattgatg acatccatga aaaaacaaaa attgatccgt ttttccttca tacctttgac 1151341 aacatcatca aattggaaaa ccgcctgatg gaagcaggga gcgatctctc ttttgaatta 1151401 ttgaagaaag caaaggaaaa gggattctca gacgcaacga ttgcctcgct gatcagcaaa 1151461 acagaagaag aggtgcgcgc gcttcgcaag gagatgggca ttacgccttc ctttaaaatc 1151521 gtagatacat gcgcggcaga gtttgatgcg aaaacaaact atttttactc cacatatttc 1151581 ggagagaccg atggagacat cagccgcaaa gagaaaaaac gcgcgctcat tatcggatca 1151641 ggcccgattc ggatcggcca aggcgttgaa tttgattaca gtgctgttca cggtgtgctg 1151701 acactgcaag agcttgggtt cgaaaccatc atgattaaca ataacccgga aactgtcagc 1151761 accgattatg aaattgcgga ccgcctgtat tttgaaccga tgacaacgga gcatattgta 1151821 aacgtggcgg agcaggaaaa tattgatttt gcaattgtgc aatttggcgg tcaaactgca 1151881 atcaatgctg ctgaagcgct cgaaaaagcc ggcattactc ttcttggcac atcatttcaa 1151941 acgctcgacg tgttagagga tcgggatcaa ttttatcagc ttcttgacga gctgggattg 1152001 aagcacgcaa aaggagaaat tgcttataca aaagaagaag ccgcttcaaa agcgagtgag 1152061 atcggctatc cggtgttaat ccgcccatct tacgttatcg gcggaatggg catgatcatt 1152121 gttgactcgc aagcccagct ttctcagctg ctgaatgatg aggacagcat gccatacccg 1152181 attttaattg atcagtatgt gtctggaaag gaagtcgaaa ttgatttgat ttccgacggc 1152241 gaggaagtct ttatcccgac atataccgag catattgaac gggcaggtgt ccattcaggg 1152301 gacagttttg ccattcttcc cggaccgtcc atcacgagcg ggctgcagca gggcatgaaa 1152361 gatgcggcac aaaaaattgc ccgaaaactt tcatttaaag gcatcatgaa cattcaattt 1152421 gtgatcgaca atggaaacat actcgttctt gaagtgaatc cgagagcgag ccgcacggtt 1152481 cctgtcgtca gcaaagtaat gggcgttccg atgattccgc tcgccacacg tctgctggcg 1152541 ggagcgtcct taaaagatct aaatccggca gttcaaaatc atcatggagt tgccgtgaag 1152601 ttccctgttt tttcttctca tgcgatccag gatgtggatg tcaagcttgg accggaaatg 1152661 aaatcaacgg gagaaggcat gtgtgtcgca tatgattcta acagcgcctt gaaaaaaatc 1152721 tatacaagag tctggagtca aaaaggaagc atttatttgc aaaacgttcc ggaagatgtg 1152781 aaggagttag cagaaaacgc aggttttaca atacatgaag gaacatttgc ctcatggatg 1152841 gaacaggaag gaaactcgct ccacattaat ctgagcggtt ctgaagaagc acgcaaagaa 1152901 cgtttggaag ccatgacgca cggcatcccc gtctttacag aagaagaaac tgtgcgggcg 1152961 tttttacaaa gcggttcagg ccatccgcag cctgtatctc tcaaagacct ctataaaaag 1153021 gaagtggcat catgcacaca gtgacgcaaa ccagtttata cggaaaagat ttattaacgt 1153081 taaaggacct tagtgaagaa gatataaacg ccttgctcgc agaagccggt gagctgaaac 1153141 aaaacaaaat tcagcctata ttccatggca aaaccttggc gatgattttt gaaaaatcat 1153201 caacgcggac ccgtgtttca tttgaagcgg gcatggcgca gctgggcggg agcgccctct 1153261 ttctaagcca gaaagatctg cagctggggc gcggtgagac tgtcgctgat acggcaaaag 1153321 tgctgtcagg ctatgtggat gccatcatga tccggacctt tgaacatgaa aaggtggagg 1153381 aacttgccaa agaagctgac attccggtga tcaatggact taccgataaa taccacccat 1153441 gccaggcgct ggcggatctc ttgacgatta aggagataaa agggaagctt aaaggcgtaa 1153501 aagtcgcgta catcggtgac ggaaataacg tggcgcactc cttgatgatc ggctgcgcga 1153561 aaatgggctg tgatatctcg atcgcttcac caaagggata tgaagtgtta gatgaagcag 1153621 ctgaagcggc aaagacatat gcacttcaat ccggctcttc tgtcacgctg acagatgatc 1153681 cgattgaagc tgtaaaagac gcggacgtga tttattctga tgtgtttaca agcatggggc 1153741 aggaagcgga agagcaagaa cgtcttgctg tctttgcgcc ttatcaggtg aatgcggcgc 1153801 tggtcagcca tgccaagcct gactatacat ttttacattg tctccctgcg catcgcgagg 1153861 aagaagtgac tgcggagatt attgacgggc cgaactctgc agtgttccag caggcggaaa 1153921 accgtcttca tgtgcaaaaa gcactgctga aggccatttt atataaaggg gaatcatcaa 1153981 aaaactgctg agccaaactc agcagttttt ttgatggcaa catattcaca gccgcttagg 1154041 cgcatactac agcaaaaagg aaaaggagga aaaacagtgg gacagcagca ccaattccgg 1154101 cccggacaga aagcgcctaa taacggtgtc tacgtagaaa tcggcgagac agggagcatg 1154161 gttaaaaacc ctcaaaaggt ccatctgtca gcaggggaaa tgttccccga aacatcaaac 1154221 cacaaccggc tgtggaccta caaaagaaag ccgtgaccac taaaaaaccc aaaacaataa 1154281 atgttttggg tttttggctt tttaatgctg gcttgcattt ttgttcatag gcatgatttc 1154341 tgctaaaacc atgattaaga catacagtac aacagcaatg acagatgatg ttttgaaatt 1154401 atacgtaacg ctgttcatgc ttgcaaccaa gtagcatgcc atatgtgata aaaggaacgt 1154461 ccaaataaag gcaataatat atcgcacgtt tccacctcgt ccttctcatt ctattctaaa 1154521 agttatcata ccatacaaaa agcgaagggg gaatccaatt ttagcagaaa gtgaggtgac 1154581 aaaagagtct gattcgtcac actttaatgg taaaatataa aacgtcaatc agtataatag 1154641 ccaaaaatgt aaaaggctag gactttacct tattcgtttc ttttctattt acataagata 1154701 gcgtgagatg aagtgtgaaa ggaggcgggc aagcgatggg aataacggaa agatactttc 1154761 aactgggaac ggagcataat gtcattcatc tgccctatcg cccgaacggc ttcggcatct 1154821 ttatcttggg ggacagaacc cactttgtcg gacatgattc aagcttttgg cagcagcatt 1154881 atggcagaaa tcagcttctg agcatgttga tgaatgaagg atacactctt tttaacagca 1154941 atctgttcgg aaggcattgg ggggcggaaa aagcagtcac ctatgccaaa cagctgatac 1155001 attctgtgct gaagcaggaa atcctcaatc cgaagattca tattttagca gaaggcatgg 1155061 gtgctctcgt ggccgatgaa ctgcttcgtt tttccccgga tcatatccgc tcagccgcaa 1155121 tgttgaatcc ttgtctcgat cttcaggcac attatgaatc ggaaaaagaa aataaatttt 1155181 tctataagca atttttgaaa gaagtatcga aaagctacgg aatttctgaa aaagaagcgg 1155241 aagcgattcg ttataaaaca attcaaagct acccgagcgg cgtaccggtt catatatggc 1155301 agcgtatgac cggagctcca tatccctaca gcgtacatgc ggaagttttc aaggaaaaac 1155361 agcaaaagca aggctcaccg gtcgacatga catttcattt atttgagcat ccaagcagaa 1155421 tttatgcatc aatttgcaaa ttctttcata gtcatgaaaa agaattatag agaatataat 1155481 gacaacagcc ttctcttttg cggaggctgt tttgttttgg gaaatgaaaa accggaaggg 1155541 cggcagatgc aatggaatca acgctgattg taggtgcgga cgaatttttc ggcctttcat 1155601 tatgtgagcg aatgatggat gaaggcatac atgttgacgt tgttctggcg gaaacagaag 1155661 ataaaatgag acaaatgtac ttagaagaaa gactcatgtg gcttgggaga aatgaactct 1155721 ttcgccagct tgaacacatt ggagaccaaa attatgatac aatttgtatc cagttcggaa 1155781 gttttttgcc tttagaccaa tatgattctc cttatatttt agtatatgaa gaagaccgaa 1155841 aagaatggga taaacgtgaa aaaacaggct cggaaaaaac cgtgatcctg ccgaaaatgt 1155901 acgggccatg gaaagaagaa acagaggaag acggctatta cacaaacgac gtggctgacg 1155961 agttgctgag attcctgtta gaaccaagcc gtcatagcaa agatcagctt tttgaattgc 1156021 aagtcacaga gaaaacctca aaagaagaag caaaaacaaa aattatcgag tggaaaagac 1156081 aattttcatc aattttcgac aaatattaag aaaaaccttc catgtttcga gttttctaga 1156141 tacaataaac gtataaaaat aatacatgtt atagcttgtc aaaaggagtt gaacatgact 1156201 tgatcacaag gcttgtcatg atcttttctg tcctcctttt attgagtgga tgtggacaaa 1156261 ctccgttcaa aggaaaaatt gagaaggtcg gcatgctctt tcctgatacg attaatgacc 1156321 tcgtatgggg cacaaaaggg tataaaggat tactgaatat acaatccaaa tacaatgtgg 1156381 acgtctatta taaagaaggc gttaaaacag aagaagatat cataaatgcg attgaggatt 1156441 ttcataagag gggcgtcaat ctgctctacg gccatgggag tgaatatgct gaggtgttta 1156501 acttggtcgg cgaagattat ccagatatgg aattcgtcat ttccaatgcg aaagcgaaag 1156561 ctgataatgt aacaagtgtc cattttagcg gggaagcaat gggctttttt ggaggaatga 1156621 ctgctgccca tatgtcgaaa acgaatcagg tcggtgtaat tgcttccttt acgtggcagc 1156681 ctgaggttga cggttttatc aaaggggcca agtatgaaaa tccggatata gaggtaaata 1156741 cgaaatatac ggatcattgg gatgatgata caacagcagt aaagctttat cagaaaatga 1156801 agaacgaagg cgcggatgtt gtgtatcccg ccggagacgg gtataatgtt cctgttattc 1156861 agcaaatcaa aaaagacggt ctttatgcca taggctacgt cacagatcaa tcggatctgg 1156921 gcgagaatac cgtattaacc agcacggtgc aaaatgtgga caaggcctat gaaatcattg 1156981 ctgaacaatt taataaaggc acccttgagg gcggcgatca ttactacgac ctgaacacgg 1157041 gagtcgttga gatgggaaca ttcagcccgc tcgtcgatca agactttcag caaagaatcg 1157101 ccaagctgat caaaacatac aacaaaacag gcgagctgcc aaaaaacgag taatggagtg 1157161 acgtcacatg cagcacgaaa aatcacttga attcttgcaa attgccatga aatatctccc 1157221 tgaagcgaaa gaacagcttg agaaatcagg cattgagctc tcaatggagg ccatccagcc 1157281 gtttatgaat ctatttacaa cggtaatggc ggaagcttat gagcttggca agtctgacgc 1157341 taaatctgaa acagaataag aagaagccac ttttttgaaa gtggcttttc acatgatttt 1157401 ctttttaata gcggagagca tgggcgcaag ctcctttaaa gcgggcttga tttgatcaag 1157461 agagttcata attgaaccga tttggtccat aatatgcatg taattaatcg tctcttcgtc 1157521 gtttgtctga gaaacctgag aaacttcctc ttgctgttcc tcctccttct cttctgttgg 1157581 ttttgctgca tcgccgaaca tcattcttga aaacacatcc aactgcatac gcctcctttc 1157641 catataccat actctatgag taagatgaac tgatagttta gacgaatata ttgccatgtg 1157701 aaaaaaaata ggatagaatt agtacctgat actaataatt gatcacaacc tgattgatct 1157761 tctaaattta agatataaag gagtcttccc taatgaaagc tggaatactt ggtgttggac 1157821 gttacattcc tgagaaggtt ttaacaaatc atgatcttga aaaaatggtt gaaacttctg 1157881 acgagtggat tcgtacaaga acaggaatag aagaaagaag aatcgcagca gatgatgtgt 1157941 tttcatcaca tatggctgtt gcagcagcga aaaatgcgct ggaacaagct gaagtggctg 1158001 ctgaggatct ggatatgatc ttggttgcaa ctgttacacc tgatcagtca ttccctacgg 1158061 tctcttgtat gattcaagaa caactcggcg cgaagaaagc gtgtgctatg gatatcagcg 1158121 cggcttgtgc gggcttcatg tacggggttg taaccggtaa acaatttatt gaatccggaa 1158181 cctacaagca tgttctagtt gttggtgtag agaagctctc aagcattacc gactgggaag 1158241 accgcaatac agccgttctg tttggagacg gagcaggcgc tgcggtagtc gggccagtca 1158301 gtgatgacag aggaatcctt tcatttgaac taggagccga cggcacaggc ggtcagcact 1158361 tgtatctgaa tgaaaaacga catacaatca tgaatggacg agaagttttc aaatttgcag 1158421 tccgccaaat gggagaatca tgcgtaaatg tcattgaaaa agccggactt tcaaaagagg 1158481 atgtcgactt tttgattccg catcaggcga acatccgtat catggaagct gctcgcgagc 1158541 gtttagagct tcctgtcgaa aagatgtcta aaactgttca taaatatgga aatacttctg 1158601 ccgcatccat tccgatctct cttgtagaag aattggaagc cggtaaaatc aaagacggcg 1158661 atgtggtcgt tatggtaggg ttcggcggag gactaacatg gggcgccatt gcaatccgct 1158721 ggggccgata aaaaaaggtg aggtgcacac aagatgacta aaaaaagagt agttgttaca 1158781 ggacttggag cattatctcc acttggcaac gacgtcgata caagttggaa taacgcaatc 1158841 aacggtgtgt ccggaatcgg tccgatcact cgtgttgacg ctgaagaata tccggcaaaa 1158901 gttgccgctg aattaaaaga ttttaatgtt gaagattata tggataaaaa agaagccaga 1158961 aaaatggacc gctttacaca atatgcggtt gtggctgcga aaatggcggt tgaagatgca 1159021 gatcttaaca ttaccgatga gatcgcgccg agagtcggtg tttgggtagg ctccggtatc 1159081 ggaggacttg aaacactaga gtctcaattt gaaatcttct taacaaaagg cccaagacgg 1159141 gtaagcccgt ttttcgtgcc aatgatgatt cctgacatgg cgacaggcca gatttctatt 1159201 gcattaggag caaaaggggt gaactcttgt acggttacag catgtgctac aggaacgaac 1159261 tccatcggtg acgcgtttaa ggttattcag cgcggtgatg cagacgtgat ggtcacaggc 1159321 ggaacagaag cgccgctgac aagaatgtca ttcgccggct ttagtgccaa caaagcgctg 1159381 tctactaatc cagatccgaa aacagcgagc cgcccgtttg ataaaaaccg tgatggcttt 1159441 gtcatggggg aaggtgcagg gattatcgtt cttgaagaac ttgagcatgc cctggcccgc 1159501 ggcgctaaaa tttacggaga aattgtcggc tacggctcaa ccggagacgc ttatcatatc 1159561 acagcgccgg cccaagacgg tgaaggcgga gcgagagcga tgcaagaagc cattaaagat 1159621 gcaggcattg cacctgaaga aattgattac atcaatgctc acgggacaag cacgtattac 1159681 aacgacaaat acgaaacaat ggcgattaag accgtttttg gcgagcatgc gcataaactt 1159741 gcggtaagct ctacaaaatc gatgacaggc cacctcttag gagcagccgg cggtattgaa 1159801 gccattttct ctatcctggc cattaaagaa ggcgtgattc cgccgacaat caatattcaa 1159861 acacctgacg aagaatgtga tttggattat gtgcctgatg aagcccgcag acaggaactt 1159921 aattatgttc tcagcaactc attaggattc ggcggacaca acgcaacatt aatctttaaa 1159981 aaatatcaat cataatcaag ccaaaccggc tgcccttaaa gggtagccgg ttttttttgt 1160041 gtgcatagga ttaaaagagg aggcgatcac atgagtgtag aacaaacata tagctggctc 1160101 aggaaggccg gttcaataga tgatttggcg cattacatta tcccgctttt ttcaggtgcg 1160161 gagaaaaaga actggaaggg cattctgggg catcttcagc atcatgggat gtttaaaaac 1160221 ataaaagagg gtattcagac ggtttccaag ctgaaggaaa aaggttttta cggacatatc 1160281 caaaaggaag aacagtacct caaaaacaaa tggcaaggtc ctgatgtacc aattgttacg 1160341 ctgccggttg atgaacgaaa caggagaatc cgtttagaat tcggatcaaa atcaggactc 1160401 gcctttcaag acaaaatgtt cctttttctt tcgtcagatt tagattttgg gtcggtatct 1160461 gcccttatga cgcatgagta tcatcacgtt tgccggttag gtcatctgac aaaagaggaa 1160521 aaggatgtca cattacttga tacaatcatc atggaagggc tggcggaata tgctgtttat 1160581 gagaggttcg gccgaagtca aacggctgaa tggacgactt ggtatacacc ggaacagctt 1160641 caggctttat atgaaaaaaa gattgcgccc catcgggata tcaaacggga taatcgatta 1160701 tttccccagc tgttattcgg caaaggatat cagccaaaaa tgcttggata cgcagttgga 1160761 ttcaatattg taaaaaaata tttaaccgcc agcaaggcaa gcaccgcaga cgggctgtcc 1160821 attcctgctg agaccttttt ggatgcaatg ctttaaaagg ataaaataat ggaatttcat 1160881 taataatatt acatttatcc taaaaaattc ttgattttgc aaaatgattg taataatata 1160941 caactataaa atttttcgat aattcaatat tatttattat ttctgaataa agggattgct 1161001 ttctcttgaa aacgtttgac aacaagaggg gggaaagggg agctagcatg agcacacttt 1161061 tagaagtgaa taatttaaag acttattttt tcaggaaaaa ggagccgatc cctgcggttg 1161121 acggagtcga ttttcacatc agcaaaggcg aaaccgtcgc gcttgtaggt gaatcgggct 1161181 ccggaaaaag cattacttct ttatcaatta tgggcctcgt ccaaagctca ggcggaaaaa 1161241 tcatggacgg ctctattaaa ctcgaagaca aagacctcac ctcattcact gaaaacgatt 1161301 attgcaaaat ccgcggtaac gaagtatcca tgatctttca ggaaccaatg acctccctta 1161361 atccggtgtt aacaatcgga gaacaaatta ccgaagtgct gatttaccat aaaaacatga 1161421 agaaaaaaga agcccgtcaa cgagctgttg aactcttgca gatggtcggt ttctcccggg 1161481 cggagcaaat tatgaaggag tacccgcatc ggctgtccgg cggtatgaga cagagggtga 1161541 tgattgccat cgcactgagc tgtaatccta aactgctcat tgctgatgaa ccaacgacag 1161601 cgctggacgt gacaatacaa gcccaggtgc tggagctcat gaaagatctc tgtcagaagt 1161661 tcaatacatc gattcttctc atcacacacg acttaggtgt cgtgtctgaa gctgccgata 1161721 gagtgattgt catgtactgc ggacaagtcg tagaaaacgc cactgttgat gacttatttt 1161781 tagaaccgct tcatccgtat acagaaggcc tgcttacgtc aattcctgtt atagatggag 1161841 agattgataa attaaatgcg attaaaggca gtgtgcctac accggataat ctgccgccgg 1161901 ggtgccgttt tgccccaagg tgcccgaaag ctatggataa gtgctggaca aatcagcctt 1161961 cgcttttgac acacaaaagc ggaagaacgg tgagatgctt tttatatgag gaagagggtg 1162021 ccgaacaatc atgacagcag ctaatcaaga aacaatctta gagcttcgtg acgtaaaaaa 1162081 atactttccg atccggtcag gcctttttca aagaaaagtc ggtgatgtaa aagcggtgga 1162141 tggtgtttca ttttcgttaa aaaaaggaga aacactcgga atcgttggag agtcgggctg 1162201 cggaaaatcg actgccggca gaacgatgat cagactgtac aaaccgacag agggccaaat 1162261 tctttttaaa gggcaggata tttccaatct gtcagaggag aagctgcgga agagtgtccg 1162321 caaaaatatt caaatggttt tccaagatcc atttgcttcg ttaaacccga gaaagaccct 1162381 gcgttccatc ataaaggagc cgtttaatac gcacaacatg tataccatgc gtgaacgaaa 1162441 cgaaaaagtt gaagagctgc ttgcaagagt agggcttcac ccgtcgtttg ccggccgtta 1162501 tccccatgag ttttcaggcg gccagcgtca gcggatcggc attgccagag cactcacttt 1162561 gaatccagag ctgatcattg cagatgagcc ggtttccgca cttgatgtat ccattcaggc 1162621 ccaagtgatt aacttgatgg aggaattaca ggaagaattt aatcttacgt atctatttat 1162681 ctctcatgat ctgagtgtcg tccgccatat cagcgacaga gtcggagtaa tgtatcttgg 1162741 caaaatgatg gaactgaccg gcaagcatga gctttatgac aacccgcttc acccatatac 1162801 ccaagcgctt ttatcctccg ttccggttac aagaaaaaga ggttctgtca aacgtgaacg 1162861 cattgtcctg aagggagaac tgcctagtcc ggccaacccg ccaaaaggct gcgtattcca 1162921 cacaagatgt cctgttgcaa aaccgatatg caaggaacaa ataccagaat ttaaagaagc 1162981 tgctcccagc cactttgtgg cttgtcacct ttatagctaa tgttgcccgc acagctttga 1163041 gagggggtat gcacactaca taaacaacag cctagaagaa cgaacatttc aagaggggga 1163101 atatctaatg aaaagacgga aaaccgcact gatgatgcta agtgtattga tggttctggc 1163161 catcttttta tcagcctgct cgggatcaaa atcaagcaac agcagcgcga aaaaatcagc 1163221 aggcaaaccg cagcaaggcg gggatttggt tgttggttca atcggagaac ccacactttt 1163281 taactctctg tattctaccg atgacgcaag tacggatatt gaaaatatgc tgtacagctt 1163341 tttaacgaaa acggatgaaa aactaaatgt gaaattgtca ctcgctgaaa gcattaaaga 1163401 attagacggc ggccttgcat atgatgtgaa aattaaaaaa ggcgttaagt ttcatgacgg 1163461 aaaagaactg actgcagacg acgtcgtatt tacgtacagt gtccctttaa gcaaagatta 1163521 caagggagaa cgcggttcaa catatgaaat gctgaaatcc gtagaaaaaa aggcgattac 1163581 gaagtcttgt ttaagctgaa atataaagac ggtaatttct acaacaatgc gttagacagc 1163641 acagctattc tgccgaaaca tattctcggt aatgttccga ttgctgattt agaagaaaat 1163701 gagtttaaca gaaagaaacc aatcggttca ggaccattta agtttaagga atggaagcag 1163761 ggccaatata ttaagctcga agcgaatgat gattactttg aaggaagacc gtatttagat 1163821 actgtgacgt ataaagtcat tcctgacgca aatgctgccg ttgctcagct gcaggcaggc 1163881 gatattaatt tctttaatgt gcccgccact gactacaaaa cggctgaaaa attcaacaac 1163941 ctaaaaatcg ttactgattt ggcattaagt tatgtgtaca tcgggtggaa tgaaaaaaat 1164001 gaattattca aggataaaaa ggttcgtcaa gcgctaacaa ccgctcttga ccgcgagtca 1164061 atcgtcagcc aagtattaga tggagacggc gaggtagctt acattccgga aagcccttta 1164121 tcttggaact atcctaaaga tatagatgtt ccgaaatttg agtacaacga gaaaaaagcg 1164181 aaacagatgc ttgcagaagc cggctggaaa gatacgaacg gtgacggcat tctggataaa 1164241 gacggaaaga aattctcgtt tacccttaaa acgaaccaag gaaacaaagt ccgtgaagac 1164301 atcgctgtcg tcgttcagga acagctgaaa aaaatcggca ttgaagtgaa aacccagatc 1164361 gttgaatgga gcgctctcgt tgaacaaatg aatcctccga attgggattt tgatgcaatg 1164421 gtcatgggat ggagtttatc cacattcccg gatcaatatg atattttcca ttcaagccag 1164481 attaaaaagg gtttgaacta cgtttggtat aaaaatgccg aagcggataa actcatgaaa 1164541 gatgcaaaat caatcagtga cagaaagcag tattcaaaag aatatgagca aatctatcaa 1164601 aaaattgcgg aagatcagcc gtatacgttc ttgtattatc ctaacaacca tatggcaatg 1164661 ccggaaaatc ttgaaggata caaatatcat ccgaaacgtg atttgtataa tattgaaaaa 1164721 tggtggcttg caaaataaat ttcccttaaa ggggagggag agcgttttct ccctcttctg 1164781 tttttaataa ggaaagtaaa gggggacaag tatatggctg catatattat cagaagaacc 1164841 ttaatgtcta tcccgatttt attgggaatt acgattttat catttgttat catgaaagcc 1164901 gcgcccggag atccgatgac attaatgatg gacccgaaaa tcagccaggc tgacagagag 1164961 cagtttattg aaaaatacgg tctgaatgat cctcagtacg ttcaatattt aaagtggcta 1165021 ggcaacatgg tgcagggtga tttcggaacg tctattgtca gaaaaggaac gcctgtttca 1165081 gaattgatta tggcaagact acccaatacg ctcctgctga tgctggtttc aacgattttg 1165141 gctcttatga tttctattcc gttcggtgtc ctgtcggcaa agcggccgta ttcaaaaatc 1165201 gactatggca ttacatttac ctcgtttata ggcctggcta ttccaaactt ttggtttgga 1165261 ttaattttga ttatggtgtt atcggtaaat ctcggctggt ttccaactgg gggtgtcgag 1165321 acactgaata ccgaattcaa tatatttgac cggattcatc atttaattct gcctgcattc 1165381 gttctagcta cagctgacat ggccggactg acgagataca cgagatccaa tatgcttgat 1165441 gtattaaatc aagattatat tcgcacagcg agagcaaaag gatttaaaga gaacagagtg 1165501 ctatttaaac atggattgag gaatgcatta ttacccgtca ttacaatttt cggtttgatg 1165561 attccttcat ttatcggcgg atctgtcgtt gtcgaacaaa ttttcacttg gccgggatta 1165621 ggaaagctgt ttgtcgattc agcattccag cgcgattatc cggttatcat ggcaatgact 1165681 gtgatctcgg cggttcttgt cgttgtcgga aacctcattg cagacatcct ttacgcgatt 1165741 gttgatccgc ggatcgaata ttaaaaggag ggaaacagag atgtcagagc tgcaaacaac 1165801 tccctcgccg gagatcaggc tgaaagaaaa tatttcgaaa aagccagaaa caatgacaaa 1165861 gattttctgg gaaaaattct cgaaaaacaa actggccatt ttaggtgccg ttattctttt 1165921 tatcattatt atgtctgctg ttttcgcccc tttaattgca ccttatcccc aagagcagca 1165981 aagcctgctt gataaatata aggcgccggg ccttgaacat ctgatgggaa cggataaatt 1166041 tggacgtgat attttcagcc ggatcctata tggagcgcgt gtctctttat tggttggatt 1166101 tgcgtccgta gtcggttcga ttttgatcgg aacggtttta ggagcattag ccggatattt 1166161 cagaggaata gtggatgctg tcattatgcg tgtagttgac attgtgttat ccattcctga 1166221 tattttcttg ttgatcacgc tggtcaccat cttcaagccg ggtgtggaca aattgatttt 1166281 aattttctgt ctcacaggat ggaccacaac agcacgatta gtaaggggag aattcttgtc 1166341 gctccgttca agggaatatg ttcttgctgc taaaacaatt ggaacaaaaa cgcacaaaat 1166401 tattttttct catatcctgc ccaatgcgtt agggccgatt atcgtgtcag ctacgctgaa 1166461 agttgggtct gttattctag ctgaatcggc gctaagctac ttgggctttg gaatccagcc 1166521 gccaatcgct agctggggga acatgcttca agacgcacag aatttcacag taatgattca 1166581 agcatggtgg tacccgttat ttcccgggct atttatttta atgaccgttt tatgcttcaa 1166641 ctttgtcggt gatggcctgc gggatgcgct tgacccgaaa aatattaaat aaaaatgaat 1166701 atcatatctg ttataaaata tcaccaaatc agaaaaaagc aggtctcctt tagtcagaaa 1166761 atatacaaag agatctgctt tttatgattc ttacataaac ccagtgattc cagatttcct 1166821 caatctcttt ggaataattt ctctatccct tgcctatact gtggacaaca gtttttataa 1166881 aagtgagggg ttagagatgt tatttcttca tgatgtgtgg gtcaattggt ttgaagggga 1166941 agaaaatggc tacaatgtat gccactttca cgaatggcgc aaggaagata cggttgagct 1167001 tttggatcag gtgccgctgt taagggtgcc gtcagtactg tttcattaca tagaaaacga 1167061 tttgtcagag cttccgaaag gtttgcttga agacgtacat cagaaatcgt acattcgaaa 1167121 aaatcatgag cggacaaagc ttgagtattg ttttgtcgta acagacggaa tcggcatttt 1167181 agctgttgac acgatcggct acacgatccc tgtcagaaaa agccgtctaa tcccaagaca 1167241 ggagcagctc gtttatgaaa tggtaaaaga tgtagagcct gaaacatatg aatttgagcc 1167301 aaagaagctg gaatcctcca aggaatatca catcttatca ttagcaccag aacatgtcag 1167361 aggactgaca agaaaagaac ggcaaattaa gcagctgatg tttatggcgc ttgaccaatt 1167421 aaaagggctg aaaaaccgag cggaaattgg ctactggtac acagagtgga atccgcatat 1167481 gtatgaacaa atcaaaagga tgagctttga agagatttgg gacatgctgt ataacgaaac 1167541 aattgaaggc tggtcggaca aacacctagc tttttgcgaa aacctaataa aaggacagcc 1167601 ttttttcgaa aagctttggg aaatggaaaa cgaatcaaag gtcaactgaa aaaaaccgct 1167661 ctttgcaaag agcggttttt tgattagcgt ctttttcttc caagacccat ggcattctcc 1167721 atttttttca gcattttgtt tgctgtccga ttcgctcgtt ccgcgccttc atcaagaatc 1167781 cggtctaatt cttcagattc tatcagctcg taatagcggt cctggatcgg ttttaatgcg 1167841 ttcactacga cttctgccaa atcaccttta aactcgccgt agccttttcc ttcgtacttt 1167901 gcttcaagct cttcaattgt cgtattgccg aggattgaat aaattgtaag aaggttggaa 1167961 acgcccggtt tgttttcctt atcaaatttg acaatgcctt cagaatccgt tactgcgctt 1168021 ttgattttct tttcaagctg cttcggctca tccagcaatg taatataagc tttctgattc 1168081 ggatcagatt tgctcatttt cttcagcgga tcattcagag acatgatacg tgcaccgact 1168141 tttggaattt tcacttccgg aatcgtaaag atgtcgttgt attttttgtt gaagcgttct 1168201 gcaagattcc gcgtcagctc aaggtgctgc ttttgatcct cgccgacagg tacaagatcc 1168261 gttccgtaca gcagaatatc agcggccatc agcggcggat atgttaacag gccggagacg 1168321 acagcttcat tgcctttgga tttgtcctta aattgagtca tccgctcaag ctcgccgata 1168381 taggcgacac actgcatcat ccatccggcc tgcgcatgtg cggggacctc tgactgaata 1168441 aacaatgttg ctttttctgg atcaagtccg acagctaagt aaagcgccgc gagattgcgg 1168501 atattctttc taagctcaag ccggtcttga ggaacagtta tcgcatgctg atcgacgatg 1168561 caaaaatagc tgttataatc atgctgcagt tcgacaaact gcttcattgc accgatatag 1168621 ttgccgagcg tcactgagcc gcttggctga atgcctgaaa aaatcgtttg tttcatgaaa 1168681 acatcaacct catttcttaa aacataataa aaaaggctca ttcttcccct gtaaaaaagg 1168741 gacgaatgaa ccgtggtacc accctgatta ttccattaaa atggaatcac tctgacgttt 1168801 gtaacggaga ctgctccggc tgagcctact tttttccagt tcggtcagct gctccaaagt 1168861 ccattccaca ttgcccgtta tctgctccca gcaccgcaga ctctcttcaa acaggtgaaa 1168921 cgtgtactac tctttttcat agcaagcttt tcttttgatt gcttcattat aaatcaatta 1168981 taaccaattg tcatcatgaa aaaacattct tttttccagt aaaattgtaa taatataaat 1169041 aacacgagtg ctgtaaaatc cttaaatgat aactgctatc agcgtaaaaa caggcagata 1169101 ttatatgtaa aaagcaatat gggcagaaaa cacatgaaaa agtttttaat caatttatgc 1169161 tttaaatggt agaaggatat tatgttcatg gaagaaaaac taacgaagtt taaatatttt 1169221 aaattgataa aataatattg caataaatta tttgtttcat tataatgaac ttgttcactc 1169281 tattgttaca gcttttttac aaaaataatc agaaaagacg gaacagaata aaagttgtgg 1169341 aaactcaggt tcatttgtct gatatttctg aggatttagc cgtaaggagc tgaaaattat 1169401 tattaggggg tttgcgaata tgaaaaaacg ttggtcgatt gtcacgttga tgctcatttt 1169461 cactctcgtg ctgagcgcgt gcggctttgg cggcagcgga tcaaacggtg aagggaaaaa 1169521 ggacagtaaa ggaaagacga cacttaacat taatattaaa actgagccgt tctccttaca 1169581 tccgggattg gcaaatgatt cagtatcagg cggtgttatc cgtcagactt ttgaaggatt 1169641 gacacgtatc aatgcagatg gtgagcctga agaaggcatg gcttctaaaa ttgaaacgag 1169701 caaggacgga aagacatata catttaccat tcgtgatggt gtgaaatggt ctaatggaga 1169761 ccctgtaact gcacaagatt ttgaatatgc ttggaaatgg gcgcttgacc ctaataatga 1169821 atcacaatac gcttaccagc tctactacat aaaaggtgct gaagcggcga ataccggaaa 1169881 aggcagccta gacgatgtgg cagtaaaagc tgtgaatgac aaaacgctga aggttgaatt 1169941 aaataacccg actccatatt tcactgaatt aactgcgttc tatacgtata tgccgatcaa 1170001 taagaaaatt gcagagaaaa ataaaaagtg gaatacaaat gccggagatg attatgtatc 1170061 aaacgggccg ttcaaaatga cggcatggaa acacagcggc tctattactc tcgaaaaaaa 1170121 tgaccagtat tgggataaag acaaagtcaa actgaagaaa atcgatatgg ttatgatcaa 1170181 caataacaat acggaactaa aaaaattcca agctggcgaa cttgattggg ccggtatgcc 1170241 gctcggacag cttccgacag aatccctgcc gaccctgaaa aaagacggtt ctttacatgt 1170301 tgagccgatt gcaggagtgt attggtacaa attcaacact gaagctaagc cattagacaa 1170361 cgtcaatatc cgtaaagctt taacatattc gcttgaccgt cagtcgattg ttaaaaacgt 1170421 tacgcaagga gagcaaatcc cggcaatggc tgcagtgccg cctacaatga agggatttga 1170481 ggataacaaa gaaggatact tcaaagacaa tgatgtcaaa acagcaaaag aataccttga 1170541 aaaaggccta aaagaaatgg gcttaagcaa ggcatctgat ttgccaaaaa tcaaattgtc 1170601 ttacaacact gatgacgcac acgcgaaaat cgctcaagca gtacaagaaa tgtggaagaa 1170661 aaatttaggc gttgatgttg agcttgataa ctcagagtgg aatgtctata ttgataagct 1170721 ccacagccaa gattatcaaa tcggccgtat gggctggctc ggcgacttca atgatcctat 1170781 caacttcctt gaattgttcc gcgacaaaaa cggaggaaat aacgatacag gctgggaaaa 1170841 tccagaattc aaaaagcttc tgaatcagtc acaaactgaa acagataaaa caaaacgtgc 1170901 agagctgctg aaaaaagcag aaggtatttt cattgatgaa atgccggttg ccccaatcta 1170961 tttctatact gatacttggg tacaggatga aaacctaaaa ggtgttatca tgccaggtac 1171021 tggtgaggtt tatttcagaa acgcatattt taaataaggc tacgtctgaa aataaaagac 1171081 ctcaaggtat atggggagaa aagccccata tacctttctt actgatggag tataaaaatg 1171141 taaaaaccat ggaggtgttc ccccttgcta aaatatatcg gaagacgctt agtctatatg 1171201 attatcacac tatttgtgat tgtaactgtg acattcttct taatgcaagc agcaccgggc 1171261 gggccatttt caggtgagaa aaagcttccg cctgaaattg aagcaaattt aaatgcgcat 1171321 tatggcttgg acaagccgct gtttgtacaa tatgtcagtt atttgaaatc agttgcaatg 1171381 tgggatttcg gaccgtcatt taaatataaa ggtcagagtg ttaacgacct gatcagttca 1171441 ggtttccccg tttcatttac tcttggagca gaagctattc tcctcgcttt agcgttaggt 1171501 gtattgtttg gggtcattgc agccctttac cataataagt ggcaggatta taccgtcgcg 1171561 attttaacga tatttggtat ttcggttccg agctttatca tggcggctgt tctgcaatat 1171621 gtgttctcca tgaagcttgg gctgtttccg gtcgcggggt gggattcctg ggcatacacc 1171681 tttttgcctt ccatcgcact tgcttccatg ccgatggcgt ttattgccag actttcccgt 1171741 tcaagcatga tcgaagtgtt aaacagtgat tatatccgca cagcgaaagc gaaagggctt 1171801 tcccgcccag cggttacagt gcggcacgcc attcgaaacg cacttttgcc ggttgttaca 1171861 tatatgggcc cgatggccgc acaggtctta acggggagct tcattattga aaccattttt 1171921 gggattccgg ggcttggtgc acacttcgtc aacagtatta caaaccgtga ttatacggtc 1171981 attatgggtg taacggtgtt cttcagtgtc atcttgctat tgtgtgtatt aatcgtagat 1172041 gtgttatacg gcattattga tccaagaatc aagctttcca aagcaaagaa aggagcctag 1172101 gccatgcaga acattccaaa aaacatgttt gaaccagccg cagcgaatgc cggcgatgca 1172161 gaaaaaataa gtaaaaagag cctttccctc tggaaagatg cgatgcttcg cttccgcagc 1172221 aataagcttg caatggtcgg gcttatcatt atcgtactta ttatccttat ggcaattttt 1172281 gcgccgatgt tctcaaggta tgattattca actactaatc tcttaaatgc ggataagccg 1172341 ccttcaaaag atcactggtt cggaacagat gatcttggac gggacatttt cgtccgtaca 1172401 tgggtagggg cgcgaatctc aatctttatc ggtgttgcag ctgctgttct cgatttgctg 1172461 atcggcgtca tttgggggag catttcaggc ttccgcggag gaagaacaga tgaaatcatg 1172521 atgcgtatcg ctgatatcct ttgggcagtt ccttcattat taatggttat cttactgatg 1172581 gttgttcttc cgaaaggtct atttacgatt attattgcca tgacgattac aggctggatt 1172641 aatatggcca gaatcgtgcg cggacaagtg ctgcagctga agaatcagga gtatgtgctt 1172701 gcttcacaga cactgggtgc aaaaacatcc cgtcttctat ttaaacatat cgtgccaaac 1172761 gcaatgggtt ctattttggt cacgatgaca ctgacagttc ctactgcgat ttttacagaa 1172821 gcctttttaa gctatttggg acttggtgtt ccggctccgc tggcaagctg gggaacgatg 1172881 gcttctgacg gattgcctgc attgacctat tatccgtggc gtttattctt ccctgccgga 1172941 tttatctgca ttacaatgtt tggttttaac gttgtcggcg acggattaag agacgcattg 1173001 gatcctaagt tacgtaaata agggagtgat acgggtgaca cgcctattag aagtaaaaga 1173061 tttagcaatt tcatttaaaa catatggcgg agaggtccag gcgatccgcg gagtgaattt 1173121 ccatctggat aaaggggaga cgctggccat tgttggagaa tcaggttccg gaaaaagtgt 1173181 aacctctcaa gcgattatga agctgattcc aatgcctccg ggttatttca aacgcggtga 1173241 gatcctgttt gaaggaaagg atctggtgcc gctgtccgaa aaagaaatgc aaaatgtccg 1173301 gggaaaagag atcggcatga tattccaaga tccgatgacc tctttaaatc caacgatgaa 1173361 ggtcggtaaa caaattacgg aagtgctttt taaacacgaa aagatctcga aggaagcggc 1173421 taaaaaacgc gcggttgaac tgctggaatt agtcggtatc ccaatgccgg aaaagcgggt 1173481 gaaccaattt ccgcatgaat tttcaggcgg gatgagacag agggttgtca ttgccatggc 1173541 gcttgcagcg aatccgaaac ttctgatcgc cgatgagccg acaactgctc ttgatgtaac 1173601 gattcaagcg caaattttgg aattaatgaa ggatttgcaa aagaaaattg acacgtccat 1173661 catctttatc acacacgatc ttggtgttgt ggctaacgtt gctgaccggg tcgctgtcat 1173721 gtacgcggga cagattgtag aaactggtac ggtagacgaa atcttctacg acccgagaca 1173781 tccgtacact tgggggcttc ttgcatccat gccgacactg gaaagttcag gagaggaaga 1173841 gctgactgca attccgggca cgccgcctga tttgacaaac ccgccaaaag gagatgcttt 1173901 tgccctgcgg agctcttacg cgatgaaaat cgattttgaa caggagccgc caatgtttaa 1173961 ggtatccgat actcattatg taaaatcgtg gctgcttcat cctgacgcgc caaaggtaga 1174021 gccgcctgaa gcggtaaaag cgaaaatgcg taaactggca aacacgtttg aaaaacctgt 1174081 cttagtgaga gaagttgaat gaattgactg aaaaactatt agaaatcaaa catttaaaac 1174141 agcactttgt cacgccgagg ggaacggtta aggctgtaga tgatttatca tttgatatct 1174201 ataaaggtga aacattaggg ctggttggtg aatctggctg cggtaaatcg acaacaggcc 1174261 gaagcattat caggctgtac gaagcaaccg atggtgaggt gctgttcaac ggcgaaaatg 1174321 tgcacgggag aaaatcgcgg aaaaagctgc tggaattcaa ccgcaaaatg cagatgattt 1174381 tccaagaccc ctatgcatcc ctgaatccga gaatgacagt tgctgatatt attgctgaag 1174441 gccttgatat tcataagctg gcaaaaacga aaaaagagcg gatgcagcga gttcatgaac 1174501 tattggaaac agtgggattg aacaaggaac acgcgaaccg ctatcctcat gaattttccg 1174561 gcggccagcg ccaaagaatc gggattgcca gagcgcttgc tgttgatccg gaattcatta 1174621 tcgcggatga gccgatttcc gctttggatg tatccattca agcgcaggtc gtgaatttaa 1174681 tgaaagaact gcaaaaagaa aaagggctca catacctgtt tattgcccac gatttatcga 1174741 tggtcaaata catcagtgac cgcattggcg tcatgtattt cgggaaactg gttgagcttg 1174801 cgccggcaga tgagctttat gaaaatccgc ttcacccata tacaaaatca ttgctttctg 1174861 cgattccgct tcctgatccg gactatgaga gaaatcgcgt tcgccagaaa tatgatccgt 1174921 ctgtccatca attaaaggat ggggaaacga tggaattccg tgaagtcaaa ccgggacatt 1174981 ttgtgatgtg cacggaagcc gaatttaaag ctttttcatg attcatcaat ccttcaagag 1175041 atttctcttg aaggattttt ttgcgtcttc atagaaagtg agaatgataa catttacaat 1175101 tagaggaaaa agcggaggcg aaatacgatt caatttctgc ataacaaaaa tgtttttgcg 1175161 ctattgctgt ctcaatcttt tcaatcttta gcaggagtcc tcgtcacaat cgttttaatg 1175221 gtccggatct atcaaatgac tgactccgtt tttttggcgg gccttatttt atcgttcatg 1175281 tcgtttgcga gtatagcagc aagcttttgc gtctctccgg tgcttcgcat tctcggtttt 1175341 aaaaaggtgc ttgcgggagc gaatctgctg agagcggtct ttattatact gatggcatac 1175401 agcgtcactc atcacggaca ggcattcttt tggattacgc tgctgtttgt gttttgtttt 1175461 tccttcgcgg gcgctttttt tcagccggca agatttgcgc tgctgccgat tattgttcca 1175521 aagaagcaat atgtaaaagc gaatggtgtg atctccctct cgaatcaatt gttcttaaca 1175581 gcaggctggg gccttggagg ccttctgacg tacgccgtcc cttttgaact cgttgtcggc 1175641 gctgccattt gcctgtttgt tctatcggga gcttccatca gtgtgctgca tgtaaatgaa 1175701 gaagaggctg caggaactgc tgaaacagca tctgtcagaa gtatatggaa ggatttaatg 1175761 atcatcccta ttgtaagaga cattactgta atggacatgt tagaagcttt ggcgggttcc 1175821 gtatggtcat ctgctattct cctcgcattt actgcggctg ttttgcatga aacagaggtg 1175881 tggtggggga tgtttaacgc ttcctatttt ataggcgcaa ttgtcggcag tgtgattgct 1175941 attcgttttt cttctttttt tgagcggaat atgggctatg ccattatgtt cagctcgctt 1176001 gtaatgtcgg cgctgaccct tttgttttca ttttctccag tcccattttt atgcgctctg 1176061 gcttgtgctg caatggggcc tttttatcag gtgcgtgata tttgccagga aaccatgctg 1176121 caggaagtta ttcccgagca gaaacgaatc ggaatcatgg ctgcaaaaaa tgcgattttg 1176181 actccttggt caggcgtcac ctactccatt atggggctag tggctgatgc tgctggtgcg 1176241 aaaatagctt ttatcgcggc tgctgcatta tatatcatga catttctgat tgcactggcg 1176301 cagccccgtc tggttcatta caggcgagaa aatcgagttc aatgagaaac acttcaaaat 1176361 gaacggagca gctggctccg ttttgctgaa aaaaaaatga aaccatggcg gaagttcgca 1176421 cgtctttata gatgtaaggc tgtttaaaca agaagaaatg gggtatatct aaaagtatga 1176481 agacaacgaa ctcataagga gcaaatcaat gaactggtat gaaaagctta gcgagtactt 1176541 tccaattgaa gaaatgaaat caaaagcgca tatggaagct cttctgaaag agcgaagcga 1176601 tatttatcat aaagatgaag gcaaacatca tattttaatg tttgcggaat tcgattcttt 1176661 tatcttcgtt gattatctgt atgtgtctaa ggatgcaaga gggcaggggc ttggcggcaa 1176721 attgatcgcg aagctgaaaa agaaaaataa gcccatattg ctcgaggtgg aacctgtgga 1176781 tgaagatgat actgatacag aaaaacgcct gaggttttat caaagagagc atttcaagca 1176841 tgctcagtca attgggtacc ggcgccggtc attggctacg aatgaagtaa acaagatgga 1176901 gattctgtac tggtcaccaa aaacagaatc agaagaagaa attcttgaag ccatgaaaca 1176961 gacatatgaa aacattcata cttataaaga tgagaaatgg tacggagaat cgtacgaaaa 1177021 aacggatgag gtcttggaaa tcatcgatga agaaaaacaa aaaaatattt tcgatcagtt 1177081 aagctaattg agaataagaa catatcatga acattaaaaa tttgctggat tgacacattt 1177141 ttttcttagg atactgttca cacttacttt tttatagtat aatacctgta aagattcctt 1177201 ttttagagta atttcaattt aagaataaaa tagatgttca tcctactaat tagaggagtg 1177261 aagatgaatg gttacactat acacatcacc aagctgtact tcatgcagaa aggcgagagc 1177321 gtggctcgag gagcacgaga ttccatttgt agaaagaaac attttctctg aacctttatc 1177381 aattgatgaa ataaaacaaa ttcttcgaat gactgaggac ggaacagatg aaatcatctc 1177441 aacccgttca aaagtattcc aaaaactgaa tgtgaacgtt gaatctatgc cgctgcaaga 1177501 tttgtaccgc ttgatcaacg agcatccagg tttgcttcgc cgtccgatca tcattgacga 1177561 aaaacgtttg caggtcggat ataacgaaga cgaaatcaga cgtttcctgc caagaaaagt 1177621 tcgctctttc caattaagag aagcacagcg tttggcaaac taatagatcg tatcatcaaa 1177681 agaaggctga gtcatcagcc ttcttttatt tttcaacctg ctggtaataa atgctcgcaa 1177741 ggatgacaaa cgcaaccgtc aaaatgggga ggagcgtttc gactgtgccg tgctgcgcca 1177801 taaaaagcga cagctttttg tctctgacaa tcatttctcc gccagtataa gcaagcagcc 1177861 cgcttcccgc gtaaatcaga agcggtattt tctctagtgc aatatggatg agtttgctgc 1177921 cccaaataat aaccggaacc gatacacaca atcctataac aacgagagaa aactcaccgt 1177981 gtgaagctcc cgcaactgcg atgacgttgt ccagcgacat aaagagatct gcaagcacaa 1178041 tcgttcgtat cgctctccac agggaggtgc tgcttttaat gtgtttcgtg tctttttttt 1178101 caatcagcag ctgatatcct aaatacagca ggaaaattcc gccggcgcac tgcaagaacg 1178161 gaatgttcaa aagatatact gctgcacttg ttaatccgat tctcatggca acggcaataa 1178221 atgttccgag aataatggct tgctgtcttt gcttgtccgg caaatgtctg ctggccatgg 1178281 caataacaac cgcgttatct ccgccgagga tcaggtcaat cccaacaatg acgagcagag 1178341 aaatcagata gtcatgctcc atgaagcggc acctcgcttt cagtccttcg cttgtactac 1178401 tactatatga gacaggtcat attttatgat atcagccgcc tgatctgccg ttttttaggc 1178461 aaaggtgcat ttttatttct tttgtgactg ttttatcata aaatagaaat acaaaggaat 1178521 tcacactggc cttggttaag gttaagatgt ggacggaatg ggtaaagtgt agtaaagtac 1178581 aattaatcgg gagcttagat gtcccttcaa catcttatat agaagggaag gttggcaaat 1178641 ggaaattgaa agaattaacg agcatacagt aaaattttat atgtcttacg gagatattga 1178701 agatcgcggt tttgacagag aagaaatttg gtataaccgt gagcgcagtg aagaactttt 1178761 ctgggaagtc atggatgaag ttcatgaaga agaggaattc gctgtggaag gcccactttg 1178821 gattcaagtt caggcactgg acaaaggatt agaaatcatc gtcacaaaag cccagctttc 1178881 caaagacgga caaaagctcg aactgccgat tcctgaggat aaaaagcaag aaccagcatc 1178941 tgaggatctt gacgccttgc tggatgattt ccagaaagaa gagcaagccg tcaatcagga 1179001 agagaaggag caaaagcttc aatttgtctt gcgatttggc gattttgagg atgttatttc 1179061 tctatctaaa ttgaacgtta acggaagcaa aacgacttta tattcgtttg agaaccgata 1179121 ttatttatat gtagattttt gcaatatgac tgatgaagag gttgaaaatc agctaagcat 1179181 cctgctggag tacgcaactg aatcctcaat cagcatacac cgtcttgaag agtacggcaa 1179241 gctgattatt tcagagcatg ctctagaaac gataaaaaaa cactttgcat catagcaaac 1179301 cgatttcctt ccggaaatcg gtttttttta tgcacgaaaa tgccatttta gagatgtgaa 1179361 aaatcaaaaa catatagaca agcagaaaat acagcgaaca ggagttgatc atcttttcca 1179421 gaaagtatac ttcatctgga aaggagagat gacaattgtt tagtgctgtg actgaagacg 1179481 gccaaatgtt tcaccttcta ggcgctcagc aaaaccagaa attaaagcgg agacggttct 1179541 tctgtccggt atgcggggga gagctagctg tgaagctcgg acttcaaaaa gcgccgcatt 1179601 ttgcccataa acagaacaag tcctgcgcca tagacatcga gccggaaagc gcctaccact 1179661 tagaaggaaa aagacagctg tatgtatggc tgaaaacgca acgggcttca ccaatattgg 1179721 agccgtatat aaggacaatc aaccaaagac cggacgtcat ggcaagaatc aaggagcata 1179781 tgcttgctgt tgaatatcaa tgcgccacta tcgctccaga tgtctttcaa aagcggacag 1179841 agggcttcaa acaagaagga atcatcccgc agtggattat gggatacagc cgcttaaaac 1179901 ggactgcttc gtccttttat cagctttcaa cttttcattg gcagtttatc aatgcaagtc 1179961 catacagaga actgatatgt tattgtcctg aaaggcgttc ttttctccgg ctcagccaca 1180021 tcattccatt ctacacaaac cattcttatt cctcagtcca aacgatccct atccatcggg 1180081 caggtgcagg cgatcttttt ttcactgaac cgaaaccctc aattcaatat tcaggctgga 1180141 cgaaagcgat tcaccgtttt cgccataaac cccatcggtt taactcaaag gaaacaaatc 1180201 gccttaggct gctgttttat gagaaacgac agacgccttt ttcttttctg ccgactgaag 1180261 tgtttgttcc tgttagaaaa ggggcagttt ttaagagtcc ggtttttgtg tggcaggggt 1180321 ttctttattt gtttatgacg gatcttggag gtaaacgtgc gccaattcgt ttttcagccg 1180381 ttttgcagca gtgcaaactg cacattcata ataagaacat tgcactcagg tccgaatgca 1180441 gcgaagagtg tctttcagaa gcggttaaac agtatattga ttttttgtgc aagaagggat 1180501 ttttaaggga gactcagaaa gaagtatatg tgctgaatca gcctgcagga ggcatacact 1180561 ccatgcagga tctcatagaa agagaccgca gctgttttat agaatgagtt tgtcttattt 1180621 ggctcaccct aagacaaagg tggtgggcag gctgtgaaag gcacaaaagg aaaggttttt 1180681 cgtgttttta ctgctttttt ggcattcgtt ctcttcatta ctgcatatga tttgacaaaa 1180741 ggcagtgaaa aaccggaaga tattcacaac acaagtttat tgagaaacag ctgttttttc 1180801 aattggcttg aatcaaagaa gacgaggggg atcaccatgg ctgaggaaaa aaaagcaaac 1180861 caactgcctg acagaagtga ggtaaaggca gaagacacat ggagacttga ggatattttt 1180921 cctagtgatg aggcctggaa taaagaattt caagctgtaa aagaattaat tccgaattta 1180981 tctaagtata aaggaaagct ggcagattca gctgatcatt tatacgaggc tcttacgtat 1181041 caagataaag tgatggagcg gctaggtagg ctgtacacat atgcgcatat gcgctctgac 1181101 caggatactg ggaactcctt ttaccagggg ctgaatgaca aggcgggaaa cctgtataca 1181161 caggccgcaa gcgcgacagc ttatttggtt ccggagattt tatccataga agaagacaaa 1181221 ctgcagcagt tcattcttga aaaagaagaa ttgaagctgt actctcatgc gattgaggag 1181281 attacaaagg aacgtccgca tgtgctgagc gagaaggaag aggcgctgct tgctgaagcc 1181341 tccgaggtac tggggtcatc ttcaaataca ttcagcgtgt taaataacgc agatataacg 1181401 tttccatcca ttaaagacga agatgggaat gaaaaacaga tcactcacgg caactttatt 1181461 aatttcttgg aaagtgaaaa ccgtgaagtc cgcaaaaatg cgtttgacgc agtgtataaa 1181521 acgtacggac aatataaaaa cacaatggcc acgacgctaa gcggcactgt gaaaaaggac 1181581 aacttctacg cgagagtgaa aaagtacaag tccgcgcgtg aggctgcgct ttctaacaac 1181641 agtattcctg aggaagtata cgataacctt gttaagacga ttaataagca tttgccgctc 1181701 ctgcaccgct atattgcgct aagaaagaaa gtgcttgagc ttgatgaagt gcatatctat 1181761 gacctgtata caccgcttgt gaaagatgct gggatgaagg tgacatacga ggaagccaaa 1181821 gattacatgc tgaaaggcct cgcaccttta ggggaagaat atgcctctat cctaaaagaa 1181881 ggactggaaa accgctgggt ggacgtttac gaaaataaag gcaaacgcaa tggggcttat 1181941 tcatcaggag cttacggcac gaatccgtat attttgatga actggcataa taacgtcaat 1182001 aatctcttta cgctcgtgca cgagtttgga cattccgtac acagctacta tacgagaaag 1182061 caccagcctt atccatacgg caattacagc atctttgtcg cggaagttgc ctctacgaca 1182121 aatgaagcgc tccttggcga atatttgctg aacaatttag aggatgaaaa acagcgctta 1182181 tatattctca accatatgct tgagggcttc aggggaacgg tcttcagaca aacgatgttc 1182241 gctgaatttg aacatctgat tcatacaaag gcgcaagaag gcgagccgct tacacctgag 1182301 cttctgacaa atgtctatta cgacctgaat aaaaagtatt ttggagacgg catggtgatt 1182361 gataaggaaa tcggccttga atggtcgcgt attccgcact tctattacaa ttactatgtg 1182421 tatcagtatg cgacaggtta cagcgctgcc caagcattaa gcagccagat tttgaaggaa 1182481 ggaaagccgg cggttgaccg ttatattgac ttcctgaaag cgggaagctc acaatacccg 1182541 attgatgtcc tgaaaaaagc gggtgttgat atgacgtctc cagagccaat cgaagccgcg 1182601 tgcaaaatgt ttgaagaaaa acttgatgaa atggaagagc tgctgatgaa agtcaagcag 1182661 tcttaaaaaa gtaagcctgt gcggaaatga cgcacaggct tttttaaaac cctttaaagg 1182721 ttttccggtg attcaagcgg tagagggtaa acaaaataga cagaaacagc agaggagagg 1182781 taatataaag cggcagcata tgcatcatgc ctaagatatt caagcagaaa aaaacagcaa 1182841 tgcacacaat tgagatcaaa gtagacatca tggcggtcct cctcgtcctt tttccttata 1182901 aggatatgag tgaatgcact tcgttatgtt ttgtgacaaa aatatgaaca ttaagcatag 1182961 aggttgtcaa aagtcgacat cttttgttat cataaggatg tgaaattgat cacaaacaaa 1183021 cattacccct ttgtttgacc gtgaaaaatt tctcccatcc cctttgttgt cgttaagaca 1183081 tatgaaaccg cgcttatccc ggcgcggttt ctttagtgct aaaaatggaa cgtacgtttg 1183141 gttatggcat aaaaaaacag cctcaagcat atgcacgcct gcggctattt ttcacatgat 1183201 tgatattcat cagaataagt gctgagagac ttccaaaaca ttccgtgttt ggcttccact 1183261 ttggcaacct ttttagcaaa cgccagtttt ttcatttctt tttctacctc ttcaaggctc 1183321 aggtcatata caagagcaat ttccttcgag gcaacgaagc ggaaatattc aataaaacat 1183381 tctaaaggcg gtgtttccga cggcttcggc tcgtcgccaa gcatctcaaa taaaatttct 1183441 tcatatacat catatgagta gctgccagga actttaagcc cttcatcctc atgctgcgta 1183501 ttaaaaaacg tcagtgtcgg attaacagaa acatccatct cggcagcaat tttcatgtca 1183561 cattgaagcg ccttgaccgc gctttgagaa tgcagatctt ttttgaattc ttcaagatcg 1183621 agacttgtat tttcagcaat ctccaaaagc acgttttcat ccgtaatatt tttctttgaa 1183681 acaaataggc tctcctgcat atttctgaga aattgcatgc cggcttttcg tccttgcagt 1183741 tcggctgctt taaaagcgag agcagccata taaggcgatg aaagcggctg atcctgttcg 1183801 aaccagacat tgccgtcaca tgacatgcca gagcggctcg cgatcttttc ccatgcttct 1183861 gcgagaagat gcttttttcg ctttttattt aaagcggtaa ggcttgcgga agcgataatg 1183921 cgtaaggtga aaaaacgtcc gtatctgatt ttcagctttt tgatgacggg ctctaaggac 1183981 cagcattcag gacataaagg gtctacaaac atataaattt caagcggttt ttttggatga 1184041 ccgtggcaat gggcgaagta tagctcatgc tgatagtttg tcaagatgat cgatcctccg 1184101 cttccgtttg attcaccata tgccttgctg tcaactccag ccggccaaac aaaaactcac 1184161 gaatttcgcc ctccagccct acatggtcca ttgcgtcctt catacagctg agccacgcat 1184221 cagctctctc gtttgtaatt ggaaagggaa gatgccttgc tctgagcata ggatggccgt 1184281 gttcctcagt ataaagagga ggcccgccta aatactgagt taagaattgc ttctgtttcc 1184341 tggcggtttc tgtcaaatcg cttggaaaaa tcggcttcag caaaggatga gacgcgacac 1184401 gctcataaaa agtatcaaca agttgcgata gaagttcctc tccaatcgct tcataaggtg 1184461 cgttaaacga ttgtcccatg ttgactactc ctttaaatat ggctaatagg aatcataaat 1184521 cctattgcaa aaagtaattt tctgtatttc attgtttcat ctagatttat tttagcaaca 1184581 aggcatcatt tctacaaaca aactgccttt tatgcgtttg atgactcatt tcggctgaca 1184641 gccggggttt gtatttcata tcatatcaca taaaaatcag gaatgcgtaa gatttcactt 1184701 cgcaaaaaaa ccagagggaa agagcacctc tggttacgcg taataaactg aagttatttt 1184761 ttttacatag ttttgcgttt cttggaaagg aggaatgcct ccgtatcggt caacattccc 1184821 cggtccggcg ttgtaagccg ctaatgccat agacacattg ccgtcgtatt tatccagcat 1184881 ttgttttaaa tatttcgttc cgccctccac attttgctgc ggatcaagcg gattggaaac 1184941 gccaagtgag cttgctgttg acggcatcag ctgcatgagg cccatcgcac ctgctccgct 1185001 gaccgctttt gcattaaagc ctgattcctg tttgatgacg gcgcggatca gtttttcatc 1185061 aacgccatat ttatcagcgg cttttttaat cgcactgtca atagagaagt ctcccgaacg 1185121 gatctgattt gcttcatgtt tgtttgaagc tgaatctgca acagctgttt cagtgctttc 1185181 tgccgctttt gtgactgaac ctgaattgct gctcgtatat gagttaagcc catacgctga 1185241 aagcagtgac ggcgctgttg tattcgcgct gttcagcatg ctgagcgggc ttggcgatga 1185301 agaaggtgct gattgctgag atgtcagacc gtttgtatat tggctgagca aagaactgaa 1185361 acttgaaagc gggctttccg tattctgagt gtccgagctg ctgcgtgcat tagatatgga 1185421 ctgtaatgcc tgaagctgaa gtaatgctgc ccaattcgtt acattcacga tgtcattcca 1185481 ccttatatag actttcgttt ttcttcataa aaacgcagaa ttttattttt ggtttcgcgc 1185541 tgaggaatgc tgaattgctg aagcagcttt tcgaaggctt gtctgccctc atgccaatcc 1185601 gccgcctcaa attcaatttc atagtcctct ttatttaaat atcggctgtg gtctaaaact 1185661 attaagcctt tttctgtttc tttttccgca cggtttgttg ctaaagatcc aaagtattgt 1185721 atggcatccg tatcgatctg aagcttgtgc agctggtcct tcacagggcc ctcgggaact 1185781 gaaaatccag cgagatctga tacctctgaa agctgctggt gcgtttccag aagccccaca 1185841 tcagccggct cctttaatgt aaggacatac tttccgtttt ttctgcggat acgaagcgca 1185901 gcatgttttt gtttcagcgc gaagctgtct gtatcaaaat aatgattctt ttgatctgta 1185961 aaatcttttt ctgtcagctg gagtgccgat gctatgtttt tgaattcttg tttggtcagc 1186021 atgtttttaa attcgatttc aatctcttgg ctcatgatgc tcttcctttc cgccctgtaa 1186081 atcttatttt tactattatc tctttagatg ttaggtttat caatatcgag ctcgatatga 1186141 taaaatgaat ctgtactttg tttaaaaaag gagagcatta tgcaaaacag aatcgaaatt 1186201 ttgaatgcaa cattatcgga tgatcagctt cgccttgcct gtcagacaga aggaaacgaa 1186261 gcggaacgca agccgtcagg tcaaatgctt gttgattctg accactttgc ttttgtatac 1186321 atacttgaat tagctgattc ttttgaatat gtcattataa aggaacatgt atggccggaa 1186381 ctgaagcagg cccatgcaca aaaaataccg gttgttttag aggcaggaga ccaaacaatt 1186441 gaactggcag gcctgcatga ggagctggaa tatcttttag aaaatataaa agataatgca 1186501 aactatggag aagaaatgga agaaaaagtg aaacgcgtgt ttttatagaa actggttcgg 1186561 aattggggga tgtatgatgg atgacaaaca atgggagcgt tttttagtgc cgtaccgcca 1186621 ggctgtcgaa gagttgaaag tgaagctcaa ggggatccgc acactatatg aatacgagga 1186681 cgaccattca ccgatcgaat ttgtgaccgg acgcgtcaag cctgtggcga gcatacttga 1186741 aaaagcgaga cggaaaagca taccgctgca tgaaattgaa accatgcagg acattgctgg 1186801 ccttagaatc atgtgccaat ttgtcgatga catccaaatc gtaaaagaga tgctttttgc 1186861 cagaaaagat ttcaccgttg tggatcagag ggattatatt gcggaacata aagagagcgg 1186921 ataccgatca taccatcttg ttgtgctgta ccctttgcag acggtatccg gagaaaagca 1186981 tgttctcgta gaaatacaga tccgtacact ggcgatgaat ttttgggcga ccattgaaca 1187041 ttcattgaat tataaataca gcggaaacat tcctgaaaaa gtaaaactaa ggcttcagcg 1187101 cgcttctgaa gcggcttccc ggcttgatga agagatgtcg gagatcaggg gtgaagtaca 1187161 ggaagctcaa gctgcctttt caagaaagaa aaaaggaagc gagcaacaat aggtaaaggg 1187221 gaagaagagc atgaaatttg ccgtatcatc aaaaggagat caagtttctg atacgctgaa 1187281 aagcaaaata caggcgtatt tattggattt tgatatggaa ctggatgaaa atgaaccgga 1187341 aatcgttatt tcagtcggag gcgacggaac gcttttgtat gcttttcaca gatacagcga 1187401 ccgtttggac aaaacagcat ttgtcggcgt tcacacaggt catctgggtt tttatgccga 1187461 ctgggttcct catgaaattg aaaaacttgt tcttgccatc gcgaaaacgc cgtatcatac 1187521 agtcgaatat ccgcttctcg aagtcattgt gacctatcac gaaaacgagc gggaagaaag 1187581 atacttagct ttgaatgaat gtacgattaa aagcatcgaa ggaagccttg ttgctgatgt 1187641 ggaaatcaaa gggcagctct ttgaaacctt ccggggcgac ggcctctgcc tgtcaactcc 1187701 atcaggcagc acagcctaca ataaggcgct gggcggagcg attatccatc cgtctatcag 1187761 ggcgatccag cttgcggaaa tggcttcaat taataaccgc gtgttccgta cggtcgggtc 1187821 acctctgctt ctcccatccc atcatgattg catgattaag ccgagaaacg aagttgactt 1187881 tcaagtgacg attgaccatt taacccttct ccataaggat gtaaagtcga tccgctgcca 1187941 agttgcatcc gaaaaagtgc ggtttgcgag attccgtccg tttccatttt ggaaaagagt 1188001 ccaggattcg tttattggaa aaggtgaata gaaagaggac atatcgtgga gcattttttt 1188061 atcagaaaga acattacttc cgctgaggac gggatgactg taaaagaata tgccggtgaa 1188121 ctgggaattt cgaaacgtct gctgaccgat attaagtttg gcgggggaga cctgcagatt 1188181 aacggtgagc atgtgacggt caaatacgtt ttgaaagagg gagatcttct tatcgtgaag 1188241 tttcctgagg agcaggtgag cgagacgctg ttggcagagc ctgttccgct cgatatcctt 1188301 tatgaggatg aacatgtgct tgtgataaac aagcagccgt atgtgtcatc aatcccttcg 1188361 agagagcacc cctccggcag cattgccaat ggaattattg atcattatca aacaaccgga 1188421 gtgagggcga cagttcatct tgtcacccgg ttagaccggg atacatcagg tatcatgctt 1188481 gttgccaagc atcgatttgc ccactccatt ttatcgtctg cgcaaaaaaa cggccttgtg 1188541 aaacgccggt atgcggcagt ggttcacggg cggatggcac agatggaggg aacagtcgat 1188601 gctccgattg gcagacatcc tgacagtatt attgaacgga cggtaacgcc agacggccag 1188661 aaggctgtta ctcattttta cgtcacatgt gcaaatgatg acatgacctc ggtggcattg 1188721 cagcttgaga ctggacgaac ccatcaaatt cgtgttcata tgagctatct cgggcacccg 1188781 ttgtgcggcg atacactgta cggcggaacg agacaggaaa ttggccggca ggctctgcac 1188841 agcgagcatc tttcgtttat ccatccgctg acacaggaga acatgaggtt tcatgctcca 1188901 ctgcctcagg acatgagcaa actgataaaa ggagagaatc attgattctc tcctttttta 1188961 tatggggcga aatcttgatt cgtcgtaagg cagggagctt ggaacagaga cggtttctat 1189021 ttctggaaag cgaaagcctg tcagttgatt tccgaacacg cagcctgtat caatgttgat 1189081 ggtgcgattg accttccgag gctctttcac aggtgtatga ccgtatacca cccaagcctt 1189141 tccgttatag gctgccgccc aatcacgcct gatgggtctg ccgtccggat atgtttcacc 1189201 cgtcacgtca ccgtaaagca caaagtcctt cactctgcgg gtatatttgc cgatatcgtc 1189261 agctcttatg ccagcatggg cgacaactaa ttctccatta tgtaagatgt cgtaaagcgg 1189321 cgctgtttcg tacagcttca taaactgttc gctgactgat tttttctcat ctttggaaag 1189381 ttcctcaagc tctgccgctg ttgtttcgag accatgcatc acttttaccg gatttccttt 1189441 taagtaacga tataatttat tgcaatggtt tcccgggaca taacgcacag cgcctttttc 1189501 gtaagcgccg gctacaaatc ggatgacctc tatcgatttg ggccctctgt cagttaaatc 1189561 tccggcaaaa acaagcaccc tgccttcttc atggacaggt actccatttt tgattgtata 1189621 gccaagcttt tggattaatg cagtcatttc gtcatagcag ccatgaatat cgctgatgat 1189681 atcgtaagcc atgcggtctc ctccttaccg attgttttat ttattatgaa gcaaagtgtt 1189741 gtgagtcatc acaagctttt atgtgcaaat tatagaagaa gaatcatttt ctaaacagga 1189801 ttaagacctt atcactttat ttttcatcat cacccttgtt aaaatcgcgt tatgtttttt 1189861 aaaaatgagg ttttgttctc tgagtgagaa ctagcataac cctgacttaa aaaggaggtt 1189921 ctgattatgg cgcatacatc tgtcgcatct ttagttgttg tacttatcgt tgcatttttg 1189981 acacccatcc ttttgcatcg gtttaaactc agcatcccgg ttgttgttgc tgaaatcatt 1190041 atggggctga taattgggaa aagcggcctt aatttagttg tggagggtga cacctggctc 1190101 cagacactct ctatgctcgg atttatcttt ttaatgtttt taagcgggct tgaaattgat 1190161 ttttcgtcgt ttgagaaagg aaagaaaaag cagttcctgc cgaatggcaa ggaagcgccg 1190221 aatacgtttg ctgcggcatc tgttattttc gtcggtattt ttattttatc attgctcttg 1190281 tcctatgggt tcgtcttggc cggatttatc caaaatgcat ttttgatgac cctgattatt 1190341 tcaacgattt cattaggcgt tgtcgttcca acattaaaag aagaacggat catgaattcg 1190401 aatatcgggc agattatttt gcttgttgct gttattgctg atttggccac gatgattctt 1190461 cttgctgttt tttcttcttt atacggagag gacagcggaa acatgtggct cctgatgatt 1190521 ctgtttgcgg ccggagtggt gctttacttt ttcggccggg tcttcaaaca tcgctctttt 1190581 gttcaatcca tgtcaaaagg gacgatccag atcgggacgc gtgccatttt tacgttaatc 1190641 attgtactcg ttgccctgtc tgaatcactt ggggcggaaa atattctcgg cgctttctta 1190701 gcgggggttc ttgtttccct gctttcgcca aacaaagaac ttgttcagca gctggactca 1190761 ttcggttatg ggttcttaat accgattttc ttcgtgatgg tcggtgtgaa gcttgatatt 1190821 tggactcttt tccaggataa aacaatttta atcatgattc cgctcctgct gcttgcgctg 1190881 ttagtcagca aaatcattcc tgtcatgtac ttaaagaagt ggtatgataa ccgaaccatt 1190941 ttcgcgtctg gtttcctgct gacatcaacg ctttcgctcg tgattgctgc tgcaacaatc 1191001 ggccagcagc ttcacgtgat cagtacaaat atgtcaggag cgctaatttt agtagccgtc 1191061 attgcaagta tttttacgcc gatctgtttt aaaaaattat acaaacggga agagcagccg 1191121 gaggagaaaa agacgattac gttcattggc gccaatcaaa tgactttgcc tgtcacactc 1191181 gaattgccag aggaagagta tgacgtgcgt gttgtacacg tctaccaaga gaatgcggag 1191241 gaaaagctgt cagaatcagt gtttgctgtt gaaacaattt ctgactatga acacgagacg 1191301 cttgaatcac tcggcatttt tgaaacggat atcctcgttg tggcgacagg aaatgaagat 1191361 atgaatgcag acattgcatt acttgcaaaa gataaaggca cagaaagagt cattgcaagc 1191421 gtaggatcac cggagcatga agcagctctg aaggagcagg gaatcagcat cttttctatt 1191481 ctgctgtcga caaaaacgct gcttcgcgca ctgattgaag cgcctggcgt catgaagctg 1191541 ctcacgaacc aagagtcttc gctgtatcaa attaatatgg agaacagtaa atatgatggt 1191601 gtcattttac gggaattccc tttaacaggt gacgtcatct ttgtcaggat cttcagaggt 1191661 gtggacagca tcgttcctca tggggatacg aggctgaaac ttggagaccg tttaattgtc 1191721 accggatctc gggggtacgt aacggatctt aagaaaacat tggaaggata aatcttgacc 1191781 aaataaggat tcgtgttaat atagaggtgc agaacaattc aatatgtatt cgtttaacca 1191841 ctaggggtgt ccttcataag ggctgagata aaagtgtgac ttttagaccc tcataacttg 1191901 aacaggttca gacctgcgta gggaagtgga gcggtatttg tgttatttta ctatgccaat 1191961 tccaaaccac ttttccttgc gggaaagtgg tttttttatt ttcagagggg gaatgatttg 1192021 tgaagttttc agaagaatgc cgcagtgcag ccgcagaatg gtgggagggg agctttgtcc 1192081 atccgttcgt tcaaggaatc ggtgacggaa cgcttccgat tgaccgtttt aaatactacg 1192141 tacttcagga ttcctattat ttaacgcatt ttgcaaaggt gcagtcattt ggtgccgctt 1192201 atgcgaagga tctttataca acggggcgga tggcaagcca tgcccaaggt acatatgagg 1192261 cggaaatggc gcttcatcgc gagtttgccg agctgttgga aatcagcgag gaagagcgta 1192321 aggcgtttaa gccgtctcct acggcgtact cttatacatc ccatatgtac cgttcggttt 1192381 tgagcgggaa tttcgcagaa atcttagcgg ccctgctgcc atgctattgg ctctattacg 1192441 aggttggtga gaaattgctg cattgtgatc cggggcatcc aatttatcag aagtggattg 1192501 gcacatatgg cggtgattgg tttagacaac aggtcgagga gcaaatcaac cgctttgatg 1192561 agctggcgga aaacagcacg gaggaagtgc gtgccaagat gaaagagaat tttgtcatct 1192621 ccagctacta tgaatatcaa ttttggggaa tggcctatcg aaaagaaggc tggtctgaca 1192681 gcgccataaa agaggtggag gaatgtggag cttcacgcca taacggatga cagcaagccg 1192741 gtagaagagc tagcgagaat catcattacg attcagaatg aagttgattt tattcacatt 1192801 cgggaacgct caaaatcggc ggcggatatt ttgaaactgc tcgatcttat ttttgaaggc 1192861 ggtatagata aacgaaaatt ggtgatgaac gggcgcgtgg atattgcact tttctctact 1192921 attcaccgcg tgcagctgcc aagcggcagc ttttcaccga agcagatcag agccagattt 1192981 ccacaccttc atatcgggag gtcggtgcat tcactggagg aagcggttca agcagaaaag 1193041 gaagacgcgg actacgtgct gttcggccat gtgtttgaaa cggattgcaa aaagggtctt 1193101 gaaggcagag gagtatcttt gctgtcagat atcaaacagc ggatttccat cccggttata 1193161 gccatcgggg ggatgacgcc ggacaggtta agagacgtaa aacaagcagg ggcagacggc 1193221 attgctgtta tgtcaggaat tttctcttcc gctgaacctt tggaagcagc cagacgatat 1193281 tcccgcaagc taaaggagat gcgctatgaa aaggcattat gaagcagtgg tgattggagg 1193341 cggaattatc ggttccgcaa ttgcttatta tttggcaaag gaaaacaaaa acaccgcatt 1193401 gtttgaaagc ggaacaatgg gcggcagaac gacaagtgcc gctgccggaa tgctgggcgc 1193461 ccatgccgaa tgcgaggaac gtgacgcgtt ttttgatttc gctatgcaca gtcagcgtct 1193521 gtacaaaggt cttggagaag agctttatgc attatccggt gtggatatca ggcagcataa 1193581 cggcggtatg tttaagcttg cattttctga agaagatgtg ctgcagctga gacagatgga 1193641 cgatttggac tctgtcagct ggtattcaaa agaagaggtg ttagaaaaag agccgtatgc 1193701 gtctggtgac atctttggtg catcttttat tcaggatgat gtgcatgtgg agccttattt 1193761 tgtttgcaag gcatatgtga aagcagcaaa aatgcttggg gcggagattt ttgagcatac 1193821 gcccgtcctg catgtcgaac gtgacggtga agccctgttc atcaagaccc ctagcggaga 1193881 cgtatgggct aatcatgttg tcgttgccag cggggtgtgg agcggaatgt tttttaaaca 1193941 gcttggactg aacaatgctt ttctccctgt aaaaggggag tgcctgtccg tttggaatga 1194001 tgatatcccg ctgacaaaaa cgctttacca tgatcactgc tatatcgtac cgagaaaaag 1194061 cggaagactg gttgtcggcg cgacaatgaa gccgggggac tggagtgaaa caccggatct 1194121 tggcggattg gaatctgtta tgaaaaaagc aaaaacgatg ctgccggcta tacagaatat 1194181 gaaggtggat cgtttttggg cgggactccg tccgggaaca aaggatggaa aaccgtacat 1194241 cggcagacat cctgaggaca gccgtatttt atttgcggct ggccatttca gaaacgggat 1194301 cctgcttgct cccgcaacgg gcgctttgat cagtgatctc atcatgaata aagaggtcaa 1194361 ccaagactgg ctgcacgcat tccgaattga tcgcaaggag gcggttcaga tatgatgcta 1194421 cagctgaacg gtaaagacgt gaagtggaaa aaagacacag gtacaattca agacctgctg 1194481 gcgtcgtatc agcttgaaaa taaaatcgtt atcgtggaaa gaaataaaga aataatcggg 1194541 aaagaacgct atcacgaggt tgagctttgt gatcgtgatg tcattgaaat tgtccatttt 1194601 gtaggaggcg gatgagcatg ttaacaattg gcggaaaatc atttcaatca agattgctgc 1194661 tgggcacggg gaaataccca tcgtttgaca ttcaaaagga agcagtagct gtttctgagt 1194721 ctgatatttt aacatttgct gtaaggagaa tgaacatttt tgaagcatct cagccgaatt 1194781 ttctggaaca gcttgattta tccaaatata cgcttttgcc gaatacagcg ggcgccagta 1194841 ctgctgaaga agcggttcgg attgcaaggc tggcgaaagc ttcaggcctt tgtgacatga 1194901 ttaaagttga agtcatcgga tgcagccgtt ccttgctgcc tgaccctgtt gagacattaa 1194961 aagcgtctga acagcttctt gaagaaggct ttattgtgct cccgtacacg tcggatgacg 1195021 ttgtgctggc gagaaagctg gaagagctcg gcgttcatgc catcatgccg ggtgcatctc 1195081 cgattggatc aggacaagga atcttaaatc ctttgaatct gtcgtttatt attgaacagg 1195141 cgaaagtacc ggtcatcgtg gatgcgggaa tcggctcgcc taaagatgcg gcatacgcaa 1195201 tggagcttgg agcggatggc gtactgctca atacggctgt atctggcgct gacgatcccg 1195261 tgaaaatggc tcgtgccatg aagctcgcag tggaagcagg gcgcctttct tatgaggcgg 1195321 gccgaatccc gcttaagcaa tacggaacgg caagcagtcc gggagaaggt cttcctgtat 1195381 gacaggcagg tattcaaggc aggagctgtt tgctccgatc ggcccatccg gccagaaaaa 1195441 attgaaagaa gcgcgcgccg tgattatcgg cgccggcgcg ctcggaacag ccagtgcaga 1195501 aatgctggtg agagcgggag tcggctctgt gaaaattgcc gacagagatt atgttgaatg 1195561 gagcaacctc cagcgccagc agctttatac agaagatgat gtcaaaaaag aaatgccgaa 1195621 agcagccgct gcggagcgcc gtctccgttc gattaacagc gatgttgatg tgaccggcct 1195681 tgtcatggat gtgacagcag aaaatatctt cgagctgatt agggatgcat cgattattgt 1195741 ggatgcggct gataattttg aaacccgcct gatcgtaaat gatgctgcgg taaaggaagg 1195801 gattcctttt ctttacggtg cctgtgtagg gagctacggt cttaccttta ccgtggtgcc 1195861 gggttctact ccttgcctgc attgcttgct cgatgcactt ccgattggcg gagcaacatg 1195921 tgacacagct ggcatcatca gtccggctgt tttgcaggta gcagtctttc aggtaacaga 1195981 tgcactgaaa ctgctgacgg gagaggagtg cgagccggtg ctgcgctcct ttgatttgtg 1196041 gaaaaacgag cggtcagaag tgagagcggc cagtctcaaa catgacgcat gcccaagctg 1196101 cggcacaaag gattttccgt ttttgtctta tgaaaatcaa acaaaagcgg ctgtattgtg 1196161 cggcaggaac acggtgcaga tcagatcatc tattacgaaa gaagcggatc ttgaagcgct 1196221 tgccggtcag ctgaggcagg ccgggcttga agtagctgcg aacccgtatt taatttcctg 1196281 ccgctcggat gatatgaaaa tggtgctgtt ccgggacggc agagctttga tccatggaac 1196341 aaatgatatt gcccgggcaa aatccattta tcataaatgg attgggtaat aaaaggagtg 1196401 tagtgtaatg agtatatata aagcattgac aatcgccgga tcagattcag gcggcggcgc 1196461 agggatacag gctgatatta aaacctttca agagcttgat gtattcggaa tgtctgcgat 1196521 tacggcggta accgctcaaa atacgcttgg cgttcacggg gtgcatccgc tgactgtaga 1196581 gacgttgaga cagcaaattg acgctgttgc tgaggatttg agaccggatg cagttaagac 1196641 gggaatgctc tggaatgccg acatgattga agaagtggca agaaaaattg acgagtacgg 1196701 attcaatcgt gtaattgttg atccggttat gatcgcaaag ggcggggcat ccttgctgcg 1196761 tgatgagtca gttgccacct taaaggagtt gctcattcca agaagctacg cgattacgcc 1196821 gaatgtcccg gaagcagaaa cgctgacagg aatgacaatc agctcgctgg atgaccggaa 1196881 aaaagcagcg gagcagctcg tcaagatggg tgcgcagcat gtcattatca aaggcgggca 1196941 ccagcctgag gacaatcaca ttactgacct tctttttgat ggcagcatgt ttatgcaaat 1197001 cacccatcct tatatcaata cgaagcatac gcatggcaca ggctgcacct ttgctgcggc 1197061 tttaacggcc caaacggcta aaggagacag catccatcag gcatttgagg ttgcggccaa 1197121 ctttgtccgt gaagcggtgg aaaatacgct cggcatcgga tcgggacacg ggccgacaaa 1197181 ccatttcgct tttaaacgaa acagcttaaa tacaagccga tgagatcacc agctgatggt 1197241 gatctctttt gcgtttgcta cggtatgcgc ttttcatctg gacaaggtta tgatatgata 1197301 ggaattaaga tcaggtacta atactatgtc tttattaaat ataggaggct ttatacatat 1197361 gaatttttca cttgaaggcc gtaacattgt tgtgatgggg gtagccaaca aacgcagcat 1197421 cgcctggggc attgcgcgtt ctttacatga agcgggtgca cgtttgattt tcacatacgc 1197481 tggtgaacgc ctggagaaat ccgttcacga gcttgccgga acattagacc gcaacgattc 1197541 catcatcctc ccttgcgatg ttacaaacga cgcagaaatc gaaacttgct tcgcaagcat 1197601 taaggagcag gtcggtgtaa tccacggtat cgcgcattgt atcgcgtttg ccaacaaaga 1197661 agagcttgtc ggcgagtact taaacacaaa tcgtgacggc ttccttttgg ctcataacat 1197721 cagctcatat tctctgactg ctgttgtcaa agcggcacgt ccgatgatga ctgaaggcgg 1197781 aagcattgtc actttgacgt accttggcgg agagcttgtg atgccaaact acaacgtcat 1197841 gggtgtagca aaagcttctc ttgatgcaag tgtgaaatat ttagctgctg acttaggaaa 1197901 agaaaatatc cgcgtcaaca gcatttctgc cggcccgatc agaacattat ctgctaaagg 1197961 catcagcgat ttcaactcta tcttaaaaga catcgaagag cgtgcaccgc ttcgccgcac 1198021 gacaacacct gaagaagtgg gcgatacagc tgcgttcttg ttcagcgata tgtcccgcgg 1198081 gattacaggt gaaaatcttc acgttgattc tggtttccat atcactgccc gctaagcagg 1198141 atctatatca agcaatcccg aatagggatt gcttttttat ttcttctgat tttcagcttt 1198201 ctgtcatata gatagaatat gacacaatcg gagggatgaa gatgtctaat aagaaaagaa 1198261 acgcggataa aaaaccgctc atgtatattg ttcagccgga ttatgcagaa actacaaggt 1198321 catccatgca ggagattgtc atcaaaagaa aggccgacaa acccgctccg ccaaaagctg 1198381 aggaaaagcc ggcttaccat gagaagcagc aggaggaagc cgtggcacag gatgtcctgc 1198441 aagaagacca aaagcctgca gccgaaccag tgagtcagca aacacaagag gcgagagagc 1198501 cagagaacat aaaaagccaa gaggaacaga aggcagagcc gcaggccgta gaagaaaccg 1198561 ttgaacacga gcccccgaaa gcagaaaaaa aggaagagcc tgcacttgag gcccggaagc 1198621 ctgagaaaga accggaagct gtccatagtg ctgataaagc ggaggaaaaa gcaccgccgg 1198681 cacgaaaagt gaaaaaaccg atgagcaaga tgacgatcca cgaaaaaatt gattttttaa 1198741 caaagctgcc tcataacatg ccgagagcgc tttgtttgat tgaagccaat ggaagaacgt 1198801 acaggggcgt gattgtcgga agaagaaatg attccgtcct gcttcgaaca accggaaacg 1198861 gagccccaac cgaactggca atcgatgata ttacctcttt gcacccgctc ggtttttaac 1198921 gaaaaagaaa aaagctgccc ggctgatgtt gccggacagc tttttttaca tagagaaaag 1198981 cctgcaggcc tgcaagcttt tccagcttat gattaatgat gatgtgtacg attgattaat 1199041 cgaggattta agcagttgat tgcgcagaag cagtctaagt caacttcaat acagtagttc 1199101 gttttttcga gtcggaacac ttcacacacc gtatctttat cggtgaagtc caaaatgtgt 1199161 ttgtgttcgt caaatgcgat taataatgac agtgttgcac agcttccatg cactctttcg 1199221 accctgaaaa atactgtatt aaagcaaggg ccgttatcga gttcgccgac atttccgaag 1199281 gcgactaatg gcgttgattt tgatgtaaat attgcaaaag gcactgtgtc gcctaacgaa 1199341 tggcttacag ataaaagctt agagtggcag ccggtcgggc agtcttcttc aacagcgttt 1199401 tgcagatctt caatattttc tacagcttca cgcacgcagc ttgatgtttt ctggctcata 1199461 ttatccctcc tgccttataa atttgagact ggcgaaatga tggagagtca gctgcctcac 1199521 gctggaagca gctgaatgat ttgcacctgt aatagagttt ggaaggggat tcctctttac 1199581 aagtgtttat ccattgtgat gatgcttttt atctttgtga ggcgatgttc tgtcaactag 1199641 ctctggtgac aggcactgaa tcgcgcagaa gcatccgaga tccacttcaa tgcagaaatc 1199701 tgttttttct agcccgaaga aatccgggtc gcaagggtgg caaacactta aggtatcgcc 1199761 tttgacatcg accgggcgta aaatagacag tgttgcacag caatcgcata atttttcgac 1199821 gcggaagaaa atggattcaa agcattgcat atcatccaca aatcccccta cgtttccgaa 1199881 tgtggagaac aatccgcctt ttttatcaaa aacgagaaac ggaattgtgt cttttccagc 1199941 aatcgtaggg tttaaaaggt tggtatagca gccagtcgga cactgttctt caactgcctc 1200001 ctgctctgct aaaatctttt ccactgcatc gcatacacag ttctcatgcc ggccatgggt 1200061 ttttccgcag ctcattgatt tcagctcctt ctttataggg tatttgactt tagtccttaa 1200121 caacatatgt acccgtgccc cacttggtgt gggtgaacgt ctatatattc atcatatgct 1200181 tggaaaataa gaaaaagcag agcgttttta gctctgcttt taggtcctag aggacaagag 1200241 tgataactag gatggctacg agtgtatttg ttgctgtaga aataagggtt gcgatatcgg 1200301 catctactgt tgtgacgttt acgccgcggg aacattcgat gagaagtttt tggcggttta 1200361 cttgtttgtt agctgtaagc tgtaacaaat cttgtgcgac taattcggca attacgccgt 1200421 ctgcaattga tgtcagagtt gccgttacga cagcggcatt aagtgctgtt acaactgatg 1200481 ttacggcttg aacgtctgta gatgtaacat tgatgtcaca agaatctcta ataataatcg 1200541 tttcatctga aacttgtttg ttgagatttg cttgagctag atcttggtcg atgaaggcgt 1200601 tgtcgttgcc aaaaaaacca ttgccattac agcaaacgtc gcaatgacat tttctttcgt 1200661 gtttttcttt atctttctct ttgtcatcta acggatggtc acagtcagga tcaagtgcaa 1200721 cccaagaata tggtctgctt tccatatcta ttcctccttt tcttttactg ttattaaatg 1200781 agcgagcctc ttattttgac tgagtcatat atcctgatga agaaccctat tttttatgat 1200841 tggctaattg ttatcgtttt tccgtctttg tctgatctgt tcaatgagct gctctctgcg 1200901 gcttaacggt tttgtgttct tttgctcttg tgcggctgct tcttcttttt tcttcttttg 1200961 gttttctatt agcgcttgtg atttagcttg taagtctttt acaagattta agagcatttc 1201021 tttttcttcg tctgatactt ttttcatttt gtcttttgtg accccatgtt tagaaaatat 1201081 attttggacc agcattttcg tcattggatc aacttctgga agctttgcaa gctcttcttt 1201141 gaatttatcg ttatctgaca tttgttttca cctcgtcttt taagtttgtg aaaagaaagg 1201201 gttaaaggac gtcaagttca ctaagaatgc tgtttaacac ctgaagcaag atttgtacaa 1201261 aggttattat ctcgtcggca gacaaagtaa ttttgatgtt gcggctgttg ataattttaa 1201321 tgatggttct ttttttgatt tgggagctat cgagaataag aatttcactt gccactgcgt 1201381 cagccaaatc ctcgtcggcg atgacgagct gagtcgccac gataatcatg gttgtcacaa 1201441 aggcttgtat agaaagggca gctgttatat gtgacgtgtc aattgtgata ttttcgcaat 1201501 caatcacttc gatctgctgt tcgaattcgc ttgataattg ctcaaatatt gcagggtgca 1201561 gggattcgac tttttcttca aatgacataa ccttcactcc tttcttatcc atactctata 1201621 taatgcaaat ggggtgcaga gcggaataat aaaaataacc aattttctgc cggacaagat 1201681 acaattcatg aagaataggg ttttggcata tatgtgaagg gatcatgatt ggcaaaggag 1201741 tgaacgagtg gttataaatg ggctgacaat tgttcttcta tcgcttgcgg tctttcggct 1201801 cgcccgcctg ctggtgtttg acacgattat ggcgccgctt cgcagtctgt ttcatgaaga 1201861 gaaggaagaa aaggatgcgg acgggaacat tgaaacctat atcgtgatta agggaaccgg 1201921 tgtcagggcg tttattggtg aattgctgag ctgctattgg tgcacaggcg tgtggtgtgc 1201981 cggctttttg attttatgcc aggcggtgat cccgcaagcg gcgcagtggc tgattttact 1202041 tttggcgatc gccggccttg ccggcattat agaaacgctc gtatcaaaat ggctgcaaga 1202101 ataaggcgtt accaccagca actttctgtc agaatacgca taaagtagca tatatgacat 1202161 aaggaaagga aggggacaaa aatgaatcag catcataaac cttcccaaaa atctccatat 1202221 acagattcat cgtatcaatc aaaaaagata aaaaagaaag gctgcgggtg cggaaataaa 1202281 aagaaaaagc ctcaatagcc tggcaaagaa accggagaac tccggttttt tgttttttta 1202341 acgaggcggt ctcgctcagc atatatcata agcgggggga taaaagtgaa tgagtttgaa 1202401 aaatggatag aaggaagata tgaaccacat gaacaaaagc aaaaagagca tgaagacacg 1202461 atgggcagta tcagaaaaga cttggatgca tttgataaag ccggtctgga atttgaagat 1202521 gagattgaag agctggctga aaaaacggag gccttactta aaaaacatca agctcaatat 1202581 gatcaatcgt aaatccgcaa acgccctatg cgaatatcca agccgatccc agcagctcac 1202641 atagtgtata gagagtaaag gaggtgctta tctatgggct ttggatacgg attcggcggc 1202701 ggctacggcg gcggctgtta tggcggttat gctggcggtt acggcggcgg ctatggttca 1202761 acatttgttt tgttggtcgt attattcatt ctcctcatca tcgtaggtgc atctttcttt 1202821 taagatgtat tgaggaagta cgggttataa cccgtacttc cttgccttgt gtttattttt 1202881 aaaaatgttg gaaaagcaca ttgtattatg tgcattcata caataccgta ttactccgcc 1202941 aaaaggaggc gcattatgga taatcaattt tttaagaaca tcgaaaagaa aacaggtgtg 1203001 aagatgcagg atgtaatgaa tcttgccgga tcactccaaa acgctaattt taaagatgaa 1203061 aatacagtgc gcagtgtgat taaccgcgta gcgcagatgg caaacagacg cgtgccaaaa 1203121 gaattagaag ataaaattgt ggaatctatt acaagcggaa aagaaaagct tgattttggc 1203181 acgatttcta aaatgatgga taataaataa gtggatggcc tggctgactc actgcagcgg 1203241 gccttttttt acagtaaaaa cccggcagta atctgccggg ctgttaatga tgcaagggct 1203301 gtcttgcttt ctgtagcagg ggatacaaaa atcttgagcg gttggctgtt ttgccgcgcc 1203361 tgttagcagg gcaagacaaa tataaatgct gtttcgcccg ggtcatggct acatataaaa 1203421 ggcgtctttc ctcctcaaga gcggcctcgt ctccttttct tgccgtttct aatgagaaat 1203481 cgtgcggaat cgagccatct acagtgccta acacgtagac tgttttgaat tcaaggcctt 1203541 ttgaccggtg aatggtcatc agctgaacgc catgttcatc cgttctgttt ttctcagcgg 1203601 ccctcatatg gtctacgtgg gcaagaaagt caggaatcgt tttgaacttc ttggcgacaa 1203661 ccttgatgtc gcgcaggtca tcagagcctt tttccagctt gttgccctca ttgccccgct 1203721 tttttaaata ctcggagaag cccatttttc cttctgcaaa ggtgatggct tctacgggtt 1203781 tcattgtgcg gaggcttgca aaaaacggta cgattttctt gattttgtcc agctggaatg 1203841 gcttcagatc aggcaatttg gccagcgctt tgatcatggt acagtcctct gtaatcgaga 1203901 gcgccttcag cgtattcaaa gcggactgtt ttaaaaacaa ggcgggaagc aagtgtttaa 1203961 tcgcctcggt gtcatcctca ttttggctgg cgtacaagta ggcgagaatc tggcggacga 1204021 tccgtctgct gtaaaacgat tggacgccgc ggtcagctgt atacggaatt gacgattgat 1204081 gaagcctttc atatatagca cggcctccgc tgtttgtgcg gtaaagaacc gcaaagtctt 1204141 ctggactggc tccattttga attttttctt tgatatcgga aacgaccatt gtggcttctt 1204201 cctcttcatc ataaggataa aacagcacag ggacctgaat gtcatcgcgg gccgcttcaa 1204261 gcgttttggc atatctgttt ttgttctttt tcacaacgat atcagcacta gagacgatcg 1204321 ggtgcgtaga cctgtagttc gcagttaaat agatcgtctt cgctcccgga taatcctttt 1204381 gaaaatcaag aatgaaagac ggattgcttc cgcgaaacgc gtagatggac tggtcatcgt 1204441 ctccgacaca gcacaggttt tgctccgggc tggcgagcat ttgcatgatt ttgtattgaa 1204501 ccggattaat gtcctgaaac tcatcaatta agatatacgt aaaccgagat tgatattgtt 1204561 ccagaaggtc aggccgctcg ataaacaatt catagcaggc tgaagccatg tcatcaaaat 1204621 caaattggct gtgttctttt ttctggcgtt cataatgttc atataaacga taaacttgtt 1204681 tttcccactc atcttttaga gggatgcgtt catttgggac ataagtgttt ttccaaaaac 1204741 cgatctgctg cagggcttgg tcaactgggg attctttctc atcgatgcct tcttcataga 1204801 gtgctttttt gatatattgt tcccgctgcc actccatttt cagcagatgc tcaccgttcc 1204861 atttagcaga attagagtga tacaagatct tataaaacag actgtggaat gttcctgtca 1204921 caattcttct gacttttgcc ggctgtaatc cgtactggtt cgccatacgc tctttcattt 1204981 cagcgacagc ttttgttgta aaggtgacaa gcagcatatt ttcaggcggt atgcctaagt 1205041 gttcgatcat gtgggcggca cgggctgtca gtacccgtgt ttttccgctc cccgcacctg 1205101 caagcacgag gagcgggccc tctgtttccg tgacagcttt cagctgatcc gtgtttaaac 1205161 cgacagacgg aaaaaggctc gtatcgggtt ctattgtttt tggcacaaat ggtgttcctg 1205221 gtttaatgct tctaggacgg tgccattctg taacagctgg ggacgggtca gcggcgatcg 1205281 cttttccctt gggtaaacga atgacaccag attcctgatc atcttctttt ttcccctctt 1205341 tagagggctt cggttcgcac gcctcctcac atgccggaaa atcgcctggc tggcgatgga 1205401 taaactctgg cggatcggcg atgttaagcc gtaacaaaac gggctttccg caatgagaac 1205461 aaaataaatg tccttttatt ccctcttcaa agaggaattg ataatgttct ctcgaatatg 1205521 tatgtaaatg tatgattcta tcattcagtc gggcgcattt caaaaagggg tcctcccaat 1205581 caaaaggtgt tcattacaga caatgactat catatcaaaa gaaatgtgtt tcaaaaagta 1205641 agtttaaggg aaaagagaca gcagaggggt gggtattgta tgatatatgc aggtcaaatt 1205701 cagaaccagc aatacgctca atatgctaat agaacgattg gacataagca ggattatgcc 1205761 ggaaccgaaa aaatcagcta tgtcccgttt cagcgggtat acaaagaact ggaaaagcag 1205821 caggagaatc aaacggcagc tgaaagaaaa gtaaacgaga tgaaacgtaa gcgctctctt 1205881 tataagagat tgcgagaaaa aggaatgggg acatatatta atcgatatgt ataaaaaacc 1205941 gttcatacca gagaacggtt tttttatatg cagtaaaaat ccggatctca aaagatccgg 1206001 atgcgttcag tccttcatca tttgtaagtg cggaatgccg gcatcgagga attctttttc 1206061 agaaagcacg cgatacccgt gtttcttgta aaacggcaca gcctgtgttt gcgcgtttaa 1206121 aatgaaaccg gaagcgcctc cgtctgccgc ggctttttcg agcgctttca taatgatgcc 1206181 gccgacaccg gctgagcggt ggcttttcag tacgcaaatc cgctctaact tgccgtagcc 1206241 gtccttcatg cgccatcttc cggcaccgac aggcttttca ccgtcataca cgacgatatg 1206301 ctctgactca ttttcaagtt cgtcaatttc ttcttcagca ggcacgtttt gttctttgac 1206361 aaagacttct tctcttacat agaatgcatc tttcagttgt tcttcatttt ttgcgataac 1206421 tgctttcaaa cattattctc ctctgcctag caagaaggtt tcatatactg tccacgatcc 1206481 gttttccaac tggtagagca agtggaaacg gtcaacgatt tcttcatgcg acacttcctg 1206541 catttttaat tgtcccagca catctgaatg ctcatcgtcg gaaagatttt ggccgaccgt 1206601 cacatgcgga acgaaattat attcctgttc tcctgccaac acaccggtgt atagcttttc 1206661 attgagtgtt tttaactctt ccgtcggttc tgctttgatg taaatgacat tattgacagg 1206721 cgcaaatgag ctgtattttg tcattttgag aacgagtggg tgggactctt ttgcgatgtt 1206781 tcttaaatgt gatacgagct gatccgcttt ctcctccgcg cattcaaagg atgctctcag 1206841 cgtcaaatga ggcgggatta gagagtagct tgggtcatag cgctttctgt aagagtttgc 1206901 aaggtcttgg agcttttttg atggaaataa aacgattccg tatttcatat tatgtccctc 1206961 ctggaaataa agtatgatag agtgttaaag catttttttc agcgccgggg tgatgagcgg 1207021 ctgccagtat gtccatttgt ggtctccgtc aaatggctcg aaatcataat cggaaagctt 1207081 tttctccagc agctgtttca gctcccggtt cggttctgta aagtccagaa tgttcccgtc 1207141 tgtcgtgtgg acgtcagttt cttttgttcc gatttggtga taaatagaga ggtgtttgat 1207201 atcgtctgac tgttttacgg cttctagtac gtgtttgtca acatagggag actgcatgat 1207261 gatgttgcca aacatattcg gataatcaag cgctgtcata agtgacacgg ttgctccgag 1207321 cgaatcaccg atcagcgttc ggccgtaacc gatctgatag gttggatact catcatctgc 1207381 aaaaggaacg agctcatggg cgatgaaccg tttataagcc gaaaattttg aaccctccgg 1207441 atgataagtg tttctgcgct cttttacatc cttataggga acaccgataa taatgctccg 1207501 gtctatttcg cgtttcgaca gcaattcctc aacctgtctg ccgattctcc ccagcctgaa 1207561 ataatcgtgg ccgtcctgcg cgataatgac atggtattta taaagcgggg agtagttgga 1207621 cggcagataa acaagcaagg tcatttcctc gttaagctct tttgaaaaga atttcttttc 1207681 ttgcactgtg ccgtttttcg gtgccataaa aacattcctc caggacatca ctatactttc 1207741 ttgcattttc aattattgta ccatgaatta ttagaaattt ctctctttaa acggttcggc 1207801 acacgaagaa aaaagtgttg aaataaactg tgaattgcgc taatataaaa caatcagaaa 1207861 attgaaatcg atatttctta tcgtgagagg tggagggact ggcccttaga aacctcagca 1207921 accggcttgt tttgcatttg caaagcgcca aggtgctaaa tccagcaagc gttttttatg 1207981 cttggaagat aagaagaagc gttaaacccc ttcttcttat gaagaagggg tttttatttt 1208041 gaaaagggaa ggtgtcagct atatgtcaca gcacgttgaa acgaaattag ctcaaattgg 1208101 gaaccgtagc gatgaagtca cgggaacagt gagtgctcct atctatttat caacagcata 1208161 ccgccacaga gggatcggag aatctaccgg atttgattat gtccgcacaa aaaatccgac 1208221 acgccagctt gttgaggacg cgatcgctaa cttagaaaac ggcgcgagag ggcttgcctt 1208281 tagttcggga atggctgcta tccaaacgat tatggcgctg tttaaaagcg gagatgaact 1208341 gatcgtttca tcggacctat atggcggcac gtaccgttta tttgaaaatg aatggaaaaa 1208401 atacggattg acttttcatt atgatgattt cagcgatgag gactgtttac gctctaagat 1208461 tacgccgaat acaaaagcgg tgtttgtgga aacgccgaca aaccccctca tgcaggaggc 1208521 ggacattgaa catattgccc ggattacaaa ggagcacggt cttctgctga tcgtagataa 1208581 tacattttat acaccggtct tgcagcggcc gcttgagctg ggagctgaca ttgtcattca 1208641 cagcgcaacc aagtatttag gcgggcataa cgatctgctt gctggacttg tcgtggtgaa 1208701 ggatgagcgg ctcggagagg aaatgtttca gcatcaaaat gcaatcggcg ccgtcctgcc 1208761 gccatttgat tcgtggcttc tgatgagagg aatgaagacg ctgagcctca gaatgcgcca 1208821 gcatcaggca aacgcgcagg agcttgcggc gtttttagaa gagcaggaag aaatttcgga 1208881 tgtgctgtat cccggaaaag gcggcatgct gtccttccgt ctgcaaaaag aagaatgggt 1208941 caatccgttt ttaaaagcac tgaagaccat ttgttttgca gaaagcctcg gcggggtgga 1209001 aagctttatt acataccctg cgacccagac gcacatggat attcctgaag agatccgcat 1209061 cgcaaacggg gtgtgcaatc ggttgctgcg cttttctgtc ggtattgaac atgcggaaga 1209121 tttaaaagag gatctaaaac aggcattatg tcaggtcaaa gagggagctg tttcatttga 1209181 gtaaacacaa ttggacgctg gaaacccagc tcgtgcacaa tccatttaaa acagacggcg 1209241 gaaccggggc agtcagtgta ccgattcagc acgcctcgac ttttcaccaa tcttcatttg 1209301 aagagttcgg ggcatatgat tacagccgct ctggcacgcc gacaagaaca gctctcgaag 1209361 aaacaattgc cgcactggaa ggcggaacaa gaggatttgc tttcagttca ggcatggctg 1209421 ccatctcaac agcattttta ctgctgtcac agggtgatca cgttcttgtg acagaagatg 1209481 tatacggcgg aaccttccgt atggtgacag aggtgctgac ccggtttggc attgagcata 1209541 cgtttgtcga catgacggat cgtaatgaag tggcgcggag catcaagccg aacacaaagg 1209601 tcatttatat ggagacgcca tcaaatccga cacttgggat tacggatatt aaagcagttg 1209661 ttcagcttgc aaaagaaaac ggctgcctga cctttctgga caatacattc atgacgccgg 1209721 cactgcagcg tccgcttgat ctcggcgtgg atattgtact tcacagcgcg acaaaattct 1209781 taagcggaca cagcgatgtg ctctcaggtt tggctgctgt caaagatgaa gagcttggga 1209841 agcagctgta taagctacaa aacgcgttcg gcgccgtcct tggcgtgcaa gattgctggc 1209901 ttgtcctgcg cggattaaaa acattgcagg tccgtttaga gaaagcgagt caaacagctc 1209961 agcggcttgc ggaatttttc cagaagcacc cggcggtcaa gcgcgtgtat tatccgggac 1210021 tggctgatca tcccggcgct gaaacccata aaagccagtc aacgggagcg ggcgccgtgc 1210081 tatcttttga gcttgaaagc aaagaggccg ttaagaagtt agtcgagaat gtgtcactcc 1210141 cagtcttcgc tgtcagcctt ggcgccgtgg aatcgatttt gtcctatccg gcaacgatgt 1210201 ctcatgcggc aatgcctaag gaagagcgtg aaaaacgcgg tatcactgat ggcctgctcc 1210261 gtctgagtgt cggcgtcgaa catgcagacg atttagaaca cgatttcgaa caagcgctga 1210321 aagaaattgc tccagtttcg gttcgttaaa aaagaagccg gggatagtcc ggcttctttt 1210381 attattgttc gtcatcagga ttcagaatcg cgaggacttg atgatcctcc caaacgccat 1210441 taatttttac attttttcgg gcgatgcctt ctttatgaaa tcccgctttt tctaaaacac 1210501 gcatggaccc gagattacgg ggcatcacac cggcttcaat ccgatgcagt ttcaattcgt 1210561 ggaacgcata atcaacaacc aatctgactg cctctgtcat aatgcccttt ccattatggg 1210621 ctttgtctaa aaaatacccg atgaacgcag tttgcagcgc gccacggatg atttgaaaga 1210681 gcgaaaccgt cccgattaat ctatcgtctg acgctgtaaa gatgccaaaa tgatattctt 1210741 catctttctc aagtctttcc tgatactcgg ttattcgttt tctttgcccc tcaaccgtat 1210801 agtaatcgtc tgcgcgtatc atagaaaact gttcgaaaaa atctcgattt tcgctttgca 1210861 gccccagatt ttcttcggca tccgttactt ctaaaggtct aacataaatg gtttttcctt 1210921 ttaacatata gtgatctctc cgttctcatg tcagcattcc tcttacatta ttctcaggga 1210981 aatgcaaata tcctttttat aagaaggaag aaaaccaatt tcccataaaa gtgccaacat 1211041 agttgccgat taagtagccg agcgtaccga caagcatgat cggggcgaca agctcccgcc 1211101 atcccttggc aattgccatc gcagccgcag tcgtcggtcc cccgacagta gcgttgacgg 1211161 cgagcagaat ttcttcaagc cgcacacgga acaattttcc ggcagctaag gaaaccgcta 1211221 aattgctaat cgcaatgata aacacgaata atagaataag aggcgcattc gtgacgatta 1211281 agcggagatc tgcaggaatg ccgatcacca caaaaaacaa ataaatcaaa aaggttccaa 1211341 gctcctgaga tccattgagc ctttcaaaaa aacgcgggaa aagaaaaatg ataagaacag 1211401 ttaaagacgt aagaaccagg tactgatcgc caagcgtacc ggtcagcagg ggatgagaaa 1211461 aaatgctttt aaaataaccg gaaaccttca tactaaccgc aacaagcgcg aaagcggcac 1211521 cggcattaaa agcgatatcc tttaaggaaa tatccttccg tttccaatag ctttcagcac 1211581 tgtttccgct gtttccatcg gcttttacct tctcttcaaa cggcatggca taatgccgct 1211641 gaaaccattt gagtgcagga atgctgatta aaataaaaaa caaaagcgcc atcataaaat 1211701 tatcagccac aacggtagcc gacacatatt caccaggcgt ctcaaatttt gccgccatcg 1211761 ccgcaaagtt gaccccgccg ccgatataag aggcgctgat catcccaccg attttatcta 1211821 agtaaggaat atgctgtttg agtagaaaaa aagccaggat actgccaagc actgttccaa 1211881 cggagctaat cagaaaaata aacagcaaac gcctgctttc cttaaaaatt tgcctaacat 1211941 tgatctgaaa caataaaagt ggtatcgcca gcggtaccac ataagaccac acagtgtcat 1212001 acacgggcga ctcaacagga agcactccta catttgtaaa caccatagca cctgcaaggg 1212061 cgataatagc gcccgacaca gcagacgccc acttaaagcg ctgctccagc ccgatgctca 1212121 ctgccgccca caccgcaata aacccccata atacccatac atcatcagaa gaaatcaaag 1212181 aatgcaaaac cccatcacct ctattgttag aaaattaaga catattataa tagccgggga 1212241 acggaacagc aagtccaaaa aaagtttttc taaaaaagca gttgacgaat agaaggtaag 1212301 gttatataat agaacttgtc agaaagataa caacataccc agcaacacat acatatcatg 1212361 attccgtagc tcagctggga gagcgctacc ttgacagggt agaggtcgct ggttcgagcc 1212421 cagtcggaat catagcttaa acccttgcgc agcaagggtt ttttactttg cgttaataaa 1212481 gccggttcgt caaattcgtg agttgttggc gaactgttgg cgaaattcat tgaccgcagt 1212541 ccaaaaacta cctccaaact tacttgatta gttcaatagt aacaaacgga agatcggatt 1212601 tctgttaaat cttcattgag aatagccagt ccaagaccgt cacttcagcc atgcatcttt 1212661 taaatgaaat tttgtactga aaacatcaat tgtattttta aattctgctc tagaatcagc 1212721 ccctttataa taatcttgat aaattgcttg gggtgatact gattcgtgat ttgtgctatg 1212781 gtttgcaagg cttgtagcaa aagcaggagc aacagtaacg agtaaagcaa gggataatgc 1212841 aaaaccagtt aaagcttttt caatttcatt ttaagcactt ctttttttaa aatacaactt 1212901 tattattaaa tggaatacaa aaacatccaa ggtgtttttt tgttagtaag ttgagttagg 1212961 gggattggat ggcacttaga atattgtttc tgctgatggg atgttgattc tggatatatt 1213021 tccaacacga ttacaggccg gacatgaaag cgaaccttgc tttgatcggg gcaatcattt 1213081 catttacggc tgcggtttac tttaaagata ttgatgtatt gagagaagag ggaaaacaaa 1213141 tgaacggaat ttctgagcgt tggaacacgt ttaaattaca aaaatcccct gaaccactct 1213201 agatcagggg attgctttcc caacagctta ttaagtagcg gaaggcatga tcaacgattt 1213261 agtatcaatt tattaattgc gaatactaga aacataccgt tttccgcctt ccttagaagt 1213321 aacatattct cgaggaacat taagtctatt ggtagaatga taacttacat aaagtttcat 1213381 atttgctcgg ctcgttacga tagccgtatg atccatccaa ccatcagcat agcgaagacc 1213441 tattttatta tggtaatcat agtgatatac atctccaagc tttacatttg aatatgtatc 1213501 agaaacagtc ttcattttta ttccgccagc ttttaaaatg tatgatctaa aggctcctgc 1213561 attaacccaa gcatctgtat agggtttcca ttctttaaag tacggcattc ttccagctct 1213621 taatgcttgg gaaacaaagt tagtacaatc tttgtcttta taatatttat agtttttatt 1213681 tggttttaag gcatattttt ctgcatattt cattgcagcg taaccactat atcctttaac 1213741 agatgttgca gtcacagtta gttgattaga gttagcagca ttgaagttca tacttactgg 1213801 tttatcttca cttttcactt cttctttatc atcatttttc acttcttgct tatatttttt 1213861 taaaaattca tctaatttaa catccgaaga atattcttca tcattttcat attgtagagt 1213921 tgaagaagaa ttatttaatt gtgttacatt tagttgctta gaagaattac tcaatggtat 1213981 tacatttagt tgattagaag aatttttaac ttgagagaaa cttagattag aagtatttgt 1214041 tgattgagaa ctttgtttat tagaagttgt tttgggaatt tcaagtttaa tattatcgcc 1214101 cagagatgtt gttacttttt caacaccaaa aacaaagttt cgagtaatat aagcttcaac 1214161 aattagctta ttgttttttt cagaagtctt aacatcgtct atatcgtatg taaactcgtg 1214221 gaatttttgt ttgtccactt tacttaacgc agaatacagt aagactcctt cgtcggaatc 1214281 agtcaattta gactctttag gatgcgctaa aggagtgttg tgttcaaaat catatttttg 1214341 ttgttctaac atatccttaa ctttttcgta accaatctcg ttggtaattg aaacattttc 1214401 tttagtctct ttattagtag tggctgcaaa aacttcattt gttgacacta atggtgacaa 1214461 tgatagacat aaaactagtg aagcaagtaa ttcttttttc atacgaaacc tccaataaaa 1214521 tctaaatata agtaatattt atcatttaca ccaattgaaa tatggcataa aatacatgta 1214581 ataatataac ataaaaataa atacataaaa aggtatcgga ggaaaaaatg aaaaagaaaa 1214641 ctaaaattat actttctctc ttggcagcac ttattgttat attgatagta cttccagttc 1214701 tatctcctgt tgtctttaca gcttcttcgg aaaaaggagc aatcagacac gaaatttata 1214761 aaagaggata tccctaccaa agctactttg cagttctcca gaaaagagaa ggagacaatg 1214821 aatctgggaa tctttattat gtaaattggc tagattggaa agatgaaaca gggcaaactc 1214881 ctcacttatg ctattcgaaa aaatcatcag atggtgaata cgaagtaagt tgtggcacag 1214941 ggccgtaaaa ataaatttta aaattgaata agtccaagac ggaaagcctg cggacactga 1215001 tcgttttaca gagaaatttg tgcttcgatc ggtgtccgtt ttttttcgca actaaccaga 1215061 tgtctatcgc gattactagc tatgaaagga gtaattagac atgaaacagt ccaaaaagaa 1215121 accatcacag aagcaacatg agcgcttaga tcgtttctgg caacaaatga tgaacactaa 1215181 catgcaaaca ctcagacgtg gcaaaggcgg cgcttataaa cgcagaaagt aaaaagggag 1215241 tttgaggatg atgaaaaacg gattcgctta taaaaacgga aagcttgtga atatcttttg 1215301 cggcaaagaa gagctctata acgagttgaa agccttcttg gtcaaaacct tcagtatcaa 1215361 cgtgaaagag gtatcgaggc cctcaatata tcgcagaaca aaaagcaaac aactggaatg 1215421 acacttactc tatttaacta tcaggaggga aagcactatg acagatcaaa tgattgcatg 1215481 ggagattgag gaatggattc gtgattataa attcatgctg cgggagatca aaaggctcaa 1215541 ccgtgtatta aacaaagtgg attttattag cacaaagctc actgcaacat acggggagga 1215601 agcgggcatg ccaaggggat cagcaggcgt cagtcaggca gaattgcggc agatggaccg 1215661 aagagaaagg cggcttcaca aatatgaatc tattgtgcat tacctggaca atgcaatgga 1215721 acacattgaa gaagaaaagc accgaatcgt ttacgattgc atgatggaag gcatgagcta 1215781 cactgctatt gcaaaccacc ttgattgctc ccgggatacc atcagaaaga tcaaaacagc 1215841 cataatcggc aacatcgtca ataaagtcaa agaagccaac tttctgcaat atttgaattc 1215901 gtttaaatcg gcggtgtaaa atggggggca ggatcggcgc ggcggattat tcctgcgtca 1215961 ccaccaattt catacaatga gtaaaacctc ccagtggtaa gcgaggatca actcaactgg 1216021 gaggtcttac atagtgaatc ggtgataaaa cagcagcagt attgcgtaca tgttaatatc 1216081 cccgacaaaa tatgtttttt tcaacagatt cgttcgacaa attttgcaaa ttgttaatcg 1216141 ataacttttc attcccgata ttaaaaatgg gagtgaattg taaaatgaaa aaacagaaaa 1216201 ataataaaaa gaagaatatt gaaaagcgaa atattgaaaa gcgaaatatt gaagagaaga 1216261 ataatgagga cttagaagaa ctggaaaatg cgatttatac ttatcacaaa aaggagctac 1216321 ttgctttctt tcttgaaaaa actcgaattg gtcatgataa ggaagaatac aaaaggttcc 1216381 aatctcttct ttataagttg gatattgaat gtttagaatt tgctatatcg agattttctc 1216441 atatagatat tatccatgat cattcaaaat atgttccagc ctttatccct ttatttgcag 1216501 catatctcac catgttcttt aatttttatg aaaaacattg gggagcttta tcttttgctg 1216561 ctggtacaat tgctgctatt gtttggataa ttgcagtaga aagaaaacat agaaatcaag 1216621 caatttctat tatgaaaata tttgaacaag tcaaagagag aaaagtgaaa gacagatcta 1216681 aagactgaaa ggagaaaata tgaataagga taaattaagg tatgcaatct taaaagaaat 1216741 ttttgaaggt aatacccctt tgtcagaaaa cgatattgga gttactgaag atcaatttga 1216801 tgatgctgtg aactttttaa aacgcgaagg gtatatcatt ggggtccatt attcagatga 1216861 tagacctcat ttatacaaat taggacctga actgacagag aaaggtgaaa actacttgaa 1216921 agagaatgga acatggtcta aggcctataa gaccattaaa gagattaaag attggattaa 1216981 ataataagag catcctgcgg ggtgcttttt ttgttccctg taaactgctt ccggtaagtc 1217041 tcaggataga caattggcgg ttaacggctt gagcacggtg gtggtttaga gggaatatct 1217101 tttccaaaac aacacgaatc agaagggggc ggcggtgaat gtagatggcc gaaaagcaca 1217161 ttcaggcgta taaggattac gtcaaaggca tgaaatacaa ggaccttgcc gagaaatacg 1217221 gggtgtcagt gaacaccatt aaatcgtgga agcagcggca tggttgggaa aggaaaaagg 1217281 gtgcacccat tgaaaaaagt gtgcacacaa aaaaaggcgg gcaaccgggc aacaaaaatg 1217341 cattagggaa caatggcggc gcaccacaga agaatcaaaa tgctgtgact cacggctttt 1217401 tctctaaatt cttgccagaa gagacgcttg aaatcatgga agagattcag gagcgttcgc 1217461 cagctgatat gatatgggat cagatacaga ttcaatatgc ggccattctt cgggcgcaaa 1217521 agatcatgtt cgtttctgat aaggaagaaa tgatcaaaga gctgaaaaag aaaaggtccc 1217581 tcatatctga ggtcagcgaa attgaagatg ggcttgtcat tagttttagt acgtggtttc 1217641 gctacagact ttacagtgaa acaaacacct aacacatttc acattgcttc agattgcctt 1217701 caaacttgat aatataactt ctaaaccttc ctataaaatg aaggtttttt atttgatttc 1217761 aatttttaaa tcctttacat acagcgattg attaactcga gcaatcaatg tcgcagttat 1217821 atttattttt caagaaaatg ttataatgaa aagccataaa atgatgggag ggggaatttc 1217881 gatgcattac ataacggcat gtttaaaaat catcagtgat aaagacctta atgagataat 1217941 gaaggaattc aaaaaacttg aggaagaaac gaacaaagaa gagggttgta ttacattcca 1218001 tgcttatccg cttgagccat cagaacgtaa aataatgctt tgggagattt gggaaaacga 1218061 agaagctgtg aaaatccatt tcacaaaaaa acacacaata gacgttcaaa aacaagaatt 1218121 aacggaagta gaatggttaa tgaaaagcaa tgtgaatgat tgaaaggctc tttaaaaaga 1218181 gacattcaat gacttagtat cagccacttg tgactaagta gtaaattgtt gtccaactct 1218241 tattttttct atttaatatt ttttgagacg aaaatgtttt tttaagctga ttttaaaatg 1218301 tattcaaagt cagctctgtt tgatttaatg gattatatta tttggatagc ttgttaccat 1218361 cataatggag atactcctta taaattggag gttaaaataa tgagtcattc tcaagaaaaa 1218421 attgcactaa ttacaggagc aagcagtcaa ggggatattg gtacggctat ttgtcgtaag 1218481 ttagcctcac agggtataca tatcttcttt actcactgga attctgatac ggcctggata 1218541 gaagaatttc aacaagaaat tttacgtatg ggtgtccgct gtgaggcaat gaaaattgat 1218601 ttatcagatg cacatgctgc attcacaata catgaaaaaa tttcagataa attaggatat 1218661 ccttccatcc ttattaataa tgcagctcat tccgcaagtg ataattatgt atcgttagat 1218721 gctaaatcac ttgatgagca ttatgcggtt aatatgagat cgaattttct tctttgtgtt 1218781 gaattcgccc gtcggtttaa aaaatctaat ttaatatcag gaagaatcat caatatgaca 1218841 tcagggcagg atttaggtcc tttgcctggg gagttagcgt atgcagcaac taaaggagct 1218901 atttctgcat ttactaggtc gttatcacaa gaacttgcac cattgggcat cactgttaac 1218961 gccgtaaacc caggtccaac agattctaca tggatgacag atgaaataag aaattttctt 1219021 tcacctaaat ttccaatggg gcgtattggc acaccagatg atgcagcacg aatgattgcc 1219081 tttcttgcaa gtgatgaggc tgaatggata actggacaaa ttattcattc agaaggtgga 1219141 tttattcggg gctaagctaa tgaaacacgg tatacaccaa tgtatgatgt attcccaaaa 1219201 ctaaatctaa acttgaagcg aaaataaggt cccttctctt tttagagggg gaccttattt 1219261 tattcatgca tgttttgcat ccagaaaatc tggcggataa agattaataa accgttacat 1219321 atacttttcc gaatactgca gtacctttaa acaaagtaat cgtggctttc ccttttgatt 1219381 tagccgtcac taaaccattt tgatcgactt cagcaacttt ttggttatca gtccaataac 1219441 gagtagctga attattttta acagaatagg tttctccaac ttttagaggt aaattatagt 1219501 cttgaatctt gataacatgt gtaggtgaaa tagaaatgtt ctttacttca gtaggtgtgg 1219561 agtttatttc atgagctgaa gctaccccgc tgaccgacag agctaacgca gaaatcgata 1219621 aagcagaaac aaccgttttt ttgaaattca ttttgaaaca ctcctttaaa gttttttgtc 1219681 ttgcactata acaattcaat aaaagtaatt attttccttg taaataaatg ttaataatat 1219741 gtgaacgatc aattgatttg agctaagaat attgtgtgcc ctgcacagag tttgtattta 1219801 tgatggaaaa ttgctgagag agaatggcca tccttaaaat gttaatagca cacatttgat 1219861 gggtattagt ttgttgagcg tgtggaaatt ttgttacctg cactttatcc ccgaagatac 1219921 caaatcactt ttcttcatca tgttcttact ttcgtactca tacattagaa aatcttcgtt 1219981 ctaaataggt gaagaattgg agtattttta tgaatttctg ctgaatatac attacatagc 1220041 aaactcaaag agtataaaaa tcgctttttt ccggaagctt cggtaaaaaa cgaaactttt 1220101 gtctctatga ttttgtttta taatgtaaac ggtttcttat atagtatact tatactatca 1220161 atttgctcaa gtagatactg acaggaagga tagaaaaaca gatggaatac ataaatacaa 1220221 gacaaaaaga gattttgtat ctgttgttat ctgaacctga tgactattta gttgtgcaag 1220281 atttcgcaga tagggtacag tgttctgaaa aaacaatccg gaatgatttg aaagtgatcg 1220341 aggattatct caatgagcat tctcatgcac agcttattcg aaaaccaggg ttgggcgttt 1220401 atttacatat agaagaacag gaaaggacct ggctaagcca acaattacat actgaacatt 1220461 tttcttctag gcagcggagc gataaggaaa gaatgctgca cattgcttat gacttattaa 1220521 tgaatccgaa gcctgtttcc gcaaaagaca ttgccgctcg gcattttgtc aatcgatctt 1220581 ccattaaaaa ggatttatac gcagtagaag agtggctgaa gcgttttgat ctcacactgg 1220641 tttctaggca gcggcttgga ttaaaggttg aagggaacga aagaaataaa agaaaggcat 1220701 tggcaagaat atctgatttg attcacaata cagcgtttac cagccaattt attaaaagta 1220761 agtttttaca ttatgaagta gactttgtga cgaaagaaat caaatcacta caaaaaaagc 1220821 attccctcta tttcacagac gaaacgtttg aaagtttgtt gctgcataca ttgttaatgg 1220881 tccgccgcat caaaatgaag cagccgattt cattgtcccc aaaagaaatg gcggcagtaa 1220941 aaaagaagaa agaatatcaa tggacatttg cttgtttaca gcggcttgaa ccggtttttg 1221001 caattcgctt ccctgaagaa gaagccgtgt acttaacatt acatatattg ggcggtaagg 1221061 ttcgttatcc attgcagaca gaagagaacc ttgaaaatgc tgtgcttcct aaggttgtag 1221121 ggcatttaat caatcgtgtt tcagagctga aaatgatgga ttttcacaag gatcaggatt 1221181 tgatcaatgg tttgaacatt catctcaata ctgtgctaca acggctgagc tacgatcttt 1221241 ctgtagcaaa tcctatgctc aatgacatca aaaagatgta cccttatttg ttccacctca 1221301 tcattgatgt tttggaagac atcaatcaaa cttttgatct tcatattcct gaggaagagg 1221361 cagcatattt gacattgcat tttcaggcag cgatcgaacg gatgcagggc agcagcgaga 1221421 cacataaaaa ggcggttatc gtctgccaca tggggattgg gatgtcacaa ttgctgcgga 1221481 caaaaattga acggaaatat caccaaatcg ctgtaatggc ttgtattgca aaggccgatt 1221541 taaaggatta tatcaaaaag catgaggata ttgatcttgt catatccacc attgcgctgg 1221601 agaatataac ggttccccat attgttgtgt ctccgctttt agagcctggc gaagagaaga 1221661 aattaagtgc gtttatacgt cagctgggcg aatcacaccg ccaaaaacaa aaaacgtttc 1221721 agatgctgaa caatacgact ccttttttgg tttttttgca gcaggaggcg gagcatcgct 1221781 acaagttaat cgaacagctg gcgacagctt tgtttgagaa aggctatgtt gataaggact 1221841 atgcggttca tgcggtgatg agggaaaaaa tgtcggctac aaatattggg tcaggcattg 1221901 ccattcctca tgcaaacgct aaatttatta aacaatcagc aatcgcgatt gccacattaa 1221961 aggagccgct tgaatgggga aatgaaaaag tttcgctcgt ttttatgctg gctgtcaaac 1222021 acgaggatca aactatgaca aagcagctgt ttagcgagct ttcatatctt agcgagcagc 1222081 cggccttcgt ccagaagctg acgaaagaaa ccaatgtcat gacattttta tctcatttgg 1222141 attattaaaa gcagggatta ttccttgctt tttttgttca tggcagggct tgagaaataa 1222201 atttgcgagt gaagacgcct attctccagc aatgatctaa ataaaataag agtttaatag 1222261 ttggagaaga aatgttacac tcttttctgt atatggtaaa gaatgaaaaa acacgattcg 1222321 gttggtagtc cggatgcatg attgagaatg tcagtaacct tcccctcctc gggatgtcca 1222381 tcattcttta atatctttta tgaggaggga atcgttatga aattaacgat ttactacgat 1222441 ggtcagtttt gggtaggcgt tgttgaagtt gtggacaatg gaaagctaag agcctttcgt 1222501 catctttttg gcaaagagcc gagggattct gaagtattag agtttgttca taaccaactt 1222561 ttgaatatga tggcccaagc tgagcaggaa ggagtgcgtt tacaaggcag gcgtcaaaaa 1222621 aagatcaatc caaaaagatt gcagcgccag gtttcaaaag agttgaaaaa cgccggagta 1222681 acttctaaag ctcaagaggc gataaagcta gagcttgaag caagaaagca aaagaaaaaa 1222741 caaataatga aagaacaacg agaacatgta aaagagcaaa ggtatatgct caaaaagcaa 1222801 aaagcgaaaa agaagcacag aggtaaataa tccaaacaaa agcaggcgca gtgcctgctt 1222861 ttgtaattaa ggactctact ttgtaacata tatccaatgt ttatactccg ctgatttatg 1222921 attcaatata aaccctaact tctccaaggt tttttgtgag cctagattat catgttcgca 1222981 tcttgcggtg atccgggata ctgtttctcg gcttaatgcc cagtttatta gtttttgggc 1223041 ggcttccaca caataacctt tgcggcgatg acttttattt gttgcaaaac cgatttcaat 1223101 catgccattt tcgtctgggt cacctaaaaa tccagttccc ccaacaattt cataattgtc 1223161 cttctttaca ataatccatg aatcaaatcc ttttgttcca ttgtttttga ctaaaatctc 1223221 gcggaaataa ggtatcgctt caaaaaaatc agaatttggc cattcaccat ttgtttcata 1223281 gcctaattct ttgatagcct gatgatcttg tttagacgcg gcgtcaagaa ggggaatatc 1223341 aatcgtttgt aatcgtaatc gattcgtttc aaggagaacc atatatttaa tcctcttttc 1223401 tttttactgg gaataatgat aacatataac aattttctct ggtaccttgg cagtagagaa 1223461 agatgaaaaa attgaggggg attgaaagag tgacaggtga gagtttgccc agaccaaaaa 1223521 cgggtaggaa aatgctgatg ttaatgtgtc cctacccgtt tttctgttcc tgaatgcagg 1223581 gtttctgata acatgttgtg ctaccttttc gcaatcaaat aaagcgatat ggctctttgg 1223641 gtttgcacag gattatgaat gataatgacc cattggtttc ttcgtcttgg aaagcttgct 1223701 accgcataca atggagcagt atcgcgcgga gtgaacccac catttatcac gttgatatct 1223761 cttccttcaa gatgacaaac taagtattca cctggattga tgacctgttg gttcgtccat 1223821 gcgtaagaat aaaagccgtc tccaagatct tcggtggaag atggggggac aaagccatct 1223881 acagtcaatg tgatttctct tcttcgctgt ctttctgaaa agtctggact tctttgaggg 1223941 ttatgagtat gtgaaaagta aggaattaac gcagggccat aaaagtaatg atacaaagca 1224001 accactcctt tattttccat tcatacaaat tgtatgtggg agttatttgt tcattcctgt 1224061 tttgttccat gtagactaat aatgggctat aggcgtccaa ggaaatcaat ttgtccttcc 1224121 gttgattcaa tgctagtaac cttgaaaatg caggttagga tgatagaatt tacatattac 1224181 tgcaagaagt tagacataca tcattttgat agtgggtgaa aacaatggcg aaaaaaatgg 1224241 caaaaacaaa tgcggttcgt ctgatagaac agcagaacat ctcttatgag gtattagggt 1224301 ataaaacaga cggccagccg gtagatggca tctctgttgc ggaaaaaatc ggttattctt 1224361 tgaaatatgt atataaaacg ttggttgcag cagcaggaac aaatcattat tatgtctttg 1224421 ttgtacccgt tgcagaagag ttagatgtaa aaaaggcagc aaaggtgaca ggggaaaaga 1224481 aaatagaaat gattgcaatg aaggagctgt tagcggtaac tggctatctt cgcggcggct 1224541 gctcgccaat tggcatgaaa aaattgttcc cgacctatat tgatgcatct gcagaaacgc 1224601 ttgattttat tattgtcagt gcagggaaaa tcggtatgca gctaaagttg gcgccacaag 1224661 atttagccag atcatgtgat gccgcatttg cagaaattgt atagatgcag atatagggga 1224721 acgaaaaagc ttagtcatat cgattaagct ttttccgcat ccctttcaaa tatgatttca 1224781 aaataagcag ctgccccata cccatctata ctgggagcga aaatctgaac gaatctccag 1224841 cctcttttcg cataatcatg gatgatttgc tggtagtctt ctttaggcct tcttctcatc 1224901 gtactcagct caactcttac gaattcatat tctttcatcg tttgatccct cctattaagg 1224961 tatacgtaaa atggagcgag aagttccgaa aacctaggtt aaggtcggaa agtatatttc 1225021 actcactaaa caaatccatt tatgcctgat gcctgcatgc atctgggaag agttaagggg 1225081 ctataaaaac gaattttacc gggtcagcag tccaaatgaa tctcttgctt attgcatttg 1225141 actgagtata taagtaaaaa aagagcggcc agaacatata agaaggagat gatcattaac 1225201 gcactcataa cagggtagtg tttagcggag tagatgaaaa aatcaagctg tgaaatttgt 1225261 ttggggctgc tgacggcatc aattccatta agcagttttg agagtttagc agtatagttc 1225321 caatcaaatc gatctgaaac aagctcgctt ccttgatacc aattaacagc agctaaaaac 1225381 agaaatacca taatagaaaa tccaagctga acaactaaaa atattccctt cacttttgta 1225441 tgacctccaa atctatgaat atgggaaaat caaacaatat attaccaccg tatgggttat 1225501 tcttgcaatt tcacttccat acaactcaaa cgcaagtcta tttttttgtt tgtttttggc 1225561 ttataatacc tgatgatgga aaaagagtgc gggtttatag attagagaaa caaatgtatt 1225621 tcttagcatt ttttatttgt ggagagagta tagaagcatt cgattagatc tgctttttca 1225681 cagaaacggt tttcatctgt ttgcctgagc tttacaattg gctggcaaaa aaacaatgat 1225741 ttctttcaat caaaacatgc aacgatgcga cacattttat atcttgatga cttatttcat 1225801 tgcctttaag tcatcctatc gagaaagcga tggtatttta tgaacaaaga aaccctaaaa 1225861 aacatactca tgattttttc aatatgcgca acactccgag aaaccgatgg tatgcgcata 1225921 gctgatagct ggattttgag tgagattata cgatttttga tttgcatggt tgtgtttttt 1225981 gccatgacat ttctattaga tgctgttttt ccaaacaaaa aagagtcaca ttaatgtgtg 1226041 gctctttttg catcatctga tcagaaacat cataaatgaa tcgatcatca tgatgaagaa 1226101 cagcaagcaa aaataaataa gcgagtagac aaacatatcc tttgcccact tcacgtcatc 1226161 gtctgttttg aatcctttga tgcttttttt gatccatatg cctccgagaa ccaaggcggc 1226221 taagaaataa aatgggctta tatggccggt gccgagagag aaaggaaata atagcgtgac 1226281 cggcaccagg acggcaatat attgcatcat ttttattttt gttacatgat tgcctttgac 1226341 tactggcaag agcggaacgc cagcagcgcg atattcctct ttgcgtctta tcccaatcgc 1226401 ccaaaaatgc ggcggctgcc acagaaacat aatcgtgtac aacagcactg ctgtcatact 1226461 gaagtcaccg gttacggcac aataccccat caatggcggc gcagctcctg ggaagctccc 1226521 gacaaatgtg ctccacacag acgttcgttt cacccatacc gtatagatga tcgcataaaa 1226581 aataaaggcg gccagtccga gaaaggccgt taatggattg agggaataaa gcatggcaag 1226641 acctgcgatt cctaaaacag agccatatgt taagatcatg gctggcggca ttttccctgt 1226701 gaccgaggcc ctgctgcgag ttcgtgccat ttttgcgtcc atatgccgat caaaatagtt 1226761 gttatagaca gtgccggaag ccatcacaaa cgcggttccc aacattgctg ttaccattgt 1226821 catcaaaaaa gccaagccgg ttaacgtttt ttctgcgctt gcaaacgcga tccaaaaccc 1226881 gccgaaggct gctatcgagt ttgatatgat aatgcccggc tttgcaagtt tgataaaatc 1226941 gtaaatggtt acccggttcg aagcttttat gtattttgtt tcagatatgg ctgcagaatc 1227001 tcttgtattc tccaaaaata gacgcctccc ccaaaactgc atgcttttgt tatcgtaaca 1227061 agagggggac agaatcacaa ttatttccca tatttgtcat gatattgtca tttttaaaac 1227121 aaaaaaatgg ggagctggac tgcccccatt ttgatatgtg gcgactagta accgtaacct 1227181 cccccatatc ctccgccata acctccgccg taaccgtacc aagggtagta aggcggtcgc 1227241 gggcgcgggt agtaataagg cgggcgcgga taaaacgggt agaacggata atacggtctt 1227301 ggataataat aaggcggata aaatggcggt ctcggacgcg gataataata aggctgtctt 1227361 tcatcataag gggtaatttg ttcaaatgac tgttcattca aagggtaatc caagaggaaa 1227421 acctccctag ctttttttat tccttttacc atattcctga tgcttaagtt gggtgtatgt 1227481 acattcatga aattcggttt tttttatgat gaaattcctt aaaaaggatt gacatgaact 1227541 tctaaatctc atagtattac aaatgtgaaa taaatgttac tacaatgtta caaaaacatt 1227601 tctaaataga tacagttcca actgatgaag agtaaatcga aatggctacg aaagaaggag 1227661 tttttgttgt tggcaaaaag aatcaaatgg tttcatgtat taatagcagt tgtatgtgtg 1227721 gtgggcctta tcggcttttt ccataatcat tcattgaaaa aagaaacggt catgaataaa 1227781 gtaagaactg attctcaata tgggaatgtt gagatcgcaa cgcttgtgaa tgacgggaaa 1227841 acttttaatt acgcggtaaa ctatcctgtt ttcaaaaatg aaaaaatgga ttcggcatta 1227901 aaaagattcg cagaaaaaga ggttcgtcaa tttcaaaagg aaacaaagga cgttgaccaa 1227961 gagcatacga caaaacgcaa cgaattaaat gttgattata aaattgtcca ttatgccaaa 1228021 cagacagtgg cgattgtatt taatgaatat aaatacatcg gcggggcaca cgggcaaacc 1228081 gtgaaaaaaa cgtttaacta tgattttagt aaacaagcgt ttctttccat tgatgatatt 1228141 ttcaaagagg acgctgacta cttacataag ctttcgttaa tcgcttatca cgagctgaaa 1228201 aagaataagg acattgccgc ggacgatgca ctgttaaagg aagggacggc tccgaaaaaa 1228261 gaaaatttca gccgctttgc catcaaggag gattatatcg aactttactt tgacacatat 1228321 caggttgcag caggctatct tggagagcaa tcgattgcca ttaagaaaag tcttttgaaa 1228381 gacattctga aagaacaata tattgataaa gcaaaaaata aaaataaaat caaagaacaa 1228441 aagccgaagc atgaagtgat ttctttaccc aaagaggaaa cagttgatcc aaatcaaaaa 1228501 gtcattgcgc ttactttcga cgacggcccg aatcctgcga caacaaatca gattctagac 1228561 tccttgaaga aatataaggg tcatgccacg ttttttgttt tggggagcag agttcaatat 1228621 tatccggaaa cgctaataag aatgctgaaa gaaggaaatg aggttgggaa ccattcatgg 1228681 agccatccgc ttctcacaag gctttcagtg aaagaagcgt taaagcagat caatgatacg 1228741 caagacatca ttgaaaaaat aagcggatat cgtccgacgc ttgtaagacc cccatacggc 1228801 ggcattaatg atgaactgcg gagtcaaatg aaaatggatg ttgcgttatg ggatgttgac 1228861 ccggaagatt ggaaagaccg taacaaaaaa acaattgttg accgtgtcat gaatcaggcg 1228921 ggagatggaa gaaccatttt gattcacgat atttaccgca cctctgctga tgcggccgat 1228981 gaaattataa aaaagctcac cgatcaaggc tatcaattgg tgacagtttc tcagcttgaa 1229041 gaggttaaaa aacaaagaga agcgaaataa attagaaaag gctgtccgta cggacagcct 1229101 tttttctatt taataagagc ctgtggtggc ccaaacattt aagtttggtc ctgaatactt 1229161 gccgaaagcg taagaagtcc ttggatctaa atcatatacc atcggtgtat agcaagactt 1229221 ttggccggcc accgcttttc cattgccgcc tgcagaatca caattatatc tttttccgtc 1229281 tgtgttccgg gtaatctccg catttgcttc atagccagac gtcaatgtat tattcatcgt 1229341 gatttttgcc caagccgttt tacatgtact gctgaattta agctcgacta ctccgatgac 1229401 ttgattgctg gcattcacta agtttgagga tttttttgta gagccgctgg acgcacaatc 1229461 attgtaataa gggctttttc catcgtaggc atgggtttcc gccttggcgg gtgcaccttt 1229521 gacggcaaaa acaaatacta ctgcgaataa caccaatgaa gccttcataa acagtctttt 1229581 caatttatga cctccttaat atggcaaaca ataaatcata tggaggaaca atcaaaacat 1229641 gcatgctttt ttgtgaacaa taaaggcggc cgggaggatg gagttcttgg ccgcctctgg 1229701 tatgaggtta tgcttttaca tcaatggttt gtccgagagt tggatgttga atcatcttta 1229761 aggtttgatc ggcattttgc tgggcggtgt ccagcctttt tttcgttaaa gcaatattta 1229821 cattctgggc aagggatgct tgatgcatcg caaccgataa agcaggaata tccatggttc 1229881 cacctcctat gccttaccta tcggcgggtt tgtatgattt tacagtgaaa aatggcttaa 1229941 tttctcttgt tgacccttac gctgcggcat atcgtatgtt tttgacaagg agggaatcag 1230001 gatgaatcta gtaatggaaa agacctttga gcaatacgaa aagctgtttt caatggaaga 1230061 acagaaaaga gaagatgtat ttcggtatac gatgatgagg ccgtttgaaa agatgtggac 1230121 cgccatccaa gttccgctga aagcgaagga gccaaacggc tatgatgtga tcatggctgc 1230181 gaaaatgctg ggctatttgg atgtccgtga tgctgaaagc ggccagaaag cactacaaat 1230241 actgaaagaa tcacatgttt cagagacagc tgaatctgca cttcggcaat gcatattttt 1230301 tgctgagcgc gaacagctgc gggtgaatgc aaaggagatc aaattcggcc tttatatcgc 1230361 tgatccaaat aagcttcagc tgcaaaaagg ctactgcggg tttggcggga taccgggctt 1230421 tattcatgta tggattaatc cgaacagtta taacctgcca aggattcctt ccattattgc 1230481 tcatgagttt catcataatg tgcggttttc gtatatagat tttcatcatg gctctgtaag 1230541 tgtcggggat tatcttgtga ttgaaggatt ggcggaatca ttcgccagag agctgtttgg 1230601 tacggaacga ttgggccctt gggtaactcg ttttgatcat gaagacttgc aatattccat 1230661 tgatgtgatt aatgaggtgc tggatgtgaa aggattttcg gaagtcagcc gttatatgtt 1230721 tggtgatcca attgctaacg accaaggctt taagcctgca ggtttatcgg cttttgcggg 1230781 ttatgcagtt ggctatcatg ccgttcagtc atttatgaat caacatcata tcacgataag 1230841 cgaggccaca cgtttggatg cgaagaccat tatttctcaa tgcggtctgt tttctacatg 1230901 aaaaaagcgt cacatacagc ggcgcttttt gattcccaaa accagcagtt ctatggcggc 1230961 acaggcggca attccgattg tatatgcttc gatatcgctc cataaaaaac cgtaccctag 1231021 tacaagcccg ccaagagaag tatctctaat ctggtcgatc cattcggcat gatagagctg 1231081 gctgaattca atgacaaaac agaaagaaag actgataatg cccgttatca ttgtcttcag 1231141 cttccgaaat agaaatccgc atcccgtgaa gatcatggcg gcccacaacg agtctcccag 1231201 ataagtattg agggtatcag gaagaacact ggagaatgct ctggatccaa gccccagccc 1231261 aatgatcagt atggtgaaaa ctgcatatat ccaacgattt cgcttcattg cgaattgata 1231321 ccccgtctct gcttcatctc cctgtattgt aaggaatata gcttttattt gtccactaaa 1231381 aaagcggctg aatagccgcg tagggtgttt attttgcttt taggtttaca tggtcggctg 1231441 tctgatccgt gcctattaca aaatggagtt catagcggcc tgtatcatat acataatcga 1231501 tttcatcggt aaacgggacg gttaacaccc gatttactgg tcctaattgc ttctgcagca 1231561 cttccggcgt aactccgcct aaattcagct gccgttccac accggttcca aagtagcgga 1231621 tttctgaaat tgtcatgtct ttatgatagg aaaatccgta gcccggctgt cccatattcc 1231681 agtgatataa atcaaatcga ttgtctcccc cgactggtct ttccggttcc ccaaacgcag 1231741 cgtggacatc cccttttgtg cttttgttaa tggtaaggcc ttgcgcctgc tgaggcattt 1231801 cccctttata ggcggtgtta tagaggtttt tgacaagctc agcggctgat tgattcgtgt 1231861 tttctgagag tgtgtttgtt tgagctgcgg cctttgccgg tgctgaaaag gacgcagccc 1231921 caaagccggt aaaacagctt gttactgctg ctgccgcggt tatagcagac attgtctttt 1231981 tcatgttaat ccctcctaat tgatctacca ttccgtttcc ccgtgttttt gcaacgaaac 1232041 atgtgagtgc gctttgtatg ttttattgag ttgttgtaag ggaactgaaa taggtaattc 1232101 ggtatataaa gcaagaaagg ggaatggaga tggctggcaa gaaaacaatc acaataaacg 1232161 gcgttgaaat ggaagcgtcc gaggaacaga cggtgctgca gcttttgaat aacagctcga 1232221 ttgaagtgcc gcaagtttgc tatcatccaa gcttagggcc gattgagaca tgtgatacgt 1232281 gcatcgtcag catcaatggt gagctgaaga ggtcgtgctc cgctgaatta aaggatgggg 1232341 atgtcattga tacgctctca cctgacgtga aaaaagcgca ggtcatcggg atggacaaga 1232401 ttttatataa tcatgagctt tattgtacag tttgcgatta caacaatggg ggatgcgaaa 1232461 tacataatac ggtgaaggaa atgaaaatca atcaccaaag cattccgttt gatcacaagc 1232521 cataccataa ggatgaatcc catccgtttt atcggtatga tccagatcaa tgtatattgt 1232581 gcggacgctg tgttgaggca tgccaagacg ttcaggtaac tgaaacgctg accattgact 1232641 gggagcggaa acgcccgcgc gtcatttggg ataacgacgt gccgatcaat gagtcgtcat 1232701 gtgtgtcatg cggccattgt tcaacggtct gtccgtgcaa cgcgatgatg gaaaaaggaa 1232761 tggaagggga agccggatat ttaacaggca tcaataacga aacgctgcga ccgatgatcg 1232821 agatcacgaa aggcgtagag acaggctacg gctcgattct cgcgatttct gatatggaat 1232881 cggccatgcg tgatgaacga atcaaaaaaa cgaaaaccgt ctgcacgtat tgcggcgtcg 1232941 gctgcagctt tgatgtctgg acaaagggca gagacattct gaaagtagag ccgcaggagg 1233001 aagcgcctgc caacggcatt tctacttgtg tgaaaggcaa gttcggctgg gatttcgtta 1233061 acagcgaaga acgcctgaca aagccgctga tccgtgaagg cgatcatttc cgtgaagcag 1233121 agtgggagga ggcgttattg ctgatcgcca gcaagttcac tgaattaaaa gaggcgtttg 1233181 gcccggattc tctcgctttt attacatctt ctaaatgtac aaatgaagaa tcctatctta 1233241 tgcaaaagct ggccagaggg gtcattggca caaataatgt ggacaactgc tctcgctatt 1233301 gccaatctcc tgcgactgcc ggcctgttcc ggacagtcgg ctatggcggt gattcaggat 1233361 caattacaga tatcgcgcaa gcggaccttg ttttgattat cggttcgaac acgtctgagt 1233421 cgcatccagt cttatccact cggattaaac gggctcataa gctgagaggg cagaaagtga 1233481 tcgtcgcgga tatcagaaag cacgaaatgg cagagcgctc agatttattt gtccagccgc 1233541 gtgccggatc ggatatcgtc tggctgaatg cgatcgccaa atatttaata gaaaacggca 1233601 aggccgatga acgatttttg agagaaagag tgaacggacg ggatgaatat gtaaaaagcc 1233661 tcgcgccgta cacacttgaa tatgctgagg agaaaaccgg gattgatcaa gaaaccctta 1233721 tccaaatggc agagatgatc gggcaagctg acagtgtgtg cgcattgtgg gcgatgggcg 1233781 tgacacagca tattggagga agcgacacga gcacggcgat ctctaatctg ctgcttgtga 1233841 caggaaacta cggaaaaccg ggagcaggtt cttacccatt gcgcggccat aacaacgtgc 1233901 agggagcaag tgactttggg agtatgcctg acagactacc gggctatgaa aaagtgacgg 1233961 acgaacaagt ccgccaaaaa tacgagcgtg tgtggggtgt gccgctgccg aaggagccgg 1234021 gtatgaccaa ccacgaaatg attgaaaaaa tccattccgg acagttgaaa gcgatgtatg 1234081 taaaaggtga agaaatgggc cttgtcgact ccaatatcaa tcatgtacac gctgcatatg 1234141 aaaagcttga tttctttgtg gtgcaggaca ttttcctttc acgtacagcg gagtttgctg 1234201 atgtggttct tcctgcgagc ccgagccttg aaaaagaagg aacgtttaca aacacagaac 1234261 gccggattca gcgtttgtat caggtatttg aaccgctggg tgaatcaaag ccggattggc 1234321 agattattat ggaggttgcc aataagcttg gcgccggctg gctctatgag catcctgcag 1234381 acattatgga ggaagcagcc aagctgtcgc cgatttatgc cggtgtcacc tatgaacgtc 1234441 ttgagggcta taattccctg caatggcctg taaacgctga tggaaaggat tcgcctttac 1234501 tctttacaga gcgcttccct ttcccagacg gcaaggccat tctctaccct gtccagtgga 1234561 cagagcctaa ggaattcggt gaggaatatg atatccatgt caacaatggg cggctcttgg 1234621 agcacttcca cgaagggaac ctgacttaca aatcaaaagg gatttcggag aaaacaccgg 1234681 aagtgttctt agaaatttct cctgagcttg cggcagaacg agggattcag gacggaaccc 1234741 tcgtcagact cacatcgcct ttcggaaatg tcaaagtgaa gtgcctgatt actgatcgag 1234801 tcaaagggaa ggaagtatat ctgccaatga acgattcagg ggaagcggcg atcaacctgt 1234861 taacaggcag ccatgccgat aaggataccg atacgcctgc ttacaaagaa acatcggcca 1234921 agatggaaat tttgaagcac gacggaatca gcccgctgcc taagatcaac caccgcaacg 1234981 gcaatccgca gccgcaaatc ggtgtgcagg ttcataagaa atgggcgcgg aaggattata 1235041 ttttccctgg tgacgctgtg aaaaggggga tgggccataa tggctaaagc gattaaacga 1235101 atccaaaaaa tcgaggtaac agaagaggat cagcgaaagc gtgatttgcg ggaaattgaa 1235161 gatgctctaa ttgaccacaa agaagcgatt ctcgaaacat tgcatatgct gggccatatg 1235221 aacgagcgcg gggtcctgcc gttgctccgc ggcctttttg gtcaagggga taaagttctt 1235281 gatatcctgg tgaaaaaggc agatacagag gaaacagcca atacgctgaa aaatctgctt 1235341 cttctgtttg gaacactcgg catgctggac gtgaagcagc tggagcctct cattttgaaa 1235401 gtgaatgcgg gtgtggcaag cgctgtagag cagaaaaaca gtgaagaaaa gacaggttat 1235461 tttgatatta tccgctcgct aaaagacccg gaaatcaaca aatcaattac actgctcttt 1235521 tcctttttaa aaggaatggg acaagataca aaggagctgg aacgcacgac gcagcctccg 1235581 gaacaccaaa aacatcatca ggaaccccga gagaaaagag gaatgaataa gcgagattga 1235641 cctcccaccc gagcggcttc agccagctcg ggttttttga tgaaaaggtc taatggacta 1235701 gtaaaaaata ttcaaatact aggaagaagt aagattgtga tgaatgagat agaaataatc 1235761 gttactttct tacctgttaa gaaaagggaa aatctgatta taatagaaat cgattacttt 1235821 agatggggga acaatcatga aaaaagtctt attactatta tttgtcttga cgatcgggtt 1235881 agcgctttct gcgtgcagcc aatcgagcga tgcgtcagag aaggaaaaac cgaaagagaa 1235941 aaaatcgcaa gaagagcttg aaaaggaact tgataaggaa ttgaaaaaag gcggtgagcc 1236001 gaagaccaaa aaagatgatc aaatacataa aataggagaa acatttaaag caggacatac 1236061 gaattttaca gtgaataaag ttgatagagt gcaaaaaggt gaatatatga atgttggcgg 1236121 agctgtaaat gaggagacaa aaacaataaa agatgatgag gaacggctta ttatagaagt 1236181 tacgatggaa aatatagggg aagattcaat aagctacaat tttatcgggt ttgatttaag 1236241 agataagaat gatcaatcag tgcggcctgt tttttctata gaagagaagg gcagaatcct 1236301 tatgggagga acactagtat cggggaaaaa ggttacaggt gtactcagtt atgtcatccc 1236361 taaaggagaa cagaaacatt acacactggt atataatccg tttttagctg atacaaatag 1236421 cagtaataca gaagagagag taaaggacga tattgattac ttggtgaagt tagattagat 1236481 gctaatttac agttgcacgt ttttcatctg tggaaaacgt gcatttttta tagcgaaact 1236541 tgacttgaaa ggatgagtga taaaagtgca aaccaaatgg ctggaacggg cacagcggat 1236601 tcgggcgatc gcccaagcgg ggcttgcttt ttccaaggat gtgtacgaca gggagaggta 1236661 cgaagagcta atgaagctta gcgcggaaat gatggcggat tactcggaga aggacattga 1236721 agttatcact gatttatggc aaggcgagaa gggctatcca acaccgaaag cggatgttcg 1236781 cggcgctgta ttcagagaga atcagatttt gcttgtccgg gagaagcatg atgagctgtg 1236841 gtcgctgccg ggcggatttt gcgagattgg tttatcgccg gctgaaaacg ttgtcaagga 1236901 aatcaaagaa gagtcggggt acgatacaga gccgtctcga ttgctggccg tgctagacag 1236961 ccataaacac tctcatcccc ctcagcctta tcactattat aaaatcttca tcgcatgcag 1237021 catgacggac gggcaggggg aaacagggat cgagacgaat catgccgctt tttttccgga 1237081 agacagactc ccgccgcttt ctcctaaacg aaacacaccc tcacagctta gcatgctgtt 1237141 tgactttttg cgccatccgg acaagaaaac gatatttgac taaaaaagaa agagcctgtg 1237201 ggctctttct tttttataat gtaatgtgtt tttcgttggc gagtttcaga agggtcaaaa 1237261 tagaatcggc ttgtttatgg ccgagttttt gctttaattt gttttcttca actaatcggc 1237321 tgccataaat tttgacggag gctttgtcga cgacagtatg ccagttttcc tgtttttttc 1237381 cctcaacaag cggtttttca tgtctctcag aaaaagagaa cacaaagagt acgaatgcaa 1237441 gtgaaagtag gattccgaca acttgttttt tgtaatcagt ctgtgctgcc acgttgttct 1237501 ctccttcacc ttttaccttc tatttaatca tagaaccaaa ttattttaca taatgggaaa 1237561 gtcatttttg gagttagtgc atttggttga aaacagagac gttttttgag cggagcggtg 1237621 caattgaatc catattggat ttgcgtgctt atgcctaagg tcacgttgtg agccaaaaca 1237681 gcagtgcaga atagaaaaaa attgaaagat tatggtaaga tgaacgaaat tcgaggggga 1237741 atatatgatg cctgcatcga acatcgtgat cgcctgcctg ctgttatcaa tttaattatt 1237801 tgtggtagtc cctctctttt tcgaaagcgg gaggtgaagt ggaacattaa ttgctgaatt 1237861 ctttcaaggg gagtgaccgt acatgaatgt gttaaaccgc cggcaagcct tgcagcgagc 1237921 gctgctcaat gggaaaaaca aacaggatgc gtatcatccg tttccatggt atgaatcgat 1237981 gagaaaggat gcgcctgttt cctttgatga agaaaaccaa gtgtggagcg tttttcttta 1238041 tgatgatgtc aaaaaagttg ttggggataa agagttgttt tccagttgca tgccgcagca 1238101 gacaagctct attggaaatt ccatcattaa catggacccg ccgaagcata caaaaatccg 1238161 ttcagtcgtg aacaaagcct ttactccgcg cgtgatgaag caatgggaac cgagaattca 1238221 agaaatcaca gatgaactga ttcaaaaatt tcaggggcgc agtgagtttg accttgttca 1238281 cgatttttca tacccgcttc cggttattgt gatatctgag ctgctgggag tgccttcagc 1238341 gcatatggaa cagtttaaag catggtctga tcttctggtc agtacaccga aggataaaag 1238401 tgaagaagct gaaaaagcct ttttggaaga acgagataag tgtgaggaag aactggccgc 1238461 gttttttgcc ggcatcatag aagaaaagcg aaacaaaccg gaacaggata ttatttctat 1238521 tttagtggaa gcggaagaaa caggcgagaa gctgtccggt gaagagctga ttccgttttg 1238581 cacgctgctg ctggtggccg gaaatgaaac cactacaaac ctgatttcaa atgcgatgta 1238641 cagcatatta gaaacgccag gcgtttacga ggaactgcgc agccatcctg aactgatgcc 1238701 tcaggcagtg gaggaagcct tgcgtttcag agcgccggcc ccggttttga ggcgcattgc 1238761 caagcgggat acggagatcg gggggcacct gattaaagaa ggtgatatgg ttttggcgtt 1238821 tgtggcatcg gcaaatcgtg atgaagcaaa gtttgacaga ccgcacatgt ttgatatccg 1238881 ccgccatccc aatccgcata ttgcgtttgg ccacggcatc catttttgcc ttggggcccc 1238941 gcttgcccgt cttgaagcaa atatcgcgtt aacgtctttg atttctgctt ttcctcatat 1239001 ggagtgcgtc agtatcactc cgattgaaaa cagtgtgata tacggattaa agagcttccg 1239061 tgtgaaaatg taatagataa ggagactgga gattcatgaa aaagtaccat atttcgatga 1239121 tcaatatccc ggcgtacgga catgtcaatc ctacgcttgc tttagtagag aagctttgtg 1239181 agaaagggca ccgtgtcacg tacgcgacga ctgaggagtt tgcgcccgct gttcagcaag 1239241 ccggtggaga agcattgatc tatcatacat ccttgaatat tgatcctaag caaatcaggg 1239301 agatgatgga aaagaatgac gcgcccctca gccttttgaa agaatcactc agcattctgc 1239361 cgcagcttga ggagttatat aaggatgatc agcctgatct gatcatctat gactttgttg 1239421 cgctggctgg taaattgttt gctgaaaagc ttaatgttcc ggtcattaag ctctgttcgt 1239481 catatgccca aaatgaatcc tttcagttag gaaatgaaga catgctgaaa aaaataagag 1239541 aagcagaggc tgaatttaaa gcctacttgg agcaagagaa gttgccggct gtttcatttg 1239601 aacagttagc tgtgccggaa gcattaaata ttgtctttat gccgaagtct tttcagattc 1239661 agcatgagac gttcgatgac cgtttctgtt ttgtcggccc ctctctcgga gaacggaagg 1239721 aaaaagaaag cctgttgatt gacaaggatg atcgcccgct tatgctgatt tctttgggta 1239781 cggcgtttaa cgcatggccg gaattttaca agatgtgcat caaggcattt cgggattctt 1239841 catggcaagt gatcatgtcg gttgggaaaa cgattgatcc agaaagcttg gaggatattc 1239901 ctgctaactt taccattcgc caaagtgtgc cgcagcttga ggtgttagag aaagctgatt 1239961 tgttcatctc tcatggcggg atgaacagta cgatggaagc gatgaacgca ggtgtgccgc 1240021 ttgtcgtcat tccgcaaatg tatgagcagg agctcactgc aaatcgggtt gatgaattag 1240081 gccttggcgt ttatttgccg aaagaggaag tgactgtttc cagcctgcag gaagcggttc 1240141 aggctgtatc cagtgatcaa gagctgctca gccgcgtcaa gaatatgcaa aaggatgtaa 1240201 aagaagctgg cggagcggag cgtgcggcag ctgagattga agcgtttatg aaaaaatccg 1240261 ctgtcccgca gtaaaaacat aaaaaccgaa atcaatttga tttcggtttt ctgtttaaat 1240321 attttttttc atcccgcatc tccggcattc tctaagaaat tttccgcctt ttacagagct 1240381 tttgaacagt gtgtaatcac agttgtcgca gcgcccgctg cgggcatccg gatattcatt 1240441 gaattcgtaa acaatcgatg tatcgtagcc ttttgtttca tattcttctt ttttggtttc 1240501 catgtcgatc ctccgttaca agacgtgtct gctgtttatc ttacagcaag cttccggcgt 1240561 attcaatgga ttttaggagg ttgggtttat cttgatttct cccttggttt gcgccaaaat 1240621 agctttatta agcttatata cataaaaagc ctatgcaaag aggagaggaa acgggtatgg 1240681 gaaaagggtt acttggaaaa cgcgtggcaa tcggtggctc acgaaaaacg gaagaaatta 1240741 gtacaatcat tgaaaaacag ggcggaatac ctgtcatccg gcctctccaa ggtacagttt 1240801 acttagcaga gaagcaggtg gagccggatt tgcggacgtt tgcggaagaa aaagctgact 1240861 gggtcatttt cacgacaggc atcgggttgg agactcttgt cgatatggca gagaaaattg 1240921 gactgaaaga tgagtttctg caggccattc gccaagcgaa agcggcatgc cggggataca 1240981 aaacgctgtc tgcgctgaaa aagcttggaa tcacaccgga agcttcggat gaagacggga 1241041 caacaagagg cttaatccgt tccttggagc ctcacgactt ttcaggaaaa acagtcatgg 1241101 tgcagcttca tggcgaaaaa gcgccggctc tcatggcatt tcttgaagaa aaaggcgcgt 1241161 ctgtcctgcc gattctgcct tatcagcaca tcccgccgga ggaggaaacg gtggagcggt 1241221 tatgccgaga gctgatgaac gatgaggtcg atgccgtttg ttttacaacg gccattcagg 1241281 ttcgttccct gtttgatttt gccaaggggc gaggttatat caatgaagtg aagaaggtat 1241341 tcgaagaacg cgccatcgca gctgctgtcg gaaaagtgac tgctgaagca ctgcgggaag 1241401 agggcattac gagactgctt gcgccagaga ttgagcggat gggtgcgatg attgttgagc 1241461 tggccaagta ttatgaagaa aaggaataac aagtacaaaa agccgctttt ccctcggaaa 1241521 gcggcttttg tctgtcattc attttgcttc agctgctgat gaacggtgaa taatgatggg 1241581 tatgtcagca cgcttaagat tacacaagtc agcgcggctg aggccatcgt tgtaaacacg 1241641 attaagagtt gaaagcgtac tgcctgaatc gggtccgcgc cggctagaat ctggccagtc 1241701 atcatgccgg gaagctggac aagacccagt gttttctggc tttcgagcgt cgggatcata 1241761 ctcattttca tcgctgaggt aagaatgcgc tgtatggatt gcttcggtgt gccgccaagt 1241821 gacaatatta attgaatttc ttctttgcga acgccgactt ctgagttaag ccggtttaga 1241881 aacaaacttg agagcaccat cgaatttccg atgaccatcc cgctgatcgg aatgacatat 1241941 cgtgccgtaa gcggaatgat atgaagagac agcagaattc cctgcgtcac aatttctacg 1242001 attgctaacg cggcaaacac cctccaaaac gaaccgatag tatttttctt tcgcttgatg 1242061 acattttgcg ccgccaccgc gagcattaac agcaccatca gcaggataaa aacagggtgg 1242121 tctccgcgaa aaatcagcga caaaacataa ccgatgataa gcagctgcac cgcggcccgg 1242181 atggtggcga tgatcatgtc tttttctaca ccggctttaa aggattttga taaaaacaag 1242241 gcgatcaaaa caaagatcat cgttaaagag agagaaaggt aatccattac cgagtgcctc 1242301 ccttcaaaaa ttctttcgct gcttcatgct gcggagcgga gaaaaatgtg tcggtttcag 1242361 cgatttcaag cagccggcca tctgccataa accaaatggt atcggctatt cgttttgcct 1242421 gctccatatt atgagtgacc cacatgactg tccatttttt ctcttgatgc tgacgtttga 1242481 tcagttcttc aatctcaaga gcagagaccg ggtccaaggc cgatgtgatt tcgtccaaca 1242541 atagaatgga ggaaggattt gagagcgttc tggccagtga cagtctttgc cgctgcccgc 1242601 ccgataagtc tctggcgctt ctgtctaaca actctggcgg cagccctgca agcgaagcca 1242661 gcttttcagg agagtacagc tgggattgat gcagcctttg tacaagactt aaattgtcac 1242721 gcactgtccc gtcgagcacg ggagccgatt gaaacgcgag ggctgccgtt cgcctcagct 1242781 cattgacatt ccattctctg acttcctttc cgtatatgtt gacttcgccg ctgtcaggcg 1242841 ttctcattaa attacacata gaaaggaggg tgcttttgcc tgagccggaa gggcctaaaa 1242901 cggctacgat tgcaccctgt tgaatgtctc cggtgacatc ctgcagcaca tcataggttt 1242961 gtccatcttg tttatagctt tttctgactg atctgaagga gatggctggt atgttttgtg 1243021 tttgatcgtt tgcttccatt acaataatca cctttcaata taagtaggct gacattatat 1243081 ttaactataa cgtgaaacag attccttttg gtagcacaaa taaaggagaa caggctttca 1243141 cccattctcc tgcagatgct acgcagtcag atttgactgt gctttctttt tcggttttct 1243201 cggctgtgaa gcgaaggtat gtaacatcat ccccgctatt ataatgaaca aaccggcaaa 1243261 tgataataga gatgggaaaa cgcctgacag cagaacaatt tcaccaagca gcgcgaaaat 1243321 cacttcaccg gattgagtgg cttcaacagc tgcgagtttt tgcggattgt ctcttaccat 1243381 atcagtggcc cagaaaaata aaaccgtcgc aatgatgcct gagctgacgg caacgataaa 1243441 ggattgaacg gtttgacttg ctgttggaag gccatctgac caccagccgt aagctgctaa 1243501 tataagccag aatggaaggc ttgccaatgt cattccaagc acgcgctgaa atgtatcaag 1243561 ccggcctccg tattcttcga gcattcttcg gtttcctaac ggataggcaa aagccgcaat 1243621 gacaaccggc agcacactga aaagcagcat cctcccagaa agcgattctg catgctgaag 1243681 ctgaatcaga gccgctccaa tcaggatgat cacagaagtg ccaagtgaaa ccaggggaat 1243741 cttttggcga atgagctgcg gaccgcccgg catatcttgt ttgacataaa acaaaggaga 1243801 taagagcacc ccggctacaa ttgtaatttg ccaggttcca gctatgagcc accccggacc 1243861 gtatgcagcc gcaaatgtaa tcggtgcgta aaaaagcacg aaaccgacga agctccattt 1243921 gatccaataa aacggctttt tcctcatttc tagtaagaga ggcgtgaatg tccctctcat 1243981 gatgacaatc aaacataaaa atggcaccat aaaaataaag cgcagcgaag agctccaaag 1244041 ccagctgcct cctgataact ccatcgctct gtttaatata aaggtaacgg cgaaaaagag 1244101 tgaagccaat attccgataa cgatagcttt catgatatcc ctcattctgg cattattttt 1244161 ttatactata ctattcggta tcatgcagat caatggaatc atgagaaaaa catcatgttt 1244221 ggcgaaccgc tatatgtgga agacaaaaaa gggaggtgaa attgatggaa agagagacac 1244281 agacatactt ctttccggat gacggcagga ttccgaatca ccctgatttt ccgctcgtgg 1244341 tgtatcaaaa cgcgcttaag gacaccggac tggcagagcg gatcgtcacc cggcatggct 1244401 ggtcaaacag ctggtcaggg agtgtttttc cataccatca ttatcacagc aatacgcatg 1244461 aagtcctgat tgcccttagg agagaggctg tgattcagtt tgggggagaa aaaggggctg 1244521 ccatcccttt caaatcaggc gacgcagtcg tgattccagc cggagtcgga cataaaaagc 1244581 tcagctcaag ccccgatttt actgtccttg gcgcctatcc cggtggcgtt cagtacgata 1244641 tgaagacggg gaagccgaat gagcgggagg aagcggtcaa acagattaag caggcggcgt 1244701 tgccggcgaa tgatccgatc acaggaaaaa gagagcctct attggaaata tgggtaaagt 1244761 gaaggggaga aattgctgga ttgtcaataa ctagtgccgc agaaacgata tgacatgagc 1244821 tccatataaa ttaatttcat aatcgaagca attcacgttc aaattttgtt caaaaagtgt 1244881 tatcatatag aaggtaatcg aattggagtt ttttgtgttt gctattttca gagagagtaa 1244941 aggattttga cttattcaat tgtttatttt tagataaaaa taatactgaa tatggcaaga 1245001 tgaaaaactg ggtagtaaac atttattttt gtaaatgatt gtgcatgaat tcacaatcct 1245061 tattcttatg ccttaaaagc gtgagacagg gagaggcact accctttcca aaaaaatcag 1245121 caaactgctt atagtaaagg agaattggat atgccagaaa caatcgatca aacaaatgcg 1245181 tctgtcagcc aaagccagca agatcttatt gatcagctat taaagccaga agttcaagaa 1245241 tcattgactg ttttagttga ccagcttccg aagctgactg agttagtgaa tattttaacg 1245301 aagtcttatg atttcgctca gtctgtagcg actgacgaag tgttaaagag cgacacagtc 1245361 ggtgcgatca ctgaaattct cgagcctgta aaagaaacag cgaaagaagt agctgcgact 1245421 gcgatcgaag caaaagaccg cgcggaagca agcaacgaaa caattggact tttcggcctt 1245481 cttcgcatgc tgaaagatcc tcaagctcaa aagctgttcc gttttgctaa cagctacctt 1245541 gaagtcatga acgaacgcga aaaccaaaaa taatctcaga ttcaaattga tataaaggac 1245601 ggaggatata cgatgtcaaa acatattgtc attctaggcg ctggttatgg cggagttctt 1245661 tctgctctaa cagttcgcaa acattacaca aaagaacaag cacgcgtgac agtggtaaac 1245721 aaatacccaa ctcaccaaat cattacggaa ttacaccgcc ttgctgcagg caacgtgtct 1245781 gaaaaagcgg ttgcaatgcc attagaaaaa cttttcaaag gcaaagacat tgatcttaaa 1245841 attgcggaag taagctcttt ctctgttgat aaaaaagaag ttgcgcttgc tgacggttct 1245901 acattaactt acgatgcgct tgttgtaggt cttggttctg taacggctta cttcggcatc 1245961 ccaggtcttg aagaaaacag catggtattg aaatctgctg ccgatgcgaa caaagtcttc 1246021 caacatgttg aagatcgtgt gcgcgagtac tctaaaacga aaaacgaagc agatgcaaca 1246081 atccttatcg gcggaggcgg cttaacaggt gttgagcttg ttggtgagct tgctgacatc 1246141 atgccgaacc ttgcgaaaaa atacggcgta gaccataaag aaatcaaatt gaaacttgtt 1246201 gaagcaggtc cgaagatcct tcctgttctt ccggatgatc ttatcgagcg tgcgactgca 1246261 agccttgaaa aacgcggcgt tgagttctta acaggtcttc ctgttacaaa tgtagaagga 1246321 aacgtaatcg atctgaaaga cggatctaaa gttgttgcca acacatttgt ttggactggc 1246381 ggcgtacaag gtaacccatt agtcggtgaa tcaggcctag aagtgaaccg cggacgcgcg 1246441 actgtaaatg acttcctgca atctacatct catgaagatg tattcgttgc tggagacagc 1246501 gcagtttact tcggtccaga cggccgtcca tacccgccaa ctgcacaaat cgcatggcaa 1246561 atgggtgagc tgatcggtta caacctattc gcttacctag aaggcaaaac gcttgaaaca 1246621 ttcaagccag taaactctgg tacacttgca agccttggac gcaaagacgc ggttgccatc 1246681 attggtgcta attctacacc gcttaaaggt cttcctgctt ccttgatgaa agaagcaagt 1246741 aatgtacgat atttgacaca tattaaagga cttttcagcc tggcttacta atccttttaa 1246801 tgaatctggc attgccaaaa gcattccttt ccgagtgctt tctggcaatg tcttttttta 1246861 tgtttatgac agcgttaaca tttcattttc aaaaaagaga ttgatcccaa aggaatataa 1246921 aggtaaaata aaaacaaatc aaaatgttaa cgttaacatt ttgaaataga atgaaagacg 1246981 gtgaggacat ggaacccttc atgggcaaaa actttttatt gaaaaatgaa accgctgtca 1247041 gcctctatca caattatgcg aaagacatgc caattattga ttaccactgc cacttaagtc 1247101 cgaaagaaat ctatgaaaat aagacatttc aaaacatcac ggaagcctgg ctgtatggtg 1247161 accattataa atggcgcatc atgagagcca atggaattga ggagacatac attaccggag 1247221 atgcgcctga tgaggagaaa tttatggctt gggcgaaaac cgtgccgatg gcgattggca 1247281 acccgctcta caactggact cacttagaat tgcagcgttt ttttggcatt tacgagattt 1247341 taaacgagaa gtccgggtcg gctatatgga aacagacaaa taaactgctc aaaggggaag 1247401 gcttcggggc aagggattta atcgtgaaat caaatgtaaa ggtcgtgtgc accacagatg 1247461 accctgttga ttctcttgaa taccatttat tgttaaaaga agacaaagac tttcctgtca 1247521 gtgtgctgcc tggatttcgg ccggataaag gacttgagat caatcgtgaa ggctttcctg 1247581 agtgggtgca ggcgcttgaa gatgccgctg ccatatcgat tacaacctat gatgagtttt 1247641 taaaggcgtt ggaaaaacga gtgcgattct tccactcagc cggcggcaga gtttctgatc 1247701 acgcgataga tacaatggta tttgccgaaa caacaaaaga agaagctgga cggatttttt 1247761 ctgacagatt acaaggaaca gaggtttctt gtgaagatga gaagaaattt aagacatata 1247821 cgcttcagtt tctttgcggt ttgtatgcgg agctcgattg ggcgatgcag tttcatatca 1247881 acgctttaag aaacacgaat acaaaaatga tgaaaaggct cggacctgat acagggtatg 1247941 attcaatgaa cgatgaagaa attgctaagc ctttatacaa gctgctgaac tcagttgaga 1248001 tgaagaacca gctgccgaaa acgattttat attcactgaa tccaaatgat aactatgtca 1248061 tcgccagcat gatcaacagt tttcaggacg gtattacccc gggaaaaata caattcggca 1248121 cagcctggtg gtttaacgat actaaagacg gaatgctcga ccaaatgaaa gcgttatcaa 1248181 atgttggcct tttcagccgt tttatcggca tgctcaccga ttccagaagc tttctttcgt 1248241 atacgcgcca cgaatatttc aggcggatcg tctgcaattt gattggagaa tgggtggaaa 1248301 acggcgaagt gccgcgcgat atggagcttc tgggaagcat cgttcagggg atttgctatg 1248361 acaatgcgaa acactacttt caatttcaag aagagaaagc aaacgtgtaa caaagtgtcc 1248421 gctcagtatc gctgagcgga tcactatccg aaaattctta agacacagag gtggaacatg 1248481 cgaactgaac tggcaaataa ggttgtgtcg gtcgaaacgg aaaaaaggct ttcattgaaa 1248541 gagaaaatgt cctatggctt tggtgatttt ggcaacggtt ttatgtttga tctcggccag 1248601 atttatttat tgaagtattt cactgatgta gcgggaatcc ccgctgcgat ggccggcggc 1248661 atttttttag tcagtaagct gtttgcagcg ataacagatc caattgtcgg ctcatcaatc 1248721 gattatcgca aaaacatcgg caaacggggg aaattcaggc cttatctatt aatcggcagc 1248781 atcgtgcttg cggtgcttac tgttcttatt tttctgtctc ccaatgtatc aacgaccgga 1248841 aaactgatat atgcatatgc atcctatatg atttggggca tcggctattc gtttgtgaat 1248901 attccgtacg gctcattagg ggcagcgatg actcaaaatt ctgaggaccg gacctccatt 1248961 tcgacgttcc gccaaatcgg atcacttggc gccttgttta tcacaagtgt ggccgtgatg 1249021 ccgctgctcg tcaagtttga taatccgaag gtcggctacc cggtggtcat gggcttgttc 1249081 gccgcgctcg gtgtgttttg gttttatatt tgctaccgca actgcaaaga gcgcattatc 1249141 atatcggaag cacccaaaga aaaattaaca ctctcatctg tcgtcaaaac atttattaca 1249201 aataaaccgc tgttaaccct tgtcctgatg acgatttttt caatttccgc atacaacatt 1249261 aaatccgcca tgctcgtcta tttcgcacaa tataacttgg gcaatgttga attaatggct 1249321 tatatgaact tcatcattat tggttcttcc tttttgggcg tcgtattcct tccaaagctc 1249381 gtcaagatgt ttggaaagaa acgaacggca atgatcggct ttggcatcag tgtggccgcg 1249441 gatctgatca actttatgct tccatctaac gtttatgtgt ttacaattct cgccagtatc 1249501 gcctttatcg gaatcagtat cccaaatggc atcacgtggg ctcttgtctc cgatattatc 1249561 gactatggcg aatggaaatc cggtgaacgg aaggaagcaa cgacatattc acttttcaat 1249621 ttctcaagaa agcttgctca atctttgtct ggctttctct cggggatcgg tttggggatt 1249681 atcggctatg tgccgaatgc agtccagaca gcacaggcgc tgattggcat caaagcgctg 1249741 cttcttctgt atccggccat tgctttggca ttagcgatgt tcattatcgg ctttctttat 1249801 aaactcacag accagcagca tgctcagatc gttcaggatc ttcatcaaaa gagctgacaa 1249861 tataatataa agaatattta aaataatttg taaataaaat gtgtttgtag gggtttcgct 1249921 tggagagtgc ccaaaaaact gaaaaggaag gaggcacttg cttgaaaacg ataacaattg 1249981 cagctgaaga agcaaaggaa ctcgtttggc aaaagctgga cggtgccggt ttgaatgaac 1250041 gagatgctga aaaagtggca gatgttctcg tgcacgctga tttgcgcaat gtacattcgc 1250101 atggcgtgct gcacacagaa cactatgtga acaggctttt agcgggaggg atcaatcctg 1250161 gggcacagcc tgtttttaaa gagacggggc ctgtgaccgg ggtgcttgac ggagacgatg 1250221 gtttcggtca tgtgaattgc gacatggcga tggaccatgc aattgacatg gcgaagaaaa 1250281 aaggagtcgg catggtcacg gccgtaaaca gcagccattg cggagcgcta agctattttg 1250341 tgcaaaaagc ggctgacgaa aagctgatcg gaatggcaat gacgcataca gacagtatcg 1250401 ttgtcccatt tggggggagg actcctattt tagggacaaa tccgattgct tacggagttc 1250461 cggctaagca taaaaaaccg tttatcctag atatggcgac atccaaagtg gcttttggga 1250521 agattctgca ggcccgtgaa gagggcaaag aaattcctga aggatgggga gtcgatgaaa 1250581 acggagaagc agtaactgat cctgacaagg tcgtctcact ttcaacattc gggggcccga 1250641 aaggctatgg actatcgatt gtagtggatg tgttttccgg attgctggcg ggcgcggctt 1250701 ttggccctca tattgccaaa atgtacaacg gccttgatca aaaaagaaag ctggggcatt 1250761 acgtttgcgc gatcaatcca tcctttttta ctgactggga tacgttttta gagcagatgg 1250821 atgccatgat tgatgaactg cagcaatcac cgccggctgt tggattcgaa agagtgtatg 1250881 tgcccggcga gatcgagcag ctgcatgaag aaagaaataa gaaaaacgga atttctatcg 1250941 cccggagcgt gtatgaattc ttaaaaagca ggtgagtaaa atgaaagcgg ttcaagtgcg 1251001 aaaagcgtat gatctggtga cagcggaggt gaagaagcca gttctttcaa aggatgatga 1251061 agtgctcgtg aaagtcaagc gagtcggcat ttgcggttca gacatgcaca tttatcatgg 1251121 aacgaatccg ctcgctaccc tcccgagagt catcggacac gaggtaacgg gacaagtgga 1251181 ggcagttggt gcgaatgtac agagcctaaa acccggtgat catgtggtga ttgagccgat 1251241 ttcttattgc ggatcgtgct atgcctgccg caaagggcgg ccgaatgttt gcgccaagct 1251301 ttctgtattt ggcgtacatg aggacggagg catgcgggaa tatattgtgc ttccggaaag 1251361 acagcttcac gcggtctcaa aggacttgcc ttgggaggaa gcagtcatgg ccgagcctta 1251421 tacgataggc gcccaggcag tgtggagagg ccaggtggaa aaaggtgata ccgtcctgat 1251481 ccagggagcg gggcccatcg ggatctgtgt gttaaaaatg gcaaaactgg cgggcgctgc 1251541 tgtcatgatg actgacttga acaacgagcg gctggcattt gcgaaagaaa acggcgccga 1251601 tgctgttgta aatgtccaag cagaacatgt tgccgagcgg gtccttgaat ggactgggaa 1251661 tgaaggagca aacgtggtca ttgatgctgt ttgcctgccg gagacttttg cactttcaat 1251721 tgaggctgtg tcaccggcgg gacatgtggt tgtgcttgga tttgatgaaa gagcggctca 1251781 gatttctcag ctgccaatta caaaaaaaga agtcacgata accggatccc gattgcagac 1251841 caatcagttt ccaaaagtgg tagagctttt gaatggaggc cggttaatgc ataacgggct 1251901 ggtgacccat acattttcag ttgatgacgt tcatcatgca tttcagttta ttaaggagca 1251961 tccagatcag gtgcggaaag ccgtcatcac gtttgattaa atgactgaat ccggaggtgc 1252021 gagcatgaat atgacattcc gatggtatgg acgaggcaac gatacagtca cacttgaata 1252081 cgtgaagcaa attcccggtg tcaaaggcat cgtttgggct ctccatcaaa agcccgtcgg 1252141 cgacgtgtgg gaaaaagaag aaatcagagc cgaaactgaa tatattcaat cctatggttt 1252201 tcatgctgaa gttgtagaaa gcgtgaatgt tcacgaagcg attaaacttg ggaacgaaga 1252261 acgcggccgg tatattgaaa actacaagca aacgatccgc aaccttgccg gatttggcgt 1252321 gaaagtgatc tgctataatt ttatgccggt ttttgattgg acacgcacgg acatgttccg 1252381 gccgctagaa gatggatcga ccgctctgtt ttttgaaaag gccaaggtgg aaagccttga 1252441 tcctcaagag ctgattcgga cggtggagga agcatccgac atgacactgc cggggtggga 1252501 gcccgaaaaa ttggctcgga tcaaagagct ttttgctgcc tacagaacgg tcgatgaaga 1252561 aaagctatgg gacaatttat cattcttttt gcaggaaatt cttcctgttg ctgaggccta 1252621 tggtgttcaa atggccattc atccggatga cccgccgtgg ccgattttcg gactgccgcg 1252681 cattatcaca ggagaggcaa gctataagaa actgcgggcg atatcagatt caccgtctaa 1252741 ttgtatcacc ctttgtacag gttcaatggg agccaatccc gctaacgaca tggtggagat 1252801 cgctaaaacg tatgccggca tcgctccatt ttcacatatt cgcaatgtga aaatttatga 1252861 gaatggcgat tttattgaaa catctcattt aacaaaggat ggttcgatca acattcaagg 1252921 cgtgatggaa gaactgcata agcaggatta cgaaggatat gtcagaccgg atcatgggcg 1252981 ccatctttgg ggcgagcaat gccgcccggg atatggctta tacgatcggg cacttggcat 1253041 catgtatttg aacgggctgt gggacgctta tgaagcaatg gcaaaaaaag aggtgggcat 1253101 atgatcccgc tgcatgagaa cctggctggt aaaacggctg tcatcactgg cggcagcggc 1253161 gtgctttgct ctgcgatggc ccgggagcta gcccgtcatg gcatgaaggt ggcgattttg 1253221 aatcggacgg ctgaaaaagg ccaagcggtc gtgaaggaga taacggcggc tggcggcaca 1253281 gcgtgcgctg ttgctgcgga tgtgctggac aggatgtcac tggagcgggc aaaggaagac 1253341 atccttggcc aatttggcgc tgttgatctg ttaattaacg gggctggcgg caatcatcct 1253401 gacgcgataa ccgatgtgga gacatatgaa gaagcgggag aaggccaatc cttttttgat 1253461 atggatgaga ggggctttct aactgtattc tccaccaact tcaccggtgc gtttctggcc 1253521 tcgcaagtgt ttggtaaaga actgctgaag gcggattcac ccgcgatcat caacctttct 1253581 tccatgagtg cttattcacc tatgacgaag gttccggcat acagtgctgc gaaagcatcc 1253641 atcaataatt ttacgatgtg gatggctgtt cattttgccg aaaccgggct gcgggtcaat 1253701 gcgattgccc caggcttctt tctgacaaaa caaaatcatg atctgctgat caaccaagac 1253761 ggaacgttca ccagccgatc tcacaaaatt attgcgggaa caccgatgaa gcgcttcgga 1253821 aaaccggagg atttgctcgg tacgctcctt tggctggcgg atgaatccta ttccggtttt 1253881 gtcactggga tcaccgttcc tgtcgatgga ggatttatgg cttattcagg tgtgtaacga 1253941 aagcggtgca acagaaactg aaccaacata ggggtgaggt tgagatgttt tcaaaagata 1254001 agcttcccgt tatccttttt ttgttcctgg caggggtgat taattacctg gatcgctcgg 1254061 cgctttccat tgcagctcct tttattcagg atgatctcac attgtctgcc acacaaatgg 1254121 gcttgatttt cagcagtttt tcgataggtt atgccatttt taattttctt gggggcgtgg 1254181 catccgaccg ctatggggca aagctgacct tgtttgtcgc gatggttgtt tggtcgctgt 1254241 ttagcggagc agtcgccctc gcttttggct ttgtcagcct gctgattata cgcattctct 1254301 tcggaatggg agaaggcccg ctttcggcga ccatcaacaa gatggtgaac aactggttcc 1254361 cgccgaccca gcgggcgtcc gttatcggtg taaccaacag cggcacgccc ctcgggggag 1254421 ccatttccgg cccgatagtc ggcatgatcg cagtggcgtt cagctggaag gtatccttcg 1254481 ttctcattat gattattgga ttgatatggg cagtgctctg gttcaagttt gtcaaagaaa 1254541 agccgcaaga gacgatcaag gaagcaccgg caataaaagc agaaacgtct cccggagaaa 1254601 aaattccgct caccttttac ctgaagcaaa aaacagtcct gttcacggcg ttcgcttttt 1254661 tcgcttacaa ctacatcctc ttcttctttt tgacatggtt tccgagctat cttgtcgacg 1254721 agcggggatt aagtgttgaa tcgatgagtg tcatcacggt cataccgtgg attttaggat 1254781 ttatcgggct ggctgcgggg ggatttgttt ctgactatgt gtacaaaaaa acggcccgaa 1254841 aaggtgtgct gttctcgcgc aaggttgtgc ttgtcacgtg tttgttttca tcagctgtcc 1254901 tgattggttt tgccgggctt gtggcaacga ctgcgggggc tgtcactctt gtcgctctgt 1254961 cagtgttctt tctttatttg accggtgcta tctattgggc tgtcattcaa gatgtggttg 1255021 atcaaaacaa tgtcggttct gttggcggct tcatgcattt cctcgccaac acggcaggaa 1255081 ttatcggccc ggctttaacc ggatttattg ttgaccaaac aggcacgttt tctggagcat 1255141 ttttgcttgc cggtgggctg gctgtcttcg cttcacttgc tgtgattcgt tttgtccgtc 1255201 caatcattgg taagccagcg ggaacagaag ctgagaatcc tgtgtcttat taatctggaa 1255261 atatagtggg agaggcggta tgtttgatga tacaatatac agtaaataat cgcagccggt 1255321 atgataagga agggaattag atggtaacca taaaagatat cgcaaaactc gcaaacgtat 1255381 cccacactac tgtttccaga gcactcaaca acagccctta catcaaagaa catacgaaga 1255441 aaaaaatatt agagctagca gagcagctca actatacacc aaatgtaaat gcgaaaagtc 1255501 tggcgatgca aaagtcgcat acgatcgggc tattctttac aagcattaca aacggaacct 1255561 cacacagctt ctttgcagac actatcaaag gcgtcaatca agccataagt gaggattaca 1255621 atctgtatgt gcgcggcatt gatgatctga aaaactatga ctccgttaca ccgatgagat 1255681 atgacggcat cattttaatg agccaaagtg acattgataa ttcttttatt taccatattc 1255741 gcgaaaaaaa cattccgctt gtcgtgctga atcgtgatat tgatgatcgt accatcacga 1255801 atattttgtc caatgacaag gaaggctctc aagaagctgt agaatacttc attcagtccg 1255861 gacatcaaga catcgccatc atcgagggga tcgaaggctt taaatcctcc cagcagcgaa 1255921 aggaagggta cttatccgca ctgattcaac atcatattcc gatcaagcat gaatacagtg 1255981 tcaaaggaca gtacgatatg gaaagcggct ttcaagcgat ggagcggctg ctggcactgc 1256041 cgaatcctcc aaccgctgtt ttttgttcga atgatgacat ggcaatcgga gcgatgaatg 1256101 cgatattcgc aaagggcctg cgcgttcctg atgatatttc ggtgatcggg tttgatgata 1256161 ttgggttttc acagtacatc acgccaaggc tttcaacagt aaagcgccca gtggagaaaa 1256221 taagcgtgct cggtgcgcaa aaactcttgt cgctgatcag cgagcccgaa acaaaagcag 1256281 aaaaaatctt ggaaaacaca gaatttatgg tgcgtgattc agtcagacga ttgacgacgt 1256341 gatgtcccgt ttttcagcgg gcattcttta tacagaaaaa tgttaacgtg tgcataaagt 1256401 gagagggagg caataagggt gcagaagctg aataaaaatg tgtacgatca ctatactcag 1256461 tatccagaaa aaattctcca attcggagaa ggaaactttc ttcggggatt tatcgattgg 1256521 cagattgatc aattgaatca acacactgat tttaatggga gcgtggcagt tgtccagcca 1256581 agaggctcag aaaaaatcaa acgattaaat gagcaagatg gattatatac acttttttta 1256641 caaggaatga aagacggaga agcggtaaac gagcatatga ttatcaactc aatcagccgg 1256701 ggaattgacc tgttttctga ttatgaagca tacaaagaat tggcatcaag cgaaaggctt 1256761 cggtttatta tctccaacac cactgaggct gggattgtat gtgatgaaaa agatcgttta 1256821 gaggataggc cgcaaaaaac attccctggg aaattaactg catttcttta ctttcgctat 1256881 caggctttta aaggagatca gacaaaaggg tgtgtcctga tcccatgtga actgatcgag 1256941 aataacggtg aaaagctgag ggaaacggtt cttcattatg cacatctgtg gaagctggag 1257001 gaaggattta cacagtggat tcatgaggcc aatacatttt gtaatagttt agtagaccgg 1257061 attgttccgg gttttcccgt cgacagcatt gatgagatca cggcagatct tggctatcag 1257121 gatgatttga tagttgtggg agagcaatat tatttgtggg ttatcgaggg gcctgattgg 1257181 attggaaaag aacttccctt tgcggctgca gggctgcata caaagatcgt cagcgacctc 1257241 accccatacc ggactaaaaa agtaagaatt ttaaatggcg ctcatacagc aatgacgcca 1257301 gtggctttat tatacggctt gaagactgtt agggatgcag tcgagcatcc ggaagtgggg 1257361 cgatttataa gagagctgat tgatgacgaa attcttcctg ttttaaaaat ggaaggtctt 1257421 tctcagtatg ctgacgatgt gctgaaccgt tttaaaaacc cgtatattaa gcattacctg 1257481 gaaagcattg cattgaacgc catttccaaa ttcaaaacga gaaacctgcc gactcttaag 1257541 gaatatgctg aacaaaaggg acagcttcct gaacgcttgg tgttttcttt cagcgctctt 1257601 ctgtattttt atcatgataa cgagacattg caggatgatc cggcagttct tcaatttttc 1257661 aaagaggttt ggtgtcagga ggatggcgac atgcttcgga ttgcatcaag agtgttaggc 1257721 gaacagcggc tgtggggggc agatctcaat gagataccga agctgactga tagagtcgct 1257781 gtttacttga atcatattca tgagctgggc atgcagaggg ctcttgaaca atactgcata 1257841 caagggggag aggtacgttg aagtcgttta taaagattca taagcaagat aatgtccttc 1257901 ttgctctgcg ggatattcaa aagggagaga ggctgcatgc ttacggcgtg tcgattgaag 1257961 taaaggatga tataaaaaga ggccataaga ttgcattgca gtctatcaaa gaaaacgaca 1258021 gcatcgtcaa gtacgggttt ccaatcggtc atgcatcaca agatatctcg atcggagagc 1258081 atattcatgt ccataatacg aaaacaaacc tgtctgatat ccaattatac agctatacac 1258141 cgagatttga tgaaaatccg tattctaatg agaaccggac gtttaaaggt tttagaagag 1258201 aaaacggaga tgcgggtgta cggaatgaat tgtggattgt cccaactgtc ggctgtgtca 1258261 atggaatagc agaaaaaatg ctgcagcgtt ttgtcagaga aacaggggat atcgctccat 1258321 ttgataacgt actggtgtta aagcatcaat acggatgctc gcagcttggc gacgatcatg 1258381 aaaatacgaa gcagatcctg ctgaatgcca ttcgccatcc aaatgccggc ggcgtcttgg 1258441 tgttagggct tggctgtgaa aacaatgagc tggcaagaat gaaggaagca ctgcaagatg 1258501 tgaacttgaa gcgggtgaag tttctggaat cccagtcggt gaccgacgaa atggaggcag 1258561 gcgttgcttt gctgaaggaa attcatgaag cggccaaagg agataagaga gaagacattc 1258621 cgctgtctga actgaagatc gggctgaaat gcggaggttc ggacggtttt tccggcataa 1258681 ccgcaaaccc gctgcttgga cgtttttcag attatctcat tgcacaggga gggagtactg 1258741 tgctgacgga agtaccggaa atgttcggcg cagaaaccat cctgatgcag cgggctgcca 1258801 atgaagaagt gtttcataag atagtcgatt taatcaatga tttcaaacaa tactttatta 1258861 aacatgatca gccggtgtac gaaaatcctt caccgggcaa caaagcgggc ggcatttcta 1258921 cacttgagga taaatcgctg ggctgtacgc aaaaagcggg gatttctcct gtcacggatg 1258981 tcttgaaata cggtgaagta ctcaagacaa aagggctgac tcttttgagc gcaccgggca 1259041 atgatttgat cgcctcctcc gcattggcgg ctgccggctg ccaaattgtc ctctttacaa 1259101 cgggaagagg cacgccgttt ggcacctttg tcccgacggt gaaagtagcg acaaacaccg 1259161 agctgtatga ggcgaagccg cattggattg attttaacgc aggcctttta gcagaggatg 1259221 atgttcatga ggaatatgtg ctgcgtgagt ttatccacta tatgattgag gtggcaagcg 1259281 gccagcttgt gaaccatgaa aaaaatgatt tcaaagaact cgccattttt aaatcgggtg 1259341 tgacgttata ataagaaaag gctatccttc aagcggatag ccttcttcat taaatcaatt 1259401 ttaaaccgct gactaaaata atggaagcca taataaattg cagtggacgc ggggagaatc 1259461 gaggcgaaag atggctcccg atcagtacgc cgggaattga accgaggagc agattagctg 1259521 ccagcatgta atccacgctt ccgaagcttg cgttcaaaat gcctgctgcc gtaacaagaa 1259581 gaaaagcatg cgcgatatcg gttccgacaa tctgtgacgc tttcatgtta aataagtaaa 1259641 tcatggcgat tgcaaataat gagccggacc cgattgatgt taatccgacg ataaacccaa 1259701 acacaacacc aataagaatt gtcagcgccc tcttattttc aagcggcatc agctgccagc 1259761 ggttggggcg aagttttcta tccaaaaaca aacgaacgat gattgaaatg gcaaccagcg 1259821 ttaacacata tcctagagcg tgcttaataa tttcttcctg atgctggtga aaggcgggga 1259881 acaaatgcaa tatgccaatg gctagcgaag cactcggaat accgccgatg gctaagtatt 1259941 ttaccaattt aaagttaatc gttttctgcc gccaatggga ggcaacgcca aacagctttg 1260001 tgatcgagtt atatacaaga tccgtaccga ccgcgatgga aggattaatt ccaagcacaa 1260061 ttaaaagggg agttaataag gccgctccac ccactcccgt caatccgact aaggctccga 1260121 caaacaaacc catcaatatg atgcttacac tcatgataaa ggcctcctga aaacccgact 1260181 agaattcacc cgaatcttat tcgcgttggt caagtattaa ttgtaagtgc tccatcggct 1260241 gctgaaaaac ccgagctcta tccgctccct gatggtatca ttcaattgac aacaccttat 1260301 acatcaggag aacacgtctt tcaggtgcaa cgagcacttg cggctctgta tttttaccct 1260361 gataaaggcg ctgttaacaa cggaattgac ggcgtttacg gaccgaaaac agctgacgca 1260421 gttgcccgtt ttcagtctgt taacggtcta actgctgacg gtatctacgg gcctgcgacg 1260481 aaagagaaga tcgcagcgca attaagctga tcaaagacca taaaaatccc ggagccgctc 1260541 cgggatttat tttttcttct tcaacttttt tataattcca gcactgcgct ccctcacccg 1260601 aagcgagtac ccggaaagcc caaaccttcc gtaatcaaca aacttcacac gcctcaccaa 1260661 ttttttcact gtatcacctg acattatcct ctgtttgtat ttattatatg tcacccttta 1260721 agaaaaggaa taaggacaag agctgttttc ccttgtcctt ttagtgtgat catgcttttt 1260781 ttcgtttata ctcgtcaatc agccgttcgt tttctttgaa gattcttgct gtatgcggac 1260841 tgacttgata gcttgcgaca ctggtggttg aacgtttttt caggatttta aacggcttcg 1260901 ccgctctggg ctcgcatctg ttttgaaacg cacgttccat tatccttcac cttcctcctc 1260961 aattggcagc accaaatcat atatgctcgt taatgacgta aatagcaaat aatcaaattc 1261021 cgtgacaatg ctgtcagacg tcagcttgat gacatagttc tgtgtctcga tggtaaaagg 1261081 gatgagaacc acttttccgt attggtcgta ataaacatcc tttcgatcga gccgtgtttg 1261141 tacatctgcc ggatcatcca tatgctcggt taaccggtct ttatcagcct gtgtcgaata 1261201 gtggcaaaga gaagccgtta agttcatttt atcagcatag gttttcagca gcttatcaat 1261261 accttcagca taagcatcta tacttccata ataaacatgg atcggttcgt ttttcaatag 1261321 gtattggtat gttttcagcc gattgagata catgtggagc atttcgttgt tttcttcaag 1261381 aatttctctt gtgtctgttt caagctcgct gccggccagt tttttgacat atgcacttaa 1261441 gaagataaaa gcatcaatca aagcaaaact gactgcgaca atgagatacc gttcccagtg 1261501 ggtaaatagg gaagtgggct catatgtcca gtataccata gcgcccagaa caaacagcaa 1261561 ataccaagtt ttccgaatgg cggacatttt ttctttgacc ttcgcttcga aacgccacgt 1261621 ggcatacacg tataacccca gtccggccac gatgcaccag accatgatct gaaagaataa 1261681 aaccatattc gaatccctca catctgaaat aggttctgct tattgtattc gagagatccg 1261741 gatggttttc ctgttccatc aaaaaaaccg ctcctttgac agaagcggtg tgacattaaa 1261801 atatcatatt taaaataaag taggcgatgg caccaagtgt cgctgaaatc ggaagcgtga 1261861 tgacccatgt aatgagcatt cgcttggccg taccccagtt tacgcctttt acgcggtggg 1261921 acgcaccgac gccaagaatt gatgaagaaa tgacgtgggt tgtactgacc ggcaaatgaa 1261981 taaacgtggc gccgaaaata atggctgctc cggttaagtc agcggaaaca ccgtttaccg 1262041 gacggatttt catgatcttt ccgccaacgg ttttgatgat tttccagccg ccgattgatg 1262101 ttccgagacc catggctgtc gcgcaggcga attgcaccca ggtaggaata tcattagcag 1262161 aagtatgtaa attcgctgtg atgagagcca ttgtgataat tcccattgct ttttgcgcat 1262221 cgtttgttcc gtgtgtatac gattgcaggg cagctgttac aatctgcact ctgcggaatt 1262281 gcttattcgt tttcgccaag ttgctgtctt tgaaaatcag cttaacgatg ctataaagaa 1262341 taaaaccaag gacaaaggca ataattggtg atagaatcag tgcttcaatg attttaatga 1262401 agcccttata gtttaacgct gcaaatccgg ctgccgcaat ggctgcaccg gcaatagcgc 1262461 cgatgatggc atgggatgag ctgcttggga taccgtagta ccatgtgata aggttccagg 1262521 caattgcagc gagtagcgca gccaaaatga caacagagcc attttccagc gtataaggat 1262581 ctacgatgtc tttcgtaatg gttttggcaa cacctgtaaa cgtcattgct ccgacaaagt 1262641 tcatcacagc agccaatata atggcatggc gcggttttaa cgcttttgtt gataccgaag 1262701 tcgcaattgc gtttgccgta tcatgaaacc cgttgatgaa atcaaacgcc agagcacaaa 1262761 tgactattag tatcgttaat attaatagaa tatccatttt tacccctcgt tacgcgtttt 1262821 tcataatgat ggtttcaaga ttattggcaa cactttgaca agagtcggcg atttcttcaa 1262881 gcgtttcgta tatttcacga tattgaatga ctttgattgg atctgtttca tttccgaaaa 1262941 gattctttaa tgattttctg tgcaagttgt cacaactgtg ctcatactct ttaattttga 1263001 ttgcgtgagg ctgaatatcc tttaagcgat tttctgccag cagctcgatc gtaatcaaaa 1263061 tctctttcgc acattctctg atatatccgc tgaatttatc aatatgctcg tctgatgaag 1263121 taattgagaa aatctccatc atggcagaga aatgttcgat tccgtcaagc acatcatcca 1263181 agctgtttgt cagctgaagg atatcttcgc gctcaatagg agtgatgaac gctttgttaa 1263241 gctctttaat catgacatga acatgattgt caccttttgt ttcatattcc tttaacgtat 1263301 ctgcaaattc tttaagagtc gtttggttag tgaccttaaa attcacaaaa tattctgcag 1263361 tttcgtctat gttctttgca atttctgtta aaaggagtga gaacttatct ttttttcttc 1263421 ttatcattaa aaaccctcca tagtttgaat gaacaatgca cacatcaaat tattatatag 1263481 ccttttgtcg aaaaaaaaca ggtaaagtcg aaaaaaacgt atcttgactt ttttgataaa 1263541 tcgtgtctcc ttattttgac ctacttcgct ttaaaaaaac gacccaagtt tgcaaaaact 1263601 ttctgcttaa cgtaaaaagt atatcaaaag ttgtgttttt cctgtcaact tttatcttct 1263661 gtttcaccaa aaaacggttc cctaaacaag ggaaccgttt tatcagcttg cttttcgttt 1263721 tttcatcccg taataaacag gcagtccggc aaggccgatg aggatggata atccgcagct 1263781 cattgtatct gtaatgagtg tgctgcctaa cacaaagaag gagcccgcga ttgccagaat 1263841 tggcataaat ggataaagcg gaacactgta ggcgcgcttt tctccctttg ctcgcttgcg 1263901 gagaataaac actgcaaaaa aggccatcac ataaaaaatg tagatcatga aaatggagat 1263961 ttctgagagc ttatcagggt tgctgatcag catcataatc aaagccaaag caatttgaaa 1264021 agaaatcgca atccatggtg tgcggaacga cgggtgtaca tgtgacagtt tttcagcaaa 1264081 tggaagctgt ttgcgttccg ccattgcaaa tgaaacacgc gggaaagaaa gcacctttcc 1264141 atttaagcac ccaaagatgc tgacgataat ccctacactg atcagctttc cgccaattga 1264201 accgaacagc atggttgcag cggtgcttgt cgcattttca ccaagcgtga caatttcgtt 1264261 cgctgacagg atgtgaagca atgcaaaatt aatgaaaata tagatcgccg ttacaattaa 1264321 taatccgccc gtcatagcgc gtggcagcag cttttcggga tttttcattt ctccgccgag 1264381 agcggcaagg agaatccatc cgtcataagc aaacaacgta gctaaaatag ccgccccgaa 1264441 gttcatatca gaaatgcttt cgtttactgc tgtgaagatg tgctgatcgc ctttccaaag 1264501 gccaaagacg atgatgcagg caatcggaat cagttttccg atcgttgtca gcgtttggac 1264561 aaaaccgccg tattttgtac cgataatatt aatgacgcat aaaaagagaa ctgctataat 1264621 tccaatgact tttgatagtc cagatcccca gccgaaaaga ttcgccatta aagatccaaa 1264681 atataaaccc agcgcgccaa taatcgccgg gccgtaaatg ataatctgca cccagccgca 1264741 caaaaatccc caaaactcgc cgtacacttc ttcaaggtac gtataaagcc cgccggtttt 1264801 tggaatctgc gttccgattt ccgcgattgt caaaccgccc gccagtgtta aaataccgcc 1264861 taacagccag gcgaaaagcg ccatttttga atcacctgaa taagcaagca cagcgccggg 1264921 cttcataaaa acaccagaac cgataatggt tccgatgaca agagtaaggg caaacaagag 1264981 gcctatctct tttttcaaac cgttgtcttc agtatgcatg tccttaacct cctatgatgt 1265041 tgaagcttca tgttgaagaa tctatttttt catattgtaa accctatttt agaaaagtga 1265101 aataaaataa attttctgat tttcgaaatt tgctttgtgt acagcagata aaactgtaga 1265161 aatacctgtt ttaatggtct ataaacgaat aaaattcata atttttattt acaaagttcg 1265221 tgttttatgt attaggattt tagccggtac agaggggaga tgagaattca gaaaatgaac 1265281 gaaccttcgg tgaagctgat atgttgactt tctcatgcga ataaaatact ttgttattag 1265341 aacaataaat atacaattat gatatgatat ctcgaaatcg agataaaata acctggaggg 1265401 acagcatatg aaagttaacg gcattcacca cgtatcggca ttaacggccg acgcacaaaa 1265461 aaacttggat ttctataaga aagtattagg attaaagctc gtcaaaaaat ccgtcaatca 1265521 ggatgaaccg acaatgtacc atctgttcta cggagatgaa gtggcaaacc cgggaactga 1265581 gctgacgttt ttcgagattc cccgcattgc accgtttcat gcgggaacaa acagtatttc 1265641 ttctattgga ttgcgcgttc caggcacaga agccctgcat tactggaaag aacgttttga 1265701 agagcagcaa gtaacgcaca gcggcatctc caaaagagcc ggacgtgaca tattggcatt 1265761 tcaagatcat gaggggcagc gacttgtgct gactgctgat gaggaaggaa aaggatatgg 1265821 cctgcctgtt aaacagagcg gcattccgga agaattttcg tttcgcgggt tagggccggt 1265881 tgaactgact gtgccatatg ctgaaccaac tttacacgta ttgacgaata ttcttggatt 1265941 tacagaaatc agccgtgaac cagtcgaagg gcaaggaacc gccgttattc tggaatcagg 1266001 agaaggcggt gctgcaacgg aaatccattt aatagaaaga aacgatcttc cgcgagagcg 1266061 tcaaggcaaa gggagtgttc accacgtcgc atttcgggta agagatgaag aagaacttgc 1266121 cgggtggcac cggatcatca gccgcgaagg ctttagcaat tcaggcatag ttgagcgcta 1266181 ctatttcaag gcgctgtatt tcagagaacc gaacggcatt ttgttcgagt tatcaacaga 1266241 cggaccgggc tttatggtag atgaaaatct tgatgagctt ggccaaacga ttgctcttcc 1266301 gccatatcta gagcatcgaa gagcagaaat tgaagcaaaa ttgaaaccga tccaataaat 1266361 tgtgattctt ttgccttccg gcgccgccgg agggcttttt ttattaccat aattaatttt 1266421 gacctaaaca gcatgcctta ttagggagga aatatcagat gctgattggg agaaatggct 1266481 taaaaccctt tgcaaatatg ggtgattggt atggaatggc ctcggcaaaa atattgtctt 1266541 tgtttattaa tagtttattc atatttgctt gttacactat ttcaaagtta gacaaaaagg 1266601 agtgaaaaat aagtggaaaa gaaaaaacgc gagctggata tcgtcctcct cctcattttg 1266661 ctcgcatctg cattcttaaa tatctataac atttggaagg acgacacggt gaatccttat 1266721 tacaccgcgg cagttacaag tatgatgcaa agctttcata atttctttta tgcttcgttc 1266781 gatgctgccg gctttataac agtagataaa ccgcctgtta cataccaaat ccaaacgatc 1266841 agcgcactga tattcggtat gcacggctgg agcgtcatcc tgcctcaggc acttgctggt 1266901 gtaggttctg tccttcttat gtacttgctg ataaagccga catttggaaa aacggcggcg 1266961 cgtattgcct catttgttat ggcatgtacg ccgatagctg tagctgtagc acgtacaaac 1267021 aatgttgatg cattactggt atttttctta ttgcttgcta catggcttct ctttaaagcg 1267081 atcagaaaag gaaagctgat ctggctgtta gcagcatttt tcgttgttgg agtaggtttt 1267141 aatacaaaaa tgctgcaggc ttacatgatt ttaccggctt tcttattgtt ctatctgatt 1267201 gcggcaaacg ccacaatcaa gaaaaaaatc gtttcattgg taagtgcgtt agccgtatta 1267261 gcagccgttt cgttatcgtg gccgctcatt gttgacaata tccctgcaag caagcggcct 1267321 tatatcggaa gcagccaaac caactctgtt ttggaattgg ctttcggcta taacggaatc 1267381 cagcggctga caggccaaaa ttcaggcggc ggccagggtg cgccaaacaa agacgcttca 1267441 aaagaaatgt cttcttctga taacactcaa gcaccgccta atcagtcatc aagcaacagc 1267501 tcatcaagcg atggtaaatc ctcaaatggc aatatggcgg cgcctccatc caatggccaa 1267561 atgccaagcg gcggtcaagg aggccctcca agcggcggag atggcggcca aggcggaccc 1267621 ggcggagacg gagggaaagg cggtacagga accggttcga aaatgcaatc aggttcaggg 1267681 atgtttggaa cgggaacacc tggtccactg cggcttttcc aacaagagtt atctgatcaa 1267741 atcagctggc ttctgccatt tgcgatattt ggaatcgcag gcttactgat cgctggcgca 1267801 agagaaagaa gaagattatc tgtagagcag aaggaaacgg tgttctgggt tgcgtggctt 1267861 gtaccgattg ccggattctt cagtgtcgca gaatttttcc atcattatta tctcatcatg 1267921 ctggcaccgc cgattgcggc tcttgtcggt gcggggtggg tcgctcttgt tcatctgtac 1267981 cgcaatcaga caggctggaa agcatggctt ttgccgggag caattattgc gacaactgga 1268041 tttgaattgt ttattctcag aaactacaac gatcaaatcg gtgttggatg gagtatcggg 1268101 gtaggtgtta tcggcgtgtt gtcagcgatt gctttgctgc tgtttaaaca gcgccaaaaa 1268161 ccgttcagtt attatgtttc acttgcagct ctcctcgcat tgctggtgat gccgatgtat 1268221 tgggcaagta caccgcttct gtacggaggc aacagctcac tgcctgaaac aggccctcaa 1268281 ctcgcatcaa tgagcggaaa aggcatggga atgtctgatg cgactgtaaa tgaaaaactg 1268341 atcaaatatc tagaggagaa taactccgga gctgaatacc tattcgccac aaccgattcg 1268401 aacacagcgg caccatatat cattaaaacg aaaaaagctg tcatggctat tggtggatac 1268461 agcggttctg acccggcaat cacactgact caattcaaaa aacttgtaaa agaaggaaaa 1268521 gtgaaatact tcttggcttc tggaatggga agaggcggaa acaatgacat tgttgaatgg 1268581 gttgagaaaa atggaaaaga agtagcatca gaaaaatggc aatcaagttc tgatcaaaaa 1268641 acagaaaata ctgattcagc tgatacatca agcagcaagg cttcaggtga aaacggcaaa 1268701 atgggcggac ctggcggaat gaatcagtca gcaacattat acgaactaca tgctgatgaa 1268761 taggaggcaa aaacatgagc agacatattc aatattcaat tgttgtacct gtgtataatg 1268821 aagagcttgt cattcatgaa acctatcagc gcttaaaaga ggtcatggat caaacgaagg 1268881 aaaactacga gctgcttttt gtcaacgatg gcagcaaaga ccgcagtatt gagattttaa 1268941 gagagcacag cctgatcgat ccgagagtga aaattattga tttttcaagg aattttggac 1269001 atcagatcgc cattacggca ggtatggatt atgcacaggg gaatgcaatc gtcgtcattg 1269061 acgccgattt gcaggaccct cctgaactga ttttagaaat gattgaaaag tggaaggaag 1269121 gctatgaagt cgtgtacgcc gtacggacta aacgaaaagg ggaaaccttt ttcaaaaaac 1269181 aaaccgcggc tatgttttac cggcttctca gcggtatgac agatattgat atcccgattg 1269241 atacggggga ttttcgcctc atggacagaa aagtctgtga tgaaatgaag agattaaaag 1269301 aaaaaaatcc atttgtaaga gggctagtca gctgggtggg tttcaaacag acagcggtcg 1269361 agtatgtacg tgatgaaagg ctcgccggag aaacaaagta cccgctcaag aaaatgctga 1269421 agctgtcaat ggacggcatc acgacatttt cacataaacc gctgaagctg gcaagctatg 1269481 cggggatttt aatgtcaggt actggatttc tgtatatgtt tatcgtgctg tatctgaagc 1269541 tattcacaga cagcacgatt accggctggt catcacttat tgtgatccag ctcctgttca 1269601 gcggcattgt ccttctgatt ttgggcgtga ttggcgaata tatcggcaga atctacgatg 1269661 aagccaaaga caggccgctt tacatcgtcc aaaaatcgta tggaattgaa aataaaagac 1269721 tctatagaga ccagcatatg tcataacctc aaaccccctg tccgtaatgg acagggggtt 1269781 tttatgctct gagcacgatc taaagcaaaa gatgctgata gatatatgga aattgggtaa 1269841 agaagagatt gtgagcttgt actgcggttc agtcatgctg aaataaaaac agcaaaactt 1269901 aaagatttcg tcctcggctt tgctgcatgt cagctgttat attggggggc ttttaagaaa 1269961 cgcatgatta gagccgtacc agttatgttt aatagaatac tcgtacccaa tacaattccc 1270021 cacgtcaacg tcgattcaga gagaagaaag ctcagcaaaa gaaaagccaa tcctgcgcag 1270081 atcataccca gtcccacggt tttcatgttc atgcctccta gcaaacgatg tttctagcat 1270141 ctgatgtgaa tgatgtcaat ctgtatgata tacggatatc tcgtcagaaa gtttcataga 1270201 acaattaggt cttttatcta ataaaaagcc tcagaccgct tttacggcct gaggcattat 1270261 gtcttacgaa gttttctctt ctttttgatc cagtttaatt tttttcgtca tttctttgcc 1270321 gtttcggaga attttcactt caacggtatc accgatcttt gcgtctttat ataagatatt 1270381 gcgcaattca ctgcctgtat caatttcttt accttttagg ccgatgataa tatcctccgc 1270441 ttttaatccg gccttttcag caggagagcc tgaagcgacc tcacggatgt aaacgccttt 1270501 attcagctgg ctgccgaaca ggccgagtgt gccttcttgg taattttgcg gcacttgctc 1270561 tagatcaagc atgctgacac cgatatatgg acgttcaatt tgtcctttag acagcaattc 1270621 ttcagcaatc ggttttacgt cattgcttgg aatggcgaat ccgataccct caacatcatc 1270681 ctcactgatt ttcatactgt taatgccgac aattttgccg tctgtattta acaaaggacc 1270741 gccgctgtta cctggattaa ttgctgcgtc tgtctgaatg acgttaatgc tcgtttcgcc 1270801 ggctgatgta gacattgaaa ccgttctgtc cacgccgctt acaattcctt gtgttactgt 1270861 gcgggacagg tcttttccaa gcggatcccc aatcgcaata acggtctcgc ctgttctaag 1270921 atcagatgaa tcaccgaagt ttgccacttt tgtgacgtgg tcatcactga tttggaggac 1270981 ggctaaatca gttaacgagt cactgcctac cagctttgca gtaacctcag tgccgtcata 1271041 taaagatacc ttcagtgatg atgccccttc tacgacgtgg ttatttgtaa tgatataagc 1271101 cttgccattc tcttttttga aaatgacacc tgaccctgaa ccgctttctg tatcttcgct 1271161 ggaatcagaa gaactagagc cgaacaaaga gctgtttgat tgtgcctgaa gatttgtaat 1271221 accgacaatc gctggtgaaa ggtcttctac catatctgag attttagaag agtcctcgct 1271281 cttgaatgca gatgagctgc ttgagctttt tttagattca gaggaggtgc ttgttgctgt 1271341 aacagattgc gtttgctgct ggctggatga ttgttttgca gtgtcctgag aatcatggtc 1271401 accaagcggt gtaaacgtgt aaatgccaag agcaagactg ccgccgatca ctccgccaag 1271461 caacggtctg aaccatccga atcctcgttt tttcttctcc tgatcatgaa tgacattgcg 1271521 ggccgagtag gaggcgctct gatcgttctc tttcgttaaa aagacctcat tctcattacc 1271581 tttcgttctg ttttcatcac gatagttatc catcatgttc actccgtttc tctattttca 1271641 catgtctatt tatattgata ggtttatgac ttgagtttat cataaacaaa aactgtggga 1271701 taaaaatgaa aagattatgg gaaattgtga aaaagtgcgg aaaacggtac acttcatatt 1271761 gtatatgaaa ggactgagtc gatggaacag attggattga ttggatatgg cagcatggcg 1271821 gatatgatcg ctagacagct gttgaaacat gaacaaataa aagagaatga gctatttatt 1271881 gagacgagaa cgaaggggga gcggctgcgg gcactcatgt cagattatcc aaacgtatcg 1271941 gctgatccgt tggagaattg ggcaaatacg tgccaattga ttttgatatg cgtcccgcca 1272001 ctccatgtca tcgaaacaat gcgccgtctg tacccgtatg tgaacagaaa tactcacatc 1272061 gtatccatag ctgccggtgt gccgctgcgt cttttggagg cagaaacaga agccggtatc 1272121 tcacgtgtta ttcctgccat tacgtccgaa gcagaagccg gcatctcact tgtcgttcac 1272181 agtgaagcac tggctgcaga gaaaaaagaa cgtctgaatg aattgttatc ggttttcagc 1272241 cgtgtacggg aaatcaaaga atcgaattta gatgtggcca gcaatttaac gagctcggca 1272301 ccgggattca tagctgcaat ctttgaagaa ctggcactgt ctgccgtcag aaacagcagc 1272361 ctgtccaaag aagaagcctt tgattttctg attcattcgc tatacggaac tggcaagatg 1272421 ctgatcgaaa aaaatatgtc tttcgaggag acgctggaac gtgttgcaac caaaggcgga 1272481 ataacgggag agggagctga ggtgatacac gcctctgtgc cggacgtttt tgatgaggta 1272541 tttgaaagaa ccctgagaaa atatgaactg cttacagaac aggttggtaa acaaacatga 1272601 atccttgaaa gaggattctt tttttatcac tgaatgattg agatttttcc cagttatatt 1272661 gcatttttcc tcttttttta atataatttg ttagaatatt cataatttag taaaaaagga 1272721 ggagcgttat gaaattgtac atgtcagtag atatggaagg tatttcgggt cttccggacg 1272781 atacctttgt ggattccggc aagcggaatt atgaacgcgg acggcttatc atgactgaag 1272841 aagcaaacta ctgtattgct gaagcgttta acagcgggtg taccgaggtg ctggtcaatg 1272901 acagtcattc gaagatgaat aatctgatgg ttgaaaagct tcaccctgaa gcagacttga 1272961 tttctggtga cgtcaaacca ttttcaatgg tggagggact ggatgatacg tttagaggcg 1273021 ctttgtttct cggttatcat gcgagagcct cgactcctgg tgtcatgtca cacagcatga 1273081 ttttcggcgt ccgtcatttt tacataaacg atcggcctgt cggtgagctt ggattaaatg 1273141 catacgttgc cggttattat gatgtcccgg tattaatggt agccggggat gaccgggcgg 1273201 cgaaggaagc agaagagctt atcccgaacg tgacgacagc cgcagtcaaa caaaccattt 1273261 caagatccgc agtgaagtgc ttgtcgcctg cgaaagccgg acggctgttg acagaaaaaa 1273321 ccgcatttgc cctgcaaaac aaggacaaag tcaagccgct cacaccgcct gacaggccag 1273381 ttctgagcat tgaattcgcc aattatggcc aagcagaatg ggcgaatctg atgccgggaa 1273441 cggaaatcaa gacgggaact acaaccgttc aatttcaggc gaaggacatg cttgaagcct 1273501 atcaggcgat gcttgtcatg actgagcttg cgatgcggac atcattctgc taaaggggtg 1273561 ttttaggctt tggcgcgata catgataaag cgtttttggg caatggcagc tacgattttg 1273621 gtgattacca ccctgacttt tgttctcatg aaggtcattc ccggatctcc ttttaacgag 1273681 gagagaggca caaatgaagc cgttcaaaaa aatctcgaag cctactatca cttagacgat 1273741 cctctcattt tccaatacat tttctactta aaatccatca ttacattcga tttcggacct 1273801 tcaattaaaa aaccgtcgga cagcgtaaat gatatgctgg aacgcggatt tcccgtttcc 1273861 tttgagcttg ggatgacagc gattgtcatt gctgtgattt ctgggctggt gctgggcgta 1273921 atcgctgcac tccgccgcaa tggctttttg gactacgccg cgatgagtct tgcagtactc 1273981 ggcatctcca tcccgaattt tattctggca acattgctca ttcagcaatt tgctgtcaat 1274041 ctcaaactat ttcccgctgc gacatggacg agcccgattc atatggtgct tccgaccgca 1274101 gcgcttgctg tagggccaat ggcgatcatt gccaggctga cacggtcgag catggtcgaa 1274161 gttctgacac aggattatat ccgcacagca aaagcaaaag ggctttctcc gttcaaaatt 1274221 atcgtaaaac acgcactcag aaatgcactc atgcccgtca ttaccgtcct gggcacactc 1274281 gtcgccagca tcttaacagg aagctttgtc attgaaaaaa tctttgccat tccgggaatg 1274341 ggaaaatatt ttgttgaaag cattaatcag cgggactacc ccgtgattat gggaacgacc 1274401 gttttttaca gcgtcattct gattatcatg ctgtttttgg tcgatttggc ctacggtctc 1274461 ttagacccgc gcattaaact gcataagaaa gggtgaagcg tgtgaatctc cctgtacaaa 1274521 cggatgaacg ccagccagaa cagcacaatc aggtgcctga tgagtggttt gtcttgaatc 1274581 aggaaaaaaa tcgggaagcc gattcggtca agcggccgag tttgtcatac acgcaggatg 1274641 cctggaggag gctgaaaaaa aataaattag cgatggccgg actctttatt cttttatttc 1274701 tttttgtcat ggcagttatc gggccctttt tatcgcccca tagtgtcgta cgccaatcgc 1274761 tgacagaaca aaatcttccg ccctcagccg atcattggtt cggcaccgat gaactcggcc 1274821 gggatgtgtt tacccgaaca tggtatggcg cgagaatctc gttgtttgtc ggcgtgatgg 1274881 cagcactgat tgattttttg atcggtgtca tttacggagg cgttgccggc tataaaggcg 1274941 gcaggattga cagcattatg atgcggatta tcgaagtgct gtacggactg ccgtatctgc 1275001 ttgttgtcat tttgctgatg gtgctcatgg gaccgggact gggcacgatt attgtggcgc 1275061 tgactgtgac cgggtgggtc ggcatggcga gaattgtaag aggccaggtg cttcagatta 1275121 aaaattatga atatgtactc gcctcgaaaa cctttggcgc gaaaaccttt cgcatcatcc 1275181 ggaagaattt gctgccgaat actatgggag cgatcatcgt acaaatgaca ttaaccgtac 1275241 ctgccgccat attcgcagaa tcatttttaa gctttctcgg cctgggcata caggctccgt 1275301 ttgcaagttg gggcgtgatg gcgaatgacg gcctgcctac gattttatct gggcattggt 1275361 ggcgcctgtt ttttccggcc tttttcatat ctctgacgat gtacgcgttt aatgtgctgg 1275421 gggacggatt gcaggatgcg cttgacccta agctgaggag gtagctgtat ggaaaaagtt 1275481 ctgtcagtcc aaaatctgca cgtgtctttt acgacttacg gcgggacggt tcaggcggtc 1275541 agaggggtga gctttgattt gtataaagga gaaacctttg cgatcgtcgg cgaatccggc 1275601 tgcggcaaaa gcgttacctc ccaaagcatc atgggcctgc ttccgcctta ttcggcgaag 1275661 gtgacagacg gcaggattct atttaaaaac aaagaccttt gccgtctctc tgacaaagaa 1275721 atgagaggta taaggggagc cgacatttct atgatttttc aagacccgat gacggcgtta 1275781 aaccctacgc tgactgtcgg cgaccagctg ggggaagcgc tattgcgcca caaaaaaatg 1275841 agcaaaaaag cggcacggaa agaggtgctt tccatgctgt cattggttgg tattccagat 1275901 cccggagagc gcctaaagca atatccccac caattcagcg gcggtatgag acagcggatt 1275961 gtcattgcga tggcgctgat ttgcgagcct gatatcttaa ttgcggatga accgaccacc 1276021 gccctggatg taaccattca ggcacagatt ttagagctgt ttaaagagat tcagagaaaa 1276081 acggatgtgt ctgtcattct gattacgcac gatttagggg ttgttgccca ggtagctgac 1276141 agagtcgcag tcatgtatgc cgggaaaatg gcggaaatcg gcacaagaaa agatattttt 1276201 tatcagccgc agcacccata tacaaaaggc ctgctgggct ctgtcccgcg gctggattta 1276261 aatggcgctg agctgacccc gattgacgga acgccgccgg atttattttc gcctccgccg 1276321 ggctgcccgt ttgccgcccg ctgtccgaac aggatggttg tgtgtgacag ggtgtacccg 1276381 ggccagacga tcagatctga ctcgcacacc gtcaactgct ggctgcagga tcaacgagca 1276441 gagcatgcgg tgctgtcagg agatgcgaag gattgaacat gaaaaggggg aagaggatga 1276501 aacgagtgaa aaagctatgg ggcatgggtc ttgcattagg actttcgttt gcgctgatgg 1276561 ggtgcacagc aaatgaacag gccggaaaag aaggcagtca tgataaggca aaaaccagcg 1276621 gagaaaaggt gctgtatgta aataatgaaa atgaaccgac ttcattcgat ccgccgatcg 1276681 gctttaataa tgtgtcatgg cagccgttaa ataacatcat ggaggggctg acgcgtcttg 1276741 gcaaagatca tgagcccgag ccggcaatgg cggagaaatg gtctgtttcg aaagataata 1276801 aaacttacac atttacgatt cgggaaaatg cgaaatggac aaacggagat cctgtaacag 1276861 ccggagactt cgaatacgcg tggaagcgga tgcttgatcc gaaaaaaggc gcttcatcgg 1276921 cattcctagg ttattttatt gaaggcggcg aagcatataa cagcgggaaa gggaaaaaag 1276981 acgatgtgaa ggtgacggca aaggatgatc gaacccttga agttacactg gaagcaccgc 1277041 aaaaatattt cctgagcgtt gtgtccaatc ccgcgtattt cccggtaaat gaaaaggtcg 1277101 ataaagacaa tccaaagtgg tttgctgagt cggatacatt tgtcggaaac ggcccgttta 1277161 agctgacgga atggaagcat gatgacagca tcacaatgga gaaaagcgac acgtattggg 1277221 ataaggatac agtgaagctt gataaggtga aatgggcgat ggtcagtgac agaaatacag 1277281 attaccagat gtttcaatca ggggaacttg ataccgctta tgtccctgct gagctgagtg 1277341 atcagctgct tgatcaggat aacgtcaata ttgttgacca ggcgggtctc tatttctatc 1277401 gatttaatgt caacatggag ccgttccaaa atgaaaacat cagaaaagcc tttgcgatgg 1277461 ctgtggatca agaggaaatt gtaaagtacg tcacgaaaaa taatgaaaaa ccggcgcacg 1277521 cctttgtatc gcctgggttt acgcagcctg acggcaaaga tttccgtgaa gcaggcggag 1277581 acctgatcaa gcctaacgaa agcaaagcga agcagctgct cgaaaagggc atgaaggaag 1277641 aaaactataa taagcttcct gcgatcacgc ttacttacag cacaaagccg gagcataaaa 1277701 agattgccga agctattcag caaaaattga aaaatagcct tggagtcgat gtgaagctgg 1277761 ccaatatgga atggaacgta tttttagagg atcaaaaagc gctgaaattc caattctctc 1277821 aaagctcatt tttgcctgat tatgcagacc ctatcagttt tctggaagcc tttcaaacgg 1277881 gaaattcgat gaaccgcaca ggctgggcca ataaagaata cgatcagctg atcaaacagg 1277941 cgaaaaacga agccgatgaa aaaacacggt tctctcttat gcatcaagct gaagagctgc 1278001 tcatcaatga agcgccgatc attccggttt atttttataa tcaggttcac ctgcaaaatg 1278061 aacaagtaaa aggaattgtc cgtcaccctg tcggctatat cgatttaaaa tgggcagata 1278121 aaaactgatg gaggcgattg aggaaatact gcttctttat gcgaaggagc ggtatttttt 1278181 ctctttcttg cacgtatacg tagggtgcag agcaaatgaa aggagtgttt tcgttgaatt 1278241 acaagccgaa agcgttgaac aagggtgata cagtcggagt gatcgcgccc gcaagtccgc 1278301 cggatccaaa aaagcttgac accgcgcttt tatttttaga agagctcggt cttcaggtga 1278361 agttgggcaa ggcgctgaaa aaccagcacg gctatttagc gggacaggat gatgagcggc 1278421 tggcggatct ccatgagatg ttcagagacg atgaggtaaa agcagtgttg tgcgcatgcg 1278481 ggggttttgg gacaggacgt atcgccgcgg gcattgattt cagcttgatc cgcaaacacc 1278541 ctaaaatctt ttggggatac agcgatatta cgtttttaca tactgccatt catcaaaaca 1278601 caggtcttgt cactttccat ggcccgatgc tcagcacgga tattggcctt gacgacgttc 1278661 acccgctgac aaaagcgtca tataagcagc tcttccagga gacggaattc acctatacag 1278721 aagagctttc tccgctgacc gagcttgttc ctggaaaagc ggaaggcgag cttgtcgggg 1278781 gaaatctgtc tttgctgacg tctacactgg gcacgccatt tgaaattgat acgagaggaa 1278841 agcttctgtt tattgaagat attgacgagg agccttatca aatcgaccgg atgctgaatc 1278901 agctgaaaat gggggggaag ctgacggacg cggcgggaat tctagtttgt gattttcaca 1278961 attgtgtccc ggtgaagcga gagaagtctc tctcgcttga gcaggtgctg gaagactata 1279021 ttatttctgc gggcaggcct gctctgagag gatttaaaat cggccactgc tcgccaagta 1279081 ttgccgttcc gatcggtgcg aaagctgcta tgaatacagc agaaaaaaca gccgtaatag 1279141 aggcgggcgt ttcagaaggg gcgctgaaga catgaaaatc attcgaatcg aaacaagccg 1279201 aatcgctgtc ccgctgacaa agccgtttaa aaccgcactt cgcactgtgt atacggctga 1279261 atcagtcata gtaaggatta cttatgacag cggtgcagtc ggatggggag aagcaccccc 1279321 gacgttagtg attacaggag acagcatgga tagcattgaa agtgccatcc accatgtgtt 1279381 gaagccggca ttgcttggaa aaagcctggc gggctatgag gccattctgc acgacatcca 1279441 gcatcttctt acaggaaata tgagcgcgaa ggctgctgta gaaatggctc tatacgacgg 1279501 ctgggcgcag atgtgcgggc tgccgcttta tcaaatgctt ggcggatatc gagatacgct 1279561 ggaaacagat tatactgtca gtgtcaactc acctgaagag atggcagctg atgccgagaa 1279621 ttatctcaaa caaggctttc aaacgctgaa aataaaggtc ggaaaagatg atattgcaac 1279681 agatatcgcc cgtatccagg aaatcagaaa acgtgtcgga tcagctgtga aactgcgttt 1279741 agacgctaat caggggtgga ggccgaagga agcggtaact gccattcgga aaatggagga 1279801 tgcgggccta ggcattgagc ttgtcgagca gcctgtccat aaagatgatc tcgctgggct 1279861 taaaaaggtg acagatgcaa cagatacgcc gattatggct gatgaaagtg tttttacacc 1279921 gcgccaggcg ttcgaagttc tgcaaacccg gagcgcagac ttgatcaata ttaaattgat 1279981 gaaagcgggc ggcatcagcg gagcagagaa aattaatgcc atggcggagg cctgcggggt 1280041 ggagtgtatg gtcggcagca tgatcgaaac gaagctgggc attacggccg cggcgcattt 1280101 tgcggcaagc aagagaaaca tcacacgctt tgattttgac gcgccgctga tgctgaaaac 1280161 agatgtattc aatggcggca taacatatag cggcagcacg atttcgatgc ctggcaaacc 1280221 gggcctcgga atcatcgggg ctgcgctttt gaaaggggaa aaagagcaat gatgcacact 1280281 gtcatatcag cagtggccaa catctggaca gcgcctgatt cacctcgtcc gtctgatcaa 1280341 ttcatgcttc aaccgactgt aatgatcaga gactggctgg agcgcatgac gtatgatgaa 1280401 cggcttggat tatgtacaga caatgtaatc caaactcagg ttctctttgg cgaaaaggta 1280461 cttgtgacgg cggaacaggg ggaatgggtt tctgtgatcg tgcctagcca gccatcccga 1280521 aaggatccgc gcggataccc gggctggatg aaaaagtacc agctggaaaa aacaaagccc 1280581 atccatacac aacacgatgt gatgatcagc aaacctgctg cctttttgta cagaagcaat 1280641 ggggaaaagg agatcgaatt aagctttttg acagttctgc cccttattgc aaaagaaaac 1280701 ggatatttta aggtttcgac cgtttttggg gaaaggtttg tgaggcaaag tgatgcagtg 1280761 cctgtcagcc aacagaaagg gactgctgaa gacatcattc aaacgggtgc gttttttctt 1280821 ggccttccct acctgtgggg agggatcagc gggtttgggt ttgattgctc cggatttatg 1280881 tacagtatat ttaaggcgaa tggatacagc atcccccgtg atgcgggaga tcaggctaag 1280941 gcagggaagg gtgtcccgct tgatgatatg aaagccggtg atctgctgtt ttttgcttat 1281001 gaggaaggaa aaggagcgat tcatcacgtc ggtctgtatg taggcggcgg gaaaatgctt 1281061 cattctccaa agacagggaa gtcaatcgaa atcctcacat taacagagac aatctatgaa 1281121 aaagaattat gtgcggtgcg ccgctgtttt tcagaataag gagggagaca aatgaggcga 1281181 ctgcctttgt tagaggtcag ccagctgaaa atgcattttg acgcagggaa aaagcggaca 1281241 gtcaaagctg tcgacggggt cacctttcag attcgtgaag gagaaacgtt cgggctagtc 1281301 ggggaatcag ggtgcgggaa atcaaccttg gggagagtgc tgatgcgcct ttatcagccg 1281361 acagaaggaa gcgtgacata ccgcggcaca aatcttcatg cactaagtga aaaagagcag 1281421 tttgccttca accgcaaact gcagatgatt tttcaggacc cttatgcttc acttaacccg 1281481 cgcatgaccg ttcgagaaat tattttggag ccgatggaga ttcataatct ctacaatacc 1281541 cataaagcac ggcttctcgt cgtggacgag ctgcttgagg cagttgggct tcaccccgat 1281601 tttggcagcc gttatccgca tgaattcagc ggcgggcaaa ggcagagaat cgggattgcg 1281661 agagcactgt cgctgaatcc tgaatttatc gtggcggacg aaccgatttc tgcacttgat 1281721 gtctctgttc aagcgcaggt ggtcaacctg ctgaagcggc ttcaaaaaga gaaagggctt 1281781 acgtttttat tcattgccca tgatctttcg atggtgaagc atatcagtga caggatcggt 1281841 gttatgtact taggacacat gatggaaatt acagagagcg gcaccttgta tcgtgaaccg 1281901 ctccatccct atacaaaggc gcttttgtcc tcgattccga ttccagatcc tgaattggag 1281961 gacaagcgtg agcgtattct cttgaaaggg gagctgccga gcccggtcaa tccgccaagc 1282021 ggctgcgtgt ttcgtacccg ctgtccggag gcgatgcctg aatgtggaga atctcgtccc 1282081 cagcttcaag aaatcgaacc cggccgtttt gtcgcttgcc atttgtatcg aaatgctgaa 1282141 acgaaggaaa aagtaagata aataaaaaga gtggctcctt tttactagag ccactccatt 1282201 tgtttatact tgatgtaaaa actttacaca aaccgggtaa gggacagaaa ccgttgatgg 1282261 gaggagtgtc aatcggccgg tttctttgtc tctttcaaac aagacaaggt tgcctgtttc 1282321 ttcatttgaa gcaacgagga acccttccgt tgggtcaaat acaaagtcac gaggccagtt 1282381 tccttctgtc gacactcttt ctacgaaagc cagctctcct gaatattgat tcacttcaaa 1282441 tacggcgata ctgtcatggc cgcggtttgc gacataaaca aaacgtccgt cctgcgtgac 1282501 atgtattgcg cttccctggc tgttatctgt aaaatcatca gggatggcag aaacgacttg 1282561 gatttctcta aattcgccgg ctgtcgggtt gtattcaagc gcaatcactt cattgcttaa 1282621 ttctgtcatg acataagcgt atttttcttt cggatgaaaa gcgatatggc gaggtcctgc 1282681 accgggagcg aaggaatggc ttccggattc agtcaacaca ccgtctttaa gcttataggt 1282741 gtagagctta tctataccta aatcaaccgc taccacataa ttgtgttcag gtgtgaaccc 1282801 cgcgtagtgt gtatgcggtt tttcttgtct ttcgtgcggc ccttttcctg tgtgagcggc 1282861 ctctgaaaca ggtgattgca agctgccgtc ttcctgaacc ggaaaaacgt gtaccttccc 1282921 gctgtgataa ttggcagtca gtacgaattg attttgatca tcaacgctta cgtggcatgg 1282981 cgaagggcca tcaattaact gatgattcag aaatgtcaat tcgccgctgt ttttatcgat 1283041 ttgataggca gcaactccgc cttggccgtc tgctttttcg atggaataaa ggatggtgtt 1283101 gtttttattc gtcgccacat atgtcgggtt gcccagctta gcggccagct ttggctcgct 1283161 gagtgctttt ttctcagtat caagctcaaa tgaataaatt ccttcgcttc cgccttttgt 1283221 atatgttccc acatatccta tgtattttgt catgcgattt cccccttaaa aatgatgtca 1283281 cctctatatt aacgtatctt gataaaataa gctgttcaaa acatgaaaaa ggggaagatt 1283341 cttcattcgc ctcgaatcag cggcattgtg cagcacctga aggagccgcc tgatttaata 1283401 atttctgaca ggtcaatttc gataatgtga tagcctcttt tcgatagctg ttgattgaca 1283461 tggcggttgc cagggagact gatgatcgtt ttttttccga ttgaaaggac gttggtgcca 1283521 agcgtaaatt gttcgtcctc gggcacctca ataagatcat aacgttttgc cagcatatcg 1283581 gctgcatctg gctcaatggc ctgtgaataa attaacgctt cgctttcaga tataatgtta 1283641 aatacgcagt ccaaatgcaa aaatttttca tgaagcttca ctggaacgat cgtatattca 1283701 ggaagtgcct cttctagctg gccgatagct gaaatgtcgg tgcgctggct gattccgaca 1283761 tagacaatgt catcatcgat aatgacgtct ccgccttcaa tactcgtatc aagcatgcgg 1283821 gtgtaagaga taccttggct gtgaaaaaaa tcttttataa cggcttcttc tccttggcga 1283881 atcggttcag tcatgcttga cagaaaggct ttttctccga tgacaaatcc tatgtcccta 1283941 gtaaaaacct gttctgggag tccgtcgcga acgggcaaaa ggacgacctc aacgttgtgt 1284001 gacctaagtg cctccactaa gcggctgtgc tggtcgttag cggtttttac atgaatattg 1284061 tcatcttcaa aatgtttttg tgtttcgttt ataacatctt ttatggtcat gtgctcaggt 1284121 ttgcataaga tcactttttg aagtgtgccg tattccgttc ggcataccgt tttgtgctga 1284181 gatttcggga tggatacgtc catttgtttt tcctcctaaa gtgtgaagaa tacatttatt 1284241 attccctcat catgaaaatc attaaaccat tttaaatttt agacaaatgg aagagaatat 1284301 tgtttaatag gagaatataa gtgcatttag ctaaaagatc agacatcaaa ggggagaaag 1284361 gtatggaaac accggaaaca agattttgta aagagtcaaa ggttgtgaaa accagcaggg 1284421 tgttcccgct tgacacgaac aaccataata cgctgtttgg cggaaaatta atgagctaca 1284481 tagacgacat tgcctctatt tcagcggcgc gccattgcag acgtgaaacg gtaacagctt 1284541 caatggattc tgtagatttt ttaaagccga tcgggcaaaa ggattctgtc tgcctagagt 1284601 catatgtgac atgggtcggc acatcttcca tggaagtatt tgtgaaagtt attaaggagc 1284661 atttgatgac tggcgaacgg gaactcgctg ccacatcctt tttgacattt gtcgcattag 1284721 attcaaatgg caagccggtg cctgtaccga gggttgtacc ggaaacagaa gaagaaatca 1284781 tgctgcataa tacagctgta cagcgtgcta atgaacgtaa gaaccgcaag agacacagcc 1284841 aggcgcttgc aaatgcgctc ggaactgata agccttggtg aacgttaaac ccaaaacata 1284901 agttgttttg ggtttttttg tacttttcaa tggtgattat tacaatggtt agtccgtttt 1284961 tgctagggga ttctataaaa aagcaacaaa tgtcatgtta aattgataat tttgtgacaa 1285021 ctttattaaa gattcatttt agatatatct tttattcgta agatcatgta ttttaaagat 1285081 atattttaaa tacatctttt cgaaaggatt gtttataaaa tgttagataa caaaacaatc 1285141 gaaattatta aaagcactgt acccgtattg caacagcatg gagaaacaat cactggccgt 1285201 ttttacgatc ggatgtttca agaccatcca gagcttttga acatttttaa tcaaacaaac 1285261 caaaagaaaa aaacacagcg aactgcactg gcaaatgccg ttattgcagc tgcggcaaac 1285321 attgaccaat taggaaacat cattccggtt gtcaaacaaa tcggccacaa gcaccgcagt 1285381 atcggaatta agcctgagca ctacccaatc gtcggtaaat atttgctgat tgcgattaaa 1285441 gatgtattgg gagacgctgc aactcctgac attatgcagg catgggaaaa agcgtacgga 1285501 gtcattgctg acgcgttcat cggaattgaa aaagacatgt atgaacaggc tgaagagcaa 1285561 gccggcggct ggaaggagta taagccattc gttatcgcaa aaaaagagcg ggaaagcaaa 1285621 gaaattacat ccttctattt gaaaccggaa gacagcaagc cgttacctga attccaagca 1285681 gggcaatata tcagcatcaa agtgcggatt cctgattctg aatatacgca tatccgccag 1285741 tacagcctgt ctgatatgcc gggaaaagac tattatcgaa tttcagtgaa gaaagatggt 1285801 gtcgtgtctt cctacttaca cgatgggctg caggagggag attcaataga gatcagcgca 1285861 ccggcagggg actttgtttt agatcatgca tcacaaaaag atctcgtttt gatcagtgcc 1285921 ggagttggca ttacaccaat gatcagcatg ctgaaaacat ctgtttccaa acagcctgaa 1285981 cggcaaattc tgttcattca tgcggcgaaa aacagtgaat atcatgcatt gcgccatgaa 1286041 gtagaagaag cagcaaaaca ttctgctgtt aaaacagcat ttgtgtatcg cgagccgaca 1286101 gaggaagacc gtgcaggtga tctgcatttt catgaaggac agattgatca gcaattcctc 1286161 aaagaactga ttgccaacac agatgcggat tactatattt gcggttcacc gtcgtttatt 1286221 acggcaatgc ataagcttgt atcagagctc ggatcagcgc cggagtctat ccattacgag 1286281 ctattcggcc cgcaattaag tttggcgcag tccgtttgaa cacatacatg aaactcttct 1286341 cctttcagag aagagttttt tattgagata taagaaggca gacaagcgcc ggtttctaca 1286401 tccggacaat cacagacccg ctgccatttg tgcatacacg gttttgctgt tcttgcattg 1286461 ttctcagcaa ttcattgttt acctcaatcg ctctaattag ttgcttcatt cttagctcca 1286521 aaccggccag cctgtcgatt gtttgctgct ggtagccctc gggttgggga gccaatggca 1286581 gatcaaaggg ccaaagggta ttcgacttct gatttttcat attgcgtatt gcgcctccaa 1286641 tcggtgtcac tttctattat gttatgttca ggcgatatgc acgttcgcct agacactgat 1286701 gcatagaggg cctgccacgg ggcacaatag gctcaatatg accagcggat ggaggtaaag 1286761 atcggtgtta tggatggtat gggtattttt actgaagcca gttatcgtat tttcgattgc 1286821 atatattttg tttcggcttg ccggtaaaaa agctgtgtca caaatgaaca attttgacct 1286881 gcttttgacc ttcgcaatcg gaaccattat cagtgagccg atccttacat ccaagctgcc 1286941 gatgtcaatt tattatgcgg gtgctttttt ggtgctttat cttatcatga gcaagctctc 1287001 tttatctaat aaatggcgat ggctcctagt cgtgagcccg actgtcctaa tccgaaacgg 1287061 ggatattgat gaacgcggcc ttcgtaaaga aaggctgact gttaatgagc tgctcggaaa 1287121 gctgagggaa aagggctatg ccgacccggc tgacattgat cttgctatca ttgaagaaac 1287181 gggagaagta agcgtcatcc cgaaagagga agcgagagcg gtgcaggtgc gggatttgaa 1287241 tatggaagct gaacggaatt ttatcccgat tccgctcata ctggatggcg aaatccttga 1287301 tcataatttg aaatatctcc aaaaaaaccg atcctggctg tttgagaagc ttgaggaaaa 1287361 agggtacagc cccaaactgc tgtcttcgat tatccttggc acgatgaatg cacgcggtga 1287421 tatatccctt gatttaaata ccgctaatga accgcagcat gatccttact tatataaacc 1287481 gggaaataac aattaagatg gctctctctt gtaatgagag cttttttctt ttttaaaggg 1287541 aatttttgtt tggtgtcaaa tgtacctagt taggagggga actgaacatg aaggacttat 1287601 ccataagaaa cgacatggcg ccaacggtca gtttgctgta ttccgcagtg gaagaaaaca 1287661 gtctccgtct ggcttccatc gtaagccata tgacacacag tgaactttac tataaggggc 1287721 gctgccaaac aaaaaacagc acggctcagc ttttgcacca tatcacaaat gttgatatca 1287781 gatgggtctg gcgtatcaag gaaaatcgga tcccggacca tattgaacag gcatacggcc 1287841 cgatgacaga tgaaagcgga cggctgcctg aaccggtgaa tcagccagac ttagatgaac 1287901 tcctgaaaag acatcagcat gtagtagaga agctgaaatc ggtatgcttc actttaactg 1287961 aaaatgcttt gaaccagccg ctttccttcg aaggtgacac cgcgacgata cgatggggaa 1288021 tttggcatat ggcagatcat aaccgctatc atcaggcaca tattgaagct ctcaaaaaag 1288081 aatggaagca ggatgtggcg aagtatgaac gctaaaacga agcttgtgac tgatcgaatt 1288141 cgtttgcgct gtatggaaga tcgggatcaa gccactttgt ttgggctgct ttttaatgat 1288201 cctgacgtca tgacatatta ttccggttta aaagataaga ggcaaacccg cgagtgggtc 1288261 aattggaacc aacgaaatga aaaagggtac ggcgttagtc tgtggatcgc cgaagataag 1288321 cggacagggg agtttttggg gcaatgcggc atcgttcccc agcagatcga aaatcaaacc 1288381 gtaatggaaa ttggctatat gtttgcccgc cgccactggg ggaacggcta tgcgcaagaa 1288441 gcggctcggg cctgtctgga ctatggcttt aacgagcggc agttcggcaa aatggcggct 1288501 ttgattgatc cgggtaacaa agcgtccata cgggtagcgg agaaaatcgg catgcattac 1288561 agcaaaacga tcagaaaatg gaataaaccg atcgcggtat atgaaagaaa atcttacaat 1288621 tgaaagatag agctgagttt agtatcatga tatcatgtaa agttttctag ggttccgcat 1288681 gtcaattgac atggactggt ccgagagaaa acacatacgc gtaaatagaa gcgcgtatgc 1288741 acacggaggg aaaaaagccc gggagagtca atctcatgtg agacgactgt ccggggtttt 1288801 tttgttttcg gagaatctta atagatagaa aggaatgact caaaatgaaa tggggattgg 1288861 tcgtgcttgc cgctgttttc gaggttgttt gggtgatagg cttaaagcac gctgactcag 1288921 ccttaacatg gagcggcact gccatcggca tcatattcag cttttacctt ctaatgaagg 1288981 cgactcacag tctgcctgtt ggtaccgtgt atgccgtctt taccgggctc ggcacagcgg 1289041 gaacagtact tagtgaaatc gttctttttc atgaaccggt tggatggccg aagctattgt 1289101 taattggcgt gctcttaatc ggtgtaatcg ggttgaagct tgtgacacag gatgagacag 1289161 aggaaaaagg aggcgaggca taatgctgca ctggatcagt ttattgtgcg cgggctgttt 1289221 agaaatggcc ggcgtggccc ttatgaatca atatgcgaaa gaaaaaagcg tgaaatgggt 1289281 gctgttgatc attgttggtt ttgccgcttc attttccttg ctgtcgtacg caatggaaac 1289341 cactccgatg ggaacggctt acgcggtctg gacaggaatt ggcaccgccg gcggggcgct 1289401 tatcggcatc ctcttttaca aggagcagaa agacgccaaa cggatcttct ttatcgcgtt 1289461 gattttatgc tcagcagttg gtttaaaaat tctgtcataa attgattttt atcaaatctt 1289521 cagtataatg gataaatagt ttagacttac aaagataaga gggattattc atgaaatcat 1289581 atatgactca gcggttggac gaataccgtg acggaaatga ggataaaggt cggctcttgg 1289641 tcagctgccc cgatcagccg ggtatcgtct ctgcagtttc cgcgttttta tttgaacacg 1289701 gtgccaatat tatagaatca aatcaatata cgacagaccc tgaaggcggc cggttcttcc 1289761 tgagaatcga attcgactgc gcaggcattc gtgaaaaaaa atcatcactt caggcagcgt 1289821 ttgcctctgt tgcggaaaaa ttcgacatga catggagctt aactttggcg agcgaactga 1289881 agcgtgtcgc cattttcgtt tcaaaggagc tccactgcct gcatgagctg atttgggaat 1289941 ggcaaaccgg caacctgatg gcggagatcg ctgttgtcat cagtaaccat gaggaagcga 1290001 gagagctggt tgagcgcctg aacattccat tccactatat gaaagcgaac aaagacatca 1290061 gagcggaagt cgaaaagaag cagcttgaac tgctggagca gtacgatgtt gatgtgatcg 1290121 tgctcgcacg ctatatgcag attctaactc ctgattttgt ttcggctcat ccgaatcgca 1290181 tcatcaatat ccaccattca ttcctgccag cttttatcgg tgcgaatccg tacaaacggg 1290241 cctacgagcg cggcgtgaaa ctgatcggtg cgacatctca ttatgtgaca aacgatcttg 1290301 atgaagggcc gatcattgaa caggatattg agcgtgtgga ccaccgcgat aatgcggaag 1290361 cgctgaaaaa catcggaaga acaattgagc gcagcgtgct tgcccgtgct gtgaaatggc 1290421 atttggaaga ccgtgtcatc gttcatgaaa ataaaacaat cgtctttaac tagactgcaa 1290481 gaggcccgcg caatgcgggc tatttttgat gacaaaaaac cttgacaagt gtcttttttc 1290541 tttgcataat ataaaaaaat cattgagcgt tgaagaggat tagtaagcag acctttctgt 1290601 gacagagagc aaaatgaatc gctgaaacat tttgccgcat gaaacctgcc gaacctgcct 1290661 tggagtccta gggggaaaac ctaggcgcat aacctggcgt tacaggagag cggagcgtgc 1290721 acaagcgcgt tcaatcaagg tggtaccacg gaaacccatt tcgtccttat gaatcaggat 1290781 gaaatgggtt tttttattgt agaagagccg cggaggagaa taaatgaaaa aacaaagaat 1290841 agtagtgaaa ataggaagca gttcgctcac gaatagcaaa ggaagcattg atgaggcaaa 1290901 aatcagagag catgttcagg cgatttccgt gttaaaaaaa gcggggcatg aaatgattct 1290961 gattacctcg ggtgccgtag cggcggggtt ttccagcctc ggttatccat cccgtcccgt 1291021 taccatcaaa ggaaaacagg cggcggccgc ggtcggacaa acactgttaa tgcagcaata 1291081 tatgaatcaa tttaaacaat actcactgac tccgggacaa atccttttaa cgagaaatga 1291141 tttttcgaaa agagaacggt atcgaaacgc gtatgctacg ataatggaat tattagagcg 1291201 gggcgtcatt ccgattatca acgagaacga ttctacatct gttgaagaat tgacattcgg 1291261 agataatgat atgctttctg cgttagtcag cggattgatt cacgcggacc agctcatgat 1291321 tctcactgac attaacggac tgtatgatgc caatccaaat gaaaatcctg aggcgaaacg 1291381 atttgattat ttgccagaga tcacgcctga attgcttgga tatgcaggtt cagctggatc 1291441 aaaggtcggc accggcggaa tgaaatcaaa gctgttagcc acacaaaccg cgctgtctct 1291501 gggagtgaaa gtattcattg gaactggcag cggagagcaa aaacttgcgg acattttgga 1291561 cggcagggga gacggcactt atatcggaga caaagaacta tcttcggtta acaacacaag 1291621 gcagtggatt cagttccact cgccgatatc gggagaaatt atcattgatg cgggtgccga 1291681 agaggcgatg atccataatg gaagcagcct tttgcccgct ggagttgtgg gcgtgaacgg 1291741 aagctttccg aaaggggcgg ttgtggaagt caggggaccg ggcggcgtga tcggcaaagg 1291801 ccaaactcat tactcctccg aggagattat ggaggctaaa ggcaaacgca gtgacgaact 1291861 tgattttgag aaaacgtttg aggttattca taggaatgac tgggtcaatg taaaagacta 1291921 ggaggcggaa aaatgagtga agtttctgta aaagcgaagc tggcgaaaga agcagcagcc 1291981 gaaatgatca tgaaaacaac agccgagaag gatgaggcgc tcagcctcat tgcaaacgga 1292041 ctccgcaaag aactggattt tctcttggcg gagaatgcaa aagacattgt gaacggaaaa 1292101 gagaatggtt taacaccgga catcattgac cgtctctcat tggatgagaa acggatacgc 1292161 gatatcgcgg acgcggtgga gctcttaatc gacttagcgg acccaatcgg cgactctctt 1292221 gaaacgattg aaaaagaaaa cggcctgttt attgaaaaaa tccgtgtgcc gctcggtgtc 1292281 gtaggaatga tttatgaggc gaggccaaac gtcacagttg atgcggctac cctttgcctg 1292341 aagacaggga acgcggttgt gctgcgggga agctcctcag ccatccacag caacaaagcg 1292401 ctcgtcagtg tcatttacag agcacttgag caatcagcgc ttccgattca cgctgtgcag 1292461 ctgattgagg atacgagcag agagacagca aaagagctct ttacgttaaa tgatggctta 1292521 gacgtattga ttccgcgcgg aggcaagaaa ctgattgatc tcgttgtgag agaatcaaca 1292581 gttcctgtat tagaaacggg agcaggaaac tgccacatat tcattgacga aacagccaaa 1292641 ccgcaaatgg cagaaaaggt tgttgtaaat gccaaaacgc agcgcccttc tgtatgcaac 1292701 gcgattgaat cattgctgat tcacaaggct tgggcaagac agcacggaaa agaattgctg 1292761 gaccagctgg aaaacgcggg agttgaaatt cgcggtgatg aattggtatg tgaacttcat 1292821 ccttcaagca aacaagcatc aaaagaagat tgggaaaccg aatttttagc gcctgtcctc 1292881 agcgtaaaga cggttgaaaa cgtccaagaa gctgtaaagc atatccaaca atacggcacc 1292941 aatcattctg aagcgatttt aactgaaaat gacaaaaatg cggtatattt tcaaacggct 1293001 gtcgatgctg ccgctgtcta tcataacgcg tcaacccgct ttaccgacgg ctttgaattc 1293061 ggctacggag ccgaaatcgg catcagcacg caaaagcttc atgcaagagg accgatgggg 1293121 cttcctgcac tgacttctac aaaatacatc attaaaggaa ctgggcaaat ccgtgaatag 1293181 cggggtaatg ttcaatgaaa aagcttatct cattacgaga taagcttttt tatacgcgaa 1293241 aaattgacat ttcaaattta attgtgtaca atttaattgt ataaaatata ttgggggaat 1293301 gaaaaatgag tcagccatta tttaccgcaa ctgtttcagc ggtaggagga agagaaggaa 1293361 aggtcatttc atcagaccgc gttcttgagc ttgatgtcgc aatgccgggg acaccgagag 1293421 ccaagaaatt agaaaaagcg acaaatccag agcagctgtt tgcagcaggt tatgcagctt 1293481 gctttgacag cgccctgcag cttgtcgcaa gaacagaacg ggtaaaagta gagacagagg 1293541 ttacagcaaa tgttagcctg ttaaaggatg aagcggacca gggctataag ctgggtgtga 1293601 cgctgcaagt aaaaggagaa ggagtcagtg catcagaatt ggaggcgctt gtgaaaaaag 1293661 cgcacggcgt ctgcccgtac tcaaaagcaa cctccggaaa tattgatgtg acacttgaag 1293721 ttgctgaata aataaaaaga ggatgcctgt acaaggcatc ctcaattttt ttgatgaagt 1293781 gtttccagta atgtatatag agcggacttt aactgtttga gatcctcccc agactgcttt 1293841 gagagcccca gaattgtccc tggaatgtca accgcttttt cttttaataa cgctccgtcc 1293901 tctgtcaggc tgatcaacac ggaccgctca tcctcttcag atctttttct cgtaatcaaa 1293961 ccctgttgtt ccattcgttt aagcatcgga gtgagcgttc ctgaatctaa atacagctgt 1294021 tcgcccattt ttttgacagt aagcgtttca tgttcccata acaaaagcaa agccaaatat 1294081 tgagggtatg ttatattcag cttatcaagc agcggcttgt attgctttgt catctcccgc 1294141 gaactcgcat atagcaaaaa acaaagctga ttctccaatt tcatatgatc aaatttattt 1294201 tccattttgt tcaccaactc ttttttgtca ttcgattcta ttgtatctga aaaacctcac 1294261 ttttcctatt ctcggcaaac atagcatgtt taaaaagatc agaaagggaa atataacaac 1294321 tagatacaaa taaggaggtt gggaaatatg gcactattta cagcaaaagt aaccgcgcga 1294381 ggcggacgag caggacatat tacatcagat gacggtgttc ttgattttga tattgtcatg 1294441 ccaaatgcca aaaaagaagg acaaaccggc acaaatccgg aacagctctt tgcggcaggg 1294501 tatgctgcat gcttcggcgg cgcgctcgaa cacgtagcca aagagcagaa tatcgaaatt 1294561 gattcggaga ttgaagggca ggtcagcctc atgaaggatg agagcgacgg cgggtttaaa 1294621 atcggtgtca cacttgttgt gaacacgaaa gatttagatc gggaaaaggc acaagagctt 1294681 gtcaacgccg ctcatgaatt ctgtccttac tcaaaggcaa ccagaggaaa tgttgatgta 1294741 aaactagaat taaaataatg accggcatcc tgaggattct caggatgttt tttggtgtcg 1294801 gacatgcggg gcgggcacag atttatgata aaacttcaga gaagcgtttg aagcatgcct 1294861 ttaaaccaaa agttacagat gaagcgggtg gctggcacgg tgtctgccgt gctgaattgc 1294921 gcgtatatgc tgttttgtat ttgcacaggg catagcggct acttggagaa ataacaagga 1294981 ccaggccgcg catgcctgat ccttttaata ttctttctta ttggcgaagt tccgccatgc 1295041 ttgaaacggg gataaatgct ctgttagtgt cacttgataa aaggggatcg ttctttcttc 1295101 agcaggttta tcaatttctt tataaatgaa tgaatcatca aacccggctt cggcagcgtc 1295161 tgtgtgctca gctgcataga aaacggcttt aggccgggcc cagtagatgg cgcccaagca 1295221 cattgggcat ggttcacagc tcgtatacaa aatgcagtca tcaagctggt aggctcctag 1295281 caccttacag gctttccgaa tagctgtgac ttccgcgtgg gcagtcggat cattgcttgt 1295341 tgtgacgttg ttctgtccct ctgcaataat ggctccgtct ttcacgataa cggctccaaa 1295401 aggcccgccg attcctgcat tcactccttc acatgcgaga gtgacagccc gttttaagaa 1295461 cgtttcatga ttcatcccaa tccctcctgt caatagagtg ttattagtat agccgaaaag 1295521 aatgcaaaga acattcttaa aaaagtgcaa aataaacaaa gtatttgggg gatttgctaa 1295581 ataagaaacc gattgtggct gtattataga aaaaaaccat ctgccaaatg cagatggttt 1295641 tttcaaatta tactagctgt gtctgctgtg ctcttgcctg ttttgcggct tcaaccatat 1295701 ttttcaatgc tgcaaccgtt tcttcctgct gtcttgtttt caatccgcag tctggattta 1295761 cccagaagcg gtcagtcgga cagacggcaa gcgcatcaac gataatattg tacatttctt 1295821 cagttgacgg cacacgaggg ctgtgaatgt catatacacc aaggccaagc cctttcaaat 1295881 acgggtggtt ttttaagtaa tctaaaaatc ctccgtggct tctgctatgt tcgattgtaa 1295941 tcacatcggc atcaagatca ttgattgtat caacgatatc ttcgaagttg ctgtagcaca 1296001 tatgtgtatg aatttgtgtc tcgtttttca cggaagaagt ggttaatctg aaagcttctg 1296061 ccgcccaagt caaatactca tcccaatcgc gggttttcaa tggaaggcct tcacgcagcg 1296121 ctggttcatc gacttgaatg atttgaatgc ctgcgtcttc aagcgcttta acttctttgc 1296181 gaagggcaag cccgatttgg aaggcgattt ctttcctcga gatgtcgttt cgagggaaag 1296241 accagtttaa gattgtaacc gggcccgtca gcattccttt cacatgcttg gaagtcaatg 1296301 actgtgcgta gactgtgtct ttcactgtca tcggttcaat aaattcaaca tctccgtaaa 1296361 tgactggcgg gcggacacag cgtgagccgt atgattgaac ccaggcatat ttagtgaagg 1296421 cgaaaccggc cagcttttca ccgaagtatt cgaccatgtc tgtccgttca aattcgccgt 1296481 gaacaaggac atcaagctcc aattcttcct gaatatcaat ccatcttttt gtttccgcat 1296541 tgataaagtt ttgatactgt tcatcggacc actcagcttt ccgccatttt tggcgtgcgc 1296601 tccgcacttc agcagactgc gggaagctgc cgatcgttgt cgtcggcaaa agcggaaggc 1296661 cgagagattc attttgtagg gctaaacgtt cttcaaacgg aatcgggcgc ttgaagtctt 1296721 tatcagttaa ttgctcaagc tctttctttt gttcagaatt ggcgcctgtt gcaaactgtt 1296781 taagcgcctg gatatcagcc ttagcctgct gaatctcttc gctgatcgcc gcttttcctg 1296841 atactaagcc ttctttcaaa gctgtcagct cggccagctt ttcttttgcg taggataatc 1296901 cgttcaatag gtctttttcc aaatgctcat cagggtgttt cgctactgga acatgcagca 1296961 ggctgctgga aggctgaatc cacagttcat caacttttgc aatgctgaga atatcaagaa 1297021 cggcatcgag acgctcttca aggtccgctt tccaaatgtt gcgtccgtcg ataacgccgg 1297081 ctgccagcac tttatctgtc gggaagccat gtgttttaag ctgttccagg tttctgcctt 1297141 tgtcgtgaac gaaatcaagg ccaattccct gaaccgggta agagatcagc tcttcataag 1297201 catcaacaga atcaaaatac gtctgcaaaa gcacattcaa ggatgaaagc tcacttgtaa 1297261 tgctttcaaa taattctttt gcgccgcgta catcttcact agaggcggta acgagcgccg 1297321 gctcatcgat ttgaacccat tttacgcctt cttcttcaag ctctttcaaa agctgtacat 1297381 ataatggcac aaggcgtttt tggatcgctt ttgcttcaga cggttcatag cctttagcaa 1297441 gcgtaacgaa cgtataaggg ccgacaatca caggctttgt ttccacaccg tattcctgtt 1297501 tgatccggcg ataatcttcg agttgtttgt ttcttgtcag acggaactca atgctctcgt 1297561 catattccgg aacgatgtaa tggtaatttg tattaaacca ttttgtcatt tcactagata 1297621 cagcgtcttt gattccgcgg gcgatagcga agtatgtatc ggtagcgtca gtcaaatgtc 1297681 tgaaccgttt cgggatccag ttgaagctga ctgctgtgtc gagtacatgg tcatactgtg 1297741 tgaaatcaga aacaggcaca acatcaatct gctggtcaat ttgtgttttt actgcggata 1297801 aaaatagttc gtcgatttgc ttcaaaaacg tatctttatc agtactgcct ttccaatacg 1297861 cttcaagtgc ttttttccat tcccggttca gtccgattct cggaaatcct aaattcgatg 1297921 ttttgatggt tgtcattgtt tctcctcctt tatatgtaaa acactctctt tcacccgcgg 1297981 atacaggctg ctaagaggtt ttctcacaac aaaaagcctc tttcccatga gagaaagagg 1298041 cttttctacg taaaacactg cctctctcat ctctcagaca caatctgatg gaattagcac 1298101 cgtgccttat gagacatcag tctcggcgcg aaaagcagtg cgccccattt cacaatggta 1298161 ttacggtcgg ttgctgttgg ggtcaaaagg ccaatccctc gcccaactct cgataagaga 1298221 aaatgttatt aattttttga aaagttgaat catttgttgg taatcttaac agtaattcaa 1298281 attcattgtc aacatagaat ttgaaatttt tatttacatg atgtggtgta tattatataa 1298341 gaaaaataat cttatagggt caacaaatgt gattgctctg ctttttctgc gagctcatca 1298401 ggagctgtta aatacaggaa tccattgcct gccagcgttt ttgcaatatc aagaggaagt 1298461 gtcctgcgga ttagctgtgc gaaaacctca gattcagaaa gctttctttg aaatgattct 1298521 tcttcatagc ttttgattaa agcaagcgca ccgctgacat gaggggcagc cattgaagtg 1298581 ccggtcagct taccgtactt cttgttggga agggtggata agatgttttc tcctggtgcc 1298641 acaaggtcaa tctctttatt cgcgttagaa aattctgata attctcgcgc tacagaaaca 1298701 gatccaactg caatcacttc attataagct gcggggtagg aaagctcttc tgtgcgttcg 1298761 tcgccgtcac cttcatttcc cgctgcacaa acgacaagca ctccgttttt cactgcgttt 1298821 ttcactgctt cttttagctc tggcacatcg cttggccctc caagggacat tgagatgatg 1298881 tcgactttct gttccaccgc gtagttgatg ccgttaatta tccattcgta ttgtccgctg 1298941 ccgttctcgc cgccaagaac cttcacaatc aataggcttg cctcaggcgc gactccggca 1299001 atgcctccgt ttgaatcatt agctgcaatt gttccggcga cgtgtgtgcc gtgtccgttg 1299061 tagtcggaaa tcgcatcttc cttgccgccg tcgtcatccg tgaagttctt tccgccgatg 1299121 atttgatttt ttaaatcagg gtggcttgtg tcgcagcctg tgtctaatac agcaacttta 1299181 atatttttgc cttttacccc ttttgcccac atttctggcg ccttaatcac tttaatgccc 1299241 tcaggaagct cgtttacatc catgatctgc tcattcgtca catacgggat caagcggatt 1299301 tcaccattca taaaaaagcc ctcctttttt atgcttgcaa gtggattcaa gggtgttgcc 1299361 tcatattata tgaaaaaagc aagcgctcgg acagagccat ttgaagcatt ttgaaaaaat 1299421 aggatacaca ccaaagaatt agtaatcttc aaaatattgg atggcttcaa catgtatgac 1299481 tgggattcaa ctgtaagtca agttataata gtgttgggga aaggagcagt gtcatgaaac 1299541 tgaatgaaaa attatatgca tttttttcag agcatgtgga acaaatggcc gaggaatgga 1299601 ttgaaacgat ggaggaaagt gatccgaatt cgctttacgc cctacataat gcaacagtaa 1299661 cggaagaatt gaaagagcag gacagagaat tttaccggca tctgaattac atgtatgttt 1299721 taccggaaaa acaatttctc gaagagtttc aagagtgggt cattgagctg accaacgatc 1299781 aaaaacatct cgacacaccg gttcagtatg tcattcggga gtttatgaga aacaggagat 1299841 tatatacgaa gtattttgag aagttcgcag aagaaaatga atcagcgttt gaaccgggag 1299901 agaagcaaaa atgggcagat ttgattgtaa aagtatttga tttcaccatt tatacattcg 1299961 ttgatcacgc tgaaatgaat gccaagcagc aattaaacgc ccaaagagaa atgatattgg 1300021 aattaagctc acctgtcatt accctgagca aatcaacagc tctgctgccg cttgtcggtg 1300081 acattgatac cgaacgggcg aagtttattc tggaaaacac gcttcaagct tgtgcgaaaa 1300141 gacgtgtgga gcatctgtta atcgatctgt caggtgttgt tgtggtggat acgatggtgg 1300201 cgcaccagat ctttaaattg attgaggcgc ttaatctgat cggtgtccgg tcaaccctgt 1300261 caggaatcag gcctgaaatt gcgcaaactg ctgtacagct ggggattgac ttttcgaata 1300321 ttactattaa aaccaacctt gcccaagcat taaactatca tcaataaaaa aatccgctat 1300381 ctgtgatagc ggatttttta tgatgcgaaa cataaagata cgagaaagga tcccgcgaat 1300441 aataagagga cgaggcaaaa gaacacccag tcgcgccggt tcacgctcaa tgtcctgtag 1300501 tatgtccggt ttctgcttcc tgtaaatcct ttcgattcca tcgcaagcgc tgtccgttcc 1300561 gcttttctga tggcgcttgc caatagcggt atggtatatc gttttaacgc actgatttta 1300621 ttaatgatgc cgctctccgc cgctcctcct ctgattttat gagcctgctg aatcagctgg 1300681 acctcatcct ttaacagcgg aagaaagcga aagcctgcaa tgacaccgta cgcgagcttt 1300741 ggtgagagcc tgcactgctg gacaaggctc agcataaata gaatcggatc ggttgtaaaa 1300801 acaaacatca tcgataaggc ggaaaagcat aaaatacgaa acccgagaga gatgccgaca 1300861 gacacattat cgctgttaat ggagataggg cctgcttgaa acaaaaaatt atccggtgtt 1300921 gtcggcactt ttccaaaaac tgcggctgtc cacacgcatc cgaatgctaa aatcaaaaac 1300981 ggaatcgtaa acaacaacca ttttttcaat gggattccgg ccgccagtaa aacgcccgca 1301041 acgatgatga tataaaaaca tgccggagtg taagggttgt aaataaacga cagcatgacg 1301101 acacaacaaa aaaccgccgc cgctttcaca gtcggattaa tgagatgtaa cggttgcttc 1301161 atcacgcacc tcctcttgaa atgccatcca ttcatataga aggggaaggg tgagctttgc 1301221 tttttgaaca agccctgttt cttgagaaaa caactgcgct ggagatccgt caaaggccag 1301281 gcctgtatcg tgaagcacaa gcacgctgtc agcatacgaa gagactagct ccatatcgtg 1301341 tgtaatcata aggacagcag ttccctctgc cttgatacgt tgaatcattt ccatgcattc 1301401 agccgccgtg cgggcatcct ggccaaaggt tggttcgtct aataataaaa cctttacgtc 1301461 atgcatgagc atagtagcta cgctcagtcg ccgtttttgc ccttggctga tcgcaaacgg 1301521 atgatgatca gccaaatgcg caagaccaaa acgctgcagc aggtgttgcg cttttttctc 1301581 agtttcagca tttgctttct ggccgaacag aagctcgtca tacaccgtat cggtgacgaa 1301641 ttgatgctca gggttttgaa aaacaaatcc catccgttta cgcaattctt tttctttata 1301701 tttctgcagc ggctgatcat agagaaggat tttgccgctt tgcggtttca tgagactggc 1301761 cagaactgat aggagcgtcg attttccagt tccgttcgga ccgacaagcg ccgttaaaga 1301821 gccttcgcgc aacgaaaagc tgatgtcttt gaaaatcgcc tgctgtcctc tcgcgaacga 1301881 aaggctgctg acttcaagca cactctcccc agaaggggct ttcttctttt tgacatgccc 1301941 ggcaggaata ggctctttga acagcatctc ttttgataaa gtaaacggca tactcagctt 1302001 ttcctgcaga tgacagacct ttggaatggc gatgcccaat ttctttagtg tctccgcttc 1302061 atgctgaaat agatttttcg tcaggccatc cagtgccttt ttgcctgatt tgtcgagtac 1302121 gatcgttctc tcaatccaag gcgcccattc atcaagctgg tgctcaatga cgaggaggct 1302181 gaaacctttt tcccgctgaa gatccttcat cagatgaacg aactcccgag ctgagaaagg 1302241 gtctaaaaga gaggtcggct catctaaaat aataagctca ggctccatcg ccaaaataca 1302301 ggcgagagcc actttctgct tttgtcctcc tgaaagggtt gagatcattt tttcttttaa 1302361 atgggtaatg cgtaattttt ctaatacggc gttgattttc tctgtcattt cttcttttgg 1302421 aatttgcaga ttttccagcc cgaacgctat ttcgtcctcc accgtcagca tgcagaactg 1302481 ctgatcagga tcctgaaaaa cgaccccggc atgctgagta atcgtttcgg aggtttcagc 1302541 atctgtgacc ggcttttgaa atagaaatac atgtccggac tgaatgccgt cgcaagcctc 1302601 cggatataga ccgtttaaac aaagggcgag cgagctttta ccgcatccgc tcggtcctaa 1302661 taataaaaca cattctcctt tttgaagctc aaacgaaatg tcttgaaaaa ccggtttctc 1302721 gtcttcttca taagagaagc tgagctgctc aaccgtcaga agctcatcaa aggcttgcat 1302781 gttctgacgc ccgcttccgt ttctttttca gttcctttcc gagtgccatt ccgtttaaca 1302841 cacctgtata agcgagagag tcgctgacag cttttccgag aagccccgcc aaaagcgcgc 1302901 cggaaatgag gcggatcaca agcataatga gcagataacc tggtgaatag gctgcatagc 1302961 cagaaacaaa gagatcatag ataaagctgg ctactgaaga ccccataccg gccagcataa 1303021 ggacagggag agagtatgct ttccagcgtg ttgcaagaaa tacagcctca gccccgagcc 1303081 cttgaacaat gccaatgacg atgaccatcg ggccagacgg atttcccagc aggcactcaa 1303141 cgagagcggc aatgatttca gaaacgagcg ccgcacccgg ttttcgaatc atgtacgcgg 1303201 cgatcacaga aacgataaac caaatgccgt aaattggttc ataggcgatt ggcccaaaca 1303261 tacctgcaag tacgtttccg aaatgtgtaa ataataaata aacaacggca aatacgatac 1303321 tgataacgga catgatgaca atttctttta ctttccagct tttcatgtta tccctgcttt 1303381 ctgttttttc ttgatggact gttagccgaa agattcacag tcatggtgat gtggtttgtt 1303441 tgctgctcag ccatgcggaa aacggcctcc aatgtgctga atacgtcatg cgcatccccg 1303501 tcaagctcgc tcgcgtaatg gacaccctgt acgaaagtgc cttgggcttt tgcaatgtcg 1303561 acagcctcca taatcaatcc catataatcc ggctcattca ttggataaag ggcaaattgg 1303621 cacggcgctt ccgccttcaa gcctcggaca gcatcttcat tgacacgctt atcacctttg 1303681 gaaagatatg tatccccctg tgtgtcaccc gggcatccaa tggaaaacgt gccgttcatg 1303741 acgatgtgtt gttcgctgtt tgctgcatga aggtaaatgg cttttgcagc atcgaataca 1303801 tgatcaatcg atccgcgtaa caccgtgctg atatggtcgg ttttcgtcca aaccttggat 1303861 gtatctgttt ttttcagcgc agacttgatc acactgataa aatcatccgt catcggatat 1303921 aaagagaagc gaaaaccggc gattctgctt gtaccgcaaa tatgctccat ttctccgacc 1303981 tcctgttttt ttggtaaaat aaaaaactgc atatcctaag ggaatatgca gtcatagatc 1304041 gattaagcgc acaaaaaaat acaccattcg gtcaacctgc acttccccac gctggtatta 1304101 tccagatcgg gtcataaggg atcaaagcgc gtttcttccg cgctttatct cagccaaaac 1304161 agcaccccta gtgctttccg tatacaattt tttattttga catcataata gatgataaga 1304221 atcattttgt aaacaacgaa atcatttttt tcatataggg acgggagagg atggtcaaat 1304281 ttggaaaaag gacacatatt aattgtggaa gatgaagaaa aaatcgccag ggttcttcag 1304341 cttgaattgg aatatgaagg atacagcgtc acgatcaaac acaatggcac agaaggtctt 1304401 gatgcggcag cggaaggcgg gtattccttg gtgcttcttg atgtcatgct tccggggctt 1304461 agcggactgg aagtgctgcg ccgcttgaga aaaacggatt cgcagacacc ggtcatatta 1304521 ttaacggcgc gagacagtat tcctgataag gtaacaggtc tggacatcgg tgcaaatgac 1304581 tatgtcacca agccgtttga aatcgaggaa ttgcttgcga gaatcagggc ggcgctgcgg 1304641 caaaatggaa caaaaactga agatatcggc acctttctta catatgacga tttgcgggtg 1304701 aacgaaaaaa cccgtgaagt gagacgcgga gacaaagagg tggaattaac gccgcgggaa 1304761 tttgatctgc tcgtctatat gctaaagcat ccgcagcaag tgctgacacg ggagcaaatt 1304821 ctaagctcag tatggggatt tgattatatc ggtgatacaa atgtcgtgga cgtctacata 1304881 agatacatca gaaaaaaact ggactatcct tacgaaaaac agctgatcca tacgattcgc 1304941 ggggtcggct atgccattaa ggggtaaacg atgaagctga agaccaagat tcatctatac 1305001 acttcgatat cactgttgat tttattaatt ttggttcata ccgcagtata tctcattttt 1305061 tcgtctgcgc tgacatcaaa ggatgcggcc cggcttgctg atgagacgga taacattgcc 1305121 gaagcgctgc gtgccgctga aacagaagga gtggctttgc aggatatgct gcaggcctat 1305181 cttccggcaa atggcatggt gcgtgtagtg aatggtgatc aaaaagccgt tatgacgatc 1305241 acaaaagaaa aagcctataa agattttcct ctctcttttc atagcggcga aacggcagat 1305301 gtgaggaaac ctgacggcaa gctgtttgcc gaggctgctg ttccggtgat ttggaccgat 1305361 ggacaagtcg tgtctcttca gctggttgaa agactggaga acacagaaga gagtctgttt 1305421 ctgctgaaaa tcatcttaat cgctgcaagt gctgctgtct gcattgcttc tttttttgca 1305481 ggcagcttgc tagcccgccg aatcatcaat ccgatcagac gattaatgat cacaatgaaa 1305541 gacatacagc gagacaaaga atttaaaacg atttctttag aaggacagtc caacgatgaa 1305601 ttgtatcaaa tggggctgac atttaatgaa atggcaatga tgctgaagga gcactatgat 1305661 aaacagcagc aatttgttca agatgcttca cacgaattga aaaccccgct cactattata 1305721 gaaagctaca gcagcctgat gaagcggtgg ggtgcaaaaa agccggaggt gcttgaggag 1305781 tcgatagaag ccattcactc agaagcggtg catatgaaaa aactgaccaa tcagcttttg 1305841 gcgctggcca aaagccatca aggactcgag gttgatctga aaacaatcga tctgattaaa 1305901 gcggcgcgcg cggttatgca aacgctccag tccgtttatc agcgtgacat attgcttgaa 1305961 acagataaag agagcctgct tgtaaaggca gatgaagaac gcatcaagca gctgttgacc 1306021 attttgcttg ataatgcaat aaagtatagt gaaaagccta ttgagatgtc agccggaacg 1306081 aggaatggac ggccatttct atcagtgagg gatgaaggca tcggaatacc tgaggagcat 1306141 atcccgcatt tgttcgaacg gttctaccgg gcagatgagg cacgaaacag aaaaacaggc 1306201 ggaacaggtt taggcctttc cattgccaag caaatcgctg atgagcatgg cattgagctg 1306261 tctgtcaaaa gcaagccggg acaaggaaca gctgtcacca tgcaattcag cgaacagaat 1306321 gggggaggcc gatgactaaa acaataaaaa cagtatcttt tgctgcagca gccattttag 1306381 ttgtcatcat ctgtacgttt ctcatcattc ggcaaaccca tgagaacgta ttgtcaaagg 1306441 agactgtcgt aaaaaaagtc gaagcctctt atgaaggcaa ggtcacgaaa gcaacacaat 1306501 caaaggataa aaaaacatat gatataaccc ttgaaaatcc aaagggaact tactttgtaa 1306561 aagcagacgc aatatcggct gacattcttt caatgaatag agtaaaagca gtgaatccat 1306621 ctgccatgac agaaaaagaa gccgagcatc tcgcgcttga gcgggtgccg ggaacggtca 1306681 aaaaacaaac acggcaaagt caagttgcca cttataccat acaaaaagaa gacgggaaaa 1306741 catacgaagt gaaggtagac atgcaggcaa aaacagtctt gtctgccgat caaatcagca 1306801 gcaaagatca acaaaaaacg ccgattacga aaaaagaagc caaaacaatt gcagagcgaa 1306861 aaacgggcgg aacagcggat gacgcagatc tcgaagaaag tgagggcact ctcatctttg 1306921 aagtagacgt tgatcttcct gataataagg aagcgacagt gaaaatcaat gcctacacag 1306981 gaaaggtagc taacattgtg tatgaagact gacggtttct catcaaattc tcatcttgct 1307041 ctcgttttcc tttcatgttg agtatgtaaa ctgtactcat acaaaacaaa ggagggctca 1307101 caaatgctca agaaaaaatg gatggtcggt cttttagcag ggtgcctagc ggccggagga 1307161 ttcagctaca acgcgtttgc cacagaaaac aatgaaaaca gacaggcttc ttctaagacg 1307221 gatgcactca ctgaacaaga agcagaagca attgctaaaa cagttgttga cggcacagta 1307281 gaagacattg acagagacct ttacaacggc aaagaagtct atgaagtgga gattgaaaaa 1307341 gaaggtgaag actacgacgt ttatgtagat attcatacaa aacaagcgct taatgacccg 1307401 ttaaaggaga aagcagaaca agtcgccata accaaagaag aagctgaaga aattgcttta 1307461 aagcaaacag gtggaaccgt aacagaaagt aagcttgacg aagatgacgg tgcttacatc 1307521 tatgaaatgg aaatccaaac gaagcaagga actgagacag aatttgaaat ttccgcaaaa 1307581 gatggacgca ttatcaaaca ggagatagat gactaatcaa aacccccgct gcagcggggg 1307641 tttttcatga taagaaacct tcttttggac aatctaagta gaaaaggagg cgaaacgcat 1307701 ggaaaagaaa gaggagcaat acatcaatca ggctgaatat gtccctcatc cgacgaagga 1307761 aggagagtat gccttatttc ttcatgaaac gtatcatttg ctttctgaag atgacgagac 1307821 acaaacaaca gaataagggc ttaggccctt gttttgttcc gtaattgtga tgtaagcgca 1307881 tttattactt ttttgagttg acatagcttg tttttttctg taatctcagt gtgtcaattc 1307941 aattaggaac ttcgttaggt gaggctcctg tatggagata cgctgctgcc caaaaatgtc 1308001 caaagacgcc aatgggtcaa cagaaatcat cgacataagg tgatttttaa tgcagctgga 1308061 tgcttgtcct atgccataca gtgctaaagc tctacgattg aaggcgcccg cacgcttttt 1308121 ttgccgtgct tctttcacct tcaatcccga aggctttttt tatgccttta aaacgaaacc 1308181 aatcaaagga ggtgcggagt atggattctc cccattcgag tcaatctgaa gaagtaccca 1308241 tatactatga cagcaagaca attgattaca cgatgaggag acgaactgcc gcaccttctg 1308301 gcgaggccgg cacgtctccg tagaggaggt acgagtcccg atggttcaaa acatgaccta 1308361 tgacgaactc attttacgca tcattatttt actgcgagac gggaaaatca gggattttag 1308421 aagtgttatt gatgagcttc agccctatga catggcattt atttttaaag aaatgccgga 1308481 aaaacatcgc gcccgctatt tatcttattt aactgtagac gatatcactg atatgatcgg 1308541 ggagctggaa cgcgaatttc agcttgtcgt cttaaataaa gtcggaaaaa caaaagcaac 1308601 actggcgatg aacaaaatgg acaacgatga cctcgctcaa ttgcttgaag aaatggacga 1308661 agaactgaag gaacagcttt tatccagcat ggaagcgtca gaatcaaaag ctgtacagct 1308721 cttgatgaat tacccggctg attcagcggg acgcatgatg acaaaccggt atgtgtggat 1308781 ccctcagcat tacacggtaa aagacgcggt cgtcaaactg aaaagcttcg ctgaaatagc 1308841 tgaatcgatc aactacttat atgttattaa tgaaagcaaa cagctggttg gggttctttc 1308901 ctaccgcgat ttgattctgg gtgaacctga agaaaaggtg caggatttaa tgtttacccg 1308961 cgtcatatca gcagatgctc ttcaggacca ggaagaagtt gcccgcctga tagaacgtta 1309021 cgattttttg gcaataccgg ttgtagaaga aaacaacgtg cttgtcggca ttgtgacggt 1309081 tgatgatatt atcgacgttg ttattcggga agctgatgag gattacgaaa aatttgccgc 1309141 ttccggtaaa gacatcacct ttgacacaaa agcttacgtg gcggcatacc ggcgtctgcc 1309201 atggctgatt ttactcttat ttatcggact gatttcagga agcattatca gctattttga 1309261 agacgcgctg aagcaggttg tcgcgcttgc gtttttcatg ccgatggtgt cagggatgac 1309321 aggaaatacg ggaacacaat ctcttgcggt tgtcatcaga ggtttgtcta aagaagaaat 1309381 gaacaaaaaa acgattgtgc gcctgatctt ccgggagttc agaacaagca tttttatcgg 1309441 agcggtttgt tctgtgctga ttgcgattgt ttctatcata tggcagggga atgcgctttt 1309501 gggatttgtt gtcgcctctt cactgttctt aaccttaatc atcggcacga tgtcaggaac 1309561 gattatccct attattttgc acaaactgaa agtagacccg gcgattgctt ctggaccgct 1309621 gattacaacg ttaaacgata ttttatcttt attaatctac tttggcattg ccactgcatt 1309681 cattcactca ttataaacgt aaaaagtccg tctcaactgc gagccggact tttattattt 1309741 aacggttttt gtaccgaaag tgagcattaa gctgcccctc cagcattttt ttccgcactt 1309801 gcggatcgtt ttttaacatc tgttcttttt tgcgcatatc ctttaaaatc tctgccgtct 1309861 gtacgccgtc ttcacgctta ttggcgatat ccatcagccg ctccacatcg gcaaaggagt 1309921 attttcttgt cccccttgaa gaacgctgcg ggtaaatgag ctttcgttcc tcataatacc 1309981 tgatctgtct tacggacaat cctgtcaatt cactcacaat tccgattgaa atcacttttt 1310041 tgtctttata agaatgatct tctgtggtca tttttccacc cctggatgtc ttttgataat 1310101 agtatataaa aaacaaagag aaaaaacctg acgcttgtca tattttctaa catcaaatag 1310161 aagatttttg aaaaaatacg gaagaaaaat taacaagaat aatgcgtaac acccaagcgc 1310221 gttttatcct ttatgtaacg aatcaaacga ggaggaagga taatcatgga ggaagaaaaa 1310281 gcagtctcac tggcaaaaga aattatagag ttggatatca agcgtgatga aatgctggag 1310341 acgtttatgc agcttgccgg agaacaggct tttcaattat taagatcggt tcaaaacgga 1310401 caataccgaa aatcttcgta aacataaatt ctttacatta gattcatacc acgttcattt 1310461 aaaaagagta tcttttgtat aggatacctc aaaatgaagg aggacgctat gagtaattta 1310521 ttgaaatccg ctttagaaaa agaacgacgc cattattctg aaaaactcta tcagataggg 1310581 gtttataata aagaggtcat gaacaaaatg acgatttctg agcttcggaa agaatacgct 1310641 tatttctttc gaagcattac aaatcataaa aattatcctt atacaagata atgtataagg 1310701 atttttttgc ttttagaagg aatttctcga attatagcga atacgtatag taagggactg 1310761 aactcttatt atatgtaagg gttttcatta tttttttata aaaatcctat atacgaggta 1310821 gatatgatga gattatcgtt taacgaagaa gaagttgagc gtgcgatgaa tttgtacaga 1310881 gtttttgcaa gggctttcaa aagtgtgtcc gaacatagta tccgtgatag caaagagcac 1310941 ggttttaatc ccactgaatt tgctgtactg gaactcctgt acacaagagg cccgcaaaaa 1311001 ttacagcaaa ttgggtcgag acttctgctt gtaagcggaa acgtcacata tgttattgac 1311061 aaactagaaa gaaacgggtt tttagtaagg gagcaggacc cgaaagataa acgctctgtt 1311121 tacgcacatt taactgacaa gggaaatgag tatttggata aaatttatcc gattcatgca 1311181 ctgcgtattg cgagagcgtt ttcaggtctt tcgcctgatg aacaggacca gctgatcgtc 1311241 ctgctcaaga aagcaggcat acacagccag catttgctgt ttcgttaact attctacact 1311301 ctctatttca ggagagtgtt tttttgtttc catatgattc tttttaaaac atctttaatc 1311361 ttcctatcag acatttcgcc aaggtatcca ttgacgtgtt ttttatactc cttcatctgt 1311421 tcgttcgatt gaaaaaatgc cgcgatatac tcttctgctt tctgcatgtc ccagtttctc 1311481 atatctgtga cgagtttcct ttcatgtaga aggtttaaat tcatttcctc ctgtcccggc 1311541 agtgcatgat aaataaatac cggaagccgt ttctgtaagc attcactgat ggtcacgcct 1311601 ccgggtttag tcatgatgcc tgtcgcctgt tcgtacaaac ggttcatctc tgctttgctg 1311661 tgaaggtaag gaatcgcctc aatcaagggg tggtgtaaac ttttgacata ggagtagagc 1311721 ttttcgtttc tgccgcataa tattttgtat aagatctttc cgcctggcga cagttcctgc 1311781 acccatttta aaatcccacc gacccccata ctgccccctg tgatgatgat ggtatatggc 1311841 gggtggtgct gcaaggtatc tgctgattcc atttcaaaat tttggtgaac tggaatgccg 1311901 gtcaagtata tgttgttctg atcgataccc tctgatatta gctgcttctt tacttccgtg 1311961 ctcggaacaa aatggtaatc aatgttcttc cgtccccata attgattcac gaaaaaatca 1312021 gtgtatacat tcacaaccgt cagattcgga tattcaggct ttagtcggtt cagcagataa 1312081 gaaggcagcg catgtgtgca gaaggcgata tcaggctgtt tttcttggag gatgtgcctc 1312141 atttgctgtg tgaacagcca ttcgtacatg aaatagcgtt tgtcatgctg aaattctccg 1312201 caggcgagga gcctgtaaat gccgctgtac gttttcggga aatattgaat ccattttaaa 1312261 taagccacgg aggacaattt ttctaaccgc ctatacgaat gtgaaaagat atcaatcttt 1312321 tcagctgcca gcccttgaga ctctaattca gcctgcaatg catcagccac atgatgatgg 1312381 ccggtggaaa tgcttaaaaa aggaaaaatg agaatgtttt tcatgacagt cctcctaaaa 1312441 aaatatggca actatatttt gaggagaacg ttcacaaaat ataagggtgt ttttgatcat 1312501 aaggaaggtg aaaagatgaa aacttgtttc ctttccatat ggagagtggt tgatccgatt 1312561 tatttctttt tttcaaggct aagcttgatt gacaacgatc aaaaaagcgt ttttcgagtc 1312621 aggctgacga agtacaaagg acatcatgtc gtgcttagcg acggaacgca tataagaaaa 1312681 aatgatgtgc tcgttaaaat ccacctgcat aacataaagc tgatcaggga gctgcaaagc 1312741 attgagagcg cagtcagaaa gggaatcatt atttatcaga aagtatatca atcgatgccg 1312801 cttcttcttg actatatcaa caatcataaa aaaagcgaga aaatcaaagg aatcattggg 1312861 attacaatgc ttgacaaagg tgtggaaagg ctcggctttg atgtgatcac cccggtgaac 1312921 cctttttaca gatgctttaa aaaagtgtct catgtgccga ttttatattt gacttcaaag 1312981 cctgtgagct tgcggcattt accgaattca tcctatttgt ttatctcaaa agaaaagctg 1313041 cagaaaacct atcaaaaaaa agactgatgc ctcggtcagc acagtctttt ttgattaaat 1313101 ctgatgaaat gtcacttcag ggcggcttcc gacacggata tttacgccgg tttgtcccaa 1313161 gccctcgctg atataaaatg gtttatcgtg atgataatga aggcctttaa tcatgttcat 1313221 tcgcacgagc tttcccattt tcaccaaatg atacggtttt ggccagtgaa tttgcccgcc 1313281 gtgaaaatgc cctgacagca ggtaatcata atgaacatct ttcatatcca gaataatatt 1313341 tgggtcatgt gttaagacaa gatgatagcc attttccaga ctttgataag agccggtgat 1313401 attactccga ttcgtactgt aatcatcaat gccgataata ttgactggtc ctgcagccgt 1313461 ctcgattcga acatgttcat tttgcagcgt gatacagccg ttttcctcta aaactcgctt 1313521 caatctctga aagtcctctt ctttcaatac ataatcgtgg ttaccgaaca ccgcgtacat 1313581 tccatatgca ggctttagct tttgcaaggc gttcaagtaa cctgccagtt tcggaatatt 1313641 acgtttccga tcaagaaaat ccccggtaag agcaatgatg tccacaggct gatcttttgt 1313701 taaatgatac agctcctcag gtgagactga aatgttttcc aagtgaagat cagataaatg 1313761 aaggatattt aatttttttc tggctggaag gccgtctttt tggtcgattg aaatggtgtt 1313821 gactttcaca tcttttgtat tgcggttcgc tttatataga aatggcacaa atacgagtat 1313881 ggccaatgaa agtaagattg taaacaaaat atatcccctc ccttctatca gtatagtaag 1313941 tgatcaagcc ctatggatag cgggaattaa tgggtagaga caggttgaaa aacggattgt 1314001 catatgatga atgatttgga agggaaaagg gataataaat tttgacacat gaggcagaac 1314061 atgccgacgg agtcagaata acaaatggat gtgtaagcaa tgttacgatt gatgagacaa 1314121 caaaaaaaag aaacatatta tctctggatc gcattatttc ttcttttatt gtatgtatcc 1314181 ccgcttttta ttttaaagga agatgcccat atccgggtcc acgataattt agattccaac 1314241 atcgcttggt acaaggttct ggccgatagc ggagaaatcg tcggcaaggt tgacgctgcc 1314301 attccgcaaa tcattaacgg gctgccccgg gatgcctttg gcaccgagtg gagcggaatt 1314361 gtttggctcc atgctttctt ttcttccatg accgcctatg caataagcca gacggttaca 1314421 agagttgtcg ctttttttgg aatgtatgtg ctgctgaaga aacatataat cccggaacca 1314481 aaagcggctt tcatccgaat tggcgtatcg cttgcatttg ccttaacacc gttctggcct 1314541 tcgggaatgc tgagtacgct tgggtaccct ttggcactgt gggctttttt aaatatccga 1314601 aaaggggata tctcatggag agagtggctg acgctgggct tgctccctct atactcaagc 1314661 tttgttctag gcttcttctt tttcctggca gggatggcgt gtttttggct gtatgatgcc 1314721 attacaaaaa gaagatggaa tttgatgttc ttaggcagta ttgcatttat gacgagtatc 1314781 tatcttttcg ttgaatatcg gcttgtctat tcgatgctgt ttgagcacgc accgatgcat 1314841 cgtatcgaat ttatctcatc taggcatgac gtttggcatt ctcttcgact atccataaaa 1314901 aactttgtct atggccataa tcatgtgatg accgttcata ccgttgtcat ccttccgatc 1314961 ctgatggtcg tatttgctgc tctgctgttc aaacgaaatc ggacaaagcc agaaaatgtt 1315021 tatctgtttt tatgtgtgct taattacggg ttgtcattat ggtatgcgtt ttggttcaac 1315081 aaaatttggg ctgttccaaa gcagaaattt gcttttttag cagaatttaa ttttgcccgt 1315141 tttcattttc ttcggccgct tgttatatac gtgagctttg cgcttgcttt atatctcatt 1315201 tggcggatgg ggaaaggatg gaaatggctt gtgtacgccg cagtcgctgc acagctgatg 1315261 gtgttggcgc cttttaatga agaatatacg tatggtgttc attacaacgc gccgacattc 1315321 agggagtttt atgcatcaga gcaattcaaa gagattaagg aatatatcgg acgtccgcaa 1315381 gattcgtata gggtggcgag catcggactg catccgtcta tcgcccaata taacgggttt 1315441 tatacgttag atacgtataa caatctgtat ccgctctcat ataaatatga atttagaaaa 1315501 atcatcgaaa aagagctgga aaaaaattct cggctgaaac aatactttga tgaatggggc 1315561 agccgctgct acctttttgt cgatgaactc ggtaaacgat atgatttcaa aaagaactcg 1315621 aagaaaacga tcaacaacct tcaattaaat acagatgtat ttaaaaaaat gggtggacgg 1315681 tacatttttt cttcagttcc gatcatgaat gctgaacaaa accatctcgc gctcgtaaag 1315741 acgtttgacc ataaagattc cgcctggcgc atttatttat atgaaacaag ataaggagga 1315801 tatcgattga aacagtcaca gccagtatta accatcgtcg tcccgtgttt caatgaagag 1315861 gaagtgtttc aagaaacaag ccatcagctg acagaggttg tagatgattt aattgaagaa 1315921 aaattaattg ctgaagacag taaaattctg tttgtcgatg atggcagcaa agaccgcact 1315981 tgggctttga ttgctatgga gagcataaga aacaagaagg ttaccggctt aaaattagcc 1316041 tgcaatgtcg gccaccaaaa agcgctttta gccggattgc ataaagcgaa gaataggtca 1316101 gactgcgtca tttcgatcga tgctgatctt caggacgaca tctctgtgat ccgggatttt 1316161 atgctgaaat atcatgaggg ctgcgagatc gtttacggtg tacgccggag cagaaaaacc 1316221 gatacctttt tcaagcgcac gaccgcgtta gggttttatc gtctcatgaa taaacttggg 1316281 attaaattaa tttataatca tgctgatttt cgtttaatga ataaaaggtc ccttgaagag 1316341 cttgagcgtt atccggaagc gaatctgttt ttaagaggta ttgtccccat gatcggcttt 1316401 aaatcggccg aagttttgta tgaccgcaag gaacgctttg ccggcaaaac gaaatatccg 1316461 ctgaaaaaga tgctatcctt cgcttttaac gggattactt cattcagtgt cgcaccaatt 1316521 cgattcttta cgcttttagg gtttgttttg tttttcctca gcgctgtggc agggattggc 1316581 gcgtttattc aaaagctgct cggccatacg aatgcaggct gggcgtctct tatcatatcc 1316641 atttggtttt tgggcgggct gcaattgatg ggaattggaa tcatcggaga gtatattgga 1316701 acgatttttt ctgaagtgaa aagacggccg aaatacgcga ttgatattga tttgtataat 1316761 gaacagctga gcccgcttca gcgccaggaa aaagagcggt tagaaaaaaa gtacagttaa 1316821 acacggaaag agctgacttc attagtcagc tctttttctt caactgatgc aatatagcgc 1316881 taagcggttc gtcttgcggg ttgcggtaaa aatcaaaaaa tgggcagccc tgcttcttaa 1316941 ttcgatcgat gaccgtatca attgtaaaca gagcgggtgt taaagatgat tgcacctcat 1317001 gccagtagag cggggctgca acagtcccaa gctcatttcc tctcgttgaa tagggacaga 1317061 taatcgtttt tccttctgca tgctgcaaat aatcaagata caatttgcag tgtctgtttt 1317121 taatcaagcg ttcagtggta aagagctcgg gaaatgcatt ggtgcagtac tctgcgatca 1317181 gctgcgtaaa ttggcgtgtt tcttcatacg taaatgcctc gggagacaag ggaatataaa 1317241 gctggatgcc tttgttgccg gacagcttcg ggtacgatgt gatgccaaag gaatccaaca 1317301 gccgcttcag ttcatttgcg gcctgcacgg ccataagaaa gtcatctcgc gaaggcgggt 1317361 ctaaatcaat gacaatctca gccggacgcc tgcttttaat ggtttgaaaa ggaacgtgaa 1317421 actccaaagc aagctggttg caaagccata gcaatgtaga catatcctca cagacaatat 1317481 gttcatggct tccatcatag aaagactgaa caaaatccgg cgcatagtcc ggcttgtttt 1317541 tttggaaaaa tgattcgctc ctagatccat gcggatagcg gatgacggtg acagcccggt 1317601 ttttcagaaa tgggagcagg tagtcactga cttcaatcat atactgaata aaatcttctt 1317661 ttgttttttt attcttttca aatatgattt tatccaggct tgtgaactgg agctttgggt 1317721 gaaccggttt ggagtgtcgt atgacttgcg catacgtgca ttcggtccag tccatttgga 1317781 attcgaaacc gataaacgat acctctctta atgtgccttg gagaattgtt aagtattgaa 1317841 cagctgcaca aatcgaaggt tcaagcgtaa attcgcctga gggtgtttga tgtccgtgct 1317901 gttccataat ctcgcgtata gcgctttttt cctcatcacg cattccgtgc gagacagagg 1317961 caatcggtgt cattattccg ttttttaaca ccgataccgt cagaaacccg ttgttagggt 1318021 tgaaccctgt tatgcaaaca taagcttgtt taaagttttt atatttgagc caatcggacg 1318081 accgcttctt ttcaagccat ttgctgtttg ttttcttcgc tacaattcct tctccgtcat 1318141 attttattac catctcccag agttgatcaa aatgatcata acagggaatg gattgaatgg 1318201 tttcttttgc gtaaggatct ggagatgcag gaagctttgc tgcggatatg agttcacgca 1318261 gcgatttttt gcggtccaaa tacgaaagaa gcgttacatc ttctccgctt cgctctaaca 1318321 aatcaaaggc gagaaagcag cacggccgcg cgtttgccga ttcctgaatc ttgtctggcc 1318381 ttttcaaacg cccccgcact tgaaggtgtt caaaatctgc acgacaggga ttcaccaaac 1318441 atacgatttc accgtcaagt gtcagcggaa gctctttttc taggtgctga aaggcagttt 1318501 tggcgaattg tgtgatttca gggaaggtgc tgctgagctc cacaccattt ctgctggtta 1318561 aggtcacacc tgaagaatgg atgcggagaa tacagcggta cccatcatat tttacttcgt 1318621 aacgccattc tgctccgatt ggcggtgacg aagttaagac cggctgcatg gtaaacgcca 1318681 tgcgctatga tgtgccggag gctttttttc tagttgtttt ttgtttttta tctccggctc 1318741 ctttcggttc agcggcttgt gcaggtgcgg cagccggtgt ctcccggttc ggccttctgg 1318801 ttctgtcgat gctggcttgc agagcgctta ccaggtcaat gacatcttca cgaggtggcg 1318861 ctttatcagg agtgacagcc gtttctttat tttctagctt gtcgttgact ctttgcagca 1318921 gcgcctgtcg gtacgtgtct tcatatttct caggctcaaa cttagcagtc agttcatcta 1318981 ttaatgtgat agcagtttgc agttccttat cgtttacatt cgattgatca ggtacacctg 1319041 ggacttgagc ggcgcttctg acctcatcgg gataatggat agactccatg acgatacaat 1319101 tttcataaac gcggagaatc gccagctgct gctttgacct gattgtcata ttggcgatac 1319161 cgatctttcc ggttgagcgc agcgcctcac gcagcagggt ataggccttc gtcccattat 1319221 ccccggggcc gacaaagtag gagcggttaa aataaatcgg atcaatttcc tgaagctgaa 1319281 caaagtcaac aatctcaact gctttctcct catgctcctg ttttaagctt tttaaatctt 1319341 cgtctgtcag cactacatat tttcctttta catattcata tcccttcaca atttcatcag 1319401 gactaagagt tttttcgcaa tttgtgcaaa ctttctcgta tttgattggt gcgtgatcct 1319461 ctttatggag gctgcgcagt ttaatatctt tatcttctgt ggccgcatat agcttgatgg 1319521 ggatgtttac taatccgaag ctgatcgatc ccttccacat tgtatgcata tcgataaacc 1319581 cctttttttc tttagtgtga agagaaggag tacgattcat gtgtagtaac ttatgggtga 1319641 aaaaaagccg gcgctgttat tgcgacggct gttcaataat gaattgttcg aattgttccg 1319701 gaggtattgg cctgctgaaa aagaagccct gcaaatggtc gcagcctttt tcaaaaagaa 1319761 gctgcttttg agctgcattt tccacacctt cggcaatcac ctgcaaagac agctgatgcc 1319821 ccatggcaat aatagctccg gtaatttgct ctgatttagg atgggtctga atatcgtcaa 1319881 taaatgattt gtcaatcttc agcctgtgaa tcgggaagtc cttcaaatag ctaagagagc 1319941 tgtgaccagt accgaaatcg tcaatactga ttctgattcc taattctgtt agggatgaca 1320001 aaaccttttt ggagtgattg agattgtcca ttgtcatgct ttccgtcacc tccacttcaa 1320061 gaagctgcgg aggaagctgg tacttattaa gcgtatcctt gatgagggga atcagatctt 1320121 tagattgaaa ctgtctggcg gaaatattaa tggcgacaga aagatcatag cctttgtcat 1320181 gccaaatcct tgcctgcttg catgcttcat ctataatcca ctttccgata tcaataataa 1320241 gtcccgtttc ttctgcaaca ccgatgaatt ctccgggcgg acgcagttgc ccgtctggtg 1320301 tcacaaggcg tatcagtgct tctgctcctg tcattttttg ttttttcaca ctgaattgcg 1320361 gctgataatg caagacaaat ctatcgtttt cgattgcttc tctgagtacc atctcttggt 1320421 taagcttaac ggtttctttg ttgccgattg aaaaagaata gtatctgtat ttgcttttgt 1320481 ttcgttcttt agccgcatac atcgccatat cagccttttt catcaattca aggccatccg 1320541 tcccgtcttt tggagatatc gcaatcccga tactgacaga tgtgacaagg gtgtgatctt 1320601 gaattttgaa aggttttttg aatttttgga taatttttct tgctaaaaca tctgcttcgc 1320661 ctgttcctgt attggcgtct gttaatataa taataaattc atcaccgcca agacgggcga 1320721 taaatccgtt atcagggact acagatgaca ggcgtttagc tgcaaactga agcaattgat 1320781 caccgacatt atgccctaat gcatcgttaa tcactttaaa ccggtttaag tcaagaaaga 1320841 atacaacagt gttataatgc aaggaatgct cgcgattcag cacctttgtt agatgagaga 1320901 tggcatgcct tctgttaggt aagtctgtaa gcgaatcata atgagccatt ctatggattt 1320961 ctttttctgc tttgtactgc ttcgtcatgt ctttacaaat gacataaatg ctgtctagtt 1321021 cctgattgac ctcaacaggt ataagcgtaa tatttaagtg aaactggcct ttttcagtga 1321081 taagatcgct atcgctgttc atcgcttgtt tatctttttt aacttgctca aaaaggcgct 1321141 taaccttcag tgatgtgtaa ttcctccagt catgcatgct gaagccaaat ttgctgatca 1321201 tttcctcacc agcgtgattg gaagatatta tgtctccttc taatgataaa ataaaaattg 1321261 catcaatatt gtggacgatt aaagactgaa atcgctgttc gttatccttt atgcgttcgc 1321321 tctgtttaat aaactttcga tctgcatggg aactgaataa caataacgtt tggatacaaa 1321381 aaataattaa agtaacaaaa attgaccaat gaaacgtttg cacctccata tggcttccgg 1321441 gcggagccat gtccttatgg aaagttgccg caagcatccc tgtgtagtgc atgcccgaaa 1321501 tcccaatgcc cattacaatt gaactgacgc ctttatagaa tataagatgc tcagaatgtt 1321561 tttttacggc caagtcaaag aatattttta acgagacgaa agaggctgca atcgcaatga 1321621 taattgaaac tgtaaataaa ataggttcgt aaataatcat tacccgggaa atggcagaca 1321681 ttccgatata gtgcatagaa gcaatagatg cgccaagcac aactgatccg gtaagcagtc 1321741 tgtaatatgt aagaatgtgc cggctgacaa aatataatga cacaaatgat cccgaaacag 1321801 atgcgccaat ggctgccatt aaaggcatga attcatattc catcggcatt tccatatgga 1321861 cggccatcat ccctacaaaa tgcattgacc aaataccgaa tcccataata agtgagccgc 1321921 cgatcagcca aattttactt tttaagcctg tattgatggt gactttcctt gaaagttcaa 1321981 gggaaatata cgaggcggta caggcaatta gaatagataa acatatgaga gtcgtattat 1322041 atgtaacgtg tatttccaaa tggagattcc ccccgtatcg tgtgttccag tcttgttgac 1322101 tctctttatt atcggctgct taaccgcaga gtttcagcct tcaaaacgat agaaatacga 1322161 gggagatcta tttttagttc aactgaccgt gaaaaatgtg ttaaaatcat cttgatgttt 1322221 tccgaaaaga gaaaaatgta tgatacataa acatgaaaca agggagttgg tggctatcga 1322281 agagctggtt atgtcatgga ttgaagcatt taaaagctta tcttattttg gaatatttct 1322341 agcgctcagc attgagttta ttccggccga agtcgtcttg ccgcttgcgg gctattgggt 1322401 atctaaaggc gatatgacac ttgctggcgt tgttttggca ggatcgcttg gaggagtggc 1322461 cggtccgctt acgctgtatt ggataggccg gtacggagga aggccgtttc ttgaacgttt 1322521 tgggaagtat ctctttatta aacctgaagc gcttgataag tcagataatt ttttcaaaaa 1322581 acatgggggc tttgtcgcct tcagcggccg tttcttgcct ggtatcagga cattgatttc 1322641 cataccgtgc ggaattgcaa aaatgaatgt ttgggtgttt tcgctttata cattcattgc 1322701 tatgcttccg attacatttg tatatgttta tctcggtgtg aagctcggtg aaaattggaa 1322761 ggcagtcggc tctattcttg atcaatatat gcttccgatc gggatagcga ttttggcgct 1322821 gttcctgctc tacttactga tgaaaaagag gaagaaacgc acgcactccg aacaattatc 1322881 tgtatttttg aaaaataaac gttgacaaat cactgcgctg cgcatattat tgacgtataa 1322941 aatcatattt cttgaaatcc caaaggggag tagcgtccgg aatgtattcc ggaaacaaag 1323001 tcgtcatttc atggattgta tccatcggct ttgttggcat gcctgaattc atgtctagca 1323061 agacctttgc cttatgtcgg caaaggtctt ttttgcatgg tccggccggc ataagatcgg 1323121 atgaagagaa agaaaacaac ttttttggga gggtatcatt tatggatgca gcattattat 1323181 tagagtatgg ttgggttctt ctcgtcttga tcgggctgga agggatttta gccgccgata 1323241 acgcgctggt tatggcggta atggtaaaac atttgccgga ggaaaaaaga aaaaaagcgt 1323301 tattttatgg attggcaggg gcttttgttc tgcgatttgg ctctttattt gcaatttctt 1323361 tcttggtcaa cgtatggcag gttcaagcga ttggcgcgat ctatttgctg tatatctcag 1323421 caagccactt attgaaaaga tatgtattta agaaagaaga cacacataaa gagacgaagc 1323481 aaagcggttt ttggccgact gttttaaaag ttgaactggc agatatcgcg tttgctgttg 1323541 attccatctt agcagcagta gcgctggcgg ttacacttcc tgggacatca ctcccgaaga 1323601 tcggcggact tgacggagga caatttctcg tcattttggc cggcggtatc atcggactgg 1323661 tgatcatgcg gtttgcggct tccatgtttg tgaagttatt aaaggaacgt ccaagcctag 1323721 aaacagcagc ctttgtgatt gtcggctggg tcggagtgaa gcttgcttta tatacgcttg 1323781 cccatcgcga catagcggtt gtttctgagc actttatcca ttctggaaca tggaagctga 1323841 tattctgggg tgtcttagca gcaatcgcgg tttgcggctg gtttatgtca ggtgggaaaa 1323901 aacagccgga gggtgcacaa aacgaacaaa aaaacagcac ccgtgaacgg gcgtaatctg 1323961 aaagactctg cttaaaagca gagtcttttt gtgtttgaag cgttttcata agcgaaataa 1324021 aataacattt ttataacatc tttgttacaa aaaacacgca taaaaccccc ttaattcttt 1324081 agaaaggcac gaaatcatgt atagaacgtc agaatggttt gtcataattg agacattgga 1324141 aatcaatatt tctttttctc ctttgcgaat ccctatcaaa ttagctatca ttaatgagta 1324201 gttataggga ggaactgagg tgaaaccagt gcttagcctt ttgtttaaat tgggaaaaaa 1324261 gaagcaaaca cttgaaaaag ctgttgagag tatacaaaaa ggcaataaag atctgcaaaa 1324321 tgaattaata cagcaatata agccatttat cgcaaagacg gtttcatccg tttgtaaacg 1324381 atatatagat gaaaaagacg atgagttcag tattggactg atcgcgttta atgaagctat 1324441 agaaaaatat tcacctgaaa aaggaaattc tctgctcgca tttgctgagc ttattataaa 1324501 aagaaaagtc attgattaca ttagaaaaga agccagaagc gcacaaaata taaatatcga 1324561 tttacaggaa ggagacgatc aggagtcatc acaaagcctg attgaagccg agctttccat 1324621 tgatgaatac cgccgtcaga ttgaacagga gcagaggcgg gaggaaatcc tctattttca 1324681 aaagcagctc aaggattatg gtttatcgtt taaagaactg cttgaaaatt ctccaaaaca 1324741 cacggatgca aggcaaaacg ccataaaggt ggcaatgacg cttgttgaac atgaagaatt 1324801 ggccgctatc ctgtatacaa agaagcagct tccggtcaaa cagcttgaac agcttgtctc 1324861 tgtaagccga aaaacgattg agagaaacag aaaatatatt attgcgatgt gtattatcat 1324921 tacgggtgat tatatttatt taaaagatta tcttaaaggg gtgctgcact catgagaaga 1324981 gggattatag tagagaaaaa taaaaaattc gtcacgttgc tgacccctga cggacaattt 1325041 ttaaaagcca aaaatgatcg acacagctat gaaatcggag aagaaatcat gcttccgagt 1325101 gaaacacgca tgggcagaag ggccagcttt tttgattttt ttaaactgcg ccctttcaaa 1325161 atggggattt ttacgatgac tgctattatg ctctttattt ttatagttct ccccgttttt 1325221 tctaataata aggcctatgc gtatatgaca atcgatatca atccaagcgt cgaaatggcg 1325281 ttaaacagcg attatgaagt gattgaactg acgcctctaa acgatgaggg acagaaagtc 1325341 gtgaatgata tagatgattg ggagaagact gattttaaaa aggtgattga cgatattata 1325401 accgactgca gtgaacacgg gtatgtaaaa aaatcgaaag aaatattgat ttccactgtt 1325461 tatgaaaaca cagaagacaa tacatataaa aaggctgtga aaaaacagct gaatgatgtg 1325521 actgaaaaat ataaaacgac ataccgcatg gaatctctcg agtcagatat gcaaacgagg 1325581 gaaaaagcga agaaagaagg cgtctcaaca ggcagctaca tcaaatcaaa tgaaaagaat 1325641 gacaataaag atataaaaga tgactccagc aaaccatccg gggaagagga tcaaaagagt 1325701 gatgaaaatg aggatgaaaa caccgatcaa actgacaccc aggacagcaa gcaaggagat 1325761 aatgaacagc tgaatgatgc ggattccgga gaccagaaag aagagaaagc ggatgaccag 1325821 attgatgata gtgacaaaga taaaaaaata aaggaatcag atgaaaacac aaataccgaa 1325881 aaagatgggg accatgagca aaccccaata caagatcctc aagataaagg aaatgaaaat 1325941 aacggcgctg acaagggcca aagccaatat cacagggact ggaacaatgg tgaacaaggc 1326001 aagaaccgtt cttcgtccag aagggataac gcttcagacc gacgtaatcc aaacggctac 1326061 agcagtgata atcattcagc taaaaatgaa gattcgccga gtgcccccgg cgaataaaga 1326121 cctgaattta tttagttgtg ccatttaatt gtgattgtgc ttgctgtacc agccgctttg 1326181 tcatttctcc gcctacagag ccgttagcgc gtgcgactgt atcagaacca aggttcacac 1326241 cgaattcttg agccacttcg agtttaaatt ggtctagtgc ctgctccacc cctggaacaa 1326301 cgagtttatt tctgctcgcc atctttttca tctccttttt cgataaagaa attcttaacg 1326361 cgtatttagt ttgaaatata cggggtttat ttatgctggc aattgttgtg gagaaaaata 1326421 aaaccccggc ctctgagccg gggtggcgca gactatagaa tgtctgctgt cattttatgt 1326481 gcggttgcct gaatatggaa tgtcaaaatg gagaggactg taatggcgat aatctgtctg 1326541 attttaagcc attggctgtc attcagttct tcaaaacggt gacggagacg ctctgtctcc 1326601 tgttcggcga tctcctgcag atttgattct ttcatagaag gagtatcttg gtgatggatg 1326661 gcatcaagca catatgcgca gctttcataa taagcaatcg ggctgatgac atcatcagat 1326721 ctgtctgaga ttgtgttaaa ggccactttt aaaatagccc gtatgtgttc aaagtcataa 1326781 atggatttta aatcacgtac aattaaaaga ataactgcct gttcaattga gtattttttg 1326841 cccagctcag ggtgtccgat cagatctttg atatcacgct ttacccagtt ttgaatcgcg 1326901 gttgacttta acgaagtcag ctcgcataag ttgccaagct ctacgatttc atttgtagac 1326961 agaccgtatt cttttttctg tttttttcgt tcgtatcttg taagaaattc aggaatttct 1327021 agatgattgg ctgctttttc tgctgacatg ttcgctgatt ggacgagaat gtcgagcggg 1327081 ctatgttctc cttgtccttt tagggaatag agcagccgca ccatatcggt tcgagagagt 1327141 ttaaaaatgt tcattgttca cctctttaaa caatttgacg cggatatagg tctatgtata 1327201 agttcaaaat tcaagcgtca gcaaattaca ttaacatcat acgtcgaatt ccttgcattt 1327261 tcaaatggat gttttataat ttaaatatac gggttctttt gaacttaaaa taacggaggt 1327321 tgttatggcg aaaagaattt ttctgtttat tctaacgaat attttggtgc ttacaacaat 1327381 cgggatcgtt ttgtctgttt taagctctgt tacaggagtc gggacgtact ttacagctga 1327441 tggcggtatc gatccaatgg cgcttcttgt gttcagttta gtcgttggat ttgtcggttc 1327501 ctttacgtct cttgcgatat ccagatggat ggcaaagacg atgatgggcg tcagagtgct 1327561 gaatccgaaa aaacactcgc tcagctatga ggaacagcaa ttggttgatc gtgttcacag 1327621 attaagccgc tctgccggtt taacgaaaat gccggaagtc gggatttacc gttcacctga 1327681 agtaaacgcg tttgcgactg gaccgtcaaa acgccgttca cttgtcgcag tatcgtcagg 1327741 gctgctggag cagatggatg acgcagcagt tgaaggtgtg cttgcccacg aggtcgcgca 1327801 tatcacaaat ggtgatatgg taacaatgac gcttttacaa ggtatcgtta atacctttgt 1327861 cgtcttttta tcgcgtatcg ccgcttggat agcaagccgt tttgtcaaag aagatctagc 1327921 gccgatcgtt cattttattg caatgattat ttttcagatt gtcttttcga tacttggcag 1327981 cctggttgtg tttgcgtatt cacgccatcg tgaattccat gctgacaggg gaggagcgga 1328041 tcttgccggc aaggacaaga tgattcatgc gctgcggacg cttaaaagct attcttcccg 1328101 gattttggaa gacgatcaga cagctgtcca aacgttaaag attaatggca agaagcgctc 1328161 ttcacttttc tctactcatc ctgatttaga tgagcgaatc agacggctgg aagctaaata 1328221 atacaaacac attgttcctc tgagagaatt ctcagaggtt ttttatttta tccattgact 1328281 aaaatcataa aaaaataagc aagttaagaa aatgtttcgt aaaagccttt aaaaatggac 1328341 ctaatatctt tagaataatt accgtactta aaaagagagg cagaaggatt ttacatgaga 1328401 ttaaagtttg gaaaattgat acaggccttg tcaccggccc agctgatcgc attatattat 1328461 tttcttgcag ttactgtggc cgttatattg ctgagtttgc cggcggccca taaaccgggg 1328521 gcggattgga cgtttattga tgcgcttttt acagctgtca gttcagtcag tgtaacgggg 1328581 ctgacagttg ttgatacagc tgatacattc agcacaatag ggatttttat attagcattt 1328641 gttctgcaat ttggcggaat cggaattatg acgctcggaa cgttcatttg gctgatcatg 1328701 ggaaaacgaa tcgggctgaa agaacggaag ctgattatgg ttgatcaaaa ccaatcccag 1328761 ttttcaggaa ttgtcaatct gatgaagcag gtactgtttc tgatcttgtg gattgaattt 1328821 tttggcgggc tgatactcgg cacatatttc ttaacctact atgactccta tcaggaagcc 1328881 tatttacacg gattttttgc cagtatcagt gcaacgacaa acggcggatt tgatattacc 1328941 ggtaattcga tgattccatt tcgccacgat tactttgtgc agtttattac aatgctttta 1329001 attatatttg gagcgattgg atttcccgtg cttgttgaag taaaggattt cctgttttca 1329061 aagcatcggc gttatccatt tacgcttttt acaaagatca cgacgattac gttcggctca 1329121 cttgtcttgt ttggagccat tggcatcttt gccctggaag caaaccatgc gttcgcagga 1329181 aaatcatggc atgatatttt gtttttgtcc ctgtttcaat caacggcaac ccgaagcggg 1329241 gggctggcaa caatcgatat cagccaatta tcagattcca cactcttttt tatttgtgcg 1329301 ctgatgttta ttggagcgtc gccaagctca gtcgggggag gcataaggac aacgactttt 1329361 gctttgaacc ttcttgcgct gtttcatttt gcccgcggca ataaggccgt aaaggtattc 1329421 aaacgggagc ttcaccctgc tgacttgatg aagtcgcttg ttgtcacgat gatggcgatc 1329481 ctgctcgttt ttggcgcgac actcattctg accattacag aaaaacattc cctgctggag 1329541 cttttgtttg aagtgtgctc ggcattcggt acaaccggcc tatcgcttgg aattacggca 1329601 gatttgagca gtgttggaaa atgcgtcatt atgattgtca tgtttatcgg gcgaatcggc 1329661 atcttgacct tcctgtatct gatcggaaga aaggaaattg aagcgaatta tcactatccg 1329721 aaggaaagag tgattatcgg ataggcaaaa caccgcatat tttgcggtgt tttttgatta 1329781 ccaaaaaaaa gatgtgtgcc tcctgttcag ttggagaacc taactccgac aggtgcaatt 1329841 tacgctcctg catcttaaaa tgtctgaaaa ttggcgagga ggattcgtat gaagcgtaaa 1329901 gctgaagtga atgaagccat taaaaataac aatacaccta ccgagagcat ggaccccaat 1329961 tcatataaga cacaatatca tgacgacccc aattttagag gggcaaaccg caattccaaa 1330021 cagggccagc agggaggcat gtaattgtga agaaaaaccg tcatagcaga gacatgcaaa 1330081 atcataaaaa gcctatgaat aaaaaggtgc tggaggaaga attctcaagt gaactcgggg 1330141 attacaatgc cggaaagatc atcgaaacgc tggaagtcac caagcctgaa aagaaaaaag 1330201 aaaaaaacaa aaaacaacaa taaaaaagac ctcttaggcg gcgtcccgct taagaggtgc 1330261 tttttctatt ttaaataagc atttttgccc gttcctctga caaattgcaa taagcttgtc 1330321 atcctcagct caatgaatgg ctgagcgact gtcttaacaa agttgctgga gaggactgat 1330381 gtcagggctg ctgttaaaag caagaggatc actaagcttt gatagtcagt aagccaatcc 1330441 tcaagcccga cctgccgtaa tgtcttaata ataaacccgt gaagcagata cacgtaaaat 1330501 gtccgggttc cccatttggt aaagaaatac cgtttttgcg gaacgagcgc taaaaagctg 1330561 aaggttgccc caaaggcgag tacataccag ccgattcggg atagtccgct taccagggta 1330621 acgtctccaa atgaagaata cggttttgaa ccaaacagaa aagaatagtc aaaatcgatg 1330681 ccccagcaga tgacgaatac tgcggcaagc actccgagcg caatttgttt gccgcgtttt 1330741 gatctcaata aatcaaaatg atgtttattt aaataaaaac cgacaaggaa catcggtaag 1330801 aatacgaatg tccgtgacaa gctcagcgtg ctgctgacaa agtccagata accgatcagc 1330861 acggcgattc cgcagctgac aaacagcgcc cactgctttg aaagctttga aaaaggatat 1330921 aggagcaggt tccaaaagaa taagcttaca agaaaccata acgaccattg cggatcaatc 1330981 gggttcacat ttgccatgct ttcatcttgc ataatgtaat aaaagacgga ataaataatt 1331041 tggaaaatca aatacggaat aatcagcttg accgccagct tttttacata tcccgcccgt 1331101 ttaaagcctt tcgcgaaata accggataca agaataaatg caggcatatg gaatgtgtaa 1331161 atgaacttgt agaggtagag cataaaatga ttatcattaa taaaggaacg aaggatatga 1331221 ccgaatacaa caaggaatat caataaaaat tttgcgttat cgaaataact gtcccgcgat 1331281 ttactcatag catcaccttc tctttcatca gtcactaaga gattattccc tgctggtaca 1331341 tattttaaaa taaaagatga aaaaggaatc taaaaaaatg ctgattgtta ggtcgatgta 1331401 aagtgacggt aaggatcgta gaaaatgtct tcgtaatgta atgacgctga aattttctga 1331461 aatttatagg gcaaatgaag gaagttcccg cattttgtag aaatattgag ggataggttt 1331521 tgaagaagga gtgtacatgc atggaaactc ttggtgtcca gacaaactcg gagctgcgag 1331581 aggaactgaa tcgcctcaaa gaagaaaacg cgcgactgaa aaaggaattg aatcagcatc 1331641 aagtgattgt caacaatacg ctcgatgcta tttttatttg tgataacgaa atgcggattg 1331701 ttcaggcaaa tgaagcaaca gaaaggatgc ttcaagttga ctcggaagat ttgaaaaagc 1331761 gttctgtttt ggattttttg ttttcaatcc caaaggatga actgaatctt tccgtaaaga 1331821 agttttttaa aaaaggcttt ctgtggaagg aggttccgat caggcttgat tgcggggcaa 1331881 caaaatacat agagtttctg gccaaaagag gtattggtga ggatttcttt tttgttgtca 1331941 tgagggacat atcttctaag aagattctgg agcgggaatt ctctatgaat gaacagcttt 1332001 ttaaggactt gtttgacaga gcagttgacg gaatcgtcct gtttgataaa gatggcggtt 1332061 ttattgatgc aaatttgtcc ttttgtaaaa gctttgaaat caatcataat gagctgtctc 1332121 atttatcttt gtatgagttc atagacagcg gctcacgaaa agatttcgac aatatctgga 1332181 aggcgctcaa ccgcaaggga aaagcgaagg gggagctgcc tgtcaagctt cgttcaggag 1332241 ttcaaaaact atttgaattc acgattacat caaacatcat cagcggtttt tatatgtcca 1332301 ttatgaggga tatcacagag aagcggtcta tggagctgca gctctttaaa agtgaggagc 1332361 gcttcagaga aatctttgaa aatgcaatgg acgccatcat catctggtcg aatgacggaa 1332421 gaatcgtaaa agcgaatcaa tcagcctgta aaatttttga gctgccgatg aatttgctgt 1332481 tgaaaagaaa gctgtgtgat tttctcgttg actcgcagca gaaatacagc ataacgaaga 1332541 ggaaatacgc aaaatacgga gagatcagag aagagctgct gtttcaaatg gggaacggcc 1332601 aattcaaaga gcttgaattt acttcaaaac ggacaatcct tgaaaatcag catttgacga 1332661 tcttaagaaa tgtaagcgac agaaagcgga tggaaaagga gcttcgggaa agcgagctga 1332721 aattcagaaa agtgttcaac ggatcaatgg acggcaatgt attgttcgac aatcaataca 1332781 ggatcatcga cgccaacccg ttagcaagcc atattttggg cctgtcacat gaagagatca 1332841 aacagcacag cctgttagat attatttctg cttatgaaat agaaaatttg gcatcaccgg 1332901 caaggcagat taattttgat gaaatggaca acgaaattcc atttttgctg agcagcggtg 1332961 ataacagaaa actcgaattc tcatttaaac ggaatattat tcaaaatatg aacttggcta 1333021 tctttaaaga cgtaacagag cgaaaagaat tggaggagcg cctgcgcaaa tcagataccc 1333081 ttcatgttgt cggcgaactc gcagccggta ttgctcatga aatcagaaat ccgatgactg 1333141 ctcttaaagg cttcattcag cttctgaaag ggagtgtcga gggagactac gccctttact 1333201 tcaacgtgat cacctcagaa ctaaagcgca tcgaatccat catcaccgaa ttcttgattt 1333261 tagccaagcc ccaggccatt atgtatgagg aaaaacatgt tacccaaatt atgagggaca 1333321 cgatagacct tctaaatgcg caagccaatc tcagcaatgt acaaatgcaa cttgatttaa 1333381 ttgacgacat tcccccgatt tactgtgaac cgaatcagct gaaacaggtt tttatcaata 1333441 tattaaaaaa cgccatcgaa gtgatgcctg acggcggaaa tatttttgta acgataaagg 1333501 cattggatca agatcatgtt ctaatctcct taaaagacga gggaatcgga atgacagaag 1333561 ataaattaaa gcgacttggt gaaccgtttt atacgacaaa ggaacgggga actggacttg 1333621 ggcttatggt aagctataaa attattgaag aacatcaagg cgagattatg gtagaaagtg 1333681 aagaagggaa gggcaccgtt ttccatatta cgcttcctgt cagacagaat gctgaagaaa 1333741 gaaggaatga tgaatgaact actatacgac agccgaaacg ccgctcggtg aacttatcat 1333801 tgccgaagag gaggaccgga tcactcgtct atttctcagt caggaagatt gggtggattg 1333861 gaaagaaacg gttcagaata ctgagcataa ggaaacacct aatcttgcag aagcgaaaca 1333921 acagcttcaa gaatatttcg caggcgaaag gaagacattc tccctgccgc tcagccaaaa 1333981 gggcactcct tttcagcaaa aagtgtggca agcgctggag aggattccat atggcgaatc 1334041 ccgaagctat gcggatattg ccgctgctgt cggcagtccg aaagcggtgc gcgctgtcgg 1334101 gcaggctaat aaacgtaacg acctgccgat ttttgtcccg tgccacagag tgatcggcaa 1334161 aaacagtgcg ttaacaggat acgccggaag caaaacggag atcaaagcat ttttgctaaa 1334221 catcgagcga atctcctata aagaaaaata aaacatatgg cacgttccct tttttcacgg 1334281 ccgacatatc attttattaa gttaaaaaag ttggtctgat gaaaaaggag gacaaagcaa 1334341 ttgaagccga gccgctctga gaaacttgcc gtttttgccg aactgtttgt gaaactgcat 1334401 atcttatcaa gcgctcaaaa agatgaaatc atcaatgtta acaaaaagaa acaaaaaaac 1334461 cgctgactcg gctccaaatg agcaaagtcc agcggttttt taatgcacct tttctccttt 1334521 aaacagctgt tcaatctctt cttcatagtt tccggtcata atcccttttt ctgtgatgat 1334581 tcctgaaatg agatcatgag gtgtaatgtc gaaagcggga ttaaagacag gcacattgga 1334641 tggagcggtc cgaactccgg aaatctgcct gacttcctcg ggatctcgtt cctctatcgg 1334701 gatatcagcg ccgcatttga cctttgtatc aaatgtagat aaaggtgcgg cgacaaaaaa 1334761 cggaatatca aaggcgtttg ctaaaatagc aagaccgtat gtgccgattt tatttgccgt 1334821 atcaccgttc tttgcaattc ggtcggctcc gacgataaca gcggaaattt gtttttcctt 1334881 catcgtatgg gcggccatgc tgtctgtgat cagagtgaca tcaatgcccc cctgcatcag 1334941 ctcccaagca gtaaggcgtg aaccttgcag gacaggcctt gtttcacagg cataaatgtg 1335001 taatcccaaa tctttttgtt tggccaagta aaacggagct agcgccgttc catagcggct 1335061 tgtcgcgatt gagccggcat tgcagatcgt catgatcctg tcgccttttt tgaaaagctg 1335121 cagggcgttt tggccgatca accggcacgt ttcctcatcc tcgacctgaa tctgaatggc 1335181 ttcatggaca aggtttgttt ttgcttcatt tacggaaatc gcgttttcga ccgaatgact 1335241 cagtctctca agcgcccatg acaaattaat ggcggtaggc cgtgagctgt ttaaatattg 1335301 tttgatgtct tccagtctgc ggcggaattc cgtgacattg tctgtttcaa tgtctttggc 1335361 agcaagcgcc agtccgaagg cagctgtaat gccgatcgcc ggagcgcccc ttactttgag 1335421 cgtgacaatc gcatcaaata catcctcttt cgtcgtcagc tccaaatatt ccgtctcatc 1335481 aggaagcttt tgctgattta aaatggtaat agctgtttct ttccattcaa cagaacgtgg 1335541 aacagcaaat gaatgggtca tgaatagatc attcctttac aagtaactta aataattcaa 1335601 taacatctgt tatcgttttg aattccgaac gtttttcgat aaaggctgtg ccggtttcga 1335661 gcgccaagcg ttttctgccg attcgtttat caaacggcac gatcgtatcc aggtcagcta 1335721 catgggcaag gccgatcgtg cgtcgtatca gctcacagcc cgcaaatccg attgcttctt 1335781 caaaaatatg gctgagcgta tcagtgaggt aaccgtcgat gttggcgtaa acatccagac 1335841 tgtccttctg ccaggcttca ctaaacgtct cttcaaacgt ttcccagacc tggttgacat 1335901 gttcatataa cggctctctg tcagccccgt cacggctgag tgcgttcaaa aataagttgg 1335961 cgataaattg ccctacatca aagccgatcg gtccgtaaaa agcaaactca ggatcaatca 1336021 cctttgtttc gtgctcactt gcgaaaatgc ttcctgtatg caaatcacca tgaatcaacg 1336081 tttctgcaga cgttaaaaat gactttttca gcttagcggc ttcgatttta acgctgtcat 1336141 tattccaaag cttttcgaca aaaggacgaa gctcttcttc aaaatcattt gtgtcatggt 1336201 cgaagaaagg atctgtaaaa acaagtcttt ccgtaatgtc gcatagctct ggatttgtaa 1336261 actgtttaac aagctgtttt ttcaccttag gttcaagcgc gtaatctgat gagtagaaaa 1336321 gtgtttttcc taaaaattca ccgatgtgct gcgacagatg aggatagttt tcaccctcaa 1336381 tgagtccttt tcttgcgatc ttgaggtgag agagatcctc catgacggta accgccattt 1336441 ccgtatcaga ataaaacact cttggaacca ggtgaggcac atgctcgccc tgacggatga 1336501 gagcgctgct ttcgattctt gcacggtcga ttgtcagcgg ccagctttct cccaccactt 1336561 ttgcatacgg aaccgcctgt ttaatgatca atgctctgtc atgttcttga tcataaatat 1336621 gaaaaacgta atttaagttg ccgtctccga tctcctggca tgtcagcgtg cttttgcttg 1336681 gaaataggcc aagcttcacc gccaacgcca cagcggagct ttcatttaac gtttcgtata 1336741 aaggtgtttt tgtgactccc atcatcataa cctccaatta tgtaattaat taatatgtgg 1336801 ccgtaaaaaa gcctccttct cagagagaag gaggcttaac atctatgtcc gcctctctta 1336861 tctctcagat cagatctgaa tggaattagc accgtgcctt aagagaccag cgtctcggcg 1336921 cgaaaaaaat gcgccccatt tcacaatgga attacggtcg gttgcttttg gggtcaaaag 1336981 gccaaatccc tcgcccaact ctcgataaga gaatatattc acttgtttga caattctaat 1337041 ttatcagttg atgaacatgg taacaggtaa tttagttagt tgtcaatata ttttttaata 1337101 taaatctttt ctgatatcat cgaaaacagg aatgctctcc cgaacttctg cgctttcttg 1337161 aaggtcgatt tccgctcgga ctatgccttc ttcccggccg ccttcagcaa gtacacgtcc 1337221 ccatggatca ataatcaggc tatgtcctgc aaattcatta tccggatttg aaccggtaca 1337281 attgcaggct gcgacaaagc attggttttc aatggcccgc gcaataagca ggcttttcca 1337341 atgatcaagg cggggaagag gccattccgc agaaataaac agcacgttgg cgccttttgt 1337401 cgtatgtttt ctgatccatt ccggaaaacg gatatcgtaa cagatcaatc cagagctttt 1337461 gacgccgtca agctcaaagt atccgtcttc ggaaccggct gataaataca gatgctcatc 1337521 catcagctga aaaagatggg cttttctgta ctctttaatg atttgccctt ccttatccgc 1337581 gatgtacatt gtattataaa catcagaatt cttcctgaca gcgaccgatc cggcgacaat 1337641 atgaacacca tgtttttttg ccgttttctt cagccagctc tgagcggagc ggccgtcttc 1337701 gtcagcgagt tcatcaagat tggccagatc atatccggtc gtccataatt caggcagaac 1337761 aagaacatca gcatgtttgc tttctttttc gatgaaaaat tcagcctttt ttatattttc 1337821 cgaaggtttt ccgtatgaaa tatcaaattg aagacaagat atcgtccatt tcatcttttt 1337881 aacaccccaa atttttcttt acttttttca tttaaccata tatgatgatg gactatcatt 1337941 tcaagatttt tttagaaggt gagaatagat gaaatttgaa cagtctcatg tattgaagga 1338001 attgcctaaa caattcttcg cttctctggt gcagaaagtg aaccgaaagc ttgcagaagg 1338061 acatgacgtt atcaatctgg gacagggaaa tccagatcag ccgactcctg agcatattgt 1338121 tgaggagatg aaacgagctg tcgctgatcc tgagaatcat aaatattcgt cttttcgcgg 1338181 ctcataccgt ctgaagtcag cggctgctgc attttacaaa agagaatacg gcattgatct 1338241 ggatccggaa accgaagtcg ctgtattatt cggcggaaaa gccggtctag tcgagctccc 1338301 gcaatgcttg ttgaatcccg gtgatacgat tttagttccc gatccgggtt atcctgatta 1338361 ctggtcgggt gtcacacttg caaaagcaaa gatggaaatg atgccgctcg taaaggacag 1338421 agcgtttctc cctgattaca gcagcataac cgctgaaata agggaacagg cgaaattgat 1338481 gtatttgaat tatccgaata atccgactgg agctgttgct acttccgagt tctttgaaga 1338541 taccgtgcgt tttgcggctg aaaacggaat ctgcgtcgtt cacgattttg cttacggcgc 1338601 tgtaggattt gacggctgca agcctttaag ctttttgcag actgaaggtg cgaaggatat 1338661 cggaattgaa atttacacgc tgtcaaaaac gtataatatg gcaggatggc gggttggctt 1338721 tgccgtcgga aacgcttcgg tcattgaagc gatcaatctt tatcaagacc atatgtttgt 1338781 cagtcttttc agagcgactc aggaggctgc agcagaggca ctgttagccg atcagacgtg 1338841 tgtggcagag caaaatgcca ggtatgagag caggagaaac gcttggatca cggcatgccg 1338901 ggaaatcggc tgggatgtaa cagctcccgc aggttctttt tttgcatggc tgcctgtgcc 1338961 tgaaggctat acttctgagc agttctcaga tcttttgctg gaaaaagcga atgtggcagt 1339021 tgcggctgga aacggcttcg gtgaatatgg cgagggctac gtcagagtcg gacttttaac 1339081 aagtgaagaa agacttaagg aagccgctta tcgaattggc aaactgaacc tgtttaccca 1339141 aaaaagcatt gacaagacct tataacgatg ggataattca aaataattta taaaatctat 1339201 attttcttat caagagcagg cagagggacg agcccgatga agcccggcaa ccgacttata 1339261 aagcacggtg ctaattcttg cagctagcgg ctgagagata agattcggac gagaaacgaa 1339321 acctctttag acgcgattgc agtttgaaga ggttttttga tatggatgaa aatgaaagga 1339381 gctctggcat gagtgagtta ttagcgacat atctcctgac cgaaccggga gccgatacag 1339441 agaagaaagc agaacaaatc gcaacaggat tgacagtagg ctcctggact gatctgcccc 1339501 ttgtaaaaca ggagcaaatg caaaagcaca aggggcgggt gataaaagtt gaggagagag 1339561 agggaactgc tgcatcagaa aaacaagcgg tcatcacaat tgcctatcct gaaatcaatt 1339621 tctctcagga tattccggct ttgctgacaa cagtgtttgg caagctgtcc ctggacggaa 1339681 aaatcaaatt aatcgatctt cacttctctg aagcatttaa gcgtgcactg ccgggaccga 1339741 agtttggcgt atacggcatc cggaagctgc tgggagagtt tgagagaccg ctgttaatga 1339801 gcatatttaa aggcgtaatc ggaagggacc tgagtgatat taaagaacag ctccggcagc 1339861 aggcgcttgg cggagttgac ttgattaaag acgatgaaat tttctttgag actggtctag 1339921 cgccttttga aacaagaatt gcagaaggaa agcaaatatt gaaagaaacg tatgaacaaa 1339981 ccggacataa aacgctgtat gcggtgaatt tgaccggacg tacggctgat ctgaaagaca 1340041 aagcgagacg cgccgccgaa ttgggagcgg atgcgctttt gtttaatgtc ttcgcttacg 1340101 gcttggacgt tatgcaaggc cttgcagaag atcctgaaat cccagttccg attatggcgc 1340161 atccagcagt gagcggagcg tttacgtctt ctccgtttta cggtttttct cacgctcttt 1340221 tactcggaaa attaaaccga tattgcggtg ctgacttcag cctctttccg tctccatatg 1340281 gttcggttgc gcttccaaga gcagatgcac tggcgattca tgaagaatgt gtgagagagg 1340341 atgcttttaa ccaaacattt gctgttccgt cagcaggcat tcatcccggc atggttccgc 1340401 tattaatgcg tgatttcggc atagaccaca ttattaacgc cggaggaggc gtacatggac 1340461 atccgaacgg tgcccaaggc ggggggcgag cgttcagagc tattattgat gcggtcctag 1340521 aggcccagcc gattgatgaa aaagccgaac aatgcaagga tcttaagctt gcgctagata 1340581 aatggggaaa ggctgaagcc gtatgacgac tcgaaaacct tttattattt gtgattttga 1340641 cggaacaatc acgatgaacg acaacattat aaatatcatg aaaacatttg ctcccccaga 1340701 gtggatggca ttaaaagacg gcgtactttc caaaacgctg tcaatcaagg aaggtgtcgg 1340761 gcggatgttc ggccttctgc ccagcagttt aaaagaagag attacaagtt ttgtattgga 1340821 agatgcaaaa atcagggaag gctttcggga atttgtagca tttatcaatg agcacgagat 1340881 tccgttttat gtcataagcg gtggaatgga cttttttgta tatcctttgc ttgaaggcat 1340941 tgtggagaaa gaccgcattt attgcaacca tgcttcattt gacaatgact atatccatat 1341001 tgactggcct cattcctgca agggcacatg cagcaatcaa tgcgggtgct gtaagccgtc 1341061 ggtcatccat gaactttctg aaccgaacca atatatcatc atgatcggtg attcggttac 1341121 agatgtggag gcagcaaagc tgtctgacct atgctttgca agggattatt tattaaacga 1341181 atgccgggag caaaacctca atcatcttcc gtatcaagat ttttatgaga tcagaaagga 1341241 aattgagaat gtaaaggagg tacaggaatg gctgcaaaac aagaacgctg gcgagagctc 1341301 gctgaagtaa aacgggaatt ggcagagaga gattggtttc cggcgactag cggcaatctg 1341361 tcaattaagg ttacagatga gcctttaaca tttctcgtca ctgcaagcgg aaaagataaa 1341421 cgcaaagaga cggttgaaga ttttctgctg gtcgatcaaa acggagagcc tgctgaaagc 1341481 gggcattctc tgaaaccgtc agcagaaacg cttttgcata cacatttgta caataaaacc 1341541 aatgccggat gctgcctgca tgtccatacg gtaaacaata atgtgatttc agagttatac 1341601 ggagaccaaa agaaaatcac attcaaaggc caggaaatta taaaagcact cggcttgtgg 1341661 gaagagaacg cagaagtgac cgttccgatt atagaaaatc cggcacatat cccgacgcta 1341721 gcggcactgt ttgcggaaga gatttcagaa gattcaggag ctgttctgat ccgaaatcat 1341781 ggtattacgg cttgggggaa aacagcattt gaggcaaaaa gagtgcttga agcgtatgaa 1341841 tttttgttca gctaccattt gaaattgaaa acactcgagc atcagctggt taaataaaag 1341901 gaggaattga aatggctaca attcgaattc atgatgaggc aaatacaacg attgaaaatc 1341961 aagaggaagt ggcaagcttt ctggacagtc aagaggttat ttatgagcaa tgggatatca 1342021 cgaggcttcc ggaacatctc tcagagaaat atgacctgac agaagaagaa aaacagcaaa 1342081 ttcttgatac cttcgaaact gaaattaaag atatctcaac ccgccgcggc tataaagcac 1342141 aggatgttat ttcattgtca gacagcaatc cgaaacttga tgaactgctt gaaaacttta 1342201 aaagagagca tcaccataca gacgatgagg ttcgttttat tgtaagcgga cacggtattt 1342261 ttgtcattca aggccaggac ggcacgtttt ttgatgtccg tttaaaccct ggagatttaa 1342321 tctccgtgcc tgagaatatc cgccattact tcacgcttca ggaggaccgc aaagttgtcg 1342381 cggtgagaat ttttgtcaca actgaaggct gggttcctat ttatgaaaaa gacagcgtga 1342441 atcaataagc gtgagatagc cccgttcatc gaacggggct ttttatattt attgcaaacg 1342501 ccacttttca tattgtgaca gttctttttt aatcagtgtc caaatcaaac ctaaaacagc 1342561 tgcatcgtca atgaatccaa gaccgaggat tacgtctgga atgatatcga gcggcatgac 1342621 gatatacagg attgcggcag ttaacagcaa aagtgtttta acctgtgaac gagggtagtc 1342681 gccatttcgc caatcgcgaa gcatctgaaa aaaagtagtg atgtgctgga tacatttttt 1342741 tcggtttttc ctctttaaaa tcgcttttcc gcctgccgct ccgagcatta ttgctttctt 1342801 tttcttcatt gggcatacct cctgcctggc ggcgtgttta agatattctt cacctgggta 1342861 ttgttcttct aatcctatca atatatctat tatacctgaa aaattaactt atttaatgaa 1342921 aatatgttta caaataaagt ataatctgta ataatgcaca ataacccaat caaacttgtt 1342981 tcctatttct tagcggcgag gggtgaagtg aatgggcggt tcttctgaac aagaaagatt 1343041 gttggtgtct attgatgaaa aaagaaagtt aatgatagat gccgctagaa agcagggatt 1343101 tacagggcat gacacgatca ggcacagtca ggagctggat tgtttaataa atgaatatca 1343161 tcagcttatg caagaaaacg aacattccca agggattcaa ggccttgtaa agaaattagg 1343221 cttgtggccc cgcagagatg ttatgccagc atatgatgca aataaatagc ggcctatcag 1343281 atgcatatat aaagagagag cttttcggaa gcgctctttt tttctggaaa aaattcatat 1343341 gaaagaggga actaatgaag gaactggcga ttctcattac cgaaatggtc aatcaatttc 1343401 atgatgcttt tatttcctta tgcggaatat ttggcattca tttaactgac aaagaaatgc 1343461 atttttgggt gatcggcatt tttggcatat tctttttcgg cgtcactcac gctgtgttta 1343521 catggctttc taaatggagt atgacagcct tgtcctttat ctataccgtt acagtcatca 1343581 ttgtcatcgt atttgcgatt gagattcagc aaaaggtgac ggggagaggg aatatggagt 1343641 ttttagatgc cacggaaggt ataaagggtt ttttagtatt ttttatgttt tttttgcttt 1343701 tgaaaatgct gttgcgtttc atcaaaatcc ttttttctgg aagaccagca agcaaatcga 1343761 atggcaatgc ccgatcacga agataaaaaa ccctcctgac atggtcaggg gggctatgat 1343821 gcggatacgg ggagggtgat cgtcacctct gtgcctcttc gcacttcact ttcaatatga 1343881 atagagcctc cgtacatcag cacgatccgt ttacaaacaa caaggccgag accggttcct 1343941 ttttctttag aagtaacaaa gggaaggaag atgtgatcca gcatttcctg agaaatccct 1344001 tcaccgttat ccacaacttt gattatggct tttttatcta aagctcctag ggagatcgtc 1344061 agtttgcctc cttcaggcat tgactcgagg ccattttttg ctacatttaa aatcacttgt 1344121 ttaatatgat cttttgtaca ttttacgagt aagggctgct cggttagata ctgtaattcg 1344181 acttcaacat tgtatagatt gccctcagaa taaatgatcg gcataatttc tccgataatg 1344241 tcctgaagtg agttcagctc ccatttttca gctgtcggct tgccgagaac gagaaactca 1344301 ctcactattt gattgatgcg ctttatctcc tgttcgataa tggagaagta aagctgatct 1344361 tcctcacctt tatatttctt ttgcaacagc tgaataaagc cgcttatccc ggtgaggggg 1344421 ttacggattt catgggctgt gctggcagca agcgtcccga tcagctctaa tttttgcgcc 1344481 tcgttttctg agcgctccag ctgggtctgc cgcttcagca aataatacag cacgagaata 1344541 aaaaggatat tcagcagaac aataatacat gaaagcggaa gcacaaggct tttcgacagt 1344601 tcttctattg tgaccgggtt cggatagact ttcatattcc agctgatatc atccagatat 1344661 ccgctgacag gtttctgatc ctctgcatga gaggcttgtc cgctcgcaaa aatcattttc 1344721 ccgtcttggt tcacaacttc aatataaaca tcagggctta gtaagttaat gagatttttc 1344781 aaataatcaa tttgaatagc tgcgacaaga taatctgtca cattacgttt tgagtccaaa 1344841 acaggcacac aaattgtgaa aattggctga ccagtaattc tgctcgaata actatctgaa 1344901 atgactgtct ttttagtttc ctttgctttt ataaaaaaag atctgtcggc caggtttact 1344961 ttcgttttta attcggttgt gcttgcggtg acgtctcctt tggcattgag aaaatagaga 1345021 ccggaaaatc tcggctctga atcaaaggtc ttttccaaaa ttgattgcat tttctttata 1345081 tcaaccggtc tgtcgatggc gatggacaag gaggtcattc tcgccattgt ttctccgatt 1345141 aaataattga ttttgttgcg gtgaaggttt agcaggacac ttgcttcttg tttatgttct 1345201 gcagctattg tatctttttc tttttcatat acgaaaaagc tgatgacgat tgccggaatc 1345261 acgaccagta tgatataaag tttgactctc ccgcaggcgc cttttagtat tttcaatttg 1345321 catcgctcca acatacacct gattagaggt attatatcat tgtttcttct tctttaataa 1345381 gaaaaaataa ccaaaaaaat tagaaaaaga tgttggcaag cttacatttt aaaaaagaag 1345441 agaaatattg gaaagatttt tattgacatt ttggtctttg tttattaatg tttctctgta 1345501 acggtttcta aaaggatgat tgagacatga cagaaaaatc actgaagtta tttatcgtgc 1345561 tgtcgcgcgc gtatcggtct attaacgatc atatgaataa gcatattcat aagcatgggc 1345621 tgaatccgac tgaatttgct gtgctagagc ttttgtacca taaaggcgat cagccgctgc 1345681 agcagatagg agataaaatt ctcttggcta gcgggagcat cacatacgtt gtagataagc 1345741 tggagcaaaa agaacttctc attcggaaag cgtctcctac agacagacga gtgacatttg 1345801 cgcaaattac tgaaaaaggc atcggtcttt tgaacgatat tttccctgat cacgctgctg 1345861 aaattgatga aatgatcagc gtattaagcg aagaagaggt agagatgtgc accgaaatgt 1345921 taaaaagagt aggattaaac gcaaaacagt ttcataataa gtaaaaaaag gaagcctgat 1345981 atgtcacaag gcttcctttt ttgctatttt tcatttgttt ccgctgcgcc tctcggcaaa 1346041 atgagaactt caacccgccg gtttttgctt cggccttccg cagttttatt ggaagccacc 1346101 ggtttatact cgccataacc cttggcgctg aacacttttg catcgagctt ggggttttca 1346161 atcaggagcc ccataaagtt taccgctctc atgacgctta aatgccagtt tgattggaat 1346221 tcagaatttt taattggcat attatcagta tgtccgctga taatgatatt tcttggcggg 1346281 ttaatcacaa gaagatttga aatctctttt gcaagcggca catcttcctt acggatggtc 1346341 gcttttccag aatcgaagaa gatgctgtct ttaatcgtaa tcagaaggcc ttcactagtc 1346401 atcttcgtct ccagctgatg ttccagcttt ttatctttga tgaacttttc cacctggctc 1346461 ttcacatttt caagttcttc ttgatcagct gctttttctt tttctttctt gtttttctct 1346521 ttctcttctt tttccttttt cacttcatcg atgccgtctg actcgttttc aggaggagtg 1346581 acactggagt agtccagtac accggttccg cctgtaaaaa cttcattaaa tgattttgag 1346641 agcatttgaa acttagctgc gtcaatcgag ctgctcgcgt acagcacaat aaacaatgcc 1346701 aggagaagag taaggatgtc ggcgtaagga acgagccatg attcatcaac gtgctcgtcc 1346761 tcatgcttct tcttcttttt tctcgccatt ttgcgcctct ccttgttctg caaatttcaa 1346821 gcggtccttc gcaggaagat acattaaaag cttttgttcg atgactttcg gtgcttgtcc 1346881 ttctaaaacg gataaaacac cttcaatcat gacctcacgc agttttactt cctgttttga 1346941 ttttcgtttt aatttatttg cgaaaggatg ccataacaca taccctgtaa agataccgag 1347001 aagtgtggca acaaaggcag cactgatggc gtgtccaagc tcatctgtgt tatccatatg 1347061 agagagagcg gcaatcagcc cgattacagc gccgagtact ccaagtgtcg gagcgtacgt 1347121 tcctgcttgt gtaaaaatag cggctcctgc ttggtgcctg tcctccattg cttcgacttc 1347181 ctctgtcata atatctctta taaattccgc gctttgcccg tcaacagcca tgctgagccc 1347241 gtttttcaag aaagcatcat ctacatcctc aatgcttgct tctaaagcaa gcagaccttc 1347301 gcggcgtgca agctgagccc attcagagaa cataggaatg agttcctcta ttgtgagctg 1347361 tttattttcc ttaaataaca ctcgaaacag cgtaggcact tttttaattt cttttgttgg 1347421 gaacgcaata acgactgctg agattgtccc ggcgataata attaaaatgg cagcggggtt 1347481 tgcaagggcg ctgaaactga cgcctttcag aaccatcccg acgctcaatg ccacaaaagc 1347541 aagaataata ccgattaacg aagttttatc catagttttc accaaatcct tttttactag 1347601 cttgtctatg gttaatatcg gttttggtgc ccggaacttt agggacattg tgaatttgtt 1347661 catgaaatat tcaaggaaga ggcatagaag ggagaaataa acaaaaacgg gctctccaaa 1347721 attgaaaagc ccgggggtct actgaaatta gcagcttgct tgcaagctgt ccttcagatg 1347781 gtattcatat aatagtagaa atacatattc actgtatata aacatgttcc atccctcctt 1347841 aaaaaagtgt aaaggatgaa gggaagtagc gcttcaggag aagggacggt aatttctaag 1347901 tcaagagtat gaaagtataa aaaaaagcgg cttcctaaaa ggaaaccgct gattgttatt 1347961 ttgctcgcac tttgatttta tcatcttcta aaatcacgtg aaaacttgtg atctcgccat 1348021 tatcaagcag cagatcggtc atttcatcct caacccattc ttggatggtt cttctaagcg 1348081 gacgtgcacc gaatgaaggg tggtagccca gctcagcgat tttttctttc gcttcatctg 1348141 tcacattcaa gctaatgccc cgttccgcca atgtttcttc aagttctcca agaagaaggc 1348201 tgacgatttt gacaagatgt tctttttcca atgagcggaa ctcaataatg ctgtcaaaac 1348261 ggttgaggaa ctcaggttta aagaacatgc tcagtgaatc aattaatgtt tgttcttcga 1348321 tgacactgtc atctgattgg aaaccgactt tcgtttgttt ctcaccagca cccgcattac 1348381 ttgtcatgat gatcacagtg tctttgaagc ttacagttct gccttggctg tctgtcagac 1348441 ggccatcttc cataatttgc aggaacatat gctgaacgtc tgggtgtgct ttttcaatct 1348501 catccagcaa cacaatgctg taaggattgc ggcgcacctt ctcagttaat tgtccagctt 1348561 cctcatggcc gacatatcca ggcggtgaac cgataatttt agatacggcg tgtttctcca 1348621 tgtattcgct catatcgagt cggataatag cgtcttttgt gccgaataat tcatctgcca 1348681 gtgttttaga aagctctgtt ttccctacgc cggtaggacc gacgaagagg aaggagccga 1348741 ctggtctgtt tttggatttt aatccggcgc ggcttcgtct taccgctttt gccacttttt 1348801 gaacagcggc ttcttgtccg atcacgcgtt catgaagttt tgcttcgagt tctttcattt 1348861 tcgtttgttc gtctgcctgc agtttgccga cagggatgcc tgttttttgt tcaacaattt 1348921 cctgaatgtg ctcagcttcc acagtgacag cggtatgagc ggaggagctg ttcagttttt 1348981 tctccaatgc gagttcttca tcacggagtt ttgccgccag ttcgtaattt tcttcttcca 1349041 gggcttttgt tttttcggct tcaattgcag ttaagcgttc agcggcatcc tcatcattca 1349101 gttcatcaat taacaggttg gcttttgaac ctgcttcatc taataaatca attgctttat 1349161 ccggcaggtg tctgtcctga atgtagcggg atgataaagt gacacatgct ttgattgctt 1349221 catcactgaa tgttacgcca tggtacgcct cgtatttgtc tttaatccct tgcagaatga 1349281 ggatagcctg ttcaattgaa ggctcctgca ccatgacagg ctgaaaacgt ctttccagcg 1349341 cggcatcttt ttcgatttga cgatattctt tcagtgttgt cgcgccaatg acttgcagtt 1349401 cgcctctggc tagggccggt ttgagaatgt tgccggcgtc cattgatcct tctgcagagc 1349461 ctgcgccgac gagaaggtga atttcatcaa tgaacagaat gacatttttt cgttccttca 1349521 gctcagtgat cagctgtttc attctctcct caaattggcc tctgatccct gtgtttgcaa 1349581 caagagatgc aacatcaagc aagtatagct ctttgttttt tagtttgttt ggaacatcac 1349641 cttcagcaat ttttaaagcg agcccttcag cgatggcagt tttccctaca cccggctcac 1349701 caataagaac cggattgttt ttgtttcggc ggtttagaat ttcgatcact cgcgccactt 1349761 catcatcacg gccgatgacg ggatcaatga gaccggcttt tgcaccgttt gtaatatttt 1349821 gagccagctc atcaagcaac cctttttttt cgctttgttt tgctgcgctc tgttctttcg 1349881 gctggaatgc ctgttcaaac ggaaatccga aagattgagg acccatactc attgaaggtt 1349941 tacgggtcag ttcgttatag caagtttcac aaagaaccat ctgtttatga acggaattta 1350001 tttgcatgtt aaggcgaatc gtcgcctcgt tttgatgaca atgttgacaa cgcatttgcc 1350061 aaaacctcct taataatttg atcatctttg accaatgaaa gtgaataaaa aggtctattg 1350121 ggtttgacct tctttgacta ttagtatacg gcaaacttaa cggcattcaa accaatatgc 1350181 tcaaagcaga ctgaatattt gactatcttt gaccaattga tttttaaaaa aggccggttt 1350241 gtttgaccaa ctttgattaa tagtatactc tgactatctt tgactttcaa gtcttatgca 1350301 caaaaatttt tgatttgtta caaagtaaaa catgttttct tcgtcttttc aaggaacttg 1350361 tctcataggt tataaaaagg catatatgga caaaactgcg gttcgttcgg agggaagaaa 1350421 tggaacaatc aaaagggtct gcaagtcagc ttgcttttgt gtatgtcggc acagtagtcg 1350481 gagctggatt tgcgactggg agggaaattg ttgagttttt tctgaagttc ggctggttcg 1350541 gttttttcgg cattctcgtc agcggcggaa tgtttacgtt actgggggcc aagctgatga 1350601 tcatttcaaa gcgaatcaat gccaagtcat atcaagaaat gaacatattt ttgttcgggg 1350661 cgacggctgg gcggattatc aatgtattta tgctgtttgt tctccttgga gttacatctg 1350721 ttatgctttc aggggcaggg gcgctttttg aggaacagct ggggatgtcc gctcagattg 1350781 ggatgctcat tacaatcggt ctgagtttaa ttgtgatgac tagaggagta aaaggcattt 1350841 tcggtgtcaa tgtgtttgtt gttcctcttt taatcatctt ttcaatgatt gtggtggccg 1350901 actcttttat attcagcgaa tcacgaaacg cagctcagtg ggtctggccg catcgctggg 1350961 attggctgtt atcagcagtt tcttacgggg ctttaaattt atcgcttgcc caagctgttt 1351021 tggttccgct ggcgaatgaa atgtcatcgg agaaagtgat aaaaaaaggc gctttaatcg 1351081 gaggcacgat gctgacgatt gtgctgtccg cgagttttct gtctttgtcg actcttccgg 1351141 atgtattttt gtatgatata ccgatggcgc aagtggttta tctctttgca cgatctgtcc 1351201 atttgattta tttactcatt attttcggag aagtgttcac atcagttatc ggtaatctat 1351261 atggattaga aaaacaagtg caaagctttc ttccagtgaa aagcaaatat atctttgcag 1351321 ccattatgat cacggcttat attacgagcc aaatagggta cggcaggctt atttcaacga 1351381 tttatccctt gtttggctat gtgagcctgg ccttcatagg cgctttgctt tgcaaaaaag 1351441 ctcctcggcg gcgcagttta taaatatata taatgaaacg aaccgtcact atagagcgat 1351501 aattgatcta ggaaccgggg actgactttt ttattgtcaa gaaaaacatc attatggtaa 1351561 gatagcagaa gtgaaaaaat tgaagaaaat ccgtgcgata tgcgggagag gttctagcta 1351621 caccctctat aaaaaactaa ggacgagctg tatccttgga tacggccttt tttatgtttt 1351681 tctagagcac cttccgaaaa aaggtgtttt tttgcgtgaa ttagctgtag cgatgtctct 1351741 cgccggcgtt tttattgcgg agaaggagag gaatcatgaa aaaagaaaaa gcaattgtcg 1351801 tatttagcgg cggtcaagac agcacaacat gcttactgtg ggccttaaaa gaattcgaag 1351861 aagtcgaaac ggtgactttt cattataatc agcgacattc gcaggaagtt gaagtggcaa 1351921 aatccattgc ggaaaagctt ggtgtgaaaa atcatttgct tgatatgtca cttttaaatc 1351981 agcttgcacc gaatgccctg actagaaatg atattgagat agaagtaaaa gacggcgaac 1352041 tgccatccac attcgttcca ggccgcaatt tggtattctt atcctttgcg tctatcctgg 1352101 cttaccaaat tggcgcgcgc cacattatta caggagtttg cgagacagac ttcagtggtt 1352161 atcctgactg ccgtgacgaa ttcgtgaaat cttgcaatgt cacggtaaat ctggcaatgg 1352221 agaagccgtt tgtgatccac acgcctctca tgtggctcaa taaggcggaa acgtggaagc 1352281 ttgcagatga gcttggcgcg ctggattttg tgaaaaacaa cacgctgaca tgctataacg 1352341 gcatcatcgc agacggctgc ggcgaatgtc cggcatgtca ccttcgttca aaaggttatg 1352401 aagaatatat ggtgatgaaa ggagagcgtg cataaattgt tatctcaaat ttatccgcag 1352461 gcccagcatc cttattcgtt tgaactgaat aaggacatgc atatctcagc cgctcatttt 1352521 atccctcggg aaagtgcggg agcgtgcagc agggttcacg ggcatacgta taccgtaaat 1352581 ataaccgttg ccggcgacga acttgacgat tcaggctttc ttgtcaattt cagcgtactc 1352641 aaaaaactgg tgcacggaaa ctatgatcac acgctattaa atgatcatga agatttttct 1352701 caggacgacc ggtattcgct gccgacaact gaagtcgtgg cgaaaacgat ttatgacaac 1352761 gtacaggctt atttagacac tttggagaat aagccgacct gtgtacaggt gtttgtccgt 1352821 gaaacaccga caagctactg tgtctaccgt ccgaaaaagg gtggtttgaa tggctaaagg 1352881 aattcctgta ttagaaattt tcggcccgac gattcaagga gaaggcatgg tgatcggaca 1352941 gaaaacgatg ttcgtccgga cagccggctg cgattattcc tgcagctggt gtgactccgc 1353001 tttcacttgg gacgggtctg ctaaaaaaga tattcgctgg atgacggcgg aggagatttt 1353061 tgcggagctt aaggacattg ggggagatgc gttttctcat gtgacgatct caggcggcaa 1353121 cccggctctg ttaaaacagc tggatgcttt tattgaactg ctgaaggaaa ataacatccg 1353181 tgcagcgctt gaaactcaag ggaccgttta tcaggattgg tttacgctga ttgatgacct 1353241 gacaatttct ccaaaaccgc caagctcaaa aatggtaacg aactttcaaa agcttgacca 1353301 cattttaact tcacttcaag agaatgatag acagcatgct gtcagcttga aggttgtcat 1353361 ctttaatgat gaagatctgg aatttgccaa aactgtgcac aagcggtatc cgggaatccc 1353421 gttttattta caagtcggaa atgatgacgt gcatacgaca gatgatcagt cactgattgc 1353481 acatttgctt ggaaaatatg aagcgcttgt tgataaggta gctgtcgatg cggagctgaa 1353541 tctcgtcaga gtgctcccgc agctgcacac cctgttatgg ggcaacaaac gcggagtata 1353601 atagaaagga agatgaacat gacgacaaga aaagaatcag aattagaagg tgtaacattg 1353661 ctaggcaatc aaggtacaaa ttatttgttc gaatatgcac cggacgtgct ggaatccttc 1353721 cctaataaac atgtaaaccg tgattacttt gtaaaattca attgcccgga attcacatct 1353781 ttatgtccta aaacaggcca gcctgacttt gcgacaatct acatcagcta cattcctgat 1353841 gaaaaaatgg ttgaaagcaa atcattaaag ctgtatctat tcagcttcag aaaccatggt 1353901 gacttccacg aggactgcat gaatatcatc atgaacgact tgattgaatt aatggacccg 1353961 cgctacattg aagtatgggg caaattcacg ccaagaggcg gaatttccat tgatccgtac 1354021 acaaactacg gaaagcctgg cacgaagtat gagaaaatgg ccgaataccg tatgatgaac 1354081 catgatttgt atccggagac aattgataat cgttaattat tccgttgtgt gatacggagt 1354141 gtaaaaggaa gtggagtcac agtaaaatcc gaacattcag cgttaatttt cagcggaaat 1354201 gtgacctggt cacagcgaag tgtgacccgc actaagctca ataaaagtgg gaaaagtcac 1354261 acctgaaaat ggctctactc atgggaattg tattaaaaag tgtgacctga ggtgcaacct 1354321 gaactgtgac ttttatgcag tgaaaaattg atagtacaga agcagattaa ggcgtacaat 1354381 ttgtacgtct tttctttttt atccgaaaga aaaaatgcct atctagagat cataggcatt 1354441 aaatattatt atcaatatct tcatttattt tttggctaag tttctgaacc ttctctttaa 1354501 catttgaaac agctcttttt tgaatttcat caattctcct gaatatagtc gatgacactt 1354561 cttattagaa cttcactttc aaaattgaat atctcattta tttctgactg ttcttcatct 1354621 gttaggtgat ggtattgaag ttgtttagca tttacttcag cagctacatc aatcctaact 1354681 tagttgttct ggttgtacaa tttcatattc accttctgca tactcttgct ccgcataata 1354741 gcctccccat tgacagagct cctgcaagat aggtttaaga gattctccaa gttcagtgga 1354801 tgaatattca accttcggcg gtacttgatt atacatcttt ctgctcacaa gtccactggc 1354861 ttcaagctct ctaagtgttt gaatcagcat tttctgagtt atatttggga taatgcgctt 1354921 taattcactc gttctctttg gtccattcat taaaaagtat aatacaaggc ctttccattt 1354981 tccgccaata acttcctttg tcacttcaaa cccacagcta aattttttca tgtctaaagc 1355041 tctccattcc acatttatta ctttttagtt actatatcac aaaaaagtgg gtacttccga 1355101 taatgtgctt actgaaggat actatatctt gtaagttgtt cttcaagtac ttaaaggtac 1355161 tagacataaa ataaaattaa ttctaaagga gtgttaagta tgggtaaatt tgaaggtaaa 1355221 atagcgcttg taacgggtgg aacaagtggg attggtcttg ctacagcaca aaaatttgta 1355281 aacgaaggtg catatgttta tattacggga cgtagacaaa acgaacttga taaagctgtt 1355341 aaccaaattg gcaagaacgt aaccggtgtt caaggtgata tttctaagct tgaagactta 1355401 gacaaactat atgacattat aaagcaggaa aaaggtaagt tggacattct ttttgctaat 1355461 gcaggcatcg gcaacttcct tccattaggt gaaattactg aagagcaggt tgatagaacg 1355521 ttcgacatta acgttaaagg aaccatcttt actgttcaaa aagcgttatc actattcccg 1355581 gacaaagtag gttctattat tgtaacgggc tctactgctg gatcaattgg caacccagcg 1355641 tttagtgtat atggagcatc taaagcagca ttaagagcac tagttcgcaa ctggattctt 1355701 gacctaaaag gtactgaaat ccgtgtaaat gtggttagtc caggaggtat tcttacacct 1355761 gcctacgatg agctttttgg tgatgcactt gaagaggtac tggaaaatag cagaaatact 1355821 gttccagctg gaaaagttgg gacacctgaa gaagtagcaa acgctgtatc tttccttgct 1355881 tcagacgaaa gcagttactt gacgggtgtt gaattgttcg tagatggcgg gctagcacag 1355941 gtataatttc actgcgcaga gattacaaat agtccccaaa aaaggttaat ggggatttac 1356001 ttgaagaagt cgtataaaaa agtcgttttc cttaaaggac agggaattcg acttttttat 1356061 atttgaattt gattaacgtt gtaaattcgc attttcctgg ggctactact aaatgacctg 1356121 taaaaaagat tacactgtga ataaatgtac ttaaagtaac gggggctctt gacttttaat 1356181 aaaaaataat atccctgtcc ttgtattcta atacttttaa aaatatttaa aggaatcctt 1356241 atgtcctgaa taaccacata ggaaaatatg ttgtaggttg ctttcttttt ttgtggggca 1356301 tcccacacaa gctatctcgt gatctcacac ctgaacgttt tttatagact agtaccgcga 1356361 caagttatat tacatataca taccaataaa gtagacatta aaaagtgaaa gagaggatgg 1356421 aaatgtgtga aaattctttt ccttgagagt catcccatgt ggctctatgg tttaccgaat 1356481 gggtttaggg aagcaggaca taccgtaatg atttccggtc ctgtaagtcg ggaaaatata 1356541 actgaaatga tagacgaatt taaaccagat ttaatagtat ctatgggatg gacaccagag 1356601 cattcaaggg aaaagcaggc ctggattcgc aacgctacta aaaaggtgaa tatccctctc 1356661 gtttattggg caactgaaga cccgctgcac actcaaaact ttactatccc gttaattaaa 1356721 aagatgaaac cggattttgt tttcacggtc acgccttctc tgtgtaaaac ttatgaaagc 1356781 atggggatta aagcagctca cttagacttt gcatttcacg aaagtataca tcaccagatt 1356841 aaaccattag cgaaatacag ttgtgatata gcagtggtgg ctaatgctta ccctaatttt 1356901 cttgaagaac atccggaagt gttccgttcg tcctctttaa aaacgcttat tcgtcctctt 1356961 atacggaagg gtattcgcat tgatttttgg gggagaaact gggaaaaaat gagtaaatat 1357021 ataggaagag aaattccccg caattggatc catggatacc ttgattatac tgaagcatat 1357081 aaagtttaca gttcagcaaa aatcattatc ggtttgcaaa actgtgaaag ccaacttaca 1357141 caacgcacct atgagattct tggttccggg gggtttttat tgacatcgga tacaccagca 1357201 gttcgaggta aattcaaacc tggccgcgat ctcatcgttt cttcctcccc aaaagaaaca 1357261 ttggaaaagg ttaaatacta tttaaatcat gatagcgaga gaaaaaagat tcagataaac 1357321 ggtaaaaagg ctgtaaagaa tgattcctat cggcatagag ccgagagaat gcttgaggtg 1357381 ctaaaaagca gaggaatcat aagaaactta ggggaaacca ttcattatgt agatgttctc 1357441 aaagaaaaat acgtgatcca tcatgttact cccggtgaaa cattatcaat aattgccagt 1357501 aagtataatg tttccctgca gcaactcatg gagcttaatc atttcaaatc agatcaaata 1357561 tatgctggac aaatcattaa gattagagag aaactgttta gaaatattaa taacaaatta 1357621 ttctaaagga gagtaatatg aatgaagggg aaaataccta aaataagaaa tcaagcgaat 1357681 aaagtaaaaa gaacgcctcg ttatatggaa tttcccgtga catacgaagt atatcatgtg 1357741 gaatccggcg atacattatg gacgattgcc aaatcctttg aaattccggt acaacaactt 1357801 atgaatctta ataagctttc ttcagataga atttatcctg gacaaattat aaagataaga 1357861 gaaagataat ctttgaggtt tcggaagcga atcaaattga aatgacaatc ctcatttttt 1357921 tatttgtggg gaacttgata tttttgggga tgaaggggtt atgagatgtt tcaaatgagc 1357981 tattactatt ctggattagg atgggacttt attcaacacg ttgatcaaac gaacggagta 1358041 ttaaatgttg tgtctcctga ttttttctat atcagaaaag atggatcatt acttctccgt 1358101 tcagctaatc ccgatgtgat taaagctctt catagaagaa aattaaaagt agttcctttt 1358161 ctaagcaatc attgggatca ggatttggga cgatttgcat taatgaaccg agttctttta 1358221 gctaaacaaa tttctcatgc aatagaagaa ctggatttgg atggagttaa tatcgatata 1358281 gaaaacctta cagaaaaaga tcggaatcta tttacagatt ttattagatt agtaaggaaa 1358341 agtattccta gacataaaga agtatcagtt gcagtggcgg caaatccttt tggctggacg 1358401 aagggctggc acggatcata tgattacgag tatttagcta aatatgcaga ttatcttatg 1358461 gttatggcct atgatgaaag ccgccttgct gggcctactg caagtgtagg atgggtggaa 1358521 aagtccattc aatatgttct gacccaaaaa atctctcctc aaaaactagt tttaggattg 1358581 ccattctatg gccgctgctg gatggaaggc caatctgcct ctcaagccat tcccctttac 1358641 cttgttgtta gtaaaaaggc atagcgggac aattattttt gacaccaaga gtcaatctcc 1358701 aaaagctatt tttactgtca atcacgataa aaaggggccg ttgccttcgg gaacatatac 1358761 attatggttt gaaaatgaac agtcactcag agcaaaaata aaactcgctc aaaaatataa 1358821 tctgaaaggt cttggcagct ggagtcttgg acaagaagat gcgtcagtct ggaatacagt 1358881 gtttaaaaat atataatgat ttatagttca gaacaaaatt cgaagataat tgcaatgaat 1358941 ctctaaatgg acatactgaa aggagtttat tacgagtgcg ggtaaaacag tgagggcatt 1359001 ccataggccc ttctcccaaa atgttctaca cgaggcatta cattgggctt gaaatacaca 1359061 ttcaaactta tgttatagta cgcattttac ggatgtgttg aatttattct gcttccatga 1359121 tttaatcata cacatgctac ttgatagcag ggttatcgca tttcattcag aattgttcag 1359181 gatcgatatg gaagcgcacg actaactaga actttaaaag catacactca tatacttcct 1359241 gaatggatgc tggtttatct aaaaaacatg atgagaattg attgtacgca tggtgaagca 1359301 tgacttgttg ataatcgacc atatggtttc tccttagaaa tgagggggtt tttacataaa 1359361 aaagacgagc gaatccgggg ggaattccac tcgccgcttt ctaatgaaaa gacgggatgc 1359421 tggatggcag ctcgtctgtt ttattataat ttaacgaacg tatgtttgta aaggtgtctt 1359481 ttcgaatgaa ttggttcata taaccgttaa gaacagattc attgtaaaca ttcgctaagg 1359541 tatgctaaga tgcatggact ataaaggagt gatatgaagt gaagacattg cggttaaaca 1359601 atgtaacgtt agaaatggct gcatatcaag aggagagcga gccgaagcga aaaattgcat 1359661 ttaccttaaa cgttacgagt gagacttacc atgatatcgc tgtcctgttg tatgaaaaaa 1359721 cgtttaatgt cgaggttccg gaacgcgatc ttgccttccg gggggaaatg acaaattatt 1359781 caacatcatt gaccaacctg tacgaaccag gggccgtcag cgagttctat atagaaataa 1359841 cggaaataga caaaaacgcc gattcatgat cggtgttttt tatgtaaaaa agctgccggc 1359901 cggcagcttt tgagaaagcg aatttcatat gtaaggtgtt aaattgtccg tcttgcagtt 1359961 ttttgaataa atgtggaaat aaggaggttt taataggagt ctctgatgat cttataattt 1360021 ttatgattaa caactgtcaa tgaatctaac tcaagatccc gatagttatc catgatcgtc 1360081 acatcaacga taacagaatt ctcatttact ttttcaacaa caccggttaa tccgttttta 1360141 aattcaatga cattcccaac cttagcgatt ttcacaagct tcctctcctt taaacataat 1360201 aatgcctttt gaaagtattt tgcagtattt tcattgagaa gtaaagcgat aaggagtttt 1360261 atctccctta tgaattgttc tgtcgctata aagatgatat attgattttc gtcaatagaa 1360321 agaaaagggg ggaatttttg ttgcgtcccg aagaaataac agaaatgatt gaacagctgc 1360381 gcaccggcgc cataaacgaa ctgagagtcc agaaagagca ttttcttgat ttcagggccg 1360441 tgttatctaa acaagatgat tttaaacatt tccgaggaat tgcccagcaa ggcggagatg 1360501 ttatctttca atacttagaa cagccaagaa gctgaaggtt tctcatacgt gagaagcctt 1360561 tttatcatat atgacagaac acaagccttt tattacagct gtctgtaaca ggtgtaaata 1360621 aaatgtaaag taccaaagat ggataaacat gttttaattt aacaatattt atagaatttc 1360681 agactgtttt tttgccatta agcagtgagt catcctcttt attccatcct gatacctcct 1360741 tgggagagtt ggaaaatctt tttccgtgaa aatgaatgga tctcttgtta aggttatgaa 1360801 gtgttttttg gagcacttta aggaggaaac tgtatgacaa cgaaattcac tgctctggct 1360861 gtttttcttc tttgtttcat gcctgcagcc aaaattgagc atacacaagc ttcactactg 1360921 agcgcaaaga agacaaaaca tgaagaagcg aaatggctta cacatataga tcgaaatacg 1360981 aatgaatctt tcccttcact gtctgctgat aaagacaaga aaataaaacc gattaagcta 1361041 tcagcacaca ctgaaaagaa agagaaagat aaaccggaca aaacaaatga tgagaaagaa 1361101 acatatacac agtctgaaaa agagttgctg tcccgtctcg ttcacgcaga ggccaaagga 1361161 gaatcatata aaggcaaggt cgctgtagca agcgttgtac tgaacaggac ggagaaaaaa 1361221 ggttttcctg atacgataag aggagttatt tatcagaaaa acgcctttga accggtcgca 1361281 aacgggagca ttaaccaaaa gcctgataaa gaatcgattg aagctgccga agaagcgctg 1361341 tcctcaaaaa atagagaaac agatgccata ttcttttata atccgaaaac agcgtcagat 1361401 aattggattc gttcaagaaa aatcgtagaa aaaatcggca gacacgtttt tgccgtctaa 1361461 gcatagaaga gacaatttgt ctcagctgtg ctttttttca tataaagagt aaaaataaaa 1361521 taatttttga acttgtctca tatgatgttg gtagtacaag agacaaggag agacatcatg 1361581 aatcgatttg tgaaagggat cattctttta tccattgccg cctttttcgc tgaatgcctt 1361641 gaatttgtcg tcaatatgat tttggcgcgg gagcttggcg agcatgggat ggggctttac 1361701 atgagtattt tgcccacgat ctttttaatt attgtcatcg cgagcctgga actgccgata 1361761 tccatttcta aattcattgc cgagtcaaat cctaagcttc atgaaagcat gctgaggcac 1361821 gctttcagaa tgacagccat ttttactgct ttttctactg ccgccgctag tattgcgctt 1361881 ccgtttattc cggtatttga tacataccac ccgtttatta aagggattgt catcggctta 1361941 attcctgttg tcgcctttac ttcaatcgcc aggggctact ttatgggtgt gcagaaaatg 1362001 gggaagatcg caattgccaa tgtgctgaaa aaaatcatcc agctcttgtg cttattcctc 1362061 ttttttcaat ggtactcatt tgaattggac atggctgtgc tgatttcctt gtttgttcta 1362121 gtcgtgagtg atgtggtcgt gcttgtttat ttatattcac aatttatcat ggcaaggcgg 1362181 gcgttatccg gccagcagca cattcatttg cgcggaaagg atgtaaggaa aagactgctt 1362241 gctgtttcaa ttcctacaac aggactgcgt atttttcatg cggttgtcaa tgcaattgaa 1362301 ccctttttag taaaaggagc tcttttggct gcgggcgttg ccgggacagc ggcgatcgat 1362361 caatacggaa tgctggcagg agtggctgtg acgatagggt cgttccctgc ttttattgcc 1362421 cattcgttaa tggtcgtcat gataccgagt atttcggaag cttatgcact ttctcagtat 1362481 gacatcgtgt taaaaaggct gaagcagtcg attttcatta cattaggtta cggtatacct 1362541 gccgtctggg tcatgttcca gtttgcggga cctctcacgc atttgttttt tcactctcct 1362601 gaagcgcagt attacttgca gctgttgtgg ccttactttc tctttcatct gtttgtcatg 1362661 ccgctgcagg cgtgcttaat cgggatgggt tttgtgaaag aggcttttta tcacaatgta 1362721 tggagccata tcgttgcgct aagtatgatg tatgtactgg gatcaatgga gaatctgcaa 1362781 atgctcggga ttatccttgg aatgaacact ggcatgattc ttttgacgag cctgcactat 1362841 gccacgatct gcaaagcatt gaaggtatct gtatttctta cgggagggac cagaacgccg 1362901 cgaattgaag gatgataaag gaacagcagg ggcaagctaa ttgaaaagca tgaaaggaag 1362961 attccatgtt gacgaagcgc ttgcttacta tatacattat gttattaggg ttgattgcat 1363021 ggtttccagg tgcggcacaa gctgaggaaa aacagcctgc tgttcccgct gtttttctta 1363081 tgaaaacgat agaaggggag gacatctcga ttccgaataa agggcaaaaa acaattctcc 1363141 atttttggac gtcatggtgc ccgccctgca aaaaggagct tccacagttt caatcgtttt 1363201 atgatgccca tccatccgac agtgtaaagc tggtaacggt gaatttagtg aattcggaac 1363261 aaaatcagca agtcgttgaa gactttatta aagcaaacaa gctgacgttt ccgattgtcc 1363321 ttgactcaaa aggggaattg atgaaggagt atcatatcat cacgatccca acatcatttt 1363381 tgctgaatga aaagggagaa attgaaaaaa caaaaattgg cccgatgaca gcggaacaac 1363441 tgaaggaatg gacggaagaa tagctgagag catagactct cagctttttt catatagaga 1363501 agaagtgaat aaacattaat gataattatt atcaaaaaga aattaaaata attataattg 1363561 aaattctctt cgtgcgtgct ataataaagg aagacatcaa gaaataactg acgataaagc 1363621 tgccttttgg gcagcgattt tgtttttata agagaaatga agatgattta cgttctcaat 1363681 tagagaggag aattcgatat gaatgaacaa gttatcgttc aacgcgaccc gcatgagcca 1363741 ttgaaaacag acaagaggga aaaaaactgg gcacagcacg cggagcttat tgcagcactt 1363801 gtatcaggcg ctcttatttt ggcaggctgg ctcttatccg gatatcaggt attatccata 1363861 atacttttct tgctggcttt tgtgatcggc ggatttgcta aagcgaagga aggaatcgaa 1363921 gaaacactcg aatccaaaac gctgaatgta gaacttttaa tgattttcgc tgccattggt 1363981 tccgccttga tcggatactg ggcagagggt gctattttaa tatttatttt ttccttaagc 1364041 ggagctttag aaacatacac gatgaataaa agcagcagag atttaacgtc tttaatgcag 1364101 cttgagcctg aagaagcgac attgatggtc aatggtgaaa ccaaaagagt tccggtttca 1364161 gacttgcagg ccggtgatat gattgtgatc aaacctggag aacgcgtagc ggcagacggt 1364221 atcattgaat cgggctcgac aagtcttgac gagtcggctt taacaggtga atcaatgcct 1364281 gtagaaaaaa acacaggcga cactgtattc acaggaacgg tgaatcgcaa tggctccttg 1364341 acagtccgtg tcacgaaagc aaatgaagat tcgttattca gaaaaattat caaactggtt 1364401 gaatcagcgc aaaatagtgt ttcacccgcg caggctttca tcgaacgatt tgaaaatgct 1364461 tatgtgaaag gtgtgctaat tgcggtggcg ctccttttat tcgtcccgca ctttgcgctg 1364521 ggctggagct ggagtgaaac cttctaccgc gcaatggtgt ttatggttgt cgcgtcacct 1364581 tgtgcgcttg tcgcctctat tatgccggcg gcgctgtccc tgatttcaaa tggcgcccgc 1364641 aacggtatgc ttgtgaaagg aagcgtcttt cttgaacagc tgggctcagt gcaaatgatc 1364701 gcctttgata aaaccggaac tgtaacaaaa ggccagcctg ccgtagagac gatcagaata 1364761 gcagaaggat tcagtgaagc ggaagttctt gaggctgtct atgccatcga aacgcaatca 1364821 agccatccgc tcgcccaagc cataacggcg tacgctgaaa gccgcggcgt gaatcagtcc 1364881 ggctacatat ctatagaaga aacctcaggg tttggcgtta tggcagaagt gtcgggtgcg 1364941 aaatggaagg tcggtaaagc aggttttatc ggcgaggaaa tggcagcaca atttatgaaa 1365001 caaacagcat cagatgtcat tcaaagcggt catacaattg tatttgtgaa aaaggatgat 1365061 caaatagcag gctgtatcgc actgaaggac caaatcaggc ctgaagcaaa agaggtcatg 1365121 gaagaactga accgacttgg gattaaaacg gccatgctga caggagatca cgaagacacg 1365181 gctcaagcga ttgccaagga agccggcatg acaactgtcg tggcagaatg cctgcctgac 1365241 caaaaagtga atgaaatcaa acggttaaaa gaagaattcg gaacgattgc aatggtgggt 1365301 gacggaatca atgatgcgcc ggcactcaaa gcagcggatg tcggcattgc gatgggcggc 1365361 ggaacagatg tagcacttga gaccgctgat atggtcctca tgaaaaacga tttgaaaaag 1365421 ctcgtaaaca tgtgccgctt gtctcggaaa atgaacagga tcatcaaaca aaatatcgtg 1365481 ttttctctag ctgtaatctg cctgctgatt tgtgcaaact ttttgcaggc gatggaattg 1365541 ccatttggcg tgattggtca tgagggcagc acgattttag tcatactaaa cggtttaaga 1365601 ctcctaaaat aaaaccagca gcctaatcag gctgctggct ttttatgtat caagctttcc 1365661 cttcattttt gtctttatca gatcttttca taactaggat gagagcgagg gtgcagcaaa 1365721 ggaaacccgc tgcacagcct atgatagagc tgtaataata aaagcccacc atcttcatcc 1365781 cgataaaagg agcggaaatt cccaaaaccg ttaagagcat aactgctttt cgtctgaaaa 1365841 aattcatcag caaacggaac aacccccctg cgattgaacg ttactgtcag tatacaggaa 1365901 gaggagcagg aaataaaatg cattagaaaa tgaaggcgtc gtgaaaggca aacaccggta 1365961 aaacctgtta caatggaaga cagaacaatg cattgcaaat ggcagggagg aacaagaagt 1366021 gaatagaata caacgcgtct cttcatggct gaaggaagcg gggcatactg ccgcatttat 1366081 tcatacgaaa gaaaatgttt tttacttaac cggtttttac acagagccgc atgaaagatt 1366141 aatggggtta tttatttttc aagaagagga gcctttcttt gtttgtccag gaatggaagc 1366201 aggacaggcc cgcaacgcag gctggaatca tgaaatcatt ggctatgcgg atcacgaaaa 1366261 tccgtgggag ctgatagaga aggctttgaa aaagcgaaat atcagcatac atatgcttgc 1366321 ggtagaaaag gattcaatct cgctgtcacg tgcagaacag ctgaagcatg cgacgggcgg 1366381 ggctcaattt gtttcagcag aagaaacact caatcaattt cgcctgatta aagatgacaa 1366441 tgagattcgt ttgctgaaag aggcggcaaa gcttgcagat tacggtgttg aagtcggcac 1366501 agccgctttg cgtgaaggca tcagtgaagt ggaagtgctc gctcaaattg agtatgagct 1366561 gaagaaaaaa ggaattcagg gcatgtcttt ctctacaatg gttttattcg gagaaaaatc 1366621 tggccagcct catggaaatc ctggtacagc cacgttgaag aaaggtgatt ttgttttatt 1366681 tgatctcggt gttattcttg atggctattg ctctgatatt acaagaacgt ttgcatacaa 1366741 aaccatcaat ccgaagcagg aggccattta cgagactgtg cttcaagcgg aaaaagccgc 1366801 gattgaggca agcaaacccg gtgtgagaat cggagatctg gatttaactg cccgcggaat 1366861 cattgaaaaa gcgggatatg gtgattattt tcctcaccgg cttgggcatg gactcggaat 1366921 ttcagtccat gagtatccat caatgagcca ggccaacgat acactgctgc aggaaggcat 1366981 ggtctacacg atcgaaccgg ggatttatgt gccagagatc ggcggcgtac gcattgagga 1367041 tgacgttcac gtaacaaagg acggagcagt tgctctgacc caatatccaa aggatttgat 1367101 catactgtaa tagaaataaa aaaggacttt gttctcgaca tcgtcctttt ttatctgcat 1367161 taaataaaaa aatcatcaaa tgttcgaaag ggtttaattt catgtttttg gttgagaggt 1367221 tttacagcaa gacagctgcc accgagaaca gtgagacata acccaattaa aatgaagaaa 1367281 cccatgtgat cttctccttt cagctaaaaa cacaaaaaga tatctggtac gtccatatca 1367341 tattgtatga aacgcattcc agatcaaggg gatttagaaa gaagggaatc tatggctaat 1367401 attaaagaca ttgcagagaa agccggtgtc tctgttacaa cggtttcccg agtcataaac 1367461 aatcatccat acgtcagtga agacaaacga aaaagagtgt ttgaggcaat ggaatcattg 1367521 gagtacacga gaaatattca cgctgtacat ttgtcgaaag gattttcaaa catgattggt 1367581 gttgtcttgc cgacggttaa tctgccatat tttgcagagc tgattgcagg aatagccgac 1367641 gcagccgcgg aatccggggt tcacctctct ttattccaaa caaactatga agtacaaaaa 1367701 gaaatctttg cgctgtccca attaaagcag cgccaggttg acggcctgat tttttgctca 1367761 aaggcgcttg ctgatgagaa actcatggaa tgggagggcc cgattttgct ttgccagaat 1367821 tcagataatg cccgcttccc aaccatcagc attcctcacc aagaagcatt tcggaacggc 1367881 ttggactatt taattgccaa agggcacaaa aaaatagcca tctgtttggc aagaaaaaaa 1367941 ggcatgaaca gccattttcg aatcaaagcc tacaaagagg cattggaaga gatcggcgag 1368001 gcatttcgtg aagactgggt aattgagaaa gcgattacaa tcaatgatgg gaaggcgctt 1368061 tttcataaat ggaatacgtg gaaggaaaag ccgacggcta tttttgttgc caatgaccaa 1368121 gtctcagcag ggctttttct tgaagcaaag aaccagcggg tgtcagtacc ggatgagctt 1368181 gcaatcttaa gcgttgataa ccacgaaatc agccaagcgc ttggaatcac aacgatcgat 1368241 attcagacaa gggaaatggg aaagcaggca tttgccatat tggaaaaaag aattcaagga 1368301 cagccgattg aaaggaaagt tctggattac cgtctcatcg aaagatcgac tgtttagtga 1368361 atgcattgaa aaaaggtttg acgtgcattc tgttcgttat gtacgatatg aggtattgaa 1368421 tgacaaagga gctgaggatc gtgaatgggt ccttcacagt gaaaaaggta ctgaataata 1368481 acgtattaat tgcttctcat cataaataca gcgaagtcgt tttaatcgga aaaggtattg 1368541 gtttcggaaa aaaacaagat gatgtcattg aagataaagg ctacgataaa atgttcattt 1368601 taaaagacga gaaggaacaa aagcagttta aaaagctcct tgactatgtt gatgaaaagc 1368661 tcgttgatat ttcaaacgat gtcatctatc acataagcaa taggacgaat cactcattaa 1368721 atgaacatat tcacattgcg ttgacagacc atatcgcatt tgcgatcaaa aggcagcagc 1368781 agggatttga tatgaaaaat ccatttctaa tggagactca gtcactatat cctgaggagt 1368841 accaaattgc caaagaagtc atagatatga tcaatgaaaa agcgggactc tgccttccgg 1368901 aaggggagat tggttttatc gctctgcata tccattcagc gttgacaaac cgtccgctgt 1368961 ccgaggtcaa tcagcactct cagctcatgg cgcagcttgt cgaggtgatt gaagactcat 1369021 ttcaaatgaa agtaaataag gaaagtgtca actatttgcg gctgatcagg catatcagat 1369081 ttacaataga aagaattaaa aaagaagaac cgactaaaga accagaaaaa ttaatgttgt 1369141 tattgaaaaa tgaatatccg ctatgctaca atacagcttg gaaattgatt aaaatcttgc 1369201 agcaaacatt gaagaaacca gttcatgagg cggaagcggt ttatctgacg cttcatctgt 1369261 accgattaac caataaaatt tcataaattc agtttatcct tataacgtgt tactgattcg 1369321 atcaggcatg agtgattgag ggaaaaaaac gggaagttca ttctcgttct tttgcgcacc 1369381 caattttgct catgcctttt tgttgtgtaa aagggcaaat gtaaacggtt aaactggaag 1369441 acttacgcct gtgaattcgt tgtcatgatt tttagctgta aggtcagact agtaaaaaga 1369501 ggaggtcaat tcttatgttt aaagcattat tcggcgttct tcaaaaaatt gggcgtgcgc 1369561 ttatgcttcc agttgcgatc cttccggctg cgggtatttt gcttgcgatc gggaatgcga 1369621 tgcaaaataa ggacatgatt caggtcctgc atttcttgag caatgacaat gttcagcttg 1369681 tagcaggtgt gatggaaagt gctgggcaga ttgttttcga taaccttccg cttcttttcg 1369741 cagtaggtgt agccatcggg cttgccaatg gtgatggagt tgcagggatt gcagcaatta 1369801 tcggttatct tgtaatgaat gtatccatga gtgcggttct tcttgcaaac ggaaccattc 1369861 cttcggattc agttgaaaga gccaagttct ttacggaaaa ccatcctgca tatgtaaaca 1369921 tgcttggtat acctaccttg gcgacagggg tgttcggcgg tattatcgtc ggtgtgttag 1369981 ctgcattatt gtttaacaga ttttacacaa ttgaactgcc gcaatacctt ggtttctttg 1370041 cgggtaaacg tttcgttcca attgttacgt caatttctgc actgattctg ggtcttatta 1370101 tgttagtgat ctggcctcca atccagcatg gattgaatgc cttttcaaca ggattagtgg 1370161 aagcgaatcc aacccttgct gcatttatct tcggggtgat tgaacgttcg cttatcccat 1370221 tcggattgca ccatattttc tattcaccgt tctggtatga attcttcagc tataagagtg 1370281 cagcaggaga aatcatccgc ggggatcagc gtatctttat ggcgcagatt aaagacggcg 1370341 tacagttaac ggcaggtacg ttcatgacag gtaaatatcc atttatgatg ttcggtctgc 1370401 ctgctgcggc gcttgccatt tatcatgaag caaaaccgca aaacaaaaaa ctcgttgcag 1370461 gtattatggg ttcagcggcc ttgacatctt tcttaacggg gatcacagag ccattggaat 1370521 tttctttctt attcgttgct ccagtcctgt ttgcgattca ctgtttgttt gcgggacttt 1370581 cattcatggt catgcagctg ttgaatgtta agattggtat gacattctcc ggcggtttaa 1370641 ttgactactt cctattcggt attttaccaa accggacggc atggtggctt gtcatccctg 1370701 tcggcttagg gttagcggtc atttactact ttggattccg atttgccatc cgcaaattta 1370761 atctgaaaac acctggacgc gaggatgctg cggaagaaac agcagcacct gggaaaacag 1370821 gtgaagcagg agatcttcct tatgagattc tgcaggcaat gggtgaccag gaaaacatca 1370881 aacaccttga tgcttgtatc actcgtctgc gtgtgactgt aaacgatcag aaaaaggttg 1370941 ataaagaccg tctgaaacag cttggcgctt ccggagtgct ggaagtcggc aacaacattc 1371001 aggctatttt cggaccgcgt tctgacgggt taaaaacaca aatgcaagac attattgcgg 1371061 gacgcaagcc tagacctgag ccgaaaacat ctgctcaaga ggaagtaggc cagcaggttg 1371121 aggaagtgat tgcagaaccg ctgcaaaatg aaatcggcga ggaagttttc gtttctccga 1371181 ttaccgggga aattcaccca attacggatg ttcctgacca agtcttctca gggaaaatga 1371241 tgggtgacgg ttttgcgatt ctcccttctg aaggaattgt cgtatcaccg gttcgcggaa 1371301 aaattctcaa tgtgttcccg acaaaacatg cgatcggcct gcaatccgac ggcggaagag 1371361 aaattttaat ccactttggt attgataccg tcagcctgaa gggcgaagga tttacgtctt 1371421 tcgtatcaga aggagaccgc gttgagcctg gacaaaaact tcttgaagtt gatctggatg 1371481 cagtcaaacc gaatgtacca tctctcatga caccgattgt atttacaaac cttgctgaag 1371541 gagaaacagt cagcattaaa gcaagcggtt cagtcaacag agaacaagaa gatattgtga 1371601 agattgaaaa ataagggtgt tagtacgccg tgcttgtcag atgacaagta cggttgtatg 1371661 atataatatt gtgaagtaat aaagctttaa gttaaaagga gaatgataaa aatggcacaa 1371721 aaaacattta aagtaactgc agattctgga atccatgctc gtcctgcgac agttcttgta 1371781 caaactgcta gcaaatacga cgctgacgtt aatttagaat ataacggcaa aacagttaac 1371841 cttaaatcta ttatgggtgt tatgtcttta ggtatcgcta aaggcgctga gatcacaatc 1371901 tctgcttccg gagctgacga aaacgatgct cttaacgctt tagaagaaac aatgaaaagc 1371961 gaaggactcg gcgagtaatg caagaattaa aagggattgg tgcttcagcc ggcatcgcga 1372021 ttgcaaaagc gtaccggctt gaagagccag atttaacggt tgaaaagaaa aacatctctg 1372081 attctgaagc ggaagtaagc cgttttgatg aagcgattgc acgttcaaaa gaagagctcg 1372141 aaaaaatcaa agagcacgct ttgaaagaac tgggtcagga taaagctgat attttttctg 1372201 ctcacctttt agttctcagt gaccctgagc ttctgaaccc tgtgaaagaa aaaatcagca 1372261 ctgattcagt gaacgctgaa ttcgctttaa aagaaacgtc ttctatgttc gttactatgt 1372321 ttgaatctat ggacaacgaa tatatgaaag agcgtgcggc agatatccgc gatgtaacaa 1372381 aacgcgtaac cggccacctg cttggcgtcg aaattccaaa cccaagcatg atctcagaag 1372441 aggttattat tgtagctgaa gacttaacac cgtctgacac agctcaatta aaccgtgagt 1372501 tcgtaaaagg attcactact gatatcggcg gacgcacatc tcactctgcc atcatggcac 1372561 gttctcttga gattccagca gttgttggaa cgaaagctgc tacaggcacg atccaaaacg 1372621 gcgtgactgt tatcgttgac ggtatcaatg gcgatgtcat tattgaccca tctgcggaaa 1372681 ctgtaaaaga gtatgaagaa aaacataatg cttatttggc tcaaaaagct gagtgggcga 1372741 agcttgtcaa tgaaccgact gtctcaaaag acggacatca tgtagagctt gcagcgaaca 1372801 tcggtactcc tgatgatgta aaaggtgttc ttgaaaacgg cggagaagca gttggccttt 1372861 accgtacaga attcctttac atgggaagag atcagctgcc tacagaagat gagcagtttg 1372921 atgcttacaa aacggttctt gagcgtatgg aaggaaaatc agtcgtcgtg cggacacttg 1372981 atatcggcgg agacaaagag cttccttacc tgcagcttcc taaagaaatg aacccgttcc 1373041 tgggatatag agcgattcgt ctttgccttg aagagcaaga aatcttcaga acacagcttc 1373101 gcgcgctgct tcgtgcaagt acatacggaa acttgaaaat catgttccct atgattgcga 1373161 cagttaacga attcaaagaa gcaaaagcga tccttcttga agagaaagaa aagctcgtaa 1373221 aagcgggaca ggctgtatct gacgatattg aagtcggaat gatggttgag attccgtcaa 1373281 ctgcagtcat cgctgatcag tttgctaaag aggttgattt cttcagtatc ggaacaaacg 1373341 atttgattca atacacaatg gcagctgacc gtatgaatga acgtgtatct tacctgtatc 1373401 agccatacaa cccggcaatc cttcgcttaa ttacactggt aattgaagca gcacacaaag 1373461 aaggaaaatg ggttggcatg tgcggagaaa tggcaggaga cgagattgcg attccgatcc 1373521 ttctcggctt aggcttagat gagttctcaa tgagcgcaac gtctatcctt ccggcaagaa 1373581 cacaaatcag caaattgtct aaacaagaag ctgagtcatt caaagagaaa atcttatcta 1373641 tgagcacgac agaagaagtt gtcgcgttcg taaaagaaac attcaagtaa tgtacaaaaa 1373701 ccagacggcc tccggcctgt ctggtttttt tcataagtaa gggtatagaa ggacacaata 1373761 acatggctag gagggatagt atgtcaaacc aatttaacgc aggagatact gtttatgtga 1373821 tctacagaaa tccgcacgcc gccaatgtag cccacataaa ggaagccgaa attgtgcacc 1373881 atccatacca tgaaggcgag ctttccctgt ttatttatga aacctatcat ccattcgcag 1373941 aggacgatgc tgtgtttgca agctatgaag aagctaaatc gctttacaaa gaactgtttg 1374001 atattgatcc gtatgagtaa caaggaaatc attacaactc atatcctttc cgcctagtga 1374061 gaaaagtaac gttagtaaag gaaaaggatg tggcatcatg cagaacccat ttgttccgca 1374121 gcttgtgtat atagaaccga gggcgctgga atatccgctg ggccaagaat tacaagataa 1374181 atttgagaat atgggtattg aaatcagaga aacgacatcc cacaatcagg tgcgtaatat 1374241 ccctgggaaa aatcatcttc agcaatatcg caatgcgaaa tcaactttag ttatcggtgt 1374301 ccggaaaaca ttaaagtttg attcatccaa accctcggcc gaatatgcca ttccgtttgc 1374361 aacaggctgc atggggcatt gtcattactg ctacctgcaa acaaccatgg gatcaaagcc 1374421 gtatatcaga acttatgtaa acgtcgaaga gattttagat caggcagata agtatatgaa 1374481 ggagcgcgca ccagagttca caaggttcga agcatcatgt acgtcagaca ttgtaggaat 1374541 tgatcatctg acacacacgc tgaagcgcgc cattgaacat tttggccaaa gtgatctcgg 1374601 aaagctccga tttgtaacga aatttcatca tgtcgatcac ctattagacg caaagcataa 1374661 cgggaaaacg agattcagat tcagtattaa tgccgactat gtgattaaaa actttgagcc 1374721 gggaacttca cctcttgata agcggataga agcggcagta aaagttgcaa aagcaggcta 1374781 cccgctaggc tttattgttg ctccgattta tattcatgaa ggctgggaag aaggatacag 1374841 acatctgttt gaaaagctag atgctgcttt gccgcaggac gttagacatg acattacgtt 1374901 tgaattaatt caacaccgtt ttacaaaacc ggccaaacga gtgatagaga aaaattatcc 1374961 gaagacgaag ctcgaattag atgaagaaaa gcgccgttat aaatggggcc gttacgggat 1375021 cggaaaatat atttatcaga aagatgaaga gcatgcactt cgagaggcac ttgaatccta 1375081 tattgatacc tttttcccta acgcaaaaat tgaatatttc acttaaacgg gctgttgtga 1375141 tcaacagctc gcttttttat aaaaaacatt tttccattcc atcaaaacgc cgtaattcaa 1375201 tgattcttta tcctccaaat aattgctgac tacacgaata ggtgaacgcc cgcaacggag 1375261 gagaaaggac agcacagggt cgtttttcct gccttccatc acatcttcaa cgtactgaac 1375321 agcgctgatc tcgtgtgcgt atttataata caaaggaatg cggccgccgc cgagaaggcg 1375381 ttccagtctt ttatcaacag tcagctcata catcgtattc atcagccatt ttccgattcc 1375441 aagctttcga taatgaggag aaacagaaat atccactaca tataaagtat ttccatgagg 1375501 ttcatgattt ttaatcgatc cgttgtcagt tgcttgtgcc catgtatgat caggagaatc 1375561 aggctcaaat tgtacaataa gagcagtcat ggaaccgata attctgccat tgatgagcgc 1375621 gcataaagcg ccttccggaa aggttttgat atggctggca agctggtcct ctgaccacag 1375681 caattcctgg ggaaacggag gagggaaaca ttcttcttga agagaaatca gcctctcgat 1375741 gtcagtctca gtgtagtttc taatggtcag agcctcaaat tttctgccgt catgcacata 1375801 catttgtttt agtatgatca tcactctcct tatgttgttt cattataacg aagattgaat 1375861 tttcagtaaa tatattccga ttttcttata atttattttt tgattattca tttttcaaac 1375921 gaaagggccg atatagaaat taggagggga ttggtttgtt taaaaaactt cacatgaaga 1375981 ttgctgtttt tgtttcgatt atgttaatca tcacagttgt tctcttaatg ctgtcttctt 1376041 atttgacgct aaaaccgatg attacagagg atgggaaaaa tacaactcaa aacgtgacgc 1376101 agtcacttga acaaaatatt gaattgcaat taaagagtta tgccatttcg ttatcaagat 1376161 tggctaatgg ggaattaacg catacatttg taacgaaacc aagtaaagaa gcttctcggc 1376221 tgtttcacga tgacattaag caaatcaaag acaacgatga ttatgttgcg atggcttaca 1376281 taggcaccgc aaaaaaagaa atgtttacat atccaaaagc ggatttcgct gaggattacg 1376341 atccaacatc aagaccatgg tataagcttg cagctgaaac cccggatcaa gttgtttgga 1376401 cggaacctta taaagatgtc gtgacaggag acatgattgt tactgcatcg aaagcgatct 1376461 tagacaggca aaaagtgata ggggttgcca gctatgactt gaaactctct gctatccaga 1376521 gtatggtcaa taaacaaaag gtgccttaca aaggatttgc ctttttagct gatgcgagcg 1376581 gcaatctttt agcccatccg tcaaatcaag gaaaaaatat atcaaaggat caaacactgc 1376641 aaaccatcgc atccgagaaa aaagggatac aagatgtgaa tgggaaaatg gttgtgtacc 1376701 aaacgattgg cgagacaggc tggaaggtcg gaacgcaatt tgataccgat caattaatgt 1376761 ggatttcaga taaaatgaat cgggccaatc tttggatatc attgattgcg cttatcataa 1376821 caattattct cagctacttc ctggccaaaa cgataaccgg tccgatacag cagctgatcg 1376881 taaaaacgaa agctgtttcc gcaggcgatt taacagtgcg cgcggaatca aaatctaagg 1376941 atgaagtcgg tattttaaca agagatttca atctgatggt tgaaaatatg aaggaaatgg 1377001 ttgagcaagt gagactctct tcagggaaag tatctgacac ctctgaacaa ctaacggctg 1377061 tggctgccga aactaatgaa acaagcggac aaattgcaaa agcgattgaa gaagtagccg 1377121 caggggcatc ggaacaggct tctgaagttg aaaccattaa tgaaaaatcg gaaagcctgt 1377181 caacgaaaat caggcaaatc gctgaggagg caggcggaat taaagaacgc tcaaaatcgt 1377241 ccgaggatgc aagctataaa ggacttgacg cgctcggcca gctgctgatg aaatcaaacg 1377301 aagccaatat ggaaacgaaa aaggttgaaa cgatgctgct ggatttggaa aatcaaacta 1377361 agaatattga agaagtcgtt acagcgattt caaacatatc tgatcaaacc aacttgcttg 1377421 ccttaaatgc cagtattgag gcagccagag ccggagaaag cgggcgcggt tttgccgtcg 1377481 tagccgatga agtgcggaag ttagctgagc aatcagccct ttctacaaag catatcagcg 1377541 agactgtgaa gcttatccag cttgagacaa aagaggcctc tcacgcgatg gttgaggcaa 1377601 gcagaatgaa tgatgaacaa aacagtgcaa ttcacgaaac tggagaggta ttaaatacga 1377661 taactgcaga aatgcagtca ctggtacaag gtattgatca catttacgcg gaaattcaaa 1377721 gaatgagtga agaacagctt gcgatttctg aagccattca aagcatttca gccatatcac 1377781 aggaatcagc tgccgcagca gaggaagtga acgcatcaac cgatgaacag cttgtcaccc 1377841 ttgataaagt caaacactca acggaaacac taaaacatgc aagccaagag cttatgaaca 1377901 caattgcaaa attcacattg taatccaatt acatccccaa acatcatttg ttttggggat 1377961 tttttatttt ataagatgaa tagatatggt agtctagaaa atgaaggaaa aatgataaat 1378021 tttaactaaa atctaaacga aacatctggg aggaatgacc ttgaaaaaaa caattggttt 1378081 tatcggtctt ggagtaatgg gaaaaagcat ggcatcacat attctcaatg acggccatcc 1378141 tgtattggtg tacacccgga caaaagaaaa agcagaaagc atacttcaaa aaggcgcgat 1378201 ctggaaagat acggtcaaag atctttcgaa agaagcggat gttatcatca caatggtcgg 1378261 ctatcccagt gatgttgaag aagtgtattt cggaagcaat ggaattattg aaaacgcaaa 1378321 agaaggtgca tatcttattg atatgacgac atctaagcct tcgcttgcga agaagattgc 1378381 tgaagcggcc aaagaaaaag cattgttcgc tttagacgct cctgtttccg gtggagacat 1378441 cggtgcacaa aacggaacac tcgcgattat ggtcggtgga gaaaaagaag cttttgaagc 1378501 ctgcatgccg attttctctt taatgggaga gaatattcag tatcaaggac cggctggaag 1378561 cggacagcat accaagatgt gcaatcagat tgcaattgca gccggtatga tcggtgttgc 1378621 tgaagcgatg gcttatgccc aaaaatcagg cctagagccg gaaaatgttc tgaaaagcat 1378681 cacaacgggc gcagccggaa gctggtcatt gtcaaatctt gctccccgta tgctgcaagg 1378741 caactttgaa ccgggatttt atgtgaagca ttttattaag gatatgggaa ttgcactaga 1378801 ggaagcagaa ttaatggggg aagaaatgcc aggcttgtcg ctcgcaaaat ctttatatga 1378861 caagctagct gctcaaggtg aagaaaacag cggaacacag agtatatata agctttgggt 1378921 gaaataaaaa aagattgcct gtacgaaaca ggcaatcttt ttttattatt ttccgatgaa 1378981 ttgttgtgtc cagatgcttc cagactcaac gtaaccaaca ccgatgtgag taaagttagg 1379041 gtttagaatg ttttttctgt gtccttcact gttcatccaa gcttttacta cttcttctgg 1379101 tgtcttttgg cccttcgcaa tgttttcacc tgctgttttg tagctgattc cgaaagattt 1379161 catcatatca aacggtgagc cgtatgttgg gctttggtga tcaaagtagt ttttgtcttt 1379221 catatcctga gattttgcgc gtgcagattt gcttaacgtt tcatcaattt gaagcggttt 1379281 taagccttgt ttttgtcttt ctgcatttgt aagttcaaca acttttttct catatgcact 1379341 tacagatgaa ggtgcagacg ttgttgtgtt tgttttttca gcagttgcgg gtgctttaga 1379401 agcagtgttt tgatcagcag ctgctttttc agtagtcttt tgtgcaggtt ttgccgtttc 1379461 tgtcttttga acatcctgaa ctttcacgtt agattgcttc gcatgttttt gaagaagctg 1379521 cttcatctct ttttcgtttg cagcgtttaa cgttttgata tttgtgttaa tatgcagttt 1379581 tttcactgca tcgttaagtg acatgttttg tactgtgttc cccgttttta ctgtaaccac 1379641 aggctggcag gagagttctt tcgctgatgc ttgctgtacg cccccgaatg tgaataatcc 1379701 aaccgcagcg gcagcagata aaataaatgc tttcttcatt agttcgtaac ctcctagagt 1379761 tgtttgtttc tacagaaaaa tcataacata gcttttttgt cataaagatt ccagcacttt 1379821 cctttgacaa atagagattg tcattttcgt aaagtaaatc cgttgaatca ctaagaataa 1379881 gggaatcagc ggtatatatg attttatcgt accgttacat agcttccttt tttttgaacc 1379941 gttagttata ttttaatgtg tttttatatt gacagctttt tttactcctt ttcgctgtaa 1380001 caactattac aaaggtgtta caattaatct cagtatatgt aaatatattg aatgatttga 1380061 gaggggtaac cagaagtgac tgaaatagga cgtgaaccaa agaaaaagag caaaggaaac 1380121 agagcaatca gaatgaacct ttttttccta gctgtctttg ttctattcac tgcattaatt 1380181 tttaagctcg gggttgttca aattgttgaa ggcgaacagc atgaagaaga cgctgagaaa 1380241 tcaaatgcaa aaacagctta ctatcctgcg cctcgcggga agatgtacga cagaaaccag 1380301 aaagttgctg tcgacaacca gagcgttcca gaaattgtgt atgtatcaac atctagcaca 1380361 aaaacagaag ataaaatcaa aacagcgaag cggcttgctt ctttcattca tattgatacc 1380421 gaatttttga aggaaaggga tcttcgtgat tactggatcg cagctcatcc gaaaaaagcc 1380481 gccgctctgc ttaaggaatc agaaagcaat ctgaaaggag accaggctta caagcttcaa 1380541 atagagcgtg ttccggatca agaattaaag gctattcagc aagatgacga agaaatggaa 1380601 actgctgcga tatatacaag gttttcaagc ggaaatgctt acgaacctca aatcgtaaag 1380661 gcaatgaatc caaataagag caatagcaat ggaaaaaacg gagcgctgct tgatgagaag 1380721 aaaaactcct cgcaaagacc aaaaaatgac ttaacatatg atgaaatttc cattgtttct 1380781 gagcatttag aagaacttcc gggaatcgat atcgtaaacg attggacacg aaaatatcct 1380841 tatgacaaaa ccctttattc tgttttcggg ggcgtcacga cacctgatca gggcctgctg 1380901 agcgaccgga aagatttcta cttaacaaga ggctatgcga ataatgacag ggtgggaaaa 1380961 agttatttag agtatcaata tgaagaatat ttaaattcgc ataaagaaaa agtggaatac 1381021 gtagaagata ataaaggaaa tgtcgtcagc caaaaaacca ttgataaggg cagcagggga 1381081 tacgatcttc agctttcttt tgacatggag cttcaggcaa aggtagaaaa gatcattgaa 1381141 gaagaagtaa gaaacagccg tgcacgcgga aattacatgc ttgacagagc ctttgccgta 1381201 atgatggacc cgaataacgg cgatatttta tcaatggcag ggaaaaagat agatttaaaa 1381261 accaacaaaa ttgaagatta tgcgataggg gcatttacca cccaatatga aatgggatca 1381321 gcagtaaagg gggccaccgt gctagccggc tatcaggacg ggatcccgca ttataaatat 1381381 tatatcgatg ctccaatgct tttaggaacg aatcttataa aaaaatctta tactaatatg 1381441 ggaaccatca atgaattaac cgcattgcaa aaaagttcaa acgtatatat gttcaatgtt 1381501 gccatgcata ttgcaggcgt aacatacaag ccgcatggat ctctcccggc tgatcagaac 1381561 gatctactga aaatgagaaa ctattacagc cagtttggtc tgggagtaaa gacaggtatt 1381621 gatctcccgc aggaatcagc cggaatgcaa accacaccta aaactgtagg aggattaatt 1381681 ttagacttag caattggcca atacgataca tacacaccgc ttcaaatggc tcaatacatc 1381741 tcagtaatcg ccaatggtgg ctatcgtgtt cagcctagaa tcgtcacaag tattcataag 1381801 ccaggaaaaa aagaccagct gggtaaggcg attgaacata ggaaacctaa agtactcaat 1381861 aagattaata attcagagag cgatttgaaa caagtacaaa caggcatgaa attagtcact 1381921 tcttcaggga cagcaaaaaa tacgtttaca gaagatgtat cagggaaaac gggaacagcg 1381981 gaaacatttt actacggcac gaatcgcaac tggtggggga aaaaaacata caatctgact 1382041 tttgtcggct attacccgtc gaaaaaacca aaagtggcct ttagtgttgt tgttccatca 1382101 gtagatgatg atgataagat caataaaatt attgccaaaa gagctatcca cgcctacgca 1382161 gagctcgaaa aaaaacacag taaaaaataa aaaacagggt gcacaactaa aagattgtgt 1382221 gccctttctt ttattcaaaa attgacgttc accataagaa tagaaggaga atactcattt 1382281 tctagcgaat catactaggt aaaagtcaat ctgtatatgt cgaaacacga tgatcatgca 1382341 aaggagggat tctgtggaac aggatacgca gcatgttaaa ccacttcaaa caaaaaccga 1382401 tattcatgca gtcttggcct ctaatggacg catcatttat atatctgcca actccaaact 1382461 gcatttgggc tatctccaag gagagatgat cggatcattc ctcaaaacgt ttctgcatga 1382521 ggaagaccaa tttttggttg aaagctattt ttataatgaa catcatctga tgccgtgcac 1382581 ctttcgtttt attaaaaaag atcatacgat tgtgtgggtg gaggctgcgg tagaaattgt 1382641 tacgacaaga gctgagcgga cagaacggga aatcattttg aaaatgaagg ttcttgaaga 1382701 agaaacaggc catcaatccc taaactgcga aaaacatgaa atcgaacctg caagcccgga 1382761 atcgactaca tatataacgg atgattatga acggttggtt gaaaatctcc cgagtccgct 1382821 atgcatcagt gtcaaaggca agatcgtcta tgtaaacagc gcgatgcttt caatgctggg 1382881 agccaaaagc aaggatgcta ttattggtaa atcgtcctat gaatttattg aagaagaata 1382941 tcatgatatc gtgaaaaaca ggattatacg aatgcaaaaa ggaatggaag tcggaatgat 1383001 tgaacagacg tggaaaaggc ttgatggcac acctgttcat ttagaagtga aagcatcccc 1383061 gaccgtctac aaaaaccagc aggctgagct gctgctgctg atcgatatct cttcaaggaa 1383121 aaaattccaa accatcctgc aaaaaagccg tgaacgatat cagctgctga ttcaaaattc 1383181 cattgatacc attgcggtga ttcacaatgg aaaatgggta tttatgaatg aatcgggaat 1383241 ttccctgttt gaagcggcta catatgagga tttaattggc aaaaacatat acgatcagct 1383301 gcatccttgc gatcacgagg atgtaaaaga gagaatccaa aacattgccg agcaaaaaac 1383361 agaatctgaa attgtcaagc aatcctggtt cacctttcag aacagggtca tctatacgga 1383421 gatggtctgc attccgacga ccttttttgg tgaagcggcc gtccaggtca ttcttcggga 1383481 catctcagag agaaaacaaa cagaagaatt gatgctgaaa tcggaaaaat tatcaatcgc 1383541 agggcagctc gcggcgggaa tcgcccatga gatccgcaac cctcttacag cgatcaaagg 1383601 atttttacag ctgatgaaac cgacaatgga aggcaacgaa cattactttg atattgtgtt 1383661 ttctgaactc agccgtatcg aattaatact cagtgaactg ctcatgctgg cgaaacctca 1383721 gcaaaatgct gtcaaagaat atttgaactt gaaaaaatta attggtgagg tttcagccct 1383781 gttagaaacg caggcgaatt taaatggcat ttttatcaga acaagttatg aaaaagacag 1383841 catttatata aacggggatc aaaaccaatt aaagcaggta ttcattaatt taatcaaaaa 1383901 tgcagttgaa tcaatgcctg atgggggaac agtagacatt atcataaccg aagatgagca 1383961 ttctgttcat gttactgtca aagacgaagg ggaaggtata cctgaaaagg tactaaaccg 1384021 gattggagag ccatttttaa caacaaaaga aaaaggtacg gggcttggat taatggtgac 1384081 atttaatatc attgaaaacc atcagggagt tatacatgtg gacagccatc ctgaaaaagg 1384141 cacagcgttt aaaatttcat ttccaaaaaa ataaaaacaa cggcttaaac gccgttgttt 1384201 atcgtctgca ttgcttcacg tttttttaat acaaataatt ctaaacggtc taggccttct 1384261 ctcagcgtgt ccattgagca tgcaaaagac agccttacat atccttcacc atatgttgag 1384321 aacgagctgc ccggcacgag tgccacgcca gcgtcttcca aaagagccat actaaaatca 1384381 aatgaagtca ttccaaatga tttaatagaa gggaagatat aaaacgcacc ggacggttta 1384441 actacgtcaa gtcccatgga aacaagacgg tcataaacat agtccagacg ttttttgtat 1384501 tgttctctca taatcaatgc atcgtcaaag ccgtttgtga cagcttcaag cgcggctttt 1384561 tgagaaatgg atgaggcgca cgacacattg tattgatgaa cctttaaaat gtgctttgca 1384621 atgtctttcg gtgcaaataa aaatccaatt ctccaaccgg tcatgctgtg tgattttgac 1384681 aacccgttaa tgacaatcgt ttgatcccgc aaataggttg cgatggagta atgcggtctg 1384741 tcatatgtta attcactgta tatttcatca gacaatacga agacatttct gccttttaag 1384801 agagctgcga tgcttttcag ttcttcttca gataaagtca cgccggtagg gtttgacgga 1384861 taaggaagca cgacacactt ggtgttgggt gtcagagcat cttcaatcag ccgggcggta 1384921 agcttaaagc cgtgtgacgt agtatcaaca atgacaggct tggccccgca caaattgata 1384981 ataggttcat agcccggata aataggccct ggcataatga cttcatcacc gggagataaa 1385041 atcgtccgga atgcagcatc aatggcttgg cttgcgcctg ttgtgatgat aatttcagat 1385101 tcagcatcat agttgaaatc cgcttttttc ttcatataaa gctgcacagc ttgtctcagc 1385161 tccaggtagc cggcattcgg agtatatgac gtcacgtttt catcaatggc tttttttgcg 1385221 gcagctttca catgatgcgg tgtgaaaaaa tcaggctggc cgattgtaag tgaaatgacg 1385281 tcttcgtgtt gggctacaag attcgagaat ttgcgtattc ctgaaatttc gatctctctt 1385341 gctttcggat tcagcaaatg ttccataatt catcacctta acaaatataa tgagtttatc 1385401 ctattttacc actagctgat catttgtcac ctttttaact gatatatttc gattgtatgc 1385461 gccttttttc taaacatacc tttcttttca gaaaaaaaga agacaaccag cgatttgatt 1385521 gtctttattg tatcatgttc tattattgtt tatatgtgcc aatttcatta atagccataa 1385581 tcaaaatgaa ggtcttcgtg ccaaatcaga tacggaggat gctcttcttg aaggtcagct 1385641 gattctttct tcatattcag gtaagtttct tcactgatat cctctaaaac agtcatttcg 1385701 ttttctttaa atattactaa ggtacccatt atttacaccc ttctttggaa aaatccttga 1385761 ctattttatc actgttagtt ggaaagtcaa tggttattag gaaaaaagtt tcttttttga 1385821 ggaacgcggc ttgttgcctt cggaattcga ttttgaagag ctgccattca ctttttacaa 1385881 attacgccga tatatacagt acaatactga atgcgaatag cgagggattg aattgtcgtt 1385941 acaacaatac gaaattttat tggattctgg tacaaatgaa ttagaaattg tgaagtttgg 1386001 cgtgggtgaa aatgctttcg gaattaacgt catgaaggta agagaaatta ttcagcctgt 1386061 cgaggtgaca tcagtgcctc actcccatca gcatgtagaa ggaatgatta aactcagagg 1386121 agaaatcctc cctgtgatca gtctcttctc attttttgga gtagagcctg aaggatcaaa 1386181 agatgagaaa tatatcgtga ctgaatttaa taaacggaaa attgtttttc atgtcggctc 1386241 tgtttctcaa attcacagag tatcctggga agcgattgaa aagccgacat cgttaaatca 1386301 aggaatggag cggcacctta ccggtattat taagctcgaa gacctgatga tctttttgcc 1386361 tgactatgaa aaaattattt atgacattga atcagattca ggtgttgaca cgtataatat 1386421 gcataccgag ggcttcgatg aaagaagaac tgataaaaag cttatcattg tagaggactc 1386481 accgcttttg atgcgcctct tgcaggatga attaaaagaa gcagggtaca acaatatcgc 1386541 ttcgtttgaa aatggaaaag aggcatatga atacattatg aaccttgctg aaaacgaaac 1386601 tgatttatca aaacagattg atatgatcat cactgatatt gaaatgccaa aaatggacgg 1386661 acacaggctc acaaagctgc tgaaggaaaa tccgaaaagc tcagatgtgc cggttatgat 1386721 tttctcatcg ttaattacgg atgatctgcg tcaccgcggc gaagttgtag gcgcagatga 1386781 gcaaatcagc aagcctgaga tcagtgattt gattaaaaaa gtggatacgt atgttattga 1386841 ataaataaaa acagccgttg ccagaaagag gcacggctgt ttttatttta aaagtaactc 1386901 tcgccaagtt ttttaaagac cggtttatgg taagctggct gctggcgatt tggcactagc 1386961 ggcttttctt tcatgccgac atattcttgc aataggtgtt tcgcttttgt taaagacatt 1387021 tgagctttag gatttcgata cgattgatta agtgtaccta aatgcggaag atgttcgaag 1387081 tcttctttag ttggaggcat gtgaaaatag tagtctccga ttgagataag cacgtccgat 1387141 tgctgttggc tgaaccttgg attttttgaa aaatgaagcc ctattttctt tcctttacct 1387201 tctttgacaa gcttttgcaa agcccgtttt ttcagcagat ataggtattt agggttgggg 1387261 gcggtttttg catggcggtt cacagtgtaa actgcttttg aaagattttc tacggttggc 1387321 tgcagatctt tcgtatatgc atggtcgtcc attatttctc tcctttgctc ttatcaattt 1387381 ctatatgttt agattatact tttttaaagt tgaaatgcaa atattgaatg taaaaatgcg 1387441 cttttttcta agaaaaaaag cgcattttta acctgcatta tacagatctt gccttctttt 1387501 tcggctgttc ttgaaatgct tcctgaacat tcacttccac agcctgagca ctgtattttg 1387561 gcagtgcaat aaaataaaaa ataaaaacga gcaggataat aacacccatg ccgtaataaa 1387621 gataatcaat gtttgaaaca aacttaggga ataacagcgc gactaagccg agtgtcaaag 1387681 attgtgcaaa catcataaaa gggtcctgca tgccgcttac acgtcccatc agttttggat 1387741 gaacaatttt tggcatccac cctccgattg caatgttgat cggtccgata cacattccca 1387801 gtgcaaaagc tgccgcgtaa tacacccata aaatattggt gtagccgagg acgaagatca 1387861 gcaaacctgc aatgaaaatc ggtatcgaca ttaaaaagtg cggcttcact tttttagaga 1387921 tgagcgtgcc gattacgctt cctgccagaa gcccaaaccc gagtgcgatc gtaaatacag 1387981 acgtatgcca ctcataacgg tcaggcgcca atccatattt cattgtaaac atcggcaata 1388041 cggcgaatcc tccattgaca aatccaaaaa tgaagaagcc aaaaataaga gatgccagca 1388101 atttgttttt taaaatatag aggatgcctt ctctaaagtc atttattgaa tccttaacag 1388161 aagtctttct ccagctgaat gcaccgtttg gctgtcgggc ttcttttgga atccggcagc 1388221 tgcggatcag cagcccggaa atgataaagc tgacaaaatc aagaataatg gcgccttcaa 1388281 taccgattgt gttgtacata aacgcgccta tgccgactcc aaacaccata aaaatgctaa 1388341 aaagcatctg attaagccct gccgctttcg cataatgctc cttcggcaga atggcttgta 1388401 ccaaactgtt ttctgccgga aagaaaaact ttgttacagc gcttctgata aataagatac 1388461 aaaaaacaag aggaatattg ccggtaaata aagtgaaaaa aagcacgaca gtcaggcctg 1388521 ctctgatcca atcacaattt tctgccacct tttttctatc aaaccggtcc gcgacgactc 1388581 ccacgatcag aaatacaaat atggtcggaa gagaatacat cagctccgcc aaggtcgtat 1388641 atgaaggctg gctgctgaat cggtccagca aaaaaaaagc aaaggccatg ttgcctactg 1388701 tcgtgcccat ttgagaagcg agtgctgcga aaaatagacg aacaaaatta cgatttttaa 1388761 atatatccat aaaaacgctc cttaccctaa aggtcccact ttatcatatt ataaaccgcc 1388821 tgtttttgaa acaaataaga aaacattacc ggttaatcgt gactctcgtt ccgtttggca 1388881 caattgaagc aagttcgatc acgtctttgt tatgcatgcg aatgcagcct ttagaaacag 1388941 ccttaccaat cgaagcggga ttattcgtcc catgtattcc gtagtgctgc tttgaaaggc 1389001 tcagccaata agcgccaaat gggccgccgg gattgcgctg gcggttaata atgtaaaact 1389061 cgccagtagg cgtttgcgtt agtattttac caacggcgat gggataggtt ttcattaccc 1389121 gattatttag ggacagcgta agggtcttcg ctccgattga gactgcgata tgatacggaa 1389181 ttgtataagg gtccggcagt ccggggatga ctatggactg tcccgcggtg agccctgcct 1389241 gcagtgacgg attagcctgg agtaatgcag ccgtgctgat tctgaaatca gccgcgatgc 1389301 tgttcagtgt atcaccttgc ttcacctggt acgtaagcag tttcctcatc ctcctttttt 1389361 acttataagt attgatgagg agcccatcct gctacattaa tttgtgcttt ttaaggtgaa 1389421 gacagtgatt tcaggcttgg caagaaaccg caaaggcagc ctggtcatcc cgaggcctcg 1389481 gtttacgtaa atatgagtgc tgcccgtttg atacattccc tctgtgtaga cttttccata 1389541 tggaggcgta ataatcggtc cgtaaaaagg cagctgaatc tggccgccgt gtgtatggcc 1389601 ggaaagctga aggttcacgg gataatctgt tgttttcaag gctgcatcag gttcatggac 1389661 gagaagaatg gaaaaaagtc tgtcgctcag ccttgaaagg gtgccttcat aatctgggtt 1389721 tcccagcatt aagtcatcaa gcgaagcaat ctcgattttg ctgccatctg cgagtgacaa 1389781 tgtttgatag ccattgcgat ataccgtgaa acctccggcc gtcatcaggc ttttgtaaac 1389841 ggcagttcca tagcctccgt gatcatgatt gccgtaaata caaagcttgc cgaagggagc 1389901 attaagcttt ctcaataatg gaatgactgc ctggtggtgc tggtacgtat caggattatc 1389961 aataatatca cctgtaaaaa caatgagatc aggtttagat tcattaattg taagaatgac 1390021 agtttttaaa tcttcgagag taaagtaatc actcaagtgt gcatcgctga actgcacgat 1390081 tttaaaaccg tcaaatccgt gcgggatgag agagcttttt attgtgtgtt cggttgtctc 1390141 gatcatatgc ggctcgagat acctggcata gccatatccc ccgccggccg ttaaagcccc 1390201 ggcagcaaga gcgccgaaca ttccttttag aaattgtctt ctggacatct ttttcatttc 1390261 aaaccaacct ttaatagagt ttttctatta tatcatctgt atctgataaa aatctcatat 1390321 gagcatgtgc tgacagaggc agggatataa tgatagaata ttattgaatg aataatcatt 1390381 cacaattgga gggataaaca tggaaaaaaa ggcggtaatt attaccggcg ggtcaagcgg 1390441 catgggaaaa gcgatggcaa aaaaacaggc tgaattaggg tggcacgtta tggtgacagg 1390501 gaggaaccat gaggcacttg aggaaacaaa aaaagaaatt cagacctttg agggacaggt 1390561 cgcttgtttt caaatggatg tccgttccga ttccgccgct tcagacatga ttaaagaagc 1390621 ggtaaaagcc tttggccggc ttgacgcgct gattaacaac gcggccggaa actttatttg 1390681 tccggcagaa aagctgacgc ccaatggatg gaaagccgtt attgagattg ttttaaacgg 1390741 cacatttttt tgcagccaag cagcggcaag gcattggatt gaccagaagc agcagggtgt 1390801 cattttaaat atggcagcca cgtacgcttg gggagcggga gcgggggtcg ttcattccgc 1390861 tgcagccaaa gcgggggtat tgtcattgac aagaacgctg gccgttgaat gggggagcaa 1390921 atacggcatt cgtacaaacg cgatagcccc cggaccgatt gaacgaacag gcggtgcgga 1390981 gaagctattt gaatcggaaa aagcgatggc ccgcacgatg aacagtgtgc cgctcggccg 1391041 attgggcaca ccggaggaaa tcgccgcttt ggcagcgttt ttgctttctg atgaagcatc 1391101 ctatataaac ggggattgta tcacaatgga cggggggcaa tggctgaatc cttatccgtt 1391161 ttaatctgaa tatttataag tgaatattta agttattaag aacttttatg ttcgaatgta 1391221 atacctccac aattaacctt cttcctatcc aatttgataa cacatagagc tttatttgtt 1391281 tatgaggtgt tgtgtcatac gtaagccacc taatatatga aaggtatatt ttaaaagggg 1391341 agacgaaata tgaagaactt agatttcaaa taaaacattc atataattac ttcgttaact 1391401 aaaaagagaa attataagaa tgaaaggttt caaggttaca tcagattggg aggaaggtaa 1391461 tataatggac gagatggtat tattaactca ggaatggctc aatgaaacgt acaaaggaaa 1391521 aagtggctac aattccattg aggaaaatgg gaaaactggc tggaaaacaa tgtatgcatt 1391581 aactagagca ttacaactag aattgggaat tacacagact tccgacagtt ttggtcctac 1391641 aactttaaga aagcttaaag aattaggccc gatttctacg tcaactaatt caaaaaaaaa 1391701 tattgtgaaa attattcaag gtgctcttta ttgtaaaggt tatggtccag gtggattaac 1391761 gggtacattt ggtcagggaa cgaaagaggc gatagcagaa atgcaattgc atatggggct 1391821 ttctaaaaca gacggtgtag taacgcctaa ggtgtttaaa gctttattaa acatggactc 1391881 ttatatcctt ttaaatgggg cgtcagagaa agttcgttca atacagcaat ggctaaataa 1391941 taaatattac aatagagaga atttctactt tatgccctgt gatggcctgt attcaaggga 1392001 tactcaaaag tctcttgttt atgcaataca gtacgaggaa gggttaagtg atagtatagc 1392061 taatgggaat tttggaccaa ctactcaaag attgattcct gtattaagaa ttggagaaac 1392121 agatgaaaaa aacagtttta ttcatttatt tcaagctgct ctaatcttta atggctacaa 1392181 tgttcctttt gatggagtat actctgaatc tgtaagatca aaagtaaagg cttttcagtc 1392241 ttttgcaaaa ttacaacaga gtggtactgc cgactttcaa acatgggctt cacttctagt 1392301 aagtactgga gaccccaatc gaaaaggagt tgcttgtgac tcaattactc aaattacatc 1392361 ggacagggcg gagtccctta agagggcagg ttataagatt gtagggcggt atctaacaaa 1392421 tgcgccgggg agtacactaa ataaaaaaat acaaccaggt gaattagaaa ctatcttaaa 1392481 atcaggttta aatgtttttc cgatttatca aacctatggg ggagcaacaa attattttaa 1392541 taaagaacaa ggaaagaaag atgcgtttgc tgcttataaa gcagcaaaag aatacgggtt 1392601 taaaaataac actgtaatat actttgcagt agattatgat gcatatggta acgatttaaa 1392661 caacaatatt attccacact tcgaaggtat aaatgaaata atgaacggtt ttttaggttc 1392721 aacttacaaa attggtattt atgcccctag gaatgtatgt actatagttt ctaaaaaagg 1392781 tttagcattt gcaagttttg taagtggtat gtctactggc tttagcggaa acttaggata 1392841 tcctttgcct tacaattggg cgtttgacca aatttcaaca attactgttg gaaatggttc 1392901 tggaatgatt gaaattgata atgatatttg ttcaggtttg gataatggag ttaataccat 1392961 aaatatagtg ccttcagaga ataagaagtt ttttgatcaa attgatgttt tatatgaaac 1393021 tgctgaaaaa tatgctcaaa tgcaaagcga cttaaataat ggggtaaaaa aaacacaatt 1393081 agctaatgag ttggttgccc agtatttaag aaaggatgac tacaaagggt ggaagtgggt 1393141 ccctaccgca ggccagattg atcctattta tcgtgaatgg gcagtaaagc gctaggggaa 1393201 gacctagtaa atggaattgt tgatcctata tcaaaaactg tcataggaac gcagcatctt 1393261 atggcaactt ataatgccat tatttatagt ggtggttact ctcaaacact acgagatttt 1393321 gctggttgga ctggagatct attaacaaca atacaggaca tgaaattaca cgctcaagaa 1393381 tttaattcgc cttatgatgc ggctatgaaa ataataggta atatgtatca atttagccta 1393441 gatgatttat ttagtgatgt agatgcaatt aatctagcga ataaaacatc agttggtgct 1393501 aatgcacaac ctctaaatat cgcaattaga gattattata gtaataatga ctgtatgaat 1393561 aggttcactc aatttgtaaa taatagattt gatggttcgt tagacaaaat tttctctgaa 1393621 gcagagtatt atttaaatac aaaccttgac ccagttgttg ttccaattag gttagccttt 1393681 aaacgtgctt ttgatgttga ggattatagt gaagagattg gaaaaataac agcacaagca 1393741 tttagagatg ttatcgagaa aaaaatgata tctgaataaa ctgcaaaaca agcgaacgtt 1393801 aaaactggtc gttcgcttgt tttattttct atttaaattt atgatataat ttttaaagat 1393861 taaggagtga ttcattgaag aaattgttaa aaaagttagt tgtattattt ttaagcagtt 1393921 tagttatcat ctttaatgtt tggtacttta ttatttgtgc tttttcccca gagtattatc 1393981 aaaatacaaa tcttacttct aatgaaataa taagatttga aaaactatac cacatagatt 1394041 ttcctgatga aacaaaattt attaaagcta gagagtattt ggctgggccc ggaggagata 1394101 cgtcagctgt attatatgtg tctctgccaa ccaagcgggt agaaaaagtt ttatctgatt 1394161 acacgtatat gaaaataaac tatactgaca atgtcggttc aatgtatgga gttgacgttt 1394221 caaagagtgt cgccggttta acaactctta catttggcac ttacgataaa aaaggaactt 1394281 tctataatat gaaacatgat gatgattgga tgtataaagg cactgactgg aatctttact 1394341 tttggacagc tgctagttat aatgctgtta tttttgtatt tgttttggtt attgtgaaac 1394401 aaatgaataa aattcttaat taaccagtat gtagattgat aatctcaaaa aaattttcct 1394461 cttcttttaa catactccat acgacctact tttccatact atgatttttt tgaaatttgt 1394521 ggtgtagtta taattgtgcg tataatcaga caaagataga gaagcaggtg ataacatgtt 1394581 ggatccactt gatattttaa cgaacattga tgatgtcctt ccatattacc aggcgatttt 1394641 tagtgccgag gagcagaagg ttgtcggata tgaggtgctt ggacgaattt tggcagattc 1394701 agaaatccaa agtctcgggc ccttcttttt agatgcgggg atacccgaag aatataaatt 1394761 agaggttgat aacagaatta tccgccaggc tcttgaccgc tttttagagg cggattctga 1394821 tctgctgatt tttatgaatc aggatgccaa tctgctgatg ctggatcatg gtgaaagctt 1394881 tctggagctt ctgaaagaat atgaagcgaa gggaatcgaa ctccaccgtt ttgtgcttga 1394941 aattacagag cacaattttg aaggggatat tgagcagctc taccatatgc ttgcatacta 1395001 tcgtacatac ggaattaaaa tcgcagttga caacatcgga aaagaaagca gcaacttgga 1395061 cagaatcgcg ctgctctcac cagatctgtt aaaaatcgat ttgcaggcgc tgaaagtgtc 1395121 acagccgtca ccgtcatatg agcatgtgct gtacagcata tctttattag caagaaaaat 1395181 cggtgcggcg ctgctgtatg aagacattga ggcgaacttc cagcttcagt acgcctggag 1395241 aaacggaggc cgctattttc agggctatta cttagtgtct ccatctgaaa cgtttctaga 1395301 gagagatgta ttgaaacaaa gacttaaaac tgaatttcac caatttatca cacatgagaa 1395361 aaagaaactg gagaccgtct atgagcactc tgaacagttt tacaaacgag tgcatcaggc 1395421 tgtgacctct ttgagaaaaa acaatctgtc ttctgatgat gactttatta aaaagctggc 1395481 ggaagagctg acagattgca gcttcaggat ttacatgtgt gatgaagaag gcgatcagct 1395541 gacgggaaat gtgtttaagc aagatggaga atggatttat cagccggaat atgcggaaaa 1395601 gaactggagc tggcgccctt attttctgga gaacattatg agaatgagaa atctcagaaa 1395661 aggttttttc agtgatctgt acagtgattt ggaaacaggt gaaatgatca gaacgttttc 1395721 atatccgatg gatgatcaga tgtatttatt tatagacttg ccttattctt atttatatga 1395781 gcaggacgga ctgatttaac ggctgaaagg ccgttttttt tatgaaatga aaaaaatatc 1395841 aaaaaacgat tgacattgat actgagaatc attatcattt aattatagag agaagctact 1395901 ctctgttccc caacccctct atcagatcaa gatccgaaaa aacttggcgc tacccccgcc 1395961 aagtttttta tttgtcaaag cataggacaa tccaatgaaa caataaacct aactagtggt 1396021 aaacgtttaa cacggggaga aacattgagt gccgaacacc cctgacactg ctgcacgggt 1396081 gaggaggaaa attcgttctg aaatgattat ttcagttccg ttgtttacct ctatccagca 1396141 tgactcccat tgattatggc cacgcgggac ttcaccataa aattcaaaag aaggttttga 1396201 caaagttgca aaaaggcatt cttaatgctg ccaaagattc gaaaaaaatt ataattatgt 1396261 gcatgacatt caaaaaaagc ctcaaactaa agaaaaatag tttttttcac tttttttctt 1396321 tgcttaaatt cagcagtgaa aatgccatcc tgtccgactt tatggtatga tgctcaatag 1396381 aacttgtatt ataataaata cttgttgatt tgaagttgct ttttgaaagg agtctttttt 1396441 tagaatgtca caattaatgg gtatcatcac acggctgcaa agtctgcaag aaacagcgga 1396501 agcggctaac gagccaatgc agcgttattt cgaagtgaat ggtgagaaaa tatgcagtgt 1396561 taaatatttc gaaaaaaatc aaacgtttga actgacggtt ttccaaaagg gtgaaaaacc 1396621 taacacatat ccgtttgata atatcgacat ggtttccatc gaaatctttg aacttcttca 1396681 gtaagattcc tgaaataggg ggaacaagct tccgcctttg caaaagtaat cgaaataaac 1396741 ggtaaggaac atacttgttt catggttgta aatccttgaa aaggagtgtc gtgatggctg 1396801 attcttttct gttttataat ctttcagaag cacagatgac ctttcaagat gtgatggaac 1396861 ggcttaaagc ctttgttcaa aaggaccccc gttcttctta tgtgttatcg atcggaaccg 1396921 attcacaggt ttaccgcgat tacacaaagt ttattaccgc attgcatttg catcgtacag 1396981 gcaagggagc ttggggctgc ttgaaaaatc atacagtcga cagacccata catagccttc 1397041 gggagaagat ttcgttagaa acggcgtaca gccaagaaac ggccgctcat attcttgatg 1397101 gacacttaat ggatattacc gatctgctcc tgccctttac cggtgagggg gcggatctta 1397161 cctttgaagt tcacttggat attgggaaaa aagggcttac aaaagatctg atccaagaaa 1397221 tgactggacg tattacctcc atggggattg aggccaaaat aaagccggat tcatacactg 1397281 ccttcagcta tgcaaatcgt ttcacaaaat aatttggctg aaaaagccaa ggtaaatgtc 1397341 gaattatgcg gttgacgttt gttatctgat tacttattct agcggtagag ctgaaagtaa 1397401 gttgtcttgc tttcagaggt attcagtata aaacaggggg cctgattgcg aatgagtctt 1397461 atcggtgaac gatttacaga agaagaacaa aaacttctgc tgaatatcct gatcaaccat 1397521 gagtatgcca tcgagctatt aagcagtgag atcaacgata tagagacagg gaccaaaaac 1397581 gttgacggaa ccacctacaa aaaacttgta acgctatacg accgatttcg atttgaaaat 1397641 taatgggaca ccctataatt gatactccac aaagagtatc ttttttattg aaaggaaact 1397701 tttcgacaaa tactgataaa gtttatatta ttgcaatata gggaatgtat tgatgatgaa 1397761 aatgaaaagg ggtcgaaaac atgataagct tacaatcaga tcaacttctt gaggcaacag 1397821 tcggacaatt tatgattgag gcggacaaag tagcgcacgt gcaagtcgga aataaccttg 1397881 agcatgcatt attagtattg acaaaaaccg gatacacagc catcccggtt ctggatcctt 1397941 cctaccgttt acatggctta atcgggacaa atatgatcat gaacagtatt tttggacttg 1398001 agcgaattga gtttgaaaag cttgaccaaa tcactgttga ggaagtcatg ctgaccgaca 1398061 ttccgcgcct tcatatcaat gatccgatta tgaagggatt cggcatggtc attaataacg 1398121 gatttgtctg tgttgaaaat gacgagcagg tatttgaagg gatttttacg agaagagtcg 1398181 ttttaaagga attgaataag catatacgct cattgaataa gtaggctgta cggtcctatt 1398241 tttattatat aggcagagtg aaaaaagaaa gcgcatacat aatttaaacg agaatagggc 1398301 ttgaataaga aactaagatt ttattagaat gggagataag aaaaacttat tgataacaaa 1398361 aaggaggacg acatgcagct tcaagagctt catatgctcg tagttttagc tgaggaatta 1398421 aatatgagaa aggcggcaga acggcttttt gtatctcagc cggctttatc tcagcgctta 1398481 caaaccattg aaaaggcgtg gggaacaaaa atctttttaa gatctcaaaa aggattaacg 1398541 gtaacgcccg ccggtgagaa aatcattcag tttgcgaatg atgtgacatt agagcaggaa 1398601 agaataagag aaaatattga cgagcttgaa ggtgaaattc acggcacatt gaagcttgcc 1398661 gtcgcctcca taatcggtca gcattggctc cctaaagtcc tgaagacgta tgtggaaaag 1398721 tatccgaatg caaagatctc gctcataacc gggtggagca gcgaaatgct gaaaagcttg 1398781 tatgaggatc aggttcatat cggcattata agaggcaacc ctgagtggaa ggggcgcaaa 1398841 gattacttaa tgacagatca tctgtattta gtggatactg aaatttcctg catcgaagat 1398901 attgcccata cagaacgtcc gtttatccag tttaaaagtg acagcactta ttttcaggaa 1398961 attcagcact ggtggcatca aaaatttaaa acgtcgccga aacagacgat attggttgat 1399021 cagattgaaa cgtgcaaaca gatggcgctg cacggaatcg gttatgccat tttgccgtct 1399081 gttacccttc aaaatgaaga taaagtgaat aaaatgcctc ttttagacat gaaagggcat 1399141 ccgatcggtc gggatacatg gttattaggt tatgagcctg cctttgaact gaaacaagtt 1399201 caagcttttg tacaagtgat aaaggatatg ctggatcagg aaaatccatt ttaaagacag 1399261 cgaggtgctg tctttttttt atttatctgt tgacaatgaa aatcattatc atttaaagtg 1399321 atacatatga tattgaaaat cattatcaac taatggggtg ataacatggc taaagccttg 1399381 attacatatg ccagcatgtc aggaaataca gaagacattg ccttcataat aaaagatacg 1399441 cttcaggaat atgagttgga tatcgattgt gtcgagataa atgatatgga tgcgtcttgt 1399501 ttaacctcct atgattatgt actgattggc acctatacat ggggggacgg cgatttgccc 1399561 tacgaagcgg aggatttttt cgaagaggtc aaacagattc agcttaatgg tttaaaaaca 1399621 gcctgcttcg ggtctggcga ttattcttat ccaaagtttt gcgaagcggt gaatttgttc 1399681 aatgtcatgc tgcaagaggc gggagctgct gtttaccagg aaacactaaa aattgaatta 1399741 gcgcctgaaa cagatgaaga tgtggaaagc tgccgagcgt ttgcgagagg ttttcttgca 1399801 tgggcagatt atatgaacaa ggaaaaaatc catgtttcat aaaggggcaa ccgctgttac 1399861 ggcatcggcg ttttctggat attttgtggc ggtacaaaga gaaggcattt ttcattactc 1399921 tttggagcag ggctggagaa agctttttcg tttgaaaagt aagatacact gtatcagcta 1399981 catagggcct tacttatttg gcgttggtga aaagggaaca gtcattcgtt cggctgatga 1400041 agggaaaacc tggacgatgt cgagctttcc gacaaatgca acagtgtggg cgattaccgg 1400101 cagaaacaac gggtttgtct gcgcccacgg taagcattgt atttatgtat cggatgattt 1400161 tggtgtctca tggcgcgtag ccaaaccttt tgccgaattt cataatcccc ctgttatccg 1400221 gtcgttatgc cttcacgggg gcaatctctt tatcggcacg caaatacacg aatattttgg 1400281 cggcatttgg gcttacgaca ttaagcgtga cactgtccaa gttgtcaaaa aagaaaaaaa 1400341 ccggatgacg gcatccatgc tcgtgttcaa tgaaaattgg ctggtggcgg cgatgggttc 1400401 tgtgaaagga aagcacggtg ctgtcactgt aaggaatctt ttgaatggtg aagaattcac 1400461 catacaatcc agtatgatca gaaatgaaga atcatttctt gatctttcag aggatgatgg 1400521 cattatatat gtcactacaa cacaagatga aaatggtttt tcgagaattt accaggttga 1400581 tctcgaagcc cggtcgttaa aatggttcga taccattaag ggacatggat ggagagtggc 1400641 caatcagaaa gagaatttct tttgcgcagg cttgtatgaa tgtaaatttg tccagccgta 1400701 cgaagtttca gcaatgattc attagaggag gaacaaggaa ttggcgaaga ttttgctcgt 1400761 ttatgcaaca atgtcaggca acactgaagc tatggcagat ttgattgaaa aggggcttca 1400821 ggaggcgtta gcagaagtag accgtttcga agcaatggat attgatgatg cccagctgtt 1400881 taccgattat gaccatgtca taatgggaac ctacacgtgg ggagacggag atctgcctga 1400941 tgaattttta gatcttgttg aagacatgga ggagattgat ttttccggca aaacatgcgc 1401001 tgtattcggt tccggtgata cagcatatga atttttctgc ggagcggttg atacgctaga 1401061 ggcaaaaata aaagaacgcg gtggagacat tgtgctgcct tcggtaaaaa tcgaaaataa 1401121 tccagaaggt gaagaagagg aagaattaat aaacttcggg agacaattcg caaagaaaag 1401181 cgggtgcgct gtctgatcac tcactgggaa ctgctaaaac ggctgttcct ttttttcttg 1401241 tctttgtatc tttcctttga tacagtaatg aggtagaaaa tcaggaggag gactatacat 1401301 atgaaaatga tggacgcaaa tgaaattatt tcatttattc aaaatagtac aaaatctaca 1401361 cctgtaaagg tttacgtgaa aggtgagctg gaaggaatca atttcggtga atctgcgaaa 1401421 gcttttatca atggaaacac tggtgtcgtt ttcggtgaat ggagcgaaat ccaaacagca 1401481 atcgaagaaa accaaagcaa aatcgaagac tatgtggttg aaaatgaccg ccgcaattct 1401541 gcgatcccaa tgcttgatct taaaaacatc aaagcgcgta tcgagccggg tgcgatcatc 1401601 cgcgaccaag ttgaaatcgg tgataacgca gtcatcatga tgggtgcttc tattaatatc 1401661 ggttcagtca tcggcgaagg cacaatgatt gatatgaacg ttgtgcttgg cggacgagct 1401721 actgttggaa aaaactgcca tatcggcgcg ggttctgtac ttgcgggcgt tattgagccg 1401781 ccatccgcta aaccggttgt gattgaagac gacgtcgtaa tcggcgcaaa tgctgttgtg 1401841 cttgaaggtg taacagtagg taaaggagct gttgttgctg cgggagcgat cgtggtaaac 1401901 gacgttgagc catacactgt cgttgcaggc acaccagcta aaaaaatcaa agacattgat 1401961 gaaaaaacaa aaggcaaaac tgaaatcaag caggaattac gccagctgta aggaaaagtt 1402021 tgataaaaaa ggcgtggata atatatccac gccttattcg tataggcagg aggaatagaa 1402081 atgaagatag aggagctcat cgcaattcgc agagatctgc atcgtatacc ggagcttgga 1402141 tttcaggagt tcaaaaccca gcagtattta ttaaatgtct tggaacaata tccgcaagac 1402201 agaattgaaa ttgagaaatg gcgaacaggg ctttttgtaa aagtgaacgg gacggcgccg 1402261 gaaaaaatgc tggcatacag agcggatatc gatgcgcttt ctatagaaga gcaaactggt 1402321 cttccattcg catcagagca tcacggcaac atgcacgcct gcggtcacga tttgcatatg 1402381 acaattgcac tcggcattat tgatcatttt gttcaccacc cagtcaaaca tgatttgctt 1402441 tttctgtttc agccggcaga ggaagggcct ggcggtgcgg aaccaatgct tgagagcgat 1402501 gtattaaaaa aatggcagcc tgatttcatc actgcccttc atattgctcc agagcttccg 1402561 gtaggcacca ttgcgacaaa aagcggcctt ctatttgcga atacatcaga gctagtcatc 1402621 gatctggaag gcaaaggggg acatgcggca tatccgcatt tggctgagga tatggttgta 1402681 gcagcaagta cacttgtcac ccagctgcaa acgattatct ctagaaacac agatccgcta 1402741 gacagtgctg ttattacagt tggtaccatt accggaggct cggcacaaaa tatcattgca 1402801 gaaacggccc acctggaagg cacgatccgc acgctttctg aagaatcgat gaaacaagta 1402861 aaggaacgga ttgaagatgt agtgaaagga atcgaaatcg gattccgctg caaaggaaaa 1402921 gtgacatatc cgtctgtata tcaccaagtt tacaatacga gcggattaac agaagaattt 1402981 atgtcttttg ttgctgaaca tcaactggcg acagtaattg aagcaaaaga agcaatgact 1403041 ggagaggatt ttggctatat gctgaaaaaa tatcccggat tcatgttctg gctcggcgct 1403101 gattctgaac atgggcttca tcatgctaag ctgaatcccg atgaaaatgc gatagaaaca 1403161 gcggttcatg tcatgacagg ttatttttct gtttatgcca attaagtaca aatgaaagaa 1403221 taaaattcca taaaatgagc actctagtaa acggaggtgt tcaaaaatgg ctaaaaaaat 1403281 tggaattgaa caatcgttat cagatgtaga agctgcttta aaagaaaaag gatatgacgt 1403341 tgtaatgatg aaaagccctg ctgatgctca aggctgtgac tgctgtgtcg taacaggtct 1403401 tgataataat gtgcaaggga tagccgatac ggtaacacaa gcacctgtca ttacagcttc 1403461 cgggatgacg gctgaagaaa tttgtagcga agttgagagc agaattcagt aataaaaaaa 1403521 ccgaagcaaa aagcttcggt tcttttattt attctgtttc tttagggaaa gcgcggtcga 1403581 acgcgttctt tatttctttt ctcaacactc gttcgactcg ccactgttcc atattttctg 1403641 ttttggcaat gaccctgatt acaatttcag aagtccccag ttcttgaatc ccgatgacat 1403701 ttgggccttc ttttatttgt ggaagagccg ctgccgtttc atcacaaacc tgctgtaaaa 1403761 tatgaatcat ttcatcaata tttctttcag ccggcacttt aatgtcaaca agagcctgca 1403821 tggtaccacg agaatgattg ctcacgtttg tgatgtttct gttggggatg taatgcagtg 1403881 ttccgtcaaa gctgcggatt tgagttgtcc ttaagccaac ctgctcgaca attccgtcaa 1403941 aggtggaaac ggtaatataa tctccgacat ccaattgttt ctcaagcaaa ataaaaaaac 1404001 ctgtcacgat atcactgaca agcccttggg cgccaaatcc gacagccagg ccgacgattc 1404061 ctgcccccgc taaaagagcg cttggatcat aatgaaacaa atctagaacc atgacgaaaa 1404121 atatgaaaat caatgtataa gcaaatatgt taagagtcag gcttcggagc gtatgtgcac 1404181 gtccgataga caagctattc tgctcctcga attttgcaaa cagatgttta atgattttca 1404241 tgcctaatga tcgaacgata aaatagagca atatcataat ggcgagttta atgagcagaa 1404301 caccggcatt tgtaatcagt cccgcccaat catattgttt aataaagtcc atgttgagct 1404361 ccttttctaa ttgattgctg cacattgaga ctagttaccc tgtacatgac catgttaaac 1404421 gttttattca aaaatgtcga agccaaagac atacatgatt tgttaaaaat tgactcagga 1404481 aatctgcttt tatataatgg cattgcaata taactaaaaa tggttaatca ccctttattt 1404541 tcatgcgatt ttgaccttta agccaaacaa taaattggag ggatacatat ggcagaacgt 1404601 atggtaggta aacaagctcc tcgttttgaa atggaagcag tccttgcaag caaagaattc 1404661 ggcaaagtaa gtcttgagga aaacatgaaa aacgacaaat ggacagtgct gttcttctat 1404721 ccaatggact tcacttttgt ttgtccgaca gaaattacag caatgtctga ccgctatgac 1404781 gagttcgaag atcttgatgc agaagtcatc ggggtttcaa ctgataccat ccatactcat 1404841 ttagcttgga tcaatacaga ccgcaaagaa aacggtcttg gccagctgaa atacccgctt 1404901 gctgctgata caaaccatga ggtatcccgg gaatatggcg ttttaatcga agaagaaggt 1404961 gtggctttgc gcggattgtt tattattaat cctgaagggg agcttcaata tcaaactgtt 1405021 ttccataaca acattgggcg tgatgttgat gaaacgcttc gtgttctcca ggcgctgcaa 1405081 actggcggac tctgtccggc taactggaaa ccaggccaaa aaacacttta attctttcca 1405141 agaacgaaaa gcggtctagc atattcgtta ggcctctctt ttaaaatagg agggaaaaag 1405201 caatgaaatt acgtcagccc atgccggaat tgacgggaga aaaagcttgg ttaaatggtg 1405261 aagtgacgag agagcaattg attggggaaa agccgacgct tattcatttc tggtccatca 1405321 gctgccactt gtgcaaagaa gcgatgccgc aagtgaatga atttcgtgat aaatatcaag 1405381 atcagctgaa tgttgtagct gtacacatgc cccgttccga agatgatctt gaccctggta 1405441 aaattaaaga aacagctgct gaacacgata tcactcagcc gatttttgtt gacagtgacc 1405501 atgctttaac cgatgcattt gaaaatgaat atgtacctgc atattatgtg tttgataaaa 1405561 caggacagct ccgtcacttc caagccggcg ggagcggtat gaaaatgctt gaaaaacgtg 1405621 tgaaccgcgt tctggctgaa acggaatagg tatctgacta aatagtattt cctaaaaacc 1405681 tgacctcatc aggtttttta tttgtgcaaa aagcaatgga agaagagtaa gaagcttatt 1405741 tttccaaatt tgggtatagg aattgatgat ttgtttgatt gatacgctaa aaaacacagc 1405801 taatttttga tgtttttcct caattttaga taaatctcat atctcataac tcgaaaattg 1405861 tagatattac actaaatttc tttaaagaag taagtaaaat atatattttc aacattatac 1405921 caaataaact agaaagcccc ttaatccctt gagaataaag gactcttttg aaaaataaaa 1405981 cattttcaga aaataaggaa tttttcatag agtaaatata atagtaaaat gctaaaataa 1406041 tagttgataa aattactttt gtaatctaat atcttaatta aagatgttaa ttttgatagg 1406101 gggtacattg aggaatgttt aatgaaagag aagctttgcg cttgcggtta gaacaattaa 1406161 atgaagctga agtgaaagtc attcgtgaat atcaaattga acgtgataaa atatacgcaa 1406221 aattaagaga gctggacaga aatggaagcc cttccgaaat caaaaaggat ttccgttctg 1406281 aaaaaaaacc tgactctctg ccggttctcg ctgagcttgc ggctcaggaa atcagaagct 1406341 atcagccgca atcacagcag cagtctgttc agcctcagct tcaatctatt tcctctcttc 1406401 ctgccggtat accagacgga acaacacgaa gaagaagagg aacggcaaga ccgggatcaa 1406461 aagcagctaa gctgcgtgaa gctgctatta aaacattaaa acgccacaac gcggcgatta 1406521 agagctcgga gcttcaaaaa gagattgaaa aagaaagcgg tcttgaaatc cctaatatga 1406581 caacgtttat gcaaagctta attaaaatgt acccggaagt gaaaaagcca tatcgcgggc 1406641 agtacatttt agagggtgaa atcgaatctg cagaatcagc aaacgaataa atataaagaa 1406701 aaactgcttg gcatcgctca agcagttttt ttattgaggt tttttctgtg aaggtttgtt 1406761 ttctttttca agattaagct tatacaccca cttttgataa ggcttttctt cagcggctct 1406821 gtttttcagc tcttcgattg tatggctctt ggcctggtct gatgattggg cgtgggcaag 1406881 ctgtttttga agcacatgta tctgtttggt gacatcttca aggatagtct ctacatgatt 1406941 tggctgcgcg taggccgctg gagcttcttc ttccgttttt tctttttgtt tcgtgccgcc 1407001 atcaatatcg gcaaaatgag aagcaatcca ggcatcgctt tcatcaagtt gccgtttata 1407061 cgatataata gtttcgtgaa ataatttttc tttcgttttt tctatgtcta gcagtctttc 1407121 tttcgtttct atgattcgat ctttcatatg atcaacttct attttaatat gttttagctg 1407181 atattctttt tctaccattt gctcttttag acgcccgttt tcggctttta tcaattcggc 1407241 ttgctgtttt gcctgaagca gtgcattttg ttcctgctca attgaggctt gaagttcgct 1407301 gatccgttta tgaagatttt tattttcttc ttcgattttg actttcgcaa tatgaagttt 1407361 atgtttttct tcgatttcgg ctctgcgttt ataggtttca gcagatagaa gctcctgcaa 1407421 aacaacgatt ttatcaagca gttcagctct tatttggtgc agggtttggc tggtgtggga 1407481 ggcatgtttt tcttttgttg acatatgtgt taattcggca gacagctgct ggagtttttc 1407541 tttcatatcg gtattttctt tgagcagttt gttatttttc tgatgaaagt agcttgcttc 1407601 aagttcagaa atcagcttat ggcaccttga aagctcggat tttaaataaa ggttctcctg 1407661 agacacgtcg tggaaaaaag gacctgatct tttcattcga accatctccc tcatgatgtt 1407721 aacactacaa tatgcaaata ctgaacagct attcctcttt aataaacaga caagcagtag 1407781 cgttgagcct ttgcttttgc tatgctttta acgaaactag aggtgagatg atatgaagca 1407841 tgtaaacgta ctgctggcag ggggagcctc acgtcgcttt ggagaaccga aggcgtttgt 1407901 caaatggaag ggcaggatgc tttacgaatg cgctaaagag gcacttggag aacaaacggt 1407961 tatcatcagc cgtcccgaat ttattgatag atttcaagaa aacggtgaaa atgaagtgta 1408021 tcaagatgct gagccatttc aaggcatggg gccattggct ggtatatata ccgcttttaa 1408081 aaagacagac ggtgatcttt atactgttct ttcctgtgac acaccgctga tacaaagaag 1408141 gacgatgctg gagctcaaac gtctgatgat tgccggtgcg gacgcggtag tcccaatttc 1408201 agacggacaa gtgcagccat tgattgcgat ttaccacaaa cgtatcatgc cagttctata 1408261 cgatcagctt tctgagaaga ggttgagaat atcagattta ttaggcagaa tttcggtttg 1408321 ttacgtacag gctgaaaata tcggagcaaa cccggcagag tttatcaaca ttaatacacg 1408381 tgatgatttt agctgtttgg aagaaaaatc gaactccctc aagcgggact gacggggcaa 1408441 taacatgata agatgacata aaagataagg agaacaggtt tgatggagga acgttattca 1408501 cggcaaatca gatttaagca aattggggaa gagggccaga aaagactggc agacagccat 1408561 gtgctgattg tcggagcggg agcgctcggc actgcaggag ctgaagggct ttcgagagcg 1408621 ggagtcggta cgattaccat tattgaccgt gactatgtgg agtggagcaa tcttcaaagg 1408681 cagcagcttt atacagaaag cgatgccaaa ctccgcatgc cgaaagccat ggctgccaaa 1408741 gagcatctat cagcgattaa cagcgagata catattgagg cgtatgttac cgaaggaaca 1408801 gccgaaacgc ttgagccgct gattgaaaaa gcagatgtcg tgatcgacgc gacagataat 1408861 tttgaaaccc gcatgctgat aaacgatctt gcccagaaaa caaagacacc ttgggtctat 1408921 ggcgcctgtg taagcagcca gggaatgttc atgactgtca ttcccggaga aaccccttgt 1408981 ctgtcttgtt tgtttgagca aattcctgtc ggcggggcga cgtgtgatac tgccggcatt 1409041 attccgcctg ctgtgcatat cgtttcagca tatcagcagg ctgaggcatt aaagctgtta 1409101 accggccaaa aagaagcaat acagcggggg tttgtgacat ttgatgtctg gaacaattcg 1409161 catatgaaga ttaacgttaa tcatgtacgc cgtgaggaat gcccatcttg cggagctaat 1409221 gcggtatatc cttatcttca ggattggaac acaccaaaag ctgctgtact atgcggccgt 1409281 gatacagtgc aggtaaggtc agaatcatta aaaagaatcc cgaaacagga gctcattaag 1409341 cggctgaaaa caatcggcaa ggtcgaggct aatgcgtttt tgctgcatat tttttacgag 1409401 gatttcagaa ttgtcatttt caatgacgga cgggcactgg tgcatggaac aaatgatgtg 1409461 aaagaagcca actccgtgtt ggcaagagtg attggactgt aacaacagga ggggtcagaa 1409521 tgctggagaa aagaacaccg ataccggtag acgaggcagt tcggcgtgtc tgccattttc 1409581 aaaaacaagg tgaaacagaa tgggtggcgc ttgaagacag ccttcatcgg tttttagccg 1409641 aagatataac tgcggatcac cacgtacctg cgtttgaccg ttcgccatac gatggttttg 1409701 ctgtcagagc gtgcgatacg gcagaagctt cacgtgaaaa cccagttcgg tttgaagtta 1409761 ttgaccatat tggagcggga gcagtatctg aaaaagaact tggcccgttt caggccgtgc 1409821 ggattatgac tggcgcgcaa atccctgaag gggcagatgc agtcgtcatg attgaactga 1409881 ctcaagcctt tgaggagaat gggaagtcat ttatgtcttt aaaacgccgc tttcagacgg 1409941 gggataatat ttcaaaaaca ggtgaggacg ctcaaaaagg gagtgtttta ctgacaaagg 1410001 gcacccgggt gacaccagga gtgacggctc ttttggcaac attcggatac gcatctgtgc 1410061 ctgtcgtgag aaagcctgta gtcgggatta tcgcaaccgg taccgaattg ctgaatgtca 1410121 gtgatccgct ggaaccggga aaaatccgca acagcaatgc gagtatggta tatgcgcaag 1410181 cgatagaagc aggcgcaaca ccgctttatt tagggaaaat ctctgatgaa ctggataaaa 1410241 gctttgctgc agttaaagaa gcgatgaaaa aggtggactt cctgatcaca actggcggtg 1410301 tgtcagtcgg tgactttgac tttttgcctg cgatctatga aaaactcgga gcggacgtgc 1410361 tgtttaataa agttgccatg cgcccgggca gcgtgacaac ggtggcgcat gcaaacgata 1410421 tgctgctgtt tggcctttca ggtaatccgt cggcatgcta tgtcggtttt gaactgtttg 1410481 tcaaaccgat aatccagaca tggctgctca atgaaacacc gcattcaatt tgtgcggaag 1410541 ctgttttgac caaggatttt ccgaagccga acccatttac ccgatttgtt cgtgcgctcg 1410601 tgcaccatca ggaagggaag ctgttggcga cacccgttgg cttagataag tcgagctctg 1410661 tcacatcact tgcagatgcc aatgcattta ttatcctgcc gggcggtacg cgaggctacg 1410721 aatctggcag aacggttcaa gtgctgctca tcagagaaga gaatggaagt gaatggcctt 1410781 ggtccgtcct ttcccgatcg tccaagttgt aggatttcaa aacagcggga aaacaacgtt 1410841 tattgagcgc attcttgaaa aagcctctga acagggagtc catttgggct gcctgaagca 1410901 ccatggtcac ggcggtgaac cgcaaacgct cacggaagga aaagacacgg accgttacaa 1410961 ggcggcaggt gctgatgtaa cagcggtaga aggtgctggt gtgttacagc tgactgcccg 1411021 ccgcaattgg gatttggcac ggctgattga gttataccaa tttctcgaaa cagactgtct 1411081 tctgattgaa ggctttaaaa aagcccctta tcctaaagtg gttatcctaa gtgaaaagga 1411141 agatctggaa gcgctgcaag cagtaaatat aatcgccatc atctatagaa aaaaagagca 1411201 tatgacagag catcagggat tacccgtttt tcatgcggat gatccggttg ccgtggattt 1411261 tgtgctttca cagctgaagg gggaatctgc ataatggaac ggtttgagat tacgaaaaca 1411321 cccattaata ctgaaaacat catcaaaaaa gtggagaaac gggaagcggg agccattaca 1411381 acatttattg gtacggttcg ggaatggaca aacggaaaaa gaacggttcg gcttgaatat 1411441 gaggcatatg aaccgatggc cgtgcaaatg cttgctcaaa tcggcgctga aatcgaagaa 1411501 aaatgggaag gtgcctcagc tgcgatcacg caccgtatag gtgtgctcga tatcggtgaa 1411561 gcagcggtag tgattgctgt atcttctccc catcgaaaag ccgcatatga agccaatgag 1411621 tatgcgattg aacgcattaa acagattgtg ccgatttgga aaaaagaaat ttgggaagac 1411681 ggtgagcaat ggatcggcga ccagctagaa acgacagctt atccgaacgg aaaaccagac 1411741 ctaagcgagg gagagcagca tgattaaaat tcttttattt gcagggcttg ctgaacaggc 1411801 cggtacacaa gcaatagaaa tagatatgga acaagcaacc acagatgaaa taaaagcgag 1411861 tctaaaagaa caatacggtc ttgaatctat tgatacggct atgattgccg ttaacgaaag 1411921 ctatgtaaaa gaaaatacct ctgtatcttc gggtgacacg gtagccatca taccgccggt 1411981 cagcggggga tgaaaaccgg acggcatttc agccgtccgg tttttctgta tttcattggc 1412041 atatccccaa gtatcctcag catacaatga ttttctgtaa gcgtttattc tacatatgtt 1412101 actccctata aagtaagaga ctcactccat aattagactg aaattttgaa aaataataga 1412161 aatttatttc gggtatcgat atagtgaaga tgataaatgt tggaaaggtg ctggatatgg 1412221 agacatttaa aagattaaaa atgtattatt ggccgtacag aaaagtgttt atgtggtcgc 1412281 ttctagccat gcttttgatg actgcaatta ctgtcgttta tccgattatc ctgcaaatta 1412341 cgattgatga gatcgtactg ggacggcagt atcagcttgc ggcgtgggtc agcttaggat 1412401 ttattgcggt gatggttttg aaaggaatgg ctaccttttt tcatcagtat ttaggtgata 1412461 tgttcgggat caaatccgtt tatcggctga gaaatggtct gtatgaaaaa ctgcagcggc 1412521 tttctttttc ttactatgat aacgcgaaaa caggagattt gatgtccagg ctgactgctg 1412581 atgttgaagg gcttcgtttt ttcttatcat acggtctcgc tgagctcatt cgcttcggcc 1412641 tgctggtagc catcagcctg tcggttatgt tttactattc tgttcctctc acgcttgtga 1412701 caatagctgt tctgccattt ctcgcggttg cggtataccg gtttgacaaa agagtccatc 1412761 ccgccttcag aggcatccgc aaatcgtttg cgaaactcaa tacaaaagtt caggaaaata 1412821 tcagcggcat taatacggtt aaatctcttt ccagggaaga ttttcagatc agcactttca 1412881 ataaagccaa tgcagaatac agggcgcagt atttacaaac atcatccatt tggtctgcgt 1412941 atttcccttt aatggagttc attggtaaca cttgtattgt agctcttctc tcatacggcg 1413001 gttacttggt tatgcaaaat cagctcaatc ccggcgagct tgttgctttc ttcagccttg 1413061 tcaattatat gatgtggccc attatgaact taggttttgt catcaatatg ttctctcaag 1413121 caaaagcgtc aggggaacgc ctgctcgaca ttctggaaaa agaagaagac attacagatc 1413181 atcctcatgc tttgcataaa caaaaattaa ccggagatgt ccatttcaaa aatgtttctc 1413241 ttgcatacgg aaaagaacaa acaaacgcgc tgtgcaatgt aagctttgag gcaaacagcg 1413301 ggaaggtaat cggactgttg ggcccgacag gttcaggcaa aagctcagtg acacagcttc 1413361 tcaccagatt ttacagtcct gttggcggaa tgattaccat tgatcacaaa cccatcacag 1413421 attattcgtt aaaaaccctt cgctccaata tcggggtcgt acttcaagaa tccttcctgt 1413481 tttcatctac gattagatca aatatttcgt atgggcggcc ggatgcctca atggaagacg 1413541 tcatcgaagc ggcaaaaagg gcgcaggctc ataactttat tatggagctt cctgatgggt 1413601 atgacaccat gctgggagag aggggaatgg ggctttccgg cgggcagaaa cagcgtattg 1413661 ccattgcgag agccatctgc ttgaacccga gcattttaat attggatgat gccacaagcg 1413721 cagtagatat gcaaacggag cacagcatac agcttgcctt aaaagaagtc atgaaaaacc 1413781 gcacaacctt tatcgtcgct caccgcattt cttcactgaa acacgctgat gaaattctcg 1413841 tttttaataa aggacgcatt cgtgaaaggg gaacacatca tgagcttctt gaaaaaggcg 1413901 gctactataa aaagatttac gatttgcaat accgtgatgt caaaatgatt aatgagccgc 1413961 atgaggtcgg atagggaggg gccaaatgaa acaagcgaaa aaacaggggg ttttagagcg 1414021 tttctattac tcttcagatg aaatcattga aaagccgttt aactgggctc aaatgtggcg 1414081 gctgctgagc tatgtcaaac catatcgaaa aacaattttg ccgctttctt ttctcactgt 1414141 attgattggc actgctgtga agcttgtgat ccccattttg atcggcgttt atgttcttga 1414201 tcaagcgatt acagggagaa actcggagct gctgattcag ctcattttta ttattagcgg 1414261 tttatatgtc ctcaattacg ccgccaatgt gttaagaatc aggtggatga atcagcttgg 1414321 ccagcatgtc atttacgatt tgcgacagca tttatttacc catgtgcagc gcttatccca 1414381 tcgatttttt gatcagcggt cggcgggatc gatcttagtc aggatcatga atgatattaa 1414441 ctctcttcag gagctcttta caagcggagt catcaatttg ttgaccgact tgctgcttct 1414501 ggccggcgtg attattattt tgtttacgct gagccctgag ctgactatag ccatcatggt 1414561 gacattgccg attatgtttt ttatttcaac aagtctcaga aaaaaaatac gccgatcctg 1414621 gcaaacggta cggctgaagc aatcgaagct caactctcat ctaaacgaaa gcattcaggg 1414681 catccgggtc acgcaggcat ttacgcagga agaagaaaac atggcgtatt ttgacggtgt 1414741 caatcaggag aactacgaat catggcggga agcaactaga aaaaatgcca tgttccgtcc 1414801 gcttgtagaa atgacgaatg cgattgggac ggctgtcttg atttggtatg gagccacact 1414861 catcatgaat gaaaccatta cgattggcgt cttcgtttct tttgctttct atctgggaat 1414921 gttttgggaa cctatttcga gactgggtca ggtctataat cagctgttaa tggggatggc 1414981 atcatcagaa cggatttttg agtttctgga cgaacagcca aatgtcaagg agaagccgaa 1415041 tgccattcat aatgaaaaga taaatgggga gatcagtttt gaagaggttg aattttcgta 1415101 tgatgaaaaa cgaaaagccc ttcacgccgt ttctttctct attcctgcgg gatcgacgct 1415161 tgcgcttgtc gggcatacag ggagcgggaa gacgacgatt gccaatttaa tcagccgttt 1415221 ttatgatgcg gccggaggca ccattaaaat agacggtata ccgattaagg atctttccct 1415281 tgccagtctg cgctctcaaa tcagcattgt cctgcaagat acatttattt tctccgggac 1415341 catcatggaa aatattcgtt ttggaaggcc aaatgcttcg gatgaagagg tgatgaaagc 1415401 gtcccaagcg gtcggagcgg atgagtttat ttccgattta gcggaaggat acgcaacaga 1415461 ggtagaggaa aggggcagcg tactgtctgc cggtcagcgc cagctcattt catttgcaag 1415521 agcattgctc gccgatccgg ctattatcat ccttgacgaa gcaacggcaa gcattgatac 1415581 agagacagaa gtaaaaattc agcaagcgtt aaaaacgctt ctgaaagggc gtacagcagt 1415641 gatgatcgct cacagattgt ctacgatccg cgacgccgac cgcatcattg ttcttgatca 1415701 cggcaggaaa atagaagaag ggaaccatga tcagctgctc gctaaaggag gcatttatgc 1415761 cgggcttgtg aaagcgcaat acagcacagc gatagaataa tatgaaaagc cttcaatatt 1415821 gaaggttttt ggaaatttat tagaaaaaca tgaaactttt tgatatcctt cccgtactat 1415881 ttgttagata ttctcaagga ggttttgaaa tggaaacgaa tgtagaaaaa aacagcggaa 1415941 cggcgactga aaagccttca cttttcggag taatcacaag tccgtccgtt caatttgaaa 1416001 gaataagaga aaggccggct gtatggggac cgcttttgat tgttgcagca attatcatcg 1416061 tcggtgccgt gctgcaatca ctcggtacgg attatagtga gcttttgaaa agccaggata 1416121 cgcaagggct atctgctgaa caaatggaaa ctgtcgcaac aataaccaaa tttggcggaa 1416181 tggcaggcgc tattatcggc ggtatcgcag cattatttat tgcccctctt atttattggc 1416241 tctgtgtaaa agtatcaggc ggtgttacga catataaaaa aatgctttct ctcagtctgt 1416301 ttgtctcttt gattagcagt ctcggattat tggttaatgg aatcgttgct tttacgactg 1416361 acgtgaatcc tctttacagc acgacgtcac tcgcagggat tatcccatct gacggggctc 1416421 tcgccagtgt gttaaatacc tttgaaattt tcagcatctg gagctttgta ttattagcaa 1416481 tcggacttca caaaacggga ggcatctcaa aaaaagccgg gtggatttca gcaatcattc 1416541 tattcggaat tttagttgta ttttcgcttt tttcaggttt aatcaattct gtggcgggtg 1416601 cataagctca tgaaaaaagt ctggatcgga attggaatcg cagttatagt cgctcttttt 1416661 gttggaatca atatataccg gtctgccgct ccgacaagcg gcagcgccgg caaggaggta 1416721 cagacgggga gcgttgaaga aaatgaaatc tcatcaacgg ttatggttcc tggcacgcta 1416781 aaattttcaa atgaacagta tgtcttttat gaagcggata aagggacatt agaagacatt 1416841 aaagtaaagg aaggcgataa agttaaaaag ggcacggctt tagtcaccta tacaaatgag 1416901 cagctgagcc tggaaaaaga acagaaccag ttaacgtctg aatccaaccg gcttcaaatt 1416961 gaccaaattc aagaaaagtt aaaagccttg gacagcaaag aaagagaact ggaaaaacag 1417021 gtaggaaaga aagaagcaga aaaacaaatc gaatctgaac ggacagagct tcaaatgcag 1417081 aaaaaaacag cggagatcga attaaaacaa accgagcttc agcggcagtc acttgccaac 1417141 cgggtgtcag atttagaagt gaaaagcgaa attgaaggca ccgttatttc tgtcaaccaa 1417201 gaagcggcat ccaaaaagtc agatattcaa gagcctgtca tacatatcgg caacccaaaa 1417261 gaccttgtcg tctcagggaa attgtctgaa tacgatacat tgaaagtcaa aaaaggccag 1417321 aaggtcacac tcacttcaga tgtaatacag ggtaaaacat ggaaaggcac ggtttccgca 1417381 gtcgggcttg ttccggatca gcaggagagc gctgcggcac aaggaacaga acaggcggtc 1417441 caatacccgc ttcaagtgaa aataaaagga aatcttccag aaggaaagcc aggctttaaa 1417501 tttatcatga atattgaaac agataaacgg aaagcaaata cgcttccttc aaaggcagtc 1417561 aaaaaagaag atgaccaata ttatgtgtat acagtaaaag acggaaaagc aaagcgagtt 1417621 gatgtcaaaa tcggcgaagt gacagatgac ctgacagaaa ttaaagaggg gcttacccaa 1417681 gatgatcaag tcattttgaa tccatctgat caggtgactg acggaatgga agtgaaatcc 1417741 taaatgattc agctttctaa tgtgcgaaaa agctaccaga tcggaaagga aacgtttgat 1417801 gttctccatt ctattgattt ggacattcat caaggtgaat atgtctcgat tatggggccg 1417861 tcaggatcag gaaaatcgac gatcatgaat attatcggct gtcttgatcg gccgacttcc 1417921 ggtacatatc aattggacgg cgaagacatt tcttcatata aagataaaga actggcggca 1417981 gtccgtaacc ggtccatcgg ttttgtattt cagcaatttc agcttcttcc gcggctgaac 1418041 gcaaaaaaaa atgtcgagct gccgatgatt tattccggga taggcaaaaa ggaacgtcaa 1418101 gagcgggctg agagagcatt ggaaaaggtc gggttagccg atcgaatgct ccacatgccc 1418161 aacgagctgt cgggcgggca gaagcagcgg gtggcgattg cgagggcgat cgtgaatgag 1418221 ccgaaattga ttttagctga tgaaccgacc ggcgcgctgg atacgaaaac aagcgaggcg 1418281 attatggatc agtttacagc attaaatgcc gagggaacga caatcgttct ggttactcac 1418341 gagcctgaag tagcagattg cacgaatcgg atcgtcatgg tgcgtgacgg aaacattgtt 1418401 cctgccagct ccggacaaag gagtgtggga gaatgagcct gttggaaaac atcagaatgg 1418461 ctctaagctc tgtccttgcc cataaaatgc gttcgatctt aacgatgctc ggcattatca 1418521 ttggtgtagg ctctgtcatt gttgtcgttg cggtaggaca gggcggcgag caaatgctga 1418581 agcagtcgat cagcggcccg ggaaatactg tggagctgta ctatatgcct agcgacgagg 1418641 agcttgcaag caacccgaat gccgcagctg aatctacgtt tacagaaaac gatattaaag 1418701 gtttaaaagg aatagaaggc attaaacaag tcgttgcttc gacttctgaa agtatgaaag 1418761 cgcgttatca cgaagaagaa accgatgcta cggttaacgg aataaatgat ggatacatga 1418821 atgtcaattc tttgaaaatc gaaagcggca gaacctttac cgacaatgac tttctcgcgg 1418881 ggaatagagt cggaatcatc tctcaaaaaa tggctaaaga gctgtttgat aaaacctccc 1418941 ctctaggtga agttgtctgg attaacggac agcccgttga aattatcggc gtgctgaaaa 1419001 aagtaacagg cttgctttct ttcgatttaa gtgaaatgta tgtgccattt aatatgatga 1419061 aatcctcttt tggcacaagt gatttcagta acgtatcatt gcaggtcgaa tcagcagacg 1419121 acataaaatc ggctggaaaa gaagcggcac agctggtaaa tgacaatcat ggcacagagg 1419181 attcgtatca agtgatgaac atggaagaga ttgcggccgg aattggcaaa gtaactgcaa 1419241 ttatgacgac gattatcggc tcaattgcag gtatttccct tttggtcggc ggaatcggtg 1419301 tcatgaatat tatgctcgta tcagtcacag aacggacgcg ggaaatcgga atcagaaaat 1419361 cacttggtgc gacgagggga cagattctga ctcagttttt aattgaatca gtcgtattga 1419421 cgctgattgg cggtctggtc gggattggta ttggatacgg aggggccgcg cttgtttcag 1419481 ccattgcggg ctggccgtca ctcatatcct ggcaggttgt atgcgggggc gtgctgttca 1419541 gtatgctcat tggtgttatt ttcggcatgc ttcctgcaaa taaagccgca aagcttgatc 1419601 ccattgaagc gctgcgttat gagtagcctc atgcaacatg catgaggttt ttttatgttt 1419661 agtgatttct actatgaata taaaagactt ttttcattaa aataagaaga aaatgtcgta 1419721 caattgtcct tatttttgtc gaatttacag tttacaaacc ctatagacat acgttaatat 1419781 ggagaaacgt gaaagatttt gatagttatt gaatgaattt gaatgatttt agttgcctaa 1419841 accgaaaata gcgtttacaa tgaaattgta ttcaaaatga atacgttttc attaggaggt 1419901 gaagcatgct aactcctgaa cggcatcaat tgattattga tcaaatagaa aagcatgatg 1419961 tggtaaagat tcaagagctt ataaatctga ctaatgcttc tgaatcaaca atcagaagag 1420021 atttatcgac ccttgaagaa cgcggttttt taaagcgcgt tcatggtgga gcggccaagc 1420081 tttccgatat cagacttgaa cccgatatgc ttgaaaaatc atccaaaaac cttcacgata 1420141 aactgaagat tgctgaaaaa gctgcttctc ttttagaaga aggggattgc atttaccttg 1420201 atgcaggcac gacgacattg cacatgattg attttatgga taaaaccaaa gatattgtcg 1420261 ttgtcacaaa cggggtaatg catatcgatg cattaataag gaaagaaatt tctttttatc 1420321 tgcttggagg atacgtaaag cacagaacgg gcgcgattat tggaggcgct tcattggttg 1420381 ccatggacca gtacagattt gacaagagtt ttctggggac aaacggtgtc catacagagg 1420441 ctggatttac aacgccggac cctgatgagg cccttttaaa acagaaagcg atcaaacagg 1420501 caaaacacgc ttacgtctta gcagaccctt cgaagttcgg agaaatttca ttttcggcat 1420561 tcgccggaat aggcgacgca acaatcatta cgactgacgc tgaagagctt acattcgata 1420621 attaccaaga aaaaactgtc gtaaaggtag tgaaaccatg atttacactg taacacttaa 1420681 tccatctgtc gattatatag ttcacgttga agattttact gtaggaggcc tgaaccgttc 1420741 ttcgtatgat accaagtatc cagggggcaa aggcatcaac gtatcgagac tgctgaaaag 1420801 acaccatgtg gcgtctaaag cgctcggatt cgtcggcgga tttaccggag aatatatcaa 1420861 aacattttta cgggaagaaa acctggaaac agctttttct gaagtaaaag gggatacccg 1420921 tatcaatgta aagctgaaaa cgggtgatga aactgaaatt aacgggcagg gaccgacaat 1420981 ttcggatgaa gatttcaaag cctttttaga acagttccaa tctttgcaag agggagatat 1421041 cgttgttctt gcaggaagca ttccatcttc actccctcac gatacttatg aaaaaatcgc 1421101 agaggcctgc aaacagcaga acgcacgagt tgttctggat atctcaggcg aggctctttt 1421161 gaaagcaaca gaaatgaaac catttttgat gaagccaaat catcatgagc ttggagaaat 1421221 gttcggcacg gccattacat ctgttgagga agccgttcct tatgggaaaa agcttgtaga 1421281 acaaggcgct gaacatgtaa tcgtatcaat ggccggagac ggagcgcttc tgtttacgaa 1421341 cgaagctgtt tattttgcta acgtgccaaa ggggaaattg gtaaactcag tcggagcagg 1421401 ggattccgtt gttgcaggtt tccttgccgg aatttccaaa cagctgccgc ttgaagaagc 1421461 attccgctta ggagttactt caggcagtgc taccgcgttc tctgaagaac ttggaacaga 1421521 agaatttgtc cagcagcttc ttcctgaagt taaggtcaca cgtctataga ggaggaaaca 1421581 caagtgaaaa taactgagct tttaacgaag catacgataa agcttaatat tgagagcaaa 1421641 gaaaaagaaa atgttattga cgaaatggtc actgttcttg ataaggctgg aaagttaaat 1421701 gaccgacaag cctataaaga agccatttta aatcgcgaaa gccaaagctc cacgggtatc 1421761 ggtgaaggaa tcgctatccc ccatgcgaaa acggcaagcg ttatcaaccc ggcgatcgcg 1421821 ttcggacgtt caaaagacgg cgtcgattat gaatcattag acggccagcc ggctcactta 1421881 gtgttcatga tcgcggcgac tgaaggcgca aacaacactc accttgaagc attgtcaaga 1421941 ctttcaacgc tgttaatgcg tgaagaaatc cgtaagcagc tccttgaagc tgagtctgaa 1422001 gatgccatca tcgacattat taatcagcac gataaagatg atgacgaaga ggaagaggaa 1422061 gaagaagcgg caccagcacc tgccggaaaa gggaaaattt tagcggttac tgcatgcccg 1422121 acaggtattg cccatacatt catggctgcg gatgccctta aagaaaaagc gaaagagctt 1422181 ggtgtggaaa ttaaggtcga aacaaatggg tcaagcggca ttaagcacaa gctcactgcc 1422241 caagaaatcg aagatgcacc tgcaatcatt gtcgcagcgg acaagcaggt tgaaatggaa 1422301 cgttttaaag gcaagcgcgt acttcaagtt cctgtaacgg cgggtatcag acgtccgcaa 1422361 gagcttatcg aaaaagcgat gaatcaagat gcgccgattt atcaaggcag cggcggcggt 1422421 tcagcagctt caaatgatga tgaagaagcg aaaggcaagt ctggaagcgg tatcggaaac 1422481 acgttttata agcacctgat gagcggtgtc agcaacatgc ttccgttcgt agtcggcggc 1422541 ggtattctcg ttgcgatttc attcttctgg ggaattcact ctgctgatcc gaatgatcct 1422601 agctacaaca cgtttgcagc agcattaaac tttatcggcg gcgacaatgc attaaaactc 1422661 attgttgcag ttctggccgg tttcattgcg atgagtattg cagatcgtcc tggttttgcg 1422721 cctggtatgg tcggcggatt tatggcaact caagcgaatg ctggattctt aggcggctta 1422781 attgccggat tccttgccgg ttatgtcgtg attttactga aaaaagtatt tacgtttatc 1422841 cctcagtcac ttgatggatt aaaacctgtt ttgatttacc cgctgttcgg tatttttatc 1422901 actggcgtat taatgcaatt tgtcgtcaat acacctgtag cggcatttat gaatttctta 1422961 acaaactggc ttgaaagcct tggtactgga aaccttgtgt taatgggtat tatcttgggc 1423021 ggcatgatgg cgatcgatat gggcggtccg cttaataaag cagcctttac gttcggtatc 1423081 gccatgatcg atgcaggcaa ctatgcgcct catgcagcaa tcatggccgg cggtatggtt 1423141 cctccgcttg gtatcgcact tgcaacaacc attttcagaa acaaattcac tcagcgtgac 1423201 cgtgaagctg gtattacatg ctatttcatg ggagctgctt tcgtaacaga gggagcgatc 1423261 ccatttgctg cggctgatcc gcttcgcgtc ataccagctg ctgtagtcgg tgcagctgtt 1423321 gccggcggat taactgaatt cttccgagta acgcttccgg cgcctcatgg aggagtattc 1423381 gtagctttca ttacaaacca tccgatgctt taccttttaa gtatcgtgat cggtgctgtc 1423441 gtgatggcaa ttatcctcgg tatcgtcaaa aaacctgtta cagaaaaata agaaaaaaag 1423501 cgtccttggt tcgaaaggac gctttttctt atccggccgg cagggagcgc ggttaagtta 1423561 tgtattttat tcttttttat gataaagtaa aagaagagaa acaactgaca tagcaattgt 1423621 ctaggaggaa acactttgac cgaggaaaaa aatacgaata ctgagaaaac ggcgaagaaa 1423681 aaaaccaata cgtacctgga atggggtaaa gcgattgtca tcgctgttct gctggctctc 1423741 ctgatccgtc actttttgtt tgaaccgtat ttagttgaag gttcatctat gtatcccaca 1423801 ttacatgacg gagaaaggct gtttgtgaat aaaacagtca actatatcgg cgagctgaag 1423861 cgcggagata tcgttattat caacggtgaa acttctaaaa tccattatgt aaaaagattg 1423921 atcggaaagc ctggagaaac cgttcaaatg aaggatgaca cgctttatat aaacggtaaa 1423981 aaagtagccg agccttactt gtctaaaaac aagaaggaag cagaaaaact tggtgtcagt 1424041 ctgacaggag actttggacc ggttaaggtt ccgaaaggca aatactttgt catgggagat 1424101 aaccggctga attctatgga cagccgaaac gggctgggac tgatcgcgga agatcgaatt 1424161 gtcggcacat cgaagtttgt ctttttcccg tttaacgaaa tgcgtcaaac aaaataaaaa 1424221 cgccttgctg gcctaggaca gcaggcgttt ttattttgaa aaagaagcga ccaatgcaat 1424281 gcataaaacc gtgatgaaca ctgaaccgat aatagccagc acactgaaga aaaggtgaac 1424341 ctgtttgttc tcttttccgc gcttttctaa tagccgttta gaaaaaatgt gcgaaaatat 1424401 gtaaataagg gctatgccta tatataagcc gatatctttg gcggtaaagc ctgttacggc 1424461 aaggtaaaag cccgtaaaaa agatcagtaa gcaatattca gtaagtgtta aaagcctcaa 1424521 cgtgttcctc catgagagtg tgtaattttc caggcggatg cattctctct ctttaattgt 1424581 aacacagctg gctggtttgg gtgtataagt gttttctctc tgttttatca gggaatcatt 1424641 tctcttgccc tgcattcatg gtatactttt attgatgata gacatgatgg aggataataa 1424701 atgattgctg taaataatgt aagcttgcgg tttgcggatc gcaagttatt tgaagatgtt 1424761 aatattaaat ttaccccagg caactgctat gggttaattg gtgcaaacgg tgccggtaaa 1424821 tcaacgtttc taaaggtgct gtcaggcgaa atcgagcctc agacaggcga cgtgcatatg 1424881 agtcctggcg agcgtcttgc cgtcttgaag cagaaccatt ttgagtacga agagtatgaa 1424941 gtgctgaaag tggtcattat gggccacaaa cgcctgtatg aagtcatgca ggagaaagac 1425001 gctatttaca tgaagcctga tttctcagat gaggatggga ttcgtgctgc tgagctagaa 1425061 ggtgaattcg cggaactgaa cggttgggaa gcggaaagtg aagctgcgat cctgttaaaa 1425121 ggccttggta tctcagaaga tctgcacaca aaaaagatgg cagacctcgg cggttcggag 1425181 aaggtaaaag ttctcttggc acaggcatta ttcggcaagc cggatgttct gctgctcgat 1425241 gagccgacga accacctgga ccttcaggca attcagtggc ttgaagagtt tctgattaac 1425301 tttgaaaaca cagttattgt cgtatcccat gaccgtcact ttttaaataa agtatgtacg 1425361 cacattgccg accttgattt taacaaaatt caaatctatg tcggaaacta tgatttctgg 1425421 tacgagtcaa gccagctggc gttaaagctt tctcaagaag cgaacaagaa aaaagaagag 1425481 cagattaaac agcttcaaga gtttgtcgct agattcagcg ccaatgcgtc taaatctaag 1425541 caggctacat caagaaagaa acttctcgaa aaaatcacgc tggatgatat taaaccgtct 1425601 tcccgccgct atccttatgt taacttcacg ccggaacggg aaatcggaaa tgatgttctt 1425661 cgcgtggaag gcttaacaaa aacaatcgat ggcgtaaagg tgcttgacaa tgtcagcttt 1425721 attatgaatc gagaagataa aattgctttc actggccgaa atgaacttgc tgttactacg 1425781 ctgtttaaaa tcatttccgg ggaaatggaa gctgacagcg gaacgtttaa atggggtgtt 1425841 accacatctc aagcgtattt tccaaaagac aacagcgaat atttcgaagg cagtgatctg 1425901 aaccttgtag actggcttcg ccaatattct ccgcacgacc aaagtgagag ctttttacgc 1425961 ggtttcttag gacgcatgct gttctctgga gaagaagtcc acaaaaaagc aaatgtactt 1426021 tccgggggag aaaaggtccg ctgtatgctg tcgaaagcga tgctttctgg cgccaatatt 1426081 ttaattttgg atgagccgac caaccattta gacctagagt ccattacagc gctcaataac 1426141 ggcttaatca gctttaaagg cgctatgctg tttacttccc atgaccatca gtttgtgcag 1426201 accattgcca acagaattat agaaattaca cctaacggca tcgtcgataa gcaaatgagc 1426261 tatgacgagt tccttgaaaa tgctgatgtg cagaaaaaat tgactgaact atacgccgaa 1426321 taaaaaagca gagatttctc tgcttttttt gatacctaaa tgtgaaagga gatcacaaca 1426381 tgaaattttt ggttgtcgga gcaggtggag taggcgggta tattggcgga cggctttcgg 1426441 agaaaggaaa tgatgtgaca tttctcgtgc gccaaaaacg agctgagcag cttaaaaaaa 1426501 ccgggcttgt catccatagt gaaaaaggga atgtatcatt tcagcccgaa ctaatcagtg 1426561 ccggagaaac agggcaattt gatgtcgtta tcattgcttc taaagcatac tcgcttggtc 1426621 aagtgataga ggatgtcaaa ccatttatcc atcaagaatc tgtcattatc ccttttttaa 1426681 atgggtaccg ccactatgag cagctatttg cggcattttc aaaagaacag gtgctgggcg 1426741 gcctgtgttt tatagaaagt gctttagaca acaaaggaga aattcatcat acgagcgcat 1426801 cgcatcgttt tgtatttgga gaatggaacg gcgagcgtac ggagcggata agagcgcttg 1426861 aagaggcatt ttcaggtgtg aaggctgaag tcatcattag cgggcatatc gagaaggaca 1426921 tttggaaaaa gtatctcttt attgcagcgc aagcggggat cacaacgtta tttcaacgac 1426981 cgcttggccc aatcctcgcc acagaagccg gacgtcacac ggcccaaact cttattgggg 1427041 aaatttgcac tgttttacga aaagaaggtg ttccggctga tccggctctt gaggaagaga 1427101 gctttcgtac gatgaccagc atgtcttacc atatgaagtc ctccatgctt cgggatatgg 1427161 aaaacggcca aacgacagaa ggcgaccacc tgcatggatt tttgattgaa aaagcaaaac 1427221 gtttatctct cgctgcacca gtattagaaa ccgtttatgc gaatctgcaa atgtatgaag 1427281 cagaaaaata aaaaaaggag gcggaaaagc ctccttttat ttacttaaaa agcccaattt 1427341 ccgtttctga agataggctc tcttttcccg tctgccgtaa ttccgtcaat attcatatcc 1427401 ttagaaccga tcataaagtc cacgtgtgta atgctttcat ttaggccttc tttgacaagc 1427461 tcttcacgag acatctgctt tccgccttca atattaaagg cataggcgct tccgatcgcc 1427521 aaatgatttg acgcgttttc atcaaacagc gtgttataga aaagaatgtt tgattgtgat 1427581 ataggcgaat cgtaaggaac aagtgccact tcacctaaat agtgagaacc ttcatctgtt 1427641 tccaccagtt cttttaaaat atcctcacct ttttcagctt taatgtcgac tatacggcca 1427701 ttttcaaacg tcagggtgaa attttcaata atatttccgc cgtagcttaa tggttttgtg 1427761 cttgatacca ctccgtcaac cccgtctttt tgcggcagcg tgaacacttc ttctgtcggc 1427821 atattggcca taaactcatg gccactttca ttcacgcttc ccgcacctgc ccaaacatgc 1427881 ttcctaggca gcttaattgt tagatcagtt ccttctgctt gataatgtaa ggcagcgtaa 1427941 tgtctctcgt tcaaatggtc aactttttca tgaagatttt ggtcatgatt gatccacgcc 1428001 tgaaccgggt tgtcttcatt tacgcgcgtc gctttaaaaa tttcttccca cagaaggtgg 1428061 atcgcttcct cctctgattt gccaggaaac accttgtgag cccagcctgc tgatgccgca 1428121 cctacgacag tccagctgac tttgtctgat tgaatatatt gtctgtatgt atgtaatgct 1428181 ttgcctgctg ctttttggaa tgccgcaatc cgtttggaat ctataccttt tagcaagtct 1428241 gggttcgacg acacaacaga aatgaaagca gctccatttt tggcaagctc ttctctgcct 1428301 tttgcttccc attcaggata ttcttcaaat gcttcaaacg gcgcaagttc gtattttaat 1428361 ttggcgactt cgtcatcctg ccaattcacg gtgacgtttt ttgcgccctt ttcatatgcg 1428421 tgttttacaa ttaaacggac aaaatcccga acgtctgttg aagcatttac gactacatac 1428481 tggccttttt ggacattaac gccgacttct accgccagct gtgcatatgt atttaatttc 1428541 tgtgaaaatg aatccatgaa tcattcctcc aagctttttt ctcatcatat caaatatgat 1428601 cctataaagg aaagaaggag cccaaagtga aaaacccaaa acgacacgtc ttgggttttt 1428661 tcaatattat ggatgattca gttttacagt gccgcctgca ggcgaatggg gcatatttgc 1428721 caaagaaatg ctcatgcctc caagaataat tccgcttaaa atggctgcga tcgctactct 1428781 tcttcctaaa tctcttagca tctgtttcct ccttaacgtt tctccatttc ccacaatatg 1428841 aaggaagtga ggaaaaaaga agcaagaaat ttgccgcgtg tgagaatttt gcgggtaaag 1428901 actatttaat tgccttttgc agcttatcaa tcacttctaa agaacggcct gtgccgattg 1428961 ctacagattc aagcgggttt tgcgccacgt gtacaggcac gacaatctct tctgtgagcc 1429021 attctttaat tccattaagg agcgcgccgc cgcctgttaa aataacgccg cgatcaacaa 1429081 tatctccgct caattcaggc ggacagtcct caagtgtcgc tctgatggct tcaagaatat 1429141 gcaggaggga ttcacgcatt gcatcttgaa tttcgttgga ttgaagcata atggtttttg 1429201 gaagacctgt cacgaggtca cgtccccgaa tttccattgc ctctggtata tgttcaatca 1429261 gagcatggcc aatttccatt tttacctgct cagctgtgcg ttcgccgatc agcaaattgt 1429321 attttttacg gacgaaagaa acgatatcct catcaagctg gtctccgccg atcctgatag 1429381 aatggcagga aacaacgcca ccgaaggaaa taatagcgac ctctgtcgtc cctccgccga 1429441 tatctactac cacattggca accggctcat caaccggtaa atccgctccg atggcggctg 1429501 caactggctc ttcgattaaa tgaacgtttt tcgcgccgca atttttcacc gcatcactga 1429561 tggcgcggcg ttctactgct gttgagcctg atggtgtgca aacgactacg ttcggttttc 1429621 tgaacgacat gccgatgctt tttgcggctt ttttcataat gtgctttagc aggtcagttg 1429681 tcatatcata gtctgcgatc acgccatctt tcatcggtct gacagcgaca atttttcccg 1429741 gtgttttacc gatcatgttt ttcgcgtcag ctccgattgc aagcactgct tttgtcgtcg 1429801 tatccactgc gacaacagat ggttcattta ggataatccc tttatttttg ctgtaaacaa 1429861 gtatattagc tgttcctaag tcaatcccga tttcagttga ttgaaacatg ttttcaccca 1429921 atctctatcc taatttaata tgattctaca tttaaagttt ctcagaaata ctgcgatttt 1429981 tgggggtgtg cgtcggtaaa gaaatgtttt tgtaaaaaat caaggaactg tgtaacagaa 1430041 gtaatacatt tttcggtttt atggaaaaaa tatcttgtaa ttcttataga aagcgggaaa 1430101 ctttttcaaa gtttcattcg tctacgatat attgaggtac atccttaaaa cattacatga 1430161 gaaaagaaac atttaaagga agaagggttt ttatgaaatc aataggtgtt gtgagaaaag 1430221 tagatgaatt aggccgcatt gtcatgccga ttgagttgag acgggcattg gatattgcca 1430281 taaaagacag cattgagttt tttgttgacg gagataaaat tatcttgaaa aagtacaaac 1430341 ctcatggcgt ttgtttaatg actggagaaa tcacttcaga aaataaagaa tacggcaacg 1430401 gtaaaattac gctaagccct gagggtgcac agctgcttct cgaagaaatt caagccgctt 1430461 taaaagaata aaattatgct aaaaaaggcg gagtgatatc atctccgcct tttttgcgtg 1430521 ccaatttttg attaccgccg cctaagataa gacatcaaga tatttggtaa tgaatgattt 1430581 gggatacttt acatatttta ctcaattatt tgtcgaagaa tggtacaata agtagagaaa 1430641 cacaagcggc aggtggtcat atgagaaaat atcaagctcg tatcatttcc atcattttgg 1430701 caatgatttt tataatgttt tgggattatt tattttattt tataggcaaa aacccgatta 1430761 attggcctgt tgatattgtg tatactgcag tcacgctggt aagtgtctgg atgttggctt 1430821 attatattga tgagaaacag cagctggtta agaaaatgaa ggataacgaa tggaagtata 1430881 aacagctttc tgaagaaaaa aaccgcatca tggataattt gcaggaaatc gtatttcaaa 1430941 cgaatgcaaa aggtgaaatt acatatttaa accaagcgtg ggcatctata accgggtttt 1431001 caatcagtga atgtatggga acaatgtata acgattactt cataaaagaa aagcacgtag 1431061 ccgaccacat taacacccaa atccaaaaca aagcgtcttc tggcatgttt acggcaaaat 1431121 acgtgacaaa aaacggcacg attttttggg gagaagttca ttataaactt tactatgacc 1431181 gggatgacca atttacaggc agcctgggta caatgtcaga tatcactgag cggaaagagg 1431241 ctgaagatga gctcattgag attaatgaac ggctggcgag ggaatcccag aaactatcaa 1431301 tcacaagtga acttgccgca ggtattgctc atgaggtcag aaacccttta acatctgtca 1431361 gcggtttcct ccagattatg aaaacacaat atccggacag aaaagactat tttgacatca 1431421 tcttttcaga gattaaaaga atcgatttag tgctcagcga gctgctgctg cttgcaaaac 1431481 cgcaggcaat cacatttaaa acacaccagc ttaatgagat cttgaaacaa gtcacgacat 1431541 tgcttgatac caatgcaatt ctgtccaata tcgtcataga gaaaaatttc aaagagacag 1431601 atggctgtat gattaatgga gacgaaaatc agctgaagca ggtctttatc aacatcatta 1431661 aaaacggaat tgaggcaatg ccaaagggcg gtgtcgtaac catttcaact gctaaaaccg 1431721 cctctcatgc agtgataagc gtaaaggatg aaggaaacgg catgccgcag gaaaagctga 1431781 agcagattgg caaacctttt tattcaacaa aagaaaaggg cactggactg ggacttccca 1431841 tttgtttgag aatcctgaag gaacatgacg gggaattgaa aatcgaaagt gaagctggaa 1431901 aaggcagcgt ctttcaagtg gttttgcctt taaaatcaga cagctgagag gagaaaaata 1431961 aagtgaactc gcttctgttt gtatacggga cattaagaaa gcatgaaaaa aaccatcatt 1432021 tgctggcaca atcggcatgt atcaatgagc aggcgagaac aaagggaagt ttgtttgctg 1432081 caaaagaggg gcccacagtt gttttcaatg atgaagatga aggctatata tatggcgaag 1432141 tatatgaagc agatgaattg tgtatacata agctcgatca attttttcaa ggatatcata 1432201 aacaaacggt gtttgtagaa acggatgtcg ggattaaaat tgcgcttatt tattttatga 1432261 acaaagacgg gtgtgccggt tttacgaaaa taagcagcgg cgactggaaa gaacatcaga 1432321 tgatcagcaa atcgaaaaat cccatttatt attttgccta tggatcatgc atggataatg 1432381 cccgctttca aaaagcggga gtcgatcact attttcaaga tccagtagga agagctgttt 1432441 taaaaggata cacaacccgc ttcacgctaa aaagggaaga cggttcaaga gcggacatgt 1432501 tggaagacgg aggaacaaca gaaggcgttt tataccgtat cccttattct gctctctcct 1432561 atctatataa aagggagggc gtcgaatctc ttacgtatcg gccggcattt gtagacgttg 1432621 aagctggcgg aaggcactac aaagactgtt taacctttct cgtcctccaa aaagaagcgg 1432681 aaattgcccc gcctcagcac tatcagattg aaatcgaacg cggagcggag ctgtatttgt 1432741 cgcctgagtt tactgaaaag ctcaagcggc atatgaattc gctgccaaaa ggataacact 1432801 gtaacaaaag aatatgataa aatttgatca atatcatgtc atataaagga gcaccacgat 1432861 gaaaaaagaa tttgcggtaa ttgggctggg ccgttttggt ggcagtattt gcaaagcatt 1432921 aagcgaagaa ggcgtcgagg ttatggcaat ggatatcgat gaagataaag tcaacgagta 1432981 tgccaagatt gcatctcacg cagttatcgg tgattcgaca gacgaatctg tcctgaaaaa 1433041 tttaggcctg cgaaattttg accacgttat tgtagcaatc ggggaaaata ttcaagcgag 1433101 tattttaacg acactcattc tgaaagaact tggcgtccat acgattacag ttaaagcgca 1433161 gaacgattat cacgaaaaag tgctgtctaa aattggtgcg gatcacatcg tccacccgga 1433221 acgcgatatg gcaaaacgaa ttgcgcataa tatcgtgtcc aacaatgtac ttgactattt 1433281 ggagctgtct gaagagcata gtcttgttga aatcgtagct aacagccgcc tggctggaaa 1433341 tacgcttctc gatttagata ttcgcgcaaa atacggtatt aacatcgtag ccataaaaag 1433401 gggcaaggaa gtcatcgtat caccgcttgc aaccgaagtc atccaccaag aagatatact 1433461 cattgttatt ggatcagtta cagacatctc ccgtttcgaa aaaagagttc ttcatacaaa 1433521 atagcagcca aataagccgt cctcaaaggg cggtttttca tattatcaga atataacaac 1433581 tttaatgaac tgagcgtcaa tttcttaaaa tttcattgac taagcacagg cgttccgata 1433641 gcatattgta ccatataata aaaaaaggag gggcctattt gaataaagaa gcgctagtca 1433701 ataggctgaa tgcttcagcc aaaagacaaa aagctgatat cgtcattaaa aacggaaaaa 1433761 tcatggacgt atataatcaa gaatggatat atgaagatat tgcgattaca gatggagtta 1433821 ttgtaggcct cggtgagtat gaaggcgaaa atatcattga tgcagaggga caaatgattg 1433881 ttccgggttt tattgatgga catgtacata ttgagtcgtc aatggttaca ccgattgagt 1433941 tcgctaaagc agtgttgcct catggcgtga cgacggttgt tacagatccg catgagatcg 1434001 cgaatgtgtc tggtgaaaaa gggattgagt ttatgcttga acaagctcgg catacaccgc 1434061 tgaatatcca ttttatgctt ccttccagtg tgcctgccgc aagttttgag cgatcaggcg 1434121 caattctcaa agctgccgat ctcaagcctt tttatgaaga agaagaagta ttagggctgg 1434181 ctgaagttat ggattatgtg tcggttcagc aggctgaaaa agacatggtt cagaaactgc 1434241 ttgatgcccg tgtggcagga aaaaggatag acggtcattt agctggttta tcaacagacc 1434301 tcattaacat ttacagaacc gcatttgtct taaacgacca tgaagtaaca tcgaaggaag 1434361 aagcccttga tcgtatcaga aggggcatgt atgtcatgat gcgtgaagga tcagtcgcca 1434421 aaaacacgct caatgtgctg ccggcggtga atgaaaagaa cgcacgccgg ttctttttct 1434481 gtacggatga taagcatgtg gatgatttat tgtcagaggg aagtgtaaac catcaggtga 1434541 aaatggcgat tcaagccgga cttaatccgt ttttagccta tcagctagga agcctcaatg 1434601 cagccgaatg ctacggatta gatacaaagg gagcgattgc cccgggtttt gacgctgatt 1434661 tgctttttgt atctgatctg gaaaatgtca ctgtcacaat gacgatggta aaagggcaga 1434721 ctgttgctga agacagcaaa gcggtctatc aggatcatgc ttcaactgca gcaccagatc 1434781 aggcactgct tgattctgtt aagcttgctg ctcctcttaa caaacaggat tttcatatgc 1434841 caatcgattc agagcagcag atcaatgtca ttcaaatcat accaaatcag cttgaaacac 1434901 gattagtaca agttccggct cctgttgccc gcgaatttga gcctgacact gagcttgatt 1434961 tgttaaagat tgcagttgtc gagcggcata aaggattaaa agaaaccgga cttggtgttg 1435021 tgaaaggttt tggattcaag agcggagcga ttgccacaac catttcacac gactcccata 1435081 atattattgc cgtcggaacg aatgatgagg atatcgcggc ggcagttaat aagctgcagg 1435141 aaattggcgg aggattaaca attataaaaa atggggaaga gctccattca gtaccgctgc 1435201 cgattgcagg gttattatcc gaccaatctg cagagcaagt gaatcaaagc ttgctgacgc 1435261 ttcatgataa attgtcgtta atcggtttca caggcggatt taatccattt ttgacattgt 1435321 cgtttttagc gttgcctgtc attcctgata ttaaaatgac gactacggga ttattcgatg 1435381 taaaatcatt tcaacacata tcactgcaat aaaaagaggc actcccttag ggagtgcctc 1435441 tttttttaaa cctccataat gatcggcagg atcattggac ggcgctttgt tttttcgtac 1435501 aagaaaggtg caagcgtgtc tgtaatttcg tttttgattt cagaccattg agtcgttttt 1435561 cgttccatta ctttttgtaa gtgatttgaa atgagctctt gagcgtcgtt gatcaagtca 1435621 ccagattctc tcatgtacac aaatcctctg gaaatcaaat caggacccgc tgaaatcttg 1435681 aagtcgtcca tgtcaatgct gacaacaacg atgacaagtc cttcttcaga gagaattctg 1435741 cgatcacgaa gtacgatatt gccaatatca ccgataccgc ttccgtcaat gtacactgaa 1435801 ccggacggga tttttcctgc aactgaagcc tcatcgcctt taagtgctaa tacttcacca 1435861 ttatccatga taaagcagtt ttcctctggg atgccacaat ctgttgcaag tttgacatgc 1435921 atcttttgca ttctgtactc accgtgaatc ggcatgaaga atttaggctt gattaaacga 1435981 agcatcagct tctgttcttc ctgtccgccg tgaccggatg tatggatatc gttaagaggg 1436041 ccgtgaataa cctcagcacc cgcacgatac agctggttga ttgttcgact cacgctgatt 1436101 gtgttgcctg ggatagggga tgaagaaaat acgactgtat ccccaggatt gattgaaatt 1436161 tggcggtgtg tgccgtttgc aattcttgat aacgccgcca ttggttcccc ttggcttcct 1436221 gtacataaaa ttgttacttt attagcaggc atacgattga tttcgttatg ctcaataaac 1436281 gtatttttag gacagttaat ataaccgagt gtctgtccaa tttcgatagc cgattccata 1436341 ctgcgtccaa atacggcaac ttttcttcca ttttgtacag cagcttcaat tacctgctgc 1436401 aagcggtgaa tattcgacgc aaatgtggcg aagataattc ggccgtccac cttgcggaaa 1436461 atgtcatgaa tgctttctcc tacacggcgc tcagacatgg taaactccgg attttcactg 1436521 tttgtgctgt ctgaaagaag gcacaaaacg ccttctttac cgatttcggc cattttcgtt 1436581 aagtttgccg gctcgccgac tggagtaaag tcgaatttga aatccccagt atgtacgatg 1436641 tttccgggcg gcgtttttac aacaatgccg taggaatccg gaatactgtg tgttgttctg 1436701 aagaatgaca cagccgtttt gcggaacttt acaatatcat cctcgccgat aatgttcagt 1436761 ttcgtctgtc tcaataatcc atgctcttca agtttattcc gaagtaagcc gatcgcgagt 1436821 tttccgccgt atacaggaat attcacttgt ctgagcaggt atggaatacc gccgatgtgg 1436881 tcttcgtgcc cgtgggtgat aaaaagccct ttaattttat cttcgttttt gactaaatac 1436941 gtataatcag ggatgacgta gtcaattccg agcagttcgt cctcgggaaa cttgatcccc 1437001 gcatcaatca gtacaatttc atcctggaat tgcaccgcgt acgtattttt accgatttcg 1437061 cccaaacctc cgagggcgaa aacagcagtc tgatcatttt ttacaaattt cataccgctc 1437121 ataactccaa tactttaaaa ttttcgctct gttgttcata ttctaagaat gcaccatcaa 1437181 caggtgtaat aaactcaata ttaaatttct tttctttcag ctttgttctg acgtcacgct 1437241 cagatacgcc ttcaatataa agtgaatctg tcttttcccg aacaggtact tcgtcagcct 1437301 tctcttgata aaatacctta taaatcattc caaatctctc cttaaatgcc gtatgttaga 1437361 ctcgctcatt ctattatatt cgaaaacgga atataaggaa agccttgagc aaaataagga 1437421 tctctcaaaa agtgaaagat cccttgtcag gcaattgctt tcttacggag cattccgttc 1437481 cattgtcttc tgagtttctt tcttaattta cgcagcatta gccagtccct cctttaatga 1437541 aaaatttgtc ccagagttct tttatacaaa tagtatacgg agattgagga agacttttcg 1437601 tggttattaa tggaatttaa tatgattttt gaacgaaatt gtttgctgaa tgacaatctt 1437661 tttgtatgat gagggtggga attgcagacc aagacgataa aggggaagtt gcgatggatt 1437721 ctaaattaat cttttttgat attgacggca caatatatga tcatgataag aatataccgg 1437781 aaagtacgag aaaaaccgtg gcggagcttc agcgccaagg gcatcatgtg tttattgcca 1437841 gcggccggtc tccatttttg gttaagccga ttttggagga gctgggcatc cactcattta 1437901 tttcctacaa tggacagttt gttgtctttg aaaatcaagt gatttataaa aatccgctgc 1437961 ctgaaaatgc aatcaggcga ttattaaagc aggcggatga aggcaagcat cctgttgtgt 1438021 ttatggctga ggacacgatg aaagcgactg ttgcggatca cccccatgtt ctcgagggaa 1438081 tcggcagcct taaaacagat tatccagaga ccgatgacct tttttatgaa ggaaaagaaa 1438141 tttttcagct tcttttattt tgtcaggatg aagaagaaaa agcttatgcc gcttttcctg 1438201 agtttgatct agttcgctgg catgagctat cgactgatgt tctgccgcac ggaggttcga 1438261 aggcagaagg aatcaaaaaa gtgattgagc gtcttccgtt tgatatcggc gatacatatg 1438321 ctttcggcga cggattaaat gatttgcaaa tgattgaata cgttgggaca ggcgttgcta 1438381 tgggaaatgc tgttcccgaa ctgaaagaaa tcgcggactt tgtaacaaaa ccggtggacg 1438441 aggatggaat tgcatacgct gtcaaagaat tgggcctttt aaaataaaga aacggctggc 1438501 attgtgccag ccgttttctc ttttagcgct caattgcgat tgcattttca ggttctttga 1438561 aaggattttc cttatcaata tgatcataga acataacgcc gttcaaatga tcgatctcat 1438621 gctgaaacac aatagccgga aatcctttta aacgaatatc aatattttcg ccttctagtg 1438681 ttgttccttt tactctgatg cgagcatagc ggggaacata accgggaatc gcttcatcca 1438741 cagagaggca gccctcgccg cttgttaagt agcttttttc aactgaatgg ctgacgatct 1438801 taggattaaa cagagcatag ctgtataatt taccggaagc atcttccgca tgaacggcga 1438861 tcattcgttt tttgatatta atttgaggag ctgcgagtcc tacgccaggg cgcagcttgt 1438921 atttttcggc taattctgga ttttggctgt ttttaacaaa ttcgatcatg tcggccagct 1438981 gctgtttttc tgcatcagtt ggaggcagct caacaggttc ggcagtctct ctgagggctg 1439041 gatggccgtc acgtacgatg ttttccatag taatcaagaa acttcactcc taaagcttaa 1439101 tatgtaaatt atatcggatt tcttcacaaa ggtgcaacga aacgaatgac cagccgtata 1439161 tggctggtca atttcatgct gtgtggttag caacagcctc cacctaaata agcagctccg 1439221 acaatgatta acagaatgaa taaaacaacg attagcgcaa aggtgcggcc gtagccatat 1439281 ccgcagccac catatccgta accaccataa ctgcagcagc ctccgccgta accatatcca 1439341 tacatattac ataacctcct cttttaatta cgccagagcc tttataagta ggcatagcgt 1439401 ctaatataac ctatgtaaaa acaaaaaagt tgtatggtca tctgtcctga tttttcactt 1439461 ttttgattta atttcagtat tgcatttata cagcacggct attgccaaat gtccccatgg 1439521 attctatagt agaaattgtc aagattgggg gatttaacgt gaaagacgct ataaaacggc 1439581 ggcctggaat caagatcgga gctttttgtg ccatggcact gatattaaca ggatgcatgg 1439641 gacaggaccc ggttgattca cttcatcatt cattagaaaa agccgcggaa tcggaaaagc 1439701 cgtttcaaga agaacaaaac acactcaaag aattagaggc caaagaaaat cagctttacg 1439761 atagtgttat gaagctcaat atggatgatt ataaaaaaat tgttgcttta tctaataagg 1439821 cgcttgaaaa tgtcagcaag cgcgaagaac acctaaagct tgaaaatgac agcatgaaaa 1439881 aatcggaaac agaatttgag gaagcaaaaa cgtcagcgga acatattaag gaaaaagaca 1439941 taaaagaaaa ggccgatgcc gcagcaaacc atatggagaa aagatataca tcatatggca 1440001 ctatgtataa agagtataaa aaagcgcttg agcttaataa aaaactgtat atgcagctga 1440061 aagacaaaga tttgacaaga gatgatctgg atcagcagat cgataaagtc aatgcttctt 1440121 atgaaaagat ccttaaatat agcggagaat ttaatgaaca aaccgaaaaa tataataaag 1440181 cccgggaaga tttatatgat gctgcaggct atcgtgtgaa aaagagctga ctcgatcagc 1440241 tctttttttg aatgaaatgc gattcggatt tcgttcaaaa ttttcatttc tattgtagta 1440301 cagcatagta aggtatacta gtacagtttt gggtgcggtt ggcatctgtt tttttgatga 1440361 aaatgtaaag cgaatacatt tattgaaaat cagcgatgaa aacgattgac ggttcttctt 1440421 tatttggtgt aaactaatcc atgttaagcg gtgttgtatt agttttttac aacttcgaaa 1440481 taatacagtt caaagcagag tgtaactatc ctacataaaa ggttttggca aactggggat 1440541 cggctaaaat ataatacgac ttactgctga tactttaggg taccctaagt ttgtatgtat 1440601 aaaaggaatg cacgtctaat gactgtttaa aagaaaggaa gaggtgactt agtatggctg 1440661 caaaaacgaa aaaagctatc gttgacagta agaagcaatt tgatgccatt aaaaagcagt 1440721 tcgaaacgtt ccaaatttta aatgaaaagg gagaagtcgt gaatgaagcg gcgatgcctg 1440781 atttaactga tgatcaatta aaagagctaa tgcgccgcat ggtatttacg cgtgtgcttg 1440841 accaacgctc tatctcatta aaccgtcaag gacgtctcgg attttacgct cctactgcgg 1440901 gtcaagaagc ttctcagatt gcaacgcatt tcgcgcttga aaaagaagac tttgttcttc 1440961 ctggataccg tgatgtgcct cagttaattt ggcacggcct tccattatat caagcgtttc 1441021 ttttctctcg cggacatttc agaggaaacc aaatgcctga tgatgtgaat gccctttctc 1441081 cacaaatcat tatcggtgct caatacattc aaactgccgg tgttgcgcta ggtcttaaaa 1441141 aacgcggtaa gaaagctgtc gcaatcactt acactggtga cggcggagct tctcaagggg 1441201 acttctacga aggaattaac tttgccggag cttataaagc acctgcaatc ttcgtggtgc 1441261 aaaacaaccg ttacgcgatt tcaactcctg ttgaaaaaca atctgcagct gaaacaattg 1441321 cacaaaaagc tgtagctgcc ggtattgtcg gcgtacaagt agacggaatg gatccgcttg 1441381 ctgtatacgc agcaactgct gaagcacgcg agcgcgcaat caacggcgaa ggtccaacac 1441441 taattgaaac acttacattc cgttatggcc cgcacacaat ggctggtgac gatcctacta 1441501 aatatcgtac aaaagaaatc gaaaatgagt gggaacaaaa agatccgctt gtacgtttcc 1441561 gtgcgttcct tgaaaacaaa ggcttatggt ctgaagaaga agaagcaaaa gtgattgagg 1441621 atgcgaaaga agaaattaag caagcgatca aaaaagctga tgctgaaccg aagcaaaaag 1441681 taactgattt aatgaaaatc atgtacgaaa aaatgcctca caaccttgag gagcaatttg 1441741 aaatttatac acagaaggag tcgaagtaag ccatggcgca aatgacaatg attcaagcaa 1441801 tcacggatgc gttacgcaca gaactgaaaa atgacgaaaa tgtcttagtt ttcggagaag 1441861 acgttggtgt aaacggcggc gtattccgtg cgacagaagg attgcaaaaa gaattcggtg 1441921 aagaccgtgt gtttgacacg ccacttgctg aatctggtat cggcggtctt gcccttggtt 1441981 taggcttaaa cggcttccgt ccggtaatgg aaatccaatt cttcggattt gtttatgaag 1442041 taatggattc agtttctggc caaatggctc gtatgcgcta ccgttctggc ggacgctgga 1442101 cttcacctgt aacaattcgt tctccattcg gcggcggtgt tcatactcct gaacttcacg 1442161 ctgacagctt ggaaggtctt gttgcacaac agcctggtat caaagttgtt attccatcaa 1442221 ctccttacga tgccaaagga cttttaattt ctgcgatcag agacaatgat cctgttgtct 1442281 tcttagagca tatgaagctt taccgttctt tccgtcagga agttcctgaa gaagaataca 1442341 caattgagct tggaaaagct gacgtgaaac gtgaaggtac tgatctttca atcatcactt 1442401 acggcgcaat ggttcatgaa tcattaaaag ctgctgatga gcttgaaaaa gacggcattt 1442461 ctgctgaagt tgtcgacctt cgtacagtaa gcccacttga tatcgataca attatcgcct 1442521 ctgtagaaaa aacaggacgc gcgattgtcg ttcaagaggc acaaaaacaa gccggtattg 1442581 ctgcaaacgt agtagcagaa attaatgacc gtgcgatcct gagcttggaa gcacctgtac 1442641 ttcgcgttgc agcgccagat acagtatttc ctttctctca agcggagagc gtatggcttc 1442701 caaaccataa agacgttctt gaaacagcaa gaaaagtgct tgaattttaa tcaaactgca 1442761 taatcgagag ggaagatgaa cgttttccct ctattatata tctgttttca atgcttacga 1442821 tgtaaacttt aaaattgctt aatcaaacta ggaggtcgag aactgtggca tttgaattta 1442881 aacttccaga tatcggggaa ggtatccacg aaggcgaaat cgtaaaatgg tttgtcaagc 1442941 ctaacgacga ggtagacgaa gatgatgtac tggctgaagt ccaaaatgat aaagcagtag 1443001 tagaaattcc ttcacctgtt aaaggaaaag tattagaatt aaaagttgaa gagggaacgg 1443061 ttgcaactgt tggacaaacg attattacgt ttgatgcacc tggttacgaa gatcttcaat 1443121 ttaaaggcag cgacgagtct gacgatgcga aaactgaagc acaagttcag tcaactgcag 1443181 aagctggaca agacgttgcg aaagaagagc aagctcaaga gcctgcaaaa gctactggcg 1443241 caggacagca ggatcaagct gaagttgacc cgaacaaacg cgtgatcgct atgccttccg 1443301 tacgtaaata tgcacgtgaa aaaggtgtag acatccgtaa ggttactggt tcaggcaaca 1443361 acggacgtgt tgtaaaagaa gatatcgaca gctttgtaaa cggaggagcg caagaagctg 1443421 caccgcaaga aacagctgca ccacaagaaa cagctgctaa accggctgct gcaccagctc 1443481 cagagggcga attcccagaa acacgcgaaa aaatgagcgg tatccgtaaa gcaattgcaa 1443541 aagcgatggt taactctaaa cacactgctc ctcacgtaac gttaatggac gaagtggacg 1443601 taacaaacct tgttgcacat cgtaaacagt tcaaacaggt tgctgctgat caaggaatca 1443661 agctgactta cttgccttac gttgtaaaag ctcttacatc tgcactgaaa aaattccctg 1443721 ttttaaacac gtcaattgac gataaaacag atgaagtcat ccaaaaacat tacttcaaca 1443781 tcggtatcgc tgctgacact gaaaaaggct tgcttgtacc ggttgtgaaa aatgcagatc 1443841 gtaaatctgt ctttgaaatt tctgatgaaa tcaatggcct tgcaacaaaa gctcgtgaag 1443901 gcaagcttgc tccagctgaa atgaaaggcg catcttgcac aattacaaac atcggttctg 1443961 ccggcggaca atggttcact ccggttatca accatccaga agttgcgatt cttggtatcg 1444021 gacgcattgc agaaaaagcg attgttcgtg atggcgaaat cgtagcagct ccagtcttag 1444081 ctctttctct cagcttcgac caccgtatga tcgacggagc aactgcgcaa aatgcattaa 1444141 atcacatcaa gcgtttactg aacgatccac aattaatttt aatggaggcg taatgttatg 1444201 gtagtaggag atttccctat tgaaacagat actcttgtaa ttggtgcggg acctggcggc 1444261 tatgtagctg ccatccgcgc tgcacagctt ggacaaaaag taacagtcgt tgaaaaagca 1444321 actcttggag gcgtttgtct gaacgttgga tgtatccctt caaaagcgct gatcaatgca 1444381 ggtcaccgtt atgagaatgc aaaacattct gatgacatgg gaatcactgc tgagaatgta 1444441 acagttgatt tcacaaaagt tcaagaatgg aaagcttctg ttgtcaacaa gcttactggc 1444501 ggtgtagcag gtcttcttaa aggcaacaaa gtagatgttg taaaaggtga agcttacttt 1444561 gtagacagca attcagttcg tgttatggat gagaactctg ctcaaacata cacgtttaaa 1444621 aacgcaatca ttgctactgg ttctcgtcct atcgaattgc caaacttcaa atatagtgag 1444681 cgtgtcctga attcaactgg cgctttggct cttaaagaaa ttcctaaaaa gctcgttgtt 1444741 atcggcggcg gatacatcgg aactgaactt ggaactgcgt atgctaactt cggtactgaa 1444801 cttgttattc ttgaaggcgg agatgaaatt cttcctggct tcgaaaaaca aatgagttct 1444861 ctcgttacac gcagactgaa gaaaaaaggc aacgttgaaa tccatacaaa cgcgatggct 1444921 aaaggcgttg aagaaagacc agacggcgta acagttactt tcgaagtaaa aggcgaagaa 1444981 aaaactgttg atgctgatta cgtattgatt acagtaggac gccgtccaaa cactgatgag 1445041 cttggtcttg agcaagtcgg tatcgaaatg acggaccgcg gtatcgtgaa aactgacaaa 1445101 cagtgccgca caaacgtacc taacatttat gcaatcggtg atatcatcga aggaccgccg 1445161 cttgctcata aagcatctta cgaaggtaaa atcgctgcag aagctatcgc tggagagcct 1445221 gcagaaatcg attaccttgg tattcctgcg gttgttttct ctgagcctga acttgcatca 1445281 gttggttaca ctgaagcaca ggcgaaagaa gaaggtcttg acattgttgc tgctaaattc 1445341 ccatttgcag caaacggccg cgcgctttct cttaacgaaa cagacggctt catgaagctg 1445401 atcactcgta aagaggacgg tcttgtgatc ggtgcgcaaa tcgccggagc aagtgcttct 1445461 gatatgattt ctgaattaag cttagcgatt gaaggcggca tgactgctga agatatcgca 1445521 atgacaattc acgctcaccc aacattgggc gaaatcacaa tggaagctgc tgaagtggca 1445581 atcggaagtc cgattcacat cgtaaaataa ttttcatatc aaaaacagcc ccgctttgag 1445641 cgagggctgt ttttttattt tgacagcaca tgctgtaatg gtttaatgat gtcttctttc 1445701 tttttcacac atccctcgat tttcaccacg acatggcgct gatcaacaac cataagggta 1445761 gggacagttt caatctcatc ttcccagcct tcttttttat catagacctt cattttatct 1445821 atttgctcgg gataatcttt ttctaaatca agcagtgcat cgtaataagg cgcttcctgg 1445881 tctatttggt tctcatcaga aaaaaacagg atttgtgtat gatgaatgtt gtcaatccgg 1445941 ctttttttca tcggattgat ggtggaaagc gtacagcccg ataaagcaaa tactattatc 1446001 agcatgggga ataccgcgcg atatcgcatc tatcttctcc tctgtataaa cagtagttaa 1446061 ctagctttag tttatcacga gagacggctt aatctgcttc ttgttaccta attgttatat 1446121 aattgaaacc gtttttaaag tgagattaca tattatatca atcgtttaaa atagcaacct 1446181 ggggtatatt gaattttttg ctgcattctt ggatgaaagt tcaagaaaac gtgcaattac 1446241 attatgtgct gtggcatata tatcgagtaa agcttctgta tgaagaagat attgtatgat 1446301 ggaaaatgga aaaacaaggt gaatatgatg atatgaaata aaatgtgtta tacagtttgt 1446361 tgttgacatt ttaaatgtga catattaata taataacaac aaaagaaatt aagcgttttc 1446421 aaatttcaaa gaaatgggga ataagagatg ggtacgattg tttgccaaga ttgcaacgaa 1446481 gccattcatt actttgaaga tgagaaagtg acaacattat atggaacttg ctgcggacaa 1446541 tgtcaatgtc ctgttgatga agagtaaaaa aaagcatgcg gcttaaagcc gcatgctttt 1446601 tattttttat tgaattgctt tttgttcttt gatgacccgg atcatatgta aagtcgagtc 1446661 ctcaggtcct tgaacaggga ggcctgcgtc aaggttttta aaaatgtagc tgatgttttc 1446721 ttctgtaata atttctcctg ggatgaagat tggaatacca ggcggatata ccatgacaaa 1446781 ttcagcaata atccgtccgg atgcttcttt taatgggatg acttccgtat ttgcatagaa 1446841 agcatcacgc ggagtcattg ccaataaagg tatttctgga agcagaacct cagtttgctg 1446901 atgtgttaca tcttgttctg acatttgctg tgcgatctca gttaaagcct ctacaagccg 1446961 gtctgcatca ttttggctgt caccaggagt gaaaatacac aaaatattgt acagatcaga 1447021 aagctccacc tcaatattaa aggattcacg aagccatttt tccacgtcat gtcctgtcag 1447081 gccaagactt ttcacagaga taatcaattt tgtcggatca tagctgtaag ctgctttcga 1447141 cccaagaatc tcagaaccga cacaataaat gccttcaatc tgattgaggc gatctctcgt 1447201 ctgattggca agcttgagtg tttcctcagc aagctggcgg ccttctgttg caaggcgttt 1447261 tctggcaaca tccaaagaag cgagaagcaa gtaagaagtt gacgtagttg tcagcatgct 1447321 caggatggat tgcactctgt ctttagatac aaggccttct ctcatgttta aaatagagct 1447381 ttgtgtcagt gatccgccca gcttgtgtac acttgtcgct gctatgtccg ctcctgcctg 1447441 catagccgat agcggcaatt cgtcgtgaaa atgaatgtga acgccgtgtg cttcatccac 1447501 aagcactggc acatcaaacg aatgagcgag ttctacgatg ctttttaagt cggctgcaac 1447561 accgaaatat gtcgggttga tgacgagaag cccttttgca tccggatgct cggtaagcgc 1447621 ccgtttagca gattcaagtg taattccgtg ggagatgccc aattcattgt caatttcagg 1447681 atgaataaaa attggaaccg ctccggaaaa tacaatagct gtcataattg atttatgaac 1447741 atttcttgga ataataattt tatcaccagg tccgcaaaca gccattacca ttgtcataat 1447801 ggcgccgctt gttccttgaa cagaaaaaaa tgtatgatcc gctccaaatg cttcagcagc 1447861 cagatcttgt gcttgtttaa taatgccttt tggcgcgtgc agatcgtcta atggttcaat 1447921 attaatcaaa tctatgctta acgcgttttc accgataaat tgtctgaatt ctgggtccat 1447981 tcctgcccct tttttatggc cgggaatgtg gaattgaaca ggctgtctgc ttgcatgctt 1448041 tttcagtcct gtgtataagg gtgtttcatg ttgcgacaat tgttttccca cctttgtaat 1448101 catacctatg cataatagtg tgtattaaaa tcagtttctc aaccgttttt tagacgtaaa 1448161 acaaatgaat tatattatga acttgaaaga atgtaaagaa caatttatga tcaaatgaag 1448221 atgctttctc ttaagggaag taaatctaca aggagtgaag aaaatggagt atcaatatcc 1448281 gatgaatgaa gattggacaa ccgaagaagc agtggatgtg attgcatttt tccagcaggt 1448341 tgagcttgca tatgaaaaag gggcggatcg tgaagaactg cttaaagctt accgccgttt 1448401 caaggaaatt gtaccgggga aggccgaaga aaaaaagcta tgcggcgagt ttgaggaaca 1448461 aagtacatat tctccttatc gcacggtcaa acaggcgaga gaatctgatc acgcgaagat 1448521 taagatgtaa gaaaaagagc cgggggatat cccggctctt ttttatgctt gtgttacttt 1448581 ttgggtgaga cggtacagaa aagcaagctg tttaaaggca tcgtcgatac gctgaaggaa 1448641 ttcctggtta ttcatattca gcacttcttc tttttggagc tggatgccgc ataacagctc 1448701 ggctttcttt acagtctgca aacgctcaaa cagtgtcttc agctgttcct tgtccatttc 1448761 agactgttta tgtactcccg gttttgtgtg atctgcagac caaacgaagc tgtcagggat 1448821 atttttcgta atggtttctt ggttcacttc aagcaatttg ccgtattctt ctttgatagg 1448881 ggattcataa ataatcgcga accatacaaa gacgtggctt tcccataaac caatttggaa 1448941 atgcggcagt tttttatagc ctcttttgct gtttgcgaac gccacccagc tgtcagccgg 1449001 gggattgacg gatcttcttg cgtgctttgc cacatgcgga aacatttcat ctccggttaa 1449061 agctgataaa gttggggcaa aatgttcgcc tagagctgta agcttcggac ggaccgtctc 1449121 ttttaatact tccatgcgcg cgtctaagcc ttctattgta aatgtgttaa agtcttcttc 1449181 agtgaaacgc atttgtgtca tgattttcct ccttcatgct aagtatacat attttatcac 1449241 agttcatacg agcttcaaaa agattgagcg cgtttgaagt aaggagaaat gtggtaataa 1449301 acgagtaggt aaacacacaa ttttcagaat catgttgcgc gtaaatagaa caatcatacg 1449361 atataagaag taatcattgt tgaatggcaa aatgggatgc ttttttacaa acaaatgatc 1449421 tctggaaggg gcgaaagaca atgaggcaag ttgtaaaaga gggatttaag gaagagaaaa 1449481 acaatcgtgt tgctgtctgg agactagagg ttgattatga attggcaacc ctatatgaag 1449541 caatgcagaa agaaaatgaa gagcagattg aacaaagcaa aaacaaactt gagcgactta 1449601 gaaaagaatg gattcgtctt aacgggtaaa aaagcgatag tgaaaacgaa ccgcatgaat 1449661 ggttcgtttt tacgtgagaa gggatatttt tcattttcct tgctttttca ttgccgttat 1449721 cagtatccta taaaataaaa ggtctacata gaagagaggt acgaacgaat gacaaattgg 1449781 acggaaatcg atgagattgc aaagaaatgg ataagagaag caggcgcgag aattacacaa 1449841 tccatgcatg aaagcctgac aattgaaacg aaatcaaatc cgaatgattt agtcaccaat 1449901 attgacaaag aaaccgaaaa gtttttcatt gatcgaattc aagaaacatt tccgggacat 1449961 cggatactcg gtgaagaggg gcaaggagac aaaatccact cacttgaggg agtcgtatgg 1450021 attattgatc cgattgatgg gacgatgaat tttgtgcacc agcaaagaaa ttttgcgatt 1450081 tccattggga tttttgaaaa cggtgaaggt aaaatcggtt taatttatga tgtggtgcac 1450141 gatgagttgt atcacgcatt tagcggcaga ggagcttata tgaatgaaac gaagctggct 1450201 ccattaaaag aaaccgtcat tgaagaagcg attcttgcca ttaatgcaac atgggtaacg 1450261 gaaaacagaa gaattgatca aagtgtgtta gcgccacttg tgaaaagagt cagaggcaca 1450321 cgctcctacg gttctgccgc tttagagctg gcaaatgtcg cggcaggaag aatagatgct 1450381 tacatcacga tgcggcttgc gccatgggac tacgcagccg gctgtgtgct gttaaatgaa 1450441 gtaggaggca cctatacgac cattgaagga gagccgttta cctttttaga aaaccacagt 1450501 gtgctagccg gaaacccatc tatacataaa acgatatttg aagagtatct tcatgctcgg 1450561 aagtaggcca tttgagcagg atgatctcag cttgttagaa aagctcgcgg aggctcatcc 1450621 tgtatggaaa gaggaggagt ttggagataa agatgcagaa gactatatca tttcctactc 1450681 catgtacaac ggttcatggc ttgtatggga aaaagacggt atgcctgttg ccgtcagcta 1450741 ccatctcgag tggtctcctt caaacggtaa gccgtggctc ggaacggtcc tgattgaccc 1450801 ggctgaagaa aaaaagggac atgcgaagat gatcattgaa cagatcagca aattgcttag 1450861 agcgaaacat aaagcgatgt ttgcgggagt tcccattgag cgcagggaat ggatactgtt 1450921 tttaagccaa tgcggctttg aacagctgaa aacggaaaaa gatgagaaag gcaaatcatt 1450981 tatgatcttg gtgaagcctt tagcagaagc tgccgtatga taatggcagc ttatttgctg 1451041 catgcgggtt caataaaaag cctctcaaac attgagaggc ttctgatgat ttgaaaatta 1451101 tttttttacc gcatgaatat aatgaatcgt ttcaaacgct gacaaattgt cttttcgatt 1451161 actaaagaaa aggtcattga tgtcgtctgg tgatagatgt tcatagatca gtaaaccaga 1451221 tgactctaac agatgttcaa tctcttgata agtgaaacat gatttcatcg gttccccgct 1451281 tgcggcagcc atcttcacca tatgttcaac tcgattcgac gtcccttttg ctgtaaaaag 1451341 tgtttcgtcc gcataatcaa aaacaataga gcttccaggc gggacatgag aaaataaatt 1451401 gctgatcaag cttgcatttt cttcccgtgt tacataataa gacactccga gaaggctgaa 1451461 gaatgttttt gtgtttttaa atccttcatc taagagagga tcatacgaaa acgttttggt 1451521 gaaatccata ggaacaaaat gaagatgacc cggaattgtc agatttgcat ccttcagctt 1451581 attttttttc aattgctgtg tggccggatg atcaacctcg aaaacctgta agctgttttc 1451641 taattctgga tgccgaaagc agaaagtatc cagtcccgct ccaagaatga catactgttt 1451701 tgcccccagg attaattcgt tgtgcaagac tttttcacaa taagaagcac gtgctagggg 1451761 cgttggagac agctggattt gtgcaaccca ttttaatatt ttttcaggat cattttgaag 1451821 acgttcggcg atctctttgt tgaaaaacga tatttcttga atcatatttt tactgatgtc 1451881 gataaactct ttttcgttaa tgagatcttt tgcgataaaa tcatcaaaaa taagaggtgt 1451941 gtcatatcgg ctgtgatatg cacgggcaaa agctgaaatt agagacgtta agctggactc 1452001 atttttcctc atgaaatgat cctccacaaa aaataagatt cccctggcca ggagaatctt 1452061 attatacata caaatatatt aatagtaaat tttagcataa ataaattttt ttgtcaatgt 1452121 ttttgctctt aactggacgc gcgatccttc acatagccac gtgacctgta gcagaattcg 1452181 tctatcaatt atgtggactg aatcattagc ttttataaaa tgcgcacttg cggctgcatc 1452241 cctctttatg caaatcagga gcggttttct gtctcatggc agcatctttt cgtcgtttca 1452301 gctgagagag aaatcaagat atgtaacaat aaaagcctga gggatctcag gcttttccta 1452361 atattacaat ccaacagcat tccaggctgc ttcaacttta gcggcatcag ttgagccgta 1452421 gaggtcacgg gcagactgaa tgagagctgc cttggcatct ttgaacgtgg aagaaggcgt 1452481 gaggtacgtt gttaacgcac ggtaatagat ttgctgtgat ttagatacac caagttttgt 1452541 gatggtgttg taagcggctt tgtttggaat tccgctgttt gtgtgtacac cgccataatc 1452601 gccttcatct gtgtttggaa ggtttcggta attggcgtaa ttgtcaggct ggttgtattt 1452661 tgtagggttg gacaggctgc gaagagcagg ctggctgacc gtaatgtctt caccgatgtc 1452721 ccagtcttct gtatcgttaa aatacccgaa tacgtcagag aaagactcgt ttaatgcacc 1452781 tggctgattt tcataaatca agttggctgt ttcttgggtg acgccatgtg tcatttcatg 1452841 cgctgtcaca tctaatgagc cggaaagcgg agagaagaat gaaccgtcgc catcaccgta 1452901 aatcatctgg tctcctgtcc atgcagcgtt attgtattga gtgccgtagt gaacggaaga 1452961 aacgatttta ctgcctttgt tatcatagct gtttcgttta aagtttgaat aaaaataatc 1453021 gtacacttta ccgaggttat agtgtgcgtc aacggctgcc cgctgtgatg aagatgtaaa 1453081 tgttttcgtt gtgcttgaga caagcgtgcc cggaaggcgg ctttgtctgt tttgcaaatc 1453141 atatgtgatg atttgggtgc ctgttggttt tgaaagatct cttagaacat attttccgcc 1453201 ttcataagag atgttcaaag gaacagttgc gccctttagc gttgttccgc ttccagtggc 1453261 ggcggcatgt tctactttat tttgctgttt taaaatgctg cctgtttcgg cgtcaactaa 1453321 gacttcccag tttgcaggtt caggctcgac atagcgaatc gtcacgtcgt aagcaagacg 1453381 atagctgccg tcttttgttt ctatcgcttt taattcggct ttattgctgt ttttggccgc 1453441 tccgttagaa acagcgtctg gtgatttgcc gatagctttg aaagcgagtg ccagcgcttt 1453501 ttcagaagag actttttggc tgttatctgt ttttgcagca gattgattgt gtaattcacc 1453561 attgaccgca tagacattat cggatttatc gacgtgaacg atcacttgcg aatctttaat 1453621 tggcactccg ttaacgacag gcgcatatcg aaagtgcttg tatccaaggg catcagtcgt 1453681 gctttcaaca agcttcagcc ttttggaagg gtcaccttta aaaatgttgc tgttcttttt 1453741 caaaaactgc ttgacagcct tgtcatttgg tgcagagagt tctgattgcg caatcgcgtt 1453801 tttggagagg aaatttgttt gattctcttt aagctgatga ccttcagcag cctgaacacc 1453861 tggcaggctg attgataaac tcataaacga agcagcgaca gcaacagaca atttcttacc 1453921 taaacccaca ataaatcccc ctttttgaaa atactgaaaa ctttatattg ttatattaaa 1453981 ctagcattct ggaatactca acaaaaacta acataactag acaaaattga tagtattgtc 1454041 ctgtgtttgt ttttgttgaa taatatcaag atgagtcaag tgtcatgtgg tggttcattc 1454101 aagagttatg ttttttacat atcaagggga agatgagata tttttgtttc atcttgaaac 1454161 tttttgaaaa gtccgctgtc taaccgaatg aggccttaat aagaagtaaa ggattgttgt 1454221 tcgtgttgga gttattcagt cattatgtat tgcatttcga acgttatttt atattaagca 1454281 gacaaagcac cctgctgatt caatggtcaa ttgttgttct ggcgggctta tatcttttgg 1454341 tgcatcatcc caaaataaac cggcagcgca caatgttctt ggcgggtgtt atattgcgga 1454401 ttgtgctgct ggcgggagtg tctgttgaac ttattcacca ggtgcaatca acaaacttca 1454461 ccagcgctta cttaagagag gacggaaaag aactgctgcc gctgctgcat tttttgttat 1454521 acggatatgt gctgctgacg gcttttcact atatgctgat gccgcgtgat catggcggaa 1454581 agggtaagtt ttatacgttc gaccttgctg ttgtcagttt gccgatcgta caaatgattt 1454641 ttagtttctt ttcgtattgg aaggaatacc cggatgggat ggagccgatt gcattcgtgt 1454701 ttctgttttt catcatcact cttcccattg cgttgaatgt agtgtttttc aagctgtatt 1454761 ggagaacgga taagatctta ctaggcttat tttatacgct gattatcgga ctgcttgtct 1454821 tgctgcttgc gccatatccc aatcaaatct caaaagatta tggtgcagta atgccatata 1454881 cgatttattt ggcaatggcg ggatttttga tgagctatca tctgttccaa aagtcaggaa 1454941 aggtttatgt gcgtgtgaat aagtgggtga cgatggctgt catggtgttt tttgtcctgc 1455001 tgttaaatcc gatatataac ataggaacgg ctgctttcgc tgtatcaaag ccagcaaatg 1455061 tccatgattc attcaatttt gtcggggagc acatttcatc agaaaaagcg gaacagatac 1455121 taaagtcatt ttttcctacg gatgaaacac tttatttgca cgatacaaac atggatgtgc 1455181 attatttcta ctcatttgaa agcaaaggtt acaaagctga ggtagatgaa gtatcgcagc 1455241 taattcgtaa ttatgaatac ttacaaaaag cacatgggaa aaagctaacg aatcaggagt 1455301 acaagcgaaa gtccatcgct ttccttgagc gacacggacg tgtgttacat aaggatcata 1455361 tcgaaacaaa ggtatctcaa gaagacggcc agacagtcgt acgtatttac ctgaaaaatc 1455421 aacttcataa aaaagatcat gctgatgatg gcgcggtatt ttattgggaa aaggaaacct 1455481 taatggggtt tagtgaagat ccttcgattt atcagcttga ctctcttctg catgttcata 1455541 taacggaaca agacattcac gacaaagtgg aacaaatgtt tacagcgctg aacatatcaa 1455601 aacagcctta tcagatcact gatattgaaa gcgacagcct gcttggaagc atggtgagag 1455661 ttgaaacaaa agttggaatt gttttggaat ttgagggcga atcaggttgt ttacatagtc 1455721 tttcgcttcc gatgaaaaag aatatctcaa tggctaacag ccggctgcag catcagatat 1455781 tatcgatctt cgatgctcgt ggatcagaaa agaagaaaaa aagcagtcag ggtgacatgg 1455841 tgatgtatac tgattcttct aaaacatatg agtttgttga agctcaaggt cagctaaacg 1455901 tttatgtata cagcgataca cctgatcagt cattccccta tacgtatcgt aatggaacat 1455961 tggcttacga aaaagtagct tctctatatc aggatgtcat ttacaaaaag cgtatgcgtc 1456021 cgattatcgt tcaaagaggg gatgaacggc attatgcatg gctgatcatt attcagccgt 1456081 ttggttcaaa tcgccatgat gcctatgtag tggatggaga aacacaagag gtgaaaagtc 1456141 tttatgaatc ataaagaaaa agagtctgtt tttgtagact tatacgacct gtataaagaa 1456201 ggagagctag aggatgaatc aatggaatgg atgaaacagc atgaatccct atttcaaaag 1456261 aatgcggaag acttaaagag taaaacttgt ttaaagagaa gtcccggtgc tgaagaagaa 1456321 agccaaatca gatatatgaa agtatacctg tcttccatgt atatctgttt cattttattg 1456381 gccatttgga tgacggtgtg gttttatttt taatgaagca tagggattcc attgaggact 1456441 tgtatcggca gtattatcaa gaaattttaa attatttatt cagaaggact catcatcttg 1456501 aaacagccaa ggacttagcg caggacacgt ttgtaaaagc tcttaacggt ctggcttcgt 1456561 ttagggggca ttcttccatc agaacatggc tctacaccat tgcgcatcat acctttatca 1456621 attggtaccg aagggatgtc aaataccaat ttactgaaat cagcaaaaat gaagggttaa 1456681 cgcaaacaac ttatgaccag cctgaacagt atctgtcacg gacggtgaaa agcgaaacac 1456741 tgcggcagga gctcctgaag ttaaaagatc agcatcaatc cgttttgatt ttaagagaat 1456801 tccaagagct ttcttatgaa gaaatcgctg agatattagg atggagtctt tctaaggtga 1456861 ataccacatt gcaccgggct agattagagc taaagaaaaa catgacgaaa agtagagagg 1456921 aggagcggat atgacctgct ttctagtaag agacctgctt cctctgtatc ttgaaggtga 1456981 ttgtaaaaga gaaacggaac acgttataga agagcattta aaaatgtgca gcagctgcag 1457041 agacatgtat gacacgatgg ctgagccatt tgaattggaa agcgaacagg ccgttgagga 1457101 ggcttatctg ccggaagaag aactgcgttt taaacagagg tactatggat tactgatcat 1457161 gaaagctgcc tgctggtttg gagcggcggt tgccatgatg ctgatcatca aactgctgat 1457221 ataaaaaaag cgcttgtccg attccggcaa gcgctttttt acattaagcc tggggatgaa 1457281 tcatatcgta aatagcggca agctgttctt gtgacagggc actgaagagt ttttcataaa 1457341 cgtcagcttg cagtggcgtt gcacctgctt gtagcgctgc gtctttatca tagctgtaca 1457401 catcatcttg tagcacaatg gctgcttgaa gaatgtgaat cttgagagaa acagcggaga 1457461 aaaattgttc aagtgcaagt gcttcttttt ctgtgaagcc aagttcaact gctttttctg 1457521 tatcaaattt gtaatttcca tcctcgagat acacacattg tgaaacaatg ctgaaaaatt 1457581 ctgatgtcga ttcccagagt gtagcaatta cctgagcctc ttcttttgtc attcctaact 1457641 cgacagcttt ttcgctgtca aaataatata caccgtcttg ttcgtatata cattgattta 1457701 atatatcaat gaatgtattg agatcttcgt tagtgctcgc ctgatgctgg agttgaacag 1457761 cagtgttatc aaccggtgtt tttgcgctgg ctgcatcagg accgaacgtt aatagagcag 1457821 ctgaggtcat tgcggcagtc gttaacatag ctttttttac aaatgttttc ttcatgtttc 1457881 ttctctccct tttatgaatt gtgctacaaa ttccattata gggagtagtt tccggtggag 1457941 gaataggcgc tatggtattt tatgtgtatc gttgccgaac tactttttga aggctgcacg 1458001 tgtgatcgtt agaacgattg tctatgtatg aaggctgttt tgcatcttcc tgactaagaa 1458061 acaggggaga taaggcttaa agaaatgaaa aacaccgctt tctttgcggt gttttttgat 1458121 tacaatgtcg ccggcggggc aatgctttta atcaagcaag ccttgttcgc gcattttctt 1458181 ttttaatgta aatccgccgc ccatgacagc gcaaacaagt acaatgctgg cgataatgcc 1458241 tgcagggctt ttttcagcga taaagacgcc gatcagcata atgctgaaaa ccgctgcaaa 1458301 tgcaaataat agtaaaagcc aattcatttt tttcataaat tccatcccct tttacgtctt 1458361 atattaagtt tacagaaaaa cgtgacgctt ttaaagagga tgtgtgatat aatatgaaag 1458421 ttatctaatt tttttaggag atgaaaaagt gaaacttcga aatgatcttc gcaacatcgc 1458481 gattattgcc cacgttgacc atgggaaaac gactctagtc gatcagcttt tacatcaggc 1458541 tggtacgttc cgtgccaacg aacaggttgc tgaacgcgca atggactcta atgatcttga 1458601 acgcgaacgc ggcattacaa tattggcgaa aaatactgcg attaactata aagatacacg 1458661 tatcaatatt ttggacaccc ctggacatgc agactttggg ggagaagtag aacggattat 1458721 gaaaatggtt gacggcgtag tgcttgtcgt tgacgcatat gaaggctgta tgcctcaaac 1458781 tcgttttgtt ctgaaaaaag ctcttgagca aaacctgaac cctgttgttg ttgtaaacaa 1458841 aattgaccgt gactttgctc gtccagagga agttatcgat gaagttctgg atctgttcat 1458901 tgagcttgat gccaatgaag agcagctcga gttcccagtg gtatatgctt ccgcgattaa 1458961 tggaacagcg agtcttgatc cgaaacaaca ggatgaaaac atggaagctt tatatgaaac 1459021 cattattaag catgttccgg cacctgttga taatgcagag gagccgcttc aattccaagt 1459081 tgcccttctt gactacaacg actatgtagg ccgtatcgga atcggacgcg tattccgcgg 1459141 cacaatgaaa gtcggacagc aggtttctct tatgaagctt gacggaacgg caaagtcatt 1459201 ccgtgttaca aagatttttg gtttccaagg cttaaagcgt gtggaaattg aagaagcaaa 1459261 agcgggagac ctcgttgcgg tttccgggat ggaagatatc aacgttggtg aaacggtatg 1459321 tcctgtagac catcaagatc cgcttccggt ccttcgcatt gatgagccga cacttcaaat 1459381 gacatttgtc gtgaataaca gtccgtttgc aggccgtgaa ggcaaatatg taacggcccg 1459441 caaaatcgaa gagcgtcttc aatcacagct tcagacggat gtgagcttgc gtgttgagcc 1459501 aacagcttct cctgatgctt gggttgtttc aggacgcggt gagctgcact tgtcaatttt 1459561 aattgaaaat atgcgtcgtg agggctatga gcttcaagtg tcaaaacctg aagttattat 1459621 caaagaaatc gacggcgtac gctgtgagcc tgttgaacgt gtgcaaattg atgttcctga 1459681 agagcatact ggctctgtaa tggaatcaat gggtgcccgc aaaggcgaaa tggttgatat 1459741 gatcaacaac ggaaacggcc aagtccgtct catctttaca gttccttccc gcggattgat 1459801 cggttactct acagaattcc tatcattaac acgcggattc ggtattttga accatacgtt 1459861 tgacagctac cagccgatgc aggcaggcca agtcggcgga cgccgtcaag gtgtacttgt 1459921 gtcaatggaa aacggaaaag caacatcata cggtattcaa ggaattgaag accgcggtgt 1459981 catcttcgtt gagccgggta ctgaagtata cgaaggaatg atcgttggag agcataaccg 1460041 tgacaacgac cttgttgtta acgtcagcaa aatgaaacag caaacaaacg tccgttctgc 1460101 gacaaaggat cagacaacta caattaaaaa agcgcgcatc atgtctcttg aggagtctct 1460161 agagtactta aacgaagatg aatattgtga agtaacacct gaatccatcc gtttaagaaa 1460221 gaagatcctc aataagaacg aacgtgaaaa agcagctaaa aagaaaaaaa cagcaggatt 1460281 gtcttaatct cgtgcagaat ttgaaaagat agaacccgta cgtttacagg ggagggaatc 1460341 tttttgaatg acgtaagcga acgcctgtcg ttcttcgccg ctctatatca agtagaccgg 1460401 cagcctgcgg caggcatgtg gctgctgtac ggcacgattt ttgtgttggc cgttattgta 1460461 tttaagcttg gatttgctaa acggcttcct gtattaaaat ctgcagtggt gtatgtattt 1460521 ttggctttgg gctgcactgt tttgactttt ttaggggtgt ttttgcccgt ggcagaagga 1460581 ttggtcgtcg ctgcgctgat tttaatcatt tacaaaatcc ggctgtatca gtcgaaaaaa 1460641 ggacagtctg caaaatcata aaagactcag ctgaaagctg agtctttttt gtgttctgta 1460701 tggttaagcg gccgctttat tttttgactt tttctttttt ctgctgtccc gggtgaaaag 1460761 taaattttcc cgttttcagc cgttcctctg tttttttggc aatccgatcg tggcattcct 1460821 ggcacatata tgtatggatc gggcggtttc gaagccgttt cgcgatcagg gtatcatcat 1460881 caattgtttc aattttatcg caaatagaac atttgaccct catcatatca cctctttcac 1460941 taacatgtat tataccacgg atcagaagct gtccaaaata agaaaaagct aaagcgcaag 1461001 gctatagctt agtcattgtt gttctttttc atatgatgat cagattgatc gttttgttcc 1461061 ttctccattt cctgttgctg ttttctattt aattggtcat tttgctgctt tgtttgcggt 1461121 tcatcttcat tgtcaatcac atcgttaggc acttcgggaa gcactcggcc gacaattgca 1461181 gctaattcat ccagtatacc tgttaccgga tggccctcgc tgatttctct gctcatttcg 1461241 cgaaggcggc tgaccgtatc gggatcagca atgactactg cgttggcgcc atatcgatca 1461301 ttctttagcg cctgagctac agaatattta atggtttcca ctttgcttct gtccaaagta 1461361 tcatcgacat caatcccaac aacagcatag cctcccagca caacggctgt tgcatccttg 1461421 acgtcggggt ttttttcagc aacgctgaca agatgcttgg caatatccgt tcttgttcca 1461481 ttgtcttttg tttcttgagt tgtgtccttt acgtgaatcg gtttagtctc ctgctgtctt 1461541 gttgattctt tttcaacatt ctggccctgt tttccttgtt gataggcaca agcggacagg 1461601 ataagtgtca gctgtatgat aatgaaaaga attcgcactt gcgggttccc tccttaaaat 1461661 gctttcatta attttattgt tgaattaacc ttctatcttt atgcacaaaa acatatattt 1461721 tagcaggcat tcaccttttt catcaaaaga gaagcaggaa gaactttgac ccttatatca 1461781 ggaggctgag acttgagtaa aatttatgtg ttagatacga atgtgttatt acaggatcct 1461841 aacgcgatat tttcttttga agaaaatgag gttgtcatcc ctgctgtcgt tttagaagag 1461901 gttgattcaa aaaaacggta tatggacgaa gttgggagga atgcaaggca cgtatctaag 1461961 ctaatcgatg cgctaagaca aaagggcagg ctgcatgagc atgtaccgct tgacaccggc 1462021 ggcacactga gaattgaact gaatcatcgt tcgtttcacc agctgcaaga gatctttatt 1462081 gaaaagacga acgataatcg catattagcc gttgcgaaaa acttaagcct cgaggaagaa 1462141 accaaggaaa atggcaggcc ggttatcctt gtcagtaagg atgtactggt cagggttaaa 1462201 gccgacgcaa tcggactgct tgctgaagat ttcttgaatg accgggttgt ggacaatgat 1462261 gaaatgtaca gcggctataa agatttatat atcagccagc agctgttcag ctctttttac 1462321 gggaaaaatc aaatttcagt aaacgatgtg aaacagcatg cgttttatcc gaatcagttt 1462381 gctttaatga aggatgagct aggagggtcc tcctcggcag tcggaattgc agacaaaacc 1462441 ggaacggtat taaaaagact cgtatttgat gatgaacata tatggggaat caggccgaaa 1462501 aatgtacagc agacaatggc attagagctt ttgctgcggg aagatattcc gcttgtcacc 1462561 ctgatcggca aagcgggaac cggcaaaacg ctcttagctt tggcggcagg gctattacag 1462621 acagaagact tgggaatata taaaaagctg gtcgtcgcaa ggccgattgt tcctgttggc 1462681 aaggacatcg ggtatttgcc aggcgaaaaa gaggaaaagc taaagccttg gatgcagccg 1462741 atttttgaca acttagagtt tctgtttaat gcgaaaaaac caggggagct tgatgctatt 1462801 ttggcgggaa ttggctcaat tcaggtagag gcgctgactt atatcagagg gagaagcatt 1462861 ccagatcaat ttattatcat tgatgaagcg caaaatttga ccaggcatga ggtgaaaacg 1462921 ttgctgacga gagtcggtga gggcagtaaa attgtcttaa tgggcgaccc tgaacaaatt 1462981 gatcacccat atttagacag tctgaacaat ggtttggcct atgtggttga gcggtttaaa 1463041 ggacaaccca tctcaggcag cgtgaagctg ttaaaaggtg agagatcagg tctcgcccag 1463101 cttgcagctg atttgctgta acacttaaat gatttcgatc tcttttacat cggtaatcgg 1463161 ctgtttgtga tgaaccgggt cttcaaagta aatatgcacg gggccgcctt cttgaatcgg 1463221 cttgcctgcc tcactgaaat ggacaatact gttcagagcg gtttccagag aaacggcggc 1463281 ctttcccgaa cttgtgacaa atacacattg tgtcgcagag ctgttcggct cagcattttt 1463341 caggacagtc ccaagtctca ttgcgaaact gccgttcatc agtttttgct tctcatattg 1463401 cttttccgtc tttaatgtag gcggcgcgat tcgcccctct ctgatgacgc gttccggatc 1463461 aaggtcggat tcatccccgg ctgattgtaa atatgtgtct tgactgtccc ctttgcggtc 1463521 aaacgaaaat ttgcgatcat caaaaatcca tacgcttgga tcaatggtaa ttggatatgt 1463581 aacattgcct tttacttgga taacgctcat gatatgaccc ccttctctca aaattataaa 1463641 agttttcgca tgaattgtca ctttgtgtac aaattatgtg tattgaaatg ctgagggaac 1463701 gagggtgttt gcatggtatg ccagcataat gatgagcttg aagccttagt gaaaaaggcg 1463761 aaaaaagtaa cggacaaggg ggaggtagcc agctatattc ccgccttggc aaaagctgat 1463821 aaacacgacc tgtcagtggc gatttattat tccaataatg tttgtctgtc agcaggtgac 1463881 gtagaaaaaa catttacgct tcaaagtata tcgaaagtcc tttcccttgc tttggtgtta 1463941 atggaatacg gcaaagataa ggtcttcagt tatgttggac aggagccgac cggtgatccg 1464001 tttaattcaa ttatcaagct cgaaacagtg aatccgagca agccgttaaa ccctatgatt 1464061 aatgccgggg cattggtagt gacaagtctg ataaggggaa gaacggtaaa agagagactt 1464121 gattatttgc tttcttttat cagaaggctg acaaacaacc aagagattac atactgccgg 1464181 gaagtggctg aatctgaata cagcacttca atgattaatc gggcgatgtg ttattatatg 1464241 aagcagtacg gcatttttga agatgatgta gaggcagtaa tggatttata tacgaagcaa 1464301 tgcgcgattg agatgaacag cttggattta gcgaaaatcg gatctgtatt cgcattgaac 1464361 ggcagacatc cagagactgg ggagcaggtc atctcaaaag atgtcgctag aatttgcaaa 1464421 acgtttatgg tgacgtgcgg aatgtacaat gcaagcgggg aattcgcaat taaggtcgga 1464481 attcctgcga aaagcggcgt atccggcggg ataatgggca tttcgcctta cgatttcggg 1464541 atcggcatat tcggccccgc attagacgaa aaagggaaca gcattgcagg tgtaaagctt 1464601 ttggaaataa tgtctgagat gtacaggctg agtatttttt aatttatgtc atatgcttaa 1464661 atcctcttgc attttctgtt gatacccttt atgataaata gaagaattag gtactcgcct 1464721 ggggaacgga gggatacttt tggcttcaga gatgatagtt gaccatcggc aaaaagcttt 1464781 tgaactctta aaagtggacg ctgagaagat tttgaagctg atccgagtac aaatggataa 1464841 cttaacgatg cctcaatgtc ctctatatga agaggtttta gatactcaaa tgttcgggct 1464901 ttcgagggaa atcgattttg ctgtccgcct gggattggtt gatgaaaaag acggtaaaga 1464961 ccttttatac acattggagc gcgaattgtc tgctttgcat gacgcgttta cagctaaata 1465021 aatgataaaa ctcaaactta ttaacagttt gggttttttt ataaccgcta tttttctctc 1465081 atctcataaa agacggtctt tttttacaca ttccttccga atcgtataga gattcttcgt 1465141 ctcgtttgat aaattgtagt aaaataaaaa agataaatac ataaaaacca tagataatgg 1465201 aagttagaag cagggaagag gatgttatgt taaaaaaaat gctaaaatct tatgattact 1465261 cactgatatt cgcaatcgtt ttattatgcg gattcggttt agtgatggta tacagctcaa 1465321 gcatgattac ggctgtctcc cggtatggag taagcagtaa ttttttcttc atgcggcagc 1465381 tgtttgcttt aattgcgggt ggcgctctat ttattctcat ggcgttgttt ccttataaag 1465441 cactggccca tcaaaagttt cagaagggga tactgcttgt atctgttctt gcgcttatct 1465501 cactgtttgt tttcgggcat gttgccggaa acgcgcagag ctggtttaaa atcggcggaa 1465561 tgagtattca gccgggggag tttgtgaaac tggtcgtgat tttatacctt gcagccgtat 1465621 atgcaaaaaa acaaagttat atcgaccatc tgttaacggg agtagcccct ccggtagtca 1465681 tgacgcttat aatttgtggg ttaattgcca tgcagccaga tttcggtaca gccatgatta 1465741 tagggttaat tgcgacgtgc atgatcttgt gctccggctt cagcggaaag acgctggtga 1465801 ggcttgtgat actgggcgga attgttttca ttttagtcag ccctattatc tatttgaatc 1465861 aggacaaaat tttaactgaa ggccgtttag cgcgttttga gagtcttgaa gacccattta 1465921 agtatgcaaa ttcatcaggt ttgcaagtga tcaattctta ttatgcgatc agctcaggcg 1465981 gcattttcgg cctggggctc ggtgaaagta tccaaaaata cggatatctg cctgaatcac 1466041 acactgactt tattatggct gtcattgctg aagagctcgg catttttggg gtattgtttg 1466101 tgattttctt attgggtttt gtcgtcataa aaggttttta tattgccaga aaatgcgagg 1466161 acccgtttgg aagtcttctg gcgatcggca tttcaagcat gattgccatc cagtcgttta 1466221 ttaaccttgg cggtgtcagc ggattaattc cgattacagg ggttacgctg ccatttatca 1466281 gttacggggg ctcttctttg gtgctgctgc tggggagtat ggggatatta gcgaatatca 1466341 gcatgtttgt gaaatattca gagaataaga aaaagaaaga gcccttggcg ccgaagggaa 1466401 tgaaaaagaa acagctcaaa aaaactgttt atctgtaaaa aacaagtgtg tacaggggaa 1466461 ggatattccg ctatgataga ttatattcca ttcgggtaag ggggagaaaa gtttgtctca 1466521 gcaatcgata caaaaagtat tagtagcaaa caggggagaa attgcaatcc gaatattccg 1466581 ggcgtgtacc gagttgaata ttcgtacagt tgcggtctat tcaaaagaag attccggttc 1466641 ctaccatcgg tacaaagcgg atgaagcata cttggtcggt gaagggaaaa aaccgattga 1466701 tgcttacctg gatattgaag gtatcattga tattgcgaaa agaaacaaag tcgatgcaat 1466761 tcatccggga tacggtttct tatctgaaaa tattcatttt gcgagacgat gtgaagaaga 1466821 aggcatcgta ttcatagggc caaaatccga gcatctcgat atgtttggtg acaaggtaaa 1466881 agcgcgtgag caggcagaaa aagcgggaat ccccgtgatt ccgggaagcg acggtcctgc 1466941 cgaaacgctt gaagccgtcg aacaatttgg acaagctaac ggttatccga tcatcattaa 1467001 agcctcgctt ggcggcggcg gccgcggtat gcggattgtc agatctgaaa gtgaagttaa 1467061 agaagcatat gagcgtgcta aatcagaggc gaaagcagcc tttggcaatg atgaagttta 1467121 tgtagaaaaa ttaattgaga atccgaaaca tattgaggtt caggtcattg gagacaagca 1467181 gggcaatgtc gtccatcttt ttgagaggga ttgctccgtt caaagacgcc atcaaaaagt 1467241 cattgaagtg gcgccgagtg tctcgctgtc acctgaatta agggaccaaa tttgtgaggc 1467301 tgcagttgcg cttgccaaaa atgtaaacta tataaatgcg gggacggtcg aattccttgt 1467361 tgcaaacaac gagttctact ttattgaagt aaatcctcgc gtacaagttg aacacacgat 1467421 aacagaaatg attactggtg tcgatattgt tcaaactcag atccttgttg cccaagggca 1467481 cagccttcac agcaaaaaag taaatattcc tgagcaaaag gacattttta caatcggcta 1467541 tgccattcag tcacgggtta cgactgagga tccgcaaaat gatttcatgc ctgatacagg 1467601 aaaaatcatg gcttaccgct caggcggcgg ttttggtgtc cgtcttgata ccggaaacag 1467661 cttccagggc gccgtgatca caccatacta tgattcactt ctcgttaagc tttcaacttg 1467721 ggctttaacg tttgaacagg cagctgccaa aatggtgcga aaccttcagg agtttagaat 1467781 cagaggcata aaaacgaaca ttccgttcct tgagaacgtt gcaaagcatg agaagttcct 1467841 gacagggcaa tatgatacat ctttcattga tacaacgcct gaattattta atttccctaa 1467901 acaaaaagac cgcggaacga aaatgctcac ttacatcggc aatgtgacag tgaacggctt 1467961 ccctggaatc gggaaaaaag aaaaaccggc gtttgacaaa ccgttaggcg taaaggtaga 1468021 cgttgatcag cagcctgcca gaggaacaaa gcaaattctc gatgaaaaag gtgcagaagg 1468081 gcttgcaaat tgggttaagg agcagaaatc tgtcctttta actgatacga cattcaggga 1468141 tgcccaccaa tcgttattgg caactagaat cagatcgcat gatttgaaaa aaatcgcaaa 1468201 tccgacggct gcgttatggc ctgaactatt cagtatggaa atgtggggag gcgcgacctt 1468261 cgatgtagcc taccgattcc tgaaagaaga tccgtggaaa cgtttggaag atcttcgcaa 1468321 agaagtgccg aataccttat tccagatgtt gcttcgctca tcaaatgcgg tcggctatac 1468381 gaattatccg gacaatgtga ttaaagaatt tgtgaagcaa tcagctcaat ccggtattga 1468441 tgtgtttcgt attttcgaca gcttaaactg ggtaaaaggg atgacgttag ccattgatgc 1468501 tgttagggat accggcaaag tggcagaagc tgcgatttgt tatacgggag atatccttga 1468561 caagaaccgg acgaagtacg accttgcata ttatacatcg atggcgaagg agcttgaggc 1468621 ggccggagcc catattctcg ggattaaaga tatggcaggg ctgttaaaac cgcaggctgc 1468681 atatgagctc gtttctgcgt tgaaagaaac gatcgacatt ccggttcacc ttcatacgca 1468741 tgatacgagc ggaaacggta tttatatgta tgcgaaagct gttgaagccg gcgttgatat 1468801 catagacgtg gcggtcagct caatggcggg attaacgtca cagcctagcg cgagcggatt 1468861 ttatcatgcg atggaaggca acgaccgccg tccggaaatg aatgtccaag gcgttgaatt 1468921 gctgtcccaa tattgggagt cggtgcgtaa atattatagt gaatttgaaa gcggaatgaa 1468981 gtctccgcat actgaaattt atgaacacga aatgccaggg ggccaataca gcaacctgca 1469041 gcagcaagcc aagggagtag gccttggcga ccgctggaac gaagtcaagg aaatgtacag 1469101 acgcgtgaac gatatgttcg gtgacatcgt caaggtaacg ccttcctcaa aagtagtcgg 1469161 agatatggca ctctacatgg tgcaaaacaa tctgactgaa aaagacgttt acgaaaaagg 1469221 tgaatcttta gatttccctg attctgtcgt ggagcttttt aaaggaaata tcggccagcc 1469281 tcatggcgga ttcccagaaa aactgcaaaa gctgatctta aaagggcagg agccgattac 1469341 agtcagaccg ggcgaactgc ttgagccggt gtcatttgaa gcgatcaaac aggaatttaa 1469401 agagcagcat aacttggaaa tttcagatca ggatgctgtg gcatatgccc tttatcctaa 1469461 agtcttcact gattatgtga aaacgacaga aagctatgga gacatctcgg tattagatac 1469521 accgacattc ttctacggta tgacattagg tgaagagata gaagttgaaa ttgagcgcgg 1469581 caaaacgctg atcgttaagc tgatttcaat cggtgagcct cagcctgatg ccacccgcgt 1469641 cgtttatttc gaactcaacg ggcagccgcg tgaagtagtc attaaagatg aaagcattaa 1469701 gtcttccgtt caggaaaggc tgaaagcaga ccggacaaat ccaagccaca tcgcagcttc 1469761 catgcctgga acagttatta aggtattggc tgaagcaggc acaaaagtca ataaaggtga 1469821 tcatttgatg attaatgaag cgatgaaaat ggaaacaacg gttcaggcgc ctttctcagg 1469881 aacaatcaag caggttcatg tgaaaaatgg tgagccgatc caaacgggag atctgctcct 1469941 tgaaattgaa aaagcataaa aaacaaagag tgtatatcaa tgatatacac tcttgttttt 1470001 tatatagaaa atgtggagtg aaacagatgg ttagaagaga tataagggga cttcagagat 1470061 tatagagtac tgtcacaagc ccaaaataaa aagaggctta tacagccaat attttagatg 1470121 ctttgtagta tgccgtgcat atttctttaa gcactatctg atttaaaagg ctttaatact 1470181 tatgttcgcg agctatagat ccatatgaaa tttctataat cacgatgaga aaggggacag 1470241 accgaagtga gccgctcact gatcatcaag ttcggcgaag gctggcgatt gaaacgcata 1470301 aagcgccaaa aaacaagaca taaaaaagac caaagccgcc taaggctttg gtcttgagtc 1470361 cttatgattg cctggattca taacggaaac gagcaatcaa taataagaag tagcatagaa 1470421 cgccaaacag acaggcaata aagaacgagt gggcaagtgc aaagcccaga gccagttcag 1470481 agtatacgat cataataccg gacagtgcct gtaatgtaat gaaaataaga catgagatcc 1470541 atccccaaaa gatctgtttt tgatctttat aggaagtaat agcatgaaca gcggcaacaa 1470601 taatccatac aaataaaagt aaggctgctg ctctgtggcc catttgcacc cattcatgga 1470661 attgggtcgg aagtccattg ttcagcgggc tgcacagcgg cacattagga catgccagac 1470721 ttgattcagt gtgtcttaca tatgcgcctg tatacacaac gatataggaa tatattaaaa 1470781 ttcctatcat gtgaaattgc atctttttgc cgatttgaag cggcttaacc agtgttctga 1470841 ctgatttatc agcttcaaat atgagcaatg ttaaaataag cactgaagca aaagaaatta 1470901 atgagatgcc gaagtgaagc gccataatca gcgcgttcga accgaatacg acagccaatg 1470961 cgccaagcaa tgcctgaaga aataaaaaga taattgacat gatcgcgaga aacgttgttt 1471021 cacgaaaaat cggcgtgatt tttctccatg accaaaacgc aaggcttagc acaaggataa 1471081 tagagattcc gcttgcgaat cggtggctcc attcaataat tgaagccgga ttcagttcag 1471141 ggaaaaaacg gccgtgacac agcggccact gtctgccgca tccttggccg gaacctgttt 1471201 ttgtaacgag ggcacccccg attaaaacaa ttagcatgac aaatgtcgtc agaacaccga 1471261 gagcttttaa tgctttattc atacaatatt caccttctta acatactgct gcaattttat 1471321 atacgttcca agtgtaagcg aatatgtgtt ttgtggcaat tcccagagcc ttttgttcac 1471381 aaaaatataa tagaatgacg gcttctggaa aatgtacact tgattattca tgccgggtct 1471441 gatagaaata aggtaaacgc aatgccgatt tggagattgc cttcatcttt ggtaaaattc 1471501 ataaaaagtt cacaaataaa ttcctgtttg tcgtttaata tttaatagga tgttttttta 1471561 caagatgtta tcttgtatga tagagttgca ggttatttta ttctcctgcg ttaggtttgt 1471621 aagggaggtt tacgttatgg ctaactccag aatcttaaat gatacagcta tagacggaca 1471681 aattgaagaa acaacggcat ggaaagattt tctgtccctt attaaaatag ggatcgtcaa 1471741 ttctaacctc atcacgactt tcactggaat gtggcttgca ctgcatatat ccggtttaag 1471801 ttttttaggc aatataaaca ccgttcttct tacgttaatc gggtcttcac tgattattgc 1471861 gggctcctgc gcgatcaata actggtatga ccgggacatt gaccatctta tggagcgtac 1471921 gaaagtaaga ccgacggtta cgggtaaaat tcagccgagt caggcgttat ggtctggaat 1471981 tttgctggtt gctttaggat tgatcatgct gctgatgaca actgtcatgg ctgctgttat 1472041 cggttttatc ggagtcttta cgtatgttgt attgtacaca atgtggacga aacgccgcta 1472101 tacgattaac acagtagtag gaagcgtttc cggtgcagtg ccgccgctta ttggatggac 1472161 ggcagtggaa gggaatatcg gtgtcgtagc atgggtgtta ttcatgattt tatttatttg 1472221 gcagattcct cacttcttag cattggctat taagaaaact gaggattaca gagctgcaaa 1472281 tattccgatg cttcctgtcg tatacggatt tgaagtgaca aaaagacaaa ttattgtgtg 1472341 ggttgcgtgc ctgatgccgc ttccgttttt ccttggtagc ctgggtcttc cgattgtcat 1472401 tctcggcttg ctgttaaata tcggctggct gattcttggc ttaatgggat tccgctccaa 1472461 gaatatcatg aagtgggcaa cgcagatgtt cgtttactcg cttaactaca tgacaatcta 1472521 tttcgttgcc atggttgtct tgacgctttt ctaaaaaata gatatgatgc ttgttttatc 1472581 gcttcaaaat aaacgatgac aactagtaaa tgccgccttg acctcttgtt taatcaggcg 1472641 gctttacttt tatacataga tggcattttg agtaaaaaaa ctcataattt aagagaagag 1472701 gaaatgtaag tgctttattg gtgataggtt ggatggcgat agatttcgat ccgctttccg 1472761 cctttgtatt gaccagaaaa ggggttgggt gaaatggtaa agcattggcg tcttatttta 1472821 ttattagcct tagtgccgct tctattaagc ggatgtggaa aacctttttt atccacgctc 1472881 aagcctgctg gcgaggtggc tgataaacag tatgacctga cagtgctcag cacattgatt 1472941 atggtggttg ttgttgcagt agtatctgtt atcttctttt atgtgattgt gagattcaga 1473001 agatcacggg tcggtgagaa cacgataccg aaacaggtag aggggaataa atttttagaa 1473061 atcacatgga ccgtgatccc gattttgctg ctcattattc ttgtgattcc tgttgtatta 1473121 tatacgctgg agctagcgga cacatcacca atggataaaa aaggccgcaa agctgaggat 1473181 gctcttgtag tcaatgttag ggcaaattta tactggtggg agtttgagta ccctgattac 1473241 ggcattatca caagccagga gctgattgta ccgacagatc agcgtgtata ttttaattta 1473301 aaagcctctg atgtaaaaca ttccttctgg attccttcag ttggaggaaa acttgatacg 1473361 aatacggata atgaaaataa gttcttcctg acatttgatt caaaacgaag caaagaggca 1473421 ggagatatgt tttttgggaa gtgtgcagag ctttgcggcc cttcacatgc gctgatggat 1473481 tttaaggtga agacgatgtc tgcaaaagaa tttcagggct ggacaaaaga aatgaagaac 1473541 tataagtcta cagcagagag cgatttggct aagcagggtg aagaactgtt taaagagaaa 1473601 aactgcctga gctgccatgc ggtagagccg aatgataagc gtgcagaagc cgctagaacg 1473661 gcacctaact tggcgacctt cggtgaaagg acaaaagtgg caggggtgaa agaggccaac 1473721 aaagaaaatg tgaaggcttg gctgaaggac cctgacagca taaagccggg gaacaaaatg 1473781 acaggcacat atccaaagct ctcagacagc gaaacaaatg cgctttatga atacttaaaa 1473841 ggcttaaaag cggaaagcaa gtagggaaga aagggagata ttgggggagg tcacatatgt 1473901 tgaatgcgct tacagaaaag cggacgcgcg gatctatgct ttgggattat ttgacgacgg 1473961 tggaccataa aaaaatcgca attctttatt tagtggcagg gggattcttc tttcttgtcg 1474021 ggggaattga agcgatgttt atcagaattc agcttgcaaa gccggaaaat gcgtttctca 1474081 gtgctcaagc gtacaatgaa gtaatgacta tgcacggaac gacgatgatc tttctggctg 1474141 cgatgccgct cttatttgcc ttgatgaatg cggttgtgcc tttgcagatc ggggctcggg 1474201 acgtttcgtt tccattttta aacgcgcttg gtttttggct cttctttttc gggggcattt 1474261 tcttaaatct aagctggttt ttgggcggag cgccagatgc gggctggaca tcatatgcct 1474321 cactttcgct tcattctaaa gggcacggca tagacttttt cgtcctcgga ctccaaatat 1474381 cggggctcgg gacgctgata gccgggatta actttttggc cacgattatc aacatgaggg 1474441 ctccgggcat gacgtatatg aggctgcctt tgtttacatg gacgacattt gtggcctcgg 1474501 cattgatttt gttcgcgttt ccgccgctta cggttggatt ggctctcatg atgctggatc 1474561 ggctgttcgg aaccaatttc tttaatccgg agcttggcgg aaatacggtc atttgggaac 1474621 atttattttg gatcttcggc cacccggagg tttatatcct aattttgcct gcattcggta 1474681 ttttttctga ggtcatccct gtgttcgcca gaaagcgttt gtttggctat tcttcaatgg 1474741 tttttgcaat cgtgctcatt ggctttctgg gctttatggt ttgggtgcac cacatgttca 1474801 cgactggtct cggcccgatt gcaaatgcga tttttgcggt tgcaacaatg gctatcgcga 1474861 ttccgaccgg gattaagatt tttaactggc tgttgacgat ttggggagga aatgtgaagt 1474921 atacaaccgc tatgctgtat gctgtctcat ttattccatc ctttgtgctc ggcggtgtga 1474981 cgggagtcat gctggcagct gctgcggctg attatcagtt tcatgatacg tattttgtgg 1475041 ttgcgcactt ccactacgtc attattggcg gcgttgtatt cggcctttta gccggtgttc 1475101 atttctggtg gccgaaaatg ttcggtaaaa ttctgcatga aacgatgggg aaaatttcat 1475161 ttgtattgtt ttttatcggc tttcacctca cgtttttcat tcagcatttt gtcggcttaa 1475221 tggggatgcc gcgccgggtt tatacgtttt tgccaggaca gggtctggaa accggcaact 1475281 tgatcagtac aatcggggcg ttttttatgg cggcagctgt tattcttctg ctggtcaatg 1475341 tcatatggac atcggtaaaa ggtgaatatg taggtgctga tccatggcat gacggacgta 1475401 cgctggaatg gaccgtttct tcaccgccgc cggagtataa ctttaaacag cttccttttg 1475461 tcagaggact tgatccgctt tggatcgaga agcaggcagg gcacaaatca atgacgccgg 1475521 cggaaccggt tgatgatatt catatgccaa acggctcaat cctgccgctc atcatttcct 1475581 tcggcctttt tgtcgcagcg ttcgggctgc tgtacagaag tgattacgct tggggcctgc 1475641 cggtgatctt tatcgggctc ggcatcacat ttattacgat gctgcttcgt tcagtaattg 1475701 atgatcacgg ctatcatatt cataaagagg aactgccgaa cgatgataaa ggggtgaagg 1475761 cataatgcaa gttcaagaaa aattcaccgc agaaaccttt ccagcttctc ctgaaaaagt 1475821 aaccctggaa gggaaaaata aatttttagg cttttggctt tttcttggcg gagagactgt 1475881 tctgtttgcg tctctcttcg ccacgtttct tgcgcttcgg aattcaaatg ccggtgatcc 1475941 gcctacgacg gaaatgttcg atgtgacact tgtattcatt gccacaatgc ttctattaac 1476001 gagcagttta acgagtgtgt acgcgatgta ccacatgaag aacttttcct tcggcaagat 1476061 gcagctttgg ctgggaatta cgattttatt gggggcgggc tttttaggac tggaaatcta 1476121 tgagttcaag cattacaccc atgaatttgg ctttaccatc acaagctctg cccttggttc 1476181 tgcgttttac acgcttgtcg gtacacacgg cgcccacgtg gcatttgggc ttatgtggat 1476241 cagcacgctt atgatccgca atgccaagag agggctgaat ctgtatacgg cgcctaagtt 1476301 ttacgttgcc agcctttatt ggcactttat tgatgtcgtg tgggtcttca tctttaccgt 1476361 tgtatattta atggggatgg tgggataaac atggtcgata aaaaaagcag agggcatatc 1476421 aatagcgacc ttgaatttaa gaaaaaaaag catgcccggg agatgaaata tcaagtcctg 1476481 tcttttggtt taatgatcgg tcttacgatt gttgcatttc tgactgtggc cacggacggt 1476541 gtcggcagct ggtttacgat tcctttcatt attttgctag ctgcaattca agtcattttt 1476601 cagctgtatt atttcatgca tatgaatcag aaagggcatg aggcgccggc actgtttttg 1476661 tattcagggg tgtttgtcgc gtttatcact gtgcttgcgt ttgtgacaat tatatggtgg 1476721 taatttgaac agccgccgga ggtgaagaaa tgaatcagtt ggagatattt gggtttcgcg 1476781 cgatgtggag cccttatctt ttttgtatcc tgttaggcat tacggcgctt tatctctatt 1476841 tttacaggcg aatgtcttca aagccgaatc gaataactgg taaagagatg gtgtgctttc 1476901 tgtcggcgat gctgttttta tatgcagccg agggaagccc ggttgatctg ctcggacata 1476961 ttatgttcag tgcgcatatg gtgcagatgg ccgtcctgta tttggttgtc ccgccgctgt 1477021 taatcgcggg gattcctgca tggctctggg aaaaaatcat tttcaggcct tcaatcaaac 1477081 cggttttttc cttttttacg acgcctttaa ttgctttgct tttgtttaac ggcatttttt 1477141 ctttatatca tgtaccgctt atatttgata ctgtcaaaac agatccgttt taccatacat 1477201 taatcacttg gcttatcttt gtgcttgcgt tcttcatgtg gtggccgctt gttcataagg 1477261 ttgagcgtct acggcagctc agcggcttga tgaagctggg ttatattatg gcggacggta 1477321 tgctgctcac acctgcttgc gccttgatca tgttcagcgg tgcaccgtta tacgccacct 1477381 atacagatcc ggctttatgg gctgaggcaa tgaggctttg cgtgccagcg gatatgatgg 1477441 ggcaggtccc attaacaggg ccagagatgt tgaatacact gcctttgtta gaggatcagc 1477501 agctcggagc agtcatgatg aaaatcattc aggaaattgt gtacggtact tttttggccg 1477561 ttattttttt ccaatgggtg aagaaagaaa gggaaaagga cgggcaggag gagccgccgt 1477621 atattcagca gacgatatca taaaaggtac agcgaaatat gctgtacctt ttcgttacat 1477681 ttgaactgtt tttaacatgt tggctatgtc ctgaatcagt gccttgcttt ttgtcacaac 1477741 ctgtacggga aactcttccg tttctccata ttctactcca tgagggtagt aatgctttcc 1477801 taggagaggg gacattaatt gaatcacggc gcgcccgctt ccgacatcgc cttctgccgc 1477861 aataccttgt atccgcaggt aaaacgtacc ctcaatcgtc gaaaacttct tgtcataggt 1477921 gactctctcg taatcccatt gacccgctct gataagacct ttgctttcca ttaagtcgtc 1477981 tagccagctg agctcagcct taaccccttc aagtccgctt tcagtaaact tcaacactga 1478041 cccctcctta taaaaattac ctttcctgac aatcatagta tgaaagcgtt aaactttcaa 1478101 tgaatcttct tcttttgaaa gtatgcaaaa attaaatttt gacgacaata gcactagact 1478161 aaaggaggtt aaacggatga caaaaataaa agatctgatg acagccgact tgcaatattg 1478221 cacggtatta gataatgtat atgaagctgc agtaaagatg aaggacgcaa atgtaggagc 1478281 gataccggta gttgatgagg acggggaaac attggtcggc atcgtaaccg accgcgatct 1478341 cgtattaaga ggaatcgcca tcaaaaaacc gaactcgcaa aaaatcactg acgcgatgac 1478401 tgaaaaacct gtcagtgtgg aggaagatgc ttcagtcgat gaggttcttc atttgatggc 1478461 atcgcatcag ctcagaagga taccagttac aaaaaataaa aaactgactg gaattgtcac 1478521 gcttggtgat ctttctttat ctgagcaaac gaatgaacgt gccggcagcg ccttatcgga 1478581 tatttccgaa ggggataata gagaagaagg cttttttcat taacacataa atctttgaca 1478641 tgttaaatag gctgtattgt aatgggatgt aaacaagaga ttgtgaatcg ccacgggggt 1478701 gatagattga aaaatatatt gagagcaatg gttatccttt tgattatctg cggaacctat 1478761 gttctgttta ttcaatatgg atctgttcct gaaaagaaat caaatgacag cgagcctcag 1478821 gtgtcgaatg aggaagcgca aagcggcaaa cgaatacata tgccgacttc agggttattg 1478881 tccttcatgg gcaagcacgc cgatgaagta acgaaaaagc ttggggaacc tgaacgtatt 1478941 gacccttcgg cttatgatta cgattggtgg gtatacaatc aaggtaagga tcaatatatc 1479001 caaatcgggg tattaaacaa taaagtggtc acattattcg cgtcgggtaa tgatattaac 1479061 gccaagcctt tcaaaattgg agaatcaact ggcgaagtat tcaagaccac ccaggtggca 1479121 ccatttgtga atgtagagta taaaggaaat tcctatcggt ttgaattttc tgaagaagat 1479181 atcaatacaa gaccgactgt aaaggtagga aagatgtatg tccagctgta tatggacaaa 1479241 tttgagggga agctatccag catcagggcg tttgatgcgc agacctttgt aaagcaaaga 1479301 ccttatgagg tagtgtaccg cggggaatta attaaaccga aagccgtttc agatgagaaa 1479361 tggaaaaaga tccaaacaac gagcgaaaag caaatccttg atttgacgaa tgtcatacgc 1479421 gttaaacatg gacttgcgaa gcttgagtgg gatcagccaa cggcggaagt ggcatttggg 1479481 catagtgagg atatgaagga aaataattat ttctcccatg tctctaaaaa atacggctcg 1479541 ctgaaagacc gcttagaaga agggcatgtt gattttcagc aagcgggaga aaatatcgca 1479601 tacaattatg tggacggtcc ggctgctgta gaaggctggc tgaatagcga aggccatcga 1479661 aaagcgcttc tgaattcaga ttatacgcat cttggtgtcg gagtagaccg gaaatattac 1479721 acccaaaact ttattaagcg atggtaatga aagccgcgga cgaatggttc ccggcttttt 1479781 ctatttccat acaagctggt ctgaatgaat gtgctgatag cttacagata aggccgtttc 1479841 ccatcccttc agtcaggctt tttcaccagt gtatagggat atcgctaaaa attcatttgg 1479901 gaatgaatat aggcgaacac aatgcccgac aaaacgatac attgtagtag gtaacgattt 1479961 tcggaggggg tgaggattgt ggcgaatcaa catgccaatc attcaatcaa tgactttaaa 1480021 caattcgtca aaaagcatcc caagctgata aaagaagtgc gcaaagaaca aagaagctgg 1480081 caggacgtat atgaaaattg ggtcctcttc ggggagagcg acccgatttg ggatccatat 1480141 cgggaaccgg aagaagcttc tgaagctgtg cctgaaacac cgcaaaaaaa tgattttgtc 1480201 tcgaaaatgg tgacagcggt gaaaaagatg gatgtcaatc aaatgaacga acaaatcaat 1480261 aaaatgagcc agtcgatctc atcgttgcaa agccttctta atacattttc cggaagcgga 1480321 cagaagcatt ctcagccagg ctctggacag catccttttt cttttcgaaa ggattaaaaa 1480381 aggggagctc atatgcgcaa agaggttcag gaatatattt tagcaaacga agaacggaaa 1480441 cgattcatca gagaacagcc gatatggtac cgcaggcttt caagaaaacc ggatgatctg 1480501 tcctcctttc agcttgaaat gatgaatttt tatgaaaaaa ccattccgca tcgggtgaat 1480561 cagtttacga acgggattca aatggcgcaa atgatgatgc aaatgtttca agcgatgcgg 1480621 acaaaagatt aaaaggcccc gaagaagggt cttttttcat gcggtcataa ggttttgttg 1480681 gcggctgcgg ttaagcattt tccaattggc tggtttcatg gtaaactaac aactggaggt 1480741 gcatgttatg tatgcgacga tggaatccgt gcggcttcaa agtgaagctc agcagcttgc 1480801 cgagatgatt ctgcagtcgg agacggctga gaactaccgc aattgttaca agcgtctcca 1480861 ggaagatgaa gaggcaggtc ggattattcg ttcttttatc aaaataaaag agcagtatga 1480921 ggatgtacag cgttttggca aatatcatcc tgactataga gaaatatccc ggaaaatgag 1480981 ggagatcaaa cgtgagctgg acctgaacga taaggtggct gacttcaaga gagctgaaaa 1481041 tgagctccag tccattcttg atgaggtcag cgttgagatt gggacagctg tttcggagca 1481101 tgtgaaagtt ccgactggga acccttattt tgacggtttg tcttcatgcg gaggcggctg 1481161 cggttcaggc ggaagctgcg gatgtaaagt gtcctgacga gactggccgt ctcgtctttt 1481221 acatataaga gaaaacaggc aggtgattgt attggagaat aggcgccagg gcatggttgt 1481281 gtatctgcac tccctaaagc agagcaaaat gctgaggaag ttcgggaatg tgcactatgt 1481341 atcaaaacga ttaaaatatg tcgtactgta ctgtgatatg gaccaaattg aaaaaacaat 1481401 ggacaagatt gcgtcttact catttgtgaa aaaagtggag ccttcttata aaccgttttt 1481461 aaaattggaa ttcgagtcaa agcttgataa ggcaaaagaa tacgattata aaatcggcat 1481521 atagctataa aaaaatcccc gcaggcatct gcggggtcct tctattcctt aatatgttaa 1481581 ggagaaggca aagggagagg agaaaccgga ggaagaactt atggggaaac gtaagtcttc 1481641 tccgcggttg gcaacaacat cctctagatg ctgttgctta tagtatggac aaggatcatg 1481701 ctgcctatac acctgtttat caagattagc gttcattgtt tggaagaatg ctttatgtta 1481761 agataggatt gatttttttc tatgtacata gcggcgtccg gccgaataaa gaaacaaaat 1481821 agcttttaga aaaagtggtg tggaacatga gagtaatttc tggatcaaaa aaaggccgtt 1481881 cactaaaggc tgtagccgga acatcaacaa gaccgacaac cgacaaagtg aaggaatcca 1481941 ttttcaatat gatcggccct tattttgacg ggggcagggg acttgactta ttcgcaggga 1482001 gcggaggtct tggaatcgaa gcgctttcac gcgggtttga gcattgtata ttcgttgacc 1482061 gtgattttaa agcgattcaa acggtaaaat ctaatttgaa aacgctggag cttacaaaac 1482121 atgcacaggt ataccgcaat gatgcggaac gtgctttgca cgctgctgct aaaagagaaa 1482181 ccggctttcg cggaattttt ctcgatccgc cgtataagga acaaaagctg aaagcacttt 1482241 taactttgat tgacgaatat caaatgctgg aagaagacgg ctttatcgtc gctgagcatg 1482301 acagagaggt cgagcttccc gaaaccgtag gagatcttgt gatgacaaga aaagaaacct 1482361 atgggttaac aggtgtagcg atttataaaa agagggggta gtgaggtggc gagtatagct 1482421 gtctgtcccg gcagttttga tcctgtgacc tacgggcatc tggacatcat caaacgcggg 1482481 gcgcatattt ttgaacaagt gtatgtatgt gtgctgaata attcttcaaa aaagcctttg 1482541 ttcagtgtgg aagaacggtg tgagcttctg agagaagtca caaaagacat tccgaacata 1482601 acagttgaaa catcgcaagg cctgttaatt gattatgcaa aaagaaaaaa tgcgaaagcg 1482661 attttaagag gcttgagagc tgtatctgat tttgaatacg agatgcaggg gacatcagta 1482721 aaccgggtgc ttgatgaatc tattgagacg ttttttatga tgacaaacaa tcaatattcg 1482781 tttctaagtt caagcatcgt aaaagaagtg gcaagataca acggctcggt atcagagttt 1482841 gtaccgccgg aagtagagtt ggcgcttcag caaaaattca gacaaggatg agggttttga 1482901 ctcatccttt ttttgttccg tttgtcagtc tgtaagaaaa aatgataatg tacgtaaaca 1482961 gcgcgcatag tgtgacagca ggtccgatct gcacaagcag attccagccg tttataaagg 1483021 cagttgacat gtcactgctg ttaagagatt taaatacata ctgatacgga tcatgccatg 1483081 ctgtgtaaag aggtttccat aaaagcatga cgaagacagc ggcataaacg ccctgcagca 1483141 aacgtgcgat aaagaatggt ttaaatctaa tgtcggtttc cgataaaata cctgccacct 1483201 gagcttgtac ggaaaagccg ctaaacccaa gaataaagct gacgataatg gctttttgca 1483261 gaagagaaac atctgtctcg ctgacaagct tgctgcctaa tgtaatttca aacatccctg 1483321 ataaaagcgg aatgtccaat tgagtcggaa gctgaaacaa agtcagtgct ccttttgtga 1483381 aaacagacaa aacatcagtc agctggacca ctgacaacag ccgattgaag acagaaaata 1483441 aaataataaa gccgcctacc ataagaagcg tttgaacaga agacgtcacg gcgtcgccta 1483501 aaattttacc taagggccgt ttttctgcaa gtctggcggt atgaagagcg tgtaaagcat 1483561 ctttgactga agggaaaggt atcgttttct ttcttctgag atgctgctct tccttgcggc 1483621 cataggagcg cattgttaaa ccgacggcaa gattccccaa atagtgtgca gaagctaata 1483681 aaatgcctag tgatgcgttt tgaaagaaac cgacggcaac agcgccgaaa ataaagagcg 1483741 ggtttgaaga attggtaaac gacgcgagcc gttctgcctc tactcttgaa atctgatttt 1483801 cctgccgcag acgggcagtg agttttgcgc ccgctgggtt tcctgatgcc attcccatag 1483861 caagaacgaa gccgccgaca cccggcacgc gaaagatcgg ccgcataaaa ggctcaagca 1483921 aaacaccgac aaaccgcaca atgccaaagc cgattaagag ttcggacaga ataaaaaatg 1483981 gcagcaatga cggaaacaca acctcccacc acatagacag cccggtttta gaggcttcga 1484041 atgaggcctg tggatgtgag atgacagtcg ctgttaaaaa aagaaaaaac gaggcaatca 1484101 aaagtgtatt aatcttcgac aagttcattc ttacctcccc gatgctaaaa atgcccaatg 1484161 acatgtatat catgataaaa taatgtatga tgtaaaacgg ccaagcagta cctgtcctct 1484221 tgattctttg tactaatata cgagcatagg ggttcagttt agaccataga attcggtata 1484281 cagggaattc aggcaggagg ttaacgcttt ggccaaacct aaaatcgggt tagcgttagg 1484341 atcgggaggg gccagagggc ttgctcatct cggtgtgctt tccagtttac ataagcacca 1484401 aattgaagtg gatatgattg caggaagcag catgggcgct ttggtgggca gtttttacgc 1484461 cgccggacat gacgtggcaa cgatgaaaaa agtagccaaa gcctttaaac gaaggcttta 1484521 tgctgattat acggtgccga aactcggttt tttaaaaggt gaccgcgtca gacagcttgt 1484581 gcatgcttat acattcggaa aaccgattga agagctccaa atcccgctgg gcattgttgc 1484641 gtgtgatcta cagacgggag aaaagattgt gttccgaaaa ggatcagtgt cagatgcagt 1484701 gagggccagc atcagcatcc cgggtatctt tattccgcag cggctggacg gacgccttct 1484761 tgtagacggc gcggtcgtcg atcgaattcc ggtttctgtt gtgaaagaca tgggagctga 1484821 tattatcatc gcttcggatg tttccagggt tcgaaaaact gaaacagcag tgcatatttt 1484881 tgatgtgatt atgcaaagta tggatatact gcaaaatgaa ttagtgcggc atcaaacaat 1484941 tgccgcagat atcatgattc gcccttccct tgaaacatac agctcaagct cgtttgccaa 1485001 tattgaagaa atgatatcgg caggcgaaga ggcgacaaac cgaatgatca gcaagataag 1485061 aaaagaaata gagaattggg agggctcata atttgctacg taaaaaacat tttagctgga 1485121 tgctcgtcat cctcatactg atcgccgttt tatcatttat aaaacttcca tactatatta 1485181 caaaaccggg agaagcgaca gagcttgctt cattgataaa agtggaggga ggctacccgg 1485241 aaaaaggaag tctgtcctta atgactgtta aagtgggacc ggctaatcca tttacatatg 1485301 tgtgggcaaa gatgcaccct tattatgaaa ttgttcctga tgagagcatt aaggaggaag 1485361 gcgaatcaga taaggagtat atgaaaagac agctccaaat gatgaaaagc tcgcaagaaa 1485421 atgcggttat agccgcctat caaaaggcag gaaaaaaagt cagctattcc tttaacggca 1485481 tatacgcaag ctcagttgta gaaaacatgc cggcaaaagg gaaaatagaa gtcggtgata 1485541 aaatcatcag cgcagacggc aaaaactatc agtctgctga aaagctgatt gattatatca 1485601 gcagcaaaaa agcgggagat aaagtcacgt taaagatcga aagagaagaa aaagaaaagc 1485661 gtgtcaccct tacgttaaaa caatttcctg atgagccgga tcgggcagga atcggagttt 1485721 cgctttatac agacagaaac gtgaaggtag agcctgatat tgattttgaa atcgaaaata 1485781 ttggcggccc gtcagcaggg ttaatgatgt cccttgaaat ctataatcag ctgacaaaac 1485841 cagacgaaac aaaaggctac gatattgcgg gaacaggtac gattgatgtt gacggaaaag 1485901 taggcccgat cggcggcatt gatcaaaaag tcgtcgccgc agacaaagcc ggaaaagaca 1485961 ttttcttcgc gccaaatcaa aacggcgcca gcaattccga ttataagaac gcagtaaaaa 1486021 cagcaaaaga tattgattca aatatgaaga ttgtgcctgt tgataccatg caggatgcga 1486081 ttgattattt gaataagctg aaagcgaaaa gcacctgatt ctcaggtgct ttttctatac 1486141 atttaaaaag tgttgttcat cttcgtcata tcgaatcggt gcatgtccgt attcctgtag 1486201 gtcaaactca gttctcagcg gctcttctat cggcaggctg taaatcctgc ttgcttttac 1486261 gtccagatcg agagctggat gggagaaaga ggacagtttg ctgacaagcg gaacagacag 1486321 tgcttttttc ttttcggata aataagcctg tccttttttc gtcatgccga gaagcctgat 1486381 atacggcgcc ttatcgttgt caagcagctt ttgcatatcc tgtttttttg ttctggttaa 1486441 aatgtgtgta ttcatccgct ggagccttgt ccacgtatag cgttttgttt tcagcagttc 1486501 cataaattcc tgataggagc tggattttct gatcgaacga ataattctgt gctctaaacc 1486561 ttcctccacc tcgtatactt gctgtaattc ccgtgccgtt acagttgaaa ggctgtattt 1486621 taagtaagaa aagtagcttt caggtgtatg ccacaatccg aaagatttgc ggtaagctgc 1486681 taattcacgt gcagatgcag cagggagaaa acgaaggcag gcttcgagat tctggccaat 1486741 catcgctttt ctaatgcttg tggcacttgc tatatggttt tcgccttcag ggagatcggc 1486801 atcatgatag tccgaagaga ttcgtgccgt agtataaggt ttcataggat atcccccggt 1486861 tagaatcgag gtcacatact ggtatcccaa aatgttattt ggttttgaca agtcaagtgc 1486921 actttcagta tgcaaaatgg agctgaaggc gatagccgcc gctgctgggt aactggcccc 1486981 ctttttaagt tcttctttaa ttcggtcatt caatatatgt ttatgctcat caataagctg 1487041 tgctgtttct aaaaaaggct tgatatcccc attttcactc ccgaaaaaca gcgcctcaca 1487101 ttcaagttcg ttcaggatgg aaacactgcc gcgtgcaaaa atgtctgctt tttgcacggc 1487161 ataaagataa ggcagctcaa tgacaagatc aactccgctt tgcagcgcca tttttgttcg 1487221 ggcccatttt gatacaacag cgggttcccc gcgctgtaaa aaatgtccgc tcatgaccgc 1487281 gacagccgtg tcacatccgg tttgcagctt tgctgtttgg gcatgataaa ggtgaccgtt 1487341 atgaaaggga ttatattcaa ccaccaatcc gacagctttc atattttttc cgcctttctt 1487401 gctatgttta aaaacgtatg gtacatttgc aaatgaaaac tcttacgcct tatttttgtt 1487461 ttaagtgtat gcatagcata ttccgctgtc aacgatactt caatggcagc attatgctgt 1487521 aaagaaaaaa tattgacaaa aacaatctta aaagctataa tcatgtttgt tgctttcctg 1487581 aggtgataca aatgaaatgg acgatttatc agctgcatca aatgccaaaa caaagttttg 1487641 agtttgatga aacagttgag ttaaatgagc tgacaaagct gaattctgac attcgccgca 1487701 tttctcccgt tcgggtgaag ggcagagcgg atatcaaatc caaacaggtt tcgtttgatt 1487761 ttacaatttc aggcgaaatg cttttgccat gctcaagaac actcgttgat gttccgtatc 1487821 catttgaaat ttcaacaaaa gaactgttta tatttcatca cacggatgat atagaagatg 1487881 atgacgttca cattgttgag gacgatacta tcgacataac tccgatcgtg aaagaagaaa 1487941 ttcttttaga aatccctatg caaatctttt gtgaatctga acaagaaaaa ggagctgctc 1488001 ctcaagaagg aaaggattgg caagtcattt cggaagaaga caagaagaat caagttgatc 1488061 cgagacttgc agcccttgaa aagctcttaa aacaagatga tgaatcttaa ctctttaagg 1488121 aggtgggaat aatggctgta ccttttagaa gaacttctaa aatgaagaaa agattgcgcc 1488181 gtacacattt caaacttaat gtacctggta tgacagaatg tccgtcatgc ggagagatga 1488241 agttgtctca ccgtgtatgc aaagcatgcg gatcatacaa cggcaaagac ataaatgtaa 1488301 aaagtaacta atgagaaaag cgcagggtga aagccctgcg ctttttcttt ttctcttcct 1488361 gtcagcttgc ggaaaatttg tgagtgcaaa tagtctatct aatctattac cggcatatgt 1488421 atgagataaa taagctgaca tggagggaga ttgaatttga ccattacaag acaagatgct 1488481 tggactcagg atgaggattt gctgctggca gaagtggtgc ttcgtcatat tcgagaggga 1488541 ggaacacagc tttcagcctt tgaggaggtt ggaagggcgc tgaccagaac cgcggcagcc 1488601 tgtggtttca ggtggaactc gtatgtgaga aaacaatacc agtcaggtat agagcttgca 1488661 aaaaagcaaa ggaaagaact gagaaagcaa atcggcgttc attcggtcaa tatgccgaat 1488721 tccatgaagc agactgcctc ggcatcgtca gaaggaaaac gagatttgtc cattcaggat 1488781 gtcattcaat ttctcgaaca attcaaagaa acaccgtctg cacaagaatt tcagcttgaa 1488841 agggaaaaat tgaaggagca aatccaatcg ctgcaaaaag agcttgagga tttgcggagt 1488901 gaaaatcaga cattgcggaa tcagctagag atgacagaag aggattacaa ggcactgatc 1488961 gatatcatgg atcgggccag aaaaatggtt gtttcgaagg aagacggaag aatgaaaaaa 1489021 gcggctcaag aaacgtaaag aaacgcctga aatgaaccgg ccctatagta agaataggcc 1489081 ggttgttttg atttctatgc agactctccc ggtgtcattt cgcgatccat atcaggatgc 1489141 cagatgagcg ggttttcccc tttgtcccgc gccatatcat acttaacagt tttaaagttc 1489201 attttgttcc aaaattccgc tgatttcatt ctcggatttg tccggatcgg cattttgaat 1489261 gattttgcaa attcaaccaa ggctctcccg tatcccctgt tctggtagcc cggaagaacc 1489321 tcaagcttcc acagctccaa ataatcctgg cggttgtcaa aatagggatt cgatttgccg 1489381 ttaacttgat acagactcat tcgtgctaca agtttatcgc caaaataaat cccgtaaaaa 1489441 ggcgaggtgc tgtcattttc aataatatta tcctgaagtt cttcaagcat tgaaagctcc 1489501 tgaatgccgt attctttgaa tttcttgaat tcttccagcg ttttatagtt gataagcaga 1489561 cgttctacct ttgtcaaaca aatctccccc tttgttgttt ctacatatat tgtaaacgct 1489621 ttatttaaaa aatccaaata tttaaacttt aattttaagc acatgggatc tttgagaagt 1489681 aatttcttct tacttctgct atgataatac gtaaatgcta aattgggtgt gacatcatga 1489741 aaattggaat tatcggcgga ggctccgttg gtcttttatg cgcctattat ttgtcacttt 1489801 atcacgacgt gactgttgtg acgaggcggc aagaacaggc tgcggccatt cagtctgaag 1489861 gaatccggct ttataaaggc ggggaggaat tcagggctga ttgcagtgcg gacacgagta 1489921 tcaattcgga ctttgacctg cttgtcgtga cagtgaagca gcatcagctt caatctgttt 1489981 tttcgtcgct tgaacgaatc gggaagacga atatattatt tttgcaaaac ggcatggggc 1490041 atatccacga cctaaaagac tggcacgttg gccattccat ttatgttgga atcgttgagc 1490101 acggagctgt aagaaaatcg gatacagctg ttgatcatac aggcctaggt gcgataaaat 1490161 ggagcgcgtt cgacgatgct gaaccagacc ggctgaacat cttgtttcag cataaccatt 1490221 cggattttcc gatttattat gagacggatt ggtaccgtct gctgacgggc aagctgattg 1490281 taaatgcgtg tattaatcct ttaactgcgt tattgcaagt gaaaaatgga gaactgctga 1490341 caacgccagc ttatctggct tttatgaagc tggtatttca ggaggcatgc cgcattttaa 1490401 aacttgaaaa tgaagaaaag gcttgggagc gggttcaggc cgtttgtggg caaacgaaag 1490461 agaatcgttc atcaatgctg gttgacgtca ttggaggccg gcagacggaa gctgacgcca 1490521 ttatcggata cttattgaag gaagcaagtc ttcaaggtct tgatgccgtc cacctagagt 1490581 ttttatatgg cagcatcaaa gcattggagc gaaatacaaa caaagtcttt tgagcttttt 1490641 cggtaacatg ctatactcat ttcggatcac taactattta ttggagaaag gaagttctag 1490701 aagatgcagc taactgaact ttccatcaaa aatcagaatg tgtttgtaca gcactatata 1490761 gatggcaaag aagaaatgtc ttcttttttt gattacagta ttcatcataa ggacatgtgg 1490821 cgcgaaagac tggaagactt atcttcccgg tttttcgcaa gagaggaatt ggcggcgtac 1490881 ttaacctctt accataataa attcggttca agtgcgatgc agtctgctat tgagaagctg 1490941 aaggacccgt caagtgccgc tgtagtcggc ggacagcagg caggactttt aacaggaccg 1491001 ctttacacca tacataaaat catttcaatc attgttttag caaagcaaca agaaaaggaa 1491061 ctgcaagtgc ctgtcatacc aatcttctgg gtggctggag aagaccacga tttggatgag 1491121 attaattttg ttcacacatc tgaagagaat gggcctgtga aaaaaaagct gcctcagtct 1491181 tattggaaga aatcatcagc agcgagtaca tcgcttgatc aggaaaagtg tgccgcgtgg 1491241 atagatgatg tttttgccgc ttttgaagaa acagaccata cgaatacact tctcgacaat 1491301 gtgaaacgat gtttaaggga atctgttacg tttactgact tctttgaact gctgatcgcg 1491361 gatttgttcc aagaagaggg cttagtttta ttaaattctg gggatccggg gattaaaaag 1491421 ctggaaacgg ccatgttcca aaagattctt cgagaaaatg atgaactcgc ccgggctgta 1491481 tcagatcagc aggccttcat gcgtcaagca ggctacaaac cgattatcga gtccggaaaa 1491541 gagcaggcga atctgtttta tgaatacgaa gatgagcgtt ttttaattga aaaagataac 1491601 ggccgatttg tcatcaaaga gcttgatcta ggatggacga gggatgaact tcatacacat 1491661 atggaagaac atccagagcg tttcagcaac aatgttgtaa cgagaccgtt aatgcaggaa 1491721 tttctcattc cgactttagc atttattgca gggcctgggg aaatcaatta ttggggcgag 1491781 ctcaaacagg catttgcggt gatgggcttc aaaatgcctc ctgtcatgcc aaggctgaac 1491841 attacgatac ttgagcggca tattgagaaa aaactggctg aacggaatat ctcattacaa 1491901 gacgcgattg agcgcggaac ggagaatcaa agagagacat acttcgagcg ccagattccg 1491961 gaagagttta cggcggtgat ggatcaggcg aaaagccaaa ttgaagcgat tcacaaaacg 1492021 gtccggcagg aggcgttaaa ggttgatcaa agcttggaac ctttacttct gaaaaatgcc 1492081 gcttttattc aggatcagct tcaattctta gagcgcacgg tgatgaagcg aattgaagaa 1492141 aaagaaggct acgtcttgaa ggattatgaa agaattcaaa atagcattaa gccgcttctt 1492201 gcgccgcaag aacggatttg gaatatcatg tattatttga acaggtacgg tccaaaattc 1492261 ttcacgacat tcaagaatct gccattttct tttcaaaatc aacatcaagt tgtcaaactt 1492321 tgaaataaag ttttaaagaa ccctgactag ttcagggttt ttttttatgg gtaaacagtg 1492381 taaaatgaag ttgtggagcg aagtggtgaa tagtggtgag ttaaggagag aaagtggggc 1492441 aagagatcat gtttatgggt gaatatcagc ataccatcga tgcgaaaggc cgcatgatcg 1492501 tacccgctaa attcagagaa ggcctaggtg agcaatttgt gctgactaga ggacttgacc 1492561 aatgtctctt cggctaccct atgcacgaat ggaaacaaat tgaagaaaaa ctaaaagctc 1492621 ttcctctcac aaagaaagat gcccgcgcgt ttacccgttt cttcttttca ggggcgactg 1492681 aatgcgaact ggataagcaa ggcagggtaa atatcgcatc atctctattg aattacgcca 1492741 aactggaaaa agaatgtgtt gttatcgggg tttctaatcg aattgaattg tggagtaaag 1492801 taatttggga acaatacaca gaagagcaag aagattcatt tgctgaaatt gctgaaaaca 1492861 tgattgggtt tgatatataa tgattcttcg tgtataacac tctaaaaaca atttcaattc 1492921 atcctgataa aaggtgggac caacacaata tgtttcaaca caagacagta cttcttcgtg 1492981 aaaccgtaga cggacttaat attaaaccag acggtacata tgtagactgc acactcggcg 1493041 gagctgggca tagtacatac ttattgcagc agttatccga gaaggggcgt ttaatcgctt 1493101 ttgaccaaga tgatacggca ttacagcatg ctaaagaagt gttgtccgat tataaaggac 1493161 agctcattct gattaaaagc aatttcaggt atttaaaaga atatttgaat gaacaaggcg 1493221 ttacagaagt agacggcatt ttatttgatt taggggtgtc ctctccgcag ctggatacac 1493281 cggagcgcgg attcagttac catcatgacg caccgttgga catgaggatg gaccagtcgg 1493341 ctacgctttc ggcgaaagaa gtcgttaatg agtggcgcta tgaggatctc gtccgtattt 1493401 tctttaaata cggagaagag aagttcagta aacagatcgc cagaaaaatt gaggaggcaa 1493461 gaatgaagtc tcctattcaa actacgggcc aactggtcga tctaataaaa gacgcgattc 1493521 ccgctccagc gagaaggagc gggggacatc ccgctaaacg cgtgtttcag gcaatcagaa 1493581 ttgccgtaaa cgatgaactt agggtgtttg aagaagcttt ggagcaggca attgaggttc 1493641 tgaagccagg gggcagggta tcggtcatta ccttccactc gctagaagac agaatttgca 1493701 aaaccacttt taaagaaaag tcgtcgcttc cggaacttcc tccgggactt cctgttatac 1493761 cggaagagtt tgaaccggag ctgaagctca tcacacgaaa accgattacg gcatctcaag 1493821 aagagcttga agagaacaac cgggctcgtt ctgccaagct tcggattgct gaaaaaagaa 1493881 aataacgaaa cgcgaacgca aaattaaaag gaggtcatca gcctatgagc aatttagctt 1493941 accaaccaga gaaacagcag cggcatgcga tcagtcctga gaaaaaagtg attgtcaaga 1494001 aaagggcttc cattactctc ggagaaaaag tgcttcttgt cctctttgct gcggcggtgc 1494061 tcagcgtatc gcttttgatc gtatcgaagg cgtatgcggc atatcaaacc aatattgagg 1494121 tgcaaaagct tgaggagcaa atttcatccg aaaataagca aattggtgac ctcgaaaaaa 1494181 gcgttgctga tttaagcaaa ccgcagcgca ttatggacat tgcgaaaaag aacggcttga 1494241 atttaaaaga taaaaaagtg aaaaacatac aggaatgatt caaatgccaa aaaagaataa 1494301 atttatgaat agaggagcag cgattctaag tatttgtttc gctctctttt tctttgtcat 1494361 cctggggaga atggcatata ttcaaataac cggaaaagcg aacggcgaag tgcttgcgac 1494421 aaaagcgaca gagcagcatg aaaagaaacg gaccatcgaa gcgagccgcg gctcgatttt 1494481 agaccgaaaa ggaaaagtca ttgcagagga cacagcgacg tataaactga ttgcgattct 1494541 cgataaaaaa atgaccactg atgtcaagca tcctcagcat gttgtaaaca aagaaaaaac 1494601 ggcggaagca ttgtctaaag tgataaactt ggacaaggcc gacatccttg atatcttaaa 1494661 taaagatgca aaacaagtcg agtttggctc agctggccgg gatattacgt attcacaaaa 1494721 gcaaaaaatc gaaaaaatga aactcccggg catttcattt ttacgggata caaaacgcta 1494781 ctatccaaac ggagtatttg catctaatct aatcggctat gccgaggttg atgaagaaac 1494841 aaatgaaatt tccggcgcga tgggattaga aaaagtgctg gataagtatt tgaaggagcg 1494901 ggacggatat gtgacatatg aaagcgacaa atccggctgg gagctcccga acagcaaaaa 1494961 taaaattaca gcgccaaaaa atggtgacaa tgtatattta accattgacc agaaaattca 1495021 aacctttttg gaagacagca tgacaaaagt ggcgcaaaag tataatccga aaaaaatcat 1495081 ggccgcagtc gttgatccga aaacgggcaa agtccttgcc atgggacagc gcccaagctt 1495141 tgatccgaac aagcgcgatg tgacaaacta ctataatgat ttgatttcat atgcgtatga 1495201 acccgggtcc acgatgaaga tctttacact cgctgctgcg atgcaggaaa acgtgtttaa 1495261 tgcgaacgaa aaatataaat cagggacatt tgaagttggc ggagcacctg ttaaggatca 1495321 caataacggt gtaggctggg gtccgacaac atatcatgac ggcgtcctaa ggtcgtcgaa 1495381 tgtcgctttt gcgaaactgg cgaaagaaaa gctgggatat gaccgcctca atcaatattt 1495441 gcacaaattc aatttttacc agaaaacagg tattgatttg ccaggagaag tctccagcaa 1495501 aatcaacttt aaatatgaat ttgataaggc gtcaactgca tatggccaag cgtctgcggt 1495561 cacaccaatt cagcagattc aggccgcaac ggcaattgca aatgacggta aaatgatgaa 1495621 accttatgtc attgaccata tcgttgaccc tgataaagat aaaactattt atcaaaataa 1495681 gccggaatca gccggaactc caatttctgc aagtactgcg aaaaaggtgc gggatatatt 1495741 aggagaagtc gttacatcga agatcggaac agggcaagct tataaaatcg aaggttttga 1495801 tgttgccggg aaaacaggta ctgcgcaaat agccggtaaa ggcggatatt tagacggcac 1495861 agataactat atcttttcgt ttatgggtat ggcgccaaaa gatgatcctg agcttttaat 1495921 ttatgttgct gtacagcagc cgcaactaaa agcaggacaa agcagttcag atccagtatc 1495981 agaaatcttc aatccaacaa tgaaaaatag cctgcactac ctaaacatcg aaccaactga 1496041 aaaatctgac tcagataagg aagaaacaaa agcgcagaca atgcctgatt taacagatca 1496101 aacggtagct gctgctcaaa agaaagcaaa agaggagaat ctcacaccaa ttgtcatcgg 1496161 cagtgatgtc gctgtaaaag aacagtatcc gaaagcggat gaggaagttc tcaccaatca 1496221 aaaggtcttc ctgaaaacgg gcggcaaaat caaaatgcct gatatgacag gctggtcgag 1496281 aagagaggtt ctgcagtacg gcgagctcgc gggaattcat attgaagtaa gcggacaagg 1496341 ctacgctgtc agccaaagtg ttaagaaaga caaagaaatc aaagacaaaa ccgtaatcaa 1496401 ggttaagttt aaaaatcctg attaaaaaga aagccgtcgt tatgcaggct ttcttttttt 1496461 atgccttcag aggagcatcg ttctacctgt ccaaattcag gcataaaatg aaacaagcct 1496521 aaataaggag tgaacggtct cttgcgcgtc tcgaatgtaa cggttagaaa acgtttatta 1496581 tttgttttgc tttttggcgt gatcgtgttt ctgatcattg atacaaggct ggggtatgtt 1496641 cagtttgtga tgggcgaaaa actgacttcg ctagcgaaag attcctggag ccggaacttg 1496701 ccgtttgagc cggagagagg cgagattctg gatcggaatg gtgtgaagct cgcaacaaat 1496761 aaaagtgcgc cgaccgtatt cgtcgtgccg cgccaagttc agaatccgat gaaaacgagc 1496821 aagcagcttg cggcggtgct caatatgtca gaagaaaaag tatataaaca tgtgacaaaa 1496881 aaagcgtcaa tcgaaaagat cactcctgaa gggagaaaaa tttcaaatga gaaggcgaaa 1496941 gaaatcaaag cgcttgattt aaaaggtgtg tatgttgcgg aggacagtat ccgtcattac 1497001 ccgttcggca gctttttatc tcatgtgctt ggatttgcag gaattgacaa ccaagggctc 1497061 cttggacttg aagcctatta cgacgatgat ttaaaagggg aaaaaggttc tgttaagttt 1497121 tatacagatg ccaaggggaa gaagatgcct gatgaagcgg atgactatac gccgcctaag 1497181 gatgggcttg atatgaagct gacagttgat tcaaaggttc agacgataat ggaaagagag 1497241 cttgataacg ctgaggccaa atatcatccg gacggcatga ttgccgtagc catgaatccg 1497301 aaaaacggag aaattttggg gatgtctagc aggcctgact tcgaccctgc tgattaccaa 1497361 tctgttgatc cgtccgtcta caatcgaaat ctgccagtat ggagcacgta tgaaccggga 1497421 tctaccttta aaattattac acttgcagca gcccttgaag agcaaaaagt aaatttgaaa 1497481 cgggatcaat tttatgataa agggcatgct gaagtggacg gagcgagact gcggtgctgg 1497541 aaaagaggcg ggcacgggct gcagacgtat ctggaagttg tgcagaactc ctgcaacccg 1497601 gggtttgttg aattaggcga gcgcttagga aaggaaaagc ttttcaaata tatcaaagac 1497661 tttggttttg gacaaaaaac ggggattgat ctccaaggcg agggaacagg catcttattc 1497721 ccgcttgaga gagtgggccc ggtggagcaa gcaactacgg ctttcggaca gggagtatcc 1497781 gtcacgccga ttcagcaggt tgcagcagta tccgccgctg taaacggagg aacgctctat 1497841 acaccttata ttgcaaagga atggatcgat cctgttacga agaaaacggt caaaaaacaa 1497901 tcaccaatcg caaagaaaca agtcatttct gaggaaacat ccaaacaaat ccgctatgct 1497961 ctagaaagcg tcgtcgcaga aggaaccggc cgcaatgcat ttgtagaagg atatcgtgtc 1498021 ggaggaaaaa cgggaactgc acaaaaggtt aaagatggaa aatatcttga aaacaaccat 1498081 attgtatcat ttatcggttt cgcgccagca gatgatccga gtctagtcgt ctacgttgcg 1498141 gtggataacc cgaaaggcac gattcagttt ggcggaacgg tggcagcgcc tattgtcgga 1498201 aatattatga gagacagtct gccggaactt ggtgtgaagc cccggaaaaa tcaaatcgag 1498261 aaaaaatacc aatggaacga cacaaaaaca atagaagttc cgaatgttgt agggatgtct 1498321 gtctcagatc ttgagtcact attggtgaat ctcaatgtgg atgcttccgg gaaagggagc 1498381 aaaatcgtta aacaatcgcc agctgccgga acgaaagtaa aagaaggctc aaagatacgc 1498441 gtgtatttga ctgaagaaga tgaaaaggag gcagccgatt gattcgggct gcctattctt 1498501 ttattgcaga aaaaatgctg atatctttca agattagctg gatgtatcct tttatttacg 1498561 ctaaaatatg aactgtatgc ttaaaatcat taccacatca tttgatgtga cttcaatgat 1498621 aaaaagaacg aattagaatg ttgagaggtt tgatacgatg aaacttacaa agctgcttac 1498681 atacttaaca accgaacctt ctgtaaacga ctcacaagac cctgaaataa cttcaattga 1498741 gatggactcc agggaagtaa agaaagggag tctttttgta tgtgtaaaag ggtatacggt 1498801 ggatggccac gattttgcgc aaaaagcagt agaaaacggt gcagcggcta ttgtggcaga 1498861 aagagaggtc gatgtgaatg ttcctgttat tattgtccgg cagtcacttc gcgcgctcag 1498921 cgttttgtct gatgcgtttt acggacagcc gacgaagaag cttcagctga ttgggataac 1498981 agggacaaac ggcaaaacat caacgaccca catggtcgat gagattctga aaaaagcggg 1499041 aaaacgcaca ggcttgatcg gtacaatgta catgaaaatc ggagacgaaa cacttcctgt 1499101 taaaaacacg actccggaaa gcgtcacgct gcagaaaacg tttaagaaaa tgaatgacaa 1499161 gcacgttgac actgcaatca tggaggtttc ttcccacgct ttgtctttag gacgcgtcca 1499221 tggctgtgat tatgatattg ccgtgtttac gaatttaaca caggaccatc tggactatca 1499281 taaaacgatg gatgagtacc ggcatgcaaa aagcttgctc ttttcccaac ttggcggggc 1499341 tttcaaccat gaacatccaa agcgtgccgt cctgaatgct gacgatgagg cgagcgctta 1499401 ttttgaaaag gtaacagctg cgcatatctc tacatacgga attaaaaacg atgctgatgt 1499461 gatggcgaag aacatcagta tcactgcaca gggcacaagc tttgatctcg tgacaaacaa 1499521 aggcacgaag cacatcacga tgtctctcgt cggacaattt aatgtgtata acgtgctggc 1499581 cgctgttgcg acatgtattg cagcaggcat accgtttgaa atcatcactg aggctgttga 1499641 agaattgcat ggtgtaagag gccgttttga attggtcaat cagcagcagg agtttcctgt 1499701 cattgtagac tacgcgcaca caccggacag ccttgaaaat gtgctggaga catgcagaga 1499761 catgacggaa ggaaagctat ttgtcgttgt cggctgcgga ggagacagag ataagacgaa 1499821 gcgcccgaaa atggctaaaa ttgctgtgga gctggctgac gagccgattt tcacgtcaga 1499881 taacccgaga agcgaagatc ctcgcgcgat tttaagagat atggaagccg gagtagagaa 1499941 cgcatactat cacagtattg caaaccgcga gcaggcgatc tttttcgcaa ttgccaatgc 1500001 caaaaaaggc gacgttgtcc tcattgccgg aaaaggacat gaaacctatc agcagatcgg 1500061 aaatgaaact ttcgattttg atgatgctga agtagcggcg agagccattg ttgaactcaa 1500121 taagaataag acgaattcat aggaaagaga tgttactgaa taatggagct tgaaaagatt 1500181 tttcatatgg aaaaaaatca tgaatatgat aactacgtat gtcgtttgaa agaaacagga 1500241 ggagaaaagg acaatgcttg agcaagtcat tctgtttaca attttaatgg ggtttttaat 1500301 tagtgttctg ctctctccga ttcttattcc gtttttaaga agattaaaat tcggccagag 1500361 tattagagaa gaaggaccga aatcacatca gaaaaaatca gggacaccga caatgggcgg 1500421 ggtcatgatc atactttcta tcatagtgac aacaattgtt atgacacaga agttttcaga 1500481 aataagcccc gaaatggtgc tgcttctgtt tgttacgcta ggctacggtt tgcttggctt 1500541 tttagatgat tacatcaagg ttgtcatgaa gcgcaatctt ggattgacat caaagcaaaa 1500601 gctgatcgga caaattatta ttgcggttgt attttacgcc gtgtatcatt actacaattt 1500661 tgcgacggat attcgcattc ctggaactga cttatcattt gatcttggct gggcttactt 1500721 tatccttgtg ctctttatgc tagtcggcgg atcaaacgca gttaacctga ctgacggcct 1500781 tgacgggtta ttatccggta ctgcggcgat tgcctttggc gcctttgcca ttctggcatg 1500841 gaatcagtct caatatgacg tagcgatttt ctcagttgcc gttgtcggtg cagttctggg 1500901 cttccttgta tttaatgctc atccggccaa agtttttatg ggagatacgg gatcgcttgc 1500961 attgggagga gccatcgtta ccattgccat tttaacgaaa ttagagatcc tgctggttat 1501021 catcggcggt gtattcgtta tcgagacatt atccgttatt ttgcaggtca tcagctttaa 1501081 aacgacaggt aaacgaatct ttaaaatgag tccgcttcat caccattatg agcttgtcgg 1501141 ctggtctgaa tggagagtag tcgtgacgtt ttgggctgcg ggacttttgc ttgccgtttt 1501201 aggaatttac atcgaggtgt ggttataagt ggaaaatgat caatttttac agaaacagca 1501261 ttttttaatc cttgggcttg cgaaaagcgg atatgcggcg gcctccattc ttcatgaaaa 1501321 aggcatttat gttgcagtca atgatcaaaa gccttttgaa gaaaatgaac cggcacaaaa 1501381 gctttctgaa aaaggaatcg aagttgtttg cggagagcat ccagtttctc tgttcgatca 1501441 gcatcaaatc acgattctga tcaaaaaccc gggaattcct tatgaaaata tcatggttca 1501501 ggaagcagag aaacgaggta ttccggtttg gacggaaatt gagctcgctt actacctgac 1501561 cagcgccaag tttatcggga ttaccggatc gaacggtaaa acgaccacga caacgctaat 1501621 ttacgaaatg ctcaaggctg actcgcaaaa agcactgatt gccggaaaca tcggcacagt 1501681 cgcaagtgag gttgcctatc atgctgatgg agatgaatgg atcgttaccg aactgtcttc 1501741 gtttcagctg atgggaacac acgctttcag accggaaatc agcctgattt taaatgtatt 1501801 tgacgcccat ctggattatc accatacgcg cgaaaactat gaaaaagcga aacagaaagt 1501861 gtaccttcat cagactgctt cagataaagc tattgtcaac caggatgatg aaaccgtcgt 1501921 gcgtcttgct gaagccggaa aagccgaaat cgtcccattt tcagtcagca aaacgcttga 1501981 acagggcgca tatgtaaaag acagtatgat tatgtttaac ggcgaagcca ttcttcctct 1502041 ggaagaggtt gtactgcccg gtgctcataa cctggagaac attttagcag ctattgcagt 1502101 tgtgaaaacg gcaggagcat ccaatgaggc ggttaaaaag gtgctgacaa gctttactgg 1502161 tgtgaagcac cgcctccaat atgtcacaac tgtgaatggc cgcaaatttt ataacgacag 1502221 taaagcaaca aacattctgg cgacaagcaa ggcgctttca gcttttgata agccggtcat 1502281 tctgcttgcg ggcggactgg atcgcggaaa tggttttgat gacttgaaac cttatatgaa 1502341 gcatgtcaaa gcagtgctta catttggcca gacggcgcca aaactcgaga aactcggcaa 1502401 tgaactggga atacaacatg tcaaacgtgt cgataatgtt gaacaagcag tatctgcggc 1502461 gtttgcgctc tcaaatgaag gagatgtcat cctgctgtca cccgcgtgtg cgagctggga 1502521 tcaattcaaa acatttgaag aacgcggtga catgtttata gatgccgtgc atatgcttaa 1502581 gtaagggctt gtcttgaagt aaatcggcag ccctaatgac tttaagcttg gggtgtcgat 1502641 tgctttgact actaaaaaaa catcgcctga tttgttattg gtcatcatta cgttattatt 1502701 attaacaatc ggattaatta tggtgtacag tgcgagtgcg gtatgggcgg attataaatt 1502761 tgacgactca ttctttttcg cgaaacggca gcttttgttt gcgggaatcg gcgtcattgc 1502821 tatgtttttt atcatgaatg ttgattattg gacttggagg acatggtcca aattgctgat 1502881 ggttatctgc tttttccttc tggtgcttgt tttgataccg ggcgtcggaa tggtgcggaa 1502941 cggttcaaga agctggatcg gagtcggagc attcagcata cagccttcag agtttatgaa 1503001 gcttgcgatg attgcattcc ttgctaaatt tctctctgaa aaacaaaaaa acatcacatc 1503061 gttcagacgg gggttcgtcc ctgcacttgg catcgtgttt tcagcatttt tgattatcat 1503121 gtgccagcct gacctcggaa cggggacagt tatggtcgga acttgtattg tcatgatttt 1503181 tgtagccggc gcacggatcg cccatttcgt ctttctcggg ctgatcggcc tcagcggatt 1503241 tgtcgggctc gtactatcgg ctccatatcg gataaagcgg attacctcat acttaaatcc 1503301 atgggaagac ccgctcggaa gcggatttca gatcattcaa tcgctttatg cagtggggcc 1503361 cggcgggttg ttcggaatgg ggctcggaca aagcagacag aagttctttt atctgcctga 1503421 gccgcaaaca gactttattt tcgccatctt gtcagaggag ctgggcttta tcgggggaac 1503481 acttattttg ctcctcttca gcgtcctgct gtggagagga atcagaattg cgcttggtgc 1503541 gcctgatctg tacggaagct ttgtcgcagt cggcattatt tcaatgattg ccattcaagt 1503601 catgataaat atcggcgtag tcacgggcct gattcctgta acaggcatca cgctcccgtt 1503661 tctgagctac ggaggctctt cattgactct aatgctgatg gcagttggtg tgctgctgaa 1503721 tgtaagccgc tactcgaggt attaacgaat gtatttccaa gcctcctgtc taacatgaag 1503781 cttggaaaca attgatgcga taaccctgtc caacaaaaca gggttatcgt tatgttatag 1503841 agaaacttag actgggggaa aaaagaaatg cgaattgcaa taagcggagg cggtacaggg 1503901 ggacatattt atcctgctct tgcttttatt aaagaagtgc aaagacgtca tcctaatgtg 1503961 gaatttttat atatcggaac agaaaacggg ctggagaaaa aaattgttga gcgggagaat 1504021 ataccgtttc gttcaattga aattacagga tttaaaagaa aattgtcatt tgaaaatgtc 1504081 aagactgtga tgcgttttct gaagggcgtc aaaaagagta aatcgtattt agcggaattt 1504141 aagcccgatg ccgtaattgg aacgggcggt tatgtatgtg ggccggttgt ctatgccgct 1504201 gcgaaaatgg gaattccgac tattgtccac gaacaaaaca gcctgccggg catcacgaat 1504261 aagtttcttt caaaatatgt taataaagta gcgatttgtt ttgaagaagc gaaatcacat 1504321 tttcctagcg agaaagttgt atttacggga aacccgagag cctctgaagt cgtctcaata 1504381 aagacgggac gatcattggc tgaatttggg ctttctgaag acaaaaaaac ggtcttaatt 1504441 ttcggcggaa gccgaggcgc tgcaccgatt aaccgcgctg tcattgacat gcaggatgtg 1504501 ctgaaaacaa gagactatca agtgctgtat atcaccggtg aagttcacta tgaaaaagta 1504561 atgaatgagc tgaaaagcaa gggtgccgct gataatatgg tcacaaagcc gtttcttcat 1504621 caaatgcctg agtatttaaa ggccattgat gtcattgtgg ccagagccgg tgcgacaacg 1504681 attgccgaaa ttactgctct cggaatccca agtgttctga tcccaagtcc atatgtgaca 1504741 gcgaatcacc aggaggtcaa tgcgaggtct cttggccagc atgatgcggc gattgtactg 1504801 aaagaaacag agctcagcgg ggagaagctg attgaagcgc tagaccggat tgtactgaat 1504861 gagcaaacgt taaaggaaat gagcgaacga acaaagtcac tcggtgttcc tgacgcggct 1504921 gcccgtttat acagcgtact cgaggaatta aaaaaatagt agaaaagcaa atggaatgcg 1504981 gaggtttacg atggagaaag tgatacagga attaaaagaa cgagaagtcg gcaaggttct 1505041 tgcaaatgaa ccgctcgcga atcatacaac gatgaaaatc ggcggacctg cggatgtatt 1505101 ggtcattcca agcagtgtgg atgctgttaa agacatcatg gacgtgatta aaaaatatga 1505161 tgtgaagtgg acagtcatcg gccgcggatc aaatcttctt gttttagatg aaggaattag 1505221 aggcgtagtg atcaagctgg gggcgggtct tgaccatttg gagcttgaag gggaacaagt 1505281 aacagtcgga ggcggttatt cggtggtccg ccttgctaca tcattgagca aaaaaggcct 1505341 gtccggtttg gaatttgctg ccggcattcc aggatcagtc ggcggagcgg tttatatgaa 1505401 tgccggcgct cacggttctg atatgagcga gatcctcgtc aaagcgcata ttttatttga 1505461 agacggaacg attgagtggc tgacaaatga gcagatggat ttcagctaca ggacatctgt 1505521 actgcaaaag aaacgcccgg gcgtttgcct tgaagctgtt ttgcagcttg agcagaagga 1505581 taaggaatca atcgttcagc aaatgcaaag caataaagac tatagaaaaa atacacagcc 1505641 gtattcaagc ccttgtgcgg gaagcatatt cagaaatccg cttccgaatc atgccgggaa 1505701 ccttgtagaa aaagcaggct tgaaaggata tcaaatcggc ggtgcaaaga tatcggagat 1505761 gcacggaaac ttcatcgtca atgcgggggg agcatcagca aaagatgtgc ttgatctcat 1505821 tgaccatgtg aaaaagacaa tccgtgaaaa atacgagatt gatatgcaca cagaggttga 1505881 aatcatcggc ggaaatcgct gattcaagtt ctgactgaag ctgttcatat gatatactgt 1505941 aagcaaacga caaacggcat catagtatgc cgtttgtttt ggaatagaca gacttttaac 1506001 agctgtttca tttgaatgag gtgaacaggc aatgaacccg ggtcaagacc gagaaaaaat 1506061 cgttaacatt gaagagcgga tccctaaaat taaagagcag aggaaacaaa aggcaaaccg 1506121 ccgtctcatt tcatttatta tgctcttttt tattatggtg ctgatcattg tgtacctgca 1506181 aacaccaatc agtaaagtat caacaatctc tgttacaggg aatgaaaatg tatcaaaaaa 1506241 ggaaattatc gacctttccg atattaacag cggagatact gagttttgga gtttggacaa 1506301 gcaaaaaaca gaaaagaaga ttcagcaaaa taaattagtg aaaaaagcgg agatcagcaa 1506361 atcgcttcct aataaaatca acattgcaat cgaagaatat aaagcgattg cttatttaga 1506421 aaaagacgat gtgtactatg aagtgcttga aaacggctca gttctgccaa acgaagtaac 1506481 gccggatgat gccggaccga ttttagtgaa ttggacaaac gcgaagaagc ggtctcaaat 1506541 ggccaagcag ctcgatgcgt tgtcaaattc gttaaaacag tcgatttcag aaatttatta 1506601 tacgcctgta aaaatggatg aaaaccgtat taagttgtac atgaacgacg gttatgttgt 1506661 tacggcatct attaaaacgt ttgcagaccg aatgaagacg tatccttcta tcatctcaca 1506721 gctaagcagc aataaaaaag gaatcattca tttagaagtt gccacctatt ttgaagagtt 1506781 tgggaaaaac gataaagctg ctaaaaagga agatgaaaat tgaggggcaa atcagcagtc 1506841 cttctttcct tgattatgct tatcgcaggt tttttgattt cattttcttt tcaaatgaca 1506901 aaagaaaaca acaaaagcgc ggctgagacg gaagagtgga aaaaagaata tgcgctgaga 1506961 gatgaactgc tgaaacaaga gaaagaaaat aagaagtttg aaaaagaatt atatcaaaag 1507021 caaaacaaag tccgccaggc ggaaaataag ctgaagaaag agaagtcgga atactataat 1507081 gtcctcgaag atacagaaaa atacaggatg tatattgggg aagtcggtgt gcagggagaa 1507141 ggcgttgagg tgacattgga agatgcgtca tacataccgg aaggggagaa tgtgaatagt 1507201 tacatcgttc acgaaagcca tatcttccaa gtagtaaacg aactgtatat ctcaggagcg 1507261 gcagctgtcg ccgttaatgg acagcgtttg acgcatgatt cgtatatcaa atgcaatggt 1507321 cctgtggtaa cggtagacgg ggtgcagcat cccgctccgt ttacggtatc cgctattgga 1507381 gatccagatg tcctgctgcc ctcgttaaat atcgctggag gcctaattga tcagctgtca 1507441 atggatcata tttctgtgtc ggcagaaaaa gagaaaaacg tacaaatgaa accgattctg 1507501 aaaacgaagg aatgactgaa aaagcgggtg aaatagattg aaaataaagc gttccttcat 1507561 aagcatcagt gttcttatgg tcatcttcgg cctgatgata tctgttcagt ttaattcgtt 1507621 aaagcacccc aaagtccggg atacaagaga tatgtgggat attagggaag agctgacatc 1507681 agagcagaag aagcaggaaa agctgctggc tgaaataaac aaatatgaca aattgctgaa 1507741 tagctattcg caaacgaaag aaatgacaaa agaaaccgcg ctaaataata ccttgcaatc 1507801 cttaaaaaaa acagccggca tgaccgatat aacaggtagc ggaattgtca ttacgatttc 1507861 cccgcttttt tctgaaagct taacaggaga gccgatcgaa aatccgcctc cggatttgct 1507921 gaaaaagctg ataaatgaac tcaactccta cggtgcagag catatctcga ttaatgagcg 1507981 aagagttgtg aatcatacag tcatcagaga tataaacggc actacaaaaa tagacggata 1508041 cgcccttgac gattatcctt taacagtaaa agtgcttgcc aaagatccgg acatgttaca 1508101 cagcagagtg aaggggtcag gccttgagga tctttttgca tctgaaaatt tagcattaaa 1508161 agccggtaaa tctgaaagca aactaacatt aaaagcatat gacagaccac tggacgtaca 1508221 acagctgaaa ctgcttaaag actgaaaagg aggagaattg tcatgtggct gcccgtgttg 1508281 ggactggtgc tcggaatagc gattggacta atgacaaact taacgatacc gagtgaatac 1508341 tcaaactatt tatcgcttgc ggtgcttgcc gcacttgata cattaatcgg cggaatcagg 1508401 gcgcatttac aaggtacata tgatgaaatg gtatttgttt ccggtttctt ttttaatatt 1508461 atattggcaa taagtttagc ttttctggga gtccatcttg gtgtagactt gtatttagca 1508521 ggtatattcg catttggagt cagattattt cagaatatag ccgttatcag aagaaatcta 1508581 ctaacaaagt ggactctttc taaaaaaaat aaaaaaaatg tgatataaaa gaggatatac 1508641 ataggatata acgaatattt tcaataaaca taaaatgtga aaagcacata aaaatattct 1508701 gttgttattt tttgttacac acttgtaaag ccacattcat tgtattgttg ttccgcaaat 1508761 aatagaatag aaatgatcga aatgtgagga ggtgccatag aatgaacaac aatgaacttt 1508821 acgtcagtct tgacatcggt acgtccaata caaaagtgat cgtcggagaa atgacagatg 1508881 attcccttaa tattatcggt gtgggaaatg taccgtctga agggttgaaa aaaggctcaa 1508941 tcgttgatat agatgagacc gttcattcta taagaaaagc gtttgaccaa gctgaaagaa 1509001 tggtaggttt tccgcttaga aaagctattg tcggcgttaa tggaaattat atcaatattc 1509061 aagatacaaa cggtgttgta gcagtttcca gtgaaaataa agaaattcag gttgaagatg 1509121 tacgccgtgt catggaggcg gcacaggttg tttccgtacc gcatgaacag ctgattgttg 1509181 acgtcattcc taaacagttt atcgtagatg gaagagatga aatcaccgac ccgaaaaaaa 1509241 tgctgggtgt gcgtttagaa gtagagggca ccttgatcac cggttcaaaa acaatcttac 1509301 ataacttact ccgctgcgtt gaaagagctg gtattgaaat aactgatatt tgccttcagc 1509361 cgctggcagc cggttctgct gcattatcaa aggacgagaa aaaccttggt gtggctctca 1509421 ttgatatagg gggagggtca acaaccattg ccgtattcca gaacggacat ctcacttcta 1509481 cccgtgtcat tcctctcgga ggcgaaaata tcaccaaaga tatctccatc ggattgagaa 1509541 cgtcaacaga agaagcagaa cgcgtgaaaa agcaacttgg acatgcctac tatgacgaag 1509601 cctcggaaga tgaaatattt gaggtaaccg ttataggcac caatcaaaaa caaacattta 1509661 cacagcaaga agcagcgaat atcattgaag cgagagtaga ggaaattctt gaaattgttt 1509721 cagaagagct tcgcagtatg ggaattaccg atctgccggg aggcttcgtg ctgacaggag 1509781 gacaagcagc tatgccgggt gtcatgtctt tggcacagga tgtgctgcaa aacaatgtca 1509841 gagtggcaag cccgaattat atcggtgtaa gagatcctca atatatgacg ggagtgggcc 1509901 tgatccaatt cgcctgccgg aatgcaagaa tccaaggcag aaaaataggc tttaagatgc 1509961 ctgaagaagc gatacaggaa atcgcagtct catcatctga ggaacaagag cagcatcatc 1510021 accaaaatga ggtgcagcag cggccaaaag gaaaacaaaa aacacaagcc gaacataata 1510081 aacagagcaa aatgaaaaaa ctattaagca tgttttggga atagatagat agtcattcgg 1510141 cagattagga ggatttagca tgttggagtt cgaaacaaac atagacggct tagcatcaat 1510201 taaagtaatc ggagtaggag gcggcggtaa caacgccgtt aaccgaatga ttgaaaatga 1510261 agtgcaagga gtagagtata tcgcggtaaa cacggacgct caagctctta acctgtcaaa 1510321 agcagaagtg aaaatgcaaa tcggcgcaaa gctgactaga ggattgggag caggtgcgaa 1510381 tccggaagtc gggaaaaaag ccgctgaaga aagcaaagag cagattgaag aagcacttaa 1510441 aggtgctgac atggtattcg tgacagctgg tatgggcggc ggaacaggaa caggtgccgc 1510501 accggttatc gcacaaatcg cgaaagactt aggcgcatta acagtcggcg ttgtgacaag 1510561 accgtttacc ttcgaaggac gcaaaagaca gcttcaggct gcaggcggaa tctcggcaat 1510621 gaaagaagcg gtggatacac tgatcgtgat cccgaacgac cgtatccttg aaattgttga 1510681 taaaaacaca ccgatgcttg aagcattccg cgaagcggat aacgtacttc gccaaggggt 1510741 tcaaggtatt tctgacttga ttgctacacc tggtcttatc aaccttgact ttgctgatgt 1510801 gaaaacaatc atgtcaaaca aaggatctgc tttgatgggt atcggtattg ctactgggga 1510861 aaatcgcgcg gcagaggcag caaaaaaagc aatttccagc ccgcttcttg aagcggccat 1510921 tgacggtgcg caaggcgtcc tcatgaacat cactggagga acaaacctca gcctatatga 1510981 ggttcaggaa gcagcagaca ttgtcgcttc ggcgtctgat caagacgtaa acatgatttt 1511041 cggttctgtt attaatgaaa atctaaaaga tgagattgtg gtgacagtga ttgcaaccgg 1511101 ctttatcgaa caagagaagg acgtgacgaa gcctcagcgt ccaagcttaa atcaaagcat 1511161 caaaacacac aatcaaagtg ttccgaagcg tgagccaaaa cgtgaggaac ctcagcagca 1511221 gaacacagta agccgtcata cttcacagcc ggctgatgat acgcttgaca tcccgacatt 1511281 cttaagaaac cgtaataaac gcggctaatg taaaggacaa aatcgttttc gattttgtcc 1511341 ttttttgttt ttctcttcac actttccttc ttataaagtc tttttcccta ttgcttcctt 1511401 cgcttagtaa caaaacagat aattagaccc atttattttt gtgacatttt tatcattttc 1511461 atatatatgg aaattgaatg acatgaaacg acaatatctg taattcagat tgtctacagt 1511521 taatatacag cgatgttctg acaaaccatt cattattaaa aggagggacg acactttttt 1511581 taaaaagcat gttgaaaaag ggggatgaaa atgaggaaaa aaacgaaaaa cagactcatc 1511641 agctctgttt taagtacagt tgtcatcagt tcactgctgt ttccgggagc agccggggca 1511701 agcagtaaag tcacctcacc ttctgttaaa aaggagcttc aatctgcgga atccattcaa 1511761 aacaagattt cgagttcatt aaagaaaagc tttaaaaaga aagaaaaaac gacttttctg 1511821 attaaattta aagatctggc taacccagaa aaagcggcaa aagcggctgt taaaaaagcg 1511881 aaatcgaaga agctgtctgc cgctaagacg gaatatcaaa agcgttctgc tgttgtgtca 1511941 tctttaaaag tcacagccga tgaatcccag caagatgtcc taaaatactt gaacacccag 1512001 aaagataaag gaaatgcaga ccaaattcat tcttattatg tggtgaacgg gattgctgtt 1512061 catgcctcaa aagaggttat ggaaaaagtg gtgcagtttc ccgaagtgga aaaggtgctt 1512121 cctaatgaga aacggcagct ttttaagtca tcctccccat ttaatatgaa aaaagcacag 1512181 aaagctatta aagcaactga cggtgtggaa tggaatgtag accaaatcga tgccccaaaa 1512241 gcttgggcac ttggatatga tggaactggc acggttgttg cgtccattga taccggggtg 1512301 gaatggaatc atccggcatt aaaagagaaa tatcgcggat ataatccgga aaatcctaat 1512361 gagcctgaaa atgaaatgaa ctggtatgat gccgtagcag gcgaggcaag cccttatgat 1512421 gatttggctc atggaaccca cgtgacaggc acgatggtgg gctctgaacc tgatggaaca 1512481 aatcaaatcg gtgtagcacc tggcgcaaaa tggattgctg ttaaagcgtt ctctgaagat 1512541 ggcggcactg atgctgacat tttggaagct ggtgaatggg ttttagcacc aaaggacgcg 1512601 gaaggaaatc cccacccgga aatggctcct gatgttgtca ataactcatg gggagggggc 1512661 tctggacttg atgaatggta cagagacatg gtcaatgcct ggcgtgcggc cgatattttc 1512721 cctgagtttt cagcggggaa tacggatctc tttattcccg gcgggcctgg ttctatcgca 1512781 aatccggcaa actatccaga atcgtttgca actggagcga ctgatatcaa taaaaagctc 1512841 gctgactttt ctcttcaagg gccatctcca tatgatgaaa taaagccgga aatatctgca 1512901 ccgggcgtta atattcgttc atccgttccc ggtcagacat atgaggatgg ttgggacggc 1512961 acatcaatgg cagggccgca tgtatccgct gttgctgcac tgctgaaaca ggcgaatgcc 1513021 tcactttctg ttgatgagat ggaggatata ttaaccagca cggctgaacc gctcacggat 1513081 tcaacatttc ctgattcacc gaataacgga tatggccatg gtctggtgaa tgcttttgat 1513141 gctgtatccg ctgttacaga tggattaggg aaagcggaag gacaagtttc tgtagagggg 1513201 gatgaccaag agcctcctgt ctatcagcat gagaaagtaa ctgaagctta tgaaggtggc 1513261 agcctaccac tgactttgac agctgaagac aatgtgagtg tgacatctgt aaagctgtcc 1513321 tacaagcttg atcaaggtga atggacagaa ataacggcta aacgaatcag cggtgatcat 1513381 ctaaaaggaa cgtatcaggc agagatccca gatataaaag gaactaaact aagctataag 1513441 tggatgattc acgattttgg cggtcatgtc gtttcgtctg acgtatacga tgtaacagtg 1513501 aaaccaagca tcacggcggg atataagcag gactttgaaa ctgcacccgg cggctgggtt 1513561 gcgagcggaa caaataataa ctgggaatgg ggagttccgt caactggccc aaatacagca 1513621 gcatccggag aaaaagtata tggaacgaat ttgacaggaa attatgccaa ctcagcaaac 1513681 atgaaccttg ttatgcctcc tattaaagca cctgattcag gaagtctgtt ccttcaattt 1513741 aaaagctggc acaatttaga ggatgatttt gattacggct acgtttttgt tcttccggaa 1513801 ggtgaaaaga attgggagca ggctggtgtc tataacggaa agacatcaag ctggacggac 1513861 gaagaaattg atttatcggc ttataaaggc caaaacattc aagtgatgtt taaccttcaa 1513921 tctgatgaaa gcattgcaaa agagggctgg tatattgatg atgtagtgct ttctgacaaa 1513981 tcagccggaa aaacagtcaa aaagaataag ctgggcgtcg aaaagccgtc tggaaagcaa 1514041 aagaaaaagc cagtaaatcc gaaaaaggct aagccatctg caaacacagc ggtaaaacat 1514101 cagaacaagg ctatacagcc tcaagttttg ccgctcaagg cacaagtcag tgtagtggaa 1514161 acaggaaaat caacatattc agatcaatcc acagggcagt acacgctgaa gcacaaagcg 1514221 ggagactata cgcttatggc agaagcatat ggttatcagt cgaaaacaca aaaagtatct 1514281 ttaaagacgg atcagacgac acaagctaat tttacgttag aagagatgaa gaagggcaca 1514341 ttaaaaggca cggtcatcaa taaaacgaca ggagagccgg taacaggcgc ttccgtttat 1514401 gttgtagagg atgctgcggt ggaaccggct atgacaaacg acaaaggtga atatatgctg 1514461 gaggcctatg aaggcgctta tacgattaaa gtcgctgcac cgggttatta cagtgatgaa 1514521 ttttccgttg agttaaaagg tgatgttaca aaagaaactg cattgaagcc tttcgtcggt 1514581 tatccgggtg aaattgcata tgatgacgga acagcggaga atgccaattc ctattttgct 1514641 gccggtaacg gatgggcggt aaaaatgacg ctcgctgacg gcaaggacaa aggcatgctt 1514701 acaggagggc tgttcagatt ctgggataca gagttccctg atccgggcgg cacagagttt 1514761 aaggttgagg tatacgatgc cacaggaaaa gacggagcac cgggcaagaa aattgcaggg 1514821 ccatttaacg cggaagctct tcgcaatggc gagtggacta aggtagatct cagttcaaaa 1514881 gggattatgg tcgataaaga tttttatctc gtatatatcc agtcgaaacc tgatccgtat 1514941 tcacctggat tggcaatgga tgaaaccggc cagaattccg gccgcaactg gcagtatata 1515001 gatggaaagt ggcagccagg tgacaaagcg gatggcaact atatgattcg cgcattagtt 1515061 gattatgaag ctgctgtacc tgagattact tcaccgacag acaaatcata cacaaataag 1515121 gatagcgtca ctgtaaaagg aaacgcttct cctggcacaa cggtacacat ttataatgga 1515181 gagaaagaag caggagaaac gaaagctgct gcggatggca cgttccatgc aggcatcata 1515241 ctcaacaagg gtgaaaatga gctgacggca actgcatcaa ctgacaacgg aacaacagat 1515301 gcctccagcc caatcacggt cacgcttgat caagaaaagc ctgaattaac actggacaat 1515361 ccaaaggatg gcgggaaaac aaataaagaa acgctgactg tcaaaggggc tgtatccgat 1515421 gacaatctga aagacgtcaa ggtgaatggc aaaaaagcaa cagtagctga tggttcatac 1515481 tcagcccgta ttcttttgga aaatggaaga aatgaaatca aggtaattgc tacagacttg 1515541 gcaggcaaca aaacgacgaa aaagacagtc attgatgtga actttgacaa gcctgtcatt 1515601 tccggcttaa ttccgggaga ggataaaaac ttaaaagccg gtgaatctgt gaaaatcgct 1515661 ttctcaagcg ctgaggattt agatgcaacg tttaccattc gtatgccgct gaccaatgca 1515721 agagcgagtg tgcaaaatgc caccgaactc ccgttaagag aaatctctcc ggggagatat 1515781 gaaggctatt ggactgccac ttcttctatt aaagcaaaag gagcaaaagt agaagtgatc 1515841 gtccgagatg attatggaaa tgaaacaaga aaaactgcga atggaaaact taatatgaac 1515901 acagaaaatt aagtggaaaa aaagctgccg tcattggcag ctttttttat atcctctcat 1515961 tatacttcct cgacaaatta agcagatttc cctgaaaaat tgtattttcc tctcaacatt 1516021 aattgacaga ctttcccaca gagcttgctt tatacttatg aagcaagaag gggaacagcg 1516081 tgaggcaaga aagaaaggag tcagatgtga aaatctattt agatgtcatt tggctgttaa 1516141 acttttgttt tgatgcactt ttgcttttgc tcacggcatt tattttaaaa cggcatgtaa 1516201 aaaaaagaag actggtaggc ggagcgttca tcggttccag tattgtcctt ttgatgttta 1516261 ctcctttttc gccgattgtt gaacatccgg ctgggaagct agctttttca gttgtgattg 1516321 tggtggtgac atttggcttt aaaagatttc ggtttttctt tcaaaatttg ttttcctttt 1516381 attttgccac ttttttaatg gggggaggaa ttatcggagc ccattctttg ctgcagtcaa 1516441 attctattgt tcaaaacggt gtcatgatta ccaatcaaac agggtttgga gacccgatca 1516501 gctggttgtt tattgttggt ggctttccag cattatggtt tttttctaaa agaagaattg 1516561 aagatattga aacaaaaaac attcaatatg aggaacgagt cagcgtgcag gcagatttgg 1516621 gcagccaaac acttcatgtc agaggcctga ttgattccgg taaccagctg tacgatcctc 1516681 ttacaaaaac accggtaatg atcatttaca ttgataaact ggagccgatt ttcggaacag 1516741 ccgaaacgat gatcattcga aacacagacc cattggaagc catcgaacag ctcgatgatt 1516801 cctttcgctt tttagataaa atgaggttga ttccatacag gggagttggt cagcaaaatc 1516861 aatttttatt atgcgttaaa ccggatcacg taacgattat gacaaaagaa gaaatgattt 1516921 ctgcagataa atgtttaatc ggtatcagca caacaaagct gtcggcagat ggagagtttg 1516981 acgcgattat tcatccgaaa atgctttcgg gcaaggctgt caaacacgtt tcataatgtt 1517041 cgcaaatgtc cgttacttat catactcaaa cggcgtgaca tttagaaggg agaggaagat 1517101 gaaaaaactg aaattacggt tgacgcacct ctggtataag ctgctgatga aacttgggct 1517161 gaaaagtgat gaagtctatt acataggcgg gagtgaagcc ctgccgcctc cattatctaa 1517221 agatgaggag caggttttgt taatgaagct cccaaacggc gatcaggcgg cgcgcgccat 1517281 tctaattgaa cgcaatttgc gtctggtcgt atatatcgcc cgtaaatttg aaaatacggg 1517341 aattaatata gaggatttaa tcagcatcgg taccatcggt ctaatcaaag ctgttaatac 1517401 atttaatcca gaaaagaaaa tcaagcttgc tacctatgcc tcccggtgta tagaaaatga 1517461 aatcctgatg tatttaagaa gaaataacaa aatccgttca gaggtttcct ttgatgaacc 1517521 gcttaatatt gattgggacg gcaatgagct tttgctttct gatgtgctcg gcactgacga 1517581 tgacatcatc actaaagaca tagaagctaa cgtcgataaa aagcttttga aaaaagcgct 1517641 tgaacagctt aatgagagag aaaagcaaat catggagctg cggtttgggc ttgtcggtga 1517701 agaagaaaaa acccaaaagg atgtagcgga tatgatgggg atttctcagt cttatatttc 1517761 gcggcttgag aaaagaatta taaaaaggtt gagaaaagag ttcaacaaaa tggtgtaaaa 1517821 aattttatgg ttagaacccc ttgattttac agggatttcc tgatttcgac agtttttcgg 1517881 tctgagtgca gtgcatattt ttcccaccca aggagatact taacgttgta cagcagctcc 1517941 tgtagggagg gaaaaaagtg tcgagaaata aagtcgaaat ctgcggggtg gatacctcca 1518001 aattaccagt actcaagaat gaagagatga gaaagctgtt taggcagctg caggatgaag 1518061 gcgatgattc agcaagagaa aagcttgtaa acgggaactt gcgtcttgtc ttaagtgtca 1518121 ttcaacgatt taataacaga ggggagtatg ttgatgactt atttcaagtc ggctgcatcg 1518181 gactaatgaa atccattgat aattttgacc taagccacaa tgttaagttt tcaacatacg 1518241 ctgtacctat gattatcgga gagatccgca ggtatttacg tgataataac ccgatccgtg 1518301 tctcaagatc actccgggac atcgcttaca aggcgcttca ggtaagagag cggttaatca 1518361 gtgagacaag caaggagccg actgcagaag acatcgcaaa agttcttgaa gtaccgcatg 1518421 aggaaattgt atttgcgctt gatgccattc aggatccggt ttctctattt gaaccgatct 1518481 ataacgacgg cggagacccg atctatgtga tggaccaaat cagtgatgag cgtaatacag 1518541 attcacaatg gattgaagag ctggctttaa aagagggcat gagaaggctg aacgataggg 1518601 aaaaaatgat tttgagaaag cgattcttcc aagggaaaac ccaaatggaa gtcgccgagg 1518661 aaatcggaat ttctcaagcg caggtgtcca gacttgaaaa agcggctatc aaacaaatga 1518721 ataaaaatat tcatcaataa tgaaaagcct ttaaaacgat gttgttttaa aggcttttct 1518781 attgattatg gatggtttac gttttggaaa aagtaaggta tcctagttcg tacaaagttt 1518841 tatgaaaatt aaaacaatta taaaaggcaa taaagaggag gaccacgatg attttgcagc 1518901 ttgacaatgt ctcactaaaa cggaatggga aatggatact gaaagatatt cattggaagg 1518961 tggaagaaaa ggaaaattgg gtgctttacg gcctaaatgg cgccgggaag acagcgctgt 1519021 taaatatgct ttgctcatat tattttccaa catcaggcga gatgcaggtg ctcggccatg 1519081 aatttggcaa aacagagctt ggggaaaagc tcagacgtaa aattggcctc gtctcagcag 1519141 ctcttcagca aaaattgtat ccggcagatt cagcttttga aattgctttg agcggagctt 1519201 acgcttcgat tgggttatat gaaacgccaa gtaaggaaac cagggaaaaa gcgataggtt 1519261 tgttagagga cttgggagca attgaatatg ccgatcgccg ctatgaaacc ctttctcaag 1519321 gggaaaaaca aagagcattg attgctagag cactaatggc cgatccggag ctgctgatac 1519381 tggatgaacc agtcacagga ctggatttta ttgcccggga aaagctgtta gatacgatta 1519441 catacattgc aaacaaagaa aatgcaccat ctatccttta tgtgactcat catgctgaag 1519501 aaattttgcc tgtctttgat aaagcccttt tattaaaaca gggagaggtt tttggatccg 1519561 gagaaataaa ggaaatgctt actgatcaaa tactttccgc tttttttgat acgccaatcc 1519621 atgtattatg gaatcaggat cggccgtttt taacaagagc tgagccgata acgaatgcct 1519681 gacaaatata tatagattca tcctaggggt gctttgcgaa gctgagagag actttgtctc 1519741 aacccttttg acctgatctg gatcatgcca gcggagggaa gcggtgaaaa gcggagtaca 1519801 tcggactccg tttgttttta ttaagccgtt tcatcacatt tgaaacggct tttttgattt 1519861 taaagaatag gagcggattt acattggatc aacaaatata ctctttgcaa aaaaaagtgg 1519921 aagaacataa ggaggagctt attcagcttg cgaaaacgct gatttcttat caaacacctg 1519981 ctccgcctgc aagaaataca gagggcattc agtcttggat tgcgggatat ttaaatgaat 1520041 tgggattctc gatcgacaaa tgggatgtgt accctggaga tcccaatgtt gtagggaagc 1520101 taaaaggaac agattcagca gattattata gcctgattat caatggccat gtagatgtgg 1520161 cagaggtaaa agaggatgaa gaatggaagc acgatccgtt tcatcccatt gaaaaaaacg 1520221 gtctcttaat cgggcgaggc gcttccgata tgaagggcgg aatggcttgt gtgctgtttg 1520281 ctgtcaaatt aattcgtgaa gcaagcattg aacttccagg tgatctgatt ctgcaatcgg 1520341 ttattgggga ggaagttgga gaggccggca cacttgaatg ctgcaagagg ggctaccacg 1520401 ctgattttgc aattgtcgcg gatacgagcg atatgcatat tcaaggccaa ggcggtgtca 1520461 ttacaggctg gatcgaaatc aaaagcagtc aaacatttca tgatggaacg agacggaata 1520521 tgattcatgc aggcggagga acattcggag caagcgcaat tgaaaaaatg gcaaaaatca 1520581 ttgcggggct cggtgaactt gagcgccact ggtctattat gaaaagttat cccggtttta 1520641 aaccaggcac aaatacgatt aacccggcag ttatagaagg cggcagacat gcggctttta 1520701 tagcggacga atgccggctg tggatcacag tccattttta tccgaatgaa acccatgacc 1520761 aagtggcagc ggaaatagaa gattacgtca atcggctgag tgacagtgat atttggctta 1520821 gggaaaaccg ccctgtattc aagtggggag gctcatctat gatagaagac aggggagaaa 1520881 tttttccggc attggaagtt gaccctggcc acccaggcgt cttagcgcta actgcctctc 1520941 atcagaaagt gaaacgggag tgtccaatta ttgacgtttc tcaatcagtt acagatggcg 1521001 gatggctgta tgatgccggt attccatgcg taatatacgg tcctggagat ctgcacaatg 1521061 cacactctgt gaacgagaag gtatcgattg agcagctagt agagtataca aaaattatac 1521121 tcgattttat catcagctgg tgcagccgga aaaaagaaca atgacatgaa aatttcttct 1521181 tgctgacaag gttcagcctg cccgttcata tacttgaaca aaaggacgga aaaaggacgt 1521241 gatggaatga tcagcatttc agaatttcag gtaaaggatg tcgtcaatgt ctcaaacgga 1521301 aaaaagctgg ggagtattgg tgatattgat atcaatgtga ccactggaaa aattcaggcg 1521361 atcatactcg gaggaaatgg gaaagttctc ggattttttg gaaaagaaga ggaattggtc 1521421 attccatggc gaaatatagt aaaaatcggg gaagatgtaa tcttagtccg attaagtgaa 1521481 ccacatgcat aaacctgctt gtctgccgca gattggcaaa tgccggaagt ctcgattctt 1521541 ccggcacatt tcatttagaa atatgcaaat cggcgctcaa cgaatgcagt aagatgtggt 1521601 aaaataagtg ggaaattccg cttttttaaa tgtttgtcga aaggttggat catcatgaat 1521661 acatatcacc cattcagtct taccacaccc tcgacactca tgatacaaga ctgggctcaa 1521721 acgaatcaaa acaacaaaga ggtcattgcc ggatttacga caaaaaacgg cggtgtcagc 1521781 caaaagcctt ttgaatcgtt aaatacagga ttgcacgttc atgacaaaga tgcagatgta 1521841 gttaaaaatc gtgaatatat tgccgatatg tttaatactg atttgcagtc ttgggtattc 1521901 gctgatcaga cacatgataa tcgcgttcag aaagtgacgc agagggatag gggaaaaggc 1521961 gcccgtgagt atcacacggc tctaaaagca acggacggga tctatacaaa tgaaaaaaat 1522021 gtatttttag cattatgctt tgctgattgt gtgcctcttt tcttttatga tccggttaag 1522081 tcgcttgtcg gagtcgccca tgccgggtgg aaaggcaccg tcaaacagat tggcagagaa 1522141 atggtgaagc aatggactga gaaggaaggt tcaaatccct cagatattta cgctgttatt 1522201 ggcccgtcta tcagcggagc atgctatacg gtagacgacc gcgtcatgga tgctgtccgc 1522261 gcattgccgg tttcagcaga ccttgccgcc aatcagacgg caaaggcaca atatcagctt 1522321 gatctgaaag agctgaaccg tcttatactg atggacagcg gtttggcaag tgaacaaatt 1522381 tctgtcagcg gtttatgcac ggaaagcgag ccgtctcttt tctattctca tcgccgcgat 1522441 caggggaaaa ctggacggat gatgtccttt atcggaatga aggaggcata aaagatcttg 1522501 cgtgttgttg ataatttacg acatataaac gaacgaataa acgaagcatg taacagatcg 1522561 ggccgcagct ccgatgaagt tacggttatt gcagtcacaa aatatgtatc acctgaaaga 1522621 gcacaggagg cagtagatgc tggcatcacc tgcctcggag agaatcggga tgcggaactg 1522681 ctccgcaaac aggaattgat gaaagggaat ccggaatggc attttatcgg cagtctgcaa 1522741 tcaagaaaag caaaatctgt cgtcaattcg gtttcctata tccattccct agaccggctc 1522801 tcattagcga aagaaattga aaaacgggct gaaggtactg tacgatgctt tgtgcaggtc 1522861 aatacctctc ttgagccttc taaacatggc atgaaaaaag aagaagtcat tccattcata 1522921 caggagcttt ccggtttcga acatatcctt gttgccgggc tgatgacaat ggctccgctg 1522981 actgatgatc aagatcagat cagaagctgt ttcaggtcgc tgagagaact ccgtgaccag 1523041 gttcagaagc tgaaccagcc gaacgctccg tgtactgaac tgtcgatggg catgtcaaat 1523101 gattttgaaa ttgcaattga agaaggagct acttatatta gaatcggctc atcgttagtc 1523161 ggaaatgaaa cagggggtgt acagcaatga gtatgaaaaa taaactgaaa aactttttct 1523221 caatggaaga tgaagaatac gaatatgaat atattgagac agagcgggaa tctcatgagg 1523281 agcatgagca aaaagaaaag ccggcttaca acgggaataa acctgcgggc aaacagaatg 1523341 tagtgagctt gcaaagtgtt cagaaatcct ctaaagtggt gttgagtgag ccgcgcgttt 1523401 atgcggaggc gcaggaaata gccgaccatt tgaagaaccg gcgggcagtt gtcgtcaatc 1523461 ttcagcggat acagcatgac caggcgaagc ggattgttga ctttttaagc ggaaccgttt 1523521 atgccattgg cggcgatatt caaagaatcg gctcagatat tttcctctgc acgcctgaca 1523581 acgtagatgt atcaggcaca atttctgagc tcatatctga agacgaacat cagaggtggt 1523641 aaagcgagat gatcctttat caagtttttt cggttttaag cttattaatc acaatatact 1523701 catttgccct gatcatatat atttttatgt catgggtgcc gagtacgagg gaaacagcag 1523761 tcgggcgttt tttggcttcg atttgtgaac catatctcga accattcaga aaaatcatcc 1523821 ctccgattgc aatgctggat atttcaccaa tcgtagcaat acttgtgctt cggtttgcga 1523881 caaccggctt gtggggactt tatcgcatga ttgcgtttta atgtgacagt ttgatagggg 1523941 cttggcagca gccaagcctc tttacataga agggaaagac gatgagcgat atatatcagc 1524001 acttcagaaa agacgagcgg gcctttattg atcaagcgct cgaatggaaa agaattgtcc 1524061 aggagcagta ccggatgaag ctgaccgact ttttagatcc ccgagagcag gtcatcctct 1524121 ctgctgttac gggacaggca gatgtcgggc ttgccttttc cggcggctat gacagagcgg 1524181 agcggaaacg ggcgattctg tttccagagt acattactcc ggaagaatca gattttgaac 1524241 tgcaggcgtt taacgtccgt tatgctgaca agtttgtctc agtagatcat cgttctctgc 1524301 ttggtgcatt aatgggcata ggattaaagc ggcaaaaatt cggtgacatc gtgttttctg 1524361 agacagcagt gcaattgatt gtctcagccg ataccgctga ttttgtggct gcacagctga 1524421 cccaagcagg caaagcggcg gtcagcctag agaaaatcga cttgtcagac cttaacattc 1524481 cagcagttga tgtcgaaata agagatgaca cggtttcttc tttaaggctt gacgccgtct 1524541 gcgcctctat gagcaggcaa tcccgccaga aatcacagac gcttgtgaaa aacggccttg 1524601 tgaaagtgaa ctggaaggtg gttgaagatc cttcatacat agtcgcggaa ggggacatgc 1524661 tgtctatcag aggttttggc cggtgcagct taacaaaaat cgaaggaaaa accaaaaaag 1524721 acaaatggag agttacgttt gaacgacaaa aatagtcggt ttttcagttt ttttctccat 1524781 ctgtgcgaaa tttgttttat aatgtgaact agataaccgt actgaaatgt aaaaatggag 1524841 gtggcatcat gccattaacg ccaaatgata ttcacaacaa gacgtttaca aaaagttttc 1524901 gcggatatga tgaagatgaa gtaaatgaat tcctagccca agtcagaaaa gattacgaaa 1524961 ttgttctccg caagaaaact gagcttgaag cgaaagtcaa tgagcttgat gaaagaatcg 1525021 gacactttgc caatattgag gagacattga ataaatcaat tttagttgct caagaagcgg 1525081 ctgaagacgt aaaacgcaat tctcaaaaag aagcaaagct gatcgttcgg gaagcggaga 1525141 aaaacgctga tcgcattatc aacgaatcgt tatcaaaatc aagaaaaatt gcaatggaaa 1525201 ttgaagagct gaaaaaacag tctaaagtgt tcagaacacg tttccaaatg ctgattgaag 1525261 ctcagcttga tcttctgaaa aatgacgatt gggatcatct ccttgagtat gaagtcgacg 1525321 ctgtatttga ggaaaaggaa taaattctct gattatcttg acattttctt agcttgtcga 1525381 atataatacg ttcataaatt cagatgaaaa aacggttgaa agggacagtc atgtttcctt 1525441 caggccttca tagcgacccg gagatggtga gagtccggga tggccggaat catgtagatc 1525501 agccctttag tttccttgct gaactcacag taggttagga cgttcatcac gttacgatgc 1525561 tcaagaggaa aaagtgtatg cttgcttttt ctaaaagggt ggtaccgcga gataagcttt 1525621 ctcgtccctt atgggatgag agggcttttt ttattttctg aaaaaatgca gtggaggaat 1525681 gaaaatggat tttaaagaca cgctcttaat gccgaaaaca gatttcccga tgcgtggaaa 1525741 tttgccaaac cgtgagcctg acattcaaaa aaaatgggag gaagaagata tctaccgtct 1525801 tgttcaggaa cggacgaaag accgcccgaa atttgtttta catgacggac ctccgtatgc 1525861 aaacggcgac atccatatgg gccatgcact taacaagatt ttgaaagact tcattgtccg 1525921 ctataaatca atgagcggct acaacgcacc gtatgtgccg ggctgggata cacacggatt 1525981 gccaattgaa acagctctga caaaaaacaa aaaggtcaac cgcaaagaaa tgtcagtagc 1526041 ggaattccgc aaactatgcg aagagtacgc ttggaagcaa atcgagggac agcgtgagca 1526101 attcaaacgt cttggtgtcc gcggtgactg ggaaaaccca tatgtgacat taaaaccgga 1526161 atacgaagcg cagcaaatcc gcgtatttgg tgaaatggca aaacgaggct acatttacaa 1526221 aggccttaaa ccggttaact ggtcaccttc aagtgagtct gctctggctg aagccgagat 1526281 cgaatatcaa gataaacgtt cagcatctat ttacgtcgct tttggtgtaa aagacggaaa 1526341 aggcgttctt gaaaacggcg agcgcatcat catttggaca acaacgccgt ggacaattcc 1526401 ggcgaacctc ggaatctcag tgcaccctga tcttgagtac agcgtgattg cagtaggtga 1526461 agaccgcttt gttgtagcaa gtgccttagt cgaaaatgtt gcatcggcat gcggatttga 1526521 tcagtatgaa gtgacaagaa cggtcaaagg gaaagacctt gagaacatta tcgctgaaca 1526581 cccgctatat ggcagagact ctctcgttat gcttggtgaa cacgtaacaa ctgatgccgg 1526641 aacaggctgt gttcatacag cgcctggaca tggggaagat gactttatca tcggccaaaa 1526701 atacggttta gatgtgcttt gcccggtcga tgaaaaaggt gtaatgacaa gcgaagctcc 1526761 tggctttgaa ggcatgttct atgatgatgc aaacaaagcg atcacacagc agcttgatga 1526821 aaaaggcgca cttgtgaagc ttgaattcat tactcattct tatccgcatg attggagaac 1526881 aaaaaaacca accattttca gagcaacagc gcaatggttt gcgtctatta aagatttcag 1526941 atcagacctg ctggatgcca ttaaagaaac caaatgggtt cctgaatggg gcgagcagcg 1527001 tttgcacaac atggttcggg accgcggaga ctggtgtatt tccagacagc gtgcgtgggg 1527061 tgtgccgatt ccggtatttt acgctgaaaa cggagaaccg gttattacag atgaaaccat 1527121 tgaacatgtt tctgaattgt tcagacagca tggatcaaac atttggtttg aaaaagaagc 1527181 aaaggatctt cttccggaag gctttacgca tcctggcagc ccgaacggca catttacaaa 1527241 agaacaggat atcatggatg tttggtttga ttcaggctct tcacatcaag cagtgcttga 1527301 agaacgtgat gacctcgttc gcccggctga tctataccta gagggatctg accaatatcg 1527361 cggctggttt aactcttctc tttctacagc agtagccgta acagggaaag cgccgtataa 1527421 aggtgtgctc agccatgggt tcgcactgga tggagaagga cgtaagatga gtaaatcaat 1527481 cggtaacgtt gttgttccgg ctaaagtcat gaaacagctt ggtgccgaca tcttaagatt 1527541 atgggtatct tcagtggatt atcaggcgga cgttcgcgtg tctgacgcca ttctgaagca 1527601 ggttgcggaa gtatatcgta aaatccgcaa cacgttccgt ttccttcacg gcaacctttt 1527661 cgattttgat ccaaaaacaa atgcggtggc tgtcgaagat cttcgcgaag tggatcagta 1527721 tatgctgatt aagctgaaca agctgattga taaagtgaaa aaagcgtatg atgagtacga 1527781 atttgcggtt gtgtatcaca gcattcataa tttctgcaca atcgaattga gctcattcta 1527841 ccttgatttt gcaaaagata ttgtctacat cgagcatgcg gatcatccgg atagacgcag 1527901 catgcagaca gtattctacg aaacgcttct tgcattagtg aagctttcag cgcctatcct 1527961 tccacatacg gcagacgaat tgtggtctca tttaacattt gttgaagagc agagcgttca 1528021 gttgaccgat atgccggaaa caatcacggt tccaaacagt gaagcgactg aagaaaaatt 1528081 tgaccgcttt atggctcttc gtgatgacgt gttaaaagca ttagaaactg cgcgaaatga 1528141 aaaaattatc ggtaaatctt tggaagcaaa cctgaaattg tatccaaaca aagaaaacaa 1528201 ggagctcttg gcttccataa aagaaaacct ttctcagctg tttattgtgt ctgaactgac 1528261 aatcagcgaa gaaaatgaag cgccgaacga tgcgcaaagc tttgcgacgg gtaaaatcgc 1528321 tgtcgagaaa gcggaaggcg aaatgtgtga gagatctcgt gtgatttcaa aagatgtagg 1528381 ggcaaatccg aaatatccta cactttcatt acgcaacgct gaaatcgttg aaaaatacta 1528441 tcaaaaataa tgcaaaagag cccggcgtaa aagccgggct ttttttgtgc caagagtgac 1528501 atcctttaga acgaaaggaa aaatcttatg ggctttagat catcattcac aggcaacaat 1528561 aaagatacta cgttaagagc aggagttgtg aagaatgaat gatcaactga ccgcaattta 1528621 tacggaactt cttctgatga aagaagaatt acagtcgaga ttatttgagt attcttgctt 1528681 tcaggtttct acaagcccgc aagcagcaat caatcaaaaa caaaaagcaa ctctgatcta 1528741 tcatattaaa gaagaacttc aagacgttct ccttgcattg tccaaaatcg aaaacggcac 1528801 attcggatac tgtgaagaaa ctggggcccc cattcctctt gcaaagctgg cagtgctgcc 1528861 gacggcccga acagcaaacg attttcttta ttctgtccaa tttgagaaaa aaacgcttcc 1528921 gatatggaaa tcaacggata tcgaatatgg tcaggcactg tatgaataac agtgtctgtc 1528981 cggttaatat gcctgatatt tctttactcc agtgcttttt attgataaaa tgcataatgg 1529041 attaaagtaa ccgtaaactg gaggaacgtt tgtgctgtat tatatgattg cactacttat 1529101 tattgcagcc gatcaattga caaaatggct agttgttaag aacatggaac ttggccaaag 1529161 cattccgatc attgatcagg tattctatat cacctcccat cgcaatacgg gtgctgcatg 1529221 ggggatatta gcgggtcaaa tgtggttttt ctacctcata acaaccgctg ttattattgg 1529281 tattgtttat tacatacagc gttatacaaa gggacaaagg cttcttggcg ttgccctcgg 1529341 acttatgctt ggcggtgcca tcggcaactt tatcgatcgg gctgtcagac aggaagttgt 1529401 ggattttatc catgttatta ttgtcaatta caattacccg atatttaaca tcgcggactc 1529461 ttcactatgt gtcggcgtaa tgcttttatt tatacaaatg ctgttggaca gcgggaaaaa 1529521 gaaaaaggag caatagcatg aatcaaattg atataaccgc ttcagaagaa caaaaaagtg 1529581 agcggattga taaatttttg gcatcgactg agaatgattg gtcaagaacc caggttcagc 1529641 aatgggtaaa agacggacag gttgtcgtga acggaagcgc ggtgaaagcg aattataaaa 1529701 ttcagccggg tgatcaggtg accgtcactg tacctgaacc ggaagcgctc gacgtcctgg 1529761 cagagcctat ggatctggat atttattatg aggaccagga tgtgctggtc gtcaacaaac 1529821 ctcgcggaat ggttgttcac ccagcacccg ggcatcttac gggcacactt gtaaacggtc 1529881 ttatggctca ttgcacagac ctttccggaa taaatggtgt gatgcgcccg ggtattgttc 1529941 acagaatcga taaggacacg tccggtttat taatggtggc gaaaaatgat atggcgcacg 1530001 agtcactcgt aaaccaattg gtcaacaaaa cggtcacgcg gaaatatacg gcggttgtcc 1530061 acgggcttat ttctcatgat gacggcacaa ttgacgcgcc gatcggacgg gataaaaaag 1530121 accgtcaaag catgactgtg acacgtgatg gcaaaaacgc tgtcactcat tttcatgtgc 1530181 ttgagcgttt tcaggatttt acgttagtgg agtgccagct tgaaacaggg agaacccatc 1530241 aaattcgtgt tcatatgaaa tatatcggat tcccattagc aggcgatccg aaatacggcc 1530301 caagaaaaac aatcgacttt aatggccaag cgcttcacgc gggagtttta ggttttgacc 1530361 atccacgaac aggagaatat gtcgaatttg aagcgccgct tcccgaggat atggcagaat 1530421 taatcgaaaa cctcagaaaa aacggttgac agagggtttc ttttctgaaa taataaacga 1530481 agctgaatag attctttaaa acagtccaga gaggctgaga aggataacgg atagacggga 1530541 tgcgtgtata ggcgcgcacc ttgtcctaaa acccctctat gctctggcag gaggggtttt 1530601 ttcttctata tgaactgtga ggtgtcacac attgaatcaa aaagctgtca ttctcgacga 1530661 acaggcaatt agacgggcgc tgaccaggat tgctcacgaa atgatcgaac gcaataaagg 1530721 aatgaataac tgcattcttg tcggcattaa gacaagaggg atttacctgg caaaacgcct 1530781 tgcggaacgc attgaacaga ttgagggaaa tcctgttaca gtcggtgaaa ttgatattac 1530841 tctttacaga gatgatcttt ctaaaaaaac aagcaacgat gaaccgcttg taaaaggtgc 1530901 agatattccg gtagatatta cagatcaaaa agtcattctc gttgatgatg ttctgtatac 1530961 cggaagaaca gtcagagcag gaatggatgc gcttgttgat gtaggcagac cttcctccat 1531021 tcagcttgca gtgcttgtgg acagaggaca ccgggagctg ccgatccgag cggattatat 1531081 cgggaaaaac atcccgacat caaagtctga aaaggttatg gtacagcttg atgaggtaga 1531141 ccaaaacgat ctcgtcgcca tttatgaaaa cgaataatag atcacctttt taagggcaat 1531201 ccagagaggt tgcaaagagg tgcacaacaa aggcccaaaa agtattcggc aggtctttgt 1531261 atgcctcttt gcgtaaaaaa gcaaagaggt ttttttatac agtcattgag tcatcctaaa 1531321 atgaaagtca acaatcaggg ggaaatcatc atgagtaaga aaaaagtaaa tttaggggtc 1531381 agggatgtcc cgacaccttt ctcttgggtt tcattcagcc ttcagcattt gtttgccatg 1531441 tttggctcaa ccattttggt tccgaagctc gtcggaatga gtcctgctgt ggcgttggtg 1531501 acaagcggca tcggaacact ggcgtacctt cttattacca aaggacaaat tccggcgtat 1531561 ctcggttcat ccttcgcctt tatttctccg atcattctgg taaaagcgac cggcgggccg 1531621 ggagcggcaa tggttggagc gtttcttgca gggctggtgt acgggctgat tgccttattg 1531681 attaggcagc ttggaacagg atggctgatg aagattctcc cgcctgtagt cgtagggcct 1531741 gttattatcg tcatcgggct gggactggca agcactgcag taaacatggc gatgtatgct 1531801 gatccgaacg cgagtgagtt ggtctacagc ttaaagcact ttagtgtcgc aggagttacg 1531861 ctggcaatta cgattatttg tgcgattttc ttacgagggt ttttaagcct gattccggtt 1531921 ctgatcggaa tcatcggcgg atacctgttt gcccttactc aagggattgt caacttccag 1531981 ccggtgcttg acgcgaaatg gtttgcagtg cctgaattta tcattccgtt caaagattat 1532041 tcaccgtcag ttacgctcgg catcgcagcc gcaatggttc ctgtcgcatt tgtcacaatg 1532101 tcagagcata tcggccacca aatggtgctg agcaaggttg tcggacaaga cttcattaaa 1532161 aagccaggtc ttcatcgctc tattatgggt gacagtgtgg cgacaatcct cgcttccctg 1532221 atcggcggcc ctccgacaac gacttacgga gaaaacattg gcgtgctggc catcacaaga 1532281 gtattcagcg tctttgtcat cgggggcgcg gcagtgattg ccctttgctt cggctttatc 1532341 ggcaaaattt cagcgctgat cagttcagtg ccgtcagcgg tcatgggagg cgtctccttc 1532401 ctgctgttcg gaatcattgc ttcaagcggc ctgagaatgc tgattgacaa caaaattgat 1532461 tatgaaaaca acagaaacct cattattaca tcagttatcc ttgtcatcgg tgtaggaggc 1532521 gcttttatcc aagtgtctca gggcggattc caagtgtcag gaatggcgct tgccgcaatt 1532581 gtcggtgtca tcttaaacct gattcttccg caggcgaagg aagagcaggc agacacatct 1532641 gaacaacatc atatttaaaa ccttttaatg aaagtccaga gaggcttgga agggttatga 1532701 agagaaggaa gcttcaatgc tgccctctat ttaaccatac cccgagtcta tcttagaccg 1532761 gggttttttt tcagccttaa gttgaaaaga gaggggaaag aacatgaagc atttaacgac 1532821 gatgagtgaa cttagcactg aggaaatcaa agatttgctt caaacagcac aagagctcaa 1532881 aagcggaaaa acagacaatc agcttacagg aaagtttgca gcaaacctgt ttttcgaacc 1532941 gagcacgaga acgcggttca gctttgaggt cgcagaaaaa aagctgggca tgaatgtgct 1533001 taaccttgat ggaacaagca caagcgtgca aaaaggcgaa accttatatg acacgatccg 1533061 gacgcttgaa tcaatcggtg tggacgtctg cgtcatcagg cacagtgagg atgagtatta 1533121 tgaagagctt gtcagccagg tgaacattcc gattctgaat gcgggagacg ggtgcggcca 1533181 gcatccaaca caatcactgc ttgatttaat gacgatttat gaagagttca atacgtttaa 1533241 agggcttacc gtctccattc acggcgacat caagcatagc agagtggcaa ggtcaaatgc 1533301 ggaagtgttg acaagattgg gtgcccgggt cctattttcc ggcccttcgg aatggcagga 1533361 tgaagaaaat acattcggca cgtatgtctc aatggatgaa gcagttgagt cttccgatgt 1533421 tgtcatgctg ctgcgcattc aaaatgaacg acatcagtcc gctgtcagtc aggaaggcta 1533481 tttaaacaaa tacggcttga ccgtagaacg ggctgagcgt atgaagcggc atgcgatcat 1533541 catgcatcct gctccggtaa acagaggagt ggagattgat gacagcttag tagaaagcga 1533601 aaaatcaaga atcttcaagc aaatgaaaaa tggcgtattt atcagaatgg cagtgataca 1533661 gcgtgcctta caaaccaatg tgaaaagagg agaagcagcg tatgtcatat ctcattaaaa 1533721 acggctggat actaaacgaa aatggtgaaa aaacacaagc ggatatccga gtgactggag 1533781 aaaccatcac cgcaatcggc aagcttgatg caacggataa tgaaacggta attgatgcaa 1533841 aaggtttgct cgtttcacct gggtttgttg atctccacgt gcatttcaga gagccgggcg 1533901 gagagaaaaa agaaactatt gaaaccgggg caaaagcagc ggcgcgcggc ggctatacta 1533961 cagtagcagc aatgccgaat acgcggccgg ttcctgatac aaaggagcag atggaatggg 1534021 tgcaaaacag aattaaagaa acatcatgcg taagagttct tccatatgca tccattacga 1534081 tcagacaaat cggcgatgaa atgacaaact ttgaagcgtt aaaagaagcc ggggcatttg 1534141 cttttacaga tgacggcgtt ggtatacaga cagcaggaat gatgtatgaa gcgatgaaac 1534201 gggcagccgc aattgacaaa gcgattgttg cacattgcga ggacaactcc ttaatttacg 1534261 gagggagcgt acatgagggg acattctcca aagcgaacgg gctaaacggc attccttctg 1534321 tgtgtgaatc ggttcatatt gctcgcgatg tgctgctggc tgaggcggca aactgccatt 1534381 atcatgtatg ccatatcagc acaaaagaat ctgtcagagt tgtacgcgat gcgaaaaaag 1534441 cgggaatcag agtgacagca gaagtatcgc cgcatcattt gctgctttgt gatgaggaca 1534501 tcccggggct ggacacaaac tataaaatga atcctccgct ccgcagccca gaagacagag 1534561 ctgctttaat tgaaggtctt ttagacggaa caattgattt tatcgcaaca gaccatgcac 1534621 cgcatacgga agaagagaag aacacagaaa tgaagctggc gccattcgga attgtcggct 1534681 tagaaacagc attcccgctt ctttacacac actttgtcaa aaatggcagc tggtcactga 1534741 agcagctgat tgactacatg acaatcaagc catgcgaagc gttcggtctc ccatatggaa 1534801 cattacaaac ggggcaagct gcggacatta cgttaatcga tttagaaaaa gaagcagtta 1534861 tagacaaaga gacattttta tcaaaaggaa aaaatacacc attcaacggc atcagttgca 1534921 ccggctggcc ggtcgctaca attgcggcag ggaagcttgc ttatgaagag gggagacttg 1534981 tcaaatgaag agacgattag tactggaaaa cggagcggta ttcgagggag aagctttcgg 1535041 aagcttagaa cacaacatgg gagaagtcgt ttttaatact gggatgacag gctatcagga 1535101 aattttatct gatccttctt actgcggaca gatcgtaaca ttaacatacc cgcttatcgg 1535161 aaattacggc attaaccgtg atgattttga atccattacc ccttttgtca aagggctgat 1535221 catcaaagaa ttatgtgagc tgccttccaa ctggcgttca gcatacacct tagacgagta 1535281 tttaaaaatg aaaaacattc ccggactcca gggaattgat acaaggaagc tgacaagaat 1535341 gatccgcacg gcaggcgcgc taaaaggaac attcgcttca tctgatgaag atatcgaagc 1535401 agtgctgaaa agactgaacg aaacggaatt gccaagaaat caagtatccc aagtatcagc 1535461 aaaaacagca tatccgagcc cgggaagagg caaacgcatt gtcttggttg acttcggcat 1535521 gaaacacggg attctaagag agctgaacaa acggaaatgt gacgtcatcg ttgtgcctta 1535581 caacattaca gcggaagagg tgcttcagct gaaaccggac ggtatcatgc tttctaacgg 1535641 acctggagac ccgaaggatg tgcctgaagc gattgaaatg attaaaggtg ttcttggaaa 1535701 agtgccatta ttcggaatat gtctcggcca ccaattattc gcgctggcgt gcggggcgaa 1535761 tactgaaaaa atgaaattcg gccacagggg ctcaaaccac ccggtaaaag agctggctac 1535821 aggaaaagtt gccttaacat ctcaaaacca tggatataca gtttcgtcta tcagtaaaac 1535881 agaactggaa gtgacgcata tcgcaattaa cgacgatacg attgaagggc tgaagcataa 1535941 aacattgccg gcatttacgg ttcaatatca tcccgaagcc tcacctggtc ctgaggatgc 1536001 caaccatcta tttgacagat tcatcgaaat gatcgaaaca acagagaaag aaggggaagc 1536061 ggtatgccaa aacgcgtaga cattaacaaa attttagtaa tcggatctgg accgatcatc 1536121 atcggccaag cagcagaatt tgactatgcg ggaacacaag cctgtcttgc tttgaaagaa 1536181 gaaggctatg aagtcatcct tgtcaactca aaccctgcaa cgatcatgac agatacagaa 1536241 atggctgacc gggtttacat cgaaccgctc acacctgaat tcctgacacg aatcatcaga 1536301 aaagagcgcc cggatgccat tcttcctaca ctcggaggcc aaaccggttt gaatcttgcg 1536361 gttgagcttt ctgaaagagg cgttttggca gaatgcggcg tcgaagtgct tggcacgaaa 1536421 ctgtctgcga ttcagcaagc tgaagaccgt gacttgttca gaacattaat gaatgaactg 1536481 aatgaaccgg tgcctgaaag tgagattatc cactcccttg aagaagcaga aaaattcgtc 1536541 agtcaaattg gattccctgt cattgtccgc ccggcatata cattaggcgg aacaggcgga 1536601 ggcatctgct cgaatgaaac agagctaaaa gaaatcgttg agaacggctt gaaattaagc 1536661 ccggtacacc aatgtctgct tgaaaaaagc atcgccggct ataaagaaat cgagtatgaa 1536721 gtcatgagag acagccagga tcacgccatt gtcgtttgta acatggaaaa cattgatcca 1536781 gttggaatcc atactggaga cagtattgtt gtcgcgccga gccaaacgct cagcgatcgc 1536841 gaatatcagc tcttgcggaa tgtatcgtta aaactgattc gcgcgcttgg gatcgaaggc 1536901 ggatgtaatg tccagctcgc cttagatcca gacagcttcc aatattacat tattgaagta 1536961 aatccgcgtg tcagccgttc atctgccctt gcatcaaaag caacggggta cccgattgca 1537021 aagctcgctg ctaaaattgc agtcggactt tcattagatg aaatgatgaa cccggtgaca 1537081 ggaaaaacat atgcagcatt tgaacctgct cttgactatg tcgtatccaa aattccgcgc 1537141 tggccgtttg ataagtttga atcagcaaac agaaagcttg gcacgcaaat gaaagcgaca 1537201 ggtgaggtca tggcaatcgg ccgcacgctt gaagagtcat tgctgaaggc agtgcgatca 1537261 ctggaagcgg atgtgtatca tcttgaattg aaggacgccg ctgacatttc agatgagctt 1537321 cttgaaaagc gaattaaaaa ggccggtgat gaacgcttat tctacttagc tgaagcgtac 1537381 agaagaggct acacggtaga agacctccat gaattttccg ctatcgatgt cttcttcttg 1537441 cataagctgt tcggaatcgt acagtttgaa aaagaattga aggccaatgc gggcgataca 1537501 gatgtgctga gacgggcaaa agaactcggc ttctctgatc agtacatcag ccgtgaatgg 1537561 aaaatgaaag aatctgagct ttacagcttg agaaaacaag cggggattgc gccggtattc 1537621 aaaatggtag atacatgcgc ggcggaattt gagtcagaaa cgccatactt ctatagcaca 1537681 tatgaagaag aaaatgaatc tgtcgttaca gataagaaaa gtgtgatggt gcttggttcg 1537741 ggtccgattc gaatcggtca gggtgtcgag ttcgactatg cgacggttca ctctgtatgg 1537801 gcaattaaac aagcaggcta tgaagccatt attgtcaaca acaacccgga aaccgtttca 1537861 acagacttca gcatctcaga caagctgtat tttgaaccgc ttacgattga agatgtcatg 1537921 cacatcattg acctcgaaca gccaatgggc gttgtcgtac aatttggcgg acaaactgcg 1537981 attaaccttg ctgacgagct ttctgcacgc ggagtgaaaa tccttggaac ttcattagaa 1538041 gatttagacc gtgccgaaga ccgggataaa tttgaacaag cgcttggaga acttggtgtt 1538101 cctcagccgc ttggcaaaac agcgacatca gttaatcagg cggtaagcat cgcaagtgat 1538161 atcggttatc cggtactggt acgcccttcc tatgtacttg gcggccgggc gatggagatt 1538221 gtttaccatg aagaggaact gcttcattac atgaaaaatg cagtcaaaat caatccacag 1538281 caccctgtat taattgatag atacttgacc ggaaaagaaa ttgaagtcga tgcagtatcc 1538341 gacggtgaaa cagtcgtcat tccgggaatt atggagcaca ttgaacgtgc gggcgttcac 1538401 tccggagact caatcgctgt ttatccgcct cagtctctca cagaggacat taagaaaaaa 1538461 attgaacaat acacgatcgc attggctaaa gggctgaata ttgtcggttt gctcaatatt 1538521 caattcgtct tgtcgcaagg cgaggtgtac gtgctagaag tgaatccgag atcaagcaga 1538581 accgtaccgt ttttaagcaa aattacgggt atcccaatgg cgaatctcgc aacaaaaatc 1538641 attcttggtc aaaagctggc tgcgtttggc tatacagagg gccttcagcc tgaacagcaa 1538701 ggtgtatttg taaaagcgcc ggtcttctcc tttgccaagc tgagaagagt ggatattacg 1538761 ttagggcctg aaatgaaatc aacaggtgaa gtcatgggga aagattcgac acttgaaaag 1538821 gcgctctaca aagccttgat cgcttcaggt attcaaatcc cgaactacgg ttccgtgctt 1538881 ttaacagtag ctgataagga caaagaagaa gggcttgcca ttgctaagcg gttccacgcg 1538941 atcggctaca acattttagc gacggaagga acggcaggct acctgaaaga agcttccatt 1539001 ccagcgaagg tcgtcggaaa aatcggtcag gatggcccga acttgcttga tgtcatcaga 1539061 aacggagaag cgcagtttgt catcaatacg ctgacaaaag gaaagcagcc ggcaagagac 1539121 ggttttagaa tcagacgtga atcagtagaa aatggtgttg cctgcctaac atctttagat 1539181 acggcagagg cgatattgcg agtgctggaa agcatgacat tccgtgctga tcaaatgccg 1539241 gcagtcaaca caaatcagga ggcggcagtc actatatgaa aaaagcgtat ttgacagtat 1539301 gttctaacca gcaaattgca gaccgggtgt ttcaaatggt tctgaaaggg gagcttgtcc 1539361 aagggtttac aacccctgga cagttccttc atcttaaagt gagcgaagcg gttacgcctc 1539421 ttttgagaag gccgatcagc atcgcagacg tcaactttga aaaaaatgaa gtcaccatca 1539481 tttatcgggt agatggggaa gggacaagac tcttgtcact gaagcagcag ggagaacttg 1539541 tggatgtcct cgggcctttg ggaaatggct ttcctgttaa tgaagttcaa cccggaaaga 1539601 cggctttgct ggtaggaggc ggagtaggtg tgccgcctct ccaagagctg tcgaaacgct 1539661 tgattgaaaa aggggtaaat gtcatccacg ttttaggatt ccaatcggca aaggatgttt 1539721 tttacgagga agaatgccgg cagtacggag acacgtatgt ggcaacagct gacggaagct 1539781 acggggaaac cggatttgtc acagatgtga ttaaacggaa aaagctagag tttgatatcc 1539841 tcctcagctg cgggccgaca ccgatgctca aggcgttaaa acaggaatat gcccataaag 1539901 aagtatatct gtccatggag gaacgaatgg gctgcggaat cggcgcatgc ttcgcgtgtg 1539961 tgtgccatac aaacgaaagt gagacatcct atgtaaaagt atgtctcgac gggcctgtat 1540021 ttaaagctca ggaggtggcg ctgtaatgct agaggtgaaa ttgccgggac ttgatttgaa 1540081 aaacccaatc attcctgcat caggctgctt cggttttgga aaagaatttt cacgttttta 1540141 tgatttgtct tgtcttggag ctatcatgat taaggctacg acaaaggagc cgcgctttgg 1540201 gaatccgacg ccgcgggtag ctgagactgg tgctggaatg ctcaatgcga tcggtctcca 1540261 aaatccgggg ctggatagtg tgttgcatca tgagctgccg tggcttgagc agtttgatac 1540321 accgatcatt gccaatgtcg caggttctca agtcgatgat tatgttgaag tcgcagaaca 1540381 tatcagcaaa gcgcctaatg ttcatgctct tgaattgaat atttcctgcc cgaatgtgaa 1540441 aacaggcgga atcgcttttg gcacgaatcc tgaaatggct gccgatttga caaaagcggt 1540501 gaaagaggtt tcggatgtac ccgtttatgt gaagctatcc ccgaacgtgg ctaatatcac 1540561 agaaattgca ttagcgatcg aggaagcggg agcggacggt cttacgatga tcaacacact 1540621 aatcggcatg agactcgatt taaaaaccgg caaaccgata ttagcgaata aaacaggggg 1540681 actttcgggc cctgctgtga agccggttgc cattcgcatg gtgtatgaag tcagccagat 1540741 ggtcaacatc ccgattatcg gaatgggagg cgtgcaaacg gctgaagatg ccctggaatt 1540801 tcttctcgcg ggagcaagcg cagtcgctgt cggaacagca aactttgtga atccttttgc 1540861 atgtccagag attattgaac agctcccatc tgttttgctc caatacggct atcaatcaat 1540921 tgaagaatgc atcggaagga gctggaatca tgaaaaacaa cctgcccatc atcgcgcttg 1540981 attttgcgtc agctgaagaa acacttgcgt tcttagcgcc ttttcagcaa gaaccgttat 1541041 ttgtaaaggt tgggatggag cttttttatc aagaagggcc atctatcgtg aaacaactaa 1541101 aagaaagaaa ctgcgagcta tttttagatc taaagcttca tgacatcccg actactgtaa 1541161 acaaagcgat gaagcgcctt gccagtcttg gagtagacct cgtcaatgtt catgctgccg 1541221 ggggcaaaaa aatgatgcag gcagctctcg aaggcttaga agaaggtacg ccggctggaa 1541281 aaaaacgtcc gtcacttatc gcggtaaccc agctgacaag cacatctgaa caaatcatga 1541341 aagatgaact gctgatcgaa aagtctctga ttgatacggt tgtgcactac agcaaacagg 1541401 cggaagaaag cggactggat ggagtggtct gctctgttca tgaagcaaaa gccatttacc 1541461 aagcggtgtc gccttcattt ctgactgtca ctccggggat cagaatgtca gaggacgctg 1541521 cgaatgacca agttcgcgta gcgacgcctg ccattgcaag agagaaaggt tcatcagcga 1541581 ttgtagtagg acgctcgatt acaaaagcgg aagacccggt aaaagcctat aaggctgtca 1541641 gacttgaatg ggagggaatc aaatcttgaa acaaatcatc gcaaaacatc tattagacat 1541701 ccaagctgta tttttacgcc cgaacgagcc gttcacatgg gcaagcggca ttttatcacc 1541761 gatctactgt gacaaccgcc ttacgctatc tttcccagag gtcagaaacg atgttgcttc 1541821 aggtatcagc aagcttgtta aagagcattt tcctgaagct gaaatgattg cgggaacagc 1541881 aactgccggt attcctcatg ctgctcttgc ggcggaccat ttgaatcttc cgatgtgtta 1541941 tgtgaggagc aagccgaagg cgcacggaaa aggcaatcag attgagggag ctgtgcaaga 1542001 agggcaaaaa acagtcgtca ttgaagactt aatttccaca ggaggcagcg tgcttgaagc 1542061 ttgtgcagct ttacaagcgg ccggctgtga agtgcttggt gtcgtctcaa tctttacgta 1542121 cggacttcct aaagcggagg aagccttcgc aaaggcagaa ctgccatact actcattaac 1542181 cgattatgat acgctcacag aggtcgcgct tgaaaacgga aatattcatt cagatgatct 1542241 aaaaaagctg caaacatgga aacgaaatcc cgagtcaaaa gattggttta aaaaataaaa 1542301 aataaattca aatgatgtaa agaggcttca aagccttgct gtacttgaaa acaggctgtg 1542361 aggcctgttt ttttattaat cctataaaaa aagtcgggtt gacttatgtt agaattgtgc 1542421 taaaatttac tacaaatcta aaaacttatc aagagcggct gagggactgg acctatgaag 1542481 cccggcaacc tgcatagttt gtaaggtgct acttccagca aaatgaattc cattttgaaa 1542541 gataagggct gcatgctgtt cctgtctttc tttccgccgg attgaaagtt ttttatttta 1542601 agaggtaaaa aggctatctg tatatcagca gccgcgaatc acattacatg ggaaaagaca 1542661 accggcagaa agctactgtt tgtttgtctc cgaaaggagg aaagaagaaa tgttaacgta 1542721 tgataattgg gaagaaccaa cgattacatt tccggaagac gatccttata aaggagcgct 1542781 gtcagtttta aaatgggcat acggccatta cggcgatcag cttgtttatg cctgcagttt 1542841 cggaattgag ggaatcgttc tgattgactt aatttataaa gtgaaaaaag acgcagagat 1542901 tgtgtttctt gatacaggac ttcattttaa agaaacctat gaaacaattg aacgagtgaa 1542961 agagcgttat ccgggtctta atatcatcct gaaaaaacca gatctcaccc ttgaggaaca 1543021 agccgaagaa catggtgaca aactatggga aagagagccg aatcagtgct gctatcttag 1543081 aaaggtcgtt cctttaagag aggcgctttc aggacatcca gcctggcttt ccggcctgcg 1543141 ccgtgatcaa gggccaagcc gtgccaatac gaatttctta aacaaagatg aaaaattcaa 1543201 gtcagtaaaa gtttgcccgc ttatccattg gacttggaaa gacatttgga gatatacatc 1543261 ccggaatgaa ctggactaca atccgcttca tgaccaaggc tatccaagta ttggctgtgc 1543321 gccttgcact tctcccgctt ttacagcaga agatttgcgc tcaggcagat ggaatggtat 1543381 ggcgaaaaca gaatgcggac tgcatgaata aggagctgca aaatggaatt agccgctatt 1543441 ttatttagct tgtttttcgc gatgaatatt ggtgcaagcg gcgctgcagc ttcgatgggg 1543501 gttgcttacg gctccggagc catcaaaaag aaaacttacg ctttgatcct atgcgcagtc 1543561 ggtgtctttg ccggggcggt cattggcgga ggcgaggttg taaaaacaat cagctccggc 1543621 attattcctg agcagacgat tacactgacg attgtttgca tcattattgg agctgctgcc 1543681 ctgtcgctct ttactgctaa tctgctcggc attcctttgt cgacaagtga agtaacagtc 1543741 ggcgcggttg tcggcgtggg agtggcttat aaagtattgt ttgtgaacaa tcttctgatc 1543801 attgtgtcat tttgggtttt tgtcccgctg ttcgctttcg gcttcaccta tttcgtatct 1543861 aagctgtttc gttattttaa gattgaagta aaatcttcta aaaagcaaaa aatcctcggc 1543921 attgttttgt tagttgccgg atttttcgaa gcattctctg ccggcatgaa taacgtggcg 1543981 aatgctgttg gcccgttagt agctgccggt gtgcttgatg tcggaaaagg aaccttgtat 1544041 ggaggagctt ttgttgctct tggcgcactg ttattaggcc ggcgagtgct agaaacaaac 1544101 gggaagaaaa ttacgaggtt ctccaaaggg gaaggcattc tcttatccgg tacaggagcg 1544161 ggactggtga tcatcagttc tgtatttggg atgccggtgc ccttggcgca agtcacgtca 1544221 tcgtctatta tcggaatagg catggcgaaa aacggtccga acgtgttcca taaacaagtt 1544281 gttcaaacga tgctgaaggt atggatcgta tcgccgtttt tatctttatc gatttcttat 1544341 ctgcttgtat ccttgttttt aaaagcagat tattattcga tctttatcat ggtaagtgtg 1544401 cttttagcgg cgggcggtgc catcagcctg acaaaggcca ttcgtaaaga gagacgctca 1544461 gtccacgaac aaggcggggg aatctgatca ttaatctgag taattttata agttaactag 1544521 gaggagatgg atattatgag cttagcacca cacggaggaa cattagtaaa cagagtagat 1544581 gaatcatatg atgtgagcgg cattcaaaaa gaaattgaac ttgatttaat ttctttcgcg 1544641 gatttggaat tgatcggtat cggtgcatac agcccgattg aaggtttctt taatgaaaaa 1544701 gattacgtat cagtggtcga aaacatgcgt ctttcttccg gcgttgtctg gtctcttcca 1544761 atcacgcttc cggtcgatgc gcaaaaagca gcggaactgt cacttggtga aacggtaaag 1544821 ttaacgtatg aaggagaaac ttacggcgtt atccaaatcg aagacctgta cgtgcctgac 1544881 aaacaaaaag aagctgtcaa tgtgtacaaa acagatgaac aggagcatcc tggtgttaaa 1544941 aagctgttca gccgcggcaa tacatatgtc ggcggaccga ttacgttgat taaaaaagct 1545001 tcaaaacagt tccctgaatt tacatttgaa ccgtcagaaa cgagacgcca gtttgcggaa 1545061 aaaggctggg aaaccattgt cggtttccaa acaagaaacc ctgttcacag agcgcatgaa 1545121 tacattcaaa aaacggctct tgaaacagta gacggcttgt tcttgaatcc gttagtaggt 1545181 gaaacaaaat ctgatgacat tccagctgat gtacggatgg aaagctacca agtgcttctt 1545241 gatcattatt acccgaaaga tcgtgttttc cttggtgtct ttttagcggc gatgcgttat 1545301 gcaggcccga gagaagcaat tttccacgcg cttgtcagaa agaactacgg ctgcacacat 1545361 ttcatcgtcg gccgtgatca tgcaggtgta ggcgactatt acggaacata cgaagcacag 1545421 gaactgtttg acacatttaa acctgaagaa ctcggaatta caccgctgaa atttgagcac 1545481 agcttcttct gtaaaaaatg cggaaatatg ggaacagcaa aaacttgccc tcatggcaga 1545541 gagcatcacg tcattttatc aggcactaag gtaagaggta tgctgagaga cggtgtgctg 1545601 ccgcctgctg aattcagtcg aaaagaagta gtagaagtgt taatcaaagg gatgaagaaa 1545661 aaagaagaag taggcgtatc ttaaggagga ctggcagtga caaatcgcga tattgtatgg 1545721 catgaagcct ctatcacaaa agaagagtat cagcaaaaaa acaagcataa aagctccatt 1545781 ctctggctga cagggttaag cggctcaggc aaatcaacca ttgccaacgc cgctgcgaga 1545841 gaattgtttg agcaaggcta ccaagtcatt gtgctggacg gggataatat ccgtcacggc 1545901 ctaaataggg atcttggttt ttctgatgaa gaccgaaaag aaaacatccg ccggatcgga 1545961 gaggtggcga agctttttgt tcagcaggga accattgtga ttactgcttt tatctctcct 1546021 ttccgcgagg acagacaaca ggttcgcgag cttgtggaag cgggcgaatt taatgaagtc 1546081 tacattaaat gcgaccttga tatttgtgaa caaagagatc cgaaagggct ttacaaaaaa 1546141 gcaagaaacg gcgagattcc gttctttaca ggaattgatt ctccttatga agaaccggaa 1546201 gctccagagc tcgttcttga ttcaggacag catgaccgtg aagcgtgtaa aaatcagctg 1546261 atcgagtttg ttaaacaaaa attgagctga atatgatctg ctgcgttctt ctcagatgcc 1546321 ggaatgcaag cgagaacatc atcacagcga atcttctgga agaactcgaa tagatcgggg 1546381 gaaatacgat ggggaaagta tatattgtag gagcgggtcc cggtgaccct gatctgctga 1546441 caattaaagc gctgaaagcc attgaaaaag ctgatgtcat cttatatgac agattagtaa 1546501 ataaagagat tttacaatat gccaaagagc aagcagacct gatctactgc gggaagcttc 1546561 cggattttca tacgatgaag caggaaacca tcaatcgatt tcttgtgaag tatgcgcaaa 1546621 aagggaaaat ggttgtcaga ctgaaaggcg gagacccttt tgtgttcggg agaggagggg 1546681 aagaagcgga atgcctctct gaaaatggaa ttccgtttga aatcattccc ggcattacgt 1546741 ctggaatcgc ggcagccgct tatgccggga ttcctgttac ccatcgggat gcgggctcta 1546801 acgtcgcttt tgtaacgggt cactataaaa aagaagaaga ttttgaggaa aagtggaaag 1546861 cgctggctac aggaattgat acacttgtca tctatatggg tatcaaaaac gtgcagcaga 1546921 ttgaaagaaa actccttgaa aatggccggg acggttctac gccagcagcc tttattcatt 1546981 gggggacaac ggacaagcaa aaatctgttt tttgtacagt tgacaccctt tcagaaacgg 1547041 tgataaaaga aaacattaca aatccgagtt taattgtcat tggaaatgtt gtaaattatc 1547101 actataagct ggaatggttt gaatctgaac taaaaaaaca agatttaagc gaggcgttgt 1547161 aaaaatgaaa caagcaattt tatatgtcgg ccacggcagc cgggtcaaaa aagcgcagca 1547221 agaagccgca gcctttttgg aaggatgcaa ggcccacatc tctgtgccag tacaagaaat 1547281 cagcttttta gagcttcagg agccgacaat tgagacagga tttgaagcat gtgtgaagca 1547341 aggtgccact catatcgcag tggtgcctct gcttctttta acagctgcgc atgcaaaaca 1547401 tgatattccg gaagaaattg tccgtgttgc atctcgatat ccatcagtcc gtatttcata 1547461 cggaaagccg atcgggattg acgaagaagt agtcaaggct gtatatcacc gaatgaaaga 1547521 cataggtgtt ccgtatgaaa atgccagagt ggtgctcatc ggaaggggaa gttcagatcc 1547581 agacgtcaaa agagacgtaa ccggaattgc taatcttctt caggaaatgg ttccagtgaa 1547641 ggaagtcatt ccgtgctttt tgacagcatg cggccctaat tacaaagagg ttttttcaga 1547701 acttgaaaaa gatgacggca taacaacctt tatcgttcca tatttgcttt ttacgggtat 1547761 gctgatgaat gaaatcgaac gagaggttca gaaattaaaa gcccataatc cgaacgtcta 1547821 cctctcttcc tatatcggtt ttcatcctca tgtgaaaaac gcatttttga accgtgtgag 1547881 agaaactgcg gcaaattctg agggacaatt tgattttgat ggaggttcat atgcttccgc 1547941 tgcacattag cctggaaaag aagaaggttg tgattgcggg gggcggaagc atcgctctca 1548001 gaaggctgaa aacggtgatt tctgagggag ctgatataac gcttgtcagt ccggatgtgg 1548061 aaccggaaat caagcaaatg gcagaagagc ggcgtatcaa atgggaaaaa cggacaattg 1548121 aaaaagaaga ttatctcaat gctttcttca ttattgctgc gacggataat gcggcagtga 1548181 acaaagaaat tgcccaatcc gcttcgcctt ttcagcttgt caattgtgtc agtgacgctg 1548241 agcttggcaa tgtatatatg ccgaaaatcg taaaaagagg gcatgtcact gtgtctgttt 1548301 ctacaagcgg agccagtcca aagcacacga aagagcttgc tgaaaacgtg gataagctga 1548361 ttgacggcga ttttgttgct gaagtgaaca ggctttatca gatgagaaga aagaaataag 1548421 ccagagcata caaatgctct ggcttttctt tatgcggctc agcttttttt gagcttgatg 1548481 acagtatcag catcaggcgt gacaaagacg gtatgctggc tgtcataagt gacgaaaccg 1548541 ggtttcgcgc cgtttggttt tttgacatgc ctgatttttg tataatctac aggcactgaa 1548601 cttgaatctt tagcttttga aaaataagct gcaattgtcg cggcttccat gattgtttgc 1548661 tcatcaggtt cgctgcttct gatcacaacg tgggagccgg gaatgtcctt cgtgtgaagc 1548721 cagatatcgt ctctggccgc cactcttgtc gttaaatatt cattttgacg attgttctta 1548781 cccactaaaa ttgtcagccc tgaggtggat tcatatgttt ctaacaccgg attgtgcggt 1548841 ttttgctttt tctggccttt ttgctgctta gggcgtaaat atttgccctc aacaagctct 1548901 tccctgattt cgctgatatc ccggggagaa gcggacgaaa gctgctgaat cagctgatca 1548961 aaatattcga tctcttcctg tgccagcctg atttgctcct cgacaactgc gaccgaattt 1549021 ttcgctttct gatacttcgt gaaataggcc tgtgcgtttt cagaaggcgt tttgttcggg 1549081 tttaaaggaa tcgtgattgt cgggctttct tcatcataat aattgatgac ctcagcctgt 1549141 ttatcacctt ttttcagcat atataaatta gcggttaaaa gctctccgta aagctgaaat 1549201 tccttcgcgt tttccgaata ctccagggtt ttctctaatt ttttgatttt gttggcattc 1549261 ttcttccgtt cgttcacaac aaaacgctca agatcctgag cctgttgctt aacccggtct 1549321 cgttcagctt ttccgaaata aaaacggtcg agcagttcgc ttaatgaatc aaaacggcgc 1549381 gcttcgccct ttagatgagt cagctccagc agataaaaat attcctttcc gtttacagtc 1549441 gtaatgttgg gaatgaaacg gtgctctttc acttcggcaa acagtgccag caacgctttt 1549501 ggcagtgtga ctttgttggc aaggcctgct ctgtgaaccg cttctttggc gaaaagcgga 1549561 gacacgcctg aaaagtggtc gacaatttgt ttatcaagcc ttccttcttg aaagctgagg 1549621 tgacgcaaaa tatcatcttc tgacgcctca agaggcgata ttttgtcctg agcaggcgga 1549681 agcttataat cttggccggg cagtactgta cggtagctgt tcattgacgg tgataaatgc 1549741 ttaagtccgt cgataatcac attttctgct gcgtcagtca aaatgatatt gctgtggcgg 1549801 cccataattt ctacataaag ctttcgtacg gtttcatcgc caatttcgtt tcggcttttg 1549861 atatgaaaaa tcataatgcg gtctaagccc gcttgttcaa ttttctcaat gaatccgcct 1549921 tcgatatgct ttctcagcaa catgcaaaac attggcggtt cgcttggatt ttcataagct 1549981 tgtgccgtga tatgcacccg tgaatagctc ggatgtgccg ataataatag tttttggttt 1550041 tttcccttgg cacggatgtg gaaaatcaca tcgtgcttat atggctgatg gatttttgta 1550101 attcgtccgc ccattatttt ctcgttaagt tcgtgtgtca ttccgtatgt aaacatgcca 1550161 tcaaacgaca tatgcaatac accctctcat tcttcctgca ttcgataatt atagcatgaa 1550221 atgggacgag tcagaataag catgcttata gagtgatatc tctataagag agcaggggag 1550281 tggacgagcg gaatgaagtt tcatgaaatg ggacaaacag atttactaga ggcaaccaat 1550341 acgtccatga aacaaggatt aacagaaaaa gaggtaaaaa aacgccttga caagcatgga 1550401 ccaaacgagc tgcaagaagg gaaaaaaact tcagcgcttc tcttgttttt cgcgcagttc 1550461 aaagatttta tggtgcttgt gcttctggcg gcaacgttaa tctcaggatt tcttggtgaa 1550521 tatgtagatg cggttgcgat tattgcgatt gtgtttgtga atggcatact cggtttcttt 1550581 caagaaaggc gtgctgagca atctcttcag gctttaaaag agctttcaac accgcacgtc 1550641 atggcactca gggaaggaag ctggacaaag attccttcta aggaactggt gccgggtgat 1550701 attgtgaaat ttacgagcgg ggacagaatt ggcgcagacg ttcgaattgt tgaagcgaga 1550761 agccttgaaa tagaagaatc agcgctaacc ggggaatcaa tcccggttgt gaagcatgct 1550821 gataaattga aaaaaccgga tgtttcactc ggcgatatta ccaatatggc atttatgggt 1550881 acgattgtga cccgcggcag cggtgtcggg gttgtcgtcg ggacaggaat gaatacggct 1550941 atggggaaaa ttgccgacat gcttgaatcg gcagggacat tgtcaacccc gctgcaaaga 1551001 agactggagc agctcgggaa gattttgatt gttgttgcat tgcttctgac cgtacttgtc 1551061 gttgctgtcg gtgttattca gggtcatgat ctgtacagta tgtttttagc aggtgtctcg 1551121 ttagcggtag ccgctattcc ggaggggctg ccggcgattg tgacagtggc gctttcgctt 1551181 ggtgtacaga ggatgattaa acaaaaatcc attgttagaa agcttcctgc tgttgaaacg 1551241 cttgggtgtg cgtctatcat ttgctcagat aaaacaggga caatgaccca aaacaaaatg 1551301 acagtgacgc atgtctggtc cggagggaaa acatggagag tggcaggggc cggctatgaa 1551361 ccgaaaggaa gcttcacact aaacgaaaaa gagatcagtg tcaatgaaca taagccgctt 1551421 cagcagatgc ttctgttcgg agcgctttgt aacaactcca atattgagaa aagagacggc 1551481 gaatatgtgc ttgacggaga tccgacagag ggagcgctgc tcaccgcggc aagaaaaggc 1551541 ggtttttcaa aggagtttgt tgaatctaat tacagagtga ttgaagaatt tccgtttgat 1551601 tccgcacgga aaatgatgac tgtcatcgta gagaatcaag acagaaagcg ctatatcatt 1551661 acaaaaggtg cgccggatgt actcatgcag cgatcttccc gtatttatta tgatggctca 1551721 gcggctcttt tttcaaatga aagaaaagca gaaacagagg cggtattaag acatttggca 1551781 tcacaggcgc tcagaacgat agcggtcgcc tacaggccga taaaagcagg cgaaacaccg 1551841 tcaatggagc aggcggaaaa agatctgacc atgcttggcc tttcaggtat cattgatccc 1551901 ccgcggccgg aagtcagaca ggcgattaaa gaatgccgtg aagcgggaat taagaccgtc 1551961 atgattacag gtgatcatgt agaaaccgct aaagcgatag cgaaagactt gcgcctcctt 1552021 ccgaaaagcg gcaaaatcat ggacggcaag atgctgaatg aactttctca agaagagctt 1552081 tctcatgtgg tggaggatgt gtatgtattt gcccgcgttt cccctgaaca taaactaaaa 1552141 atcgtaaaag cctatcagga gaacgggcat attgtggcga tgacgggaga cggcgtcaat 1552201 gatgctcctg ccattaaaca ggctgatatc ggcgtctcta tgggcattac cgggacagat 1552261 gtggccaaag aagcatcatc tcttgttctc gtggatgata attttgcgac gattaaatca 1552321 gcgataaaag aaggcaggaa catctacgaa aatatcagga agtttatcag atacctgttg 1552381 gcgtctaacg tcggagaaat ccttgtcatg ctgtttgcga tgctgcttgc ccttccttta 1552441 ccgctggttc cgattcagat tttgtgggtc aacttggtga cggacggatt gccggcaatg 1552501 gcgctcggca tggatcagcc ggaaggagac gtcatgaagc gcaagccccg tcatccgaaa 1552561 gaaggggtat ttgcccgcaa gctaggatgg aaggtcgttt ccagaggatt tttaatcgga 1552621 gttgccacta ttttagcgtt tatcattgtg taccaccgca atccggaaaa cttggcttat 1552681 gcccagacga tcgcgtttgc cacattggtg ctcgctcagc ttattcacgt gtttgactgc 1552741 cgcagcgaaa cttctgtttt ctctagaaat ccgtttcaaa acctgtattt aatcggcgcg 1552801 gtattgtcat ccattttgct gatgcttgta gtaatctact atccgccgct tcagccgatt 1552861 ttccatactg tagccatcac gccgggggac tggatgctcg tcatcggtat gtccgccatc 1552921 cctacttttt tgctggcggg gtcactttta acaagaaaaa aataaattca tatgatataa 1552981 tcttaggggt aatagcgtgt ctattgccct tttattatga gaacagggaa gaattgggtg 1553041 ttttaaaatg atacgaagta tgacaggctt cggcagtgca agcaaaacac aagacgatct 1553101 ctctgtaagc gttgaactta aatctgtgaa ctacagattt aaagaagtga acgctcgttt 1553161 gccaaggcct ttgctatatt ttgaagataa gctgaaacag accattctgc agcatattca 1553221 gcgcggaaga attgagcttt tcgtatccgt tgacagcgat atgcttgttg agaaaaggct 1553281 tgaaattgat tggccgctgc tcgatgagtt tgtcgcagcc gcgagagata tgaagaagcg 1553341 gtatcaattg tctgcagagc ccgatgtaat ggatttcttt aagcttgatc atgtcgtcca 1553401 ggttcatgaa gaacagacgc aaaatgacaa gctggaggcg ttgatcatcg atgctgcaga 1553461 agaagcggta aaaggtctct gtgaaatgcg tgaaaaagag gggctgctct tagcgaaaga 1553521 ctgcctgatg catattgatc agcttgaaga gctggtgaga gaaactgaat tgctggctgc 1553581 agatgtcgta tctcgttacc gggaacggct gtatgccaga atcaaagaat ggactgaaga 1553641 cgtattagac gagagccggc ttgtaacaga atgcgctatt tttgcagacc gctctgatat 1553701 cactgaagag attacaaggc tgaagagcca cttcgcccag tttcgtgata tattagctag 1553761 tggcggagct gtcgggcgca aactcgactt tcttgttcag gagctcaatc gggaagcaaa 1553821 tacgatcggc tcaaaagcaa atgatcatca gatcacaaag cttgtcgttg aaatgaaaag 1553881 ttctattgaa aaaataaaag aacaagtgca aaatatagaa tagtgactgt gcgtattgtt 1553941 tacagacggt cttactaggc taaactagag acgtctattt tacaggggga acgtagaaga 1554001 tgacgattaa actgattaat atcggatttg gcaatatcat ctccgccaat cggatgattt 1554061 cgattgtcag cccggagtct gcgccaatca aacggatgat tcaggatgca agagaccgcg 1554121 gaatgctaat tgacgctaca tacggacgaa gaacccgtgc agttgtcgtc atggatagtg 1554181 atcacattat cttatctgcc gtccagcctg agacagttgc acacagactt tctgttaaag 1554241 aagaaattat ggatgaaggg caggggtaat tgccgcatga aagaaagagg gttattaatc 1554301 gttctctcag gtccctcagg agttggtaaa ggaacggttc gacaagcgat cttttcgcag 1554361 gaagacacaa aatttgaata ttcgatttca gtaaccacaa gaagtccaag agagggcgaa 1554421 gtgaacggag tcgattattt tttcaaaaca agagacgaat tcgagcaaat gattgcggac 1554481 aacaagctgc ttgaatgggc agagtatgtc ggcaattatt acggcacgcc agtcgattat 1554541 gttgaacaga cgcttcaaga tggaaaagac gtctttttag aaattgaagt tcaaggggct 1554601 cttcaagtga gaaatgcttt cccggaaggc ctgtttattt tccttgcgcc tccaagcctt 1554661 tctgaactga aaaacagaat cgtgacacga ggaacagaaa cagacgctct gattgaaaat 1554721 cgaatgaaag ccgcaaaagc tgagatcgaa atgatggatg cttatgacta tgtcgttgaa 1554781 aacgataatg tcgaaacggc ttgcgataaa atcaaagcaa tcgttcttgc tgaacatttg 1554841 aagcgtgaac gcgttgcacc aagatataag aaaatgctgg aggttgaata atcaatgtta 1554901 gatccgtcaa ttgattcttt aatgaataaa ttagattcaa aatatacgct ggtgactgtt 1554961 tctgcgagac gtgcccgtga aatgcaaatc aaaaaagacc aaatgattga acatacgatt 1555021 tcacacaaat atgtaggcaa agctttagaa gaaattgatg caggcctgct ttcgtttgaa 1555081 aaggaagacc gcgaatagta gcacaagtag caacctatat catgtaggtt gttatttttt 1555141 tccgtgcggt tttgtaaagt gcagaggggg agaattcatt gcttaacaat cgaaatgtgt 1555201 tactttgcgt gagtggaggc atcgctgttt ataaagcctg tgcgttaacg agcaagctgg 1555261 ttcaggcagg agcaaatgtc aaagtgatta tgactgaatc cgcttgccga ttcgtttcac 1555321 cgctgacatt tcaggcattg agccgccacg aagtctatac agatacattt aaagaacaaa 1555381 atccaagcgt catttctcat attgatgccg cagactgggc cgacttgatt atcgtagcgc 1555441 cggctacggc taatgtgatt ggaaaactgg caaacggcat cgctgatgat atgctgacga 1555501 caacattgtt ggcagcaacg gctcccgttt ggatcgcgcc ggcaatgaac gttcatatgt 1555561 atgaccaccc ggcagtcaaa cgaaacattt ctgttcttta tcaggacggt tattgtttta 1555621 ttgagccaag tgagggctat ttagcatgcg gttacgtagg aaaaggcaga ttggaagagc 1555681 cggaaaacat cgtaaagctg gccgaaaaac attttgctga agaaacatcc gctcctttag 1555741 aaggcaagca tgtggtcatt acagccggcc caacgcggga agcgattgat cctgtccggt 1555801 tttttaccaa taaatcgacg ggcaaaatgg gctacgcact ggcggaggct gctgttcagc 1555861 tcggcgcacg ggtaatctta atttctgggc ctgtttcact tgatcagcct aaaggccttg 1555921 ctgagtttat ccctgttcaa tcggctgcgg atatgcgcga agctgtgctc tctgtgtatg 1555981 acgcaagcga tatagtcatt aaaacagctg cggtagccga ttttacgccg aaaacagtat 1556041 ttgaccataa aatgaaaaaa caagacggcg gcatgacctt agaactgaaa agaacagtcg 1556101 atattttgaa agaattgggc gagaaaaaga aagagcagat tttggtcgga tttgccgccg 1556161 aaacacaaga cattgaacac tatgcacgta aaaagctcgc cgctaaaaac cttgatttga 1556221 ttgtggcaaa tgatgtgaaa gcaaatgggg ccggttttgg tgctgatacg aatatcgtga 1556281 caatcttttt caaagacggg cataaacgcg aactcccgat tatgtctaag ctcgatgttt 1556341 cttttgaaat ccttcaggag atcgcagccc tctcaaaaca aaccggagag cgctcatgaa 1556401 ttttgcagaa gtcatcgttg atgtcagcac caaaaatata gacaggcctt ttgattataa 1556461 aatcccagac catctgaagg gcatgatcaa aacggggatg cgggtcattg ttccgtttgg 1556521 cccccgtaag attcaagggt ttgtgacagc agtcaaagaa gcatctgacc tatcgggaaa 1556581 atctgtcaag gaagtagagg atttattaga tcttacacct gttctgacag aggagcttat 1556641 gattctgtca tcatggctgt cagacaaaac gctgtctttt aaaataacgg cgcttcaagc 1556701 aatgctgcct gccgccttaa aggcgaaata tgaaaaagaa ttaaaaattg cacacggagc 1556761 cgatcttccg ccgcaagtgg aacggctgtt ttctgaaaca aagacgctgc tgtattcaga 1556821 tatacccgat catgagacgc tgaaactgat tcaaaggcat gttcaaaaag gggacattga 1556881 cgtgacgtat aaagtcgcgc aaaaaaccaa taaaaaaatg gtcaggcata ttcaggcaaa 1556941 tgcgagtaaa gaagagcttg ctaagcaggc tgagggattg tcccgccaag cagcaaaaca 1557001 gcaggcgatt cttcactttc tcatctctga gccggaaggt gtgaaaattc ctgcggcgga 1557061 attgtgcaaa aaaacggaca cgagctctgc aaccatcaaa acccttatcc aaaaagggct 1557121 tttgaaggaa agctatgaag aggtttacag agatccctat caggacaaaa tgttcaaaaa 1557181 aacagagccc ctgccgctga cagacgaaca gagggctgcc ttcgagccca tacgcgagac 1557241 attggacagc gatgagcata aagtgttcct ccttcacggc gtgacaggaa gcggaaaaac 1557301 cgaaatttat ctgcaatcaa ttgaaaaagt actggcgaaa ggaaaagaag ccatcgtcct 1557361 cgtaccggaa atatcgctga cgccgcaaat ggtcaaccgc ttcaagggcc gcttcggctc 1557421 ccaggtggca gtcatgcaca gcggtttatc cacaggagaa aaatatgacg agtggcgtaa 1557481 aatccaccgg aaggaagtac ggcttgtcgt cggtgccaga tccgccattt ttgctccgtt 1557541 tgaaaatctc ggaatgataa tcatcgatga agagcacgag tcttcctata aacaggaaga 1557601 aatgccgcgc tatcatgcga aagaggtggc aatcaagcgg gctgagcatc acagctgccc 1557661 ggttgtatta gggagtgcta cgccgacatt agaatcatat gctagagcgc aaaagggcgt 1557721 atacgagctt ctttcactga agcaccgtgt taaccatcgg gtgatgcccg aggtttcgct 1557781 tgtcgatatg agagaggagc ttagaaacgg caatcgctcg atgttttcag ttgaattgat 1557841 ggaaaagctt gaagaaacga ttgccaaggg tgagcaggcg gtgctgtttt taaataagag 1557901 gggctactct tcctttgtga tgtgcaggga ttgcggctat gtcccgcaat gcccgcactg 1557961 cgacatttcc atgacgtatc atcgttacgg ccaaaggctg aaatgccatt attgcggaca 1558021 tgaagagcct gttccgcaca cttgtcctga atgcgcaagc gagcatatcc gctttttcgg 1558081 aacgggaaca cagcgagtgg aggaagagct gacaaaagtg ctgccaagtg cgagagtgat 1558141 tcggatggat gttgacacga catcacggaa aggcgcccat gaaaaattac tgtcagcttt 1558201 cggagaagga aaagcggata ttcttctcgg aacgcaaatg atcgcgaaag ggcttgattt 1558261 tccgaatgtc acgcttgtcg gagtgttaag tgctgataca acacttcata ttcctgattt 1558321 cagatcggct gaaaaaacat ttcagctgtt aacgcaagtc agcggccggg caggcaggca 1558381 tgaaaagccc ggccatgtca tcattcaaac gtatacaccg tctcattaca gtatccagct 1558441 gacgaaaaca cacgattatg aaacgttcta tcagcatgaa atggcgcaca ggagagagca 1558501 atcctatccg ccatactact atttggctct tgtgactgtt tctcatgagg aagtggcgaa 1558561 agcagcggtt acagctgaaa aaatcgctca ttttttgaaa gcaaactgcg gagctgacac 1558621 gaaaattctc ggaccaagcg cgtcgccgat agccaggatc aaagatagat atcgctatca 1558681 atgcgtgata aaatacaaac aggaaaccca gttatccgct ttattgaaga agatactgga 1558741 acattataaa cgcgaaattg aacaaaaaca tgtaatgatt tcaattgata tgaatcctta 1558801 tatgatgatg taagatctca cgtcttggag ggtaacaaat tggcagtaaa aaaggtcgtc 1558861 acacatcctg cggaggtttt ggaaacacct gcggaaaccg tgactgtttt tgataaaaag 1558921 ctaaaaaaac tgcttgatga tatgtacgac accatgcttg aaatggatgg tgtcggactg 1558981 gcagcgccgc aaatcggcat tttaaaaaga gcggccgtcg tagaaatcgg ggatgacaga 1559041 gggagaattg atctcgttaa tcctgaaatt ttagaaaaaa gcggcgagca aaccggaatt 1559101 gaaggatgct tgagctttcc taacgtctat ggtgatgtca cacgtgccga ttatgtcaaa 1559161 gtgcgtgcgt ttaaccgtca gggaaaaccg ttcattctgg aagcgcgagg ctttttagca 1559221 agagccgtgc agcatgaaat ggaccactta gacggtgtgc tgtttacatc taaaataagt 1559281 aaatactata cagaagatga actagcggat atggaaggat gatttgatga cgagaatcgt 1559341 atttatggga acgccggatt tttcagttcc tgttttaaga accctgatag aggacggata 1559401 tgaagtagtg ggggtcgtca cacagccgga ccgtccgaag ggcagaaaaa aagtactgac 1559461 acctcctccg gtaaaggaag aggcattgcg ccacggcatc ccggttcttc agccggaaaa 1559521 agtcagattg acagaagaaa ttgaaaaagt gctggcatta aagcctgacc tgattgtaac 1559581 ggcggcattc ggacaaattt tgcctaaaga gcttctcgac agtccaaaat acggctgcat 1559641 taacgttcac gcatcccttt tgccggaact gcgcggcggt gctccgatcc attattccat 1559701 tctgcaggga aagaagaaaa ccgggattac cattatgtat atggtagaaa aattggatgc 1559761 gggcgatatg atctcaaaag tggaagtgga cattgaagaa accgacaatg tcggaacact 1559821 gcacgataaa ttaagcgttg ctggcgcgaa gctattgtct gaaacggttc caaacgttat 1559881 tgccggcagc atatcacctg aaaagcagga tgaagagaaa gcgacgtacg cgcctaacat 1559941 taaaagagag caagagctgc tcgactggtc cagaacgggc gaagagcttt acaaccagat 1560001 ccgcggctta aatccatggc ctgttgctta tacgactcta aacggacaaa acttgaaaat 1560061 atgggcgtcg aaaaaaatag cggcaccaac aacagctgag cccggcacag tcgttgcagt 1560121 tgaaaaggaa ggaattatcg ttgccacagg taacgagacg gctctgttat taaccgaact 1560181 ccagccggca ggcaaaaaac gaatgaaagg cgaagacttt gtgcgaggcg ctcatgttga 1560241 agccggtgat gtgttaggag taaacaatga aaaaaactag tgttcgtgac atcgcccttg 1560301 aggcgctgat caaattagaa caaaaccagg catacagcaa cctgctgctg aaatcggtca 1560361 ttaaatcaaa tgaactgagt gatcagaaca gagggctttt gactgaactt gtctatggta 1560421 cattacaaaa taagatcgcg cttgattata tgcttaaacc gtttatcaat aagcctcaaa 1560481 aggtaaagcc gtgggtgatt cagcttcttc gcctatcctt atatcaaatg gagtatttgg 1560541 agaagattcc agacagggca gccattcatg aagcggttga gattgctaaa atccgcggac 1560601 acaaaggcat tgcttcattt gtcaacggcg tgctccgttc tattcagcgc gaaggtgttc 1560661 catcctttga cgcgatcgaa gatcctgtcc gccggctggc gacagaaaca agccatccgg 1560721 aatggcttgt gaaagagtgg gcggatgcgt atggatttga agctgcggaa aagatttgcc 1560781 gcatccatct cattccgccg aaacagacgc tgcgtgtcaa tcaaatgaaa gcagacagag 1560841 ctgagctgct tgaccaaatg gctgctgagg gaatcgaagt tgaaaaaggc gacctcgctg 1560901 aagatgctgt gaagctctta aagggaacaa ttgccggaac tcatttcttc caaaacggcg 1560961 aagtttctat ccaggatgag agctccatgc tcgtcgcccg cgcccttgat cctaagtcag 1561021 atgaaacagt gcttgacgcg tgtgcggcgc ctggcggaaa gtcggctcat atcgcagaat 1561081 taatgaagaa caaggggagc gttacgtcgc ttgatcttca caaacataaa gtgaagctga 1561141 tcaaagaagc ggcagatcgg cttggcctga caatcattca tgcggaaaca atggatgcta 1561201 gaaaagcggg ggaaacgttt gaaaacgaac agtttgaccg aatattggtc gatgccccgt 1561261 gctcaggttt cggtgttatc agaagaaagc cggacatgaa atacacgaaa aaacctgacg 1561321 acagcgcccg tctagctgaa atccagctgt cgatcttgag ggaaatcgca ccattagtaa 1561381 aaaaaggtgg cactcttgtc tacagtacgt gtacaatgga ccggacagaa aatgatgaag 1561441 taatacatgc gtttatacaa gaacatcctg attttgaacc cgatttgtct cttgaaaagc 1561501 ggctgcctga aaaggtgaga ccctttgttc gggatggaag gcttcaaatc cttcctcatt 1561561 atttcggaac agatggtttc tttatttgca gcatgagaaa gaagggataa gcaatggcag 1561621 aacttaataa aacaaaagta agaaaagaat tgcggacaga gcgtccgtct atttattctt 1561681 ttgaattaga tgaaatcaaa caatggctga cagacaatgg agagaaaccg ttccgtgcag 1561741 cccagatctt tgaatggcta tatgaaaaac gcgtatcttc ttttgaagat atgacaaacc 1561801 tctcaaagga tctgcgtgag aaattaaaca ctcgctttgt gttaacaacg ctgaaaacgg 1561861 ctgttaaaca aacctctcaa gacggtacga tgaagttttt gtttgagctt catgacggtt 1561921 ataccatcga aaccgtttta atgagacacg agtatggcaa ttctgtatgt gtaacgacac 1561981 aagtcggctg ccgtattggc tgcacattct gcgcgtcaac gcttggaggc ttaaaacgaa 1562041 accttgaagc aggggaaatt gtcgctcaag tagtcaaagt gcaaaaagct cttgatgaaa 1562101 cggatgaacg cgtcagctct gtcgtgatca tgggaatcgg cgaacctttt gataacttta 1562161 acgaaatgct cgctttcttg aaaatcatta accatgacaa gggcctgaat atcggtgctc 1562221 gccatattac ggtctctacg agtggaatca tcccgaaaat ttacgaattt gctgatcagc 1562281 aaatgcagat taactttgca atttctctgc acgcgccgaa cacagaaatc agaagccgtt 1562341 tgatgccgat taacagagca tataaactgc ctgatctaat ggaagccgtt aaatattata 1562401 ttaataaaac aggacgccgt atcagctttg aatacgggct gttcggaggc gtaaacgacc 1562461 aggtggaaca cgccgaagag cttgccgact tgctggaagg agtcaaatgc cacgtgaact 1562521 tgattccggt aaactacgtg cctgaacggg actatgtgcg cacaccgcgt gatcagattt 1562581 ttgcttttga aaaaacgctg aaatcccgcg gagtaaatgt cacaatccga agagagcaag 1562641 gacatgacat tgacgcagcc tgcggtcagc ttcgcgcgaa ggagcgtcaa gacgagacga 1562701 ggtgatgagg gttgttaaca gccttaaaaa cagatacagg aaaaatccgc cagcataatg 1562761 aagatgatgc ggggatattc aaggggaaag atgaatttat attagcggtt gtcgctgatg 1562821 gcatgggcgg ccatcttgct ggagatgttg cgagcaagat ggctgtgaaa gccatggggg 1562881 agaaatggaa tgaagcagag acgattccaa ctgcgccctc ggaatgtgaa aaatggctca 1562941 ttgaacagat tctatcggta aacagcaaaa tatacgatca cgctcaagcc cacgaagaat 1563001 gccaaggcat ggggacgacg attgtatgtg cactttttac ggggaaaacg gtttctgttg 1563061 cccatatcgg agacagcaga tgctatttgc ttcaggacga tgatttcgtt caagtgacag 1563121 aagaccattc gcttgtaaat gaactggttc gcactggaga gatttccaga gaagacgctg 1563181 aacatcatcc gcgaaaaaat gtgttgacga aggcgcttgg aacagaccag ttagtcagta 1563241 ttgacacccg ttcctttgat atagaacccg gagacaaact gcttctatgt tctgacggac 1563301 tgacaaataa agtggaaggc actgagttaa aagacatcct gcaaagcgat tcagctcctc 1563361 aggaaaaagt aaacctgctt gtggacaaag ccaatcagaa tggcggagaa gacaacatta 1563421 cagcagtttt gcttgagctt gctttacaag ttgaagaggg tgaagatcag tgctaatcgg 1563481 caagcggatc agcgggcgtt accaaattct ccgcgtcata ggcggcgggg gaatggccaa 1563541 cgtgtattta gctgaggata tcattctaga ccgtgaagtc gcaattaaaa tcctgcggtt 1563601 tgactatgca aatgacaatg aatttatcag acgtttccgc agagaagccc aatccgcatc 1563661 aagcctcgat cacccgaata ttgtcagcat ttatgatttg ggcgaggaag atgatattta 1563721 ttatattgtc atggaatacg ttgaaggcat gacgcttaaa gaatacataa cagcaaatgg 1563781 gccgcttcac cctaaagaag cgctgaacat catggagcaa attgtctcag ccatcgctca 1563841 tgcccatcaa aaccagattg ttcacagaga catcaagccg cataacattt tgattgatca 1563901 tatgggaaat atcaaagtaa cggattttgg aattgcgacg gcactaagtt cgaccacaat 1563961 cacccatacc aattcagttc tgggctcggt ccattactta tcacctgaac aggcccgggg 1564021 cggcttagcc acaaaaaaat cggatattta tgcgcttgga atcgttctat ttgagctttt 1564081 aaccggccgt attccgtttg atggagagtc agcagtcagc atcgccttga agcatcttca 1564141 agcggaaact ccttcggcaa aaaggtggaa tccatcggtc ccccaaagcg ttgaaaacat 1564201 catactcaag gcaactgcca aagatccttt tcatcgctac gaaacggctg aagacatgga 1564261 agcagacata aaaacagctt ttgatgccga cagactcaat gaaaagagat ttacgattca 1564321 agaagatgaa gaaatgacaa aagcgatacc tatcattaaa gatgaagaac ttgctaaagc 1564381 tgctggcgaa aaagaagctg aagtgacaac cgcacaagaa aacaaaacaa agaagaacgg 1564441 caaaagaaaa aagtggccgt gggttttgct cacgatatgc ctcgttttta tcacagctgg 1564501 aattcttgct gtcactgttt ttccgtcgct tttcatgcct aaggatgtca aaatacctga 1564561 tgtctccgga atggaatacg aaaaagccgc agggctcttg gaaaaagaag gtttacaggt 1564621 tgattccgag gtgttggaaa tctcagatga aaaaattgaa gagggcctga tggtaaaaac 1564681 ggatcctaaa gcggatacca cagtcaaaga aggcgccacg gtcacccttt ataagagcac 1564741 cggaaaagca aaaacggaga tcggtgatgt gacaggccaa acggtcgacc aagcaaaaaa 1564801 agcgttgaag gaccaagggt ttaatcatgt aacagtaaat gaagtgaatg acgagaaaaa 1564861 tgcgggcact gtcattgacc aaaatccttc agcagggact gagctggtcc cgagtgaaga 1564921 tcaagtcaaa cttacagtca gtatcggacc cgaagacatt acgcttagag acttgaaaac 1564981 ctacagtaaa gaagcagcgt ctggatatct ggaagacaac ggattgaagc ttgtagaaaa 1565041 agaagcatac tcagatgatg ttccagaagg acaggttgtc aaacaaaaac cagcagcagg 1565101 tacggcagta aagccgggaa acgaagttga agtgacattc tctctcggac cagagaaaaa 1565161 acctgcgaaa acagtgaaag aaaaggtcaa gatcccctac gaaccagaaa atgaagggga 1565221 cgagcttcaa gtgcaaatcg cggttgacga tgcggatcac agcatctctg acacttacga 1565281 agaatttaag ataaaagagc cgactgaacg aacgatcgaa ctaaagattg aaccaggcca 1565341 aaaagggtac tatcaagtaa tggtaaacaa taaagttgtc agctacaaaa ccattgagta 1565401 tccgaaagat gaataacaag gagggaaaat atgcctgagg gcaaaattat taaggcgcta 1565461 agcggctttt actatgtact ggatgaatca gaggattcag ataaagtaat acaatgcaga 1565521 ggaagaggca ttttcagaaa aaacaaaatt acccctcttg tcggtgatta cgttgtgtat 1565581 caagctgaaa atgacaaaga aggatatcta atggaaatta aagaaagaac caacgagctt 1565641 atcaggccgc caatttgcaa cgttgatcaa gcggtccttg ttttctcagc ggttcagcct 1565701 tctttcagca cggcattgct cgaccgcttc ctggttctcg ttgaggccaa tgatattcag 1565761 ccgattatat gcattactaa aatggatctg attgaagatc aagatacaga agatacgata 1565821 caagcctatg cagaagacta tcggaatatt ggttatgacg tataccttac ctcctctaag 1565881 gaccaagata gtttagcgga catcatcccg cattttcagg ataaaacaac ggtatttgcc 1565941 ggtcagtccg gtgttgggaa atcctcgctt ctcaacgcga tcagtccgga gctcggatta 1566001 agaacaaacg agatttccga gcatttgggc cgcgggaaac acacaacccg ccacgtggag 1566061 ctgattcaca cgtccggagg tttggttgca gatacaccgg gattcagctc gcttgaattt 1566121 acagacattg aggaagaaga gctgggctat accttccctg atatcagaga aaaaagctct 1566181 tcatgcaaat ttagaggctg tttacatctg aaagagccga aatgtgcggt gaaacaagct 1566241 gttgaagacg gggaattaaa gcagtatcgc tatgaccatt atgttgaatt tatgacggag 1566301 attaaagaca gaaagccgag gtattagcat aatgataaag gttgcaccat ctattctttc 1566361 cgctgatttt gccgctttag gcaatgagat taaagatgta gaaaaaggcg gagccgattg 1566421 tattcatatt gatgttatgg acggccattt tgtcccgaat atcacaatcg gtccgctgat 1566481 tgtagaagcg gtccggccgg taacggatct gccgcttgat gtccatttaa tgatagaaga 1566541 gccggatcgt tatatcccgg cttttgcgaa agcaggcgca gatatcctgt ctgtgcatgc 1566601 tgaggcatgt ccgcacctgc accgtaccat ccagctcatt aaagagcaag gagtgaaggc 1566661 cggagtagtt ctaaacccgc atacccctgt acaagtcatc gaacatgttt tcgacgatct 1566721 tgatcttgtt cttttaatga cggtgaaccc gggcttcggc gggcagaaat ttattcattc 1566781 agtccttcct aaaataaaag aggttaagcg aatggcggat gaaaaaggaa aaaaagatct 1566841 gttaattgaa gtagacggcg gcgtcaacaa agaaaccgct ccgctcgtca ttgaagcggg 1566901 cgcaaattta ctcgttgccg gttcagctgt ttatggccag tctgaccgca aaaaagcaat 1566961 ttctgaaatc agaggaagta aataagcagc tttagaaaag agctgggcat acaatagcct 1567021 aagctctttt tcctgtatgc agagaaagga atcagagatg aaaacaatta atatcgttgc 1567081 gggaggcccg aaaaatctca ttcccgatct aaccggctat acggatgaac acacgctttg 1567141 gatcggtgtt gacaaaggca ccgtcactct cttagatgcc gggatcattc ctgttgaagc 1567201 cttcggagat tttgacagca taacggagca agaacgccgg cgaatagaaa aagccgctcc 1567261 cgcccttcat gtgtatcaag cagaaaaaga tcaaacagat ttagacctcg cccttgattg 1567321 ggcgctggaa aagcagccgg atattattca gattttcggc attacaggcg gcagagctga 1567381 tcatttttta ggaaacattc agcttctgta taaaggtgta aaaacgaaca taaaaattag 1567441 gctgatagac aaacaaaatc atattcaaat gttccctcct ggtgaatatg atattgagaa 1567501 ggatgaaaat aagcgatata tctccttcat accgttttcc gaagacatac atgagctgac 1567561 cctgaccggt tttaaatatc ctctaaataa ttgtcatatt acgctcggtt caacactatg 1567621 tattagtaac gaactcattc attcacgagg tactttttcg tttgcaaaag gcatattaat 1567681 aatgataaga agcacggatt aagcatgtgc tttcattcaa ttgctgaaaa caatgaacaa 1567741 ggcggttacg ggacgttata ggaggggaca aaaatgaaat tttacaccat taaattgccg 1567801 aagtttttag gaggaattgt ccgggcgatg ctgggctcat ttagaaaaga ttaatgccca 1567861 ggggttcaaa gccctctttc accacataaa aacgcctgcc acatatcggg gcaggcgttc 1567921 attttgttat acacgctcaa ctttaccgga tttcaaagct cgagcagata catatacttt 1567981 tttaggtttt ccgttcacaa ggatacgaac cttttgaaga ttcgcgcccc aagtgcgctt 1568041 agaagcgttc attgcgtgag aacggttatt cccagctgtt gtttttttac ctgtgataac 1568101 gcatttacgt gccatttgtt tccctcctca cttgcacaaa acatctactt tttaacattc 1568161 atataatctt agatgctttc gatatggata ctttaaataa tttaccacag ctaaaaaacg 1568221 tttgcaacta ttgtttcatc atctttcaag aaaattcact tgacatcttg cggaaacagc 1568281 agcgctatag tatatgtaga ggtacggcca gcgattattg cctggtcttt tcataatgga 1568341 aaccatatag tagaatagct gtaactctat gcattcgaag gaggaactag tgtgtccatt 1568401 gaattaagaa cgaagtacgg acagattgat atatctaatg aagtcatcgc gatggttgca 1568461 ggaggcgcgg cggttgactg ttacggcatt gtcggcatgg cctctaaaaa ccagattaaa 1568521 gacggactga ctgaaatcct tcggaaagag aatttcagca ggggtgtcca agttcgccaa 1568581 gaaggagaac agatacatat cgacatgtat atcattgtca gctacggcac gaaaatttct 1568641 gaagtggcac ataatgtcca aacaaaagta aagtacacag taaatcaaac catcggactg 1568701 gcagtggatt ctgtcaatat ttatgtccaa ggcgtacgag tgacgaaccc gtagttagga 1568761 ggagtaggat tgtctatcag aacattagac ggcagaacct ttgccgagat gattcttgcg 1568821 ggagcgcaga atctgtctca aaacgccagt gcagttgatg cactgaacgt gttcccggtg 1568881 ccggacggtg atacgggaac aaatatgaac ctgtcgatga cttccggagc aagagaagtt 1568941 gaacaaatgg atacggatga tatcgggaag gtgggctccg cgttatctaa agggctgctc 1569001 atgggagcac gcggaaattc aggagttatc ctatcccaat tgttccgcgg atttagcaaa 1569061 aacattgaaa cgaaaaaaga aattaatgca cttgagtttg ccgctgcgct gcaagcaggt 1569121 gtagacatgg cgtataaagc tgtcatgaaa cctgtagagg gcaccatttt aacagttgca 1569181 aaagacgctg caaaaaaagc aatgatctta gcagaaaaag aaaccgatat cactgcgctg 1569241 atgactgcag tgacagaaga agcagaggcg tctttaaacc gcacccctga attgctacct 1569301 gtcctaaagg aagtaggagt tgtcgatagc gggggcaaag gcctgctctg tgtgtatgaa 1569361 ggtttccttg cttcattaaa aggtgaaact gtacctcaga aagcagttct tccgtcactt 1569421 gacgacatgg tcagcgcaga gcatcacaag agcgcgcaaa gcatgatgaa taccgaagat 1569481 attgaatttg gattctgtac cgaagtgatg gttaggcttg atcagacaaa aagagagttc 1569541 gacgaaggca cgttcaggca agacctcagc cagttcggag attctctgct tgtgattgcg 1569601 gatgaatcgc tggcgaaggt tcatattcat gctgaagagc cgggaaacgt gttaaactac 1569661 gcccagcatt acggtgaatt gatcaaaata aaaatagaaa atatgagaga acagcatacc 1569721 tctatcatca gtcaagaaag caaacctgca gacaacgaaa caccgccggc aaaacagccg 1569781 tatggcattg tgactgtagc gatgggagaa ggaattgcag acctatttaa aagcattggc 1569841 gcttctgttg tgattgaagg cggccagacc atgaacccaa gcactgagga tattgttgat 1569901 gccgtgaagt ctgtaaatgc agatacggta tttatcctgc ctaacaactc caacattatc 1569961 atggctgcta accaagcggc cagcgtagtg gatgaacagg tttttgtcat tcctgctaaa 1570021 acggttccgc aagggatgtc agctctgctg gcttttaacc cggatcaaga agctgaagcg 1570081 aacgaggcca atatgctaag cgccattcag caagtaaaaa gcggacaggt gacgttctca 1570141 gtcagagata ctcatattga cggtaaagac attaaaaaag gcgactttat gggcattctg 1570201 aatggaacga ttatcggcac ttctgaaaat cagctgtcag ccgcgaaaat gctgctgtca 1570261 gaaatgatcg gagaagatga tgaaatcgtg accattctat atggtgagga tgcgtctcag 1570321 gaagaagctg agcagcttga agcgtttctc agtgaaaagt acgaggagat tgaggttgag 1570381 atccacaatg ggaaacagcc tctgtattcg tatatagttt cagcagaata gaagggcaat 1570441 ttgcccttct attcttatgt ctgcttttaa gtgcggcagc gctgtaacgc gcccgcttgc 1570501 cattttatat ctgatcaatt agtctagaag caaagcgcta ataagctctg gttcataagg 1570561 aggaatagca tgaaatacag aagcgttttt gatattatcg gcccggttat gatcggtccg 1570621 tccagctctc atacagcggg agctgctaga atcgggagag tggccagaag tttatttggc 1570681 agagagcctg agcgcatcat tgtatctttt tacggctcgt ttgcggaaac gtataagggc 1570741 cacggcacag atgtcgcgat tatcggcgga ttgcttgatt ttgatacatt cgatgaacgg 1570801 attaaaaccg ctatacaaat tgcagaagct aaaggaattg atatagagtt tcgggtagaa 1570861 gacgcagtcc cggtccaccc gaacacagca aaaatcacca tttctgatga aaagggtgag 1570921 ctggaactga cgggtatttc gattggcgga ggaaagattg aaatcacaga attgaatggt 1570981 tttgagctcc ggctgtcagg aaatcatccg gccatattag ttgttcataa tgacaagttt 1571041 ggcacaattg ccggtgttgc caatgttctg gcgaaatttt caatcaacgt aggacatatg 1571101 gaagtagccc ggaaagatat cggccagctt gcgctgatga caatagaggt cgatcaaaat 1571161 attgacgacc acattctcga cgagctgtcg aagctgccga atattattca agtgacaaag 1571221 attgctgact agcgaaaagg gtcaggagga gccagttatg tttcgtaatg taaaagaatt 1571281 aattgagatt actaaagaaa aacaaatatt gatctctgat gtgatgatag ctcaagagat 1571341 ggaagtaaca gaaaaaacaa aagaggacat ttttcagcag atggatcata acctgtctgt 1571401 tatggaagcg gcggttcaga aaggactcga gggagttacg agccaaacgg gcttaacagg 1571461 cggagatgcc gttaaattgc aggcctatat tcgatcagga aaaagcctgt ctggcccgct 1571521 gattttagat gctgtatcga aagccgttgc aacaaatgaa gtaaatgcag ccatgggaac 1571581 catctgtgcg acaccgactg caggttctgc cggtgtggtg cccggtacgt tatttgctgt 1571641 aaaagaaaag ctgaatccaa caagagaaca aatgatccgc tttttgttta cagccggggc 1571701 tttcggattt gtcgtggcca ataacgcaag catttccggc gccgccggag gatgtcaggc 1571761 agaggttgga tcagcttcag gcatggcggc tgcggctatt gttgaaatgg caggaggaac 1571821 acccgaacaa agcgcggaag ccatggccat tacattaaaa aatatgctag gcctcgtgtg 1571881 cgaccctgtt gcagggcttg ttgaggtgcc ttgcgtgaaa cggaatgcga tgggcgcgtc 1571941 aaatgcgatg attgctgctg atatggcatt ggcgggcatt acaagccgta ttccatgtga 1572001 tgaggttatc gatgccatgt ataaaatagg ccaaacgatg ccaactgcac ttagagaaac 1572061 aggccagggc ggtttagcgg caacaccgac aggaagagaa ttagagaaaa aaattttcgg 1572121 aggagcgcta ggttcacgtg aaacaacatc agcaaactag tatagctaac attaagggta 1572181 ttgggccgga aacagaaaaa acattgaatg aactcggtat ttatgacatt tctgatcttc 1572241 tgaattattt cccttatcgc tatgatgact acgagctgag ggatttagaa gaagtaaagc 1572301 atgatgaaag agtcacagtc gaagggaagg ttcattcaga gccttctctt acctattacg 1572361 gaaaaaaacg aaacaggctg acattcaggc ttctggtcgg ccactattta atcacagccg 1572421 tatgttttaa ccggccttat ttgaagaaga agctttcgct cggctctgtg gtgacggttt 1572481 caggtaaatg ggacaagcac cgccaaacca tctctgttca ggagttgaaa aacgggccgc 1572541 atcaagaaga caaaagcatt gaaccagtgt attctgtgaa agaaaatgtt accgtcaaaa 1572601 tgatgaggcg ctttattcag caggcgctga cccaatatgc agactcactt cctgatcctc 1572661 ttccggaaaa gctaagaaaa agctataaac tgcctgacta ttatcaagcg ttaaaagcaa 1572721 tgcaccagcc tgaaacaagg gaagcattaa agcttgccag acggcggttt gtttatgaag 1572781 aatttttgtt gtttcagttg aaaatgcagg cgttccgaaa ggcggaaaga gagcagacac 1572841 aagggatacg gcagcgtttt tcaaacgaag aactcatgag atttatcaaa agcctcccgt 1572901 ttcccctcac aaacgcccag tcacgcgttc ttcgcgaaat aacagcagac atgtcttctc 1572961 catacagaat gaaccgtctt cttcaagggg acgttggatc aggaaaaacg gcagtcgccg 1573021 ccattgcact gtatgccgcg atcctatccg gataccaagg agcgctcatg gtgccgacag 1573081 aaattctggc cgagcagcat gctgattcgc tcgtttcgct atttgaaaaa tgggacgtca 1573141 gcgttgctct tttgacaagc tctgttaaag gaaagcggcg aaaagaactg cttgagcgtc 1573201 ttgcggcggg tgagattgat attcttgtag gaacccatgc tttaatccaa gacgaggtgg 1573261 agtttaaggc gttgagtctc gttattactg atgaacagca cagatttgga gttgagcagc 1573321 gcaaaaagct tcggaacaaa gggcaggatc ccgatgttct ctttatgaca gccactccaa 1573381 tcccaagaac attagcgatc acagtattcg gtgaaatgga tgtatctgtc attgatgaga 1573441 tgccggctgg acgaaagcga attgaaacct attgggtaaa acatgacatg cttgatcgta 1573501 ttttggcatt tgtcgaaaaa gaattaaagc aaggcaggca ggcttatatc atctgtccgc 1573561 tgattgaaga atcagataag cttgatgtgc aaaacgccat tgacgtgtac aatatgcttt 1573621 ctgatatttt tcggggaaaa tggaatgtcg gccttatgca tggaaagctg cattccgatg 1573681 aaaaagatca ggtcatgaga gaattcagcg caaatcactg tcaaattctc gtatcaacca 1573741 ctgttgtgga ggttggcgta aatgttccga atgcaacaat tatggtgatt tatgacgccg 1573801 accgtttcgg actatcacag cttcaccagc tgcgcggccg tgttggacgg ggtgagcatc 1573861 aatctttctg tattctgatg gctgatccaa aatcagaaac agggaaagaa cggatgagga 1573921 tcatgtcgga gaccaatgac ggtttcgagc tgtctgaaaa ggatctggaa ctgagaggtc 1573981 ccggtgattt cttcgggaaa aaacaaagcg gaatgccgga atttaaagtg gcggacatgg 1574041 ttcatgatta cagagcgctt gaaacggcaa ggcaggatgc tgcgaatctt gtggcttctg 1574101 acgcgttctg gaaggagccg gaatacgctg tgttaagaga tgaattgctg aagagcggag 1574161 taatggacgg ggaaaaatta agctgagtat cagaagtttt tggtgttcag ccagaaacaa 1574221 tcgttgcatt ccaatctatg aaattatata ctactattag tacctagtct taattgtccg 1574281 gatggtgttt agatatgaga agaaataaga gagaacgcca ggaattactt cagcagacga 1574341 ttcaagcaac cccctttatt acagatgaag aactagcggg taaattcggg gtgagcatcc 1574401 agacgatacg tttggaccgc ttagagcttt ccatacctga actgagagaa agaattaaga 1574461 acgtggcaga gaaaacactt gaggacgaag tgaagtccct gtcacttgat gaagttatcg 1574521 gagaaattat tgaccttgag ctggatgatc aggcgatatc cattttagaa ataaaacagg 1574581 agcacgtgtt cagccggaat cagattgcga gaggacacca tttatttgca caggcgaatt 1574641 ctttggccgt tgcagtcatt gatgacgagc tggcgctgac tgcaagtgca gacatccgct 1574701 ttacaagaca ggtaaagcag ggtgaacgtg tcgtagcaaa agcgaaagtg acggctgtcg 1574761 aaaaagaaaa aggaagaacg gttgtcgaag tgaacagcta cgttggcgaa gaaattgttt 1574821 tttctggacg ctttgacatg tatcgttcaa aacattcata aaggtggagc atgcatgaga 1574881 atagctgtag atgcaatggg aggagaccac gctcccaaag ctgttattga cggagttata 1574941 aaaggtatag aggcatttga tgatctccat atcacacttg tcggtgacaa aacaacgata 1575001 gaatcacatt taacaactac atcagatcgc atcacggtgc tgcacgcaga tgaagtgatt 1575061 gagcctacgg atgaaccggt ccgtgccgtg cgaagaaaaa agaactcatc tatggttctt 1575121 atggcgcagg aggttgcgga aaacagagct gacgcctgca tttcagcggg aaataccggt 1575181 gcattaatga cagccggtct ctttattgtc gggagaatta aaggaattga ccgtccggcg 1575241 cttgctccga cacttccgac tgtttcggga gacggatttc ttctccttga tgtcggcgcc 1575301 aatgtcgatg ccaaaccgga gcacctcgtt caatatgcca tcatgggttc tgtttattct 1575361 cagcaagtgc gcggtgtcac ttcaccgaga gtcggacttt taaatgtcgg aacagaagat 1575421 aaaaaaggaa acgaactgac gaagcagacg tttcaaattt taaaagaaac agcaaacatc 1575481 aattttatcg gaaacgtgga agcgcgagac cttttagatg atgtggcgga tgttgtagta 1575541 acagacggct ttaccgggaa tgttacactc aaaacgctgg aaggctctgc gttgtcaatt 1575601 tttaaaatga tgagagacgt aatgacgtct actttgacat ccaagcttgc agcagctgtg 1575661 ctgaaaccaa aattgaaaga aatgaaaatg aaaatggagt attcgaatta tggcggagca 1575721 agtctttttg gcttaaaagc gcctgtgatc aaggcgcacg gctcttcaga ttcaaatgct 1575781 gtattccatg cgattcggca agcaagagag atggtcagcc aaaatgtggc tgcgctcatt 1575841 caggaagaag tgaaagaaga aaaaacagat gagtagtctg gaggttttta catcatgagt 1575901 aagattgcat ttttattccc gggtcaggga tcacaattta tcggcatggg aaaagagctt 1575961 tatgagcagg tgcctgctgc aaagcgtctg tttgatgaag ccgatgaaac gttggaaaca 1576021 aaactcagct cgcttatttt tgagggggat gctgaagaat taacacttac atacaatgcg 1576081 cagcctgctt tgcttacgac aagcatcgct gttcttgaga aatttaaaga atctggcatt 1576141 acacctgatt tcacagcagg acacagcctt ggtgaatatt ctgcactggt tgcggctggc 1576201 gctctgtctt tcaaagatgc tgtttatact gtcagaaagc gcggagagtt tatgaatgaa 1576261 gcggtgccgg ctggcgaagg agcaatggct gcgattctcg gcatggatgc tgaagcatta 1576321 aagcaagtaa ccgataaagt cacagaggaa ggcaaccttg tacagcttgc gaatctcaac 1576381 tgtcctggcc aaatcgtcat ttccggaaca gctaaagggg ttgagcttgc atctgaactg 1576441 gcaaaagaga acggcgcaaa acgcgcaatt ccgcttgaag taagcggtcc gttccattct 1576501 gaactgatga aaccggctgc tgaaaagctg aaagaggtat tggacgcctg tgacataaaa 1576561 gacgctgacg ttccggtcat ctcaaatgtt tctgctgacg tgatgactga aaaagcagat 1576621 atcaaagaaa aacttattga gcagctttac tctccggttc gttttgagga aagcattaac 1576681 aagctgatcg cagagggtgt tacgactttt attgaaatcg gtcccggaaa agtgctttca 1576741 ggccttgtga aaaaagtgaa tagacggtta aaaacaattg ctgtatcaga tccggaaacg 1576801 atcgagctgg caattcaaac gcttaaggag gagaatgata atgcttaatg ataaaacggc 1576861 tattgtcact ggcgcatccc gcggaatcgg ccgctcaatc gcccttgatc tggcaaaaag 1576921 cggagcaaat gttgtcgtga actactccgg caatgaagcg aaagcaaatg aagtggtaga 1576981 tgaaatcaaa tcaatgggca gaaaagcaat tgctgtaaaa gcggatgtat caaatcccga 1577041 agatgtacaa aacatgataa aagaaacatt gtctgttttt tctacgattg acattctggt 1577101 taataatgcg ggaattacaa gagacaatct catcatgaga atgaaagaag acgaatggga 1577161 tgacgtcatt aacattaacc tgaagggtgt tttcaactgc acaaaagctg ttacaagaca 1577221 aatgatgaaa cagcgttcag gccgcattat taacgtatcg tctatcgtcg gcgtcagcgg 1577281 aaaccctgga caagccaact acgtggctgc aaaagccggc gtcatcggtt taaccaaatc 1577341 ttctgctaaa gagctcgcca gccgaaatat tacggtaaac gcaatagcgc caggatttat 1577401 ctcaactgat atgacagata aacttgcaaa agacgttcaa gacgaaatgc tgaaacaaat 1577461 tccgctcgcg cgctttggtg aacctagcga tgtcagcagt gttgtcacgt tcctagcttc 1577521 agagggagct cgttatatga caggccaaac gcttcatatt gacggcggaa tggtgatgta 1577581 agttttttct cgaaaatttc atcgtagttt ctctagtttt ttaaaaacga atccactata 1577641 atacttgagg ggaggtgaat tgctatggca gacacattag agcgtgtaac gaaaatcatc 1577701 gtagatcgcc ttggcgttga tgaagcagac gtcaaacttg aagcttcttt caaggaagac 1577761 ttaggtgctg attccctaga tgtagttgag cttgttatgg aacttgaaga cgagtttgat 1577821 atggagattt ctgacgaaga tgctgaaaag attgcaacag tcggcgacgc tgtgaactac 1577881 atacaaaacc agcaataagc tgatgctaaa agtcccgccg aaacgcgggg ctttagccct 1577941 ttattcgtgc agttattaca gcatgccgct tttacgcgcg ctgtatccgg tttagtcaga 1578001 gaagcgcggt gaacctgatg tgcctatgga ggttactatg tcaaaacact cacattataa 1578061 agataaaaaa aagttctata aaaaagtaga acaatttaaa gagtttcaag aacggatttc 1578121 ggttcacttt caaaatgaaa agcttttgta tcaagcattt acacattcat cttatgtgaa 1578181 tgagcatcgg aaaaagccgt atgaagataa tgaaaggctt gaatttttag gtgacgctgt 1578241 tttggaactg acgatctcca gattcttatt tgccaaatac ccggctatga gtgaaggaga 1578301 tttgacgaaa ttgagagccg caattgtttg cgaaccgtct ctcgtttcat tggctcacga 1578361 gctgtcattc ggcgatcttg tcctgttggg taaaggcgag gaaatgacag gcggaagaaa 1578421 gcgtcctgct ctattggcgg atgtttttga ggcatttatc ggagccttgt accttgacca 1578481 aggattagag ccggtcgaaa gtttcttaaa agtttatgtg ttccctaaaa ttaacgatgg 1578541 tgctttttct catgtgatgg atttcaaaag ccagctgcag gaatacgtgc agcgggacgg 1578601 caaaggctct ctggagtata aaatctccaa cgaaaaagga cctgcgcaca accgtgaatt 1578661 tgaagccatc gtatctctaa aaggtgaacc actcggagtc ggaaacggcc gttcaaagaa 1578721 agaagccgaa cagcacgctg ctcaggaagc tttagctaaa ttgcaaaaac accatacgaa 1578781 acaataaaat cccccttatg actcaggggg atttcagtat gtatgccgtc ttatttgacc 1578841 aatgtttatg atagaattga aatacttatt acataaggag gatcgctatg ttcctcaaac 1578901 gtttagacgt tataggattt aaatcatttg cagaacggat ttccgtagac ttcgttaaag 1578961 gcgtgacagc agttgtcggg ccgaacggaa gcggaaaaag caacatcacg gatgccattc 1579021 gctgggttct cggcgaacaa tcggcacgct ctcttcgcgg cggaaaaatg gaagacatca 1579081 tttttgctgg gagtgattca agaaagcgat taaatctagc tgaagttacg cttactcttg 1579141 ataatgatga tcatttcttg ccaattgact tccacgaggt gagtgtcaca agacgtgtgt 1579201 acagatcagg tgagagtgag tttctgatta acaatcagcc atgccgcttg aaagatatta 1579261 ttgatttatt tatggactct gggcttggta aagaagcatt ttctattatc agccaaggga 1579321 aagtggaaga gatcctgagc agcaaagcgg aggatcgccg cagtatcttt gaagaagcgg 1579381 ccggggtgct taaatataaa acgagaaaga aaaaagcaga aaataaactg tttgagacac 1579441 aggacaatct aaatcgggta gaagatatat tacatgagct tgaaggacag gttgaacctc 1579501 ttaaaattca agcttcaata gcgaaagact accttgagaa aaagaaagag ctggagcatg 1579561 ttgaaattgc gctgactgcc tatgatatcg aagagctgca tggtaaatgg tcgactctta 1579621 aagagaaagt gcagatggca aaagaagaag agcttgctga atcgtctgct atttctgcga 1579681 aagaagcaaa gattgaggat acaagggaca aaatacaagc gcttgatgag tcagtagatg 1579741 agctccagca agttttactg gtaactagtg aagagctgga aaagcttgaa ggccgtaaag 1579801 aagtcctgaa agaacgaaag aaaaacgctg tgcaaaacca agaacagctt gaagaagcca 1579861 tcgttcagtt ccagcaaaaa gaaacggttc tgaaagaaga gctttcgaag caggaagctg 1579921 tcttcgaaac gcttcaggct gaggtgaagc agttaagggc gcaagtaaaa gaaaaacagc 1579981 aggctctcag tcttcacaat gaaaatgtcg aagagaaaat cgagcagctg aaaagtgatt 1580041 attttgagct gttaaacagc caggcttcga tacgcaacga actccagctt cttgatgacc 1580101 agatgtccca atccgctgtc acattgcaga gacttgcgga caacaatgaa aagcacctgc 1580161 aggaacggca tgatatttct gcgcgtaaag ccgcatgtga aacggaattt gcccgaattg 1580221 agcaggagat tcacagtcaa gtcggtgcat atcgtgatat gcagacaaaa tatgagcaga 1580281 aaaagcgcca atacgaaaaa aatgaatccg ctctgtatca ggcataccaa tacgttcagc 1580341 aagcgagatc aaaaaaggac atgcttgaga cgatgcaggg agatttctcc ggcttttatc 1580401 aaggtgttaa agaagtgctg aaagcgaaag agcgccttgg cggaattcgc ggagcggttc 1580461 ttgagctgat ttctacagaa cagaagtatg aaacggccat tgaaatagcg ctcggcgctt 1580521 ctgctcaaca cgtcgtgacc gacgatgaac aatctgcccg caaagcgatt caatatttaa 1580581 agcagaattc cttcggccgg gcgacgtttc tgcctctttc tgttattaga gaccgccagc 1580641 ttcaaagccg tgacgcggaa acagccgccc ggcattcatc atttctcggg gttgccagtg 1580701 aacttgtcac atttgatcct gcgtatcgaa gcgtcatcca gaatcttctt ggaaccgttc 1580761 tgatcacaga ggacttaaag ggtgcaaacg agcttgcgaa gcttctcggg caccggtacc 1580821 gcatcgtaac ccttgaggga gatgttgtga accccggtgg ttcaatgacg ggcggcgcgg 1580881 ttaaaaagaa aaataactcc ctccttggaa gaagccggga gctagaagat gtgacgaaac 1580941 ggctcgctga aatggaagag aaaacggcac tgcttgaaca agaggtcaaa acccttaagc 1581001 actccattca ggatatggag aaaaaactgg ctgacttaag agaaaccggg gaaggcttaa 1581061 ggttaaagca gcaggatgtg aaaggccagc tgtacgaact tcaagttgcc gagaaaaata 1581121 tcaataccca tttagagctc tatgatcaag aaaaatctgc tctgtcagaa agcgatgaag 1581181 agagaaaagt gcgcaaacgc aagcttgaag aagagctctc tgccgtatct gaaaagatga 1581241 aacagcttga agaggacata gacagactga caaaacaaaa acaaacgcaa tcctcaacga 1581301 aagagtctct ctccaacgag ctgactgagc tgaagatcgc agcggccaaa aaagagcagg 1581361 cttgcaaggg ggaagaggac aaccttgcca gattaaagaa agagctcact gaaacagagc 1581421 ttgcgttaaa agaagcaaaa gaagacttaa gcttcttaac gtcagagatg tcatctagca 1581481 ccagcggcga agaaaagctg gaagaagcag caaaacataa attgaatgac aaaacgaaaa 1581541 cgatcgaact gattgcatta aggcgcgatc agcgcatcaa gcttcagcat gggcttgata 1581601 cgtatgagcg tgagctgaaa gaaatgaaac gcctgtataa acaaaaaaca acgctcttaa 1581661 aagacgaaga agtcaaactt ggacgaatgg aagtcgagct tgataattta ctccaatact 1581721 tacgggagga atacagcttg tcctttgagg gggcaaaaga gaaatatcag cttgaaactg 1581781 atccagagga agccagaaag cgcgtgaagc tgattaaact cgcaattgaa gagctgggta 1581841 ccgtgaacct cggaagcata gatgagtttg agagggtcaa cgaacggtac aagtttctgt 1581901 cggaacaaaa agaagattta acagaagcga aaaatacctt gttccaagtg attgaagaaa 1581961 tggatgaaga aatgacgaag cgctttaacg acacattcgt ccaaatccgc tcacactttg 1582021 atcaagtttt ccgctcctta ttcggaggag ggcgagctga actgaggctc accgatccta 1582081 acgatctgct tcattcagga gtcgagatta tcgctcagcc gccggggaaa aagctgcaaa 1582141 acttaaacct cctgtcaggc ggagagcgtg cgcttactgc tatagcgctc ttattctcaa 1582201 tcctaaaggt tcgtccagtg ccgttttgcg tccttgacga agtagaggct gcgctcgacg 1582261 aagcgaatgt gttccgattt gcgcagtatt taaaaaaata cagcagcgat actcagttta 1582321 ttgtgattac ccacagaaaa ggaacgatgg aggaagcgga tgtgctttat ggcgtaacca 1582381 tgcaggaatc cggtgtttcc aaggtaattt cagttaagct ggaagaaaca aaagaattcg 1582441 ttcagtaacg aggaaagagg ttaaaagatg agctttttta aaaaattaaa agagaaaatc 1582501 acaaaacaga cagattccgt atctgaaaag tttaaggatg gccttgaaaa aacaagaaac 1582561 tcctttcaaa acaaagtgaa tgatcttgta tcccgttacc gtaaagtgga tgaggatttc 1582621 ttcgaagagc ttgaagaggt tcttatcagc gcggatgtcg gttttacaac cgttatggaa 1582681 ttaatagatg agctgaaaaa agaagtcaaa cgcagaaata ttcaagatcc aaaggaagtc 1582741 cagtcagtga tttctgagaa actggtcgag atttataaca gcggagatga gcaaatttca 1582801 gaactgaaca tccaggatgg gcgtttaaac gtaatccttc tggtaggtgt aaacggcgtc 1582861 gggaaaacaa caacgatcgg aaagcttgct cataaaatga aacaagaagg aaaatctgtt 1582921 gtacttgccg ccggagacac ttttagagcg ggagccattg aacagctgga agtatgggga 1582981 gagcgtacag gagtgcctgt cattaagcag acggcaggaa gcgatccggc ggctgtcatc 1583041 tacgatgctg ttcatgctgc gaaagcaaga aatgccgatg tattaatttg tgatacggca 1583101 gggcgtctcc aaaacaaagt aaatctcatg aaagagcttg aaaaagtaaa acgtgttatc 1583161 gaaagagaag ttcctgaagc tccgcatgag gtgctgcttg cccttgatgc cacgaccggc 1583221 caaaatgcaa tggctcaggc aaaagaattc tctaaagcaa caaatgttac cggcattgct 1583281 ttaacgaagc ttgacggtac ggcaaaaggc ggtatcgtcc ttgcgattcg caacgagctt 1583341 cacatcccgg ttaaactagt cggtttagga gaaaaagttg atgaccttca ggaatttgat 1583401 ccagaatcct atgtgtacgg actcttttca gatttagtgg aaaaagccga cgattaagaa 1583461 aaaggcccca acatcttggg gcctttttct tttttatctt cttacttgat aggcgaaatg 1583521 ataaaggctg ttatcagtgg ataccagtct tgactcacca gaaaaaactc tgaatgggat 1583581 gatgtcatag taatgaacgg aaacagatgt gtaatacgta tagtaaccag cagctggccc 1583641 caaatacatt ggaacctcaa atgttccgtt tgcatcagtc gttcctgaag cagtttgtgt 1583701 tgtgtttccg accttcgtgt ccgcttcaaa tcttacgggc gcgtttggca ctggctgtcc 1583761 gttttggtcg agtaatttgc cgcttactgt aatattgtac ttgactcgcc aatattgacc 1583821 ttgtccgtaa ttgattttac cgtatacccc tccatctgtg ctgatatttg tgattgaggc 1583881 cttataaggt gcctcagcag cgtctgcttg ctgtgccggg aaacctattg taaacagggc 1583941 tgccagacat aacataaaca ataaaccgat ttttttcata aaaatcctcc ttaaaatagg 1584001 gttcatatac aatatcggaa taaattggat gatatttagc gtattttgga aaagttaatc 1584061 gccgctttga caagataaaa acttgacagt gtcattaaaa ccgtgtaaac taagttatcg 1584121 taaagggatt tgacttaaca aaggggagag ctcaaatgtc actcgaaaag acaacgagaa 1584181 tgaattatct gtttgatttt tatcagtcgt tgttgacgtc aaaacagaag agctatatgt 1584241 cgctttatta tttggacgat ttctccctag gcgaaatagc cgaagaatat gaggtttcaa 1584301 gacaagctgt ttatgataac atcaaacgaa cagaagcaat gcttgaacaa tatgaagaaa 1584361 agctgctcct tttgaaaaag tttcaggagc gtaaagagat gtttaataag ctgaaggagc 1584421 ttgcttccgg ttcaaaagaa gaggaagaaa ttacagctct gattgaagcg cttgagaaat 1584481 tagattagga ggcggcaaac tatggcattt gaaggattag ccgaccgact gcagcagacg 1584541 atttctaaaa tccgcggaaa agggaaagtc agcgaacaag atgtaaaaga gatgatgcgt 1584601 gaggtccgtc ttgcgctgct tgaggctgac gttaacttta aagtagtcaa ggattttgtc 1584661 aaaaaagtaa gtgaacgcgc tgtaggccaa gacgtcatga aaagtctgac gcccggccag 1584721 caggtcatta aagttgttca agaggaactg actgagctga tgggcggcga agagagcaaa 1584781 atcgccgtcg caaaaaggcc gccgactgtt attatgatgg tcggtctcca aggtgccggt 1584841 aaaacgacaa caagcggtaa gcttgcgaat ctgctgcgca aaaagcataa tcgcaaaccg 1584901 atgctggttg ctgccgatat ttaccgccca gccgcaatta agcagctgga aacactcggc 1584961 aaacagcttg atatgcctgt tttctctctt ggcgatcagg tcagtcctgt agaaatagct 1585021 aaacaggcta ttgagaaagc caaggaagaa cattatgact acgtcatttt ggatacggca 1585081 gggcgcttgc atatcgacca tgaactgatg gatgaactga ccaacgtcaa agaaatcgcg 1585141 aatccggaag aaattttcct ggttgtcgat tcaatgaccg gtcaggacgc tgtgaatgtt 1585201 gccaaaagct ttaatgaaca gctcggttta accggtgttg tgttgactaa gctggatgga 1585261 gacacacgcg gcggggctgc gctttctatt cgcgctgtca caaacacgcc aattaagttt 1585321 gcaggtttgg gcgaaaagct tgatgcgtta gagccgttcc atcctgaacg catggcatca 1585381 aggattctcg gcatgggcga cgtgctgaca ttgattgaaa aagcacaggc cagcgttgat 1585441 gaagacaaag ccaaagagct ggaacaaaaa atgagaacga tgagcttcac attggacgat 1585501 tttctggagc agctcgggca agtcagaaac atggggccgc ttgatgagct tctgcaaatg 1585561 atgccgggtg caggtaaaat gaagggcctg aaaaacatcc aagttgatga aaaacagctg 1585621 aatcatgtgg aagcaatcat caaatcaatg actgttcttg aaaaagaaca gccggatatt 1585681 atcaatgcca gccggcggaa gcggattgca aaaggaagcg ggacatccgt acaggaagtc 1585741 aaccgtctgc ttaagcagtt tgatgaaatg aaaaaaatga tgaagcagat gacaaacatg 1585801 tcaaaaggca agaaaaaagg gtttaagcta ccttttatgt aatcggttat acatgataaa 1585861 accgttgtta agaaaaaaca ctttacaaac acttttatca ttgttaatat actatcttgt 1585921 tgaaatattt tcggaggtgc tagtaaaatg gcagtaaaaa ttcgtttaaa acgtatggga 1585981 gcaaaaaaat ctcctttcta tcgtattgtt gtagcagatt ctcgttcacc acgtgacggc 1586041 cgtttcatcg aaacagtcgg aacttacaac ccggttgcaa aaccagcgga agtaaaaatt 1586101 gacgaagagc ttgctcttaa atggcttcaa actggagcga aaccatctga tacagttcgc 1586161 aacttgttct ctagccaagg aatcatggaa aaattccaca acgctaaaca aggcaagtaa 1586221 tgactgatca acacttggaa gatttgattg tccacattgt gacgccgctt gttgatcatc 1586281 cagatgacat tcgcgtcata agagaagaaa ccgatcaaaa gattgcgctg cgcttatctg 1586341 tccataagtc agataccggt aaagttatcg gaaagcaagg ccggactgca aaagcgattc 1586401 gaacagctgt atttgcagct ggcgtacagt cttctaagaa agttcaattt gaaatatttg 1586461 actaaaaggg agagggccgg cacctcccct ttttttacac gcaaaaaaag ggtaaactga 1586521 tagaagctta ggcaaaatag aaaagcctgg acgagtaaaa gttttaaaag cggggagctt 1586581 ggtgcgatgc aaattattca ccgtgtagcc gttatgcaag tcttaaccga gcgcagtaaa 1586641 gaaaagcttt tagcttcttt tgctgagaag aaacaaatgc ttgaacgaga atgcagccag 1586701 ctctattttc agcttagaaa acatgagaaa gaacagcaaa accctaatat gattgaacaa 1586761 tttaaaaagg caatagaaaa gcgaaaagat gatataaaaa tcattgattt tcaaattgct 1586821 caagtacata cattgccgct tggcagtgag ttgaaagaaa aggaagtcga tgcgctgctg 1586881 acgattgaag ccggggatga ctggcatgag aaaacagcag cgaacaccat cgtcataaaa 1586941 gacggaaaag taattgaaat tcgccagagg tgatcatatg acaaagcgat ggtttaatgt 1587001 aggcaaaatc gtaaataccc acggaatcaa aggcgaagtg cgggtgattt caaaaacaga 1587061 ttttgccgaa gaacgataca agccgggaaa cacgctgtat ttgtttatgg acggccgtaa 1587121 cgaaccagtg gaggtaacgg taaacacaca tagactgcat aagcaatttc atctcctgca 1587181 gtttaaagaa agacaaaacc taaatgaagt agaagagctg aaaaacgcaa tcattaaagt 1587241 tcctgaagaa gaattaggag agctgaatga gggtgaattt tatttccacg aaattattgg 1587301 gtgtgaagta tttactgaag aaggcgaact catcggaaag gtcaaagaaa ttttgacgcc 1587361 tggagccaat gacgtttggg tcatcggacg aaaaggaaaa aaagacgcac tcattcctta 1587421 cattgaatca gtggttaaac atatcgatgt cagggaaaag aaaattgaga ttgaactcat 1587481 ggaagggtta atagacgaat gaaaatcgat tttttgacgc tgtttcccga aatgtttgaa 1587541 ggcgtgctcg gctcatcgat tcttcaaaaa gcccaggaaa aagatgcggt gcagtttcaa 1587601 gtcgtaaatt tccgagagta ctctgataac aagcacaata ctgttgatga ttatccttat 1587661 ggcggcgggg caggcatggt tctcaagccc cagcctgttt ttgacgcggt cgaggacctg 1587721 acatcaaagg cagccgctgc tccgcgtatt atcctcgtat gcccgcaagg tgagcgtttt 1587781 acccaaaaaa aagccgaaca attagctaag gaagagcatt tgctgttcat ttgcggccac 1587841 tatgaaggct atgatgaacg cattcgcgag cacttggtaa cggatgaaat atcaattggc 1587901 gactttgttc tgacgggcgg tgagctccct gcaatgatga tcgcagacag tgtggtcaga 1587961 ctgcttccgg gtgtactggg taaagaggct tcccatattg aggattcctt cagcaccgga 1588021 cttttagagc acccgcatta tacaagaccg gcagattaca aaggtttaaa agtgcctgaa 1588081 acactcttgt caggaaacca tgcaaaaatt gaagaatggc ggaataaaga atcgatcaga 1588141 aggacctacc taagacgtcc ggatctgttg aaagaccacc cgcttacaga gcagcaaaga 1588201 aagtggattt ctgaatggga aaaagaatag attttattgc ataggctatg aaattgtgat 1588261 aagatactac ttgtggctta agcgggctta tccgctgcaa gcttgaaaac gatgttccgc 1588321 tgtgccggtt tttgtggcca agagcatctg ttggaaggag ttgaaaacga tgcaaaaact 1588381 aattgaagat atcacaaaag aacagcttcg tactgatctt cctgcgttcc gtcctggtga 1588441 cactttacgt gtacacgtta aagttgttga gggtaaccgt gagcgtatcc agatctttga 1588501 aggtgttgtg attaagcgtc gtggtggtgg aatcagcgaa acgttcacag ttcgtaagat 1588561 ttcttacggt gttggcgttg aacgtacttt cccagtacac acaccaaaaa tcgcgaaaat 1588621 cgaagttgta cgttacggta aagtacgccg tgctaaactt tactacctgc gtgaacttcg 1588681 cggaaaagcg gctcgtatta aagagatcag acgataatga taacgaacga aaagagcttg 1588741 ttacctgtaa caagctcttt ttttatacag aatttgaaaa tgccggacag gcatcgtaaa 1588801 atacataaag gacaacaatg aatcatgcat actgaagata aaggcggtgt tcgtgtcaca 1588861 tgacaattca atggttcccg ggccatatgg caaaagcaag aagggaagta accgaaaaat 1588921 taaaattaat cgatatcgta tatgaattgg tagatgccag aattccaatg tcatcaagaa 1588981 acccaatgat tgaagatatt ctaaaaaaca agccgcgaat tatgctgtta aacaaggctg 1589041 acaaagcaga tgcggcagtt acacagcagt ggaaagagca ctttgagaac caggggatcc 1589101 gctctctgtc tattaattct gtaaatggac aagggttaaa tcaaattgtg cctgcatcaa 1589161 aagagatcct ccaagaaaaa tttgaccgga tgcgtgcgaa aggtgtgaag ccgagagcga 1589221 ttcgcgcttt gattatcggc attccaaacg tcggaaaatc aacgctcatc aaccggcttg 1589281 caaagaaaaa catagcaaaa acgggagaca gacctggtat tacgacttct caacagtggg 1589341 tcaaagttgg gaaagaatta gagctattag atacaccggg aattttgtgg cctaaatttg 1589401 aggatgagct tgtcggtttg agactggcag tcaccggggc tattaaagac tcgattatca 1589461 atttgcagga cgtggccgtg tttggtcttc gttttctcga agaacattac ccagaacggc 1589521 ttaaagagcg ttatggcctt gatgagatcc cagaggacat tgccgagctg tttgatgcaa 1589581 taggtgaaaa gcggggctgt ctcatgagcg gtgggctcat caactacgat aagacgactg 1589641 aagtcatcat tcgcgatatt cgcactgaaa agttcggcag gctgtcattt gaacagccga 1589701 cgatgtaaag gcgcgcagaa atgcgggtct ttattttttc ttggctgaac cgatacatac 1589761 agtaagggag aagagaaagt gaatacatta accgtaaagg acattaaaga ccgtttgcag 1589821 gaagtgaagg atgcacaaga cccatttatt gcccaatgcg aaaacgaccc gagaaaaagc 1589881 gttcaaacgc ttgtagagca atggcttaaa aagcaagcga aagaaaaagc gctgaaagaa 1589941 caatgggtga atatgacttc ctatgaaagg ctggcaagaa acaaaggatt tcgcttgatt 1590001 gcaggtgttg acgaggtcgg ccgggggcca ttggcaggac cagttgtcgc cagcgcagtc 1590061 atccttccag aggaatgtga aatacttggg ctgacagact ccaaaaagct ttcagagaaa 1590121 aaacgcgagg aatattacga gcttattatg aaggaagcac tggcggtcgg gataggaatt 1590181 gtagaagcta ctgtgattga tgagatcaat atatatgaag cttcaaaaat ggcaatggtg 1590241 aaagcgatac aggatttgtc ggatacacct gattatttgc ttgttgacgc aatgacactt 1590301 ccgctcgaca cggctcaggc gtcaattata aaaggcgatg ccaaaagcgt gtctattgcg 1590361 gcaggtgcgt gtatcgcaaa agtgacgagg gaccgaatga tgagcgctta tgccgaaacg 1590421 tatcccatgt acggctttga aaaaaataaa ggctatggga caaaagaaca tttggaagct 1590481 ctcgctgcat acggcccaac tgaattgcac cgcaaaactt tcgctcctgt tcaatctttc 1590541 agataaatca ccatggacaa ggaggcacct ttttaaaatg aacatacgaa atgatgtgca 1590601 aaaggcgctg cagcaccttt tcgggcgtac agccgtcccg caggaaacat caaaagtaaa 1590661 cgaagcgcta aacggggaga agcgtctcct cttaggaaaa gtgcttcgtt tactaggaga 1590721 tcagcatgcc ctgatccaag tcggcaatca aactgttcag ggaaaacttg aaactcagct 1590781 tcgtcctcag gcatactatt ggttttccta cgaaaaaaaa acggcagagc aaacaggccg 1590841 tcttcaggtc gttcaaagct ttgatcaaaa tcctaaaacc attcaggatg cagctggcaa 1590901 acttttaaat gctatttcag tgaagacgtc aaacgcagct ctcatgatga caggagcgat 1590961 gctgaaaagc aaaacacccg taacagaaaa tgatatcaaa acagctgtcc gctggatgga 1591021 cacgctgcct tcgcaagaca caaaaaaagc agttgaaacg gttctcttcg ctttaaagcg 1591081 tgatcttccc attcactccg agattttgaa tggtgttcac gctgtgaaat cgcctgttcc 1591141 gttgcatcag cacgtatccc agctgctaca ggcaatcgac caaaaccctc agcagagcca 1591201 aatgatgtca aagctaaagg aagcagtcac ggtgctttta aatagtgaaa tcgatgtcca 1591261 tgcagaacgg ctgattgata agcttatttc tttaaccgac aatacgaaag caccttctcc 1591321 gacgaataca gctggaagca gggagcttag cacaccagct ggctcccccg gaaaagccag 1591381 cctgccgatt gcaaatcaca cagcagaaca gggaagcata caagaagagc ctgttaaaac 1591441 agcagcagac attccaatta aagaagcccg ccagctgctg gtgaagctga cggaatctgc 1591501 tgaaaaaaac agtctccaaa ttgtgaaaga agcagcaaat tggattaaag cggctgcttc 1591561 atcgggtgat agtaagtcac ttgcagcttc agctgtttta caggcggcac aagtcacaga 1591621 tcaggaagcc gaagtctttt taaaggctgt tcagcagaca gcaccccatt tggcggataa 1591681 ggcagatgtt ctttctttct tatccaaagt gaaaacggca atcggcgcaa gggacgaggt 1591741 tgcgttcatt aaagcgtttg aacaaggaag cgcagtcaca tctggcgaaa tgcaatccat 1591801 caagctggct ctttctgcct taagagcatc gcatgaggta gccgaaccag tcaaacaaga 1591861 agccgatcag ctttttcata aattaaatgg ccagcttttc atgcagcagg accatccatc 1591921 atacagccaa attgtaatgt catttccgat gttttcgaag tcaggggttc aggacatgac 1591981 tgttctgttt aaaggaaaga aagaagcgga tggaaagctt gatccttccc attgccgcct 1592041 tttgtttttg ctgcagcttg atacactaaa agaaaccgtc gttgattgct tggtacagca 1592101 aaaagtcatg accattacaa tagagactga tttcgagctg caggctgcga tcgatccgat 1592161 ggtgcccgcg cttaaacagg ggctaaagga aatggggtac agcctttcag gggtaaacgc 1592221 taaaaaaagg gttcacaccg aagaaaaggc ttcaatcgat caatatataa caagtatcag 1592281 tgatcaggaa gtggatgtga aaatatgaaa gagcagacac cgatcagaaa agctgttgct 1592341 ctccattatg acgaacaaaa agacaaggcg ccgagagtga ttgccacagg gaagggccat 1592401 gtagctgaca acattataaa agaagcgaaa aaagcagggg tcccgattca agaagatcgg 1592461 acccttgtcg aattaatgcg ccatttgacg gtagatgatc aaattcctga agctctttat 1592521 gaaacggtag ccgagatttt ttcattcatt tacaaattgg acgaaagcgt aaaaaacaaa 1592581 aaatagctaa aatattcccc atccttcttt gaaatttatg tttttaataa agtaaaagtt 1592641 tgaatgttta gaaggattaa aagattttgc atcgaactgt agacaattct tccagtatta 1592701 ttatagaatg aaagcgcagt ctattttagt tttgttacat aagttaggag gatgggaaat 1592761 gaatatccat gagtaccagg gaaaagaagt cctcagaaaa tatggggtat ctgttcctga 1592821 aggtaaagtg gcttttacag cagaagaagc agttgagagt gcaaagagct tatccagctc 1592881 ggtttatgtc gtaaaggctc aaattcatgc tggcggtcga ggcaaagctg gtggggtaaa 1592941 aatagcaaaa tcattagacg aagtaaaagc gtatgccgaa gaactattag ggaagaccct 1593001 agttacacat cagacgggtc cggacggcca agtaataaaa cgcttactta ttgaagaagg 1593061 ctgcgatatt aaaaaagaat attacatcgg tctagtgctt gaccgcgcca cttcaagaat 1593121 cgttttaatg gcttctgaag aaggcggaac ggaaattgaa gaggttgcgg agaaaacacc 1593181 agaaaaaatc aaaaaagctg tcattgatcc agctgttggc cttcaaggct atcaagccag 1593241 agaaattgca ttcgctatta atattccaaa agagctcgtg ggaaaagctg ctaaatttat 1593301 gcttggacta tataaagcgt ttgttgagaa agactgctca atcgccgaaa tcaatccgct 1593361 tgttgtgact ggcgacggaa atgtgatggc gcttgatgca aaattgaatt ttgacagcaa 1593421 tgcgttgtac cgacaaaagg acattatgga atacagagat ttggatgaag aagatccgaa 1593481 agaaattgaa gcgtccaaat atgatctaag ctacatttcc cttgatggaa atatcggctg 1593541 tatggtaaac ggcgcgggac ttgcaatgtc tacgatggat attatcaagc attatggagg 1593601 agaaccggcc aacttccttg atgtgggcgg cggtgcaacc gcggaaaaag tcacggaagc 1593661 atttaaaatc attctttctg atcaaaacgt taaagggatt tttgtcaaca ttttcggcgg 1593721 cattatgaaa tgtgatgtca tcgcagaagg ggttgttgaa gcgactagac aagttggttt 1593781 gacattgccg cttgtcgtcc gtcttgaagg cacaaacgtg gatctaggga agaaaatcct 1593841 tagtgaatca ggattaaaca ttacatctgc ggaatcaatg gctgacggcg cgcagaaaat 1593901 cgtatcctta gtttaagaaa gaatgaaagg caggggacca aataatgagt gttttcatta 1593961 ataaagatac aagagttatt gtgcaaggga ttacaggttc taccgcttta tttcatacga 1594021 agcagatgct tgaatacggc acaaatatcg ttggcggtgt aacacctgga aaaggcggaa 1594081 cagaagcgga aggtgttcct gtatttaata cagtggctga agcagttcaa acaaccggcg 1594141 ctaacgcgtc tgttatatat gtgcccgcac cgtttgcagc tgatgcgatt atggaagcgg 1594201 tagatgcgga gcttgatctc gtgatttgta tcacagaaca tatcccggtt ttggatatgg 1594261 tgaaggtcaa acgcttcatg gaaggcaaga aaacgagact gatagggccg aactgtcctg 1594321 gtgtcattac gcctgaagaa tgtaaaatcg gcattatgcc cggatacatc cataaaaagg 1594381 gtcatgtagg cgttgtatca cgttcaggaa cattaacata cgaagcggtg caccagctct 1594441 cagaagcggg tgtagggcaa tctacagctg ttggaatcgg cggcgaccct gtaaatggaa 1594501 caaactttat tgacgtttta aaagcgttta acgaagatcc tgacacacac gcagtcatca 1594561 tgattggcga aatcggcggt acggccgaag aggaagcggc agagtgggta aaagccaaca 1594621 tgacaaaacc ggtagtcggt tttattggcg gtaaaacagc acctcctggg aagcgcatgg 1594681 ggcatgcagg cgccattatt tccggcggga aagggacagc tgatgaaaaa atcaaaaccc 1594741 ttaatgcatg cggaatcgaa gttgcagaga caccttctgt catgggtgaa accttaatca 1594801 aggtgctgaa agagaagaac ttgttcgaaa cttgtaaaac gcattaataa aaaagggaca 1594861 gccgtcaagg ctgttcctgc tttttctaac aaaaggaggt caatctattg gatcaggccg 1594921 ctgtctgcct aacgatttgc agaatcaatc aattattatc cccatccctt ctattaaaat 1594981 ggtggaaagc cgatccgtct atgtcgctga catcacccgt gttacaaacg gttactcgtg 1595041 atcaaataaa agcagctgca ttaaaaaacg aaatagaaca attttatcca aagctcccgc 1595101 gtgtacttgc tgcttatcgt gagcaaggca ttaacaccat ccctatttct tcaaagcaat 1595161 atcctttctg gcttaaaagc atttatgatc cccctgccgt actgtttgca aaaggtgata 1595221 tgactcttct ttcgaaaggg agaaaaattg gaattgtagg cacaagaaat ccaacagctt 1595281 atgggaaaca agttgtcaat catcttacaa aagagatctg tcgtaaaggt tgggtgattg 1595341 tcagcggact ggcgtctggg atagacggaa tgtcccatgc tgcaagtatt aaggcgaagg 1595401 ggcggacaat tggcgtcatt gcaggcggat ttcaacacat ttatccccga gaaaaccttc 1595461 agttagcaga tcacatggct aaacaccata tcctgctgtc agagcaccca cctgaaacta 1595521 aaccccaaaa atggcatttc cctatgagaa accgtattat cagcggacta agtgaaggcg 1595581 ttattgtcgt tcagggcaaa gaaaaaagcg gttcgctgat tactgcctat caagcattgg 1595641 aacaagggag agaggtattt gccgtacccg gttcattgtt tgacccttac gccggaggtc 1595701 ctataaaact gatccagcag ggggctaaag ccatatggtc agcagaggat attttcgagg 1595761 aacttcctga gagaaacgtt caatatacgg aacccttttg aattatcgtt tgacaaacgg 1595821 tattgtaata tttaataata gtgaggattt aaagttgcat attgttttct atttaattaa 1595881 tgacgttcat gataaagaat gaaatgttga aagccaaata aagacagctg caaaaataaa 1595941 attgaaatat cttgaaaaga gagagaacac ctcttgaggg ggatgaaaat gtctgattat 1596001 ctagtcatcg tggaatcgcc cgctaaggcg aaaacgattg aacgttactt aggtaaaaaa 1596061 tataaagtaa aagcatcaat gggacatgtc cgggatcttc caaaaagtca aatgggagtt 1596121 gacatagaac agaattttga accgaaatat attaccattc gaggtaaagg cccggtatta 1596181 aaagagctga aaacggctgc gaaaaaagcc aaaaaagtgt atctcgcagc tgaccccgac 1596241 agagaagggg aagcgattgc atggcatttg gcacacagtc ttgatttaga tctcaactca 1596301 gactgccgtg tggtgtttaa cgaaattaca aaagacgcta ttaaggaatc gtttaagcat 1596361 ccccgcatga tcaatatgga tttagtggat gcacagcaag cgagacgtat tttagacagg 1596421 cttgtcggat ataaaatcag tccaatctta tggaaaaaag tcaaaaaagg gcttagcgca 1596481 ggacgcgtgc aatccgttgc cctccgtttg attattgacc gtgaaaaaga gattaacgac 1596541 tttaagcctg aggaatattg gacaattgac ggtacgttct taaaaggtca agaaaccttt 1596601 gaagcgagct ttttcgggaa aaacggcaaa aaacttcctt taaatagtga agctgatgta 1596661 aaagagattc tttctcagct caaagggaat caatatacag ttgaaaaagt aaccaaaaag 1596721 gaacgcaaac gtaatcctgc tttgcctttt accacttcta ccctgcagca ggaagcggct 1596781 cgcaagctca atttcagagc gaagaaaacg atgatgattg cacagcaatt atatgaagga 1596841 attgatttag gaagagaagg aacggttggt ctgatcacgt atatgagaac ggattcaacc 1596901 cgtatttcaa atacggctgt tgatgaagca gctgcattta ttgatcagac atatggaaaa 1596961 gagttcctag gcggaaaacg gaagcctgcg aaaaagaatg aaaatgccca ggatgcccac 1597021 gaagcaattc ggccgacatc agttcttaga aaaccaagtg aattaaaagc agtcctcggc 1597081 agagaccaaa tgagactgta taaattaatt tgggagcgtt ttgttgccag ccaaatggca 1597141 ccggctgttc tcgatacaat gagtgtcgac ctgacaaaca acggtttgac atttcgtgca 1597201 aatggaagta aagtcaagtt ttccgggttt atgaaggtgt atgttgaagg aaaagacgat 1597261 caaatggaag aaaaagaccg gatgctgcct gacttacaag aaggcgacac ggtattatca 1597321 aaagatatag aacctgagca gcattttacc cagccgcctc cgcgatatac tgaggcccgg 1597381 cttgttaaaa cccttgaaga acgcggtatc ggccgtccat ccacatatgc tccgacactt 1597441 gatactattc agcggcgcgg ctacgtggca ttggataata aacgtttcgt tccgactgaa 1597501 ttaggtcaga tcgttcttga cttgatcatg gagtttttcc ctgagatcat taacgttgag 1597561 tttacagcta aaatggagag agatcttgat catgttgaag aaggaaatac cgaatgggtc 1597621 aagattatcg ataatttcta caccgatttt gaaaaacgcg tcaaaaaagc cgaatcggaa 1597681 atgaaggaag ttgagattga accagagtat gctggagagg attgtgaatt gtgcagttct 1597741 ccaatggtat ataaaatggg acggtacggt aaattcttag cttgctccaa cttccctgac 1597801 tgccggaaca cgaaaccgat tgtgaaacaa atcggtgtga agtgcccgag ctgcggagaa 1597861 ggaaacattg ttgagcgaaa atcgaaaaag aaacgggtgt tttacggctg tgaccgttat 1597921 ccggactgtg aattcgtatc atgggacaaa ccaattgaac gaaaatgccc gaaatgcgga 1597981 aaaatgctcg tcgagaaaaa actcaaaaaa ggtatacaag tccaatgcgt ggaatgcgat 1598041 tataaggaag aaccacagaa gtagcggtga gcagggtctt gctcaccttc tttgtgtgtt 1598101 aaaagaaggc cttgaataat aaactaggag atgtgaaaga tgaaccaaca aacagtgaat 1598161 gtaatcggag ccggactcgc aggaagtgaa gcagcatggc agcttgccaa acgtgggatt 1598221 caagtcaaat tgtatgaaat gcggccagtt aaacaaacgc ctgcgcatca tacagataaa 1598281 tttgctgagc ttgtctgcag caactctctt cgctctaata cacttgctaa cgctgtcggt 1598341 gtattaaagg aagaaatgcg tgcgcttgat tcagccatta tcgctgcggc tgacgaatgt 1598401 tcggtgcctg ccgggggcgc tcttgcagta gaccgtcatg aatttgccgc aagtgtgaca 1598461 aatcgggtga aaaatcatcc aaacgtaacc gttattaatg aagaagtgac tgaaattcct 1598521 gaaggcccta ctatcatcgc aacgggtccg ttaacatctg aatcgctgtc tgcccagctg 1598581 aaggagctga ctggagagga ctatttatat ttttatgacg cagcggcgcc aattgtagaa 1598641 aaagacagcc ttgatatgga taaagtgtac ctgaaatccc gttatgataa aggtgaagca 1598701 gcatatttga actgcccgat gacagaagaa gagtttgacc gttttcatga agcattaaca 1598761 tcagcagaaa cagtgccgtt aaaagaattt gaaaaagaga ttttctttga aggctgcatg 1598821 ccgattgaag tcatggcaaa acggggtaag aaaacaatgc ttttcggtcc gatgaaacca 1598881 gttggtctag agcatcctgt tacaggaaaa cgcccttatg ccgtcgttca gctcagacag 1598941 gatgatgctg cgggaacact ttataatatt gtaggattcc agacacattt aaaatgggga 1599001 gaccaaaagg aagttctcaa gttgattcca ggacttgaaa atgtagaaat cgtcagatat 1599061 ggcgtgatgc atagaaacac atttattaac tctccaagcc tgttaaagcc gacttatcaa 1599121 tttaaaaacc gcagtgatct gttctttgca ggccaaatga cgggagtaga aggatatgtg 1599181 gaatcagctg cctcaggact tgtagcaggc attaatgcgg cgaagcttgt attgggagaa 1599241 gagcttgtga tcttccctca ggaaacagca attggcagta tggcacatta tattacaaca 1599301 acaaaccaga agaacttcca gccgatgaat gcaaactttg ggcttttgaa agaattgcca 1599361 gttaaaatta aaaataaaaa agaacgaaat gaacaatacg cgaaccgtgc gattgaaaca 1599421 attcaaacaa tttcgaaaac aatataggta ttgattgcaa cctgagcgcg atttgtgata 1599481 ccatttaaaa gcccttcctg gggaggtatt aggcatggag aatgttaaga atttcgtaaa 1599541 gttattcgtt gaatatttac aaattgaaaa aaattattca caatatacta ttgtgaatta 1599601 tgtggattca attgaagaat tcgagacttt cctgcgcgtt caaggtataa atggatttga 1599661 agaagctgca tatcaagata ctaggatttt tttgacagaa gcctatgaaa aaggtttatc 1599721 gagaagaaca ataagcaaaa agatatctgc attaagaagc ttttataagt ttctgatgcg 1599781 ggaaaagctt attgaagaaa atccgtttca gcttgttcat ctgccaaaac aggagaaacg 1599841 gataccgaag tttctatatc aaaaagagct tgaggagctg tttgaagttt cagatataag 1599901 ccagccggcc ggaatgaggg atcaagcgct gttagagctg ctctatgcca ctggaatgag 1599961 ggtcagtgaa tgctgttcca taactattaa cgacgttgat ttatttatgg acactgtgct 1600021 tgttcacggt aaaggcaaga agcagcgcta tatccccttt gggtcttatg cccgcgaagc 1600081 gttgaaggta tacatgaata gcggaagaca gtgcttgctg atgaaggcaa aagaacctca 1600141 tgatctatta ttcgtaaatc aaagaggcgg accgcttaca gcccgtggca tcagacatat 1600201 tttaagcggg cttgttcaaa aagcgtcaag cactttacat atccatccgc atatgcttcg 1600261 acatacgttc gccacgcatc tgttaaatga aggagcggat ttgagaagcg ttcaagaact 1600321 gctcgggcat tccaatctgt cttctacaca gatatacacg cacgtttcga aggaaatgtt 1600381 gagaaacaca tatatgtctc accatccaag agcatttaag aaaaattaaa ggaggccctt 1600441 tatgtcatct tttcatgcga ccacaatatt tgccgtacag cataaaggac gaagcgctat 1600501 gtccggagac ggccaagtaa catttggtca ggctgttgtc atgaaacaca cggcacggaa 1600561 agtgagaaaa ctgtttaacg gcaaagttct tgctggtttt gcgggatctg ttgcagacgc 1600621 tttcacttta ttcgaaaagt ttgaagctaa gcttgaagaa tataacggca acttaaaacg 1600681 ggcggctgtt gagcttgcaa aggaatggcg cagtgataaa gtgctaagaa agctcgaagc 1600741 catgctgatt gttatgaatc aggatacttt gcttctcgta tcgggaacag gcgaggtgat 1600801 cgaaccagat gacggcattc tcgcgattgg atcaggaggc aattacgctt tggcagcggg 1600861 aagagcactg aaaaagcatg ccggggaaag catgtctgca agtgagattg ccagagccgc 1600921 gttagaaaca gcaggcgaaa tttgtgttta cacgaacgat caaatcatac tggaagagct 1600981 tgaatagaaa ggacttgagg cgcatggaaa aaaaaccgtt aactcctaga cagattgtag 1601041 atcggttaga ccaatatatt gtcggtcagc aaaatgcgaa aaaagctgtc gccgtggcat 1601101 taagaaaccg ctatagaaga agtcttctgg atgaaaagct gaaggacgag gtcgttccga 1601161 aaaacatttt aatgatgggt cctaccggcg tcgggaaaac tgaaattgcc agacgaatcg 1601221 ctaagctttc aggtgcgcca tttatcaaaa ttgaagctac taaatttacc gaagtcggct 1601281 atgtaggcag agatgttgaa tcaatggtca gagatcttgt ggagacttct gttcggctta 1601341 taaaagaaga gaaaatgaat gaagtaaagg aacaggcaga agaaaatgca aacaaacgca 1601401 ttgttcgtct gttagttcct gggaagaaaa aacaatctgg tgttaaaaat ccgtttgaaa 1601461 tgttttttgg aggcagccag ccgaatggtg aagatgaggc ggagagccag gaagaagcaa 1601521 acatcgaaga aaaaagaaaa cgaatggcgc atcagctggc tttaggagag ctcgaagact 1601581 actatgtaac agtagaagtc gaagaacagc agccttctat gtttgacatg ctgcagggct 1601641 cgggtatgga gcagatgggt atgaacatgc aggatgcgct gagcggatta atgccaaaga 1601701 aaaagaagcg gcgcaaaatg acagtcagag aagccagaaa agtcctgacg aatgaagaag 1601761 caagcaaact catcgatatg gatgaagtcg gccaggaagc tgttcagaga gcagaagaga 1601821 gcgggattat ctttatcgat gagattgata aaatcgcaaa gaacggcggt gcatcttctt 1601881 ctgccgatgt ttcaagagaa ggtgttcagc gggatatcct tccgattgtt gaaggttcta 1601941 ccgttgtcac aaaatatggt tctgtaaaaa cagaccatgt attatttatt gcagcaggag 1602001 cgtttcatat ggccaaaccg tctgatttga ttcctgagct gcaggggcgt ttcccgattc 1602061 gtgtagaact gaacaaactc acggtagacg acttcgtgag aattttggtt gagccggata 1602121 atgcgctgct gaaacaatat caggcattat tgcagacaga aggtatatct cttgaatttt 1602181 ctgacgaagc tattcataag attgctgaag ttgcttatca tgtgaaccag gacacagata 1602241 atatcggtgc gagacgcctt catacaatac ttgaacgcct attagaagat ttgtcgtttg 1602301 aagctccaga tgtaacgatg gagaaaataa cgattacacc acagtatgtc gaagaaaagc 1602361 tcggaacgat agccaaaaac aaagatttaa gtcaatttat attgtgaaaa atttaatatg 1602421 aggaatgttt aggaggatta tttatcatgg ctttattaca aaaaacaaga attattaact 1602481 ccatgctgca agctgcggca gggaaaccgg taaacttcaa ggaaatggcg gagacgctgc 1602541 gggatgtaat tgattccaat attttcgttg taagccgcag agggaaactc cttgggtatt 1602601 caattaacca gcaaattgaa aatgatcgta tgaaaaaaat gcttgaggat cgtcaattcc 1602661 ctgaagaata tacgaaaaat ctgtttaatg tccctgaaac atcttctaac ttggatatta 1602721 atagtgaata tactgctttc cctgttgaga acagagacct gtttcaagct ggtttaacaa 1602781 caattgtgcc gatcatcgga ggcggggaaa gattaggaac acttattctt tcgcgtttac 1602841 aagatcaatt caatgacgat gacttaattc tagctgaata cggcgcaaca gttgtcggaa 1602901 tggaaatcct aagagaaaaa gcagaagaaa ttgaagagga agcaagaagc aaagctgtcg 1602961 tacaaatggc tatcagctcg ctttcttaca gtgagcttga agcaattgag cacatttttg 1603021 aggagcttga cggaaatgaa ggtcttcttg ttgcaagtaa aattgctgac cgtgtcggca 1603081 ttacccgttc tgttattgtg aacgcactca gaaagctgga gagcgccggt gttatcgagt 1603141 ctagatcatt aggaatgaaa ggtacttata tcaaggtact aaacaacaaa ttcctaattg 1603201 aattagaaaa tctaaaatct cattaatcac aaaaagaacc ctttttgagg gttctttttt 1603261 tatttcaaat aaaggaaatc aataagcttt atttcctggg ttgaaagtct ttctatgtaa 1603321 taattttaat aaattttgca tttttcttca aaaagtttca aaaatgccga aaagaaagga 1603381 gaaaaaacag aaattctgct attttcaggc ttatatcaag gcgagaaatg tagttctaac 1603441 aatctaggac tttataccta gttgcaaaat agataattgt gaggacattt ttttacacga 1603501 acttcataga ctttatgcct gttatttctt acaataagca tatagtttta caattctcga 1603561 caaggatatt gagggtgaaa aaaactgaaa tggaggtaag tggatttgag cttattttct 1603621 ggaacgatac aaaatcttga aaatgccttg agcagagcgg atattaagca aaaagtcata 1603681 actaataata tcgccaatat agatacaccg aactataagg caaaaaaagt ctctttccaa 1603741 aatttattag atcaagaatc ctcgcgtctt gaagcgataa aaacagacta tcgtcatgtt 1603801 gatttttctg atactgattc gaattattca attgttgcga gcggagatac atcgtatcag 1603861 caaaacggaa acaatgttga tgttgacaaa gagatgacag aattggcgca aaatcaaatc 1603921 aactatcaag ctttggttga aagaatgaac ggtaaattta attcgctgaa gaccgtatta 1603981 acaggaggaa aatgatgaca gcttttcata gcttaaatgt ttcagcatcg gctttaacag 1604041 ctcagcgagt cagaatggac gttgtatcat ctaacttagc aaatatggat acgacaagag 1604101 ctaagcaggt gaatggagag tgggtgcctt acagaagaaa aatggtttcc cttcagtcaa 1604161 aaggtgaatc gttctcttcc attctcaatt ctcaaatgag cggaagcggg aatgctggaa 1604221 acggtgtgaa ggtttcaaaa attacggagg atgattcgga ttttaatctt gtctatgatc 1604281 cgacagaccc tgatgcaaac gctgaaggat atgtacaaaa gcctaatgtt gatccattaa 1604341 aggaaatggt tgatcttgtc agcagcacta gatcatacga ggcgaatgtc acggcgatga 1604401 atgccacaaa gggaatgctg atgaaggcgt tagaaatcgg aaagtaggtg aatgaatgtg 1604461 attaatgcaa tttctccttt tcaggttcaa aatactcaaa acactcaaaa tgcaacaaat 1604521 caagtaaaca atagccaaaa aacagattct tcaaatcaaa caagcttttc ggagctttta 1604581 aaaaactcta ttagttcgtt aaatgagtcc caagtagctt ctgacaacat gactaatgcc 1604641 ttggctgcag gaaaagatgt aaatcttgat gaggtcatga tcgctgctca aaaagctagc 1604701 atctctctaa ctgcagcaac agagttccgc aataaagctg tggaagctta tcaggagatt 1604761 atgagaatgc aaatgtaggg ggtctgacga tttagagaaa gagtggaatg accgggggtt 1604821 aacatgaatc gtactctaat gcaaatgaaa aacaaaacga gtgagttttg gaaaaataga 1604881 tctaaattac aaaagatttt aatggttagt gctttagcgg caattattat tattggaatt 1604941 attattagtg tttttgcttc aaattctaaa atggcgccgc tgtacaaaga tttgtctgcc 1605001 gaagaagcag gacaaatcaa agaagaattg gatgcaaaaa aagtgccaaa cgaactttcg 1605061 aatggcggta cagtgattag tgttccggag gatcaggttg attctttgaa agtgcagatg 1605121 gctgcagaag gacttcctaa aacgggatca attgattatt cgttttttgg acagaatgcc 1605181 ggctttggtt tgacagacaa tgagtttgat atggtgaaag tgaaagctac acagacagaa 1605241 ctgtcaaact tgatcaatga aatggacggt attaaaaatt caaaagtaat gattaatctc 1605301 ccgaaagacg ctgtgtttgt cggtgaagag caatctgcag catctgcatc aatcgttttg 1605361 cagattcaac cgggttatac acttgatcaa agccaaatca acggattata tcatctggta 1605421 tctaaaagcg tgccaaacct aaaagaagat aacatcgtca tcatggacca aaattctaca 1605481 tactacgaca aatcagacag cgatgcaggg tcctacgcgg atagttattc ttctcagcaa 1605541 ggaattaagt ctcaagttga aaaagacatt caaaaacatg tacagtcact gctgggtacg 1605601 atgatgggcc aagataaagt cgttgtctcc gttacagcag acattgattt cacaaaagaa 1605661 aatcggacag aagacattgt cgaacctgtg gataaagaaa acatggaagg cattgcagtc 1605721 agcgctgaaa aggtatctga aacatatcag ggcgacggtg cagccaacgg cggaactgcc 1605781 ggaaccggcg aggaagatgt tacaaattat aaggctgacg gtgaaaatac cgaaagcggg 1605841 aactacgaaa aaaacagcaa caaaatcaat tacgaggtta accgaattca taaagaaatc 1605901 gctgaaagtc cttataaggt cagagattta gggattcaag taatggtaga gccgcctgat 1605961 gccaaaaaca ctgcgtcgct atcaactgaa agacaggatg atatacaaaa aatcctttca 1606021 actgtagtca gaacatcttt ggataaagat gaaacgcaaa atcagaattt atctgatgct 1606081 gatatcaata ataagattgt tgtttccgtt cagccattcg acggaaaagt caatttggat 1606141 acaaatacgg aagaatcctc aggtatcccg ctgtgggcat atattgtagg cggtgtttta 1606201 atcgcagcga tcattgttct gatcattatg cttatcagaa agaaacgggc gcaagaggat 1606261 gaatttgagg aatatgagta tgaggttcct caagaaccaa tcaatttgcc tgatatcaac 1606321 gaagaggaaa atgaaacagc ggaatcagtc agacgaaaac agcttgaaaa gatggcgaaa 1606381 gacaagccgg aagattttgc aaaactgctg agaagctggc tggccgagga ttaggaggaa 1606441 ttagaaatgg cgagacgtga tcaagataag cttacaggaa aacaaaaagc agccattctc 1606501 atgatttcct tggggttaga tgtgtcagct tctgtctata agcacttaac cgatgaagaa 1606561 attgaaaggc ttactctgga aatatcaggt gttcgaagcg tcgatcatca aaaaaaggat 1606621 gaaatcatag aagaatttca taatatagcc attgcgcaag attatatttc tcaaggcggt 1606681 ttaagctatg caagacaagt tctggaaaag gcgcttggag aggataaggc ggagaacatt 1606741 ctaaacaggc tgacttcttc tttgcaggtt aaaccatttg attttgccag aaaagcggag 1606801 ccagaacaaa ttttgaattt tatccagcaa gagcatccgc agacgatggc gttaatcttg 1606861 tcttatttag atccagtgca ggccgggcaa attttatccg agctgaaccc tgaagtgcag 1606921 gctgaggttg cgagaagaat cgcggtcatg gatagaacgt ctccagaaat aattaacgag 1606981 gtagaacgga ttctggaaca aaaattatct tctgcattta ctcaggatta tacacaaaca 1607041 ggcggaattg aagctgttgt ggaagtgtta aacggggtag acagagggac agagaagacg 1607101 atcttggatt cattggaaat tcaggatccc gatcttgctg aagagattaa aaagcggatg 1607161 tttgtcttcg aagatattgt cacacttgat aaccgtgcaa ttcagagagt cattcgcgat 1607221 gttgagaacg acgatttgct cctttcatta aaggttgcaa gcgaggaagt caaagaaatt 1607281 gtgttcaaca atatgtcaca gcgtatggtt gaaaccttca aagaagaaat ggagtttatg 1607341 ggccctgtac gtttgaaaga tgtagaagaa gctcaatcaa gaattgtaag catcgtcaga 1607401 aagcttgaag aagccggtga aattgtaata gcaagaggcg gaggggatga tattattgtc 1607461 taatatcatt aaacaagaat catctatttc tccacaaaag gaaaaaagaa aactttctat 1607521 acaagaggtg cgtattgatc attctcacct tttgcaggct gaagagaacc cggaggcgct 1607581 tatggcccga gtgaaagagg aagctgaccg gatttctgag caggcaaaca gtcatataga 1607641 aaatattcgc cgtcaaattg aacaggagaa aaacgattgg gcggctgaaa aacagaagct 1607701 tattgaagaa gcaaaagccg agggctttga acaaggagta gcgctgggca aagctgaggc 1607761 aatgaaacag tatgcagaac tgatcggcca agcaaacagt ataactgaaa tgtccagaaa 1607821 agctgttgag gacaagcttg aagacgctaa tgaagaaatc gttgagcttg ccgttgccct 1607881 agcaaaaaaa gtttggcagc aaaagtctga tgataaagag gctttcctcc tgcttgtaca 1607941 acaggttata aacgaagtga aggaatatga cgatatatca atttatgttg atccatatta 1608001 ctatgagaca atctttcagc aaaaagatga aatccagcag cttctttata aagaatgtcg 1608061 gcttggcata tatgctgatg aaaaagctca aaaaggaacc tgttatattg aaactccttt 1608121 tggcagggta gatgcgagtg ttgacacaca attgatgcaa ttgaaagata aacttctgac 1608181 agcgctggaa gcaggtgcag ctgaatgaag acacagagtc tgatagattg tatagaaatg 1608241 acagactcgt ataaacggta cggaaaagtc aagcgggtaa tcggcttgat gattgaatca 1608301 aaagggccag caagctcaat tggtgacctg tgcctgattt atgcaaaagg acagtctggg 1608361 aaagtcatta aagctgaggt agtcggcttc caggaagaaa atattttgct tatgccttat 1608421 ttagaggctg cgagcattgc acctggcagc attgtagaag ctactgggga atcacttcgg 1608481 gttaaagttg ggaccggact gatcggacaa gtcatcgatg cttttggaga accgcttgac 1608541 ggaaagcttc tgccgaaagg gctttcgcct gtatcaacgg agcaatcacc gcctaacccg 1608601 atgaaacggc cgcctatccg tgaaaagatg ggtgttggag tcagatcaat tgacagcttg 1608661 ctgacagtcg gtaaaggcca gcggattgga atttttgcag gaagcggtgt cggaaaaagc 1608721 accttaatgg ggatgatcgc caagcagaca gaggctgact taaacgtcat tgcacttgtc 1608781 ggagaacgcg gacgagaggt tcgggagttt attgaaaaag atctggggaa agaggggctg 1608841 aaacgatcga ttgtagtcgt tgccacctca gaccagccag cattaatgag attgaaagcg 1608901 gcatatacag cgactgcaat tgccgagtat ttccgagata aaggccaaaa tgtcatgttt 1608961 atgatggatt ctgttacaag ggtggcaatg gcgcagcgag agattggact ggctgcagga 1609021 gagcctccga cgacaaaagg ctatacacct tcagtgttcg ctattttacc tcgtttacta 1609081 gaacgaacag gtgcaaacga gcatggaacc attacggcat tttatacagt gttggtagat 1609141 ggggatgaca tgaatgagcc gattgccgat accgtacgcg gaattttaga cgggcatatt 1609201 gtgttggaca gggcgcttgc caataaaggc cagtttcctg cagttaacgt actaaaaagc 1609261 atcagcaggg tgatgtcaaa catttcaaca aaacagcatc tggatgcggc aaataaattc 1609321 cgtgaacttt tatcgacata tcaaaattcg gaagatctca ttaatatcgg agcttacaaa 1609381 agaggatcat ccagagaaat tgatgaagcg atacaatttt atccgcagct tattcaattt 1609441 ttaaagcagg gaacagacga accggcttta ttggaagaaa gcattgctgc attaactagt 1609501 ttgacaggaa atgaggaata aacgtggctt atcaatttag attccaaaag ctgctggaac 1609561 taaaagaaaa tgaaaaagac caatccttat ccgaatatca gcaatcagtt tctgaatttg 1609621 aaaacgttgc tgaaaaatta tatgagaata tgagcaaaaa ggaattgctg gaacaaaata 1609681 aggaaaagaa attaaaaagc ggcatgagtg tacaagaaat gaggcactac caacaatttg 1609741 tctcaaatct tgataatacg atctatcact atcaaaagct tgtcattatg aaaagaaatc 1609801 aaatgaatca aaaacaagaa attttgacag agaaaaacat tgaagtgaaa aagtttgaaa 1609861 aaatgcgtga aaaacagttt aaaatgtttg ctcttgaaga taaagctgca gaaatgaaag 1609921 aaatggacga tatttcgatt aagcagttta tgattcaagg ccattaggag cgaatgtaat 1609981 gtccggcaaa aagaaagaat caggtaagtt ccgttcggtt ttgcttatca ttatcctccc 1610041 gctgatgttt ctattaatcg caggggggat tgttctttgg gctgctggta tcaatgtctt 1610101 aaagccgata caggatgctg cggcaaaaac gccggttctt aaagaattgg tccctgaaac 1610161 cgaaaataaa aaaggcgcag catcaagtaa ggatagcagt aatacggcag ctctggaaaa 1610221 gaccattaag gatcaaaaaa gtgaaatcag tatattgaat aaagatttag aaacaagtaa 1610281 atcagaaatc gacaggctca atcaaaagat ccgttcactt gaaaagacgg ctgaggatca 1610341 aaaaaagtca tcagaagatc atactgaagg atcagcagac tcgaaagctt cttctgaaaa 1610401 tgacaaagtg atcagtgtgt acaaaagcat ggacagcgga aaggctgcta aaattattgc 1610461 ccaattaaag gagcaagaag cactgaaaat attgaatggc ctaagcaaaa agcagcttgc 1610521 tgacatattg gcgaaaatga ctcctgagca agcagcaacc tatacagaaa aaattgctgc 1610581 cagccaagaa tagggggaat gaaaggtgaa gctgcttgaa ttagccggac ctttgctgca 1610641 aaccacaacg ggttctgccg ctaaaaacat gaaaagtagc cagggagttt ttcaaaactg 1610701 gcttatgtct gaggctggat tgaaggaact ttcagaacaa ggaaagggaa ctcctaattc 1610761 tgaagatcag cttttagcag atgcgcttaa aaagatcggt gaatggctaa atgcaagtcc 1610821 tgaagatcaa gacaaacaaa atgcggatct tttgcaaaca ttaagcaaac tgacagggaa 1610881 gcaattggat gcgaatgctc tgcaaatgtt gcaaaatctt ttgcaagcag ttgaatcaaa 1610941 aatgtcaggc gggacggatc aattgctcac agaaacggag aaaatctttt cagaagctaa 1611001 aacggctctg agtgccaatg attctgcttc tgacattaat ggagcactga agtctgataa 1611061 agagcaatca aatcaggaaa atgaagtatc cgagcctgca aaagagctta tctatatcca 1611121 gatgttcatt agccagctcg tagaagggaa taagctgact gatctcggga atggcaatga 1611181 agctcatgcc atttaccaaa atggagatca attcctttct gcattagaaa agaagggtgt 1611241 atctcaacaa ctaattcagg atcttaaaca gcaaatattc actaaagctg agtcaagttc 1611301 aaaactttac tcgatgacag cgtcagagct gaaaagtttt caaagcttaa tggatcaaat 1611361 gtctatgctt cctcaaaaag ggaccaaaga atggagttta gctgaaagcc agctgaaagc 1611421 cttcttgtta tcgaaatcat ccgaatcatc acaagacttt gggaagagtg ttctcacacc 1611481 gctctcgcag agttcatcca gcaaaaatgc atcggatgtt tctggaagta ttcagcctgt 1611541 agatagtaaa tcaggactcc aaatgctgtt ttcggggtat cggggcatag gaggagttca 1611601 aacacttgat ctgcagcaga tgtcatctga tataccaaat gccgaaacaa aaacggtggc 1611661 tgatcaagtg attaatgcgt ggaagcagat gaaatatacg cctttcggca gatcgacggg 1611721 aagtttcact attcggctga accctgaaca tttaggattt gtcacaatca agctgacaaa 1611781 tgaaaatgga atgtttcaga gtaaaatcat agcatctagc caatcagcaa aagaattgct 1611841 tgaacagcat cttcctcagc tgaagcaatc attgccgaat atggccgtcc aaattgaccg 1611901 ttttactctt ccggtccaaa gcggggatca gccgatatac ggccagcttg ctgatgaaca 1611961 gaaacagcag caagaggggc agagacagca aagacagaaa aagcaatcaa atgattttgg 1612021 cgatctgctc gatgaagtgt cgatggttga aatggaggaa gaagaatgac ttctataagt 1612081 tcagaatata aactgcctga aaaaacgaac actgtgtcga cgaacaacag cagcttgggg 1612141 aaagacgagt ttttaaaaat attaatgact caagttcaaa accaagatcc gcttaacccg 1612201 attgacgata aagaatttat cagccagatg gcgacttttt caagcttgga gcaaatgatg 1612261 aatctgaata cgacaatgac tcaattcgtt gaaaaccaag atccgtttac aacgtatgtt 1612321 gattggatgg gaaaagaagt atcttggact gatggtaaaa gtgcaacaga taaaacaggc 1612381 acagtaagct ctgttaaaca ttttaaagga aattattatc tcgttcttga tgatgggacc 1612441 gagatcagtc ctgcgaatgt catgtctgtg ggacaatcat ctaaataaaa acatctgggg 1612501 gaatatatta tgttacgttc actttattct ggaatcagcg gtatgaaaaa ctttcaaaca 1612561 aagcttgacg taatcggtaa caacattgcc aacgtaaata cagtaggatt caaaaagagc 1612621 cgtgtgacct ttaaagatat ggtaagccaa acgattgccg gcggttctgc tgctggtgca 1612681 acaatcggcg gaacaaactc taagcaaatc ggtttaggtt catcatctgg cacaattgat 1612741 acaattcatt caacaagcgc gacacaaagc acaggaagaa cacttgattt agcaattgac 1612801 ggcgacggtt acttccgaat tgatacaggt gacgggacag cttatacaag agcagggaac 1612861 ttctatttag ataatactgg aacactggtt acaggtgatg gctaccatgt actaaatatg 1612921 aatggcggaa caattaaaat tcctactgat gctcaaagct ttagcattgg ttctgatgga 1612981 aaggtgtcaa ttgttgatgc tgaggggaaa acacaagacg ggggacaaat cgggattgtt 1613041 acttttgcca acagtgatgg attggataaa atcggaagca acctataccg tgaatcttta 1613101 aactctggaa cggccagtgc agcgaaccag cctggtgacg gcggaactgg tgctcttaaa 1613161 tcaggatttc tcgaaatgtc taacgtcgat ttaactgacg aatttactga aatgatcgta 1613221 gcccagcgcg gattccaatc aaactcaaaa attattacaa catctgatga aatccttcaa 1613281 gaactggtta accttaaacg ttaaggaggg aggggaggcg agtaatcgct tctccgctgt 1613341 tttatgatta aagtaacccg tttgaacggg cagcccttta cactgaatgc gctatttatt 1613401 gaacagattg aatgttttcc ggatactaca attactctgt caaatggtaa gaagtttgta 1613461 gtaaaagaag atgaagaagc tgttctggaa aagatcgcag ctttctaccg aaaaatacaa 1613521 atatttgcaa tggatcaagg aatagaggaa ccggaatgaa gaaaaagtta atgatcatat 1613581 tactaattat tcttatcgta attggtgctc tcggggcggc ggcttatttt gttttaggcg 1613641 gaaagtccga aaaaagtgaa gcgaaaaaaa gtattgatga aatcgttgcg tcttctgttg 1613701 atgtagaaga gatcacaaca aatttaaagt ctgataacat tatccgtctt gctattaaac 1613761 ttgaaactga ttctgataaa tcaaaagaag aacttgagaa acgtgatttc caagtgaaag 1613821 acgctgttat atcactgctg gctgatacga atgctgatca gattgaggga gacaagggaa 1613881 aagaaacctt taagaaggaa ctaaaagata aaataaatag ctacctccaa gaaggaaaag 1613941 tagaaaaagt gtatattacc tcctttaatc tgcaataaag cataatttga cagaatacgg 1614001 aggtgaggaa aatgtcagga gaagttctct cccaaaatga aatagatgca ctgctctctg 1614061 caatatcaac tggtgaaatg gacgctgaag agctgaaaaa agaagaaaaa gagaagaaag 1614121 tcaaggttta tgatttcaaa cgtgcgctgc ggttttctaa ggatcagatc cgcagtttaa 1614181 cgagaattca tgacaatttt gcaagacttc ttaccactca tttttctgct cagctcagaa 1614241 cctatattca catatctgtc agttctgttg atcaggttcc gtatgaggaa tttatcagat 1614301 cgattccaaa catgacgatt ctgaatctat ttgatgttca tccgatggaa ggaagaatta 1614361 tgatggaggt caaccccacg atagcttata cgatgatgga tcgagtcatg ggcgggattg 1614421 gaatcagtca taacaaggtt gacagtttga cagaaattga aacaaaaatc atttctaatt 1614481 tatttgaaaa tgcactgggt aattataaag aagcttggca gtcaattgct gatattgaac 1614541 cggaaatgac tgagtttgaa gtgaatccgc aatttgttca gatggtatct cctaatgaaa 1614601 cagtcgtggt gatctcgctc aatactcaaa ttggtgaaat cagcggtgtc attaatctct 1614661 gtatcccgca tattgtactc gagccgctca taccgaagct ttcagtccac tattggatgc 1614721 aatcagaccg aaatgagcca aagcctgagg aaacaaagtc gcttgaaaaa cgtatcatga 1614781 cagcacaaat acctgtcgtg gccgagctcg gcacatctga actgacgata gaagagtttt 1614841 taagtttaga agtcggagac tgcataactt tggacaaatc agtcacggat cctcttactg 1614901 tattggtcgg agataagccg aaatttttag gacaagccgg ccgggtgaat cgaaaacagg 1614961 cagtgcaaat tttagatcac gacataagag gtgaacaaga tggagaataa tagattatct 1615021 caagatgaga ttgacgcgct tcttaacggt actggcagca cgcttgatga gccagagatt 1615081 ccggaagtag atgacttatc ggaaatggag cgtgatgcga tcggtgaaat cggtaatatt 1615141 tcattcggca gttctgcgac agcactgtca acgcttttaa atcaaaaggt cgatattacg 1615201 actccaagcg taacggtcat tccaagaagt aaaatcagcg atgcgtttcc tgaaccgtat 1615261 gtagcgattg aagtgaatta tacggagggc ttcagcggaa gcaacctgtt agtcgtggaa 1615321 caaagtgacg cggcgatcat tgcggactta atgatcgggg gagacggaaa aggtgcggac 1615381 ccttcactgg gtgaaatcca tttaagtgcg gttcaagaag caatgaacca aatgatggga 1615441 tcggctgcca catcaatgtc tactgtattc agtaaaaaaa ttgatatttc acctcctcgg 1615501 gttgaattgc tggatgttac tgaagaaaag ggtacagacc gtattcctga tgatgaaatg 1615561 ctggtgaaag tttctttcaa cttaaaggtg ggagaattaa tagactccag cattatgcaa 1615621 ctttacccat tgacatttgc gaaagattta atttcaagcc ttatgaactc agaaagtgca 1615681 gaggaagaag aaacggtgca gcctgaagtt acatacgaac agccgaaaga gcctgtgacg 1615741 ccagagccgc gtattgaacc gaagcaacag cagcagccgc caaaaaggca gggaacagca 1615801 aaaaaagcag cgccagttca ggtttcaccg gtggaatttt ccgcgtttga tccaaacgaa 1615861 gctgtacaag cccctattca taatctggat atgcttttgg atatcccgct ttcgattact 1615921 gttgagcttg gcagaacgaa gagaagcgta aaagagattt tagagctttc tgccggaagt 1615981 attatcgagc ttgataaatt agccggtgag cctgtagata ttttagttaa tcagcgtatc 1616041 gttgccaaag gcgaggtcgt tgtcattgaa gaaaacttcg gagtgagagt cactgacatt 1616101 ttaagccagg cagagcgcat taataattta aaataacgaa acacaaggag agagatagat 1616161 tatggcacat agaattttaa ttgtagatga cgcagcattt atgcgaatga tgattaaaga 1616221 tattttggtt aaaaatggtt ttgaagttgt ggcggaagct gaaaatggag cacaagcggt 1616281 agagaaatat aaagagcatt cacctgacct tgttactatg gatatcacga tgccagaaat 1616341 ggatggtatt acagcattaa aagaaattaa acaaattgat gcgcaggcaa gaatcatcat 1616401 gtgttctgct atgggacagc aatcaatggt tattgatgcc attcaggccg gcgctaagga 1616461 tttcattgtg aaacctttcc aggctgaccg tgtgcttgaa gcaatcaaca aaacattaaa 1616521 ttaaagggtg tacgactgtt gaaaaagagt caatatttta ttgtttttat ttgttttttc 1616581 gttttattca gtgtacatcc gattgctgct gccgcggcag actctgataa ttcaactgta 1616641 aacgaatggt ttcaaaagaa agatgaaaaa actgcagatc aatcagagca aaagaaagaa 1616701 aaaacaacaa aaactgctga tgagacggag ggagcggctg ctccttctgt ctcagctttt 1616761 gattttgtaa agatgatttt cgctttactg tttgttatcg tgctgattta cgggctggtt 1616821 aagctcatga acaaaagaaa tcggctccta aagccttttc aatatgttga aaatattggc 1616881 ggcacatcgg tcggtcagaa cagatccata caattgatca aggtcgggaa aagtgtgctc 1616941 gtcgtcggtg taggagagac gatccagctg ctgaaagaaa ttgaggatga aaaagagatt 1617001 gaagtcattc tcagtcagca tgaagaggca atgtcaagca aaatagagtg gcaaaagttt 1617061 gtgaagccgc ttaagagttc tgaacatcag ccgcagcaaa aactgccttc attttcaaaa 1617121 gcattaaaag agcaacttga agagttaaaa caaaaccgtt ctgaaggaaa gaagaaaggc 1617181 ccacgtcatc atgaatgagt ttataaatat tttcagttca agcgatccgg aaaacgtaag 1617241 ttcgactgtt aaattactat tattgttaac tgtattttca gtggcgcctg gaatattgat 1617301 tcttatgact tgttttactc gcatcgtcat tgttctgtca tttgtcagaa cttcacttgc 1617361 gacgcaatct atgcccccaa accaggttct aatcgggctt gcgctgtttt taacattttt 1617421 tattatggct cctacttttt cagaaattaa taaagaagcg ctgaccccat taatggacaa 1617481 caaaatcagc ttggatgaag cgtatacgaa agctgaggaa ccgattaaag aatttatgag 1617541 taaacacaca aggcagaagg atctggcgct gtttatgaat tacgcgaaaa tggataaacc 1617601 tgaatcatta aaggatattc cgttaacaac aatggttccg gcttttgcca tatcggagct 1617661 taaaacagca tttcaaatag gttttatgat ttttatccct tttttaatta tagatatggt 1617721 agtggcgagc gtcttgatgt caatgggaat gatgatgctg cctccagtta tgatttctct 1617781 gccctttaaa atattacttt ttgttttggt agacggctgg tatttaattg tgaaatcttt 1617841 gcttcagagc ttttagggta ggtgctaaac gtgagttcag aatttgtaat ttctatggcg 1617901 gaaaaagccg tatacgtaac gctgatgatc agcgggccat tattggctat tgctttactg 1617961 gtcggtttaa ttgtcagcat atttcaggcg acaactcaaa tccaggaaca gactttggcg 1618021 tttattccga aaatcgtggc ggttctcctg gctctcattt tttttggtcc gtggatgctg 1618081 tcgacgattc tttcatttac aacagagctg ttttctaatt taaatcgttt tgcagggtaa 1618141 tgtagagatg aattcaatta ttgacttatt tcctgctttt ttattggttt ttattagaat 1618201 ctctgctttt tttgtaacga ttccgctatt tggacatcga aatgtgccag ctgttcatcg 1618261 cataggtttt gctttttttc ttgcggtcat ttgtttcagc accattgata aaccgccctc 1618321 tttggagata gatgagcact atatgctttt ggcgtttaaa gaagctttgg tcggcctatg 1618381 tctgggttta attgcttata tgatgattgc cgcagtgcag attgccggct cgtttattga 1618441 ttttcaaatg ggattttcaa tagcaaacgt tattgatccg caaaccggtg cacaaagtcc 1618501 gttgattggc cagtttatct atacgatggc acttttgttt atgctgagtg tcaatgccca 1618561 ccatttgttg ctggatggta tttactacag ctttcagtat atttcagttg atcaggcatt 1618621 tccgaatttc ggcgatgaaa agtttgccta ttttattgcg aaaagcttta atgcaatgtt 1618681 tattatcgct tttcaaatgt cagcgccggt tgtggccagt ttgtttctag ttgatttagc 1618741 attaggtatc gtggctcgaa ctgttccgca gttaaatgta tttgtggtcg gtctgccttt 1618801 aaagatcgct gtcagtttca ttatgctcat tgtatgtatg tccgttatct tcgtcgttgt 1618861 ccggaatgtt ttcagtttaa cgattgaaac gatgcggaat cttttagcat tggtcggtgt 1618921 ttcttaatga agcttagagt tgacctgcag ttttttgcgg gagagaagac agaaaaagcc 1618981 actccgaaaa aacggaagga tacgcgaaaa aaagggcagg tagccaaaag ctcggatgtc 1619041 aataccgccg tttctttact ggtaatattc ctttcgctta ttgcaattgg tccgtatatg 1619101 agagacaggc tgctgtcatt catagaaaca ttttataccg aatcgctcac aatgaagctc 1619161 tcagaatcaa atgtgcatac attgtttgtc agcttattaa aggatatggg catgatactc 1619221 gcaccgatct tgcttgttgc tcttgttgca ggagtcgtaa gcaactatat gcaggttggg 1619281 ttcttgtttt ctgctgaagt gatacagcct aagcttgaaa aactggatcc gatcaaaggc 1619341 tttaaacgaa tatacagtat gagggcgatt gtagagctga ttaaatcaat tttgaaaatc 1619401 gtagtcgtcg gttttgcggc ttttgctgtg ctttggctgc attatggaga aattctccgg 1619461 cttcctctcc tgacacccga agaggcactt tctttcgttt caaaactcac tttgtggatg 1619521 ggactaagcg gtgcaggtgc attgttgatt cttgctggtc tcgactattt atatcagaga 1619581 tttgactatg agaaaaatat caaaatgtca aaacaagata taaaagatga gtacaaaaaa 1619641 tctgaaggag acccgattat caagtctaaa attaaacaaa gacagcggga aatggcgatg 1619701 aggcggatga tgcaggaagt tccaaaagca gatgtcatta tcacaaaccc gactcactat 1619761 gcgattgctt tgaaatatga tgaagaaaaa atggacgcac cttatattgt tgcaaaaggc 1619821 gtcgaccacc ttgcgttaaa aatcaggaaa attgctaaag agcatgatgt catgatggta 1619881 gaaaacagac cgcttgcccg tgcgttatat gatcaagtgg aaattgacca ggcagtgccg 1619941 gaagaatttt ttaaagtttt agcagaaatt ctggcttacg tatataaaac aaaacaaaaa 1620001 gtatattgaa tttttcgatt taaaaggaga gaaaaaacag catgtcaaca agagatttat 1620061 ccgttttaat aagtgttgtc ctcattgtgg cgatgctggt gattccattt cctccatggc 1620121 tgttaagtat tttgatcatt attaatattt ctcttgcgtt gatcgtgctt ctcaccacaa 1620181 tgaatatgca ggaagcgctt cagttttcga tttttccgtc actgttgctg cttttgaccc 1620241 tatttcgttt gggcttgaac gtctcaacta cccgttcaat tctttcacac ggtgagggag 1620301 gtaaagtcgt cgagactttc ggaaatttcg ttgtcggcgg aaatgtatta gttggactcg 1620361 ttgtatttat catccttatt attattcagt ttatcgtcat tacaaaaggt gctgaacgtg 1620421 tttccgaggt tgcagcaagg tttacgctgg acgcaatgcc ggggaagcag atgagtattg 1620481 atgctgattt aaacgcaggg atgattaccg aacaggaagc gaagcatcgc cgcgaaaaag 1620541 tggcaagaga agcagacttt tatggagcaa tggacggtgc cagtaaattt gtaaaaggtg 1620601 acgccattgc cggaatcatc attgtgatga tcaatattat tttcggaatc gtgatcggaa 1620661 tgcttcagca gggcatgtcc attcaagaag ctgcttcaca ctttacgatg ctgactgtag 1620721 gggatggaat tgtttcgcaa atcccggcac tgttaatttc tacggctacg ggtattgtgg 1620781 tcacaagagc tgcatctgaa ggaaacttag ggcatgacat tacaggccag ctgtttgcgt 1620841 atccaaagct tttatacgtc gcagcagcta cgatcatgct tttaggtatt ttcactccga 1620901 tcggcatcct tctgacgggg ccgcttgcgg gattgcttgc ttttggcgca tatacactat 1620961 ctaaatcagg taaggaaaaa gaagaagtgg atgagattct tgaggaagag gctgaggtgg 1621021 acgagcttaa aagccctgaa agtgttgttc agcttctgca tatagatccg atagaatttg 1621081 agtttggata tggcctgata ccgcttgctg atgccaatca aggcggtgat ttattagacc 1621141 gaattgttat gatacgccgt cagttggctt tggaactcgg gcttgtcatt cctgtcgtgc 1621201 gaatcagaga taatatagcg ttgcagccta atgaataccg attgaaaatt aaaggaaacg 1621261 aagtagcaaa aggcgagctg ttgcttgatc attatttagc gatgtcgcct actcctgagg 1621321 acgatctcat tgaagggatt gaaacagtgg agccttcatt cggactgccg gctaaatgga 1621381 ttagcgaagc ggtaaaggat gaagccgaca tgcttggtta tacagtagtt gatcctgcat 1621441 cagtcgtttc aacgcatatt acggagaaaa ttaagcagca tgcccacgaa ttgatcggaa 1621501 ggcaggagac aaaacagctg atcgatcact tgaaagaatc gtatccagtc ctggttgaag 1621561 aggttacgcc gaatccattg tctgtcggtg atattcagaa agtgcttgct aagcttttaa 1621621 aagaaaaagt ttcaattcga aacttagtaa cgatttttga aacacttgct gactatggga 1621681 aattaacaac agattctgat ctcttgacag agtatacaag acaagcgctt gctaaacaaa 1621741 ttacagccca gtttgccaaa gaaaatgaag tgttgaaggt tgttacttgt tccggccgtg 1621801 tagaaaaagc aatagcagac ggtgtgcagc agacggaaca cgggaactat ttatcacttg 1621861 aaccagatat ttcagaaagt atagtgcgct ctgtcgccaa agaagctgaa cagctctcat 1621921 tacgtcagga aaccgcgatt cttctttgct cgccgcctgt cagaatgtat gtgaagcagc 1621981 tactggaacg gtacttccct gatcttccgg tactctctta taacgaactt gaggcgaatg 1622041 ttgaggtaca aagcattgga gtggtggata tttaatgaaa ataaaaaaat ttactgctgc 1622101 ttcaatgcaa gaagcggcac ttctcatcag aaaagagtta ggtaatgaag cggtcatatt 1622161 aaattcgaaa aaaattaaaa agcgaaaatg gtttggcctc gtcaacaagc ctgctgttga 1622221 agtaatcgcc gtattggatc aggactttct tgagaaaaaa acgcctcaga aggcagctga 1622281 accgaaacaa acattaaaaa ctccggtcag cagtccaaaa atagaggaga gaacatatcc 1622341 ccctcaaatt ccggcgcaac aggagctagg tgatttttca gcatatcaat ctgtacttcc 1622401 tgagccgctg cgaaaagcag aaaagctttt gcaagaaaca gggatcaaag agtctacgaa 1622461 aacgaacact ctgaaaaaat tgcttcgctt ctctgttgaa gcaggcggct tgactgaaga 1622521 aaatgttgtc ggcaaacttc aggaaatact atgcgatatg ctgccctcag cagacaagtg 1622581 gcaggagcca attcattcaa aatatatcgt tctctttggt tcaacagggg ctggtaaaac 1622641 aactacactg gctaaactcg cagccatatc tatgcttgaa aaacataaaa aaatcgcttt 1622701 tattacaaca gatacgtatc gtattgcagc tgttgaacag ttgaaaacat acgctgaact 1622761 gctgcaggct cctctggaag tttgctatac aaaagaagaa tttcagcagg cgaaggagct 1622821 attttctgag tatgatcatg tgtttgttga tacagctgga agaaacttca aagacccgca 1622881 atacattgat gaactgaaag aaacgattcc ttttgagagc agcattcagt catttcttgt 1622941 tttatccgcg actgcaaaat atgaagatat gaagcatatt gtcaaacggt tttcatccgt 1623001 ccctgtcaat cagtatattt ttacgaaaat agatgaaacg acttccttag gttctgtatt 1623061 taatatactg gcagaatcaa aaataggtgt cgggtttatg actaacggcc agaatgtgcc 1623121 tgaggatata cagactgtat ctccacttgg ttttgtgagg atgctgtgca gatgaacaga 1623181 tatgaccaag cagcaacttt acgggcgaaa atggaaaaac gtgagcgcgt tctgccaatg 1623241 gtttattcac aaaaagcgaa gacacttgct gtcatcagcg gcaagggcgg tgtcggaaaa 1623301 tccaatatta ccttaaatat ggcacttgcg ctgcaggata aaggtaagaa ggtgctgctc 1623361 atcgaccttg atatcgggat ggggaacatt gatatattaa taggaaattc atcgtctgcc 1623421 acgataatcg atgttttaac cgatcgtaag cctttgctgc agtcattatc cgttggccca 1623481 aagggtttgc ggtatatatc agggggaacc ggtcttgatg tgatgtttca gctcgatcag 1623541 agaaaatgga cgttttttgc caatgaactt tctcatgcat taagccagtt cgattatgtg 1623601 ctgtttgaca tgggagcagg cttatcaaaa gatcaactgc cttttatttt atcagcagaa 1623661 gatattttga ttattacaac tcccgagccg acggccatta tggacgcata cagcgctgtc 1623721 aagcacttgg ttttgacaga aaataagctt tcaatgaagg tggctgtcaa tcggtgccgt 1623781 gaccaaaagg aagggcttga cgcttttgcc cgcctctccc gtacaattca tatgtttttg 1623841 gatgttcagg ttcagtttgc cggttccgtt tctgacgatg tgatcgtgag caaagcggtt 1623901 gtcgaacagg ttcctttttt cataaaaagc cctcaggcaa aagccagccg gtcagtccgt 1623961 attttagcgg acgccttgtt tgaaagagaa gaaacgagac acaaagaaga caaacagaca 1624021 tttattgaga aattatcttc ttttttaatg aggagggctt aatttgattc gtgtgcttgt 1624081 agttgatgat tcagctttta tgagaaaaat gataagtgat tttctgaccg aagaaaagca 1624141 gatagaagta atcggaactg cgagaaacgg agaagaagcg cttaagaaga ttgaattatt 1624201 aaaaccggat gttattactc ttgatgttga aatgccggtc atgaatggga cagatacgct 1624261 ccgcaaaatt attgagattt ataacttgcc ggtcattatg gtgtctagcc agaccgagaa 1624321 aggtaaagaa tgcacaatta attgtttgga gatcggtgcc tttgacttta tcacaaagcc 1624381 atcaggctca atatctctgg atctatacaa aattaaagaa caactagttg agcgtgtcgt 1624441 cgcggcagga ctttccggca agcggaaacg tcctgtttcc cagacagttc ggcccgaacc 1624501 tattgtgcgt gctgtcgtta agcctgaatt aagcaaaccg aaacctggca cgggcagaca 1624561 aattgtgtgt atcggcacat caacaggcgg tccacgggcg ttacaaaagg tgataccgaa 1624621 gctccctaag gatttgaacg caccagtggt tgtcgttcag cacatgcctg aagggtttac 1624681 tgcttctttg gctgatcggc tgaatcattt atctgacatt caggtaaaag aagcaaaaga 1624741 tggtgaagca gctcttaacg gctgtgttta catagcaccg ggcggaaaaa acatatccgt 1624801 tattaaaaac agcgaaggac tccaggttgt gcttgataac catgacacac caagccgtca 1624861 taaaccatct gctgattatt tattccgttc tgtcgggaaa ctgacagatt atgaaaaagt 1624921 agcggttatc atgaccggaa tgggcagtga cggcactgct ggactaaagg acatgctaac 1624981 agccggcaat gtgaaagcca ttgcggagtc tgaagaatct tgtgtcgtat acgggatgcc 1625041 aaaagctgct gttaaagcgg gtctcattca tgagattaaa catgtggaag atatcgcagc 1625101 atccatcaca agctgtgtga aaaaagagag ggtgtgattc aaatggatat gaatcagtat 1625161 ttagatgtct ttattgatga gagtaaagaa catttacaaa catgtaatga aaagcttctt 1625221 cttttagaga aagacccgac tgatcttcag ctcgtacatg atatattcag ggctgcccat 1625281 acattaaaag gaatgagcgc aacgatgggc tacacggatt tagcacatct tacccatctg 1625341 cttgaaaacg tgctggatgc aatccgaaac ggagacatgg aagtcacctc agactggctg 1625401 gatattttgt ttgaagctct ggatcacctg gaaacaatgg ttcagtctat tattgatggc 1625461 ggggatggta aaagagatat ctcagaagtg agtgccaagc ttgatgtgaa tggtgcgcac 1625521 gctgaatccg ctgcctccgc tgaacctgca gaagcacaga gttcagcatc tgattgggaa 1625581 tatgatgaat ttgaacgcac agttatacaa gaagcggagg agcaaggctt caaacgatat 1625641 gaaatcaaga tttctctgaa cgaaaactgt atgttaaaag cagttcgtgt ctatatggtg 1625701 tttgaaaaac taaatgaagt cggagaagta gccaaaacaa ttccaagtgc tgaagtgctt 1625761 gaaacagaag attttggaac tgactttcaa gtttgtttct taacacatca atcagcggaa 1625821 gacattgaac aattaatcaa tggcgtgtcg gaaattgagc atgttgaagt cattcaaggg 1625881 gctcctttaa catcagctga aaagcctgaa gaatctaagc aagaagattc accagcagca 1625941 gctgtacctg cgaagcagga gaaacaaaaa cagcctgcta aaaacgatga acaggcgaag 1626001 cattcagccg gcggatctaa aacaattcgt gtcaacattg acaggcttga ttctttaatg 1626061 aacttatttg aagagcttgt cattgaccgc gggcgtctcg agcagattgc gaaagagctt 1626121 gagcataatg aactgactga aacggttgaa cgaatgacga gaatttccgg agatttgcaa 1626181 tcgattattc tgaatatgag aatggtcccg gttgaaactg tttttaacag attcccgaga 1626241 atgattcgcc agcttcagaa agagctgaat aaaaaaattg aactctcgat catcggtgcg 1626301 gaaactgaac tggatcgtac agtaattgat gaaatcggag atccactcgt tcacttgatc 1626361 agaaacagta ttgaccatgg tatcgaggcg ccggaaacac gtttgcaaaa gggaaaaccg 1626421 gaatcaggaa aagttgtgct taaagcttat cacagcggca accatgtctt tatcgaagta 1626481 gaggatgacg gcgcaggcct taatcgaaaa aaaattctgg aaaaagcgct tgagcgcggg 1626541 gtcataacgg aaaaagaagc tgaaacctta gaagacaacc aaatttacga attgattttt 1626601 gctccggggt tctcaactgc tgaccaaatt tctgatattt ccggccgcgg tgtaggactt 1626661 gacgttgtaa aaaacaaact ggagtctctt ggcggttcag tcagtgtgaa atcagccgag 1626721 ggtcaaggct ctctattcag catccagctg ccgcttacct tgtctattat ttcagttctg 1626781 ctgattaagt tggaagaaga gacatttgcc attccgattt cttcaatcat tgagacagca 1626841 gttattgaca gaaaagacat tttgcaaacg catgaccgtg aagtgattga ctttagaggg 1626901 catattgtcc ctgtcgttta tttaaaagaa gagtttaaaa tagaagatac aagaaaagat 1626961 gcggaacagc tccatatcat tgtcgtgaaa aaaggcgaca aacctactgc atttgtggtg 1627021 gactccttta ttggccagca ggaagttgtg ctgaaatcac tcggagatta tttaacaaac 1627081 gtctttgcaa tttccggagc tactatttta ggagacggag aagtagcgct cattattgat 1627141 tgtaatgcac tgattattta accattcgag gaggtgtctc acatgactgc agaaattaaa 1627201 acaggcgaaa aaatgatagt ctttatggta aatggcaaag aatatgccat ttccgtcact 1627261 caggtgaaat caattgaaaa atggcaaaag ccaacgaggg tacctggcgt cgaaccatat 1627321 atttgcgggg taatcaattt acgcggggtg gtgactccgg ttattgattt aagaaaacgc 1627381 ctgaatttgc cagagtatga aattacagat gaaacacgaa ttatcattat tgcttatcgt 1627441 gatattgaag tcggctggat tgtggatgaa gcgaatgatg tgattaccgt acacgaaagt 1627501 gaaatagaat ctgctccaga aggcgttcag aaagatacgg atgtgtcgat cgaacagatt 1627561 gtgaaacaag agaacagact cttaaatatt attgatgcga acgcggtttt ggataaagaa 1627621 tcatctcagt ccgctgtgcc cgatcaagct taatcttaaa ggggttatga catgagtatt 1627681 tttaatggaa tcaaagaaga gcagatggac attttgcggg aagtcggcaa tataggcgcc 1627741 ggccactccg cctctgcaat ggcccagctg ttaaatagaa agatagatat ggaagtccca 1627801 tttgcaaagc tgctgtcttt tgatgagctt gttgattttt tcggcggcgc cgatgtcccg 1627861 gttgccagca tctttttaag aatggaaggc gatttaacgg gttcaatgtt ctttataatg 1627921 cctttttttc aggcggagca gtttatcaga gagctgattg gaaaccccga ttttgacata 1627981 gaggacttag gtgaagacca catgagctca tccgctttgc atgaactggg caatatttta 1628041 gcggggtcat atttaacagc tttggcggat ttgacgaaac tccagctcta tccaagtgtt 1628101 cctgaagtct cattggacat gttcggagct gtgatcagcg aagggctgat ggagctcagt 1628161 caggttggag aacacgccat tgttgtcgac acgtcaattt ttgaccaaag ccatcagcag 1628221 gagctgaaag cgcatatgtt tatgctgccg gactatgatt catttgaaaa gctctttgtc 1628281 gccttaggtg catcattatg agtacaactg aggctgttgt tataaaggtt gggattgctg 1628341 acgtgaagat cgcccgcttc ccggatacca tccggacctc tggtttgggc tcatgtgtgg 1628401 ggctggtgct ttatgataaa gaaaagcaaa cggcgggtct tgttcatgtc atgcttccgg 1628461 attcgacgtt atcgaaaact gccgagctca accgggctaa gtacgctgac accgccgtac 1628521 agaccacgat tgatatgctg atagaagcgg gatgccggaa atttgcatta aaagcaaagc 1628581 tggccggcgg atcagagatg tttaaattta aatcgacaaa tgatttgatg aagatcggac 1628641 cgagaaatgt attagcgata aaagaacagc tgtctttatt taatattcct attattagtg 1628701 aagatacggg cggctcaagc ggccggacga tagaatttga accgaagtcc tgcatgctgc 1628761 atattcgaac tgttaaacaa ggtgaaaaaa cgatttaatt aaggtattag ggggataaca 1628821 atgcaatcct tgaattatga agatcaggtg ctttggacgc gctggaaaga gtggaaagat 1628881 cctaaagccg gtgacgactt aatgcgccgt tacatgccgc ttgtcacata tcatgtaggc 1628941 agaatttctg tcggactgcc gaaatcagtg cataaagacg atcttatgag ccttggtatg 1629001 cttggtttat atgatgccct tgaaaaattt gaccccagcc gggacttaaa atttgatacc 1629061 tacgcctcgt ttagaattcg cggcgcaatc atagacgggc ttcgtaaaga agattggctg 1629121 cccagaacct cgcgcgaaaa aacaaaaaag gttgaagcag caattgaaaa gcttgaacag 1629181 cggtatcttc ggaatgtatc gcccgcggaa attgcagagg aactcggaat gacggtacag 1629241 gatgtcgtgt caacaatgaa tgaaggtttt tttgcaaatc tgctgtcaat tgatgaaaag 1629301 ctccatgatc aagatgacgg ggaaaacatt caagtcatga tcagagatga caaaaatgtt 1629361 ccgcctgaag aaaagattat gaaggatgaa ctgattgcac agcttgcgga aaaaattcac 1629421 gaactctctg aaaaagaaca gctggttgtc agtttgttct acaaagagga gttgacactg 1629481 acagaaatcg gacaagtatt aaatctttct acgtcccgca tatctcagat ccattcaaag 1629541 gcattattta aattaaagaa tctgctggaa aaagtgatac aataatgaat ttcatggtta 1629601 gcgagtgaaa aacatgtcaa cactattatg gcttttaagc tttatgctcc acggcgttct 1629661 tctgtacgct gtcattatcc tgtatacgag gctcgctgca gtgaaagaaa cagaaaaaca 1629721 gcaaaaacag atacttgaag agacggaaaa caccttggcg gcatttctgc ttgaattaaa 1629781 agaagaaaat gagaaactga tagaaaataa agcttcatct gcaagtcaat cagatgaaga 1629841 atcccaaaag tcaggccttc agacctctga aacatatcaa gagcgggatc cagtccaaga 1629901 ggcagagaat cttcctgaac atattgaagg tctgattaca gaggttgacc gtcgggaaga 1629961 gctcgtaaac agtgaggtcc aatcatttga agaccaggtc atagaattat atgaacaggg 1630021 atattcggca agtcaaattg cccagaaaat gaagagcgga aagacagaaa tcgagctatt 1630081 tttaaaattt cgctccaaag gtgtaaagga ttcttgattg tcggataaag ctgtgttata 1630141 ttatgtcttg gtgttaaata cacacgctta acgatttatg cagagggtgc tgcaggcggc 1630201 agttctgtac aaaaatgacc taagcggagg aaaaaaacca ttatattagg aggaaataac 1630261 atgtcagtca tttctatgaa gcaattgctt gaagctggtg ttcacttcgg tcaccaaaca 1630321 cgccgttgga acccaaaaat gaagcgttac attttcacgg agcgtaacgg aatctacatc 1630381 attgaccttc aaaaaacagt caaaaaagta gaggaagctt acaacttcac taaaaatctt 1630441 gctgctgaag gcggaaaaat ccttttcgtc ggaacaaaaa aacaagctca agattctgtt 1630501 aaagaagaag ctcaacgctc tggcatgtac tatgtcaacc aacgctggtt gggcggtaca 1630561 ttaacaaact tcgaaacaat ccaaaaacgt attaaacgtc ttaaagacat tgaaaaaatg 1630621 caagaaaacg gtacgtttga tgtacttcct aaaaaagaag tcgttcaatt gaaaaaagaa 1630681 ttagagcgtc ttgaaaaatt cctaggcgga attaaagata tgaaggatct tcctgatgca 1630741 ttattcatca tcgatcctcg caaagagcgc atcgctgttg cggaagctcg caaattaaac 1630801 atccctatca tcggtatcgt agatactaac tgtgatccag atgaaatcga tgttgttatc 1630861 ccagcgaacg atgacgctat ccgcgctgtt aaacttctaa cttctaaaat ggcagatgca 1630921 atcttagaag cgaagcaagg cgaagaagaa gcggaagttg ctgaagaaac tgcaccagaa 1630981 acagaaacaa caactgcgta acctattcaa aaggtgataa gagggactgc cttttatcac 1631041 cttttttcaa gaaaaatgtg taatatacat actcttgttt aaacatataa ggaggaatac 1631101 aaatggcaat tactgcacag caagtaaaag aactgcgtga aaaaactggc gcgggcatga 1631161 tggattgtaa aaaagcgtta actgaaactg acggagatat ggacaaagca attgaccttt 1631221 taagagaaaa aggaattgca aaagcagcga aaaaagctga ccgtatcgca gcagaaggtt 1631281 ctactcttat taaaactgac ggcaacaaag gcgttatcct agaagtaaac tctgaaactg 1631341 atttcgttgc gaaaaacgaa ggttttaaag agcttcttaa cactttagct gaccaccttc 1631401 ttgcaaacac gccagctgat gttgaagaag caatgggcca aaaaatggaa aatggctcaa 1631461 ctgttgaaga gtacatcaca agcgcagttg ctaaaatcgg tgagaaaatc actcttcgcc 1631521 gctttacagt tcttacaaaa gacgacagct ctgcattcgg tgcgtacctt cacatgggcg 1631581 gccgcatcgg tgtattaact gttctcaacg gtacaactga tgaagaaact gcgaaagata 1631641 tcgcaatgca cgttgctgca gttaaccctc gttacatttc tcgtgatcaa gtatctgaag 1631701 aagaaacaaa tcatgagcgt caaatcttaa ctcagcaagc cctccaagaa ggcaaacctg 1631761 aaaacatcgt agcgaaaatg gttgaaggcc gtctgaacaa attcttcgaa gaaatttgtc 1631821 tattagacca agcgttcgtt aaaaacccag atgaaaaagt gaaacaagtt attgcagcga 1631881 aaaacgctac tgttcaaact tttgtccgct atgaagttgg agaaggcatc gaaaaacgtc 1631941 aagaaaactt tgctgaagaa gtaatgaacc aagtgaaaaa ataatggtga aaagatttcg 1632001 cggctaagtc gcgtcttttc aggcagtata ggggacacat tttgtgttcc ctatttttaa 1632061 aactatattt acaaaccttt ttttctcttg cataatagaa aacggcaatg tttacacttg 1632121 gaggttatca tggaaaaacc aaaatacaaa cgtatcgtat taaagcttag cggggaagca 1632181 ttggcaggag aacagggaaa tggaattaac ccgactgtca ttcaatccat tgcaaagcaa 1632241 gtgaaggaaa tcgctgagct tgaagtcgaa gtggctgttg ttgtaggcgg cggcaactta 1632301 tggcgcggaa aaacaggaag tgacctgggc atggaccgcg cgactgctga ctatatggga 1632361 atgctggcga cagtaatgaa ttcgcttgct cttcaagaca gcttggaaac actcggaatc 1632421 cagtccagag tgcaaacatc cattgaaatg agacaagttg ctgaaccgta cataagaaga 1632481 aaagcgatac gccacttaga gaaaaaacgt gtcgttattt tcgctgcggg cacaggaaac 1632541 ccatatttct caactgatac gacagctgca ctgcgggctg ctgaaattga ggcagacgtt 1632601 attttaatgg ctaaaaataa cgttgacggt gtgtataatg ctgatcctag aaaagatgaa 1632661 tcagctgtta agtatgaatc actttcttat cttgacgttc ttaaagacgg cctggaagtc 1632721 atggattcaa cagcttcctc tttatgcatg gacaatgaca ttccgcttat cgtcttttct 1632781 attatggaag aaggaaatat caaacgtgcc gttatcggtg aatcaatcgg aacgatcgtg 1632841 agggggaaat aacgtgtcaa aagaagtatt aactcaaaca aaagaaaaaa tggaaaaagc 1632901 aattgctgct tatcagcgcg aattggctac tgtacgcgca ggccgtgcaa atccatcatt 1632961 attagataaa gtaacggttg aatattacgg agcgcagaca cctttaaatc agttgtcttc 1633021 tattaacgtg cctgaagctc gtatgctcgt tatcacgcca tacgataaaa cagcaatcgg 1633081 tgatatcgaa aaagcgattt taaaagctga tttaggtctt acaccaacaa gtgacggcaa 1633141 tatgattcga attgcaattc cggcactaac agaagagaga cggaaagaat tagtgaaagt 1633201 tgtaaaaaaa tatgctgaag aagcaaaagt agctgttcgt aacgttcgcc gtgatgctaa 1633261 cgatgatctc aaaaaacttg agaaaaacgg agacattact gaggatgaac tgcgtgcttc 1633321 cactgaagac gttcaaaaac tgacagatga atatgtgtca aaaattgaca gtgtcacaaa 1633381 agacaaagaa aaagaaatca tggaagttta atgaaaaact atgtacaata gataatagtg 1633441 aaaagaccct ctcatgttta cagggggttt ttttgttaat actgttgatt acattgatta 1633501 tcagcaggga atgtaacctt tttgggtgac ggaggaatct catgctcaac atactcaaaa 1633561 attggaagaa tcagcaaact gcggcttcca acttagaacg ttatacaaaa gaagacatac 1633621 ttaagggaga aattcccgaa cacatcgcca ttatcatgga tggaaatggc cgttgggcta 1633681 aaaaacgctc tcttcccaga attgcaggcc accatgaagg gatgaaggtg gtaaaaagga 1633741 ccacgaagct cgcaaacgaa ttaggtgtca aagtactgac attgtatgca ttttcaacag 1633801 aaaactggaa aagaccgaaa atggaggtcg attttttaat gaagcttccg gaagaatttt 1633861 tgaatacgta tcttccagag cttgttgagg aaaatgtaca ggttcggatc attggggatg 1633921 aaacggcttt gccggcgcac acattacgtg cgattgaaaa agctgtacag gacacggcgc 1633981 aaaacgacgg aatgatcctt aattttgctc ttaactatgg aggccgtact gaaattgtca 1634041 gtgctgcaaa atcactcgcg gaaaaagtga aggaaggctc tttgaatatt gaagacattg 1634101 atgaatcgct tttttctact tatttgatga ctgaatcttt gcaggatcct gaacttttaa 1634161 ttcgaacgag cggcgagata aggctgagta attttatgct atggcaggtt gcctacagtg 1634221 aatttgtctt tactgacgtc ttgtggcctg actttaaaga agatcacttc ttgcaggcgt 1634281 taggagagtt tcagcagaga ggccggaggt ttggcggaat ttagaggatg gtggacatga 1634341 aacaaagaat tttgacaggt gttctggcag caattgtatt tttatttttg gttattgtcg 1634401 ggaaattgcc gttcaccata ttaatttatg ctatgggcag tgtggcgctt tttgaacttt 1634461 tacggatgaa aaagctgaag ctggtttcac tgccgggttt gatcggtctt ttattattgt 1634521 ggatgttctt attaccaagc cagtattcgt tttttgaagc ggacgggatt tccaaaatgg 1634581 aaatcgcttt atttgcggta ctgctattgc tgacttacac agtgttggtc aagaacacct 1634641 ttacttttga tgaagtcggg tttattacgc ttgcagcaat ttacatcgga atgtgttttc 1634701 attattttat cgaaatcaga aatcttgacc aatacggatt aacatacatt ttttatgcgt 1634761 gtgttgtcat ttggtccacc gattccggtg cctattttgt cggtaaatcg cttgggaagc 1634821 ggaaactgtg gcctgaaatc agtccgaata aaacagtgga agggtttgca ggcggaattg 1634881 tcatcgcact tgtattggcg acgatttttc agcttgttgc acaacttccg atcccgtata 1634941 tctatctgct gttgatcacg ctgtttttgt ctgtttttgg acaactggga gatttagtgg 1635001 aatccgcctt gaaaagacat tacgatgtaa aggattctgg gaatattctt cccgggcatg 1635061 gcggtatatt agaccgtttt gacagtttct tgtttgtcat gcctttcttg tactttctgc 1635121 ttgccctttt ttcataaaaa agtctaatat gaatatgaga ctgatcatgc agcaataaga 1635181 ataggagtag tggcaacttt gaaaaatatt tgtcttttag gagcaacagg atcaatcggc 1635241 gaacagactc ttgatgtact gcgtgcacat caagaccaat ttcagctggt atctatgtcg 1635301 tttggcagaa atattgataa ggccgttcca atgattgagg tctttcagcc gaagtttgtc 1635361 tctgtcggtg atctggatac atatcataaa ttaaaacaaa tgtctttttc ttttgaatgc 1635421 caaatcgggc tgggagaaga aggactgata gaagcagcag tgatggagga ggttgacatt 1635481 gttgtcaacg ctttgcttgg aagcgtcggt cttatcccga cattaaaggc aattgaacag 1635541 aaaaaaacaa ttgcgcttgc aaataaggaa actcttgtca ctgcagggca tatagtaaaa 1635601 gaacatgcta agaaatatga tgttccgctg ctgcctgttg acagtgagca ttcagccatt 1635661 tttcaagctc ttcaaggcga acaggctaaa aacattgaac gcctcatcat tacggcatcc 1635721 ggcggaagtt ttcgggacaa gacgcgggag gagctcgaat cagtaacggt tgaagatgca 1635781 ttaaaacatc caaactggtc aatgggtgca aaaattacaa ttgattcggc tacaatgatg 1635841 aataagggat tagaggtgat cgaggcacac tggcttttcg atatacctta tgaacaaatt 1635901 gatgtggttt tacataagga gagcatcatc cattcaatgg ttgagttcca tgataaaagt 1635961 gtgatcgcac agctcggaac tccggatatg agagtcccca ttcaatatgc gctcacttat 1636021 cctgaccgat tgccattacc agatgcgaaa aggcttgaat tatgggaaat cggcagcctt 1636081 cattttgaga aagctgattt tgacaggttc cgatgcttac aatttgcttt tgaatcaggt 1636141 aaaataggag gaacaatgcc gacagtgcta aatgcggcaa acgaagtagc tgtcgctgcc 1636201 tttttagctg gcaagatacc gtttttggct attgaagact gtatcgaaaa ggcactaacc 1636261 cgccatcaat tactgaaaaa accgagcctg gcggacattc aagaagtgga caaagatacc 1636321 cggggatacg tcaattcaat actcacataa ggtggtatgt tcgtgaatac agttatagcg 1636381 tttatcatta ttttcggaac gctcgttttc ttccatgaac tgggccattt attgctagcc 1636441 caaagagcgg gaattctctg ccgtgaattt gcgatcggct tcggtccaaa gattttttct 1636501 ttcaaaaaaa atgaaacagt ttatacgatc aggctgcttc cggtcggcgg atttgttcgt 1636561 atggccggcg aagatccgga aatgattgag gtgaaacccg gatacacggt cgggcttctg 1636621 tttaataagg aagatcaagt tgagaaagtc atcatcaatc aaaaggaaaa atatccggat 1636681 gctttagtca ttgaagtgga aacagcggat ctagagcatg acatgaagat caccggttat 1636741 gaacagggga aagaggacga actttccagc tttactgtca gcgaaacatc cttttttatt 1636801 gtagacggag aagaagtgca gattgcgccg tataatcgcc aatttggttc caaacctgta 1636861 tggcagcgga ttaaagcaat tgctgcaggg ccgattatga actttatttt agcttacgtc 1636921 attttagtga tgcttgggct gattcaaggc gtaccgtcaa atgaacctat gctcgggcag 1636981 ctgacagaca atggacgggc ggctgaagca gggctaaaag aaggggatta tatccaaagc 1637041 attaacggag agaaaatgag gtcttggact gacattgtct ccgctgtaaa agaaaacccg 1637101 gagaaagaaa tggacgttgc agtaaaaaga gataacaaaa cgcttcatat ttcggtgact 1637161 ccggaagctg ttaaagatga gaacaaaaaa acaatcggac gtttcggttc ctatgcgccg 1637221 actgaaaaag gcgtactctc agcggttgct tacggcgcga catcaacagt tgatgtcacc 1637281 aaagccattt taaccaatct gagcaaatta gtaacaggcc aatttaaact cgatatgctg 1637341 tcaggtcctg tcggcatata tgacatgaca gaccaagtgg cgaaaacagg gatcgtgaac 1637401 ttatttcagt ttgcggcgtt tttaagcatt aaccttggga ttgtcaacct gcttccgatt 1637461 ccggcacttg acggaggaag actgttgttt ctatttattg aagcgattcg gggcaaaccg 1637521 attaacaggg aaaaagaagc atttgttgtg tttatcggag tagctttctt aatgcttctt 1637581 atgctggttg tcacatggaa cgatatccag cggctgtttt tgtaaacgaa aagtaaatca 1637641 atcagaggtg cgaagaaatg agacaaagct tgacgcttat tcctacgctc cgtgaagttc 1637701 cagctgatgc cgaagcaaaa agtcatcagc ttcttctgag agcaggattt atcagacaga 1637761 atacgagcgg ggtatacagc tatatgcctc ttgcgtataa ggtgattcaa aacattcagc 1637821 agattgttcg agaggaaatg gagaaaattg atgccgtaga aatgctcatg cccgcattgc 1637881 agcaggcaga gacatggcag gaatcaggca gatggtatac gtatggtccc gaactgatga 1637941 gactaaaaga ccgtcatggc cgtgaatttg ctttaggggc aacgcatgaa gaggttatca 1638001 cttcgcttgt tcgcgatgag gttaaatctt ataagcgtct ccctctgact ctttatcaaa 1638061 ttcagtctaa gttcagagat gaaaaacgtc ctcgcttcgg tttgttaaga ggccgcgaat 1638121 ttattatgaa ggatgcgtac tctttccatg catctgcaga gagcctggat gaaacgtatc 1638181 aaaaaatgta cgaggcctat tctaatattt ttgcccgctg cggcattaat gtaagacctg 1638241 ttatcgctga ttcaggcgca atgggaggaa aggatacgca cgaatttatg gcactttctg 1638301 cgatcggaga ggatacgatt gcgtattctg atgaatcaca gtacgcggct aatatcgaga 1638361 tggctgaagt tcttcaccag gaagttcctt cagatgaaga gcctaaagct ctagagaagg 1638421 ttcatacgcc taacgtgaaa acaatcgaag aactgactgc gttcttacag gtttcggctg 1638481 aagcgtgcat taagtcagta ttgtttaaag ctgatgaccg ttttgtctta gtgcttgtaa 1638541 gaggggatca tgaagttaac gatattaaag tgaaaaactt gcttcatgca gaagttgtag 1638601 agcttgctac acatgaagag gtcattcagc agctcggaac agagccaggc tttgtaggcc 1638661 ctgtcggtat tcatcaggat gtggaagtat atgccgatca agctgtgaaa gcaatggtta 1638721 atgctgttgc cggggcaaat gaaggagatc atcattataa aaatgtcaat gtgaatcgtg 1638781 acgcgcaaat taaagaattt gctgatcttc gttttattaa agaaggtgat ccttcaccag 1638841 acggcaaggg aacgatccgt tttgctgagg gaatcgaagt cggacaagtc tttaagctcg 1638901 gaacacgcta ttcagaagcg atgaatgcga catatttaga tgaaaacgga cgcgcgcagc 1638961 caatgctgat gggctgttac ggaatcggtg tgtcaagaac gctttctgct attgctgaac 1639021 agcatcacga cgaaaaaggc ttaatatggc caaaaagcgt tgcgccgtac gatcttcata 1639081 ttcttgcttt gaacatgaaa aacgatgggc aaagagagct tgctgaaaag ctgtatgccg 1639141 atttaaaagc ggaaggctat gaagtgctct atgatgaccg tgctgagcgt gccggcgtaa 1639201 aattcgctga ttcagattta atcggccttc caatccgcat cactgtcgga aaacgagctg 1639261 acgaaggaat cgtcgaagtg aaaattcgtc aaactggtga gtcaactgag atttcagtag 1639321 acgaattatc tgcgtttatc agcaagcagt aatcaccata acgatttatc aaaaaacatg 1639381 ttaaaataga aataatagaa ggtacctcat tgcctgaggt accttcactt atgatgtttt 1639441 tagggaggga tactgtctta atggaacagt tatcagtaaa cagaaggcag tttcaaattc 1639501 ttctgcagca gattaatatg acagatgata ccttcatgac atactttgaa catggcgaga 1639561 ttaaaaagct gacaattcac aaagcttcta agtcttggca ttttcatttt caatttaaat 1639621 ctttgctgcc ttttcaaata tatgacacat taacaacgag gctgacgcaa tcgtttgccc 1639681 acatagcaaa agtgacatct tcaattgaag ttcaggatgc cgaggtcagt gaaagtatcg 1639741 ttcaagacta ctggtcacgc tgcattgaag aactgcaggg catttcgccg ccgattatca 1639801 gtcttttaaa ccagcaaaaa ccgaagctga agggcaataa actgattgtc aaaaccaaaa 1639861 cagatacaga agcggctgcg ctaaagaaca aatacagttc catgattcaa gcagaatacc 1639921 gtcaatttgg ctttccggat cttcagcttg atgctgaaat atttgtatcc gagcaagaag 1639981 ttcaaaagtt tcgggagcaa aagcttgcgg aagaccaaga gcgggctatg caggccttga 1640041 ttgaaatgga gaagaaagat aaagaaagtg atgaagacca agcaccatct ggtcctcttg 1640101 ttatcggtta tcaaattaaa gataacgagg aaatccgaac acttgacagc atcatggacg 1640161 aagaacggag aattacggtc caaggttatg tgtttgatgt ggagacgcgc gagctgaaga 1640221 gcgggcgcac gctgtgtatc ttcaaaatta cagactatac aaatagtatt ttgatcaaaa 1640281 tgtttgcacg tgaaaaagaa gatgcggcgc tgatgaagtc tctgaaaaaa ggaatgtggg 1640341 taaaagcacg cggaagcatt caaaatgata catttgtcag agaccttgtc atgatcgcaa 1640401 atgacgtaaa cgaaataaaa gcaaaaaccc gtgaagattc agcacctgaa ggagaaaaaa 1640461 gagtggaatt gcatcttcat tccccaatga gccaaatgga tgctgttacg ggtatcggaa 1640521 agcttgtcga acaggcgaaa aaatgggggc atgaggccat cgctttgacc gaccatgctg 1640581 tcgttcaatc cttccctgat gcgtattctg cggccaaaaa gcatggaatt aaaatgattt 1640641 acgggatgga agcgaatctc gtggatgatg gcgtgccaat tgcttataat gccgcacatc 1640701 gtctgctcga agaagaaaca tatgttgttt ttgacgttga gacgacagga ttgtctgctg 1640761 tatacgatac cattattgag ctggctgcag taaaagtaaa aggcggagaa attattgata 1640821 aatttgaggc gtttgcgaac ccgcatcgtc cgctttccgc cacaatcata gagctgacag 1640881 ggatcacaga tgatatgcta caagacgctc cggatgtcgt agatgtaata agagatttca 1640941 gagaatggat tggcgatgat attcttgtcg ctcataatgc aagctttgat atgggattct 1641001 taaatgtagc ctataaaaaa cttcttgaag tcgaaaaagc taaaaaccca gtcattgata 1641061 cgcttgaact tggacgtttt ctctatccgg aatttaagaa ccaccggttg aacacacttt 1641121 gtaaaaagtt tgatatcgag ctcacacagc atcaccgtgc gatctatgat actgaggcaa 1641181 ccgcttattt gcttctgaaa atgctgaaag acgcagctga aaaaggtatt cagtaccatg 1641241 atgagttgaa tgaaaatatg ggtcagtcca atgcttatca aagatcaaga ccgtatcatg 1641301 caacattact tgccgtgaac agcacgggac ttaaaaattt atttaagctt gtgtcacttt 1641361 ctcatattca ttatttttac agagtgccgc gtattccgag atctcagctt gagaaataca 1641421 gggaagggct tctgatcggt tctgcttgtg acaggggaga ggtttttgag ggaatgatgc 1641481 aaaaatcgcc tgaagaggtg gaagatatcg cgtcattcta tgattacctt gaggttcagc 1641541 cgcctgaagt gtatcgtcac ttgctggagc ttgaactggt ccgtgatgaa aaagcgctga 1641601 aagaaattat tgcgaatatc acgaagctgg gggaaaagct taataaaccg gttgttgcta 1641661 cgggaaatgt tcattacttg aatgatgagg ataaaatcta cagaaagatt ttaatatcct 1641721 cacaaggcgg ggcaaatccg ctgaataggc atgaactgcc gaaagtgcat ttcagaacga 1641781 cagacgaaat gcttgaagct ttttctttct taggtgaaga aaaagcgaag gagatcgtag 1641841 tcaccaatac ccaaaaggtt gcttctttag ttgatgacat caagccgatt aaagatgatt 1641901 tatatacgcc gaaaatcgaa ggcgctgatg aagagatcag agaaatgagc tatcagcgtg 1641961 caagaagcat ttacggggaa gagctgcctg aaattgtcga agcgcggatt gaaaaagagt 1642021 taaagagtat tattggccac ggatttgctg ttatttactt gatctctcac aaacttgtaa 1642081 aacgttcact agatgacggg tatctcgttg gttcccgtgg ttccgtagga tcttcattag 1642141 ttgcgacact tactgagatt actgaggtaa acccgctgcc gccgcactat gtttgtcctg 1642201 agtgccagca ttctgagttc tttaatgacg gttctgtcgg ttctggtttt gacctgcctg 1642261 acaagacatg ccctcattgc ggaacgcctt tgaaaaaaga cggccatgat attccatttg 1642321 aaacgttctt aggatttaaa ggggacaaag tacctgatat cgatttgaac ttctcagggg 1642381 aatatcagcc gcaagcacac aattacacaa aagtattgtt cggagaagac aatgtatatc 1642441 gtgcgggaac aataggcacg gtggcagaaa aaacagccta cggttatgta aaaggctatg 1642501 ccggagacaa caatcttcat atgcgcggtg ccgaaataga tcggctcgta cagggatgca 1642561 caggtgtaaa acgtacaact ggacagcacc ctggcggtat tatcgtagtt ccggattata 1642621 tggatattta tgatttttca ccgatccagt tcccggcaga tgccacaggt tcagagtgga 1642681 aaacgactca ttttgatttc cactccatcc atgacaacct gttaaaactt gatattctcg 1642741 gacacgatga cccgactgtt attcggatgc ttcaagactt aagcggaata gatccgaaaa 1642801 caattccgac ggatgatcct gaagtgatga agatcttcca gggaaccgaa tcactcggtg 1642861 tgactgaaga acagattggc tgtaaaacgg gcactcttgg aattcctgaa ttcggaaccc 1642921 gatttgtccg gcagatgctt gaagatacaa agccgaccac tttttctgag ctcgttcaga 1642981 tttcaggctt gtctcacgga actgatgtat ggcttggcaa tgcacaggag ctcatccaca 1643041 ataatatttg tgagctgagt gaggttatcg gctgccgtga tgacattatg gtttatttaa 1643101 tctatcaagg ccttgagccg tcccttgcct ttaaaatcat ggaattcgtg cgtaaaggaa 1643161 aaggattaac gcctgaatgg gaagaagaaa tgaaaaataa caatgtccca gactggtata 1643221 ttgattcctg taaaaagatt aaatacatgt tcccgaaagc ccacgccgcg gcatatgtct 1643281 taatggcagt ccgcattgct tactttaaag tgcatcatgc tcttttgtat tatgcggctt 1643341 attttaccgt tcgtgcagat gactttgata ttgatacaat gatcaagggc tctacagcaa 1643401 tcagagcggt aatggaggat ataaacgcta aaggacttga tgcttcaccg aaggaaaaga 1643461 accttctgac tgttttagaa ttagcgcttg agatgtgtga gagaggctat tcattccaaa 1643521 aagtcgattt atatcgctcc agcgccacag agtttattat tgacggcaac agtcttattc 1643581 cgccgtttaa ctctattcca gggttaggga cgaacgctgc tttgaacatt gtaaaagctc 1643641 gcgaagaagg cgaattcctc tcaaaagaag atttgcaaaa gagagggaaa gtatcaaaaa 1643701 cgattttaga gtacttagat cgccatggct gtctggagtc actgcctgat caaaaccaat 1643761 tgtcactgtt ctaatatgga aagcagaatt tctcagaaat tctgcttcta tgcatacata 1643821 agcgcaaaaa gtgccatcgt aatattagag tttctgtcac ttgcttaggt atgaaggtaa 1643881 gcgtatatcc atttgcaata aaaatatggt tatggtatag ttttattgga aatgctaacg 1643941 attaccgagg caaagagtgg ggaaacccgc tcttttgtat tgaacaggag aattttgtct 1644001 cgacatgttc atcgtttact ttttagcccc tgctcttttg aagcagggtt tttatgcaga 1644061 gtgacgagac gaatatgaga tcgacagcac aaggaggaag aacatgagca aaaaagtgac 1644121 tgacaccgtt caagaaatgg ctcagccaat cgtagacagc cttcagctgg aactcgttga 1644181 cattgaattt gtcaaagagg gccaaagctg gttccttcgc gtgtttattg attccgatga 1644241 cggtgtggat attgaggaat gtgccaaagt aagcgaagct ttaagcgaaa agcttgatga 1644301 ggcagaccca atcagccaaa attactttct tgaagtctca tctccaggag ctgagcgtcc 1644361 gctaaagaaa aaagccgatt tcgaaaaatc actaggaaaa aacgtataca ttaagacgta 1644421 tgagcctatt gacggcgtaa aagtgtttga aggtgaactg gctgaatttg atggacaaac 1644481 agtgacagtt gagatcacga tcaaaacaag aaagaaacgg atcaatattc cgtatgaaaa 1644541 gatagctaat gcaagattag ctgttacatt ctaatgaata caaatgtttt aaggggggag 1644601 accgttaaat gagcagtgaa ttattagatg ctctcacgat tcttgaaaaa gaaaaaggca 1644661 tcagtaaaga aattatcatc gaagcaatcg aagctgcgtt aatttctgct tataagcgga 1644721 attttaatca agcgcaaaat gtacgggtgg atctaaaccg tgaaactggc tccatccgtg 1644781 tatttgcaag aaaagatgtc gttgacgaag tatacgacca gagattagaa atctcaattg 1644841 aagaggcaca gggcatccat ccggaatata tggtcggcga tgtcgtcgaa atcgaagtta 1644901 cacctaagga tttcgggcgc atagctgctc aaacagcgaa gcaggtcgtc acacagcgtg 1644961 tgcgcgaagc tgagcgcggt gtgatttatt ctgaatttat cgaccgtgaa gaagacatca 1645021 tgacagggat cgtccagcgt ctggacaata aatttatcta cgtgtcttta ggcaaaatag 1645081 aagccttgct gccggttaat gagcaaatgc cgaatgaaag ctacaagccc catgaccgca 1645141 ttaaggtata tatcacaaaa gtagaaaaaa caacgaaggg tccgcagatt tatgtgtcaa 1645201 gaacacatcc aggcctgtta aagcgtttgt ttgaaattga agtgcctgaa atttatgatg 1645261 gaactgtcga gctaaaatct gttgccagag aagccggcga ccgttcgaaa atttctgttc 1645321 gcacagatga tcctgacgtt gatcctgtcg gttcatgcgt agggcctaaa ggccagcgtg 1645381 tgcaagcaat cgtcaatgaa ttaaaaggtg aaaaaattga cattgtcaac tggtccagtg 1645441 atcctgtaga atttgtcgcg aatgcgctca gcccttccaa agtgcttgat gtcattgtta 1645501 atgaagaaga aaaagcgaca actgttattg ttcctgatta ccagctgtct ctggcaattg 1645561 gaaaaagagg acaaaacgca cgcttagctg ctaaactgac aggctggaag attgatatta 1645621 agagcgaaac ggacgcaaga gaacttggaa tctatccgag agaacttgaa gaagatgatg 1645681 agccgctctt tacggagcct gaaactgctg aatcggatga ataagaggtg actttaggtg 1645741 aataaacaca aaaagatccc attacgcaaa tgtgtagtga ctggtgaaat gaagcctaaa 1645801 aaggaactga tccgagttgt acggtcgaaa gaaggcgaaa tctcagtaga cccgaccgga 1645861 aaaaagaatg ggcggggtgc ttatttaacg ctggataaag agtgcatctt agcagcaaaa 1645921 aagaaaaaca ctttgcaaaa tcaatttcaa tcacaaatcg atgaccagat tttcgatgaa 1645981 ttgctggaac tggcggaaaa ggtgaaaaaa taaaatgtct ggaatggaat ggtttccctt 1646041 gctgggtctg gccaatcgag ctcgtaaggt cgtgtcaggc gaagacttgg taataaaaga 1646101 aatcaggaat gcgcgtgcaa agcttgtcct gcttacagag gatgcatcat ctaacacagc 1646161 aaaaaaagta actgacaagt gcaattatta taaagtccct tataaaaaag tcgagagtcg 1646221 cgcggttctt ggacgctcta tcggtaaaga agcccgtgtc gttgtcgccg tcactgacca 1646281 aggttttgcg aataagctga tcagcttgct cgattaatat ttttgggggt gaacgaatgg 1646341 ctaaaatgag agtatacgaa tatgcaaaag cgttaaatgt ttcaagtaag gaaattttga 1646401 ccgcactgaa gaacatggat ttagaagtga ataatcacat ggccatgctt gaagaaaagg 1646461 ccattaaaaa gctagatgcc aaatataaaa aaggcggcgc agctgctaaa tctcaaaagc 1646521 cagcagaaac gaacaaaaac aaacagccac aaggggttaa tcagcaatca gctggaaatc 1646581 aaccaaataa aattcgagac ggaaagaaga atgacgtgca gaataatcaa tttaacaaaa 1646641 acaagaagaa taacaacaac aaaaaaaata aacgcaacaa caacaataat aaaaaccaac 1646701 atcagcaaaa gcctgtaaag ccgaaaaaag agcttcctga gaaaattaca ttctctggca 1646761 ctttaacagt tggcgcactt gctgaagagc ttggcaaaga gccttcagaa ctcattaaaa 1646821 agctgatgct tcttggcgta atggcaacca ttaaccaaga gcttgataaa gacacaatcg 1646881 aactcattgc atcagaatat ggtgttgaaa cagaagaggt cattgtgctt gaagaaacag 1646941 agctggaaaa atacgaagag cctgataatg aagaggatct tgaaattcgt cctcctgtcg 1647001 tgacaatcat gggccacgtt gaccatggga aaacaacgct tcttgacagc atccgtaaaa 1647061 caaaggttgt tgaaggggaa gcaggcggaa tcactcagca tatcggcgct tatcaaattg 1647121 aagagaacgg caagaaaatc acgttcttgg atacaccggg ccacgccgca tttacaacaa 1647181 tgcgcgcacg cggtgcagaa gtaactgata ttacgattct tgtcgtagct gccgatgacg 1647241 gtgtcatgcc gcaaacagtt gaagcgatta accatgcaaa agcagcagag gttccaatca 1647301 tcgttgctgt gaataaaata gataaagaat ccgcaaaccc tgaccgtgta atgcaagaac 1647361 tgacggaata cggacttgtc cctgaagctt ggggcggaga aaccattttt gtgccgcttt 1647421 ccgctttaac tggaaaaggc attgatgagc tcgttgaaat gattttgctt gtcagtgagg 1647481 tagaggaact gaaagcgaat ccgaatcgtc aggcaaaagg aacggttatt gaagctgaac 1647541 tcgataaagg cagagggtca gtcgcgacgt tgctcgtaca gactggaaca ctgcatgtcg 1647601 gtgatccgat cgtagtcggc aatacatttg gccgtgtccg tgcaatggtc aacgacattg 1647661 gccgccgtgt gaaaactgcc ggcccgtcaa ctccggttga aattaccggt ttgaatgatg 1647721 tccctcaagc gggagaccaa ttccttgtct ttaaggatga aaaaacagct cgttctgtcg 1647781 gtgaagcccg tgcttcgaaa cagcttgaag agcagcgcag cgataaagcg aagctcagtc 1647841 ttgatgattt atttgagcaa attaagcaag gtgatgtaaa agacatcaac ctcatcgtaa 1647901 aagctgacgt tcaaggatct gctgaagctt taacggctgc acttcaaaaa attgaagtag 1647961 aaggcgttaa agtgaaaatc atccatacag gcgttggtgc gattactgaa tcagacatta 1648021 tcttggcatc tgcttccaat gcaattgtta tcgggtttaa tgtgagaccg gacggaaatg 1648081 ctaagagtac ggctgaagct gaaaatgtag atattcgact tcaccgtatc atttacaaag 1648141 taatcgacga gattgaagct gccatgaaag gtatgcttga tcctgaatat gaagaaaaag 1648201 taattggtca agtagaagta cgccaaacat tcaaagtatc taaaatcggt acaattgccg 1648261 gcggatatgt tactgaagga accattacgc gcgacagcgg cctccgttta attcgtgacg 1648321 gcgtcgtcat ctttgaaggc gaagtagatg ttctgaaacg ctttaaagac gatgtgaaag 1648381 aagtttcaca aggctatgaa tgtggtatta caattaagaa atacaatgac attcgtgaag 1648441 gtgacatcct tgaagcgttt gtcatgcaag aaattgaaag aacgtgatcg gatttgcgga 1648501 gtgtgaatgc atcatttatg atgcaggatc gctaaaagaa aagcgtgccg ttctgaagcg 1648561 gattttaacc agggttcaaa acaagttcaa tgtttcgatt tcggagattg gctatcagga 1648621 cacctggcaa agaaccagct tcggaatcgc cgctgtttct tcctctcgcg ttcaaacaga 1648681 aaaagaactg cagcgcgtcc tagcgtttat cgattctttt cctgaaattg aacggacgat 1648741 cactaggaca gagtggtttt aacttagagg tgattgaatt gagtatgaga gcaaaccgtg 1648801 tcggcgagca aatgaaaaaa gaactcggtg atattatcag ccgcaagctg aaagacccga 1648861 gaattggttt tctgacagta acggatgtac gtgtatcagg tgatttgcaa attgcaaagg 1648921 tgtatatctc ggttctcggt gacgagaaaa aacgggaaga agcgctgaaa gggctggcaa 1648981 aagcgaaagg atttatccga tccgaaatcg gcagccgcat cagacttcga aaaacgcctg 1649041 aaattgaatt tgagttcgat gaatcaatcg attacgggaa tcggatcgaa acactgattc 1649101 acgaattaca ttcagagaaa ccatctgaat aaaaaaagag aggataggcg tatatcgtct 1649161 gtcctctttc ttcgtttata agaaaaaaac tcaaaagaag gagtgaaagg caaatggtta 1649221 acggagttct ccttttacat aaacctgttg gcatgacatc gcacgactgt gtcatgaaga 1649281 tccgaaagct gttaaaaaca aaaaaagtag gacatacagg aacgctcgat ccggaagtat 1649341 caggcgtgct tccgatttgt gtaggaagag cgacaaaaat agtcgaatac ttaactgaaa 1649401 aatctaaaac gtatgatgca gaaataacat tgggcttttc aaccacaaca gaggatcaaa 1649461 ccggagaaac ggtggaaaca aagcctgtca atcacgacat tgataaagcg gatgtagaaa 1649521 aggttttaaa cagtttaaag gggaaacaag aacaaattcc gcccatgtat tccgctgtaa 1649581 aagtaaacgg caaaaaatta tacgaatacg caagagcagg gattgaagta gaacgtccga 1649641 aacgtatgat aaccattgaa gacattgccc tgacaacaga gattaaacat catggagaaa 1649701 ccgcaagctt ccggtttaca gtgacttgct ccaaagggac ctatgtaagg acgctggcgg 1649761 tcatgatcgg agaaaagctc ggatatccgg cccatatgtc tcatttaatc cgtacggcat 1649821 ccggagattt ttctctcgac gaatgcttta cttttgatga actcgaagca caggcccaat 1649881 ccggaaccgt ggaagagcat acagttccta ttgaacgtgc gctcaatcat ttgccgaaat 1649941 ggatcataag tgatacatta gctaagaaag tagaaaatgg ggctttgctt gagacgcccg 1650001 agcagttttc tgaaatgaca agtggagacc gtattgccgt ctttactgaa tccggaacct 1650061 gcttggcgat ctatttccct catcctgcaa aaaaagggct gttaaagccg gcaaaagtat 1650121 tgatgcaaaa aagcgaacaa tagaaaaaag gtgaccgttc tgtgaagacg atacatatta 1650181 cacatcctca tcatttaata aaagaggagc aggcaaaatc agtgatggcg ttaggttatt 1650241 ttgacggcgt tcatctcggg catcaaaagg taatcggcac agcgaagcaa atagccgaag 1650301 aaaaaggtct gacattagct gtgatgacct ttcatcccca tccttctcac gtgttgggca 1650361 gagataagga accaaaggat ctgattacgc ctcttgaaga caaaataaac caaattgaac 1650421 aattaggcac agaagttctg tatgtcgtta aatttaatga agtgtttgct tctctttctc 1650481 ctaagcagtt tatagaccag tatattatcg gccttaatgt gcagcacgca gtggcaggct 1650541 ttgactttac gtacggcaaa tacggcaagg gaacaatgaa gaccatgccg gatgatttag 1650601 acggaaaagc tgggtgcaca atggtagaaa aattaacgga gcaggataaa aaaatcagtt 1650661 cttcgtatat ccgtaccgcg cttcaaaacg gagatgttga attggcgaat gtcttgcttg 1650721 gacaacctta ttttattaaa ggaattgtca ttcatggtga taaaagaggg cggaccatcg 1650781 ggtttccgac agcgaatgtc ggtttaaata acagctatat cgttccgccc acaggtgtat 1650841 atgccgtaaa agcggaagtg aacggcgaag tttacaatgg cgtttgcaat attggctata 1650901 agccaacgtt ttatgaaaag cgccctgaac agccttccat cgaggtcaat ctgtttgatt 1650961 tcaatcaaga ggtatatgga gccgctataa aaatcgaatg gtacaaacgg attcggagcg 1651021 agcggaaatt caatggcatc aaagaattaa ctgagcaaat tgagaaagat aagcaggaag 1651081 ccatccgtta tttcagcaat ttgcggaaat aacttgcaac gcacgcaaat tttattctaa 1651141 aatatttgca tataggcacg atttttagta tgatagtttt cgtagtctta aaaccattgc 1651201 ttggcaatcc gaagtcaccg acggttgcta ggtaactggg gctaaatatg atttggaggt 1651261 gaaacaggat ggcaattact caagagcgta aaaaccaact catcaatgag ttcaaaacac 1651321 acgaatctga tactggatct ccagaagttc agatcgctat cctaactgac tcaattaaca 1651381 acttgaacga gcatttacgt actcacaaga aagaccacca ctcacgtcgc ggtcttctta 1651441 aaatggtagg taagcgtcgt aatcttctta cgtatctgcg taataaagac gtaactcgtt 1651501 accgtgagtt aattaacaaa ctaggcttac gtcgataatc gtaaaaagcg ggaggattcc 1651561 cgctttttta tcgtattaaa gcgaaatttc ttataacaaa tcattgaaat ccttttacat 1651621 actactttga cattgatatg ttcaattcat ttcgttcata ataggagtaa ttgattattt 1651681 cacacaacga agagaggagt tcgtaattgt atgggacaag aaaaacatgt ctttaccata 1651741 gattgggccg gaagaacgct taccgttgaa accggccagc ttgccaaaca ggcaaatggt 1651801 gctgtgatga tccgctacgg tgatacagca gtacttagta cagcaaccgc ttcaaaagaa 1651861 cctaaaccgc ttgatttctt ccctcttact gtaaactatg aagaaagatt atatgcggta 1651921 gggaaaattc cgggcggatt tattaaaaga gaaggacgtc caagtgaaaa agcggttctt 1651981 gccagccgtt taattgaccg tccgatccgt cctttgtttg ccgatggatt ccgtaatgaa 1652041 gttcaagtca tcagcattgt catgagtgtt gaccaaaact gctcttcaga aatggctgcc 1652101 atgttcggtt catctcttgc actttctgta tcggatattc cgtttgaagg accgattgca 1652161 ggggttactg tcggacgcat tgatgatcaa tttatcatta acccgacagt cgatcagctt 1652221 gaaaaaagcg atatcaatct tgtcgttgcc ggcacgaaag atgcgattaa catggtagaa 1652281 gcgggagcgg acgaagttcc tgaggaaatc atgcttgagg ccattatgtt cggccatgaa 1652341 gagattaaac gcctgattgc attccaagaa gaaattgttg cagcagtcgg caaagagaaa 1652401 tctgaaatta agctctttga aattgatgaa gagcttaatg aaaaagtaaa agctttggca 1652461 gaagaggatc tgctgaaagc catccaagtt catgaaaagc atgcccgtga agatgccatt 1652521 aacgaagtga agaacgcagt tgtggcaaaa ttcgaggatg aagaacatga tgaagacaca 1652581 atcaagcaag tgaagcagat tttatccaag cttgtgaaaa atgaagttcg ccgcctgatt 1652641 actgaagaga aagtaagacc ggacggccgc ggtgtcgatc aaatccgtcc gctctcttca 1652701 gaggttggcc tcttgccaag aacgcacggt tcaggtctat ttacaagggg acaaactcag 1652761 gccctcagcg tatgtacgct aggtgctctg ggagatgtgc aaatccttga cggcttaggt 1652821 gtcgaagagt cgaaacggtt tatgcatcat tacaacttcc cgcaattcag cgttggggaa 1652881 acaggaccga tgcgcggacc gggacgtcgt gaaatcggac acggagcact gggtgagcgt 1652941 gcgcttgagc cagttattcc gtctgaaaaa gacttccctt atactgtccg tcttgtttca 1653001 gaagtgcttg aatcaaacgg ttctacatct caagcaagca tttgcgcaag cacacttgca 1653061 atgatggatg ccggtgtacc gattaaagcg ccagttgctg gtattgcgat gggtcttgtc 1653121 aaatcaggcg aacattacac tgtcttgact gacatccaag gcatggaaga cgcgctcgga 1653181 gatatggact ttaaagtagc gggaactgaa aaaggcgtaa cggccctgca aatggacatt 1653241 aaaattgaag gcctttccag agagattctt gaagaagcgc ttcagcaggc gaaaaagggc 1653301 agaatggaaa tcctcaacag catgcttgca acattaagcg aatcaagaaa agagctttct 1653361 cgatatgcgc ctaagatctt aacaatgacc attaatcctg ataaaatccg cgatgtcatc 1653421 ggaccaagcg ggaaacaaat caataagatc atcgaagaaa ccggtgttaa aattgatatt 1653481 gagcaggacg gcacaatctt tatttcctct acagatgaaa gcggcaacca aaaagcgaaa 1653541 aaaatcatcg aagaccttgt gagagaggtt gaagtcggcc aactttacct aggtaaagtg 1653601 aaacggattg aaaaattcgg ggctttcgtt gaaattttca gcggaaaaga cggtttggtg 1653661 cacatttcag agcttgcgct tgaacgcgta gggaaagttg aagatgttgt gaaaatcgga 1653721 gacgagattc ttgtcaaagt cactgaaatt gataaacaag gacgagtgaa tttatcccgc 1653781 aaagcggtgc tccgtgaaga gaaagaaaaa gaagaacaac aatcttaaat gaaaacataa 1653841 aaggagcctg ggagacccgg cttctttatt ttgaagcttt tcaaaagcag gcgggttcta 1653901 ccttgtcctt ctccttcata atgtgaggtg agggggggac agaacatgta caaaaaattt 1653961 gtaccgtttg ccgttttttt atttcttttt tttgtctcat ttgagatgat ggaaaatccg 1654021 catgcacttg attatatagg ggcaatgaaa aaagatacgg tgactgtcac ggcgtcaaaa 1654081 gacccgttat atgaagaatt gcttcaaaaa gcgccggagt acgaagttaa gccccagaat 1654141 gcaagaattg ataaagtgtg gaaaagcatt ccaggctaca atggattaaa ggtcaatatt 1654201 gaacaatcat ataaaaaaat gaaacagcat ggtaagtttc gggaaaaaga tttggtgtac 1654261 agtcaagtaa aaccaagtgt tcatcttgag tcacttcagc ctgagcctat ttataaagga 1654321 aatcctgaca aaccgatggt ggctttttta atcaatgtgg catggggaaa tgagtatttg 1654381 gaaaaaatgc ttcctattct gcaaaagcac caggttaaag ctacgttctt tttagaaggc 1654441 aattgggtga gaaacaatgt acagctcgct aagaagattg caaaagacgg acatgaaatc 1654501 ggaaatcatt catacaatca tccggatatg agcaaactga ctacaggaag aatttccgag 1654561 cagctcgaca agactaatga acaaatagaa caaacgatcg gcgttaagcc aaagtggttc 1654621 gctccgccaa gcggaagttt cagaaaagcg gttatcgaca ttgcagcaga gaaacagatg 1654681 ggaacagtca tgtggacagt tgatacaatc gattggcaaa agccggctcc gtctgtactt 1654741 cagacgagag tgttaagcaa gatacataat ggtgccatga ttttaatgca tccgactgac 1654801 cctacggcgg aaagtcttga agcgctgatt acacagataa aagacaaagg atatgcgctt 1654861 ggaacagtca ctgaactaat ggatgaaaca agactattga agtaacagat gaaggcagct 1654921 tgtctttgaa taggaggaac aaatttgatt aaacgatata cgtgtcaaaa tggtgtaaga 1654981 attgtgctgg aaaataaccc gacagtccgt tctgttgcga tcggcgtatg gatcggcaca 1655041 ggttcgagac atgaaacgcc ggagataaac ggaatttctc actttttaga gcacatgttc 1655101 tttaaaggga cgagcacaaa atctgcacgc gagatagcag aatcttttga tcgtattggc 1655161 ggccaggtca atgcgtttac ttcaaaggaa tatacctgct actatgcaaa ggtgcttgac 1655221 gagcatgcga attacgcgct ggacgtatta gcagatatgt tctttcattc aacgtttgat 1655281 gaaaacgagc tgaaaaaaga gaaaaatgta gtatatgaag aaattaaaat gtatgaagat 1655341 gcgccggacg acattgtaca tgatttattg agcaaagcca cttacggcaa tcattcttta 1655401 ggctacccaa ttttaggaac ggaagaaacg cttgcttcct ttaacggtga ctctctcaga 1655461 caatacatgc atgattatta tacgccggac cgagtggtga tttcggtagc gggcaatata 1655521 tctgacagtt ttatcaaaga tgtagaaaaa tggttcgggt catacgaggc gaaaggcaaa 1655581 gcgacaggcc ttgagaagcc tgagttccac acggaaaaac tgacgagaaa aaaagaaaca 1655641 gagcaggctc atttgtgcct tggatttaaa ggcttagagg ttggccatga acgtatttat 1655701 gatttaatcg tcctcaacaa tgtgctcgga ggcagcatga gcagccggct gttccaagat 1655761 gtgcgtgaag ataaaggact tgcttattct gtttacagct atcacagctc atatgaggac 1655821 agcggaatgc taacgattta cggcggaacg ggtgcaaatc agcttcagca gctgtcggaa 1655881 acaattcaag aaaccctggc cacattaaaa cgtgacggca ttacctcgaa agaactggaa 1655941 aacagcaaag agcaaatgaa gggaagctta atgctgagct tagaaagcac aaacagcaaa 1656001 atgagccgaa acggaaaaaa tgaactgctg ctcggcaaac ataaaacatt agatgaaatt 1656061 atcaatgaat taaacgccgt gaacttagag cgtgttaatg gccttgccag acaattgttt 1656121 accgaagact atgcattagc acttatcagc ccttccggca atatgccgtc ttaaaaagga 1656181 aagcctgccc cataatggag caggcatttt ttaatccctt tcatcataca tagtacaagg 1656241 gggtgacaga catgcggctc agtgaattat cgggaaagga aattgtagac atcaaaagag 1656301 ctgaacggct cggagtgctc ggccagaccg atttggaaat caatgaacag gatggacaga 1656361 ttacagcact cctcattccc acagttaagt ggtttggttt gagaaagcaa ggtcatgaca 1656421 ttcgtgtccc atggcaccat attcaaaaga tcggttcaga tatgattata ttagatgtac 1656481 ctgaggaaat gcctcctcga caagagtaaa tagcccaatt gactgtgaag cgggctctaa 1656541 agaaaacatc tgaaacatcg gctgccggag ccgatgtttt tttatatgga aaaagcgcat 1656601 cttttatatt caccggtatt tccttttgat cataagatga aggggagctt aacaactaga 1656661 gatccagtat atacaaagaa ggtgaacgtt tagaatgtta accggattga aaattgcagt 1656721 tatcggcggt gacgcaagac agctcgaaat tataagaaag ctcactgaac agcaggctga 1656781 catctatctt gtcggttttg accaattgga tcacggtttt accggggcag taaaatgcaa 1656841 tattgatgaa attccttttc agcaaataga cagcatcatt cttccagtat ccgcgacaac 1656901 aggagaaggt gtcgtatcga ctgtattttc gaatgaagaa gttgtgttaa aacaggacca 1656961 tcttgacaga acgcctgcac attgtgtcat tttctcagga atttctaacg cctatttaga 1657021 aaacattgca gctcaggcaa aaagaaaact tgttaagctg tttgagcggg atgacattgc 1657081 gatatacaac tctattccga cagtagaagg aacgatcatg ctggctattc agcacacgga 1657141 ttatacgata cacggatcac aggtggccgt tctcggtctg gggcgcaccg ggatgacgat 1657201 tgcccgtaca tttgccgcgc tcggggcgaa tgtaaaagtg ggggcaagaa gttcagcgca 1657261 tctggcacgt atcactgaaa tggggctcgt tccttttcat accgatgagc tgaaagagca 1657321 tgtaaaagat atagatattt gcattaatac cataccgagt atgattttaa atcaaacggt 1657381 actttctagc atgacaccaa aaaccttaat attggatctg gcctcacgtc ccgggggaac 1657441 ggattttaaa tatgccgaga aacaagggat taaagcactt cttgctcccg ggcttccagg 1657501 gattgtcgct cctaaaacag ctgggcaaat ccttgcaaac gtcttgagca agcttttggc 1657561 tgaaatacaa gctgaggagg ggaaataagg atgtcgtcat taaaaggaaa aagaatcggg 1657621 tttgggctga ccgggtcgca ttgcacatat gaagcggttt tcccgcaaat tgaggagttg 1657681 gtcaacgaag gagctgaagt ccgtccggtt gtcacattta atgtaaaatc tacaaatacc 1657741 cgatttggag agggcgcaga atgggttaaa aaaattgaag acctgactgg atatgaggcc 1657801 attgattcga ttgtaaaggc agaacctctt gggccgaagc tgccccttga ctgcatggtc 1657861 attgcgcctt taacaggcaa ttcaatgagc aagctggcaa atgccatgac ggacagcccg 1657921 gtgctgatgg cggcaaaagc gacaatccgg aacaatcggc ctgtcgttct gggtatctcg 1657981 acaaatgatg ctcttggttt aaacggaaca aatttaatga ggctcatgtc aacaaaaaat 1658041 atctttttta ttccattcgg gcaagatgat ccatttaaaa aaccgaattc aatggtagcc 1658101 aaaatggatc tgcttccgca aacgattgaa aaggcactca tgcaccagca gcttcagccg 1658161 attctagttg agaattatca gggaaatgac taaatttaca gaaaatcttt cccaaactaa 1658221 aaaattcggt catcacccgc atattctatg gtaaaataaa acgtaaaatc atagtcaaat 1658281 caattcaatg aagctgattg gcggaaggag ttttacagat gggaagaggt ttacacgtag 1658341 ctgttgtcgg agcgacaggg gctgtgggac aacaaatgct taaaacactt gaagacagaa 1658401 actttgaaat ggacacactt acattgctat cttcaaaacg ctctgcgggg acaaaagtca 1658461 cgtttaaagg ccaagagctg actgttcagg aagcttctcc tgagagcttt gaaggggtaa 1658521 atattgcttt gttcagcgcc ggcggaagcg tatcacaagc attggcacca gaagctgtaa 1658581 aacgcggcgc tattgttata gataatacga gtgcgttccg catggatgaa aatacaccgc 1658641 ttgttgtgcc agaagtgaat gaggcagact tgcatgaaca caacggcatt attgccaatc 1658701 caaactgctc tacaatccaa atggttgcgg cacttgaacc gatccgcaaa gcatatggct 1658761 taaacaaggt catcgtatca acttaccagg cagtatcagg agcgggtaat gaagctgtaa 1658821 aagagcttta cagccaaaca caggcgattt taaataaaga agaaatagag cctgagatca 1658881 tgcctgtaaa aggtgacaaa aaacactatc aaatcgcctt caacgcgatt ccgcaaatcg 1658941 ataaattcca agataacggc tatacgtttg aggaaatgaa aatgataaat gaaacgaaaa 1659001 aaatcatgca catgcctgac cttcaagtag cggctacatg tgtgagactg ccaatccaaa 1659061 ctgggcactc agagtccgtc tacatcgaaa tagaccgtga tgacgctaca gttgaagata 1659121 ttaaaaatct attgaaagaa gctccgggcg tgacacttca ggatgatcca agccagcagc 1659181 tttatccgat gcctgctgat gctgtcggca aaaacgatgt gtttgtaggc cgcatccgca 1659241 aagacttgga cagagcaaac ggttttcatt tatgggttgt ttctgataac ctattaaaag 1659301 gcgcggcatg gaactctgtt caaattgcag aaagcctgaa aaaactaaac ctcgtataaa 1659361 agagagaatt ttctaaagac gaatagaaga gagtaaggcg ctatcagcct gctctcttct 1659421 gttacgtccg aataatttgg agtgaaaaca gtgaagataa ttgttcaaaa gttcggcgga 1659481 acatcagtaa aagatgataa aggccgcaaa ctggctttag ggcatattaa agaagcaatc 1659541 agtgaaggat ataaggttgt cgttgtcgtt tcagcgatgg gccgaaaagg ggacccgtat 1659601 gcaacagatt ctttgctcgg gctgctttac ggcgatcagt cagcgatttc tcctagggag 1659661 caggatttgc ttttatcttg cggagagact atttcctctg tcgtctttac aagcatgctg 1659721 cttgataacg gtgtgaaagc agctgcgctg acaggggctc aggctggctt tttaacgaat 1659781 gatcagcata ctaatgcgaa aatcattgaa atgaaaccgg agcgtttatt cagtgtgctc 1659841 gccaatcatg atgcggtagt cgtcgcaggc ttccagggcg caactgaaaa gggtgataca 1659901 acaacaatcg gcagaggggg cagcgatacg tctgcagccg cactcggagc agctgttgat 1659961 gcggaataca tcgatatttt caccgatgta gaaggcgtga tgactgctga cccaagagtg 1660021 gtagaaaatg caaaaccgct tcctgttgtg acgtatacgg aaatctgcaa cctggcgtat 1660081 cagggggcca aggtcatttc tccgcgtgct gtggaaatcg caatgcaggc caaggttccg 1660141 atccgcgtcc gttcgactta ttcgaatgat aaaggcacat tggtgacatc acatcactct 1660201 tccaaggtcg gcagtgatgt ttttgaaagg ctgattacgg gaatcgccca tgtcaaagat 1660261 gtcacgcagt tcaaagtgcc tgcgaaaatc ggccagtata acgttcagac tgaagtgttc 1660321 aaggctatgg caaacgctgg aatcagtgtc gatttcttta acattacacc tagtgaaatc 1660381 gtctatacgg tagccggaaa taaaacagaa acagctcagc gtattttaat ggatatgggc 1660441 tatgatccaa tggtgacgag aaactgcgcg aaggtatcgg cggtcggcgc gggcattatg 1660501 ggtgttcccg gtgttacgtc caaaattgta tcggctcttt cagaaaaaga aattccgatc 1660561 cttcagtcgg ctgacagcca tacgacgata tgggtgctcg tccatgaagc ggatatggtt 1660621 cctgctgtaa acgctttgca tgaagtgttt gaactttcga agtaaatgtg attgaatcat 1660681 gatgaggtga ataaaatgaa tttcggaaat gtgtctacag cgatgattac accctttgac 1660741 aataaaggga acgtagactt tcaaaaactg tctacactga ttgattactt gttgaaaaac 1660801 ggaacggatt ctttagtagt agcgggaaca actggagaat ctccgaccct ttcaactgaa 1660861 gaaaaaattg cgctttttga atatacggta aaagaagtaa acggacgggt gcccgttatc 1660921 gctggtactg ggagcaacaa cacgaaagat tccattaagc tgacaaaaaa agctgaggaa 1660981 gcgggcgtgg acgctgttat gcttgttacc ccgtattaca ataaaccttc tcaagaagga 1661041 atgtaccagc attttaaagc aattgcggca gagacatctc ttccggttat gctctataat 1661101 gttcctggcc gtacggttgc ttctcttgct cctgaaacga cgatccgttt ggcggcagac 1661161 attccgaatg tggttgcgat taaagaagcg agcggagacc tcgaagcgat tacaaaaatt 1661221 attgctgaaa cacctgaaga cttctatgtc tattcagggg atgatgctct aacgcttcca 1661281 attctttcag ttggaggtag aggagttgtg tcagtggcga gccatattgc aggcactgat 1661341 atgcagcaaa tgatcaaaaa ttatacgaat gggcaaacag ctaatgcggc actgattcat 1661401 cagaaactgc tgccgattat gaaggaactg tttaaagcgc ctaatcctgc tccagtcaaa 1661461 acagcgcttc agctgagagg tcttgatgtc ggttctgtgc gtctgcctct agtcccatta 1661521 actgaggatg aacgtctgag cttaagcagc acgatcagcg aactgtaaga aaatttcata 1661581 cagtgaaaca aacgcggtca ttctcacatt cagctgagtt tgaccgtttc ttttacatat 1661641 tggttttccc taaaccttct gctttatctt gttttctaaa tttactttca gttataatag 1661701 gaacaagtga tgatggacgg gtatgagact aggaggatat agattttgaa aaagaaaaat 1661761 acagaaaacg ttagaattat cgcccttggc ggtgtcggag agattgggaa gaacctttat 1661821 gtcattgaaa ttgactcaga catatttgtc gttgatgccg gccttatgca tccagaaaac 1661881 gaaatgctcg gtattgatgt agtgattcct gacatatcat atttgattga acgggctgac 1661941 cgcgtcaagg caatcttttt aacgcacggg cacgatgaaa atatcggcgg cgttttttac 1662001 ttattaaaca agctgtccgt tccagtgtac ggaacaaaac tgacgcttgc actgttaaga 1662061 gagaaattaa aacaatacgg acataaccga aaaactgatt taagagaaat tcactccaaa 1662121 tctgtcatta catttgaatc aacaaaggta tcgttcttta gaacgattca cagcattcct 1662181 gattctgtag gtgtgagctt taaaacatca cttggatcta ttgtatgcac gggagacttc 1662241 aaatttgacc aaacacctgc acttaatcag acgtgcgaca ttggcgagat cgccaagatc 1662301 ggcaatagcg gcgtgctcgc tctgctttct gacagtgcaa atgcggaacg gccgggttac 1662361 accccttcgg aagcggctgt cagcggagaa atttcggatg cgctgtataa ttcacagaac 1662421 cgggtgatta ttgctgtttt cgcatccaat attaaccgga ttcagcaagt cattcatgca 1662481 gcggctcaaa atggcagaaa gattgccgta gccggaaaaa atcttcaatc tgtcctgcag 1662541 ctggcgagaa agttaggata tattgaagca gatgatgaat tgtttatttc tgtacaggat 1662601 gtcaaaaaat atccgaagcg cgaagtggcc attattacag ccggaagcca aggtgaacca 1662661 ttagctgctt tgacaagaat ggcaaacaaa gctcacaaac agctgaacat tgaagaaggg 1662721 gatacggtgg tcattgcgtc aactccgatt cccgggcagg aactcattta ctctaaaaca 1662781 gtagatcttc ttgcgagagc cggtgcacaa gtcatctttg cccaaaagcg tgttcatgta 1662841 tcaggccacg gctcacaaga agagttaaag ctgatgatca acctgcttaa accaaaatat 1662901 ttgattcctg taaacggcga atacagaatg caaaaagctc attcaaaaat cgctgaagaa 1662961 accggcatga agcgcagtga catcttctta attgaaaaag gcgacgtcgt tgaattccgc 1663021 ggccaaaacg taaaaattgg ggataaagtt ccttacggca atattttaat tgatggttta 1663081 ggtgtcggtg atatcggcaa tatcgtattg agagaccgcc gcttgctttc acaggacgga 1663141 attttaatcg ttgtcattac acttgataaa caaaagaaac atcttgtatc aggaccagaa 1663201 attatcactc gcggctttgt ttatgtaaga gagtctgaag gtcttatcgt acaggctact 1663261 gagcttgtac ggtccatcgt gacagaagcg actgaaacat caaatgtcga atggtcaacg 1663321 ctgaagcagg caatgcggga tgctttgaac caattccttt atgaaaaaac gaaacgtaaa 1663381 ccgatgatca tcccaattat tatggaagta taatgactga ctaaagaccg gagctgctcc 1663441 ggtctttatt ttttgtcctt caagccggga ttgaatgaag tatctttgtt cataatacaa 1663501 agagaaactc ggaaaggatg aaagcgagat ggatcatcgt atggaaaaca cagaagaaga 1663561 gcgtcctgaa aaaaatgatg cgaaggacag cattatgaat aaaatacagc agcttggtga 1663621 aacgacgctt ccgcagctgc cccaagatac aaatattcat tgtctgacca ttatcggaca 1663681 aattgaaggc catgttcagc ttcctccgca aaacaaaaca acaaaatatg aacatgtcat 1663741 cccgcagatt gtggcaattg aacaaaatcc caaaattgaa ggcttgctga tcatattaaa 1663801 tactgtcgga ggagatgttg aagctggtct tgccatagcg gaaatgcttg catctttatc 1663861 gaaaccgacc gtttctatcg tgcttggcgg ggggcattca atcggcgttc cgattgctgt 1663921 atcctgtgat tacagctata tcgccgaaac agcaacgatg acgattcatc cagttaggct 1663981 caccgggctg gtcatcgggg tgccgcaaac gtttgaatac ctggataaga tgcaagaaag 1664041 agttgttaaa tttgtgacaa gccattccaa tataaccgaa gagaagttta aagagctaat 1664101 gttttcaaaa ggaaacttaa cacgcgatat cggaacaaat gtagtcggta aggatgcagt 1664161 taaatacgga ttgatcgatc acgcaggcgg tgtcggacag gcaatcaata aactgaatga 1664221 gctcatcgat gaagcaagga aagaagaagg acggatgatt caatgattct ttataccgtg 1664281 atgcctcagg aaattgtgtt tgcagaacag aaccaagaga caagcgcaca tgagcaaatt 1664341 gaatataaag gtgtaccgct tctagtcgaa atgaaaggga atgaagcgga agtcattcaa 1664401 atcatgagca ccaatccaat gcattttctg catccggaca tttcaccggg acaaaagctg 1664461 aaattaaacg tataagaatc caaccctttt ttaagggcaa aatatgctat aataggggaa 1664521 tcctacagaa aaaacgcagc ctgtaaacgg ctgctttctt cattatgtat gaacttacat 1664581 tttttaacgc agtaaggtga tgagtgtggc aaagaaaaaa cgaaaatcaa gaaaaaaaca 1664641 ggcgaaacag ctcaatataa aatacgagct caacggattg ctgtgtatag ccatttcaat 1664701 tatcgcaatc ttgcagctgg gggtagtcgg gcaaacgttt atctatttgt tccgcttttt 1664761 tgctggagag tggtttattt tatgcttgtt aggtttattg gtgttaggag tctcactgtt 1664821 ttggaagaaa aaaaccccaa gccttttaac gagacgaaag gccgggttgt actgtattat 1664881 cgcaagcata ttgctgcttt ctcacgtgca gctatttaaa aatttgacgc acaaagggtc 1664941 tattgagtct gcaagcgtgg tgcgcaatac gtgggaattg tttttaatgg acatgaatgg 1665001 cagctctgct tcacctgatt taggcggagg gatgatcggt gcgctgctgt ttgcggcttc 1665061 acactttttg tttgcgtcga ctggttctca gatcatggca attgtcatga ttttgatcgg 1665121 aatgatttta gtaacaggac gctcgctgca agaaacgcta aaaaagtgga tgagcccgat 1665181 tggacgtttt ataaaagaac aatggttagc atttattgat gacatgaaat ccttcaaatc 1665241 aaatatgcag tcatcgaaaa aaacgaaagc gccgagcaaa aaacaaaaac cggcccgcaa 1665301 aaaacagcaa atggaaccgg agcctcctga tgaagagggg gattatgaaa cagtatcgcc 1665361 tcttattcat tcagagccga ttatctcaag cttttctgat cgtaatgaag aggaagagtc 1665421 tccagttata gaaaagcgcg ccgaacctgt gtcgaagccg cttcaggaca tccaaccgga 1665481 gacaggtgat caggaaactg tttctgctcc tcctatgacc tttacagagc tcgaaaataa 1665541 ggattacgag atgccgtcac tggatttgct ggcagatccg aagcataccg gccagcaggc 1665601 tgataaaaag aatatttatg aaaatgcgag aaagcttgaa cgcacattcc aaagctttgg 1665661 cgtaaaggcg aaagtcacac aggttcatct cggaccggcc gtaacaaaat atgaagtata 1665721 tcctgatgtc ggagtgaagg ttagcaaaat tgtcaattta agcgatgatt tagcgcttgc 1665781 gcttgctgcg aaggatatca ggatcgaagc gcctatacca ggcaaatcag caatcggaat 1665841 tgaagttcca aacgcagaag tggcaatggt ttcgctgaaa gaagtgctgg agtctaaatt 1665901 gaatgacaga ccggatgcga agctgttaat tggactcggc cgcaatattt caggtgaagc 1665961 tgtattggct gagttaaaca agatgcccca ccttttggtc gcaggcgcaa ccggtagcgg 1666021 gaaaagtgtc tgtgtcaacg gcattattac aagtatttta atgcgggcga aaccgcatga 1666081 agtgaaaatg atgatgatcg atcctaaaat ggtagagcta aatgtctaca acgggattcc 1666141 gcatttgctt gctcctgttg taaccgatcc gaaaaaagcg tcgcaggctt tgaaaaaggt 1666201 tgtcaatgaa atggagcggc ggtacgaatt attttctcat acgggtacaa gaaatattga 1666261 aggatacaat gattatataa aacgcgccaa caatgaagaa ggagcgaaac agccagagct 1666321 gccttatatt gttgtcattg tggacgagct agccgatctc atgatggtcg cttcatctga 1666381 tgtggaagat tcgattacga gattgtccca aatggcgcgg gctgccggca tccatcttat 1666441 tattgcgaca cagcggccat cggtggatgt tatcacaggg gtgatcaaag cgaacattcc 1666501 gtcacgaatc gcgttcagcg tatcttcaca gacggattca aggaccattc ttgacatggg 1666561 tggcgctgag aagcttcttg gccgcggcga tatgctgttt ttacctgtag gggctaacaa 1666621 acctgtccgt gtgcagggag catttttgtc ggatgacgaa gtggagaagg tcgtcgacca 1666681 tgtgattact cagcagaaag cgcaatatca agaagaaatg attcctgagg agacgacgga 1666741 aactcattcc gaggttactg atgaacttta tgatgaagct gttgaattaa tcgtcggcat 1666801 gcagacggca tctgtttcaa tgctgcaaag aagattcaga attggctata cgagagcggc 1666861 gcgcctgatt gacgcaatgg aggaacgcgg tgttgtcgga ccgtatgaag gcagcaaacc 1666921 tagggaagta ttattatcaa aagagaaata tgatgagctc tcttcttaat gaagggagtt 1666981 ccgctttcta tagttgtcaa taatgatatt atgtaaactg atcacctttc tatttatttt 1667041 ttcgacaaaa catgatatag ttgtcccaat tgttcaataa tttttatcga aagtggttta 1667101 cggaggggaa acatgtctac aaaagctgat aatcggcact tgtatttgaa agtaattgaa 1667161 cgaattaaag aggatataaa aaatgggatc tacactgaga aggaaaagct gccttctgaa 1667221 tttgagcttt ccaaaaagct tggtgtcagc agagcgacgc taagagaagc cttgcggata 1667281 ctggaagaag agcatgtgat tatcagaagg catggtgtag gcacttttgt ccattctaag 1667341 ccgttatttc tttcgggtat tgaacagctg aacagtgtaa ccaagatgat agaacaggcg 1667401 aatatgaccc ctggcacgat ttttctatca tcacaagtgc ttatgccgtc tgaagatgat 1667461 acgaagagat ttcacttggc agaagggcaa gaactttttt accttgaacg agtcaggaca 1667521 gctgacggac agccgattgt gtattgtata gacaaaattc cgatgaatat tttgccgaat 1667581 tctttttctc atcagcaaga atctatgttt gacctgctag agaaaaattc aggctccgta 1667641 atcagctatg cagtaactga tatagaaccg atcggctatc acgataccat ttctccagtg 1667701 cttgaatgcg atccggaaac agctcttttg ctgttaaaac aaacccatta cgatcagcac 1667761 gataaaccgg tgctttattc tttaaattat tttagagcgg ataaattcag atttcatgtt 1667821 ttgcgtaaac gattctaaaa acggacgcct gtatgtgtct gtttttttat ttgcactgat 1667881 tcatgtttct ttgtacatac tttcattccg gttaacgcaa tatataaggg atgacaagaa 1667941 agtgaatggg tgaaaatgtt gagagagaaa aatggaatga aaaatattat tgcattgtct 1668001 tctgtcccgc ttgtgatgac actcgggaac tccatgctga ttcctgttct tccgatgatg 1668061 gagaaaaagc tgtctgtgac ttcatttcaa gtatctttaa tcattactgt atattcagta 1668121 gtagcaatta tttgcattcc gattgccgga tatttgtcgg atcgtttcgg gagaaaaaaa 1668181 atattgcttc catgcctcct cattgcagga ttggggggag ccgtagctgc ttttgcctcg 1668241 acctatatga aaaatcctta tgctatgatc ttggcggggc gggttcttca aggcattggt 1668301 tctgcaggtg ccgctccgat tgtcatgccg tttatcggcg acctgtttaa aggagacgat 1668361 gaaaaggtca gcgcgggtct tggcgatatt gaaaccgcca acacgtcagg gaaggtactg 1668421 agtcccatac ttggagcctt actggcttct tggtattggt ttgtaccgtt ttggtttatt 1668481 ccgtttttct gtttgatcag ctttttgctc gtattgtttt tggtggccaa gcctgaagaa 1668541 gatgaagatg cgcctgctgt ttctgagttt attaagagtg tgaagaaaat ttttaaacag 1668601 gatggtcgct ggctttatac ggtcttcatt atcgggtgtg tcattatgtt tttgttattt 1668661 ggcgtattat tttatttatc agatacgctg gagaacaagt atgctattga cggagtagct 1668721 aaaggcggat tactggcaat cccacttttg tttttgtcaa ccagttcttt tatagctggc 1668781 aaaaagatcg gtaaagataa aggccgaatg aaattttgcg ttgttacagg aatgattctg 1668841 ttaacccttt cgtttattgc cttgtggtgg aaccacagtt tttatttttt atttgtcttt 1668901 ttaagctttg gcgggattgg gattggaatg gctcttcctg ctttagatgc attgataacc 1668961 gaagggattg aaagtgaaca atgcggaacc atttcctcct tttacaatag catgcgcttt 1669021 ataggagtag ctctcggtcc acctgttttt gctgcattaa tgtctaatgc aaactggatt 1669081 attttcatac tctcggcgtt ttgcagcatc gtttctttat ttttagtgct ctttactgta 1669141 gatgctaaaa aaagtgaaga agaaaaaaac ttagggacgg tctagccagc cgtctttttt 1669201 tgcgctttct tgcacagttt acaactgtac ctatacagca tgcggaggtt attgtttcct 1669261 tataaatcct acagttgcta taattacatg aaagagtgtt tctgcggatg ctgaaaattg 1669321 gtcataatac atactaatta agaaatgaac gaaggaggtt ccatatgtca tatgttaatg 1669381 aactcaaatc aaagcacggc ggtttaaccg cacacattgt aaaaacagaa aaattcaaaa 1669441 ccgtctcgct tatttttaag atgcttgcgc cgctgacaaa ggatcaagtc accaaaagag 1669501 cgcttctccc gcatgtgctt cttcgcggaa cgaaaagcca tccgaaaacc gcaggattgc 1669561 gttcatactt ggatgagctg tacggcacgt cagtatcggc tgatcttacg aaaaaaggag 1669621 agcggcatgt cattacgttc aggcttgaaa tcccgaatga aaaatattta aaagaccaaa 1669681 cgccgcttct cgagaaaggg ctccagcttc tcgcagaact cgtcttttca cctgctttgg 1669741 agggagacgc ttttcagtca caatatgtgg ctcaagaaaa acggacgctt aagcaaagaa 1669801 tccaagccgt ctatgatgat aaaatgcgtt attcgaattt aaggctgata caggaaatgt 1669861 gcaaaaatga tccttacgcg cttcatgtca atggtgaaat cgacgatgtc gatgacatta 1669921 cggcagagca attatacgaa acataccaaa gcgctatcca aaaagaccag cttgatctat 1669981 atgttgttgg cgacgtggac agtaaccagg tacaatcggc aattgataag tatttcaaaa 1670041 cagaagagcg cactcttggc atgattgaaa acaatcacgc tgatgaaaaa gttcagccaa 1670101 aagaagtaat tgatgaagag gatgtcaagc aaggaaaact gaatatcggc taccgcacca 1670161 gcatcactta tacagatcag gattatcctg ctttacaagt gtttaacgga ttgttcggcg 1670221 gattctctca ttctaaactt ttcattaatg ttcgggaaaa agccagtctt gcttactacg 1670281 cggcttcgcg tatagaaagt tttaaaggct tgttaatggt gatgtcaggc attgaagtga 1670341 aaaattttga acaggcggtt tcgattattg ctgagcaatt ccaggcaatg aaaaatggcg 1670401 atttcagtga gcaggatata gcacagacaa aggccgttat tcgaaatcaa gtgctggaaa 1670461 cgattgatac agcatacggt ttatctgagt ttttatatca gcaggccgct gctcaagtcg 1670521 agattcctat cgaagacttt cttgccaata ttgagaatgt cacaaaagag gatatcatta 1670581 aagccggcga aaagattcag cttgatacga cttatttctt aaaagggacg gagggtgcat 1670641 cttgatcaaa ccaatcgaat atgaacagct tcaggagacg ctgtatcatg aaaaaatgtc 1670701 caacggcctt gatgtttacg ttttgccgaa aaaaggcttc aacaagacat atgcggtctt 1670761 tacaacaaag tacggctcga tagataaccg gtttgtccct ttaggtaaaa acgagatggt 1670821 tcacgtgccg gacgggattg ctcactttct tgagcacaag ctgtttgaga aagcggacgg 1670881 agacgttttt caagatttca gcaaacaggg ggcttctgcc aatgcgttta cgtcatttac 1670941 aagaacggct taccttttct caagcacatc aaatgttgaa cgcaatttag agacgcttat 1671001 cgatttcgta caggacccat attttactga aaaaacggtt gaaaaggaaa aagggattat 1671061 cgggcaggag attaatatgt acgacgataa ccctgattgg aggctttact tcggggtcat 1671121 tgaaaacatg tacaaagagc atcctgtcag aattgacata gcgggaacag tggaaagcat 1671181 ttcacatatt acaaaagacc ttctttatga atgctatgaa acgttttatc acccgagtaa 1671241 catgctcctt ttcattgtcg gccctgtaga tcctgaagcg attatttctc aggtaagaga 1671301 aaaccagggg aaaaagccgt atactgatca gccggagatc aaacgagaag aagtgaaaga 1671361 gcaagaagcg gttttccgaa aagaaaaaga gatcaaaatg aacgtgcagg gaccgaaatg 1671421 ccttgttggg ctgaaatcca aaaatccgtt taaattaggc aaagagctct taaagcatga 1671481 actttcaatg aacttattgc ttgaagctct ttttggcaaa agctctgccc agtatgaatc 1671541 actttatgaa aaaggatata ttgacgaaac gttcagcttt gattttactg ctgaatatgg 1671601 gttcggtttt gcggcgatcg gcggagatac gcctgagcct gatcaattgg ctgaagacat 1671661 ttcaagcatg cttttgcgcg ccggtgaact gattactgct gaaaagattg aacttgccag 1671721 aaagaaaaag atcggcacat tcttaaaagc gctgaattcc cctgaataca tcgccaatca 1671781 atttacccgt tatgcgttct tggatatgag cctgtttgat gttgtaacgg tactcgagca 1671841 gattaccctc gaggatgtcc agaacgtaat acaagaggaa atcgctgcag acagactgac 1671901 tgtctgcaag gttgttccta aatcataaac aaaacatccc tccagtgtga ggggtgtttt 1671961 tctgcggaaa gaaggaaaga ggatgaacaa aacagcacta atcaccggag caagcggcgg 1672021 cattggcaaa agcatcagcg aaacccttgc agctagagga tacaatctgc tgctgcatta 1672081 caatacaaat caaaacgcgg cagcggagct tgctgaaaaa ctaagtcaga tgtttggcgt 1672141 aaatgcggag atattacaag ctgacctgtc cgcgcaagat ggagcagata agctgacaag 1672201 ttcaattgtt cagccgattg atgcgattgt tttaaacagc ggacgaagcc attttgggct 1672261 gattacggat gtagataacg caacggtcca ggaaatggtt cagcttcatg tggcgagtcc 1672321 gtatatgctg acgagaaacc ttctgccagg catgattcgg aataaatcgg gagcgattgt 1672381 ggctgtcagc tcgatttggg gagagactgg agcatcctgt gaagtgttgt acagcatggc 1672441 aaaaggagct cagcattcat ttgtaaaagg attggctaag gagctggcgc caagcggaat 1672501 cagagtaaac gccgtagcgc cgggtgcagt tgatacaaat atgatgaatc aatttacccc 1672561 ggctgaaaaa gaagagatcg ctgatgagat tccgatcggc cggctggccc ggccgcaaga 1672621 aattgcggat gcaacagctt ttctcctgtc tgaaaaagcg tcatatatca ccggccaaat 1672681 tctgtcggtg aatggcggct ggcactgctg atccgaaaat attcggtgta tagtttcttt 1672741 tgcgaaggac acaataatct tgtaacttca catgaaatgg aggaaacaag catgtcagta 1672801 ttagaaaact gggatagctg gaaaaacttc cttggcgacc gtctgaacta tgcgcaagat 1672861 aaaggtatga gccaggatac gattacagat cttgcgacag aaatcggcag ctacttggct 1672921 aatgaagtgg aatctaagaa cgagcaggaa aaagtgctgg cagatctttg gagtgtagca 1672981 tcaaaagatg aacagcacgc cattgccaat atgatggtta agcttgttga aaataacagc 1673041 actcactagg aagagagggg atttttcctc tcttttttat gttttcctca tcacagcaac 1673101 attcttcttt ctaattagag aaaaatgctt tatgataaag gaaggtaaaa ttttgccaca 1673161 atgaaggggg tatatcattt ggcaaagctc gaatggtatt ttgaatatga aattcaagtg 1673221 aaccgccccg gactgctcgg ggatatttca tctcttcttg ggatgctttc tatcaacatc 1673281 gtaacgataa acggcgtcga tctttccaga aggggaatgc tcctcaggtg ccgccatata 1673341 gatcaaatta aacgattaga atcaatctta aaaacgatgg aaacaattaa agtaacgaag 1673401 cttagagaac cgaggcttcg cgaccgtctt gccgtacgcc acggccgtta tattcaacgg 1673461 gatgccgatg acaagaaaac gttccgcttt gaacgggacg agcttggctt attagtcgat 1673521 tttatggccg aattgttcaa aaaagaaggc cataaattaa tcggaatcag aggtatgccg 1673581 cgtgtcggga aaacggaatc gattgtagcc tctagtgtgt gcgagcaaaa ggtggctgtt 1673641 tgtgtcatca accttgctga agcagacgat aagaagccag ctgattgccg atgaatacag 1673701 cactgaaaat gtctttatcg ttgacggaat tgtgtcaaca cgaagagggt cagaacgcca 1673761 tctccagctg gtccgagaaa tcatgcggct gcctgcaaca aaagtggtgg agcatccgga 1673821 catattcgtt caaaatacag agtatacact agatgacttt gattatatta ttgaactgag 1673881 aaatgaccct gatgaggtta ttacatatga acatgccgag gaaccccaaa tgtttgatca 1673941 atccgggttt tcaagctttg atttttaaaa ttggaaggtg tttgttgtga ctgaactagg 1674001 aatccggctc aaagaagcca gagaggaaaa agcaatgtca ttggatgatc tccaagcggc 1674061 aacaaagatt caaaaaaggt atttaaccgc cttggaggaa ggaaactatg acattattcc 1674121 ggggaagttt tatgttcggg cattcatcaa gcaatatgca gaagccgttg ggcttgatgc 1674181 ggatcagctg tttgaggagc ataaaaaaga tatccctaat acgtatcatg atgatgtgtc 1674241 tgaaaagatc tccggcatga atcttcaaaa ggaaatgcca aagccagcat ctaaggcgct 1674301 ggagctgctg ccaacaatac ttgttattct cggcgtgatt gtcgtgattg ccattgtgta 1674361 cgcgatcatt caatttgcca atcacaaaaa cagtgatgat cacaatgcgg catcagaaaa 1674421 agcaattacg caaagtgaga gcaagtacga aatccctaaa gattcaacgc tgaaagagaa 1674481 tcaaaataac agctctgaaa aagagacaga cactaaaaaa gaaacgaaag aaaacgaaga 1674541 taagaaaaaa gaaaatgaca gtgagaagct ggagattaaa gctgctggca ctgaaggatc 1674601 gttaacgact tatgaagtgt ccggcgctga taaaatcgag ctggaactga aggcatcaga 1674661 cagctcctgg attagagtgc gcgatgaaaa cagcagctct ttaaaagaag gaacgctgaa 1674721 aaaagacgaa acctataaaa aagacataac tgatcagaaa caagttgata tccgcaccgg 1674781 atatgcacct aatctgaaaa taaaaatcaa cggtaaggtt ctttcatatg aacttgatcc 1674841 gaaaaaagtg atggcacaaa ccataaagat tgtaaataaa aaggaagaaa agtcatctta 1674901 attaccagat gacttttctt cacgtccgag tatgaaattg gaggggcttt atgtttaact 1674961 taccaaataa aatcacacta gctagaatcg cattaatccc aatcttcatg attatcatgc 1675021 tggcgccgtt tgactggggc aggctcgaag ttggagacga atccatcccg gtcgcacatt 1675081 tggcgggggc cattctattt attattgcat ctacaacaga ctgggtggac gggtattatg 1675141 cccgaaaatt aaatctcgta acaaacttcg ggaaatttct tgatccgctt gcggacaaac 1675201 tgctcgtatc cgcagcgtta attatccttg ttcaatttga tctcgctcca gcttggatgg 1675261 tcattgtgat tatcagcagg gagtttgccg tgacaggttt aaggcttgtc ttagccggaa 1675321 caggagaagt cgtagctgct aacatgcttg gtaaaatcaa aacctgggca cagattattg 1675381 cggtatctgc attgcttctt cataatcttc catttgaact tgtgtcattc ccgtttgcag 1675441 acttggcgct gtgggtagcc gtcttcttta ctgtcgtctc aggctgggaa tatttctcta 1675501 aaaattggga agcgttaaaa acatctaact aagaaagaag gacttcgtca tggaatttcc 1675561 aaaaaaagca gaaataattg cagtcggttc agagttgctg cttggtcaaa tcgccaatac 1675621 aaatgctcaa tttatcagca aacagctcgc tgaaatcggg gtcaacgtat tttatcatac 1675681 agcggtcgga gataacccgg agcggctgaa gcaggtcatc cgcattgctg aagaacgctc 1675741 tgacttcatt attttttcag gagggcttgg acccacaaaa gatgatctga cgaaagaaac 1675801 gattgcaaat acgctgggac gtccgcttgt gttaaatgat gaggcattcc aatccattga 1675861 ggactatttc aaacgaacaa aacgcacgat gtcacctaat aaccgaaaac aggcgcttgt 1675921 gatcgaaggc tctgacgtgc tggcgaatca ctttggaatg gccccgggaa tgctcacaga 1675981 gcatgaatcg cgctattata tgcttcttcc tggaccgccg agcgaattgc gtccaatgtt 1676041 tgaaaacgag gcaaagcctc ttctgctgaa aaagatgggt tcaaatgaaa aaattgtgtc 1676101 aactgttctt cgctttttcg gtatcggtga atctcagctt gaagccgatt tggaagatat 1676161 tattgatgca caaaccaatc cgacaattgc gcctttggcg gctgatggag aggtgacgct 1676221 gcgtctgaca gccaaacacg ccgatgaaaa ggaaacagag cgtctgttaa aagaaacaga 1676281 ggccgttatc ttagagcgtg tcggtgaatt tttctatggt tacgatgata cttctcttgt 1676341 aaaagagcta tctatagcat gtaaggaaaa aggcataaca atttctgcgg cagaaagctt 1676401 taccggaggg ctgttttctg aatggctgac ggatcatagc ggtgcctcaa aattatttgc 1676461 cgggggcgtt gtttgctata caaacgacgt gaagcagaat gtgcttggtg tcaagaagga 1676521 aacattagat cgttttgggg cggtcagcaa ggagtgcgca tccgaactgg ctaagggtgt 1676581 tcaaaaactc actggcagcg atatcggcat tagctttact ggtgtagcag gacctgatgc 1676641 tcaagaaggg catgagcctg ggcatgtgtt tatcggcatt tccgcaaatg gtaaagaaga 1676701 ggttcacgag tttcactttg cgggctccag aacggggatc agaaaacgcg gcgctaaata 1676761 cggctgccat ttaatcttaa agcttttaga gcaaaaataa tattttcagc acattatcct 1676821 cctaagaaaa catgatttct ctgatacatt atgatatttt gataggaatc acgccaagaa 1676881 aaaatccgaa tatgcgttcg cttttttctt ggcaaatccc ttcaaacagg gtatagtata 1676941 tgtagtggta acataaagga ggaaaaaata gaatgagtga tcgtcaggca gccttagata 1677001 tggctcttaa acaaatagaa aaacagttcg gcaaaggttc cattatgaaa ctgggagaaa 1677061 agacagatac aagaatttct actgtaccaa gcggctccct cgctcttgat acagcactgg 1677121 gaattggcgg atatcctcgc ggacggatta ttgaagtata cggtcctgaa agctcaggta 1677181 aaacaactgt ggcgcttcat gcgattgctg aagttcagca gcagggcgga caagccgcgt 1677241 ttatcgatgc ggagcatgcg ttagatccgg tatacgcgca aaagctcggt gttaacatcg 1677301 aagagctttt actgtctcag cctgacacag gcgagcaggc gcttgaaatt gcggaagcat 1677361 tggttcgaag cggggcagtt gacattgtcg ttgtcgactc tgtagccgct ctcgttccga 1677421 aagcggaaat tgaaggcgac atgggagatt cgcatgtcgg tttacaagca cgcttaatgt 1677481 ctcaagcgct tcgtaagctt tcaggggcca ttaacaaatc gaagacaatc gcgattttca 1677541 ttaaccaaat tcgtgaaaaa gtcggtgtta tgttcgggaa cccggaaaca acacctggcg 1677601 gccgtgcgtt gaaattctat tcttccgtgc gtcttgaagt gcgccgtgct gaacagctga 1677661 aacaaggcaa cgacgtaatg gggaacaaaa cgaaaatcaa agtcgtgaaa aacaaggtgg 1677721 ctccgccgtt ccgtacagcc gaggttgaca ttatgtacgg agaaggcatt tcaaaagaag 1677781 gcgaaatcat tgatctagga actgaacttg atatcgtgca aaaaagcggt tcatggtact 1677841 cttatgaaga agagcgtctt ggccaaggcc gtgaaaatgc aaaacaattc ctgaaagaaa 1677901 ataaagatat catgctgatg atccaggagc aaattcgcga acattacggc ttggataata 1677961 acggagtagt gcagcagcaa gctgaagaga cacaagaaga actcgaattt gaagaataaa 1678021 aataaaataa gtttcaaatg atacaaaagg ctgagtgaaa aactcagctt ttttgtattt 1678081 tgcaaaaaaa tgataaaaat attgcttttt ttgacaactt ttttagggct ttattcgtct 1678141 aacaaaacgt gtgcaaaatg gaatttattt tgggaggaaa aaatgaatga caagcccaac 1678201 ccgcagaaga actgcgaaac gcagacggag aaaactaaat aaaagaggaa aactgttgtt 1678261 tggtctttta gcagtgatgg tttgcattac gatttggaat gctcttcatc gaaatagtga 1678321 agaaaacgaa ccatctcaag aaactgcagc ggtttcaaat accgatcaga aaaaagaggt 1678381 caaaaagaaa actgccaaaa aatcagagga acaaatcaaa acagtggatc gaaaccaaaa 1678441 aatcagcaat tatttaaaag agatcggttt cagcggaaca gccatgattg tcagaaatgg 1678501 agaaatcgta acaaataaag gttttggcta tgctgaccgt aaacactaca ttcaaaataa 1678561 tccattgaca tctttttatg tcggttcatc acaaaaagcg ctgattgcaa ctgctatttt 1678621 gcagcttgag gaaaagggga aacttcagac aagtgatccg gtaagcacgt atttacctca 1678681 ttttcccaac ggacaaacga ttactttgaa gaatctgctt acacatacat cggggataaa 1678741 cggacatatt gaaggaaacg gcgccattac tccggacgat ttaataaaag atatagaact 1678801 tcagggaatc aaacgtcagc cgggcgtatg ggactacaag gattccaact attctgttct 1678861 tgcttatatt attgctgaag taagcggtga gccctatgaa cagtacataa agaatcatat 1678921 ttttaaacct gcgggaatga cgcatgcagg cttttacaaa acatatgaaa aagaacctta 1678981 tcctgccgtc gggtataaga tggagggcag caaaacagtt acaccgtata tacctgattt 1679041 atcccagctg tatggagcgg gtgatattta tatgagcgct atagatatgt acaaatttga 1679101 ccaagcgctg atagacggaa aactgtattc gcaaaaaagc tatgaaaaga tgtttacgcc 1679161 agggagcagc tccacatacg gcatgggatt ttatgttgct cccggaagct attcaaacca 1679221 tggtgttatg ccgggcttca atatcttgaa cagctttagc aaatctgggc aaaccattgt 1679281 tattttgttc tcaaacattc aaaataatgc taaattgggc caagtgaaca ataaaatata 1679341 ccagcttcta aatcaagaat gattggcgat cttcttttgg atgaattgca ttcggcacgt 1679401 gaaaagaaga ctggcctgca aacgttaaga tggcaagctt gacaagtatt tccgacacat 1679461 ttacaatgaa gttgtaacat ttgttttttt aacatgattg ttaaaccatt taaacttgac 1679521 aagggcgatg aacacactca ttccctgtga aggttctgta tgttgagaaa actagacaat 1679581 gtacatgccg acacttttta agcaacaacc aagttcatag caagaggagg tgaaagtatg 1679641 accccaatta tgatggttct catctccatt ttgctgattc tactcggttt agttgttggc 1679701 tactttgttc gtaaaaccat tgccgaagcg aaaattgcgg gcgcacgcgg tgcagccgag 1679761 caaattcttg aagatgcgaa gcgtgatgct gaagcactga aaaaagaagc tctgcttgaa 1679821 gcaaaggatg aaatccacaa acttcgaata gatgctgaac aggaagttcg tgaaagacga 1679881 aatgagcttc aaaaacaaga aaaccgttta ctccaaaagg aggaaaacct tgatcgcaaa 1679941 catgagggaa ttgataaacg ggaagcgatg ttggagaaga aagatcattc tctgaatgaa 1680001 cgacaacaac atattgaaga gatggaaagc aaagtggatg agatgattcg tatgcagcag 1680061 tctgagttgg aacgaatttc gagtctgact cgtgacgaag cgaaacaaat cattcttgag 1680121 cgggttgaaa acgagctttc acatgacatc gccatcatga caaaagaaac tgaaaaccgt 1680181 gcgaaagaag aggcggataa gaaagcgaaa aacattcttt cactcgcctt acagcgctgc 1680241 gcagcggacc acgttgccga aacaacggta tcagttgtca atcttccaaa tgatgagatg 1680301 aaaggacgta tcatcggacg ggaagggcgt aacattcgta cgcttgaaac gctgacagga 1680361 attgacctga ttattgatga tacgcctgaa gctgtcattc tttccggatt tgatccgatc 1680421 agacgtgaga cagccagaat tgctcttgat aaactcgttc aggatggccg tattcatccg 1680481 gcacggattg aagaaatggt tgaaaaatct cgccgcgagg tcgatgacta tattcgtgag 1680541 atgggtgagc aaacgacatt tgaggttggc gttcatggcc tccacccaga tctcatcaag 1680601 atcctcggcc gcttaaagtt ccgtacaagc tacggtcaaa atgtgcttaa gcattccatg 1680661 gaagtcgcat tcttggccgg tctaatggca tcggagcttg gtgaagacgc aaagcttgct 1680721 aaacgtgcgg gtcttcttca cgacatcggg aaagcaattg accatgaagt agaaggaagc 1680781 cacgttgaga tcggggtaga gcttgcgacc aaatataaag agcacccagt cgtgattaac 1680841 agtattgcat cacaccacgg ggacgaggag ccgacttcca ttattgctgt actggtagct 1680901 gcagcagatg cgctttccgc tgcaagacct ggcgcaagaa gtgagacgct cgagaattat 1680961 attcgaagac ttgaaaaact tgaagaaatt tctgagtcct acgaaggtgt tgaaaaatca 1681021 tttgccattc aggctggacg cgaagtgcga attatggtga agccggattc aattaatgat 1681081 cttgaggctc atcgactggc gcgagatatc cgcaagcgaa ttgaggacga gctcgattat 1681141 ccaggtcata ttaaggtgac agtaatcaga gagactcgag ccgtagagta tgcaaaataa 1681201 agtgatgcgc taagcatcac tttatttttt tgacggcaag gaattttcaa gaagaaagga 1681261 tttacaaaat gagaatttta tttatcggag atgttgtcgg ttcaccgggc cgtgacatgg 1681321 tcaaagaata tgtaccaaag ctaaaaacaa aatataagcc tcactttacc attattaatg 1681381 gtgaaaacgc cgcacatgga aaaggcctga cggaaaaaat ttatcacagc ttaatccagt 1681441 ccggcgcaga tgcaatcaca atggggaacc acacatggga caaaaaagaa atatttgatt 1681501 ttatagatga cgttccgaac ttggttcgcc cggcaaactt tcctgaagga acaccgggga 1681561 aagggatcac atatgtgaaa gcaaacggca aagaactagc agtcattaat ttgcagggac 1681621 gtacgttttt gccgccgctt gatgacccgt ttttaaaagc ggatgaattg atcgcagaag 1681681 ctgcgaaaag aacaccgtac atttttattg actttcatgc cgaagcgaca agtgaaaagc 1681741 tcgcacttgg ctggtacacg gatggacggg catcggctgt agtaggaact catacacacg 1681801 tgcaaacagc ggataaccgc attttgccga agggaacggc atatattact gatgtgggaa 1681861 tgactggccc gtatgacggt atactgggga tggacagaga gacgattatt aagcgattca 1681921 aaacgaacct tccagtccgg tttactgtcg ctgaaggaaa aacaacgctc agcggagttg 1681981 tcattgacat tgacgatcaa acgaaaaaag ccgtgaaaat tgagcgtatt ttaatcaacg 1682041 atgatcacat gttctttgaa tagttgaaca tatggttatt ttataaaaat attaaaaaga 1682101 aaagcaggaa tatagcaact ccttagtgaa tatagtaaaa atggaaggta gcccgctatt 1682161 tttgaaaagc attgtgggga tggctttttg gatagcaaca tctaataatg attgttctaa 1682221 tgaacactca cttatccatt gtaaaactaa gggggagcag aaatggaaat cttaaaagtt 1682281 tcagcaaaat cgagtccaaa ttcagtggca ggtgcgcttg caggcgtgtt gagagagcga 1682341 ggagccgccg agattcaagc gatcggagcg ggtgcattaa accaggctgt aaaagctgtg 1682401 gcgattgcca ggggatttgt ggcgccaagc ggcgttgatt tgatttgtat tccggctttt 1682461 acagatattc aaatcgatgg ggaagaaaga acagcgatta aattaatcgt ggagcctcgc 1682521 taaaaacaaa taaagcattc tcaacctgtt tgcgtaatgc aaacaggttg tttttcattt 1682581 attgtgatat tttctcccga tagtattttt agcacataaa tgagcgaata tacaaaatca 1682641 gaaatgagct aaaacgtttc aaaaaaaatt tccgcccatt tttcaagaca gatacttttg 1682701 tccttctgga aaagacagtt ctgtttacgc ttattccata tcatggtaca atccgaatat 1682761 aacaagaatt tttcaaggag gattgtacat gcagagtgga aagatgaaag ctctaatgaa 1682821 aaaggacggg gcgttcggtg ctgtgctgac tgaagttccc attcctgaga ttgataaaca 1682881 tgaagtcctc ataaaagtga aagccgcttc catatgcggc acggatgtcc acatttataa 1682941 ttgggatcaa tgggcacgtc agagaatcaa aacaccctat gttttcggcc atgagttcag 1683001 cggcatcgta gagggcgtgg gagagaatgt cagcagtgta aaagtgggag agtatgtgtc 1683061 tgcggaaaca cacattgtct gtggtgaatg tgtcccttgc ctaacaggaa aatctcatgt 1683121 gtgtaccaat actgctataa tcggagtgga cacggcaggc tgttttgcgg agtatgtaaa 1683181 agttccagct gataacattt ggagaaatcc cgctgatatg gacccgtcga ttgcttccat 1683241 tcaagagcct ttaggaaatg cagttcatac cgtactcgag agccagcctg caggaggaac 1683301 gactgcagtc attggatgcg gaccgattgg tcttatggct gttgcggttg caaaagcagc 1683361 aggagcttct caggtgatag cgattgataa gaatgaatac aggctgaggc ttgcaaaaca 1683421 aatgggagcg acttgtactg tttctattga aaaagaagac ccgctcaaaa ttgtaagcgc 1683481 tttaacgagt ggagaaggag cagatcttgt ttgtgagatg tcgggccatc cctcagcgat 1683541 tgcccaaggt cttgcgatgg ctgcgaatgg cggaagattt catattctca gcttgccgga 1683601 acatccggtg acaattgatt tgacgaataa agtggtattt aaagggctta ccatccaagg 1683661 aatcacagga agaaaaatgt tttcaacatg gcgccaggtg tctcagttga tcagttcaaa 1683721 catgatcgat cttgcacctg ttattaccca tcagtttcca ttagaggagt ttgaaaaagg 1683781 tttcgaactg atgagaagcg ggcagtgcgg aaaagtaatt ttaattccat aaagggggat 1683841 aaacatgacg aaggaatttg agtttttaaa agcagagctt aatagtatga aagaaaacca 1683901 tacatggcaa gacataaaac agcttgaatc tatgcagggc ccatctgtca cagtgaatca 1683961 ccaaaaagtc attcagctat cttctaataa ttacctcgga ttcacttcac atcctagact 1684021 catcaacgcc gcacaggagg ccgttcagca gtatggagcc ggcaccggat cagtgagaac 1684081 gattgcgggt acatttacaa tgcatcaaga gcttgagaaa aagctggcag cctttaaaaa 1684141 aacggaggcg gcacttgtat tccaatcagg cttcacaaca aaccaaggcg tactttcaag 1684201 tattctatca aaagaggaca ttgtcatctc agatgaattg aaccatgcct ctattattga 1684261 cggaattcga ctgacaaagg cggataaaaa ggtgtatcag cacgtcaata tgagtgattt 1684321 agagcgggtg ctgagaaagt caatgaatta tcggatgcgt ctgattgtga cagacggcgt 1684381 attttccatg gatggcaaca tagctcctct gcctgatatt gtagagctcg ctgagaaata 1684441 tgacgcattt gtgatggtgg atgacgccca tgcatccgga gtacttggcg aaaacggcag 1684501 gggaacggtg aatcacttcg gtcttgacgg cagagtgcat attcaggtcg gaacattaag 1684561 caaggcaatc ggagtgctcg gcggctacgc tgcaggttca aaggtgctga tcgattattt 1684621 gcgccataaa ggccgtccat ttttattcag cacatctcat ccgccggcag tcactgcagc 1684681 ttgtatggaa gcgattgatg tcttgcttga agagccggag catatggagc gcttgtggga 1684741 gaatactgcc tattttaaag caatgcttgt gaaaatgggt ctgactctca cgaagagtga 1684801 aacgccgatt cttcctattt taataggtga tgaaggtgtg gcaaagcaat tttcagatca 1684861 gctcctttct cgcggtgttt ttgcccaaag tatcgttttc ccgactgtag caaagggaaa 1684921 agccagaatt cgcacgatta taacagcaga gcacaccaaa gatgaactgg atcaggcgct 1684981 tgatgtcatc gaaaagacgg caaaggagct ccagctattg taacaagagg aagagtttac 1685041 tcttcctctt ttgattcctt attgattatt attctcaatg agtgtacaat gataggttgc 1685101 cagttgtgca gagcttcaat aacctttata ctgaagggtg gaagtttggt ttgaaaggag 1685161 aaaatatgac atgaatgaaa aacaaaaatt agagagcgga caagttcatc catcggacaa 1685221 aaaatccgag aaggattaca gcaagtactt tgaagctgtt tacattccgc cttctttaaa 1685281 agacgcgaaa aaacgaggca aggaagccgt tacttatcat aatgacttta aaatttctga 1685341 acaatttaaa ggattgggag acggaagaaa gttctatatc cgtacgtacg gctgccaaat 1685401 gaatgaacac gatacagagg ttatggcagg gatctttatg gcgctcggtt acgaagcgac 1685461 aaactctgtt gacgatgcca atgtcatttt gttaaataca tgtgcaatcc gtgaaaatgc 1685521 tgaaaacaag gtgtttggtg agctcgggca cttaaaagca ctgaaaaaaa acaatcccga 1685581 tctgatttta ggcgtgtgcg gctgtatgtc ccaagaggaa tcagtcgtga accgtatttt 1685641 gaaaaaacat ccgtttgtcg atatgatttt cggaacgcat aacattcatc gcctgccgga 1685701 gcttttgtca gaagcatacc tttcaaaaga aatggttgta gaagtttggt ctaaggaagg 1685761 ggacgttatt gaaaaccttc caaaagtccg aaatggaaaa attaagggct gggtcaatat 1685821 catgtacggc tgtgacaaat tctgtacgta ttgcattgtg ccttacacac gcggaaaaga 1685881 aagaagccgc cgccctgagg atatcattca ggaagtgaga aggctcgcaa gtgaaggcta 1685941 taaggaaatt actctgttag gccaaaacgt aaacgcgtat ggaaaagact ttgaagatat 1686001 gacgtacgga cttggtgatt tgatggatga actgagaaaa atcgatatcc cgagaatccg 1686061 ttttacaacg agtcatccgc gcgactttga cgaccgcctc attgaagtgc tggcaaaagg 1686121 cggaaatctg cttgatcaca ttcatcttcc ggttcaatca ggaagctcag aagttctcaa 1686181 gctgatggcc cgcaaatatg acagagagcg ttacatggag ctggtgcgaa aaattaaaga 1686241 agcaatgcca aacgcttctt tgacaacgga cattatcgtc ggatttccaa atgaaacgga 1686301 cgaacagttt gaagaaacgc tttctctata ccgtgaagtg gagtttgaca gcgcctatac 1686361 gttcatttac tctccgcgtg aaggcactcc ggctgctaag atgaaagata atgtaccgat 1686421 gcgtgtgaaa aaagaacgcc tgcagcgtct aaacgcactg gtgaatgaaa tttctgctaa 1686481 aaaaatgaag gaatacgaag gcaaggttgt cgaagtatta gttgagggtg aaagcaaaaa 1686541 taaccctgat attcttgctg gctatactga aaaaagcaag cttgtcaatt tcaaagggcc 1686601 gaaggaagcc atcggcaaaa tcgtccgcgt gaaaatccag caagcgaaaa catggtcgct 1686661 tgacggagaa atggtaggag aagcaatcga ggtgaaatga gatgacgctc tactcaaaaa 1686721 aagacattgt gcagcaggct cgaaaccttg caaaaatgat ttctgaaaca gaagaggttg 1686781 attttttcaa acgggctgaa gcgcaaatca atgagaatga caaagtgtcc acaatcgtta 1686841 atcagattaa agccctgcaa aagcaggctg tcaatctgaa gcattatgaa aagcatgaag 1686901 cgctcaaaca agtagaagca aaaattgacg cgctgcaaga agagcttgaa gagattcctg 1686961 ttatccagga attcagagac tcgcaaatgg aagtaaatga cctactgcag ctcgttgcac 1687021 acaccatttc caaccaagtc acaaatgaaa tcatcacatc aaccggaggc gacctgctga 1687081 aaggggaaac cggttcaaag gtgaagcatt caaataacag ctgttctctc taaacacggt 1687141 gcctttacag gcccgtgttt ttttatcatt tgtgcggtta aaaatgaact aaataatcta 1687201 tgtaccaaat gttcaattgg tttttctgtg ctcagccgcg tataaacttt atcgcactta 1687261 taagtaaagt ttctaggcac ccctgcatac aatggaacag aaactttgta tttttatatt 1687321 ttatttataa aaatgcacac tagacaaatg cccagcataa gataacacga agaagaacaa 1687381 ggaggcatgc cggaatgtct gaatacaggg aaattattac gaaggcagta gtagcgaaag 1687441 gccgaaaatt cacccaatgc accaacacca tctcgcctga gaaaaaaccg agcagcattt 1687501 tgggtggttg gattattaac cacaagtatg acgctgaaaa aattggaaaa acggtagaaa 1687561 ttgaagggta ttatgatata aacgtatggt actcttacgc ggacaacaca aagacagagg 1687621 ttgtcacaga acgggtaaaa tatgtagatg tcattaaact cagatacaga gacaataatt 1687681 acttagatga tgagcatgaa gtgattgcca aagtgcttca gcagccaaac tgccttgaag 1687741 tgaccatttc gccgaatgga aataaaatcg ttgtgcaggc agaaagagaa tttttggcgg 1687801 aagtggtagg ggaaacaaag gtagttgttg aggtcaatcc tgactgggaa gaggatgacg 1687861 aggaagattg ggaagatgag cttgatgaag agcttgaaga catcaacccg gagtttttag 1687921 tgggagatcc tgaagaataa aaaagggact aggggagaca gtacccccaa gtctcttttt 1687981 tatattgata tatcattctt ttatcacttt ttgtttatgt tataatgaag gttggaaaat 1688041 agaaacgttg atacatagtg agggattaaa caatggccgg ttatacgcct atgatacagc 1688101 aatatttaaa aataaaggca gagcaccagg atgccttttt attttttcgc ctgggtgatt 1688161 tttatgaaat gttttttgag gacgccaaaa aagcgtcaca agagctggaa attacgttaa 1688221 cgagcagaga cggcggtgcg gctgaaaaaa taccgatgtg cggtgtgccg tatcattctg 1688281 cttccgcgta tatcgaacag cttattaaaa aaggatacaa agtggcgatc tgtgaacaga 1688341 cggaagatcc gaaagccgca aagggcgttg tgaaaagaga agtagttcag ctgattacgc 1688401 ccggaactgt aatggacggc aaaggcatcc atgagtcgga aaataatttt atcgcatctg 1688461 tttcagcctg ctcgaacgga tacggacttg ctctgtctga tttaacaacg ggagaaaatt 1688521 tggctgtttt gattgaacgg cttgaagacg tcatatcaga aatttattca gtcggcgcac 1688581 gggaaatcgt ggtttcagga agcttggatg ccgatacagt ggcacagctg agagagcggt 1688641 gcggtgcaac gatttcaatt gaagacggag aaacagacga acacgtaacg atcattgagc 1688701 acttaaataa tgaagatata acaaaaacat ttctgcgctt atatacgtat ttgaaaagaa 1688761 cccaaaagcg cagccttgat catcttcagc ccgtgcaggt gtatgagctt gaggaagcga 1688821 tgaaaattga cttgtactca aagcgtaatc tggagctgac cgaaacgatt cgttcgaaaa 1688881 ataaaaaagg ctcccttttg tggctgctgg atgaaacaaa aacggcaatg ggaggccggc 1688941 tacttaaaca gtggattgac cggccgctta tcagagtcaa tcaaatcgaa gagcgccaag 1689001 aaatggtgga aacattaatg tcccatttct ttgaacggga agatctgcgt gaacgtttaa 1689061 aagaagtata tgacttagaa cgccttgccg gccgcgttgc attcggaaat gtcaatgccc 1689121 gggatttgat tcagctgaag gaatcgttaa agcaagtgcc tggcatcaaa cagctggttg 1689181 cttcactggc tcatgacaag gccaaggaac gtgcaaagcg cattgaccct tgcggggatg 1689241 tacttgaact gctggaagaa gcgctgtacg aaaaccctcc tttatcggta aaagaaggga 1689301 acctgattaa agatggttat aatcaaaagc ttgatgaata tcgtgatgca agcagaaacg 1689361 gaaaagactg gattgcccgc ctggaacagc aggagcggga atacacaggc attcgctctt 1689421 taaaggtcgg ctttaataaa gttttcggtt attacattga agtgacaaaa gcaaacttgc 1689481 atttgcttga ggaagggcgt tatgagcgga agcagacgtt aaccaatgca gagcgctaca 1689541 ttacacctga attaaaagaa aaagaagcgc tcattttaga ggcggaaaat aacatctgtg 1689601 agctggagta cgagctgttt accgagctgc gcgagaaagt gaagcagtat attccgcggc 1689661 tgcagcagct tgcaaaacag atgagcgagc tggacgcact gcaatgcttt gcgacaatca 1689721 gtgaaaatcg ccactacacg aaaccagagt tctctaaaga tgaagtcgaa gtgattgaag 1689781 gcagacaccc ggttgttgaa aaagtcatgg acagccagga atatgtcccg aacaactgta 1689841 tgatgggcga taacagacaa atgcttctca ttacaggtcc aaacatgtca gggaaaagca 1689901 cgtatatgag acaaatcgcg ctcatttcca ttatggcgca aatcggctgc tttgtacccg 1689961 cgaaaaaagc ggtgctcccg attttcgatc aaatttttac gcgaatcggc gctgcagatg 1690021 atttgatttc cggacaaagt acatttatgg tagaaatgct tgaagcgaaa aatgcgattg 1690081 tcaatgcgac gaaaaacagc ctcattctgt ttgatgaaat cgggcgggga acgtccactt 1690141 atgacggcat ggcgctggca caggcgatta ttgaatatgt tcacgatcat atcggcgcca 1690201 agacgctgtt cagcacacac tatcacgagc tgaccgttct tgaggacaag ctgccccagc 1690261 tgaaaaacgt tcatgttcgc gctgaagaat ataacggaac ggttgtcttt cttcatcaaa 1690321 ttaaagaagg tgcggctgat aaaagctatg gtatccatgt agctcagctt gccgaactgc 1690381 cgggagatct gattgcgcgc gctcaagata ttttaaaaga gcttgagcat tcaggaaaca 1690441 aaccggaagt gccggtgcag aaacctcagg tgaaagaaga gccggcacag ctgtcctttt 1690501 ttgacgaagc ggaaaagccg gctgaaacac caaagctttc aaaaaaagaa aagcaagtga 1690561 tcgatgcttt caaatcactt aatatactgg atatgacacc gcttgaagcg atgaatgaaa 1690621 tgtacaagct gcaaaagaaa ttacattaaa acggggtgat gaatgtggca aaagtcatcc 1690681 aactgtcaga tgagctttca aataaaatag cggcgggcga ggttgtggaa cggcccgcct 1690741 cagtcgtcaa agaattggtg gaaaatgcga tcgacgctga cagcacagtc attgaaatcg 1690801 atattgagga agcaggcctt gcatccattc gggtcttgga taacggcgaa ggaatggaga 1690861 atgaagattg caagcgagct ttccggcgcc acgcaacgag taaaataaaa gatgaaaatg 1690921 atttattcag ggtgagaacg ctcggtttca ggggagaagc cctgccgagt atcgcgtcag 1690981 tctctcatct ggagattaca acaagcactg gtgaaggagc tgggacgaag ctcgtcctcc 1691041 aaggaggaaa catcatttcc gaatcgcgtt cctcaagcag gaagggaact gaaattgtcg 1691101 tttccaacct gttttttaac acaccggccc gtttgaaata tatgaaaacc gttcatacag 1691161 agcttggaaa cattacagat gtggttaacc gtattgctct ggcgcatcca gaggtatcga 1691221 tccgcctgcg ccatcatggg aaaaacctgc ttcaaacgaa cggaaacgga gatgtgcgcc 1691281 atgtactggc agcgatttac ggcacggctg tcgccaaaaa aatgcttccg ctgcatgtga 1691341 gctccttgga ttttgaagta aagggatata tcgccctccc agagattaca cgggcgtcga 1691401 gaaactatat gtcgtctgtg gtcaatggcc gttacattaa aaatttcccg ctcgtcaaag 1691461 cggttcatga aggctatcat acgcttctgc cgatcggacg ccatccgatt acttttatag 1691521 aaattacgat ggacccgatt ttagtcgatg tcaacgtgca tccatcgaag cttgaggtcc 1691581 ggctcagcaa ggaaacagag cttcatgact taatacgtga cggaattaaa gatgtgttta 1691641 aacagcagca gctgattcct agtgcccagg tcccgaaaaa atcagcacct gccatcaaaa 1691701 atgagcagca gtttataacc tttgatgaaa agcctccgga aaaaaaagtt ccggaaaaat 1691761 cgactgcgcc atcttattca ccgatgaagc tcagctcagt cgtaaaagag ccggttgatg 1691821 cggaggaaaa attgccccct ctccaatttg atgctcctcc tatcgttgat caggaacaaa 1691881 cccttgaggt gtccgatgtt tcagcagaac agcctgaaac atttgagcag gaatgccatg 1691941 aggaacagcc gcagccagcg tctgatcggg ttccaattat gtacccgatt ggccagatgc 1692001 acgggactta tatattggca caaaacgaaa acggcctata tattatcgac cagcacgccg 1692061 cccaagaacg tattaaatat gagtacttcc gtgaaaaggt gggggaggtt gagcctgagg 1692121 tgcaggagat gattgtaccg ctgacgttcc actactccac aaatgaggct ttgattattg 1692181 aacagcacaa acaagagctc gaaagcgtcg gtgtcttttt agagtcattc ggctctaaca 1692241 gttacatcgt ccgctgccac ccagcctggt ttccaaaggg agaagaagca gagcttatag 1692301 aagaaatcat tcagcaggtg ctcgactcca aaaatataga tattaaaaaa cttcgcgagg 1692361 aagcggcgat tatgatgagc tgcaaaggct ccatcaaagc aaatcgccac ctcagaaacg 1692421 acgaaatcaa agcgcttctg gacgacctcc gaagcacatc agacccattt acatgcccgc 1692481 acggccgccc gatcatcatt caccactcga catatgagat ggaaaagatg ttcaaacgcg 1692541 tgatgtagcg ggggtggtag gcattgatcc attctctgaa tggatcaatg ctttttttgt 1692601 actccttcga gtgtcagatt ataagaaacg gttgtaaacg tgtgagcagt gttaacgcat 1692661 tatacttcat ggttcctccg tataacaaaa tttccattta caggcaattg ggattaatgt 1692721 atattttggg tgagggggtg gaaacatatg gcatgtggtc cgaagatcat tatctttttg 1692781 gatgaacttg atgatccaaa tgtgagaatc attttagaat gcagaattta aattacaaca 1692841 ttgtgttttg ctccctgttc gtgtgaacag ggagattttt tcgtttatat aactggtgat 1692901 gtccaaatat agggtgttat gaattttcca tatctgccat cggctttaag ctgcttctct 1692961 attaggctgg ttatcaaaag caagttcaat gatagccatg aaagctgata tcacaacaag 1693021 caagacatct ggaatataaa tagactgcat aaagtaatct gcaaaacaga tcgttataag 1693081 attgctgata aaatacagta taaaagcaaa aagtgcagtc tttttcaatg aaagtgattt 1693141 tgccaaaatg atagagataa tctttgtgag tgggtctatg attaaaccta cagcaaagca 1693201 ggctaaaata aataaagcta atgtttgatt ggaagcgtat gtgatgccaa gtatggagaa 1693261 taagcctttc atcccgaaga aaaagccgcc gaagatgact gcaagcgcga tggccgcgat 1693321 aaaagtaata gatacaattc cgattaattt tgatctcagg ttaaaatctt tagagtgctc 1693381 gttctgttct ttttggttca tgtatgacac tcccttcacc tgcttactca tacaaacagc 1693441 acccttgaat cagcccaaaa tatctataag tctgttttct gacgaaaata gtatagcata 1693501 ttttaacaaa accaaaaaag gccctttcca ctggggaagg gcctttttca tcatgttaac 1693561 tcctgagatt cgccgaagct ttctcttttt ttggccaaat aaaatagctg gctgtaatga 1693621 gaaagtcaat gcctataatg acagtccaca gtttaagaat gccgctcaac gcctcggttc 1693681 gggaagagtc attgataaaa tagatcatcc ctgccaatag tcccgcacca attaagtagg 1693741 ccagcacatg tcttagccag cctttcgcac cgtgcttggc atggtccatt ccaaaacgtt 1693801 tcagcggttt tgttcctttt tttgtcacat aatattgaaa cttttcatct gcccattgaa 1693861 tcatttgttt cccataagcg atcgatatac cgatgtaaac agctgcaatc ccatgggctg 1693921 cggtcgctga ggctccgcgg taaaggtcca caccagttgc cgctaacaag atcaaatcga 1693981 taactggagt taaggcaagg aatagcagtc ctaatgtatg tcgtttgaat acgtagcgta 1694041 cagcaagccc caaaacaatg acaacccaaa acgcaatttc acagaaaaca atcatccatg 1694101 cgataccgtt caatccattc ccctcttttc aatacagttg tattatttaa ataatatgtt 1694161 accatctttg tttttgtaac acaactgtat tataaaaatt gccctctcat ttttttcttg 1694221 ttacaataaa gctatgccaa aacaaattga ccatgagaaa agaagaaaac aaattgcaga 1694281 agcaacgtgg cgcgtcattt tagaacgagg gatggaggga gcatcagcca gaaatattgc 1694341 aaaggaagct ggattgtcat tagaagcttg atcggcaata gttaccctta ttatcaagat 1694401 aagaaagaaa aggatttttc gctacgctca aatcctttaa aaaaacacaa aagaccacat 1694461 tttttaatgt ggtcttttat tcttcaacta aagcacccat tagttcaaca aacgaaaatt 1694521 ggataaagtg ggatattttt aaaatatata tttatgttac agtaatattg acttttaaaa 1694581 aaggattgat tctaatgaag aaagcagaca agtaagcctc ctaaattcac tttagataaa 1694641 aatttaggag gcatatcaaa tgaactttaa taaaattgat ttagacaatt ggaagagaaa 1694701 agagatattt aatcattatt tgaaccaaca aacgactttt agtataacca cagaaattga 1694761 tattagtgtt ttataccgaa acataaaaca agaaggatat aaattttacc ctgcatttat 1694821 tttcttagtg acaagggtga taaactcaaa tacagctttt agaactggtt acaatagcga 1694881 cggagagtta ggttattggg ataagttaga gccactttat acaatttttg atggtgtatc 1694941 taaaacattc tctggtattt ggactcctgt aaagaatgac ttcaaagagt tttatgattt 1695001 atacctttct gatgtagaga aatataatgg ttcggggaaa ttgtttccca aaacacctat 1695061 acctgaaaat gctttttctc tttctattat tccatggact tcatttactg ggtttaactt 1695121 aaatatcaat aataatagta attaccttct acccattatt acagcaggaa aattcattaa 1695181 taaaggtaat tcaatatatt taccgctatc tttacaggta catcattctg tttgtgatgg 1695241 ttatcatgca ggattgttta tgaactctat tcaggaattg tcagataggc ctaatgactg 1695301 gcttttataa tatgagataa tgccgactgt actttttaca gtcggttttc taatgtcact 1695361 aacctgcccc gttagttgaa gaaggttttt atattacagc tccagatcat cgaattcctg 1695421 tctgagttga ttgacttggc aaaagaacga gggctaaaca aaccagataa acaaatacgt 1695481 gcgcaggctc agcaaatgat gaaaacacag cgcgcctatg atttggagtc gtacactgtt 1695541 aagcctctcc ctgatcctga gacggtaaaa tgttattatt tccgcaacaa aagcaggtct 1695601 ttctttggtg atttagacac ttatttcact ttatcaaatg aaaaagaacc gtttgatcaa 1695661 gctgcctatt gggaggaatg ggagcggcaa attcctcatt tccacctggt ggatgtcgat 1695721 tcaagcaacc acttcatgat attaaccgaa ccgaaagcgt caacagccct gttagaattt 1695781 tgcgaaaagc tctattcaaa caggggagta gtgaatgcga atttccttaa ggctttccgg 1695841 aagaaacatg aagcgaggga agaaaaagaa acagatgaat tggtgaagcg ctgagaaaac 1695901 acaaacgccc cctcttttaa aagggggcgt tttgaatgtt attttgaaag tgaaacaggg 1695961 agactttcta atcctcttaa aaagacattt tttctccatt gaatgtcatc aggtgcaacc 1696021 gcaagttcaa tatcaggaaa tctcttcaaa agtgctttaa atgcaatgtg gccttccagc 1696081 ctggcaagag gcgctcctaa gcagaaatga atgccaaaac caaaagaaat atgtctatta 1696141 ggcgaccgat ttatatttaa tatttcgggg ttctcaaaaa aattcgggtc gcgattggca 1696201 gatccgatgc ctataaaaat catgtctcct cttttgatcg aatgcccctt atatgtaaag 1696261 tcttcgatgg cccaccgatt tgccatcata acgacaggtg aggtgtatcg cagcaattct 1696321 tcaaccgctg tagcgatcat ttcaggctgc tgcttgagct tctcacattc cttcttgtgc 1696381 tgcagcaatg cgagggtgcc tgagccgagt aagttaacag ttgtttcaag gccggctaca 1696441 acgagcaaga acagcatcga atagagctct ttttcgctta acttgctgcc gttttcctca 1696501 gcatgcacaa gtttgctgat taaatcgtct tttggcttta ttcttctgtc atggatcagc 1696561 ttagcgatat aatctttaaa ttcacgaagg gcctgatttg tcagctctct attaccttca 1696621 gaggtatcaa ccatcgcatt ggtccagatt tgaaactgtg accgatcttc ttttgggatt 1696681 cccatcaatt cagatataac aataaaaggc aaaggggaag cgaaggattt catgatatcc 1696741 gctttatttt ctttttccat ttcatctaaa agctgttcag caatttgttc aatgctgccg 1696801 cgcagatttt caatggttcg gggagtaaat gcttgatgaa caagtgatct caggcgggta 1696861 tggtcaggtg tgtcttttgc cagcatatga tcggatacaa aatcgatatc ttcactaacg 1696921 ttgagcattt tgatttgttc ttggttcatc acatttttta cgtctcttgt aattcgattg 1696981 tcttttaaaa aggccataca atcatcgtat cgggtaatta accaggccgg atatgtggct 1697041 ccgaaccgtt ttaattcaaa tcggtgaatg ggctcttcct ctctaaatcg tcctaaaact 1697101 gaaaaaggat tgtgatgaaa ctctttacca tgcggatgaa acatcaattt ttccatttgc 1697161 attctcctcg cctaataggg taaatagatg aatcaaattg ctgaattagt ttacaaaaaa 1697221 cagaatgatt tgaaatgtaa tcctgtctct aaaactatat atctatctta ggcgtcattc 1697281 aatagggaga agaacgaaaa aagtgaaaaa acggctcgat ataaagcagc gcctttgaac 1697341 gaaagctcaa aggcgctacg ctgtattatt ttgatgaaag tggctgtcag ctgtgctgga 1697401 tatcaattgt atatactgca cgatctgtta cgaccttcaa tccttcgttt tcttggtgaa 1697461 tatgaagctc acctaataaa ggaatctcat aggcattttg cggaagcggt acgtttccgt 1697521 cctcagtgaa tgttgttcct tcgccttcta aaacaagctc ttctttcgca acataatcat 1697581 caggatgatt cgtactgcgt atagccactt tttgaaggtg gagaacaatc tgatccaagt 1697641 ctgatatctc ttcatcatgg gtcaattcac cttttctaat atcaagcgtc tggccgactt 1697701 ttgattccag ccattgagaa agctgtgtat tcgtgtgtgc catcaatatt cctccttttg 1697761 atctacacga tactattccc aattgctgca tcttttacac gggaaagagc cgccccactc 1697821 tttatgtatg aaacagttcg ctgttgagtg ccttgatata gcgtacggca gaacgctgga 1697881 ccgattcgtc ggcattttct ttgacaactt tagagaaagc attgtaaagc cggttgaatt 1697941 gaagcggttt tactttggct gctatttctt caactttgga ggcgggaagg ggaatgagat 1698001 ttgggtagct gtacataaag ctgacccagt ttcgatccgc cgcaaccgta atgatatctc 1698061 cggtcaatag acagcctttc ccttcattgc ccttgctcca atgcaaaaca gcaccgcctt 1698121 taaaatgtcc gcccagtcgg taaaggtcca gtcccggctt catattgagc gtttcccctg 1698181 accagaagtg aatgtgattg cttggccttg tcacccattc tttatcatcc tcatggatat 1698241 agatcggcgc ctgaaacgct tcagcccact caacctgagt agagtaataa tgtggatgag 1698301 acaaggcgat ggcttgaata ccgcctaatt cgttgatttg gtcaattgtc ttttggtcaa 1698361 gatatgtcat gcaatcccac agcacattga agcccttatg ctgaataaga tgggctgttt 1698421 gtccaatcgc aaactctggt tcagttttga tgctgtaaag atgctcttct tcctttttaa 1698481 ggatgttttg aaggtttcct ttctcacgca tgtcttcaag ggttgtccaa gtttgtccat 1698541 cgggatgaat atactgtctt tcatcctcgc aaatcagaca cgagttgggc ggatctacag 1698601 tctgtgcatg ttgcacaccg catgtattgc agatataata tggcactttc ttcacttcct 1698661 tcatctattt tccattattt taccttatga ttatgaatat tcaaacgaaa aaaccggcag 1698721 ttctgctgag agagaattgc cggcttttga tgatgtttat tggccgggaa cggaattttc 1698781 tgcgttgaca gcgcccgctc cgtagatatt cggatcttca tctttccatt tgtccgtgcc 1698841 gtttttcaaa agctctttta cttcatcagg ggtaagatcc gggttttgct gaagaattaa 1698901 agctgcgatt cctgcgcaaa tcggtgttgc catcgaggtt cctgacattg taaagtactg 1698961 agaccctaca cggcttgact tttggagctt atcaatataa gaattcggag agcgaaggga 1699021 aataatatta acacccggcg ctaaaatatc gggcttttct ttcccgtata ctgtcgggcc 1699081 gcggcttgag aaggaagcga cagtatcatc atcgctgctt gcagtattgt tatcgtcaag 1699141 cgcacctact gtaatcacct tttcgctcac gcccgggctt gcaatggtct gcgaatcagg 1699201 gcctgagttt ccggcagcga cacagacgac aatccctgcg ctccacgctt cctcaaccgc 1699261 tctgactaac ggatcttcct gttcatgatc atatctaagg gcatcgcccc cgagcgacat 1699321 gctcataata tcaatcggtt catcggggtt gtcctcattg tattgaatac accactcaac 1699381 accctctata atatctgcta acgttcctga accctgcttg tttaatacct ttacgccgat 1699441 gagattggct tccggtgcag gtccgcggta ttgaccggaa gaggatgcac cgctgcttgc 1699501 gacatcacct gcacagtgtg tgccatgacc attatcatcg tacggctctg ttttttgatt 1699561 gaccatgtcc gcgaatccga taattcttcc ttctagatca ggatgcgggt agattcctgt 1699621 atcgacaaca gcgacagtaa caccttttcc tgtcagggtt tgcccgtttc tgacgacttc 1699681 cttcgcatgg cttgcttcgg ttgccgtgtc taaaagcgct ttgacttcgc ggtttaaata 1699741 cactttacgg atattgctgc attcagagag aagggaatgt aatgctgaag gagtaacctc 1699801 ggcgctgcag cagttgattt tgttgaagcg gctttttagc ttgctgcgtt tttctttttg 1699861 cagcacctct ccagccattt gaaagccggt ctcgtgacag ccttcctcaa attcgataat 1699921 gactgacatt ttttttctgt tttgcaattt ggtttcgaaa aatttatgca agaagcaagg 1699981 agtccatttg aagggcttgt aaagttgcaa tacggtttcc cgtaacggcc aatctagctt 1700041 gtgagcattt gctctcacca tttgtaccat agagtaccca aacatgtatt ttcctcctat 1700101 tataaggttc tctgtatact ctatgaacag atgataggtt tggtaagttt gtttgtcctc 1700161 tgtaagagac agacaagagt ttgtttttct gaatctttcg cattagatac gatagattca 1700221 gaagctgagg aaatcattgg ggattgaaaa agaacgtttg ttcgtattat aatgtgatca 1700281 tatcaaactg ggaaggggag agcaaccgta tgaatttcta cttgcaccga tctttggaaa 1700341 gccaaatgcc aatcagcatt atatatgaag aaagacggaa cgattagtaa aagaacgatt 1700401 attgtgagac agaaaagcaa aacgaaaatc aaagcatttt gtttttcgaa acaacagatc 1700461 agaacatttt tattggactc tatcctctcc tgtgattttg tgagaacaaa taagcaaaat 1700521 ctctattctg caggccggta acagctgtcc gtctcagcaa ccgggcagcc tgttactaaa 1700581 accctcctta aacctatata catttatttg ccaagtgagg ttgttcctac cttttttgtc 1700641 tttcctctca accttttttc actcttattt gaaatgaacc gctaataacc gtgacaatca 1700701 attgattttt tgaaaccggg aactttttca ctgatgatat tgtgtataca atggtaagat 1700761 aaaacctatt ggctaaacct catataatga accgcgccat tcttatgaaa ggagttaaac 1700821 atgagaagat ttttactaaa tgtcatatta gtcttagcca ttgtcttgtt cttgagatat 1700881 gttcattact cattggaacc agaaccatca aatcagccag atacatattc aaatttcagc 1700941 agcttggcag agaatgagag cccagccgat tacgatattt catataatga gaaaaaagga 1701001 agcaaagtct taattatgtc tccgcatggc ggaagaattg aaggcggagt aagtgagctt 1701061 gtgcgttatt tcaataatga atactctaca tacctatttg aagggttgaa gtcccatgat 1701121 aaccaaacac tgcacattac aagcaccaac tttgatgagc cattggcaaa aaagaaaatc 1701181 aaggagcatc aatatgtggt ggcttttcac ggatataaag gagagaacaa gaataccctt 1701241 gtagggggaa cagaccgaaa gcgggcgaaa atgattgtga gagcccttga gcggagaggg 1701301 ttttccgctg agttagcgtc gtctaaaagc ggtcttgctg gattgaatgc cgaaaacatt 1701361 aataaccaag gggaaacggg gctaagtatc cagctggaaa tcagccgtga gcagagagaa 1701421 gcattttttg atgattttta ttataaaaat agaaaataca caaagaacag tgaattttat 1701481 gcttatgtca gtgcgatcaa aggtgtcctg gaaaaagagt attcgtaaca agcagatcag 1701541 aagacaaaat aagagaagat cagtagactg aaataggata aaaaaggagg caaaacaatg 1701601 gcagatcatc atttttattt aaaagcgaac tggccgggta accgtaatga tgtcggtacg 1701661 atcgaaagcg gaaacctgat cacatcgatt tccattccta aagaaatgga tggcccggga 1701721 gaagggacca acccagatga aatgcttctc ggggcggcag cgacctgtta cattattaca 1701781 cttgcagcga tgatggagag aagcgggctg gaaaaagaag acttacagat ggagtcagaa 1701841 ggcattgtca acgttacaaa aggagtcttt acatacaaaa agatcattca ccgtccctct 1701901 gtcgtgctta aacatgatgc ttcacaagac gacgtcgcat tggcgcacaa actttgtaaa 1701961 aaagcggagt cgtcatgcat gatttcgcgt gcaattcaag gaaatgtcga gctgcagctt 1702021 gaagcctctg tgaaactggg tggagaataa agaaaacaga cggtcactca caggccgtct 1702081 gttttttatc ttcagcgtgg gctttcgatt gatttagcac gaccacgcct gcaatgacaa 1702141 gcgtgagacc gaatacacct tttaaactga tggtttcgcc aaaaagcaaa aacccgacaa 1702201 ttgctgtaag cgcggtacca acgcccgacc atgttgcata cgcgcttgat aagtcaattg 1702261 tttttaaaga aaagcttaga aacgtaaaag cagaaagaaa tccgactatg actccggcaa 1702321 tgggccaggc ttgtgtaaat ccttctgaaa gcttcaacat cgtgctccca aacacttcag 1702381 atacaatggc gagagccaaa taaagcaatc ctctcatctt catcactcct ttacggccaa 1702441 ttaagtaaca cgacccctga tagtaataaa agaatcccga taagcccttt ggcattcaga 1702501 tcttccttga accattttac tccgatcact gtcgtcagca ccgtgcctgc cccgctccaa 1702561 gtcgcatagg agaggctcag gggaatatgg tttaaagtca gggacagcat ataaaaggcg 1702621 agggaatagc caataacgac caaagcactt ggcttccact ttttgaagcc atcagatact 1702681 ttcagcatgg ctgctcctat cgattccgaa catatggcaa tcgtgaggaa tatatatcct 1702741 atcaacatca tgaattctcc tcactatatt tttagattag aaaaaaaact tcagctagaa 1702801 aaatattagt gtatgcctat gtatgagtca agagattcat tttcacacac ttaaaaagac 1702861 ccctttttaa ggggtctttt gcgtttaata ataaaaaggg aacggggcat acggataata 1702921 ggggtatccg ccatacaaat aaggattaaa taaagcgctt cctataagcc cgcctgcaag 1702981 gccgccgata aacggtcctc caaaaaatcc gaatggccgg ccaaacccat aaccaaatcc 1703041 gggtcttcca aacccgtaac cgaacccgaa cggtcttcca aacccaaatg gtctcccgaa 1703101 tccgaacggc cttccaaata ttcttgtatc ttcagggctg aaatgctcta actcgttcat 1703161 gttttctttc ctcctgtaat aaagtgtaga tgatgcagtg tattcaccct gcccggattt 1703221 gattgggcga atcgaggaaa aggaggatgt gaacacattg ggcctgtatc agtctgactg 1703281 gtcaaaagca ccgccccacg cacatgctta tcatgtcaaa acaacgagag aacagggcca 1703341 ttatcatctc atcgaagggt ttactcagcc ggcaaacgga tcaaataccg atcagcatac 1703401 acattactat acagggatca cttcatttga aaacggccat tttcatcggt attacggaat 1703461 ctcaggaccg gcgattccct tagcagatgg cacacattat catgaaatcg aagaaacgac 1703521 gtatctggcc tataacgagc cgattgagat ccagtacgga ggggttgtgt acgatcccgg 1703581 agatgacaga agaaaaacgc atcgtcatac cctgaaagga aagacaaggg aaattgtcgg 1703641 caatgagccg ctcggctggt agaaggatgt ttaccgatgc aaaaaaaggg caaaatggat 1703701 aggtggttgt ccatgttgaa tgctataatg gggggagatt tataaaagag agtgatacat 1703761 attgaataat acgaagcagc ccgttgtcat tttagtcgga ccgacggcag tggggaaaac 1703821 caatttaagt attcagctag ccaaatcctt aaacgcggaa attatcagcg gagattcgat 1703881 gcagatttat aaagggatgg atattggaac agctaaaatt accgaacagg agatggaggg 1703941 agtgccccat catctgattg acattttaga tccccaagac tctttctcta ctgccgatta 1704001 tcaaagctta gtaagaaata aaatcagcga gattgcaaat agaggaaagc ttccgatgat 1704061 tgtcggcggt acagggcttt atatacaatc tgtgctttac gattatacat ttacggaaga 1704121 ggcaaatgat cccgtgtttc gagagagcat gcaaatggct gctgagcggg aaggcgctga 1704181 ctttcttcat gccaaacttg ctgcagcaga tcccgaggca gcagctgcga ttcatccgaa 1704241 taatacaaga agagtcattc gcgcactgga aattttacat acgtccggaa aaacgatgtc 1704301 ccagcatttg aaggaacaaa aacgagaact tctgtacaat gcagtgttaa ttggcctgac 1704361 aatggataga gacacgcttt acgaaagaat taatcagcgg gtcgatttga tgatgcagtc 1704421 aggccttctt ccggaagtga aacgcttata cgacaagaac gtgagagact gtcaatcaat 1704481 acaggcgata ggctataaag agctgtatgc atattttgac ggttttgtga cactttccga 1704541 tgctgtcgaa cagctaaagc agaactcgag gcggtatgcg aaacgccagc tgacgtggtt 1704601 tcgcaacaaa atgcaggtca catggttcga tatgacaccg cctgttgata tggagctgaa 1704661 aaaaaaggaa attttcacac atatagcagg aaaactcgaa ctttaatcga aactgtatga 1704721 tatagagaat caaggaggac gaaacatgaa accgattaat attcaggatc agtttttgaa 1704781 tcaaatccgg aaagaaaata cgtatgtcac tgtttttttg ctgaacggct ttcagttgcg 1704841 gggccaggtg aaaggctttg ataactttac cgtattgttg gaatcggaag gtaagcagca 1704901 gcttatatat aaacatgcga tctcaacgtt tgcgccgcaa aaaaacgtcc agcttgaact 1704961 cgaatagatc aaaaaatgcc atgtcaagac atgaggaaag gctgtcgggg gttcccggcg 1705021 gccattttta acatgaatcc acttttgctc caagcttttt gtgtaagctg accatgccaa 1705081 ggcacggtct ttttttatga gaacaacata cggaagtaaa aatggtatat tatgtataaa 1705141 atgaatttgg gagtgatcga tcttgtttga aagtgaagca gaactgagac gaatcaggat 1705201 tgcacttgta tggatagctg tctttttact gttcggggcg tgcgggaatc aagataccat 1705261 tattgaaaca gacaacggca attcagacta tgaaacgcct cagcccacct cgtttccact 1705321 tgaacataac cattttggcg ttatggagga cggctatatc aaaatttatg agtataatga 1705381 gtcccgcaat gaggtaaagc tgaagaaaga atacgcggat gatgagcttg aataaaattc 1705441 acaagcattc gaatttacaa agcggatgcc agccgctaaa ctaaatacag acacagatca 1705501 aacagagggt gaaaacatga agcataaagt gatcgtgaat cattgggaag aaatttgcga 1705561 agatgattct tgctatgaat acggaacaag tatcattgtg aacggaaaag aattaatcag 1705621 agaagcgtca attatcactg ctttgaaggc ggttttagaa gagatcggcg cggatgttga 1705681 aatagaagaa acagtagaga gcgaaaaatg ctgtgatagc ttaagaaaaa aaaatctaga 1705741 ctactaagca gttttttttc atgttatgat atacatcggc taaaaacgac accccgagta 1705801 ggacgagaga tgattctcgt tctgctctct tttttgggcc ctaatgagtc tgcccgtttg 1705861 cctgatttga tcaaaatatg aatttttcat aaaaacgaat ctatatattg tgtttttgct 1705921 agagggtagt atactatata tagtgttagt gatgagagat tcatattttt tgataggtcg 1705981 tgataaaacg tggtacaaat catatttgat tcgaaaacag ggaatgttca gcggtttgtg 1706041 aataaaacag gctttcagca gatacgcaag gtggacgaaa tggaccacgt ggacactccg 1706101 tttgttttgg tcacctacac gacaaacttc ggccaggtac cggcatcaac acaatcattt 1706161 ctcgaaaaat acgcccatct cttattggga gtcgctgcga gcggcaacaa agtatggggc 1706221 gataactttg caaaaagcgc cgataccatt tcaagacaat atcaggtgcc gatcttgcac 1706281 aaatttgaac tcagcggcac atctaaagac gttgaattgt ttactcagga ggtagaaaga 1706341 gttgtcacaa aatcaagtgc caaaatggat ccagttaaat aacgaaatca tgatccaaaa 1706401 agatgggaaa ttccagtttg ataaggataa agaagctgta catagctatt ttgtagatta 1706461 tatcaatcaa aacacagtct tctttcacaa tttaaaagag aagctggatt atttggttga 1706521 aaaccaatac tacgaagagg aattcttaag cctttattct tttgaagaca ttaaagaagt 1706581 gtttaagaca gcttacgcta agaagtttcg ttttccttcc ttcatgagtg cgtttaaatt 1706641 ctataatgac tatgctttga aaacgaatga caagaaaaaa atcctcgagc gttatgagga 1706701 ccggatctca attgttgcgc tgttcttcgc taacggcgac actgagaaag caaaagaata 1706761 tgtaaacctg atgatcaatc aagaatatca gccgagcaca ccgacatttt tgaatgccgg 1706821 cagaaaacgc cgcggtgaac ttgtgagctg cttcttgctc gaagttaatg attctttaaa 1706881 tgacatttca agagcaatcg atatctccat gcagctttct aagcttggtg gcggggtttc 1706941 tcttaacctg tccaagcttc gcgcgaaagg tgaagccatt aaagatgttg agaatgcgac 1707001 aaaaggcgtt gtaggcgtca tgaagcttct tgataacgcg ttccgttacg ctgaccaaat 1707061 gggacaaaga caaggctccg gcgcggcgta tttaaacatt ttccaccgcg atatcaatga 1707121 ttttcttgat acgaaaaaga tttctgcgga tgaagatgtg cgtgtcaaaa cgctttcgat 1707181 cggtgttgtc attccggata agttcgttga gcttgcacgc gaggacaaag cggcttatgt 1707241 attctacccg cacacgattt ataaagagta cggccagcac atggatgaga tggacatgaa 1707301 cgaaatgtac gacaagtttg tcgacaaccc tcgggtgaaa aaggaaaaaa tcaacccgcg 1707361 gaaactgctt gaaaaattgg cgatgcttcg ttctgaatca ggctatccat acatcatgtt 1707421 ccaagataac gtcaataaag tgcatgcgaa taaccatatt tccaaggtca aattttctaa 1707481 cctttgctct gaagtgctgc aggcatctca agtttcttca tacacagact atgatgaaga 1707541 agatgaaatc ggtctggata tttcctgcaa cctgggttcg cttaacattc tcaatgtcat 1707601 ggagcataaa tcaatcgaaa agacagtcaa gcttgcgaca gactctttaa cacacgtgtc 1707661 tgaaacaaca gacatccgta atgcgcctgc tgtaagacgg gcaaacaaag cgatgaaatc 1707721 aatcggcctc ggtgctatga accttcacgg ctaccttgcg caaaacggca ttgcgtatga 1707781 aagtccggaa gcgcgtgact ttgcaaacac gttctttatg atggtgaatt tctactccat 1707841 ccagcgttct gcggaaatcg caaaagagaa gggcgaaacg tttgatcaat atgaaggatc 1707901 aacctatgcg acaggtgaat acttcgacaa atacgtttca actgatttct caccgaaata 1707961 cgaaaaaatc gctaatctgt ttgaaggtat gcatatcccg acgacagagg actggaaaaa 1708021 gctaaaagca tttgtcgctg aacacggtat gtatcacagc tacagattat gcattgcgcc 1708081 gacaggctct atctcatacg ttcaatcaag cacggcgtct gttatgccga ttatggaacg 1708141 gattgaagaa cgaacatacg gcaactcaaa aacgtactac ccaatgcctg ggcttgcatc 1708201 taataactgg ttcttctata aagaagccta cgatatggac atgttcaagg ttgtggatat 1708261 gatcgccact atccagcagc acattgatca gggaatcagc tttacattgt tcttaaaaga 1708321 cacaatgacg acccgagatt taaaccgaat cgatctgtat gcacatcata gaggaattaa 1708381 aaccatttac tatgcaagaa cgaaagatac tgggcaagac agctgccttt cttgtgttgt 1708441 ttgattaaag gagagtttat agtgacaaaa atttatgacg cagcaaactg gtcaaagcat 1708501 gaagacgatt ttacccaaat gttctataac caaaacgtga aacagttctg gcttccggaa 1708561 gagattgctt taaacggcga tctcctcaca tggaagtacc tcggaaaaaa tgagcaggac 1708621 acttatatga aggtactggc cggacttacg cttcttgaca cagagcaggg gaatacgggg 1708681 atgccgatcg tggctgaaca cgtagatggc caccagcgga aagcggtgct gaactttatg 1708741 gcgatgatgg agaacgctgt ccatgcgaag tcgtactcta atattttcat gacccttgca 1708801 ccgactgaaa cgatcaatga agtatttgaa tgggttaaac aaaataaata tttgcagaaa 1708861 aaagcgcaaa tgattgtcgg gctttacaaa gccattcaaa aagatgatga aatttcactg 1708921 ttcaaagcca tggttgcttc cgtctatctg gaaagcttcc ttttctacag cggtttctat 1708981 tatccgttat atttctacgg acaaggaaaa ctgatgcaaa gcggtgagat cattaacctg 1709041 atccttcgtg acgaagcgat tcacggcgtg tatgtcggtc tccttgctca ggaaatttat 1709101 aataaacaga cagaagagaa aaaagcagag cttcgtgaat ttgcgatcga cctcctgaat 1709161 cagttatatg aaaatgagct tgagtataca gaggacttgt acgatcaagt cgggctctca 1709221 catgatgtaa agaaattcat ccgctataat gcgaataaag cgctgatgaa ccttggattt 1709281 gatccatact tcgaagagga agacattaat ccgatcgttt taaacggatt aaacacaaaa 1709341 acaaaatcgc atgacttctt ctctatgaag gggaatggct ataaaaaagc gacagttgag 1709401 ccgctcaaag atgatgactt ttattttgaa gatgaaaaag agcagatata atatctgctc 1709461 ttttcggctt gaaggttcaa atgaggagga cgcagtaccc atgggaaaaa tggacgaaat 1709521 gattttagtt gccccgcgcg atgatgtgtt taaaaaagaa agcttaacct tccagggcgt 1709581 gtacagtgaa gatagcagag tagcagaaat catggctcag attgaagcgg cctatcgtga 1709641 aatgagaaga ggggacgcag aagaagatcc gcgtttcaag cagccgatac cttatgtcgt 1709701 cattaagcgt gaagatgaag tttttcttta cgagcggctg gctggcggcg gtgaatcacg 1709761 tctgcacaac aagctttctc tcggttttgg cggccatatg aacgccatcg aaggggcagc 1709821 ttcatttgct gaagtcttaa agctgaacac agaccgtgag cttgaggaag aactgcaaat 1709881 aaatgaagaa gataaacagg cgattgtcac actgggattg atcaatgatg atgaaaacag 1709941 tgttggcaaa gtgcatatcg gtattctttc tgcgcttcaa ttaaagcctg gcgcacaagt 1710001 ggaagtgaag gagaaagaac aaattgcggg taaatggatg aaagtttctg aattaaaaca 1710061 ggatgatatc tacaaccgtc tggaaacatg gtcacagttt gttgttgata ttcttgaata 1710121 aaaaaacccg gtttctcgcg atgaggagcc gggttttttt atgagacgct cgtccccgtc 1710181 tcggctatga ttctaggatc acaatagcgt caaagccggc atttttcgct ctggcagcga 1710241 gggtgtctgc attgtctttg gatgaaaatg cgccaatctg cactttgtat aatccgtcct 1710301 ttaaaaggac aatcgagtca aaacctttgg cttcggcatt acttgcgagc gagtcggcat 1710361 tcgctttgac tttaaatgcg ccgatttgaa ccttatataa ccctgagctg gaagtctttt 1710421 taaggttaaa ggcttgctcc agcccgtttg catgtcctct cgctaagctt tgaataaaac 1710481 tgctcgtttt cagcttattt gcatcggaaa cggtatcaat gaagccgttc tcggtcaaga 1710541 gggcaggcat tgccgactcc cttaggacgt ggaagttcgc tgtttttttg ccgcgatcgg 1710601 caaagtcgac agcttgtatc acttcagagt gaattgtcga ttgataagtc gtcgtcgggg 1710661 ctcctacatc tggataaata tagctttcaa aacctgtgcc tcccccggaa ttaacgtgaa 1710721 tggacaaaaa gaaatctgct ccccagttat ttgcggcatt tgtccggtcg tttaagctga 1710781 catattggtc gcttgtccgg ctcagcagca gagaaacgcc ttcatattca ttagttaata 1710841 tcgtacgtaa ggctaaagcg atttgcaggg ttaacgtttt ctcctgaagg ccattacctg 1710901 ttgcgcctgg atcagacccg ccatggccag gatcaataaa aattttaacc atttttcatc 1710961 acctcattac aggatatgaa aaaacacggc ttctgcttgt acgattatca ttcaactgaa 1711021 aaatgaggaa ataacccttt cacatccaga aattatttct cgggaaagcg cacaattcaa 1711081 catgaagcga caacagatac ggtccgacat gaaatctgtg catacgccat atgtttgtat 1711141 gtactatggg ttcggttaac ctgcactgat tcctgctggt tttaagcttt gcgttcatat 1711201 taaatcaagc atttaaaacg taaattgatg aggaaagctc ctttcattaa agacaccgct 1711261 ttataaatcg aaaaaaagaa aaacacttca ggtatcttag ggcgggtaat acgtttcgta 1711321 caaaaatcag cccgttgtat gaaaaagaaa taatgagaaa gaagctcact ataatactct 1711381 gacaaaatga ttaaaaacaa aatctcatgg tttgtccacc ccatgtccgt gaatacaata 1711441 agaaataaag tatttctcgg gaaagcgcag gattccttat tgttcccgaa aaaagcaatt 1711501 gtttcgacac atgataggcg tttgtcacaa tcggcatccg cttgaatatc atatagagag 1711561 aacagagagg tgaagatgtt ggagcgcgct gtgacttata aaaacaacgg acagatcaac 1711621 attattctga acgggcaaaa gcaggtgctg acgaatgctg aggcagaggc ggaatatcag 1711681 gctgcattgc aaaaaaacga agcaaagcac ggcattttga aggaaatcga aaaagagatg 1711741 agcgcattag ttgggatgga ggaaatgaaa cgcaacatca aggaaatata cgcctggatt 1711801 tttgtgaacc aaaaacgcgc ggagcaaggc ttgaaggttg gaaagcaagc gctgcacatg 1711861 atgtttaaag gaaatccggg aacgggaaaa acgacggttg cacggctcat cggcaagctg 1711921 ttctttgaaa tgaatgtcct gtcaaaaggc cacttaatag aagcggagcg ggctgacctg 1711981 gtcggggagt atatcggaca caccgcccaa aagacgagag atttaatcaa aaagtcatta 1712041 ggtggcattt tgtttataga cgaagcctac tcgctggcaa gaggcggcga aaaggacttt 1712101 gggaaagaag cgatcgacac acttgtaaag catatggaag acaaacagca tgagtttatt 1712161 ttgatactcg ccggatattc acgggaaatg gatcattttc tctcgttaaa tcccggactc 1712221 caatcaagat ttcccatctc cattgatttt ccggattact ctgtgaccca gctcatggag 1712281 attgcgaaac gaatgatcga tgaaagggaa taccagctca gtcaagaagc ggaatggaaa 1712341 ttgaaagatt acttaatgac agtgaaaagc acgacaagtc ccattaaatt cagcaatgga 1712401 cgttttgtca gaaatgtgat cgaaaaatcg atcagagcac aagccatgag gcttttaatg 1712461 ggagaccaat acttaaaaag cgacttgatg accatcaaaa gccaagatct ttccattaaa 1712521 gaagaagcat ctggatctgc atagacctct cagtttttga gaggtctgtt ttttgctcgt 1712581 atttccgctt ttcaaagcaa tcgatttgtg gtatacacat gcagggtttg gtatgataat 1712641 actactgccc aatatgcaaa agaaaggaac atccatttga acgaacaaga aacgattcag 1712701 gagaaagcca ttttagtcgg atgtcagctg ccgcatatca cggatgagca ttttgaaaat 1712761 tctatggaag agctagcatc tctgacgaaa acagcagacg gaaaagtact gaccagcgtc 1712821 acacaaaaac ggaacagggc tgacgccgct acatatatag gaaaagggaa ggtagaagag 1712881 ctgaaggcac tcgtggaaga gcttgaagct gatctcctca tctttaatga tgaactgtcg 1712941 ccaagtcagc tgaagtcatt ggcaacagca attgaagtga agatgattga ccgcacgcaa 1713001 ttgatattag atatttttgc aaagcgggcg agaacgagag aaggcaaact tcaaattgag 1713061 ctggctcagc tgcaatatgc actgccgcgt ctgacgggac aagggatcaa cctttcccgg 1713121 caaggcggag gaattggggc aagaggtccc ggggaaacga aactggaaac cgaccgccgc 1713181 catatcagaa atcgcattca tgaaatcaac acacagcttt ccactgtcat tcgccataga 1713241 agccgatacc gtgaaagaag aaagaaaaac ggtgtgcttc aaattgcgct tgtcggctat 1713301 acaaacgcag ggaaatcaac atggttcaac cgcctgacga gtgctgacag ctatgaagaa 1713361 gacctcctgt ttgccacgct ggacccgatg accagaaaaa tggtcctgcc aagcggctac 1713421 agtgttcttc tttcagatac agtaggattt attcaggatc ttccgacgac attgattgct 1713481 gcattccgct caacgcttga ggaagtaaaa gaagcggatt taattctgca tttaattgat 1713541 tcttcaaatg aggattatgc gggacatgaa aaaacagtgc ttcggctgct tgaggagctt 1713601 gaagcagatg atatcccgat gctgacggct tacaataaac gtgatcaaaa actgcctgat 1713661 tttataccga ccgccggaag ggatcacatt atggtcagtg cgaaatttga ggacgacgct 1713721 gcagccttta aagaagcgat tcagcgctat ttgcgccaag aactgttaac gtcttttgaa 1713781 gcacatgtgc cggcaagtga agggaagctc ctttccagaa tcaaatcgga aacgatggta 1713841 gaccgcttct attttaatga agaaaatgaa cagtatgaca tatccggcta tgtccaagaa 1713901 gagcaaagta tcatcggtga attaaagaag tatatgtagg aaggaaatat aaagacatgt 1713961 ttgacacatt aacacacgga gaattattga agaaaacggc aatggaagtg gaagcggaca 1714021 ttgccggcat tcataaacaa atagaagaaa tcagcgagcg aaatgagtgg agagtgcttc 1714081 aaagctatag aaaacacaaa gtaagcgaca ctcatttcac gccgtctact ggatacggct 1714141 atgatgatat cggaagagac acgcttgaaa gcatatatgc ggatgtgttt ggcggagaag 1714201 cggggcttgt aaggccgcaa atcatttcag gcacacatgc catctcaatt gctttgttcg 1714261 gtgtcctcag accgggggac gagctccttt atatcacggg caagccgtat gatacgctag 1714321 aggaaattgt gggcgtcagg ggtggagaaa acgctggttc gttaaaggat tttcaaatcg 1714381 gctataatgc ggttgatctg acgaaagacg gaaagataga ctatgatgca gtcgccgctg 1714441 cgatcaatcc gaagacaaaa gtaatcggca ttcagcgctc aaaaggatat gcgaatcgcc 1714501 cttctttctt aattagtgaa ataaaagaaa tgatccgttt tgtaaaagaa atcaatgaaa 1714561 atctgatcgt ctttgtggac aactgttacg gagaatttgt ggaagagctt gagccttgcc 1714621 atgtcggagc cgacctgatg gcgggatctc tcattaaaaa tcccggcggc ggccttgcga 1714681 aaacaggcgg ctacctcgtc ggaaaagcga aatggattga agcttgctca taccgtatga 1714741 cgtcacccgg catcggcaga gaagcggggg catctcttta ctcgctccaa gaaatgtacc 1714801 aaggcttctt tttggcgcct cacgttgtgt ctcaaagttt aaagggagcg gtgtttacag 1714861 cgagattcct tgaaaaactc ggcttcactt caaacccgaa atgggatgcg aaaagaacgg 1714921 atttaataca atccgttgag ttttctgaca gagaaaagat gattgctttt tgccaggcta 1714981 ttcaatttgc atcgccaatc aatgctcatg tgacgcctta tccagcctac atgcctggat 1715041 acgaggatga tgtcattatg gcagcaggga cgtttattca aggagcaagc atcgaattat 1715101 cagctgatgg ccctatccgc ccgccgtatg tagcgtatgt tcagggagga ttaacctatt 1715161 cgcatgtgaa gaatgccata tgcagtgcag tggattcatt gatgcaaaag caattaattt 1715221 aaatttttta aaaatttctc tggatttgat gttaagaatc cttacatcgt attgacacat 1715281 aatataacat cacctataat gaaactaagt taagaaaagg aggaaattga gatgagtgat 1715341 aatattcgcc gctcaatgcc tttatttcca ataggaattg tcatgcagtt aactgagtta 1715401 tcagcaagac aaattcgata ttatgaggaa aatggactga tatttccagc cagaagtgaa 1715461 ggaaatagac gattattttc atttcatgat gtagataaac tgttagaaat caagcacctg 1715521 atagaacaag gtgtaaacat ggcaggaatt aaacagattc tggcgaaagc cgaagccgag 1715581 ccagaacaaa aacaaaacga gaagacgaaa aaaccaatga aacatgatct gtccgatgac 1715641 gaactgagac agctcctgaa aaacgagctc atgcaagccg gccgttttca aagagggaat 1715701 acattccgtc aaggcgacat gtcccgcttc tttcattaat ccgttagcaa ctgttttgct 1715761 atatacattt accttttaag aggaggaatt ttaccaaatg gcaaagtaca ctagagaaga 1715821 tatcgaaaaa ttagtaaaag aagaaaacgt gaagtatatc cgccttcaat ttactgacat 1715881 tcttggaaca atcaagaatg ttgagattcc tgtaagccag cttggaaaag cgcttgataa 1715941 taaagtcatg tttgacggtt cttctattga gggattcgtt cgtatcgaag agtcagacat 1716001 gtacctgtat ccagatctaa atacatttgt tatcttccca tggacagctg aaaaaggtaa 1716061 agtagcacgt ttcatctgtg atatttacaa tccggatggc acaccttttg aaggtgaccc 1716121 gcgaaacaac ttaaaacgga ttctgaaaga aatggaagac ctcggcttca gtgattttaa 1716181 ccttgggcct gagcctgaat tcttcttatt caaattggac gaaaaaggcg agccgacgct 1716241 tgaactaaac gacaaaggcg gatatttcga cttagctcca actgatttag gagaaaactg 1716301 ccgccgcgat atcgtacttg agcttgaaga gatgggcttt gaaatcgaag cgtctcacca 1716361 cgaagtagca cctggtcagc acgaaatcga ctttaaatat gctggagcag tccgctcttg 1716421 tgatgacatc caaacattta aactagttgt caaaacaatt gcccgtaaac acggcctgca 1716481 tgcgacattt atgccaaaac cattgttcgg tgtaaacggt tcaggtatgc actgcaatct 1716541 atcactcttc aaaaatggtg ttaacgcatt ctttgacgaa aacgcagatc ttcagttaag 1716601 tgaaacagcg aagcacttca ttgcaggtat cgtgaagcac gcaacaagct ttacagcagt 1716661 aacaaacccg acagtaaact cttacaaacg tcttgttcct ggctatgaag caccttgtta 1716721 tgtagcatgg agcgcgcaaa acagaagccc gcttatccgt atcccggctt ctcgcggcat 1716781 cagcacacgt gttgaagtac gcagtgtaga cccagctgca aacccatacc ttgcacttag 1716841 cgtattgctt gctgcaggat tagacggaat caaaaacaaa ctggaagcgc cggctccaat 1716901 cgaccgcaac atctatgtga tgagcaaaga agagcgcatg gaaaacggaa tcgttgacct 1716961 tccagcaaca cttgcggaag cactagaaga attcaaatca aacgaagtca tggtcaaagc 1717021 gctgggcgag cacctattcg aacacttcat cgaagcaaaa gaaatcgaat gggatatgtt 1717081 ccgcacgcaa gtacatcctt gggaacgcga acagtatatg tctcagtatt aatatctcaa 1717141 tcccttggca ctaaaagtgt caggggattt tttatgttaa taggtaataa attatggagc 1717201 ggcatagtgt ttaacacagc cattaatcct cagacagtca aatagccatt tctactccgg 1717261 ttgaaagctt ctctattttt gcttcttatt tatctttcct gtattgatat atgtatgtag 1717321 ggttggactt ataacataaa ctattctggc cattccgttc tttcaattca tgaccgggct 1717381 tgccatcagc ataaatctag gctaacagtc tccatacatc ctgtgatcac ctttatcaaa 1717441 ctcttaaatg caacttacca ctaaccaatt ctttatttcg catagatcat ctttgtcatg 1717501 tgtttacaca agaatctgtt ttggactgag acactgaata taacaaaaca gtcaaaaatc 1717561 aatatttaat tcattctgtt taaactttct gaaaaagatg ttgaaaaagt cgaaaggatt 1717621 ttataatatt aagtcaagtt agtttgtttg atcaacaaac taatgaaatg aactttcatt 1717681 atccacaaga taagatctta ctaatatgga tggaaggggg ataagagggt cgatttaatg 1717741 gagctaaaca atataagaaa cgaaagaatg aggcttttat ccttttccag gtatataagg 1717801 tatgacgaaa aaagatgaat tttttgcttg ctgatcacca tatttttttg cactgttttg 1717861 aaagcgcttt tataaaagtt tactgaccgt aaattcgaga aattgttata ccgtttcaca 1717921 ctgttccata ttaaaggatc gaaaagggga gaaatcatgc tcagtgaaaa tgtaaagaag 1717981 attagcatgg ttgaaaaagt tggatatgcg tctggagatt ttgcttgtaa tttaatttat 1718041 gcaacagtgt ctacgtatct tttgttcttc tatacagatg tttttggttt atcggcagca 1718101 gcagccggta ctatgttttt agtggttaga ataatcgacg ctctcgctga tccttttatc 1718161 ggaacaatag ttgacagaac gaacagcaga tttggacgct ttagaccgta tcttttattc 1718221 ggagcttttc catttgtcat actggcaata ctctgtttta caacaccaga cttttcggat 1718281 atggggaaat taatatatgc ctatataacc tatgttggct tgtcgcttac atacacaacg 1718341 ataaacgttc catatggcgc gttaacttct gcaatgacta gaaataatca agaagttgtt 1718401 agtataactt ctgttcgcat gttatttgcg aatcttgggg gacttgtcgt tgcatttttt 1718461 gttcccttac tggctgctta tttaagcgat acttccggca acgagtctct tggctggcaa 1718521 ctaaccatgg gtattttggg aatgataggc gggtgccttt taatcttttg ttttaaaagc 1718581 acaaaagagc gggtcactct tcaaaaatcc gaagagaaaa ttaaatttac ggatatattt 1718641 gagcagtttc gtgttaatcg tccacttgtt gtattaagta ttttctttat tattattttt 1718701 ggagtgaatt ccatcagtaa ttcggttggc atttactacg taacgtataa cttagaaaga 1718761 gaggatttgg tgaagtggta cggtttgata ggaagtttac ccgctttggt cattttaccg 1718821 tttattccaa ggcttcatca atttttgggg aaaaagaaat tactaaacta tgcattatta 1718881 ctgaatatta taggcctctt agctttactg tttgttccgc caagtaatgt ttacctcata 1718941 cttgtctgtc gattaatcgc tgctgctgga agtctcactg ccgggggata tatgtgggcg 1719001 cttattcctg aaacaattga atatggagag tacaggactg ggaaaagaat gggtgggctc 1719061 atttacgcta taatcggatt tttctttaag tttggtatgg ccttaggagg agttgttccg 1719121 ggtctggttc ttgataagtt tggatatgta gcaaatcagg cacaaacccc ggcggcctta 1719181 atggggattt taattacaac aaccattatt cccgtgttct tgcttgttct agctttaatt 1719241 gatattaatt tctataactt agatgagaaa aaatataaaa acatggttcg agaattagag 1719301 aatagagaca aagtttattt ggatcatatt gatgatttca aggcttaaaa aagaaaataa 1719361 actgaggagg agtcccaaat gaagattacc aatcccgtac ttaaaggatt caatcccgat 1719421 ccaagtattt gtagagcagg agaggattat tatatcgctg tatctacatt tgagtggttt 1719481 ccgggagtcc agatacacca ctcaaaagat ttagtaaatt ggcacttagt tgcacatcca 1719541 ttacagagag tttcacaatt agacatgaaa ggaaacccaa attcaggtgg agtttgggca 1719601 ccatgtttaa gctatagtga tgggaagttt tggctgatct atacggatgt taaggtagta 1719661 gatggcgcat ggaaagattg tcacaattat ttagttactt gtgaaacgat taatggtgat 1719721 tggagtgagc cgattaaatt aaatagctcg gggtttgatg cttctttgtt ccatgatacg 1719781 gatggaaaaa agtatttatt aaatatgtta tgggatcacc gtattgatcg gcactcattt 1719841 ggaggaattg ttatacagga atattctgat aaagagcaaa aattaatcgg taaaccaaaa 1719901 gttatatttg aaggaactga tagaaaactg acagaagctc cgcatcttta tcatatcggg 1719961 aactattatt atttattaac tgcagaagga ggaacacggt acgaacatgc tgctacaatt 1720021 gctcgttctg caaatattga ggggccatat gaagttcatc ccgataatcc aattttaacg 1720081 tcatggcatg acccaggaaa tccattgcaa aaatgtggtc atgcatccat tgttcaaaca 1720141 catacagatg agtggtattt agctcattta acgggacgtc ctattcatcc tgacgatgat 1720201 tcaatttttc agcagagagg atactgtcct ttgggcagag aaacagctat tcaaaaactt 1720261 tactggaaag atgaatggcc ctatgtagta ggtggaaaag aaggaagctt ggaggtagat 1720321 gcaccttcta tacccgaaac aatatttgaa gcaacgtacc cggaagttga tgaatttgag 1720381 gattcaacat taaatataaa ttttcaaact ttaaggattc cattcacgaa tgaattaggt 1720441 tcattgactc aagcgccaaa tcatttacga ttattcggtc atgaatcatt gacctcgaca 1720501 tttactcagg catttgtagc cagacgctgg caaagtctcc attttgaagc cgaaactgct 1720561 gttgagtttt atccggaaaa ttttcaacaa gccgctgggt tggtgaatta ctacaataca 1720621 gagaactgga cggctcttca agtcacgcat gatgaagaac ttgggcgcat tcttgaatta 1720681 acaatatgtg acaacttttc tttttcacag ccattaaata ataaaattgt tattcctcgt 1720741 gaagtaaagt atgtatattt aagagtaaat attgaaaagg acaaatatta ttatttctat 1720801 tcttttaaca aagaagattg gcacaaaatt gacattgcac tggaatcgaa aaaattatca 1720861 gatgattata tccgtggggg aggattcttc acaggggcct ttgtagggat gcaatgccaa 1720921 gataccagtg gtaatcatat tccggccgac tttagatatt ttcgttataa agaaaaataa 1720981 tttgcacatg aaaaaggaga tttctatttt agaactcctt tttcatatga gaaggtgcca 1721041 tgtcactatt gcttcagaaa tactcctaga ataaaaaaac tcatctttaa agatgagctg 1721101 tccattccat aaaaaattac attgtaatca tgtccagaaa atgatcaatc acaatggagg 1721161 acattcctaa tgccggtgca ttctgtccta aggaagatgg caataattca tagctattgc 1721221 ctaattggga ataaaccctt gatgatactt cacttctcat tgaatttaaa accataggat 1721281 gcgattcaat tatgctattt cttaaaatta cggcttgtgg gttgaaagta tttagaatat 1721341 tggtaaggcc tattcctaaa tagaatccaa aattttgtaa tgcatttaag gttccgatat 1721401 cattcagatg ggcgaggttt atgatatctt gataggacag ttttttctct ttggtctgaa 1721461 gagattttaa taaagccttc tctgaagcat acaattccca gcatcctcgg tttccgcaac 1721521 tgcatttagg accattaaag tctattgtca tatgtcccat ttctccagag aagccgctta 1721581 ctcctctata taaatgattg ttgataataa caccgatccc tattcctgtg ctgatactta 1721641 cgtaaataat gttatcgtga ttttttgcag ctccaaatac tttttctcca tatgcgccag 1721701 catttgcctc attttcaata aaaacaggca cattgtactt ctcttgtatc gaagatttta 1721761 agtcaatatc tctccagttg gagttcggag tgaaaacaat tttttgatct ttatcaatga 1721821 gtccaggcac gcaaatacct ataccaataa gcccgtacgg agattggggc atttgcgtaa 1721881 taaagtgatg aatcatatca atcaaaatgt ctttcgttat ttctggagaa ttggattcca 1721941 aatggcggta ttgatcaaga acgattgttc cttcaaggtc tgttaaaatg ccattaatat 1722001 aatccacacc aacatctatt ccaacggagt atcctgcctt tttattaaaa acaagcatga 1722061 caggtcttct tccgccactt gattgtcctt gacctatttc aaataccata ctttctttca 1722121 ttaacgtgtt tacctgtgat gagacagttg atttatttaa tccagtcatt tcagataatt 1722181 ttgctcttga aataggtgaa tttttaagga tttcttttaa taataacttt tgatttactt 1722241 ttttgacaaa ggtttgatca gcgatatcca cttcatccac tccatttgtt taatctttaa 1722301 attaagtatc aacatagtac atagcgaatc ttccctttat tatatctaat gtgttcataa 1722361 aaaactaaaa aaaatattga aaatactgac gaggttatat aagatgaaaa taagttagtt 1722421 tgtttaaaca acaaactaat aggtgatgta cttactatat gaaataaaat gcatctgtat 1722481 ttgaatgaat ttatttttaa gggggaaatc acatggctca atctcattcc agttcaatca 1722541 actattttgg aagcgcaaac aaagtggttt acgaagggaa agattcgact aatcctttag 1722601 catttaaata ttataatcct caagaagtaa tcggcggaaa aacgctgaaa gagcatttgc 1722661 gattttctat tgcctattgg catacattta ctgctgatgg tacagacgtt tttggagcag 1722721 ctacgatgca aagaccatgg gatcactata aaggcatgga tctagcgaag atgagagtag 1722781 aagcagcatt tgagatgttt gaaaaactag atgcaccatt ctttgctttt catgaccggg 1722841 atattgcacc agaaggcagt acgctaaaag agacaaacca aaatttagat atgatcatgg 1722901 gcatgattaa agattacatg agaaatagcg gcgttaagct attatggaat acagcaaaca 1722961 tgtttacgaa tccccgtttc gtccatggtg ccgcgacttc ttgcaatgca gatgtgtttg 1723021 cgtatgctgc agcacaagtg aaaaaagggt tagaaacagc aaaagagctt ggcgctgaga 1723081 actatgtatt ttggggcggc cgtgaaggat atgaaacatt gttaaatacc gatttaaaat 1723141 ttgagcttga taatttggct agatttatgc atatggcagt ggattatgcg aaggaaatcg 1723201 ggtacacagg gcagtttttg attgagccaa aaccaaaaga gccgaccacc catcaatacg 1723261 atacagatgc agcaacaacc attgcctttt tgaagcaata tggcttagac aatcatttta 1723321 aattaaatct tgaagccaat catgccacat tagccgggca tacattcgaa catgaattac 1723381 gcatggcaag agtacatggt ctgcttggct ctgttgacgc aaaccagggt catcctcttt 1723441 taggctggga cacggatgaa tttccgacgg atttatattc tacgacatta gcaatgtacg 1723501 aaatcctgca aaatggcggc cttggaagcg gcggattaaa ctttgacgcg aaggtcagaa 1723561 gatcttcttt cgagcctgat gatctaatat atgcccatat tgcagggatg gatgcatttg 1723621 caagaggatt gaaagttgcc cacaaattaa tcgaagatcg tgtgtttgaa gatgtgattc 1723681 aacatcgtta ccgcagcttt actgaaggga ttggtcttga aattatagaa ggaagagcta 1723741 atttccacac acttgagcaa tatgcgctaa atcataaatc aattaaaaac gaatctggaa 1723801 gacaggagaa attaaaagcg atattgaacc aatacatttt agaagtataa caggataagc 1723861 tccagatcct gctatcaata ccaagtcact gaattacccg tcatgattcc tttcctattg 1723921 cttgttgtta tgacgggtaa cttctataat taggatttat ttagagtgaa tggtttttta 1723981 aaagggcaag gagtgaaaaa atgaagtatg tcattggaat agatcttgga acgagtgctg 1724041 ttaaaaccat tttagttaac caaaacggca aggtttgtgc agaaacgtcc aaaaggtatc 1724101 cgctcatcca agagaaggcg ggatatagtg agcaaaatcc tgaagactgg gttcagcaaa 1724161 caattgaagc attggctgaa ttggtttcta tatccaatgt tcaagccaag gatattgacg 1724221 ggataagcta ttcgggacaa atgcatggat tagtactgct tgaccaagat cgtcaggtgt 1724281 tacgtaatgc aattctttgg aatgatacca gaacaacgcc tcaatgtata aggatgaccg 1724341 agaaatttgg cgatcatctt cttgacatca caaaaaaccg tgttttagaa gggtttacat 1724401 tacctaaaat gttatgggta aaggaacatg aacctgaact ttttaaaaaa actgctgtgt 1724461 ttttgcttcc gaaagactac gtgcgattcc gtatgaccgg tgtcattcac accgaatact 1724521 ccgatgcagc aggaacttta cttttacata ttactcgcaa ggagtggagc aatgatattt 1724581 gcaatcaaat tggtatttct gcagatattt gtcctccgct tgttgaatct catgattgtg 1724641 taggatcgct gcttccgcac gttgccgcga agaccgggct attagaaaaa acaaaagtgt 1724701 acgctggggg agcagataat gcttgcggcg ctattggagc aggtatcctt tcttccggaa 1724761 aaacattatg cagtattggg acgtcagggg tcatactttc ctacgaagaa gaaaaagaaa 1724821 gagactttaa agggaaagtc cactttttta atcatggaaa aaaggattct ttttatacga 1724881 tgggcgtcac gctcgctgca ggatacagct tggactggtt taaaagaacg tttgcaccaa 1724941 acgaatcgtt tgagcaatta ttgcaggggg tggaagctat tccgatagga gccaatggac 1725001 tgctatacac tccttatttg gttggtgaaa gaacgccgca tgctgattct tctattcggg 1725061 gaagcttgat cggaatggat ggagcccata atagaaagca ttttttgagg gcaataatgg 1725121 aaggtatcac attctcttta catgaatcaa ttgagctatt ccgcgaagcg ggaaaatcag 1725181 ttcatactgt tgtttctatt ggtgggggag ctaaaaatga tacgtggctg caaatgcaag 1725241 ctgatatttt caatacgagg gtaattaagt tagaaaatga acaagggcca gctatggggg 1725301 ctgcaatgct ggctgccttt ggaagcggtt ggtttgaatc acttgaagaa tgtgcagagc 1725361 agttcattcg tgaggctgct gcattttatc caaaggcgca aaatgttcaa aaatataaaa 1725421 cactatttga tttgtataag aacatttaca ctcacacaaa ggatctcaat acagctttga 1725481 agagctttcg aaaaaactaa tgatgttatt gtctggagat caaccgaaga acaattaatg 1725541 atcaatcatc atcaaaggcc tttgataaca tggctgcctt cttttgaaaa gatggtgaga 1725601 ataaggtatc gcaaccttta aacagtattg gagtatccag cagacaaaac gaacgagtgg 1725661 aaccgtattt tgtcagcgaa cacttcaaga agtggggaag cttaggaatg ccaatgggta 1725721 agatgtatga aaccgcgcta acgacggtag agggatctct tgatttatga agaaatagga 1725781 aggatgttaa cacacaaata acccctcaca ttgacgtgaa ggggtgtttt ttattgttac 1725841 tatacagcgg aaattttaca ggctagttgc atgattttag cttgttaagc agaatggaac 1725901 tagactctcc atcatctctt tctcattctt tggaaactgc attctgctag gtttgctgct 1725961 ttttttaaca aacagtgttt ttctatttca cacagccatt aaatcctctg ttcgtcacat 1726021 aaccgctctt actccaaatt gacagtttat ctgattttgc ttcttgctca tctagtctga 1726081 attggtctat gtattttgtg ttaggctcat atacatatgc tactctggcc aatccctctt 1726141 tcaataatgt ctcttgaaca gatttgccgt caacataaac gtatgctaac agtcttccat 1726201 acttatctct gcgatcgcct ttatcaaatt ccagctgtag cttaccgctg ttgaccaatt 1726261 ctttatttcg tttcgacgca tcctcaccgt atggttgaac acaagaattt ggtttcttcg 1726321 tctcaggtgt atcaacgagc aagtagcgaa ctgtgtcttt ctttccgttg taaataacct 1726381 taatcgtatc tccatctatt gctctatcta atgtaacatt gaccaatttc ttctgatttt 1726441 ttgaatgagg cgtgccagcc ttttgttctg tctgattata ttcattagag tgagtatctt 1726501 gagagacttg ctccgtccca ttagaatctg aatggttttt ggctgcgtga tttgatccgc 1726561 aagctgccaa agtaatactt aaaacgattg cgatcatact gatcaaaatc ttcttcatat 1726621 tgattccctc tttatcattt tctcttttcg cgattaaaca tcatcattat aacgatatgg 1726681 acattttttg tgaatggaaa acttcaaggg aacttataac actccaaatt gccaatagtt 1726741 aacttcacaa cgagatgatc aaaacatcac catcacatag cggaaataaa taatcctgaa 1726801 aataatattg actgaaaatg cttttagaat tatgataata tgagaaatga caataatgtg 1726861 acaaagacat tactacaaca taacaactaa tagcttaggt ttattctatt ggttaaaaat 1726921 gtaaacggtt acaaatccag aggcgaaaat ctaagataga gatgacttta gttttgactc 1726981 aatatccaca ctgaaagagc ttattaagta ttcttaaagg caggggaaat ggatatgaat 1727041 gaacatcgaa atcgaaggtt gaaattaata atgatttcag caacttttgg agggcttctc 1727101 tttggatatg acaccggagt tataaatgga gctttacctt ttatggcaag gccagatcag 1727161 cttgatttaa cacctgttac agaagggctt gttacgagta ttcttttatt aggtgccgcg 1727221 tttggagcgt tgttatgcgg aagattggct gatcgatatg gccgccgtaa aatgatcctt 1727281 aatctttcct ttttattttt cctggcatca ctgggaacag cgttagcacc taatgttttc 1727341 atcatggcgg tctttcgttt tttactgggg ctggctgttg gaggagcctc ggcgatggtg 1727401 ccggcctttt tagcagaaat ggcaccgcat gaaaagagag ggcgtatggt aacccaaaat 1727461 gaactaatga ttgttggcgg gcaattttta gcatatgttt ttaatgcgat cctcggtgta 1727521 acaatggcaa atacgggaca tgtttggaga tacatgctag tcatttgtgc tgtaccggct 1727581 atcatgttat ttgccagtat gcttaaggta ccagaaagcc cccgatggct aatctccaaa 1727641 ggcaaaaaca gtgaggcgct gcgagttctt aaacaaattc gagaagataa acgtgcagaa 1727701 gctgaatgta gagaaattca agaagcggta gaaaaagata cagcactaga aaaggcatca 1727761 ctcaaggact tttctacacc atggctgcgc cgtcttttat ggattggaat cggtgttgcc 1727821 atcgtgaatc aaattacagg tgtgaactcg attatgtatt atggcacaca aatccttaaa 1727881 gaatctggtt ttggtacaaa agcggcttta atcgctaata ttggaaatgg gctgatatca 1727941 gttattgcag ttatatttgg gatttggctg gtcggaaaag tgagacggcg tccaatatta 1728001 ttgattggtt tggcagggac gactacagcg ctcctattga ttgcgatttt ctcaattgtg 1728061 cttgatggat ctatggcact tccttatgta gtgctttctt tgaccgtttt atttcttgcc 1728121 tttatgcaag ggtgtgtagg acctgtgact tggcttgtca tagcggaaat attccctcaa 1728181 aggttaagag gacttggttc tgggataagt gtttttttcc tttggatatt aaactttgtg 1728241 atcggttttg ctttcccgat cttgcttagc tctgtaggtt tgtcttttac attctttata 1728301 tttgtggctt taggtgtatt ggcaatcggt tttgtgtaca aattcatgcc ggaaacaaaa 1728361 gggcgtacac ttgaagaatt agaagagcat tttcgttctc gacacgatca taatactcct 1728421 gaacaatcag ttattgaggt ataaatatgt tgaaaatctc tcttcttata ggagggattt 1728481 ttttagtttc agaaaaaaca aaatccctct ggtagaggga ttttgattca gcattttaag 1728541 atgttctaca cgtataatac tggagttgat actttaaaaa tctcgccatc tcttatataa 1728601 aaacgaggga tgcggcggct taatgtagac acgacttcat agttaatcgt attgagcatt 1728661 tcagccactt catcaacgga aatctcggct cctttttgct taccgtaaat cacgacttca 1728721 tctccttgtt taccttcacc gttttctcct aaactgacca tgatcatatc cattgttact 1728781 cttcccgcca ctggcactcg ttttccgcga tgaagaacaa acccgcgatt ggaaagggca 1728841 cgagaatagc cgtcagcata gccaatcggg agtgtagcaa ttacttcatt aggttctgcg 1728901 atgtatgtag caccatagct aacggttcgg ggttctgtcc gcatggtttt cacataagcg 1728961 atgcgtgcct ttaaacttaa cgcaggttca agcttaacga gatttagttg tttaatatag 1729021 gctgaaggat ataaaccata taagccgata cctaaacgga tcatatcagc gctaaattcc 1729081 ggaaatgcga tagctgcagc cgtgttgcac atatgcacgg tgggcagctc aatcccctgt 1729141 ttttttaaaa agctgagaaa actgatgaat ttttcatgct gcagctttgt gagtgttgtg 1729201 tccggttcat cagctgtcga aaaatgtgtg aaaatccctg tccatctgag gaatttactt 1729261 gcctttaagg ctttcactac ctctaaaagt tcttcctttg tgcgtacacc taatcgtccc 1729321 atgccggtat ccacgttaat atgaatggcc agccggttag cactcgcttc tttttccaat 1729381 atctcgtttg cttctttcat ccaatcaacc tgaaatgctg ataatgttat attccaagct 1729441 gctgacttct ttacacaact aagggatgta aaaccaagca caaggatagg tgctgtaatc 1729501 ccagctttac gtaaaacgat tccttcctcc acactggcaa cagcgagctc actcgccccg 1729561 tgttccagtg catggcgtgc cacttctata gacccgtggc cataaccgtt cgcttttaca 1729621 acagccataa ttttgctctt atgtggaata tgacggcgga tcgctcgcaa attcttttta 1729681 acggcatcaa gattgacttc gatccaaact tctcggcaaa gctttatcat caacgcttcc 1729741 ttccttctta tggattataa ataccaccta ttgccgcaag aataaatgtt aattgttgga 1729801 tgattcgatc ttattttatt caactttatt tgaaatcatt caacagcaaa tccatgtgat 1729861 acgagaaggt gcctatcaat gttcgaataa tagcaagtac gggatacatg aggcttgtaa 1729921 gtggggtgtt aatggatgcg gcgaccgagg attacaaaaa tgattatttg ttttgggaca 1729981 tttttttcta agggtagatg ataacgagaa atctaatcag gaaatactta ccgttgttat 1730041 gaacattgaa gaacctttta aatgagaagg gctgaggaaa ttctgtaaaa gataatcggt 1730101 tgaaaaggca gtcgattcct tgttccataa acctaacatc agagtatata attatactcg 1730161 tattcacaaa aatcgtttaa gtaaggggta tacatgaata ggggagttag ttttcaaata 1730221 ccgaatgaat atggaaattt tctatggaga atactgcagc cggtagaaat agctaattat 1730281 aggtggcaaa cgagtgggga atcttatttt gttgtagaag gagagctcga tgatgaggag 1730341 ctttttcatg actacgaaat tgttgagggg gcagtttttg agcaacaatt aaaaacgaat 1730401 cagtactata ccattttcgt tgaactgaaa gcatttccat atggaaaaat ggttaatcaa 1730461 gtcaatacat atgaagagtt tgctgacagt gattgcgaac ttgtcctttt gatagcagat 1730521 aatagctacg tttcgattta ctgtaaaaac aaaaatatca ttgaaaaact ttacttcaat 1730581 gctttacagc atgattttga agacgttcaa tttataactg atgaaaatga cacaagaaca 1730641 agccttactg tatgatactc aataaaaatt aaaggagcta gtacatgaca atgcaaatta 1730701 aaatcaagta tctagatgaa acacaaacaa gaatcagcaa aattgagcag ggagactgga 1730761 ttgatcttcg ggcagctgaa gatgtaacaa tcaaaaaaga tgaatttaag cttgtcccat 1730821 taggtgttgc aatggagctg cctgaaggtt acgaagcaca tgtcgtccct cgttcaagta 1730881 catataagaa ctttggcgtt attcaaacaa attcaatggg tgttatcgat gagtcatata 1730941 agggagacaa cgatttctgg ttctttcctg cttatgcatt gcgtgatact gaaattaaga 1731001 agggtgatcg tatctgccag tttagaatca tgaagaaaat gccggcggtt gaattggttg 1731061 aagtcgagca tttgggaaac gaggatagag gaggactcgg ttcaacaggt acgaagtaaa 1731121 caaaataaat ccttggctgt cttcatgctg tgtgattgat caatggaggt ttcagccaag 1731181 gtacatataa atattatgta taaaatgaat attttaatac gaaggattta attaaaaaca 1731241 aagtttaaaa agggaagttt tgaaaaagtg aaatagtaat aactaaagtc gataaagaac 1731301 ctaaagatgt caaagaaaca atttttctgg tgctttgctt ttttgaaggt ttacttagct 1731361 cgtggataac tgccccccat aaaagcatgg atgctaaaat tataatactt atatacataa 1731421 agatgctcct tttattatat ttacagtttt tacattttta tcgattttac cacatttagg 1731481 attgagttgt cgatgaaaca agcatctcta taaagaaata cttttatcta aatttttata 1731541 aataggggaa ggcaactaaa aactagtaat gccactaata ataagccaag ttaaatgact 1731601 tgtgttcatt aataattgaa ttttacagca gccatgagca caaaaaaatc tgagttcgtc 1731661 gataaatatc ataaaaaagc ccccggtatg tcgccaggga ataaatagac gtttaagaga 1731721 tttagtgatg ttttttatat gattcgacaa aatcataata atgatcatcg tcatcataat 1731781 actttttttc gtaatgataa tcgtgatcat cgtaatactt tttatcatgg tcatcatact 1731841 ttttgtcgta atcataatgt tttttatcat gatcataata cttgtcgcaa tcataatgct 1731901 tcttatcatt gtcgtaatac tttttgtaat atgttttttt ccaagtataa tactcttctt 1731961 tatatttttt ataataaccc aattaaattc ctcctttatg ttattcgaat ttaatttatg 1732021 aagtttaaat gatatggtat ggtcaaatga aataagaata gtaaaaagag gctgtttaaa 1732081 acactttctg aaaaacaaaa cggatagctg tttatgaaaa taagagcgag agagagcact 1732141 caatcactgt aaaataatag taaagtgtat agagagatta gtatacgtaa aaagggactt 1732201 tctcattgaa gaatatttga acgttatggt taagattcaa gagctctatg atgtgatttt 1732261 tcacactgct tttgaaggat ttagagttag acatcaaaaa caaacagcaa aaccggctag 1732321 aaacagatca tataaggaat gaaccgctgc caaatatcat aaaaaagttg ttaatgatca 1732381 aatgaatgaa attagagaga atttatttta aagaaagccc aattgcacat ggacaaatga 1732441 caattgatat tgaggtaaaa tacaatgcat taaatcagaa aaagctattg gaggatttaa 1732501 tgtgtttaga caatttccaa tttggtatac acaaacacct gactatttga atttttatgt 1732561 accgcaatat caaaccattt cgtataatcc tcaacaatgt tatcaacggt gtatgtacca 1732621 aactggcggt aactatgagc tatgtgacag actatgttat ggagaaatac aggtgtaaaa 1732681 gagggggatt aactcctctt taaacacaca gtgagtggaa taagatcctc actttatctg 1732741 caagtgctta gtatttgcga taatattgca ttcgtaataa attatgctta gcaactgaaa 1732801 atgaaagaag gatatgaata gtcatgacgc aattcgataa acaatacaat tcaattataa 1732861 aggatattat caataatgga atctcagacg aagagtttga tgtaagaacc aagtgggact 1732921 cagatggaac accggcacat actctaagtg taatcagtaa gcaaatgaga ttcgacaact 1732981 cagaggttcc gattttaacg acaaaaaagg ttgcctggaa aacagccatt aaagagttgc 1733041 tctggatttg gcagctgaaa tctaatgatg ttaatgattt aaacatgatg ggcgtccata 1733101 tttgggatca gtggaaacaa gaagacggaa ccatcggaca tgcatatgga tttcagctgg 1733161 ggaagaaaaa cagaagtcta aatggagaaa aagtggatca ggtagactat cttcttcatc 1733221 aattgaagaa caatccatct tcacgcagac acattacaat gctgtggaat cctgatgaat 1733281 tagacgcaat ggccttaacg ccatgtgtat acgagacaca atggtacgtt aaacatggga 1733341 aactccacct tgaggtaaga gcacggagca atgatatggc attgggaaat ccattcaatg 1733401 tattccagta taatgtgttg cagcgcatga ttgctcaagt gactggttat gagcttggtg 1733461 aatatatctt taacattggg gattgccatg tgtacacacg tcatatagac aatttgaaaa 1733521 ttcaaatgga aagagaacag tttgaagcac ctgaactatg gatcaatcct gaagtgaaag 1733581 atttttatga ctttaccatt gatgatttca agttaatcaa ctataaacat ggggacaagc 1733641 ttttatttga ggtagcggtt taatgctgcc tttttattgt gcagtgaata gatagcaggt 1733701 atcctaattt cattaagcaa tctggaagat gaataaaaat tgaaggacaa acacgtataa 1733761 tacataaaaa agattaactc tacagttaat cttttttatt cagaagaaaa tatcctaact 1733821 ttgaaactaa atacaaagta aaagcaatca ttacagttct agatattaca attccatgaa 1733881 tagctagatc atatccagca ggtatcaacg catttgtatt acacataaaa tatatagata 1733941 ttagaagtgc tacaataact aaaatcattc caaaaagact tgttttttca tatttcatac 1734001 caatttccac ccttattaaa gttaggttta aacaaaagag ctgaagaaac gaactatgac 1734061 cagtatgctc caaggaaaac cgccagacaa tgctggcggc tttttgctgc ttcgtttatt 1734121 tattaacaga gatcgtaacg ttatttcctg caactgaaac ctttgcgaaa tcctgtgtat 1734181 ctaccacagg agtgacggct ttattgtcga tagtgatgtt gttaaaagag gtcgaaaagg 1734241 ttgctttgat cgcatcacgc tggctttcat acgaaacagc cgcggtagca agtgttttcc 1734301 attttgaaat cgtgccgatg ttggttcctt gaatttctgt gataatccgt ccggtgtagc 1734361 cgtcattgtt cgttccccaa agggtcatgc gcgtattgcc gcttaaattt ttatagattg 1734421 tcatttggac tgtgcttcca gggcggaagc ctttattgta tgtgaatttg tcttttcctt 1734481 cgatgtacgt ttcttcattt ttggacccaa ccttcatgag gggcttccag acgttgtatt 1734541 gtttgctgta ctgaagcccg atatcggctt cagttccgct tgttgcccta aagccagaat 1734601 aaatataggg agtagagacc gagtcgttgt ttttgacagt ttcaggaagc acgattttag 1734661 ctgtaaaaac ggcgcccgta ctgttcaggt agacacggcc gccgattccg ttaggcagct 1734721 cggatgctgc ttttgcgact tgagcgtctg ccgcgggtaa acctggtata cctgatgaaa 1734781 gggttccgaa aagaactgct gttcctactg cacctgcaat caatactttt ttcaccaaaa 1734841 ttcccccttt tgatagtggt ttcgccattt attatacctt attttggaac tggatttacg 1734901 tatataaatc gacaaaatat ttcattttga atgatgtaag gtcgaaacgc ttcgccaatc 1734961 tgaaagctat atacctttat cagaggaaag aatgagatca cattcgtttt aaccgatttg 1735021 aaattttcct caaaataaaa gtacaaatgc ttaaagaaac gattattaaa agaatgcccg 1735081 ctatcgtttc caagcctgta aaaaagaggt gacgtttcat caatgtctgt ccttgtaaaa 1735141 tgataaaagc acagataccg actaagaaaa gaaaacaaat acttaggatt gctaacgctt 1735201 tacgtgagta tgttttcatt tcatctttaa aatacagcaa tacgaaaata aagcagataa 1735261 cattggctat tgttctaatc acctcaaagc ttttcatgac aactgatata aatagacaaa 1735321 gtaaaatgag ataaaatacg atgtttctat acaaaaaacc tctcctttta tgtaggatcc 1735381 tcaaagagtt tataaaagtt tctttgtaac tgcaataaat tgaatgcgct cacttatgaa 1735441 ctaactaaac tatgtactaa atattcacta ttctttttca gattcagtca ccaaggtttt 1735501 catagaaagg gaagcttcag aaatatacat atagtgcaca aacaaaaaag acccggcaat 1735561 agccggggga aagtaaaaac gaggagatgt taatggcgtt tagtagtgtt ttttatgctt 1735621 tttatactct acaacataat catagtcttt tttatcgtga tcataatatt ttttatcata 1735681 gtcatcatat tttttgtcgt aatcacagtc ataatctttt ttatcatatt cgtaatactt 1735741 cttataatac gtttttttga ccgtataata ctcttctttg tattttttgt aataacccat 1735801 atatactcct cctttatttt tactacgctt tattatacgg cgagtagatt ttgcggcttg 1735861 gacagttaaa atcatagaag gaaaaaaggg ctgtccaaat gatagaaaaa gacagatgac 1735921 acaaaaacaa atcaaaataa agagccgatt tttcatcggc ccaaacgatt tatcctacat 1735981 ttgtttgtct tctttgtttt ctgagtcatt ttttctgata tcctgagtca gtccgcttgt 1736041 tgcttgttta aattctgata aggcttttcc tgctgcacgg ccaagcgccg gcagtttatc 1736101 aggcccaaat actaaaaaac ccacaaacaa aataacgagt atttttgtga agcttaattc 1736161 catatccttt tccccctgat tgaagtacaa ccttttaaac aaattataag agatagcagt 1736221 acaaatggga atgcatttat tttgaacatt ttaaaaccag cacaaagacg gattcataaa 1736281 acggctgctg ctgaatataa tgtccaatgc cacctgccta agaagcagga ggcaggctgg 1736341 atcaattatg tagctctgcc ggaaatgata caaacgtagc ggctatcatt gacatagagg 1736401 agtggtgtag ctgatgagat tcactaaggt agttggattt ttgtctgttt tagggttggc 1736461 tgcggttttt ccattaacgg cacaagcaga aaaagccgga actgcggggg ctggagagtg 1736521 ggataagttg gggacttaca catatactta ctcaagtccg acggtatact cgaccggagg 1736581 agattttaga gtgtgccttt caggaagcac tcctttttct gtttcactgc acttatatga 1736641 ggatgatccc ggtgacaatc ctgatgatta tgtaggggca aactattttt cacccggaga 1736701 atgccacacc tttggcagta ttggaaaatt tgtagatggg agcaataaca aggccgagtt 1736761 ctttgttacc gattactctg gtaaatctaa aactgttacg ttttatgatt gatggactca 1736821 aattgtgaag tataaccctt ggaaaaaaac aaaaaagaga gatacctctc tcttttttat 1736881 tcttcgacag ccttacgaag ccgttcattt acaatgccag tccagccgcc atccatctta 1736941 ccgcgaacga cggagctttt ctcgtttgct ttgccgatca cttcattcgg ctctttccag 1737001 ccgctgtgaa taagggtaaa ccctgtcttt tcccccaagt cttctaattg aaaggtaacg 1737061 acccatcctt ctgtatccca ttcaaaagaa agttcagttg gagcttgaac agccaaaact 1737121 ttacaagggg acggcccaaa cggcgattgt aagtgaaatt cttgtccttc tttgagctga 1737181 aagtcattgg gcataaacca cttggcaatg ccttctgaag tagagactgt ctcccagact 1737241 ttctgaatgg gagcctccag agtaatgctt tttgtaatat ccggtaatgc attttcgttg 1737301 ttttgagcca tttcgtttac ctcttgacat atgatgtttt ttcaattcaa tcatataata 1737361 actaataaga tcatgtccat agcgtgcatt atttatgcta gagctgctgt tgaacagcgt 1737421 gtcagtcgcc agtctgatct gtgaatggga gaattctgca tgcgcgaaaa agagagagag 1737481 gtgtatgttg tcatttcgtt cattcttgtt tgcagccgca actgttatgt ttgaactggg 1737541 attcctgttc agccaattta ttttgcgatt tttgttttaa tagtaaatga gccattttct 1737601 aaaacaggag gttttttatg cttggaaaaa tcaaagcagc cattgataat agtccaggga 1737661 agccggccag aattttagtt agtgaaaaag cgtttcagca attagaggaa gaaatgcgct 1737721 ttgtttacgt ttccaaaccg aaaacgataa tggggattcc tgtggaagtt tcagatcagg 1737781 cagaaagctt caagctggaa ttttagtttt cccagactgc taaaaggctc attttgtgtt 1737841 aattatgcaa aatggtcagg ttgatttctt taaaagcatg atgaaatgtt catcatgctt 1737901 ttttattgag aaaaaagacg aacataaaaa ataggtatac gggaaaaata atcctattag 1737961 agagagggga actgacagat ggataacatg atatcaacac ttactgactg gaatgtgtgg 1738021 tttcaagcgt tagtagtatt tctcgttcca tatgtaatct ataaagtgtt tacttggatt 1738081 catgtataag aaggtgcaat gatgaggtgg cggaacaatc agtacaaaac acagaagcag 1738141 cataaatcag attattcgac agctgaaaag caggatcagg atgtgttaac cggtaacatc 1738201 ggatacgact tagaacatgt aaaaagaaaa ataggacata acggggacgt tcatttccgt 1738261 gagcttgaaa tcactcaatt acatgtgaaa gcggcattga tctttgttga aggactgtct 1738321 gatcaggact tgattaataa aggactatca gtgttagtca tgaatcaacc taatcaggta 1738381 agcgatgaaa tttctcaatc cggcaaaggt attttaactt cgaaacagat aaaaaatcaa 1738441 atcgtatcaa tcggtgatgt catagattca gagaaaatca gtgatatcgt gttgaatgtt 1738501 ttcatgggtt cgacagcgct tctcatcgat ggaataccgc aggcctttct tctgggaact 1738561 gtaaaaaaac aaaatcgaag tatcgaggag ccgctttcag aagcgcttgt cagagggccg 1738621 cgcacaggct ttacagaaga gttgagtacg aatacagctc ttttgagaca gcaaggaaaa 1738681 aatgatcaat taacattgca gagatttgaa gtaggaacac gattaaaaaa ggatttaatt 1738741 atcgcttata tgaatgacat tgcagatcca aaagtagtcg aggaagtaag aaaaagagtg 1738801 agagggattg agatcgatca tttgccggag tcaggctacg ttgaacagtt aattgaggat 1738861 aattatttga gcccgttccc gcaagtacag agtacagaac gtcctgatcg cgtcataagc 1738921 ggattaatgg aaggaagagt agctattctg cttgacggca ctccgtttgc tttgattgtt 1738981 ccagtcactt tcagcatgat gcttcaatcg cctgaagatt attatgaacg gtggttcccg 1739041 agctcgctca tcagattgct gaggttcatc gcagcaatga taacgttatt cgcacccgct 1739101 ttatatatat catttatttc ttttcatcct gggttaattc cgaccaagct ggcgatttca 1739161 atttccggga cgcgccaagg tgttccgttc ccatctctga ttgaagcctt atttatggaa 1739221 gtcgcgattg aaattttaag agaggcgggg cttcgtttgc caaaaccaat tggacccgca 1739281 ataggcatag ttggcggatt aatcatcggg gaagcagctg tgcaggcggg gattgtcagt 1739341 ccaatcatgg tcattgttgt tgcgctcaca gcaatttctt catttgccat cccgcattat 1739401 agcacaggta tagcacttcg gatgcttcgg tttggcgcga tgttttgtgc ggcggtgttt 1739461 ggattgtttg gagtcattat gtattatctg ctgctaagca gccatgtcgt aaagctaaag 1739521 agctttggtg tgccatacgc aagtccggca gtgccctatc acttaaaaga ttggaaagac 1739581 tttgttatca gaatgcctct tttagtcatg aagcgccggc ctaaaatgat gaatacagat 1739641 aatacaaaac gggtgaagtg atgaactcga caggatggtg ataaagtctc atgttcagcc 1739701 caaccagtaa aatcacaacc gctcaggcaa cgattatcat cattaattat atgcttgctg 1739761 ccggagttct tacgctccct cggacagtaa cagaacaaac acaatctcct gatggatgga 1739821 tttcagtttt attaggcggg gtcctagcgg taatagccgg gatgattata gctaaattaa 1739881 gccagcagta tcctaaggag accttttatg aatactcccg acatattgta ggaaaatggc 1739941 tcgggcatct gatcagtatt gtttttatta cttattttct ggcactcggt gcatttgaag 1740001 tcagagtcat gtccgaaatc gtggattttt ttctcctcga agggacacct tcttgggcca 1740061 tcattatgac agttctttgg attgggcttt attcaattac acaaggccta gatccgattg 1740121 cacggctttt tgaaatgatt tttccgatta cggtcatcat ctttttaacg atagccctca 1740181 tgagtttagg catatttgag atcaacaatt tgcgccctgt attaggtgat ggaatcatgc 1740241 cggttcttag aggtgtaaag acaacgaacc tttcatttac atgttcagaa attatgttca 1740301 ttttagtagc atttatgaaa aagccgaaaa atgcggtgaa agcagttgtg atcgggacag 1740361 gcgttgtgac cagtttttat atgattacga tgattatggt catcggtgca ctatcagttg 1740421 agggagttgt gacgagaaca tggccggggc ttgacctgat gagaagtttt gaaatacctg 1740481 gtttaatatt tgaacggttt gaatcatttc tgcttgtgat ttggattatg cagctttttg 1740541 ccacgtttat tatcactttt tatgcagctt ccctgggagt ctcacaagtt tttaaaaaga 1740601 aacccctttc atgtatgttt gggctgcttc ctgttatata tatcctctct tgcatgccga 1740661 aaaatgaaaa tgacgtcttt atattgggcg atacggtcag tcatatcgct ttgtatatat 1740721 ttggcgcttt gccgattttg ctgttagtca tttcgaaatg gaggaaaaga ggtgaaaagt 1740781 aaactaaaac gtcaattgcc tgctatggtc atagtatgtc tgctgatgat ttgcgtaaca 1740841 ggatgctgga gcagtcggga aatagaagat ctgggtctca cattcgctat cgcaattgat 1740901 aaaggaaaag aaacgaacac tgaaaaagag ttaaaagaag agggcgggag ctatccgaaa 1740961 aaagacaaca ttacgctgac ctatcaattt gttaatgaaa aagcggcagg cgcgggcaca 1741021 agcgggggag gcggtagcgg acaaggagcg caaaaagcgt acattaatat aagtgaaaca 1741081 ggggattcat tacagcagat cggaagtgag gttgcattaa gacgggaccg agaagtgttt 1741141 agcccgcatt taaaagttgt tgtcatgagt gaagatgtgc tgcacacatt tcctatcgac 1741201 gaaatgctgg atcaattttt tcgtgataat gaaatcaggc tgagctgtct tgttttatct 1741261 gctaaagggg aagcaagaga cgctctccag ctgaaagaga acggagaaat tccggcattt 1741321 cggctgattg gattaggtga aaatgaacat aaagtttcca gaattcttcc ccctatgaca 1741381 ctcgcgaaac taattggaaa actgcattct ggcagcagct ttttactgca aaatgtggtt 1741441 gcggcgaatg gagcggtcaa gtattccgga gcagctgtaa tcaacggaaa atcgaaaaaa 1741501 atgataggca ccttaaatga atatgaaact gaggggatta catggattag aggagaaggg 1741561 aaaggcggag ttgtcaaaag tcatgataaa aagagccaac agacgttagc gtacgatatc 1741621 aataaaatca aaagcagaat tcagccaatc gtaaaaggga aagatatttc attccatgtc 1741681 gatattgaat cagaaggcga tttggttgaa aactggaaca caaaagaggc gttggacacc 1741741 cagtttatag atcgtctcga aacgactatt gaaaacgagg taaagaaaat agttggtcag 1741801 gtattaaaaa aaattcagca tgattataaa gcagatgttg cgggttttga tgaatctttt 1741861 agacttacat atcctcactt atggaaaagg gtgaaaaata actgggatga caccttcagt 1741921 aaagccgaca tcacatacag tgtgaacgtc acaattactc atttcggcac ggttaaaact 1741981 cagtaatgaa tcccaaggaa gagaaggaaa cctctcttct cttttttatg catttattag 1742041 gataaagata ctttttttgg agagatatac acttttcaaa tcgaccaata tgctaatata 1742101 ggaattgctt gaaatagaag ggagaagggg ctgtgaggca gaaaccgatt tatgtagaaa 1742161 tcgaaatgaa atctgatctg gatacactct gggaatatac acaaaaccca tcactgcata 1742221 aggaatggga tctccggttt tcaaatatta cgtatttgaa tagtcagcca tgcgaaaaac 1742281 agaagtttct ttacgaaaca agggtaggct ttggattaaa ggtgtcaggt acaggagaaa 1742341 ccgtcggtgt tttcaacaaa tgttcatctg aaaggtcttc ttcactggct tttggctctg 1742401 atcatccatt atctctgatt cggcatggaa gcggctactg gaagtatata cagagagaaa 1742461 atgggaaaat gacgttttta acacagtacc aatacaaaac agcctacgga ctgctgggaa 1742521 gatggattga tcgtttatta tttcggccgc tgcttggctg ggcgactgcc tggagctttg 1742581 atgcattaag gctttgggta gagcaaaata aacatccgaa gcgcttcatt cgatctgcta 1742641 tcatctatgt gttcatgtgt ctgtttttca gcctgttttg gttctatcaa ggctttgcag 1742701 gtgttaagac aagcatattg acaggaacag cggagatagg cttagctatt ttgtggctgc 1742761 ttcctttaaa aagaaaatgg atcattcatg gtgtccaggc ttgtattttt gctgggtttg 1742821 cttgtctagg ttccgaaata ttcatgtggg ttctattgag tgtgttttcc gctgcaagcg 1742881 gcgctcttag cctgcagctc cccagtgcca ggcgcacaaa acgaaagaga aagaagtgac 1742941 attgtgagtt cgatttatga aaaatcaatt attaactatc atttgctgca tcccaagctg 1743001 cagaaacggt accaattaga cgggtctcat acattcagcg ggacgggaac gatgtcagaa 1743061 ataagcggag gctcttttct ggttagaatg ctgttaaagc tgggtgtttt tttcagatgc 1743121 ttcttttcag aaagaggcaa agacattcca tttacaatac aaaatagaac ttgtcttttg 1743181 aaatcgcaac atacaggaat agaatggaat cgtacatttt tctttaaagg caaaaaacgt 1743241 ttctttgatg cgttaatgat atatgacgag aaagaaaata gaatacttga tttcttcggc 1743301 aaacctcatc tgctgctgtc tgttttgacg ttcgaggcat ctcttgacgg ctctcttacg 1743361 atcacatcgg gaaagcaatg gctattgata tgcggaaaaa gaatcccgct gccgaaatgg 1743421 ctgaccggta catccgaagt ttgcgaaacg tttgatgaaa aaaagaattg tttcaccatt 1743481 gaagtgcatg tgcaaaatac aattcttggc actcttttct tttataaggg aacgtttcag 1743541 gaggaagaga gagaatcatg aaacgaaatg gcatagtcag tgcgctttgt tttattggat 1743601 ttcttgcagc agaagcaccg gatatttcag tggcagaggc actcgttttg ttatccattc 1743661 tatttttcgt gccgggaatt tttccttttg tttttcgtca atctccggtt cgtgctgctc 1743721 agtttatgga aaacgggcta atccagtgct atcctgtagc cgcattcttt gcggtgctgg 1743781 ctctagtgac ggaggttggg ggtttcgcac ttatctggtg gatgtacaca gtttttaatg 1743841 cattgtatgc gatcctccgc ctttgggaaa caaagataca tagaatcgaa gagacatcag 1743901 ttttgttcgg tcttatttat ttggcgggag gaggattttg gttttttgct tatgctgccc 1743961 atttgcagat catgcaattt ggccctctca tcattttgct gactgctgtc cactttcact 1744021 attctgcttt tctgatcccg atcttcaacg gtttactcgg cagaaccatt agaaaacatc 1744081 ggatgttgta cagttggata acatgggtga ttttgctttc gccccttctt atcgcactgg 1744141 gcatcacata ttcaaaaaca cttgatgtca ttgcggttag catttatatg gcggcgattt 1744201 atcttcatgc atttttggtg ttcacggcag cttttcgcac caagacgggg acatttctta 1744261 ttcggctttc ttccgctgtt ttaatgataa cgattgcttt ctcgatgatt tattcatttg 1744321 gtgtctttcg gcaagaagtt acattgacca tcaatcagat gatttggatt cacggttttg 1744381 tcaacgcgtt tggtgttatc ttgcccgctc tcatagggtg gagaatagag gatgcgaaac 1744441 cttttgatgc agacagtgta aagacattca gccgtatcta cggaaaaaga aagattggag 1744501 aagaattttt agctaacatt caagctgaaa ataacgctcg gtacagcgga cttgtggatg 1744561 atatgggcag cctgcgttca aaagattttt caccagaaaa actggcgccg ctcattcttt 1744621 cgttttatga acaaaccatc gaatacaata ttaaagcaaa agtaacatgg agcacgtggt 1744681 ttcggccgct tgcaattatt tacgaatggt tcagcagaag aatcggccaa atacatcttt 1744741 cgacgaaccc tgactggtat aggatgtaca gcaagataaa aggtgttcat tcgaaaaaag 1744801 acggaaggga aagagtacgt gcctggatta gaacaaatga aaaaaacgaa accattttta 1744861 ccgctcttta ttcagtgtat cgttcaaatg gagaggggta tatgaatatt tctttaccgc 1744921 ttccattcag cagcatgaca ggtattttaa aaccatatca tcatcaggag aagctggttt 1744981 taacaagcag gcggagaaaa agcagagcgg gggatgaggg gatttatctg caaacaagag 1745041 cgggaacttg tccgcttcct ttatctgaaa cctttctgat agaagctgta catgacaaca 1745101 aattaaccgc tgttcatcat atgtggctgt ttggaataaa atttctaact gttcattaca 1745161 gcattacaca tattaaccag cctattgaaa gaacctaaca caaagaagaa gcttcgtctg 1745221 ccagttgtaa tgagatgaac tgttttaaaa ttctgcaccg catcaagaca ggaaaggaag 1745281 ggtttatggt gttttatatc agtttatttc tgattctttg gctggctgct gggtttgcag 1745341 tgggaatgaa acaagtgtat gtcgatcagc tgtttgataa agctgtgatc gaaagactgg 1745401 aaaaagaagc gaatgatcat ggacatgctg accggatgat caaacagcgc gtcctttata 1745461 ttgcagcagt gacagtaagc gggtttattt ctgtttatta tgaaatgaaa acaatcccgc 1745521 aaaggcgaaa cataagaaaa attgaaaaaa acatcatgaa attaaatcaa gcaaaaaaac 1745581 gaagaatgaa gagaaaataa aaagtgcaca ggccaaaggg caggtgcatt tttgttttgt 1745641 atggaaaatg ggggaggtgg tgccagctta cttttcataa attcaaaaat gagaagaaca 1745701 gcgcccgggc taatggtata taatattgtg aatttaacaa aaatttaaca aggaggacga 1745761 gagaattcgt gctaaagcct caaagagacc tacattctgt tgatttggac ttagaggcgg 1745821 agtagatgaa accggccaaa gtatccctgc tccgccgttt gctccattcc ttgaagcatg 1745881 ttgattgtaa catagccaaa cgttttccat caactattaa aattgtaaaa ttattgatga 1745941 tttttatggt gtttactccg atttcttcaa tttatgctga agatgtatat cagaattttg 1746001 aggaattaaa aaacaatgaa gatccttctg attatggcgt tgttacgaaa gaaaccggaa 1746061 gccctgttct tgttttagct attcacggag gaggtattga aggcgggaca agtgaagtag 1746121 cgagagagct cagcaaagag tactcgatgt atttatttga aggcttaaaa tcggcaggaa 1746181 actcagtcct gcacattacg agcacacact ttgatgaacc tcgggccctt aaaatgacgg 1746241 gaaatcatga atatgtcatt tcattacacg ggtacgcaga agaagatcag cagatcgaag 1746301 tcggcggtac agatcgcgta agagcggcag atttagttga gaaattgcag catgccggtt 1746361 ttcctgctgt attgctcaat atggaccatc cgcatgcggg cgttagtccg aataacattg 1746421 caaataaatc aaaaacaggt ttaagtattc agatagaaat gagcacaggg tttcgaaagt 1746481 ctttgttcgg catcttttct ttaaaaagca gagctgttac tcaaaatgag aggttttatg 1746541 agtttacaga agtgatgttc cgttttctca aaaatagcta ctgaaaaata ggaggcgata 1746601 agacagcctc ctattcctta tgcttctctt tcgtttcggg aaacagctcg tccgcggctt 1746661 ccgtttgata ctgcaacgtg ttatctctcg ctgacagttc atttcggaaa ttttcatcaa 1746721 gcacattttt cagtaaatac cgatgaaaaa agtattcaaa aacagtaaga caggcagcgg 1746781 aaaggagagc cgctccaaat ggtgagaaat cgtttcttgt ttgggttaaa acaaataccc 1746841 aaagaataac gaatgaaagg ccaaagtcag ccaatgaagc tgtaatattg tttgttctgg 1746901 gtaagacgag catgtcacca gaaagatagg aaacaaaacc taagaaaagt gcaataaaca 1746961 tcacacttaa aaaggatgcg tgatagactc tgtccaaaat cacatataaa agggcgagag 1747021 tgaaagcaat ctttgaagca agcgcaatga tatgtttcat ttgaccacct aaattgttat 1747081 tttttgaaga aaattcttgg gcgtaaacaa atgataaata atgcaattca aaaccattca 1747141 taatggtcat gttactattt taaacagtcc gtttttgttt acactggtat ttttttcagc 1747201 tgtatgaaac tttcttatga aaaaagtcgt atatgtggat gatcagcttt caagggggga 1747261 atgatttgtg gagataaaag gaatcaatca cttgctattt tcagtttcgc atttggatac 1747321 atcgattgat ttttatcaaa aagtgtttgg tgcaaagctt ttggtaaagg gaagaacaac 1747381 tgcatatttt gatatgaacg gcatctggct agcgcttaat gaagaaccag acatcccgag 1747441 aaatgacatt aagctttctt atacccatat tgcttttaca attgaagatc atgaatttga 1747501 ggagatgtca gctaaattaa aaagacttca tgtcaatatt ctgcctggca gagaacgaga 1747561 tgaacgcgat cgaaaatcaa tttattttac cgaccctgac ggccacaaat ttgaatttca 1747621 taccggaacc cttcaagaca ggcttcgata ttacaaacaa gaaaaaacgc atatgcactt 1747681 ttatgatgaa acggcctttt gatagcacaa ccatatttca tataaggtta aatttaaaga 1747741 agggtgttgg tggagacttt atgtttgggg aaggtttcta cccgacttgt tcaacgatgc 1747801 catatctttt gaactgcaca agtgattggg tgaaggtgaa attgaaatac acattacatt 1747861 acattttata tgaagaaagc gagctgtttt atcaaatgtt gaactaatta aactatgtac 1747921 taaattttca gtatatttca attgctttgc cccttaataa atataaaacc gcatccttcc 1747981 acgacctaaa aaatgaaacg tttttaagaa gatggcgtct aatattctaa atgttcatat 1748041 tttgataaaa gtttcctaaa ggaaagaaaa tttcttgact tcaacaatct tttggtggat 1748101 aattatggtg taaacatgat gttctttttc ctcctattcg ggctcgcacc caaaagtcag 1748161 ggcgagcctg ctttttttga acaacaaacc ccctctccgt aaaggaagag ggggttattt 1748221 tatgcatctg atagatcaat agattaatgg acggttctga acacgccaat cactttccct 1748281 agaatgctga cattctgcaa aatgataggt tccatcgttg ggttctcagg ctgcaagcga 1748341 atgtgggtat cctctttata gaatcgtttt acagttgctt catcatcttc tgtcatcgca 1748401 actacaattt ccccattgtt cgctgtgttt tgctgtttaa cgatgacata gtccttatcg 1748461 agaataccag catctatcat actgtctccc ataatctcca gcataaatac atgctcgtct 1748521 ggaggaacca tgcggtcagg gagcggaaaa tattcttcaa tattttctac tgctgtaata 1748581 ggagatcccg ccgtgacttt cccgatgacc ggtacattaa cgacctggct ttgcggaatg 1748641 tctacttctt catcaagaat ttctattgct cttggttttg tcggatctcg tctgatcagc 1748701 ccttttgttt ccaaacgggc caaatggccg tggacagtag aactggacgc aagcccgaca 1748761 gcctctccga tctctctcac ggaaggcgga tatccttttg atttaacctc tgctttaata 1748821 aaacggagga tatcaagttg cctttttgat agcttcgtca tttttcgcac ctcaaaacgt 1748881 cgattttaag aagattatag catgattttc cttacagtac aaacataggt tcgaaaaaac 1748941 aattgacaga aacgtttgtt cgtatatact gaaattataa aaatgcgaac aaacattcct 1749001 gttggaggtt atgatcatga gtaaagaatc tattattttt gtcggtctgt ttacagtgat 1749061 tttgagcgcg gttatcctta tgctgtcata tacaagcagc ggccaagagc ttaatcagta 1749121 tgttaaaata gaagtccagc aaggcgacac actctggtca attgctgatc aggtagccga 1749181 tacaaaaaag ataaacaaaa atgattttat tgaatgggta gctgataaaa atcaacttca 1749241 aacctctgat atccagccgg gtgatgagtt agtgatccca ttgaaaaaga agcatcagga 1749301 tgcatatgaa ttagcaactg taagatagag aggaaagaga gataaaatga aagcactcat 1749361 ttatgcccgt gtaagcacaa ataaagaaca gcaggaaacg tcattaaagc ggcaggagga 1749421 ggagcttacg gccattgcag cggagaacgg catggaagtg gtcaaagtga tttcagaaaa 1749481 agccagcgga tatgaaatgg atcgggatgg tgtatttgag ctgctcgatg agattaagaa 1749541 cgctgatatt gatgtcattt tggttcagga tgagacaagg ctcggacggg gaaacgcaaa 1749601 aatcgcactg cttcattgta tttatagaga aggtgtgaaa gtctatacaa cggctcatag 1749661 aggtgaactg gagttatcgg aggctgactc aatggtcttg gaaatcgtca gcattgtgga 1749721 agagtatcag cgaaagattc acaacatgaa aatcagacgg ggaatgaaac gtgcagtaaa 1749781 aaacggtttt aaaccgcaaa aaaacttaaa aaaccaacat gggaacagtg gaaaagaaaa 1749841 aatagaggtg ccaatctcag agatcgtccg cctgagagcg aataaactga cgtttgctga 1749901 aatcgcggct accctaagag ggtttggcta tgatgtctct aaagcaaccg ttcaccggcg 1749961 ttttcaggaa tacatagaga atgaagagac tgcagagtga atcagttgta aaactttttt 1750021 tgatctagta ctatatagac aaaatgcaat aaaggagttt aacatgattt caaacgcgaa 1750081 aattgccaga attaatgaac ttgctgccaa agctaaagct ggcgttatta cagaagaaga 1750141 aaaagccgaa cagcaaaagc tccgtcaaga gtacttgaaa ggttttcgtt cttctatgaa 1750201 gaacacgtta aaaagtgtga aaatcattga cccagaaggc aatgatgtta caccagaaaa 1750261 gctaaaaaga gaacaaagaa ataacaaact tcactaatat aagaggaata cggcaatatc 1750321 gtattcctct tttgcatata ctataatcaa aactcttatg tgacaaaatt caacaagttt 1750381 ctctcaaatt taagctgaaa cagttgagaa aaagtcgtca gacatttatg atgtaagggt 1750441 acaacacata aggaagggga tttttatgga tacaattgaa aagaaatcag ttgctaccat 1750501 tcgcacactg tcaatagacg ctattgaaaa agcaaattct ggtcacccag ggatgccgat 1750561 gggagccgct ccaatggcat acacgctgtg gacaaaattt atgaacgtaa gtccggcaaa 1750621 ccctggctgg tttaaccgtg accgttttgt tttatctgct ggacacgggt cagcactatt 1750681 atacagcatg cttcatttaa gcgggtttga tcttagtatt gaagatctta agggattccg 1750741 ccagtggggc agcaaaacac caggacatcc ggaattcgga catactgccg gtgttgatgc 1750801 tacaacaggt ccgcttggcc aaggaattgc catggcagtc ggtatggcaa ttgctgaacg 1750861 ccatttagcg gaaacataca accgcgattc atttaacgta gtcgatcatt atacatacag 1750921 tatttgcggt gatggtgatt taatggaagg tatttcttct gaagccgctt cactcgcagg 1750981 ccatcttcag cttggccgtc tgatcgtact atacgattct aatgacatct ctcttgatgg 1751041 agacctcgac cgttcattct ctgaaaacgt gaaacagcgt tttgaagcaa tgaattggga 1751101 agttctttat gttgaggatg gaaacaatat tgaagaatta acagcggcta tcgaaaaagc 1751161 acgccaaaat gaaaagaaac ctacattaat tgaagtgaaa acgacaatcg gattcggttc 1751221 acctaaccgt gccggtacat ccggtgttca cggtgcgccg cttggtaaag aagaaagcaa 1751281 attaacaaaa gaagcttacg cgtggacata tgaagaagac ttctacgttc cgtcagaagt 1751341 ttatgagcat ttcgctgtag ctgttaaaga atcaggtgag aaaaaagaac aagaatggaa 1751401 tgctcaattc gctaaatata aagaagttta tcctgaactt gctgaacagc ttgaactggc 1751461 aatcaaagga gagcttccga aggactggga tcaagaggtt cctgtgtatg aaaaaggaag 1751521 cagtttggca tcccgtgcat cttccggtga agttctcaac ggacttgcga aaaaaattcc 1751581 tttctttgtc ggaggttctg ctgacctagc gggatcgaac aaaacgacta ttaaaaatgc 1751641 cggtgatttt acagcggttg attactcagg caaaaacttc tggtttggtg tacgtgaatt 1751701 tgcgatgggt gcggccttaa acggtatggc gcttcatggc ggtcttcgtg tattcggcgg 1751761 aactttcttt gtcttctctg attacctgcg tcctgcgatt cgccttgcag cgttaatggg 1751821 ccttcctgtg acatatgtct tcacacatga cagtattgcg gttggtgaag acggtccgac 1751881 gcacgagcct gttgaacagc ttgcttcact ccgtgcgatg cctaaccttt ctttgatccg 1751941 tccagcagac ggcaatgaga cagcagcagc atggaagctt gcagtgcaaa gcactgacca 1752001 cccaacagcg ctagtgctta cacgtcaaaa ccttcctacc atcgatcaaa catctgaaga 1752061 agcattggca ggagtagaaa aaggtgcata tgtcgtttct aaatctaaaa acgaaacacc 1752121 tgacgctctt ctcatcgctt ccggatcaga ggtaggtctt gcaattgaag cgcaggctga 1752181 attggcaaaa gaaaatatcg atgtttctgt tgtcagcatg ccttcaatgg accgttttga 1752241 gaaacaatct gatgaataca aaaacgaagt ccttcctgca gatgtgaaaa aacgtcttgc 1752301 aattgaaatg ggctcatcat ttggatgggg caaatacacg gggcttgaag gtgacgttct 1752361 cggcatagac cgattcggtg catctgctcc tggtgaaacc atcattaacg aatacggctt 1752421 ctcagttccg aacgtagtga atcgagttaa ggcattaatc aataagtaag cttttgaaag 1752481 aggatgagtc aaatcatcct ctttttcttg tttatccgac aaaaatagta ttggctgttt 1752541 aacagtaata gacaattctt tcttttcttc ttttgtataa tagagagcaa atgaaatgct 1752601 gctggaaaag gggatgaaaa gatggaacgt cactactata cgtacctgat caaagaggaa 1752661 tttgccaatc actatttcgg ccgggaatcg gttatgtttg agctgtttca agactatcat 1752721 tggacaagcc ttgaaaagca gcagtatgaa atgacagaga aacagattca atatattaca 1752781 caaccaatcc cgattttaca tatgcatcag cggttaaaaa tgaatttaaa caagacggat 1752841 tacaggcagc tggattatat ttatagaata gctttgccga aagcaaaagg ccacgcgacg 1752901 tttatgatga aggagcacat gatagaaatt gtggcttcgg gagattacga ggcagaaacg 1752961 atattctttg aagtgttaag aaaagtaagc ccttgctttt tagcaatgga tttcaattcg 1753021 aagcgttacg gatggctaaa tccggtgaaa gaaagaaatt ttgtctaaaa ccgaagaaaa 1753081 agagatgtaa atgttgtata atagcttttg gtttagtaca ctttaaacta gacaacatga 1753141 aggaggaaat aaaatgactt tatgggttgg catcctagtg ggcgttgttg cattgctcat 1753201 aggtgttgca ctcgggtttt ttattgctcg taaatatatg atgagctacc tgaaaaagaa 1753261 tccgcctatt aatgaacaaa tgttacgcat gatgatgatg caaatgggaa tgaaaccttc 1753321 tcaaaagaaa atcaatcaaa tgatgaaagc catgaataat caaacgaaat aatacgtaaa 1753381 gattatgata tagagaaaca tggttataaa ataaaaaacc cttatacggg ttttttattt 1753441 tgcaatcatt catcacccgc tactgctcga aggcgctgct tttgatattg tatgagaaga 1753501 tggtcaagct cctgactgag ctctatcgta atatgagatg tcattccgtt cgccatgaca 1753561 atttgcagca gctctgctct ttttttttca atttctttta atagatgctc tctaatcaca 1753621 gggatgtatc ctttcataca ttagatcttc aaagtgaatg tttatattat atccatattt 1753681 atactaattt tcaaatgaga aggagtataa tgtctcaatg tcaaattaaa ttatataagt 1753741 tttttctgaa aatagaaatc cttcaagtga aagtgttaaa aaaatgaaat gattttgtca 1753801 taacttgaag gaatgtcaaa tcatgaaggg atgatgacat gggagacgtg aattattttt 1753861 tgacattcgg agcggggttt ttatccttta tttcgccttg ctgcctgccg ctttacccag 1753921 cttttttgtc atatattaca ggggtcagca tggacgatgt aaaaactgaa aagctgctgc 1753981 tgcagaaaag aagcttgttt catactttgt gttttttgct tggcttttca gtcattttta 1754041 ttgctttagg ctatggaaca tcttttattg gcagcctgtt tagggattat cacgatgcga 1754101 ttcggcaaat tggcgcgttg cttattattt tgttcggttt cattacactc ggtgtgttcc 1754161 ggcctgaggc tatgatgaaa gagcggagaa tccattttaa gcataaacca agcgggtttt 1754221 tagggtcggt cttaatcgga atggcatttg cagctggatg gacaccatgt accggtccga 1754281 tattagctgc tgttatcaca cttgcaggca ccaatccggg ctcagcggtg ccatacatga 1754341 tgttatatgt actcggtttt gcggtaccgt ttcttttatt gtcttttttt atcacaaagc 1754401 tgaagtggat aaggaagaac cagcttttca ttatgaaagc tggtggcgtt ttgatgattg 1754461 tgattggtgt gctgttattc tttaattgga tgagcctgat cattattttg ctgtcagatc 1754521 tttttggagg ctttactggt ttttgacggt aaattacttt cgtactacta ctaatccttt 1754581 tgtttttggt acaataagac tattatctgt ggaaatcgat tgttggaggg gaatatgaca 1754641 agagttttag ttgtagacga cgccaagttc atgagagtga aaatcagaga gatcttggaa 1754701 gaggcaaatt acataatcgc aggcgaagcg gcggacggtg aacaagcagc tgacctgtat 1754761 aaaaaactgc gcccggacct tgtgacaatg gatattacaa tgccggtgaa aaacggcata 1754821 aaagcgcttc gtgatatctt aacctttgat cctaaagcga aggtcatcat gtgcaccgcc 1754881 atgcgccagc aaagaattgt aacggaagca attgagctgg gggcaaagga ttttattgtt 1754941 aagccgtttg aggaaacaaa agtgctggaa gctgtaagcc gcgttatggg acattaaagt 1755001 catttctttt caaaatggtt ttttttattg ttttggagta tagtatatag tatcaacact 1755061 ccgagaaaca aaggaatgat aagtatgatg attatagttt catcaattat tgctgtgtta 1755121 atggctgtag ctgtgatggt ggtcagaata aagtcctctg acaagcctgt ttcaccaaaa 1755181 aaaatcattc ttccgccgat ttttatgagt acgggagcgt taatgttttt atttccggta 1755241 ttttgggtaa ctggagcaga gtttttggaa gcattcactt taggtgtgat tttctctatt 1755301 tttctaatca aaacttctaa gttcgaaatt aaaaataatg aaatttacat gaaacgctct 1755361 aaagcatttg tttttatatt agtcggtctt ttggtgatca gaatcgtgat gaaatcgatc 1755421 ttgagcacat caattgatta tggtgcactg agcggaatgt tttggattct ggctttcggt 1755481 atgattgtgc cttggagaat cgccatgtat ttatcatatc gaaaacttca taacgagctg 1755541 cagtcatcta atattcaaat gaattaaaaa acctttcctc ttgtcaggaa aggtttttta 1755601 tttgagaagg gtctgataag gttccaaatc gatttttttg tcccgcagat gcctttttaa 1755661 gaaggtatgg tctcttttag gagttgcgag aatatagcct ttgatcataa gttgctgatc 1755721 aatctttgct accttttctt ttaatgcaag ctcaccgatt ttgcctgcga ttttagcttt 1755781 tgctgcatct ctgaacagct ctggcacggg cgcagtcaat tcatctagaa actgtttgtt 1755841 ttcatcgttc cataaatgtc tgctgttttc aatatagtaa tcctgccaat caagctctga 1755901 tctgccgtcc tcttttggta aacgctttaa aaactttcga aacatgaaaa aaccgccgat 1755961 tgataataag actaccatca tgattaccca aaacagaata aaccataaaa accatccttc 1756021 cagcatcaat cattccccct tattctaacc atattgtata cgaagagaga ttagaagaac 1756081 acagtaaaaa aagaatagaa aaaagtgata gacgtctagt caaaagagat agtagatcat 1756141 attctattgt atagtgaatc tgctatttgg ccatgggaga gtcactagag ggtatttgac 1756201 gataaatgga cggaaaaaaa gtcactttca taatagggga tgaaagtgac tttttatgtt 1756261 tagctgagag gaaattgaag agaaaaagaa gagccatctt ctgtttcttt attgacggcg 1756321 actgtgagta tttgattttc gcattcgact tgaatgtttt tgtcattaaa ataaaaagga 1756381 agcatcattt gtttttcaaa agtctgtcct gacgatttga cagttaagat gaactcgcat 1756441 ccagaaaggg taactgttac ttgtgtaggc tgtaaaaaag tcagatccgc ttctataata 1756501 tactgctgac ttgtttcata taaatcaata ggcaatgttt cgtcgtacca ggcgaagggg 1756561 tcttcaaaaa attgccgaag ccattcatcc atactatcga aatcattcgc atcgttgcgt 1756621 tttgaatggt tcatggaagc attcctccac atatcaacct tgctttacat catatgcggt 1756681 ggattataaa tgggtgaacg cataaaaaaa cagacactaa ggtctgcttt tcttacatat 1756741 catggcttga gttgtgcttt tgtcttgtat ggtttcggtt ttttactttt ttgcttccgc 1756801 ttagaggctc gggttggccg ggattgtgtc ctttaggggc gtttttatgc atatctttac 1756861 ttgtattctt attggtcata aaatgagaac ctccttaaaa gagttcggtg ttattgattg 1756921 gtttttcttt ttttgttatt ttggcgttct gcttcagtca gtacaagctg gtcgttttca 1756981 atatagccgg cgcctttgcc ttggcttttt gcgtcattca ttccgttaat gacgtgattc 1757041 gcttttcttt tgaccatcat tatcacctca atcataatat ggcttctttt attgtgttat 1757101 atgagagagc gtaaacagta aaaattaccg gtacattttt ctcataagtc gaacttattg 1757161 tatttaataa aaacattgat atttacttat gtatgatttt gttttaatat gaaattgtga 1757221 gaaaattgtg atggaatgta atgttcatct gagaatgatc tgatctgaag ggggattttg 1757281 gagaatggca aacgagcaaa aaactgcagc aaaagacgtt ttccaagcga gaaaaacgtt 1757341 tactacaaat gggaaaacat atcattacta ctctttaaaa gcgttagaag attcaggtat 1757401 aggaaaggtt tcgaagcttc cttattccat caaagttctt ttagaatcag tattgcgtca 1757461 agttgacggc ttcgttatca aaaaagaaca cgtggaaaat ttggcaaaat ggggaactgc 1757521 cgaattaaag gatatcgacg ttccgttcaa accgtctcgt gttattttac aagacttcac 1757581 aggggttccg gcagtagtag atctggcttc actgcgtaaa gcaatggcag ctgtcggcgg 1757641 agatcctgat aaaatcaacc ctgaaattcc tgttgatctc gttatcgatc actctgtaca 1757701 ggtagataaa gcgggtacag aagatgcatt agcagtaaat atggacttgg aattcgaaag 1757761 aaatgcagag cgctacaaat ttttaagctg ggcaaagaaa gcgtttaaca attatcaggc 1757821 agtaccgcct gcaacaggta ttgtgcacca ggtcaacctt gagttcttgg caagtgttgt 1757881 ccatgccatt gaagaagacg gcgagcttgt aacgtatcct gatacgcttg tcggaacaga 1757941 ctcacacaca acaatgatta acggtatcgg tgttctcggc tggggtgtcg gtggaattga 1758001 agctgaagcg ggaatgcttg gacagccttc ttacttccca gttccagagg taatcggcgc 1758061 gaaacttgtc ggcaagcttc caaacggaac aacagctact gacttggcgt taaaagtaac 1758121 acaagtgctg cgtgaaaaag gcgttgtcgg taaatttgtt gaattcttcg gaccgggaat 1758181 tgctgaactg ccgcttgcag atcgcgcaac aattgcgaat atggctccgg aatacggtgc 1758241 tacatgcgga ttcttcccag tagatgaaga agcgcttaac tacctgcgcc tgactggccg 1758301 tgatcctgaa catattgatg ttgttgaagc atactgcaga agcaatggct tgttctacac 1758361 tccagatgcg gaagaccctc aatttactga tgtggttgaa attgacctgt ctcaaattga 1758421 agcaaactta tcgggtccaa agcgtcctca ggatttgatc ccgctatctg ctatgcagga 1758481 aacgtttaaa aagcaattag tcagccctgc aggtaaccaa ggattcggtt taaatgctga 1758541 ggaagaaaat aaagaaatta agtttaaact ccttaacggc gaagaaacag ttatgaaaac 1758601 gggtgcgatc gccattgctg cgattacaag ctgtacaaat acatcaaacc catacgtgct 1758661 gatcggcgcc ggactggtag cgaaaaaagc ggttgagtta gggcttaagg tgcctaatta 1758721 cgtgaaaacg tcacttgcac cgggttctaa agttgttaca ggatatcttg tgaattcagg 1758781 ccttcttcca tacatgaaag agcttggctt taacctcgtt gggtacggct gtacaacatg 1758841 tatcgggaac tcaggtccgc tttcaccgga aatcgaagaa gcggttgcga aaaatgatct 1758901 tctgattacg tctgtccttt ccggaaaccg taactttgaa ggacgtattc acccgcttgt 1758961 taaaggcaac tatcttgctt caccgccgct tgttgtggca tatgcgctgg ctggaacggt 1759021 aaacattaac ttaaaaaccg atccaatcgg tgtgggcaag gatggtcaaa acgtatactt 1759081 taatgatatt tggccgtcaa tggacgaaat caatgcactt gttaagcaaa ctgttacgcc 1759141 agagctattc cgcaaagagt atgaaacagt atttgatgac aacaagcgct ggaacgaaat 1759201 tgaaacaaca gatgaagctt tatataaatg ggataacgat tcaacttaca tccaaaaccc 1759261 accattcttt gaagagatgt ctgttgagcc aggcaaggtt gagccattaa aaggactgcg 1759321 tgttgtcggt aaattcggcg attcagtcac aactgaccat atttctcctg cgggggcaat 1759381 cggaaaagat acgcctgccg gaaagtattt gcaagaaaaa ggtgtttcac ctcgtgactt 1759441 taactcctac ggctcccgcc gtggaaacca tgaagtcatg atgagaggaa catttgccaa 1759501 cattcgcatc aaaaaccaaa tcgcaccggg tacagaaggc ggatttacga cgtactggcc 1759561 gactggtgaa gtaacatcca tctatgatgc atgcatgaaa tacaaagaag ataaaaccgg 1759621 tcttgtcgta ttagcaggaa aagactatgg tatgggatct tcacgtgact gggctgcaaa 1759681 aggaacaaac cttctcggca tcagaacggt cattgcagag agcttcgaaa gaattcacag 1759741 aagcaatctt gtattcatgg gtgtgctgcc gcttcagttt aaacaaggtg aaaatgcgga 1759801 tacactcggc ttaacgggta aagaagtcat cgaggtagat gttgatgaaa cagttcgtcc 1759861 tcgtgacctt gtgactgtaa gagcaatcaa tgaagacggc aatgtaacaa cttttgaagc 1759921 agtcgtccgc tttgatagtg aagttgaaat tgattactac cgccatggcg gcatccttca 1759981 aatggtgctt cgtgaaaaaa tgaagcagtc ctgatgaatc aataggaaga gaaggcattt 1760041 cgctttctct tctttttatg acacaatgtg ctgcggaggt ggcatatgct gaaaaaatgg 1760101 ctcgcaggga tcctgcttat catgctagtc ggttatacgg gatggaattt atatcaaaca 1760161 tacagcaaaa aagaagtcgg aattcaagag gggcaacaag cacctgattt ttctttgaaa 1760221 acgctatcag gagagaaaag ctctttacag gatgcaaaag gcaaaaaagt gctgctcaat 1760281 ttttgggcaa cttggtgtaa gccgtgccgt caggaaatgc ctgcgatgga aaagctgcaa 1760341 aaagagtacg ccgacaaact tgcggttgtt gcggtaaatt tcacttcagc tgagaaaagt 1760401 gagaaacagg tccgagcgtt tgctgatact tatgacttaa cgttccccat tctgattgat 1760461 aaaaaaggga tcaatgctga ctataacgtg atgtcatatc caacgacata tatcttagat 1760521 gaaaaaggtg ttatccaaga catacatgtt ggcaccatga caaaaaaaga aatggaacaa 1760581 aaactggatc ttgattagat tcagtttttt ttatactcaa atatgcttac aagttttcag 1760641 aattggaaaa aataaaagaa tatgcggagg tgagaagcgt gaagaagatg agaaaacgtt 1760701 cttttcatga gctcgtcatg gaaaacaaaa aagagctgat gaccaataca gagtatttaa 1760761 atcagcttga ggaaaagctt gaacagcgat ttaagcaaaa ataaccttta atttgtattc 1760821 atgtttaccc ctccttttga gaaacctatc tgttgaggag ggataaacat gggaaacaac 1760881 aagaaaaacg gtcagcctca atatgctcca agccacttgg gtacaaagcc tgtaaaatat 1760941 aaagccaata aaggggaaaa aatgcatgat acttcaggac agcggccgat tatcatgcag 1761001 acaaaaggcg agtagcgaaa attcgagttt atttctagga ggtacatccg aatgacaaag 1761061 aaccaaaatc aatatcagca gcctaatcct gatgatcgtt ctgacaatgt ggaaaaattg 1761121 caggatatgg ttcaaaatac aattgaaaat atagaagaag cagaagcatc aatggagttt 1761181 gcttcaggag aagataaaca gcgtatcaaa gaaaaaaatg caaggcgcga acagagcatt 1761241 gaagcgtttc gtaatgaaat acaggacgaa tctgcagcga gacaaaacgg ataccgttct 1761301 taaaaaacca gggaaacctg gtttttttct ttctgatttg attatggtaa aatggggcta 1761361 aattgacgtt aagggagcag agtaatcttg catgtatcaa aaaaagaaat agaagtgcgt 1761421 tatgcagaaa cagatcaaat ggggattgtc tatcacgcaa attatcttgt gtggatggag 1761481 gtcggcagaa cggccttgat taaggactta ggctttttat atagtgatat ggaaaaaaaa 1761541 ggcgttctgt ccccagtcgt tgatatcaat atttcctata aaaagccgct tcattacgga 1761601 gaaaccgcgg ttgtacatac atggatagag gactataacg gatttaaaac cgtctatggt 1761661 taccacattt ataatccggc cggtgagctt tccatcaaag ccacctcatc tcatatttgt 1761721 gtggataaag aaagctttaa gccaattcaa ttccgcaaag cttttcctga ttggcacaca 1761781 gcatatgaaa aggccaaaaa atagggaagt gaacgggata tggcgtttgg tgtgaaacgg 1761841 gaggaactta accggtggaa acaagcagtg aaaagaggag aaatcgcatt tttaacacat 1761901 tactggctgg atgaccgatt tccagaagca aagaccgtga caaaagccgg ctgtgcagac 1761961 attgataagc tggttcagtg gggagcggcg tacgggttaa aaaaagaatg gatccataag 1762021 aaaagtgaat ttccccactt tgatctgctg ggggaaacac aaaaatatat tttggaacaa 1762081 gaaaacctaa ccgatcatct tatacgattt catttgtaaa aaaagaacgc acatgaagtg 1762141 cgttcttttt tattggtatt caaaaaccgg ttcatcagcg tcttctgaat agctgacgag 1762201 aaggtcgtgg ttatcaaagt accataaatc actttcttca ataaagaagg taatgccatc 1762261 agcttctgca gtgactccag cctcttgtgg ggcatctttc gctacaccga gagaaaaacc 1762321 cttttgaacg ttgctgcagc ctccatagcg gacgaaaaag cgaacctggt ctccgctttc 1762381 caaatcgagt tcttctttat accagttcaa tgcgtcttcg ttaattgtca tattcataac 1762441 agaacacccc tttgttcttc atttgaattt tctctattat aaacgtatta ggctattctg 1762501 tgtcaaaaga gaagtttttt aagcttataa ccattttact ttaggttctg ttttattgat 1762561 aattcgttta atgttcgctc ggtgtctgta tatcacaaaa atagtgagca gggtaacgac 1762621 aatcaataaa tacgtatcat ggacaaagaa actatatata acagtataga tccctgttaa 1762681 catcgatgag agagaaacaa atttagtcaa gtataaaaag atgaagaata ccgcaaccat 1762741 cgtgataaat aacaggggtg cgtaaaatag caaaacgcct cctgatgtcg ccacggcttt 1762801 accgccttta aatttggcga agatgggaaa cacgtggcct aaaaccgcaa agactcctgc 1762861 aagaagcggg tgaatatcaa catgcatgag aaaaggcaat gcagttgcca gtgtcccttt 1762921 caaaatatct ccggctatga cgaccgaacc agcttttaca cccaatgtac ggaatgcatt 1762981 ggtagcgcct aagttgccgc ttccgtgctc ccgaatatca attcctttgg caagcttgcc 1763041 cacaattaag ccagatggaa tgctgcctat caagtaggcc aaaataatca ataaagcaat 1763101 taacatctac atttctcctt tttcaaattc ccttcttttt attttaacat gagatgtcat 1763161 gatctgatga taagtttttt tgtaaagttt gcttacaaat caaatcaaac atgcatcata 1763221 ttttgatttc tcctgttttg atcgtgtaaa ataagtgaaa aaggagtgac acacgatgca 1763281 aaacccttct aaagcggaaa ttaaagagat tcttcaaaga agcaaacgta tagcggtagt 1763341 agggctttca gaccgtccgg atagaacgtc acatatggtt tcaaaagcaa tgcaggacgc 1763401 gggttatgaa attatccctg tgaaccctac aattgatgag gcgctaggtg tcaaagccgt 1763461 ttcatcttta aaagagatag acggtccgat tgacatcgta aatgtattcc ggcgctcaga 1763521 acagcttcct ggagtggcgg aagagttttt agagacagat gcgccagtat tttgggcaca 1763581 gcaagggcta gttaatgagg aagcatacca gatgctaaaa gaaaaaggca gaacggttat 1763641 catggatctg tgcataaaag tggcacacgc tgtaacaaaa taggtgcaga actgcaaaaa 1763701 tccttgtaaa ttcaaggatt tttgcttttt aattttaaga tattgtttgc gtattacggt 1763761 gaaacagata caataaagct tgaacagctt tttttgaata ccttgtccag ctgggtttcg 1763821 gccgttcgat ttgcgaaggt ctgctgcttt atatataata aacaaacata cgttctcata 1763881 gtgtaaaaac agcactagcc gatgttttga gaagaactga ttcgttagct ctatgttgcg 1763941 attgcaaaca tattggttat aatgaggagt ccaaggcagt actggctcga ggcgaggttt 1764001 ataaaaaata tcttatatac aaatgatgtg taacactgaa aagagaaaga caatgttagt 1764061 ttttgaaagg ggtttgtacg tttggctaga aaacagcaat ttgattacaa cgaagatgcc 1764121 atacaggtgc tcgaaggcct tgaggctgtc aggaaaaggc cgggtatgta tattggctct 1764181 actgacgcgc ggggtttgca ccacttggtt tatgaaattg tagataactc tgtcgacgag 1764241 gtgcttgccg gccatggaga tcacataatc gtcaaaatac ataaagacaa tagtatttct 1764301 gtacaggata gaggccgcgg catgccgacc ggaatgcata agctcggcaa accaacccct 1764361 gaagtgattt taacggtgct tcatgccgga gggaaattcg gccaaggcgg ctataagaca 1764421 agcggcgggc tccacggagt tggtgcatca gtcgtgaatg ctttatctga atggctgacg 1764481 gttaccattg agcgggacgg ttttgtctat cagcagcgat ttgaaaatgg aggaaaaccg 1764541 gttacatctc tcgaaaagat cggcaaaaca aaaaagacgg gaactcttac acactttaag 1764601 ccagatccaa cgatgttcag cacaaccact tataattttg aaacgctctc tgagcgctta 1764661 agagagtctg cgtttttgtt aaaaggactg aaaattgagc tgattgatga acgcaatgac 1764721 cagcgtgagg tcttttatta tgaaaacggc atagaagcgt ttgttgctta cttaaatgaa 1764781 gaaaaagacg tcttgtctga agtggtctcg tttgagggtg agcatcattc tatagaagtg 1764841 gactttgcgt tccagtttaa cgatggttat tctgaaaata ttttgtcgtt tgtcaacaat 1764901 gtcagaacaa aagacggcgg gacgcatgag tcaggtgcaa aaactgcgat gacgcgtgct 1764961 tttaatgaat atgcgcgaaa agtggctttg ctgaaagaaa aggataagaa ccttgaaggc 1765021 accgatataa gggaagggct ttcagccatt atttctgtcc gcattcctga ggagcttctt 1765081 caatttgagg gacaaacaaa aggaaagctc ggtaccagtg aagcaagatc agcggtggat 1765141 gcgattgttt cagagcagct tgcttacttt ttagaggaaa atcgggacac cgcaacgctt 1765201 cttgtcaaaa aagcaatcaa ggcgagccag gcgcgcgaag cggcacgcaa agcccgtgaa 1765261 gaagcaagaa gcggcaaaaa acgaaaaaaa tcagaagcga ctttaagcgg aaagctgacg 1765321 cctgcgggtt caagaaaccc ggcaaaaaat gaattgtatc tcgttgaggg agattcagca 1765381 ggcgggtcag ccaagcaggg acgagaccgc agattccagg cggttctgcc tttacgcggt 1765441 aaagtcatta atacagaaaa agctaagctt gctgatatct ttaaaaatga agagatcaat 1765501 acgatcattc atgcgatcgg cgggggagtc ggggcagatt tctcaatcga tgacatcaac 1765561 tacgacaaaa tcatcattat gaccgatgcc gatactgacg gcgcccatat tcaagtgctg 1765621 cttcttacct ttttctatcg ctatatgaaa ccgctcattg agcatggcaa ggtgttcatt 1765681 gcgctgccac ctttatataa ggtcagtaaa ggaagcggga aaaaggaaat cattgaatat 1765741 gcatggtctg atgaagagat gggggatgtc ctgaaaaaag tcggcaaagg ctataccatt 1765801 caacgatata agggtcttgg agagatgaac gcagaccagc tgtgggaaac gacgatgaat 1765861 ccggagtccc gcacacttgt tagggtcaaa attgacgatg cggcacgtgt agagagacgt 1765921 gtgacgacgt taatgggaga caaagtagag ccgcgcagaa agtggattga gaaaaacgtc 1765981 gctttcggct tagatgaaga aagcaatatt ttagaaaatg aaaacttatc ggtcgctgag 1766041 gaggtttaat gattgtcaca gccagaatta tttcatgatt taccattaga agaggtgatc 1766101 ggcgaccgtt ttggacgcta cagtaaatat attattcaag acagggcgct gcccgatgcg 1766161 agagacggat taaagccggt acagcgcaga attctgtatg caatgcatac agatggaaac 1766221 acgtttgata aaaacttcag aaaagcggcc aaaacggtcg gtaacgtcat cggtaactat 1766281 catccgcacg gtgacagctc ggtttatgaa gcaatggtgc ggatgagcca ggattggaaa 1766341 gttcgtaatg tgttaatcga aatgcatgga aacaatggaa gcatcgacgg agatcccccg 1766401 gcagccatgc gttatacaga ggcacgatta tctccgatag catctgagct tcttcgggat 1766461 attgacaaaa acacggttga atttgtgccg aacttcgatg atacaagcaa ggagcctgtc 1766521 gtactcccgg cgatgtttcc taacctattg gtcaacggat ctaccgggat ttcagcagga 1766581 tacgcgaccg acattccccc tcatcatctg ggagaagtca ttgatgctgt cattaagcgt 1766641 attcaaatgc cttcttgctc tgttgacgaa ctcatggaag ttattaaagg gcctgatttt 1766701 ccgacaggcg gtattattca gggcgttgac gggataagaa aagcttacga aaccggaaaa 1766761 ggaaaaatca ttatccgcgg aaaggctgaa attgaaacaa tcagaggcgg acgagaacaa 1766821 attgtcatta ctgaaattcc atttgaagta aataaagcaa accttgtaaa aaaaatggac 1766881 gagttccgta ttgataaaaa ggttgaaggc atctcagagg ttcgtgatga aacggatcga 1766941 acagggctga gagtggtcat tgaactgaaa aaagaagctg atgccaaagg cattttgaat 1767001 ttcttatata aaaatactga tttgcagatc acatataact tcaatatggt ggctatccat 1767061 aaccgccgtc cgatgctgat gagcctgccg tctattttgg atgcatatat cggacaccaa 1767121 aaggaagttg tcacaaaccg gtccgtttac gagcttcaaa aagcaaaaga cagacatcat 1767181 atcgtagaag ggctcatgaa agctttgtct attttggatg aagtgattgc aacaatccgt 1767241 tcttctagcg ataaacgtga cgctaaaaac aatttgatcg cgaaatatga atttacagag 1767301 cctcaggctg aagccatcgt gtcattgcag ctatatcgtt taaccaatac cgatatcaca 1767361 gcgcttaagg aagaggcaga agagctcggt aaaaaaattg aagagctcga atctattctg 1767421 agcaatgata aaaaactgct aaaagtgatt acaaacagct taaaagcact gaaaaagaaa 1767481 tatgcagata cgagacgctc cgtgattgaa gaaaaaattg aagaaattaa aatcaatctc 1767541 gaagtcatgg ttgcatctga ggatgtatat gtaaccgtta cgaaggatgg ttacctaaaa 1767601 cggacgagcc agcgctcatt tgccgcttcc aacggtcagg acttcggaat gaaagatacg 1767661 gacaggatgc tgcatcagtt tgaaatgaat acgacagacg tgctgctgct ctttacgaac 1767721 aaaggaagct acatctattg tcctgttcac cagctgcctg atatcagatg gaaggacatg 1767781 ggccagcatt tttcaaatct aatcactatt gaccgtgatg aaacgattgt aaaggctata 1767841 ccgataaaag aatttgatcc gtcggcatat cttctattct ttacgaaaaa cggtatggtg 1767901 aaaaagacag agctcactca ttataaagca cagcgttatt ctaaggcact tgtagcctta 1767961 aatctgaagg gtgaagatga actgattgat gtacatgtaa caaatgggga aagccagatc 1768021 tttatggcca ctcacttagg gtatggtcta tggtttggag aagacgaagt gaatgtagtt 1768081 ggcgcgcgtg cggcaggtgt caaagggatt aacttaaaag aggatgactt tgttgtctcc 1768141 ggtgagattc ttcagcaatc tgattcaatt gtcttgttca cacagcgggg agcggttaaa 1768201 cgcatgagtc tttctgagtt cgagaagaca tcccgtgcaa aacgcggtgt cgtaatgcta 1768261 agggaactga aaaagaatcc tcaccgtgtt gtagcactgt tcgcttgcgg tcttgaacag 1768321 cgactaatgg cagaaacaga aaaaggcgac agaaaagaac tgcagacaaa agagttgcgg 1768381 acaaacgaca gatacagcaa tggctctttc ttttttgatg aagaggaatc aggcaaggtt 1768441 acagctgttt ggcgccttca tacagaacaa taataaaaaa cccgctcata ctatatgagc 1768501 gggtttcgtt tgttttttat cagctttcat ggttggtgaa tagatctgtt acagcatgaa 1768561 tgacttcaat cccctgccat acaaataaat tcagcgctgt gaaagaaaat aagcctaaaa 1768621 tcaccattct taagataaac aacatgttta acagcctcct catattttcg ttacataatc 1768681 gggtgatgtt gaacatgaag tttgccgaaa taagacgatt gataaaattt ggccagtata 1768741 aagctttttt tccgctgacg tctgcgggag tatcccgtac ttttgctttc agcggtcagc 1768801 agcagaacag ccattgccca taaagcggtc agcgtaaatg cccctgtgat ggatttcttc 1768861 tcatcatcag cattttggcc ggctttcatc tcatgcattt cctgctggtc ggctacggct 1768921 ttataatgat ggccgatatc aaaggcgtgg ggaattgaga acaaatgaaa actggcaatc 1768981 gccaagaata agatggatgc tttcaatatc gttacttttt tcaaatgatc tccccctcct 1769041 ttaatattac tgaatatttt tataataata ccccaatcca tcctaaaagt aaacctgatt 1769101 tattaaattt aaaaataaat ttaactttgt taagtatata tctttttgct tatttttgaa 1769161 agagaaaact tcttttatta gcgtatgtat acccggttta tggtgtgaat aaaaacatat 1769221 tttaaatgat atgttgttta ggatttatta ctttatttat gtgtaaatca aagagaaagg 1769281 caagagaatg ggaagaaatg attacattgt taatagggta ctcttttttt aaagccagtt 1769341 tgcaaggaat gtttttattc gtaggaaaat aatagagaag gggtcgacag agtaacatct 1769401 ggctatgaca atattcttct cgaaaaaact tcctaattcg tcatattgtg atataataaa 1769461 actcgttatg ttaaaaaatc taacatcaaa atcgaattcg tattgaattg atgaaaacgg 1769521 gaggtaaata tggagtcttt tttcaatagt ttgattaata ttccaagtga tttcatctgg 1769581 aaatacctat tttatatttt aatagggctt ggattatttt ttaccatacg ttttggtttt 1769641 atccaattcc gttattttat tgaaatgttc agaatagtag gggagaagcc ggaaggaaat 1769701 aaaggtgttt catctatgca ggcattcttt atttcggccg catcccgagt cggcacaggg 1769761 aatttgactg gtgtagcctt agcaattgcg acaggcggac caggcgctgt attttggatg 1769821 tgggtagtgg ctgcagtagg catggcttca agctttgtcg aaagtacatt agcacagctt 1769881 tataaggtaa gagacgggga ggatttccgc ggagggccgg cctactatat tcaaaagggt 1769941 cttggtgcca gatggcttgg catcgttttt gcaatcttaa ttaccgtctc attcggcttg 1770001 atttttaacg ctgttcaaac aaatacaatt gctggagcat tggatggcgc attccatgta 1770061 aataaaatag ttgtagccat agttctggcg gttttaactg cgtttatcat tttcggcggt 1770121 ttaaaacgtg ttgtcgctgt ttcacagcta attgtgccgg ttatggcagg catttatatt 1770181 cttatcgctt tatttgttgt catcacgaat attacggctt tccctggcgt tatcgctaca 1770241 attgttaaaa atgctttagg ttttgaacaa gtcgtcggcg gcggaatagg cggcatcatc 1770301 gttatcggtg cgcaacgcgg acttttttca aacgaagcag gaatggggag cgcaccaaac 1770361 gcggctgcga cggctcatgt atcccatccg gcaaagcaag gctttattca aacattaggc 1770421 gtatttttcg atacatttat catatgtacg tccacagcat ttattatttt gctgtacagt 1770481 gtaacgccaa aaggcgacgg catccaagtc acacaggctg ctcttaacca tcacattgga 1770541 ggctgggcgc cgactttcat cgcagtcgca atgttcttgt ttgcattcag ttcagttgtc 1770601 ggcaactatt attatggcga gacaaacatt gaatttatta aaacaagcaa aacatggctg 1770661 aacatttacc gtatcgctgt tattgctatg gttgtgtatg gatctttatc aggcttccaa 1770721 atcgtttggg atatggcgga cctctttatg ggtatcatgg cgctgatcaa cttaattgtg 1770781 attgcgctgc tgtcaaacgt tgcttacaaa gtgtataaag attacgcgaa acagcgtaag 1770841 caaggacttg atcctgtgtt taaagcgaaa aacatcccag ggctgaaaaa cgctgaaaca 1770901 tgggaagatg agaaacaaga agcataatat aaatataaaa caaagctgca ttcaatagtt 1770961 gaatgcagct ttttcattat tggaaataaa tttaattttt cgactcgaat gaaaaatgac 1771021 gtgtaaagtc ccaattcagt ccagttttct ttgttctata tgtgtcatgt gtgtcttatt 1771081 cattggaggt agagcaaatt gacaggcttt taaacctccc caaaacaaga aattaggttg 1771141 atagacaatc atgagaaaga tttttacaat gagttcgtgc tcataagaag tgtagagcca 1771201 aaatgatgcg aaggaggaaa agatcagata tgaaacggtc aatctctatt tttattacgt 1771261 gtttattgat tacgttattg acaatgggcg gcatgatagc ttcgccggca tcagcagcag 1771321 ggacaaaaac gccagtagcc aagaatggcc agcttagcat aaaaggtaca cagctcgtta 1771381 accgagacgg taaagcggta cagctgaagg ggatcagttc acacggattg caatggtatg 1771441 gagaatatgt caataaagac agcttaaaat ggctgagaga tgattggggt atcaccgttt 1771501 tccgtgcagc gatgtatacg gcagatggcg gttatattga caacccgtcc gtgaaaaata 1771561 aagtaaaaga agcggttgaa gcggcaaaag agcttgggat atatgtcatc attgactggc 1771621 atatcttaaa tgacggtaat ccaaaccaaa ataaagagaa ggcaaaagaa ttcttcaagg 1771681 aaatgtcaag cctttacgga aacacgccaa acgtcattta tgaaattgca aacgaaccaa 1771741 acggtgatgt gaactggaag cgtgatatta aaccatatgc ggaagaagtg atttcagtta 1771801 tccgcaaaaa tgatccagac aacatcatca ttgtcggaac cggtacatgg agccaggatg 1771861 tgaatgatgc tgccgatgac cagctaaaag atgcaaacgt tatgtacgca cttcattttt 1771921 atgccggcac acacggccaa tttttacggg ataaagcaaa ctatgcactc agcaaaggag 1771981 cacctatttt tgtgacagag tggggaacaa gcgacgcgtc tggcaatggc ggtgtattcc 1772041 ttgatcaatc gagggaatgg ctgaaatatc tcgacagcaa gaccattagc tgggtgaact 1772101 ggaatctttc tgataagcag gaatcatcct cagctttaaa gccgggggca tctaaaacag 1772161 gcggctggcg gttgtcagat ttatctgctt caggaacatt cgttagagaa aacattctcg 1772221 gcaccaaaga ttcgacgaag gacattcctg aaacgccatc aaaagataaa cccacacagg 1772281 aaaatggtat ttctgtacag tacagagcag gggatgggag tatgaacagc aaccaaatcc 1772341 gtccgcagct tcaaataaaa aataacggca ataccacggt tgatttaaaa gatgtcactg 1772401 cccgttactg gtataaagcg aaaaacaaag gccaaaactt tgactgtgac tacgcgcaga 1772461 ttggatgcgg caatgtgaca cacaagtttg tgacgttgca taaaccaaag caaggtgcag 1772521 atacctatct ggaacttgga tttaaaaacg gaacgttggc accgggagca agcacaggga 1772581 atattcagct ccgtcttcac aatgatgact ggagcaatta tgcacaaagc ggcgattatt 1772641 cctttttcaa atcaaatacg tttaaaacaa cgaaaaaaat cacattatat gatcaaggaa 1772701 aactgatttg gggaacagaa ccaaattagt taagcttttt tttggcggac atcagtaacg 1772761 atgtccgttt ttatcatcta ataggaggtt tgcgttgtgg atgaaatact gaaacagtat 1772821 atggtgctgt ataaaaaaat gagtaatatg ataaatggtc ccgactatcc aggtaaggaa 1772881 aaagacatcc agcatcaaaa agatcagatc gaagtttacg aaaaacagct gcagcaagga 1772941 ttttctacag attatgacta tgatgtgttt gctgattctg ttatcaaatg cgcatatggc 1773001 gatatgacgc tggaagattt agaagccgtt tattatggat tgacaacacc atttttttga 1773061 tttgtcattc agcagtaaaa tttcaatttc tgtctcacta acttaagtat actttgatat 1773121 tgagacagaa atttatttat tttgtttact tcctagaata tatattatgt aaactagaaa 1773181 agatgaagaa taaagctttg ctgtttttat gtacatcctt tcttcttcct gtaattcagc 1773241 aacaaaataa aaaagcgatt tcccaatcgg aaaatcgcca attcagacac tctattattt 1773301 atgtgtgtct ttgtgctctt aacgatttac aacaaatgtt gtcacgcttt gagctggaag 1773361 atgagcccaa aaatgattgc ctgatacagt gagattcgtt ccaggttgta gattgctgct 1773421 gctgctcgtg atccatctag atacgtttga agcagatcca ttctgcaaaa caaagttttg 1773481 gttgactcct gtgttgcttt tattgatggc aacaataacg accttgttgt cacctttata 1773541 ggctgacacg taaacgttcg cattagggtt tttcgttgca tcaatcctta catagccggg 1773601 acgcacaaac tttgagaaat gagccatatt gtagccgcgt ttgctgatcg taccatcttc 1773661 tttcataggt ccatatgatc ttcggatgta ccaccataca taagcttgaa agtccccctc 1773721 taccatcgca ttgtgaatat gctgtgaaac atccaatgcc tcaggccatc gatccgccga 1773781 gttggtatca ctgtttggat agtatacttc cgtcatccaa aggtccttcc ccgctccttt 1773841 ttgtttgaaa agaggataag ggaattggct gacctgggtg ccgtacaggt gagttccgag 1773901 aatatccata ttggcaagag cctgcggatc gttcaagatc gggtccgaca aattcttcaa 1773961 gtattgaaat gactcaggcg caatgacgcg ggcattgatc gagccggcgt tttctctcat 1774021 aaagcgaagt atttcttgcg gcgtccacca cgtccactcg tgagcgtaat caggctcgtt 1774081 ttggaccgaa atcgcgtaaa gattcacacc attattcttc atgaaggtaa caaaatcgtt 1774141 aagatgctgc gcgtatgctg cgtacttgtt gtatttcagc cgtttagccg atgtgtcacc 1774201 attccgatta aaggtctcaa ccatatcact tggaggattc caaggagaag caaaaacgat 1774261 tgctccgtgt ttgaccgcac tctttgcagt ctccacctct ttataccaat tatttcgatt 1774321 ttcatctaca tgaattctta agattgaaaa tcctaactgg ttctgtccat tgccaaaagc 1774381 agtttctctt tgagctgctg taagatcccc agcccaagcc ggatgattca tccctccaaa 1774441 accgcgaatc acttgtttct ctgcagatac attaactgtt acatcacttg ctgccaaaac 1774501 ttcagtagcg cctggcccta acatgactga cagcatagtg aaacatacta atagtacaca 1774561 aattgttttt tttatgcgtg gaatcattta ttcctctcct tcgtcatgtg tcttttacgg 1774621 tattaaaaaa tctgcatggc atatccataa tggcgggctg ttccggtgct ggcccgtact 1774681 tcacccgcct cgtttttaag cggtcccatt acgagtacta tctttgcgta aactgccagt 1774741 aatcaaaatt aaacaagttt cctgtacctg ttccggtaaa tacaaagaat actttgtgca 1774801 caccggttgc cccgcttacc gcagtttcta tttccctcca cgtttgcgct ccgcctgttg 1774861 aaggcacatt cagagttcca acaagcttac cgtctgcact gtcgaggcgc acttctattt 1774921 tcccgcctaa agtggatgct acatttgctt taaatgacct ggcaccgccc gctccgaagt 1774981 ctgcatttcc tacagcaatc cagtctccat tttgaatgct tgttacatgc tgattattta 1775041 ctggcccgcc gggtgctgtg gacttctctg tcaaaatgcg tccattccaa gcaaacgttt 1775101 cagcttctac ccggttatat gggtttaaat tggaaatttg tgttacacct gcataatttg 1775161 ccgctacctc ttgaatagat ccatctgcat tatgcaccag cttattaata tggggagagc 1775221 ggtatccttt gccggccccg aacagagcgg aactgacagt ttgcgcatgg tacaccacat 1775281 accactcgtt tttaaaattg aaaacagcat gatggttgtt tccgccacct ccgaaaaatg 1775341 cacccggatt tttcaggaag tgccctctat atgtaaaggg acccatggga cttgaactgg 1775401 tcatgtagcc gatctcaccc gggggtttat cggccgggtg cgtgccgccg aaattgatgc 1775461 aataggagta ataatatgtt ccgttatact tgtgcaatcc cgaatcttca aacatgaaag 1775521 gcgcatcaat tgtagatgca cttccaacaa cactcgtcat atcaggcccc aattttatga 1775581 ctctagccgt tttaggattg gcccattgtc cctgcgttgg atttgaaacg ccaggaacgc 1775641 ctccgccggc atacaggtaa ccggttccgt cgtcatctac aaatactgcc ggatcaaaaa 1775701 gccatacaac accagacatt cctggcgtac ttggcgttac gagcggtttt ccgattgggt 1775761 cggtccatgg accaatcggg ctgtctgcgg tgagaacccc gatacctccg ccgctgtttg 1775821 cgaaataaag gaagaattta tccttgccat taattttttt aactgcgatt gacggtgccc 1775881 atgacgcacc tgcccatttt gcaattccac ggcctccatt agctccattg gcacctgcta 1775941 ccggaatggc tccgtggtct gtccagttca ccatatccgc tgaagatatg acgaatactc 1776001 tattcaaatt ggcaaatgaa ttatctttaa ttgttccgtt gctattatat tcatagtcat 1776061 cacttgacat atagatgtag actcttccgt tataggtcag cgcaaccgga tccgctccca 1776121 aatgatggtc gataagcgga tttgaattcc ctatatgttt tgcaattgta gtactagtgg 1776181 cagcatacgc agacttccca gataagcagc tcaataataa aactagaatc cataaacata 1776241 cgctacactt tttcctcatc acttcacatc ctcctttttc cttaaaatgg gggattttct 1776301 tttggaattt gataacaaca ggtcacgaag attgcacgca taaagtagcc ggaagctgtt 1776361 tagcaatgtt cccagttgtt ctgaaagctc atcttcatgt gtctccattc tctcttttct 1776421 tcgaggagat cgcaccactc cttcaaaatt gttcaaaaaa acttccccat tcctagcgac 1776481 cattgtccag aaaataaaaa gacaggattg ttcatggcct cccactaatc acattgaacg 1776541 gagattacat cattatccaa gatatccctt tatctaacat cctacatcat taaaaaaatt 1776601 gtgtatagaa acttttggag gagttagtgt tcgattctac aaaggaactg gatacattta 1776661 ttcattgata agatggggct aacactccgt ttatatttgt atgttttcag acacaaaaaa 1776721 cagccgttca atgcggctgt ttttttcaag agtataagac tattgagcgg tatacccgct 1776781 ttttcatgtt ttgttcatat tttattaatt gtttattcaa cactgtccgc tatagtaatc 1776841 catatcaaca aatatgactg ccactcgcat cttttatgaa gggaggttcg ttacgctgaa 1776901 agaaaaaata aagacattag gccgtttttg caccgtaggc gtcggcaata cgctgataga 1776961 ttttggtgtc ttctttcttc ttaccgcttg tcatgtctct tatctgccgg cgcagatctg 1777021 ctcctatact gcaggtatcg tcaacagcta tgtgtggaac cggaattgga cgttttgtgt 1777081 gaaacgtaag gctgacggga aagagatcgt gcgttttctc atgattaata ttgccgcgtc 1777141 agggatcacc tttttgctgc tttatttgtt tcaaaattgc ggctgctcgc ttttggtgag 1777201 taagctcgcc gccactatcg gcggaatgat gatgaatttt atcggaaacc gaatctgggt 1777261 atttggagat tcgctgaaaa acatacagga tcaggagtga agatgaatga gaaaaaaagt 1777321 gagaaaagcg gttatacccg cagcgggttt aggaacgaga tttctgccgg cgacaaaggc 1777381 gcagcctaaa gaaatgcttc caatcgtcga caaaccagca atccaatata ttgtagaaga 1777441 ggccgcagag tcaggaattg aagatatact gattattaca gggagaaaca aacgctcgat 1777501 tgaagatcat tttgatcggt cggcggaatt ggaattcaat ctccgggaaa aaggcaagac 1777561 ggagacactt aaggaaatgc agcagattgc cgatttggcc aacattcatt acatccgcca 1777621 gaaagaaccg ctcggattag gccatgcggt gctgtgtgcg gagcatttta tcggagatga 1777681 gccttttgct gttctcttag gtgatgatat tatggtgtct gaaacaccgg ctcttcggca 1777741 attaatggat gtatatgacg tttatggcac agaggttgtc ggtgtacagt cagttctccc 1777801 tgaggatgtc agcaaatatg gtattataaa tacatcaggg tctcaagggc atgtatatga 1777861 agtgaacgat ttagtggaaa agccttctcc tgaagaagca ccttcggaaa tcgcagtaat 1777921 gggacgttat gtgctgaatt cttcgatctt ctccgttttg aagacaattg gcagaggcgc 1777981 gggcaacgaa attcagctga cagatgcgct tcgtgaggtt tgccgtaagg agccgatcca 1778041 tgcccggctg ctggaaggaa atcgatatga cattggcgat aagctgggct gttttaaagc 1778101 gagcaccgaa atcggcttaa tgcgtcccga aatgagatct cagcttttgg cctatttaga 1778161 agatgtgatc aaacgggaaa cgaaagaaat gctgcggtaa aaaaattgta accatcttgc 1778221 tcgtcaatca gtcatataat agtgaaaaag attaggacag gttgtgaaga atgtgggcag 1778281 tttgataagc gaaattttaa catggctgac gaacatggga tatgcgggta ttgcgattgg 1778341 gttaatgatt gaaatcattc cgagtgagat tgtattagct tatggcggct atatggtatc 1778401 ggagggcacg attggattta ttggcgcaat tattgcgggt gttatcgggg gcaccattgc 1778461 ccagatcttt atttactgga tcggtcgcta tggcggcagg ccatttctgg acaaatacgg 1778521 gaagtattta ttgattaaaa agcatcatat cgatatgtcg gaaaactggt ttcagaaata 1778581 cggcgccgga gttgtcttct cggctcgttt tataccggtt gtcagacatg ccatatccat 1778641 tccggcaggt attgccagaa tgccttttct caaatttgtg gtactgactg tgcttgctat 1778701 cattccatgg tctatcctgt ttgtttattt aggcatacag ctaggaagcc agtgggatga 1778761 tgttgagaat atagcaggca cttatacaac accgattatg atattggctg ttgtcgtgat 1778821 agccctttat tttgtgatta agaaacgtac agccatattt aaacgatagc tagcggatat 1778881 gcataggggt gactgacgct cccctatgca tattttttta cttgcgatgt tgatttgcca 1778941 gcttcagatt ctccgctaaa aatgcgacaa acacttcatc ccgcacgagc gatgcggcat 1779001 aatttctctt aataaaccat tctgcctctt caaacgctgc gaatgtttcg tcttgggttt 1779061 ctccgttaat ttgaatattc cattcgttgt ctaaagggaa aagaaaaaat ctcatttgtg 1779121 cgcgattttc atataatgat ccattcgcag atccctttag attatagatg ttacggaagg 1779181 catccggccg tacaggatca atacggaaag cttcagctac aaacaactcg tatacttcat 1779241 cggttattga acagccggac gcttttgcat gccctccgcc gccatatcgg ccggcgattt 1779301 ctgacacatc gatgtaatca tgaatggtgc ggagactgac tcgttttgac cccatgctca 1779361 aaatcgcaat gtaatcgagg tgcgggttat ctttccctag cctgttcccc agctctgaat 1779421 ggtacgattc agcgtgaacg atgcctacac agtgttcgtg aacaaaggtt tgtaccattt 1779481 cccttttctt tctgcggagg tagcgctcga ttttttcgtc ttctaaatca agcagttttt 1779541 cttcaaaatc atcgaagaaa aattcgtcat gcgtggaaag gcgctggatc atttttgctt 1779601 caaattcatc gattgacagc aaaaagaaaa gatcattaag ccgcttcgcc tgtttttgat 1779661 cgtaccgctc ccactcccat gtatcgtatt ggcggacgag ctctgtgaat tgatctaagg 1779721 cgtttgtcgg tttcatgaag ccattttcaa tgagatagcc atataaaagc gatgtcgcgg 1779781 atgtgagcct tccatcatcg tattccacct ggacaaatcc ccattcatgc tcattcaaat 1779841 gaagggctgt tttatgatgg tcaatgagct tcactttgcc ccctgcatga acatactcat 1779901 tcaatctctc ttcgttttct tcattgacgg cgagatcggt gatgaataac gcgtcctgtc 1779961 tgttgctctc cttcgctttt tctaaaaagt actgcacctg tgcgtttaag ccgttgacag 1780021 agttataccg gatctctacg tcttttccga acgccaattt tgctacgatt ccgcatccta 1780081 ctccgtccaa gtcgttatgt gaatataaat gatacataat gtaggcccct ttttatgata 1780141 aactgacaat tgccgctaga ggtgcggcag cctttattta ctattctaaa aaaccaagcg 1780201 ttttatgcaa tggtaattag ttgacataat gttgttattg taaatatata aaggagcgct 1780261 ttttttgcgc tcctaagttc ttgcttttac accggataaa ccggatgctt tcgattggta 1780321 aatgtcattt cctttgtcat gtatgccttg agccgtttgg ccagctcatc acgcagcgaa 1780381 ttggctggga taacagcatc aatgatcatt tctgaagcca gacggtagat attgatgtcc 1780441 tctttgtatt cctcccgttt gctgctgata aatgcggctc tctcttcttc tggcagctcg 1780501 gcgatttttt tagcgtagac agcgtttaca gcggcctcag ggcccatgac ggcgatttgg 1780561 gcggttggga gcgctagaca gcaatccggt tcaaatgccg gccctgccat tgcatacaac 1780621 cccgccccgt aagcttttcg gacaatgaca gagagttttg gaacagttgc ctccgacatc 1780681 gcagaaatca ttttcgctcc gtgtctgata atcccagcct gttctacttt tgtgccaatc 1780741 ataaaaccgg ggatatcggc taagaacagc aatgggatat gaaaagcgtc acataaggta 1780801 ataaacttag ccgctttgtc tgctgaatcg tggaataaga cgcctccttt taccttcggc 1780861 tggtttgcaa caatgccgac aggctgtccg tggattcgtg cgaggcccgt caataattcc 1780921 ggtgcaaata aggctttgat ctcaaaaaat gagtcttcat ctatgacccg ctcaatgagc 1780981 tcatgcatat caaaaggtgc gttttgattt tgcggaatga cgtcggcaag cggagtttcg 1781041 aagtgttttg gcgggcgttt ctcatgaatg ggcgcttttt cttgaaaatt tgccggaaag 1781101 taagacaaat aagcccgcac cagctgtatg gcttcttctt cagtttctgc aagaatatct 1781161 ccgcagccgg agattgagca atgcatacgg gcgccaccca tttcttcgag agacactttt 1781221 tctccaataa ccatttccgc catccttggc gaacctaaat acatggaggc gttaccgtct 1781281 accataacga cgatatcaca gaaggccgga atataagcgc ctcctgccgc agatggtccg 1781341 aaaagcagac agatttgcgg aatgcgtccc gataatttga cttgattgta aaaaattctt 1781401 cctgcaccgc gtctccctgg aaagacattg atttggtcgg taattcgggc gcctgccgaa 1781461 tcgactaaat aaatgagcgg acagtttaat ttttcggcga tttcttgaat tctgatgatt 1781521 ttttcaactg tttttgctcc ccatgacccc gctttcactg ttgaatcatt cgccatgacg 1781581 caaacggttt ggccgccgat tttgccgata gcggttacaa ctccgtcagc gggaagcccg 1781641 tctgacatac attccgcaaa aaaagcgtct tctagctcaa tgtcatcgtc aaagagaagg 1781701 gaaagccgct ctctgacaaa gagcttgcct ttttcccgat tgctttgatg atacttttcc 1781761 gctccgcctt ttcgaatccg ttcagcccgt tctgttcgtt ccttttcata atccatcagc 1781821 attgcctccc ttttatattc ccttgtatac ggcccgtctt ttttcttgaa aggcctgaag 1781881 cccttctctc ctgtcttttg tcgggatggt ttgttcatac gctttttgtt caatcgcaag 1781941 gcctgtagca agatctgtct ccaatccttt attgattgca aatttagcct gacggacagc 1782001 gatcggtccg ttggcagaaa tggctgcggc cagttcctct gcttttggca taaggtcaca 1782061 aggagccgtg acatgctcta caaggccgat ttcttttgct tcgtgtgcgg tcacgcgtct 1782121 gcctgtataa atgaattctt ttgcttttcc tctgccaatc agccggggca gcctttgggt 1782181 ccctccagcg cccgggataa tagctaaccc tgtttccgga agtcccagca cagctgcttc 1782241 agttgcgatt cgaaggtcgc atgccaatgc caattctagt ccgccgccta atgcgcttcc 1782301 atttatcgca gctatgaccg gctgcggcaa ggcatcaagt aaagccgccg ttctttgaat 1782361 gagagataca ctttccagaa cctgatcttc tttcagtttt atccgttcct tcaggtctgc 1782421 ccctgcacaa aacgcttttt caccggtgcc tgtgaggatg acgcaacgga tgtttgagtt 1782481 aaattcaatt tcctggataa tcatttgcag gtttctaagc atttccgctg aaagagcatt 1782541 tgctgcctga ggcctgttta aggtgatcaa cgccatatgt tcatttttaa cagtaaaaag 1782601 aatagaatct cccattgtat gcgtcctccc ttttatcaag atgatttaaa cacctgtaaa 1782661 tttctgctcg gcagcggttt gcccattttt tcttcaatcc atttggccgc agatagcagt 1782721 ttttctagct ttacatttgt tttgatatcc atctgttcaa gcatgtacac gatatcctca 1782781 gttgcggcgt ttcctgatga acctggcgca tatgggcatc ccccaagccc gcctgccgag 1782841 ccgtcgaaca ccgtgatgcc catttggagt gctgtgacca tgttggccag agcggttcct 1782901 ctcgtatcat gaaaatgcag ggcaatttga ttagccggga atcgtgccaa aagagcttca 1782961 agtacagttt ccacttgggc gggattagct gctccaatcg tatctccaag cgacagttca 1783021 gaaatcccaa attcaaatag agcttctgaa aggcgaatga cttgttcaat ggggacatct 1783081 ttttcgtacg gacagccgaa aacagtcgag aggtaggctc ttgttgtgag gtttgctttt 1783141 tgtgcgtcgt tgtttacttg tttgagtata tggagggatt cagaagtgga tttattgatg 1783201 ttttttctgt tgtgcgtctc gctggcggac ataaaaacgc aagcctcgtt aatgcctcct 1783261 tcaagtgcat tctccagtcc tctttgattc gggacaagtg ccgcgtacgt tacccctttt 1783321 tctcggtcga tgccttttgc tacatcgata gcatctcgaa gcgccggaat ccatttcggg 1783381 tgaacgaagg atgtgatttc aatatacgac agccctgtcc gggaaagctg gttgatccag 1783441 gttattttat cctctgttgc gatccaaacg ggctcgtttt gtaagccatc acgcgggccg 1783501 acttctttga ttgtcacttt tttaggatat ggcatggtct tcctccaaat tattgagtgg 1783561 aattgctcag ttcgagcagt acgtctcctt catttacaaa gtcgccttcc ttttttttga 1783621 cttcttttac gattccgctt ctatctgcaa cgatcgggat ttccattttc atcgattcca 1783681 aaatggctac ctcctggccc ttttcgattt ggtcgccggc tttgacgtgg actttccaca 1783741 ggtttcctgc catttgtatg ctaaccgtca tgacaactgc ctcctttata ggtgctgttt 1783801 caaaaagtca gtcgtgacat ccccttcttt aaatgccttt gttgccgcag cctgtatgag 1783861 gagcggaagg tttgttttga ttccctctac acgatagtcg cgaagcgctg tctctagttt 1783921 ttcaattgct tctgttctgg tttggccttt gacaatcatc ttagcgatca tcgggtcata 1783981 aaaaggggta acggtgctgt cttttgctac cgcacattcg tgtctgactc ctttttggtc 1784041 aggaagtgaa aacgcagtga tcgtacctgg tgacgggaag aaggtcttgg gatcttccgc 1784101 gtatattcga acctctatcg catgcccgtt ccgttggatg tctttttggg agaatgtgag 1784161 tgtatggccc gcagcaatcc gcagctgctg ctcaactaag tccaggcctg ttatttcttc 1784221 agtcacgggg tgttcaactt gcagtctcgt attcatttcg aggaaataaa aattttgttt 1784281 ctggtcaact ataaattcga tggtgcctgc gttcgtatag ccgattgcct tcgctgcttt 1784341 taccgctgtt tgaccgatct tcattcttag ttcatcgtct acaaatggag acggtgcttc 1784401 ttcaatgact ttttggtggc gcctctgaac agagcaatca cgttcaaaca gatgtactgt 1784461 atggccgtgt tgatcggcca aaagctgaac ctcgatgtgg cgcgcatgtt caataacttt 1784521 ttctatatac atagacccgt caccgaaaaa atctgctgcg cgctttttgt ttccctcgta 1784581 cgcttttttt aatgcttctt cattttcaac acgctgcatt ccgatgccgc ctccgcccgc 1784641 tgaagctttc agcatgacag gatagccgat ttgacttgcg gtgcggcagg ctgcctctat 1784701 atctccgagg gattcagaaa cgcccggcac cacagggaca cctgcagcct ccattgcttt 1784761 tcgcgcttca attttgctgc ccatctttgc gatgatatca ggggaaggtc cgataaacac 1784821 gatgttttct tgcttgcagc gttcagcgaa ccggctgttt tctgataaca atccatatcc 1784881 cgggtggatc gcgtcggctt ttgctttttt cgccgtcttt atgattctct ctatatttaa 1784941 ataactttca ctgactctcg attccccgat caaatatgcc tctgtagcgg cttttgtatg 1785001 gggcgcgtcc ttgtctgctt ctgaataaac agcgaccgtt ttaatgccga gacggctgca 1785061 tgttcggata attctcattg caatttcacc gcggttggcg atcagtactt ttgtaaacat 1785121 gatttcacct cattgacttg atgataagtt gaacatttca atcgtttttt ctcgcagttt 1785181 atatttttga attttgcctg aggccgtcat cggatagtca tccgtaaaaa taacataacg 1785241 cggaattttg tggcgggcga ttttcccttt gcaataggct ttaagctcat caggtgaaac 1785301 gcttttaccg tctttcagtt taatccaggc tgcagcttcc tccccgaatt tggcgtcagg 1785361 cacaccaacc acctgtacat ctaaaacagc gggatgctgg tataaaaatt cttcaatttc 1785421 ccgcggataa atgttctcgc cgcctctgat gagcatatct tttaatcttc cggtgatgcg 1785481 gcagtacccg tcttcatcca tgacagcaag atctccggta aacagccatc cgtcatgatt 1785541 gattgctttt ctggtcgcat ctttgtcttt ataatagcct ttcatgacgt gatagccacg 1785601 ggtgcacagt tctccctgca tgcctctttg aacttcttga catgtcccgg gttctacaat 1785661 tttcacctca gtatgtggca gggcacggcc ggttgtttcg actcttctta tgaaggaatc 1785721 atttgctctc gtttgtgtaa tgactggcga ggcttcggtt tgtccatagg cgatcgtaat 1785781 gtctttcatg cccatccttt caatcacagc tttcatcact tcacttggac agggagagcc 1785841 ggccatgatt cctgttcgga gcgtcgatag atcatatgca tcaaaatccg gatgatgcag 1785901 ctcggcgata aacatggtag gcacaccatg gagcactgtg catttctctt tttctaccgt 1785961 tttaaggacg gtaacgggat caaattcttg cacgggtatc atggctgccc cgacggatac 1786021 acatgccaaa accccaagga cgcatccaaa gcagtgaaaa aacggaacag ggatgcacat 1786081 gcggtcttga gaggttaaag ccatacattc agcgatatta gcagcgttat tgatgacatt 1786141 gaaatgggtc agcatcacgc cttttggaaa ccctgtcgtt cctgatgtgt attgcatatt 1786201 aatcacattg tctttatcca ggctgttcat tctctcttca agctcagcat ctgtcactgt 1786261 tttcgccaat atctctgtat cgtcccaatg atacatgcca gacaatcgtt tattgccaat 1786321 atagatcagc gtttttaaaa agggatagcg ttcagatttc agttggccgg gctttgcttc 1786381 ttgcagttct ggaattaaac tgttcacgat gtctggataa gaagtgcccc tgtatgaatc 1786441 catgataata agcgccgcgg catccgattg ctttaacaag taatcaagct catgtgcttg 1786501 ataattggta ttgacggtca cgagcacggc tccgatcttc gcagttgcga actggacggc 1786561 aagccattca gagatattag aagcccatat ggcgacgtgg tctccttttc caatccccat 1786621 ccgcatgaga cctttagcgg tttgacggca cagactgtca aattgagcgt acgtatagcg 1786681 gatatttcgg tctggataca caacagcatc tcgatcggga tacgcatcag ctgtttgttc 1786741 cagcagcctg ccgattgtgg aatggatgag ttcagccatt cattgttcct cctttcttaa 1786801 tgataggaaa gcgtttacat ttttatttta aaagctgtct ggcgatcacg agacgctgaa 1786861 tttcagatgt gccttcaccg atttccatta attttgcgtc ccgcagcatc cgttccaccc 1786921 catactcttt catatagcct gaacctccat ggatttgaat ggcttgattg caagctcttg 1786981 tcgccatttc agatgcgaat agcttggcgt acgccgcttc tttggtgaac gggcggttat 1787041 gatctttcag ccaggcggct tttaacacca tttgccgtgc cagatcaatt tccatcgcca 1787101 tgtcagcaag cttaaattga atcgcttgaa aggaagaaat cggctgtcca aactgctttc 1787161 gctctttcgc atatgccaat gatgcgtcaa gggccgcttg ggcaatgccg actgcaagag 1787221 cagcgatgga gattcgacca ccatccagcg tatatagaaa ctgtttaaac ccttttgttg 1787281 gatcgccaag taagttggcc gcaggcactc ttacatcttc aagcaagatt tccgctgtat 1787341 tcgaaccgcg gacgcccatt ttatcgtacg ggctcgtaat cgtaagtcct ggtgtgtcag 1787401 ttggcacgat taatgcggag atgatgtttt ttccgtcttt gtttttgcct gttacggcgg 1787461 ttacaataac tgtgcgtgcg tagcttgcat tagtgatcca gcacttttcg ccgttgatta 1787521 catactcgtc accatttgaa atcgcttttg tttgagtgcc tcctgcatct gagccggcat 1787581 ttggctccgt caggccgaat gatccgagtg ctgtgcctga agccagcggc gtcaaatgcg 1787641 tctgtttttg ctcttctgtt ccgaagtagt aaagagggct tgcgcctagc gagaccgctg 1787701 cagcatagct taatccagta ctgccgcagg ctttgccgac ttcttcaacc gctaaggcat 1787761 atgaaatcgt atcaccgcca gatccgccgt attcttctgg aaatggaata cccatcagac 1787821 cgagttcacc cattttttta aatgtttgca tcgggaactc gcctgtttga tctacatgtt 1787881 cagcgtgagg agcaatttct tttttcgcaa aatcttttac catttcacgc accatttgtt 1787941 gttcttttgt cagctcaaaa ttcacatcgt ttcctccttc acatctttgt aacatcctat 1788001 taggcgagtt ctataatcat tccctgacaa gaaaagtctg aaaattaaaa ctgaatcatt 1788061 ttttatgtga taatatcagc gggatgagca aatacatgca gtaggcgcat accatccata 1788121 tcgtaaacgc aataacttgg ccctttgata aagccgggaa gatgagggga agattccaaa 1788181 gggaaatcgt atccatcaat aaaccgaccg ctgatcccca tatacctagc ttgatcaccg 1788241 cgaactgtga ttgatcgagt ttttgataga gaaagaacac aaggcataaa acaagagcag 1788301 tgcccgctcc caagagaaga aagttcggca aaaaggcttc ttcagccgga tcagtcaaca 1788361 cagcatctcc gaacagcaca aaaaataatg tggcacctaa ccagactaga aatgaaaacg 1788421 taaaacacgt cctgtacgtg tttctcttcg attttatttt tatttagtac tagtttctca 1788481 gattccaata atggtaaatg tccaaacacc gcctccatat tcatgtgaat ctcacctttg 1788541 ttttttaaaa aattcagcgg tttaccatcg tttcctgtcc caaaatcact ttttaaaaaa 1788601 agacgactta gaaagccgtc cttctcattt cttattttgt tgttcgtttg gaagctttgc 1788661 tttcgttatg aagccggtct gctgaagtga cataatacgt atatttcttg ttgggatctg 1788721 ccgtgttatc taagaaggtt tgctgctcat gtgtttttct ttgcgttgcc agcaatgttc 1788781 tctgcttttt cccttcggct ctgtatatcg cataataggc tgtttctttc gttttttgat 1788841 ttgatgggtg atctttaatc tgcagaagat tgccgttttt gtcttcggtg actttcgtaa 1788901 gcttcggttt ttttggggcg gtattgtcaa gccaaggcat ttgcggaacc agtgccggct 1788961 tgctgtaaag atcggtgctg agactgtctt tgatgccaag cggatttttg ttgaggtcct 1789021 tgaggctgaa atgcatgctt cctttcacca gttcaagctg gcggttcaaa gtgatttgcc 1789081 gcacatattc ctcaggatcg gaccaaggcg gatcaaaatt gttattgatt ttatatgctg 1789141 cctggccaat atataagtga acaggcctat ttttgacttc attgctccac caatcagcca 1789201 gcacgtcgta agccgctgcg ttaaagccga tactccaata aatttgcgga gcaatataat 1789261 cgatgtcgcc ttcttggatc caatgccttg tgtctgcata tagatcgtca taatttctga 1789321 cgcctgcttt tgtattcgat ccggtcgggt catctgcggc gtttctccat actccaaagg 1789381 gactgatgcc gaatttgaca tacggttttg cagctttaat tgtttggttg atttgtttga 1789441 caagctggtt cacattgtcc cgccgccagt catcgatatt agaaaaagcg tcttttccgt 1789501 attgttcgta ctgtgcttga tcaggaaatt cctgtcccgc tattttataa gggtaaaaat 1789561 aatcatccat atgaacagca tcgatatcat aatgttttac gacttcttca atgcctttga 1789621 cgataaaatc tctcgcttct ggaatgcctg gatgataata cagctggttt ccataggcgg 1789681 caacccaatc tggatgtttt cttgccgggt gatcctcaga caatttatta agatctgtat 1789741 gattcattgt aatacggtaa ggattaaacc acgcgtgaaa ttccaaattt cgtttatggg 1789801 tttcttcaat cataaatgca agaggatcat agccggggtc cttcccttgg acaccggtta 1789861 agtattccga ccaaggcccg taagctgacg gataaaaggc atcagccgtc ggtttaatct 1789921 gaacgataac ggcattcatt cccatttttt gcacatcgtc cagcagtttg atatactcct 1789981 gtttttgctc tttcacagat aacccttttt tggacggcca atcaatattt aatacggaag 1790041 caatccatac ggctctcagc tccctgtcag actgcgcatt ggccataaac ggaacggaaa 1790101 tgacaaacgt tccgatgatc aagctgacaa ggaaacggac aatcgacttt tggcaaacct 1790161 tcattctgtt tcttctcccc cattacatca ctttcactat tcgctattac ggtattcccg 1790221 ggctataaaa gggtgattaa cagaatgtct atctcactaa ataaacgaaa aaagtcctaa 1790281 agcatgttgt gaaccgcttt taggactttt tatcattcat catggtttgc agacttttta 1790341 acacatcaat aagttttacg ccgacaccga cagccgtttc aaggatcgct tgtgctccgg 1790401 caatggctaa aataaagatc agcggtattg caatacgagg caaaaaaaga tagccaagtc 1790461 cgatcaagat ggcacaccaa acaccggcac accagtagca attgagcatg tatccaaagt 1790521 tagaagccgg cacgcttttt tcatctacat gcccgttttg atcaacaatc cttttctttt 1790581 tcataaaagg ttttcggata aattctgtga ttttgtcaaa tacaatcaaa tgtgtcagcc 1790641 tgtaactggc tagaatcagc atgataaaag ttagaaaaga aagacggtcc attgagaagc 1790701 ctccaagaaa aaggatgatg ttatcattcc caagtgtccc ttatccattc ttgatacaaa 1790761 aagaaagacg gacagagaat ggcctctgtc cgctaatccg ctttatcgtt tgtgcagtat 1790821 tacttgattt gaagtgatct tttctaaaat gtcgaggatg atgtcggcat tcttttcagc 1790881 atatgttcct tccagcatgt ctttatgagc gccaaaaccc gtgtactcac tatagtttcc 1790941 gcaggcgcct tcccatttcg ttaagcctgt atgcccgctg gtttcggggt ggattccagc 1791001 ttcgatgaaa tgaatgcttg ctttgatgtg gccttcattc agcaattgtg cccaatattc 1791061 ctgatagttt ctttttttct tcatcacctt ttctctgact gcttcaggca gatatgctgc 1791121 agattcgtca ttaccggtat cgataggcaa aggctgttct tttagataag cgtccacgat 1791181 aatgaagtcg ctgacttcta atcctttgcg ctccatagcc tgtgccactt caaaagccag 1791241 gtttccgcct gcagagtagc ctaataaaac gtatgggccc tcaggctgta tgtccgtcat 1791301 gcaattaaca tattgttcaa tgcgggtgtc ttgttcaata aagtgaaacc cgtatacggc 1791361 tgccttctca ttcagcaata aagcaaggtc tttaaaataa atgccaaatc ccgatatcgg 1791421 cgggaagcag aaaagatttt gcgcgccgtg ctggttcagt ttgatcacat gctgttcatt 1791481 tgctgctgtc agctgtttag aataaagttt ttcggcaagc tgagcgattg tcggatgttc 1791541 gaacaagaaa tcaatcggta tgtcaatgtt ctgctgatgt tttagtgtat gtatgacttg 1791601 cagtgctctt agtgaatgtc cgccaatagc aaagaagtca tcatcaatac tgattgtgtt 1791661 aacaccgagg acttgcttcc aaatgttcgc caattcttct tcaaccaagt ttcttggcaa 1791721 tatgatgttc tgtcgtttgg caggcttatt ttctggaata ggcagcgcgc tgcggtctat 1791781 ttttccgttt ccggtaagcg gcatccgctc cacacgcacc cagtgctgcg ggatcatata 1791841 gtctggaagc acacgcgcca aatcggcgcg aaaatccgta tctgtttttt tgtgatcacc 1791901 gacgtaatga gtgtacagct gcgcctctcc atctttttct ctcaatgtca ctgctgcttc 1791961 ttgaacgcct tccatttcta acaggcgcgc ttctatttcg gcaggctcaa ttcgttttcc 1792021 gcggattttc atttgcctgt caattctgct gatgtattct aagtttccat caggcagcca 1792081 gcgcgccaaa tcaccagtac ggtatattct ttctccaggc aagaaaggat gaggagaaaa 1792141 cacagcattt gtcagatcta ctctgttcaa atagccttta gcgactccat caccgccaac 1792201 acaaagctcg ccgggaacgc ctattggcaa aagacgtcct tttgtatcta agatgtaagc 1792261 ggtgctatta ctgattggtt ttccaatcgg aatcggcccc gcatagtctc tcttcatttc 1792321 aaaaaaggtt gaaaaagtcg tgttttccgt tggcccgtaa atattatgaa gcgcgagatc 1792381 tggacaggcg tgtctgacgg cattcatcag ggcaggagag agtgcttctc ctccgacata 1792441 taacgtatgg agtccgcgaa acatgtcagc tcgtacctgt gccagctgat taaaaagagc 1792501 tgtcgttaaa aatagcactg taatgtcatt ttcaagcaaa tacgctccaa accgatcagg 1792561 tgtcagcatt gtcgatttat caatgatatg aaggcttgcg ccatttaaaa gtgccccgaa 1792621 catttcaaag gtgacggcgt caaagctgat agatccagtc ataataaacc ggtcatcacc 1792681 ggacgcagac gtgtaattgc tgtttctgac aagggacacg acattgcgat tcgtgatcat 1792741 gacccctttc ggccggcctg ttgatcctga ggtatacatg atgtacgcaa gatcatccgg 1792801 gctggagctg atattaatag ggatatcgtt ctcttccatc aatccctgcg catctgaaat 1792861 gatacatgtt cctgagaacg cagcgttttg ctccaatccc ttttgaacaa tcagcatttt 1792921 tgcctgcgtt tcctcaagca taaagctgac tcgttcaggc ggaagctccg catcaagcgg 1792981 gaggtatgct ccccctgctt ttaatacggc aagcacactg atcatgaatt cgggagaatg 1793041 tgcagccaat attccggctg tctcgttttt ccgaaatccc ttttgaatta actctctggc 1793101 gagcgcatta gagcgtttat caagctcttt atacgaaata gacatattgc catacacaag 1793161 tgcggtatgg tctggcgtct tttctgcttg ttcgcgaaat aaatcgataa ttgtatgatt 1793221 ctttggatac tccgtttttg tattgttgaa ctgtgtgaca atctgctctt tttctgttgc 1793281 atcaagaaaa gaaaaatcag caattggcat atgagggtgc tgtgcagctg tgctaagcgc 1793341 ttgcgtaaat tgcctcttga tacagctgat ccaggcagca tcgtaaacga atgcattata 1793401 gctgaacttg atgacaagct cttcgccagg agcaacgaca agattaaagt tatatcctga 1793461 ttgctcggat acttgaactt gatcgatttg cagcggtgaa tcggtttgat cagcggaatc 1793521 ggcgattttc tgctgtaacg gatagttttc aaagacgata atgtgatcaa tcagttcctg 1793581 ttttaatgcg gtgtttgcct gaatatcaaa taaaggctgg caggtaaacg gctcagcttc 1793641 cagcatttct ttctggcagc gtatgagcag ctcgtgaaac gtttcgtctt ggtgtgtttt 1793701 aattcgaatc ggtatggtat tgataaacaa ccctatcatt tgctccacgc ctgggatttc 1793761 tgacggtctt cctgatacaa ctgcgccaaa cacaacgtcg tctgtgcggt tatattgctg 1793821 cagcatcaca ccccagactg cctgaataag ggtagcgagc gtgacgccgt gttgtttggc 1793881 agtctctttc agcttgtctg tcagtggttt atttaatgaa aatatcaaat cttcacggtg 1793941 ataactttct tttgtttctt tatcagacac acgaggcaga ggtgatggag cgctgtagtt 1794001 ttttaaatag gtatcccagt aggccgctgc tttttctttg tctcggtttg tcagccatga 1794061 aatataggtg ctgtacggac ggacagggtc taatgaaagc ggttttcctg catgaatcga 1794121 ttgataaatt tgcataaatt cctgcataac gatacctagg caccatccgt ccattaaaat 1794181 gtgatggtga ctccagatac agacatgctc atctttagct gttttgaata gagaaatccg 1794241 catcagcatg tctttttgca gatcaaagcc tttttgcttg tccttctctt taaagcgttc 1794301 aatatactca ttctggtcgt ttgtcggcag atgagaaatg tcttcgctgt tcaaatggaa 1794361 ttcacgttct gtcatcacga cttgccgagg tcccgacaaa tgcgggacgt gcggcaaaaa 1794421 cacggttctg aaaatatcat ggcggtcgat aatggcttga atgctgcgct ggaaccagtc 1794481 atagctgagg cttcctttaa tggtgaagag cgactgctca acatacgccc cctcctcttt 1794541 acggaggaag gaatgaaaca gcatcccttc ctgcatatga ctcagaggat aaatgttctt 1794601 gattttttta atggtattca tagtgtctgc acctttcttc acggattcat tagtgaaaac 1794661 tgagcatatc agcgatctct tgcagggcgt cctcggtcag ttcttgatca tcaaaatcac 1794721 tgatcgtctt ttctgtttcg cttttgttct ggcagtgttc gatcagctgt aataaaaatt 1794781 gacggcatgt ttcgctaagc tgttcgatgg ttttgcgctg aaagcgggca ttgtcataag 1794841 tcatattgac agtcaatttt ccttctgcag cgattgcgct gatatccagc gactgttcac 1794901 ggttccatgt tgtgctgata tcacctccgg cacccagcgg agagaatgag aaggcgtcct 1794961 cctcaggtac ttcagctgtg cggccgcttt caaattgacc aagataatta aagctgattt 1795021 ctggtgcacc tgtgaaattg atgtcttttt tgccaggcgg agtcaaatat ttgatgacac 1795081 cgtagccgaa tcctttgtca ggtacacgtc tcagtgtatc ttttgttgtt tttagcacat 1795141 gaaccatgct ttcttccgaa tctggcaagt ctgcgttcag tttaatcaat aacggataaa 1795201 tggcggtaaa ccatccaatc gtccggctca catctattcc ttttaataca tcctctcgcc 1795261 cgtggccctc taatgatagt ttgaaggcgg attgattggt ccaatggcgc agcgcaagaa 1795321 tgacagaagc gagcagcatg tcctgcgtat cagtgttata tgcgctgttg gcgtctttta 1795381 agagtgctgc tgtctcttta tcgtttaagg taaacgaaat tgtggaccgt tgtccctcgt 1795441 gtgctctagt tccatcgatt tgatcaaaag gcaatgcctc tgtttgatac tcttcggctt 1795501 cgcgccaata cttgagctgt ttcattagct gctggctttc agcgtagtca gagagctttt 1795561 tcgcatacgc tttaaacgag cttgttttag gcggcagttt gatatcctcc ccgccagcag 1795621 cttggcgata ccctaaagcc aaatcttcaa gcagaacccg ccatgagatg ccgtcaacga 1795681 cgaggtgatg agcagataaa aataagaaat caccgtcaat tgtgtggaaa agaccggctt 1795741 gcagcagcgg accattcttc aaatccattt tctgctgaat atcaagtaca tggcgcttga 1795801 taagaggttc atacggtcta tttccatcag tgccgtccgg agctgacaaa tcaatcatct 1795861 gaaggccgta caacgcgtcg tccgaatgac tgagcggccg attatattga tcccactttc 1795921 cttgttcatt ctgtgtaaac accattcgca gcgcatcatg atgacacgtt attgctttta 1795981 acgtttttcg cagtgcgtct tcttgtacag aggtgcttcg atgcagcatt acggactgat 1796041 taaaatggtg tttttctttt atatcttgag aaagaaacca tttttgaaca ggcgaccatt 1796101 gtacgtctcc ctcaaccgca gcttggctgg aacttgtatc tgaatcacgg atataagctg 1796161 ccaattcttg aatggtcgga tggctaaaca aatctttcac tgccatttgc ttgcctatcc 1796221 ggtgaagccg cgcagatacc tgtaacgctt tgattgaatc tccgccaagt tcaaagaacg 1796281 aatcagctgt tccgatcttt tctgccccca gtacttcttt ccatatatct gccagtattt 1796341 gttccatttt gctggatggc gggaggaatg gacgttcacc ttcgtggttg tatacaggtt 1796401 ttggaagtgc tccgcgatcc agcttgccgt ttggtgacaa tggaagtgag tccagttttt 1796461 caataaacgc agggtgcata aacaccggca gcttgttttg taattctgag cgtacagcat 1796521 ttgtgctcaa ccctggtttt gtcaccacat aagcgcttaa ttcggtttgt cctgacgctg 1796581 ttacatgagc aactactgcg gcgtctttta caccctttat acaccggatg accgattcaa 1796641 tttctttcgt ttctacacgg tatcctctga ttttgacttg atcatcgatt cttccgagat 1796701 attcgagtgt accgtcggcc atccatctgg cggcgtctcc tgttcggtac attcgtgctt 1796761 cgggtttaaa tggattctgc gtgaatgctc tctctgtcag ttctggaaga ttaacgtacc 1796821 ctcttgcaag ccctgttcct gctatacaaa gctctcccgc aacaccgatt ggctgaagct 1796881 gatgattgct atttaaaatc agcacttgag ttccgtcaat cggctggccg atgcttacgt 1796941 atgcctgctt ttccatatgt ctcatgacgg tagtcgccac gctgttttct gtcggtccat 1797001 attcgttggc gagttcggta tgcggacata tagctaagct gcgggcgatc aattcgcggt 1797061 cagccgcttc tcccgccagt gtgacgactc taagcgtctt tacatcttcc ggctgcacta 1797121 cgtccaaaag cgctcgatat aaaacaggca caataatcat atgtgtaatc cgttgacgag 1797181 acagctgatg cttaatggcc agaatatcct tcgcttcctc ttcatgaagc aaaacggctt 1797241 ttgcacctga caaaagcggt gtaaacatac tagttataaa gccgtcaaat gagaaagaaa 1797301 agagctgcag aatggtatct gtctcgttga atgcataagc gtttcgccgc cactgaagag 1797361 tgttagcaat ccctttatgc tcgaccatta ccccttttgg acggcccgtc gttcctgaag 1797421 tataaatgat ataagccaaa tgatgggcag acgacatttg cggcagcggc gatttgtcgt 1797481 cttcctctac gctttctatc gtcaagatct ctccttcaaa gtcagcaagt actcccagat 1797541 ccgcttcatt tattgtcatc agcagtttcg ttccgctgtc gctgaggata tagcgtttcc 1797601 gttctttcgg gtattcagga tcaatgggaa cgtaacagcc tccggctttc cacacaccaa 1797661 gtatggatgc tatcatactg aacgaacgat gcatcatgat gcctactggt gtgtccggct 1797721 taacacctcg gctgcgcaat gcacgtgcga ttccattgga ccactcgtca agctcctgat 1797781 aagtgagtgt tttgtctccg ctgacaagtg cagaagcttt tggtgttcgt gcagcttgct 1797841 gctcaaacaa ttgactgatt gtttgaactc cgtattgatt cgcttgcccg gtgttaaact 1797901 cattaagcag ctggtgccgc tcttcttggg tcaggatgtc gatatggttg agtgtcacct 1797961 tcgggttttt gccgatgatg ctaagtacat ttgttaaatg cgatgcccag cgttcaatgg 1798021 tggttttctc gaacaatgcg gttgaatatt caaaaaggaa atgaatgttt ccgtcgccct 1798081 cagatgcctg tagtgtcaaa tcgaatttag aaacgagatg agaaacttgt gccggcttca 1798141 tttgcaaatc atgaagatgc aatggctcgt aatcattatt ttgaacaact aacatcgcat 1798201 caaacactgg gttccggctc atatctcgtg tcaattcaag cttatcgaca agctcttcga 1798261 acgggtaatt ctggtgctca aaggcttcca atgctgtctc acgcacttcc tgcaaatact 1798321 gtacgaatgg cttcccgccc tccgggcgcg tccgaagcgc cagcgtgttc acaaacatgc 1798381 cgagtatcgg ctcaagatcc ttgtgcggcc ggccggcgat tggcgagccg acgatgatat 1798441 cttcctgtcc gcttaagcgt gacaagaacg cggtgtaagc cgcaaggagc accatgtaca 1798501 gtgtgcttcc gttttctcgt gccagcttgt gaaggcctga tgcaacctct ggttccagcg 1798561 taaatgagac cttgtcaccc gcgaagcttc gcaccggcgg gcgggcatga tcagcgggga 1798621 gatccagcac aggcagctcg ccctcgagct gcttcagcca gtacgcctcc tgcattttgt 1798681 acgcgtctcc tgttttgaat ccttcttgcc atacggcata atctttatat tgaatgcgca 1798741 gcgccggaag cttccgatta ttgtacagct cgccgaattc ttgaatcaga atgttgacgg 1798801 aaacaccgtc tgaaatgatg tgatgcatat caaccagcaa taggtgccgc tcatctgata 1798861 cctttacgat ttgggcacgg aacagcggcg cttggctgag atcaaacggt ttgataaatg 1798921 cggctgcggc ctcctgttcg gttcgtgcgc cgagaactgt agtctgtaac gtaaacggca 1798981 cctcgtcatg gatgcgctgc accggatcgc ctccttcgtc ctgttcgaag gaggttcgaa 1799041 gcgactcgtg gcgcttgatc agctcttgga aagctctgtc catcctttca gggttgagct 1799101 tcccttcgag ctctaacaca gccggcatat tgtagcctgt ccctccgtcc tccagctgct 1799161 gaaggacata aatccgcttt tgggcagagg aaaccggata ggtttcctgt ttttcagcgg 1799221 gcttaatcgc ttcatatgga ctgtccgttc cttcacggat aacggtagcc agtccttcta 1799281 ccgtcggatg ggcaaacaca tcttttagcg gcacctgtac atcgaattct ttggtgatcc 1799341 gtgagacaag cgccgttgct tttaaggaat gtcccccgcg gtcaaaaaag ttgtcgtgaa 1799401 tcccgacagg gccatttttc agcacgtcct cccacagctg agaaagcttc atctcagtca 1799461 cgtttctcgg cgctgtgtag gtctccgcat ctgccgctcc gccaggagct ggcagggcgt 1799521 ttcggtcgag ctttccgctt ggcgtaaccg gccactgttc catctctatc atataggctg 1799581 ggaccatgta gcccggcaac agtctctcaa gctgcgctcg gacttcgttt ctttggagcc 1799641 cttctacata agcgcataat tccggctccc cgctgtctgt ccgtacggta acggccgcct 1799701 ctcttacacc ttctatactt cttagtgccg cttcaatttc tcccggctca atccggtagc 1799761 cgcggatttt cacctgatca tccgtgcgcc cgaggaattc aacattcccg tcagggagcc 1799821 agcgcgccac atccccggtt ttgtacatgc gttcacccgg gtaaaacggg tcttcaagaa 1799881 aacgctcctc cgttaatgcc ggccgattca aataacctct ggcaacaccc gctccggcta 1799941 tgtacagttc gccgatacat ccaacaggca gcatccgctg attctgattc aggagatata 1800001 atctgacatg atgaacaggt tttccaattg ggatccgttc aagtttttca tgcggcggac 1800061 aatcaaagaa tgcagcttct acggttgctt ccgttggccc ataggaattg gttattgaaa 1800121 catttggaag caactcgtaa aatcgggaga caagatgggt ccccagctgt tctcccccag 1800181 aaaacactcg cttgagtctg tttgtcttaa tcggtacaga gcgatatttt atatgttcta 1800241 aaaatgcatg gagcattgaa ggcacaaaat gcatagctgt gatcttttgt tcttctatgg 1800301 ccttcgcgat cacttcaggt tctttttcgc ctccctgagg aagcagataa acagaagctc 1800361 cggcataagg ccaccaaaac agctcccata ttgaagcatc gaatgaatat gatgttttgt 1800421 gcataatcat atctgaatgc tttagctgat agcgggactg tagggaattc aaaaaattca 1800481 ccgctgatcg atgttcaatt tcaacaccct taggcatccc ggtagagccg gatgtataga 1800541 tgacataggc taaagattgc gggagaacat ccacattcgg attggacaaa cgatgtgcca 1800601 gtccgctatt tgtctgattg agatagacaa tctctcctgt aaattccgga acatgaaggc 1800661 cggcagactg aagcaggaga atgtttgtac cgctgtcctc cagcagaaag ctgattcgtt 1800721 cttccggata atccgggtcg atgggcagat aagcgccgcc agctttaaga atgccataaa 1800781 tgccaagcag catttcaggt gaacgctttc ctataatggc aacagtcgtt tcgggtttta 1800841 ccccccgtcc gatcagctcc caggcgatac ggttagcctg ttcgttcaat tctttatagg 1800901 tcatcactcc atcttcgaag ataacggccg cctgatcagg cgttttttct gcctgctgtt 1800961 cgagtgcata gtggagcgtt tgattcattg aatagcccgt ctcctcaaac agatggcatg 1801021 attcaatgaa atctcgctct tcttcttttg ttaagattgg aatattgtcc aattctgttt 1801081 caggactggc agctgtatgt tccacaagcg tggtgaaaag gctggcccac ctttggatgg 1801141 tttctttctc aaacaaagct gtactgtatt caaactgaca gaaaagctcg gaatcatgct 1801201 ctgtaacgta tagggaaata tcaaattttg atattgggtg ctccaagtcg ttccactgaa 1801261 gctgtacatc attcattttt agcttttgct gttccatatt ctgaaggact agcgttgtgt 1801321 caaacaaagg attccggctc atttcccgct gcacaccgag tttgtccaca agctcttcaa 1801381 acgggtaatc ctgatgctca tacgcttcta gtgccgtctg tctgacttct ttcagaaatt 1801441 cctcaaatgt cttattaccc gccgggcgtg tgcggagagc caatgtattg acgaacatcc 1801501 caagaacagc ttcaaggtcg gcatggggcc gtccggcgat aggtgaacca atcacgatat 1801561 catcctgacc gcttaaccga gacaaaaagg ctgaatacaa agcgagaagc gtcatataaa 1801621 gcgtgcttct gtttttatgg gcgagccgct ttatgcgggc cgtgatctct ttgtccaatt 1801681 gaaaggttac ttttccgcct atgaattgcc gttctgccgg acgtcgttta tctgttggaa 1801741 gctccagtat aggaaggtcc ccgctaaact gctgctgcca gtaagtctcc tgcttttggt 1801801 acgagtctcc ctttttaaat ttctgctgcc atacggcgta atctttatat tggatccgca 1801861 atggcttaag ctgccggttt gcataaagat cggtaaattc tcggattagg agctgaacgg 1801921 atacgccatc tgaaatgata tggtgcatat ccaccagcaa tacatgcttc tcgtttgaca 1801981 cttctataag gcctgctcta aataatggcg cctggctgag atcaaaggga cggacaaatc 1802041 cctcgatagt ggtctcttta cttaacgtaa acggcacttc ggtgtggata cgctgaaccg 1802101 gctcgtcatc agctccggat acaaaggaag ttcgaagcgg ctcatgccgg ctgatcagtt 1802161 ctttacatac agcagacagt ttggcgacat ccagtgcacc ttccagttct aagaccgcag 1802221 gcatgttata ggcgacaccc tcatcaagct gttgaagcac atagattcgt ttttgggccg 1802281 aagatacagg atatgtatcc cttttttctg ctggttcaat tgctgcatac agattttgtt 1802341 ctgcctctcg aataattaaa gctaatcctt caacagtcgg atgagcaaag atgtccttaa 1802401 gtgaaacttg cacatggaat tcctttgcga tccgtgacat aagcactgtt gcttttaacg 1802461 agtgaccgcc attgtcaaaa aagttgtctt ggatgcctat atgcccattc tttagcacat 1802521 cttcaaatag ttgcgaaagc tttgcctcta acagatttcg aggggcagta tatgggtttc 1802581 cgctgattga agcatctggc tccggaagtg ctgcgcgatc tacttttccg tttggggtaa 1802641 gaggtatgct gtcaacccat atccatttcg ccggaatcat gtattctggg agctcactag 1802701 ccatataact gcgtaaatct attgtgttca gcttttgtac actgcaatag taagcgcata 1802761 attcatgttc accgttttga tcttgccaga tgagaatggc agcctcacta atgtccggat 1802821 gattcattag cgtgacttcg atttcttgcg gctcaattcg ataacctctg attttcactt 1802881 gattgtctgc ccgtccgata tattcgatgt tgccgtcttc aagccgtctg gccaaatcac 1802941 ctgtccggta catgatcaca tcaggcttga atggatcgga tgaaaatttg tcgcttgtca 1803001 gtttatcgtg attgacatat cctctggcaa cacttgcgcc ggaaatatag agttcgcctg 1803061 gtacgccgca tggctgaagc tgtttttgat gattcaaaat atatagatca gtacagccta 1803121 tcggtttacc gattggcgga agctcaggaa tagggtctcc aggatgaatg gtatacgtag 1803181 ataccacatg agtttctgaa ggtccgtaat gattgtgcag gtgtatgccg cgtttacgca 1803241 acacatcttg gaaaaggtct gaaatcatta attgttcccc ggctgcgatc aggtgtttga 1803301 cgccatcagg aaacgagttc gcaagttctc gctcgctgaa aatcattttg ataaaagcag 1803361 ttgggagaaa cacaatattc gtctgatgct tgtttataaa tgcaaacagc tgaggcacat 1803421 ctctttttat ggcttctggc acgatgtgga gtgtgccgcc tttcagaagc gcagaaaata 1803481 tttcttgata gcagacgtcg aaggaaggcg tcgcaaattg cagaacatct gcttcaaagt 1803541 caatgccgga gtgagtatat tcgaacttca gcaagttagc catgtttcga tgctcaaatt 1803601 gaacaccctt tggtttacct gttgtgcctg atgtataaat catatacagc agatcgtcag 1803661 cattgttgac tgactttatg ttactgccgt ctactttgct ttcgatatct tctggatgag 1803721 tgataatgta attgtcttct aacgatgagg gaagatgcgc ttgtgaaaca acatgcgaac 1803781 agccgcaatc atgcagaata taacggattc tgtcagcagg gtaatgcgga tcaaccggaa 1803841 caatggcgcc gcctgctttc aagataccaa gaacacctgt gataaacgcc gctgagcgtt 1803901 ccatcataat cgcaacgggt tcctgtctca caacgccttt cattcgtaaa tgccgtgcca 1803961 atctgttagc cgctttattc agttctctgt atgttaatga gcaggcttga tcaattacag 1804021 catgagcatc tggtgtcttt tccgcttgct tttcaaacat ggcatggatg gtttcgtaaa 1804081 ctggtgtttg atctgtgatt tctccaatca gctgccgctt ttcagtatct gtcgtgatat 1804141 cgatttcttc aggtggaaga ttcggattat ttaagatttg tgatacagca ttcagaagat 1804201 gctctttgac agagagcaca aaagaccgat cgtgctgctc cgcatcatag ttcattttga 1804261 tatgaatttc ttcccctggc gccaccataa gataaaagct gtagttggtt tcatctgcga 1804321 cagtgaaatt atgaatctga aaaagatcag aagcatgttc ctgtttgttc agcatttgaa 1804381 tctcttgctg caccggatag ttttcaaata cgagaatatg atcaatcagc ccttgcttaa 1804441 cagctgagcg ggattgaatc tcatataaag ggtggtagct gtacgcttca gcggcaagac 1804501 ggtctttttg catatctttt ataagttgaa gaaaaggcgt ttttgccccc tgcacccgaa 1804561 ccggcatcgt attaatgaaa agacctacca tatgttcaat gccttcgatt tctgcgggtc 1804621 ttcctgaaat gacagaaccg aatacggcgt catcgttatt attatatttt tgcagcagaa 1804681 tgccccaaat ggtatgaaaa atcgtactga gtgtcacttc ttctctagca gcaagctctg 1804741 aaagcctgct gctttcttcc ttagagaatg aaaatgtaac gtgttcctgc ctgctttttc 1804801 cctttgtttt tttctgcttc gggagcacgg tttgctgttc gtggccggaa agataatgat 1804861 cccaataaga aaccgcctgc tctttgtctt gctccatcag ccatttgata tactttccgt 1804921 atggctggac cggctccaat gttattgggg atgcatttac ataagatgcg taaatatgca 1804981 gaaactcctt tagcacaatg ctgaggcacc aaccgtccat catgatatga tgaaaggtcc 1805041 aaatgcaaga gtactggctc tctcctgttt gaatcagagc gatgcgcatg agcacatcct 1805101 tttgcaaatg aaacccccgg tcccggtcct tttctttcca ttgctcgata aactgtgatt 1805161 gctccgcctc gtttaaatga gtaatgtctt cttccagtac gatgacattt cgttctctca 1805221 gaacaacctg ctggggggag gaaacatttt ggctgataaa aatcgttctg aaaatatcat 1805281 gtctttctac aagagcgttg atgctgtttt gaaaaaactg cgggttgact tttccttcta 1805341 ttgtaaaaga agcttgctca acatacgcct gtgaatcttt ttgcaggagg gaatggaaaa 1805401 gcatcccttc ctgcatgtaa gacagcggat aaatatcctg aattgaattc gcttttgtca 1805461 tgttcatgtc tcctgtcacg attttctaca attcttccac caagctggat atgctgtcca 1805521 agtcctctgc cgttaatgat tgactgctga aatcgctcag tgtcttttct gctttctgtt 1805581 gaccggcgca gtgtttcata atgtccagca aaaagtgttc aatcctgtta ataagctgtt 1805641 ccattgtgtt tctgtgaaag cgggctggcg gataactaag attgaaatgg agctttttgt 1805701 ctgctgccat tgcactcatc tcgatgattt gctcgcgctt ccatgtatga gtgatatcct 1805761 ttccgctacc aaggcttgat gggcggaagg tgtcctgtct ttcgatgtcg ttgaactggc 1805821 ccaaatagtt aaagctgatt tcaggtgttt ttgaaaacgt aatgctttta ttttcagggt 1805881 gtgtaaggta tttcagcata ccgtaaccta cccctttgtt tggtatccgg cccagtgtat 1805941 ctttaacggt ttttactgag gttccgagct catccctatg attttcaaag cttatgaggg 1806001 ccgggtacat ggatgtaaac cagccgaccg tcctgcttat atctaactct ggcagaatgt 1806061 gttctctccc gtgtccttcc atagcgatac ggagcttgct tcctcctgtc cattcacaaa 1806121 tcgccaagga tgctgcggtt aacagaatat cttgtgtatc tgtgccatag gcgtgattga 1806181 cgttttgcag caagacggcg gtgtctgctt cagtcagtga aaagcttaat gagtcccttt 1806241 tgctgaagtc gatgttcaca tgatgcggta tttcataggg cagttctgcg gcttgctgtt 1806301 cttctacact tcgccaatac gcctcttcgc gaatcagctt actgctttgg gcatattcct 1806361 gtatgcgtct tgcgtattcc tggtaggaat ccgttttagg cggaagctgg atcgtctggc 1806421 ctgcagcagc ttgttgatat ccggctgaca aatcctccag caaaatccgc catgagacac 1806481 catcaacgac aaggtgatgg atcgcaagga acaagtaatc tccggtcagt gttttaaaca 1806541 aagcggcgtg caacaatggt ccttcctgca aattgatgct ttgctgaaga tcggcaactt 1806601 cttgtttgat tttcgtctcc cagccgcttt ctgactgtga aagatcagag attcttaagc 1806661 tgtatagctg tgactcatga atgccttggt tgatttgaat ccatcgcctg tcatcgttgc 1806721 gataaaccat ccgaagcgca tcatgatgct ccgccagttt tttcaaggct ggtctaaggg 1806781 cgttttcaga caaacgtcca gaatggaata gcatgacaga ctgattgaaa tggtgtcttt 1806841 cttcaatatc ttgtgaaaaa aaccattgct gaacaggcgt ccaaggaacg tcaccctgaa 1806901 tgggtccttg ctctatgatt ctctctgact tacggataaa tggtgataag tcctttatct 1806961 ttggatgacg gaataaatca cttacctgca agcttagtcc atagcgccca aggcgtgcag 1807021 aaacttgaag ggctttgatt gaatctccgc ccaattcaaa aaacgaatcc tctattccga 1807081 tcctctggat gcctagaacc tcctgccaga tcaatgccag ctgctcttca agttcgttgc 1807141 gtggcgggat gtatgtttgt ttagatgcga catctggttc aggcagtgct ttccggttca 1807201 atttgccgtt tgatgtgagc ggaagagtct ccatttcaat gatatacgcc gggatcatat 1807261 agtttggcag cgaacgcgcg agaagagaac gcacttgttc agcattcgtg cctgctttta 1807321 cgctgatata gccaaacagc tctttgctcc cggtctgggc tgtacgtgct aacactgcgg 1807381 cttctttgac cccgtctatt tgacgaagtg ctgtttcgat ttcacccagc tccacccgat 1807441 agcctctgac ttttacttga tcatcaatac ggccaacgta ctcaattgtg ccatcggaaa 1807501 gccagcgcgc cagatcacct gtgcgataca gtcgatcgcc aggtgcaaat ggatgtggga 1807561 caaatttctc tttcgttaaa tcaggacggc ccaaatatcc tctggcgacg ccatctccgc 1807621 cgacacaaag ttcaccgaca gctccgaccg gctgcagcac tccccattga tttaagataa 1807681 aagcggtgga attaccaacc ggccgcccga tcggaatgga aagttcatat gttttttgaa 1807741 tgtgaaggca tgtcgaaaaa gttgtatttt cggtagggcc atatccattc catatagata 1807801 cttcagggca gacatttctg attcgattga cgtggctcgg cgacaaagct tctccgccaa 1807861 taatcaaatg tttcagctgt gaaaatgttt gttcattttg ctctgtcaaa tgattgaata 1807921 gagaagatgt cagccaaatc gttgtgattc cttgatgttc tatgtacctc ttaagctgat 1807981 gggaatcgag aaatgtttgt tgatcggaca gatgcaaagc ggcaccattt agcagcggtc 1808041 cgaaaatttc aaatgaccca acgtcgaaac cgattgatga tgtcatcaga aggcggtctt 1808101 caggtgtaaa tgtaatataa ttgctgtttt taacaagacg aattacactt cgctgctcaa 1808161 tcatgacacc ctttggttta ccggttgatc cagaggtata aatgatatat gcaagtgaat 1808221 ggggccctgc tgaagattca acgttcttcg cctctccttg cttttgaata tcttcgatta 1808281 tgatttgttc acattcaatg cctaatagcc gtttttctgt tttttcagat tgaaggagta 1808341 atgctgccct gctgtcagac agcatataag ctatgcgttc aacaggcaga ttagaatcga 1808401 taggcagata ggctcccccg gcttttagaa tgcccagcat tcctgcaatg agttctggtg 1808461 ttctgcctgt caacaaggct acaacactat caggccctac gccctttatc tgtagaactg 1808521 aggcaatttg atttgcccag ctgttcaggt cctcgtaagt gaatacttgg gtgtcgctga 1808581 caattgctac agcattaggt gtttgttctg cctgcatttc aaagagtctg ctgatggttt 1808641 catttcttgg ataatctatt tttgtacgat tgagctcgtg gataaggtaa tgggcctcat 1808701 cctcattcag gatatttatt gttccgagag cggctttgtt gtctttgatg atggagagta 1808761 acatattgtt gaagtattga agccactttt ctatcgtttt tttcttatat aagtcagtac 1808821 taaactccat ttggaacgtc agcaaaccgc ggggctgttc ctgggcatat agggttaaat 1808881 caaatttgga cgtttgatgc ccattgtttg ctgcaggttt gagacaaagt tcatccagct 1808941 ccaacgattc ctgatccata ttttgaagaa caaacattac gtcaaacagc ggatttctgc 1809001 tcatatctcg tgtcaattca agcttatcaa caagctcttc gaacgggtaa tcttggtgct 1809061 caaaggcttc cattgctgtc tcgcgcactt cctgcaagta ctgtacaaac ggcttcccgc 1809121 cctccgggcg cgtccgaagc gccagcgtgt tcacaaacat gccgagtatc ggctcaagat 1809181 ccttgtgcgg ccggccggca attggcgagc cgacgatgat atcttcctgt ccgcttaagc 1809241 gtgacaagaa cgcggtgtaa gctgcaagga gcaccatgta cagtgtgctt ccgttttctc 1809301 gtgccagctt gtaaaggcct gatgtaacct cttgatccag cgtaaatgag accttgtcac 1809361 ccgcgaagct tcgcatcggc gggcgggcat gatcagccgg aagatccagc acaggcagct 1809421 cgccctcgag ctgcttcagc cagtacgccc cctgcgtttt gtacgcgtct cctgttttga 1809481 atccttcttg ccatacggca taatctttat attgaatgcg cagtgccgga agcttccgat 1809541 tattgtacag ttcgccgaat tcccgaatca gaatgttgac ggaaacaccg tctgaaatga 1809601 tgtgatgcat atcaaccagc aacaggtgcc gctcatctga tacctttacg atttgggcac 1809661 ggaacagcgg cgcttggctg agatcaaacg gtttgataaa tgcggctgcg gcctcctctt 1809721 cggttcgtgc gccgagaact gtagtctgta acgtaaacgg cacctcgtca tggatgcgct 1809781 gcaccgggtc gcctcctgcg tcctgttcga aggcggtccg aagcgactcg tggcgcttga 1809841 tcagctcttt gaaagctctg tccatccttt caaggttgag cttcccttcg agctctaaca 1809901 cagccggcat attgtagcct gtccctccgt cctccagctg ctgaaggaca taaatccgct 1809961 tttgggcaga ggaaaccgga taggtttcct gtttttcagc gggcttaatc gcttcatatg 1810021 gactgtccgt tccttcacgg ataacggtag ccagtccttc taccgtcgga tgggcaaaca 1810081 catcttttag cggcacctgt acatcgaatt ctttggcgat ccgtgagaca agcgccgttg 1810141 cttttaagga atgtcccccg cggtcaaaaa agttgtcgtg aatcccgaca gggccatttt 1810201 tcagcacgtc ctcccacagc tgagaaagct tcatctcagt cacgtttctc ggcgccgtgt 1810261 aggtctccgc atctgccgct ccgccaggag ctggcagggc gtttcggtcg agctttccgc 1810321 ttggtgtaac cggccactgt tccatttcta tcatataggc tgggaccatg tagcccggca 1810381 acagtctctg aagctgtgca cgcacttcgt ttctttggag cccttctaca taagcgcata 1810441 attccggctc gccgctgtct gtccgtacgg taacggccgc ctcccttacg ccttctatgc 1810501 ttcttagtgc cgcttcaatc tctcccggct caatccggta gccgcggatt ttcacctgat 1810561 catccgtgcg cccgaggaat tcaacattcc cgtcagggag ccagcgcgcc acatccccgg 1810621 ttttgtacat gcgttccccc aggtaaaacg ggtcttcaag aaaacgctcc tccgttaatg 1810681 ccggccgatt caaataacct ctggcaacac ccgctccggc aatgtatagt tcgccggcga 1810741 caccggaagg ctgtacggct aaatgcggat ctaaaacata caaacgcgca ccaggtacgg 1810801 gcttcccaat cggaatccgc aaacggtctc tgtcccgttc tggatctaac acgtaaaatg 1810861 ccgcgtctac cgtggcttct gtcggcccgt agccatggat taatgatacc tgcggcaata 1810921 cagaagcaaa acgggctgcc gtacgcggcg caagcggttc acctccggcg aatacacgct 1810981 ttaggcttgt cctgtcactc agcctttcga tttccgcttg atcgagaaag ctgttcagca 1811041 tagccggaat aaaatgagcc gttgtcacgt tttcctgatg aatggcttgt acgatcaatg 1811101 cggagtcttt ttcccagccg ggcggaagca gatacgccga agcaccggaa agagcccacc 1811161 aaaacagctg ccacacagac gcatcaaagg aaaaagaggt tttcaccatg acaatgtcat 1811221 cttccgaaag ccgaaactgg tgctgcatgc cggtcagaaa ggaaacagcc tggcggtgct 1811281 caacggccac tcctttcggc tgcccggtag agcccgatgt atagatgaca taggcgagag 1811341 atccgtcgct aacagaagca gacacatgac gttttacttc ttcacactca agagatgtca 1811401 tgtccacttc aagcgtttcg ccagaaaagt ttggtgcgga gcatcccggc tgtgtcagca 1811461 agagcgatgc cccgctgtct ttcagcatgt agctcagccg ctcctttgga tacgcaggat 1811521 caagcggcaa atacgcccct ccggccttca atacagcaag gacagcgatc agcatgtcag 1811581 gtgagcgttc agacaggaca ccgacgatac tttcgtttgt gacgccgcgt gccgcaaggt 1811641 gcgcagccag ccggctggcg tacatatcaa gctcagcgta tgtcagcgaa ccgcctgaaa 1811701 agcgaatggc cagccgctcc ggtgtgactg ccgcctgtcg ttcaaacagc ccatgcaggg 1811761 ttggggcttc aggtgaaaca gatactgtcc tgttattttg agaaacgatt ttccgtgttt 1811821 tgtcctcatc tagcaacgtc atctttgaca caggaagaga tggatcagag atgacgtcag 1811881 agaccatgtg cagcaaataa tcttttattt cggacatcat gcttggttga taagcgctgg 1811941 tctgaaaatg aatccgaacg tacaaggtac ggcctgggat cactttgaca ctgcaactat 1812001 aattggtcac ctcttccatc tcaaaatctt tgacggagaa atcaaatgac cccgcttgat 1812061 tcagctcttc gatctcttgc tgggtaggtg tattttcaaa gacgataata tgatcgatca 1812121 actcttgctt tagagcactc tgcgcctgaa tatcatacaa gggaaagtaa ctataggctt 1812181 ctgcctcatt catgtccttt tgcattctcc tgactaggtc agaaaaagac agagaatcac 1812241 tttgggctcg aataggaatg gtattgataa aaagcccgac catgttttcc acatctttta 1812301 gctcagaagg tctgcctgat ataactgaac cgaacacagc atcgctgctg cgattgacct 1812361 tttgaagcat aatcccccat aaagcttgga aaacagtgtt tagtgtcgca ccagaagctg 1812421 ctgcgatttt ctgtaattcg gcggtttctt tttcgggaat ggcaaacgtg atctgctgta 1812481 gtgtcccatt cggaatttga tctgttcttt tcggcagggg tgtagatttt tcgaaatgct 1812541 gaagcctctt tttccagtac tcagctgctt cttcacgatc ttgctgcatc agccatttaa 1812601 tatacgtccc gtacggctgt acgggaggca aatcaggaag ctggccttta cccagcgctt 1812661 gataaatatg gagaaagtct ttaatgacga tgcctaaaca ccagccatcc attaaaatat 1812721 gatggtggct ccagatacag acataatgat caggcgccca ttttaaaata gatattctca 1812781 tcagtacatc cgtttggaga tcaaagcctt tggatttgtc ctgctctttg aatgcctcgg 1812841 tacaatgttc tttatccctt tcattgagat gggaaatatc ttcaatatga atagggcaat 1812901 gacgttgctt gagcacgact tgacgaggtt tggctacatt tttatagatg aatgctgttc 1812961 gaaagatatc gtacctgtca aaaacagcat ccatactttt ttggaaacgc tccaagtcaa 1813021 gctgtccatg gatcgtaaaa gaagcctgtt caaaataagc tctcgactgt tcatcataca 1813081 gtgagtgaaa aagcatccct tcctgcataa atgacaaagg gtatatatcc tgtatttcag 1813141 gttgctgcgg catcagtgaa tctcctctcc tatagtttgt tgacggctcc catgatctca 1813201 ctcaattcat caagcgttaa gtcttcatca gtgaaatcag atgcgctcca ctcttggttt 1813261 tctttgccgg tacaatgctc aatgatgttt tccagagtct gtttaaaatg cctggaaaat 1813321 gtttggattg ttttttcctc aaattgaaac ctgttataga tgatgtgcat gttcaggcac 1813381 cccgaagaaa cggcgccgct gatatccagt gcataaggac gctcccagtt cgggctgatc 1813441 tcatttcctg gcttgatgtc agacacctca aaggcatttg attgaatatc ctgatcaaac 1813501 tggcctaaat aattaaagct gatttctggg ctgtttttct gagagcccca tcttttgctg 1813561 atatatttca gcacgccgta gcccgcgcct ttatgcggta tacggtgcag catatctttt 1813621 gtctgtttaa taaggtggcc cagccgctct tctttgtcct tatgatcgga atctctcata 1813681 tcaagccaca caggataaat ggaggtgaac cagccaacag ttctgctaat atcgatgtcc 1813741 tcaagatatg attcccttcc atggccctcc atgctgattt taaattggtt atttcccgtc 1813801 catttctgca aagcaagacc taaagctgtc agaaggatat cattcatctc cgtgctgtaa 1813861 gctttatgtg cagccgttaa tagtaattct gtgtgatggc gagatagctc aaaatcaatc 1813921 acttctgtat ctttgaatgt gttagatgct gcgtcattgt cttttggaat aggctggatg 1813981 tgacggttct cgcactcatc ccagtacgct gcttcgcgct gcacctggcg gcttatagag 1814041 tagtcagcta ttctttgtga atacgttaaa tatgaatctg ttttttgcgg cagtttaata 1814101 gattctcctg agactgcctg tttgtaagct gttgaaaaat cctcaaacaa aatgcgccaa 1814161 gaaaccgcat caacaactaa gtgatgaatc gttagaaata aatggtcacc attctcggtt 1814221 ctaaacaatc cagcgtgaag taaggggccg gtttccaaac gaatatgttc ttgcatccgg 1814281 ctggctgctt cctcaatcgt gttccgggct tctgttaggc tatcctttac atcaaacagt 1814341 tcaagtgcat atagctcctc atctgaaaga tctatccctc tgtttatctg cacttgcctg 1814401 ccatcttcat gccggcatac gattctcagt gcatcatgat gagtcacaag gctttttagt 1814461 acttttctaa gcgcagcctc atcaaatcgt tcagcccggt agatcataac ggattggtta 1814521 aaatgatggc tttccagaga ttgcgagaaa aaccactgct ggataggtgt ccaagtaatc 1814581 tcgccttcga ccgggccttg gtcaatggcg cgtacgtctt ttcgaacccg ggcggacagt 1814641 tcaccaagag tctgatgttc aaacatctca cgtactgtcg tttcaaatcc gcgctgcttc 1814701 agtctggcac aaacctgcag cgctttaata gagtctccgc caagcttaaa gaaattggcg 1814761 cttacaccca gctcatctac attaagaagc tcttcccaaa tttcagccat caccgtttca 1814821 atctcatttc taggactgat atcatcagct gtataagctt gtttttcagg ctctggcagg 1814881 gctttctgat cgagctttcc attaacagtc accgggatgc tgtcaatttg tatcatacgg 1814941 gcaggcagca taaagtcagg caaggcgttt tttaggtaag ttcggatgtc tgatatattc 1815001 gcagcctgtt gatcttttat caccatatat gcatatatag ctgtttgccc ttgctcgtct 1815061 gctctggtaa tgacagccgc ctctttaatc attggatact gaagaagtgc cgcttggatt 1815121 tcgcctaact caatacggtg ccctctgact ttcacctgct catcaatgcg gcctaagtat 1815181 tccagctcgc catttgacag gcgcttagca agatctcctg ttcggtataa tctgtctccc 1815241 ggaagataag gattggatac aaaacggtca gcggtcagct catctctgtt gagatatccc 1815301 cgtgccacac cttcgccgcc tatatacagc tcccctggaa ctccggtcgg ctgcaggttc 1815361 atatgggcat ccatcacatg agcctgcaga gtagaaagag gccggccgat attgctttta 1815421 ttttttgcaa tgtctgctgc ggacaatttt ttgaatgtta catggaccgt tgtttctgta 1815481 ataccgtaca tattaatcaa atcagtatga ggatattttt cattccagct ttgaagcaat 1815541 ccgggctgta aggcttcgcc gccaaaaatc acatagcgga tgtttaaatg atctgtatga 1815601 ttttggtctt caagcatcaa gccgtaaaaa gcagtcgggg tctgattgag tacagtgacg 1815661 cgctcttttt ttaacaataa tcggaatgct tgggggtcac gggctgtttc tttagagacc 1815721 acgactaatg tacttccgtt caataacgca ccgaacatct cccatacaga gaaatcaaag 1815781 caataagaat gaaataacgt ccagacgtct tcatggttaa attcaaaagg caggttttga 1815841 tgcttcaaga gactgatcac attgcggtgc tcgacaatga ctccctttgg ctgaccagtc 1815901 gttccagatg tgtatatcac gtatgcgggc tgatccgtta ctatttcttc aatgtttaca 1815961 tcagccggaa ttgagttgtt ttcacattca tcgatataca aaatatgccc ggtgtagtct 1816021 gcaggtttgt ttagaccgcg ctctgtcagc agcagttttg ctccgctgtc attgagcata 1816081 aagctaatac gctccttggg atattcagga tcaatcggca aataggcccc gccagctttt 1816141 aaaatcgata aaacgccaat gatcatatca ggtgaccgat cgagcatcag accgacgata 1816201 tcgccagttc tgaccccttg tttgatcagc atagcagctg cccgctcggc tttttcattc 1816261 aggtctcgat acgtaagctg agaatggccg cacaccactg cgatatgctc cggatactga 1816321 gctacttgct tttcaaataa gcttactatg ttttcatttc tcggataagc tgcatactgc 1816381 cccatttttt caaggagtaa cctacgctct gcagcaggaa gcaattgcat gttcgaaatt 1816441 ctcatctcag tatccgccgt tacccctttt accaattcaa taaaatagga tgcccactgc 1816501 gtaatggttt cttcttcaaa aagagcagtg ctgtattcaa aacggcagcg tattccactc 1816561 agatgctcct cagcatgtaa tgttaaatcg aatttagata tatcatgttt aggagtgaca 1816621 gacgaaatcg acagaccagg cacttcgaac cggaaatctt cactgctttg aagcacaagc 1816681 atcgcatcga acagcgggtt gcgatttacc tctcgatttg tatcgagctt atctgccagc 1816741 tcctcaaaag gataatcctg atgctcgtaa gcggtcagag ccaggtggcg aatgtcatgc 1816801 aaataggagc tgaacgtttt gtggccctcg ggcttgctgc gcatcgccaa tgtattgacg 1816861 aacattccga tgacgcgctc cagatcagcg tgcggtcttc cggcagcagg cgaaccgaca 1816921 acaatatcct cttgcccgct tagcttagat aacaaaatag aatagacagc cagaagaatc 1816981 atatacaatg ttgttcccgt ttcagccatt aaacggtgca gttcatcagc catgtcttta 1817041 tcaatgttga cttcaattgt tccacccctg aaatcaggga gacgcggcct tgttttatca 1817101 agcggtaatt ctagtgtagg aagactcccg ccaagctgac cgagccagta ggcctcctgt 1817161 tttttgtata gctctttcgg gtgcttctct tgctgccaaa cagcaaaatc cttataatgc 1817221 aggtttaaag ctggcaactc ttttccgcaa tataagtcag taaattcttg gacaagagtg 1817281 ctcatcgaga caccgtcggc aataatatgg tgcatatcga gcagcaaaaa gccgcgatta 1817341 ttgcccattg taatgacaca tgctctaaaa agcggaccgg atgatagata aaacggtttg 1817401 ataaaggtct cgattgcaga ctcaagcatt tgttctgatt ccatttcaag ctcttttaga 1817461 tcaaaagcca tctctggata aatgatctgc acaggctcgt ctctgtcaag cacaaaaaca 1817521 gtccgtaatg cttcatgccg attcacaagt tctgtgagaa cgcttctcaa ccgctggcga 1817581 ttcagatttc cgcgtaattc aagtacagct ggcatgttgt agcctgtgct gtcatctgcc 1817641 agctgatgaa gagcatataa tcgtttttgc gagaaagaca gcggatagac atctctttga 1817701 tccgcaggtt caatctgtgt aaaagcgtgt tcttttaagc tcatcaattt gaccgccatg 1817761 ctttcaaccg tcggataaga aaacacctca ctgagcggca gctcgacatt aagcttttta 1817821 tgtattcttg ataccagtgc ggccgctttt aaggactgtc cgcctaactg aaagaaatca 1817881 tcacgaatgc cgatgtgctg tttattcagc acatcttccc aaatatgtgc gagatcagct 1817941 tcgattaagg ttcggggcgc catatatgtg acactcgtat tgttttctgg ttcaggaagc 1818001 gcaaacctgt caagcttgcc gctggatgtt aatggcatct ggctgatgtt gataatactt 1818061 gctgggatca tataggacgg caatgtcccg gcaagatgct gatacaaatc tgggaggctg 1818121 tttccctttt ccggaacgat ataagcaacg agctcctttt cctcagcaga aacatcacgg 1818181 gccagtaccg ctgcttcttt tacccccggt gcttgtcgaa gaactgtttc aatctctctc 1818241 agttcaatac gataacccct aattttcact tgatcatcaa aacgtccaat atattcaatc 1818301 gttccatcag gcaaaaagcg gcctgcatca cctgttcggt ataaacgctc cccttcaagg 1818361 aatggatgat cggagaatgc tttctgtgtc agctcttgct gtttgtagta tcctctcgca 1818421 agacccgcgc cggaaataca cagttcaccc gccgcgccga tcggctgcat ttgatttccg 1818481 tgcaaaacaa atacttttgt gtttctgatc gggtgtccga tcgtgatcct ctctttttta 1818541 ttcagatgcc gcaatattgt tgttgccaca ctgttttctg tgggcccgta ttcatttgcc 1818601 agttcagcag aaggacaaat tatttgattc aactcaagca gatcaggcgt gaccgcttca 1818661 cccgcaaatg tcacaatacg aagacttttt gcatcgtcag cagtcatcac ttccaataac 1818721 accctgtaca gggaaggaac aatgatcatg tggctgacct tataacgggc tatttttcgc 1818781 ttaagggcca gcacatcctt cgcttcgtca tctgttgtca gcagtacgca cgcaccagat 1818841 aaaagcgggg taaataagct cgttacacag ccgtcaaaca cgtacgaaaa caaatggagg 1818901 gatatatcct gttcggtcat gctatactct tcccgtctcc attgcaatgt attggcaata 1818961 ccgtgatgat caactaaaac ccctttaggg cgccccgtcg ttcccgacgt atagatcaag 1819021 taggctagat cacctggcgg catatttggc gcttctgttt ggtaactttc tgtatgttct 1819081 atcgttatcg tatttccttc ataggacgga gggatcaagg aaataaggtc ttcttctatc 1819141 agcaattgag ccgcttgact gtccttcaga agaaaagaaa gacgttctgc tggaaaatgt 1819201 ggatcaagcg gcatataagc gccgcctgct ttccaaatcc caagcagagc tgcaggcatt 1819261 tccattgacc ggcccatcat tacagcaacg atatccccag atccaacgcc tttttctatc 1819321 agggcgtgcg caatctgatt ggctcttact tgtaactggc gataggtcca gcactcgttt 1819381 cccattttca atgcagcagc ttcaggtgtt ttgtgagctt gttcctcaaa caattggggt 1819441 atcgttttgt tcacataagg acgctcagtt tcgttaaaca attggataac ctgttgctcc 1819501 tccggcggca cgatattgat gtcactgacg gcaacatcgg gatttgtcaa aatgcaatcc 1819561 agtgcttgct ttagatgccc ctgaatcctc agcatctcct cccgctcgta aacgtctgcg 1819621 ttgtagctga atttgatata aaatgattct cccggaacga taacgatatt aaagtcgtaa 1819681 ttggtttgtt ccgacattga aatgtcactc agcttcagag cgccttcgtc attttcactc 1819741 tccacgctta atgcctgatg aagctgtaca gggtaatttt caaaaacaaa aatatgatcg 1819801 atcaaccctt gcttcaatgg actatggttt tgaatctcat aaagcggata atacccatgc 1819861 tgttcagatg ataaaatatc ctcctgcacg gctttgacca gcgaagaaaa tgttatgcct 1819921 tccgcagatc ggattcgcac tggaacagta ttgataaaca aaccgaccat tgattcaatc 1819981 ccgtcaatcg ctgacgggcg tcccgaaatg acggagccaa aaacggcatc atctgcagca 1820041 ttatatcgat ggagcagcac gccccaaata ctcataaaca gcgtgtttaa tgtcactccc 1820101 cagttttggg cagcctctgt cagtttctca accatatccg gcgctaatga aaagctgacc 1820161 tggtcggctt tataattccc gtctgccgtg cggcgcttta ttcggggaat agaagcagta 1820221 ttgccgtact ccttcaaata ttcgctccag taggcagcag tctcttcttg atcttgttct 1820281 ccgagccatt caatataacg gctgtacggc accgtgctgc caagctgtac aggtgagtta 1820341 tttttgagcg aatcatacat gctgaaaaac tctttaagaa taatgccgag acaccaccca 1820401 tccatgatga tatggtgatg tgtccagaca catgtatatt ggctgtctcc tctatcaaaa 1820461 agggcaagac gcattaaagg atctttttgc aaatcaaatc ctttttcccg atccttagtc 1820521 ataaaagcat caatcagcgt ctgctgttct tgatcagcca ggcgagaaat atcttctcta 1820581 tatactgtca attcacggtt tgatagaact acctgctgcg gacctgtaag atctggtact 1820641 tctttaatga aaatcgttct gaaaatatca tatctagaaa caagaaggtt taagctcttt 1820701 tgaaacgagt cgacgcatag attccctgtg atcgtaaacg aggtctgttc gatatatgct 1820761 ttcgagctga aatccattag tgaatgaaac agcattcctt cctgcatgtg cgataacgga 1820821 taaatatctt gaatttgtgc cgattgtgcc atcaattcca cacacctttt caaaagttaa 1820881 agatctttca cgagatcttc gatgctagat aatgcagaca acgttaattc tttattgctg 1820941 aaatcgctca atgttttttc gcgtgctttt ttctgcgaac aatgctcaat cgtctcgata 1821001 agatgcctgt gaaaacgatc cataaagcac tcaattgagt gtttgctgaa cacttgggtg 1821061 tataccgctt ttacgtgaag ccgtccgtcc gtaatgagag cattgatgtc cagctcatac 1821121 tctcgttctc tctcacccgc tatttcgtaa cggggctggt aatatgataa ttgaaacgtt 1821181 tcaacttcct tctcttcgct aaattgaccg agataattaa agctgacctc aggctcttta 1821241 tgccgcagtt ctcctatgtg tgttaacaat ccgtatccag ttcctttgtt cggtactctt 1821301 ctcagcatat cttttgtcgt cttaattcgg tatgcgagct gatcctcgaa aggctcggga 1821361 atacccatgt ctagcagaat aggataaatg gaggtaaacc atccaactgt ccttgaaata 1821421 tcaatgtttg gcacatgccc ttctctaccg tgtccctcag tgctgatcac gatttggtca 1821481 tgcccagtcc attcagaaag cgccattcct aaagccgtaa gcaaaagttc gttggcatca 1821541 gtaccatagg cttgctgggt ttcaaacagc aatttttcag tccagtcccc ggatagtaca 1821601 aacgctgctg cgtcgctgtt catttggagt ttgtctggca cattttctat gtccttagga 1821661 agaaaagcag tgtgagcgtc taaaatcgtt tgccaatacg ttttctctga aagcaattgt 1821721 ttactttcag ctatttgggt aagaccatcg gcgtaggata aataagaatc cgtttttggc 1821781 ggtaattgga tttctttctt ttctaaagcc tgttgatatg ctgcagctaa atcctcaagc 1821841 agaattctcc aagaaacgcc atctatcaca agatgatgaa gtgcaatcag caaatgatcc 1821901 ccttctgccg ttttaaacaa acctgcttgc agtaagggcc ctttttctac attcattttg 1821961 ctttgaatga cggtttcctc agcggcaagt ttttcatcaa gatgagccct ttccagcgat 1822021 gcttttgtcc aatctgaaat ataaaggcca aacagttcat gatccttgtg attgattccg 1822081 cgattaaact gaatgacatg gccgttttgg tcacgttgga aaatcatgcg aatggcatca 1822141 tgatgctcgg ttattttacg cagcgctaga tgaagcgcgt tagcattgaa tcctttttca 1822201 ctgaaaagca tgacggactg gttgtaatga tagtgaaaag catgtacctg tccgaaaaat 1822261 cttcgctgaa tcggggtgag ttcagcttca ccttccgcag gtccctggtc cgcttgagat 1822321 gccaatggtg tgatatgtcc gcatagttcc tgaatcgttg aataacggaa taagtcgcgt 1822381 attgtcatgc tccagccttc agctgccaga cgtgctgcca cttgtaatgc tttaattgag 1822441 tctccgccaa gctcaaaaaa ggaatcgtga atgccgactc gtgacatgct cagtacatct 1822501 tcccatatat acgccatcgt tttttgtaag tcgttaactg gtgcggtata tggacgcgat 1822561 aacacattat ttggagccgg caaggcattt ctgtccagct ttccgtttag ggtcagcggc 1822621 atgtttacta aaggaatcag atatgcagga atcatatacg ctggcagttc ctttgttaaa 1822681 gcagcacgga gagcattcgt attgacgtct gaaggcacaa tatatgctgc caaaccagcc 1822741 tgtccatttt tatcatgctg aacggcaaca gcagcttctc tgacaagccc cgtttgaagc 1822801 agaacacttt caatttcttc tgtttcaatt ctgtatccat ttatctttac ttgataatcc 1822861 attcggccaa gaagccggat cgttccgttt ggaagccagc atgctcgatc accggttctg 1822921 tacagccttt ctccagagac aaatggattt tctgtaaatt tcatttgcgt taagtcaggt 1822981 ttatgatgat agcctttcgc aacacctgcc ccgccgatgc acagctcgcc ggcaacaccg 1823041 atcggctgaa tttgatcagt ctggctgagt acgtacatgt gtacattcgg cagcgggctg 1823101 ccgattggta cgttatctcc cgtacactct ccacccatac tggtttcata gaaactcgaa 1823161 tcaatggttg cctctgtgac accatagcta ttaatgatgc gcatgctttg gccaaagcga 1823221 tctgtcaatg ttttgaaatc ttgagctttc accatgtcgg aaccaagaat cagtatgtct 1823281 aagtcaggaa gcttgaactg gttacggtat acatactcca tcaccgggat aatgagagcc 1823341 ggtgtcgact ccatcaccgt gattctctga gatttaatga ttttatatat ttcagcaggt 1823401 tccagccgtg tttcatctgg gcaaacgatt agagtcccgc cgttggtcaa tgttctcgcc 1823461 aaatctcctg agaagacatc gaatgaaaag ctcgcgattt gaagcagtct gacaggcttc 1823521 cgatccagtt cataaatttg acgccaagca agagcagcat gagtaaagtt ctgataggtg 1823581 acaataacac ctttaggcgc acccgtcgtt cctgacgtat aaatgatata taccggctct 1823641 tcaggagcag gagataagtt aaggttgcag ttactttctt caaaagagcc ctcatcgtca 1823701 aggaagatgt gagacatctc agattcaggc gagttcgaaa tcaaatgctt caactctctc 1823761 tgtaaaagaa gaatatctgc cccgctatca cgaagaatgt attcaatacg agcttttgga 1823821 taatgtgcat cgattgggat atacactccg ccagctttca tcactgccag aactccaaca 1823881 attgcatcga tggaccgctt ggctaaaaca gccacagttg gcttcggtcc ttttctgttt 1823941 tgcaatgttc gtgccagacg attggctctt tcatttagaa ggcgatagct aatctctgtt 1824001 tcgttatcaa taacagctat atgttctgga ttttcttcag ctttcgcttc aaatatgcga 1824061 tgaaaaggaa tatctttttg agcaaattca acttgagttt tgttaaattc aaagactatt 1824121 ttttgttttt ctttatcact aagtatgttt atttgtgcaa ggcttgtttc aggagttgaa 1824181 agtgcctcat gcagaaattc gataaaatga tcagcccagc gttcaatcgt agctttcagg 1824241 aatacttctg tactaaattc catttcgcag caaatagatc cacttatttc cgtagctatt 1824301 aatgtgatat caaataagga aatgtgatgt gcgaaattgg caggccggac ttttatttct 1824361 ctcagatcta tgtcttgttt ttccacattt tgaaggataa acatcgcatc aaacactggg 1824421 ttccggctca tatctcgtgt caattcaagc ttatcgacaa gctcttcgaa cgggtaatcc 1824481 tggtgctcaa aggcttccaa tgctgtctca cgcacttcct gcaaatactg tacgaatggc 1824541 ttcccgccct ccgggcgcgt ccgaagcgcc agcgtgttca caaacatgcc gagtatcggc 1824601 tcaagatcct tgtgcggccg gccggcaatt ggcgagccga cgatgatatc ttcctgtccg 1824661 cttaagcgtg acaagaacgc ggtgtaagcc gcaagaagca ccatgtacag tgtgcttccg 1824721 ttttcacgtg ccagcttgtg aaggcctgat gcaacctctt gatccagcgt aaatgagacc 1824781 ttgtcacccg cgaagcttcg caccggcggg cgggcatgat cagccggaag atccagcaca 1824841 ggcagctcgc cctcgagctg cttcagccag tacgcctctt gcgttttgta cgcgtctcct 1824901 gttttgaatc cttctcgcca tacggcataa tctttatatt gaatgcgcag tgccggaaga 1824961 ttccgattat tgtacagctc gccgaattcc cgaatcagaa tgttgacgga aacaccgtct 1825021 gaaatgatgt gatgcatatc aaccagcaac aggtgccgct catctgatat ctttacgatt 1825081 tgggcacgga acagcggcgc ttggctgaga tcaaacggtt tgataaatgc ggctgcggcc 1825141 tcctgttcgg ttcgttcgcc gagaactgta gtctgtaacg taaacggcac ctcgtcatgg 1825201 atgcgctgca ccggatcgcc tcctgcgtcc tgttcgaagg aggtccgaag cgactcgtgg 1825261 cgcttgatca gctctttgaa agctctctcc atcctttcag ggttgagctt cccttcgagc 1825321 tctaacacag ccggcatatt gtagcctgtc cctccgtcct ccagctgctg aaggacataa 1825381 atccgctttt gggcagagga aaccggatag gtttcctgtt tttcagcggg cttaatcgct 1825441 tcatatggac tgtccgttcc ttcacggata acggtagcca gtccttctac tgtcggatgg 1825501 gcaaacacat cttttagcgg cacctgtaca tcgaattctt tggcgatccg tgagacaagc 1825561 gccgttgctt ttaaggaatg tcccccgcgg tcaaaaaagt tgtcgtgaat cccgacaggg 1825621 ccatttttca gcacgtcctc ccacagctga gaaagcttca tctcagtcac gtttctcggc 1825681 gccgtgtagg tctccgcatc tgccgctccg ccaggagctg gcagggcgtt tcggtcgagc 1825741 tttccgcttg gcgtaaccgg ccactgttcc atctctatca tataggctgg gaccatgtag 1825801 cccggcaaca gtctctcaag ctgtgcacgc acttcgtttc tttggagccc ttctacataa 1825861 gcgcataatt ccggctcccc gctgtctgtc cgtacggtaa cagccgcctc tcttacgcct 1825921 tctatgcttc ttagtgccgc ttcaatttct cccggctcaa tccggtagcc gcggattttt 1825981 acctgatcat ccgtgcgccc gaggaattca acattcccgt cagggagcca gcgcgccaca 1826041 tccccggttt tgtacatgcg ttcccccggg taaaacgggt cttcaagaaa acgctcctcc 1826101 gttaatgccg gccgattcaa ataacctctg gcaacacccg ctccggcaat gtacagttcg 1826161 ccggcgacac cggaaggctg tacggctaaa tgcggatcta aaacatacaa acgcgcacca 1826221 ggtacgggct tcccaatcgg aatccgcaaa cgatccctgt cccgttctgg atccaatacg 1826281 taaaatgccg cgtctaccgt tgcttctgtc ggcccgtaac catggattaa tgatacctgc 1826341 ggcaatacag aagcaaaacg ggctgccgta cgcggcgcaa gcggttcacc tccggcgaat 1826401 acacgcttta ggcttgtcct gtcactcagc ctttcgattt ccgcttgatc gagaaagctg 1826461 ttcagcatag ccggaataaa atgagccgtt gtcacgtttt cctgatgaat ggcttgtacg 1826521 atcaatgcgg agtctttctc ccagccgggc ggaagcagat acgccgaagc accggaaagc 1826581 gaccaccaaa acagctgcca cacagacgca tcaaaggaaa aagaggtttt caccatgaca 1826641 atgtcatctt ccgaaagcgg aaactggtgc tgcatgccgg tcagaaagga aacagcctga 1826701 cggtgctcaa cggccactcc tttcggctgc ccggtagagc ccgatgtata gatgacatag 1826761 gcgagagatc cgccgtcagc aggagtaaac tcatggtttt ctgctttttc gctcgcaaga 1826821 gatgtcatgt ccacttcaag cgtttcgcca gaaaagtttg gtgcggagca tcccggctgt 1826881 gtcagcaaga gcgatgcccc gctgtctttc agcatgtagc tcagccgctc ctttggatac 1826941 gcaggatcaa gcggcaaata cgccccgccg gccttcaata cagcaaggac agcgatcagc 1827001 atgtcaggtg agcgttcaga caggacaccg acgatacttt cgtttgtgac gccgcgtgcc 1827061 gcaaggtgcg cagccagccg gctggcgtac atatcaagct cagcgtatgt cagcgaaccg 1827121 cctgaaaagc gaatggccag ccgctccggt gtgaaagctg cctgtcgctc aaacagccca 1827181 tgcagggtga aagctttagg cgaaacagct tccgtcttgt taaactcata caacaatttt 1827241 tgcttttctc ttgtattcgt catatctaat tctcttataa agctgtgcgg atgtttaagg 1827301 gcgttttcca gtatggtaag cagatgagat tgtattcgtt taatatcctc aagagaaaac 1827361 aaggtatttt gatagtcgaa atttaattga atggttccat tgtctatccg ttcttgtatt 1827421 tgaactgaaa gttcgttcgc ggtgtatccg ctgaaataaa gcgctgtttc atagtcaaaa 1827481 tcatctgcat tgtgccactg aagtggctga tactgcatag atataccgat aaggttgtgt 1827541 aaatccttct gttcatttct taattcattt acaagcaaat tataaggaaa ccgttgatga 1827601 cgcataacag aaagctgttc cctgcctatt gtgcggacaa aggaaagaaa atctgtgtca 1827661 ggatcaaccg ttattctgat tggaagggaa ctaacgaaca tgccgagcat ttctttttca 1827721 gcctttgaac ctctgttgcc atagtaggtg ccaatggcaa gatctttttt agaagtgatt 1827781 cggctgatgc atatgtaaaa tgaagccata aataaggaaa tgatattgat cttgtgttct 1827841 tcgcagaaga ttcgaatcgt ttgctctaga tcaggtgaaa gaatgatggt gtctctggat 1827901 gcagatgtgc tctgtttttg taaggacgtc tggtcggcta acgagtggta ttccaacggg 1827961 tgctcaaagg tttgcgtcca aaataaacgg tcctttgcaa accgtggaga ttgtagatat 1828021 tgactctctt tttcgatgta gctcaagtaa gaaggttccg gctgatcagg taaaggatct 1828081 ttctttttca ttttttgata aagatctata atttgatttc ccatcacatt taaagagatt 1828141 ccatccatta tgatatgatg gaatttcgca aatagccaaa cttcatgaga gtcaattcta 1828201 aggaggtaaa attgaaaaag aggcgagttg aacagtttaa atggaatgct cgcttgatcc 1828261 tgaatccatt gctctatttc tatcatttca acatttgaaa aatcaattat tctaagtgga 1828321 taatatttat attcagtaag gtgcaatcga ggctcaagct cttctccttc taacagctga 1828381 aatctaatgg cgtcgttgcg ggagatggaa tgattcagtg ctccctccag agtatcaagc 1828441 tcaatattgc ctttaaattt cacacaagct gtaagattgc aaatgctggt atctggctcc 1828501 agcagttcgg taaaccacac tctcctttgg gcatgggtta aagaataagt atgttcgctc 1828561 aacggattcc ctccagttct cataataaga ggataagaaa atgtagaaaa aagcagaaaa 1828621 atgacaataa aagaaattat atgactatat aatccatata tgcactatat taacggatat 1828681 tttttaaagt acaataaaaa acattaaatt tttataacat tttttttgaa tatagtatta 1828741 tttctttatt tttcgtttct ttttttatca aatttccgga tataaagtga taaaagtatt 1828801 gttttacata aggtcttata cactactttt taatcggact aattttcttt tgtgcatcat 1828861 tcttctaatt gttggaaggt tcgacaaagc gttattacag acataaaaaa acctgttttc 1828921 tcttggaaaa caggtctccc gctattattg atttgccaaa atgacagcga tttgatcctc 1828981 aatatctttt ccatcctctt catcaatcaa tccatttaga agaatagaga aaacaagttt 1829041 ttttccgctc tttgtttctg cgtaccccga tagagagctt accgtactga gcgatccggt 1829101 ttttgctctt acttttcctt gtgcaggagt gcctttcatg cggtttctca gcgttccgcc 1829161 caccattctg tcaggattcc ccgcaacagg taaagaattt agataagccg agaaccaact 1829221 ctgatcctga atgtcatata acagctgtga aagttgatct gaggatacag catcaatatg 1829281 tgagattcct gatccgtccc ttaagacgag tgatttagaa tcaacaccaa attccggaag 1829341 cgtactgttt aacacttcga gccccttttc ccagctccct tctccttttt tcactttccc 1829401 catctctttt acgagcactt cggcatgtcc gttattactt aatttcatga acggcacaaa 1829461 aagtttcgat aaaggcattg agcgatgaga gagcagcaca tctgaagaac taggtgcttc 1829521 acccgtcttg atgtcccctt tcacagtaat accttgtttt tttagtgact gcttaaataa 1829581 atctaaggca tatccggcag gctcccagac agaaatccat tcctttgtct tgtttgcgtc 1829641 aaccggtacg ctcccttcaa ttgtaatcgt gtttgttcca tgctctcttt cgattgtgag 1829701 gtctttctct gaaccggcag cagtcgtttt agcatcgttc tttatcgtta tataatcggt 1829761 tttcggagag acagacacgg caggctcttc cccttctttt tgatttgggg tgacctcaac 1829821 aatcacagtg cctgcatcat agtcttcgtt tggagacgct gttagagcgg agattggcgc 1829881 gccataatat gtgtattcat cgctccaagg catatcaggt gataatcgca tgtcatcatg 1829941 ccacgtatca tcaccgatca gattgccttt aattactttt acgccggaat gtttcaatat 1830001 ctcagccatt ttgtcaaaat cagatggtaa aagtgtcgga tcgcctttcc ctttcaaata 1830061 aaggttacca ttcagctttt tccctttcag tgttccatcc gtccggacct cggttgtaaa 1830121 agaatagttc tcgccaagga cagaaagtgc cgcggccgct gtcaaaagct ttagagaaga 1830181 ggcaggcctc attcgggtgt ctcctgaatg ttcatataga acagcacctg tttccgcaga 1830241 gcgaacggtg atgccggcca ttgcgccttc gagggcagga tgatcagcta aaatcttatc 1830301 gatctgcccg gaaagtgcat cttgtttttc agcggcaagc gcagcctgat gcatataagg 1830361 caccgaagca acgacgaaaa gcagtaaaac agcaacataa agctttatgc tttttttcat 1830421 taatttcccc gcctctctgc gcttcatcat tggctattga tgattcagtt caatggtgat 1830481 actgctttta gctgtcgttt cttctcccgg ctccagcact tgtaaaccag tgagtgacga 1830541 aggtaaatca agattcactg cgtttgtcac ccatgtgtaa ggctcagggc ataaataccc 1830601 ttgttttccg tccgcattgt atacaaccca atgtttaaac tgttcatctg ccttataaat 1830661 aatgctgata tgtgcatgct gatgataaat gactgcctgg ttttctccgc ccctcttctg 1830721 ataagaagat aaaaagacat catccagctg cttgtggcgc aaatccattc cttcatgcaa 1830781 agcttcttta tacgggacat ccatcagctt cccggtcggc agcaggcgtt catccaactc 1830841 ccattgctga tctgctgtca gggagaataa cgagctttct gccggaaata taaatgtagt 1830901 atgataacca attccccaag gaaacgcttc ctttcctttg ttcatgaccg tcgcatgttt 1830961 aaatagggta ttctccttga tcgtgtatgt catccgaacg acggcatgat gaggaaattg 1831021 cttctgcaca tggggaagct cagaaagatc aatttctgtt tcaacaatca ctccttcatc 1831081 agtttgcttc gtggtcacga cattccactt ttcatggtaa agaaacccgt gaagatggtt 1831141 gtgtttatcc ttctcgttga tatcaaaatg atacgttctg ccccggaaac tgaatgtacc 1831201 gtcacttatg cggttaggcg ggaacaggat tggaatgcca tacaatgttg gtgtgtcgtg 1831261 aaaactttct gctgtttccg gttcacgcaa aagctggaca tttgttgttt tgtccacgag 1831321 agaaatgacg ttgctccccc actcagggac aacaatcatt tctagatgtt cgttgcccgc 1831381 tttgatggcc ggcgttccca aatacgtgat tttctcaata aagtttgcca tgtttactca 1831441 acctctcctt gattcattgc tagtataaga attcaatgta ctgtaccata tttcctccat 1831501 tttatatttt cccctatcaa ataaaaaaac accgttcaaa cttatgaacg gtgtgattcg 1831561 gaggctattg gatgagacgt gtgatttgtt tctttttcca gacgaattga taatacccat 1831621 aaatcaacag caagctgacg gcaaacgcag ctggataacc aacccagacg ccgagtattt 1831681 caagctttgt atagtgagaa aggacgaaag cgacaggcac ctctactccc cagattgcaa 1831741 aaatactgat gacggtcggc cataaaactg ttccgcttgc ccgcatcgtt gcagaaataa 1831801 tttgggcatt tccaaacagc aaatagctcc acagtgtaat catcaaaaga cggtgcgcaa 1831861 tgtaaagcgt ctcttgctcg gttaaaaata acgataaaat ctgatgtgaa aaaacataga 1831921 tcagaatgat cagtacgccg ccaatgatat aattcagcca aatcccaacg cgaatgacct 1831981 gctttaagcg gtcaaactcg tttgctccga tcgattgcgc agcgaaaata gaaaccgcaa 1832041 taccaaggct gacggccggc atctgtacat agctggccac ctggttgacc actccgtatg 1832101 cagctgttgc attagagccg taatgattga cgaatgaaat aaccgctatc tctgataatg 1832161 agacaagaat catattgatg cttgctggga ccccaagacg cagcaggaga accagcagtt 1832221 ccttatccat tttcaaataa cgacgcactg ttttatcaaa ttgcagcggg tgttttcgct 1832281 ttcgtaaata caccattaac acgagaaaag tcgcaatcgt ggaaatgaca gttgcatatg 1832341 ccgagccgta tatgcccagt ttcggaaaac caaacatgcc aaggattaaa acaggcaaaa 1832401 gcgcgatgtt gatgaccgtg ctcacaatca gcgtataaaa cggtgtcttg gaatctcctg 1832461 ttccgcgcaa aaaggtagta tatgcaaaat ataaaaacat aaacggcata gcataaaata 1832521 aaatacgtgc atagttagcg ctgacatgaa tgacattttc aggtgttccc attaaacgaa 1832581 ggatatccag ggtgaaaata ctgccgataa cggctaacac aacgcctaat aaaaatgtaa 1832641 acgtgagtgt cgtcccgaca acagccttta gccgttcctc atttttcgct ccgtaagctt 1832701 gtcctatcag aatcgaactt cctgaaccga tcccaatcgt aaatgagatt aaaagaaaaa 1832761 ataacgggaa aaaggatgat acagctgcca ctgcatcaac accgagccat ctgcctacag 1832821 ccatcatccc gactagctgg ccgactgatt gcagcacatt gctcagcaga agcggcacta 1832881 aaaagagtga catcgaccgc caaactgatg gtttgctttt cttttgagtt acaagaggtt 1832941 cttgtgatgt ttccatatta aaggactcct ttatttgaaa tcgtttttaa acatgccctc 1833001 attttttgac aaaaacagga tatgtaacat gttattattc atcactgcac ttatgaaacc 1833061 cttcccgatt cttctaattt tacacatctt tttagcttat gaagaataaa ctagcaagta 1833121 atggcgtatt ttttgtgagt aaaagaataa aaaataattt atgcaaaagt attgtaatct 1833181 atccgtaatt attgtaacat ttgtaacata agagaaagag attttgaagg agagagcgat 1833241 aatgaaaaaa tgtcttctat ttctaacaac cattgcactt attctgtcat taagcacaaa 1833301 tgcatttgcg aaaaatacat caggcgattt atcacaaaaa caagcattac agttggcatt 1833361 atccgctaga gaacattttt ggaacaccat gagcggccac aatccgaagg tgaaaaaagc 1833421 agtttgccca tcaggcacat tcgagtatca aaatcttcaa tatgtataca tgtgcagtga 1833481 tctaggcact aaagcaaaag cggtgaatta tttaactcct atttttacaa aaacagcaat 1833541 cgaaaaaggc tttaaagatt atcatttcac tgtttcaaaa ggaaaacttg ctgttccaat 1833601 cggtgacgga gacaatcttt tgaattggaa aaaatcaact gctaaactga tctctaaaaa 1833661 aggcagcaca atcacatacg aatttactgt ccctacatta gacggatccc cttctgcaaa 1833721 acggaaagtg acatttgtga aagaaaataa aaaatggaaa gtcaatcaat ttgacgcagt 1833781 tatataagaa aaacgcccgg tataagcggg cgttttttat ttggtttgca taaagaaaga 1833841 caacaggcga aaagtgcctg ttgtcttttt gtgaatataa cgctctagga gagattcgaa 1833901 ctcccgacct gcagtttagg aaactgctgc actatccgct gtgctactag agcttttggt 1833961 atttatatag tagctctgat gatcaatatt ttcaagcgat ttgtattaaa gccctccaaa 1834021 aaccttatat gcggctcttg tcgtatcttc atcaataccg atataccgca ttgtaattga 1834081 tggtgatgaa tgattcagta ttctctgcag ctcggcgatg tctttcgttc gctgataaaa 1834141 atgatagcca aacgttttcc ggagtgtatg cgtccctatc tcctcaagtc cgcacgctgc 1834201 agcggcctct cttaaaattc tgtaggcctg aatgcgggaa atcggcttcc tggtccgcac 1834261 tgatttaaaa agatattcgt tttccttcat gtctttcgta tactcgtata tttcctgttt 1834321 cagcgattct aaaataagaa tctttctttt ctttttcgtt ttgctttcag tcgcccataa 1834381 atgatcttta ttttgaacgt ccttcacttg cagcggcaga atatcagaaa tacggagcgc 1834441 gctgttgatg ccgaaaataa acagaaaata atcccgcttg tttttgttaa gcaaatactg 1834501 tttgacttct tggattttct ctagactgcg aatcggctgt acaatatgca tcaaaaaact 1834561 ccttaaaaac cgttatgtaa cattttgagg tctatgttac tattatagct gaaaaacgtt 1834621 gaatgtcaaa gtgcggcggc gtttatgtaa cataatatac atagtgttac ataagctttt 1834681 aaaaaagctt cttccaacct tcaccctata aaataagctt taaagcctct tataaagctt 1834741 ttaacctctt ggatacttat ccccctacta atcatcaaaa aacctcttaa aatgaaatct 1834801 gacactccca attttctgga gcttccgcaa aaatatacaa aaaaagacac aatttcaaat 1834861 tgtgtcctaa tcctcatcct ttacatcaat atcttccggg atcggttcat ttaatatttc 1834921 ctgcacaagt gctttgtaat tctccagctg ttcgagatgc gttttgaact gttccttata 1834981 aatcaaaaat tgctccccgt catgaacggc tctgattttc ccttcgagca ccaagctttt 1835041 aatataatcc tctgaaagat ttgtatattc tgctgtttct tcaatcgtta aatacatata 1835101 gcagtccctt cttaatccgt atgctgattc taatatagca catggctcat atcaatataa 1835161 tcaattctgc acagaaaaac ggcattatgc actatataat ataccatttg tcacttgtga 1835221 aaacgctgta atttttttac gctaagattg taacaataca gcttcatata ggagggagaa 1835281 catgaaaaga acgtggaacg tctgtttaac agctctgctt agtgttctgt tagtcgctgg 1835341 aagtgtccct tttcacgcgg aagctaaaaa accgcccaaa agctacgatg agtacaaaca 1835401 agtagatgtt ggaaaagacg gcatggttgc gaccgcacat cctcttgctt ctgaaatcgg 1835461 tgctgatgtg ctgaaaaaag gaggaaatgc tattgacgca gcggttgcca ttcaatttgc 1835521 actcaatgta acagagccga tgatgtcagg tattggcggc ggcggtttta tgatggtgta 1835581 tgacggaaaa acgaaggata caacgataat cgacagccgt gagcgtgctc cagcaggcgc 1835641 aactcctgat atgtttctgg acgaaaacgg caaagcaatt cctttctctg aacgtgtaac 1835701 aaaaggtact gccgttggtg ttccaggcac tctgaaaggg ctggaagaag ccttggataa 1835761 atggggaacc cgttcgatga agcaattaat taccccttct attaaactcg ctgaaaaagg 1835821 ctttccgatt gattcggtgt tggcagaggc catttctgat tatcaggaaa agctttcacg 1835881 gactgccgca aaagatgtat ttttaccaaa tggcgaaccg cttaaagaag gagataccct 1835941 tattcaaaag gatttggcta aaacatttaa gcttattcgc tccaaaggca ctgacgcttt 1836001 ttataaagga aaattcgcca agacgctttc tgacactgtc caggatttcg gcggatcaat 1836061 gacagaaaaa gatttagaaa attacgacat tacaattgat gaaccgattt ggggagatta 1836121 tcaaggctat caaatcgcta ctactcctcc tccaagctcc ggcggtattt tcttattgca 1836181 aatgctgaaa atccttgatc attttaacct ttcacaatac gatgtccgct catgggaaaa 1836241 atatcagctg cttgctgaaa cgatgcattt gtcatatgcc gaccgtgcgt cttacgcagg 1836301 tgatcccgaa tttgtaaatg ttcctctcaa aggcctgctt caccccgatt atattaaaga 1836361 acgccagcaa ttaatcaacc tagatcaagt gaataaaaaa ccgaaagccg gtgacccttg 1836421 gaaataccaa gaaggatcag caaactataa acaagttgaa cagccgaaag acaaagtaga 1836481 aggccaaaca acccacttta cagttgctga ccgttgggga aatgttgttt cttatacaac 1836541 aacaatcgaa cagctattcg gaacgggtat tatggtccct gattacggtg ttattttaaa 1836601 caatgaatta acggattttg atgcgatacc aggcggagct aacgaagtac agccaaacaa 1836661 acggccttta agcagcatga ccccgacgat tttatttaag gatgacaagc ctgtcctcac 1836721 ggttggatct cctggcgggg ccacaattat ttcatccgtt ttgcaaacca ttctctacca 1836781 cattgaatat ggtatggaat taaaagcagc tgttgaagag ccgagaattt acacaaacag 1836841 catgagctct taccgttacg aagacggagt tcctaaagat gtcctcagca agctaaacgg 1836901 catgggccac aaattcggca caagtccggt ggatatcgga aacgtgcaaa gtatatcgat 1836961 cgaccatgaa aacggcacct ttaaaggtgt agctgattca agcagaaacg gcgcggcgat 1837021 cggcattaat ttaaaacgta aataaataaa aaactgtact cgcttcaaat gagtacagtt 1837081 ttttcatgca gatctttaaa ataaaaactg acaaacgtct ttattctgct aatgcacgtc 1837141 tatcttcatc ttttcatttc gtttatctca tcaagaaatg tctgaaacgc actcgtaata 1837201 aaaaagtctt tcctgtatat aaagacgatc tctaagtctt gatatgatgg tggcagctga 1837261 tgaatccata catttgtacg atgctcggag ccgtcaacag cggactttgg gagcagcgcc 1837321 gtacccatcc cggcggaaac accttttata atagcctcca atgtgccaaa ctctatgatt 1837381 ttttgattgt gtatgcctgc ttcctctagt aatcttttga ccctgtcacg atgagaacag 1837441 ccagccccaa aaaagagcat cggctgctga agcatgtctt ctgccgtccc ttctcgtgat 1837501 gaaatcaaaa ctaattcatc atgggagaca tggagttgtc taactgcagc gtgttcaacc 1837561 ggcccatata caaaagcgcc atcaacttta tgatcaagaa cctgttgaat caaatgatgc 1837621 gtatcagctg tgttcactga taaatccact tcaggaaaac gcctgaggaa ggatgctgca 1837681 tgctcaggca gatgcgttac cgccattgtt tccagtgatc cgatccgcaa aggccctttt 1837741 ggttgcctgc tcattcgggt cgatttttca gcttggtcta acagcgataa tacttgatct 1837801 gcatattgta aaagattttc tcctgcagca gtcagcttca ttccccgatt cgttcgatga 1837861 aaaagcctga tattcaaatc ttcctcaagg ttatgcactc tggctgtcac attcgactga 1837921 acataattca gcatttgggc tgctttcgtt atgcttcctt cgcgagcaac agcctgaaaa 1837981 atctttaaat ctccgctttc cacgcgctct cacctgcttg ctatgatgaa aagtgatatt 1838041 ggctatcata tttgttcatt ttactcgaag aaaaccgcta tgtaaaatat gtaaagatat 1838101 gaaaatacaa ttaatgagga ggcagacagc atgaaagctg taattcacaa cggaaaagcc 1838161 ggtcttctgg ggttatcagt tcaggacgtt ccatcaacaa agcctggata cggagaggta 1838221 aaggttaaat taaaatctgc aggcctgaat catcgtgact tgtttcttat gaaaaacaaa 1838281 tctgaacaag atcctcacat gatactgggt tctgacggcg cgggtatcat cgaagagatt 1838341 ggtgaaggcg tgaaaaatgt tactgttcag acagaagtag tcattttccc gacattgaac 1838401 tgggatttga cagaaaatgt tccacctgta cctgagattc tgggaggtcc ttcggacgga 1838461 acacttgctg aatatgtgat cattccttca caaaatgcaa tcaaaaaacc tgcttattta 1838521 tcttgggaag aagcgggcgt tttaccttta tccgctttaa ctgcatatcg ggctctgttt 1838581 acaaaggggc aattaaaaaa aggcgagcat ctattgatac ccggcatcgg cagcggtgta 1838641 gcaacctacg ctttatttat ggctaaggcg attggggcaa cagtaagcgt gacctcccgc 1838701 agtgaggaga aaagaaaaaa ggcgctgaaa ttaggtgctg attacgcatt tgacagctac 1838761 agcaattggg atgagcagtt gcagggaaaa aagatagatg ttgttcttga cagcatagga 1838821 cctgccctct tttcggaata cttccgccat gtaaaaccaa atggccgtat tgtcagcttt 1838881 ggggcaagct caggggataa tctcagtttt ccggtgcgtt ctttattctt tcctcaggtc 1838941 aatgttttgg gaacctcgat gggaagcggt gaggaatttc aagctatgct cgctttcatt 1839001 gacaaacata agctgcggcc tgtaattgac cggatatatc ctttagaaaa agcatgtgaa 1839061 gcatataaaa gaatgcagga aggcagacag tttggaaaca tcgggatcgt aatggaataa 1839121 aaaaagaaac cggctggcag ccagaccggt ttctcttata tgataatccc ctttatttac 1839181 ggaagaactg aactccccat caaatatcga tccacttcac gcgccacttc acggccttca 1839241 ttaatcgccc atacgattaa gctttgccct cttcttgcat cccctgcggc gaatacacca 1839301 tcgatatttg tttgataatc cccatatgct gcactgattt tgttatttac tgaattaaca 1839361 ccgaactgtt tcaacagcgg ctgttctgtg ccttcaaagc cgatagcgat aaagacaagc 1839421 tgagcaggcc atactttttc cgttccaggc agctcgcgga actcgtattt tccatgctca 1839481 tttttcactt tttccatttg gatggtatga agctctttca gctttccgtt tttatccgcg 1839541 accatttttg tcgtttgaat ggagtattct ctcggatctc ttccgaattt tgcttctgct 1839601 tcctcgtatg catattcaag cgtaaagacg tgtggctgtt caggccacat attgtcattc 1839661 gtgcgggctg gcggaagttt cgggtgtttg ccgaattggt gcacgctttt ggctttttga 1839721 cgcagagcgg tagccacaca gtcagctcct gtatctccgc ctccgattac gatgacatct 1839781 ttccctttgg catcaatgaa ttgcttgtct ttaaaattag aatctaaata gctttttgtt 1839841 gcaagtgtga ggtagtccat tgcgtaatgg actccttttg agtcgcgtcc ttcgattaag 1839901 aggtcccgct gtttttgagc gcctgtgcat aagatcacag catcaaattg ctcctttagc 1839961 tcatcagctg taatgtcaac accgatttct gtgttcgtga caaaatcaat tccctcttgc 1840021 gtcagcaatt taattcggcg ttctacaatg cccttctcaa gcttcatgtt tggaatgccg 1840081 tatgttaaaa ggccgcccgc tctgtctgct cgttcaaaaa cagtgacgga atgtcccgct 1840141 tgattcagct ggtcagcact cgccagtccg gctgggcctg acccgacgat ggccactttt 1840201 ttgcctgttc gtttttttgg aattctaggt tgaatccagc cgttctcaaa tcctttatcg 1840261 ataatggtcc gctcgatgtt tttaattgat acggccggat ctgaaatcgc taaagtgcat 1840321 gatccttcac aaggagcggg gcatacccgc cctgtgaatt caggaaagtt gtttgttttc 1840381 aacagacgtt ccaatgcttc cttccatctg ccccggtaga caagatcatt ccattcagga 1840441 attaagttgt aaatcggaca gccggatgta aatccgttaa tgtccgcacc gatctggcaa 1840501 aacggtgtac cgcaatccat acaccgcgcc ccttgccgtt tcgatgcttc ttctgaaaaa 1840561 ggagcagaat attctttcca atcctttaag cgagtgagag ggtcccgctc cgcaggtttt 1840621 tctcgtttga tctccataaa tccagttggt ttccccatgt tcctctcccc ttccttactg 1840681 tactaccgct tgtttttgtc ccgatgctgc tgtattctgc tttggcttcg tgttggcctc 1840741 aaaagcgaac atgatggctt cttcatctga taaacctgca gctttttgct cttcgatgct 1840801 tgcgagcatt tgtttatagt ttttcggaat gactttgacg aattttttca cactgtcttc 1840861 ccattgatct agcagatctt ctgctttttg gctgtttgta tacgcagtat gtctttcaag 1840921 cattgctttg atttgctgga tttctttctc atcctctaat gattcaaata aaatcatctc 1840981 aaggttgcat ttgcgtttaa acgctttgac atcttcggtc agtacataag cgattccgcc 1841041 ggacatacct gccgcaaagt ttttgcctac atcaccgaga acgacaacgc tgccgccagt 1841101 catgtattca cagccgtggt cgccgatgcc ttctacaact acgttcacac cgctgtttcg 1841161 aacggcaaag cgttcaccag cacgcccgtt aatatatgct tctccgcttg tcgcaccgta 1841221 aaaagccacg ttgccgataa tgacattgtc atccgaagca gagttgaatc cttctgatga 1841281 cttgacgatg atttttccgc cagaaagccc ttttccgacg taatcatttg agtctccgtc 1841341 caaataaagc gtcatccctt taggaacgaa agctccaaag ctttggccgg ctgatccggt 1841401 aaagtgcagc ttgattgtat cttcaggaag accttcttct ccgtaacgct ttgagatttc 1841461 actgccggtt atcgttccgg ctacacgatt tgtattattg atttcaatcg aaatatcagc 1841521 ttcttttcca gattcgatgg cttcttgtac ggccgggaga attgttgtaa tatcaagtga 1841581 ttgatcaatt ttatgatttt gcggcgattg gaacgtccgc accccttcag gctgataaag 1841641 aagggtagac aaatcaagct ggcttgcttt ccagtgctcc tttgcccgtt cacttgcatg 1841701 aagtacatca gtgcggccga tcatttcatc aaatgtcttg aagcctaacg cagccatgta 1841761 ctcacgaact tcttcggcaa tgaacagcat atagttcaca atatggtcag gatctcccat 1841821 gaactttttg cgaagctctg gattttgtgt cgctacaccg acagggcatg tatccaaatg 1841881 gcaggcacgc atcatgacac agccgagtac aactaacgga gccgttgcga aaccaaattc 1841941 ttcggcgccg agcaaggcag ccatcacaac gtcgcggccc gtcatgagct ttccatctgt 1842001 ttctaataca acacggtcac gaagtccgtt cagcattagt gtttgatgtg cttctgcaag 1842061 gccaagctcc cacggaagcc ctgtatgttt aatactggtt ttcggagaag cgcctgtacc 1842121 tccgtcatag ccgctgatca caatgacatc tgcagtcgct ttggcaacac ctgcagcgat 1842181 tgttcctaca cctgcttttg acaccagctt tacgctgatt cttgcgtcac ggttggcatt 1842241 tttcaaatcg tggatcagct gggctaaatc ctcaatcgaa taaatgtcat ggtgtggcgg 1842301 aggtgagatt aatccgacac ctggcgttga cccacggaca tcggcaaccc atggatatac 1842361 cttgttgcca ggaagctgcc cgccttcacc cggcttagca ccttgagcca ttttaatctg 1842421 cagctcatca gcattgacga ggtaatggct tttgacacca aaccgtccgg atgcaatttg 1842481 tttgatcgca cttcttctat catcgccgtt ctcatctgga acaaagcgtt tgggatcttc 1842541 tccgccttca ccgctgttgc tttttcctcc aagacggttc attgcgattg ctaaagcttc 1842601 gtgcgcttcc ttactcaagg acccgaatga catcgcaccc gttttaaaac gtttgacaat 1842661 cgattcagcg gattcaacct cctccaactt caaaggcttg cggtttccgt caaatgcgaa 1842721 caagttccgc aaaaatccga tgcgttcttc atcagccgct tttgtatact gtttaaacag 1842781 attgtaatca tttctgcggc acgcccattg caaagtatga atcgttttcg gattaaacgc 1842841 atgatgctct ccgccatttc tccattggaa gtcacttccc ggttcaagcg ttttgctgta 1842901 atcatcctga tacgcttccc ggtggcggcg ctgtgcctct tctgcaattg tttgtaaatc 1842961 gatgccgcct agctgtgatg cagtacctga gaaatagcgg tcgatcacat cgcggctgat 1843021 tcctaccgcc tcaaagattt gtgcgcctct gtagctttgc acagttgaaa ttcccatctt 1843081 ggacatcact tttacgacgc cctcagtaat gctttttcca tatttgctaa ccgcttcttc 1843141 atagctgata tccaaacggc cttcatcaat ttcctgcttg taggtcgcat aagcgagata 1843201 agggttaatc gcatctgcgc cataaccgat taacgctgca aagtgatgca cttcacgtgc 1843261 ttctcccgat tccacaataa tgctgacctt cgtacgcagc cctttgcgga ttaagtgctg 1843321 gtgcagtgcg cttactgcca gaagcggcgg aattggtgtc agtcgttcgt tcatcttttt 1843381 gtctgataaa attaacaaac ttacgccttg gctgatggct ttctctgcct gtgtgaacat 1843441 gtcctttaaa ccgcgttcaa gatcctctga aaacagcaca tcaatttttt ggctttttaa 1843501 atcaggatga acaatcgttt tcaatgcgta aaactgttca ttggataaaa caggtgtata 1843561 cagtttaatc cggcgaacat ttcgttcact tggatgaaga agatcgcctt ccgcaccgag 1843621 ccaagtcatc gttgaagtga caagctgctc acgaatcgcg tcgattggcg ggttcgttac 1843681 ttgtgcaaac agctgtttaa agtagttaaa cagcgattgc gctcggtcag aaagtacagc 1843741 aagcggagcg tcattcccca ttgaaccaag gggatctttg ccttctttaa taacaggaat 1843801 tagatacttt tggatatcct catatgtgta tccgaatgcc ttctggcgag taagaagatc 1843861 actaaattgt tcttcttctc ttgactccgg atcaggattt acttgtacaa gctcttcttc 1843921 aagccatttt tggtacggat actcagttgc aatttgtgtt ttgacttcct catcggagat 1843981 aatacggcct tcttccaggt cgattaaaag cattttccca ggctcaaggc ggtttttata 1844041 taaaacgttc tcctgttcaa cttcaataac gcctacttca gatgagaaaa taatataatc 1844101 atcttttgtg acataataac gggccggacg gagaccgttc cggtcaagga tcgccccgat 1844161 ttgtttaccg tcagtaaatg aaatagctgt cggtccgtcc caaggctcca tcagggagct 1844221 atggtactcg tagaacgccc ttttttcctt ggacatatgc gtattttccg tccaaggctc 1844281 tggaatgagc atcattgccg tatgtgccgg tttgcgtcca gccatcacaa aaaactcaaa 1844341 tgcgttatcc aaaatggaag agtcactgcc atcagcattg agaatcggca aaatcttgtt 1844401 taagtcctca ccgaagcttt cagaaacaaa ttgctgctca cgtgctctca tccagttgat 1844461 atttccgcga agggtgttaa tttcaccgtt gtgaaccaaa tagcggttag gatgcgctct 1844521 ttcccatgta gggaatgtat tggtactgaa gcgtgaatga acaagcgcaa aagcagaaac 1844581 gaatgcttcg tcttgcagat cagaataaaa tgcatcaacc tgttcaggtg ttaaaaggcc 1844641 tttgtaaaca atggtctggc ttgaaagact ggcaaaataa aaatcaagac cttccgttac 1844701 tccccaattt tcagcctgtt tacgaatgac atacaatttt cgttcaaaag ataaattgtc 1844761 ctttagatca gaacttgcgc cgataaatac ctgacggaca aacggacagc ttttttgcgc 1844821 cactgttccg atttttccga catttacagg tacagttctc catccaagaa cgacttggcc 1844881 ttcttgttca attagtgcat tgatttgctt ttcaattttt tttctttcat cttccttctg 1844941 tgagaaaaag accattccta ccccgtaacg ttctttttct ggcagattga tgtttttgca 1845001 ctcttttcta aagaaagcat cagggatttg aaccagtaag ccggctccgt ctcctgtatc 1845061 cggatcactg ccttgccctc ctctatggtc tagctggcaa agcatcttaa gtccttgttt 1845121 gacaatgtcg tgagtctgct tgccctttaa gtgtgcatat aggccgattc cgcatgcatc 1845181 atgttcaaat tcaggacggt agagaccttg agcttttggc atttgattgt acgtcataat 1845241 tcctctcccc cgatcaattt ccgataatac cggtcataaa atctaacaac tctataatca 1845301 ttgtaggttt tcaaaacgat ataaacaata tataatttag atcaaaagaa tctcaaaatg 1845361 agatagatgg atgtgagaca aacatggagc tgcgccaact gcgttatttt atggaggtgg 1845421 ctgaaagaga acacgtttca gaagccgctg atcatttgca tgtggcccaa tcagcaatca 1845481 gcagacaaat tgccaatctt gaagaagaat taaatgtgac cttatttgag cgtgaaggga 1845541 gaaatatcaa actcacgcca atcggaaaag aatttttaat tcatgtgaaa acggcgatga 1845601 aagccattga ttatgcgaaa gagcaaattg atgagtatct tgacccgcat cgcggaacgg 1845661 taaagatcgg ctttcctaca agcctcgcca gccagctttt gccgactgtc atttcagcgt 1845721 ttaaagaaga atatccgcac gtcgaatttt tgctgcgcca aggctcctat aagtttctga 1845781 ttgaagctgt cagaaaccgc gatattgatc tggccttatt agggccggtg ccgacgaatt 1845841 tctctgacat aacgggaaaa atattattta ctgaaaaaat ttacgcgctt gttccattaa 1845901 atcatccgct tgctaaacaa aaaacggttc atttaatcga tttgcgcaac gaccaatttg 1845961 tattgttccc ggaaggattt gtacttagag agatggcaat cgatacttgc aaacaagcag 1846021 gctttgctcc tctcgtttcc acggagggtg aggatttgga tgcgatcaaa gggttagtgt 1846081 ccgcaggaat gggcgttacc cttctgcctg aaagtacttt tgctgaaaca acacctcgtt 1846141 ttactgtgaa aattccaatt gagttccctc aagtaaaacg gactgtcgga atcattaaac 1846201 cgaaaaatag agagcttgcg ccttccgcga atgattttta tgagtttgtc attcaatttt 1846261 tctctaagct ggagcagtat caataaaaaa aatgaacccg agcttctata tagaagcttc 1846321 gggttttttt ctgcaaatta atttacaggt aaagaaaaat ccacatggca aacaaatgct 1846381 tcttgatcaa ttagagctct atttgtcagt tcctttttct tttccggttc ttgaagctgt 1846441 acagaagagt aattgacgat tccaaggccg atttccgtcc cttttgaatc catcagccga 1846501 acaactgaac cgcttttgaa tttcccttta atcttctgta caccgtctag gtataaactc 1846561 gattgtccgt ttgttatttt tcgtgaacaa tcatctgata aaatcatttc accttccgga 1846621 ccggaattaa aagcgatcca ttgctccttt tgattcaacg gaagcgttcc ttctgcttca 1846681 aaataggtgc cttccgcctg ttcatgaacg gcgtggtata aaatatcgcc agcatctgcc 1846741 tgacctagga aacctttaat gccagacgcc attacgattt taaacgcatc aagcttagag 1846801 cgcatgccgc cggtgccaac gatgcttcca gtgtcacctg cgcatgcttc gatgtcaggt 1846861 gttatttcac tcacccgctg tatctttttc gcttctggat ttgtgcgcgg attgccgtca 1846921 tataatccgt ctatatctga taaaatcaca agcatatctg catcaatcaa tcctgcgact 1846981 tttgctgcga gcgtatcatt gtcgccaaac ttgagccgat tgacggtaac tgtgtcattt 1847041 tcgtttatga tcgggatgat gccgcgctcg agcagtacat tcattgtatt cctgacattg 1847101 ttgtatcgat attcatcaga aaaatcgctt ctcgtaatta aaatttggga tgcgacatag 1847161 ccgtgtgcca aaaacagctt tgaataagcc tccattagca atccctggcc gattgaagct 1847221 gatgcttgtt tttctggaag cttctcgggc ctttggataa atccgagctt ccgatatccc 1847281 gccgccactg cgcctgagga aaccaaaatc acttcataac cggcgtcttt gagtttgacg 1847341 acctggtcga ccaacgcttc taattttcga atgctgattt ctccatgaag gcttgttaat 1847401 gaactgcttc caatcttcac aacgactctt ttcatgcttg tatcaggcgt cactttatca 1847461 ctcctgatag cggcgctgca gttttttcga tatcttcgct gatttccttt gaacgcttag 1847521 ccgcatgctt tattgcttga gaaatcgctt ctccgccgcc gctctttttc aaggcttgca 1847581 gccccgctgc tgtcgttccg ttcggtgacg tgatattatc tcttaagatc tcaggatgtt 1847641 ctcctgtttc catgagcatt tttgcggcac ctaaaagtgt ctgtgcgccg atgcttcgag 1847701 ataactgttt atcgaggccc gcttcctcgc ctgtcttttc aatgaattcc attaaataat 1847761 aaaaatacgc gggtccgctg cctgcaattc cggtgaatat atccatttga ttttcttgga 1847821 ttgtatagac ttcgcccatg catccgagca atgcttcggc cagcttcttc aggtcttccg 1847881 acacatattt gccaagggca atagctgttg cagaagcgcc aatcatactg gaagtgttgg 1847941 gcatcactct gacaaccggc tgttcattaa gcaatgattg ttcaataaaa gaggtagtta 1848001 tgccggcaag gaccgacaat attaattgat ggggttgaat acgtgatttt agtgatgaca 1848061 gagcgttttc ggcgtctttt ggcttcattg ccaaaatgag cacatccatg tcttcaatac 1848121 atagttggtt cggcaaggcg cctttaatgc catattgaag ttcaagttca gttaatcgct 1848181 ctgtattgct gcggtttgta acgcagatgt tttgtttcgg gattttgttg gctcgaacga 1848241 tacctgatat cattccttcc gccatagatc ctgctcctat aaaggctact ttcttttgat 1848301 caaagatcgg taacatctcc tttgttcgct tttttgttcg cattttcaca cgtttaaaat 1848361 gttaccacgt gaggaaatga tgtcaagttt gaaggccatt attgatttgt attgtttctt 1848421 ttcgacaaat atgtataatg aaaagcagaa aacacccggt tcacactgct gcgccgggtg 1848481 tttgtttcta ttaaaaatta tctgagagag ctttttcaat cagtttttta cagcgatcca 1848541 gctctacctt cagctgtttt ttatatagct tggcagcttc gtaatcttta aattgataga 1848601 ggacgacttc ctggagctta gccccttctt tttttacttt aatttgtttt agtatcccgt 1848661 catcaagaag ctcatgcaaa gaccggtata cttctgtatg atttggttta aaaccaatct 1848721 ctttaaattc agaccgaagt acttcaagca gctttaaccc atagagtctc tcttgctctg 1848781 tcatcgttat catataaagc ttcaaaaatg cgcgctgttt cactaaaaag cctgttgaac 1848841 tccttttttc ttctttcatc atatgcactc cttcttctgt cactgacaac actatgtact 1848901 aaatattcaa ttttctttta ttgttttcct tctttatatt aaagactgat agtccagtta 1848961 tttcatgttt actgattata ggtgtagcgg aaaaaataaa tttcgactga acatttggta 1849021 catagttttc ttagttctat tatagcctgc atttactgct atcttcaatt taaacgattg 1849081 ccagggttta catatctcat tttaccggta cggatttcat tcaaataaaa aaacctgtcg 1849141 aaagacaggt tttcattttt aaggatttgt tgaccataat cccgctgttt tgatgaaaat 1849201 acgaggatct aatttcagtt gtgccaccat gtactcagca agatcctcag gctgcataac 1849261 tttttcagga ttaccgtctg ttaagttcaa ttcgatagac atatcactag cgacagtgct 1849321 cggcgttaac gcgctgactc tgatattatg ttttctcact tcttgcataa gagactctgt 1849381 taacccgaga acggcaaatt tagaagcgct gtaagcactt gttacagcag ctcctctttg 1849441 gcccgctgta gatgaaatat taatgatgtc tccggctttg cgttcgatca tttccggaag 1849501 caccgcgcga gtgacatggt acacacccat taggttgact tgaataatat tttcccactc 1849561 atcagctgac agatctaaga aaccgccaaa tttgctgatg ccggcattat taatgaggat 1849621 atcgatatca ccgagctgtt ccttcacttg agctacagct tggttaacct gatcggcatc 1849681 ttttacatct gcagcagcaa atgcagcttt tacaccaagc gctttgactt cttcagccac 1849741 tttttctaca ttagcggaag tccggccaat taacccgata ttcacgcctt ctttggcaag 1849801 cgccagagca gtagcgcggc caattcctct gcctccgcct gtgattagtg cagttttatg 1849861 ttgtaaactt tgcaattgaa gcaccctttc tttgtttaca tatgtacgat atcacattat 1849921 aagtacaata catccaatac gcaaatcaaa cgaactgtgt aaatatcatt tcttctgatt 1849981 aaaaaaacgg atacagggta atgacataag aaaaggagtg aacatatgat tatagtttat 1850041 atcagtcttg cagtattagc agtttctatt atcttcttag gagttaccgt gatccaaaac 1850101 aagaaaaaaa tagaccccgc actaaaggag ctttcctctg ttacgcaggc tatgcaaaaa 1850161 caaatcgaag gattaaaaac agaaacagag ctgctgacgc aaaaacaaaa gaagattcag 1850221 caggatgtcc aaataaaaaa atacacgctt cagcagaccg cagctgaagt gaaagaagtt 1850281 ccccaagcag tcaaagaggt gtggcaggca ggacatttta atagcagata aggatgaatg 1850341 agatcccgtt gttacgatca gaatggacaa atgggatctc atttttcgag gaggcttaca 1850401 catgattata aaccgcagct gcttaaaaga gttcgcagaa aaagtacatt ttcttccctc 1850461 ttcacttaca aagtccgatt tacttactga tccatttcgt ctccatcaag aaaacgaact 1850521 tggcatctac tattcacctc ataatgaatt tatcaatcgg gatgcctcgc ttgtgattgc 1850581 cgggatcacg cctggttttt cccagatgaa gacagcgtac gaaacagccg ccgaaagcct 1850641 gctgcaaggc gggactcttg agcaaatggc agtagacaca aaaatagcag cgggtttctc 1850701 cggatcgatg agacataacc ttattaccat gctggattta tgcgggctgc cgcaagcttt 1850761 tggcattcaa agcgccgcaa agctttttgg agaattacgg catatgctcc atacaacttc 1850821 cgttattaaa tatcctgtct ttatccagca aaaaaactat accggataca aaccggctat 1850881 cactcattct cctatcctaa gcacttatgc ttttgggcac ttccctgcag agcttaacca 1850941 tgtgacggga ccagctcttc tcattccgtt aggaaaagcg gccgaaacag tgtgtgaaac 1851001 attgatcaga cagcacagcc tccagaattt gatttgcctt aacggctttc cccatccatc 1851061 aggcgcgaac ggccatcgtt tgaaacaatt cagcaaaaac aaagagcaac tagaaagaca 1851121 aattcgttcc tttgctgcat tggttgattt cgctatagaa aagaggaaat aaaagggata 1851181 tgataaacaa aaacacaaac gtggggagtg gttgaatgtt tcctatatta gaaacggatc 1851241 ggcttatact taggcaaatc acagatcagg atgcggaagc catttttgct tgtttctcaa 1851301 acgatgaggt gacacgctat tatgggcttg aaaacatgga atctatagaa caggccattt 1851361 caatgattca aacgtttgct gccctctatc aagaaaaacg cggtatacgg tggggaattg 1851421 aaagacggga cactaaagaa ctgatcggaa caattggctt tcacgctctg gcccaaaagc 1851481 ataggcgcgc ggaaatcggt tatgaaatca tcccggagca ttggcgaaac ggatttgcat 1851541 cagaagtcat ttcaaaggtc gtatcttacg gattttctgc ccttggactg tcgcgtattg 1851601 gcgcagttgt atttaccgat aatgaagcat caaatcgtct gcttctaaaa atggggtttc 1851661 aaaaagaagg cgttttaaga cagtacatgt atcaaaatgg gactccatat gatacaaatg 1851721 tgtactctat tgtgaaacca agagaatgac ggtattctct tggtctgtgc cacatccctt 1851781 ttcctttaaa aagataaaaa gcgcccctca aacagggcgc tttctaatta agatgcatat 1851841 tgaggagatg tttcctcctt aactgctttt tcctcaggta tatgaataca ttttgtcaag 1851901 accgcacttg caaggtaaag ggccgcaaag atccagacga caccttgcgc gccgacgaga 1851961 ccgatgaaca gccaagcgag tgcagggccg acaaacgctg ataaacctgc agctaaattc 1852021 aatacagaca tggctgcccc tttatctttt cctgccaccg tcggcacaat tgcaccaatc 1852081 ggcacatagc ctgccagcaa accgccccaa ataaagccga tcacgctgac aaccgctaaa 1852141 cttccgccgg agaaaacagg tgcgtagtat aataagacgg tgaaaatgcc gcagccgact 1852201 ccgccgaacc aaataacagt atttttccag ccgaatttat cgccgacaat accgaagata 1852261 aggttaaaca caatgttccc caggaaaatc gttccccaaa tttgcagcca cacattggtt 1852321 gaaattccat gctgggccat gtgcatcggc aaaaagactg gaaaaccata tgtaccaatg 1852381 ctgttgatga ttctgatgat tccgcctgta agcacgcgcg gatttgtaaa tagaatcgta 1852441 acccctttta aaagctcctc ggctgtttct gatctttttc ttttcttctt ttcaaaacgg 1852501 tctttattga taaacaatgc aaagaatgca ccgagacata cccagaaaat agagctccaa 1852561 agcgtattca aataaccgaa cgctttgatc gcgtagcttg agtaccaagc gccgaacaca 1852621 aacatgccga ggcaatatgc aatccaaaac cagccgacag cagtgctcag tttgctttgc 1852681 ggtgttctgt aaatgaccca tgtcaagaaa gaataagcaa aaagcgggta acctaaccct 1852741 tttacgaagt aagtcacata catcactggc aggttcagct gttcaaatcc aaatacgata 1852801 aaagcagctg taccgatcac ataaaacaac agccccataa acatcgttcg ttttgcgcca 1852861 aatgcttcga gacatacacc cgaaaaccag gaagctatgg caagcgcaat tccgtatata 1852921 ctaaaaatgg aagcggactg ctgaacggtg agcccgtttt cgatcaaaaa aggactgagc 1852981 cagccttgtt caaggccatc tcccatcata aacaaaacaa cccctaaaaa tccccaggca 1853041 agccgcttcg gtattcctat tttatccaac atatctgtct cctccttaga tgctattatt 1853101 cattaccgta ttaccttatt aaagttgaaa attaaatgat tcctcaaaac agcagaaatt 1853161 ccgtcttaaa ttaatacttt gctttctgat cctgaaaaaa agcgctgtgt ttgcttccat 1853221 tcctcatata aagccaattc tatctgacag tccttcggtt cgatcacccg gacatttgct 1853281 gacatctcct ccgttaattg aaaggtttca ttgcaaatga ctgcagcacc gacgacagat 1853341 gcctgatgat atccctcttg gacatagacc tttttttgaa gaagatccgc gatatattga 1853401 gtgagcgctt tgctttggaa tccccctccg cacacccaaa cataatcacg ttcaaacgga 1853461 gtaacctctg ttaaaatgtc aaagttccat ttgattgaaa atgcgatctc ttctagcgct 1853521 gcacgtacaa aatgtgccct ctttaaatgt gctgacagcg gggcatcaaa aagaaaaccg 1853581 cctctcgtta acgcattctt ttcagccgat aaataagagc cgagagccgc tacacatgca 1853641 tggtcttctt ttgcaagtgc agaaatctcc tcctccatta cttcgtacgt ttcattcgga 1853701 taaaaaatct gttttaattt ttgataattc aagccggtaa ttcccggatt cgtttccaca 1853761 agccaatgcc cttgatccgt atgacagttc aaccaggctt tatgttttgt gtcgccatga 1853821 tcctcagtaa ttttggttat tggcgttgtt gtccctgata caatgacaat gtcctcaagt 1853881 ccagctccgg tgcttttgac agccagctgt gtatccccgc cccctgctat aaccttagca 1853941 tttattgaaa ggcctaattc ggatgcatat tcatttgcta tcgttccaat tgctgttccc 1854001 gctcttacaa gaggcggaag gatagatgga gaaaagccga aaatgtcgca catctcttct 1854061 gaccaagtgt tttgcttcac atcaaatagc agggtttctg ttgcctgtga tggttcatat 1854121 gttaatattc cgctcagttg gtacgtcacc caatcactga tgcttgtaaa gcttgcagtc 1854181 ttttcccata aagagggctg gcgctgtttt aatccataaa gcttgagcgc agaaaaaagt 1854241 gcagttggca ggcggcctgt gctgctgtat atctcttccc aatcgggaat gcccgcctcc 1854301 cactctcggc cgcgattatc gatgttcggc agcccgagaa aaggattgcc gttttgatca 1854361 atcaaaacaa tcccctgtct ttggctcgtc gatgtcaaac caatgatgtc aatatcacac 1854421 gaacgggata gcgcacgttt tgccaaattc atcacctgct tccacagcac ctgaggagaa 1854481 aaataacggc tgtccgggta aagcgtctct gtggaatact cgatgtcctc ccgttcaact 1854541 gttagaacac tgccagttac actcacgacc gctaccctcg cattgcctgt gccaatatca 1854601 aaaacgagat agcctttttg ttttttcatt ctgttagcct cctttcttat ccccctgttt 1854661 tcagtgcgtc cttgttatac attgtctgaa tattaagagt tttttcaccc ttccactttt 1854721 tgagggcttt attcagtatc gtcacgtgat gatcctccac ttcaaatgtt gctccagcga 1854781 gatgcggtgt tgccagaaca ttaggcaatg aaatcaattc ataatctgat tcctctggag 1854841 gttcatgata aaaaacgtct agtatcgcac cgctgatttt atgttctttt aatacaaata 1854901 aaagatcttc acggtttaca acaactgctc ttgaagtatt aacgaaaatc gcactctctt 1854961 tcatcagatc aaaatattgc cgatctatca gtccgagtgt ttcctcagtg cgaggcagat 1855021 ggacagaaac gatatcgctg tctgaaaaca ccgttttaag agatgctttt tcatacaacg 1855081 gatgatcgtc ttgaatgtat ggatcgtaat attttatctt acagtcaaac gcagtcagca 1855141 gttttgcaat cctttgcccg actgcgccga acccaatcat gccaaccgtt tttcctgtta 1855201 gctcatttcc tttaaatttg acataagcct gcaggtaatc actgtcccac tctccatcct 1855261 tcagccactg attcgaggcg ctggtatggc gcagaaagga aatcacattt ccaataaaca 1855321 tttcggcaac ggcttgtgca ttccgccctg gtgtataaaa aacaggtatg cccctttttg 1855381 aggcagctgc cacatccaca tttgagggca ttcccctgca aacaccgaca aatgaaagtt 1855441 cgggaacaga agcaaatacg ctgtctgtta cctgatcaag ttcagtaatc aagcctgtcg 1855501 catttgttgc ttttagcagc tgaatgagtt catcctcccg atatgcccta ccttgttcct 1855561 tccaagattg ataagcaact gagccaaaca agttttcaag ctcttttcgt ccttcttcgt 1855621 tgtacggtgc tgtaaccaaa accgtcatgc tgcaaaacat ccttttcatc gtatttttca 1855681 taaaaaaaat ctctttccga agatggaaag agattcatat ataggcgcgc tctgttacag 1855741 gcagacgccg gtataaacct tgctttccta tctttcaagc tagcgcttgc tggaattggc 1855801 acaataatgt tgccgaggtt tcatagggcc agtccctcca cctctctgga tagaaaatat 1855861 tgagtatgta attttcagaa tgaagaatac gtttatcata aagaagactc agattgatgt 1855921 caatctcttt ttttcagaat tgacgttatc atcggaaatg ttataattct tacaaaatat 1855981 ctaactagag agaggaactg ggccatgaga tcttttgcca cacaacaaaa cggcattttc 1856041 aaatccgttt gctcgctgga ctgcccggat cagtgcggat tgttaataca taaaaaagac 1856101 gggaaaatcg taaaagtgca aggagaccct gatcatcctg tcacagctgg aaacatatgc 1856161 aacaaagtcc ggaatatgac ggagcgcatc tatgatgaaa agcggctgac tacaccgctc 1856221 aaacgaacag gtgcgaaagg ccaagcgata tttgaaccga tttcctggaa agaggcaatc 1856281 gatacgatca cctcccgctg gaaacagctg attgatgaag agggagctga aagcatactt 1856341 ccttacagct tttacggaaa tatggggaaa ttgacagctg aaggaatgga ccgccgcttt 1856401 ttttaccgca tggggtcaag ccagcttgaa cggacgattt gcagcaaagc gggatctgaa 1856461 ggctataaat atacaatggg cataagcgcg ggaatcgatc ctgaggaaac cgttcataca 1856521 aaactattta ttttttgggg aatcaacgcg gtcagcacaa atatgcacca aattacgatc 1856581 gcccaaaaag cgcgaaaaaa aggtgccaaa attgtcgtga tcgatgtgca taaaaatcaa 1856641 acaggacgtc ttgcagattg gtttatccca ataaaaccgg gaaccgacag tgcacttgct 1856701 cttggcatca tgcacatttt atttaaagaa aaccttcatg atgaagcatt tctgtccgag 1856761 tacacggttg gctatgaaga gctccgtgaa cacgtgaaac aatatgatcc tgaaaaggta 1856821 tcgacgatca ccggtgtcag taccgaagat atttaccgac tggcaaaaat gtacggggaa 1856881 acctcccctt cttttatcag aatcggaaac ggaccccagc atcacgataa cggggggatg 1856941 attgtaagga cgattgcctg tcttccggcg atcaccggcc aatggctgca cacagggggc 1857001 ggcgcaatta agcataacag cggaatttta gaatataaca caaatgcctt gcagcggccc 1857061 gacttattga aagggcgcac cccgaggtcg tttaatatga atcagcttgg cagggtgctt 1857121 ttggaaacag acccgccgat tcgctctcta tttatttacg gaacgaaccc tgccgtcgtc 1857181 gcgcccgaag caaacaaagt cagacagggc ttgctgcggg aagacttgtt tactgtggtt 1857241 catgatttgt ttttaacgga aacggctgca tatgcggaca ttgtactgcc tgcaacatcc 1857301 gcttttgaaa atactgattt ttacacctcc tactggcacc attacattca gcttcagcag 1857361 ccggtgattg agagatatgg ggaaagcaag tctaacactg aggttttccg attactggct 1857421 gaagccatgg gattcacaga ccaggagctt aaagattcag atgaagtatt aatccgccag 1857481 gcgcttgacc atccagataa tccgcatttg gcagagattg attacgattc acttactaag 1857541 cattcattta tgaaagcgaa acgtgaaaag ccgctgtttc cgggcgaact tccaacgcca 1857601 agcggaaaaa tagaattata ttcagaaaaa atgaaacaag acggcttccc tgctttaccg 1857661 acatatacac ctcttgtaac cgataatgaa catccgttta tgtatgttcc ggggccaaac 1857721 cataatttct taaactcaac attttccaat aatgaaaaac acatcaagct tgaaaagacg 1857781 ccaaagctct ttatcaacac aaaagatgct gaaaaacacg gaatcgttga tggggcacct 1857841 gtacgaattt ggaacagccg gggagaatgc gagctgaccg ctgcagttgg agaacaagtg 1857901 ctgccaggtg tcgttgtcag ccaaggatta tgggcggatg aacaaggaaa aaaacagctt 1857961 gtaaacgcgc taaccccaga tcgcttgtcc gatatgggcg gcggcgccac ctttttttca 1858021 ggccgtgtac agattgaaaa ggtttgaaaa ataatgaaac ccggagtatg ccaagcccgt 1858081 ataacataac atcgacataa tggaggcata cacatggacg tttttttagg aattggtatt 1858141 gctttggctg gatattttat cggtgaaggc ttaaagcaga ggaaccaaac caaaggtaat 1858201 gaacaaaatg atatcttcct aataaaagaa cgggatattt acttttacat tggacttttt 1858261 ttaggaataa caacgactga agcaaaacag ttagctggag acatggcaga cctgccttac 1858321 atcgaaataa acggaaaaaa atatgtccag aaacatatgt taaaagattg gacattcaca 1858381 ttagttgaaa aacatcaggg tgaataaaac aaatctgagg agagcgagat tcattgtcac 1858441 gctctcctct gtttagctgt atggatcctg ccaccaaaac tttgtgctat aagcgctgat 1858501 aaaacgataa accaccatct atgttctttc ctcaaacaac tcaagatgcc cgttccacaa 1858561 caatagtttt tatattcctt tgatgacgtg atgttcttga tgaacgtatg tatcgtaaaa 1858621 cacttagaaa acctattcgg tttgaatgtg tgctctcatt atgcccccat actgcgcctt 1858681 tatccgcgga ggattttttt aaaaaaatat gaaacctaaa gcttttagat cctgaatttt 1858741 tattgaacct ccatatttct ccgattggta aaaattagcc tatacaccgg aagctgtacg 1858801 tttataaagg atcagagaat cccataacca gtaaatcact gcagccgcaa tacttaacat 1858861 ataataaaag tacgattgca atgtccatgc tattgacgca ggttcattga taacaaaaaa 1858921 caggaaagct gcgataaaag caaccacact gtaaatcaat aggtacatga cattgaaagt 1858981 tctcgctttt ttctgcaact tcatttggag cggaacagca aaaaggccat acaccacaaa 1859041 accgtataat aaagcaattg ctgccgtaaa caatgcaatt atcatatcgc catacataac 1859101 gaaagaataa aaccctaata acaaaccaaa tgtaaggctg gatagcccta atgtcattaa 1859161 ataatatgat gcgatttttt tcattttttc accccccttg tttgatttat tcacagtgct 1859221 gttagtataa attcacaacc tttgtatttc ttttatcgag atgtcttccc taacgtgcta 1859281 tacgcaatgc gctaataaaa ggtttcaaaa atgacgttct tttattagat aatacgctgg 1859341 ctgaaaacgc ctctcctgat tggccaaagc gcgaatgaaa aaagtgcatg aatacctgcc 1859401 caacagacag aataagaaga gttgatattt caacactttt cgtaaagggg tgaaaccaat 1859461 gagtaagaaa ggtattcaaa attcaagtat tgaacaaata agaaatgacc atgagactga 1859521 aacagctttt aaagcagatg atcctaaaaa acacggttcc gatcctaaaa gaacgaaata 1859581 agttcttacc cccactaaaa tatcaataat ctggaggaag taaagtgact caaaaaaacg 1859641 gtgcagacag acctgatgat tataaaagat tttcttcatt agacaaggaa tatgattttc 1859701 agcaatctat acgcagcaat actgagacag aaagtgtaaa cactgaaaca caaactcata 1859761 acaaagaaaa caaaaatgac acaacagatg ttgccgggaa atactttgag ccctcagatt 1859821 ataaaggaag cacgcaatta gaaaaaggat tggctgaaac tcatgaacag gtcagcgatg 1859881 actattttga agggacaatc gatcaaaatt tggactagcc atacaaacgg aactaactta 1859941 aaagaagtca gttaactctg tttttagaaa caaccacagt aaaagtagcc aacccccacc 1860001 gaataagatg ggggttgcac gtaagtagcc tgtttaatat ttaaaacgat taatgacggt 1860061 ttgaagttct tctgccaact gagatagaga ttctgcggca taggagattt cccccattga 1860121 atgaagctgt tcctgtgatg aatttgcaac cgcttctgta tttgctgacg tttcttttgt 1860181 accagcagcc aatgtatgaa ctgtgtgctg aatcacttca acgcctgaag taagctgttg 1860241 agttgctgct gcaacttctt gtatttgaga agtgacctgt tccaccaggt tcagtatttc 1860301 attgaaattt cctgttgtct cttgagaaag aacaatacct gagctcacat tttcttgaac 1860361 aactttaata ttatttaccg tttctatcga ttcgttttgg atggtcgcta ccaccgattg 1860421 gatgtggttt gcagatttat ttgtttcatc cgccaacttc cgaacttctt ctgccaccac 1860481 agcaaatcct tttccttgct ctccggctct ggccgcctcg atcgctgcat ttagtgccaa 1860541 caaatttgtc tgctctgaaa tcgtcgtgat aagcgaagag atatcgctga tttctgctgt 1860601 gctcgctacc aatgtttgca atccattgcc ggctgaatct acagatttat caatgaattt 1860661 catctggtct aacatcttgt tgacggactt agagcctatt tcagccttgt ctctcatcga 1860721 agaagaaaga tccgctatgt tccctgtatt tgaagcgact gatgatatac tgtctaataa 1860781 ttcagtgatg gattctgcgc tcttttctgt cattgagctt tgcttcacat tgctgtcggc 1860841 agccatctgc atggctcgtg aaatatgttc agatgttgat ttcgattctt ccgcgcttgc 1860901 cgataattct tcagaggaag cggcgacttg ttcagatgag ctgctgatct gcttcacaat 1860961 ttgagttaat gaatgagtaa aagaattaaa agattgggca agctggccaa attcatcttt 1861021 atttttcaca atgacttttt tggttaaatc agcctcgccg tgtgcaattt cctccagctg 1861081 cttatttatg cttcttagtg gcaccataat ggactttaac agcattatgc ttagaacaat 1861141 gcctaatatt actgatatcc ctgtgacaat gataatgagc gattgactca ttttcccatt 1861201 gccctgtatt tcatccttta gatcctctac ctcttgatcc aggcgatcag acagcttatt 1861261 gacagccgga gctacgcctt cttttcttat tgttctttct tctccaaaat ggatggtttc 1861321 tgctttttta ggatttgaag agtaggctgt tactacttgc tgattcaaag ctctatactg 1861381 agtaaaactt gtcttaatgt cttcaatatt ggattgatac ttctcttcat caatcaagtc 1861441 attaacccgg tcaaggctct ttaagacatc gtctgctttt cccttcatac cctcgtcgta 1861501 ttctttgtct ctggtaatca agaagcctct ttcatcattt gataacccgg tcaattcata 1861561 ttggatgtgt tttatctctt tttggaattc cattttgtct ttaagttctt cattcttttt 1861621 cacagtagaa gaaatcataa atactgagga gcctccaatt ccaataattg aaacaactaa 1861681 tattgatata atccccagca attttgtttt cactttcatg tgtcgttttc cctttccgca 1861741 caatgtaatg gctgaaataa aatatgttca agcgcgtttg aatccaattc gcttacgctc 1861801 atgtccataa tatcgacacg tgttatcaag ttttatagtg atattcttat atgaataagc 1861861 aaattcttta cgtctctgaa cttacagaaa aaccttaagt aaaatttgca gtcttttgcg 1861921 gtatgtaagt cactcttatt cgtttttcta aaaaaggctt ttcccacctc aaattggctg 1861981 aaccggctgt tttctcgaaa atataataca atacgcagca taatatgaag gagcgaaact 1862041 taaatgggga tcatcaatgg taaagaattc attgaccgat tgaataaact agaaaacgaa 1862101 atatggtatg atggcgaaaa aataaagggt aacatttctg agcatcctgc atttaaagga 1862161 ataatcaaaa caaaaagctc actttatgaa ttgcaaacaa aggatgagtt aatacatgaa 1862221 atgacttatt gccttcctgg agatcataat cgaatcggcc tttcctatct ccagcctaaa 1862281 acaaaaaatg atttgaaaaa aagaaggacc atgattgaac attgggctag acatactcat 1862341 ggaatgatgg ggagaagtcc ggattacatg aatacggtta tgatgagctt tgcttcgtca 1862401 gcggagcttc taaaagataa agagaattgc tttcctgaac atatactaga tatgtatgaa 1862461 caagctgcta agcatgacct ttcctttacc catacattca ttactccgca agtgaaccgg 1862521 tcacagtcct attttgggct aagtgaaaaa ccgatatctg ctaaagtcat tgatagaacc 1862581 gaaaaaggtt taatgattca tggcgcacga ctgcttgcca cacaaggcgg gttgaccgat 1862641 gaaatcttgg ttttttcagc gcctaaattt ttctttgaaa cagatgaagc ttatgctttt 1862701 tcaatccctt ctaatacaaa aggcgtaaaa ttcatcacaa gagaatcatt tgtattaagc 1862761 gactcttcct ttaatcatcc cttaagctca aggtatgaag aaatggattc aattgtggtt 1862821 tttgatcatg tgttagtgcc gtggaatcgt gtgttttttt acgataatgt ggaagcagct 1862881 aaagatttta tgacaaaaag ctcttttcat gcctttacct ttcaccaggt tgtcattagg 1862941 caaatgataa aaattgaatt tctattaggt gttgcacagc ttcttgtcga caccattaat 1863001 gtttccgaat atcagcacat ccaagaaaag ctctcagaaa tcattgtggg attggaaaca 1863061 atcaaagccc tcattgacaa atcggaaaat gatgctcagt tagatgaatt cggctatatg 1863121 cgcccctgtt taattcctct tcaagtcatc agtacgatca ttcctaagct atatcctcga 1863181 tttactgaaa tcatacaatt aattggagct agcggaatgg tgacactgcc taccgaaaat 1863241 gcatttgact cagagatacg ggaagatctt gaccaatatc ttcaagcaac caatacaaat 1863301 gctgaagaac gtgtgaaaat tttccgtttg gcatgggatt taacaatgag ttcattcgga 1863361 actagacaaa ctcactacga aagatatttt ttcggagatc ctattcggat ttcaagcagg 1863421 ctgtatacca gttatccaaa gcaggagcag ttgaacatga ttaaaacatt tttacatgca 1863481 gatacagaac attgaaaaaa cagcgggaaa agatccgctg tttcgtattt tttattcagg 1863541 aaactgaaca tggcccggta ctgtataggc tttggacgtt ccgctttcag gcagctttgg 1863601 aatggtgtct ttcacaactt ttccgcggat gtcagtcatt ctgactttga gagagccagt 1863661 acctaaattc gtactcacaa aatggttata gtccattttc tccatgttga tccacttacc 1863721 atccttttca tattccattt tcataacagg atacttgtga tttctgactt ggattgctgc 1863781 ccaccacctg ctgctgcctt ctttgatccg gtacgtgaaa ttgccggtga ttggggcttt 1863841 gacaacacgc catttaatat tgatttttcc gtctttcata ttgccgattt tacggaaggc 1863901 attaggtgac agatcaagag ctccccgagc gccttcggga taaagatcag taacatatac 1863961 ggttgttttc ccttttggcc cttcaacttc caaataagag ccggcaagtg ccgcttttac 1864021 tcctccgtaa ttgagatccg ccggatttat tgcagtaatc tccatatcgg aaggaatggg 1864081 atccagcagg aaagctcctc ctgaatagcc tgaccctgta tacgttgcat aaccttcatg 1864141 caggtcgtca tatgctgccg aagcttgcgg ggaaaaacag aagatcgtca acaaaaccat 1864201 accaacaaat gcactcatga tctttttcat atttggtcct cctcaaacca gacttcaaat 1864261 gagaatcatt atcattataa gactcaatcc atctggtttg aaagaggaaa tagattcata 1864321 gttgatttta aggcaaattc actatcattc atatatcaaa tgtaggtact tatgaaaaag 1864381 ccaatacaaa tgaacgaatg tgcacttcag ccgaatgtct tatttttccc tctcaaaatt 1864441 cgcatttcaa taacgaaatg aaacaggctg ttggcctgat aacagctata caggaaaagc 1864501 tatttttccc cgctcagttt caacttagct gtcatcatga tgccaaagat cagcacaatc 1864561 ggaacccaaa taatgaagtg ataaaaatca ggctcagcca gagcaacaat aatagcccct 1864621 acacaataca aaataatagc cagtgctctt aacacagtat ctcttaagaa agtcttcttt 1864681 tgcttcttaa aaaacaaacg gccggatata tcctctaaaa gagaagccaa agtgccggtc 1864741 aacacagttg aagaaatacc tgcaatcccc agtttttttg ctgctgtagt ttgaatcccc 1864801 atagaaatgc tcatgagtat aattagaatg tgcacaggaa caaatgcccg gtaaaaagaa 1864861 agacaagcaa agacaaacaa aatgaatgct tcaagtgcga gggcttttgt cacagcagaa 1864921 ggccaaaggg tattttccgc ctttccgacc atcaatgtag caatgatcac gccgcatata 1864981 aatccgatta gcgcagtcaa ggaattaaaa acagtgacct gaatggattt gccgatagct 1865041 aaccccaata atacaatgtt tccagtcata ttagctgtga acacatgtcc caggcttaaa 1865101 tacccgatta catccacgat tccagctgtt aaacataaaa gtgatagcaa ggtgtttcga 1865161 taagctgctg cagtcaacgg tgtatcaatc ctttcttcta tttcaattgt tagtatgtct 1865221 tttggcgcaa tctctatttt ttaagtaacc caacattaat taggaagata gaacctatta 1865281 ttcctttcca ttaactgtaa taataatccc cgcaaggaaa tgattaaaat tgaaaggaag 1865341 catattgtga tgaaacgact ttgtttatgg ttcaccgtct ttagcttgtt tttggttctc 1865401 ttgcctggaa aagcattagg tgcagtcgat tttccgaata cctcaacaaa tggcctttta 1865461 ggttttgccg gaaatgccaa aaatgaaaaa ggcatctcta aaacgggcac aacgggtgga 1865521 aaaaacgggc agattgttta cattcaaagc gtaaatgatt taaaaaccca tctaggagga 1865581 tccactccga aaattttagt gcttcaaaat gatctttccg catctgcgaa aacaacagtt 1865641 accattggct caaataaaac actcgtgggc tcttacgcga aaaaaacgct gaaaaatatt 1865701 tatttaacaa cttcatcagc ttttggaaat gtcatttttc aaaatttaac gtttgaacac 1865761 agtccgcaga ttaacggaaa taatgatatc cagctttatt tagattccgg tatgaactat 1865821 tggattgatc acgtcacatt ctcaggtcat agctataatg caagcggaag cgatttggac 1865881 aaactcgtgt atatcggaaa atccgcagat tatatcacga tcagcaactc aaaatttgcg 1865941 aatcataaat acggtttgat tttaggatac ccggatgatt ctcagcatca atatgacggc 1866001 tacccccaca tgacaatcgc caataattat tttgagaact tgtatgttag aggcccaggt 1866061 ctgatgagat acggttactt tcatgttaaa aacaattaca gcaataattt taaccaggcg 1866121 attacaattg ctacaaaagc aaaaatatat tccgaatata attactttgg gaaaggcagt 1866181 gaaaaaggcg gcatccttga cgacaagggc actggttatt tcaaagacat aggcagctat 1866241 ccatcactca acaagcaaac ctctccgctg acttcttgga atcctgggtc aaactatagc 1866301 tatcgtgtcc aaacgccgga atatacaaaa gaatttgtca cgaaatatgc cggatcacaa 1866361 agtacaactc tggtatttgg ctactgatat aaaagaggcc ctgcgttaaa aacgctgtgc 1866421 ctctttttat actataggct atttttaagc gatccttgta attccatcaa gatccagcgt 1866481 cggtcaaact aaaaagcata tgttcttttc cacaataact tcttaactgg ctttcttatt 1866541 ataccagttt atcgcaagtg aaaagaaatc attgttctga acctgtatta aatgaacgat 1866601 cgtcccacaa actacttaaa aacccctaaa aaggatgatg gatatgtgcg gcaggtttac 1866661 tttgtactct gcatttgatg atattattga ccagtttgac atcgatcaat tttttcctaa 1866721 aggtgaatac cagccaagct ataatgtcgc accatcacaa aacatccttg caatcatcaa 1866781 tgatggatca aataatcgct taggcaagct tagatgggga cttattccac cttgggcaaa 1866841 agatgaaaag atcggttata aaatgatcaa tgctcgagcc gaaacaatta ccgagaaacc 1866901 ggcctttcga agaccgcttg tcagcaaacg ctgcatcata ccagcagaca gtttttatga 1866961 atggaaacgg cttgattcca aaaccaaaat cccaatgcgg atcaaattga aatcatctgc 1867021 tctttttgcg tttgctggct tatatgaaaa gtggagcaca catcaaggat accctcttta 1867081 tacctgcacc atcataacaa ctgagcctaa tgagttcatg aaagatatac acgaccgaat 1867141 gccggttata ttggcccatg atcatgaaaa ggagtggctt aaccccaaaa atacaagccc 1867201 tgattatctg caaagtttgc tgctgcctta tgatgctgat gacatggaag cataccaggt 1867261 ttcatcatta gtaaattcac ccaaaaataa ttcagctgag cttcttgatg cagaaaatca 1867321 tatgtagtga ttgaaaaaat tctctagcaa gaacttgtca aatagctttg ttccttaggt 1867381 gccaatccct ctagtaatta tgaatattta gtacatagat caattagtta tctttagcat 1867441 cagtttgaaa taattttatt atgtaaactt aaataagcaa tgttattcct ttcatataaa 1867501 atagtttaca tttttataaa atcgcttcac ttttctattt tgtcagcaaa aaaactgaac 1867561 cacattaaac ttatgaaacc tgccgcacct gtggattgca aatatgatat aagcccatag 1867621 aggtaaatcc atacactttc cctcctaaga attaaatgaa atttctttca tcttacatga 1867681 aggtcttctt tcttttgttt atccagtgta atacttaata atatgttgat gaatgcagct 1867741 ggaaaatata taaatcccac tccaagaatg cctagtatcg tacttaaact tactatgtaa 1867801 ttctttgtca tcgtttgact gtcaatcaat attagaagtg aaatcaatcc agctaaaaca 1867861 cctataaacc aagcatcgcc aacagcataa gaatcatcca gcatccctaa ccatcgcccc 1867921 aatatagagc tcccaatggc agtcaaactg gataaaaata tgagtgcttt catttcttct 1867981 cctcctttaa agccaatcaa actggtagaa atcggccatt gaatccccat tatcgaatgg 1868041 ttaccatttc atttccacat taacatttta aagctcatta caatacgatt caagcagaaa 1868101 aaccctacat aacgtatata tagggattta ataaaacaca ggccaaaatt cagctctatc 1868161 tactttaaaa agatatgaag ggcagctgtg tgatctgtta cgtctttacg taccgggata 1868221 tttcacaaca ggcactttct tcttgcgcag agaatcaagc atgactgatc cagcattcaa 1868281 gttgctttgt actaattctt taggcgtcaa tgccatccac tgattgagtg acacatctgc 1868341 atagcggtta cttttgaaca tttctaaaaa ccataatgtt tctgtaccag tgttttgtat 1868401 atagtgtccg gcattagaag gcacgtatcc aacgtcgcct gctctataat caaatgtgcg 1868461 ggcagtccca tttccgataa ataccgtcat tcgtccctgt cctgttagat aatattgcca 1868521 ctcatcgcta ttgggatgcc aatgaagctc tctcatcgcg ccaggctcaa tctgaacaag 1868581 tgcagcggct atcgtttttg aaattgggaa gttagaagaa tccacaattc gtacactccc 1868641 ccctggcatt tgaattgggg gttgatttaa cagctcgtgt ttaaaggtca tggggacttt 1868701 tccatatggt gactgaatgt cttcactggc gactgatccc ggcacattcc cttggtagat 1868761 atagacttgc tcagacggaa gagagttgaa agcattctcc gggacaccga aatttgcaga 1868821 cagaacatct tttggtgtgt gtgcaagcca atctgaaatg gttaacgttg aaaactcaga 1868881 aaagttccca tcatcgaaaa cgagcagaaa ctcgcagtgt tccaatccct gtatggaatg 1868941 cggaattcct gccgggaagt accaaaggtc gccgggacca acatcagcaa tgaaatttcg 1869001 tccgtcttgg tcaacagcgg tgatacgtgc ccgtcccaaa agcatataag cccactccgc 1869061 ttgcttatgc caatgaagct cgcggacgcc tcccgcagtt aagctcatgt ttacacctgc 1869121 aatcgcagtc gaaatcggaa gctgtcttac ggtgatttct cttgaccagc cgccgtgatc 1869181 taatttcatg ggagcgtctg agaatgaaaa tctcaagtta ggaatcatac cctcatctgt 1869241 aacaggcgga acaaatatat tcggattttg aatatcccgt attatatttc gcgggcctgt 1869301 atcaatagct ccagctccat cacttcgaat aggctgcggc acgtttctgt cttcatgatt 1869361 gattggttgt tgttccaaca gcatgcacct cgttttagaa atgaacaaga ttttatttca 1869421 gcctatgcag aatcttagat tgctgtgcct aggaatccgc aaataaaaaa gtgaccacca 1869481 atgtgatcac aaatacatca aataaactat tttttatacc atggcttctt atgtaatttg 1869541 attgcttctg tctgtttttt ctggcctgtc ctccactcca cttttactaa tacatcatga 1869601 cctatcactt catcttcagg catataatca aaggtggaaa tatggtcctc catgcgtccc 1869661 ccacccggca tttcatcacc tgtgtactcc gataagtcgt actcatctac gttatcatct 1869721 tgatactttt cgccatctac atacagagta attctttcaa caacagtcca cttttcttcc 1869781 ttcttactcc cctgccaata tagatttaga aaataattgg gtccaattga agttttgtct 1869841 gatttttcaa ggttagacat ccacagtccg cttttcccgc tgccctcata tttcactttg 1869901 ttccctgaca ccattacaaa taatgtgatg atgcagatga tcaagaatcc agcaatgatc 1869961 aatagccatt tcttaatatt gttctttttt ctcatgtttt tcctcacttt cctaactttt 1870021 tagtaggaaa atacgatcaa aatgttaccg aaaagaaaat aagaaagggc taatgatcta 1870081 acagatgact gtctaaactt ttgacttaaa ttaaagtgct ttctaaagac aagattaaaa 1870141 cgtataacag ctcttaaatg cattttttgt ttcattgagt caagaacctt aaaatggctt 1870201 tttattatta aaaatcaagc tagtgtatta agtaactttt caaatttatt tatactcatg 1870261 atctcgtgag tcacaaatct cccatcaaaa aaaacgctaa aagttgtcca aatagctggt 1870321 gacttttgtg cctcttcttt cgatgataac tgaattgact gaaattgaac ccctttcttt 1870381 tcagtcaatt cccgcaaatc atttatcatg cccactgcaa acggacactg agctgtatag 1870441 tatatcgtaa tccccttttc attgatagaa tcacttttca cctggctctt aaatgcagga 1870501 gaatctgcaa ggccattcca agtcaaagcc attaattgaa aataaggggc agcttcatct 1870561 tgtagagtaa accccatatg ctcaaagaaa tgcttatcac ttaaataggg cagttttttc 1870621 ttgcctgcga tatggataat gccatccatg ccgcacgctt tcgcatctgc tatacatttg 1870681 tccaacaatc gtttcgcatg accgttattt ttatatctgc cagacaccca cagacaatta 1870741 atgtacataa aattaggcgc attgataggc acccatgcct cattcgcagg taggtattca 1870801 ataaagactt ttgcccgttc atgtaagcga tagaacacca atccttcatc cattcgagct 1870861 ttgagccatc tcttcttttc attaactgca tgctcatatt gtttcgtgct taatgcacag 1870921 caaatatgat tgtcttcaat attgtccttt gtgatttcaa tgtagcacat ctcctctttc 1870981 ccccctttaa cataattaca tggaattcaa cttcacactt tacatgccta atagaataaa 1871041 tacccgttcc aacttaaata ctttttcttt tccattttgc caattaactg taaaaccctt 1871101 cttttattca gatattatct tgattcctat atcacccatt tcaaatccaa agtgtgttca 1871161 tctttgagga ttagatgcac tgcttatgct ataaatacag tacacgaagt tttttatttg 1871221 aagtaatatt tgttacggga cagcaatagt aaataagtga taaaagggga attaaacttg 1871281 gtggaaaaat gttattcttg tttaatttgc ggatacaaag gattaattca aaatcctttg 1871341 tataaaggcg agtatcaaaa aacgtttgac atttgtccat gttgcggttt tgaatttggc 1871401 tacagtgagg atcatgatgt gaggttaggt tttattgtaa ctcctgatca tttaattgag 1871461 gctgcatttc aattgtatcg caaacaatgg cttgagagcg ggatggtaat tgctcatccg 1871521 gaagatattc cagaagaatt gaaaaatggc aattgcttaa aatttgaagt tttgttgaaa 1871581 caattgaaaa aactaaatct tgacatagaa aattttgaaa ttagcggttt ttaatgatga 1871641 aacaggttgc acttgtttag gtttcactgt cattatcagt aaaatgttaa gttgaaatgc 1871701 gcaatcagtc acaaagtctc tattcgtatt caataaagac tttgtgatca tcgacaaaca 1871761 tttcactccc atcggataaa gtatccaaaa ggcctcctct ggttcttctc tatagtcatt 1871821 aatcacagtc actttgacat ttgactcagc tatgattggt tttccaacaa tttttcgttt 1871881 tttcctcagg caaagtaaga gatcgaatca tcaaagccat tccatcttta ctgtctaatt 1871941 aacgccatct tcagtgaatt taaaggtctg ttttaaattg cgtccttctt gccccttctg 1872001 tgtccaaatt ataacaacct ctaattcaga ggccttatct gccagcataa aatgattgaa 1872061 cttcagcggt gagccatcat ttaaactttc agctaacatt ttagaatctt cttttggttt 1872121 gacacaattt tcatcgggac atccaaaaag cgaaaacctt gtgattgaat tagggtcatt 1872181 tctatacaat tgcacatcca ctgtagctgc tttttcccct atatttttga cttccaagga 1872241 atatacttga tattctcctt tatgaggtct cgtaaattcc tttacatttt ttgcttcact 1872301 tacttttact gaccactggt ctgttttttg tgtaataggc aacaccgtaa aagtcagggc 1872361 atgcgctttt gattggcaaa acgtaaatcc aactgctgta aaaacaatta cagaaaataa 1872421 tacccttttc acttcattta tccctccttc ctttcactgg ccgctcctta aagaattgat 1872481 tttgagcaat ctacaagctc tcttaaccaa aaccttacct gaggttttgt ctttactgct 1872541 ctgcatttat ttctttcggt atccgagaag gagctttggg gatttttctc aatctgctgt 1872601 taatcacatc agaagagtat agcgtaataa tcatacttcc cccatacctt tttgcccgaa 1872661 ttaagattgg ttggttatat tggttttgaa agcgaaagtc aggacctccc cagcttaccg 1872721 tcgcatcccg tccgggcggt acatatggta cacttctagt atgagaatag cgctgaacga 1872781 tctgcagtcc tgcacgatct actgcattaa atagagttga ggacacctga caaattcctc 1872841 ctcctacacc ttcagacaac tcccctttta caataatggg tgcactttta tatcctttgt 1872901 tccgagttct cattcccaca acttggttaa acgaaaacgt ctcattaggg aaaacaacgt 1872961 gattgtcgat tgcttttgca gaaagagaaa tattgtgtga acggctttta ttgcttgagt 1873021 taaaatacgt cacgtactga ccaagctgct gcgtactgat gtgagctagc agctcgctgt 1873081 caactttcgg ataaatgttc atttccggca cttctatctt ggagggacct tgcccataaa 1873141 aatacgcata aaacttttcc ataaacgcct gttgatacag tttgtagcca accctgcccg 1873201 ggacgatgct tccatgatcg ttaaggacag catttatcgg ctcacggtac actttctgat 1873261 caagctgttt gatgaattta ctgtattttt catagtcaac cattggagtg ccgggaagag 1873321 gcattgtaaa gtcttcacgg ttaacagtgg caatcgtccg tccttgctgt gtgaccgtta 1873381 aactgtcctg cggctcactc ggctgagcca ataaaaaaag accagtgatc aaaatttgta 1873441 tcataagtcg gtttacctcc caatcattag tatgaacagc cgcttatcct ttgatgtatt 1873501 tcttcccatc gtttgtttga atctttagac gttgataaaa accttcataa aagagcttag 1873561 ctttatgttc acaccgatcc ctgagctcac tgaggcacac ggttcattca gtcggcaagt 1873621 ttgaagtagt tcagcatctc ccagtgatga gggatgcttt tttgtcttgt caaaaatgaa 1873681 aagggtctcc tataacaaca aaaaatcaat ccatttcaat atttttttat tgagaaacga 1873741 taaatttttt gttacattca attagacaac aaataaatga ggtgcttgtt atgaatcgaa 1873801 tgtcgacaat ttttttaaag atagctttgg ttcttattgg aattccaatt cttgctttat 1873861 gcattttttt agtgcctaag gtagccaact attcagcaga attatttcca aatatcgctt 1873921 atataaaata tctcgttttc atctatttgt atgtaacggc gatacctttt tactttgctc 1873981 tttatcaagc gttcaaactt ttaagctata ttgacaaaaa caaagctttc tcgggtttgt 1874041 ctgtaagagc tttgaagaat ataaaatatt gcgcagtcac tatcagtatc ttttacgcag 1874101 caggcatgcc tgtcttttat ctgatggccg agatagacga cgccccgggt atcattgtga 1874161 tcggattggt tattattttt gcttcaatgg tgattgcggt ctttgctgct gttcttcaaa 1874221 aactgttaaa agaagcgatt gatataaaat cagaaaatga cttaacggtc tgaggtgatg 1874281 acatggcgat tattatcaac attgatgtga tgcttgctaa gaggaaaatg agcgtaacag 1874341 agctttcaga gagagttggc atcaccatgg ctaatctttc gatattaaaa aacggaaaag 1874401 caaaggctat tcgattatca actttagaag cgatttgcaa ggctttagaa tgtcagcccg 1874461 gggatatatt ggaataccga agtgatgaag acacaggatt cgtaaagaaa aaatatgaag 1874521 gatcaacaga aaaataaagt gattggcggt gagcttatgg acataaactt atatccatct 1874581 agctgctata ctaagcgtcc ctttcataca cgaagaacac aactatggag gaggcataca 1874641 tcatgagagc cataaaacaa atcgtccatt ttggctggga acaagccctt tcatgtttgt 1874701 ttcctgccgt tatttttgcc tctttggcta ttacgcaaat catcccactg cccttcttgc 1874761 cgcggtatga ctggctgctc attatctgcg ttctcatgca attgtggatg gtgcgttccg 1874821 gtcttgagac acgggatgaa ttaaaagtga tcacattatt ccaccttatt gggcttgctc 1874881 tggaactttt taaagtccat atgggctcct ggtcttatcc agaagaagga tactccaaaa 1874941 tatttggagt acctttgtat agcggcttta tgtacgcaag tgtagccagt tatttgtgcc 1875001 aggcatggag aaggcttaag gttgaactgg ttaagtggcc gtcttttttt gcagttgttc 1875061 cgcttgccgc agcgatttat ttgaattttt tcacccacca tttttctata gacattcgat 1875121 ggtggttatc agggcttgtc atcattgtct tttggcaaac atgggttaca tacgaggtga 1875181 atggagctcg ttaccgtatg ccgctcgcac tttcttttat actcatcgga ttttttatat 1875241 ggatagcgga aaatatcgct acgttttttg gagcttggaa atatccaaac caaatcgata 1875301 catggagtct cgtacacctt ggaaaggtaa gttcatggct cttgctagtg attgttagct 1875361 ttcttatagt agcatcatta aaacaagtta aggagcagag tcccacaaag gcagagatgg 1875421 atgaatcttt ttcttagcat acgcatacaa gctcccaaat agagtgaaaa gcaacgttca 1875481 aatggttgct tttttctttt atgtaactct gccggtgagt attcatcttc ttcaaatttc 1875541 atcgcaacac gataactgat tcagattaca actgctttca acactttgac aaactcatgc 1875601 gccgccggcg ttatctcttc aaatgaatgt gcgatgacgc caatatcgcg tgtgacccta 1875661 ggaaagatgt cctttttaat caattgatgc gggacggatg aaagtgtaaa gtttgaaatg 1875721 atgccgatac ccaagttatt tttgaccata ttaatcaagg tttcggcatt ttgcacagtt 1875781 aagttttcct ttaattcgat gttgtattgc gaaaatgcgt ttgacatcgc gatttcatga 1875841 ccgcctttac aaaaaatgag gtcatcttga tatgtttcaa ggtcgacatg cttttcaagt 1875901 tttaattcgt cacgctgcgg cgggatgacg gccaccatat agtcgttaca caatagctga 1875961 ttttcaaacg gttcaaatgg agatgctgcg atcccgatat caaccgtccg atcttcaacc 1876021 catcctttta tttggtcaga ggttccttcg atcaattcta tgcggatcag cgggtagttt 1876081 gatctgaatg ccgcaatcgc ctgtggcatg atatttgttg aaactgcagg aaatgaacca 1876141 attttcacct tcccgtttaa cagcttgttt tcccggttgg ctacttgata tattttgctt 1876201 tcaattccct tcatttgcct cgccagcagc aatatttctt ttccgatgtc agtcagcatt 1876261 aaaccatgat gtttatccct gatcaataat ttgagctgca gtgagctctc caggtttttt 1876321 atcgctttac ttaccgccgg ctgagagatg aacaattctt ttgccgcttc tgtaatattt 1876381 aatttctccc caacttttac aaatatgtga agatggttca tgttcataac catttggtta 1876441 tacccccaat aataaaaatg tatttcagtt atacataaat gtaacatatg atagaaacca 1876501 gcacgatatt ttaacaagaa aggcggcttc attatggtaa aagttatgct gggaatcata 1876561 tctgtcacac ttatttgggg ttatacttgg gttgcgatga aagtaggaat tcatgacatc 1876621 cccccgcttt tattttcggg tttgcgcctg ttcatcggag cagttccttt atttctcatt 1876681 ctcttcatcc aaagaaaaaa gctttcaatt caaaaagaac atctcaaaag ctatatcatc 1876741 atgagcctgt tgatggggct gggctatatg gggattttga cgtatggaat gcagtttgtc 1876801 gattcaggga aaacctctgt tttggtatat acaatgccta tatttgttac ggtgatcagc 1876861 catttttcat taaacgagaa aatgaatgtg tataaaacga tgggactggt ctgcggcctc 1876921 ttcggactgt tatttatatt tggaaaggaa atgctcaata tcgatcaaag cgctttattt 1876981 ggggagctgt gcgtacttgt ggcagcgctt agctggggaa tcgcgaatgt gttcagcaag 1877041 ctacaattca agcatatcga tattattcac atgaatgcct ggcaccttat gatgggagcc 1877101 gtcatgttat tggtgttttc ctttatattt gaggcggtcc cttcagccga gtggacatat 1877161 caggcggtgt ggtcattgct gtttaatggc ttgctttcca ccggctttac ctttgtcgta 1877221 tggttttggg tgctcaatca aatccaagcg tcaaaagcat ccatggcatt aatgtttgtt 1877281 cccgtattgg ccctattctt tggatggctg caattgcacg aacagatcac catcaatatt 1877341 atcctcggcg cactgctgat atgctgcggg atttttatga atacatttac attttcacga 1877401 cggaaagtgt gaatgatata catttcccct gtcatttggg cttcatgtga caggagaaga 1877461 ctattacgag aaagtcttct agaatcctga cgacagccta ttaaacaatg aaaaaagcta 1877521 atgtctgcat gtagacatta gcttggctgg cgtttaggct ggtgagaatc cagatacttt 1877581 tttattacca ttctggctga tcaaactgaa aaccgtatag accttttact ttaacatctc 1877641 cgcaatctgg atcttttgtc aaaatcaaat aatgagtctt ataaggcatc gtctcaactc 1877701 gatcagttgc actaaaatca aaatgatccc ccgagaagtt tttttcacta acggttattt 1877761 catatcctga caaagtcatt cgcatgattc ttgcgttaat tgtacatcct tcagtatcga 1877821 aaatggtgaa tctgtaccca aagtgagatg tccaatggtt tgaatttagg tcatcagact 1877881 tcataaacca tttttcattc tctgtcattg taaaactcac tttctcctca tctttcacga 1877941 taacggccga agcttcccct acatggatag tcaaagccaa aagaaatgta aaagctaaca 1878001 tcaacatctt tttcaaaaga gttcctcccg atatctttta cttcaatata ttggaagggt 1878061 cttttctgat caagacagtc ttctccaaat gaatctttag caccatgaaa tgagccttaa 1878121 taagaacagt tttaacccaa atcaacctct attcgaaata aggcttacca atctatattc 1878181 tttttaaaag tttctgcatt tctttattta gctcctagac acatataaaa aatgctccta 1878241 taagttcagg agcactacaa aaaactgcta aagtgttttc tatcgattta ttgtattcat 1878301 tagctcaaag aaatattcag gcttttgagt cttatttagc ttataccatg aacgcaatgt 1878361 atctggtgca aatacatcta attttttcaa tacttctacc gcaaattcca gaggagcaat 1878421 tcctgatgca gtaaccaaat tttcatcaga tactgcaggc cccttttcat agaatgtttc 1878481 tcctttgtaa ttagggcaga ccatattcat atagtcgagg tcattgcttg tgtgctttct 1878541 cgaatttaag tatccttcat tcgcgaggcc caaggttgcc ccacaaattg cagcaatagt 1878601 cgtgccgagc tttaaagcgt cgccaacttt tttcaagatc ggctgatgaa tatcttctcc 1878661 ccaagtgttt cctccgggta aaatgataag atcttgactc ccaagagtac attcgtcaag 1878721 agaaatatct ggttttatgc ttaatcctcc caacgtagtt atcatttctt tattaacccc 1878781 tactgtaact acttttaaag atgctgcatc ttgtttaaag tatctccctg agtttagttc 1878841 cgcaattaaa tatccatatt cccagtctga cattgtgtga aatacgtaga gataaacttt 1878901 tctcgtttgc atccaataac actccaatca caattgataa agctttctaa tagatgactt 1878961 tgctgacagt cattgtcagc ttttttgttg attctattct tatgcccttg ttctcccaac 1879021 ttataaaaat ataagatcaa ttgattctat gtttactagc gcaaaggggt ttgttacact 1879081 aactgtcatg ggaaacattt caaaggtaat acaaaatcat ttgaatgagg aggcctgatg 1879141 aagttgaaaa ctaaagcgtc aataaaattc ggaatatgtg ttgggctttt atgtttaagc 1879201 attactggtt tcacaccttt tttcaactca acacatgccg aagcaaaatc catagaagac 1879261 acaaacatgg caagctgtat aacgaataaa aaatttgttc aacttgagaa aaaatttgat 1879321 gccaggcttg gtgtttatgc aattgatata ggttcaaaca agacaatcgc ctatcggccg 1879381 aatgaacgat ttgcttacgc atcaacctat aaagttctag ccgcagctgc tgtcctgaag 1879441 aaaaactcaa ttgaaaaact taatgaagtc atccactaca gcaaggacga tcttgttaca 1879501 tattctccaa tcacagagaa acacctagat acaggcatga gcctaaaaga aatctcggaa 1879561 gcggctatcc gttacagcga taataccgct gggaacatct tgttgcaaca gcttggcggc 1879621 cctaaaggtt ttgaaaagtc actgaaacag attggggatc atgtaacgaa agctaaacga 1879681 ttcgagacgg atctaaactc tgcgattcct ggtgatattc gtgacaccag caccgcaaaa 1879741 gcactggcaa ccgatcttaa agccttcact ttagataaca ctctcacgac tgacaaacgc 1879801 atgatcttaa ccgattggat gcgaggcaat gctactggtg acgaactgat tcgggcaggc 1879861 gctccaatag gatgggaagt cggcgataaa tccggagccg gaagttacgg gacacgaaac 1879921 gacattgcta tcgtttggcc gccaaacaga gctcctattg ttgtggcaat tctgtcaaac 1879981 cgctttacga aagatgctaa ttatgataat gctcttatcg ctgaggctgc aaaagtcgtc 1880041 cttaacgatc tcaaataata tgtttagcct tttgccacaa aggaaaagac attacttttt 1880101 taacttctac cgttcatttt ttgatgaacg gttctttcat aagacctcta gaatcatata 1880161 tttaaacacc acaaaattaa acattattat aattaacagc aagttttcat tttatggaac 1880221 aagtaaagtt tgaatctgac aagaattaag actaagcacc ctaaaatccg ttttcttttc 1880281 ttccaagaat atactcctta gtgcaagcca ttataaagat acaagtgaac atacaatgca 1880341 gacaactctc ttaagtctct tattctgtga ccaatttgta atactcatga atatccggac 1880401 tcacttccaa tatttcgtct cgttcgaaga cactaacata tcaaaccact tgaattaaca 1880461 taactgaact tgatattggt cactggcagt ttcaatgcaa tagaacaaca tttgttgtct 1880521 cagaggttat ctatatgaga attcaacaat ttttttataa taattcatat ttttgtatcg 1880581 ttgcacttgg tggatttgac tcttttcgtg tatggaacca cacttttatt ttttcacctc 1880641 ttttgagatc atctgtgtta tcaatctcac ttaatcctac aattactatg ttatttttaa 1880701 acttgttcat aagttgtcct tcagaaagat tgtaatcttc ttttcctgga gcttttgtat 1880761 cggtaatgag aattgccctt tcattgtctt taagcacgac atagcctact aggctctgca 1880821 tctttgtttc gtctccgttt tgttcatttt tattgcagcc tgcaaggaaa ataatgagca 1880881 taatgagcac tatcaagctt actccgattt taggcatctt tcttcctcct ctttaaactc 1880941 atctttaaaa taaacaacag gatatcaccc aacccatcta cttctttttg caattcataa 1881001 cagcagcata ctcattctcc aattcctcaa ccttcttttt attctttctc aaatatttgc 1881061 atgtggtagc cctcgatatt atccgcttac tcatttttgc gctttcaaat atattattga 1881121 aggccgcttc tttctggatt ccagcataaa tatacttatc cttactgtcg tttactatcg 1881181 caacttccat taaaatcgag atttttactt tttttatgat ccattattca cttccaaaat 1881241 aacttccaat tacaacataa tatatgtata aattgtaaat ggagttgatg taattgaaga 1881301 ttaggaaaat cttattgagt tctgctttat cctttggcat gctaatatcc gcggttcccg 1881361 cattggctgc tggcacttcg tctgaggttg cagtaaaaaa tgaagaatat gattatgaca 1881421 ctatataccg cattagtcct ctgccaatgg acttccagcc aacaatagaa tacaacggtt 1881481 atacttatac gcttacacgt cattattttg attactcaat cgggttttac acggctattt 1881541 atacaaaagt tgtttaaact tataaaggag ctttttagct cctttttctc ttgttttaag 1881601 caaggtattt ctttctatgt ggtcccctat caaatacaac atcaacattc tccagttctc 1881661 tttgacacga acaaaatcta aagtttggtt ttaaatgctg gtaataaaaa attcacttta 1881721 aagaagtgcc gcccgcaaaa tacggctttt gtacactacg ccaattttat attgaaaagc 1881781 cagacctcct caaagaggtt ccagcttttc ttaatgtgct atcgatcttc gttagttcaa 1881841 cgggaacttt atcattcggt acaaatgcag cctcccaact tctagttagg gctgatggcg 1881901 gaatatctga cggttctcta cacacatcag acattagaag atttcaatgt agccttctgt 1881961 accatgaacg cgaattcgtt gcccatcttt tatcagcttg gcagcatttt caacgccaac 1882021 aactgcaggt aagccatatt cacgggctat aacagctcca tgggtcatca gccccccaac 1882081 ttcggtgact aggcctttta tggatacaaa caatggtgtc cagcttggat cggtaaagga 1882141 ggtaactaat atatctccat cttctaaatc cgcatcttcc atgtttaaaa tgacacgcgc 1882201 tcgcccctct ataactccgg aggaaacagg tagacctaca atcgctccgg ctgggagatt 1882261 ttctcgttta tactcacctg taacgatttc accatcagac gtgataacac gtggtggaga 1882321 tagtttttca tataatgtgt actcgtcttt tcgtgtactg atgatttgat aatccagttt 1882381 atgtgtgcgc acgacttcgt gaagttcttc aaaagtgaga tagtatatat cttctttttc 1882441 atgaataacg cccgcttcta tgagttgttc ggcttctttc agtaaagcct gcttataaac 1882501 gaagtatcga ttaaccatgc cgtattttgg atattcccta aacccgctga aattccggat 1882561 gatatctatc gctcgttttg tttctttggc tttttgttca ccatccggta attgcttcaa 1882621 tcgatctaat aactcttgtt ctttcttcaa agcttcctgt cgcccttgct caaatttccg 1882681 atggccgaca ttaggctcaa aatttttaat attattaaga atcattggga caagtgtagt 1882741 tggtttttcg ctccatcgag ttcttgtgat atcaatctct ccggtacatc gcattccgta 1882801 tttgctgaga taatcataga tcgcgtctcg ggttttgctt ccgccatcaa acttagccag 1882861 ttcatccaaa aagttatcat cttttacatg ttgtaagtaa tcaattacct ctggataagg 1882921 acgaatcaca tctgcgacgt ctaatagcgc aagacccatt tctgaagtaa tattatgggg 1882981 tacagattga gaaagcgtat ctgctgcgtt tttttcacct aaccactcgt tcattttttc 1883041 gttaatccat aatgaagcat tcatagcagt tcgaattaga accgaacttt ttgggttaaa 1883101 taaaatcttc tttaattcct gaatatcttc cagaataaaa cgaaataaat ctgatcctga 1883161 tttcgtttgg atgttttgtt ttaactcttc tatcgatgtt tgactgctct caatcaaatc 1883221 agacacgatt gtcggatcgt tttcaacttg agccggcata tctgcattgc ctctgctggg 1883281 atttggtgct gttttatcat ttggtatcga ctttatgaaa tctcgtcgct ttattatggt 1883341 cataagtgcg tcttttaaga gctgatcgtg ctgccccatg ccttttaaga aaacttctct 1883401 gctgtcaggg gatgccagat gatgtgtgac atcaacaaat agccttccac cggctttacg 1883461 catgggtgca acagtcgtca acagaaaaaa agacaatccc agtggtttta tgggatccgt 1883521 catcatttgt tgatgaccaa cagaaatata gacgtgattt tcttggtcac tcgcttcagg 1883581 gatggggaat aaagtagtga ttggacgact ctgtacaata taaaaagtat cgcgggccaa 1883641 acaccattcg atatcttgcg gctggccgaa atgagcttcg atctgtcttc caatgcgtgc 1883701 cagctgtaaa atttgttcat cagtcagtgt ttgagccttt tgctgatcag aatcgatctg 1883761 ctgtgtttct gttccgcctt cttttcgtcc gtagatagcc atttttttag ttgctattct 1883821 cttatcgatg atttgcccat cctgtacttt aaaacaatcg gcagatacca agccagaaac 1883881 cagtgcttca ccaagtccaa aaccggcatc gatggataac acctttcggt tggaggtaat 1883941 cggatcagcg gtaaataaaa tccccgaagc ctgagggaaa accatccttt gaacgataac 1884001 ggataaatag acttggctgt ggtcaaatcc attttgcata cggtaaataa ccgcgcgatc 1884061 cgtaaatagg gacgcccagc atttactgat atgctgcaag attgcatcga cgccggtaat 1884121 atttaaatag gtgtcttgtt gaccggcaaa agaagcatgt ggtaaatcct cagcagtcgc 1884181 actagaacgc acggcatagg catgttcctc gccaaactgg gagagatatt gagccactgc 1884241 tttcacaaca tcggaaggaa tgtctacttc cataatgatt tgccgaatct tccggctgat 1884301 gttaccaatc tgatctcggt cctcaacttt tagcatggtc aattgatcca acaacacttg 1884361 taacgtttcg ttttgttcga tggctttttg atatcctact gttgtgacac aaaatccttc 1884421 tggtacttgt ataccttgaa tttttgataa ttcccctaaa tgtaaccctt ttcctccaac 1884481 gagcgaaagc tgtgtttttt caatttcatg taaaccgaga accaaagaac tcattctaca 1884541 tctccccttc aaaaaaaaat attgacaaga gcttcctagc aggatataat aaaattataa 1884601 gatggatatc tataactttt taactagaaa gcgcacgtag tgtgattata tcaccgtgtc 1884661 tgtttttgtg caatataaaa agaacctggg aaatttcacc aggttctttt cttaatttcc 1884721 atagctagtc gcattaaaaa acttggtttg agctgattca atcctctaag gaaatcctaa 1884781 agttgggttc tttttgaact tacttgcttt gttcgtagag tccccattca taaattggac 1884841 tttttgttct taacagtccc acctttaact agtataaagt tatgaggatc tggttaacta 1884901 ctagatattt ttattttgaa taaggcttat gtttgataaa gaagggttat gtaaaggtgt 1884961 ctgttgtgag caagcgctga ctacaaaaaa ttgatagcat tctcatttaa ataccattct 1885021 attaacctat agggaaagtt ttaaaaccag atggagaata ccctacctcc agcaattcca 1885081 aggccgttca cctagtagaa aacaaccttt aaccattact aacgatttta ataatcattg 1885141 attataaaac ttctcaagga acgatcagca gcccgttagc tacccctgat taaggatgat 1885201 ctgttaccac actgttacgt tagaacttcc actactttga tatccttctg tcgccatgac 1885261 ttggtaagcc caattactgc ccagattcat tccatggctc ttccatgcgt tcacatgatt 1885321 gctgaaagtg attgtagcgt tgcttccggt tggtctcttc gactggcgaa cactccagta 1885381 ctgcgtaaaa gtagtgcgat cgccatcaat ggaaggtgcg ttataacgtg tagttgtata 1885441 tatgtcatat gtacccccat cactttttac agtaccttta tacgttccag taggtctata 1885501 agtaccccat gaatccacta cataatattc tatgagaggt gatctcgtcc aaccatataa 1885561 agttaaatat ccattgccat tcggcgccca aactccggca ttatagttta tcgtcctaaa 1885621 tggcgaacct gtagtccaac ctttaccaac aacaaaattt ccggtattag accaattaac 1885681 actgtaattc ccgccagacc cattgacagc gtttactata ccgcccccat cagtccaatt 1885741 ttgccagtag tctgtgctag ctgcagaggc ggttgccgaa aacaagctaa tactcattaa 1885801 agctgccgat aatccaacta agaaattctt tttaaactta aacatatgtt acctcctata 1885861 atattttttc cgactttgag gtagcactcg tatacattta aaacattctt aattactaac 1885921 gccaaagctt ttgatcgtcc ccttcagtat aataccacga attcatgagc aaatattaaa 1885981 agtatttgta attcaattac aaatacctag aaacacatta taagtggtct tcttccacca 1886041 tatcctgatc cttttttcgc aggatcacaa ttcttgtttc taattcagat ggagtaatat 1886101 ctgcaatgaa ttcccattga accatttcaa ataaaggaga tatacattag agattgtgaa 1886161 attattgtag ctgccgcttg tctaatgaag ggaagcaaat ttatgaagaa tatgaagaac 1886221 tgaagaagaa aacaattaag gttatactaa gaaagaactg ctcaattaaa attattgacc 1886281 aaatttgagg atgatagctt agatcagttt tacaaagaag ttgcaagatt tttatttgaa 1886341 agggctctga aaaagaaaaa aaagaattga caatcagggt aactgtggga tgtaaccgag 1886401 cctccaattc aaaataaata tctttaactt tcttttttta tttaaagagg gactgtatat 1886461 ccctctttaa aattaagctt tagattgctg ctgaaagtaa taaaaattgt acttttgatc 1886521 aaacccttct tcgctaccac aaagaaaaat aatgaattca ataaatgcga taatagaggg 1886581 gataccagtc cagcaaaaca aaatatatag aataccttgt cctactcttc ccaaataaaa 1886641 cttatgtatt cccagacccc cgaagaaaaa tgctaataat gccgctacaa ttttgttctt 1886701 cttgcttacc atgacttcct cctagttcat tgctaccatt tttaaagtaa tgctttcaca 1886761 ttataatgca ttttccgcca gaaatcgtga aaattttgaa attcttttga gattttttat 1886821 tttattgaga aatgaaagct catataattg aactagatgg ttttgggagg catttattca 1886881 aaatgtattg ccaaagatta cggcaattac gaaaggcaca caaattaaca atggaacagt 1886941 tagctgagaa aattggaatt gcaaaatcaa gttacggcgg gtatgaagct gaaagcaaaa 1887001 aaccaccatt ggacaagttg gttattttag ctagactata tgatgtttca gttgattaca 1887061 tacttggatt aacagatgat cctgatccta aagtggaaag aaaaaatcta aaagagtttt 1887121 tagaaaaacc agatattcac tgggatggat ataaacttac ccctgagata ttagatccta 1887181 tacggaaaat tttgaagttg gttactgcaa acaacaatta aaaaagccct cataagggct 1887241 tttgcataaa acaattattt cattgaattt tctggactca tttcaagaag tttattcatg 1887301 atgatagcta aactttcacc agctttttgt agcttctcac ctgcttttat cagagtaatt 1887361 aaagcactta aaaagtccac taagctattt tgatttattg caactgtttc tttataagct 1887421 ttgtaagctt cttcaaactg atcaaattgc acacctttca tagcaacaac agctaattta 1887481 tctgaaatat ttccatatga ctctgttaaa ctaaaaaatc ttttgacatt gattagtaag 1887541 gcaatgcact ttaaataatc gtgccccaga ccaatatgta aattgcctgc agcaaacagc 1887601 aaatcgttca aaactgtgta cggttcacca ttccttgcaa ctgtctcaat ccctttgtat 1887661 aagtataata aaaagacaaa tgaattttta tctgtggaac gctcaggtaa taaggacact 1887721 ataataactt actttaagcc aaaacatcca aataaaaagg ctggttataa ttattataaa 1887781 aatcaatagg aactataaat atataaagag ggattgctat gccaaaatta tatacatgtt 1887841 taatttgcgg atataaagga ttaattcaaa acccattaaa caatgatggt gagtatcaaa 1887901 aaacatttga tatctgccct tgctgtgatt ttgaatacgg ctacagtgaa gatcatgacg 1887961 taagcttagg ttttattgta actccagatt atttaattga cgctgcaatt cagttatacc 1888021 gaaaacagtg gattgagaat ggaatgaaaa ctgcaaatcc tgaagatatt ccagaagaat 1888081 taagaaacgg tgactgctta aaattcgagg tgttgttaaa gcaattgaat agcctaaatc 1888141 tcgatactga aaactttgaa atcaagggat ttaatggtta ttaagcagat ccaagccccc 1888201 atatgggggc gttcttatta ttgtacagtc tatcagaact atttatagaa aaactattta 1888261 atgtattgta taaatatcac tgaccttttc tttctccatt caacttcctt aaccctcaac 1888321 tgtttgctgc tgcatcacat tcctcctttt tgatttttgt gtatcaagcc tgtacaatat 1888381 tcaaaaaccc taaaggatga tgaacatgtg tggcaagttc actttatttt ctgagtttga 1888441 tgacatcatt gagcaattca acatagatca attcttacct gaaggtgaat atcaccctag 1888501 ctataatgtc gctccttcac aaaacatcct gacaattatc aacgatggat ctaataaccg 1888561 tctgggtaaa cttagatggg gtcttatccc tccttgtgct aaagacgaaa agatcggtta 1888621 taaaatgatt aatgctcgtg ctgaaacatt ggccgagaaa cccagctttc gaaagccgct 1888681 cggaagcaaa cgttgtatca taccggctga cagtttttat gaatggaaac gccttgatcc 1888741 aaagactaag attcctatgc ggattaaact taaatcgtcg aatctctttg cttttgccgg 1888801 cttatatgaa aagtggaaca cgctagaagg caatctgttg tacacttgca caatcatcac 1888861 aataaagcct agtgagctta tggaagacat tcatgatcgg atgccagtta tcctaactga 1888921 tgagaacaaa aaggaatggc taaatcctaa aaatactgat cctgattatc tacaaagctt 1888981 gttgctgcct tatgatgctg atgacatgga agcatatcag gtatcttcat tagtgaattc 1889041 acctgagctc attgaatccc attaagtacc actgccatat cgctttatat accacctcct 1889101 cttagctaat atgttctaag taggaggtgg tattttgttt gtatctccaa tgctattgca 1889161 ttcaataaaa gagccttttg atgacgagag ctatatcact gagcttaaat tatcaagact 1889221 aaaattaaaa taagggctca tacatagttg atatatataa tatgtattga gacctttatt 1889281 gaacaaacgc cccgtttgtt aaagtggaaa tctctataat taatagccga cttttaaaag 1889341 ttccaatcta aaattatcct ctaaatcggc tagcttcatt aacttctccg atataccttt 1889401 ccaatcttta tttacagaca tagaatgaca tatcccaaac accttagcct gttcagtctt 1889461 caacactgat aaatgtgaat gcctatcttt aaaatacatt gcataatcgt tggcccttct 1889521 tgcacttaat tggaaaagga agaatgttgt atgccttata gtatcagctg taataggggc 1889581 atttaataat tgatcagcat aaaaacaaat tgcttccctt ccaattaacc ctatatccac 1889641 tttttcgaat ttccgataag ttctcttaaa ataatcaatt gctctctcgt atatttcgtt 1889701 attgtctaat gtgacaacct tttttgctgt agaccaatat ttattgattc ctttcctata 1889761 cggaatcctt tccgccatcc aagccttctt aaattggtcc agtgataatg gaacaaatgg 1889821 aaagcctgct ggatcttgca cataaatatt ttcattatcc atttggtacc ctagaacata 1889881 atggtcagaa ccatttaaat ttttatgatt cggatggtat gttagctccc ccatatctaa 1889941 agggcctaga atgacagggt tttgtttgat ttgctgtttt aataacggaa atgggtcatc 1890001 taagtcacta gcttgctgat gttcttctgc agtaaatcca aggatgttta aagcataatt 1890061 gataccatca tcaggatctc tcatactaaa ataaaggttt ttttcatatt ctatcatggc 1890121 acctaaccca acaccagtta atatctctac aagttgagga gatacatttt ctcctattga 1890181 tgaaagaaac attgcagttg aatttgaata acagtaatgg ccatttccta tatacactaa 1890241 catcacctcc gggtagataa gttaacctta caattttgaa aattgaaaat ccatattaaa 1890301 ttgctccgtt ctcgtattca tcatctggat catttttatc aacaataatg atcttctcgc 1890361 caatctccgt tttacgatcg acctctacgt attcgcgctt gatgctgcta agtgtttcgt 1890421 cagccagtac gtgaatcatt acagttgagt tcgctttaat ttccgtcatt tactgcaccc 1890481 tttatatttt ttttatgttt tttcaattct ttttagattt tcatattgga tttcactctt 1890541 ttaattatag aggcgtgtca tacacatgcc atctaagaga gataggacaa ttttgtcttg 1890601 gaggtgaaag ctaatgaatt ttcttcttga tctttttaca aattggactt ttgataaagt 1890661 cctggattat acactagctg ctgtaatttg gtctgtattt aaatccagat caaagcagaa 1890721 taagtatcca ggctatttcg agaaaatacg ccgctataga aatttacatc cccttctgcg 1890781 atcgttatcg atgcgtgtac ttttatcgat aacgatccat ccttatatgt ttagttaaaa 1890841 actatctttt atttagactt aatgggataa aatcttcatt gtaaaactct tcccactcag 1890901 caattaagtt tctataatag ttttggttag agtcggttgg catagattca atattgtcaa 1890961 aaccattaat accgacatct aattctactg tcactaatcc ttggtaaaac ttcttataat 1891021 tctttttaat tactttgaaa aattcaacat caaagaagtc ttcatattca gttgctccac 1891081 tccaagaatc ataagaggac ttaacacgat aattaaaaag aaccaaaact aactcatctt 1891141 tcacatcttt tgatatttgc tccattaatt gatttagtcc ttcactggca ttaaaatcta 1891201 caatgcttaa tcggaagtca atccaagtaa cagcttcatc ttttaacctt ccttctccgt 1891261 cttcattcac ttcaattaat acatatctgt cagccataat tccctcctaa tttatttgtt 1891321 taaaatcacg attttaacta tttatgatcc attagtcact tccaaagcaa cttccattta 1891381 actcataatt aatatataaa atgtaaatgg agttgatata tttgaacctt cgaaaaattt 1891441 tattgagttc tgctttatca ttaggtatgc tggtatctgc tgctcctgtc ttggcaacaa 1891501 gttcttcgtc tgaagtgata gtaaaaagtg atgaatatga ttatgacacc atatatcagc 1891561 ttagccccct accaaacttc aagccttcta ttgaatacaa tggatatact tatactctca 1891621 cacgttatta tttcgattac tcaattcagt tttatacggc tatttataca aaagttgttt 1891681 aaacttatag ggagcttttt tagctccttt ttcacctttt taagcaagat atttctttct 1891741 atgcggtctt ttatgtatga aatcaaatgc tttccctaat tccttctctt ctgttaccgc 1891801 tgagtccata tcttatattg catctaaggt ttagtcagtc gagatcattg aatatatagt 1891861 actttactca gaacattttg cttattaagg acataataag tgttcgtatt aatttttcct 1891921 gttacgataa cgatcaaaaa caaaataatt tatctcattt taagacagaa gttattctgc 1891981 tttttcaaaa aaatattctt gattttccct tttttagatg catccataaa gcattcgatc 1892041 ataaccatta tatgtaactg aaatgcaggt ataagagtta ttatataggg attacactac 1892101 cattatctgg gggtgtatta acatccaaat actcaaaagc aagaacaaat gtacccatag 1892161 cacttccatt tccacaccct atccaaattt tcattttcct aattccacat caaaatcacc 1892221 ctttttcaca tcgtaatcac tatcgtaaaa gcctatagta tcaacgtttt tccttcttaa 1892281 aattttcttt ttttataaat atcttcccaa aacaaccact ttcccctact cccgcttatg 1892341 ttttacgatc gtttaccccc tatttactaa ttaaagtatc aaaaattctt atgtttactg 1892401 tctttttagc tcattataaa tttttacgat aagcaattgc ctttgctttt ggatatgact 1892461 tgactgtatt tggtgacgat ttaacagaga aatttaatgc tcttctgact tttttaactg 1892521 cattgggcat tattgttgat ccaacaactc aaggtatttc tgatagtgaa caagcaatgg 1892581 attatgattc accgagataa accccatacc cttctcttga ttgaggaggg tatttttttc 1892641 gttttttcaa atgaaaaaat tgcagaaaac tttacatcct tttacaattt tttcaatgac 1892701 tatgttatga ttgttttcga gagatttttg aaattttcag aaagaggggt ttaaatgagt 1892761 aagatcgctt ctgaagttgt cgctactaca ctgaatgact ggtacattgc tataaaaaaa 1892821 caaaaggttg atgaatcaat aaaatattat tcagagataa agaaactttt tgatgaaatg 1892881 gaagaagatc aagaagttct tgcgtattat agtctattag aagaaagaca taaaatgttg 1892941 ctgcattctt cacgaggaga gcctttacaa aagcacacct attttactga agacaatcaa 1893001 aacttcataa caaaaacaaa tgataaatta gaatacaact tttatttatt tgaagcaatg 1893061 tacgaggcat acaacaaaaa ctatgatcga gcaattaacc tatatggatt agctgagaaa 1893121 aagcttgcag aaattccaga tgaaattgaa gcagctgaat tttactctaa agtctcttac 1893181 ttatatactc ttgttaaaca aagcattgtg gcacaacatt atataaaaaa tgcaatttca 1893241 atatataagc gacaccctga ttataaatgc aaactagcta catcaacaat gattgcagct 1893301 gcaaactatg ctgatatgaa acgatttgag gaagcagaac aatattactt agaagcaatt 1893361 gatattgcaa aagaaacaaa agatgaattt ttaaaagctc aattatttca caatcttagt 1893421 atcgtttatt ctgattggaa caaacctgat aaatgcattg aatctcttga aaaagcaata 1893481 ggaaatgaat cttggttaca ttcgatttat tatataaatt ctttattcat gatgattaaa 1893541 gaactcttta aaattgacga aaaaatgaaa gccattaatt tttacaataa agcacaggaa 1893601 agactcatat taatggagaa taaagtatac gaagccaaaa tcagcatcct gtataacctt 1893661 tattgtgggg aattaaaaaa taatttcaat aattgtatta gtaatattga gtttttaaaa 1893721 cagcaaaatg aacttgaaag tgtagatgaa ttgtcctaca tagctgcaaa aaggtttgaa 1893781 tcaataggtg cttttgaaga agcaacgagc tttttcaatg cgaaaatttg ggctgaacag 1893841 aaaatgaatc aggtggaggg aatcttatga aaaaacttgt gctttgcgta tctattttag 1893901 ctgtgatttt aagtggagta gctttaacgc aattgagtac agattcacca tctaacatcc 1893961 aggtagctga aaggccagtc ggaggttaaa aaaggttgat taattaattt agccctactc 1894021 aaacatttga gtgggctttt attttatgat ttatgtccac cggtcagccc tgctctgtgg 1894081 agcgcagtac ctgcaaacgt aactgagata cttctcactg ttttttgccc gagtaaaact 1894141 tattaaagaa catcaagcaa cacttataaa tatccatcgt gatatttgtg ggaaaatcaa 1894201 ttgttttgga tcgatgaaaa ccaccgccaa gctcatcttt actgtatcca attcctagac 1894261 ttattgttcg accaacttta ttatatgtac gtgcccttct tgcgacttcc tcacaaatct 1894321 ccaagagcac agctttaatc tcttctctct ttgtataatc cctaaacaaa atctgactct 1894381 taccaaaact aatctgcccc tgcatcaatg gagctcctat ttcagataaa tcaattccgt 1894441 gagcatgata gtacaactgg tttcccatta ttccgaactt cttttcaagc agctctaaag 1894501 gaaatttagc taactgacct acagttgata tacccattcg attcagattt ctttccatcc 1894561 tccctcctat cccccacatt ttagacaaag gtcgaacttt ccagagtcta tttggcacat 1894621 cttcatatct ccaacgtgca ataccactct ttgttttctt actctccagg tcaagtgcaa 1894681 gcttactaag caacatattg tcaccaattc caactgtgca catcaaacca aattctctcc 1894741 acatgctgct ttggattgct ttggccattt cttcaggatt ctcttttcct gcatctaaaa 1894801 aagattaatc aattgaatac gtgtggacac atttttcagg aacaaatctg taaaacagct 1894861 ttgtaatctc agttgaaact ctgatgaaaa gcttcatttg tggatttaca atgtatattc 1894921 ttggatcttc aggtatctca aatagtctcg atcctgtttt gattccaaaa tcttttttaa 1894981 gtgcaggaga tgcagctaac actacacttc cctgtctatc cgtattccct acaacggcaa 1895041 gataacatgt taaaggatta agccccattg ctacagccga tacagaagca taaaaggatt 1895101 tcatatcgac acagagtata ttctcacgtg gaaattgtga gtaatcagtc attgtatata 1895161 actcttatga tgttattcat gttgatataa actgtattgt cgttctggtc ttttacgtga 1895221 agcttttgtt gttcaaaatt aatgtaatgt actctgccgg taacattttc aacaaatccc 1895281 ttgttaaaga gtttgaattt caactcttta ttaaattcca atgcctcaga aacgagaata 1895341 tccatctcat caatttgttt gtcatctaaa gatggctttt caacttttga tccatcaatc 1895401 aaatcttgtt taagctgtat taattgttct agcatcattg atgtccattg atagttcctc 1895461 gatccctaaa catatcgact cactccttga ttgatctaat atcaacagaa caaacgttcc 1895521 ttattcaata tagatcagaa caaaagttcg atgtaaatgt tggtaataaa atataaaggt 1895581 caataatgat atccgtagta ttaataaagg agagattctt ttcgacgagg gagagtgtga 1895641 tggtgaatga agaagaggtt aattggattt ttggtcttag ttcctgcttt gattatgtgg 1895701 ggtataactt taatcgaatc aaacaaaaag acccctgtag aagttttaga aagtgcttgg 1895761 gatgaatttg ggttatttag ttttgaaatt ggaataacag atccggcaat tacaataggc 1895821 atggatcaaa ccaaaagtga agcaaaactc cgtgaatatt taaaagataa tctgtctaga 1895881 gaagccaagg aaaaatataa gatttatata ttcaaggatg atactgataa gctggagaaa 1895941 gagcatcaag aatatttgaa agaaaataat ctcaataagt aaaacgccca gcaattaaaa 1896001 ctggacgtta aaaaacatta gttattcttt attttttttt agtattcaca cgtaatctct 1896061 ctctatcttc tttaaaagag gatatgtagt ttttagactc taatgcagtc accaacgctt 1896121 tattagttct attatttgag atctttattc gtctgccttt ttcagcaatt tcagagtaag 1896181 gttcccctat tttagttaaa aattcagtaa ttgattcatt atcaatatgc tttatttgtc 1896241 cagctagcaa cgataaccta gtatccaatg ttgtaggtga ttcaagcaaa aaggttagta 1896301 gttcattggt gattttcagg ttatgctcat taataaaata aattgtatct ttaagaatat 1896361 cattatttcc atctgtcaaa cagttagaat ttaaatgttg tacaaatatt tctttgttaa 1896421 attgagagag ctcgttgcta tctatgagtt gctttatatc attggcatca agggaaaaat 1896481 caccttgttt atcaataaac tcgtcagggt ttctcaaagc gagttggata tgaagtgtat 1896541 caaaatttaa ttttaactct ttaaaatttt ccggtgttag agataacaaa tcattatcaa 1896601 tcaataattt tgctcttttt tcactaacat ttccgagcgg aaagtaaatc caactttgaa 1896661 tactagcaat taacacttcg aatgtttcgt ctgtaatatc ccgactatta atgatttctt 1896721 ctgagatatc ttctaaaatc gcttcgtcaa atttatcatc aaacgcctct atattatttt 1896781 tagagagctc ttttctatta acaggattgt ttaagaaagc tattaagaaa tcaggcattt 1896841 ttttattgta ttctacataa gaagtaataa cgtttgacca gcatgcaacc attttatttt 1896901 cacggatcac aattggccat aactctttaa tcaattcacc aatatccgag atggcaaaag 1896961 tttttttcat gatcattgca tgctttactc tcttatctaa atcctcccga tttaataact 1897021 ccagaaaact ttcctctggt tcctcaatct cctcagtaag taaaactttt tcaacaaata 1897081 tatcaatatt gtcatttacg taattgataa cagcctgctg atcagagttt ttaactgcag 1897141 catacgttat attgggagca tcatttaaaa taactgataa agttttgata ttaatttcgt 1897201 atagatttcg ttgaacaaca aagtcatata ttgtttcaga atttagcaaa tgatccaaac 1897261 ttttaaattt aacttggagt tttaatagta gttcttttat tttctcctca tcagatacta 1897321 agctgagaag atttaagtac ttggataatg tgaaagacat gaccgactct ttattcattc 1897381 ggataatatc agctatatca gcatatgtaa gtatatctga caagtattcc tcttttttct 1897441 gttgtgtata attggatcta agttcaataa aactccaaaa atcatcccat ttactagata 1897501 tcgattggat aaaggcagct ttatttattg ccctttcttt aaaaccatct atgaatgtaa 1897561 cagattcttt acttccattt gcaagtcgct caattatgct atcataataa ttacggtatt 1897621 cagaatgatc cattatatag tttaagagat gaaaattaag tacctctatt tgcttaaatt 1897681 cagcaccaac taatttgctc attattttac cgatattatc cagctcaaag ctgtaaggca 1897741 atgactcgtg gtttttaata ctaaatacaa atttaatatc ggaaagactt aaactttctg 1897801 gatagaagta agtgatgtaa tggttataca tttcatcaat atatccatga cgtagcaggt 1897861 aaacaagtaa ttttttctcg taaagcttat cagaaaatac atcctttgaa ttcatttttg 1897921 taattaatac ttgtaaagat tgcgctctta tttcttgctt ttctctctct aattccaata 1897981 gttctttctt gaatttttgg atttcatttt tctctatagc cttgatggca tcttctcttt 1898041 caaagtagtt cggtttccga ccaaaaacag ttgcaatttc tttaattgtc gctggaccat 1898101 ttctatttct taaataacaa tagatagtat ccgcattttt taacttctca aaaaaccgat 1898161 ctttattaga tgtattgcct ctaaatacct cgccatctat attaatatca taattagaat 1898221 tcaaatttga tatttctaat tcgctcaagt atataaaatt taattcagca attgatttta 1898281 aagactcaac ttctatattc gctaatttcc tctctaattg ttgtatttta gcattaatta 1898341 attttatttg ttcctcaatt ataagttgtt ttttttgaaa gatttcatat accaaccctt 1898401 tgttatattg taatttagaa aaatccacag gataaatatt tttgtagatt atcattgcta 1898461 acattttgtt aggatcaaga tcaattgcac ttagtttttg ttggtatata acaaattcat 1898521 taaaaatatt ctttaatact ctcatgtcat caatgtaaat tgttacatcc tctaagaaat 1898581 gagtgtttat caaatcagaa tatggtgaat gttttatttt ctttttaagt atgtctcctg 1898641 aattagatgc attaataatt ggtattactg ggataataaa atcaaaaaat tttgtgcggt 1898701 ctctagttaa cttttcagtg tctgcatctc caaaaatatc atcttttatc gcatatataa 1898761 aaacaacacg tctatctatt tgttctgaat tatttataag ttcatttaat tctcttaatc 1898821 tttcaaaaat acctatatta ttaaagcgat ctaagtcctc aaatattaca acattatact 1898881 tggaggcttc aaaaaaatat aatatttcat ctaaatattt atcaaatata gaagagtttt 1898941 cttcccctgt atttttttct aacgttgtat tagcaattgt aaccttattc aattttaagt 1899001 tggcacggac aaaatgataa attcttttat atgcgagtag aggatatact ataaagaaca 1899061 gtgctaataa tatagtcagt cgtatttgtt gctgatcttc agtaccgaga ctccttgaaa 1899121 ctaacgtctc agcatatatt cctttaagtg catcaggttt aaaaaggtag atgccaacta 1899181 taataaatgc aaaaaagaaa atcaaattta taattatgct cttagtcctt atatgcttaa 1899241 ttcttttaaa cctagaaaag ggaatggttc tatcgtgtac ccggtatatc atttgttgca 1899301 agatgctttt ctctaactta ttctccatat catccgtatc tgtgttgaat gtagctaagg 1899361 atatatttaa gaaactatat tccctgctgt attgtttttg aaaggtattt aatatgctac 1899421 tttttccaga cccgtaggga ccagttaggg cgatattttt cactttttta ttttctaacc 1899481 cccaacttag tgctttagaa tattttccat cagtgtcgac atcattgcta ggagaaagat 1899541 cttcaaaaag gctttcttcc ttaacattag gttcttttag tctaatcaga agtttctcta 1899601 accactgcac aaattttttt ttgatttccc ccaaaaaaaa caaatccttt ctaaactttc 1899661 aggtgtaata cgaattaata aaactggagc aaagaactaa ataaatgagt atgtagcaat 1899721 gacaaatcat ttctcttcca tctaatatag tcctttatcg ccagttgaaa ttcactatta 1899781 attgtaacat gaaagggcat taaaagtttc tgaaaaaaag atgatcaata aacaacacag 1899841 cgcccaatta caggactgtt tcatatttaa attgaatttt tataagcatt aattgcttca 1899901 tttcgcagca gcatattatc tttgttaacc atgcctaagt tgtaagcttt tttgataata 1899961 tctaatacct gagaatctaa cgccgaaaga ttaccgcctg gattaaatct tgatttccaa 1900021 taatctaaag aattatttag gtcaagtgag ctttttttgt tctcgggttt aactacttca 1900081 tttttctcaa gtgtttcaca gaattcacta aaaccaatgg atctactggg agctgagtta 1900141 tttcccccgt atccttctgt agccaagctg caaaatgcta agaattttgg atcataaata 1900201 agatcgcttc agtttacatt taccactgat aatcacaatc ctctcaaagc tttttataat 1900261 tgtagcacct tttccatttt tacacatatt aaatatcgac aatcattcaa atgatttaat 1900321 aattgaatac aaaaaagaac ctgcattttg caagttcctt tcacgttgtc aatatattgt 1900381 gaatttttaa cgacaagggc atttatgtat agtatgatat ttcctgtaca gtaagttttg 1900441 ctcactcgag ggagtcttgc tcatccccta atgaaagggg tgatgctatg tcaacattcc 1900501 aggcattaat gctaatgctt gcaatcgggt cgtttataat cgccctattg acgtatatag 1900561 aaaaaataga cctcccttga gcctcagaac ctgaagggat aggcctacct agaaccacat 1900621 cgagcaagcc ctttgatggg caactttttg tacagagccg gggtgttggt agcacctcgg 1900681 tcttttttat tttatgcatt tctcattaaa gaaatgcact gtaatgtatt gtaaaactga 1900741 ttataacaca ttttccgtga aatgcattac aataaacctc aagagacttg gaaagctttt 1900801 ttattgtttc ttgtaacgtt ataatgatct aaaatagcgc acaagccttt atacatcttc 1900861 atcatttctt actcttctag ctcgtctttc aacattccaa ttcccaatct ttccccagac 1900921 attcttgtta gtccatttcc ctagcttagt tttatcaaac cattcctgaa acaaagatat 1900981 ttcatctttc ctttgcattg tatcttttaa aaggaaataa tgtattatcc aaaagatata 1901041 aagagctgaa caagaaagtc caaaaataag tttatttacc tctaaccaat ttcctaaaac 1901101 ttgttcgcct aaatatttat catatagaag gggtataaaa gcaaatgctg aagcaccgac 1901161 aaaaaaagct agagtttctt taaaccatct aacaaaaaca aaaacagcgc ttaaaatata 1901221 attcgttcta aaaagaactt tataccaatt ataattcttg tttagagtaa caaatatact 1901281 tctatattct ttattaactg cttgatctaa cattctcatt ttataaaata attttttcct 1901341 attctcgctg ttcttgttta aaatatactc tctgaaacaa tcttctgtat tcaaaatttg 1901401 atctatcaat aagatgtttc taagttttga tagcttcccc tttttcccac tatattcttc 1901461 gaaaaatttt tctataagga ccattttatg gttttcatct tcttcattct ttatttcttt 1901521 tagggaataa tacataggct ctaaaatttt ttctaatgtt tcacctgatt gagagtagaa 1901581 tcgttctata cttttttgtc tttgattgaa tagcaatgca actatacccg taattactgc 1901641 agtaagaata ccattttgtt gtatccaatt ccaaatatct aataactcca attaagcttc 1901701 tccccttctc tctgaattta cttttaatac gggctaaaat aaaaaaggtt tcatataaaa 1901761 cgggactaga aaacttctgt cactttaatt atttaatcca ataaaataag ctctcattgc 1901821 gagagcttat tttatttaga ttgaggatgt gcaactcaag ccttctattg cgctatagca 1901881 atacttttgc ttaatcgtcc cagtcttcat cctcatccca gtcatctttc gcttcctgaa 1901941 tcttattata aaaaaattca ataaagctgt ctgcaacagt atcttgataa ccaattaccc 1902001 tatcccattc aactacaggg cattctccgt ctttcatttt atttgtatct agacagtaag 1902061 caaagtaatc aacatcttca ataaccacaa gtccatcagt aaggccatag tgttctttat 1902121 attcattagt tctatttaca actgatgcat gatcaaagtt gtagcctaaa accaaaacgc 1902181 cgaataaacc accagcaccg tatttttcta aaaaccattt ataactgttg gggagatcgc 1902241 attggaggtt ttcttcaatg cgaccaatgt tttcatgact tgcaccttct gtaaatatag 1902301 cattttgttt attttcatta ataaagttct caaccttcga ataaatcata taaacacctc 1902361 aattctcatt ttcaaattgt ttcgctctcc atttccaata tctctttcta aagctctcgt 1902421 attgtgcttt taaaacctta tcatttctaa aactttcacc atcagactta agctgatgaa 1902481 tgacatcact atattttgta tgtaagctgt tcgggatttc aagcattggg ccaggttctt 1902541 cttgaatcaa gtgatgtaaa ttaatctgtg taccgtcttt tgcataaggg gcattcccgt 1902601 ttttcattag ctgaagattt gtaacaccga attctgtttt ttgattaata tcaatatctt 1902661 tcatagtata cactctacgg cttacatctt taactttccc cttcgccttt accttcccct 1902721 ctatttcata tgcatcatac ttttctttat ttagccaagg agggcttttc ttttggccag 1902781 taaacggttt tcttgttcca tccggtattt tcttcgcatt agtcaaaagt tcattcttaa 1902841 ggttttggct atcaaccaca ttgtatggca cgttatctgc tagagcaagc ttatacttag 1902901 ggttgtaagg cagcaaatct ggaatcttaa cgtccttgat tttcttacct gcttgacttg 1902961 ctttatttat taccttgccc gctgcatctg ctttgttaat ggctcctgca ccttttgtac 1903021 caacaacagc tacagccact gaaccaatag cataggtaac ccatcttgat ctagaatagg 1903081 catctccatt caccatatcc ttttgatatg actcttctat tgctgctgaa atggcatcgt 1903141 atgttttcac tggatgcata gctgcattac ccagtgctga gagtgtttct cctggatcgg 1903201 tgatgaagtc ccatatgccg gttacagtgt cttttcctac atcgtataaa ccaactccta 1903261 caccttttac gatatcccag gtgatttctc ctgctccttc tagctgcttc gcttgttcaa 1903321 tttgcactgc aagctgcact tgagttggct ccagattctc gtaccctact ttcttagcaa 1903381 tctctaaata ttcatcaggg tcagatacac cgtcattaag ttttttcttt aattccttga 1903441 tttcacgttc ctttgcttct tctttcttca cacttaagta agcttcagaa tgcttttcaa 1903501 tatcgccttt tttcttatgt atgtcacttt ctctgtacgc tttagcgtta tagtgaattg 1903561 gtgtagcgtt ttttcctttg cctgttgatt cctgcagctt tttaaagtct tgctgaataa 1903621 attgttcgtt tggttctgtt tcagcgtatt ctgtttttaa atcctcatca agcttgttta 1903681 gcttatcgat tgttttttca cgtttgtcat ctgcagaaga aagtttgtct ttgaagtctt 1903741 ctgttgagaa tatttcaagg ggaaggatat cattgatgtt gtttaatatg tctttcattg 1903801 cttttttctg ttcagacata atggattttg attttgcata agcgttagcc aactcgtgtt 1903861 ctagaaagga ttcttctatg taagcatcag acatcttcgc atcttcaagt gttgcagaca 1903921 tgctgcttaa gaaagcaatc ttcatatcga taagatcaat ccattggtct gttacgccga 1903981 catgaccatg ataaaatgct ttaatgttgt cagcaccctt gcctgaaaat tcactgtcat 1904041 ctaggttagc tacttcctta aacgcttttt tgagcttcac catttgcgac cttagttcct 1904101 tatactcttt ggttctttta tccgcttcaa agagtaatga atcagcctca aataccttca 1904161 tatcattctc cttcctagac tacttctatg taaattttac cacagtaatc taattgaata 1904221 acagaaaaag acagccaaaa tgactgtctt atacatcaca cactatcttg ttctataata 1904281 attttctgcg gtatagtagc gccaatccca aaaaggttcc ccattggcca atatataccg 1904341 gtctaaaaat ttttcaaagt ttaaatttaa tggattatat tctaaaccac tttcaaatat 1904401 atagagatag ttgggatcac cttggttcac tttatcttta tcgatcatta aatggcattc 1904461 ttccaataag tagccaattg gaataccatt gatatcttca aacaaatctt catattttaa 1904521 ctcctcttca atctcttcaa ggctaaatag ctgaagtcct ccacctatat tctccccatc 1904581 agaaagaatc tcaaaaattt tcgcaccgtt atgtagtgtc atgaacttct gataatcctg 1904641 tggaagggta agctggtgtt tagcctcaaa gctttgaatg tcattcaggg ttgctttgtc 1904701 ctgtgaaaaa gtaacaagga actccatgat atcaccttct gaacaaaaca attgaatggc 1904761 tcctttttcg tctaaaagac ttttcaagcc atttacagtc ttatgaacaa agttagtcac 1904821 atacatcacc cctttatttc cttttaacaa taacctttca aattccaaaa gatgtgaaca 1904881 gatcgtgata ggtgctcttt tcagtgaata taatgcaata aattctaaaa agaggtgcct 1904941 ccaaaaattg aattctctaa tgaatgatga catggtaaag atcattagaa atggccttag 1905001 cgcatcgcag catccaaagc acattcttgt tataggagct ggattgtccg ggcttgtatc 1905061 agcatctttg ttgaaaaatg ccggtcacag agtaacgatt ctcgaagcga gcggcagagc 1905121 gggcggccgt gtctgcactt tgagatctcc ctttagtgat gatttgtatt tcaacgctgg 1905181 cccgatgcgc ataccgaata accattcgtt aaccttagaa tatatcaaaa aattcaaatt 1905241 gccaacaaat gtatttatca acagaacccc gatggacatc atttatgcaa atggaatcaa 1905301 aacacgtctc caagtttttg aacgagctcc tggaatattg agatatccag ttgcaccaaa 1905361 tgaacaaggg aaaacgtctg aagagctgat gctttcttta ctgcagccta ttctaaattt 1905421 tatcaatcaa aatccagcaa gaaattggcg gattgtcgaa gaacaataca aaaatcattc 1905481 gttaagctct tttttaaaca cgtatttttc atatggcgcg atcgatatga tcggtgtact 1905541 tttggatatg gaagcgtata tggggatgtc ccttgttgaa gtattgcggg aatctatctt 1905601 tttttcatcc cccgctcact tctatgagat aactggcggt atggatctgc tgcctcacgc 1905661 gtttcttcct caattaaaaa caaacattct ataccatcaa aaaatgatga aaatgtctca 1905721 gggtgaaaat cgtgttacga tccattgtca gcatcaacaa acggcagaat tcacatcatt 1905781 cacagctgat ctcgctattg taaccattcc tttttcaaca ttgcgatttg taaaagtcga 1905841 accataccat tcattctctt actataaacg gagggccatc cgtgagctaa actatatcag 1905901 tgcaacaaaa atcggcatag agtttaaaag ccgattttgg gaaaaagccg gtcagcacgg 1905961 cggcaaatct attactgatc ttccgattcg tttttcatat tatccaagca gaaatattgg 1906021 agcaaatgga catgctgtca ttctggccag ctatacatgg gccgatgagg cactgatatg 1906081 ggacagtctt tcagaaggag agcgaatcca gtatacttta ctgaatttat ctgaaatcta 1906141 tggtgatatt gtgtggtctg aatttgtgtc tggcacttct tttagctgga gccagtaccc 1906201 gtattctgcg ggaggtttta cagctttcga accaggacaa gaattagagc tgtatcccta 1906261 tattcctgtc cctgagggca gagttcattt cgccggagaa cacgcctcac tcactcatgc 1906321 gtggatgcaa ggcgcgattg aatctggaat acgtgttgct tatgaggtca atcgcttacc 1906381 ttagatcatg ctcacatctt gttaaaactg gttgatataa aaagaagtga agaatttata 1906441 ctcctttgtt taaaagatta attcaaatat gggatgtctc aacattcggt tctttattat 1906501 ctttatacac gttttgaatg cggacctccc ttttcttcca taatcattaa taaataccca 1906561 accataggaa acgttttaat taaccatcgg gcgaactttc tttcactgta taacgattct 1906621 taatgttgct ttttatcctt tacttgtcct ctcttttttt cattgactta catttcttga 1906681 aaaccagtat aaatcctaaa ggaattttgt aacaaataca gaattggaaa gagaagcgcc 1906741 aaaagaaatg ctaactcctt atctcaaaga caaaactgcg cttatattaa aagaaagagg 1906801 tgtctttaga atggttcatt ttaaaaactg ccctgatcct tctctaaacg ccaattctca 1906861 gtctcacccc gaattttcat ccgaattaga acatattaag acaagaatgc aaaactttat 1906921 taagcactcg gttacagacc aaaatatcga agttactgac gcaagggtga cggccgaagg 1906981 agaggtcacc tctcttttaa aagaacgtct cgacaaggaa tattataggc ttttatctaa 1907041 aatcacccgg gaagtaaatg tggctgactt cggcgctgtt ccagatggaa gagacaatac 1907101 tgaagctttt cgaaaagcaa tcgggaatgg ccgagtcaaa gtacatgttc cagcgggaga 1907161 atacctcgtt caagggatta aacttccatc ttggacaaca attgttggac aaggtaaagg 1907221 gatcacagtg attaaattgc atgaagacac tccagcgcat gaatgggtga ttacaaatga 1907281 tgattatcaa aatggaaatc gcaatatttt tgtccaagga atgtcattag actggaatcc 1907341 aagtagacaa tgcggtgtga gaaatccagg gggacagttc tccagttgtt taacttttgc 1907401 taaggttgaa tatgggtgga tcaaagatgt ggaagcgatt aacgcaggtc ttcatggtat 1907461 tgatattaca tcgccaacgt atgaccattt gcctgatacc gattggacaa aagacggatc 1907521 aagatatatt tggatcgata actgtgtgac atatggttca ggagacgacg gcattaccac 1907581 ccattatagc gaatacatct ttatttcaaa ctgccattca ggaaatccgc ggggaacaga 1907641 atttgctgaa ggtgtttcaa actccaacgg aatagaaatt gacgacggct ctaggcatgt 1907701 gtggcttttg aataacttta caagcggcaa catccgcgga gttgaagtaa aagcccatga 1907761 actgtggcca gcctctcaaa acgtccatat cataggccat atttcttatc gcgatgttcg 1907821 tgcatttgat cttcgtcata ttggtcacca tcaaattaca gatcctgaaa gcacaacagc 1907881 atacgatgtc acactcattg attgttcagc agttgaacca gttttcaact cgctttacga 1907941 tgctgtgacc ccaagagcgc tggttatttc ggcatataaa aacgttaatg taagcggatt 1908001 cacagcgatt ggtgatccag actatgatta taaagaaaac cctgtcgtag ccttgcaata 1908061 tcgcagccaa aatataacca ttaatggtat taaaattcgc ggttttaaaa aagccggtgt 1908121 tgatattaat ttatcaggcg gatcaaataa aactgattat attaaaattt caaattttga 1908181 tatttataaa tctgctccaa aaggaatttc aatcggtgga ggcctctaca atgtcaatat 1908241 tctaaatgga acgatgatta ctgacaatgg gacagttgca attcagtccc ccaataatca 1908301 ggccacaatt ctcggtgtac aatcagaagg ttatagtgtg gcagcctcaa tcaaaggcca 1908361 aacataccaa caagttccaa tcaatttgaa aggaggcata cagcttgcaa cgacctctgg 1908421 ctttgccgtt aaccaaacaa gcgcagttat agcaggtacc ggcgacatta cggcccgcgg 1908481 agaaagaaat gcggtcatta gctcttctgg aggctccagt actgaaggct ctcgcgcatt 1908541 aatcgcttct tcaaataacg cacatattag aggaaaccaa gcgtcaagaa caatactgtc 1908601 ttctgaaaat attatacttg aggaaccata caccgtggca ggaggtcatc aatcaataaa 1908661 gtggcttctt gactctgttc ggggaaacgg gacgtttgcc ggtgcaatca gttcttcttt 1908721 aggtggatat ggagagtatt ttgagagttc aactggacag ttaatccata ctggtacaat 1908781 cgtgacttta agaggtgaaa aaattgtgcc cgcgaatgtt ggagattata tgcttggcgt 1908841 tatttcagaa acttcagctt tcatttcagg agcctccagt ttcgtctggc agggccgtta 1908901 tttgacaaat gagttcggcg gatttattta tgaaacggtg actgatgagg aaagcggtga 1908961 actcatacgt gttcccaaac aaaatccaga ctacgataca gcgctggagg caaattatca 1909021 ttcacgggca gcaagagacg aatggcacgt tgtagggttg gttggccaac attatgtgcg 1909081 tattgacgaa actgtcaatc aaggagatta tcttacggca cataatggaa taggaacaaa 1909141 agccactgaa ggaagctgga aagtaatgaa aataacctct gcttacacat cagaaaaagg 1909201 gtatggtatc gctctaaccg tcatcaaata gtggatacgc cgaccagttc aatatatgtt 1909261 tatccaaata attagatctc ttttctaggt tctttattcc ttgtatgtta ttatcaattt 1909321 tcaatatcta ccaaaatacc cctaatatac tatcgtaatt aacttatatt ataatcaaaa 1909381 aaattttgac agctgttcct tctcgttatt catgaaagtt gctattgaaa tgagtaaatg 1909441 gatatcatat tagacttcta tagcaaatac accatatata tcctttaagt atttacaaat 1909501 tgaaaatgtt tcatgaggct tattaaaagt attgttcttt tatcatctgt aagtcgatac 1909561 aaactgcatt aagatcacac ctaaatctca ctgagttttt tcttacaaat aaaatgaaaa 1909621 ccctttccat tctaaattca tttcaccgtt actaaaagta atccttgcat tccttcgccc 1909681 tccatgctat attcatatag cgatgagctg aattgtgtaa gccgatgtac atgcctttac 1909741 ggcacacacg aatgtggcgt gtggtgcatc gcctcaatac gcaaagacgt ttgccttagg 1909801 caaacgtctt tttttgcgtt atccgatttt tgtgccgttt gggacaggct gatccggctg 1909861 caaaaggacg acgtcgccct ggccgggtat gccgccgagg accaagactt ccgatttaaa 1909921 tccggcgatc cggcggggcg gaaagttcac gactgctatg acttgcttgt tgatgagacc 1909981 ttccggcttg taacgcttcg tgatttgtgc gctcgattgt tttatgccga tttcagtccc 1910041 aaaatctatc acaagcttga ttgccggtac tcttgcttca ggaaattctt ccgcttttac 1910101 aattgttccc gttctgatat ccaatttctc aaagtcatca ataactgcca tatcaataac 1910161 tcctttttct cctattgtaa aggagatata caatattctt ttaactaaag agccatcatt 1910221 ttttatccga atataaggtg tttcgataca ggcggggcgg cattcctgtg cttttcgtga 1910281 accatcttgt aaaagaagaa aggttttgaa agcccagcgc ctcgctcacg acggtaagag 1910341 tttcatttct ctccatcagc attctttttg cttcctcaag gcgaaggtcg gcaatatagt 1910401 tctgcgggga cttccctgtc tgttttttga accagcttga atagtaagct gggtgataat 1910461 gctcgatttc tgccagcttc ttaatcgtca gccgctcaaa taaatggctg tgaatgtatg 1910521 caattgaggc atagctatgg gattgaagct tttcttttat gtattgtact agcatatgaa 1910581 gcgagttggc tgttccggcc tttgcttcct ctgtcagcaa gtacctgatc gaagaccaga 1910641 aaggatcgag ggcagcttca attcctgatc ctgcacgata ctcatcaatt ttcattgcat 1910701 gaagcggaac atccagtaca agacattcat ttcttccgat agaacggaag cgatgctcgc 1910761 actgcggcgg aatatataaa aaatgatccg gatttaattt cacctggcgc ccctcagtct 1910821 caagatcaat actcccttca agcggaaaaa gaaattggct gtacgcgtgc ttatgtgaat 1910881 gatatagccg tgtgtatgtc cgtttttcgc aaattatctc ttgaagcgag tccattagca 1910941 aaccccttcc tttggtcatc ttttaatccg gtaatggtgt tccgatatag gcgaaaagcc 1911001 gatttttcca tataaagaaa ctgccgccag attttctttc atcacttgta aaaacatgcg 1911061 ttccgctccg ttgttttttg cccattcagt caacaccctg atcacttggg ttcctgcccc 1911121 ttttcctctg tgctcctcag ctacaacgat attactaagt ccgccataac catcaatgac 1911181 agaaaccgtg ccaagcgctg tcaggctttc tttgtcatac atcttgaaaa aagttttaca 1911241 cggcggcatg cgttcgaata tgtgtttgta acctttgtga cgctcgggtg aaaacccttc 1911301 taattgaata aattcatcta tccaaacaga tgatggctct tgttcccact tgtatgtaaa 1911361 tcggctgttg tcatttgttc ggctcataat tgaccggcac aacgctgtca tctggaagca 1911421 ctcgtctacc ttttcataac ggctgtctgc caatgcgtca tcaagccctt tcggtgatgc 1911481 gttgctaata tgaaaacaaa caggtaagcc taaactttga taaaaaagtt cggcctctag 1911541 ctgaaaatcc ccttcaggca tatccgcaga cgtccatacg ctatttgccc ttttggttac 1911601 gccaaaattc gctctgagaa gccatttccc tatgcttttt tgaaaataag ccggccatga 1911661 agctgccgct aatcgttcaa tcttgcgaat gtcatccatt gcataatgcc tctcccctat 1911721 gtatactccc ttgatattat acaatattca gaaatataag acatccattt atttgtttac 1911781 ataatatttt tattgtttat taataatcct gacaaaaatg tccgaattga aaatgacagg 1911841 ctttctaaaa tgtcctcctc acgttcaaat gcttcttttg cgattaaaac agtaaagcca 1911901 tgcagcagac ttctgagccc ccttgtcgca tgaatggcag tcttttcact tgcatagccg 1911961 ttttcaatga gcagcttcgt cacaagacag acaatttggt cagagacgat ttccgtccgt 1912021 ttgtcgtgaa ccttaagaag agccgcttca taatatccgg gattttcaat tgcaaaatca 1912081 acatatgcat gagctaaaga aagcatcgcg gaatctccct ttcgttcggt tacggagtcc 1912141 gccatttgat caaaaagctt tgtcagtcct ctgacagcaa gttctgctct gatcgcttgc 1912201 agcccgttga tatggttata caatgacggg gggcgaacat tcattttttt agaaagtgca 1912261 gcaagtgaga caccatttac cccttcctga tcggcaatct ctgctgcagc gtctacaatc 1912321 attttttggg tcaaacctat tctcggtgac atgctcatca tcctttcttt gctttttgga 1912381 tcgcctgtct catccgctct gaaggtgatc gcaggaattt tccatgtccg acagcgagac 1912441 aggaaggcgc cttatcggcg agcaattgtg cacttttgat ggcctcctcc ttattccatg 1912501 tggcgaaagc gggaaaagga aacgcccatt ttatctgacc tgatacagcg attcctccgc 1912561 gcaactgaaa cgcatctcct gctattaaag tgccgtttct tgtatcaaga aatgacatgc 1912621 tgcccggtgt atggcccggt gttggaatgg caagcagaga accaattgtt tcaccgcccg 1912681 tcagcagttg gtgaggcttt gtttgtatgt gtttcggaat acctcctttt ataggcgtct 1912741 gcggctcatc ttgccgcaaa gatgtgtcac cttggagcaa gaatgaatcc cgttccgaga 1912801 tcatgacctt tgcatgcgga aatgtttgtg ccaatgtatc cagtgatccg acatggtccc 1912861 catgtgcatg agtcagtaaa atatgctgaa gcggttttcc aagctgattc acagcttgaa 1912921 taatcccttt atagctgcct ggcagtgcgg catcaataag ggtgacttcg ttttcttcct 1912981 ctactaaata gcaattaacc ggaaacaatg ctggaaaaaa agtcagctgc caaaccgttt 1913041 ggtactgagt aattctcatc tttttattcc tcctaacaaa aactaatggt gttagtttta 1913101 ttattaacta acaccattag tttttcaaga gtttattatt tttttatcgc tacataaatg 1913161 ttaacttgtg ctcgctgtgg cactgcggca ttttgatcat acatctcaaa gtcacctgta 1913221 aacgtgcgca gatgccgctt atcccaagtc caaatttcct tccacgtttc aagcacaatc 1913281 tcttcaatag gaccgattct ggaagtgaaa acggcgtaag cggaagccgg caaatcaata 1913341 ttttcatatg gtcccggaag aatgtcgtcg tattcctgaa acgttccgac tgaaaacgta 1913401 taaaacccat tcgtctcttg ttcataattc gaatataagg caataatgct cttgtctttt 1913461 tcagcctgtg ataaaagagc gctcatatcc tgcttccata attgatccca cagtgccgga 1913521 atcctccttt cttccgtcat ttccagtgcg ttgcttgtcc gttgtgatag tccggcaaat 1913581 cgtttcaggt ctaagtgtgt tatatgtgaa aagcccatac gatctcctcc tttttttaag 1913641 attatagaca aagaaacctg acagcagtgt gtcaggtttc atatattttt tgcatgtgat 1913701 gaatggtttc ttttacttta tcccttatat gaagaggctg cagaacctca atatcctttc 1913761 cgaactggag caaaaaaccg atcagccatt gatcttctgg aagtgaaatc accgcctggc 1913821 agatttcatc ttcctcacaa cagtgaagga catcatatcc gaaccattca cctatacgct 1913881 gacgtgctga cggctgaaca agaataacca attcagttaa acggtccttt tggtaccaac 1913941 tcttatccca tggcaaagtg tccagctgaa tgtcttttct gataaatgtc tgatgtaaga 1914001 tggccagatc tttcatccgg ttcagtttaa aaaagcgaaa atcatttctt accaggcagt 1914061 aggcatataa ataccagtgc cccgccttgc aaaccaatgt ataaggttca gtttcccgaa 1914121 gtagtgtttc cccgcttgcg cttgtatatg taaaagatat cgttaacaac cgatcgatgg 1914181 cagcgctgat tttctcgcgc agcgtctttt gatcctcagt atggccccaa gccgtcatgt 1914241 caataaacca tttttctgtt tggtgcttaa atgcttgagt agattgctca ggtataaggt 1914301 gtttgatttt ttgataggct gtgctgtgag aaacgggttc atacatagat gaaacgcttt 1914361 gcaaagcgga agcaattgca aacaattcct cctccttcag ccactctctt tcaagccgat 1914421 acgtttccat gatgccaatt ccgcccccgg aaccctgtga ggtcacaatc ggaataccag 1914481 ccctattgat cgtctcaata tcacggtaaa ttgttctgac agatacttca aacagctcag 1914541 caagctctgc agcctgcact tgttttttgc tgatcaataa cacaaccatc gctaacaaac 1914601 gttccagttt cattctgcgc accttttctt cttgtatttt ccaacaaaac aatcataaca 1914661 ttttgataaa gcttgggcat atctattatg cggcggaata cacctcgcat atgctatgaa 1914721 aacaggggtt tccccttctt ttttgtgttc agtatttatt tcagctacta tttccgaccg 1914781 gataagcata cacttctcaa cggaggggat ttcacatcat gcatcttaca cttcagagcg 1914841 tttatcctgc cataatcatc atcttttttc tgtataaaaa aattaaaagg tccatcggat 1914901 accagccgct gaagccccgc tggctgttca cccgtatcat tcttttctcg ctgtttgctt 1914961 ttggactttc aatcttcagc gccattcacc cttttttata tggatatctc attttgggca 1915021 ttcttggcgg atggctcctt gtctttttcg ctaagaaaaa catctctttt gaaaaacgca 1915081 gaggaaagat ctattttcgg actcatattt gggtagaggt gattctctta actttatttc 1915141 tatcaagatt tctgtatcga gtgacggagc tttatcttac ctcacctgat ctaaaccgcc 1915201 ttggatcata cagtcagtca atcggaacgg accctctgac aattggcgtc tgttttctga 1915261 tagccgttta ttatatcggt ttttcttctt ttatcatcaa gctcagcaga aacgaacttg 1915321 aacagcacga atacaataaa gaaaaagaca tccttgcccg ctaacagcga gttaagcaag 1915381 gatgtctttt tcaatcatgc tgtgtatgat ggatcatttg ctgaagaaca tctaaaacat 1915441 gttcatcctc cggagagtaa taaatcgatg ttccttctct gcgcgatttg acaagccgga 1915501 gattttttaa aaatctaagc tggtgggaca cagtggattg cagtaaattc agcttttctg 1915561 caattccgtt tactgcatgc tcaccttggg acaataaatg gagaattctg attcgggtag 1915621 gatctgaaag cgctttgaat gtttgcgcga ctagaaacag cgtctcctcg tccagatcag 1915681 cagccgattg ttccgtttct ctaaattcag tcatatgtat cacctttctt tattcatagt 1915741 tttatcttat aacaaatgcg cttgagtgca aaccagcctg cttgtattcc atttcaatct 1915801 catagtttaa atttatgttt caaatcaggt ttttacttgg tctgatatac cctcttatgt 1915861 cataataaaa aaggtcatac tgctccaaac attgagggtg aaacacagtg aagaaaaaga 1915921 gaaaaggctg tttcgctgct gcgggtttta tgatgatttt tgtctttgtc atcgcctctt 1915981 ttttattggt cctgcttttt ttcaaccggg atttaatcaa aaaacttccg atcgatacga 1916041 aaacgattgt tttggaacgt ttaaccgatt acaaaccctt ggtggaagaa gagcttgaaa 1916101 gccaaggact ctctaattat acatcactca tattaggcat gatgtatcag gagtcaaaag 1916161 gaaaaggcaa tgatcccatg cagtcctctg aatctctggg gttaaaacgc aatgagataa 1916221 cagaccctca actcagtgtt aaacaaggca tcaagcaatt taccctcatg tacaagaccg 1916281 gtaaggaaaa aggcgtggat ttggatacca ttattcaaag ctacaacatg ggggcaggtt 1916341 acattgattt tgtagctgaa catggaggaa cgcatactga ggaattggca aaacaatact 1916401 ccgagcagca agtcaaaaaa aatcctgatc tgtatacttg cgggggaaat gcgaaaaatt 1916461 tccgctatcc gtattgctac ggtgattata cgtatgcaga aaaagtaaaa gaaaaaacaa 1916521 aaactgttga agaatctttg caggttgcaa cacttgaaac catggaatcc aaggctcatg 1916581 aataagagtc tatcaattta ctgacaaaag cccaaaaatg aatttgggct tttgccatgt 1916641 ttacacgtaa aaaaagccat actgagtatg gcttttaata atacggtgaa atcatcaaat 1916701 atacaataac gcctgtaagg cttacataca gccatagagg cattgtccat ctcgcaattt 1916761 ttttatggcg ctccacctgc atgctgaagc ctctgatcag cgtaaacagc gcaagcggca 1916821 caataattgc agaaaggcag atatgtgtaa ttaaaataaa gaaataaatc gggcgcataa 1916881 taccttctcc gccatagagc gtgttttccg caatcgagtg gtacgtcaca tagcaaatca 1916941 aaaatagtaa tgttgttgtg aacgcagcca aaataaagcg tttgtgagct ttgatatttt 1917001 tctgtttaat cataatcagc gcggccaata agaagataaa cgtaaagcta ttgaatatcg 1917061 cattcagcat tggcaaaatg tgaatattcg catggctgaa ctgatctaat ttaggcataa 1917121 aaaacagcac tgcgattaaa ccgttaatca gaactgtcag cgtaaggaca atccccgtgt 1917181 aatttttcgg tttattttct gtttggttca tttggtgacc tctcctaatt tgtactggct 1917241 atccaaatcg tatgcaaatt caaagaagat gtcaacggtt tcgattgctt cgtcagaaat 1917301 tagacacact tcaaaggccg gaggctatta gccccggcct gttaggttta cgcctctttt 1917361 atcaaatgtt caatgacctt atgttcattt tcattcagca ggttcttttg aattttcgaa 1917421 tgaatgggtt tattcatatg ctgatccaag atatcggccg tttctttatc cccggcaata 1917481 accattcgtt cccatctttt cgcggcagct ttttgatcaa ggctggcagc cagccgctta 1917541 tacagtctcg attggttctc tgttacatgt tccctcatcc ggttctcttc aaatggtggc 1917601 gctttgtcta cagcggaatg gctattcttc caagactcat tgatcatatc atactcataa 1917661 cgctccaccg cctcaatttt tcctaaaaca gtttcaataa ttttcacttc atgctgctga 1917721 gttaaaataa acgccgtact tgggtatgtc tggcgcaaac cctttagctg atccaggaca 1917781 gctgtttctt cccagtaaaa tcttgtatct acagggactt gaagcttaat aggttcccat 1917841 atgccgctgt cggaaacaaa aaacacgaga ctgcggggca tgtcttttcc cattgcattc 1917901 aagtattgat tcattttagc cctgattcca tccagacact tttcctcctc tggatcacta 1917961 gctgccaaat actcttttaa tcggctgaat cctgacttta gggcaatctt ccattctccc 1918021 ccctgctgct ctggatctct catgtctgta ttgagataca gagagagaat tttatccggc 1918081 ggttccaatt ggacatactg taatttgtta atcaatgaat caatcgccat tccgattcct 1918141 cctttttcac aggttagttt tctttttcct ctcttaaaaa cgatcaaacc tgactttccg 1918201 ctaatttcta gtaataatgg aattgttgtt tacaatacgc ctctcttcta atacaattgg 1918261 taactgtgtt tctaagctgt tttttgaaag gagtttgatc ttgtttactg ttaaagaaaa 1918321 aaatcgtcaa gagcttgagg aagaactaaa tgatttagaa tttcaaattt atcgcatgca 1918381 ggagaatatg aaggatttat ctaaagatgc caaagtgctt ggtattgatc aatcgaaaca 1918441 tgatgagtgg atgattgttt cctcgattga tgatggccaa acatgcaaaa ttatgctaac 1918501 tgattgtaaa acggcatacc gaggaaaagg ctgtttttca cttgtagcgt cttacaagga 1918561 cgatgccatt catatagggg atataaaagg ccctccgaat cacgggtttg gctccatttg 1918621 catgaaatat ttaaaagata ttgcaagaga ccataatata ccgaaagtca ccggagacat 1918681 cgccaaacgg gattggaatc atgtagaccg gctgattcac ttttatgaaa aacatcactt 1918741 caaagtatgt atcgatcatg atacccaatc cggcagcatt aagtgggttg atttgtaaaa 1918801 aagtctggaa gaaagagcca agatatgctg taatggtata aaaccattga tggagggttc 1918861 tatgtacgcc tcaaaactga aaaagggaga cgaaatccgg atcgtgtctc ccgcgaccag 1918921 catgtctata ttatcaaatg aagcaaaaat ccaagcaaaa acggcgttag aacgcttagg 1918981 ttatcgggta accatcgctg aacacgcaaa tgaatgtaac gaatttgatt catcctctat 1919041 cgagtcaaga gtccatgatc tgcacgctgc cttttttgat ccaggcgtca aagcgatttt 1919101 aacgacactc ggagggttta attcaaatca gctgctgcgt tatcttgatt acgagaaaat 1919161 caaacgacat ccaaaaattc tgtgcggtta ttccgatata accgctcttt gcaacgctat 1919221 ttatcaaaaa acgggtcttg ttacgtattc aggtccccac ttctcaacat ttgcaatgaa 1919281 aaaaggactc gattatacag aggagtattt tctttcttgc tgcgcttcag acgatccgtt 1919341 tgaaattcac ccctcaagtg agtggagcga tgatcgctgg tttttggatc aagaaaacag 1919401 gcgtttttat cctaataacg gccctgttgt aatccaagaa ggttatgcgg aaggtacttt 1919461 aattggcgga aacttatgca cgcttaattt gctgcaggga acggagtatt ttcccgaaac 1919521 agaacatact attttattga ttgaagatga ttatatgtca gacatccata tgtttgaccg 1919581 cgatctgcaa tcactcatcc acctccccgc tttttcacat gtaaaggcga ttttgatcgg 1919641 cagatttcag aaagcatcaa acgtatcaat agatcttgta aaagccatga tcgaaacaaa 1919701 aaaagaatta tccggcatcc cgatcatcgc aaatataaat gccggacata cctcgccaat 1919761 tgccacgttc cctataggag gaacatgcag gattgaagct atttcgggta catcacgaat 1919821 atggattgat aaacattaat cagcttgtaa atttttttac aagctttttt agcgcaatcg 1919881 gctatgcatg ccgcacgaga catgacaaat gtcatatagg aggcatgatg tgtgctacta 1919941 caaaagactt ctctcattag cgtatactga accgagacac acaatgagag gatacttact 1920001 atgactgaac aaaccattgc acataaacaa aaacagctga caaagcaagt cgctgcattt 1920061 gctcagcctg aaacaaaaaa cagcctgatt cagcttttaa acacgtttat cccattcttc 1920121 ggcctatggt ttcttgctta tctcagcctc gatgtctcct atcttcttac gttagcatta 1920181 acggtgattg ccgcaggttt tctgacaaga atttttatca tcttccatga ctgctgccat 1920241 caatcttttt tcaaacaaaa acgctataac cacattctcg gttttctgac aggtgtcctg 1920301 actttattcc cgtatcttca atggcagcac agccattcga ttcatcatgc aactagcagc 1920361 aatctggata aacgcggaac aggagacatc tggatgttaa cagtaaacga atataaagct 1920421 gcatccagac gaacaaagct tgcatacaga ctttatagaa acccgtttat catgtttatt 1920481 ctcggaccga tttatgtttt tctgatcacg aaccgtttta acaaaaaagg cgcaagacgc 1920541 aaggaacgtg taaacacata ccttacgaat ctggcaattg tcgcgttggc tgccgcttgc 1920601 tgtctgatct ttggctggca atcgttttta ctggtgcaag gcccgatatt tctgatttca 1920661 ggttcaatcg gtgtttggct gttttatgtg cagcatacct ttgaagattc ttattttgaa 1920721 gcggatgaaa actggagcta cgttcaggct gctgttgaag gcagctcatt ttataaactc 1920781 ccgaaactgc ttcaatggct aacaggcaat attggttacc accacgttca tcatttgagt 1920841 ccaaaggtgc ctaactataa gcttgaagtt gctcatgaac atcacgaacc attaaaaaac 1920901 gtaccgacaa tcaccttaaa aacaagcctg caatcacttg cgttccgtct atgggatgaa 1920961 gataacaaac agtttgtgtc atttcgggct ataaaacata tacctgtaag ccttccgcct 1921021 gattcaccag aaaaacagaa gctgcggaag aatgcctgat gataaaggag gtcttctaat 1921081 atactagaag gcttcctttt tattgttgga gggtgcattc tggctttcac aatgataaag 1921141 ttacaagtaa gatgaaaagc tgaaaatgag gtaagatcat gattaaaaat cattttacat 1921201 ttcaaaaact aaacgggatt acgccctata tatggacgat atttttcatc ctccccttct 1921261 actttatatg gaaatcatca tctacatttg ttattattgt cggcatcatt ttgacgcttt 1921321 tatttttttc ggtatatcga tttgcttttg tctcaaaagg ctggaccatt tatttgtggg 1921381 gatttttatt aattggcatt tcaaccgcct ccattactct gttcagttat atttattttg 1921441 ctttctttat tgcttatttt attggaaaca ttaaggaacg cgtccctttt catattttat 1921501 attatgtcca tttaataagc gcggccgtcg cagccaattt cagtctcgta ttaaaaaagg 1921561 aattctttct gacacaaatt ccttttgtcg ttattaccct catcagcgca attttattgc 1921621 ccttcagtat aaaaagccgc aaggagcgcg aacgacttga agaaaagctc gaggatgcaa 1921681 atgaacggat tgcagaactg gtaaaattag aagaacgtca gcgaattgcc cgcgatctcc 1921741 atgatacgct tgggcaaaag ctttctctta ttggtttaaa aagcgactta gcaagaaaat 1921801 tgatatacaa agatcccgaa caagcagctc gtgaactgaa aagtgttcag caaacagcgc 1921861 gaacttcttt aaatgaagta agaaaaatcg tttcctctat gaagggcatc cggctcaagg 1921921 atgaattgat caacatcaaa caaattctcg aagcagctga cattatgttt atctatgaag 1921981 aagagaaatg gcccgagaat atctcattgc tgaatgaaaa cattttgagc atgtgcttaa 1922041 aggaagctgt cacaaatgtc gtcaaacaca gccaggctaa aacttgccga gttgacattc 1922101 agcagctctg gaaggaagtt gtgattacag tgtctgacga tggaacattc aaaggagaag 1922161 aaaattcctt ttcaaaagga catggcttac tcgggatgag agaacggctt gagtttgcaa 1922221 acggaagcct tcacatcgat accgaaaacg ggaccaagct taccatggca attcctaata 1922281 attcaaaata aacataaagg atggcttata tgattagtat atttattgca gaagatcagc 1922341 aaatgctgct gggcgcttta ggatcacttc taaacctcga agacgatatg gaagtcgtag 1922401 gcaaaggtac aaccggccaa gatgctgttg attttgtcaa aaaacgccag cctgatgtat 1922461 gtattatgga cattgaaatg cccggaaaaa cagggcttga agctgctgag gagctaaaag 1922521 atacaggctg caaaattatc atcttaacca ccttcgccag acccggttac tttcagagag 1922581 ctattaaagc tggcgttaaa ggctatttgt taaaagacag tccgagtgaa gagctggcca 1922641 acgccatccg tagcgtcatg aacggaaaac gcatctatgc acctgaactg atggaggact 1922701 tatacagcga agctaaccct cttacagata gagaaaaaga agtgctcgaa cttgtggctg 1922761 acggtaaaaa cacaaaagaa atcgctcagg aactcagcat caaaagcggg acggtgcgga 1922821 attatatctc aatgattcta gaaaagcttg aagtgaaaaa tcgaattgaa gccattaccc 1922881 ggtcaaaaga aaaaggctgg tttaaataaa aaaggatctt ggcatctgcc aggatccttt 1922941 ttgttaacct gaaattcccg tttgagaacc tcgtcgcaac cagaattaaa ttgatccata 1923001 tcctcgctcc tacgcccgct gaacgattgt ttggttaaca gcccaataaa agactggatt 1923061 gaatgatatc cctgttaaaa tggtcggcca ttgcacatca gcagaatttc tgatattgat 1923121 tatattgtat tttcagtatg acaaagttgt gccacttcgc tcccgaagct gccatgccca 1923181 actgcaagag cctaatatca caataaaaaa ccgtctgaaa tcaatccgat tccgtaaatg 1923241 gtatctgcta catccaactg cttattatct gccaaaaaca ccagctcgtt tcgctgatca 1923301 aagatagtaa caaccagcta taaatgtcat gatgccgaat gtctctgtaa tgtggaatca 1923361 atcttttaac ccgagagccc ctgaatcgca cataaagaaa aacgggacca ctttctttta 1923421 tcagcatatg atataaacag ctctaagcag aacaaaaaaa gacacaagcc aaaagcttat 1923481 gtcttttatc acaatctata ttattagttt aagactttaa cacttacagt tttgacgccc 1923541 caattagaag catcactttt acttggtaca aatacgtcga ttttatttcc tttaatagcg 1923601 ccgccagtgt ctgctgctgt tgcttccccg tagccttcaa catagacttt agaacctagc 1923661 ggaattacat taggatcaac cgcaataact ttcgcgttcg ggttcttatt taagtcaatg 1923721 cctgtagctg taacgccgga aatgccgccg tcgttagcag tgtaagcagt agcagtaact 1923781 gttagttctt ttgaagcttc ttgattattt gtatttgatt gaacagcctt ctcctctgtg 1923841 ttaacagaag tttctgcctc agcctttgtt tcttgtttag gttgctgttg tacagcttct 1923901 tgtttaggtt gctctttttg cacagcctct tgttttggcg cagcttgagg tgcgtttgtt 1923961 tgcgcattct cagtagctgt gtttgctgct gttgcctgac cttttactga aagagttgat 1924021 ccagcataga tcatgtcaga gcttaagtta ttccaaactt tcaggttgtt gactgtcgtg 1924081 ccgaattttt gagcaatctt agaaagcgta tctcccgctt taattgtata ttgcccagtc 1924141 gtggttgttt cttctgaaga aatggtcagt ttttctcctg caatgatttt atcagaagtt 1924201 aacttgttcc attcttttaa gtcctttagg ttcactccat ttttctgaga gattccccag 1924261 agcgtatcac ccttttgcac cgtaatttct tttgcagaag cgtgagctcc gaatgcagtt 1924321 gttgaaagtg cagcaactgc cacaaaggac ataatcgtct tcttcataag taaatcctcc 1924381 cttgttagct ttttattggc ggctaacagg tgatatcgta acacacgtaa atgtcaaatc 1924441 aataacaaaa agatatgatt tagattacag ttcctttaca tgaaggattt ctctctgatg 1924501 gaaagacttg ctgaaccctt gatataatag gcttcgcagg tctttttatt ttgaggcgaa 1924561 acagagaaaa taaaatgtgt tttttataga aaaaaagatt gtttttctgt ttttttagtc 1924621 tgtcatcctt gcataagcct gtatttcttg taaaaaaagc cggccgtatt ttgctctttt 1924681 ttgttctccg actcctttta tagacaaaag ttcatcatca tttacgggct gttttcctga 1924741 catttctttt aacgtttggt cagagaaaac aacaaatggc ggaacaccct gctcagccgc 1924801 aatttctttc cgaaccatgc gcaatcgttc aaatagctcg tcattttcag taatcgctgc 1924861 cgcttttaac gcttcttttc tcgctactga taattctcct ttcagcacat tccttccttt 1924921 actgctgaca aaaagagtcg gaaacgttcc gtctgacatc ctgatgaagt cgtcagaaat 1924981 aagaaattcg ataaaatcac tgatttcgcc aacggattgg tgttttaata tcccgtatgt 1925041 tgaaaggtcg gaaaagccgt tttcaagaac ttttttattt ttggagccgg caagcacctg 1925101 ggcaaccatc gtcttgccaa accgttcttt catgcgaatg atacaagata agaccatttg 1925161 cgcctcccgc gtcacgtcat gggccgctct tgtatcggta cagtttccgc actgtccgca 1925221 cgcatcaggc tccttttctc cgaaatacat aaggataaaa cgctgcagac aatcttccgt 1925281 atgacagtag tcgaccattt gtctcagctt ttttaaatcc tgcttttgtt tctcttcatg 1925341 ttctgattgc tcaattaaga agcgctgcac cataatatcc tgcggtgaaa acaggagaac 1925401 acattcactg gcaagaccgt cccgtccagc tcgtcctgcc tcttgataat agctttccat 1925461 atctttcggg atttgtgcat gcagaacaaa tctgatattt gatttatcaa tacccattcc 1925521 aaaagcagag gttgccacca tcacttgaag ctcatcatta agaaatcttt cctgctgctc 1925581 ttttctcaca tcatcagcca aacctccatg ataccggcct gccctgacct gatttcgttt 1925641 caatctctca tatatccgat cagcttcttt tctggtcgct gtatagacaa ttcctgcttc 1925701 atgcctgttg ttttgcacat attcgtctat aaaccgatct ttattttctc cttttactac 1925761 tttaaaggtt aaattctctc gggaaaatcc ggtatatacc gtgttttctt tttgaatatg 1925821 cagctgtttg caaatatcat catgaacctc gggtgtggct gttgctgtta acgccatgat 1925881 gacaggcttg tcgtgtaatt cacggaacaa gatttcaata ttcctgtagc ttggcctgaa 1925941 atcatggccc cattgagaaa tacaatgcgc ctcgtctatt gcgaccaaag gaacatctat 1926001 gccctgcaaa atccggataa actctatgga cgttagtcgc tctggtgtaa tgtaaaaaag 1926061 cttataagcc ccttctttga gtccgttcag cctctcatat atttcctgat tggattgtgt 1926121 gctgttaatg taggcggcgt taatccccgc ttcttctaac gcatcaactt gatccttcat 1926181 caaggaaatc aacggtgaaa tgacgatcgt cgtcccttca aacattaatg ccggaatctg 1926241 atagcaaatc gatttgccgc ctcccgtcgg cataatgcag gccgtatttt gcctcgcttc 1926301 cgtcaccaag cggatcgctt catcttggcc gctccgaaac ttctcataac caaaataatg 1926361 agccagaagg gattgggctc tatgtaacat aacgtgtaaa cctcgctttt ccttgaattt 1926421 ctcccatcat atcataaaaa agcggccttc atttctttca cacaaaaatg gaatattcac 1926481 tataccaaac ctttttagat aaaataaaaa gccatttccg aaaaggaaat ggctttcgct 1926541 acgtcttgcc gtatgcaagt aagaaagttt taaaccacca ctcctcaaag tgggtgtttg 1926601 cagaaacgtt cctgtcgtcc tctgcaatgg aggcatgaca ttccggcttc gatataaaac 1926661 tccctattac agcttaaagg ttaaaactta attaacaata cgcacaaagt agcttcttta 1926721 atatagtaca ccatcaggcg cttttaatca agaggtcaga acaattgttt agaaaaactt 1926781 tttccagtga ataaaactgt tttttctcca aaatacctga caattcgaca aacaaaaaat 1926841 atattacaat aaaaaaaata gcctttattg ctaaaagcga atgattattt tcttctatat 1926901 taatgtgtat atacaaaaag actcctattt gtaacgatag gagtcttggc tttattagaa 1926961 ttttgcagca agatcttttg cttcttgtaa acctttttca acgatttctt gcgcttgatc 1927021 aggtgctgcg ttatgtcctt cgatgacaac tgtgtgcaag tcttgaacac cccagaaacc 1927081 aagaactgtt ttcatgaagt ttaatgacat ttcaagtgca gccattggtc cttctgagta 1927141 gacaccgccg cgagcgttaa gaagcgcaac ttttttgccg cccattaaac cgactggtcc 1927201 ttcttgtgtg tatttgaatg taacgcctgc gcgagacaga taatcaacat aagtatgaag 1927261 cactgctggc actgtgaagt tccaaagcgg gaatgcgaaa acaactttgt cagcttttac 1927321 aaactggttc agatatttgt cagcaattgc tgcttgtttt ttctcatctt ctgtcatttc 1927381 cattccttga cctgctttaa atgttccgtt aatcatatct ctgccaaggt aaggaaggtt 1927441 ttccttatga agatctaatt caaccacttc atcattaggg ttgttttctt tataagcagc 1927501 taagaaagct tcgtaaagtt tagttgaaac gccttcttca gctgtacggt cgcttgattt 1927561 tacaaataaa actgtagaca tttgtattcc tcccggtaaa ctttttatat ttacttacaa 1927621 atagtatgtt actttctttt ttacgtaaag tcaatcactt tattttgaat atgagatttt 1927681 ttttcaaaaa aaagcaagta catctaatat cggtgtactt gcttggcatt tttacttcga 1927741 atcttgttca cgatccaaga tttcatacgt ctgcgagctt ttttgatcaa ttgtttcttt 1927801 gttggataag tcttttacct gttcatgaaa ctctctttca taagaaggag catctgtctc 1927861 cagatcatcc tccacatcag cttgggcctc aactgtcatt cttgcataag gaacagcttc 1927921 aagtctttcg taaggaatct cttggccggt tttttcacac acgccataag ttccgtcttt 1927981 catcttttgt aatgcacggt tgacctcctc taacagctcc cggtcaatct ctttcactgt 1928041 ttggtctgtc atccggtctg tgacgagcgt cccgtggtct gccatatggt tgtcaacccc 1928101 attggaaagc tcccccactt cttccgtcat tgattctgtt tcctttttct cgccagacaa 1928161 ttctttttgc atatcgagca atttatgata gagatgctgt gtttgttctt ttgtcagtgc 1928221 catgtatatc ctctcctttc tatcctgttt cccgttttgc cttctgtcaa acatggaaac 1928281 atcgatggaa agatgagcta ctgccttttt gaacggatcg tgaccgctgg cgtcgatggt 1928341 gcttcgggtt ttcgttggca ctttttgtcc ttctcttctg gcggtatata ataggttgcg 1928401 cctatattta atctgccgct cagttcatca atggtcagct cgccgaattc aagatgatag 1928461 tcaacttttt cgacattcag cgtttcaata tgtatatagg tttcttcaga ctcttgtttg 1928521 ctgctttgtt tttgtttctc aatcactgag agtctttctt cacattcacg cagtttgtca 1928581 agttctggtt tcaagcaatg cctgatcagc gaccggaaca tttttttcat gacatcacga 1928641 ccctttgcat actcctcttt cgtctacata tataatgagg tatatcccat agaaaggaga 1928701 ggttttcatg cttccgacta acatcaatat ttctcatctc aagactaact cgataggcac 1928761 cggctcatcc cttacctttg gttctgcgga gttaaggaac aggtgctctg ctatcaaaag 1928821 aaataacggt tttggggaac aaaatgcaga tggtattgtt atggtcattc cgattgaatc 1928881 aattgatgac cgtgatgtgt cagatgcact cagtatgaaa atcaatcatc aataacaatg 1928941 gttttcgctt gaccttcgtc tttttgaata gtgatgtata ggattccgtc tttaaaaatg 1929001 gcattcatct ttccatgaag atgatcggaa agcggaattt tcttttcaaa acttccgtat 1929061 ttcccttctt tttggcgaaa gtcctgttca ttaaaatagg aaaagcgctg ccccttcacc 1929121 actaaataat ctccgtacga taatatgtga acgtcttgtt tacggtagcc tggaagataa 1929181 attaaaaact gcacttccgc aacggtatct acaatatcca tgctcggaaa tgaagcatct 1929241 cctttccctc gctgatcttg ctgcgcaaac ggaaacggag attggccatt tgtcataaaa 1929301 ggggtttttt ggtcttcatc aaatacctgt ttccaaaagt caccgccgta catctgctgt 1929361 gcgaattcca tccactgctt catcttttcg aaatccattt gaagccccct gtcttaacat 1929421 actttataac cgccagcata caactataga aaggaggttt gcctgtggtt caaccaactc 1929481 cgtatatcaa tattaatatt ttcatgctga aaattaattc ctttgaaaat gcttcagcgg 1929541 ttaacgtagg acaaaattta ttggcagaat ggcaaaattc agataaaaaa aatcaaggct 1929601 acggacagaa ttttggagat gcgagcggat ttatgggcac gagaagccat gtggatgaca 1929661 gagaccaaat tgattctccg gcctcttttg aaagtgaagc ggttaactcc tcaatcaaaa 1929721 ggaagtgatg agatgttctt ttcaccctcc gtcgtaaatg tcggcggatt taaaatcaat 1929781 acgatggatc gaggttcctc tttaacactc ggtccgtatc agcaggtcga ttacttttta 1929841 tcagctaaaa taaatcaagg gtttggagaa gaaaatggcg actttactcc tcttgtcgtg 1929901 ccgatttcaa atgtattaga tgcagatctt gttgattcga actcagcgaa aaacagtgtg 1929961 gtgtaataag aacagggcgc acatgccctg ttcttgtttt tatatataaa aaaagcctaa 1930021 ccattttttg aacggctggc tcatcaaata ttcagctgca caaatgcttt gtcagcaccg 1930081 cctgaacctc gcttaaatcg gtgtctttcg caaattctaa ttcgaaagtt ttgcttcttg 1930141 tcatcaataa aagcccagtg tccggatcaa acattcccgc ttcttggatg gcaaagcttt 1930201 caattgtttt atatggaaga aatacacgaa ccttcttttt agaaaacatt ttattgtcaa 1930261 agaaaatgat ccgcttattt gtaaagcaaa tttggtccac tcggagctta taaatcgatt 1930321 caattctttc cccttcaacg agcaaagcct caagcttctt tgcgtccgtt gatctgctaa 1930381 cagaaaaaat acccaatgaa gaacccctct ttctgcattt atctatttgt tttatcattc 1930441 actacataaa aataagtcct ttatccctat ataagaatac gacatagaag acatttaaac 1930501 cattacgaac agattacatt tttcaaattt ttgatttgtt ttttggcttt taagctgttg 1930561 tcatcaagta atacgcacat atagagaaaa aagtttcaat attcagcaat gtttttataa 1930621 aaaagtggtt tttaatgatt tttttaattt tgttttatat ttcctgtttt aaccacaaaa 1930681 aaaccgcagc tgagctgcgg ttttatgtat cgactgcttt taacaaaatc tgtttgatgc 1930741 ttcaaggaag cattacatct cttcgaagta ttctttataa tagccgccga ctttattcgt 1930801 attgtcgacc acaaagagaa actcctctgt ttcatttttt acttcatatt cttttcccgg 1930861 cgttaaaacg cggtttacga tatatttttt tgcgtttgtc tgcacacact ttactttttt 1930921 aatggtttct ttttcaagcc aatttttatg aatcatgatg aaatctcctt ttcttatcta 1930981 taagcttatt gtagcttttt tcttttgtaa attgcaatat cggttattca ttgattttgc 1931041 cttgatttct attatagaat gtttgtatac gcttacgttt gaagcaacta tcacagctta 1931101 tttctgctat tcaatccagg aatcaatgtg ctatcaccaa gaatctcaga acagaccata 1931161 aaaaatgact ggaggtttgt tacggatgag ttctttaacg atgcaagtga cgaaaaggct 1931221 ggagacattt ttacagggaa caaagaagct ttatattgac ggaaagtttg ttccgagtgc 1931281 ctcaggggca acctttgaca ctccaaaccc ggcgaccggc gaaaccttga tgacgctgta 1931341 tgaagcccag gctgcggatg tggacaaagc tgttaaagct gcccggaaag cctttgacca 1931401 aggtgaatgg agaacaatgt ctccagcttc gagaagcaga ctgatgtata agctggcaga 1931461 cttaatggaa gagcataaaa ctgagcttgc tcagcttgaa acacttgata atgggaaacc 1931521 gatcaatgaa acgactaatg gagatattcc gctggctatt gagcatatgc gctattacgc 1931581 cggctggtgt acaaaaataa caggacagac gattccggtt tccggcgctt attttaatta 1931641 tacgcgtcat gagcctgtcg gtgtcgtcgg ccagatcatt ccatggaatt tcccgctcct 1931701 gatggcgatg tggaaaatgg gcgcggcact tgcaacaggc tgtacaatcg tcctcaaacc 1931761 ggctgaacaa acaccgcttt cagctcttta tttggcagaa ttaattgacc aagccggttt 1931821 ccctgccggt gtaatcaaca tcatcccagg attcggtgaa gatgcgggag aagcgctgac 1931881 gaaccacgaa gcggttgata aaattgcctt taccggttcc actgaaatcg gaaagaaaat 1931941 catgtccacc gcagcgaaaa gcattaagcg tgtgacattg gagctgggcg gaaaatcgcc 1932001 taatattctt ctgccggatg cgaatttaaa aaaagccatc ccgggcgctt taaacggtgt 1932061 gatgtttaac cagggccaag tctgctgtgc gggctcacgt gtcttcattc ataaagacca 1932121 atatgatgaa gttgttgatg aaatggcatc ctatgctgag tcactccgcc aaggagcggg 1932181 acttcataaa gatactcaaa tcgggcctct cgtaagcaag gaacagcatg agcgcgttct 1932241 ttcctatatt caaaaaggaa aagatgaagg agcaaaagca gtgaccggcg gaagctgtcc 1932301 ttttgaagca ggatattttg tcgcaccgac tgtgtttgcg aatgttgaag acgaaatgac 1932361 catcgcaaaa gaagaaattt tcggacccgt gctgactgca attccgtacg aaacagtcga 1932421 tgaagttatt gaacgggcaa accattcaga atatgggctt gcagccggac tatggacaga 1932481 gaacgtcaag caggctcact atatcgcgga ccgacttcaa gccggaaccg tttgggtcaa 1932541 ctgctataat gtgtttgacg cggcgtctcc atttggcggt tataaacagt caggactcgg 1932601 acgagaaatg ggatcatatg ccttggataa ttacacagaa gtcaaaagtg tatgggtaaa 1932661 ccttgaagac taacatgtat gtttaaaaaa ctgctgcctg ccagcagttt ttttctttct 1932721 gtaatggcag taaaagacgc tgaatatata tgcttctgaa ggagttgagc gtgatgggca 1932781 cacttcagga gaaagtgagg cgttttcaaa agaaaaccat taccgagtta agagacaggc 1932841 aaaatgctga tggttcatgg acattttgct ttgaaggacc aatcatgaca aattcctttt 1932901 ttattttgct ccttacctca ctagatgaag gcgaaaatga aaaagaactg atatcatccc 1932961 ttgcagccgg cattcatgca aaacagcagc cagacggcac atttatcaac tatcccgatg 1933021 aaacgcgcgg aaatctaacg gctaccgtcc aaggatatgt cgggatgctg gcttcaggat 1933081 gttttcacag aactgagccg cacatgaaga aagctgaaca atttatcatc tcacatggcg 1933141 gtttgagaca tgttcatttt atgacaaaat ggatgcttgc cgcgaacggg ctttatcctt 1933201 ggcctgcttt gtatttacca ttatcactca tggcgctccc cccaacattg ccgattcatt 1933261 tctatcagtt cagctcatat gcccgtattc attttgctcc tatggctgta acactcaatc 1933321 agcgatttgt ccttattaac cgcaatattt catctcttca ccatctcgat ccgcacatga 1933381 caaaaaatcc tttcacttgg cttcggtctg atgctttcga agaaagagat ctcacgtcta 1933441 ttttgttaca ttggaaacgc gtttttcatg caccatttgc ttttcagcag ctgggcctac 1933501 agacagctaa aacgtatatg ctggaccgga ttgaaaaaga tggaacatta tacagctatg 1933561 cgagcgcaac catatatatg gtttacagcc ttctgtcact tggtgtgtca cgctattctc 1933621 ctattatcag gagggcgatt accggcatta aatcactggt gactaaatgc aacgggattc 1933681 cttatctgga aaactctact tcaactgttt gggatacagc tttaataagc tatgcccttc 1933741 aaaaaaatgg tgtgaccgaa acggatggct ctgttacaaa agcagccgac tttttgctag 1933801 aacgccagca taccaaaata gcagattggt ctgtcaaaaa tccaaattca gttcctggcg 1933861 gctgggggtt ttcaaacatt aatacaaata accctgactg tgacgacact acagccgttt 1933921 taaaggcgat tccccgcaat cattctcctg cagcatggga gcggggggta tcttggcttt 1933981 tatcgatgca aaacaatgac ggcggatttt ctgctttcga aaaaaatgtg aaccatccac 1934041 tgatccgcct tctgccgctt gaatccgccg aggacgctgc agttgaccct tcaaccgccg 1934101 acctcaccgg acgtgtactg cactttttag gcgagaaagt tggcttcaca gaaaaacatc 1934161 aacatattca acgcgcagtg aagtggcttt tcgaacatca ggaacaaaat gggtcttggt 1934221 acggcagatg gggtgtttgc tacatttacg gcacttgggc tgctcttact ggtatgcatg 1934281 catgcggggt tgaccgaaag catcccggta tacaaaaggc tctgcgttgg ctcaaatcca 1934341 tacaaaatga tgacggaagc tggggagaat cctgcaaaag cgccgaaatc aaaacatatg 1934401 taccgcttca tagaggaacc attgtacaaa cggcctgggc tttagacgct ttgctcacat 1934461 atgaaaattc cgaacatccg tctgttgtga aaggcatgca ataccttacc gacagcagtt 1934521 cgcatagcgc cgatagcctc gcgtatccag cagggatcgg attgccgaag caattttata 1934581 ttcgctatca cagttatcca tatgtattct ctttgctggc tgtcgggaag tatttagatt 1934641 ctattgaaaa ggagacagca aatgaaacgt gaatcttatc aagcggagat gttcaattgg 1934701 tgtgaagccc tgaaagatca gattcaaaag cgaggtcagc ttgaccagtt tgaagatcaa 1934761 atcgacaaga tgattgaggc tctggaagat gaccaaacaa cagaagaaga ttggtataaa 1934821 caggccgctg ccctttatcg ggatattaca gaatcagatg atacaagtga aagacgcgct 1934881 tatgtcccta tagggaaaca cgtgctgcca aagcttcctt acaaatactc cgccttagaa 1934941 ccttatatat cacgcgatat tatgatcctt catcatacaa aacatcatca aagctatgtc 1935001 gatggcctga acaaagcaga atcagagctt aaaaaagcga gagcgacaaa gaattatgac 1935061 ttaatcactc attgggaaag agagcttgcg ttccatggag caggccatta tttgcatagt 1935121 attttttggt tttctatgca tccaaacgga aaacggcgtc ctacaggggc attgttccaa 1935181 atgatagacc tttcatttgg aagctattcc gcttttaaag aacattttac ccaggcctct 1935241 aaaaaagtgg aaggcgtcgg ctgggccatt ctggtctggg cacctcgatc aggacggctg 1935301 gagattttaa cggcagaaaa acaccagctc tttagccaat gggatgtgat ccccctttta 1935361 ccgcttgacg tatgggagca tgcctactat ttgcaataca aaaatgaccg ggccagctat 1935421 gtcgatcact ggtggaatgt cgtggattgg cgcgaggctg aaaaacgttt tgagcaggca 1935481 aaagaagtcg tttggaagct ctattaaaaa aagccccctt tcctcggggg cttcgtgtgt 1935541 taaaaaatac ctatcacatg caaaaacacg atgatgatgg caacaggaga tagatatcga 1935601 atgagcagca gccaaaccgc aaaccacttt cgtttgagat tggaaccgct tttcagctcg 1935661 tcaaacaaat cctgtttcgg tatttttagc ggaacaaaaa tcgaaatcag taacgcacct 1935721 aacggcatta aaatattgct cacaagatag tcagccgcat caaaaataga cagatgaaat 1935781 atagtgacgt cacttaagac accgtatgat aatgcagacg gcacaccgac aataaaaata 1935841 gcaataccgc ctaaccaagc gaatcgtttt ctcttattga tatcgccttt cgacagtact 1935901 gcgaccaaaa tttccagcat tgaaaaagca gatgtcaatg cagcaaataa aaatagaagt 1935961 aaaaatgcta ataaaaagat aattccgaac ggcatttgat taaacacagt cggcagaacg 1936021 ttaaataaca gaaccgggcc ttggtctggc ttgaggccga atgaaaatac agctggaaaa 1936081 atcgcaattc cggccattac agcaacaagc atgttcataa cagttacaga tacagcggac 1936141 tgtaccagat tttcctgttt ctctaaataa gcgctatacg ttaccatgac agatacaccg 1936201 acacttaata agaaaaagga ttgtcccatt gcatataaaa tggtattggc atcaattgca 1936261 gttaaatcag gcatgaggaa aaatttgatt ccttccatcg cgccatcaag tgtaaccgaa 1936321 cgcaccatta aaatgatgaa taatagaaaa agcgccggca ttaatacttg gcttgctttt 1936381 tcaattccgc tgcttacccc ttttgcaaca actaaaattg ttaccaccat aaagagcagc 1936441 tggcctccta cagccaaata aggatttgaa atggtacttg caaatatcgt atcaaaacca 1936501 gatgtttgcg ataaaccgcc agtgaagcct tttataatat aaattaaaat ccatccgcct 1936561 acgacactgt agaaagatag aagaataaag cacgtcacca tgcctaaata accgatccaa 1936621 tgccacttcg ttcctggagc aagtgtttta taggactgaa cggcatcttt ctgtgttctt 1936681 ctgcctatga tgaattcacc taacaataaa ggcagtccga ttaaaaccgt aaataaaata 1936741 aaaataagta aaaatgcgcc tcctccgctg gttccggcaa catatgggaa tttccatatc 1936801 gcaccaagcc cgatagctga tcctgccgcg gctaaaataa agccgagctt cgaagaccat 1936861 tgatttgctt ccttcaccgt atcactccta tttgatctaa ccattataaa ggttcattgt 1936921 aagaatatct tcctatatag tcaagaacat tttaattagt ttacatcata tatctataga 1936981 catctgccaa aaactaatat tgaattattc agaaaattat ttataataag agaatgttat 1937041 gaaatttgta agaatttctg ctgaagttct tgataagtgt gttaggagtg tttttatgga 1937101 catcattaga aaaataagcc attttgcagg acaaaccttt ggcatatggg tcattgtttt 1937161 tgcagtgctg ggattttctt tcccatcttt atttacgtgg atcagttctt atattacgat 1937221 ttttctcggc attatcatgt ttgggatggg ccttacactg caagccgatg atttcaaaga 1937281 gctggtcaga aagccttggc aagttattat tggagtaata gctcagtata cgatcatgcc 1937341 gctcgttgct ttcggcctcg catttgggct tcatcttcca gctgaaatcg cagttggtgt 1937401 tattcttgtc ggctgctgtc ccgggggaac tgcatctaat gttatgacat tcttagcaaa 1937461 aggaaatact gccctttctg ttgcggttac gacaatttct accttattgg cacctgttgt 1937521 aacaccgttg ttgattatgc tgtttgccaa agaatggctt cctgtctcgc cggggtcttt 1937581 gtttatctca atcttacagg cggttttatt tccgatcatt gcaggtctga ttgtcaaaat 1937641 gtttttcaga aaacaagtgg caaaagccgt acatgccctt ccgcttgttt ctgtcattgg 1937701 catcgttgcg attgtctcag ctgtcgtcag cggcaatcgg gaaaatctgc ttcaatcggg 1937761 gttgctcatt ttttcagttg ttatcctgca taacggtatc ggttatttac tggggtttct 1937821 ttgtgcaaag cttttaaaaa tggattaccc gtctcaaaaa gcgattgcaa tcgaagtcgg 1937881 catgcaaaac tccgggcttg gggctgcact tgccacggct catttctcac cgctatctgc 1937941 cgtaccaagc gcaatattca gtgtgtggca taacctttca ggttctatgc ttgcaacata 1938001 ttggtcaaaa aaagtgaaaa agaagcaagc tggatccaaa agcagcaatc tatcacttta 1938061 aatatgcatc aaaaagggta catcacttta tcgtgatgta ccctttttta ttatccttct 1938121 aataaaagct gttcaggatc ttccagtaaa tttttgattg tcacgaggaa accaaccgct 1938181 tctttaccgt ctacaattcg gtgatcataa gataaagcga tatacatcat cggacggttt 1938241 tcgaaacgct cttcatcaat ggctacaggg cgcagctgaa tcttatgcat gcccagtata 1938301 ccgacttgcg ggctgtttaa aattggagtt gacatcaatg aaccgaaagt ccctccgttt 1938361 gtaatcgtga aggagcctcc ctgaagctcg ctaagggtta atttattgtt tcttgctttt 1938421 ttcgcaagct cgccgatctc tttttcgatt cctgcaaatg tcaggcgatc cgcatcccgt 1938481 acaaccggaa cgacaagacc ttcatcagca gcaacagcga ttccgatatc gtagaatttt 1938541 ttaacgatca actcatcgcc ttgaatttct gcattcaaca gcggatattt tttcaatgca 1938601 gccacgaccg ctttcgtgaa gaaagacata aagccgagct tcacttcatt ttgctcaaaa 1938661 aattgatctt tgcggcgttt tctgagattc atgacagccg tcatgtccac ttcattaaat 1938721 gtagtcagca tcgctgatgt ttgctgtacc tctacaaggc gttttgcaat cgtttgtctg 1938781 cggcgtgaca ttttttgcac ttcaacaggt ttgtcaaagc tttgctgtgc tttttgagcc 1938841 tgaggctgct gcttttgctg aggagccggt tttgatgccg gtttttcgta cgcttcgaca 1938901 tcctgcttgc gcactcttcc aagcggatct ccagttggaa cttgagacag gtcaattcct 1938961 ttttctctcg caagcttacg ggccgacgga gaagcgatcg ttcttgattt tgcttcagat 1939021 tgtgcttcct cgctcacctc ttgtgcagct ggttcagcct gtttctcttc ttttacgctt 1939081 tccttgcttt ctgttttctc tgtaggagca ggggcagaac tttcacccgc gccttctgaa 1939141 atcgtaccga taatttctcc gacctggacg gtatcacccg aatctttcaa tacctcttga 1939201 agtacacccg attcttctgc tgtcaattca acattcactt tatccgtttc tagttcaagc 1939261 agatattcac cctgttctac atagtcacca ggctgcttta accattgggc tattgttcct 1939321 tctgagattg attctgctaa ttcaggtacc ttaatttccg ccattttttc atttccccct 1939381 tagtttttgc gagtcaagct atcagataca atacgttcct gttctttttt atgaactgtc 1939441 ggatctccct ctgcagggct ggatcgtctt cttcgtccaa tatattgaac gcttactccc 1939501 tctggtgcaa tctctgtcaa atacgggctg atataacccc aagcccccat gttctgcggc 1939561 tcttcctgca cccaaacgat ttctttcagg ttcggaagtt ttgcaaataa ttctttgact 1939621 ccttttgccg ggaatggata cagctgttcg attctcgcaa tgtgaagcca ctctttaccg 1939681 tcttctaact tattaaaatg atcgctaatg tctatagaca ctttaccgct ggataataca 1939741 agtctggtta ctttttcata gtcatgagaa agtcccgact gttcataaac aggctggaag 1939801 cggctttcgc tgagctcctg cacttccgac accgtatttg ggttgcgaag aaggctcttc 1939861 ggcgtcataa tgacgagcgg tctgatttct tcacgaagca gcattttagc ctgtcttctt 1939921 aaaatatgga aatactgtgc cgcgcttgtc aggttggcaa ccgtccagtt gttttccgct 1939981 gcaagctgca ggaatcgctc aattcttccg cttgagtgct caggcccctg tccctcgtaa 1940041 ccgtgcggga gcagcatgac taatccggat ttttggcccc atttcgcgcg tccggcagaa 1940101 ataaattggt caaaatacac ttgagcagcg ttggcaaaat ctccgtactg tgcttcccac 1940161 aaaacaagcg tttccggtga atgcacgtta tagccgtatt caaaaccgag aaccgatcct 1940221 tcagacagcg ggctgttatg aacagcaaat gatgtgctgc agtcagataa gtgatgaagc 1940281 ggcacaaatt ctttgcccgt ctcactgtca tgaagcacaa ggtttctttg ggcgaacgtt 1940341 ccgcgctcgg aatcctgtcc tgttaaacga atcggtgttc cgtctttcaa aattgaagca 1940401 aacgcgagtg attctgccaa agaccattcc acttttctgt catcatcgaa cgccttggcg 1940461 cgtctttcta aaatgcgctt tagcttgccg aaaacattaa atgactccgg ccagttgatc 1940521 aattcgccat tcagcttgcg gagcacatca aaatcaatcg aagtgtccac atctgggaaa 1940581 ccgtttgata caggctctgg aagttcaatt tcacaagcag tgtgttcctt tttagacgga 1940641 actttctgat atgcatcctc aatgcgcttc gttaccgatt tttcgatgtt ttgaacgact 1940701 tcctcggtaa ccacgccttc ttttaccagc ttttcagcga aaatttgttt gacggtcgga 1940761 tgctttctga cagcatcata cagcattggc tgagtggttg acggttcatc catttcgttg 1940821 tgtccatagc gtctgtaccc gatcaaatca atcagaaaat ccttgttgaa tgtttttcgg 1940881 tattcgaccg caaacttaac agctgaaaga caagcttcag gatcgtccgc attcacgtga 1940941 acaatcggaa tttcataacc cttggccagg tcgctggcat attttgtcga tctggattca 1941001 gcgctttctg ttgtgaatcc gatcatgtta ttggcgataa tatgaatcgc accgcctact 1941061 tgataccctt ttaaagagct taaattcaat gtttcagcta caattccttc cccagggaat 1941121 gcagcgtctc catggattaa aatggccagc gattttgttt catcttgtac cgggtatccg 1941181 ctttgtgttc gcgtttcctg tgccgctctt gtgctgcctt caacaatcgg attgataaat 1941241 tccaagtggc tcgggttgtt cgctaacgta atgcgcgctg attttgtttc agcgtcttga 1941301 agctcccgat tcgcccccaa atggtatttg acatcccccg tccatccgta gctgattcca 1941361 atggatccct cagacggtac aagatctttg ttcggcgcat gctggaattc agagaagatg 1941421 atttcatacg gtttgccgag cacatgtgcc aagacattca ggcgtcccct gtgcgccatc 1941481 ccgatgttga cacttgtcgt gcctgatttg acagattgtg caataatgtc atcaagcact 1941541 ggaacaagag cgtccagacc ctcaatggaa aagcgcttct gcccgacgaa tgtgcggtgc 1941601 aaaaactgct caaagccctc tacttctgtc aatctttcca gcacagctga cagcttttca 1941661 gctgagttct tctggaacag ctcgccagat tcaatctttc ttgtcagcca ctcgcgctct 1941721 ttgaagtcat gcacatggtc aaattcaaaa gagatggttc ttttatacgt atttcgtaaa 1941781 tactgaatgg cttctaaacc gttcgaaatg tttttaggag cgtctttgca gatgacagac 1941841 gcaggtattg cttttatttc ctcttctgtt agcccgtaat cggataatgg aaaaagttcg 1941901 ctctttttct catcctttct gagcggattg acggaagcgt tcaaatggcc ataggttcgg 1941961 atatcttctg caagtctgac tgcggatgcg atcttttgaa tcagatcggc tgtaacacgt 1942021 cccttttctt ttgttcccga ggcctctttt atatcgcttg gcggagcacc gagctcgtcg 1942081 aacatttcct tcaaatccgg gtcaatgctg ttcggatcct gggtatactg atcgtaaagc 1942141 tccagcgcat agccgaggtt cggaccgtaa aaatcttccc aattcattcg ttgtttcata 1942201 ctattttgaa acatttgaat attaccccca acttaaataa tcaagtgatt gattcactat 1942261 cttgaaataa ctttcgaacg ctgtgtccaa aattatgtaa taaaaacgct tccaacgata 1942321 ttttaccact gtttgcaatt tgattctacc ttgattgttc acaaaatagt aaaaaacctt 1942381 tataaaaaac aaaaaattta atcattcgaa aaaacaaacg ccaaaaagca taggattaag 1942441 ggctatccta tgcttttatg aagcagtttt ttcagcagcg gatacaaaac atccggtagc 1942501 tgatcaacat ccgggacaaa tatactgaat tttccgtaca tatcctggat cgtcttcatt 1942561 tgcgattctt ctatttctga gttggagaga aaaacattta tcacttctat tcctcttttt 1942621 cgggcttcga taaccgcctc acttgtatca acgatcccat tttgttcgta gccaaatgcg 1942681 gccggctctc catctgagaa aacaattaag aacttttgcg cctcgctgcg atgcagcatt 1942741 tttttcgtca tctgcctaat tgcgtacccg tcacggttat cttcttctgg ctcaagctgc 1942801 ataatggccg gtccagaatc ttgtcttaat gatgattgga agggaataac cgtattgaaa 1942861 tagtttggct ggcttttttc ggttgcatca tttgtgtcct cccaaaaacc gacaatctga 1942921 tgcggaaccg ctaccgattt caacgcttcg tgaaacagca cgattcctcg ttttgtttcg 1942981 tccattttgt cgaacatgct ggcggaacaa tcgaccagca atgtaaaaac tgcgtcgatt 1943041 tctgaagatg gttcttgctt tttgtagaac aggcgcggat ttcgctcagt gaagtaacga 1943101 agaagcttat tgttcagtct cccggcatga aggtctgttc tcggcaatgt ttttttatgc 1943161 tccagcgttt tttgaatcat ttgtttcaaa cgcttttgat acgattcaat cgtttttgcc 1943221 tgctgtttat aagaaagctc ttcttcactg gttgccggct gcggttcttt ataaattgga 1943281 aatgcatatt tattttcttt gccgtcagcc atacccgctc cgttcggctg gtctttttgg 1943341 gactccagcg cttccagctt ggaatagtct ttccgtttcg tttgtctggc tgatccttga 1943401 acagagccaa gggcctgatc tccatcgtcg ccttcccttg aagcatcttt tcctaaatct 1943461 gattttgcgc cgtgttcaat atcaaattga aggaagcttt tagacggtgc ttctgtttcc 1943521 cggtgccatg tcggcatttc ttcttcatgg atatcctcat caccgtctga ttgttttgga 1943581 agcgtgatgt catcactcag cttcggcgct tttttctctt cttcaaataa cggctgttct 1943641 gcagcttttg cgtaatcaag ctcaggcaaa aagaagtagg tgttcaacat gtctttatcg 1943701 agtacctctt caagtccgtc catgaggtcc tcaacaattt tcagaacctg ccgtgtcgaa 1943761 tctgcttcat acacacgcaa gagctgctgc tcaataaacg ggcgcatcag atcgatatct 1943821 tcacgcatgg atggaagggt ctcgagcggc gattccgctg tgagcttgaa atagatcgcg 1943881 caaaagagcg catcggtaaa aatgcttcgt tccaaattta aggtcagctg ggttgagaaa 1943941 tgttttctgt acatgtcttt tcgcttcgca aatacatgtt tcgtacccgg gcgctcacgt 1944001 ttgatgcatt cttcgatcct aatgtcttca agcagcataa agagctgctt ggcaaaactt 1944061 ttaaacgtaa gatggcgatg gatatcattc aaaaagttcg caaactcatg cagcgagcta 1944121 tatcttgttc cgactgaacg caggtagacg tcgcttttca gacccgcttc catgtcctca 1944181 gctgccctgt ctttccaaaa gtggctcata tagattttct tttcaaatgg attgtaatag 1944241 gactgaacgc catactccac ttctaccgct tcactcttgg tgagtgtttt ggccaaatca 1944301 gtcagcatca taaataaaaa tgaatcaatc gtgctgtcgt taaatttgat aaatttcatc 1944361 gcagccccct cattcaaaca gagtttctgc aatatttcgg acagccgctt tttcccgatc 1944421 atcatcaagc ttttctacaa ttccccgctc aatggcacga cgcggcggaa tataagcagc 1944481 taaatcacat gtatcgatta aagctctgat ggatgccgct tcttcagaca cctgtccgtt 1944541 attggcctga acgatcaagt cagaggaaag cgtgataaat ctgtcaatca atttctcgtc 1944601 tttcaaggct gactgagaca tgagcacttg tttcagcagc tcgcctttaa tataaggcac 1944661 atcaatgatg acaaaacggt ttttcaacgc ttcattcaga ggaacagttc cgacatagcc 1944721 ttcattgatg gctgcaatga ctccgaaacc gcttttagcc cgtatgacct cgcctgtaaa 1944781 cggatttgtc atcatttttc tgtaatctaa tacaccgttt agaataggca gtgtttccgg 1944841 cttcgccata ttgatttcat ctatataaag aaaatggcct tccttcattg cctttgtaac 1944901 aggtcctgaa acaaactcga ttgttgcctg gccagattga ttttcaatcg ttttataacc 1944961 gaccaatgcc tcagcgtcca agtcgactga acagttgacg ctgtgcatcg gtttatgaaa 1945021 atagctggac aatgtttctg ccagctttgt ttttcctgaa cctgtaggcc ctttcagcag 1945081 gacatttttc cccatggcta atgcaataat ggcgtcaaat aaaatggctt catcctccgc 1945141 ctcatagcct gatgttccta taagcgattg aaactctggg gaaataggct gctctttata 1945201 tgataaaagc ttttgttgta tatcttccgg caatgttaag tgctgtagtt gagttgtcat 1945261 agacagattc cctttcctat tcatattcca ttaacgagta tactaaaaaa gcccctgtat 1945321 gctcaataca aaagggcctg gatgatatta ctgcttctcg ttatttccca aaagggctcc 1945381 gcagacaata cgcgcaccgg aattgccgct tgggtttgtc agataatcgt ccgcttgttc 1945441 atgaataata aatgcacttc cgtcctcgtc gagaatattt agtttacttc cttttttcag 1945501 tgaagtgtca ggcgcattca ttatgacatc tacctttcca tcagcaccga cttcaaggtt 1945561 cggcagatct ccggcatgat gccccatcgg attattaaag ccgtgttctt tgttcagtgg 1945621 attaaaggga ccgcccgctg attcaaaatc cggcctgaca caagaacctt tctcataaat 1945681 atgaaaaccg agagaagcac ctggacgcag gctgtttgcg gaaatatgaa tatcgaggcc 1945741 ttcatcatct gattctttga tctctataaa accgactgct ttcccttcac gattgaccag 1945801 ctggacatga tgaccaaacg ctgacgtttc aaccactttt ttttccggca cccggttagg 1945861 agggtctgga ggtttttttt gtccgcatcc ggcaactccc agtgccgtca gcatcatcaa 1945921 cagcaagaga cggtgcatac tgtctccccc ttgttttttc taacagtgtg gtcaatcatt 1945981 gtctggtata aacaaaaaag cctataaaag gctttttgtc atactcattt ttaaaaataa 1946041 cttcttgcgc ccaagtaccg ctgtttccaa tacgaattgc tgagattgga aatgtcgacg 1946101 cccgatgagc ttgcatgaat aaaatcaccg ccgcctagat aaatccccat gtgagacggg 1946161 ccggatttat atgtggtaaa gaagacaaag tctcctactg acggctggct gactttctgc 1946221 atgacattcc aataccctgc cgtactcaat cttgatatag atgatacatt attaatgagg 1946281 taataaatga agccgctgca atcaaaaccg gcaggcgtgt ttccgcccca tcggtaaggc 1946341 actccgacat attttttcgc ttccgttatc attctgtcaa tcttcgaacc tatttgaatg 1946401 tttgaccctg agttatcttt tggctttgtt ggctttgtcg gatttgaagg attagatttt 1946461 gatgctcccg aaatagtcag aacctgcccg atttgcaaca catccgatga taaattgttt 1946521 ttatcacgga tgctttggac agtgactccg agccgatttg caattttcca cagcgaatcg 1946581 cctgctttta ccttgtacgt cgttgttttt gagggattgg agtttgacgg ctttttggaa 1946641 ccgctgtttc cgttcttagg tgaactgctt ccttttattt tgagcacctg tttaggataa 1946701 agtgtatctg atgttaagcc atttaaggtt tttaattcgg ctacagtcat atttaagctg 1946761 tttgcgattt tccacagtga gtcaccaagc ttgaccgtat atgtactttt tgaagaacct 1946821 gaagaattgg aaccgctgtt tttctttgat ccatttgatc cgcttgaact gcttgtccct 1946881 ttgatcttaa gcttttgccc cggacgaatc aggtcactgc tcaggctgtt taagctttta 1946941 agctcagaaa cactcatttt atgattttta gcaatcatcc atagggaatc accatatgca 1947001 actgtgtatg ttgatgtttt gcttgaatta gatggggatg tcgtgctttt tttgctgctt 1947061 tcaggaacct taagactttg tccgacataa agcaccgttg atttcaattt gttttcggat 1947121 ttcagagctg atattgtcgt atcatactgg cgggaaagtt tccaaagaga gtcaccgctt 1947181 tttactttta tcgtttttgc ttccgcgggt gctgcggcca tcgacgaccc aacaactgca 1947241 gaaacagcca agccggctac aatcttcttt ttcattcatt caacctccta aactgttttt 1947301 ttgcaaaaac agctagtatt ttgtttccaa aaatggcaca caactgtttt atcgtcaatt 1947361 tttcagcaag ttaaaccctt ttcaaacatt tggcgcagca ttttcagcat cgttcgacct 1947421 ttaaaccttc aaataaacat ctaacatttt acataagcac gatatgtttt tcgaaagtct 1947481 aaggaactat ttaagcgagg gtaaaaatga tggttttcta ttgatgaacg aagcagtttc 1947541 tcctcctttc ttgtctattt ttctaatcaa ttctctatcg gcgtgtcaaa tcccttcctc 1947601 tgcattctta tgaaatggca aaaagcctgt tctttcgata agaacaggct tttacactat 1947661 gcatttgctg attgagtttt ttgttttaca gcttcaagaa tgctgtcggc tgctttttta 1947721 gagccgcctg ccgctttcag tgattgtcca atttcttttg ccttttcagc atacgaacga 1947781 ttattcatta cttcttgtat cgtctctttc agtaggcttt cagacaattc ttccttttta 1947841 attacttttc ctgcgccgac tttttctacc tgatctgcga caacaaattg gtcgcctccc 1947901 atcggaatga caacgagcgg ggtttcaaaa tacaaacctt cacttgtgct gttcattccg 1947961 ccgtgggtca caaataagct ggctcttttc aagatctcaa gctgagggac atacgggcgt 1948021 acaatgaaat tctccggaat gtcgtttaac tcacttgttt taatatgctt gccgatggaa 1948081 agcacaactt taccgtcaaa gtccttacac acttcaaggc attgattaaa aaactgcttt 1948141 tgattattaa aaatggttcc cattgaaata aacagcacgt tttcattgtc aatctgatca 1948201 aatgggaaat cattgtttcc ggctctttct gtaatggaag gaccgacaaa tacatatcgc 1948261 tcgccaaatt gctcagccag tggctgaaat ccccttgatg taaagacgat tgtcaagtca 1948321 ccatcagcta aaaaaacatc aaatggcttc ttgatctctg cttgaaaatc agcatttaac 1948381 gtttctgcaa gctgctggta tgattcataa tgaggcgaat cttcaagtga tcctttcatg 1948441 tacgctccca tcatttcctt cgcaaattcc tcattcatcg caaaggttgt acacaatgaa 1948501 aatcttggca gcttcagcat gttggcaatg actttacccg cgagaagatg gtgatcatat 1948561 atgacataat catacgattc atgtttgact tcctcataaa tatgagtcgc gatatcctta 1948621 caggctttca aaaaagcgca gagcatttct gtgaaatctc tttcttcatc gccggttgcg 1948681 tttttcccga agtaatctcc tctgaaatca tgatactcac gaaactctat atcaagagct 1948741 gtgatttttt ctttatattc cttcactgcg tagtacgtaa tgttttctcc ccgggatttc 1948801 agctccttca tcacaccgat agagggatta atatgccctt caccggggaa accgatcatt 1948861 aatacattag ccatgcggca gcacccttcc tttgagaatt tatgtaatat tttatacggt 1948921 actataaatg cataaacagg taaagtattt cacttaatta atattcatca tatataactt 1948981 ttctaccagt ttatattccc tgtcttcaag acaaaaagca ttcagcttga agcgaatgct 1949041 ttaataaaga tgcgaattca gtcattttgt ctcatgatag gattcttaat caggcccttt 1949101 ttattatttt tacgttcttg gtgaaattaa cggatataat acaccgtctt tggcaaacga 1949161 catcttccct gtttcctctg aaaccacgag caccagtgca tccgtatagc ccgacatacc 1949221 aagagccgcc cggtgccggg ttcccaaatg gatatccact tccttcgtcg tcagcgggag 1949281 cacattggct gctgacacga gtttgttttc cctcactaat aaagcgccgt catgaagagg 1949341 gtttccggga aaaaagatgc tttcaattaa tgaagagctg atctcggcgt gtagggaggt 1949401 gcctttttga ataaaacgtt caaccgggtc tgctctttca atcacaatta aagctccatg 1949461 cttatgttcc gataaggctt taatcgcctt ggccagctca ataaatgccg gcgtaaattc 1949521 ctcaatgtat gattgcaaat aaaaggagga tgcaatcccc tgcatgtcct gaaaaacgtg 1949581 ccccaaatca tctaattcac aaaggagaca ctggtctttt tcgtgaagcg ttttcaagat 1949641 tagagatgca tcacctaata tttgctctaa gtacacctgt attttcccct tgaacgcatt 1949701 ttctgatatc tgctcatagc gcatagcctt catctcctgt ttaaatttcc aacttttcac 1949761 gaatgcttat cttattgatg cacattctat tggtaaagga gggatgtaaa gaatggaaat 1949821 cgaaagaatc attcagtata tttgcacctt tttaggcgtg atttcgcttt cttttattta 1949881 tgcccaaatg tttagaaaaa cgaaaccgac aaaaaaagaa taggcccggc gttcattgct 1949941 ttttatacat aaaatgttat aatttctctc gttatgaaaa agaaacggag atcaatgtat 1950001 gaaagaaact caaaacgccc gggaaaaaat caaacagctc ttgcacattt taataccgat 1950061 attcattacc caagcggggc tttctctgat cacttttcta gatactgtga tgtcagggaa 1950121 agtcagcccc gctgatttag ctggtgtcgc cattggctca agcctttgga cccctgttta 1950181 cacaggactt gcaggtatat taatggcggt caccccgatt gtcgctcagt tattaggtgc 1950241 agagaaaaaa cagaagattc cctttactgt tttacaagct gtatacgtgg ccgcgcttct 1950301 tagcatcgcc gttttagtga ttggatatgc tgcagttgac cttattcttg gccgattgaa 1950361 ccttgatatt cacgtgcatc agattgctaa acacttttta ggctttttat cactgggaat 1950421 tttcccttta tttgtttaca ccgtgttgag atcattcatc gactcattag gaaaaacgag 1950481 agtcaccatg atgattacac tcagttctct tccaatcaat tttgtattga attatgtatt 1950541 tatcttcggg aagttcggaa tgccggcact tggaggtgta ggcgcgggac tggcatccgc 1950601 gttaacttac tggtgtatat gcatcatcag ttttttcatt attcataaaa acgcaccgtt 1950661 ttctgaatac gggatttttc ttaccatgta taagttctct tggaaagcat gcaaaaattt 1950721 gctcaaaatc gggctgccta ttgggttcgc cgtgtttttt gaaacgagca ttttcgcagc 1950781 tgtcacgctt ctcatgagcc attttcatac agtgaccatc gcgtcccacc aggcagccat 1950841 gaattttgcg tctcttttat atatgctgcc gcttagcgtg tccatggctc taacaattgt 1950901 tgtcggattt gaagcgggtg cagcccgttt taaggatgca cgctcatata gcttaatcgg 1950961 catcatgatg gcgatcggct tttctttgtt cactgccgcc tgtatccttt tattcagaga 1951021 gcaaattgcg ggcatgtaca cttctgaccc cgatgtgctc cggctgacac agcacttttt 1951081 aatttatgcg ctattttttc agctttccga tgctgttgcc gcaccgatcc agggagcact 1951141 cagagggtac aaagatgtga actatacgct tgcggccgct tttgtctctt actgggtcat 1951201 tggccttccg gtcggttata tggtcggtac gtttacaagc ctcggtgcat tcggctattg 1951261 gattggatta atagcgggac tcgccgccgg agcagttggg ctgtttttca ggctggcaaa 1951321 actgcaaaaa cgttattcgc aaaaacaaca catttaaaag aggtgatcaa tcatggcaaa 1951381 aaacaaaaaa ttattcgagt atctttccca gcatgcggaa accatcagtt caacatggta 1951441 tgaaacaatc gaggagactg atcccaattc catttatgcc tcaacagacc ctgttgtcat 1951501 tcacaattta aagagccaga atcttgcctt taactataaa ataaaccgta tttttataga 1951561 tgatgaggac gtatacttgc ctatactgaa agaatgggcc tttgaagtca cacaggatca 1951621 agagcattta aaaactccta tccactatat tattcgggag tttgtcagag tgagagattt 1951681 atatgtttct tatgtgaaag aatttgtcca tctcaatcag aatactgtga aaagcgaaga 1951741 agccgaagac ctgtatcacg cccttataaa agcgtttgat cttgtgattc atatttttat 1951801 agaagaaatg tacaaaaaca caagccttca gcttcaggcc caaaaagata tgattactga 1951861 attgagcgct ccggtcatcg tgctgtttca cagcgtcgga ctgctgcctt taatcggaga 1951921 tattgataca gtccgcgcca agctgattat ggaaaacaca ctgcatcaat gtgcgaaaaa 1951981 aaaggtgaca caactgtata ttgatttgtc aggagtagct gtgattgata cgatggttgc 1952041 ccatcagctg ttcagtctga ttgaggcgct tcgtttaatc ggtgtttctt caactttgtc 1952101 tggaatccgt ccggaaatcg cgcaaacagc ggttcagcta ggtttgtctt tcgaaggtat 1952161 ttccttgaga tccactctcg cttcagctat tgcatcggac ttaaaattaa aaaaggtata 1952221 aggcttaagg ccttatacct ttttgattaa tcattccatt gatacgtcca atatatttct 1952281 tcttcaaacc atgttgccat aacaggttca ttatttttca atttctcttc aagctctctg 1952341 agcatgcctt ctgtttgtgt gcggtgagct cttaacgcat tcattttaat atcagctact 1952401 tctttgatat caagtacgac atcagcttcg ccgagaacct cttctctgtt gcgggtaatg 1952461 gccatgcaga ttgtacgcgg acggtcttct ttctttttgc ggtataatgc acggataacc 1952521 gcttccccgc atgcatcatg gtcagggtgc acaccgtgtc cgggataaaa tgtgacaatt 1952581 aaacttggtt ttacatcatc tatgatctct tccatgatat cagctaaata ctcatcgtct 1952641 tcaaattcga gcgttttgtc acggagtcca agcatccgaa ggtcattgat atccatttct 1952701 ttgcaagcgt tgatgagctc ttgttttctt agcagcggca acgtttcccg attcgcgaaa 1952761 aatggatcgc ccatatttct gcccatttca cctaaagtgg cgcaggcata cgtaacggga 1952821 atgtcttttt ttctgtttaa ggcaatgagg cctgccactc catatgattc atcatcaggg 1952881 tgaggcagga ttactagtac atgttctttc attattattc acccttttct ttaaactgtg 1952941 aacggttttt cgctgatttg cagagaaata gccagtttac cgcccggcag gtgtcccgcc 1953001 attaataaac ggttttcttc atctaccgtg tattcagtca agccttcagc ataaatccag 1953061 ccttcttctg ttttcaagcc aacgcggtaa ggcccgttgc ctttgatttt tgcctgatga 1953121 taagtgactt ttgcattgcg aatatacgca acaaccgtca tgttcttttc atttaagtgc 1953181 gctgaataag aacctgtggt ggtttctaaa tggatatata cagggcggtc cgcatatcgt 1953241 tctaaagatg cttgcacatc ttcttttatg atcgctttca tgattgctcc cctctttctt 1953301 cttttaaata ctctgcacgt tctgtatgta atttgaccag ctgatatttc acagccggtt 1953361 cgagctgtga attcacaatg cgctgaatcg cggcaaaata tttttccagc atcggttttc 1953421 ggagtcttgg atgtgttcgt ttatccaaga gctcaagatc aatcgcctct gctaccgctt 1953481 ctgcgtcatc atgtgcgaga gatcggttat tccaaagtga agcataggct ttcactatct 1953541 ctttatcatt gtccatcgtc ttgctccttt atgtcttaca tacatgaaat gattatacat 1953601 aatatatgca tcagctgaaa agccaaaggc ctcaatggct ttttgacgcc cgtttccact 1953661 tcacttgtga aaacgtaaac aagagcagcg cagcccatat acagctgaat gtaaaagcct 1953721 tcgagcttga aaatggctca tggtaaacaa acagcccgat cagcagggta atggtcggcg 1953781 caatatattg taagataccg acttgataca gtggcagccg tttcgctcct tccgcaaaca 1953841 ataagagcgg caaagccgta aacacaccgg ccaaaaagag aagcagccac gtccctccgc 1953901 tttctgcacc cgctggctga acatgtccgc tgaacagcaa ataccccaat gcaatgggca 1953961 taatcatgaa tgtttccagc gttaaaccga tggcgctcgg caggcttgtt ctttttttgc 1954021 ttaacccgta cagcccaaag ctgaatgcga gcagaagcgc aacataagga atggagccgt 1954081 attggaacgc cgagatgatg acaccggctg ccgcaatcga aacggccact aattgcaggc 1954141 gattcagttt ttcctttaaa aataaaatcc caaggagcac tgatacaagc ggattaatgt 1954201 aatagccaag actagcctca agcaaaaagc catggttgac agcccatatg tatacaaacc 1954261 agttgatcga aatcaggata gaagcaagaa ataaagagag gatccctccg ttctttttca 1954321 gagagcgcaa ctcctgccat cctattttcc attgccgcaa gaaaaaaagt acgatacaca 1954381 taaaaacaaa agaccatata atacgatgag ccaaaatatc aagagccggc agctgttcga 1954441 gaagcttcca atagagcgga aacaggcccc acatgataaa tgaaacggct gtgtaaataa 1954501 cgcctttttt tgtttctgca tgttgcattg atatccctgc ctttctttag agcatcttat 1954561 attatatcac gtgaaagatc tggtgggcat atactatttt gtccgtgaag aaaggatgtg 1954621 aagacaatgt ttgagtggaa caagtacttt cctttccaca atcaattttc taaagaagca 1954681 ttaaaaaaag ctgatccgaa agaagttgaa acgtatgtca atcgtgtgat ggaaagtgtg 1954741 ttcggcagtg attatgcggc tcaatttcct ttccgcgatc ctctccccca aaaagaacat 1954801 cccgccaaac ctgatgcaaa acctgatgtc aaacctgata ttgatatatt cgaaacagca 1954861 gaccatgtgt ttgtaaaggt gccaatcagc gaagaatggc tggaacaagt gagaatcaaa 1954921 cacacatctc acgaattatg gttggaaaac ctcccaagag cagatcatcc gaaaaaagta 1954981 aaccttcctt gtttagtcaa acgcaaagga acaaaagccg tctataagga tggccttctg 1955041 gaagtcatgt ttcaaaagca gcaagactac aatatgtccg aggtagaaat catccgataa 1955101 aaaacggcct gcaatcgatg caggccgttt tttattaata gaagccggga tatcccccgt 1955161 atggcacgcc ggcaccaaaa ccgtacggtc cgcctccata tccataaggg ccaggaggat 1955221 aggcataggg acgagaatag ttaaacagcg cactcccgag aaaaccgcct aataaaccgc 1955281 cgactagagg agcgccaaac aaaaaaggac tacgcgccgg atatccggct ggacctggga 1955341 ttccgcgtaa atacgaatga tgagggtaca tgattttttc ctcctttatg tctgcctata 1955401 cgtaaagtat tcagcaagga agaaaaacga ttgggctacg gactgtctat gattgttaca 1955461 tcacaagccc tgccaataac acacagccga gccctgtaac cgaaagaact gttgtaagca 1955521 gcgtccaggt ttgaaatgtt tctttcatgc tcaagccgaa aaattccttt accatccaaa 1955581 atcctgcatc atttacatga cacgcaatga cactgccggc tcctgttgca agcaccatta 1955641 acgcagggtt tacactgcca gcctccataa gcggagctgc cattcccgct gtggtaagcg 1955701 cagccacggt agcagagcct agacacagac gcagaaccgc ggcgatggtc catgcaacga 1955761 atagcggcga catgtttgtt tgacggaaaa aatcagcgac ataatcgccg actccgccgt 1955821 caatcagcac ctgtttaaac gctcctcccc ctcctatgat gagcagcatc atcgcaattt 1955881 gcgaaattga ttctgaaata gatctgccga tttcctgcat agatatttta cgggcatatc 1955941 ccatcgtata gagtgcaagc aacagcgaaa tgagcattgc cgttcccgga gtgccgataa 1956001 attctataat gtcttttcct tttgaatgtt cactcaataa taaagaaaaa attgttgcca 1956061 ttgccataaa gataaccggg aataaagacg tgacagcact gatcgcaaag cccggtgttt 1956121 catccagctg aaattctttc cttggtccta accccgatag gtttccatgc ttttgatacg 1956181 caccaggaaa ccgtttcatc gcaaatttat taaataaagg cccggcaatc acagttgtcg 1956241 gaacagcgat gatgattcca aaaagcagca cctggccaat atgggcacca tatgcaactg 1956301 agatagcagt tggagcagga tgcgggggca aaaatccgtg agtaacattt aaggcggcgg 1956361 ccatcgggat tcccagatac agaaaaggca tttttaattc tttagcaatc gcgtaaacaa 1956421 tcggtatcaa cagaacaaga ccgacttcaa aaaatagggc aatcccgatg ataaaagagg 1956481 caaccacaac cgccgcctgt attcgtttcc tcccgaattt gtcaatcagc gtaatggcga 1956541 tccggtagcc gcccccagca tctgagacaa gcctcccaag catcgcgcca agtccaaaca 1956601 ctaaagctaa atgccccagc tgcccgccaa ttccagtctc aattgaaaga acaattttat 1956661 tgatatccat tccaagtccg atggctacta aaaatgaaac gacaatcagt gagacaaagg 1956721 tatttaattt tactttaata atgagaaata acagaatcag cactccgaca gctacaatta 1956781 aaatcggcat ggtacccctc caaaagtgtt ttatatgatt ctcgcgacaa tgttttggcg 1956841 cttttcatgc ctagatgaac agaaagcgct ttcattaata actaaaaacg tcttggttat 1956901 atgattgtta tcttttgatc aactaatatg ttcatactaa tctcctaatc aatgactgtc 1956961 aatcgttttt atgagcttgt ctcgattacc taccgcctaa cccaatgatt tattagttat 1957021 atgttgatta acttttggtt atatgttatg ttttttaaag ttgactgcca atcattatat 1957081 ctctccattg tctggaagca aatgagacaa tatgagaaca gacggataac aacttcataa 1957141 gaggaggagt acacatgcca ttattgcgtt ttgatgtaat tgagggccgt gatgaaaaat 1957201 cgctgcaatt gttattagat actgctcacc aagcgatggt tgaagcattt ggtgttccgg 1957261 aaagagaccg ttatcaaatt gtccatcagc atcccgcaaa cgagcttata atccaggatg 1957321 cgggattagg gtttcagaga accaaggata tggtcatcat tagcatgaca agcaaagcaa 1957381 gaaccgaaag ccaaaaggaa aaattgtatg ctctgcttgc tgaaaggcta gaaaaaaaat 1957441 gcgaaatttc ccctgacgac ctcatggtat ctattactga gaatggtgac gcagactgga 1957501 gtttcggtct cggtgaggcg caatttttga atggaaaact ataagatttc gtctccccac 1957561 aaaaaaaaga agagagagct ccaaagaagc tctctctttt ttcataaatg cggaagtcat 1957621 cagtatagaa gcatccagca atacgaaaaa cctggatctc cttttatatc cggtttaaat 1957681 gccaattgga agctgactgg gttttggctg aaaatataaa attttgctga tttgcataat 1957741 aagatacatc ataatcccca tttacaatag gttggatgtt atagcttatt gatcatttcc 1957801 tattttatat atccccttca tatgcacatg acatttttgc caatccggaa atatcagtct 1957861 gacaaatata aaaagtcatg taaacgggtg tgaaccgtac ttacatgact caccatggaa 1957921 acaaaggctc tttttcaggt gccgctttcc ttatttctct tcttcacaca ctgtgtcacc 1957981 aggctcgcaa aattgatcgg cccatgcctg catttcttga aatacagctt gaagcgctgt 1958041 tcctttttca gtcagcgtgt agatgacttt gaccggcgtt tcagggagaa cctgccgttc 1958101 gacaatctcg ttttgttcaa gctccttcaa gcgctctgcc aacatttttt ggctgatcat 1958161 cggtattgtt tccgttatct ctttaaaccg tttcggccca tccattagca catggatgat 1958221 cagaccgttc catcgttttc ccagcaatga gaatgcggat tccattttag ggcacatcgt 1958281 atttcccata agtcttcatc ccttcatcta ttgattgaca tgtattcaat gatccattac 1958341 aataatcttt caagttacat ttagtaagct tctaactttt ctattatcat accacgttta 1958401 tccgaaggag gaaacactat gacgaatact ctggatgttt taaaagcacg tgcatctgta 1958461 aaggaatatg atacaaatgc cccgatctct aaggaggagc tgactgagct attagacctt 1958521 gccactaaag cgccttctgc ttggaacctt cagcattggc attttacagt attccacagc 1958581 gatgaatcaa aagcggagct tcttcctgta gcgtataatc aaaaacaaat cgttgagtct 1958641 tctgctgttg ttgccatttt aggcgattta aaggcaaatg aaaacggtga agaagtttat 1958701 gctgaattag caagccaagg ctatattacg gatgaaatca aacaaacatt gctcggccaa 1958761 atcaacggtg cttaccaaag cgagcaattc gcacgtgatt ccgctttctt aaatgcttct 1958821 ttagctgcta tgcagcttat gattgccgca aaagcaaaag gttatgacac ttgcgcaatc 1958881 ggcggattta acaaagagca gttccaaaag caatttgata tcagtgagcg ctatgttccg 1958941 gttatgctta tttcaatcgg caaagcagtg aagcctgcgc atcaaagcaa ccgtctgccg 1959001 ctttcaaaag tatcaacttg gctgtaagga tatgaaaaac cttagtccga aatccggact 1959061 aaggtttttt tatacaatcg cctctttgta ccattcacga gcctgttcag cttcatgctg 1959121 agtcagctga tggcccccgt cctgccagta aacggaggct gatgccccgc tgtcacgcaa 1959181 atagcggtaa agctcttctg attcttcctt cgtgcaaaga ggatcgtatt tcccggcacc 1959241 gataaaaaca gggagccccg ccatatcagg cagctcgata ccccgaatcg gaaccattgg 1959301 atgatgcaga atagcccctt ttaacacatc tttataatga aaaagcaggc ttgccgcaat 1959361 gtttgcgccg tttgaataac cgactgcaat cactcggccg cgattaaact gatgcgtttc 1959421 tgcagcctcg tcgataaaat ctttcaattc tcttgtccgc accacaagat ccttttcatc 1959481 aaaaactcct tcactcagac gtttgaaaaa tcgcggcatt ccattttcaa gcaccgatcc 1959541 tctgacacca agcaaatggg catcagggtc tataaaccgc cccaatgaaa gcagatcgtg 1959601 ttcattacca cccgtgccat gcaacagcaa aagtacgttg tcagatgttc ctttctcata 1959661 aatatgcttc attataaatt ccccctttta aagttcaggt aaaatgtctg taatttgttg 1959721 tctatgtttc tccagccatt caggcagttt taaggaagtc cctagctcag caaacgtttc 1959781 atctgtcata aagcccggtt catctgtggc aatttcaaat aagataccgc ctttctccct 1959841 aaaataaact gatgtaaagt attccctgtc gagaatttct gacgaaggca gatggttttc 1959901 agcaataatc ggcagccatt tcgcctgttc ctttttctta gtccgaaacg ctacatggtg 1959961 taccgtacca tatcctccga ctcctctttt ttcaggatgt aaatggacat caatgacacc 1960021 gccgaccgcc gctgaagatg ccagtctgac aatctggtct tcttcggcca ctttggtgta 1960081 tccaaagctt tccgttaaca attgtatggt cgcctgcggg tcgtaggaat atagcagcac 1960141 acctttcatt cccgtaattg cttcatttgt tgtgatcccg tcaggcgtcc actcgctttt 1960201 gccgcttttc gcatcctcca tgatcgccag cggaaggtct tctgtatcat caaaaataag 1960261 acctttttca ccaaacaacg ttttttcctc taggctcagc ccgcttttct caagacgttc 1960321 cttccaaaaa gacagggagc ctgagggaac tgaaaagtac acccggcccg cttggccttt 1960381 tcctaccgtt ccctgtccgc ttccttggaa cggaaaaaag gtcattattg taccgggatc 1960441 tccgttttga ttcccaaagt aaaaatgata cgttccggga tcatcaaagt ttactgtttt 1960501 tttaacgagc ctgagcccaa gcacttctgt ataaaatcgc aagttttctt gcggatctct 1960561 ggcgaatgct gtgacatggt gcaatccttc tgttttcatt ttctcactcc tatttatctc 1960621 gatttcaaga tatttattat tttaaacctt tattgaaaag gatgcaaacc atgtgttttg 1960681 attaaataat tgaaaaaatc atttttttct aataattatc ttgtgatctt ttcttacaac 1960741 tgctattata gtgagcatta tcatgtttca ggaggaaagt aaatggttaa aaaagcactt 1960801 attgttattc tcattctttt gccattcgtt cagctcgcgc ttttgccgct tgtgaatcga 1960861 atagaaccga ttatgttcgg cctgccgttt ttccactttt ggctgctgct gtggattatt 1960921 gttacgccgt tatgctcgtt tggcatttat cagatgcaaa aaaaagatgg aggacttgaa 1960981 taatgcaagg gaatctgact gcacttctca ttactgctat tattgtttta accgttgtct 1961041 gtatcggctt tctcgccgga agagacaaat cctcacgtac ttctgtggaa gaatggtctg 1961101 tcggcggcag acgcttcggc ggtcttctcg tctggttttt agtaggcgct gacctttata 1961161 cggcctatac tttcttaggg ttgaccagta ctgcttttac aggcggaagt gttgcatttt 1961221 tcgccattcc ttattctgtg ttggcctact ttatcgccta cttcttcttg ccaaaacttt 1961281 ggaaagttgc gaaaattcat aaattaacaa cactcgcgga ttatgcccgg gaacgtttta 1961341 acagtaagct tttggcaagc ctcgttgcca tcgttggggt actcatgctt attccgtaca 1961401 tatgccttca gctgagcggc attcaagaca cgcttcaggt tgccggcact ggctatatta 1961461 acgtaaaatt cgttgtgatc atttcattta ttcttgttgc tctttacaca ttcttcagcg 1961521 ggattaaagg gcccacatat acagccatca ttaaggacat tttagtatgg gtcattatgc 1961581 tgtttatggt ggtgtccctc cctctcattc attttaacgg ctggacgcca atgattgaca 1961641 cgttagtgaa ggaagcgccg caaatgctga cgataccgtc agaagggcca aaaggcattc 1961701 cttggtttat cacagcatct attgtttccg ctctggcact ttttatgtgg gcacatgccg 1961761 ctacaggtgt tttcacggcg aaaagcgctg atgcagtaag aaaaaacagc atgtttttgc 1961821 cgctttataa tatcgtgtta attttggtta tttttcttgg ctttatcgcc tttcttgttc 1961881 tgccggaaga tacaaatcca aggctggcgc tgctgcattt gattcaaaca tcttacggcg 1961941 gcgtggcaca aggctttgca tatgccacta tcgctcttgc ttcattaata ccttgttcca 1962001 ttatggcaat cggcgcatcg aatttattcg ccaacaacct ataccgggat ttgattcatc 1962061 cgaatgtgtc gcaaagcaag ctgactcttg tcacacgttc aatggtgttt gttgtcatcg 1962121 gtcttgcgct gctgtttgga atgctgttcc cgactgcctt agtgacactt cagctattag 1962181 gtgtatccgg tatggtgcaa atcttccctg cgattgctgt cagcctgttc tggaaaaacc 1962241 aaacgaaaga agcaacggtt atcggattat tagccggcct agcggtaacg tttattgtgt 1962301 atatcactca atccgcacat ggcatttatg aaggattctg gggattggcc gccaacatga 1962361 tcgctgtggt catcctgaat ccgctgttcg ttaaaaacgc gggatccaat cctgtcattg 1962421 aaggtttatt tggcaaaaaa caagacgcta atccaaatca aaagggcgca taaaaaaacc 1962481 atacgcggca gccgcgtatg gtttttttta catttctttt ttcagtgttt caattgcctt 1962541 ttccatttgc gtatcattat cagacagctt cttttgaagt tctatcatta atttcgttgt 1962601 tgtatcgcca gtcagtatgc ctgtttcatt cagcttctct tttttctgga actgtttgac 1962661 gacagataca aaatcctggt catacatact gttaaccttt accttgtaac caagtgcttt 1962721 gagcattttc tgagccactt tgacgtttgt gcctgtatca cctgatttgt acgttttatc 1962781 tgcgtccaaa tacggcagct tcgcgtaatc aggcagctct gctttcactt gaggcttgat 1962841 gccttttttg tgaatccatt cgccatcagc agtcagccat ttggcaactg tcagtttgac 1962901 ggtagagcca tcatcatatt cttttgccgt ttgtactgta cctttgccga atgtcgtctc 1962961 gccgattaac ggtacgtttg acgattcatg aagggcagcg gccataattt cggctgcgct 1963021 tgctgtaccg tcatttacta aaacgacggt cggcttggtc actttccgtt ctttttcggc 1963081 cttcatgact tcttttgaac cgtttttgta ttcaacctgc atgatgtttt tccctttatc 1963141 aatgaacagg ttgctcatcg taatcgcctg ttccattaag ccgcccgggt tgcctctcaa 1963201 gtctaaaata tagcctttgg cgcctttttt ctctaaactg tcaatcgcat ctgtcagctc 1963261 tttagctgtt gtttcagaga aagaagtgat ttgaatttct ccgatgttgt tgtctttcat 1963321 ctctgaatag acagtctcta caggaatggt atcgcgctta atggaaagat cgatattccc 1963381 cactcccgct ctgttcagtt caagcttcac ctttgtgccc tttttgcctc ggattaaagc 1963441 gacggcttca tttacattca tgccttttac gctttttcca tttaccttaa tgatttggtc 1963501 cctcggtttg ataccggctt tttcagcagg tgaaccttta attggggata caataaggat 1963561 ttctccgtct ttctcctcta cttgggctcc gattccttca aaagatgctg aaatcgtctc 1963621 gtcgaatgat ttcgcttgct cttgatccat atatgtagaa tacggatcat ccagtgattg 1963681 aatcattcct ttaattgctc cgtctactaa tttgtcatca tctgtttttt ggtaataatc 1963741 acttttgatt tgctcatacg ctttatttaa tttgtcgaac ttgctgtctc ctgtgcttgc 1963801 tgatttttgg cccaggatac tggaattgcc cgtaataaat aaagtaagcg ccgaagcgac 1963861 aactgcagtg atcagcacaa taaaaaacag ttttaattgc cgtttcaatt aaacaccacc 1963921 tttttcttct tacattatta tcatggacga attcttattc gtcaactcgg agcagaaatg 1963981 aaagagaaac gcccttcttt tgcttttcat aaacctatgt ctttatacga catatgataa 1964041 ggaaaaagga ggattcgata ttgagccgat atttagaaat gctgtcctta ttcggtgtcg 1964101 caggggcgca cccaggcggg ctggcttttt caaaagcggt cttgcaaaag gctgcaccct 1964161 ctccggatca gccgattctt gatgccggat gcggaacagg gcaaacggcg gcttatttag 1964221 gacatttgct gtatcctgta acagtcgttg ataaagatcc tattatgctt gagaaagcga 1964281 aaaaaagatt tgcgaatgaa gggcttgcca tccctgcata tcaggcggag ctggaacatc 1964341 tcccgttttc ttctgagtcc ttttcctgcg tcctgtcaga atcggtcctc agtttttcac 1964401 gcctgacatc ctctcttcaa gaaatttcaa gagttttaaa acccagcggg atgctgattg 1964461 gtatcgaagc tgctttaaaa aaaccaatgc cccctgcaga aaagaagcaa atgatggatt 1964521 tttacggatt tacttgctta catgaagaaa gcgaatggca taaactccta agatcctatg 1964581 gctttcaaaa aacagaagcg atgtcacttc ttccggaaga catggaattt gaaccaacca 1964641 cagaaatgga tttatcgcaa acgattgatc ccatctatta cgatacgctt caaacacatt 1964701 atcagctcat gcagttatat agtgagtaca tgggtcattg tatttttatc gcgtacaagt 1964761 aaaacggcgt atcgccccct gttttcgtcc aacctttttt tcctatctat catatgctga 1964821 tagaaagtca ggataggagg ggaacaatat tggagagata ttatcatctt tgcaaaaacc 1964881 atcaaggtaa agtcgtcaga attacagaga gaggcgggag agttcacgtc ggcagaatta 1964941 cccgtgtaac aagagacaga gtttttatag ctccggtcgg cggagggcca agaggtttcg 1965001 gttacggata ttggggcggt tattggggat atggagcggc ttacgggatt tccctcggtt 1965061 taattgcagg agtggctctg gctggtttat tcttctggta agcatagaac aaatgctaga 1965121 ttcaccagac acaatgaagc ccgcttatct agtgtaagcg ggcttttcat tttaaatttt 1965181 cttcactttt tcaaagtact cttcaagcgt taaatcatta tcttggatga cctttgcggc 1965241 ttttttgcct acatagcgca gatgccatgg ctcatattca tatttcgtga tatcttcttt 1965301 atttttcgga tagcgaataa taaagccata tttataagca ttgtcctgca cccatttccc 1965361 gtctgccgtg cttccgaacg cttcatttag ctcaaagcca ttgctccggc tcgaaatgtc 1965421 catcgcaagg cctgtttgat gctcgctttc acccgggtaa gcgaccgctt cctttgcctt 1965481 cctttcccct tttaggctta cttcattgtc aaaaatgact ttctgtctgt catacgaacg 1965541 gtaccctgag acagctgcca gttcatagcc ttcctttttg gcagcatcga acattgtttt 1965601 taatgcgtcg gccgcttctt ttctgatgta acgtttttga atcttttctt caaaagaaaa 1965661 ctctacatca ggtatgacaa gatcgctagg ttcatagttt ccgggcagtg catattgttt 1965721 attgacaagc gcgagtatat tttctggatt ttgaatggtt tccagaccat cgactttttt 1965781 aatatcattg aaatactggc tttccaatga aaactcactg ttttgagtgt ttgatttttt 1965841 gctgtcagct gttttttgtt ctgtttgctt tgtttctgct gtggttttcg tatccttttg 1965901 agcatctccg ttcgacatgc tgcagccggc tccgactatt gccgttacac tcagagcggc 1965961 agccagtgag aaccatttac cggacttttt catattacat taccttcctt ttatcaatcg 1966021 tttccgcatg cataaagaag aggctgccgg cacccagcac gcctcttgat atattttatt 1966081 gtgatacgga atgtaaagcc acttctatca tatcatgaaa tgtcgtttga cgctcttccg 1966141 ctgtcgtttc ttctcctgtt aatacgtgat cactcacggt gagaattgac agggcttttc 1966201 ttccgtgctt cgctgctaat gtatacaatg cagttgtttc catttcaacg ccaagcacac 1966261 cgtattttgc aagtttttca atttgcgaat cgtcattgta gaactggtca gctgtaaata 1966321 cgcttcctac agtcaccggc acacctttat cctttgcggc atcataggca ttttttaaaa 1966381 gctcgaaatc tgcgcaaggc gcaaaatcaa cgcttccgaa agcaactctg ttcatttgtg 1966441 aatcagttga ggaggtcatc gccaaaatga cgtctcgcac tttgacatct ttacgaatag 1966501 cgccgcagga accgactctt attagatttt gcacatcgta gctttgaatt aattcattca 1966561 cataaattga aatagacgga actcccattc ccgtgccttg tactgagatt tttttacctt 1966621 tatatgtacc cgtaaatcca tacatgcctc tgacttcatt gtagcattct acattttcaa 1966681 gatacgtttc tgcaataaat tttgctctga gaggatctcc cggcaaaagc acagtatccg 1966741 caatttgtcc tttttcagca cctatatgta cactcatctc atatcctcct gtaaatctaa 1966801 attatcatcc agcccgtcca ttttacaacg aatgtcatga tgaaacaaac ttcagcattg 1966861 attataaagg aatatatcga aaaaagaaat gttcgaggat ctgttaggca cttcctcaga 1966921 aaaacggata atcggggtgt taatttgaaa acctaaccgc aggaaggagg ggtgggacat 1966981 gggtaaaaaa catcgtaacc ggatcaccgg ccaaaaaaag aacaatcata tacctgaaaa 1967041 agatatcatt gcagctgaag aagcacacgg gaaagaatat tccgctgcca aacgcaagcc 1967101 ttaaaactgc agaaaactgc gggtttccgc agttttcttt tcattatgtc gtttgtacaa 1967161 tcagacgatt gattttcctc cagccggcgg gaagcagttg ataatatgtt ttcccttttc 1967221 tgccttcatc aatcaggatc acgtcccctg tggccatgaa tcttgcatca taatcactcg 1967281 gaacagtgtc gaatacatta aacaaagaga atgctctttt cagcacgtct tgatgatcgc 1967341 tcccgttcag ttcagttcga tagacggctc tgtagccctt tttttcgcca aaccggggtg 1967401 tctgaaatat tgtcacgtca taggaacaag acttcttttt aaacacggat aacatcatca 1967461 agatcccctc ccttttattt ctttaacata ttggcgtttt tgctgtgttt tcctctctct 1967521 atttttgtcg aaaccgctta atcttttcgt caaaaccttt tactaggaaa aacagaagca 1967581 agccgaggct aaagcctcct aacacgtctg tcacaaaatg aacccccaga tacactctgc 1967641 ttatgccgac taaaacagca attacaccgg ctatgatata taccattttt ttatgcttag 1967701 acaaaaacgg gagatgtttc actaaaaagt aagcaataac aggatagaca caagcagcat 1967761 tcatggaatg gccgctcgga aaactgaagg atgattcatg aaccagcggt gcaaaatcag 1967821 gcctcactct ttcgatccat tcttttaaga ctttgtttaa cagccgatct gtgccgaata 1967881 ctaagagcat caacaggccg tcccatgttt ttctgtagaa aaacatgcct gctccaatga 1967941 tgacaattag agggagcaga aaagaagaag caccaagatg cgtgatcccc gtcatgactt 1968001 cattaagcca tggctgacgg atcaaaacag ctgccttgct tattgcttca tctgcagatt 1968061 gaacagcatt tgtatgaatg gccgcagcta gaattaaaaa gaaaagaaac aaactaacgg 1968121 gcttgtacaa ttttaaccac ctcaattttc acagaagtca tagaacatga ataataaaac 1968181 cggagctgac cgctccggtt ttaagcctca ctcatcttca tccagctctt catctatcat 1968241 acatttttct atcaaataat caaaggtaat atcagcgatt tcaaacagct catcctcact 1968301 cggtatgtag ccccgtcttg caagctctct gtaaaaaaat tcagcgattt cttccgtatc 1968361 aatcacaaga tctatttctt tcatctccgt accgcctcct tttttatgtt ttatgaaaaa 1968421 acaggctgaa ttatacccgg tgttctaaac aattctttca gtcatatatt gaataaaaaa 1968481 cgagccatgg gaggctgacg ctatgattgc taaaatgatg gaagcactgg acggagaaag 1968541 atttgatatc ataatggaaa aaacgctcaa aggaatgacg cgtgtgatga tttggggctg 1968601 tctgccatat tttttatatg tcttgatccg tatgttcaca aattaactga aatgctcttt 1968661 taaactttcc aaaacaaaca tcatcatgtc tttatattct tcatcctgaa acatttcgta 1968721 cagaattttg tagtcattat aaatatccag aagctcatca acaattgaca cagcaaggat 1968781 gtgaagggta tcttgatctt catcaccgcc ttcaaactga agaagagcag acgatgcgat 1968841 atcttcgccg atctcatggc cagtttctcc gacataatgg acaaacaaca gctgatgcac 1968901 aaactggtcc atttcatatt ttctaagcac cagcgtgaga tcctcttcct ccgtttcaag 1968961 ccactctcca tcctttaaac gggtcagctc ataaatgata tcttcccagc catcttctaa 1969021 atatctccaa atttctgttc tatggccgat aatgcgaaag agttcttttc cataatcttt 1969081 aacataaaca acgtccccaa taaggaattc atactcaata tcaagcttct ccatgtcgac 1969141 aatgacaccc tcataatctt tataaagctg aatagatgat tcaaagtata aaacttcgtt 1969201 atgattgact tcataaagat agtgtttatc aatttggtgt acttttgtga tggtgccgac 1969261 tgttccatac ataatgacga ctacgatatc ccctacttgg aatttcggtt tattttgctt 1969321 catggtgtct ccccctcgcc gcaacatttc tcatacgcta tcgtatgccg ggtgaagcca 1969381 attcgcatgg gcatgaaaac caaaggaaat atccaattat ggtatgggta tggacataaa 1969441 aaaatccgca gtgatctgcg gatgaaacag ctattatctg ccgtgcactt cagactcgta 1969501 ttgatcccaa gcttcatcaa acgtcgccat cgtgtgaagg taatcagcat tcagctccaa 1969561 atatgaactg atttcatgat aatcggttga tgtttttgga aagctgtgat cctcatacgc 1969621 ctgattggca aattcactga tgctgtcctt cggcttaggg tgtctgtatt tcaataaata 1969681 gtgataaaag gatttcatgg gtttcccctc ctgatgtctg tcttttgttg ttctattata 1969741 cagttcaagt gtaaaattac aacaaaagaa tactgaaaca tgactcagga gaagtcaaaa 1969801 tagttgcgtt tcaaaattct ttctgtctcc atgagctgct gatatgtcag gctttcaggc 1969861 agtttttttg tttgaattaa aagcagctga tcctcaatct ctttaaccgt gttttcctct 1969921 tgataggtca taccgcagga agaacatacc atggcagggg tgtctgtcag ttctatagcc 1969981 ctcgttccat cagggagctc ccagtacacc gtgttcctgc cgggcaccgc ttcgagctcg 1970041 ccgcaccatt cgcatgtttt catgaagaat cccctccgca ttcagtctct ttctgttttt 1970101 tctgctgcgc caaaaatttc ttttctttga gctgatctct tttctcacgc cgatctttta 1970161 atgtttcatg ctccggattt gcgatgtatg cctctctcct tttgattctg tctacatttt 1970221 caggtgtaaa cgaaacttct ttgtcagcaa aaatggcact cagcccgatc ggctcctttt 1970281 tgtcagcggt ttcagggaaa acggactcaa aataggcgtc tgcctgattg gggatataat 1970341 tctctggttc cggatatgac gtaatcacac cttcaaaatt tcttaagatc actttgtcag 1970401 gactttgtga caggacatag tttggctgca gggcgatttt acctcctccg cctggtgcgt 1970461 caacgacaaa ggtaggaacc gcatagcctg aggtatgacc tctcagccct tcaatgatct 1970521 ccaaaccttt ggaaacagga gctctgaaat gccctattcc ttctgacaga tcacattggt 1970581 aaatataata aggacggact ctgattttta ccaagtcatg catgagcttt ttcataattg 1970641 gaaccgaatc attaatacct gctaatacga cagcctgatt tccgaccggc actcccgcgt 1970701 tcaccagctt ttcacatgcc tcaacggatt cttctgtcat ttcgatgctt gtgttaaaat 1970761 gggtgttcag ccagaccgga tgatattttt tcaatatctc gcacagatga tcggtaatgc 1970821 gctgcggaaa gacgacggga gctcttgttc cgattctgat gacttccaga tgcggaatgc 1970881 tgcgcagctc ttttaaaata tattctaaaa tttggtcgtt gatgagcagc ccatcaccgc 1970941 ctgaaattaa acaatcgcgg atttcgggtg tttcccggat ataagcaatt gcagcatcaa 1971001 gctgtttttt ggggacgccc attccgattt gtccggaaaa gcgccttctt gtgcagtagc 1971061 ggcagtacat ggaacattga ttcgtgacaa gaaacagcac acggtcggga tagcggtgtg 1971121 tcagaccggg taccggtgaa tcttcatcct catgaagcgg gtcttccaga tcgtattttg 1971181 ttttgtgcat ttcttcagaa agcggcacag actgcatgcg taccgggcat ctcggattgt 1971241 cggggtccat taaagaagca tagtaaggtg taatatttaa ggggatcgtt ttggtagaaa 1971301 ttctgacgcc ttcctcttca tcctcggtca gattaatgac tttctttaaa tcatctaacg 1971361 ttcttacagt gtgtgtcagc tgccaaagcc aatcgttcca tttctcttcc ggaacgtcct 1971421 tccataactc gatctccttc caatgccgtt tcggtttata ccatttgttt ttcaaacgaa 1971481 ctcctcctcg cgcatatttt gacttacagt tgcttgcacc aaatattcat gttttcaagg 1971541 ccttcggcta taaagcaatt attgatcagc cttccgccat actgataacc tgaatggtac 1971601 aacacagcat tcatcccaaa agacgaagca cgggcgagag aaaacacatg aacgatatcc 1971661 tctccagcca tttctttttc taacgcctcg attaaaaagc ttgttaacga atggccgcga 1971721 tattccggca gcacagcgca atcggttatt tctgcatgcc caagctctgg attgatttct 1971781 gcgcttgctg cgctgatcag gcggtcatga tcaagcatga tataatacac cgtatttgca 1971841 ttcatcgtct tttcaatata agcggggtca aataccgggg ttgggtacgt gcggaatact 1971901 tttttataca gcatcgatag ctggtacatg tcgtttgttt ctgcttttct catcgtaaaa 1971961 acgggtgtac tgtcgttgcg aagacggggc gctgtgcgat atatggcttc gatgatctcc 1972021 tgttcctctg tataagaatc tgtttgtctc cggctttctg aaaggtaacg taccatgaca 1972081 caagccgaat ggccgagata atagcccttt agatagccct ccggcgcaaa taattgtttg 1972141 gcaaggatcg gctcatcatg ctgcttcgca tagacaatga ttttttctgc attctcttct 1972201 tttgccgctg ccacgatatc cggcagggcc ttctcaatgg ctccgtcata acgaaccact 1972261 ctgattcgtt tattaaagcc gtcatggtcc aaaactgctg tgacaccgct actctttatt 1972321 gacttgagca tccgcatcct ccccatctgt atgaaggccg caccaatcca tgacaaaaag 1972381 tgcaataatt ttagcagatt ctatcatggc ttcaacctca atgtattcat tggcctgatg 1972441 agccgttttt gtttcccccg gcccgaaaac gatcactggt gtatctcctg catggtacaa 1972501 aagccctcca tccgttcccc acggggaagc ctcaataatc ggctctgtct gtttcatttt 1972561 ttgataggct gattgcagca cagaaattaa agggtgatca tcaggtaaat cattcggcag 1972621 ccattgagcg ccaaaccatt cgacttgtac gggatggcgt ttaaaccatt cgtcatggta 1972681 ttctaaatcc ttcagccagt tttccaattc aagttttaca gcttctggtt tctcatgggg 1972741 agcaattccg catctccctt ctatgacgac acggtctgca actgaagatg gccaggcacc 1972801 gcctgagatg gtgccgatat tcaccggtac cggtattggg atattgtcat acagcggatc 1972861 tgaaattctc gcattgcgga ctttctccag ctcttgtatc gctgtgataa cgtgcatgct 1972921 tttttcaatc gcgcttaccc cttcatagcg tgtgccccca tgtgcggata atcccttcac 1972981 agtgatccga aaccacatcg aaccctgctg cttaataaat agtttcatat tcgtcggttc 1973041 aggaatcagc gccccgtcag cacgatagcc tctcatgatg gcggaaagtg taccggcgcc 1973101 gccgcactct tcatctacaa cactctgaaa caatacatct cccttcagtt tgacatcgca 1973161 ggcgtgcagg gcttctaaag caaaaagaag ggctgtattg cctcccttca tatccgttga 1973221 gccgcggccg tatattttac cgttttcttc gacagcttga tacggttcat acttccaatc 1973281 ctttacgctt ccttcaggca caacatcgat atggccgttc aaaatcaggg acctgcctcc 1973341 gccggctccc gtttttttag ccacgatatt cgggctctca tgaaaatcgg atcggttaga 1973401 tttaaagtag ggatgctgtt ttaattgctt tatgcttggc tcccatacat caatgtccat 1973461 atgaaattgc cgcagctttt caagcacaac agcttgggcg ttaaactctg accccaatgt 1973521 gcttttttcc ccaatcagcc ttttgagaag acgaatggct ttggccgaat gctgatcaag 1973581 ccactcgatt acttttcttt caatgtcttg catcctcatt ccccctctta agaaaaaggc 1973641 atatctattt tgatttcagc ttctgtcagc ctcgtcacct catcgattgt cgagccattc 1973701 atcagctctt ttaaaatgaa gtgatggcta tcgacctcaa gaaccgcttt ttcggtaata 1973761 atcaaatcta cacagcctgc agcagttaat ggcagcgtac atctttctgt taatttaggc 1973821 cttccctttt gatctgtatg actcatgacg acaaccactt ttttcgcttt ttgggcaagc 1973881 tccatcgccc cgcccatacc aggcaccttt tttcccggaa caagccaatt tgccaaatct 1973941 cctgattggc tcacctgcag ggcgcctaaa atcgtaatgt caattttgcc ttttctgatc 1974001 atcgcaaaag acatggttgt atcaaaataa gaagcccctt ttacagcgcg gacaggatat 1974061 cccgcggcgt tgcataaatg cgcatcctct tctccctttt cgggactttc tccaatgcca 1974121 aggacaccgt tttccgcttg aaacatgacc tgcatgtcag gcttcaaaaa gttcggtacc 1974181 aaggaaggga taccgatacc gagattcaca atcatgccct gcttaatttc agtagcagcg 1974241 cgttttgcaa tctgttctct ttctgctact cccaagccca tttccacttc actccctcgc 1974301 ttcgtacaac cccctcaaca aaaacccccg gtgtgacaat catttcttca gaaatctccc 1974361 ccatcggaac gatacgctca gcttcggcaa aggttctcct ggcggccatt gccataagcg 1974421 ggttcatatt gcgcgcggtt ttgtcatacg ttagattgcc gaattcatct gcaatgtaag 1974481 cattgatgaa agcaaaatca gcagtcagcg cctcttcaat caagtatcgt tttcccgcca 1974541 ctgttacgat gtcctttttt tcgcaaacca tttgattatc aatgcccacg tcggttaaaa 1974601 taccgccaag ccccgctccg ccggcgcgaa tccgttccgc aagcgttccc tgaggtgaaa 1974661 attgaacctc taacgtcccc tctgtcatct gttttccggc tactggattg gaaccgatat 1974721 gcgaggcgat cagggttttg acccgttgat taacaataag cgggccgatt ccgatatccg 1974781 ggaaaccggc gtcattgcaa atcacagtca aatccgttac accgctgtcc aatatcgctt 1974841 caatcaatga aggaggcgac ccgactcccc caaaaccgcc aaacatcaga accgatccat 1974901 cccgaacatc tgcaattgct gtgtcaatgc tgattgcttt ttgaaatggc gccatttaat 1974961 gtcaatcctt ttttaagttt ttttcgaccg ctgcaactgt ttctgaaaaa atagagataa 1975021 gctcttccat ttcaccgtct gaaatagtaa aaggaggagc aataatgaca gcatctcctt 1975081 ctccactgtc tattccagct ttggaaggat aaacaatcag cccgcgtttt ttcgcctcgc 1975141 tgacaataag ctgggttatc gcctgctctg gcggaaacac tttcttcgtt ttttggtctg 1975201 ccacaaattc aatgcctaat agcagtcctt ttccgcgcac ctcacctata atgccgcttt 1975261 gagatgccgc ctcatcaagc ttcttcttca gcacagcgcc ctttttttct gattgtttga 1975321 tcaagccgtg ctttaacaca tatcgcaaaa cttcaagagc agctttggct gaatagggat 1975381 gtgcactata tgtgtgaccg ctcataatca cacctgaccc ttgttttatg gtttcaataa 1975441 tagaatcaga tacgacggca gcagcaatag gtgcataccc cgcaccgagt cccttcccca 1975501 gtacagcaat atcaggtacg gtatcccaat gctctgtcgc gagcatcctt cctgttctcc 1975561 caagccccgt catcacttca tctgcaataa aaagcacatc gtgtgtgcgg catacctcac 1975621 ttaatctctc ataatatccc ggaggcggag taatcgctgc tcctgcagca ccaataatag 1975681 gctcagccac aaagccggcg atgaattggc ttccgattct tttaatcatg gtgtccagtt 1975741 catcagctgc agtctgaaca aagtcttctt ccgtctcgtg attcagccga taaatatgtg 1975801 gagctgagat agctggatac cgctcaatga gatgggtgaa ccggtatctc ctttcataaa 1975861 aaccagacaa tgaaagcgct cccaaagtta ttccgtggta actgctccat cgagacaaaa 1975921 agatggattt ttgtgtttgc tttttttcct gccaatactg aatggcgatt ttcatagctg 1975981 tttctatcgc ttctgatccg ctgttgacaa aaaaagacca attcacatct ccgggcagct 1976041 cctgtgccaa gagagcggct aattgctcgg cgggctcact cgtaaactgt gagcggtaag 1976101 caaaagacac ctgatcaagc tgttctttca gcttctcagt cacatcacga actccgtggc 1976161 cgatattaca tgtcaccgca cctgacgagc cgtcgagata tttttttccg gtctgatcat 1976221 aaacatatga acccttcgca taactgacaa ccggataggc cgagctaagc tctggcttaa 1976281 tcaaataact gctcatgctc ccacctcaaa acccctttta ccatattgta tgagtgtcca 1976341 aatggcggca tgacgttccc cgcaaaaact ttttcacata aaaagagcct tcctaataag 1976401 gaaggctctt ttgaaatttc agcatctagc aaataaaagc ggctccaaca ataattaata 1976461 aaatgaacaa gacaacaatt aacacaaatg tatttgtccc gcagccaaat ccgtaaccgt 1976521 acccagagta tccatacatg ctgttttcat cctttcttat cacgatatac gacattttat 1976581 gcgggccaag tcccaaatgg tttgtgcaaa cgcctatttc atgtaaggaa ataatgaaat 1976641 acagtatgca cccgctcata ttttttaaac gtcagctttt cgtaaaactg agttgcaccg 1976701 tcagtgcttg cagccactaa gtaggctgct tccattccta gtgatttggc gatggacagc 1976761 atttctttca ctaagatact gccgtagccc ttcctttgaa actgatctaa aattgccact 1976821 tcttcgattt tagccgtttt ctcttgatga tcgataaaca gctcgccgca cccaatggga 1976881 actttctgtg cctggtcgct gtaacaaaca acaagaatga ttatatctgc ttcatagaaa 1976941 ggatattttc tttttaattt ttgttcagcg attgcttctc caatataaat ggaatcgtaa 1977001 attttcataa tagaagatcc gtcgctaaga ctttttgccg tcccccatgc ggttaaagga 1977061 tgtcccatct gccccttcca gtcactaagc ttcatgtcat atagtagctc atcctcgacg 1977121 acaaaaccgc tttttacaag tgactgcttc aaaccgagcg gaaaaacatg ctgcggcgac 1977181 gcttttaaat ggagataatt cgcatcaagc agctttggta cggagggtaa aaagttaagt 1977241 aaccgctcca atggaaacgt atcatggagc tgaacaaagt tatgagaaaa aatttgcgga 1977301 agctgcggat ctctgtatac gctgtaatga tcaaacgatg ccgattcaga cgttaacaat 1977361 atatattgat gttccgtttt tgaataatgt cctgtcatga acgtctcctt tttatgacct 1977421 atacctttac tctgttgcaa tattcaattt ctttataatc tcatcgtaca ccggataaaa 1977481 cggctttcca attggaaatt gctgaatatt tcggaaagaa gcggagattg gcttctgatg 1977541 taaaaaaaac ttccttgtta cttgttcact aatcgggtga aagacgccgt ttagaaacaa 1977601 aaacggctcg cgttcgatga aaaacagacg tcggccaggc ggatttttga tcaattcaga 1977661 tcgtttccac gtaatcggcg gcccttccgg aagcgtctcc atctcttctt ttccaattgt 1977721 cactatgtct tttctttgaa attgataaaa ttgaaacgca tactggtcca caattcgcct 1977781 tttttttccg gcttcgatat aaaatattgc aggatggtca gcttccttta ctaaaatata 1977841 attcggaatg tttaaaattt tgccaatcct atattggaat aaatatgggt ctggaacagc 1977901 gacagtccga tttagataca aaaaacccca cttttctcca acaggatgcc ttacaccctg 1977961 atcaaaaaaa tacacatttt gatctgaacc ttttacaaaa gagccgtcaa tcaaatcggc 1978021 gggcagaaac cgatatgcat tttgaaatga atctggggtt ttataggttg tgtctaatac 1978081 ttcatttatc ggcagaaatg gggtaaagtt gttgagtctc gcccaaaaaa ttgcgtcgcc 1978141 atgattccaa tgcttcatat catcatccca gtagcctcca aatttatggt gaatgagatt 1978201 aagtaacgaa cggcgatgca taactgagca atgatcaact tgaaaagcgg cctgatcaag 1978261 cactgcattg gcatttctgt agaaatgtga gatttcctct cccctttcgt ttacatgtac 1978321 aactttttgt tttgaataga ccgcctgcgc ttcaggctta tgtgaaaact cttgcaccat 1978381 acggctcagc cgctcaggat gataaacagt gtcgtcagta agataggaaa tgtaatcgcc 1978441 gtctgcaaat gggagcgcac tgttaattaa tgtggcataa cgggctgttt ttaatcgatc 1978501 tgcaggatgc acgaaactgt tatgatattg aatgcgccgg tcatggagat acttgtgaat 1978561 caccgcagtt gtttctgcat tcgaatgatc atccatgata aaaagctccc aaagatcatg 1978621 cgtttgctgt atcacgcttt cgatcgcttt ttgcaaataa tcgggtttgt tgtaacttgt 1978681 taaaataata gacactttct ctcccatcta taccgcctcc cgccgtcaaa cataaaaacg 1978741 gctccgcagc aagcagagcc tctgtcatca tttaaaaagc accccagctt acaacacttg 1978801 agagtgaaac atgagatctc gtgttattta acgggttttg gaaaataacc aaatcagtca 1978861 gaacttcttt tacgatgaca ttttgaagtg tatctccgtt gatcaaattg acttttgaaa 1978921 ccggtacgcc cagctctttt gcaaaaacaa gctggcgtct gaggtcagat ggatttcctt 1978981 cagaagacga ttgacgtatc agcagaatca gcaaaagcaa aataaaatgc agatcatctt 1979041 ggttttcttc tcgatccact tgtttctcta aatccaaatc atccctctcc cttatcctta 1979101 tctctgtttc acaatatgtg cgacttcgat ttatggtata ggctatgtcc actccattaa 1979161 aaaatcagca ttttccttaa atagatgaaa aatagatcag gtacggcgtt cgactcatac 1979221 caaataacag ccggaagaat atgaataacg tgagttcact atcgaatagg aggtgtgtgt 1979281 aatgagctct gaaaatgcac agttaaaaaa ggatttaatt aaagccgttt taagcccttt 1979341 atttccaact gcaacagaag gaggagaaaa tatggatagt aatcttaaag ccttgcttga 1979401 tgctgccatc gatcaaaaag tagatgaaag tgaaacggtt acggcagaat ctattttaga 1979461 cccttctctt ccggcaagat ggatttttgc cagaattacg ccaggcacta caatcagcat 1979521 tgtgactgat tcaggtgaca tgatcggacc ggttgttttc gttgctttcg atcaggttca 1979581 cgggatcgta tttgtaacac aggaaagctc cgtcactccg gcaggccaag ctacaacatt 1979641 aattgatgta gacaaagtag aaagcgttac gttcttttca taacatccga tgaaagtctt 1979701 gtatatccag tcgggatacg gaggaatata cagttatttt gatcgctggg ctgaagaatg 1979761 ttttcagaac actcatacag agtatatgat tgcagataaa cctgaagcag aatctttgat 1979821 gaagatcgaa gcgtttcagc cggatttcac acttatgatg gttggagacc gcgttcctca 1979881 cgactggctg acctggttaa agggtaagga tatccccgtg tatgtttggc tgaccgaaga 1979941 cccattttat atggatatca gccttcaggt aattaagctt gctgacgcca tattaacgat 1980001 agaacaaaat gcagctctct actatcaaga gctcggctac cagaacgtct attatgttcc 1980061 gataccagtt aaccatcggc tgtttaaaaa aatgggcacc gaacattcct atcattcaaa 1980121 tctgttaatc atcggctatc cttaccctaa tcgggttcag cttatgaaag aagcggtcca 1980181 tctgccattc acggttcggg taatcggcaa ggaatgggga aaatatctgc ctaaaaaagt 1980241 gctcaaacag ccgcatattg atgtcgtcag cacatgggtt ccacccgaac aggccgttca 1980301 ttattataat ggggcagaca tcgtaattaa tgcgcatcgt ccctatcatt ttgctttcaa 1980361 ccaaaatact atgcgcatca aaaatgccag ttttaataac cgaacgtttg atatcgctgc 1980421 atgcgaagca tttcaattaa cagatttacc cgcggcgcat cctttttcat ccattatttc 1980481 ttatcacggc atgaacgact ttaaggaaaa agccgctttc tatatcaacc accctgaaga 1980541 acggcaaaaa gctgcagcag ccaattataa agagaccgta cccgcattta cgtttgatga 1980601 gcttcctgca aaactaaaag cgattcatct ggcgctttct tgaaaaatcg ttcattgcta 1980661 tgaacgattt ttttattcat agaaaaaagc agctgcacaa gctgctttct attctagccg 1980721 tcagaacggt ctttcagctt cctcggattt acctgtttat gaagatcagg catttcgccg 1980781 agatgctgtg caatttgttc ccacgataca attttgaaat tttgattgac ggcttgtccg 1980841 ttatcaatat tttcgccgtc ctgcgccaca aaaatcccgt acggatattt tgggccaagt 1980901 ccgaaaccga gaacatcaat accatccgtg tcactagtac cgtctatctt ctcgccatct 1980961 gtaatctcaa agttggctac atagcgattt ttcccctgcc gttcatacat tgcatagctg 1981021 ttatttcctt gacttgaagc catgagatat cctttgccat ttggtgcata atagattgtc 1981081 agtccttcaa tatcagctgt caaatgatct cctgtcgcac ggtcaacaac ctgccccttt 1981141 gaccctccgc cgggctcagc gttaaatttc cagatggcct catcttcctc tgctatgtat 1981201 aggtttccgt actcatcatc cgcaacaagg ccttcggtct gagaattcaa cttaaattca 1981261 cgcacctttt tccctgttac ataacccttt ccaccatcaa caatttcata ctgctcaaat 1981321 tccccttgtt tgcctgtcac taatgcgtaa aatgctcctg ttttctggct gtgatacaag 1981381 ctgaatccat aaacctcaga aatattggtg gaaataggat ggttcggatc tgtaatgctt 1981441 ttcaattttc ctttatcccc gtctattgca tatacttcaa ttgtattttt tccttcggac 1981501 cggttggatg cggcagcaat atcaattttt tcgccgttca atggaaaatc atagcgcaga 1981561 tcgacattat tgagcttgcc aaactcataa gaatgaagct gttttccgtc taaatcatac 1981621 acaacgagcc ctgacttctt atttgttgta atcaacttgc ttttttccgg gtgtttttca 1981681 tgaacccaaa tggccgggtc atctgctgca tcatcgccag atgcgaccgg atctgtctcc 1981741 gtgtgtgcag tcactttgaa atgatgttcc tcattcacat aatgagccga caccgaggtt 1981801 gctgtcaggc taagcaataa acccgcggca gtgcttagca gcattgtttt tggaaccttc 1981861 atttggtacc ctcctctttt atcactaaca ctactattgt aaaatatata caggtgatta 1981921 ccgtgaggaa aatgaacctt tttttatagg gtttctgact cataaacaac ttattcccca 1981981 aagaggtggt gagatgactt tgccagattt acttttgcgg agcgaaataa aaatatgttg 1982041 aatatttagt acattattta tttagttttg tttttcccta gttacgtccg tttttccatt 1982101 ttctattaaa aaagaacact ttgtgacatg atcattcccc taaattttgt tttattggtt 1982161 gctttcatta attcgattac aaagttgaac atatgatgca tggtagagaa acgagagttg 1982221 gaggataagc catgcctaaa cagcaaacag cagaactaaa accatttttc cataacaaaa 1982281 cagttttagt cactggcgga acgggttcaa tcgggagtca aattgtcaaa cgccttttga 1982341 tgcttacacc taaacaggtg attgtattca gcaaagacga cagtaaacag tatgtcatga 1982401 gccaaaagta tgcggaggat aagcggctat tatttgtact tggagatgta cgcgatcaca 1982461 gaagggtgaa tcaggtgatg aaaggcgtcg atatcgtctt tcacgcggct gcgctgaaac 1982521 aggttccgac atgtgaggac catccatttg aagcgatcca gaccaatctc atcggcggac 1982581 aaaatgtggt ggaagctgcc ctttcacacc gagtgcagca tgtcattaat atcagtacag 1982641 ataaagctgt atctcctgtg aacacaatgg gtgccaccaa gctgttatct gaaaagctgt 1982701 ttcatcaagc aaaccgccac gtccaaaaca aaggaacctt gttttgttcg gtccgctttg 1982761 gaaatgttct cggttccaga ggttcggtca tccccatatt atttgaacag atgatggagg 1982821 gtgaacctct gaccatcaca gacaaaaaca tgaccagatt tttcatgtca atagacgatg 1982881 cagctacatt gacattacaa tcggctgcta ttacaaaagg cggagaaacc tttattttca 1982941 aaatggaatc actgaaactt gaagaactga ttcatgggtt tgaagaatat gcatcgcagc 1983001 acgggctccc gcggccggct gcagtagaag tgggcaagcg tccaggtgaa aagcttcacg 1983061 aagaattaac atctccacat gaaattgaat cactgtatga atggggcaac ctttatgcga 1983121 tccttccaga gccggaaaaa catcctgact ttcgcaaagt caatctgcct gggtatcaat 1983181 cagatcaagc cccgctcatt acgaaagaaa gaattgctca gattattgaa gaattgcatc 1983241 aagagaaaaa ggcataaaaa caagcctgtc tatccattag gcaggcctgt ttttaacagt 1983301 ttatttatta aagagatgca gatagctttc gtatccttct tcttttagct tatgcttcgg 1983361 aacaaaccgc agcgctgctg aatttatgca gtaacgaagt ccgtttggcc ccggtccgtc 1983421 attaaatacg tggccaagat gagaatcagc agttcggctt cttacttctg tgcgaatcat 1983481 gccgtggctc gtgtccagtt tttcttccac ttcttcttca atcggctttg taaagcttgg 1983541 ccagccgcat tgggaatcaa atttatcttt ggatgtaaac aatggcttgc ctgacacaat 1983601 gtctacatac aacccttctt ccttatgatc ccaatattca ttttgaaatg gcggctccgt 1983661 gccgttattt tgcgttactt catattgcat gcgatttaat gactttattt tttcttcttt 1983721 attgtacgcc atttatttag ccccccaatg ctcgctgata aatcccgctc gtccggaacc 1983781 tgtccggtag cgctgataat gtgctggatt ctttttataa aaatgctgat ggtagccttc 1983841 cgcttcatag aaaggttcag cttttaaaat gtccgttaca atcggatctt taaagatgcc 1983901 gctttccgcc agacgttgct tggaagcttc cgcaagctcc ttttgtttat cattatgata 1983961 aaaaatggct gcgcgatagg aactgccgcg atcagcaaat tgccctccgg catctgtcgg 1984021 atcgatttgc tgccaaaata attcaagcag tttttcataa gggaatacat caggatgaaa 1984081 cgtgatttga acggcttcac gatgtcccgt cgtttcactg cacacctctt cgtacgtagg 1984141 gttttcagta tggccgcctg tatacccgga caccactttt tcaattcccg gctgttcgtc 1984201 aaaaggttta accatacacc aaaaacagcc tcctgcaaat gtggcgattt cttttttttc 1984261 agacatactg gtgcctcctt tgttaatacg tggtattatt atattatagc atgtaaaaat 1984321 agaatgaaaa tgattctgct tttcaataaa atctataggt tttaagcaat atgcttatgt 1984381 aatggaggtt cacaaatttg aaagtaagaa cacagatgat gtacgatatg gaaactttac 1984441 tccgtaaagt ctttaaacaa atacgcaatg aaatcaatga aattttagat aaagagctgt 1984501 cgcggaatga attcaccatt cttcgaatcc ttagtgaaca agggcctaaa aaagtcactg 1984561 aatttgcgcc tattttagag gtatcggcaa gccacattac ggctgtgacc gatgcgctgg 1984621 tagaaaagga atggattacg agaatcagat cgaaggaaga cagacgcatc atccgcattc 1984681 atatcactga agcgggcgaa aaagtccttc agcactttaa cgagaaaaaa acggaatatt 1984741 tctttaaacg ctttgactgc tacactgatg ctgaacttgc cacgttaatc gagctcttca 1984801 gcaaacttga taaaaaacgg tgaaaaaaag cacataccga tatataggta tgtgcttttc 1984861 gcagtgcttc acttattttt cagtaaacag cttcattgct ttccagcggc catatctata 1984921 atacaaaaat gccgcgcagc tgctaaataa aaaactcatt ccgattccaa gcccgattcc 1984981 tttttgtcca agccaagctg aaaatagagc tgtgaaagga tacctcaaca cccaaaacga 1985041 gatcaaattt aataccagaa cctgcagcat cgctcccgcg gccctgacga ttccgttcag 1985101 cacaaaatta accccaataa aagggtagaa aaacgcgatc cacttcaaat attgttcacc 1985161 aaatgcgacc gcatcaggct cactgataaa taaccttatg aggtatttac caaataccca 1985221 aatcataacc gcaatcacca gcatgcagga aataacagct atcacaccta gccttgcaat 1985281 tgttcccact cttttttcgt ttccgattcc aatattttgc cctgccatac tattgacggc 1985341 cgtaccggca gccattgctg gaagcgtgat gatgctatca agccgctgca ccgcgccaaa 1985401 gcctgatacc acgtgatccc cgtatgagtt aacaacactc ataatcgcca tcataccgcc 1985461 tgtaatcacc atcatctgca gacctgccgg aatcccgagt ttcaaaatca gcgcggactc 1985521 ttcccacttg ggcattctcg gaatcgagaa tggcacaagc ttgtgtttga tgacataaaa 1985581 caacccatac aaaaacgcaa tgccctgtga caaaatcgtt gaataagccg ctcccgctat 1985641 tcccatgcgg aacacagaaa taaagagcgg cgcaagcact gtattcagta caacagcaaa 1985701 cgcaataaac cggagaggtg tcttgctgtc gcccagcgca cgaagcacag tactgataaa 1985761 gttataacca aacaaaaata aaatgccgat aaattgaatc tgtaaatacg tctcagcaag 1985821 cggtatcatt gactccggcg tttttagaag acgcagcaaa agctctgaga gaaaaaaacc 1985881 ggccgcgccg aatccgatgc ttaggcctgt taataaaaca acaaaagcgt taatatacga 1985941 cgccattcct tttatatcat cttttccttt ttgctgagat aaaatggtta acgtcgcatt 1986001 gttaaggccc aaaataaaag acagcacggt caaaacaatc gtgcttgata ccgcggctgc 1986061 cccaagggcc tttgccccca gtaaattgcc gatccacaag ctgtctataa attgaaagga 1986121 aacctgcaat gcgtttccga gcataatagg cattgaaaac agtacaagct gtttcagcac 1986181 gttcccctgt gtaaaatcgt atgctttcat cttttctcct tgtgttctca aattttcttc 1986241 ggaccacacg aaaaaagaga cgttgtttca tgtctctttt ttcatgactt atcggttttt 1986301 tttcggtctc gcataccgaa tgtaaacacc atcacactta ggaacaaggc acaataggaa 1986361 acattcaaat acatttgatc catatcttca gcagccagat gatgataagc aagccagccg 1986421 aagtacaggg aaaatgtaaa ggataataaa ctgaaatact ggtaaatccg tttcattttc 1986481 agtcacctct attgtttagg atggtaatag gaaaactcaa tttcatcttt ttctaaattt 1986541 atcttatccg ctttgacata cattccattc gttaaaggca tttctgacaa acgcacttca 1986601 atgcttttat ctccggggtg aacatggaca aatgacggca attcataaaa gctgtccata 1986661 taatttaaca caaagctaat tggtatactc aatttcccta acgaaaattt cgtgacattc 1986721 agctctacat caccgttttt tttcacggtc ggctcaaaag cgataaacgc atcaatagac 1986781 gtggaaaatg ccttgatttt ccctgcgaca tgaacatcat catcaatctc tactttataa 1986841 tcaagcttgt ttgatgcttt gtcgtttaaa tatgagttaa caaacgcagc taatgattct 1986901 tttgtgcttg tcacttgaaa tccatactcg ctctcagatg catctttcac ctgagcctgt 1986961 tcccccggaa gcaaaacaag tgccacaaac ccggcggcga ggataaaatt gattgcaagc 1987021 aatataaaaa acagtcgctt ccacttattc atgctgtcac cctactcttt cggtaatcct 1987081 tcttttttaa tggcttgata gacgcgcttt gcgataagag aataacccgt accattagga 1987141 tgaaaatcat cttcctcaga aattcggctg ctgtcacttt tttgattaaa caaatcttcg 1987201 atatggacga tttttgcatg tttatctttt ttcagctctt tttcagcaat atggttccaa 1987261 tccgtgacga caccatttat ttcatttagt tctgataatg taaacgtaaa cggattgtac 1987321 atgctgacat aaatcagctc agcgtgatca ttcagctcgc gaatttcaga aatgattttt 1987381 tcaaagcgct tttcgtacgg tttttccgct tcctgaaacg gttcaacggt taattgcaga 1987441 aagttttggc gaaggatttt catcaaatca ttaccgccaa ttgtaaaaaa gacataatct 1987501 gcgtccttta tgcctttttg aaccttttta tcttttagtt tttctaataa atcatccgaa 1987561 cggttccctt ttacagcata atttttcacg tcgaccgttt tgacttgttt atctgaccgg 1987621 atagaatccg ccaccttgcc gacatatccc tttccgtcgg gatctccgac tccttctgtc 1987681 agcgaatctc cgacagccgc tatgacaatg tgttcttttg ttttcgtttc atgggctttt 1987741 tgttttccct cagatgatgt acgtatgctc gtacacgcag taagaagcaa aatcaaactg 1987801 gccatgattg aaaaaatgcg cagcttcaat cttgttgctc cttcccattc tactagtgga 1987861 aagtgtatca tgttttagaa gatttgcaaa tgcctagtct cttagcttac ttgagtgtac 1987921 tggctgactt cacatcggaa atgatatcat cgtacggtgt attctccact ccattgtaat 1987981 ctttcagcac cttaccgtcc ggacctacca aataaaaaga agattgatga atcacttggt 1988041 cctctccctc cggcttcttt acgatcgctt taaagctctt aagtgcgaac tcctcaatct 1988101 cactctggct gtatcccgtg agaaaatccc agttatcaaa agataatgga taatttgcgg 1988161 caaatttctt cagctgtttc ggcttatcgt tttctggatc aacactaaat gatatgatgc 1988221 ggacatctat attttcggct ttcagttttt tttgcagatc ggtcatatga gcggtcattg 1988281 gcggacatat agtttcacaa ttggtaaaaa taaaatccgc cagccatact tctcctttta 1988341 aactctctaa agaaacgttc ttgccgtctt ggttttgaaa tgtaaaaggc tccacctcgt 1988401 aattgagcgg atctttaatc tgctgtcctc cgcatgcaca caaaaacaga aaaatcagcc 1988461 cagccgttaa ccccttgata accttcatga catccatcct ttccagccag cataaaaacg 1988521 ctttctaaaa ccgtccttac tgtcccatgt ttgtattcga tactgagcaa aaaaaatcct 1988581 gcatgcctcc ccattaacga ttacaaagga gggcatgcag gtaaaaaacg gcatgttacg 1988641 cgttgtgctt taacacctct tgatgaaata cagcctgata atctgcccac ttcatccgcc 1988701 gcttcatata atgtcggaaa gaatacactt ttgccctgct gtttgatgaa aacacttctt 1988761 ttaagtagaa ttgcaaatgg tgatgtaaca taaagaaata gtgctcatct tcctttaata 1988821 caggtatttc tgtcactttc acctgaatcc cgtcaccgcg tttgaactct aggcttttga 1988881 gtaacaagct atcaatcctc ttttttgttt ttcttctatt atatatgatg ccagccgggc 1988941 tgtctgtcat tttgcgcggt tgtgtaaaaa aattagatta gcaaatggaa caagtcctca 1989001 tccttgttca cctctacata atgaaacggt tttttgttca tccgttcaat cagcggccca 1989061 taatcggctt tgttctgcag ctcgatgccg acaagagcag gtccattgct tttattattt 1989121 ttcttcgtat attcaaacct tgtaatgtca tcattcggcc cgaggacttc gtcaagaaat 1989181 tcgcggagcg cccccgctct ttgtggaaaa ttgacgataa aataatgctg aaggccttca 1989241 aaaatcaagg aacgctcctt catttcctgc attcttccga tatcgttatt gcccccgctt 1989301 accacacaca ccacgttttt ccctttaatt tgatccttgt acaaatcaag cgctgcgaca 1989361 gaaagagctc cagccggttc agcaacaacc gcacattcgt tatataattc aagaatggat 1989421 gtacatactt ttccttcagg cacaaggaga atgtcatcaa cgacagtttc cagcgtccgg 1989481 aaggtttcct cgccaatttt tttaacagcc gccccatcta caaacttatc aattttatca 1989541 agtgtgacga catgcccagc tttgtttgat tcaaagtagg atgccgctcc cgccggctca 1989601 acagcaatta cctttgtatc aggagacacg tttttcaaat atgtacctac cccagagaga 1989661 aggccgccgc ctccgacact tgcaaaaaga aaatgcggtt ctgtatcaat gtcgtttaaa 1989721 atctcgactg cgagcgttcc ctgtccggcc atcacatccg gatcatcgaa cggatggata 1989781 aacgtccgag attccgcctc acagcattca gcagcgcttt tatacgcgtc gtcaaacgta 1989841 tcgcctgtca aaataatatc gataaatcct tttccgaata gttcaacttg agatactttt 1989901 tgtctcggtg tagtagacgg cataaaaatt ttcccgtgaa tgccaagatg tttacacgaa 1989961 aatgccacac cttgagcgtg gtttccggca cttgcacaca caactccgtt ctctgtctgc 1990021 tcgctggaaa gctgtttcat tttatgataa gcccctctga gcttaaaaga tctgacaact 1990081 tgcaagtctt cgcgttttaa atagatattg cattcatatc tctcagaaag tctgtcattc 1990141 ctctgcaaag gtgtgtgaat gacaacgtcc tttacgtttt ggtgagcctt caaaatgtct 1990201 ttcacttgga tgagagagtt ttctttaagc aacggtttca tgtacagatt cctttcttgt 1990261 tttaaatccc tatttaatat gccattataa catgaatatt caaaaaataa gacaattatt 1990321 tttatttaat aattaaaaaa atacagacta tgtccaccac atcttgtggt aacttctgtt 1990381 caaccattat cctgcagagc caagaaaaaa gatgatcgta aaataaaggg tgttttcaac 1990441 caaaaggcat gatataatga aaccaattag aaccaaaagg agccaattga tgaatagtgc 1990501 accaaaactc aatacatttc aacatctaat cggagaacat caaacttttc tggaagcgaa 1990561 gcgaatcgcc aagcagttct cgttatcgga gcttcctgtc ttaataacag gaaaaatcgg 1990621 aacaggcaaa aatcacttcg cacatgccat acacttggaa tcttcgagaa gcaatgaacc 1990681 gtttataagc gtcaattgca gcacccattc ggaagaaacc cttattcatg agctttttgg 1990741 ccctaacgga aacacaggtg tttttcaaaa agcggtacga ggaacccttt ttcttgatga 1990801 tgtatggcgc atgcctgctt ctgtacaagc tcagctgtta aaagcgcttg attcagacac 1990861 ggagaaaccg cgaatgatct gtgcttctgc agaccgatcc gtggaacata cattcaggca 1990921 agacttattc tacagactga acattttaac gctcacactg cccgaattat cggaacgaaa 1990981 aagcgatatt ccgcttttga cacagcattt tctctcaaat tctggtcagc aattgttaat 1991041 cgatccctcc gtttttcccg tgcttgagaa gcatgcattt gaaggcaatg tcagggaatt 1991101 aaaaaacgct gcagattata tggcggcagt atcaagcggg ggaacgattc agccatatga 1991161 cctgccgccg tatattagag gcacgataga cggaaaaacg tcgaagaaaa aagcgaaact 1991221 gcttacttta atggaaaaag ctgagttttt gtttattttg gaaacaataa aagtattgaa 1991281 cgaaaaagga gaacctgcca gcagacggat catttctgaa cacagcaaaa atacccaaac 1991341 ctcgttaact cctcagcagg tcagaagccg tctcgactat ttggagaaaa aagattatgt 1991401 caccaaaagc cgcggacgcg caggcacaaa aattaccttt gagggcttga gctttataga 1991461 gacgttaaaa aatcaaatga tctagcgatc gaaaggagaa tgtacttgtt tacaatcaaa 1991521 gaagagatcg ccaatgcgat tacacacggc atcggtgtcc tcttatccat cccagcatta 1991581 gtgtttctaa tcatatttgc ggctaattac gggtctgcat gggacattgt cagctttaca 1991641 atattcggtg tctctatgct gctgttatat ttgagctcca ccctgcttca cagcatcaca 1991701 cataaaaaaa cgaaggacat tttggagatt attgatcata gcgcaattta cgtactcatc 1991761 gccggaacct acacgccttt tttgcttggg ccgctgaaag gcacactcgg ctttaccctg 1991821 ttggttatcg tatggtcact tgccctaggc ggaatcgttt ttaaaatttt ctttgtgaaa 1991881 cggtttatcc tattgtcaac cttcgtgtat ttagtcatgg ggtggctgat gattattgca 1991941 gttaaacctt tatatgcttc actgagcgga gcgggattca gcctcctttt tctcggcggc 1992001 attttatact ctgtcggaac catcttttac atttggaaaa agatcccctt ccatcacgcc 1992061 atttggcaca gctttgtatt gggcgggagc gctgccatgt ttttctgcgt gctcttctat 1992121 tgtgtaaagg tgcctttcct ttcgtaacag taacagaaaa gcgcagtctt cacgactgcg 1992181 cttttttatg cacgtaattg tttttcattg gcaggtatat aagcttttga aaaggacaat 1992241 tcaatgtctg ccggttttaa gcgtttaaaa aacgagccat tttgcatgtt atctgttcct 1992301 ttcgtttcca ccatcaccaa cggaagatga tagcgggccg caagttctac aggatcaata 1992361 gaaccatcta gtgaaagaat caggctttgt cccttttcca gctgttttgt cacatcttca 1992421 tatacctttt ctgaatcccc gtctgaaatc acatccatcc gatccagcca ttgcccgata 1992481 aaaggcaagc ggaacacttt tgggttagcg ataaagccgg ccggttcctc aatatatcca 1992541 gcaattaagg ccagttcagc caaacgcaaa cggggatgca catacaaaac aggaccgtgt 1992601 ggtattggct ctggctgatg gatcgtcaca actgaaccgg agatgccgat acagccttct 1992661 aaaaacgcct ttggctgttc gtacacaaga gccatctgtt ttttgtatga cagacgggga 1992721 tcgagcattg tttgattaaa taattgtttc atatttttta acagcatata cacaatataa 1992781 accactagaa ggctgtagcg aaccaattaa aatcctcccg ctttagaaga attctttttt 1992841 tcatacatta gaaattcgta atcatacggg tttttttcgt ctttggtccc ctgctcagaa 1992901 gaaaccagct tccaattgga ttcatcaaat tcaggaaagt gacggtcacc ctcaaactcg 1992961 tgatgaattt tcgtcatata cagtctgtcc gcataaggga acaggtccgt atagagctga 1993021 gcccctccga tcacaaagca ttcttcaggg cctgaacaaa tgtccagtac atcctttaat 1993081 gaactgacaa ccgtgcatcc ctgaaattct gaatccggcg ctgaggtaac gacaatattt 1993141 ttccgatttg gaagcggacg tccgatcgat tcaaatgttt tccggcccat aatgattgaa 1993201 tggcccgatg ttattttctt aaagtatgca agatcattgg gcaaatgcca cggcaaatca 1993261 ttgtctttgc cgataagcct gttggcatcc atcgcaaaaa tgaatgaaat catacgctga 1993321 ccgccccttt tatatgagga tgcggatcat aatcctcgat gataaagtcc tcaaatgcaa 1993381 agttaaaaat agaatcaacc tttctggcga aacgaagctg cggaagcggt ctaacatctc 1993441 tttccagctg caaattgact tgttcaatat gattttggta aatatgaaca tcaccaaacg 1993501 tatggatgaa ctcgcccggt tcaagcccag tcacatgagc aatgatcatg gttaggaggg 1993561 cataagatgc aatattaaac ggcacaccta agaaaacatc ggcagagcgc tgatacagct 1993621 gacaggacag cttgccgtca gacacataga attggaacag gcaatggcac ggcggcaacg 1993681 ccattttatc aatttcacca acattccagg cgctgacgat taagcgtctg gagttcggat 1993741 ttgttttaat atcttcaata agacgggaaa tttgatcaat ggtttctcca tcagctcccc 1993801 gccaagaacg ccattgggag ccatatacag gtccaagttc accgttttca tcagcccact 1993861 cattccagat tcgcactccg ttttcctgca gatagcgtac attcgtatct ccttttaaga 1993921 accacagcag ttcatgcgca attgatttaa agtggagttt tttagtggtg agcatcggaa 1993981 agccttcccg taaattaaat ctcatttgat atccgaaagt gctgattgtt ccggtcccag 1994041 tccggtctcc ctttttctca ccatgctcta aaacatgtct gcagaaatcc ttatactgtt 1994101 tcattttttt catcctttaa aagtagtctt ctagtagtgt aacacaataa aaaatcattt 1994161 ctgaacccag aaatgatttt tttatagtca gctgacgaca ggcttttcat cctgttcttt 1994221 ttcttcatct tgcagatcct gatgcgtatg tgcaattctg ctcgccgctg ctgcagcaag 1994281 agctgccaca atatcatcca aaaaggtgtg aataccgtct ggactttcat caagttcctt 1994341 aataattcca atcttctctt tatccaaata accgaaattg gtcaaaccga tcgacccgta 1994401 cacattaacg attgaaagcg ggataatttc atctatgccg taaagcggtt catccgtttc 1994461 aacaaggtgc tgcagcggtt cggggagaag tttctgttct gcaagctgat cgagtgcaag 1994521 gcctgtcaaa acagcatgaa taatttcacg tttgttcagg actttttcta cattctccat 1994581 gcaaacactg agcggcagat ttggattgta tttttcctga agtttttgaa caatccgtgc 1994641 aatatcttct atcataacgc cccgtttgtt cagcatatcc tttgttatat cgaccatttc 1994701 attcattgtg tactttttca tgtctaatgg catctccttt aggcactcat ccagttggga 1994761 ggcgtgttgc ggtcccagta aatgctccca agctcatgat gtgattgaaa tccatcttct 1994821 gctgtatgat aatgaaaatt aaaccagtag ccgtcatgag gcgggtggtc tcttcgcaca 1994881 tggaatctga gaagatcttc tccagttgtc cgattgtaaa cgttgaaaat tttttccgtt 1994941 ttgcccgctg aaggcatgct tgagatcaca acatcttggt acgcctcatc atcttgcaat 1995001 gtcgctaaat aatcactaat cacattttcg atttttggca ggatctcttt ccgatagtca 1995061 tcctcaatga caggagcgat tctgctgccg aattttaaaa aggactgatc ctcagcgctg 1995121 tcaaggagct gttccttgta cgattgaaaa agcagttcag gatctcgcct gtcatccgac 1995181 tcatcatcgt acaggtcatg ctcatcataa aaagcggtgt aatcattctg ctcaagactg 1995241 ctcggctgtc cggaaggctt gtccgccata agggcagccg gaggagatac gagcccgaac 1995301 gttacaatgg taaataaaac cacaagggtc tttctcatcc acaatttcat gactgcttat 1995361 tcctctctat tttattgtca tgtttctctt attttagcac atccaaaaca tgcaagtcat 1995421 gtactatatg aaactgatat gcaaattagg agattcgttg ctatgcactt tgtgtaaaaa 1995481 cgcttacaat atttcatgaa aggaggcttt ccgcatgatt gacgctctgt ttgccacagt 1995541 ttcactctta acattattat actttgtcgt catggaggtc accgattaac agaaagcccg 1995601 tgatatgaat cacgggcttg tttgaatgac gccataatgg aacagtgctg tttttctttt 1995661 catgacgtta aaaccaaact gttcaaaccg cgggcttttc cagtggtctt ttagcacaac 1995721 gctttttctg gcgactcgta ccgcttcatt gatacatcct tcgtgcaaaa cggaatcctc 1995781 tgccaaatca cgtaaaggcg cgatgccgtc agaggtttct acaggttcat gaaacattgg 1995841 atcgaaataa accacatcaa cagagttgtc agggagctgc ttgatgtgtt caaagcaatc 1995901 accattcttc acctggattc ttctcatcgc agcttgaagc tcttctatac ccgtttccca 1995961 tgaatgcagc cccgtcctca ctaaaacaga cacaagatgg tttttttcaa tcccaacaac 1996021 agaacccgtt tcgcctactg ccatacttgc gataatggca tctgacccca acccgagtgt 1996081 gcaatctaaa aacgtatccc cttcagataa gccggcagcc cgaagcatag gttctttctc 1996141 cccctgtaag aagcgtttgg ctctgaacat cgctgtattc ggatgaaaaa agaatttggc 1996201 accttgtttc gtatacagct caaaccgctc tttgccgacc acaagcaaat cacgttcagc 1996261 tgatttcagc aggtgctcaa ccgtttgttt attccggccg cagtatggca tatttagctc 1996321 tttagaaagc tgctttgcag tttttatggt gtgttcagac ggtctatagc ttgttgttat 1996381 catcttctgt actcccaaaa agaaaatgcc cggagaacgg gcatttagca gtgcgcatcg 1996441 aaggcagcag tcagattttt catgatttct tccatatcgt gtccttcaat ttcatgacgc 1996501 ggaataaaat gtacgacttc tttgcctttc aaaagagcca ttgatggtga agaaggctcc 1996561 tggccagtaa aatactcacg cattttcgca gtagcttctt tatcttggcc cgcaaataca 1996621 gtcaccgtat tgtcaggtgt tttgtcattc tggaggactg cctgtgtagc cgcaggacgc 1996681 gcaaggcctg ccgcgcagcc gcatacagag ttaacgacta caagagttgt gccctctgcc 1996741 ttttccataa agttttctac ttcttccgct gttgttaact cttcaaaacc tgctccagtc 1996801 agctcgcggc gcatcggtac gacaagctgg cgcatgtatt cttcataagc cattgacata 1996861 aaaaaagccc cctctagtat ccttcatctg aagtaaagga tactatagag agggccggat 1996921 ttcaaatgtt cacgccttaa aataaaagaa agtgtcccca gctatctaga ttttcataat 1996981 accgccggtg ttggcacttg tcacaagttt agaataacgt gccaggtagc cggttttcac 1997041 tttcggttca aaacctttcc agttcgcttt tcgtttttcc cactcttctt ctggcacttg 1997101 tacatccaag atgcgttttt caatatcaac gataatatgg tctccgtttt caacaaaggc 1997161 aagcggcccg ccctcagcgg cctcaggtga tacgtggccg attgagaggc cacgggaggc 1997221 tccggaaaaa cgtccgtccg taatcaatgc cacttttggc ccgagtccca ttccaacgat 1997281 ttgggatgtt ggcgccagca tttccggcat gccaggtccg ccttttggcc cttcgtatct 1997341 gatgatgaca acgtcgcctt cttttacttt tcggttgata atgccgtcaa gcgcctcgtc 1997401 ctgagaatcg aatacgacag ccggcccttc gtgtcttgta atcccattct gtacgccgcc 1997461 tgttttaatg atagcgccgt ccggagctag attaccgaat aaaacagcaa ggcctccctt 1997521 ttcagtgaat ggttgatcca gcgggtgaat gacgtcataa tcctttactt catgtccggc 1997581 aatggtttct ccaagagttt ttcctgtaac agtcagcgca tctaaatgaa gcgctccttc 1997641 tttcttcgaa agctcattca gagccgctga aacgccgccc gcttcgtgaa gatcttcaat 1997701 aaacacatcc gatgcaggcg ccagcttagc caagtgcggc acgcgctcag cgacttcgtt 1997761 aatgcgttct aaagagtatt caacgccggc ttcgtttgca agggcaaggg tatgaagaac 1997821 ggtatttgta gaacctccga gcgccatatc gagtgcaaac gcgttatcaa tcgcttttac 1997881 tgtaacaata tcacgcggtt tgatatcttt gcgaatcgtt tccattaatt gcgcagccga 1997941 ttttctcaca aactctttgc gttccggaga tgttgccaga atggttccat tacccggcaa 1998001 agcaagacca agtgcttctg acagacagtt cattgagttc gccgtaaaca tgcctgagca 1998061 agacccgcac gttgggcatc cgaactgctc tagttcttga agctcgtttt cgttgatttt 1998121 ccctgcttgg taggcgccta ccccttcgaa tactgaggaa agggagattt ttcgcccgtc 1998181 acttgttctt cctgccgcca tcggtccgcc gctgacaaaa atcgtcggaa tgttgatgcg 1998241 cattgccgcc ataagcattc ccggtgtgat tttgtcgcag ttcggaatac agaccattcc 1998301 gtcaaaccag tgtgcggata caaccgtttc cacagagtct gcgataattt cacggcttgg 1998361 cagcgaatat ctcataccga tatgccccat tgcgatgcca tcatctaccc caatggtatt 1998421 aaattcaaac ggaacgcccc ctgcttctct gattgcttct tttacgattt tcccaaactc 1998481 ctgcaagtga acatgaccgg gaacgatatc aatgtatgaa ttacacaccg caataaacgg 1998541 cttgccgaaa tcctcttctt ttacccctgc tgcacgaagc aaactgcggt gcggagctct 1998601 atcgattcct tgtgtgatca tattactgcg taattctgcc atggtgatcc tcctaaattc 1998661 tttcaattgt ttgattggat tttattttga caattttcag tttatttatg ggctgttttt 1998721 gcaaataaga taaatacagg ccgccctcac cttgttttgt tctttcgtgt ttttatattt 1998781 atatagcttt ctttcgattt gaaccctcca actattaata ttgttactta ctataaatag 1998841 ttttcggata tttttcaaca atattcgaaa taatttttat aaaaagtgaa ttcacataaa 1998901 aaaggtgcat gatctgcacc ttttttatct ttattcgcct ttttttctgc tttccgtcat 1998961 ttgtttccaa acagaacctt ttgcttcttc tccatgctca atacgttcaa gcgccatttt 1999021 gacttgaagg ctgacctcaa attcggggtc atcttcggca gcgcgcaaag cttcaattgc 1999081 actttcatcg ccgacttcgt acaggaacat ggcggcacgc cagcgaacaa gcttgctgga 1999141 gtcgcttaat gacttgatca tagcaggaat ggcttgagga tcgccgatat cagacaggca 1999201 gtctccggcc gttcttctga ctgatacagc tttgtcctca agtgctttat acaatagagg 1999261 aagaacatca ggtgtttcaa tcattcctaa gtacacaaca gcctgtcttc tgatggacac 1999321 ctttggatca tccaatgcct tctgtaaaac cgggatatcc tcttctttcg gatccatctg 1999381 ttccaagtgt gcataacgct ttttccagtc ctcatcatcc agcatatcaa gcgttacttt 1999441 atacgctttg cgctgtacag cttgttttgc ttcgcccttt ccttgagcgg ctgcttcagt 1999501 cagtcgtttc agccgttcat cactgtatgc cgcttgaagc tcttctgtca catcatggcc 1999561 gatttcatca aagtcaccga atctgacacc ttgttctttc caagcccgct caaacacaac 1999621 attggaagct tcagatctaa gttttaagat cgcctgctga aagcgttcag gtaagccgaa 1999681 gcgttcttcc cgctctccat cggttaattt aacttgcata ggaatgccgc tgaacatctg 1999741 cacaaaaact tttacctctc caaaagattc ttgatcagaa cgattttctt ctgcgctttc 1999801 agcactttcc atcccaaatg cagtgcggac ttgcggtaaa atgtctttcc agtcgtatct 1999861 tgcattccgt tcaacagcaa gaaaatctgc gacgtgatat acccctttaa ctccatctat 1999921 tttaaggatt tccgctataa caagcggtgc gccttctgct tgctcaggtt tatagttatt 1999981 gcttttgccc gccggaagct cttccgttaa gatgactttc attgtattcg ggcttggtgt 2000041 aggttcaatt gattttatct tcatgatcgt cctcctatag catatctgtg acttattcta 2000101 tcatagtcgc tccaagcctt ctattacgac gtttcggcat caatcccggg tatgtctttt 2000161 tctaattggc ggacaaattg aagcataaaa ttgtgtcttt cttctgccag ttcccgtgca 2000221 gtgtctgtat tcatcatatc tttcagccgc agcagcttat gaaaaaaatg agcgtaggcg 2000281 ctttgctcat ctccataaag gccatgccct tttgcgcccg caaacatgaa agctctcgca 2000341 atgccgacag caccaatcgc atcaagtctg tcagcatcct gtacagcttt tccttcaatt 2000401 gagagcggct ccttcgccaa tttccccctg tcccgaaagg acatccttgt tataatatga 2000461 atcaccctgt cagcattctc ttttcctact ccgaaaaaaa cgagctgatc atatacttcg 2000521 ctcacagaaa gcctgaccgt gtcaggcagc ttcacatcaa ttaaatcatg aaccaaagcc 2000581 gccgtttcaa caatgaacaa atccgctttt tccttttctc caatatacgc tgcaagatct 2000641 gctactcttg atacatgatg ccagtcatgt ccagagcttt cgtcagtcag gatagattga 2000701 acccatgtcc tgatttgctc tgcctgcttc aattccttca caaaaacacc ctctttttat 2000761 tgctctaata gcttcacgat atcgtcttcc aactctttcg gatttgtatt tggtgaataa 2000821 cggccaacga tttctccatt tctatccact ataaatttcg tgaaattcca cttgatcgcc 2000881 ttagttccca gcatcccttt cgcatgttct gtcaaataca caaacagcgg gtgggcgttt 2000941 ttcccgttta catccacttt tgaaaacata ggaaatgtaa caccgtaatt tgtttcacaa 2001001 aattcctgta tgtcagcctc ttcaccaggc tcttggttca tgaattgatt gcaggggaac 2001061 cctaagatct ccagcccctc ctgctgatat gtatcatata attcctgcag ctgcttcaat 2001121 tgggaagtaa aaccgcactt acttgctgta ttcacgatca tcagtacctt tcccgcgaaa 2001181 ggctgaagtg tcatgtcttt ccctgtgatt gtacgtacct tcatatgata aatagacatg 2001241 taagtccctc ctatgtcctt ggtgctgatt attttacctt ttttaaatcg caattcaaaa 2001301 tgtaaacatc aattaagaac tcataagaaa cctaacgata tgagcgtcag ttcattatca 2001361 attcatatgg ctcgtttttt atcttatcat tctataaaac attacaattc cctcttacat 2001421 ctttgaaaat cattttactg tgaaaccaaa aggcgtgtca gtgcgtttta tttaaagagt 2001481 tttctgttgt ttccccctca acacgtatag atagattgaa aattggcgtg aaaattccta 2001541 taatgaagaa aattaaacgg ggaaataatg gaggtggcac gttgcctatt aatataccaa 2001601 cacacctgcc ggcaaaacag gtgcttgaaa gtgaacatat atttgtaatg gatgaaagca 2001661 gagcatttca tcaggatatc cggccgcaaa aaattattat attaaatttg atgccgaaaa 2001721 aaatccaaac agagactcag cttctcagat tgcttggaaa ttcgccttta caggttcatt 2001781 tcacattttt aatcccaagc acacacacgc cgaaaaatac tgcgagagaa caccttgacg 2001841 aattttacac gactttttcc aatatccgtc acaagaggtt tgacggcatg attatcaccg 2001901 gtgcgccgat cgagcatttg gcgtttgaag aggtttcata ttgggaagag ctcaaggaaa 2001961 tcatggagtg gagcaaaaca aatgtcactt caaccttgca tatttgctgg ggtgctcaag 2002021 caggtttgta ttaccattac ggtgtggaaa aaattcaaat gccgaaaaaa atcttcggtg 2002081 tgttcgaaca taccgttctt tcaaaacacg aaagattggt aagaggtttt gacgagctat 2002141 actacgtgcc gcattcccgg catacagata taaatatgga acagcttcaa gcagtgcccg 2002201 agttaaacat tcttaccgca tcaaaggaag ccggggtttg cttaattgtg tctaaagacg 2002261 aaaaacaagt ctttttgaca gggcaccctg aatatgatac aaatacgctt cttcaagagt 2002321 atgaaagaga tttggaacga aacctttcta ctgtcgaggc ccctaaacat tattttgcaa 2002381 aaggcagcaa cgagccagtg aatcgctgga aagcgcatgc cacattattg tttatgaatt 2002441 ggctgaatta ttacgtttac caagaaactc cttatgaatg ggactaattt ttcttttttt 2002501 agtgatacgc tgagcaaaaa atatgataaa atacatctga ttcagtctgc gtataacaaa 2002561 aatttaaaat actggaatcc aaatcattta aaattagctt aactttttca ctgcattaat 2002621 aattcgatta tgtatttgtg ttatgtttat gtatagacaa taactcctta cgatgcatga 2002681 agcttgcttg ttgttgatta cattgaggtg aatttacttg aataccaata aaagagtatt 2002741 aattttgact gcaaattacg gaaatggaca tgtgcaggta gccaaaacac tttatgaaca 2002801 atgtgtacgg ctcggctttc agcatgtaac agtttctaat ttgtaccaag agtcaaatcc 2002861 gattgtttca gaggtaactc aataccttta tttaaaaagc ttctcaatcg ggaaacagtt 2002921 ttatcgtttg ttttattacg gagttgacaa aatctataat aaacgtaaat tcaatattta 2002981 ctttaaaatg ggtaataaaa gattgggcga acttgtcgat gaacatcagc ccgatattat 2003041 tattaataca tttccgatga tcgtcgtgcc ggaatacaga cgccgaactg gaagagtcat 2003101 tcctaccttc aacgttatga ctgatttttg tcttcataaa atttgggttc acgaaaacgt 2003161 ggataaatat tatgtggcga cagattacgt gaaggaaaaa ctgctggaga tcggcactca 2003221 tccaagcaat gtaaaaatca caggaattcc aatcaggccg caatttgaag aatccatgcc 2003281 tgttggcccg atatataaaa agtacaatct ttcaccaaac aaaaaagtgc ttctgatcat 2003341 ggcaggtgct cacggtgtat taaagaacgt aaaagagctg tgcgaaaacc ttgtcaagga 2003401 tgaccaagtg caagtagttg tcgtgtgcgg gaaaaatacg gctttaaaag aatctttgag 2003461 tgcgcttgaa gcggaaaatg gtgacaaatt aaaagttctg ggctatgtgg agcgcattga 2003521 tgagctattt cggatcacag attgcatgat taccaagccc ggcggcatta ctttgacaga 2003581 agccacagcc attggagtgc ctgtcattct gtacaaaccc gtgcctggcc aggaaaaaga 2003641 aaatgcaaac ttctttgaag accgcggagc tgccatcgtt gtgaaccgtc atgaagagat 2003701 tctcgagtca gtcacttccc ttcttgcaga tgaagatacc ttgcatcgca tgaagaaaaa 2003761 cattaaggac cttcatttag caaactcctc tgaagtgatt ttagaggata tcctgaagga 2003821 atcagaaatg atgaccgcca aacaaaaagc caaagtgcta tcgtaatggc gtacttgaga 2003881 gcatacgaaa atcgtgtgct ctttttattt atattcagcc atcaataaaa gcggttacat 2003941 ttttttatgg aacttgccct tcttttgaaa aataagccgt ttcgcaactt gacgggtgct 2004001 cccagatggt gtatagttga accatcattt aacaatgaat caaagttaga tgatgacaaa 2004061 atttttttta gcacatgggt gctacagtac taggaggaat taagcaatat gcaaaacggt 2004121 aaagtaaaat ggttcaacaa cgaaaaagga ttcggcttca ttgaagttga aggcggagac 2004181 gatgtatttg ttcacttcac agctatcgaa ggagatggat acaaatcatt agaagaagga 2004241 caagaagttt cttttgaaat tgtcgaaggt aatcgtggac ctcaagcttc taatgttgta 2004301 aaactctaaa ctcaatacat gatgatgaga tgacaaatag aggagaggca ttcgcctctc 2004361 ctatttgatt ttcatctgga tttcaatcgc caaaatgttt tgtttacacc tctgttcaat 2004421 ctcttcaaca tacttttcca ttgatggttt tccttttttc gcgatatcgg ccagttcttc 2004481 taaatcactg tatatttcta taaatgtttt gtgaaggatc aacttcaagt ctttatcatc 2004541 catagctgcg ttccccttct ctatcaagat acctcaaata gtaaaacggt cctatttatt 2004601 ctggttcaat agttatatcg gcttattttt attttctttt ctattttggt acataaattt 2004661 caaaaaaact ctgcaaaata atggcggagg tgttttttgt gacttcagaa tttcataatg 2004721 aggatcagac cggctttacg gataagcggc agctggaact agcggtggaa acagcgcaga 2004781 aaacaacagg agccgcgacg agaggccaaa gcaaaacatt agtcgactct gcataccaag 2004841 ccattgagga tgctagagaa ctgtcacaat ctgaagagct ggcagctctc gatgatcctg 2004901 aatttgtaaa gcagcaacag cagctgctag atgacagcga gcatcagctg gatgaattca 2004961 aagaataaaa accgcagctt ctgcggtttt tatttttagt gattggttaa gacatctccg 2005021 tattgtttca acttttcacc aaccgtacat ttattgatac aaaatgaatg cgcataagtt 2005081 ttgccaaatt ctttgcgaaa ctgcttctta ataaaacagt ccttgcaata ttcatcgtgc 2005141 agttctgtca gttctttaaa gatcattttc ttatccaata tcgtcatctc cgttacggtc 2005201 taatttcgtg tggctttcta cgaattgatg ggatagaatt tttttagcga ggccgtcagc 2005261 ttcctgattg tcttttcgtt gtattgtttc gtaggttgga gtaagcttca gcgattcaag 2005321 gagtgcttct attttgtcca gccattcatt atgagatgga tcataacaag gccagctgcc 2005381 gtcaagctga ttcagcacaa caagcgagtc ccctttgatt gtaattgaat ttctgcttgc 2005441 cccaagctct cttacttctc ttattgcttc ataaagcgct gcgtattcag cttcattatt 2005501 ggttttcagc cggaagcttt tattttttct caagcgatgc cgggttcctc ccaatgaata 2005561 atagatgacg atcccgagac cggccagttc gctctcttta tcgaaactgc cgtcaaaata 2005621 aacagtaatg tcatcaggct cttgagcaag ctcctctgtc agcttttcca attccttcag 2005681 cgtccagctg ccgcctttct cgtcttcgaa ctctagctcc ttcatgtatg gaaaacggcc 2005741 aagttctctg gcgaacgtac gtgcctgctg tgctgtcagc cagtcttcgc taaaaaatga 2005801 gacggatccc gttccttttg cttctatttt caaatgcggt ctgagcttca ttacaatcac 2005861 cttaccattc attagttgcc gggcttatgc tataatcaaa ccaatcttac cccggaaagg 2005921 aagctttttc atcttgttta ataattcgtt ttggatcttt tttgcgatca ttcattttat 2005981 cattgttctt ttattttata aaggatttgg caaaatggga ctgtttgttt ggatcggttt 2006041 tgcgacagtc tgcgccaacc tccaagtcgt caaaacagtc gaactgtttg gcttaacagc 2006101 gacactcggg aatgtgatgt atggcacaat cttttttgcg acagatgtgc tgaatgaaaa 2006161 atacggacca gctgaagcca gaaaagcggt atggctcgga ttctcaacgc tcctgacgct 2006221 gacatttgtc atgcagggcg tgctgctttt cgaaccggct tccagcgaca tatcacaaac 2006281 agcgctggaa acgatcttcg gattccttcc gcgagttgcg ttaggaagtc tgcttgcctt 2006341 tatcttcagc caaacgctgg atgtttatgt atattcggca attagaagga tatttccttc 2006401 tgatcggctt ttatggctca gaaacggcgg cagtacagca gtcagccagt tgtttgatac 2006461 attcatattc actgcagtcg cctttctcgg catttatccg gcagacgtgt ggcttcatat 2006521 ttttatttct acatatttga ttaagtttgc ggtatcttta atttcattgc cttatgccta 2006581 tgcagccaaa aaaatgatac ctaatgatga aaggagttca taatgcctac agaaatatat 2006641 gtagacggcg caagcgccgg taatccaggg ccttccggta tcggcatttt tatcaaacat 2006701 gagggaaaag cagaatcttt ctctattcca atcggagtgc atacaaacca ggaagcggaa 2006761 tttcttgcat taattgaagg gatgaagcta tgtgcaacgc gcgggtatca atcagtttcc 2006821 tttcgaaccg attcagatat tgtggaacgc gccactgagc ttgaaatggt taaaaatata 2006881 acgtttcaac cgtttgtaga agagatcatc cgattaaaag cggcattccc tctttttttc 2006941 atcaaatgga taccgggcaa gcaaaaccaa aaagccgatc ttctggcaaa agaagcgatt 2007001 cggctgaatg aaaagaatta aatcttgatc attggttcat cctaatggcg aggtgaacta 2007061 acatgaaaaa gaaagataaa ggccggctga ccggcggtgt tactccgcaa ggcgacctgg 2007121 aaggcaatac acataatgac cctaaaacag agcttgagga gagagcaaaa aaaagcaata 2007181 caaaacgcta gagaggatct aaacgatctc tctagcgttc agcttttcaa gcatacgctc 2007241 aattccttta atttggtggc ggcgaagcat gtcagccgcc tgctccattt gcaaagtaaa 2007301 taaagcgtct ttcagtgtgc aggccagcgg cactgagcaa tggatttccg caagcttcct 2007361 cgacatctcc aaatcgctta aaccttgctg aatttttccc tgctgtcctt ttggaagaag 2007421 agaaagattt tccaataaac ggtcaatcgt ttcgtattca cgaatcagtt tgtaggctgt 2007481 tttttctcca atgcctttga ctccgggata gttatcactg gaatcaccca taagcgcttt 2007541 aatatcaatc aaagccttcg gcattacgcc tgtttcttca taaaaagtct cttttgtata 2007601 gactttataa tttccgattc ctttttgaag caaagcaacg cttactttat ccgttaacag 2007661 ctgaagtaaa tctctgtccc ctgttaccac cgtaatgtcc gcttcattcg caaataaatc 2007721 ggcaagagta ccgatacagt catccgcttc atagccggca aagccaatat tcatgattcc 2007781 aagctctgcg gctgcttcct ttgccaaatc aaactgcgga atcagctcca caggcggcgc 2007841 gctgcggttg gccttataat cttggaacaa gtcatttcgg tacgttttgc tccccatgtc 2007901 ccagcagcag acgacgtgtg tcggctggaa tgtttccaca gctgtaatca aatgctttaa 2007961 aaagccgttg acgccgttcg tcggcacccc gctgtcattt atcataaagt tgcgatgtac 2008021 ggccgtggca aaaaaggccc ggaataaaag agccatgccg tcaaccagca atagtttatt 2008081 attattcatc aaataactcc cttttctttc attccttcta ttttatcata aagcagccca 2008141 aaaataaaaa acagtatctc tttaattaga gatactgttt gaatatttat caatcgttgt 2008201 gtcttttgtt gctggcgatc agcttttcag cttcgcgtcc tgcgtaagag tcaaaatggg 2008261 tttgaaatcc gtttttcttt ttggcgttgt tattcgcctg tgcatttctg tttccgagct 2008321 ttgttctgcc caacatgaat ccccccttac gtcggatgca tatagtatat gcttccggca 2008381 ggaggttcac tcgcgacagg atcatccagc ttacatgcgg cttacgtatt ctctgaccat 2008441 ttcttttgat acaagccgtc ttgtcgggac gatgcctttt ttagcgagct gattcatttg 2008501 ctcggtaatt tcattaattg catctgtagt ataaggctca tcgtttctgc atttagcaac 2008561 agcttcttca atcgccaatt cacgcatatt ttcaagacgc ataaatgctt tgatatgctc 2008621 gtgctgtttt gatgaatgtg ctgaaattgc tttatgtacc tctgacatta atcgttcatc 2008681 tcgctttttt ctatttagtc tatcatgact tgaaatacaa gccaactgaa ttttacattt 2008741 ttattgtatt gtctgaattt ttccaggaga tgcacgcctg atacgccatt tcaatctctt 2008801 tcgcatgttc cccttccgca tatcctctta aatatgtctc tttttgatcc gttatttgcg 2008861 cgattgcttt ttcacccata tcttcctgta agcgtctgag gtgagcagtg taatgagata 2008921 tcaggctttc ttcttcattt tttatccatg cctctgtgat tttcgtaagt ttcatccgta 2008981 cagcttcgat aaaggtcgct tttcctttct gctcaaaaaa ctgcttcggt gatttgatct 2009041 cttttagttc ctgctcaaaa gcacgttctt ctatttccgg ttcaacttcc ttcaactgta 2009101 tgccgttcga atgctgatca cccgcataaa cggaaaaata accgtcctcg tttaatgttt 2009161 tttgaaaatg atccagccat tcttcattga tatgccgttc gatgaaaccg ctcatgcgaa 2009221 catcaagcgt tttgatttcc tgaatatatt caaatagata ttcatgtaag gctgttgtca 2009281 tcgctttact gacgttcttt ttccaatccc cgttttgcag cccgggatga aatgccgatt 2009341 ttaataaatc atttgcaaaa tatgataatc gctgtgcaat gtgatatagc tgctctcttg 2009401 tatctttttt tactttttca atgatggttt ttgagttccg ccgtttctcg atatcggccg 2009461 ctgtccgctc aaatgacagc ataaggcact gtttctgcgc ttccttctct tctcgggact 2009521 gatgctggga ttggtgaagc tgaaaaacag tttcgcatag tttgtctgcc tccgaactga 2009581 gctgcgctgc tgacgctttt tttacatcca cttcgataaa ccggtctaag tgttttctta 2009641 ctttcgagaa ctgattataa aatgactccg gttttcccac cagttcctcc ttacttgata 2009701 cggtaaagag ctgcggctca taaacccctt cttttacaag ctctgcgctg acataatcgg 2009761 tcactgtttc gagctctgtt ttatcttttg caaggtctgc agcattaata ataaaaaaca 2009821 ttttatccat gctgagcgat tctttcacaa gtccaagctt tcgcaaaaat gaacggtctc 2009881 cttttgaaaa agagtgctga taataagtca tataaaaaaa tgcatcagca tctttgatat 2009941 attggaatgc cagttctgta tgccgtttat tcatgctgct cgcgccgggt gtatcaacga 2010001 tcgtaatccc tttttcagtg agcgggcatg tatagtagac cgttacctct ttcacagcac 2010061 aggccgttgt ttcctctgct acatacggct ttaattcaga gagcggaatc gttaatttct 2010121 tctgttcctg tatatactgc tgatacttct cgtatgcaag caggaaattg ctgatcaatt 2010181 tcacgtgttc ttcctgcagc ctgttttttt tgactgcctt ttcccacttc tctgtgaagg 2010241 aacggcctgc cggctccttt ggtattccgg tgagctgcaa aatttcagcc gttaagtcat 2010301 cctctgtctt aaacactaca ttcgctgttt tgtttaagtt gccattgatt ggctttgtga 2010361 tcttgttaat tgtcgctgtg gttggcgttg gtgaggatgg cagcactctt tcgccgacaa 2010421 gcgcattggc aaatgatgat ttccccgagc taaagcctcc aaaaagagcg agtgtaaatt 2010481 tccgttcctc aagccttttc accctttcac gaaacgctga agtttgcttt aacaacatgc 2010541 tgcattcgcc taaaatgtca gacaaagtgt aaaagcgttt gatttggtct tgaagcggca 2010601 tttcttgttc cattttgatt tctgatttcg gcatcggctg cgccgtcagc tggcttcggc 2010661 cttgtttctg ctctggagcc gccactcttg ttttcttcga tttaaaccat tctgtgtcta 2010721 tatgcattgg gcatgcggac tcttcttccc aaatggccca caggcgatcg gttttctctc 2010781 gggcattatt ctctaaacgt gcctgttctt gaagaaagac aagtttttct gattcttgga 2010841 cgagccggtc gttaattgtt tgcacatctt tggaaacacg ctctttcacc atagcggaga 2010901 gcacctttat gatgtctgcg gcttctcttt tcgcctcttt ccggatgagc tctgccaagt 2010961 cttttgtata ttgcaataca tattcagagg aaaaggctgc accatgcttg accgcgtgtt 2011021 caatgatgct tatatcaagc ggtgtgcgat aggcctgaat cagcttttca ctttcagcgg 2011081 tatagacatc aaataccttg gcgagtttat gaagcgtgtc tatcatatgc caatccgctt 2011141 cggcctctgt tcgttttgcc acatcagaga aaaaagcatt ccgcctttta tctctttcct 2011201 gtgcagtttt cgctttagaa aagaaaaagc cggttttaaa ggaaggctct tgtgattcta 2011261 aaaatgcagc cgccaattca cgcatttcaa aaggcgtcag gttggcgttt tttaaaatac 2011321 gattgatttc ttcctgcatc ctcttctctg cctcagtcat ttgtttttcg gcctcatcca 2011381 attgatcacg cagcgattgg accagtccag tatggatatt aagctgttca gcgaaactcg 2011441 gagcgcctgt ttcgtctttc ttcagcattt ccgtatgttc ctttagcaga ttacggactt 2011501 tttgttcggt taaagcctgc atattgcttt ttgattgctg ttctattctg cttaactctt 2011561 ctctcagggc ccccatctga ttgaacgggt gatccggttc tgttactgat gtaaaataga 2011621 gcgcttccct tgaaatccct tcattgcaaa gcatctcctc tacctgcgct tgatagtctc 2011681 caaatttcgt ctccgtctca tcatggcggt caatttgatt gacgataaaa tacacattcg 2011741 gaatgctttc ttttattgat ctgagaaact ttacattttc ctcagcgtgc acgtgattat 2011801 agtgaacgac gtaaaacagc gcatccgctt ggtgaagaat agaagcagcc gatagaaaat 2011861 gcgcatcatc tgttgaatct atccctggag tatcaatata cgcaaccccg gaatcgatct 2011921 cagtatacct gtcaaaaatt tcgacgcttt caatctgttc cccgtcttta caatattgct 2011981 gcaccttgtc tttctggtaa gtcccttcca gctcagcaca cgctccgtct gttgtatgaa 2012041 gccgaactcg cttttccccg tttctgatca caacaaggtt agcgcttgtc ggaatcgggc 2012101 ttgtcggcaa aatattctcc attaacaggc agttcagcag tgacgatttc cccgctgaat 2012161 aatgcccggt aaacgcgata taaacctctt catcagccgc ttttttcatg accgcagcca 2012221 gtttagcagc cctttgttca tcttgattct caataaattg cttataaagt tccccggttt 2012281 tatgcaaaag ctcttttctg ttttgatctg tcataagtct gaaccccttt gtgccgtttc 2012341 aattgtgaac ctttttcgaa agatctgaat tcattccctt ttcattttac acaagaataa 2012401 accaaatttc tttaggagaa tagaaaaaag ccgccattac ggcagcttct ataaaagaaa 2012461 atctgcaact tttacaagtt ccagattcat caaacagatt tattagagat tccttttaat 2012521 acaaaaccaa ttaatacact atatgtacaa accgctccaa gcaaaaacag cattgtcatt 2012581 tgcttcacca tcctgattga gaatcttttt caaacccatt ttaacatggt tgagaatgat 2012641 tttcaatcgc tattttacgc tgtattcctg taatgctttg tcttctgcgc gaattctgac 2012701 gcttaacaac acggcattga aaatggaaaa cagacacatg gtgacgtatg cttgataaag 2012761 cagcggaatc agcaaaattt cgaggataac aacggcatag tttggatgtt tcatccattt 2012821 atatggacct ttttttacaa gctctacacc tggaacaaca aggattttcg tattccaata 2012881 tgctcctaag gaacaaagcg cccaataccg tacgatctgt acgcttaaaa tcactgcagc 2012941 gataccgagc caccagctgg acggctgttt attcatcagc agcacctcgg caattaagga 2013001 caggaaaaaa aggatatgca tcgtaatgat atacggatag tggctctcgc caaattcaat 2013061 tgctccttgc ttctttacct tttgttcgtt ttgcctggcc actgccattt ctgctgctct 2013121 ttgaacaatg agaatggcga tcaacaacca aaacatgagt caggccccct tttcccagct 2013181 gaataatagc aactctgatg agaaacccgg ccctaatgcg ccaatcagtc ctcgttcagc 2013241 ttccttttta tgtccgttct gcagatggtc tttgatcaca tacaagattg tggctgaaga 2013301 catatttccg tgcttttgca aaatgctttg cgcagatgaa agcttttctg acgacagccc 2013361 gagacttttg atgtatgcat cgatcacttt ttttccgcct ggatgcgcca aaaaaacact 2013421 gatatcatgg aatgacagct tatgtttgtc caaaaaaatc tgtacatttg ttttgagcca 2013481 tttttccacc aaggtcggaa tgtctcgtga gaaaatgact ttgaatcctt gatcggtaaa 2013541 gtcccagccc atgacatctt ctgattgttt catcaaaaca gattgggcgt ccattatctt 2013601 cggcgcaagc ttcagctttg acaccctgcg gtccgccttc tctccgcata ataaagctgc 2013661 ggcaatgccg tcaccaaaaa gcgaggtgcc gatcagattg ctttttgttt tatcttccgg 2013721 ctggaatgtc aggctgcaca gctcggcaga aatgacaagc acaaaagcct caggatacgc 2013781 tttgcagtat tcggctgcac gcgcaagtcc gctggctcct cctgcacagc caagccccca 2013841 aatcggaatc cgcttcgtat atggagaaaa cggaagttca ttcataagcc gcgcctcgat 2013901 actcggtgtg gaaagacctg tactggagac gaaaaaaaca gcttccactt tctcataagg 2013961 aatggcttct tgaaaaaatt ccggatgaga gaggcactca cgaacagccg ctctgctgtg 2014021 tttaagtgtt tcttctatgt atatttgatt tttttcttca aagctgtgcc cctctttata 2014081 ccattcaatc ggcttaacaa actgtctcga atggatttgc ccgtttttaa aggaggataa 2014141 cagcctgtca atatccttaa aagaatgctg aaacatatag cgggcgaact cggccgcttt 2014201 ctcttggttt acattatacg caggaagact tgttccaatg gataaaataa acgccatgcg 2014261 atcacctctt tgcatacatt gtgccgcaac aatctttttt atatgcaaaa aaaactccgc 2014321 cgcggcggag ttagactgct gttttttgtt cagcgaggtc agcttcttgt tctatttttt 2014381 tagctttaga aaaaacgtta tatacaatat ttaagacgac tgcagtaaag ctgcccgcca 2014441 caatgccatt cgttgtaagc agcgttaagg cactcggaag ctgtttgaaa atatccggca 2014501 caacggtcac accgagcccc aatcccactg agcaagcaac aatcagcaga ttttcctgtt 2014561 tcgcaaaatc aatgcggctg agcattttaa ttccgtaagc aatcaccatt ccaaacatcg 2014621 ccaccattgc accgcccaaa acagcggatg gaataatagt cgtgaaagca gcgatctttg 2014681 gaaacagccc aaatgccatt aggatcacac ctgtgaccac aatgacggca ttttttttga 2014741 tccctgtgag ctgaacaagc ccgacatttt gagagaatgc cgtgtaagga aaagcgttaa 2014801 aaataccgcc cagaagcaca gccagtcctt cagctcgata gcctttagac aaatctatct 2014861 ctgtcaaacg gcggtttgtc aggtcaccta aagcaaagta aacaccagtt gactccacaa 2014921 ggctgacaat tgcaacgatg gacatcgtaa tgataggcgc tgcgtgaaaa gacggcgctc 2014981 cgaagtaaaa tggctgaatc atttgaacaa ctgccgcgtc cgaaacatta tcaaattgaa 2015041 cttttcccat aaaatatgcg atgaaggtgc caatcaaaat accgatcaaa atcgagacgg 2015101 acttgataaa gccttttgta aaacggtata gaagcacaat gatactcaac acggtaaaag 2015161 caagtgcaag attggagaga tctccgaaat ctgcacttcc ttctccgccg gccatgttat 2015221 tcatggcaac cggcatcagt gtaataccga taatcgtaac aacagagcct gtcacgaccg 2015281 gcggaaaaaa cgatacgagc tttccaaaga aaaatgaaat aagaatgaca agaatgcctg 2015341 aagcgataat gctgccgtaa actgttgaaa ccccatattc agatccaatc gctatcatcg 2015401 gcgatacagc tgtaaaggta cagccaagca ctaccggaag cccgatccca aaaaatcggt 2015461 tgctccacac ttgcagaagt gtagccacac cgcacataaa aatatcaatc gatactaagt 2015521 aagtcagctg ctcgacagtc agtcccattg cttttccgac aatcagagga acgacaatgg 2015581 cgccggcata catggcaaga acatgctgaa tccctaaaga cagcgttttg ccgaatccat 2015641 ttctcatgaa tgaacctcct gtacgaagga cacttttcct tcttctaaag actgaattct 2015701 tgccaaagat tccactcggt agcccagttt tacaagttca tctcttcccg gctgaaatga 2015761 cttttcaata acaatgccga ttcccgcaat agaagctccc gcttgcttca caatcgacac 2015821 aagcccgtgc gctgcctgtc catttgccaa aaaatcatcg ataatcagca catgatcctg 2015881 atccgacagg tgggtcccag acactgcgat ttggctttct gtttgcttcg taaaggaata 2015941 aacagacgct gtcagcaagt tgtcggtgag tgttaacgat ttatgctttc tcgcgaagac 2016001 aactggcaca cccagcttca agcccgtcat tacagcggga gcgatacctg atgattcgat 2016061 tgtcacaatt ttggtaatac cgtcttttgc aaacctagac gcaaattcat caccaattct 2016121 ctgcataagc agcggatcaa tttggtgatt caaaaaagaa tccactttca atacctgatc 2016181 agataatacg acgccttctt cctctatttt ccgtttcagt gcttccatcc tgtctacctc 2016241 cgttatgaga ataaaaaaag cattgcccgc tcaaataaag agcaagcaat gctgatatca 2016301 caaaaaaccg tacacgtgcg gttccattgc tcacccatag tcggacattt acggtgcccg 2016361 gtagaaactt gcgtgccata tccacgcgat tatatgagtg ttcctattat attgtaataa 2016421 attatatcaa gattctaatc tcttgcatag gctgaaaata aaaattcccg aactttaatt 2016481 ttgttttttt agatatcatt cgtatttcaa ggggattcga tataaaagag tctgacgacc 2016541 gcgccgccag gcttttgatt ataacagata gagatttgaa tatttgtttg ataaataatc 2016601 aattaaatag cgaacattca gctcttctcc tgttgcatct ttaataatgt ctaacggctt 2016661 tttccgtttt ccgtgaatgt gcaccttttc cgtcagccat tgctttatcg gatggaactc 2016721 tcctctttcc aagagagcgt caaattcagg gagatcctca agcatttttt gtttcagctg 2016781 agccgcatac atgtagccga gcgcatagga tgggaagtag ccgaaatctc cacctgccca 2016841 atggacgtcc tgtaaaatcc cctctgcgtc ggtctgcggt gtaatcccta aataatcctg 2016901 gtatttttga ttccaaagcg acggcagatc ttccacagac acttcattgc tgaaaatcgc 2016961 tttttcaatt tcataacgga tgatgatatg aagaggatac gtcaattcat ccgcttcgac 2017021 cctgataaat gaaggttttg attcattgat tgcccggaca aaatcatcca gggagatgtc 2017081 cttgaactgt acaggtgatg cctcttgaat cttcttatag tacggagtcc aaaaatgctt 2017141 gttgcggccg ataaaattct cgtaaaataa tgattgcgat tcatgaattc ccatcgatgc 2017201 gccgtctgac aagttcgtgc cactgagtgc ttcatcaata ttttgctcgt aaatcgcgtg 2017261 cccgcactca tgaatggtcc caaagatcgc cgtccggaaa tctttttcat catatctcgt 2017321 cgtgacccga acgtctcccc gattcagcgt agttgcaaac ggatgaacgg tttcatcaag 2017381 tcttccgcca tcaaaatcgt agccaagctc ctgtaaaaaa tacagactga gctctttttg 2017441 cttttctttc gggaacgctt ttgtaataaa gcttgtatct ggtttatttc cggaagctgt 2017501 cacctgttta acaagaggga taatcgcttc cttcagctca gcaaacaact gatcaagcac 2017561 ctttaccgtg acgccgggct caaacaaatc aagcaatgca tcataaggat gctcttgata 2017621 tccccaatac gtaataaaac gtttattgaa ttcaatcagc tgttctaaat aaggagaaaa 2017681 caagctgaaa tcagattttc ctttcgcttc ctcccacgct gtttctgcct ttgaacacag 2017741 aatcacgtat tctttgtatt cagcctcagg gattttctta ttctcttcat actctttttt 2017801 cgccagttcc actgcttttt tcgtatcttc cgacaagtca tcaaatcgtt catacaggac 2017861 atcgataagc tccttcattc gatctgatgt ttggatattg aatatatctg ttgaaagctg 2017921 gccgatactt tcggcacgat cctctgagcc atttttcggc gcgcctgttc tggagtccca 2017981 gtgcattaac gcaactgctt cgctgtaatg tgagattctt tttaaaagat caaaaaattc 2018041 tttttcatat gtatgtatct ccatatccat tccctcccta ttctagccgt tccattacag 2018101 gctaatggaa gggggtatga aagtcaaatt gtttgtataa aaggctgccg gtatgttttg 2018161 tggcagcctt tttattcagt tgatcgtcat ttgatttttt ggcggaggtg ttctccgctt 2018221 tttctgcttg atttttttat ctacccacac tgttgccagc ggggttaaga gcgaggtgac 2018281 aataacgctt gtcgcgataa ttgcagttgc cgactcagca actggcgcaa atgaggcatt 2018341 cgcttccgct aatgcatatg gcacggctac agccgcccct gccgtagaag aagcggccac 2018401 tcccgcgaca ccatctcccc gcgcaataaa acgatcaagc aaaaacaaag aactgcccga 2018461 taaaatgacg acagaaactc cgataaaaat gccgagcagc cctgattgga tcagcattcc 2018521 aaaattcaag gtattgccga gcgaaaaggc gaaaaatgga atgatcgccg gcacaacctt 2018581 gctgaataag tctctgagat catgatccag atttccaagt atacatccaa gtaaaaacgg 2018641 gatgactgtc gctgccagcg tttcccatgg gaatgcggca agtcccgtca caccaaacgt 2018701 caccatggtc ataaaaggac cagattctgt actgataaag gcgaaagcgc ccgcatcctc 2018761 ttttcttccc atgtgattca tgagcgccaa atacagtccg ccgttcgttt cattcattac 2018821 cgcgacaatt gctaaaacag aaaggcctgc aaaaaagccg gattgtatgc catcgtcagg 2018881 tataaattgc gctgcgatca cgccgagcag cgccgcaaat ccgatcttcc ccaataataa 2018941 cgtgattcct tttcttgcga tatagcctga agaacgaaaa tcaatcgttg ctcctacgca 2019001 aaagataaaa acacccagta tcggcagcgt tccggtaatc aaagcacccg taaaccctcc 2019061 aaagaactcc gctgttccag gcgcaaacgt gttgagcgcc gctccaagaa atagcggaat 2019121 aatcatcatt ccgccaggta cccgttcaat tgtcgccttg attttcatat tgtggattct 2019181 cccatcctcc ggttatgaaa aaacaattcc acttacactt ggaaaacagc ctgcaaatcc 2019241 tcttttgaac agctgcccaa ctggctgccg actccgacgg cgccagctcc ggctctaagc 2019301 caatcaggca cttcagacgg atgtatcccg cctgtcggaa taaaggtcac ctgcgggaaa 2019361 ggacccgcta aatttttcat aaacggaatg ccaaacacac cgcttgggaa cagctttaat 2019421 gtcgtaaaac cgaatgtcag cgcttccata atttcgctcg gagtcaagac gccggggata 2019481 taatgtgtct ttacaaaaga tagatgttca gcaagatcag ctgaaaaacc cggactgaca 2019541 ataaactgcg cgccagcctt agcagcttcc ccagcttgct gcgcgctgat gaccgtaccc 2019601 gcgccaatta aaatatcttc cctattacgg aaggattcga taatatctga tgccccgggg 2019661 gtcgtatacg tcacttcaac tgcacgaatc cctttatcta ataaactctc aatctgctga 2019721 caggcctcct gcttatcctt tgaacgaatg actgcaatca gctttgcttc tttcagacgg 2019781 ttttcaacga ctttggactc catattaata atcccctttc ttttggtgaa ccgttctttg 2019841 agcagataaa aaagaagcta atttctccct ggtcggcaaa ccgtccatat cccccggtgc 2019901 ctgcacttgc aaagcgccaa tcgcatttcc cctttgcacc gcatccttgt acgacaaacc 2019961 gtctaggata ccgctgatta caccgactgc aaatccgtct ccggcgccga ccgtatcaac 2020021 cacccggtcg acccggcagc cttctagaaa tccttcactt gtccccgttt taaagtaagc 2020081 gccttctttt ccaagtttaa tagcaacaaa gctggcacct tttttcaaat aatagtcggc 2020141 aatgccttca ggtgtttttt ctccggtcaa tagctctccc tctgcgatac ccgggaaaaa 2020201 ccagtctgca agcccagcca gatcattgat tgtgtgtacc attgttgctt gatcaggcca 2020261 aagcgaaggt cttacattag ggtcgaatga aatggtcttc cctgcgtttc tcatgtcgtt 2020321 catgacatga tacgtgaagt ctttcatctc ggctgataaa gcaggcggaa tacctgtcac 2020381 atgcaaatgg cctgcgcatt gaaaataatc tctcggatat tcagctgtag ttaatgtgct 2020441 tgcagctgag tttttcctat agtaggtaac ttgcgggtcg ccttctttca cttttgactt 2020501 cagcagcagc ccggtgggat tttcgtcctg cgagcggatc acgcgggaca catccactcc 2020561 ctctttttta agctcttgta aaataaacgt tccgagctga tcattgccga ccttgctcat 2020621 ccatcccatt cgaaatccga gtctggcaag gccgcaggcg acattgcttt ctgctccggc 2020681 aagcccttta gaaaaagtgg atacttcatg aaggcctcca tactcatttg cataaaacat 2020741 ggccattgat tccccgaatg tcaccgcatc aagcttcatc tcttcccaac ctcctcttag 2020801 ttgagggcac ctaggattaa agtgactttc tcatgatgac ttttgcctct aattcaatgg 2020861 tttgaggcgc tcctttgtca ccttcaatcc tttttaatac acgttccatc gccgtcctgc 2020921 ccatatcatg tgacggctgg gcgatcgttg taatgcctgg accgatcagt ttgtaccact 2020981 ccgtatcatc gaatcctgca atccctatat cttgagggat gcgcaggcca agctcttcca 2021041 tacagctgat gattttcagc ataatcaagc cattcaaagc cagaatcgct tttttttgct 2021101 ccggcatttc cttgtgaaaa gaacgaagct ccgccttaag ctgctccttg tcctttacgt 2021161 caatttcatg caatctgaca agcccgttca cattttgaac cgaagccatt tcctgataca 2021221 cagctgctct ttctgcacga gggctgatag aggaaatcgg ttcggtaaac agcgcgacat 2021281 cagtataccc tttgctgtac accttctgaa gaatctcttt tgtgatccat ctgttgtcag 2021341 tcgttacggt atccagtttc agatccggca gtttccggtc aattaagatt gttggaattt 2021401 gctgttcagc aaaagcgcgg agtacatcct tgttttcccc tgttgcgttt aaaatcaagc 2021461 cctcaaccga atgggcttct agctttaaga gcatttcccg ctctttttca ggactgttat 2021521 ctgtgttgca caccataatg ctgtatccat attgatcaca aacctcttcg actcccctga 2021581 aagcagcgac cgaaaaagga tttgtaatgt cagccacaac aaatccgatt aacttgcttt 2021641 tttttatttt caaaccttgt gccattttac tcggccgata attcaattct gcgattgcct 2021701 ttttaatgtt tttcactttt tcaggagaaa tcgcgtcaat ttttccgtta atatagcggg 2021761 aaactgtcga tttcgaaact cctgcacatt cagctacgtc tttgatggtt gtatggcctg 2021821 ttgttttctt tttcattcaa gtgctcctgt atctcatata tttgaaaccg atttcaaaac 2021881 cgttacaaca aaagaatacc ataattttaa aatttgggaa gagttttttt aataatatgt 2021941 caattcatta ttttttcgtt gactcttttc actatttatc ctaaaatttt ctttgaaacc 2022001 gttaccaaaa tattttcatt caagtgatgc tgaaatccta accaaggggg aaatataatg 2022061 gaaaatcgtt attctgtaca tcctgaacaa gtaaaacgct ttacaacaga ggagcttcgc 2022121 agtcatttct taatggattc tttatttaca gaaaacaaac ttacgatgta ttactcacat 2022181 gaagaccggg ttgtcatcgg cggagcggct ccagggcaaa gtgaactgaa gcttgatgca 2022241 ggtgattttc taaaaacaga cttctttttg gaacggcgtg aaatcgggat tattaatgtc 2022301 ggccagcctg gtgccgttag agtcggcgat gatgaatatg tgcttcaaac aaaggatttt 2022361 ctctatattg gaatgggcaa tcaggatgta tcgttttcaa gcctgaacgg ggaaaaagcg 2022421 aagttttact tcgtctccgc ttgcgcccac aaaagctatc cgacacaaaa agccgcccta 2022481 tctgaactga caccggaccg ccttggtgat gatgcagcgt ctaatgtcag aagtctgtac 2022541 aaagtcattc atcaggatgg cattaaaagc tgtcagctga tgatgggaat aacgatgtta 2022601 gatcaaaaca acaactggaa taccatgcca gcacacgttc atgaccgtcg gatggaggct 2022661 tatctttatc tggatcttga aaaggactca aaggtatttc atttcatggg ccagccggac 2022721 gaaacacgcc atcttgttgt tggaaatgag caggctgtcc tttctcccgc ttggtctatt 2022781 cattctggcg caggaacatc aaactatagc tttgtgtggg cgatggctgg agaaaattac 2022841 acatttacgg acatggatct cattccaatg gatgggctga aataagatgg gttatctaca 2022901 tgacgccttt tcattaaaag gaaaaacagc gctggtgaca ggcccgggaa cagggatcgg 2022961 tcaaggaata gccaaagccc tagccggggc tggcgctgat attatcggca catcacatac 2023021 aagcagtctg tctgaaacac agcagcttgt ggaacaggaa ggccggatat ttacatcttt 2023081 tacattggac atgagcaagc cggaagcgat aaaggattct gcagctgagc tgtttgaaaa 2023141 caggcagatc gacatccttg tcaataatgc cggcattatt catcgggaaa aagcggaaga 2023201 ttttccagaa gagaactggc agcacgtact gaatgtcaat ctaaacagcc tgtttattct 2023261 gacacagctt gctggcaggc acatgctgaa aagaggtcat ggaaagatta ttaatattgc 2023321 ctctctcctg tcttttcaag gcggcatcct cgttccggct tacaccgcga gcaaacacgc 2023381 tgttgccggt ttgacaaaat catttgcaaa tgagtgggca gcgtcaggta ttcaggtcaa 2023441 cgcaatcgcc ccaggctata tttctactgc gaatacaaag cctattcggg atgacgaaaa 2023501 gcgaaatgag gacattttaa agagaattcc tgccggccgc tggggccaag cggatgatat 2023561 cggggggact gcagtctttt tggcatcacg tgcttcagat tatgtaaatg gacatatttt 2023621 agcagttgat ggcggctggc tatcccgctg acaaataaaa aagctgacga acgatcgtca 2023681 gcttttttcc attacatcat gtgcggttca acaggcaaga cctttttgac ctcatcaatg 2023741 atgcgttcat tttctccgcc agcgtaaatg tgaatcgagc cgctgtcttg attcgagcga 2023801 atcaggcgcc cgatgccctg ccgtacacgt aacaacatat atggcagatc aacttcttcg 2023861 aacggatctt ttttcgctcc gttgcgcttc gctgtaaata caggatcgtg tggcgggaac 2023921 ggtaatgacc aaatggtaac attcttcaat gcgtcaccgg gaatgtcgag tccttcccat 2023981 aagtgaactg aacaaagtac tgtttcttct tcctcttgga atttctctac taagctgctg 2024041 atttcctcat caccttcgaa gaaaattgga tacggcagct cccatgccgc cgacagctct 2024101 ttaaactcgt ttaattcttc aaaagaaggg aaaagcacca gcgttcttcc tttgtatcgt 2024161 ttgattgttt caatcgtttc agccgttttt tgttcagcgt ccatatctgt ttttgcgtat 2024221 agattaatac tcatttgctc gtcataatca taaggggaat caacagttaa tgacaaataa 2024281 tcatgaatcc caagactgtc ggcaatataa tcaaacgaac cgccttctga cagcgtagca 2024341 gaagaaaaga tataaggaat tttcttagaa aacacttttt cgccaagtac ttctgctacc 2024401 gttctcggca tcacgacaaa ggttgattct gcttcctttt tctccagcca gctgatcgca 2024461 tccttttgat atagagataa tgaatacgcc atttgttcaa catattcttc cactactgac 2024521 agttcgtatt gatcaatcgt atacatttca gactcaaata caagtgcctc accgatttta 2024581 tcaagtaaac ggcaaagctc gtccgccgcc tttttgacac gatggtcatt ttttatttct 2024641 aaacggtgtg aaccggctac ttcctttgat tcttcagaaa gaacatagaa aaattcgtcg 2024701 tttgcgagaa gcgcatcttc aatcaattct gcaaactctt ctctgatgtc attttgcagc 2024761 aatcgttcta aaaacaattc aagagtagac tgcttcactc tataggttag cgctttttgc 2024821 gcagcaaact ctaacaagtg cccctcatca aatacaactg cactatgatc aggcaagagc 2024881 ggcagctggc cctctcgttt gcgtgattct tccgtccaca catgctccat ataaaaatca 2024941 tgggaacaaa tgattaagtc cgttgacttg cggtagtaat ctctggaaag tgtcagaccg 2025001 catctgtgtc tcatatcaca agtcagacag tcctgaaacg agtcgtagct tacgtcagac 2025061 cactcttcat tcgatagatt tgcgtactgc ttacggtcgc catacggata aaagcgctgc 2025121 atcgcctggg actcgtggac aaatgacggt aacgactcat aaagatccag ccatttatca 2025181 tcatcagaac gctgcattgt tttttcaagc ttcttcaagc ataaatattg ctcatgtgat 2025241 tttgacagcc ttgtatcaat tttcagatca agatgctcag ccagcttaga aatatcgccc 2025301 tcttttttca ccagctgttc aattaatgtt tcatccgcac aagcgatgat ggcaggtttg 2025361 ccgacatacc ttgcatagct gattgcaaaa agaagatata ccagcgtttt ccccgttccc 2025421 actccagctt cggcgaacat gacttttttc tctttaaacg cccgctccag ctgaaaagcc 2025481 ataaatactt gctcgtcccg aagatcaaac cctttttcgg gaaggatatc gtaaaacacg 2025541 tcaccaatcc aattgttcaa ttcttcataa aaattctttg ttttcgttaa agaaaaaggc 2025601 aaacgtgatg ttgtcaccta gttccaaccc ccaactattc gacattcaga ccaccaataa 2025661 tatcattttc cgctgatgaa tacaataaaa aacttggcaa tgccaagttt tttgcagttt 2025721 acttacgatt gatcacatgc gacgataaaa aaggatggtc tgttgaataa atatgttcta 2025781 ccgctttttc taaatcagtt tgcgcatgcg aaatcacaga cggagacgaa tcagtcccga 2025841 gctccttcag ctcgtttgct gttgcgtcaa gcgccctttg aataagatta aaatgttcgc 2025901 tgttcagcat gagatcacct ctgatggaaa taatcatcat tgtatgcgaa cttttcattt 2025961 tatatacatg ctttaccgca tgttatcacc gaaacatgca caaactacac ttgatattcc 2026021 gtctccggat tatccgtctt atcaacaata ttctatcagg gagtgatgtt gacatgagtt 2026081 atagaaaccg attagatcag cattctgaac tgtttcatca caattggacg cggcctaaac 2026141 gttcaaagtc tcaagtaaac ggtcacactg aaatgtccca aaccaacatt atattgagaa 2026201 gcaacgcgaa agctcaccgt tggtaacgat agaatagggc tgaaagatga aagaagacgc 2026261 atgcagagcg tcttcttttt atgcgttttc tgttttcttg cgctgcggtc ttacttttga 2026321 ccagtattga taataatccg ttttaataaa cccgttaaag agttttcgtt tcttcgttgc 2026381 ttttctgcca tatgcttcct caaagttttc atttgatgtc agcatataca cagaccaagt 2026441 atcaagcggc tcgaacgcct gccccatttc tttgtacatc tgctcaacgg cttttttctc 2026501 gccgagacgc tctccatatg gcgggttgcc gacaattacg ccaaattcca gatttgtggt 2026561 aaagtctttg acctgcatct gtttgaactg gattagatct cccaatcctg cttcctctgc 2026621 attttctttt gcgatttgaa ccatgcggtg gtctatgtcg ctagcgaaaa ttgtaagcgg 2026681 ctgatcataa tttgcctttt cttcgacttc aagccgcgct ttgttccaca gatctttacc 2026741 gatccattcc caatcctctg atacaaaatc gcggttgaat cccggggcga tgttttggcc 2026801 gattagcgcc gcttctatcg cgattgttcc ggagccgcag aaaggatcaa caaacgggcg 2026861 gtcaggcgtc caattggtta attgcaccaa agcggcagca agtgtttctt taatcggcgc 2026921 accgccctga tcgacacggt atcctcgttt gtgaaggccc gtccctgatg agtccagtgt 2026981 aatcaaagcc tgatctttca ataaagatat ttccacttta tactcagcac ctgtttcttc 2027041 aatccaatca ttggctttgc cggactgcag cttgagcttt tcgacaattg cttttttgac 2027101 gatccgctga cagtcaggaa cgcttgcaag tgttgatttt accgattttc cgatgacagg 2027161 gaatttcccg ttttcaggta taaatgagcg ccagttaatc gctttcgttt tttcaaacag 2027221 ttcatcaaat gttttcgctt taaaagaagc aacctgaacc tttatgcggt cggctgttct 2027281 aagccaaagg ttcgcacggc agatggcaag tgcatcacct tcaaaaataa ctttcccgtt 2027341 atcaaccttg cattcgtatc ctaaatctcg tacttccttt gcgacaacag cttcaatgcc 2027401 catcggcgcc gttgcaatta gtgtatactt cttcatcgta tcaccctgtc ttttaaaact 2027461 tttctctttt caagataaaa gctctcctta tacgggagag cttgttttca tcattttaaa 2027521 tgtaagtggt ctaacgttct gtaagccatg ttttgttcca tcgtactgca aacggctcat 2027581 cacctcgtac tcaggcggca atcatctatc tacagaaagc attctgtcct tctctccgtt 2027641 gaattccgtt aagaaggttc ccctaccaaa atttgggttt ctcgctcgag gggtttaccg 2027701 cgttccactc tcaccatttc tagtgagact tcgtcactgt ggcactttca aggatactca 2027761 gccatatccg aagacgtagg cttttttcct gccgtcagcc tctaaagact gccctagctt 2027821 atgacttcgc taggcacgaa cactacgggc atctcagcac cgtgcgagca tggactttcc 2027881 tctacagatt caagatctgc agcgattacc cgaacgttaa gaacatgaat tattatataa 2027941 caactgatta caatttacaa gcgccatttt tttcaagcgt gatcaatcat aaagcttgct 2028001 gccaaaaacg tgtttttcta agttagacag ccgttttaaa atatcaaagt ttgttgtgtt 2028061 agattgcaca ggctgttttt tgctggcttc ttcaagctgt tttttcagct gcagattttc 2028121 ctgctgcagt tcttcaattt cttgatggaa ggtttcataa tccttaataa tcatatctaa 2028181 aaatttgtca acgtcttctt gcttgtagcc tctaacgcct gttttaaatt ctttttccaa 2028241 aatttctttc gcagaaagct ttactttatc agcaagcatc tttttcacct cgtatcgtga 2028301 atcatcacat atattttttc agaaatctgt acggttgtca aatttctctc tcattgttag 2028361 tagctgtctt cctccactgt cactctcaag tcatccattg taataaagta gatgggatag 2028421 ccatcctgtt cgcgcctttt ttccgctgtc ccaagcatat acttagggga gccttccttt 2028481 tccgggtcat ataaaagcag aagcccgtcg gacttatcaa tgaagaactg atttttttgt 2028541 ttgaattgaa gcgggctttc ataaggacgg tgagtcaggc ttgcttcata gtctgcctga 2028601 gccagaactg cttcatactg ttctttattc ggttctttcc agttcttttc ctgctcgtaa 2028661 aatggtgtga tgacagctac ctttaagtca gggtattcct cctgcaaatc atatgcagct 2028721 tctgccgccc acagctcaac tccaagctgg cccgaaatta aaatccattc taatccttca 2028781 tccaaaaaag caatcagccg gtttttaatg gcttttttta tgtaatacag cgccttgtca 2028841 tcctgcttaa atatccccag ttcaaacggt ttatagcccg ttattgccaa tactttcatc 2028901 atttcacctg ctttaaaaaa tggggctccc gtgggcccca tttgttgtgc tgcattgttt 2028961 acaccatcaa gctgcacgtt ttccatacta gtagtcgcag caaggttttc ctgcttgaaa 2029021 atgctgatgc gtagccgggt caacatttga gaaagtgtgt ggaaagtagt gaacgtgctg 2029081 aaaatgctgg tggtttacgt ttgttgtatg ctgtgggtga atgtgcggca cgatagtctt 2029141 cgaaaacgta tggtgttcac agcaatgagt aggatggaca attggcgcca tcatatgcgg 2029201 tctgcagtga tgcatgataa aatccccttt ccataaactt tattacaata ctaagttatg 2029261 aaaaataagg ggtacatgtt ctgatgcaaa gacctatttt aaaagtgtgc aattaagctg 2029321 tctttaaagt ttgaaaacac aaaagcaatc aaaaatacca caacaaagaa caagtaaaaa 2029381 acacccttat acataccaac tctcccttta aaaataacta acgtcatttt acaggattcg 2029441 ccgctattct acaacaaaat caatgtgaat tcagcaaaaa aaattcatgg cgaaacaagt 2029501 cgtcttttgc gctttcccgg ggaatattta agaggaatat ttcctcttta gccgggcaat 2029561 tctcacatgc agtttttcag tttctttctc tgataagcat gccgcatcgc taagcgattg 2029621 ctctgctact tgcaatgctt ttccgaattc ttttttctta tgctcaaaat atttcgcgag 2029681 ctctattaca gcagcgtatc tgcacttctg gttttgcgag cgggacagct tttcccaaag 2029741 cggcactgct tcttccaagc ggttttgttt tttgtacagg agcgataaat ccagccgtgc 2029801 actgtcctgg tcctcaaacg atttttctat aagcctttcc aactgcttga tcgcttggtc 2029861 cgtttcttta tgagccataa accatttcgc catagcatag gcttcactgt gttcttttgg 2029921 cgcatgtgat tctgaaagga tttttttaga catatggatg tacaatgaaa tgagtgataa 2029981 cacatccatt tcattatgat gcaggacacc ttttaaaaga tccggctctt gcgccttgat 2030041 aaaatgaaag taaagcattg gcgccaagta gcccggtgtg tcttctagcc tgcggatgcc 2030101 gagctcctct ttttcaaccg tgccaagaga tacacggtcc attttgtgtt tccacaggcg 2030161 tctagctcca tgcaaaagat caaagtggcc aaactccgga agcttcggaa gtctgtcacg 2030221 gatcaaggtg tgccttgttt tcacctgcgg ccaatcaaag gctttgccgt tgtaggtcac 2030281 aagtgatgta atgtcaacct cgcttaaaaa gctttggtac aaggcgactt cgttccccgg 2030341 tttgggcaaa agatgctgtt tgactgtcac tcggtcttca tatactctcg catgcccaag 2030401 caaaaaaatg gtattcccag ctccaccccc aagaccggtt gtttctgtat caaagaaaaa 2030461 gaggttgttt ttgttatacc cttttgctga caatgtatgc gacaggccgc tttgattcca 2030521 cagtgtgatc acttcctcaa gctcagaaaa gctgtataac ccatggcggt gagaaagcgg 2030581 atattctact tctctgatga ggcaatattc atcttcgaag atgaaaggct tcatgccaaa 2030641 agcctcccac tcttctaaaa acgggatgtc atcaaagtgg ttttcttgtt tgcctgcttc 2030701 tattttttgt tctccttcgt cgagcgccat gtgctttttc atccgttgga gtttcccttt 2030761 taatgacata tccggcctcc ctccttacga catttgatcc aacagctgca aaattctttc 2030821 ctttgctttt atcccttcta tttccgtacc tatacaagac ggacagccgt catgacaagg 2030881 acaatgtgta atcagttgtt tcgccgcttc attaatgtct gaaaaacgtt taaagacttc 2030941 ctccgccaaa ccgataccgc ccggataatg atcatataaa aatatggttg gcaatccggt 2031001 atgggctgct ttaatttgag aaacaacatg aacatcattt cgatcacaca tgatatacac 2031061 agggacaata tgctgcagca cattcgagat gccaagaagc agctgttcca gtgtcttttc 2031121 cccgatgtct tcatccgctg ttttgatttc gagccaagct gcacttgtat gcagttcttc 2031181 ttccggcaaa tgaataggtc cagacccaat attttcaaaa gtggtcattt ttattttttt 2031241 aaaaatggtc ggcagggcat tgacagtgac gtctccgtag tgcaatgacg tacggctttt 2031301 ttctttcgtt ttatcgattt ctaatacctt cagctgaact gccaggtttg catccgtata 2031361 atattcgaca tcgacttttc tgacatacgc ctttttatgg tcccaatcga gcttctcaac 2031421 ttgatactga acgccttcat gcaaataaat cgcttcatca tgcaaaagcg tcatcgcact 2031481 aaaacggtcc atttcaccga taatccttac atttgcaata tccgactgat caactataac 2031541 gacattttcc tgggaggcgg aacgcaaact gatgtttgac gcagggaacg actcacttgc 2031601 ccaatggtac cgttcgccgt tgcggtgaag aacagcctct tcctgaagat actcaagaat 2031661 atcactgact tccatggctc caaattcttc atcagctcta aaaggaagct cataagccgc 2031721 acactttaag tggtctacta aaataatcaa attctccgga ttgattcttg cagattccgg 2031781 cgaacgatta aagaaatatt caggatgccg cacaatatat tggtcaatcg gtgttgaatt 2031841 ggctaccatg ataatcaaag attcaccgtg tcttctgccg gctcgtcccg cctgctgcca 2031901 agcacttgca acacttccgg gataccccgt cattacacac acttgcagct ggccgatatc 2031961 aacaccaagc tctaaggcat tcgtactgac cactcctaaa atgtcgcctt ctctcagtcc 2032021 tctttcgatt tctcttcgct ctttcggcag atagcctccc cgatagcctc tgattgattt 2032081 tgttccaatc tcttttttca caagctcctg aatatggctt aaaataattt ccacccgaac 2032141 tctgcttctg gcaaaaacaa tggtctgcac tttgttttta aggaactctt tcgccagttc 2032201 attcacttct gcggttgcgc tccttctaat attcagcggt ttgttcacaa ttggcggatt 2032261 gtaaaacaca aaatgcttgc gtccgctcgg tgcgccgttg tcatcgacca gccgcatcgg 2032321 tttgcctgtc agctgctctc ccaattcctt tgggttggca atcgttgcgg aagtacaaat 2032381 aaaaactgga tcacttccat aaaaccggca gatccgcttc agccgccgga tcacatttgc 2032441 cacatggctg ccgaacacac ctcgatacgt atgaagctca tcgatgacga tatacttaag 2032501 gttttcaaac aaactgaccc atttcgtatg atgcggtaga atggcagaat gcagcatatc 2032561 ggggtttgta atgacaatat gacctgcttt tctcaccttt tgtctgattg ccggagacgt 2032621 atccccgtca tatgtaaagc ttttaatatc aatgcccatt tcatcaataa tttcatttag 2032681 ctcgctcttt tggtcttgtg ccagcgcttt agtcggaaat aaatataacg cccggtttgt 2032741 ttcatcttgg gcgatggact gcaggactgg gaggttgtag cataacgttt ttcctgatgc 2032801 tgttggcgtt acggtaacga tgctctctcc tttttgcaca tattgaaaag cggaatattg 2032861 gtgagtatat agttcatcaa tgcccctttt cgaaagggcc gctttgattc tctcgtctat 2032921 actttcgggc ataggccttg tttttgcttc ccgaggctca atttcatgcc aattcacaac 2032981 gttttcattt ccttttaaat cagaaatgag ttcagtcagt gatttctttt tcattcttta 2033041 cacctctttg tcaagtacag tttaccgaat atttgtttgc atggctaggt gcaaatttta 2033101 tacagttgaa taaaaaaagc aaggcatacg ccctgcttat ttcgctttta ttgtaaagag 2033161 ctttgattcg cctttacgag cagccttttc gcctgccgat accattgatc ctacagcctc 2033221 accattcatt ataacgattg ggatgactgt gctgctcgct ttttctttta ttaattccaa 2033281 atcacatgta atcagcgggt caccgacctt cactttatcc ccttctttaa tgtgggcagt 2033341 aaatccttct ccgttcatat tgactgtctc cagcccgaca tgaattaaca gctcaattcc 2033401 cgagcgagtc cgaatgccaa cggcgtgttt ggtgtggaaa atctgaatga cttcaccttc 2033461 agcgggagaa acgatttcac cgctagaagg ttccaccgct attccttctc ccatcatttt 2033521 ctgtgaaaaa acagggtccg gtacatctga caggtccatt actgtaccgt ctgccggaga 2033581 ataaataacc tcttctgtca ccttttcctg aattttgccc attccgaata attttttcag 2033641 caatgtattt tctcccttct cattcacttc aaccgttatc ccttcattca ccactattta 2033701 accacacttt caattttgct tcaatttata acaacatctg gcatagacgc ataatctggt 2033761 taaaaaaggc ggtggcgata ttggaattcc atgatgacaa aaagaacgaa ctgcaaaaga 2033821 aagaagaaat cataacggag gcaatcgaca ctctttttca atcctcagcg ttcggcaacc 2033881 ttataaacgg atttcagaac ctaatcaact cgagtttaaa ggatgtgcag acgaccatac 2033941 atgtcagaga aagagatact gggctgtata tcgatattac cattccggcg acgtttcgag 2034001 atggcgagat cgtcgttgat gttaaatcga ggtatctcca tgtaacactc caagaaaaac 2034061 agaaacacca aaatgaggct acctttacaa gcatgacaag aacggttcag ctgccttatg 2034121 aagttcgcca agaagatatg gaaacgtctt ggaacgagca gacaatgaca cttttctttc 2034181 caaaaaataa gcatgaatga acgattcatt catgcttcta tcatttaaaa aagctggtaa 2034241 atccctttat taaagatccg acctgattca ttgcactcat tacttgacct gtcgtatcca 2034301 tcattttatt aaaatcaaat tgcccattgg cttttttgaa ctgcgacata atgctttgaa 2034361 attgtgaagg ctgctgttga ttaggccttg ggataggata agggttagaa aatacaggcg 2034421 gctgcatagg cataggctgg atcggagcat aaggctgata ataatcctgc tgtccataat 2034481 gctgctgagg cagttgttgc tctaaataac cgggtgcagc ctgctgataa tatccttgca 2034541 tatgctgagg ataataatag cccatttgcc gaggatagct tcgagagctc ccgttcattg 2034601 cgattccccc ctaaacacaa catatttctc ttctatatat gtatgaatga cttctattgt 2034661 ttgtgtcaca agtgatgatt agcatttgtc aaattgtgtc gaaagtttaa attttttaaa 2034721 aacagaaaaa agtcgaatca ttatggtacc atattttcaa tacagatgag aggggatgca 2034781 ccataatgaa cgtatcatac ttaagcaaac gttttgcaga aatgaagaaa tatgaaacag 2034841 actgtatgaa taaactgatg gactttgcca agttcctcta tattcaagga catctcagca 2034901 taactgagtt tcgtaacagt atgaaggttc tcgaagcaaa tggagcagaa agcccggcat 2034961 atgagatgaa ttaacgtccg gccccctata aaaacgaaaa gaagacagcc ttttaccggc 2035021 tgtcttctct tgcaatttca tcctttactg cgtgcaatgt ataaaggact gactcagtga 2035081 tgtccttgaa tcgtttttta tgaatatgat gaacataaga ttgaaggacc aattccagga 2035141 aattatcctt tacggcctca atttgctctt tatgcacata ttttggccgg cggactttta 2035201 tcaattcaag agcaccctct gcccagcgag cagccagttc atcattctct tcaactgcag 2035261 gctttatcgt ctcaaaaaaa tcataagaat gattactgtt ttttccttcc tgataccgat 2035321 cagcgccttt ttcagcaact tcaatcattt gctcggtcat ttccagcaaa gtttgtgata 2035381 gcaatatctt tcacctcaat gcctatcgta ccaaatttca ctcacaaatt cagccgatgc 2035441 ggtatacctt ctcaaacgca tacctgtgtt caggcgattg atacagctca tttatacaaa 2035501 tatgaagatc tatgatttct tcttcgagca cacttaggcg atcgttctcc gtttcccgca 2035561 tctcagcctc taatgcattt acagaatgat tcaggctttg ctcagctcgc gttaattcat 2035621 cttctatatc agaaagcata cggagaatat ctgtcttgca tacataaccg gacattcgtg 2035681 tacctccctt tccttgtctc tcccggttaa cattctttgc tctcaaggct ctttccttcc 2035741 tcatgacaaa actagaagca aatcgccaaa caaacaggta ttccacgaaa agctgaagtt 2035801 ttcgacaaaa acacccgcaa aaattgtatg atcctcctca ttaatgcaaa cgatacttgt 2035861 gaggaggtgc cgtatgaaaa caagaccgaa aaaagccggc cagcaaaaaa agactgaatc 2035921 aaaggcaatc gattctttag ataaaaaatt aggcggcccg aaccgccctt ctacgtaaga 2035981 agcaaggaat ttccttgctt ctttattttt tcagccactg ctccaccgca aaaagcgcat 2036041 gaagctggcg ctttttatgt aaataccagt ctgtcaattc aatctgcttc ggcaattcct 2036101 cgcgcctaaa gaacgttttc tttatctttc catgaaacca atctgttttc gttccgtcta 2036161 atgagtggat taactcaggg tagcatgtcc ttagcatagg agatgttctt tttgtaatcc 2036221 cgatcatctt ttccatatca aaacgggaac ctgtgtgcgg cactgtgtgc aaaaagtgat 2036281 aaaaagagga gaacaattct ggcttgaaca gcaattgaga cagctgcttt cccagcctta 2036341 tcctttcctc cgcctttgaa aagcgtttca ctgaaatgcc gtaaaaaaac ccatttgagg 2036401 aaggaaaaat aacggtgtta aaatgaaacc agtcacttaa ataaaaagga atcgtgtcaa 2036461 aaacattctt tttaaacgaa ggattttgta taataggtgt ttggatagtg ttttgttcat 2036521 ttataatgag ggcatacatt agccgctccg tatttcgctc atgccaaaaa cgggtccatt 2036581 cttccgacat aaattgtgag acgccaaaca catgcagcag atgaaacagc ggtttcccaa 2036641 ctctttttga ccagtggtat aaaagaagct gcggataggc atccgaaaaa ataagccagt 2036701 tcgctctttc ataggctaaa aagaaccatt tttgctgtct ctcacggagt ccaagctgaa 2036761 acagactgcc ttttaagtca gtcattgacc agccggcatt acgagaaacg aaagaagcca 2036821 aaagcgacca tttgatttcc ggatgacggt cgtaaaatgc tttataagca tttgttcttg 2036881 aaatgttatc cgcgtttttc atttttgtct gccgctcaat ccggctcaga agctttctga 2036941 tggcctgttg ttcttgcacg ttcattcact tccgtcatga ttagtttaat aaggaggatg 2037001 agaaagtgat tcggtatcct aatggaaaaa catttcagcc gaaacattcg gtttcatccc 2037061 aaaacagtca gaaaagggcc ccgtcttaca gtaatcgcgg aatgaccctc gaagatgact 2037121 taaacgaaac gaataagtat tatctgacaa accaaattgc cgttatacac aaaaagccga 2037181 cacctgttca aattgtaaat gtccattatc caaaaagaag tgccgcagtg attaaagaag 2037241 cttactttaa acaatcatcg acaacagact acaatgggat ttacaaaggg cggtatattg 2037301 attttgaggc gaaagaaacg aaaaacaaga cctctttccc cctgcagaat tttcatgacc 2037361 atcaaatcga gcatatgaag caggtaaagg ctcaagacgg tatttgtttt gttattatat 2037421 ccgctttcga ccaggtttat tttttggaag ccgataagct gttttatttc tgggacagaa 2037481 aagaaaaaaa cggcagaaaa tcaattcgaa aagatgagtt ggaagaaaca gcttatccga 2037541 tttctcttgg atacgcaccc agaattgatt atattagtat tattgaacag ctttattttt 2037601 cgccatcatc tggtgcgaaa ggttgattaa cgaaaggttg agatgttatg tcagatcaat 2037661 ttaacagccg tgaagctcga cgaaaagcga acagcaaatc gagtccttca ccgaaaaaag 2037721 gcaagaaacg aaaaaagggc ggattgttta aaaagaccct tttcacttta ctcattctgt 2037781 ttgttttagg cgtagtcggc ggtgctgtta catttgccgt catggtttct gatgcgccgt 2037841 cccttgatga aagcaaattg aagacgcctt attcatcaac gatttatgat aaaaatggaa 2037901 aagagatcgc cgaagtcggc gccgaaaaac ggacctacgt ctcgatagat gaaattcccg 2037961 atgttgtaaa agaagccttt atcgcgacag aagacgctcg tttttatgag caccacggga 2038021 ttgaccctgt ccgtatcggc ggtgcattag ttgccaactt taaagacggc ttcggggctg 2038081 aaggcggaag tacgatcacc cagcaggtcg tcaaaaactc ccttctttca catcagaaga 2038141 cgttgaaacg gaaggtgcag gaagtatggc tttcgattca gctggagcgc aattactcta 2038201 aagatgaaat tttagaaatg tatttaaacc ggatttattt ttctcctaga gcatacggaa 2038261 tcggaaaagc ggcggaagaa tttttcggcg ttactgattt aagcaaattg actgtcgaac 2038321 aggctgcgac gcttgcagga atgccgcaga gcccaacagc gtacaacccg gtcaaaaacc 2038381 cggataaagc ggaaaaacga cggaacatcg tactcagtct gatgaaaaag caaggattta 2038441 tttctgattc tcaatataac aaagcgaaaa aagtggcagt gaaagacgaa ggcgtcgtgt 2038501 cacagaagga atatgaaaaa gcaagtacaa acaaatacag cgcatttgtt gaagaggtta 2038561 tgaaggaaat tgatgaaaaa tctgatgtcg atccatctgc tgacggatta aagatctata 2038621 cgacattaga tacaaaagca caagataaac tagatgaatt aatggacgga gacaccgtcg 2038681 gatttactga aggcatgcag ggcggtgtga cgcttctcga taccaaaaac ggagaagtcc 2038741 gagcgattgg tgcgggacgc aatcagcctg tcggaggctt taactatgct actcaaacta 2038801 aggcacagcc tggttcgacc ataaaaccga ttttggacta cggaccagtt attgaaaata 2038861 agaaatggtc cacatacgaa caaattgatg actcagctta tacgtattct aacggaaaac 2038921 cgattcgtga ttgggaccgc aaatatctag ggcctatctc aatgcgttac gctctggccc 2038981 aatcaagaaa tatacctgct ttaaaagcat tccaggcagt cggtaaagat actgctgtag 2039041 actttgcaaa tggactcggg cttggtttaa caaaagataa tgtaacagag gcctattcta 2039101 ttggcggttt cggtgggaac gatggtgttt ctcctctgac aatggcaggt gcatacagcg 2039161 cgtttggaaa taacggaacg tataatgaac cgcattttgt aaaatctatc gaatttaacg 2039221 atggcacgaa gcttgactta acaccaaaat caaaatcagc catgagtgat tatactgcgt 2039281 ttatgattac agatatgctg aaaacagctg tgaagacagg tactggacag cttgcacaag 2039341 tacctggtgt agaagttgca ggaaaaacag gaacgactaa ctttgatgat aatgaagtca 2039401 aaaggtacaa tatcgctagc ggtggcgccc gagattcttg gttcgttggc tacacaccgc 2039461 aatatacagc tgccgtctgg acgggaatgg gagaaaacga ggctggaaag aaatcacttt 2039521 cagctgaaga gcaaaaagtt gcaaagcgca tcttcgccca gctcatcgcc gatgtcgatg 2039581 acggaagcgg atcatttgag aagcctgaca gcgtagtgga agccaccgta gaaaaaggtt 2039641 ctaatccggc aaaactggca gggccaaata cgccaagcga taagaagctc acagagtact 2039701 ttgttaaagg cacagctcct tctactgttt ctaaaacata tgagaaagaa gaaaaagagg 2039761 aaacagctaa actgtctggt ttaaacgtga aatacgataa agacaatcaa tctttaacgt 2039821 taagctggaa ttacgacgga gatgcgacct ttgctgttaa gcaatctgtt gacggcggca 2039881 gctactcgga aattcaaaac agctctgcaa aagaggcagt tatttcgggt gtgcagccag 2039941 gatctgtata caaattcgaa gtaacagccg tcagtgatga tggcaaaagt acagcttcca 2040001 catcttatga ggtgccaaaa gctgaagacg atgaagataa aaaagaccag caacaaacgg 2040061 atgatgaaaa acaagatgat gagaagactc aggatgatac acaaactgat gattctcaaa 2040121 aagatgacgg tcagacggat caagatcaga cagatgattc aacaaacgat caagacaaaa 2040181 aacaagacaa tacgaacacc aatccgtccg acaacaataa ccaagaccaa tcaaacgata 2040241 atgataacga caacagtaac aaccaggata cgtcggatgg tgattcgaac tctggtaaga 2040301 atgattcaac aggttctgac acgaataaaa ataaaacaga cacatctaat aaaacacaaa 2040361 caaactcatc atccattgaa aaaacaaatt aaacaaaaaa gccgtcacct ttggggtgat 2040421 ggcttttttg gtacacaata aaaaacctcc cgttttaaca ggaggtttta tcgattcatc 2040481 gcatgatatt tataaaaatg ctttttcatt tcggtaatca gctcatcaag ctgaataaag 2040541 caatggtatt gggtcggctt aagaagaata aattccactc gttcagccca attaatcggc 2040601 tttgcgggat atgatttctc cctcagttct tgccaatcga gcgatttcac cggctcacct 2040661 gctgtccaat gtaacgaagc cagcaaacac acaatgccct ttaacatttc gttttggtca 2040721 catctcgatt ttcgtgtttg aaagactggg agaagtgatg ctttgatgtc atcccacact 2040781 tcaaataaaa gcggaacgta tttcccgctg tcctcccatg gcaaatcgcc ttgtaattcc 2040841 gtgcagaaat caaaatacac gggattggtc tgcaaggttt tcttcatatc cgaggaactc 2040901 ttctggccaa gactgcgcaa gtattgctca taggaagcca acacttcttt tgcttgcgtc 2040961 atcgtttcac cagtcctttt ttatccctct tctgcccttc tctgcacaaa gaaagcagcg 2041021 gacactccgc acagcgcgga gattgggctt tacagtgata tctgccgaag aaaataagcc 2041081 ggtgatgcgt aacggaccaa tcttctttgg gaaccttgcg catcagcgtc ttttcaactt 2041141 ccagaaccga gtccttccac cggcaaatgc ccaatcgttt gctgactctc tccacatggg 2041201 tatctacggc tatggccggc acgccaaacg caacggatac cactacgttt gcggtctttc 2041261 tcccgacccc tggcagtttg acaagctcat cgcggtctct cggcacttct ccgccgtaat 2041321 cttcaataat cattttactc agcttttgaa tatttttcgc tttattacga tataaaccga 2041381 ttgatttaat atcctgctga agctcttcca gcggaacagc caaatagtct tccggccgtt 2041441 tatatttttg gaataatgtt ttggtcactc tgtttacaag tgcatctgta cattgcgcag 2041501 ataaagcaac agccaccact aattcaaaag gattggaatg aaccagttca cactccgcat 2041561 gaggaaacat gtcacctatc ttgtctaaac agaattcaat ttgttttaga tttaacacga 2041621 ttgtcacctt ttcactttat tgttcaagcc aattgtaaaa aggaacctgc cttttatact 2041681 ctttttgcgg ttcattctgc tttgcttgta cacgccggaa tttttggctg tgtatttttg 2041741 cctgctccac agttttaagc ccatttttct tccattcaaa caaaatccgg tcaatgtagc 2041801 ggaaactgag ttttcctgat agtacagcct cttttaacgc gtgtttgatc agttgtgcgt 2041861 catgctgatc ctggtcctgc cagatcgcca gcgtttcaca ctccaaaggc gataacggtc 2041921 ttgcgaactc ttcctcaaaa atggtataaa ggcttttttg ttccccttct gcttttcttt 2041981 cctgtgtttg attctgtgca agctgaatat actcgtacag cttgccccat aaaggctgaa 2042041 gagaatattt ctcaaatttg atgccgtttt gatcctcgca ttcttcaata aacagaaagc 2042101 ctttttgaat aaacatccgc aatctgtttg tacattcttc aacagaaatt gacatacctt 2042161 cctgcagctg attcggtgta ggaaaatatg atcctttttc taaatgcatt ttaattttta 2042221 acagcagaat aagttctgtt tcattaagcc caagctgttt ataatgcgtg agcagaagat 2042281 tggggatggt tgatgttccc tgctcctgca tatcaataaa ttgctgtttt ttcatcgtca 2042341 cacctcttac tgtaaaggat tgtgattgcc cctttactgt aaaaagtctc ccttgcagga 2042401 gactcttttt tgtttcattt gaatgtatta cggatacaga cggtttaaca gtcttgggaa 2042461 cggaatcgtt tcacgaacgt gaggcgctcc gctgatccaa gctactgtcc gctctaatcc 2042521 aaggccgaag ccggaatgag gaactgatcc atattttcta agttcagcat accatttata 2042581 agcgtcagaa tccagtccat gttctttaag acgcgattcc aaaagttcca tatcgtgaat 2042641 ccgttcagac ccgccgatga tttctccata gccttccggc gcaatcaagt cagcgcaaag 2042701 cacaacgtcc tcacggtcag aagccggctg catatagaac ggttttaagg acgtcggata 2042761 gcgagtgatg aataccggtt tgtcataatg ttcagcaatc gctgtttcat gaggcgctcc 2042821 gaaatcatct ccccactcga tatcgtcaaa gcctttttct ttcagaaatt caatcgcttc 2042881 atcatacgta attcttggga acggggcttt gatttgctca agttttgacg tgtctcttcc 2042941 caatgtgttt agttcaattt tgcaattttt aagaactgat tgcacgatga aagaaacgta 2043001 attttcctgt acttgaaggt tttcttcaaa ttctacaaac gccatttccg gttcgatcat 2043061 ccagaattcg attaagtgac gctttgtttt agacttttcc gctctgaatg tcggtccgaa 2043121 agagaatact tttcctaaag ccattgccgc agcttccatg tagagctgtc cgctttgaga 2043181 cagatatgca tcttcatcaa agtactttgt cgcaaagagt tctgttgttc cttcaggtgc 2043241 gcttccagtc aaaatcggcg gatccacttt tacgaagcct tcgttattaa agaattcgta 2043301 agtcgcgcga atgatttcat tacggatttt catgatcgca tgctggcgct ttgaacgcag 2043361 ccataaatgt ctgtgatcca tcaaaaattc cgttccgtgt tcttttggtg taattggata 2043421 atcggtcgct tcgtgaatga cttcaatatc tgtcacagca agttcatatc caagcggaga 2043481 acgctcgtcc tctttgacaa tcccttttat atagagcgac gtttcctgcg tcactgattt 2043541 agctgtttgg aaaatgcttt cttccacttc cgcttttact acgacaccct gaataaaacc 2043601 ggtaccgtcc cgaagctgta aaaacgcaat tttcccgctt gaacgcttat tagcgaccca 2043661 agctccgatc gttacttcct cacctacgtg cttgtacact tggttgattg ttgttttcaa 2043721 catatttccc tccaaaacaa gaaagacatt cggaagctca ttgccccgcg aactctttta 2043781 tcatcacttt attatacccg ctcttaacta accgggtcaa tgcagataaa aagcggcttt 2043841 tctgtcagcc gctttttgat ctgttagcta tgtttttcta caaaacgctt gattctttca 2043901 atggcttctt caagaagatc taacgatgtt gcataagaaa gacggacatt ctcaggagag 2043961 ccaaatccgg atcctggaac aatcgcaact ttttcctcct cgagaagcgc tttaacaaat 2044021 tcatctacat ctttgaaacc gcaagattga gctgcctctt ttgcatttgg gaacaagtaa 2044081 aaagcacctt ccggcttcac gcagctgaac cctgggattt ctatgagctt tgcatagatc 2044141 gtatttaatc tatgttcaaa tgcttctctc atttcttcca atggctcaga aggcccgtta 2044201 taagcagcaa tcgctccgta ttgtgcgatt gatgtcgggt ttgacgtgct gtggcttgca 2044261 aggttcgtca tcgctttaat aatgtcttca gagcctgccg cataaccgat tctccagcct 2044321 gtcatgctgt gggacttcga tacgccgttt ataatgaccg tttgctcttt cagtctgtct 2044381 gacagctgtg caatggaaac atgtttcttt ccgccgtatg taagtttttc ataaatttca 2044441 tctgacacaa tcaagatatc atgttcaagg cacacttcac cgagcgcaga tagttcttct 2044501 tccgtataca tgacaccagt cgggttgctt ggagagttaa taacgattgc ttttgttttt 2044561 tccgtaattg catttttcag ctgctcaggc gaaattttga agtgattttc ctcaagccct 2044621 tctacataaa caggctttcc gccagcgagt ttcacctgct ccgggtagct tacccagtaa 2044681 ggcgttggaa taataacttc atcttcttca tccaaaatca cttggaaaag ggtatacaga 2044741 gcatgtttgg caccagtgca gacaataatt tgagacggtt tgtattcaat attctggtcg 2044801 cgtttaaatt tctctgcaat gctgtttttc agttcagcca aaccaccgga aggcgtgtat 2044861 ttcgtatggc cctcgttcat cgaacgcaca gcggcatcaa taatatgctg cggtgtattg 2044921 aagtcaggct cgcctgctcc taagccgatg acatcatggc ctgcggcttt cagttctttc 2044981 gctttcgctg tgattgccag tgtggttgat ggtgttaatg cggatactct ttttgccagt 2045041 ttcaacttga actcccccta attcgtctta aggcgtgata tttttgagaa tctttccagt 2045101 tgtaaagtcc acataactta aactgtattg cccttctttg tctaagtacg tcacttccca 2045161 aagcaggacg tttccttctc ttgccagatg aacctctttt tgctttgaaa ccagcccttc 2045221 atcctttatg attttcgccg ctttgtcttc agagattccc tctttcgctt cttttgagag 2045281 aatttttgct tttttatcag caggaaccca gacatataat gcagtgcctt ttttatccgt 2045341 tccctttaca acataatatt tttcttttcc gacaaatgtt tcgacttgat caacatgggc 2045401 gagatcggtt tcttttttag cttcagcagc tgctgcttcg tgcccctctt ccttttgtgc 2045461 catggctgat ttataaatgc ttgccgagac aagaagtact gctaaaaaaa taataccaaa 2045521 aatgacggta aatattaatg ctttttttct catcttctca cctacgtacg ataaatggta 2045581 aaaacggctt ggtttttgtt ttcttcatcc agcgcaaggc cgaacatcag attgtctctt 2045641 ttcagtgtac gattcaatgt gtccacaatt ttatacagat catcagaatg ctctacatta 2045701 attgttgaaa gaatttcgat tttactttcc attttttcat cctccagttt gaacaaatat 2045761 tgttagtcat actccatttc aggacacgcc atactagtat cacagagcgg gaaatccgct 2045821 tttaaataaa acaccatcct actcccacac cgcaaaagcc gctttatgcg gcttttattc 2045881 tttttcccct gcaacataag cttcaagctc gctgtcagtc atttcggata ctgaggttgt 2045941 cggcaaggca tcaagaaaca gccggccgta accagcggtt ttaatccgtc tgtccaatat 2046001 aataatcgtt cccttgtctc ccgcagaacg cagcaagcgt ccgattcctt gcctgaaggt 2046061 cagcacagct tccggtaatg acactgtttg aaacggattc tttccttttt tgcgggcaag 2046121 ctcacatttt gcagcatgaa gcgggtgatc aggggaccgg aatgggagcc tcacgatcat 2046181 tactgtcgtc agctcatcac cagggaaatc aacgccttcc caaaaatgat ttgttccgag 2046241 caggatcgcc tgattggatg ttttaaaagt cttcatcagt ttgccgggac ttccgcctgt 2046301 aatcccttgt gccaagagct gaatgccgga agcactcatg ttatgcttaa gctcctggtg 2046361 aacctttttc agcatatcat gggatgtaaa cagcacaagg attttaggct gtttttcctt 2046421 tgccatcagt tcgatataac gggctgtatc ctgtataaat tcaggttgcc ctgtatcctg 2046481 aattgatttc atttcttttg gaatcatcac ctgcatacgc tcatcgtaag aaaagggtga 2046541 ctcaattctc attgtccgcg ggaaaaagtc actcagtccc agtcgttcaa tcataaattg 2046601 aaaagaacct tcgactgtaa gagttgcaga tgtcagcacc acactatttt tgcgcgcgaa 2046661 aaactgatca gccagaagtt caccaggttc aagaggctgt gcgtaaatgg ccactgcatt 2046721 tttcgcaccc tttgcatcta tttcaatcca aaccgcttca tcgtcatcag agccaaagaa 2046781 gagcttctgc aacgtctgac agtaatgctg caagcctttc atgcttcttt ggtattcatc 2046841 ggctaaaaag acggttttgc tcttcatgcc cttcaaatgt ttttccataa gggatgactg 2046901 cgcctcaaaa agctgctgca aatgtgtcag catggaacaa agcctctccg caccatctgt 2046961 taagatcgac cagcttttat cctggctttc tttgttcacc ttaaacacta gacggtttaa 2047021 gtcttcttta ggttttcttc gtttgacaaa agaatgtaca gagctaaaga aagcatcact 2047081 ttctgcttga acgtgctgaa gccactcttc caattcgaaa aatgaatcaa ccggcaggct 2047141 gtttcgctgg aatagctgtc tcatcttttt tagaagtccc tgctccttca gagtgccgat 2047201 tctgctcaat ttcgtatgca attctatgta cgtggctctt ttccctaaat gttcgcttgc 2047261 cgcacgttca aaatggtgtg cttcatcaat aataaatgtg ccgctttcgg gaagcctttt 2047321 tttatggctg ccttcatcgg tcagcaaaag agaatgattg gtgatcacca aatcggaacg 2047381 catagcaatc tgtttggccc gctcgtaaaa accgatcaca tgctcactgc gacttctttt 2047441 ataggagtca tcgtcataag ccaatctgtc ccacagcaat tttccgcctg aaggcaaatt 2047501 cagttccgct acatctcctg tatttgtctc tgtcagccaa acaagaagct gtgcctttgt 2047561 cagtacggca tcataattat catcttcttc atgaagcacc tgctcaaatt tatacaggca 2047621 taaataatgc gattgccctt ttaaaatcgc cgctgttacc ggaaatggaa acagatcttg 2047681 gacaatcggc aaatcctttg tgagaatctg ctgctgtaaa agcgtcgaat acgtgctgat 2047741 tatgaccggc ttttttgatt tcttggcaaa aagcgcagcc ggaataagat agccaatcgt 2047801 ttttccgatg cctggaggag cttcaatcag cgcatgctca cgattggcaa acgcatcagc 2047861 cacctctctc atcatcatca tttggccgtc tcttttttca tacccaggca ttaactctga 2047921 cagcgctttt tcatttcccg cttcccagct ttcgatctca aatgagaagt tctcgtcctc 2047981 atttatacga acatcgatag cttcaggttc tctgacagaa aacgaagaaa agcgcgtata 2048041 gcccggtatc tcggtatgtc tgttttcatt aatgaacata tccaacaaat gcgtcagatc 2048101 actgatgaaa tgctgcgaaa gccttcttaa ctgctttaat gtcggataag gaagctgccg 2048161 cagcttttca aggatttcca aaaaaataag ccctgtcact tcagcatcgc tgtcagcccg 2048221 gtgcggctga tcatgccgca gctgaagctc ctcgcttaat tccgtcagct tatacccttc 2048281 aaatcccgga aaaacaatgc gtgagagctc gacagtatca agcacttcac aatctgggag 2048341 ctgaaagccc gccttatgta gctcatactt gacaaatcca aggtcaaaat ggatattgtg 2048401 ggcgacaaaa taagcgccgt caagcaattg gaatacttct tcagcaactg cttcaaatgg 2048461 ctgttcattc tcgaccattt gattagagat tccagtaagc tgctcaataa aagcagggat 2048521 tgatttattt ggattaatgt attttgaaaa ccgctcagta atttgtccat tttcgattac 2048581 aaccgctgcg atttgtatga ttttatcgcc tttcttcggc gaattccctg ttgtctctac 2048641 atctataaca acgaaccgtt gcttattcat taaaatggac acctcaattc ttgcatacga 2048701 caaaagtgta acacgttttg tacggaaatg gagcggcaaa accgttttac tctcaaaatc 2048761 ttaaaagaaa acccccgata aagggggctt ttcttctaca aaattgtacg ggctggttcg 2048821 ttccccagca tttgttcaat tttgttttga tcattcagaa cagccacttt cggctcatgg 2048881 cttgccgctt cttgatcaga catcattttg taggaaataa taatgacctt atctccttcc 2048941 tgcacaaggc gtgcggctgc accgtttaag catatgacgc cgcttccccg tttaccagga 2049001 ataatatacg tttcaagacg tgctccatta ttattattca caatttgtac tttttcatta 2049061 ggaagcattc ccacagcatc aatgagatct tcatcaattg taatgcttcc cacatagttc 2049121 aggtttgctt ccgtaacagt tgccctgtga agtttgccgc tcatcattgt tcgatacata 2049181 ttatattctc tccatttctc gaatatcaat aatgatatta tctattaaac gcgcttttga 2049241 aaaagcaact gcaacagcga gaatcatctt tccagcaatt tcattcacag gctcgagttc 2049301 cggataggaa taaagctcta catagtctat ggttccgcta gtcgtttcaa tgatatcttt 2049361 tgcagctttt atcaccgctt caggatctct ttcaccggct tggacaagtt ccgcacttgt 2049421 ttgaagggcc cgatacagct taggcgcttc ttttctttcc tcagctgtta agtatacatt 2049481 gcgagagctt ttggctaagc cgtcttcctc tctgaccgta tcgacaggaa ccaattcaat 2049541 atccatgaag aagtcgctga ttaacccatc aacaacagct acctgctgcg catcttttaa 2049601 accgaaatag gcacgagtcg gcttgactag attgaaaagc ttcgtcagta cgatcgcgac 2049661 cccgtcaaaa tgtccttctc ttgagcgccc gcataacacg tctgtgcgtc tttctacatg 2049721 aatcgtgaca ttcttttcac cgggatacat atcatgagca tctggcgtaa aaagaatatc 2049781 gactccggcg ttttctgcaa gagctgcatc ccgctcaata tcgcgcggat atgcttcaaa 2049841 atcttcatta gggccgaatt gtgcaggatt cacaaaaata ctcataataa cggcgtcgtt 2049901 ttcttgtctt gctttgtctg ctaaggttaa atgcccctca tgcagaaacc ccatcgtcgg 2049961 aacaaatccg attgacttgc cctctgaatg gtattgtttt atggcttctt tcagctgtga 2050021 aatatcagta atctgtctca tcttattttc ccccgtacaa gccgtcaagc actgtctggt 2050081 tcatttgaaa ggaatgcttt tgttcaggga aagcacgatg tcttacatcc tgaacatatc 2050141 cgctgattgc tgtttcgatg gtttcatcaa tgcgcgtata ttgctttaca aatttaggtg 2050201 ttctctcaac accgtggccg ataatatcat gataaacgag aacttgtccg tccgctttca 2050261 caccagcccc gattccaatg accggtatgc ttagcgtctc ggcaattttg gctgtgagtt 2050321 ctgccggcac acattccagc acaagcatca tagctcctgc ttcttcgcat tttatactgt 2050381 cttctattaa ttttttggcg ctttgttcgt ctttgccctg tactttatag ccgcccagta 2050441 cgccgactga ctgcggtgtc aaacctaagt gactgactac tggaatgcct ccaagcgtca 2050501 atgcgcgaat ggattcaaac acgccttctc cgccctcaag cttcagtgcg tcagctccgc 2050561 tttcctgaac gatagccgct gcatttttca gcgtatcttc cttagacagg tgataagaca 2050621 taaacggcat atctgtcaca ataaaggtat tcggcgcacc ccttttaacg gcttttgtat 2050681 gatggatcat gtccgcaact gtcacaccga cagttgaatc aaggccgagg acgaccattc 2050741 caagtgaatc accgactaaa atcatgtcaa ctcccgcttg ttcagcaagt ttagctgccg 2050801 gataatcata agcggtcagc atgacaatcg gttcttcaga ctccttcatt tttagaaaat 2050861 ccagttttgt tttcatgttt tctcctcctc atgtttagag gagatgatct gccgttttct 2050921 tctgcaagcc aaaaaacctt ccgttacaac gagaaggatt cttcactttc taaagttcgg 2050981 cgagtttcat ccctctgtcc cagtcctttt ttggatcaag gcagactgct gcaatgtcta 2051041 tctattttaa taataggtgc agttcgcagg cgatactgcc caatggaagt ataccaaaat 2051101 caacgggctt gtaccaacac attagcccaa ttcgatatcg gcagaataga tttttttaat 2051161 gccttcgttc gtttctaaaa gcagaacgcc ttcatcatct atacctaacg ccttaccgta 2051221 aaaggttccg tttaacgttc tggctctcat attagtgcca ataccgagcg catagctttc 2051281 ccataaaagc ttaatcggcg taaatccgtg cgtcatataa tcccggtacc gtttctcaaa 2051341 gcatagtaaa atatgctgga tgacgccggc ccgatcaatt ttttccccag cagcttggct 2051401 gaggcttgtc gcgatgtcct tcaattcatc tggaaaatca ttaggctgct ggttaacgtt 2051461 aatgccgatc ccaatgatca ctgaacgtac gcggtcttct tcagcctgca tttccgttag 2051521 gataccgact gttttttttc cgttaatcaa aatatcattt ggccatttaa tatccgtttg 2051581 gatgcctgct gcctcttcta ttccctgcac aacagctact gcagcaagca gagtcagctg 2051641 cggtgttttt tggagcggaa tgtcaggccg caaaatcagg ctcatccaaa caccgtttcc 2051701 ttcttgagaa tgccataccc tagacattcg gccccttccg gctgtttgtt tgtcagccac 2051761 cacaagggtg ccttccggtg cgttattatt cgcgagctca tgagccgttt tttgcgtgct 2051821 tgaaagaacg tcatggtaaa taagatgctg gcccatcact tccgttttta atccaaaacg 2051881 aatttcgctt tcactgagtt ttccgggttt tttgatgagc cgatatcctt ttcttctaac 2051941 ggcttctact tcataaccct ctttccgaag ctcttcaata tgcttccaca cagcagttct 2052001 tgaacagccg agagcatcac tgattttttg gccggaaata aattcattgc cggcctgaga 2052061 aaataattca ataaggtctt ttcttaatgt tgaccgcatg tcttcagcca ctcctctatg 2052121 tgtttctttt gattggagag cttccctgtc acaacagcct gctcgatcca ctgtaattct 2052181 tctgacaccc attttccggc cggccggttt cgaagcgcaa gcaagtcctt acccgtgata 2052241 tcaagatcct taaggctttt gatcggcagg ttttgataag cgtactgaat gtccttcagt 2052301 ttcttttcat ccagtttttc gttttgccga agctgcgata ttttggccgc tgagagcagt 2052361 gcttttttcc cagctctgta cattgtcatt gcgtcaaggc tctggccaaa cgtatcggca 2052421 atgtgaatgg cttccttgat cacttttccc gggagcttcc aggctttcag gaaaaggggc 2052481 gcgtctttca aaactatgcc aaggttaatt aaaagagcag cccaaagctc ctcacgggat 2052541 gttaaagaga agaatggaaa ctcactcgtt gaaatcaggt tttctcgttt atgataaaaa 2052601 ccaggaagct cttcatacaa tctcgtttga atgagtgttt gaagcgcctg gcgagaagct 2052661 cttccctgca gcaatttctc aaactctata gtttttcgtt cgactgaaac atgggagagg 2052721 agtgattttt ctttcgcaat ggcttcttct gtttccggtg aaagcgtaaa gccaagctgg 2052781 ctcataaagc gtacggctct cagcatacga agcgcatcct cttgaaatct atcctcaggc 2052841 tttccaacgg ttcgaatcac tttctgatca atatctttct tgccgccaaa ataatcaagc 2052901 accttcccgt ccgctgtcat ggccatcgca ttgatcgtta aatctctgcg ttttagatcc 2052961 tcttctaatg atgagataaa ttgcacttct gacggtcttc tgaaatcaac ataatcagat 2053021 tcagtccgga atgtcgtgac ttcataggtt tcatcctccc agagcacaat aatggtcccg 2053081 tgctctttgc ctacatcaac agtccgctga aacagccgtt ctacttgatc aggtgccgca 2053141 tctgtcgcga tatcgacatc tccgatcgtt cgtttcatat agctgtcacg aactgcgccc 2053201 ccgacaaaat aagcctgatg gcccgcttcg attaagatgc ggagcacggg aagtgctttg 2053261 ataaaaactt tttccatgtg atcactccgg ttctgctaaa tcggcataaa tctgttcata 2053321 ctggctgaca atttttttag aagaaaattc attttcaagc atctctattg ccgcctttgt 2053381 aaaacgattg cttagctgtt catcttctaa aatgctcatc gcgcgggctg ttgcggccgt 2053441 aacatcaccg acatccacca aaaatccgct cacattgttt tttataacct cagggatacc 2053501 gccaatgttt gttccaatac aaggcactcc gcaagccatc gcttcaagca ggacaaggcc 2053561 aaagctttct ttttcagata gcagcagctt caaatcgcta atagaataaa gatcttcaac 2053621 acggtcttga tttccaagca ttaagacttg gtcttccaag ccatattttc tgataagctc 2053681 gcaggctgtc gatttctccg gaccgtctcc gactaaaagc agcttcgctt tcgttttgcc 2053741 agcgatattg cggaacacac ggatgacatc ctgcacgcgt ttaacttttc tgaagttgga 2053801 cacatggatg acgacttttt catctggtaa aattccatgt ttctctttaa ttgccgctgt 2053861 gtttttcttc agatacacgc gctcgtctat aaagttataa atcgtttcaa tttttttctc 2053921 cggtttaatt aaatcgtatg tttcagccgc aagcgctgag gagacggccg tcaccctgtc 2053981 tgatgactca atagcaaaac ggatcagatc ttttagagac ggatcataac ctaacaccgt 2054041 gatatccgtg ccatgcaaag tggtaacaat gccgatattg cgtttcagca tttgttttgc 2054101 aagataggcg caaacggcat gcgggagagc atagtgagca tggataatgt ctaaattctc 2054161 ccgttccgcc acctcagcga ttttgcttgc caatgtcaaa tcatacggag gatacttaaa 2054221 aacagcatat tgattaacct caacttcatg aaaatgaata ttgggatgat atgtattcag 2054281 tctaaacgga atgcttgatg tgatgaaatg gatttcatgt cccttttcag caagctgctt 2054341 ccccagttct gtcgcaatga tacctgagcc tccaacgctc ggatagcatg tgattcctat 2054401 ttttagtttt ctcattgttc gcccccaagc acatcatgat caagcatcag catccgtttg 2054461 gaaaagaaac cttcggcata ctccacgccc gcttctttac cgtaaagctt ttctctcgct 2054521 tcaacgattt caatataccc attcgtcaga ggagtagaaa cggaatcctt tgacgggata 2054581 aactggcttt tgtaggcgtt gaggctttgt ttctttgcct ctattgtatc cgagatatca 2054641 ataacaaaat ccggctgatg aaaaccattt atcatataat agtaaacctt gctgacttta 2054701 tgcgccggaa ggcttttttc gtctttatat ttatggattc cggcggaaaa gatcgcttct 2054761 tccaccagtg cagccgcatt gccgtgatcc ggatggcgat cctttttata cggcataaaa 2054821 accgcttttg gccgacagat tctgatgaca gtgacaattg accgaattgc ctgatcactc 2054881 attattaggc cgcggtctgg aagcgttagc tgaattcttt tatctgcgcc taatatgcgg 2054941 gctgcttcag ctgcttcttc tttacgcaaa ctgaccgtac cgttagaaga gagttccgct 2055001 tctgtcaaat cgcatatcat tacttttttt tcctgtttga caaacttcgc tattgtgccg 2055061 cccattccga tctcgacatc atcactgtgg gcgccaaaag caagaacgtc agcattatac 2055121 attcggctct tctccccgaa gaaggtcacg gaattcgaaa acaccttcat caagtgtgcg 2055181 cacaagaatt tccgcagtac ccatatttgt ggcgagcgga atggaataca catcacataa 2055241 acggattaat gccgagacat ccggttcatg cggctgcgcg gtcagcgggt cgcgcaaaaa 2055301 aatgacaaga tcgagtgcat tggcagcgat cagtgcaccg atttgctggt ctccccctaa 2055361 agggccggat tgaaaacgtt caatttgaag acctgtcgcc tcatgaattt tcaaccctgt 2055421 ggttccggtt gcgtatagat catgattctt taaaatatcc cgataggcag tcgtaaattg 2055481 aaccatatcc tgttttttct tgtcatgcgc gatcaaagca attttcattg tttatccccc 2055541 cgtctaatca atgatatttt ctaaaccata cacaagctga tcaatcttca tgacttgttc 2055601 gactgacagt ttaacgcctg acatgaaaga agcacggtta taagaatcat ggcgtatctg 2055661 aagcgtttgg ccatccatgc cgaacatgac ctcctgatgc gcgatcagtc ccggaagacg 2055721 gacgctgtgc aagcgaatac cgttttgctc cgctcctctt gctcctggga gaatttcttt 2055781 ttcatccgga tgtccttgct gcttttcttt acggacttct gaaatcattt ccgctgtttt 2055841 aagcgcagtt ccgcttggtg cgtcaagctt ctggtcatga tgaagctcaa taatctcaac 2055901 atcctcaaaa tagttggcag ccatttttga aaatttcatc atcagtatcg caccgagcgc 2055961 aaaatttggc gcgatgatgg ctccgatccc tttttcttct gttaaagatg tgagctcttt 2056021 taaatcagct tctgagaaac cggttgttcc gacaactgga cggactccgt gctctaatgc 2056081 aatttttgta tgtacttttc cgatttcggg cgttgttaaa tcaatcaaga catccggttg 2056141 tgtttctgta aaacaggcat ggatatctgt gtaaatgaaa gcatctgact caacaggcat 2056201 cacatcagat aatttttgct gatcgtatgt atggtctatg gcccctacaa ggtcaaaatg 2056261 tggtgttcgt tctgccaatt taacagcttc ctgccccatt cttccacgcg gtcccgcaat 2056321 gactaattta attgtttcgt ttgacatctt gatctcctct actttccttc ttcttttctg 2056381 gtccagcgat ctttatctct tgtattaaat ttatgcatga ctcggtcgtg agcttcctct 2056441 aaagagatat caagagagtt ggctaaacaa accaatacaa atagcacatc gcctatttcc 2056501 tcttccatgc ttttatcatc ttcagtcgct ttttttggtt tttctccata acggtgattc 2056561 acttctctgg caagctcgcc cagttcttca gtcagcctcg ccatcatggc cagcgggcta 2056621 aaatatcctt ctttaaattg gcctatgtaa cggtctactt cagcctgtat gtctttcatt 2056681 gttttatcac tcactgaacg aaacctccta tcatcctctt acatgttagc taattcagat 2056741 acgtttgaca aatgtttaag cacgtttgct gttttctttt tcatccacta taatataaac 2056801 gctatctaat ggaaggaaaa ggggttttgt gtgatgcttg gagaaattag attaaaaaac 2056861 atatttttta ttttaatcgg agcggcaatt ttttcatttg gcttggttca tttcaatatg 2056921 cagaacaatc tggctgaggg cggttttaca ggtattacac ttttgcttta tgcccttttc 2056981 cacatcagcc cctctatatc gaacctggtg ttgaacattc cgattttttt tattggctgg 2057041 cgtttgctcg gcaggacaat gtttgtttat acccttgtcg gcactgtagc cttgtctttg 2057101 ttcctcagca tctttcagcg atatgaaatc catatgcccc ttcagcacga cttagcgctc 2057161 gccgctttat ttgccggcgt attcatcgga gccggactgg gtattatttt taagttcggc 2057221 ggtacgacag gcggtgttga tatcatcgca cgtttagtga ataagtattt tgggattccg 2057281 atgggcagaa cgatgtttgc tttcgatgcc tgcgtcatca ttttgtcttt gcttacttat 2057341 ctctcctata aagaagcgat gtatacgctg gtagctgtat ttgtagcggc aagattaatc 2057401 gattttattc aggaaggcgg atacgctgct aaaggcgcta cgatcatctc ttcgaaaaac 2057461 gacctgattc agaaaaagat tcttgaagaa atggaacggg gcgtcaccat tttgaaagga 2057521 caaggttcct acacaaaaga ggatatagat gtactttatt gtgtggtgcc gaaaaatgaa 2057581 ttggtgatgc tgaaaagcgt gattaactcc attgatcccc atgcctttgt agcggtaagc 2057641 gatgttcacg atgtgctcgg agaaggattt acgcttgatg aaaataaaaa tccgcttccg 2057701 cgctgacatg taatagaaaa aaggcggctg accgccgccc ctcatcctta tttagggtag 2057761 tccctttttt tcagcttgtt tttttccgcc ttgtactttc tgtaaccgac ataggtaaga 2057821 gcagtaatga tgatactgcc ggttgtaatg atcacccaga gtaaagacgg atcggcatca 2057881 tcctcctcca ccctgtcaaa cacatttttc aggtcatgct gaagaaggga aagccgttca 2057941 agcttcgtgc tctctgtcat ttgctgaaat tcctcttgct caataacatc tatatgtttt 2058001 ccgactgttt caagctgatc ctctgataca tcgattgtaa gactggggta aatcaagtca 2058061 tataaactga taaattcatt ccatttttca tgaaagcttg tgcttccatt cttttggaca 2058121 tctcgcttca gttcagtaaa agcttccata atcggttttt ccagtgagcc ccaaagcggg 2058181 tcagaccgat tgtcaaccgc atccatcagc attctgaact gcgcggctgc tctgagtttt 2058241 tgtgtgtctg atgtatcagc ttgctttaaa ctccgaacca tatcattata gcccaatgtg 2058301 atttgacgaa tttgggctcc cgttagcatg gggtcttgct gttttttctc agcggatttt 2058361 aatgtttttt caaaatactc caagacttga agcgcctctt catatttcgc ctgtcgggtc 2058421 atttgaaaga ctgtatcgga taaatcattc aattcctcga ggcttccccg ctctgcagcc 2058481 ttggcatttc cattataaaa aataagtgca atcaacaaac agatcgtcag ctttcgtttc 2058541 atgcaggtcc ctcccactct ctctccttac agaatatgaa gaaagggaca aggatagacc 2058601 aacattgtct ttacatcagc tcaagcttcg tttgcttttt tgagaccaca agaaagtaag 2058661 caagcgcgat tgaaaagata cttagccaaa atgttccgta tcctatttca gtcatataat 2058721 cagaaagcat agagtattgc ggcatcatat caaacaagta gtcaatgaca tcgttatgca 2058781 gtgtccagac tgcagcaatt gcaagatgcc aaaatgaaaa acgaaaatac ggactgtata 2058841 atacgccttg aactgccatt gcaaaatgcg aagcaattag catgtagccc tcccacggca 2058901 agtcaccagt tactgcaagc acaagaaaat tcatagccac cgcccatagg ccatacttta 2058961 cgagggtaac tagcgcaagc gcctctaaaa gcggagcatt ccgtttcatg agaaaggcaa 2059021 gcagcacaaa cagaaagaaa aacgttgctg tcggactgtc cggaacaaaa atcaggaaac 2059081 gggccggtgt ctccaaaagc tgcggcaagt accaatagta gccgtaaacc gttcccagaa 2059141 aattaatggc taagacaaga ataagcatcg gccgctgccc taatacatat tgaaaccatt 2059201 tcacatcgaa tcaactctca gtctgtaaaa ataatatgtc catataaaaa agctgacgcc 2059261 gggtcagctt ttgataataa aagtatatcc ttccatttga caattcacaa tacgttattt 2059321 tgcggttgtt tcagaaataa attttgcaag ttcttcgagc tgcttatcat ttcctttgaa 2059381 cacacccgcc ggcattttgc ctttcccttc tacagcgatt tttttgattt catccggttt 2059441 cagcccgctg tcaaccaatg aaggcccggc cgctcctccc tgaaggttat ccccatggca 2059501 agaaatacag ccctgttcct taaaaacctt atatccttct gcattggtgt caatgtcggc 2059561 ttcttttgta attttcccct gttcttctgc cttggcccag tcatgagtag caactgactg 2059621 ccacgtcaaa aatacagcag cggaaatggc cagaagcatc ataccgacag cgaccggacg 2059681 cttccacggc cttctttctg tccctctgtc taggaatgga gccaaaagca gggccccaaa 2059741 agcgagacct ggcataatca tggcgccgac cactgtaaag cttccggcgg cgtattcata 2059801 cttcaacagc tggtataaga aaagaaaata ccaatccggc agcggaatat aaccagtatc 2059861 agtcgggtcc gccatccgct ctaaaggcgg ctgatgcaca atcgtcaaaa cgagaaaacc 2059921 gatgagaaag acagctccaa ccatccattc ctttaacaag aaatttggcc agaaagcctc 2059981 tgttttaccc ggatactccg aataatcctt cggtatattc ggcttttttt cagccggtat 2060041 ccttgagtcg cctacaaatt tcatcccttt gccccggtgc atgtcatccc ctccctttta 2060101 ttcgcagatc aagagtttaa agcggtcctg aaatcccctg cttccggatc ataataaaat 2060161 gtgcagccat cagcccgaac aatgcggcag gaagaaaaaa tacatggatc gcaaaaaacc 2060221 tagtcagcgt ttgggcgcct acaatatccg gatgccctgc aaggagcgtt ttaacttgcg 2060281 ttccgatcaa aggcgtggct tcggcgatct gcagtccgac ttttgttgca aacagagcct 2060341 tcatatccca aggaagcaag tagcctgtaa agccaagacc gagcataaca aaaaagatca 2060401 gcacaccgac aatccagttc agctcgcgcg gttttttata cgcgccttgg aaaaagaccc 2060461 tcagcgtatg taaaaacatc atcacaatga ccaggctcgc accccagtgg tgcatccccc 2060521 tgacaatctg gccgaatgcc acttcatttt gcaaataata taccgattcc caggcatttt 2060581 tgatatcagg cacataatac atcgttaaaa acattccaga taatacttgg ataacggtta 2060641 caaaaaacgt cagtccccca aagcaataca caaacgcaga gaaatgatgg gcgggattca 2060701 catgttccgg tacttcgtga tcggcaatat ccctccacat cggtgtaata tcaagccgct 2060761 cgtctaccca gtcataaatt ttgttcagca tgtcaccctt cccccttagg ctttgctttt 2060821 ccaagataca ggaagccgtc ttttacttct tgctcataat gatcaagagg cgcaagcggc 2060881 ggcgtgccag ggacattggt gccgtccttt tcatagagtc cgtaatggca tggacaaaag 2060941 aatttattcg ggtttttagg atcactattc cagttcaccg tacaccctaa atgcttacaa 2061001 attggcgaaa gtgctacaat ttcatccccg tttttgaaga cccaggctga tcttgactct 2061061 tctgactcat accaggcatc gacttgatta attttaaaat caaagcgctg cggctctttt 2061121 gtcaactcat caacgctgac aacctgaacc atatcctgct tccctgtcga ttttaatacc 2061181 gggtcgagtg cgaagcgaac cataggcatg agcatactag ccgccataaa acctcctacg 2061241 cctgtgagcg tataattcaa aaattgacgt ctggatatat catgttttcc gcccatctct 2061301 tctcccccct ctaagtcacc cctgcaaact gactaaaata gaaaatattg caataactct 2061361 agacaccctc ataatatatg aatctctcag caaggtcaat atagccaaaa tattgtttat 2061421 aaggaaatgt aagtgttttt ataaagtgct ccataactgt aacaaaacgt tcaaaatttc 2061481 agcagtgcgt tcatccaata tttttctttt taaagagtca tttaaatgct ctaatggaac 2061541 agacgatgta acaatcattt tgcctaacgc atcctcagct ctccaacttt cgtcagatgt 2061601 gagcaggaca acatgcggaa attccgttat cagctcttcc cgcaaatcct taagcccttg 2061661 aacggttatt tcatttctat caacatatgt ataaggcgga agtaaatata cccgtccctt 2061721 taactgcctt tcaagttctt ctgagagaag ctgcgtaaac tcgcctttct ccgccgccat 2061781 tttaaaatgg ttattaaccc ttatgttaat taatggtatg acagcggtat caatgtaatc 2061841 cttagcttgt aaatagtcct tggcatcagt gattctccac ctcatcgttc tcccccttta 2061901 cggcaacaag ccttgcaatt cactgcaagg ctggtcatat tatgtgagct gatttaattg 2061961 gcgcgataat tgttcaaatg cctctttatc atgacgatct aacgcgtcgt caatgtcttt 2062021 taataatttt tctctttgga atgtggaaat agcgtgctct aaaatctgtt ccgccaatcc 2062081 ctgatctttt ttattctcaa aaaggttttt cggaatatgc gggttggact ccagcaccgc 2062141 cgcatattca ggtgagctgt aagccgaacg gaaattaagc tggataaaca aatcctgctg 2062201 tttatttaat ctaatatcat gaaaagattt ttccgcgtcg gtagtcatga cattctcttt 2062261 atagaaccgg aacggaactt cttcaacaca atgtgttgac attataatgc ctctcgggca 2062321 aaattcagcc tgctccacaa aatgaacctt ctccatgaga gaatcatggc tcattaagta 2062381 gttcaagatc caaacgcact ctcggcgctt taactgataa tggtttaaaa accaacggat 2062441 aaaatctttt ttctcattga cagaaacagg ggtctgcatg taattccctc ctctatcgtt 2062501 cgtataatct atatacttat atgttccaca tgaatggtta atattcctgc ttatctagaa 2062561 aattcatcct cgattcgcaa aatcgtttct tcaagctctt cattggctcc gtccatttca 2062621 agaacctttt tcaaaagcgg cagcgcttct ttttgaagac cttcttctaa taggaagctt 2062681 gcgtattcat ataagaaatc tctatcctcc cggtaatgaa gataggcagc ctcaaaggat 2062741 tgttttgctt cctcgtattg ctctaattca gtatatgcgc ttgcaagata ccaattgtat 2062801 ttaggatctt cttcaccgta gcttcgaacc tcttgaataa gatcaatgat ctgatcataa 2062861 tcctcttctt tgtgatacac ggcaagaagt gtatgaagcg cctcgacaaa gcccggatca 2062921 agcgcaagcg cctcctgaag cagcttcttc ccctcttctg acttcccgat tttcaaggcc 2062981 attttggcgg cataaaggaa aagttctttg ttatattcat catatctgat cccctctttt 2063041 gccgttttta atgcctcttc atacattcct tcagcttcat agcttttcga gagcggcata 2063101 taaagtgaag tataagatgg atcaagctcc tttaaatcag acagctgctt aatagctgtt 2063161 ttcacaagcc ccgcctgtaa ggctgtaaaa ccatagccga aaatcgtatt aggatcagga 2063221 ttctcatcga cagctttctc ataccatgga atggcatcct caaattcacc tgaggcactt 2063281 aacgattctg ccagtctttg atggacatta acgcccccga tctcactctg ctcctcagcc 2063341 gttgttttaa aatattgaac cgcttttgca taggctccct gagcaaagta aagttctccc 2063401 agtgcaaaat caataacagg ttcattgtcc agaatggact ttgcctggaa aagcttttgt 2063461 tcactgactt cgaataaccc ctgcatctga taaagatccg ccataagcag caaactttcc 2063521 ggatatgatg gatctgtttc cggaatagtc tccagcacag cgagggcttt ttcttcttcg 2063581 tcaatatcta ttaaaagttc agcgtagaaa ttcgtcagtt ctgtttcatt tggatataaa 2063641 tcatgtagat cactaatcag tgaaatggct ttttctacat cgccccactc gtaataaagc 2063701 tgggctgcaa tggctttatc ttcatcatgc agctgttttt cagccttcga gagcgtgttg 2063761 aggccttttt ctgtttcacc tgcttcaact aattttatgg cttcttgaat caatgtattc 2063821 aaatcggacc ggtcctttct tttcctatac aacatcaacc atacaaaaaa agctttattt 2063881 gttcgggtta atcttatcat aattcagacg aatgcccccg gcaaataaga tgcttctgta 2063941 cggaagggaa ttattgagtc ttattagttt accaaaagat cttgagatag aaaatgaaaa 2064001 aaggaagatc gccctctgta cagtaaagca gctctttgac ctgccggctt gtaagtaaag 2064061 cacatccccc cttttcgttt ttctatccgt tctataagac aagctatgtt ttttcgcctc 2064121 gaattatgat ctgcataaaa aatcctgaag taaaacttca ggattttttc gaaagcttat 2064181 ttaaatgctc gaagaaggtt ggataagaaa cgtgaatggc atccgtgtgc tcgatttcaa 2064241 tcggctcctc cgttatacag gaagcaatac caagcatcat tccgattcga tgatctccgt 2064301 ggctggacac tgcagcgccg cctttcaacg tttgtttgcc ataaaccttc attccatctg 2064361 ctgtcggttc aatttcagca cccagcttgc gaagctcaga aacaacagta tcaatacggt 2064421 ttgtttcttt cacttttagc tctgccgcgt ccttaataac ggtggttcct tccgcctgag 2064481 tcgcaagaag cgcgatgata gggatctcat caattaaacg cggaatgata tctcctccga 2064541 tttcaactgc ctttagagat gacgtttcta taatcaaatc tccataaggc tctgcaccgc 2064601 tatcagcaga tggtttgatt tcaagttttg cccccatgtt ttgaaggaca tcaataatac 2064661 ctgtccgagt cggatttaaa cctacgtttt tcaatacaat tctgctgttt ggaaccatcg 2064721 cgccagcagc aaggaaaaac gcggctgaag aaatgtctcc aggaacaaaa atatcagcag 2064781 ctgtcagttt ctggccacca gcaatggaaa cactcgtttg atcttcagaa agcttaacgc 2064841 caaaagcaga aagcatccgc tcagtgtggt cccgagattt atggggctct gttacagttg 2064901 ttgtgccctc agcctgtaat ccggccagca aaacagcaga tttaatttgc gcgcttgcaa 2064961 caggtgatac ataatcaatt ccttttaatg aagcgccgct cactgacagc ggtgtaaact 2065021 ctccgccggc tctgccgtcg attttagccc ccattttttt caaaggctca gtcacacgct 2065081 tcattgggcg tttcgcaatg ctctcatctc cggctaccgc gctgtaaaaa ggacggcccg 2065141 ccaatattcc gagcatcagg cgaatcgttg tacctgaatt tccgacatct aaaaggcttt 2065201 ctggctcttt cagggcatcg attccttttc cgtgaatcac gacatcgctg ctgctttgct 2065261 caatgtgaac acccattttt ctaaagcaat cgatcgtgct cagacaatct gctcccggca 2065321 gaaagttttt aactgttgtt gtgcctgccg ctagcgcgcc aaacataaca gagcggtgag 2065381 aaatggattt atcaccggga atatgtattt ctccatgtaa ggtctgcacc ttatctcgtt 2065441 tcattttttc cacctcaatc agcataaaaa gtttcatatt ccgcccgggc ttcaatgcat 2065501 tgttctgccc ttttgcggtc gtcatcagac tgaaaactga tccttaaaat cccgttaata 2065561 tcctctcgtg tttcgataat gcggatattc gtgatactga tgcgctccgc agctaagatc 2065621 gctgttatct cggatattac acccggatga tcgggtacat ccacatataa atcataaaat 2065681 gcaggtatcg ctcccttctg ccgaagcggc agcccgtcgc gataatcctt ggctgtttta 2065741 aaataacgaa atagattttc cgcatcttct tgttctacat atgtacggat cttgtcaatt 2065801 tcacgaatcc actcatcaaa acggtctaag attttatctt tattatgtaa taaaatatcc 2065861 cgccacattg ccgggctgct tgatgcaatc cttgtaatat ctctgaaccc gccggcagca 2065921 aaacgcttaa caagcggata caggttttcc gaatgatggg tttggtgaac aaggctagct 2065981 gctacaatat gcggaaaatg actgattacg cttgtaacgc catcatgctc ctctggcgac 2066041 atttccacaa aatgggcatt cgtccccttc agcaggtttt ttaactgttc cacagcttgt 2066101 ttgtccgttt tctggcctgg cgttaaaata taaaatgcat tttcaaacag gaactccttc 2066161 gcagcggcca ctcctgattt atgtgaaccc gccatcggat gccctccgac aaattgatag 2066221 cggctaggca gcacttgatc agcgtaatca accacttttt gctttgtgct tcctacatcc 2066281 gtaatcaaaa gctcatgttc aattcctgaa tgagccagct cttcaagcat aaccagtgtt 2066341 tgttcaacag gtgtcgcaat gattactgta gctgcctctt tcacaccgct aataaacgaa 2066401 tcagcacgat cgtctatcac gcctaatttt aatgccgcta ccgcctgttc atcagagatg 2066461 tcgattccga taatccgttt gccgggatga ttttttttga tggctagggc aatcgaaccg 2066521 cctatcaatc cgagaccggc gagcaatatt gtatctttca tttgattcat acgtcatcac 2066581 ctggtttata gactaaagag gtgatatttg atcacctctt ataaaatttc agctaaaatg 2066641 gcaagtattt cttcattttg ctcttttgtt ccgatcgtaa tccggagtga tgtcgggaaa 2066701 cctaatgcgt ttcctgaccg gacgatatag cctttttcca gcagagcctg aaacagttca 2066761 tcagcaggac gtttaaagtc aattaacaca aaatttgtct gtgaagggta gcactttaaa 2066821 ccatgagttt tcgcaaaatc ataatactgc tgaaggcctg cattattttg ctcgacacag 2066881 gaagcaataa acgcttgatc atcaagtgct gcaatcgccg cagcctggcc cagacggctg 2066941 gtattaaacg gctctctcgc cggctcaatc tggcgaatca ggttctcgtc agcaattccg 2067001 tatccgactc tgagcgctgc cagaccgtat gcctttgaaa atgtgcgcaa aatcatcaaa 2067061 ttggaatact tgcttaagag cggcacggtt tccgggtaat cctctgctgt tacatattca 2067121 taatatgctt cgtcaagaac gacaaggaca cgagaaggaa cgcgctccag aaatgcgagt 2067181 aattctcctt cagatgtata agtgccagtc ggattattcg ggctgcatat ccaaacgact 2067241 tgtgtctgtt cgtcgatggc ttctaacatg gcgtctaaat catgtgagcc gtcgggacga 2067301 agtgcaattt cacgtacttc agcaccttca ataaccgcat tatgtttata ttgcggaaaa 2067361 gtgggggcag cagtaaccgt gtttgtttta tcgtttaaaa atgcccggca gatgatctgt 2067421 atgatttcat cagaaccgtt gccgaaaata agtgatgttt cgctgacatt gaggtgctta 2067481 ctgagccttg tccgcaaagc ggcgctatac ccgtccgggt aaagggctag ctgttgaatc 2067541 tcatgatgaa gcgcctcttt tgcagcctct gaacagccgt aaggattctc gtttgaagca 2067601 agcttcacaa ctttatccaa gccatattct gatttcactg cttcaatcgg ctttccaggc 2067661 tgataaggct tcagctgttt taaatgttct ttgatacgca aatcagtcac ctcattttaa 2067721 actgtacaag ccgctaaacg ccattgcata atcctcaaac tcctgcagcg cctgatttct 2067781 cgtttcagcg ctgatgagcc ggtcctttaa ttcttctatt tttctgacga gcgcacttcc 2067841 cactacgaca ccgtcactaa tttcattcat ctttatgacc tgttcacggt ttgatatacc 2067901 gaaccctaca gcaaccggaa cagtgctgag attcttcaca gtacgaatga acgggtacac 2067961 ggatgaattg aactcattgc ggacaccggt cacacccaga gaagatacac agtagacgaa 2068021 cccctcggct tgttcaataa tggttttcaa acggctttcg cttgtcggcg caactaaaga 2068081 aatatacgtc acctcatggc ttttacattc ctcttgaagg ctgttgcttt cttctaatgg 2068141 cagatccgga acaagcagac cgtcaatatg attttcccgc agtaaagcga aaaagtattc 2068201 tttgttcaat tgtaacacag gattataata cgtaaagagg ataatcggaa tattcactcc 2068261 gttttttttc atttctccgc ctaattcgat tgcctttacg atattcattc cttgatcaag 2068321 cgcccgcttt gaagcccgct ggatcaccgg accgtctgca agcgggtcag agtatgcaac 2068381 accaagctcc aatgctgtgg cgcctgcttt ttggagtgac ttcgccagtt caatcgaaac 2068441 ctcaggaact ggatcgcccg ccgtaataaa cgggataaac aatttttctg atggttgaag 2068501 atccaattta aacatgggct ttcacctctt cttccaatac attcattaat gtgttgacat 2068561 ccttgtctcc ccggcctgat aaacagacga gaatgagttg accgcgatcc attcctttgg 2068621 cgagtttgaa tgctttcgct aacgcatggg cagattcgat tgccggcaaa atcccctctt 2068681 tttctgacaa aagctttaat gcatccaccg cttcttcatc ggttatactg tcataagtga 2068741 cacggccgct tttatgcaaa tatgcatgct ccggaccgat tccaggatag tcgagaccgg 2068801 ctgaaataga gtagggctca ataatttgcc cgaactcatc ctgaatgaga taagtcaatg 2068861 aaccgtgaat aacccctacg gttcctttcg aaatagtggc ggcatgaaga ggtgtatcaa 2068921 ttccttttcc tgctgcttca gcgccgatca gttcaacatc ttcatttaaa aatgcctgaa 2068981 acatacccat cgcattgctt cctccgccta cacatgccac tactttatca ggcatagtgc 2069041 cttcaatacg tttcaactga tccttcgctt cctctccgat cattttttga aattcacgga 2069101 ccacttgcgg ataaggatgc gggccgacaa ctgatccaat catataaaag tgatcctcac 2069161 aatgctgaac ccagtaccgg atcgcctcat ttgtggcatc cttcaatgtt ccgtttccgc 2069221 ttgttacagg cactacctcc gctccaagaa gcttcatgcg gaaaacgttc agagactggc 2069281 gggcaacatc ctcttcaccc ataaacacag tacaggaaaa gccgaatttg gctgcaactg 2069341 ttgcagcggc aacaccatgc tggccggcac cggtttcagc aatgattttc gttttgccca 2069401 tttttttagc aagcagcgct tgacctagcg cattattgat tttatgagaa cctgtatggt 2069461 ttaaatcttc tcgtttcaaa tagattttcg cgccgcctaa gtattcagtg actcgatcag 2069521 cgtatgttaa tgcagtcggg cgtccggaat agtcctttaa cagcttataa tactcttcac 2069581 gaaaagcggg atcatccttg atttgtttaa atgctgtttg tatttcatct aacggctgca 2069641 tgagtgtttc cggaacaaac tttccgccaa aatcaccgta tctgcctatt tcattcggat 2069701 atggatacat atcggttcat cctttcttct aaaagcctca tcagattctg atctttttgt 2069761 ccgttttttt caattccgct ggcaaggtca attccttctg gctgccattt caataggcgt 2069821 gtgatgctat ccggattcac gccgccagcg ataaagcagc gtttaccaat agccgcctgc 2069881 tgatattccg gcacacattc ccaagaaaat gcaacaccag ttccgcctct agaccctttt 2069941 acagatgaat caatcacaaa gccgtcaaca ttatctttaa agcgggctat ttcttgagtt 2070001 gtgttatctt gatggtgaag cgccttccat atttcacagc ctgtcagctt gcgaagagca 2070061 gcagcatccg ccggtttttc atcaccgtga agctgaatga cgtcgagctt caagctcttg 2070121 gcaatacgtg acatcgtctc tattgattca ttaacaaaaa cacctgcaac ctgtttttcg 2070181 acacgaactt ggttcagcca ttttttcaca tcttccggag atacttttcg tttgctttca 2070241 gcaaaaataa atcctaggta atcagcctgt gattccgccg caagctgcaa atcctttagt 2070301 gaccgaatac cgcaatattt taatgccggt ttcttcacaa cctcactccc taaacaaagc 2070361 atggattgct ttacgctgag aagtttgtct catcaatgat tcaccgataa gtacagctcg 2070421 tgctccatgt tctttgacaa atgttaaatg ttctaaagaa ccgattccgc tttcgctgac 2070481 aagcagtgat tctttcggag caagagatgc gatttgttct gtctgcatga tagaggtttc 2070541 aaaagttttt aggtttcggt tgtttatgcc gagaatatca ggcgtgaata ctttcaatat 2070601 ttgttctagc gttgttgcat catgaacctc cactaacacg tccatctcct tttcacctgc 2070661 ttcaagatat aattcatgaa ggtgtaaggg atcaagcact tcgccgatta acaatatggc 2070721 atccgctccg attcttcttg attcctccac ttgaagagaa tcaataataa aatcttttct 2070781 gagtacaggt atcgaaacag cgcgctttac gtctgataaa tagctgtttt ccccttgaaa 2070841 aaacggggtg tctgttaaaa cggaaagcgc atctgctttc gcagtttcat agtcttttgc 2070901 aatccgcaca ggtacaaaat tctctttaat aagccctttt gacggcgacg ctttcttcac 2070961 ttcagcaatc aacccgataa accgattcag gcttgccagc gcctctttaa atgaacgttt 2071021 ttcgaaaggc tgctctaccg gcagaaccag tgttttcact tcttctttct tttgtttgat 2071081 gattttttca agcatagatc tcttcctctt tctgctttag tcgttcaagc tgcgcggcag 2071141 cgcctccgct tgtaatcgtc tctaacgcca gctccgttcc ttccttcagt gaggcggtaa 2071201 ttcccgccgt gtaaatcgca gcacccgcat taaaagccgt aatagataaa gcggaactgc 2071261 tgcttttatt ttcaaaaata ttctgaatga gataagcgct ctctttcgga gactgcacct 2071321 gtaaatcttc aagtctgcca tttgtgaaac cgaaatcttc gggtgaaacg gtatactccc 2071381 ggcgctctcc gtcctttaat tcaatcacgt cggtcggtgc tgtaattgaa agctcatcta 2071441 aaccgtcacg gcttgataca aacataacgt gcttcggctg aaacgtctcc agtgcgcttg 2071501 ccatcagtcc agctttttca acagaataga ccccaatcac ctgacgcttc gcctgtaaag 2071561 gattgctgag cggcccaagc agattaaata ccgttctgaa acctagctct tttctagtac 2071621 ctgctacatg tttcatagac gaatggtaaa gcggcgcaaa aagaaatccc atgttgtttg 2071681 tttcaatgct gcttttgacc ttttcgggag tggtttgaat agaaacctct agctcctcta 2071741 aaacatcagc gcttccgctt ttagaagaga cagagcgatt gccatgctta gcgattttcg 2071801 caccagctgc cgaggcaaca attgccgagg ccgttgagat attaaaagtg gaaataccgt 2071861 ctccccctgt tccgcatgta tcaacaatat caggaagtcc atcgactgta agagcgtgtg 2071921 cccgcattgc cttcacaaaa cccgcaagct cttctggcgt ctccccccga tgagcaagaa 2071981 ttgacaatat cccccccatt tcagaaggag tcatttccgc tgccatcatc atattcatca 2072041 gcgtttcagc ctcaccggca gtaagggttt ttccgtcaac gcacaattgt agaaatctgt 2072101 tcatcagctt tatcctcctt gctatgaaac atgtcttctg caatatgaat cgttttcagc 2072161 agcgcaccgg ctttattaca gctttcttcg tattcggctt ccggaacaga atcagcaaca 2072221 atgccagcac ctgcctgtat cgatgcaaca ccgttcttta cactcatcgt gcgaatcgta 2072281 atacaagagt cgatattccc gtcaaaccca atgtaggcaa tacaccctcc gtatgtctct 2072341 ctcggtgttg gctcgagttc ttgcaaaagc tgcatggcac ggattttggg tgcgcctgtt 2072401 aaagtccccg ccgggaaagc agacatcagt gcatcgacag gatgaacccc ttttttcaat 2072461 cggcctgtaa ccaccgagat aatgtgcatg acatgtgaaa aggaaacaat ttttgtgaac 2072521 tccggcacag aaacagaacc atactctgct actctgccga tatcgtttcg ggcaagatca 2072581 acgagcatgt aatgctccgc tttttctttt tcatccttca tgagctcaac cttcagtctc 2072641 tcatcttcag ctttgtctgc accgcgtttt ctcgtaccgg caatcggatg gatttctaag 2072701 tgcccgtctt gaacgtgtat taaccgttcc ggagagctgc cgactatttc tctgtctagc 2072761 agtttcatat aatacatata cggcgaagga ttgacgatcc taagcactcg gtataactca 2072821 aaagcatctg cttttatcgg cacctcaaat ttttgtgata aaacaccctg gaagatatcg 2072881 cctgctttta tatagctttt gattttttct acatcagcca taaaagccga tttttcataa 2072941 ttagaagata ctgtctcaaa gctgggtgtc ttgtatgaat cagcagaaag aaacagctct 2073001 tttatgtttt tttggtccat cattttttca atgagatttt gaagctccag atgattttga 2073061 tggaatacat ccattttttc gttttttgtt tcctctccag tgagccttgc atattggata 2073121 aagtggacgt ttttggtttc atgatcatac gcaattaatg tccggcaaac aaacagcata 2073181 cacttttcca tgtctgtttc tttggtatgc gaaggaacag aaggctcaat cagcgggatc 2073241 atatcatagc ttaagtaccc gacagctccg ccgacaaaag gaatgccaag ctcaggtgtt 2073301 ttgattttgt atgtggtatt catccagttc agcacttctt ttagttcatt tcctgtgtaa 2073361 agagatttgc tgtcctgatc agcggccgaa aaacggccct gctcttcttt aattgtgaga 2073421 aatggattca ggccgataaa cgaatatctg gaccaagtgg atgtatcgtc cttgctttca 2073481 agaagatacg taatctccct gtcaagcttc tctatcattt gaatgggtgt cagtgtatcg 2073541 actgtgaagg tctccacaat cggtatcgtg tggtgggaca agctgtcctc taaaaatgcg 2073601 gaaatgtttg attggaaatt cattgctctc actccttatg gcaaggagaa tgagaagatg 2073661 gcatgagagg ataaaatact atataacaaa taaacccaaa agaaagactt cttttgggta 2073721 gaataaacat aatgtctcag ctcaactaaa ctcattctct gctaccctat tctctaactc 2073781 aactcattct aattgcttta tacacactct tgtgtatttc taagctgttc ttatcgtatt 2073841 acaattcagt attttttgtc aatgataaat cgggcctcaa tacgacaact ttttctaaat 2073901 atacatgtct gatctgatcc tgagggacat ctgtctggac cgtcatcatg actcttatgc 2073961 actttttcag accgcctgtt acgtccattt cctgcataca tgttaccggt acatactgcc 2074021 atcctgaaag ctcgcgaaca gcttttgccg ggaaaacagc gtgcaaatca ggtgtagccg 2074081 acagaagcat ttgaacaaca tcttccggtt ttgtatgatt ttcttctatg attttctcta 2074141 acagctgttt agttttttgt aaaatttctt cttcagtatc ccgttcaact gtagttgctc 2074201 cgcgaattcc gcgaatcatc atgatgtctc ctccaatcgc catttgttca gccagctctc 2074261 aagttcattt ctggaaaatg tatgatcagc aactttccct aattcgttga gcacaataaa 2074321 ctgaatcttc ccgccacggg ttttcttatc attcatcata cggttcaaga gaaccgaagt 2074381 ttccgtctct tttctgattt gacttggata acccaggctt tttagccagc tgaccaaacg 2074441 ttttctgtcc atttcacagc ctacagtctt ttcgcttata tataaagcaa actgcattcc 2074501 gagggctacg gcatcaccgt gagtgatctg cccatatcca tattccgcct caacggcatg 2074561 gccgagcgta tgcccaaagt ttaagtaagc tcttatcccc tcttcttttt catcctgctg 2074621 aacgacagac gctttaattg aaatgccttt aaaaatcatg tcattcagct gatcattagt 2074681 gatatcacgc agtgagtgga tattcagcag ctcctccaga aacgctctgt catagataaa 2074741 agcgtgttta atcacttctg ccattccgga cctaagctct ttttcaggca gagaacgcag 2074801 gaaatctgta tcatagagca cggctttcgg ctgataaaac gcaccgatta gattttttcc 2074861 aagcggatgg ttcacggcta cttttcctcc gactgcgctg tcatgcgcca agagcgtcgt 2074921 aggcatttgg atgaaatcaa tgccgcgcat aaaagtggca gccacaaaac cggcaagatc 2074981 ccctacaaca ccgccaccga atgcgatgat gcatgaggag cgatccatat gaaaacgaat 2075041 cgcttcactc tgcaattttg tgtacatgtc catggatttt gcctgctctc cactcggtac 2075101 cgtcactttt ttcacaggcc atttttcttg cagcaaatgg agcatttcat caccatacag 2075161 gcggtccact tcttcatccg tgacaaacat aatccttgtt aaaggcctgt ttaaagaggt 2075221 taatagttcg caagcctttt ttctgatacc ttgtccgata aaaacaggat atgacgagga 2075281 agcagtttga acatgcagtg tcttcattaa aattccctcg acagttttct catattctcc 2075341 acattttctc taatgcggtc aatttgatct aatccgaatt gttcaacgac tgcgttcgca 2075401 atttcccaag cgacagccgc ttcagcgact acacttgccg caggaacagc acagctgtct 2075461 gaacgttcaa tgctggcaga aaacggttct ttcgtttcaa tatcgacact tttcagcggt 2075521 ttatacaaag tcggaatcgg cttcatgact ccgcggacaa caatcggcat ccctgtcgtc 2075581 atgccgcctt ccagtccgcc aagtctgtta gtagcacggg tgtatccttt ttcctcgtcc 2075641 caaatgatct cgtcatggac ttcgcttcca tttcgccctg ctgcctcaaa tccgatgccg 2075701 aattccacac ctttaaatgc gttaattgac agaacagcgg cagcaagctt gctatccagc 2075761 ttgcggtcat aatggacata gctgcccacg cctaccggca ttccctcgac aatgacttct 2075821 actattccgc cgatggaatc tccgtttgcc tttgcttcat caatggcagc catcattttt 2075881 ttgcctgcct cttcatcgta gcatctgaca ggagactctt ccgttacacg ctgcaagtct 2075941 tcaattgacg tatactctgt tttttcagct ttaacagcgc caatttgcaa cacgtggccc 2076001 gccaccttaa tgccaagctc agaaagaatc tttttagcta cagcccctgc cgccactctg 2076061 acagttgttt cccttgctga agaacgctca agcacatttc tcatatcacg atgattatat 2076121 ttaattgcac cgtttaagtc agcgtgccca ggtctcggtc tggaaatctg gcgcttcatt 2076181 tccttttctt catcttctgt aatcggagcg gcgcccatga tttttgtcca atgcttccaa 2076241 tcgttatttt caactacgag agcaattggc gaaccgagtg tacgtgcatg gcgcaccccg 2076301 ctcataattt tggcctggtc tttttcgatc tgcatgcggc ggccgcggcc gtgtcctttt 2076361 tggcgtctgg caagctcaaa attgatatct tcctccgtta tgtaaagccc ggcaggtaca 2076421 ccctcaataa tggttgtcag ttgggggccg tgtgattctc cggctgttaa atatctcatg 2076481 acttcttctc ccttcatcgc attaacgctt ttaagtaaga ctactataac atatttttca 2076541 gcaaaaagtc agtctatctt ttttgataaa agaatgtatc ggctgggact aggccaaatt 2076601 tctcgggatt gaagatttgc tcggtgctgc cgacaaaaag aactccattc ttcttcaagc 2076661 tatgtgccat ttttaaatac agctcttcct tcgcgctttc tgtaaaataa ataaatacat 2076721 tgcggcacac gattaagtca aagtcttgtt cataacgatc cgccagcaaa ttgtgctttt 2076781 tgaatgtaat attctttttg atttccgttt tcacttcata acttctattt gcgttttgcg 2076841 taaaataacg atctttcaca gatagcggca cttcctgtaa agaccgctcc tgataaacgc 2076901 cttttttcgc tttttccaat gctttttcat caatatccgt cgctaaaatc tgatagcccg 2076961 gaagaccttt ttgctggtcc aaaagcatgg caagcgtgta tggctcctcc cccgttgagc 2077021 aggcggcact ccaaattttt aaaggcctag aggtcttgat taacggcaga attgcagtct 2077081 caagaacttc ccatctttta taattacgat aaaattctga aacattgatc gtcattctgt 2077141 ccaatgtttc atttaagaga gcttgatcct tttccaatgc cgcagcaaag tccttaaagc 2077201 tttggaaccc ctttttctca taaagtgacg ttagccttct cttcatttgt gcttctttat 2077261 atagtgttaa atcgactccg gttaattgtt tccatttcgt tgtaaatacg ctgtatgtat 2077321 ccatctctac tctcccagtc tcgctgtctt tttgtcctag tatagcttgt tttatcagga 2077381 aattgtattg tttcaataaa aaaatcagct tttcagctga ttttagatcg ttgggaaagg 2077441 cagaggtctg atgcacactg ccattcaacc ctttattcac tttaatgtaa acctttacaa 2077501 aacagaacaa aaaccggcgg cgttatatgt tgccggctct gttgcttatt ttcacaatga 2077561 ttaatagatc cagcctgcca taagctgctg atatgatact aattcttcat tcttaaagaa 2077621 aatgttaatc tcgcgttctg cactttcgag agaatcagag ccgtggatga tgttttttcc 2077681 gacaaacatg ccataatccc cacgaatcgt accaggtaaa gcttctttag ggtttgtttt 2077741 cccgatcagc tgtctcgtca cttcaatgac attttcgcct tcccacacca ttgcgaatac 2077801 aggtcctgaa gtaataaact caacgagctc tccgaagaaa ggcttacctt gatgttcggc 2077861 gtagtgtttc tcagccattt gttcagtcac tctcattaac ttggcgccag ctaattgtaa 2077921 gcccttacgt tcgaatctag ataaaatgtc cccaatgagc tgacgttgga caccgtctgg 2077981 tttcaccatg ataaaagtct tttccatcat attctccacc ccatcattat gtatgtatag 2078041 gctttcacac tgcacaccga aatcgtaaca tctttctgat aattaatcaa tccggggcgg 2078101 agaaatttct taatatctac aaaaattaaa attttctttt accgatatat tttgcgatgg 2078161 ctgcaagaga cgagcgtgcg cgccctcgag gaagcgtgtt taatttctga aaagctttct 2078221 gcagatacat ttcgcttact gccatagatg cttcaattgc atctgttttt ttgatttctt 2078281 caatgattgg ttcaagctgt tcctgcgttg tctcactgtt aatcaattta agctggtttt 2078341 ttaatgcagg atttttcagg gcatacagca ctggcaatgt gacgtttcct tgaagcaaat 2078401 ctcctcctac gggtttaccc agctcttcct cagttgaagt aaaatcaaga atatcatcaa 2078461 taatctgata agacatgccg acgtaatacc caaaccagta caatgcctta tgaatcttct 2078521 catcagctcc agacgcaatg gcaccaagct ggcagctgac cgcgatcaag agagctgttt 2078581 ttcttttgat acggcggaga tacgttctga gattttgttc catgttgtat ttgtctttga 2078641 tctgctcaat ttcccctaga caaacttcaa cgatcgtctg tgacaaaatc ctatgggctt 2078701 tcggttcgtt aattctcgtc atcatttcaa gagatcccgc aagcatataa tcgcctgtgt 2078761 acatcgcaat acgattgtcc cactttgctt tgattgtcgg ttttcctcgg cgaagctctg 2078821 catcatcaat gacatcatca tgaaccaaag atgccatgtg aatcatttcc agagtgacgg 2078881 cgacatattt aatcttatta atatcataat cgccaaacat gccagaaagc agcacgaaaa 2078941 caggccgaat acgtttccct ccggcctgca gcaggtgaag acctgcctcg cttaaaagcg 2079001 ggtaatcgga acgtacggtt tgttcaagtt ctctttcgat tacatcaata tcgtcattta 2079061 aaaaagagta ggccatttta aatttcatat cattcaccca aacatctgtg ttttcatttc 2079121 catccgatat gcgtggcagc gactccgcca gtaaacgaat gatatttaac atttttcagg 2079181 cccgcctctt caaacaggcc tgccagttcc ttcattccag ggaaatctct ggctgattct 2079241 tgaagccaag aatattcttt atagctcttc gcaaacagtt tcccgaaaaa cggcataata 2079301 tacttaaagt acataaagta agcctgtctg aatccgaaca tttccggctg ggacgtttcc 2079361 agacatacca cctgcccgcc cggcttcact acacgtctca tctctttcag tacagtcaag 2079421 taatcaggga cattgcggag tccgaagcca atggtgacat aatcaaatgt atcatcatca 2079481 aaaggaagct ccatcgcatt tccgtgcagc agttcaattt ggctgaatcc gccgtctttt 2079541 actttctgct cgccgacact cagcatattt tcactgaaat ccaagccctt gatctcgccg 2079601 cttttgcctg ccgcttttgc aagagcgatc gtccagtcag ccgttccgca gcagacatca 2079661 agtgcttttg cgccttcctt tacattcatg atgcgcatcg ttttgtcgcg ccatttttta 2079721 tgctgctgaa aactgatgac agagttcatt tggtcataat ttttatatat tttttcaaat 2079781 actccgtgta cgcgctgttc ttttgagtcc tgcataatgg tttacccttc ttccactttc 2079841 tgatgatagg tttgatcttg gctgattgtc ttcagacggt ttattaaaat gttctgaata 2079901 ggtgaattta gaggcagaag tgactcaatg ctgtttttcg cttttttaaa acaatcttct 2079961 aatatctctt cttttgtttt tcccagctgt ataaaactgc cgatcacatc cagaaatgca 2080021 tcatttccgt tcataagccg cttaaataca aaaaaatcac tcgacagctt tttccagcgc 2080081 gggaggttga agtgttccgc cacacgatgg aataaagctg attcaacgat gccgacactt 2080141 tcgaaaaaat cgttttcgtc cttgaaagaa cggtcataca gacgaatttt atgttcgttg 2080201 atttctttaa tggctgtagc aagcgtccga atcatgtaga tatccttcat ttcagatagt 2080261 aaagagtagt acagcccgct gaaataatcg cccgcgagaa cagtcaattg gcggtttttg 2080321 ttttcgtctc gttttatgac tctagctgtc gtcacttcat catgggtatc aagggcgctt 2080381 tgtacaagca tcgctgttac aatataattt tctctgtcgt tgttttttat gtcggcttct 2080441 tcaaataaag catgaaaaag aagaagctta tcctcatcaa ttttcggcgc agaaatatgc 2080501 ttcgctaaat aaggatgaga cagcttttgt tttaatttcg tgttcagatt ggctaaagtt 2080561 ccgtagatgt cttgcaaaaa tatcaccctt gtccccaaat tcacatttat ttcttaatct 2080621 atgtatgagt tttatctttt cattcgctta cgcaggtatc attatagcat aaaaaaaaga 2080681 aattggctgt atcctcccgc tgtttgcgag catttgcttt taacagcggg gacagccagc 2080741 ttattttttt tcgcttttca tttctccgta cgcggtttga atcagtgcct ctcctctgac 2080801 tttaatggca gaagtatgct ctgtaaactg agcgatgatc acttctccct tgtcgagttt 2080861 ttcggaatgg tgaaactttg tgtctgttcc tcttgtcagg ccgatcacat tcactccgtc 2080921 ctcaacggct ttaatgacga caaaatcact tgaatgcttt tggttcattt atagcaccct 2080981 ctatctttat tagtcctggc gtttaatatg ttccaatact tctgcacggg cagcggcatc 2081041 atctttaaaa acgcctctga ctgctgaagt cacagttttc gcacccggtt ttcttacacc 2081101 gcgcatcgtc atgcacatgt gttccgcttc aaccactacc attacgccat gcggatcaag 2081161 cgtttctacg atgctttctg caattgtaga agtgatgcgt tcctgaagct gcgggcgctt 2081221 tgcaacggct tcaacggcac gtgccagttt gctgagtcct gtgacctttc cgcctcgcgg 2081281 gatatatgca acatgtgctt ttccataaaa gggaacaagg tgatgctcac acatagaatg 2081341 aaacgctata tcttttacaa gaacaagctc ctcatggttt tcaccgaaga tagtctggaa 2081401 atgttctttt ggatcttcat tcaagccgga gaatacttcg gcatacatct ttgcgactct 2081461 tttcggagta tcaagaagcc cttctctatt cgggtcttct ccgatcgctt ctaaaatttg 2081521 acgaacagct tgttcgattt gctctttatt aacttctttc atgttctatg tcctccacca 2081581 atgaatacat ttaatttcga ttctagcaca tatgccccgc taaaagcaaa gtgaatgccc 2081641 tgtcaggaag cccatgctct tgaaatatga aaagcccctt agaaaggggc ttttctgtga 2081701 agaaataaag tgtatgtaag ctagatgcat acacgatcta tattcacaat tattttccgg 2081761 caactgcgtc tttaagcgct ttacctggtt tgaaagcagg tactttgctt gctggaattt 2081821 cgatttcttc acctgtttga ggattgcgtc ctttacgtgc agaacgttca cgcacctcga 2081881 agttaccaaa accgatcagt tggattttat caccgttttt aagtgcatct aagatcgtat 2081941 caaaaacaga gtcaactgct tttgtagcgt cttttttaga caattcgctt gcttctgcaa 2082001 ccgcattgat aagttctgtt ttgttcatgc ctttcacctc ctcccaaaag gatacattca 2082061 gttcgtttat tatcatttct tcacagttca gtctgattct aaacctgtct cagaaaaaaa 2082121 tgagagcaag taagagaaag acaattaaac ggctttttaa gaaaaactgc actctgagga 2082181 atgtttgtcc aacaaagtga agaatttctg tatgtagagt aacacatata aaaagccata 2082241 tcaagcattt taaagcgtca atcccttgct cgtcaaggat ttaaggtgat ttaccgaacg 2082301 aatattcctt tttttccttt tttcatccta ttccttgatc cttttccatt attaagagca 2082361 aagaaaaaag acctcccatt ctataaagag gtctaccggt attacaggat gatggcgatt 2082421 aagccgccag agccttcgtt tatgattctt tctaatgttt cttttaattt ataccgtgcg 2082481 ttttcaggca tcaatgacag ctttgcctga atcccttctc tcacaattga gctcagcgac 2082541 cttccgaaga tatcggaatt ccagatggag agcggatcat cctcaaagtc ctgcattaaa 2082601 tagcgtacaa gctcttcact ttgtttttcc gttccgataa tcggggcgaa ttcgctttcg 2082661 acatctactt tgatcatatg gatcgacgga gcgacagctt tcagcctcac accgaatcgc 2082721 gagccctgcc ttataatttc cggctcatcg agactcatat cagctaaagc aggcgctgca 2082781 atgccgtatc ccgtctgttt gaccattttt aaggcatcag acacttgatc atattctgtt 2082841 ttcgcatggg cgaagtcttg catgagctca agcagatggt ctcttcctct gatttcgacg 2082901 cccacaactt cttttaggat ttgatcatat agatgatcag gcgcgtacaa atcaatttct 2082961 gccacccctt ggcccagctc aattccggct aatccggcac tttcaatgaa ttcaaactcg 2083021 ctgaattggc cgacaaccct gtctacgtcc cggagccgtt taatatcctt aaccgtttcc 2083081 ttcacggact cctgatagct ttcacgcaac caatggtttt ctttcagcac cattacccag 2083141 cttgggagat tgacattcac ttctagcacc ggaaactcgt agagggcctc tctgagcaca 2083201 ctcagcacat ctgattcccg catgctctct acactcattg ccaataccgg gatatcatat 2083261 ttttcgctta aatcctggcg catggcttcc gtttccgggt gatacggcct gactgagttg 2083321 atgaccataa taaaaggttt gccaacctct ttcagctctt caatgactct ttcttcagcc 2083381 tctatatagt cacttctggc gatatctcca atggtgccgt ctgtcgtaat gacaactccg 2083441 atggtcgagt gttcttgaat gacttttcgt gtgccgattt cagcagcctc atgaaatggg 2083501 atcggttctt cgtaccaagg cgtattgatc atccgcggcc cgttttcatc ttcatatcct 2083561 ttagcgccgg gcactgtgta acctacacaa tctactaatc ttatattcac atcgagtccg 2083621 tctgacacat gaacagacat cgcctgattc ggaacaaatt taggctctgt agtcataatg 2083681 gttttgccgg ctgcgctctg cggcagttca tcctgcgctc gggcccggtc tgcttcgtta 2083741 ctgatattcg ggagcaccac aagctccata aattttttaa tgaacgtgga ttttcctgta 2083801 cggacagcac ctacgactcc taagtatata tcgcctcctg ttcgttcagc gatatccttg 2083861 aaaatatcga ccttttccaa gtgatcccct cccggacttc ctatcctttt caattttatt 2083921 aagctctttc aatcaaacac aggacactat atgtgtatga cgttgtccta tttgaatatg 2083981 acatctttag aaaatttctc atcctcaatc tattaatata aaaaaacctt tctccctatt 2084041 tgtatgcaag ggagaaaggt tcattccttt ttcatatcat tttctaaaaa aacaggttcc 2084101 tgtttgtcat ttaccgtata ttttacagaa aacgcgggga caaagggggt ttcatgccaa 2084161 atcatatcct ggatttcagt cccgggttta aacgtttttt tgcttttttt gaggcaagaa 2084221 gccagctcag tccggtaatc ggcatatatt tctccgtctc cgtcaatcat aagcggcaag 2084281 gaattccctg agattgggct tgtcactgta agagagctgc catccccaag cttcttctca 2084341 tcgagtgtaa ataaatcacg agatagcaca tccttgtaag gcggatattg atgctcctga 2084401 cgatacattt ggatgcgcaa tttcacatcg cgaatttttt ctgccatctt tagatcaatt 2084461 aatttaacag tcggatcgtt ctctacgtca acaagcacgt attgatagtc tcccccgctt 2084521 tcaaatgccg tacttggagg ttcagctatg tatcttggcg ctaaccggtt aaagtctatc 2084581 ggatattttt gatatagcgg tgtcgacata tctttggttt gaataggaag cagccctcca 2084641 tttgcctttt gaaattcatc aacagcagat tgaacctgct ttagctggtc ttgataagga 2084701 atggcatgca cactgctttt ccgttcattt ggatataaac atccggataa aaacacgact 2084761 gccgcaaaaa tgattgcgca cttcagttta cccatacagc acttcctttt acagctttat 2084821 tcattgacag ggccgctaaa aaccacgaca aacacaataa ttccagatat gagcatacac 2084881 atgtatgcga atgatgaaat cgcaatcttc aaaaaacggt tttggcactt aaagcggctt 2084941 aaatagatgg aagctacagc cagaaacatc agacccatgg accctagagc aaaccacatt 2085001 ttcatcaatg ccagattcaa tgacgtgcgc ctccccgata tgtaagatat aagcgttata 2085061 ttatatttta atatacagcg ccggaaaaga tcaaccagat tttccatcca ttgatagaac 2085121 aaaaaaactg aagcaaagag ggggaccttc gcttcagtca acttgactat attcacctgc 2085181 acgtttaaga aacactctct tggacttcga tgctatagta tgcgacttgg catacagatg 2085241 catcctctat tgcctaaatc ggcaaaatgt ttcaggagat cccaagactt gggtgttctt 2085301 ctgtttttcg ggctttcgtt caattaagat atgcgattca ccatttgatt gacactttta 2085361 cttcacttga ttttcaaacg tatttaccaa atcctccatc tcgtgggttt tccctctcgc 2085421 cattaaagat tcaacagcgg tttccacttt ttgtccgttg aataggacct gatggagagc 2085481 ttctgtaatc ggcattttaa catcatattt cttcgaaagc tgataagccg ctttcgtcgt 2085541 gcggacgcct tcgactacca ttcccatctc ttcaagaaca tcttcaagct tgtacccttt 2085601 tccgagcaaa ttgcccgcac gccagtttct ggaatgaaca cttgtgcacg tcacaatcag 2085661 atcgcctact cctgtcaatc cagagaacgt caagggattt ccgcccattt tcgttccgag 2085721 tctcgcgatt tcggcaagtc cgcgtgtaat caaagcagct ttggcattgt caccgtaccc 2085781 taaaccatct gtaattcctg cagcaagggc aataatattt tttaaagccc ctccgatttc 2085841 aactccgata atgtcaggat ttgtgtacac ccgaaaattg tgattaataa atagatcctg 2085901 cacctcttct gctgccctca tgctctttga agatgcagta acagttgtgg ggtgccgcag 2085961 ccctacttct tccgcatgac tcgggccgga aaggacaacg atatcttttc tgacatcact 2086021 cgggagctca atttccataa tttcagaaat gcgcagaagt gaatctggct caataccctt 2086081 gctgacatga acaaagactg cctttttcgt tataaaaggg acagcctgtc tcagcacttc 2086141 ccgaattgct tttgtcggga ccgcaacgat aatgacatct gcgtctgaaa cagcctcttt 2086201 catatctgtt gttcctttaa tggatgtaga cagcttaaca ttcggcaaat aatctttgtt 2086261 ttcatgcaac tcattaattt gatgaattaa atctgcacgg tgagcccaca cacacacttc 2086321 atttccatta tcagttagaa ctaaagccag tgctgttccc caactccccg ctccaagcat 2086381 tgtgactttt ttcatgtttg attcacacct ttttattttc tagctcttgc aaatattttg 2086441 attggtgtcc cctcaaaacc gaacgcgtct ctgattcggt tttctaaaaa ccgttcgtat 2086501 gaaaaatgca tcagttccgg atcgtttaca aacacaacga agcttggcgg ctttaccgac 2086561 acttgagtcg catagtaaat tttcaaacga gaaccgttat gagtcggtgt cggattcatt 2086621 gccacagcgt ccatgatgac atcatttaag acgtttgttt gaactcgaag tgaatgattt 2086681 tcactagctt tgataatcgc aggcatcaga gtatggatcc gttttttcgt taaggcagac 2086741 ataaatagga ttggcgcata atccagaaat tgaaaatgat cgcgaatatt ttcttcaaat 2086801 tctttcatcg tgctctcatc tttgtcaaca gcatcccatt tgtttacgac gatgacgacg 2086861 gccttgcccg cttcgtgtgc ataaccggcg atacgcttgt cctgttcaat aatgccttct 2086921 tcgccatcca gcacaaccgc cacgacttct gagcggtcaa tcgcttttag cgcccgcagt 2086981 acactatact tctcagtcgt ttcatagact ttcccttttt ttcgcatacc tgcagtatcg 2087041 acaatgacaa actcctgctg gttgtaagta aatgacgtat caacagcatc tcttgtcgtt 2087101 ccagccacgt tgctgacaat aacgcgttct tcgccgagca tcgcattcac aagtgaagac 2087161 tttccgacat ttggacgtcc gatcagacag aattgaataa cttcttcatt gtatttcgtt 2087221 tcaggaatgt ttttaaaatg ctctgcaacg gcatccagta aatcacccag tccgagtccg 2087281 tgtgttcccg aaattggata cggctcgcca aagcctagcg aataaaaatc ataaatattc 2087341 gctctcattt ctgtgttatc cagtttatta accgctaaaa caacaggctt ttttgtgcgg 2087401 tacaaaattt tcgccacttc ttcatcagca gctgtcacgc cttcacggcc gttcaccata 2087461 aaaataatca cgtccgcttc atccatggcg atttcagctt gctggcgaat ctgcgctaaa 2087521 aacggctcat caccgatatc aataccgccc gtatcaatca aattaaaatc ataattcagc 2087581 cattcagccg agctgtatat ccgatccctt gtcacgccag gggtatcttc tactattgaa 2087641 attctttctc ccgcaatccg gttaaagatt gtggattttc ctacatttgg tctcccgaca 2087701 atggctacga caggtttacc catagtaccc ttcctttcaa tccagccgct ttcattttta 2087761 cataaatttt caaccggtta ttaaaatcat ttcattcact tttatgaaaa gaaacccttc 2087821 agaggaaggg cttaactcat ttattatatc agtttttact gggatcacaa ctattcttaa 2087881 aaatgtttca cgatcaaata cacgtcatct ccgattctgt gagctattcc atcaaggatc 2087941 gcctcaagat ttttagcgaa aagctccatc tccttttggt cattgcaaaa aaagacaggt 2088001 gctccccctg caacccgatt tcgatttgtc gtgattacag acaaaatcac tttcgtaaga 2088061 gattcactca tcctatcacc ttatcctgat tcttgataaa ttcagtcggc attctaatcg 2088121 cattttccag ggttggaaca ttgctaataa tttgaacagc cgtttcggga tggtgaattt 2088181 gcgggagaac aaatactgcc actctcccat catttaaatc ccgttttgca attggtgtca 2088241 aagatggctc tcctgaatcc cgataaaccc cgagcacatt ggaaacatca aataaaatgg 2088301 cctgacgctg ccctaaattt gctatcgtcg ctgctgaatt aaagtttttc ggcgtcaaaa 2088361 taaagcccat gccatgcttt aaaatcagtt cctgtttctc tggaagcccg atattcatca 2088421 tataaatatt atcaacaaac agtcccggac cgtcaaagcg cggctttatg tactcgatat 2088481 ctacaatatc cttcaacaca ctgcccgaca taaacttcat ggccagtaaa aaacaaacga 2088541 cagccgctat gactgcagcc cagatggata aaaacacata cgcagaggtt gtcaaaagcg 2088601 ctgtaaagat cacaatataa tttctgcttt caaacgcaat ggcaatcccc tcaatatatg 2088661 tgcttcccct tgagacaagt tcatacgaat ccatttgcgt caatgtgttc cgctccatgt 2088721 ttcggacatc tctaaattgc gtcgctgcca atgttaaaaa tgtgatggcc gtaaattcct 2088781 cctgcaaaag cgccggcata ataattgcac ctaaaccagc cgctatcaac cccagtgcga 2088841 tgtgaatcac tttcccatga acataggtcg gatactggcg gtaatccgtt ttcagcatat 2088901 aaagccttgt cgcaattccg gcaatgaccc cagcaataat cggatagatg taatcactca 2088961 tgacattttg gtagctcctt tgtttgatct tttgcttttc tgaccaatct ggcttgcgag 2089021 gtgttcgtat ttagatatgc caaacagcaa tatcatcccc gcagaacacg cattcagcca 2089081 ttgaaagccg ccgacagcca tagccccggc caacttctgg atcacaaatg aatacaccag 2089141 ttcgccttgg cacatcccta ggacaaataa gacaagctgc ttctcaaaat tcctttcaac 2089201 agaagctgtt aaaagcacta ttaatataac agcagcccac tcaggtttta tgatgaacca 2089261 aaccgggtca tataatgcaa aaagataaac aaacgcatac gcggcaacaa gcgtcagata 2089321 gaccatgatg taacgaaaac gatacattcc caaatacccg gcatagacac atccgcaaac 2089381 gaaaaacatc aaatatgcag cattcaggga aaaatataaa gcgatgtcat gtatgcttag 2089441 aataatatta gttaaaataa agacagagac ggcaattcgt cttttcgtct tttcaaaaat 2089501 aaatgttgtc agaacccaca gaaaccacat tgaccaatag taataaaatt gttccatttt 2089561 acttcctcca tattcccagt atggagttca agcacatttt ttaaacaatc gatctcacat 2089621 taaggagtat gatcatggga aaagacagac aagagaaaaa actcaaagct tcaggcagag 2089681 tcgaatcaga tcgcgaccag tccattcact atgacggagc gacaagcctt gaacaaaacg 2089741 gaagattcaa aaagcgaaaa tcataataca aaaagcccaa accacatatg gttttgggct 2089801 tttatcattt atcgcacact atagcttgat gtattgaccc ctctctctgt gagccaatga 2089861 tgggtttcac ctttgatcac aaggggcgcc ttttgtaaat cggcaattgt tctggcaccc 2089921 agcacggtca taatcaactt taattcctca aggatcagct gaatctcctc aagcagtcct 2089981 tcctcaccgc tgtcagtcag cgcttttaaa aaatgccctg ccattccggt gcaagaggcc 2090041 cccagcgcaa ttgcctttgc cacgtcaagc gcatcttgca gaccgccaga ggcgatcatg 2090101 gtgcttgcag gaaactcaga gcggatttcc gccaaacttg cagctgtcga aatgccccac 2090161 gaattaaaaa aggagatttg ccgctgtctt cggagatttt cgattttcga gaaatttgtt 2090221 cccccgtaac cgccaatgtc aacagctgca gcaccagctt catacagctt tcctgctgat 2090281 gctttgctca taccgaagcc gacttctttc acaatgaccg gtacactgac ccggctgcaa 2090341 atttgttcaa tgcgtttcaa tgcgccgcta aagcttctgt ccccttcagg catcacaatt 2090401 tcctgaatca cattgaggtg gatctgcagt gcgtttgctc caatcatctc aacggcttcc 2090461 tttgcctgag cagccgttgc ctcgcttccc aggttggcaa aaatcagccc gtttgggttt 2090521 tcctttcgaa caatttcata ggaaagacgc tctgatggat cttttaatgc tgacatttgc 2090581 gatcccacag caaggggaat tccagcctga gaagccgctc gcgcaagcga tttattaatc 2090641 tcatatgtaa gttttccgcc gccgccagtc attgcattga taaaaatcgg cgaactgctt 2090701 gaaagttcgc cgatttttgt ggaaatatct acttgttcta atgcaagatc gggcagactg 2090761 acgtgaacaa acgtaatatc atcaagacct gtttcccgct tctggccgat ggacaaggca 2090821 tgattgatgt gttgtctttt tcgttctgct cgagtcacgt ttatcaccaa ttattttagt 2090881 ttattcagct tatctccgat cagatctcca agctggaagc cagtgcttgt ttcttccttc 2090941 gcttgatatt gacggtaatc ttcctggtca gctttaggcg tttcttcaag ttcacgcatg 2091001 cttaatgaaa tgcgctcctc attttcattc acatcaagaa ccttcacttt tacagtctgt 2091061 ccttcttcaa ggacttcatg cggcgtgccg atgtgtttat tggaaatttg agaaatatga 2091121 acgagacctt caacacctgg aaggatttca acaaaggcac cgaagcttac aagacgctgt 2091181 acagttcctt caagcacatc gccaggcttc actttttcgc cgatttggtt ccaaggtcca 2091241 ggcagtgtat ctttgatcga taaagaaata cgttcattat cacggtcaac cgataacact 2091301 ttcactttta cttcttgtcc ctcttcaaca acgtcagacg gcttctctac atgagagtgg 2091361 gaaagctgtg aaatgtgtac aagtccgtcg atgccgccaa tatcaacaaa cgcgccaaag 2091421 tcagtcaggc gctgtacttt gccatcaagt acacttccaa cttcaagaga ctgaagaagt 2091481 tcttgttttt tattcgcttg ttcactttca acaacagcac ggtgtgaaag gatcacgcgg 2091541 tttttatcac ggtcaagctc tacaacgagc agtgacagtg tttttccttt atagtcagtg 2091601 aagtcttcaa cgaaatgtgc ttcaacaagt gatgccggaa taaaaccgcg aacgccgata 2091661 tcaacgacaa ggccgccttt cacgacatct ttcacttcag cttcaaacac ttcttttgtt 2091721 tcaaattttt tctcaaggtc ttcccaagcg cggtctgcat caacagcacg tttagataaa 2091781 atcaaagcat cgtcttccac ttttgttact ttcaggtcaa gctcgtcgtc tactttaaca 2091841 acatccgatg ctttctctac atgaagactt gataattcac tgattggaat aataccggat 2091901 tgtttgacat tgataatttc tacatctaca tgtttgtctt ctacctttgt cacaatccct 2091961 ttaactacat ctccaacctc tggcacttga acatcaattt gattcatttc ctctgtcatt 2092021 tgaataacct ccttggtcca aacctacaca gcttaattaa aacggtttga aagctgaaca 2092081 tataacatgc ccgcttttag ccgaatatgt attaaagaat catccaaaaa agttttttga 2092141 atgatcaata aaaagtttta ttagtattaa cttctaataa aaggacaggt ttgtcaagca 2092201 ataacattct atcttcgttg aaaaattcaa aaaaagtggc atttgccatc ctcagcggga 2092261 cttttgctcc acagcctcga ggattttatc agctacctct tgaatggaaa gcgatgtcgt 2092321 gtcgatttca agagcgtctt ctgctttacg cagcggagat acttcgcgct ctgaatcaag 2092381 cttgtctctt cttgcaattt cctcaattaa tgtttcgtag ttgacatcaa agcctttttt 2092441 cacattttct tcataacggc gtttcgctct ctcttccaca gatgccaaaa gaaagatttt 2092501 tacttctgca tttggcagca catgcgtccc gatgtcacga ccatccatga cgacgccgcc 2092561 tttttcccca agctgctgct ggcgtttcac catttcttct ctgacacttc tgtgcttggc 2092621 cgcaattgaa acttggttgc tgatttcatc tgttctgatc gcctcagtta catcggtgcc 2092681 gtttacaaac actttttgtc catcttttgt tgtaatcagc tcaatgtctg tccgctttag 2092741 cagctcagcc agtttttctt catctgtcag atcaacgttt tcctgtaaag ccgcgtacgt 2092801 aatcgcccga tacatcgctc ctgtatcaat atatatgtac gattttttct cagccacaat 2092861 tttggcaacg gtgcttttcc ccgcagctgc cgggccgtcg attgcaatcg ataatttctt 2092921 ttccataatt cctctccttg ctcttttctc ctctaaggat tgtatcacga actttatgaa 2092981 aaagggtgaa aaattgatga ataattaatg tttgaaggtt tcaatcctat tgttttcctc 2093041 cattttatcc accccttcat attgaatcac ttttgatacg tatggttcaa tatgctgata 2093101 gtgaaaaaga aattggacac caagtaaaat gatggcctga atgaacaata atttgatcag 2093161 cagccgttca aatgttttca ttggagcacc tccattacaa atagtatgga agtgtttgcc 2093221 gatgtttatt ccattcgggc ctttcttctc ttatttaact ggcgcctgat gcagtattga 2093281 agcaaagcct gctggtcacc tgctgcaatt tctgaatact ctaaagtcat ttttcgtttt 2093341 tctgacttgg ggtcattaaa gattcgtctg acaactgctt ctgtttctat ttgacgtgtg 2093401 tgctcctctt caggaagacg gatgatcagg cgcaatgatt cccccgattg aaaagaaagg 2093461 ccatcagcta aaaccacggc gatgccgcct gcactgatgt tataggatag tgtgcggatc 2093521 tcttcttcat ttcccggctg aatttgcaca tctaataccg catcagttct tacatattgg 2093581 cggcgctgga ttcttttcat tttttcacgg ggaggcattt caagacagat catttgaagt 2093641 ttgtccttca ctttaccttt tatacggctt ataaagcgat aaggaacttc gtcttttccc 2093701 acaaactcta ccgttacttc catatcgtta tgtaaaatca cagttcgccc tgtaactaca 2093761 tcaacaggat acgcgatcaa aagttcattg ttttcgatgc tgaccgcctt gctttttgcc 2093821 tttttcaatt cattttcttc tatatattct aaaagtacat tttctccaat ctctatcatt 2093881 gacttcactc tttcgcattc aatatactca cgtttttatt aaagcacgta atgaaaaaaa 2093941 ggaaaagaca tttagtcctt tcctcctgtt tttataggtc tttatatata ggttctgcat 2094001 tttttagttt ttcaaccttt tcttccgatc cgtctttggc attgatatac attctgaatg 2094061 tgtcattttc aattgtccca agcatttcgt agcataacac ttcttgacct agttcatttg 2094121 taatcaaagc gagccttgtt tctctcactt gtacattttt atttaattta gactttgcct 2094181 ctgcttcagt aattgcaggc ttaggtatgg ttctttttct gtgagatgtg aggaagtctc 2094241 ttgctgaaaa gccgacaacc tcaccgtcat ccaaggccac tttcatacga attgcctcgg 2094301 ggtacatccg gactttattt tcaacaggaa catatgaaaa tacaccgatt ttatcatatt 2094361 gggcactttc atcaatttcc aaatcatctg tttcaaatcc gtttttcttt aaaaatgcaa 2094421 gcgctcggtt cgatccgtca tttaaactga ttttctgatc tttcacttct ctgttttgga 2094481 tcaagtatac cggatgcccg cccttcttcg taatatccat ataaatcact gctttatggt 2094541 ctgggtcttt catgctgatg ctatatacat cgcgatttgt tttttttccg ctctttacca 2094601 ctttaattga ataattgtca tctggggcaa agcgctcagc aatttgtttt gcttcctgtt 2094661 cggaaatttg ttttcccttc agatggctga agcctttctc ttcttttttc gtactggtga 2094721 aactcgggcc aagatcagtg ccagtggaga atgcaccaac atttttttcg actgttttaa 2094781 agctgttgat aatcgtatta tcactttgtt tttcgtcaga agccagagcc atttctacgt 2094841 ccatccagcg aaggtttttg ctcatgacaa ggtgctgaac atgacgcaat tcattttgta 2094901 tatcttcgga ctgctgatat agcttattta gtgatgtata ctcgttttta tcaagcggct 2094961 tttggtccaa atctctgact gacgttttat agctgaaatc gccgatcttt gataatagct 2095021 cttcagtttt attaaacggc attaatgtaa gcggcagctg actgacgctg ttatgagctt 2095081 ctgatgtaat cctccacaca tcgatcaatg caggcgacag tgatttttgg ctgttcatgg 2095141 caagtgttgt tccgatttta tcatgaagct gatccacctg ataggtaagc tcatgaaacg 2095201 cccgctgata gttattttca gcatgaagaa gaactgcgtc tttttcctgg tgttctttgt 2095261 atccccagta gcctgtaccg actattgcaa taccaagcac ggcgattaaa attcctctga 2095321 tcatttatca cacctctttt tatgctttct catatctgct actcacagaa aatgtgttta 2095381 ccgattcttt taatctgcgg acgcccccaa atccacggac ttgtagccgt atccggatta 2095441 aagtagtaaa gtgcttcctc tgatgggtcc cagccattga tggcatccag cactgcttct 2095501 cgtgccgttt cattcggctg catgtaaatt tgtccgtcgg ctactgctgt gaaggcaagc 2095561 ggctcaaaaa taacccccgc tactgaattt ggaaataacg ggctgttcaa acggtttaaa 2095621 atgactgctg caatagcaac ctgcccctcg tacggctcgc cccgggcttc gccataaacc 2095681 gcttgagcaa gcagcctgat atcgttgttg gaaaatccac caggcatgtt cgctgctacc 2095741 gcatcctgtt ttcttgcttt tgctggtgta ttgttttgct gtttattcgc attcgcttta 2095801 ggcttctgcg ttgttttttc cgcaggctgt ttctgccgtg cttctgcttg ttgtcttgcc 2095861 ttttgtgttg ctgcttttga tggtttcgtc tgatacttta gcggaatttt tccgtaatgc 2095921 gtgaatgtat tccctttatt gagctgttcc atgacatatt cacgatagta ttttgattta 2095981 catattaagg tttgctttgt tttagctcct acaaggccgt caacctcttt taacccgaat 2096041 tgatcctgaa aatttcgaac tgcccagtac gtcccccatc cataaacccc gtcaattttt 2096101 ccgttataat atccgttgta ttgaagacgc gcctgaagct cgaccacatc atcccctgtt 2096161 gcccctcttt gaatgacctg attcgaaaag gcagagatcg tttcagtatt aataaacgtc 2096221 gttattgtaa aggaaaaaag gatgagacat gccataatcg atcctttgga cttcatcttt 2096281 tcaagcctcc tactgcaaat ttttaagtgt aatcgtattt tctgtaacga ggttattttt 2096341 atacactctt tccttgttat ccctcagaac ataaaaactg cacacaaaaa agccgcacgg 2096401 ttgctgtgcg gcttctatac ttgcatcata ttaacggaac gggctttttt cgctttacgc 2096461 aaaccaaacc accataaaaa taccataaat ggaagcatat aataaatcca attgctaagc 2096521 gctgttagga taaaatcata tgatccatgc aaaagggatg ggacaactaa agaaagagta 2096581 agccacttta cacgcgcctt atcagcggaa aaacgggctt ttccaaggta aaatcccatt 2096641 ataacgccaa tcaaggcatg gcatgaaaca ggcagcagcg ccctgacaaa cgcatgctcc 2096701 acgccgtggc caattaaata aagaatattt tcgagggttg caaaaccgag tgatacactt 2096761 gcaccgtaca caatcccgtc ataatgctca tcaaagtggg cgtgcgggta aacactgatc 2096821 atcagtataa accattttaa tgattcctcc aaaaaccccg aagataaaaa agaaacgaaa 2096881 aagcttccgc ctcctacatt ctctttttca agtacatact ggataaacat gatgggaaat 2096941 acaagaacaa ccccgagaaa aaacgaccgt agcaccatat gtacaggttc attatcatac 2097001 tgatctttta aataaaaata acttaataac gcgatgccgg gggcaattcc tgcagagatg 2097061 attgcaaaca tcaggcaacc tctttccttt atattcctac atctatccta ccatgttgtt 2097121 taaaatttta catctgtctg cacttaaaaa aacaaaaaga gcatacgaat gcatcatatg 2097181 ctcctcatct ttaatggttt tctcttttgg cgatttccgc tgcgatatgc cccccgtgaa 2097241 acctgccgtt ttcaataaat atttcatttg cattgtttcc cgcagcaata acaccggcaa 2097301 taaagacacc ttcaacgttc gtttccatcg tttcttcgtt gaaaaatgga cgccctgttt 2097361 ctttatcaat ttcaacacca attttttcaa gaaattgatg atcgggatga tagcctgtca 2097421 tggcaaatac aaaatcattt ttaatggtaa tgagttcttt ctctccggag cgaaacacaa 2097481 cttcattctc ggtgattttt tcgacacaag ctccaaattc catacggatt gtaccgtttc 2097541 tgacgagagc ttcaaattcc ggcagaatcc acggcttaat gctcggagaa tactcattgc 2097601 ccctatataa aactgtgaca cgcgccccag atttcacgag ttcaagggcg gcgtccacgc 2097661 ttgaattttt cccgccgatg acaacaacat ctttatcaaa atacgggtgg ccttctttaa 2097721 aataatgaaa tactttcggc aaatcctcac cgggtacgcc catatagttt ggatgatcat 2097781 aatagcctgt ggcgatgata caatatggcg tcgtgtaggt ctcttttgac gtctcaataa 2097841 cgaatgtgtt attttgcgtt ttcgtcactt tacgcaccat ttcaaacgca ttaacacgga 2097901 tgtttttccg tttaacgact tcccggtaat acgataaagc ctgaattctg acaggcttcc 2097961 tgttctctgt aataaatgcc acatctccga tttcgagctt ttcacttgaa ctgaaaaagg 2098021 tttgatgcgt cgggtaattg taaatactgt taacgacatt gcctttttcg atgacgaggg 2098081 catcaatgcc aatttgtttt aggtgaatgg cagcagatag tccacaaggt cctccgccta 2098141 taataattgc tttttcttga atcatttctg tcaactcctg cgattggcat ttcacttcat 2098201 attttctatt tccgaataaa aaaatctcct attttatcat aggagatttt ttatttttat 2098261 gcaaatcatc aacttatatc cagcctctaa aacgcgaagc ttcagccatt ttgcgaacgc 2098321 cgaccatata tgcagcgagc ctcatgtcaa ttcttcggtt gttagccatt tcgtaaatat 2098381 tgttaaatga tttgaccatc attttttcta atttttcttc tacctcttct tcactccagt 2098441 agaagccttg gttattctga acccattcaa aataagaaac tgttacgcca ccggcacttg 2098501 ccagcacgtc tggtacaagc agaatgtccc ggtctgaaag aatttttgtt ccttcaagcg 2098561 ttgttggtcc gttcgctgct tcaacgacaa ttttagcccg gatattatgg gcattttctt 2098621 ctgtaatttg attttcaatc gcagcaggaa cgagaatatc acaatccagc tccagcagct 2098681 cttggttggt aatggtatcg ttgaaaagct ttgttacggt accgaagctg tcgcgtcggt 2098741 cgagtaaata atcgatatca aggccttccg gatcataaag tccgccatac gcatctgaga 2098801 tgccgacaac ttttgccccc gcatcatgca taaattttgc caaatagctt cccgcgtttc 2098861 cgaagccttg gacaacgaca cgcgcacctt taatatcgat gcctctcttc ttagccgctt 2098921 ctttaataca gatggtaaca ccttttgctg tcgcagattc tctcccgtga gatccgccaa 2098981 gcacaagcgg tttgcctgta ataaatccag gcgaattaaa ttcatcaatt cttgaatact 2099041 catccatcat ccaagccatg atttgtgagt ttgtaaatac atccggtgcc ggcacgtctt 2099101 ttgtcgggcc gacaatttgg ctgatcgctc tgacataccc tctgctcaga cgctccagct 2099161 ctctaaacga catatccctt ggatcacaaa caattccgcc tttaccaccg ccatatggaa 2099221 gatcaattat gccgcatttt aaactcatcc aaattgaaag cgccttcacc gccttcacct 2099281 ctttttctgt tacgttcggg tgaaaacgta tcccgccttt cgttggaccg acagagtcat 2099341 tgtgctgcgc acgatatcct gtgaaaatct ttactgaacc gtcgtccata cgaacaggta 2099401 tttttaccgt taataatctc atcggctctt ttaacaattc gtatacctct tcgggatatc 2099461 ccaatttttc cagagcctta tgtattacgg tttgggttga ttttaataca tcaagtttgt 2099521 cctcttctgt atgaccggtg tttcgatcgg ctgccatttg agttaacctc ctagaatctt 2099581 ctgtttctca catgctccct ttcagagaat agtatacacc ttcatatgat ctgtgcatag 2099641 aataaacgtt atgtttttcc atgtttttta acgaaaaaaa actgctgaaa tcagcagttt 2099701 tccgttgcat tcttatgaaa aatgagtttg tatcgtttct acggcattac cgtccataat 2099761 gagcttacca tactcttgca ggcgataaat cgttaaagtt gtcggattgc cgtattcagc 2099821 cagaaccgcc acaacccctt cagccgtatg tgaccctaga tcttcaaggc ttaaaaagta 2099881 ctgcccgtca tagtggtaga cagttccccc tgtgataccg attcgctgta agctttctga 2099941 aagctgaatg atatcttcaa aggaatggaa ttgatatatg atgtccgcgc tttcatcaag 2100001 cttgacttgc atttcgatgt aatcatcatc atactcatcg tcttctgaat cggcgtcttg 2100061 gttctttgtt acaatcacga ccatcccttg tgcttggaga gaatacactt ccactgcaat 2100121 cggtccattc gcttcaaagc cgagctctgt atttgcttca ttcatcatat ctttaaataa 2100181 ctggtggact ttaaatgagt ccttccagag gtcttctttt gtcaatcccc ggtctgtcaa 2100241 atcatcgagg gttaaaaaga ttttgatctt attataattc agacgctcaa gccgcataac 2100301 gttccctcct gcctctactt gcacacaaat catataacac attatatgag atgatgagtc 2100361 ataggttctt aattgttatc agtttacact gagttcacta gtaagacaag cacaatgcag 2100421 tttttattgc catacggatt tttgcttttt agaagttatt ctggcccgca aagagtcaca 2100481 atgtgagttt caggctcagc acctaaacga agaggcactt ttgtcgtgcc gtagccgttg 2100541 ctgatcagat atgccgcgtt tttaacaata cctgttttcc ccagttcata aggaccgaat 2100601 tttccaaacc tgatctggcc tccatgggta tgtccgctga gtatcacatc aataccgtca 2100661 tcttcattga tttgttcatg aatctccgga ttatggcaaa ccagaatatt cagctggctt 2100721 tcatcaagtt ctttgatggc ttcctcataa tgatccatct ccatcctgat atcatcaacc 2100781 cccgcaatcg caatcgtatg cccattgtat gaaaacggga ctgactcatt tctcagagtg 2100841 atgacgccgt gcgctttaaa tatggaatac agcttatgct gcctgacttc ataatcatta 2100901 ttcccccaca caaacacgat agggaccccg aaatgtacga gccttttgat gttttcctcg 2100961 attctcgcac tgggcacccc gccctcagct aaatcaccgc cgattataac caagtggggg 2101021 gcatggcttc gcgctttttc taaaaggtct tgatcgatga gacgtttgtg aatgtctgaa 2101081 ataaaaaaga ttgtcagagg cggcttgccc ttcatctttg ataaaggaaa cgtatgtgtc 2101141 ttcaaatgat tgccttttgc tgttgcatac atttttgccg tcattgccgc tgccgcaaca 2101201 gttagtacac cggcaatttt cactgatagc ttcataaaaa actctccatt ctttttagaa 2101261 cttatcaata agacggacaa taaaaaaaga cgtttctatc gtttgagaaa acgccccatt 2101321 ttatttactt tcaaaatata gattaatgtc atatttgtgc ttcatcatat gaaaaacaga 2101381 ctctctcgcc ttccatttat cgggctgcgg ccagagatca gtgcttttct gaataatttc 2101441 acatctcagt ttatggaaat cagtctcgga tttttcttcc tttttcttga aataatatga 2101501 agtgcagtag gcaaaagcgg ttgccagcat ccaaaataaa taaaaggtat ggctaagtat 2101561 ttcttgaagt ataagctgag gctccgggct tttgatcatg atcataacac ataataagcc 2101621 taggcagata agtgaagccc atcgccatct gcggcattgt gctgcataat tttcgaattt 2101681 ttgttttcgt tttaccagcg cttggagcat ctgtttggtc ggcgcgtctg taaactgatc 2101741 cagctgattc cataaggatt ccatacgctt cacaccttgt ccattttcat tgctacaata 2101801 tatgaacgta aaataaaaat aataccctat tcatccatta aagggatgtc caaaacttgt 2101861 ccggtgtaaa catcatttcc attcagatga ttatatgctc gaattttttc ttctcctgtc 2101921 cggcttttat aatacttcat ggaaatgcgg tatagcgttt ctttcttttg gacggtgtgc 2101981 ttgacaacgc gattcggcac attttgaact ggctcagctg gctgttcttg ctgttgtact 2102041 gttgattggg aagaggaagc agccgcggcg gttgcttcct ccttatttgg cgagtcttct 2102101 ttttccgcta cagcagtctg tttcttatca gcagctgttt gctcttttgg cttggaatct 2102161 tctggctctt tttttgactc cttctgcagt gcggtttctt tagtgtctgc ggtatcgttt 2102221 ttatcctctg atttcgggac aacctcatat ttgctttggc tgctgtcaat aaaaacatct 2102281 tcataatcgt catgattatc cgggtggctc tttagataaa ataaggtgac taaaacgata 2102341 accggcacaa atacaaatat tactgcgagt actgtgaata atggcgtttt tgttttgcct 2102401 tgcttttttt tctgttctct ttgatttttt acagattgtc ttgtcggaag gctttctcca 2102461 tcatcgacat aatcgtccgc caatgcggcg ttttgatctt cataaagatt ctgggctttt 2102521 cttctctcta ctctcgacat gttcgtcatg tttatccctc ctcacatgtt caaaacgaat 2102581 ctgacaggca aacacggcat caatgataaa atgcgccgtc atcggaacaa ataagttgcc 2102641 ggtccattca tacatcagac cgagcaaaaa gctgattgct gtcaccataa taaataacag 2102701 ccattttgac aaataccgaa agtgcagagc ggcaaatata aggctggccg tccataaacc 2102761 gatatgagtc tgcagcactc ctctgaataa catttcttcc gcgaaagcaa tcagaagcgt 2102821 taaaaatata atatgaggga ttgacctctt actgaatatt tttttattga ttccgccgtc 2102881 atcatataaa tgagacggaa accatttcat tactgccata tcggctaaaa taacaataac 2102941 agctatagaa acaccatacc agatgattcg catatcgcga atgtcccaga gctttaatac 2103001 gtcccgtaca tcctcaaaaa agaacagtcc tgctgcagca gcggcaaaga tgatgagtag 2103061 ctgcgtcaaa tataactgct tcagcatatc atggtcagtc atatgctgaa tataatcttt 2103121 ttgctgtttc agttcagctc acctacagtc tgcaagctga atatccggtg caattccgaa 2103181 ctccagctgt ctaatggcgc cattttactc cgttcccctt tttgttcata caaggataaa 2103241 tcaaaaccgc aatgtgaaca gcacgggagg tttccgtcat caggctcgta tgattcatca 2103301 aagtaggtta acagtgcctg ccttaaacag ccgtcacgct gaagcaaaaa tgatacacgg 2103361 tgcatttttt ccagcttcag ctccatgcga tatgaaattt ctttcttcat cagttcaact 2103421 gatgtttttc cctgcataaa gagatgaatc atcatacggg cctgtgtctc tccgacgcca 2103481 tactgaagta atacgtcacg cagccttctc tcatcccgct cctccgtctt ctctagcaca 2103541 cggattacgt cggcgatttc ttcagctgtg acactctcca tctggataat ttgttcctgc 2103601 aattcaaaat cccctggcgc ccgcagcaaa atgctgacac tcggctttcc gtcgcgtccc 2103661 gctctgccga tttcctgcat aaaagcttct gccgtctgcg ggagatgaaa atgaatcaca 2103721 tatctgatat caggtttatc gacacccatt ccaaacgcat tcgtacaaca tatcacatca 2103781 agctggttat gaataaactg ctgctgaatt aaaatcctgt cccctgactc caaaccgcca 2103841 tggtaaaagt cggctctgct gctcgttttg cttttaattt cacccgctaa ttccttagcc 2103901 catttccgtg ttggacaata aacaattccc ggaccttgca ggttttcaac cagctgaatg 2103961 accctatcta ttttttcggc agtatccgcc gcattttcaa ccctcagtgc gatgtttggg 2104021 cggttgactg agttgagatg gcgtacagca tgctgcagct ccagcaggtt catgacatct 2104081 tgcagcgttt cctttgtagc cgtggcggtc aatgccagaa cgggtgggtg tccaagtttt 2104141 tttctcagct gtccgagctt tgaataatca ggcctgaagt cgtgtcccca ttcagaaata 2104201 caatgcgctt cgtcaataac aaataggcta atcggaacgc ttttcaattt ttccaataca 2104261 tatggagact gtaaagcttc aggagacaag tacaaaaatt tatatcgatg aatatgttct 2104321 aaaacaaatt gtctttcctg cctgttaagc atgctgttca aagctgcagc acgcttttcc 2104381 ccccgggctt tgagctgctg cacctgatcc tccattaaag aaagcagtgg agaaacgatt 2104441 aataccatgc catcaagcat ataaccaggc agctggtagc aaagcgattt ccctccccca 2104501 gtcgggagca ttgcaatggt atccttcccg ctgagtatgc tttcaataat gtcctgctgc 2104561 ccttttttaa aggaagtaaa accaaaaaac tgatataacg tttgctgtaa tttagtcata 2104621 ttgctgcacc tgctttgtca atgccagtct gatttgaaag tagctgaacc gctgttccag 2104681 cccgtcgcga atttgtttga ttttattcgt ccgcatccgt ttggcaaact ctgcgatttg 2104741 aagctggtct tctgctgata catagtcatt aatcataaac gcaggctcat ggagagaaat 2104801 ctcgacaatg tggtcttcaa tcgtcgctgt tttcagcttt ctgatttcag caattcgctg 2104861 tatcggaaac ccttgtttga ccatctgcca tgttttcctc gtcgactctg tcagggcatt 2104921 atctaagtgc acatcagaaa ggagatcctt taacaaagca tcttcacact ccggaagaga 2104981 atgaataaaa taatgtaccg aagcccaaaa catgatatag acataccatt cgtcttcttt 2105041 cagcgtatca gcaagctgcc tgctcgtata accgatccga tggtgcgagg ttaaggagta 2105101 gacaaaaatt tgcgctgctt tgttttcaat ctttttcaaa tgcgcctcaa gcatggcaaa 2105161 aaggcttttt gccatctcta tatgatccgt atgccgggac aggtatttct ttacccagtg 2105221 aagtgtctta tgatcctttg tgacagggat atactgcctg ctcccttgct gtttatggga 2105281 taggacctgc acaagcagcg aaagcctttt ccaaagcacg ccggcagcct gctgataatg 2105341 agcgccgtga caatgaacgg gccaaggccg ctcgctaagg gcatgtctca aaactgctgc 2105401 gccgctggct gtcactttgt atgtatctga ttcagacatt ggcgcgagat atgaatgctt 2105461 ttcaagcttg tcaagcgacg cagaaatatc gcttctcgaa cattttgccg ccattccaaa 2105521 gtattttgca gtctgaaata agccggcatc ttgaatggtc tgtgacgatc tcttgccttt 2105581 gaataggtga aaaacagcgc ttcccgaccg ttccccgttt attttgcaaa gacaatcgag 2105641 aaccataata tcgaagtaat ttaatgacaa cctatccacc tacattcttc ctgacaaaaa 2105701 tcgttgattt gctcttttta ttttaacaga tttcaaacag aaatcgacgt ttaaagtcat 2105761 cattaagggg gatgttatgt agataacccc ttatgtgata agcattctca atcatttttc 2105821 tgttgaaatg tggcagcaac atcattacaa taagtaagag gaataggtgt taaattgatt 2105881 aaatataaag attgatccat ttgttccacc aagaacaatc tgggaggttt tattcatggc 2105941 aaagtacaca atcgtagaca aagatacatg tattgcatgc ggcgcttgcg gagctgctgc 2106001 accagacatt tacgattacg atgatgaagg catcgcgttc gtaacgcttg atgaaaacaa 2106061 aggtgttgtc gaagttcctg aggtactgga agaagatatg attgacgcat ttgaaggatg 2106121 ccctactgat tccatcaaag tggcggatga gccatttgaa ggcgacccgc ttaaatttga 2106181 atagaagtaa ctaaaaaaag ctcccgaacg ggagcttttt tatttaatgg atatgtgcac 2106241 ttcgctgctg ctcaatccat ggcttaagct tgataaaaat tagtgagaat acaaccgtaa 2106301 ttacaatacc ttttatcatg ttaaacggca ggatacctgc gacgactgct gtttttagcg 2106361 cgctgtcgga taatgccggt gaatgtaaaa accacgtgta tgccggaaga atcagaacat 2106421 aatttaaaat actcattaaa atggtcatcg ctgcagttcc caaaagcagg ctgacagcca 2106481 agccctttgc tgagttgagt tttttaaata agaaagcagt cggtaatata aagagtgttc 2106541 ctgcaataaa attcgcaact tgccctacag gaactccggc catgcttccc tgaatgatat 2106601 actgaagaac attttttatc gcttctacgg caatacccgc caaaggtccg taaatcagaa 2106661 tggcaataat tgcgggaacg tcgctaaaat cgatttttaa ataatccgga agacccggaa 2106721 acgggaaatt taacagcatc aaaacaaatg caatgctgct cagcatgctg accacaacta 2106781 atttttttac tttcacttca ttctctcctt ttcgatcaca tcttactcga aaacggaaag 2106841 gttcttttcc agccaataaa aaaaccgctt catatataaa agcggggttt cgaaaattag 2106901 gctaggcaaa gaaacgtttg aaaaattcaa tttcaaaacg cttatgaacc tccatcttct 2106961 cccatccaga ctgtactgtc ggctccggaa tctcaccgaa tcctgctgta aagacagctc 2107021 gcgggcttag agccattggc tcatcaccgc cggtagggaa tttcaccctg ccccgaagat 2107081 tgatcatatg aaatttaatt acattataaa cgataactgg ttggctgtat agagaattgc 2107141 ttcaaattaa atatattacc tgcaagctgt cagatcattg atttattagg ctttactttt 2107201 atcctttact gcgtcaatac acgttgacac tcttttgaga atatgttaaa ttatcagata 2107261 tttagtttgt caatttagga ggaaatctaa cgatgtttcg agtattggtc tcagacaaaa 2107321 tgagcaacga cggtttacag ccacttattg aatcagactt tattgaaatc gttcaaaaaa 2107381 acgtagcaga tgcagaagat gaattacata cttttgatgc tcttttggtg cgaagcgcga 2107441 caaaagtaac agaagacctt ttcaacaaaa tgacttcttt aaaaattgtc ggaagagccg 2107501 gtgtcggtgt cgataatatc gatattgatg aggctacgaa acacggggta atcgtgatca 2107561 atgctccgaa cggcaacacc atttcgacag ctgagcatac atttgcaatg atctcttctt 2107621 taatgagaca cattccgcag gctaatatct cagtgaaatc cagagagtgg aaccgcacag 2107681 cttatgtcgg ttcagagctt tatggaaaaa cgcttggtat tgtaggatta ggccgaatcg 2107741 gaagtgaaat tgcacagcgt gcgagagcgt tcggtatgac tgtgcacgtt tttgatcctt 2107801 tcttaacgga agaaagagcg aaaaaaatcg gcgtaaacag ccgtacattt gaagaagtgc 2107861 ttgaaagtgc ggatatcatt accgttcaca cgcctttaac aaaagaaaca aaaggcttat 2107921 tgaataaaga aacgattgca aaaacgaaaa aaggcgttcg cttaattaac tgtgcgcgag 2107981 gcggaattat cgatgaagca gcacttctcg aagctttgga aaacgggcat gttgcgggag 2108041 cagcgcttga cgttttcgaa gtcgaaccgc cagttgacaa caaacttgtt gatcatccat 2108101 tagtcattgc cactcctcac ttgggagcat caacgaaaga agcacagctc aatgtcgccg 2108161 cccaagtgtc agaagaagtt ctgcagttcg caaaaggcct gcctgtcatg tcagctatca 2108221 acctgcctgc catgacaaaa gatgaatttg ctaaaattaa gccttaccat caaattgcag 2108281 gaaaaattgg cagccttgta tcacagtgca tgaaagaacc agtacaggat gttgccattc 2108341 aatatgaagg cacaattgct aaacttgaaa catcgttcat tacaaaagcc cttctgtcag 2108401 gctttttaaa accgcgcgta gactctactg ttaatgaggt caatgccggg ggtgtcgcaa 2108461 aagaacgcgg cattagcttc agtgaaaaaa tttcctcttc tgaatctgga tacgataact 2108521 gcatcagcgt aaaagtgaca ggagaccgca gcacctttac tgtaacggct acgtatattc 2108581 ctcatttcgg agaacgaatt gtcgagatca atggatttaa tattgatttt tatccgactg 2108641 gtcacttggt gtatatccag catcaagata caacaggtgt catcggccga gtaggacgta 2108701 ttctcggaga taatgatatt aacattgcaa ctatgcaggt tggccgtaag gaaaaaggcg 2108761 gagaagccat catgatgctt tcctttgaca gacatctgga agataaaatt gtgaaagaac 2108821 taacaaatgt ccctgatatt gtgtctgtga agctcattga tctgccataa ttaaaaaaac 2108881 tcaagctata tagcttgagt ttttttattg ttctatcccc gtgtgttttt atgcaaaata 2108941 tctaagacac tccttagctc agaaacagga atttggcctg gtgcggacgc ctcttctcca 2109001 gctccaaaag tacaagccga tccaaaaacc tcaccgctca gcctgctgat gagccctgtt 2109061 gcagccattg acattgtaat aatggggcgg tctgcatata ttgttttcat tgtatacgtc 2109121 gcatcaagca gtgttaggag atctccagta tcattcggca tgacagccat ttttggaata 2109181 tgcgcgccta agtcctgcat ttttcgaagt ctggaaataa tttcatcttt tacaggtgtt 2109241 ttttcaaagt cgtgatttga catcaccaca tagacgttgt tttcttccgc cagcgatact 2109301 aacgctttta catttgcatc tcctgaaaat aattcgatgt ctatcagatc gatgtctttt 2109361 gtttggattg ccgattccag caaagcaaga taggagcttt cgtccatctc catgctcccg 2109421 ccctctttgt gggttctgaa tgtaaataga aatagcttgt cttctaaaga tttacgaagc 2109481 ttagaaatga gctttgtgac cgcttctctg tcattcgctt tttcaaatac gtcgactctc 2109541 cattcaacaa tgtccggatt cagtaatttt actgcctctg cttcattcag aatttgtttt 2109601 tccgtctttc ccatcagcgg aatgatgatt ttcggcatcc cttccccgat ggaaactcct 2109661 ttaatcgtta acacgttcac tcgtctcaaa tcctttcaat ctttaccttg ttttattata 2109721 cacgtacaac ttttttttga aaatttctat tatatgaata gcaactaaaa aagagcctta 2109781 aagggctctt tttagtttaa ggaaatcgga tttggagcag ctggcaccgg aattgcatct 2109841 gatatgtcat atttgccgat ttttttcgtt ctggtttccg taaaggtcac ttctgtgaag 2109901 ccaaactctt ttgcagtcaa aagtagtccc tcaatcatta aaataccggc aatagaatca 2109961 tcaacttctg actcctttga aaagcggata tataagtgtt tctgtttctt cgttacagat 2110021 tggacagcac ccgcttgaat aagaggtgtc gtatcttctt ggctgctcga ttccatttcc 2110081 ttaatcgctt cttttactgt atcaaaagaa tgatttgacg gaacgagaaa gtcttgtcct 2110141 tgtttatttt ggtacaagta gtaggatcgt tttgactgtt tgggaatcga aatttccgta 2110201 aaagtgccat atgagccaat ccgaacccca gtctcatttt gatccgataa aaatttgact 2110261 ttttcataag gactccattt taaggattct ttaagcaatt tttttaacag tgtatcatct 2110321 tttatagaaa atgccgtagc tggctgatgg actcgtatac ttaattcctt ctgctttggt 2110381 ttttccttta tttctacttc atctatgaag gttggaattg taatggcatg atcaaggatg 2110441 cccaattcac tactttcaaa cagcatatcc tggatcgttt ggtctgcatt tgttttttga 2110501 atgctgacgg gtatgattgc agatgtatcg gcatcagcaa ccgctacagt gatgtaattg 2110561 tcttgttcct tttcaggaac gacaaacgat gtctgatcca aggacgatgc agcttttggg 2110621 ctgtcttctg tctcagtttt cgttactgcg ttctcttggg acgcttcttt ttgttgaggc 2110681 tgtgcctgat caaagaaatg aggagaaata atgaaggcga tataaaccgc aattgcagcg 2110741 gcacacgcgg ggccaatcca cctgacagcg ggcttatttt tacgctttgc catcgtcagc 2110801 cgcttgtaaa tatcctgagg cgaacgatgg tctttaactg ccggaagttg acttaacaac 2110861 tcctttatct gttcttcgtt ccattctgac ttcatcatcc attagctcct ccctcaaaag 2110921 ctccatatgt ttccgaagta ctttgagccc tctgtgttgg gtcgttttta ctttgctttc 2110981 cgagaagcgc agagccttgg ctgtttcctg tattgaatat ccctgaataa accgcaagat 2111041 aatcacagct ctttgatcga ttgtacattg atcaagcgca gcataaattt cccggacatt 2111101 ttcatgttga accgcaagtt cgtccggcag caattgctga tccctgacat cctgtgtatc 2111161 ccagtcaaat gtaccgagta tacgctgtct gattgtttgc tgtttacgga accagtctat 2111221 cgcaacatgg cgtgcgatag acaaaagcca tgttttttca ctgcttcttc cttcaaacgt 2111281 atgataagaa tttaataccc ggatataaac ctcttgaaga aggtcttctg tctggttttt 2111341 atcctttacc atataaaata aaaattggta caaatcttga tgatatgtat catataataa 2111401 ttgaaaggtt tcttccattt gaaacccctc cgttcacttt tttgtcgtat gaatagcttg 2111461 aaaagttaca ttacaactat attacgagta actggaattt ggaagggaat ttatattaac 2111521 atatccttaa attttattaa tgttggctat taaaaaaaca cccgctcagt cagcgggtgt 2111581 ttcttatgga acaagattct tcggcaaatt cagactcgat tttaccgttt tgtcggaata 2111641 taaaaagaaa atgttgttcc tttatctatt cggctgtgca cagtaattga tccgttgtgg 2111701 gcttccacga tatttttaac gatagccagc cctaacccgg ttcctgctct gccccttgtc 2111761 cgcgctttat ctgccttata aaaccgctca aagataaatg gcagatcttc ttccggtatg 2111821 ccagacccgg agtctttgat atcaattttc aatccatcct tcacagaatg gactgaaatg 2111881 gagacactgc cgccggctga agtatgccgc agcgcgttat caatcaaatt ggtaaatacc 2111941 tgctccatct tgtcttcatc aaacataaat tcctcttctg tgagagaaat gtcatgatct 2112001 aaagcaatat ttttttcttt cgcaacaccg gaaaacttcc gaatgatctt ttctaaaaac 2112061 tcattcacat tgattttttc ataatgtaag cctgtatggc ctgattccat tcgggctaaa 2112121 tcaagcaaat cattaactaa acggcccatt cggagcgatt cgtcataaat gatttgggca 2112181 atttctttcc ggtcttcttc agagcttgca atgtcatcga caattgcttc actgtatccc 2112241 tgaagcatgg agatcggtgt tctcagctca tgactgacat ttgcgataaa gtcctcccgc 2112301 agcttatcaa ggcggcgttc ttctgtcatg tcacgcagta cggcaaccgc tcctctgacg 2112361 tgcgattccg cataaagcgg cgacatcaaa agcacccatg atctgccttg aagcgtcatc 2112421 tcaatcattt gttctttttc agtgctgaca gcgttttgaa acagctcttt tgcttcaggc 2112481 ggaagattgt cgccttcttt gatattcatg ttctgttcat aataccaagc ctgaagaaaa 2112541 cgttcagccg gcgggttggt cacaagaatc gtaccgtcaa tattaatggt aataaccccg 2112601 tcagccatac tgctcaaaat gttagaaagc tgctcttttt cttgattgag cgcattgata 2112661 tgaaagttaa gctgccggcc catttgatta aaagcggtcg ccagttcacc gatttcatcc 2112721 tgagttaaaa tcgggatttt tgtatcgaac ttgcccttcg ccaaatcctg cgcgccttct 2112781 ctcatttttc ggagagggta cgtgaccctg cttgataaaa agaatgcgaa aaatgtggtc 2112841 agcacaatcg caattccagc ggcaagaaaa atatagcggg tcgtatgttt tgttgtatct 2112901 ttaacggcaa gcaaagactg ggataaaaag accatgcctt tctttccgtc tttttcatac 2112961 gggacaccta caatcaggcg ttcattatcc gtgtctgtat cgctcagtcc cgtccgtttg 2113021 cttacttttt tatggtcttt gagagcttta tttaagtctt tgtcatgctg tatttgctca 2113081 accgtaatag acgacaggcg atttttatca ttcggagaat accagtggtt cttctcatcc 2113141 tggatgatgg caatgcttgt taagttatca gcgagttccc aagtgattga ccttgccagt 2113201 gcctggtcct cgtgattttc taggatgaca gcaactttat tcgcaagctg tgttaaatca 2113261 ttctcagctt cttccacatg gtagttttca ataaactcca gcaaaagaac cgttaaaatg 2113321 aacaatacga tcaagacgag tgaaaggatc gtaaaccaca gcttgcctac tacgcttttc 2113381 caaaatttca ttcagcgccg acctcaaatt tataacctac accccatacg gtgacaattt 2113441 ttttcgcagc ttccggagat accttgttca gcttctctct caagcgtttg acgtgagtgt 2113501 ccactgtccg taaatcacca aaaaactcat attgccacac ttctttcaga agcttttccc 2113561 gatcatacac cttgtcaggc gttttcgcta agaaatatag aagctcatac tcttttggcg 2113621 tcaggctcac ttctgttcca tcagctgtta cgcggtgagc atcatggtct attgacagat 2113681 gtgaaaacac gagcacattt ttcgtcggtg tattggcatt gaaataagag gtttgggatg 2113741 ctcttctcaa aagggccttt acacgcagca cgacttctct cgggctgaac ggcttaacaa 2113801 tataatcatc tgttcccgct tcaaacccct gcacccggtt tgcttcttct ccttttgcgg 2113861 tcagcataat aatgggtgtc gctttttttt cacgaatttg ccggcacact tcaattccat 2113921 cagtccccgg catcatcaga tcaagcaaaa ttaagtcata attggcttca agccctttgg 2113981 caatggcttc atcaccattt tcagcttcat ctatagcata attttcacgt tcaagataca 2114041 ttcttaaaag gcggcgaatt ctggcttcgt catcaactac taatattttt gtttcgttcg 2114101 tttggtccat gttttccccc tgctttcctt ctgttacttt cattttatca aatcgtgaga 2114161 aagtttgaga actgtgtcgc tttcaaagga ctatgcataa gaatgaagtc cggcaagcac 2114221 aagatttacg aatattaaat taaacataat aatagcaaaa ccgattacgg ccagccatgc 2114281 tgacttctca ccgtgccagc ctcttgacag tcttaaatgc aagtaagcgg catagaacaa 2114341 aaatgtgatc agcgcccata cttccttagg gtcccagccc caaaatctgg tccacgcgag 2114401 ctgagcccaa atcattgcaa agatcagcgc gccgagtgta aagatcggaa atccgattga 2114461 tacggccctg tacccaacct catccaccag atcaagattg acgtttttca ccagcggatg 2114521 taatagagcg ctgattcttt ttctgatgat cagacggaga gccccataca acacaagacc 2114581 tgctccaaat gaccaaatga cagtgttcac ttttctgcct gagaaaagcg cgggaagatc 2114641 aacaagcggt tccattcttc cttcggtcaa aagctctccc tgatgcggac cgacaagcgc 2114701 gggcatttcg tacaccatca cgcttttttc tttacttttg tccacccagt taaactccgc 2114761 ttcatagcct gcaagacgaa atgccgatgt gattgcaata aaggcgacgg ttgtgaccag 2114821 gataaacata atcgcttcaa gccagaaggt ctttttgctt ggctttgtct ggtctacatg 2114881 cttcaaaaga aagatgacac cagcgacaaa gctgatggca agtatagctt gcccaagcgc 2114941 ggccgttgtt acgtgaatat acagccagtt actttggagc gaaggaatta aaggcgagat 2115001 atctgtcgga aacatgctgg cgtaggcaat cagcaataaa gcaattgaca gcgtaaacag 2115061 gcctaatgaa ggcaatctat agagaaaata aagaatgata aacgccaaaa caagcatcat 2115121 gccaaaagcg gtggtgaatt caaacatatt gctgacaggc gcatggccgc ttgcagccca 2115181 ccttgtgatg aaatatccta ggtggcagaa aaaaccgaca atagaaaggg tgattccaat 2115241 gttggcccat cggtttggcc tgcccttttt atctttattc ccgcgtatgg ccccgccgaa 2115301 gattgggaca gcgattaaat acacaagaaa ggccgcataa agaaaatttc cgctcagctc 2115361 tgccatgaca tcactccctt ttcgcctatt tctgtgtttt gattaattct ttttggtcca 2115421 ccggttcagt cagtccggaa tcagccaata taaatgctaa atccttcttc aggccaaacc 2115481 agtttttatt ggtatgccct gctaccataa ctgcaccgtc ctgtgagtgc agccaaattc 2115541 ttcgatgctg ccagtacata ccttgaatga caccgatcat aaaaatggct ccgccgacag 2115601 caagcaccca gagtgtcaga tcctttctga ctgtaagtcc agtaatgttt ttcgtttcga 2115661 catggtcaaa tttcagcttg tatttattat tgcctgatcc ttcgatggtt tcttggatgg 2115721 cgacaaagct cttttcgcct ttcggtttgt ccggcgttat gatattaaag acaaaagccg 2115781 gattgttagg gatctttgtt tttgtgctcg gctctccgtc ctgattaaaa tagaagtcag 2115841 gcaggtagct ggcgatttcc accttgtaac cgttaccaag atcatagact gaatctggat 2115901 ccagaaggtt gatcttcagg ctcccaaagg atttttttgt ttttttatca atcagctgga 2115961 acaccatttg gtcaagctga ttctctttgt aatccacctg gtaaacggaa aaagaatcaa 2116021 aacgcagcgg ctgattgaca cggatgtctt cttctgttac tttttccagc ttcggcttct 2116081 cgccataaac aatttttcct tctctcttgt agagtacggc atcagtttga aagttctttg 2116141 ccactctacc gtccccgact ctgtcaatgg catctgcaaa tacctttttt tccgttttgc 2116201 tgttataggt ctctacgctg aattgattgt ttttcaaata atattttccg tctgtacccg 2116261 gaattgctgc ggtttcgcct tctctgaccc aaagcgtctc atcgacgtac atgccaggca 2116321 caaatctcag catcgcacca atcagaaaga tgatcaatcc aatgtggttg acatacgggc 2116381 cccagcggga aaagcgtcct ttttcagcaa gaatgctgcc ctctttttct ctgattctat 2116441 aatgtttttt ctttaataga gtaactatct tttctttcga ttccccgttc agtacagtaa 2116501 ctgtttcact gaacaagcgc tgccttctta aaaaggccgg gctccttctg acaccttggt 2116561 tttttaacgc tctatacaac ggaatgaccc gatcaaggct gcaaatcacg agtgaaatgc 2116621 cgatcgaggc aatgagcagc aaataccacc aagaaccata taaatgatga aacccgagca 2116681 aataataaag ctggccaaac gtgccgtact gctccttgta ataagtatca gcctgtgcgc 2116741 ccggaggcag ataggcttcc tggggaaaaa tggtgccgaa cgctgatgcg gcaagggtta 2116801 tgacgataag ccatattccc accttaaccg aggaaaagaa attccaaatt ttgtcgatga 2116861 tcgttttgtt ataggtttgc gaacgtcttg cgcttccgtc atatctcata tcagcgagcg 2116921 gaggttgagt ttcctgaaga gctcttccgc acgattcgca taaaacggtt ccgaccgggt 2116981 ttatatgtcc gcattcacat ttgacttgct tcatcccgaa gtctctccgg gttttatgag 2117041 attcatataa tcgtgtatca tgctttctgt catagtgccg gtcaccacct tgacaacttt 2117101 tccttccgga ttgatcaaaa aggttgtcgg aagcggagat acgtcatagg catcaagcac 2117161 ttggcgatct gtatccagaa caaccgggaa attgactccg taggatttca taaaattatg 2117221 tactgctatc tttgactccc caacatttac agcgacaatt tcaacacctt ggcttttaaa 2117281 atgcttatat tggtttgcca tataaggaaa ctcttttttg cacggttcac accatgtacc 2117341 ccagaaattc aaaaaaacac ctttcccttt taagtcactg agctcgatac gtttcccatt 2117401 cgtatcctct aggacaaaat tcggtgcgtc ggacccttcg gatatactct ctttgccggc 2117461 aaatacagcg ttgtaaatgg tatagccgag tgcgcagatt aaaacgagaa ggatgccggt 2117521 ccgaatgaat aaacgccttt ttttcttcat tgtccactgc ccccttcccc ctattgcaga 2117581 tccattcaat tatatcattg cacgttcatt tcacatttct tactttttga aggttatgtg 2117641 aaatttagaa agcgttttta ccgtgatccg ccagtgctct gagccttttt acttcgtgag 2117701 gcgtaagctc tctggcatcg cccgtgtgca ggcctcgcag gtttaaaaac gcgtattcct 2117761 cacgcttcag cttgattacc tcatgtccga tcgcttcaaa catgcggcgc acttgtctgt 2117821 tgcgtccctc atggatcgtc agctgaataa tgcttgtctg ctttttctta tccaaagaca 2117881 gcagcttcgc tttagcaggc gctgttttgc cttcctccag cctaattccg cgctccagct 2117941 ttctgagcag ctctttaggc gggattcctt tcaccttcgc cacgtatgtt ttgtctattt 2118001 catacttagg atgcattagc ttattggcga attcgccgtc attggttaaa agcaaaagac 2118061 cgctcgtatc atagtccaga cgcccaatcg gataaatgcg ctgcggaata tttttaaaaa 2118121 agtccgtcac cactttgcgt cctttatcat cttgcgctgc ggaaataacg cctcttggtt 2118181 tatataagag aaagtaaacc ggctcttcgc gttcaacctt taacccgttt acctcaatct 2118241 gatcagaacc ggtgacctta acacctagct ctgttactac tttgccattc acctttactt 2118301 ttccttcttt aatcagctct tctgcctttc tgcgcgacgc aactccggca tgagcaatca 2118361 ctttttgcag tctttccatg tctttcacct caagtattat cttacttttt tcaaccttaa 2118421 caaacaagct ttttcaaatt cctatgccaa atctaaaaaa aacgccgttt tcaggcgctc 2118481 ccaaataata acgtaacgat gatgatagat gcaactacgc cgattaaatc tgcaagaagt 2118541 cccaccttta atgcatcacc cattttttta atgccgactg ctccgaaata cacagtcagt 2118601 acgtaaagcg ttgtatctgt agatccctgc atgacggaag ccagcctgcc gataaaggaa 2118661 tcgggcccgt atactgcaat taaatcggtc gtcattccaa gtgcggccgt accggagatc 2118721 gggcggatca gagcaagcgg cactacttca gcagggatgc cgatagcgga gaaagccggt 2118781 tttaaaagat ccattataaa atcaagcgcg cctgatgatc tgaaaacagt tatagcgaca 2118841 agcattccga ctaaataggg gataatggaa aaggcaattt ctatcccctc tttcccgcct 2118901 tcgacaaacg attcatatgt cggaaccttt ttgatcgttc cataaagaag aattccggca 2118961 ataatgattg gaatcatggc taaagacagc cagttgatga tttccatccg ctcaccttcc 2119021 cttctttttg cggcggtaat aaaaataccg atcaatgata atggcaccga ttccggaaat 2119081 aagcgttgcc aaaatgcttg gcccgacgat atctgtcggc gttttggagg aataagccat 2119141 tcggacagcg atcaccgttg tcgggatgag tgtgatgcag gacgtattaa cagctaaaaa 2119201 agtaatcatc gaccggcttg cttccgatcg gtttccgttc agctttttca tttgttccat 2119261 tgctttaatg ccaagcggag ttgctgcatt tccgaggccg aagaaattcg ccataagatt 2119321 agataaaata tagcccatcg ccgggtgatc cggcggtata tcagggaaca gtttagatat 2119381 aaaaggtctg cacatccggc tgaaaatatc caaaagccct gactgctcgg cgattttcat 2119441 taagccaagc cagaaaacaa gcacgctcat caatccaaat gagatcgtaa tcgcttcttt 2119501 cgcaccctta aacacggctt catttacatc ttgcagagtt ccgttgcaca tcgcaaaaac 2119561 gagtccgatc acggttaaac tgacccaaat tatattgacc attttgctcc gcctgccgca 2119621 ttcagaaaga ttgatttaaa cgtttcaaaa aattgtttct tcggtttttg atgccgctca 2119681 ttttcataat agatcggcac ttttgcgatg gttgcatcgt tgaacatgat ctccatgtgc 2119741 cctacgatgt cagggatttt cgaggcatct ttttcccatg cttttttcgg cttgagcagt 2119801 gtggtattaa tttttacatt ttctttttcc tcttcggtca gcaaataggt gatatcacgt 2119861 ttgataaaag ccttcgattc ataaaatgtg cctttcagct ttggaatatc cccttttttt 2119921 gcaattaaat aggtttgata atgctcaaac acatagttaa acatcttcat atggtcatcc 2119981 caatcattag ggtcattaat ggtgacggct atcaggtcaa tgccgtcctt tgaagccgta 2120041 gagaccagtg tccgttttgc aagttttgta tagcctgttt ttcctcctgt gctgtacgga 2120101 taaagcatgg tcagcagttt gtttttgttt ttccatacgc tttccatcgt ttccgctttg 2120161 tatatttttg tgcctgaaat cttttgatag tctttcagct tcatagcata cttagttaaa 2120221 atggccatgt cataggctgt tgaataatga ttttcatggt cgtccaatcc gtgcgggttt 2120281 tgaaaacggg tgtttttcat accaagctgc tcggcttttt gattcatcat ataaacaaac 2120341 ccatcgaggc tcccaccgac atgctcagca atcgcgacag cggcatcgtt tcctgatctt 2120401 agcatcaggc catacacaag atctttcagc ttcacttttt gaccttctgt taaataaatg 2120461 gcggagcctt ctgttctgac agcatttgcc gaaaccgtca ctgtttgatc cattttgccg 2120521 gattcgatgg cgaggacggc ggtcataatt tttgtgatgc tcgcgatccg ccttttttga 2120581 tgctcatcct tggcatataa cactctgcct gacgcaccgt caataatgat cgcgcttttt 2120641 gcactgacat ctatagcagc atgtgctgta ttcacattta cggttgcaat aagaaaagaa 2120701 atcatgatca cgaatactgc ttttttgaaa atgcgcatgt ttgctcacgt ccttgtggtg 2120761 gtttgtacaa gtttatgcgc atgtccatca gttatgaata acaattatat ttctggaagc 2120821 aaacataaaa aaactctccc tgaaaaaggg agagtaaacg ttatctgatt ggcgccatgc 2120881 ttgatccgga cgcttcgtaa tgagccagct cttccctcat cttcagaaag gccgcgctca 2120941 acggcaataa taattgctca agcgacgcag gaacagcatg ataaaactca attgcgctga 2121001 ccccggtata agacgcccgg ctattttcac accacgtgtc ttttttcggc ataaagaact 2121061 cttcaatgca ttggtgatac acattataaa gtgttttttc cgctctggct tcctgaaaag 2121121 gctcctgcat caggagacga cggcacgctt ctgcgcctcc ttcacaaaat actgccattc 2121181 ttctcagagt gctaagcaca tcacagcagt atcctttttc aataggcaat tcagcctgta 2121241 aggactcaag cgtcgtttga tttaggtaat cgttcacggt attgacaacc attgataaga 2121301 attcgcctgt tttttgagtc tgcgctcgca caatcgaatg tcccatttcg tttggtatct 2121361 tcccctcatg tatttgtctc tcacattttg cttctttcat gatagcttct tccttatatc 2121421 ttatgatgat gaaaaagcgc gattcattaa acttctattt tatatcttcg aaggtttggt 2121481 taaagttttc aaaaaataaa tctgcttctt cttgaagaac gtcttcttcc gcattttcag 2121541 gcagcggcgg aagctcgtcc agcgttttca gaccgaattg ttcaagaaaa gtcggcgtag 2121601 taccgtataa aatggcccgc cccggaccat cggcacgccc tacttcacac aatagcgcct 2121661 tcgcgacaag actgtgtaaa atccgctctg attttactcc tctgatttct tcaatttctg 2121721 ctctcgtaat tggctgtttg tatgaaacaa tggccagtac ttctaaagat gcttgagaaa 2121781 ggccctttga cggcacttca atcagttttt tcaagtaagg cgcaaagtct tttttggtag 2121841 agagcatgta cgtatctgca tactcaataa gttcaatccc tcgtgtatct ccgcggtatt 2121901 cgtccgccac atccgccatg atcgtgttca gttcaggctc ttcgatttca agcactgtta 2121961 acagctgctt ttttgtaagc ccttcatcgc ctgccgcata aagaagggct tccacaatag 2122021 ctttccaatt cacgatatca agccccatga atggattcac tccccgtaat gtaaatatct 2122081 gaaaaattgt gctcctgttc aatgaggacc agctgatttt tcatcagctc aagaacagct 2122141 agaaaggtca ctactaaatg ttctttttgc tcatatggaa acagatccat aaagttaatt 2122201 ctcgttcctc tagatttcaa gctgtgcacg atttcgttca ttctggcttc gattggtatg 2122261 tcctgtcttg taattgttgt ttccatcggc ctgtttattt ttttgcgttt cagcactttt 2122321 tgaaaagctc cgatcatatc atagaccgtg acagagagct tttgctcaga ctgttttact 2122381 tcttttgcat attcactcaa atcactcggc ggtttcgtga acgatttttg tctttcttct 2122441 tcccgttctt ttaaatcctt cgccgcatct ttatattttc ggtactcaat cagcttttca 2122501 atcagttcct cccgcggatc ttcttcttca agtaattcat cttcaaaaag ctcctcctct 2122561 tgcttcggga gcagcattct gcttttaatg ctgagcagcg tggcagccat aaccaaatac 2122621 tcgctggcaa tgtcgagctc aagcacgcgc atcgtatgta catataataa atattgttca 2122681 gtgatcttcg ccacaggtat atcatatatg tcaatttcaa gacgattgat taaatgaagc 2122741 agcaggtcca atgggccctc aaacgtatca attttcactt gatattcttc catcatctca 2122801 ccattttcaa gtatcactct cattgccgga aaaactggct accctatagt ataagccacc 2122861 aaaaagctct cgtccaatac tatttcatat cctgttttga aggagtttgt acagaatatt 2122921 caaaacacaa gaggtgtttg ctcggagcgc agaagcggga gaaaaagcct ttgcttctgg 2122981 ttttcctttc taagaagcac tagaggccgg gcgttctttt ttccttttat cccttctatg 2123041 gtacactaaa agcacattaa aggaggaagc accttgtatc cgaaagctta tatagattat 2123101 ctcgttgagt ttcatgcgac acgggattat tttgaatgcc atgaaatatt agaagaatat 2123161 tggaaggaag atccgccaaa gaaacgaaaa cgctattggg tgggctttat tcagcttgca 2123221 gtggctttat atcatcacag aaggcagaat acagccgggg caaaaagact gatggcgaac 2123281 agcatccgga ttcttcaagc agaacaccgg gcagtcgaag acttagggct tgatcatggc 2123341 cgtttgctcg aacttatgca atcggtttac gaacaaatcg aaaccgtctc tgcctataaa 2123401 agcattatac tgccaatcaa agatgagaaa ctggaggaag catgcaggat cgaatgcagg 2123461 aaaaaaaagt atacatgggg gcagcccagt gcactcagca acatatttct tatcgacaaa 2123521 caccgtttgc gggatcggac tgacgtcatc cgtgaacgtg aaaaagaaat agaacgcaga 2123581 aaaaaaagca gagactgatc acagcctctg cttaattatt gtatgaaatg tcttgatcct 2123641 gctgaccttg acaacgttcg aaaaagctct gcgttaattc atttggaacc agtacttgcg 2123701 ttttgaataa atgctttaaa gcatccatca tctgttttcc gattccttga tggcgatgag 2123761 aaggattcac actgatatgc cggatctcaa cctcagaatc ctttttttcg actccgattg 2123821 ctccgacgat atcctcgtcc tctttccaaa gaaagagctg gcggtctgta tccgtttcgt 2123881 agtccttaat tgtctgctga agctgcttaa ggtctttttc attcggcata aacgaaagaa 2123941 gccccatcgc aatcttttca aacgattttt tataacgaat taacataaaa acccctctat 2124001 atccaaaatg tccagtctgc tattaacgga tacgaatagg tgatccgttt tctcacatta 2124061 tatcattttc gccatatttt taaactgttt tcagcaaatt attcaaatga gcggtttaaa 2124121 tttgccattt caatggcaga aacagcacaa tctacacctt tgttgcccgc ttttgtgccg 2124181 gcacgctcga tagcctgttc gatgttttca gttgttacaa ttccaaagat gacaggtaca 2124241 ccagtagtgt ttgctgcttg cgcgatgcct tttgcagctt cattgcagac ataatcgtaa 2124301 tgtgtcgttg cgcctctgat gacagtgccc aatgtgataa tagcatcata tttttttgtt 2124361 tccgccattt ttttcgcagc aaacggtatt tcaaatgcgc ctggaaccca agccacatca 2124421 atgtcatttg tgtctacgcc atgtctgagc agcgcatctt ctgctccgct cagcagcttg 2124481 ctcgtaataa aatcattaaa tcttcctact acgattccga ttttaagacc tgtaccaact 2124541 aaatttcctt gtatgatatt catatgattc ccatcctttt ttgtgatatt tgtgattaga 2124601 aatgaagtaa atgacctagc ttgttcattt tggtttgcaa atatttttta ttgtgttctt 2124661 tcgcctccat ttgaagcggc actctttctg aaatactgag tccgtagcct tcaaggcctg 2124721 cgatttttcg cggattattc gtcaaaagct tcatattccg gacaccgagg tcgcgtaaaa 2124781 tttgtgctcc gatgccatag ttgcgaagat ccggcaagaa tccaagcgcc tcattggctt 2124841 ctacggtgtc atagccttgt tcctgaagct tataagcttt taatttattg attaaaccga 2124901 tgcctcgtcc ttcttggcgc aagtacagga gcactccacg gccttctgcg gcaatttggt 2124961 tcagcgcggc gtgcagctgc ggtccgcaat cacagcgatg agagccaaac acgtcacctg 2125021 tgagacattc tgaatgcacc cggaccaata ccggttcttc tccgaacggc acatctccca 2125081 tcacaaatgc gacatgctct tttccatcta cctcatttgt gtatccataa accttaaatg 2125141 tcccaaaatc agtaggcagc gtaatgtcaa cttcacgctc gacaagtgtt gtcagattgt 2125201 aacggtattg aatcaaatcc ttaatggtga tcatttttaa ttgatgcttt ttcgcaattt 2125261 caatgagctc aggcactctc gccatcgttc cgtcttcatt cataatttca caaatgacgc 2125321 cggctcctgg agatccgcaa gcttcagcaa gatcaacagc agcttctgta tggcccgctc 2125381 ttttcaggac acctcctttt ttcgcaatca gtggaaaaat gtgccccgga cgctgaaaat 2125441 cagatggcac ggatttgctg tccagcaatg cttgaacggt aaaagatctt tcttgagcgc 2125501 tgatacctgt cttcgtttca cgatggtcta tgcttacggt aaatgcagtg tggtgagagt 2125561 ctgtattatg ctcaaccata gggtgaagat caagcctgtc tgcgatttcc tcactgagcg 2125621 gcgtgcagat cagtcctctc ccatgtgtcg ccataaagtt aatgacttcc ggcgttgcat 2125681 gctcggcaag agccacaaag tctccttcat tttctctgtc ttcatcatct acaacgatga 2125741 tgacttcgcc tttttttaaa gcgtccagtg cttcttctat cggatgaaac atgcaaatct 2125801 tcctctctaa aagccgtttt cgcttaagaa ggcttttgta atggtttgtt gggtcttatt 2125861 ttcattggct ttatgcaaaa atcgatacat atattttccg atcatatcgc attcgatatt 2125921 cactttagag ccgatcgttt tttctgaaaa gatcgtttcg ctgatcgtat gcggtattaa 2125981 ggagatcgtc actgtgtctt ctgtcaggcc gaatatggtt aagctcacgc catccacagt 2126041 aattgatccc tttaaaacca atgtttttgt taatgacggg tccattttta aatcatagta 2126101 aactgcgttg cttttctctt caattcgtgt gatttccgca gttccgtcga catggcctga 2126161 gacgaaatgg cctccgaaac ggccgtttgc cgccatcgct ctttccagat ttactttgct 2126221 tccttttgtt aaatcattca gtgacgtagc tttgactgtt tcaggcataa catccactgt 2126281 gaattgattt tttgtaaaat cagtgacagt cagacaaatg ccgttcactg caatgctgtc 2126341 gccaagatga acatcctcta aaatctttga gcatttaata gttaaggcca ttgcatgccc 2126401 tgcttttttc atggattcga ttgtgcctgt ttcttcgata attcctgtaa acatggtcac 2126461 catcctattc ctttgtcggt tttgccgtca gtttgatatc acggccgatt tgggttatat 2126521 cagtgaattg taataagggg acatctttca ttgattgaaa accttcaccg gagattaagc 2126581 tgggagcatg cgttcctccg attagtttag gggcaaaata gaagatgatt tcttgaaaac 2126641 agccttcttt gacaaagctt ccgtgaacag ctgaaccgcc ttccacatac accgacatga 2126701 tgccttcttc cgctaggatc ttcaaaacat caggaatttg aatgcgctcg gtttcaagtg 2126761 taaatatgtt cactccgaaa gctgaaagcc gttttttctt ttcctcgtct gcgcgtgccg 2126821 tcgtaaaaat ccatgtcggc gctatttgat cgcaaatcac tttagcgtcc tcaggaatcg 2126881 agagtacggt atcaagtatg acccgaaccg gctgttttgt tacattcggc agtctgcagg 2126941 ttaagctcgg attgtcggct ttcactgtgc caactccgac taaaatgctt tggtgtgttt 2127001 tcctgtattg ctgagcatcc tgtcttgcag cctctgacgt gatccatttg ctgtcacccg 2127061 tgctggtagc tatcttgccg tcaaggctgg cagccgcttt tagcgtgacg tacggaaggc 2127121 ctgtcctcat aaagtgcaga aatttttcat tcagcctctc cgcctggtct gccaggatgc 2127181 cttcccttac ctcaatgcca gcttctttca tcatgctgat ccctcttcca gccacaagcg 2127241 gattaggatc tctcatcgcc acgaacactc ttttgatacc agagttgata atcaattctg 2127301 cacatggcgg tgtttttccg taatggctgc acggttcgag tgtaacgtaa atgtcggcac 2127361 cctctgcatg tgctccagcc atatggatgg catgaacttc tgcatgagct tcaccatatt 2127421 ttaaatgggc gcccattccg acaatttgtc cgtcctttac gacaacagcg ccgacgagcg 2127481 gattggattc ggtctgtcct tcgccctgct tcgcaagatc taaggccagc ttcatataat 2127541 actcttccat ttgtttccct cccctctttt gttatttacc gtcaaaaaag ccccgaattt 2127601 ataaaaaatt cggggcttta ggtattttac gcaataggaa ataacactat gcatttttaa 2127661 acattttgca tagcggctca tcatccttct cccatccaga ctttcactgt cggcttcagc 2127721 ttaaactgaa tccaccgcgt gcttatgcac acgggtcacg ggctctaaag caaatgtgct 2127781 ttactaccgc cggtcgggat ttccaccctg ccccgaagga tacaatcttt attcatttgt 2127841 ccttattggt tattatagcg atccttttta aagtacgcaa tgaaataaac ttacaatttg 2127901 agaaaaacaa aacatcaccc ttcgatccga aaggtgatgt tttttaatca ttcacttttg 2127961 caaccttgat taatccgtcg atccgctttg atttgctgaa gtaagcctta atcttgtcac 2128021 cttcttttat atcagataaa tcctgattta atttttttcc gttgaagatg attttcgttc 2128081 cgttttctgc tactccatga tactctgagc cgtcaatttt cgtcacttta tattcctgga 2128141 tggtgtattc ctcttcttcc gaggacaagg tttgtccaat tgctgtcgga acatccttca 2128201 gctcaatatc atttatgtac atataaccgc ctgcaagtaa aagcaaaagc actaacagaa 2128261 tggtaatctt ggtttttatt cttcccattt ctaaacctcc agccaatatg aatctattca 2128321 ttcatatgag ttattccttt ttttcatgaa taaaaaaccg taaattctcg taaattatta 2128381 atataacgat gcataacggg aatatgtttc acatttctgc aaaaatttct tttctataga 2128441 tatacgaatt tatgttctgt ttttagggga tgaccgtaaa aaagatataa aaaaagcagc 2128501 cccaatggga agctgcttga tcctaatttg ttttgcgcat ttcgttaaac gggtagaaaa 2128561 caaactttga cgtacccgca atttgttttt tcgtgaagag gccaaggccg ttacggctgt 2128621 ccatggaatt gcgacgattg tcacccatca caaaatactt gttatcaggc actttaaccg 2128681 ggccgaaatc atcggtcaaa tggtcaaaac cgtcctgttt cgctctcttt ttattagccg 2128741 ccaaataagg ttcgtccacc tttttcccgt tgatatagag ctggtcattt ttcatctcaa 2128801 ccgtatcgcc gggaaggccg ataatacgtt tgacatagtg aacatcatct ccgtttaaca 2128861 cgacgatgtc tcctctatca aactcgccga tgtatttgac tgtcatatta acaaaaaccc 2128921 tttcacggtt gtgaagtgta ggatacatag agtcaccatc aacgacatac ggcgcaaaaa 2128981 taaagttgcg gatgagcaaa gcaagaacga cagcaatcac aattgctttt gcccattcta 2129041 atattgactt tttcttcgaa acattttctg atttcaactg atttcctcca ataaacaacg 2129101 gtcttcaatt tatgttatca cgaatcgaaa aaaaatccca ttaggaccat tgaagtgatt 2129161 ttacaaactg ttaatcttca tcttctaccc acatcatgcc tattttttct tgtcgatcat 2129221 aactaggcct gaaaatattg aaagaaatga atcgcataat tcagaagcga tggactcaga 2129281 agaaagagag ttctcatatg caaaatcttt agatcgtata taaagcatga ggttacgggc 2129341 agtttgttca tttactgcat tccattgatc tcccagtcca tgatacccat ggcacttgac 2129401 aaaacaatta acgtcatgaa ggttactgga atgtttgcgg caacctattt cacaggtgat 2129461 aaccgcaccc cgttttttgc tttcataata tgtttaaaat cattcaagct cgaaaacatg 2129521 gatcagcctc caaaaaataa atccaatata ttcccggcag ttgaagactc tttattataa 2129581 aactctgaat atccgcagtt cttacagtaa accactagaa atcggttatg ctgcacgtca 2129641 aacagctttg ataatcccgt gccggttgta gctatttctt tttgtccggc ttcagtacta 2129701 ccgcatttta tacagccttt gttgttcata tcgcgatctc cttttcatta catcacgttt 2129761 gtttgattta ttttactaca aaatatcaat cccaatgacc cgtactactt taaagtttac 2129821 ttaattttga ttacatacta attgggttcg tttctcagct tggtaaatct tctggagaaa 2129881 cggaaaagct ccatgaccaa aacattcaaa ctcagccaaa caccgccgaa ggcgtaaccc 2129941 gcagcaacat cactcggata ctgctcataa agtacacacg gctcagcccg atgaggaata 2130001 aaacgataat aaacaaaaaa atgcaacagt ttgcagacgc gtcttgtgag aatgacgaac 2130061 aaaaagataa gcacaaaaac caaaaatgac aaatgccgtt aaagtctgtt cgctcgggaa 2130121 tggatataat acatgacttt ccaaaggagc gtgaacagga tgaagggaat gaaagagccg 2130181 tctgattccc tcttcataaa gctccccacc aatgactagg aaaaataaga aagagagttc 2130241 gattttccga tcttgccctc tgaataccgt ccaaaaaaaa gttagaacaa taacggctaa 2130301 cagaacacct ctcgacgcaa aagctttctg aattgcagct gggcccagtc tatacccgat 2130361 ccaatacgac atgctcactc ccacagctcc ccaatccggc cgctaacatg cttagcaccc 2130421 agtttaactt ttcttgaaac acgagaacac cggcaaactc tcccggtcca agtaaagcta 2130481 gaagctctaa catcaagaca ataaacaaga cggcatatcc gtactgttcg agcaaccccg 2130541 tcaaaacttg catgtgattc tccttaaact tttttgttct tttatcattc ccaatccact 2130601 ttttgtataa tcagcacaat tttatcttca gtcgtccaac aacattgtct atggcgggat 2130661 cttctctcat acattctttt ttgacatagg aggagcaata gcatgaaatg ggaggaaaca 2130721 aaagatacgc agggagtttg ccaaaatttt gggcagttcg ttctgccacc gagtcaggtg 2130781 tttgtttgcc cacctcatcc cttgtcaatt ccccattttt cccgtttgag gttcgaaatg 2130841 gtaaagtatt tcacttagtt tcttacatga agaggtaaat tctttgctca ccgaactagg 2130901 atagcggcgt atggcgattt ctacattgca taaccactgg ttatttagtg agccgtgagc 2130961 aatgtatatg cactttgagt cagcacagga tgatcctatt acattcgcca gaaaagcagc 2131021 tgccgcattc agagtagtta aaagaataga cagatatctg ggcttccgga agctttaaag 2131081 gaggctcttt tttcgagcat ttttataaat caataaaaac aggcatctcc taaatatttt 2131141 tgccgataag tttacgctaa tcaactctag cactaataca tataaaaaat agaatgatat 2131201 gaaaggagac ttgatagtat gattgattat cctattaata taaacaacgt ttccgggaac 2131261 agtgtaatta acgtaggcgg cgcttttatg atcaggcctt taactttgtc caaatctgtg 2131321 tttggctccg gaggtttaaa cacaggaatt gtctttgaaa ataactttgt aagcaaagct 2131381 aaaatgatta atcatcaatt tactgatcaa aacgtcacca aaacttttta atgtattcaa 2131441 tacacggggg tcactaacta aacacctggt tttgccaacc gccatcagca ttcggcggtt 2131501 ttttattgaa catttttggc caataaaaaa agcttcctct ctaagaggaa gccttttgcc 2131561 tgccgattag ccttctacac gaacttcttt catgacatcg ccattagaca tgtttttcgc 2131621 gaattctaat ccgcttgtta ctttaccaaa tacagtgtga acaccgttca aatgaggctg 2131681 tggctcatga acgatgaaaa attggctgcc gccagtgtct tttccggcat gtgccataga 2131741 aagtgcgccc gcctcatgtg tatgcgggtt gccttctgtt tcacatttga ttgtgtatcc 2131801 cggaccgcct gtaccagttc cgtgcgggca tccgccttgg ctgacgaagc cagggatcac 2131861 tcggtggaat gtaagcccgt cataaaagcc ttcgttcgca agcttttcaa agtttgcaac 2131921 agttccaggt gcagcttcag gataaagttc aaattcaatt ttgttcccgt cttctaataa 2131981 aaagtaacct gttttcaatt gtatgcctac tttctttatt ttaattttca aaggagatta 2132041 tgtataggtt atagcctgtc tctccttgtc gcggctatta taccacacct ttcgggggaa 2132101 aacgaatctc ccgagcttta ctaaaaaata aaaatgaaac ctgaatctct ttatctccgt 2132161 ctaacctaac ggaactgtat ttttcatgat tcaggtcctc acaaagcagc actatccagc 2132221 tgcttgtgaa attgaaggag gtcaaactgc tttgaagaaa atttggattg gaatgctggc 2132281 agcggccgtt ttgctgctga tggttccgaa ggtcagtctc gcggatgccg cagttggaga 2132341 tgtcattgta acactgggtg ctgatttgtc agaatctgac aaacaaaaag tgcttgatga 2132401 aatgaatgtc cctgataatg ccacaacggt aaccgtgacc aataaggaag aacatgaata 2132461 tttaggaaaa tatatatcga acgcgcaaat cggatcgaga gcgatttctt catcgtcaat 2132521 caccattgcc aaaaaaggct ccggattgaa tgttgagacc cataatatca gcggcatcac 2132581 agatgaaatg tacctgaatg cactgatgac agccggtgtt aaagatgcga aggtgtatgt 2132641 tacagcaccg tttgaagtat ccgggactgc cgctttaact ggattgatta aggcgtatga 2132701 agtttcttct gacgaagcga tctcggagga tgttaagcag gtcgccaacc aagagcttgt 2132761 cacgacatca gagcttggag acaaaatcgg taacgaaaat gcggcagccc tgattgcaaa 2132821 aatcaaagaa gagtttgcta aaaacggggt gcctgataat aaagctgaca tcgaaaaaca 2132881 agtggatgac gcagcttctg atttaaacgt cacacttaca gacagccaaa agaatcagct 2132941 tgtctcccta ttcaataaga tgaaaaacgc tgacattgac tggggacagg tcagtgacca 2133001 gctagataaa gcgaaagata agattacgaa attcatagaa tcagatgaag gcaaaaactt 2133061 catccagaaa gtcattgatt tcttcgtatc tatctggaat gcgattgtat ctatattcaa 2133121 ataagaaaag cgccgaaaaa tcggcgcttt cttttattgc tttacacccg ttttaaatgg 2133181 cagatcaagt tttacaatat cttcgtatgt ttctcgcttc acgactaaat gagcctcacc 2133241 gttttcgaca aatacaacgg cgggtctcgg aatacggtta taattgttgg ccatgctgta 2133301 tccataagcg cctgtacaaa aaacggcaag aagatcgcct tcttttactt ccggcaggtc 2133361 aatatcccaa atcagcatat ctccgctttc acagcacttt ccggcaattg ataccgtttt 2133421 gtcatgcgct tctccgatcc tgttggctgc cgcagcttca tatttagctt ggtaaagcgc 2133481 aggacgaata ttgtcgttca tgcctccgtc tacagccaca tattggcgga cacccggcac 2133541 ttctttttga gagccaaccg tataaagagt tgtgcctgcg tctcccacga gagaacggcc 2133601 cggttcgatc caaatttccg gaatgtcaaa accgtaacgg gaagcatttt ctttcacagc 2133661 ttcgataatt ttttcaacgt attcagtggc atgaagcggt tcatcatctt ccgtataacg 2133721 aatgccgaaa cctcctccaa gattcagcac cttggataca aatgaatatg aatctctcca 2133781 ttcgtctagt tttttgaaga ttttttccgc tgctaacaca aaaccggccg tatcaaagat 2133841 ttgcgagccg atatggcaat ggacacccag cagctgaatg tgttccgatt gtaatacttg 2133901 ttcaatggcc cgttcagttt gtccgttatg aagatcgaaa ccaaactttg aatcttcctg 2133961 gcccgttgta atgtagtcat gcgtatgcgc ttctactccg ggcgtgatcc gaagaagaac 2134021 atcgatggag tgacccgttt ctttacatag gtcttcaaga agcgcgattt catagaaatt 2134081 atccaccaca atgcagccga tgcggtgctc aagcgccatc cgcagttctt ccctgctctt 2134141 attgtttcca tgaaagtgga tgcgttctgc cggaaagcct gctgcaacag ccgtatatag 2134201 ctctcctccg gatacgacat ctaaagaaag tccctcttcc tcagcgagct gaatcattgc 2134261 gactgatgag aatgctttgc tcgcatatgc cacctgtgct ttcagccctg cagaaataaa 2134321 cgcctgctta aagcttttag cacgctcacg tattaaagcc acatcatata cgtaaagagg 2134381 tgtaccatat ttctccgcta aatagagagc atccacacct ccgatttcta aatgaccatg 2134441 ttgattttgt ctgcttgtgc cgtgtaagaa caatgtcatt ccctctttct ccgcttatgg 2134501 atgaaaggac agttttatgg actgtccctt cataattaag acatacatta tcatactctt 2134561 cagtcagttt caatgcgatt atgaattggt aggctgcctt aagcgatttt tggggtgaac 2134621 gatgctgggt cttacttttg cgccaggttt cgctgtgcgg acaagaacct gccacagcgc 2134681 ctttccgtta aagggaatca gcggccataa gtacggtgtc tgaagggatt tgatgcttgc 2134741 catggcaata attagcactg taaatccgat gacgagccct tttatatgaa ataaagcaac 2134801 gagtatcatg aggacaagac ggctcatttt gtttgccaag cttaattcat aactaggcgt 2134861 cgtaaaggtt ccaatcgccg caagtgagac gtacagaatc acctcaggag aaaaaaggcc 2134921 gacctcaatc gcaatctgcc cgatcagaac agcggcaatt aaacccattg ctgtcgataa 2134981 agccgtcggt gtgtgaatgg cagccattct gagaaactcg attcctaagt cagctaaaaa 2135041 tatctgcagg atgatcggga tatgcgtatc tttatttaaa ccgataaatt tcatgttgtc 2135101 cgggagcaga tcaggctgaa gcacaaagag aaaccagatc ggaagaaata aagtagaagc 2135161 aagaataccg aaaaatctta cccatcttaa aaaggtcccg actgaaggcg cctgcctata 2135221 ttcttcagca tgctgcacat ggtgaaataa agtcgtcggg gtaatgatca cactcggcga 2135281 tgtgtccact ataatgataa catggccttc tagaacatga tttgcggcca catccggtct 2135341 ttctgtatag cgcacgagcg gaaaaggatt atagctttga ttaacaatga attcctcgac 2135401 agttttgtct gccattgtta atccatcgac atcaatggat gcaatttctt tttctacgat 2135461 ctcaaccaga tccggatcag ctatatcttc tatataacaa atgcttaaat ccgtctttga 2135521 ccgctcacca actttagtca tcttgactcg aaggcgttcg tctctgatcc gccttctgag 2135581 aagggccgta ttgacgacga tattttcaac aaatccgtct ctggctcccc tgaccacctt 2135641 ttccgtatca ggttcttccg ggtttctgcc cggatagctt ctgacatcaa ttataaatgc 2135701 gaagcctgca ccttcaacaa tgacagcgac gagcccggac agcacttggt cggtggtttc 2135761 atccaaggtt tttacttttt cgacctgggc gttaagcagc ctgttttcga cgatgtcgac 2135821 cagctcatca gggtcttctt tccgattgtt aatggcaaca agctctctca ttaaatgaat 2135881 aatataggct gtatcgcata atccatttag atagtaaagc tggatctctt tatctaaaat 2135941 cgtgagcttg cgaacaccta catcatagct cgtccccatc ccaacacggt ttttgaaata 2136001 ctcttcattt ttagctggat tccgataaac ccgaattttc tcttccttgt ggtccggcat 2136061 gatacccgct cctttctaaa ataaactcga ccgctttcat ggtgattggc gacccttttg 2136121 agatatcgtc ttttctgccc attttgccga tatccccgat accgacaata agcgggagat 2136181 caagtttatc aaggcaatag actgtatctc cactcattct gtggtcatca aattcccttt 2136241 ccccgacttt atcgacgccg tattcagtta tttctccatt gcggtcaatg cttacatcga 2136301 ccctggtcca ttcagcctga tgtgtttttg acgcgaccgc aatcacaccg agcacttcaa 2136361 tagacggatg ggttgcgaca taggttagag cggcttctcc cgggccctct ccttgaaggc 2136421 cggagtcgtc aaacatgaca aatacaggat catacggtgc tgaggcgatc agcttgacaa 2136481 gctcggcgcc gctgcgggtg gaaggattcc cttttgattg tgaaatacat cggcctccca 2136541 ctttgcttgc ggcgtattca attgttttag cggcataaac atccccgtct gttaccagta 2136601 tgaccttgcg ttttgtcgtc atgtcggcat tatcctttcg gtttgaaaat aacagctacg 2136661 ataaaggcga aaagaatagc ggctgagata ccggccgagg tcagctcaaa aatccccatg 2136721 ccgattccga taaatccgtg tatatgcgcc tgatgcatgg cgccgtgcag aagactgtga 2136781 ccgaagctga cgatcggaac ggtggcgcct cctccggcaa attcaataaa tttatcgtaa 2136841 atgccgaaac catctaatat tgcaccgatt acaacaaatg atgtcatgac atgagctggc 2136901 gtcaatttaa aaatatccaa gagcagctgg ccgacgatac agatggcccc gccgcagaca 2136961 aaagccaaaa ggtagtccat attaagatgc acctcctgca cgctcaaata caaccccgtg 2137021 ggcgatagtc gggatggttt ctttttgctg gatcatcgtc gggcttaata gcgccccggt 2137081 cgccacgaca aatacacggt ttagttttcc ttctctcagc tgcttaaaaa tatgagagta 2137141 ggtgacaacc gctgaacaag cacagccgct ccccccggca aagacctgct gatccggagt 2137201 gtaaatcaga agcccgcaat catcatgctt tgtgccgact ggatatccat cttcttttaa 2137261 aatgtctttt acgattggag aaccgacgcc tgacaggtca cctgtcagga ttagatcata 2137321 gtcatccgct gtccggttga gatctttaaa gtgctgctta atcgtatcag ctgcagccgg 2137381 agccatagcc gatcccatat caaaaggatc tgtaattcct aaatcagaaa ccttcccgac 2137441 agtcgcactt gtgatttgga tatcacccgg tgtctgactg atgacaactg caccgcttcc 2137501 ggttacagtg gaggtagcag tgtccggttt ttggcctccg tattctgtcg gatagcgaaa 2137561 ctgtctttcc gcagttgcat tgtgactgct ggtggcagcg agtgcccttt tggcaaaccc 2137621 tccatcaact aaggctgatg cgacagccac tgtttccatt gatgttgaac aggcgccaaa 2137681 catacaaaga aatgggattt tcaagtgtct tgccacatag ttagccgtca cgttttggtt 2137741 cagcaagtcg cctgccagca ataggtcaat atcatctttt gtcagattgt ttttttgaag 2137801 tgcaacatta acagcgtctt ccatcagctg ccgttccgcc atttcccagc ttttttgatt 2137861 acaatgcatt tcgtcatagg ttttatcaaa taaagagcca agcggtccgt ctttttcctt 2137921 tggtcctgct gccgttcccg ctgagttgac aaatatggga tgttcaaata cccaggtttg 2137981 ctttcctgtt aatttcattt tcttctcctc ctatgacatc agtttctcaa aagcaaaccg 2138041 aatcattcca acgatgtatg cagctacaac tccgaaaaca ataacatttc ctgccagttt 2138101 aaacatattt gtcgctactc caagcactaa tccttcgctt ttatattcaa gagccgcact 2138161 tgccatactg ttggcaaaac ccgtgacagg tacggctgaa cctgcgcctg cgaattgtcc 2138221 gattctgtca tagattccaa accctgtaag cagggcagaa attaatatca gcgttgcagc 2138281 tgttggattc cccgcagttt tttcattgaa atcaaaaaaa tggatataaa aattttgcag 2138341 accttgcccg attgcacaaa tcagtccgcc cactaaaaag gcttttacac agttccagac 2138401 gtaaggcggc ttaggctgat atgttttcac ttttgatttg taattttctt ttatgtttgt 2138461 catcttgaaa cctccttatg aatggtcaat aaagtacagc cagtgaaata aagatcccgc 2138521 gattttccca atcacgatgg ccattaacag aataatgatt ttacttctga gcccgattcg 2138581 tttcgccaaa atcggcagga catttaaaac ctctgtaaga gcagccgcta gcatcccgac 2138641 gaacaaacct gccagaagcc cgaccggcac agctatccat tttgttagat aaagatgatt 2138701 catatgaagc gtctcccatc ccccgcaaac cgcgccaaga ataacagccg cttcataagc 2138761 ctgaacaaat ctcattgttt tggtgagctg catcagccgc ggaatgattc ccattacggt 2138821 taaaaaagca acgaaacccg cccccaccgt tatgcctccg ccgagcccga caaaaatgat 2138881 gaacaataca ctaacgatca tgcagatcct ttatggtttc ttgattctca tgcatggcca 2138941 catattgatc gagatcaagc tgatagttaa acatctcaac ctccagcggg ctgggctctt 2139001 catttaggcg ctttttaaat atgtggttaa aaaacacgat catccccagt cccaaaccga 2139061 tgctgtatgg gatttgaagc aaatatggat agtcattcct ctctccggtt atgatttcat 2139121 atagtgcgat atgaacatct ctcatgctta catcctcatg aaagttcatg atggcaagac 2139181 acgatccaat aaacagaagc agccagacac cgataaatag aaccgttgat aaatttcgct 2139241 ttcgatactg aatttcaaca atggtttctg ctccgcctac ggtttgaaca tcaattgtcg 2139301 ggtcttgtaa atgaatggct ctgaggactt gtatgatatc cagaattacg atatttttat 2139361 ctttttcgct cacctgataa agcggcatag ccgaaagttt ctttttcagc tgaagctgcc 2139421 cttctatttg cgcggcatct ccaacggtaa taatatcccc tggatgtgcc agcactcggt 2139481 ggcgaagccg gataaatatt cgtcgttcca tcattgatca ccatctttcg gtggttatat 2139541 atgtagtatg tggttcgatt ttgttctcat tcatccgctc gaaaagacca taaattacca 2139601 cgcttttgca caaaaaagct agcctgcact gcagactagc catccgtatg atccatttga 2139661 accttgatct gttttaatat tttcttttca agcctggaaa cctgcacctg agagatcccg 2139721 agccgctcag ccacctcgga ctgtgtctgg tctttataat atctgagata gacgattagt 2139781 ttttcccttt cctccaaatc gctgatcgct tctttcagcg caattttgtc aaaccatttt 2139841 tcttctgagt tgtcagcgat ttgatcaagc agggtaatcg gatctccgtc attttcataa 2139901 acggtttcgt gaatcgaaga tggagccctt accgcctctt gggccagtac aacatcctca 2139961 gcttcaatct ccaaatggtc agcgatctcc tgcaccgtcg gcactctgcc cagtgttttc 2140021 gaaagctcat ccttcgcgcg ccggattttg tttccaagct cttttaatga ccgtgatacc 2140081 tttacggttc cgtcatcacg gataaatcgt tggatttctc cgataatcat cggcactgca 2140141 tacgttgaaa aacgcacatc ataggttaaa tcaaatttgt caacagattt taacagcccg 2140201 atgcagccga tctggaagag atcgtcaggc tcatatcctc tgtttaaaaa ccgctgtacg 2140261 acagaccaaa caagacgcat gtttttttct atgaggaggt ctcttgcctg ctggtcgcca 2140321 ttttggcttt gtttgattaa ttcctttact tcatgatcct tcagctgagc gtttttgccg 2140381 tttttcttaa cctccacatc cataacaaat ctccttaatt acaaagcgct ttgctttttg 2140441 ataagtgctt tgttaagcga atcgttgttc ccatttcagg cgatgaatcg atactgacat 2140501 catccatgaa attttccata atggtaaagc ccattccaga gcgctcaagc tcaggcttag 2140561 tcgtaaatag aggctgacgg gcttcttcaa gatctgtaat gcctaagcct tcatcacgaa 2140621 tagtcatata tacgacatga tcttccagcg tcactgaaat gtaaactttc ccttcacagt 2140681 tctcttcata tccatggata atcgcattcg tgacagcctc tgacacgact gttttgattt 2140741 cagtcagttc atccattgtc gggtccagct gagctataaa tgaagcaact gtcacacggg 2140801 cgaacgattc attctgactg agggcagaaa actcaaggtg catttcattt ttcatgatgc 2140861 cacccccagt gtcaggagtg cctgctgttc agattgttca aatcggataa ttttaaacag 2140921 acccgacata tcaaacaatc gcttcaccgc aggagagata gcgcaaacaa ccatttctcc 2140981 gccaatttgc ttaatttgct tgtatcttcc taaaataacg ccaagccccg agctgtccat 2141041 aaaggaaagg tcctccaagt tcagcacgat atggcgaata tcatccttct ccaatgattg 2141101 agtcactttt tgcttcaggg tttcagccgt atggtgatcg agttcgcctg ttaatcgaat 2141161 acaaagcaca gattctttga cattcatgtc aattccaagg ctcatgctca ttcctccttg 2141221 atatgatcgg ataatgagtg tttcgatttc gacggaatga attccttcac cgtgacaaaa 2141281 ctagtggtca ttcggcataa ttacttaaat tttgtccagt ctcccatcgt ccgctttaag 2141341 aatgtgataa acccggcttt cttcatatct tcttttgcag caacaggact ttcagcgagt 2141401 acttctccat cctttttcag aacaagagtg ccaagctctt ggcctttttg aatcggagca 2141461 ctaatattgt ccttcatctt gatttctttt ttcacatcgt tcatatcctc gccttttttc 2141521 gtcaatattg aaatcggctc agatgtagtg agttcgataa atttttgttt cccttttttg 2141581 acctttactt ttgctactgt ttgatttcgt ttatataaag gatgcgtttc atattggcta 2141641 aaggcgaagt caagcatttt tgtcacttgc gcgtttcttt ctttaggcgt gctcgctccg 2141701 aatacaaccg ctatggcccg catgtttcct tttttagccg aagcagtcag acaatatttc 2141761 gcttcgcctg tatagcctgt ttttacgccg tctacaccag gataaaattt gataaggcga 2141821 tttgtattta caagccaaaa ctttttatct gtattttcac gcagataatc ttcatacgtg 2141881 ccggtaaact tcgtaattga ttcgtatttc aataattcct tagccatgat tgccatgtca 2141941 taagcagagc tgtagtgtcc ttcctcggtc agtcctgttg ggtttttaaa ggatgtattt 2142001 ttcaatccca gctcttttgc ttttttattc attttcttca caaattcttc ttcagagccg 2142061 gaaataaatt cagccatggc gacggaagcg tcatttcccg aagcgattgc gatgcctttc 2142121 agcatttctt tgacagtcat ttcttcgccg ggctcaagga atatctgtga gccgcccatt 2142181 gacgccgcat gctcgcttgt acggacctta tcactcattt tgattttgcc tttatctaaa 2142241 gcttccataa tcaaaagcat cgtcataatt ttcgtcatgc ttgcaggcgc cagtctctca 2142301 ttgctgttct tgttgtaaag cacttttccc gtgtcacgtt ctatcagcac cgcagacttc 2142361 gcttcatgag caagctccga tgtacgtttt ccgtcttgtt ttgcaaatgc agacggtgca 2142421 aatgtaagca gcattatacc aatcaacaaa gtggataaaa gacgtttcat ctcaaaagcc 2142481 ctccatttca taatcctttt tattttttcc aagcgtgatg gttttatacg ccactgatgg 2142541 aaaatgtttc gaattttggg cataaaaaaa gacagctgtg tgatatcaga cacagctgtc 2142601 ttttggtcct gcattgattc atatttattc gtactgagcg acgatcgctt taacaagctt 2142661 taagaatcca gcttttactt tttcggtcac ttccataact tcatcgtgac ttaaaggctg 2142721 atccagaatt ccggctgccg cgttagagat gcaggaaatg ccaagaaccc gcattcccgc 2142781 atgattcgct acaatgactt ccggaacagt agacatgccg actgcatcag agcccatcgt 2142841 tcttaagaaa cggacttctg ccggtgtttc gtaagaaggt cctgtcacag cagtgtacac 2142901 gcctttttga attgggatat taaggtcttt cgcaatcttt tcagccaggc tggacagatc 2142961 tttgtcatag gctgaagaca tatctggaaa tctggcgccg aaatctgctt cgtttggccc 2143021 gattaacggg tttgttccca taaagttgat atgatcggta ataatcatta aatctcccgc 2143081 acggaattca gtgttgacac cgcctgcggc atttgtcacg atcaacgctt ccacaccgag 2143141 cgctttcatc acgcgtacag ggaatgtgac tttctccatt gagtagcctt cataaaaatg 2143201 aaagcggccc tgcattgcaa tgacggaaac tccttcaaga gtgccaagca caagctgtcc 2143261 ggcatgccct tcaacagtag ataccgggaa ttcaggtata tcttcatatt tcagcttgac 2143321 cggattttcg atttcgtccg ccaaaatgcc aagacctgag cctaaaataa ggccgatctt 2143381 tggagattcc ggcaggtttt gtttaataaa agcggctgcg cgttcaattc tgtccttcaa 2143441 gaaacagtcc ccctattgta ataaagataa aaagcttttc ccgtatttcg gtttatttgt 2143501 ttggaaatta tcagcgatcg ttgcgccaat atcggcaaat gtatctgcaa gcggcagcat 2143561 ttgcgctttc ttatgttttt tgctgtaagc gagaatcggc acatactcgc gtgtatggtc 2143621 agtcccatga tgaatcggat cattgccgtg gtcggctgta ataattaaca gatcgtcttc 2143681 tctcattttt tcaaacactt ccggaagccg cgcatcaaat tcttcaagcg cgcgtccgta 2143741 gccttcaggg tcacggcggt gtccgaataa cgcgtcaaaa tcaacaaggt tcgcaaagct 2143801 cagacccgta aaatcttctc ccagcgtatc gatcaccttg tccattccgt ccatattaga 2143861 aaccgttctg cgtgaagaag taatgccttc tccgtcgtaa atatcagaga ttttaccgat 2143921 tgaaatcaca tctaagccgc agtctttcaa ttcattcatg acagtgcggt caaacggctt 2143981 cagcgcataa tcatggcggt ttggcgtccg tttgaattga cccggctctc cgacgaacgg 2144041 ccgtgcaata atgcggccaa ccatatattt cggatcaagc gtcagctctc tcgccgtttc 2144101 gcaaatgcga tacagctcct caagcggcac aacctcttcg tgagcggcaa tttgcagaac 2144161 agagtcagca gacgtgtaaa caattaaagc ccctgtctcc atgtgctcct ggccaagctc 2144221 atccaaaatc gctgtgccgg aagccggctt gtttccaata attttgcggc cagatctctt 2144281 ttccagctct tgaagcaatt catcaggaaa gccttccggg aacactttaa acggtttatc 2144341 aatgtataaa cccataatct cccaatggcc ggtcatcgta tctttgccgt ttgacgcttc 2144401 ttgcattttt ccataatagg caagcggatg ttctgttttt tctacacctt tgatatcttc 2144461 gataagacca aggccgagct ttgccatatt cggcatatgt aatccgttca tatgctcggc 2144521 aatatgaccg agcgtatgag cgccttcgtc attaaagtca gcggcatccg gcgcttcgcc 2144581 gattccgact gagtccatca caattaaaaa cacacgatta tatttgtatg caggcatctt 2144641 gaaagcctcc tttttttcta tacgtctatt gtatcgctaa gaggtctgac aactcaagta 2144701 taaaccgttt tcattcccgt tgacaatgta tttggaaata atgagaaact tcaatatttt 2144761 ctgtcgctct aaacaaaaaa gccgcagcca cctgcggcta tgctcgcgga tgaaactgct 2144821 tgtacacatc cttcagcctt gttttcgtca catgcgtata aatttgcgtc gtggatatat 2144881 ccgcatgacc gagcatttcc tgcaccgctc ttaaatctgc cccgttctca agcagatgcg 2144941 tcgcaaagga atgcctgagt gtatgcggag tcagctcttt cttaatgccg gcttccaatg 2145001 cgattttttt caggttcttc caaaatccct ggcggctgat ctgtttgccg tgatgattta 2145061 aaaagagggc gtcagataca ttatttttta acagttttcc cctggctttt gtcatatatt 2145121 cctcaatggc ggaagcagcg gcttcaccga ttggcacaat ccgttctttt cttcctttgc 2145181 cgaagcatcg gataaacccc atagataaat gaacatcagc cgttttcaat tcaatcattt 2145241 cactgactcg tatgcctgtc gcataaagca gctccagcat tgctttatcc cgatatccga 2145301 aagggctcgt cagcttaggc gtgtccaata accgctcgac ttcattgagc gcgagcacct 2145361 tcggaagcgc ccgttccgtc ttttgtgttt cgatatgaac ggaagggtcc ttatccgtta 2145421 ctttttccct gagcagaaat tgatgaaaag agcgaatgga tgccaaatgc cgcgccgatg 2145481 tcttgccgga tttccccgag tccttcaaat gctttaagta ttggataata tgtatgcggg 2145541 taacgtgatt ccaatctgta acatgaaggg tttctgttaa gtagagagaa tagcttttca 2145601 agtcacgttc ataggatacg atcgtatttt gagagagccc tctctctacc ataacgtagt 2145661 ggatgaaatc ctttatttga tctttcactc ttgatctact ccccgttttg gtaaaaaaag 2145721 atcaaccggt cgaaccatcc gcctttttca tcctgatcca tttcaacaac ttttacagcg 2145781 gagccttccg gtttatcata ccgatgatag ttttcatact cttgattcac ccatatcata 2145841 gcataataga acaaagcggt aaaaccggta aacaggatga aaactttcaa tgcatcgaca 2145901 gctgttttca ggaatcttcc catgtcctaa tcgatccttt ccctatggtt ccagttatat 2145961 aaaccatatg ccaaatcaga aaggttttat acatagaaac agcaaaaaac cctttcccca 2146021 tgagaaaagg ttcgcgctcg gcaccgtcta ttcagtttct tttccgttac agcggtggca 2146081 aatgccgtga aacgtcaatc tatgatcttt aatcttaaat ttccaatcac gttcaatgat 2146141 ttcttccacg tcttcaagca aatcttcttc aatttcatca acggctccgc actccatgca 2146201 caccaagtgg tgatgaaagt gagctgcgcc ctctttccga aggtcgtaac gggacacacc 2146261 gtctccaaag ttaattttat ctacgacttt taattcagtt aataattcaa gcgtacggta 2146321 tactgtagcg agaccgatct caggagattt ctcttttacg aggaggtata catcttctgc 2146381 gcttaaatgg tcttcttcgt tttcaagcag cactcttact gtcgcttcac gctgtggcgt 2146441 aagtttatag ctggatgagt gcagttgttt cttaatacga tcaatacggt tttccatgtc 2146501 tttccctcct acgccgcatt ccatgactca ttataacaaa atacgcgcag agttccaact 2146561 ataattatta taaactgata aataaaatgg ttttctttta ataatgattt taaaaaagtc 2146621 tagatgtaag cttttccatt aaaacaggag ataagtatgc ttcaaagaga gatgaaatca 2146681 gcgctaaaaa cagaatgacc agcagcacaa aggcataccg cccgaaccat tgaatcggcg 2146741 cgtcatgcag gcttcgtttc acgaacagct gtctgattaa ctttaaagaa aacgcaattg 2146801 cacatgtgcc cataatgaga taagccggaa tcagcagcac attttgcggc aaaacggaga 2146861 caaatgatag gaaaaacccg cttactccca tctgattgac taggaacccg acagtaaagc 2146921 cgacgacgat ccctttcaga aagatcataa tgaaaataat cggcatccca atgacggaaa 2146981 ttcccagtat ccacatcagg cctaaatact ttgcattatg aaagatactt tgcccaaaca 2147041 tatcagctga acttgcctgt tttccatccg aaagctgtcc aaaaaattga cttaagtagt 2147101 agtataaatc ttctttctgg ctgatggtca tactgttgac aataatcgcg ccaaagatga 2147161 cacccatgaa aaacagcact gacacaaata tataaagaga gagatgatct ttgacatgcc 2147221 tgagaaacat gtccttataa gagatttttc gcataccgtt tcctcccgcc cgctctagtg 2147281 atttgattta atagattgta tgaaagaaac agaaaaacat gccctttttc aaaaagaaac 2147341 aatagagatg aatgctaggc ggctttttgg ggcacaaaaa aatccttatc atcaactgct 2147401 gtatgatcat aaggattctt atgcttccgt ttattcaaaa tctctttttt gctttttgtc 2147461 attcttccat gtgtgctgaa agatggtgtg ctgcctcttg ataataagac gtcacgtccg 2147521 ccgtttctca atcgatgccc ccgcttcttt ttcgcttggc tttttgccat gtgatcactc 2147581 ccttttttat tttcatagta atgataacaa aattgaacaa tgataagaaa aaaacagcac 2147641 ctgctacgac aggtgctgtt tagctacatt tatttcactg ctgtaagagc tgcatgctcg 2147701 acagctgctg ctaccgcatg atggactttt gaatcaagcg gctgagggac aacatcacct 2147761 tgtttagtgc aagctgcgat ggcctctgct gctgcgacaa gcatatcatg attaatctcc 2147821 gtgctttttg cgttaagcgc tcctctaaaa atccctggaa aaccgagtac attattaaca 2147881 gaacgcccgt cagctgcata tgcggcgcca gcctgcagtg cggcctccgg ctcaatttcc 2147941 ggcttcggat tcgataaagc cagaatcact tgaccagaac gtacaaatgc cggttttatt 2148001 aaacccggaa cgcccgttgt agcaatgaca atatcacatg tttccataag ctcctcaata 2148061 ctggaaactg cctgtccgcc gtattgttcg agacggttca ttgctgactc tgatttgtct 2148121 gttccgtata cagcattcac accataagcc atgaacatcc ggcagatggc cacgcctgct 2148181 gcgccaaggc cgatttgccc cactttcgct tccttcaggt caacccccgc actcctgcat 2148241 gccgaaatgg cagctgccag cgtcactaca gctgtaccat gctggtcatc gtgcataaca 2148301 gggatgttca gctcctcttt taggcgatcc tcgatttcaa aacaatgcgg cgaaccgata 2148361 tcctcaagaa ggatgccgct aaagcccgga gaaatatgtt ttactgtttt gatgatttct 2148421 tcaggatcac tcgtatcaag cagtatcgga atgccgctaa tacccgccag ctgatcaaat 2148481 aaagcagcct ttccttccat gacaggcatg ccagccacag agccgatatt cccaaggcct 2148541 aaaattgcgg ttccatccgt tacaattgca acagaattgc tgatcgttgt ataaatagaa 2148601 gctttttcag gttctttttc gatcagtcgg cacacgtccg caacacctgg tgtgtagaca 2148661 cgtcccagct ctgccagtga acggatcggc attttgcttt tcatttggat ttttccgcct 2148721 tcatgtgcgg acaggacttc atcagatacg gtgtgaagcc tgatcccttc tccgagggcc 2148781 tgtacagccg cgatcacttc ctgaagctgt tcttcattct ccacttgaac ggtaatattc 2148841 cgcattgtgt aattgggtcc gacttttacc gtctccactt caccaatatc cccgcccaga 2148901 aggccgatgg ccgtagccac ccttccaaga tttccgggaa ccgaaggcgt ttcgatcatc 2148961 agtgtccgaa tcatgtgttt cgctatcatt cagtgatcct cccctattag cctagttttt 2149021 cggctttaac tgtattgttt ttcgtatacc atataaattt tcctgtataa ccatagataa 2149081 ttgcaagacc tattgctaca aaactgagcc acataaacgg cagataagag aaggtagaaa 2149141 cacctaaaat accagccatg taaatcccat tatcagacca aggaaccatc cccgaagtca 2149201 atgttccccc gacctctgag ttacgtgata acactcttct gtccagatgt aagcgatcat 2149261 agctgtcttc cataattttc ggagtcaaaa taagagatac atacatcgca cagccgaaga 2149321 tgtttgctaa aaacgctacg atcagtgtag acaatgtgac attgccggct gaagttaatt 2149381 tcttttcaaa cgttgaaaca atgactttta acacgccgag tttctcaagc agaccgccaa 2149441 aaccaaggcc aaagatgatg acgacgagag aatcaagcat accgacaatt ccaccgcggt 2149501 ttaacaagcc gttcaaaaat tcaacatccg ttttaataga gaagccgttg tacgcagttg 2149561 caatcgcatg ggcaatatcc attccttgga aaacaacagc ccagattgca ccgagtaaag 2149621 cgccaattac gataactggc atagatggct ttttcatcgc caataagact atgacgagaa 2149681 ctgccgggat cagcatccaa atatgaatgt caaacgtgtt ttgcaaagat gattttaaga 2149741 attcaacttt atcaagatca atatttttcc cgccgtacat aaatccaaca actgtaaaga 2149801 gtatagctgt aatgacataa gcaggtattg ataaataaag cattgctctc acgtgagcca 2149861 atacatcgac ttttgatagt gaagaagcta gaactgtact gtcagacagc ggagacagct 2149921 tgtccccaaa ataagcacct gaaagaatag ctcccgctac tagaggaagc ggaatgccta 2149981 acccctctcc aattgcgatc atggcaatgc cggcagttcc gactgttccc catgacgttc 2150041 ctgttgccac agacataatg gaacaaataa ttaacgttgc cagtaaaaag atacttgggt 2150101 gaataaattc cagtccgtaa taaatcaaag tcggcacaac gcctccggca atccatgttc 2150161 cgatgagcgc cccaactgaa acgagaatca gtacggcttc aaggccattt gatatcccat 2150221 gtacaatcgc attttgtaaa tctttataag aataaccgag tctaatacct aaaagcattg 2150281 caataaacca tgaaacaaaa agcgccagct gtatcggcaa gtcgagaaag actgtaaacg 2150341 atagaacaag tgctaaaaat actcctagta caataataat ttcaaatagt gttggcaatc 2150401 ttacatcctt caaaagaagt cccccttcat gtaaaagcta aaacgctttc aatatatagt 2150461 gcaacacgta tactatactt cctcatccct atgttgtaaa cagcttattc atccgactat 2150521 tcggagatga ataagctgta ttttatacaa attttatttt tctaatagtt ctttccctgc 2150581 gatacctggt ttggtcatct catatgggtt taaaataata tccaattctt cttcagtcag 2150641 cacatcatgc tgcagacaaa gatcccggac agattgccct gtcataattg cttccctggc 2150701 aattctagct gccgcttcat acccaagatg cggattgaca gctgtgatca cgcctgcgct 2150761 tttttctacg tattgcttca tacgcttttc gttggcttca atgcctttta agcagttgtc 2150821 agtgaacgaa cggaagccgt tgttcatgat gctgatggat tgaagcaaat taaagacaag 2150881 cacgggctcc atgacgttca actcaagctg gccggcttct gaagcaaggc agattgtatt 2150941 gtcatttccg ataacctgga acgcaatttg gttgatcagc tccgccataa ccggattgac 2151001 tttccccggc ataatagatg aacccggctg acgtgcaggc agagaaattt ccgcaagtcc 2151061 ggcgcgcggt cccgacgcca ttaagcgcag gtcgtttgcg atcttcgaca tgttcatcat 2151121 gcagactttt aatgaagctg atacctctgt ataggcatct gtattttgtg tcgcatcaac 2151181 aagatgatca gcgccgacaa gaggaagccc gctaatatca gcaaggtgct ttactacctg 2151241 tttgatatat tcaggatcag cgttcagccc tgtaccaaca gcagttgcgc ccatgttgac 2151301 ttcatacagg tgctggcgcg attgcttgat tcgtttgata tcacgctcga gaacacggct 2151361 gtaagcttcg aattcctggc caagacggat cggaaccgca tcttgaaggt gtgtccggcc 2151421 cattttaata acagagtcaa actcctgtgc tttttgctta aacacactat gcatatcttc 2151481 cattgttttc agcagttttt ctaagagctt caatgtggaa atatggatag cagtcgggaa 2151541 cacatcgttc gtagactgtg acatgttcac atgtgtgttt ggacttaaat ggatataatc 2151601 tcccttttta tgtcccatga tttcaagcgc ccggtttccg ataacctcat tcgcgttcat 2151661 gttcatagaa gttccggcac cgccctgaat cggatcgacg ataaactgat cgtgccactt 2151721 gccttccaga atctcgtcag cggcttgtac gatagcttgg ccaattcctt catacagccg 2151781 tttcacgtcc atgttggcaa gagccgcagc ttttttcaca atcgccagtg cgttaatcat 2151841 ttcctcatgg attttgtatc ctgtgatcgg aaaattttca gaagcacgga gcgtctgaat 2151901 tccgtaataa acatctgctt caatttgttt ttccccaagg aagtcttttt ccacgcgata 2151961 ttctttttgg ccgtttaaca taatctttaa ccttctttct ctttgctggt tatcgttttt 2152021 acattttaca ggacaacgtc atcagctatc ggcgtttcca taattctctt gacgacagga 2152081 agatccgaag actgacctag cgcccacatc aattttggca caattgcttc tgtgttcata 2152141 tttcttgatc ggataattaa gtcttggttg actctgcggc caacctcgta aatgctcatg 2152201 tcttcgcctt cttcaagaca ttgagtcgta atgacgacga caatgccgct ttcgatcagt 2152261 tcattcactt ttgacaaaat gtctctgcct tcaaacggca ctcctccgct gccataactc 2152321 tcaatgacaa ttcctttgta catgcttttc agggcatcaa acatttcggg ctttaagcct 2152381 ggatgcagct tcagcagaca tacatctgtg catagtgaag tgtcaactgt gaaggtgtcg 2152441 ttctcaggtt ccgttacttg tttgttgtat tcgatcccgt cttcattgat aaaagcgata 2152501 tatgggtaat tgatgctttc aaatgcgtcg tagcttttcg ttcttaattt gatcgcacgc 2152561 gttccctgaa tgactctgcc gtcaaacaca acataaacgc cgcccacgcc ttcacaggca 2152621 aatcgaatgg catctgtaat attttttttg gcatcggttt tttggaacgt gatcggaatc 2152681 tgcgagccgg tgatgacaat cggctttttg gcatgctgca gcatatacga tagtgcggca 2152741 gatgtatagg ccattgtatc tgtaccgtga gtaataacaa acccgtcata ggcatcataa 2152801 ttttccttaa cggcttctgc tatttccacc cagtattcag gctgcatatt ggtgctgtct 2152861 atattcataa gcgactgagt ttccattgtg taatcgttat caagttttga tacgtaactt 2152921 aataattcat cagccttgac tccgggagcc agcccatttt ccccttcaac tgaagcaatc 2152981 gttcccccag ttgtcaacat caataatttt ttcataccat gcacctcttc actgtatcta 2153041 aagatgggtt gcgagaaggt attcgctttt cgcatacttt taatgcaatt atagacacgg 2153101 aaaataaaat acgcaagaca ttattattca attcgcgtac acttcctaat acctatatga 2153161 tataatcagc tcaaggtgaa aaaggagcgg aagttcatga atctagatcg tttaactgaa 2153221 ttgagaaaaa agaaaaattg gtcgcttcaa tatacagctg accttctcgg tatcgcaaaa 2153281 agcacatatg ccggctacga gtcaggctac cgacggcctt cacttgaagc gcttgccatg 2153341 ctggctgacc tctttgacac aacctgcgat gaacttttag gccgcgagaa acaaaagcag 2153401 actgctcctc aggccataga attggccacg tggagcagcc tcgactttac catttctgtt 2153461 gatggccagc cgctgagtga agatgaaatc atccagctga ttacctttat acgcacaaaa 2153521 agaaaagtac aggaggaact gagttaatct ttagctcacg gtttaatttt accgtaggtt 2153581 cctcctcctc cggctttcaa ttccagtttt ccggatctcg cttttacgat aagcgccgcg 2153641 gttttcggcg ggacaacgcg agccaaatct tcttctgcag cctcatgaag aacagccatt 2153701 tctgttccga aggctttttt tagtttgtcc agcgttttcg ggcctacacc cggaacaaat 2153761 tgcagcggga tctgatgtac atatcgcgga cgcgggacgc gaacttcaag ctgatcactc 2153821 aattcacgca atctatcgct gactcccttg gtaaatctgg cttttccgca attcgcgcac 2153881 gctgtttccc cgcttacagc aggctctccg cacgcttcgc aagccgtctg ataatatttc 2153941 cccaataacg ggtccaagcc ataatttgcg ataattttcc tgtcatcttg tccctttaat 2154001 gcaagagcaa attcagtaaa atcagctgac tgcacatata attcattata ttctctgccg 2154061 attttcccca acgaatgcgc atcagaattt gttaaaaaag gatacggatt caattgcgat 2154121 acgtgtgatg ccatgtctgt atcacagctt aatccaagct ccaccgcgtc tatcatagat 2154181 ggatcaaaaa cctcagttaa gcttgattta accccttttc catataagct tttatgcggc 2154241 gtaaagatat gggcggggat aaacaggccg cccatatcct gcactttttt ttgcaggttt 2154301 aagcccgttt cataaatccg ctgcgagctt aaatgaatat ttttcagccg ggctgacagc 2154361 cagtttgaaa actgtttcat atcagccagc gtcggcataa atacgagcac atggatcggt 2154421 ccgctgcagg cttcatcata aatctccagc tcgctcccca ataaaagagt cgtgctgcga 2154481 taacggattc ctcccccgtc aagctcgcga tattttccag atgaaatgcc ttcctcaagc 2154541 tctagaatga cttccggaga atgacagtcg ataatgccga ggagttcaat tcctttatgt 2154601 tcactggctt caaccaaaat tctgtccagc gttaatgttt tggcgcctgt tattttgaca 2154661 gcccttcctg taaaggtccg gccgatatga atgtgcaaat ccgcgtaaat ctttttcatt 2154721 tttgtgcttg gagcgcttct ttcagctgaa gatactgaat cgcgtaggct gttttagcat 2154781 catatacttc acgcgattca accagcttta gcgcatcttc aagcgtcacc tccatcactt 2154841 caacaaactc gtcctcatca agctcccgtt tttcttcaag cacagaaagc tcctcagcaa 2154901 gaaaaacgtg aacgatttca tctgcaaatc cgggtgatgt ataaaacgca gttatttttg 2154961 tcagtttttt tgctgtataa ccggtttcct cttcaagttc ccgaagtgcc gtatactccg 2155021 gctcctcacc tttttcaagc ttaccggccg gaatttcaac gatcgtccgc tcaagcggct 2155081 tacggaattg tttgaccatg atgattttcc cttcatctgt gacggctagt accgctacag 2155141 ctccagggtg tttcacaatt tcacgtttac tggctttgcc gtttggcagc tctacatcct 2155201 cgacataaag atcaatgact ttacccgaaa aaatctgttc tttggcaatt gttttttctt 2155261 ctaatgattt catttcttca tctcccgttc tgtctctata tgatgcccca tacattttat 2155321 catactagag caaaaggggg cttcttcgtg aaagtgcacc gcatgccaaa aggtgttgtc 2155381 ttagtcggaa aagcatggga aattcgagcg aagttaaaag agtatggacg cacatttcaa 2155441 tatgtgaaag attggatctc aaagccataa aagttgaaac tttagctcct ttatattacg 2155501 gtcaatacaa agcctaaaaa aggagtgtgc acatgagaaa gcgcaaattg ggtacatctg 2155561 atttagacat tagcgaagtc ggactcggct gtatgtctct tggaactgaa aaaaacaaag 2155621 cattgtccat tctggatgaa gcgatcgagc ttggcatcaa ctatttggac acagcggatt 2155681 tgtatgaccg gggacgcaat gaagaaattg tcggtgatgc gatccaaaac agacgccatg 2155741 atattattct ggcaacaaaa gcgggaaacc gttgggatga cggaagcgag ggctggtatt 2155801 gggacccttc aaaagcttac ataaaagagg cggtaaaaaa gagccttaca cgtctgaaaa 2155861 cagattatat cgacctttat cagctccacg gcggcacgat agaggacaac attgatgaaa 2155921 cgattgaagc gtttgaggaa ttaaaacaag aaggtgtcat ccgctactac ggcatttctt 2155981 ccatccgccc gaatgtgatt aaagaatatg taaaaaaatc aaacatcgtc agcattatga 2156041 tgcaattcag cctgtttgac agacgccctg aggaatggct cccgctttta gaggaacatc 2156101 aaatcagcgt agtcgccaga ggtcctgttg ccaaagggct cttaactgaa aaaccgcttg 2156161 atcaagcttc agaaagtatg aaacaaaacg ggtacttgtc ctattcattc gaggaactga 2156221 caaatgcccg taaggcaatg gaggaagtgg ctcccgatct ttccatgaca gaaaagtcgc 2156281 tgcagtatct gctagcacag ccggctgtcg cttcagtgat tacaggcgcc agtaagattg 2156341 agcagttacg ggaaaatatt caggcagcaa atgcacggcg tttaaccgaa gaggaaatca 2156401 aagcgctcca atctcatacg aaacaagaca tttacaaagc tcatcgctca tagcagaaaa 2156461 accagcacct gtacgggtgc tggtttattt atattgatgc caatccattt ggctttcatt 2156521 taggagttct tcaaagctct tatttttttc gatctctttt ttctttctaa tctgttctgc 2156581 tttttctctt ttctgcctct tttcatcctc ttccttcaat tggctcttca tctccataag 2156641 ctttgctttg atatcggatt gaaggccgtc ttttagctgg tgtttgtcaa tggatttttg 2156701 ttttttcatg cagacttccc ccatgttttg ttttgaagcc agtttatcac ggagcatata 2156761 aactgaacaa gcagactctc ttctgatcac tttctcagcg tagcagtgtt taggtataat 2156821 gatcttaaac acgaattgcc tatatatttc gttgaaaggt gctgtgactt ttgaagaaaa 2156881 tccttttggc cattggcgcg ctcgtaacag ctgtcatcgc aatcggaatt gttttttcac 2156941 atatgattct attcatcaag aaaaaaacgg atgaagacat tatcaaaaga gagacagaca 2157001 acggacatga tgtgtttgaa tcatttgaac aaatggagaa aaccgctttt gtgataccct 2157061 ccgcttacgg gtacgacata aaaggatacc atgtcgcacc gcatgacaca ccaaatacca 2157121 tcatcatctg ccacggggtg acgatgaatg tactgaattc tcttaagtat atgcatttat 2157181 ttctagatct cggctggaat gtgctcattt atgaccatcg ccggcatggc caaagcggcg 2157241 gaaagacgac cagctacggg ttttacgaaa aggatgatct caataaggtt gtcagcttgc 2157301 tcaaaaacaa aacaaatcat cgcggattga tcggaattca tggtgagtcg atgggggccg 2157361 tgaccgccct gctttatgct ggtgcacact gcagcgatgg cgctgatttt tatattgccg 2157421 attgtccgtt cgcatgtttt gatgaacagc ttgcctatcg gctgagagcg gaatacaggc 2157481 tcccgtcttg gcccctgctt cctatcgccg acttcttttt gaagctgagg ggaggctatc 2157541 gcgcacgtga agtatctccg cttgctgtca ttgataaaat tgaaaagccg gtcctcttta 2157601 ttcacagtaa ggatgatgac tacattcctg tttcttcaac cgagcggctt tatgaaaaga 2157661 aacgcggtcc gaaagcgctg tacattgccg agaacggtga acacgccatg tcatatacca 2157721 aaaatcggca tacgtaccga aaaacagtgc aggagttttt agacaacatg aatgattcaa 2157781 cagaataaaa aagcgaaagg cctcttcggc tctttcgctt ttttatgtta cagaacgtcg 2157841 gtaatgccat ccatattttc tctgatccat tcaatcgcaa gatctatcgt tgtaaactcc 2157901 tgcgtctcga aggtcatttc atcctgcaat agccagacat ctttcttgat ggactctgct 2157961 cctccgattg accagtgaag caaggtataa ggatggtttt gattcaggaa ggatacccac 2158021 gttttatttt gtgctgtgtt cttcattgcc ttcagctttt gttccacgtt tcgcgtctcc 2158081 tactttacta atatgctcat tctggggctg agcatttcag ccgggctttt cagcgccaat 2158141 gttttggctt tttcattgta atcgatcgtc atttgatcgt caaaaaacac tttttgcgac 2158201 gattggatat acagcggaat gccgttcgtt tccagctgct cgcactgtcc cgttaattct 2158261 tctgccagcc agattgtcgg gacaccgctt accgcgcagc cgcatccttc tgcatcgtaa 2158321 cgaagctggg ctttttttcc cgggttggcg tcaaacgcct gctgcagtgc ctgttttgct 2158381 gcatctgtca catgtatgtt cataaggtga aacccccgtt ttcatcattt tcgctattgt 2158441 agcatacaat actgccattc gcattgtttc tgcctttttt ccaccgcttc gcattttctt 2158501 ctgcagtctt gatccactca tctttccctt gtatatactg attgatgctg tcagggtgct 2158561 gggccgccag ctgttttttg agaacggcgt attctttcgc tatgtttgga tgagctctga 2158621 gataatctct gaataacaga tgcctttcaa tagcagggtt tccctgttcg tacatatgga 2158681 catgatgagt gcgtttattt ccgccctttt ggaaataacg cctgcccgct ataccgttct 2158741 caccttttgg tgtatagccg ttggccttca tttgttcatc aaattggctc acggcttcaa 2158801 tgcttctgac ttcaattaac atatcaatga ttggcttcgc tgccatgtta ggtattgatg 2158861 tgcttccgat gtgatgaata gcgataatct ccggcccgaa cacaagtttc agccgttctt 2158921 tttcttcatc gaaacattct gcccattttt cgttgtagag aatgatctca acttttcttt 2158981 tcggatacaa atgaaagacc gacagcaata gaccctgcgc tgctttgacg gtttctgcct 2159041 tttggaatcc ggcctgtgta tagagtgaca cagccggggt attgttctcg gctgtgacta 2159101 cttcgatttt ctcagcgtct tcattatgat caatgacaaa ttgcagaagc gctcgtccaa 2159161 ttccttttct gaaaccgtca ggatgcacaa caagcctgca aatggtgaga taatgcatgt 2159221 ttttctcata tgaaatgaca ccgatcagct tgccgttttt ccgatatccc gcaaaccgtt 2159281 catgggatgc ttgaatatcc tttaccttct cttgtaaagc gggaataccg tcaaaaccga 2159341 taatctctgt ttcctttatg taggcgggga tctgtacggc taaaatctca cgcgctatag 2159401 tggcttcctt atgctggaga aattcaatca ttcgtgttct cctgaaacag ccgctgtctg 2159461 tcgacttttg cgacgcggac tgcatacgac tcgtaccaaa cgcttcttcc tttttctttt 2159521 gctgcttgat gttcagtgtg atgcctccaa tggttaattg cgtccatact gtcccaatag 2159581 gaaactgtga tgccccttcc atccgcttca cgtacgcttt ccacgcctaa aaatccaggc 2159641 tgatccgccg caagtgatac catccgctcc gctgtttctc catatcctgt gtcattttcg 2159701 cttttgacag aagaaaaaat gactgcatag taaggaggct caggtgtttt tgataaaaaa 2159761 tccatcatat ttccccctca tatgtttttg acaaatagta ccctgtcttg gcccgggcca 2159821 tcatagtttg caaacactga gatgccattt accgttttgg tgcccttttc aatatcaaac 2159881 cccaattttg tgtgatatgc gattgatacc ttattcacag gtgaagtgac acacttcacc 2159941 cgggtgcagc ccctttgttt tactgtttcg ataaatacat catacaattg tttcccaatt 2160001 tgcatttttc tgaaatccgg atgcacaccg gaaaaatgaa tgtacgccgt ttcaggatcg 2160061 gattgcgatt gaaatccgat taaaaatccc gtcatgctgt tatgttcgga tgtaataaag 2160121 cttgtgtcct gaaaatgctc aaaaaatagt ctcggcaatt tttctttcag ctgtctgccg 2160181 ccccaccatt cattcagtac agacgttacc atttcataat ctgaagacgt gattgttcga 2160241 atatccatta cgatttgatc tccctccgtc tggcaaaacg aatgtcagct ctttttctca 2160301 caatataaaa attatatttt gcctggctgg aattgtaaat gccttctttc ctgtatcata 2160361 cgtttccaga ctgccgaggg aacaatgttt gatcatttta cgcctatttc tcccccaaac 2160421 aggaggagag actttacagc acaatatcaa gcacttgatc aagtttcagc ttataaagct 2160481 gatcctcgtc tccttttatc catactgctt tttcaaactc ttcataccgg cagattttcc 2160541 cggtgcagca gacaatctca ccgtcctgaa agcagctgac agtgatatcc tgagcaaact 2160601 ccatcgcggc gcaaagcgtt tgattcatct cttccagctt atcggggtca aggatcggct 2160661 tttgcagctt ctgtttaagt cgctttctct ccagcaggct ttgcttatgt tccggcagaa 2160721 acatcctgct cccttcccac agcaggttgc ccctttttaa atggtcgttc atttataatg 2160781 cccccctatt ttagccgcac gttcaaatgc ctggcctgcc gctgtcagtg acgccgccct 2160841 gatgattgct gtatcgccga atcgattttt aatgccatcc atcacatagc ctaggctcat 2160901 tttctttgca taatcctgaa ataaattgag ctgccatatg tcatcagatg agagctgaga 2160961 cagattgaca ccgaggcggc ggacgggttt cccgtcccaa aatgtaagaa acagccgtcg 2161021 tacagcctca tatacatcct gcgtagaatt agtcggctct gccagcttca cttgccggtt 2161081 gaagcccgtc ggccaatcaa aatcagcacc ccggcagctc actgacactg tctgccccat 2161141 gaccccggcg tttcggcttc gcctgcacac ctcttcactc agctcaagca atacgacctt 2161201 gatttctttg tcaaagtgtt cgtagtctct cgggagagtc attccatgac ctatcgcctt 2161261 ttgcccgtcc agagacgaag ttgacacagg ggaatagtcg attccgtttg ccgtcatcca 2161321 cagcacgtgg ccgttaatgc cccatttctt ttttaaaaga tcgagcggaa aagccgcgag 2161381 cccgccgatc gtgctgatgc ccattcgatt taaatgatgc ttcatgcggc tcccgacgcc 2161441 aaacatgctg cccaccggga gcggccacat ttcggttttc atattttctt tcgttaaggt 2161501 aaaaataccg ttcttattct ttttggcaaa attgtcacac gcaattttgg ccagcgcttt 2161561 gttagggccg attccgaccc gtgcataaac gccgatctcc cgcatgattc tgccctgaat 2161621 gcttttcgcg atctccatcg gcgtcccaaa cagcttctgg ctgcctgtaa tgtccatgaa 2161681 ctgttcatcg atggaatacg gctccacaag gtctgtatac tcctcgagaa tggccgtaat 2161741 ttgcagtgat acatcaatat accgctgcat acgcggccgg agcacaacag cctcaggaca 2161801 cttttcctgc gcctcccaca gccgtgaagc attcaccaca cccttttgtt tcgccagcgg 2161861 gcaggcagcc aatacgactc cgcccctttt ttcagggtca cccgaaacaa tgacgggcct 2161921 atttttcaaa tgtggatttt ccgctttctc tacagatgca taaaacgatt gcatgtcaac 2161981 gagaaaaatc actttttctt tcatcataca cacctctaaa aagaacttat gttcgctttt 2162041 cattatatgc gaaagtatgt tcgttttata ctggtaaatg attcttgtct gacagaaaat 2162101 atgatccaag ggtttgagag aagaaaaaca tttagtagaa taaaagcgaa gcataaggat 2162161 aggagagtca tgatggagaa atttgtcgaa aaaatgctgg gacaggcatt gcggcaatac 2162221 ggcagaaacg ttgctataga tccgttaagc ccgtatgaaa aacaaagcct gaaagcggct 2162281 ctacaagaga gacggaatga agaaccagat gaggatttgc atgcgcatat agaagatatc 2162341 atttatgact atgtcacaaa ccaaggcctg ttctcttaaa cgcatgactg tcagttcttt 2162401 cagccgctga tgcggcttcc ctttgaaaac accgcctgaa acaaataaac agtctcaggc 2162461 ttacagaaaa aaagcaggat tttctcacgc tccatagatt catatggcct ggcgtaaaat 2162521 tcccctcaat gctcgcgcaa aacggaataa gctgtccatg atcacgcgta tacacttttt 2162581 cgaagagatg tgctctcttg ttctgtcatg cggtccatgc cggttttcag cgtacatctt 2162641 gatctcatag ccggtttcac tgccgatatg atccacgttc tggcggctta aactaacaca 2162701 ccctcactga ccaatcgctt tgcttttcat cggacatccc gtcattttcc ttctttcaag 2162761 atgtaaactc cgtcagccac acgcatcctc aacgcatagt atattgccat ccatacaatc 2162821 aggcatacta catgtcaata acgaaatatt ttgaacgatc tattggagaa ggaaattttt 2162881 tcatatatga tagagaaaga tcatacatac aggagagaat ataattcatg aagaaatgga 2162941 aagatatcca cccgatcagc tggacaatta taatcggaac cattttcggc agaatggcaa 2163001 catcgatgag cattcctttt ttagcgattt atttgacagc cgtccaaggc gcatcagctt 2163061 cctatgcagg gctggtcatc gccgcgagct catcagtcgg catcctcgca agcttttacg 2163121 gcggatatat ctcagataaa ttcggcagaa aaaacatgat gcttgtatcg attttcggat 2163181 ggatgctggt atttgcaggc tttgcggcag catctaatct ctgggtgttt tttgtagtaa 2163241 acgcattaaa cggtctttgc aaatcactgt ttgagcccgc ttcaaaggcc ttgttgtctg 2163301 atatgacaga agaaaaaacg agactgctag tttttaattt acgctatgcg gctattaata 2163361 tcggcgttgt cttcggacct gtgcttggcc tatatttcgg ctcatcgcaa tcgactacgc 2163421 cctttttggt gcctgcagtc atttacggac tatacggaat tgtgcttgcc ctccaattta 2163481 aaaaacatcc atccttatca gcaccagccc agtcccgaaa tatgagcgtg cgggaagcgt 2163541 ttatggtcac gcaaaaggat tatcttttta ccattgcttt ggtcggcatt acgctatgca 2163601 ccttcggcta ctcacaattc agttccacat tccctcagta tatggcgcag aaccccttga 2163661 tcggcaatgg aacgaagctg tatgggctga tgctgacatt aaacgcaatc gttgtgttgg 2163721 cgacgcaatt tcccattgtc cattttgcaa aacggttttc gccgctttgt tctctgatgc 2163781 tcggtaatgt gatggttagc atcagcatgg ccattttcac cgtatcacac ggtgttccat 2163841 caattgtgat gattgtcatc acatttacaa tcggcgaagt gcttttattc tctatgatgg 2163901 atttgtatgt agaccagatt gcaaaaccag gattaaaagg cacttatttc ggggcaatcg 2163961 gtttttcaca gctcggaaac gtcatcggcc cttgggtcgg ggggatatgt atagacctgt 2164021 ttggcgctgg ccggccgatt tatatttttt ctgtcctgag cggcattacc ctgctcggcc 2164081 tgccattttt agcgttcgcc tatcggcaaa tgaaaatgga gaccacaaaa caccgttccc 2164141 gtctggaaaa gccgctttaa ataaaaaacg gaagagaatg aatctctccc gcaaacatga 2164201 ggtgaagaac atgaatatag gtgatgtgat gtttcagctg tttgtattta ttatatttgc 2164261 cgctgtcgtc tttgcggctg ttacaggctt caagtatgcg aaaaaccgaa aagcgcagct 2164321 ggatcgcatt gagaaaaagc tgaacagcct gtccgaagat cacgattaac agcttggggc 2164381 aacgagctct accttaatcc ggtctggatc ctcacaaaag actgcataat gcccgtctcc 2164441 tccggcaaaa ggatgcctgt ctcggtacaa cacacgatag ccttttgccg tcaatttttc 2164501 agtcatctga tcgacttgaa gcttggattc agcatgaaat gcgagatggt tcagaccgac 2164561 tcggcatcta tggtattccg gctctagaaa tggctctttc gcctgcacaa tcactaggta 2164621 aaaacgatct ttcttccagc tgatgcctga gctccatttt tgatactctt tataaccaag 2164681 ttcttttaag aaccagcccc aaaaccgcct agacgcctcc aaatcagaga catacagttc 2164741 aatatgatgc acatttcata ccctccttac caacacttcc tcgaccttat gcccgtctcc 2164801 cttacgcaaa atgagatctg acctgaattt agttggcaaa atattttcat ataaattcgg 2164861 ccggttgaca ctctcccaaa tcgaggctgc catctcgtca gcctcctgat cggacaagtc 2164921 tttaaattta tgaaaatatg aatcaggatt ttgaaaagct gtttcccgaa gcaggcgaaa 2164981 acgctctaaa taccaagtga aaatccggct ttcctccgca tccacataaa tcgaaaaatc 2165041 aaagaaatcg gaaacaaaaa tacgcgggtt ttcccggtca tcctccaagg tgggcgactg 2165101 aagaacatta atgccttcaa taatcacaat atccgcctgt tctacaacct cgaacacacc 2165161 ttcctcgcgg tcataggtta gatgggaata caccggggcc tttacgctgt cctttcctga 2165221 ttttaagtca ttcaaaaatt cgagcagcgc ctttacatca tagctttcag gaaatccttt 2165281 tcttgacatc atatttttct ttttcagctc ggcagtagga aataaaaaac catctgtcgt 2165341 gataaggctc acttttggac ggtcaggcaa acgcgaaagc agcttctgca agatccgcgc 2165401 cgtcgtgctt tttccgactg cgacactgcc ggcaatgccg ataataaacg gaattttggc 2165461 tgaatgtggg tgcttcaaaa aaacattgac atgcttattg cgttcagccg cagacttgac 2165521 atgtaaatga agcaagcgaa caagcggaat atagatcgtc tccacttctt caacagatag 2165581 ataatcattc aatccttcca cagcttttgc ctcttcttca gatacagcaa tcgacaaatg 2165641 ccccccaaaa ccagaccaag actcccgatt gtgctgtgta tataaagtat gtaggttaag 2165701 ttctttattt ttcactgttt acacctgact ctctgtaggt taaaaccctt acaaagattg 2165761 taacggaaaa ccttttcact gtctgcttat ttttcatttc gtttttttag caaatcagca 2165821 ccgattcggt tatacgcagc catttcatct tttggaacca tgcttcctcc cgttccccag 2165881 acgacatgta cggcatgttc catcttatat ttctgagcat agcgccttcc ctcttctgtc 2165941 gaaaaaagct gaaccggccc gaacatgcca gcaagagcag agggctctaa atatttatct 2166001 tcagatacag ccagcatatg aagcaaagta taaagcgtat tgtcctctac cgtataacag 2166061 ccgctcagaa gcggttcaat cagcttgccg acaaatcctg acggcctccc tacggcaagt 2166121 ccgtcagcag ccgtctgatt atccaggccg atatcctgga cggagatctt ctcgtgaagt 2166181 cctgaataaa gccctaacag catacaaggt gaatgagttg gttctgcgaa aaacacatga 2166241 acatcatctc cgtataaaag cttcagccca aatgctacac cgcccggtcc tccgccgact 2166301 ccgcacggca gatacacaaa caagggcgtc tcaagacttg gctttatatt catacagtca 2166361 agctgtgttt ttaatcggct tgcagcaaca gcatatccta agaacagctg acgagaatgt 2166421 tcatcatcaa taaaataaca gaatggatct tgttccgcct gccgtctccc ttcgttcacc 2166481 gcttcactgt aatctgtttc gtactccata acagtgactc ccttttggcg gaggagatcc 2166541 tttttccact gcttagcatc ggcggacata tgcactgtca cgcgaaaccc gagtgccgcg 2166601 ccgatgatgc cgatgcttaa acctagattt cctgtcgaac cgacagcaat cgaatagcgg 2166661 gagaaaaacc cggtaaaccg ctcttcctgt aagatgcggt aatcatcggt ttcctgaagc 2166721 attccttctt gaagcgcgag attttcagca tactttaaca cttcataaat cccgcccctc 2166781 gctttaatcg atcctgaaat cggaagctca tggtcgcact ttaaaagcca tcttccggga 2166841 aatggctgct gatatgccgc ttccagcttt cccttcatat gctgcacctc aaaaagcgga 2166901 gactcgatga ttcctttagc gcctttcgtc tcaggaaaca cctcggcaat gtaaggtgca 2166961 aaccgctgca ttcttttttc cgcttccgct atctcggttg cccactcatc tgcacggggt 2167021 aatggcccct ctttcttgcc tgaatttgcc cagaatacag gctctgcatc aatcagtttc 2167081 tgaataaacg gatctttaag cagagcatga aggacttctg aatgaactga cattcaacaa 2167141 tctctccctt ccactatcaa aaactgcccc gtgagaaaca agccactcca ccacaggcag 2167201 ttctatcatt attttttcat gagcgcgcgt cctgccagct tttctacaag agctggaaac 2167261 agctgataca gcttagtgcc ggcattcatt aaacgcggaa gattgatctc ccgctttttc 2167321 gtaaaaattg cagctgtaat ttgagctgcc acgtcatcag gatcaagcat ccagcggccg 2167381 acatttttgg cgtagtcccc gcctttatca gcaatggaaa aaaagtccgt ctgaatcggg 2167441 cccgggttga ctgttgtcac ataaatgccg gttcccgaaa gctccatccg caaagcgttt 2167501 gagtaaccta acacggcatg tttggtcgcg gaatacaggc tagacttcgg tgtggcgatt 2167561 ttccccgctt gagaggcgat attgatgata tgtccctttt tttgctcaag catttgcgga 2167621 agcaccgctt ttgtacaggc gatcaggccg aagacattca catcaaacat cgctttcatg 2167681 tcatccaatg tagagtctaa aaccgtttca aatataccga agcctgcatt gttaatcagt 2167741 acatcaatcg agccgatctg atcgcggacc cgggcgatat cctctaggcg gccgacatcc 2167801 agaggaaaaa tctcacactg tccgctccat tcctcggtta ttttcctttt gatttctatc 2167861 aaacgatcct cgcgtctagc cgacagcagg acatgggctc cttcagccgc gcataagtat 2167921 gcgattcttt ctccaagccc tcctgaagcg ccggttatcc aaatcctttt tcccgctata 2167981 tgtttcaccc atttcacctc ttcattgttt taaagtatac ggtatttcct tcccaatatg 2168041 acgtgatggc ttcttcagcc tccaacacat caaggtgacc tgccgtttct gacatcgtta 2168101 aaaacaattc cttttcatat acagcaggaa aaagctgctg acagacctga aaagcggtca 2168161 tcggcttttc atccagcatg cgacgcacat cctccgtcct gttcctctgc ttgtcaaaac 2168221 gcttctcaat cagcgcttgt acactggtga taggctcgcc gtgaccagga aatacgattg 2168281 ttggatcaag ttgagacagc cttcgcaatg accgctgata atccactaaa ggctttgacc 2168341 tgacgtctcc cgctttcggc gcttccaaaa tcggattaga cgagctgttt gccagcagta 2168401 gatcgccgcc aagcatcctt ccgctttttt catggaacag aacaatatgc gattcagcat 2168461 gtccaggcat ctccaacaca gaccagccct caagcccatc tatgcccata ccttctctga 2168521 ttgattttgt cagagatctc gtacaggaaa atgcgtacgc tgatcgaatc agcttttccg 2168581 ccttccccgt atcaaatgga acgcctaatt caggcagcag cttttgaaaa aaacgttttt 2168641 gccaatccat aaaggcttga ttttggctga tataaggttc gttgaatgta tgcccaatca 2168701 cttcgatttc atctgaaaag acatcaagca agcctgcatg atcagcatga tggtgagtca 2168761 gtacaacctg ctcgatatct gacaatttca catttacagc ggcaagctgc tcttgtaagg 2168821 ctctggcagc ctcttttgta ttcggcccgg catcgataag tgtcagcgca tcacctttta 2168881 cgaggtaaac gataacatcg ccgacagcaa acggtgtcgg gacgcggatc gcaattacat 2168941 cttcagttgt catcctttcg ctccttgtct tcattcatta ttcatatttt agctttttct 2169001 cggtcttgtg tcattattgc agaatgagaa caaacctttt tgaaaaagct attgacatta 2169061 gcttgtccgc cattgcataa tgaacaacaa actaaaacga gaaccattgg aacgctatga 2169121 cgaggaatag tatacaaggc aatggcctaa gagagcgata cccccggctg aaaggtgttg 2169181 cggcccgctt gtttgtagaa cctgccctca agtcgcggtt aggaaaacct aaacgtttcc 2169241 cgcgttacgg ggatttgagc tgagcacaat ttgtgctaat gagggtggta ccgcgaacct 2169301 tttcgtcctt tacgtgatga aaaggttttt tgttgttcta atagaaggag gatatcaatg 2169361 aaaaagatag gatttgtcgg cgccgggtca atggcagaag caatgatcaa cggcattttg 2169421 caaagcggca tcacaaaacc agaacatatc tatattacaa atcgctcaaa tgacgagcgt 2169481 ctgattgaat taaaggaaac gtacagcgtg cgtccatgca gagataaaaa tgagtttttc 2169541 actcacaccg atatcattat cctcgctttc aaaccgaaag acgcggcgga aagcatcgac 2169601 agcatccggc cgtatatcaa ggaccagctt gtcatttcag tacttgcagg ccttaccatc 2169661 gaaaccattc agcattattt tggcagaaag ctcgcggtca ttcgcgtcat gcctaataca 2169721 tcagcggcaa tcagaaaatc agcaaccgga ttttccgtaa gcacggaagc aagcaagaat 2169781 gatattattg ccgcaaaagc tctattggaa acaatcggtg atgcaacact ggttgaggag 2169841 cggcatcttg acgctgtcac tgcaatcgca ggcagcggcc cggcctatgt gtatcgttat 2169901 attgaggcga tggaaaaagc agcacaaaaa gtaggattag ataaagaaac ggcaaaagca 2169961 ctcattttgc agacaatggc aggggcaaca gatatgctcc tccaaagcgg caaacagccg 2170021 gaaaagctgc gtaaagaaat caccagtcct gggggcacta cagaggcagg tcttcgcgct 2170081 ttacaggact cccgctttga agaagcaatt attcactgta ttgaagaaac agctaaacgg 2170141 agcgcagaaa tcaaagaaca gtttgccggt gccgccttag agagacattc ttagatgtaa 2170201 ggacaaaaac agaaggcaca gtgccttctg ttttttattt ttcccgcagc agctggccgg 2170261 cagattctga ttgctttaat agcgcggaga tcgtaaatga aagcaaatcg ggaagcactt 2170321 caaaggaata aggcatatac aatctttccg tccatttatg cgggtcttta ccagccggac 2170381 cgacatttaa aactgggaca tataaagcct gatttttacc gcttggcaat gaataccctc 2170441 tgttaaagag cggcatattg cttgtgtatg catcaacctc ctgtttttcc agctgaagat 2170501 aactcaagtc cgaaagtccg gggaagtact gaacctcccg taatgcaatg ccgtatcgct 2170561 cagccgcata atgctttatc tgatctgctg tatttctgat caattgatca tcctttgaag 2170621 aaacagctgg ataaagcggc ggactataaa acagaacgat gagcggcgca tcctccttac 2170681 aaagcgaagc aagctcagaa acaattttcg tcgaaaaatc cctgtctcca agctcccccc 2170741 tgttagcaaa ggcataattt agagcccgct ctgtttccga gatccccgca cgcttttttg 2170801 cacgcgagac cagctcatca aatgtcaaaa cagtgacgtc ccgctcaatc ggctgaaatg 2170861 gctcaaattg ttgaaaatcc tgtgttttct tccgaacgtt cgacatgatt tcctccgccg 2170921 cctgttctgc tgttttaagc agcatctgat gcagctcact agctgagcgt ttcattgaca 2170981 gcacattaaa taatgtgacg gctgtatgcg gtgtctggac tgaatatgcc tctttcaagt 2171041 ccttttgcat taagtttacc ggcggcggag tgacctcgcc atcaaccttt tcgcaataat 2171101 cagcattcag ttcaagcaaa cggttaatct cagataccat taaatttgcg tttagacctg 2171161 aaaacggctc tccaacatgt gtctcaatcc ccttgcagaa aaaacccgca agcaccttgc 2171221 caatgcttcc tgtataaaaa tattgctgct gatcgccggg aaatttttca aacatcggtt 2171281 cggcattcag gcaagcggtt aatgtgatat catgcttttt ctccatctcc ttcaatgcag 2171341 gaaccgcttc aatcatgcct cttgaattca cttcctcgtc cggaaccgtt atcaacagca 2171401 gattgccctc aaaatgcccg ttcattgccc tctccagcat cgacagttga atacaaagcc 2171461 ccgctttcat atccatcgtc cctcttccga acagccagtc tccgctttcg gcatctcttc 2171521 tcacacgttc cgggagcagc tcttttttct ctaaaaagga gctcaaaagc tcagcaggct 2171581 tgcaagccat atgtttaaat tcgccgtaat cttctatgtc aacgacatca aaatgactca 2171641 gcagaagcac tgtctttttg acattcttct ttttgactag agccgtaaga aaagatctgc 2171701 catcgtccat cggatgaagt gttacatcat cagggtgctt ttgaaaatag ggcttgtcct 2171761 tcaaaataaa ataaagatac tctgcaagcg ctacctcgcc ctttgaaccg gtgatgcttt 2171821 cgtattgcac aagagaagtt aaaagtgcca gcaattcgtc cttcgtctgc caattcattg 2171881 attccgcccc tcctatgaat aaaaatgctt ctatactgaa aaataaactg atttctcgtc 2171941 tattatacag aaatgtttga caaaagcggt tcatttgagc agtttatatg acgggaaaga 2172001 aatgacttga tataatcaat ctctaaaaac cttacgggag gcgaaagaaa tggccagaaa 2172061 attatttaca cctattacaa ttaaagatat gacgttaaaa aaccgcattg tcatgtcgcc 2172121 aatgtgcatg tattcttctc atgaaaagga cggaaaatta acaccgttcc acatggcaca 2172181 ttacatatcg cgcgcaatcg gccaggtcgg actgattatt gtagaggcgt cagcggttaa 2172241 ccctcaagga cgaatcactg accaagactt aggcatttgg agcgacgagc atattgaagg 2172301 ctttgcaaaa ctgactgagc aggtcaaaga acaaggttca aaaatcggca ttcagcttgc 2172361 ccatgccgga cgtaaagctg agcttgaagg agatatcttc gctccatcgg cgattgcgtt 2172421 tgacgaacaa tcagcaacac ctgtagaaat gtcagcagaa aaagtaaaag aaacggtcca 2172481 ggagttcaag caagcggctg cccgcgcaaa agaagccggc tttgatgtga ttgaaattca 2172541 tgcggcgcac ggatatttaa ttcatgaatt tttgtctccg ctttccaacc atcgaacaga 2172601 tgaatatggc ggctcacctg aaaaccgcta tcgtttcttg agagagatca ttgatgaagt 2172661 caaacaagta tgggacggtc ctttatttgt ccgtgtatct gcttctgact acactgataa 2172721 aggcttagac attgccgatc acatcggttt tgcaaaatgg atgaaggagc agggtgttga 2172781 cttaattgac tgcagctcag gcgcccttgt tcacgcagac attaacgtat tccctggcta 2172841 tcaggtcagc ttcgctgaga aaatccgtga acaggcggac atggctactg gtgccgtcgg 2172901 catgattaca gacggttcaa tggctgaaga aattctgcaa aacggacgtg ccgacctcat 2172961 ctttatcggc agagagcttt tgcgggatcc attttttgca agaactgctg cgaaacagct 2173021 caatacagag attccggccc ctgttcaata cgaaagaggc tggtaatgcc cataagagat 2173081 atcctgtaga ggatatctct ttttttattt ttagagaaac gatcggctaa ggttctccgt 2173141 ctccctagta gaaccaatta gaggagatga ctccaatgaa atcagcttgg atggaaaaga 2173201 catatacaat tgacggatgt gcgtttcata cacagcaccg gaaaggatca agcggtgtaa 2173261 cgattgtctt tgaggccggc tatggtactt cttctgagac gtggaaacca ttaatggcgg 2173321 acattgatga tgaatttggc attttcacat atgatcgggc aggcatagga aaaagcgggc 2173381 aaagcagagc taaacgaaca gctgatcaac aagtgaaaga attggagagt ttgcttaaag 2173441 cagctgatgt aaaacctcct tatttggctg tttcacactc atacggagct gtcatcaccg 2173501 gtttatgggc ctgcaaaaac aagcatgata ttatcggcat ggtccttctt gacccagctt 2173561 taggcgattg cgccagcttt acctttatac ccgaagaaat gcacaaatca catacgagaa 2173621 agatgatgct tgagggcaca catgcagagt tttcaaaaag tctgcaggag ctcaaaaagc 2173681 ggcaagtcca cttaggaaac atgcctcttc ttgtgttgtc atcaggagaa cggactgaga 2173741 aattcgctgc tgaacaggag tggcaaaact tgcacagcag catattgtct ctatctaacc 2173801 aaagcggctg gattcaagct aaaaacagct cccacaacat ccatcatgat gaacctcata 2173861 tcgttcactt ggctatttat gacgtatggt gcgcagcgtg ccagcaggcc gctcctcttt 2173921 accaggcagt caattaacgt aaaaaaagac cgggccgtaa gggattcccg gtcttttata 2173981 ttattttgtt tcacggtgaa gggtatattt ctttaaacgc ggtgaatatt ttttcagctc 2174041 caaacggtct ggattggtgc gtttattttt tgttgtgatg taatttcggt ctcccgtttc 2174101 agtgcaaagc taaagtaaca tttactctca taattaacat ctccttataa aacgtaatga 2174161 ttacgtttta ttatacaacg tcatcacaaa ttgtcaaata agagctccgc cttcagcctc 2174221 gcgggacgtt tacctctaag aaatcatatg ccgccacgct attggggaaa acgtcaaccg 2174281 cttctttttg aagctccaaa gaagcatctc cctgatatct tgcgctgata tgggttaaaa 2174341 tgagctgctt cgctcttgct tctttcgctg ttacagccgc ttgttccgtt gtactgtgat 2174401 aataatcata agcaagttta cggtcttcct tagcaaaggt tgcttcatga acaagcacat 2174461 cacaatccct cgcaagctct tttagtttgt cacttactct cgtatcaccg gagaacacaa 2174521 cagatcttcc ctttttagga ggctccagaa aatcattccc attgatgatt cgtccgtctt 2174581 caagcgttac cgtttcgcct tttttgattt tctgatatac aggtccgggc gggatgttca 2174641 tttcttttaa tacgtcagcc ttcaaggaac ccggtacgtc tttttcctgc acacggtacc 2174701 cgaaggcttc cactccatga ataacagata ccgctgtgac aataaactga tcgtcctcaa 2174761 acacgattcc ttcttcaatt tcctggatcg caagcggata tgtcaaatgg gttttcgtga 2174821 cggcaaggct tgtttcaata aacgccttga tccctttagg tccgtacact gtcagctcgt 2174881 cctctccgcc ttgaaaggaa cggctcccca gaagccccgg aagtccgtat acatgatcgc 2174941 cgtgcatgtg tgtaataaag attttctcta ttttacgagg tttaatcgtt gtatgtaaaa 2175001 tttgatgctg tgtggcttcc ccgcagtcaa aaagccatac cgaacgcctt tcttcaagca 2175061 attttaatgc caccgacgtt acatttctcg ccttggcggg gatgccggct cccgtcccta 2175121 aaaaaagtaa ttccacgttt ccttcctcct actagaacca gatacctaca agaatacagg 2175181 atcaagcgga aaatgtgaat cttgcctctg aaaagaacaa tcctttcgtg ctagaaacat 2175241 tttttcagca ttctgcttaa aaaagggctt aaatgtttgc tttcgttgaa ttttagattt 2175301 aaaatgaagg aaatatacgg ggtgtactaa aataaagctt cgaataaagt gaggtacttt 2175361 tagtgaaaac aaaccaacaa ccaaaagcag taattgtcat attcggtgca actggagatt 2175421 tagcaaaacg aaaattgtat ccgtctattc accgtttata tcaaaacgga caaatcggag 2175481 aagagtttgc agtggtagga gttggaagaa gaccttggtc taatgaggat cttcgccaaa 2175541 ctgttaaaac atccatttcc tcatctgcag ataagcatat agatgatttc acgtctcatt 2175601 tttactatca cccgtttgac gtgacaaacc ctggttctta tcaagagcta aacgtattgc 2175661 ttaaccagct ggaagataca tatcaaattc ctaacaacag aatgttctac ttggcaatgg 2175721 ctcctgaatt cttcggaacg attgcaaaaa cattaaaatc agagggtgta acagctacaa 2175781 ccggctggtc ccgccttgtc atcgaaaaac cgttcggcca tgatctgcca agcgcacagg 2175841 cattgaataa agaaatccgc gaagcattta cggaagatca aatttacaga atcgaccatt 2175901 atctaggcaa acaaatggtt cagaacattg aagtgattcg atttgccaat gcgattttcg 2175961 aaccgctttg gacaaaccgc tacatttcaa acattcaaat cacatctagc gaatcactag 2176021 gcgttgaaga ccgcgcaaga tattacgaaa aatcaggcgc ccttcgcgac atggtgcaaa 2176081 accatattat gcagatggtt gcccttcttg caatggagcc gcctatcaaa ttgaacacag 2176141 aagaaatccg cagcgagaaa gtgaaggtgc tgagagcact gcgtcctatt gcaaaagacg 2176201 aagtggatga atactttgtg cgcggacaat atcatgctgg tgaaattgac ggtgtaccgg 2176261 ttcctgctta tacagatgaa gataatgtcg ctcctgactc caatacagaa acctttgttg 2176321 ccggcaagct cttgatcgac aacttcagat gggctggtgt tccattctac atcagaaccg 2176381 gaaaacgaat gaaagaaaag tccacaaaaa ttgtcgttca atttaaggac attccgatga 2176441 acctgtacta cggtaatgaa aacaacatga atccgaactt gcttgtcatt catattcagc 2176501 ctgacgaagg cattacgctt tacttaaatg ctaaaaagct tggcggagca gcacacgcac 2176561 agccaatcaa actcgattat tgcagcaatt gcaatgacga gttgaacacc cctgaagcat 2176621 atgaaaaact aattcacgac tgtcttcttg gcgatgcaac aaactttgca cactgggatg 2176681 aagttgccct ttcttggagc tttgtcgact ctatttctga aacatgggca gcaaacaaaa 2176741 ccttatctcc taactacgaa tcaggctcaa tgggaccgaa agaatctgat gatcttttgg 2176801 tgaaagacgg cttacactgg tggaacatat aataagaaga aaaaagccga aaatgtttac 2176861 aagcattttc ggctttttta cgctgaacaa aggtataaca atctccttaa taacaaaacc 2176921 cccaaagctt aagagcttcg ggggtttcta ttgattactt catccattca gtatggaaga 2176981 tgccttcttt gtcagtacgc tcataagtat gagcgccaaa gtagtcgcgc tgtgcttgga 2177041 ttaagtttgc aggcagtacg gctgtgcggt agctgtcata gtaggctaat gcgcttgaga 2177101 atgatggcac cggcacacct tgggcaactg caagtgaaat cacttggcga agcgctcctt 2177161 gatagctttc tacaatattc ttgaaatagc tgtcaagaag caggttgtca agctcaggct 2177221 cgcgatcgta agcttctttg atcttctgaa ggaatgccgc gcgaatgatg caaccaccgc 2177281 ggaagatcat agcgatttca ccatatttca gatcccagtt gtattcttca gaagcagctt 2177341 tcatttgggc aaatccttgc gcgtatgaac agattttact catgaacaac gcttttctga 2177401 ccgcttcaat cagctcttct ttattttctg taacaggctt cacttctggt cctgaaagaa 2177461 gtccgctcgc ttttacacgc tcttccttca tagctgagat aaagcgtgcg aatacagatt 2177521 cagtaataat cggaagcgga acgcctaagt caagtgcgct ttggcttgtc cattttcctg 2177581 ttcctttttg gcctgcttta tcaagaatca catcaacaag cggtttgcct gtttcttcgt 2177641 ctttttttgt gaagatgtca gccgtaatct caatcaggta gctatcaagc tcacctttat 2177701 tccattcagc gaaaacttca tgaagctcat cagcagaaag gcccagcacc tgtttcagaa 2177761 tgaaatatga ttcagagatc agctgcatat ctccgtattc aattccgttg tgcaccattt 2177821 ttacgtaatg gccggcgccg tccggaccga tatatgtcgt acaaggttct ccgtcaactt 2177881 ttgcagaaat ggcttcaaga atcggtttta caagctcatg tgcttctttt tgtccgccag 2177941 gcatgataga aggtccttta agcgctcctt cttctccgcc ggaaacgcct gttccgataa 2178001 aatgaatgcc gctttcagcg agttctttgt tacggcgctg tgtatcttta tagtatgtat 2178061 taccgccgtc aattaaaata tcatccttct ctagatgagg aagaagagat tgaattgtcg 2178121 catctgttgc agttcccgct ttaaccatta ataagatttt gcgcggtgtt tccaaggatt 2178181 ggacaaattc ttcaatgctg taagtgccaa caacattttt tccttttgcc tcctgtaaaa 2178241 actcctcagt tttactgctt gatctgttgt aaacagaaac agaaaatccc cggctttcga 2178301 tatttaaagc cagattttta cccatgaccg caagtccgat aacgccgatt tgttgttttg 2178361 acatattcta acgtcccttc tgcaaacgtt taatcatttt aaaatttaaa ttaaaataaa 2178421 atgatattta taataaagaa attaccatac attcaccctt tttttcaagc gattcagctt 2178481 ttcttttcat cttgaaaaaa atctttatta aagcttgttc cctttgtttt gctctcctct 2178541 ttttttaacg ttgccccttt tctgatcagt ttggtaccgt actttttatt cagcttttcc 2178601 atcatctgct gaatgggctc atccttcgca tcttcattaa agctgaacaa atcgagctgt 2178661 ttataggcct gctctttttc tactaaatcc gttccggtaa tgccaagcag cctgacagga 2178721 tttttattcc aatgtttaaa aaagaggtgc tccgcttctt tcaaaatgtc atttttttga 2178781 tcaatcgggt ttctcagcgt agtgcttctt gtgatggttc tccaatccgc atatctaatc 2178841 ataataaaaa gcttcgaagc catgacttcc ttgcgctgta aacggtcact cacagaagcg 2178901 gcaagctttc taaaaacgcc taacagctct tcttcatcac tggaatcatg ggaaagtgtc 2178961 gatgagttgc cgacgctttt aaattcgtaa atgcgctccg ggtcaaccgg cgcatggtga 2179021 atgccatttg ctttattttt aaggcgcgga ccgttgatgc caagcaggcg cttcagcgag 2179081 tgttcatcag ctgcagctag ctctccgatt gtatggatgc cgagtccctt cagtttttcc 2179141 gctgtctttt tgccgactcc gtgcatctct ccaacaggaa gcggccacag gatatcgggc 2179201 acttgcctct ttcttaagat cgtaattcca agcggttttt tcatatcaga cgccatctta 2179261 gcgagaaatt tattcggtgc aatccctatg cttgacggga gcagcagctc tttttgcagc 2179321 ctgctttgga tttcttttgc cgtctctaga gcgcggctgc tgtatggtgt atcggtcatg 2179381 tccatatagc cttcgtcgat ggagacaggc tccactaggt cagtatattc acgaagaatg 2179441 gtaaacatcg ctcgtgaaga gtttctatag cggtcaaagt tcggcggaag aacgatgagc 2179501 tcaggacaat ggcgcttcgc ttgccaaacc ggcatcgttg ttttgacgcc gcgcgctctt 2179561 gcttcgtagc tgcatgttac cacaatgccc tttcgctcct ttacgtttcc ggcaactgcg 2179621 accggctttc cccggagagc cggatcatat gccatttcaa ccgacgcata aaagctattc 2179681 atatcaatat ggaaaataat tcggctcttt cccggcataa acaaatctcc ttttcggtca 2179741 ttagacaaca gcttgtacat atagtaaaat gaagctattg aatggatgtg atgacaatgt 2179801 ttgtggaatc gataaatgac gttttattct tagtcgattt tttcacaatt attcttcctg 2179861 ctctaacggc aatcgggatt gcattcctct tacgggagtg ccgtgcgggc gagcaatgga 2179921 aatcaaaacg aacagatgaa catcagacgg tctttcacat taaccgaaca gactttctta 2179981 ttattatata tcatcgcatt acaacttgga tacgtaaagt cttccgcatg aattcgcctg 2180041 tgaacgatga ggaagacgcc ggttctcttc ttttataaac cgcatttata aaaaggagga 2180101 gaacaaaatt gttaaaaaca tatcaaaaac ttttggctat gggtatcttt ttgatcgtat 2180161 tatgctcggg caatgctgca tttgcagcga ctaatcaggt gggaggcctc agcaacgtag 2180221 gttttttcca cgattattta atcgaaccgt tttccgctct gcttaagggt gttgccgggc 2180281 tgtttcacgg agaatacgga ctctctatta tcctcgtaac cattattgtg cgtatagttg 2180341 tattgccttt gtttgtcaat cagttcaaaa aacagcgcat cttccaagag aaaatggccg 2180401 ttattaaacc tcaggttgac agtatccagg ttaagttgaa aaagacgaag gacccggaaa 2180461 agcaaaaaga gctgcaaatg gaaatgatga agctgtatca ggagcataat atcaacccgc 2180521 ttgcgatggg ctgtcttcca atgctgattc agtctccgat tatgattggg ctttattacg 2180581 cgattcgctc aacacctgaa attgcgtcac actcgtttct atggttcagt ttagggcaat 2180641 ctgatattct catgtccctt agtgcaggga ttatgtattt tgtccaagcc tatatcgctc 2180701 aaaaactgag cgcgaaatat tccgctgtcc cgcaaaaccc tgcagcgcag caatccgcaa 2180761 aattgatggt gttcatcttc cctgtgatga tgacgatttt ctcgcttaat gtgccggcag 2180821 cccttccgct gtactggttt acaagcggac tgtttttgac agtgcaaaac atcgtccttc 2180881 agatgacgca tcataaaagt aaaaaaacag ccgctcttac tgagtcggtg aaataaaaaa 2180941 gcaaccccgt gcaaaaagcc ggggttgttt tttgttactt gcaaagtacc gcgccaaaca 2181001 gtcttgttta tcatggctga agcagaaatg gccatcctaa aaaatagccg tatcgtttaa 2181061 aaagaaggaa atcgggaata cctttactca cctccaaccg aaaggagcct atacgttgac 2181121 ggaacgcttt cagcaaaaaa atatttctgt acctgatgga atctggatca tgagacaaac 2181181 ctggaatgat gtcttatttg ctcactggcc tgttgatgtt tctatccttc gcgctttggt 2181241 accgtccgtt ttagaattag atacatataa cgggcaagct tggatcagca tgcttccctt 2181301 tatgctcacg aacctgaggg cgcgttatct ccctgtcatt cccggtgcgc gtgcatttcc 2181361 tgagcttaac ctccgcacct atgtcacgta taaaggcaag cccggcattt atttttttag 2181421 cttagatgcc gatcatcgtc tggcggtcct tggcgctcgc acattctttc atctgcctta 2181481 tttttacgcg gatatgaagt ccgaaaaaaa cggtgatgcc attgactatg tcagcaagcg 2181541 gaaaaatgac aaagaagcag cattccacgc cgcataccgg ccaatttcag cgccttttac 2181601 agcagaaaag gattcgctcg attactggct gacagaacga tacaggctct acaccactta 2181661 tcgcaataag ctctattacg aagacatcca tcatcatccg tggctgctgc aaaacgccga 2181721 agcagaaatt tcagtcaata cggtgactga tgctcacggt attacattgc cggagtcaga 2181781 ccccttgctt cattatgcta aaaaacagga tgtgttattt tggccgctta ggaaatggag 2181841 ctaaaaaaac ccgatgcggg aaatcgcact cgggttttct ttttttattt tgccgcctct 2181901 tcaataatgg caacaaccat ttctgccgtt ttaacgagct cttcgatcgg cattttttca 2181961 ttttttgtat ggatttgctc ataaccgaca gcaagattga ccgtcgggat gccatgacca 2182021 gcgattacgt tcgcgtcgct tccgccgccg ctcgtttgca gctcgcttgg acgtccgatt 2182081 ttagcagccg cttttttcgc gatttcaaca acttggtcgc cgtcttgata tttaaagccc 2182141 ggatacataa cctcaatttc gacttctgcg cgtccgccca tatcagcagc tgcctcttca 2182201 aaagcagctt tcattttttg aacctgagct tccattttct caggaactaa agagcgcgct 2182261 tcagcaagaa tatgaacttc gtcgcacaca atgtttgttt gtgtgccgcc ttcaaaccgg 2182321 ccgatattag ctgttgtttc ttcatcgata cggcccaatg gcatttttga gatggctttg 2182381 ctagcgattg taatcgctga aatgcctttt tcaggttcaa ccccggcgtg agcggttttc 2182441 ccgaaaattg ccgctcttac cttcgcctgt gtcggcgcgg ccacaatgat atttccgact 2182501 tttccgtctg aatcaagagc atagccgtag gatgcagtga tcatagaacg gtcaagcgcc 2182561 ttcgctccga tcagacccga ttcttcccct actgtgatga tgaattcaat cgtgccgtgt 2182621 tcaatatttt cttctttcag caccttaatc gcctcaaaca ttgcagccaa tcccgcttta 2182681 tcatcagcac ctaaaatcgt cgtgccgtca gttttgacgt aaccgttctc tacaactggt 2182741 tttacgccgt ttccgggtac aactgtgtcc atatgagatg taaaatagat cgtatctgtt 2182801 tgttttgtcc cttttagcgt gcaaatcagg ttaccggctc cgtggcccgt gatatccatt 2182861 gtatcgtctt ctttaacgtc cacacctaaa tcagaaaatt ttcgtttcag cactttgcag 2182921 atttcagctt cgtgctttgt ttctgagtca atttggacaa gctctaaaaa ttcttccagc 2182981 aggcgttttt cattcaccat ttgtaagtcc ctccatatta aagcggtatg ttaccgtgct 2183041 tttttttcgg tctctcttct gtcttatgtg taagcatatg aaaagcttga atcagtcttc 2183101 cccttgattc ttccggcaaa atgatgtcat cgaccattcc acaagcggcc gctttgtatg 2183161 ggccggcgtt ttgctttttg tattcagcag ttttttcgcg tttcgtcttt tgcgggtcag 2183221 ctgaagcttt gatttccttt tcatacaaaa tcgatgccgc accttctgga cccatcactg 2183281 cgatttcagc attcggccat gcaaacacaa ggtccgctcc gatcgctttg ctgttcatgg 2183341 ccacataggc gccgccgtac gcttttctaa tgatgagtgt gacttttggg acagtcgctt 2183401 cagcataagc aaacaataat tttgctccat gcctgatgat tccgttgtgc tcttgctgaa 2183461 tacccggcag aaaccccggg acatcttcga cagtcaacag cgggatatca aatgcgtcac 2183521 aaaaacggat gaaccttgct gctttatcag cagcgtcaat cgtcaggctt cccgccagat 2183581 gcttcggctg gctcgccacg atgccgattg ctttttcacc cagccttgca aacccaatga 2183641 caatgttctt cgcaaaaaat ggctgaatct caaaaaaaga ctgcgggtca gccagctccc 2183701 taatcacctt ccgaacatca taaggctttg tcgtatcagc agggacaaga cggtttaata 2183761 acggtctgga cgcctctttc tctggcttcg gctctgttgt ccggccattc agcggcaaat 2183821 aagacagtag ttttctcacc cctgtcagaa cctccttctc cgtatgcccg gaaaagtggg 2183881 cgtttccgct gacggcatta tgtatccccg ctccgcctaa gctctccgca tcaacctgtt 2183941 cccctgtcac tttttcaatc accttcgggc cggtaataaa catccggcca gtctgttcag 2184001 ccataaatat aaaatctgtg agtgccggag aatatacagc gcctccagcg cacggcccta 2184061 aaataaccga tatttgcgga atgactccgg aatataagac gtttcggtaa aatatgtgac 2184121 cgtatccatc taatgataac acaccctctt gaattctcgc accacctgag tcattcagcc 2184181 cgataatcgg cgccttattt tttgctgcca gatccatcaa agcgcagatt ttcctggcat 2184241 gggtttcgcc aagcgcccct ccgtacactg tgaagtcttg cgcaaataca taaactgagc 2184301 gaccgtcaat tgtgccgtac cctgtcacga ccccatcccc taacatgcgc tgttctcttg 2184361 ttaacacttg actttccatg aaggggtgta attcgataaa gctgtcctga tctagaagaa 2184421 atatgatcct ttcccgagca gtgagcttgc ccttttgccg ctgctgagcc agcttttccc 2184481 gtcctccgcc ttcttctgcc tgcttgcgtt tcgtgtaaaa atgatccatg tgctcattca 2184541 tgctcattgt gttggtctcc tttcggttca caaagctcta caagaacacc gtttgtttcc 2184601 cgaggggaaa taaacgcgat ctttttcccg ttcgctccct gtcttggaaa cctgtcaatc 2184661 aattgaacat gctgatcaga caatgcttga agctgttcag ataggcagtt gcacaaaaac 2184721 gcaatatgat gcagtccctg ccctttcttc tccaaaaata aatggacggg gctgtcagct 2184781 gtcaacggct ctatcagctc aagtttgacg ctaccagctt gaaaaaaagc aacattcacc 2184841 ttttgctctt caaccgtttc ttgatgaaga aatgcaagcc ccaatacatt ttcataaaag 2184901 cttcttgcat cttttatcga aaaaacggct atcccgatat ggtcaagcct gttcattttc 2184961 atccctgctt tcgctaatag atatcgcttg tccgcccatt caaaacacgc taaaatatag 2185021 acagattgtt taaggagtga aaatcatgtc tcaaaaactg atgaaaagcg ttttgatcgt 2185081 gattttggga gtttttattc tttcaactgt actctcagga atcgtcatgt ttctataacg 2185141 ataaaaaagc aggcgcctta ttcaatggga atatcctgct tttttatcag agctttatgc 2185201 tcgatggcaa tctcctcaaa agagcggttg tcgtccgtga tcagcactct cgttcctact 2185261 ggtatcgttt gaaacaaatg aacaacctca tcgttatgca tacgtataca gccgttagac 2185321 acaaattttc ctactgattc ctctcggttt gtcccatgaa ttccataaat ccgcccgtcc 2185381 gttcctttcg cgtcaaatcc gatccatctt gccccaagcg ggttatcagg agatccccct 2185441 tcaatatttt tctttctgta gtaaggattt tccgctttta ccgttaccga aaactctcct 2185501 tcaggcgtca aatcatctgt ttttccagtc gccacactat acacgccttc tactttgttg 2185561 tcgaggataa cagcaagttc atttgttcgc ttgttgacaa taacatacgg atcacccggc 2185621 agcggatttt cgccgagcgg ccaaatcggt gaaatcatca tgaaaatcga acataagaaa 2185681 aaacgcataa gctcctcctt tttcattagg ttgaccaatg aaggaagagc tcatgcgaat 2185741 catccgagtg atttttgcgc ttttattcct ttaaaataac ttttaatcac taaatattgt 2185801 tccatttcgc cgagaagatg gaagagagcg gccctcgctt caaattcctc tctagtcgca 2185861 ggaagcggca tctcctcaaa ttcttttctc atgtcagcaa gtcttttcag aaatttgtat 2185921 gctgtattcc cagggtgtat cgcctcccgc aaatcatgaa taaattcagc gatcattttt 2185981 ccctgatcta ccgtgatgga gatcgatgtc actttaggga gaaggcgttc gataatttca 2186041 aattgctttt ctctcatttt aaaataatga taatgcagat tttcataacg caaaatgtgg 2186101 ttttgcacat ctcgatatgc caggttttta gcctccgtaa tgagctggtg cgtttccgga 2186161 atttcttttc ctgaccaatc ttgctcacca gttaacaaat accgttcgat ttctgcaaaa 2186221 atgacagcaa agttatcctc tatctttttg cggtaggcaa tcagtttccg gtcaagacta 2186281 ggcatataca agttcatcaa tagagcgacg ccgatgccaa ccgtaatcag ctgaacttca 2186341 ttccagatga aagtaggcgt aatgccgccg gacatgtata aatgaaggat aataacagaa 2186401 ctggtgacga taccctcgtt aatttttaac agaaccgtta tcggaatgaa tatcaaaaga 2186461 agcgctccga tcacaaacgg gtggtagcca ataagctcga aaaagagata agaaaaagca 2186521 attgccagac agcatgccga aaagcgggcc catgaggcct gaagcgaccg tttttgtgtg 2186581 atttgtatgc acaaaatggt gatgattcct gctgatgcga agttttgcaa atgcaataac 2186641 tggcttatat aaatagccaa agctgttcca agcgcggtct ttattgtgcg gtaaccaatt 2186701 ttaaacatgt cggactccat ttctatttgt ttcttcaata aaaaagaaga ggcggccagc 2186761 cttcttcttt tttatattct ataatatttt ctctaaaaag tcctgcgctc ttttggattt 2186821 tggcgacata aaaaattcct tcggattgcc gtcttcgaca atcattcctt ggtccataaa 2186881 cagcacacgg tctgccactt cttttgcgaa gcccatttca tgtgtgacaa tcaccatggt 2186941 catgccggtt tcgaccagct ctttcatcac ctgtagcact tctttgacca tctctggatc 2187001 aagggcggag gtcggctcgt caaacagcat gatgtccgga ttcatcgcaa gagccctggc 2187061 aatcgcgaca cgctgttttt gtccgccaga caaacggttt ggatagtcat ttcgcttttc 2187121 aaacaaaccg actttgcgga gcaggtcctc agctttctcc tgtgcagcct gttttgattc 2187181 tttttttaca ttgacaggcg cgtacatgat gttttcgaga accgttttgt gcggaaagag 2187241 atgaaaatgc tgaaaaacca tcccgatgtt ttcccggacc tttaatgtgt tggttttcgg 2187301 cttcgtaatc tctgtgtctt ttattgtaat ggttccgccg ttaggctttt ccaacaggtt 2187361 taaacagcgt aagaacgttg atttgcctga gcctgaagga ccgatcacgg caacaacctc 2187421 accctcagcg attgttgttg aaatgttttt taatacttcg tgtttcccaa atgattttga 2187481 cagcttttca accttaatca ttggatttca gcttcctttc tacagccttg ccgataaacg 2187541 ttaaaatcag gacaagcaca taataaatca atcccgcgat aatgagcggc tcaaggtaat 2187601 tgtaagtggc ggcgccagct tgatatgcgc gtctcatgac atcaccaagc ccgatgacgg 2187661 tgacgatcgc cgattctttt gttaacgtaa ttaattcatt cacaattgca ggtgatatat 2187721 ttttgaaggc ctgcggcagc agcagatcct tcatcatttt tccatacggg acaccgagtg 2187781 caacagcagc ttctttttgc cctttatcaa tggcattgat tccggctctg ataatttccg 2187841 atacataagc ggcggaattc aaagacaatg cgacaaccgc agcccaaaac tggtcaattt 2187901 gaaatccgag cagctgagga aggccaaaat agacaatcat aagctgcagc actaaaggcg 2187961 tgcctcggaa cactgatgta taaaaatcag cgatccagat aaacgggcgg aatgtgctga 2188021 tcttgcataa gcttagcaca ataccgagta taagtccgat aatagcagat acaacaacaa 2188081 tttttaatgt aattgccaag ccttctaata taaaaggaat ttgggggatc gttgctgaaa 2188141 aatccaaatt catagccttt gtctcctttt cttacaggaa aaaagtttcc tattcaataa 2188201 aaaggctcaa cgaaaaagtt gagccgcttt tttttacttc tcgccagtga accatttttt 2188261 cttcaatttc tcaagctctc cgttatcttc catttccttg agcgctttat tgaatttgtc 2188321 tgtcagttca ctgtcctttc tgaaagcaat tgctgaaccg gcttcttccg ctttcgcatc 2188381 aggaatcaca aagccttgca ggtcatcatt tgatttgaaa tacccttctg caacaatgtc 2188441 ttcaataatc gcggcatcga agcggtcaga tttgatttcc tgcaccaaat cagaaattct 2188501 gttgcggtct tctgttttaa aaccatattc cggagaaagc tctttcccct tctcttcctg 2188561 aatagagcca agctgaacgc caactgtttt tcctttcagg tctttcaaag attgaatgcc 2188621 gctgtctttt ttgctgacaa tcatatggtt cgctgtgtaa tacacatcgg aaaaatcaac 2188681 ttgtttttta cgctcaggcg ttggtgtcat tcctgacaga acgagatcca cctgttttga 2188741 tttaagcgct gtaattaagc tgttgaagtc catatcctgc acttcaattt catagcctgc 2188801 cttctttgcc agagcttttg ccagctctac atcaaagccg acaatattat ctccttcttt 2188861 atattcaaac ggtttgtaat ccgccgaagt acccataatt aattttttct ttccgctttc 2188921 tgaacctgaa ttgcttgagc cgcacgcagt taatgcaaag gtgatgcaag cagccacaag 2188981 taataagagc cattttttca tgatccattt cccccgtatt cattactttt ggtgtatttg 2189041 aatatttatt cgttaatttg tattttaaac agtttctcat ttttatgcaa tactattttt 2189101 aaaaattatc tttaggctta tctttccagt gatctcttct gatattacta gataaaaatt 2189161 aaatcgctgt acaatccgat tgaataatcc cttaatattt attcatatat ccttggaaat 2189221 ttatgcacaa aaaaacccgg gctgctttga gcatccgggt tgttcgtctt atacttcttc 2189281 acaatattct tcaaaggctt cctgcagctt tgccactaca gccatcggct catggccttc 2189341 aatttcatga cgctctacca ttttcatgat ctttccgtct ttcaaaatcg caaaggacgg 2189401 agaagatggt ggataacctt caaaatagtc acgcgcacgc gctgtcgctt ctttatcctg 2189461 tccggcaaaa acggtgacga gctgatcagg tcttttatca tagtgaacgg aatggtaggc 2189521 tgccggtctt gcaattcctc cggcgcatcc gcaaacagag tttaccatga cgagcgtcgt 2189581 tccttttttc gtaagtgcct catccacctc ttcggctgtt ttaagctcgg tgtatccggc 2189641 agctgttatt tcttgtctcg cttggcggac aatatcattc ataaataaat taaagtccat 2189701 gttcaatgaa gacctctcct ttttcatcat ctgttcttat gatagcaagg aaacgtccat 2189761 atcggcaaat gactttgctt cgccgtgcac tttttttgct cttcgtttac tgcttacaga 2189821 aaaaggggat tatataacca gaagtaaaat aaaggagcag ttgtatatga gccaccggaa 2189881 agcgttactg attcataacg gaaatgccgg caacaaaaat atagaaaaag cacttggtgc 2189941 tgtggtgccg gttttatctc accatttaga tgaggtgatt attaaacaga caaagaaaaa 2190001 ggatgatgcg tatcattttt gccgatccat tgatgattct gtcgacaccg tcttcattct 2190061 cggcggcgac ggcacgatcc atcaatgcat aaatgctatc agcgctctag aaagaaaacc 2190121 cgctgtcgga attttgcccg gcggcacgtg caacgacttt tcaagagtgc ttggcatccc 2190181 tcaaaatctt gcaaaggccg cggaagcact tatggcggga aaaaaaacca gcgtagacgt 2190241 atgtcagatg aatgaccgtt attttttgaa tttctggggg atcggcttaa ttgcagaaac 2190301 gtcgaatcaa atcaacgaaa cggaaaaagc attattggga aaaatcagct attttacaag 2190361 tgccttgcga accgtctcat ctgctgcatc gtttccgatg acattaaaaa ttgatggaga 2190421 agaaattaaa gaagaagccg ttatgctgct tgtgatgaat ggccaataca ttggaacgaa 2190481 tcgaattcct ctgcccgatg ccagtattga agacggctta cttgatgttc tcatatgccg 2190541 caataccaac ctcaccgcgc tgcgggagct gatgagcatg gaacaaggct caattgatcg 2190601 ttttactgga gagttgtcct atgtccaggc ttcccgtatc gagattgaaa cagacactgc 2190661 caaaaaggcg gatatggatg gagaagttta tacacataca cccgcagtca ttcaggtcct 2190721 gccacagcat atcgacatgc ttgttcccgc aaatgaataa ctgtcataag gctttagaaa 2190781 gattttgcaa atccgttgac tctcccctag gaggaggtct tacagtataa gggatacaca 2190841 cttgaaaaag gggaagtcat atggagaaga aaaatattac cttaactata ttattaacca 2190901 atttatttat tgcttttttg gggatcgggc ttgtgattcc agtaacgccg accattatga 2190961 atgaattgca tttatcgggg accgcggtcg gctatatggt tgcctgcttc gctattacac 2191021 agctcattgt ctcaccaata gccggacgat gggttgatcg cttcgggcgc aagatcatga 2191081 tcgtaatcgg cctgttgttc tttagtgtgt cggagttttt gttcggcatt ggaaaaacag 2191141 ttgagatgtt atttatctcc cgtatgctgg gcggtatcag cgcagccttc attatgcccg 2191201 gggtcacggc ttttattgca gatatcacga ccattaaaac acggccaaaa gcgctcggtt 2191261 atatgtcagc cgctatttca acaggattta ttatcggccc cggcatcggg ggatttttag 2191321 cagaagtcca ttcccggctg ccttttttct ttgcggcagc ttttgcactg ttagcagcca 2191381 ttttatcaat cctcacgctg cgcgagccgg aacgaaaccc tgaaaatcag gaaataaaag 2191441 gacagaagac aggctttaaa cgaatttttg cccccatgta tttcatagct tttctcatta 2191501 tcttaatttc gtcttttggt ttagcatcat ttgaatcttt atttgcatta ttcgtggatc 2191561 ataaattcgg atttacggcc agcgacattg ccattatgat tacaggagga gcgattgttg 2191621 gcgccattac gcaagtcgtc ttattcgacc gcttcacaag atggtttggc gaaattcatt 2191681 taattcggta cagcttaatt ctctcgacga gtctggtatt cttgctgaca acggtacatt 2191741 catatgttgc gattctgctg gtgacagtca ccgtatttgt cggatttgat ctcatgcggc 2191801 ctgcggtaac gacttacctg tcaaagattg cgggaaatga acaggggttt gccggcggta 2191861 tgaattcaat gtttacaagt atcggcaatg tattcgggcc tattatcggc ggaatgctgt 2191921 tcgatataga tgtaaactat cctttctact ttgcaacggt caccttagcc atagggattg 2191981 cactgaccat tgcttggaaa gcgcctgcac atcttaaagc cagcacgtga taagaagcgc 2192041 attctttgtg tactgcaaag aatgcgcttc ttctttatac tgatgataga aggagtgatg 2192101 gcatgaagga atcgtattac tcaattgggg aagtatcaaa actggcaaac gtgtcgataa 2192161 aagcgctccg ttattacgat aaaattgatt tatttaaacc agcctacgtc gacccggata 2192221 ccagctaccg ctattataca gattctcagc tcattcatct ggatttgatc aaatcattga 2192281 aatatatcgg cacaccttta gaagagatga aaaaagcaca ggacttagag atggaagaac 2192341 tgtttgcttt ttatacagag caggagaggc aaatcaggga gaaattagac tttttatcag 2192401 ccctggagca aaccatttca ttggtgaaaa agcggatgaa acggcagatg gaatatcccg 2192461 cgctcggtga ggtgtttgtt ttagatgaag aagaaatacg gatcattcag acagaggcag 2192521 aaggaatcgg gcctgaaaac gtgctcaacg cctcctacag caaattaaaa aaatttatcg 2192581 agtcagcaga tggatttacg aacaatagct acggcgctac tttctctttt cagccctaca 2192641 ccagcattga tgaaatgact taccgtcata ttttcacacc tgtattgacg aataaacaga 2192701 tttcatcaat tacgccggat atggaaatca caacgatccc taaagggagg tatgcgtgta 2192761 tcgcgtataa tttttcgcct gaacattatt ttctcaactt acagaagctt atcaaatata 2192821 tcgcggaccg ccaattaaca gttgtcagtg atgtatacga gttaatcata ccgattcatt 2192881 actccccgaa aaaacaagaa gaatatcgag tcgaaatgaa aatacggatc gctgaataat 2192941 aaagcataga aaaagagcat tttttgaaac aaaacttcaa aaaatgctct ttttgcttat 2193001 ttagtaaaca gatgtcttct cgtcaatcga ttctaaaatt tgtttcactc gtccgaggaa 2193061 tcgtccgcac acgagaccgt caagcactct gtgatctaat gacaggcaca gattaaccat 2193121 gtctctgaca gcaatcatgc cattgtccat gacaaccggg cgtttgacga tggattctac 2193181 ttgaagaatc gcagcctgag ggtagttgat aatgcccatc gactgaacag acccgaacga 2193241 acctgtgttg ttgacggtaa acgtgcctcc ctgcatgtca tctgcagtga gttttccgtc 2193301 tcttactttt ttagctaggc cggtaatgtc tttcgcaatg cctttaattg ttttttcatc 2193361 agcgttttta atcaccggaa caaataaaga atcctctgtg gcaactgcaa ttgaaatatt 2193421 gatatccttt ttctgaataa ttttgtcccc cgcccacatg ctattcattt gcgggaattc 2193481 ttttaacgcc tgagcgaccg cttttacaaa aaaggcgaag aacgttaaat taaagccttc 2193541 tgtcttctta aaagaatctt ttatactgtt gcgatatgca accatatttg tgacgtcgac 2193601 ttccatcatc gtccaagcat gcggaatttc tgttttgctt cgcttcatat tggaagcaat 2193661 tgcttttctt acacctgtga cagggatttc tttatcaccg gctgcagacg caggatatga 2193721 cgtctcttct tttggctcag gttttgatgc agacttcggt gcaggagctg ctgttttcag 2193781 ctcctcagga ttctgttctt gcacgccgcc tgtttcaatt aagcgctgaa tatcttttcg 2193841 tgtgatgcgc ccgccggcac cagttcctgt cacttgatcg aggtcaatgc cgtgctctcc 2193901 ggccaaacgg agaacagctg gcgagtagcg ctttttattg ggctgatcgg ctgctccagc 2193961 actttttgca acagggttct cagcggcttc tgatgctgct ggctgttctt gtttttgttc 2194021 agccggattc gcgccttctg tttcaatttt gcaaatcatt tctccgactt gcagggtttg 2194081 gccttcttct cccacaagct ctgttatcgt accagtaaaa gaagacggaa cctctgcatt 2194141 taccttatct gtcatgactt ccgcgatcgg atcgtatttg ttcactttat caccgggggc 2194201 gacaagccat ttgctgatcg tcccctctgt tacgctttct ccaagctgcg gcatcgtcat 2194261 ttgttcaatt gccatgattg tatcctccct tacgtcttta aaactccgct aattctctca 2194321 tcgccgcttc cactttatca gggttgacca taaagtattt ttccattgtc ggcgcataag 2194381 gcatagccgg aatatcagga cctgcaagcc gtttgatcgg cgcgtctaag tcgaacagac 2194441 aatgctcgga tataattgcg gctacttcgc tcatgatgct gccttctttt gtatcttctg 2194501 tgaccaaaag aacctttcca gttttggacg cagcttcgat gatggcttct ttatcaagcg 2194561 ggtaaactgt tcttaaatcc accacatgcg ctgaaatgcc atctttttcg agacgttctg 2194621 cagcttgtaa ggcgaagtgg acacacaggc cgtatgtgat cactgtgatg tcgtcgcctt 2194681 ccctttttac gtccgccttg ccgattggca ggacataatc atcagccgga acctcgccct 2194741 ttatcagacg gtatgcccgc ttgtgctcaa aaaacagcac ggggtcttcg tcacgaactg 2194801 cggcttttaa gagccctttc gcgtcatatg gtgttgatgg catgacaatt ttcagtccgg 2194861 gctggttggc gaaaattgct tcgactgatt gagaatgata cagggctccg tgcacgcctc 2194921 cgccgtatgg cgctctgacg acaatcggac agctccagtc attgttgctg cggtagcgga 2194981 ttttagccgc ttcagaaata atttggttga ctgccggcat aatgaaatca gcaaactgca 2195041 tttcagcaat cggtctcatt ccgtacattg ccgctccgat accgactcct gcgattgcag 2195101 attcagcaag cggcgtatcc ataacgcgct cttccccaaa ttgttcatag agtcccgctg 2195161 tcgctttaaa cacaccgcct tttcttccta catcttcccc aaggacgaaa acgcgagaat 2195221 ctcgttccat ttcttctttc atcgccaaat tgattgcatc aatatatgac attactgaca 2195281 tttgttcttc ctccctactt cgcataaaca taatcaagcg ctgactcagg agctgcatat 2195341 ggggcgttct ccgcttcatc cgtcgcttca tttacgattg ccataatttc atccagcatg 2195401 gtttgttcta tctcatcgga cagcaggcct gtttccttta agtaagcttg ataagtaagc 2195461 aggggatcac tttttttcgc ttcctctact tcttcacggc ctctgtagct gctgtcatcg 2195521 tcatcactgg aatgtggtgt aaggcggtaa gaaatcgttt caattaatgt cgggccttct 2195581 cctctgcgtg ccctttcgcg tgcttcttta accgcttgat aaacttccag cggatcattt 2195641 ccattcacag ttacgccagg catcccatag cctatggcac ggtcggaaat gttctcacat 2195701 gcgacttgct tatcgtaagg cactgagatt gcgtatttgt tgttttcaca catgaaaata 2195761 accggcagct tatggacagc ggcaaagttt gccccttcat ggaaatcgcc ttggtttgaa 2195821 gacccttccc cgaatgtaac aaaggctgcg atatcctttt tctccatacg tcccgcaagc 2195881 gcaataccga ctgcgtgcgg cacttgcgtt gtaaccggag atgatcccgt cacaatgcgg 2195941 tttttctttt gtccgaaatg tcccggcatc tggcggcctc ctgagttcgg atctgctgct 2196001 tttgcaaacc cggacatcat taagtccttt gctgtcatgc caaacgcgag cacgacaccc 2196061 atgtctctgt agtacggcaa tacataatcc atttcacggt caagtgcgaa agccgctcct 2196121 acctgtgctg cttcctgtcc ttgacaagag attacaaatg gaattttgcc agaacggttt 2196181 aacagccaca ttctttcatc gatttttctt gctaacagca tggttctata catatcaacg 2196241 gcttcctgat cagtcagccc tagtgcttga tgtcggtttg tactcattca agcccctcct 2196301 ttatgctttt aaaaatgaat ggctttgcca tctgcggcaa gcgcagcttc tccaattgct 2196361 tcagaaagcg ttggatgcgg gtgaatcgtt tgcccgacct cccacggtgt tgcgtccagc 2196421 actttggcaa gacccgcttc agaaatcatg tcggtgacat gcgggccaat catatgaacg 2196481 ccgagaatat catctgtatc tcggtcagcc acgattttga caaaaccgtc gctttcaccg 2196541 tatacaagcg cttttccaat cgccataaat gggaacttgc cgattttgac attatgcccg 2196601 ttcgcctttg cttcgtcttc ggttaagccg acactggcag cttcagggct tgagtaaatg 2196661 cacttcggca caagcgtcgg atcaagcgga tgcggattga gacctgcaaa atgctcaaca 2196721 gcaataattc cctcatgtga agcaacgtga gctaactgca ggccaccgat tacgtctccg 2196781 attgcataaa tatgagattc cttcgtttgg cagctttcat tgactgaaat catgccattt 2196841 tcagtaacaa tatcggtgtt ctctaggccg atgccttcga tatttgcctg tctgccgatg 2196901 gaaacaagca ttttctcagc agaataggta acggtttctc cgtctttttc cgcttgtatg 2196961 ctgatatcgt ctgatgtttt tgtcattgtg tcaggcagca cttttgcccc tgttatgaac 2197021 tggatgcctt ttttcttaag aagactttcc atttcttttg aaatctctag atcttcagtc 2197081 ggcaatatgc gatccgcgta ttcaataacc gttaccttaa cgccaaaatc atgaagcata 2197141 gacgcccatt cgataccgat aacccctccg ccgacaatga tgattgactg tggcagctcc 2197201 tccatttgga gcgcctcatc tgaagtcagt acagacttac cgtccacttc aagacccgga 2197261 agcattctcg gtcttgatcc tgttgcaatg atcacttgtt tcgggatcag catgtcattt 2197321 tcttcgccat ttccccgctc aacagaaatt gttcccggca gcggagagaa gattgacggt 2197381 ccaaggatac gtccatatcc ggtgtacacg tcaatttttc cttttttcat taaatgattt 2197441 acacccgctg caagcttatc aacaacggct tgcttacgct gctgcacttt ttcaaagttg 2197501 agggacacgc cagccgtttc cactccgaat tgatcggctt cacgagctgt ccggtatacc 2197561 tctgcgcttc taagcagcgc tttactcggg atacagcctt tatgcagaca tgttcccccg 2197621 agtttttcct tttccacaac ggctgttttt aagccgagct gagcggctct gatggccgca 2197681 acataaccgc cggtaccgcc gcccagaatg actacgtcat actcagttgc catggtgact 2197741 cactcctgtc tgtctattca atacgatatt gtttggattg ctcttcgccc tgcaatactc 2197801 ttagcgcccc ttgggcaaga gactgcagtt cattttcacc cggataaact aaaacgtctg 2197861 aaatccaatc tatgtatgat ctgatagcag aaacaaagct ttttccgtac gcaaggcctc 2197921 ccgtcagcac aatcgcttca acttcgcctt ttaacgccgc gctggctgcc ccgatttcct 2197981 ttgctacctg atatgccatg gcatcataaa tgaagcgggc tttttcatcg cccccttgaa 2198041 tcatctgttc cacttttact gcatcatttg taccgagata gcctaaaagt ccgccggtgc 2198101 caacaagctt tttcatgatt tcttcttttg tatattcccc tgaaaaacat agatcaacaa 2198161 gatctcccgc aggcactgtt cctgctcgtt caggactgaa tggtccctcg ccgtgcaggc 2198221 cgttattgac atccaccact cgcccgcggt catggacgcc aattgtaata cctccgccca 2198281 tatgggtaat aatcattttc atgttctcat atcgtttgcc aagggaggct gccgctttac 2198341 gagcgacagc tttttggttt aacgcatgga aaatgctttt cctttcaatt tcaggcatgc 2198401 ctgaaacttt cgcaagcact gacatttcgt ctacgacaac agggtcgacg atatacgaag 2198461 ggatattcag gccgtcagcg atttcccgcg cgataatgcc gccgagatta gaagcatgct 2198521 gaccggcgta gccgcttttc aaatcctcaa tcatctcatc attcactacg taggtcccgc 2198581 cttcaattgg ccggagaagg ccgcctcttg cgcagactgc atcaaacttt gaaatattga 2198641 ttccctgttc atgaagcgtt tcgagaatat ggtttttacg aaattcatac tgatcaataa 2198701 ttcggtcaaa tcgctgcagc tcttctatgt tgtgtctcaa tgttttttca aaaatgcttc 2198761 tttcgttatg aaaaacaccg attttcgttg aagttgagcc tggattaatt gtgagaatgc 2198821 gtttttcgtc atgtagcact ttcataacct ccagatcaat ttcttaacgt ctgcttaata 2198881 cactgtggcc gttttgcaaa aactggcttc ttgagcggcg catgcgttca atccgttcct 2198941 ctgctaagcg gtcagccgct aaatatgcag gaatgccgtc acgctgagaa atctcaagta 2199001 cacgctcgat attgccgtaa atgccttcaa cttttttcaa tgcacgttct gcattatagc 2199061 cgtaaagctc atctgccacg ttgatgacac cgcccgcgtt aatcacgtaa tccggtgcat 2199121 aaacgatgcc catttcgtga atttgatcac catggcgtgt ctcttttaat tggttgttag 2199181 ccgcacctgc gatcactttc gccttcagct gtttaatggt gtcgtcgtta atagtcgcac 2199241 caagggcaca cggcgcataa atatcgcagt cttgtgaata aatgtcatca ggatctaccg 2199301 cacgggcgcc aaaatcttca actgcacgct gtacagattg tttgttgata tccgtaacga 2199361 ttaagtttgc tccttcttca tgcaggtggc ggcaaaggtt ataggctacg ttcccaacac 2199421 cctgtacagc aatggttttt ccttcaagag agtcggttcc gaaagcagct ttagctgctg 2199481 ccttcattcc tctgtacacc ccgtacgctg tgactgggga cggatttcca gaagagccga 2199541 aagcaggaga aatccctgtg acatagtctg tctcatcatg aatgatatcc atatcctcga 2199601 ccgttgtgcc cacatcttca gccgtgatgt atctgccatt cagtccttga atatagcggc 2199661 caaacgcgcg gaacatttcc tcatttttgt ctttgcgcgg atcgccgata atgactgttt 2199721 ttccgccgcc aaggtttaag cctgccgccg cgttcttata ggtcatgcct cttgccaatc 2199781 tgagcgcatc ttcaattgcc gcttcttcat tttcatatgt ccacattctc gttccgccaa 2199841 gcgccggacc aagcgttgta tcatgaatgg cgataatcgc ttttaatcca gattgttcat 2199901 cctggcagaa taccaattgt tcgtaatcgt atttctccat atatttaaaa agttccatgt 2199961 tcgttcctcc taatgtgtgt attcttcaga tgcgcatatt gccagcgcaa tggaatacag 2200021 tttattttca gcagagtccg ctctgcttgt taaagcaatc ggtgcttttg ctcctgtaat 2200081 gacagccgcc acgctggcct tggcaaaata aatcagtgat ttatataaaa tattgccggc 2200141 ctcaattgtt gggacgagaa ggatatctgc gttgcccgct acgtctcccg aaattttttt 2200201 ctgggccgcg gcaatttgtg aaactgcgtt atccaaagca agcggtccat caacaatgca 2200261 gcctttgatc tggccccttt tgtacatttg agctagagca gctgcattca cggtcgcttc 2200321 cattttaggg ttcaccgttt cgaccgctgc aagggcagct gcttttggca tattgttccc 2200381 cactgcatgg gccacatgaa cggcattttg caaaatctgc cggagctctt ccagcgaagg 2200441 agcaatattc attgccgaat ctgtcacaaa catcagccgg tcaaaatccg gtatatcgaa 2200501 gacagccacg tgagaaagga cacttgctga ccgaagcccc tcctgtctgt tcaataccgc 2200561 tttaagcaaa acagaagtcg gcacattgcc tttcattaaa acgtccgctg ttttatgatg 2200621 cacagcacga accgctaatt tcgccgattc ctcaggagta ttggcatgga cgatttccac 2200681 ttgatgccct tgcatggatg atgtcagctc gttcagtttt ttgctgtcgc ccgttaacaa 2200741 gaaacgggcg gataggtgct cggctgccag ctttacagcc cggatcactt cctcatcctc 2200801 agcatgagca accgcaatgg tcttattttt gtgtatcgac gctttgccga ttaaatcttt 2200861 cagcttcatc tgttaccacc tttcttgttt cgactccgcc ttttattatg caagttccat 2200921 gccagctctt aagggtgctg tcataccagg tataccgaaa cattcgtgca gatgtttgcg 2200981 tttattctgc aaattattgc atgccttcat ttgcaaggcc atatttatcc attttgtaat 2201041 ataaattccg aatgctgaca ccgagagctt ttgctgtttt tgtccggtta aaatgatgct 2201101 tttcaagcgt ttgctggatc aaatgcgctt caaatttttc tactgcgaca gacagctttt 2201161 cgccttcaat atccggaaaa tcaaaacctg ttccctgatc tgtgtcattt tctttttgct 2201221 caagttcgaa tacaggcaag tgatcttttt caatccattc catatgcgga ttcagaaaaa 2201281 tcatggctcg tccaaggaca ttttcaagct cccggacatt cccaggccaa tggtaggcag 2201341 ataaggcgcg caaggcttgc tgtgagagcc cttttacatt cctgccgtaa tcccggttga 2201401 tcttttggat aagtctgacg ctcaatgctt caatgtcctc caaccgctgc cgcaaaggcg 2201461 ggatggagat cggatagcga ttgatccggt aatacaggtc ttcccggaat gttccgtccg 2201521 ccatcgcctt ttcaatattt acatttgtcg ccgcgatcac tctgacgttg acagggatcg 2201581 ctttcgtgcc gcccactctg acgatttcct tttcttgaag gacgcgtagc aatttggcct 2201641 gcatattttg tgtcagctca ccgatttcat ctaagaaaat actgccgtta tttgcttcct 2201701 caaataaacc ctttttaccg ccgcgcttcg ctcctgaaaa cgcaccatcc tcatagccga 2201761 acaattctga ttcgagcagg ttttcagaaa gggctgcaca attcacgcga ataaatttat 2201821 tgtatttccg gtcactttcg ttatggatgg catgggcgaa cagttctttt cctgttcctg 2201881 attccccgcg cagcaagatg gttgccggtg ttttcgcacc gagcttcgcc tgctcaagcg 2201941 caaccagcat ttgctcgctt ttgccgataa tgtcgtcaaa cgtgtatttc gcttcaagcg 2202001 tgcgaataat ttgtctggcg cgattaagct ccgctgtcag cattttaatt tcggaaacat 2202061 cgtgaatcac gccgacgctg cctttcaaaa tcccgtccac aatcaccggt gctacattaa 2202121 cgatcacttc tttttcattc gggccgacct tcattctgac accgcggaca ggacgtcttg 2202181 tttcaagcac ctttaaatgc atgctttcgc cttcggaaat atcagtgttt gcaggcttgc 2202241 cgatgacttc tttttcagaa agccccgtca ttttcgtata cgctttattg attagcaggc 2202301 cgatgccgtt ttcatcaacg acagaaatcg cctcatcgga ggattgaata attgcctcca 2202361 gcatcgtacg gacctgcttt aagttggtca cttcctctgc cagctcgacc gcatcagtga 2202421 tatctttaaa cacacaaaga gccccgagca gacgtccgcc ttcatcaata atcggcagtc 2202481 ttgtggtcac aatttgcaaa tgatcgccta acagctgctt ctggttgtat tcaggcactc 2202541 ttgtttttaa aatccgcggc atcttagtgc tcggaatcac ttcttttatt gggcgcccaa 2202601 tgacttcctc acgttttttt ccgaccattt tttcggccat atggttaaag agaatgattt 2202661 cttcattgat atcaataaaa atcattccat catgggtgga attaaaaatt ctgtcatatt 2202721 tataggtttg ctcttttagc atttgaatca ggtgctgctt ttcttccatc agctgaaaaa 2202781 cgatgtatgc catttttccc ggcatgacaa tggtatcttc atgctttctt tgaaggagct 2202841 cgtcaaacac ggcttgatcg ccggtagtat gaatgacgat atccggtttt tgttgtatgt 2202901 aaggtttcca atcagatgat acggcaatcc catactgttc tgcttctttc aatcccggcg 2202961 cctcggggtc tttgtcaact acggcaatga tatctatgat ggctgtttta atcagaatat 2203021 gtaataacgc cgttcccctt ttgccggcac ctactatcag taccttttgc atcccgatac 2203081 ccctttgtat gaaaaaattt gcacacctat ttattccgtt gcaataattt gcacaaccct 2203141 atgttaccac gttttcttct cttgacaaaa tattttttcc gctggacaat aaaggaaatg 2203201 aaaagataaa ggggttttct gaagatgagc cgacttcttg cgcttttaat attagtcatc 2203261 cccggggcta tttctgcttt aggcattaaa ctgatgagag atacactttt cggccataca 2203321 atcaagccat tttcagctct ttggctccaa gggttgtcag gattcatctt ttttgcgatc 2203381 ggcctctatg tgctggccgg gttcatttta tacagagaca gaaaacgcaa tcaagtcagc 2203441 ccgcgattca gaaaacgata gctgaaaaaa agccggagaa tgctccggct ttttttgttg 2203501 cattattcgt caggcaaaac ggtcttggca atcgttttgt ctaacgcttc atagtcataa 2203561 taagaaatcg tatcgtacag ttcttttcgt gtctgcatat catgaagtcc ttctttttgt 2203621 gagccgtgct ccttcatcaa accaaacatc cgctcacaag cttttgccgc cgctcgaagc 2203681 gaggtgacag gatatatcac catgtgaaac cccatatctt cgaattcatc ggcacgataa 2203741 tatggcgttt tcccaaattc agtcatattc gcaaggagcg gaacggggat acgctcagca 2203801 aactggcgga attcattctc cgcctgtagc gcttccggga aaattgcgtc cgctcccgcc 2203861 tcaatgtaag cctctgaacg ttttattgcg gcatcaagcc cttcctgcgc cctggcatca 2203921 gtacgggcaa caacaataag ggagggtgcc gcttgtttaa tggcttttat tttttgcgcc 2203981 atttccttta tcggaactag ctgtttgcca tttaaatgtc cgcatttttt tgggagctgc 2204041 tggtcttcca tttgaacggc tgctaccctg gcttcaagca tctcccgggc tgttcgggcg 2204101 gcatttaaga caccgccaaa tcccgtatcg atatccacaa gcaaaggcag atcagctgca 2204161 cgcacaagat ctttggcccg ttcagctatc tctgccgatg tgatgatccc taaatcaggc 2204221 agccccctgc tggctgtata ggcagcaccg gacaaataaa tagcagaaaa accggcttct 2204281 ttcgcaagca aagcggccat cccgtcatgg gcgccgggaa tttgaagaat gtccggtgct 2204341 gacatcagct tgcggaaacg cccggcaagc tcctcttgtg acgattgctt attgacgatc 2204401 cacgacatga aacaaaatcc cccttttaca tgcagaacat gtctacgaat tcatttacgc 2204461 gcatcgtttg taatgtctca tagctggtac agcgctcata aatgtgtttg tgctgtttat 2204521 caggaaaatg ggttttgaga ttgtcagaaa acttttccag cagtttcggc actgcttcct 2204581 ctcttcgaaa acgatggccg aggggaaact cacattccac catttccgtg ctcgttccat 2204641 ctttaaaatg aacctgaacg gcatttgaga tggagcgttt atcaggcttc aaataatcct 2204701 cggtatatgt tttattttca gtcacttcca ttttatcacg aagtttatct attctcggat 2204761 cattcgctgt ttcagcttca taatgctgtg cggtgatatc accaaaaagc aaaccgattg 2204821 ctgtaatgta ttggaggcag tgatcacggt ctgccggatt gtggagcggg ccttttttat 2204881 caatgattcg gatagctgat tcatgcgttc tgatgacaac tcggtcaatc tcgtcaatcc 2204941 ggttctttac ctgcgggtga agaatgacgg cggactccgc cgctgtctgg gcgtgaaatt 2205001 ccgcaggata agacacttta aataacacat tttccatgac ataagcgtcg agcggacggg 2205061 caagcttgat ctctttctta ttgaataaaa cgtcttggaa cccccaaccc ggtgcactca 2205121 aggctgtcgg ataacccatt tcccctttta acgacatcag cgccaaatga acacctctgc 2205181 tcgttgcatc tcctgccgcc catgatttac gcgagcctgt attcggtgaa tggcggtatg 2205241 tcctcaatgc tgcattgtca atccatgcat tcgaaagcgc atttttgatt tcttctcttc 2205301 cgccgcccaa aagctttgct gcaacagcag ttgtcgcaac tttgacaaac agcacatggt 2205361 caaggccaac tcgatttaag ctgttttcta acgccagcac accttggatc tcgtgtgctt 2205421 tgatcatcat ctcaagtacg tcgcgtaccg ttaacggctc ttttccttca gacagcctca 2205481 ctcttgatac ataatcagca gcggcaagga ttcctcccaa gttatcggat ggatgccccc 2205541 actccgccgc cagccacgta tcgttgtaat cgagccagcg aatcatgcag ccaatattaa 2205601 acgctgccct cacaggatcg agaacatatg acgttcccgg cactttgctt ccattcggca 2205661 cagtcgttcc tggaacaatc gggccaagca gctttgtgca ttccggatac cgtagcgcca 2205721 agattccgca gcccagggta tccagcaata catgccccgc tgttgtatac gcttcggcac 2205781 tagtaatctc tttctcaagc acatagtctg tgatttcttc gataacacga tccgttttcg 2205841 gcattctacc agctcctttc atgattttgt ttgatatcgc gggcccatgt aactgacacg 2205901 gggacggaag agccgattat tggcatgctg ttcgatcaca tgggcgcata aaccggacgt 2205961 tctcgcgctg aaaaagatcg gcgtatataa aggaatcggt atgccgagca tccaatacac 2206021 tggggcagca tagtaatcca aattcgggta aagccctttt tccttctcca tcagccgctc 2206081 acccgcttcg cacatctcat ataaacgatg gtcaccggct ttatcgcata attgctgcag 2206141 cgcctctttc atcatgagtg ctctcgggtc catttttttc atatacaccc ggtggccgaa 2206201 gcccatgatt ttttcttttc ttttcagttt tgtttgcaaa agctgctcaa aatcagatgt 2206261 cgtttttgcc tccaaaagca aatacatcac agcttcgttt gctcctccgt gaagattccc 2206321 tttcagggaa gcgacagccc cagtcaaagc cccataaaga tctgaatgtg tagatgcaat 2206381 gaccctggcc gcaaaggttg aattcggcat ctcatgctca ctgtacagga cgagcgaccg 2206441 gtcaaaaatc tgttcttcca atgaagacgg caatttccct gtcatcatgt agagaaaatt 2206501 cgcactgtag gatagggttt gaagcggaag aatcggttct ttcttattaa tgatcctgta 2206561 gctggcagca gtgagggcag gcattttccc aagaagctga taggcgcgtt ctttgtttgc 2206621 ggaaggagac cgatcatcaa tttgccgatc atagccagca agtgccgaca ggccggtacg 2206681 cagaccatcc attggatgag tgtcctcagg gagcagctca agcagacgga gatgatcagc 2206741 aggcaggctt gaggcactgt ttattttacg ttccagcgtt tccatttcac tttcttctgg 2206801 cagcctgccc tccagcaata aatggacaag ctccagatag ctttttgttt cagaaagttc 2206861 tattaaatca tagcctctta tcaaaatctg gctggactgc gtgtcaagat aagaaatatg 2206921 agtttctgcc gcaatcacac cgtccaaccc tggagaataa tgctgtttct cctccatatc 2206981 ctcaacctcc gtttttgcgt tttttgtcta tcaggttccg ccaagcaaat acttggaaat 2207041 aatcagtctt tgaatctcgt tcgtcccttc ataaatttgc gtcacctttg catcgcgaag 2207101 caggcgctca actggataat ccttcatata gccatatccc ccataaattt gaacggcgtc 2207161 taacgccgcc tttacggctg catcggaagc aaattgttta gccatagacg cttcttttcc 2207221 acagtttagg ccgcggttat gaaggtctgc agcgtggtag acaagatgtc ttgccgcctc 2207281 agctctagtc gccatatcag ccagcttaaa tgatatgcct tgattggctg caatcggcct 2207341 tccaaattgc actcgctgct tcgcataatc aacggcatgc tcaagagccg cctctgcaat 2207401 tccgagggcc tgtgccgcaa tgccgatccg gccgacattt aaattcgcca tggcaatgtg 2207461 aaagccatcc ccctctttgc caagcaaatt ggcttcaggc acttctgcat tatcaaaaat 2207521 cagttccgta gtattggagc cataaagccc cagctttctt tctttttttc caacggtaaa 2207581 accgggtgtg tttttttcaa caataaaagc cgaaatcccg tgcctgcctt gatctggagc 2207641 tgttaaagca aatgtgatat agatatcagc tgctccgcca ttcgttatga atattttcga 2207701 tccgtttaat aggtatttgc cgttcttttt gattgctgtt gtgcggaggc tcccggcatc 2207761 cgaccccgag tgaggctccg ttagtgcaaa tgcgcccaaa tggtctcctg acgcgagatt 2207821 tggtatatat ttcatcttct gttcttcgtt gccgaaatac agaatcggat tcgtgccgac 2207881 tgaggtatga acggagagaa tcacgccgac agccgcgctg attctagaaa tctcatgaat 2207941 tgccaaaata taagaaacaa cgtccgctcc agcaccgccg tattgttccg gcaccggtat 2208001 tcccatcagt ccgtgtttac ccattttttt gatcagctga aagggaaatt cgtccgtttt 2208061 ctccatgatt tccgcagcgg gagcaatttc ttttcgtgca aaatcacgca ccatttttcg 2208121 catcatgact tgctcttggg ttacatgcaa ctcggccacc cccggatgga atagacttca 2208181 ggaagtcttc tcctcatagt cataaaaacc gcgtccgctc tttttgccaa gccagcctgc 2208241 tttgacatac ttgcggagca gcgggcaagg acggtatttg gaatcgccaa ggcctgagtg 2208301 aaggacttcc ataattgata aacacgtatc cagtccgata aaatccgcta atgcaagcgg 2208361 acccatcgga tgattcatgc ccagcttcat cacttcatct attgcctccg gcttcgccac 2208421 tccctcatac acgcaataga tggcttcatt aatcattgga agaagcacac ggttggaaac 2208481 aaacccagga aaatcattga cttctaccgc tgttttcccc atcttttccg ctaatgccat 2208541 aacatctaag gccgtttctt ctgatgtagc caagcctcga atcacttcta ccagcttcat 2208601 tacagggacg ggattcataa aatgcatgcc aataacccgt tgaggccggt ttgttacagc 2208661 agcgatttct gtaataggca aggaagatgt attgctggcc aaaatcgtat gaggcgggca 2208721 aatgcgatca agtgttttaa acatctcagt ttttgccgcc atgttttctg cgatagcctc 2208781 aatcacaatg tccgcatgct ctgcctcctc aagtgtttga gaaatcgaaa tgcggttgat 2208841 tacgctcttc acttccgtct cggtcctttt tcctttctca gcatcacggg ccagctgttt 2208901 cttcagccgt ttcaatcctg cctccgcggc ctctggattc acatcataca tccgcacata 2208961 aaagcccgcg tcggcggctg tttgagcaat tccgctcccc atctgacctg cgccagctac 2209021 catgatttgt ttgatttcca ttcaaatccc ctttttcatc atgttttaat gaacctgcac 2209081 taagacggcg tctccctgtg ctgccccgct gcaaatagcg gcaacgccca gaccccctcc 2209141 ccgtcgcttt aattcataaa caagcgtcat gagaattctc gcaccgctcg cgccgatcgg 2209201 gtggccgagc gcgatcgcac cgccattcac atttactttt tcaagatcga aacctacgat 2209261 tttttcacat gtcaaaacaa ctgaagcaaa agcttcattt acttcaaaca agtcaatatc 2209321 ttggacagtt aaaccattct ttttcaggag cttgttaata gcaaaccctg gcgctgccgc 2209381 cagctcgtgc gctggcattc ccgtagttga aaaaccaaga attgtagcca gaggccgttt 2209441 gccaagctca gcagcttttt cctcagacat cagcacgaac gcgccggctc cgtcattgac 2209501 tccaggagca ttgccggctg tgatagaacc gtcacttgca taaatcggag caagttttgc 2209561 gagctgatcc agacttgtgt cacggcgaat cgcttcatct ttatcaacaa cgtttggttt 2209621 tccttttcga ccgatccagt tgacgggaac aatttcatcc tgaaacttcc cttcatcggc 2209681 ggccttagct gcccttgcat gacttctcaa cgcccattcg tcctgctctc ttcgtgagat 2209741 tgcatattcc ttggcagctg tatttccgtg aacagccatg tgcacctcgt caaatgcgca 2209801 cgttaatccg tcatacacca ttaagtccct aagctcgccg tcccccatcc gtgctcccca 2209861 gcgcccggcg ggaacggcat acggaatatt gctcatgctt tccatccccc ccgcaacaag 2209921 tatgtccgca tcctgcgccc gaatcatttg atcacataaa gtgacagcgc gaaggccgga 2209981 agcacagact ttattcagtg tttctgacgg cacactccaa ggcattcccg ccagacgggc 2210041 agcttgacgg gaaggtatct gccctgagcc ggcctggaca accatgccca tgacgtttcc 2210101 ttctacatca tctccagaga ctccagcctg ttgcagcgcc tccttcatca caatgccccc 2210161 aagctcagca gctttcacct ctttcaaaac tccgccgaat ttgccaaatg gagttcttgc 2210221 agcacttaca atgactgttt tcctcatggt ttcacctcat tcagaagata gacagcgctt 2210281 acaatttcta gttgtcttct atgaatgtat gctttgaaac gggcatgaat gaatgaaaaa 2210341 agaaggctgc gtcaaacagc ctccttctaa caactattca tttttcagca atgccgaagc 2210401 cttttctgga aagtcggtaa acatgccgtc tgctcccgct tcaatgagac gcttcatatc 2210461 ttccggacga ttgactgtat acggccttac cttaatcaaa ccgttcctca ttttcttcag 2210521 tacttcatct gtgacccctg ggctgtttat cttcgggtga tagccggaag ccggaataga 2210581 cgcgatatat cgatctgcct gataaagcac atctgaagtt aatactgccc gttcgatatg 2210641 cggtgcaagc cgggcgcaca gcgccaagct gtcatgatta aacgtggata ggatgactct 2210701 gtcctctaca ttaaatcgct tcactgcctc cagcactttt tcttccattc cctcatagcg 2210761 gatcacgctg ttttttaatt caatgttgat gagaaaatcc ttttttaccg cccacgagag 2210821 cacatcttct agcagcggca cttttatatc gctgtacgct tgatcgtgac cagcggccgc 2210881 attcgcagtc tttacctcat cataggctgt atccttcacg aatcctttaa gtgatgtcgt 2210941 gcgattaagt ctttcatcat gaattacaac aatgcgtccg tctttcgtca gctgtacatc 2211001 aagctctatc ccatccgctc cggcttcaat tcctttttca aatgcaagca ttgtattttc 2211061 gggaaattga cctgatgccc cccggtgggc aaaaatcttt gtcatcgttt cacctcaaac 2211121 cctaaagttt tctccattat acttattttg tcggctccac tctaggatta aggctgtatc 2211181 aatctactga tcataataag aatcaatgcc attgacaatc gcatctgcgg ccttttgctg 2211241 gtattcttca cttcccagct tgtccgcgtc agagctgttc gtgataaacc caagctccgc 2211301 caacacactt ggcatttgtg aatatgtaat gacgtaaaag tctgattctt tcacgcccct 2211361 gtctctcgtt tgtaaggaag aaacgagctg tgactgaata tcggatgcca gacgccggct 2211421 gttctcccct tcataatcag attgaaaata cgtttctgtt cctgaagctg aagcaacccc 2211481 tgaattcaca tgaatgctga caaaaaggtc agcctgattg gcacttgcct tagccactct 2211541 ttcctccaag gtcagaaaat gatcgtcaga ccgggatgca acaggattgg ctccctcctc 2211601 ttttagtttg tctgtcacat gctctgagac agccaaatta atatcctttt caaagagccc 2211661 gtttccgacc gctccactgt cttcaccgcc gtgtccggca tcaatataca ctgttttccc 2211721 ttctatcggc tctgctgcct gtgcacaagg cgcgagcgtc aaagccaatc cgcacagcgc 2211781 caagctcctc cataacattc tcaacttact ccctccggtc acgagttctt tcgcagctga 2211841 atatcttcca gctgtaaagt tccattatcc ttctttgtat atttcaccag gacatgtgtc 2211901 tgatctggca gtgattcaca ttcatcacgt ttatccttcg gaacttgtat catggtttct 2211961 tctccattaa gagaaaccgc aatcgtatga ggatcagccg agccaatgta ttttccctct 2212021 tcggtaaacc tcggcactga gtcatccgca cttgcaacac tgcaccccga aagaaagagc 2212081 gcagtaaaca gcaaaagaac cgtttgtttc acatgaccac ctcttcctga tgtttggctt 2212141 ttatctttga ccagaatgga gaatttgtaa agacaacgcg aatgcaggcg agcaagttcc 2212201 atgattttca aaagggctat acgacccgat catttcctgt tgttagaaag ataacgagca 2212261 gatttgtcta tgaggatggc tctaattgag gcgccaatta gaaaaaatta gcggaaagaa 2212321 gcaacttttt attcatttta aaaaatttga gaatagggtg agcaaatcgt ttgacgggtg 2212381 ggtcagccaa gcgtaacctt ttaaaggata tttactttat tgaaagaagt taaagccatg 2212441 aaaaaattcg ttctgctgct ggcggcagct gtcatcacat gctccatcgg ccaccaaatc 2212501 agtggcggct acaaaggccc cgaaaaagag cggccaaaac atcactctgc actcaagata 2212561 ttcagtcggt aaagcagatc aattgcatta atttttacat ataggctaga atatgtgcga 2212621 atccaaacga aagaagatga tcaaatgaat cctaagtata agccactttt tgaaccattt 2212681 acgtttaaaa gcggcgttac aatcaacaac cggatcgcag tagcaccgat gactcattac 2212741 gcttctaatg aagacggtac aatatctgaa gcggagctcg actacatcat cccccgttca 2212801 aaagagatgg gaatggtgat tacagcctgc gcaaatgtta caccggacgg aaaagcattc 2212861 cccgggcagc cggccatcca tgacgattcc aacattccag gtttaaaaaa gttagcacaa 2212921 gccattcagg cacaaggcgc taaagctgtt gtacaaattc atcacggcgg tattgagtgc 2212981 ccgtctgagc tcgttcctca acaggatgtt gtggggccaa gtgacgtgtt tgataacggc 2213041 aaacaaattg ctcgcgcatt aacagaagaa gaagtggaaa acattgtgaa ggcgtttgga 2213101 gaagcgacaa gacgcgccat tgaagccggc tttgacggtg tcgaaattca cggtgcaaac 2213161 ggctacttaa ttcagcagtt ttattctccg aaaaccaacc agcgcacgga tcgctgggga 2213221 ggaagcgatg aaaaacgatt agccttcccg ctcgctattg tcgatgaagt gaaaaaagcc 2213281 gcttcagaac atgcgaaggg tgcattctta gtcggctacc gcctgtctcc ggaagaacct 2213341 gagacaccgg gattgacaat gactgaaact tatacgcttg ttgatgcttt aggggataaa 2213401 gaattggatt atcttcatat ctcactgatg gacgtgaact caaaagcgcg ccgcggtgca 2213461 gatccgactc gcacacgcat ggacttattg aatgaacgtg tcggaaacaa agtgccgctg 2213521 atcgccgtcg gttccatcca ttccgctgat gacgcgcttg ccgtcatcga aaacggtatt 2213581 ccactggtcg ctatgggacg cgaaattcta gttgacccta actggacggt aaaagtaaaa 2213641 gaaggccgtg aaaagcaaat cgaaacagtg atcaaaggca cagataaaga aaaatatcat 2213701 ttgcctgaac cgctatggca agcaattgtg aacacacaag gctgggtgcc ttataaagat 2213761 taatgtgcaa agactgccga aacgattcgg cagtcttttt tccctttata taaatagttt 2213821 gtgtacacat ctaaacagca aaagaaagag ctccccacca acttcgaaaa gaaaatccag 2213881 gaaaaacccc tcacgctttc ttgctttttt ctttttcatt cgtacgtctc ctttttacat 2213941 gaatacgcct tacttacgat tttgcaggag aaaggtttca ttttataacg gacacatcta 2214001 gggtcgatca tgcttcgtga tcctataaga tgtatgaatg gaccaagagt gcaggtaata 2214061 ccgccatttg ctttccttac ttttcaaacc tatcctttac tatatgcgga tacttaatat 2214121 tcttctccca tactacaaat gtccccaaaa caaaacgcct cctatttatc agcgcaaact 2214181 aataaataaa agacgtttga tttaatgacc acttaataag ctcatgttta agaagcctta 2214241 tgctctaacc tcagcttatc cgcaaccatt gcaatgaatt cactgttggt aggtttagct 2214301 tttgtcatgc tgacagtata accaaacaac gaggaaatgg aatcaatgtt tcctctgctc 2214361 catgccactt caattgcatg gcggatcgct ctttctacac ggcttgcggt tgtgttaaat 2214421 tttttggcga tgtccggata gaggactttt gtaatgctgc cgagcaattc gatgtcattg 2214481 tataccattg agattgcttc gcgcagatag agatagcctt taatatgggc tgggacgccg 2214541 atttcatgga taatgcttgt gatgctcgcg tcgagatttt tcttctttgg ttcaggctgg 2214601 ctgctgcgta taatactgct ttgcgatgat ggcgcacgat gcgtcacact gctggcattt 2214661 ccgctgacct ggcggatatg gccgacaagg ttttccatat caaacggttt gagaataaag 2214721 taggacgcgc ctaaatcgac ggcctttttc gtgacatctt cctgcccaaa ggctgtcagc 2214781 ataatgacat tcggctgttt tttcagatct gattccctca gcctctctaa aaccgcaagt 2214841 ccgtctagat gcggcataat aatatctaat acgagcacat cgggatcttt ttctttaaac 2214901 agcgacaggc attcctgtcc gttataagca acgccgatca cttccatgtc ttcctgtcct 2214961 tctatatatt cacttaacag gcttaccagc tctcgattat catcagcaac acaaacttta 2215021 attttctcca cgtttcttcc tccccaaatg tagttaacag gattcaccct tgctacatgt 2215081 ttacattcga caaaaccgct atataccctc taaaaaaatc ataatcacca atattagtgg 2215141 catatctttg ttattctatg tttttctctg tttttcgact aaaaatgaaa tttgacaaac 2215201 aaggaaacgt gaatttgtcg aaaaatcttc ttttgtatat tttaccgtat gtattctgag 2215261 aagtgaagag ggatcaaaat aaaaaaactg ccggaaactc cggcagtcag cttgcttttt 2215321 cttttccata aatatcgatt cctgcttctg acagcatcca ttcaatatga acaccgtagc 2215381 cgcttgtcgg gtcatttaca aatacatggg tgacagcacc gatcactttt ccattttgaa 2215441 tgatcgggct tccgctcatc ccctgtacga tgcctcctgt ttctttcaac agtcttggat 2215501 cggtaatttt caacaccatt ccttttgtcg cagggaattt ttgcggcgtt gtgctgacga 2215561 tttcaatatc gaatttttct actttgtcat catcaataac cgttaaaatt tcagccggcc 2215621 cttttttgac ttcggtagaa aacgcaaccg gcaatgcttg atctgatatg ttgttttgaa 2215681 tcggctgatg cagtgtgccg aaaatcccaa acgggctgtt tctgttaata tccccgatcg 2215741 ttttgcgttc tgaggaaaat cgcgccagtt tttctcccgg attaccgcct gtcccttttt 2215801 caattgatgt tacagtggat ttaacgattt ctccattctc cactacaatt ggtttctttg 2215861 tgtccatatc ggaaatcacg tggccaagtg ctccgtattt ttttgttttc ggttcataaa 2215921 aggtcatagt gccgatgcca gcagcagaat ctctgatata taacccgatt ctgtatttgc 2215981 cttctccttc atccttttct gggatcagct tcgttttgat tttctgttta tcacgtttga 2216041 tcagtaagtc taaagattca ccagttttcc cagccttttg aataaatggg gctacatcat 2216101 tcattttttc aattttctgt ccattcatct caataatgat gtcgcccgct tcaattcctg 2216161 ccgtttctcc cggagatttt ttgccttcac ttgtattgat ttgatgaaat ccgacgacaa 2216221 gaacaccgac ggaatgaagt tttacaccga ttgattgtcc gccaggtata acttttaaat 2216281 caggaagaac atgcactttt gtttttttaa ttggaaatcc ggcaagatca tataccaatt 2216341 ctgactcacc tgattttttg cccgtcacct tgatttcatg cggatctttc tttactgtaa 2216401 acgcttctga ggattctgat gtctgagcgt ttaccgataa actcgtttca atcgcttgtg 2216461 tttgggtttc aaatactctc atttgcgttg gaatcagtaa atattctttt agcggtttgc 2216521 ataaacctac acttaataac gaaacaagga gaattaaacc tactgctttt ctgatgttat 2216581 cgggcattca ctacttcact ctcctcgctc ctatcccaca ccttctttat gacttgctgc 2216641 tacatcattt aattttgcct tctgacggct tatttataac tgtcatatga agaaaaacat 2216701 tggatatact gatgaacgaa tggatgtgca cgaaaaaaat aagctgcgct tctcgcgcag 2216761 cttacccagt tgttttgact tgatccgctt gttttaaaag ttctttcgca tggcgtttcg 2216821 ttaagtcggt tacttcgaca cctgcaatca tgcgcccgat ttccgctacc ttttcctgct 2216881 tagagagcgg cttgacacgt gtcgtcgttc tgccgtcttt taactccttc gcaatataaa 2216941 gatgcgtatc ggccatggca gccacctgag gcaggtgtgt aatgcacagc acttgtgatc 2217001 ctattgacac cttatggatc ttctcagcaa ttgcctgtgc gaccctgccg cttacaccgg 2217061 tatcaacctc gtcaaaaatg atcgatgtca catcctgttg tgaggaaaaa atgcttttta 2217121 tggcaagcat cacccgtgac agctctccac ctgaagcgac tttcgaaagg gatttcagcg 2217181 gctcgcctgt attggttgaa attaaaaact tcaccaggtc aatcccttgt tcagtcagct 2217241 gaacgggctg gccgtttaca agcggcgcct cttcattgcg tgacgctgtt ctgaccttaa 2217301 attccgtatc aaaagttgat ttttccatgt acaggctttt taattcccga tgaatctcat 2217361 cagccagctt tttcgcccat gtttttcgga tttgtgacac atttgccgct tccactgcga 2217421 catctttgcc gacggagtca agctcctttt tcaagctttg aaggtggctg tccctgtttt 2217481 caatttggtc aatctcttct tcaattttag aagcatattc caaaatgtct tcaacagtgg 2217541 caccgtattt tcgtttcagc tgtttgattt cattaagtcg cgtctcaata tagttcaggc 2217601 gttccggatc aaattcaagc tcatccagca tatttctcat ctgaaatgtg gcatcctcaa 2217661 gcaaatagta ggagttcgaa acactttcag acattttttt cagcggttcg tttatatcag 2217721 atatatcttc aagctgcgct gatgccattc caacccagtc caatccgccc tgctcactgc 2217781 gaagcgcgtt atatgcattt tgcagcgact catatatctt ctcaaagttt gaaatttgct 2217841 ggcgctcttc ttggagctgt tcatcttcgt taagctcaag ctttgccgat tcgatttctt 2217901 cgagctgaaa ttgaataaga tcaagacgat gggccatttc ctgttcgctt tcagaaagct 2217961 gcttaagctt tttgagcagc ttcacatacc gctggtaccc ttcctgatac gttttgagcg 2218021 cgctttccac ttcggccccg gcaaacttgt ccaaaagctg gagatgattt tcgtcttcca 2218081 ttaacagctg gttatcgtgc tgcccgtgaa tatctaataa aagcctgccg atctctctta 2218141 gtgaagcaat cgtgacaagc ttgccattga cacggcaaac gcttttcccg ctcgtgctga 2218201 tatcccttct catgacgatc atttcgtctg aaacgtcgat tccctgctca gcgcatacgc 2218261 ctaaaacagg atggccgctc tccaacagaa acagcccttc aagttcggct tttgcttccc 2218321 catatctaac aaattcagat gatccgcggc ctccgactaa aagagaaatg gcatctatga 2218381 tgatggattt gccggctccg gtttctcctg ttaaaaccgt aagcccgcgt tcaaaagaaa 2218441 ccgtcagttc ctcaataatg gcaaagtttt taatcgatag ttcagctaac aaacagcatt 2218501 acacctctta tctttgttag attttctgtt acagcagttc aaggagcctg ttttttacgc 2218561 cttctgtatc ttcaggagtc cggcaaataa ttaaaatcgt atcatctccg caaatggtcc 2218621 ccatcatttc atcccagtcc aaattgtcca tcagcgcccc gattgcctgg gcattgcccg 2218681 gcatcgtttt cagcacaatc atatggcttg ctgagtctat tttcacaaat gcgtccatca 2218741 atgcccgctt tagctttgac agcggattga aacgctggtc cgccggaaga ctgtatttgt 2218801 aagaaccatt atttgtaggc acttttacaa ggtgaagttc tttaatatcc cgtgataccg 2218861 tggcctgcgt tactttgtat ccatcctgct ttagcatgtc gaccaattca tcctgcgttt 2218921 cgatttcatt gcttgtaatg atctctctga ttttaatatg cctctggcct ttgttcatgt 2218981 aagcacctct atttccaagc ttatctgttc ttttatgtta tatgattctc tgcacattgt 2219041 acatgaatgc agaaaaaagg aataatagcg ccctattatt ccggtacatc tgcttttttt 2219101 tcttttaacg tcttatgtgc ttcttctaca acgcgcatga tctcttcttc cggcagttcc 2219161 tggccttcct gtccctctcc cggccaatgc aaatgaagga gaaactcaat atttccgtct 2219221 cctcccgtga ttggagaaaa tgacaagcct ttacagatat agccttcagc ggcagaaaaa 2219281 ctgatcattc gcttgagcac atcagcatgc actttaggat ctctaacaat cccttttttg 2219341 ccgacggatt cccgtcccgc ttcaaactga ggcttaacta aagccatgca gtcgctgccc 2219401 ggtacgagca aagtccttag gacaggcagg atgagccgca gtgaaataaa ggacacatca 2219461 attgtggcaa actccggcat gccctttgta aagtctgccg gtgttgcata acgaaagttc 2219521 gtccgttcca tcacgacgac ccgttcatcc tgtctaagct tccatgcaag ctgattatag 2219581 cctacatcca cagcgtatga ctgtttagct ccattttgca aagcgcagtc cgtaaaaccg 2219641 ccggtggagg agccaatatc aatcataatt ttatctttga cagagacggg aaattccttc 2219701 aacgcttttt cgagctttaa gccgcccctg ctcacatacc tcagcgggtt tcctttgaca 2219761 gttaacggaa ggtcgcggtc aattttttct ccaggcttgt ccaagcggtt ttcgtttgaa 2219821 tagacgatcc ccgccataat ggctcttttg gctttttcac gcgtttccgc cagccctctt 2219881 tccactaata atacatctaa tcgttctttc tttgacgtca tgatccaatt cctttgtgtg 2219941 tctttggtgg catcagtaat ctaatacgat ttgccacctg ctgttttgtc agtccaattt 2220001 cctcaagaag cgctgttaca cttccgtgtt caataaaccg atcaggtata cccattctgt 2220061 caatcggagt atgatattca ccttgatcat gagcgaattc taaaatcgag cttccgaaac 2220121 cgccttctaa gaccgcttct tcaattgtta aaattggcaa gccttctttt aggatactct 2220181 tcatcatctt ttcatcaatc ggcttaataa aacgcgcatt cacaacgcgc acggaaaggc 2220241 cttctttctg cagctcttcg gctgcttcaa tcgccatttc gattgttgtg ccgaatgtta 2220301 agatgacagc atcgttccct ggacgcagca cctcccacgt accgatcgga atcgttttca 2220361 actgttcatc catttttacg ccgagtccgt ttccgcgcgg aaaacgcatt gctatcgggc 2220421 cttcgtcata gctaagtgct gtatgaacca tgtgctggcc ttcattttcg tctttcggca 2220481 tcattaagac catgtttgga atgtggcgca taaacgcaat atcaaacacg ccttgatgtg 2220541 tctctccatc agcgccaacg agtccagcac ggtcaattcc aataaacaca ttagcgtttt 2220601 ggcggcagat gtcatgaaca acttggtcat atgccctttg caggaaggtt gagtaaatcg 2220661 ccaaaaacgg cttcataccc tgcattgcca tagctgcagc cattgttgcg gcatgctgtt 2220721 ctgcgattcc tacgtcgaac atccggtcag ggaattcctt tgcgaagcct tcaagctttg 2220781 aaccgacagg catagccggc gtaatggcta caatgcgtcc gtcctcgcgc gccattcgct 2220841 gcacagttcc gctgacaaga ccgctccacg aaggagctgc ggctttcggc tttacaaagt 2220901 caccggtatt aattttatat ggtccggtac catgccatgt cccaatcgta tcggtctcag 2220961 ccggtttgta ccccttccct tttttcgtaa tgacgtgcag aagaacaggg cctttcgttt 2221021 ttttggcgta ttgaagattc tcaatcagct catgataaga atgtccgtcc actgggccca 2221081 aatacgtaaa accgagctcc tcgaaaaaca ttccggagac gagcatgtat ttcaggctgt 2221141 ctttgacccg ttccgccgtg gcggcaagct tgcccccaac tgccggaatc tttttaaata 2221201 agtattcaag ctcatctttg acccactggt atttccccgc agtgcggagc cgtccgagca 2221261 tagagtgaat ggcaccgacg tttggcgcaa tactcatttc attatcatta aggatgacaa 2221321 tcatgtcttt tttctcgtcg ccgatgtggt taagggcttc gagcgccata ccgccggtca 2221381 gcgcgccgtc accaatgatc ggaataatat attcatccgt tcctttaata tcacgggcag 2221441 ctgccattcc catcgcgcct gacagagaag tcgagctgtg cccggtttcc caaacatcgt 2221501 gctcgctttc actccgcttt ggaaatccgc aaagcccttt gtactggcga agcgtcgcaa 2221561 attcttttcc gcgtcctgtc agcagcttat ggacatacga ctgatggcct acatcccata 2221621 aaaatttgtc tttcgggctg ttaaattcct tatgcagggc aacagtaagc tctacgacac 2221681 ctaagtttgg gccgatgtgg ccgccggaag cggataaact tgtaattaaa aactgacgga 2221741 tttcatcact taatttctct aattcatcaa tggacatgtt ttttaaaaac gacgggtcct 2221801 gtattgataa aagatccaaa gcggatcaac tcactttcag catgaatttc tgcaatgata 2221861 catgtctttt gcatgccgag ctgacaataa tctcagacat aaaaaaagac aaacgcgctt 2221921 ttccttttca tttttcatat aaactgctta cattttacca tacctcgtgc agccgcttca 2221981 aattaggatc gttttagtga tctcttgccg caattaaatc acaaagctca tataaaaggt 2222041 ctttttgaag agagagtccg ccgatcaatc gcttcgcctc ttttatatga acatccaatt 2222101 tatgtttggc cccttccaat gaaagaagcg acgggtatgt cgatttgtca tttgtggtat 2222161 ccgagccgac acgtttgccg attttctctt cactgccttc taaatctaaa atatcgtctc 2222221 tgatttgaaa tccgattcca atgtggctgc tgaaggtacg cagtgtttca atgtcttcct 2222281 caggcgcatc agccaaaata gcaccggcga ttacacaaaa gccaaggagc ttggcagttt 2222341 tccgttcatg aatggattcg agctcttcaa gcgtgacttg tcggttttcc gcttccatat 2222401 cagctacttg cccaccgacc atgccttcgg tgcctgccgc tgaaatcagt tcattcacaa 2222461 gccgcaggcg cttttctgct gacacctcgt ctgacacgtg ggaggtaatc agcttaaagc 2222521 tttctgtgag cagcccgtca cccgctaata ctgccgtcgc ttcaccaaac actttatggt 2222581 ttgtcggctt cccgcggcgc aaatcgtcat catccatgca tggaagatca tcatgaatta 2222641 acgaatacgt gtgaatcatt tcgacagcac agcccaccgg aatgccgtct ttttcgcttt 2222701 ttccatatgc atttaaaaca gccagtacaa tcagaggccg caaccgcttt ccgccggcct 2222761 gtagagaata tagcatagat ttctttaatg agtccggcat atcaagcttt tctgtataga 2222821 cagaaagctg attttcaatt gtttttttcc ggtccgccag aaagctcgtt aatttatttg 2222881 tcaccttcgt cttcctcctg aacactgaaa ggtgccagtt cgccgtcttc ttttaaaatg 2222941 aagtccattt gcttttcgac tttttgcagc ttttcatggc acatttttga cagagccatg 2223001 ccttcttgga aatagttaat ggcttgctct agaggcacat ctccctcttc aagctttgat 2223061 acaatgctct caagcccttt catcgcttct tcaaatgtca tgttttcatt ttttttcacg 2223121 tctgtcattt ttcttcccct ctcttttcta atacttcaca ggtcagcacg ccatccttca 2223181 gcttgatttc aagccggtcc tgctcttcta tttgactgac acttttaatg agtttatctt 2223241 ctttataagc caagctgtat cctctttcca tcacttgaag aggacttagt gcattcagct 2223301 tgccaagaac ggtttgaaat tgggaatgca gctgcttcat ttggatattc atattttttc 2223361 tcagctgatt tgtttgttcc tggtatcgtg ttctcgcttg tttcagctgt tcatgaggat 2223421 gcaatgcctc taatctgtac gtttcacgct ccagctgtct gcttttccga tctaaaagag 2223481 cggtcagctg tgcttgaaac tgctggtacg cgaggtcaaa ctgctgctct ttttgcgcat 2223541 acaaacgctt tggaaaacga aaggcatagg acgattgcag cgtttgtatc cgttcttttt 2223601 tctggccgag atgctgctgc attgctcttg tcattctgac ttccgctgtt tttgtccgtt 2223661 cgattaaatc agtggtatga ggcacagcaa tctcagctgc tcctgtcggc gtcgcagctc 2223721 tgatatcggc gacaaaatca ctaatcgtaa aatccgtctc atgtccgact gccgatataa 2223781 tcggaatatt ggaagcaaag atggcgcgtg ctacaatttc ttcattgaat gcccacagtt 2223841 cttctatcga accgccgcct ctcccgacaa ttaatacgtc gcaaatctct ttttcatttg 2223901 cctcttcaat gcgcgtaacg atggatctgc tcgcattttc accttgtacg agcgctggaa 2223961 gaacaatgac ttttacaagg ggatatcttc tttttagagt tgtaataacg tctctgacag 2224021 cggcacccgt tggagatgtc acaaccccga ttgtggctgg aaatgcgggg atttgttttt 2224081 tgtagcggtc gtcaaataaa ccttctccgg caagcttctt ttttaattct tcgtacgcta 2224141 aataaagcgc tccaaccccg tcaggctgca tttctttggc atataattga tagtttccgc 2224201 tcggttcata tacggaaatt ccgcctctga ccagcacttt cattccgttt tcaggtttaa 2224261 aaggcagacg ctcgctttgt ctcgcgaaca tcaccgactg cattcttgcg ttttcgtctt 2224321 ttaaagtgaa ataaatatgc cctcgtgtgt gtatctttac attcgacaat tcgcctttaa 2224381 tccaaatatt ttcaaggtga ggatctacat cgaattttcg ttttatatac tttgtcagcg 2224441 ctgagacggt cacatacgct gcttcaccca tgtctaaaaa ctcctctcct aagcattcct 2224501 gcaccataac taaagaaaac ccgccctggc tttaggagcc tgaagaagcg ggtatcgtgc 2224561 tcatattcaa ggcgggtaaa catttcgcct gtgaatatct ccaattatct atgataacgt 2224621 acgtttcgca gatttaacag tattatgcgc aagcatcgtg atggtcatcg gacctactcc 2224681 gcccggaacc ggcgttatga aggacgcttt ttcctttgcc ccttcaaatt caacgtctcc 2224741 gcaaagcttt ccgttttcca gacggttaac gccgacgtca atgacaacag cgccctcttt 2224801 gatctggtct gcactgatga agttggctct gccgactgcc accaccagga tgtccgcttt 2224861 tttcgtatgt tcagtaatat tttctgttct tgaatgacag taagtaaccg tcgcgttttc 2224921 atttaataaa agctggccga caggtttgcc gacaatgttg cttcggccga ctacaacaac 2224981 ctctttaccg gaaaggtcaa tattggtttt cttcaaaagc tcaacaattc catgaggcgt 2225041 gcaaggaaga aacgtatctt cgccaagcag cattttccct acgtttaacg gatgaaaacc 2225101 gtctacatct ttatcagggg agatacgttc gatcaccgct ttttcagaaa tatggtctgg 2225161 gagcggaagc tgaacgagaa tgccatgaaa ctcagggtct tggttatatt gatcaataat 2225221 ggaaagcagt tcagcttctg tgaggctgct gtcaaattga tcgagcttga aattcattcc 2225281 cattgtttct gccgcttttt tctttcctcg cacgtaagag tgagaagcag gatcatctcc 2225341 aatcaaaata accgccagtc cgggagtgac gccttgcttt ttaagctctt ctacctcttt 2225401 tgccaattgt tcgcgttttt ctctagccgt ttcttttccg tcgatgattg ttgcagtcat 2225461 tttctttcct cctatgattg ttcaatatca gatttaatgt tagaaagaac cccgtttaca 2225521 aactttgtcg ctttgtcatc accaaaccgt tttgccagct caatcgcttc gttcatggag 2225581 acattcaccg gaatgtcttc ggcatatgcc atttcatatg ctgccaggcg caaaatcgca 2225641 cggtcaacat tggcaatccg atcgagcttc caattcacca gatgcttgga gatcatttca 2225701 tccagctggt cttggtgttc caataccccg tgtacaagct gttcaaagaa aggatctgtt 2225761 ttttcttcat ccagtgcgtg ttctatggct tcattcactg caatatcgct gacatcaatt 2225821 tgaaatagtg cctgcaaagc tttttctctt gctgttcttc ttttcatttt ctttctcctt 2225881 tgatcctctt tatccgcttg tcgttaagcc acaaagagat cataacatat ttttttcgta 2225941 tccgcatatt gaaatcaagg tttttttacc ctattaccga atattttcac acaccttaat 2226001 atgattattc ggatttcacg ttcatgaaga aactcggcta tgtaagccgg ctttcttcat 2226061 gctttgaaat aaagggtaac gtgtaaaaaa accaaagggc cgccctcccc ttggtttcgt 2226121 gttaagccat ttacatttct tcgtcgattt ggacttcttg ggcttttgtg tcaaattgaa 2226181 tgccgacgat gtgaatattg atctcgttaa tcgaaagaga cgtcatattt aataaggttt 2226241 gacgaatgtt ttcctgaacg gatgctgcaa ctttcggaat cgaaacgcca aatgtaacga 2226301 cacagtatac atcgatcgta attccgtcat ccgccaggtc gactttgaca cctttgccat 2226361 gattcacttt gccaaagcgc tcaacgacgc ctgtcgcaaa gtttccgcgc atttcggcaa 2226421 ctccatcaac ttctgatgct gcaatgccgg caatgacctc aatgacctcc ggtgcaatct 2226481 caaccttacc caaatgcgta tcttcgtgat ccattttaag caagctgttg tctttcattc 2226541 aattcacctc cgtaaaaatt atgagcccat tacatcatat gtttctaaaa atttcgtatt 2226601 aaactctccg ctcacaaatg tttcgtgttc aagcagtttt aaatggaaag ggattgttgt 2226661 ctcaatgcct tcgatgacga attcgctcaa tgcgcgcttc atgcgggcaa tcgcttcatc 2226721 tctcgttttt ccgtatgtga ttacctttgc aatcatgctg tcatagtacg gtgggatgga 2226781 atagccaggg tacgcagctg aatcgacacg gacaccaaga ccgccaggag gcaggtacat 2226841 tttaatttca ccaggtgacg gcatgaaatt tttgcttggg ttttctgcgt tgattcggca 2226901 ttcgatggcc cagccttcaa attcaacatc ttcttgcttg aggctcagtt ccattcctga 2226961 agccactttg atttgttcct tgatcaggtc agttcccgtc accatttctg tgactgggtg 2227021 ctccacctgg attctcgtgt tcatttccat gaagtaatag cgctgttcat tgtagtcata 2227081 gataaattca actgttccag cacctgtata gccaaccgct ttggcagcct ttaccgctgc 2227141 atctcccatt tgctccctga tttctgaatc aagggcagga gatggtgatt cttccaaaag 2227201 cttttgcagg cgtctttgga tcgagcagtc gcgttcgccc aaatggatcg tatttccgta 2227261 gttatcagca agcacttgga tctcaacgtg gcgaaaatct tctatgtatt tttcgatgta 2227321 tacacctgga ttcccaaatg cagttgccgc ttcctgctgt gtaatcttaa tgccattaat 2227381 cagttcctct tcagtgcggg caaccctaat tccttttccg cctccgcctg cggtggcttt 2227441 tataattaca ggatacccaa tttcattagc aagcgaaacc gcttcttcca cattttctat 2227501 aattccctgt gaacccggta cgattggcac gccggcctgt ttcatcgttt cccgcgcaac 2227561 gtcttttgtt cccatttttg aaatggcgtc agcgctcggg ccgacaaacg tgacattcac 2227621 ttcttcacat aattcagcga aatcagcatt ttcagctaaa aatccgtatc ccggatgaat 2227681 ggcgtccgtg ccagtcagct ttgcaacact cacaatattt gtaacgttta aatagctgtc 2227741 ttttgatgct ttcggtccga tacaaaaagc ttcatcggcc atttgaacat gaagggcatc 2227801 tttatcagct tctgaataaa cagcgacagt ctcaattccg agctctctgc aggctctgat 2227861 gattctgaca gcaatttctc ctctgttggc gatcaatagc tttttaatca tgttcagtct 2227921 ccttactccg cttttacaag aaatagaggt tgtccgtatt cgaccagctg gccgttttct 2227981 actaatactt caacgatttc gcctttcact tctgcttcga tttcgttgaa aagcttcatc 2228041 gcttctacaa tgcagacaac tgtgttttca tttacttttg aaccggctgt tacatacggg 2228101 ccagcttccg gtgatgaaga agcataaaat gttcctacca ttggtgaagt gattttatgc 2228161 agattctcat cttgctttgg tgcttcttgg gcaggtgccg ctgcttgctg cgcttgcggc 2228221 tgaactgcct gcggagcctg tgcttgtaca ggtgctgccg gtgcctgctg catgacttga 2228281 accgtgcctg cttcgtgttt tttcagtttt aaggatacac cttcattttc atatacgaat 2228341 tcgtcaattg tagactcgtc aattgcttta atcagctcgt ggatttcttt gatatttaac 2228401 attcaatcgc actcctatgt atgaaatttc tttttttata ggttactact aaaagtacat 2228461 actatgttca tcttacagga gcggactttt gaattcaact ctaatatgac agcaacgcaa 2228521 aaagcccgct tgtttagcgg gcttttttcc ctcattctta tttagagggt tcaaatgtga 2228581 cagcgacatc tttcattgtt ttgatttctt ttgccacaag gtctataatg gctgtcgcct 2228641 tcgatttaga gtgtttgtct gatttgactg taatattgat tttatctcct tcagcattaa 2228701 caagcgcatc ctcgtaacct tgtgttttaa tcagcgtttc cagctgtttt tctgttcctt 2228761 ccacttcact gagagccgtc attttatcgt atgcttcgct tttctccttg gctgttgcat 2228821 catcgcttga cacaatggca ttcagctctt ctctttcttt gcttctggca tcttctaaat 2228881 caagacggta cgttgtaaac aaatcatcat cggctgtttc cgtaacaaca gttccttttt 2228941 cactggcttc agcggatgtt tccttgtctg ctgatgaatc tttcgttccc tttgttccat 2229001 cttcttttcc tttttcagtt tctgtaccgc ttttttcctt cgtgtcttgc ttggcaggcg 2229061 ctttttcagt tgcgacctct ccgctgtcag acgcgctttt ttcactttgc atctgcacgg 2229121 cgtttttgct ttccggcgac atgatatagt agacgcttaa caccacgaca agactgagca 2229181 ttgttaatag ccaaacggtt tgttttttaa gcatttatga atcctccttt atttttttag 2229241 gggcaaccgc aacccggtgg cttggaacat ccaggacccg tgtcaccgct tcgataatgg 2229301 tttgttttat ttgaacgttg tccactcctt gagcaacaac gagtacaccg cgtatatcag 2229361 gttttttcgt ttggacgacg acaggtgttt ctttatcgcc gtttttgatc atgacgattt 2229421 cttcctccga tgattggtct gtaacgcttc tttttccgcc ttctttgtca gtttcttcag 2229481 tggttgtatt tttgtttgat ttgttttttt cgtatacttt cagcgacgtt gcatctacat 2229541 tcacgacaac cgagacatcg tccacaccaa tgattgtttc aagaatttct ttcagttgat 2229601 tttcgtattc tttttcatag tcatcgatcg agtctttagg tttatcagat tttgaggctt 2229661 taaacacttc ggctgttttc tctttgctgt ctgcggaatg ttgtgatgat acggccgtta 2229721 tcgttttggc gttttcagtt ttctcaggtg aagaaaacag ctggctgaca agcataaagg 2229781 aaactccgag aacaaaaacg aatagaaagt aatgatattt ggtcagcttc ggcttttcgc 2229841 cgtccttcgt ttgtcccgga agaaactgct ttttcaatac attccataat ccgtttttat 2229901 tcattgccga cactctcccc gccttccata tgaaccgtaa ttttctcact tccgatttcc 2229961 caaatgtccg cgagctgcgt ttgtatctgt ttggcttctt tttgttcggc tgcttctttt 2230021 gttacgtatg catgatctgt atcaatgtgg accggcgcga ccgtttggac cgttttttca 2230081 gaagacgggg ccatatacac gctgattgtt ttaatatcct cttctgaatc taccttttct 2230141 cctgccgtga gtttgatgcg gcctacttta tattcatcat gactgaatct ctcctccgct 2230201 ttctttttta gttggacagc catttcttct agaatatatg cgcgctggga agcttgtatt 2230261 tctatttttt ttgaattgat ttgatttttt atgtcggcag actctgactg cccgtttttt 2230321 gtgaggtatt caaagatgac ttcggggtct gtcttgaaaa gtttaaaaat cggcgtaagc 2230381 atgacgacaa tcaagagcag gctgactacc atttttgcgt acttttgcat gctggagctc 2230441 ggcagcagca tatcaatcac aattgcaaat aggataaaca acacgatggt ggtaagccat 2230501 tccgttaaaa aactcatttg cctgcctcct tcatttcatc atcatcgtga ggtttccggc 2230561 tgtgattatg acagtaaggc ttaaaaaaaa catgagagac acaatggcga gagctgcaaa 2230621 aatataaatg acgcttttgc tgatgacgtc gaggcaggtg atgacgggcc cgcctcctag 2230681 cggctgaaga atcgcggctg ccagcttata aataaaagcg agggaaagca ctttgattgc 2230741 cggaaatgcc gcaatacaga tcaaaatagc gacaccgaga atccctaccg tatttttcag 2230801 cagtaaagag gcgctgatta ctgtatctgt tgcgtctgta aacattcggc caagcacagg 2230861 aataaaattt ccggttataa atttagccgt cctgagcgta atgccgtctg tcactgcagc 2230921 tgacgctccc tgaacagaga tgacgccgag aaagatggta agaaaaacag ccagtgctcc 2230981 gatggcgata tttctgagca ggttagccag ctgcgttact ttgtattgtt cagtcatcgt 2231041 gctgacaatg ctcagaatcg ctgataaaaa aatcagcggc atgacgatat tctgaatcaa 2231101 gagaccgctc gtgttcatca ggaagaggat aacaggatga aagaaggcag cagatacagc 2231161 tccgcctgag gaagccaaaa gcgccaagag gagcggaatg agcgccagga taaagctggt 2231221 catcgtctga atcgcctcag ttgcatagtt aattgccaca tgaaagctat taagcgcaag 2231281 gataatcagc accatgtaca caattgagta agcgacctta ctgacggtgc tttgctgaaa 2231341 agcattttgc aaaagctgca gaatgacgca aaaaatcgtg agcaaaatca atgtgcccag 2231401 cagctttccg ttggcaagca cttcatgaaa caaataagaa aagagagctt tcagccattc 2231461 ttgcggtgag aatgatttat cgccattgat aaactccatt aagctgcctt tttggctttc 2231521 cggcagcagt ccgccgtatt ctgtcataat gtcattccaa aattccccga tcttatctgt 2231581 ttcaagcgag gctgctgtcc tttccgctaa ttgctcggct gtttcagcat ggtcttccgt 2231641 ttgttctgca ttaccagctg cttgtacaat ttctgcacgg cctgctatga tcagcacggc 2231701 caaaagcaaa acccattgaa agcgcttcaa tctaccgcct cctttcggtt atgacataga 2231761 aggtataagt ccgagaatcg tttcgataat gacggttaaa ataggcacag ccattacgag 2231821 tattaaaatt ttccccgcca attctatttt cgaggcgatg gctccttgac cggcatcttt 2231881 tgtgagctgt gccccgaatt cagcaatata ggcgattccg ataatcttta aaatggtttc 2231941 aacatagacc atgttgacat ttgcattaat cgcaattttt tctatcattc gaataatgtc 2232001 gtagatttgg tctaccaaat aaagaaaaat ggcacatccg gcaaaaacga cgattaaaaa 2232061 cgcaaaagtc ggcttttgtt cttttacaat taaagaaagg aaggtggcga tcagccctaa 2232121 acctacaatt tgaacaatgt caatctgcaa gcccccctat ccttggaata aaaacacagc 2232181 ttttatcttt ttaaataggt catctacaat cgtggcgacc ataaataaaa tatagataaa 2232241 acctaacagc gtcacccact gagcatattc tttcttgccc atctgatcca atatcgtgtg 2232301 taaaaaagcg accacgattc ccactccggc gatttgaaat atgacattca cgtctactcc 2232361 cattttattt ttgctcccct cacgtttaca tcaatagaag aatgagtaac aagcccgcta 2232421 aaaagcccaa actttttatc atcttttcgt ttttcgcttg cgcctgctca gcatccgctt 2232481 ctgaggcttc caaatgtgtc agcgccagct tgatgtgctt ttgctgagag attcgatcat 2232541 gaatcccaag cgtctcgcca aactgcttca gcacttcgta ttcgcttttt ttcaaagaca 2232601 gggtgtccca taccttcttt aagctttgct cccacgccgt tttcgcggaa tcacttccct 2232661 tgtccagctg atcactgaat gcggaaaaaa gagttgaaac aggctgtgcg agctgtttgg 2232721 caatctgctg tgaagcagta tgaagcggtg tatggccgta catgatttca gcctcgaggg 2232781 attgaagcgc cgcacgcagc tggcggattt gccgcggccg ttctgtataa atcttcgcca 2232841 tctcaaaacc tgtccatgtt gtcgctacca caatgaatac agcgcccagc agcttcagca 2232901 tgttttcacg cccgtcgtcc tagacagcac atttccgtct ttgtcataaa tttggctcac 2232961 tgtgcccggc ccttttgctc ttgataattc caaatagcgg tcaaaggctc tttcttccca 2233021 caaacgcttc aatgaaggcc gcttcatcag gtcggatata ctccagccat gcgccgatac 2233081 gattactgaa acaccggcat gcagcgcctc cagaagtgca tctgtatctt ccatacgccc 2233141 gatttcatcg acaatcatca cctcagggct catggatcga atcatcatca tcagcccttc 2233201 agcttttgga caggcgtcta acacgtcaat tctctgacca aattgatgct gcggaatacc 2233261 gcgaagacat ccggcaatct ctgaccgttc atcgacgatc cctgtcttta cgggcagcat 2233321 gttttttttg ccggtgcttg agagcctcgc aaggtcccgg agaagtgttg ttttgccggt 2233381 ttggggcggt ccgataatca gcgtattcag ccagctgttt tgatataagt atggaagcag 2233441 cggctccgca atccccagct tttgccgggc aattcgtata ttaaaagatg cgatgtcacg 2233501 gaggcctttc acacctccgt tttccgtaat gactctgccc gccagtccga ctctgtggcc 2233561 gcctctgatc gtgacatacc ctttcttcag ctcttcttca agtgtataca tactatagtt 2233621 gctgagccgg ctcaggatca gatgggcatc ctcggccgtg cccgcatagg acaaataaac 2233681 aggttgtcct cttcgaatca attcaacagg gcggttgatc cgaattctga cttcttcgat 2233741 ttccagccat tgttgttccg gtatttcaga aagggcgttt ttcatggatt cagggagaac 2233801 ctcagcgatt tcattcaaca gagcctcctc ctttctaccg attggcttct ttaaaatgta 2233861 tgatgtgagg cagactttat gacaagcctc tctttattta tgaacacccg ccaaaatcaa 2233921 gacaacaccc gtaaaaatca gaatcagctt tgcatacgaa agctgcccgg caatttggta 2233981 gattccgaca gtcattgtaa tgataaaaat caacggaccg acaatagcga gaatgctgtt 2234041 aaccacaacc gccttccgga catcgttggt cacaagcatg acaattgctg ccgtcagctc 2234101 aatcatagag gataaaactc gtaatcccgc cattgttaaa acagtagaat tgatatttcc 2234161 aagtaaaaat ttcatagcac tctcccaacc tcccattttt ttatatgata tgctctagct 2234221 tgctgaagta gtcttgtcat tttcgtataa aagaaagatt ctgtttttgg gcacaaaaaa 2234281 agcctgctcc catttgggaa cagacttctt tttttctttc tatgctcttg aaacgtaaga 2234341 accgtctgat gtattgacaa caagtgtgtc gccttcattc acaaagaacg gcacgtttac 2234401 aacaagcccg gtttcagttt tcgcaggttt tgtaccgcct gacgctgtat cacctttaat 2234461 accaggttca gtttcaacaa ctttcagctc aactgtgttt ggaagttcga taccaagtgt 2234521 ttcatcctgg tacatcatga tatgcacaga catgttttct agcaggtatt ttaattcttc 2234581 ttcgatttga gttgcgctca gttcaagctg ctcataagaa gaagtatcca taaatacgtg 2234641 ctgatctccg tttgcatata gatattgcat tgttttggtt tcgatttgcg ctttcgctac 2234701 tttttcacca gcgcggaatg ttttttcctg aatcgcgcca gtgcgaaggt tgcggagttt 2234761 agagcggaca aatgccgcac cttttccagg ttttacgtgc tggaagtcaa cgacgcgcca 2234821 aatgccgcca tctacttcaa ttgttaatcc tgtacggaaa tcgttaactg aaatcatgtt 2234881 taatgtcctc ctatattcca atcacaaaat aataagttct tttggggaat gggtgattgt 2234941 ccggttgccg ttttctgtaa tcacgatgtc atcttcaatg cggacaccgc ctgtttctgg 2235001 tatgtaaatg cccggctcca ctgtgaccac catacccggt tcaaggatag ctgaagatct 2235061 gacggataat cccggcgatt catgaacttc catgccgagc ccgtgcccgg ttgaatggcc 2235121 gaaatagtca ccgtagcctt ttgcagcaat atgatccctt gtgagggcgt cagcctcttt 2235181 tcctgtcatt cccggcttaa tatgtgcgac gccaagcgcc tgagcatcaa atacaacctg 2235241 atagatctcc ttcaattgat cactgggctg acctacagcg accgtccggg taatatcaga 2235301 acaatatcct ttataataag cgccaaaatc aagcgtaaca aggtctccgc tttcaatcag 2235361 tttgtcactg gccacaccgt gcggaaggct tgaacgaagg cctgaggcga caatcatatc 2235421 aaaagaagag ctgtctgctc cctggcttct catataaaac tccagctcat tggcaacagc 2235481 gatttcagaa atgccgggtt tcataaacgt caagatatgt ctgaaggcat catctgcaat 2235541 cttcgcagct tcctctaata tcttaatctc ttcactagac ttaatcaagc gcaacttttc 2235601 cacggattca gccacaggca ctaattcggc atcactgata acggcgctgt atgaagcgta 2235661 agtgccatat gtcatgctgt tctgttcaaa gccgagacgc ttgatgccaa acgattcaac 2235721 agtgtcggca gtggtctgaa tcaagctgcc gccatgttca atgatctcaa aaccctttac 2235781 ctgaaccttc gcctgctcag tataacgaaa atccgtaata aacgctgctt tgtcacccga 2235841 tataacagcc aaacccgccg aacctgtaaa ccctgtcata tagcgtacat tagtgttgct 2235901 tgtaatcagc atgccgtcaa ttcccagctg tccaaacagg tttcttaatt tctctagctt 2235961 catcttgatt ctcccccttg ctggcttaat aagtagcgaa cagcaagctt gtagccttca 2236021 gctccaagac cgacaatctg ccctttcgca acaggagcga taaccgactg atgcctgaat 2236081 tcttccctgg cgtataagtt tgataaatgc acctctacca caggaagact gatgcttgaa 2236141 acagcatccc tgatcgcata gctgtaatga ctcagggcgc cggggttcag aacaatcccg 2236201 ctgtattgct cctcagcctc atgtatcgca tctatcaaat caccttcgtg attagactgg 2236261 aagaaagtga gctggatatg taaggcttca gcaaactgaa aaagatctgt ttcaatatcg 2236321 gtcagtgtct ggcggccgaa tacttcaggc tcacgactcc caagccggtt aacattcggt 2236381 ccgttcaaaa tcaaaaaatg aggcacacaa tctctccttt tcgcgagggt ttctcatgta 2236441 aaaaatgttc acttctcgtg aacattttat catactggaa aaggattata cactattctc 2236501 tatgcattcc cagcgcacgt gcaagctttt ccgaattcag ctcattgtat tcaaatgaaa 2236561 tagaataccc gacaaacagc ccgtaaagca aataaatgca aatggtcgta ataattgtat 2236621 ctgatgtcag ttcggtcacc gtgcgcacat ctggaaaaat cggattaaaa acaaaaaaca 2236681 cgagcagcca aagcaccaag ccgtataaaa tacccggcca cattgttttt aaacgtttca 2236741 atagaagaaa ataaagaaat gctgcgccaa ttgaaattac tccaatcaaa atgatgctga 2236801 ttaccgttcc cagcccatgt tttttccact ctccgagtac aaacggctgc aatatcatat 2236861 tcgggctgat ttcggaaaaa tgaaacaaat atgcgatata agcaacgaaa ctccaaagta 2236921 cgcctccgca aaaacctgtt gccgccaccc tgccggccat tgaaacaggc ggcttttgct 2236981 tctcattcaa ttcttcattt tgttctgtat ctttttcgct tgtcatcatg gcacctccag 2237041 ttaaagtgtg cccaaaaaat gaaatgtcaa taaaaaagct cacacttttt ggcagctgcg 2237101 agtaaaattt gaaaataacg ggtataatgc atgtagaaaa agcaaggcta tggcaatttt 2237161 ttcagcctgt caatctagag gtttagcgct gtttcctgta caatagagtg aaaggaaatg 2237221 gttagcaatc ctaaagaaat aggcaggttg ataatatgtc aaaacataaa gttccgcccg 2237281 cttacggcgg gcaggctgtt gtggaaggcg ttatgtttgg cggaaagcat cattacgtta 2237341 cagccatcag aagaacggat ggaagcattg acttttttaa gcttccacgc aaacacaacc 2237401 cgaaactgaa catcgtgaaa aagataccgt ttttacgggg gatcgcggcc attatcgaag 2237461 cgagtgcaaa cggcacaaag catttgaatt tttcaagcga acgttacggg ctcgatccat 2237521 ctgaagacga gacacttgag caggaagaaa aaaaatcctc tgggctgtct atgtatctca 2237581 gcctcgcagt tataggcgtc ctatcatttt tgttcagtaa attcgtattt acattggttc 2237641 cagttttctt agcggaactg acaaggccga ttttttcctt gaacacagcg caaatcgcga 2237701 ttgaaagcct gtttaagttg attttgctgc tcggttacat ctattttttg tccatgacac 2237761 cgcttattaa aagagtgttt caatatcatg gagccgaaca taaagtcata aactgttatg 2237821 aacagaattt gccaattact gtggagaatg tccaaaacca atctcggctt cattaccgct 2237881 gcggatcaag ctttatttta tttacgatta ttgtcggcat gtttgtttat ttactcgttc 2237941 cgacagatcc gctttggctg cgtgttatag atcgtgtcgc actgataccg gtcgtgcttg 2238001 gtatatcctt tgaagttctg cagctgacaa acaaagtgcg tgacattccc ggtctgaaat 2238061 tacttgggta cccgggactt tggcttcagc tgttaaccac aaaggaacct aaggatgaac 2238121 aggttgaagt tgccatcgaa agctttaacg aacttctcag actcgaagca ttgtctgagc 2238181 aaaatcagaa gccttctcac aacgtcatct aaaatccgtt gccctgctat tactttcgga 2238241 ggtggacagt tatgaatcat cgtgtacaac ctattattgc tgtattaatt gcgctgggag 2238301 cgttcggttt cctctatgtg ctggtaacca atcccggaga aatggcaaaa atggcggtaa 2238361 ccgtcatcgt ggcaggtatc attatttatt ttattgtgaa atatgtaatg aatcgaaatg 2238421 cgggcagcga aggagcagcc ttcaaaaaag cggcgaaaca atcacggcgc cggatgaaag 2238481 aacaaaaagc aaaacaccgc gccggacata agggacgtgt cagccacctg cgaagcgttc 2238541 cgagcgccag caagcctaag ccgatgattc tcaagaaaaa aagccagact cagctgactg 2238601 ttatagaagg gaaaaaaaat aaaaagaaaa acagagcgct tttttaatag gtccactgct 2238661 ttaaaaacag ctctgtccgt cttttaccta gctcaatcag ggctagtttt ttttgttgtg 2238721 ttaaatgaaa atcagtggcc attacgtcat caacagggag aaaaatgata ttttgttcat 2238781 agcgtgacgc aatgtgcctt gcgtcatgag catccttcat cgtttcaaac agggcgccga 2238841 acagttcaaa agcgttgcgg atattttttt tcggacgctc tctttcacgc ggcgcaagcg 2238901 tgacaccgat cacagggcgc tttctttcct ttgaaaacag ccagattgga aaattgctta 2238961 acacgcctcc gtcgacaacc gtggcggtgc ctgtgtccgt ttttaatttt atcggttcaa 2239021 agaaatacgg aatgctgcag ctcattctga ccgctctggc aaccgggaac atatctggat 2239081 ttaacccgta acgggccaaa tcgtccggca aaacaatcat ggtgccgttt gtcagatcag 2239141 aagcaataag gcgcagagac cctttctgca aatcgccgaa aacccttatg cctttcgctc 2239201 ttaacagatc agcaatccat ttttctatcg tatcgccttt gtataagcca agacgccagt 2239261 agatggacac ccactggagc atctttaagg ggagaaatga gtacctctga tccagcaatt 2239321 tctctccgtc cacttcttca attaaagcgt ggatttcctt actggtgtaa cctgacgcaa 2239381 tgaaagcggc aataatggcg ccggcgcttg tacccgcaac tcttttaaag cggaagcctt 2239441 tttcctcaag cacttcataa gcgcctgcga gcgcaatgcc ttttactcct ccgccggaaa 2239501 acacaccgtc aatatacatc tcattccctc cccctccatc cgatcgttta ttaccatttt 2239561 aagaaaacac gcgaagaaat agaccaacga atgacgggtg gcgtcagcgt atcaaaaaag 2239621 acggcctcct tcgagaccgc ctttttactg attatgatgt tctgttttct tttggattga 2239681 tttcagatct tttttacggg catcatcttc ttcaaaatat tgaacaagat ccccgatgcg 2239741 atcaatactg ttccagctta aatgatgttc gattccttcg acatcgttat atattttctc 2239801 ttcatcaaca ccaatgattc ttaaaaactg ctcaagcaat tcatgtctgt ataccagccg 2239861 tttgcctatt tttttccctt tagacgttaa cacgagaccg cgatattttt cataaattaa 2239921 atattcgtct ttatctagtt tttgaaccat ttttgttaca gaggagggat ggactgccaa 2239981 tgcttccgcg atatcggaaa ctcgtgcata tcctttttct tcaatcagca tataaatctg 2240041 ttcaatataa tcttccatac ttggtgttgt catcgaaacc ctcccaaaaa gcaccttaac 2240101 tttataaacc attacaagtt tacactaatg aacttgaaaa aacaaggatg ctccgcgggt 2240161 caaaagccct gtttaccgct tataattcca ttcatctgaa gcgtactttg tttcagccaa 2240221 gtgatgaaca aaatcaagct cttcctgaga aagttcatat ggctccaaat gaatgttaag 2240281 acctgtttca aatccttctt taaaggcttt acgagcctca tccatcgtca cccgcttttc 2240341 gatgagttca ttaatggcaa ccgctttatt tttgaaattg cgctgcatcc gctctcttac 2240401 tctttcactt ggatataaga acagatcgaa cagcttgtcc tcatctaaat caagaagaat 2240461 ggagccatgc tgaagaatca cacctttttg tctcgtttgc gcgcttcccg ccaccttgcg 2240521 cccctcaacc actagttcat accacgaagg cgcgtcaaaa caaacagatg accgcggatt 2240581 ttttaagctt tctttttctt tttcagttct cgggatggca aagtaagcgt ccagaccgag 2240641 atttctaaag ccttgaagta tgccttctga aataacccgg taagcctcag taacagtcgc 2240701 cggcatctcg gggtgctctt ccgaaacaat tacgctgtat gtcagttcct gatcgtgcag 2240761 cacacctctc ccgccggtcg ggcgtctgac gaatccgaga ttatatttat gtactgcttc 2240821 aaaattgatt tcctttttaa tattttgaaa ataccctaca gaaagtgtcg ccggattcca 2240881 gccgtaaaaa cggataaccg gggggatttt cttttcgctg tgccaatata aaagcgcttc 2240941 atcaagcgcc atattgaatg caggacttgc attgcctgag tctataaacc gccaagtttc 2241001 tttttgcatt ttaagacctt ccttaccgtt ttaatagaat cagtttatca aactgtcggg 2241061 aaaatgaaaa atattttagt tccattatag atgacaatca cgctgtgctt tactataata 2241121 gtatttgtcg aaaacggctc tatgaccttg ttttatgaag cagggttttg attttatatg 2241181 ctaaaggagt agaatcacat tgtctaatat gatcgttttg attatttttg ctgcatttat 2241241 catctatatg attgcttcat atgtctatca gcagcgaatt atgaaaacac ttaccgaaga 2241301 agaattccgc gcgggttacc gcaaagcgca gcttattgat gttcgtgagc caaatgagtt 2241361 tgagggcgga catattttag gcgcccgcaa catcccgctt tcccagctga aacagagaaa 2241421 aaatgagatc cgtacggaca agcctgttta cctgtactgc caaaacagtg tccgcagcgg 2241481 acgcgcggca caaaccctgc gcaaaaacgg ctgcactgag atttacaacc taaaaggcgg 2241541 ctttaaaaaa tggggcggaa agattaaagc gaagaaataa agcaaacagc tgtctggtag 2241601 acagctgttt ttatttatct ttcttccgcc tcgtatctga gcactgggtg tctcgccgct 2241661 tttgtttcat ccattctttt tacaatcgtt gtatgcgggg cctcctgaac aagctccgga 2241721 ttctcctccg cttcttttgc gatttgaatc atagcatcaa taaacgcgtc cagtgtttcc 2241781 tttgattcgg tctctgtcgg ctcgatcatg atgcattctt caacattaag cgggaaataa 2241841 atcgtcggcg gatgatagcc gaaatcaagg agccgttttg caatatcaag cgtacgcact 2241901 cccagctttt tctgccgctt ccctgataat acaaattcat gcttgcaatg gcggtcaaac 2241961 ggaagatcgt aataaggcgc gagttttctc atcatataat tggcgtttaa cactgcgttc 2242021 tcagtaacag cctttaatcc gtcaggcccc atggagcgaa tatacgtata cgctctcaca 2242081 ttaatgccaa agttgccgta atacggcttc acacggccga tcgcatgagg gcggtcataa 2242141 tcaaacgtaa agcgcccttc ttttttgact aaaactggct ttggcaaata aggaatcaga 2242201 tcttgtttta cgccgacagg gcctgagccg gggcctccgc cgccatgagg gcctgtgaat 2242261 gttttatgca ggttgaggtg caccacgtca aatcccatat caccaggtct cgccttgctt 2242321 aaaacggcat ttaaattagc gccgtcataa tacagtttcc cccccgcttg gtgtacaatt 2242381 tccgccatct ctgtaatctg ctcctcaaac aagccgagcg tgttcggatt cgtcagcata 2242441 agagctgcag tttcttcatt cactgctctt tttaaatcct ctaaatcaac aagccctttt 2242501 tcattcgatt tcaccgtaac ggtttcaaag cctgctactg ttgctgatgc aggattcgtc 2242561 ccatgcgcgg aatcagggac aatgaccttc gtccgcttga aatccccgcg agcttcatga 2242621 taggcacgga tcatcatcag ccccgtccat tcgccgtgcg ctccggcagc aggctgaagc 2242681 gtaacctcat ccattcccgt tatttcttca aggtgtttgc ttaaatcata taaaagctct 2242741 aatgcgcctt gcaccgtgtc ttcatcctga agaggatgaa tcgcagcaaa accaggaata 2242801 cgtgcgattt tttcattgat tttcggatta tatttcatcg tgcaagaacc gagaggataa 2242861 aaaccggaat ccaccccgtg attgcgtttg gacagcgctg tataatggcg catgatgtcc 2242921 agctctgaaa cctccggcag cgctgcgtct tcgtcacgaa tataggtgtc tgacaagagg 2242981 tcccccaatt cgatttccgg tacatcgagc tccggcagac tatagccgat tcggccttct 2243041 cttgaaagtt caaaaataag tgcctggtcc tgattactca tggcgatccc ccaattcctg 2243101 aatgagtgcg tcaatttctt cttttgttct cagctctgtt acagcaatca gcatatggca 2243161 gtccagctct ggatacgtca acccaagatc atatccgcca atcatgcctt ttgccagcaa 2243221 acgcttgttc acagctctca ccggctcatc cagtttgatg acaaattcat taaacatcgg 2243281 cccgtcaaac ataacagtaa ggcctgcttt ttttgcttct tgctttgcat agttggcttt 2243341 taagagattt tggcgggcta tatcttttac gccgtttttt ccgagagcag tcatggccac 2243401 tgatgctgcc agcgcattta aagcttggtt cgagcatata tttgatgttg ctttatcccg 2243461 gcggatatgc tgctccctgg cttgcagggt aagcacaaag cctctttttc cgttttcgtc 2243521 ttccgtttgt ccgacgagac ggcccggcac ctttctcatt aattttttag taacggcaaa 2243581 aaagccgcaa tgcgggccgc cgtatgctga aggaatgccg aaaggctgcg catcaccgac 2243641 gacgatatca gactgaaact tgcccggcgg agtgagaaga cctagcgcca gcgggttggc 2243701 tgaaacaata aacatggatt tcccttgatg agcgataggc tcaatatcct ttagcggctc 2243761 gatcctgccg aaaaaattcg ggtactgaac gatcactgcg gctgtgttct cgcaaacggt 2243821 ttggcgcaat gcatcaagat ccgtaacgcc atccgcagcg ggtacttcaa caacatcaat 2243881 atactgacct tttgcgtaag ttttcagcac ctctcgcgat tcaggatgca cggtttttga 2243941 cacaacaatt tttttctttt tcgtgtggcc tgaagcaagc attgctgctt ctgccaaggc 2244001 tgttccgccg tcatacatcg aggagttggc gatatccatg cctgtcagtt cacagatcat 2244061 cgtttggaat tcaaaaatag cctggagctc tccttgtgaa atctctggct gataaggcgt 2244121 atatgcggta taaaactcag agcgcgaaat gacatgatcc acaatgacag gctgatagtg 2244181 gtcatataca cccgctccta agaaagaagc gtattgtacg gtatcacgat ttttagaggc 2244241 cagctttgtc agttctcttg ttaattctgt ctctgatttc gcttttttga tttgatgctc 2244301 ttttttatat ttgacgtttt ccggtatatc agcaaataaa tcatcgatgc tgcttacgcc 2244361 gatagtagca agcatctcct gtttatcctt ttctgttgcg ggcaaataac ggtgcttcat 2244421 gtgttgtctc ctctctccaa gaaaaaatat tagcgtttat aaaatggtgt tttgacaacc 2244481 tttgctttca ctaatttttt gcgtatctct acatctacaa cagtcccgat ctcactcgtt 2244541 tccgaatcaa ttaaggcaag gccgacgttt tttcctaatg tcggtgactg cgtgccggtt 2244601 gtcacctttc cgacagactt gccattttgg aaaacctcat atccgtgccg cggtatccct 2244661 ttttcaatca tttcgagacc gacaagtttg cgcttcgctc cgttttcttt ttgttcactc 2244721 aatactgact taccgaaaaa gtcagactcc tttttgtgct ttacagcaaa gcctatacct 2244781 gcttcaatcg gtgtaatatc ccgggtcagc tcctgaccgt agagcgggag cttcgcttca 2244841 aaccggagtg tatcacgtgc accgagaccg catggaatca atccgtatgc atcccctgca 2244901 tcgatgattt ttttccaaat atgcatagca tcatcactgc ggcagtaaat ttcatacccg 2244961 tcttctcccg tatagccagt gcgtgaaata agtgctttgc ggccgctgat atcggcttca 2245021 tcaataaacg caaacggctt taatgcagac acatccgcat ctgtcagatt ttttaagatc 2245081 gcttctgctt tcggtccctg tacagccaag agcgcgattt gatctgactg attgtcaatc 2245141 tgcacatcac ctgctgcatg ttctttcatc caagccaagt ctttatctat attagaagca 2245201 ttaatgacaa gcagatagcg gttctctcct ttttgataga taagcaaatc atcgacggtt 2245261 ccgccatccg ggtaacacat cgctgtatat tgagcacggc ctggcgttaa cgcggaaaca 2245321 tcatttgtca tcaatctttg caaaaaagac agactgtcgt tccctgacac ttcgacttct 2245381 cccatatgag atacatcaaa caaaccggct gcagttcgga cagcctcgtg ttcttttttt 2245441 atagaagaaa attgaacagg aagctcccag cctccgaaat caatcgtttt tcctccatat 2245501 tccttataca ggtcaaataa cggcgttctt ttcagcatct aattcctccc ctttatcaac 2245561 ggcgcagcta aaaaacatac aaaaaaggac agagaaacac ctcatgtaaa atgaaggttc 2245621 tctgtcctgg cacctgaaag tttactttgc atacgcaaag acgtcccctt tggtggtttg 2245681 cgcatccgca caaacactct ccagagttgc gtcgagcaag agttcttttg cctgagagat 2245741 tcactccgca gtttgctcct tcggcgcctg tatcccgagg ttttcggtca ggtctctccc 2245801 cttgctgtca ttcgctcata ttttcatgct gttatggaca tactatagca atatcttaca 2245861 tcaaatacat actcatatcc taccatcatc actatatgct gggcaacagc aatttgggca 2245921 gatttttctt atattattca tcttaagaat cgaagaataa gaaaggcggt ttcaaagcaa 2245981 tgaatacaga aatgatctac gatgcaaaat ggcctgaaga atttgctgaa agactgaaaa 2246041 acgatggccc ttgggcaaac tgggaactgt acaagctctc tgcagaaatc cagaaaacat 2246101 tagcaattcc agagtttgaa ggcttacggg ctcctttata tctgccttcc tttacgccgc 2246161 tcccccacca gcttgaagtg gcgcaaaaag tggttgaaaa aatgaacggg aaagcgattt 2246221 tagcagatga ggttggtctc ggaaaaacgg ttgaagctgg actgattcta aaagaatata 2246281 tgattcgcgg gttagcaaaa aaaattttga tccttgtgcc cgcttccctt gtgtcacagt 2246341 gggtcaaaga gcttcaggaa aaatttttga ttccggctgt tgaacaaaag aaaagctatg 2246401 tgtgggagca atgcgatatt gtcgtctcat caatagacac cgcgaagcgc tcgccccatc 2246461 gagaaatcgt tctgtctatc ccatatgatc ttgtcattat tgatgaggca cacaaactga 2246521 aaaatagcaa aacgaagaac tatgaatttg tccggaatct cgtaaaaaaa tattgcctgc 2246581 ttcttaccgc gacgccaatc cagaaccgta tcgaagagat tttcaatttg gtgtccttat 2246641 taaaacccgg ccatttaggc agtcagaatc actttcagga ggagttcgcc aagaagaaat 2246701 ccagtttaga agcgcatgaa catttaaaag atcttgtgaa taaagtcatg atccgtaaca 2246761 ggcggcatga tacagggctg aattggaaac agcgccatgt tgaaacagtg ccgattcaat 2246821 tttctccatc agagcaggcg ctttatgatg aaatttctcg tttgaaggac agtatcaata 2246881 aaccagccag catgttctcg attatgacct tgcaaagaga atgctgttcg agcagagaag 2246941 cggtatatat gacgctgaaa aagatgcttg atcaaaaaga gaaacaagca cctgccattg 2247001 atgaggatac gatttcagtt ttgatagatc gcatcaatca agtgacacaa aactctaaag 2247061 cgcttcaagt tgttgacttg atcaaaaaga tcgacgataa ggtcatcatt tttacagaat 2247121 accgcgcaac ccagatttat ctgcagtggt ttcttcagca aaacggcatc agttctgtgc 2247181 cgtttagagg cggatttaaa cgtggaaaaa aagactggat gaaggatctt ttccgcggaa 2247241 aaatccaagt ccttattgca actgaagcag gcggtgaggg aattaacctg caattttgca 2247301 atcacatgat caactatgac ctgccatgga acccgatgcg gcttgagcaa agaatcggaa 2247361 gaattcacag actcgggcag gagcgtgacg tgcatattta taacatggcg acaaaacata 2247421 cggtggaaga gcatattcta aagcttttat atgaaaaaat tcatttgttt gaaaaagtgg 2247481 tcggtgaact tgatgatatt ttaacgaaaa ttcaagtgaa caattttgaa gagcaccttc 2247541 atgacatttt gtatcactca gcaacagaag aagaaatgaa aataaaaatg gataacttaa 2247601 cctcattttt gtcttataaa aaacagctgc ctgctgaaaa aagaggatct tagcctgtaa 2247661 ggaggtttta ttagtgagac agcaagaggt tcacgatttt ctgctgcgtt tttttcaagc 2247721 aaacagctgc caaatcgtcg atcaaggctt aggctatatg acagtgcagc ttacagttga 2247781 aatggacaaa caaatcatga accgcccttt ctactggcat tggcgcgaga agacaggcgg 2247841 tgatccgaat ccaatgaaaa tcacttttat tacagataaa gaaaatgcgc caaaagacct 2247901 agatggtgaa tttatatatt ttggggcccc gcgtcttttt caaatattca aagctgttaa 2247961 acaaaatggg agatttacca gaatgtatga gaaaattgaa tcagccggag ctaaagtccc 2248021 acttcagcct tggcttggta taaatgtcac gatttcatac cagtccgaca tgaaaaagga 2248081 taagttattg tcactaggtc ttcacctagt ctctggaacg ataattgaag attttcaaag 2248141 caagctgacc cagttttcac tgacgtctca aatatgtgac tattgcttca ccatttcacc 2248201 tatgatcaaa ccagaaagcg gacttaagcg tatggaaaac tatatttcca aatccgctat 2248261 gcaggagccg tccgactggg cggaacaggc ggttaacagg tggaagaatg atatgacatt 2248321 gcttgataag ttttacgagc atatagaaga aaaaccagaa gaataccatc tagaaaaaca 2248381 ggcgctgaaa accttgtatc aaccaaagat atcagttgaa attgaaaatg gcggattgtt 2248441 ttatctgcaa aataatattt caagctaact tttttaccat tcgacatcat tctcgttttt 2248501 tttgagaaaa tacgattata ataaaggtat attggaaaaa aattctggtg atttaatggc 2248561 aaatgacttc cagagactaa tgaagcatac aataagtcat ggccggactg gctgaaatac 2248621 ataaacaagt attttaggag gagaaactgc atgaagaatg caaaacaaga gcactttgaa 2248681 ttggatcaag aatgggttga attaatggtg gaagccaaag aggcaaatat cagcccggaa 2248741 gaaatacgaa aatatttact tttaaacaaa aagtctgctc atcctggtcc ggcagccaga 2248801 agtcataccg taaatccttt ctgaatgtgc tataatatca caaggaaggt gatgacattg 2248861 attggccagc gtattaaaca ataccgtaaa gaaaaaggct actcactatc agaactagct 2248921 gaaaaagctg gggtagcgaa gtcttattta agctcaatag aacgaaatct acaaacgaac 2248981 ccctccattc aatttctcga aaaagtctcc gctgttctgg acgtctcggt tcatactttg 2249041 ctcgatgaga aacatgaaac cgaatacgat ggtcaattag atagtgaatg ggagaaattg 2249101 gttcgcgatg cgatgacatc cggggtatcg aaaaaacaat ttcgtgaatt tttagattat 2249161 caaaaatgga gaaaatccca aaaagaggag tagtgcctga gcagaggcac taactcctct 2249221 tttgtcaata accatcgaga cggcccagta tatgaatact gggccgtctc ttttttttgc 2249281 tgttattaat ttttatcctc gctatgcgct ttttcatttt ctttcacgta accatcttta 2249341 tcagtatggt cctttttgat tgtcaagccg ttccactgtg tagcttcgaa tgagaattga 2249401 agcttaatgg agttgccttg atatttattt tgaaccataa gccctttttc atcttttgtt 2249461 ttatcatcct tgaattggat ttccatttga acctgatcga agtcagttgg tgtttttgga 2249521 acaccatcat attcaggagc ggttttacca tcaattgttg ctacattgac tttaccgctt 2249581 gcatttaaga atttagggtc aatttgtttt ttgatttttt cagcagccgc tgcatcattt 2249641 ttagcagaca tcaaatacaa gtctttaagg ttcgcatcat ctaaaataat gtttttcggg 2249701 tagccattgc cgccctcttt tccaactgtc aacaatgtca cttcaaactg gctgaggaaa 2249761 tcttctggag atgtattgct gccgccgttt gctttaaaat ctccataatt aagcgccatt 2249821 agaacttctt tgatcgcaag tgatccgtta ttttcaaatt ggaaatcctt tgtcaactta 2249881 tctcccggct ttagatttga taagttcaca ctcgctgaat tctctttagc agataaatca 2249941 agcgtacctg atgcaaaagt agcatccttt gatttaatgt cgttaaatgc tgcccatgtt 2250001 cctcctccaa ctaaagctaa tcctagtgct gcagaagcaa ctcctaaact caatttcttt 2250061 ttcataccca tggtaagctc cccttttatt gaatgatttt atatcgaaac ctgttgccag 2250121 gtttacaact gaagttaagt agacatggtg ctgtcctttg tatctgtttc caaggctttt 2250181 gtctttcttt caatttctct aatggcgctg ctgatcgtca caaaagcgta aactaacagc 2250241 atcacgccgg gaacaatcaa taatacagcc gttccaatcg gctggctggc aaaatgaagc 2250301 atatagccgg catatggaag ctgaaaacct gtgtattgcg cgcgaacatt ttcgtccgat 2250361 acaggcgctg aatcagctgc tgcattatta tcaccttttg ttttaaataa caaatggtct 2250421 ccttgctttg ttatgtcaac aattctgtgg gtgaccgccg tatttgcatc ctgcataaat 2250481 gtaataacgt cacctttttg gagctctttc acatcagtga tttctttgac caatattaag 2250541 gaacctgtat tgaactccgg ctccatcgaa cctgacagaa ctgatttcag cgtataccca 2250601 aacactgccg gctctccccc ggatgaacgt gttgaaatca cgacaagtgt cagcacaata 2250661 ataagagtaa agatgatcac gtataaaata ttactgatca gcttcattgc ttttttcatc 2250721 ctcttccccg ctttccttct ggtctgattg agtttctttt tctttggtta cagcttcttg 2250781 agatgtttct tctttcattg ttttttccgg tatatctttt tgtgttgttt cattctcctt 2250841 tttgacgtcc gactttgttt cttttttagg gactgtcggt ttttcatcgc attttgcaag 2250901 cctcataggc tccgaccact caaatgtact gccgtttgcc gggtagcctg ccggtttata 2250961 tactttaaat gcataaatgc cgggtttcat ttttttcttg gtctcaattt tataaagtga 2251021 atcgccgatt tgattggaga caaatccttt ttcgatcacg ttcccatcct ttaacggttt 2251081 gcgggcattt tcaagcttat gaagctccca cttccacttt gatttcttaa gtttctcacc 2251141 tgtattttcg agcacagcaa ataaggcgaa aggtgagcat acagtgcctt tcgtatccgt 2251201 ttgatctgat atgtgcaaat cactttgatc ccagcgttta tcataatggc agtttttatc 2251261 tgtatgctga aagtctttac acgtttgaag tgagacatca aatgtttcaa tatcatgaaa 2251321 agcagcgctt gtatcatcgg aaaattgtaa gcatattgcg gcagtcagac tgaaaatgac 2251381 tgaaagctga aagataagca gaactttcag tttcgtcttc gccttttgct gattgtgaaa 2251441 caatcgaaac atatcttacc tcctgtaaaa cactgtaact tgatatgaca atcgttctct 2251501 ttaaagaact tcacaaatag agtataatca acgatttata gatttaaaaa caccgaaatc 2251561 gctcattttg ttcgtttaaa agaatgtttt catcatatta caaagtcttg ctcagtattg 2251621 ctcatttttt caatttttta gaaatttttg ggattgttat gtgagaattt aaatgcatat 2251681 cccattatta tttggtaata ataaacaaag aaagggtgac agcatgatga tcaaacaatg 2251741 tgtgatttgt ctatctcttc tcgtctttgg caccacagcc gctcacgcag aagaaacacc 2251801 gcttgtaacc gcccgccaca tgtccaaatg ggaagagatt gctgtaaaag aagcaaaaaa 2251861 aaggtacccg ctcgcacagg tactgttcaa acaaaaagta tgggaccgta aaagaaaaga 2251921 tgaagcagtg aagcaatacc atttaactct gagggaaggg tcaaaagaat tcggcgtttt 2251981 tgtgacgatt tcatttgatc cttatagcca aaaggtcaat aaaattgcca tattagaaga 2252041 atatcaataa ggtcctccat tttttgaagg accttattcg tttatttgcg gttatttttt 2252101 ccgtttcagc caaagtcgga agccataggg taaaataccg aaccactgct gggaaacagg 2252161 cgtttttgtt tctttccgca cctcttttcg ttcttttcgc tcatctctcg gagtatctat 2252221 atatttgaca aattgctgcg tcatatattt aacataatca ttcgttttca cgtgatcacc 2252281 tcatcattca attattatga gtgttgtctc acatgacttt ttttataccc tttacactgt 2252341 tttattctgt ccatctcagc agttttttct gtttttggtc aaacacgatc tgtgcagttc 2252401 tttctgttcc cgaatccgtt gacactctta agttgatttc tttttgttct tttatcgatg 2252461 tatcatgaat gtaataagaa acccgtccat atagaaattg ctgcgtaccc tcctggcctt 2252521 tccgttcctc tagaacatgc cgaatcgaaa gaagcacccc attttgaagc aaattctctc 2252581 ctatgtataa ctcttttgtt tccttctcaa acatgcagcg tgaaatatat tgagcagcaa 2252641 caaagttcac gattaacagc acaagcgctg acacaaaaag aacagctgga taaataaacc 2252701 ctcttgtacg atacattcac ccccctccta aatacgaata gactggaaaa gcagtttgat 2252761 acactttttg gtcttcactc tcaattttca gcaaaacaac accattttca atatcagctt 2252821 tcatggcagt aatatgatct aaaatcggaa catgcccttt gccatccact ctttttctta 2252881 tcattgaatg ataaatgtca aaacggatgt cttgtccgga aagattggtg cagattaaca 2252941 cgctcccatg ctcggctgtc ttaactgcct gtgattcctt gcattcattc atcatctgtt 2253001 ctatcgaaat catccattcc tgctgtgtga aaccgtcatg ttcctgctgt cgagacaaaa 2253061 acagatggat aatcgcagct aacgatcctg atatgagcaa aaagactgag agcgaaaata 2253121 atacgttaag aagcgtgtag ccattctgtc tgcaaaatgc tgaggcaaaa tgatttttct 2253181 ttataagctg cggctttgat acatacgttt tgatattcgc cctcctcctc ccacttcatt 2253241 gcatagatat gattgttctt tgtaatcgtt tttgacgcgg ctccttcacc actcatgaca 2253301 tatttgctaa tgctctcatt catcatctga tagccaattt ctcgtgattc cgccattttt 2253361 tcatcagcca tcagcttgtc ccacaagggg acgactgtca gcagcacaaa cagccacagg 2253421 cttagcgcag acattgtttc tattgtagaa aaacctttat tttctctcca cattgactct 2253481 cccgctccct agataaactg ttatgtcata aacggcatgg ccttttactc gtatttttcc 2253541 gcctgcattc gggtgccctt tctcattaaa ttccaaacgg tcttttaatg tcagcagttc 2253601 tatagaaagt cccgttgcat acggacgttc aataaccgta tcaccaatga ctaattgata 2253661 ttctttttta tgaaagagaa tttttgttct ttgttgacgg gaaatagcag tctgctgtgt 2253721 gagcataata tcatttttca gctgacttgc tgcctgtcgg acagctgtat tgtcataagc 2253781 aggaggaagt gtagtgaaga cggccaccag gaggatagag gcaaggctta acacaagcaa 2253841 actttctaaa agggtaaacc ccttctcctc gtttaattta atgttcaacc ttaacttctc 2253901 cgccggtgat gataatgcgc ttaccatttg gacagacagc atcctttttc acatagccct 2253961 ctgactgtaa atcggcaagg ctcggagttt gtccttcatg atcaagctca aatgcagtca 2254021 tttgtgcctt aaccatgttt tgtaagcctt cacagccctt tttttgaatg gtttgattat 2254081 gtttcgtgac gttcggtatc gtaattaaaa gcaaaatcga aataataaag agcacgatta 2254141 acatttcaac aagtgtaaat cctttctcat tcatcagcct cttcctttca catttgattc 2254201 atcatctgat acataggcac aagcatagat aaatacacaa gtaagatcat cgctgcaaca 2254261 aatccataaa tcattggctg aaggatgcct gtccattttt gcgctttgtg ttccagccgc 2254321 tgtaatatga attggctgta tgtgaaaagc tcccgatcca atcggccgct cagctggccg 2254381 tgagatatga cttttgataa atcagtttca taaaaaaggc ttccacaaat agcggattca 2254441 attgactcac cggcttttag ccgttcaatc aattgttcag cctcgcagcg gtagaaaggg 2254501 agaaacgttt gatgtttaaa tgcattaagg ctgtcataaa ttgagaggcc tgattttaaa 2254561 aggctgctta gctgcaaaga aaaaaagtag ctgttaaaca gctttacaag ctttccaacc 2254621 aaaggaatcc tgatacaaat cagcatttgc cgggcaggtg attttttctt aaacacaagc 2254681 caataataaa tcccgatacc tgctgtaaaa agaacaagca aaatgatcac aagatcaata 2254741 tgctgaaaaa aagcaaaaag catatcggtt gaacgtgagg tttccatatt catcgattga 2254801 tagataccgg aaaactgagg aatgatgatg gactgtaaca tataaaacat gacagcgacc 2254861 gtaaagatga ggaaaagcgg atagcgcagc actcttttca gctggtctgc ctgtgcaatt 2254921 tttcgttcca gcagctctcc gctctggatc attgaagcag gcagttcacc atgtgtttca 2254981 gcaaaataac aaatacctac ggcttcctta tgaaatgaca aactctttag tacttgataa 2255041 aacggagccc cttccctcaa acaagtgacc gaatcagtca agtcagccgc ctgcctctta 2255101 ttcatctgaa gttccatcag gcgtaatcca tccagaagtg tatatccgcc cgcagtcatt 2255161 tcaccgagcc tctttaataa cctggcttga tcctttaaca accagacttt tctaatcttt 2255221 ttcatgataa acccaccggt catagttgtt tgtcgttaaa tagccgagcg caattccttt 2255281 tctgataatt tgacgaagcg tttgatattg gtaatttgca tgatttcctt ttgcctcctg 2255341 gatacattgc tgaagatttt tcccgtatag aagctcataa acgctagctc tcctagtatt 2255401 tcgtgactgt cggcaataca ctgatgaaca tccgttttca caaaacgggc aagccaaatc 2255461 aaccaagcgc tgagccgcta ttgcaatgac agtctgttcg atttcattca tattgatacc 2255521 gaattcaagc agtctgtaaa ttgcgccctt tgcgtctctc gtatgaaggc tcgttagtac 2255581 cagatgtccc gtcatcgctg cccgcaccgc aatttcagct gtttccgcgt ctctgatctc 2255641 acctaaaata atcatatcgg ggtcatggcg caaaattgct ttcagacctg cggaataagt 2255701 tacaccggct ttttcattca cctgaacctg aagaacatct tcgtcccttg tttcaacagg 2255761 gtcctctaat gtgacaatat ttcgattaaa gtgttttttt gcatattgaa cgagagagta 2255821 taatgtggta gtcttccctg aaccagtcgg cccggtaaaa atgagcatgc catgggaatg 2255881 ttttaaaaac gagagtaatg tggctcctgt cttcggaaat agcgacaatt tatcaatcga 2255941 agggatattg tattggggca tcactctgat cacgaggctt tcttcattaa ttgtgggcag 2256001 cgttgacatt cttaaatgaa catttccctc tttcaacttt aacgtaagcg aaccgttttg 2256061 cggctttcgc ctttcaccta tatccattgc tgaaagaaat ttaaaatgtg aaatcagtct 2256121 tacgcactct tcttttttca tgtccctttt tttcagcaag gcatgatcga cccgaaaatg 2256181 aatgatagcg tcccgctccc tcggcacaat gtgaatatca gaagcctttg ttagatatgc 2256241 ctcttcaatc aagtttttgc ttaccttttc tattgaatcc aatttgattc cctctccttt 2256301 caacgcatat tgtagaaaaa gaagaaaagg taatcaaaca gggaaaacgt gattttgtga 2256361 gatgttatat gctgaaaaac caattctttc tggcaagaaa aaagactttc aactgaatgt 2256421 acccctgtca ttataatttt ccctataaat aaaaaagcag acatggtcac catgcctgct 2256481 agattccatt ttcattatgc tgttttcgct tattgaccag tatctttctc aacggaaaga 2256541 tcgcctaatg caacaatacc ggtcatttgg tcattttcaa gaatcgataa actgcggatt 2256601 taatgctctg tcataagccc cttgacatcg tatccggtca ccctgatatg tctggtgaaa 2256661 aagcggggca cgctgcacaa aatatgaaac atcctataga gtccgccttt ttcgaggttt 2256721 ctttttcttc ttccgctcct gcagcatatc tcccgtccag cctttttttc tcaaatagag 2256781 atagatcaga actgtagatg tgacaatcaa taagagggaa aagagatatc cgtatttcca 2256841 attcagttcc ggcatcactg aaaagttcat cccccataag gcacccagag ctgtaatcgg 2256901 agtaaaaagc gtcgtgaaaa tggtcagcgc ttttacaatt tcattccccc tatgtgaggt 2256961 aatgacttcc tctgaatgca gcagattgtt aagctcccct tcaaattcgc tgatgtatgt 2257021 aaatcccctg tcaatcttca gttgtgtccg ctgataatcc tttttccctt cattttgagg 2257081 taaaaaggtt tctttcaacg ccatttcaat ttttttagcg cttaatatca aatttttcca 2257141 aatcatcagt tcatggcgca ggagatggac gcggtttaaa atgcttttgc tattgtcgtc 2257201 tttaatttgc catctgagct ttctcagctt gacttcaaat tcatcaacac cgattaaata 2257261 cgcattcatt agttcgccga gaagaattaa aaacccctct atcgcattgt ccgctctttc 2257321 catttgccga acaacttctt tgcctttaat ctctctcaaa attgaaaagt caaagttgat 2257381 tgtaaaaaaa tattgtctgg tgatataaaa gtgaaaaaca gtatggtctt tttcttcacc 2257441 aagcccctga tcataaacaa tcgacccaaa tactgcttca ttttccgttt cagttgtatc 2257501 tactcgcaaa aaattaacgt gatggttatt ttcaaaccac ttttcacact gaggccagtg 2257561 agaaaaatgg attagatctc ttgccttact tctttcttga ggccccattt ggtaccaaaa 2257621 ccaatccttt cccgtatgtg ccttcatgtc aagctcctcc aaacttttgt tctttattct 2257681 ttaattgccc aataaccgcg tcactaaacc agtctgccgc ttcaacacat gttttatgag 2257741 cattttcagg tggtatggaa tgtagaaaga catcggaaaa gggaggtgca tgccttcctt 2257801 ggagaaggca gttgttttgg aatttatcaa tttactagca gtcgctattc tcattttgtt 2257861 aacaggattt ttcgttgccg tagaattttc aatcgtaaaa gtgcggcgat ccaaaattga 2257921 tcagcttgtc gcaaaaggaa agaaaggtgc taaagcggca aagcatgtca tcactcacct 2257981 tgatgaatat ttatcagcct gtcagctggg catcacagtc gcagctttag gactgggatg 2258041 gcttggggaa ccgactgtgc aaactctgct tcgaccgctt tttcataaag caggcttaaa 2258101 tgaatcgctt acccacctgc tttcactcgt catcgcattt ttagtggtta cgtatttaaa 2258161 tgtcgttatt ggggagctgg cgccaaagag tttcgccatt caaaaagcag aaagcattac 2258221 cttgttgttc gctaaaccgc ttatttggtt ttataagatc atgtttccat tcatttggct 2258281 gttgaaccac tctgcccgat tgattacagg agtgtttggg ctgaagccgg catcagagca 2258341 tgagctggct tatacagagg aagaacttcg ggtcctattg gctgaaagct ataaaagcgg 2258401 cgagatcaga aaaagtgaat taaagtacat gaataatatc ttcacctttg ataaacgaat 2258461 ggcaaaggaa attatggtgc cgcgaaatga aatggttagt ttgtcactag atgaagactc 2258521 catttcaaat cttcaggaaa cagtcaagca aacaaaatat acacggtacc cggttgtaag 2258581 agaggataaa gataacgtca ttggcgtgat taatatgaaa gaagtgctgt tttccatgct 2258641 gacgaaagat ttttcaatca agaagcatca aattgaacct ttcgtacagc ccgttatcca 2258701 tgtaattgag acgattccta tttataaact attgctgaaa atgcaaaagg aacgcactca 2258761 tatggcgatc ctcatagatg aatatggcgg gacgtccggt ttggtcactg tcgaggatat 2258821 tatcgaagaa attgtaggag aaatccgtga tgaatttgat gcggatgaag tgcctcatat 2258881 ccgcgaactt ggaaaggatc attacttgtt aaatgcaaaa ttattaatca gcgatgttaa 2258941 cagcctgctt ggaaccgatt tatcagaggc tgaagtagac accttgggcg gctggttttt 2259001 gacacaaaac atagacgctg agcctgaaag tgccatagaa tatgatggct actcttttaa 2259061 ggtaaaagac atcaacagcc atcacatttt atttatagaa gttaaaaaag ctgaatagcc 2259121 cgtgaaaggc tgttcagctg ctatctttca agataaacat ggcaaaggca tcaacactct 2259181 tttattttaa accctttatt ggccagggct ttagcaagac tttgctctgt tttcacattc 2259241 gaaaaatcca gacccagctt cacgacagtt tgggcaattt ccggcctgat tcctgaaata 2259301 atagtctcaa tgccgagcaa tttggtgctg tcaatcactt taaaaatttg ataggctacc 2259361 atggtatcaa cgataggaac gcccgaaata tctaaaaata aatacgagag ctttaacgct 2259421 gagcactgct ccagcacaga ctccaaaatc gtcctcgctc tgtgcgtatc aatttcaccg 2259481 acaagcggaa gaatcccaat tccatcagta atcggcataa tcggcgcact caattcatta 2259541 atcatttctt tttgcgcgtt taattgtatc atggtcacct ggtgatattc ttccgtaaac 2259601 acttcgatga tctcatcaat gttttgattc aagatccggc tccactcata aaattcctga 2259661 atgctgatgt cttgagaaga agcttcgctg aatttatgaa tccattcaaa catgatgtgc 2259721 ctgaaagtgt taaactggcc gacactttgt gtaaccgtca cttcatgaac ggcacggtct 2259781 ctggcgcatt gaagagacca ccggttgagc tcatcctcta cgtcttcttt tctaagggat 2259841 tttgctacga tggtcaccaa taattcatgc tggtctttta acttttgttc tagtttttgc 2259901 tgatctttcg ctgaatacag ccagctgccg tttgacgtac aaacttccag ccattgttgc 2259961 gtaatatctt ttttgtgctc tgttaagtgc tgatcaagag ctatcatctt aatgagttac 2260021 ctcctgtttt tgaaaaatgt acgctatata tgtataacgc gtctgccttt acacatacta 2260081 tgtttagatt caatgggcta tagccaagcg gtaaggcaat ggactttgac tccgtgatcg 2260141 ttggttcgaa tccagctagc ccagtttctg aacaggtgaa aaaccgaaga taagctgatt 2260201 cgtataaatc agcggatctt cggtttttca tcatgcagat tgatgaaccg ttttcttctt 2260261 cgataacttc aacagttctc ccgggttata accaatcacc agctttttgt tgtctactag 2260321 aatcgggcgt cgcaaaagct tcggcttctc gattaaaagt tccagcacct catttaccgt 2260381 catttcttca atgtttaaat ttaaattttt gaaagtctgg cttcttgtcg ccaaaatttc 2260441 atcaattcct tctgtcgtta acgataaaat gtactttaat tcttctcttg tcggggtttc 2260501 tctgaataag tgccgttcgt taaattcaat ttgatgtgct ttaagccaat gttttgtttt 2260561 tcggcatgac gtgcagcttg gatatgagta aaaagttaat tgttgttcca ttcgtttttt 2260621 cctcctcagt taaccatctc tttgtagaat aactacccgg atcatttttc atttaaacca 2260681 tttacagaac ttttttcgga ttatttttta aaaaacattc atacaataga aaacacaatc 2260741 aaagggacaa attccatttg tatattaata atgaaaatgt ttacatttct aggtgtgatc 2260801 tattataata acagtcagag ggactctcgg gaggggataa aaatgaatcg catgttccgg 2260861 gtgttaggat tttggacggg aatttttgca gtcatgtttt atttaggtga tatgaaagat 2260921 gcttcccttt tattttttgg acagacgatc ttatttgtgt ttctatcgta tttgaactta 2260981 accgaacgca tgtatattta tatttttggc gcttatttaa caattttctt cgccggcttt 2261041 acatattact caatttttat tatggtgccc ggcggcggag gccattaaat gcagaaagag 2261101 acaaacctta tcggtttgtc tcttttttta caatgaaaac ccatttaaaa acggattttg 2261161 atcctgctca gtcagtacgt ctgtttcagg tccatggccg cttaacacca gcgtgtgttc 2261221 cggaagcgta agcagttttt catgaatgga cgtcagcagc gtctcttgat tgccgcctat 2261281 taaatccgta cgtcctatac cgccttggaa caagacatct ccggaaatga ccaagtctgc 2261341 atctttcacg tagtaagaca cactgcctgg tgaatgtccc ggcgtaaata atgtttccaa 2261401 atgaaacggc ccgatattca actcaccgtc gccttcaatt agatgatctg caggcttagc 2261461 tgtgacttct atccctcgca gcatgccgga gccgtttaaa gaagcgtccg caagccaatt 2261521 tttttcattt tgatgcaggt aaacagggat atcccatttt tctctcactt catcaagcgc 2261581 cccaatatgg tcaaaatggg catgtgtaag caaaatggct aaaggcgtca gccctttttc 2261641 ttttatgtat tgattgattt tatgtccctc gccgcccgga tcaaaaatca gacattgatc 2261701 atcactgatg agaaaatatg cgttcgcttg aatcggccct actggcattc gtctccattt 2261761 cactattatc acctctttct tttttatgct cttattatga gggtttttga aaaaagattc 2261821 aaacaatcgc aatgaaaacg ctatcgacaa acctataaaa aacaggtaga ataaaactgg 2261881 aaagaattgc aggtttttca atgtaaaggg ggctgtgtta tgttacttgt cgtgattttc 2261941 ggccttgtcg ctcttttcgc tttatgggga gtcttgcgtt ctgttagaaa taaaaatata 2262001 ctcgggtttt tattagccgg tgccacctta tttgtctttg gatggtttac cgtgatgacc 2262061 gtaataaaca gcgggtatcc aaccgcacat taaaacctgt atccgatcgg atacaggttt 2262121 atttttatgg ctgtaaatgt ttattgacac tttctatttt gctctcaagc gtcgtttttt 2262181 tgtcacgcct gtcatcgata cggatattcg ttgccactct gtgcaatcct ttttgaaatg 2262241 gcgcttcgtg aattgcctga ataactgcaa aaaggtcact gagttctccc tcgatcagcg 2262301 tattcatcgg tgtcagctga tatttgattt tcccttctgc ttgatatcct tctaatatct 2262361 tttgcacatc ggctacgtaa gcactgacac tgggtgtttc cgtaccgatt gggataatgg 2262421 ttacatctgc gatagccatc gttattccat ctccttttga tcaatgatga gttgcttcgt 2262481 ttcatgtgat ttcaataaaa taatttgctc aaaatgaaag ccgtataacg catatttccc 2262541 gttcggagat atttgaatcg gctccatttc ccgcagagac acaagatctt ttgtctctcc 2262601 cgatgctaca ttgattgctg cgagcttata tgcatcgccg ctttgtttga atgtataaaa 2262661 caggcctcct gcttcatcat agtcatactc cattggagcc aaacttgtat atttcgcttg 2262721 gagcggccat ttcgctgtaa caggtgatgt tgattgcggc gttttaaact gatacgtccc 2262781 ttttcctccg gaagctgatt tgacagtaaa actcatttga tggaaagaat cgaagaatag 2262841 aacgttatcc tcaagcttct gttccgtctt agaagctgta tcgaacgtat ataaaggccc 2262901 tgttttatcg tctctaccct cttttacata atcaaatgta tttttggatg tccaatgaat 2262961 gaacggaacc tgtactgggc ttaagaaaga ttcgtctttt ttagcattca cctgatatgt 2263021 atggaaatcc cagttttcat tgaattccgt caccatcatt tgataaggat catactgatt 2263081 ccaagcagct tcaagctcat acgtttcgta atctttttcg taaagcgtct ctccttctgc 2263141 attaagcaaa accactgccg tcttttggct atgtgtgatt tgcagcagaa tcatctgctc 2263201 cctcgcattg atttgaacat caacgatttg accatccgtt tgatagagct ttttcgcttt 2263261 gcctgtaaag atgcggtacg caaaaagctc tgttttcgtc ggattagacg cagtatataa 2263321 tattgtgctg ttattcagcc agccttccgc cccatccgct ttttccgcgg aaagcggtat 2263381 gatgtctttt ttctcatctt ttgccgccga tgcctgtttt tgctgctgat gagatggttc 2263441 gcatgccgat aaactaaaca gcaataccgc cagcagaata aaacaaactg atctcatcag 2263501 cattcccctc cgatcatctt tattctctca tatttgcttc ggcagaaaaa agaaaaagtt 2263561 tcagttactc atgaaaaaat aacgccctcc acaagatacc gcttgtggcg ttatatatgt 2263621 gtgaaaactg ctgaaacggc aaaggatttt ggccttttcc aagttccacc gtataccctt 2263681 ccttaaaata atggtgaata aaccaatcac gaaatccagc atagctgtct atatccctta 2263741 ctcccttata aatgttcccg cttaactcct caaactcctt tatgacggca gcagattcct 2263801 caggctcaag gcctttatag ccccaataaa tttcttctcc ttgagtatga agagccagca 2263861 gtctgtcagg cggattctcc gtgatcagcc ggtacatcgc aatagattcc ggctccgtaa 2263921 gcggagagat tcccggaaaa tcgcggtagc tgggtgctgt cggttttcgg tatttttcaa 2263981 tttcccataa tgatggaaat tgtttattta aatcaacccc gtttatattc gccttccatt 2264041 cattaaaatt tggacgatgt tcatttagcc tttcgagttc atctcttctg gctcccatga 2264101 cttctgatcc gtttaaaaca agatcaacgc catccggatt gacaagagga acgagggata 2264161 aggatgtgct gttaaacagc tttatgggag aaaagccaaa gaaaggcgaa ttgcagcata 2264221 atgacataca gtattcctta aaccatttta gcaggacaga cgttgtaatc cactcattcg 2264281 catgaaatga cgcgttcata tggacctttt ttacggcatg ctccccacca gccttcagct 2264341 cccagatagg cctgccgagt acagaacggc caatttcccg gcatgagaca aacggaaaaa 2264401 catcaataat cttctttatt tccttttcaa cagctgaatc atcatagatt ttctcttgct 2264461 caatccagct atctgaaagt ttcagctgcc gaggctgtaa aaagcgcttt atgtcctgaa 2264521 tggtttgaag ctctttgccg ctatgctcct ctatcacata accagggcaa tacaattgat 2264581 gtttttgtgc ggagcgattt gcacttttaa gcaattcctc gtctatcttc agttctttcg 2264641 ccacattggc caaattgttc ttgatctcag gtttcaccgt aataaacgcc atcatcatcc 2264701 cccttttttg ttactatatg acagcgtatt taaaaaaaga aagcctcccg ctcacttcga 2264761 tgcgggagac attgtgatta tgatgcctga tcaagcattt gtttttcttt ccgctttgac 2264821 gaattgtcca gccttttctg gtcataaaat cgcaacaaat ccccataaat gatttcatca 2264881 gaaagtgata gctcctgttt tgctttatca gcaaatgctt cacattgttt tgtctcttct 2264941 aacggttttc ccgtctcttt gtcataacac gcaccgtctg tataaacaac ctgatctgtg 2265001 ataaagctcc cgtcccggag caccgtgaag tccagttttt cgtctgaaag cagatcgttg 2265061 ccgaattgaa tttgatcttt cgtatcaatc cctaaaagat tcatcagcgt cggcctgata 2265121 tcaatctgcc cgcctactgt ttcaatggtt tgcggctttt tatcagtaat acccggaata 2265181 tgaatgacca gcggcacttt ttggagctgt acctcttcaa atggggttat ttcttttcct 2265241 aaaaactgcc ccatcgcttc attatggttt tctgatatac cataatggtc accatataat 2265301 acaataacag agttgtcgta taacccgtct tccttcagct tttcgataaa ccgtttcagc 2265361 gcctcatcct gataacgcac tgtcggaaaa tatttattta gcgtctggct gtttgaatca 2265421 tattcatcaa tcaattgatc ctcttcatca agatcaaacg ggaagtggtt cgtcagtgta 2265481 atcagcctcg agtaaaacgg ctgaggcaga tttttcatca gctctgagga ctgctcaaaa 2265541 aattctttat ccttaagtcc ccagccgact gaattttcgt cagttacatc atacgagtta 2265601 atatcaaaaa acgaatcata tccaaatgag tcgtacatta aatcacgatt ccaaaagctc 2265661 ttattattag cgtggagcac cgctgaatag tatccgctgt ttttcaaaat ttcaggagcg 2265721 gccatatatt gattgcccgc attcgtaaaa aatacggcac ctcgtccaag cggatacagt 2265781 gaattgtcca cgataaattc agaatccgag gttttcccct ggcctgtttg gtggtaaaca 2265841 ttattaaagt tgtagctctg ttttataaag tcattcagaa aaggcgtgat ttcttctcca 2265901 ttcaattttt cattaatcac gaagctttgc gtcgactcta aggatacgag aatgacgttc 2265961 cttccttttg cagcgccgaa taagcgtttg ttggcatcct tcgcattagc ggttacgtag 2266021 ttttcaatct ccgtcaggct gttgctgtct gccaacgctc tctgtgcgga ttgctttgac 2266081 tgaagaacgc catcgtaaat atgaaaatta aacaggctaa tgtttttaac aagcatttct 2266141 ctgtcaaatg agcgtgtcaa tagctgaggt ctttccgcct cagacaagcc caggttgaag 2266201 aaataaacag aagcaacgaa caaaaaataa gccgcccgtt catttttcgt tgagggaatg 2266261 tccgattgaa aagctttttg ccggatgtga agccatatta aaaccgcaat atctacagct 2266321 aataggaggt ctgtcggctc aagaagtgtt ccgatgctgc ttccgagatc acccatattg 2266381 ctcgtttgaa aaagaacagg gattgttaag aaatcattgt aaaaacggta aaaaaccata 2266441 tttgccagca atacaaacgt gacaagacag ctcatcgcga taatgtagcg atttctgttt 2266501 ttgcctttta aaaacaggct gaggccaaaa ataagcaaca aaaaactcaa tgggttgata 2266561 aacagaataa attcctgtgt tagattgtcg attttaatat gaaaactggt tttgtaaaca 2266621 gcatacgttt tcagccacat caataaaatg gcaatcagca taaatgaaat cttcgaaaaa 2266681 aacgtttttc gcatttcaac ctcctatgca gcacgctcaa aaaaatcagt ctattcccaa 2266741 cattctcatt aacacatcaa attaaatctt aacctgagca caacaaaaaa tcaatttcat 2266801 ttacacaatt ttaacaattt tgatgtttca gccattcatt tttagcgatc caagcgcctc 2266861 cgataacgcc ggcatcattt ccaagtgctg cgattgaaat atcagcagct tgggctgccc 2266921 gcggaaacgc gcatttgcgg aatgttttct cgacttttga tctcagcagt tctccggctc 2266981 tcgatacgcc gccgccaaga acgattttgg atggattaag cgagcttgcc aaatttccga 2267041 gcaccaaacc aagatgcttg gctacataat caaccacctc aagggcaatt tcatcatttt 2267101 cacccgccgc ttcaaacaca tctcgcgctg acaattgttc ggttgctttt aaacgtgtcg 2267161 tctttttagc atttgctatt ttttcttttg caattcttac aattccggtt gctgacgcaa 2267221 ttgtttcgat acagcccgtt ttgccgcagt tgcagggcgc tccgccttca gggatgctgc 2267281 aaatatggcc gatttctccg ccggcgccat ttataccatg tacaatttca ccatttgcaa 2267341 tgatgccgcc gccaactcct gtgccaagcg tcacgagaat gacgtctttt gcgccatcac 2267401 ccgctccctt ccacatttcc ccgagcgcag caatattcgc gtcattttct ataacagctg 2267461 ggatgccggt ttctgtctcc agatggtttt tcaaagcata atttttccac cctagattta 2267521 ctgtttcata aaccactcct gccgccatat ctacagggcc tggtgcaccc attccgatgt 2267581 atttgatgat gtgcttcggt ttttgcagct catccagctt gctgtcgatt gtttttgcaa 2267641 ttgtgacagt aatcgtgtcg ccggttttat ctgtcggaac ttcccactta tgctgaattt 2267701 cgccatattg attaataaaa gcgagtttaa tcgtcgttcc tcccaggtca atgcccgcaa 2267761 accatatctc gtccattttt atcaccttag cctttataaa aatctcttcc gttttttgtt 2267821 tgttccaatt cttttcgaag gacagctgcc gctctggccc actgctcctt ttcaatcatg 2267881 tggttcatgt ataattcctt taattcatcc agcataaact caatttcaag ctctctgtct 2267941 ccaaaataaa caatgtggcc aaacgttttt aacagctgct gcacatcata aaatgtattc 2268001 attttcctca ccatttcttg aacttaacta tcataagcgt attcataagg aagcggtcag 2268061 tcaagaagaa aacgctgaca aaaaagccag cttcctttcc atattccacc tctatgattc 2268121 tttattgttt tcaatttgcc gctgcagctc cttgtagcgc tgctccttcg gcttcagttt 2268181 cacagccgtc tggatggcct tttctgcttg tgcaagctca tttttttccg catacaataa 2268241 cgctaaattg taataggaag catggtcttt aggttctttt ttcactgctc gttccaaaag 2268301 ggaaaccgcc tgatcatatt cgccgatttg aatatcagaa acagcaagaa ttttcaaaag 2268361 atcggcagag gcatcttttt gcgctgcttc tccgttcagc aattctgtta cttcttcata 2268421 ctttccttcc tgatacagct cgcttgcctg ctgaatcagc gctgactcct ggtgtgaagg 2268481 cgaatgcaat ccgtaatata aaaatccaac agccaaagca atcagcaaaa ccgctgacaa 2268541 caatcttttt ccaaaggctc cggctttagg caaccccagt gctgctgcag cgaaaaagcc 2268601 gccaatcaag ccgccgatat gtcctgaatt atcaatattc gaaaccgcaa aaccaaagcc 2268661 cagattgatg ataataatga caataatatt ggttcctata gttcttaaaa acatttttcg 2268721 attagacaaa gcaacataca gtaatgcacc taagcatccg aatatggctc ctgatgcccc 2268781 tgccgaagga tacgggctga acacaaaact cgcaatcgaa cccgtaatgc cagcagccag 2268841 ataaatcagc aaaaatctcc ccgatccata catccgctca accgctgtac caaccgacca 2268901 taaagccagc gtattaaaag ctaaatgcgc tatgccgatg tgaagcacga tcggtgtcag 2268961 aagccgccac cattctcctt gtgcaatcag gctgttttct tttgctccaa aagccaccag 2269021 tgtctccgta ttagtgctgc ctccgtttat ttcgagcaag aaaaacatca ggatctgaag 2269081 cgcaataaat aaatatgtaa aagtcggttt tccgttttga aaaaccgccg cttcagtttt 2269141 tctctgttct tcttgtttca gcactagcga aaggaagcgt tctcgcgcca tttgcgcgtt 2269201 ttcaaacgaa gcgtgttcct ctgaacaatc ttctgtacga aatgatggaa aaaccgcttg 2269261 aagatcatct cgaagcatcg ttcctctaac gatcgccggc tcaactgaca cagttccctt 2269321 ctcaaaagtt ttttttgcaa tctcttccca gtcatcaact ggggcttccg ttgaaaaaaa 2269381 cacgttcagc agcttcatcc ttcgtctgcc caattgatgt ctgactcgtt ctactcgttc 2269441 ggcctgctct tcgatgtctc taaccatttc ttgacggaaa tcaagatcgt gcttataaag 2269501 acgaactaga tcatgagagg acttgtccgg cgcttccagc catatttcat ctgactcacc 2269561 ggcttgtatg acgccatacc cgctattcac caggtgcgcc gcaattttcc aatatgtata 2269621 ctccagcaaa aacatgttta ccgctccaat agtttttttt cattataaca gctggcgctc 2269681 cgaaacgcct actgaaagca aaaaatcccg tttttcacgg gattttagaa agcttgctgt 2269741 ataaacttat tgcggataaa tggaattctt aaaaacaaat ggataaaaga ccgcctgatt 2269801 cctggctggc tgagtacagt attcataaga cggtagcgat tttgataaaa catgacggca 2269861 gaaaccgcga aaatggcata tatcaaaagt tttttcatga tatccctcct gccaataggg 2269921 tttgttattc taccttattt attctcgaat aagggacagg aaagttatga aaaacaagaa 2269981 ataatccgat cctctgttat cagcttatgt accgggatgt catgcggcag acggggtacg 2270041 tgcgcaaaca actggcactc caaaagcaaa gagactgtct tcccttcata ttcacttaaa 2270101 tagcgatcat aatagccgcc tccaaagccg accctaaacc cgttaacatc aaaacaaaca 2270161 cccggaacga tcatcaagtc aatttgtgat gggtttactt cttttgtttt ttcaattacc 2270221 ggctcgagca gtccggcgta cacggtttcg agctgatcat cagtctgata tgtgcgaaat 2270281 tgcattttct tcgtgtccgg atggcatttt gggatgcaaa cttgtttccc ttcttcccaa 2270341 gcctgctcaa tgacaggacg cgtcggtatc tctaatcctc tggaaatagt gacggcaatg 2270401 gtgccggcat tttgccactc cggcagagaa aacaagtact tatacatacg ttccgttttt 2270461 tgaagaatat cttcatttga taaagcagac agtgcctcca gcgtcttttt tcttaattgt 2270521 gatttcatct ctcatccccc tcggaataga aaaaaagcca gaaccttttt caaagctctg 2270581 gcttttttct tacacctcaa acagcaaagc tgttattttg tttcacggtg taacgtagat 2270641 tttttatcac gtgggcaata ttttttaaat tcaacgcggt ctggattgtt gcgtttgttc 2270701 tttttagaaa tatagttacg ctcaccacat tcagtgcaag ccaaagtaat attaacgcgc 2270761 attattttcc ctccaaacta aaatcattta cttattcaga cttatatata ataccactat 2270821 aatggacgga atgctaggct gtttttcaat gaattgctga attattgaag atacgctcat 2270881 aaagctgcaa atatgatgac ataatgagtc gggggtggtg gagcttgaac acttgttgtc 2270941 tgccagcttc ttttatccgg cgggcttttt cccggtcttt taaaaaactg tccagcagat 2271001 cagcagcttc ctgtacgagc gtaaaatcag cgatgattgc cgttttgtca tgaaccgcat 2271061 aatcacaaaa accacctgac tgagaaacga cagtcagcac accttgttcc atgctttctt 2271121 gcgcggcaag cccaaacggt tcataagaac tagggaaaac agccatttca cagtgagaca 2271181 gtaacgttct gatatctttc ctatttagaa acggcagaaa catgacgcga tccttcaggt 2271241 tatatgccgc agccaatttc tcatagcagg acagagacgg cccctcccca gccagcacta 2271301 gatagaggtc aggctgacgc tgcttcaaga tggcaaacac ctttaacagc tgcgataatc 2271361 ctttttccgg aacaaacctt ccatatgaaa agaggaatct tctattcatg cttctcggga 2271421 ttttcccctt ctcttcctcc atagatgcag ggcttgggat aacggttatt ttcttatgtg 2271481 ccgccttatc aagagaccgc ttcataaatg tgcttaatac gatcaatgca tcagcggatt 2271541 ctataaggag ccgttcggtc atgagcctgt atgggtgtgg ggcttctcgg cacaccttct 2271601 tcctttcgct ttcaagaccg tggattgtcg cagcaagcgg aaggccaagc cgttgtttca 2271661 aatactgggc ggcaggggca gttgtgtcat catgggcatg aatcagatca aagcgtttat 2271721 tgtgtgataa cacatggcga accattgtaa agttagcatc agctatgtaa tcttcaaact 2271781 tcgcatacga aaacagctgc ccgctcggag taaaaaccgt aatgttgata tgagggttta 2271841 aataggaaat gaggcggttt aaatggacac cgagcccgct tttcggctca tcgggatgtt 2271901 cgggtgaaag catgagaatg ttcaccgttc tttttcccct ctcccataac aggtgtatgc 2271961 agaaaattgc gcctcccacc tggtgtgcgc ttcttcaatc tgaaaactgt ttatatgacg 2272021 aatcccattt tcatcaagat agatgtcgtc tgtaccggca agcttgagag agacattcat 2272081 tgaattcaca attctgtatt cagcccgata tacagcatca ccagccgcct gtctaatcgt 2272141 ccattctcct ttatcatacg ttgtgcgttt tgtcctgaca gcttcaatgt cttttctttt 2272201 gatgacaatg cgcaattctt ttatcatatc ctgcgttttt tcgaaaagga ccgcttcagc 2272261 cagccgcatt gtttcttctg agatttccca gcttacggtc aaggtgtgag cgttttgaat 2272321 gattatgtcg aatgtgtccc taaaaaagga aagcttatgt cgtatattat agggaaatgg 2272381 gtgtttatcc atggactcct aacattctcc tttccaatcg ttcacttcgt gttcctatta 2272441 aaccattaca tgaagaagaa gcgaagaaag atttctcgac aaaatctcgt ttttttcgcg 2272501 aattccttta gaaactattg gttttatggt ataaaaaaga aggataaaaa aagaatagaa 2272561 ggtgatgaaa cgtggaaatt gctattattg cgttgtttat cgtcagtata gcgctaattg 2272621 cattctcata ttctcaaaga gacccgatga aagatgtaga acaggagctc gaaacactgc 2272681 agctttctgc gatgcaggaa atttacaagc tcaaaaagaa aatgacagtg cttgaggaag 2272741 aattactgga aacaaacctt gtcattcgca aatcaaagca gaacgacatc aatcaaaaaa 2272801 tcgctaaaca aatactttct aaatataata acggtatgtc agctgaagcg attgctaaag 2272861 ctgaacatgt atcagtggaa gacgtgaata cgattatcaa agataatgag aaggtgctcg 2272921 tatgacaaaa cggggcattc aggcatttgc tggcggcatc attttagcga cagccgttct 2272981 tgcagctgtt ttttatctga ctgacgaaga ccaggccgct gctgtaaaag ataataaaac 2273041 agtaaccgaa caagacgtga acaattatct tgattctaaa aaattggttt ctgtcaaccg 2273101 tgatgaatat caaaaacttc tcgattcaaa agagaaatcc ttaaacaatg acagcggctc 2273161 agacacgaaa tcagacaaag tcaaaaccta caagctcacc attaaagacg gcatgagcac 2273221 ggcggatgta tctgctattc ttgaaaaaga gggcattatc tcttcggctc aagactttaa 2273281 tgactatgtc attgatgccg gctatcacaa agaaattcgt gccggcgagt ttaaagtaaa 2273341 atcagacatg agtttcaaaa agatcgtaaa aacgttaaca cgataaaaaa acaggctgac 2273401 tcagcctgtt tttttcatcc aaactttcct gaaatgtaat cgagcgttct ttggtccttc 2273461 gggttagaga acattttatt cgtattgtcg cattcaacaa gctcgcccat gtagaaaaag 2273521 gcggtttgat cagaaaccct tgctgcctgc tgcatgttat gcgtgacaat gacaattgta 2273581 tatttatctt tcagctctag aatgagttct tcaatttttc tcgttgagat tggatctagt 2273641 gcagatgtcg gttcatccat cagcaaaata tcaggattgg tcgcaagtgc tctggcgatg 2273701 caaagacgct gctgctggcc ccctgacagc gaaagagcgg acgtatgcaa tcgatccttc 2273761 acctcatccc ataacgccac gtcttttaat gacttttcca caatttcctg aagcttcttc 2273821 ttatttttgg tgccgtggac tctcggtccg taagccacat tatcaaaaat agattgcgga 2273881 aacggattcc ctttttggaa taccatgccg atattttttc gcaaatccac gatgtccact 2273941 ttatccttta aaatgttgct gccattatag ttcagctcac ctgcaagctt tacattcggc 2274001 gtcatttgaa tcattaaatt caatgtcttg ataaaggtcg atttcccgca tccggatggt 2274061 ccgataatcg ccgtaacctc attttcataa atgctcaaat tgatattttt taaagcatga 2274121 tgctgcccat accataagtt cattccattg acttgatata cttcctgttt cattacagct 2274181 tcggtagcaa tactcattgc cgccctccta tccgaatttc ccgttaatat aatcctctgt 2274241 cttttgcttt ttcggactcg tgaaaatctg ttcggtctgt ccgtattcta caagctcgcc 2274301 gtttaaaaag aatgccgtcc ggtcagaaac ccgcagagcc tgctgcatat tgtgcgtgac 2274361 aataataatt gagtattctc ttttcaatcc tgtaattaat tcctctattt ttgcatttga 2274421 aatcggatca agcgctgaag ctggttcatc aagcagaaga acagccggct tcatcgcaag 2274481 cgttctcgcg atgcataaac gctgctgctg gccgccggat aacgagagtg cggatgaatg 2274541 taaacgatcc ttcacctcat cccagagcgc tgcttttgtt aaactttctt ccacaatttc 2274601 atctaaaaca gctttattcc gctctccggc atatttcaat gcatgtgtga tattcgcata 2274661 gatcgatttc ggaaatggat ttggtttttg gaaaaccatt ccgatttctc ttctcaagct 2274721 gacaacgtta atattgccgc ccaatatatt taatccctca taaaggattt caccttccgc 2274781 tcttgcagat ggaattaaat cgttcattcg gttaatattt ctcaaaaaag tagattttcc 2274841 gcatcccgac ggcccaatta aagcagtcac cgcatttttt tcaatatcca tgtttacatg 2274901 atgaacggct tgtttatttc cgtaataaat ggacagatct ttgacctcaa gcacgtggtt 2274961 ctgcttcgga acaataacag ctcgctcagg tttttctttt accatttgtt cagacatgtt 2275021 tttcgcctct ttccgttcta atttgccgta agctttttgt agatcatcgt gccaagccat 2275081 ctcgccgcga gattaaacac aagaacagaa atcaccagca cggcagaacc accgttggca 2275141 atcgcttcag catccggaat cattccttgt gtattgacgt tccaaatgtg gaccgcaagt 2275201 gtttcagcgg gcctgaaaat attaagcggt gatgtttccg aaaacgggtt ccactccgta 2275261 aaattaagac gcggtgttgt caggcctgcc gtaaataata atgcggccgc ttccccgaac 2275321 acccttcctg acgctaaaat tgctcctgtg atgatagaag gaatcgcact tggaattaaa 2275381 actgttttta cggtatgcca gcgtgataca cctaaagcga gagaggcttc cttcagatct 2275441 ttagggactg aacggatcgc gtcttctgtc acacgcacca tgacaggaag gttaaaaaca 2275501 gttaacgcaa gcgctccgcc tatgatcgta taaccccagc ctgttaagtt gacaaacatc 2275561 aataatccaa acatcccaat gacaatagac ggaagagatg aaagcacctc tatacatgtt 2275621 ctaatgaagt cagttacttt gttattaggc gcgtattcag ccatgaagac tccgccgccc 2275681 acaccgagcg ggattgtaat cagcattgta ataaacaaaa tataaaagga gttaaacagc 2275741 tgatctcgta tgcctcctcc agctgcaatg gcgctcgact ttgttgtaat aaattgaaaa 2275801 ctgagctgag aaacaccgtt tataataata taggaaaaca aacctactaa aatggcagcg 2275861 ataatggctg cacacaaacc aaacattccg gtcgccagtt tatctgttat tttgcggttc 2275921 attacacttt cctcctagat gacaagtagc gaataagcag gatgaacaag aatgacatca 2275981 ccagaagcac aagccccatt gaccacagcg tattgttttc aacacttccg tatgtggtgt 2276041 ggcccatatt cagcgtgatg atcgttgtca gcgttcccgc agtgtcaaac gggctttccg 2276101 gcaatactct tgtatttcca atgaccatct gaacagccaa agcttcaccg aacgcccgag 2276161 ccatgcctaa cacaacagct gtcatcaatg ttggaaaagc tgcaggcaca agtacttttc 2276221 tgatcgtctg ccatcttgtg gcaccaagcg cgtaagaacc ctctcgtaaa ctcttcggaa 2276281 gagaagccat tgcatcagca gaaatcgatg tgatcgtcgg cagaatcatg acggaaagga 2276341 caatcgttcc cgccaataaa ctgtgccctg ttccgctcga tttgaactgg gcgataaacg 2276401 gcaccaatac tgtaagacct atgaatccat aaacaacaga tggaataccg actaaaagct 2276461 caatcaccgg ctgcagcact ttctttcccc aattcggggc aatctctgtc ataaaaatcg 2276521 cacctgcaat gccaagcggc gcagcgatta gagcagaaag aatcgttact gcaaatgagc 2276581 caaaaataaa tggcagcact ccgtatttcg gatcactatc tgtaggattc caatttaagc 2276641 tcgttaagaa ttcaattggg cttacaccat ttacaagaaa agattgcagc cccttaacgc 2276701 cgaggaaaat ggtaatcgca acagatgccg caatcataat cagtgcacaa gctgtgacta 2276761 tcattcttcc ccgaacttca tccaattgcc gattttgcct agagctgatt aagcgctcgc 2276821 tcacagacat attttctcta ttgtttatca ttgttttaca ctcctatgaa tgtgttaaga 2276881 ggagaaacgg ttgtccccgc actcctcttt ttattaagat cagctttgct tcccgttggc 2276941 atcacgtgtc actttcatat cagtaaccgg aatgtagcct tggtcagtaa caatgctttt 2277001 ttgaatgtct tcactcttta gataatcaag aaattcttta gctaaacctg tcgcttcacc 2277061 ttttgtataa gaatgttgat aagcccagat cggatactcg ccagttgcta catttttcgc 2277121 ttcaggttta acaccgtcaa tagatagagc agttactttg tcatctgtta aatatgagaa 2277181 tgcaagatat ccaatcgctc ccggagtatc agcaatgatc tttttcaccg tgttggagga 2277241 atcttcagta atgccttctg caggctccgc tccgtcaagc gcatatttca caaatgtagc 2277301 acgtgtgccg gaagaatcag ggcggtttac aagtgtaatc ttttggtctt tgccgccgag 2277361 ctctttccag tttttgattt tgccagtgaa gatttttttc aattcatctt ttgaaatatc 2277421 ctttacacca gcatcagggt ttacagctgc tgccatacca actacagcga cttgatgatc 2277481 gacaagcgct tttgcatcga tgccttcttt ttcttcagca aaaacgtctg aattcccgat 2277541 ctgaacagct ccttcagaga cttgagaaag ccctgttcca gaaccgccag cttgtacctg 2277601 tatatcagca tcagggtttt cttccataaa tttttccgcg gctgcaagta ctagtggctg 2277661 cattgccgat gaaccagaaa tggttaaaga acctgatgcc ttttcttctc cttttgcaga 2277721 atcgctattc gattttttac tttctcctgc atttccgcat gcagctgcaa tcatcataaa 2277781 agcagccatc agaagcataa gcaccaattt gttttttttc atttcctgaa ttccccctgc 2277841 gtataatgtg taatttgtcc tacacgtata gagtaaaggt tctatgtaaa aagggtttga 2277901 accgaatgtt aaggttttgt aaatcagtgc gtttttttgt ataaaaaaaa cgcccacatc 2277961 atgtgagcgt ttttttttag ttatcagaag acgttgtgtt ttctgcattt tcttcaattt 2278021 tgtctttatt cttttgctga gtaccttctt tgtcctgctt cgatttcagc tcaaaatatt 2278081 tatccattac ttccctgccg atttcgtttg taattgagta tctttgattg taatcaatgt 2278141 aagtccaagg aactacgaca gaaatagcaa tctcaggatt gtcagctggt gcataagcca 2278201 caagcgtcgt attataagtg tctgttcctg tttttgattt atccggtccg tcgtaaaatg 2278261 attgggctgt tcctgttttt gcagctggtt tatacgatgc tgaagccagt tgacctgcag 2278321 ctgtcccttt agtggcaacc cgtctaaaac cggcttggac ctcttcaata tagctactct 2278381 tcatatcgac tttattcaat acttcaggct gaacagaatc aacgactgcg ccgatccctt 2278441 ttttcgcatt tgaatctctg acttccttta caagctgagg cttcatgcgg tagccaccat 2278501 ttgctatggt ggagacatat tgagccaatt ccagcggtgt ataagtatca tactgtccaa 2278561 tggcgaaatc aagcaagaaa ccagataatc tgcttgtacc tttatatccc gtcatttcat 2278621 ttggtagatc aattcctgtt tttactccta atccaaattg actgaaataa tttctgaagg 2278681 tatcaaatgc agaagtatcc aaaggcaatg cttggtgagg tttatattca cctttaccaa 2278741 ctgcaattgc tgttttaaac ataaaaacgt ttgatgactt ctctaatgca gtttgaatac 2278801 caaccggccc taagttttgc caagattttt tccctctttt atcctggccg atatacaatg 2278861 gttcatcctt aaatacagta ttcaaattaa tcgctccagt ttgaagaccg gtcaaaacgg 2278921 ttgcaccttt tacagctgat cccatagcgt aggatgaagt catggctcct aatgcataat 2278981 catcaaactt ataggctcca ttttctcgtt taatctgctt ccctgccatt gtcagcactt 2279041 cgccgtttct agggtccatc atgacaacga atgcacgatc caacaattcg gtactaggtc 2279101 ttgctttagc agctttaagt tttttctcaa taattttttc cactgatttt tgcaaatcaa 2279161 tatcaattgt tagtacaaga tctttcccgg ctttgccttc agataccgtt tttgttcccg 2279221 tgacattgcc ttttgaatct gtgatatttt cgacttttgc tttttggccc tgcagaaggc 2279281 tttcatattg gtattccaga tagctttttc cgaccctgtc atttcggctg tagccaagcg 2279341 acagataatg gtcgagcaag ttggacggca atccttcatt agagctggaa acacttccga 2279401 gcactgagcg aagaaggttt ttataaggat attcacgttc ccaatcggac gtgacatcaa 2279461 cacctggcag ttcgtctaaa tgttcactta ccactgccat ttccttcgct gatacatctt 2279521 cgtttttgat atattgaggg gtcaatgcat agcccgaatc catctgtctt ttgatagcaa 2279581 ggatctgcat atctttatcc gtcaattcat tcagctgctt atcagtaatc cgttttagct 2279641 gaagctggta taaatcgtca tcggatattt ttttgtcttc aacctgctgt ctttctttag 2279701 agctaatgag ctttttcgct tctttcggtc tagtcaaaat ccaataatct tttttatccc 2279761 gttctgttac tttttttgta tcgactttga tcatgtcaga cagctttttt gcgatcttta 2279821 agcgctgttc ttgcgtggtc gatttagatc tcgtgtatgt gattgcattt aaagccttat 2279881 ttgtcacaat ggcattaaag tttcgatcat aaattttccc gcgtggtacc gctgagctga 2279941 cttcactttg ttcctgctta ttcgcttggt ttttgtaatc atcaccttgc acgatctgct 2280001 tgatgcccag ttccacaata atccaggtaa atataacaaa ggcagctaaa aataaaatat 2280061 tcagccggat cggaagcgac ttctttttct ctttatgatt ttgctttttt ggtttatttc 2280121 tcctcataac atcacctttt ctatttacag aaagaaaaga cactcaagta agagtgccag 2280181 ttttcatttt aaaggttttt tcgacttttt tctacagata accccttttt ggcaaaaaaa 2280241 ttatctctcg ccttttaaaa gggtcggttc tgttacccgt ttttggccgt cttcttccat 2280301 ggtttcattt tccccttctt tctccttaaa acgaatatcc ttgacaaagt aataaatcaa 2280361 aggatgtcct atacccaata tcgcaagtga caaaggaatt cccacatcct ctttcagaag 2280421 ggccacaatc aggagaaagc acaaaatgga aacaattctg ccggcgttca agaacatttc 2280481 tctaagcacg atatattcaa ttcttgcttt tctggcatgc ctcgcgcgcc ctatcacatc 2280541 atatgtaagt gatacatatg gcacaagcaa cagaggatag ccgatggcaa taaaaacgcc 2280601 gtacgttaat aatgtcgaaa agctcatatg gaacagaatc aaaaacagcg cgccatacaa 2280661 aataagtccg cccagcaaaa tcgatttttt tctcgccttt ttcttaatca gcctggatgc 2280721 aaagtagtag gcaaagaagg aaacagctga attgacaaga ccgaatgtac cgagagcaag 2280781 ctcgctgttt gtctcaataa atacaaacac actgattaaa aagacaaaaa tcccttctct 2280841 caaaccctga aaaaaatgcg cattcgtgat tctccgccaa ttcatattgc tatggcgctc 2280901 tccaaatact ttgctcagca taaaacggcc ctttgattct ctccgtttta agaaaaagct 2280961 catcacgaca gccagggcaa ataaactgag ggagagactg aaaatcactg tataacccgt 2281021 attattttca agccttgaga tcacgaatcc ggctacaatc gggccgatca ttcctgcaga 2281081 ggaagacaga atgcccataa acccgttgaa aaagtctcgt gtatccggct ctgttatttc 2281141 aaaggtcagc acgttaaacg ctagccaata aaagccatag ccaactccga gcaccgcgcc 2281201 gattagcacg aggcggctgg ccgccgtttc tccggctaaa agcacactta aataaaaggc 2281261 agctaaaaaa atgacgccga accttaaaat gaataccctg tctatttttt tggctaaccg 2281321 tccagccaaa taaaaggtta tcggctgcat tgtcacaatg gataaattat atatcgccaa 2281381 atcaataaat ttccctgact gcttccaaag atacacatta acaaatgtat tggacagtgc 2281441 aattcccagc gagtaaagcc cgccaatggt cagcagaaag agtaagcctt tgtttacgtc 2281501 tacatcgcct atcacttttt ttagtttgct cattactgac tcccctttac tatcccttag 2281561 tctgtctcac tcaaaccgag atatgtaaaa agaagacata aaaaaacaag gtcccataat 2281621 gaggaccttg tttgtgccat tattttgctt cgctgtatag acgagccact tcgtcccagt 2281681 ttacaacatt ccagaaagct gaaatgtaat caggacggcg gttttgatag ttaaggtagt 2281741 aagcatgctc ccaaacgtca agacctaaga taggcgtttt gccttctgaa agcggagaat 2281801 cttggtttgg cgtgcttgtg atttcaagtt taccgttgtt cacaacaagc catgcccagc 2281861 cagaaccgaa gcgtccagct gctgctgctg cgaattgctc tttgaatttg tcaaagcttc 2281921 caaatacact gttaatctct tcagcaagcg cgccagtcgg ttcgcctccg ccgtttggag 2281981 ataaaagtgt ccagaataat ttgtggttcg cgtgtccgcc gccgttgttg cggactgcag 2282041 tgcggatgtt ttcaggaaca gaatcaagat ctgcaacaag ctcttcaact gatttgttgg 2282101 caagagcagt gtttccttca accgctttgt ttaaatttgt cacgtatgtg ttgtggtgtt 2282161 tcgtatggtg aatagtcata gtttccttgt cgatatgcgg ttctaaagca tcgtacgcat 2282221 aaggtaattc tggaagttcg taagccatga taattcctcc ttagtatata tgtactgaaa 2282281 tgccgcttca cagcgagcct ttcttcattc aatgtaacaa aagaatgctt tgtaatcaat 2282341 gaaaaagctc acgatttggc tcatttcagc ggacatattt cactttaacc gataatctgc 2282401 cccattaaac ctgccgccag catttcttat aggaccgtcc ataaaaagta accgatcatc 2282461 aaaagctgta tgatgccctt tgcaataacc cctgttaaaa aaccaatgag tgagccgagg 2282521 ccaattttaa acgctgactt taagtccttc tgatggacga taagttctgc gcaaacagcc 2282581 ccgataaacg gccccaatat gatccctgca accggaatga caaaaggccc gattaataaa 2282641 ccgatcgtgc ttccccatat ggcagctttg cttcctccga acctttttac tccaagcaga 2282701 ttcgacacgt aatctgctgc gaataatact gcggcaaaaa ctgcctcaac aagccagaac 2282761 atataagaat acggactgaa tgaaaataaa aatccgtaca atacaaatcc ggcaacaata 2282821 aatactacgc taggaataac aggatacacc agcccgataa aggcaatgat aaaaaccgct 2282881 gcaatcaaca gccaatacaa catatccata gcttccatcc tcccatttta ctctgtcttc 2282941 ttcatgtctt ccttgtattc acacgcatgc aacgatacaa taagcaacat atattagttt 2283001 agctaggaag tgaagatagt gaatgtgttt cagcttttca ttaaaagtac atactctccc 2283061 cgtgatattg caaaaacaag atttcaagga atcggaaaag cgattcttta tgtatttttg 2283121 ctctctgtcc tgtttgcaat ccctaccgct tattatgtaa gtacagggac cgtaaaatca 2283181 atgaacggct ttaaaactgt tttaaacaaa gatttccctg atttcacaat ttcaaacggc 2283241 aaacttcaaa cggatgagaa aaaagccacg gaatctcagg caaatggttt cgttatcgtg 2283301 ttcgatccga cagactccta tggcactgaa caaattgaag caaagcaaaa cgcaatcggc 2283361 atccttcaga acaaatttgt tttggccatt gacggacaag cccaagaaat gtcttactca 2283421 atgatgccgt cagagttaca gaaaaaagat gtcattgcag gtttaaacca aaataaagcg 2283481 atgattgtaa ctgttctctc agctcttatt tttctcgtaa cagcagcggg aaaatttatt 2283541 gaagtatcgt ttttagcgct tatcgggtta atcattaaga attcgcagaa aaaacattta 2283601 tcctatcatc agctctggaa gctttctgct tattccatca cactttcaac tgtattcttt 2283661 acaatcatgc gggcactaga agcaaccgta ccaagtgaat ttttgctgaa ctggtttgtc 2283721 aattttgtca tcctgtttct cgttttaaaa gagattccgt ccaaaaaagt aattaataaa 2283781 agttaaatta tatttatttt tatcctttaa gtagagagtg tgaaagcatt tgcattaact 2283841 ttttacttaa gggatattta ataaaatgta tagagcttaa acagatacat ttataaaaaa 2283901 agctctacaa ttactcaaga acaagctctg gacaataata tcagaagtag taagatgtaa 2283961 catgaaagaa gttcttaaca gcatttgaca tatgttttta acaaaataag aataatgtta 2284021 aattttaact aatagactag ttaaaatcat atggcaaaat attttgcatc ctttcacaac 2284081 atatttacat aagatagttg ctatttaaaa agccaggtac caatagggca cctagctttc 2284141 agaattaaat catcaacaag ttagaattat cttctttcct tctattctca ttattgaact 2284201 gttatctttt ttgtgggttt atgtatacaa atgcagctcc cttagctttc cccttatata 2284261 ctgataaacc tactgcccaa ggtgttcctg tcggttttgg taatttactg aagtaaaact 2284321 ttttggttgg agttctactt gaaaagtacc ctgaatattg cgggccaatg tccccaccct 2284381 caactataga tacaccaaag ctcttataat ttagtttacc gcattttcca tttgtttcgg 2284441 cgtaagcatc aatagatgtt gcactcttag tatatgtata agcatctgta ataactctta 2284501 ttttacaacc agaaatacca cttaccggtt gccaaccact gcttgcagcc tctgcttttt 2284561 ctttaggtgc aactaccaaa gttaacatta gtagcaaaat taaaaacaca gaaaattttc 2284621 cttgcttcat tttgtagatc ctcctttaaa ctattacata attatcctaa cagatccatt 2284681 gttcattgta aataatggaa tacgagtttt atattataaa agcctctttt tgatctaatt 2284741 ttgcactatt ttctattttc tatctgaagt taatgtttag tcgaagaaat cctgtcaaaa 2284801 aagcgcctgt ataaaaaccg agcattcgca gtctcttttc ttttgtcatg aatcgaaatg 2284861 gacaagcata ctatggtata aaatttcgta tgcgggagga aaagcgatga agcgtctcac 2284921 cttagtatgc agcattgttt ttatactttt tattcttttt tatgacctta aaattggaac 2284981 catacccatt caggacctcc ctgtctatga agcatcagca aaaacggctg tacaagaacc 2285041 ggcttataaa acggtgaagg taaagccggg tgatacggtt atgtcgatag tcggatcagc 2285101 aggttctccg gatgacattg taaaggattt tgaagcactg aatccaaatg tgaaagctaa 2285161 cgccattcaa gccggaacag cgtataaatt cccggtctac ccttaattta acgttaattt 2285221 cttgtcagtt cggcgaagac actgttacaa tgtaatttgt aaaataaatt cacataaacc 2285281 atactagaat tgttatatct agaagcggca actacaatta aggagcgatt gcaagtgagt 2285341 gaaatcacac atcgtacaaa aacgcgtccc gtcaaagtgg gacctttaac aataggcggc 2285401 aacaatgaag ttgtcatcca aagcatgaca acaacaaaaa cacatgatgt agaagcaacg 2285461 gttgcggaaa ttaaccgttt ggctgaagcc ggatgccaaa tcgttcgggt agcatgtccg 2285521 gatgaacggg cggcaaacgc cattgcggat attaaaaagc gcatttccat tcctctcgtt 2285581 gttgacatac atttcgatta taaacttgcg ttgaaagcca ttgaaggcgg cgcagataaa 2285641 atccgaatca accccggcaa tatcggccgg cgcgaaaaag ttgaagcggt tgttaaagcg 2285701 gccaaagaca aaggcattcc gatcagaatc ggagtaaacg ccggttcatt ggaaaaacgg 2285761 attttagaaa aatacggtta tccgactgcc gatggaatgg tagaaagcgc acttcatcac 2285821 attaaaattc ttgaggatct tgattttcac gatattattg tcagcatgaa ggcctctgac 2285881 gtgaaccttg caatcgaggc ttatgaaaaa gcagcgaaag cgtttgacta cccgcttcac 2285941 ctcgggatca ccgagtcagg aacactgttt gccggcacag taaagagcgc agcaggactc 2286001 ggcgccattt taagcaaagg catcgggaac accatgcgca tttcactaag cgcagaccct 2286061 gtagaagagg taaaagtagc aagggagctt ctgaaatctt tcggcttagc ctccaatgct 2286121 gccacgctca tctcatgccc gacttgcggc cgtattgaga ttgatctaat cagcattgcc 2286181 aatgaagtgg aagagtatat ttctaagata aaagcgccga ttaaagttgc tgttctcggc 2286241 tgcgctgtaa acggacctgg tgaagcgaga gaagctgata tcggaatcgc cggcgcacgc 2286301 ggtgaagggc tgctgttccg gaaagggaaa attgtccgta aggttccaga ggaaacgatg 2286361 gtagaagaac tcaaaaaaga aattgacatt cttgctgagg aacactacgc aaaacttgaa 2286421 gctgaaaaag caaaattaaa agaagaaaca caaaaagctt gacgggaacc cgtcaagctt 2286481 ttttgtgtta gaaaaatgga ataataaata ttccaagcac taatgaaacg acaccgatac 2286541 ccattgccca ggctccaagg ccttgagcac ctcttcttct tgcgatatag ccgacaataa 2286601 taccagcagc tcccaataaa acaggcagta caaacaatga aatgatggac aaggctaaag 2286661 cgatgtaccc tattccccgt ccttcattga cattgccgcc gctgcgatca ttgtcttggt 2286721 cattgctgcg gtcagcagca cgataaggct ctgcgatttc agcagctgtt tcctcaaaaa 2286781 aaccgtcatt gtcgcgggta atatttgtcc cttcagatcc atgatcaaca tagtaactgt 2286841 tgttatcacg cttttcgtaa tcgtttgcca ccttcaattc ccccttctgt tttattaaag 2286901 gagcttttat agtttgatcc attttgcctg attcatgttt gctaaacttt tctgttaatg 2286961 tcaattgttt atgttacact tgaagggatg aaactgaagg agtgtgggca tgttacgctt 2287021 aggaatagat attgacggca caatcacggc tcaggataca ttcgtccctt atttgaaccg 2287081 ttcgtttaat ctttccattt cattaaacga tatgacggat tatgatttaa caaagctgtt 2287141 aaacattacc caggaagaat tttgggattg gatgaatcaa aatgaagcga tcatatataa 2287201 ggaagcattg cttgcacagc atgcgaaaca gtctctcgat cttctcaaag aggagcacaa 2287261 gcttatttat attacagcga gacggactca tttaactgat attacttatg aatggtttga 2287321 cagacaaaac attcattatg accacatcga acttgttggg ggtcatcaca aagttgaagc 2287381 ggtcaagaat cataacatcg acctgttttt tgaggatcat cacgggaacg ccatgatgat 2287441 tgcgaaagaa gccgggatac cggtgatttt gttcaattcc ccttataatc agcttccgat 2287501 tgattcaaac atcatcagag taaacaactg gctagaagcc gttcaatgga tgaacaacaa 2287561 caagcatcac ttaatacgcg tcaataactg aaaaaggagc ccaaaccggg cccctttttc 2287621 atatatacgc attttacgca gtagtgtttt cttggttttc cgctgtacaa tcagggcatg 2287681 tgccataaat ctcaaattta tgcccgctga cctgatagcc atccaaatca tcacaaagct 2287741 tgtccatcgg acatgattca atttcctttg ttttgccgca ggcaagacaa ataaaatgat 2287801 ggtggtgatg ggtgaatgaa cacttaaatc ggaagagctt ttcaccggac agctcagttg 2287861 tttccaaaat cccaagttct tcatataaag aaagatttct gtagattgta tcaaagctta 2287921 agcctggata atcatcattc agtgcagaca gtacgttttt agcggtaaga tatctgtctg 2287981 aatcagcaaa aagctgcagc atatcctccc gtttgtttgt atatttatat ccgttttctt 2288041 ttaataggtt cagcgcttct tggacgttca tgaagggtcc cccttttcgc tttgcttaag 2288101 aacgtatcac atgtatgaaa aagaaaatgg cagctgtctg tccagcaagc cattttcttt 2288161 actgcagata aaattatacc cataaaatga ataaaagtaa atgaaagcct agtggattgc 2288221 gtttttgaat tttccgcctc tcgtttcatg agtattcata attgttatga atgcattttg 2288281 atcaacttca aacacgatcg atttgagctt tgtcacttcc agccttgtga caaccgcgta 2288341 aattacgtct ttttcttcgt ccgtataccc gcctttcccc ttcagcttcg ttgtgccccg 2288401 accgagacgg tgcaaaatcg cgtcggaaat ctcatcatac tgctcagaca caataatgac 2288461 agcttttgtt tcatcaagcc cttggatcac ggcatcaatc gttttcatcg caatataata 2288521 agtcatgaat gagtacatcg cttgctcagg accgaacaca aaaactgccc aaatgaaaat 2288581 gaacacattg atgaacataa cgaactcacc tacagaaaac gggagttttt tggtcagcaa 2288641 aataccgaga atttctgtac catccattga acctccattt cgaataacaa gcccgacgcc 2288701 aaagccgagt aaaagacctc cgaacacagt agccaaaata ggctgggttg taatggcttc 2288761 tacatggtga agtgaggatt caataacggc aagcccgaca atccctataa acgtagagac 2288821 tagaaaggtc ttaccgatat atttatatcc gaagatcata aaaggaatat ttaatatgac 2288881 aacgaaaaaa gcgaaattca gaaaggggtt tgacataaag aggtggtcta aaataagaga 2288941 tacaccgata atcccgccat caataaaatc attggggatt aaaaataatt caatacttac 2289001 agccgcagat gcagctccta ccagaatcat aaagaccctg aaaataaaat gggtaaatgt 2289061 ttctttctta tgttgttttg ttggggtcat aaaatctcct ttcctgcaat aactatttta 2289121 aatacattat aaatctattt taccattaaa cactgacaca ttttactgat ttgcccatac 2289181 attaagtctg gaggtggaat gaccgatgat tttatttcaa agaattattt tgcagcggct 2289241 taatcaggct actgctgatg atttgctgaa gtactcaaaa caatacggaa tcagcttaac 2289301 aagatcgcag gccgttgaag tagcgaacct gttatacggg aaaaatgtaa acatctttaa 2289361 tgagagtgaa cgaatgcggc tgctgaaaca agtagagacg attacatcga aagaaacagc 2289421 tcaaacagtt aatgaactat tcaaacaatt tacaagctaa aaaatggggg tgttatcccc 2289481 cattttttat tgctgtaaaa tcttttcaag caatgtatca tcaaattgtt tttctttcag 2289541 catttcaatc tcaaaacggt atggcggttt tttgttcttt ttatcttcac cgacgtatgg 2289601 tgtttcaaga atttttggaa tgtcttttaa ctgctcatgg tgaacaacat attgcagtgc 2289661 gtcaaaacct atttcaccaa agccaatatt ttcatggcgg tcttttctcg cacctttgac 2289721 atttttgctg tcattgatat gaagcacttt aatacggtca atgccaatga ttttatcgaa 2289781 ctcatttagc actccgtcaa agtcttcgac aatgttatac ccggcatcat gtgtatggca 2289841 cgtgtcaaag cacactgaca gctgctcatt gtgtgtaacg ccttcgataa tctgcgcaag 2289901 ctcctcaaag cttctgccgc attctgatcc ttttccagcc attgtttcta atgcaatctg 2289961 gacattttga ttcggatcaa tcacttcatt taagccttca ataatttttt tgatgccggc 2290021 ttcagctcct gcccctacgt gagcgccagg atgaaggaca atttgcttcg ctccgatggc 2290081 cgctgtccgt tcaatttctg aacgaagaaa atcaacaccc agctcaaaag tggacggatt 2290141 tgtcgtgttg ccaatattaa taatataagg cgcgtgtacg ataatctcgt caatgccgtt 2290201 ttcttgcata tgtgcccggc ctgcttctat atttaagtct tcaattttct ttcggcgcgt 2290261 attttgcggt gcgcctgtat agatcataaa cgtattcgcc ccataagaga ctgcttcctg 2290321 gcttgcagcc agaagcatat gttttccgct catagagacg tgtgagccta ttctcagcaa 2290381 caggttcccc tactttcttt tcttagattg gtttcttctc tgttttttct tgattttctc 2290441 catctcatag ctcattttct ttttataccc aggcttaacc ttcttcggct ttttcacgag 2290501 acgatgagca atttcatccg cttcattcgg cgttttttta cgttttttgc ggcgctgacg 2290561 gtcatcgcct tttttccatt cgcccttttc aagctctaag tactcaaatt cgatgcccat 2290621 tttttcaagt cttactaatg catcctcatc agtaagctca taaatggtca tcgcttgtcc 2290681 tgatgagccg gcacgagccg ttctgcccac acggtgaaca tagaaatcga gatcatccgg 2290741 cagctcatag ttgataacat ggctgacacc tttaatatca atacctcttg cggcaaggtc 2290801 agttgcaatg atatatgtga attccaaatc attgatctgc ttcatgactt ttttccgctc 2290861 acgtggtgtt aatccgccgt gcagcaagcc gattttcatg cctttgccag tcagatactg 2290921 ggcaatatgg tcagccgtat ttttcgtgtt ggcaaacaca atccccaggt atggattcag 2290981 atgcgacatg atgtcaaaaa ggagcttgtc cttgtcacga tgtttcgaag gaatgaggat 2291041 atgctcgatt ttcgcagcag tcacctgttt tggctccaca tgggcgtatt tcggattttc 2291101 catgtatttc ttcaagaatg gtttcagctt ttccggtatg gtcgctgaga acacaagcat 2291161 ttgcagatcc tcaggcatgc gggaaccgat gtaatctaca tctgcaagga atcccatgtc 2291221 cagcattaaa tccgcttcat caataacaag agattccgct ttatgaacac ttaacgcctg 2291281 ttctttgatt aagtcagcaa tccgtccagg tgtaccgaca acaagatgcg gctgtatttt 2291341 caatttatca attgattttt gtttatcagt gcctccgata aaacatttcg agcgaatctg 2291401 acttccttct tcaccctgcg tgattttaag cgcttcctga taaatctggt tggcaagctc 2291461 tcttgtcgga gccgtaatga ctacctgaac gacatcctta gcaggatcga ttttgtttaa 2291521 taaaggcagt aaataagcgt gagtctttcc agtacccgtc tgagactggc cgatgacgct 2291581 ttcttttttt aacactgcag gaatcagcct tttctggata tcagtcggtt cgtaaaaacc 2291641 aaggcgatgt actgcatcta taataaatgg tttcaattca taaagttcaa atttcgtttc 2291701 tttcattttt cccagctcct taaagcggca cattatgtgt ccatcatcac attatacccg 2291761 attttgctta aaaacaccac gtttgcaagg cgtttgtttt attcagttat gtaaagcaaa 2291821 taccgcagcc catgcatatt ctaatagcag agagagctga aaggaggtac aagtatgttt 2291881 tcaccgcagc agccaatgag aaattaccca cagcccggac cgccccgccc catgccaaat 2291941 cagcgaatga tgggcagaag accgcctaat atgcgaggac cttcatttgg agcacagcag 2292001 caaggttttc agcaagccgg acaatttctt cctcaggcaa atgccggagc gagaaatggt 2292061 gcaggtgcag gcggaggctt aaaaggaatg ctgtcaaggt tcctccccgg cggaggaggc 2292121 gctggcagcg ccggggttcc cggaattcca ggagcaggtg cagcagcgag cggaggtgct 2292181 ggcctgcaag gcattcaaaa tattgccaat cctgcatcat tatccagtat gcttggaaat 2292241 gtgcaaaaag tactcggcat ggcgcagcaa gtcaccccta tgatccagca gtacggccca 2292301 ttagtccgca atctgccagc aatgatgaag ctgtacagcc aattaagtaa aagtgatgat 2292361 actgagacag aggccaatga ggaaagtgaa aaacaatccg tttcagaaga atcatcagaa 2292421 aaagaaaaag agactgaaac aaaaacctca gatgggaaca aaaaatcaaa accaaaaagt 2292481 tcttctctcc caaagaaatc taaaacaact gacaataaag aacaagaatt aaaaacatct 2292541 gccccgaaga aaaaggaagc tgcctctcct gctccgaaaa gaacatcagg cagttcaaaa 2292601 ccgagattat atatttaaca ttctttgata tcttaagtga gattggctat aatgagatca 2292661 gaagaatgca agaatagagc cgtttgatta cggcttttta tattgccttt actcacttca 2292721 gtattggagg acaaccgaaa atggacgtaa ttaaaatttc accgcgcggc tattgctatg 2292781 gtgttgttga tgctatggtc attgccaaaa atgcgtcgct agataaaagc ttgccaagac 2292841 ccatctatat actcgggatg attgttcata ataaacacgt cactgatgcg tttgaagagg 2292901 aagggatttt tacattggac ggctctaacc gtctggacat cttaaagcag gttgacaaag 2292961 gaactgtcat tttcactgcg cacggtgttt ctcccgaagt cagaagaatc gcagaagaaa 2293021 aagggttagt cgcaattgat gctacatgtc cggatgtgac aaaaactcat aatctaatct 2293081 tagagatgaa agaaaaagga tatcacgtga tctatatcgg caaaaaaggg catccagagc 2293141 ctgagggagc cgttggcgta gcgccggaga tcgttcactt agttgaaaca gaagaagatg 2293201 taaagaacct tgatatccaa tctgagaagt taatcgtgac gaatcaaaca acaatgtctc 2293261 aatgggatgt tcacgacatt atggagcttg tcaaagaaaa atatcctcat gtcgaatatc 2293321 accaagagat ttgcctcgct actcaagtgc ggcaggaagc tgtatcagag caggcaaaaa 2293381 aagcggactt aacaatcgtt gtcggagacc cgaaaagcaa caattcaaat aggcttgctc 2293441 aagtgtcaga ggaaatagcc gggacaaaag cataccggat cggcgactta agcgaattga 2293501 agctcgaatg gctgaaaggc gttaataccg ttgcagttac agcgggagct tcaacaccga 2293561 cgccgatcac aaaagaagtc attcgctttt tagagcagtt tgatcacgaa gatccatcaa 2293621 cttggacaac tgaacataat ataccgctca aaaaaatact tccaaaagta aaagcaaaaa 2293681 actgaggctg taaaagcctc agttttttta tagaaatgta aatggatttg tatctgtttc 2293741 agaaacaaag atattcacgc caaacttttt atcattacac attgatgtaa gttttctcgt 2293801 gacgccttct ttcatgattt tttccgcgta atggcccgga tcaaccacat ttaggccaag 2293861 catcatcgca tcatgggcca catggaagta taaatctcct gtgacgtaaa catcggctcc 2293921 ctttcgtttt gcatgatgaa tatacttgtt tccatctccg ccaagaacag ctactttttt 2293981 caccatgctg tcagcatccc caaccattct gacaccattg acgtcaagct tgtctttcac 2294041 aaataaagcg aattccttga gcgtcatctc atttttaagg gttccgacac ggccgagccc 2294101 tttttcggcg ggagtctgtt cgacaggata gatatcgtaa gcgacttctt catatggatg 2294161 gctttttatc attgcattga taacagcctt ttcgacgctt ttaggaaata cagtctcaag 2294221 ccttacttca tgaacaagct caagctctcc cacttcaccg ataaaaggct tagctccgtc 2294281 caatggctta aagctgccga ttccttcaga tgaaaacgcg caatggctgt attcaccgat 2294341 atggccggcc cccgcatttc cgagcgcggc tctgacctgc tcttcatatt ccttcggcac 2294401 gtaaactgcc agctttttca gaggatccgt ataagtaggt gccagcactt ccgtctcact 2294461 cagctctaat gcttcagcaa gcaaatcatt cacaccgccg tccgcaacgt ctaaatttgt 2294521 atgagctgca taaacagcaa tatcatgctt caaacacttt tcaattaacc ttccggcagg 2294581 ctgatctgtt gaaatatgct ttagcgaccg gaaaattggt ggatggtgtg caataatcaa 2294641 gtcaacctct ttttcaatcg cttcatcgat aacgctctct aacacatcaa gtgtaaccat 2294701 cacattttta attggtttgt ttaaggtgcc gatttgcagg ccgattttat ctccttcaac 2294761 cgcataggct ttcggggaaa attgttcaaa cagctggatg atctgctgcc catttacact 2294821 tttagccatg atcgattacc tcctttaaca gctccattcg atcggcgagc tcctttaatt 2294881 tttgtttgtt ttgctctgta tccgccgctt ggctgatctg ttcataaatg ctttgagtgt 2294941 gctgaagctc ttgtgtccac tttttcaaaa agacagcatt tttttctttt gccaagaaag 2295001 ggccaacgag catcccggct gataaagaaa taccgtcata agccgcatcc ctgtctcccg 2295061 cttctgccac cagcacctca tagcactttc cgtcctcttc aaggattacc tcatctatca 2295121 gcgcatatct ttctttataa agccactccc tgatatgaac agcatgaata ttcggctgta 2295181 aaatgagccg ttccttcccc gttaatttgt ctttgcccgc ttctaaaatg tgagcgatca 2295241 aagccccgcc cattccggca atcgtaatgg catcagcttc acctttttta atcacttcca 2295301 gtccgtctcc ctgccttaca gaaatgtgcg agtttaagcc tgatttttca acctgccgct 2295361 ttgcagacaa aaatgggccg tctgttattt ctccggcaat cgccccgctg gctttatgat 2295421 tcagcaccgc ataacaagga aggtaggcgt ggtcagagcc gatatcggcc atcaccgctc 2295481 cattcggtat gtactccgct actgtttgca atcgtttaga taattttaat tcgttcactt 2295541 gtcatcacaa cttttctcaa tcattttttc ctttactatc atataaaaaa tcagcccgga 2295601 atccaagctg aagcaaatga ttttgaaatt atttcttttg atgcgggtct gcacgcagca 2295661 gtcaaaaata aaaggctgtc gagaacatct cggcggcctg tgaatgtata aagagaaaaa 2295721 tagttctttt atttaatttt tgacacccac tctgccatat catccagctt atcggccgga 2295781 acaagaccgg aaggcattcc attaccgcct ttttcgatct ttgttttaat ttcagcgaca 2295841 tctttcttat cccctacacc ttttaagcta ggacccgaaa caccttcata attttcaccg 2295901 tggcatgcga tgcagtttgc cttgtaaatt tcttctggtg aagcgtttgc atctttcttt 2295961 tcagcagatt tgctttctcc tccgctcgca atctcccgag agtcatcaag tccttttact 2296021 gataaaaaga aagttagacc aattcctaaa acagcgatca gcaaaaatgg aataagcggg 2296081 ttccatttca tttcccttcc ccctttttga tccttccccc tatgtaaaca cttctaattc 2296141 taacttattt ttacaaaaag taaatggatt gctatacaaa agttttttat tcacacttta 2296201 tacaaaattg aatagaaaca tgcctaaatc tctaatatcc tttttattct attgtataat 2296261 gtattgtata cgcttacaat agaaaatatg gaattagatt ttgaaatttt tcaccacaat 2296321 gttcatttgc aaatgacatc atttttcagt aaaataaagg catattatcc atatatcttt 2296381 ttaaaaaaag aagaacggat cttcaagacc cgttccatct tattcaagga aatctttcaa 2296441 acgtttactt ctgctaggat gtcttagttt ccgcaacgct ttggcttcga tttgtcgaat 2296501 acgctctctc gttactccaa atactttgcc gacctcttct aatgttcttg tacggccgtc 2296561 atcaagaccg aatcgaagac gcaatacatt ttcttcacga tcagttaacg tatcaagcac 2296621 atcttccagc tgctctttca atagctcgta tgcggcgtgg tcagaaggtg aagttgcttc 2296681 ttggtcttca atgaaatcac caaggtgcga gtcatcctct tcaccgatcg gtgtttccag 2296741 agataccggc tcttgagcaa tctttaagat ttcgcgtact ttttcaggcg ttaaatccat 2296801 atcttccgca atttcttcag gtgttggttc tctgcctaag tcttgcagta attgacgctg 2296861 cacacggatt aatttattaa tggtttcaac catatgaacg ggaatccgga tcgttctcgc 2296921 ctgatcggca atggcgcgtg taatcgcctg tctgatccac cacgtagcat acgtactgaa 2296981 tttataacct ttgcgataat caaatttttc aacggctttc atcaggccca tgtttccttc 2297041 ctggatcaga tcaaggaaca gcataccgcg tccgacatac cgttttgcga tactgacaac 2297101 aagccgcagg ttcgcttcag ccaatctgcg tttagattct tcgtcacctt cttcaatctt 2297161 ttgagcgtag gcgatttctt cttttgcaga aagaaggtta acccgaccga tttcctttaa 2297221 atacatacga actgggtcat tgattttaac gccaggcggt acacttaggt cattaaggtc 2297281 aaattcttct tcggctttgg caagctgctg aatattagga tcttctgttt cttcattctc 2297341 actaattaat tcaacacctt gttcacctaa aaattcataa tactcatcca tttggtctga 2297401 ttcaatttca aagctggaca tacgctcagc aatttcttca tatgtcaaaa cgccacgttt 2297461 tttaccagac tctgttaatt gctcttttac ttggtcgaat gttaattctg tctcgtgggt 2297521 ttgtttatca gccattatgg atccctcctt ccaaagcttg caacgaattc tataagcggt 2297581 atgattctta ttcggtccat tcaggcgttt tctatgtgaa ctgcctttaa caatgtgcga 2297641 ataatgaaat gacaattcat gatgaggtta agcgatctat ttgctcctcc gcaaggaatc 2297701 attgccaata aatgctcctc atcagttctc cagttatttt aaagatcggt tcaatgtaac 2297761 gatttcttga gccaaagaag cagctcttaa aaaatctttt tgcctttctg cttcggctct 2297821 ttccgcctct ttttctttta tcattgacca atttctttga ttcaacactt tttttacata 2297881 atctgataac tcggcttcgc taagctcttg attaacctga agcattaata tatcggacaa 2297941 gagctggctt atatgatcat ccgtcaccct ggccatcaga tgctgaggcg tcagctcggc 2298001 tccctcttca taaaaagcat aaagataagc ggctaatgcc cggtgctcat caatattaaa 2298061 ttgaaaccct acccggtcaa tcactttttt gatgacgctc cgatctcgaa gcatgtgagc 2298121 gagtaacagc ctttctgcat tttcatacgc cggacgcaaa cgtttttgcc ttgcttttgt 2298181 cgtcagatgc gctcgccgcg ttttagtttc accgctattg tcagcaggtt tgttttgctt 2298241 gctgaaaaca gacagctgct cagttaaaga ctcctgtgaa agcgaaaact ctgaagcaag 2298301 ctgctttaca tagacttcct gctctagaga ccctgaaagc gtgctgattt ctttcagtac 2298361 gtctttaatg taagctaggc ggtcgccttc atcggacagg ttctttcctt ttcggaaata 2298421 ttgcattttg aacgccatta cggtgacact tgcgtcaata atgtcgtttt taaatttttc 2298481 cccgccgaat tttttgatgt aatcatcagg gtccaatccg tcaggaatca ttgcaactct 2298541 gactttgcag cctttttttt gcagaagctc cgaagctttt aaggtggctt cataaccggc 2298601 tttatcagag tcatagcaaa gaatgatttc ttcgacgttt cttctcagga tcttgacatg 2298661 atcatctgta agagacgttc ccatcgtggc tatgctttcc tttacatccg agcttacggc 2298721 cgatatgaca tcagcaaacc cttcaaataa gactgctctt tcctgctttc tgatatgaag 2298781 gcgggcctta taaaaattgt aaagcagttt gcttttatga aagagcgggg tttcaggact 2298841 gttcatatac ttaggctgct ggctgccaag agccctgcct gagaaagcaa caacagcccc 2298901 gtgatgatca tggatcggaa acatgacacg gtttctgaag cggtcgaaat atccgcttcc 2298961 gtcttcgcgt ctgatcagga gacccgcttt ttccatttgc gcctcactaa atcccctctt 2299021 tacaaggaat ttcgtgataa agtcccaaga atcaagagca tagccaatct gaaattcatt 2299081 aatcagctct ttcgtaaagc ccctagaaag cagataatcc agtgcctctt gaccttcttt 2299141 tgtatttatt aacaaatgat ggtaaaattt cttcaggagc tcatgtgcct cagccatttt 2299201 ttgttctcca gaagactctg gccgggctcc ggaatggact gttatatcat ctggaaaatc 2299261 aatttggtat ttgtcagcaa ggtgagaaac cgactcggca aaagaatagc cttccatctg 2299321 ccttaaaaaa gagaaaacat tgccgcccgc tccgcagcca aagcaatgaa aaatctgttt 2299381 gtcgggcgat acggaaaacg aaggtgtgct ttctccatga aaaggacaga gtccaaagta 2299441 gtttcggcct tgcttcttta attgaacata atcacctatg acttcaacga tatctgccga 2299501 cttttgcacc tgatccacaa tttcatctgg tatccgattt cccatcttat aacactccgt 2299561 cgtacattat tcgatgcttt agtgcaaaat cccttcatcg ttcgacagga ttttttgcag 2299621 cagtgtaata aatcgttctc gatcttcttt attcaatttt ttaggccctt tggcatatac 2299681 gccttttctt ctttgtttgc cggaaaaatg acggccctct agggcaaaat caatcgtgtc 2299741 ttccttgtaa agacgacctc tttccgacat aacagagaca tttctgttca acagcagaga 2299801 tgctaatccg atgtcctgcg tcacaacaat atctcccggt ttcacgtgat ttgcgatata 2299861 taaatcagca gcttctttat gaggatcaac atacttccat ttttcttcat tgcttctgga 2299921 aagctgataa tgttcaaatg aagcgacaaa aagaacttga acttcatact cggatgctgt 2299981 ttgtaaaatt tcatctttta ccggacaagc atcagcatcg acaaaaatcg tcttttcttg 2300041 ttcattaaga agagtaattc tccatccctc cattaaactc ctgcataaaa gcaagcaaaa 2300101 tcgcacatcc tttattattg tggatgtata tgaatttgtc gaaaaatttc cgggagaaat 2300161 tcttgacatc ttacccataa tagtttattc gtatcacacg atccttaaac ctaaaattaa 2300221 tcattttatc acaatttttt attataatac aaacttcaca aagatgctat tgtttttcat 2300281 tattcccttt tggcacagcc aaaaacccag gatagagcgt cctgagttat atgttttttg 2300341 ttttgagatg atggataata tttgctgttt cctcaaccgc tttatttgaa acatcaacaa 2300401 cctggcagcc gatccgatcc acaatctttt cgaaatactc gagttcctct ttgattctgt 2300461 tgatatttgc ataaatcgct ttatcattaa gcccgagtga ttttaaacgt tcttttctga 2300521 tatgattcag tttatcaggg ctaatcttta aaccgatgca ttttttcgga tcaacgttaa 2300581 agagttcttc cggcggatca acctccggta caatcggaac attggcaacc ttcaggcgtt 2300641 tgtgtgcgag atattgagac agcggtgttt tagacgttct tgacacgccg atcaaaacga 2300701 tatcagcttt taaaatccct cttggatcac gtccatcatc gtatttaact gcaaactcga 2300761 tggcctccac ttttttgaaa taatcttcat caagctggcg cacccgcccc ggttcgtatt 2300821 tcgctgttaa accgtaggct gtttccattt tatcaatcaa cgggccgata atatcataat 2300881 ataaaacatt tgctttttcc gcttcggcta tcaaatattc tctgatttcc ggcaccacga 2300941 gtgtaaaaca gataatgccg ccgtctgcct ttgcaagtga aatcacttca ttgatagtgc 2301001 ctatatcttc aacataagga attcttctta catgagtatc atccgccgat ccgttaaatt 2301061 ggctgagtgc tgcttttact accaattcag ccgtttcacc gacggaatcc gatacaacat 2301121 agatgatgcg gttattcata ttatcccccc gttagtttgc aatcttatag gatttcattt 2301181 tcagataaac tgacaagtat tttggtcata tttgtttttg tcactctgcc gatcacttca 2301241 aagcctttat cggtgtcttt gatgacaggc agtgcatcaa tttgtttttc tattaagtgc 2301301 tttgcaatgt ccatcacata atcctcgcgt ctgcacaccg taatgttcgg catccttgtc 2301361 atgatgatgt gaacagggac cgatgtaagc tcctgctggc caatgctcgc tctgagcaag 2301421 tcttttcgtg aaagcacccc gactaaaaca gcatcgcggt ccaccacaaa cagagtacct 2301481 acatcttcta aaaacatggt gcaaatcgca tcgtacacag aaacgttttc gtgaatcact 2301541 acggggatag attgaaagtc tttcacctga agctttttga gtttatccgc caaaagctgt 2301601 gtgccggttt ttcccgtata gaaataaccg actctcgggc gcgcctcgag gaatcctgac 2301661 atggtgagta tggctaaatc cgggcgcaat gtcgccctgg ttaggttcag cttttctgca 2301721 atatgctccc ctgtaatcgg cccgttttct tttacaatct gcaaaatatg ttcttgccgt 2301781 ttatttagtt cgatcgtact caccaccttt tcacttcata gctatgtaaa gaaataacaa 2301841 tccatattat aacgtaaata tcttgtaatc aaacaaaaaa cttataaatg gggaaaagac 2301901 gattaccgat cacacagcaa ccgccttttc tctctttatt ttacaataag ggcattcata 2301961 ttcgcaaagg acttgatctc atccgccaag cttaccattt gcgctaaacg atttgccttt 2302021 aatgactcat tatccgctat aaccattgta tgatcgaagt aagcatcgat cggttctttt 2302081 aaggctgcaa gtgaagcaag cgccgcctca taatcttttt tgctgaagtt ttcctgcaga 2302141 ttttgcttcg ctgtttggta ggcatcaaac agttttgctt cgtattcatt ttcaaacaga 2302201 tcaggctgaa tgtctccgcg gactcctttt ttgctgatag agatcactcg gcctaacgct 2302261 tcggctgttt ccttaaagcc aggtgcacca agcttttgct ccagtacttg tgctttatgc 2302321 agcgcagagt acggctcaag ctcagagctt tccagcacgg cgtcaatgac atcatgtctg 2302381 atttgttcag cattcaagac atatttcaag cgctgagtga agaaatccag cagttcattt 2302441 tctttatcgg tttgaacgaa agtaagcagc tcttcaaatg aaattcccca gttgcggtca 2302501 agaagaatcg caacaatacc gcttgcttgg cggcgcagtc cgtaagggtc ctgggaaccg 2302561 gtcggaatta cgccgataga gaagaatgaa gcgattgtgt caagcttatc cgccattgct 2302621 acaacagctc cggtgaaagt agaaggcgtt tctccgcccg ctgatctagg catataatgt 2302681 tcattaactg ccgcagccac agcttcatct tcgccaagca ttctcgcata cttttcgccc 2302741 ataattcctt gaagttcagg gaattcatat atcatatgcg tcacaaggtc gaatttagaa 2302801 atttcagcag cccgcttcac atgttttaat gtatcttcat cagcctgaag acgaacggca 2302861 agtttctctg cgattgatgt gactctccta accttatcag caagagaacc aagctcttca 2302921 tggaaaacga tattttcaag cttcttcaca tttgcatcaa tgtttagttt ctgatcttct 2302981 ttgtagaaga atgaagcatc agataaacgt gcgcgcagca ctttttcatt gcctcgggcc 2303041 acattttcaa tcgcgtggct gttgccgttt cggactgtga taaagtgagg cagcaggtca 2303101 ccgtttttgt ctttgacagg gaagtagcgc tgatgctctt tcattgtcgt gacaagcact 2303161 tcttcaggaa ttgacagaaa ctcggattca aatgaaccgt aaagagctgt cgggtattct 2303221 actaaatgat tcacttcatc aagaaggtct tcgtcaactg gaatgctcca attgttttca 2303281 gcagccattg tttccagctg agattgaatc atttgctttc ggacgctagg atcagcaata 2303341 acatgctgtc ctttgagctg ctcttcataa gctgaaggtg attcaattga cacttcatgt 2303401 ccgaggaaac ggtgtccctg tgttgtccgt ccagactcaa cgtttgtgat cgaaaatgga 2303461 atgacatcct gtccaaataa tgcgacaatc catttgatcg gtcggatata acgcaaatct 2303521 tcatttcccc agcgcatgtt tttcgggaaa tgcaagcttg taattaaacc gctcaattct 2303581 ggcagaagcg acttcgtttc ttggccggct tggaattttt gcacgaatac atactctatg 2303641 ccttttactt ctttgatgta caggtcttcc acatttgcgc cttggccttt tgaaaagccg 2303701 attgccgctt ttgtccagtt cccgtccgca tcaagggcaa tttttttcgc aggccctttt 2303761 gcttcttctt ttatatcatc ctgcttttct gcgacatcct taacgaacac agcaagacgt 2303821 ctcggtgtat tgaagagttt cacttcaccg tgagtaatat ttttttcttt aagccagcct 2303881 gtcagcttgt cgccaagctg aaccatgctt tcattcaaaa agcgcgccgg catttcctct 2303941 aatccgatct ctaaaagtaa atcctgttta ctcatgagaa gaaccctccc ctttaagcat 2304001 tgggaaccct agtttttctc gttcctcata gtaggttttt gctacttttc tagctaaatt 2304061 ccgcactctt gcgatatagc ccgtccgctc ggtaacagag atcgcacctt tggcatcaag 2304121 caggttgaaa gtgtgcgagc atttcagcac atagtcatat gctggatgaa caagtccgtt 2304181 gtccatttgc ttgatcgctt ctttttcata tgtgctgaac aattggaaca gcatatcgac 2304241 gtctgatgtt tcaaacgtat aaacagaatg ctcatattca gccatcatga ataaatcttt 2304301 tactgtaaac cctgacgtcc attccaagtc aaacacgttt tctttatcct ggatataaga 2304361 cgcgagacgc tcaattccat acgtaatctc tacagaaacg ggtttacact ctaatccccc 2304421 gacctgctgg aaatacgtaa attgtgttat ttccattccg tcaagccaaa cttcccagcc 2304481 tagacccgcg cagcctaaag acggattctc ccagttgtct tcaacaaagc gaatatcgtg 2304541 ctcaagcgga tcaattccaa gagcacgcaa ggaatccaaa tacagctctt gaatgttatc 2304601 aggtgacggt ttaataatga cctggaactg atgatgctga tacagtctgt tcgggttctc 2304661 cccgtagcgg ccgtctgccg gacgtctgga aggctctaca taagccactt tccacggctc 2304721 aggaccgata ctgcgcaaaa atgtatacgg gctcatcgtg ccggctcctt tttctacatc 2304781 gtaagcctgc ataagcacac agccctgact ggaccaatgc ttttgcaagg ttagaatcat 2304841 gtcttgaata ttcatttcaa gcacctccac ttttctttca taagttgact gcggcagcaa 2304901 ccaaaaaact cccgtctcta tgcttgccag ccgcaaacat agggacgaga gttctcccgc 2304961 ggttccaccc tagttgctga gaacaaaatc ccagcctctt ttttaaaatt gctcaagaat 2305021 gcctttcgtt gcgtgctcat ccttagctta caccgcccta aggtcgcttt catgaggtaa 2305081 acgcaagtac ttctttctct cactgcaaca tattttataa taaatgatca tataaaaaga 2305141 tggaccaaat gtcaactttt gttttcaccc ataagatgtt tcatgctttc catttgatct 2305201 aaaaagcgct ttgattttaa atacaatccc gaatattctt cgtaatataa atcaatcact 2305261 tgctttaatt cagcttttgt ttcctctttt aaggacacat tgccgagtct cgacagatca 2305321 aaatagtaaa agagccttaa cagccttgcc gtttgcggtt taatcggtat cctgtaagga 2305381 tctttttcaa aacagcggtg gcatataaaa ccattatcac gaacagagaa atgaaaggtt 2305441 ccgtcttggc ttttacaatg tacacaatga ttcagctcag gatacaggcc catgacaccg 2305501 agcatcttca tttgaacaat gaaggtgata acatccggat ctgttccttc attcaactgt 2305561 tttaatgatt ctaatatgaa ttcaaataaa taaggatttg gctttttttc ttctgtgcct 2305621 ctgtcgacta actcagcaac ataggcagca tatgctgtta aaaacaagtc ttccctgatg 2305681 cctctcatgc tgaggatcat ttccccctgc tgaagcgttc cgaggcccga tgttttttgc 2305741 attaagaaag aaccatacaa aaagggctgg ctgactgctg ataaacggct gttcggtttt 2305801 ttggcgcctc gtgccataac acctattttt ccgtgttctc ttgtcagtaa tgttacgatt 2305861 ttattcgtct ctccgtaatc atttgtgcga agaacgatcc cttcacattt tgtcagcatt 2305921 tccgcacctt cctcaagcag gagcggccaa gaggtttata aaattggata atcaaatcgg 2305981 gctagctcat cttctagttc ttcgggtctt tccatgttct ctttttccag ttctttaaaa 2306041 agaagatacg tatcaacatt tcctgtttga gaaaatacgt tccaggtaaa attcaacaca 2306101 agaaacccac ctttctgtag ttaaactagc ttacctaaac tccaaattct tacctttatc 2306161 ttgaccagat gtcctccatt tcatgttaaa caaaatttgc taatgtatcc ctgttcctgt 2306221 gagataatga cacacacggg aagagattaa tattcgtcct ctttaaagcc aaaatcgcga 2306281 agctgggaca ttttattacg ccagtctttc tgcactttca cccacaattc aaggtagaca 2306341 cgggagccca acagtgcttc aatatccgct ctcgctcttt ttccaacctc ttttagaagg 2306401 cttccttttt taccgatcac gatgcctttc tgggaatccc gctcgaccac aatcgttgcc 2306461 gctacgtgca cagaaccgtt gtcctgccct ttgatggatt cgatggccac cgcaatgctg 2306521 tgcgggattt cttctctcgt caaatgcagc accttttccc tgattaattc agaaatgata 2306581 aatcgttcag ggtggtcagt tacctggtca ctcggataga attgcggccc ttccggcaaa 2306641 tacgcttcga tctgcgcgag caaggtttcg atgttatttc cttctaaagc agaaatcgga 2306701 acaatttcct taaaaggata acgtttgcgg tattcgtcaa ttagcagaag caattggtcg 2306761 ggatgaattt tatcaatttt gtttacgatt aagaatacag gcgtagacat cgtctgcaat 2306821 ttctcaatga tgaattcgtc gcccttcccg tagccttcct cagcattgat cataaacaag 2306881 atcaaatcga cttcttttaa tgtattttgc gccactttca tcataaagtc cccaagttta 2306941 tgcttaggtt tatgaatccc tggtgtgtca ataaaaatgg tttgtgatgt gcctgtcgtc 2307001 agtactcctt gcaccttgtt tctcgtcgtt tggggcttat cgctcatgat cgcgattttt 2307061 tgtccaatga ctctgttcaa aaatgtagat tttcctacgt ttggtcttcc aataatggat 2307121 acaaatcctg atttaaagct ttcgttcgtc atgtaaatcc tccgatgaaa atgcgcctgg 2307181 caataattct tccacagtca tttcttttat ttgtccttgt aaattagtca gtacgacaat 2307241 aacgtctttt gtgcaaagct cagaaatcac ctgtcggcag gctccgcacg gagatactgg 2307301 tccaggggtg tcagccgcaa cggccagcat ctgaaactct gtatcccctt cagaaacagc 2307361 tttaaataaa gcggtacgct cggcgcaatt gcacatgctg tatgccgcgt tctcaatatt 2307421 gcagcctctg tacacttttc catccttggt aagaagagcg gctcctactt ggaatttgga 2307481 atacggcgca tatgccatat cacgcgcttt taaagcttct gttattaatt cttgtctgtt 2307541 catgtgtaca ttcctctctt acctataatg gtaccgctat cactttatat tttacataat 2307601 cgcgcgcttt ttttcacgcc catttctaaa aatgtaaaat aaatgtaaga attttcagcc 2307661 attacagctt tggcaaaaaa ataagtaaac caatgataca cgaaatcacg gcaaaaacgc 2307721 aaacagcccc ggcggcagcg tccttggccg ctttagcaag agggtgatgt ttgtcagtta 2307781 ttaaatcaac cgtatgttca atggctgtat ttaaaagttc aagcgaaaac ataccaccta 2307841 tcaaaaggaa tataatcatc cactcaataa tgctgagctc tacaaggaag ccgcaaatga 2307901 gaacagcgca ggcggctgcg gcatgaaatt ggaaattccg ctccgtccgc gctgtttccc 2307961 atatgccccg gcctgcatgc acgaagcttt tgaagaatcg attcagctca tttctatgat 2308021 cttttgagtc cataagcgtc cagcaattcc ttttgcttag taaacatctc ctcttcttcc 2308081 tctttcgtca tatggtcata tcctaaaagg tgcagaaatc cgtgtacagc tagaaatccg 2308141 agctctcttt taaaagaatg attatactcc tctgcctgct ctcttgtgcg atcggcactg 2308201 atgataatat cacctaaaac cggaggcatt tcggcgccca cgatttcgat ctcgccttct 2308261 ccctcttctt caagagcaaa tgagatgaca tctgtcggag catcctttcc ccggtattct 2308321 ttgttaatct gatgtatgtc atcattggaa acaatcgtga cagaaacttc agcctgatcc 2308381 tgaacgcctt cacgctcagc ggcaaattga agcagatttt ctacttcttt gagcatctct 2308441 tctgagacgc ttcccgtttc atcaacgata tcaatcagta aactcatcta tttcaccttc 2308501 ttagtagcct ccggatattc aatccgggag tggaaaattc cttttaatgt tgcacagagc 2308561 gtttttgcga ttgtatccag ctctttaaat gtcaaatcgc attcactgaa ctgtccgtcc 2308621 tgaagcttat cggatataat accccggaca agcttttcaa ttcgttcagg atttggattg 2308681 tgcatggatc tgacggccgc ttcaacactg tcggccactg atataattgc ggcttccttt 2308741 gactgcggct tcggtcccgg ataacggaac tcttcctctg taatctggtc gcctttttcc 2308801 ttcgctttat agtaaaaaaa ctttaaaagc gaggttccat gatgctgctc agcaatatcg 2308861 acaagctctt tcggaaattt atagcttctc agcatattcg caccgtctgt cgtatgcgag 2308921 ataataatat ttttgctcaa ctgaggtgac agcttgtcat gcggattgtc aatattcatt 2308981 tggttttcaa taaaatattg cgggcgcttt gtttttccga gatcgtgata atatgcgccg 2309041 actcttgcaa gcaaaccatt agccccaacc gcttcacagg ctgcctctga taaattggca 2309101 accattacac tgtgatgata tgtacctggt gtttccgtca gtattttgcg caatagcgga 2309161 tggttaggat tagacagctc gagcagcctc atggtggata aaatgccaaa gcccgtctca 2309221 aaaaacggca tcagaccgat gatcaataca gatgaagcaa accccgacac aacccccatg 2309281 agcattaacg tgccgatttc aagacccgac agcgcagtgt tctggatcaa taataaggat 2309341 agaacgacaa ccatattaat aaacgccacg aaaagtccgg tctgcaaaat ctttgatctt 2309401 gcattgtgtt ttcctaaaaa taatacacct gaaatgccgc tgatcaaata ataaatccct 2309461 atgacataat tgaatgttcc tgtcacaccc tgattaaaca tcatacttcc gcaaatcgca 2309521 agaatgatac ttcccaaaat ggcaatgcgt tcattcatca gcagtttgat taagatggcg 2309581 ccggccgcaa tggggaccag atagccgata ttattatact ccatcttctg aaacaaactg 2309641 acaacctcca tgatcacaag caaaagtgtt gtgattatgg agaataacag aatggattgg 2309701 tttttaaact tcagattttg tttctgtttt tcaaaataat atacaagtgt tgcaatgaaa 2309761 agtccgatca taatcaatag cccgctgatc ggtttaaaga gatttgagtt atttaataac 2309821 ccggtcagct caagtttcct gtacacttcc cgatcaatga ggtcattttc ttccacgagc 2309881 acttgcccct gtttgatttg aacctgctgg acattatctg aggcttcctg ccgttttgcc 2309941 tctgttgctt tcggatcgaa gacgtaattc ggaataatag caaaacgccc gatttctgtc 2310001 gcggctccca agtatttaga cggaatagaa ttgctcttta gctctttttc taccttatcc 2310061 tttgcatcag atagtttatc cgaagggatt tcactgctca tgaccgtatt taccgcggta 2310121 atgaccgtat ctctgacaaa agaaaagtct tcactgtctg ctttcagcaa tgtcttgatg 2310181 gaatcctccg atatagaatc attcacatct gatgtcaatt tgtcctttac agatttgacc 2310241 attgattttt ccgatggtga tttactgcct tcttccgatg attttttcac ttcactaata 2310301 ctgtcgaata ttgatgacac aaggtcaatc cgattgtctg tatattcttt ttttaatgta 2310361 tattgatctt caaccgcgtc ctcagcggct tgcttttttt cctctgtggc tttttgatct 2310421 tctacggttg ccggagcgta aatggtcttg tcgctgactg aaaacaggtc taaatcaagt 2310481 gtttccggct taacatgtac aaagagcaaa gcaaacataa tggcagccag cagaagatac 2310541 agcagtacat gcatggagcg ggcattttta aaactgctcc atttttttga gctgcttttg 2310601 gtcttagcct tctttttcaa cacaagaacc tcctcttgaa acatcaagcc cataagcaat 2310661 cataaaaatg acccgataac gcgcgatcgg gtcattcagc attaattttg cttatcgtat 2310721 gcttcaataa ttttcgcaac aagcggatgt ctgaccacgt ctgtctggtc tagctcaatc 2310781 atagaaatgc cgtctattcc tttcagcatc tccttcgcta ctgcaagtcc cgatttgacg 2310841 cctttcggca gatcaatttg gctaacgtca cctgtaatga tcattttaga gccaaaaccc 2310901 agtctcgtca aaaacatttt catttgagca ggcgtggtat tctgtgcttc atcaagtata 2310961 acataagcat catcgagcgt ccgtcccctc atatatgcga gcggagcaat ttcaatgatg 2311021 cctctttcca tcagacgttc tgtatgatct gccccaagca catcatggag agcgtcatac 2311081 agcgggcgca aataaggatc tactttttct tttaggtcac ctgggagaaa accaaggctt 2311141 tcaccggctt ccacggcagg tcttgttaaa atgatttttt tgatatgtcc gttttttaaa 2311201 gcatggactg cttttacgac agccaggtac gttttcccgg ttcccgccgg accaatgccg 2311261 aatacaaggt cattccgctt catagcggcc acgtattccc gctgtcccat tgtttttaca 2311321 cggattgatt tgccttttgc gttttttgta atttcttctt catacatgct ttcaaagtat 2311381 tcaagttcat tcttctttgc cattttgatg gcgtaaatca catcacgttc agagatctct 2311441 atccccttgc gaattaaagc gaggagcgat cccagcagcc tgtctgcaat ctgaaacgat 2311501 tcatcatcgc ctgaaacata aatcgtctcg ccgcgcgtaa tgatatttaa attcagatct 2311561 ttctccatca atttcaaaaa agaatcttgg ttcccgaaga gtgaaagcgc ctcgtccggg 2311621 tttttcagtt tttgattcat cgcaagtaaa tgttctgtca ttcttcagtc tccctgacaa 2311681 taggtgtggt ttgaacgata tcttctataa cttggtagag aataatcaac tttactttac 2311741 cattctcaac agtctggtgc aaaacttttt cacttttcac ctcgccgttt tcgcctattt 2311801 tatcctctac atcctgttta cccaatttaa tgccttcttg aactgcttct tcttttgtat 2311861 attttcgcaa agcctcttca ctttctctcg tttgctcttt gacataggat acagggagct 2311921 taaatccgag aaaatgaagc gaatgctttt cttgttctgt ttttggatgc ttcaattcct 2311981 cttttttaaa cgtcatcccc cagatcggga ttgccaaaga accaaaagaa agcttgtgct 2312041 ttgtccttac tttgcccgta tagacgttaa ataatgtttc aagcgggact gtcacttctg 2312101 atctatacca ggtttctcca taaatttctg cttttgaggc gacttcctgc tgatggtctt 2312161 cgctgccgat cagtcccgaa acaagcagct gtcccttttc aacatgatcg tgtatggcgg 2312221 ccatgggctg tcctttttgc acaaacattc tcgtaatggt tgctttcttt ttggcgacaa 2312281 tattgcgcgg gctaacatat ttttcttttt cgggctcatt tttctccaca actttcatat 2312341 gaatggtcgt ccccttcaga tcaactccga cccaagtgat attgtctatt ccattggtta 2312401 atgatttctg tattttttcg ggcgacatca ttaaaaactg cagacggccc tttttgacgc 2312461 cgatttcatt aagatgctgc ctcatttgat gttctgtttc aggcttagcg cctgtcacat 2312521 caattttcca caccatattg gacagcaaaa acaaaagaat gaaaaaaatc gcaaaaccga 2312581 tcgtaaaccc tatattcagc tttgatttca gcaacaggaa gggaaatccc ttccgattga 2312641 taaatcgggc tttacattta aatttacttc ttacccgccg aaaggcatgt acatcctgaa 2312701 gctgtatata taacgatacg gcttctttct tttttttgac atgaaagacc ggaatcccct 2312761 gtcttgtgca ttcattaagg agccgctcaa tccctcttcc cgtcaattca agctggacct 2312821 tacccgaaaa aaaagacagc catttatttt tcacaacatt tccccctcgg ctttatgact 2312881 caacatatcg aacgacatca atcgtaccct ccaaaagtat ctcttccgga agaatcgcct 2312941 tgatgacaaa atttttacca gatatgatgc actggccctg cttcagcatc agccgcactt 2313001 cattctcact gaaaagcaaa aggcctctgt ggttttctat gtagatatga agtctgccaa 2313061 ccattgtaat cctcggcaga tccatcataa cgtccggggg aatttccaat gctcttgtca 2313121 gccaagcttt catacgattc tttctttgcc ccatacaaaa agaaccccct ttcatctcat 2313181 atgtatgatt tgaaaggagg ttctaacact ttaattttta cgggccgggc gcatcgtacg 2313241 gtgaggtttt ttcgcccgtg gaggtccgaa cacctctcct agaacgatcc cctgtacgac 2313301 ggtgtcttta ttcacctgaa gcattttttg ttttgtgtat actgtttttt gtttggcagc 2313361 agcaagatct cgttccagcc ctttcaggtt tcttgctgtt tccctgcgtc tttcttccgc 2313421 ttcccgtctt gcctgttcca tacggttagg gataggtgca ggggcatctt cttttgactg 2313481 cttcttttga ggagaagcag attgcacgtg ttgaggtttt tttctttttt ggctgttttg 2313541 cttttcttct ttgctctttt tgccgaaaat cgcagaaatg attccgatga tcgctgcaat 2313601 aataagcgga ttggtcagta aatcttccat cagcgttctc ccttcttaga gagattatga 2313661 tttgcggtct tcatccgaag ggtctttcgt cagcttgccg aatgaatcac gcatttctgt 2313721 gtcagcatcg atgttcttga tattcatgta atccatgacg ccaatattcc cttcacgcaa 2313781 agcttctgcc atcgcaagcg gcacttccgc ctcggcttct actactttcg cgcgcatttc 2313841 ttctacgcgg gcacgcattt cctgttcttg agcgacagcc atcgcacgtc gttcttccgc 2313901 ttttgcctgc gcgatgtttt tatcagcctc ggcctgatcg gtttgtaaaa ttgccccgat 2313961 gtttttgccg atatctacat ctgcaatatc aattgagaga atttcaaacg cagttcctga 2314021 gtccaatcct tttccaagga ctgtctgaga aatcatgtca gggttttcaa gcactttttt 2314081 atgattatca gatgaaccga ttgtagaaac gattccctca cctacacgag ctacaatggt 2314141 ttcttcccct gctcccccga cgaggcgctc gatattcgct cttactgtga ttctcgcttt 2314201 cgctttcact tcaatcccgt ccattgcgac gccggcaatg aacggtgttt caatcacctt 2314261 aggattaacg ctcatttgaa cagcttccaa cacgtcccgg cctgcaagat caatggcagc 2314321 acagcgctcg aatgtgagtt caatgttagc tcgctgagcg gcgataagcg cgttgacgac 2314381 tctgtcaaca ttacctccag ccagatagtg gctttcaagc tggtttgttc caacattaag 2314441 tcccgcttta tgcgctttaa tcagcgggtt aacaacccga ttcggaatga cgcggcgaag 2314501 cctcatccca actagagtga aaatgctgat tttcactccg gctgccaaag ctgaaatcca 2314561 aagcattaca ggcacaaatg taaaaaatac tgccaaaaca atgatcgcta ctgcgacaat 2314621 tgccagaatc ataagtgttg acggatccat ataacttctc ctcgtttcta tttaaatttc 2314681 tctcacgaca atgcgtgagc cttctacttt tatcactttt acttttttat ctttttctgt 2314741 aaacgatccc tccgatacaa cgtcaaggcg ttcatcatca ataatcacgg taccggaagg 2314801 acgcagcggt gtaaaggtta tacccacttt tcccattaag tccgtgcgcg tttgatttga 2314861 aacgtagccg ctctccgtgt ttgtagaatc atttaatatc aatttcttaa agaatttcat 2314921 acgctttccc aacacccttg tcagtaaaat aaaagctgta atcgaaacag ctgaggcgat 2314981 caagagagaa accgccatga cagtgaagct ccccgcggct aaaaacaggc tcgcaataat 2315041 cgctcccaag cccagtaatc caatgattcc tccgggaaga aaaatctcaa gcagaatgag 2315101 aatcacccct gctataaaga ggagaaccgt ctcatacccg gcaaggccgg ctgcaagatg 2315161 cccgtaaaag aacagcaata acgcaatgag tccagccgtt ccagggaggc cgacacccgg 2315221 ggaaaaaagc tctaccgtca gacctaaaaa agcgattgtc agcagaatag ggacaatgac 2315281 cggattcgtc agccatcttg ccgtcttttc cgcaaagctc tcctttgcat agctgatctg 2315341 cgccttttcg aacccaagct tctttacgag cgtggacaaa ttgtcagcag tgccttctga 2315401 atagcctacc tcaatcgcct tgtctgcgtt aagtgtcagc agatctccct taggcgcgcc 2315461 aacttccttg gcatctatat ctgggtcagc cattgcgagc gcatattttg gatcgcggtt 2315521 atttttcact gcggcatctt ccatctctgc cagccaaagt gattgagctt tttggtcagc 2315581 ggcattgcct tggccatcaa caatcgcggc ggctcccatt tttccgccag gcgccatata 2315641 aatgtgatct gcttgaagtg caatatatgc accagcagac aacgcgcgtt tgttgacata 2315701 tgcagttacg gggatctcgc tttcggttat caaatcggcc atatcaatag cagatttgac 2315761 caatcccccc ggggtattga tatcaagaat aatatggtct gcatgtgcat cctttgcgtc 2315821 ttgtaacgaa cgggacaaaa acgaggcgag accctgttcg acattttttt caaccgggat 2315881 cacataaaca gtttgttttt ctgcttttgc gttcagctgt acgcctaata aagaaagtaa 2315941 aaatataccc aaaagagcag cacggaatcc tttgatttga agcaagggcg gtgtatccct 2316001 ccttcctttt ataataagtg ccttctcttc atacgtaaca aatgtatcaa aggtttcatt 2316061 tttttatgta taaaaaaaga catctctctt agaaagatgt ccttttcttt gccatttaag 2316121 acagttgact gctcacaagc ttattaatta aacttccgtc agctttacct tttactttag 2316181 gcataattgc ccccatcact ttgcccatgt ccgcttttga gctcgcaccg acctccgcga 2316241 tggtttcatt tacgattgta cgcagctctt cttctgacag ctgctcaggt aaataaactt 2316301 ctaaaatgtc cagctctttt tgaactttat ctactaaatc taaacgatta gcgtttgaaa 2316361 attcctggag ggagtcttta cgttgcttaa gttcacgaga aaggacagtg agttcctcat 2316421 cctcggtcaa actgtctttc ttaagcttaa ttgcttcatt ttgaagtgaa gccttaacca 2316481 ttcgaacgac agtcagtttg tctttctcac ggtttttcat atacagcttc atatcctggt 2316541 tgagacgctc aagaagactc ataaatccac cctcttttag aatttgcgtt ttctagcagc 2316601 ttcagacttt ttcttgcgct ttacgctagg tttttcataa aattcacgct ttcttgcttc 2316661 ttgcaaagta cctgtctttg atacactgcg tttgaagcga cgaagagcat cttcaagcga 2316721 ttcgtttttt ctaacgaccg tttttgacat tctctttccc tccctccgaa tacaccaatc 2316781 gactaccttt aagttacaca tataaacatg tactttgaca ttataatata agccatcagt 2316841 caggtcaact aagtgagttc acttttccgt catgagtgcg actgcctgtc tatataatga 2316901 aagaaagggg ttggtgaata ggatgttaat tctgattagc tttactgctc ttatattatt 2316961 ctttctcgca ggcatgaaca tgcttcgaaa gggcttaatt tcaatggcgt actcaaaaat 2317021 tgaagaacgt ttgcttttat ttacagacca tccgttaaaa gcgtttctta tcagtattgt 2317081 atttacgggg atacttcaga gcagctcagc ctttatggtc attgtcatcg gctttgtaag 2317141 tgcgggcgtt ctttctttta agcggacgat cccgatgatt ctggggacaa atgttggctc 2317201 tacttttaca actgaattta ttgctatcaa aatggatatt gtgatttggg ttcttttaat 2317261 aggaggttta ttgttttttc tgactggcag gtatcctttg aaacagctgg gaacaagctt 2317321 ccttggactg ggcatcatct tcttttgcat cagcggattc agccatcttg ccgggccgct 2317381 gacaaagctg aaaacgggcg ccgacgttct ataccatgtt aacgattcaa actggtccgc 2317441 tttgctcatc ggcatggtgt taactgccat cattcactcc agttctgtct gtatcggcat 2317501 tttgatgagt tttatgaatg aagggattat cggactgaca caggcgatga gcgtcgtact 2317561 cggatcaaat atcgggacat gcattacagc tgtcatggct gctgtatccg gcggatatgc 2317621 ggcgaaacag acagcatatg cccatgtggt atttaacgtg ctaggggtgg ctctagtatt 2317681 gccttttctg accgcagcga ccggctttgt agagcagtta tcacctgatc ccgcacaaaa 2317741 gatcgcgcat ttcagccttt tatttaatgt ggtgacagct cttttatttc ttccgcttac 2317801 aaacttgttt taccgattga ttcaccttct tatcccggct aaataaaaaa atcggtacat 2317861 tttaatgcac cgatttttta ggttaagaag acaaacgcat gtgttcagtt atttcatcct 2317921 caaccacacg gacaaactgt ccttcgttgt aaggataacc tgcttttagg attttgactt 2317981 ttacgatttt gccgatcata tcttccgtac ctttgaaaac aaccttcata taattgtctg 2318041 tgtaaccgac aaacatattt tcttcttctg tttccttaaa cgcttcctca gggataatct 2318101 caagcacttc attttcatac tgagaagcgt attcttttgc aagctggtca gaaagagcaa 2318161 tcaggcggtg cacacgttcg tttttcacgt tttcatccac ttggtcttcc attcgtgcag 2318221 ctggtgttcc tgtacgctta ctgtaaggga aaacatgcag ctcagagaat ttatgttctt 2318281 taataaagtt ataggtttcc ataaattctt cttctgtttc tccagggaac ccgacgatga 2318341 catcagaagt aacagctaag cctggcagtg cttttttcaa tttatttaaa cggtctgcaa 2318401 agaattccat tgtatatttg cgtctcatcc gtttaagcac tgtgtttgat ccggattgga 2318461 taggaatatg caaatgattc actatcttat ctgagcggtc taagacctcg atcacttcgt 2318521 cagtgatttg gctggcttcg attgaagaaa ttctgatccg tttcacgcct tccacacggg 2318581 tgtctaattc gctcaaaagc ttcgcgaagt tgtaatcttt catatcttcg ccgtagccgc 2318641 ctgtatgaat acccgtaaga acaatttcct tatatccggc atcgacaagc tgctgcgctt 2318701 gtttaatgac ttcttcaggg tcgcgggagc ggagcaggcc tctcgcccac ggaatgatac 2318761 agaatgtgca gaaattattg cagccctcct gtattttcaa tgacgctctt gtgcggtccg 2318821 tgaaagcagg cacatcaagc tcttcatata ctcttgcttt catgatgttg ctgacgccat 2318881 taatcggctg gcgttcttct cggtattggt caatgtagcc aagcattttt tcacggtcct 2318941 gtgttccgac tacaatgtcg acaccgggga tcgccataat ctcagcaggt gaggtttgcg 2319001 cgtagcagcc tgtgacacag atgacaccgt caggattttg acgaatggcg cgtctgatca 2319061 cttggcggct ttttttatct cccgtatttg taaccgtaca tgtattaatg acatatacat 2319121 cagctgtttg ttcaaagtct cttctttcat agcccgcttc tttgaaaagc tgccagattg 2319181 cttctgtttc ataatggttg actttacagc caagcgtatg gaaagcaaca gttgccatta 2319241 ctgatcacct cttaataact ctgtttgata agaaatcgca ctcaacgcgt atagcggagc 2319301 ggtttctgtc cttaaaattc tcggtccaag gccgcacgtc acaccgtctt gctctgtgag 2319361 ccgttcaacc tccgcttctg ttaaaccgcc ttcgggacca aatacgatca atagagatga 2319421 tcctttcgga aggctgctta caatcgcgct gaatgcgctt atttcccctt gcttcgatga 2319481 ctcctcgtat gcaacgacac atttatcgaa atcctgcatc ctttgaagaa gctgctgaaa 2319541 agaatggaca tccatcactc gcggcacttc gttacggtac gattgctcag ccgcttcctt 2319601 cgcaattttc gtccatcttt cccgcttttt ctttgccttt ttgtcatcca gcttgacaac 2319661 agaacgcgcg gcttggaaag gaataaaggc atgagctccg agctcagtcc ccttttggat 2319721 aatccattca agcttatctc ctttcggaag gccgctcgca atatagacct ttatcggaag 2319781 ctctctgttt tcattcgtcc attctatcac aaggcaggac actttatctt tggaaacaga 2319841 ttgaagttca cattttgcct cgaagccgtc ttgagagcag cagataatct gatctccctc 2319901 attcattctc atcacgttca caatatgatg aacttcttcg ccggtaatcg aaaaagtcgg 2319961 cgcttcctct atttgctgct tcgtgagctc gataaaatat cgttgcatac gctgtgacac 2320021 ctactaactg ttattttttc gcaataatgc tgacccaatc ttccattgaa aggatttcta 2320081 caatggtaaa gccagcttgt tccagtgctt cttttacttc ttgtttttta tgaccgatga 2320141 ttcctgacgt aataaagtga ccgccttctt ttaacaggct gtacgcttgt gaagtaaagc 2320201 gaagaatgac ttcagccaaa atgttggcca caatcacatc atgttcccct tcaatcccgt 2320261 ctaacaaatt gttttgcttc acttgagcaa tatcgctgac tttgttcagc ttgagattga 2320321 ggcgtgcact ttctacagcc acgggatcaa gatcgtaggc atgaaccgat tcagcctcaa 2320381 gcattgcagc cgcaatactt aaaattcccg aaccagtgcc gacatcaatc accttatcac 2320441 ccttttgcac aaagcgttca agcgcctgaa tgcagagtac ggttgtcgga tgtgtccctg 2320501 tgccgaaagc cattcccggg tccatttcaa taatcagttc atcagtatgg accggcgtat 2320561 attcctccca cgtcggcaca attgtaaact tttcagaaat tttcacagga tgataatact 2320621 ttttccaggc agtcgcccac tcttcttcat ttacttcaga aatagtgatg tggtttctgc 2320681 ccaaatcaat attgtaaaga aggagattat taatcgtttc tttgatgccg tctacagttt 2320741 cgcccagaaa actgttaacc ggcagatatg ctttgacaat gacaccctca tctgggtaat 2320801 cattggggtc gagctggtag atttccccgt acacattctc acgttcttta attaaatcaa 2320861 gcgggtcctc tatcacaacc ccacttgcac cagcttcatg caatatattt gagataggtt 2320921 cgaccgcttc atgtgttgtg tgaatgctta attcggacca tttcaaaact accaactcct 2320981 catccaataa ttaatcgcct ttaaacgcgc gttttacctt gtcaaagaaa ctcatttcct 2321041 gttcgtcagg caggtttccg ctgacttcgg caaattcgcg gataatgtct ttttgtttat 2321101 cagtcagatt tgtcggcgta acgacgcgga cgacgatatg ctggtcaccc tgtccatagc 2321161 ctctgacatt ttgaacgcct ttgcctctta atctgaattt cgttcctgtt tgtgtaccgg 2321221 ccggaatttt caatttcact tttccatgca gcgtcggcac ttctacctca tctccaagag 2321281 cagcctgagc aaacgttaac ggcatttcac agtaaatatc atcgccgtca cgctcgaaga 2321341 actcgtgtgc gcgtacatgg aacacgacaa ataaatcccc ggcagggccg ccgtttattc 2321401 ctggttcacc ctgtcccgag agacgaagct gctgcccgtc atctacaccg gctggaattg 2321461 tcacattgat tttcttgcgt tttttgattt ttcctttgcc gccgcagtcc gcacatttgt 2321521 ttttaatgat tttgcctgta ccttcacagt ggtggcagac ccgtctgtta acgacttttc 2321581 caaacggtgt attttgctcc acgtttaact ggccggagcc tccgcagtgg gagcatgttt 2321641 ctggatttgt tccaggtttc gcacctgagc ctttacatgt ttcgcacgtt tcctcgcggg 2321701 gaatttcgat ggttgtttct ttaccgaaag ccgcatcctc aaacgacagg gtcatcgtat 2321761 actgtaaatc agcaccctgg cgcggagcgt ttggatctct tcgtcttgtg cctccgccga 2321821 atatacttga gaaaatatca tcgaaaccaa aaccgccgaa atcgccgccg ccaaaacctc 2321881 cgccgccgaa gccttggtta gggtcagtgt gaccaaattg atcgtaatgc gcacgttttt 2321941 ggtcatctga cagcgtttcg tatgcttctt ttacctcttt aaatttttca tctgatccgg 2322001 cttctttgtt aatatcagga tgatattttt ttgacagctt ccgataagct tttttaattt 2322061 catcctttga agcgctctta cttactccca gcacttcata gtaatcacgc ttactcatct 2322121 cgcttcactc tcccgaattt ctcacataaa ttagattgta tcattttgaa ttatgatttt 2322181 tcaattcctt ttatcccggg caagaaaaaa agtcaaagcc aagagatgcc tgactttgac 2322241 tttctaatca ttgaatcaga ttatgaaatg tgttcttttc ggtcagctcc ggaagcgggg 2322301 ctgacactaa aaagaactta ttttttgttt tggtcgtcgt ttacttcttc gtattcagcg 2322361 tcgacaacgt tgtcatccgc tttgccttca gcgtttgctc cgccttgagc ttgctgtgct 2322421 ttagcagctt cttcataaag cttcatagaa agctcttgaa cgattgtttg aagctcatct 2322481 tttttcgctt tgatctcttc aaattcgttt ttctcaatcg ctgcttttaa agcgtctttg 2322541 gcatcgttgg cttttttcac ttgttcttcg tccactttgc cttcaagatc ttttaatgtt 2322601 ttctcagttt ggaaaacaag ctgatctgct tcgttgcgga cttcgatttc ttcttttttc 2322661 ttcgcatcag cgtcagcatt ttcttccgct tcttttacca tgcgttcgat ctcttcatct 2322721 gagagacctg aagaagattt gattgtaatg ttttgttctt ttcctgtgcc taagtctttt 2322781 gctcttacgt ttacgatacc gtttttgtca atatcgaaag aaacttcgat ttgaggcacg 2322841 ccgcgcggtg ctggcgggat atcagtaagc tggaagcggc cgagtgtttt gttgtcggca 2322901 gacattgggc gctcaccttg aagaacatgg atatcaacag ctgtttggtt atcagcagca 2322961 gttgagaaca cttgagattt gcttgttggg atcgtcgtgt tgcggtcgat cagttttgta 2323021 aacacaccgc ccattgtttc gataccgaga gaaagcggtg taacgtcaag aagaacaaca 2323081 tcttttacgt cacctgtgat aacgccgccc tgaatcgcag caccaagcgc tacaacttca 2323141 tccgggttta cgcctttatg cgcttctttt ccagtttctt ttttgattgc ttcttgtacg 2323201 gcagggatac gagttgatcc gccgacaagg atgactttgt cgatttcgct tgcagaaagt 2323261 cctgcatctt gaagcgcttg acggacagga cccattgtgc gctctactaa atgagaagaa 2323321 agctcttcga atttagcgcg agttaatgta agttcaaggt gaagcggtcc tgcttctcca 2323381 gctgtgataa acggtaaaga aatttgcgta gaagatacgc cggaaagatc ttttttcgct 2323441 ttttcagctg cgtctttcaa acgctgaagc gccattttgt cttttgacaa atcaatgccg 2323501 ttttcttttt tgaattcaga caccagatga tcgatgataa cttggtcaaa atcgtcccca 2323561 cccagacggt tgtcgccggc agttgaacga acttcgaata caccgtcgcc aagctcaagg 2323621 atggaaacgt cgaatgtacc gccgccaagg tcgtatacta ggatcgtttg atcttcatct 2323681 gttttatcaa gtccgtatgc aagcgctgct gcagtcggct cgttgatgat acgttctact 2323741 tcaagacctg caattttacc agcgtctttt gttgcttgac gctcagcatc gttaaagtat 2323801 gcaggaactg tgataactgc ttttgatact gtttcgccaa gatagctttc agcgtatgat 2323861 ttaaggtgtt gaaggatgat agcagacact tcttgtggag tgtaatcctt tccttcaatt 2323921 tcaactttat aatcagtacc catatgacgt ttgatagaca taattgtgtt agggtttgta 2323981 atagattggc gtttagccac ttcccctact tgacgttcgc cgtttttaaa tgcaacaact 2324041 gatggcgttg tgcggtttcc ttcagcgtta gcaataactt taggctcgcc gccttcaagc 2324101 actgccacac atgagtttgt tgttcctaag tcgattccga taactttact cacttgaata 2324161 acctcctgct atgtaattat tgattcactt tgaccatgga agggcgaatg acgcgatcct 2324221 tcagcttata gcctttttgc atttcctcaa caacaatgtt ggagccgtag ttttcgtctt 2324281 cagcctgcat aacagcttgg tgcagattag gatcaaattc ctgccctaca gcttcgatgg 2324341 cttcgacgcc ttcttttttc aaggcttcta cgagctgacg gtggaccatt tccattccct 2324401 ggagcaaact tttcgtctgt tcattgtcgg cttcaacctg aagcgctcgt tcaaaactgt 2324461 caagagccgg cagcaaatca gtcacgatat tttgagaacg gtatttttgg gacgcttcca 2324521 tctctaaacg gctgcgtcgt ttatagtttt caaagtctgc ttgaacacgc aaaagtttgt 2324581 tttctttttc ctcaagcaaa ccttgcaatt cgttaatttg gttttgaaga agttcgcttt 2324641 catttgtttc ttcctgctgt tcatcagcgg cagcttgttc ttcaatgatt tcttgctctt 2324701 ctgtttcgtt ttgttcaacg gtttgttttt cttctgacat tgtgttcacc tccctcaaag 2324761 tgtaaggaga aggacaggtg ctgcccttcg ataaaatttg ccaaaattcc cttattcatc 2324821 atacagactt gttaatgctt ttgacaagtc cgaagtcaca tgctgaagca ggctgacaac 2324881 cctggaataa ttcatgcggg tcgggccgat aatcgcaatt gagccgatct gcttctggtc 2324941 tacggaataa gaagccgtaa tcagactgca attttccatc tcttcatagt cgttttcttt 2325001 tccgatttta atcgaaattc ccgtgtgcgg ggattgaacc agctttaaaa catcctgttc 2325061 tttctcaatt aatgaaagca gcgaccgaac tcgggtgata tcatggaact caggctggtt 2325121 cagcatattg attttcccgc caaaaaacaa cttttcaacg tgatttgtgg aatgaaaggt 2325181 tgaacgaagc gcgtcgagta tattgtcata gtttttaatg tgctgtctta ggtacatgac 2325241 aacttcttta aatatgcgct cattcagttc atccattgga acgccgctta aacggtcgtt 2325301 cagtatattt accagttttt caatatcaga cagatccatt ttggtcggaa agttaatcgt 2325361 tttgttttcc acatgccccg tattggtaac gagaatcgct accgccatat caggctgaat 2325421 cggaatgatt tgaatctgtt taaggtaatt ctcactcaac ttcggcccga gtacgatgga 2325481 tgtgtaattc gtcagatcgg acaaaatttg cgctgatttt tgaactgtct tctccagctc 2325541 gaaaattttc tctttgaaga tcgagtggat ttggtccagg tcgcttttcg tcaatttgac 2325601 gggtgacagc aaatggtcaa catagtaccg ataccctttt tctgacggaa cacgtcctga 2325661 ggatgaatgg gttttttcaa taaagcccaa ttcctccaag tcagccatct cgtttcttat 2325721 tgttgcagag ctaaatgtga tttcatcttt tttcgaaaga gttcttgatc ccaccggctg 2325781 tgccgattta ataaaatcgt tgattataac ctgaaggatc agcagctgac gatttgttaa 2325841 catcatcatc acctctgtta gcactctcaa taagcgagtg ctaattctat aacaaaagta 2325901 tcaaaccaca agaaaaatgt caattataac tcacccaaaa aagcgccaaa aacttcattg 2325961 cctaataatt tcccttgatg agtcaaataa acggcagact ccgaattgtg aatcagccct 2326021 ttttcagcga ggtcttttaa cacgcttggg aaaagtccat ccagggaacg gccgtatttt 2326081 tctgcgaatc gttttttgct gacaccggct gtttttctca aacctaaaaa catttcttcc 2326141 tcaatctgtt cttctgttgt cacttcatgt gtatctctgt acggaaaacc cttttcagct 2326201 atcaggtcaa tgtaatgctt aacaggtccg acgttcactg ttcgtgtgcc gccaatatat 2326261 ccgtgagcgc cagctccgaa accgaaatat tgttcgttgc tccaatacgt tagattgtgc 2326321 ttagattcca tgcctgcctt agcaaagttg ctgatttcat attgatgaat gccgtgagct 2326381 tccatcttgc tcatcactat ttcatacatt tcagcttcct gctcctgcgg cggaagatga 2326441 agccgccctt tttgcatcaa attataaaat accgttttcg gttctacaat aagggagtaa 2326501 acggaataat gctcagcgtc caatgataaa gcagtgttta tggaatgttc cagatgcttg 2326561 agggtttgcc ccggaagccc gaacatgaga tcaagactga tattctcaaa accgatttcc 2326621 cgcgctcttt caaaagaggt gaatacatct ttttgcttgt gcactcggcc gattttttct 2326681 aacagatcgt cttcgaacgt ttgcacacca aagctaaggc gatttacgcc tgcttctttt 2326741 aatattttta atttctctgc ggacaaatcg tccggattcg cttcaaccgc aaattccgat 2326801 aagtcgcttg agggctttag cacgcggttg atcatatcca tcagcttttt aagctgttcc 2326861 tcagacaggg aggtcggcgt gcctcctccg ataaagattg ttttgagatc aggctgcccg 2326921 gtttttgcta ttgtatttat catttcctgt tcgagtgcgt ttaaatactc gtcgactggc 2326981 tgactttgaa taaaatattt attgaaatcg cagtagtggc aaatatgctc acaaaatggg 2327041 atatggatat aagctgattt caacggattc accttcttta cagaaagaag ccgcagtaca 2327101 agactgcggc ggcttctatt gttttttcgg actgtcgtcc attttcagaa ctgccataaa 2327161 tgcttcttgc ggcacttcaa ctgagccgac ctgcttcata cggcgctttc cttctttttg 2327221 tttttcaaga agtttccgtt tacgcgagat gtcccctccg taacatttag ccaatacgtt 2327281 tttacgcatt gcttttatgg tggagcgggc cacgattttc tggccgattg cggcttgtac 2327341 cggaacttca aactgctggc gcggaatgag ttctttcagt ttttcaacga tcacttttcc 2327401 ccgttcatat gcgtaatcac gatgcacgat aaaggaaagg gcatcgattt tttcaccatt 2327461 cagcataatg tccattttca caagcttgga cggtttgtag ccgatcagtt cataatcaaa 2327521 ggacgcatag cctttagtgc ttgatttcag ctgatcaaaa aactcatata cgatttccgc 2327581 taatggcata tcataaatga tgctgacacg gtttgcgtct aaatactgca tatcaatgaa 2327641 attgccgcgt tttccttggc aaagctccat tacagcgccg acatagtcat tcggcaccat 2327701 catcgtcgct tttacgtatg gctcctcaac cctttcgatc ttttgaggat ccggcatgtt 2327761 ggacgggttg tcgacaacga ccttttcgcc gtctgtcata tacacgtcat agataacgct 2327821 tggcgctgtc gtaatcaggt cgatgttgaa ctcacgctca attcgctcct gaatgatctc 2327881 catgtgaagc atgcctaaaa atccgcagcg gaacccgaat ccaagcgctt gcgaagtttc 2327941 cgcttcatat tgaagggagg aatcattcag ctcaagcttt tcaagagctt cccttaaatc 2328001 attatacttc gctgtatcaa tcggatacaa accacagtac accatcgggt ttagcttgcg 2328061 gtatcccggc agcgcttctt ctgcaggatt ggcagcgctc gttattgtat caccgacacg 2328121 tgtgtcacca acatttttga ttgaggcagt caggaagcct acatcaccga ccgtcagttc 2328181 atttgtcgga gttgctttcg gcgtgaacac gcccacctct gttacttcga attctttgcc 2328241 ggttgccatc attttgattt tttgtcccgg ctttaccgtt ccttcaacga ctctgatata 2328301 agccacgaca ccgcggtagg cgtcataaag cgagtcgaag atcagcgctt tgagcggcgc 2328361 ctccggatct ccggtcggag ctggcacctt ttctacgatt tgttctaaaa tctcctcaat 2328421 cccgataccg gcttttgctg aagcaagcac ggcttctgat gcgtcaaggc cgataacgtc 2328481 ttctacctct tggcgcacac gttcgggctc ggcgctcgga aggtcgattt tattgatgac 2328541 cggaaggatt tcaagatcgt tgtcaagcgc taagtagaca ttggcgagcg tctgcgcttc 2328601 aatcccctgg gctgcatcca cgacaagaat cgctccctcg caggcagcaa ggcttcggga 2328661 tacttcatac gtgaagtcga cgtgtcccgg cgtatcgatt agatgaaaga tatattcttc 2328721 tccgtctttt gctttatatt taagctgaac agagtttaat ttaatggtta tgccccgctc 2328781 acgttcaaga tccatagaat cgagcaattg ttctttcatt tctcgttgag tgattgccga 2328841 cgttttttct aaaatacgat ccgctaaggt cgattttccg tggtcaatat gggcaatgat 2328901 agagaaattc cgtattctcg attgcctctc taaacgcttt tctttatctg tcacaatcta 2328961 tcactcctac tattaaacgc aaaatacact agcttagatt atatcaatag gattgtaaag 2329021 attcaatgta aaacaagaaa gagaaaagtt ccctatcata tctgggttgc ttttctcttt 2329081 cacgtactta ttgattcata tcccgtatcc attcatacat tgactgggca gtattggtta 2329141 cggtgtccga aagcgctttt ccggcttttg aaaacatatt gaatgtctcc accttttcca 2329201 gctctttttg tttttctact aaatcttttg ccgtgactgt ttctcctagg attgaggctt 2329261 ctttttcatt atcttttccg tcggtgagcg taaacgcccc cttcagtgaa gggtcatgat 2329321 agcctttcat actcagcatc ccgtggtttg cctgctgcat gccgaacaga acgcctaaaa 2329381 acatgatcgt gacaagcagt aagcactttc caaagtatgc aatcaaatca accacctatt 2329441 tcttattgtt ttttcgtctc cccgctcgct gcgttgacct tttcagcatc ccagtacatt 2329501 tcgctgaata cgtccgcggc cgcgttagcc gcacgctgca gctcttcgag attattatcc 2329561 actccgccaa actcgagcaa aagcgctcta tcggttaaat cctgattgta aacaccatta 2329621 tcgcctggcg agcctttgga aaagacacct gtgctaagtc cggggtattt tttctccatc 2329681 agtttatgaa gctcactcgc aattttatag ttttcttcga agtttttgct ttttttcccg 2329741 acgacaaagg ctaccctggc atagcttttc cctttaatcg ttgcggttgt gtcttttttg 2329801 cgccgagagt ctctgtggat gtcaatgata tattgcagat ttttgtttga agcgagggcg 2329861 tctttcacga ccggccttga ttcatcatag gacctggcat agtttaagcc ttttttattc 2329921 aattttgact gtatatcggt tttattcact gtggctccga ttccctggga ttcaagcgct 2329981 tgtccgaaca tatctcctac aagcgtgaca ttggctttag aatggcgcgc catgtcagga 2330041 tcggtctcgc cttttaatag agggagatat gattccgtat tgtgcgtgtg atagataaac 2330101 acgacctttt tatcacctgt tgtttgtttc ggcggatctt tttgcgcatt atctgattgc 2330161 gtttgctgtt tttcaatctc tgccaaattc gcttctcttt cttcctccat caccttagac 2330221 ggcggcggcg attccgcagg catattcgta taatccgttc cttgtccagc taacaaaatc 2330281 tcggtatcaa attgtgcaaa tcctggcagc tcccgaccga gaaagctccg cggatcttcg 2330341 aggttaatgc tcgtcgccag ctttaaagaa agacgagaaa gatgaaatga gctgtctgtt 2330401 tgagagaggt cagaagcgaa ataatggttt tccatctgca gcaaatgtgc aaatacgtca 2330461 cccggcaatt cttcagcaat cccataaaaa gagtcagacg acggcctaag ttccggccgg 2330521 agagacgtca gcacaccgga tagaacaaaa atcacgataa ggcttacgat aaatagaaag 2330581 atggctttta ccgctttccc tccatttacc gcaacaacaa tctgtctgtt tctgcgttta 2330641 tttctcattg aatccctcca gcgcttgtct agtaattact ctatgaacaa gctagaggaa 2330701 gtagaactgt ttagtgattg taggagcctt tgttttcttg tgacactttt tcatgaagcg 2330761 ctgtgtttaa tccgttcgct aaaacatttg ccatatcgtc gataaatgaa tcgacttcct 2330821 tcggtgtaac cattaagttg tgccctaaag gcgaaagcac ctcgtgaatg agctgccgtt 2330881 tttcatcttc ttgaagggtt ccgacaatac ctaggaacga ttggcgctgc ttttgatcgg 2330941 gaagatcgtc ttcagtgagc actttctttt tcccaaacgt catgcctgcc ggaacaagcg 2331001 atcttgatgg cctgttatcc ttcatttctc tgccaaaatg ttttaatatg tagtccaccg 2331061 tgtcgctggc aattgtcacg gcatcaacta ctgtcggaac accgatagca atcaccggaa 2331121 caccaagcgt gtctttgctt aaatcttttc gtttattccc cactccagac cccgggtgaa 2331181 tgcctgtatc cgatatttga atggttgtgt tgaccctttc caccgcccgc gccgccaacg 2331241 catcaatggc gatgacaaaa tcaggcttcg attgctcaat cacaccttta ataatgtcac 2331301 ttgtttcgat tcctgttatc cccattacac ccggtgcaaa agcactgaca ggcctgtaac 2331361 cctcctgtac gttttccggc tgaagcttaa acaagtgcct tgttaccaac agattttcta 2331421 ctgccatcgg tccaagcgca tcaggtgtca cgttccagtt gccgagccca acgatcaaac 2331481 agctcgcatc ttttgagata ttaaggtttt caagaaaagc tgagaattcc tccgcaaaga 2331541 cagcagagac cttctcctgc atttccgaat cattctccct gattccctgt gcttcaagcg 2331601 ttaaatagcg cccttctttt tttcccgaaa gctctgcgcc ttcctttgta acatcaactg 2331661 tgcggatttt aatgccgccg tgatcacgct ctttttcaat aaagccttta atttcttttg 2331721 tcggcacagc ctgctgattg gccattgctt ccttcgtttc cactgccaaa tcggtccgta 2331781 tcaaatactg attcacatcc agctcactct ttttcataca ggggcctcct tcacattaag 2331841 tacctatatt gttgccattt gctgaataaa tcatgctaaa aagagaacct tcaatgaaaa 2331901 atactttaca tttatattgc aatctaaagg tgtgtttgat agaatacaat ttgttctatt 2331961 gtgaagaaga tttaacctta agacactgtg ctacaggttg tatcttagga ggtgaaacac 2332021 atgccaaaca ttaaatcagc gattaaacgt acaaaaacaa acaacgaacg ccgcgttcat 2332081 aacgcgacaa tcaaatctgc tatgcgtact gcaatcaaac aagttgaagc ttctgttgcc 2332141 aacaacgaag ctgacaaagc gaaaactgct cttactgaag cagctaaacg tattgataaa 2332201 gcagtgaaaa caggtcttgt acacaaaaat accgcagctc gatacaaatc aagactagcg 2332261 aaaaaagtga acggactttc tgcataatat aaaaacgatc ctcaataatg gggatcgttt 2332321 ttttcatttc tttttaacag ctgtaaaagg aacagttcga gcaggagctg cttgtccttt 2332381 ttcccggttt tcatctcata gtccatgacg gcaagctgtt caataattaa acggagctcc 2332441 tcctctgaaa aaagccttgc ttgatccatc gccagcttta cccgaaatgg gtgaactttt 2332501 agattagaag cgatttgttt ttgtccgtat ccctgttccg cgaagtactt cgtctgcaga 2332561 atcagccgga actgattcga aataagcgcc ataattttga tcggttcttc attttgtttt 2332621 agcaaatcat aaaaaatttg cagactctct gttcgttttc ggttgacgat tttattgatc 2332681 agctcaaaaa tattttgttc aaggcttcta gcaacaagca tttttacatc atccagcgta 2332741 atttcttcac gatctccaat aaacgtgcag agcttttgaa tctcctgaaa aatcgatgac 2332801 agatgaccgt tcacaagcag aaccaaatgc tccgccgctt ccgtgccgat tgttttctgc 2332861 tctgtttttg caaggttgac agtaaagtct gtcgtttcct ttgcatttaa ttccttcgcc 2332921 tccatcataa acgcgtgctt ctttaacgct ttcgtcagct tttttcgctc atcaagcttt 2332981 tcatacggag caagcaggac aaagactgtg taaggcgcag gtgattgtat atatgattca 2333041 agcgcactga cgttgtgctc aattttttct tttttctttt cacctgttaa aaaatatgga 2333101 tttttcacaa tgacaagacg ccgctccccc ataaacggaa acgtttcagc atctgcaatc 2333161 gcttgatcca gcgggtcctc ttccagatca aaaacggaca gattgaaatc ctttgtctcc 2333221 tgatcaacga ccgtctgtct gatcctgctg acggtttctt gcagcagata tgtctctttt 2333281 ccgtataaac aataaaccgg atggacctct ccttttttca ggcttttcca cacatcaaat 2333341 accattgttg tacgacttcc tctctttcat catccccttc tatcctaaat tgagtttgca 2333401 aaatagtaaa gaggaagcct gactgctgct tccccattta tattaaacgc ctgttcgcaa 2333461 gcccccggga cagcttgtaa aaaggcgata atcaccagaa cagaaaacgt taccttagct 2333521 tctagatttt tcaaaacaat tccattatac ttaagtcagt caggagggat aaagttgaat 2333581 gattttgaaa aaaacgttca aagcaaacga aatgatgctg tagattcagc tgttggtttt 2333641 gttgtgtcct tcggattttt cgccttcttg tttgtcatgg caacggttat tcacctagtt 2333701 ggttcataac agcgactgcc cgggctgctg atttctcggc agtctttttt agttcgtctc 2333761 tgttatatct gatgtatcat atggaggata gacagaaaag gttccaactc tgtttttgta 2333821 tctatattgg atcgttccgt tttgatctgt tcgcagcacg cggatagaat gtctctgtaa 2333881 tagttgcaga actttttgat gaggatgatg gtaccgattg tttttcccgg ctgagataat 2333941 ggccgttttc ggctgaagct gttggatgaa ttcttcaccg gtagagcctt tgctcccatg 2334001 gtgccccacc tttaacacat ctgcttttat attcggaaac acgttcatca cctcttgttc 2334061 cccttctttc tccagatcac ccgtcaagat ccagctcata ccgcccgtct ccatccacag 2334121 aacgagagat gaattatttt tgcttgccgg atcaggtgct tccggtgaca gtacatggaa 2334181 ctgcaaatcc tttatttgca acacatcgcc tcgcttcacc tcttcaattg ccactccctc 2334241 ttccctggct gcctgcagca ctttctcatc tttaggttca gaaacgaacc ctttcggaat 2334301 cacgaggcgc tttactttat gatgcttcag cagaatctcc gcctctccga tatgatcttg 2334361 gtcagcgtgc gtcagaatta aagcgtcaag ctgcttgatt cccttagcag ttaaaaacgg 2334421 aatcagcacc ttttccccca gtgaaaacgg atgctgtttt tcgcgccaag gctctgacga 2334481 gtaagacaaa gtgccgccgg tatcaattaa gacacgaccc cgctgatgcg gagcacctac 2334541 aaacatgctg tcaccctgtc caatatctat catatccact tctccttcgg aactaagaca 2334601 cggatatata aagagcagaa acatcaccgt gcagcaaatg cctccggtta ccatcaactg 2334661 cgacaaggag cgtttttcaa tcgccataag caataggatg atcgtgactg tgaataaaaa 2334721 aagcaaaaca ggtgcaggat gtgcgatcat aatcgtgaac acatcaacat ctgcaatgtt 2334781 tgtgattaac ctattgatcc agcttatcaa taaatcaaac cagctgaaaa acaatctccc 2334841 aaacgaagcg gaaagactta atagaagaac acctgctaca gctcccggca aaatacagaa 2334901 ggtataaaat ggtaccatca acatattcat cggtacgctg atgatagaaa actgatgaaa 2334961 atgatatagg agaatcggaa gcgagcccag ctgagcgatg agtgatacaa ttgtcagctg 2335021 ccccaaggag gttttaacct gctgaaaaat agaagaggat agaattaaag aaaaactgac 2335081 ggcgaacgat agctgaaaac cggcttcaaa gagatgataa ggattgaaga gcagaaggac 2335141 gatgtacgaa aggcaaattg cagttgcaga gcggacacgc catttgacaa gacttccagc 2335201 taagtaaaca cccgacatga gagcggcgcg tagcactgaa ggagcagcgc cggtcaacat 2335261 cacatagagc ggcagaaata acagcaacag aattgacgcc ttttctctag ttataccaag 2335321 gcggatcatg atataaaaca aacctgctgt caaaatcccc acgtggagtc ctgatattgc 2335381 caagagatgg acaacaccaa gcttttgata cgcggtaagc acttcatcct ccacgtaaaa 2335441 tctgtcacca actgtaagtg cctgtacaat ccctgtcgaa tcaggaggca gaaggctgtt 2335501 tgtgaatgat atgatatgtt ttctcaagct gagcaccttg tacttgaaat tttcaggttc 2335561 gctgcagttt tggatagacg tgacagagta gttccaatga atatgctgcc gataaagata 2335621 ctcgttataa tcaaatgcac ccggcacagt tgcgtgattc ggttcttcca atgtaccagt 2335681 caactcacat gacattcctg gttctatgta taacagctgt tctttttcac cagcagactg 2335741 aatgcgatac gcagcagccc atttttcctt atcaggtgtc tcaaccatca tagacatacg 2335801 gtcgccgtca attttgggaa tagtgtcaat cactgccttg aattgatagg ttccctgccg 2335861 ataggaagag acattctgag aatctgtgac tgcatacagt acaaaaaaca atataaaaga 2335921 gaagaaacaa acaataataa gaaaagcgtg cctcgttttg attaaaatga tgaggagaaa 2335981 gaggatgaaa agaaaaatag cggggaaata agcggcggca gtaattccag ccgttgccga 2336041 agctgccgcc ataggcaata ataagcgcga attacgcatt catcacacgt agctcgtgaa 2336101 aagtgtattc gcctgttcat gtatcttttt caattcttcc tccgctaaac cggcatcagc 2336161 caatttccct attagacccg ctacaaatga aagcttttct ctgtttttca gatcaacgat 2336221 catttcatcg agttcaacct gttcaacagt tacacccgcc tgttcaaata attcctgcgc 2336281 atacggatgt gttttgtaat cctcagcata ataaaccgtt ttgataccag cttgaataat 2336341 agatttgcag cattgaatgc acggataatg cgtcacataa atctcggctc catcagtcgg 2336401 caccccaaac ttagagcatt gaagaatcgc attcatttca gcgtgaatgg ttcttgcgca 2336461 atgatcatct atcattaagc atccttcatc tgcacaatgt acgccgcccg cgattgaccc 2336521 attgtagcct cctgctatca tgcgtttgtc tctgactata gtagcgccga cagataatct 2336581 cggacatgtg ctgcgcagcg ccaataaatg gctttgagcc ataaagtatt gattccatga 2336641 aattcgttcc acgttgttcc ctccaaatgt tgtgttgcct gacctttagt ttacctatca 2336701 taatgcatga ccgtcaaatc actttactgt aatggaagac tttattttct caaatgactt 2336761 ttcacctatt cctgaaacct tagtgatatc ttcaattgtt tggaaacgac cgttttcctc 2336821 ccggtatgca ataatagctt cagctttgga tggccccacc cctgagatgc cttgtaactc 2336881 ctctaaggtt gctgtattga tattcaccag cgctcccttc cctccatcgc tttggacaga 2336941 ccctccgcca ccttgctgca ctgctgtttc ctctcccttt ttcgggatgt acaccactgt 2337001 cccgtcctgc agaatctccg ccaaatttac ttgcgcttcg tctgcttgtt cactggtccc 2337061 gcccgctttc tcaattgcct gagatactct gtcccctgtt cgcatttcat aaacgccagg 2337121 atgctgaaca gcacctttga tgtctatcac aattgtttcg tttgactcgt cgttgtttgc 2337181 ttcctgcttt accactgtat tttctgtctc tgttggtaca gcttgcttca ccggctcttt 2337241 atttttccct gtggccagaa agatcataat cgctgtgaaa acagccgcag aagccgctaa 2337301 aataattgct ttcttatgct gattcaacca attcatcgtg catgttcccc gctttcgtca 2337361 tattttattt tcataacaca tatggtttag aggataatag ctcaaaggag gggaaaccat 2337421 tgaagatagg ctttatcggc acaggaaata tgggtacgat ccttatcgaa tcatttattg 2337481 aatcaaaagc ggccgatccc tcaaacatga caatcacaaa ccgcacaatt gaaaaagcgt 2337541 tgcacataaa aaaccgctac aacagcataa acgttaccga aagtctcgaa aagctcgttt 2337601 ctgaaaacga gatgattttt atttgtgtta agccgcttga tatatatcct ttactggcaa 2337661 gagcgttacc ttatttaaga aaagatcata ttctcatttc aattacaagc cccgttcaaa 2337721 ccgaacagct cgaacaatat gtgccgtgtc aagtggcgcg agtgatccca agtattacga 2337781 acagagcgct ggcaggtgtt tctctcgtca ctttcggcac aagctgcggc gaatctgcaa 2337841 aagcgaaaat caatgagctg atgcagcata tctctcatcc gctgcaaatt gaaagtgaca 2337901 tcacgagggt tgcatcagac atcgtaagct gcggccccgc ttttatgagc tatctgattc 2337961 agcggtttat agatgcagct gtttcggaaa catcagtgtc taaacaggac gcgattttga 2338021 tgtgtaagga aatgcttgtc ggaatgggaa aactgttaga aaccgaattg tataccctgc 2338081 ctgcattaca ggaaaaggtt tgcgttaaag gcggtgtaac aggagaaggc attaaagcgc 2338141 tggaaagcgg tgtgcaggat atgtttcacc gggtatttca aaatactcat atgaagtacg 2338201 aggaggatat ttccgcagtg aaaaagcagt ttcatgtgta gacgagtatg tcatacgttc 2338261 gtctgtactg caaaagcata aaaaagcatt ttaaaaaacc atcgttttag gaaacgatgg 2338321 tttttgattt ctgcgccttg aaaaagaggc gttctgattg tgctgatggc tcggtatccg 2338381 taaaatcagc tgtcacgcga tggagctgaa agccgcagtt cttaagcatt tcttcgtatt 2338441 cttccaccgg gaacgttctt tgctcgtgtg tctcatcaaa acgatcatac gcttctccgt 2338501 tccacacaaa aaacgacata tcatgaatga cagaaagctc gtcacttccg gcaaagctct 2338561 gccaaatata gctgatatct tcgtcctggt cagcaaatgt gctatccgga aagacttccg 2338621 caattttaaa agatgaatga acatcaaaca gcaggatgcc ttcaggcttt aatacccgaa 2338681 aaacactttt aaaggtttcg atcacatcat tttttgtttt taaataattt aatgagtcac 2338741 agcatatcac aacagcgtca aattgaccgt caaagccggt aatctctctc atatcctgct 2338801 gaagaaataa aataggctgg ctactcgata ccttttgctg ggcgaaagaa agcatctctt 2338861 cgctgagatc gatgcctgta acctcgaagc ctttttcggc aagccggatg gagatttccc 2338921 ccgtgccgca tgccagatcg agaatacggc ctttttccgg gagagatgct tcaatccatt 2338981 ttgtccattg atcgtaaggc gcgtgtgaca ttagctcgtc atacacgctt gcaaagcctt 2339041 gataaatcat tgattcattc caaagtcaag atctgcgagc ggagcgtctc cccacagctt 2339101 ttcaaggttg tagtagcttc tttcatcctt gtggaagaca tggacaacta catcgcctag 2339161 atcaacgaga acccatcttg cttcatcaaa gccttccatc tttttgactt gaatgccgtt 2339221 ttcatcagct tgatccttga tttcacgggc aatcgcctgt acctgtttat ctgaatttcc 2339281 gtggcagatc agaaaataat cagcaaccag agaaatacct tccatatcca gtgctaaaat 2339341 atcctctgcc cgtttatcat cgcaagccgc agctgcgatc tttaaaatgg acttttggtt 2339401 cattcacaaa ttcctcctgt tcagctgcca gacacaagcc agttatacgt taaaaatgtg 2339461 tctggaaaaa ccggttgatt ttttttcata agaaaaacca ttgtattttt aatggactga 2339521 atcagcgctt gattcaaatc tgtctcagca agcttacgca cctcatcgac accgggaaat 2339581 gcccggtttg gctcaatgta atcggcaacg taaatgactt tttctaaaag tgtcatgccg 2339641 gggcggcctg aggtatgata cctaatggcg tcaagaatgt cttcatcttg aacccctgcc 2339701 tctctttgga ccaaataagc gccgaccgga gcgtgccaga gctccggatt atgatccaat 2339761 aaatgcgcag gcattttttc acgcgcaata atttgtttca tttcttcttt cgggcggaat 2339821 ttggcgtaat catgaaagat tgccgctatt tccgcttttt tagaatcggc tccaaaacgc 2339881 tccgcaagtt cgatcgccgt gttcatcacg ccaaccgtat ggatatatcg gtgttcggtc 2339941 aattgctgct tcacgcatgc aagtgcctcc tcacgattca tataaaccat tctcctctac 2340001 atacttcttc actttatcag ggattaagta gtcagtgggc ttcttgcttt taaaccgttc 2340061 ccttatcata gttgatgata cctcaaattc cggaacgtct gcaaagagaa gcggataagg 2340121 ggtttcaaca tgaaaaccgg ggcgctttac tccaataaat tgaatgaggt tcagcagctc 2340181 gtccagctta taccatttcg gcaaatattc aatcatatca gcgccgataa taaagaacag 2340241 ctgatcattt ggataacgct gcttcagtaa agaaacggta tcaaaggtat atgatggccc 2340301 ttctctttcc atttcaacaa gctccagctt aaaggacgga ttagattgaa ttgcaagctt 2340361 tagcatttcc acgcgatgaa agctgtcggt atagtcttcg ttctgtttat gcggcggaat 2340421 ttgattaggc ataaaccaaa tttcatcaag ccccgcctgg tacagcacct cattcgccat 2340481 taagaggtga ccattatgcg gagggtcaaa cgtgcctccg aaaattccga ttttcttcat 2340541 ttcaaccacc tttaaggaag ctcgatttgt ttattttcct ttgattcctt atataacaca 2340601 atcgtattgc cgattgtctg caccaattga gagcggcttc cttttacaag agcttccgct 2340661 acatcgtttt tatcctcttc gcaattctga agcacgctga ctttaatcag ctctctcgct 2340721 tcaagcgcct cagcaatttg tttaatcatg ttgtcgttta ctccgccttt acctacttga 2340781 aaaatcggcg ttaaatgatg cgcttttgaa cgcaaaaaac gtttttgttt acctgttaac 2340841 attctgttcc tcctaatttt cctattacaa tagatctcat tttttcaata ttaggctctt 2340901 gtccagtcca caattggaaa gacaatgctg cctgttcaac aaacatgccc acaccatcga 2340961 gtgttttcaa gcctttttgg cttgcttctt ttaaaagtgc cgtctgtatt ggattataca 2341021 cgatatcaca tacgacggca ctgctcgcgg cacgctgtaa tgaaagcggc acatcgtcca 2341081 cgttcggata catgcccaca gacgttgtat ggatgataac atcatactgc tcaagacgtt 2341141 cttctgcttc ttttatgctt aatacttctt tattgtgaaa cgagggagta gcttctgtaa 2341201 gccgctttgc tttttctaac gtccggttgc aaatgtcaaa ttttttcggg gtatttcgga 2341261 caattgttgt aaaaatggct ctcgccgctc cgccagcgcc gatcattaag aatgacagtt 2341321 cagagatggg cttgtctaat accttcatta atgacttcac gaagccttcc ccatcggtat 2341381 tgtatccgac aagcttatct ccctctcttc tgaccgtgtt tacggcaccg agcacttttg 2341441 cactctcatc aatatgatcc aaataatcca taatggaaac cttgtgcgga acagtcacat 2341501 tgattccttg tacgcctaga gctcttattc cttttaccgc atcctccaga tcattctctt 2341561 ctaccttgaa ggcatgataa tgtccgtcaa gcccgaggtc tttcaatgat gcgttatgaa 2341621 tatcaggtga catagaatgg ccaataggat ttccgataac cccgtacagc tttttcatac 2341681 acctctcccc ttttcttaaa ttaatgaacg ccgaacaaat acatgaacgc cttttggcgc 2341741 gtatgcagtt acctttttat cagcgtcatg gacagtaacc cagcctaacc cagagaaaac 2341801 gatatctgtc tttttgtctt ttatcgtaaa cgtatgggcg accaattcag gaaactcatc 2341861 catttcatct ttacccggag gtgtgagcaa ttcccctgca tgcttttcat aaagcgcgtc 2341921 tgcattttca agttttgttc tatgaatcat cagctcattc ggcatatagc aaataaaagg 2341981 agatctttcc ccagacacat aatcaaacct tgcaagtccg ccaaaataca gtgtttgctg 2342041 atcattaagc tggaatgtgc gaggcttcag ctccttttta ggagataata ttttcaggtc 2342101 ctttttattg acataatgcg ccatttgatg gttgttgata attcccggtg tatcataaag 2342161 cgatgaaccg tcatccagcg ggatttcaat cgcatcaagg gttgtgccag gaaattggga 2342221 tgttgtaata atatcttctt cacctgacac ttctttaata atccggttaa taaaggttga 2342281 ctttcctaca tttgtacatc cgacaacata gacgtctttt ccgttgcggt aatgctcaat 2342341 cgcgtcaatt acttctctga ttccctggcc gcgacccgca ctgaccaaaa atacgtcaac 2342401 cggttttaag ccaagctctt tcgcttcacg cttcatccat tggatcagac gctctctttt 2342461 cagtgactta ggcaaaatat ccgctttatt gccaactaat aagatagggt ttccccccac 2342521 caagcgctgc agcccattaa tccagctgcc gttaaaatca aaaatatcaa caatttttac 2342581 gaccagagag tccgtttctc caataccgtg aagaatgttc aaaaaatcat catcagttaa 2342641 ggagacatct tgtatttcat tatagttttt cagtctgaag caacgctggc aaatcacatt 2342701 ttctttcgta agcgatgcag gcggcgcgta ccccaaacct gttttgtcct cggtttggat 2342761 cgtaactccg cacccgatac aaacaacctt ttccatttct tactcctccc actgaatgtg 2342821 cccttttcgt ttgagagcac tcagtattct gcgttcgacc tggcggttaa agcgcgtaat 2342881 gaatccgtca gaggaagcga ctggcacgac caaaatcgta tggtagccgt ttcggtttcc 2342941 cccgagtaca tcggtcagca gctggtctcc gatgacaacg cagtcctctt ttttcagctc 2343001 catattgcgc accgctctat taaaggcttt acccatcggt tttcttgctt tatagatgaa 2343061 tgggattcca agcggttctg agaaaagttt cactcttctt tcgttattat tagagacaat 2343121 tgtcacttta atgccgtgtt ccttcatttc ttcaaaccac tcgatcaatc gcggcgtcgc 2343181 gttcggcctg tcccattcaa caagcgtatt atccaggtca gtaataattc cttttacatt 2343241 tcgttccttt aatttctcag gtgtaatatg aaaaatattt tttacaaact cgtcaggtaa 2343301 aaaaaacttt tttaacaaaa cccgcaccct tccctttttc tttctttcaa aatgattgtc 2343361 gaaaaaaatc gaacttgcgc ctaaagaaaa actgagcaaa aaaatttcga caaaaattgg 2343421 gtttcttcac caggtgtgga taaatttaca cacactatcc actcttatta catcactctt 2343481 tagacaaatt ataaacacga tactcacaag ttatccactt tttggtgtgg ataacagaac 2343541 gattgttctt atatgcattt catggtagat taaagataac ttcaacctca gatgaatgca 2343601 acttatcatt gtatgcgtta aaatcatgaa tgattccaac ttttaaggag gtgcctctcc 2343661 cattaattgg gttcctagca tgagaaaact gtctgatgaa ttactaatag aatcttattt 2343721 caaagccacc gaaatgaatt taaaccgtga ctttattgag ttaattgaaa acgaaataaa 2343781 aagaagatcg ctcggacata ttatttccgt atcttcttaa taggaatttg tctatttttt 2343841 ccgggcgtat ttcctttttt tactcagatg actgatatta tatcactttg gctgcgcgct 2343901 ttactactat tttcagcaaa aaacacccct aaaaagaggt gttttaaagg gccggttatt 2343961 atgctaacca gtatatgccg cccacaacaa ggagaacaac aactaaaaca acaataaaag 2344021 cgtatccata tgctctgcct gcgccataca tgtgaagcgc ctccttaata aggttttata 2344081 acagcctatg taggagaaat aaatcggact aggcggttgt ccggctcaac gctgcaggat 2344141 ctgcccatct tgtattcctt catatacgat ccttgcccct ttaggtgtca tatgatttcc 2344201 agaaggatct ataagaccag attggataag cgcttcatca gttgcttttc cgccgtctgc 2344261 ttctataaaa tgcttccagt tatctacaag agggacatcc aggcgcttcg acacatctct 2344321 tgtaatatcg ttatatgagt tgtgccattt ccttgctccg ccttttggtt caaaagcagc 2344381 tgcttgatat ctggaatagt aaaacaaatg atgcttccca ttaccttcta taattgggat 2344441 acacgtcatt aagattggct tgatcccgtg ttttctgctt tcttcaataa aataaaccag 2344501 attttctcta aaacgctgct tcgacactct cggtttcccc tcagtcagta tggcagcgtc 2344561 attggttccg aacataataa acaaatactt cggtttttga tccagcacat ctgtctgaaa 2344621 tcggagacgg gcatcctctg tcgtctgtcc gccgattccc gcattgagta tatcaaggtt 2344681 accgcgctca gctgttttta atatattgac ccactgctgt gcttttggat aatcgcgata 2344741 atcccaatta gagccacgcg tattactgtc accaaatgct acaacgtctt cgtatcccct 2344801 tccctcgcat cctgctgtaa cgaacagcag aaggaaaagg atgataaaat gtttcatctt 2344861 tacaccccca aaagcctcac tttaatgtta tacctctgtt tctcttcgtt caatgaagag 2344921 tttttcgcta tcactgtttt ttcctatagt taacgtgtcc ccctcagtga atatcattct 2344981 gctttcattg cggcgcagct gatgattttt taaaattccc ttctttccaa tctgaaaaac 2345041 acacaaacca aagaaaagaa aataacctga atccgcactg gaaacaggtt atccgttaaa 2345101 tcctgcattt actttaactt cgatttaagc ttggcctttg tttttggccc ataaatcccg 2345161 tctgcagtta atccgttcat gagttgaaaa cgcttgacgg cattcgctgt tttcggtccg 2345221 taaactccat ctatgccatt gtttttggct cccttatcag ggtaaaagtg aagtacagct 2345281 aaagcctttt gcagctggag aatgtttgtg ccctttcgat aaggcgaagt gagctttata 2345341 accccagacg gcagaggata tgatggtgaa gtttcttttg gaggtgtatc cgaggaagaa 2345401 attccgttta gaaaagagtt ccagtggtcc aagagtttcc gcggacattc tttcccggac 2345461 cactttttgt ggggaacaac acgatttaac ggaatattgt tttccttcat cagctttctg 2345521 atcagccact gggcatttga tgttgctttt tcaaaatcgc cgtcagcatt ttcacagatt 2345581 tcaatcccga tcgatttgcg gtttcctgtc ccgtttgtac cgtctcccgc atgccagccg 2345641 ttttcatcta tcgggagatg ctgataaatg actgaatcgt caactgtaaa atgccagctt 2345701 tcggatgtgt tcgggttttt cacaaacttg gcgtgcattt tcgcatcagc gcctttggct 2345761 gtattcgctg tattatgcac cgtaatataa gcaggcgcca tcgcatagcc aggacgatta 2345821 tcatttgata ccggtataaa atcctttttt atggttacca tttctatccc tccctattaa 2345881 taagaatgca gaaaacagag agatggacag ccttttttat gaggtaaaaa agaattgtgt 2345941 tcttaacctg gttttcagtt gaacagctga aatggcacca gttatactaa tttagatgac 2346001 ggaggttttg actcctgaca tcacctaagt tgggagtgac catagacatg ttaaaaaaag 2346061 taataggtat acttgtgatt atcgctatca tttcagttgg tttttttcag aaagaagctt 2346121 ggcttgatgc aatcaaagca ggagggatgt tttccgtttt atttagtatg ctgctgattg 2346181 ctgccgatgt ttttttccca atagtgccgt ttgctttgat tgctgcttta aatggcgcag 2346241 tgttcgggac tgcaaatgga atttggatta cactgaccgg ctcaatgctt ggtacaatat 2346301 tgctgttttt tctcgccagg tacagtttta gagattgggc cagaaaaaaa gttcaggcct 2346361 atcctgccat acaaagctac gaggcttcct tcaacaaaaa cgcttttacc gctgttttat 2346421 taggaaggct gatacctgtc ataccttcac ttgtaatgaa cgtgatctgc gggctgagcc 2346481 aggttcgctg gcatgttttt ttctttgcgt ctttaatagg gaaaatcccc aatattgttg 2346541 ttgtcactat tgcaggtgcc aatttcacca gcaataaatt attgtctatc agcatttacg 2346601 gtacatatat tctgatcatc atgctggtca tttataaaaa gttccctcat cttctgaagg 2346661 tgccaaaaaa ataaggaggc ttgttggccc ccttactttt tttctgtcgc atggcctcca 2346721 aattcatttc gaagcgcagc aaccaccttt cctgtaaacg tatcgtctgt taaagaacgg 2346781 tatctcatca ttagtgacat ggcgatgacc ggcgttgccg tctgcagatc aagcgcggtt 2346841 tccaccgtcc attttccttc acctgaggaa tgcataatgc ccttgatctg atccagtttc 2346901 gcatccttag cgaaagctcg ctcagtcagt cccataagcc aagaacgaat gacagaacca 2346961 tgattccaca ctctggcaac cttctcgtag tcaaaatcaa attggctgtt ttcaagcact 2347021 tcgaatcctt caccaatcgc ggccatcatt ccatactcaa ttccattatg gatcattttt 2347081 aaaaaatgtc cgcttcccgc ttcaccagcg tatagataac cattttcgac ggcagtatca 2347141 cgaaaaagcg gttccacaat ctcccatgct tcatgatcgc cccccaccat aaaacaggct 2347201 ccatgccgtg cgccttccat tccgcccgac gttccggcat cgagataatg gatacccgct 2347261 tctttcattt gattgtagcg gcgaattgat tctttataat gagagtttcc agcttcgata 2347321 atcatatcgc ctttacttaa taaaggtgat acatcacgca aaacagcatc gacaatgcca 2347381 tgcggtacca taacccatag gatgcgcggc gggtgtaata aagaaatgaa ctctttaaga 2347441 tttgttgtcc cctcagcccc gtatgctttc agttcatcaa cagccgcttg atttacatca 2347501 tatccaacca cttgatgatt gcggtcaatg aattgctttc ctatgtttat gcccattttc 2347561 cctaagccga ttaatccgat tttcatatct gttcctcctg attgtctaaa aagcctttac 2347621 tctttatgtt ccctatggat tgtattgtga tacgcagaaa acaaatgggg cttacatcgt 2347681 ctgcgcatgt aaattttatt tttcatgacc gacggcgcct gccagttcta ttactgaatc 2347741 tctttatatc cataattatc gctttatcct tgatttacca tcagtttaag ttaaaatatg 2347801 ggaaggaatt cgattttttc agtaaaaaga aggtgacatg ttgcagaatc aatctcatac 2347861 tcttattgga gttacgaaaa ccgctgtatt ctttttatac gctgcacttg caatcatcgg 2347921 ttttgcaatc gggtatttta ttccgcagat tgcgaaatgg gcattatccc tcccctggat 2347981 ccctcttgaa ggaccacttc ggctcattac ctcttttcag ggatctacag cttcatttat 2348041 cactgctctt ctcggtatgt gtgcggggat ttggttcgct cattctgtta ttgcaatgct 2348101 gctgtctgtc aaaattacag atcacacagt ggaattcatc aaaggaaaaa aagtgcaaac 2348161 aattcattcc gatgacatcg ctcttgtatt tatggatcac aaacggcttg tcctcctggg 2348221 aacagccgga tatgaattgg tacgggaaga aattgatgaa aaaccagtaa acgttgagaa 2348281 ggcctttaga cagcatcatt acgaatgggc aacagatggt gatccgttta aagatcaatt 2348341 tcgccgatgg attcctgatg caccagacct atcgcaaggc gcccatgcct tattaaaagc 2348401 tcgtcacaaa gcactgcagg acgaagaaaa agacgatatt gaagaattcc gtctcgaact 2348461 ggcacagctg ggcatcgttg tacgggacga aggcacacgc caatattggc gaaaagcaga 2348521 aacctatccc ccgaaaattc agctcggcga aggattgtaa caacagaggc tcaagaaaga 2348581 gcctcttctt tactactgca caataaacag cactctggta ccgtcaggat agctgctcat 2348641 ttgattccct acccacgagc cggcgccgcg attatcagaa ggcgtcacat atcggacatc 2348701 agcccctgca ccgccttcct cgcagaccgc catcggccac tcatcccggt catagcccgg 2348761 cttggtcggg attcccttta aagattcctc ccgccttttg tctgctccat ctctgtcaat 2348821 ggtacaaata tctggatgtc cctctgcaat cgcatcccta atatgactgc cggtttccgg 2348881 ataacgagac agcggaaaat ataacacttt gtcatacgaa gatgcgcctt ggatctgttg 2348941 cggaaccatt aaacaaagaa gaactgctgc agcaagaaac aggcctgcca tccatttttt 2349001 catccccatc cccccatacc tttgttcatt tcaatgtatg ggcgcttgat gaagaatatt 2349061 tttaacattt gaagttagta tgctgcttac caaagccgga ctcccccgcg agaaatttcc 2349121 cggtacagac acagacagcc tcccggtcac atacatttac atataggctt ttgcctacat 2349181 acttttgtgg aggtgacgat ggtgacaggt gttttcgcag cgctcggctt tgttgttaaa 2349241 gagcttgtct ttttagtatc ttacgtgaaa aacaatgcct ttccacaacc gctctcaagc 2349301 agcgaagaaa aaaaatactt agagctcatg gctaaagggg atgaacatgc cagaaacatg 2349361 ctgattgagc ataatcttcg cttggtcgcc catattgtga aaaagttcga aaatacaggt 2349421 gaggatgcag aggacttaat ctccatcgga acgatcgggc ttattaaagg aattgaaagc 2349481 tattccgctg gaaaagggac aaagctggcg acgtatgcag cgaggtgtat tgaaaatgag 2349541 attgtaatta caaaaggggg gtgcatacac ccctctttaa tacgtttcaa tatatatggt 2349601 gtcagaatcc acaatggtaa cttctttcac gataaagtta acaattgttt ttttatcttc 2349661 aagagttaag ttatctgcac cgattgattg aaaatagtcg atggctcttt ttagagcatt 2349721 ttcacttgag ctcgtatcat ctaggacttt catttttgac tggatttcgt tacacttttc 2349781 agtaagctga ttttgctttt tttgcagttc aataatttgt gctttgattt catctatgtc 2349841 taaatcatcg tcatcgctta ggctgattag cgttaaaaga cgcttgcggc ctttttttgt 2349901 tttctctatc tctttttcaa taagttctaa ttcatcagac aggtgatttg attgttcagc 2349961 ctctttaaaa gaaacatact tttgaggatt tgtgatgaat ttaaaaattt caccccatac 2350021 atgccggttc aatttattct cagacatttc ttttccgcag ccgcggtcct ttgcgccaga 2350081 ataatttttc cggcaagtat atacatagta gtctttacca tgtgattttc ttttcttccc 2350141 tgtcatggta tttccgcatt ttccgcatct aaccaaaccc gataacaagt aattgtgagg 2350201 gctgatactc aagtgttttc ttttactttg acctaagagt tcttgagcat aatcccattg 2350261 ttcagctgga acaattgctg gaattgtcac agtgatttgt tcttcttcag gccttatttt 2350321 aattatagat ttgttccctg cctgctttga aacataggaa ccctctgtat catatttata 2350381 ctgtctatgt tcacccttat aggaagagtt cattaatatt tgccgaacaa cctgcctgtg 2350441 ccatactttg gcgccttttt ttgttttaac ccccatctga gttaaatgta gagcaatacc 2350501 atttactctg ccgaaaaaag ggcttttatg atcggtgaaa tagttaaaaa tcatccgaat 2350561 gatttttgct tcctcttcta atatctcaag agttcttttc tctttaacaa atttatagcc 2350621 atatagttta gaatctttaa tgatcatgcc ttttttcatt ttttgaagtc ggccgcttga 2350681 tgtccgttct ttgattttgg ctttttcaaa ttctgagatt gccccgcgca ttgcgaaaaa 2350741 caattgacct tctggagaat tggcgtattc accatttaca aaaatcaaag gtatgtttcg 2350801 ctttcgcaat tcgtcatcaa tgattagctg attcattaat ttccgagaaa gacggtcagg 2350861 atcgtaacaa atgacttgac ttataagtcc cttgcttgca tcctccctca agcgattcaa 2350921 agccggacgt tctaaaagct ctcctgaaaa tccttcatct gcatacttca gcacatcttt 2350981 agtccctgct ttctttatac aggcctcgat ttggctgtcg atgctcgatc ccttgatcgc 2351041 ttgttcctcg gtcgataccc ttacatatat tgctatcacc ctgaatctcc ttcctataaa 2351101 gttttattaa ataatgatag caatcgttaa tgcatttgtc agcttgcggt ccctcgatga 2351161 ttatcacttt cataaaatgc atcacccctt gggtaatgct atgtaacagc tgtttgtcca 2351221 aatgaggaga ttttaaatta aactatagtg ttattaaacg tttcaatgaa tatgcaaaaa 2351281 atttaaaaaa agttgttgtg acttttctac actcctttag gtcctcaata gaaaagattt 2351341 tattttctat gcctcaacat tcgcttatta tagttttcaa tgatttatta ttatttgaga 2351401 gtacaatgga gtagtgtttt tcattgttag atagttaatg acatttcact ggtgtcaagt 2351461 tcgtatagct agacattaat aaaaaaagga cacatataaa tatgcatcct ttaacaaaag 2351521 agtttattta tttccctgtt tcagcaaatt ccttcaacct attccctatt tcatcacgaa 2351581 ctctttggaa aaacgcccat ttttcttctt ctgtcccttg tgctcttgcc ggatcatcaa 2351641 aaccccaatg ctcacgtttt acatgtggag gcgtcatcgg gcatttatca gcagcatctc 2351701 cacaaagcgt aacaactaaa tcagcattgt tcagaatatc agaatcgatt atatctgacg 2351761 tttgattaga gatatctata ccaacttcct tcatcgcttt aacagcattc ggatttaatc 2351821 catgtgcttc tatccccgcg ctatacactt tccactcatc acctaaatat tgtttagccc 2351881 atccttcagc catttggctc cggcaagagt tccctgtaca taaaaagtaa atgattttat 2351941 tctccatata ttccacctct acatcgagtg acttccaaag tattttcgtt gaaaccataa 2352001 agcaacctta acaagtgcta tcatgactgg cacttctaca agcggaccaa ttacggcggc 2352061 aaatgctgca cccgaatgaa ttcgatatca agcttcgcac ttaaacacag cggaatttat 2352121 aatatatgct tggacagccg taaaagccga actgaacaat ggtatgattt tgctcatgaa 2352181 ttttgccata tatatagaca tgaaggcgat aaaaaaacaa tgcctgcaac ttggactgat 2352241 tatttggatt ggcagtccaa ttattttaca tatcactttt gcattccaac ttgcatgttg 2352301 cgtaatatca accttccgta catacaatca catgcaattg aaaatgtagc ttggttattt 2352361 aaggtatccc cttcattcgc taagaaacgt ttaagcattt attacaggaa actgactcaa 2352421 catttattta gtcaaactgt tacgggaaat ttatgccccc cctttttgta atgaataatg 2352481 aaatcctcat gcatttgcgc gcattgaaaa aaacaaaaaa agacgtctcc cttcacgatc 2352541 cgatcgggca ggataaggaa gggaatgaaa taagcctgat tgacgttttg aaatcagaaa 2352601 acgaagacgt gatagatacg atccagctca atatggagct tgaaaaagtg aaacaataca 2352661 ttgacatttt agatgaccgt gagaaggaag tgattgtcgg gcggtttgga cttgatttga 2352721 agaaggaaaa aacgcagcga gagattgcca aagaactcgg tatctcacgc agctatgtat 2352781 cgcggattga aaagcgggcg ctgatgaaga tgtttcatga gttttatcgg gcagagaagg 2352841 aaaagcggaa gaaggcgaag gggaaataat gcagaagaag ccggatctca tactccggct 2352901 ttctctattt gaaagagtta tgaaaatcat ttttttcatc gctgataagc tctccgagaa 2352961 agacaggcag gatcgtaaca aataacttga cttataatcc tcccgcaggc attcaaagcc 2353021 ggacgttcta aaagctctcc tgagaaaatc cttagatcgg tatacttcag tacatcttta 2353081 gtccctgctt tctttataca ggcctcgatc tggctgtcga tgctcgatcc cttgatcgct 2353141 tgttccacga tatattgcta tcaccctgga tctcctgcct ataaagtttt attaaataat 2353201 gatagcaatc gttcatgcat ttgtcagttt gcagtccctc gatgattatt accttcataa 2353261 aatacatcac cccttgggta atgctgcgta atacctgttt gtcctaatga ggtgattttc 2353321 aatgagtatg aaaacaaata aaaaaaccga tggtttgtac catcgatctg ttttctatat 2353381 cactaggccc tcaatatagt aaatctagct cattggttat gaaagcttat tttcattaca 2353441 cactatatat tcatttgtta tcatttctat acgtttatat caattatggt aaaaaatggt 2353501 tacaaaaacc caataaacgt ccaacctaac tttttcatct tatttattaa gaattttaac 2353561 ctcttccttg tgaaataaag aagcgatttt catctccaaa cagttaatgc tatttcatcg 2353621 ggacatgtct gttaaagtag ccaataaata cattcggata tccacttaca accacgattc 2353681 aatttgatcc actacagatt tctgagctga cattaaacag atagagttat aaaaatctgt 2353741 accagttccc tttcacaatt aggacatttc ggcggcgttt cggcataatg cgaactaatt 2353801 tattaatgtt caacaacaga atttcgtcta ttggcaataa agaatccaca aatcattgca 2353861 agaatggcca tcgcccacca gaacgttgag atcgcctgat catgatcgat gataatcaaa 2353921 cgaatgacag ctgtgatgcc aatataaatg aagtagcgaa gcggaaaatg aaagtctgat 2353981 ttgaagtatt tgataatcaa agcaatgaac tcaaagtaca tgaagaatat aagcagttct 2354041 ccaagcatct cataatagct gtccactttg ttgaacagtg acttgtatac gaatagcaca 2354101 atgtaccaag tctcgctgat cagaagtgcg cttaaggcta acgccagaaa gaacagacag 2354161 acgttgagaa gcgcttgtaa caggtaaggc acctttttga atttgttaga aaatctcatc 2354221 atgttgtctc ctatttcaat atattcgtgg tttttattct cagcctacat cttggtgttc 2354281 caaaatcgta gcacaatgta gtacttagaa ttcttttgta tactgtgaaa ctgtccctgc 2354341 atgcgggaca tcattcgcgc aatgcttctt tcaccgagtc cgttgctttc cggtgttata 2354401 tctgcaagtt taatcgtatt gctaacatgg atctcaaata tctcttgatc cgatacaaac 2354461 gtgatactga ttttttcttc cggatctgcg tatttcaata agtttgacat cacattatca 2354521 aatacacgac caagctcctc caaattcacg ttaatatagg tttccggcag ctcgcctgaa 2354581 atatggaccc gaaaatgctc ctgatgaagg atagcaatct gatctgatat tagatcgtag 2354641 atcacttctt tcactgcaac ggtctccaga tcggcctcat attccttgtt cagcaggaaa 2354701 tacgcaaaca gattgtcaga caagcttttt aattgcagtg ctttaccata agcattggct 2354761 acataccgat ctttgctggc acccgcttcg cctccctctt ttttggcaaa ctccagattc 2354821 atgatcagcg acgtcagcgg tgtgcgcata tcgtgcgaca tttcggtaac caggctgcgg 2354881 ctctcagctt gcaattcctc gatagcttta agtttatcca ggaaagcttt ccgcagatcc 2354941 tcaatgctct ttgcaatcat cgctaattca tcatgccctt ttatcgtcat ctcgtagtcc 2355001 agttcgcccc cttcaagaat atgaatctct tgatgaatcg ttttaaggta gcgaagactt 2355061 tggcgaattc cgaagagaac aatgattaaa aagatgaggg ttgccccgag caaatccaat 2355121 gcaaaggcca gatcataata tcgggaagag tagaaaccgt cgataatgac tcgtccttca 2355181 ccatcgctaa acttgacagg atgtgaatga ttttgagcgt actgagtcag cttttccttt 2355241 ccataatccg attcggaata aatagaatca tattgcagct cctgatcctt gaatatggtg 2355301 aggttaatgt aattttcttt tttgacccac tcgccaaacg cttttctatc tgatgtagac 2355361 aactcatttt ctgaaacgta cttgctgaat ttttgaatgt atcttgctga ctcctcgtga 2355421 taatactctt ccgaactcag atatccctcg atcagatcat ctgtgatctt ttgcaacgtc 2355481 agaaagatca caccactcac aatcgcagca accattatca gcaaagccag ttttttggtt 2355541 agcgtaaatt taagatgcgc caaatcgata tcctcttccc cattcagttt ttatataaac 2355601 cggacgtgcc ggatcatcct caattttgga gcgcagcttc cgtatatgca ccatcaccgt 2355661 attgttggaa cagtaaaagt aaggctgtcc ccacacactc tcatatatat tttgggcaga 2355721 aaatattttg ttgcgtttgt tcatcagaag tttcaggata cgatactcca gatctgacaa 2355781 cttgatttgc ttctcctctt tccacacctc attaaattct tcgctcactc ttagtttgcc 2355841 cccgataaga aatgtttctt cctgttcctt cttttcctga tagatagtat atctgcgtaa 2355901 ttgagcaatc actctagcgt gaagttcctc ttccgagaat ggtttagtca tataatcatc 2355961 gccgccggcg agtaatccct cagttttatc gagtgtactc gatctggccg tcagaaacag 2356021 aatcgggacg ttagaggatt tcctgatgtg ctgacatgtt tcaattcccg aaatgcctgg 2356081 catcataata tccaaaataa ccaaatcaag cgagtcattc acaagttgca atgctcgctt 2356141 tccatccttg gctcttagca cctcgtaacc tgcacgtgta agggattcct ccaaaagatc 2356201 accaatatcc tcatcatcct ctacgactaa tattcgatag gccatgtctc tctcacctca 2356261 tgattcttgt tgttatttct cgtgtgtcct tactatatat cgttcatagt aataagtacg 2356321 ttataagata ctacgtaaat cttaacaatt tatgaaagct gatgctcgcc acaaatttgt 2356381 cacattttct aaaaaaaatg atgactcttc ataaattgtt aagattcggt ctttatattt 2356441 atccattgta aggctcaagt ttttcagatc cgcactacac attgccgtga taaatgggaa 2356501 aggagtattg atatgattgt acaaaaagaa ggacgcgggc aaccggtgag tctgcgggaa 2356561 cgggttcatt ttctggacat cgtacgagga tttgccttgc ttggcattat tattgtcaat 2356621 tattttctga tcgtagattc agtaaaggga ttcgaaatgg cctccgatga cgtactgcat 2356681 aagctggttt cctggtttgc cgaagggaaa ttcgttacgt tattctcctt cctgttcgga 2356741 gtcgggttta tgatctttat ggatcgagcc gcgcagaagg tagagagtcc caacaagctg 2356801 tttgcccgca ggttatctat cctgttggga tttggcattt tgcacatcac atttgtttgg 2356861 gtcggtgaca tattggcctt ttacgccgta agtggcttcc tgttactcgc cttctataaa 2356921 cgcacggcca aaacggtgct tagatggatt atcgcactta tcgtgtttca attcctgact 2356981 cctgttttca caatgttgta caatgtcatc aatactgcag ggtcaaaaaa cccgaatttt 2357041 tcagagttta ctttgtttag ccacagcagc cttacctaca tggaatccat cagcactcgg 2357101 tggacagata tggtcacgat ggctgccggc tctttctcta tgatctattc catgtttctc 2357161 atgtttctgc tgggcgtgta ctttgttaag atggaatttt tcaaagacat ggaagcgaaa 2357221 aagcctatat ggaagcgtat ctggatcatt agcacaatcg cttttctaat aacacaaagc 2357281 agtatattac tagacatgtt taatctttct gagaatatgc tgtggaagga catttcctct 2357341 gtcttgggtc aaaatggcgg cttaaccgga agtatgtttt atatgagcac ttttgcaatg 2357401 ctgtttctat accttcctca gctgcgaggc cctatgatga tattcaccaa agtcggacgg 2357461 atgtcattga cctgttatct gcttcactct atcattggaa cagttctgtt cctcaggtac 2357521 ggattcgggc ttgcggatca tattcaatcc gccggcacgt tcatgttcag tctggccgtg 2357581 tacttcgttc ttatgagctt tagtacattg tggttgaaac ggtttaggta cggtccgatg 2357641 gaattagtat ggcgcaagct gacgtacggc aaagtaaacg ggagtcccaa agcaactccg 2357701 ctgcattcgg aaaaatctat tcagaaataa cccccttgca cagattgcat gacttcaaat 2357761 tagtgttgtt gaatgaagcg ggcattaaac ggacagattt gatatatgga ctagttattt 2357821 ttatatcatt taggcttctt tgggctaata aatccaccag agtttactca atgtgcattg 2357881 ctcatgatcg aatctaaatt gaatctttta cgcatgttca tagtcaaagg cgcctcattc 2357941 gactattttt gtaacttttc gcaggaaaaa ttcgagaatg atgacaaatc ccgcatacga 2358001 cacttaatac ggtagtgaac aatagtaaat tagggttaca tgcagcttgt tttccaatga 2358061 aacaaagaaa aagaatcata caaaaagaca ggagaaagct tttgaagtat tttaacgcca 2358121 aatttaccgc ggaagaaaga gcgatggaat cacttttttg tgaaaaggcc tcgcagagca 2358181 gctcgaatgt tttactgaac gactgaactc tatattttag caactgaggg agtgaacaat 2358241 catgaaaact aaaaatgaac caaaagttat tctggaacta gcaaaggaat ctgatctgcc 2358301 agaattccaa aaaaaattac aagaagcctt tgcgatcgcc gtgattgaaa cgttcggtga 2358361 ttgcgaagat gggccgattc catcggacaa tgatgttcag gagtctttca atgctcccgg 2358421 agcagtggta tatcatattc ttcaggatgg taagaatgtc ggtggtgcag tagtacgtat 2358481 caacagccaa acaaatcata attcgctaga tttattctat gtatctccag aatatcacag 2358541 ccaagggatt ggtctttctg cttggaaagc cattgaagca cagtatccgg atactgtgct 2358601 ttgggaaacc gtgacacctt atttcgaaaa gcgaaatatc aacttctatg tgaataagtg 2358661 tggatttcat atcgtagagt tctacaatga acatcactct aatccgcata tgcatcgcaa 2358721 tggacgtgaa gatgacaagc ccctactgaa tgatgatgac tttttcagat ttgtaaagat 2358781 tatgaaaaaa aaggactaaa caattgaaca cggcgagatg ccgcagagag ttgctggtaa 2358841 cttttttata tttcattatc agaggaaggt aataatgatg tttaaaaggt gttttgatcc 2358901 ctgtctcata aacaggggtc aaaacacctt tgaatcatcg gtttcttttc tgacatatac 2358961 cacgcccact agtccctcaa catagtaaaa acatatcatg agttacaaaa gcttttattc 2359021 aaagcatatg tttattttat ttatacttat tttcatcatt tttcagaatt ctggacacaa 2359081 atcgggtacc tattagaggc caaggaactc tacatttcat taagaaatac gtactcattg 2359141 ccctgcttta attaatttta agccctcgca ctatgccccc ccctgaatta agtatttgat 2359201 gtaactttga aattaagttt atgaaaatct gtcacaaacc cttatttcat aacacatcat 2359261 ttgtttcagc ttccctcgcg aataccggat taatgctcgg ctttaagata gtcaaccaat 2359321 ctctccgcac tgttcttaac atcttctttt gaaagatgaa gtgtcccata ttgtgtaaac 2359381 gcaggaagaa aacgcattcc tatatagtta gcagtgactt gaaacggtct gataagctcg 2359441 ctgatcgtga tattatattc tccgcctgct tgataatcag attcctgtgc gcctaaggag 2359501 atagctaaga gtagttcttt tccatgcaat ttagttcctc cagttccata agcccagcca 2359561 tgtgttaaca catcatcttc ccattgtttg agtaacgcgg gactgctgta ccaatacatt 2359621 gggaactgaa aaacgatacg ctcatgatct aacaggagct gctgctcttt ttctacatca 2359681 atgataaaat tagggtattc accgtacagg tcatgaaccg taatgtcttt ctcttgcttt 2359741 aaacgattca tccaggtttt gttgacaaca gacgtttcca aattaggatg tataacgata 2359801 actaatgttt tcattagact gattatcctt tctttgccaa ttagttatta ttttttacga 2359861 taatgaattg attctaattt taaaatagca actttattta cacctatttt atcctttttc 2359921 atgaattcag ggcaactaat tgggcaccaa aatcaatgat gacttaagac attgttttgt 2359981 agaaatccga tatacagaat aatccattat ttagaaaatt tctacctttt ccctcaatcc 2360041 ttaccaattt aaactcatta aggagatact ttatcaccaa ctttaaataa taatggaata 2360101 agtgctaata aaataattcc tacaaccaac gtagatatta ttaactcctt ccatacaatc 2360161 aaattcttta aaaacatttg ataaataact aatgagttta ctggaatgtt aagcaataag 2360221 cccgtaagaa gtccaggtgc atactttttc attacaacag ttgcgataag atgtggaaaa 2360281 atagcgttga taaccataga acctagaaag ccaatgaaaa tccattttgc aatatctgat 2360341 tctggcatat ataaaaaacc aaatgcagat aaataagcca acatagttat aacaatgaca 2360401 gcaaaatgaa attcatttga agttactggc ttttgaaact ttgaagattg ttgtgaccac 2360461 tcaggtaacc aaatagcttc ctcaatatta tgaagtgtaa tagcaaaaca aaaaaatgct 2360521 acgaaataaa ccacctatca tttcctcctc ggtgccacaa ccaatatggt ttggcaacat 2360581 tatattacat ttgaggctga ttggatatgg tgttaaaaga gagaagaatc tgccttagta 2360641 gttgcttctt aattatatgt gcaataacgt gttgttacgt ggcatgtcat attcaaatat 2360701 aataactcta aagcaaacaa agatacctat atagtttggc atcctctttt ttagttcgag 2360761 tccctctatt tattttgggc acaaaataga cataatttat attgactcat tatacccatc 2360821 acataccata ccccttaaac caatcaggat taaaatgttt taaaaaaggt gatcaaagat 2360881 taagttatgg tctcttttat tttatgtatg ctgtcttaat gcaaaacaac actggacacc 2360941 actaagtcaa atgcatttca tggtactata gtcaagactt gtccaagtca ccattatcaa 2361001 aatgaatttc atcaaacact tgaaacattt attgaacgcg gccaagtgtc ataacattaa 2361061 taagaaacca acgagtgatg aatcttttaa tctttcattt tacccgctgg ctcatatcaa 2361121 aggagctcta accaaatttt aatagctgtc gcacctatta attgcgctaa aacccattgc 2361181 aggaattttg tatttacttt ttgcccaact gatgcgccaa taggagaagc tattaaacta 2361241 gtaatcataa gaaccagagc tggtacaaaa agaacctggc ccgtgattac ttttccaact 2361301 gttgcgccaa tggatgaaag aaatgtaatc gcaagagatg aagcgactgt gactctaaca 2361361 ggaatattta aaatcgataa cataatgggg actaggataa aggcgccgcc agctcctaaa 2361421 atacctgata cgccaccaat gataaacgct aaggaagaag ccaaccattt attaaatatc 2361481 acttccttat cttcgctatg ttcttgtcct ttctgtcctt ttttaggtat aaacattaaa 2361541 ataactgcta taatagccag aattccgtat ataaagttaa ttcctttttc agatatataa 2361601 tgagaaaagt aactccccaa tacactccct aaaaggatgc tgcttcccat gtaaataatt 2361661 aatgttttat ttataagacc actcttacga taagcccaaa caccgccgag tgtcgcaaaa 2361721 aaaacttgaa tagcccctat ccctgaaact tcatgggcag ttaatgacat cactcccact 2361781 aaagaaggaa tgtacaatag cattggataa ttaataactg ctccgccaat accaatcatt 2361841 ccggaaataa aggcaccaat aaaccctata atgaaaagag ttgtgataaa ggcaatatcc 2361901 attttatttg cctcctttca taggaaaagg gtatctttct attcgatacc ctttcacatt 2361961 cattagcctt tttgaatcca aaatttcaat atatcgccct cgtccgtttg ctctaaaagg 2362021 tcatgtccgc ctgatttaga ccaggctgta agatcatttt tggctccctt atctgttgca 2362081 tgcacttcta atatttgacc tgattccagt tcattcatcg ctttttttgt tctgacaatt 2362141 ggcattgggc atgccaagcc ttttgcgtct aatactttat ctgatttcat gttcttctct 2362201 cctcttttta gcagaaactt gtgttaccgt attgcacagc ggtttgggcc aatctccatt 2362261 tcacgctgtt tttcttcatc tgggctgatt ttccccatgt ttgtttctcg aatctcttgg 2362321 tatgcatttg gttgcggagg caaatgatct gttactaggt gtctaaattc tgtttcatcc 2362381 gcaatgttca aaccatggtt ctcgctaaat aatgtactta gttgtttacc aacacttcca 2362441 ttctcattta gctcgtcaat gatcataaag tgtgccggta atacaattaa atcctttgat 2362501 aacgctttgt aacggctata aagcgttttt cttaaatctc ctacccaatc ttctgccata 2362561 ccggctaagt ctggtctgcc gattgaatca ataaacaaga tatcacctga aagaagatac 2362621 tggtcatcga caatgaaaga agtggagcca atcgtgtgcc ccggagaata aatcggttga 2362681 attttaatcg ttgtatttcc aataataatg tcatttcctt cttccaacgg ctgataatcg 2362741 aattccactt cttcagcatc tttaggcggt aaccagtagg ttgcttttgt tttttcagca 2362801 atgactctgc cgcctgaaat atggtccgcg tgaagatgtg tatcaaatac gtgagtaatc 2362861 gttgcaccct tccccttcgc aaaatctata aagaaattca ccatacgtgt cgcatcaata 2362921 attgctgctt caccattgga aatgaccatg tatgacaagc agcctttacc gattcgaaca 2362981 aactgataca tctcaccgcc atcttttaaa tccccgactt ttaccggctc taaatgttcg 2363041 ctccatgctt tcattccacc cttaaggtag gatacagaat gacctgcttc agaaagcatt 2363101 tcggatacca tgacggatga accttctttt gcgcaaacga ccagcacttc tttatcagaa 2363161 ggaattttct ccaagatatc ttctacgcca tctaaaagat caaaataagg aacattcaaa 2363221 tggtcaaagt catgcccttc tatcttccaa tcactaaaat cattttcatt acgcacatcc 2363281 aaaataaata aaggttcttt gttaaagatt tttttgtcac ttcttttggg gtcattgcct 2363341 ttacggtcat gtttcaatac ctcctatatc aaatctttta gcgggactaa aacgttaagg 2363401 atacatcagc atctttcgta aaaccaaaaa aggtaacagc cccgcctact tcgattcctt 2363461 ccataaaatc atcttttgtt aaacccataa cgtccatcgt tatttgacaa ccaaatcatg 2363521 caactcccat ttcaatcagt taagaataga aggcacattt gcgttcctac aaccttctgc 2363581 gacatgctct tttccttgtc gcaatattac agactttata agcatcaaac agaccgctat 2363641 ttgccgcaat aatcgctact cttgtactca tctgttcatc atgcttttta tttattcggt 2363701 tttacctgtc caatcccgca tacccgggac aacattaata acctttttaa aaccttgttt 2363761 tttcatggtg cgggccgcca tttcactcct tcttcccgaa tggcagataa tataaatttc 2363821 atcattttcg tttaattcgt tagcgcgctt ttccacttca ccaagaggga tatgcacaac 2363881 tcctgggata tgagcttttt catattcctc tatctctcga acatctaaaa tgttaagaga 2363941 ctcgtcacta tctactttct gtttgaaagc ttctaatgaa atctcaggaa ttgaagatgc 2364001 attttctgat gaatgctctc ctccttttcg aagaaaatga cgaagtattt ctccctctgc 2364061 ttcagtaccc agatattcat ggcctgtact ttttgcccat gcttccagat ctgctgtaga 2364121 acctttatct gtcgcatgaa tttccaatac ttcaccagct tttaaatcct tcattctctt 2364181 cttcgttttt acgataggca ttggacacgc caaaccttta gcgtctagta caatagttgc 2364241 tttcatcatt ttttcctcct tttcttatat aggggtgggg gtatacaaat atacaaaaag 2364301 tttctcactg taagttaaca ccatgtattc ataccccctt ttatatttgt gatgttttta 2364361 aatccttgtt tcttcaatat ttttacttgc ctttaaactt ctcattccgc ttagcaatga 2364421 gtaaatgagt aacattagat aaataagttg acactgcctt cctcagcatc tgccaaataa 2364481 gctgctacac cagcatagtc aatatcatct aatagttctt tttcctgtaa accaagaaga 2364541 tccattgtca tcgtacaagc tacgagcttt accccctgtt cttgagccat ctcaatcaac 2364601 tgaggtaaag taagtacatt atgctttttc atcacatttt taatcatttt agggcccata 2364661 cctgcaaagt tcattttaga taaacccatc ttatcagcac cacgaggcat catctttcca 2364721 aacatttttt caagaaatcc ttttttcact ggaatcagct cttctttacg taaagcgtta 2364781 aatccccaaa aagtatggaa gatcgtcact tcatgatcgt aggcagctgc accatttgca 2364841 ataatatagg ctgccattgc tttatcataa tccccgctaa ataaaacaat tgttgtgcgt 2364901 tttgtttgtt ctgtcatgtt tattctccta actaattacc cctgcgggta tattaaagtc 2364961 aaaaaatttt ttcgaaagat ctgcttttat tcaactcttt aaataccata gggggtataa 2365021 tataacgcat ataaaaattc gtcaacctta ggttgatgaa tttttatcgg ctctttacca 2365081 ataagtcgac tgcttctttt actaaatttt gtgtgtcttc gcctttttct aaactttcac 2365141 gaacacaatg ttcaaggttt gtgctcacaa ttaaacccat cgctcgatcg atcgcattac 2365201 gggaagctgc taattgggtc acaacctctc tacaatcttt tccttgttcc atcatagtca 2365261 atacaccttt aatttgtcct tcaatccgtc gtaagcggtt tttaatcttt tgatcatact 2365321 ccatatatca atgaaatcct ttctttcatt tatttttaca tttacatgtt gccagttcat 2365381 aactgtttac atggatacct ttgcgcttta gaaaacgcac tcctaaattt aattccaccc 2365441 ggtcacgagc tattatgtgt attttatcac gtggaatctc taaataaaaa cgttttagat 2365501 acgcatatgg gatgtttaaa ataatattat ccgaaaaatt ggctacatcg ttataatgac 2365561 gaatatctaa tattgtgatg tccatagcct ctaatttatc tttatggata caagagattc 2365621 cggttatagg ataataacgt ctatacgttg caatgataat cacaaaaata agcaggaatg 2365681 caataactaa ataattgata ctatttacac caccttatta actctttgtt tattcacaaa 2365741 acaataatat acccccatag gtatatagtc aagtgtgaaa gttactttct ttgagctgat 2365801 agattcattt cgatatccgc ggattgaaaa aatacttaca ttcgataatg ccaattctgc 2365861 taaaaggaac tcgaataaag caataagccg atttaatttt aaatcggctt tatttatcaa 2365921 ttacttaaaa ttagcacaag acacgctgct tggatattaa atggggtttc attagcatgg 2365981 tactggttcc ccatgtttca tgctggatgt gactttaatt attctagaat tctccagaat 2366041 atctgtgcta atcttccgca gccactgcat ctgctttggt ttcatgaact gtaccaaatg 2366101 gatggttagg aggagcataa atggagtaaa gttttaatgg cgtatttcct gtattaatta 2366161 cgttgtgcca agtgccggca gggacaacaa tggcagaatc atcatagaca tttctttgaa 2366221 agttcaaatg atctttgctc tttcccattt tgacgatccc acgcccctgc tcaatccgta 2366281 agaactggtc aacgttagga tggatttcca aaccaatgtc ttctccaata ccaagactca 2366341 tcaaagtaac ttgaaaatgc tttcctgtcc ataaagcagt acggaacgta ttgttttgtt 2366401 ttgtggctct attgatattt acaacaaatg gttttggtcc ataatccttc aaaagaaggt 2366461 ttctatcttc atatgaagag cgcaaatcgg cacctctgtg tactttctcc atctcatttg 2366521 gaatagtcca ataaacagat cttccatcat tatacatcgg cacagtcaca taataataac 2366581 attgaggcga aaaagggtta tagtacattt tttgatcccc gcaattataa atttttgtga 2366641 tagtatccta tgcatttatt aagggagtgt gctaaatcaa gaaaactcat attaaacaca 2366701 aaaatgaatg ttcgatcacc gtttgattca tggatgaata atttatcacc gaccttgtaa 2366761 tcgttttcta gatgttgaat ttcactagcc tttgttaaca agacatcgaa tgacaccttt 2366821 atatgatgga ttatcaaagg tcgacgatcc taaatggctt ttgaacattt acatagcaca 2366881 acaacagagt atacggaatt ctgttgtttg tcccccctat cccagctctt ttagatttat 2366941 ctctttggat gcgccttgat ggccagtttt tcagcagcat agaatttatc ccctcctgaa 2367001 tcgttatagc atatttcaac gccgatagac ttgcggttcc cagtgccgtt tgtaccgtct 2367061 cctgtatgtg ggctcgcttt tagtaaacca gtttatattc tttttgggca cacaacagaa 2367121 acaattttcc atatgaaaat ctcgtaattt tacacctctt taacttgaag gaggattttt 2367181 gcatatgtat tttcataccc gtcaactacc atctcatcca gcatatattc ctcatatgca 2367241 ttttccccta tttgcattcc atttctttca atgaactcaa tgattctccg gtacgcctct 2367301 tcagtatttc cgcctatttc atatccaact gcatacaggc cttttggccg tacatgataa 2367361 tttatgttct ctgccccatc ttttactttt atataaaagt aactgtaatt gtagaagtct 2367421 ttttctaaga tttgttcccg tgcaaagatt ccgcctatcg gatatccttc atctaattca 2367481 tattgctgaa cttcatgaat gagttctgaa atggctgcca catattttcg ttctggtaag 2367541 tttaatgttt ttcggcttaa catgaatgtt tcttcattta aatattcaaa agaaattgag 2367601 gaaaaatcag tctcaagtgc ttgttctgta agcgtcactt ttgtttgtaa gatcgtttgc 2367661 aactgcttaa gctcatttat ttttttatca atctcaatag acttttcttt tagaacatgc 2367721 aggatcttgt ctggtgtttt tccttttatt agacacttta tttcttttaa tggaacccca 2367781 agctctttaa atagactgat gacttgaaaa gtctcaaatt gatgatagga ataatatcta 2367841 tacccatttt ctttttttat ttccggcgag aaaagaccaa tctcatcata atgaaataaa 2367901 gtttgttttt ttacacggca gagcttcgaa aactcccctg ttgtgaaata cttcttaaca 2367961 tcttcgctca taaaaacctc cttgactata cggtaaccat ataccttatg atttgattgt 2368021 acttgaaaaa agcttcaagc gaaaaggata ggtaaaaagg gttcaattga gtaaaagggg 2368081 aattcagatg aaaaaatcaa taaatgagca aaaaacgata ttcattatac tattaagcaa 2368141 catcttcgta gcatttcttg gtatcggttt aatcattcca gttatgcctt cttttatgaa 2368201 aatcatgcat ttatccggca gcacaatggg ttatcttgtt gcggcttttg ccatttctca 2368261 gttaattact tcaccttttg caggtaggtg ggttgaccgt ttcgggagaa aaaaaatgat 2368321 tattctcggg ttgcttatat tcagtttatc tgagttgatt ttcggattag ggacccatgt 2368381 ttcaatattt tatttctcga ggatattggg tggtgtaagt gcggctttta tcatgcccgc 2368441 ggtaacagca tatgtagctg atattacaac cctaaaggaa aggtcaaagg ctatggggta 2368501 tgtttctgct gcaattagca ccggctttat tattggacct ggtgcgggag gatttattgc 2368561 cggctttggt atccgcatgc cgtttttctt cgcctccgcc atcgcgttaa tagcagctgt 2368621 cacttccgtt tttatactaa aagagtcatt gtcgatagaa gaacgccatc aactctcatc 2368681 tcatacaaag gaatcaaatt tcattaaaga cttgaagaga tccattcatc ctgtctattt 2368741 cattgcattt attatcgtct ttgtaatggc ttttggttta tcagcttatg aaacggtatt 2368801 cagcttgttt tctgatcata aatttggctt cacaccaaaa gatattgcag ccattattac 2368861 gattagttcc attgttgcgg tagttattca agttttacta ttcgggaaat tggtcaacaa 2368921 acttggagag aaaagaatga ttcagctgtg cttaataacc ggtgcgatct tggctttcgt 2368981 gtctactgtt atgtcaggat ttttaactgt tttgcttgta acttgtttta tttttctggc 2369041 gttcgatttg ctacgtccgg ccttaaccgc tcatttatcc aatatggccg gtaaccagca 2369101 gggtttcgta gcaggcatga actccacata caccagcctg ggaaatatat ttggacctgc 2369161 tctaggcggt atactatttg atcttaacat tcattatcct ttcctttttg caggtttcgt 2369221 tatgattgtc ggccttggtc ttacaatggt ttggaaagaa aaaaagaatg atgctgcagc 2369281 tttgaattaa ttcattttct ataaagttaa gtcatttgga tgcagggaat gcccctggtt 2369341 aggcacaata agaaaaggta cttaatttga taggctacat gttgcttgac gtgaatatag 2369401 tataagctga gttttagcaa tatcaggata ccgggataag aaaaaaggag aatgtagtat 2369461 gagtataaac ataaaagcag taactgatga taatcgtgct gcaattcttg atctacatgt 2369521 cagccagaat caattatcat atattgaatc tacaaaagta tgtttagaag atgcaaaaga 2369581 atgtcactat tataaacctg tcgggcttta ctatgaagga gatctagtcg gttttgcaat 2369641 gtatggattg tttcccgagt atgatgaaga taataaaaac ggacgagtct ggcttgaccg 2369701 attttttatt gacgaacgct atcagggaaa aggattaggg aagaaaatgc ttaaagccct 2369761 cattcagcac cttgctgagt tatataaatg caagagaatt tatttaagta tatttgaaaa 2369821 taatattcat gctatacgcc tttatcaaag gtttggtttt caatttaatg gtgaactcga 2369881 ctttaatggt gagaaggtaa tggtaaaaga gctatagata tccaagcctc cttgtttgct 2369941 gagaaacgtt tgaacttcga taatgattac ctacttaaac tgcaagatca ttgtttaaaa 2370001 aagcctggat gaaaatttca tctcaggctt taagcatctt attagtcaaa atctcatgtg 2370061 ttttatccag atgttattct tttttccgga caatttctaa ataattaata tgccggccaa 2370121 ctgtttcgtg cactttaaaa atatacccat cggcttctat aacggaccca actgcagcgt 2370181 ctatttgttg agtcataaac cagccgccta ttgtatccac ttcgtcactt gctaacgtcg 2370241 ttcccaataa atcatttaca tcttcaatga gcactttcga atctaagata tagtgattat 2370301 catttacttt tctaatatta ggcacttcat ctttatcaaa ttcatctctg atttccccga 2370361 caatttcttc aagaatatct tcagcagtga ctaaacctga agtgccgcca tattcatcca 2370421 caagaatagc gatatgtgtt cgctcttttt gcatttttac caatacatca tgaattggaa 2370481 cggattcaat aacatggata acagggttga tatgattttc taacttgaaa tcctctttta 2370541 tcttctggtc tgtgtcaata taagctgaca aaaattcttt agcattgata aaaccaatga 2370601 ttgaatcttt atctccattt aggactgggt accttgtata gctctctgtc ttaatgatct 2370661 taacaatagt ttcataagaa tcctcactag aaatcgctac gatctctctt ctcggaatca 2370721 taatttcttt ggcgattctt tcatcaaatt caaaaatatt atttacatat ttcaactcat 2370781 tttgattgat ttcaccgctc ttatagcttt cagacagtaa gatgcgcagt tcttcttcag 2370841 aatgagcaag ttcatgttct gatgcaggtt tcaaaccgaa gagtcctact ataaaccggg 2370901 ctgaaccatt taaaaaccat ataaaaggga acaggatgcg gtaaaaccaa ataattggct 2370961 ttgcagtcaa aagagtgatg gtttccgctt tttggatagc gagtgtttta ggagcaagct 2371021 ctccaactac aacgtgcaaa aaagtcgcca tcacaaaagc aatcactaag atcaatacat 2371081 gtgagactgt ttcacttaca tgaaaatgag caaataaggg gtgcaaaatc acttcaaaag 2371141 tcgattctcc gacccagcca attcccaacg ctgtaaccgt gatccctaat tgacaagctg 2371201 acaaatattc gtccaaatga gtaatgacct ttttggctga tatggcacct ttttttccct 2371261 ctaatatgag ttggtcaatt tttgatgacc tgatctttac tatcgcaaat tcagtcgcaa 2371321 caaaaaatgc tgttaagaca attaaaagag taaagattat aaggttaatg gttgtcaatg 2371381 atttgcctta cctagtaagg cgtacacctc cgatgtaaat atttattgaa taaacaaaaa 2371441 acagtatata taacattata agttcaaaag aacctaaaat caactctgaa tgatgtaaat 2371501 aatcatcttt ttccgtatgg agagtggttc ccatagtctt caactaacga ttagtggcgt 2371561 tttaaggctt aaaaaagaaa gcaaaataaa aacacacctg aattttctgg tgtgtttcaa 2371621 taatacccaa ccgtcttgat ttatttaatg tctttataaa gattttcttt taaaatttga 2371681 atcaattcgg cctgttgctt tatatttttg cggccatttc tattaattgc agcaagttca 2371741 cagacaattc cagctgaaat gaaaaacaat aaaccttcaa acattttaaa tcccccactg 2371801 tctaagtgat agtcaaattt gttttttctt tttgcaatac ctgcttataa tcttccttac 2371861 gctgatatat gttatttaaa atgagtccaa taatgacaaa cagtgttcct actatatcaa 2371921 aagcagttat gttatatcct ttgatcacca tgattaacaa tgtagtaatg gggacaaagt 2371981 taataaataa aatcccatta atggatgata ggattttaat gccatagttc caactaagga 2372041 gggctatgat acctggtaaa gtaatcataa ataaaaaatc atacttaatt gctgcaatca 2372101 ctttaatact cggtaccgac acgtaacctt gcgcggtaag tatagctgtc atgattcctg 2372161 ttatagctgt gccgaataaa catgtcaaag ttgaataacg aagtgtggac cactctcgga 2372221 atatctgtcc ccccattgtg tagacaaccc accctaaaac accaatgaat ataaagagta 2372281 tcgagaatag atgatcccct aatgaaaaaa agaaacttat attacctttg gttatgacca 2372341 tcgaagcccc caaaaaggca atcaatatac tgatcattgt gtatttttta ggtttcacat 2372401 gtttatatcc ccatagaata acaattgaaa gcatcggcat gagtgcctcg gcaatggatg 2372461 ctgtcataat tccagacttc cccatcaacc tttgacctaa aaaaataaga acattgtata 2372521 tagtaaacgc catcacccca aataaaatga tccattttgc tttaccctct aaatgaaatg 2372581 atttctttcc ttctctcacc aataataaaa tcactaacat aatcgttacc acaccgtagc 2372641 gaataaatga aaaataaaac ggatcaacaa attctaatgc atgatctgca actggaaaca 2372701 tcgcgcccca agacatactt gctactaaac atgtaagggc accaatgaat aattgacctt 2372761 ttttcattga attcccctcc ttttctttaa aattacaatg agaattataa aaagaagtaa 2372821 gcatcaagta aaatgaacaa aagtgatgaa aaacatcatt gataatgata ctttaatgaa 2372881 ggggggatct tcatggaact gcgagactta caaattttca aatgcgtagc ccatcacaag 2372941 agtattaccg gtgctgcaaa agagttaaat tatgtacaat ctaatgtaac tgcgcggatt 2373001 aagcaattag agaatgagct caaaacacct cttttcaatc gccataaaaa aggggtttca 2373061 ctaagcccag agggccgaaa aatgattgaa tacgttaaca aaattttgaa agatgttgaa 2373121 gaactggagc aagtctttct agatactgaa ataccgtctg gaatattaaa aatcggtaca 2373181 gtggaaacag tgaggatact gccgaccatc atagcttcct attataaaaa gtatcctaat 2373241 gtggatttat cattgcaggc tggtctaaca gaggaactta ttaaaaaggt catgaatcac 2373301 gaattagacg gagcttttat ttcaggcccc ttgaaacatt ctattctgga acagtatgat 2373361 gtttatactg aaaaacttac tcttgtaacc agtaacaaaa cgtttaatat agaggatttt 2373421 tcaacgactc cgattcttgt ttttaaccag gggtgcgggt atcggtctag gcttgaacaa 2373481 tggctcaaag atgaaggtgt gctcccaaac agaatgatgg aatttaacat cctagagaca 2373541 atcttaaata gtgttgcact tggactcggt ataacagtgg taccggaatc tgctgttatg 2373601 catctagctg tacaaggtaa ggtttattgc cacccattgc ctgagaaaga cagctgtatc 2373661 tcaacaattt ttatacgcca taaagatgcg tacctgacaa attcaatgcg cagcctccta 2373721 aagaccattg ttgaacataa aaatatgagt atggcttaaa gtgatttttc tctttctata 2373781 ttctaacttc ttaaataaaa gagaaggctc atctccactt cgctaccctt attcacgcaa 2373841 aaaatagagc agtaaacatg tgagttactg ctctgcttcg tttattcacc gttcatttgt 2373901 tttacaatgt attcagcatc atttcctacg ccttgaagca acgctgaacc tcgcttatgc 2373961 tgccaaggca aacctataaa gtacaatcct tctacaggtg aaacacctct atgatgtatg 2374021 attcgacctt cttgatccaa aacacctttt atatttatcc aacataaggg attcctgaaa 2374081 ccagtagccc aaataatatt gtttacttct aatgtagatg aatctttaaa aatgatttca 2374141 ttttgctttg cggcaatgac tctttttttt aagatgatct ccttctgttt tattgcatgt 2374201 tttaattcat gcccaaatac tggatcacct ttcttttgaa tgaatttgcc tactattgat 2374261 gtatgacttg catgtaaaac tcctagttta tcaaaccacc aaaagatgct tctttttccg 2374321 atcattaaag ggaaataaac aagtttatta ctacaagcta aatatgtaac tctttctttg 2374381 gataattcaa cagctatttg agcaccacta ttcccaccac caactactag tacatttcca 2374441 tatgccaatt gttttgaatt cttatattgt gatgagtgta gttgattaat attatcggat 2374501 aaatcctttg atattgatgg aatattaggg gtatgaaaag gccctgtagc aatgacaaga 2374561 ttcttcgttt gatattcttc ccgatttgtt tttattaaga aataattctt tatttttagg 2374621 acacttatta cttctgtccg taattggatt ggaatttcaa attttttaac atacttcttt 2374681 agataagcaa caatttcatt ttttgaagga aatccatgtt tttctccttc aagatgcatt 2374741 ccaggcaaag agctatacat tcgagaagta aataaaacta atgagtcata ccgatctttc 2374801 cagctctccc ccacctcatg acttttatcc aaaatgataa acttttgatc ggactgctta 2374861 agataatatc ctattgagat ccctgcttga ccagccccga ttactatagt gtcgtacaca 2374921 ttatcacccc gccaatttca aattgtcagt agacagaatc tgcaaaatcc tagttgatct 2374981 cctcactata aagttagata aaaaatttaa tggtgatggt ggtcacgctg cttctccatt 2375041 ttgggctgac aaaggatcgc attgtcgtgg ttatgcgctt cggtttccat ttgaatggtt 2375101 acgtgcgtaa tgcctttatg ctcaagttca tgttcaattt tgcgtaaaat attttcactt 2375161 tctgaaatgg tcagttgatc gtcaacaact gcgtggcaag aaagagcatt caatccgctt 2375221 gtgatagacc atatgtgtaa atcatgaatg ttttgaattc cctctgtccc ttcaattgta 2375281 cgaatgatat cagagacatc gatattttct ggagttcctt ccattaagat gtgaatggaa 2375341 tctttagtca cattgtaacc gcttcttaga acaagaatag ccacaatgat actagccaat 2375401 ggatctgccc agccccatcc aaagaagatg ataagtatgg cagctaaaat ggcacctaca 2375461 gagccgagca tatcgcttat tacatgtaaa taagctcctc ttatattcag attattcttt 2375521 gtatctccgc cactcatcat aatccaagcg accaatagat tcacaactaa cccgatgata 2375581 ctaattgtaa gcatgccggt tgttgctact tttggtggat tagagaagcg ttcgattgct 2375641 tcataaatga tataaagaga aataagaatt aaggcagcac cgtttatcac agctgcaaga 2375701 atctcaaatc gtttatagcc gaatgtctta ttgtgatttg cctttttttc agctaatgta 2375761 aaagcaatca gggcaaccat taatgaaatt gaatcactca gcatatggcc tgcatcagat 2375821 aaaagcgcca ggctatttgt taaaaatcca cctatagctt ctataatcat ataacctgta 2375881 atcatgataa aagagatcaa taaaaccttt ttatttgctc cttcattatg attgtgaccc 2375941 ataaaaaact cctccttacc taaagttttt aatacatatg tatttattat ttcaaatctg 2376001 ttatgaagca ttctaacatg atacaaataa tatttatata tgagcatgtg ttcatatata 2376061 aatatatctg ctctttactg aaatgtcaaa atatttttat agaaatccac aatacctcct 2376121 taattattct tttataaaca taaaaaagcg gagcaaacac atggtttgct ccgctaccct 2376181 agtttctcta tccttttctt caatcaagca tttgagggta gtattcaact acaatttacc 2376241 tgttaaaaat tgggcctcac caagtccaaa actccagtca gcattatcat tttcaacaat 2376301 agatacaatt aaatcagttg atgcgatacc acactcagat tccagtcttt cagctaacag 2376361 cctgtaaaat ttttgtttct tctcttccgg tcgggattta cttgtaactg aaagaacaac 2376421 aagattttta gttcggttaa atcctaaccc agtatcctca ataatcatat gattttctgg 2376481 atgttcatga acaatttgat aacggtcttg ttgaggcaca tcaaaagcct ctactacaac 2376541 attgtgagcg acatctaaaa gttttttcaa acttgattga tctcgccctt ctattaagtc 2376601 aaaacgaagt aatggcataa aatcccctcc ttctactaca acagtctttt taatttcatt 2376661 cgttaatgtg tcagctattt ccaagcagct gctacattta gaaaataaag taatttccca 2376721 ataacccctt cattctggtg ttagtcaagc ctatgttatg atgtgtattt ccataggcaa 2376781 tatacagaat caacttcgag taattaacca ttttttgaaa tagctttatc acttacttta 2376841 gaaatcattt attcttctaa gctttagttt acatgaagct ctgctatcat atataattca 2376901 aaattaagat ggaagacatc tcaaaatcag atatcaacta tggaggacta gatgaatatt 2376961 cagttgttac aggtttttct cactactgct cgtgaaggca gtatttccaa ggctgctctg 2377021 actttaaatt atgcacaatc gaatgtaacg aataagatac aacaactaga aaacgattta 2377081 cagacaaaat tattctatcg tcatagtcga ggaatcacac ttactccccc agggcaaatt 2377141 cttgtttctt actcagagaa aattctacat actattgaag aagctagagc agccatgggc 2377201 gaatcatccg cgccttctgg gccactgcgt ataggatcaa tggaaacaac agctgcagtt 2377261 tggcttcctc aactccttgc acattataat aacctctatc caaatgttga tttgaaccta 2377321 gtaaccggcc ctacggaaca acaaatacaa gcagttttac attatgagtt aaacggcgct 2377381 tttatttcag ggcctattga acaccctgat ttagttcaag aaaaggtatt ggatgaagag 2377441 atggttcttg ttacaagtgc ttcacaccct gtgatttctt ccattcagga tgttcaaaca 2377501 caaacaatgc ttgtattccg taaaggatgc tcatacagag caaagctcaa tcatatcctg 2377561 caagaagaag gtttattacc tataaaatta atggaatttg gcatacttga agcgatcatt 2377621 ggctgtgtaa gcgccggctt ggggatttca ctgctgcctc gttcaatcat tgcttcgcat 2377681 gaaaaagaag gccgcatccg cagccacact atctctgaca aatattcttt tgtatcaact 2377741 atgtttataa ggcggaaaga cactttaatt acccctgctt tatctgcttt tttaacgcat 2377801 atgagggatc attttcagat aaagaggcca gatcaatcgt aaataaatgg atggaaggca 2377861 tgcttcgcct caaaataccc ctgatcagtt gtctgatata aaaatatagg cgcatctcaa 2377921 tgtttgtata gagcaaaaaa gcaaacttcg gtatgtagtt tgctttttct tcgtgatttt 2377981 gcactctgaa tcgtgaaacc tagtcgatat taggatgtag attttcctca ttcaaagaat 2378041 tttgaacgaa ggtcattgcc ctagacactt ggttgcgtct tgaagttaaa ggctgactat 2378101 ttcctaaagc gtcaatcgct ctcacaacta ttaaatattc acctacagat ttcgggtgac 2378161 aacgggaaga ttgatatttt cggttggaca ggggcagaac atccaattgt aacagttgaa 2378221 gtatccactg atggaggaga tcctgcagat ctgagtgata ttgctgttga ttgatcaact 2378281 tgtttttgtt cggaatatac tcagtatata gccgcatatt cctcctgcaa tagctggaat 2378341 gagccacccc agccctatgt tatacatagg aagaatctga gtgaaaatac gattcacaac 2378401 ttcaattttt attccagccg ccttcaaacc gtcaaatagg ctgatgatga atgcgaataa 2378461 taaactgcct tgatacactt ctgtcttccc tttaaataca gaatgcaaaa acgttaaaaa 2378521 tattaaggaa atcgcgatag gatacatcgt cagtaagaca ggcattgaca ccttaatgag 2378581 ctgggttaat cctatatttg cgacaagcgt actaaacact gataaaacga cagcaatttt 2378641 tttataagaa atgttcggaa ataattcatg aaaaaatgaa gaacacgctg tgatcagccc 2378701 gacacttgtc gtcagacacg ccactgtaat cattaagccc aataagattg aaccataaga 2378761 tccaaaataa taggatgaaa ccttagccaa aacctctgct ccattttcta aaatccccag 2378821 ttcttcaacg ctggaagccc ccatatagga aagggctgta tacataactg ctaagagtac 2378881 agctgcaatc gcggctgctt ttgcacaaac aactatcagc tgttttttgg tagaagctcc 2378941 ttgttctttc aatgcattca cgatgataat tccaaaaaca aatgctacaa gggcatccag 2379001 agtgaggtat ccttcctgaa atcctttaaa aaacgcttgt gatgtgtacc cttttgatgg 2379061 tgcttgaatg gttccaattg ggcgaataag agctacggct acaagcaatc cgataaatgt 2379121 cagcttaatt ggcgtcaaaa atttaccaac tatatcaatg atttttgaag gattgagtga 2379181 taacaagcat gccaatgcga aaaataatat tgtaaatatg atcaatgaga cagggcttgc 2379241 atcatttgat aaaaaaggtt ttaccccaat ttcaaacgat acgtttcctg atctcgggat 2379301 agcgaaaaaa ggcccgattg ccaaatagag aatcgtcgta aatacaatgc caaacaccgg 2379361 gtgaacacgg ctggctaacg actgtaagtt ttgtttaccc gaaaaaacaa atgctgttat 2379421 agccagtaat ggcaatccaa ctccggtcac taagaaacct gcattagcga cccatacatt 2379481 tttcccggcc aattgaccaa gcataggcgg aaaaatgaga tttcctgctc caaaaaacaa 2379541 tgcaaatagc attaatccta taatgatgat ataggaagca gacacttttt ttgacattat 2379601 atatcctccg attaaagtag acacttcttg aatagccagg aaacattaca gatgctattt 2379661 gcactggcac agtgttgatt ccaaaataag cttgtgtcag ttttatatat ttttatcaag 2379721 ttaaataaaa gcatgatcat tttgatcgtt tccgatatcg gttaaaaaac caattgcacc 2379781 aaaaccatat aaacaacggt tccccccgct atggaaagaa gcatattttt cttccacaag 2379841 tgaagcagta caacagcagc tgctccaacc aattcaggaa tgccatgact tccagaaagt 2379901 agactcacat ctttcaaaca ataaatgact aaaagcccga ttaccgctga tggcagcact 2379961 ttaccaagat actgtacata tttcggtgtc ggtttgccag acgggaaaat catgaatgga 2380021 aggaaccgtg tcagcattgt tccaagcacg accattgcga tggtgatcat ttgctgcgtc 2380081 atagtcatcg tcatacggaa acctcagctt tctccaatgg ttttctcaga acagtcagta 2380141 cccctaaaat ggcgagcata gcaggaataa taaattggtt tccgccaaaa aggataagac 2380201 tggctactga aagtccaagt cccgtgagag cactgtaatg ctttttctct ttcatccatt 2380261 gttctatgaa tatcacaata aacagagcag tcatcacaaa atcaagccct tcggtattaa 2380321 acttcacgta cgacccaaaa atacctccta tcgctgcccc cgcgacccaa tataaatgat 2380381 taagcagtgt cacaaaaaac ataaaccagc ccttatcaac attcgccgga acattagcgg 2380441 tataattgat agaaaatgat tcatcgcaca ttccgaaaat cagataaagc tttttctttc 2380501 cagtccccct gtacttatcc aacatggaaa ttccataaaa caaatgccgg gcattgacca 2380561 ttaacgtcaa aaaaagagca ttcatagggt tgaacgcacc aagtaaaaaa ttcgctgcaa 2380621 caaactccat tgagcccgca aatatcataa aactcatgat gattggatag attgcgctaa 2380681 atcccaaaga atgcataaag atcccataag ctatccccaa aaataaaaac cccgcaaaaa 2380741 tcggaatggt atatgggaat gcagaacgaa atgcagccca tatttgactt ctcttattca 2380801 tatgagtgtt tatagcagga gagcttaaat gtaacgattc tttattttta ttcaaatcaa 2380861 caacctccta catttcatca attggcacac tgacagttct tttttctgta ctcatgacta 2380921 tgcttgtgtc aactccacta atagcagggt tctgcattaa tgaatcaatg ataaaattcc 2380981 gataactctc catgtccttc gccacaatct taagcatata gtcatggctt cctgtaagtg 2381041 tgtagcattc ttgaacctgt gggaatttgt ttatatcctc taaaaatgaa tgaattgtct 2381101 ccctatttaa gggtgataag ttgatgagag ctagtgctgt gacttcgatt ccaagttttt 2381161 tctcatcaac aatagtcgta aactttttaa ttatacctgc ttctactagg ttctttgttc 2381221 ttgcaaggca agctgatggt gaaagcccaa ttttcttaga taaatttaaa tttgatattg 2381281 aagcatcttc ctgcaaatct cttaagatgg ccttatcagt ttcgtcaagc ataataccca 2381341 tttcacaacc cccaatacaa cttaacagaa ttatatttca tacaatttaa ataataacga 2381401 atttttattc gttaatcaaa tattatttaa atttaaatcc ttttaaagta ttattcacag 2381461 aataaaatta tcctcgcgat taactcataa tgaaattaac ttacatcaga aagaagtcat 2381521 gggagagtta tgtacttgtg tgacttgata ccaacatcat aagaaactta tcagaagcca 2381581 aaaagttatt gcggtctcac cgaaaattga atttgcggtg ccctattgcc tttttccgcg 2381641 aacgaaaatt gttaaaattc gcaaaacaga aagtctactc tattattatt ttaaattcgt 2381701 cctttagttc ttcttgagcc tcttgtataa cttctaatac atcgtcagcg tatgaaccta 2381761 aaaatgtatt gctgaactca aaatttttca agactaaagt gagcggcaaa tccacccacc 2381821 ctgtcaggca atcccataaa gcgtctaaat ttctcccata gtagtctggg aagtctagtt 2381881 tatcttttaa atcatcatgt aaaacttcta tattttcaaa gtctcttcca tctattatta 2381941 tttttctcat tagaaactat gccctccatt attttatctt aacaaacgtt tactatgtaa 2382001 cagctgtttg tccaaatgag gctgaaaaca aataaaaaac accgatagga tgaaactatt 2382061 ggtgtttgca agacatcttc atacccggta ggcataaata atgctaaact ttgtttttaa 2382121 aaagctatca tatcaaattt ttatgttaca gcttttacta tcgtttaatc taattgagga 2382181 gtaaaacaag atatgtttga aaatcacata tcccctaaaa attaaaaact aatcggcagt 2382241 tcttcgagtg ctctcatcag aaaattccct ttccatttca tttgtttctt ttcgcctttt 2382301 aactgtatat ttggacagcg gcgtaataag gtggaaatcg caatctttgc ttctaagcgg 2382361 gctagctgtg caccaagaca aaaatgattg ccatggccaa aagcaatatg gcggttgttc 2382421 tttctttcaa tatcaaatat gtcggcattt ggaaatatct tttcatcacg gtttgctgat 2382481 gctaaagaaa tgatgatcac atctttccgt ttaatctcct gcccatgcag tataaacggt 2382541 tcagccgtcc agcgaattgt cgttagctca acagggctgt gaaaccgcaa tgcttcttct 2382601 atggctgaat tcatcaagtc cggctgctgg cggagctttt ctagttgatc atggtgacac 2382661 atcagagcat atgtcatatt ggtgattaag tttacggttg tttcatgacc tgcaacgata 2382721 agcagcataa tcatcgagta caattcttct gtacttaatt gtgtgccttc actttccgct 2382781 tgaattaatg cactgattaa atctcctgca ggttctctcc tttttttgcg aactaaggat 2382841 tccagatatt caacaaactc ccctaacaag tggtcattct cctgaagtct ttcaggggca 2382901 tctgaaaaat caataattgc ttgcgaccat actctgaatt tttgacgatc ttccaaggga 2382961 atgccgagca tttcacttat cacgataatc ggcaatggaa acgcataatc gtctactagg 2383021 ttcatgaatt tgttgggctg cactttatcc aataaagaat ctgcgatatg ctggattttg 2383081 tcttccaact gcaaaatcat ccgatgcgta aatgcttttt gaacaagagt tcgcaagcgg 2383141 ttgtgatcag ggggatctga attaagcata tgttttgtta aagtctcttc attcttcaat 2383201 agagcaggac gtttttcttt tgcggtaaat acattttcat agtttttctt taatttttca 2383261 ttctttaata aatgtattgc atcatcatat ctcgatatga gccagccttt ccccagagct 2383321 cctaaagata atgggtagag agcctgtgat tttcgcaatt ctttataaaa ttcatacgct 2383381 tcatctttaa atgctctcga agacaattga ctttccgtca aaatggttac actctttttt 2383441 tcttttgaag acattcattc gacctccatc tttgaaaggt tatgataatc tttaaatata 2383501 aaatcaggac gatttgtaaa atgatccatt gagatcagta ttcatgataa gggccaaaat 2383561 gccgtccccg cattttgaaa taaaagatat gagacagtca ttaatcattt tgctgcctaa 2383621 actctttccc tgataaaatg gcgaaactcc taatacttct atgccggctc ttttaaggat 2383681 ttggaaaatt ttttagcccc attttgatta atgttatccc ccctgctgct atataatcga 2383741 tcaagtttaa tgtcgggttt atcacgatgt tttaatagag cggcaacaac catttcacca 2383801 ttctgaatgc caacaaaaaa gaaatgcttt ttaaaatatg ctcttgtcag tactttatgc 2383861 atttcaaaaa taaatgaatg atcttttttt cgcgttttac gagtaaatcc ataaaaggat 2383921 attgattgaa agattgatgg aatagctttg ccactttgct tacttcatct gctcttgctt 2383981 gtcgataaag aaacattgat gcacctcctc tgagcagtaa agcaggaaat cgaattaaag 2384041 cgcccttcct attggaaagg cgcctgccgt tttactgtgc caaaatgttt ttcatcagtg 2384101 agtttttata aaatcattta ttaattgatc agttgtcaat attgtggcaa attcatcatg 2384161 caatgtagct agagatatat tatgaatagt cgccgcatca taatatgtat cattttggtc 2384221 tctcattccg aaggctgctg ttgcatctga aatcaggtat gtatcaaacc ctaaattacc 2384281 actcattctt gtggtggttg atacacagtg aggcgtggtt aaaccagtta tgactacagt 2384341 ggttatttca tttaatttta agaattcttc taaattcgta ccaataaagc tgctatttac 2384401 tgtcttggtt ataatgactt cttcatccat aggcttaact atttccttta ttgcaaaccc 2384461 ttcattcttt ggatggaata aagaatgagg tttatcagaa gtgtgttgta tgtatatgac 2384521 tgtccatcct ttttctctcc ataattctag tattttacta atgttttctt ccgcctttac 2384581 gttattccgt tccccccatt ttttatcatc gaaggctttt tgtacatcca caatgattaa 2384641 agctttcttt tcttccacaa gataccctcc tacgtagaat ttctatttat tactacattc 2384701 taaatacaaa ttttactttt gtacaattgt ttaatgatga atttcaaatg agcgccttct 2384761 ttattggaaa atgcgttcta tactgcaact gtgcccaagc cgttaacctt caaatctaat 2384821 ctgagaatca ctggctctac agagaataat aaaaaacact ctaataacga gtgctgaaat 2384881 gaaaaactat tgatttagaa gccatttgat acgctcagct gaaatgatgt agtggagtat 2384941 tataagacat aaaaagacaa tactaactgg ttttaaataa ctaaaataaa gcgctgcaac 2385001 agccattgca aagatcaata attcaataac taaccttgtt actccgttta cagctattac 2385061 agtttgtccg cttcgactag gatcatgagg tactgcaaat acagaccaga caatcataac 2385121 tgcaataggt aaaaccaaag ttaaaacata tttaaaataa ccattaaagc ttatccaagc 2385181 atacacccct aaggagatta gtgcagcaat ttcaagggtg aatcttaaaa gtaaattagt 2385241 ctgattcagt ttttccaact cctctataaa aaacaccccc gcaggagatg ctctttctct 2385301 gctttatttc agcgtataaa aacttttctg ttcttcctct ttagattcta ttgtagtttt 2385361 cggcgagatt acctctactt ttgaagagat gataccgact gctgctgtta ccaatgctcc 2385421 gataatagaa cgatgataag tataatgaaa tatgacaact tttcccctcc tattcagtta 2385481 attatccaaa taatcaggaa gttgtctaca atttgcagaa tttgtcgaac gaagtaaaga 2385541 ttatacctgg gaggctttac tcattgtatg aattacagta aataaattgc cttccctttt 2385601 gagaagacgt tccaactcag ctagactctt ccaataggct tccttttggc gcagctgctt 2385661 ttattcaaaa attgagcaac acctgaatgt ttcattggaa tttctgaacc atcgatcgct 2385721 gctgaatttg ttgcaaatgc atacgtagga gtagtcgaat ggtggttgaa aaatgaaatg 2385781 ccttccccac ctcgagtgat ggcagaaaaa gcgggggttt tgttagagag gaatctatag 2385841 atatgtgtat cgaagatttg acagcattaa aaattatact tacatcgttg ggaacaggcc 2385901 aacaataaag cggaagaacg ttgtcatttg aagtggtttg gaataaaaat gattcgaata 2385961 tgttcttatc attgtaaacg aacaaaaaaa gaacatgttt tgaaaaaaga ttgatcaaaa 2386021 catcttctta tatgttgtca tagcgtaact ttttataaaa aggttaatta cattttcggg 2386081 gcttccaaac caaattttgc ccattcttct tttgctggac cataaatacc tggaacagtt 2386141 aaacctgctt gtctcataag aacagtcatt tgtccccgat ggtggttttg atgttgaatt 2386201 aaaaacatca aaagtgaacc gttaggcatt tgttgtccaa taaagttgat acgttcttga 2386261 agtgtatggt cagtccattg ggtttttaat gcctgtacaa atgcattact ggcttgatga 2386321 tagctgtcag ctataaactg agcagaagtt ggaacaggat aatcttcagc tggggcttgg 2386381 aacgttaagt ctgtgtttga ggtaatgatg ccaatggcag caacagtatg ccaagcaata 2386441 cggcctagag tccaattttg tgaagttatt tcttgtttaa gtgattcatc agtcagacta 2386501 tttaatagtt tctgtgtagc atctgcttcg aactcccaag atttcaaaaa atggtctaag 2386561 gtttgaaaca caaaaatcct ccttttcatt cttttgtttt ttcaatgtgc ttataggtta 2386621 attataatgc ctcctttcgt taaaaagaac aaaaatttcg gacaagaata atcatagtaa 2386681 aatgcgtaga cattcttaaa cgtaacgatt tacgcatctt tttacaaaca tctgactact 2386741 tggtctccat tgtcagcgag aatcaaatat catatgaaga caatcctata ttcttatcac 2386801 tttactgagc aataaatacc ttccgtatac ttagtaatac cttcatcgta atcaggatac 2386861 ttatatgcaa gaccttctga tacagctttt gaatactttc taaataatgc atagcaagta 2386921 aataaagact tccacatttc ctgataccca ttcacagaat atgtagacat gagttcctcc 2386981 cattctttat ttgaaaggta ccgcttcata aatttatagt tcttccccat actaaatgaa 2387041 taccctttct gagatgcgat atgccaggcc atcattctca ataaattagg acgtacaatt 2387101 tcatttaaat ggtcaatggc aaaaaggatt tcatttcttg ctagtccttt tactacgtaa 2387161 gtcgaaacca tccagaactc attacagcaa tcatcaaatt cccttgcagt cggccttttt 2387221 atccagtatt ggcgatcatt tggggtcact ttatagttga tgaacgaatc cttatcaagc 2387281 aataccttaa ccaaaccatc gttattagca aaataatctt ctgcttcacg aattggaata 2387341 agggttagat ctaatttgtt gccatcctca aaaagaataa tgtatgaaaa ccaattacct 2387401 aattcgggag gaaaaagctc catatcttct ggtttttgca tcataatgcg cttcccaaag 2387461 atttcgagcc actgatcatt ttctttaaaa gattctacat cagttacaaa atacgagatg 2387521 tcataatctt ggaagttgtc aggagggata tttctgtttg tacgtgaccc ttccaaagtg 2387581 accaatcgga ttctctcatc gttcaaagca aagtccaaaa aaatgtccat catttcctgc 2387641 tcacttcgca ttacatgttc ctccgtttca gccttaatat ctaactgtaa aacgtcttat 2387701 agattttttt actcttgaat gtgatgtatt cttctaagct ttattttaca tgatgttctc 2387761 ctatatatca ttcaatatta agatgcaaga catctcaaaa tcagatatca actatgacgg 2387821 actacatgaa tattcagttt tttgtagagc cgccatggga cgacactatc tttgacacac 2387881 tttaatcccc cctgctttat cgacatgtta actggtatga gagattgaca aaaagaagga 2387941 aaacgatata tttaagcgaa tacgagtttt tgagtaaatt ttaaaatgac acttttttca 2388001 aaaatcatgt cttaacggga ggattcggta tgaatgaatt tatgaaaaag ttttctttaa 2388061 caaaaccgat tattcaagct ccaatggctg gcggtattac aaagccccga cttgcatctg 2388121 cagtttcgaa tcaaggtgct cttggcagct tagcatcggg gtatcttacg ccagacctcc 2388181 tagaacaaca aataaaagaa atatttgagc tgacagacgc tccttttcaa attaatgtgt 2388241 ttgttccgct aggtctagag atgccaccaa aagatcagat taaaaagtgg aaagaaaaca 2388301 taccgttagc taatcaagta aatcaattca catctgtaca agaagagtgg gatgacttct 2388361 atcaaaaaat tgatctaatt ttaaaataca aggttaaggc ttgctcattc acttttgatc 2388421 tgccgcctga agacgcagta aaggagctaa aaaccgctgg atgctgttta ataggaaccg 2388481 cttcaacagt agaagaagca ttgttaatgg aagaacgggg aatggatata gtagtccttc 2388541 aaggaagtga agccggtgga catcgcggag cattcttacc ttccaaaggt gaatctgccg 2388601 taggtttaat ggctctgatt ccacaagcag cagatgcact gagcgtacct gtcatagctg 2388661 ctgggggaat gatagaccac agaggagtaa aagcagcttt aaccctcgga gcccaaggcg 2388721 ttcaaatcgg ttctgccttt ttaatttgtc acgagagtaa cgcacatcca gtgcataaac 2388781 agaaaatact agaagcaaac gaagcagata caaagcttac gacattattt tcaggtaaag 2388841 aggccagagg aatcgtaaat aaatggatgg aagaaaatga acagtttgag acacaaaccc 2388901 ttccgtaccc ttatcaaaat acactaacga aggcaatgag acagaaggct tcacttcaaa 2388961 ataaccatga tcagatgtct ttatgggcag gtcaagggat acggtcattg actgaggaaa 2389021 tttcggttaa gcagctttta aatcagcttt gccaagagga tataaaaata taggcgcacc 2389081 tcattgatag agcaaaaagc aaactttgac aggcagtttg cttttttttt cgtaatttca 2389141 tccactgact ctggaaatct aaatactcct acattttcaa agctaatttg aatcgggtta 2389201 tcaatcatca cattgatacg atgcgatctt gataatttca ccacaaccac aatacattac 2389261 caacatttcg atcttatctc cccttctcaa gttttgctcc ctattcgaat aatcgatagc 2389321 tcccatatta aatttgaata gtaaaatggt tctttttcgt ttgattcaga tgatataaag 2389381 tcatatgata aaaaaagaat gagacagaaa gcgtgagaag tgatgaaaat aggatttttt 2389441 gattcaggaa ttggtggcat gactgtattg tatgaggcca taaaagttct tccttatgaa 2389501 gattacattt tttatgcaga tacgttaaac gttccatacg gtgaaaaatc aaagggtaaa 2389561 gttaaagaat atattttcaa tgcagctgaa tttctggcca gtcaaaatat caaagctctt 2389621 gttattgcgt gtaatacagc tactagcatt gcgatagagg atcttcggag aaacttcgac 2389681 tttccgataa tcggaatcga acccgctgta aagcctgcta taaataaatg tacagaggaa 2389741 agaaaaagag ttctggtagt tgctactaat ttgacgctta aagaagagaa atttcataat 2389801 ctagttaaag aaattgatca ccatgacctt gttgattgct tagctcttcc aggactagtt 2389861 gaatttgctg agaactttga ttttagtgaa gacaaaatca ttaaatatct aaagaacgaa 2389921 ctatcttctt ttgatctgaa acaatatgga acgattgtgt taggatgcac tcattttccg 2389981 tttttcaaaa acagttttga aaaactgttt gggataaaag ttgatatgat ttcaggcagt 2390041 gtcggtactg caaaacagtt gaaaaaagtt cttgcagatc gtaaccagct tggtaaagga 2390101 tcgggctcaa tcaccttttt caattctggc cataaaattg tggaccaaga agtcatatca 2390161 aagtacaaaa gattgtttga aatattagat gaaactcaaa ggagtcatgt tggacattga 2390221 atgtaaatga aaaagacaat ctcctgaaga gaaacatgaa ctaagaagcg ggcttaaaaa 2390281 gcccactttt tttctaacaa acaattgagt tatacacaca tatctgatta cagtgttttc 2390341 tctctttccc ctcttatttc tcccccctct ctatagcttt tctatttcaa taaaacacaa 2390401 gtctcgattg aaaagttatc gtaacattta cacttcacag gagatttttc acgattgcga 2390461 atcgaccgtt tgccagatgc acaaagtcat aatgtgtaaa ttctgtatct atgtgcatgt 2390521 ttattatgga attattttca taatgtttta taatacaaga tgatagcgtt ttctaattat 2390581 aatgataggg ggaaataatg atgatgaaaa aaggtctgct tgcgggtgcg cttacggcaa 2390641 ccgtgctttt tggcacatgt gcagtagatg taccgggtat tattagtcca aaaaccgcag 2390701 aagctgcatc acagctaact gatggaatcg gcgggagggc ttacttgaac agtaatggtg 2390761 ccattcttgt tacgaaaatc cagcttccta gctccactca ggtttcaaat gggacagcct 2390821 acatctactc tggttttagc ggaggcacag aatccgatat cgggtttcag tacagtgata 2390881 aatataatgt atggaaacca tatatgaaag tcggttcaaa aggacaggat caggttcagt 2390941 acctcgaagg aggaagccaa ttcacgaata cgaaaggctt ccgtcccggc agcaccgtac 2391001 aacttaccat ctacaaaaac cttaacggca atacccgcgc tacatactgg ggcacgaaca 2391061 atgccggata caacggccgt ctcatttcag aaatcagcaa aacaaatgtc ggctccatct 2391121 caaaatggaa agcgctcgct acagttgcaa caacagggtc acgccaatct atcaaatcaa 2391181 acttttcaac atcttttaca aacatcacca tcgacaacaa agcaataaca cctgtaattg 2391241 atacacaaga cttcgctaaa gtaacagtct caggcaacag tgtcagttta tccgttgtca 2391301 aaaattaaaa catgttaaac atacaatgcg ttaggctatt gagaagctct cgatagtctt 2391361 aaagggggct taacatgccc cttttttcat ttcaatttaa ctttcagtta gcttcggtac 2391421 atgccgtcta tccccgtctt ttatctgggt gaagtaaggg cagctcgccc cttctgaacc 2391481 tgttccattt gctcaacgca aaaggtgtgc atcactgtct taaaaatgtt aaaacaaata 2391541 gcagatggtg cactttattt ttagatgagg catgcttacg ctcgatatgc aagtcaaatg 2391601 attaagggtc tgcaagagag agaagttttg ggtgtacttt cataaaagag ggatggcttc 2391661 atatagctcg attgcatcag gaagattagc caacgattgg ccgagaacaa cacatcactt 2391721 tgaaacggat tcattccaaa atcataagta tgatccaata actaataaag atcagttagc 2391781 agtccagcct taaaaatatt tttacatcaa ttaaactagc atcactatcg aataagctcg 2391841 atctgcatat catgtactat cctcttttaa ggaaggtgat gttatgaggt catttccatt 2391901 aatcgtagtt ctattcatcc tattaatcat cgttgggaca tctttctttg gtggctatta 2391961 agaacacacc ttacctcata tccatcagac gccataagaa atctttatgg cgtctgtttt 2392021 ttattagatt taaacaaaac cattaaagtg ggccatgcaa acacacctat ggagattact 2392081 gccacgactt ctttgtgagg gaattattct tccctttatg gactattgtc gatcaaaaga 2392141 gaaagttgaa atgcattttt atggtgagat gaatcgaggc ttagacatat aaaaaaccgc 2392201 aaagctttct tgaagaagct ttgcggtttt tgggtctctt ctttgcttca tataagccaa 2392261 tagatttcaa gcgtaatcca ctgccataca tccaatgatt ttttattttg aaataggttt 2392321 cttctactct tcatgtgaga tgactcaagg tatgccacgt cacaataata tggcggatac 2392381 tgaatggtct caatcagttt tttccccatt ctatcaattc tccacagaaa aaatggctat 2392441 ggcagaacaa ctttcataga gtaatcatca tttaatgagc catcatctca tgggcaatat 2392501 cgtgtccatc catttttgac gggtagtaag taggccagtt tttgacttca tcaagtaaag 2392561 cttcacggtc gtccccccaa tagagatggt aatgactagc tttagtcggg taaatactat 2392621 gatcactaaa ctgaatatac tgaggcagcc cttctgcttt tttagctagt ttgaatatgt 2392681 atcttacccc tctattgccc gcatcatagg ttagaatttc gtatccgtca tacgtatact 2392741 taccagaata ttcttttcca tttttgaaga acgttacagt atctttctgg attacaatac 2392801 ggtcaacatc tgtttgatag ccttttttat aatactcttt atattcttca gctgtcttgc 2392861 cgccttcgtg ttctgattta tatgaaaaca cttcgtcaag agtaccatct tgcaggtatg 2392921 gatatacaga ttgccaatct ccttcccaat cagaaagtaa gcgatccttt acttggctgt 2392981 ttttaaaata gccttcatat attttttctg tttcttcatc atgcgcatga ctatgatcgt 2393041 gagaatgttc gtgtgtatga ctgtcagatg tttgctcttg cgttttggaa gagtcttctt 2393101 caactgctga ggatgatgtt gtttgattag actcacctgc agaagaaccg gaagtctgac 2393161 atcctgccaa aactagtaat gaaccaatcg ttaatatgcc tagccgtttt gaaaataaaa 2393221 tgttcattcc aacactcctt ttttattaaa tcgaaaacat tacgatttat tatacataca 2393281 tctcttgcaa acatcaaagg aaaaatgctc ttcatgcgga tggcctattt taaaggaata 2393341 actgactatg ttcatcagtt attcctttaa aatacgaaag tctacgatat ttccatatcg 2393401 atccgcttca atgtgacagc acccctcaag cagctgtttt aattttccac gtccgcgttg 2393461 tacccttgat tttgctccgg agtaagaaat gccgagcttt tcactcaact ctttttgtga 2393521 taacccctgg aaatcagtta actcgagcgc ctctcgatac ttttcaggca accgtttgat 2393581 ggtcgatcga atacacacag ttgcttcctt ggtgaaattt tcttcctctg cactgtcatt 2393641 aaaatgtaga acatcaggca atatttcgct tgtttttttt gtacggtaaa aatcaataat 2393701 cgtatttcta gtgatccgat aaatccagct gtcgatcttt tgttcatcga tcagatttgg 2393761 gagatgcact tgtattttca taaatacgat ttgcaagagg tcatcaacga tagattgatc 2393821 gttaacccta tgtgaaatat atgtttttaa cggctgatga aattgatccc atagatcctc 2393881 tatattcatt tgaaaaaacc tcctataatt ttgcgtctgc tttacatttg cttcgtcttt 2393941 ttaatcgtaa caaagagcaa acaattgttg aatcaattgt attgcagctg ttgccaaaaa 2394001 taatgataaa ggagaggttt gttgtggagt atacctattt agggagaaca ggattgcggg 2394061 tgagccgttt atgtttaggc acgatgaatt ttggagttga tacagacgaa aagactgcgt 2394121 tccgtatcat ggatgaagca cttgataacg gcattcaatt ttttgatact gccaatattt 2394181 acggctgggg caaaaacgca ggattgacag agagcatcat tggaaaatgg tttgcacaag 2394241 gaggacagcg ccgcgagaaa gttgttctgg cgacaaaagt atatgaaccg atttctgatc 2394301 cgaatgacgg accaaatgat atgaggggct tgtctctata caaaatcaga cgtcatctgg 2394361 aaggatcact gaagcggctt cagacagatc atatcgaatt gtaccaaatg catcatatcg 2394421 ataggcggac accgtgggat gagatatggg aagcttttga gactcaggtt cgctccggca 2394481 aagtagacta tattggatcc agtaattttg caggctggca tttagttaaa gcgcaagctg 2394541 aagctgaaaa acggcgattc atgggactcg tcactgaaca gcataagtat agtttattag 2394601 aacgaacagc tgaaatggaa gtgctgccgg ctgcacggga tcttggttta ggagtagtgg 2394661 cgtggagtcc ccttgcagga gggcttcttg gcgggaaggc attgaaaagc aatgccggaa 2394721 ctcgtacagc aaaaagagca gatttaattg aaaaacatcg tttgcaactc gagaaatttt 2394781 cagatttatg caaagaacta ggagaaaaag aagcaaatgt ggctttggca tgggtgctgg 2394841 caaatccagt tttaactgcg ccgatcatcg gaccacgaac ggttgagcag ctgcgtgata 2394901 cgataaaagc cgttgaaatc agtctggata aggagattct ccgcatgtta aatgatatct 2394961 ttcccggacc tggaggagag acacctgagg catacgcctg gtgatacatt cattactcaa 2395021 tactgacatt tttcttaaat atttatactg aactatcata ttaagaaaga caagagcatg 2395081 tttgtctctt gtcttttcca catcgtgctg aaaatgctgg ctaaacatcg acaaaaatgc 2395141 tgccgcttaa aaaagaaccc taaacaatag agtaactgga aagacaactg gcttgatcag 2395201 cttgggaccc ctttcagctg tatttaaatc aatcaaacta atgattcatt ggcagtctaa 2395261 atattattat tgtttcttta caaaatagta atagcccctg taatgattgc taacaacgta 2395321 ataactaatg atgtaattac agcccactta acggcaaacc tttgaaatga ccccaagtcc 2395381 attttaagca tgcttactag caatactgtt gacgcaacca atggactcat cagatgaacc 2395441 ggctgcccca ttatagaagc ccttgcaatt tctactggtt ctataccata tgctgaggca 2395501 gcttctgcaa agataggtac cataccaaag taatatgcat catttgataa aacaaaagta 2395561 aacggaatac tagtgagtgc tacaataacg gggaaaaacc ctcccattga tgaggggatg 2395621 atggatatta atgatcctgc tatggcatcc accatctttg tcccggataa tataccagca 2395681 aatactcctg ctgaaaatac caataatacc acggttatgg cattaccaga atgctcggcg 2395741 attcgctcct tctgcatttt tacattcgga taatttatag taagggcaag aacaaaacca 2395801 attaaaaata aaactgacgg atgcttagtt ccaagcacaa taaacaccat gatacttata 2395861 acgaggaata aattaagata tattaagcgt ggccttttca attgttcgct ctccaaagta 2395921 gcagccatat aagattgaga gctgtccttt gttatatgtc taggctctaa ttgaacgatg 2395981 cctattcgat tcctctcttt ccttcccatt agaaaagcca gaaatatcac acaagcaata 2396041 cctccaagca tggtcggaag taatggcaca aagaaatctg aaggatccaa acccagcact 2396101 gaaatcgctc ttgtagctgg tccgccccat ggagtcattc cgctaacgat actcaacgac 2396161 agcattgcta atgtcgccat aaccatggga ttcataccaa ttcttttata caaaggtaac 2396221 attgctgaga ctgttatcat ataggttgtt gtaccgtccc catctaaagc gataagcatt 2396281 gccaagacgg cagaccctat cgctattttc acagggtctc cctttactat agataaaatt 2396341 ttttctatta gcggatcaaa taaacctgca tcaattaaaa ttccgaaaaa aagaatagca 2396401 aacaatagca atgccgctga acttgcaact gtttgaattc cttctaaaat catgtcgcca 2396461 atacccttac caaaacctcc aataagagca aaaacaatgg gagtgatggt caaggcaaca 2396521 ataggcgaga ctttctttgt cattattaat attgtaaaaa cagttaccat cgaaaaacct 2396581 aaaatagtaa gcatattaca cctccaagaa tgcgctttca aatgactttt gattaacata 2396641 tcttatacgg tgtaataagt taaataaata tttttttact gtgtttcaaa aaaaattcta 2396701 tcataacttt aaatggttac catttgttca ccctttaaaa aatcaatgaa tgctttaacg 2396761 agtttgattc ctaatgattt ttgatcgtac attagccaag tatctctcat tagaggctta 2396821 cccttagcat tatacagttc cattgtgtac aaatgatcag attcctgcag gcaaatttct 2396881 ggtgctatgg agtaaccaag accatgcttt accatctctt tgcaagtctc ttgtcgatcc 2396941 acttccattg caataatggg ggcttgtttt agattcgtat gcatccaatc ttctataatc 2397001 gtttttaaag aagcatccgt tttatatttg ataaaaggta aaaaaggaag ttgctctatc 2397061 gttattggtt tttttgagat gatatgtaat ttttcccgtg tcagccgttc ctccacccct 2397121 ttccagcgat ggcttcctct cagtataccg acttgtacaa taccagcatc taataatttc 2397181 atgacatctg tgctccagcc tgtttgtaca ctatattgga cattaggata catagtggaa 2397241 aattccctta ataacttagg gagcttatat tgagcgaaat tgcttgatac ccccagcctt 2397301 agatgtcctt gcacctcttt gcttagatta gagatatgat ctttggtatc ttgaagttcc 2397361 tgtagcattc ttcttgcata agcaaccaag tgttctcctt ccgcagtaaa ggtaattcct 2397421 ttatgccttt tggtgaataa ttcaattccg aaaatctcct caatcttttt caaccgataa 2397481 gtgatggaag gctgtgatgt aaataatcgt tctgctgttt ttgttacact ttgttcttcg 2397541 tgaagaattt tcaataaaat ccaatctttc tcatccattt tcatcttcct ttctagtcct 2397601 tctttcacaa ttataaaagt ttttttatcg aatattaaga aaacttatat tttattttta 2397661 tttttttacc ttctacacta aaaaacataa aaaatactac ctttaagatg aggatgatga 2397721 cgatggtcaa gacgaatgta acaatcatga gaggcggaac aagcaaaggc gtttttttcc 2397781 acgaatcagc catgcctaac aataaaaacg aatgggagcc ctttttgctt gatgtcatgg 2397841 gaagtcctga taaaagacaa atagatggtt tgggtggcgg taattccctt actagtaaag 2397901 tggcaataat aaagaaagca tatacttcgg atattgatgt tcactatact ttcggtcaag 2397961 tcagcatttc ggaagaaaag gtggacttta aggggaactg cggaaatatc tccgctgctg 2398021 ttggtccatt tgctattgaa gaaggacttg taaaagcgaa agaaccaatg actgcggtaa 2398081 ggatcctgaa taccaatacg aataaaatga tcattgcgga agtagaagtg gaagacggtc 2398141 aggtcaaata tgacggagat gttacgatat ctggagtacc tggatctgga tctccaatct 2398201 atttaaactt tcatgatgcc gctggttcag ttaccggtca tttattgcct actggaaata 2398261 gttcggagtt tttagataca agtcaaggcc aaatagaggt gtctattatc gactatgcaa 2398321 atccattagt ttttgtggaa gcgagcagta tcggcctgga tggaacggaa cttgcagaag 2398381 aatttactga tctacagttg gctcaatttg aagaattaag atccattgcg gcagagaaat 2398441 gcggctttgc cagtcgattt tcagctacaa agttatcgcc ggctgtcccc aaactggcta 2398501 tagtagcaaa accagagaaa tataaagata gtacaggtgc ttggcattca agcgttgaga 2398561 tggacttaca catcaggatg atgtccatgc aaaagccaca tcaagcactg gctgtcactg 2398621 gagcgatatg tacaacaaga gccctttcag tggaaggtgc aatccctgca agaatagcaa 2398681 aaaaccactc tacaaaggtt cggctagctc attcttctgg tattattgaa acaatggtgg 2398741 agcccactgg tataaagatc gtccgtaccg cacgacgtat tatggacgga acagtttata 2398801 cgcatggaga ctatcaaatg atgtagatgg actgtgcaaa aagcctcccc cctttccatc 2398861 gttaatagat ggattgaatg cgccttcttg cacagatcca ttgtaatctt gcatggcttt 2398921 aaaaaagcct ctatattgtt ttttatgaaa tcgccaaggt cctttcatgt atctgcctca 2398981 agcatgacat aatcattata gagaaaattg aatacttttt actgcaaata aaaagatacc 2399041 aacatcattg gtatctttta gattgagttc atctgcagcg gtttcttttc ctcactgctt 2399101 atttgattac aaaattaccg tactcgtttg aacgaacatg aatcggtccg tttagattat 2399161 agttgttctc cttggcgata gagcgaagca cgtccacacg ggcaactgat tctctccatt 2399221 cgtcacgggt gtcatgattg gccggattca tcagatcgtc atagcgtacg tccaagaatt 2399281 tattcaacca cttcttctcg tctattccgt ctttaggtga tccgcccgct tttttgttcg 2399341 tacgtttaat caaggcataa aaagagtcag ggtcatcacc atcgccatgc tgaataaccg 2399401 tatcgtacat cacagctctt gccaatgctg tttttagtcc ggcattatcc gatcgtttca 2399461 tggcaggctg ataatacaaa tggtcattta ctttgtcttg agcggcgcga aattccttat 2399521 catttgcaag cgacttccag gcagaagcga atcccttgag attgcttgta tcatcgcttt 2399581 cttccttggc cagacggcgc aattcaggca gatacttttt cagtttgtta ttcggaactg 2399641 cctttgtgta tacttccact acttccaatg catccccggt agccgttgta aagcctgccc 2399701 gtccgcatgt atagcctcgc ccgtcatcca atcgctctac atatccatat tggatctccg 2399761 ttgtgccgtt ttcaaagata cttgtcagct gttccgcccg gcgcttttga tctttattca 2399821 gtcccgccgc aaaaaccgtt tcgctcatca tcagggtaaa aaacatggtg aaaacaagta 2399881 atgagatcgc tgcttttttc caaaaatctg ctttttgcat actgattttc atttcacttc 2399941 ccctttctaa atattgtaaa tacagactca gtatacatga agaaactgcc ctattgttga 2400001 aaatacatca atttgtcaat attttgaatc taaagtaata tagcttgaat cttactctat 2400061 tcattgccaa tcagccttag cccctctcac tgggaaggtc ccttgatttt catactgctt 2400121 caactttcat taacaagatg ccataaggct ttactctatt ttataatgga agtgatcatc 2400181 gaaaatcgtt agggaggtga tgtaatggca agcaagatga gaatgccaga ttccgcaacg 2400241 tcccatgcaa agcctactat tgggaaggcg atactttgca tggggtagac tttctaaaag 2400301 atcgcccaag taagcttttc tgatatagtg gctttgcacc ttatttgaca taaaaaaata 2400361 aggagctggc agaaatggca tatgtaaaag caaccgctat tttacctgaa aagctgatat 2400421 cggaaattca aaagtatgtt caaggaaaaa caatatatat ccctaaacct gaatcctctc 2400481 atcaaaaatg gggtgcgtgt tcaggaacaa gaaagctgat cgatgacaga aacgcttcta 2400541 ttaaaaaagc atttaaaaac ggcaaaacca ttcatcaatt atctgatgaa tatcacctct 2400601 ctattgaaac aataaaaaaa attgtctact ctaaataaac aaaacggaag cactgataaa 2400661 aaataatcag tgctttttat atggcgagtt tgtttcttag ttatttcctg catatgatac 2400721 cattggccaa ttgtgtaaag ttaagggaga tgagaagaaa ggaaggtcct acaaatgacg 2400781 ataaacaatg gaacgttgca agtacccggc gcgaacatcc actatcaggt gcgtggctct 2400841 ggtccaatca ttcttttggt ccacggagga ggcggtgatg ccgacaagtt ccatcatgtt 2400901 gccaatcatc tggctaactg gtacacggtt gttacttatg atcgccgcgg ccattcccgc 2400961 agcaatctcg ccaatcagat tgagggttac cgtgtggaaa cacacagtga cgatgctcac 2401021 cgtcttctag ccaaaatcac caataagccg gcctatgtat ttggaagcag ctccggggct 2401081 gttatcgggc ttgatctgtg catacgccat cccgaacaag tacatgtcat gatcccacac 2401141 gaaccaatct tattgcagct tctgcatgga aatgagctga aacaagccga gcaattcatg 2401201 gaagacctta agaaaaatca tcgaagtgaa gtcattaaat taatgtcaag attagagaca 2401261 gacgaacaat caaaggctgt cctgacaaag cggcttctcg gcaattcaac gtatttcact 2401321 gagtatgaaa ttcaaggaat tctcagctat acattagatt tcgaagcatt aaaaactgtg 2401381 tttacatctt caccgatgaa gatactccca gctggcggaa gtgcttctcg ggagcttttt 2401441 ccttatcgtt gcgcgaacgc cctagcggaa caattggaaa cagaatgggt tgaattcccc 2401501 ggaaatcata cggggtacac aatgtaccat aaagaatttt ctgagaggtt acacgacatg 2401561 ttagaaaaag aaaagaaaca tacgtgttaa ggattgatta aaattttcaa aataggacag 2401621 gtgaaactaa ctatggaatt ggagaagatt tcacgaagcg taaaaagaac ttttcactaa 2401681 cgagaacgca atgtgagatg tttaaccaaa gtgatattag ggatttcatc gaaaaatagg 2401741 tttgtacatt acgttctcct attgattatt tcctatctta attccgtatt ttataccatt 2401801 agatacaact ctaaagcggc tcgttatttt gtcctcaaca acaaccagtg tctaacatca 2401861 tgaatctctt ttgaaaatca ccacaaatgc aggtatggaa gacttcatcg cagcaaaaac 2401921 cataccaact attgttgttg gtatggttcg tcctagatag gcccttaaga agagattcta 2401981 ttgtacggag tatttagcta attgcatttg taaccgacag ggccgtctga acctgtgtac 2402041 acatatgtgt cagacacata tccaatattc acgacacccc gggaatcttt ccactggatt 2402101 tggtcccaga tattactcgt tccatacttc cctgtaacag tcgttccata agcgtaacaa 2402161 taataaggaa cacgggagcc actcggaatg gaaagcataa taggataatt tgtaccagga 2402221 ccgctgcgca tattgacagg cgcaccgctg cttgttgaga cagtaaagta ctgaacggca 2402281 agtgcctgac tggaaaaaat gaataaagat gcaatcatca cggttaacat actcagcatt 2402341 ttcagtttag tcaatgtcat ccctctttct tcaattcctt cattttaaga aacgatagaa 2402401 cataggctac cagctgcatt taggaacaac cggaccgtct gagcctgtat acatatatgt 2402461 atcagagaca aatccaggaa cgatctcccc gctggcaagc gtccgctctg tgtaattcca 2402521 aatattgctc gttccatact ttccagttac agttgtaccg gttttgtagc aatagatcgg 2402581 gatgcgggtt ccgctcggaa tggtcgttac aattccccaa cttgtacctg ggccgctgcg 2402641 catgttgaca ggagcaccgc tgcttgttga aaccgtataa tactgagccg caagtgcatg 2402701 gctagaaaaa atgaacacag atgcaatcat caccgttagc atacttagcc tctttaactt 2402761 attcacctta taccctcccc ttataaatgc cgtacgtttg actttcttac atccagttaa 2402821 ggatttactt tcagatacca tgccccctcc cctcccatat atttatcaat gtaccataaa 2402881 ctagatcttt caaaagtgga attattccta tgttttcgac aattaaggat acaaaataaa 2402941 tggtagtcag gcttgatatt gatggtgtgt tacatttggc tcttaatcat ttgtccagtc 2403001 ggtaatcacg attgacaatc aggaaaaagg acatggatca agcggcttcg tttccaccaa 2403061 ttaactcaat cagtgtactg cttccttgta tccacgcttc ttctcgattc atagatactc 2403121 cacctttttc accaatcaaa aacggacacc atacaaatca gcgtaaatgc tgcaagttca 2403181 gtgtccgcaa cctattatga ctttgctttc ttttaccagg gcgtgtaaaa atgattaggt 2403241 acgttatcaa acgttattct atgattttgc gagtcaaaaa atcataacat tttatatatt 2403301 tcaatcagat tatgatctgg atctctgaag tgagcaactc gggcactcca ttccttgcga 2403361 tcatgcggtt tattctcaca tttaactcct ttttcgtgta aatcgtcata cgttttatca 2403421 acatcttcta ccttaaactg aagcaaaaat tttgattgag cttctccttc caaggacttt 2403481 ttttcctctc caacgatttc agccatcgtt tctcgagata aaagctctat tttcgtttcc 2403541 ccattatcaa agagtgcata ttccatttca ttctctaacc aacttattgg aagtcctaat 2403601 gaatctttat aaaactcgac gcttttctta aaatcattca ccaacagtct aatttgtaac 2403661 agcttcatat cgagtgcctc ctataaaacc atacttttac tggtcatcca atttaatgat 2403721 accaaagaaa cctgacagca ctatgtcaag tttccatact tcacccttat ttcagattta 2403781 agtgcagttt agtccatgtc ataagaacga gcaaaaacag cgattcttaa aacaaaaaat 2403841 gataccgagt gtattttctg tatgcttcaa cttcatttcg ggaaatgtaa cgttgataaa 2403901 aggaggttac atcaatatgg atcatcaaac attggcagct catgaggctg ttgacttaca 2403961 tgaaatcgtg aactttaaaa cactttgtat agcgaaatca aagttaatgc aagggcttgt 2404021 gtttgaccaa gaactgaagg acttgatgga aaaagatgta cagcaatcca ttcaagacct 2404081 tactgaatta caagcggttt atgagcgtgc ctcatttcag gcccctgtcc ctcaaagccg 2404141 cccaacgcca atcatcaatt gaaagggagg taagcctctt tgaataatga tcatttagac 2404201 cccattaatt cgctgaatgt gcctgaacta gcagacacta cattcgcgat ggattttctt 2404261 atacgagcta aggaaggcgt aaggaatact gctgtagctt tgacagaaac cgcttcacca 2404321 gatgtaagag cactgcttcg gaaacagctg atgcaaggaa ttgcgatgca ccaagagatt 2404381 acggaactga tgatcagcaa aaagtggttc catccatatg agctgagcga acagtataag 2404441 ctggatcagc tctctgcaaa aaacacgatc atggtcggca atatgaacct ctttcctgat 2404501 gaaacaaatc gcaaagggat gtttgaccgg acacctgatg aacactaaca ctggaggttt 2404561 tacagcatga aggcagtaac gtatcaaggc attaaaaatg ttgttgtcaa agatgtcccc 2404621 gatccaaaga ttgaaaaatc cgatgacatg attatcaaag tcaccagtac agccatttgc 2404681 ggatcagatt tacatttaat ccatggattc attccgaata tgcaagaaga ctatgtcatc 2404741 ggccatgaac cgatgggaat cgtcgaagaa gttggttctg gggtgactaa actaaaaaag 2404801 ggagatcggg taattattcc ctttaatata gcatgcgggg aatgcttttt ttgtaaaaac 2404861 cagctggaaa gccaatgtga tcagtctaat gacaatgggg aaatgggtgc ttatttcggc 2404921 tattcagggc aaactggcgg ttatccaggc gggcaagctg aatatttaag agtgccgttt 2404981 gcgaatttta cccattttaa aatccctgaa tcttgtgagg aacccgatga gaaattaagc 2405041 gtgattgccg atgccatgac caccggcttt tggagtgtgg ataatgccgg cgtaaaaaaa 2405101 ggcgatacag ttatcgttct cggctgcgga ccagtcggcc tgtttgctca aaagttttgt 2405161 tggctaaaag gcgcaaaacg cgtcatagca gttgactatg taaactatcg cttacagcat 2405221 gcgaaacgta caaacaaagt agaaatcgtt aattttgaag accatgagaa tacagggaat 2405281 tatttaaagg aaatcacgaa aggcggagcg gatgtagtca ttgacgctgt tgggatggat 2405341 ggtaaaatga gcgatctcga gttccttgcc agcggcttaa agcttcatgg cggaacgatg 2405401 agtgcattgg tcattgcttc ccaagctgtt cgcaaaggag gaaccataca aattacaggt 2405461 gtgtatggag gcagatataa cggttttccg ttaggagata ttatgcagcg aaacgtcaat 2405521 atacgctctg gacaggctcc agtgatccac tatatgccgt acatgtttga actagtatcg 2405581 acaggcaaaa ttgatccggg agatgttgtc agccatgtcc tgccgcttag tgaagccaag 2405641 catggctatg acatttttga ttcaaaaatg gatgattgta tcaaagttgt gttaaagcct 2405701 taaaaaacgg aggttacaga aatggaatac gccttacacg aagtgcttga ggttcaggaa 2405761 atgactgcat ttaagacact ttgtttgacg aaatctaaaa caatgaaagc actggtatct 2405821 gatccgaagc tgaaagaaat catgcagcaa gatgttgata tcaccacacg ccagttgcag 2405881 gaatttgcct ctattttatc taatgcaaag caagaatgag gagatgaata aatcatgaat 2405941 cctatcatag aatatctgac tggcatgaat gttctaacag accaaatcat tgctatggac 2406001 ttattaattt cagcaaagaa cggagtcaga aattatgcga tggcagccac tgaagccgga 2406061 acgcctgaag taaaagaggt ccttatccgc catttggaag aagcactcga tatgcacgaa 2406121 caactctcaa gctatatgat ggaaaaaggc tggtaccatc cttggaaccc tgacgaacaa 2406181 gtcaagctga atttaaaaaa tattgataca gccattcaat tgccaaccct ttaacataca 2406241 atgactgatt tgctgaggaa cagtattgat tggccacaac tgttcctcag cttcaaaatg 2406301 agcactgttt gttcgggtcc tatgaccgta aatagattaa ccgcttttct ccatctgatc 2406361 tccgataatg tttgcaaatt ctccaatcca aataaggaat cgtaaccacc tctttttatg 2406421 cgatctcttg atggagaaaa caggccagaa acaaaatcct tcgtttttga cctgccctct 2406481 tcacacgcaa agaatgctac cttctttgct ccactgatcc gtgaagactt tccgttttag 2406541 gcctgctttt gagctttgcc tcattttcac gcaatttccc atcataatct ttaatttttg 2406601 tgtctaatct cttaattgtt tcatcaattt ctttccgctt ctctatcagc cgctgtcgtt 2406661 cgtcagccag gatatttttt cgagcttcta ccgtacggtc accttcggta aataatgttg 2406721 tatattcaat tagcgcttct atcgatagtc ccgcatttcg catgcattta atgaattcaa 2406781 tccatttgat atcttcttca tcatagtcgc gaatgccgct gtcttttcgt tttacaggcg 2406841 ggattaatcc tacacgttcg taatatcgga gtgttgcggc tgtcaggcca aactgctttg 2406901 ccacctgagc aatattcatg atcttcacct ctctatcctg tatgttgtga aggtaacact 2406961 taaagttaac tttaagtcaa gctcaaaaca agtggttagc tgctgaatct gggtttatat 2407021 attcgggact tgccttaaag cacactttaa actctatact tctccatgca ctaaaaacag 2407081 tgtagttgga gggattgctg aatggcaaat aaacacactg ccggaagaga acaattagga 2407141 gaatttgcgc caaagtttgc tgaacttcat gatgatgttc tattcggtga catttgggca 2407201 agagaagaag aactttcatc ccgggatcgc agcatgatta cagtttctgc attaattact 2407261 gactgtttct cagcttataa atcaggttca ttttaaatgg tttttttaaa aaacccttgc 2407321 cttaaagcag actttaaggt ttatcgttat gttgaagaca ccataaaaca taaataagtg 2407381 catgttttta tttacaacac ttatgatgaa gaaaggatag gttcgtatgt gtaatcaaca 2407441 tcaaacccgt gtattaagcg tgtcacatgc aaaagccaaa tttgaacaaa cgacgattga 2407501 gcgaagagga ttacggccgc acgatgtctt aatcgatatt aaattcagcg gcatttgcca 2407561 ttcagacatt catagcgctt ttgatgaatg gggcggtggc atcttcccaa tggtgcctgg 2407621 acatgaaata gccggtgttg taacagccgt tggaacaaaa gtcaccaagt tggctgtcgg 2407681 ggaccgcgtt ggtgtcggct gttttgttga ctcttgcgga gaatgcgaat actgtctcaa 2407741 cgcagaggaa caattctgca cgaagggtgt tgttcaaacg tataactcag tagactacga 2407801 cggaaacccc acttatggcg ggtacagcca aaaaatcgtt gtcactgaca gatttgttgt 2407861 tcgcatacca gatcgtttgg aaatggatgt tgccagtccg ctgttgtgtg caggtatcac 2407921 aacgtattcc ccgctgaaac actggaatgt tggccctggt aaaaaggttg cgattgtagg 2407981 cgtaggtggc cttggacatt tggcaattca atttgcacat gcgatgggtg cagaagtaac 2408041 cgtcctgagc cgttccatga ataagaaaga ggaagctctg gaactcggtg caaatcatta 2408101 ctttgcaaca agtgacccag ccacattcac tgcattggcc gggcgttttg acgtgatctt 2408161 aaatacggta tcggcaaatc tcgatgtaga tgcctattta tcaatgcttc gtatagacgg 2408221 gacacttgta agcgttggag ctcctgccaa gccggacaca tacagtgtgt tttccctaat 2408281 catggggcgc cgcagcattg caggttctct agtcggcgga attcaagaaa ctcaagagat 2408341 gctggatttc gcagctgagc atggcatcga acctaaaatc gaagtcatcg gagctgacca 2408401 agtggacgag gcatacgaac gtatcctccg aagcgatgtc cgttatcgat ttgtgattga 2408461 tatttccaca ttgtaatagg ttagtcctta tatgggctgc cgcttttatt gaaactcacg 2408521 aaaaatgatc tctttaagca aatattttga aggccggtca atcttcctgt tattctatga 2408581 atagagagtt attaggaggg ttttttatga gcaaaaaaat tgcagttctt gttacagacc 2408641 aattcgaaga catcgaatat acaagtccgg taaaagcata cgaagaagct ggctacagtg 2408701 ttgtggctat cgatttggaa gccggcaaag aagttaccgg taagcatggc gagaaagtaa 2408761 agattgacaa agccatctct gatgtggatg caagtgactt tgatgcactt ttaattcctg 2408821 ggggattctc tccggatttg cttcgtgcag atgaccgtcc gggtgaattc gcaaaagcat 2408881 ttgtcgaaaa caaaaaacct gttttcgcaa tttgccacgg cccgcaagta ctgattgata 2408941 cggatcttct aaaaggcaaa gatatcacag gctaccgcag catccgcaaa gatttaatca 2409001 atgccggtgc aaactacaaa gatgcagaag tagtcgtcag ccacaacatt gtcacaagca 2409061 gaacacctga tgatttggaa gcatttaacc gcgaatcttt aaacttgtta aaataacaag 2409121 aaggcacaga ctgttcgggt ctgtgccttt tttaaaatta agactccttc gttacattct 2409181 gaaagacagc agtcgcgtcc cacacattca agccaaattg gccttctgaa aatacggaat 2409241 catgtgcatc aatcacaaga cgatcatcta aatagatttt aaagcgatcg ccctcggcct 2409301 ctgttttcag atgatacttt ttattaacgt ctatcggtgt tttgtattca gcaatgacag 2409361 aagcagcacc gttctcaaat ttaaagaatt tcactaggtc atgcttcgca tccacattgg 2409421 caaggtaacc gtttttggca tctttgtcag agcgaaacat tagtgctcct gcccctcttc 2409481 cgtttccatc cttaatggtg atatcagatt cataagtgaa gtctgacccg gatgctgaag 2409541 acaagataaa ggaatcgccg tccgacctcc cttgtttccc ctcaattgtg tctgcccacg 2409601 tgccatttac agtcgtccag ccagtcatat tggacataaa aggtgtcgtt ccccatacct 2409661 tttttaaagg gtgtatcgtt aaagatttta cctttacacc gccatttgca gcatataatt 2409721 caagcccttt gcttgatcgg tctgggagaa taatatccgt tatgacctgc tttccgtcat 2409781 tcccaaatac ttcaaccgag gagcggtcaa caaaaatgcg caacttaacc ttcccattta 2409841 ccggcttcaa cggggctgtt tcttttccgg tgttaaaggc cggattaaag gtgtcgttgc 2409901 ctgactcgct ccggtcaacg aacaatttgg cgttccttcg gtcatagccg accttcgtaa 2409961 attgattttc acctgttcgg accttaaaac caaattcagc agctgaacca gggcttactt 2410021 taaattctgc atttatttca taggcatctc cagattgccc cgctaacaca ttatgacttg 2410081 caggcgatat ggtcagattc ttccacttct tagaggttcc gcgaatggtt tccagctctt 2410141 tcaccggtgt ttggaccact ctaacccctt cggtaaacgc tttcaatttt aactctcttg 2410201 gaatggacgt tgcacttctc catggggatg tcggaacatc attcgcatat tgccaattgc 2410261 tcatccaccc taaccatagc cggcggctgt ctgtggatgg aatatcagac caggatacag 2410321 ccgcataaaa gtctctgccg taatccgtcc agagaacttt gtttggcggg ttttcatttt 2410381 taaaatgagt tccatcaaag tcccctacaa aatattgcat gcctgatcct cccgagaccg 2410441 ctccgtttcc gacactgacc tgcatgaccc atttcttttg attcggattg ccgtctaccg 2410501 gaagctcaaa taaatccggg cattcccata ctcccccgtg gcttccttga tcctgtccaa 2410561 attcacttgc atacgtccac tgcttcagat tttttgatgt ataaatgagg attcggtcac 2410621 cggccgcaag caccatcacc cacttttttt ctttctcata ccaaaagact tttggatcgc 2410681 gaaaatcttt tttacccggg tttggaatga cagggttgcc agcgtacttc gtccatgttc 2410741 ttcctttgtc gttgctatag gcaatacttt gcacttgatg gccttcccga tcctgtgtat 2410801 aaatggccac aagcggcttc tctttgcctg tttgaaaacc gcttgtgtta tttttatcta 2410861 caactgcgct tccagaaaag atcgtgcctt tttcatccgg atacagcgca acaggaaggt 2410921 gttcccatgt aaccaaatct ttgctgacgg catgccccca atgcatgggc ccccactgaa 2410981 gcccgtatgg atggtattga tagaacaagt gatattcccc agcataatat accattccgt 2411041 ttgggtcatt catccagttt gcctccggtg tgaagtgata ttgaggacgg taatcctcat 2411101 catagtagct tgaatcggct gcatctgccg aaaatgccat agtcaacagc agggtgaaca 2411161 tgatcatgac ttgaatcagt ctctttttca tttgttcctt cgctcctctc ttcatgtttg 2411221 aacactttca aaagagactg ctgcgcaagc tggtccgttt ctggcaattc tcctctgttt 2411281 cactgttatc cgaatgattt atatatgaaa agactgctgc agtttctctc tctttccttc 2411341 acacacctta tgctaagaat ccagcccaat acccgagaat cccgatgaca aagatgccgc 2411401 aaataatgag aagtggattc acccctttgc gaagcatcca tgccaccaat aacgttaatc 2411461 cgagaggcag cgcccccggc ataatgctat ctagcacgtt ttgtaccgtt tgaacatcta 2411521 cttttccgct ttcatcctta atcctggata caacgattgg aatgttgatg gtggtccatt 2411581 tggacacgag agcccccata acaaataacc cgagaatcga agcgccctct gtaagctttt 2411641 gaatgcgatt ccccgctaaa tcctgaagaa tctccattcc tttcacatag ccatacttta 2411701 atccgtaata ttttgtgctt aatcttatgg cattcagcaa gaaaaagaat agcaaaggac 2411761 cggcaatgtt tcctcctaaa gcaagggagg ctcctagcgc agctaagaca ggacgaatcg 2411821 ttccccaaaa aattggatcg cctacgcccg ctattggtcc catcaaaccg attttcattc 2411881 cgcttatcgc ttttccgtca attcctttat tgttcgccat ttcttcttcc atggctgccg 2411941 tcacgccaaa tataggcgct gtcagccacg gatgtgtatt aaaccattcc aaatgccgct 2412001 gtaaggcttc gtttcttttc gctccgggac cgtacaattt tttgatcgcc ggtatcatga 2412061 cataacaata tcccattgcc tgcacacgtt cgaagttaaa ggaaccgagt aaaaaatttg 2412121 aacgaataaa catgctgaaa atttctttct tcgttaatcg tttttctttc tccatttttt 2412181 cttccccctc atcgtttagg catcaagatc atcatcatcg tcatcataaa cagcaacact 2412241 gccactgtct gatgcggccg cgactgctcc gtgagcgctt tgtttttgca tcacctgctg 2412301 gtataaaagc gccagacaga gaccaagggc tccaaatccc actaagttaa aatcggtaaa 2412361 cgccgctaat aagaaaccaa tatagaaaaa tggctttaaa taaggaatat tcatcatatt 2412421 gatcaccatg gcatacccga caaccacaat aatgcctccg cctatttgca gtccttttgt 2412481 aatgacatca ggaatatttc ccaggaacgc ctgaacagcg ctgacactaa ttaaagcaac 2412541 aatcaatgta ggaatcatga cgcgcaaagc ttgaaacacc atcgcggtaa tatgcataat 2412601 ttcaattcct tttatatttc ccgcttttgc atattgatca gcgcggtgga tgaaaaagac 2412661 agtgatcgtc cgaacaaaaa tcgtcagcgc ctgacccgca gctgctaaag caacagcgac 2412721 agcaatccct tcgccaattc cttgatcagc ggtaataact aaaatggttg agatgacaga 2412781 ggcgatcgct gtatcaggtg ccatggcaag cccgacgttc atccagccga gcgccatcag 2412841 ctccagtgtg cctccaagaa taattcccgt ttttaagtcc ccgagcacca agccaaccaa 2412901 cgtacaggcc actagcggcc ggtgtgtctg cccttcatcc aatacacttg cgattccggt 2412961 gattgctgca atgattaaca acaaaataat ttgtaatgaa gacatattct catccccttg 2413021 attattttgt tacgttccgt aaaatctgta caaaatcctc actggcatct gaaggcagct 2413081 gcctcaattc cagtttcacg cccttgtcac ttaatgtttc aaatgccttt atatcttgtt 2413141 ctgtgacact gactgatttt gtgatttgcc tgcgatgatt ttcaaaacgc attcccccga 2413201 cgtttacggt tttgatcggt acacctgctt ctataagaga tacaatatcg gacggatttt 2413261 caaacaagag cattgccgtt accccttcgt agcgcggact atgaaatgct tttgccattt 2413321 tagaaaccga gacggcactc gcctttacat ttgaaggcgc aacagaaagg atcagcgttt 2413381 ttctcatttc gtcctgagca atatcgtcgg agacaacgat gattcggtcg gctgcatgga 2413441 cttttatcca ccttgtcagg atttggccgt gaataaagcg gtcatcaatt cttgctaaca 2413501 caatgttcat cataattcat cctctcttgt atcttgattg gctgttttta ctttttctaa 2413561 atgttcactg cacacttgaa agctttgctg actcattgct tttaagttgt tcagcaaatc 2413621 tttgagagcc agatgttctc tcaggcttaa tacctccagc agaatcggca ggtttacgcc 2413681 ggcagccata tccattcttt gatcctcagc aataaaggaa gctgccgcgt tatatggcgt 2413741 ccctccaaaa atatcgacta aaaaaagcac ttcatgttct tccgggatat ccttgagcgc 2413801 ctgatgatat ttttcttgca gcgtttgtat tccttcccct ttgaaaaacg gcactgcaat 2413861 caggttattt tcttcaccga atatcatccc tgaagactct tttaatgcta tgggaaaatc 2413921 tccatgaccg ctgataataa ctgaaatcat atctattgct cctttcctgt tttgtacatc 2413981 catatataat gcaaggatcg tgccaacaca gttgtgttaa gcgttttcat tgttatttca 2414041 gccaatagca atttgttgtt gaaacactta aaacgaaaaa aataaacctg tattaaaatg 2414101 gtgttccatt taatacaggt tcatatgaaa aaactgtttt taaaacagct ggccatgcac 2414161 ttcttcagca aatatggcgg ctataaataa tttttcatca tcacttatgc gaagtccgag 2414221 cttttcttca taaggggcta atgttcgctc tgtcacgtac accatttcct tcagctgatc 2414281 attgatctct tcttcctctg agaaagcgat cggattctgc ttaattaccc tttcaaaggc 2414341 gaaagccgtg tgcataatga ctttgatcaa aaccgcatta ttgaaaatga cccccagctc 2414401 atcctgaacg gtttgcagcc actccaataa catgtcgatc acatggtggg gattcaagaa 2414461 gacaaggtat tttttcaggc tatcctcgca aagctccctg acaataatat ttgcttcgtt 2414521 caatccattg ctcaaggaga tgcttccttt tgtaatcgcc tgttgaatca gcttctctcc 2414581 ctccccttca attaacactt ctaaagatac atgcggagca ttgattttag ggtctttcgt 2414641 tccgactgtc gcaaggattt catactcttt ttcgatttct tttatgctgt tggccagctt 2414701 aatcgatgat acggtcaata tgtgaatggg ggtatcggag gccttgttta cgatcgtggt 2414761 tagaatgtct tccagctttt tggccgttcc gctacccgtc gtgcagatgg ataccaatgc 2414821 cttctttttg ccggatgccg ctggctgacg ctcccacaac tcgataaaat ccttcgtgac 2414881 cgattgatag atcgcatgca aatttaaatt caaatagttg acctttctga cagcatccag 2414941 caccattgaa gtcgtaacat tgctgatcgt tttaatagaa atgcctgtct tttcctccag 2415001 cctgctttcc agcattgcaa gcgaccccat atctaccagc attaaaacac cttcaccttc 2415061 atcaacctgt ttcatttttt ctgctacgca ttcaagaatg tccgaaggtg aaacagtaag 2415121 cggcatgtca actgctgcaa tcggcgtact ccctagcagt tctgtcgcga cttcaaccat 2415181 tgaactcgcc gtgctgtttc catgagctgc cacgataata ccgactcttt tgttctcctt 2415241 taacgatttg atggaatgaa ttaacatcgt taagtagatg acttctattt caggaatagc 2415301 cactttaaaa tattcctgaa ttttatcttt aaaaatcatc gccacccgat attctttcac 2415361 atgggtatca cgaatttcat ctgtctcctg tgtattcaaa acatcaattt gctttcctcg 2415421 ctttaaaaat gcgtcaatat gcatactcaa gaaataaata aacttacggt caaatgtgca 2415481 atccagctca tgttcagcta tttcttttaa ctgttttgtc atttgaatca catcgtcttc 2415541 aacgaatgtc agcaggttgt ctttttgaaa agcttgatga tgaaaaaaac ttctgacatg 2415601 caaatggaca tcagtcaaga tgtactggtt aatatccttt ttggataaac cttctttcat 2415661 aagcgttttc actttttcct caatcaaatg atataagtta aatgagaggt cttcgtcaat 2415721 ttttgttgtt tcatcttcta caatcggaga gataatcgtt gtaatattga catattcaga 2415781 aatggctttg cttctttgca tgtttttgct gctggacatc cattcttgct tgatttcatc 2415841 aggcagatcg cgaacagtca gttcaataac ttcatttctg tcaaggttat gcaaaaatcc 2415901 gtgtgcgcaa actaactgaa catttgattt cagctgtccg acattcccaa atttcgcaga 2415961 gtgaataagc gcattataga catcgatatg cacactcaga ttcttcttaa ttcgctctgc 2416021 ttctttccct aataaaaacg tcgtcagatc cactctttca ttaagcgatc gttcttcaag 2416081 cgaaggaata tgaatggtca ttgggattct tcgcaaaaac gttttcaata gtgcagaact 2416141 cggattttct gtagtcgcac aaataaacaa tacgttcgat gttcgtttat gttcagattc 2416201 tccaagcctg ttataagaac cgctgtcaat aaaataaaac agcatttctt gtccctcggg 2416261 agggagacgg tggatttcat ccataaaaag aatgccccca ttggcctgtt cgactaaacc 2416321 cgccttatcc tcggcagcac ctgtaaatga accttttttg tgtccgaata attgagaaag 2416381 caataattga gggttgttgt agtagtctgc acagttaaat gtaataaatg gtgcgccggc 2416441 cttcaatatg tcagagtaaa tggcaaactg gtaaattcgg ttcgcaaaaa gggatttacc 2416501 ggaaccagtc ggccctagga ggagcatatg cagaccgttc ggcggataaa agacagctgc 2416561 ttttgcctgg gagatcgctt tcttcaaact cccttttgcc cctatcataa gctctagggg 2416621 attcgtggaa atgtgttgat gattttgctt tgaatttccg gaaaacgcct gaaggtcttt 2416681 cacttccatc atctctgtat cccatttctt gttgaataat ttttctgcta tctcgactgg 2416741 gatgtatctt acaggaaatg ttttaatttt gatgaccttt ttggaccgga cgagattgtt 2416801 caattcaaag ctgacattgg accgctccat tttcagctgc tcggcaatct cctttgctga 2416861 attcccttgt atttttaaaa gatgatctaa ggttgaatca tgaaaattat gcttgagctg 2416921 atggtatatt ttatctattc ttctcacgtc tatcatcctt tgtccttatt agataagcca 2416981 ttaacaagaa tatttcgaaa ctttatagtc cgcgttgaga tttacacgtt taaaaaggtc 2417041 tctatagcag attgacaaag ctggctttta tgcgtatatg tttacatgtt gaatcatttg 2417101 cacctcatat tagtatgata gatgctcagt tctggagggc cagtcccctt caaaagtaat 2417161 aatcagtaaa cagtttatca ttctcgggga atgtaatgat gtcaaaataa tcaatgacaa 2417221 aaaatgaatc ttatagatca tgacaaatta cccaaatata accccttaag ttcgttcaca 2417281 actaaaaaga cggacactct atgtgaccgc cacagtatta caatttgcaa aacttcgtca 2417341 tttttgcaat ccacattgga ggttaaggaa tctgtaagct taaaaacttt atctccgatc 2417401 ctatcgattt gatccccctg ccggcctcaa tcatagtggg tatgcaatta tacaaatcgt 2417461 taccgattaa aactagcctg tcagattgtc caaatgactt tcctgtttta ctctgctatt 2417521 caggtagaat cacgagtgaa aaatagagcc acaagacatg taacagcact taaaatagtt 2417581 ttaaaattta aaaataaaag tatctattct tttaaatgtt ataatatccg ataaaacttt 2417641 actcatcttt ttattactgg aggaaaataa aattgatagg caattctagc aaagacaatt 2417701 ttggccagca acagaaattg tctagaggcc ttaaaaacag gcatatacaa ttaatggcga 2417761 ttggaggtgc aatcggtaca ggtttatttt taggttcagg taaatccatc cattttgcag 2417821 gaccatccat tttatttgct tacttgatca ccggcgtatt ttgctttttc attatgcgtt 2417881 cgctcggaga actgctctta tcaaatgcgg gataccactc ttttgttgat tttgtaaggg 2417941 actatttagg aaacatggca gcatttatca ctgggtggac ctactggttc tgttggattt 2418001 ccctcgcgat ggctgattta acggcggtcg gcatttatac gcaatattgg cttcccgatg 2418061 tgcctcaatg gctgccgggt cttcttgcgc ttattatcct gctgatcatg aaccttgcca 2418121 ccgttaaact tttcggagaa ttagaatttt ggtttgcatt gatcaaagtc attgccatac 2418181 tggctctgat cgtaactggt attctcctga ttgcgaaagg tttttccgca gcttccggcc 2418241 ctgccagcct caacaacctt tggagccacg gcggcatgtt cccaaatgga tggcatgggt 2418301 ttatcctatc tttccaaatg gtcgtcttcg ctttcgtggg tattgaactt gttggactga 2418361 cagcaggtga aacagaaaat ccccaaaaag tgatccctaa agccatcaat caaattcctg 2418421 tccggatttt acttttttat gttggcgcac ttttcgtgat tatgtgtatc tatccttgga 2418481 atgtgttgaa tccaaacgaa agcccatttg ttcaggtctt ctctgcagta ggcatcgttg 2418541 tggctgccag tttgatcaat tttgttgtat taacatcagc cgcatcagct gcaaatagcg 2418601 ctttattcag cacaagccga atggtctatt cacttgcaaa ggatcatcac gcacctggac 2418661 tattaaagaa attaacttct tctaacgtgc caagcaatgc gctgttcttt tcatccatcg 2418721 ccattctgat tggcgttagt ctgaattatt taatgcccga gcaagtcttc acgctgatta 2418781 caagtgtttc aacaatatgc ttcattttta tttggggcat cacggtgatt tgccatttga 2418841 aatatcgaaa aacaaggcag catgaagcga aagcaaacaa atttaaaatg cctttttacc 2418901 cattatccaa ctatttaaca cttgcatttc tcgcgttcat tcttgtcata ttggcactgg 2418961 cgaatgatac acgtattgct ttgtttgtca ccccggtctg gtttgtttta ttgattattt 2419021 tgtataaggt gcaaacccgc agaggacata aggtgaaata aaaaaaagac aagggatact 2419081 cactcccttg tctttttata tgtgtcaaac actaaattaa actttggttt caaatttcat 2419141 tcacttcatt taagtgttaa ctcaaaccag ttttgatgcc gaaacctact aatattattc 2419201 cggtaatttt ttgaaacact ttctggaact tcgagttttt catccatttt tttgcgtaat 2419261 caataatata aacaagaaac aggaaccaca acaccgctaa taaggttagg attgaagcta 2419321 aaatgatgag ctgctggttt atatttccgt tcaaattgat aaattggggc atgattgtaa 2419381 catacaccaa aacagtttta ggattgagaa tgttactgag tgatccctgc ataaaggaag 2419441 ttttataata acgtttcgga gaacttgcca tattttttgc ttgggattgc atgtcatcta 2419501 acgaaaacat acttttagca aaaaaacttt ttacacctaa ataaattaag tatgccgctc 2419561 ccaaatattt gatcgttgtg aaaagaatca ctgactttgc gattaccact gataatccta 2419621 aaatggcaat caccgtccaa aaggaaagtc ctgtcgccaa tccgagaatg ttataacggc 2419681 cggctttcgg accataccta agcgtatttt tcatcacaag catcgtatct gcccccggta 2419741 tgataaccat catggcagcg atcggtatgt atgcgagtaa gctgtgcatt gttctctccc 2419801 cctttaaaaa tcccctcaat catatagtga ctacaaaagt aactacttat aaaagtgtat 2419861 caatgcgttt ggaataaatc aatatgattt gttaaaatag cgattactaa ggcagcgatt 2419921 gctctttata ttggaggata tatgaaagaa aatatgttag acattttaaa aaacctcaat 2419981 tttacagaat atgaatcgaa agcgtattta gcattattgc aagaatcacc tttaacaggc 2420041 tatgccgttg ccaaaaaatc cggagtgccc cgttctaaaa tttatgaagt attggaaagt 2420101 cttgtcataa ggggagatgt ttttgtcagt catggaaata cgcctcagta tgttccagtc 2420161 cccgcaaaag aactgattaa aaaccgccgg ctcaaagcgg aagagcattt tgatcaggct 2420221 gagaaatatt ttgaaaagtt cgagcagacc gcaaatgacc gggaaaacat ctggaatatc 2420281 accggccgca gtgaaattct tgaaaaggtg aaggcttgta tcttatctgc caaaaaaaga 2420341 atcctcttag aaatatggaa agaggatttt aaggagatag aagcagagct caaacaggcg 2420401 gcagaacaag gcgttattgt caccattatt gcgtacggag acatcgtatc tgattttgcc 2420461 aatgtttacc ttcatgatat gagcagtgaa attacagaag agtatgacgg acggtggctt 2420521 gtctatagcg gagatgattc agaagtagta gcgggcattg tctcacttgg caacgacagc 2420581 cgtgctgcat ggacgatgca tgtagggtta gtcatgccta ttactgaagt gatcattcat 2420641 gatctgtacc tcatggaaat tctgaaaaag catagagagc ttttagaaga gagcttcggg 2420701 aaaaatctca tccagttgcg ccgtaaattt tctattcact cagatttcaa aaaacattat 2420761 ttggaataat gtttgtcatc tcttacccca aaaacaaggc ttgtacaaaa caagccttgt 2420821 ttttttatgc ataaaccccc catgctgatt tacttctctc ttttaaaaaa tgtgattctg 2420881 cgcaaactat ttttcagcct gccgcgtcta tcctaggtaa cagcctacga tatacgtata 2420941 ttcaaaaagg agccctttat tgcaatgaag aaaaaacaaa caacaaaagc gttgcttgtc 2421001 acatgcataa ctgaccataa gcaagatttc tacaggttgg ctttcagtta tgtgaaaaat 2421061 caagatgacg cattagatat tgttcaggaa tctataaaaa aagcgctgag ctcagttgaa 2421121 acggtcagga accctgagac gataaaaagc tggttttata aaattttagt acggacagcc 2421181 attgactttt tgcgcaaaca aaaaaagata agagtgatgg acgacgaaac gatagaattt 2421241 ttaagcaaag gaaaggaaga ccattacaag gatactgatc tccatgaagc gcttgacgaa 2421301 ttgccgtacc gctataaaac cattattatt ttacgttttt ttgaagacct caaattagaa 2421361 gaaattgcgg aaattacagg agaaaacacg aataccgtca aaacgcgcct atacagagca 2421421 ttgaagctga tgcgcattca gttgacgaag gaggatcttt cttaatggat aagagattac 2421481 agcaattaag agaagaatat aaaaatgttc agattcctaa agaattggat atcattgttg 2421541 aaaaagccct tcagcaagaa ccaaaaaaga aaagaatcgt tatgtggccg acatcagcag 2421601 caatcgctgc agctatttta ttcactgcgc ttgttaatat caacccggac gccgctcagg 2421661 ctatgtcaaa gatccctgtc atcggcaaaa tcgtcaaagc gatcaccttt attgaaatca 2421721 aagaggaaaa agaccaatca agcattgatg tcaaaacacc tgctttgtcc gggctttcta 2421781 ataaagagct tgaaaacagc attaacgaga aatacttgaa agaaagccag cagctgtata 2421841 aagagtttat acagtccaca tccaaaaaca aaaaagggca tctcagcatc tacagtgatt 2421901 acgagacggt cacagacacg ccagatttac tctctatccg gcgcaatatt gaaacaacac 2421961 aagcatcttc ctacacacaa agccgttata ttacaattga caaaaagaat gatattttac 2422021 ttacattaaa aagcttattc aaagatgagc gctatatcaa agtcatcagt caaaacatca 2422081 aagaacaaat gaaacagcaa atgaaggaag atccaaataa aatatattgg ctcactgacg 2422141 aagatgcaga accgttcaaa acgattcttc ctgatcagac gttttacatt actgaagacc 2422201 ataaacttgt gatctcattt gacgaatatg aagtcgcccc cggctatatg ggcgttacag 2422261 agtttacaat tccaaccggc gtcatttcaa acttgctcgt gggagaacgt tatattcgat 2422321 aaaataaaaa catccatcta agattatgga tgttttctct cttctctatt cgaggtcgta 2422381 accccgctat caaaaacaac gagaatattt gcatactatt ggaggaatac ccatgtatca 2422441 caagacacag catcatcgat acattcctgg acttgatggc cttcgggctt tcgccgtcct 2422501 gtcagttatc acttatcacc taaatttcaa ttgggctaac ggtggtttta tcggggttga 2422561 tatctttttt gttttatccg gatatttgat tacatctatt ctattaccgg catatggaaa 2422621 tgatatcaat cttgattttc gggatttttg ggtgcgccgc attcggcggc ttctcccggc 2422681 agcgtacctt atgatctttt ccactgttgt gtgggtcgta ttgtttgatc gagaactatt 2422741 gcacactgta cgtggagatg cgatctcttc tctcttttat atgagcaatt ggtggtttat 2422801 ttttcacaag ctatcatatt ttgatagttt cggttcccca tcacctctaa aaaacctttg 2422861 gtcgctggcg attgaagaac aattttatat catatggccg atgtttttag ttgttggaat 2422921 gtacataatg aaaagccgcg ccagattggc tgcggtgata tcattgcttg tgctttgttc 2422981 agccgtgatg atgagcgtac tgtatgaacc tggcggagat ccgagccgcg tttactatgg 2423041 cacagacact cgttcgtttg aacttctcat cggatgtgcc ttggctttgg tatggccgat 2423101 gaaaaggctg tcttccaaca ggctgccaag caaactgaag cacactttgc acgccactga 2423161 atttttggca ttttgtattt tagtgttgtg tgtctatttc acagatgaat acgagccttt 2423221 tctttacaga ggcggaatgc tattcattag cgtgactgcc gcaatcctta ttgcatgtgt 2423281 ttgccatccg agcagctttt taggcaatct gctttcatgg aggccgcttc ggtggcttgg 2423341 aacgaggtct tacggaattt atctttggca ctaccctgtt attgtgttaa gcacgccagt 2423401 tcaagaaatc ggaaaccctg ttttttggca tatcgtgcta aaggtcattg tgacatgtat 2423461 acttgccgag ctctcctacc attttattga gaagccgata cggacacagg gatttaggtc 2423521 attttcccgc cgtgttttta tacatagaat caaggaatgg aaaacgacat ctgtcatcag 2423581 caaaatgtca attggtttca ttattttcgc tatacttatt tttgcaggcg ggctgtcagg 2423641 gctagccggc gagcaaaagc accctaccaa atggacctat agctcacaag aaacaaatgc 2423701 tgacaccagc caggcttctg gggataaaaa gaacgctgca gcagataaaa aacacaatcc 2423761 tgaacaaaag acaacagatt ccaatcaggg tcaaaaggaa aacaaagata gtgggcaaga 2423821 gactcataaa aagaaagaca cgcaatccca acagttgaaa aaaccagcag acactgcgaa 2423881 agaagtttta gctataggag attccgtcat gcttgatatt tcttcacacc tgcgtcagtc 2423941 attttcaaat gtgacgattg atggaaaggt agggagacaa atgtctcaag ctttggaact 2424001 cgcaagggaa tacaagtctt ttaatcagcc gaacaaggct gtcatcattg agcttggaac 2424061 caatggctat tttacaaaca gccaaatcga acaactgctt caatctttct caaaagctca 2424121 tatttatctt gtcaatacac gggttccccg ccaatgggaa agcaaggtaa atgaatcttt 2424181 gcagcaacag gcccacgcac atcaaaatgt tacgttagtt gactggcata cagaagctct 2424241 tcagcatccg gaatatttta cccctgatgg tgttcacttg gttcctaaag gggcaaaaac 2424301 tttgactgct cttattgttc aggcgatgaa atcgtaaaaa agagatccta tacagatcac 2424361 ttttttactt tagtttctga tcgttgatta tgtcttcttt cagcaaggca gcccttatgt 2424421 ttacatgccg tttacgtaag ggtaagccaa aattgaatgg agggatgata atgaaaggaa 2424481 atgaagaaca tgacatccaa aaagagttga aacgatatga gctttttttc aaaaaacgat 2424541 ataaggttct ttatacagta aacgatttta tcatcggtgc tatgtttctc gttggaagtt 2424601 ttttcttttt ttatgaccgg ttaatgtcgg cagggatatg gctgtttgcg atcggaagtt 2424661 tgctgctgtt aatcaggccg accattcggc tgattcatga ctttcattac cgtaagcatg 2424721 tggaacagca attcaagcat caatcttcaa cagatgactg atcttaagga ataagaaaga 2424781 acaaaatgcc aaaagcctga gtcgaaaatc aaaaacaaga ctttcagact atttattttt 2424841 aaaaacaagg taaaaagaac taaacttttg cctctgcatg ccgatatgaa taataaggcc 2424901 ggcgcgatac tccctataac atccttttca gtagatttca ttatcgtgcc ggttttctca 2424961 tatgcaaagc aatcccgcca atcagattgg cgggatttta tattttacat tcctgtccaa 2425021 acgtctttca cataacgtct ttgatcttgc agcttttgca gccatacagc tgattcttcc 2425081 tgacttgctg ctttttcagc ttcatatgcc aatcgcaaag ttctctctac atcaggagcc 2425141 atttgcgatc catcaccgca tacgtaaata tgagcccctt tttcaatgag tgtcatcaat 2425201 ttctgcgtat cttgcttgag caagtgctgg acatatcctt ttggttcgtt ttcgacgcgc 2425261 gagtagcatc ggcggattgt gaccaaaccg tcctgttccg cttgatccag ctcttctctg 2425321 taaaggtcgt catggtccgg gcggcggcag ccgaagtata aaagtgcttc accaagggtg 2425381 cttccttcct tcttcaaaac cgatcttgcc tgaataaagc ctctgaatgg cgcaattcct 2425441 gtgcccggcc cgaccataat cataggcgtt tcaggatcat tcggcatctg aaatccggac 2425501 tgcggcgtac gaatgaagca agctgctgca tcacctgtat tcaattctgc taaataatta 2425561 gaggcgacac cccggtattc acctcggccg ctccatgctg aggctttcac aactcctacc 2425621 gtcatgctca cgatatttgc atgaactttc ggtgagcttg aaatggaata gtatctcggt 2425681 tttagtgatg gcaaaagtgc taaaaaccgt tcaaacggca tttcgcaagc aggataatcc 2425741 tctaaaaaat caagcatggt aagacgtttt gcaagtacct gctctttgta aatgccatca 2425801 tctgaaacga gctgttccag ctctttttga tgcggcggac aaactgtata agaggccagc 2425861 tcccgaagct gaagccttga tgccggttcc tgcagctcta cataggacga caataaatcc 2425921 actactttga ttggccgatc catcggcaga tgagccatat gagcgcttcc gcttactttt 2425981 atcacatgat tggactgcaa accgaatcgg ctgagaaccc gctgaacaag ctccctgctg 2426041 ttctttggca ggattccgat atgatcgcct tctttatatg ttttaccagc cggaatttcc 2426101 aattcaatat ggcgggttga acgcgtgctg gcagctgtct ggagttctcg attctctaac 2426161 acaatccctt caaacgcgcc atatgcttta gcaaccggcg tttccgtcgc ttcactgaga 2426221 aaagtaatcg ataatgaagg cctgtcttct ttctgggcta tttcgttaat atcaaatgcg 2426281 tccatcgttt ccttccagaa gcggttttcc caagactcgc ggtggctttc aaaatcatcg 2426341 gcggcgtcac cttccccaat cgctgttaaa cgcgatgccc cctttgcttt catcatgtca 2426401 tcaatcaggc ggggaatccg ctgatacgtg ctggcccagc tccggtttcc gcagccgaat 2426461 accgcatagg aaacaccttt caattggcct tcctcaagct ctttcagcca ctctacaaat 2426521 ccggcagcat tatcaggcgg cgccccatta taagaagccg ttacaatgac gactgcccct 2426581 tcttcaggga gcttgccgat ataatcatca agcggagccg tttcagctgt aaagcccatc 2426641 tggcggcctt gagcagccag ttcaccggct attccctcag ctgtcccaag atttgaacca 2426701 aaaagaacaa gtaaaggtgt gccgtgttta ggtttggttt cttttggctt tgtttctgct 2426761 ttgatgtctg cctgttcttt tctctgtaca ttgattgccg ctgtttttcg cggtttcaca 2426821 gtaattttaa aatcatccgg cttgatcgtt aatgcttctt tgatttttag ttcgtagcca 2426881 gtatggttta tcaattcaaa atgctttaat acaagaccga gaaccattgt cgcttcttga 2426941 agagcaaact gcatgccaat acaagcgcgc tgtccgtttc caaacggctt atacgcatgg 2427001 tgagggatac ttgaaggatc ctcaaaccgt tccggacgga aatcttccgc atccggtccc 2427061 caagcgtttt gatcccggtg cagttttgga attaaaacag tgactggctg ccctttgctg 2427121 atcggatatt ccccgcctag aacagtatcc tccttcgcat atagagaaaa agccggagct 2427181 gttggataca gtctgagggt ttcatttaaa accatccgaa tgtatttgag ctgctggatt 2427241 tgtttatatt caggcgtgtc atccgttaac acgcgatccg cttcctcctg agcttttttc 2427301 agtttttccg gatgtgtaag cagacaataa atcgcaaagg atagcaaccc gcttgttgtc 2427361 tcatgtccag caattaaaaa tgtgatgatt tggtatcgaa tgttttcgtc atccagcgtt 2427421 tcacccgtta ctggatcttt ggcataaagc atgagagaca agagatcctt aatgttttca 2427481 tccggattcg cctttcgctc cgctatcatt ctatcaacca gggagttcat gacttctata 2427541 tccttttgga actgcagctt cgttttcacc atcattttat cttgcaggcc cagtcttttc 2427601 gattgattca tcgcctcttt taaggcacgg agcatactgg tgataaacgg atgctgtgaa 2427661 tcacggtaaa agctgttgaa tcgatagtta aacccgcata acccaatcgt atcaagcgtc 2427721 agacgtgtca tatcgtccgc tacatcaatt tcttcattag ggtttaaccg gctccacttt 2427781 tgaatcagct gggttgcgat atccagcatc atagaatgat agcctttcat cgctttttga 2427841 ctaaaactcg gcagcaaaat gcggtgggct ttttgccagt tcggttcgtg cgtccagctt 2427901 gtaaataagc catctccccc gaactcacgc accttttgca agcctttgcc aaggttcttg 2427961 tcaaagcgtt tttcatcaca cacttcagcc acaagattgt ggccggacac aaaaacactg 2428021 gatactcccg gaaaatcaaa acggaaaatc ggtcccaatt catcagctat ccgccataag 2428081 gattgagaaa gctgttcttt ttccagatgc ggaagatttt ttaaaggtcc gtatgttttg 2428141 ggctgaggta ttgcgcttgc ctgtttcatt aacatctccc tttcctattt ttgtgatgaa 2428201 tgaagcttaa tggcgtccca gcagcattgt tccaattcag taattaaatc agtgtccatc 2428261 tctatatcac ctgtttgaac gagctgatat atcttgagaa acgcccctaa tacaatcgca 2428321 attaacacat tagagggcag gctgcgaatc acgccttccg cttttccctt attaaaatag 2428381 tcatcaagca tttgagtcag attttctatc atttttttgc ttgtatgatt taagtaatga 2428441 gcgtcttttt tggtttcaag aaaaaaaagc gcatagtcgc tctctttcgt aaactgaacg 2428501 agacagcaaa atacgtggtg aaagccttct ctgacaggca attctgaaac gtcttgcttc 2428561 agtttttccg taaatcgctg gatgctttct tgaaacagta cgttaacgag tgtttctttg 2428621 ctgtcaaaat aacgatagat cgttcctgtc cctacatgag cacgttcagc tatcatagga 2428681 atagtggtag cgtcaaaacc cctttccgta aaaagtgaga ctgacgcttt cataatcatg 2428741 tcgtatttac tgctggatgc ggatatcatg taatctgaca acctccgatt cgtttacgga 2428801 atgaatattc attccttttg ttcacaaaga atgtctgccc tgtctgatat cacctctttg 2428861 ttctttcttc tgttataagt ttatatgaaa aaaacttttt ttaatataaa gtatatgcaa 2428921 aaaataaaaa attaagaaaa tatacccaaa tcctaatacg aggatcttgg atatatttcc 2428981 cgagaaattt tttatttaac agccacaata catagacagg aagcacgcct gataacagaa 2429041 agatccctga aatgctggtc tttcagcagt tgaatatacg ttttctcttt ttcaccggta 2429101 tttgtgtcaa tactgatata aaaccggccg tcaatttgaa gcaccctgta aatttctctt 2429161 aatgcaagcc taatatcggt gcagctttga accgtatgta aagaaaagac tttattaaag 2429221 gtacggtcat caaagggaat gtcctctgga tagccatgaa aaacctcccc gttccccatg 2429281 ttctttcgat tcgcacgtga tatctgtctt acctttcgtt ttgaaggatc aatgcttttt 2429341 aggctaccct tttttagttt cttggttatg cttttaaaga cagtgccgtt tccaattcca 2429401 atttctaaaa ttctgtcatt ttcttgtata tctatagagt caatcatcat atgctcaatt 2429461 gttttggtta gcttatattt ccgagaaaat aatttccaaa aatccgatcg tttatagagt 2429521 ctattttcta gcattttaaa cacctgcttt tggtttccta tgtttattta ttatcttaaa 2429581 aaaataaaca tcatcttcat ttctaaaagt gaaggaaggt accaactaga cggcaatgta 2429641 ttgaaaaatg tttcaataga actaaacttt ttcatttttt tccgaaaaaa aagcagaaaa 2429701 cataatgttt tctgccctct ttctaatgcc aatgataagg gaatacatac agcctttgct 2429761 gctgcattgc catcagcctc tgctgtcgga atggatttcc ataaccatgt ttgaaggaat 2429821 gcggcatgga cgcataacca tggccaatcg acggcagtct tttttgataa tcgttcatca 2429881 tgccatcacc tgcctcacaa taacgttgat ttactatatg caggcgcgca ttttcttgac 2429941 agctatttcg ctaaacttgg tccttctcca ttgtataatg catcaatagt tccattctaa 2430001 gcatatgcca ttcccccttc agtttttttc gttgctttta gcgccagttt gttaaataaa 2430061 gatgctttaa ctgagactct ttcatttcat cataaatttg ttcaatctgc tgttctcgtt 2430121 cgaattcttc caggctttta aaccgttttt taatcgttaa cgttaaaaag aataggttaa 2430181 tcgtcatatc gctcaccccc tttcaaagtc cgcatcaagc gaaataaccc gcggcacaac 2430241 ccttctgccg cgggcaaata aaaaccgcag acaaaagaag acaccaatgc ctctactgcc 2430301 tgcggggagt tgcgtatgtc cgactattcc gaatttaatg cgtgcgataa gcatcggtta 2430361 aggaaggaca cgaactcttc cacaggctga ataaaccatg aacttttaca tgtgtatcac 2430421 gtacaggttg acgtcgttgt ctcattgtca ttttggttca gcctcctttg cttttttctt 2430481 actttgtaag tatatccacc aaattccatt ttgtaaacat ctttttctaa aaatggacgg 2430541 aaattgtgca aatcatcgaa tggatttgcc cgttggtcat gacacctgct tcatttcttt 2430601 tctggagcgg tctttcttat gatatgcaat aaaataaatg agaccgacaa atacagctcc 2430661 gccgatgaca ttaccgataa aagccggaat gatgtttccg atgaactgcc cccacgtgaa 2430721 tgagcctgca aaaatggcag caggaatcac aaacatgttg gcgacaacgt gctgaaatcc 2430781 gatagccaca aaagccatga ttgggaacca gatgccaagg atttttcctg ctgcgtcttg 2430841 ggcgccgaaa gaaagccaca ctgcaagaca tacaagccag ttacagccga tggcggaaat 2430901 gagaaccttg ccaaagctca tatcaagctt tccttgggca acggcaatcg ttttttctaa 2430961 ataaggacct gtttcagtca atccaaccaa atgcccgaaa aagtaagcaa caaacaatgc 2431021 gccgattaag ttcataattg tgacgattcc ccagttaatc gctaactctt ttactgatat 2431081 ttttctcgaa aataacgcca tcgcaactga catcatattg cctgtgatca gttcagcgcc 2431141 agcgagaacg acaaggatca ggccgactgg aaatactgct gcaccaatca aactggacag 2431201 gctcccccat tctttcggaa gatcgccaat taccctgata tcaagcaaat acccaagcgc 2431261 gataaatgca ccgcctaaaa accccagcac aagcagtgac ggcagcggga gctttatttt 2431321 tttcatccct gcttcaattg ctgcttccgc tatttcatcc ggttttcgaa aagccataat 2431381 aaaacgcctc cattacttct tcttttctca cagttatgca agaaaggcaa taaaaaaggc 2431441 agcactcaaa taacctgtgt caaaccaggc gtttgaatgc tgcctaactt gtatgcatac 2431501 ccatacaaca atatcaagca gtatataaga tattgaaaga gaatatatac agttcgtgca 2431561 tacattccat tgctttagcc ttctataact gtagcaacat catatcaaat gtgacaaatt 2431621 tgtgtcaatg acaaatatac tagctttgca gagcttcttt ttgctcatct atttttcggt 2431681 caaaaacaaa tacagataca gcgatgtttt cctcaatttt aatatcagaa aacaaatgga 2431741 ctagcttagc tcccataagt tcctccattc cttccggtgt ttgtttggaa taaaggtctt 2431801 gaattaggct tgtccgggcc gcatgtacca tctctcttcc ttcaggcgtg cgggcaataa 2431861 actgctcgct tgcactcaga tttccgtata gtgttgaaac tgccatgttt tctacaaata 2431921 cagtatgaat tctctcaggc ccttttccga acaattcttt gcgaagtttt cgaataatat 2431981 cattgaattc atgaattttt ttagacatgc tgattacccc ttccgatatt gccttataaa 2432041 ggcttttccc ggttcccctc aggacatttc acttggttaa aattttcctg ccatattgta 2432101 ttataataaa tatcacatta taataaaagc agtgttgatg gatttgtaat aggatcttgt 2432161 tatgagtcta tcgttttata aaaatcaagg attggtctgt tagtaagact tgctagtgaa 2432221 ctattccgcc atgtgtgttt acaccttctt agaattaagg gcaggtgtat ctatacatgg 2432281 ctttttttga cttcttgaaa gaaagatgga ggggaatatg aatatgatgg acgttaagtc 2432341 gatcagtgtc cgtgtagacg gaacagaaat tcaagcacga gcaggggcca caattttaga 2432401 tattttaaat gaaaacggaa ttgagtaccc gcagatttgc cacgtaccag aggttgaccc 2432461 gattcaaact tgtgatactt gcatagtaga ggcaaacggc aagctggttc gttcatgcgc 2432521 gacggttgca gaaaacggga tgtctattga tctttcagga aatcgagtga aagaagcgca 2432581 aaccgaagcg atggaccgcc ttcttgaaaa tcatttgctg tattgtacag tttgcgataa 2432641 caacaatgga aactgtacgc tgcataatac agcggaaatg atggggatcg agcatcaaaa 2432701 atacccatac acgccaaaag aagatccttc ttgcgcggtt gatatgtctc atccttttta 2432761 ccgctatgat ccaaaccaat gtattgcctg cggccagtgt gttgaggtct gtcaaaacct 2432821 tcaggtaaat gaaacactct caatcgactg ggaacgcgaa cgccctcgcg tcatttggga 2432881 tgagggagtt ccgatcaatg aatcttcctg tgtcagctgc ggtcagtgtg taacagtatg 2432941 tccatgtaat gcactgatgg aaaaatcaat gctcgggcag gctggtttta tgacaggcat 2433001 taaagaggac gtcatggaac cgatgattga tctcgtgaaa aatgttgaac cggggtatgg 2433061 cagcattttt gccatttctg aagtcgaagc ggcaatgcgt gaaacgagaa cgaaaaaaac 2433121 gaaaactgta tgtacgttct gcggtgtcgg atgttcattt gaagtatgga caaaaggacg 2433181 ggatatttta aagatccagc ctgtttctga tgctccggtt aacgcaattt ccacatgtgt 2433241 caaagggaaa ttcggctggg attttgtcaa ttcaaaagag cggatcacaa agcctttaat 2433301 ccgtaaaaac ggagcctttg tggaatcttc ttgggaagaa gccctcgatc ttgtcgcaag 2433361 cagattagga tcaattaaag agcagtacgg taaaggctct gtagggttta tttcttcttc 2433421 taaaattacg aatgaagaaa actacgtcat tcaaaaacta gcgcgtcagg tatttgaaac 2433481 aaacaacgtc gataactgct cacgctactg ccagtctcct gctacagacg gattgttccg 2433541 cactgtcggc atgggcggtg acgccggcac gattaaagat attgccaaag caggcctggt 2433601 catcattgtc ggtgccaatc cggcggaagg acacccagtg ctcgcaacac gcgtcaaacg 2433661 ggcacacaag ctccacggtc aaaaactgat tgttgctgac ctgcgtaaaa atgagatggc 2433721 tgagcgatct gatctgttca tcagccctaa acaaggcaca gaccaagttt ggctgatggc 2433781 tgttacgaaa tatatgatcg accaaggctg gcacgatcag gcgtttattg atgagaacgt 2433841 caattacttt gaagattata aagaaaccct taaaacgtat acgcttgatt atgcagaacg 2433901 catcacaggc ctttcaaaag aaaacatcat tcaaattgct gaaatgattc gtgatgctga 2433961 cggcacttgt gtcctttggg gaatgggtgt cacacaaaat acaggcggtt ctgatacatc 2434021 agcagccatt tcaaacctgc ttctcgctac gggcaactat cgccgtccag gtgccggcgc 2434081 ttatcctctg cgcggacaca ataacgtgca aggcgcatgt gatatgggaa cattgcctgg 2434141 ctggctgccg ggatatcagc atattacaga tgacaaagca cgcgctaaat ttgaagaggc 2434201 atatggtgtc gagattgatg gaaagcctgg tttagataat attcaaatgc ttcatgccat 2434261 tgaagaagga aaaatgaaag ctatgtatct tgtcggtgag gatatggcac tggtcgattc 2434321 aaacgcgaac catgtgcatg atattttatc aagccttgat ttcttcgtgg tacaggacat 2434381 cttcctgtca agaacagctc aatatgctga tgtcgtcttg ccggccactc cttcacttga 2434441 aaaagacgga acatttacca acacagaacg ccgtgtccag cgattgtatc aggcgcttcc 2434501 gacgcttggt gacgcaaaac cggactggtg gattattcaa gaggtggcaa accgtttagg 2434561 agcgaattgg aattacagcc atccaagtga cattttctct gaaatggcga gtctttctcc 2434621 tctgtttgcc aaagcaagct atgaggtgct tgaaggctgg aacagcttcc tatggggcag 2434681 cttcacaggt gaaagcacac cgcttctgta tgaagacgga tttaatttcc ctgacaaaaa 2434741 agcccgcttt gccctttctg attggaccga gccagcggca tttccggagg aatatgacct 2434801 tcatatcaat aacggccgga tgctggagca tttccacgaa ggaaacatga caaataaatc 2434861 gaaaggcatc caagcgaaag tgccgaatgt attcgttgag atctcacctg agcttgcaca 2434921 agagcgaggt gtttgtgacg gttcgcttgt acggctcgtt tctccgttcg gagcagtcaa 2434981 attgaacgcg ctgatcacag accgggtacg gaaaaatgaa ctctatttgc caatgaactc 2435041 gacagacaag gagtcagcga ttaacttctt gacgggccct gcagctgata aacggacgaa 2435101 cacgcctgct tataaacaga caaaggtccg catggaagtg cttggcggct gtgaaacagc 2435161 gccgcttcca aaaacaaatc cgcgcaacaa aaaacggcat ccgcaaaacg gagtcgaagc 2435221 agaaagaaaa tggaaccgcc ctggctatgt acatctgact gattaaacga taggaggaaa 2435281 acgaatggcc actccgatta cgacgatcaa aaaagaaaca aaaacagctg agcaaattaa 2435341 gcttgaaaaa atagaagaac tgaaagagct gctggcggaa aatgaggacg ccgtctctaa 2435401 aacgatgacg ttaatgaatg aactcaatga tcttggaatt tttgatgcgg caacaagcat 2435461 gctcagagcg aaggaagaca ttgccaagat tgcgcttggc caagtttccc gcgagcctgt 2435521 caccaacctc atcaacacga tgatggccgc cggaggcgca ttgacaaaag ccgatcctga 2435581 gtttacagca aagcttttag aaagcgtaat ggctgggact gaacaggcac aaagcttttt 2435641 aaaagaagac aagaaagtcg ggattctcga cctgttaaaa gcaatgaacg atcctgacat 2435701 caacagagcc gtcgggttcg gccttcagtt tttaaaaggc atgggaaaag aacttcgaga 2435761 acaataacag aaaaacagcc atctctgatg atggctgttt ttttattcgt cggcttcttc 2435821 cagacgcttc ttgtaaataa gtgaacggtc agcgcaaaag aaggcaccgg ctaaaaatac 2435881 gcaatccgct aaaaacatcg tcgatttctg gcctaatgtt aagccttgat cagggagaac 2435941 tgcgcctata tataaaaaag tgctgactgc aagcaatgta aaagcaaaat gcttgtagtc 2436001 ttcttttaaa gatttcattc tatttttgtt caaaagaatc acctgccaga ttcatagtat 2436061 acgactatta taatataatc cggcggctta cagagaaagt aattctatcc atttgttata 2436121 tattttcaag cgcttggccg atatcttcca acaagtcttc cgcatcttca attcctacag 2436181 aaattctgat caagccgtcc gtaatgccga gctcaagccg gcgttctctc ggaatagagg 2436241 catgtgtcat tcttgcagga acagaaatta agctttcaac cgcccccagg ctttcagcaa 2436301 tggtaaacag tttcagattt cctaaaaacg catcaacccg ttcttcactg ccaatatcaa 2436361 aggagatcat gccgccgaag cccgctcctt gcgtttttgc aagctcatgt ccgggatgat 2436421 ttgaagaacc agggtaatat aacgtttgga cagcagggtg attctcaaga aagcttgcga 2436481 ttttccgcgc attttgatcg atcgcttcca ttctgagtcc caacgttttg attcctctca 2436541 ttaacagcca ggaatcttga gggccgagca cgccgcctgt ggagttttgc acaaaatgca 2436601 gctcttctcc aagctctttc gaagctgtca caactaaacc tccgacgaca tcactgtgtc 2436661 cgccaagata ttttgtcgca ctgtgcagta cgatatcagc gcctaaagta agcggctgtt 2436721 gaaaataagg agtattaaag gtattgtcta cgataagcag aacacccgct ttttttgcga 2436781 tatcagccat gagcgtcagg tcggtgattt tgagcaacgg gtttgtcggt gtttcaatat 2436841 aaattgcttt tgtattaggg cgaatcgctt tttcaacttc ttccctgctg ctcgtatcaa 2436901 caaatgttga ttcaatgcca agacggttaa gcacctttgt catcacgcga tatgttccgc 2436961 cgtacacatc atcagtcaac acgacatgat ctccgctgtt aaacagcatc ataaccgctg 2437021 taatggcagc cattcctgag ctgaacgcat agcctgcttc cccgctttcc agttctgtca 2437081 caagtgcttc gagagcggtt cgagtcggat tggccgttct tgaatactcg tagcctgtat 2437141 gctgccctgc tttcggctgc ttgtacgtgc ttacttgata aatcggcacg gaaactgcgc 2437201 ctgttttctc atcacctgtg attccgccat gtatcatcaa tgtttttttc ttcatatcag 2437261 atgcctcctt cgtatatttg tttgctgata tatcgatcgc tgctgtcagg aaatactgtg 2437321 acaatgttag ttccagcgga tgcttttttc gcttcctcca atgccgcata aagcgctgca 2437381 cctgaagagc ttccgatcag caggccttct ttttctgccg cttctttcac aagtctaaac 2437441 gcattctcat ctgttacggt gtagatctcg tcaaaatggc tcttatccat ataatcgggg 2437501 ataaactcca tgccgatgcc ctctgtttta tgagcgtggg gctctcctcc gtttaaaatc 2437561 gagcccaccg gttcaacaat caccgttttg actgctggat ttttttcttt taagaaggaa 2437621 gctgtccctg cgaatgtgcc tcctgatcct gcccctgcga caaatgtatg aatattcccg 2437681 tcaagcgctt cccacatttc aggtccaagc gtcttatagt aagtcgatgg atttactcgg 2437741 tttttaaatt gcaaaacgca ataagaattt tcaatttcag tctccagctg aatggctttt 2437801 tgaatggctc cctgcattcc gtcttgacgc ggtgtatgaa tgattgatgc gccaagcgct 2437861 tgcataattt gctgtttctc tctgctgaaa tgttcaggga cacagaaaat cgctttcagc 2437921 ccatattttc tggcacttaa cgcaaggccg atccctgtat tgcctgccgt agcttctata 2437981 atcactccgc cgggtttcac tttgcctgaa tcgagcgcgt cacgaatcag catatctccc 2438041 agtctgtctt tgatgcttcc ccctggattc atcatttcaa gcttggcata caccgcgact 2438101 ccttctggaa catcaaagtt cttcaagcgg agaagcggtg tattcccaat cagctcggta 2438161 atgtccgtaa tcactgtcat atatgtcctc ctccttaata gaggttgttt ttagagaaaa 2438221 acggaggaga acgttctccc cgttttaatg aattcgtttg atcaccttta acacaagctc 2438281 tgttgaatga acagccgcct gctctaaaaa ttggtcaaat gaaacatgtg attctttgcc 2438341 tgcgatatct gataacgctc tgatgacgac aaacggcgtt ttaaattgat ggcatacttg 2438401 agccactgcc gcagcctcca tttcaaccgc gtacagatca gaaaatctcg cacgcacctc 2438461 ttcaacccgc ttcggatcgt tcatgaaaga atcgcctgtt gcaatcgttc cttttgcaac 2438521 ctgaatgccg tcgagttcag ataccgcttc ttcagtgatg ctgatcagct tttcatccgc 2438581 cgcataagca gccggaagac ccggcacttg gccgtattca tagtcaaaag ccgttacgtc 2438641 tacatcatgg tggcgaacgt cagtggaaat gacgacatcc cctacattca atgtatgatg 2438701 aaatccgccg gctgagcctg tgttaatgac ataatcaggc ttgtaacggt caagcagaag 2438761 cgtcgtgctg atagcagcat ttacttttcc aattcctgat tttaaaagaa tcacttcagt 2438821 tccttcatat tcgcctgttg taaattcaca gtgtgcgatc gtttctgttt ttgcattttc 2438881 aagtttgttt cttaagatgg taacttcctc ttccattgct ccgatgactg ctagtctcat 2438941 ctattcacat tcccttcact ttaccgtttg atcgcctcca ttatccacac gaagtcgttt 2439001 tgctgagtga atcggactgc aaaaccttca gctgtaaaca tttctttcaa cgcatccaat 2439061 gtaggataat gctctgtctc taaatcattt gcaagctgat aaaagccttg agaacgggct 2439121 ttatcgatag cctgttgata cgcttgcgca ttttcaaaga cggtatcggc aaacactatt 2439181 ttatcatgca agtgaaggta tttgccatat tgctttatgg cagcccgctt ttcttcgtca 2439241 gtcaaatgat gaaaagcata tgaactgaca atcgtatcag cctgaaatgg cggctcaggg 2439301 aatgtcagga agtctccatc aacgatttcc gtcctgcctg agagcttgtc agaagccagt 2439361 ttacgcattg ctggagaagg ttcgattcca aatacagttt tgcctgcatc gagcagctta 2439421 gctgtcaaat tcccggtccc cgggccaaat tctaacacat gcgttccaga ttttctgacg 2439481 atggcatcaa ggatatgatc gtagcctctg aacgcttctt tatactgaat atctaaacct 2439541 tgtactgttt gatcataagt tgctgcccaa tcttcaaaga gagggataaa ttcacggccc 2439601 atatttgtca cactccatat ttaataattc ctataagtat actatggatt aatgatggaa 2439661 cagttcctat aataccacat attctgaaaa gcaggtacta aaacactttg tgtattttat 2439721 gccatctcat attgcgcatt gaccgcaaaa aagcttatac ttcatatgac ttgtgaaagc 2439781 tggagggtca agacatgaat tttcaattag atctgattaa agacaaagtg gaattttttg 2439841 aagcggcttc attgcaggag cttgaaaaga aaatcaatac acaaattgaa aacaataaag 2439901 ccatcatgct ccgggtgaaa tctgtttcac accaaactct tgtggcagaa ggaagaatat 2439961 tgtacagcgc ggtggttcat ttctcagctg aagcctaaaa caaaagcagc cggttttaac 2440021 ccggctgctt ttgtttattt tagcttttct acttttgtcg gcttccagcc tttttcatcg 2440081 acccatgtaa tcgtgacttg atatttattc ccagtcgcct tgtccaaaat cttgcctttg 2440141 gcatcctgag ggctgccgtt atttccaagc cagagcaccg tcatgttatc tgttgagaca 2440201 ccagttgcgt acgaaatggc tttcagcatc tcagcccagt cttgtgagct tgaatcataa 2440261 gtagcggcat gctcgccagt ctgctcagtt ccgactgctt tccagtcagg attttcatac 2440321 gttttttcca catcgctcga tgagccgcct tctgttactt ttgcatcttt aagcccgtca 2440381 ccggctgaat ctgagcttga atctgaatca gagtcatctt ttttagaaga agaatcatct 2440441 tttttggaat cagagtcaga agacttctca gaatcctttt cgctgtcaga tgtatctttc 2440501 ttgctgtctt ttatatcctc atccgatttc ttttccgtct ttcctgaagc cggagattcc 2440561 tgtttttgcg ccgtttcaga atccttgctg acatctttgc tagaaggact gttaatgaag 2440621 agattcgctg ctactacgac aattagtatg gatacgattg cgattaaaat gttaagcact 2440681 aaattggctt ttctgcgttt atcacgattt tcataacgag attgattatt gctcaataat 2440741 tctgcactcc tttatccctc ttggctcagc atatatttta acatgtgctg agaagttgtt 2440801 ctatttctga ttgatttcaa tttcgtgtac ttttttaaca atatcataaa acaccgaatt 2440861 tgtcagagcc ttatctcccg gtgtatccat gtgtaaaaca actagagcgt atttcggctt 2440921 atccgcggga aaatatccgg caaaccattt ttcgtagagc gtttccttct cttttgaaag 2440981 cttgcctgtc tgggctgtgc ccgacttccc tgctacagta tacggaagat cttgaaacct 2441041 tctgcccgtt ccggaaggag attctactac ccgccgcagt attttttgaa gctgctgtga 2441101 cgtatatttg tctatcgttt cccctttgag cttctgatct ttaaacgtaa cgagcgttgt 2441161 gccgttctta tactcaattt gttcggcaat tttcacctgc cgtttttctc cgccgcgggc 2441221 gattgtcgcc atcatattgg ctacctccag cggcgttacc tttacatttt tctgcccgat 2441281 tgctgtttgc gcaatggctt ttttgactga tttgtctttt tcatcccccc aaatcacgcc 2441341 gcttttttcg ttatacagct ggcggaaatc ggtttcgtgg tacagttttc cctcccagcc 2441401 tgcccgatca gtgagagcca gcttctcgga catatcttca ataaccgagc tgtctttttt 2441461 cattaattgt tctgcaagac tcgtaaatgt gtaattacag ctttgggcaa aactttcatc 2441521 aaaagacaag gtgcctttgt cgtcccccgg ttccccgtac aggtttaaat tgcaattaaa 2441581 ggtttgacta ggcttcacca tattattttc gattgcagct gcggcaatga ctgttttaaa 2441641 aactgatccg ggatagattg gcgtcagcat ataattttga agtgtgtttt gccgggacac 2441701 gtctgcatct ggtttgctta caattcccag aacactgcta ttttcgatgt ccagcagcac 2441761 agctcctccc tttttcagcc cctgttcatc caatacctcc tccatcgctt tttgaatgct 2441821 ttgatcgatc gttgttttga tctggagcgg ataaaatgta ttggcttcag ctgtatattt 2441881 gacgtccatg ccaaacaaag ggtttccttt tccgtccaca tgatataaaa gctttgtgtc 2441941 ttgttccgga agcaaaaact cgtcaaatgt ccgttctaaa ccggttgttc cgatttctgt 2442001 tgtaatcgga aggctctcct tgtcaggata tttcttgcga agcagcgccg gatcttggtt 2442061 cgtgctccct atcgtatgtg aagcaaggct gggcttgtct tcattctcca tatatacgcc 2442121 gtaaatgccg ggatatttca aagaattgat ttttgtgata gattgttttg aaagtgtttt 2442181 gattttcttt tgctgcaaaa tgaccggttt ttttgcctga cctagtgtct ggcgcaaatc 2442241 atcttcagac atgccgagga tgtccgcaac ttttttgatc ggccaatcct gcgtcagcag 2442301 aaaagggaac aaaacaaccg caggctcgct ttgtcctgtc agcgcccgcc cgtttcgatc 2442361 taaaaaagag cctcttccat ctgaaatgag cacttcctcc gtccgctgtt tcacactttc 2442421 ttgaatcaaa ttaattttct ttttagaaaa tgattctgtg aaaaacagct ggatttctgc 2442481 aagtctcagc agaagcagaa aaaatacaat caaaaaagcg atgactgcca gcttcattcg 2442541 tttcgatatc ttcataaaaa aacacctcac ccacattgtg gacgaggtgt ttcgctgcta 2442601 aacagatatt atgaaatttt cacaattttc acgagcattt ctccgcccgg tgtttgtact 2442661 gtgacttctt catctacttt tttgcccaag aggctttttg cgatcggtga atcgtttgag 2442721 attttccctt caaacgggtc agcttccgcg cttccgacga tcgtatatga ttcttcatca 2442781 ccgtcaggca gttcgacgaa agtgacggtt ttacccaaac cgacaacgtt agagccgccg 2442841 tcatcttcaa tgattttcgc attgcgaatc atattttcaa gagtcgtcac gcggccctct 2442901 acaaatgcct gctcttcttt cgctgaatcg tattcagagt tctcggaaag gtctccgaag 2442961 cttctcgcaa ttttgattcg ctctactact tcttttcgtt taaccgtttt caaatattct 2443021 aattcttgtt caagtttttg ttttccttct gcagtcatag gaaaaacttt ctcttgtgcc 2443081 atgtcccttc actccttctg gttgtccctc aacatcttcg attatgtatg agagcataaa 2443141 ctaaaaaata caagaatgag aacacagggc agtcctcgtt cttctctccc atataggtac 2443201 tgtttatctt aaactgaatc gtgtcgttct gcaaatattt cgcgtttata aacagggaaa 2443261 gaagggaatt cgcacattcc cttcctgcct atacataata tggtcagagt tatttatgtc 2443321 tatgctatgg tattacaaaa tcgcgttttg ttcaagaatg gtttgaattt ttgtgaccat 2443381 cagatcaatt gcgacgtgat tctgaccgcc ttccgggata ataatatcag cgtatcgttt 2443441 cgtcggctcg acgaattggt tatgcatcgg acggaccact gacacatatt gttcaatgac 2443501 agaatcaata gagcgtccgc gctcattaat atctctcata atccgtctga tgatacgcaa 2443561 gtcagcgtcc gtatcaacat aaagcttgat atccatcaga tcacgaagcc ttttgtcttc 2443621 aagaacaaga atgccttcaa ggataataac atcctttggc tctacgtgaa ccgtttcttc 2443681 tgaacgtgtg tgaagcttat agtcataaat cggcttttca atcgggcggt aattcaatag 2443741 atcttgaata tgctcgatta aatagtcatt atcaaacgca agcggatgat catagtttgt 2443801 gttcagcctt tcttcaaacg gaagatggct ttggtcttta taataaaggt cctgctggat 2443861 cattaaaatt gagtgtcctt taaactgttc ataaatggac cgtgtgacac tcgtttttcc 2443921 tgaaccggaa cctcctgcga ttccaatgac tactggattc ttacccatgg gctgttactt 2443981 cccctttctc atcatgttgc tcggataaat ctttttgtct agtttgaatt tgacaatttg 2444041 caggggatgg cgggcagcat ctagctcatt tccgtcttcg tcccaaatgg tttcaatcgt 2444101 atgtgtaaag ttttcgattt ctggaccgaa aaattccact tcgtcgcctt ttttgaagaa 2444161 attgcgctgc tgaagcgtga ccatttgtgt atcttcatca taattcagca ctaagccgac 2444221 aaaatcatat gtcgttttct tggcgtgttc gccgaacatt tgctcttcat agcctggcgt 2444281 tccttcaaag aaagctgtcg cagtgtccct gttggcgcac ttatcaagct cttcaagcca 2444341 ttctttttga atcacaaagt tttctggatc agcgcaataa gcatcgatta ctttgcggta 2444401 tacgctgaca acagttgcta catagtgaat ggatttcatg cggccttcaa tctttaagct 2444461 gtcgatcccc atttcaatca tttttggaat ggattcaatc agcttcaaat ctttcgggct 2444521 catcgcaaat ggtgcatctt cttcaccata caaagcaacg gcgttggcac cgtctgtttg 2444581 gtagagatca taatcccagc ggcatgactg gcagcagcct ccgcggttgg aatcccgcgc 2444641 tgtcatgtga ttgctcagca cgcagcggcc ggaatatgca atacacattg cgccatgaat 2444701 gaaggattcg atttcgatat ctaccttttc tttcatttct ctgatttcaa gagcgctagt 2444761 ttcacgtgcc agcacgacgc ggtcgagacc ttcttccttc cagaactgga cagccttcca 2444821 gtttgaaaga gactgctgtg tgctcaagtg aacctcaaca ttcggcgcca ctctgcggca 2444881 tgtttcaata ataagcggat ctgccacaat aataccggca acgttggcgt ctccaagcgc 2444941 ttttaaatag tcttcaagcc cgtccatgtt ttcattatga gcgaaaatat tcgttgttac 2445001 gtagatcttc gcgccatatt tctttgcgaa ttcaacgcct tctgcaattt cttcgatcgt 2445061 aaagttatcg gcattcgagc gaagcccgta ttcctgtccc ccgataaaga ccgcgtccgc 2445121 tccgtaatga acagcgattt tcagcttttc aagattaccc gcaggtgcga gaagctccgg 2445181 ctttttcgta atcacacgct ttccattaac gattgtggat attttatcat ttacggcagt 2445241 catagcttaa cctccttttg attaataaac cgtttccttg aagaagaatc cggtatcaat 2445301 ttttctgttt actggctgga tgctttcaat gcgttcgatc cagtcttctt ttttcgcttc 2445361 gtattcgtca cggttttcca cgcacaaatc aattgcttct ctgtacattt tggtgacttc 2445421 tattaggtat tcaggcattt tcaaaacacc atcgattttg aaagaatcaa ttccggcatc 2445481 tatcaattcc tcgagctcat caatgatgca cacatcgttc gggctcatga tgtgagtgcc 2445541 gttttcatct tcgaaaatcg gatatttatt atcgcgttct ttatcgtgta aaaacatgcc 2445601 tgattctttt ttctttcttt caatgtccat gactttgccc tgatattcaa aatagtttcc 2445661 aatcaaagaa cgcttcgatt ggaacatgca cgtcattcca tgcacctgga tttcaatttc 2445721 gacttcagca ttttctttaa tctcaacaat gctgtccatg tttaattctc tggcaagcac 2445781 agaacgcgcc gcacccttgc gtccccagta gttgcatgta taatagttgg tgcctgtcgt 2445841 ttctgtgctc caatgaagct tcagatcagg cgcagattca cgggcagcca tcagcacggc 2445901 aggatcgccg aataccgctg catcgacacc ggcttctgct aagaaagcca gatattcgcc 2445961 aagctcaccc actttatcat tatggaaaat tgcatttaca gcaacgtata cttttgcccc 2446021 ttctttgtga gcaatctcta cggcttttgt tacatcttca cgagaaaatt ctccggctaa 2446081 tctcaagccg tatctctgtt ccccaactaa aaacgcagtt gccccagcct gtatgagcgg 2446141 caaaatgtcc gctgtactcg tcggcgtcac taagagctct ggttttttca tgacgttcac 2446201 ctcttctttt tactaatcgc aagtccgtcc ccgacaggaa taatcgcagt ttgataatcc 2446261 ggatgattca tcagccaatg attatattca tcaattttgg ctacaagcct gcgccttctc 2446321 ttcggttcta ttttgctgta atcctctgcc accagacctt taaacagcac gttgtctgtt 2446381 ataatcaccc cgtccggtga aagcatcggt tcatataaat gaaaaaagtt ttgatactga 2446441 ccttttgcag cgtcaataaa aatgacatcg taaggcgcgg ttacatgaac ggcgtcggct 2446501 aattcaagcg catctccgta aaaaacatga atccggtcat caagctgaaa ttccttgata 2446561 ttgtttaccg cttcttcatg ccgtttctca ttgcgttcaa ttgtatatat ttcagcagac 2446621 ggcagttcca gagccattcg aatggctgaa taaccaatgg ccgttccgat ttctagtatt 2446681 tttttcggct gtttcacaga caaaatttga agcagcacct ccatgcccgc tttttccata 2446741 atcgggacat gatgttcttc tgcatatgct tcaagtctct tcacgttatc cggccgaggc 2446801 tttaataatg cttctatata gtcatttatt tgttcatacc ggtcagtcac tacaaacagc 2446861 ctcccgttct aaaaaggagt gccccagtct tatgcgcagg acactctctg aatacatcat 2446921 gatacatcgg taaacaaccc gatatatttt atcataaaac cttgcggaaa gcgaacaaaa 2446981 ggagagcttt ttgctctcct tttatttctc attttttgag gaaatgtatt tttcttttgc 2447041 tttattatgc tcttttagcg tttttgtaaa tacgacctca ccatttgatt tggccaagaa 2447101 atacagatag tccgttttat ccggatgcag cgctgcttcc catgatgaca tgccggcatt 2447161 ggcaatcggc cctggcgtca gccctgtgtt tttatacgta ttgtatggtg aatcgatttc 2447221 cagatcctta taaagaaccc gatctttatg cttgcctgcc gcgtacagga cggtcggatc 2447281 tgtttggagc ggcattttct ttttcaggcg gttataaaag acgctcgcaa ttttatggcg 2447341 gtcggctttt tcagtcgctt cttcttctat caaagaagcc attgtcagca gcttatgcac 2447401 agaaactttg tttttcttca tttctgattt atatgtttcc acataagaat ttgtctgctt 2447461 aatcattgcc ttgataatgt cttcaagtga tgtgtccgga tcgttaaaag ggtatgtagc 2447521 cgggaatagg tacccttcaa gcgggtgctt aatgttttta ttgaaaacat catttgtcac 2447581 agtgtccggg aattctttct tcagctgatt gataaatgtt tcatcgtcca gcttcgctat 2447641 gacttgtttt ttagagtatt ttgtttcatc agcaatagca gccgcgattt gggtcagctg 2447701 tgctccctca gtcactgtga tttgaaaagc gtaacctgta gccccgcttg tcagcttctg 2447761 aataatggca tctaaatcca tacctttatt cagatggtag aatccggcct gaaacccgga 2447821 agcaccttta tatttcacat agtactgaaa cgccttctcg ctttttatga catcattttt 2447881 ctttaatatc gatgcgatgg ctgaaacaga cgaaccgctc ggaatgttaa tattaactgt 2447941 cgttttactg tctttttcaa caggttcaag caatgatttc ccatataaaa atgccccgcc 2448001 aatgatgaga aacagcacaa caatggaaga cagtatgatt ctttttttat taaaaaacga 2448061 ttttttttgc tgattgatat acattaggtc tcctcccatc agctcttata ctacatgatt 2448121 cattgtattt cggcaattta ttacaaaaag aggcctgcat aaagcagaaa aaagccggag 2448181 cagtatagct ccggctttgg tttggcgcga tgttttactc ttcgtcttcg tccgctaaga 2448241 atgtgtttag tgtttcttcg atcatatccc attcttcgtc agtttcaatc gggaatagct 2448301 caccgttttc accgtcttcg tttggcgtga agctggaagc aagaatttct acttcttcgt 2448361 catcttttga ttcgattgga tagtacaaga cataagattt gccaaactct tcattttcaa 2448421 atgtaaacag cacttcacaa agctgttcat ttccttgatc gtcaacaatt gtaatatttt 2448481 tttcgccgtg ttccattttc ttcacctctg gctttaattt aagctgtcaa gatatccttg 2448541 taaaatcata acagccgcca ttttatcaat gacttttttt cgtttttgcc tgctgacgtc 2448601 agctgcaatc agcatttttt cagccgccat tgtggtaaga cgctcgtccc acagcacaac 2448661 aggaacattg tacgttgttt caagcacttt cgcaaatgtt tggctggctt cgcctctcgg 2448721 gccgactgtt ccgttcatgt tcttaggaaa gccgagcacg attttatcta tagtatagtc 2448781 ctttatcagt tcagataaac gggataaacc ataatcgcct tctgcttcat ttatctttat 2448841 ggtctcaatg ccttgagcag tccagcccat ttcatcgctc agagctacac cgagtgtttt 2448901 ggttcctaaa tcgagtccta atattctcat tctttattta cgcctcttta tgctgttcta 2448961 aataagactt taccaattcc tcgattaatt cgtctctttc aagtttgcga attaaattgc 2449021 gagcgtcacg atgcctagga atataagcgg gatcacctga cagcaagtat ccgacaatct 2449081 ggttgattgg attgtagccc ttttcctgaa gcgcgtcata cactgtaatc agcacctcat 2449141 ttacgttagt ctcagcagaa tcatcggaga aattaaattt catcgtttta tcaaacgagc 2449201 tcaccgtttt gcacctcttt cccaaattcg caggcaaagt tcagcctggg gtcctaatct 2449261 taccatcatt ctacactaca tgggcgaatt ataaaacgga tttcacccaa tcttctacag 2449321 aagccaaagc ttcttctaat ttttccggct gtttaccgcc tgcctgcgcc atgtccggac 2449381 ggcctccgcc gcctccgccg caaacttccg cagcttgttt aaccagcttg ccggcgtgaa 2449441 gtcctttctc aatgaggtcc tttgtgactc cggcagagat attaacttta tcgttttgta 2449501 ccgcaccaag cacgatcacc gcagagccaa gctttgcttt gagttcatcg accatagtgc 2449561 ggagatgatt catgtctttt gcatttactt ttgccgcaag cacgtttacg ccgtcaactt 2449621 cttttacttt cgacaggatt gctcctgctt ccacgttgcc tagttttgca agaagagatt 2449681 cattttctct ttgtgcatcc ttcagttcag cctgcagagc cgcgacccgt ttcggcactt 2449741 ctttgatatt tgttttcagc tcgtcagcgg tctgcttcaa tacagaaatc tggctgttca 2449801 tttcgacgta agcgccttgt cccgttacag cttcaatccg tcttgtgcct gctccgattc 2449861 cggattcaga aacgatttta aacaagccga tttctgctgt atttctgacg tggcagccgc 2449921 cgcacagctc taagctgtaa tctccaactt gaacgacacg gacaatatcg ccatattttt 2449981 cgccgaacag tgccatcgca cccatttctt ttgcttcagc gatcggtttc aaatcaatgc 2450041 tgaccgggat gctcgcccag atcttttcgt ttacgattct ttcaatttgt tcgagctctt 2450101 cttttgtcac ttggccaaag tgcgagaagt caaaacgaag gcggttttcc gttacaagag 2450161 agcccgcctg attgacatga gttccaagaa catcttttag agcctgatgc aataaatgcg 2450221 ttgccgtgtg gtttttaatg acgccgcttc tcatatggtc ttcaacttca gccgtaacat 2450281 gcaggccttt ttgaacagta ccgctctcca caacaccttc atgcacatgc tggccgttcg 2450341 gcgctttttg aacatcttta attcttacaa ctgcctgctc gcttcggaga tagcctttgt 2450401 cgccgatttg gccgccgctt tctgcataga acggtgtttc atcaagaatg atttgaacgc 2450461 tttctccttc atgagcctct tcgattaatt ggccgtcctg aagaagcaca atgatattgg 2450521 catcagcttt ggtttgagag tagccgacaa atgtgctttc aactgtcacg tcgcgcagtg 2450581 cgccgccctg cacctgcatg ctgccgacat cctggcgggc gtttcttgcc cgttcacgct 2450641 gctggttcat ttcctcctca aagccctcat ggtcaaccgt catgttctcg tcttctgcgt 2450701 attcttcagt caattcaacc gggaatccat acgtatcata cagtttaaac acatcagcac 2450761 ctgagataac gctgctgccc ttgtcttttt cttttttgat catttctgac aggatcgcaa 2450821 gcccttcatt aagggtctca tggaagcgtt cttcctcggt tttaatgact tttgcgatga 2450881 aatccgcttt ctctttcact tcaggataga aatcagccat gatttctgcg acaaccggca 2450941 ctaaatcaaa catgaacgga cgatggatgt tgatcgtttt ggcataacgc acggcacggc 2451001 gtaataagcg tcttaataca tagccgcggc cttcatttga cggcagcgca ccgtcactga 2451061 cagcaaaggc aaccgttctg atatggtcag caatcacttt aaacgcagtg tctttcacat 2451121 tgtctttgcc atatgtttca ccagaaatcg attctgttgc tttaatgatc ggaacaaaca 2451181 aatcggtgtc aaagtttgtc ggaacattct ggatgacaga caccattctt tcaagaccca 2451241 tgcctgtatc aatatttttc tttggaagcg gtgtgtacgt gccgtcaggg ttatggttga 2451301 actctgagaa cacaaggttc catacttcca ggtaacggtc gttttccccg cctgggtaaa 2451361 gctccggatc ttctggatca ttaccgtatg cttcaccgcg gtcgtaaaag atttccgtat 2451421 tcggtccgct cggcccttca ccgatatccc agaagttccc ttccagacgg ataattcttt 2451481 cttcaggaat accgattttt ttcgcccaaa actcatatgc ctcttcatct tcaggatgaa 2451541 ccgtaacaga gagaagctct ttgtcgaagc caatccactt gtcgctcgtt aaaaactccc 2451601 aagcccatgt aatggcttct tctttgaaat aatcgccgat ggaaaagttt ccgagcattt 2451661 caaagaaagt gtgatggcgc gcagttttac ctacattttc tatatcgttt gttctgatcg 2451721 ctttttgagc gtttacgatt cttggatttt ccggcacgac acggccgtca aaatattttt 2451781 tcagcgtcgc aacaccgctg ttgatccaaa gcagtgaagg atcctcatga ggcactaatg 2451841 acgcgcttgg ctctaccgca tgtccttttt ctttaaagaa atccaaaaac atttgacgca 2451901 cttccgcaga agttaagtgt ttcattgtat ttcctcctct ataaaaatcg aaattctctt 2451961 cagtgacagc aaaaaagccc tccccctatg caaaccaacg tttacacagg gacgagagct 2452021 gtctcgcggt accaccctga ttacgggcat tcatgcgccc gtcaccttta accctgtaac 2452081 gcaggataag cggcagtgat taactgcact caggattagc ttcctccgat cttctgataa 2452141 agctcctttc agcttatgga gcttctctct ttaacagggc ttcggcgtac tcagatccgt 2452201 cactcgagat tcgtatgtat tctacgagaa attatagaca agcggcacgc cgatgtcaat 2452261 gctccgtcct catccgcaaa aaatggatca tcattacttt taaaacagcc gtcgcaggaa 2452321 cagccagaat catcccgacg atacccgcaa gctcccctcc ggcaaggagt gcaagcatga 2452381 taacgaccgg atgcatttta aggcttctgc cgacaatgaa cggactgagg atatttcctt 2452441 ccataaactg cagaataaac accgtaatca ccacaacaag aaccgccttg actgagatcg 2452501 tcatcgcaat taacaacgca ggaacagctc cgatgaaagg gccaaaatac gggatgacat 2452561 tcgttacccc agagataagg ccaagtatca gcggatacgg aagcccaaat acccagaacg 2452621 aaatgcctgc aatcacgcca agaatcaagc agaccaaaag ctggccgcgg atataatcgc 2452681 caagcgaatc atccacatcc cgcaaaaagg cgctgccccg ctttctccac gacttcggag 2452741 tcaagtacca tactgtcttt ttcattaact caatgtcctt caccatataa aacacgagaa 2452801 aagggattgt tgcagcaatt aagaagtaat caagcacatt gcggatcccg ctgatcgcac 2452861 cctcgatcgt tcccgcaaaa aacgcctccg tctggcggat cattttatct atacggtgat 2452921 gcataccatc aggccagtca tccgtatggt tatgcacatg aagaagaagc ccgttatacg 2452981 tttcggcaaa catgggtata ttttctgaca aatccgtcag ctgcacgatt aaaacaggca 2453041 cccctttata caacgcccag ccaatcccgc caaaaaaaag aacataaatg accaagatgc 2453101 tcaaagtcct aggcaatcct ttgccatgca gccattctgt gaccggaagc aataaataag 2453161 atataaaaat agaaatgatc aagggaataa agatcgtttt tatgacgagc caaaagggtg 2453221 accataacat atcaagcata aaaaagacat agactgttaa cagaaccagc aaacaaatag 2453281 ccacccacaa caaaagctgc accggttttt ggagcatctg ctttcacctc acctatatct 2453341 tttgaggttt acaaggaatt attctttatg tttctttagt cagtcagaag tcatggacat 2453401 tttttcactt ttaattttca gaaaagtttg atcatttact ttttggtcaa attttctgat 2453461 aggaggattg cgatgatcac atttcaaaat gtaaacaagc attacggaga ttttcacgtg 2453521 ttaaaacaaa ttaatcttca aatcgaaaaa ggtgaagtcg ttgttatcat cggcccatcc 2453581 ggttccggta aaagcacatt gctcagatgc atcaacagac ttgagtcgat caatgaggga 2453641 gtgcttacag taaacggcac cgccattaac gacagaaaaa ctgatatcaa tcaagtgcgg 2453701 caaaatatcg ggatggtgtt tcagcacttt catttatatc cgcataaaac agtgctgcag 2453761 aacatcatgc tggctccggt aaaagtgctt agacaatcac ctgaacaagc aaaggaaacg 2453821 gcgcggtact atcttgaaaa agtcggcatc ccagacaagg ctgacgccta tccttcccag 2453881 ctttccggcg ggcagcagca gcgtgttgcc atcgcaagag gactggcgat gaagccggag 2453941 gtcatgctgt ttgacgagcc gacatcagca cttgatcctg aaatgatcgg tgaggtgcta 2454001 gatgtcatga aaacactcgc caaagaaggc atgacaatgg ttgtcgtgac acacgaaatg 2454061 gggtttgcca aagaagttgc cgaccggatt gtcttcattg acgaaggaaa aattttagaa 2454121 gaagcagtgc cggctgaatt ttacgcgaac ccgaaggaag aacgggcccg cttattctta 2454181 agccgtattt taaatcatta aaacagaaat gggggagctt gtatgaaaaa gattttttct 2454241 ttagcattga tttctttatt cgctgtcatc ttgcttgccg cttgcggcag caagggatca 2454301 aacggagaag cctcaaagga gagcaaaaaa gatacgctag ccgccattaa agacaatgac 2454361 aaaattgtct tcggcgtaaa aacggacact cgactgttcg gtcttaaaaa tccaagctca 2454421 ggtgagattg agggttttga tattgatatt gctaaacaaa tcgctaaaga cattttaggt 2454481 gatgagaaaa aagctcaatt taaagaggtc acctcaaaaa caaggattcc tatgctgcaa 2454541 aacggggata tcgacgccat tgtcgccaca atgacgatca ctgaagaacg aaaaaaggaa 2454601 gttgactttt ctgatgtcta tttcgaggcc gggcaatcgc ttctcgtgaa aaaaggcagc 2454661 aaaatcaaga gtgtcgagaa tcttggcaaa ggctcaaaag ttcttgcagt aaaaggctcc 2454721 acctcctctc aaaacattcg tgaaaaggcg cctgaagcat ctgttttaga atttgaaaac 2454781 tacgcagaag cctttacagc ccttaaatcg gggcaaggcg atgccctcac cacagataat 2454841 gcaattttat atggaatggc tgatgaaaat aaaaattatc aattaacagg aaagcctttt 2454901 acagatgagc cttacgggat cgccgtgaaa aaagggcaat ctgctctcgc gaaagaaatc 2454961 aacgcttcac ttaaaaagat gaagtcggat ggcagatacg atgaaattta taaaaaatgg 2455021 atcaaagaag acccagctga ataacaacca tcccgggatg agcaggcgat gctcatccca 2455081 atttgataag gagtgaatag gcagatgaat gtgtcaattc ttttcgataa cttcagcatg 2455141 tatatggacg gtttttacca taccttgctc gcaagtgtta tcgcgctggc cggcagtttt 2455201 gtcctcggcg ttgctgtagc ggttatgaga ataacagtct ttaagccgct gcaatggctc 2455261 gggaccgcat atgtagaatt catccgcaac atccctcttc ttttaattac ctttgttttc 2455321 tatttcggac ttccaaacgc aggcctgagg cttgacggtt ttcaagcggg aacggttgct 2455381 ctcaccattt atacctctgc gtttatcgct gaagccatca gagcaggcat ccagtctgtt 2455441 tcaaaagggc agatggaagc ggcacgctcg tcaggcttta cctacagcca agccatgctc 2455501 catatcattt tgccgcaggc aatcaaaatc gtcattccgc ctttaggcaa tcaattttta 2455561 aacttagtca aaaactcttc gattcttggg gttgtggccg gattggatct tatgtaccaa 2455621 gccgatttag tttcgtcgag cacactcgtt gtatttgatg tttatatttt tgtggcgctt 2455681 ttttacttag tgctgacgat tccgcttagc atcggtgtta actatctgga aaaacggctg 2455741 gaaaaaagct attgataagg agtgagttac attggatttc atcggtgctt attcacagga 2455801 gcatttagcg tttttatggg atggctttct cgtcaccttg tacgttgctt tcatctccat 2455861 cattctgagc tttttcttcg gtttaatcgc aggcaccctg cgttatgcga aagttcccgt 2455921 tctttctcaa ttgattgcag ttctcgttga aacgatcaga aacctcccct tgctgttaat 2455981 tattttcttt acgttttttg cccttccgga aattgggatt aagcttgaaa ttacagctgc 2456041 tgcaattaca gcactaacga tttttgaatc cgctatgcta tctgaaatta tccgaagcgg 2456101 actgaaatca attgacaaag gacaaattga agcggcgcgc tcctccgggc tgagctatac 2456161 acagaccctg ttctttatcg ttatgccgca agcgcttcgc cgcatggttc cgcccatcgt 2456221 aagccagttt atttctttat taaaagatac atcgctcgct gttgtgatcg ccctgcctga 2456281 actgattcac aacgcgcaaa ttattaacgg ccaaagcgct gacggcagtt attttttccc 2456341 gatcttttta cttgcggccc ttatgtattt cgcagtcaac tacagccttt cactcgcagc 2456401 aagacgcctc gaggtccggc aaacatagaa aaggatactc tttggagagt atcctttttg 2456461 cattaaaaca ttttcgtaat tcttcttctc atccgcttca tgcttcgatt attcagcatg 2456521 tcagattgag tcgccattcg gtacacgaga gctccggctc ccattgccaa aagagaagtc 2456581 atcgtccgat tcatcctgcg catctccttt catgattaaa aattgatgct gcgttcatcc 2456641 tcagaaaaca aatcatccaa gctgcttaac gttccgtctt cttccacctg atgagttgca 2456701 atcttccctt tcgccactgt cagttcaata aaacagcccc agcaataata ttggttcacg 2456761 ccgattttgc cgatatcctt acttttgcaa ttcgggcata taagcatacc tcacacctct 2456821 atccgttcag aacgatctcg tctttccgca cctcgacaag cgaatccgct ctttggatct 2456881 ggcgcttgct tcccgccagg tcagaaaaga aaccgtccga gagttcatat gctacgatta 2456941 tgcccctgtc caaacaaaag tatacatctt ccagcatccc caatatatcc ccctcttgcg 2457001 atttcacaag cttcatcttc atctgctcgt atgtgaagca tgatttcgga agaggcaaaa 2457061 gctgttctga actgaccgaa gccaatatgc ggtcatcaaa aatggaagag atatcacacg 2457121 cccgtaatag cgcatgatga tgatgcaaaa agcgtttttg tgcaagaata aacccaagac 2457181 aatctccttt cagagaaaaa caaatatcgg aaattgtccc gagataacta gaagttcgtt 2457241 ctgagtatac tgggaatcct tctacttcat ggcatgttct caaagtgtga tcaaccacct 2457301 tttgttgaac aggcttaggt tttgctttgc gccttagact catacgatga aatcaattcc 2457361 actgcaaatg aaaaaaaact cccgcttgca cgggagcatt ttattgctgt tcttctttca 2457421 taaaatcgaa tggtgtaatg ccttccatgc caatgttggc gtcgtgtacg ctgaacggga 2457481 gctctttttg caaagcttca agctcggcat ccatttcctc aacctgtacg gacagcctgt 2457541 ttttcaagga ggtctgtctg acagttgcat cattattttt cacgccccac tccagcgcct 2457601 cctcttcccc gcataaaatg agaaatttct tcgctcttgt aatcgcggta taaagaaggt 2457661 ttcttctgag cattctataa tagcctttca caacaggcaa aaccacaatc ggaaattcac 2457721 ttccctgcga tttatgaata gaacagcaat acgcatgggt aaattgatta aaatcttttt 2457781 tcgtaaatgt catttcattg ccgtcaaaag aaacgacggc catgtcttct ttttctgtat 2457841 tttcctttgc ataaaatatc gacgtgattt cgccaatatc tccgttgaac acattgtttt 2457901 ccggctgatt gacaagctgc aaaattttat ctccggttct gtagacaaca tccccgaact 2457961 tcaattctct ccgtttttct ttaggaggat ttaaaatgtc ctgcagcatc acattcaatt 2458021 cattaatgcc ggcttttcct ctgtacatcg gagcgaggac ctgaatgtcc tttgctgtat 2458081 agcctttttt caatgcattg gcgacaacct tctcaactac ttctttgatt tgcgacccgc 2458141 cgcagcgaat aaaggaacgg tcctttgtcg gggcagtcaa attgttcggc agcaatccat 2458201 ttttcatctg gtgggcaagc tcgacgattg atgacccttc tgcctggcga tagatgtctg 2458261 tcagtctcac agtcggaatc acctgggatg ccagcaggtc tctgagcact tgtcccggac 2458321 cgacggaagg cagctggtct tcgtctccga caatgatgat ttgtatatga tcagggatcg 2458381 ccttgaacaa atgattcgcc agccatatat caagcatact ggcttcatcg ataattaaca 2458441 gcttcccttc gatcggctga tcctctgtat gagtaaagcc ttcagcgccg ttccagccaa 2458501 gcagcctgtg tatcgtaact gcagggagtc ccgttgattc actcatccgt tttgctgctc 2458561 tccctgtcgg agcggccaaa acaatcggaa aagcttcatc ctttttataa gctgacgggt 2458621 ctagtgacac accgtgaagc tctccgtaga gctcgacaat ccctctgatt accgtcgttt 2458681 ttcctgttcc cgggccgcct gttaaaagaa gcatcggcga ggaaagggct ttttgaatcg 2458741 cttccttctg gctgggggca tactgaacgt ccatccgttc ttccagttct cccaacgcga 2458801 gcaaaaactc tgattcggga aactggttct catattcggt ttggctagcg atatgtttca 2458861 cacgctttgc aacgttttgt tctgcgtaaa acagcgaagg aaaataacag cggccatctt 2458921 ctatgacaat gtctttattt tctccaaggg caataattgc gttagcggca tccatttctg 2458981 taatgcgctg cccttccctt gctgactggt ttaacagtga ttgagtgtcg atgatcagct 2459041 gttccgtttc tatgtacgtg tgcccctctg acagacaagt cgtttcaagc gtgtacaaaa 2459101 tagcagcttt tacccgctca ggatgattac ccgaaagacc cattctgctg cccagctcat 2459161 ccgcttttcc aaacccgatg ccttctacat ccttcacaag ctgataagga ttttcctgaa 2459221 tcttttcaag cgtctcggat tcataggctt gatagatttt catagacagc tgcgggccaa 2459281 agccaaactg attcaaggaa atcatgattt gctccagtcc ctgatgccgc tgcaatgcgc 2459341 cagccagcgt gtctgctttc ttttttgaga gtctgggaac atcataaagc actgaagcat 2459401 cagccaatat tttattaatg gcgctgtcgc ccagcttttt cacaatttct tcagctgttt 2459461 ttttgccgat cccctcgaat aaatcactcg ataaatattg aatgatgcct tccttagtcg 2459521 ttggaatctc ctttttgaaa tgctccgcct gaaattggag cccgaatttt ggatgggtta 2459581 cgatctttcc gtaaaacgtg taggtctctt cttcttgaag cgcagggaag tagcccgtca 2459641 cggatacggc tttatcttca atggcttcgg aggtctctgt gactttcact ttcagaaccg 2459701 tatataaatt ggtgtcatta tgatagatga ctgtgttgac tgtccctttt aaatagggct 2459761 cttcctccag tttaagctga tccggatgct gctgcacgag ctgtccctcc tcctgtgcct 2459821 gttatgatgg atcaatcagt tttttagcat gaagcgcaag catatgatct ggctggatat 2459881 cgattgcctt gtccagcatt tccagcgctt tttctcggtt ttctttataa gcataagtga 2459941 caccggcatt ataaaatgca tctgcatgcc ccgggtcttg ctctgtcaca gctgcgaatt 2460001 ggctgagcgc ttcgtccagc atgccctcgt tggctaagca catcccgaat tgaaaacgcg 2460061 cttccgtatc gttttcattc agttcgactg ctctttgtaa atatggcagt gcaagcttag 2460121 gctgttcgag cttgacaagt accgttccga gcatgtaaaa caggtcgccg ttttccatcc 2460181 ccgcacgtag cgctttttca aacatgtctt tcgcttcttt gtacatttct tttacaacat 2460241 agacatttcc tgctccataa taagcagtgg ctgcgctact gtctaattca agcgctttat 2460301 cataaaacgc aagcgcacgt tccagctcgt ttacggatga aagaaggttg gcaaaattga 2460361 tatacggaat cgcgtcttct ttattttctt caatcgcttt tgtaaatgcc tctgccgctt 2460421 tctcgtaatc gccttcctgc atcgcctcta taccgagttg attataatcc accgatcatc 2460481 ttcctttcat taaaaaaccc caactcagtg ttgaggtttt tcatctttta tacgtaccac 2460541 aattttgttc cgtctttgta cacatcatca attgtcccgc cgccaaggca ttcttcgccg 2460601 tcatagaaga caacggcttg tcccggcgtt acagcgcgga cttgttcatc aaagatgact 2460661 tccgcttcac cttcgccagt catgcgcact gttactttat gatcctcttg gcggtaacgg 2460721 aatttagccg tgcaggaaat ctcttcgccc ttcatgatat ccgaacgtac ccagctgata 2460781 tttgttgctg tgattttgtc ggaatataaa agcgggttat ggaacccttg atctacgtag 2460841 aggatgttct tttcaagatc tttgcctacc gcaaaccacg gctcgccgct tccgccgatg 2460901 ccaaggccgt gacgctgtcc gatcgtatag tacatcaacc cgtcgtggcg gccttttact 2460961 tcgccgtcca tcgtcatcat atcgcccggc tgtgcaggga gatattggct gagaaacgtt 2461021 ttgaagttgc gttcgccgat aaagcagatg cctgtactgt cttttttcgt cgctgttgca 2461081 agttctgctt ctttggcaat ttcacgcaca cggctttttt gaagttcgcc gatcgggaac 2461141 atgactttgc tcagcgtatc ttctgtcagc tgattcagga agtacgtttg atccttgttt 2461201 tcatcaatgc cgcgcagcat tctgactttt ccgccgcttc tgtctactct tgcatagtgg 2461261 ccagtcgcta aatagtcggc gccaagtgac aatgcatgct ccaaaaaggc cttgaattta 2461321 atttctttgt tgcacaatac atccgggttt ggtgttctgc ctgctttata ttcatcaagg 2461381 aagtattgaa ataccttctc ataatattgc ttttcaaagt ttacggcata atacggaatt 2461441 ccgatttggt tgcagacgcg gatcacatct tcataatcct ctgtcgccgt gcaaaaaccg 2461501 ttttcgtccg tatcatccca gtttttcata aagattccga ttacatcata gccctgttct 2461561 tttaacagca gggccgccac agatgagtct actccgccgg acatgccgac gacgactctt 2461621 gtatcctccg gccgtttttc catttcattc actccaatta ctacgccgcc ttattatgtc 2461681 agccgtttga caacgtcggc cacatgtttg gcagcagttt tcacttgctc agccgtattg 2461741 ccgaggccga agctgattcg aatagaggac gtcagccggt cactctcttc gccgaacata 2461801 gcagtcagaa catgtgacgg caggactgaa ccggccgtgc acgctgaacc gctggagaca 2461861 gcgacaccag ccatatcaag attaaccagc agcgcttcca ctgacacacc ggggaaataa 2461921 agattcagaa catgcggcag actatgctct ttgtccccgt tgacctcgaa tgccacacct 2461981 gcatctctaa gcgtgtcggc aaagattgct ttaaacgatt gatacttctc gtttttttcg 2462041 tcacgttctt cacttgacag cttgatcgct tctttcagcc cgacaatgcc tggaacattt 2462101 tccgttccgg cacggcgttt tctttcttgc tctcctccga ataaaagggg tgaaagcttc 2462161 acatctttac tagcatataa aaagcctgtc ccttttggcc cgttgagctt gtgcccggaa 2462221 acagacagaa ggtcaatatg gctgtttttc acatcaattg gcagcaaccc gaatgcctga 2462281 acagcatcgg tatgaaaata agctttgtgt tcctttaaca gctcaccgat ttcttcgatc 2462341 ggctgcactg ttccgacttc attatttcca tacatcactg tcacaaggat tgtatcatca 2462401 cgcagtgctt ctttcacctg ttttgcactg actcttccat tttggtcaac gtccagatac 2462461 gttatgtcaa atccgtctcc ctcaagtttt tcacatgtgt gaagcacggc gtgatgctca 2462521 atttttgttg tgatgatatg tctgccaaga tcttttcttg caagtgcggt tcccatgatc 2462581 gccaagttat cagcttccgt tcccccgctt gtaaaaatga tctcctgctc tgccgctccg 2462641 atttctgctg cgatctgcgc tcttgcttca tccacccatt ttcgagattc tctgccaaat 2462701 gaatgaatac tggagggatt accgaaactg ccggagaagt gcggtatcat ttgttccagc 2462761 acgcgctcat ccatcggaga cgttgcggca tgatctaaat aaatccgttc cattatgttt 2462821 acacctctga tctaaatata gaacatataa gcttcttgct ctccgtctgt atagctggca 2462881 agatcctcta atgttgtact gtctaaaacc tcttttacag catcccggat gcgaatccag 2462941 agctcacgct tggcaggctc ctcatcttcc agcacttcaa cagggctgat cggcccctca 2463001 agcacacgga taatatctcc cgcagtaatg gcatccggct cactgcctaa tacatatccg 2463061 ccatatgcgc ctctgatgct tttcactaaa ccggcatttc tgagcggcga taccagctgc 2463121 tccaaataat gctcggacaa attattcgtc tgtgcgatgc tttttaatga agtcgggcct 2463181 tcaccgtgct tttttgcaag ctcgatcata atggtgagcc cgtatcttcc cttagttgat 2463241 attttcaaca tgaacacctc tgttatttca tgattttcca catttataat ggtaatttct 2463301 atatgtttcg tccgtttatt atcttataga ccaactgtta ttataacata ccttcagcga 2463361 attttcattg aggcagaagg aaaggggcct ttaccctttt ctaatgtacg gttttccgtt 2463421 accctgtaat taagtaagga gagatgatag atgaagccat tggcatatcg gatgcgtccg 2463481 acaaaaatag aggatattat cggccagcag catctggtgg ctgaagataa aattattggc 2463541 agaatggtcc aggcaaaaca tttgtcatcc atgattttgt acgggccgcc cggaattgga 2463601 aaaacatcaa tcgcaacagc aatcgccggt tcaacaagta ttgcttttcg aaagctgaat 2463661 gctgtcatta acaataaaaa agatatggaa atcgtagctc aggaagccaa gatgtccggc 2463721 caagtgattt tgattctgga tgaagtccac aggctggata aaggaaaaca ggattttcta 2463781 ttaccctatt tagaaaacgg aatgatcatt ttgatcggag caacgacggc taacccgtat 2463841 catgccatta atccggcgat cagaagccgg acccagattt ttgagcttga accgttaaca 2463901 cctgaactga ttaaacaggc actggaacgt gcgctccatg atgagcatcg gggccttggc 2463961 acctattctg tatccattga tgatcaggcg atggagcatt ttgcccacgg atgcggagga 2464021 gatgtccgct ccgctttaaa tgcgcttgag cttgccgtgt tgtcaacgaa ggagtcagca 2464081 gacggtgaaa ttcacattac attagaaacc gcggaagaat gcttgcagaa aaaaagcttt 2464141 tctcacgata aagatggtga cgcgcattat gatgtactgt ccgcttttca aaaatcaatc 2464201 cgcggctctg atgccaacgc tgctcttcac tatttggcta gattaattga agccggtgat 2464261 ctggagagca tcgcaagacg attgcttgtt atcgcctatg aggatatcgg tttagcaagc 2464321 ccgcaagccg gccctagagt gctgaacgct attcagaccg ctgagcgagt cgggtttcct 2464381 gaagcgcgaa tcccgctggc caacgcagtt attgagcttt gcctctcacc gaaatcaaac 2464441 tctgccattc tggcaatcga tgaggccctg gcagatatca gagccggaaa aattggggat 2464501 gtcccgaagc atttaaaaga cgcgcattat aaaggagctc aggaattagg aagaggaatc 2464561 gactataaat acccgcacaa ttacgacaac ggttgggtcg aacaacaata cctccctgat 2464621 cctctgaaaa ataagcaata ctataagccg aaacagactg gaaagttcga atctgcctta 2464681 aagcaggtgt acgataaatt aatgaaaaga aaataaaaca aaaaaacagc cttgatcatc 2464741 aaggctgttt ttatgcatta tttatccttc acacgtttga tttcaatgtc tttcaaaaga 2464801 tccatgacaa catgtccgcc cataatcaaa cctgcaactg acggcacaaa agcattagag 2464861 gaaggcggca tttttgcttt acgtattttc gcttcgtcat tccccacttc ttttctgaca 2464921 tcttcccgaa taacaatcgg gctttcatca gagaaaatca cttgaacgcc ttttttgata 2464981 ccctccttgc gtaatttcgt acgaacgacc ttcgcaattg gatcagtgtg cgtttttgag 2465041 atatcagcga tttggaagcg tgtcggatcc gttttatttg cagcacccat gctggagatg 2465101 agcggaatat cccgttttag acattctttc attaaatgaa ttttataaca aatggtgtct 2465161 gacgcatcaa tgacatagtc aagaccatag tcaaaaaact gctcatacgt ttcctccgta 2465221 tagaacattt ttaacgcgat cacttcacac tccgggttaa tgtctgcgat ccgcgccttc 2465281 attaaatcaa ctttcggctg tccgacagtt gaaagcagcg cgtgaagctg acgatttaca 2465341 tttgtaatgt cgacatcatc tttgtcgaca agcagaatgc ggccgacgcc tgaccgcgcg 2465401 agagcttccg ccgcgaacga cccgactccc ccgactccaa gcacagcaac tgtgctgttt 2465461 ttcagcgttt caaggccttc ttttccgata gctaattcat tgcgtgaaaa ctggtgtaac 2465521 aagaacctca ctccacattc gtattctggt ttcatctata aaatggctga tccatgagca 2465581 gccgtttttt ctgcgcacaa aaaataaagt cccaatagtg ccgttgcagc tttcctttgt 2465641 tttgaacccg ctctcagcag gtgggtgccc tcttttaaat cttgtaagtc ctctttaccg 2465701 aatgaaaaga ggcatgtacg ccatttaaaa atgcgggctc ccaaatcaaa aaaatgttcg 2465761 gtcaaaacta ggtgtacaac taacacatca ggactttatt taacttgtca aaatcatatc 2465821 acagacgatt ttgattttca agaatcgaac tgcaaattca gttcttaact tttttcttga 2465881 tagaaagatg aagctcgtca agctgggcgt cgcttacttc gcctggcgct tctgtcatca 2465941 ggcagcttgc acttgccgtt ttcgggaatg caatcgtatc tctcaggttc gtacgtccag 2466001 cgagaagcat aacgagacgg tctaagccga gtgcgattcc gccgtgcgga ggagcgccgt 2466061 attcaaatgc ttccagcagg aatccgaact gttcagccgc ttcttctggt gagaagccga 2466121 gaagcgcaaa cattttttcc tgaatatcct tttcgaaaat acggattgaa ccgccgccaa 2466181 gctcatagcc gtttaagacg aggtcataag cttgcgcttt catgtcttca ggcgctgttt 2466241 caatcagctc aaggtcttct cggacaggca ttgtgaacgg atggtgcgct gcgtaaaaac 2466301 ggccttcttc cggatcatgc tctaatagcg gccagtcgat gacccataag aaattgaaca 2466361 atttttcgtc aatcagtccg cgttctttcc caagctttaa gcgcagggcg ccgagtgatg 2466421 cggccacaac ttcgaattga tccgctccga acagcagcaa atcaccttca gcagcatcaa 2466481 gtgcttcaat cagcttagac tgcttttctt catcaaagaa tttagcgatc gggcctttca 2466541 ctccgtctgc ctcaaccttc acccaggcaa gcccttttgc cccgtagttt gcagcaaaag 2466601 cgccaagagc gtcgatgtct tttctggagt aatcgccggc accgcctttt acattgatgg 2466661 ctttgaccac gccgccgttt gctacagctg atgagaacac tttaaattcc gtatccttta 2466721 caatgtcaga cacatccgtc aaaagcatgt caaaacgcgt atccggttta tcagacccgt 2466781 acttgttcat tgcttcgtca tacgtcattc gaggaagagg aagctgaagt tcctcacctt 2466841 ttgtttcacg cataaccttt gccatcatct cctcagccaa tgacataatg tcttcctggc 2466901 tcataaagga catttcaata tcaatttgcg taaactcagg ctgacggtcc gcacgcaagt 2466961 cttcatcgcg gaaacagcgg gcaatttgat aatatcgttc aatgcctgat accatcagaa 2467021 gctgtttaaa tagctgcgga gactgcggca gcgcgtagaa ctcaccttcg tgcacacggc 2467081 tcggcaccaa gtagtcacgt gcgccttcag gcgtgcttcc tgttaaaatc ggcgtttcaa 2467141 tatcaagaaa cccattttca tctaaaaagc tgcgaacagc tttcgtcacg ttatggcgca 2467201 gctgcatcgt ctggaacata gccggtctgc gcaaatctaa gtaacggtgt tttaaacgaa 2467261 cgtcctctga cacttcttca gcttgatcag aaatcgcaaa tggaggtgtc tttgcagcat 2467321 ttaatacgtt cactccatca gcatgtattt cgatcgcgcc tgttttcaaa ttcggattaa 2467381 ctgttccctc ttcacgcgcc accacttttc cttgaatatc aagcacgtat tcatttctga 2467441 tgccttccgc aatagcaagc gcttcttttg acacatcagg gttaaaaacg acttgaacaa 2467501 tgcccgtacg gtcacgcaag tcaataaaaa tcaatccgcc gaggtctcgt cttttttgga 2467561 cccagccttt cagcgttaca gattcgccaa ttgctttttc agttatatca ccgcaataat 2467621 atgttcttcc aaacaatgcg tttcactcct tatccctttt ggtttgcctt catcacatgt 2467681 ataaattcat caagtgccac ttcaatctgt tcgcccgtct gtgcatcctt tacattgatt 2467741 ttgttttggg caagctcatc ttcacccaaa atcgcaataa atctggcctt taagcgatca 2467801 gctgttttaa actggccttt cattttctta ttttcataat cgatttcact ggaaatgcct 2467861 gcttctctca gtttgtacac caatgaaaca gaataatcct ttgctttttc gccgagtgtg 2467921 acgatatagc agtcgattcc cttatcaaca ggcagctctc ttttttcagc atcaattgcg 2467981 gcaagcaagc gttcgatgct catcgcaaat ccgatgcccg gtgcttcagg tccgccgatc 2468041 tgttcgacaa gcccgtcgta gcgtccgccg ccggcaagtg tcgtaatcgc gccaaagccc 2468101 tccgcattgc tcataatttc aaatgcggtg tggttgtaat aatccagccc tctcacaagg 2468161 ttcggatcga tttcatacga aatgccaaga tcatttaagt attgtttcac tttttcaaaa 2468221 taagcggctg attcttcatt taaatatgtc aaaatcgaag gtgccgattt catcagctca 2468281 tgatcacggt cttttttgca gtccaaaatt ctaagcgggt tcgtgtgcag ccgggactgg 2468341 cagtctgaac aaaattcttc gatgcgaggc tcgaagtgtt tcacgagcgc ttctctgtag 2468401 cttttgcggc tatcttgatc gccgagactg tttatgacaa gcttaacgtt ttctaaacct 2468461 gctttttcat aaatactcat cgcaagcgcc attacttcag cgtcgattgc agggtctttc 2468521 gaaccaatcg cttcaattcc aaactgataa aactggcggt aacggcccgt ctgaggacgt 2468581 tcataacgga acatcggccc gacataataa agctttgtcg gctgtacagg atttgcgaac 2468641 agcttgtttt cattaaaagc gcgaaccgca gcagctgttc cctccggacg aagcgtcagg 2468701 cttctgcctt tgcggtcctc gaaggtatac atttcttttt gtacgatatc cgttgattct 2468761 ccgacgcctc tggcaaacag ttctgtatgc tcaaaaatcg gtgtgcggat ttctttatat 2468821 tgataagtgc ggcaagtgtc tctcataatt tgttcaacaa actgccagcg atctgattct 2468881 ccaggcagaa tatcctgtgt tcctctcgga atgttatatc ccataggtag acctccttat 2468941 gtattcctta taaaatatcc aatgatcgtt aatgatgaaa atgaaaaaaa ctcccgcccc 2469001 tactatacat gatagtaggg acgagagtta tacccgtggt gccaccctag ttggaatacg 2469061 ttcatattcc cgctcgatcc tttaacgcag gttcacgttc actgcctaat ggcgttattc 2469121 acgcgttcag caggaaacct ccggagtgtt gtttcgagaa agacgcaatg ggatccgctt 2469181 tcagcctggg gcgggttcct ctctaatcat gcaatctgac ctactcttct ccattattgg 2469241 ttcaaatctt tcatcatttg ctatgtactc aatttctatt ataataatgg gattggggtt 2469301 ctctgtcaag ctttattccg gttgtttttc ctcagcgctg cttctttgga cataagacca 2469361 aattcagatg ctgtttccgt aagataacca gtcgtatcgg gatctgcgtg atcgctgtaa 2469421 tgcagattcg cttcaccgtc gtgaaatgca cgtcccattt ttggatgata tttcatgatt 2469481 tgcacacctt tttgattgta tttacgctta gtataaacaa atcattttat ttttatttaa 2469541 aaatcagaaa ggactttacg atattaaaca agaatgcttt tttaatgatc atcagaaagg 2469601 aggacacaat gaacaagaaa tactttgtcc ttattgtatg tattattttc acctcagcgc 2469661 tattcccgac cttttcatcc gttacagctg ctcaaggaga agcggtcatc gcaacagatg 2469721 aaatgaacgt cagaagcggc ccagggctta gctacggcat tacagcggaa gtaaaaaagg 2469781 gagaacgcta tccaatttta aaggaagatg gagactgggt gcagatacag cttggttctg 2469841 gagaaaaggg ctgggtagtc tcctggctta ttacaaagga agaccaggcc agcacaagct 2469901 cctcaggaag cagtgacact gtgacatcaa cagaccccga tctgcggatg agaagcggcc 2469961 cgggcacttc ctacgaagtc atcggcaaat tcccgcaagg cagccaagca tctgtcattg 2470021 ataaagattc gggctggatc aagatatcct atcacagtgc caccggatgg gtatcatctg 2470081 aatatgtcac atcaggaggc agcagttcag cgtctgatga gagtgaccaa accgaggatt 2470141 ccggtgcgtc aacgacgggc acagtcggtg tttcttcgct aaatgtaaga gcctccgcct 2470201 cacatgacgc ggcaattata acaaaacttg atcgcggaac gaaactgacg gttctcaacg 2470261 agaaaaatgg ctgggctcac attgaggtga acgggctaaa aggctgggtt gcaagccatt 2470321 accttttgac tagttctgtt ccagctgatg attcagcaaa tgccggcagt tcatcctccg 2470381 ctaaaaaagc ctatatcatg tacggaggaa cgaatctaag aagtgatgcg tcaacatcag 2470441 cttcgatcgt tgagcgcgct gccaaaggag attcatacac cattaccggt tcaaagggaa 2470501 gctggtatga aataaagctt gataacgggc agactgctta tgtagccaat tgggtggtcc 2470561 aaacgtctaa aagcgcagaa gaagcaggtg aaccgccagt ctctgattcc ccgtctggaa 2470621 acggctctct aaacaataaa acgattattg ttgacccggg acatggagga aaagacagcg 2470681 gaacgatcgg gtattcgggg aaattcgaga aaaacctgac gatcaaaacg gcaaaactgc 2470741 tcgccagcaa acttagatcg gctggagcgg atgtatatgt gacacgccag gatgatacct 2470801 ttgtcagcct gcagtcacgg gtctctacct ctcactaccg taacgctgac gcctttatca 2470861 gcattcatta tgacagctat gcggatacct ctacaagagg cagtacagca tattactaca 2470921 gtcctgccaa agatcaggaa ctcgcatcag atgtccactc agaagtggtg aagcgttctt 2470981 ccattccaga ccgcggcgta ttattcggag attattatgt gctccgggaa aacagacagc 2471041 ccgctatgct gtacgagctg ggatatgtaa gccatccgca ggaagaagcc attgtacata 2471101 gcaattcata ccaagaaaaa gtaacagatg ggatcgaaag cggattagag aaatacttcc 2471161 aataaaaaaa gctgcctttt ggcagctttt tttattttga atccataatg agcgtgaccg 2471221 gtccggagtt tgtaagctga acatccatca ttgctccaaa cgttccggtc tccactttga 2471281 ttcctttttc acgaagcagg tcattccatt tttcataaag acctaaagct ttatcaggtt 2471341 tggccgcgtt catgtagttc ggccggcgcc cttttttcgt atctccataa agcgtaaact 2471401 gtgagacgga taaaatctct cctcctatat ctacaagaga cagattcatt ttcccttcac 2471461 tgtcatcgaa aatacggaga ttgacaactt tatcggctaa ataagctgca tcatcttctg 2471521 tatcatcgtg agtgatgccg accagcacca taaggccttg tccaatttgg ccgacgacct 2471581 cttcgtccac tgtaacgctt gcttctgtta ctcgctgaac aactaatctc ttttctaacc 2471641 cctttagttc atgacgcggc gcacagaata gatatctcta atctgtttaa tacgctcgac 2471701 gactttatgc aagtgattga tattctggat aaaaatcgcc atatggatgg ttgccacttt 2471761 attgcgatcc gatttgccag agacagatga aatattggtt ttcgtttcat tcactgcctg 2471821 gagtacctcg ttcagcaatc cgcggcggtc atacccaaga atctctatct caacattgta 2471881 ttccttgcgc ttttgaactt gtgactcatg ttcccactct accgggatca gccgctcttg 2471941 ggcttcattc gttttgacat tcggacagtc ttcgcgatgg accgaaaccc ctctgccttt 2472001 tgtgataaag ccgacaatat catcacctgg cacaggattg cagcattttg ataaacggac 2472061 aaggaggttg tcaatgccct tgacacgaac gccagcttcc cgttttcttc cttgcgggta 2472121 tggcttaggt tccccagtga cttcctgaac gatcttttcc tgttcttcct ggtcgcgctg 2472181 ctttctctct ttttctgtta ggcggttcgc cacctgcaga gctgtgatgc cgttgtaacc 2472241 gaccgccgcg tacatatcct cttcatttga gaaattaaat ttgtcagcaa ccttttgaat 2472301 attctccggc gttaaaacat ccttcaattc aaaatccaag tttttaattt ctttttcgac 2472361 cagctcacgg cctttttcga cattttcttc acgccgctgt ttcttaaaga attgacggat 2472421 tttatgcttc gcttgggatg tttgggcaag cttcacccaa tcctggctcg gaccgtagga 2472481 atgcttagag gtgagaattt caacgatatc acctgtccga agcttatggt caagcgtaac 2472541 catttttccg tttactttgg caccgattgt tttattgccg atttcagagt gaatccggta 2472601 agaaaagtca atcggaacag aaccggacgg aagctcgatt acatctcctt ttggcgtaaa 2472661 gacatacacc atgtcagaga acaaatcaat tttgagcgat tccataaatt cttctgcatc 2472721 tgtcgattca ttttgaaatt ctaaaatttc acggaaccaa gaaagctttt tctcaaaggt 2472781 tgcaccttca ttggctgctt tcccttcttt ataagcccag tgagccgcaa ccccgtattc 2472841 cgctatttca tgcatttcaa aggtgcggat ctgcacttca agcggatcgc ctttaggccc 2472901 aataaccgtt gtatgaagcg attgatacat attcggcttc ggcattgcga tataatcttt 2472961 gaatctgcct ggcatcggtt tccagcatgt gtgaatgatg ccaagcaccg cgtagcagtc 2473021 ctttatgcta ttcacaagaa tacggacagc caacaaatcg taaatttcat tgaattgctt 2473081 attttgcagc accatttttc gataaatgct gtaaatatgt ttcgggcgtc ccgagaagtc 2473141 agccttgata tttacttctt cgacacgttt cttcacttca ttgacaacct catcgacata 2473201 aagctctcgt tctgcacgtt tcttcttcat gaggttgaca attctgtaat attgctgagg 2473261 gttcaaataa cggagcgccg tatcttccaa ttcccactta atttttgaaa tcccgagacg 2473321 atgcgccaaa ggagcaaaaa tttccagcgt ttcattggag attctccgct gtttttcctg 2473381 aggcagatgt ttcagtgtcc gcatattgtg aagacgatcc gccagcttga tcaatatgac 2473441 cctgatatct tgagccatag cgacaaacat tttgcgatga ttttccgcct gctgttcctc 2473501 ttgagattta tatttaattt tgccgagttt cgttacgccg tctacaagca ttgccacttc 2473561 ttcggaaaat gcttctttca ggtcatcgag cgtcacatct gtatcttcca cgacatcgtg 2473621 caaaaatccg cccgcgattg tggaagggtc catttcaaga tcaacgagta tccccgcaac 2473681 ctgaatcgga tgaataatat atggctcgcc cgatttgcgg tattgctcgc gatgagcatc 2473741 ttcagcgtac agatatgctt tttcgacaaa tgcgatatgc tcatcagata gatagctgcg 2473801 tgctttatct ataacttgct cggcagtcaa tacttgttcg ttcgccatgg aatcaccttt 2473861 tttaaaatgt aaactgtatt gtagtttatt atcaagaaaa aaacgaaaga tgtaaagagc 2473921 agaagttcaa atagccaaat attatataaa ataaatgcaa aacaatagga aaaaagcacc 2473981 ctgacatgga gtgctttttc gttatgcggt tatccttagt atttcatcaa tgttaagatg 2474041 tcgtaatctt cgagcttatt tctgccgtca aggtaagaaa gctcgattaa gaaagcgata 2474101 ccagcaacaa cgccgccaag ttcttcaaca agtttgattg tcgcttcaat tgtgccgcct 2474161 gtcgcaagca ggtcatctgt aataagcaca cgctgaccag gcttaatcgc atctttgtgg 2474221 atcgttaata cgtcttttcc gtattccaag ccataatcca ctttgattac ttcacgaggc 2474281 aacttgcctt ctttgcggac cggcgcaaaa cctacgccaa gcgcgtaagc aacgggacag 2474341 ccgataataa agccgcgcgc ttcagggcca acgaccaaat caatttgctt ttctttcgca 2474401 tattcaacaa tttgatctgt ggcatagcgg tatacatcgc ctttatccat cagtgtcgta 2474461 atatctttaa attgcacgcc ctctttcggg taatccggta caattgttac gtattgtttt 2474521 aaatccatct gttttatgtc ctcctcgtac tttcataagc ctctgaatct tgtttcatca 2474581 gcttattcag ccattccttc agctcttcag cagaagaata attcagcttt tgatccagtt 2474641 ccatcagctg ctgtttcgcc tgatatgttt gtgagtctgt taagtcgcgt ttctttgctc 2474701 cgctcacaac agacagcaca ccattctcta ttttaacaaa accgagatca aaaaacacct 2474761 ttgtcatgaa attgattgtt tcaacggacc agcctttatg ttttgcaagc tctgaaccgt 2474821 gttttttcac gtcaaaagcg cctcttttca gcaagaacgc ataataccat ttaaagtggt 2474881 ctcttgcggg aaaagttgat aaaaagtggt cctcatgatt gagaaaaata aaatatatcc 2474941 gctcgggcgc ctttccttcc agcaaacgtg cgagcatgtc cagcgaaggc ggcggatcca 2475001 gtaatacaat atatgcacca tcgaggtcaa acgcctttgc ttgatcttta gaactgatga 2475061 cgtgcacttc tcggcgaagg tcttcagttt gaagtaatgt tgttgagtct tctttgaaag 2475121 agacaatggc ccgtttagca gatggaaggg cggaaactgt gtcttcccac gtccgttttc 2475181 cccttaaatc aaacagctgc cattcagaaa cagcggcatc ctttatcata agctgcggct 2475241 tttttcgatt gttccattcg ttgattgaca tctcaccgac aatggaaatt cttgaacccg 2475301 gtacgatgcc ttcttgaagc tcgcctttat taaaaccgac gcaatcaagc tgggacgact 2475361 cgtttctgat cgtcattttg acatgagttt tatttgcccc tatcttgcgg acatcttcca 2475421 gtactgcatt ttctacgaga acgtgcggtt tcgggttcag catgccaaaa ggagacagca 2475481 tgttcatttc tgcgatgctt tcaactgtaa tgtcttcgac gccgcagaca aggtcgactt 2475541 cctgtacggg aataaaatcc tcttccgtaa gcgtattgtc cgctatttca ttcagcctgc 2475601 ttcgcaaatc cggcacatct tcggctttca gcgtcatccc cgcagccatt ggatggccgc 2475661 cgaaatgagg aagaatatct ctgcattcag aaaggctctc aaataaatta aatcctctga 2475721 tgcttcgggc cgaaccttta gcgattccct tttcttcatc aataccaaga acaatggccg 2475781 gtcggtagaa acggtccaca agctttgaag ccacaatccc gacgactccc gggttccatc 2475841 cggctttggc cacgacaatt gcagtttgat cgagcccttg ctgttcaacc atttcaatcg 2475901 cttcatccgt cattttgctg accatttttt ggcgctcttt gttcagctgg tcaatttctg 2475961 cggcaagctc ttccgcttca aacgaatcct ctgacataag caaatgaaca gcgggatccg 2476021 cctgttcgat tcttccgacg gcattcagcc ttggtgcgag ctgaaatccg actgtttctt 2476081 cgttcgcttc tccgatgtct ccgcctgaca gcttaatcag ctcttttaag ccgagccgat 2476141 ttgtccgtcg aagcctttca agtcctagtg ttgctattaa tctgttttcg tcatgcagcg 2476201 ggactagatc ggcaatggtg ccgatagccg ccaggtcaag cagttcatca ggaagttcac 2476261 ccaataaagc gtgggcaagc ttaaacgcga ctccaacccc ggcaagctct ttaaacgggt 2476321 aagtgcagcc aggctgcttc gggtggacga tcgcacggac atccggaagc tccggtcccg 2476381 gttcatgatg atcggtaatg atgacatcca gtccgagttc ctttgccacc ttcgcttcat 2476441 gcacagcggc aattcctgta tcaaccgtaa tgatcaaaga gaagccccgt tctttaatcg 2476501 aacgaaacgc ctgttcatta ggtccatatc cttctttaaa acggtcaggt atataaaaat 2476561 caacttgagc cgacagtttt tgcagcgtgt gaagcatcac tgacgtactt gtaaccccat 2476621 cggcgtcata atcgccatat atcataatct tttcttgttg tgaaatcgcc tgttttattc 2476681 gatctgccgc ttctttcatg cctttcattt caaaaggatc ataaaaatcg gcatcctttg 2476741 tatgtaaaaa cagcctagcg ctttctgccg tatcaaagcc tctttttaca agcagggacg 2476801 caacaagagg tgttatatgc aattgttctg tgagtgattt gaccttatcc tgatctggtc 2476861 gctggatttc ccatcgcatt tttgacgcta acataaattc acccctcaac caccctatta 2476921 tactagagca ggctgagggg tttcaaataa tattcgaaaa ctagtctttt ttctcaatca 2476981 tggctgatgc atcctgtgtg tcagtctgat cagcaagatg agtatcctct tgtttatgta 2477041 ttgctgttct attttctttc cgcaaggttt ttatttcccg cttcaatttc attacctgaa 2477101 aaatgccgac agaaaatacg atcagtgctc ccattaaaac tgagcccaaa ataacaagaa 2477161 tgagcggcca ttctgatctt ccaaacaggt aatcaacttc tacggatcga acattaatga 2477221 ctgcgaaaat agcgacaatt aaggtgaaaa taagtgcgaa aataatggtc cattgtttat 2477281 tcattctctt ttcccccaaa cttcttattg aggtaacttt cccaatcaag actggtttta 2477341 aacatggctt aacactaggt taagctccct ttgctgttaa tttttcccgg atcagcctct 2477401 tcagtccggt tccctcaccg gaaatcacaa gtgtatcgcc ttcgtcaatg actgtttcag 2477461 agctcggatt cagttgttta tcctgattct ttttaacaat tgcaatgacc gtcacatgat 2477521 attcctgacc cacattcaaa tcaccaatcg tctgatgaat ggcaggcgct cccgcctctg 2477581 ctttacacca ctctataatc aaatcatcaa gggctgactc gacctgttct aatgctttcg 2477641 gtttatatgc cattccgcca agaattgcag acatttgcct tgcttcagcg tcatcaaact 2477701 gcacggaggc aacacattcc tcatggtcgt tttcgtcaaa atagtaaagc tctctccgtc 2477761 cgtcatgatg aatgataatt gaaattttat cacggtttct agtaatcatt tcaacttttt 2477821 gtcctatgcc cggcagctct gattcgcgaa ccctcatata taaaccctcc tacatatctg 2477881 aaaaccagcc ataaacactt ttaacaccat atatatgttt aaatgtaagc gtatgtcatt 2477941 atagcaaatg tctattttaa gttcaatgaa acttcaaaaa acaggctgcc ctgcagagga 2478001 cagcctgata ttttttattg cgccgaatct tttttcagtt ctcttccttt ccatgcaagc 2478061 caaatttgtg cggcaatgta tagagaagaa taaacgcctg ttaacagccc gaccaataaa 2478121 gcaattgaga agttagtaat agaagatgct ccaaagatca gcaatgtcac aacaacaatc 2478181 acaacggtta atacagtgtt aattgaacgt gtaaaggttt gctgcaggct caggtttaca 2478241 atatggttca gatcggcaaa ggttttcggc ttacgctttt tcatatgctc gcggaccctg 2478301 tcaaatgtaa cgattgtatc gttaatggaa tacccgatta tcgtcaagat ggccgcgatg 2478361 aatgtaacat ctacctcaag ccttgtaata ctgaagaacg tgacgataaa gaatgcgtca 2478421 tatagcaatg aggcgatggc agcaatcgcc attttgtatt cgaatcggat tgaaacgtaa 2478481 ataatgatgc caatagaagc tatagcaact gcgtacagcg catttctcgc cagctcctta 2478541 ccgactgtcg gtgaaactgt gctgacattt ggatcagatc cgtatttgtc tttaaaatac 2478601 gtttttactt ttgcaatggt ttctttatct ggcaccccga caaaacgggc aacaccgata 2478661 ttgctctttt cgcctgacag aactacagta tcagggtcca tacccagaga ttcaaaatcc 2478721 ttctcaactt gctctgtcgt cagcttatgg tcgctttgca cttcaatccg tgcaccgctt 2478781 gcaaagtcaa tgccaagatt cagcctgaac acaagcagga taataatccc ggcaaccgtg 2478841 accgcactgg agaaaataaa gaagtatttg cgtttgctcg tgaaatccca tttttggaat 2478901 ggcgtatgcg gctctgtatt ttcatccgta tcctgaatat ccatgatatg tttcttattg 2478961 acaccaaacc agcctttttt ccgatcaagc catctgcttt ccacaaggag agcgaggaga 2479021 aatctcgata agaaaacggc agtgataaag cttgtcaaaa tcgataggat cagcattgtc 2479081 gcaaaccctt taacagagct tgtcccaaag ataaagagca caaccgctgc aataatggtt 2479141 gtaatattcg cgtcaaaaat cgtcgcaaat gaccgtctgt ttcctgaacg gaaggcagag 2479201 cggactgact ttcctagctt gagctcttct ttaatccgct cataggtaat aatgttggcg 2479261 tcaacagcca tcccgacacc taaaatgaga gcggcaattc ccggaagcgt gagtacggca 2479321 ttcatccagt caaagatctg gagtgtaatg tagatataaa cagacagcgt aatcaccgcg 2479381 attaatcccg gcagacggta atagaaaagc ataaataaga aaataattgc gataccgaca 2479441 ataccggcaa acaccgtatc atggagagcc tgctggccga attgcgcgcc tactgatgtc 2479501 gaatactttt cagtcagttt cacaggaagt gcgcctgcgt ttaaaatgct ggctaaatct 2479561 ttcgcttctt gagctgtgaa atgaccttca atttttacat cagttgtatt tagttcctga 2479621 cttacatttg gagcggatac aaatttagga tgctcttttt gaacttcttt cttaaaggaa 2479681 tcacctttat cataatccaa ccaaatgaca agctggttgt ttggcgccat tttcatgacc 2479741 ttcttggtca cttcaccaaa tttatcagcg tctttcagct taatcgtgac aattggctca 2479801 tttgttgtgc tatcataagt ttgtttagcg ccgttttcga ctagatcagc accgtttaac 2479861 agttccttat catttgcatc tctgaaagaa agctgcgctt cagtcgccaa aatttcacgc 2479921 gctctgtttt ggtttgtcac gccagcgagc tgaacgcgaa tccggttatt cccttcaatt 2479981 tggatgttcg gttcgctgac accgagaaca ttggcccggc ggttcagtgc ctctactgtg 2480041 ctgaccagaa cgtcttttgt gattttgtca ccttttttta caggctgtac atcatacagc 2480101 acctcaaatc cgccttgcaa atccaatcct aacgtaatat tgttagcggc aggcttcgta 2480161 aagtagccca agcccgtgcc gatcaataga acgaaaagga aaaacgcaat caagcgtcct 2480221 tttttcatta tgtatatcct cccttaaacc tgtgcgaatc aacctgctat ctcagcagtt 2480281 cttccaatgc ttcctggccc tcttcactgc ccagccaatt agacgtttta aatgactcaa 2480341 cggttgcata gttcataaat tcgccaattt tcactgataa aatatcactc gccagttcat 2480401 aaatgctcag ttccgttttc tttttccact tcttatctgt taagtatgac cacaaacttt 2480461 cgagttcaac atcatcatac ccgagaatct taaactcttc cagtttgctg taaagaaacg 2480521 gcctgacgtg gtctttatat agatcggctg gatgcttctc cacgaattcc acgctccttt 2480581 tttattgttt ttcaagaaga cttgtcatgc ttggacgaca tatacgcata tctttattgt 2480641 atatgattcc aggtagtttg agaaggcagg gggtaaaaat ggcgaaacag acgtttttaa 2480701 agggcactct tatccttatc gcagcaggaa tggttacaag aatgctcggg tttgtcaacc 2480761 gggtggttat cgcccgtttt atcggtgaag aaggagtcgg gctttacatg atggcagcgc 2480821 ctactttctt cttggccact acattaactc aattcggtct gccggtcgcg atcagcaagc 2480881 tagtcgctga agccagtgcg cgcggagatc atcaaaaaac gaaaaatatt ttagtcatgt 2480941 ctctgaccat tacgggagtg ctcagcctca tctttacacc gctgtttctg tttttcgccc 2481001 ctgttatggc tgaaacgatg ctgacagata agcgaacact gtatccgctc ttggccatta 2481061 cgcctgttgt gccgattatt gctatatcga gtgtgctgag gggatacttt caaggaaaac 2481121 agaatatgaa cccgcttgct atgtcacaag tccttgaaca ggttgtccgc atttcactcg 2481181 tggctgtctg cacaacgatt tttctccctt acggaattga atatgctgca gcgggggcaa 2481241 tgctatcctc agtggcaggg gagctggcat cacttcttta tttattcgtt tgctttaagt 2481301 ataaaaagac aattaaaatc agaaagcatt ttttacagtc aattaaaaac ggaaaacaaa 2481361 cctttaccca attaatgagc gtgtcccttc caacaaccgg gagccgcttt atcggaaacc 2481421 tctcttggtt tttcgagcca atcgtcgtcg ctcaaagcct tgccatcgcc ggtgtggcaa 2481481 cagttgccgc aacaaagcaa tacggggaac taaccggctt tgccatgacg ctgctgactc 2481541 tgcccagctt tattacatat tctttgtcga ccgcgcttgt tcctgcgatc agtgaaggaa 2481601 tggagcagaa aaaattgcag gtggtggaat accgcttaga acaggcgatg cgtctctgtc 2481661 tgctcagcgg aggcatttca gttgttattt tatttgtatt tgcggatgag ctgatgagag 2481721 tgatgtacgg ttcctcaggc gcagctgtat ttataaaagt gatggccccg ttttttctgc 2481781 tttattattt ccaaggcccg cttcaagctg tgctgcaggc gcttaatttg gcaggagctg 2481841 cgatgatgaa cagcttaatc ggagcgcttg tcaaaacagg ccttattttt gtccttgcca 2481901 caaggccttc tcttggcatt atgggcgcgg cattagccat tgtgacaggc atggtgctcg 2481961 tcacgctatt gcacgcagca accgtaagca aagtgctgcc gatcagcatc aaaatcaagg 2482021 agtacgcgct cagcttcgct gttattgtaa tttgcggatt catcagctcc gccatcaaac 2482081 aatatataag ctttggagca tctgaggctg tcaatctagc cggatggatt gcggcgagcg 2482141 ccgccattta tatgatcctc ctgctcgttt tccgtttaat taaaaaagat gagcttcgcc 2482201 gcattcccat tatcggacgg ttgatcatcc gataatggtc acgtgcggtg cccatctttt 2482261 tcatcaatat atatttctcc gtctgtaaac gagcaaaatg aaatatctga agggtttgtg 2482321 tatccgtgtt tttgcaaact ttcaagcagc cattttctat ctttactgat tctggacagg 2482381 ttttctgttt gaatgaagcc gtctataatg agcggcattt cgagctgccg atgctctccg 2482441 ctgttttctt tcttaacaat agtcagtttg cccgacggct ctaaaatagc aaatgatacg 2482501 tcagctactc tgtcgatgct attttctctg agctgaacca ttaaatcatc aaaattataa 2482561 cgctgtgatt tcatggcttc ttcgtcaatt tttccatatt tgataattat ggtcggctta 2482621 ccgtcaagaa gctggcggac ttttcggttt tttaaagaaa agtatgccaa agtcacttga 2482681 atgatcatta atacaagcat tggcaaaatg gtatgaaata gatgatcgtc tacgttttct 2482741 atggctaaaa cggcaatttc agccatcatg ataaagacaa cgagatctaa aatactaagc 2482801 tctccgatct cccgtttgcc catgaaacga aaaatgacca atatcacaaa atacaatacg 2482861 actgtgcgaa acgcaatagt gagaagctct tccattatgc acctccaact cattataggt 2482921 tgcaacaaaa tgatcaattt atgtaagaaa aaccgattgc atttcacaaa gcttttacgt 2482981 ctaattcatg ggataaggga atacattttt acaaagacga gccatcagca tgtctgacgg 2483041 ttttgaacaa aaagaacaga agccttttaa tacaggcaga gaggagacaa tcatggagga 2483101 aacgaaacaa gttggaaaag gcattcttta cggcttaatc gccatatttt cagccatgct 2483161 cctgacaagt ttagcggttt cacttttatt gaccgcaacc tcgctggaag aatcatcatt 2483221 taactggctg atcaccgcta tctcatttct ctctttattt atcggcgggt tcatttcagg 2483281 cgggaaaggc aaggaaagag gctggatgat tggcgcattg accgccttaa gtttttctct 2483341 gattatctta ttgtttcagt atttaggatt cggaaagaca tttacagcag aacagctgat 2483401 cttccatctg ggatttttag gggtgtgcat gctgggcggg attttcggcg tgaacatgag 2483461 gggaaacagg tcttccacat aaaaaagagc gggctcactt gcccgctctt ttttgtttgc 2483521 tatgtatagc tcctgctgtt attcagcagc agaaacttct ctgatcgcgc ggcggtcgaa 2483581 cgtaagacgt gtgttatcac cagtcttaat tacgactttg ctttcgtcga tagagtcaac 2483641 agtaccgtgc aatcccccga ttgtcactac tgaatcgcct tttttcagtt cctcttgcat 2483701 ttggcgtaca gccttttgct gcttttgctg aggacgaatc agcaagaagt aaaggaccgc 2483761 aaacattaaa ataataggaa ccaatgtacc taaagtgcca gtcatcattt tcaccccttt 2483821 ctgtaagcct gttatgttta tttagaagct tttcgcattt ggcttgttat agccgtaacg 2483881 ctcaaagaac tcttctctga aatcacccag acgatcctcg cgaatagcct gtcttacctg 2483941 ctccattaag tgtaacagaa aatgaaggtt atggtaagtt gttaatcgaa ggccgaatgt 2484001 ttcattgcag cgaatcaagt gcctaatgta cgcgcgagtg tagtttttac atgtatagca 2484061 atcacactct tcatcaatcg gacggaagtc tctttcaaat ttcgcatttt tcatattgag 2484121 tcgtccttca gcagtaaaca ctgtgccgtt tcttgcaatc cgtgtaggca gcacacagtc 2484181 aaacatatcg accccgcgga tcgctccgtc gatcagtgcg tccggagaac ctactcccat 2484241 cagatatctc ggtttatcct tcggcaagag cggtgttgtg aattcgagta cacggttcat 2484301 gacatccttc ggttcaccta cagacaatcc gcctatagca tatcccggaa aatcaagcga 2484361 aatcaagtcc ttcgcacttt gtgtccgcag atcttcatat tctccgcctt gtacaatacc 2484421 aaacagccct tgttcatcct gacgattgtg ggcattcagg cagcgttccg cccagcggct 2484481 tgtccgttca actgacctct tcatgtagtc gtactccgcc gggtatggcg ggcattcgtc 2484541 aaacgccatc ataatatcag agccgagtgc gttttggatc tccatcgctt tttccggaga 2484601 taaaaacagc ttgtctccat ttagatgatt gcggaaatgg acaccctctt cctctatatt 2484661 acgaaacttg cttaaagaaa agacctgaaa accgcctgaa tctgttaaaa ttgcgcggtc 2484721 ccagttcata aatttatgga gcccgcccgc ttctttgaca atgtcttggc ccggacgaag 2484781 ccatagatga taagtgttgc tcaaaatgat gcctgcatcc attgctttca gctcttcagg 2484841 cgacattgtt ttgactgtcg ccagtgtgcc gaccggcata aaaaccggcg tttcgaagga 2484901 gccgtgaggc gtatgcactt tgcccagccg cgctcctgtt tgtttgcatt cttttataaa 2484961 ttcatagcgt attggttgtt cagccacttt tgatgaggcc tcctgttctc aaattatata 2485021 atcagcatcg cgtctccgaa gctgaagaaa cggtattcct cttccactgc atggttatag 2485081 gcacgcagaa tgttttctct tccagcaagc gcgctgacca gcataatcaa tgacgatttc 2485141 ggcaaatgga agtttgtaat cattccgtca atggctttaa attcatagcc cggataaata 2485201 aaaatagatg tccagccgct tgatgcttta aattgcccgt catgttctcc ggcaatcgtc 2485261 tcaagcgtgc gtgtcgaggt cgtgccgaca gaaatgatcc gaccgccatt ttctcttact 2485321 ttgtttaagg ctgcagccgt ttcttctgac atttgataaa actctgcatg catattatgc 2485381 tcttccactt catcggcact cacagggcga aacgttccaa ggcctacgtg cagtgtgatg 2485441 aactcaattt gcacgccttt gtctttcagc tgctgtaaga tttcttccgt gaagtgaagg 2485501 ccagctgtag gcgcagcagc agagccaatt tcttttgaat acactgtctg gtagcgctct 2485561 ttgtcatcaa gctgttcttt gatatatgga gggagcggca tctctccaag ggattcaagc 2485621 acctcgtaga aaataccgtc atattgaaat tccatctttc tgccgccgtg ctcaagctct 2485681 tccgtgcaga ttgccttcaa tcttccgtct ccaaatgtga caacagttcc ttttttcacc 2485741 cgtttcgccg gtttggcaag tgtttcccat ttatcaccgg tttcctgttt caacaaaaga 2485801 agttccactt tcgcgccggt atcctctttt gtgccgaata accgcgcagg cagtacccgg 2485861 gtattgttca ggactagaca atcgccttcg ttaaagaagc tgataatgtg tttaaacgag 2485921 ctgtcagtaa gctctcctgt atgtttatcg agcaccatca gccttgaagc atcacgctgc 2485981 tccaacggta cttgtgcaat taaacgttct ggtagttcaa aatcaaataa atcgactttc 2486041 atgatgattt cacctttatt ctagtctttt gttatttcat tctgccaaaa agattaagca 2486101 aaattgataa taccacactt ataataatac aagtgacaac cgggaagaaa aacgtaacat 2486161 ttcctttttt tacaaaaata tctcccggca tcttgccgac aaaatgcaaa actgctccga 2486221 taataagcaa aacagcacca agaatcataa tgatcttagg aaattcagtc atatcgggga 2486281 gcctccattt ggaaatgatg ataaacggcc ggtgtcacga tccttccacg cggcgttctt 2486341 tgtataaatc caatttgcag cagatatggt tcatatacgt cttcaatcgt atgcgattcc 2486401 tcgccgatgg tagctgaaat cgtatcaagg cctactgggc cgccgttgaa tttttcgatc 2486461 atgcccatca gcagcttatg atcaatatga tccaaaccga ggcggtcaac ctgaagccgc 2486521 tccagcgcat tctgagaaat gtcttccgta atcctgctgt cacccagcac ttgggcgaaa 2486581 tcgcgcaccc ttctcagcag gcggttcgcc acgcggggcg tccctctcga tcttcttgca 2486641 atttcaagag ccgacggttt atcaatctca acctcgaata catcagcggt tcttgtgaca 2486701 atatccgcca gttcttcttg tgtatagtac tcaaggcgag acattacgcc gaatctgtct 2486761 cttaaaggag ccgtcaaaag ccccaccctc gtcgtggctc ccaccagcgt aaaaggcgga 2486821 aggtcgaggc gaaccgagcg ggcagatggg cctttgccaa tcacaatgtc caggcaaaag 2486881 tcttccattg caggataaag cacctcttcg atcgatctgt gcagcctatg tatttcatca 2486941 ataaataata catctcccgg ttccagcgcc gttaatatag cagccaaatc accaggcctt 2487001 tcaatcgcag gccctgatgt cgtccgcaat tccactccca tttcattagc aacaatcgaa 2487061 gcaagcgttg tttttccgag tccgggcggc ccgtacagaa gaacatgatc cagcgtctcc 2487121 tgtctcattt tcgccgcatc tataaacacg cgcaaatttt cttttacctt atgctgcccg 2487181 atatactgtg ccagattttg cggcctcagg ctttgctcta tcactgattc atggttgtct 2487241 gcttcacttg agacgagccg ttcatccatg aacatcacct tactttaata gtttttgtaa 2487301 tgcttttttc acatattggt ctgttgtcag cccaatttct tctttaaggt gaggaagcac 2487361 ctttttgatt tctttttcag catatccgag aaccctgagg gcttcaagtg cttcttcaag 2487421 agccgtttcc gctgtttgct tttcaagcct ttcttcatga ttaaacagat tttcaatcat 2487481 ttcaggcaca acatctgcca gctttccttt taaatctaga ataatctggc gtgcggtttt 2487541 ctttcctact ccaggaaact tgaccaaaaa agcttcatct tcattttcaa ttgcttggat 2487601 gaccgctccg ggatcacccg agcccaagat ggcaagtgct cctttcgggc caattccggt 2487661 cacgtttaac agctttgtaa agagcgcctt ctcctctctt gttgaaaaac cataaagcga 2487721 aaaagcatcc tctctgatat gatggtatgt aaaaatcgtt tcttggcttc tctccttata 2487781 tataaacgga ttcggcgtga aaatctgata gccgatgccg ccgttctcta tgacaatata 2487841 ttggggagat acataatcaa tcgtcccttt aacaaattca atcacgcaaa ttcacctctt 2487901 tgactgttct tcattgtacc ataaaaacag ccaaagtctt atagaaaagt taacatatgt 2487961 tcgcttctct ctcattcttt cacgaaaaaa aagacatgaa tacatgtctt caatcagcgg 2488021 acgctacccg ctgtatgtct tcatatgttc gatgacatcc tcaaactccg cttttgtccg 2488081 aaatggaatg cctttcagca gatttttttg catatggctt tccagccttt ctaaatcaat 2488141 ttgaaaaaaa gactgaattg gttcggaagc tggctcaggc cgcccatgaa aagtggaaat 2488201 cactccatta tccgatacac cgatataccc gttgaccttg ctgagcggag aaatatcgtc 2488261 catttgcttc cggaagagca catatccctt tttttgttcc actagcgtcc atccggcata 2488321 agctgcccaa aaatcatcca tagaaaacac tttttcatgc ttatgctcaa tgctgacatc 2488381 gccgtccaaa tacacctttt caagctgcac atgcacctgc agcggctcat agtgctccac 2488441 ttccgcgcca agtgcgcggg aaggagctcc tattaaaaat actgccgctg agcaaagaat 2488501 gcccagcaaa agatacgccg tgctgaatcg tttcaccctc tacacctctt tgcacacgtt 2488561 tatgattagt ttgaccaaag aggctactgc ttaaccgttt tatcaaaatt tgtctgcaca 2488621 ttttccctga caaaccgttc ctccgtatac acatctgtgc tttgctcaga aattgtcaag 2488681 aatcgcgtca gaaaggcact gaaaaaatac aatgccgcaa agatccaaat cacgccacct 2488741 gcaccgagcg gcccaatgaa aagactcacg atgcccggcg cgataaacgc acataaacca 2488801 gatcccaaat tcaacactga catggcagca cctttattat caggtgcaag cgtcggcaaa 2488861 agcgcgctta atgggacgta ccctgctaaa gccgcgccgt agcagcaggc gataatcatg 2488921 agcacccaat actgatgccc gatcagctga ggcgtgtaat acagcgccag cgtaaaaata 2488981 ccgcatccga caccgccaaa ccacatgacc gtattgcgcc agcctagttt atctccgact 2489041 gcaccgaaaa tgatattaaa cacaatattc acaaaaaaca gcgtccccca tatttgcagc 2489101 cattccgaaa ccgaataccc gtatcgtgct aaataagtag gaagaaagat ggcaaatcca 2489161 aattgtccta tcgcattaat cgtcttgacc actccgccga tgcctacctt agggttttca 2489221 aacataatcg taaatgcctt cgacagttct ttccatttcg gctgatcttg tttttgtatc 2489281 ggagtaaatt tatctttgtt aaaaaataag gcaagaattc cgcctgccgc cacaaacagt 2489341 aaagcgctcc aaagcgtatt gatttctcca aaggccggaa ctgcatagct ggaatagaac 2489401 ggaccgagca cgttaaggcc gcacgtaaac ataaaccaaa accagccgac ggcttttcca 2489461 agaatatttt gagaggtgct gtatgacacc catacgagaa aagagtatgc aaacagcgga 2489521 tatcccaagc ctctaagagc atagctgccc aagagagccg gataatacat atgaggaatc 2489581 gcccagccga taaaagcggc cgaaccgagg ataaatgcaa gcaatccgac agtcatcgtt 2489641 tttctcggcc cccaagtttg gacaaacgtt cctgaaagcc aagctgagat ggtgacagca 2489701 atgccgtaca tggtaaataa cgatgcggat tgctgcatac tgagaccatg atcaacgaga 2489761 aaaggagaca gccagccttg ttcgaggccg tctccaacca taaagatgac aacgccaata 2489821 taaccccaaa ccatgtgaga aggaattccg attttgttca aaacatttcc tttagcatgt 2489881 actgtattca ttttctccac cgcctactta aagtatcaat ggagtatata cccaagcttg 2489941 ctgaattgta atcctgttag attaaaaagc gattttttca gtgtgctcaa tgctaacagg 2490001 catgccaaaa gcaagcgatt gctgtgctgc tctggcgatc ctcccggcct gtaaaccgtc 2490061 attgccggtg cagggagtct cctggtttgt gccgatcgct tctgcaaaac ggagaatctc 2490121 ctcctcatat gaatccttat agcgttcaag gaaaaagaaa tgcggtttat ccttcatcac 2490181 aaaatcagct gttgacacct caaccgttgt cggcctgcta ttgtcagccg ctgcagagcc 2490241 tttcgtcccg aaaacctcaa cccgctggtc atatccgtac acagcttggc ggctgttatc 2490301 aatcacagcc atggcaccgt tttcaaaagt cagtgtaata acagctgtat caatatcacc 2490361 cagctccgca aaagaaggat tcaccaaagc cgcccctttg gcatacactt ccgtcacttc 2490421 gcttcccata atatatctgg ccatatcaaa atcatggatc gacatatcca taaacaatcc 2490481 gcctgacgta cggacataat ctatattcgg gggttctggg tcccgggacg tgatttttaa 2490541 taaatgaggt gtaccgattt caccattttc aacaatcgtt ttgattttct taaaatgagg 2490601 atcaaagcgg cggttaaatc cgacttgaag tgttaccccg tgtttccgga cagccgcaag 2490661 cgcttcactc gtttcgtcca gagagaaact aacgggcttc tcacaaaata tatgcttttt 2490721 cgcctcggct gcttctttga tcatctgtgc atgtacggct gtaggagagc aaataaaaat 2490781 agcatcaata tcaggatcat gtaataaatc acgataatca gaggttatgt attcaatctg 2490841 atgactgtcg gcccagcttt ttatacggct cgcctgaatg tcagagattg cttttatttt 2490901 catgtgagga atccggctta tattttgaac atgaagtttg ccgatgcggc ctgcaccgat 2490961 aatccctgtc acaatctgtt ttgtcatggc ttcttccccc ttgatcattc acgaaagcgc 2491021 tttatttaaa attaatacta tcccatttgt aagcgctttt caagaatgga aattaaacgt 2491081 tctatgtctc ttttatcaca attcatgctt ataagtagcc ttcttcttca agaccagata 2491141 cactagaatt aggctctttt tcctgaacag tttatgattt tcctataaac agctgcataa 2491201 aatagagcaa agaaggtgaa tgaaatgctg acaaaagcag aggcactggc ccataccgtc 2491261 atataccgca agaacagcag atttgataaa gtcaaagaga aatccgagga attaacacta 2491321 atcggcaagg gaagaagcgc ctatgtgttt gccttaacag aaggcggtcg aaaaatggcg 2491381 ctgaaagtat tttttccgga atatcaagcg acagcagtca aagaagcagc gatctatgaa 2491441 aaattagccg ggtccgcatt ctatcctgac atttacgaaa ctggcgattc atttattctc 2491501 atggaatata ttaaaggtga aaccttttat aactgtctga agaaaggcat tgcaatcagt 2491561 gatgacatga ttcagcaggt tgaagaagcg ctttctgacg cccgggcagc cggactgaac 2491621 ccgtcagata ttcatttgcg gaatctgata ttgacagaaa ccggggcggt gcgggtgatt 2491681 gatgttgcga gatttgagca gacaaaaaca tgcacgcagt gggacgactt aaaatccgca 2491741 tatcatgcac tctacaaaaa accgatattc cccaaaaaga ttccgggttt ttggctggag 2491801 atcatcgcat ttttatataa gaaagattgg tttcaaaagc atttcgcaca gcggaaaaga 2491861 aaatattctt aaatcaaaaa ggcagccgca caagcggctg cctttatcat gtatttttta 2491921 ctttctgacg gcagaaatca gtttcatttg ttcaggcgac agcttaattc gatagcctct 2491981 cacagttaag tagaccgctt ctgggtcctt ctcgccggaa tgacaatacg ttttttccat 2492041 ttctgtctcc cctcaccctt tattggcttt atttcatctt atcattgctt tattgaggta 2492101 attttaaaga aatgtaaaga ttatatgaat ccgatatata gtaaaatgag agaaaaaaag 2492161 ggagagagtc acattaagac cgaaaacacc ttgagcttag atgcagccag aggtgaactt 2492221 gtaaatgaaa aaacacttgt caagagaaca atctactgga attacccgga cagccgccca 2492281 gcagtgacgt ggatcaatca caatacagtg aaaatcggca atcagacttt acatcttgat 2492341 actgatgaaa cgtatgattg gcgaaaagat gatcattgga tccgtgaaga accgccgcag 2492401 gcgtcagtga ggtgatgaaa catgaataag atgaacggaa caaatgatga aaagcatttc 2492461 aatcattttg tgattgcttt atcctttata tacggtttga ctgaactagg ctatttgttg 2492521 ctgaaggatt ttataacaat tgccataagt ttgcctctgt agaaaaacgc agcgtagtcg 2492581 atacgccgcg ttttttcttt ttcccttcct cttcttattg ataattacag gtcatataat 2492641 gtgacaaatc gattgtagaa atagttcgat tagaccaaaa tcctttttat acatgtattc 2492701 gaatttgaag tgagggggaa gcttgatggc agattttgtt gctagtttga atgcggtctt 2492761 atggagtacg cccgtcattt atattttatt gggaattgga ttcgcctttt caattatgac 2492821 ccgtttttta caagtccgac atttaaaaga aatgattgtt cagatgttca aaggcaagag 2492881 ctctgaagcc ggcgtttcat ctttccaagc gttatcgatt gcgctgtccg gccgtgtggg 2492941 cacaggaaac atcgcgggag tggcgacagc aattgcattc ggcggacccg gtgcagtgtt 2493001 ctggatgtgg gcgattgcct ttatcggggc ggcgagtgcc tttgtagaat caacgcttgc 2493061 tcaaatttac aaagtgaaac aagacggtca atatcggggc ggccctgctt attatataga 2493121 aaaaggctta ggcattaagt ggtttgccgt cttatttgcc gctgctgccc ttattgcaat 2493181 ggcctttcta atgccgggcg tacagtccaa ctccattgcg gctgggatcc aaaatgcatt 2493241 cggcatctct cctttcgtca cagggtgcgg tctggtttta ttattagggt tcattatttt 2493301 tggcggcgtc aaacgaattg ccaatgcggc gcaaatgatt gttccattta tggccattgg 2493361 atatatcctg ctgtctttga ttattattgt catgaatgtg tctgaattgc ctgctgtgat 2493421 ctcattaata ttcaaaagcg ccttcgcatt ggattccgct tttggcggct tgatcggtat 2493481 ggcgatttcc tggggcgtta aacgtggcat ttactcaaac gaagccggcc agggaacagg 2493541 cccgcatccg gcagctgctg cagaggtttc tcatccggtc aagcagggac tggttcaggc 2493601 attttctgtt tatattgaca ccttgtttgt atgttccgct acagctttca tgatcttgtt 2493661 taccggcatg tacaataccc aggctgcaga tggttccttt atcgttcacc agcttaaagg 2493721 cgtagaagca ggacctggtt tcacacaagc ggcaattgac agtgttcttc ccggattcgg 2493781 tgcaggcttt gttgccatcg ctttattctt cttcgctttt acaacaatta tggcgtatta 2493841 ctacatcgca gaaacaaata tcgcctattt agcacgaggc agagaaagca aatgggcgat 2493901 gcttggctta aaactgatta ttttagccgc cacgttctat ggtactgtga aaacagcttc 2493961 acttgcttgg gcattagggg atgcagggct tggcattatg gtatggctga acgtcattgc 2494021 cattgtgctg cttgccaagc cggcgctcct tgctttaaag gattatgagc gccaaaagaa 2494081 gcagggctta gacccgatct ttgatccaaa agcgctgggt atcaaaaacg ctgatttctg 2494141 ggagaaagaa tacactcatg aaagtgaacg tgtctcctga acatactaaa accggcccga 2494201 tatgacctcg tgccggtttt ttatgaacga tagtttgtat acacttcttg aacatcatcg 2494261 tcatcttcaa ggacgtctat taatgtttcc agcttctcaa cagcctgatc atcggcttct 2494321 gcataggtat tgggaagcat ggtcacctcc gccgaagaaa ttagatattt cgattcgagg 2494381 gctgttttca cctcttcaaa atgctcaggc tctgtgaaaa cctcatatag gtcttcttca 2494441 attcgcagct cttctcctcc tgcttcaagc acatcaagca tgagctcatc ttcttctatt 2494501 tgccgttcag tacggtctat cgtaatgaac ccctttcgtt caaataaaaa ggctacacat 2494561 ccgctttctc ccagacttcc gccattttta ttaaaggctg tccgcacatt tgacgccgtt 2494621 cggtttttat tatctgttac gcattcaacc atgacggcaa tccctgaagg gccgtagcct 2494681 tcataggtga tttcttcata gctgcttccg tcttggcctc ccgcagcttt tttaatggcc 2494741 cgatctatat tttcattcgg catattggcg ccttttgctt tttcgatgac aagacgcaat 2494801 gctgaatttg cttctggatc cgctccgcct tctttcgctg ccacatagat ttcttttgcc 2494861 agcttcataa atattttccc gcgctttgca tcctgtgcat tttttctttt ttgaatgttt 2494921 ttccacttgg aatggcctgc catgttttca ccttctttta cattttctat gtacacttta 2494981 atgggaaatg ttcgctgatg caaagaaaaa ggctgccgaa tatcacttcc ggcagccctt 2495041 ccttcctagc ggttgttcat tttatgaagt tttctgaaca gccctttatc tgttgatact 2495101 tggacgtcac ggccatttgc atagttgcgc gctgctttta caacattatc tctgtcagac 2495161 tttgtgaact ctctgtggct tttgactgcg ataactactc ggtcatccga taccataact 2495221 tgtgtgtcat tgacgttttt cacttgtttc acacggttgg caatttttgc agccagtctt 2495281 ctgttttctt ggttgtcata cccgttgttc gctgcattcc gattcatgtt tcggttattc 2495341 gtgttgttat atgttccgtc agttgccaaa ggaacacgat cgtcagcagt aacacggtca 2495401 cggttattta cattcgtggt gtttcggtta ccgtcgttct gatcctccat taattcagaa 2495461 acaggaccat cgtggtcgat tccgtctccc tgtctatcgg cgtcattttc atttgtataa 2495521 tatccgattg gacgggtatt gccgttattg cgcgtatcat tcatagcatt atcgtttgct 2495581 ccgcatgctg ttaagccggc tgtcattaga atcaggctag cgatcgtcat ttttttaccc 2495641 aatggaaaaa ccccccgtgg acgaattgag catgtttgct cgcttttatc atgtgcgtat 2495701 ggggggcatg ttaagcgtgt cagttctctc catttggcag tgatctgctt gaaaacaaaa 2495761 aaaggaacga tttacatcgt tccgaacgat cactcatttt cttcttccgg acggccaaac 2495821 atttggttta cagaaggctg gttcgtcatt ggcatagaaa ctcctgccga atatgggttt 2495881 ggatttgggt tagctgtgcc atatggcata ttagggcttc cataagctcc cattcccgaa 2495941 tggccaggtg cagagaaata tggctgatga tcaccgtcac agccgcagtc gtcatgatct 2496001 ttgtatggca tgtaaccatg agccgcagca ggctggtatg ctcccattac ttggggagtg 2496061 ccgtaataag ggccatacgg catatgtcca tacggagatc cataagccgg agatgcgtat 2496121 tgcggcgcac cgtatgaacc gtaatgtccg tgatggctgt tttcatgatg ctggttttca 2496181 taacccgggt catactgagg cgatacaaag cctggctggt atccatgcat cggatgcatt 2496241 ggataagctt gtgccggata gtacggatag cataatcctg atcctggaag aattggcgaa 2496301 acaggcaccg gacacggtac gaaatgagcc ggataatgat aataaggctg aacagccggc 2496361 atcggcatat tcggaactgt gtgatgaacg ttttcctctt ctataccgcc tacctctggc 2496421 gcctttggca tattaggcat attcggataa tttgcatttt ccatattact catagcctcc 2496481 tgttgtggaa attggtcttg catatgatac atatgatcca tatttccgtc atgatgtttt 2496541 ttcggctcct ccggtttagg aggcgaccaa ggctggaaaa gctgtttcat atcataataa 2496601 tcgttcacat cagcttcagg gtacacattt tcctgcaaat taggcatcgg cgggacatac 2496661 ggcatggact tcttttcttt cggctttgtg tcttctacat cgacaacgga tttaggcttc 2496721 tctttcgcat atggatgttc ttgcttcaca ctcccggccg caggactttt gcccgctttt 2496781 ggctcttttc tgaccgggac tccttctgac ggcactttta ttttcattcc aggcatgatt 2496841 aagtctggat tgctaagctg tgtattgagt tttttcactt cctcaacatc gactccgtac 2496901 ttttcagcta ttttccagag cgaatcgcct ttttgaacga tatggatttt caacgttttc 2496961 ccctcctatg caaaacgtga acagttcagc tgtgattaca atatgtttct tcacaacata 2497021 tgcctgaaca aaagaagtta tgagtaaagg aagggaaaat atttctgatc tacgtgatcg 2497081 aaagcattcg attcagggca aggagtgcat cttcctgaat ggcttttggc accttgatga 2497141 cgcctgaagg ttctcctttt tcaatttgtt ccagcgacca caacaaatgc ggcaaatcaa 2497201 ttcggttcat tgtcaggcaa gggcacatgt cagggttgag tgattcgatt tgtttatctg 2497261 gatgctcgtg aatgatccgc tgaacaagat tcatttctgt cccgattgcc cacttgcttc 2497321 ccgccggagc ctggttgatt gtgtcgataa tatatttcgt tgatccgtta tcatcgctta 2497381 gtgtcacgac ttcgtgtgaa cattccgggt gcacaatgat ctgaatgtcg gggtctcgct 2497441 ctctcatatc atggatattt ttagtggtga atttctcgtg aacagagcaa tgccctttcc 2497501 acaaaatcac tttcacattc gtatgcccgg attcagctac taattcatct ttcatcggat 2497561 cccacacagc catatcttca agcgcaatgc ccagatcata agccgtattt ctccctaaat 2497621 gctgatcagg caaaaataaa attctttttt tctgtgtaaa cgcccattca agcacttttt 2497681 tcgcattcga agaagttaca gttgctccgc catgctttcc gacgaatgcc ttgatctccg 2497741 cagtggagtt cacataagtt aaaggtatga tcgtatctcc aaatatatgc tgaagcttct 2497801 tccatgccct attggtctgc tgcatgtcag ccatgtcagc catagaacat ccagctctca 2497861 tatctggcag gacgaccgtt tgctgctcgc ttgtcagcat atcggcggtt tctgccataa 2497921 agtgaacgcc gcaaaatacg atataatccg cttctttgtt tttttccgct acttgggcca 2497981 attgcaggga gtcgcctgtt tggtcagcaa attgtatcac ttcatccttt tgataatgat 2498041 ggcctggtat aaagagcctg ctgccgaact ttttcttaat ggcggcaacg cgcgtttcca 2498101 tatcctttct cgatagttct ttataacttt cgggcatcat atcattcgat tgtttgatca 2498161 catcaagaat tgacataaca gcattcctcc acagattcat ttgataacgt aacatccatg 2498221 ctgatatcta aacttttgac ggaatgagtc agaaatccta atgaaatata attcacaccc 2498281 gtccctttaa aagcaggcaa agattctaac gtaatcccgc cagaggcttc agtttttata 2498341 ttagccggtg tgagctttgc aaaatgacgg accgtatcag gcggacagtt gtcaaacata 2498401 ataacatccg ctccagctgc aattgcttcc cgcagctgtt cctccgtttc aatttccacc 2498461 tcgatattta ccatgtgccc tgcggcctga cgggcttttt tgcacgcctc taaaatagag 2498521 ccgcatgctg cgatatgatt atctttaatc atgatgccgt catacaaacc gaatcgatga 2498581 ttatacccgc cgccggctct gacagcatat ttctccagca ttctgagccc cggtgttgtt 2498641 tttctcgtgt cacaaatttt aatctgttca tcatccagac accgaacagc ctctcttgtc 2498701 attgtcgcaa ttcctgacag cctctgaata agatttaata cgacccgctc tcctgaaagg 2498761 agcgcagctg cgggaccgtg taactcggca atcacttcac ctttatgcaa catgtcccca 2498821 tcttttttgt gtaaaatgct ttgaacattt tcgtccaata acgaaaagcc ttcttttatg 2498881 atcgctgctc ctgcaaaaat accctctgac tttgcaacaa tctccgcttc acagctctgt 2498941 tctccaaaaa tagactgcga tgtaagatcc cctgtcccaa tatcctcaag aaaaaagtga 2499001 ttcagtaatt ttttcagctg taaatgattc attgttccaa atcccctcgt tttttctgat 2499061 cttcgttcct ttttttgtat ggacaatttg tcttccttgc cagctcacct cagcatgagg 2499121 aaaatcggtg cggaagtgag cccctctgct ttcctcccgc aaaagcgcag aaaacgtcat 2499181 cagctttgca gtttgccata gatgagaaag ttccatctgc cgaattgtga tatccttcac 2499241 atttacttcc tgaaaaggca gcgtatgaag ccagatgcta agctcaatca aactgctttg 2499301 ttcccgcaga atagacatgt ggcttgtcat tttgctttgc agttcatgcc cctctatatc 2499361 cggcacctcg tagaagacac tggtttctag ccctgattga tattgcctgt tataaaccgg 2499421 tttttggata atatgctctg ctgccctttt tccaaatacc agcgcttcca ataaagaatt 2499481 gcttgcaagc cggtttgctc catgtaaacc ggagcatgct gtctcgccaa tcgcataaag 2499541 ccccggcact gtcgtttctc cccagcgatt aactgaaaca cctcccatta agaaatgcat 2499601 tcccggagca acaggaattt ttccgctgtg gatatcaatc cctgcttttt cacaaatagc 2499661 ggtgatggta gggaaacgcg tttcaaaatc agaaatcgca ctgaagtcta tataaacgcg 2499721 atttcctttt gccatttctt cgtgaataac ccgtgagaca atatctcttg gagccaggtc 2499781 acctaaagga tgccgttcag ccataatcct gcggccgttt tcgtctacta aacatccgcc 2499841 ttcccctctg acagcttctg aaacaagccc gtaggaaaca ccatttttca caagcagtgt 2499901 cgggtgaaac tgagtaaact ccaaatccgt taattccgcc ccggcccggt aagccagaga 2499961 aagaccgtca cctgtgacag tgagatcatt cgtatggtga agaaacaggt ttccacagcc 2500021 gccggcagcc agcacaactt cgtctgcgtg ccttaccttg agccgccctt tgctgtcttt 2500081 tgtcatgacg ccgatacatc gtccgtcctc tataagcaaa tctgctgccg tttcattctc 2500141 gattaacttg attttgctgt tgatccgttt gagcaaataa tcgataagca gcctgcctgt 2500201 tgcgtctccg cctgcatgaa atatgcggtt gtatgagtgg gccccttctc ttccaagaca 2500261 aacaccgcct cgttcattgc ggtcgaatgg aaatccacgc tccaataggc tttgaaccat 2500321 catttttcca tcatgtaata cgtctgctac aatagctaga ttattatggc cgcaccctgc 2500381 gtataacgta tcctccagat gggcttcaat cgagtcatct tttgcatagg ccgcagcaat 2500441 cccgccttgt gcatagacag aattgctgtt tttgacgctt ttttttgtga taacagtcac 2500501 ttcgtatgag ggcgggaaag ctgcagctaa ggaaagtgcc gccgcccctg aaccgatgac 2500561 tgcaatcgtc tttttagaca tatgccatcc tcctgttgtt tacacctgtc ttgacaccta 2500621 tatttacaca aggataaaat aaactcaaga gttttttatg gagaacggat ggaggaagac 2500681 cggatgattt atttagatta tgcagcgaca acgcctattt gtgaggaagc ccttactgta 2500741 tatcagaagc ttagtatgga tatgtacgga aatgccagca gcctgcatga tgcaggagga 2500801 aaagcaaagc acatactgga gtactgccgt gaaaaaatcg ccaacatcat tggcggagaa 2500861 gcaagcggca tctattttac aagcggcggc actgaatcca attttctggc cattcaatca 2500921 ttgttaaacg gcctgccaaa aacgaaaaga cattttatta cgactgccat ggagcatcag 2500981 tccattcata attgcgctgc ttttttggaa cagcagggat atgatgtaac agtcattgaa 2501041 ccgaatgaat acgggcttat taccgaggaa atattactaa cccatatccg gccggaaaca 2501101 ggccttgtat ctattcagca tgcaaattct gaaaccggga tcattcagcc cattcaacac 2501161 ctgtcttcat acctgcacaa taaggggatt cttcttcatt gcgacgctgt tcaaacgttt 2501221 ggaaagatcc cgatcaatac aaaaaatctg ggagtagatg cactctcaat gtccagccat 2501281 aaaatccacg gtcctaaagg agtaggggcg gtctatatcc ggccggatgt cccttggaaa 2501341 cccgtttatc ctctgactac tcacgaatac ggattcagag ccggcaccgt aaatgttccc 2501401 gggatcggtg ccttcactgc cgctgcagaa ttgatcgtaa gcgaaatgga aaaacagata 2501461 tcccgcaatg aggcattaag aacatacttt ctagaccaaa tccgtattcg gtctctccct 2501521 gtaacccttg cagcagacac ttcgaaagca gaatgtcttc cgcatattat agggtgtttt 2501581 tttcactcat ttgaaggaca atatgttatg ttagaatgta atcggagtaa tatttgcatt 2501641 tcaaccggca gcgcttgttc tgcaggttac cacggtccgt ctgaaacaat gaaagcatta 2501701 agaaaaaccg aacaagaagc tctgcaattt atccgcatct cttttggcag gcatacaaca 2501761 gctgaacagc tggaacagtt attacatacg tttacagtgc tttgggaaca aaagaaagga 2501821 gaatttgata ttgaccgaag aattaaagct aatgggcgcc aacaggcgtg accagcttct 2501881 tctgtggctg aaggaatcta aatcaccgct gacaggagga gaactcgcaa aaaaagcgaa 2501941 cgtctcaaga caggttattg tacaggatat atcgctcttg aaagcgaaaa atgtaccgat 2502001 tatcgccaca agccaaggat atgtatacat ggatgcagcc gctcagcagc accagcaggc 2502061 agaaagaatc atagcatgtc tgcacggtcc tgaacggaca gaagaggaac tgcagctcat 2502121 cgtcgacgaa ggcgttacag taaaagacgt aaaaatcgag catcccgtat acggagattt 2502181 aactgcagcc atccaagtag gcacccggaa agaagttagc catttcatca aaaaaatcaa 2502241 ttctacgaat gctgcctact tatcacagct gaccgacggc gtgcacctgc atacactgac 2502301 agcacctgat gaacatcgca tcgatcaagc ctgccaagcc ctcgaagaag ccggcatttt 2502361 aattaaagac taaaaaaagc cctctagtgg gcttttttta taattggtaa gactggtatg 2502421 cacccagaag cctcactttg cagccgagtg cttcaagctc ctgcatggcc cctggaatca 2502481 atacatcatc aaacgctttc tcaatatcaa taataaagaa ataatggcct aatccggttt 2502541 tagtcggacg tgactcaatt tttgacaggt ttaaatttct ccaagaaaat gcagacagca 2502601 ctctatgcag cgccccggac tgatcatcct gcggcagcat gaccattaag gtcgttttgg 2502661 gcctagagct caattttgaa ttcacttcaa aagatatgtt ttcatcggga gacaggataa 2502721 caaatcttgt atgattgtcc ctataatcct gtatatcccg tttcacgatt tttaattcgt 2502781 atgtagaagc tgccatatca ttggcaatga ccccgatatt cagctcggga tggtcactga 2502841 caaactttgc tgccgccccg gtagaattgg cgtattcata tggaacggaa ggaaaatgtc 2502901 gatgaagaaa tttatggcat tgcgcaatcg cgtgtgaatg tgagtaaatt ttgtcgagct 2502961 ctttccatgc attctctctt gagggatgga cgagcaagtg ctggtgaatc ggcaacgtca 2503021 tttcacccac gattggcaaa ggctgttcat gtattaaata gtctattgtt agattaacag 2503081 atccttctaa agcattttcc aaaggaacaa aagcaaaatc aacttcgcct gcaacggctg 2503141 catctataca ctccggaatg gtgcggtaag caacatgttc ggcgccgttt tgaaaacaag 2503201 aactgactgc tagatgtgta aatgtagctg ctggacctaa ataaccgact ttcatgacga 2503261 ttttctctcc cttatgcacc tgaacctaat atttcaacct tttctacaaa atcaaacttc 2503321 ctgagcttat tcattaatgt atgaatgtct tcttccattg ccgacgtact gatagacagt 2503381 gtcacatttg ctctgccttg aagcggaatg gtctggtgaa tggaaagaac gttgcttcca 2503441 gaatcagcta ccgcctgaag aagctgagat aacgcacctg acctatcctc caaatgaaag 2503501 aaaagtgtga taatttgttc ttttaccatg gtgtagaatg gaaaaacagc atccctgtat 2503561 ttataaaacg cacttctact taaatcgacc ttttgaacgg catctgctac tgaatctgct 2503621 ttttttcgat caagcagctt tttgacttct aatgtttttc tcattgcatc gggcaataca 2503681 tcttcacgga caagataaaa tgtctcctct ttcatttgca tccccccttt aaaatagaga 2503741 gcctggcacc aggctctctt ttcagccaac attgattaat caataaattc aaattcaaat 2503801 tccagaagcc tgattatatc tccatccttg gctccgcgtt ctctgagtgc ttcatcaaca 2503861 cccattccgc gcatctgtct tgcaaaccgt ttaaccgatt catcacgtga gaaatcagtc 2503921 atcttgaata accgctcaag gctgtctcct gaaagcacaa atacaccgtc tggatcgcgt 2503981 gtaatgttaa atggcacttc ttcattttcc atcgtgtaca tgacacggtt ttgtgtaagc 2504041 tcttcctcgt catacagcgg gaattccggt gtgttctcaa gctgattggc aacctcaaac 2504101 agaagctcac gcagaccttc tcttgtcacc gcactgatcg ggaataccgg ataatcatcc 2504161 gtcagctttt ctttaaaggc ttcgagattt tccgcagcct ccggcatgtc cattttattt 2504221 gcaacgataa tttgcggacg ctcagtgaga cgcagattgt actcgctcag ctcctggtta 2504281 atcgtaagat aatcatcata tggatcacgg ccttctaagc ctgacatgtc aatgacatga 2504341 acaataaccc tcgtccgttc aatatggcgc aaaaactggt ggcccagtcc gacgccttgg 2504401 tgtgcgcctt caatcagccc tggcaaatca gccatgacaa agctgcgtcc gtcatccgtt 2504461 tcaaccatgc cgagattcgg gacaagcgtt gtaaagtgat agtccgcaat tttcggtttt 2504521 gcagatgaga caacagacag caaagtagat tttcccacac tcgggaaccc gacaagtccg 2504581 acatctgcaa gcacttttaa ttcaagaaca atgtagcgtt cttttcccgg ctcgccgttt 2504641 tctgaaagct gaggcgcggg attagccggt gtagcaaagc ggctatttcc tcttccgcct 2504701 cttccgcctc ttgcaatgac agcccgctgt ccgtgctctg ttaaatcagc gatgacctgt 2504761 tttgtatcat cgtctgtcac aacggtgccc ggcggaactt taatgaccat atcatcagca 2504821 tttcgcccgt gctggttttt ggacatgcca tgctcgccgc gaatcgcttt aaagtgtttt 2504881 ttgtatctaa aatccatcag ggtgcggaga ccttcatcta cttcaaaaac gacgtctcct 2504941 ccctttcctc cgtcaccgcc ggcagggccg cctttcggca catatttttc acggcgaaac 2505001 gcaaccatac cgttgccgcc gtcgccgcct tttacatata ctttgacctg atctacaaac 2505061 ataatgtcct ccgttctaaa ccgttaaaaa ctccgctagt ccaacccaat ttcaatcaga 2505121 cattcgtgac tcgtgatttc aaaacgcatg atatcaacgt cctcatatcc attctgccga 2505181 atatcatcaa aagcagatgg atcggcaaag gcgccgtgaa aatcaaggta cagaatcagc 2505241 tgtctgtcag gatgatccgt ttgaagcgaa accgttaaat gattttcact ctctctgctg 2505301 actgcttgat caaacagatg aaacagcttt ctcatcagtt tcgccagctt ttgatcataa 2505361 gccgacaaat ccttaatttc tccgagaact tcatattcaa gcgtcatata atgggttttc 2505421 caattaaacg taagaaaatc aaacgccaaa tgcggtgttt tcaggtttga gagctttgat 2505481 tcgtgctttg cgtctataac catttcttca atcatttcaa agacacggtc atacttctgt 2505541 aagcttaagt ttcctttaat cagctgcagc ttattcatcc aatcatgccg ggaatggcca 2505601 agcagatgaa tcagttcgtt tgttaatgcc gtgtcgctta tattttcttc ttgatttttt 2505661 gaaacatcct tcattttcgc actcccaatc atttaatttc ttatttagga gtctgtataa 2505721 gtgtgtatta tgaattataa cagagaaggc tttgttagaa aaacaattgt ttttcccaga 2505781 aatatcatgt tccttttttc tggctttggt tgatttgcag ccaggcagaa cattttatgt 2505841 attactgctt ggggaacata tccagtgggt ttgagatgtt tattctcatt cttggcgggg 2505901 tctgctcgca catactctgc atttcattct aggtgtttac tccgcatatt gcaaaaaaaa 2505961 ctccagtcat catcgaccgg agttttttga atcattattg agctacagga tatacgctca 2506021 cttttttgcg gtcacggccg aaacgttcga atttaacagt tccgtcgatt ttcgcaaata 2506081 gagtgtcatc tccgccgcgg cccacgtttt cacctgggta aatttttgtt ccgcgttgac 2506141 ggtaaaggat agaaccgcct gttacgaatt gaccgtcagc acgtttagca cctaaacgtt 2506201 tagcctcaga gtcacgtccg ttctttgtag aacctactcc ttttttagaa gcgaaaaact 2506261 gaagatctaa tctaagcatg tagctcacct cctatattat gtttgtggtc acacgcaagt 2506321 tgtctttgta atcccgttcg attgtctcca gcgaaacaat catgccttca atcagcagct 2506381 gagctttttg gcgtgcctct ggatcaagag attcagggaa ttcaaaataa aaataacccc 2506441 cgtcctctcc tatatcaaga agcggctcga agcccgcgag cacaatgacc gcgttaacgg 2506501 ccccaaacac aacggctgtc actccggcac aaacaagatc ttgtccatgt tcagcaaaat 2506561 tcgcatggcc cgtcatttca aaagacaata tgcctttatc atgagacctt ctgattgttg 2506621 cctgaatcat gcttacgcgt tgattttttc gatcgtcact ttagtgtaag gctgacgatg 2506681 accttgtttt ttatgaacgt ttttctttgg tttgtatctg aaaacagtga tttttttcgc 2506741 gcggccttgt ttttcaactt tagccgttac tgttgcgcct tcaactgtag ggttgccgac 2506801 tttcacgttg tctccgccaa caaacaaaac gtcttcaaaa gtaactgttt cacctgcttc 2506861 agcagcaagt ttttcgatgt aaacagtttg gccttcttca actttgattt gtttaccgcc 2506921 tgttttaatg attgcgtaca ttctctgcac ctcctattag actaagactc gccagatacc 2506981 agggggctgt aaaagctctt aacacctgta ctgagcggtt gtagcaatgg tgctacatcc 2507041 ataacattaa aaaatatacc aaaatacaag gcgtttgtca atcagtttta gtagggcaga 2507101 agcagttcct ccatggaaga attcgtccgc ttatcggcaa agtaagcgtg cagcacttca 2507161 ttctcgtcaa gctggctgag cttttggcct gatttttcta taataatcgg atgcttacag 2507221 ccacgtttga actcggccat cacatgatag actttatcct ccgcctttac tgtcagcggc 2507281 agaagtttct caagctccct gttttttccg taataccttt cgaggagaaa tctcacatgg 2507341 atatagtgcc tttgccgata ttcctcaaac aaggaaacag ccagaaagac aaacaaaacc 2507401 catgcgctga tttgcagagg aatcacgaat aaaacccagc acccgagcag caggcagaag 2507461 cagagcgacg tttttagatt aagccggtga gccttttgaa aaggcagctg tttggaaaac 2507521 aacaaaaata acagttttcc tccatccagc ggccagatcg gcagtaaatt gacaaataag 2507581 atagaaagat tataaaaggt gaagagttca aaggtatgct gatgaatcac tgagacttct 2507641 gcaagcatcc aggcggcaaa ctgaagccag atgtgctgaa gaggtccggc aataatgacc 2507701 gcaaactctt cctttaacgg ccgattcccg tgctcttcca cttcgaccgt tccgccaaac 2507761 ggcagcaaaa aaacacgctt gattctccaa gaaaaaaaca cagccagagc agcatgcccc 2507821 agctcatgaa tcaatacaat caggagcaga cataataatg ctttcatatg gcctgtgagc 2507881 aagcccagcg ccgcaataat ccaaagaaaa ggatgcacat ggatctttaa gataaggtcg 2507941 agccatttat tcaaatgaaa tcacctgaat cggatcaata aatttatcgc cgtctttcat 2508001 ggcaaaataa tagacccctt tattatgatc atcaagctta atcgaaccga gctttttgcc 2508061 tttatccaca aaatcatata aagcaacatc cacatctttg agctcgccat agatactata 2508121 ggtgttgtca gcatgctgca ccttaaccgt cagtcccgtt tggctgtctt tgctgacttc 2508181 aaccacatag ccttctttta cgctatcaat cttatcactg cttgtttcga ctttaattcc 2508241 ttccccattg tcctgaaaat cctgctgtac tttcccggat gcaggcgcga tcagatcttt 2508301 gcctacttca atctgctgtt ccttattttt gtgttcagga gccaggaaag caagcggatt 2508361 tccgaatttg gtttcgaacc aatggcttgc tgaagcaaat tgaaattcag tttcaaaggt 2508421 tttggctacg gcgggtttaa tctgactgac gggtccaatg tttgttttat aggctatagc 2508481 tgaaacgaga acaaggcagg ccgacagaag acatttcagg ataattgaat ctgttttcac 2508541 caatgggtgt tttccgttga atgttggcat gttatcttcg tagaccggaa gtgttccatg 2508601 cttttcctga tccgttacca tcacccagga cgggggtttc tgcttttcag aaactgtctg 2508661 agtagagaaa cgttttgagc cggaaagctg ctttcttctt ttctctaatc gttttctgat 2508721 ttcatctgct ctgtgactca ttgccatcat cctttgcatt cgttgggttt gtacatcata 2508781 tgtcttgtcc atggcaaata ttcggtttag tcaagaacaa agcaggcaaa aacaaaaaaa 2508841 acctgacaca gcatatgctt tgtcagattc ttctctttga ttctatcaca ttaagatctt 2508901 actccgaaaa atgacttaat cttagccatc attcctttgt tttgctcttc aagcacctgt 2508961 aaaggaacag attcacctaa gatgcggcgg gcaatattgc gatatgcaat ggaagcgcgg 2509021 tttttagggt ccatcgcaat cggttcgcca tgattggaag ctttaatgac ttcatcatca 2509081 tcagccacga ttccgagcaa atcgatcgac agatgctgta cgatttcgtc gatatccatc 2509141 gtgtcaccgt ttttcatcag gtgatttctg attctgttaa caacgagccg cggcggttca 2509201 atattttcct cttgctccag cagtcctata atacggtcag catcacgaac agctgagatt 2509261 tcaggcgtag tgaccacaat cgctttatca gctccggaaa cggcattttt gtacccttgc 2509321 tcgattccgg caggacagtc tatgatgaca tagtcaaatt cctgtttgag ctcttggacc 2509381 atgtttttaa tttgttcagg agcaacagct gtcttatcgc tcgtttgagc agcgggcatt 2509441 aaatagagca gatcatcgaa acgtttgtct tttacgagcg cctgatgcat tttgcatctg 2509501 ccctctacaa cgtctaccag atcgtaaata attctatttt caagacccat tacaacatca 2509561 aggttgcgca gtcctatatc agtatctact aagcatacgc gcttccctaa aatggctaag 2509621 gcggtaccga ggttcgcaga tgttgttgtc ttacctactc cgccttttcc cgaagttatt 2509681 acgatagcct cacccaattc acattcctcc ctcaagcctt gttagatcag gtcttaaatg 2509741 agccaaatgt tgaaggcgtt caatgaccat atttccgtct gtatctaaat aagcacattc 2509801 catttcgttc cctttttgaa tgtggtctgg ggagcgattt aacacatgat tgattcttaa 2509861 ttgtgtcgga agcatttcag aggcggcgat gaccgcttga ttatttccat tgaatccagc 2509921 atgcgcaatt cctttcagtg agcccagaac aaaaatgttc cctccggccc tgactgttcc 2509981 gccgggattc acgtcaccga tcaggagcaa gtcgcctttt acctgcagca cttggcctga 2510041 acggacaatt tttgaaacag aaataatttc ggcttcctct cttatctgct gtgcttcttt 2510101 tttagtaatg acttcactgt caatagaatg aacaaacaaa tctttctttg acgcaatcaa 2510161 ttcggttagc tgttcctctt gctccttata taaaaagcga tttcccagct taacatgaac 2510221 gctgattttc tggccttttc catcggtata ttgttcaatt gacagcatat tctgaagacc 2510281 atcgagaagc tcatcaaaag aacacgcatc atccagatgc aatgttagtc cattctttgt 2510341 tccttttatt gttacatatt gctgcttttt ggtcttcaca atattcacct caacaacata 2510401 ctcatttcgt caaaaaaaga taaaatcctt tttactcatc tctcaattct ttctttagac 2510461 tcataaaaaa caatctaaat ggcagaacaa gaataagagc tgctgcaata tttaataaaa 2510521 ttgtcggtat aaaccggtca agcacaaatc cgttaaacgt cataatgtct ttatgaatca 2510581 aagactgaat gccgaatacg taaaattcga gcagacagac agccagaact gctatcaata 2510641 tcactacaaa tgcgtttgta tgcaacactt taaacgcttt tgaagccaaa tagcatagcc 2510701 ctgcaaaacc aaacatgtaa acgcctaata gacttgtata gttcatgtca tatagaaagc 2510761 caaaaataaa tccgtaaatc atcgcgtgtt tttggttgat aaaagccgac atgaatatca 2510821 atacaagcat caaaaaacgc ggggcgagca cttggtcatc tgtaacgaaa ggaaaatgca 2510881 ccaaatctgt aaaaatgctt tccgcagaaa aaacaagcat cataacgaaa gggagaagga 2510941 aacgtttcac gatccttcct cctctgtatc gacagtcggc acgtcacggt taacaacgat 2511001 cacattattt aaatctgtaa ggtcagccgc aggttttaca taagcaacct tcgttaatcc 2511061 ataggaatct gactcgatat cagtcacttc accgattgtc agcccttctg ggaaaacacc 2511121 gcctgtccct gatgtttcaa taagatcgcc ttttttcacg tcttgtttat ccttacgctc 2511181 aataattgtc atcttaagac gttttttctc tttgtcatat ccttcgatca agccgtagcc 2511241 tttgctgcct ttttttccgg aaatttttgt cgcgactctg ttattgcggt cagtatcgct 2511301 taaaagctga acagcagacg taaaattgtt aagtccggag cttttgatct tgccgattaa 2511361 tgcgcctttt tcgtttgtaa cggccatatc tttcgctacg ttttgctgag tccccttgtt 2511421 aatggtgacc tgtttcgccc aattatcagg gcttctggcg atgaccgttg ctaaaatcgg 2511481 cttgtaatct ttaatcgatt tgacatggcc aagctcgtca cgcaaggatt tgttttcttc 2511541 ttcaagctct tgaagcttgg cttcatattg tgtctgtccg tcaagttttt ctcttagacg 2511601 ctcgttttct ttgtatgtgt tttttaaatc attgatgttc tcaaatattc ctgcaaaaaa 2511661 ttcggcaggc gtatgaaaaa tattttgaaa tactcccgtc gtatcgccga tcactttctc 2511721 aggccaggtg gtattgcggc cgcccttcag cgaaaatcca atcatagcca ccaatatgat 2511781 aatacacaga agtaatagca ttaaccgctt attcggcatc gtgttacacc tcttctattg 2511841 aactcccgat tatctagttt tccctttgaa aagatggatg tgctccagtg ctttccctgt 2511901 tccgatcgct acacaatcaa gcggatcttc ggcgataagg accggcattt ttgtttcttc 2511961 gctgatgact ttgtccaaat tgcgcaaaag cgctccgccg ccggttaaca ctatacctct 2512021 gtccatgata tctgctgcaa gctcaggcgg tgttttttcg agtgtgctct tcactgcttc 2512081 gacaattgta gatacagtgt cgcgtagagc gttagaaatc tcttttcctg taatttcaat 2512141 tgttttcggc aaacctgtga gcaaatcgcg gccgcggatt tccatgttgt cggattcttc 2512201 aggagcttct gcagatccga tttccatttt aatcgcttca gccgtacggt caccgatcat 2512261 cagattgtac gtttttctga tgtagttgat aatcgcgtca tccatctcat caccggctac 2512321 acggattgac tgagacgtta cgatgcctcc gagggaaata atcgcaactt ctgtcgtacc 2512381 gcccccgata tcaacaacca tgcttccagt cggttcccaa actggcagat tggctccgat 2512441 tgctgcggca aaaggctctt caatcggata cgcgtcacgc gctcccgcct gtcttgtcgc 2512501 atcgataaca gcgcgttctt caacagctgt aatgcctgat gggacacata ccattacata 2512561 tggttttctg gcaaacatgc ctttattttt tatggcctga ttgatgtaat atttcatcat 2512621 cgtcgccgtt gtttcataat cagcgataac gccgtctttc atcgggcgaa gagccaccac 2512681 gttgcccggt gtccgtccaa tcatattttt cgcatcattt ccgacagcga caatcgattt 2512741 cgtatccgtc tgcaaagcga caactgacgg ctctctcaca acaattcctt ttccttttac 2512801 aaaaacaagc gtattcgcag ttccaagatc tataccaagg tctctagcac caattccaaa 2512861 catatgtatg tatcttcctt tcttaaagca aaaataccct aaagggaaaa actcataaac 2512921 tctattatag cttaattcga cgaaaaaaaa agtgttacaa atatcctttt tcctttaaac 2512981 tcacaaattt tttatccccg atcaccaaat ggtcaagcag ctcgatgcca atcaggtttc 2513041 cgcattcaaa cagccgtctt gtcacttcaa tatcttccct gctcggcgtc ggatctccag 2513101 aaggatgatt atgaacacag ataaaggaag cggcagatcg tttaaacgct tctttaaaca 2513161 cctctcgcgg gtggacaata gatgaattca ggcttccgat aaatacggtg cgtttatgga 2513221 tgacttgatt ttttgtattt aagtataaac agacaaaatg ctcctgggtt aaaaagcgca 2513281 tatcctccat gacaagatta gcgccgtctt ccggggagcg aataacgaaa tgttcttcgt 2513341 tggctaattt atgaatccgg cttccaagct caactgctgc cagtatttga atcgctttta 2513401 ccataccgat tcccgggatg cttgacagct cttcaaccga tgcttccttg agcaggcgca 2513461 gcccgtcaaa tgagcgcagc agccggtttg acaggtccaa aacagattcg tgtttagtcc 2513521 ctgtccgcaa taatatagcc aaaagttcat gattcgctaa gttctcggct ccgactttca 2513581 ggagccgttc ccttggcttt tctttcattg ggaaatcttt gagttttaat ggcagatcgt 2513641 gtatgaccaa gcactccttt tctttccctt cccgtttata gaaccgtcat gcccttatat 2513701 caaaatggcg aagagctctc attgtttttg atataggaag gcccatgact gaataataat 2513761 ctccgtctat tttctttaca aaaagcgcgc ctcttccttg gatgccgtat gcacctgctt 2513821 tatccatcgg ctcttttgtt tcaatatatg tccaaatctc ttcttcactg agggaccaaa 2513881 acgcaacttc tgtcttatca taaaaagtct cgctgtgatt ttcagcttga atgctgaccg 2513941 cggttattac tgagtgactt cggcctgaaa gcctccgcag catagaagca gcttcttctt 2514001 gatcctgcgg tttgccaaga cattcgccgt caaggcatac cattgtatca gcaccgataa 2514061 cgattgcatg cgggtggaga tcagctacag ccttagcttt ttgttttgcc aaccattgga 2514121 cgttttcttc tggtgaaaag tttcgattta atttttcttc tacttcactg acaataatgg 2514181 agtagggcag ctggagaaga tcgaggagtt ctttcctgcg cggagattgt gatgcaagta 2514241 ttagcggttt tgtcatgttc gtcatccttt cagggtttgc ttaagaaaaa aagatactcg 2514301 tttatcctac caaatcacga ggcttgtcac aatttcagaa aaataacttt ttcatgacaa 2514361 aataaaaaaa gcctgtcact aaaggacgaa ggctcagggc actatctctt attttacgac 2514421 ggctaacagc tcctgctgag ccttccaccc ggcttcagca cttggatcct ctaattcctt 2514481 taaagcctgc aaaatcgctt ttttctctcc tgtttctgac gcttttgttt caccaagcga 2514541 cttttctatt ttctctacac tcgcttttgt aatgtcttcg tcgagaatcg cctttgctgc 2514601 aagctccgct gtttccttaa aagaatctgt catatctgac tctattgata aggaaagctc 2514661 cttgcctccc caggcttcaa aatcactgtc gattaaaacc tgtcctaact gctgtgagac 2514721 ctccttttca cttgctaagc ctgcaataac atacgtatac ccgtcatcct ttgacagtga 2514781 cacggcggaa tatccttttt cggtcaattg ttctgttaac gtttcggcgc ccttttcatt 2514841 tgaaaatttt ccggcttgca cagcgtatgt tttgtatgta ccttcagttt gtgccgcttg 2514901 tttttctgcg cctgaggttt gtttatcagc agaagtatcc cctgcttttg ccgtttggct 2514961 gcctaaagaa tcctctaaag aggccggtgc tgacgcttct ttattccccg atatgtttaa 2515021 cgcgaataac cctaatccag tgccaatgac agccgcgaag gcaatcgtcg cggccactct 2515081 ttttaccggt ttggcagccc cggtctttcc ttttgcgtaa agctttgttt ttttcttttg 2515141 aaaaggagga acaactttag ggtcctcttt aaacaccttg tcctcctcgg aatcccaatt 2515201 gaattcatct tcatcagggt gttcctggga tgccgcaacc tcttgttctg cctgtctttt 2515261 ttcctcccaa tttgaaaatg tcatgctttt attcgcctct gtctcaggcg tctcttgttc 2515321 gtaaaccgtc tcttcttttc cattaatcgt caccttgagg gctttttctg cggctttact 2515381 gtttttttta ttctttcttt ttttcaattc cgcttcctcc cttcatttgc ttgaccgttc 2515441 ttgtcggctt ttcatgctac acactttagc acaggcaaag aaaaaaagaa caagactttt 2515501 gtcgccttgt ccaaaaaacg ttcgtcaaat ttttcagcag tcagcccaat gccattttga 2515561 tataaaaaga aatgatagag tcaccgtata aataggctaa aatgctccct gcggctatag 2515621 cgggggcgaa gggaagcggc tgccttttag cgagtctacc agtcagaaca gctgccgctc 2515681 catataatgc acctatcaaa actgaaaaga aaaaggcagc tgccagcatt ttcacaccaa 2515741 gcacaaagcc aatcaccgca aataatttaa tatctcctcc ccctactccc ccatgggtga 2515801 ttgcggcaat tacagccaga aacaaaaatc cggctgccgc acctaacagg cctgcatacc 2515861 aggaatcaag cggagaaatc aatctcgcgg ccgccaaaaa gggaagaaag aaaatcaata 2515921 ttcgatttgg aatcagcata aaatgaatat ctgtcactgc aacaataatg agaagagaga 2515981 taaacaccac agcgggaaac agttccagcg atatgccaaa gcgtattcct gcggcggcaa 2516041 ataaacacgc tgtcacaagc tctgctgcgg gatacataaa agaaatccta tgcccgcagc 2516101 ttttacattt acctttttga aataggaatg acaggatggg aattaattct gcaggagtta 2516161 atgttcgccg gcaaaacggg catgatgaac ggggcgcaat aatagataga tgtaagggga 2516221 tacggcaccc ggccgtatag taaaaagaac caaggataag cccgaagata aaaagaatgg 2516281 atagcataga caacacacct ttactcattg agttctggta tggattgtag caaaatggac 2516341 atcctgagct ccaattggga atattcaatt ttacacatga aaaaaacggc agaatctttt 2516401 tttgattctg ccggagccgg atgcttttat ttcaaccttt ttcgaatgtc agaaataaag 2516461 taaagagatc cggtaatcag cacaatttca tttgagccct ttttactttc tatgaatttg 2516521 attacatcgt ctggatcttc actccagctt ttattgctga tttcacttgc atcatagaga 2516581 tcttttgcaa gggaagcacg cgggaaatca aaagaagcaa aatgaatcgc atgagcaatg 2516641 gtttccagtc ttttaatcat gttctgatac ggtttgtcct ttaacgcgct aaacaccaca 2516701 gaaatgcgtg aattggcgaa acgctgcttc atcgtttccg ccagcttttc aacaccttct 2516761 tcgttatgcg caccgtctaa atataccgga ggatgttcct gaacaagctc taaccgtccc 2516821 ggccaagcag ccttcacaag cccgctcctt aacgcttcgt cactgatatg ggcgatattc 2516881 tccttattga gccactccgc agccaaaatg gacaaagcag cattttgtct ttgatgggtg 2516941 ccaatcagag atgtccgaat atcttcatag catttctctt ccgttttgaa tgaaaactgt 2517001 tctcctgcag gcagagcctc ttcattgaaa ataacacatg catcatgcaa tgactggaac 2517061 ggcgcagcat gccgttcggc ttcatggcgg atgacctgta aagcttccgg ctgggtaact 2517121 gctgtaacga ttggaatacc ttctttaata atgccggcct tttctcctgc aatttcttca 2517181 atggtgtttc ccaaaatgtt catatgatcg tgtccgatgc ttgtaatcac agttaagagc 2517241 ggttcaacca cattagtaga atcgaatcta ccgcccagac ctgtttcaaa aataacaaaa 2517301 tcgaccttat gaaactctgc aaaatataaa aatgcacaag ctgtcataat ttcaaattct 2517361 gtcggctgtc cgtattccgt ttgatcaagg gcttcaacgt gcggtttcat ttgattgacg 2517421 agtgctgtcc attcctcatc tgaaatcggt atcccgttta cgctgatccg ttcattaaac 2517481 gtaataatat aaggcgatgt aaatgttcca accgtatatc cggcttcctg cagcatagaa 2517541 cggataaaag cgacagttga tcctttaccg tttgttcctg cgacgtggaa cgctcggatt 2517601 tttttttcag gatgtcctaa ccgcgccatc agctgtttca ttcgaccaag tccgggcttc 2517661 accccgaatt tcagcctccc gtgaatccag ctgcgcgcat cttgatatgc agtaaacaat 2517721 gataatcccc tcttttataa gacaaggcgg tttctctaga aaccgccccg gcttttcatt 2517781 aacccttcag ctcagccatt cgtttttgaa cagcgtcacg cttcgccaca taatcttttt 2517841 ctttttcacg ttcttcatca attacgtgtg caggcgcttt tttcataaat ccttcatttc 2517901 caagtttctt ttggacacgc tcaacttctt ttgtcagttt atcaaattct ttttgcagac 2517961 gggcaatttc ttcatcaata ttgattaagc cttcaagcgg aagaataacc tctgctcctg 2518021 agacaacggc cgtcatcgcc ttatcaacag cctcaatatc ggtgccgatt ttaagcacgc 2518081 tcggattcgt aaagcgttca acatatgaac ggttcgcttc gaggcgggac gctatttcgt 2518141 ctgtgcttgt tttaatgtac agttcaacct gcttgctcat tggcgtattg acttcactgc 2518201 ggatattgcg cacagaacgg atcagctcaa caagaagctt catgtcagct gccgcttcag 2518261 tatcggtatg ctccggcact actgcaggcc attgacttac tgtaatcgat tccccttggt 2518321 gaggaaggtg ctgccaaatt tcctccgtta agaatggcat aaacggatgg agcagacgca 2518381 tcgtttgatc aagtacgtaa gcaaggatgg aacgggtagt tttcttagcc gcttcgtctt 2518441 ctccataaag cggaagcttc gccatttcaa tataccaatc acagaaatca tcccaaataa 2518501 agttatataa atggcgtcct acttcaccaa attcatatcg gtcagcaagc tgggtcacgt 2518561 gctcgatcgt ttcatttaat cgcgttaaaa tccacttgtc agcgactgac ttttcacctg 2518621 acagatcaag ctcatcgtac gtcatgccat ccatattcat taatgcaaaa cgggaggcgt 2518681 tccaaatttt attggcaaaa ttccaggtcg attccacttt ttcatagctg aagcgcagat 2518741 cctggccagg agagcttcca gtcgcaagga aataacgcag agaatcggct ccgtacttgt 2518801 caatcacatc catcgggtcg acaccgttgc caagagattt actcattttc cggccttgct 2518861 cgtcacggat taagccgtgg attaaaacat ctttgaacgg gcgctcgcct gtaaattcaa 2518921 tgccttggaa aatcatgcgt gatacccaga agaaaatgat atcgtaccct gtcacgagaa 2518981 catctgtcgg atagtagcgt ttaaagtctt cagccgttac atcaggccag cccattgtgg 2519041 agaaaggcca tagcgcagaa ctgaaccatg tatccagtac gtctgtatcc tgttcccaat 2519101 tttcgctgtc ttccggcgct tcaagtccga catatagctc gcctgtttct ttatgatacc 2519161 aggcaggaat acgatggccc caccacaatt gacgggagat acaccagtcg cggatatttt 2519221 ccatccagtg taaatacgtt ttttcgaaac ggtcaggcac aaagttgacc ttttcttctt 2519281 ttttttgcag ctcaatcgct gcatcagcaa gcggctgcat gcgcacaaac cattgtgtag 2519341 aaagataagg ctccacaaca gccccgcttc gttcactatg gccgacagag tgcatatgat 2519401 cctcgatctt gaagagaact cccgcctcct gtaaatcttt cacgagcttt ttgcggcatt 2519461 caaaacgatc cataccttga tattggagcg cattttcatt catcgtgcca tcttcattca 2519521 tgacaaggat gcgttctaaa ttgtggcggt tgccaagctc gaagtcgttc ggatcatgag 2519581 caggcgtaat tttcacggca cctgaaccaa attccatatc aacatagtca tcaccgacaa 2519641 tcggaatttc acgatttaca atcggcagga tcaccgtttt tccgataagg tgtttatagc 2519701 gctcgtcttc agggtgaacg gcaacagctg tatcaccgag cattgtttca ggacgtgtcg 2519761 tcgcaatttc aattgagcct gaaccgtcag caagcggata gctcatatga tagaatgcgc 2519821 cttgaacatc cttgtaaatc acctcaatgt cggatagggc tgtttttgtc gctgggtccc 2519881 agttaataat atattcgcct ctgtagatca ggcctttttc ataaagctta acgaatactt 2519941 cccttaccgc tttgctcaag ccttcatcca gcgtaaaacg ttcacgggaa taatctaggc 2520001 caagacctaa tttcgcccac tggctgcgaa taaagtcagc atattcttcc ttccacttcc 2520061 acgtttcttc gaggaatttt tcacggccta aatcgtagcg ggatttgcct tcttcacgaa 2520121 gtttcgcctc cactttagcc tgtgtcgcga tgccggcgtg gtccatgcca ggaagccaca 2520181 gcacatcata gccctgcatg cgtttcattc ttgttacaat gtcttgcagc gttgtgtccc 2520241 atgcgtggcc aaggtgaagt ctccctgtta cgtttggcgg cgggatgaca acagagtatg 2520301 gctcttttgt ctggtcactg cccgcttcaa aaaatttgcc ttttagccaa aaatcatatc 2520361 ggtctttttc aaccgctgcc ggatcatatt tcgtcggcat tgtttgttca ttcgtttcca 2520421 tcataaccct ccagcatgtt taaaaatggc tgagaacgaa aaaagagctc ttcatccctg 2520481 taaaaggacg aaaagctctt tcgcggtacc accttttttc atgaactcaa tcagttcatg 2520541 cacttataac ggataacggg tgtttcccga atttctctac tcttctttca agaaattatg 2520601 ctcccgggcg accttccaat cagacaacat aagaagcctt tcagcaaacg gcttctctct 2520661 ctgcatgcgc cttttttgta ctcttcccgt tctaagcagg tgtatttatc agctcattgt 2520721 atacattatt tatgttcttt attatagtaa aagtgttttt gattcgtcaa tcatcttttc 2520781 caaaaacacc gctttctata cagatgggca ggcacctatt gcccaagttt acatatgatg 2520841 cttgtaaatg cgtagaggag gatgcaccgt gaagaaacgt ttcagctctt attcgctgcc 2520901 gccatgggta aggcaaattc ggcttgtatc cgcacaagtg attattccca ttacgatttt 2520961 tcaaggaatc agaaccattt tctttccgac aacctttgat gttttgctgc tcgcaatcct 2521021 aatcttttta gcttgcgccc ttcatttaga atggatataa acaaacaagt ccgcgccatt 2521081 aagacgtgga ctcgttttca gcctgaaatt ttttctcttg ttcaatctga tgaattttca 2521141 tcacaaacgg ctctatgttt ttcatttgcc aataagcctt taataattgt gtacattcct 2521201 ctttttcatg ctgtcttttc ccagtttgat aaccgttcag caccttgtac atggctgccg 2521261 gatatgccat atagctgaga aaaaggctga cttccgcttc acgcaaaggg aatgatttcg 2521321 tatatccata aaaccattcg acgcattccg gacaagcttt cggaaagcct ctgaacattt 2521381 ttgtataaaa gccgagcagg tcgttttgcg gcggaccgac agatgctctt tcgaagtttg 2521441 taaaatatcc ggtcccggca tcattataca gaaaatggtg tatagacagg ctgccgtggt 2521501 tcattacaac ccttgaaacg tccttttcct ttgcggactc ataccagtcc tccagccgtt 2521561 ccagcgcaaa gttcaccgcg gaaatggttt cagaaaaata ggttatggcc tggagttcaa 2521621 agggagaaag gtaccattcc ttctccgctc tatccacaaa ctgctcatag aaaattttat 2521681 cttgttccca cttttttttc gtttgcccgt aataacgttc aatctcatca cgtctaacct 2521741 ttagttcctg cgcggttctc tcgtgaagac gggctgtttc tctaaataaa taagcatgtt 2521801 tttgatcccg ttcttcctct tggtcaaatt ggagccaagg cattaaatag tagatatctc 2521861 cgtattgtat gcctgctgag aaaaactcac cgctatttgt tctgtaaacg ggaacgaatg 2521921 aacgaaagcc tttttcctca atcgccacca tatgatctgt aaaatgcttg ccgcgacctt 2521981 ctttcaattt tttcagggca aatatgccgt agtctgtata cactttccaa acaagaggac 2522041 tgacaggctc aataaattga gcagtcagtc cgtattcctg aagaaccgat tgggtatctt 2522101 ccatttcatt caccacattt tccgatcact tacggtttac gcatggctat ttttatattg 2522161 aggaatatag agaatctgtc ctgcttttaa ttcatcatcc aaggctaaag aattcatcct 2522221 gatcagctgc tgggatgtaa tttcataccg ttcgcataaa cgctcgatcg tatcttcctg 2522281 ctgcacaata caaattttca ttctcgaaaa ctcatccgct tcttttgtaa agagttttgt 2522341 taaataaaga gaattatcac tttcctttgt ttgaggttcc ttcgtttcag cagcaggagc 2522401 aaccctagga acagcatccg tttccttcct ttcagtctca gaagattcag gcagctggaa 2522461 ggattgaaaa ggtgtttctt ccttaggctc ttcagctgat ggtgtttttc tcacttcaat 2522521 ttcgaagctc tcttcctctt gttcttcctc ctccagcagc ttaggcgctg aataaaaaga 2522581 atcctcctct tcttgttcag gcaggaaggt acggtatgcc ggttcaggca attcttcttg 2522641 agatgcctcc tccgagcttg ttttttgatt gaaatggaaa tgtaaatcgg cattgtcatt 2522701 ctccatatat acagctgaag ctgtttctct gctatcttct atggagagag cggcctctga 2522761 tacactctcc aaagcttcat ccggttccgc ctcttcttgg caaagcgcag gatcagcctg 2522821 atccgattga gctgcttctt cattttgagc ctcttggcgc agcgcatatt catgattagg 2522881 agacactgtt gtttcctctt tttcctttgc aatcacagtc tctgaatgaa gctcagcttc 2522941 caaagcaggc gattcttctg ctccaacgtg ttcacgaagc tcagtctccg ctggagagtc 2523001 tgcttcttca cgaacatccg ctattgcagc tgccggctct gccgtttctt tttttgcttt 2523061 aacgatctct tgaatctcta tttctgaagg atcaggttct ggctcagatt cttctgtttc 2523121 cgattcagca cgaacctccg tttccggcac agcaagctct tctgactctt cttcctcttt 2523181 cacatcttct ctggcctctg gttctgaagc aaccgattca ggcggctcag attctgcttt 2523241 ttctgtctcc agttcttcac ggagccccgc tttcgagata aaaagttctg gcggttcggc 2523301 tggcggttca tgctgaagaa ctgcttcctc tgccgatgat gcacccggtt cttctactac 2523361 actatgtgcc ggcggctctg aaagctcttc ctccctgaat gccgcaggag cttcatataa 2523421 aggtatctcc ggctctttgt cttgcgtatc gtccaaaagc ccttcgatcg ctaaatcagc 2523481 ttgaattgtt aaaatgcgcg aatccgtcaa ttgatagtca aatgcgtcaa taaagacgaa 2523541 gacatcctgt aaatggctca ctttattttt cggaatggta atatccacag gaaaacagtg 2523601 agtcagttcc gcacttccat cctctctctt tctgacttgt tcaacaaacc gcttatctgt 2523661 ataaatctct tcggtatgtt tgttttgatc tatgttgtac tcacctgtaa gttcaagcga 2523721 tcctatgatt gatacataat catttacttc ctgaacccta atatcaggat ctaatgaaat 2523781 agaaagcagt tcagaaactt cctgtccttt ttggaaacag atcgattctt ctacagaaaa 2523841 ttgcaatcga tgattttgcg gcaagttcat atcctccttt catctaatcc ttaaaattag 2523901 atgtcactaa aggtgtatgt atgaactgga gaaaatatga gtgggagagc acgaaaaaac 2523961 cggcacaagg agtccttgat accggttttc actcttatct gcggctgatc tcagcaaata 2524021 ctttctcagc tgcctggatt gtgttttcaa tatcttcatc agtatgggcc gttgagagga 2524081 aaagaccttc gaattgtgat ggcggaagga ataccccttc atttgccatc cctttataat 2524141 agcttgcgaa cagcttcaaa tcagatgatt tcgctgtttc ataattgatg actggttcgt 2524201 ttgtaaagaa gaaaccgatc atcgaacctg cacggttaaa ggtatgcgga atgccatgag 2524261 ccccggcggt ttttgaaatt ccttcttcca gtctgtcgcc ttttttgatg aaattcttgt 2524321 aggattcagg tgtcagctgt ttcaatgtct ctaagccagc cgtcatcgca agcgggttgc 2524381 ctgacaatgt accagcttga tagatcggac cgcttggagc gatctgctcc atgatttctg 2524441 cctttccgcc ataagcgccg acaggaagtc cgcccccgat tacttttcct aaacaagtca 2524501 gatcaggcgt tacgccgaag tagccttgag cgcagttata atcgacccgg aagccagtca 2524561 tcacttcatc aaaaatcagc agggagccgt actgctcagt gatatcacgc agaccctgaa 2524621 ggaaaccttc ttgcggcgga acaacaccca tatttccggc aactggctct acaatgactc 2524681 ccgcaatgtc ttcaccgaat tgctggaaag caagctttac actttctaaa tcattgtacg 2524741 gaacggtgat ggtgtttttc gcaatgcctt caggcacccc cgggctgtca ggcagaccga 2524801 gagtggcaac acctgaacca gctttaatca agagagaatc gccgtgtccg tggtagcagc 2524861 cctcaaattt taaaatcttg ttgcggcccg tatagcccct tgccaaacgg agggcactca 2524921 ttgtagcctc tgttccggag cttaccattc gtacaatttc tacagatggc acacgatcaa 2524981 tgacgagctt agccagttca ttttctactt cagtcggagc accaaagctt gtcccgtatt 2525041 cagccacttt tttgaggctt tctacgacgc ggtcatttgt atgccctaaa attaaaggcc 2525101 cccatgacaa gacgtagtca atatattcat tcccgtcaat atcaaagatt ttcgagcctt 2525161 ttccgcgctc cataaaaatc gggtccatgt ctaccgattt aaatgcgcga acgggactgt 2525221 tcacaccgcc cggcatgagt ttttgcgctt ctttaaaagc cgtttttgat ttttcatagc 2525281 ttctcatctg cctcaactcc tgtcaactga ataaaattac tccgcaagcc atttcgctgc 2525341 gtctttcgca tgatacgtaa taatcaggtc ggcacccgcg cgcttcatgc ttgtcaaaat 2525401 ttccaacaca atttcttttt ctttgatcca gccgttctgc gctgcagcct tcaccattga 2525461 atactctccg cttacattat aagcgacgag cggcaaagta aactcatttt ttacgtcacg 2525521 catgatatcc atataagaaa gcgaaggttt gacaatcaaa aagtccgcgc cttcctcaac 2525581 atctgattgt gcttcgcgga gtgcctccat acggttggca gggtccatct gatatgtttt 2525641 gcggtctccg aattgcggtg tgctgtttgc tgcatcacgg aacggaccgt aaaactcact 2525701 tgaatattta acagcgtaag acatgatggg aatattgacg aatccttctt tatcaagtgc 2525761 ttctctgatc actgtaacaa atccgtccat catgtttgat ggcgcaatga tatccgcacc 2525821 tgctttcgct tggctgacag ctgtctgcgc caaaagctcc agcgattcat cattgagaat 2525881 gactccgtct ttgacaagtc cgcaatggcc gtggtctgta tattcgcaca ggcacgtgtc 2525941 agcgacaaca accatttcag ggaagtgttc tttaatttct gtgatggctt tttggacaat 2526001 tccgtgatca tggtacgctt gtgttccgca atcatctttt tcttccggga tgccgaacac 2526061 gataacagat tgaatgccca gtttgaccag ctccgctact tcatccttca ataaatctaa 2526121 tgatacatgg tgaacatcag gcattgacgg aacagctttt ttgccttcca gcccttcaac 2526181 gacaaaaatc ggatatataa aatctgatgg atgcaaacgt gtttccttta ccatttctct 2526241 cattgctttt gatgtccgca ggcggcggtg tctattaaat gattgactca tattctctct 2526301 tcctctcttg acatgctgca cattaactca agcatgccat ctattgtaaa tgtatcaggc 2526361 gtatgcgatg tgatgccgta cgtcagaagg gcatcatttg ttaaaggccc aatgctgata 2526421 caggccgtcc cattcgcctt ccactttttt aattcttctc ccaagacatg cataaacgta 2526481 tgtacggttg atgaactcgt aaatgttaca tagtcaaagg aatattgacc cgcagcgtct 2526541 ttcaatgcct caatgccttc ttcatccgga atcgtttcgt agagaaccca ttcctttact 2526601 tcaaaaccga gcgggacaag ctcttgtttt atcacatcac gtgacaaatt ccctttcatc 2526661 acggtaatgg tctcccccgg ttcagcatgc tgcttaagag cgtcagccaa ttgttcagca 2526721 atatactcct gtggcatcac atcaaccgat acgttatgca tttttaaacg gcgcgcggtt 2526781 ttttcaccga cggctgcaat ttttttatgc gcagggagaa taagctgatt ttccttcaga 2526841 taagaaaaaa agaagtctgc cccgttcaca cttgtaaaaa caagccagcc tggcgcggca 2526901 agatcctctc ttacctgttc cgcaacatca ttcggcaaag cgcggcgaaa cgtaatcaaa 2526961 gaggttaaaa ccgctttacc gccaagcgcc tccacttttt gctgaaatga tgctgcctgt 2527021 gccttattcc gggtgacaag cactgttttt cctttcaacg gaaaatcatt ttccatcctc 2527081 gtcaagctcc cgttttacac gatcaattaa atcttttgct cctttgtcag ccataagagc 2527141 ggcacagcgc tttcctactt cctccggatc gtttccggtg acggtttctt taaaaatgat 2527201 tttgccgtca ggtgaagcga caagacctgt catttcaatt tcatcctgtc catttaacac 2527261 ggagtagccc gcgatcggaa cctggcagcc gccctccatc gcgtttaaaa aagcacgttc 2527321 cgctaagaca gtccgttttg tatattcatc tgtaaactga gaaaacaacg ccaacagctc 2527381 ttcatccgat tctcggcact caatcgccag ggctccctgc cccacagcag gcaaacagcg 2527441 ctcaggctca aggaattcgg ttacgacatc ttgcttccaa cccattctgg aaaggccggc 2527501 agccgctaaa ataattgcgt cataatcctc tgtttccagc ttttgaagtc ttgtatctat 2527561 attacctcta atccatttaa ttgtaaggtc agggcgctca atcaaaagct gcgcgcttct 2527621 tcttaaactg cttgtgccaa tgacagcacc tttcttcatt tctgaaagct ttacgcgatt 2527681 ctttgaaata agggcatcac gcgggtcctc ccgttcagga atacagccga tcacaaggcc 2527741 ttcaggcaaa acagcaggca tgtccttcat gctgtgcact gccatatcaa tctcttcgtt 2527801 taaaagcgcc tgttcaattt ctttgacaaa aagccctttt ccacccactt ttgagagtgt 2527861 aacatcgaca atccggtcgc cctttgtcac gatctcttta atttcaaaag caaacgaagg 2527921 attgatttcc ttcagttttt gaataaccca ttttgtttga gtcatagcga gtttgctccg 2527981 tctggaacct actttaatcg ttctcatcat ttctttcctc ccgaatctgc ttgggacatc 2528041 gtttaactga accaatggaa ttgcgacagg cttccaagca ggaaataatt gatcatcagc 2528101 accagaaaac aagccgtatt ccacagtgca gcgacctttc cttgcagctc cttaatcagc 2528161 ctgatataaa gataatagct gtacagcagc aggacgacaa acgaaccaag cactttggcg 2528221 tcaaaccaat acagcgtttc tagtgagaca tacgcccaaa tgacgccgag aatcaaactc 2528281 agcagcagca tcggaacccc aatgacattt aaaacatacg ccatataatc aagcttagat 2528341 aaatcttcta ttctcaacag ccattttccc cactttttct ttttcagcag atgatattga 2528401 aacatatata gcacagaaaa aacgaaagaa agggaaaaag cgccgtatga aagaatcgcc 2528461 attgtaatat gaatcaccaa aagctcggat acaagctgcc cggaaaaagc agctgactgc 2528521 tgctctgtcg gtgaaaatgt gtgaatggcg atcatagaaa atcctataac atttgtaaaa 2528581 aacacgataa agtcaacacg taaaagcttt gtcagtacaa gtgacagcgt gacaagcacc 2528641 caggcataaa aataaagtgc ctctgtcaca tttaataccg gaaaccgccc cgtcacccac 2528701 ataaaatagg ccaaatacac ggtttgcaga gtccagacaa tagaaagcaa ccagaaggcc 2528761 atttttccag ccttccggtt gtgttgaaga aaatctataa aataaaagag tacacttaac 2528821 gcgtaaatga cgattgtccc ctcattaagt cttgccattg cagtatcaat cattcagctt 2528881 tcactcactt acaagtgggc taaagcccgc ttttgattca gccttcttaa aagagtggac 2528941 cttctggctg ctttcaacgg ttttcatcat ttgacggccc gcagcttctt caatatcaaa 2529001 aatctgcata aacaacgcga gcttttcttc agaatcagca tctgccgcaa gctctttcac 2529061 ctttaaaatc ggatcacgaa gcatttggtt aataatactt ttggtgtgtt tgttcaacag 2529121 ttttttctct cttgtgctta agtgaggcag cttacgctca atgctgtcca tcgtttctga 2529181 ctggatggca agcgcctttt cgcgcaatgc agaaataaca ggcacaacac caagtgtatt 2529241 catccattgt ttaaattcca caatggtttc ttcaattaac agttcaactt tttcagctgt 2529301 ttctctccgc tctttcatgt tcgcttctac aatgccttcc agatcgtcga tatcataaag 2529361 aaaaacacct tcaagatcat tcagcgccgg atcaagatct ctaggcacgg caatgtcgac 2529421 cataaacagc ggacgtccct tgcgaagctt attcgcgttt tccatcatct ctttggacac 2529481 gacaaattca cttgcaccgg ttgaactgat taaaatatca gcctccgcaa gcgcgctttc 2529541 aagctgattc aagcttctcg cttcacctga aaaacggtct gcaagctcct tcgctttcaa 2529601 gtatgttcgg ttaatgacag tgaccttgcc gattccctgt ccgtgcaggt tttccgcagc 2529661 aagctcgccc atttttcccg caccgagaat caatatgtgc ttgcttgaaa gatttccgaa 2529721 gatttttttg gcaagttcaa ctgcagcata gcttactgac accgcatttg agccaatgtc 2529781 tgtttcggcg tgagtccgtt tgcccactgt aactgcctgc ttaaacagct cattaaaaat 2529841 agtcccgatc gttttttctt gctgagctgt tttaaagctg tcgcgtacct gtccgagaat 2529901 ctgcgtttcg ccaatcacca tagaatcaag tccgcaggct acacggaata aatgctcaac 2529961 agcggcatcg ctctcataaa acgttaagaa cggtgacagc tcttctttgc ttaattgaaa 2530021 ccaatcagct aaaaactttt ttatataata acggccggta tgaagctggt cgactaccgc 2530081 ataaatttca gtgcggttgc aggttgagac aatgatgttt tcaagaatgc ttttctcttc 2530141 tttcagctgc accattgctt ctgccagctc attcggctga aaacttactt tttcacgtat 2530201 ctcaataggg gcggatttat aatctactcc cacaacaagt atatgcatcg ctctaattac 2530261 acccccaaca cccaatctta atttataatc attctaacat agaactcatt atttataata 2530321 attataacat agtttctttc acaaaatgtg aacagatttt aaaattctta tgctatatta 2530381 gaaaaagctt cagggaaaag aagcattcct attgacaata ccaaaaacag cagaaattta 2530441 ctacacatca gctctaaaaa acaagaaggt gatatgcatg aaacaaaaat caattttatt 2530501 cccttgtctg ctgcttgccg cttctgtata tgcatggcta gaaagcggcc aagccgaact 2530561 gttttcaggg caggatcaat ggcctgttct cctcatgctg ttaggcgcag cctttgtata 2530621 tcaaggaaaa aaagaagccg tcacacccca tttttttatc ggtttgcttc tcttcgggat 2530681 cggtttacac ttttttgcca agccgaaatg ggtatggtgg ccggatgatt ttgaaatgct 2530741 cctctttatg atcggcttct cacttctcgt ttcaaccgtt caaaaaaaag aatatgtata 2530801 tgaagctgtg tcgatgattt gtttttccct gtttttgtac tttttcaaac aaattatggc 2530861 atggcttgag tctgcgcata ttccaacagc gcttctgaag gagtattggc cgtttgtctt 2530921 tattggaatc agtttattgt tattattgat aaaacgaaaa aaatctatac gataaataaa 2530981 accggtagag gatcctctac cggtttatca tttttttgat cgctccccaa gcttcgtctt 2531041 ttcccttttt cgtttctgaa gaaaagagga tcagctcgtc ttccggatca atatttaatg 2531101 tttgtcggac aaccttcgcg tgtttgtccc atttaccttt cgggatctta tccgcctttg 2531161 tagcgataac aataacagga atgccgtaat actttaaaaa ttcatacatc tgtacatcat 2531221 cattagatgg cgcatgccgc aaatcaacga tctgcaccac agcttttaat tcctcgcgtg 2531281 tcgtgatata ggtttcaatc attctgcccc atgcttcacg ctcagacttt gacactttgg 2531341 caaaaccgta gcccggcaca tccacaaaat gcagctcatc attgataatg tagaaattaa 2531401 gcgtttgtgt ttttcccggc tttgatgacg ttctcgcaag atttttgcga ttgattaatg 2531461 aattgataaa agacgatttt cctacgttcg atcttccggc caatgcgatt tccggaagcc 2531521 ccccttcagg gtactgttcc ggttttactg cactgatcac gatttctgac tttgtgactt 2531581 tcatttcttc tctcctacta aggcatgttc caaaacctcg tctaagtggg acgccaatat 2531641 aaatgtcagc ccctccctga cgctttccgg aatatcctct atatcttttt cattatcttt 2531701 aggcgcaata atggtcgtta atcccgctct atgtgcgcca agcgcttttt cctttaagcc 2531761 gccgatcggc agcacgcgcc cgcgaagcgt gatttcccca gtcatgccga cttcacgcga 2531821 aaccgcccgt cccgttaaag cagaaacaag cgctgttgcc atcgtaatac cggctgacgg 2531881 accatctttt ggcaccgcac cctctggtac atgtatatga atatcatact tctcatgaaa 2531941 gtcaggttca atgccaagtt cttctgtttt ggatcgcaca tagctgaatg cagcctgagc 2532001 agactctctc ataacatctc cgagctttcc tgtcaggatt aatttccctt ttcccggtga 2532061 aagcgatact tcaatcgaaa gcgtatctcc gccaacggtt gtatacgcaa gccctgtcac 2532121 tacaccaact tgatcctctg tttcagcttg tccatatctg aaaatgcgtt ttccgataaa 2532181 atcttgaagg ttcttctcag taaccgtaat tcgttttcgc tcttcagcaa caatggcttt 2532241 tgcagcttta cggcaaattg cggcaagctg gcgttcaagg cttcttacac ccgcttctct 2532301 cgtatagtaa cgaataatat caagaatcgc ctgatcacgc agctgaagat tgcttttctt 2532361 cagcccgtgt tctttgattt gctttggaag caagtgatcc tttacaattt caagtttttc 2532421 tatttctgtg tagcctgcga tattaataat ttccattctg tctctgagcg ggcccgggat 2532481 tgtggccaaa ttgttcgccg ttgcgataaa cagcactttg gataaatcaa aggtttcttc 2532541 aatatagtga tcactgaagc tgctgttttg ctctggatca agcacttcaa gcatagcgga 2532601 tgatgggtct cctctaaaat cagatgacat tttgtcaatt tcgtctaata agaagaccgg 2532661 attcagcttg cccgcttttt tcatcccttg aataatacgt ccaggcattg ctccgacata 2532721 ggtccgtctg tgtccgcgta tctctgattc atcccgaact cctccgagtg agattctgac 2532781 gaatttgcgt cccaagcttt ttgcaattga tttggctaaa gacgtttttc cgacacctgg 2532841 aggtcctgcc aaacagagaa tcgggccttt cagggatttt gtcagcttct ggacagccaa 2532901 atattctaaa atacgttctt ttactttttc aagcccgtgg tgctcttcgt ccaagagacg 2532961 tcctgcttct ttcaaatcaa gcttatcatc tgtttcatcc gtccacggaa gagcaaccag 2533021 ccagtcgata tagttgcgga tcacagagct ttccgcagaa cttgacggaa ttttttcata 2533081 tctgttcaat tctttaagcg ctgtttcttt cacatgatca ggcatgcctg cttcttcgat 2533141 tttttccgtc agcgtctgaa cttcgccagt tttgccttct ttatcgccaa gctctttttg 2533201 gatcgccttc atttgttcac gcaagtagta ttccttctgc gtacgctcca tcgaacgttt 2533261 gacgcgctgg ccgatttttt tctcaatctc cagcacttct ttttcattat taataaaatc 2533321 aatgaccttg ttcagcctgt ctttgacatc agccgtttct aaaatatcct gcttatcctt 2533381 tagtttaagg ggcagatgag aagcaacgat gtctgccatt ctccccggct cttcgatatc 2533441 agtaaccgca gcgtacgttt cggccgagat ttttttagaa atttttatgt actgatcaaa 2533501 gtggtctagc aaagtccgca tcaatgcttc gtcttctgta tcttttgaat catcttcatg 2533561 aataagttga atgtcaaccg acgtgtaatc ctcgtgttca ttgtatttga cgatatgggc 2533621 gcgcttgagg ccctccacca acacacgaat cgtaccgttc ggaagcttca gcatttgctt 2533681 aatttttgta taggtgccga cagtgaaaat ctcgtcttca ccaggttcgt ctatcgaaat 2533741 atcctgctga gtggctaaaa atatcatatg atcatgcatc attgcctgtt caagagcctg 2533801 aaccgacttg tcacgtccta catctaaatg caaaaccatc gtcgggtaca ctaataaacc 2533861 tcttaaaggg aggagcggga tgctgcgttt taattcttct gccatgtgac tgacacctcc 2533921 gtgactttag tatgaaccat tataatacaa ctttttcatc cttgtacaat aaacggcatg 2533981 gttccatttt ctataaaaca gtctcctcgt agtataccct ttctttctga tatgaaaaag 2534041 gaaaagatgt ccttcatgaa aaaaacccta ttatcaaaat agggtttaaa cggattcttt 2534101 attgatttcg atatgaaacg gtttttgttc cgttggcgga ttcaccaaaa tttcatcaag 2534161 cacttcttgg aacgtcttca ctgcaataat ctcgatcccg tcaatctgct ttaagatggc 2534221 ctgctgattt tcatatggga taatcacctt tttcgcaccg gactgcttgg ccgcttttat 2534281 tttcggaatg acgcctccga tgggtttcac aagaccgttc aggctgattt cgcccgtcat 2534341 cgcaacggta ttgtcaatag gaattttgtg tatcgccgag aaaatccccg ccgccatcgc 2534401 aatgcctgct gacggcccat caatcggaat ccctcctggg aaattgatgt gaatatcata 2534461 atcagaaggc ttcattccca ttgtccggag cacggttaat acattttcaa ccgaaccctt 2534521 cgccatgctt tttcgcctga tcgattttga ttggctgccg atgctttctt cttcagctat 2534581 tcctgtgatg ttaattgatc ctttatcttg agccgcggtt acacttactt cgatttccag 2534641 aagcgatccg ctgttaggcc catagactgc aagcccattt acaatgccaa cctgtggttc 2534701 aacaccgatt ttttgctcgt gctttggagt aagctgactg gagtgaatga cccattcaat 2534761 atcctcaatc gtaatgtcct ttcgattctc cgttacagcc atccccgctg cgatttgaat 2534821 catattgacg gcttcccgcc cgttccgcgt gtagctggtc aaaagatcca gtccttcttc 2534881 ggagatattt ttttcaattt tatccgctgc tgttttggca accgttttca gctcgtcctt 2534941 ttcaagctcg cggaaaaaaa cctccaaaca gcgggaccgg atagctggcg gaatttcgtt 2535001 tggcattctc gtggtcgcgc caatcaagcg aaaatcagcc ggcagcccat tttgaaaaat 2535061 atcatgaata tgattcggaa tttgtgtatt ttcctcactg taatacgcac tgtctaaaaa 2535121 gacttttctg tcctcaagca ccttcagcat tttattcatt tgaataggat gcagctcccc 2535181 tatttcatca ataaacagca caccgccatg ggcatgggtg acagctccct gcttcggctg 2535241 cggaatccca gcctgtccca tcgctccggc cccttggtat atcgggtcat ggacagagcc 2535301 gatgagcgga tcggcaattc ctctttcatc aaaacgggct gttgtcgcat cgagttccac 2535361 aaagacagcc tgctctttaa acggtgattg tttatgtttt tttgcttctt ccaacacaag 2535421 ccgcgcagca gccgttttcc caactcccgg tggcccatag acaatcacat gctgaggatt 2535481 tggcccgcat aaagccgcct ttaatgcttt aatgccgtct tcctgtccga cgatatcttt 2535541 aaagcttttg gggcggacct tctcagataa tggctcggac aagctgatag cgcgcatttt 2535601 ccgaagctgc tccatttcct tctttgattc tttatctatc gtgacctttt gtgtcctttg 2535661 atttttaagc aaattccaaa aatacaaacc gatgatgatc ccaaaaaaca gctgaataaa 2535721 taacgcgatc cctgtccaac tcatggtggt ccctcctgaa aaacaattta tgtatccaat 2535781 tcattcctct gattgctagt atctcccata gaagacggga ataaacgttt ttccggaaga 2535841 gttgcatgca aaaaaacctc ctgagtgtta ccactcagga ggtttgtgct tatctttatg 2535901 cagatgtttt atcttggctt acctcagtgc cgtcttttaa taagaggcga ggaggctctc 2535961 cgtgtgtcac agttgccccg gtgattacac atttttcaat gtcatcacga gaaggcagct 2536021 caaacatcac atcaagcatg atgccttcaa tgatagaacg gagtccgcgt gctccagtct 2536081 tgcgttcaat tgctttttta gcaatttcag aaagcgcttc ttcttcaaac tcaagctcaa 2536141 cgttgtcaag ctcaagcatt ttcttgaatt gcttaacaag agcgtttttc ggttttgtta 2536201 agatcgcaac caatgcttct tcgtcaagct tttcaaggct tgcaataacc ggaagacgtc 2536261 cgataaattc aggaattaac ccgaaacgga gcaaatcttc tggaagcact tttgaaagaa 2536321 gatcttcttt ctcaagatca gcagctttat tgtcggcacc gaatccaatc actttttggc 2536381 ctaaacggcg tttgatgatt tgttcgatac catcgaaagc tccgccgcaa atgaacaaaa 2536441 tatttgttgt gtcaatttga atgaattctt gatgaggatg cttacgtcca ccttgaggcg 2536501 gtacgcttgc cactgtaccc tcaagaattt taagcaatgc ctgctgtaca ccctcacctg 2536561 acacatcacg tgtgatagac gggttttcag attttctagc cactttatcg atttcatcaa 2536621 tatagataat gcctttttcg gctttttcca catcataatc agcagcttgg atgagcttca 2536681 agagaatatt ctctacatct tcacccacgt atccagcttc agtcaaagat gtagcgtccg 2536741 caatcgcaaa cggcacattt aaaatgcgag ccaatgtttg cgccagaagg gttttaccgc 2536801 ttcccgtagg gccgattaat gaaatattac tttttgaaag ctcaacatca tcaactttgc 2536861 tgttggagtt aatgcgctta tagtggttat acacagcaac agcaagtgat ttcttcgctt 2536921 gatcttggcc gatgacatat tcattcaaaa tttcgcgaat ttcctgaggc tttggtacgt 2536981 ctttaaattc tacttcttct tctgttccga gttcttcctc tacaatttca gtgcagagtt 2537041 cgatacattc gtcacatata tatacaccag gtccagctac aagcttacga acctgatctt 2537101 gtgtttttcc acagaacgag cattttaatt gtcctttttc ctcgttaaat ttaaacattc 2537161 tttcacccct taatcttgtc tcactttttc ttttaccggc agagcaaaag aaaatgattc 2537221 ttgaaacgaa cgagtatgta ttgcatttta ccatactttc caaaaagacg gtaacaatgt 2537281 gtttctgact tgcacattct atatgtatga caaaaaacag ccctgcatta actatattgc 2537341 cccaagaaaa agagataact cataattgta caaaacaagg cacgaatgat tcgcgccctg 2537401 ttttattagt actattatta tgcaccatat taacggtttt ctacaagaaa atcaattgct 2537461 ttgcgaactt ttaaatcttc tttcatcgcg tcagtagaac cgatggcttg tttaatattt 2537521 tcaacaggca tgttgtatgc ttcagccatt tttgtaagct cagcatcaac ttcctcatct 2537581 gatacttcaa ggttttccgc tttcgcaatc gcctcaagag tcaggttaga ttttacgcgt 2537641 ttttcagcat cttctttcat ttgctcttta agcgcagctt catcttggcc tgagaattga 2537701 gtgtaaagct caaggttcat gccttgcatt tgcagacgct gttcgaattc tttcagcatg 2537761 cggtcaagct cagtgtcgac cattgcttga ggcacatcga tttcagcatt ttcagaagct 2537821 ttcagaacaa gctcttcacg caatttagcg tcagcttcgt tttcttttgc ttcttctaaa 2537881 cgtttctttg ttttttcagt taattcagca agtgtttcca cttcttcatc gatatctttt 2537941 gcgaattcat cgtcaagctc aggaagctct ttcgctttga tttcgtgaat tttcacttta 2538001 aacacagctg gtttgcctgc aagatcttca gcgtggtact cctcagggaa tgtcacttca 2538061 acatccttct cagcacctgc ttcaaggcca actaattgat cttcgaagcc agggatgaat 2538121 gaaccagaac ctacttctag agagtagttt tcagcttttc cgccttcgaa agcttcgccg 2538181 tcaacgaatc cttcgaaatc aagaacaact gtgtttcctt cttcaacggc gccttcttct 2538241 tttacaacaa gctcagcttg acgctcttga agggctttta gttcgttttg aacatcttcg 2538301 tcagttacag ttgtgtcgtc tttttcaatg cccaggcctt tgtattcgcc aagcttcact 2538361 tcaggtttta ctgttacttt cgcagtgaag attaagcttt cgcctttttc gattttttca 2538421 acatcgattt caggacggtc tacaggctcg attccagctt cttcaaccgc tttagggtat 2538481 tctacaggaa gaagaatatc caaagcatct tggtaaagag cttctacgcc aaagcgctgt 2538541 tcgaataatc cgcgaggaat tttaccttta cggaatccag gaattgaaac ttgttttact 2538601 acttttttaa atgcatcatc aagtgctgtt ttaaacgttt cagcatcaac ttcaaccgtt 2538661 aaaacgcctt cgttgccttc ttgtttttcc cattttacag acatgtgttt ccctccaaaa 2538721 atctattcag gttgtgtcgg tcttccattc taaagcaatc attcggcttc gtccaacaaa 2538781 aacaaagctg ccaaagatca gaatcattat gtatagatgt taataatgaa ctgcaaagcc 2538841 tgtccaaccg tatttcttat aacccgttat acacaaatac aaccactata ttataacata 2538901 acacatagcg ctttcaacta tatggcgcga tttacaaata agaaatttct tcaatatctt 2538961 ttaacattgt gcaagcttca tcgagttctc tgtctgtaaa ttcatacatc atatgaagtt 2539021 cttcgctttc aatttcaatc ccgtgcatct cgtaaccgac tttatgaagg gcagccgccc 2539081 aaaggtcagc cgacagcaat ttcggctgga acggatataa aacgtacaaa tgtcttctcc 2539141 acaattcttc tactgctgca tataaggttg gattttcatt tccaagtgtc tcatctagca 2539201 ccctgagaac acggtgaaga atcggcgcgg catcaggcgg aacaatctct gacggttcaa 2539261 ttgtcaacga ctcgccaaat ttactaatgt gtacaggttt actgtactca tgctcagcca 2539321 acagcatgac aatcatcgtt ttgataatcg gatgggctga ggggtcttgg aggattgttt 2539381 tgagcaatcc tgtatacttt gctacgttac ggtcttttaa ggaatgaatg agattcattt 2539441 gctcctcagg gcttgccagc actttctcgg tgtcaattgt atcctcatat tcttcggccc 2539501 aagcctcgtc ctcacgatcc ggatcggtca ttttccggct gaaatccagc agcttataaa 2539561 attgctcggc actttctgcc ggcagctgat tttcttccaa aacggcttca atggtgcttt 2539621 tgacttcttc gtactttttg agctgaatta agatggtcat gtacacctgc aaaaccgtaa 2539681 aataatggcc ataaccttct ttgagcatct tctcgcacac gctttctgcc tcttccagct 2539741 cgcccagctc taaaaagcag atggccatcc ctaagtgaag atcggattca gtatcatcat 2539801 atttcatcgc ttctgaaaac agttcaagcg cttcttgata ctttttttcc ttgagtgatg 2539861 acatcccttt ttccacaagg cggtctttca gatgaggaaa aggaataatt tttgcgtttt 2539921 tcttgtcatg cgtcatacct atattccttt caggcattta ttttgttcaa gtgtatcaac 2539981 acctgtgaac aaaaacaaga aatgaaaggt ttcaccaggc aaaaaaagcc gccggacaaa 2540041 taccggccgc tttttcaggc ttgaagccaa gagcttcttt gtgattcaaa ttgcttgatt 2540101 tcatcttcca gcagcagcgt taatgaaatt tcatcatatc cgttgatcag catctctttc 2540161 caatgcggat caacttcaaa tgaaatttga ttgccttcac tgtcatgaat cagctgattt 2540221 tcaaggtcaa cagtcatttg caatgactgg ttttcatact ggccgacaag ctgtttccaa 2540281 ttgtcatatg gcatgcggat cggaagcatg ccgtttttaa agcagttctg atggaaaata 2540341 tcagcgaatg acggcgcaat gataatttta aacccataat catcaagtgc ccacggagcg 2540401 tgttcacgcg atgacccgca gccgaagttt tctcctgcta ttaaaatgga agctccttga 2540461 taaacaggct ggtttaattc aaattcaggg ttcggttcac cattcgcatc atatctccag 2540521 tcaaagaatg caaaacgtcc gtagcctgtt ctttcaatcc tcttcaaaaa ttgcttagga 2540581 ataatctggt ctgtatccac attgatccga tttaatacgg ctgctttccc cgtatgtgat 2540641 ttcaaaggtt ccatctcgcg cactccttac acaactgttt tttcctgata aaactttctg 2540701 acatcaacga agtgtccgtg aatggcagcc atcgcagcca ttgccgggct gacgagatgt 2540761 gttcttgcac cttttccttg tctgccctcg aagttgcggt tagaggttga tgcacagcgc 2540821 tctccctcag gaacaacatc attattcata ctcaaacaca tgctgcagcc tgactctctc 2540881 cattcaaatc cagcttccaa gaaaatctgg tcaagccctt ctttttcagc ctgaagcttc 2540941 acgctttggg atccgggcac gacgatggcc cttacgctgt cagctacctt cttccctttg 2541001 atcatgtcag cagcctgtcg aaggtcagtc atgcgggaat ttgtgcagga accgataaat 2541061 acgtgctcca ctttaatgtc ttcaattttt tggtgaggag tcaatcccat atattcataa 2541121 gcacgaatcg cttctttttt atcgtcttct gcagaaaagc tttccggcgc aggaacttca 2541181 gaatcgacag gaagaaccat tcccgggtta atgccccatg tcaccatagg ggaaattttg 2541241 ttgccgtcaa ggacgataga tttatcgtaa acagcgcccg ggtctgtgcg cagcgccttc 2541301 cattcctcta cggccttgtc aaattcttcg ccttttggcg tgtacttgcg atttttgcaa 2541361 tattcaaacg tcacctcgtc aggtgcaatc aaacctgctc ttgctcctgc ttcaattgac 2541421 atgttacaaa cagtcattcg ttcatccatc gtcatatttc tgaatacttc cccagtgtat 2541481 tcaatgacgt agcctgtgcc gaatttcaca ccgtatttgc cgatgacagc aaggatgaca 2541541 tcctttgccg ttaccccttt ttgaagcgtt ccatctacgc gcacttcaag tgtttttgga 2541601 cgctgctgcc aaagtgtctg tgtggaaagg acatgttcaa cttcactcgt cccgattcca 2541661 aatgcaagag cgccgaaagc gccatgtgtt gatgtatgac tgtcaccgca cacaatcgtt 2541721 ttccctggaa gcgttaagcc tagttcaggt ccgacgacat ggacaatccc ttgatccaca 2541781 ctgtgaagat cggcaaggcg cacgccaaat tcctcacagt ttctttcaag cgccgttacc 2541841 tggcgtttcg caacttcatc ctttatctca aaacgattga cagtcgggat gttgtggtcc 2541901 attgtcgcaa atgtgttttg gggtcttctg acctttcttc ccttttgtct caagccttca 2541961 aatgcctgag gagacgtcac ctcatgaatg aggtgcaaat caatatagag aagatccggc 2542021 tttccctcac catgttttac aatatgctga tcccaaatct tttcgatgat tgttcgaggc 2542081 atcatctttt atttcctccc tctacctaga gctaagaccg cttaacgtaa gctgtcacac 2542141 attagaaatt gtattttcac tcatgattgc tgccttaact tcctctgtaa tggcctgagt 2542201 gctgctgaac tcttcactcc gtgccaagtc tcttgttctt tttccagaag ccaagacttt 2542261 gtttaccgca tcttctacag ctttcgcttc ctcttcaagc ccgaaagatg ttctcaaaag 2542321 cattgccgct gacaatatgg ctgcgaacgg atttgccatc cctttaccgg caatatcagg 2542381 cgcggagcca tgaacaggtt caaacagatg aaggccagag cttgataggc tggctgacgg 2542441 gagcattccg agcgagcctg taagcatgga cgcttcatcg cttaaaatat caccgaacat 2542501 attttcagtc accacgacat caaattgatt cggtgcataa attagctgca tggccgcgtt 2542561 atccacaagc atgtgctcaa gcttcacatc aggaaattct tgtgcaacgt cctcagccac 2542621 ttcacgccac agccggcttg attcaagaac attcgcttta tctacagagg tcactttgcc 2542681 ttttctggct gccgccattt tgaagccctc tctgatcact cgttcaattt ccgttcgctt 2542741 ataaaacagt gtatctactg cttcctgctc accttcagtg tttacataac gtttgctcgg 2542801 ctggccgaaa tacaagccgc ctgtgagctc acgaacgata acgaaatcaa cattatctat 2542861 atattctttt ttcaaaggcg aagcgtcaga aaggctttca aataccttca caggccgcaa 2542921 attcgcaaac aaatcaagct gttttctgat gctgagcagc cctttttccg gtctcagttc 2542981 cgaaggattt tgatcccatt tcggtccgcc gacagcacca agcaatatcg cgtctgcatt 2543041 tttacaagca gcaacggttt cctccgggag ggggttatga tgttcatcaa tagccgcccc 2543101 tccaatcagg ccatattcaa attcaaattc atggttaaag cgttcggcaa cacttttcag 2543161 tacgtctgtc gctgattcta atacttcagg gccgatcccg tctccgggca atagagcaat 2543221 acgtttcttc aagttaaccg ttctcctttc ttttatgatc cgacagctgt gtggtttttc 2543281 aatccgctca tattcgactg gaaaaccaat tgacggttta ctgcgttcaa ataggctttc 2543341 gctgatgctt ctaatacgtc ttgcgctatg ccccgccctg ctgattcttt tccgttcacc 2543401 aaaactctta catacacctg ggcaaatgca tcttcgcctt ttctattaga ctgaatgcgg 2543461 tagtctaaga gctccacatc cttatcgatg cagcgctcaa gcgtattgta gattgcttcc 2543521 acgcttccag ctccagttgc agcttcctga ataagctgtg cgttttcttg atttttcaaa 2543581 gatagagtag ccgtagggac ctgacttgtt ccgtaatgta cttgcagaga aagaaattca 2543641 tacccaatct tgcgatctgt tactttttct tctaaaataa gagaaacaag atcctcatca 2543701 gtgatttctt ttttcttctc agtcaactct ttgaacatcg taaagaattt attaatctct 2543761 tcactgtcaa attggaatcc taaagcagtc agccggtctt taaatgcgtg gcgtccggaa 2543821 tgtttaccta ggacaagcgc atctgcggtt acgccgacaa gctccggtga aataatttca 2543881 taagtcgatt tttcctttaa aaagccgtcc tgatggatgc ctgattcatg agcaaatgca 2543941 ttatctccaa caaccgcttt gttgcgcggg acagccatgc ctgtcagttt gcttactaaa 2544001 tcacttgttc tcttaatctc gttcagcgta atacctgttt cgacttggta gaaatctttt 2544061 ctggtatgga gggctacggc aatttcctct aatgccgcgt ttccggctct ttcaccgatc 2544121 ccgttcacag cgcattcgat ttgatcagcg ccattttcaa tcgcagcaag agagtttgcg 2544181 actgccattc ccaaatcatc atgacagtgg gctgaaagct ttgctttgtg aatgttcgga 2544241 acgttttctt tcatatattt aaagatattt ccgtattccg ccggggccag gtagccgaca 2544301 gtgtccggaa gattgataac actggcgcct gcgtcaatca ctttctcgac gatttctgct 2544361 agaaacggca gttcagtgcg gcaggcatct tcagctgacc attgcacaat cggaaaacgt 2544421 tcttttgcgt atttcaccat tccaactgct ctttcaatga cttgttcacg tgtcattttc 2544481 agcttgtgct tcaaatgaat gtccgatgtc gcgataaata catgaattct tggttgagcg 2544541 ccatccttta acgcttccca agcagcatca atatcacctt ttacacaacg ggccagacca 2544601 gttactgaac aatttttaat ggttcttgcg atttcctgaa cagctaaaaa gtcacctcgg 2544661 gacgaagcgg gaaatcccgc ttcaatgatg tctgccccga gtctttcgag ctgcttagct 2544721 atggcaagtt tctcctgtgt attcaagttc actccagggg actgttcacc atcacgaagc 2544781 gtcgtatcga aaaaattaat tttgcgcaac ggagaccacc gcttccttct tcttgccttg 2544841 tttcacaaac ggcatcattt cacgaagctt tcttcccact acttcgattt gatgttcgtt 2544901 ctcgcttgca ttgatagcgt tgaaacgagg acggtttact tggttttcga cgatccactc 2544961 ttttgcgaat gtaccgtttt ggatatcttt taatacttct ttcatagatt cttttacttt 2545021 ggcgtccaca acgcgagggc ctgatacgaa atctccccac tgtgctgtgt cagagattga 2545081 atatctcatt cctgcaagtc cttcttcgta cataaggtct acgattaatt tcagctcatg 2545141 aagacactcg aagtatgcaa gttcaggctg ataacctgct tcagttaagg tttcaaatcc 2545201 ggctttgaca agcgcgctta atccgccgca aagaactgct tgctcaccga acaaatctgt 2545261 ttctgtttct tctttaaatg tcgtttctaa tacgcccgct cttgcgccgc cgattccttt 2545321 agcataagcg agggctttgt ctcttgcttc tccagtcaca tcttgataga ttgcgaacaa 2545381 tgcaggtacg ccagctcctt gctcatatgt tcttcttacc aagtgtcccg ggcctttagg 2545441 ggccactaag aatacatcta catccgccgg aggaacaatt tgatggaaat gcacgttaaa 2545501 tccatgagcg aatactaatg attttcctgc tgtcaattca tctttgattt cagcttcgta 2545561 tactttttgc tgctgctcat ccggaagcag aaccatgatg atttcggctt gggctgccgc 2545621 ttcttttact gaaaatactt tatgtccgtc ttcttgggct tgagtgaaag attttccttg 2545681 tctaacaccg acgatcacgt ctactccgct ttctttaagg ttcagggcat gtgcgtggcc 2545741 ttgcgaaccg tacccgataa ccgctactgt ttttccagcc aatacgttct ctttgatatc 2545801 accgttataa tatactttta ccatttcaat ctctcccttg ttatgtttta tacaatagat 2545861 attgttttat tggatgacgc cttttgctgg gttcccctcg caaaagccgt tgtacctgtt 2545921 ctcgcgattt ctttaatgcc ataaggtttt aataactcaa taagcgcttc aattttgtta 2545981 gattcacctg tcacctgaac aacgatgctg tctctgctga catcaacgac agaggctcta 2546041 aacggttcta tgattccatt aatctctgtt cttgttgaag gtgcggagac aaccttgatt 2546101 aaggccagct ccctctggac aatcgattga tttgtgatgt ctgtgacttt cagcacatca 2546161 atctgtttgt tgagctgttt cgttaactgt tcaacatcat tttcaccttc aacatgaacg 2546221 acgaaggtga ttctggaaac gccggctgtt tctgtgtgtc caactgtaat gctttcaatg 2546281 ttgtaatgcc tttttgtgaa tagaccggtg atccggttta acaccccgga gcggttcacc 2546341 acagtcaatg tgataattct tttcaaggtt tcacccccac catttcatgc agccctttcc 2546401 ccggagccac catcgggaat actttttctt cgctggcaac ccgcacgtca atgacaacag 2546461 gttctcttga tgttaatgcc tcttccagct tttcctttgc ttccgcttct gatgaaattc 2546521 tgatgccttt aatgccgtat gcttcggaca atttgacgaa gtcaggctga gaagcgaatt 2546581 tagattctga ataacgttct tcatagaaaa tttcctgcca ctgtctgacc attccgagac 2546641 aagcgttatt taaaatcact accttgaccg gaagatttaa ttcgcgaata acatcgagtt 2546701 cttgaagcgt catttggaat ccgccgtctc cgacaaccgc gacaacagta gcatcttttt 2546761 cggccagctg tgcgccgatc gccgccggaa gaccgaatcc catcgttcca agtccgcctg 2546821 acgtgaccca tttatctgct ttttggaacg gataaaattg cgctgaccac atttgatgct 2546881 ggcctacatc cgttgcgaca atggcctctc cttttgtaaa ttgatgaata tattcaatca 2546941 atttctgagg tttaaaacct tcttcttcat tatctacata ccagagcgga tactcttctt 2547001 tccattctgc gagctgtttt ttccattcgc ttgaatcgct ttgtttgccg tcttgtttga 2547061 tcagctcctg caggacaatt ttgctgtctc cgactacagg aatctgtgtt ttcatgattt 2547121 ttccgatttc agctggatca atatcgatgt gggctatctt tgcgtttctg gcaaagtgtt 2547181 tcaggtttcc tgtgacacgg tcatcaaaac gggcgccgat actgattaat agatcacatt 2547241 catgaagggc catattggct gtataagtac cgtgcattcc cgccatccct aggaaaagcg 2547301 gatggtcagc cgggaagcct ccgagcccca aaagggtgtg tgccacaggg atttgctgct 2547361 gttcagcata attttttaat tcttctgacg cttttccgtg cagtacgccc gcacccgcca 2547421 ggatcaccgg ttttttcgca ctgctcacgg cttccacaag cttgcggatc tgcaaataat 2547481 tcggctctgt tgtcggctgg tatcccggga gattcatctc atgatcgtag ctgaattctc 2547541 cttcaattgt tgctacatct ttcggaatat caatcaatac aggtccgggt cttccagttg 2547601 ttgcaatatg gaacgcttct ttaatgatgc gcggcagatc ttccggctgg cgaacctggt 2547661 agctgtgttt tgttactggc atcgtaatcc ctaaaatgtc tgcttcctga aatgcatcgc 2547721 tcccgattac agaggttgct acctgccctg taaagacgac taacggcaat gaatcaatca 2547781 tggcatcagc aaggcctgta acaaggtttg tcgctcccgg ccctgacgtg gcaatgacga 2547841 cacccggttt tccggagacc cttgcgtatc cctccgctgc atgaattgct ccttgttcgt 2547901 gacggggaag gatatgtacc aaccctgaat tgtatagctt atcgtaaatc ggaagcacag 2547961 ccccgcccgg ataaccgaag atcatttcta ctttctcttt ttttaatgat tcaatcagca 2548021 ttaatgctcc gctcatcgtc tgtgtacatt cggcagatgc tgaatccacc tgtacattag 2548081 tccccatttt agttcctcct tttggatttt catcctttaa agatcatctt ttcattagct 2548141 agatagctga ttattcaata aaaaaagccc ttccgcccac aatcagccgc gcagtaactg 2548201 cgatagctaa aaggggcgaa aaggcttttc tttccgcggt accacccttg tttacggcct 2548261 gttaatcggc cgtctcatgg atatttctat ccgctttagt aacgagtgaa tcaagttcac 2548321 ccggccaagt cctactgtca tttcagactg gcactctgag gcgagttcac cttgtaaagc 2548381 ttcgccggtt ctcagctaac ccggttctct gtggaaaact ttatcaaggc tacttatcct 2548441 catctgcgct tttcatattc agccttcgga acggctttcc agctgttcaa gaaggtcgtt 2548501 tgtttttcat ttttttagaa tcatactgcg atgattttcg cttgtgaagc ttgcatttat 2548561 cttttgttga actcatatta cgccgctttg gacgcagtgt caacagcatt ttttaaaatt 2548621 attagacaat tttgattaat caatctatat tgtatacgct ttcattattg gtacaaaagg 2548681 aattgcaaat gttaaaagtt tttataattt ttttattaat ctatcaagaa tacaccagaa 2548741 ttatttaatt ttatataaac atggaagatt ttataacacg atatggttcg tatatggatt 2548801 gagtctgaca gatcatcttg caatccattt caatttcgga taggcacttc tcttgttccc 2548861 tcggcataca ttaatgatat cttgcaaaga aaaggtgata cgatgaataa atcatttgca 2548921 gacatgcaag gatttcctgc gggctttcca agcttcccca actttccgca gcagtactat 2548981 cctgctgtcc ctccctttta ccagcaaagc cagcagccat ttggaggcta cggatacgga 2549041 cagccgttca gtcaggcata cagcccgtta accactccct ctggaatgta ctcctcattc 2549101 ccatacgctt caggatttta cggacagcaa ttttcaggtg caggctttag cggccatggc 2549161 ggcagcttaa gtgctccagc gatacatgcc ggcggattca gcggggcgcc aggcgtacac 2549221 ggaggcttta gatattaaag aataccacaa gggccgaaca tctattgcgg tccttttatt 2549281 gttttaaaac gacttcacaa gtacagtcac attttctgtc tttatatttg gaaacaggat 2549341 ggaatatgat taagatgaat tgaacgatat tctgcacaat ccgtaagttt tcgaggagga 2549401 ataaaattgc atataaaaat agacgattta actggacgtc aggtggtttc actggtgaat 2549461 gagcatttac atagcatgac gcttatgtcc ccgccagaaa gcattcatgc cttaggtcta 2549521 gaaaaactaa gagggcctga aataacattt tggagcgcat gggaaggtga tgaactagct 2549581 ggctgcggag cgctaaaaga actggacacc cggcatggag aaatcaaatc aatgcgaaca 2549641 tctgcatcac atttaagaaa aggcgttgcc aaacaagttc tccagcacat cattgaagaa 2549701 gccgagaagc gaggctatga gcggttaagc ttagaaacgg gttcaatggc ttcatttgag 2549761 ccggcaagaa aattgtatga aagcttcggt ttccagtatt gtgaaccgtt tgcagactac 2549821 ggtgaagatc caaacagtgt gtttatgacg aagaaattgt gagacggctt tataaggata 2549881 gataagtgca ggggaaggtc tgtcttatct atcttttttt atattcacac atttttcacc 2549941 tttatgatac acgccaatgt tttcaatttt gtttaattca aagaacagcg ggaattacaa 2550001 acgacatgaa cgatatcatg caaattcata aaggaggaga ttgatatgaa aagcatagtt 2550061 ggtgtatatg aaactccgca ggaaaccatc gcagcgattg aaggcttact tacaaaaggc 2550121 tatgattctg atgacatttc tgttgtgaca agccggcgag atacagatta tttggagtca 2550181 cgtacaggaa cagaagtcaa tcaagctatc gatgcacatc aggacgaatc tgaatctttt 2550241 ttcgataaac tgaaagatta tttcacaatg gatgatactg ctacacacag caaagcatta 2550301 tccgacttgg atattaaaac tgatgaaata gacaagtatc aagaagattt ggatgacgga 2550361 aaacttctgg tagccgtcga tacagatgca gatgtaattg ctcctattga taacggcaat 2550421 gccctttcag gcggcttttc aagcacaaat gaattggatt atacaacgaa agaagaaaaa 2550481 acgatgccgc tccgggaaga acagctgaag gtcgataagg aagacgttca aaccggcgaa 2550541 gtagaaatag gaaaagaagt gaaaacagaa aaaagagata tggacattcc ggtgagacat 2550601 gatgaaattt atgtcgaacg ccgtccagtg gatgaaaata aaacggacgc tgctcccgtc 2550661 aacgattcgg aagagatcag agttccaatc gttgaggaaa agctggaagt gactaaaaaa 2550721 ccggttgtca ctgatgaagt ggttgtcggc aaacgcactg ttgaagaaaa tgaacatatt 2550781 tctgaaactg tgaaaaaaga agaacctcgt ctgaataaag aaggaaaagt tgacggcttg 2550841 gatgatgatc cgttaaataa caaatgaaaa tcatagaccg acaacaaaaa acctcaaatc 2550901 ctaaatggat ttgaggtttt tcttttggta cgtcccagga gagattcgaa ctcccgaccg 2550961 acggcttaga aggccgttgc tctatccagc tgagctactg ggacacgttt tgtttttttg 2551021 tttttcgctt taactatcag cgacaagatt tattatatat gggatgcaat aataagtcaa 2551081 cggtttttta gaattttttt catgaggaag aaaattttct tcctcatgac attttcatag 2551141 tgtgactcga ttttgcagat cctcaatttc attgcctgct tggtcgtaaa aacggactgt 2551201 cgcagcatca ttttctaatg tcagtatagc atagctttct gtcctgcgca ccctcggaag 2551261 ccggatgctg cctgggttaa tcatcagttt tccgcgcagc acttcgcttc ccgcgatgtg 2551321 cgaatgcccg aagcagataa catccgcccc gagctcctct gcacgatagt atacgtttaa 2551381 caaggtctgt tttataccgt gaaggtggcc gtgtgtgact agtatttttc ttgagccggc 2551441 agtcagaaga agctcgtcct taaaatcgcc ggcaaaatcg caattgcctt ttacaaccgc 2551501 ataaggctcc aatgcaggat gcctcgtctc aagctcagag tccccgcaat gaatcatgag 2551561 atcaacttct gcctcatgcc gtttcgcaat ggtttggagt tcttcttcaa gcccatggct 2551621 gtcactgata atcagcacgt tcatgtacaa gcttcctcct tatgcctcca aaagcttaga 2551681 cagcttttta agcgcgtcag ccctatggct gattttattt ttttcatcac ttgtcagttc 2551741 agccatcgtc ttatctttat ctttcacgat aaaaattggg tcatagccaa agccatattc 2551801 tcctctcggt tcttcagcaa tatacccttc aacatggcct tcgactgttt ttgtttcctc 2551861 tccgggaata ctcacggcca gtgcgcagcg gaaacgggcg gtgcgctgtt ctttttcgat 2551921 acctttcagc tcgctgagca ctttttcgat atttgcctgg tcgtctttct gttcccctgc 2551981 atagcgggct gaataaaccc cgggtctgcc gccaagatta tcgatggata gtccggagtc 2552041 atccgcaatc accattttgt tcactgcttt ggcaacagct tccgctttca taatggcatt 2552101 ttcttcaaat gtatggcctg tttcttcaat ttcctctgtg aatccaattt cagctaaaga 2552161 tttgacatca tagcctcttg gctcaagaat ttctttgaat tccttcactt ttcccggatt 2552221 atgtgttgca ataattgctt ctttcatgat gatcaagcct ttctgtcttt atttcagttc 2552281 tggcagagaa tcacccagca cttctttttg cttgtcaatc agctcttgga ttcctttttc 2552341 cgcaagaccc agaagaccgt tcagatcctc tctagaaaaa gttgcctctt ccccggttcc 2552401 ctgcaattcc acaaaacggc cgctgcctgt catgatgaca ttcatgtcaa cttcagcaga 2552461 ggaatcttct tcataattta aatctaacaa aattccctgt tccttatcaa ttccaacaga 2552521 gattgcagca agaaaatcag tgatcggatt tgtcttgatt gttcctgctt tgatcagctt 2552581 gccaatcgca atcgccatag caagaaatgc gcctgtaatg gaagctgttc tagttcctcc 2552641 atcagcttga atgacatcac agtcaatcca aatcgtccgt tcaccgagct tttccagatc 2552701 tacaacagct cgaagcgcgc ggccgatcag gcgttggatc tccattgttc tgccggaaat 2552761 tttcccctta gaagattctc tgattgttct ttggtttgtt gcccgcggca gcatgctgta 2552821 ctctgctgta atccagcctt tccctccgcc ccgcaaaaac ggcggtacgc ggtcctcaac 2552881 agacgcgttg cagattacct ttgtatttcc cgctgttatt agaacagaac cttccggatg 2552941 gctgataaaa tccaaatcga atgtgattgg acgcagctca tcgtgttgtc ttccgtcatg 2553001 tctcatgttt tacctccgat tgtatgtaca taaaccattt ttgtcccgga attgaataaa 2553061 gaaagaggca gccggaacgc taacctcttt cttcctagta tatcaaaaat cccaatttaa 2553121 aaactacccg tattcacttg agatggtctg gagaccggtt ctgtgagctt ttcgcctttt 2553181 tcatttacca gctctgattt tccgttcact ttaacagaga cgctttttac atccggctgc 2553241 tccgttaacg tcagcacaat gctgttcagc acttctgaag aaatcatttt cgtcttctca 2553301 tcggcgctgc cgaatataga ttgattgaaa tccaacgtca cgcgcccgtc tttgattttc 2553361 ggtttgctga ccagctttac atcttcactg aagtctgtta acagcccgct caccttgctc 2553421 ggccctttag ccaattcatt aatggctgct gtgatgtcgt ctttttccga attgtcgatt 2553481 cgtttggtca ccggcacgta gtattcactg tcttcatttt ccgccaaata gtagactgtc 2553541 agcggatggg tagcagtgag atcatttaca ccggctgttt ccaaattaat gccgtctttg 2553601 cggcttaaat catctgagat cggcgtccct cctacaggca tctccttcag ttcatgcccg 2553661 tttattctca gcttcacttt atctatcgaa ctaaattgcg tcagcgtcca cgtcacagat 2553721 tgaacgattt tctgttcgtc ttctttctta taatttttga actcattaga gaaatcagct 2553781 atcgccgttc catctttttt gatgtcaacg ttaacggtgg tgtcagccgg caatacagct 2553841 ctgaagccat tcggaagaat ttcagacaca ggcccgccct gtacgaggta ttcaagcgcc 2553901 tgcttagccg tgctctcact tttaggaaga ggcagcgttt gcgcaacaac atacccgttt 2553961 ttatcaatga gataaagctc cctcataaca gtagatgagg cttgatccgc ttttgcggta 2554021 tcgctttttt cactttctgt ttttttggct gctgttgtat ttgaattggc acccgcttca 2554081 tcgttcacga atgtaacgtc ttgaggcgga tcaatttcct cggctgcctt atcagattga 2554141 aacaaaccgc atccggataa aagcaaggca gaggtgagac aagtggcacc aatgactgca 2554201 ggtccttttt tcagcatact tttccctcct aaggatgttt gtactattat gtatacgagc 2554261 ctctttagga aatagaccga agaattccgg caaaacagaa aaaaacccgc aacataccgt 2554321 tgcggggaaa actatctttt aatcggttct tgcagtgaga tacattccac atgcccgact 2554381 tcatggccaa accaatcgtc tgcgattttt gcaaactgat cacgcgcccc tgttgtcagg 2554441 aactgatgat ccggggcaat cggagactgg ttcagcagcc ctttataaga gagaattgtg 2554501 ctgacttccc gggctgtttc atcgccggac gaaataatgt ttacgtgctc tcccatatat 2554561 ctttgaatgg cttcttttaa aatagggtaa tgggtgcagc ctaaaatcag cgaatcaatt 2554621 gatgtgtctt ttaacggata cagcgaggtt ttaacaatct cgtctgctgt tttgtcgaga 2554681 aacttcccgc tttccacaaa aggcacaagc agcgggcagg caaggttttc aaccttcaaa 2554741 tcagggttta atgccaaaag cgcttcttcg tatgcattgc tcttaatcgt attctctgtg 2554801 ccgatgacac cgatatgctg attatccgtc acttttatcg ctgctctcgc accaggctgg 2554861 atgactccga ccaccggtat accgacgctg cgctggatgt catccaaagc gatcgctgtt 2554921 gctgtattac aggcgatcac gagcattttg atgtggtggt tttcgagtaa ataattcgtc 2554981 agctcccacg tatattgaag cacctcttct tcagggcgcg gcccgtaagg acaccgtttc 2555041 gtatccccga cgtagataat attttcttta ggtagctgtc tcatgatttc cttcgcaacg 2555101 gttaaaccgc caaccccgga atcaatgact cctattggtt gttccaacaa aatcgcctca 2555161 ttttctcttc atttcatgct gcagtttcat caaagatttt tcgaagatgg ctatttcttc 2555221 atctgtaaac gattcgaaca tatcacgcag atattcctgt ctttttgtaa tgacctcttg 2555281 gataatccgt tctccttcag gcagcagatg tatcctgaca acacgtctgt ccgccgggtc 2555341 cttgacccgc tcaacaagct catttttttg catgcggtcg attaagtccg ttgtcgtgct 2555401 gcatgccaga tacattttgc ccgataattc accgattgtc atatctccta attcataaag 2555461 ccattgcaag ccgacaaatt gcggcggcgt aatcgcatat tggttaagga tttctcgtcc 2555521 tttttgctta atgatcgcgg caatgtggcg gagtgacttt tcaatatccg caacatgctc 2555581 caaaggtttt gatgtcattt gtccatccct cactcaagga tctcttacgc acaaaagcgt 2555641 tccgtgtcta ttttccttct tttttgaaga aaatgcaaga ctcgcaggag agaaatagag 2555701 gactttagtc aaacaacatc aagaaataaa atttaattta tgacttgcct acgttttgca 2555761 cagcattcca aatatggttt cgaatgttcc aaacaaacag caataaccgg ctccttccaa 2555821 aagaaggaat accggcaagg attaaagctc tagctcaccc attctaagaa gctcaacaac 2555881 ggcttgcgaa cgccctttca cacccaattt ctgcatggca tttgaaatat ggtttcgaac 2555941 ggttttctca ctgataaata gctcgcttgc aatctccttt gttgtcttat cttgaacgag 2556001 caattcgaac acttctcttt ctcttttcgt tagcagcggc ttcgattgaa attctttctc 2556061 cttcaagtat tgtaaccctc cttgctaagg tgagagcgaa tcagaaacga atgggttttg 2556121 atatagtcga gatatcatat gtaagaaggg cgcaggaggt gacgtttaca agataattag 2556181 tttatcgtgt atgaagaagc gtttctttct cctcatccgt ccagctgaca gccttgccgc 2556241 tttcctttga gacttgaacc atcacgactg ccccggtgaa gcagggttcg ccttcgaggt 2556301 tctctccgag atagtgcaag gtaagagatg aactgccgac tgcgcttgtt ttcacataga 2556361 tgcgcaactc ttcataaggc atgacttggc gcaaataatc gcattgctgg cttgccacga 2556421 ctgtcatggt ctgtttgttt tcactcatca tattcagctt tttaaaataa gaaatccgca 2556481 cctcctcaaa atatataaaa ggggttacat tattcatatg cccaaacatg tctgtctcgg 2556541 aaaatcttac ggatacctta ttgaaaaaag aaaaggatgt tttccattct tgaaacggca 2556601 tatcaatata agcgggaagc ttcatctttt ttcatctcct tattgtttaa aaaaacctct 2556661 cccatgcgga agaggttttt tcttcttata ctctgtcgct tccgaagaaa ttgcggaacg 2556721 cttgtaagtt tgtatctcta ttcaaggctg caatcgaagt ggtaagcgga atccccttcg 2556781 gacaggattg aacacagttt tgcgagttgc cgcaatctgc aaggccgcct tcatccatta 2556841 atgcttctaa tcgttcagat ttattcatgg cgcctgtcgg atgcgcgtta aacaggcgga 2556901 cttgcgacat cggtgcaggc cccatgaact tcgatttgct gttcacattc gggcaagctt 2556961 cgaggcagac gccgcatgtc atgcattttg ataattcata tgcccattga cgacgttttt 2557021 ccggcattct cggccccggt cctaaatcgt acgtaccgtc aatcggtatc cacgctttta 2557081 cttttttcaa tgaatcaaac attctgctgc gatcaacctg caaatcacga acgactggga 2557141 atgttttcat tggttttaaa cggattggct gttcaagctg gtcaataagc gccgtacaag 2557201 actggcgggg ttttccgttt ataaccattg aacatgcgcc gcatacttcc tcaagacagt 2557261 tcatatccca tgtgacaggg gttgtcttct cacctttgac attaaccgga ttccggcgga 2557321 tttccatcag agcggaaatg acgttcagat tcgggcggta tggaatctca aattcttcat 2557381 cataaggcgt gctgtcagct gtatcttgac gtgtgataat aaatcgtatg gttttttgtt 2557441 cactcatgat tatttcgcca ccttcttctt cgagtaatcc cgtttccgag gcgttatcag 2557501 tgatacatcg acatcctgat actcaaattc cggcgcttca tacgggctta catgtttagc 2557561 cattgttgtt ttgagccatt catcatcatt acgttcagga taatccggtt tataatgggc 2557621 gccccggctt tcattacggt tgtatgcgcc aagggtaatc accctcgcaa gctgaagcat 2557681 gttcgagaac tggcgtgtga acatcgctcc ctggttgctc cattttgtcg tgtcattgat 2557741 gttgatcttt ttgaagcgct ccattaactc ctgaattttg tcatccgttt tcaaaagctt 2557801 gtcattatgg cggacaaccg ttacgttcgc cgtcatccac tcaccgagct ctttgtgaag 2557861 aacataggca ttttcggttc cgtccatact cataatatca gcccattttt cttcttcttt 2557921 cttaacgtga gcgtcgaata aagatgaaga catgtcttcc gctgaagatt ctaagccgtt 2557981 tacatatttc accgcattcg gaccggccac catgcctccg taaatcgcag acagcaggga 2558041 gttcgctccc aagcggttgc cgccgtgcat agaataatca cattccccag ccgcaaacag 2558101 tccagggata tttgtcattt gatcgtaatc cacccataaa ccgcccatag aataatggac 2558161 cgccgggaag attttcattg gaagcttacg cgggtcgtct cccatgaatt tctcataaat 2558221 ctcaatgatg ccgccaagct taatatcaag ctctttcgga tctttatgag acagatcgag 2558281 atataccatg ttttcaccgt taataccgag cttctggttc acacacacat caaatatttc 2558341 gcgtgtcgca atatcacgcg gcaccaggtt tccgtatgcc ggatattttt cctccaggaa 2558401 ataccatggt ttgccgtctt tatatgtcca cacgcgcccg ccttcaccac gcgctgattc 2558461 actcatcagt cttagtttgt catcgcccgg tatggctgtc gggtggattt gaatgaattc 2558521 tccgtttgca taatacgctc cctgctgata aacgattgac gcagcagatc ctgtattaat 2558581 catggagttc gttgattttc caaagatgat tcccggtccg cccgtcgcca taatgacagc 2558641 gtctgaacgg aaggattcaa tttgcatgtt tgtcaggttt tgtgcaacaa ttccgcggca 2558701 ggttctgtca tcatctaaaa cagcgccaag gaattcccag ccttcgtatt ttgtgaccag 2558761 acccgcaact tcgtatctgc gcacttgctc gtccagtgcg taaagcagct gctgtcccgt 2558821 cgtcgcacca gcataagcag ttctgtggtg ctgtgtaccc ccgaatcggc ggaaatcaag 2558881 caggccttca ggcgtccggt taaacatgac gcccatccgg tctaataagt ggatgatcga 2558941 aggcgccgct tcacacatcg ccttgaccgg cggctggttg gcaagaaagt ctcccccgta 2559001 taccgtgtca tcaaaatgtt cccacggaga gtcaccttcc ccttttgtat tgaccgctcc 2559061 gtttatgccg ccttgcgcac aaactgaatg agaacgtttg acaggaacga tggaaaacaa 2559121 tttaaccgcc attcctgatt ccgctgcttt aattgtcgcc atgaggccgg caagaccccc 2559181 gccgactacg ataatgcttg attgactcat gatagcccct ctccctctag taatctagta 2559241 ctcttaaaca aatgcaaaaa tcgcttttaa gcctacgtat gacagtgcaa caaaaataat 2559301 cagcgtaacg tatgtcgaaa ttctttgaga acgaggcgtt accgtgatgc cccatgtaac 2559361 agcgaaagac cataaaccgt tcgagaagtg gaaaattgtt gataaaacac cgacaatgta 2559421 aaaaccaagc atagccggag agctcaaaat attcgccatc atgtcgaaat tgacctcagc 2559481 acccatttgt gcggcaatgc gggtttccca cacgtgccag ctgacgaaaa tgagggtgat 2559541 gataccggtt acacgctgca ggacgaatag ccagtttctc atgtagctgt attgaccggc 2559601 gttatttttc gcagtaaacg ctatgtacac accataaact gcatgataaa ttaatggtaa 2559661 gaagataata aaaatttcca aggcatacct gaaaggcagg ctatccataa aatgagcagc 2559721 gctattgaat gcttcagcgc cccttgcggc aaactggttg acgactaaat gctgaataag 2559781 aaagatgccg accggtatga cgccaagcaa ggaatgcaat cttcgaaaat aaaactctct 2559841 gttcccagac attactttac cccctgtttg ataagtgcga aatgtgctaa atctcttccc 2559901 ccacttcttt caattgtaag cactttatta agatttattg acaatttcat tttactcctc 2559961 cctcaaaagg gcgtcaagaa aacgcgtaca taaattataa ttttccgaat tgattagttg 2560021 attgaaaaat tttattttat caatatatat ttcttgctta atttttcata agaattacag 2560081 gatcattctg taatcctccc ccctgtttga gctataatat acgcaggaga gaggggagac 2560141 agatatgaag tctaaatttg aagcatctat tgacaaccta aaagaaattg aaatgaacgc 2560201 ttatgcctac gaactaatac gagagatcgt tctcccagat atgcttggcc aagattactc 2560261 ttccatgatg tattgggcag gaaaacatct cgcccgtaag tttcctcttg aatcatggga 2560321 ggaatttccg gccttctttg aagaagcggg ctggggaacc ctcaccaacg taagcgctaa 2560381 aaaacaggag cttgaatttg aacttgaagg gccgatcatt tccaaccggc ttaagcatca 2560441 gaaagaacct tgctttcagc tggaggctgg ttttatcgct gaacaaattc aattgatgaa 2560501 tgatcagatt gccgaatcat atgaacaagt gaaaaagaga gccgataaag tggttctgac 2560561 tgtgaaatgg gatatgaaag acccagtgta atcaaaaagg cggtgactgc atagtcccgc 2560621 ctttttgatt gtcattacac agctgaaggg tgttttgaaa gctcaaatgc atcgtgaagc 2560681 gactcgactg ctttcaccat gtcattttcg cttacgactg ttgacacttt gatttcagat 2560741 gtgctgacca ttttgattaa aatgtttttt tgcgccagta cagcaaacat ttcagccgct 2560801 acaccgggat ttgagaccat gccggatcca acaatagata ctttagccaa tttgctttct 2560861 gtctcgattt tctcaaattc cagcgcgtct ttatactctt caagcaccgc aacggtttgg 2560921 tctgcatctt ctgttttgac agagaaggaa attccagtct tgtcctcggc ctgcgtttgg 2560981 ataatgatat ccacgtttat gtttcttttg gcaagtgttg taaaaatagt agacaaagtt 2561041 gtcaggccgc tagtcagccc gtaaatggtt actcttgtga tttgatcttc aaatgcaatg 2561101 cctctgacaa ttaaattctg ttccatggat gattcctcct caattaatgt tcccgcttcg 2561161 gtttctgtac ttgaacgcac ttctaacggc acttggtaat ttttcgcgaa ctcaactgct 2561221 ctcggatgaa gaacaccggc gcctaaattg gcaagctcaa gcatttcatc gtatgagatg 2561281 ccctcaagtt ttctcgctga tttcacatag cgcggatcgg ttgtaaacac gcctggcacg 2561341 tctgtgtata tgtcacattt atcagctttt aaagcggcag ccaaagcaac tgctgttgta 2561401 tctgaaccgc cccggcccaa tgtcgtaatt tcacaatcct ctgtcatgcc ttggaatcct 2561461 gcaacaatga caatttttcc tttttcaagc tggtctgcta aaaccgaagt gtcgatatct 2561521 gtaattctgg cgtttccgtg aatggcctcc gtacggattc ccgcctgcca gccagtataa 2561581 gacacagcgt catagccttt ttcctgcaat gccattgaaa ggagtgaaat cgtgacctgc 2561641 tcgcctgtcg ccagcagcat atccatttcg cgtttgctcg gctggtcaga aatagctttt 2561701 gcaaggctga ccaattcgtc agtggatttt cccattgctg aaacgacgac aacgacttga 2561761 tggcctttct gtttttctgc aattgcgcgg tttgccgcat tttgaatttt ttcgactgag 2561821 ccgacggaag tgcctccgaa tttttgtaca ataagaccca tgtattacca ccctttacat 2561881 tttggttcgt gcgggtgagg agaaagagcg ctttgtccac aataaaaaaa gcaatgagag 2561941 gaatactctc attgcttatc aattaatcat cataaatgat tatgaacaac gagatagccc 2562001 tccaagaaaa tgatttcttg acagccttac atttattcaa tgcacggcca gcaaataata 2562061 ccgatggggt tttatttgct tcggcgacgc tcccctttca gcctttttca cagaatccat 2562121 ctttctccaa aggcatactc ttgaagttcg cacctctatc ttcaccatat aacacgatct 2562181 aactatgaaa ttagttcaca ttttatcaga tcttatttaa aaggacaaca ttatttttgc 2562241 aatttgtcgt aaaggagctg agccgccgct gcgggaacac cggctttttt gatgtcctca 2562301 aggcttgctt ccttcatttt tttaacggaa ccgaaatgct ttaacagcat tttctttctt 2562361 ttctctccga tacccgggat gtcgtccaaa acggattgaa acgcgctttt tccccggatt 2562421 tgcctgtgaa aactgattgc aaaacggtgc acctcgtcct gaatgcgctg caggaggtaa 2562481 aattcctggc tgtttcgttc cagatacgcc acctccagcg gatcaccgat cagtaaattt 2562541 gaggttctgt gtttttcatc tttcgctaaa ccggcgatcg ggatatccaa gccgagttca 2562601 ttttcaatga catcccttgc tgcgttgatc tgcccttttc ctccgtcaat gataatcaga 2562661 tcgggcagcg gcagattctc acgaagcact ctcgtatagc gtcttctgac aacctctctc 2562721 atagaaccgt aatcatccgg ccctgtaaca gttttgattt tatatttgcg gtattccttt 2562781 ttgtatggtt tgccatcgat aaacacaatc atcgcggaaa ccgggtttgt cccctgtata 2562841 tttgagttat caaacgcttc aattctgtgc ggcgtataaa tatttaatgc ctcacctagt 2562901 ttctgcactg ccccgattga acgctcctcg tcccgttcga ttaaagagaa tttttctttc 2562961 aatgcgattt tcgcattttt atgggcaagc atgagcagtt cttttttcgg gccttttttc 2563021 ggctggtgaa cgtttgtttc cagtagctgc tcgatcatag attgatctat gctgtccgga 2563081 actaaaatct ccttcggaag gaagtggttg ttttttgaat agaactgccc gatgaacgtg 2563141 aggaactctt catctgcttc ctgataaagc gggaacatgc tgacatcgcg ttcaatgagc 2563201 tttccttggc ggatgaaaaa gacctgcacg cacatccagc ccttatcgta cgcgtacgcg 2563261 aacacatcac ggtcgactag atcgttcatc gtcatttttt gtttttccat cgttgattca 2563321 atatgggcaa tttggtcacg aagctctttt gctcgttcaa actcaagatt ctcagcagct 2563381 tcatgcattt tctcttcaag ctcttttttg acctcattat agccgcccct taagaaacgt 2563441 gtaatgcttt caaccagctc tctgttcgtc tcttcggaaa tatcctttac acacggagca 2563501 aggcattggc ccagatgata gtaaaggcac actctgtccg ggagcttgga gcattttctg 2563561 agaggataca gacggtcgag cagttttttt gtttcccttg ctgcctgtac attcggatac 2563621 ggcccgaaat agcgcccttt gtcttttttg acattgcggg tgacaatcag ccttgggtgg 2563681 cgttcatggg tgagttttat gaaaggatag gttttgtcgt ctttgagcat gacgttgtat 2563741 ttcggatcat gctttttgat cagattcatt tctaaaataa gcgcttcaag attggaggac 2563801 gtcacaatat attcaaaatc ctcgatttcc gtcacaagcc tttgggtttt cgcgtcgtga 2563861 gaaccggtga agtaggagcg cactctgttt ttcagcactt ttgctttccc tacgtagatc 2563921 acagtctgct gccggtcctt catgagataa caacccggtt gatcaggaag gagggcgagt 2563981 ttttctttca gttgtttgtt catatgttac ccttccttat gtttaatcct ttatttccag 2564041 tttaacacga acgtttgttt ttctctatgg ttcacaattg gcgaataaaa aaagcgatcc 2564101 ctcaatcgga atcgctctgg catgtaagca gcggaaaatt aaagatgttt gtttacaagc 2564161 tcttgaagcg cttcttttgg tttgaagccg actgaagttt caactacttc gccgtctttt 2564221 aacacaagaa gagtcgggat gctcataacg ccgtattttc cggcagtttc ttggttttcg 2564281 tctacatcga tttttacgat tttcagtttg tctcccattt cttgatccaa ttcttcaaga 2564341 acaggtgcaa tcattttaca aggtccgcac caaggagccc agaagtctgc cagtacgacg 2564401 ccttcgcttg tttcagctga gaaagattga tcagttgctt ttacgatagc cattattgaa 2564461 ttcctccaat gtgaaatgat gatttttagt atagcatctc ccattcgttc acgctatttt 2564521 aatgcttaca aattattttt tcctgatcac agccggttta ctcattttta tatggttgaa 2564581 tgggatatgc tcttttttta aaacacaaat ctgataatgg ccccgatcac tacaattgcc 2564641 ccaataatca ttaaaatggt acgaagcata agatcacatc tcctcttcac tgtcatgtac 2564701 tttaccatgc cctgccggag ctgttttaaa acctgaaaaa gagcgccggc atgaagctcc 2564761 ggcgctcttg cgcgattaag aatcagcacg cagcgtaagt aagacgactg acattggcgg 2564821 gagttttact ttcagtttgt ttttgctgag cgtgtattgt ctgaaggatt ccggtttgac 2564881 atgatgagga tcgtcaaacg tgttatgcgc attcattttt tctgccgtaa gaatgactcc 2564941 ggaatggtcc gctgccttgt gtaggcccct cagctcgatt tccgcctctg ctttgttttg 2565001 gtgatcgatg ttgcaaattg tgatattgat atcgccttca gcttgtttcg acgctgaaat 2565061 gctgatttgc ggaagcgttt caccgttcca ttcatagtcg gcagacattg tctctgtggc 2565121 taaaagagaa gcgtcctggt gcaccttaaa catattgaat acatggtacg tcggtgtcaa 2565181 aagcatccgc tctccctcag tcaaaatcat cgcttgaaga acatttactg tttgggcgat 2565241 gttggccatt tgcacccggc ggcaatgctg atggaaaatg tggaaatgag aagccgccac 2565301 cagtgcatca cgaatggtgt tttgctgata taagaaaccg ggattcgtgc ctggctcggg 2565361 atcaaaccac gtgccccatt catcaataat cagcccgacc cgctgctccg gatcgtaccg 2565421 gtccataatc gtgccgtgtt tttgaatcaa ttcatcgatg tatttggctt ttttcatcgt 2565481 aataaaccat tcatcttccg tgaattctgt ggctgatcct ttgcccttcc agaaatcccc 2565541 cggaatcgtg taataatgaa gactcaaccc gtccatcagg ccagcggctt ttttcataag 2565601 cacgtccgtc caattaaaat catccacatt tgcgccgcct gcaattttat aaatgtcatt 2565661 cccgctgtaa ttgcggacat aagtctgaaa acgccggtac agatctgcgt agtattcggg 2565721 atgcatgttg ccgccgcagc cccagttttc attgcccacg ccgaaatatt tcagcttcca 2565781 aggctcttct cttccatttt gctttctcca gtctgacatc ggcgtgcctt cttcaaatgt 2565841 catatactca atccactccg acatttcctg aacggttccg cttccgacat tgccgcaaat 2565901 atatggctcg cattcaagca gctcgcaaag catcataaat tcatgcgttc cgaattcatt 2565961 tgattcaatt gtaccgcccc agtgagtgtt cagcattgtc ttacggtcac cgacaccgtt 2566021 tgcccaatgg tattcgtccg caaaacaccc gcccggccac ctaaggacag gaatgtgcag 2566081 ctgtttgagc gcctccagca cgtcctttcg tatcccgttg atattgggga tgtctgagtc 2566141 cgttccgacc cagatcccct cataaatccc tcttcctaaa tgctcagcaa aatgaccgta 2566201 tatatttttg ttaatggttc cttttgcgat atctgtttga atcactgctt gatgttcaga 2566261 catgcctctg atcattcctt tcatacggat atgaaaagca ccacagtcaa atatgtgatc 2566321 tgtcgtttgc ctgaggagtc agcatgaatg taagcgcttt taaagtaacc atattatata 2566381 tgttcgtaca tgtcaacgac attttctatt gtttttatat ttgtacgtat gtatttataa 2566441 atatgaaaaa acccggactt ttaaagtccg ggatttcctt tatgagtgta tattcagctg 2566501 tttgaattcc tcagttaata acgggacaac ttcaaataaa tcaccgacga tgccgtaatc 2566561 cgctatttta aagatatcgg cttcggggtc tttattgatg gcgacgatca ccttgctgtt 2566621 tgacatgccg gccaaatgct ggatggcgcc ggaaatgccg catgcaatgt acaaatccgg 2566681 agtaacgact ttcccggtct gcccgatttg gagagcataa tcgcaataat cagcgtcaca 2566741 tgccccgcga gaagccccga ctgcggcccc tagcacctct gcaagctcct gcagcggctg 2566801 aaatccttcc ttgcttttga ctcctcggcc gcccgcaacg ataattttcg cttcggagag 2566861 atcaacaccg tccgccgttt ttttcacgac ctcttggata acagtgcgga ggtcagtaag 2566921 agaaacatca atgctttcga tgctccccga tctgctggtg tctttttctg aagcttgaat 2566981 gttattgggg cgaattgttg caaagatcat cggatcggtt gaaatgacgc gttcaaaagc 2567041 tttccccgag taaatcggcc gtgtgaacac aacattccct ccggtaacgc ttacatctat 2567101 agcatcagaa attaagcctg tttgcagacg ggcagcaagc ttcggtgaaa gatccttgcc 2567161 cattgccgta tgcccgaaga tgactgaatc aggattttct tgctcgataa cacctctcat 2567221 gacctggctg tacccgtctg ccgtgtatgt tttcagcttc gggtcctcag cggtaagaac 2567281 tttatctgct ccgtaatgaa taagctcttg tgcaatgctt tgtacatttt caccgatgag 2567341 aacaccgatg acttccccat ctcctgaaat ggttcttcct gcagctattg cttcaaaggt 2567401 gacatttcgc aattccccat cgcgtatttc tccaagcacg atcacttttt ttcccattct 2567461 aacatccccc tgtttctttg aatgtccaag ttttaaatga ctttagcttc gctgcggagc 2567521 aatgaaacaa gctcttttgc ctgttcagca ggctcacctt ggagaagctt cccggcttct 2567581 tttttcggcg gcagaaaacg ttcaatggtt ttcagctttg gttcagcatc ctcttcgtcc 2567641 agatcaagat catcaagttc aagctcttca agcggctttt tcttagcctt cataattccc 2567701 ggaagcgatg gatagcgcgg ctcgtttaag ccctgctgag ctgtgacaag caatgggagc 2567761 gtcgttttga ttttttcaac atccccttcg acgtcccttt ctgcttctgc atcagtgccg 2567821 ttgatttcga gtttggtgat cgtagtgata cacggaatgt ccagtagctc ggcaagccga 2567881 ggcgccactt gtcctgatcc tccgtcaatg gcaacatttc cgccgagaat caaatcaaac 2567941 tcctgatcct tcatatagtg gtataaaact tgagaaatgg aatattggtc gggttcatca 2568001 agatcatctt ctatgttgat taaaacagct tggtcacaac ccatggcaag cgccgtacgc 2568061 aattctttct ccgcttcttc accgccgacc gtgacagcgg tgatcgtgcc gccatgcttt 2568121 tccttcagct ggatggcttc ttctatcgcg tactcatcat atggattaat gatccattcc 2568181 gctccgtcat cctgaatctt tcctgtttca atgacgattt tttcttctgt gtcaaacgtc 2568241 cgtttcatca gtacaaatag attcatgatc atatcccctt ttattcgcct ttgaactgag 2568301 gctttctttt ttcgagaaat gcctggatgc cttccttggc gtcctctgac tcaaatgctt 2568361 ccccaaatcg ctttgcttca agctttaagc tgccttcata ggaatacacc ttgttggaat 2568421 aaagaagttc aagcaaagat gccagcgttt gcgggctttt ctctgcaaac ttagcggcaa 2568481 gtgcttttgc tttttcaatc acttctgcct catctttcgc tccaattgag acaagtccga 2568541 gatcaagcgc ttcttttccg gatatcggtt ctcctgatcc gatgagctcc agtgctttgg 2568601 ctgtaccgac atatctcgga aggcgctgtg tccccgcaaa acctggaatg ataccgagat 2568661 taagctccgg gagccccagc ttagcatctt ctgccgcgat tctgatgtga caggccattg 2568721 caagctccag cccgcctccg agagcagcgc cgtgaatcgc tgcgataatc ggttttggaa 2568781 aactttcgat tctctccatt aactgctggc cgcgctcagc gagcaatgag gaatcctcat 2568841 tgcctttaag cgatgtaaat tctttaatat cagcgccggc tgagaaaaat cttccctcgc 2568901 cgtgaatgat aatgcttcgt acgcctgcat ctgtctcaca ttgatcaaga caggaagaca 2568961 gctcttctaa tatccggctt gaaagcgcgt ttgccggcgg attgtgaatc gtcaagactg 2569021 ccacaaattg atcaaccgca agtgaaattg cattcatagg acagaactcc tttacttatt 2569081 gtgaattccg gataccaata attctaaaac gctgtttgaa agcgcaacga gatcgtactt 2569141 ttggtcattc atcacccaag ttgtcacagt ttcgtcaatc gttccaaaaa tcatctgccg 2569201 ggcgaggcgg acatcgaggc cttcttttat ttcgcctgat tgtatacctt ccgtcaaaat 2569261 gccatccaaa atatttaagt agccttttaa tatttcgttg attttttggc gcagctccaa 2569321 gttggattgg cggagctcaa gctgcgtgac aatggcgaga ttatggtcac ccgctaaaag 2569381 ggaaaaatgc tttgaaatca caagcgccaa tttctctttc gctgttgctt tttctttaat 2569441 gtcctcttcc atccgctcaa taaattgacc cattttttct ttgaaaagag aaattaaaat 2569501 atcttctttg tttttaaaat agagatagat ggtgccgtcc gctaccccgg cttgtttggc 2569561 aattttggat acctgtgact ggtggtagcc gttttctgca atgacttcta ctgctgcatc 2569621 aataatctgc atatactttg gccgtttttg cttcaatgtt catcgttcct tcctatagaa 2569681 atgaatgact attcattcat aatttcatga taagaaggat tttcaggttt gtcaagttta 2569741 ttcataggcg ttctcttttt ttatttgata tgatgatttt cggtttcttc ttcaagtaaa 2569801 cgccttctta aaatttttcc caccgccgtt ttcggcagct cctttctgaa ctcataggct 2569861 ttgggcacct tatagggagc tagacgtgat ctcgcaaaag cgtccagttc ttctgtatcg 2569921 gcttttgcgc ctttctttaa tacgacaaat gcttttactg tttctcccct gtaggaatcg 2569981 ggaacgcctg cgacaacaat ttcctggatg gcttcatgtt cataaagcgc ttcttctacc 2570041 tcacgcgggt aaatattgta accgccggca atgatgatat ccttcttcct gtcagcaata 2570101 tagaaaaagc cttcttcatc catatagccc atgtccccgg tgaacagcca gccatctctc 2570161 agcactgcgg cggtttcctc tggtttattc cagtatcctt tcatgacttg cggacctttt 2570221 acaatgattt ctccatgctc atacggagcg gcaagctcac ccgtctcttc agaatagatc 2570281 gcagcgtccg tactcggcca aggacagccg atactgcccg gcttgttttt tccccagata 2570341 aagttggcgt gcgtcactgg ggatgcctca gacaaaccat agccttccac aagctttcca 2570401 ccagtcacct tttcaaattt ctgctttacc tccacgggga gcgcggctga tccgctaaga 2570461 cagcttttaa tggatgacag atcataatgc tgcaattcag ggtgatgcaa aaggccaatg 2570521 taaattgtcg gtgcgccagg aaagagcgtc ggtttgtgtt tgtcgatgat tttaagtgtt 2570581 tcgagcggat caaacttagg aagaagaatc atttcgaagc ctagtttaat cgaatagttc 2570641 atgactgccg tcagtccgta gacatgaaaa aatggaacga tgcccagcac tttttcagcg 2570701 ccttctttca cgtcatacat ccaagcggcg cacatttcag tatttgccaa aatattttgg 2570761 tgcgtgagca tgaccccttt tggagctccg gttgttcctc cggtatactg gaggacagcg 2570821 atatcatgct caggatcgat cttcgggatt gtcaggagtt cagttttttc ctgcttcata 2570881 caggaagcga acgtgtgaat gttagctgtt ttgtcaaagt cgatatgcac tttttgtttt 2570941 tgcgtcagcg ggtaaagaat atttttcgga aaaggcaaat agtcttttac actggttatc 2571001 aaaatctggt cgactattga taacgttttc atttttattg ccttcgggaa aagcaaatct 2571061 aaggtgatga ttacacttac ctgagcatct ctaagctggt attcaagctc atgctcggta 2571121 taaagcggat tcgtctgcac cacgatgcca ccggcaaaca agacgccata ataagaaatc 2571181 actgtttgcg ggcaattggg cagcataaca gccactctgt ctcctttttg caggccattg 2571241 cactgcaaaa aagctgcaag tttaagagca tccgtcagaa tgtcatgaaa ggtgagtttt 2571301 tttccataaa acgatattgc ggttttatca gggaatcgtg cggcggagtc tgtcaggatg 2571361 gattgcaggg ttttattcgg caacggaagc tcatgcggga tatcgttggg atactcggca 2571421 agccacggct tttgagactg cataaaacct cccctttcga ttttagagat ccaccttatc 2571481 attatagcag atggacggca aaaaaaagaa aaagaaaggt aaatctttct ttttctcata 2571541 atatgaacag atatataaga ccaattaaca aaaagattcc cgctgcggcg agcagtattt 2571601 tcgcaagctt ttccatctat tctccgtccc cttatattcc ggctgccacc acaaaagaaa 2571661 gcccgacaga aatgacaaat gaaataaagc cgacagcccg gttatcattt tcgatttcct 2571721 gatcaatttt aaaccgcgga gtcaaaaact caaaaataaa gtagctgatc agaagcataa 2571781 caaacccgta aacgccccag ccgatcattt gcagcagcga attatgctgg gagatggaat 2571841 gctgaaatac gtttgcgatt cccaaaattt ttccgccggt cgccattgcc accgcaagat 2571901 ttcctttttg aatctcttcc cagtttttat aagccgtcac cagctcaaac acagtcaaaa 2571961 agaggacgag gcagagaacc gcgacactgt aatatgccgc gatttccaca agctcgtttt 2572021 cccaaaaatc actcatggcc atactccctt ttattttagt tcaacaaccg taacgcctga 2572081 tcctccctca cctgcttcac cgaaacggga acttttgacg ctgcggtggt ttttcagaag 2572141 atcctgtacg ccttttctta aagcgccggt tccttttccg tggatgattg acactcttgg 2572201 atatccggct aacaccgcat catccaagta tttttcaacc cggctgaggg cattttcata 2572261 gcgttcgccg cgaagatcaa gttcaagcga tacgtgatag tcctttcctt tgaccgctgt 2572321 aatcattttt tctttttttg gctccggagc tgatttgata aactccagat ctttttcttt 2572381 tactttcatc tttaaaatac cgatttgaac gttccattca ttgccgcctg ttttttcgag 2572441 caatgttcct ttttgcccga aagtgaggac tttcacctcg tcgccaggct taaagtcgcg 2572501 tttttgcgtt ttcggctttt ccggtttctt ggacttttca aaagcaggca tagcgccttc 2572561 taaccgtttc ttcgcgttaa tcagctcgtg atccttgaag gatttgtgtt cttcttttat 2572621 ggtgcgcaat tcatgaataa tgtcctcggc ttctttcatt gccgctttta ctttttcagc 2572681 agcctgctgt tctgcctctt caagcatttt gtcttttttg ctgttaagct cgatgatttg 2572741 ctgctgcagc tctttatgca gtttttccgc ttcttttctg attgattctg tctcagaaag 2572801 ctcttcttcc gcacgttttt tgctttgttc cagcgacgca atcatcgtat cgacttcgtt 2572861 atgctcggcc gtcatttctg acttcgcctg cccgatgata tggtccggga gcccgaggcg 2572921 ttttgaaatt tcgaaagcat tgcttcgacc cggcacacca attaaaagtt tataggtcgg 2572981 tgacagcgtt tcgatgtcaa attcaacgct ggcattcatg acgccttctc tgttatagcc 2573041 gtacgccttc aattccggat aatgcgtcgt agctaacact cgtgcattgg tgcgatgcac 2573101 gtcatccaag atgctcatgg cgagggccgc cccctcctgc ggatctgtcc ctgcaccaag 2573161 ttcatcgaaa agcacaaggc tgttttcatt gacctgttct aaaatgccga caatattcac 2573221 catatgggat gagaacgtac ttaaactttg ctcaatcgac tgttcatcac cgatatcagc 2573281 gaatacgtgc tcaaatactg ccgcttctga cccttcatct gccgggatat gaagacctga 2573341 ctgcgccatt aaggttagca ggcctaacgt tttaagggtg actgttttcc ccccggtgtt 2573401 tggccctgtg atgacaatgg ttgaaaaatc gcggccaagc tcgatgtcat tggcaacaac 2573461 ctgatcaggc ggaagcaatg gatggcgggc ttttttcaaa cggataaagc cggtgtcgtt 2573521 cataatcggt tttgtcgctt taaccgcttt tgcatatcta gcttttgcaa aaataaagtc 2573581 aagcgtctgc agcacttgca aatctagaaa tagctcctct gtatactctg ccgttttctc 2573641 tgtcagcaca cgcaaaatcc gttcaatttc ttgcttttct ttcactttcg cctgctgaag 2573701 ggaattgttc atatctacaa tcgcctgcgg ttcaatgaat agtgtcgcac cagaggatga 2573761 ggtgtcgtgc acaattcctc catagctgga tctgtactcc tgtttgaccg ggatcacaaa 2573821 gcggtcattc cgaatcgtaa caatcgtatc agacagcatt ttcgatgcgg aagaggaacg 2573881 cagcatcgac tctaaccggt ctctgactct tgattcgagt gttctgagct gtgtgcggat 2573941 tcctcttaat gtttccgatg catgatcaag cacttctccg tgatcatcaa tgcaggaatt 2574001 aatgtcccgc tctaaatcgg acagcgtgat aagctgttca gcatgctgat ggatcagcgg 2574061 aatgtcgaca ccgtcttcag ccatttgcgt gataaaatgt ttcatttgtt taactgcata 2574121 aagcaggcct gagatttcag tgaattcaga aggactgaga acgctgccga tttccgcccg 2574181 tcttaacgct cctctgatat ctacaaggcc gccaaatggc gcttggcctc tcagccggat 2574241 aatgtcagaa gcttcgtcta cttcatccag ctgttttttg atttcgtcta tagaagcaga 2574301 aggcttaagc tcgagaagca tttcttttcc gagcgatgaa gcggcatgcc caataacctg 2574361 ttctttcact ttatgaaatt caagagctga taatactttt tgctgcacga ttgtgtgagc 2574421 ctccttactt aatcgttgcg cttcagaaat gcctctacgt ctttaagcga ccgggcattc 2574481 agaacgtttt tcgtttccgt ccatcctttg cgcgcggcag taacgccagt tttcatatcg 2574541 tctaacatct caatattatg ggcatcagta ttaatcacca atgtaacccc ttgttcgttt 2574601 gctttcatta aatgctctgt gcgcagatca aggcgcgcag ggttggcatt gagttcaagc 2574661 gccgtatttg ttttcctcgc aagctcaatc agctgatcaa tatcgatttc gtaaccggcc 2574721 cgtctgccga taaggcgccc ggtcgggtgt gcgataatgt caacatgctt gtttgtcagt 2574781 gccgtctcaa gccgtttcat aatcacgtgt tccggctgat taaaactgga atgaatcgat 2574841 gcaataacga tatccatttc cgcaagcaca tcgtcatcat aatcgagcgt accgtcaggc 2574901 aggatatcca tctcaacgcc tttcaaaata cggaagtttt caaactctgc attcagcgcg 2574961 tcaatttctt ttgcctgctg cttaagtctt tctgcagtaa gcccgttggc gacctttaaa 2575021 tattgtgagt gatcggtgat cgccatgtat tgatagcctt ttttgatgca ggcttcagcc 2575081 atctctctga tcgaaaatgc gccatcgctc cacgttgagt gcatgtggag atcacctttg 2575141 atttgcccga gctctatcag ttcaatgctg tcgctgtagg tttccacttc ctgtccgctt 2575201 tcacgaattt ccggcggaat cagcggcagg ccgaagtgcg cataaaattc acgttcactc 2575261 ggaaatgttt tgatctctcc ggtttcaact gtctcaacgc cgtattcact gatccgctcg 2575321 ccgcgttctt tggcgatttg gcgcatctta atattgtgat cctttgatcc cgtaaaatga 2575381 tggagtgttg tcggaaactg ctcttccgtc acaagacgga aatcgacgct tgtttcatat 2575441 tcaaaggaaa ggatgacgga caccttcgta tctccgcttg cgatcacgct tttgatgttt 2575501 ggcagctcaa gaagctgctc tcttacttca gccggatgat ctgtagcaat gatataatcc 2575561 agatccttca ccgtttcccg cgctctgcgg agacttccgg cacgagaaaa tttgatgata 2575621 tgcgtaaatt gagaaagatg ctcctcaatt tcccgcgcga tccggagggc gtagccgatc 2575681 gggaaccgtt caggctgttt tccggcttcc ccgagcgcct gtaatatttt ttcttccgat 2575741 tttttgccga agcccgcaag accctggacc ttttgctgct cacaggcttc cttcagagat 2575801 tctgcatcgt gtacgccgag ctctttatac agctttgcga tttttttgcc gccgagcccc 2575861 ggcagcttca ataaaggcac gagtccttcc ggcacttctt tctgaagcga ttcgagcgtg 2575921 cttgactttc cttcatctat atactcttta atgacgctgt acgttccttt tccaatgccg 2575981 gacagcgaca tcatatcgtc catttctgat aagcttcggt cgtcctgttc cagagctgcc 2576041 gccgcttttc ggaaggcgga tactttaaac gggttgtccc ctttgagttc catatagact 2576101 gcaatggttt caagcagccg gataatatct tttttatgca tatcataacc cccagacgtt 2576161 cacatatgtt tccatcatac ttgaaaaaaa cttctccgga caagagaagt ttttttatgc 2576221 cccgtactgt gtccacagct cttgtaaaag ccctgacaag tacggtgtat ggttaatgat 2576281 cacatttgcg agagacgatt gccccatcat ttgctgcaac gcgtctaccg gcagaacgga 2576341 tgcgacatac agcagcacaa atgtaaataa atagacttct agaaaaccga gaacggctcc 2576401 cagcatctgg ttgatttgtt taatcaccgg aatgccggct acaatactca ggaacgagcc 2576461 gatgattctc agtaagattt tagcaatgat aaataaaacg ataaacgcaa tcgcattata 2576521 gtacgctgct tccaaattcc ccgtaaaaaa agaaagagcc ggctgtcccg ctgaaaaatc 2576581 gggtgcggga atccaatgta aatgcggtgc cacgttttta tagaataaag ccgcaaaggc 2576641 aattgataaa ataaagctcg tcaagcggat aaactgcagg ataaaaccgc gttttaaccc 2576701 cagtaaagtc cccatcagga gcaagattaa gatgatgata tctagcatag ttgttcaatc 2576761 cttttcttta agctgacgct ccagtttttc acatttctct tgtaatttga cataatcgtg 2576821 caccacattt accgctgtca gcactgcaag tttatttata tcaaggtatg gatttttttc 2576881 attgatttct ctcattttat catcaacaat tccggcgaca tacctcatat gggctctgct 2576941 ttcttcaccg acaatcgtga agtgctggcc gtaaatgtca acggttgttt ttgttttttt 2577001 gccgtcagac aacgtttctc ctccattccg cgagaatcct agttcttatc ataacacgtt 2577061 tattaaatga atggaaagac gagcctcccg ctgttatgat acactggtat atacagcgaa 2577121 aagtgtaaaa aaaggagatt attacgtgtc ccattcagtg ataaaagtat cgttgtctgc 2577181 tattgaccaa atgaaaatga cgtacagcgg ttcacttaca gcctctgttc cgcagggagc 2577241 cgtttttcag gcaaaaccgc ccggctgtac cattacagca tatcaatcag gtaaggtctt 2577301 gtttcaagga aaaaacgctg cggcagaatc cgcgcgctgg ggaacagcag agcctcagga 2577361 aaagaagaaa acggccaaaa agccggctga tccccgctat gcccctccgg cagatatcgc 2577421 cggaatgtct gttatcggtt ctgacgaagt cggaaccgga gattactttg gcccaatgac 2577481 ggttgtatgc gcgtacgtcg acaaaaccat gcttccttta atgaaggaac tcggtgttaa 2577541 ggattctaaa gatttaaaag atccgcaaat catcgagatt gcccgaaacc tgattaaaac 2577601 cattccgtac agcctgctgg tgttaaagaa tgaaaagtat aacagcatgc aggaaaaagg 2577661 catgagccaa gggaaaatga aagctttgct gcacaatcag gcgatcacac atttattaag 2577721 aaaattggat ggagtaaagc ctgaagccat tttgattgac caattcgctg agccaggcgt 2577781 ctacttcaat catttaaagg gcagagacat tgtgaaggag cggacctatt ttagcacaaa 2577841 agctgaaggt attcacctgg ctgtcgccgc tgcttcaatc attgcaagat attcattttt 2577901 aatggaaatg gataaactat cacgcgcggc aggaatgacg cttccaaaag gggccggtcc 2577961 gcacgtcgat gaagcggccg ccaagctgat cctcaaaaaa ggggcatctg cactcagaac 2578021 ctttacaaaa ctccatttcg ccaatacgca aaaagcgcag cgccttgctg ataaaaaacg 2578081 ttcatagaaa aaagcttgca gatttctctg caagcttttt tatcagcctc ttaaaacagc 2578141 ttgatatgtg tcttctaacg ctttcagcac tttgctgtgc gcctttgtca cttcttcttc 2578201 agtcagtgtt tgttcaggat tgacatactg gagtgagaaa gcgactgact tcttgccttc 2578261 ctccatatgc tctccttcgt atacgtcaaa tacggttacc tctttcagaa gcttgccccc 2578321 ggcctcttta atgacgctct cgagctgtcc gcttgtgacg gttttatctg ttacaagagc 2578381 gatatcacgt gtcacagacg gatattttgg aatcgccgtg taaacaagcg gtgctgtttc 2578441 tgctgcgagc aacgcatgaa gatcgagctc aaatacgtat gtttccttta tatccagttc 2578501 tttttccaat gaaggatgga cttggccgat gaagccgatc agagaaccat tcaataaaat 2578561 gttcgctgtt ctgcccggat gcagctgttt gcgttcagac tgtacaaatt caatgctgtc 2578621 taggacgttg agtttgtcta acagcccttc cacaattcct ttgacaacaa agaaatcaac 2578681 tggtttcttt tcaccctgcc atagctgctt gcgccataat ccggtaacag ctcctgctac 2578741 gcgttctgtt tcaacaggtt ttgtgtcctc ttccttcgtt aggaaaacgg agccaacttc 2578801 gtacagtgca actgagtcag tctgcctcgc aagattgtaa gaaacagaat caagcagatt 2578861 tggaacaaga ctgtgtctga gaatgcttct ttcttcactc attggaagcg caagcacagt 2578921 attcagtgat ttttcaatcg caaacgctgt cgctttcttc tcgtttgtca gtgagtaagt 2578981 gatggcttgt gataagcctg cgccttcaag gaagcgtctg actttacggc gttttgcctg 2579041 atatggcgtt aatccgcctg tagttcccgc tgtctcagga agcgtagacg gaatgttatc 2579101 gtagccgtac agtcttgccg cttcttcgat taaatcctct tctattgtaa tgtcaccgcg 2579161 ccgtgatggg acagtcacaa cgagaagatc atccgcttca ccgaccgtaa aaccgagacg 2579221 tttataaatg ctgatcagtt cttctttact gatcgtcagg cctagaacgc tgctcacttt 2579281 gtcagcagat acgtgaatgt tatttgcttc gattgtcagg tgatcttcct caaccgttcc 2579341 agcaagcacc tcaccgccgg catacagatg gatcagctgc gcagcccgtt ctgctgcaag 2579401 acgtacgcgt gccggatcaa ttcctttttc aaatcttacg cttgattcac ttctcaaacc 2579461 aaggtctttg gaagccttgc gaaccttctg cccgttgaaa tacgcagcct caagcaaaat 2579521 ggttttcgta tcttcctgaa cctctgactc tgctcctccc atgacaccgg caacggcctg 2579581 cgctttcgtt ccgtttgtaa tgacaaggtg atcggcagac agcttacgtt cttgatcatc 2579641 aagtgttacg atcatttcat tctcagctgc ttttcttact acgacttcct tagagccaaa 2579701 tctgtcataa tcaaacgcat gaagcggctg tccgtattcc aacaggacaa aatttgtgat 2579761 gtcaacgacg ttgttgtgcg gacgaatgcc tgcattcatc agctttgtct gcatccaaag 2579821 cggtgacgga gcaatcgtga catttttaat gatttttgca gtgtacagcg ggttcgcttc 2579881 ttgatcttca attttgactg aaatgtaatc agacgcttgt tctgaagcag ccgggtaatc 2579941 cgtttgcgga agctttacct cagtgtctaa aatcgccgca acctcgtaag caacaccaag 2580001 catgttcatg gcatccgcgc ggtttggcgt taaacccagc tcaagaatcg catcgtcaag 2580061 ctgtaaagcc gctaaggcat cgcttcctgt ttcagcgtca ttcgggaata cgaaaatgcc 2580121 ttctgcatac tccttcgcca caagtttgct ttcgatacca agctcctgta aggaacagat 2580181 catgccgttt gattcttcac cgcgaagctt ggcttttttg attttgaaat tgcccggcag 2580241 caccgctccg actgttgcaa ctgcgacttt ttgtccctta tccacattcg gcgcgccgca 2580301 aatgatttgt acaggggctt cagctccgat atccacaagg cacttattca gcttatcagc 2580361 attcgggtgc tgctcgcgct ccagcacatg gccgatgaca acgcctttga tgccttctcc 2580421 tttgtattca attccttcaa cctcaatacc ggctcttgta attttttcag caagaacagc 2580481 cgggtccatg ccttttaaat caacataatc ctctaaccat ttataagaaa caaacatcct 2580541 tgcatcctcc tcttacgcct gtttaaactg cgaaataaat ctgacatcgt ttgtatagaa 2580601 gtggcggata tcatcaatgc catatttcag catcgcgatg cgctcaacac ccattccgaa 2580661 tgcgaagccc tgatattcct tcggatcaaa gccagccatt ttaagcacgt tcgggtgaac 2580721 cattccggca ccgaggattt caatccagcc tgttccttta catactgagc agccgttccc 2580781 accgcattta aagcatgtca catccacttc tactgaaggc tcagtaaacg ggaagaagct 2580841 tgggcggagt ctgatttcac ggtcttgccc gaacattttt ttcgcaacaa gttcaagcgt 2580901 tccttttaaa tcactcatgc tgatgttttt gtcaacgaca agcccttcaa tttgcataaa 2580961 ttggtgagag tgcgtcgcat catcgttatc acggcgatat actttacccg ggcaaatgat 2581021 tttaacggga cctttgcctt catgcttttc catcgtacgt gtttggacag gagaagtttg 2581081 cgttctcatc aaagtttcct ctgtgatgta aaagctgtcc tgcatatcgc gcgctgggtg 2581141 ttctttcgga agattgagcg attcgaagtt gtagtaatcc gtttcaacct ctggcccttc 2581201 ctcgactgtg tagcccatac cgataaataa atcttcaatt tcttcaatga caacagtgag 2581261 cggatggcgg ccgccgactg caacagggtt ccccggcagc gtgacgtcaa ttgtctgtcc 2581321 tgcaagcttc tgtttcattt cctcttcttc aagcttctcg tttttgtcag caatcgcatt 2581381 ggcaatacgc tcccttactt cgttcgcgag cgcccccatt tttggacgtt cctcagcaga 2581441 aagcttgccc attccgcgca gcacttctgt aatcggccct ttttttccga gatattgcac 2581501 ccgaatatca ttgacaacct tcaatgagct tgccgcttct acttgttcta aagcttcttg 2581561 ttccagctgt tttagctttt cttccatttt gcatcctcct tttatgtaaa caaaccgtca 2581621 tatgtctttg gaaaataaaa aaaacccgtc ccttgtacaa gggacgagtt gtggccgcgg 2581681 taccaccctt atttcagaca gactgatgct gtcgtcagct tcattgacat aacggaatca 2581741 gattccggtt cacctttacg cgcagtgtac gcggtcccgg cgacaactca agaggtgaag 2581801 ccaatttccg gctgcgttaa aaatgctctc agtcagcggc attttctccc tggaaagcag 2581861 ttgatcagaa attgaggtcc tctgtcacgg tttttgaaat attatgttct attatagaga 2581921 aatccaacgc ttggcgcaac actatcctcg caagtgatac acgaggatgg cagccgcaac 2581981 cgcaacgttt agtgattcag cctgtccgta aagcggcacg tacaggttca aatccgtttt 2582041 ttccagcaat gcagcatcta cccctgcacc ttcatttcct acaatgagcg caaaggattc 2582101 agactgagga atctcctggt aaggcgctcc gttttgcagc gccgtgccgt atacttttac 2582161 gccctctgcc ttcaattcgt ccacatatga aggcaggttt cttctcacaa caggaatatg 2582221 gaagtgagat ccttgagcag atcgcagtgt ttttccgtta aaggcgtccg ccgtgccgtc 2582281 accgagtaca accgcatcca aaccggccgc atcagccgtt cgaatcattg tgccaaggtt 2582341 tcccggatct tgaacagcgt caatcagcag caccttgcgt gccgttgcca gcttttcttc 2582401 aggcatatgg cacacagcgg caatctgctg cggcgtttcg gtttcagtca cagctgaaaa 2582461 cgcatcttca ctcagcatat agcactggat accagtctca agatctgaag gaatcctcgt 2582521 ttcatccttt acaaggattt ctttcacaat gcccgggctt ttcaacgcct cttcaacgag 2582581 gtgttctccc tctatcagaa atgtatttgt ttttgttcgt tctttttttg tgtgaagctt 2582641 tttccaatcc ttcacttttt ggttttttgc cgattctatt tgtttcactg tctatgtggc 2582701 gctccttttt ttaacatgat gttattatat cgcaagaaca gcacataata aaccaggtgc 2582761 agggttagaa tatacgtatt acattttaga aaaaggagcg ttttacatgg atcttaattt 2582821 acgtcatgcc gtcattgcca atgtcaccgg caataatcag gagcagcttg agcatacaat 2582881 cgtagatgcg attcaaagcg gtgaagaaaa aatgcttcca gggctcggcg ttttattcga 2582941 agtcatttgg cagcacgcat ccgaaagtga gaaaaacgaa atgctgaaaa cgcttgaagg 2583001 cggattaaaa cccgccgaat aagacatgaa accgggtgac agcgcccggt ttttttctta 2583061 tataataaaa acatgatgag ggggaacgcc atgtttttac agccgttatt agcgaaaaaa 2583121 attattgctg aagttaaaaa aatgtacgaa cgtgaagtca ttattgtaaa cacggacggt 2583181 cttattatgg caggcacaaa cgatgagcgt gtcggacaat ttcatgaggg agcgcttatc 2583241 tgcgcaaaag aaagacgcag cgtgattatt acaaaagaag atgaaacaag gttaaaagga 2583301 gtgaaagcag gcataaacct ccctgtattt tttgaccatg atgtgattgc cgtcttcggg 2583361 ctgacaggtg agcctgcaga gattcagcca ttcggagaac tgcttcgaaa aatgacagaa 2583421 ctgttcatta aggaatcgcg gcacttagag caatcccagt ggcgtgagag aatgctggag 2583481 tcctttatga tcgattggct gcaattaaag gagtggtctc ccagttttct tgagaaagct 2583541 cagcttcttg gtgttgacct ttcttcccgg cgccaaatga ttcttattca ggggtatgag 2583601 tggtcacctc atgatattga acaaatggca cgcagctgga aatcctcgta ccctgcggat 2583661 ttgttcatca ggtggggaaa tgaacggatt ttgattaatc atgaagtgcc gcagcatgaa 2583721 caaagggatc ggcttttgcg gaaaatcctt cacatttgtt cgtttgccaa taccgcaagc 2583781 agccaatata cagcagctgg cgccggaagg gctgtcgcaa gctccagcct gacagattca 2583841 tacgagcaag cggaaaaagc gctggctgtc agccttaagc gaaaaacgcc catatttgaa 2583901 gaggatctga agcttgatat gtgtctgacg gagatcagcc cgggaacccg aaacgaattt 2583961 ccgcaaagag tattaggaaa ggcgctagag catcaggaac ttatgaatac gatacggact 2584021 ttctttcatc acgatttgtc tttgaaacaa accgctgaag acatgcatat acacatcaat 2584081 acattgcgtt atcgtctggc taaggctgaa cagctgacgg gattacgttt tgaccgtacc 2584141 gaggacgtcg tcacgatgta cgtcgcactc tattttttag atcaagatac aaaatagaga 2584201 gagtttcagt ttcatttttt gtatgtttct ccatggaagg ctttgctttt tttcttttac 2584261 aatagattga aagcgttttt tgacaggggg atgggtgaaa tgatcaccaa ggatgtaaag 2584321 gagcagctga ttcaggtctc cggaccagaa aactttgatg actcgaatgc cggccgtctc 2584381 gtctattcat atgatgcgac gcctcagtat cagtctatgc ctgatgccgt gattgctccg 2584441 aggaatactg atgaaatatc acgcatttta acaatttgca gcgaacatcg agtgccgatc 2584501 gttccaagag gatcagggac aaacctgtgc ggcggcacgt gcccgactga aggcggactt 2584561 gtgcttctct ttaagcacat gaaccagatt cttgaaattg atgaagaaaa tttaactgcc 2584621 acagttcagc cgggcgtcat tacgttggat atgatccggg cagttgaaag caaaggttta 2584681 ttttatccgc ctgacccgag ttctatgaaa atatcaacta tcgggggcaa catcaatgaa 2584741 aattccggcg ggctacgcgg attaaaatac ggtgtcaccc gcgactatgt tattggactg 2584801 gaggttgttc tcgcaaatgg tgacatcatc cgcaccggcg gaaaactcgc aaaggatgtg 2584861 gccggatacg atctcacacg tctttttgtc ggctcagaag gaacactcgg cattgtgaca 2584921 gaggcaatcg tcaaactcgt tccaaagccg gaaacaaaga agacgctgct tgccctttat 2584981 gaaaacatcg atgccgctgc tcaaacggta tcggacatta ttgccgcaaa aattataccc 2585041 gctacgcttg aatttctcga tcagcctaca ctattggtga ttgaggatta tgccaaaatc 2585101 ggacttccga caagcgcaaa agcagttctg ttaattgaac aagacgggcc atttgaaact 2585161 gttgaacggg atatggaaaa gattgaggcg atctgcaaaa aaggcgacgc cgtatccgtt 2585221 cagaccgcac aaacagagga ggaagcgttt gccctgactg aagcccggcg ttctgcactt 2585281 tctgccctag cccgcctcaa accgacgacg attttagagg atgcgaccgt tcctcgctca 2585341 gaaatcgcca atatggttaa agcgattaat gatattgctg ctaaatatga tatttccatc 2585401 tgcacctttg gtcatgcggg agacgggaac cttcacccga catgcacgac agacataaga 2585461 aataaggatg aaatggaacg tgtcgaacag gcttttgccg agatttttga gaaagcgatt 2585521 gaacttggcg ggacgataac cggagagcac ggagtcgggg aaatgaaagc gccttacttg 2585581 gaaatgaagc tgaaaaaaga aggcattgat gcgatgaaag cgttgaaagc ggcatttgac 2585641 ccccggaaca tattaaatcc cggcaaaatg tttgcgaaag atgccagaaa acgtgtggtg 2585701 gcggaaagat gacaacagaa aaagaaatga aacagatcca aaatgaattt aaagagcgta 2585761 tggatgaagg agagttatta aattgtatgc gctgcggctt ctgtcttcct tcctgtccga 2585821 cctatatcga atcgggattt caggaaacac actctccgcg tgggcgcatc gccttaatga 2585881 aagccgtagc cgacggtatg attgaaccgg atgaagatgt cgaacggtcg ctgtcacttt 2585941 gcctcggctg ccgcgcctgt gagcctgtat gcccgtctgg cgtgaaatac gggcagctgc 2586001 ttgaggaagc cagagatatt atccaccaaa ataaaaaaca ctctcttggt gaacgtgtca 2586061 tgcgaaagac ggcttttcac gagctgtttc cgcatcaaaa ccgcatgcgc tcagctgtaa 2586121 gccttatcgg tttgtatcag cgttcaggac tgcaaaccgc tgtgcgaaaa tcaggcatgc 2586181 ttcgggtcct gcctgagcat ttgcggacga tggaagctgt tcttcctgat gttccaaaaa 2586241 gcaaagacat gaaacatcgg ccgcgtttcc tgccttccat tggccccatg aaaaaacggg 2586301 tcgccttttt ttcgggctgc ttaatggata caatgttttt accgaccaat aacgccacat 2586361 tgaagctttt acagctggca ggctgcgaca ttgtcattcc gcctgaacag gcttgctgcg 2586421 gggcgcttca tggacacagc ggtgaaaaaa acacagggaa agagctcgcg aaacaaaata 2586481 tcgctgcttt cgaagcatta gacgtggatg cagtcattac aaacgcagga ggatgcggag 2586541 cctttctcac tgaatatgat catttgctga aggatgaccc tgagtggtcg gaacgggctg 2586601 ccgcttttgt tcaaaagctg aaggattttt cttctgtttt ggttgaactc gatttccatc 2586661 aaatggatct agcactcgag acgcctcagg tcgttaccta ccaagattca tgtcatctaa 2586721 gaaatgtgat gcatacgtca cttgagcccc gccagcttct taaaagcatc aaaggggcgg 2586781 aattcaaaga aatggagaaa gcagacagct gctgcgggtc agcgggaatt tacaacatcg 2586841 tcgaagttga aatgtctatg aaaatactgg acagcaaaat ggctgccgtc aaagcaaccg 2586901 aagcgatcct cattgtaaca gcaaatcctg gctgcctgct gcagatgaag ctcggcattg 2586961 aacgcgaagg actaagcggt aaagtcagag ccgttcacct ggctgatttg ctattagaag 2587021 cagccgggca caaaacatca tgagaaagcc caaaacagac attgttttgg gcttttgtgc 2587081 gttattccat cggactgcaa atttcgatat aatgtccatc cggatcagcg atataggcga 2587141 ccgtctgccc ccatggtttc actttcggct ccccgataat cgatacgcct tgttctctca 2587201 tccttttgat gaccgcttct acattttcag taacaaaccc gatttcaaat gtgtttgaag 2587261 cagatgtatc cggaatgtcc agcgccgtga tgtctctggc gctttcccgg gtattaagcg 2587321 ccaatatcgt agaccctgta tcaaattcga catacgtgcc gtgttcagca cgaatcggca 2587381 gtcctaaaat atcccggtaa aaaatgaata gcccgcttgc tgtccgatac gtatagaata 2587441 agatatttca ttgatagatt cattgccaac ccctctcagc attttcaata gtccttctag 2587501 cccggtatag atgcttccat ccttaagctc ggatctttcc acatctgcgc ccattttttc 2587561 acagccgcca cgataatgat gaagcctaac accagcatga tgatagataa tacgccattc 2587621 aatacactat atcctgctgc ttcaggattg agatacacat tgcgcaccat ccaatagccc 2587681 gcataattga cagtgacata taaataggca agcgggataa ggcaagtcag aatgtaccgg 2587741 cgtttatcgg cgattttcag cacgatcgtc gctccgataa tcagccccac tgaagccatc 2587801 agctgattag aaacgccgaa gagcgcccaa atggaaccga tatctcctga atacagcaag 2587861 tacccccaca tcaaacaggc aagcgcgctg gcaaatacag agcccggaat ccagtctgtt 2587921 ttcttcagcg gcttatacac ctccccgaag aagtcctgga tcaaataacg ggcgacacgt 2587981 gtgccggcgt caatcgctgt taaaataaag accgcttcaa acataatgac aaattggaaa 2588041 aagtatgagg ccaaatggct gaaaaacggc attccggtaa aaatataagt catccctacc 2588101 gcaagcgtga cggctccccc tgttcttcct tctaagtcca aaccgatttc cccgctcaat 2588161 tcaggcaaat gtacgacatt catgccaagc gtacggaaaa cctcaggcgt gctgttaatc 2588221 gcaaagtaat cagcaggctg taaagcggtc gctgcaatca gcgccatgat accgacaaga 2588281 cactcaacaa gcattgcgcc aaacgcaacc ggcttcatat cactccattt attcagcatt 2588341 ttcggtgtcg ttcctgagcc gacaaaggca tggaacccag agatcgcccc gcaggcgatg 2588401 gttattgaga tgaacggcca gacaggtcct gccagcaccg gccctccgcc ttttacgaat 2588461 tctgtaaacg cagggaacgg aatggacgga ttgacgacaa acacaccaac aatcaaagcg 2588521 ataaaaacac cgattttcat aaagctgctt aaataatcac gcggagccag aagcagccaa 2588581 acgggaagcg cagccgcaaa aaacgcataa acaggaagcg cgattgcaag cgttttcgta 2588641 tctagcgtta aaaagtcacc gagcgcggta gtctgtaccc atggaccgat aaagactcct 2588701 gccattaaaa agagaaagcc gaccgttgaa gcgagcttta aatttcccgt tttcttataa 2588761 aataagccca cacccatcgc aatcggaatc gtaatcccca ccgcaaatgt tccccatgga 2588821 ttacgttcaa gcgcatgcaa gacaaccatc gacaggcccg ccattgtgat cgtgatgata 2588881 aacagcatgg acagtcctgt acaaaatcct gcaacagggc caagctcatc cttcgccact 2588941 tccgacagcg attttccgtt tttgcgcatc gatgcaaaca acaccacaat atcatggacg 2589001 gctcccccaa ttaccgcccc gattaacagc cacaataatc ccggcaaata gccaaactgc 2589061 gccgccagaa ttggtccgac cagcggcccg gccgctgcga tcgcggcaaa gtggtggccg 2589121 aacgaaaccc atttatttgt aggcacatag tctttcccat cctcaagcgc atgagcaggt 2589181 gttggcttgt catcattcac tttgagaacc ttcaccatca taaatgttcc gtataaacga 2589241 taggcaatag ccaaaataca cattgatgct atcacaattg taaccgcatt cattttctcc 2589301 catccccttt tctgtttttc ataaatatat cataatttca tggtgaaaag cggtcatttt 2589361 ttcctataca aaaagccggc tggaatgggc cggctcgtgg cagttgaaag acaagccgga 2589421 gagaaatctc cggctttgct attcttatga ctgttttttc aggcggatca cattccagga 2589481 aagcggcgtg aaatgagcag ttaagccgtt ttcgctgaca gacgatgatc cgttggaatg 2589541 cggaacgaca ttttttctgt tatgctggtt tgttgctttg atatcctgat gctcaagtac 2589601 gatgtgctct gcgatttggt aggattcaaa gcctctgagc gaaatctccg tctccatctg 2589661 atcctcagcc ttgtttaccg caaaaatagt gagtgtttct tcctcttcag agtacacaac 2589721 agcagcatca acatatggca catcagtgaa atcagaacaa tcgtacttag gagaagaaat 2589781 aagcggtttc agtgactcgc cccttccgta aacagaagca tgcatgtatg gatagaaaat 2589841 cggctgtctc catgcttctc cgcctttttc cgtcatgatc ggcgcgatga cattaacaag 2589901 ctgtgcaaga cacgcaattt tcacacggtc tgcgtgctgc agcatcgtaa tgagcagaga 2589961 gccgactaat aaggcatctt caaaattgta aatatcctct aaaatcggac gcgcagtgat 2590021 ccacggctcg acttttttat cagcctcatt tgagtggtac cagacgttcc attcatccag 2590081 agagagattg atagttttct tgctgcgtgt ttttgctttt acatagtcac aggtcgcagc 2590141 gactgatttg ataaaatgat ccaaatccat agaacgtgcc aagtagtttg gcagattgtt 2590201 atcccggttt ccgtagtaag tgtgaagaga gatatagtcg acatgctcat acgtatgctc 2590261 aagcaccttc gcttcccaat cgataaaggt cggcataccg ctgtttgagc tgccgcaggc 2590321 aacgagttca attgatgggt caacccactt catgaccttt gctgtctctg cggcaagccg 2590381 tccgtattca tcagctgttt tgtggccgat ctgccatggt ccatccattt cgtttcctaa 2590441 gcaccatgtt ttgatgccat acggctgttc atagccatgc gatcttctta aatcactcca 2590501 gtaagagcct ttcggatggt tgcaatattc aacgagatta cgggcggcat ctatgcctct 2590561 tgtgccaagg ttgacggcca tattgacctc agtgttcacc ttttttgccc aagataaaaa 2590621 ttcatttgtt cccacttcat tggtttctgt cgtttgccat gccaagtcaa gccgtctcgg 2590681 gcggttttcg actggtccga caccgtcctc ccagttgtat ccggataaaa agtttccgcc 2590741 cggatagcgg atgatgggaa cctgtaattc tttgatcagc gactggacat cttttctaaa 2590801 tccatcttca tccgcttcag ggtgatcagg ctcgtatatg ccttcatata ccgcacgacc 2590861 catatgttcg ataaacgagc cataaatccg tttatctact tcaccgattt tatattcttt 2590921 gtctacaatc attcgcgctt ttttcatcac acgtttcctc cttcattaac ctttgactcc 2590981 ccctaccgtc aggccggaga taaagtactt ttggaaaaac aagaaaatga taatcaccgg 2591041 caaaatcgca aatactgagc cggatataag catgtcgtaa ttatttccat aagggctcag 2591101 caagctggac agccctattg gaagcgtaaa catttctttc gaccgaagca caatcagcgg 2591161 ccacaagaag ttgttccagc tgtttaagga ctgaaggata atcatcgcac cgaaagccgg 2591221 tttcatcagc ggtgccataa tcctgaaaaa gatgccgaat tccgtacagc cgtccatcct 2591281 tgcagagtcc agcagatctc ttggaaggcc aagagcatat tgcctgaaaa agaaaacagc 2591341 aacaggtgaa acgataaacg gcaatatgac acccgtatat gaatcgatca agtgcagtcc 2591401 gacagtaagt ttaaacagag gaagcatcat cacttccagc ggaaccatca taataatcag 2591461 cacaagaaca aagatgatat ttctgccctt aaaatcataa accgcaagcc cgtacccgat 2591521 catcgaagaa aaaaacagag tgagcacagt cgtaaaaagt ccgagtacaa gactgttaaa 2591581 aaaccatttg aaataaatgc tgccgccatt aaacagaaat gtgtagttat caaaactcat 2591641 cacttttgga tcaatatcaa gattcagccc cacacgcaaa agctcagatg acggctttaa 2591701 tgatcctaaa agcaaacaga aaatcggaaa aagatacaat aggctcagca tcataaaaaa 2591761 cagggtcagc gcaattctat aaacgctaaa ctgaggactg tgccgcaaca tttatccctc 2591821 ccccttaaac gagcctgaca gctttaatga aatcaggctg acaacaagga tcacaatcaa 2591881 aagcacaatg ccgatggccg ctccgtatcc catttcattg taggcaagtc cctgctgata 2591941 caaatatccg acaagcgtca gaccaatatt acccggggaa ttattctgcc aaaggacgta 2592001 gctttcctca aacatcctga agccgccgat gatgctgatg gtcagcacat atacggttac 2592061 aggcttgaga aacggcagcg tgatgtgcag aaattttttc attgtattcg cgccgtctat 2592121 atcagcggct tcgtacagct ctttcggcac attttgcaaa cctgctaaaa agtaaaggat 2592181 gttgattccc atccatctcc atgaagcaag cagcaccatc aaaaacatgc cggtatgttc 2592241 attgttcatc cagttctgag gtgaaaagcc gagtttaagt aggatggaat tggccagaga 2592301 cgtttccatt tctccgaaga tcagccgaaa aatgatcccc gcgacaatgg ttgaggtcaa 2592361 tgccgggata aataatgctg atttaaatat atttctaaat ttgaccagct ttgaattcag 2592421 gaatatggcc agaagcaatg gaacaggaat cagcacgatc agcgtccaaa aggtgtattc 2592481 cagcgtattc caaagggcgg tatagaacgt cgggttgttt agcgctgtat aattagacaa 2592541 tccgacaaag gacacctctc ccggcaaaat tctttggaag ctcatgatga agacactaat 2592601 gatggggtat agaaaaaata cgagaaagga taaaacgaat ggcgctgtaa acagataggg 2592661 cgccgctttt tttgaataaa acagatctcg ccagcctgat tgtttcgcag ctgaaggaac 2592721 gggatgaacc gttcccgttt tcacaggttt catgagaacc tccccgcttt cactttttga 2592781 atgggattct atttctgttt cagttcacct gccgctctgt ccaaggcttg tttaggcgtt 2592841 ttttgctgag atttaagcgc gtcgaacaat acgcttctgt tgacaaggtc tgaagccttg 2592901 gcaaaatcct catgtaaata aattggattg atttcatcct tgatatcgag cagcacagaa 2592961 aaaatgcctg ttccgttttg gaagtaatcc gtgtatttgt ttttctcttt caattccttg 2593021 gagctccaaa catcccagcg aagcgggtca aagccgagta cgctccagag ttttttattt 2593081 ccttcttcag agcccttcgc aaaggccaaa aactcttttg ctaactcaac atgcttggat 2593141 tgcttcggta caacagttgc cgtaccgccc aaacctgccg agcggtcgcc cccctctttc 2593201 catgccggga gcggtctgat ggcaatcttc cctttcagat caggcatata atcgataaat 2593261 cttcccatat accaaatcgg catgagaact gaagcagctc ctccttggtt cataaagccg 2593321 tagtattctt cactgtgatg cccgccgccc ggcgcaggaa tcatcgtttt atcattgatc 2593381 atgtctttta aatattgaag tgtttttacg ttggtgtcat tattgaggat cagcttgccg 2593441 tttttatcaa aatagcctga gttttgctgt gaaatcatag ataagaacgt tgcggaatca 2593501 tttgtttcca ccgttcccat cggcttcccg gtcactttgc gcactttctg tccggcttta 2593561 tggtaatcat cccatgtttt aatatcgtca ggattgacgc cggctttttt catcacatcc 2593621 atgttataaa acatgaccgt tgtccctaca tgtgtatcga gtccgtaaag ctttccgttt 2593681 ttgctgtaca atgtcagccg cgcctcaacg aatttatcgc gatccttttc aatcagcgga 2593741 gtcaagtcgg caagcggtat gtcagagccc ttcaaaaagt ttgaaaaacg ggccaattcg 2593801 acatctgcaa tatcaggaac gccttctccc gctattaggg agatagataa gttatcgtgc 2593861 atttgtccat atggataaac gaccgtattc agcttaattt tgcggtcagg atattttttg 2593921 ttccattcct tcaccatttc cacatagaac tgctcatgaa gcccgttaaa tgtccaaaag 2593981 gtcagctcag tttcacccga tttgccggat gatttttctg ctgaacaccc ggcaatgact 2594041 aatgtcagca acatcatgag cacaagaaaa cagacagtca tttttttcat ctgcgttacc 2594101 ccttccattc gaggtgcggg ctattcatat agaccatggt tgatcagcgt tttgttttca 2594161 ttgatgattc ttaatccggt gcatcggtct cttaaggtgt gcgcgtgtct gaaggcattt 2594221 ttgacggaat cctgcccgac accgatttcg tcaaaatacg cagggcctcc ggctgatctc 2594281 agccaatcag ccagcacttc tcctctcggg agtgtttgat aagccgattg gatggcttcc 2594341 cggcggcttg gtgaaaattc gttcagcccg tcatcctgag cgagctttct gtatgtgtca 2594401 gttaataaaa cagcggcaca gcccaccttt gccccatgaa gaatctgagg ccgttttttc 2594461 tccattaact ccatttcaat ccaatgtgaa atatgatgct cgccgcctga tgccggtcgg 2594521 gaatgatcta atgccagcat gacaagcccc gatacaagta aagactccat caaaacccgt 2594581 atgccagttt ccgttttcat cgcaatgtct tctgtgtgtt caatgcaggc agcaagcgcc 2594641 tcctgaacga tcttagctcc tgcaggcgaa taaggctcac cggcaagatg ccgggatatt 2594701 tcccaatctg ctaaagacgt gattttaccg agcatgtcac caaagccagc cgccaccatt 2594761 gactgcggtg ccgcttttaa tagatccaga tcagcgaaca gcgcagatgg ggccttcgtt 2594821 tgaatggttg ttttcgtgcc gtataaaata atcggcgcac cggctgatgt aaaaccgtct 2594881 acagatggag cagtcggata agaaataaac ggcaaatctc tttgaaacgc cgcaaagcgg 2594941 acgatatcat gaatcgtgcc cgaaccgact gcgatcatga catccgttgg ttgtttcgta 2595001 tggatcagca catgaatgag cgatcgttca tcagctgtca catctccggc ttcattttct 2595061 ggaatgatca ggcactcggc ctgaaatcct tcttgattca gtcggttttc taaatcaatt 2595121 cctgcaatgc ggtgtgtatt cgcgtcgcag acaaggacaa tatgttgatt gttttttcgt 2595181 tttacataat ccaaaagcga atcagctgct tgcttaccga gaacaatttc ttcaactttt 2595241 ataggcaacg tcttttctcc ggcgttttca aaagcacgct gaacgtcagc tgcgatacga 2595301 ttcatatcag aatcccctcc tcagccaatt tggttacatc cttaatagaa tccagcacat 2595361 aatccggcgt gtacaaacgc tgttcaccct gtttcgcaga accagttagc actaaggcgc 2595421 ttttcatgcc ataaagcttc cccatcgcaa tgtcagattc aatgctgtct cctataatca 2595481 tgcattcatg tgcggacagc cccattgctg tacaggcagc ctccgccatc agccatgacg 2595541 gttttccgac aacaagttca gtcttcgctt gtgcagaagt ctcaattgcc ccgatcattc 2595601 cggccacatc aatggcattt ccgtcttcgt tcggaaaaga gcggtctttg tttgtagcga 2595661 taatacgagc gccgccggca gccgcttgaa aggcttgatt taaatcgtcg tacgtgagcg 2595721 tttcatgaag ggagatcacg agccaatccg cttccttcgg ttcgctcgcg ttctgcacac 2595781 cggccagcct cagctcgtca accaagcctt gctccccaag cacccatacc tttgaaaaac 2595841 gataatgttt tttcagaaaa gccgctgtca cgcttgatga cagaacaatg tcgtttacgt 2595901 ccgtttcaat ccccgcgcca agaagttttt ttctgcacat ggcacgggag atattccccc 2595961 ggttgcttaa aaagacgatt ttctttccca ttctcctaag cgttttgatc gcttctcttg 2596021 ctccttcgat caactcattt cctctgaata cagtaccgtc caagtcaatc agaatgccag 2596081 ccggtgacac aggcgtatca tgactggcca taatacgcat ttgctccgtg ttttcgataa 2596141 aaatgctttt catgcaggac tgtattgatt ggggttacat ccttgttcag cataatggag 2596201 tgataggcca tttcggcaac cgtttctaat acaactgcgt tatgaatggc atttaaggcg 2596261 tcagtgcccc agcagaacgg tccgtgatta ttcacgagca cacccggcac ctgttcgtaa 2596321 ttatgatgct gaaaggtttc cgctatgact tttcctgtat tcagttcgta gtcatgaatg 2596381 atttcttcat cgtacatttc tcgagtacat ggaatcgcac tgtcaaaata atcagcatgg 2596441 gtcgtgccta acggagggat gtctctgccc gattgcgccc agcttgtcgc ccattgagaa 2596501 tgggtatgga caattccccc gatattcgga aaggctttat atagataaac atgggtaggt 2596561 gtatctgaag aaggtttaag cgagccttcg acgacctctc catcaaggtt caaaacaacc 2596621 aagtcatcgg ctgtcaggtc gctgtattcg actccgctag gtttgatgac aattctttct 2596681 ttttcacggt caatgccgct gacatttccc cacgtaaagg ttaccagctg atgctcttga 2596741 agcttcaggt tggcagccag cacttctttt tttaatgttt caagcatgct ccatcaccct 2596801 ttatcaattc tttttggcgg cagatgaaaa ttgaagattt ttgatcgttt tcagacgctt 2596861 catgacatgg ttttcttttc cgaaataatg aaccagctct ttatattcag cgtacaattt 2596921 ttcataaacc gcggcgtttt cggcatttgg cgtataagtt atatctttca gttttcccat 2596981 gttcgccgct gcctttttga tatcatcgta gccgcctttt tctttgcctg ctgcaagcgc 2597041 gccgaaaatg gcagatccta aggctggggc ttgcggtgaa ccagagattt taatgtccat 2597101 gtttgtcaca tccgcataaa tctgcatgac aaacgggttt ttctcagcta ttccgccggc 2597161 tgcgaacagt tcctcaatcg gaacaccgct ttctttgaat gtttcgataa tcatccgggt 2597221 tccgtaagct gtcgcttcaa ctaacgctct ataaatctct tcaggcttcg tcagcagtgt 2597281 catgccaagc agcatccctg ttaaatctgc atcaacaaga gttgaacggt ttccattcca 2597341 ccaatctaaa gcaagcaagc cgctttcacc aggcgcttga tggtttgctt tctcactcag 2597401 cagctcatga acgccaatgt ttttttcctt tgcttcctct tgataagctg gcgggacaca 2597461 tgttttcaca aaccagtcaa aatgatcgcc gacacaggac tgcccggctt catatcccgc 2597521 atagcccggg agaattccgt tgtccacaac gccgcacatt cctggaacga tatgcacctc 2597581 ttcaccaagt agaacatggc acgtcgaggt tcccataatc atcagcattt tccctggctc 2597641 tgtaatgccg accgccggta ccgaaacatg agcgtccaca ttggcaaccg caacagccgt 2597701 tcccgggaga agccctgtca gctttgccat tttttcagtc agactgccgg ctttttctcc 2597761 tactgaatga atagaacctg acaatttgtc ctttgtaatc gttttcattg aaggatttaa 2597821 tttctcaaag aaatcatctg acggataccc cgctttttca ctccacatcg ctttataccc 2597881 tgcggtacaa ttgcttcgct tgagcgagcc gcacagctgg tacacgatcc agtccgcagc 2597941 ctcgatgatc cggtcagccg cttcataaat gtgaggcgct tcctcggcaa tttgcatgac 2598001 ctttggaatc atccattctg atgaaatttt tcctccgtac cgctgtaaaa aagcctctcc 2598061 ttcttcttcc gcgatttgat tgagccgatc agcatgtttt tgggccgcat gatgcttcca 2598121 gagcttcaca tagctgtgcg gctcctcttc atattcaggc agcatgcata acggctgccc 2598181 gctgctgtca ataggaagga tcgtacatgc cgtgaaatca attccaatcc cgataatgtc 2598241 tttcgggtca acgcccgtct gttcgagtaa agacggaatg gttgtttcca agacttcgag 2598301 gtaatcagca gggtgctgca gcgcccagtc acgcggcagc ttttgacccg tttttggaag 2598361 gacggtatca atgacagcat gcctgtattc ttttacagca gccgcaagtt cctcccctgt 2598421 ttggacatga acgagcactg ctcttcctga taaagttcca aaatcaaccc ctattgtgta 2598481 agccatgtga catccccctc tacttttgaa gccggtaaag cgcctcgttc cattttaact 2598541 cgtgtttcag tttatgaatt gtcgtatcac gggaaatgag aacactttcg attcccgcca 2598601 tttccgccca atcaagcatt tgctccgctg tcagttcata agacaggcag gtatggtgtg 2598661 caccgccggc taaaatccat gcctccgctg ctgttttcaa tgacggctcc ggcttccaga 2598721 gaacacgggc aaccggtaaa ttcggcatgt ctttttcaat ttcctggccg ttgacttcat 2598781 tcagcacaag gcggaaacgc ccgccaatat caacaatgct agcttgaatg gcagaaccgc 2598841 tgatgccgtt aaataccaaa cgcgcagggt cctctttgcc gccaatcgaa agcgaatgaa 2598901 cctcgatttt cggctgatcc aaagcgacag tcggacacac ttcaagcatg tgagagccca 2598961 gaatcatttc atttcccggt tcaaaatggt acgtgtaatc ttccatgaag gaagttcttt 2599021 ttcctttagc catgattttc atcatccgta caagggccgc tgtcttccaa tctccttcac 2599081 cggcaaaccc atagcctttc tccatcaggc gctgaacggc aagtcccggc agctgtttca 2599141 ttccgtgcag cacttcaaac gatgtcgtaa acgctgtgta tccgccttgc tcaagaaaag 2599201 cggttaatcc aagttcaatt ttcgcctgtt ctttaatgga cgctaccttt gcttcgtcac 2599261 gttttgtttc ctcactgatc acatatagtc tgtcatactc ggcataaagc gtgtcaacct 2599321 cgtcgtccgt aatgcgatcc atcacttcaa cgagatcccc gatgccatat ccgtcaacct 2599381 gccagccaaa ttgaatatgc gctcccacct tgtctccgtc cgttaccgcg acatgacgca 2599441 tgttatctcc aaatctggca accttaatat gtctgctttc atttaatgca gccgccgtat 2599501 ccatccactg ggacatttct tttttcactt cttcatcatc ccaatagccg gcaatgactt 2599561 ttcggctaag ccccattctc gagttgatgt aaccgtactc tcgatcgcca tgcgcggatt 2599621 ggttgctgtt cataaaatcc atgtcaatcg taccccacgg gatatcgcga ttatattggg 2599681 tatgcaaatg cataagcggt ttttgataag aggaaaggcc ttctatccac atttttgcag 2599741 gggaaaatgt gtgcatccat gtaatgatgc cagcacatgt ctcactgtac tccgcttctc 2599801 ttaacagctc tctaatggtt tccggtgaag tgacgacggg cttatgagtg attttatatc 2599861 tggaagaaat cccgctgagc ccctcacaaa tgcttttagc atgctgatct acgagttcca 2599921 gcgtctcttc cccgtatagg tgctggcttc ctgtcacaaa ccagaattca taatcctttg 2599981 tctgaagcat gtaaactgcc cctttctcat aaaataaaac gctttcaaat acaaaagata 2600041 cgtactaatg atagaaaata aacctataaa taaatatttg tacgaacaat tttattatag 2600101 taattgacta ttatactgtc aatcttttct tttaaaaaaa gccgggggca gagcccggct 2600161 ttttaattca ataggacggc cagcccgagc tccaattcaa atcattgatg agaagctttg 2600221 gaatgccgtt gtcattggca tcataggcat ggcgaacaag aatgtttccg ttcacaatat 2600281 cctggcctcc aggtcctttc cattggtcat tgcccgaatc caaaatggtg cctccgcctt 2600341 caagcatgct ttttccgctt ttatcaagat aagggcctgt aatgcttttg gatcttccgt 2600401 aagcaatttt gtacgtactg tttaccccgt cacagcattt atcaaatgaa accattaaat 2600461 agtaatatcc attttgatac gtaagagtag gagcttctaa ggcacctcca ttattcggtc 2600521 tagctgcaat cgaatagagc gagcctgtag gcttcattgt actcttatcg agcttagtca 2600581 gcttaatgcc gctccaaaac gagccgaatg caagccacgg gttgccatcc ttatcgaatg 2600641 tcagctccgg atcaatggcg ttataattat ttgagcttgt cgaacggatc accaagccct 2600701 cgtccttcca gccccccgaa ctgatgcttg ttgaagatgc caggccaatg gcagatgtat 2600761 tgcttccaaa agaagaaacg gaataatata gccagtactt gccgttatag tattggatgt 2600821 ccggcgccca ctggttttgg ccataattcg gcacataatt ggaccaccac gatagcggtg 2600881 tagtgaaaat ggatttttgt acggtccaat ttttagcgtc tgaagacttc aaaacccgca 2600941 gtccccgttc ttcagtaagc cctgttccga gcgcatacca tgagctcccc tctttaatca 2601001 tagtcgggtc atgaagcagc tcattggatg caccccaaaa cgctgcctct gcgggagcag 2601061 cagaagtgaa tatcaaacct gcagccagag ctgcactcga aaagtgtaag aagcgtttcc 2601121 atgttttttt ctttttcaat tttgttcaac ctcctttatt ttagaaagcg cttacaaatt 2601181 agattattta tcctcccttc ctgtcaaatc gactgcgtat cgtatatcgt catgttcagg 2601241 aaattttcgg tatccccttt attgtagtca ctatgctgta atttgtacag acaaaaaaat 2601301 agaatccacc tcaataggcg gattcttccg tatctttatt ggtacgtaat ttcgtcaacc 2601361 gtttttcggt ctaacttctt aatgacttct gtaattaact ttaccgcgtt ttcataatca 2601421 tcacgatgca gcatggccgc gtgcgtatga atgtagcggg ttgcaatggt aatggacagc 2601481 gcaggaacgc catttgccgt caaatggatg gcacccgaat cagttccgcc gccggcaatg 2601541 gcatcaaatt ggtacggaat gccggcttcc tccgcagtgg ctacaactgc atcgcgcaaa 2601601 cctttgtgag agaccatgga tgcatcgtaa acgataatct gcgggccttt gcccattttg 2601661 ctctgcgctt ccttctcgga aatgccaggc gtgtctcctg ctatccctac atcaacacca 2601721 aacgcaatat caggctgaat ggtgtgtgca gccgttttcg ctcccctcag cccgacttcc 2601781 tcctgcacgg ttccgacgcc atacactata tttggatgat ctgtgttttg taagtttctt 2601841 aacacatcaa tagcaatcgc acagccgatg cggttgtccc aggcctttgc gagtaggaat 2601901 ttttcattgt tcatgaccgt aaattcaaaa tgcggaacga tcatatctcc cggaagtaca 2601961 ccccactcca aggcttcttc ccggcttgaa gctccaatat caataaacat gtcttttatt 2602021 tccactgatt tttttcttgc ttcaggagac aaaatatgag gcggcttaga tccgataacc 2602081 cctgtgattt ctcctttttt tgtgacaatg gtgacgcgct gagcaagcat aacctgagcc 2602141 caccagccgc caacggtttg aaaacggata aagcctttat ctgtgatttg tgtcaccata 2602201 aagccgactt catccaaatg tccggcgatc ataattttcg ggccgttttc tgcaccagtt 2602261 ttttttgcaa ttaaactgcc caggcgatct gttgtcacct catcagcaaa tggttctatg 2602321 tatgatttca tcacttgcct tacttctctt tcattgcccg gtatgccttt tgcatctgtt 2602381 aaatctttca gcatggtcaa tgtttcatct aattttgcca tgttccaaac cctccttcat 2602441 cagtcctgca ttcttattat acaaaacatg gcgctaacca tacgactatt tcacttgaaa 2602501 atcgggtata tgtttttaca gctttctttt agaaaaagtg aaaccttttt ctatgctttt 2602561 cgtattacat cagatcatca ccataaggga ggtgccttca cacaatgttt gtcatggttc 2602621 taaggattat tttgcttgca ctttttgctt attgtattta tgccgtggtc aaatatgtcg 2602681 cgaatcctaa gagaaggctt aagctggccc aatcaaaaga acatttttat attattgatg 2602741 aacaaaacaa tacccggaag aattttcagc tgacgtataa aggcgtgctt tttgagggag 2602801 aaaagcatat tccttccaag gatcatccgc tgtttattca cacgatcttt gtctggacag 2602861 aatctcctga gaagctgaaa catttctctg caaaagattt tgagaacatt gaagaaaaag 2602921 tgctggaacg atatccaaat tgtaagattg actgggacca gcccattaaa ctcgcaaaaa 2602981 aagcagaaga gcgttaaacg cttttctgct ttttataaat caaacgggct gtagtaaata 2603041 gcgatgagaa tcgcttctat taccagaaga agcggtactc cgtacttaaa agaagcgtgt 2603101 ttcgttttat gtctgaaggt ttgcatgcca agccagacac cgagcgctcc aaacacgatg 2603161 gctatcagcc acagccggtc ttcagaaatt ctccacttgt gctgctgcgc tttgcgtttg 2603221 tcaatgccca tcacccaaaa accgcacaga ttaatcaaca ccaaataagc agcaataatc 2603281 atgttgcctc atcctttata tagaaaaagc cgctctgctg gagagcggct ctatatgatt 2603341 acttgtttaa ttgagcttta gcagcatcag caagctgatt gaatgcagta agatcgttta 2603401 cagcaagatc agcaagcatt ttacggttta cttcgatacc agaaagctta agaccgtgca 2603461 ttaaacggct gtaagaaagg ccgttcatgc gagcagctgc gttgatacga gtgatccaaa 2603521 gtttacggaa atcacgtttt ttctgacgac ggtcacggaa agcatagttt ccagatttca 2603581 tgacctgctg gttagctact ttgtataatg tatgttttga accgaaataa ccttttgcta 2603641 atttaagaac ctttttacga cgcttacgtg taacagttcc gccttttact cttggcattg 2603701 aatttccctc ctaattgttc cttatccgat tacttgatgt tagcaagcat ttgtttgata 2603761 cgtttgaagt ctcctgcgct tacaacagca ctcttgcgaa gcttacgctt ttgcttttga 2603821 gatttgttgg cgaataagtg acttgtgtac gcgtgagaac gttttaactt cccagaacct 2603881 gtctttttaa aacgtttagc agatccgcgg tgagttttca tttttggcat gggatttcct 2603941 ccttattgct tttcgttttt cggtgcgagc attaagaaca tgctgcggcc gtccattttt 2604001 ggttttgttt cgactgtcgc aacctcagca catgcttcgg agaaacggtc taatacacgc 2604061 tgaccgattt ctttatgagt gattgcgcgt cctttaaagc ggatagaagc tttcacttta 2604121 tcgccttttt caaggaattt aatcgcattg cgcaatttcg tgttaaagtc atgctcatcg 2604181 attgtcggac ttaaccgaac ttcttttaag ttaatgattt tttgattctt gcgtgcttct 2604241 ttttcctttt tctgctgctc aaatcggaac ttaccgtagt ccatgattcg gcagacaggc 2604301 ggttttgcat tcgctgcaac taacacaagg tcaagatttg cgcggccggc gatttcaagt 2604361 gcttcctgac gggacttgat tccaagctgg tcgccatttt gtccgattaa acggacctca 2604421 cgtgcacgga taccctcatt aaccaattga tctttgctaa taatgagcca cctccatagt 2604481 ttcttcgaat tgattcacaa ctcattttga atgcattttg caggcaaaca aaaagtgtgg 2604541 gcattataaa acacccacac tacgaacatc tgtatcaata aaaatgtacg gtcaacctgc 2604601 caactacatg catgtgtcaa tcaggtgaga agcgggtgct tctgcttgtg atttatattc 2604661 aattcaataa ctattctaca caataccgga tctttagtca aggacgactt atccggaaca 2604721 acttttacat tgtaacatgg gttttctatg agcgcaagag agaaaaagaa aatctttcat 2604781 ccccacccag aatacaaaga accaacaatt cccccttatt acgcaattta caacaaaacc 2604841 accgacagga agaaatgtaa aacaaagtta atctctgacc gatataagga gcagaaggga 2604901 gcctgacaca tgaacaaact gatacagctt gctttatttt tcacattgat gttaaccggt 2604961 tgctcgaata gcagcacatc ttccgaatca aaagtcgaaa ccactgttaa gacaacggca 2605021 gcatttcctc aaaaggagct ggagaaagag ctaaaaaaac taaaacccgt ttcattggac 2605081 atgaagttcg agagtccact cgctaccgag ttaggaaagc ggaaggcaaa agaggaagct 2605141 gaaaagcaaa gacaaatcgc cgctgagaaa aagcttgaaa aagagcggga ggcgaaacga 2605201 aagaaacagc aggaggaaaa agcggagaga cagcgattag cagagcagca ggctgcagag 2605261 agacagcgat tagccgaagc ggaaagacaa gctgaacttg aaagacagcg gcaggcagca 2605321 atccaaaaag agcagaaagc gaacgctgag aaaaagcggc aatcgcaggc acaacggcag 2605381 cagactgagg caccctcatc taatagtcaa gatccaccat cttcctcgag tcagacagat 2605441 aaaaccattc aacagccagc ttcagagctt cctgatgacg atggttatgg ttatgaagaa 2605501 cgaaaaaagt ggcatgacga tcaagtagaa tggggcatta aacaagggta tatcgatccc 2605561 gaagacgcac cataaaataa aaaaagccaa ggcattcagc cttggcttat cctccgatca 2605621 gctgcacgaa cacagggatg accagaaccg ttaccactcc tactacgaca acagcaatac 2605681 ttgccatcgc agcttcaact tctcccatct caatcccgac cgctacacca agtgcatgtc 2605741 cggatgttcc aagagccaat cctttagaaa tcggattttt cactttaaac accttcaaga 2605801 acaatgctcc gagcgcatat acgatgacag cgttaaagat gaccgcaaag gctgtgatgt 2605861 cgctgatgcc cccgatgcct tttgataaag gaagcgcaat tgccgttgta gccgcctgcg 2605921 gaagcatgct tttcattacg gccgaatcga gatgaatgcc tttagcgagc agataaacaa 2605981 tcgtgacaga gcagatagag ccggcaataa tggaggccat gatttgccac cagtactttt 2606041 taagcttatc tctttgtttg tacaaaggaa ttgcaaatgc gatcgttgcc ggttcaagaa 2606101 aaaacttaat gatctctccc ccgttattat aatccgcgta ggaaaaaccg ccgattttta 2606161 aaaatgcgat ccccagcacc atggcaacaa acaaaggagt gaaaaggaag aagcctttcg 2606221 ttttcttaaa taaaaaggtg ccgatgccga atgcagcaag tgatacgaca atcccaaaat 2606281 aaggactcat tgtgctttcc atgtgaagaa cctcctgttt cccttaatgg tgaacgagtt 2606341 cgttattgtt ctgcgggctt tgcactgttt ttgttttcat gtccgcttcg gttttgcgtt 2606401 ttccgctcag cgacagaatc agctgagaaa acaatcccgt agcccccagc aaaataatcg 2606461 ttgcgagcag aatgacaaga acaatttgca ggccgtattg ctgcatcaca ccaagcgaat 2606521 tcataacaga tatacctgat ggaacaaata aaaatccgat cagagaggtt aaagacgttc 2606581 cgagcgtctc cacttgttcc agtttaatga ctttcaaaca taataggaga aataataaga 2606641 ccaaccctac aaccgatgcc gggataggta ttgggacaat agcggcaatc atatttgaaa 2606701 ccagcataat gacggcaaaa ataaatgctt gtgttaaaaa cccgtacact tttttagcac 2606761 tcattttctt cacctctttc tctttggtac cctcattata aataagaatt ccctgttata 2606821 aagcgcttac aagataacat gccgtatagc gggtctgagt tgcagaatca aatggctgaa 2606881 atgcaaaaag ccgcccatca aatatggagc agctttttca attccttcgc atatgtccgg 2606941 ctgaccggta ttttcgatcc gtctttcatg atcagattat acgttgaatt aaaccatggc 2607001 tgaatttctt taatatattc agtattcacg acaaagctcc gatggacgcg gataaaatca 2607061 gaatccggca gctttttctc aatcacaacg agtgtatcgc tgaccgtata agaatgatcg 2607121 aaggttttta cattgacatg accatcttct gttccggcat agataatgtc cttcgtatcc 2607181 acaatcacaa tcgattcccc cacagatagc gcgagcttgt gctggccggc atggctgttt 2607241 tgctctgttt ctacaatatc ccgattgact tttttatatt ttttcagcgt ttgctgaatt 2607301 ctttcttcat cgaaaggctt ggttaaataa tcaagagcgt ccacctcaaa cgctttgagc 2607361 gcatactggt catacgctgt cgcaaacaca atagcaggag gatgcttcat tttcttcaat 2607421 cgctttgcga tatcaaaacc gttttctccg gataaatcaa cgtctaaaaa cagcaaatca 2607481 ggtttttgat ccatcatttg gtcaaaagcg gattcgatat tttccgcttc attgatttcc 2607541 atttcatcat tggtccgctt aagcaagtaa gccagttcat cccttgccag catctcatca 2607601 tcaactatta acaccctgag catgttcttc tccctctttc atctgttgca ttggcacttg 2607661 aaaggaaacc tctgtccctt tatgaacctc actgctgata tgcagtgcag cctgctgtcc 2607721 gaataaaccg atcagccgct gatttaggtt ataaagcgct gtaccggttc cctccttaga 2607781 cggaaacggt ttcttcccca gttccggcaa gacgtccggc ggaattccgc gtccgttatc 2607841 cgccaccttc atatagacgg atgcatcatc agataagaca cagactgtaa ccttgcatat 2607901 gtcttgtttt ttcggaaacg cgtgccgaag cgcgttctcg acaagcacct gcaaaacaaa 2607961 cggagggatt tcaatctgct ccagtctgct gtcgatatta agctcaattt tatatttccc 2608021 gggaaaacgc gcctgttcta atgacaaata ggcgttaaga tggttcagct cctttgagag 2608081 cggaatcagc agctgtctcg ctccttgaag gtttgaacga aaataaacac tgagctgcaa 2608141 taggagctta cgggtttttt caacatctgt acggcataac gcagaaatcg tgttgatcgc 2608201 attaaataaa aaatgcggat tcacctgtgc ttgaagcgct ttaatttcag catccttgag 2608261 aagtttgctt tgcagctctg cttccccaag ctcaagctgt gtcgaaaaca gcatggccag 2608321 cccctcggca agttcctcct ctacctgact caggcctgcc gggcttttaa agtacatttt 2608381 taaggtgccg attgtattgc cgttcgatgt cagcggtagg acaattgcag cgtgcaaagg 2608441 gcattcagca tgcgtgcatt caatctcttc ctgcgaaatc gccttcataa tatgccctgt 2608501 tttaatcacc tttttggaca ggccggtgat caagcttttc gatgggatgt ggtgatccat 2608561 tcccgcaccg acatgcgcaa ggatcttttc tttgtcagtg agagacaccg catctgttcc 2608621 tgtcagctta tggataatag ccgctacact tttacaggag ttttcattta atccttggcg 2608681 gaaaaatgga agtgtctgat cagcaatcgt aagcactcga tgcgtttcga gagcccttgc 2608741 ctgttcttcc ttgcgaatga tcgcttgaat aatagacaga aaaataaaac tgcctgttcc 2608801 attgatgagt atcatcggaa ttccgatcat gctgacaagc tcccaagcgt cactgaacgg 2608861 ctttgccatc agcaaaataa tgatcatttg cagtgactcc atgccgattc ccacaagagc 2608921 ggcgatgcgc ggtgtcggca ttcgatatcg cttcgtaaaa tacctgccga tcaagcctgc 2608981 aagaacaccc gctaaaatag atgagacggc acagcttaag gccgtgctgc caccgagtga 2609041 aaaacgatgc aggcccgcaa gtatgccgat cccagcccct acaaaaggac ctccgagaag 2609101 gcccccgatt tccacgccca aaatacgggt attcgcgata gagcccgatg gatctatcgt 2609161 aaacacccag tcattgttta caatcatatt tctttgaatt tcgatgcctg tataattgct 2609221 gatgatgctg aaaagagaaa aaatagaaat taaaatcgct tttcctttat agccgtcctg 2609281 attctgaaga gcttgtctga aaagtttcgt atgggcgaga atgaacccta atataacaat 2609341 aatccccact ctctccagca tcataatcat taaatgaatc attcatgtca cctgttcttt 2609401 ccgttttcat tctagcatgt tttcgttttg cggctgactg tttttttaaa atcgtctgaa 2609461 aacatatttc acaaggcttt tatctattgt aaaataaaac atgagccttt tggcagaaag 2609521 atttgaatct gaagcagagg agaagatcat gaaagccgta ttttttgatt tagatgatac 2609581 actactttgg gacgaaaaaa gcgtcagaac aacatttgca gaaacttgct tacaggcgga 2609641 gaaaaaatat ggccttgccc ctgaggaatt cgaagcagct gttcgcgaag cggcgagaga 2609701 attgtacatg tcatatgaga cgtatccata tacagtgatg atcggcatta acccgtttga 2609761 aggactgtgg tccaatttct cagagccaat cagtgaaggc tttcaaaagc tgaacaagat 2609821 tgtgccggag tacagaagaa atgcatggac caacggactg aaagcgcttg ggatcgatga 2609881 tcctgcatat ggcgaatact tgggagagtt ttttgcggca gagcgcagaa agcgcccgtt 2609941 tgtatatgat gaaacttttg ctgtactcga tcaattaaaa ggcaagtatg aattattgct 2610001 tttgacaaat ggcgatccta gtctgcaaaa ggagaagctt gccggcgtgc ctgagctcgc 2610061 tccttacttc aatgaaatcg tcatctcggg cgcattcggc aagggcaagc cggatgtttc 2610121 aatttttgaa cactgcctta agctgatgaa tattgaaaaa gacgatgcca tcatggtcgg 2610181 cgataatttg aatactgata ttttaggcgc ttcaagagcc ggaatcaaaa ccgtttggat 2610241 caaccggact gataagaaaa acgaaactga cgtaaagcct gattacatca tcagcagcct 2610301 tcatgatttg tttcctatat tagagaaata aaaaaagcat gatctcttca atgagatcat 2610361 gcttttttat tttatttttt cgcttcagct actgcctttt tcacaaactc atcaagtgaa 2610421 atggtttcag agttctgttc tccgtattta cgcacgttta ccgctccgtt ttctgcttct 2610481 tggtcaccga ccaccagcat gtacgggatt ttttgcattt gcgcttcacg gattttgtag 2610541 ccgatttttt catcgcggct gtcgacttca acacgcaggc cttcacattg caggcgttcc 2610601 tgcacttttt tcgcgtagtc taaatgcaca gccggagaaa ccgggatgac ttggaactga 2610661 accggtgcaa gccatgtcgg cagcgcgcct ttgtgttctt cgattaagaa agcaacaaag 2610721 cgttccattg ttgaaacgac acctctgtga atgacaaccg gacggtgctg cttgccgtcc 2610781 tcaccgatgt atgtcaggtc gaaacgttcc ggcaataaga aatcaagctg aaccgtagac 2610841 agtgtttctt cttttccgat cgcagttttc acctgaacat caagtttagg tccgtagaat 2610901 gccgcttcac cttctgcttc gtaatagtcg tggccgattt catccattgc ctctttcagc 2610961 atggattgcg ctttgttcca catttcatcg tcatcaaaat atttctctgt atcttccgga 2611021 tcgcggtaag acagacggaa tgtgtaatca cttaaaccga agtcttcata aacatcctgg 2611081 attaaacgga ctgtacggat aaactcatcc ttaatttgat ccgggcgcac aaagatgtgt 2611141 gcatcattta acgtcattcc gcgtacccgt tgaagtcctg acagcgcacc tgacatttca 2611201 tagcggtgca tcgttccaag ctctgcaata cgaatcggaa gctcgcggta actgtgaatg 2611261 tcttgtttgt aaatcatcat atggtgcgga cagttcatcg gacgcaatac aagtgtttca 2611321 ttgtccattt ccatcggagg gaacatgcct tcctgataat gatcccagtg tcctgatgtt 2611381 tcatacagct ctttgctgcc tagcacaggt gtgtatacgt gctcatagcc gaggctgatt 2611441 tctttatcga caatgtagcg ctcgatgacg cggcggattg ttgcgccttt tggcagccaa 2611501 agcggcaggc cttgtccgac tttttgagag ttcgcgaaca gctttaattc tttgccaagc 2611561 tttctgtggt cgcgttcttt cgcttcttct agcatacgaa gatgctcttc aagatcagct 2611621 tttttgaaga aagctgtacc atatacgcgc tgaagcattt ggtttttgct gtcaccgcgc 2611681 cagtatgcgc ctgcaaggct taacagctta aattctttga tttttccggt tgaaggaaca 2611741 tggacgccgc ggcacaggtc aaagaattcg ccttgctcat agatcgaaac ggtttctcct 2611801 tcaggaatcg catccaatag ttcaagcttc aggtcgtcgc cgatttccgc aaaacgggct 2611861 ttcgcttctt cacggctgac ttcttttcga acgatcggaa ggttcgcatt aacgattttt 2611921 ttcatttctt tctcgatttt cggcagatcc tccggtgtaa tcgcttcgtc catttctaca 2611981 tcgtagtaaa aaccgttttc gataaccgga ccgacgccga atttaacatc cttgtagatg 2612041 cgtttaatcg cttgagccag caagtgagcc gcactgtggc gcataatttg aagaccttct 2612101 tctgagcctt ctgtaatgat ttccactgta ccgtcttcat tgatcggcgt tctcaaatcg 2612161 atttcttttc cgttcagttt tccggctaat gactttttct ttaatcccgg actgatggat 2612221 gccgcgatat cttctgttgt tgttcctttc gcaaactcct tgactgctcc atcaggaaat 2612281 gtgattttta ccatatctga catctttgtc actccttttt ttgcatataa aaaccccgcc 2612341 ccctatgaaa gggacgaggt tgaataaacg gaatcgtggt tccacccttt tttccgcaaa 2612401 gccaatacac ggcacctgcg gctctaagct ctgtaacggg agttcccgtc agccattact 2612461 gttccttttc aagaggttca cagctgaagt tcaaaggcgg taaagcgaat ggtccttagc 2612521 tgggaagctt gcagccaggg cttccctctc tttgagccgg tatcattcct tcgtgtcctt 2612581 atcaatacgt gtgtctttct taatctccta tgtattataa attgttcaat ccaaaaaatc 2612641 aacacgatcg cgtttccttt tttttaaacc gacagcctta aatagacagg ctgccggccc 2612701 tcatccttcc gagtgcttca ccggtatttc tgcatctgta aaagcatgca gcgggagcat 2612761 ttccactctc tcttgaaata cgttttgaat ggtccttgcc atcatgtgct cgggctggtc 2612821 ggtataaagc acgacttcat caggcgcaat ggaaatcagc ggcgcgagca aatgagaatc 2612881 aatatacata ggatgatccc ggacaaatct tctgtctatg tatttcattt tttcccgttc 2612941 cggcacatag cgcagctccc ataatgtaaa ggaaccatca tggacaatat gcactttttt 2613001 gattcgcggc tgtttggcgt ccacatagtc tctgagtgtt tgaataaagt tttgatattc 2613061 ctgttccatc ttatattcat caatcgctgc ttctgtaata tctctcagct gcttatagta 2613121 tgatccaagt cggaaggtct gaaaggagcg aatgtaaaat actccttcct ctaaacagat 2613181 cgtttggagt tcatccaaaa ttgattgttt ccgtgaaagc ttcagcggct caaacggaag 2613241 atcgtctgct tcaccttcaa taatactgtg tgcgagctga aggatttgct gctgttcatc 2613301 ctggtccgtg aaacaatacg tttcctcaat caatgacagc atatgctcgt cttctttgca 2613361 ttccaaaaaa aatttgacca gaatcggctc cataaaacgc tgaataggaa aagccggatt 2613421 cgctttttca atcccgattt ttcgtatgcc ttcacggaca atgatattgt tccgatcgtc 2613481 cgaatgctga atgagatgta aaaaagcggc tgcatcatgg tcatcttcaa agattatttc 2613541 aagcatgttt gtcccccctt acggcatctg ttacaagtat atgggggatg tttttaaaat 2613601 agacgtaaag gtcattggca aatcttaatt tgattcttgg aacaagtttt gcattttctt 2613661 tctgaagatg aacggcaatg agataaacac gatatacaaa gcgagcacca taaagaaagc 2613721 gggcagattg ccagccaaaa agctcgcacc cagcacatta agcgcaatcg tcccagggat 2613781 gattcccaca gccgttgcgg caaaatacgg cagcgctttg acattggaaa ggcctgccgc 2613841 atagctgacg aaatcaaaat tgatcggcag gattctcaaa agaaagatat agaaaaatcc 2613901 gttatcctcc atttgcttct gtatggcttc aagcctttcg taatgcccgt tctttttcgc 2613961 cgaaaacaaa ccagccgcaa aaaacgaaac agctgaagcg cacatcgaac cgaataacgt 2614021 ataaagcgtg ccgagaagcg ggccaaacgc aagtccgcca gctattgaaa taacagacac 2614081 cggaaataaa acaagtggcc tgacgatgga tatcccgata aacatcagag gtgcaaagac 2614141 tccgaacgac aatacccata ccctgatttc tttcggcgat acattcaaat acgttttatt 2614201 tccccaatag agtaaaccag cacctgcaag cactgccagc catttgacag ccgtttttcg 2614261 tttcataccc tcagttcctt cccctttgaa ccacagcaat tatggatgtc ggcggttttc 2614321 tccgtcaagg cggatcggag cagccaaata taatatccgc tccattaatc ttgcagcttt 2614381 tacttcttct ttttctcccc tctgcgaata cgtaaaatga tgcttcagct cgtcaggtga 2614441 gaaattagaa gaaaagaacg ttggcagctg ctgggacatt ctgtgctgaa gcaccgttcc 2614501 gatgacctca tcccttaccc agcttgtcat tgattctgct ccgatgtcat caagcattaa 2614561 tacgggtgtg gtctttacca tattgagctt ctcttccaat gtctggtctt gcagcgaatt 2614621 cttaagctct ctcacaaatt caggcacata aacaatcatg gaggaatact ctttttccgc 2614681 cagctcattg gcaattgcag cgagcataaa cgtttttcct accccaaatt tcccgtataa 2614741 atataatcct ttcccttttc ccgtctcatt atagcttttc aggaagtctg taacatgctg 2614801 aaacatcgcg agtctgcttg ggtcactgat atcaacttgc tggaacgtcg ctccaagaag 2614861 atcctgctgg atatacatgc ttttcataag agactgttgt ttcttctgct ggtcgagctt 2614921 ccgtttgact ggacattcgt aatactcgat atcaatagac ctcccattga caacaagctt 2614981 cggatggtag ccctccaaca aattgttgca gttttcatct tccgaacaat aggagcaatt 2615041 cttgctttgt tcgatatatt cataaagctt atttaagctc ttttcgatca ttttttggtc 2615101 aatcacttct tcgttttcct tcaaaaatgc ttgaacatct tgatctttca tgactttttc 2615161 cttcatttgt tcaagacgtt tttggaaatc cggcctgccg gttacgccct gcagggaacg 2615221 gccgattggt tccatctatt ccttcacccc gcatctctgt ctttaatagg cagagtattt 2615281 tttcagtttt tgcatttctt ccatcatctt tttcttctgt tcttccaaat cctgcggatg 2615341 cagcttctgc tgtccggatt ctgaatcgga cgctgtttcc ttttctgtca tccaatcagg 2615401 aagcttttct tcacgaatca ctttttggtt tcgtttcgaa gactttgttt ttccctcagc 2615461 ccattcaaga tactggcggt tttcttctat tgcgagcttc atcgcttccc tgaccgtttt 2615521 cacctttttg cgtgcccaat gcgaagcgat tttttggata tagtttttcg acagcttcat 2615581 gtcggttttc agcatgacat aataaattaa cacatttgtg acgcctggct cgagcttctg 2615641 ttcgaacata atttcttcta tgatcttcag atcagctttt gacggctctg ttccgtcagc 2615701 aatgtcctgc agaagcttct tcggggaaat cgcctccagc aatgcaatca gcttcccatc 2615761 cagagaatcc tcttctgccg gttgttcgcc ttcacgcaga tgcaccggct gtgttttttc 2615821 caccaaatcg ggcagctgtc cgtttctttc aatttgatac cagtcgctcg ccgcttttct 2615881 taatgcctcc gtcgtaatga cgtcacgctc atcaattgcg ctcatcacaa cattttgcat 2615941 ttgcaaaggg tcaattccgt acagataaga aagctttttg attgtgtccc gcacctgctg 2616001 ggtcatcgct tttctcggta tcatcgtctc agaaagtccc gctaaaaaca aatcaaaatc 2616061 aaacacatcc tccgttatgg tgtaggacgg agactgtccg acagaagtat actcggaccc 2616121 ctcggcaagc cttaccgttt cctccatatc ggatgtgagc ttccattcac tcggctgcag 2616181 cgattcaaac gcatgattaa acggacgcgt aatgtccttc gcatcttctg aaatggccgg 2616241 gtgcgtaaaa aattgtttta attgctgata tttcgttttt ccgaccctat tatacagaaa 2616301 aacattcagc attccgtctt caaaaaattc atttggtctg agcggcggaa ggagttcata 2616361 tataaagagg cgctcctgcc gctcggattc tttcatatat actttcagca atccgatgcc 2616421 ctcgagcttc ccctgttcct gatggatcgt ttttaagttg gactgtgtca tccccatcag 2616481 ctgtctatgt gtggactctc cgccccacag acggttttgt tcaagctctc cccacaatgt 2616541 catataaaga gagaatgcaa cagggccgat taagggctgg tacagttgtg taataatttg 2616601 tctgtcaata tcctgcagca tcgatctgct tttaaccaca tacgggtcta caggcagtac 2616661 atctttccaa tagtcagcca tacattctca aaccttccga atttgtttct acctttcatt 2616721 ttacaccgtt tcttatatct atcaaatgcc aattttgcac atgagaaaag agctagaaga 2616781 atcctcttag ctcttttaac gctctttctt tattaagtct tttaattcat cgataaagac 2616841 gtttatatct ttaaactgcc gatagacgga cgcgaaccgc acatatgcga cttcgtcaat 2616901 cttagccagc cggtccatga ccatttctcc gacgagctca ctcttcacct cggagcagcc 2616961 ttgattgcga agttcttttt caatatcaaa gcacatgtct tcaagcgttt tgagtgaaac 2617021 aggccttttt tcacatgctt ttatgaggcc gcgcagcatt ttttctctgc tgaattcctc 2617081 acgcacacct tcttttttca caacgatgag cggggtttcc tccactttct caaaggtcgt 2617141 aaaccggtag tggcaggatt cgcactcgcg tcttcggcga atcgactttc cgtcatccac 2617201 aggccgtgaa tcaaggactc gtgttccgtt atgctggcat gaaggacatt tcaataaaat 2617261 cagctcccaa ctatatcgtt ccctgcaatg tattttcggc agcctccgcc ttttaaaaat 2617321 agatgtgaca gcatctgtcg ggagagccgt tgttaaattt gtttctatag cattaggtgg 2617381 tttgtgaaaa tctccttctt attttacaaa aaaaatgaaa aaagaaaaag ctgacactct 2617441 cgtttcttta taaaaataaa aggagcataa gctaaaaagc gcataatggc tttctagctt 2617501 cagctccctt tgtgttcgca atttacttta tagtactttc gcttgcgcct gtttaatttg 2617561 cacaggcccc attcctcttg gtatttcaat gttttctctt gtatcagcat gtaatgcctc 2617621 tgcaatgtaa tcagcagcga cattaggatc taagtctcca caagtataaa catcaatgct 2617681 cgcatatccg tgctcaggaa aactgtgaat cgttaagtgt gattcagaaa taatcacaac 2617741 tccgcttacg ccttgcggtg caaatttgtg aaatgcaacc tcgcgcacct cagcacctga 2617801 ttttagagca gcatttacaa acgttttttc aataaaatcc atgtcattca gcttatcaaa 2617861 atcgcatccc catagctcgg agataacgtg acgccccatt gtttccatag tcatggaccc 2617921 cccttaacaa gaattaaaaa gtgaaattcc aacaactggg tcggccattt accacggggg 2617981 aaagttagtc cggagaggtc ctaacccttt aagtaattcc gaaacagtct caagcaagaa 2618041 gttcacgaaa aatagtatac tgtgtttaag tctaatttgc aaggtgcgtt ttttcagaaa 2618101 tatgctgtta agggtttttt ctttaaaatg tgtccatgac cttattttat acagcagacg 2618161 gatgtttcat tcgtgccgct acatggcgga ttagatcaac aactctgcag gagtagcccc 2618221 attcgttgtc ataccacgcc agcaccttta ctttcctgtc ttccattacc attgttgtaa 2618281 gcccgtcaat gaccgctgaa tgcggattcg tattataatc agtcgaaacg agcggttcat 2618341 ctgagtaatc aagtacaccg tacatcgacg ttttggcagc gcgtttaaat gcctcgttta 2618401 cttcttcagc cgtaacatcc gttttcagat caacaacgag atcaaccaat gagacgttcg 2618461 gaacagggac acgcaaggcg aggccgtgaa gttttccttt cagatgcggc agcacaagcg 2618521 aaagcgcctt tgccgctcct gttgttgttg gaatgatgga ttcaccgcaa gcccgcgccc 2618581 ggcgcaaatc tttgtgcggg ttatcaatat ttttttggtc attcgtatac gcatgaactg 2618641 tagtcatcag accgctctca atgccaaact cttcatccag cacttttaca acaggcgcaa 2618701 ggcaatttgt cgtgcatgac gcatttgaaa taatgacatg gcgctcagcg tcgaattggt 2618761 cctcatttac gcccatcaca atggtaacgt cttcattttt tcccggagcg gtcaaaatca 2618821 ctttttttgc acctgcttct atatggccca tcgctttatc tttagcatta aacttccctg 2618881 ttgcttcgac gactatgtca atatcatatt cccgccaagg cagctgtttt ggatcacggc 2618941 tgtttaacaa aagcactttc tttccattta cgatcaggct atcttcacca gccacaacct 2619001 ctttgtcgta tctgccgtga attgtgtcat actttattaa atgagccagc gtttctgcgg 2619061 aatagctggc gttaatggcc actacttgaa tttgatcgtc taacatcgct tttctaaaaa 2619121 ccattcttcc gattcttcca aacccgttga tcgctacttt taccttcatg ttggacaccc 2619181 cttatcaatt atgccatcct aatttgttac tatctaaaat tagtataaca cattaaaaca 2619241 aattcgccag tacatattga taaaaatcaa cgattataac gctaatttat gatgcatctt 2619301 atgttttctt gcacagaata tcaggcgtaa gaaccaaaaa gcagccagcg ctccgcactg 2619361 actgccctca tgctttatga ttcctgtttt aacttatcat tgagcacact ttcttctagc 2619421 acagaaaatg tatccccgta cactctgtta atatgattcg ctccccaagc acacagcata 2619481 tctaaaatcc cttctaagct gcggccgtat tcgctgagct cgtattccac tttgggagga 2619541 acttgattat atacgattcg gttaatgaca ccgtccgctt ccagctcgcg cagctgctga 2619601 gtcagcattt tttgcgtgat attgggcatt aggcgtttta attcacttgt gcgttttttt 2619661 ccgtgcgtca gatggcataa aatgacgcat ttccatttcc caccgatcac ttcaagagtc 2619721 gcttcaacag aaatgttata ttttttcttc tccatacaat ccattctcct cacaggcacc 2619781 aaaaagtgac tatagcactt caaagtacgt acttttattt cttaacgata tgtttcataa 2619841 tcacatttgc cggctgattt gaatctgctc ttttttattt atatagctta ctcggcagaa 2619901 tttcaatcat acaacacatc ttacaaagga ggaacatcat gacttcagcc aataaaagca 2619961 atattcctgc actactggct ttggccgtaa gtgcattcgc aatagggaca actgaattta 2620021 tcagtgtcgg ccttttgccg ctcattgctg atgacctgga tattcccgtc acgacagcag 2620081 gattgaccgt ttccctttat gcgctcggcg ttacatttgg ggcacctata ttaacttcat 2620141 tgacctcaag catgtcacgt aagacactat tgctttggat catgtttatt tttattgccg 2620201 gtaatacgat ggcagcaacc gcttcaagca tcgggatttt actagcagca cgtgtgatat 2620261 cggcattttc gcacggtgtg tttatgtcga tcggttcgac aatcgcagcg gatattgtcc 2620321 cggaggataa aagggctagc gcgatttcaa ttatgtttac tggcctcact gtggcaactg 2620381 taaccggagt tccttttggg acatttatcg gccagcagtt cggctggcgt ttcgccttta 2620441 tggtcattat cgccgtcgga atcattgctt tcattacaaa tggcattctt gtaccgtcca 2620501 aattacgaaa agggacgaaa acaacgatgc gggatcaatt gaagcttgtg acaaacagcc 2620561 ggttattgct tttatttgtc attacagcgc ttggatacgg aggaacattc gttgtgttca 2620621 cgtatctgtc tcccctgctt caggaagtaa caggcttcaa agccgggact gttgcagtga 2620681 ttctgctcgg atacggaata gctattgcta tcggcaatat gattggcgga aagctgtcaa 2620741 accgaaatcc gattgccgct ttattctata tgtttatcgt acaggcaatc gttctattcg 2620801 tactgacatt tacagccccg tatcaagcag cagggctcat taccattctc tgtatgggat 2620861 tgctggcctt tatgaacgtg cccggccttc aggtgtatgt cgtcatgctg gctgagcgtt 2620921 ttgtcccgag tgcagttgac gtcgcatccg cgatgaatat cgctgccttt aatgcaggga 2620981 tcgcgcttgg gtcatacctt ggcggtgtga tcaccgattc aatcggattg attcataccg 2621041 cttggatagg cggattaatg gtggtcggtg cagtcatttt aacaggctgg agccgcttga 2621101 tggaaaaacg agatcggcag gaagcctgac aattttaaag gaggaaataa acatgacaac 2621161 acatttacaa gcaaaagcaa cacttcataa tggggtagaa atgccttggt tcggcctcgg 2621221 cgtgttccaa gtggaagaag gatctgaact ggtaaacgca gttaaaactg ccattgttca 2621281 cgggtaccgc agtattgata ctgcagcaat ctatggaaat gaagctggag tcggagaagg 2621341 gattcgggaa ggcattgaag aagcaggcat ttcaagagag gatctgttta tcacatcgaa 2621401 agtatggaat gcggatttag gctacgaaga aacactcgcc gcgtttgaaa caagtctgtc 2621461 caaactcggt ctggattatt tggatctata cctcatccac tggcctgtag aaggaaagta 2621521 taaagaagct tggagagcgc ttgaaacgct gtataaagaa ggccgtatca aagcgattgg 2621581 cgtaagcaac ttccaaattc accatcttga agatctgatg acggcagctg aaattaagcc 2621641 tatgattaac caagtggaat ttcacccgcg cctcacacaa aaagagttga taagatactg 2621701 ccaaaatcag ggcatccaga tggaggcttg gtcaccttta atgcagggac agctgctgga 2621761 tcaccctgta ttggctgaca tcgctcaaac atataataaa tctgtcgcac aaattatttt 2621821 gcgctgggat ctgcagcatg gcattataac gattcctaaa tcaacgaagg aacaccgcat 2621881 taaagaaaat gcaagcgtat ttgactttga attaacgcag gatgacatga accgaatcga 2621941 tgcactgaat gaaaacttgc gcgtcggtcc tgatccggac aactttgatt tttaatggcc 2622001 aaaaaacacc gttcaatatg aacggtgttt tttgtattat gcccagctgt tcatgatttc 2622061 atcaagctgc cttttggtct cttcaagcgt gccgctgtta tcaatgactt gatctgctct 2622121 tgctgttttt tcctctaagg gcatttgaga gcggatacgg ctgactgctt cttcttctgt 2622181 cagctgattg cgcttcatca gacgttccag ttgaagctct tttgtcacac tgaccacaat 2622241 aattttatca accaatgatt ccaatttgct ttcgaacaat agcgggatat ccaatacaac 2622301 aaatgcctcc cgatttgcaa cggcttcatc acggcgattg agcatttcct gcctgactgc 2622361 gggatgaaca attgcattta aagcgagacg tttttgttca tttgtaaata ccagcgctcc 2622421 aagctttttt ctatctatat cgccatttga gagcagtatg tcttcaccga attcgtcaat 2622481 gatttgccgg taggccggca tccctttttc taccgcttgt tttgcaatga tatctgcatc 2622541 tataactgtt attccttttt caatcagcat attggctacc gtgcttttgc cgctagctat 2622601 tcctcccgtt aaaccaatga ctaaggtcaa gagatccact cctttttaca atttccagag 2622661 cccaatcgtg attaatagaa gccccggcaa aaacgccatt ttatcgatcc atttccactt 2622721 agacagaaaa tggccggcat tgattccaat tgatacaaac agcgagctca tgattgccac 2622781 ggcgatgctc atcacaatcg gcgaaaaacc gagaatggct gcgcctatac ctgctccaaa 2622841 ggcatcaatc gataaggcaa atcccaataa gaccgcctca attccgttga tcacacccga 2622901 tttgtcgata tccgcactca tgggttttct caaaatatga atcacaattc ctaatgaccg 2622961 aacctctaga ttaagcagtg ttttttcatg caataggtat tctttatctt ttgccggttt 2623021 gaaaaattga tacagaaccc acgcaccgat tccaaccaat atcaaaccgc caagcttctc 2623081 cgtcacatat acaggaaaaa acttcgtgag aaagcttccg atcagcatgg atataaacat 2623141 gacagcaccg gaacagcagg cgataaccaa aatcgcttta aacggtattt tcatttttct 2623201 caatccgtac gtaaatccga ctgaaaaact gtccaagctg acagccaacg ccagcagcag 2623261 tatagaaacc atttgcatat ccgtttcttc ctttctgttg gtgctcttgt atcagatgtg 2623321 aaatgcccgg gattcatcac aatcatatat atgggaaagt gaaaaatccg tgtttcgaaa 2623381 atggcatcct taatccagag ttactgatat atgcaccgac agcttggaca atgaagcatt 2623441 atgctacttt tttgtctggc actttgcgca aaaatgcgtg cctcttcctc caacgacaat 2623501 tttcgaaatc atcgttccgc aatttttgca tggctcgtct ttttttccgt acacaaaatg 2623561 ctgcagctgg aacattccga tttccccttg ggagttgata tatgaacgga ctgtgcttcc 2623621 gcccgcatca atcgcctcct gcagagtgtt tttgatttca gcgtgaaggg ttttgattgt 2623681 tttatctgat aattgatttg cttttgtctc gggatggaca cccgctctga aaagagcctc 2623741 atccacataa atgttcccga gtccaactac cgttttttga tccagtaggg cagttttgac 2623801 agcgcggttt gttttcgcaa gccggtcttt taaatacgca cttgtaaatt cttctgcatc 2623861 cggctccggc cctaactgag aaagcgggag ctcgcccgct tcttctcccg gtttaaataa 2623921 gtgcatggtt ccaaatttcc gcacatccct gtaccggagc tgggttccat ccgtcatcgt 2623981 gaatatgaca tgcacgtgtt tatcgtcagg ctcctcggct tgatgaagac cgtattttcc 2624041 ttccattcga aggtgagaaa ccataacata atgatctaaa tgaaacagta aaaactttcc 2624101 ccgtcttccg atggactgta tcgtttctcc tgctagtttt cgcgcaaatt cctccggttc 2624161 ggcaggccgt ttgatgatat tcggccatct gatctctacc gatttgattg tttttccctt 2624221 tacaagcccg gtcagagtgc gccggaccgt ctcaacctct ggtaattccg gcacatccat 2624281 cacttcctat ctctgtttat ttcgcatcgt accaagatgg gcctgatgca aagtccacct 2624341 ttaacggcac atctaatgca agcgcatgct ccatcacttc aggaacaagc ttttcaagaa 2624401 tttcaatttc ttcctttggc gcctcaaaaa tcaattcatc gtgtacttga agcagaagcc 2624461 ttgctttcaa ctgtttttct ttcagcttgg cagccatgtc aatcatggct tttttgataa 2624521 tatcagcggc gcttccttga atcggcgtat tcatggccgt ccgctccgca aaacttcgga 2624581 tattaaagtt ccggctcgtc agctcaggga tgtagcggcg gcgatgcata agcgttgtta 2624641 cgtatccttt ttgtttcgct tcctgtactg aatcttccat gtacgctttt acgccttgga 2624701 agctttccag atagcggtcg ataaatgctc ccgcttcctt ccgggtaatg ccgaggttct 2624761 gtgacagacc gtaatcgctg atcccgtaaa caatgccaaa gttgaccgct ttcgcctggc 2624821 gtctcatcgc agatgtcact tcatccttag cgacatggaa cacatccatt gccgttttcg 2624881 tgtgaatatc catatcatta gtaaaagctt cgatcagatt ttcatccttt gaaatatggg 2624941 caagcacccg cagctcgatt tgtgaataat cggctgcaaa aatgagccag tctttttcag 2625001 acggcacaaa agcttggcga attttccgcc cttcctcaag cctgatcgga atgttttgca 2625061 ggttcggatc agtcgagctg agacggccag tttgcgttaa ggcctggtta aatcgcgtgt 2625121 gcactttatg cgaatccggt ctcgtcacct ttaaaagccc ttcgatatat gttgattgaa 2625181 gcttgccaat ttgtctgtac tgtaaaatat agtcgacaat atcatgcttg tcagccagct 2625241 tttcaagcac atcggcagac gtagaatagc ctgttttcgt tttctttacg acaggaaggc 2625301 cgatcttttc aaataagatg acgcctagct gtttcggaga attgatgtta aacggctctc 2625361 ccgcaatctc atggattttt tcttcatatt ccttcagctt cgcacccagt tcttcaccca 2625421 tccgttttaa acggtcaaca tcgaccttga cgccagttga ttccatttcg ccaagaataa 2625481 gcgcaagagg catttccagc tcttcaaaca gttcaagctg gtcgttgttt tccagctctt 2625541 gaacgagctt ttcccgaagg ctttgaatcg ctaacgcttt tcggccaagg tgctcagaca 2625601 gtacgtcttc tgacggcact gcccgttttg ctccttttcc ataaactgat tcatcacttg 2625661 aaacgatatg caggccgtaa tccttagcca cactcgcaac gtcgtcatat gaattgcccg 2625721 ggttgatgat ataagccgca aggagcgtat caaactcggc tcctttcagc tcaatgccct 2625781 gccagcgcaa agcgacaacg gcccgcttgc tgtcgaagac ccatttcttc tgctcgtcat 2625841 tttccaccca ttctttaaac acctcagact caacggcaat gtctttcgga atgaaataag 2625901 ctcccgtttc atttacgatc gaaaatccga ggatcggctc ttcatgataa ttatcgccaa 2625961 tctgttcaac gacaaatgcg gatggagaaa ccaatatatc gcttgtcacg tctgtgactg 2626021 ttttgacatt aatgtcttcc aacgattgat cctgttctgc ttctgcactg tcttctccaa 2626081 gccgttcaag aagcgtgttg aagccaagat ctttaaagat ggcaatgacc tgttcacgat 2626141 taaagccttg atattccagg ccggaaacag atacctcaat cggagcatcc gtcataattg 2626201 tcgcaagctc cttgctcatc aatgcctgat ccttaaactc ctcaagcttt tccttcaatt 2626261 tctttccgct cacctcgtca atggactcca gcagcttttc aacggaatca aattgtttta 2626321 aaagcttaat cgcagtcttt tctccgacgc cgggcacacc cggaatatta tctgaggaat 2626381 cgcccatcag acccttcatg tcaatgattt gttcaggcgt aagcccatat ttctctttga 2626441 catgctccgg tgtgtaaaat tcaacatcgg taattccctt tctcgtaatg gcaactgtcg 2626501 ttttgtccgt tgccagctgg gttaaatcct tatctcctga gaaaacctta acttcaaatc 2626561 cgtctttttc agccgatttg gccagtgtgc cgataatatc atccgcttca tattgttcca 2626621 gttcatagcg gctgatctgg taggcatcca gcagctcgcg gataaacggc atttgttcgg 2626681 aaagctcagg cggggttttc tgtctgccgc ctttatattc tttaaatgtg ccgtgacgaa 2626741 atgttgtttt cccggcatca aacgcaacca gcatgtgcgt cggtttttca tcctcaagca 2626801 ttttcatcaa aatcatcgca aagccgtata cagcattcgt atgaacacct ttatcattgc 2626861 ttaacagcgg caatgcaaaa aacgcccggt aagccagact gtttccgtct acaagcacta 2626921 atttttttcg ttccgtcatt caatttcctc ctaagaagcc tcaggcttcc attcatctct 2626981 tacatagtca ttagctcctc ttattttaac aaagttcaat ttgaaaggaa aatacgtgaa 2627041 ctataagaga agacacaaaa aaggacggga acacaaatag gttcccgccg tcaaaattgg 2627101 ctccttggat gaaggggttc tactacatcc taccagcata ggtttaacag tgcatgaaga 2627161 tattgttaaa cctttgtaaa cattaggcgg acttttcagc ggcccgtttc agcgtcacgg 2627221 taaagacagt tccccgtcca agctcgcttg tgacatcaat tttcccttca tgagcctcta 2627281 ttaaatgctt gacaatcgct aggcccagcc cggttccgcc cgaatttctg cttctgtctt 2627341 tatctacacg gtaaaagcgt tcaaagatgc gcggaatttc ttctttctga attccgattc 2627401 cagaatcggc aacctcaatc tgaatgtctt tttctctggg ctttacattg atagccacgg 2627461 agcccccctc aggcgtgtag gttaatgcat tgtttacgag attaagaaat acctgtttca 2627521 gcctgtacgg gtcaccagat acatattgag ggtctttcgg gacattcagg tgcaaggaga 2627581 tgcctttctc atccgcctta tgcttcagaa gcgtttcaat ctcaccaagc attttggccg 2627641 gctcaaacgt ttcgatactg agcgtgaaat tttgctgctc gatttttgag agatcgagca 2627701 aatcctgaac caaagactga agcctttcgc tttccttaag aataatagag agaaattcag 2627761 aaagcgcctc tttgtcttcc atcgccccgt ccaataacgt ctccgtaaac ccttttatgg 2627821 acgtaatcgg tgttttcagc tcatgagaaa cattggccac aaaatccttc ctcatctgct 2627881 ctaatttctt cgtttccgtc atgtcatgga aaacgagcac aattcctttc cattcatcgt 2627941 ccggccccat aatcggaacg ccgtccactt caaaataacg ccgttctatt ttgatcggca 2628001 gtcttaacag cttgcatttc tttgtctccg tcataaaaat gtcttcgaca agctggatca 2628061 cttcttcatg ttcaaatgca tcgtgataaa gacggcgcag catatgattc ggattgatat 2628121 gaaactgctt ggcgtaagac ctgtttacga gattaataaa gcctcttccg tcgatcataa 2628181 tcagcccgga gccaatgttt tcaatgactg tcagcagccg atcccgctgc atttcctgcg 2628241 ttcgcgtcat ttccatcaga tcaatggcaa ggctgttcat cgcatgtcct agcttatcag 2628301 aacgcctaat atagccgccg tacgtccgtg catcgtagtt gcccttagag agttctgtgg 2628361 ctacatttgt cgctgactca attgaccttt tataacgtga ggtcatgctg gaataaaaat 2628421 aaacaatgac gataaatgcg gtacaaagac tggccgtcag catcccccac aattcgcctt 2628481 ttaagccgtc gcttttttca gaggcggaaa gcagcacata tcctgttttt tcaccttcgc 2628541 ttctaagtga aagtccgtaa taaagcttgt tatctgttgt tgacagaata ccctcatggc 2628601 cagaaacaag cgcctgcacc ttttgggaat cagccgatct accgtttgac ccatacagca 2628661 ccttaccgtc tgtatcgata acggatgcgc tcacatcaag cgcgccgcct gcatctttaa 2628721 tgattttctc atttgcttga ttattcagat tgccggcatc aagaagcgaa gccaagtatt 2628781 ttgcttcttt ttcaatgtgt tcctctgctt tcctttgatc agatgtttca aaaagctgct 2628841 gtaaaaacag cccgaggaca caaaacacca gaatcataca gacaacgaat acagaaaaaa 2628901 ggcgcacacg gtatttattc attcattttt ggctcctcca gtttataccc caatccccta 2628961 atcgttttaa tgtagatcgg ttttttggta ttgttttcaa ttttgtcgcg aagatggctg 2629021 atgtgcacat caacaattct cgtatctccg gcaaaatcat aattccagac tgcgctcagc 2629081 agcaggtctc ttgtcagaac tctgccttta tgtctgccta aatagagcag cagttcgaat 2629141 tctttcggtg tcagttcaag ctgactttct ttaaagtacg cttcataatg atcaggcagg 2629201 attttcagat cgccgattac gatctggcct tccatttcat cgttcttcat ctcactagag 2629261 ggcgcagcta tttccgaacg ccttaaaatc gctttgactc tcgcatttac ttcccttgga 2629321 ctgaacggct tggtcatata atcatcagca ccgagctcca gccctaatac tttgtcgaat 2629381 tcctcatcct tcgctgtcag cattaaaatg ggaaacatca gtttttgctg tctcagctgc 2629441 ttgcatactt cgattccgtc caattttgga agcatcacat caagcacaat caaatcaggt 2629501 ttctctgttt ccgctttttt gagtgcttct tccccatccg aggcggtaat gacatcatag 2629561 cctgaccgtt ccaaattgta ctgtaaaaga gtaacaatag attcttcatc atccacaact 2629621 aaaattttct tgttcatgct gtgcctccag tattataatt ccccgacatc ctatttctct 2629681 attttatgtc atcttaacat gtttcatgat tttattttag cgaaagcagg acattccgac 2629741 aattcgcctt ttacatcatt tttaaaagaa ataaagacgt ttatgatagc gctttcattt 2629801 atagtaaaaa gagaaaggct gtattaagca agcctttctc tctttttatt aggataatac 2629861 tttcatgaca tttttgacag attcaactga tttattcagc tgcgctcttt catagtctgt 2629921 cagttcaagt tcaatgattt gctcaagacc gttgccgcct acaattgtag gaacaccaag 2629981 gtagatgcct tcatagccgt attccccttc aagataagca attgtaggaa ggacgcggcg 2630041 ctgatctttc aagatcgctt cgaccatttc tgtcagagaa gccgcaggcg cataatacgc 2630101 gcttccgttt ccaagaagat tcacgatttc gcctccgcct tttctagtgc gctccacaat 2630161 tgcgtcaatc cgttctttcg gaataagagt ttcaagcggg ataccgccag cataagaata 2630221 acgcacaagc ggaaccatat cgtcaccgtg tccgccgagt acgaaaccag tcacatcttt 2630281 cactgacagg tttaattcct ctgccacaaa tgttctgaat cttgccgtat caagcacacc 2630341 tgactggccg attacacgct ctttagggaa gcctgattct ttgtacaccg cgtatgtcat 2630401 tgcatcaaca ggatttgtca gcaccacaat aatagagtca ggagaatatt tcacgatttc 2630461 ctgcgtaacg cttctcataa tcttttcgtt tgtagagacc agatcatctc tgctcatacc 2630521 aggttttctt gcgataccgg ctgtaatgac aacaatgtca gagccggctg tatcctcgta 2630581 attggatgtt cccgtaattt ttgcgtcaaa gccttgaacc gggcttgctt caagcatatc 2630641 aagcgctttt ccctttgtcg ggttctccaa ttgcggaatg tcaacaagaa caacgtctgc 2630701 cagctctttt tgagcgatta aaaatgcagt tgtagctccg gtaaaacctg ctccgataac 2630761 agaaactttt ttacgagtat ttcccatgtc tctcttctcc tttatggcta gttttaggct 2630821 ttttccttgc ttagtccatg tttttgatca gttcttctcc gaactctgaa catttcactt 2630881 cagtcgcccc gtccattaat ctggcaaaat cgtaagttac gactttagaa gcgattgttt 2630941 tttccataga tttgataacc aaatcagccg cttcgttcca tcctaaatgc tcaagaagca 2631001 gaacgcctga aagaataact gaagatgggt ttactttatc aaggcctgca tatttaggag 2631061 ccgttccgtg cgtcgcctcg aaaatcgcat gtcctgtttc gtagttgatg ttcgctccag 2631121 gagcaatgcc gattccgccg acttgcgcag caagagcatc agaaatgtaa tctccgttca 2631181 agttcattgt cgcaacgaca tcaaactcgt ttggacgcgt taagatctgc tgaaggaaaa 2631241 tgtcagcaat gctgtctttg ataatgattt ttcctgctgc ttccgcttcg ctttgcgctt 2631301 tgttggcagc gtcttttcct tgttcttcag caatgcggtc atattgagcc catgtgaaga 2631361 ctttatctcc gtattctttt tcagcaagtt catagcccca gtttttgaag gcgccttctg 2631421 tgaacttcat gatgtttcct ttgtgaacaa gtgttacaga tttgcggcca tgctcgatcg 2631481 cataatcaat ggcagctctg accaagcggc ttgttccttc ttctgaaaca ggcttaatgc 2631541 cgatacctga tgtctcaggg aaacggattt tattgacgtt taactcattt tgaaggaagc 2631601 tgataagctt ttgcacttct tcagagcctt ttgcatactc gatgcctgcg taaatatctt 2631661 ctgtattttc acggaagatg accatatcag tatcttcagg gcgttttacc ggtgacggca 2631721 ctccagtaaa gtatcttaca ggtcttaagc agacgaatag gtcaagctct tgtctgagcg 2631781 ctacgttcaa agaacggata ccgccgccga caggtgtcgt taacgggcct ttaatcgcga 2631841 tgaaatattc gcggatcaca tctaatgttt cagcagggag ccactcacct gttttattat 2631901 aagccttttc tccggcgtaa acttctttcc atgtaatttt cttttcgcct ttgtatgctt 2631961 tttctactgc tgcttccaaa accttcgaag ccgcgttcca aatatcagga ccggttccgt 2632021 ctccttcgat aaatgggata atcgggttgt ttggtacgtt taatactccg ttagagactg 2632081 taattttttc accttgtgcc acaataaaaa cctcccagta tgtaattcat atttagaaaa 2632141 cattttattt ttcttatata gaaaataaaa tgatttttcc taacattcaa tttaaagtgt 2632201 aacccaattt tgatgtctga acaagaggct aacctcattg acgcaagcca gcctccaatg 2632261 gttctttagg ctctttcttc aatcggaacg aatttttgtt tgtcagggcc tgtgtaatct 2632321 gcccgcgggc ggatcagacg gttgttgtca tactgctcaa gaatatgagc gagccagccg 2632381 gacattctgc ttacagcaaa aatcggtgta aacaaatcat ggtcaatacc gaggctgtga 2632441 tatacagaag ccgaatagaa atcaacgtta ggcggaagct ttttctctga tgtgacgatg 2632501 tcttctatac gaatcgacat ctcataccat ttgctttcgc ctgtcaggtt ggtcaggcgc 2632561 ttgctcattt ctttcagatg cttcgcgcgc ggatcaccat gcttatacac acggtggccg 2632621 aatcccatga ttttttcttt cttttcaagt ttagcgcgga tgtacggctc agcgttttcc 2632681 acttcaccga tttctgtcag cattttcata acgccttcat tcgctccgcc gtgaagaggc 2632741 cctttcagcg cgccgattgc tgcagtaatg cctgaataga tgtcagaaag tgttgcgacg 2632801 cagaccctcg ctgtgaacgt tgacgcgttc agctcatggt cagcatgtaa aatcaatgct 2632861 ttgttgaagg cttcaacttc aattggtgaa ggctcttcac cgtttaatgt gtaaagaaaa 2632921 ttctccgcaa taccgtaatc ttctctcggt tcaacaggct caagaccctt gcgaattctg 2632981 gaaaacgctg caaccaggcc aggcaccttt gcctgaaggc ggatcgcctt tctgtagttg 2633041 gcttccgggt tcatggtatc agcctcgctg tcaagcaggc ctagtaatga aattgctgtc 2633101 cgaagagcag ccatgggatg aacattttcg agggaataag atttgaagtg ctcaataatt 2633161 tcttgcggaa cggcagcttc ctttgcaagc tgctgcttta actcttcaag ctcttttttg 2633221 tttggcagcc ttagatgcca aagcaagtag atgatttctt caaaacttgc attctctgtc 2633281 aaatcatcga tatcataccc cacatatgta agggtatcat caataataga actaacagat 2633341 gatgttgttg ctacaacccc ttcaagaccg cgtgtcgctg tcatatataa catctccttt 2633401 tcaataaatt tcccctttaa gagtgttgta aaaacatgag gcttacttaa aaagcacgat 2633461 gcaagtattt ctctccccca aaaagaaaat gcttacattt tactggctgc tggaactaaa 2633521 accctttgct tttgaaagaa cataacaaat ttttataagc ttatttaagt ttaagcctat 2633581 tctcattata aacaataatc agacatttgt taaatgttta cctataattt tttttttcca 2633641 ttctgtgatt tccccgaaaa aacgccttta tttgcgggtt tttgcataaa aaaaagcggc 2633701 tttaaggccg ctttttttta tgaagtgaac agttttacga tctgcatggc taaataagca 2633761 atccccgctc cgatcagcgg ccccaccgca actcctccaa aaagcgcgac tgcaagaatg 2633821 gtcccgatca cgagagcagt tgtaatatgc ggatcatttt caagcagggt caggccgttt 2633881 tttgcaatca gcgccactgc gatccccgct ccaagggcga tccatgcgta ggaagaccgc 2633941 attgcttctc caagctgctt aaatccgatt tctcccgtgg caatcgggac aagaacggcg 2634001 atggtaataa tggtcacacc ccagttaatg ccttttgact ggatggtcgg aaataatttc 2634061 tgatcaagcc caacgatttt gatgatcaaa aggacggata cagcaaagag caatgattgg 2634121 ttttttgcga taagtgcgat agccaagagt aaaattaaaa ataaattcgc ttgtgtaaac 2634181 acatgccatc cctcctttaa gatgaatgta ttcatattca gccgcagcgt gaatacatat 2634241 aaaaaatagg acatgctgac gagaggagga ccgtttttgt gaatcaatct tatatcacta 2634301 tttttttcag aaccctcttt gtcatatcaa tgaccgcagg gtcgatagct gcggcctatt 2634361 attcgtttcc gttaacttat ccgttcctga tcgcccttat tctatcttca gtgattcatc 2634421 ctgttgtcga ttatttggac aaagtgacag gattcccccg aacgataaat gttctgggcg 2634481 ttcttgcttt ttttctgctc gcagccttcg gcgtgctcac cattctggta gccgaaatcg 2634541 taacgggaac agcctatcta gcaaaaacgc tgcctccgca tatcagcacg tttatttcat 2634601 attgcgaaaa attgtttacc actcatattc agccgctcta taacgagtta actcttttgt 2634661 ttcaagaatt ggaaacgaac cagcaggctt ccatcgtcac tcatatccag acactcggtg 2634721 attctgccgc taaaaatgcc gggctcctgc tgtcccacat tctagagatg atcccgagat 2634781 ttttcgctct tcttcccaat acggcggcgg ttctgatttt ttctcttctg gcaacctttt 2634841 ttatgacaaa ggattggcat aagctgaaag ccatgcttgt tttaattctg ccggatcgtg 2634901 tgacagctaa cagcaaagca atcagcagcg aattaaaaaa agcaatgact ggttttatca 2634961 aagcacaagc cgtcctcgtt ttcatcacga tggtgattgt atttatcggc ctttctctct 2635021 taaaggttga acacgccgca acaattgctt ttttaatcgg gcttgtagat cttctccctt 2635081 acttaggtgc cggctccgta tttgtgccct ggattttgta tttatcgatt acgggccagc 2635141 tgccccaagc aatcggaatt ggtatcctgt acctcgtcgt tcttattcag cggcagctga 2635201 cagagcccaa gatactaagt aaatctatcg ggatcgatcc gctggcaaca ctcatcgccc 2635261 tgtttgccgg ctttaaatta ttcgggtttt taggactgat tgcgggaccg gctgtactcg 2635321 tcatcatcca agctttcatc acaacaggcg cattaaaaga aatatggtcc tatatcaccg 2635381 ttcagcaaaa ataaaacggc agccgttttt tcatggctgc cgttttttat ttgatgatga 2635441 tccgcttatt cttcgacatt cctctcagcc atttgaacag aatcggctta caccagccgc 2635501 gggtaaacgg gataagaaga caggcgccgg ccaaatctga taaaaagccc ggaagcatca 2635561 gcaatagacc gccaatgaaa atgcacagac cgtcagcaat cgcttctccc ggcattttgc 2635621 catattgaag atcacgctga accttataat acacttcggt tccttgtttt tttgcagctg 2635681 ctgcgccgat aatgccagtc agaatcatga atagaactgt cggcaaaata ccaatcagat 2635741 ttcctaaaaa taggaatata ccgatttcta ttgccggaaa cacaataaaa agcaaaaaca 2635801 aaaatctcat atccaagccc cccacacgtg taacacgttc tgttcaacaa aaggcatgat 2635861 aaagagaaaa ggaagggatt ccccttccat tttcacctgt aattaaagaa cgctcgcacg 2635921 gccttgatag actgcgcctc tggaagcgtc aactgtaata tcctggccat ctgtcaaaat 2635981 agatgtcgca ttttccagac ccacgataac cgggatgcca aggcttaatc cgactaccgc 2636041 agcatggcta gtcaaaccgc cttcttctgt aataagagca gacgcttttt caagggatgc 2636101 aatcatatca cggtcagtgc ttttggtaac aagtaccgca ccgtcagtca ttttttgctc 2636161 agcttctttt gcattttgtg caacgacaac cggaccgtaa gctgatttgc gtccaatgcc 2636221 ttggccttta gcgatgatat cgccgacagt atgaaccttc attaagttcg tagtgccgga 2636281 ctcaccgaca gtgccagctg taataacgat aagatcgccg tgttttacaa ttccgctgtt 2636341 caatgatttt tggacagcat cctcaagcat ctcatctgtt gagctcgcat tttggccgct 2636401 ttccgcgaat acgccagata cgagggcaag ctttctggaa atagagtcat ttacagtaac 2636461 cgcaacaatc ggagcctgcg gacggtattt tgcaatcata cgtgctgtat ggccgctttc 2636521 tgtcggcgtt acgatcgcag cagcattcag gttaatcgcc gtatgtgcga cagattgtcc 2636581 aattgcgtct gtaattgtca tgcccacttg gtctctgcgt tttgagagaa tttctttata 2636641 atttaatgct tcttcagaac gggacgcgat gttatgcatt gtttgaactg cttcaaccgg 2636701 gtaacttccg gcagcagttt caccagaaag catgatcgca tctgttccgt cgaagatcgc 2636761 gtttgcaacg tcacttgctt ccgcacgagt cggacgcggg ttgcgctgca tgctgtcaag 2636821 catttgtgtc gctgtaataa caggtttgcc cagcgcgttg cattttttga tcagttcttt 2636881 ttgcacaagc ggcacttctt cagctggaat ttccacacct aagtctccgc gtgcaaccat 2636941 taagccgtca gacacttcga gaatcgcatc gatgttgtca acgccctctt ggttttcgat 2637001 tttagggatg atttgaatat cctgagcgtt gtgctcttca agaagctcac ggatttcgag 2637061 cacatccgta gaacgtcgaa tgaaagatgg tgcgatgaag tctactcctt gctcaatacc 2637121 gaaaacgatg tctcgcgcat ccttttcagt aatccccgga agattgacac ttacgcccgg 2637181 tacgttaaca ccttttttat ttttgagtgt tccgttgttt aatacttttg ttttgatttc 2637241 gcgtttagcg gcatctacat caagtacctc aagaccgata aggccgtcat ctaacagaat 2637301 cgttgaacct tgttcaacgt catggactaa accttcatat gtcactgaaa ttttatctgt 2637361 tgttcctaca acctcgtcca ttgaaataat gagctctttg cctgtttcaa gctcaatacc 2637421 gccgttttcc attgtatgtg tgcggatttc aggacctttt gtatcaagca gaattccaac 2637481 gttcttgcca agttttttac ttgcttcgcg gatattttta attcttgcac cgtgctcctc 2637541 aaaatctccg tgagaaaagt ttaatcgagc cacgttcatt cctgactcca ttaatttcgt 2637601 aagcatttca atactttcac ttgccggacc gatggtacaa acaattttag tttttctcat 2637661 ttggttcact tccttctgaa atcttcagcc ttcagctgta cattagatag acagttcttt 2637721 tgaaagctga tacatgtttt gctcaactgt gtgttttgtc tcaagtattt ctataatatc 2637781 atggtctaca agcttattgt tttgtatacc tacacagcgt ccgccttttc cttcaagcag 2637841 cagttcaact gcatatgcgc cgagacggct tgccaacaca cggtcagcag cactcggaga 2637901 acctccgcgc tggatatggc ccaatacaga taccctagtt tcaagatttg tttcttcttc 2637961 aatgcgtttc ccgaattcaa caccgctgcc tacaccttcg gcaacaataa taatactgtg 2638021 cttcttgccg cgttcgtggc cgcgttttaa gcgggcaatg atttcgtgca tgtcatagtc 2638081 tgcctcaggg attaagatcg attctgcgcc ccctgcaaga ccggcccaca atgcgatatc 2638141 gccggcatga cggcccatta cttcgattac atatgtacgt tcatgagaag tcgctgtatc 2638201 gcgaatctta tcaattgcgt caattactgt atttaaagct gtatcgaaac cgattgtaaa 2638261 atcagtgccc ggaatgtcat tatcaattgt acccggtaca cctacacatg gaaacccgtg 2638321 ttccgttaat tttttcgcac ccatatagga accgtctcca ccgataacaa caaggccttc 2638381 aataccaagc ttcttcaagt ttgctatccc tttttcacgg ccttcaactg ttttgaattc 2638441 aggacatctc gccgtataaa gcttagtccc tccacgatgt ataatatcgc ctactgatcc 2638501 gagttcaagc ttttcaatct ttccgctgat caatcccgcg tatccgttgt aaataccgta 2638561 aacttcaacg tcatgataga tcgcttttct gactactgcg cgaactgctg cgttcattcc 2638621 cggggaatcc ccgccgctcg ttaatacccc tattcgtttc attctccatt cacctcagca 2638681 acatatatga ttaaacataa catgatcatt gccctaaaaa caatgaaaag ggatctccat 2638741 cctccctatg aaaccttacc tattatacaa ttaaataaat tgtttttaaa taaaatttaa 2638801 ggaatgtcac aaaaaataaa cgtgagccaa aggcttcacg tttatttagt ttaccccgat 2638861 atattgatct tcaaccgaga ctttgccaat tgctttatat ttttcataac gctgctgaac 2638921 taattcttct tcgctcagct tcagtaaagt ttttaacgat tgtttaaggg tttcgtccat 2638981 atagcttgcc tgcagcttca catcatggtg cgctccgcct tttacttctt taatcatatg 2639041 atctataata cctaattctt ttaaatccgg cgcagtgatt ttcattgttt ctgctgcttt 2639101 tttagcaaga ctggagtcct tccataaaag tgccgcggca ccttccggag aaataacaga 2639161 ataagtagag ttttccagca tatgcaagtg attgcctaca cccagaccaa gggctccgcc 2639221 gcttccgcct tcaccaatga cgatgcagat aacaggcact cgaaggccgg ccatctcaaa 2639281 caggtttttg gcaatagctt cactttgtcc tctttcttca gctgctcgtc cagggtatgc 2639341 ccccttcgta tcaataaaac agataattgg tctgttaaat ttgtcagcct gtttcatcag 2639401 acgaagcgct tttctgtagc cttctggatg cggcatccca aaattgcgga ctaggttttc 2639461 cttcgtgtct ttgccgcgct gatgcccgat taccgttaca gggaggccgt ggaacttcgc 2639521 aatcccgccg acaatggctt catcgtcccc gtacgctctg tctccgtgac attcaaaaaa 2639581 gtcggtaaac aggtgttcga tataatcaag agttgtcgga cggtccgcca gacgcgcgat 2639641 ttgaacccgg tcccacggct tcaaattttt gtaaatatca tcctgaagct tagcgagacg 2639701 gtcttcgagc cgttcgattt ccgcacttag atccatatcg gaatcttggg tgaatttttt 2639761 tagttcggcg attttggttt gcagttcaat caccggtttt tcaaattcta atcttggagc 2639821 cactcaatgt cacctcctgt ttgatgcata tccagcagat tttctaacgt ttttttcata 2639881 tcgtcgcgat gaataaccgc atcaagctgt ccatgtttta ataaaaactc agccgtttgg 2639941 aagtcctcag gcagtttttc tcctattgtc tgttcaataa tccgtcttcc ggcaaaaccg 2640001 atcagcgcgc caggctcagc gaaattgtaa tcgccaaggg atgcaaagct tgctgatacg 2640061 cccccggtag tcggatgcgt cattactgaa ataataagac cctgttcttc actgaacagt 2640121 tttaacgcag agcttgtctt tgccatctgc atcaaactta atacgccttc ctgcattcta 2640181 gcaccgcctg aagccgtaaa aataataaac ggaactttat cagcttttgc tttttcaatc 2640241 gcaagcgtga ttttttcacc gacgactgaa cccatgctgc ccattctgaa tgaagagtcc 2640301 atgacggcga caacagccgg gtgtccgccg atggtgccct tgcctgtcac aacagcctcg 2640361 tttaaggatg ttttctcgcg atctttttca agcttttcca gatatcccgg gaaaccaagc 2640421 ggattttccg agagcattcc ctgattaaat tcctcaaagg attgttcatc catcaagctt 2640481 tcgatacgct gttttgcgtt cattgggaaa tgataatcgc agttcatgca tacccgcata 2640541 tttttatcca actctttagt gagcatgatt tttttacact taggacattt tgtcataatg 2640601 ccttccggaa catcgtgctt cgcttgatca gacggtacgg aagcatactt tttctttttc 2640661 gtgaatatat cctttaacaa atgattacct cccttttgtg aagggttctc ttcaccgcat 2640721 gtcatcaaac agatagactt gctaataact ttaccgaaac tattgtactt tttttgtcaa 2640781 acgctgtcat cctcaattcg acaacttttt attcgatgac gtgctcggaa aggcttgtat 2640841 gaaatcagat aaggtgttga aacgacaagg ttgacagcgc attcaaaaat aatgttaaac 2640901 ccggctgaaa tttttttaag gctaaccccc taaaaaaatt tcagccgtca gtttaacttg 2640961 agaacagcgc gccggtctcc gccaacgcgc tgccattttt ggaatgaatt aaaattattc 2641021 accaataatc gtaagttttc ttgttttttc tgcgacttcc tcagggtcaa cagtgattct 2641081 tgcaacacct gtttccatcg cagcttttgc cacagccttc gcaacagcag gcgcaacacg 2641141 tttatcaaac ggtgcaggga tgacatagtc tgcgctaagc tcatcttctg aaaccagtga 2641201 agcaatggct tcaaccgctg cgattttcat ttcctcgtta atatgagtgg cacgcacatc 2641261 aagcgctccg cggaaaatac cagggaatgc aagaacattg tttacttggt tcgggaagtc 2641321 agaacggcca gttccgacaa cgcttgctcc ggcttcacgc gcatcttccg gcatgatttc 2641381 cggatttgga tttgccattg caaagataat cggatctttt gccatgcttt gaaccatttc 2641441 ttttgttaac gcgcctgcta cagagacacc gataaatacg tcagcatcaa cgataacatc 2641501 tttcagagaa ccgtctttgc gatcttggtt cgtgaacttc gccacttcat ttttgacatc 2641561 gttcatgccg ttcgggcgcc cttcataaat ggcccctttg gaatcgcaca tcacaatgtc 2641621 gcgaacgcca taatgatgaa gaagcttgat aatcgcaatg ccagccgcac ccgcgccgtt 2641681 tgcgacaact ttaatggatg acatggattt tccagacagt ttcagcgcgt tcacaagacc 2641741 tgctacggtt acaatggcag taccgtgctg atcatcatgg aaaaccggga tgtttgtttc 2641801 ttttttgagg cgctcttcaa tgataaagca gtttggcgct gcaatatctt caaggttgac 2641861 gccgccaaat gtcggttcca gcaattttac agtttcaacg attttatcaa catcgtttgt 2641921 gtttaaagca atcgggaacg catctacgcc cgcaaagctt ttgaaaagaa ctgctttccc 2641981 ttccataaca ggaagcgccg cttcagggcc gatgtttcca aggccaagca cagctgtacc 2642041 gtcagttaca actgctacca tgttcccctt cattgtataa tcatatactt tgttaatgtc 2642101 ttcatgaata tccttacacg gttctgcaac acccggagaa tacgcgaggc ttaaatcttt 2642161 cgcatttctg acctctactt ttgatttaga ctccagtttc ccctggttga ctttatgcag 2642221 gtgtaatgct tcttctctta atgacattct cctaaacact ccttatggat attttttgat 2642281 tcgtatactg ctgcgttgat tgctgcattc tgcggagtaa atctatctga atatttaaac 2642341 aggatcacat aattgctcca attgtataac aaaaagcgaa tcgttaccac tgttttaaaa 2642401 cgacgttttt ttgacccaac agctctttta agcgatataa cacctggtga tctgcattga 2642461 tatggaacga ctcaggtagc ttaatcgtct gtttttgcct ttcataatag agataaacgc 2642521 ctgtttcccc tttatgctcc agcaaaatgc gcttaatctt tgccaggatc tcctggctgt 2642581 gctgactgct ttctattttt atataaaccg atggcgcttt ttctgcatcc atatcttcta 2642641 ataattctgc ccgggacatg atgaattgga tcttatcttg tctaacttca catttccccg 2642701 cagtgaacaa aagagcgcct tctcttaaaa cgggagaaag ctgtctgaat tgttcaggga 2642761 agactacggc ttccatctcg ccggtttcat cactgagcgt taaaaacgcc atgttttgac 2642821 ctgttttcgt ccgaatcgtt ttgatcttcg acagcagaac gcctagtgaa agctgccttt 2642881 tgactgcccg ctgagcctgc agaatggaga ctgctccttg cgcagtgagc tgttttcgga 2642941 aggcggagag gggatgattt gaaaaataaa tgccaagcgt ttccttttca aacgcaagta 2643001 aatccaccag aggaagctcc tccgtctcca catacttcgg cttaattgaa aacgattcat 2643061 ctaaaaacaa tcccatttgg tcatcgtccg cggcgaatag ctcagcatgt tccaaagcaa 2643121 catcaatgga tgcgagcagc gtggcccggt tttggccgaa ttcgtccatc gcaccagaaa 2643181 agataagtgc ttcaagcatt ttgcgattta cgctttttga cggcacgcga aagcagaaat 2643241 cgaaaagatc ttcaaatggt ttctcttttc ttgctttata tatatctttg actgctgaga 2643301 cgcctacact ttttatcgcg cggaggctgt atctgacaga tccgttttca actgtaaacg 2643361 gaaaactgct tttattcact gacggaggaa ggatacgaat cccgctcccc tttgcttcgt 2643421 aaagatattg agagatttta tcctcattgc caatgacgct tgtcagcaat ccgcacataa 2643481 aatataacgg ataatgagct ttcaaatacg caagctggca cccgatcatg ctgtatgcca 2643541 ccgcatggct tctgttaaag ccatagtttg cgaatttgac gattaaatcg tagacctcat 2643601 ttgcagtgtc tacagaatac tcctttttta agcacccttc aacaaaatgg cttcgctctc 2643661 tgtccaggat ttcttttttc tttttgctga ccgcccttct caataggtcc gcttcgccta 2643721 aagaaaaccc cgccatacgg gaagcaatca tcataatttg ttcctgatac acaatgacgc 2643781 catatgtatc ttccaaaatg ctccttaaat cttcatgagg atagtgaaca ggcgcccgac 2643841 cgtgtttacg gtcgataaat aacggaatat tttccatcgg acccggccgg tacagtgcat 2643901 tgaccgccac aatatcttct aggcccgaag gtttcagccg tttcaagacg cttctcatcc 2643961 ctgcagattc aagctggaaa atgcctgtcg tatccccttt tgacagcaag gagaacgttt 2644021 tgtcatcgct gtaggaaata cttgaaaggt ctattttaat attttcttct ttttcaatca 2644081 ttgaagtgat ggattcaata agtgtcagat tcctcaaacc taagaaatcc atttttaaaa 2644141 ggcccaagtc ttcaagatgg tccatcgcgt attgcgttaa atagatccct tcatgccctt 2644201 cttgaagcgg aacaacatct gttaacggtt cttcactcag gacaacgccc gctgcgtggg 2644261 ttgatgcatg ccttggcagc ccttctattt tccgggcaat tgaatagact tgctgaagca 2644321 ggcttgactc ccgaagccgc ttatccagct gcggtgactg ctgtctcgct tcatccagcg 2644381 tcattcccgg tcttgaagga atgagttttg caagctgatc tgcctccttc gggctgacgc 2644441 cgaatactct gccgacgtcc cggagcgccg cctttgccgc aagtgttcca aaggtgataa 2644501 tctgtgcgac gtgcattgca ccgtatttct gctgaacata ttgaatgact tcatcccttc 2644561 tagtatcggg aaagtcaata tcaatatccg gcatgctgac gcgttcggga tttaaaaatc 2644621 tttcaaacag aaggtgatgc ttaatcgggt caacatctgt gatatacagc acatatgcca 2644681 caagagaacc cgccgcagaa ccccttcccg gtcctgtaac aatccctttt tcatgggcgt 2644741 gcttcataaa atcccacacg atcagaaagt aatcgctgaa cttcatccgc ttgatgacat 2644801 caagctcata ttgaagacgg cgaaggtatc gttcatcagg cttgccgaaa cggctgcgga 2644861 gtccctccat acagatatcc gttaaataat catcagcgga cgttccgtct ggggtcggaa 2644921 aagacggtag acgggtctgc ccgagactga cgtcaacccg gcattgttcc gcgatctcta 2644981 cagaagcttg cagtgcctcg ggatgctctc gataaatgtt ttgcatttct tcgagtggtt 2645041 tcaaatcgag atcaggcaaa tcttcagcgg gtgcatccgt cagtttttcc cccgctttaa 2645101 tcgctttcaa acaacggtag gcagccttat cttccttcct tatgtaatgc acatcgcctg 2645161 tggccgtaac agggataccc gtttcttctg acagctttag aatctgctca gacaagactt 2645221 gattcccttt aaaaggctga taggagaaat aaaaagctcc ctttccgaat atagactgaa 2645281 attccagcga ggcttgagca gcctgttcga acagccctcc ttcaagaagc gtttcaatat 2645341 atcctttttc gccgggcgtt attgcgataa tcccttctcg ataactgtga agccatttcg 2645401 gcttcagtcc gccttttgat ttagattgca gaacgctgct gattttcagc aggttttgat 2645461 agcctgtatt cgattttgcc agcaggacga gcgggtatgc ttcaagctcg ctgtcatctg 2645521 taaaaacaga agccgtcaaa ccgattattg ggttgatccc tctcgccttg caagctttat 2645581 aaaattgaat agctccgtac atgacatgat catctgtcag cgccaaagac gcatatccga 2645641 gcctgtcagc ttcactgacg agttcttcca cagccgcggc gctgtttagc aggctatacc 2645701 cgctatgcac ttgcaggtga acaaaagaca tgctatcacc tctttctcat tacgatccat 2645761 ttcttccttc attataaggc cggtttccaa aagaaacaaa tgttcttttt tgactcatca 2645821 tcatacttgt cctgaaagct caatatgata taaaaggtga ggtgataaag atggatcagg 2645881 aagcaggatt tatggtgaat tttatcaata gctacttcat tgcgttaggg gtgctgatcg 2645941 ggggcgcact catcggaggg ctcggagcat acttggcagg cgaacccccg cttacagcca 2646001 ttacaaagct tgccaaccgg ttaaaaatat gggcgcttgt cgcagctatc ggaggcacct 2646061 ttgatgcggt atacagcttt gaacgcggca tactcgaagg caatacgaga gatatcttta 2646121 aacagcttct tttaattatt tcggccatgg ggggcgcgca aagcggctgg cttattatat 2646181 catggctgac ccaggagcat ctttcttcat gagggtcccc cagcattaca aaaaaccggg 2646241 atggcagcgt tttttcgcgg gaatgatgtg cggagccgta atcagctggt tctttttcct 2646301 gtttacttac ggaacattcc aagaggagca ggtcagcctc atcgaaaagc aaaaagagca 2646361 tgtaaaagac ttgaacaatc aaatttcgat ctatcaggaa gacctccata aactgaatga 2646421 agataataaa agaaaactgc tgattcaaag cgtcagcgtc aaattgctga atggggataa 2646481 atataaaata tcacagccgg ataaaacgaa attcgaggag catgtaaagg atgatatttc 2646541 agaggtgatt acaaaagaca tagagagcgt ctatcaaaca aaggatctct tgaagcggac 2646601 aattgaaaat aaagtctata tgatcaatga aaaaaaatac gaggcaaccg tcagagaatt 2646661 gattatttat acgaggctga cagtggaact tgaaatttct ttcgccacat aattatggat 2646721 tttttttaaa ttctccaaac ttctgtcgct ttttcccatt cttttttata aactatatgt 2646781 gaggcttaat ggcgaaagga aggaggaagg gaaatggagg tttacagtga ccgtcagtta 2646841 gcaaaagatc aagcagcccg tctcagacaa ggtttttctg catatgccga aacaaactca 2646901 ctcgcttccc tcatcaaaaa agaacttcaa tcacacaatc tccaagtcta cgaggacctt 2646961 actgatttcg gctgctggtt catccccgtc acagatgaac actaagagag agggtctccc 2647021 ctctactcgt gttctttaca taatgtttcc agatcagcta aaatacgatc agcttcatcc 2647081 cagctgtaaa tagaggcgcc tgaagctaac ggatgccctc cgccgttata tttccgggca 2647141 agtccgttaa tgacaggccc cttcgaacgg aatctgactc tgatttgatc gtcttcttct 2647201 acgaaaaaca cccaggcgcg aatacctgag atattgccaa gcgtcccgac aagctgcgac 2647261 gcttcagaag ccgttgtgcc gaatttttca agcgtatcct ttttgatgaa aacagaagcc 2647321 gccccgtttt cggacaaaga cacattttga aagataaagc cgttaagctt caccacattc 2647381 agttttgttt catacaattg attaaataac tctgaggaag agaatggata ctgaatgagc 2647441 tcgcctgcat attttagtgt tttttccgtg gtattcggaa ataaaaagcg tccggtatct 2647501 ccaacaatgc cggcgtagat cagctctgcc gctttcgtat tcagcttcca gccgtgctct 2647561 tttccttcta aatacagctc gtaaatcatt tcacttactg agctggcgct tgtatcgacc 2647621 cagagaaggt caccgtatgg atcttcgttc ggatggtggt cgattttcat tagtttggcg 2647681 cctgaaggat aacgctgatc gtcgattctt tcctgatttg ccgtatcgca gacaatgaca 2647741 agtgcgcctt catatgtttc attgtccacc tcatcaaggg aatataagaa agagagggac 2647801 ggttcaggcg tgccgaccgc aaaaatattt ttttcaggat atgtttcacg caggatttcc 2647861 gtaagcccac actgtgatcc gtaggcatcc ggatcaggac gcacatgtct atgtaagata 2647921 atcgtgtcat ataatgatat ggttctgatc aattctgttt tcatttgata ctcctttatt 2647981 gtttttattc attaaatcac attctctgcc gacggaaaag aaaaataacg tcaaaaccaa 2648041 gcccgttttt gtataaaatg gggttgtaaa cttttacgat ggaggatttc atttatgctg 2648101 gttcttgttt ttttgattgg gctttcagcc tgcttttatg tgtactataa agtaaaaggc 2648161 gtacgggcaa agccatcttt ggcaaaagaa atatgttcag caaaatcaag catggcctta 2648221 gggtcactag tcctgttcta cgggcttaac caaatgatat tattccattc agtattaacg 2648281 ttagtaatcg gcggtatctt tatcgtcata ggagcaggaa gcgcttgggc aggttataaa 2648341 gccttcaggc attacaatcc ccttcacgcc aaagaagctg aaagagatca cgcgtaaggg 2648401 gcgcctgaac gtcccttagc ttctttccat cagctgaacc atcagcatcg ctttagacac 2648461 gatatgacct tggctgtgca cttccacttc cattttccca aactttctgc cggcctccaa 2648521 gatgcgaggt ttgacttcga tgactgattc catctgcaca ggcttcaaaa agaagatggt 2648581 gatgctctct atgacgagtt cgccgcgttt tttcgagcgc aaaaatcggt ttgccgcttg 2648641 cgtcaaaatg gtcgtaaata cgccataaga aatggttcca agctgatttg tcatttgcgg 2648701 cgtgacttca tactcgtaaa ccgtttgatc ttctttatca tcaccctcat ctttaaaccc 2648761 ccttgaaacg atatcatcaa gcttctcccc gacctgcggc tgcttttgaa tcatttgaag 2648821 agctttcaat acgtcttggc ggctgatcat gccgatgagt ttttggtggc cgtcagtgac 2648881 gggaagcact tcgatccctt cccataccat catttgcgca gctgaagcga cagatgtttt 2648941 cccaataacc gtgacgggat ttttggtcat gactttttct atagatgcat ttcggtcatg 2649001 gccagcaata tcttttgatg tcagaatgcc atggattttc atttgatcgt cgacaaccgg 2649061 gaagcggccg tgccccgttt caaaattttt ctcataccat ttttcaagtt tatccttagg 2649121 cgaaagatat accgtgcggt cagcaggtgt taggatgtcc tccaccaaaa caatttcttt 2649181 tttgatcagc tggtcatata ttgcccggtt aatcatcgcg gcaactgtaa aggtgtcata 2649241 gctcgtggat aaaatcggca gttcaagctc atctgccagc tgcacaatgc tgtcatccgt 2649301 gttaaagccc ccggtcacca atacggccgc gcccgcttca agcgcctgcc tgtgtgcatt 2649361 gattctgttt ccgacaatca aaagattccc cgctgcggtg taacgcatca tcgcgtcaag 2649421 ctccatcgcg ccgatgacga atttattcaa tgtcttatgg agccctgccc tgcctccgag 2649481 cacttgtccg tctataacat ttacaacctc tgcataggta agcttttcaa tgttctcttt 2649541 tttcttttgt tcaattctga ttgtgcccac acgttcaatc gtgctgacaa accctttatt 2649601 ctctgcttcc ttgatcgctc tgtacgcggt tccttcgctt actttcattt cctttgcaat 2649661 tcttcggaca gaaatttttt caccgacagg cagtgaatcg atatacgtta aaatttgttc 2649721 atgcttcgtt gccaagcctt tcacctctaa ggacagtctt cttgttttta ttataaggtt 2649781 tcaaaggatt tatacgcaat gaggctggaa aataaaaaag aagcccgacc ggcttcttac 2649841 agcgttgatt tcgttccagt caaacgcaag gaccacgtga ttccttttac atcgtaaagc 2649901 ggaaaaacct ttatttttct tttaaatgga catcaaccgc tgtcttaaca atatttcgat 2649961 tccctatttt agataaaaca aataaaactg cggatagcca tatcgcccct atggccgtat 2650021 agatcaatgg atgaacagct gtgtttgcga tccattcatt tattaatgtt ctggcattta 2650081 ccagaataat aaatcctcct acaagcacac ccatcaattg cggatgaaac ttctgcacca 2650141 gccatgctgc gataggggca gcgataattc cgccggccat tagtgaaaac acccataacc 2650201 aattgacgtc ctcccatcct aatgaaataa gaaaaccggc ggttgcagat acggcgatgg 2650261 caaattcact tgtgtctaca gtcccgacaa ctttcctcgg gctcaagcct ttgcgggata 2650321 ataaaatcgg agtggtcacc ggtccccagc cgcctccgcc tgtggcatct gcaaaaccag 2650381 cgatcactcc caatgggatg gattgttttc ggtttaacgg cacatgcttc ttctcaagag 2650441 ccggcttata ttgaaataaa aacctgatca atacatatcc gcccagaagg agcaaaaaca 2650501 aagaaatata gggtttcgcc acatctccag gtaattggct gaggaatgcc gcgcctaaaa 2650561 aagcgcctat agagccggga atgacaagct gataaacggt ttgtttgtca acattgccaa 2650621 atttaatatg cgacactccc gatgcggcag tcgttacgac ttccgctaaa tggacagaag 2650681 ccgaagccac agcaggtgtg atgccaaacg ccaataacaa agaagttgag gtaaccccat 2650741 aagccatacc taacgaaccg tctattaact gcgacaataa accaataaat gcaaaaacga 2650801 ttaatttctt catcagaaca ccccatctat atcaatcaga tatttttgac tcttcattcg 2650861 aatctaacaa tctcttggcg ctttcatata aaaaataaga ggctttgata attgcagttt 2650921 catctattgt aaatgcaggg tggtgccaat catgatcacc gtctgttcca aaaaacgcaa 2650981 aggatcccgg aatatgctca agataataag caaaatcttc ccccgcggtt gatggggcgg 2651041 gatcaatgac ttgaagtttc gctttatgtg cagcgtctcg caccagcccc gtaattgcct 2651101 catcattaca aagcggcggc ggtccggaat gccacttcac atttgccttt aacgagaaag 2651161 cggcagaaat ctgctctgtg actgcaaaaa aacgctgttt cacttgatta cgaacctctg 2651221 aatcaaatgt acgaacagtg ccctcaatga ccactgtatc cggaatgaca ttccaagtgc 2651281 tgccgccgtt gattttccct acggttaaaa tcgcgctttg cagcgggttt acatttctgc 2651341 ttacaatcgt ttgcagggcg acaataagct gagaggcgcc gataattgga tcaaaaccat 2651401 tatgcggcaa tgctgcatga gcacctttcc cttctatctc tactttaaat cggtcaacag 2651461 cagccataag cgggcctgtt tttaacccta cagtcccaac cgcgatatcc ggtttattgt 2651521 gaaggccaat aaccgcatca atgccatcca gttggccgtc ctctatcact tttgtagcgc 2651581 ctgcacccgc ttcctctgct ggctgaaata ataaacgaat ctttcctttc agactgtctt 2651641 gattttcctt caataaaaag gccgcaccaa gaagcgctgc cgtatgaaaa tcatgaccgc 2651701 acgcatgcat gatcccttta tgtttagacg cataaggcaa tcctgttttt tcttcaattg 2651761 gcaaggcgtc aatatcagcc ctcaaagcaa tcgccggacc ttctgactcc cctgctatgt 2651821 ctgcgaacac acccgttttt agagcagtag ggcgaatctg tatccccttt tctttaaggc 2651881 atttttttat aaaagcagtt gtttcaaatt cttcttttga cagttcagga tattggtgca 2651941 ggtgccggcg aatgccgatg agctgctttt ctagcgttga gagatttacg ggattagact 2652001 cctctttcaa cgtcaggatg tcatttcctg tagtctgata tggataggag ccttctatat 2652061 ttctccaata atccaaagac atatgttccg ctcctttccc tatcccaata tattttcttc 2652121 agactcttca acataagatg aaataaatcg gttcaattta tcagcaagac cgcccgcccc 2652181 aaatcttata tacttgctgg aaactttcgg attatcttct ttcaaaaagc ttaaaaaaga 2652241 taaaatataa atgcgcctgt aagctacttg tgtaattccg tactcaaaaa accagttatc 2652301 aatgacattg tatacgcctc ggttgacgcc atataggtta ttacatttct tgtaaaagca 2652361 gagatccgga agatttaact cctgatggga aagaaggctt tcttttttgt ttggtgccat 2652421 aatcccaatc agctcaaagc gttttgcaac gcacgaaata tcctttttaa tttgctttgt 2652481 taaagactcc aaagaatcaa accttctttc ttctctaatt ttaaagagaa tgctgcattc 2652541 gattttttct ccataaatgt ctctatgaaa gtcaaacaaa aaaatctcca atgtcttttc 2652601 aaggttagag cccaccgtcg gtttcacacc gatattcata acccctaaat gaaattgatg 2652661 attgactgtc gccagaaccc cataaactcc attacgcagc ccatgtattt ttgcatctac 2652721 atttgccgtg gggaatccaa gctttctgcc taattgtttt cctttcacaa ccgtaccggc 2652781 aatgatcgtc aaaaaagtca gcctcctctc tcagcttccg cattcgatca gacgaaacct 2652841 aatgatgtga tgaatgtaaa acggattgat gctgcggaat gccaagaccg agattttccc 2652901 gcaatgtccc gccgcgataa tcttgacgat aaagccctct ttcttgaaga atcggaatca 2652961 ccttttctac aaaagcatca agtgttcccg gtatatccga cccaacgata aacccatccg 2653021 ccgcctcagc gttgaaccaa gtttcaatta aggatgcgac acgctctggt gttccgatga 2653081 atagagtccg tggaaaagcc atttcctgtg ctacctcccg caatgtcaga tttctggctt 2653141 ttgcttctct cttaatccgg tctgttgtgc tttgaaacgc attctttccc acatcgccaa 2653201 tatcgggaaa tggctcatcc aacgggtaaa cactcagatc ataatcatca aaaaaacggg 2653261 ccaaataagt aacagcattt tcaatcggta tcaattctgc aaattcacga tacttctttt 2653321 ccgcctcttc ttccgtatct gccacaatcg ggctgatccc tggaaaaatc cgcacacttg 2653381 aaggatcacg cccttcatca gcagctcggc ttttcacatc cgcataaaac gcttttgtct 2653441 cttctaatga attggaatgg gtaaaaatcg catccgcatt tttagcagca aactgccggc 2653501 ctgtttctga tgaacccgct tgaaacacta caggctctcc ctgcttagag cgcccgatat 2653561 tcaagggccc ctctacttga aaatactttc ctttatgatt caggcgatga agcttcgcct 2653621 gatcgaaaaa ctgccctgtt ttcttattgt gtataaatgc gtcatgctcc caggaattcc 2653681 acagcccgcg cacaacatcc aaatgctctt gtgcgatctc gtaacgttca gtgtgttctg 2653741 gcaaattaga cttactatgg ttgcgcgccg ctccttcctg cggcgaagta accagattcc 2653801 agccggccct gcccccgctg atatggtcca gcgacatcaa ttgtctggag atagtgaatg 2653861 gctcagtaaa agatgtagag aacgtcccta ctaaaccaat atttttggta accgatgcca 2653921 gcgcagataa aatggtgatc ggttcaaaac ggtttaaaaa atgaggaatc gatttttcag 2653981 aaataaataa gccgtctgca atgaaaataa aactaaacaa acctttttca gctgtttgcg 2654041 cctttttcat gtaaaattca atattcgtgc tggccgaggg atcaacatcg ggatgacgcc 2654101 agccgtcagt tgttcccccg acaccgtgaa tcatggctcc aaactgaata aaatctgcac 2654161 gtgtcatctt tttgcctcct ttatctgtgc atgattagca agtgcaagat caaggtgttc 2654221 aatgccgatt tcagttatcc cttgatactg attgccgcgc ccgatttcga ccacaggcac 2654281 atggcgcacc ccatatttca cctgtaaaat atcccgaagc ttttctttct ctgaaacatc 2654341 gatattttgg aacgggaacc ctttttcatt caaataattc ttgacttcct cacaatacga 2654401 acagcctttt ttactccaaa ccacaatgtt cacaacatca ctcattcttc tgtccctcct 2654461 taacgttttg cagctaaaac tgcatcgctc agcagctgat aagacagctg tttttctaca 2654521 gcatttttga tcggtgtaaa aataacaaaa tcattgattt tgtatgtgcc tgataaacgt 2654581 gttaattctt ctgccacttc ttcctttgtt ccggcaataa tcccggtttt ttgcacgatg 2654641 atgtcatagg gctctgtgac gttttccaga taggcctcag cctgttcgcg ggaaccgacg 2654701 ttgaccttac gcccgtcttt caaaaccact tttatcgatt cacgcgacac aatatgtttt 2654761 tccgcttctt cttttgtatg tgccgcaaaa acagcggggg caagatgaaa ttcagcctca 2654821 gatcctggcg ggagatgcgc gtcaaatgct cggcgggctt ccttcagcac ttcctcttca 2654881 ccgttaataa agtaagcaaa gacaaaagag attcccagtt ttgcagcaga aatggcactc 2654941 tctgtgcttc ctcccaatag aaaaataccc ggcttccgat caacctgcgg cctaggacgc 2655001 aatgcggcat agcggtgggt atcaggaaaa tcatcccgaa cgaaatgagt aagctcctcc 2655061 agtttttcat caaactgacg caccggtttt ttatattcgg cctgcagcgc gtctgtggac 2655121 agctgaaacc cgccgggcgc tttgcccact ccaagatcta tacggccggg agctaacgct 2655181 gatagaagat ggaattgctc cgctacttta taagagctgt aatgctgcag catcactccg 2655241 cctgatgcta aacgaatttt tcttgtgctt gcagcaagat agcctaaaag aacctcgggt 2655301 gcagaccctg caatctcatc attgttgtga tgttcggcca cccaaaatcg gtgatatcca 2655361 cattcttcag ccatttgtgc caatttcact gtatgctgta atgtatcagc tgctgtctcc 2655421 ccttcaccaa tcaagctttg gtctaaaata cttaagcgga tcatatcacc ggctccttta 2655481 tgtgttcttt tggttcaaat aaatattccg gcgaaacacg gcggagaaac tgcctcgttc 2655541 tgtctttttt ggtatggcgg aagacttcct ccggggttcc ttgttcaaca atgactcctt 2655601 catccataaa aacaacttga tcagagaccc ttcttgcaaa ctccatttca tgtgtaacaa 2655661 caatcatggt ggctccggtt ttcacgattt ccagcattac ctcaagcact tcaccgacca 2655721 gctccgggtc aagcgctgcc gtcggctcat cgaacagcag cacatcagga tgaatggcaa 2655781 gcgcccttgc tatccctacc ctctgctttt gtcctcccga taactgactc ggataagcgt 2655841 tcaatttatc ttgaagcccg acctttctca gttcattttc cgctacggca tacgcgtctt 2655901 gttttctcat tttccgggca atcgtcaagc cctccatgac attttcaatc accgttttgt 2655961 gagcaaacag gtggtattgc tgaaatacca ttgccgtctg ttttctgagc cagtgaacct 2656021 cttttttgga cggaaagcgg caattaatca ctttgtcatg tatagaaatg atcccttcgt 2656081 ctggacgttc taataaattc aggcaccgta aaaaggtggt tttccctgat ccgctcggcc 2656141 cgataatcgt cacaacttct cccttgcgta ccgtgagatt tatccctttt aatacatggt 2656201 ggatgccaaa ctgtttatgg atatttttaa tctcaatcat aaagtgcctc cttgaaatct 2656261 ggctgccttt ctctctaata ctccatttgc ggattctagg attagagtca gcacccaata 2656321 gataatcgct gctccgataa acgcttctaa aaatgcataa ttatcagaag caacgatagt 2656381 cgccgtccct gtaatctctg ggacagccac tatagccgcg atagaggtgg tatgcaaaaa 2656441 gccgataccc aaatttgtga agtttgggat ggaaaccttc agcgcctgcg gcaatattac 2656501 acgccgaaag gtttggctgt atgtcaagcc gattgaataa gccgcttcga cctgtccggt 2656561 atccatcgcc agaatgcccg accggatgat ttctgtgaga taagctccgg cagttaaaga 2656621 caaggccatg atgacaaaca tggagaccgg tatctcatta gcggaccagc cgagatgaaa 2656681 aaaactgctg acttgatctg caacaggcgg tatccctaaa taaatcaaca taatgtgaag 2656741 aattgcaggt gtacttcgaa agaaagacac ataaaacctt gagcaagcca ccaagccctt 2656801 aattctaaaa attctaacaa ttatatttcc aagagccacg agaaatccaa acacaatcgg 2656861 caaaacagcc atcatcaatg tcagaggaat ggtctttacc atttctttca tggcggaaac 2656921 gataaatgga aagtcaaatt gcaatcttct cccccctcat ccgaagaaat atatcaatgt 2656981 atgttcatgt caaaaacagt aacaatcctt gtttgattct tcttgattcg tttttctgcc 2657041 actcgaaaga accattcgaa taaaaccgct acagcataat aaacaatcga tagcgcaatg 2657101 taaacttcaa gagaatggtt gcttgaggta atcagtgttt ggccccttcc ggacatatcc 2657161 ataacaccta ttgaaaaggc tagagacgta tcttttaaag aactgatcac catgtttccc 2657221 atattcggaa acgcctggac aagtgcctgg ggcagaacga ttcgcctgaa ggcctgacta 2657281 ccgcttaagc caatactgta cgccgcttcc gtttggcctt tatctacact gcccaccccc 2657341 gctcgaatga tttctgcggc tgccgctgca ttgcttaacg cgtaggttgc gacagcagca 2657401 taaaacgggt ccatttttga tgtatcaatc ccgataagcc ccgtaagcgc cgggatcccg 2657461 taaaacacga tgaaaagctg caccatgata ggcgttcccc tgaaaaacga gatatacact 2657521 tttgccaatt gatttacaat tggaatatta tagatgcggg gcagtgccag aaagagtcct 2657581 aatacaaaac cgaaaagcaa ggacagtgtt aaaatgtata atgtaaccgg taaataagcg 2657641 gttaacgtcg gcacaaaatc tccaatcatg ttcatatcaa acgctttttc catcactgct 2657701 ccctctcttt ttacctaata ctgctctttg gaatagtcgt caccaagcca tttcaaactg 2657761 agccttttca acgttccgtc atcaatgatt tcctgtaagg ctttatcaat atcgtcactt 2657821 aacgtttgtt catttttgtt aaacataaaa tacactttgg catttgaaag cacattaccg 2657881 acggtttttt ctttaatagt gctcgtcttg ttttgaaagt ctactgcaaa aggcgttgag 2657941 atcgttgcgt ccgcacgccc cgatttcagc tgattcgcag tctcatttgc gccttggccc 2658001 tcataggcaa tctcaaacgg ccgtccatta tcctcattcc attttttcag tacaagcgct 2658061 ccgttggagg ttgcactcgt aatcacccgt tttcctttta agtcttcaat tccacggatc 2658121 gtatcgttat tttgaagcac agtaattttt aaaggaaaat ggttgtaagc aaccttgtta 2658181 aacagaaatt ttttctcacg ctctttgctt ttctccattt gatgtgccac gatatcgact 2658241 ttatgctgtc cgaggctgac aagcaggttg gaaaattcca tcgttttaaa tgtgaattta 2658301 taatgtggca ggcgcttatc aagctctttg atcagttcga catcataacc ggttaaatcg 2658361 cctttttcat cgataaagca aatattcgga aattgggttc cagttccgac cgtgatcgtc 2658421 tgtaccttct tttgcccggc tcccgtcgtt tgactgcctg caccgcaagc tgacagaact 2658481 gttataagcg aaaataatat tgccatgaat gctgttttcg ttttcatctc atcgccccat 2658541 ttatttttca aaacttgatt ttgaataatc tgccccgagc cattttcggc ttagtttttt 2658601 tagcgttccg tttttctcca gctttttaat cgcttgatcc gtgtcatccg ccaaggtttg 2658661 gctgccttta ttaaacataa agtacacctc ggtatctaat aacacgtcac cgactgtctt 2658721 ttggcggaag gcgtgcgttt tattctgaaa atcgacggca aacggtgtag ctatcgttgc 2658781 atctgcgcgc ccggtttcaa tttgattggc ggtatcattg cttccctgtc ccgcatattt 2658841 caaatgaatt gggctgccgt gcgttttgtt gtactttgta atataatctg ccgcatttga 2658901 cgtggcgcca actatgactg tttttccgtg taagtctttt aatgtatgaa tcttgtgatt 2658961 atcctctttc accgtgatgt acatcggcga gtagttatat gggactttat gatacaaaaa 2659021 acgcttttct cgttctttat ttttggccat attgtgcgca atcacatcaa tttttttatt 2659081 tccgagactc gtcagcaaat ttgagaaatc catcgtttta aattcaaatg tatattgagg 2659141 caactcctta tcgatggctt tcatcacttc aatgtcatac ccggtcaatt cacctttttc 2659201 atttaaaaac gcaatattcg gaaaatctgt tccagtgccg actatgaccg tttgagcctg 2659261 acgatctgtt ttgttatttg tttgcgaaca tcccccgcca agtaatgcaa acactgacag 2659321 cagcaaaacc aatcctttac gcttattcat aggctgcctc acatcatgcc cagctgggcg 2659381 cacctaaaag cgttgggtta aatcgttccg gaatcagaac cttgtgcatc atcacaccta 2659441 tgtccccgtc tttttcctgc tcaaaataca cttcataccc tctccttctg tacatgtcag 2659501 caagccaagg atgcttgcgc gccgatgtgc cgagtgtcag cgcaggagcc ttcagcatat 2659561 ctcgaagcac tttttcttca acatacgtaa gcagcttact tccggcgcct tgccctttat 2659621 attccggcag tgtcgcaaac caccacacaa atggatattt tgaaggaggc gtctcactct 2659681 cccacgggaa cctgattgta atcgttgaaa tcagcttccc atcccgctcc agcacaatcg 2659741 ctgaatgatg ttcaatattt tctgatacca tttggatatc agctctcgtg gatggccaat 2659801 caatatccag ctgccgaatg ggctgaaatg cgctgttaac cagtttcaac agctccgatg 2659861 catcttcaac agttgccagt cgaaaaatat catcactcat ttttgtcact cctcttcaca 2659921 aaatatataa ttcctatttg tttactaagc ttttattgtt tatactataa agcatactct 2659981 gatctttgac taatcaaaaa aagtaaacct tcacttcagt aattttaatg atgaaaaaca 2660041 ggagggagca cattggagtt acgctcaatc aaaacgtttc atacgattgt aaaatttgga 2660101 agcttctata aagctgcaga aatactcaac tactcgcagc cgacgatatc gatgcgtatg 2660161 aagcaattgg agcaggattt aggcgtactg ctgtttgaaa gaggaaaaag cctgcagttg 2660221 acaaaagcag ggaagctttt ttatgaacga acaggagatc ttttgatgca atacgaggcg 2660281 cttaaacaca acctctccga cttaaaggaa gaagaggcag gcattatcaa cataggggtt 2660341 tcagagccaa ccgccagtct gatattcccc gagattttaa aggatttctt aatggattac 2660401 ccaaagataa cggttaatat caaggttgat gacgccaata cctgcagtca aaagctctta 2660461 gacgggacga ttgattttgc agtctgcggc gagccggagc tgattcttga aaattactac 2660521 catccatttt tttatgacac attaaatgtg attgtatctg atcaacatcc gctcgctgag 2660581 aagaaggctg tccatttgtc tgatttagca gaagagcgct tcatatttac gcccgccaat 2660641 tgccccattc gcttacaaat tgaacagcat ttacatagag aactcgggaa tcgctacaaa 2660701 aaaatggagc tcacaagcag catgtcacat gaatattacg tacgtgaaaa catcggaatt 2660761 tcaatcttta ccagcaccgc acattctaaa ccgttcaacg gcactaaagt cattccaatt 2660821 ctgaacctgg atatcacccc gcccataggg ctgttgacaa atcaaaaaga agttcatttt 2660881 gaccgcgcca cgaaggactt gatcgcccgg ataaccaaac gttttcagca gcgcagcaaa 2660941 gaattggaag gaacctctga taagaccatt acaggataac tgaaaaaata aaaaccacct 2661001 cctgattcat caggagatgg tttcacggtt taaagctcga tcgtctcacc gaccgacatg 2661061 actttgccga ctccgcccgg caggctgtca gcgaatgctt ctgggtcttg ttcgatgacc 2661121 gggaatgtat tgtaatgcac cggcacgacc tgttttgcgc gcagccattc agcagcaagc 2661181 ttggcgtctt caggccccat tgtaaagtta tcgccaatcg gaaggaaagc aaggtcgata 2661241 tgattcaatt cgccaatgag tttcatatca gagaaaagtg ccgtatcgcc cgcgtggaaa 2661301 atcgttttat cttctacagt cagcaaaata ccggcaggca tgcctgtgta agtgatcgtt 2661361 ttgttttctt catctgtgat ggctgatcca tgaaaggcct gtgtgagctt cacttttcca 2661421 aaatcgaact ggcgggagcc gccaatatgc attggatgaa cattcaagcc tttccagcct 2661481 aagtacacag cgagctcgtt cggggctata accagcgcgt tattttgctt ggcgatttgt 2661541 tcagtatcac cgacatggtc attgtggccg tgcgttagta agatgacatc cgcttttaca 2661601 tcctccggct ttatatccgt taatgaattc cctgttaaaa acggatcaaa aataatatga 2661661 tggtccttcg tttccactgt gattacagaa tgtccgtgat atgtcacttt catttctttc 2661721 acctcgtcac atgattttgt tttttttatt ttcccttttt aaaaagctga aaaacttatg 2661781 ttgtttgatt cttgttaatg acattgaggc ctccggtggc ttcaatgaca gtccctgtca 2661841 caaggtctga gttctcctca cacaagaaag cgataatcct ggcaatatcc tcgcctgtac 2661901 cggatcttcc tatcggcgtt ttttctttgc cgattcgcat tctggcttcc tctatcgatg 2661961 cttctttcat gtcgccgaca atgtctcctg ggcaaaccat gttggcggtt atgccgaatt 2662021 cggcttcttc aatggcaatt gtcttcgtca aagaagccaa gcccactttc gcagcgccaa 2662081 atgccgatcg gtgaagccag ccgggcgcgt gagccgcacc ttggaatccg tacgtaataa 2662141 tgcgtccaaa ttgctgtttt ctcataatag gaataaccgc tttgaataaa tgaaagacgg 2662201 cgcttaaatt tccttccagc atgccatacc attcatcatc agtataatcg gctaactttt 2662261 tacgttcaaa tatgtatggt ccagcgttgt taatcaaaaa gtcgatcctt ccgaagcggt 2662321 ttaaggcagc ctctgcaata cgcagcagat cttctttttt ggtgacatca ccttttacaa 2662381 attgcagccg gtcaagacaa tcgggacagg cttccttcag gcggctgact gcctcctcat 2662441 cctgtctgta attgactgtt actgaatacc cctttgcaag caacgtttca gtcactttgc 2662501 ggcctaaacc cttcgaaccg gcagtaatta aagcatgtcg cacatgaata cctcccaaag 2662561 caacgtcgcc gctttcaata aagtgtttct tcttctactt tactataaaa ggcttgcaat 2662621 atcacttttt acactttggc atacaaaaaa agctgcctgt acagacagct tattctgcag 2662681 gagatgaaga ctcctgatca ggcatatcga cataaccgct ttgatatgct tctgaaatga 2662741 gccttgttgt ctcctggctt tcttgttcat cataaatata gcgttccggt tcttttttca 2662801 tcattctgcc tcccatcatt atagaggtag gttggctata atgacgggat tttatgaagg 2662861 aaattttaac aaactcctgc tgccacgcaa gctttcgctt tttcaagcgc ctgttccacc 2662921 tgtttgaatc cggtgccccc ggcgctcatt cttttttcaa ctgcgtagta agggtctaac 2662981 acagtgtaaa tatcttcttc aaatagtgtg ctcgcctgct gaaactcgcc aaacggcata 2663041 tcgcttaaat agatccctct ttcgatgcat gtgtacacaa gtttcccgac cacttcatgc 2663101 gcttctctga acggcattcc ttttttagct aaataatcgg ccagttccgt cgcgtttgaa 2663161 aagtcttgtt ttgttgcttg cttcatgacg tctttgttta cagtcattgt ttggatcatg 2663221 cctgtgaaga tttgcaggct gccctccacc gttttcaccg tgtcaaacat gccctctttg 2663281 tcttcctgca gatctttgtt gtaagcgagc ggaagtcctt tcatgatcgt aaacagcccc 2663341 atcatatcgc cgtatacgcg tcctgttttg ccgcggatca gctccgccat atcagggttt 2663401 ttcttttgcg gcatcatgct gcttcctgtt gcgtacgtat cgtcaagctc gatgaattta 2663461 aactcctgcg agcaccataa aatgatttct tcagagaaac gggataggtg catcatcagc 2663521 atactgctgt tgcttaaaaa ctccaaaatg aagtctctgt cgctgacgcc gtccaagctg 2663581 ttttcataaa tggcatcaaa gccgagcagt tccgctgaat aatcacggtc aattgggaag 2663641 gttgttcccg cgagcgcccc gcagccgagc ggagatttgt taatccgctt cattgaatcc 2663701 tgaaaacgct ccttgtcgcg ctcaagcatc cagaaatacg caagcagatg gtgagcgaat 2663761 gaaatcggct gggcgcgctg caaatgtgtg tagcccggca gaatcgtttc aacgttcgct 2663821 tccgcctttt caatcagcgc actttggaat gcctcaatca gctcgatgat gtggccgaca 2663881 tgattcttca agtataaatg catgtcagtc gccacctggt cattccggct tctgccggta 2663941 tgcagcttgc cgccaagagg accgatttcg tcaatgagca ttttctcaat gttcaaatga 2664001 atatcctcat aatcgactga gaattccaat gctccctcct ctgctttttg caaaagggta 2664061 ttcaggccct ctcggatttt caactcttct tctgctgtca gaataccgca ttttttcagc 2664121 atggcagcat gtgcgagaga ccctgtaatg tcttcagcaa ctaaattttg gtcaaatgat 2664181 atggacgcgc cgaactcgtc gacccatttt tccggtgttt tttgaaatcg gcctccccaa 2664241 agcttcttca tgctttaatc tgctccttct ttttcacgat gctgttcact tttgtcggaa 2664301 gtccccaaag ctcgataaat ccgattgctg catggtgatc aaatgcatcg tcttttgtat 2664361 atgttgcaag tttttcatca tatagagagt attccgattt acgtccttct acaattgcat 2664421 ggcctttaaa cagcttcacg cggacaatgc ctgtgacatg cttttgcgtt tcttttaaga 2664481 aagcgtgcag cgcgtctttt aacggtgaga accataagcc gttgtaaatg atttctgaca 2664541 ttttttgctc gatgatcggt ttaaagtggg ctacctcttt caccagtgtc aaatcttcta 2664601 attctttatg cgctttgatc agtgtcatcg caccagggca ttcgtatact tcccgggatt 2664661 taatgccgac gaggcggttt tccacgtggt cgatacgtcc gacaccgtgc gcgcccgcca 2664721 tttcattcag cttcaagatc agctcagaaa gcgagtagga aacaccgtca atggagacag 2664781 gcacgccctg ttcaaatgca atttcaatca cttccggcgt gtccggcgtt ttttccagcg 2664841 gagctgttaa atcgtatgca ccttctggcg gcgccgccca tggatcttct aaaatgccgc 2664901 actcattggc gcgtccccag aggttttggt cgatagaata cgggctgtca agattgatcg 2664961 gaatcggaat gccgcggcta gccgcatatt caatttcttc ttcacgtgac cactgccatt 2665021 cgcgaaccgg cgcgatgact tctaggtcag ggtttaatga tttaatggag acttcgaaac 2665081 gaacctggtc atttcctttc cctgtgcatc cgtgggcaat cgcctgtgca tcttcttttt 2665141 ccgcaatttc aaccagtttt ttcgcgatca gcggtcgaga taatgccgaa acaagcgggt 2665201 attttccttc atacattgtg tgggcctgca aagagataag cgcgtaatcc tgtgcaaatt 2665261 cttcttttgc atcgatcacg taggagtttg tcgcgccgac ttcaagcgct ttctgctgaa 2665321 caaatgccaa atctttgccc tcaccgacat ccaggcagca ggcgattaca ttatatcctt 2665381 gctcctgaag ccattttatt gcgacggaag tatcaagacc tcctgagtat gctaatacga 2665441 cttttttctg ttctgacatg ataaaaatcc cctctcaacc gtgtttctat tttgtataaa 2665501 aataaattat atttaataaa aatacatttt gtatgtatac actttaacaa gtacgtttcg 2665561 ttttttcaag ccttttataa aaaaaacttc acctaaattt caggtgaagt ttcatagtat 2665621 ttattcattt acttgtcttt tctgatttct ctgaccacat gcgcaagttc gggaataatc 2665681 agcttattca ttgccagctt tactgcgccg cttgagcctg gcgttgagaa aacagcggta 2665741 tgctgaatga cgccggcagt tgctctcgac atgattgcgg cagagccgat atcctctgta 2665801 taactcagca tcctgaatat ttctccaaag ccgggcagtt ctttcgaaaa cagcggcgtt 2665861 atggcttcaa ttgtgacatc ccgatctgct atgcctgtcc ctccgtttaa gagtaccgcg 2665921 tctgtctgtt catccatgca gcccgcaagc actgaccgtt gcaaagcatc cttttcgtct 2665981 tttacaattt catatgcggc aatatgatga ccggcttctt ctaaaaatga gatcatcagc 2666041 ttgccgcttt tatcggtttc atctgtcctc gtgtcactga cagtaatcac tttgcaccga 2666101 acgatatcgg gagcttcttg tttatgctct tgaacgctca ttggcccacc tcttttatgt 2666161 tttctgtctg tcactatcat gcatcaacaa aaaagcacat tcaagagaat gtgctttcat 2666221 gcgatttatt ttgctaaacg aacaacgtcg cgcgcaatca tgacttcttc atcagtcggg 2666281 atgatcatga cttttactgg agaatgcgga tagctgatga aagcttcctc gccgcgcacg 2666341 ttattaagcg cagggtccca gtatacgccc atgaattcta aaccgcgaag aacgcgttct 2666401 ctgacttcca cactgttttc accgataccg gcagtaaaga tgatcgcatc tacaccgctc 2666461 attcttgcag cgtaagaacc gatgtatttg tggattctgc ttgcgaatac ttcaagagcc 2666521 gtttccgcgc gctcatttcc ttctttcgta gcttcaacga tgtcacgaag atcgcttgag 2666581 aaaccggaaa tgccgagcag tccgcttttt ttgtttaatg tattcagtac ttcgtcagcc 2666641 gtttggcctg ttttctccat gatgtatggg atcagggcag ggtcgatgtt tccagagcgt 2666701 gtgcccattg ctacaccggc aagcggcgta aagcccatgg atgtgtcaat agattttccg 2666761 ccttcaacag cggcaatact tgctccgttt ccaaggtggc aggaaatcag gcgcaagtct 2666821 tttaacggac ggccgagaag ctctgccgca cgctcagtta catatttatg tgaagtgccg 2666881 tggaagccgt atttacggat gccgaatttt tcatagtatt catacggcaa gctgtaaagg 2666941 taagactgct caggcattgt ttggtggaat gctgtatcaa atacagctac cgcaggaaca 2667001 tttggaagca cttctttgaa cgctttaatt ccaacgatat ttgccggatt gtgaagcggt 2667061 gccaattcag aaatatcttc gatttcctta atggtttcat ccgttaataa aacagaatcg 2667121 ctgaattttt ctccgccgtg aacgacacga tggccaattc cgtcaatttc attcaagtct 2667181 ttaataatgc cgaattccgt taacttattc agcagcattt taacagctac cgcatgatct 2667241 ggaatatcag ttacttctgt atttttttcg ccgttcacag aaattgtgaa tacgctgtcg 2667301 gcgataccga ttcgttcaac taaacccttc gttaaaacgg tttctgaagg catttcgaaa 2667361 agctgaaatt tcaaagacga gcttcctgcg ttaattgcaa taattttgga catgattgac 2667421 gctcctttat actctgtatc aacaacttcg tttttcgtac ttttttcccg gtgaatatca 2667481 acatcttctc cgaaaaatat ctgacttttc catttaaaca ttgtcatgtc ggcttttcaa 2667541 gtcaacttgc gtattgataa cgcttacaat aagaagtcgt tattttcaga cacattcact 2667601 ataggttttg tattgatgaa cgcttacaat ttgcggtttt tccctctgta ttttgtgttt 2667661 caaagctgga ttcaattcgt caagtccggt cttcaaaagc ataaataaaa gcagcttagg 2667721 catcgacctc atacggctgt ctaagctgct tttaaaacac ttacttttct tttttaaacc 2667781 attcatcaaa ttgagccatc atatcaagca tcgccttttg attggagaaa gacggaagat 2667841 tcgcaagcag aatttgcccc ggcgctttcg tattctctcc ttgtttctga agcacaagga 2667901 tgcttttggc atgagcttcg tctttaaaaa tagattttgg cagctgcaac agtgcgttga 2667961 tatgaacctt atctttgaaa aactgtttca gcttgccgct ttgggagctc tcaaacaaat 2668021 gattcggaat cataaaaaat aagtagccgc ccggtttggt atgcttgacg ctctgttcaa 2668081 taaacagatg atgagcgaag gaatggcctt cgtcagcttt gagctcaaac gcttctgctc 2668141 cttcgtcatt cggataatag ccgactggca gatcacaaat gaccgtgtca actggatcga 2668201 taaacaacgg ctcaaggctg tcctggtgga aaagctcaag ctcttttttc agaaggttcg 2668261 cttgggcata ggcgatcttc aagagcacat catcaatttc aatgccaaag ctgtttgccg 2668321 ttttttcaga cagctggttc agcacggtaa acagaaggtt cccagttccc agggctggat 2668381 caagaatggt cagttccttt ttgtccgcca taaatttatt caccaaatag ctgatgaaaa 2668441 gcccgatcgt atccggcgtc atttgtctgt ttggatgcga gatatctttc attcctttaa 2668501 ggacggcaag ctgaaaagcc ttgcgtaccc actcatgctc atacgtgccg aattccgctt 2668561 tttcaagcag agcctgaagt tgtttggttt tctgatcagc aggcagtttc agctgatccg 2668621 ttttttcaag aaaatacatt tctcctgctt cggccagcgc ctctatatat gaaatctgca 2668681 attcattctt tatcataatc gcggcttcgt ttaacagctc atacaccgca cctacatggt 2668741 ctttttgcat attgtgttcc tccttgccat gaaaaaagct ccggcggcag cctggagctt 2668801 ttttccctgc ttactttact aatgccttag cagcctcaat tggcttttca tagttcgggt 2668861 ggtttgttgc ttcgcttaca tattcagcgt aaacgacttt tccgttctca tcaaggacaa 2668921 atacggaacg cgcaagcaga cgaagttctt taatatacac accgaacgct tcgccaaatg 2668981 acatatctct gtggtcagac agtgtttcca ctttgtcaat tccgttagcg ccgcaccagc 2669041 gcgcttgcgc gaatggaagg tctgcactga ttgtgtagac gttgacatct ccaagctttg 2669101 cagcttcttc gttaaaacgg cgtgtttgtg catcacaaac acctgtatca attgaaggga 2669161 taacagaaat aatcgttacc tttcctttca tgtcagctaa cgatttttct tcaaggctgt 2669221 tagtcagcac tgtgaaatca ggagcttgat ctcctacctt cacttcttgt ccgacaagtg 2669281 taaccggacc gcctttgaat gtaatttcag ccattataat tcctcccttt tgtatgtatg 2669341 tctctatcat agtaaagttt cctgcaaact gcaaagttta tgccaaaaaa aagttaactg 2669401 cggccagcgc agttaacctt tttttaataa ttcatattgt tcatttggtt ttgattttgg 2669461 ccttggcttt ggtttttgtt atttttcttg aacatttgct ggatgcgctc gagtgtttga 2669521 ggggctgcgt ctaaaatttt ctctattaaa tgggtatttt catctaaatg aagcattctg 2669581 atgcctgtcg atccgacaat taaaaacgcg atcggcgtaa tggacacacc gcccccgctt 2669641 ccgcctccga aaggaagttt ctgttctctt gtctcatcgt cttccgattt cttttcggcc 2669701 ggctttccgc caaactcgct tccgcctgcg gcgaatccga atccaacttt agaaacagtt 2669761 aaaatcacac ttccatcagg cgtttccact ggatctccga tgatggtgtt aacatcaatc 2669821 atttccttca agttttccat tgcggttttc attaaacctt ggatgggatg gtctgccata 2669881 tacgcttcct ccttaaactg atgaatcatt ctttgaagtc attctagccg acggattctt 2669941 ctttaatacg gatagctccc gtccgtattt gacgaatttg aaagctgcaa gcatagcatg 2670001 tccaaagcga aaaaagaata tacactgaaa atgggtcttg gaaacaggga cttgaaacga 2670061 cgggatcacc tcatagacag gtttattcac aaagtccagg tggtcgtaga gcattgctgc 2670121 gataccgccc ttcacgcccc atacagcacc ggttaacaca cctgtcactg ccgcgtcctg 2670181 aattccgatt actgtaaccc attctagttt tgtgatatgt aaatgcgcga gaaaagacgc 2670241 gctgattttc cgcagtctgg tgacctgatg caaaagcatt tcgattttat taatgctttg 2670301 ctgcacatcg ttttgtgtaa tttttttctt tccgctgctt tttttcattt tggattcagt 2670361 tttttgtttg atatccactg ttccgtcttc tttgttcacc ttaatcgccg ggattgtttt 2670421 tttgatcctt ataaggccaa acagcgccgt aatcttcaag gtcaatttgt cattatcatc 2670481 ggcatgaaga tactccagcg cgacatggat tttcattctg agaagcagta cgatccctat 2670541 gagaataaga atggctgtca gtacatacac catattcttc acttcctcta ggagcattat 2670601 cgccaattcc taaaaaaata aacccggacg gaagtccggg ttatcggtta tttgcggtat 2670661 aatttttcat gcaccacggt ggtatccgcg atgtaatcat gaatcccttg ttttgtaggt 2670721 gaaaaggcaa caacgatata taaaatccaa atcttatcaa tataccgtcc aaccacttca 2670781 cgaaaaatca ctgtactcca tgtcagcttg ctatcttgct tcacagaaac cactttgagg 2670841 ccgaacacca ttttaccaag cgtctgcctg aagtattttg tcatgagtgc gaaataggca 2670901 agatacacaa taagcgttgt cacactgtag gccgagaagg taaacatgcc ggatgttttc 2670961 ggcagatcca atacggtaaa gaggggagaa acgagcaaat ggtttaatcc ccatatcacg 2671021 agccaatcaa gcaggaaagc ccagaaacga acccaaaagc cagcataggc atgtgtcagc 2671081 agctccgctt cttgcgggcc tttgatgtca ttgcgctcta actcttcata tgtcgcgtcc 2671141 attattgttc cctcctactt cgcatagaga tacatcattc tcggcgaacc ggattgcgat 2671201 agaatttctc tcatattcaa aaaatcaatt tcacttttaa acattttgtt cgcgcccatg 2671261 gaaaacagtg agcctaatcc gaagctttcc tcataagaaa tgacagaggc gtttttcaaa 2671321 tccttgtgat cctttttcat ggccgtaatg gtatcgtcat aaaaaccaag ctcatcaacg 2671381 aggttcagtt ttttcgcctg ccgtccgtca tacacgcggc cgtccgcaat tttctttacc 2671441 tctgctttcg gcatgccgcg cccttttgaa atgacatcaa caaagccttc atacgaatta 2671501 tcaaccatcg attgcatgat gtttttttct tctttcgtca tctcacggga aggagacata 2671561 atgtccttat gggccccgct cttaatcgtt tcaaaagaaa tgccaagctt gtcggcaagc 2671621 tttgaataat tgacgctttc cataatgacg ccgagtgacc cggtcagggt ttccggtgtc 2671681 gcaaaaatct tatcagccgc tgttgagatg taatagcctc ctgatgctgc catcgaaccc 2671741 attgacacgt aaatcggttt tttcgtttct ttcttgattt cttccagttt cttatgtatt 2671801 tcagcacttt catacactcc gccacccgga gaattcacct tcagaacgat acctttgacc 2671861 gtcttgtcat cttttgcgcg ctcaaggttt tttaagaacg ttctgtggtt atatccgtct 2671921 gcaccaagca gactgcttga gtccccatta tcctgaatgg tgccgctgac ctctaatacg 2671981 gcaattttac ttgagggact gccgttttcc agcgtcttct cctgcgattc atccgtcagt 2672041 gatgtgagat ccgtttgagc gcctttgacg ctttcaaaga aactcataga gatgctgacg 2672101 ataatagaca cgccgaaaat ccccagagca atcactaatg caatccatct ttttgcattc 2672161 attttttctc ctcctttttc ctaaactctc tcattatacg attcaatatg aaaaatgttt 2672221 cacttcatga gaaagctccg gcttaacggg ctgccggcaa acgtggtaca cttatggcca 2672281 aaggtatttt atcacaaata ctggatggca gaaaaactta aatatgacag caaaggggaa 2672341 atgggatatg accgatcaac gccgtaatgt ttattttttt cacaaacagg atcaggaaac 2672401 gaacgaacaa gcccgctcgt taacacaatt agcggaagag catggattta ccgttgtgaa 2672461 ccagcactca gacgccaata ttatcgctag cattggcggg gacggcacat ttttgcaggc 2672521 agtcagaaag acgaattttc gtgacgactg cttgtacgtc ggcattacca aaaaggggaa 2672581 agctcattta tattgcgact ttcatagtga tgagcgagaa aaaatggtcg atgcaatgac 2672641 gtttgaacaa attgaagtga gaaaataccc gctgattgaa gtgacagtgg atcaagccag 2672701 tccttttcac tgcttaaacg aggtatccat ccgctcaagc atcatcaaaa cctttgtgat 2672761 ggacgtgctg attgacgatc tgcactttga aacgtttaga ggtgacggaa tgattatctc 2672821 aacgcctaca gggagcaccg cctataacaa gtctgttgca ggagctgttg ttgatccatt 2672881 gcttccatgc atgcaggtat cagagcttgc atcccttaac aataatacct accggacact 2672941 cggctcgcca tttgtcctca gctctgaccg aaagctgacc cttcgtgtgg tgcaggacgg 2673001 caacgaacac ccaatcatcg gcttggacaa tgaagcactc agcacgagaa atgtgaaaac 2673061 gatcgaaatc aaactgtcta ataagaaaat caaaacagtc aaactaaagg acaattcatt 2673121 ttgggaaaaa gtgaagcgta cttttttata gaaaataaaa ggacaggctg ctgcctgtcc 2673181 ttttatgatt tctcatatac aatctggccg ttaatcacgg tttttttaat ctctaaaaga 2673241 tgaagctgtg cggggtcaat ggcaaacgga tcaccactga gaactgtaaa atccgcgtca 2673301 tagccttccg caatttttcc gcgtgacttc tctttataaa tgataccggc gctaccttct 2673361 gtataaagct ttatcgcttc atatacaggt aaacattcac tttcattata gcttggcccg 2673421 ttttgctcat gactgctttt ccggaggacc gcggactgga tccctagaag cgggtcaaca 2673481 ggctcaatcg gggcgtctga accgcccgcg cataaaatgc ctttagatat gagggttttc 2673541 caggcaaatg cagtcttcat ccggtctttt ccgagacggt caatgaccca cggaaagtcg 2673601 cttgcaacga agtgcggctg aaggtcaagt gcgatcggca tgcgtgctgc tctctcgatt 2673661 aattcgttat caagcacttg agcatgaata agccgatcat gccggccgtt tttgggcgga 2673721 tgcttttcta ttgcgttcag cactttttca aaagcaagat cgccgattgc atgaacagca 2673781 acctccatcc ctttttctct cgctttgcga atgagccggc caagggtttc gtcatcgtga 2673841 acctgaacac catttgttga tggatcatcc tgatatggtt ctttcaataa agccgttctc 2673901 ccgccaagcg ccccgtccgc aaagattttc atagcaccga actccacata cgggccggac 2673961 agcttctcca gctgctccca tcgatcgaca gcttcatgat gaacgagcaa atggcagcga 2674021 aacggatact ttccgccagc ggcagctttc tcataagctt tcatcggcac cgaaacatca 2674081 ccataatagg acaagtcttc cgaatgaccg cccgtcaggc cttttgtcca gcaatccttt 2674141 attgcagccg ttaatgcctc atcaacatag tgctgggaga ctggcgggac agccttcaga 2674201 atcaaatcct gcgccttatc aaacaggagt ccggtcggct cgccatttgc atcttttacg 2674261 atgactccgc cgtcaggatc aggagtattt cttgaaattc ccgctgcttg aagagccgca 2674321 gaattgacag ctattgcatg ccggcatata cgcttgagca agacgggcct gtcaggaaac 2674381 aggcgatcaa gatcatgctt agtcaagtag tcaggtgtct caaactgatt ttcattccag 2674441 ccttctccaa tgagccaatc gtttttagga agctgccgct ctctttcctt cgcagcctgt 2674501 aaaattgaat ctttcgacgt cagtgcggac agatcgagct gaagctgttt ctcaccgtgg 2674561 ccgatcaaat gtagatggct gtcaacaaaa ccggggaaca tcactgctcc gttcaggctg 2674621 atttcttctg tttccggcga cccgtacttt tccttcaaac gttcatagct gccggtgcct 2674681 tttataacac catcctcaac ataaactgcc tcagtccgat cgccttcttc gagcatcgta 2674741 taaatgaaac cgccgtgcca tatcgccttc attcacgttc actctctttc tttacgcctt 2674801 tttattggct ttgagctgtt cttcacgttt tcttaattcc actcgtctga tttttgcaga 2674861 agccgttttc ggcaggcttt ccacaaattc aatttctcta ggatatttgt atggagcggt 2674921 aatcgtcttc acatggtttt gcagcatttt gacaagctca tcactgcgtt tttcatgatt 2674981 ttgcaggaca acatatgcct ttacgatgga gcctctgatt tcatcagggc ttgcgacaac 2675041 agcacattct tttacttctg ggtgcttaac aagcgcgtct tccacctcga aaggcccgat 2675101 cgtatagccg gagctgataa taatatcgtc atttcggctt tcaaaccaga agtaaccttc 2675161 ctcatctttt cttgctctgt ctcccgttag gaaataatcg ccgcgaattt gtgttttcat 2675221 tctttccgga tctttaaaat actctttaaa gagcgcaggc gtactgaggt gaacagcgat 2675281 atcgccaacc tcaccaggtt tgcagatttc accgtcttca tttatgatct ccacctgatt 2675341 tcccggtgtc ggttttccca tgcttcccgg tttaataggc gtatctttca aaacaccaac 2675401 caaaagcgtg ctttctgttt ggccatatcc gtcccgtacc ttaatgccaa agtgcttttg 2675461 gaaaacatca atgacttcac ggttgagcgg ctcacctgcg gaaacagcgc tgtgcagggc 2675521 agaaagatca aagcgtttca agccttcaac cttcgccatt aagcggtatt ctgtcggagt 2675581 gcagcagaaa acattgattt tgtagcgatt taaaagctct agatattttt ctgctttgaa 2675641 tctgccgtgg tacacaaaac cggttgctcc gctgccaagc accgctaaaa acggactcca 2675701 tacccacttt tgccagccag gggcagcagt tgcccagacg atatcctttt cagaaatgtc 2675761 aagccaagcg ccggcagaag tttttaaatg agcaaatgcc catccatgtg tatgtacaac 2675821 acctttcggc tgacctgttg tcccggatgt ataagataag aaagccatat catctcttgt 2675881 tgtgtcagct gttttaaatt ggcttccgtc cgcttcaatt gataagaggt ttttccagcc 2675941 ggcatcattt tcaccaatag acagtgtaat cagtttgtca gccgtactga catcccggaa 2676001 agcgccaata aattcggagt agacgatagc gccttttacc tctgcatgtt caatccggta 2676061 ttcaagatct ttcgcgcgaa gcatttcgga gcacggaatg acaaccattc ctgatttcag 2676121 gatagccaaa taaacagcat aggcttcaag cacccgcgga accattacaa tcagcttgtc 2676181 tcccttttta aatccaagat cagctaaggc cgctccgatt ttatttgttt cttccatcag 2676241 cttttcatac gaccaagatt cttgcttgcc cgactcgtcc tcccaaagaa gagcggtttt 2676301 ttgtccagca gcactgaact tttccatttc attcactaaa ttatattgca caggggcaat 2676361 taaatcttca cgttttaaca cgaacaactc ctcactttct ccacccatta tacataaata 2676421 caggctcttt ccgtaaggat atgcctaaaa gcaacctctg taaacataga ttttataggc 2676481 cgctggtcct tttttatatg taaaaaatga aaaagagtgg ggataccccc actcctaagc 2676541 cattatgtga aattgtaaat tagaattgtc ctccgcccat gttttgttga gcaaaagata 2676601 caagacgttt tgtgatctct cctccaacag aaccgttagc gcgagaagtt gtgtctgctc 2676661 caaggtttac accgaattca gaagcgattt ctaatttcat ttggtcgatc gcttgagcag 2676721 ctcctggtac taaaaggttg ttgctgttac ctgagttatt gttagccatg tgtctcacct 2676781 ccttgtgagt atagaatgtg tcaaaacaca tggcttcatt cagaaaaact ttggtaattg 2676841 tatacaggag ctgaaaattg atttaaaaga gttcagcgaa tttatcgtta gcttcttgtt 2676901 cgctataaag ggtcattgtc tcaatgttat ctaccgcttc ttgaatatac ggctcgaaat 2676961 caacaaagct ttcaaagtgt tcaattttct cttttttagg gcgtgttttc gggcttggcg 2677021 gtgtaaagat cgtgcagcag tcttcaaacg gctgaatact tgtctcatat gtgccaattt 2677081 cccgtgattt ttcgatgatt tctgttttgt ccatggcgat tagcggacgc aaaatcggtg 2677141 ttgacgtcac cgcattaatt gcatacatgc tttcaagcgt ttggctcgct acctgaccga 2677201 ggctttctcc cgtaataatg gcaagcccgt ttctcttttc tctgattctg tcggctatct 2677261 gaagcatgag gcggcgggtt gccgtcattg tgtaattttc aggaatttgt ttttggatga 2677321 gctcttgcgt ttttgtaaat ggaacaatat gaagtgtcat gcttccccca aaacgggaca 2677381 gacatttcgc cagatccatt accttttgct ttgcgcgctc gcttgtgtat ggcgggctga 2677441 agaaatgaac agcttctacc gacaatcccc gtttcatcgc ataaaaaccg gccacagggc 2677501 tgtcaaaacc gccagaaagc atcagcatcg cttttcctgc tgaaccaact ggcagcccgc 2677561 ctgcaccttt ttcatcacga attgtcaaaa atgttgcttc ttccctgatt tcgattctga 2677621 gcgggatgtc tgggttgcga acatcgaccg tcaatccttc tgtatttcgc aaaatatggc 2677681 cgccgatttc agcgttcatc tggtttgtat ctaattcaaa ttgcttatac gctctctttg 2677741 tcgcgacttt aaacgtatca cctggtttat actgatcttt gatagccttt agtgcggttg 2677801 ccttaatatc atcaaggcgg ctgtcacact taattgccag gctgaagctt tgaatcccaa 2677861 acacttgctt taaatgagga aaaagagcct caggatcctc tccatttaat gtaatcgtca 2677921 tacgatccct gttggaaaag tattttaaat tcggatagtc tttcaaaacg agtctgatgt 2677981 tttgttttaa gcgctcaata aagctttttc tgtttttgcc tttggtcgaa atttccccaa 2678041 aacgaattaa tatatgatcg taattcatgt tctacctcat catttccctt aattttttga 2678101 tgccaggacg aagcgcgttc ataaacggtt ctgccacatc gcttgtctgg ctgtaattta 2678161 aactgattct gatgctgctt ccggcaatct gctctccttt gcccatctct aagagaacct 2678221 tgctgggctt atgttctttt gccgagcaag ccgatgttgt ggagacgaat atatcctgtt 2678281 cctcaagcat gtgtaaaagc acttccgctt taatccccgg tacagagaaa ttaataatgt 2678341 gcggcgcgct attcatttga ggcgtgttga taacgacgcc ctcaatttca ctcagcctat 2678401 tcataaacaa ttcctttacg gcagtcatcg tgtcaagccg tgtgtcaaaa tcagcagagg 2678461 ccagattaat ggccttggca agcgaaaccg caccagcagt atgttctgtt ccggcccgta 2678521 tgcctttttg ctgagagcct cccgttatga gcggaataag gcgtgttcct tcttttacaa 2678581 taagtgcgcc tgtccccttt aggccgtgaa atttatgccc cgaaattgaa catagatcaa 2678641 tgccggcctt ttcaattgcc aagggcactt tatagatgcc ctgcacataa tcgacgtgaa 2678701 acaaaatgtt cgaatgctct ttcagcactt ctcctgccgc ttcaatcggc tgcacggaac 2678761 cgacttcatt gttcacatgc atcatgctga caagcacggt atcgggacgg atggctgctt 2678821 ttagatcttc aatagaaaca aatccgtctt cattcacaga aagataagtg atatcaaacc 2678881 cgaacaactc tttcagctgt tctaacgatt ccgtaacgga tggatgttca atagaagtgg 2678941 caatgatatg tttgcctgtt tttatctttg acaaagccgc tccttttaaa gccgcattat 2679001 tggcttctgt ggcgcctgac gtaaatacaa tatcatattt ttttaggcct aaggaccttt 2679061 tgatttgatt tttggctgct tgaagcagct gttccgtttc ggctccatat cggtgcaaag 2679121 atgaaggatt gccaaagtat cggctgctcg tctgttcata tacgttcaag acttcatcgt 2679181 aaggcttcgt cgttgaacta ttatctaaat atatcatctt ttttactcct ttatgaaagc 2679241 ggtacaaggt atgatattta tgttaccata acaaaattta atagaaaatt acgaaaaact 2679301 agtattgact tctaattttt ttaccatata ataagatttg ttcgtttcgt catattatct 2679361 gacaattaat tgacagaata ttttaacata attattagga ggattttttt catgaaacac 2679421 tcactgcctg tcaaagatac cattattatt ggtttcatgc tatttgcgtt attctttgga 2679481 gcaggaaata tgatttatcc gccggaactt ggacaagcag ccggacacaa cgtctggaag 2679541 gccatcggcg gatttttact gacaggggta ggcctgccgc ttctcggcat tatcgccatc 2679601 gcattaaccg gtaaggacgc taaaggcctt gctgacaaag cgcaccctgt tttcggcaca 2679661 atctttactg tcgtgcttta tttatcaatc ggaccattat tcgccatccc gagaacagga 2679721 actgtttcat atgaaattgg cgctgttccg tttttgactg gtgtaccaga aagactttct 2679781 ttattaatat ttacacttat ctttttcggc gttacgtact atttagcgtt aaacccatct 2679841 aaggttgtgg atcgagtcgg aaaaattctg actcccatca aattcacaat tattttaatc 2679901 attgttctca aagccatctt cacgccgatg ggcggattgg gcgccgtgac agaagcatat 2679961 aaaggaacac cggtttttaa aggattttta gaaggctata aaacaatgga cgcacttgct 2680021 tcaattgtat ttggcgttgt cgttgtaaat gctgtaaaaa gcaaaggcgt tacacagtct 2680081 aaagctcttg ctgcagcctg cattaaagca ggtgtgattg ccgctttagg cctgactttc 2680141 atttatgtat cccttgctta tttaggtgca acaagcacaa atgccattgg tcctgttggt 2680201 gaaggagcta aaattttatc tgcgtcttcc cattatttat tcggttcatt gggcaacatc 2680261 gtactcggag cagcgattac agtcgcatgt ttaacaacaa gcatcggcct tgtcacatct 2680321 tgcggccaat atttttcaaa acttattccg gcattatcat ataaaattgt cgttacgatt 2680381 gtcacgttat tcagcttgat cattgcgaat ttcggactcg cgcaaattat cgcgttttct 2680441 gttcctattt tatcagctat ctatccgctt gccattgtca ttatcgttct ttccttcatc 2680501 gataagatct ttaaagaaag acgcgaagtg tacatcgcat gcttgatcgg tacaggactt 2680561 ttcagtattt tagacggtat caaagcagcc ggtttttcac ttggatcttt agatgtgttt 2680621 ctaaatgcga atcttcctct ttacagcctc ggcatcggct gggtgcttcc aggaatcgtc 2680681 ggagcggtta tcggctatgt gctgacctta ttcatcggac catccaaaca gcttaatgaa 2680741 ataagttaat gtcacagaac gcctgcgtta ttgcgcaggc gttttgtaat aaaaaaagag 2680801 cctgctcatt acactgcggg ctctttttca tggtcgtgat tatctaagcg gatatgtcag 2680861 ctttgatttt ttcaactgca cctggcgcag ccttttctac agcggcagcg gcaatttcat 2680921 aagagtcgtc ataatcaaaa gcataaaaac gtctttccgc ttctttcagc tgttcagata 2680981 aaatatgatt ctggcttctg aaccggtttc cgaactgaat gattttttca atgaggatga 2681041 cctgctcgac aagttcctct gattcccggc ttgccctgtt gacgatatct tctgcttgtt 2681101 tcaaatgggc tccggcttct tccatattta atggaagttc gtttagttga ttgaccgttt 2681161 cttgaatatg atgatgcgcg ttctccagca tctcttgaat atggctcgga atgcctggaa 2681221 tgttgctagt cttcagcagt cttgctgtct cagaaattgt ttttttcaaa ttgctgagcg 2681281 tctccctcgc ctgaagctct tcttttctca gcgcttgcag attttcacga tactcggcat 2681341 gctctttttt cacttcttca atttgcttct ctattgaagc aacttcttct actaaaagtg 2681401 agtaggcgac atgctctgca tcaagcttat ctttaacgga tgatagcagc tttccaattt 2681461 catcaaggcg cttttcaaaa gcctgctgtt tgccgagctc accggctgtc agcctgtagc 2681521 tttccttcac cagctcagtt tccgctttcg tatgctcttt ctcttcttta agcttgtcgt 2681581 aagcaataat caattcaggc attttgctta gtacggattg accggcttca acttcgccct 2681641 ccagctgctg ataaacagat tgaatatttt cgtcaatgag ctgcaggatt gcggacgctt 2681701 catcaatatc cagttcagtc atcaggacat gttccgctcg tttcagctgg tttgacagat 2681761 tttctaattc cttatcaagc tggatatgct caagcttgta ccctttttct ttcatttcgc 2681821 catagccatc cttgagcttt gcaatctgtc cgggcaccgt ctgtttacag tcagctaaca 2681881 gcttcggcac atcatctatg tatgactgaa gccgttcaag attgcggtcc tgctcaagca 2681941 gtacttttcg tgcagtaata tagtttccgc cttctgtttc ttcttcaaat tgtttgatgc 2682001 cgctccaaat ttcgtccaga tccttttcaa ggctgtcata aagctccccg taaaggtggc 2682061 tgtaagccag caggtttttt cgagatttcg aatagcgctc cctcacctgt tcaatctctt 2682121 cacggctctt ttcctcactt gtgacaagat cgctgatttc ccgaagaatc ttttcaatgc 2682181 ttgattcagc cgctgtcagc aggtcgtcga tatgaacgag cacttgattg gcctttttaa 2682241 accggtattt gtctgcattt tcctcggcat cataaaggag ctcttcaact ttcggcatgt 2682301 gggctgtgac aatctcatcc cattcttcac gccacttctc aaagaactct tctgtctgac 2682361 ccgtcatttt taaatgtttt attttagaca tttcttccac gatcgaccga ttcagaattt 2682421 caatcttcca cgattccagc cggtcgattt cggcgtagat ttttttcctg aaaaagtagc 2682481 ctgccgcaaa cagcgcaagc agtacaatta ataatccaat gacaaactcc ataatgagcc 2682541 cccttgctgt ttaccttaat ctgtcagggt gttttattta ttcagaaaga tttcaggata 2682601 tgtattgaga aaaactgtcg ttttcattgt tattatgata ccatgtaaca aacatttttt 2682661 gaccagaaat caaaaacttt ttgtgcaaaa tcggcaggat ttgactattt tttcatgggg 2682721 tgacatcaat gcaaaagcga gacggacata ttcacacacc attttgccct cacggctcca 2682781 atgacacact cagacaatat gcagaagaag ccttaaaaaa agggttcgaa tcgattactt 2682841 ttaccgaaca cgccccattg ccgccatctt ttaccgatcc cacgccgctg aaagacagcg 2682901 cgatggcgca agcttctttg gaacgctata ttcatgaaat ttccggatta aaaaaagaat 2682961 atcgcggaca gcttagcata cggacagggc ttgaagtcga ttatatcgct gaatttgaag 2683021 acgaaattac attattccta gacacatacg ggccatattt agatgacagc atcttatccg 2683081 ttcatttttt gcgcacagac tcttcctatc tatgccttga ttatgacgag cataccttca 2683141 aagagctgat ttcagcctgc ggaagcattg aagcggtata tgaacaatat taccggagta 2683201 tctattcttc cattgtagca tctctcggcg tttataagcc aaaaagagtc ggtcacatca 2683261 cactcgtcca aaaattcatc aagctgtttc catacagcat gtcagagcat attcgcggcc 2683321 tcgtttctct gtgcctgaat gccattgaag aaaacggaat ggagctcgac ttcaatactt 2683381 ccggcttaag aaaaacttac gctggcggta tttatatcga ggattggatg ctgaatgaag 2683441 cgaagcaaaa gaagatcccg cttgtgtttg ggtctgatgc ccatcaagcg ggagatgtcg 2683501 gatatgcgta tgaggcgttt ttggaacggt gctagttggt gagcgccacg tctcctgtcc 2683561 ggaagacgct tctgatccaa atcttgattt cttcaaaata cattttataa aaatacggct 2683621 cgtgcggctg catgtagagt acttctgaaa tatattgagg ctggagatag ggcatcatca 2683681 agagagattt taattggaga ataaaatgag gcagcggcag cgttaaatat tcacgctgtt 2683741 tttctccttc ctcaatgatc agctggaaga tatacttttc cttcattaga tatgtcgaca 2683801 taatttccct gattaatgtg gagtcaattg tgacttcccg gtagacaaaa cgagttaatt 2683861 gacgatgatt atgctgatag gataaaatat cgaaaaccaa ttgaagaagc tgttcctgcg 2683921 tgctttgagt agagatattg cttgccgctg tttcaagcgt tttgctgtag ccttcgtaaa 2683981 actctgaaac taagtgttcc atcaagcctc ctttgccttt aaaatagtag gagatgtgcg 2684041 caacatttac atcagctgac tttgcgattt cacggacaga cgtgccagaa aatccttttt 2684101 ggttaaaaag catgacagca gattcaataa ttttgtcttt ggtgcttact ttcatacggc 2684161 tcactccttc ctcttgatac tattcaagca gaaagccgct gttcctgtaa gaacttatcg 2684221 acaaatgccg gcagaaaagc cggaactttg ttttatatta tagaaaaagt gagggttttc 2684281 catgttccat gtcgaaaaac aatctggaga taaagaaaaa gactatcagc ttctgctaaa 2684341 acagctcgaa gccatgaccg aagacgaaac agaccaaata gctaactatg caaatgcctc 2684401 agcactgctg tatcattcgc tgcctgaagt caactgggcg ggtttctatt ttgccaaaga 2684461 agaggatgga cagcttgtgt taggtccgtt ccaaggcctg ccggcatgtg ttcggattcc 2684521 tttcggcaga ggggtttgcg gcacagcgta cgcaaacgga aaagtggaac gtattgagga 2684581 tgtaaacgcg tttccgggac atatcgcctg cgatgcagcg tctcaatcag aaattgtgct 2684641 tccgattcgt gtagacggaa aaattgtcgg cgtcttggac atcgacagcc cagtgaaaaa 2684701 ccgtttcgac gaaattgatg aaaaatactt aactcaattt gccgaaacgc tagaaaaagc 2684761 gttagcgcag taatataaaa gcccaaaact gatatcgttt tgggcttttt ttattttatt 2684821 gagtcatgaa tcatcaagcg gtttttcccg ctccgtttcg cgctgtagag cgcttcatct 2684881 gcctcatgca caagctcttt cagcgacttt tttgtttctg tcgtccagca ggagataccg 2684941 caggaaatgg ttacctcggg tttcgtattt tttctgaccg cgtaaaccag tcgctcggta 2685001 atccgtttcc ccactgcaac cggcacattt ggcaaataaa tcgccagctc ctctcctccc 2685061 cagcgggcac cgacatcatg ctttcggatg ttgcttttaa tcactgaagc gacttgaatt 2685121 aaaatctcgt ccccagtctg atggccgtac gtatcattta catttttaaa attatcaata 2685181 tcaacaagaa taaaaacacc cttttgatgg attttcatgc tgtattgaat tttttcatct 2685241 aaatacgctc gtgaatacag ttcagtcagc tgatctgttt tcacgagatg ctcaaggcgg 2685301 tcgcgaagca ttgaattggt tacagccagt gtcgcgtgat gaatcagcgc ctgaaacagc 2685361 ttgtacattt caaatgtaaa agcgtacagc tcctgtttca ataaaaccgc aaagcctaaa 2685421 agccggtcgt tttgaatcat cggagcagcc atcagcgagc cgtaccccgc cttcccaaaa 2685481 acagactggc cattcccgat gaaaacccct ttttcacctt catacagctt ttctttcagc 2685541 tcattataaa aatctgacgg cttcgcttct ttaaaaaatg ctgtgctgcc tgggagcaat 2685601 gttaggtttt caaaatggtc tatatgaaaa aatcccactt cttctgcctg aaacgattct 2685661 gccattctca cagccagatc attcattgta tcagtcaatg tcagccgctg attcaggcgt 2685721 cgtgatgttt cattaatcaa ttccaaattt gcgatgcttg ctttggattg ttcgtagagc 2685781 tgggcatttt caaacgcttt tcccgcggcg tttgctaaca gcgacatttc atcaaggcag 2685841 gcatcagtaa gaaagctgtc acccgttcct tcagccttca acaccccgta tgtgccctgc 2685901 tgtcctttga tcggaatata ggcgacagat tcatttttcc gcaaaatgtc tccggacaaa 2685961 tacactttga gcgcaaagga atcggatttt tccccttcca tatacagctc ttttgcagga 2686021 atccctaaac attggtcttg atcgtgcgat ataaataaag aaaactcaaa aagagaaaat 2686081 gtgcttgtca agctttctaa aagctgcttc agcacatctg tctgatcaag cagtgaatgg 2686141 aacagctctg tcattttgta tatctttttt tggtagatcg ttttgttata gagtctttcc 2686201 tgtttcatcg actggtttaa aaatgaagca accacgtccg gaagcccttc aggaatctct 2686261 tcatcctgcc tgcacgcaag atggaaacgc ctgccggagc cgtcctcaat cagataacat 2686321 gaagcgttta tttttgaagc ggaaaaacgc gcttcaccat ctgccagttt tgtcacaaag 2686381 tctgatggtg acggtgtaag cgaaacacaa agggttgaaa aataggtttg aatagccgaa 2686441 gtcagccata tgaaagagtc ggtgaatgtg actttttcag atttggttaa taaaaaatcg 2686501 agcatatgat aatgaaaggc ggataattga tctttagttt gttctaccat gtttttatca 2686561 cctaaaagtt taccactaat ttttgtttat tatatcataa acggtgaagc aataatggag 2686621 gaatggttga cttcaaaaca aataaattat ataatgacct ttgtgtgaaa tattgcagcc 2686681 tttttgttca gcttctatgt tttcattttg ttccttatca ataaggtgta tcgtgtaact 2686741 ctctgctgct ggagcgagga tacatgaaaa caaaatgtgc atggtcgaat agagcagacg 2686801 gtttttattt tccacaaaaa taaaaccaaa ggaggagtca cattatggct cgctatacag 2686861 gtccatcttg gaaactgtcc cgccgtctag gaatctctct tagcggtaca ggaaaagaat 2686921 tagaaaaacg cccttacgct ccaggtccac acggcccagg acaacgtaaa aaattatcag 2686981 aatacggttt gcaattgcaa gaaaagcaaa agcttcgtca catgtacggt gtaaacgaac 2687041 gtcaattccg cactttgttt gacaaagctg gcaaactagc tggtaaacac ggtgaaaact 2687101 tcatgattct tttagattct cgtcttgata acgttgtgta caagctaggt ttagcacgta 2687161 ctcgccgtca agctcgccaa ttggttaacc acggtcacat tcttgtagac ggaagccgcg 2687221 ttgacatccc gtcttaccta gtgaaacctg gtcaaacaat cggtgttcgc gaaaaatcaa 2687281 gaaacctttc tatcatcaaa gaatctgttg aagtgaacaa cttcgttcct gaatacctta 2687341 ctttcgacgc tgaaaagctt gaaggtactt tcactcgtct tcctgagcgt tctgaacttg 2687401 ctccggaaat taacgaagcg cttatcgttg agttctactc tcgttaatcg ttttaaaaac 2687461 ccctgccgct atgcggtcgg ggttttttta tcggctttcg cctcttgctg gccaacacta 2687521 tcttgcgcct gctgctccca atgatcccgc tgcagccgtt cttttgcaat cgtacacatg 2687581 agattcacgc tttagcgctc ctttcattta aaaggtggtg attggtcgtg tttgccctat 2687641 ctaatatact cttttccttt cattcctatg cggtaaacaa aaagatcctt tgccttcagt 2687701 ggcaaaggat ctttttctta tttatacgtc acaaggaagt attttttctt cccgcggcgc 2687761 agaacagtaa attggttttc gatgcggtct tcacctgata gggtataatt tatttccgtc 2687821 tggcgttcac cgttaatgta aacagctccg ttttggatgt cttcacgcgc ttggcgttta 2687881 gaaggagata atttagattg caccaacaca tctacaagtg aaagctcttg ggtgctgtca 2687941 acttccatag aaggaacatc tttaaagcct acttttacgt cttgagcaga aagctcttta 2688001 atattgccgc tgaacagcgc ttgggagatg ttgatggctt gctccagcgc ctcgcgtccg 2688061 tgaacaagtg atgtcacttc ttctgccagg cgtttttgcg cttcacgttt ttctggcgcc 2688121 gtttctgttt tttcagcgta tgcttcaatt tcctcttttg aaaggaacgt gaagtatttc 2688181 aagtatttga caacgtcacg gtcgtctgtg ttgatccaga attgatagaa ttcatatggc 2688241 gatgtttttt ctttatcaag ccagatcgcg ccgccttccg tttttccgaa cttcgtgccg 2688301 tctgcttttg tgacaagcgg aatcgttagg ccaaacgctt ttgctccttc ttcttctgat 2688361 tttctgatca gttcaagacc cgctgtgatg ttgccccact gatcgcttcc gccgatttgc 2688421 agtttacagt ttttgtctct gtaaagattt aagaaatcat aagattgaag aatcatgtag 2688481 ctgaattccg tgtacgagat gccggattca attcttgagc tgaccgtatc ttttgccagc 2688541 atgtaattga tgccgaaatt tttaccaacg tcacgaagga aatcgatcac attcattttg 2688601 ccgatccagt caaagttgtt cgcgatgaca gctgggtttt ctgctgcttc aaaatctaga 2688661 aatctggaca gctggttttt gattttttgg gaccattcgg atacgatgtc agcagtgttt 2688721 aatgtacgct ctgctttttt tccgcttgga tcaccgatga ggcccgtcgc gccgcccaca 2688781 agcgcaatcg gatgatgccc tgcaagctga aaacggcgaa gtgttaaaat aggcagcagg 2688841 tgtccgatat gcaagctgtc tgctgtaggg tcaaagcctg agtacaagcg gattttttct 2688901 tcattcagct gtttatttaa cccttcttca tctgtcattt gctgaatcaa tccgcggaag 2688961 gataagtctt caagtaagtt agtcataaga taaagctcct tttttaatta aaataaaaaa 2689021 cgccccttcg tttacacgaa gggacgattg attatcgcgg taccacccta ctaataagag 2689081 aatgcaaaca ttcgtcttat cactttgcct gataacggat caggtccgtt ctttcactac 2689141 tgaaagcctg gccggctttg tttgcaaaag cggttcatga gtgtattcga tatatccgtc 2689201 tgtgctgatt ttcaccggcc atcagctctc tggaacgtaa ggatattcta cttgtctcaa 2689261 tctttacctt ttcatatgaa gctatatcat ttttaacata aataaaatcc tgtgtcaacg 2689321 ccgcctttta atcctccatt gttgacagat ctccagccgg cagattaagc tcccatgcct 2689381 tcagcacgcg cctcatgatc tttccgcttc tggttttcgg aagcttatct ttaaattcga 2689441 tctcacgcgg agccgcatgg gctgcaagac cctgctttac aaataggcgg atctcttctt 2689501 tcagtttatc agacggctca aatccttccc tgagtgcaat aaaggcttta atgatttctc 2689561 cacgcaccgg gtcaggcttt ccgataacgc ctgcttctgc aatagccgga tgttcgacaa 2689621 gcttgctttc cacttcaaat gggccgacgc gctcaccgga ggtcatgatg acgtcatcaa 2689681 ctctgccttg gaaccaaaag tatccctctt catccatgta agcagaatcc ccagacacat 2689741 accagccgcc cggcatgaaa tacgattcat acttttcagg gttattccaa atggtatgca 2689801 tcatggaagg ccagcccttt ttgatggcga gattgcccat tcggtacggc ggtagctcgt 2689861 tgccttgatt gtcaacgatc gctgcctcca ctcctggaat cggcttaccc attgaacccg 2689921 gtttaatatc catgcaagga tagttgcaga tgagctgact gcccgtttcg gtcatccacc 2689981 aggtatcatg gattcgtttg ttaaaaactt tatgtcccca tctgatgact tccggattta 2690041 gcggctcacc gacactgagc acatgccgga gtgaagttag atcatatttc gcagccattt 2690101 catctcccgc tcccatcagc atccgaaaag ctgtcggcgc gctgtaccag acattgacgc 2690161 caagctgttc aatcgttcca taccagcttt ccgggctgaa acgtccgccg acgatgacat 2690221 ttgtcgctcc gttcagccac ggtgcaaaaa tgccgtatac cgtacctgtc acccagcctg 2690281 gatcagccgt gcaccaataa atgtcttctt cctttaaatc aaggacccac tttcctgttt 2690341 gatattgctg aatcatcgct tcatggacat gcaacacgcc ctttggcgta ccagtggaac 2690401 ctgatgtata gtgaagcaga aagccgtctt ttttatccat ccattcgata tccaatcttg 2690461 tgctttcctg tttcgctgct tcatcataat tgatgatatt cgtgccgctc tcagcctctc 2690521 ccccgactac gaagacatgc tgcaagtgag gcagtttgtc taccggtatt ctctccagca 2690581 gctcaggcgt tgtgacaaca acctttgcct cactgttttc aagccggtct ttcaccgctc 2690641 cctccataaa tgcttcgaac agcggcccgg cgatggcgcc aattttgatt gcgccaagca 2690701 taataaaata aagctcgggt gatctcggca taaaaataaa aacgcggtcc cctttttcca 2690761 catttccata ccgtctcagc acattcccgg ctctgtttga ttcttccttc atttctttaa 2690821 atgtgtattt ttcatccctt tttgcgtctt tataataaag cgctactttg ttttttcgaa 2690881 acgattcggc atggcggtca atcgcttcat acgccgcatt cagtttccct gtctcatgcc 2690941 aagagaaatg tttctctgcc tcggcccaat caaaatgccg gtacgtttct tcatagtttt 2691001 ttaagttatg atccccctct attgctggta acgctttcaa gttcatgccc aaacatcccc 2691061 ctttgctgaa gttgtcacaa ttattatagt atatattcat attcttctca atttttaaaa 2691121 tataaaccat gttgaaaacg ctttataatt tggtattctt aaagaaggca tgtatttttg 2691181 ataagaattg atgggacggt gaattagtgg aacatcataa aacataccat tcagcaaaca 2691241 tcaaaacagc aaccggctct ttactgatag aagggcctgt ctctccagag gatttggcag 2691301 gttatgagtt tcataaagat ttaaccgcat ttcgcccgcc tcgcgagcag catgaagcgc 2691361 tagtcgacat tgcaggcctt cccgaagggc gcattattat tgccagagac ggccgaacca 2691421 ttgtcggcta tgtcacgtat ttatatcctg acccgctcga aagatggtct gaaggaaata 2691481 tggaggattt gattgagctc ggagccatcg aagtagcgcc ggactatcgg ggatgcgctg 2691541 tcggaaagac gctcctgacc gtcagcatga tggatgaaca aatggaaaac tacattgtga 2691601 tgacgacaga atattactgg cattgggatt taaaagggat gaaaaaagat gtgtgggaat 2691661 acagaaagat catggaaaag atgatgaatg caggcggatt ggtctggttt gcaacggatg 2691721 agccggagat cagctcccac cctgcaaact gtctgatggc ccgcattgga aaaaacgtca 2691781 gccaagaatc aattgagcaa tttgacaggc tccgttttta tcatcgttat atgtattaac 2691841 tgacactgac aaaggggaaa aaataatgat tgttgagcaa atcatgaaaa gagatgtcat 2691901 tacattaacg aagacggata cgcttgaaac agcaatatgc aaactgaagg aattccatat 2691961 caggcatctg cctgttgtag atgaagaacg acacgtgatc ggcatgatta cagacaggga 2692021 catgaaacag gccagcccga gtatttttga agaaaacaaa cgaagcctat ttctcacacg 2692081 aagcgtagat tcaattatga aaaaggatgt tgtctgcgcc cacccgttag attttgtcga 2692141 agaaatatca gccgtgttct acgagcatgg catcggctgc ctaccagtgg tacaccatca 2692201 aaaattaata ggcattttaa caaaaaccga tttgctgcgg acgtttgtca aattgacagg 2692261 cgctgaccag ccgggctcgc aaattgagat aaaagtaaac gacatcacca aaagcctcgc 2692321 tgagatcagc agtctttgcc aagaccttca agtgaaaata ttaagcgtgc ttgtttatcc 2692381 gcatgacgat cccggtgtaa aagtgcttgt cttccgtgta aaaacgatga atccgctgcc 2692441 gtttttgcag gcattacaaa gaaatggaca ccacgtcgta tggccgtcag agcaaaggga 2692501 tctgctatga gagacagtgt atttatctat tctccatcct accaaaccta tatgtttcat 2692561 caggagcatc cctttaatca gcagcgggtt ctgttaacat atgatttgct taagacgatc 2692621 aatgcctttg atgatggaga cattgtcacc cccagactcg cttcagaaga ggagctttcc 2692681 cttgtccaca cggacgatta cattcaggcc gtaaagcttg cgggcgccgg aaagctcccc 2692741 gctgaagaag gagaaagcta cgggctcggc actgaagaca cacccgtctt tgccggcatg 2692801 cacgaagcgg catcactctt ggtcggcggc actttaacgg ccgcagactg ggtcatgtca 2692861 ggacaagccc tgcatgcggc aaaccttggc ggagggcttc atcacggctt tcgcgggaga 2692921 gcatcaggat tctgcatata caacgacagc gctgtggcta ttcaatatat ccagaaaaaa 2692981 tatagcgcca gagtgcttta tattgatacg gacgcccacc acggggacgg tgtgcaattt 2693041 acattttacg ataatcctga cgtatgcacg ctgtccattc atgaaacagg aaggtattta 2693101 ttccctggaa ccggtcagat ccaagaaaaa ggaagcggaa aaggatatgg ctattccttt 2693161 aatattccgc ttgacgcttt tacagaggat gattcttttc ttgaggctta ccggacagca 2693221 gcttcagaag tcgccgcgta tttcgagccc gatgtcatta tcagccaaaa cggcgccgat 2693281 gcccattact acgacccgct gacgcattta tcagcaacaa tcaatatata cgaagaaatc 2693341 ccccgtcttg cacacacttt ggctcatcaa tattgcggag ggaaatggat tgcagtcgga 2693401 ggcggcggat atgatatttg gcgtgtcgtg ccccgcgcct gggccagaat atggcttgaa 2693461 atgaagggaa ttgacccggg tcacgagatc ccgccggaat ggattgttaa atggcaaaaa 2693521 caatgccccg tggcccttcc gtcgagctgg agcgatccgg ctgatttata tcctccgatt 2693581 ccccgcaagc ctgaaattac agaaaaaaat gcccaaactg tcagcaaagc attatatgcg 2693641 atacgttctg aacagcaaag aacaaagtaa aaaacgacct ttacgaagag gtcgtttttg 2693701 attttttaat cactatttcc acacgccgat tttccttcat gtgttcattt gtcttgttat 2693761 cctttactgg ctttgtatcc gcataaccga cagcaataaa gcgcttggag ggaagcttct 2693821 ctttagacgt gaagtattga atcactccac ttgcccgtgc tgctgatagc tcccagttcg 2693881 acgggtatcg gtatgtcgaa atgtttcggc tgtctgtatg tccctcaacc tgaatgtcat 2693941 ttggaattgt ttgaagaaga acggcaattt ggtgaagaag tgtttcggca tttttcagca 2694001 cctttgcctc acctgtatca aacagcacag cctcctgaag aacgagcacg acaccgcgtt 2694061 catcccgttt ggctgtcatt tgggccttca aatgattgtc ttttatatat gtatttactt 2694121 tcttgagaag ctgatcctgc tgatcctctt gcttcttcgt atcagatggg gatgtattct 2694181 ttttttctat ggatgtttgg tccggctgaa gcccgttgcc ttccttctgg atcgagtcca 2694241 ctgccgcttt gaatttttgc agatcgattt gggacatcga aaagagtaaa ataaagaaca 2694301 caaggatcaa ggtgatcaga tctgtaaagg ttaccatcca gctggatgaa gattgactgt 2694361 tttttccgct tccattcctt ctttcaaaac gttctcttct aagcttcatg tacagatccc 2694421 ttttttgttt ttacttgttt tggctgcttc tgccattctt cccgtgagct gaaaacgacc 2694481 agctggcttt caaggttgcg cgggtttttt ccggattgaa caccgataat cccttccacc 2694541 attacctgct tgatgaaaat ttcactttct gttttctctt caagcttagc cgcgatcggg 2694601 ttgaagacca tatttgccag taatgaacca tataaagtcg tcagaagcgc aatggccatg 2694661 tttggtccga gcatatgcgg gtcgtttaag tttttgagca tcagcacaag cccgacgagt 2694721 gttccgatca ttccccatgc cggagcgaat tctcccgctt tttcaaaaac tcgccgccct 2694781 tttcggtgcc gttcctccat tgctgcgatt tctgaatcca tgacgagccg aatcgtttct 2694841 tcatcccagc cgtcaatcgc taaaagcagc ccttttttca agaatggatc tttgatttcc 2694901 cgagcctgat catccaatga taaaagcccg tgttttcgcg cgtgatcgga aagggaaaca 2694961 aaggttttca caagatcttt cacattgtct tcctggcgga tgaatgcctg ctttaacaca 2695021 gagggcgctt ttttcagctc acttggcgga aaactgataa aaacagcggc gcaaagtccc 2695081 cctgttacga tgaagaaaga ggtcagatca agaaaagagc ggaaaccgct tactcccgat 2695141 cctgaaataa tcccgataac aataataatc gttcctaaca caaatccaac aggtgtaaga 2695201 taatcaaaac gtttcatcat ttctccccat gaaaaaagca agaattcacc ataaaggtga 2695261 agcttgctct ttgtttttct tatgacttgg ttgactttct aagctctata cggtgcggca 2695321 gttcgacgat atgctcttca accggctctt tattcatgag cttcgtcagc agtctcatcg 2695381 caacggcgcc gatatcatat gtcggctgaa caactgttga aagctgagga cgaaccatga 2695441 ggcttaatct tgtattatca aaaccgataa tgtcgagatc ctccggaatg gataagccct 2695501 gatcctgagc ggcatggata atgccgagtg ccatttcatc agttgcagaa agaatggctg 2695561 tcggtttttt atccaggctc atcagatgct gcagtgcttc gagtccggaa tcatatgtgt 2695621 aatccccttc agctacaaat tgttcattaa acggaaggtt cgcttcttca agcgcacgtt 2695681 tgtagccttg gagttttttc gaacggttga tcggttctgc cattggtccg gaaacgaacg 2695741 cgatgtctgt atgtccttta tcaaccaaaa gcttcacggc atcataaatc gcctgttcgt 2695801 aatcgatagc gactgacggt gtttcctcct gctcttctac agaagcggca agtacaatcg 2695861 gcactggaga acgcttaaat tccgccacat gctcgtccgt aatgtttccg cccataaaca 2695921 cgatgccgtc cacttgtttg ccgagcattg tgtttaacaa gtgcagctct ttctccatgt 2695981 tttggtcaga gttgctcaaa ataatattgt atttatacat tgtcgcgata tcttcaattc 2696041 cgcgcgcaag ctctgaatag aaaatgcttg agatatcggg aatgatgaca cctacagttg 2696101 ttgttttttt acttgccagc cctcttgcca ccgcgtttgg acggtaaccg agacgttcaa 2696161 tggcttccaa gacttttttc ctcgttgtcg gttttacatt cgggttgccg ttcacgacac 2696221 gggaaacggt tgccatgctt acattagctt ctctcgctac atcgtagatc gtaatattgc 2696281 tcatcctaaa accactcctt ttactggata cacttatcct tatctatagc ataaacactt 2696341 tatgtagaga aatgtcataa tgtccgaatt tatgtcgttt atgatttgta agcgtaagtc 2696401 agtagtgtac attatttttc attattcatc aaatttaatt acttctcatg aaattataca 2696461 cgtttttata gatgatgaaa acgtatactt ggtttttata actaaataaa cgagaaagca 2696521 taaaaaaagg ccgcaggcgc ggccttttgg attgttcaat taagcgttga ctttcaccat 2696581 tggcttcagt tcattcagcc atttttcgaa ttcaggaatc gccatttgct gagcagagtc 2696641 agaaagtgcg actgacggat cagggtgaac ctcagccatt acgccatcag caccgatcgc 2696701 taaagcggct ttagctgtcg gaagcaagag gtcacggcgg cctgttgaat gcgtaacatc 2696761 aacaaagact ggcaaatgcg tttcttgttt caaaatcggc acagctgaaa tatccagcgt 2696821 gtttctcgtt gctgtttcat atgttctgat tccgcgctca caaaggataa tttggtcatt 2696881 tccttgtgac atgatgtatt cagcagcatt gatgaattca gagatcgttg cagcaagacc 2696941 gcgcttcaga agcactggct ttttcacggc gccggccgct ttcagcaatt cgaagttttg 2697001 catgttgcgc gctccgattt gaatgacatc aatgtagtcc agcgcttctt cgatatgagc 2697061 cggagttacg atttcactga taaccgccag atcaaattca tccgctacac gttttaaaat 2697121 ttgaaggcct tcaacaccaa gcccttggaa atcgtatggg ctcgtacgag gcttaaaggc 2697181 tccaccgcgc aaaattttaa tcccttgttt tttcgcagct gcagcgactt cagctacctg 2697241 ctcatagctc tctaccgcac atgggccgac aatgaatctt tgctggccgt ctccgatttt 2697301 ttcgcctttg atatcaacaa ttgtatcttc aggttttttc ttgcgggaga caagcagcgc 2697361 tttgctgtga tcttcttcct gaagctctaa accggctttg aatatctctt taaaaatgtg 2697421 ctggatggtt gaattttcga acggcccgtc attgttttca atgatattgt ttaacattgt 2697481 gcgttctctg acagggtcaa atcggttgac accctgtgct tccttcgctt taccgatctc 2697541 ttttacaaca ttgccgcgtt cgttgattaa ttttaaaatt tgtaggttta attcgtctgc 2697601 tttctgcctt aaaagctcta actctgtgtt gctcattttt ttcatccttt ccctgcacat 2697661 tcatttttta ttttgtagtt atcatgcatc ttactataag taattccaaa tggaaatact 2697721 gaaatacaaa aaattttata aaaactctac tttattaccc aaacgctttt aagtgataaa 2697781 gtaatctatg aagctatcct acatgatgtg agggcaatgt tcaagggttt tttacaaaaa 2697841 aaagcgccag atgatatctg gacgcttttt tctatgacaa atgctgctca atagcggctt 2697901 ctgtaatttg tgaatgtgag gtatgccatt tcacttcacc gttctggatg atgaatatct 2697961 gagggctttc atgcttgacc ccatatgttt ctgcaatgaa attggacagc ggccgggctt 2698021 cttgtacttg aagatagtaa gccggcacat cctcatgctg atttgcaaag gcatcaaact 2698081 catgaaatgc tgcctggctg atcgggcatg tggtgctgtg tttcaagaag acgaaaacgc 2698141 cttcctgttc tgcaatccgt ttaaattctt cctcagattg aataagctgt ttagccatga 2698201 ctcaagctct tccttccctg ctcagcgatt caactgctca gcctgttttt gtgcatcttt 2698261 cagttcgtct tttacatctt ctttcgtctg gaggacttga tcttttgttt catcagctgc 2698321 ctgcatcgct tcttccctca tatcttgcat tgcagtcgat gaatccgttt tgtcagattt 2698381 ggaacggtct ctcaaatcct ttaccttgtt catgatctgt ccagactgat ccgctacaag 2698441 ctgtgtgatg ttggaagttt tgtcttttgc gatgctgaca tattgcgtgc ctttttcctt 2698501 cgcatctgcc gtcattttat cagttttgtc ccgtaaggca acagcctggc tgccgagatc 2698561 gtcgcgaagt tctttgcctg atttaggcgc tagaaaaaga gctgtagtgg caccgatgat 2698621 tcccccgatt aaagttccga ttaaaaaatc tttactatta attccatctt tgctcatcat 2698681 tattcctcct cttagtattt ttttctctta cagggctgat tttttctttt gcttccattt 2698741 ctcccaaatt tccattgctg cttgactcca agtgacaact tgattgatct tatcttgatt 2698801 ctctctaact gatgccgata cagaccctgc cgcttgtttc atggatgtat tgaactgctg 2698861 tacagaagct cccactcctt gaacagcatg aacgaccgtg ttcagctttt ctgatttttc 2698921 ctgaatatct tcagccaggc ggttggtctt atgtaaaagc tcggctgttt cagttgtgat 2698981 gcccttcatt tgtccctcca gcccttcaag agtggatgcg acgtttttta gtgtcagctg 2699041 cagtgacttc aatgttttag acaagtagat cactaatacg agaaatgcaa ctgcgatgag 2699101 tgcaacgctc aaataaagaa taataatcat ctcaaacctc cttgctgcag gatatactgc 2699161 tgtttacccg ttttcttcaa tcataaacat gtgtactggg ctgtatacat actattctcc 2699221 gttatgtaag aaaatccttt aataagcttt cccatcagat aaataaaaag cagtgagatc 2699281 actgcttttt attatgccat gacgttttcg taggctctca tatatttttg gatatctcct 2699341 gctcccatga agatgagaac ggctttatca tgagctttta aaacagatgt gtcatcttct 2699401 tcaatcagct tggcattatg aatttttccc tggagatcac cgatcgtcag ctttccggca 2699461 ttctcacggg ctgagccgaa aatatcgcat aaatacacac agtcggcgcc gctcaggctt 2699521 tctgcaaatt cgtcaaggaa ctgctgcgtc cgggtaaatg tatgaggctg gaataccgcg 2699581 acaatttccc gatcaggata cttctgtctt gccgcctcga ttgtcacttt tatttctgtc 2699641 ggatgatggg catagtcatc aatcagcact tgatccccaa gctgcttctc attgaatctg 2699701 cgtttgacgc ccccaaagga tttgagagca tgcttaatga tgctggaatc aatttcttca 2699761 taatggcata acgcaatgac cgccaatgag tttaatacat tgtggtggcc gtacgcagga 2699821 atataaaacg tatcatagaa cgtattgcgg acaaagacat caaaagttgt cccttccgtg 2699881 ctttttacga tgtttctggc ttgaaaatca ttttcttccc ccgtgccata atacacaacc 2699941 gggacgttcg catggatttt cggcagatgc tcatcgtctc cgcaggcaat aatgcctttg 2700001 ttgacttgaa gagccatctc ttggaaagcg tcaaatacat cgtcaatgct tgagaagtaa 2700061 tcagggtgat caaaatcaat attcgtcata atcgcataat ctggctgata gcttaagaaa 2700121 tggcggcggt attcgcacgc ttcaaacaca aagtattcgc tgttttcatt tccctggcct 2700181 gttccgtctc cgattaagaa agacgtcggt tttgcgtttt ggatcacgtg agccagcaga 2700241 cccgtagtcg acgttttgcc gtgtgcgccc gtaacggcaa cactcgtgaa ttttttcatg 2700301 tagtcgccta aaaacttatg ataacgtatc accggaattc cctcagacat cgctttttct 2700361 atttcaggat gcgtgtctgg gaatgcgttt ccggcgatga ctgtcatgcc gggtttaata 2700421 ttttccgcgc taaaaggaag aatcgtaata tttctttttt caagcgctgt ttgcgtaaaa 2700481 ataaattttt cgatatccga tccttggaca gtatatccat tatcatgaag tatttgggca 2700541 agcggactca taccggtccc ttttattcca acaaaatgat aaacagtcat aattgtacct 2700601 ccaacaaacg tctatctgtt ccccagtata tgacgctcat ttcaatttgc gaccgcggcg 2700661 gctgaaaagc ctcccttagc ggcgtatttt atatgttttg ttatgtttag tatcaggtta 2700721 tttctttccg attaaaccca gatatcaaga tttgtctatg cacagctgct gtaaagcggc 2700781 atagctgtta aatgctctaa acactatcat accatgtttg gtgtgaaaat gaacccatat 2700841 tattcgttta ttaaatcact tgctgtgatc agcacctctc gaggcttgct tccttttgcc 2700901 tcagagatca tgccttccgc ttccatcatg tcgatcagcc ttgccgcacg attgtaaccg 2700961 attctgaatc ttctttgcag gcttgaagtg ctcgcactgt tttgctctac aacaaactca 2701021 cacgcttcgt aaaacagttc gtcctcttct ttcagggcag atccttgtct tacgagctct 2701081 tcttgttcaa ataaataggt cggcggcatt tggcttctga cgtgggaaac gacgcggtcg 2701141 atttcccggt ctgacacaaa gttaccttgc agacgaaccg gttttcccga gccgttttcc 2701201 aaaaagagca tatccccttt tccgagaagc ttttctgcac cggctatatc aataattgtt 2701261 cgggaatcaa cctggcttga gacagaaaag gcgattctcg ttgggatatt cgccttaatc 2701321 agacctgtaa tgacatcgac tgacggacgc tgagttgcga cgagaagatg gataccgcac 2701381 gctctggctt tttgggcgat ccgcgcaatg ctttcttcca catcgtttgg agccaccatc 2701441 atcaaatctg caagctcatc aataatgaca actaaatacg gcagcttttc acccatttgg 2701501 tgttcagcgg ttaattgatt aaagcggtca atgtcgcgga cacctgaatg ggcaaaaagc 2701561 tcatagcggc gctccatttc ctcaacgacc catttcaaag cagccgtagc cgctttagca 2701621 tcagtaatga ccgggctgac gaggtgagga attttattgt aaggggccag ctctaccatt 2701681 ttcggatcaa tcagcagcac ctttacctca ctcgggtcag ctttataaag caggcttact 2701741 aatattgtat tgatgcatac gctttttccg gagcctgtag cgccggcaat caagccatgc 2701801 ggcattttct tcaagtcgat aacaacagga tttcccgaaa tatctaatcc cagcgcagct 2701861 gtgagcggtg acttgcttgt cctgaaagct gagctgcgaa tcatttggcg caaatcaacc 2701921 accttgctcg tgcggttcgg cacttcaatt ccgatcgtgt ttttccccgg aatcggcgct 2701981 tcaatccgaa tatctttagc tgagagactg agtttaatat catcggacaa gttggtgatt 2702041 ttattcacct ttacacccgg ttcaggatgc acttcaaatc tcgtgacaga cggaccctgg 2702101 gttacatgga ccacattggc gcggacattg aaatttttca aggtcaaatc aagaagctga 2702161 cgctgttctt cgatccacgc agtatcatct tgaacctgcg ctggcgggac atcaagcagt 2702221 gcaacattcg gaaatacata gctgccgcgg cgctcctctg ctttttgctg tttatgcgta 2702281 tctcttttca gcatcatcac attaaaagga acggatggcc ctttttgaga agatgcgctt 2702341 tgttcagtcc ttttctcctg tacaccaggc ctttttttcg gctcttctga agcttcgcga 2702401 ggtttgtctg cgcgaatttc ctgccggttt tcaagagttg cagtagacga tttggaaccc 2702461 tgctccatgt gttcagtttt ctcaagctct gtatggctgt ctggctgaac atctatcttc 2702521 gtttcctgag cctctcccag ggtgtcataa tgattattta ttatgctttc tgatggctct 2702581 tctgattctt ttgccacagt ttctgcttga gccagagcct ctgatgaata ctcatgatca 2702641 gtaaataaag gctcttcctg acgaatgtcc atttgttctt cttgaacgaa cggggactca 2702701 gcaccttctg ccgcgttttc atgatgattg tatactgggc tgtctgacgg ctcttttgct 2702761 ttttcatcct cagatactgc ctctgtctga gattcaggag ctgtttgctc ttcatcaagt 2702821 tcagcggaga aaacaggctc ttcaaatttc tctggctgct gctccctttg ttcttcctca 2702881 gccgttgcag gctcttcgcg gcctacttca ctgtctgaaa gcccttcagc cgccgtatct 2702941 gtgagcatct caggcggtgt ttgctcttcg gcttgttcag ctgggaagaa aggctcctct 2703001 ttttccggct gttgaacgcc tgactcaaat ggcactttgt tacctgacgg ctcggctggc 2703061 cgtttcgcca gcgcctcatc atgctccgta tcctttctgt ttaaaacgcc agaaggctgt 2703121 ttttcaaatt gggtatccgg gaagaaagga ctttctattt tggaatgcgc ctgtgtgtct 2703181 gaagcaggat agccgcgttc acgttcgatc tcttctgaca gcagtgttac cttctctttt 2703241 accgatttat ccggttcgtt caatgtttca gaaggctttt tcggcacatc ctttttaaca 2703301 gatggttttt gattgaatcc atagacaggc gaagggatat ttgtcggttt aaacggtttc 2703361 ttcgccggct ctgctgcttg atatgtatgc tgctcttctt catttctggg acgctctctg 2703421 taaggtgcag cacttggacg aggcgcggat ttcggttcgt ccgatggtgt gcggcgcctt 2703481 ctcaggtcat gatttttgta tccgtcaggc acgactggaa aacggaattt gccttttgga 2703541 tattcataat atattttagg atcttccaat ctttttaatt gtccttcagg atgatgtact 2703601 tcttgttgct gcggaatttg agcgggtttt gtctcccgtt cagcatcctc ttcgctttcg 2703661 cctaaaaaca aatcaaaaaa tttatgaagc caactcataa tttatctcta actcccttat 2703721 agttttctgg gacggttttt agtataccac tgctggtcgg cccagaaaag attaagctat 2703781 cagcagaaac aaagccgcta aacaagggct tagcggcttt tcacatgatt cgtttttttt 2703841 ggcggattta tgggagtcta aaactgaaat gcgtctcccg cctcatagtc tccttctaac 2703901 acaaggattc ctttttcagc aggggcatcc ggcaaatcaa gctctttcgc tgagcagatc 2703961 atcccgcttg acggaacgcc acgaagctct gcatccttaa tgacaagtcc gctaggcatc 2704021 acagcaccga ctttggcaac gacaactttt tggccttggt caacgttagg cgcgccgcag 2704081 acgatctgaa gcgtttcttc tcctacgttg actttacata cgcttaattt atccgcattc 2704141 ggatgttttt cttttgattc tacataaccc acaacaaact tcggagataa atcaacgact 2704201 aatgtttctt caacgccgtt tctgtttaaa atctcattca catcttgcac gaatgtttct 2704261 gagagcgcaa cagggccgtt ttcatcaatg gtcaagtaag aagacgcatt gaaaatgttg 2704321 aagcccgttg tttcttttgt ttcgttattg aaaattttga cgacgtcgcc gtgtttttca 2704381 tagcctaatt gttcgcgtgt cacatcttga agagagatca ggagcgtgtc tcccacacct 2704441 tctttattat aaaaagcgtt cataagtaaa aatcctttct aatccttttt cggacggctt 2704501 ttcgccagga taaacaccgg ttccagcttt ccttcattgt acaaaaatga tagggcggta 2704561 atcgggacgg tgccgcctgc aaagaagctc atcgacattt gtcctagaat atcatacccc 2704621 gattcattcc ggatgtcagc aagaatcaaa acgtcctgat gaggaacaga gatcgccagc 2704681 tcaccttctg catgctgctt atactcattt aagatcgctt cgttcaaaat ccggcttgcg 2704741 tcgtatccgt cgtttgccct gaagaaataa aagtaattgc cggcaaccgt atcctctttg 2704801 acaaccgtcg gcagggaacg gagattaaat gcggccgtct ctctgatccg ctcttttgtc 2704861 cagttttctt tctcaagcat gcgctggtca attaaacggt aggttttccc gagatctagc 2704921 gcgtaataaa ttcttgtctc tgcggtatga tcgtcataaa tgagcgggat atcttcgctg 2704981 gacttgtccg ggaaggaagt cgagcggatg accggataaa tgcgagtttc tttcccggtc 2705041 atttcctgag ccttcccttc cattgccgtc atcgcttcgg agacatagta cacgatctca 2705101 tcaatggctt cgtctttttt cagttcccat tttgcaataa tcggcggcaa atcgagtgta 2705161 atcccttttt tagtcgtttg atcctcaaca cggagggtgt ctttttctct gtcaaacaga 2705221 aaggagcgat tctcgtgctg aaggcgctgc ttcagtatat ctgacagctt ccttgaggtc 2705281 attttcaaac cgatgtcctc ctttacgctt tagcgagaga gtctgttaaa aactgttcaa 2705341 tttcttcttt tgttttgcgg tctttgctca caaaacgatt tacttctttt ccttcattaa 2705401 acaccacaaa gcttgggatt ccgtaaattt cccactctgc acatgtatca atgaatttgt 2705461 cacggtctac gtagtagtag gtgaattcag ggaaattcgc ttccagttca ggcaggaaag 2705521 gctctacaaa acggcaatcc gggcaccaat cggccgaaaa cataaataca gaccaatcat 2705581 cctttaccgc tttttccagc tcttgagttg attcaatttt tttcatttca tatccctcca 2705641 gttgtttatg ttcttacatg ttttttatcg atactcgtcc atttggatca taccaaactg 2705701 cttgaggcaa aaccacttat atgcaacgaa tgaatatgta agattggctt tcccattatc 2705761 attatcatat tttatttgca ttatcaagct cgtttcgttt aacatcgtgt acatgagggt 2705821 gaaatttaca gatggatata cataaggagg gatttttatt atggagttta tcgtctattt 2705881 agcaggagaa atccacagca attggcgcga ggaaattaaa gaaaaaacaa aatcactgaa 2705941 gctcccgatt acgtttgttg gcccgatgga gaatcatgac cgctcagaca atattggtga 2706001 agaaattatg ggcgtacagc caaatgccgt tttaaaggat gacaaagcct ctgacatcaa 2706061 caacttcaga accgccgtcc tgatgaataa agcagacttt gtgatcgccc tgtttggcga 2706121 aaagtacaaa cagtggaaca cggcaatgga tgcatcatat gcgatcgcaa aaggaaaacc 2706181 cctgattatc atccggccgg aatcgctcca ccatccttta aaagagcttt ccaataaagc 2706241 gaatattacg gttgaaaccg ttaaccaagc cattaaggcc ctttcctatc tatttgaaac 2706301 agaataagaa aaaagcttgt cgatccgggc ttactgctcg ttcaacaagc ttttatgaaa 2706361 cctacatatt ttctttaatc gcatccactg tctgcttatc gcaggctgtt acaagtttga 2706421 tgagcatttc tttagcagca gcataatcat caatatgaat gatagtagcg tttgtatgaa 2706481 tatagcggga acatattccg ataaccgctg acggcacacc gctgttcgaa atatgaacct 2706541 tgcctgcgtc tgttcccccg ccggatacaa aatattgata tggaatatca tgcgtttcag 2706601 ccatatcaag aacgaattcc ctcattccgc gatgcatgac tgtcgttctg tcaagaatgc 2706661 gcagcaaaaa gccttttcca agctggccga attcattttt gtctccgctc atatcgtttg 2706721 ccgggctggc gtcaagggcg aaaaacaagt ccggtttaat catatgagaa gccgtctgcg 2706781 cgccccttag ccctacttct tcctgaaccg ttgcacccgc atagagtgta ttcggaagct 2706841 ctttaccgtg taattccttc agaagttcaa tgcttaagcc gcatccatat ctgttatccc 2706901 atgcttttga taaaattttc ttttcattcg ccatcgtcgt aaacggacaa acaggcacga 2706961 tctgctgtcc cggtctaatg ccgattttga tggcgtcttc cttatcatcc gctccaatgt 2707021 cgatcatcat gtttttgata tccatcggtc ggtttcgctg cgcatctgtc aataaatgcg 2707081 gcggtatgct tgaaatcaca cccggaaccg gcccgttatc tgtttgaatt tcaacccgct 2707141 gcgcaagcaa aacttggctc caccagcctc cgagcgtctg gaatctgagc agcccgttgt 2707201 ctgtaatgga tgtcaccatg aagccgactt cgtccatgtg cccggctacc ataattctcg 2707261 gtgcgtcctc tgcgcctcgt ctgactccga aaacacttcc cagtctgtcc tgaacgatgt 2707321 catctgcata tttggctagc tcctgcttca taaaagcacg aacctgatgc tcattgcccg 2707381 gcgcgccggg aagctgcgtc agtgtttgga aaagcgcttt cgtttcttga ttcatgtttt 2707441 cccctcattt ctatgtagtc cttttatttt attagaaaca atgaagtttt ccaagcactc 2707501 tgacccaatc tgctcgatca gccgcgtatt gcttaacagg atttggctgt ttctgtataa 2707561 tgaaaagtac gatcaaccag gaggtgcttt attttgaaat tgcgtcatct tcttttagga 2707621 gcaggacttg gaatttgtac ggctgtcgtt gtgagacaat atgtgatgaa gccttatatt 2707681 tcttcagaaa aagcgcttcg aattgtaaaa tctgctttta agcagcgggg cccgattgac 2707741 ggatcatgga tttacaccca gccggagccc tacaatatta acggagaaac ggtacaggta 2707801 tacaaaaccg gcattacacg atcagctttc ggagaattag aacagtatga agtcatggtg 2707861 gatgcgaaaa cgggagaaat tgttgatgtc attgatacaa tcgcctctta acaccggaca 2707921 agcaaaaaat agaagccgct gcctatgcag cggctctttt ttattatatc gcgcgaatcg 2707981 gtttgtatac cggataccac atcgcatcct gcactgcctg tataatgtct tcaggctctt 2708041 ccgtagcgac gccttccttc attgcggttt ttgcaacttc aacagcaacg gttgccgaaa 2708101 cagtgcgcaa atcttcaact tttggaagca tcggcgcccc aggcaccccg acattgacca 2708161 tacctgcgat tgcccgggca catgcttcaa acatgccgtc ggtaattaat tttgattttg 2708221 taacaatcgt tccaagaccg agaccaggga agacaagcgc gttgtttgcc tgcccgatat 2708281 gatacgtaac tccgttatat tcaactggcg ggaacgggct tcctgtcgtg atcagcgcac 2708341 ggccttctgt ccattcgatt aaatcctccg gctttgcttc agaaagagtt gtcggatttg 2708401 acattggcaa aatcgccggc cgtttcacat gtgacgccat ttcttttaca atttcttcag 2708461 tgaaagcgcc ggaaaccgta gatgtgccga tcaggatcgt cggtttcgcc tgccgaacca 2708521 cttcaagaag atcaatgcct ccgccgtctc cgttccgctg ataatccttc acttcatcag 2708581 ccgaacgggc atacggcttt tggaaatcaa gaagctgatc catatcatct gttaacagcc 2708641 cgttcctgtc tatgcaccag aagcgcttgt atgattcttc ttcactcagt ccctcgcgca 2708701 ccaatgcttc ccgcagctgt tcggcaattc cgattcctgc cgttcccgct ccgaatataa 2708761 caactctgtg atctctcagc ggaactttag acgcttttgc acaggataag actgcggcca 2708821 aagaaacagc gccagttcct tggatatcat cattgaaggt acacacttta tctttatagc 2708881 gtttcaaaat gcttcgcgcg tttttcgccc cgaaatcctc ccaatgcagc aatgcattcg 2708941 gaaatgtttc tctcgccagc gcaacgtagt cgtcaataaa ttggtcataa cgttccccgc 2709001 gcactctgga atgctggttg ccgacataaa gcgggtcgtt caagaggctc tcctgatttg 2709061 tccccgcatc taaaacaaca gccagcactc tgctcggatc aatgcccgca gccgctgtat 2709121 aaaccgccag cttgccaata gaaattgcga ttcctccgac gccccagtca ccgattccta 2709181 aaattccttc cgcatcagtt gcaacaatta aatcgatcgt atcgctttga tctttatact 2709241 gtttaaaagc ttctttcata ccgtccgggt catcgattga cagatagagc cctcgtggtt 2709301 ttctgtattc atggctgtat ctctgaattg ccgttccgac tgtcggtgtg tagacaatcg 2709361 ggagcatttc ccctaaatgg tcatttaaca ggcggtaaaa cagcgtttca ttccgatcgt 2709421 gcagcgccgt taaatagaca tttttgctca aatcgtcagg ctgtgcggaa tattgttcat 2709481 acgctctttt cgcctgatca tcaattgtta ataccttggg cggcagaaag ccttttaaac 2709541 caagttcttt tctttcttcc tcagtaaaag caacaccttt gttcaaaaaa ggaacagaga 2709601 gcacttcaag gcctcttaat gttgtttgaa tgtctccttc gtttgttact ctgaattgtt 2709661 tcaccctgcc tcttcctttc tgagcataat agtactaggt ttgcattatt agccggaaaa 2709721 catgcagggt aaacataaaa atatgctatc gcttcattcg cttaactgac tttttgatgc 2709781 ttccgtcctc ctcccattga agggcgcgat actcggcatc atggtaaaaa ataaaccaag 2709841 catctttttc tgctgcgaac gcctgccatt tctgcttttg cgggatagag gtcatcggat 2709901 aatcatcgta agccagcacc catagcggat tgcggtgggc atgtgtcggc atcagatctg 2709961 ccatatgtac ggcagtttca cccgcatcct cgcatatcag gacactgtgt ccgtcgctat 2710021 ggcctccggt gtgatgcatt gtaataccct ctgtgatcgt taaggtgtct tcaaaggttt 2710081 tgacttggcc agctacagcc tcccaatttt ctttccaata cgtatttttc gacctgatat 2710141 tcggatggcg catttcgtcc cattcaacag ctgatgtata aatcactgca ttcggaaaga 2710201 cagagacgag ccgttcacct tcatattccg ttaaaccgca tgcatgatca aaatgaaggt 2710261 gtgtcattgc gatcacatct atatcggcaa ccgttaatcc gagtgcagct aatgagggtt 2710321 tcacattcga ctcttgtgtc acgccatagt ttcgtttttg tttatcagtc agcttgccgt 2710381 acccaattcc ggcgtcaatg atgatattga gcccatcctt ttgaatcaaa atagggtctg 2710441 ttcttagttc aatctggttt ttttcattga ctggatattt tttagaccaa agcggctttg 2710501 gcacaacgcc gaacatggcg cctccgtcca tatgcgtcac gcctccgtca agccaggtca 2710561 acgtgatgtt tccaattttc attgtttcca ttttcacccc cccctatcat catggtagca 2710621 aacggcccat aaaaaaaaca gactcctgtc agagtctgtc tttacgttct ccattcaacc 2710681 tcagcccgat agatcggctg gccgagtgca gagaattttt cttcatattc tgtcataata 2710741 ttgccttcca gattgctgtt atgcaaatcg agactgacgt atgtcagcag gaggccgtac 2710801 tcagagaagc tcttcaaaga gtactcaaat aaacctcggt tgtccgtttt aaaatgaatc 2710861 gatccgcctt tgcccattac ttcttcatat tttttgagga agtgggaata tgtcaggcgg 2710921 cgtttttcat gccgtttctt cggccaagga tcagaaaagt tcaagtagac ccgtttcact 2710981 tcccccggct caaacacatc cgtcagcgtg tccgcatcta tattcagaag ctttacattc 2711041 tgcgcttcgc tgtcttttac tttttggacg gctgtcacga tgacgctttt aaataactca 2711101 ataccaatat aattgatgtc gggattttgt ttggccatac cagaaataaa ttggcctttt 2711161 cctgtaccaa cctcgatatg gatcggattg tcgttgccaa acactgtgtt ccatttccct 2711221 ttataatcag caggattgct gatggcaata tctgcgtttt cagccaaaaa gtcatcagcc 2711281 caaggcttgt ggcgcattct catatgattg acacctctat ctattatttc gactaacaac 2711341 ataccatgaa ttaaaaagac ccgcaagctc gtttttccag tgtatctctc ttaaggccga 2711401 gcgcataaaa aaagagggtc ccgtctgctg gaacactcct ttcccatgta taaaaacgct 2711461 ctgttttgaa caatttaacc cgtatgatac tgaagggatg tgtaccgtta tgggtttaca 2711521 ttatgagcat caagttcatt tattgaagga tatattgact gaccatcaat tggactgctg 2711581 cggaacagtc gcagagtacg agcagcttga gcgtgtgatt aaatcactga tggcaaacac 2711641 cgagcttgat tcaaatttca aaaacgtgct tgaagatgtt taccgctaca gccaatcagg 2711701 aatatcgtcc aaatccatcg actcacacat acaagagcat cagaacagcc tgtctcaatg 2711761 ggtagagcaa atggattcgt attcctgatt aatcaacaat tcgtttcatg aggatatgca 2711821 gctcttccat tgcatcatga aattccttat cattgccttt tgctttatgc caggcaatga 2711881 aagtaattgt ttcagataac acataccaag ccattcgcaa ccgaaggctt tctgtcagct 2711941 ctatgccgta catgctcagc cagctctccc aagctggctt ttcgacgtag tggtacagca 2712001 aaggcccgag gtccatcgcc ggatcagcga tcatggcgcc gtcccagtca attaaataca 2712061 gctggttgtc ttcagacaat agccagttat tatgattgac atcacaatgg caaacgactt 2712121 tctcaccgaa atgcacttca tgcaggtgtt cttccaaata cttgatccct tcttgaatca 2712181 gcggcgaaga ttgctgcaca gcaaatacag cctgcttcag ctgagacaaa agagcccccg 2712241 ggttcagcgg ttcttttcca agtctcttca gcatgtccag caaggctttt gatgtgtgta 2712301 ttttacgaag caattcagca acgggccgtc cgctcatgtc tttaggcttc agctctctgc 2712361 cggtcatcca gtgctgggcc gtaatgacgt ccccattttc catccgtttt gtccaaacca 2712421 gcttcggaac aatgccttcg gcggataaaa cagctaaaaa aggtgagcta ttacgtttta 2712481 aaaaaagctg ctgcccgtta tgtttcgcat aatatgcatc tcctgtagct cctccggcgg 2712541 ggaagatctc ccaatcgcta cctagtaatt gtcccaacca gttcatatca atgttcaacc 2712601 catcatttct taaaatattt tagaattaag gctaatcgtt tctagtctat ccagcgaatg 2712661 cctttttcgt acgaatcgta taaaaataaa aaagacagct attgagagtc tcatatgcta 2712721 atcaatagcc gtcctttaaa ttttagcgct atagcacaaa cttcgtcaag caaaactctt 2712781 aagatctgat gctaaatata agataaccgt tccgatgccg tttactgcaa ccgttttctt 2712841 gatttctgtt gggtcttcct gaaatcctga tggatcacat aaaagccgat aaggtatgtc 2712901 gtttggcagc ctccactcga cggagtctgg actcgcgtga tggataacaa tgatatcttt 2712961 ccattcgtca acctcgtcaa gatcataaag cctgtatgcg ataaggtgtt cttttagcgt 2713021 caagcattca agatggcgct ggatgtctgc agcggaccta agacggaatg caggatgcgc 2713081 ttttctcagc gagatcagcc tgcggatata gtgaacatct tctttgaatg tttcacggcg 2713141 atcccagtcg agctggttga tgctgtcact ggattgatag ctgttttcca ctccctgctt 2713201 cgtccggaaa aattcctggc cgctgtgaat aaacggcacc ccttgggcaa gcaaaataat 2713261 cgcggctgca agcctttgcc tgcttcgctt tcggctgtca ttttcttgag gaagcgcaaa 2713321 gctcatttta tcccaaaagg tgtgattgtc gtgtgattcg acataattga tggactggct 2713381 tggttccgga acaatcggtg ctaatgcctt ccatccggaa gacccggcaa ttccatgcat 2713441 cacagcttgt gctgattcac cgttgccgag cgcaaaccct gttgccttaa ggtgaaaggt 2713501 gttccctttt acagcgtcac gaaacatatc attaaaaaag ccgatgcccg gcattcttgg 2713561 cgcgttcgcc aaagcagctt tctgttcatg cggcagcggt gtagccaggt cccacccttc 2713621 tccaaaaagc aggattccgg gctttgcctt agttgctttc tctttcatat aaagcacggt 2713681 gtcaatatct aaaatcccga ggagatcaaa gcggaagccg tcaacattgt attcttcaag 2713741 ccaatagacc acgcaatccg caatgaattt tcttgccatc cttctttctg atgcaatatc 2713801 attgccaacg ccggtgccgt ttgatggcat cccacattcg tcgtgccgga aaaaataacc 2713861 gggcactgtc ttttcaaagg gggaattctc cctcttatac acatggttaa aaacaacatc 2713921 cagaatgact cgcagaccgt gctgatgcag ggtattgatc atttgtttca gctctgtttt 2713981 tctcgtttga ggatcatgag gatttgaggc atagcttccc tccggggcaa agaaatgaag 2714041 cgggttatat ccccaattgt atgcatcaag cggcttctct tcatcaactc cggcaaaatc 2714101 attcaccggc agaagctcca catgtgtcac accaagctct tttacatacg ctaatcccga 2714161 agaactgcca tttgcggttt gtgtatcagt ttccgtcagc gctaagtatt ttcccttgtt 2714221 tatcatgccg ctgttttcat ggatggagaa gtcgcgaaga tgcgtctcat agatgacggc 2714281 atccacaggg tgtgagaatg gtttaagagg agcagtccat ttcatttgat ccgggcgcaa 2714341 gacgacgccc ttctctccat ttacagtcac agccttggca tactggtcaa ctgtttccat 2714401 ccattctgaa ttgttgcaga tgcaaaacaa atactcatat ccgtgaaggt cacctgtgac 2714461 cgtgacggca tagacgcctt tttccaagcg agtcatttgg aatgtgcgcc cgcttttatt 2714521 ggggtgtgaa agcttgacag cagctgaggt tgcagcaggc gcccatactt taaatacggt 2714581 atgatccgcg gtataaacgg cgcccagctc tccgtcataa taaaattcgt catcaaacgc 2714641 tgccgtccgg atgaccgcgc caatttggag atccgttttg tggccgctgg atgctctgac 2714701 gcaatggatt tttccaaatg tcacaggatg gtcggatacg cagacgtact tgtattttgc 2714761 ttcaagggag tattcctccc tgacagccag aggaaaatct gttatttctg tctcaagccg 2714821 aaacggcggt gtcatgattt ccttttgttc agcaggaatc agaacagtaa tgatattcat 2714881 gtcatcgaca tacgcttcga agctgcggcg gatgctgacc atcggaagct ctctcctcca 2714941 aacacgttta tgttttgatt cttaggggtg aaggactaga tgccagacga aacggggtag 2715001 tgcccatgat ttctccgtca gcatggaacg ggattttgtc cttcgtgtaa aatgtaatgt 2715061 ccttcgcttt aaacatcgta acgccatcca tctttgtatg ttttccaaat gccatgagac 2715121 ataaaagcca atattttttc aaaaacggct ggttttcaac gattacgata tcaaatgtct 2715181 tctcgcgcgg atttgctagg ggcgccgcct tcatgcctcc cccgtaaaac ggatggttgg 2715241 atacaacggc aaaccagaca tcatgaaatt cgcgcgtctc gtcttccgtc gtacaagcta 2715301 atgtaaacgg cttaaaggtt gccgaagcgt gcaaatgaga aagcggatac acaagaaatc 2715361 gaaggcggag aaaaagaaaa acccgtctca acggaaattc catcgccttt ttattgacat 2715421 atgcgtcaaa cccgatcccg atatgattca taaaataaag aatctgtgat ttatcctgaa 2715481 ggaaattgac gctccctaaa tgaaaggttc ttgttaacgg gcgctttacc ttcttgattt 2715541 cctgtatcag atcgattttt ttaatagaga accctcgcga aaaatcatta tacgcgcccg 2715601 ccggcacaaa gctcagctca atatcgtcaa catctttcag cccgttgaca acttcatgca 2715661 tggttccgtc tccgccaatg acgatcaggc gcttcagctt atattcctgt atcgttgaaa 2715721 tctgtctggc gagcacctcg gcgtgtcccg gatgttcagt taaaaatgaa cggtgctcaa 2715781 cctttcgttt gatcaattct ttttgaatgg acttccaaac acgcaggccg tttcgatgtc 2715841 ctgctgtcgg attaataata aaaaaccaat ggctcatctt tctcacctgc ttatgttatg 2715901 agaaaaccgc tcaaatcgtt ctcttttact ccagccactc ctgtctgcga taggagtcag 2715961 acatgcagta agacaataga gcctttgcag cctttacctg atgatgtttg atcggagcag 2716021 tgtttttctt ctgccgctca atccattctt ccgcgctccg cttatccgct atttctaagc 2716081 cgtatggcgg ctccgggtaa tcgatgtacg acgttctgct cagaagcaat tttcgaaccg 2716141 gaatctcagc ctgtttttcc tttacgatct ttgacacaac cgagtccgta cgaaacaggc 2716201 taagccctgg atttaacact gatgcagtct gagaggctgt tttcttgtcc caaaaacgat 2716261 ttttagaccc tatgtagaca ctgtcttcct cagcctctaa aaaagaaacg caataaattt 2716321 ccagaggaga aataatcaca atgcttaatt caaccgccgc ctgctgaatt ttcagcacag 2716381 gcttatacat aataaaataa gaatcaggca gctgctgggt cagataacgc aaaatgcggt 2716441 cctgcttcac ttggtttgag agttgagata tttctgaaag agtagagctt gcccatttga 2716501 gctgaaaatc atataaatgc cttttataaa aagaagcaag cgccaccctg ctcttcggga 2716561 gccttacatg aatatcttct tcgtcctcaa accattggtg tctctcttct tgtatatcgg 2716621 cttttatctc ttcttttctt cttttcaatg aaaatttttt tcgtttctgc accggttccg 2716681 gttcttcagc actggcttgc ctttcttcat gctggcgctc cgctgcttct actagtgaaa 2716741 gccagcgctc ttttttcaaa cgtacaaact ggttgatata atggtacgga tcaagctcat 2716801 atctcgatat ataatcatga attttgatga tttgtgccat gtttgtttct ccactccgca 2716861 atgaattaag ataattgaaa tttgaatatt tcctcgtatt ttggtgattg gttcaagtgt 2716921 atttgaaaga gcgaaaatcg ttcagccatc atcgaaacct cgccgctttc aaacggaaca 2716981 tgagctggaa atccatcttc gcctgtccat tttcttgcca gcgtcatatg aggatgatac 2717041 ggtctttttt ccacttgaaa gccggcctga agtacagcct gcttcgtatg ttcccgcagt 2717101 ctatcaagcg ttttgttttt ctttggctcc agatgtaaaa cgcgcggctt tctgcggtcg 2717161 ccgaatacat ctatcttgcc aaacttaatt gaaaatggat caatttctga agcaatctct 2717221 gctagcgaac cttcaagctt ctttatttgt gtctcatccg ccgctccgag aaaaattaac 2717281 gtgatatgat agtcaagcgg gtgcacccat ttttgaaacg tcaatatcgg ttcgtttttc 2717341 gcagcctggt agatcggatt tgcaattccc tcaggtatgg gaacgccgat gaaataatga 2717401 ggccgtatat ctggcatccg tctgacactc ccttctttga cagctattat tttatcaata 2717461 aagaggctgt gcggatagag gaacagtgta tgaaaacact ctcgcacaaa cgtttattat 2717521 gttaggatat tatatgacac ttgttttatt cagaaaggaa tgacaatgtt gaaaatcgtt 2717581 gcaaacacag ctgatctgat aggagataca ccgctagtga gattgaatcg gcttcagccg 2717641 gaaaatgcgg cacaagtcta tttaaagctt gaatttttca atccgagcgg cagtgtgaaa 2717701 gacagagccg cttatcaaat gatcatagaa gctgaacaaa acggtttact caagccggga 2717761 tcagttatta tagagccgac aagcggaaat accggcatcg ggctcgccat gaatgcggca 2717821 gcacgcggat ataaagcaat cttagttatg cctgatacga tgacgaagga acggatcaac 2717881 ctacttaaag cttacggtgc agaggttgta ttaactcccg gagaggaaag aatgccgggc 2717941 agcatcaaaa aagcgaagga gcttgccgaa caaattccga acagctatat tccaatgcag 2718001 ttcgataaca ctgctaatcc tgatgcgcac cgaaaaacaa cagcgcctga aatcgcccgg 2718061 gcaatagagg aaatcggaaa accgctcggc gcttttgtag cctcctctgg aacgggcgga 2718121 accattaccg gaacaggtga ggcgctcaaa gagctttttc cggatatcac ggttcatgtt 2718181 gttgagccag cgggttcgcc tgtattatcc ggcggaaaac ctggcgcgca taaacttgta 2718241 ggaacgagcc caggctttat accgccgatt ttaaatgaag acgtttatga tgaaattatc 2718301 aaaatctctg atgaagacgc gtatacgacg acaagacggc ttgctgctga agaaggaatt 2718361 cttgtcggtc cttcatcagg cgctgcctgc ttcgcggcaa tcgaaacagc gaaacgcctc 2718421 tctcctgaca aagttgtggt ctgcatgaca gctgatacag gagaacggta cttatcaact 2718481 gatttatggt catttattta aaaaaaggac tggcttcagc agaagccggt ccttttattt 2718541 tgcaagctcg taaatggcct gagcatataa cgctgtcgat ctcagcaggt catcaatttc 2718601 gatatattca tccttttggt gtgcgctgtc agggcgtccg gggaacagcg ggccgaacgc 2718661 gacaccggct tttaaggatc tcgcataagt ccccccgccg attgagatta aatcagcttt 2718721 tttacccagc tggccttcat aaaccttttg cagggttttg actaacggat gatctgcgga 2718781 cacgtgatgc ggcttgctgt ctttgaattc tcccagctca aattcagatg cgctttcgaa 2718841 tgtatcgcgg atcactttgc tttctgctgt cacaggatag cggatattga tcccgagctc 2718901 gcctccttgc ccttctttat agcgcagtgt tccgacattt aatgtcagct ctccgctgat 2718961 ttcatcctca cagtcgatgt ccagtttttt tcctcttgta tcacctgaga acttatctgt 2719021 cacaacttgc acaaaccgct ttcctgcatc gtcaagctca gtctgctgga gaaattcgca 2719081 caataaaatg ccggcattga tcccattgtt cggttccatc gcatggcagg aaagaccgta 2719141 catacgcaaa atgagctgtc cgttctctat tgcagcttcc cctttttggt ccgtcgtgcg 2719201 gagcatgtct ttaaatgaag acagaatctc ttcatttttc ggcccttcaa tgacagcttc 2719261 cgcagcgtcg ggcaccatgt ttaagcgaag gcctgattga aacgagacaa gcactgcctt 2719321 tggttcagct tgatttgggc ggtgcggaat aagtaaagaa gcatcgatga tccctttttc 2719381 cgcattaatg atcggaaaat cggcgtcagg cgcaaagccc attgttggca tttcttcatg 2719441 cttgaaataa tgctctacgc atctccaatc actttcttca tctgttccga taatcattct 2719501 gactcgcttg gacaggggca aattcatgtc tttcacgatt ttcagcgcgt agaatgccgc 2719561 cattgtcggg cctttgtcat caatggcgcc ccttgcataa atccgtccgt tgcggatttc 2719621 agctgaaaat ggatcactcg tccacccatc tcccggcggc acgacgtcaa catggcaaag 2719681 tacgccgata atgtcatcgc cctcccccca ttcaatatga cctgcgaagc cgtcaagatt 2719741 ttttgttgta aagccttctt tttctccaag ctccagcaat gaagtcaggc tggcatttac 2719801 cccttctcca aacggtttac cgggtccggc ggttgtttcg tccatgacac tgttgattct 2719861 caaaaattcc tgtgtatcac gaattaaatc ctcttttttt ctgatcactt caacttccca 2719921 gttcataatg atcccctttc cgcaagaaat gacttgcaaa aaccaaataa aacgaataat 2719981 attaatggtg ttttgttaaa acgttcgtaa ttggaggata ctatgtttca tctaaaagag 2720041 cagcaaacat ccataaagca agaaatcata gcagggctga cgaccttttt cacaatggtc 2720101 tatatcgtcg tggtcaatcc ggtcattctg gctaacgccg gggttccttt cgaccaggtt 2720161 ttcaccgcaa cgattattgc ctccattgtc ggaacgctgt ggatggccct ggcagcaaat 2720221 tatccgattg ctattgcgcc cggcatgggc ttgaacgctt atttagcctt tcatgtcgta 2720281 agcgcaagcg atggcggcat cacgtacgca acagctttca gcgcagtatt tacagcaggg 2720341 gttctcttca ttattctatc gttaacgcct ttaagaaaac aacttataga agcgattcca 2720401 aacaatttaa aatacgggat cacaacaggg atcgggctgt ttattgcttt tatcggtttg 2720461 cgtcaagcgg gaattgtggc agctgatgag tcaaacctgg tcactctcgg caatctgcat 2720521 tcacctggtg ttatcttaac gctggtcggc cttttgatca gcgtggtcct gatggtgctg 2720581 aatgtaagcg gcgctttatt tatcggaatg gcagctaccg ctttgatcgc ctttttcacc 2720641 ggtcagctcc atttttcaaa gggatttatg tcgcttcctc atttgccgga aggattgatg 2720701 atctcaaatc catttaccgc ttttggcgat gtcattcatc acggcctgta cgctgtcgtc 2720761 ttttcttttc tattagtcac catttttgat acgacaggca cgatgatcgg agttgccgag 2720821 caagccgggc tgatgaaaaa caacaagctg ccgaacgtgc gaaaagcgct gcttgctgat 2720881 tcaaccgcga cgacagtagg agctgttttc ggcacaagtc cgacgactgc atttatcgag 2720941 tcttccgccg gtgtcgcagc cgggggaaga acggggctta cggctttgac tgtcgcggtg 2721001 atgtttgcgg cttcaatgtt tttcagtccg cttgtcagcg ccttgtcagg tatagccgcc 2721061 atcacctcgc ctgctttgat tatcgtcggc agcctgatga tgggctcagt ttccaatatg 2721121 aactggaaag agatggacga ggcatttcct gcgtttctcg tcattctagc catgcctttg 2721181 acctcgagca tttctacagg aatcgcgctt ggctttattt cgtacccaat tgtaaaagcg 2721241 gcgcggggaa aatggagaga gattcatccg ctcgtcatcg ttttcgccat tctgtttttc 2721301 atccagctgt ttattttata aggatagacc aaaaaaccca aacgtcgccg tttgggtttt 2721361 ttatgtaaac aataaagaga cagcggccgc taaaaaacaa caggcggcaa acgcatagtg 2721421 caggatgttg atacagcttt ttctggcccg ataatattca tcactttcct tatcggtgcc 2721481 aattaaaaaa ggggcatcca tgaccttgtc aaaaataagc gtcaggatat aacggcaaac 2721541 ccctgtgtat accagcagcg caatcacctt cagccaaatt ggggaaacaa atatgagaac 2721601 agtgaaagct gacagtagca tgtacatctg ccttgcatac tcgccattcc tcagcataac 2721661 tttaaaaaac aactccttat agcctgtgca gatcgttcgt cttttaaata tcctttttga 2721721 atttcggtat aataatggtt ttcttctcat cctgtctttt acttttggca ttcccgcctc 2721781 ctgactcatc atcatcacaa gtcctgcaag ggcaagcctg ctttttttct cttcagtcac 2721841 ctcagcttca aaagccgtga acgaggctgt ctttttcaaa ctgcggataa ctgagaaaaa 2721901 caaaaataaa atgccaaaaa gcgcaagcaa gtgccgctca gtaaaaacaa tcaggatagc 2721961 agaaccagca aaaagaatag ctctgacaag ggtatcgcca atccatctcg aaatggagcg 2722021 cggctttctg atcctgtctt gctttaagga taaaaagaat atatgaaggc caaacaaata 2722081 acacaataga gcagtgcttt ctgcgaatgt gatgagaaca gaatgactga tcaagggaag 2722141 gacaatgaaa aagagaagca gccatttagc cagcgtggcc agaaaagaat acaaaagcgc 2722201 ataccgtttg agctgataga tgatttcctt cttttgcagc aaaaacactt tgtccgcttc 2722261 cattaaaaat gtacgaatcg aacctgtaaa catgatcagc acacacacag catacagcca 2722321 tctccattcc gccacttcag accactcata aagaaggcct cttccgttca tcaaatcaat 2722381 atactgatag atgacaaaag caatcgccgg caaaacgata tagagagcga ctgtccagtc 2722441 aatgaccgca tgcaacactt taaactgata cttataatag tcaaacagcc ttcgaaaaaa 2722501 gagcgtacgc ccgttcatag ccgatcacct tgaactgcct tataaaaaca gtcaagcaat 2722561 gactgcccct ctaatccggt cttgtcctga acatctttta acgtgccttg gagaaataat 2722621 gaacctttct caatcatata aaaccggtca cagatttttt ccgcggtatc gagtacatgc 2722681 gtgcacataa gaattccggc tccacgttct ttttcagcct taagcatgtc cacaaagcgt 2722741 ttcgtcgata tcggatcaag gccgataaac ggttcatcaa tcacatacat atccggctta 2722801 gagagaaagg cctggataag cattagtttt tgctgcatgc ccttcgaaaa ggtgacaggc 2722861 agctcatgtt tgacatgatc tagcgaaaac gtctgcagca ggctttgggc ccgatgcgca 2722921 aattcactct cttcaatgcc gtgaagtgtg ctgatcagat ccaaatgctc ccacagcgtc 2722981 agttcttcgt agaaggacgg atgctccgga atatatgcaa atgaacagtc gttccaggca 2723041 atatgccctt taaaatcttc tgaaaggccg agtatcgcct tgattgcggt gctttttcct 2723101 gcgccgttag ctccgatcag tccaaccagt tccccttttc tgacttccag aaaaacatcg 2723161 gtgagcactt tttttcggct tgtatacccg gcctgttcta ttgaagcttc aagcaaattt 2723221 gtcaaaactc actcacctcc aaaatttact acgaaataga ataaaaaaag tttctttaac 2723281 cataataata ttgagccgaa atacatagta atccaacaag gatggctgcc caacgcgaaa 2723341 ttggaaaaaa ttaataggag ttatccctag attcatcact gcaatatcgt gtataatgag 2723401 ggcgaattat tttaacaatt acagatgtct gcctttgttg ctatttcgta cgcagttgat 2723461 agtcgtgagt tgtggttagt caagtccatc cgatcttatg atagggagtg gttttttgaa 2723521 accttcaaca aaccgtatgc taactcgaat caaatcagtt tacatgttta ttcaagaaaa 2723581 aggtcttgtg acaacacagg aactggttga cgaattcggc attacaccta gaacgattca 2723641 aagagactta aatgtgttgg catataatga tcttgttcat agtccaagcc gtggcaagtg 2723701 ggagacaacg agaaagaaag taaagattac ctcataaatt gaaaattaca tagggccgcc 2723761 tgagagcggt ccgatagata acagggcgaa gaaactactg agccttgttt ttgtgtgctt 2723821 ataaataaaa ccccgcattc ggtatgcggg gtttttgtca tgcttgcggc tcatttagca 2723881 aatgaagctc ttcctctgtc agctcacggt attctccggg tgccagagcg ggatctaggg 2723941 aaacgcgtcc catcgaaagc cgcttcagat aaaccacttc attgccgact gcctttgcca 2724001 tttgcttgac ctgatggtat tttccttctg taattgtcag atatataacg gtattgccac 2724061 tgtcgtttgt tttgatttcc gcttttgccg gctttgtttt atagccgccc tctatgtaga 2724121 cacccgtttc caaatcggaa atgtcttccc gagaaatctg tgattttaaa tggacttcat 2724181 acgtttttgg aacatgcttt ttaggagaaa ggagccgatg tgcgagctgg ccgtcatttg 2724241 tgagcagcaa aaagccctct gtatctttat caagcctgcc ggctggaaat ggctcaaatc 2724301 tcatctcctc cggcgtcagc agatcgacca ctgtttgctg ccggctgtcc tcagtcgccg 2724361 acagcacgcc ctgcggttta ttcatcataa gataaatgaa ctctcgataa tcaaccggtt 2724421 ccccgtatac ggtcacctcc tgcgtatcag gatcaacgtg ctcctttaca tctttggcag 2724481 gtttgccgtc gatcatcacg gctccagcct tcacaacggc tttgacttct tttctggaac 2724541 catacccgct gttggcaagc agcttatcaa gtctcattcc caatctctcc tttataaaag 2724601 aaagcccgca gcatgcgagc cctcagtttc atcatatcta gttcatcagc ctgcatgtct 2724661 gcctttccta aagaaacctg gcaaacggcg gcctaaaatt ttctgcaaaa atcctaatcg 2724721 gtagccgcaa tacaggtaga cagctccgcc aacagcggcc gcgatcacca caacaatcgc 2724781 agcttgcatc tggccatcct gataggaaat aaagaagcct aatacccact gcacgatttt 2724841 cacggcaata cccataatgg ctgataagac cagcatcaaa acagttcgtt taacaagtat 2724901 cttatacgaa tagcctgcat ggcgcttaat catgataaac ccatataaaa gggaagcgat 2724961 atatccaagc gccgtcgcta aaatcgctcc gtcagcctgc atcagcttga tcagcggaac 2725021 attcagcaca agcttgatca cgacaccgat cacaaggctg acaaccgcaa atttttgctt 2725081 attgatgccc tgcagaatag ctgcgttgac tgtaaacaaa gagaacagaa ttgcgacagg 2725141 cgaataccaa agcaaaatgt ttgcccccag ttcaggatga aggctctctg acccgtaaaa 2725201 gaacgtatac gtcggtcctg acaatagaga gatcccgaca acagccggaa taattaaaaa 2725261 caggatcgtc tgcatcgttt gattaatctg ctgatttaac agcttatagt ttccgcttgt 2725321 aaacgattca gtaatcgttg gaattaatgt cagtccaaaa gcagttgcta gggaaaccgg 2725381 gatcatcacg agcttctgaa catacagggt tagaatcgca agcatgtcct ggctgatggc 2725441 ttgatgaccg gcttcaatca tcgctttgtt aaacgtattt gtatcaatat agttatacaa 2725501 agggatggct agtccgacaa aaacgtacgg agcagcatag ctgaacagct cgaaaaacat 2725561 tttcttgtag cttaggtttg ctgtcggacc cgtattcggc atcatcgcca gcaggctgcc 2725621 cttccgtttg ttccaataaa tataaagcac gaccagccct ccgaaggcac cgatcagcgc 2725681 tgcgaaggtt gcatagccca cagcgatgac aaggccgccg ttgaaaacct tcaaaatcaa 2725741 gaatgtcgca ctcaatagaa agatgatgcg gacaatctgt tcaacgactt gggaaacagc 2725801 tgtcggaccc atcatttggt gcccttgaaa gaatccgcgg acaaggctca taatcggtac 2725861 gaccaaaagc gctaagctga ccatgcggat gacataaacg acatgatcaa ttgtcaggcc 2725921 gttattatcc ttgcctccca gcgatatttc cgcaaacatc ggagccgata gatacagaat 2725981 gaaaaaggct atcattcctg tgactagcat aaccgacatg cccgccttga gcattttcct 2726041 gcttgtctca taatcccctt ttgaattata tttggaaaca aatttagaaa cagcggccgg 2726101 aaagcccatc gtagcaatat tcaaaaataa agtgtattgg ttgtatccgt attgaaataa 2726161 tgcaccgcct gtcgccccga ccataatgct gaagggaatt aaatagacca tccccagaat 2726221 ccgcgatata tatgtaccga gcgttaatac aaacgtgcct cttaacagtt tgcttgacat 2726281 gtttcttcat caccattttc tacgaagatt caacttttct attttaccac aactgggcat 2726341 ttagacggta ataaatacaa aagcaatcct gtgaacattc atgtccgcgg caaaagacgt 2726401 ttaaggagcg gctttctttc gctataatag tactgcggac gggtgtccgc acacgaaatg 2726461 aaaagaaagt tgatgataaa gatgaaacaa tatgacgtaa tcgtaatcgg cggaggccct 2726521 tcaggcttga tggctgcgat tgcagcagga gaacagggcg ctggcgtgtt gctgatagat 2726581 aaaggaaata aattaggacg gaaactcgcg atttccgggg gcggccgctg caatgtgacg 2726641 aaccgccttc ctgtggaaga aattatcaag cacatccccg gcaacgggcg ttttttatac 2726701 agcgcgtttt ctgaatttaa taatgaggac attatcaagt tttttgaaaa cctcggcatt 2726761 caattgaagg aagaggatca cggccggatg tttcctgtga ccgacaaagc ccaaagtgtc 2726821 gttgacgcgc tgttaaacag gctaaagcag ctccgcgtaa caatcagaac gaacgagaaa 2726881 attaaatctg ttttatatga agatggacag gcagcaggga ttgtgacgaa taatggcgaa 2726941 atgatccata gccaggcagt cattattgct gtcggcggta aaagcgtgcc tcataccgga 2727001 agcacgggag acggctatga atgggctgaa gccgcgggcc ataccataac agagctgttt 2727061 ccgacagagg ttcccgtcac ttctggcgaa ccgttcatta agcaaaaaac acttcagggc 2727121 ttatcactaa gagatgtagc cgtcagtgtg ttaaataaaa aaggcaaacc gattatcaca 2727181 cataaaatgg acatgctgtt tacccatttc ggcctctcag gacctgccat tctcagatgc 2727241 agccaatttg tcgtaaaaga gctgaaaaaa cagcctcaag tgccgatcag aatcgacttg 2727301 tatccggata tcaatgaaga aacgcttttc caaaagatgt ataaagaact gaaggaagca 2727361 ccgaaaaaaa ccattaaaaa cgtgctgaag ccttggatgc aggagcgcta tctcctattc 2727421 ctgctcgaaa aaaacggcat ctctccgaac gtatcgtttt ctgagctgcc gaaggatcct 2727481 ttcagacaat ttgtaaggga ctgcaagcag tttactgtcc tcgcaaatgg cacactgtcg 2727541 cttgataagg catttgtcac gggaggcggg gtatctgtaa aagaaattga cccgaaaaag 2727601 atggcttcta aaaaaatgga ggggctttat ttttgcggtg aaattctgga tatccacggc 2727661 tacacaggcg gatacaatat tacctccgcc cttgtcacag gcaggcttgc agggctaaat 2727721 gccgggcaat acgcccgttc ttaatcatta ctctttaaat ctcttgccgc caaactcaca 2727781 tttgaacatt ccccgcattc atgttagggt gagacttgtt ttgtttcacc tgattgcggg 2727841 gtaattttaa gagaggaatg agctgccatc gtacgaccat actaagcctg cgagcaagat 2727901 ataggcgtac acaaaaaatt agagggtgag aaatgttgaa acatatatct agtgtatttt 2727961 ggattgtgat tgcaatcaca gctgcagctg tattatgggg tgttatttct cctgacagcc 2728021 tgcaaaatgt gtctcaatcg gcacaagcat ttattaccga ttcatttggt tggtattatc 2728081 ttttagttgt ctctttgttt gtcgggtttt gtctcttttt gattttcagc ccgatcggaa 2728141 aaatcaaact cggaaagcct gatgaaaaac cggaattcgg gttattatca tggtttgcca 2728201 tgctgttcag cgcaggcatg ggaatcggct tagtattcta cggtgcggct gaaccgatca 2728261 gccattacgc aattagctct ccatcaggtg aaacagaaac cccccaagcc ttcagagatg 2728321 cactccgcta tacgtttttc cactggggtt tgcacgcttg ggccatttat gccattgtgg 2728381 cattatgcat tgcctatttc caattccgca aaggcgcacc cgggttaatc agcagcacac 2728441 tgtcaccgat tctcggggat aaagtaaacg gaccgatcgg aaaggccatt gactgtattg 2728501 cagttttcgc cactgttgtc ggggtgtcaa caagtcttgg tcttggcgca acccaaatta 2728561 acggcggttt gaattacctg ttcggcattc cgaatgcgtt tatcgtccaa ttggttttaa 2728621 tcattattgt gacagtgctc tttttacttt ctgcgtggag cggactcgga aaaggaatta 2728681 agtatttaag caacacaaac atggtattgg ccggattgtt aatgttgttt atgctcgttg 2728741 tcgggcctac agtgctgata atgaactcat ttacagattc tatcggacaa tacattcaaa 2728801 atatcgttca aatgagcttc agactgacac cgaacgatcc tgaaaaacgc gaatggatta 2728861 acagctggac gattttctat tgggcatggt ggatttcctg gtctccattt gtcggcattt 2728921 tcatcgcccg tgtatccaga ggccggacga tccgcgaatt tttaatcggc gtcttggtga 2728981 caccttgtat tttgacattt ctatggttct ccattttcgg cgtatcagcc atggatctcc 2729041 agcaaaaagg cgcgttcaat gtagcaaagc tgtccactga aacgatgctg ttcggaacac 2729101 ttgatcacta tccgctgaca atggtgacat cgatccttgc attgattctg atcgcagtat 2729161 tctttatcac gtcagctgat tcagctacat tcgtgctggg catgcagacg tcgtacggtt 2729221 ctttaaatcc ggcgaattct gtgaaactca gctggggtat cattcagtcc gccatggcgg 2729281 ctgtgctcct atattccgga gggcttgccg ctttgcagaa cacagcgatt ctggcagcgc 2729341 tgccgttttc tatcgttatc ctgctgatga ttgcctctct ctatcaatcg ctctcaaaag 2729401 aaagaagaga gatcaaaaaa gcggagaaac tcgataaacc aagaagtcca agagtgaaaa 2729461 aagcatatta acaaaaaaga tctttccgcg cctgcggaaa gatcttttta tttgcgatat 2729521 aaaataaggg cggaaaaaca gtaaagctgc tcgccgtctg ggtcgcacgc cgccgaaacc 2729581 gtatatttga tatctatcag ctgctcctcc gatatccctt ttaaaaatga attgatttcc 2729641 gtttgtaagt ctttttcatg ctcttcatca aataccgcta ccttcagcat tttatccgct 2729701 ctcctttctc tatcaatcta ttccgtttgg aacagcgtta tgatagagaa atgatgatta 2729761 tctcgtttcc ggataaaaag ctttccgtat atgggatttc ctctgtggct cgccgccgtg 2729821 ctgctccact ttcagcagca cggcataaac aatgcgcata tggcagtagc tgataaggct 2729881 gacgctgaaa aaagggacaa tgcccggcag gtacgcaagc aagaaaaaga gagcaacagt 2729941 cagcgcaagc atagtaagcg tatattgcaa atacgccaca ctgagcaaga gcgaaaattt 2730001 cacatacaga cgttttttcc agtcaaaatg gacaagcagc ggaaacacat aaaaaagcat 2730061 ggatacgaac aaaaagccaa atatcataat ggcgaagcgc aggatgtgca gaaggaaatg 2730121 acttggataa attaaggcca aatcaatata aatgatcact ccgatgagcg ccagtacagc 2730181 gccgagcaga tttgaacgaa aaaattcacc cttgtattcc tgccaaaacg ttttgagcac 2730241 cggaacgttg tcctgcccct ggatccactt ccgcatgaca gcgaataaag ccgcggtcgc 2730301 gggcatgatg ccaaacacgc cgagaccgag caacgtaaaa aacagccaca gcaagtttgt 2730361 atacgcaaat ctcataatcc attcgcaaaa acgcagcatc cgtcccagtg agccatcatg 2730421 ttccatggcg ccccctcctt ttttgcatta tacattctgc atctgaaaaa gctctttcat 2730481 gccgatcggc ttcttttcgg caaccgagcg ccacattccc tcaccaaccg cgatggagta 2730541 ggctccagct tcagccccgg ctaaaatatc atagcggcgc agcgggtctt tccctaaaaa 2730601 aagatcctca agcaaaagcg gatcacctcc gccatgcccc ccttcatttt tgaccacttg 2730661 tatcgtctgc tttgattcaa aaagcggata gtattcgatt gtctgctcag gaaaagcaaa 2730721 cggaattctg gaaggttcgt gaaattcatt tgattcaata cgtccttttg tgccgttgat 2730781 cgtcagccgg tagccttcat acggggccga aaaaataatc gagtagctta acagtgcgcc 2730841 gccatcatat ttgactgccg ccacgtacgt atcctcgatg tcaatttcct cgtcaaaaat 2730901 acacgcgtca ggcctgtatg cagtatataa gctggactgg tctcctgctt caagatgatc 2730961 atcctttata gaagctttag aggaacgggg atgccacctt gaatagtagt ggcatttttc 2731021 tttaacacgg cacgtcccgc aaaaacgccc gtcttcttcc ggcaaggggt tccactcact 2731081 gtccggccca tagtaattca aggcgccata agcaaatacc tcttccggat tttgcccgag 2731141 ccaccaattg acgagatcga agtgatgtgt tgatttatgg acagaaagac cgccggaaaa 2731201 ctgtctcgac ctgttccagc gtttaaaata gctggcgcca tgatacgtat caatatacca 2731261 atttaaatca acagaagtga ccctgcctat ttttccgtcc agaatcattt cttttatttt 2731321 ccgatgaaac gggctgtagc gatagttaaa cgcgacggtg acttttcctt cgcttttggc 2731381 ctccgcttca agcacccgat tcgcatcctg cactgttgtc accattggtt tttcagtaat 2731441 cacatctgta ttccactgaa ggctttttac aatatatgcg acatgcgtat cgtccctgcc 2731501 tgccacaatg acgatatcag gctttgagac gcgcatcatc tcgtcaaaag catcttcgct 2731561 aaactcaggc acgtgggcca gctcgggaaa tttcttcttg caaacggcaa aacgtttcgg 2731621 atcggcatcc agcaatcccg taatctcata atgagttgaa aaccgctcca tcagtggttt 2731681 gataaacata ctgaatgctc tgctgctcaa tccgcaaaag acgatgttct tcaatatcct 2731741 cacctctatc gggcttcagt tagttgagaa atcagctgca gcgcttcctc tgttttttca 2731801 gcatacacag ggataaacgc cgccatatcg cgattcaatt gaaaagaata gccgttcagc 2731861 tgttttttcc ctttttcgat ctgaacggca tagatcgttt tttctcctgt ttttttatta 2731921 acagttgtat aaggagatgt tttttcagga ggcaatccgt ttaacggctg aaaattttcc 2731981 ggatcatcgt aagcttgaaa catgtcttca ggcacgatga aaacatctcc ctcatgggcg 2732041 gtaatttcag tcagcagttt ttcctgaaaa gctggaaaga tatcgacctt cccggcattc 2732101 tgctcggcgg ccttttttat tttttcctgt acgccagcct gcatatcaga aaagagaatg 2732161 acatgcattc cgtccggcct gcttgagcat gatgccaaaa agagcactga gacgatcaca 2732221 cacaaagccg tacgtatcct ttttgtcatt tccccgctga cctaaaaaga ggctccagct 2732281 ctgtcatagc taaaataaac gcgccggctc cgtgcagatc gtttgtgctt ctttcgcggc 2732341 tgacataata gtcatagaaa ccggctgacg ttccgacaca tatgtctttg acgagaaacg 2732401 ctccgtcttc tgatgtttcg gttttatgct gaatcaagcc ttgatacgct tttagcagtg 2732461 ttgtttcgta agctctgtct agatagcctt tattgattcc ttttgcgatt gcgtacatgt 2732521 acagacagga tcctgagctt tccagccagt tatcagacct gtctccctta tcaacgatct 2732581 ggtaccataa ccccgtctct ttgtcttgat agcgacagat gcttttaatc atgtcctgca 2732641 gcgtgttttt ccacacatga cggttcggat gcttcttcgg cagctcttca atcatgtcag 2732701 caagagacat gacgtaccag ccgatggaac gtgcccaaaa ttccggtgaa cagcctgtct 2732761 cttcattggc ccaaggcatt tttttcgctt catcccaggc gtgataaaaa agtccggttt 2732821 ttgcatcctt cgtatgcttt ctcatcaatg actcctgaag cacaacctga tcaaacagct 2732881 ccgtctcctg cttcagattg gcatatttca gtgcaaacgg cccccccatg tataagccgt 2732941 caagccacat ttggtaagga taaccgtctt tgtgccaaaa accgccctca gacgtccggt 2733001 tcagtgttcc atataagctg cgcagccttt ttgccgcttt gacataccgt tcatccttcg 2733061 tctgctcgta taatggaaaa agaatgagac ctgcttgaat ggcgtccagt tcatctcttc 2733121 taaataatag attgccatta tcatcgatta agagatctgc ataagccttc gcatactcaa 2733181 aataccgctt ttccccggtt gcttcccaca gccgcaatac accgcataag aaaacaccct 2733241 gatggtagtg ccagcggttt gcaggtggca gctcctcgac tgtgtacgtg ttcataatgg 2733301 tgtttgccaa tgcctccgcg tacgtaagag gcgattttac agcgattgat tgatccattg 2733361 atcccatccc tttcctaata aattccttcc tcgccaaatt tcttcgccaa acgattcgct 2733421 agcatgacca aaatcagccc gaccgccgct ttaaatacgc cgactgctgt actgtagctg 2733481 aattggccct gtttcagccc tgcagtataa acatacgtat caaaaatttc cgccacttcc 2733541 ctgttagtcg catttaacag caaatacaca tgctcgaagc caagctccag cgtgtctccg 2733601 attttcaaaa tcagcaaaac gacgataacg cttttaatgg cgggcagcgt aatatgccac 2733661 atttgccgca gccgtcccgc tccgtccatt ttcgccgctt catacagctg ggggtcaacc 2733721 gctgtaatgg ccgccagata aatgatcgtc gaccagcccg cttccctcca gataacctgc 2733781 agaatataca ggggccggaa ccattcttcg ttcagcagaa aattgatttt ttcaccgcca 2733841 aaaaacacaa tcagttcatt aatcaagcct ccgtctaccg ttaaaagcac aaacgaaagc 2733901 gatacaacaa tgacccaaga cataaaatgc gggatataaa tcagcgtctg aacaaatttt 2733961 ttaaagagag caatccgcac ttcgttcaat agaagcgcca gcagtatcgg caccgggaaa 2734021 aatatggcca ggttcaaagc aaataacacg agcgtgtttt ttaacaagag aaaaaatgta 2734081 ggctcagtaa acagcctgat aaaatgcttc agccccaccc actcactgcc caaaatgccg 2734141 aggaacggct gataatcctg aaacgcaatc acaattcccc acatcgggac atacttaaaa 2734201 agcaaaaaat aaatacaccc cggcaaaatc atcaagtaca aatatttttg ttgaatcagc 2734261 ttgattagta agcgctttct tttttctttt ttaaaaatga ctgcatcaac agccggcgct 2734321 tgcgcttctg ctgttttcat tttttcctag cctcctttca cggattcttg cattcactgt 2734381 agcgcagcag gcaaaagtcc gtctacaatc atatgatcac atcctgtttt atccctttat 2734441 aatcaagggt tcagccggtc cacctgaaaa aaagacaccg atattagaaa atgattattg 2734501 acaatatcta tcaatctttg gattaattgt attaaggtga agtggatgtt atgaaatggg 2734561 gggttttatg aaaagaagcc aatacaagtt ttactacaaa ctgatcacgt ttttctgcct 2734621 gctcagcacc attccggtta ttttggtcgg attattttcg tacgagcact ctcagaaaac 2734681 ggctatttcc aacgtttcgg aggaaaaatt cgacacactc cagcagaccc agcaaagcat 2734741 cgagcatata ttgaaaaccg tcgatcactc tttaacccac tatgtgagtt cgccgcctct 2734801 ccttcgcaca ttgtccgagc ctttgcactc agaccaattt caaatctata accaagtgaa 2734861 ccaagagctc aattatctgc aaagctttga taccgatctg tccaacatga cgttagtcag 2734921 ttatacgaaa aaatggtaca tgaacaattc cggtttgtac cgtttgaata cagacactct 2734981 tcatgaagca gcctcagcgt acacgaaaca aaaagcgagc cgctcctatt ggacgcttga 2735041 ggaaaacaat catttgattt caaccaaaga aggcacagca gaaaactgcc gctacaatat 2735101 caatttaatt aagcagcttc ctttgaacag cacaaataca aagggattgg ccgccgcaag 2735161 catcccgagc tgttcgcttg tcaaaaatat gcccggctat tcaaacgcca acaacctgtt 2735221 tatcatcgat gaaaaaggcc tcatcatcct tcataacaat atgtctgacg ttggtgaatc 2735281 tcttcataac gacggctttg tccaaaaagt gctggcgcaa acggccaata gcggacagtt 2735341 tgaaacagtg attgaccgga ttcattataa agtcacctat caaaaatctg actataatgc 2735401 atggacttat ttttctctcg tttccctgcc tgagttaaaa aaagaagcca aatcaatcgg 2735461 ctggatcact tttgcagtat gcctcatttt gttaacgctt tcattgctgt tctcttggct 2735521 tggctcccgc catttttaca agccgatcag ggtgctttac gaatcattcg caagacatgg 2735581 agccatacaa gagaaacaac agcctcctca aaatgaattt gagttaattg aacagagctt 2735641 taagcagctg aaggacagaa atgacgacct tgaagaaacg atgaagcagc aggccactca 2735701 tctgcagcaa tattttatgg tcaggcttat gcttggaaaa ctgacggatg aggaggttga 2735761 taaccgtttt gaaagcctcg gcttaaagca aaattggcgg caccttgccc tgcttgtgct 2735821 ccaaattgac acactgaatc atacgcctta tgagaaaaaa gatatggatc tgcttttgtt 2735881 tgccgtcaac agcctgattg agcgcaacat cccgacggac aaacatcttg cccccgccgt 2735941 agttgacaaa cagcaggcga cgattttgat caatcaaagc gggacaaagg aagaattcat 2736001 ggctgagctg aatgagactg caaggatgat tcaggaaaaa gcggaagctg agctgcagct 2736061 gtctgtcagc atcggcatca gccagccgtt tgatgtgctg acaaaagcga aaacagccta 2736121 tgcggaaggc tcagaagcgt tgaaatatcg gctgaaagcg gaaaacaagt cgatcatctt 2736181 ttacgaagac cttgaccaga aaaaaacctt caaaacccat tttccaaagc agcttcagca 2736241 tgagctgttc gatgctgtca aagcaggaga caaggagaaa gcggataaat gcctgcacgc 2736301 gattttacaa gccattttca cccagaacac caacccgtat caatttcaaa tcgccatcgc 2736361 ccgttttttg aaccatgtga ttgagctgat gcatgtgctt gggatcgaat tgtttgagct 2736421 tgaagaaaac aaaatgctgt atgaccaaat ttttgagctg aaaacgttcg aggataccga 2736481 aaactggcta aagaatgagt ttattgatcc gatgacagac aaagtgaacg cccgcgcgga 2736541 tgcccagtac aaaaatattt ccgacaacat cattcatatc atccatcatg agtttgaatc 2736601 cgaattgaca ctggacgaaa tcgcacgcag gctgcattac aacccaaatt atttaagcag 2736661 tattttcaaa aaagaaatgg gaatttcatt cagcgagtat gtctcaagct accgacacca 2736721 tatggcgaaa agctggcttg ccgaaaccga catggcggtc aaggacattg ccgaaaagct 2736781 gaaatataaa aactcccaaa acttcatcag atcatttaag aagctggaag ggattacacc 2736841 gggaaactac cgccagcaaa aaagaagcat gtaaaaaacc caaaaccgct tgcgcgtttt 2736901 gggtttttcc aatgttattt tgcttgttta aacgcttctt cgtattcctg aataatttgt 2736961 tttcctccgc ttgactccca tttttccact tctttatcga actggctttc tgtgatgtct 2737021 ccaatcatat atttgtaggt cgcgtcatca atgattttct tcagttcgtc accccgttcc 2737081 gactccgatg cggaatacag gctttcagcc gggtttgaga cgataatctt ttcattgtcc 2737141 tcggtcagct cctcgtacgc cgtccgaagc ggatctccag tgttttttaa gtaggcttta 2737201 tcaatggcaa ttaaagcgga cagcggctga atatcagtct gccagtcttt tacctggctt 2737261 tctttgcgtg taaacgtttt gtcctcacct ttgttgtaat gaacgccgtc aatgccataa 2737321 gtcatcaggc tatagacatc ttcttcggca attcggtcaa aaaacgccaa gatccgttta 2737381 agctcagctt ccgttttcac actcgttttc gggaaagcaa acacgccgtt atggcctcct 2737441 gatgcccata cccgctcttt cccatctggg ccttttatgc ggttgatgat ctcgagcttc 2737501 atcgatttat cagaggcatg gtcgcgcaga ttgaccgcat ctaccatatt gccaatataa 2737561 attccggctt ttccttgaga aaacagctct tgctgctggg ttttgcttgt gacgggaaaa 2737621 tccttattca tatacccgtt atcacgcagc tttttcatat agttcatcgt gtctttgtat 2737681 tcctgtgtca tgaaatcagg cgtgaatttg ccgcccgatt ccttccaatc tgtcggcatg 2737741 ccttcatacg agccaatcgt tttaaacgcg ccgtaaatca agtcattacg gtctgccagc 2737801 ccgaatgtat catctttccc atccttgtcc gggtcgtcct ccgtaaatgc tttggccact 2737861 tcataaagct catccaacgt tttcggggtt ttcaaattta aattgtccag ccagtccttc 2737921 cgaatgacga tcccctgtct ggaaagcggg cgctctctgt atatcccgta gagcttgccg 2737981 tcaattgtca catttttatt aatgagtttg ttcattttgt ttaagttggg ataatccttg 2738041 atataatcgc cgatttccca aaacattcct gaccgaaagg cattcatgac tgacgaattt 2738101 ttaatatcct ggatggtcac gatttgcgga agattgccgg ctgcaagcgc tgcattcagc 2738161 ctgtcttctt tcaccgcgtc tggaacccag gtgatgtcga gttctgtatt tgtcagcttt 2738221 tcaatttctt taatcgccct gtctttcggc ggctgctggt gatacaaaat cgccatccaa 2738281 gacagcttta cctttgaatc tgggccagct ttgccttcag ccgaagactg atcagttcct 2738341 ttacagcccg ccagcactcc gccgagtgcc agtacaagca caatcaaaag caccctccat 2738401 ttgtttccca tcgtacccct ccgtttcata tttctttatc ctttgacaga tcccagcaaa 2738461 gctccttttg caaaatgctt ttgtataaac ggatagacaa gcagaacagg gatggtcgcc 2738521 accactatga ccgccatttt aatggtttgc tcaggcggcg ggctgcccga ccccatttca 2738581 gacatatccc cctgcatacc gcttgataca atgacgattt ggcgcagaag cacctgaatt 2738641 ggccattttg ctgaatcatt taagtacaag atcgctgtca tatacgtgtt ccaatacgtg 2738701 accgcataaa atagtgaaat cgttgcgatc gcaggaagag acagcggcag cacaatttta 2738761 aagaatatgc ccagatcatt gcacccgtca attttcgcgg actcttccag gcttgacggg 2738821 atattttgaa agaagttttt cagaatgatc aggttaaagg cattaatggc tgtcggcaaa 2738881 ataagcgccc agtaagaatc gagcaatcca agcgatttga ccacaaggaa agtcggaatc 2738941 atgccgccgc taaacagcat cgtaaatacg acgagaaaca tgagcggctg ccggccgatt 2739001 aaatcacggc gggataaccc gtaagccatc agtgacgaaa gaaacatgct gaccgcagtg 2739061 cctatcactg tcacaaacac agaaacaagc aaactcttat aaataatatc tgttgaaaaa 2739121 atgtagcgat aagcatctag cgaaaaagtg gtcggtatta aaataaattt tttcgacacg 2739181 acttcttcta ctgtggcaaa ggatgctgcg ataacatgaa tgaacggaag tacgcatatt 2739241 aaagcgaaca tcagcaagaa accataaatc aacatatcaa acagacggtt tttcagtgaa 2739301 tgtgcgatag ctcccacctc cctttgtaag cgttatcata tttttggaaa ccgagctcag 2739361 catgtgacga tatcgtgtct aaaatgtagc aaatctgtga ttgccatgtc tataatcatt 2739421 tgaacagtgt ccccggccgg gcgggggctg ccgcgaattg agaccgataa caaaagaaaa 2739481 agagcataat cttagaaaat gattatgctc cgttctcctc ctcgttcaga agttcagccg 2739541 tattgatttg tggcgaaaac ccaagttcat tcacggcaga ttcaatggac catggccggc 2739601 ccggattatc agagacggcg taataagtgc cataccggat gttggtctca atggcggctt 2739661 tgaaaatcga cagcagatcg gggtgagaaa gcagtgtctt tttcgtccgt tctttttcat 2739721 gcagcgtatc catttcatct gtcacgactg ttccgattcg aaggttgatt actgatagct 2739781 tattttccaa ataaaacaaa tggccgatct gttcagaggt cagctttaat acaccgtaca 2739841 agttttttga cagcggataa tcgcttgttg tgatttcccg tcctaagagc gagcgcccgt 2739901 ctttttcata tacatctgtg acatgattgc tgctggcgaa cacgagcttt tgaatgccga 2739961 gctccgctgc cgcacggcac agataatagc ttgccctata gaaaacatcc gtcatttttt 2740021 caaactcagc gatgtccata atatcgtatt tgattttcac agcgagtaaa ttcaagatgg 2740081 catcggtatc ttttggaatc ttcttcaaca gctcctcata atttgccgcg tcagcctgaa 2740141 tggaagaggc tttgccatcg aaatgatctt tatcaagcac agtcacttca tagtctgaaa 2740201 taagcccttc agcaagcagt ctcccaatca caccatttcc gccggcgatc agcacttttt 2740261 tcacgatgtt cactcccctt ttttatagat tgcccatttt cggcggggct gacacttttt 2740321 tggcactcac attcttaggc ttattcaaaa gtcaccggca gctcctcaag cgcccgaaat 2740381 ccaaaaagcg gccgataccg ccattcaaaa tccgcaagat taaggctggg cattcgctgc 2740441 agaagagtgt taatcgcaat ttgcgcttct aatcgtgcca gcgaggaccc taagcaaaca 2740501 tgatggccat gcccgaatga aagatgcgga ttaggacttc tcgtaatatc gaagacatcg 2740561 gggttcgtga atatgctagg gtctcgatta gccgctccta acaaaagata gacttgttct 2740621 ccttgacgga tcgtcacccc gcagatgtca atatcctctg acgcaactct ggctgtcatt 2740681 tgcgtggggc tttcatagcg taaacattcc tcgactgcgg taccaataag atctggattt 2740741 tctctcagtt tcaaaagctg ttctggatgc tgcagcagac aaaggactga attgctgatg 2740801 agattgaccg ttgtctcatg tccggcgatc gccagcaata tgcacgtaga tgccgcctcc 2740861 tcttccgtca gcttatcctt ttctctcccc ttcaagagca tgctgatcat atcctgttga 2740921 gggtggcgtt ttctcttttg aatcagctct ttgaaatatg ccatagcctg cacagccata 2740981 atattgccct ctgttaatgc ctttcttgag cgggtaaaat caatcgtttg aatgagactc 2741041 gcagcccact cctttaattg ctccctatct tcctccggta cacctataat gttagctatg 2741101 acaaaacttg ctaaaggaaa agcaaagtcc gaaatgacct ccatcttttt tttaccttgc 2741161 acttgatcaa gcaaatgatg gacagtttca atgatatacg gctgataact ctctgtcgtt 2741221 ctcggcgtaa acgctccgct ggcaagcgtc cgcaatcgtc tatgatcagg ctggttctga 2741281 aacagcatca tttgattttg cacatgtgaa aggtcctgat atttggttga gctctcaggc 2741341 agcggggtgc ggactttgaa tctcgcatct ttcaaaatag cagccgtttc ttcatatcct 2741401 gtgacatacc agcccgggta ttttaagaaa ctccctttat agataggatg aacagctcgc 2741461 aatgtgtcgt aaaaagaata tgggtttttc aaaaactcag aagatgcagt tgacgatgca 2741521 attgtcacgt gattttctcc tttctgttca aaaataaaaa caatcgacat cataccgatt 2741581 gcttttattg attctttcag cttttcgcac ttaaactagc cttcatttct tcgactgatt 2741641 caacttcaaa gcctaaatca ctcagcattt tatgatcctc cgtctcctct tgcccggcag 2741701 ttgttaagta gtctccgaca aaaatggagt ttgcggcgta aagccctaat ggctgcaatg 2741761 tgcggagatt gacctctctt cctccggaaa tgcgaatttc ttttgatgga ttgataaaac 2741821 ggaacagcgc cagcactttt aaacaataca gcgggtttaa ttcgttgacg ccttctaacg 2741881 gcgtgccatc aattgcatgc aaaaaattca caggaatgga atccgcgtca agagccttca 2741941 agcttttggc gatgtcaatg acatcctgtt tcgtctcctt catcccgata atggcgcctg 2742001 aacacggaga cagccccgat tcttttgcga tttcaaccgt attgactctg tcatcgtatg 2742061 tatgtgaggt tgtgatgttt gaatggtttc tctgtgacgt attcaaatta tgattatagc 2742121 ggtctactcc tgcatctttg agccgcttcg cctgctctgg cttcaacagt ccaagacatg 2742181 cacaaatctt cagtccatac gtctctttaa tttcctgaac cgcatctacg acctgatcca 2742241 cttctctgtt agacggacct ctgccgcttg ccacgataca atatgtgccg atattcagat 2742301 cgtgcgcccg cttcgcgcct tcaagcagcg tttccttatt caccatccgg taagactcaa 2742361 tcggcgcttt cgaaatcgca gactgtgaac aatagccgca gttttccggg cagagcccgg 2742421 atttcgcatt cataatcata ttgagcttta ctttttttcc gtaaaagtgt tttctgatgt 2742481 gaaaagcccc gtgcattaat agcaaaatat cttcatcagg acaatgtaat attgaaagcg 2742541 cctcttcgtc agtcacttct gctccagcca gcacccggtc tgcgagttcc atccattgat 2742601 tcattctcat acccccactt gattcatcag taatgataga ttgatatggt cttttaccat 2742661 atgtagaacc gtttctttcg tcacgttggc aagctttggc gtaaccccta aaatcggcac 2742721 accgcataag cgctcaatca tctcaggatt ggttttttca tcttcatcag gagagtcact 2742781 gattccattg atgataattc cggcgattgg aagccccatg ctttctgcat atttgacagt 2742841 taaaaaggta tgattaatgg ttccaaggcg aggacgcgcc acaataatca tgggaagctg 2742901 caacgctttt atgacatgac tgaccaaata gtcctctccc aatggcacag aaataccgcc 2742961 tgcaccttct acgatgaagc attcatgttt ttctctaatc cgcccccaat ggcttaaaac 2743021 ctcttccatg gtgacagtct ttccctcaag tttccctgca acgtatggtg caagcggcgc 2743081 cttgaaggca aaaggcgtaa tgtcttcatg agaaagactg gtctgcgaca tatctttcag 2743141 caaacttgta tcactatctg gatgatggcg cgatatcccg cttaaaaatg gtttatacac 2743201 cccgacatgt ctattattgt ctttcaataa ggcagcaaga ccgctggata taaccgtttt 2743261 ccctacttct gtatcagttc ccgtcacaaa aaaacccctc aaatgatgtg cagctccttt 2743321 ccgattgaat gaaatgtttg cagcaaatga tcaatatcac ccatactgtg gtcagacgtg 2743381 attgtaattc gaatccggct ttcacccggc gcaacggttg gcggccgaat ggcaggagca 2743441 taaattccct tgccctgcag tttttcagca aataggaccg ttttatgggc atcgccaatg 2743501 actacaggaa taatcggtgt gtgatctcct ttcaccacat aacccatatt cttcagactg 2743561 gttctgatca tgctgatata agaaaataaa agctgtcgtt tttccctgct ggcttcaatg 2743621 atgttgaaag cctcgtgagc agccgcacag ctggctggcg gaatagcggt ttgaaagata 2743681 aatgttctgg catggttcag caaaaagtcg atgaagaccg ctgatcctgc cgcaaaacct 2743741 ccttccgcgc caacagcttt gcttaaggtg ccgataacaa tgtcgggaca aacaccaaag 2743801 tattcactcg ttccttgtcc cgaatcgccc aaaactcctg ttgcgtgggc atcatcaacg 2743861 accacgaagg catgatagcg tttcgcaagt gagatgatct gatcaagagg ggcgattgtg 2743921 ccatccatgc tgaatactcc gtctgttacg ataaaacggc gctgataacg ctgtgtttca 2743981 ttcagcttgt tttcaagatc attcatatca atatgccgat aaacaactgt atcagcctta 2744041 gaaagtcggc agccgtcgat catacttgca tgattgagct ggtcacttaa aatgacatct 2744101 tccttttctg gcaaggatga aaggacaccg acattggcca agtaaccgct cgaaaacagc 2744161 agggccgctt ctgtcagttt aaagctggca atcttctttt ctagcttttc atgccagacc 2744221 gaattgcctg tcgttaaacg tgaaccgctg cttcctgtcc caaattgctg caatgctgtt 2744281 tgggctgcat cgatcaaacg tctatcgctt gcgagcccta aataattgtt tgaggaccag 2744341 accgtttgat tttcgccatc aatattcctc tctggaaccg gcgctccatc cattgaccgc 2744401 aggttacgat gtacgccggc ttctttcatt ctgtctaacc gctcgtttaa ccaggaatca 2744461 atcttcaagg ctcgtaacct cgtggatcgc ttgtttcata atggcaacca tttccgagag 2744521 ctcttcagct gtgctggcaa gaggaggaag aaatgcaatc acgtccccaa gcggtcttgt 2744581 cagcattcct aactctctca tttttaagga aactttgtat ccaatccgcc gatcagccgg 2744641 gtaaggttct ttagtttcct ttgatcgtac aagctctgca ccgcacataa agccaagctg 2744701 ccgaatatcc ccaacatgag gaagagcgtg cagatcttga agaagaaaat ggagcttttt 2744761 acttttttcc gctacttgtt ccacaatgtt ttcagattca aataatgcca gattttcaag 2744821 cgcaaccgca cagccaagct gattgcctgt ataggaatgg ccatggaaaa aggtttttag 2744881 gttttcataa tcatcataga atgccttata gatgtcttca gtggcaaacg taacggcaat 2744941 tggcaaatag cctcctgtaa tgcctttacc ggcagccatc agatcaggct ggacattctc 2745001 gtgctcgcac gcaaacattt ttcctgtacg gccaaagcct gtagcgactt catcaacgat 2745061 cattaagaca tcgtatgttg tacatagctc gcgcacgcct gccaaatatc cttccggcat 2745121 cacgatcata ccggacgcgc cttgtaccat tgattcaatg gaaagcgcgg caatttcctc 2745181 atgatgttcc tcaagcagct gtgcaagctc tcggaggcac tgatcacggc actcatcagg 2745241 atcaccgctt tcagaacgat acacataagg aatcggggcc ttgtaactct cgaacatcaa 2745301 cgggccgtat acgtggtgaa aaagctcaat tgaaccgaca ctgacggcgc caatcgtatc 2745361 accgtgatac ccgtttttca ttgcgatgaa tttttgtttc tcgggcttcc cgatgttctt 2745421 ccaatactga aacgccattt ttagggctat ttccatcgcc tctgcgccgc tgtctgaata 2745481 aaagacccgc gtgagctttt ttgggctgat gtcgattaat gtttcggcaa gctgggttgc 2745541 tggaacattg gtcatgccca ataacgtgga gtgcgcaatt tttccgagct gtttttttat 2745601 ggcgtcatct agttcttttt tgcggtgtcc gtggacatta agccaaaccg atgaaaaacc 2745661 gtcatagtat tccttgccgt ttatgtcttt gactttgatt ccagtcccgc tttcgatgat 2745721 taaggggttt tcatcataat ctttcatttg ggtaaatggc agccagaggt gctttttact 2745781 tttttctatc aaatcatgag tcatgatctt cctcccactc tattaaaata ggctgcttct 2745841 ccaggtcatg tatgtacgtg tttacatcat tggatccatc aataaaaaag actcggcagc 2745901 cctcttcagt cccgtattct ttcattgctg taatacgctg atagcccatt ttcttacccg 2745961 caacatagcc tgttatgtaa tccggatcgt ccgaccagca taattctgca acgactgccg 2746021 ggtgccggct tacctttgaa gcgagcgcaa gggcctcttt tattcttgaa tgagctggca 2746081 cgtgactgtg aagcgcccat ttttcaaaat tagcgtccgg ccaatccatt ctggagaccc 2746141 gcaccccttt ttcttttgtt tgatccattc gcttgcctgt atgaatatca aacaacaccg 2746201 cacccctgac atctgaccat tcagggattt gttcatatgc tttttcaatc acgtctcgtg 2746261 aaacgccttc tttttccaat aacaatcggg caagcttttg tccttcttcc gggcagctca 2746321 cttcattcgt atgcacaggc aatggctgaa tggtttttat cgattcatgt acctcttcaa 2746381 attgaatttg cataaaatca ggttttcctc ttgaatggga taaccctttt tctaataaag 2746441 cattgactgt atgcttcatc tcatggaaag gaataagccg ttctccgccg gatatatgct 2746501 ttccgccgtc ttcatgagat ccattcattg aagccctcat tctgacacta taaaaagttt 2746561 cttcttgcat catttctcgc cctttcactg ataactgaag aacgtgtagc gcttctcacc 2746621 taaattgtta accaattata ttcaaaggtt aacaattaga atatattatt ctctcctgtt 2746681 tctgtcaata gaagaaagga tcgatttatg gcagttggtt aaaaggaaac aaaaagaccg 2746741 ttttcacaca aaacggtctt tttcgatttc tttttacagt cacagccact tttgcaaaaa 2746801 ccggacagct tcatgcctta taactgctgt ttcgaaatgt cccgaagcag aacggaccac 2746861 tcggtagcaa tcagcagctc cctgtccagc atagacagct gtcaattctt tttcgatttt 2746921 gtccacgccc tcagccggcg ttaaccgatc gtgtacacca acaagactaa ggtgcgggcg 2746981 cggcgcgatc aggctttgga tctccgatgc ggaaaaatgc tttgcaagcg atgggacgta 2747041 ataataaaag ccgtgcctgt caagattctg tgttttgatc agcacgtgat gatccacctg 2747101 gctgcacaaa tccacacaca ccttaatccg gtcatcgagc gccgctgtcc accacgccat 2747161 caaacctccc atagacatgc cgatggttcc gatcctgtca ggctgaacat cagagcgtga 2747221 ctgcatatag tctaacgcac ttaaactgtc ataaatcatc atcccccaca tcacttttcc 2747281 ggtgagaagc atttctttaa atatctcgct ttccgctttt ccccgccgat ctccaaaccc 2747341 ccaatgatca atcgcaagaa cgccgtatcc gagtgaagta agctcatcag aaaaagaagg 2747401 cgttttcaaa taatccgctc cctcaatcag ctcacttttt cccctatcat actggcctcc 2747461 atgcgaatgc tgaaacaata cggctgggca cggtccttct gttttcttcg gcttcacaaa 2747521 ataagcgggc gccttttcat gtccatttaa atcgagcagg agcgtttcaa cgatattttc 2747581 ttctctttct tcaatacgta atgtctcaac actgattggc ctccgatcag gcaaatcacc 2747641 aagcaatcga aacagttgct ttcttctttc ggctctcatc ccatcaccct tccttattcg 2747701 cttacttcac atttacgaga cagatctggg ttccccttta tttttccaac ataaatcaca 2747761 tcatttacta aatatttagt aaatattatg gaatatttcg aaaacaatta ttgtaaccgc 2747821 ttacttttat atgataatat caatttatca aaaacagatg agttaatatt ttactaaata 2747881 gatgagaggg atacccatgg ttcgtattaa agatatcgcc ttgaaagcta aagtttccag 2747941 cgcaactgtg tccagaattt taaatgaaga tgagtcgctt tctgttgcgg gcgaaacgag 2748001 acaaagagtc atcaacatcg ctgaagagct tggttatcaa accgttgcca aacgccgaaa 2748061 atcccgcggg caaaaacagc gggctcagcc gctgatcggt gtgctgagct gtctgtcccc 2748121 tgatcaggaa aggcaggacc cttatttttc ttccattcgg aaagggattg aaaaggaatg 2748181 ctttgaacag gaaattttca ttacaaattc gattcatctc ggctcctttc aggaacatat 2748241 ctttcgggaa ttggatggtg tcattgtcat cggccgtgtt catgatgaag cggttaagca 2748301 tatcagcggg aggctggagc atgccgtatt tatcaatcat tcaccagatc cgcaagcata 2748361 cgattcgatt ggcatcgatt ttgaatcggc ttcacgccag gcgattgatc accttttcga 2748421 cttaggctac aaacggttag gctacattgg cggacaagaa aaagagcata cgctgaagga 2748481 cggccaaagc attcgcagaa cgattgaaga taaacgcctg accgcttttt tggagtcagc 2748541 cgccccccag cctgagcatg tgctgatcgg agaatacagc atgcgtgagg gctatcgcct 2748601 gatgaagaaa gcaatcgatc aaggccatct gccggaagca ttctttattg ccagcgattc 2748661 tatggcgatc ggcgcattaa aagcgctgca ggaagccgga ctgcaagtgc cgcgggatac 2748721 cgcaatcgtc agctttaacg gcattgagga agctgaattt gccagcacgc ctttaacgac 2748781 ggtgaaggta tacacagagg aaatgggccg gacaggcgta aaactgctgc ttgaccgtct 2748841 caatggccga acgcttcctc aacatgtcac cctgcctaca acattaatcg taagacaaag 2748901 ctgcggatgt acagcaaagg aggtgacata agcaaagatt catcacgatg ataaggagga 2748961 aaagatgaaa cacacttttg ttttatttct ctctcttatt ctgcttgttc tgcccgggtg 2749021 ttcagcagag aaaagctcag cagataccgc aaaaaagacg ttaaccattt attctacaat 2749081 gtcaaccgac agtgaaagag atacgttcag aaaactagcg gcagcattcg aaaaggaaca 2749141 cagtgacatt catgtcagcc ttcatttccc aggcaatgac tatgaaaata tgatgcgtgt 2749201 cagaatggcg gccaatgatt tgccagatct attcgataca catggctggg ggaaaatcag 2749261 gtacggagaa tatacagcgg atctccggga tatgaaatgg actcaagatc ttgatcccaa 2749321 tttaaacagc atcctcaaaa ataaaagcgg aaaggtgtat gcctatccaa tcaatcaggc 2749381 aaaagacggt ctggcgtata atcgcaatat tttagaccgt tacggcattg ctccgccgga 2749441 aaccatggat gactttatca aagcactgag aacgattaaa gaaaagagca agggaagcat 2749501 tgttcccttc tggtttgccg gatatgacaa aagctcattc gcccaatatt acgaccaatt 2749561 cgctacacct cttctcatca cagaccctgc ccataatgaa aaaaaacagc tcatcaacgg 2749621 cacttttcaa tggagtaaat tcacttattt atcagaaatc ctcaaacaaa tgcagaaaga 2749681 aaaattgatc aatatcgacg ccgtcacggc aaaaaaatca cagctcattg aattaatggc 2749741 ccaaaacaaa atcgccttta caatgcaagg cggcacactc ggccaagacg ttgcccagat 2749801 caacccgaac gtcaaggtcg gcattatccc gacacctgcc atccatcccg gtgatgaccc 2749861 gatatggatc ggcggtgaac gctacaccct tgcagcatgg aaagattcgc ctcaattaaa 2749921 agaggcaaaa gattttatcg catttatggc ccgcccggcc aatgccaaac aaatggctga 2749981 agccacatcg cttccttcag ggctgaccaa tgtgaaagct gatattttct acgcaaacga 2750041 ttatgagtat tatcaagatg tcaaagtcga gccttacttc gaccggttat acttgccaaa 2750101 cggaatgtgg gatgtcctgg gcacggttgg gcaggagctc gcggctgaca ttttggcgcc 2750161 tcaagacatt tcgcagaagc tgggaagaga atataaacga ctccgggagc aatccgaaac 2750221 acagggagct gaaaacaatg agtgagatcg caagggacgt tcatgtgaaa caggttaagc 2750281 caaaaaagca gtcctcactt tggtggatgt acattcctgc tttgctctcc gttctggtct 2750341 ttatgattta cccgtttgtg aaaggcacat tgattacctt tacaaactgg aacggatttt 2750401 cacaagtcta ccaatgggtt ggattcgcgc aatatgaaag gctgttttct gatcctgata 2750461 cttggcatat cttaaaaaac acgctgcatt acgggcttgg cagcaccttt tttcaaaatg 2750521 tggtcgggct tctgtacgct ctcctcttaa atcaaagcat taaaacgaaa gcggtaacaa 2750581 gaacaattgt gtatttgccg gtgatgatca gcccgctcat tatgggctac atttggtact 2750641 ttttcttctc ctatgacgga ggcgcgctca acgatttgct cggggtcttc ggcatcagcc 2750701 ctattaatgc gctcgccagt ccctcgctca atccatggat cattgtcatg attaacacct 2750761 atcaatatgt cgggatcgct atggttgtct acttagccgg tctgcaaagc attccgaaag 2750821 actactatga agcggcgcaa atggatggcg cgaaacaagg ccagcagttt tttaccatca 2750881 cgctgccgct gttaatgccc tccattacca ttaatatagt catcaacatt atcggaggct 2750941 taaagctgtt tgacgtcatc attgcactca ccgcaggcgg ccccggaaat gcgtcacaat 2751001 ccatgtccac gtttatgtat gatttgtatt tcaaacggca ggatgccggc tatgccgcaa 2751061 cgcaaggcat atttatggca tttgtcattt tgatcatcag cttttgcgcg cttgcgtact 2751121 ttaaaagaaa ggagacggaa atgtcatgag agccgcccgt acaaaaagca tgcggatcat 2751181 tacgcttctt gcagccattg tggcctgtgc gcattttatt cctttttata tcctgctgac 2751241 cacttcattg aaagcaaaag gagactacag ttcgaaatgg atatttccag ccgacatctc 2751301 ctttcataat ttttcagagg cgtgggagcg cgcttcgcta ggaaactctt ttataaacac 2751361 catgatcatc acaggttttt ctgccttgtt attaattata ttcggctcac ttgccgccta 2751421 cccgcttgcc cggcgggaaa cgaaactgaa taaagccgtt tttgccttgc tgatttccat 2751481 tatgatcatc cctccgttaa cgtccatggt tcctttgtac cgaatggtcg tggacgccgg 2751541 aatggtcaat acacacgcaa tcgccatttt catcaataca gcggcttaca tgccgttaac 2751601 cgtattctta tattcaggct ttatccgatc gaccattcca aaagagcttg tagaagccgc 2751661 aagaattgac ggtgcaggca tgctgaaaat cttttttacg attgtgtttc ctctgctgaa 2751721 gccgatcact gcgaccatct gtatcatttc ttgtgtcttt atttggaacg actatcaatt 2751781 tgccattttc tttttacaag atcaaaaggt tcagacatta acagtagcca tggcaggttt 2751841 tttcggagaa aacgcaaaca accttcattt agttgccgca gcggcactta tggcaatgct 2751901 gccgatggtt gttctgtttt tggcgctgca aaaatacttt attgccggcc tgtcttccgg 2751961 agcggtaaag ggttaacatt aaagggggaa gcaatatgaa aaagattaca tttatcggtg 2752021 cagggagcac gattttcgcc aaaaatgttt tgggagactg cctgttaaca gaggcactga 2752081 atggatttga gttcgctctt tacgacattg atcccaaacg cctgcaggaa tcccagctca 2752141 tgctcgaaaa tctaagagac cgttataacc caagtgtggc catcaacagc tatgatgaca 2752201 gaaaactcgc cttgcaaaac gcaggctatg tcatcaatgc gattcaggtt ggaggataca 2752261 aaccgagcac agtcatcgat ttcgagattc ctaaacggta tgggctgcgc cagacgatcg 2752321 ccgatacagt aggcatcggc gggatattca gatctctcag aacaatcccg gtcttatttg 2752381 atatcgcaaa agatatggag gaaatgtgcc ctgacgcatg gttcttaaac tatacaaatc 2752441 caatggccac tcttacaggc gccatgctcc gctataccaa tatcaaaaca atcgggctct 2752501 gccacagtgt tcaagtgtgc acgaaggatt tatttaaagc tctcggaatg gagcatgacg 2752561 gaattgagga acgcattgcg ggcattaatc atatggcttg gcttttggaa gtcaaaaaag 2752621 acggcacaga tttatatcca gaaatcaaaa ggagagcgaa agaaaaacaa aaaacaaagc 2752681 atcatgatat ggtgcggttt gaattaatgg ataagttcgg ctattatgtc acggaatcgt 2752741 ccgaacataa cgcagagtat cacccgtact ttattaaacg gaattaccct gaactgatca 2752801 gcgagctgca aatcccgctc gacgaatatc cgagaaggtg cgtcaagcag attgaaaatt 2752861 gggagaaaat gcgggatgat atcgtcaata ataaaaacct tacgcacgaa cgctcaaagg 2752921 aatatggttc aagaattata gaagcaatgg aaacaaacga accattcacc ttcggaggaa 2752981 acgtcttgaa tacagggctg atcaccaacc ttccttcaaa agcggttgtg gaagtgacat 2753041 gcgtcgccga cagaaaaaaa attacaccgt gcttcgccgg agaactgcct gagcagcttg 2753101 cagccttaaa ccggacgaat attaatacac agctgatgac aatcgaagcg gctgtcacac 2753161 gaaaaaaaga agcggtttac caagctgcaa tgcttgatcc gcatacaagc gcggagcttt 2753221 ccatgaagga catcatctcc atgtgcgacg atttatttgc agcacacggc gattggcttc 2753281 cggaatacaa ataaaaacta ggggaccgct ctcccctagt tttttggttt tgtttcgcct 2753341 tcccaggcca tcatgccgcc ttcaacattg actgttttaa agccttgctc atccaggtac 2753401 ttgcagacgt tcatgctgcg cattcctgag cggcagataa atacgtactc tttgtcttta 2753461 tcaagggttt ccattttttc aggaatatcc cccatgcgaa tatgaacggc ttgcgggatc 2753521 atgccttccg ctacctcttc atcttctctg acatcaatta aatataattc ttcgtccgcc 2753581 tcaatttttt ctttcaaagc ggctgtgctg atttctttta tttccaaaga aaacactcct 2753641 attcacagtg atcatgttca gtatatcaaa gtcagccgaa cgattgctat tctgagactg 2753701 atgaaaaaaa atcccctttt ggcaaagggg attttttcta ggcttagttt gccacaatat 2753761 tgacaagctt cccaggcacc gcgatgattt tccgaatcgt tttgccttca agctgctctt 2753821 tgaccttttc atctgcttga gcaagctgtt ccagctgttc tttcgttgca tcggcaggaa 2753881 cctgtaattt cgcttttact tttccgttca gctgaacaac gatttcaact tcatcatcca 2753941 caagttttgt ttcatcatat acaggccaag cttcgtaggc aattgtgccg gaatggccaa 2754001 gcttctccca tagctcttcc gctaagtgtg gcgcgacagg agaaagaagc ttcacgaagc 2754061 cttccatata ttctttcggc agttctgttg ctttataagc ttcattaata aagaccatca 2754121 gctgggaaat acccgtgttg aaacgaaggc cttcataatg gtctgtgact ttcatgaccg 2754181 tttcatgata gacgcgctcc aatgtttcac ccgcgccttc aacgattttt ccattaagct 2754241 caccgctgtc ttcaataaat aggcgccata cacggtcaag gaaacggcgc gcaccgtcta 2754301 atcctgattc agaccaggcg attgaagcat caagaggtcc catgaacatt tcgtacaatc 2754361 tcagcgtatc agcaccgtga gaggccacga tttcgtcagg attgacaacg ttccctttag 2754421 atttactcat tttttcgttg ttttcgccga gaatcattcc ttggttgtac agcttttgga 2754481 acggttcttt cgtcggcact acgccgatat cataaaggaa cttatgccag aagcgggcat 2754541 acagaaggtg aagcacggca tgttctgcac cgccgatata catatcgacc ggaagccatt 2754601 tttccaattt ttctggtgat gccagctgat ccggattgtg cggatcaata tagcgcaaga 2754661 aataccagca gcttcccgcc cattgcggca ttgtattcgt ttctcttctt ccttttttcc 2754721 ctgtctcagg gtctgtgact tccacccact ctttaatgtt cgcaagcggt gattcgcccg 2754781 ttccgctcgg tttgatttca tccgtttttg gcaaaatcag cggcagctcc tcttccggga 2754841 cagctgttga cgttccgtct tcccaatgaa tgaccggaat cggctcgccc caataacgct 2754901 ggcggctgaa gagccagtca cgaagacggt acgtcacttt cttctcaccg tttttcgttt 2754961 cttccagcca agcgatcact ttttcaatcg cttcctgttt gtgaaggccg ttcaggaaat 2755021 cagagttcac gtgctcgccg tcgccagtat aggctgcttc ctcaacgttc ccgcctttta 2755081 cgacttcctt caccggaagg ccgaatgttt tggcgaattc aaaatcacgc tcatcgtgtc 2755141 ctggaactgc catgacagca cctgttccgt atgatgcaag aacataatcc gcaatccaaa 2755201 tcggcagttt ttctccgttt acaggattga tcgcatacgc tcctgtaaat acgcctgtct 2755261 ttgttttcgc aagatctgtg cgttctaggt cactctttga ttgaatttct ttgatataag 2755321 cttcaacagc ttctttttgc tctgccgttg tgatgttttc caccaatgcg tgttccgggg 2755381 caaggacagt gtatgtagcg ccaaacagcg tatctggtct tgttgtaaac actgtaaagg 2755441 aatcatcatg tccatctata gcaaaatgaa cgtgagcgcc ttccgaacgg ccgatccagt 2755501 tgcgctgcat atctttaatg ctttccggcc aatcaagctc ttccaagtcc tcaaggagcc 2755561 tgtccgcata agcggtgatt ttcagcatcc actgcttcat tgggcgtctc tctaccggat 2755621 ggccgccgcg ttcgctcttg ccgtcaatga cttcttcgtt ggcaagaaca gtaccgagcg 2755681 cagggcacca gtttacaggc acttcgtcaa cgtaagcaag gcctttttcg tatagcttta 2755741 agaaaatcca ttgcgtccat ttatagtatt cagggtcagt cgtattgatt tcgcgatccc 2755801 agtcatatga gaagccaagc gcttgaattt ggcggcggaa gttatcaata ttctgcttcg 2755861 taaacacagc ggggtcgttc cctgtgtcaa gcgcgtactg ttcagctggc aggccgaatg 2755921 cgtcccagcc cattggatga aggacatcat agccctgcat gcgcttcatg cgggacagaa 2755981 tatccgtagc tgtgtatcct tcaggatggc cgacgtgcaa cccagctcca gacggataag 2756041 gaaacatgtc cagcgcgtaa aatttttgtt tttcattatt atcaagagtg gcaaatgttt 2756101 tgttttcaag ccaatatgtc tgccatttct tttctatctc tttgtgctga aaactcaaag 2756161 taaaaacctc cttctgattg aatacggcgt gtatggttca agtattgacg ggaaggagag 2756221 gattatattc agaatattcc caaactaaaa aaaactccct catcccaaaa agggacgaga 2756281 gactttcgtt ttcccgcggt accaccctcg ttagcgcggc atacgccgca ctcacttgat 2756341 acttttaacg cagttatgcg tcagcggctt ttcaccgctg caactctgag gtgagttcgg 2756401 aaacaaactt gattgacttt caccagccgt caactctctg caacaatatc tgtttcttac 2756461 tgctcctctt cattgttctt atcgcaaccg taatctaact gtattttata gaattctgtt 2756521 cataagtgca agcaggtttg tatacaatgg gaatgtaccc tgaacgggcg gagattgagg 2756581 acaattattc gggtggagtt ttggtttgac gtttggactc ggccggttcg ccgccgctgt 2756641 tcagttctct cacaaagtca aaacttctga gaacagcttc accgccgtag cctgagataa 2756701 tggataagat gacaagttga attcctgaat cggggtcagc ggataataca agtaaaatgg 2756761 aagccgtcat gccgataaac caatcttcca aaaatccaag gtagataaac cgcttcgtca 2756821 ttctgggctt ctccagcctg cctctctttt tcacatgacc gagaatcccc atgattcctc 2756881 caattacaca agcaatgagt acctgatgca gcatcttcat catcaccttc ctaaagccct 2756941 tatttcgtaa agcgacttca ggccatccag cccccttaaa cgattccgat gattttcgat 2757001 atctacatac cggcaaatct gtaaaaagct tgtttcttcc attatatgtg aacacatgat 2757061 cggtaagctt gatgcattgg attcattttt cacccagtga cattgaccta gtcacctatt 2757121 tagcatgtag aaaacctttc cgttcatatg ttcaaattct gttcttattt ttagtgtata 2757181 cgaggacaag ccctaatgac aaacaacaaa ctgcacttgc ttgaatcaga acatgtgttg 2757241 tgctacggtt actgtagaat tcatttttaa aaaggggaat atcaggcttt cgcatagcaa 2757301 gctgacggcc taagggggat ttatatggct agttttcaat catttgggat accaggacag 2757361 ctggaagtca tcaaaaaagc acttgatcac gtgcgagtcg gtgtggtaat tacagatccc 2757421 gcacttgaag ataatcctat tgtctacgta aatcaaggct ttgttcaaat gaccggctac 2757481 gagaccgagg aaattttagg aaagaactgt cgcttcttac aggggaaaca cacagatcct 2757541 gcagaagtgg acaacatcag aaccgcttta caaaataaag aaccggtcac cgttcagatc 2757601 caaaactaca aaaaagacgg aacgatgttc tggaatgaat taaatattga tccaatggaa 2757661 atagaggata aaacgtattt tgtcggaatt cagaatgata tcaccaagca aaaagaatat 2757721 gaaaagcttc tcgaggattc cctcacggaa attactgcac tttcaactcc tattgtcccg 2757781 attcgcaatg gcatttcggc tcttccgcta gtcggaaacc tgacagagga gcgatttaat 2757841 tccatcgttt gcacattgac gaatatctta tcaacatcca aagatgatta tttgatcatt 2757901 gatttatccg gattggccca agtgaacgaa caaacggccg accaaatttt caagctgagc 2757961 catttgctga aattgaccgg aactgagtta atcattactg gcattaagcc tgaattggct 2758021 atgaaaatga ataaactgga tgccaatttt tcgtcgctga aaacatattc aaatgtaaag 2758081 gatgccgtta aagtgcttcc gattatgtaa aaagatcccg ctcacccagc tggatctttc 2758141 agattgttga caaaatccta aaatggtttt cattttagga ttttgtcatc ttttcagcgt 2758201 gattgaaaac ccttgaagtc taggaaggac gagcatagga gcggagcgaa tgttctaatt 2758261 cgtgagcacc gaagcgcagg cctgacaacg aatgcgaggg tttgtcgaca cgctgaaaga 2758321 tcccgctcat tcggcgggat cttttattat gaagagattg atgcctgctt atttgtttct 2758381 ttagctgatt ttatccgttt gtcatataga agcgttgtgg caatactgat cagcagcaat 2758441 accaacagag ataaaacaag agccctaatg ccgtaatgat cgacaagcac tcctccgaac 2758501 aggggaccaa tcattctgcc gcctgtcgcc gcactgttga caaagccttg ataaaagcct 2758561 tctttccctt taggggcaag ctgattggca atagtcggca cagcaggcca aacaagcatt 2758621 tctccgatag tcaggatcac catcgcagcg agaaacatcg gaaattgctt tgcagtcagc 2758681 agcatgctga aagacacaat aaaaatgata aagccgatga ccatttgcgc ttttagcgac 2758741 tcggcccatt ttttcaccac aaaactgacg agcggctggc cgagcacaat gagaattccg 2758801 ttaaccgtcc acagcacgct gtataaggaa agagatattc caatgctttg tgtgtacgaa 2758861 gcaattgtgg ttgaccactg agaataagcc agccatccga gtacatagcc tccgcttaaa 2758921 atgatcagtg cggcaaattt tgctttgctg ttcacagcat cataatcaag cacggatgtt 2758981 tgggatgcat cgcccgtttg aatatttcga aatccgaaat atacaataaa gaaaaagatc 2759041 agatacaata cggcatttgc caaaaataca tatgaaaacg agaaagatgc cacgacaccg 2759101 ccaagcgctg aaccaacggc cacgcccgcg ttttgcgcga catatatcgc attaaatgcc 2759161 ttccttcccc cttcaggcca taccgatccc gccattgcgt agcttgccgg aaaaacaaca 2759221 ccggagccaa agcccacaat cgtcagcagc acaatatagg ctggccaatc atgaaaaaag 2759281 acaagaccca tcaggcttgc taacgtaatg gctatcccaa gcataatcga tttaaaaccg 2759341 ccgattttat caaacaaaaa acctccgcat aaattgccag ccacactggc gccggaattc 2759401 agcatcagga caagtccggc tactgttaac gactttccta aatgattatg gatataaatc 2759461 gtattcagcg gccataaaaa agaagcaccc gtcacattga taaacattcc aatgactaaa 2759521 attttaagag cacgcggcat actcatcccc ctttcttacc taaaaaagct catgaaaaaa 2759581 acgaaaccta aaacggctcc gtacgaatcc agttatcata gcacattcat tctatctgtc 2759641 tctctcacat ttttcaactg atgagcgtga aaaaatctaa caaatattgt ttgaaaaatg 2759701 taaaataaat agaaaaaggg gtcatattat ggaaatggta ttagcattct taggttttct 2759761 ggcatgtctc attgcactgg gctatggatt atatcacctt gtcagatatg tactgaaaaa 2759821 ggaaaaacgt ttctcaaaga gacttttttg gccgcttttc attggaggcc ttgtgctgct 2759881 ctttaccggg gcagcattgg cagaacctga cactgccgca gcaaatgccg agaaaaaata 2759941 ttcagcgcta aacgccgaat ataaaaacct cacaaaagag cacgaagaac ttgagaaaga 2760001 atataaatct gtcagctctg aagcaaagaa attaaaagac aacaaagaag atcaagacaa 2760061 gcttgagaag cttaaaaacg aaaatagcga tctaaaaaag actcagaaat cattaaaagc 2760121 tgagattaaa gagcttcaag aaaatcaaaa gcagctcaaa gaagatgcaa aaacggcaaa 2760181 ggctgaaaat gaaacacttc gacaagataa aacaaagctt gaaaatcaat taaaagagac 2760241 ggaaagccaa accgccagct ctcatgaaga cactggaagt tcttcaaaca atacgagtaa 2760301 aagtgatgaa accaaaacag ctgacaaagc agaaggctgt aatatcaaag gaagcagaaa 2760361 cggcatctac cacacgccag gcagtacata ctacgaccgg acaaccgatc cggctgaaat 2760421 gttttgctca gttgaagaag ctgaagccgc cggttatcgg gcgccaaaac gataaacaaa 2760481 aagctccaga atgtctggag ctttttctgt ttcacaacga cgatttaatg accttcttat 2760541 aataaagaac tgacagaaaa ccaaaaatgg agtagagcgc agtatataac accatcacca 2760601 taatcatagg cgcccatacc tctgatccga ataagaacca gccggattgg acggcaaagt 2760661 aactgtggaa gaggccgaca acgagcggaa tgccgaagtt gtacatttgt ttgatgcgta 2760721 tcccctttat caggtcgccc tgcgtaaagc cgagttttct taaaattgta tagctcggtt 2760781 tttcatcttc actttcaccc atttgtttaa aataaaggat acaacctgat gtaatcagga 2760841 acgttaaccc taagaagccg acgatgaaca tcaccatacc aaacagtgat ttttgcgcag 2760901 cgcttgtatc tagtcttgat aaatgctcgt ttttcttgtt cacctgttga aaaagctcat 2760961 ttgctttttc catttgatcg tcatgtttca cattgacgcc gataaatgta gattgcgcca 2761021 gctgaatgcg ggggtcttta tccttgtcca gctgtttaaa caggctgtca tccacaatga 2761081 cagcgggcat gcccccgctt gtaaacgtgt aggacacaag aaactcttct cttaatcctt 2761141 tatattttaa tggctgcgtc tcgtgcttgc tttttacttt aataacacca gagtccttga 2761201 aaaccattat tttttgcagc aagtcggtgt atcctgagaa aacggcttct ccagccgcca 2761261 catcgactcc ttttacatct ttgtcgctaa caacagcaag ctgcatattg ccgggatcgc 2761321 cctgcatctc tttcggagtt ccatccataa tatttgcaat gtcaacattt gcttgcagga 2761381 caggtgttgc cttttttaca aacgagatgt tgctttccct caatttgttt tcaaataact 2761441 tggcatcttt ctcattcatg aatgaaaaat cagccgctac attttgttca gcggtctttt 2761501 ccgacgagta atacgagatg taagcaagag ataacagccc gatggcgagc gctgaaacgg 2761561 ttgtaataat cgtcagcagc agcgcattcg atttcattct gaacatgatc gaagacagtg 2761621 acagaacctc agaaatattt aagtagccgc ccttgctttt tcgaatgata ttcgagataa 2761681 acgtaactga tcctttataa aacaaaaacg tcccgataat gacgctcccc agaatgaagc 2761741 tcatcgcaac aaacagttca ttaatggtct taaattttcc gccaaacagc tcagaagaca 2761801 catagtatcc tgtcaaaatc aacacgatgc ctaaagcgcc gatcagcatt tggaaaaatg 2761861 atattttctt cactttgtct tcagtggagg acgttacttt aaacaaagat aaaatactct 2761921 gttttttgat aaacgtataa ttcatgatca tgatcaaaag gtaaatgccg cagaacacaa 2761981 tgaccgtttg gaccaaggcc tgctcagaaa aatgcagttt cgcatccgct ttgacatcga 2762041 caattttgaa cagaatcatc aagacaagct tcgatatcga aaacccggcc gctaccccga 2762101 tcgctaatga accgaaatac agcatgacat tttctgcact taagatgcga aaaattttat 2762161 gcttcgtcat tccaattaat tgaaacagcc cgatttcttt actccgtctc ttaataaaaa 2762221 tcgtattggc atataaaatg aagatcgcca ctacagccac aagcaaaatc gaagcggttt 2762281 taatagccgc ggctcccttg attgaagcct tcacttcgtt aattgctgga tcatactgca 2762341 gcgtgacaaa ggcgaaataa agcgccacgc taaagatgag cgcaaacaca tacaaatagt 2762401 aattccggag attctttttc aaatttcgca ggatgagctg attaatgttc atgctgcacc 2762461 ccgcctaaca cgccttgcgt tttcataata tcctggaaaa acgtttgcct gtcctggccc 2762521 cctttattca gctgtgtata catttgcccg tccttaataa aaatgactct gccgcagtag 2762581 ctggcagcga cgggatcatg ggtaaccata ataatcgtcg cgttgcgttt ttgattgagc 2762641 tggctcagct tatttaatag atcggaggcc gatttcgaat cgagcgcgcc ggtcggttca 2762701 tcagcgaaaa taatgctcgg gtcatgaata aacgctcttc cagcggatgt tctctgcttc 2762761 tggccgccgg aaatttcatt cgggtattta tcccgcaatt catatattcc cagttccttg 2762821 gcaacttcct caaacttgcg attggcttcc ttttttgata gtttcgtgat cgataaaggc 2762881 agaaggatat tctctttcac tgtcaatgtg tctaacaaat tgtaatcctg aaagataaag 2762941 cctaaatgct gttttctaaa ttcagccagc tgcttttcct tcatagccgt catgtcattt 2763001 ccattaatat gaatggttcc gtgactgacc tgatcgattg aggacagaac gttgagcaaa 2763061 gtggtttttc ccgacccgga agcacccata atactgacga attcgccctt ttcaatgtga 2763121 atatcgatgc ccttcagcac ttcctgttta ttcagcttgt ttccataact ttttcgaatt 2763181 ttattcgctt ctaaaatcac catttacgca gtctccttta tattggataa tctcattata 2763241 aaaaggaatg ccgggctttt ccttcgatac ggcgaacaaa aaagaaaagc atgtgacatt 2763301 ttcgtcacac gcttatgaca tgttcaaatt gattccgtat tggaaaggtt aatgtaaaaa 2763361 ctgttcccgc accaaactcc gactcaacat caatatggat caataacggc gccgctgctt 2763421 tttttgccaa gtacagcccc atgccagttg acgcttgatc atggtgatcc gttgtggatg 2763481 taaacccttt atcaaaaata cgcggtacat cttttggatc aatgcccctg ccacaatctt 2763541 tcacttggag ctgcgtctgt tccccttttt gaaagctttt gatctcgatt tcagaggctt 2763601 cgctgtattt caccgcgttt gtcagcagct gcctgatgat aaacgccagc cattttgcat 2763661 cgctcagcac ttctttggcc tcgagctgta tgtcaaaacc gatccctttt tggatacacc 2763721 acgattgtaa atctttgatt tctttaaaga tcaaaggctg aagctgaatg aattctactg 2763781 acaggtcgtt ttcaataaat gaaatgcgtt tttgatgaag ctgctgatca agaagcaggt 2763841 gaatacgcag ccattcatat gacagctggg atttcagtgc tttttcttcc attctatcaa 2763901 tgattaaatg catcgctgtt aatggagttt tgacctcatg gatccatgcc atcagctcat 2763961 ctttttcatt ttccaatgct aagcgatgcc gtgctgcggt ctgcttcaag tgttctgttt 2764021 gcccggcaat gcttctttca accattgctt caaacggcgt ttccggttca tttatggctg 2764081 tcacatcgag attgttctcc catgttttca agcttttata aaacgctgtt tctttccgat 2764141 agcggaacca aaggaatatg ataaaaaaca agatgcacaa atacaccata taaagtacat 2764201 tcccaaatga tatggaagga tcgacaaaag caatgaacag catcaaagcc tgctgaaaca 2764261 aaaacgcggc aatccagctc cgcctttcga taaggaatgc tttaatcata gaacttgtcc 2764321 tcttccttcg cgatgtagcc ctggcccacc tttgtctcga tatatgcacc aagctgcagg 2764381 gcgtccagtt tttttcgcag gcgattgaca ttgacggtca gcgtattatc actaacaaaa 2764441 cgctcatcgt tccacaagct tctgatcagc tcttcccggc tgacgatctt gtttttttgc 2764501 tctattaatt gttttagaat gaacatttca tttttggtca gttcaacaga tcctttgtca 2764561 ttgctgacga ggttctgctc cgcgtctaca gcagcgccgc accacgtttt aatcgtactc 2764621 ggctccgtat tataatggtg cacacgccgg aacatcgctt ggattttcgc gatcagcaca 2764681 tcaaaatgaa atggcttttg aataaagtca tctgccccga gctgcatgga catcaccata 2764741 tcagcaggat gatcccggga ggataaaaag agaatcggaa catttgaccg ggagcggatc 2764801 agacggcacc aatgaaagcc gtcaaattta ggcagctgca catcaataat gacacaatca 2764861 ggattaaccg ccgcaaattc ctgcagcacc tgactgaaat cctgaatgcc gtatacatca 2764921 taggaccatc ccgttaaacg atccttgatt tcatgaaaca gcgattcatc atcttcaatc 2764981 agcaaaagtt taaacaatcg actcaccgca ctttttcctt ttttatcaag tgtatagcaa 2765041 aacgccagca tgcgctatag aaaaagccgg ctgtctcagc cggctcgttc gcattataat 2765101 tctcttctca acgctgtcag cacgttggtt ttggtagctt ttctcgccgg gttcattccg 2765161 gaaatgactg cgacccctcc gcaaatcaca acggcaatga tcacaaggct cgccgggatg 2765221 taggagaatg tgtaattcaa atcgcccgca tcgccaccgc ttgtggccgc aagaatcatc 2765281 ggaacggcca ggttgacaag gtagctcacg ccgtaagaaa tgataatccc aatcacacag 2765341 cctaaaattc cgatatacgc gctttccatc aagaacattc ggcgaatgat tgacgggctc 2765401 gccccaatcg ctttcataat gccgatctct tgcgttctct ctgtcaccgc catcgtcatc 2765461 gtgttaaaaa tgccgatcgc tgaaatgata actgcgatac atccgacaaa gatcagtccg 2765521 attttgaaga ccatgaagaa ggtattggct ccctcaagtt cagtagtcac tgatgtgaca 2765581 tagtacccgt catctgttag atcatttgtc agctgttcca cattctcaaa cttatcagca 2765641 aaaacaccaa tgttcgtttc aacatttccg cctttgaaat ctaagaattc cgaaaaatct 2765701 tttttgaatt gatcactgat aaaaatattt gagtcctcca tccagtcttg agatggtttt 2765761 tttgtaatac cgacaatttt aaagtcatat gtttttgttt ttgtaacatc ccctgtttta 2765821 gaatctgtct tcgatacact tagttcaatt gttttattta gaatatcttt cgtatagccc 2765881 tttggttctt ttatatcttc tggatttcct tttgcttcct cgattttttt gttatattct 2765941 tccgattctt ttttcgttaa taatctcttt gcgaagtcgt atcctactac gatttcattt 2766001 tccgactttg cgactcttcc cttttccaat tccatattgg cctttaattc atcattcata 2766061 ttagtaaaaa tgagatttga gctttcattt gtacgattgc ctaaagtagc tttgtttggt 2766121 tcatacactt gcgttctttc tacaactgac cttacgtgat catacttctc taaatcagct 2766181 tttttaatcg gcttgtctcc ttccttgccc attacgctga ctttcgttac aatctgctgg 2766241 ctcattgtca tatctgtaat cgtcttttga atcccaaatc caacggacga caacacaacc 2766301 aaaaacgcac acgccattgt tgtcgccaga atcgtcataa agacgcgaag cctgtttttc 2766361 ttcatatttc ttctgataaa atgaacctga tccttaaacc tcaacggtaa ttcctccttt 2766421 tagcacacca tcatgaagct gaaattttga atgtccgata gaagcgactt catcatcgtg 2766481 agtaatgatc acaaatgtaa tgccacgctc acgattcagc tgctggatca attccagcac 2766541 ttcatgttcc gtttctgaat caaggcttcc cgtcggctca tccgctaaga taatcgaagg 2766601 atttaaaatc aatgctcgag caatactgac acgctgctgc tggccgcctg acagttcatt 2766661 cggataatga gcggcgtggt tttccagacc gacgcgtttc agcatgtcct gcaccttttg 2766721 cttccgctca gatggcttga ttccttttaa cgccagcggc atttccacat tctcatacgt 2766781 cgttaaaccc gggatgagct gaaagctctg aaaaataaac ccgaaatggt caagccgaaa 2766841 ttgcgcccat tccttttcat taaaccccgt aacatcagtg ccattaatga caatccgccc 2766901 ttttgtcggc gatatgtagc cggaaattaa attcaaaagc gttgatttcc ctgagccgct 2766961 tcgtccgaca atgcaggcga tttccccttt cgccacgctc aatgaaacat ccttcaatac 2767021 tggaacttca ttctcacggc ccttttttcc gatcgtgaaa gaatggtcga tatgctgaac 2767081 atcaatcata tgttctctct cccttacaaa agtttcattt ttttataaat cgcaaaataa 2767141 ctaatcaaga aaccgattac cgcacctgta cccatgccaa tgagataacc ggcaaagctc 2767201 tcgcttgcag taaatccaaa atagccgaag cccatgattc ctatgataat aacgatgatc 2767261 tgcaccgggc ggttaagcgg cttccataag aagaaatatc cgtttctttc attagacatt 2767321 ttaacaaagc taatatagcc gatgatgtaa aaaatgatag tcatgatagc cggaatgact 2767381 aaataatatg gtgaattctc agcccatttc gagtctacat aaattatcgg aatgaaatac 2767441 tgcacccatt taggtactgg accatggata aaatctattg atccgccaaa aaggatctcg 2767501 aggttgatca caggcaggct gatgagtaaa aacggcgaaa tggccacggt aaatgagact 2767561 agaagctgtg cgaaactatt gcctgtcaaa gctcctccgg ccataaccaa agaataagcc 2767621 agcatgctaa caataatcat tcccaagctg taattgtgaa aataaacggc ctgatctggc 2767681 ttcaaaagca tgatcagcaa aacagacaaa acataaccta tgagctgcgg caccacaatc 2767741 accattccgc cggtaaggaa cttcgcatga aatatctgcc ctcgtgtata tggaaggctt 2767801 aatgtaaaat caaagaagct cttgctacgt tcaatcccaa gctggctgac cgccaaaacg 2767861 actccccaaa tccaaaacaa tgagataaat gagctattta aataatcaac gctgaatacg 2767921 caggggccga cccaattttc ttttccagtg acacagcctt gatagatgag atacatattt 2767981 aaaattgata atggattacc taatataaaa accaaaatgg tgataactaa ggcgacttta 2768041 ttctgccgcc actctttgta aagcagtccg gaatccggca actcacttcc ctccaaacct 2768101 aaggcatttc ttacactttt gttttcttat aaatagagaa gtagctcaca aagaatccag 2768161 ccactgctcc aatgatcata cccaaaatat aaccaataat ggaatgtccg gtatagtatc 2768221 caaataaacc aaatccaagg atgccgaaag ccataaccag aatttgcacc gggcgatcta 2768281 atctgttcca taagaaaaag tgtccgttcc gttcacttgg aagcttcttg aagcttataa 2768341 agccaatcaa gtaaaatagc atgctcatta cggctggaat caataaaaga tatttactgt 2768401 taatcagcca ttcatttaca acgtaactaa tcggtactag gttcgataaa ttgcttgcca 2768461 gagagaaata actctcaggg gaagggaata tttcccatat attcgcacca aaaacaactt 2768521 ctaggtttcc aaccggcaat gcaataatta aatacggcaa tatagctgct gaaaacgccg 2768581 ttaacagttg ggcaaaagca tttccagtta acgctccggc ggccatcacc agtgaaaaag 2768641 ccataaaact tatcacgatt actccaatgc tgctgtgctc aaaaaagtag acgtgttcag 2768701 ggttatagac aagaatcagc agccatgcaa gtaaaaagcc aatcaattgt gacagcacaa 2768761 tcacaaaacc gcctaaccaa aattttgtct gaaaaatttg gcttctgtta tacgggaggc 2768821 ttaatataaa atccatcgtg cctttcgaac gctccattcc gaggaagcag accgccaaaa 2768881 tgacacccgg cacccagttg atatctatca gattgcttat ggaataattc acaataaaat 2768941 cacaatattg cgggtcttgg cgatcaagac acccttgata agacaaatac gtattaacga 2769001 tagaaagcgg atttgccaat actaaaaacg cgatacttaa caaaatcacc acttgattct 2769061 gcttccactc tcgatagagg agacctcggt ctaccatctc cgcttccctc caaacttcgc 2769121 aatgaacact tcttccaggt tgacaggaag ctcattccac acttttggct tcagctctct 2769181 caaaaagctc tttttctcct catcgctttt cggaatcagc actgtgtaaa acacgccggc 2769241 ctgatcgagc atcggaatgt tttgctctct gatggccaaa ttgacatctg tatcgaaggc 2769301 catttgaatt ttaatgtatt cttcttttaa ctcatcaaga tccatgacgt tggtcaggct 2769361 gttatcttca agaaaaccaa ttcggttgca catccgctct atgtcttcaa gccggtggga 2769421 cgtaatcagg atgctcgtat cacgctctgc cacttcatcg accatcagct gcagcacatc 2769481 atgccttgtc accgcatcaa taccatccgt cggctcatca aggaggatca gcgccggtct 2769541 cgccgcaaac gacagaacga gcgatagctg cttttttaag cctgtcgaca gctcacggta 2769601 ttttttcgtt tccggaattt cgtatctgtt catcagctca ttcgcgtacg tgacatcaaa 2769661 tttcggatat attcttctca aaatatcgac taactgcttg tatgtatact tatcgtaaaa 2769721 cggattttga acaggcatgt agatgatatt ttgtttgact ttcgggtgct ttttgatttc 2769781 tacgccgtca aataaaatcg ttccgctgtc agcgaaaatg atttgctgga ttaagcgaag 2769841 catcgtcgtt ttgcccgatc cattgcgtcc aagcaatcca aagatttctc ctttttcgat 2769901 tgttaatgaa acatctttta atacttgatt gccgtcaatc gcttttgaca gctgccgcag 2769961 ttcaatcatt ttttttgcct cccttcacat cagcgctgat ttcctttatc cattcgtgca 2770021 gtttttccag ctcaacccct gcatagtgtg catcgatgat gagctgtttg agttgctctt 2770081 taatcatcgt catcttccct tcaaccagtg tcgtttttgc attctccgat atataggtcc 2770141 ctctgccccg cagcgtttca ataatcccct ctcgctcaag ttctttatac gctttgctga 2770201 cagtgttcgg attcgcaata atgatcgttg ccaattctct gacagaagga agcttatcac 2770261 caggcttcat gatccctttc aaacaaagct ctttcatttg ctgaataatt tgttcgtaaa 2770321 tgggtgttga gcttcttgga tcgatttgaa tcatttactt ccctactttc tatacgatct 2770381 gaacctttta tagataaaaa tgatcaatta tacttttttg ccattcaaaa ccgatcatca 2770441 caagaacaag aaaaaaagaa caagcgatca cagatgccgc aatcagcatt ggcacgttac 2770501 gtttgtttcg ttttttatgt ttcataactg cctcccttaa tgtcaatata taaatgattt 2770561 tatattagtg tctatagtgt attacttcaa ttagtacact taatacaata aatactttga 2770621 ctcacaaagt caatcctttt tttacaaaaa aacggaccct tttaaaaggg tccgttttcc 2770681 tacacatcaa gagggtgctg caggatcata ttattttgca aagattgaag ctgaagtctc 2770741 attctgtaca gctgttctct ctgctgatca tttgacgaca gccatagttt attcaaggca 2770801 tttaccgcat cttctagctg catttgtgca tcactatatt cttgatcgtt ataatgctct 2770861 tgtttagaag cgattttcag ctgttcttca gcataatcat aggcctgcat acattgctgg 2770921 agatgttcat ctactgattg tcttgttgcc acagtaaccc ctcctcttgg taatggaaat 2770981 catccatcat tcatattgta gcctcatctg actttattca ataaagtaat ttatggtcga 2771041 tattcatttg ttctcttgtg aaatgcgtgc tacaatttta ggatgcaatc gtacgcaagg 2771101 aggcacatga attgtgatgc agaacaatcc ttttccttat tcaaatacgg aaaaacgcta 2771161 tcatacattg aattatcatc tcagagaaca tttcggccat aaggtgttta aagtagcgct 2771221 tgacggcggt tttgactgtc caaatcggga tggcaccgta gcccacggag gctgtacgtt 2771281 ttgcagcgca gcaggctccg gagattttgc tggaaaccgg accgatgatt taattacgca 2771341 attccatgac atcaaaaacc gcatgcacga aaaatggaag gacggcaagt acatcgctta 2771401 ttttcaggct ttcacaaaca ctcacgcccc ggttgaggtg cttcgtgaga aattcgaatc 2771461 cgtcctcgcc ttagatgatg tggtcggcat ttcgatcgcc acacgcccgg actgtctgcc 2771521 tgatgatgtc gttgattact tggcagagct gaatgaacgt acgtatttgt gggtggagct 2771581 tgggcttcaa acagttcatg aacggactgc acttttgatc aaccgcgcac atgattttaa 2771641 ctgctatgtg gaaggcgtca ataaattaag aaaacacggc atacgtgtct gctcgcatat 2771701 tatcaacggg ctgcctttgg aagaccggga catgatgatg gaaacggcaa aggccgtcgc 2771761 agatttggat gtccagggca ttaaaatcca tctgcttcac ctactgaaag gcacgccgat 2771821 ggtcaaacaa tatgaaaagg gcaagctgga atttctttct caagatgatt atgtgcagct 2771881 cgtctgcgat cagcttgaga tcattccgcc tgaaatgatc gtccaccgca ttacaggtga 2771941 cggaccgatt gagttgatga tcgggccaat gtggagcgtc aacaaatggg aagtgcttgg 2772001 cgccattaat aaagagctag aaaatcgagg cagctatcaa ggaaagttct ttcaacggct 2772061 tgaggaggaa tcagcgctat gattttgaag aaaattcttc cttacagcaa agaactgctg 2772121 aaaatggccg cgggagaggg agatattgtc gtagatgcga caatgggcaa cggacatgat 2772181 acacagtttt tagcggagct tgtcggtgaa aacggccatg tatacgcatt cgacatccaa 2772241 gaatcagccg tggccaatac aaaggaacgg ctcggtgaca tgtatcaagc gcgaacaacg 2772301 ttatttcaca aaagccatga taaaatcgct gaatccctcc cgcctgaaac acatggcaaa 2772361 gtggcggccg cggtatttaa cctcggctat ttgccgggcg gggacaaatc aattacgaca 2772421 aacggcagtt ctacgatcaa agccattgaa cagcttctca gcatcatgaa agacgaaggt 2772481 ctgattgttc tcgtcgtcta tcatggccac ccggaaggca aagctgaaaa aaacgacgtg 2772541 ctcgagtttt gccgggactt ggaccagcaa acagcccgtg tattaacata cgggtttatc 2772601 aatcagcaaa atgacccgcc atttattgtc gccatcgaaa aaaaagctca gatcagcaaa 2772661 tgatttgagc ttttttcttt gaatttttca tccaggacat tttttgaaat ttccggtagg 2772721 ctctgccgtt gatataaaag aaaagggagg tttttccgct ggctttgatc agcttctttg 2772781 cgagccggcc catttccttt tggcctgcca ctttatcatc tgacaaataa acgccaagca 2772841 agccgcgatt gattaaacga tggaagtttt catgcggaat gccttgtaaa tgctcgtcgg 2772901 ctttatggat aaagtgttca agccggtcca tcatctcttc atgagactga taatacgagc 2772961 agaaattcaa gtctccttcc agcaagtcct cctcttgatc aatcaaataa tcaagaagaa 2773021 tatgaagacc ctgtatgtaa ggaaaataac tgtctcggat ttttttagcg gtgctttctg 2773081 tgaaatcagg ctggaacgaa tacgcaacca gacagaaaat gcctaacgtt gagcctgcac 2773141 aggctgaaaa ttcataccat tccatctcag gcagctctga ttcatattga gtaaaccact 2773201 tttcaagccg cggaacacgc tcatgctcaa taacgtgctt atgcacctgc aaatcgcaat 2773261 aatagccgca cagttcaagc agataaggtt taatcatgtc atagtgctca atggagccga 2773321 gaacacgctg gcacgtttta accagttcat gcaaatatcc gctgtcatcc tgttcttccc 2773381 tgaattgata atagttttgc agttccgccc caactgtcag tgcgtcctgc attgaggcat 2773441 ggagcatccg aaaatcctgc gggtccagcg aggtgctgcg gtcacacaga ttgtccaaat 2773501 aatcactaat cgtttgatac gcgatgataa actcgacaca tttctgcttt tggctgcctg 2773561 acaataaggc cagtatgccg ccgccttcac agtgaaacgt tttgtcccga atacttgcgg 2773621 ttgcctgtgc tttcaattca ctgttatgaa tcgattctga tttttgcttc catatgtcca 2773681 gctcttgatg aacgagcgga aaaatatctc gatatacctt tgccatcaat ccaaaaggat 2773741 gttccggtac tgtcaacaca tgcaccccct actagttcaa atatattgat cagtaaacgc 2773801 tcttgctgct ttaaaaacat cttctctctc gggttcattg aagatctcat ggtaaagccc 2773861 ttcccactct ctgtatgctt tattatgaga agcaacacca ttaaaccact tgatgaccat 2773921 cgttttgtca acaagcttgt catcaccggc ttgcatcaca agaagcggaa ctttcaaaaa 2773981 tgcctctgtc ggcaccattg ccgattcaat tgtctttaaa agctctctgt accatctgac 2774041 agaaactttc ctgacgtata acgaatcatt ttggtcagct tcgatgacgt cctcattgcg 2774101 cgtcgccata tcaattgata atcccgaatc aaccttaagt gacggagcga tgacattcag 2774161 gccttttgat gcaagatcaa gcgctttatt cactttaatt tgcagtccga gacacggtga 2774221 tgataaaata attcccgtaa tccggggatt tctttgctgt ttaacccatt caatcgcgac 2774281 cagaccgccc atgctgtgac ctagaagaaa aaccggaaga tcaaaggttc gcgctttatc 2774341 tatccaagca tctacttcat caatgtattc ttgaaacgag cgaatatgcc ctctcgctct 2774401 tgtcgttgtt ccctgtccag gcaaatcgcc catgacaacg tgataacccg aagaccgcca 2774461 catttcaatc agccatttat atcgtccgtg atattcactt gccccgtgaa tgattacaat 2774521 cacggcaaca ggtctgtctg ctttccaggt ccacatgatc ttcacctcat acgaaattta 2774581 aatagagaaa gaaggatgaa tcttatgatc tacccttata aggaacacaa gccagatatc 2774641 cacccaacag cctttatagc tgataatgca acaattaccg gtgatgtcgt gatcggagaa 2774701 cagtccagca tttggttttc tgttgtcata aggggagatg ttgcgccgac cagaatcgga 2774761 aacagagtca atatccaaga tttaagctgc ctccatcaaa gcccgaacaa gacgctactc 2774821 attgaagatg acgccacgat aggccatcag gttacacttc atagcgctgt tatccgcaag 2774881 aacgccttaa tcgggatggg ctcaatcatt ttagacggag ccgaaattgg cgaaggcgct 2774941 tttattggtg ccggcagtct tgtcccgccc ggaaaaatca ttccgcctgg ccatctcgcc 2775001 tttggccgcc ctgcaaaagt catccgccct ttgacggaag aagaccgaaa agatatgcaa 2775061 agaatacggt cagaatatgt agaaaagggc caatattata aatttcttca acaaacataa 2775121 gacctgcttc gtcttacttt accatttttc aaattatatt tgaaagcaat aaccatcgtt 2775181 aacccggacg tcatacagtt cgggtttcga tttttccata aaacgttcac atatagcatg 2775241 aaacgtatga cttttatctt atcacaaaac tataaacagc ctctgcaaaa acacatacct 2775301 attctttcct gttctctatt ttctatgagc acacacaaaa agagcccact gggagctctt 2775361 tttgtcagct gatatttcgt tcgctggcag cagccgcatt ttttttatga aacccttttc 2775421 catagtacac agccagcaag atgagaaacc atatcggccc gataatcacg gctactcttg 2775481 tatcagggct gtaagccata agaatgacga cgaatgctag aaatgccaat gacacataag 2775541 acgtaaacgg aaataaaggc attttgtact ttaattgttt cttttcttcc ggcttcaaac 2775601 ttttcctgta ttttatttga gaaagcaaaa tgattgccca cgtccaaatc gctccgaacg 2775661 tcgcaatact tgtaacccaa gtaaatacct tcgcagggac aacatagttt aacagcactc 2775721 cgactaataa agcgcccgct gaagccagaa cagctttacc cgggatgccg cctttcgtca 2775781 gctgaccata tgcttgtggc gcctctttct gttccgccaa gttaaacagc atccgccctg 2775841 tgctgaaaat accactgttg catgaagaca gcgcggctgt caacacgaca aagttaatga 2775901 tacctgcggc cgatggaatg cccacttttt gaaatgtgag aacaaatgga cttccttgag 2775961 agccaatttc ctgccacgga taaatagaca taatgacaaa taaagcgcct acataaaaaa 2776021 tcaaaatccg ccaaaatact gtatcgattg ctttggctaa cgatttttgc gggtttttta 2776081 cttcgccagc cgtcaccccg atcatttcaa tccctaaata ggcgaacatg accatttgaa 2776141 gagacaataa aacccctttt aatccatgag ggaaaaatcc tccgttgttc cacaaattgc 2776201 tgattccggt tgcaatgccc ccattgccga ctcctgcaat aatcatcaat aaaccgacag 2776261 caatcatgga taagattgca acaattttaa tcaatgcgaa ccaaaattcc agctcgccgt 2776321 aagctttgac agccaggaaa ttaacacccg tcataatgac cagtgccgat aacgcccaaa 2776381 tccagtttgg cacgtccgga aaccagaacc ccatatagat gccgacagca gtgatttcgg 2776441 ccatacaggt gacaacccat aaaaaccagt agttccaacc tgttaaatag cctgcaagcg 2776501 gtcccaaata atcacgcgca tacctgctga aggagcctgc gaccggtttt tgaatggcca 2776561 tttccccaag cgctctcata ataaaaaaca tgaccaggcc gcttgcggca tacgctacca 2776621 aaataccagg ccctgctaat tgaatagctg atgcggagcc gaggaacaac cctactccta 2776681 tagcagctcc taaagacatt aaagaaatat gcctttcttc gagtccgcgg tgcagctctt 2776741 gtttttgttt ttgcatgctt cttctcccct agaaaaaaat atcattatat catttttctg 2776801 aatattccgt acggattggg taaatcaatg atgatggaga aataaaagga taacaacaag 2776861 gctttcgact actcgaaagc cttgttgtct gttacacaaa gatgacttct ttaggctgat 2776921 ggctcagctc ttcaggcata taccgttttt caatattgat gctgtgccag atcataaaga 2776981 ttagcacagt ccaaatttta cggctgttat cagccttgtc cgcacaatgg tcttcaagaa 2777041 gctgaaggac ataatcctta tggatataag catccgtttg gctttcttga ataatattcc 2777101 gcacccattc gttcatttcg tttttcagcc aatgacggat cggtacaggg aaaccaagct 2777161 ttttgcggtt taatacgtgc tcaggcacaa ttccttcagc ggctttgcga agaagatact 2777221 tcgtcgtgcc gttcttcgtt ttcagctcat caggaatttt tgaagcgacg tcgaatacga 2777281 ctttatccaa gaacggcaca cgcagttcca aagaattcgc catcgtcatt ttatccgcct 2777341 ttaacaaaat gtcgccgcgc atccaagtgt ggatatcgac atactgcatt ttgttgatat 2777401 cgctgtacga gctgctttct gtaaagtaag tcttcgtcac atcgcgatat gaaaggttcg 2777461 gattataatg cttcaacagc tgctttttga cagactcttc aaagattttc gcgttaccga 2777521 tataacgatc ctgaagcgga gtgcagccgc gctcaagcag gctcttccct ctcatacctt 2777581 caggcataac ggcagcaacg tgcagaagca tctttttcaa gccggacgga atccgttcaa 2777641 acggtttaag cgaaagcggt tcacggtaaa tgttatatcc gccgaagagc tcatccgctc 2777701 cttcacctga taaagcaacc gtaacatgtt tttttgcttc ttttgcaaca aagtacaacg 2777761 gaatcgctgc cggatcagca agcgggtcat caaaatgcca tacgatcttc ggaagctcat 2777821 tcatgtattc ctcaggcgaa atgactttgc tgatattttc aatgcccagc gccgctgccg 2777881 tttctttcgc tacatcaacc tcactgaagc cctgctgttc aaagccgaca gagaatgttt 2777941 ttaagcttgg atgaaattcc ttcgcaacag acacaataaa ggaagaatca atcccgccag 2778001 acaggaacga accgacagga acgtcacttc tcatatgaac gtttacagag tcatagatcg 2778061 cgtctcggac ttctttcaca agcttgtctt cttcagtctg aaccggcttg aagttcgctt 2778121 tgaaatacgt tttgaatgtg atatcgccgt ccgggcggat tgtgaattgt gaacccggct 2778181 ctactttttt cacatgggca tcaagcgtgc ttggttcagg aacaaattgg aaagacatgt 2778241 actgctgcaa tgcctcttta tctatttcaa tatcattctg agcaaccatt aaactttttc 2778301 tctctgaggc aaaataaacc tgatcattga tcgttgtgta gtacaacggt ttaatgccga 2778361 atggatctct tgccccataa agcacatgat cgtttttatt ccaaatcaga aaggcaaaca 2778421 taccgcgcag tttggacgcc gcttcttctt tatagtgacg gtaagtcgca agaagaacct 2778481 ctgtgtccga atccgtgttg aatgtgtacc cctttgcttc aagttcttct ctcagttcga 2778541 tatagttata gatttctccg ttaaagataa tccaatatgt ttcatcttca tatgataaag 2778601 gctgtccacc attttctaca tcaataatgc tgagccgtct gaatccgaag ccgacgtgct 2778661 catcatggaa atatccatca ctgtcaggac cgcggtgaac gatcatttgg ttcatttgtt 2778721 tgattagttc ttcttgatca gcggtttgag ctaacggatg cttgttaaaa accccgacaa 2778781 atccacacat agtattgcct ccataattaa aattgtcatc attgaacccc tatttataga 2778841 cgctgtgaat agtatttggt ttcacagtta tgtaaaaaaa taaacatgaa tacaacgata 2778901 aaaaagggaa agccgcttaa ccagtaagcg gctataaaat tattctccta acgcttcttt 2778961 acgcagctgc tccgctttgt ctgtgcgctc ccatggaagg tcaacatcgt gacgtccaaa 2779021 gtggccgtac gcagcagttt gtttatagat cggacggcgc aaatcaagca ttttgataat 2779081 gccggcaggt cgtaaatcaa agttattgcg aacaacttca atcagttttt cctcagaagc 2779141 ttttcctgaa ccgaatgtgt tgattgagat tgacacaggc tgtgcaacac cgatcgcgta 2779201 agcaagctgt acttcgcaag aatcagcaag ctcagccgca acgatgtttt tcgcaacgta 2779261 tcttgccgca taagctgcag aacggtctac cttcgtcgcg tccttacctg agaacgcgcc 2779321 tccgccgtgg cgtgcatagc cgccgtacgt atcaacgatg attttgcgtc ctgtaagtcc 2779381 cgcatcccct tgagggcctc cgattacgaa acgtcctgta gggttgatga aatattttgt 2779441 ttcttcatca atcagctctt caggaacaac cggattgatt acatgttctt taatgttgcg 2779501 ctgaatttgc tcaagtgtaa tttcagggtg atgctgagtt gaaataacaa tcgcgtcaat 2779561 gcggactggt ttgttatttt catcgtactc aaccgttacc tgtgttttgc cgtcagggcg 2779621 aaggtacgga agaatatctt ctttacggac ttcacttagg cggcgggcta atttatgggc 2779681 aagtgaaatt ggaagaggca taagctcttt cgtttcgttg cacgcataac cgaacattaa 2779741 tccttggtca cccgcaccaa tcgcttcaat ttcttcgtcg ctcattgtgc cttcacgggc 2779801 ttcaagcgct tggtctacgc ccatcgcgat atcagcagac tgctcatcaa ttgatgttaa 2779861 aaccgcacaa gtttccgcat caaatccgta ttttgcacgt gtgtatccga tttctttaat 2779921 ggtttggcga accgttttcg gaatgtcaac atacgtagaa gttgtgatct ctccgcttac 2779981 aagaaccaaa cctgttgtca cagatgtttc acaagcaaca cgcgcgttag ggtctttctt 2780041 taaaatttca tctaaaatgc tgtcagaaat ctggtcacag attttatccg gatgcccctc 2780101 cgtaacagat tctgatgtaa ataaacgacg atttttactc atgatttgct tcctcctgca 2780161 caaggcctcc cgaaagacct tgtatatatg atacggaact cgctccctct tatacaatgt 2780221 acagttatat tagagaatgt taattggcat atttatgaaa taaaaaaacc ttttccatcg 2780281 aggaaagggt ttggtctttg tgcctttcac tcttatcgct caaggaatca tacaaccttg 2780341 caacaggtta gcaccttggt tgtctcactc agttgaacat aataaataac agagaaaccg 2780401 gttgctgggc ttcatagggc ctgtccctcc gccagctcgg gataagagta tccgctcaat 2780461 gaaatatctt atcgtaaaag ggtttgcaat gtcaatatga ttcagaagaa ataggcacct 2780521 atattgaggg aaaacaatgg aaatgcacac acaaaaaaca ataaatagta tagactattt 2780581 gaaaatatat gttatactaa ttcacaatta gcaaaacaca aaaaacgata aaggaaggtt 2780641 tcatatgaac tcagttgatt tgaccgctga tttacaagcc ttattaacat gtccaaatgt 2780701 gcgtcataat ttatcagcag cacagctaac agaaaaagtc ctctcccgaa acgaaggcat 2780761 tttaacatcc acaggtgctg ttcgcgcgac aacaggcgct tacacaggac gctcacctaa 2780821 agataaattc atcgtggagg aagaaagcac gaaaaataag atcgattggg gcccggtgaa 2780881 tcagccgatt tcagaagaag cgtttgagcg gctgtacacg aaagttgtca gctatttaaa 2780941 ggagcgagat gaactgtttg ttttcgaagg atttgccgga gcagacgaga aatacaggct 2781001 gccgatcact gtcgtaaatg agttcgcatg gcacaattta tttgcgcggc agctgtttat 2781061 ccgtccggaa ggaaatgata agaaaacagt tgagcagccg ttcaccattc tttctgctcc 2781121 gcatttcaaa gcggatccaa aaacagacgg cactcattcc gaaacgttta ttattgtctc 2781181 tttcgaaaag cggacaattt taatcggcgg aactgagtat gccggtgaaa tgaagaagtc 2781241 cattttctcc attatgaatt tcctgctgcc tgaaagagat attttatcta tgcactgctc 2781301 cgccaatgtc ggtgaaaaag gcgatgtcgc ccttttcttc ggactgtcag gaacaggaaa 2781361 gaccaccctg tcggcagatg ctgaccgcaa gctgatcggt gacgatgaac atggctggtc 2781421 tgatacaggc gtctttaata ttgaaggcgg atgctacgct aagtgtattc atttaagcga 2781481 ggaaaaggag ccgcaaatct ttaacgcgat ccgcttcggg tctgttctcg aaaatgtcgt 2781541 tgtggatgaa gatacacgcg aagccaatta tgatgattcc ttctatactg aaaacacgcg 2781601 ggcagcttac ccgattcata tgattaataa catcgtgact ccaagcatgg ccggccatcc 2781661 gtcagccatt gtatttttga cggctgatgc cttcggagtc ctgccgccga tcagcaaact 2781721 aacgaaggag caggcgatgt accatttttt gagcggttac acgagtaagc ttgccggaac 2781781 cgaacgtggt gtcacgtctc ctgaaacgac gttttctaca tgcttcggct caccgttcct 2781841 gccgcttcct gctcacgtct atgctgaaat gctcggcaaa aagatcgatg aacacggcgc 2781901 agacgttttc ttagtcaata ccggatggac cgggggcggc tacggcacag gcgaacgaat 2781961 gaagctttct tacactagag caatggtcaa agcagcgatt gaaggcaaat tagaggatgc 2782021 tgaaatgata actgacgata ttttcggcct gcacattccg gcccatgttc ctggcgttcc 2782081 tgatcatatc cttcagcctg aaaacacgtg gaccaacaag gaagaataca aagaaaaagc 2782141 agtctacctt gcaaatgaat tcaaagagaa ctttaaaaag ttcgcacata ccgatgccat 2782201 cgcccaggca ggcggccctc tcgtataaaa aacaaaagcc aagagcaatt atgctcttgg 2782261 cttgttttaa ttgacggaat gcaaagaagt cagcttgtat gtaatgatgg tccggccttc 2782321 ttcccattga agcttctgca cttcagctgt gcctgacttt tcgccaaact ttgttttgcg 2782381 tacatccatt ggaatctcca tcggatatac tcggtatccg tccttctcta acgtgaatat 2782441 attttcatct atgcgaactt cttttccttt tgtcacaatc agtgtattaa attcaacagg 2782501 cattcccaaa gtgaaatccc ctttcgttct cttttttctt tatcataaca tatttcactg 2782561 tcagcggttt ttcatccatt gtgtgagctg ccgcacgata cgccggtttt cttttggcgg 2782621 gaaataatgt gtgaatgtac tgtagtacca tgtttccacc ggcttatgca gttgttttag 2782681 cttctcttct aataaatagg aatgctgaat cgaaacattt tggtcttttt ctccatggat 2782741 taacagcacg ggagcctgaa ttttgtttac ttggtcaaac ggtgtcctcc attgatattc 2782801 ctcaggcacc tttttcggtg ttccgccgat gactcttttc atcattcgcc gcaaatcctg 2782861 ccgctcctcg tatgtaagaa tcatatcact gacgcctccc caggaaacaa atgaagctgc 2782921 ctgcccgccc atttcgatcg cagtgagcat tcccataatt ccgccgcggg aaaaaccgaa 2782981 gatatggatt ctatccttct tgacatttgg gtgctgctga agcaggcgaa aagcagaaaa 2783041 tgcatcctcc ctgtcttctc cggcaaaatc ctcattgcct tctcctcctt gattgcctct 2783101 gtaaaaagga gcaaacacca caaacccttg ggatgcaaac tggataatcc ggcccggccg 2783161 aaccatgccc acgcttttaa tcccgccgcg caaatataaa aatccgtcat attgtcccgg 2783221 ttccgccggc tcagccagaa gccccttaac ccgtaatcca tttgacagat agcagatcgt 2783281 atacaaacgc acatgctggc ttggcgacgg aaatcttctt ttctctacaa tcaaaacagc 2783341 cgcctccttt tttctatatg ctttccttac tccaaaatta catccggaga acctggttag 2783401 gcattcacac atttttatac ccatcatacg atatgtaaag caaaaaagga tattaacttg 2783461 atgcgaaata aggaggttgt ctatgtgaac agatggttaa ggctgggctt cgcctgtgtc 2783521 ggcagtatct ttctgatgtt cgccctggcg gcttgcaagc aggaagaaac gctcaccaaa 2783581 gtcaaagtag ctgaagtgac ccattcaatt ttttacgcac ctttatatgt tgctgagtct 2783641 aaaggttttt ttaaggaaga agggcttgat gtcgatgtga atacgacctg gggcggagat 2783701 aaaacgatga catcgcttct ttccaacggc tccgacatcg cgcttgtcgg gtcagaaaca 2783761 tctatttatg tcgaagcgca aggggctaaa gatcccgtca ttaatttcgc ccagctgact 2783821 cagacagacg gaacgtttct tgtcgcgaga gaagatgttg aacacttcga ctgggatcag 2783881 ctgaaaggaa aaacgtttct cggtcagcga aaaggcggca tgccgcaaat ggtcggcgag 2783941 tatgtactga acaaacataa gattgacccg cataaggata tagacctcat ccagaacata 2784001 gacttcgcca atattgccaa tgcgtttgct tctggaaccg gtgagtatgt acagctcttt 2784061 gaaccgcagg cttctctctt tgagaaaaaa ggcatcggcc atatcgtggc ttcattcgga 2784121 gaagaatcag gagaggttcc ttatacgact tttatggcga aacaaagcta tttgaagaaa 2784181 aatgaagaca cagccgtcaa gtttacaaaa gccatttata aggcgcagca gtgggttgaa 2784241 aatcattctg cgaaggacat cacagatgcc attaaagatg aatttgatga taccgaccca 2784301 gacgtcatcg aaacatccat tgaacgctat aaaaaacagc attcatattc accagaccct 2784361 ctgcttaacg aaaaagaatg ggagcttctc caaaccatta tggataaatc gggagaactg 2784421 ccgaagcaca ttccatacaa tcagcttgta aataaagaaa ttgctgaaaa agtcacctcg 2784481 gagaaatagg aggcgccatc tatgtctttc ttacatgtcg accatgtaac ccatacttat 2784541 ttttctatta aagaaaaaac aacggctgtg cgggatattc atttcgatgc cgaaaaaggc 2784601 gatttcatct catttctcgg cccaagcggc tgcggaaaaa caacattgct ttccattatt 2784661 gccggtttga ttgagccatc agaaggcaga gttctgattg aaggccgtga gccgaatcaa 2784721 aaagaacata atattggcta tatgcttcag caggattact tatttccctg gaaatctatc 2784781 gaggaaaatg tgcttctcgg tttaaaaatc gccgacacgc tgacagaaga aagcaaagcc 2784841 gctgcactcg gtctattgcc ggagttcggc ctcatagatg tggagaaaaa atatccgaaa 2784901 gaactgtcag gcgggatgcg ccagcgggct gcgcttgcaa gaacacttgc gcctaaccct 2784961 agtctgcttt tgctggatga gccattttcc gcgcttgatt ttcagacaaa gctgtctttg 2785021 gaaaacctgg tattccgcac attaaaggaa tatcaaaaaa cagcagtgct tgtcactcat 2785081 gatatagggg aagcgatagc gatgagcgat acgatctttt tattttcaaa tcagccgggc 2785141 accatccatc agatttttac cattcctaag gaattggccg cgatgttgcc ttttgacgcc 2785201 cgtcaggaac cttccttcca gacactgttt caaacgatat ggaaggagct gaattctctt 2785261 gagaaacagc aaagaaacca ttgatctgct tcacgagcag tatcaattca aacagaaaaa 2785321 ggaaaagtgg aaggtccatt cctttcagct tgccatattt attctctttt tctcgggctg 2785381 ggaaatctcc agcaggcagg gctggatcga tccgctgatc ttcagctctc catcagctgt 2785441 gtggcgatta ttgctggaga aacttggtga cggttcttta ctgtcacaca tcggcgtcac 2785501 tttatttgaa acggtgcttg gctttttgct cgggacgttt atgggcacgt gcctagccgc 2785561 tttgttatgg tggtctaacc gacttgccag aattttagat ccgtatcttg tgattttgaa 2785621 cgcaatgccg aaagtggccc tgggcccgat cctgattgtc gcgctcggtc ccagttttat 2785681 cagcatcatt gcgatgggag ccatcatcag cgtcattatc acaaccatcg ttgtctacac 2785741 cgccttccaa gaggtcgacg aaaactatac gaaagtcatg aaaacattcg gcgcaaaaaa 2785801 gtgggttatt tttaaagaag tcatactgcc tgcatcctcc cccgcgatta tttcaacact 2785861 aaaagtgaac gtcggtttat catgggttgg cgttattgta ggggaattcc tcgtttcgaa 2785921 ggtcggatta ggatatatga ttatttacgg attccaagtc ttcaatttta cactcgtctt 2785981 cttaagcctg ctgatcatcg ccatcttcgc cactctgatg tatcagggcg tcgagctgct 2786041 ggaaaagaaa tggacgaagg ggaggacata aaaaacccgg cacatgtgcc gggtttttta 2786101 ttcaatccat ccagattctt tcagtttttt caagctgatc ggaagaacgg aatccttcat 2786161 aataaagctg aattttttat tgcgggaaag gttctccggc agctcgtgaa acaaaaccgg 2786221 gcctttcgtt tcaaagtaat cagcctgctt ttcaagcttt tctatatctg caaaatatat 2786281 attttttaca atcacttttt cttttccgag aactttatac tgtccgagat acttgaggct 2786341 tttgactctc gcgcccgtct cttcctttac ttcccggagc gcagcctctt ctgcgcactc 2786401 catcggctct actttcccgc ctggaaactc atagcctctg tcctcatgtt ctgttaaaag 2786461 ccatttgccg ccaaaacggc aaatcaccca gacatgcttc gggctgtccg agaaaggctg 2786521 atcgtcaaag gaaagctgaa cagtattctg ataataatct ttaaactcgt acatgtttat 2786581 ccctcaaatc cgttcctagc tatcttccat acatcatacc acagttacgt ttcttcggaa 2786641 gccttttatc aaaaaataag ggaaacccag cacgccgtca ggttctgcat gcagactagc 2786701 tcgtacagtt tttttgcgat acttttgccg gaaagtgcga ccgacgctct gggctttatt 2786761 atgacccgcg aacagggaaa agttacggtt tgcgcttaaa tttatttttt aacgtttcta 2786821 aaagatcgac aagcatctga ggaaccggta tgccaagaga gctggctgtc acaacaattt 2786881 gcacagattc ataaagaata taaaacataa tagccaagtc acgaattgat ccctgtgtat 2786941 tcagcagctg atcaaaaaag tggcatacag agatcagagc cagcgtgact aattttttga 2787001 caagccgggc aaataccttt ttaaatgaca gtttgtgaat aatggtttcc ttcaaagtcg 2787061 tactgataaa ttcaattgcc ataagagaga gcaaaatcag aaatgaatac tgaaaacctc 2787121 caaagaaaaa acccgctgct gaaacgctga ctgctaaaaa cgaaaagatg ccaaagtctc 2787181 tatccattta tcccaacatc ctttcacaga aacggcctta cgatattcta tggtaaacaa 2787241 gccgaacgga ttggattttt cagaaaaatg gactggttgt cgcctatttt tcagatacaa 2787301 aaagaaaagc cggacgtctt ttttaagaca tccggccgtt ctatttttga acttaaccta 2787361 ggtaagcttt tagcatccag ttatgttttt caatattttg atggatcgca agaagcatgt 2787421 cccctgttgt ttcgtcaccg acttcatcag ctaaatccat gccgtttttc agctcttccg 2787481 cgatgactgt gaaatcatca tatacgcttt gaaccatttg ttcagctgtt tcatttccag 2787541 cagcttcttt gacagaagcc gtttctaagg attccttcat tgttgcaatc ggttttccgt 2787601 tcagcgccaa aagacgttct gctaagtcat caatataagt tgctgtttcg ttgtacagct 2787661 cctcaaactt ttcatgaaga gtgaagaaat ctttcccttt cacataccag tgataattat 2787721 gtagtttcac atacatgacc gtccagttgg ctacttgttt gttcactgct tgaatcaatt 2787781 gttctgacat ggtatctcct ccttgttata tgactatgta tacccttaat atcgtacgct 2787841 aaaacctctt ttttaccctt atctgtcacg atttcttcta ttatgctaca attgttaaaa 2787901 aacgggaggt ggaatgtcat gacgcttctc attacgataa gtattttgat tgtgctggct 2787961 gttttgcttg taaccatttg gacgactgta aaagcctata atgtaaagca taccattgat 2788021 ccaccacaag aaaatcactc tgattcacac aatcaatgat gatgtgaatg ctcctcttct 2788081 gactgattgc tggcagcatc ggcgtctccg acttggactt ttaaggtcgg catgctatgc 2788141 tgtttttttg ctgtgacatg agattggaca gtgtatacac catcttcctt aaacgtcgtt 2788201 tccaatcggt atacgccttt ttcttgtttc accttaaaca tttggcttgc gtctttttcc 2788261 ccttctttcc atacttcaaa ctctacttca tcggcatccg tcacagcttc atcaccatat 2788321 gatacagctg cttcataagc agcgctttct ccgggattta ctttttcagg cccggtcagc 2788381 ttgacatcca aaacctcggg cgtctcagct gtatttgctt tactttcacc agatccgcat 2788441 ccattaagca ataaagcaga aaaaagcaga acaaccaaca tctttttcat gccatcaccc 2788501 tttcatcgtt tacctaaata gtagcaaacg cttacagcaa atggtacaca aaatatgaga 2788561 cgtcacaaaa aagacctttt tgcttaagcg caaaaaggtc ctttctattt tagccaaata 2788621 cttttagcaa ttcttcttta tcctgtgaaa gccagaaacg cattaaacgt ttagcgcctt 2788681 ccagatcatg aagcttcgct tggccgcact gcttttcatt cgcagcaggt atttctgtaa 2788741 tctctaccgc ttccttcatt gtgtcttcaa gcagatcaac gatttccgct gatgtcggct 2788801 ctccgctcac aactagataa tagcctgtct ggcagcccat tggagaaata tcaatgatat 2788861 caaaatgatc gtatttctca gcgtgagaac gaatcgtaaa cgcgagcaaa tgctcgagtg 2788921 tgtgaatggt gtcaggcttc atcgcctgtt tatttggctg gcaaaaacga atgtcaaatt 2788981 tatttacaac gccgtctgtt cccactttat gcacgccgca atgtcttaca tatggagcaa 2789041 caaccgcatt atgatcaagc tcaaaacttt ctactgaagg cataatggca ctctcccctt 2789101 ttttaaaaat gtaatttcat tataacatac ttttccgata agaattattg attaactttt 2789161 caatctgtgt tttttttctt atacttgcat cagaaaggtt gctgaagaaa catgaaaacc 2789221 ctattcatcg ctctgatcag aggatatcaa aaattcatct cgcccctgac accgccaacg 2789281 tgccgctttt atccgacctg ttcccaatat ggaatcgaag cgattaaaac acatggcgct 2789341 ttaaaaggcg gatggctgac aatcaaacgg attttgaaat gccacccgtt ccatccggga 2789401 ggagtcgatc ccgttcctga aaagaaacaa aaacattaat tgttataacc gtttacgata 2789461 agatccagtt ttccggtttt aggatcaatg actaagccat ggaccggaac gttttcaggg 2789521 aacagcgggt gatgtttaat aacatctacg ctgtctttca cactcgcttc cactgaatca 2789581 aagcttttaa accattgatc aaagtctaca ccggagtact ttattgtttc gatgcgttct 2789641 tccggaatcc ctcttgcttt gattttttca agcatgcttt tgctgctgat tttgctcatg 2789701 ccgcaatcgt gatgcccgat cacacacacc tcatctgcat tcagctcgta cactgcgacg 2789761 agtatacttc tcatgatgct tccgaatggg tgtgtcacaa gcgcaccggc acttttaatg 2789821 attttcacat caccgtttcg caaattcatc gcatgcggca gcagttcaac cagacgagta 2789881 tccatgcaag aaagaatcgc cattttttta tctggaaatt ttgatgtttg atacttttca 2789941 tactctcttt gttcagtaaa tgtcttgtta aattcgagaa tatcatttag aagactcatg 2790001 ttcgttgtcc ctttctattc tttttactct tcaatatatc acaacccttg tttattcgtc 2790061 ataataaaaa aagacaaacc ctcaggcctg ccttatttcc ccatgttata gcgttttttg 2790121 aactgctcaa ctcgtccgcc tttttcattg aatttctggc ggcctgtata aaacggatgc 2790181 gtgtcagagc ttacctctac tttaatgaca ggatatgtgt ttccgtcctc ccactctgct 2790241 gtttcattag atgttttcgt agaggtgctt agaaaacggt agccgctgtt gacatcctga 2790301 aatatcactt tgtggttctt tggatgaatt ccttctttca tgggtatctc ctttcaataa 2790361 atcgtaataa ttacgtttta ttttataacc ttacaaacgt tttgtcaatc ttcttatatc 2790421 cttccctctg tttcacatcg taaacctcat ggcatttaag aataggaaga ataatctaac 2790481 cgaggaagca aataataaac ccaaaataca tacagaacgt ctttttggaa aggtggttta 2790541 cgattgtgga tgatttagtt ttggccagaa gcctttttgg cacgacgatg ggctttcata 2790601 tcattttcgc aacacttgga gtcggtctgc cgctcatgat tttagtggcg gaattgatct 2790661 atcaaaaaac gaaagatgac cattatgcga tcatggcgaa aagatggacg aaagcacaag 2790721 ccgttttgct gggggtcgcc ataccgaccg gaacgatcgc gggcactcag ctcgcgcttt 2790781 tatggccggg atttatggaa gtcatcggcc gggtgatgtc cctgccattt caaattgaaa 2790841 tctatgcttt ttttgttgaa gccctattca tgtcgattta tgtatacgct gcagaccgtt 2790901 tgtcacctgc aatgaggatt gttgctgttt tctttgtgtt agtcggggca gcagcatccg 2790961 ctgttctgat cacgaatgtt cacgcttttg aaggtacgcc cgccggtttt aaaattttaa 2791021 acggaaaaat tacagatgtt gacccgtggg ctgcgttttt taatcctagc ttttttatca 2791081 ctgccggcca tgtcgtgctg tccgcgttta tgactggtgc gtttatcgtg gcttctgttg 2791141 cggcgtataa aatgatccga acgaggaaaa aggaaagggt ctatcgcttt caccggaaag 2791201 cccttttgct cgcactgacg atcggcggta ttttttcatt gctgaccgct ttgaacggac 2791261 acgaatctgc acagatgctg tacgaatacc agcccgaaaa attagccggt gcggaaggcc 2791321 tatttgaaac aagatcccac gccccgctcg ctatcggcgg ttttaccgac ccgaatgaag 2791381 aaaaagtaaa atgggcaatc gagattccat gggctttaag ctttttggca gcgaaccgtt 2791441 ttgacactgt tgtaaaagga ttaaatgcat ttccgagaga tgaatggccg ccgcttttca 2791501 ttcacacgct gtttaatgcg atggttggtg taggcatgct gctaattctt tattccatta 2791561 tcggtgtggt ctggagaaag gtgctcaaga aagaccgttt cccaacgtgg cttttgatca 2791621 ttttcatgac agcaggccct tttagtctca tcggcattga attcggctgg attttcgcat 2791681 gtacggggag gcagccttgg gtcatctatc atctgctgaa aacgtcagat gtcgtaacaa 2791741 cgactggctc gatcggggtg ctgttcttat ttttcacatt tgtttatgcc gtgttaggcg 2791801 cagctgtcgt ctacgtgctg ctgtattatt tccgcaagca cccggttgac gaagatttaa 2791861 atacagcgga gtcgtaatgg ctccgcaaac aggaaaccaa atggaaggaa gatcgtacaa 2791921 atggagattt caactgacgc tctgatcgcc atctcaatta tctggggctt tgtgtttatt 2791981 tacgccgtca tggcgacaat ggattttgga gcgggatttt ggtctatgat ctatttaaac 2792041 aaggagcata tgaaggccac cgatattgcg aatcgctttt tgtccccgac ttgggaggtc 2792101 acaaacgtct ttattgtggc catcgtcgtg gcgcttttca gttttttccc cggcgcgaca 2792161 tttgtgctcg gcaccgtttt attaattccc ggaagcatga ttttgctgct tttagcaatt 2792221 cgaagcggat ttctcgtgtt ttcaaataca gcaaaggagc ggaaaacgct aagatatatt 2792281 tccggcatct ccggctttat cattcctgct attttaattt tggtgcttcc tgtgacacac 2792341 ggagggttta tagaaaaaac ggatggaatc tataacttaa atatgtctaa aatcttttca 2792401 agccccaacg cctattcatt tatcgggttt gcgattttaa gcaccttatt tttgtcctcg 2792461 ctgttgcttg cagatttttc aaatgtggca gaggaacagg atgcgtaccg agcctacaga 2792521 aaaagcgccc tgattaccgg cccgatttca ctgttgtttg ctgtatgcat tatggtaact 2792581 atgcggaatg aagcaaactg gctgtacagc ggaatgatga atgatttttc ttggattatt 2792641 gcatcgttca ttacatttgt cattgctgga atcgctcttt ttctgcctaa caaaagcttt 2792701 ggtcaaaaca tcggaaaacc gcgtctcgca cttgttgcga ttgggataca gtattttctc 2792761 gcaagctacg cgtacgggcg ggcgcatctt ccgtatatga tttatcccga tgtgacagtc 2792821 atgtcaggct tcacagagcc agcaacgttc agagcgctgt ttgcaacgta tatcgttgca 2792881 tttatcattc tatttccggg cttctttttc ttctggaaaa tgtttatgcg agataaacgc 2792941 tatatccgcc aggaggaata gagggcaagc cagccggcta tactaatcca gaacctttat 2793001 aaggagggga tggcatggag cagaaaattc tatgtgaggt caacaactgt tcttattggg 2793061 gcaaaggtaa caaatgcacc gctgatgcca tttatgttgt cagccatact ggtgaaacgg 2793121 ctgaaaacag ccgggaaaca gactgcaaaa cgtttaagcc gcatgattta taattaaaag 2793181 aaagagctgc atcagccagc tctttctttt tgcatgttga gtgttctcag ctttttagtt 2793241 atgaccccgt ttgcaggtga aaacaaaaag gcgcttgcat aacatacacc tgtcatggcc 2793301 gccatcgctc ctgaaatcga aacattaagc cacgttgcga agaaatagcc catgaccgcc 2793361 gacagcccgc caatcaacgc gctgagaatc agcatataaa gaagccggtc tgtcagcaaa 2793421 tgtgccgcag ccggcggaac aatcagcatg gccacaacca atacggcacc caccgaatca 2793481 aaggaagcaa cagtcgtcaa ggacagcatg cccatttgca cgtaatgaat gagcaaaacc 2793541 ggtattccca aggctaaagc catttgagga tcaaacgaag cgattttaaa ctccttatag 2793601 cacacactga tcaacactac gtttaaaacc agaacagatg ccagcatcca aaacgctttc 2793661 ggcccaatat caaccccgaa taccgtcacc gtattccacg gcacaaaagc gatttctccc 2793721 attaacgagt gctcaatatc gagatggaca ttcgctccat acacagaaag caaaataacc 2793781 ccgattgcaa ataaggatgt aaacacaact cctatggcag catctgattg aacccccttg 2793841 ctatgaagaa gctgaaccaa gaaagccgtt aacagaccgg ttgcggctgc gccaataaac 2793901 atataaatcc catcgagact tcccgtcact agaaaagcgc cgacaatgcc aagcaacact 2793961 gtgtgactga ttgcgtcggc cagcatcgcc atgcttctca gcacaagaaa tgtgccgatc 2794021 aatccgcagc ttacaccgac taatacaccg gtagctataa tccatgcttc aaaactcatt 2794081 tgcgatctgt cccttctcgg catcatgaga cgcttttcga cgctcaggca tccgtccata 2794141 cagctttaag agtgaataaa gccgctctct cgtttctctc ggtaaacggt ccgggtcaaa 2794201 gtagtcctga tcggattcta tattggcaag ttccatttca tgcatgagat acacttcata 2794261 catccgctgc ttcaaagctg tgtgatagcc tttttctatc cctttgcttg tgatttgcca 2794321 aatcccattt tcgatacgct caatgcacct ctcttgttcc aagtcattta atgccttaag 2794381 gcataatgaa ggggataggc gtcttttctt tcttacactt tcaacagtta cacaaagatt 2794441 attcttttca tactgttcat aaatcgccaa aagcacttgc tccctgcttg ttctgcgccg 2794501 cagcctcatc agccttatgg ctttagcagc caatccccgc ttaggcgcgc aaatcattga 2794561 aaaaagaaag agcagcgttg cagataagat cattaatggc cctgtcgcca ttcccttcat 2794621 cgtggtgcta agcagggttc cggccactcc gctgaccccg cctgtaatcc cggcaatgat 2794681 gatcatcccg gttaatcgtt cggtccaata tctcgcggtt atggcaggtg taatcagcat 2794741 agccgccatt aatatcacac caacagtctg aagcccaatg acgacagcac agacaatcag 2794801 acaagccaaa agcccgttta aaaaacgcac cgggattcct aatccctttg caaacgcgag 2794861 atcaaaagta atcaatgtaa attccttaaa gaaaacaata cataggagca gtagaacagc 2794921 ggatatccct gcaataagga tgatatcctg cctgaccaat gaagcagcct ggccgaataa 2794981 aaaagaatca agcccgcttt ggcttcccgc cccctgttgc tgaatatatg tcagcagaat 2795041 gatcccgacg ccaaaaaaca cagaaagaac aatcccgatc gccgagtcct cctttgtttt 2795101 tgaaagccga ggaatcagct gaatacaaaa cgttccgagc agtccggcga gcgctgcccc 2795161 cagcaaaaag aaaggcagtg atttttgccc ggtgaacaga aaagcgagac acactcccgg 2795221 cagagctgaa tgggccatcg catcgccgat taaactttgc tttctcagca gcacaaagct 2795281 gcccaaaaca ccgcttgccg tcccgagcaa aagcgtaccg gccagcaccc actgtgtatt 2795341 cggatgctga agctgcagcc acaaactttc aaacattgcg ctcactcctt atgtccttct 2795401 gccagcactt tatcttttaa aaacgtaagc cttcctccat atgttttttg caggttttcg 2795461 atcgtaaaaa cgttttccgt cggtccgaaa gcgattttcc ttaaatgaag cagtaagatc 2795521 caatcgaaat aatcctcggc ggtctgcaga tcatgatgga cgacaagcac ggtttttcct 2795581 ttttctttga gttctgccaa cagcgtcata atcgcgcgct ccgtcgctgc atcaacacct 2795641 gcaaacggtt catccataaa ataaatgtca gcgttctggc agagtgcccg ggcaagaaac 2795701 acccgctgct gctgtccgcc tgacagctgg ctgatttgcc ttttcgcata atcatgcatc 2795761 ccgacttttg ttaatgcggc cttcgccatc tccacatccg ctttctttgg cctctttaat 2795821 aaaccgattc tcccgtatct tcccattagg acgacatcga gcgggcttgt ggggaaatcc 2795881 cagtcaaccg agccgcgctg cggaacatat ccgattctgg tccgctgatc cttatagtct 2795941 ttgccgtaaa tagagatgtc tccggaagct ctgggcacaa gaccgagaat cgttttgatc 2796001 aaggttgatt ttcccgcgcc gtttgggccg ataatgccaa taagttttcc ttcaggcacc 2796061 tgcagcgaaa tgtcctgcag tacaggcttt ttatgataag caaccgtcac attatcaagc 2796121 tcaacaggga acatatcctc cacctctttt ctttatttaa gcgctttagt aatcgtgttg 2796181 atattgtggc ggaacattcc ttcgtatgtg ccttcttttg tgcccttttc acccatggca 2796241 tccgaataaa gctgaccgcc gattgtgact gtatggcctt tttctttagc gccttccacc 2796301 actgcattga ttgatttttc agatacactg ctttctacga acacagcttt tatttgtttt 2796361 tctgtcagaa gatcaaccag ctcctgaaca tcccttaatc catagtccga atctgtgctg 2796421 agtccctgca ggccttttac cttaaatcca tactcattcc caaagtacgc aaacgcatca 2796481 tgagcagtca caagcacacg gcttttctcc ggaatatgtg cgatctcctt acgcgaccac 2796541 ttatctaaat attgcaaatc ttctttgtac tctttggcat ttttccgaaa ggcatctgcg 2796601 tgctgaggca ttgctttgct gaattgcgct tcaatttcat ccaccgcata gatccataac 2796661 ggaatgctga accagacgtg gggatcaaac gtcttgcctt cccccgcggg aataagctta 2796721 tttttcggaa tggcctcagc tactgccgcc gattgttttt gttcgccgat tttttggagg 2796781 acatcctcca ttttcccttc caaatgcaac ccgctgtaca gaacaacatc ggcagacatt 2796841 aattttttcg tgtcaccttg ggaagctttg taaaggtgcg gatcaacccc cggtcccatt 2796901 aaagaggtga cttttacgtg cttacctccg atgttttctg ctgcatcggc aatttgagat 2796961 gttgtcgctg tcacttgtaa ttgctgatca gcgctttttc cggctgaatc cgttccgcat 2797021 cccgttaaag caaaggtcgc aaaaagtact gctgccatca gcccttgtct catatttctc 2797081 ctcctctttg ccatcaatgt ccgattgttt tatcttatgt tgtcagttct tagacatgtg 2797141 acattaaatt agccaaaagc atgttttatt tacacaggac aaaaagtttc cctcatgcaa 2797201 aattatcgcg tttggccatt tttgtcaagc tgatttacat aaaaaaaccg gctgggtcag 2797261 cagccggtcc aaacgagaag ggatgtattc aacgaacact tttactgtaa cagcacagtg 2797321 tcatttattc aaaatagcaa aatgcttttt tcttaaccat gctgtgtgaa aacatccatt 2797381 ttggtcacat attttcgcat aatatcttgg tttacctcaa cccctaaacc aggctgtttt 2797441 gacacagaaa taaatccatt atcaatacga atatcaggag ttacaatatc ttcatcccaa 2797501 tagcgtgagg atgaagatat atcgccaggt attgtgaatt gaggcagtga agcaagcgcc 2797561 acgttctgcg ctcttgatat gcctgtttcc agcattcctc cgcaccaaac ctgcatatga 2797621 tgctctttgc ataaatcatg aatttttaag gcttctgtta agccgccgac acgagaaggt 2797681 tttatattaa taattttgca gcttcctagc tcaatcgccc gtctcgcatc atcaactgaa 2797741 caaatgctct catcaaggca aatggccgtt ttcaaatgtt tctgcaagtg gcggtggtca 2797801 acgatatcgt cagcttggag cggctgctca atcatcatta aatgatagtc atcaagctcc 2797861 tttaaacggc tgatatcctt cagttcgtaa gaggaattgg catcggccat aagcgggatg 2797921 gttgggaatc ggctgcggat ggccttgacc aattccacat cctgcccagg ctgaatttta 2797981 atttttattc tttgataacc ttctttttga tagctctcaa tttccttcag catatcgtca 2798041 agaggcgcca ggccgactac caccccggca gggactttat ctcttgttcc gcccaatgcc 2798101 tcagcaaggg atacgccctt ctttttggca taaatatccc atacagccga ttcaagtccc 2798161 gcttttgcca tccggtttcc tttataccgc gccaggctgt ccggcacttc tgaagggtga 2798221 ttgaattcac ggccgacgac atttgggata aaaaaatctt ttagcatatg caaacatgtt 2798281 ccaatggttt cctcggtgta ccaaggcgaa gagaaagcgg aaacttctcc ccagcctgtg 2798341 acacctgatg tatcaatggc ttccacgatc agaaatttac gctcttgaag cgtttcgata 2798401 ctgtttttaa acggtttctt taagttcatg ctcaaatggt aaagcgtgat tttttctatt 2798461 tcgatcatag cagttctcct ttacgcgcat ccttcagctg atttcgcaag agcttattag 2798521 acgcattgcg cggcaggcgg tcaagcacaa agaattttgc cggaatttta tacttcgcca 2798581 agcgttcttt gcagtagtca gtcaattctc ctgcgctcac aggcttgtga aggacaagat 2798641 aggcgtgagg cactttcccc cattttttgt cctcagcccc tgaaaccccg gcttcggcca 2798701 cagcggggtg tgaaagcagc actgactcca cttcggccgg ataaatgttt tctccgccgg 2798761 atatgatcag atctgaacgt ctgtctaata catataaaaa gccttcattg tccaaataac 2798821 caagatcacc tgttttcagc cagccatttt gaaaggaggc ttcgtttgcg ctctcccggt 2798881 taaaatagct tttcatgaca ttcgggcctt tgaccatgat ttcaccgtgt tcatacggtt 2798941 cacatacctg tccgtcccgc tctattttga tttcacacga aaacagcggt ttccccgcag 2799001 atccgagctt ttccatgctg aattccggcg acagggtaac aatttgcgag catgtttctg 2799061 tcattccata tgactgaaag acagggaatc ctttctcacg gcattcctca agcaatggca 2799121 gcggtgcagg accgccgccg agaagaatgc atctgatgga ttcagggcag cggtttgttt 2799181 cttccaaaag actggccagc atagtctgca ccgcagatat cattgtcact tcatgcctgt 2799241 tgatagaatg cagcacatcg cttacggaaa aacgctggtg aagcacgaca gtcattccat 2799301 agatcacaga tttaaataat gcggacaatc cgctgatatg aaagagcggc aatgcgataa 2799361 gccagcggtc ttgttctgtt atacccaaat taagagcgga cgacaccgca ctgaaataat 2799421 ggtttccgaa cgtttgctga actcccttgg gctttcctgt cgtacccgac gtatacatca 2799481 gcgttgccgt tgcatccatt tgcatataag cctcgatctc aatttcctct gctgcttctt 2799541 tcatcagttc atccacatca atcgtttgaa cgatgtgttc atattctttc ttctcaaagc 2799601 ttgaatctgt caataaaaag ccggatcccg aatcctccag ctgaaacagc ctttcatgtg 2799661 ttgacagctt cgtattcaaa agcaccgcct taacaccaag caaaaaacaa gcgtgaacag 2799721 cgtataccat ttctgcacgg ttttggagca aaatagctgc agtatcccct ttccgaaccg 2799781 aatgagcggc aagctgttcc gccattcgtt tagacgcggc aaacaattct gcaaatgtca 2799841 cggtttggtc ttcatagatg agagcgattc tctcaggtgt cagctgtgcc cgctgcatga 2799901 gccagttggg ctgttctgtc agcatgtcat catctccgag gtaaaatgtc tgtattgaaa 2799961 agaaaacagc ttggaccgca aagtctcaag ctgttggttt actagatatt gctgatcacg 2800021 gaaaacgagg gaactgtccg aaatcaggtt tgcgtttttc cttaaaggaa tcacggcctt 2800081 cttttgcttc atctgttgtg tagtaaagaa gggtagcatc ccctgcaaac tgctgaattc 2800141 cagcaagtcc gtctgtgtcc gcgttaaacg cagctttaag aaagcgcagt gcggtcgggc 2800201 ttttttcaag catttcttca caccatttaa tcgtttcttc ttcaagctgt tccaaaggaa 2800261 cgactgtgtt gacaagaccc atgtccagtg cttcctgtgc gttgtactga cggcataggt 2800321 accagatttc acgtgctttt ttatgtccta caattcgagc caggtagcca gaaccgtaac 2800381 ctgcatcgaa gcttcccact ttagggcctg tttgtccaaa aattgcgttg tccgcagcaa 2800441 ttgtcaagtc acatacgatg tgaagcacat ggcctccgcc gatcgcatat ccggacacca 2800501 tcgcaacaac cggtttcggg atgacgcgga ttaaacgctg aagatccaat acgttaagac 2800561 gagggatctg gtcgtctcct acatatccac cgtggccgcg cactttttgg tctccgccag 2800621 aacaaaatgc tttgtcccct gcaccggcaa gcacgataac cccaacgttt tggtcgtctc 2800681 ttgcgtcagc aaacgcatca atcatttcag caaccgtttt aggggtaaac gcattatgta 2800741 cctcaggtcg gttgattgtt atttttgcaa tgccattata cgtttcatac aatatctcat 2800801 cgtatgtccg ttttgttttc cattcagcca tatgatgacc tccttttatt ctctatgtga 2800861 atgagtcaga tgcttgtcaa aaactcactc actattttac caaacaatcg cggctgctcc 2800921 acatggaccg tatgtcctgc ttttggaaca atctctattc tactagaagg aagcatctta 2800981 tgcacctctt gattgatggc gcaaaatttt tcgtcccact ccccgcagat cagaagcaca 2801041 ggaacatcta tttcctctac acggctccac aaggaaggct gtgaaccggt gcccatgccg 2801101 gttaaactgt tcgcaagccc aatcttattg ttccgcagac ggcccgatcg tatcctgtac 2801161 cgaatatctt cagccagcct ctgctgagat gaaaacaaag ggatattctc ccaatacgca 2801221 acaaacgctt cgagcccgtc tcgtaaaata aaatcagcaa gcttccggtc ccgcatgatt 2801281 cgttcccgcc gttccccaag tgttttgagc cccggcgtcg tgctttcaag cacaagtgcc 2801341 gatacccgct cgggatatgt catcgcaaaa gagtaagcaa gccttcctcc catagaatac 2801401 ccaatcaatt tcactttgtg aagttttaat tgatcaaaaa tctcggcaag gtcagaaact 2801461 tgccgggttg tgctgtatct tttcccattc agcggggcat cggtttcccc atgccctaaa 2801521 caatcaattt tgatcaaacg ggaatcaggc agcatttcat caagaaaagt ccatgattgt 2801581 ttgctgccgg taaacccatg cagacagacg acggcttcgg aagcattcgg tccctcgtct 2801641 gccactgcat atcggacacc atctgatacc gttatgttta cagttcccat tgttttttca 2801701 cttcccgcac agcctcattc agcatatcgc gatgaagctg gactcttgat tggcgatccg 2801761 ttttgatttc aatcaaatgg agtccgggct tgtctgcctg cggcgcgtaa gctgttttga 2801821 attcatccca agaagccggg catgaatacg ttccgccgta aagtgcagcc gcatgcttga 2801881 aatcgagccc tgtcggtgtg ccgaacaaat cttcaaagtg tgtcttctca gaagcctgcg 2801941 gcaaaaagga gaaaatccct cctccgtcat tattgacaag aatcacagta agaggaatac 2802001 ccagcttttt ggccgccagc aggccgttta aatcatgata aaaagataaa tctccaatca 2802061 caagggtaac aggcgctttt gttccttcac atacccccat ggcagaggag acgacaccgt 2802121 ctatcccgtt tgctccccgg tttgaataaa tccggaaagg gcggtcctgc ttttcaaaaa 2802181 acgtatcaac atccctgatc ggcatgctgt ttcccacaaa cagcgagctg ttttcaggca 2802241 caagatgctg aaggattcga tagagattgc cttcaaacga aacatcttca ctgctgattg 2802301 tttgcagatg ctcgcggaac cgcccattga caaactgcca cttttccagc cactctgagg 2802361 atctggtggc agcagtaagg cctgccatga tctcctcagc aaaaacagac gcattacaat 2802421 gaatcatatg cgcgcttgcc tgtgtcgggt ctctccaccc tccatcctcg tcaatcacga 2802481 tttgctgaat cgtcggatca tccttaagcc ataagaaaac cggttttgaa acaggcatcg 2802541 gtccaaaccg aatgacaaca tcaggacgga gtttccgctt cagctcatca tcttttaaaa 2802601 acgaatcata cgcatcaata acagtgcttt tatcatgaac accattccgc agattagaca 2802661 gcggatctgc taaaattgga tactgaagcg cttttgacag cgcaataatg ttttccttgt 2802721 ccgcatcact atggagctct ccgcagacga tcattccttt ttcagcctct gcgagcatct 2802781 cagccacatc agacagggac tctcggtcaa cagactgcgt acccgttttc acagacacat 2802841 gacggcctgt tctcattctt ccaaacggct catctgaaag atccggcatc agcggttcgc 2802901 gcagcggcac attcacatgg acaggcccca tcgggcgctt ttgtgcttct ccggcagcgc 2802961 ggcttgccag cgttcggatg tatctcagca tttgcggaga ctcttcagga agagcagagt 2803021 ctgtgaaaaa cttaacaaag ttaccgaata agaagtgctg attaatagcc tgcggtgcgc 2803081 ctacttcgcg cagctcatga ggccgatcag cagttaacac aataataggc acccttgaat 2803141 aatgggcttc aaccacagcc ggataaaagt tggccgcggc tgttccagat gtacagatca 2803201 atagtacggg acgctgcttc gcttttgcca aacctaatgc aaaaaatccg gcagaccttt 2803261 catcaatttg gacatggacg ctgatatcgg gatgcgcagc acaaagaaca gccagcggtg 2803321 tagatcttga gcccggacaa acgacggcgt ccgtaattcc ggaaagggcg aattcatcaa 2803381 taaaacttcc gatgtaatga gtaatcgggt tgactgtcaa cgcctctcac ctcctaatgc 2803441 agagatcatc ggcttcaatt taatctgtgt ttcttcatat tccgagattg gttccgagtc 2803501 ttccacaata ccgcacccgg caaacagcct tgctgtgctt ccttcgatga gccctgaacg 2803561 aatggcgacc gcgaattccc cgttatcctg gctgtcaatc cagccgatag gggccgcata 2803621 ccagccgcgg gacatcggtt caatctccct gatcacgtca acagcttttt cctgaggtga 2803681 tcccccaagc gcgggagtgg ggtgcagctt ctcaattaag tcaaaaatcg aagcagactc 2803741 gcgcagctgt ccgacaatcg gcgtaaacag gtgctgaacg ctttttgttt tgtacaaaac 2803801 aggtccatca ggcttttcaa cctctgaaca gcttgataca aaagcattat gaatcatacc 2803861 taccacaata tcatgctcaa gcaggttttt ctcatcgttt aataattcaa ggcctatccg 2803921 gcggtcgtct tcttcattca cgcctcgttt aatggagcct gccagacagg aagacatgac 2803981 agtgccgccg tctcttttga tcagtctttc cggagacgcg ccgacaaagg ttttgccttc 2804041 ttgttcaatt gcaaaaacat agcttgtctg ctgatcgtcc agaagcgttt taagcaccgg 2804101 ttcaatttgg attggaccgt caaacgtgag cagcagctct cgggcaagaa caaccttatc 2804161 atattgtttc tctttaattt ggcttgtggc cgtttcgatt gctttcagcc aatcatcctt 2804221 atccagctct tcggctgctg caatcacagc ctgatcttct tgcttgaaat cgggaaccat 2804281 aaattccgcc gcaaaagctt ttaagccttc taaaacagct tctgcgtctt ctcctccgct 2804341 tacccatctg ttaactgtta agaacgggcc ttcagcagtc atcgtcagca taagcgcagg 2804401 cacaaagaaa tccccttccg agaaatggtc ccattgtgaa cctctttctt cgcaagggtc 2804461 aaaagaaaat cctccgaata acacaggtcc cactgcagaa tgctgcagct tttcttcttc 2804521 ataaatatga aaagccgtct ttttaaagcg ctcccattgt tcaaaaacct cacgataccg 2804581 ctcgctgttt ttttgatttg tctggaaaac cgcttctttg ccaagaccga ctattgtcaa 2804641 ttcactttca ggatctgacc aaaaaaatcg attgcctgta tatttttttg ctccgtaatt 2804701 gaaaaatgat agagggtcaa gagactcgat ttgtctcgaa tagcttatta agacagcatg 2804761 gttgacttct ttggctttat gtaatgcatg tagaacttcc tttcggaacg tacgctgcac 2804821 cgttgtcacc atgagacatt cctccataat ccttaaaatg cttttaatac catacacctg 2804881 tgtctccttt gtgtcaaaca cagatcatgc agtccaaatg gcctgcctta cctattataa 2804941 acctaatttc agaaatgaaa aagaaacaaa gcttaaattt ctttctccac tgatagcaaa 2805001 ggttgtatcc gcttaccata aaaggaaaac ctcctatatt cctccacccg ccatttatga 2805061 aagttctcag gcgatctgtt catactaaag gtatgcatca cagagaaacg aggcgatcac 2805121 attgcttacg aaagaacagc ttcagcattt aaaaaatgaa ctggaacaaa cgaaaaaaga 2805181 tatcttaaac cgtttcaaag acaatgatca ttttcagctt aactcagcct ttccttatga 2805241 ttcgtggggt gagctttcgg catacgacaa ccatcccggc gatcaggcga cagaacttta 2805301 cgagcgtgag aaagacatcg ctctagactt gcatgagaga gagcaccttc gggacattga 2805361 gcattcattg aaggcgatag aaaacggtac gtatggcatt tgtgaagtca gcggaaagga 2805421 aatccctttc gaacgacttg aagcgcttcc gactgccaca accctcgcgg agtattcgtc 2805481 acaggacgtg gtttccaaag accgtccgat tgaagaagaa acaccattcg ggcaatttga 2805541 atttgatgat gatgaagaaa tcagagcgcc atatgacagt gaggattcct atcaggatgt 2805601 cgaaaaatat gggaactcac aaacgccgca ggatatggaa aaccctccgc tcagctatga 2805661 tgatatgacg atgaatgccg aagagaatat cggcaatacg gagtcttacg aaaatttcat 2805721 cgctacagat atcactggga aagaaattac cgtttatcaa agcagagccc atgagcgcta 2805781 tgaagaagaa cttgacgaag agggaatcat gaccacattc ggcgatctcc acgctgattg 2805841 aacccccaat tattgggggt tcttttccgt tttcagcata tcgtaaatca gcttcagata 2805901 atccttttgc aggccgatgt cataccgctc gccctctagc aatttcccgt atacggtaca 2805961 tgccccgagc gaagctttta tcgcatccgt tacctgcact tctcctccgc tatcagcttc 2806021 taatgcctcc agctcattaa aaatatccgg tgtgaaaata taacgccctg ctgcggcaaa 2806081 atgagacgga gggttttgtt taggcttttc cacaatatcc tgtatgcgat aaagcccttt 2806141 ttcaacaggc tcccctttta tcaccccgta atgatgtaaa tcctccgttt ttgtttcttt 2806201 taagccgatc acactggact gatatttcgt atacgcttca atcagctgcc ccaaagccgg 2806261 ctgattggcg gaaaaaatca gatcatctgg caaaacgacg gcaaaaggct ctcctcctgc 2806321 aaattgcttt ccgaaagaaa tggcgtcgcc aagacccttt gcataaggct gccgcacata 2806381 gtgaatccgt atatccggaa tgggatgctc tctaagtaaa tgcagtttat tcttagaggc 2806441 caaaaaagcc tcaagtgcca aagaggaatc aaaatagtcg acaatcagat ttttatggct 2806501 cgatacaacc atcaaaatgt cctcaatgcc tgactccttt aattcttcaa caagataatg 2806561 aatcacaggc ttagatccta ccggaaacat ttctttcgga atcaccttcg tcaccggcag 2806621 atttctcgtg ccgaatccgc ctgcaggaat gatcgctttt tttatcatgg tattttcccc 2806681 tcagctcatg tttattacat gatattccaa gagcgcatcc cgatgtttgt acatctgaaa 2806741 ttaggcggaa gcaactgggc agaaagcgga atcacgaacc agcccttttt taataggata 2806801 ttgatatatg accagtaatc ttgtaaagga gctcaggtga tgaaaatttg tgtggttggc 2806861 gccgggtatg tcggtttaac cctatcagcg gcactggcat ccatcggaca tgacatgata 2806921 tgcacagaca aagacgtcaa aaaaatcggg cagctgaaaa aaggagtcat tcccttttac 2806981 gagcctgggc tttcagatgc aatacttcgt tgcggcaatc tctcgttttc ttctgaagtg 2807041 aaatcgagca tggaggaatg tcccgttatt tttatcgcag tcggaactcc gccgcgttcg 2807101 gacggatcag ctgatacgaa agccctgcag tccgtcatcg gtgatttaag cgaggcgatc 2807161 cgatcgtata aaaccattat tacgaaaagc actgttccgc ccgggacaaa tgaaaacata 2807221 gcaaaacagc tgattgcctc cggagtgtct aaaaacctct ttaatatcgt atccaatccg 2807281 gagtttctgc gggaaggcaa tgccttatat gacatgctgc atcctgacaa aacagtcatc 2807341 ggtgttcagg aagaagatca cgtatcggca gccatcgtca aatccattta caaacacatt 2807401 gatacccctt ttatcgttac aagcttagcg ggagcagagc tgatcaaata tgccaacaat 2807461 ttctttttag cggccaaaat ttcgttcatt aacgaaatgg cccgcatatg tgaagcctat 2807521 caatcagata tctcagatat ttcccgcgct atcggtctag acccaaggat cgggaagcac 2807581 tttttgcagg caggcatcgg atacggaggc tcttgttttc caaaggatct gcaggcgctg 2807641 caatttgctg cccaggaaaa aaacacggag accttcctgc tccgggccgt gcagcacatt 2807701 aatgacaccc agcttggcct gtatatcaaa aaaatacagt cattcttcga aacacttcaa 2807761 ggcaagaaag cggctgtact cggcatttcc ttcaaaccga atactgatga catccggaat 2807821 tctcaggctg tcagactgat ggaaaggctg gcggagctgg gatgtgatgt tcatgcatat 2807881 gatcctgaag ctgtacttcc agaacatttg cggcaacatg taactcagca ttctcaagct 2807941 tttgatgcga tcgaagagag tgacttttta tttttggcga cagaatggtc tgagttttta 2808001 gcgtttgatt ggaaaaaggc tgcagatatc atgaaagggc gtcttgtgat tgacggacgc 2808061 aacgtactaa aaaaagaact gatcgaggct tgcggcctga tctgtacggg agttggccgt 2808121 ccatgaaaat actcgtcaca ggagcagcgg gctttatcgg ctcccacctc tgcgaagaat 2808181 tactaaaaga taagaaacat aacgttatcg gaatcgatga ctttatcggt cctactccat 2808241 tttccttgaa attaaaaaac cttaaaaacc tgctgccgga aaagcgattt acgttcataa 2808301 aggaaaatct gctgacagcc gatcttgctt ccttactgga aggagtggac gtcatctttc 2808361 atttggcggc cataccgggt gtccgctcaa gctggggcaa tcattttcac ccatatgccg 2808421 cacataatat ccaagcgctc caaaggctcc tcgaggcgtg ccgggaacat tctattcaaa 2808481 cgttcgtctt tgcatccacc tcttccgtct atggcgaaaa acaaggaaaa gtcagcgaaa 2808541 acacgtcgct ttctccttta tctccgtacg gggtaacaaa gcttacggga gaaaagcttt 2808601 gccatgtgta taaacagagc tttggcattc caattgtgat tctccgtttt tttaccgtat 2808661 acgggccaag acagcggccg gatatggctt ttcaccggct cattaagcag caccttcagc 2808721 aaaagccgct taccatcttc ggtgatgggc agcagtcaag agatttcact tatatcagcg 2808781 actgtgtcaa aggcatcacc gctgttcttg ggaaacccca ccttattggt gaaacagtaa 2808841 atatcggcgg cgcagagcgt gcctcagtct taaaagttgt ctccctcatt gaggatattt 2808901 ccgggagaaa agcaacactg cacttttcgg acaaaatagc aggggaaccg agcaacacgt 2808961 gggcggatat ttcaaaagca aaacagctct tgcattatga tcccgccaca tccttaaagg 2809021 atggcttgac caacgaaatc gcctatttat cgtcgctgta tcagggggaa taaaaatgaa 2809081 gcttgccttt atctgtacag aaaagctgcc ggcgcccgca gtacgcggcg gcgctattca 2809141 aatgatgatt gacggtgtca cgccctattt cagcagcagg tacgacctga ccattttttc 2809201 aatagaagat ccatcgctcc caaaaagaga aacaaaagac ggcgtacatt atatccatct 2809261 gccaaaagaa cattaccgcg aggcggtagc cgaagagctg cgagcctctt cctttgacct 2809321 cattcatgtg ttcaacaggc ctttaaatgt ctctttatat aaaaaagcct caccaaacag 2809381 caagatcgtt ctgagcctgc ataacgaaat gttttctgaa aaaaagatga ccttcgcgca 2809441 aggaaaagaa gtactcgaca atgtctccat gatcacaaca gtgagcgaat ttattaaaca 2809501 aaccgtcatt gaacgtttcc ctgaagccga ggacatcaca aaagttgtgt attccggcgt 2809561 tgatttaaac tcttatccgc ccgtctggac gatgaaaggc tcggctgtca gaaaaacata 2809621 ccggaaaaaa tacggtattg aagataaaaa agttatttta ttcgccggcc gcttaagccc 2809681 gacaaaaggg cctcaccttc tcattcacag catgagacgg attttgcagc agcaccctga 2809741 tgctgtactg gtcatagcag gcgggaagtg gttcagcgat gacagcgaaa accaatatgt 2809801 cacctatctg cgcacgctgg cgctgccata cagagaccac ataatcttta caaaattcat 2809861 tcccgcagac gatatcccaa acctttttct gatggcagat gtatttgtgt gcagctctca 2809921 gtggaacgaa cccctcgccc gtgtgaatta tgaagcaatg gcggccggca cgcccttaat 2809981 taccacaaac cggggcggaa acggtgaagt cgtaaaacac gaagtcaccg gccttgtcat 2810041 cgatagctac aacaaacctt cttcatttgc aaaagcaatt gacagagcct ttacagatca 2810101 agaattaatg aacaaaatga caaaaaacgc ccgaaagcat gtagaagctt tatttacctt 2810161 tacccatgct gccaaaaggc tcaatactgt ttaccaatcc gttctgaccc cgaaaaacaa 2810221 acaatttccg ccgccttttc tgacgcaaaa ttttgattta tcatctatca atcagctttt 2810281 tgtgaaagca aaaacataaa acctacagct cgtgttgcaa aacgggctgt tttttcgcta 2810341 cagagaactt aaaaaaaggc ataaatgtga ctttatgcct tgcgctttac agtttgagaa 2810401 aaccatggag ctggtttaga ttcacttgga agaatgatga tttccacttt agcttcttcc 2810461 gctaagtctg gttcttcatc ttcatcctct tcttcatatg ggggcgctga gcgtttcgaa 2810521 tcacgctcct cctcaggctc cagagtggtt tcgaattttg tttcttcttc atcatcgacg 2810581 attttgcgat ctgtttcctt ttccttcgtt tctttttgat attctttcgg tgcattgatg 2810641 tgagggagct ctcgaatgct gcccacatct aaatgcttct cctcttcttc cttctcagct 2810701 gagattgagt catgagcctg ccatcccatc ggtccaggcg gtgtaaatac gaattggtcg 2810761 agatccagtt tagaaataga ggctttttgt ctcgatgacc tcatgtcaat tcgcctcccg 2810821 atacgctttt atctttttat acagttccgg cagtttatcc aaaaacgaat ctttagattc 2810881 ttcaacagaa atcatgtttt gcagcgccca gttatacttc tcatctgacc acgttttctt 2810941 ttgcttcaaa taatatttgt gcccgattgc acagaacaaa tgcggaaacg cgagatcaat 2811001 ccaaagtacc tcgtactgtt tttctgtgag cggatacact gcgtcgtagg ccgcaagcag 2811061 tgcaaccatg aaatcagtat cccatacaga aagcttaacc atcactttat tcagcagaat 2811121 acgaaggtct cttgacggca aatcgtaggt aatcgagtga agctccttta aaaaaggctc 2811181 cccttcgatc tcagtcaaac gtgccaatgt aaaatcctga aaacagaatc cgccatgctc 2811241 gagtgtctct tttgtccagg tttcgtattc tgagtcatca agcgctctga gagcttcttt 2811301 tcctcttgcc agcattttat cagcatgttt taagaaagtt tgcgaaaata cgtcatcagg 2811361 ataggatgct gcgatctgca tattcccttc aagttcctgc agcttccaac ggtacaattt 2811421 gtgccatttt cccagcctgc ttctcttctt gctttcatct gtgcaaacat atccttttga 2811481 ggcatgatga aaatggccgg caaatgacat gacttttttc atttgctctg catcatagta 2811541 aatcatttct tttcctgtca ctttgtcata taaactgtaa gaaacctgat ccgtgcccaa 2811601 gcagctaccg ccattttttg tttgatgaat cggcgctatc ggcagccctt tctcttgtaa 2811661 atgggcgtgt gcctgagtga taaaaagcat ccgctccggt ttcatttgcg cttcttttag 2811721 cagctttggg ccatgatcag tttcgacttc ccagattttg cgcccgcttt tgttcgattt 2811781 cagcgccaca tggtcgatat gaaacggata ataactgaga atttcggaca caatctgttc 2811841 ttcatgctct ttttggtaca ctctgttcac cccttctatc tgttcttttc atagacgctg 2811901 agcagatttt cagccaccct ctgccagcca aaattgcttt ctgcctcacg gcggctgtat 2811961 ttcccaagcc gttcccgctt ttccgagctg ctcagcaaat cattgatacg ttcggcatat 2812021 tgtttaggat tttcaaagtc atgaatgatg tagccgtttt tcccttcctc tatgacctct 2812081 ggattgcctc cccgattgct tgtaataata ggaagtcccg cagccatcgc ttcataatgc 2812141 acccttgcta aaggctcctg ccattgcgaa gagcatacaa atacatctga catggtataa 2812201 aggcgcggaa tgtcctttgg cttcacaaat tgaataaatg tgacatgatc cttttgcatc 2812261 gcaccaaggg tatgaagatg tttgacatag ttatttaatt cattatctcc gaaccatttt 2812321 gacccgataa acaccatcat gacatcgggg tgctcctcaa tgatgtccgg caaagcctgc 2812381 aataatatgt gcgggccttt gactttgcta agccggccga caaacaagac gatttttttg 2812441 ccgtgaagcc ccagctcgct tcgcatctct tcgcgagctc gctgcccttc attcgtccag 2812501 cgagggtggt acgtttttaa atccacacca gaatacaccg tttttgtttt tgatcgtgct 2812561 gacggaaaac ggcttgtgat cgtctgtccg atataatcgc tgaccgtaac aatctgcgct 2812621 acggagtcga tgcaaatctc gccttccgcc tggctgattt tatcgtaagc gaacatttca 2812681 ttgtgaacgc ttaaaataaa aacagcatcc ggcgcctgtt tcttcaattt cggaacccag 2812741 cttgggcgat tacaaacatg cacaagatca aaacggctct ttttcagctc tgctccaacg 2812801 gcttcttcat aacggtcttc atccaaatgc acataatgga caccgtctac cttctctcta 2812861 tcagcgagat tcggatcttt aatagaaaac acagtcacct catgtttttt tgcaattaaa 2812921 ggggcaaccg cttcgaggta gatttgaatg gcgcctcctc gaaccgatgg gacaggaagc 2812981 ttctctgtgg cgatcagtgc tattttcata catagcctcc attcctgcat gatttttaac 2813041 tagttagaat catgatacgg ctgaacaacc aacttgtgcg gaatgggact gccctaaaaa 2813101 caaaacgggt aaacaaccag attcatctat taaatatagt caaataactc aatcattttt 2813161 tccttttgat tcataaggta ggagtaaaac aggtaaggat gtgtccttta atggcagaaa 2813221 accatgaagt cattgaggag gggaattcat cagagcttcc tttatcagca gaagatgcaa 2813281 aaaaattaac ggagctggct gaaaatgtgc ttcaaggatg ggatgtgcag gctgaaaaaa 2813341 tagacgtcat tcagggaaac cagatggcgc ttgtctggaa ggtccacaca gactccggcg 2813401 cggtttgtct aaaacgaata cacaggccag aaaagaaagc gttgttttcc attttcgcgc 2813461 aggactattt agcaaaaaaa ggcatgaatg ttcctggcat actcccaaac aaaaaaggca 2813521 gcctatattc taagcacggc tcatttctat ttgtcgtata tgactggatc gaaggaagac 2813581 cgtttgagct gactgtaaag caggacttgg agtttatcat gaaaggcctt gctgattttc 2813641 atacagcttc cgtcggatat cagccgccaa atggcgttcc catatttacc aaattaggtc 2813701 gctggccgaa tcactacacg aaacgatgca aacagatgga aacgtggaag ctgatggcgg 2813761 aggcggaaaa agaagatcct ttctcacagc tttatcttca ggagatagat ggctttattg 2813821 aagacgggct gcgcatcaaa gaccggcttt tgcaatcgac ctatgttcca tggactgaac 2813881 agctgaaaaa aagccctaac ctttgccacc aggattacgg aaccgggaat acactcttag 2813941 gagaaaatga acagatttgg gtcatcgact tagataccgt atcatttgat ctgcctattc 2814001 gcgatttgcg caaaatgatt attccgcttt tggatacgac gggtgtttgg gatgacgaaa 2814061 catttaatgt catgctgaac gcatacgaat ccagagcccc attaactgaa gaacaaaaac 2814121 aagtcatgtt tattgatatg ctgtttcctt acgagcttta cgatgtcatt cgcgaaaaat 2814181 acgtccgcaa gtctgcttta ccgaaggaag aattagaatc agcttttgaa tatgaacgca 2814241 ttaaagcaaa cgcattgcgg cagcttattt aagaccatca tttcccccgc atatcggggg 2814301 tttgatattt ataagataaa gggtaattaa atacatgcgg aggttgcaaa tatgaaaaag 2814361 attgtcggcg ctttagccgt ttttgtgatt acatatgcgc tgttttcagc cgcaggctac 2814421 ctgtttcctg tggaccaaga atggtacaat tcattgaaaa aaccggactg gacgccaagc 2814481 ggaactgcga tcggcatcat ttgggccatc ctgtttgccc tgatctccct ttcagcagcc 2814541 attgtatatg ctgcgttttc atttaaaggt gcgaaaagct tttggtttac acttttgata 2814601 aattacgtgc tcaatcaagc cttcagctat ttccagttta cgcaaaaaaa tctgctggct 2814661 gcatcgcttg actgcctgct tgtcgccatc acagcaatcg tattactgat cattgccaaa 2814721 aaatacagca gagccgcaag ctatcttctt ttgccttatt ttttatggag tgcatttgcg 2814781 acgttcttat cctttacaat caattcaatg aatctgtgaa caaaaaaagc cgcttataca 2814841 gcggcttttt cacatcatcg gcttgatgcc ccaaatgtcc ttcgcatatt cccggatcgt 2814901 gcggtcgctg gagaaatatc cagaatgagc aatgtttaca atcgaatgct cagaccattt 2814961 ccttcgctct cgataatcag cttgaattcg ctcctgtgca tctgcatatg agctgaaatc 2815021 cttcagcaca aaatactcat cattatgcgg aagcagcgag tcaaagatcg attcaaattc 2815081 atctgcctct ccttcaaaaa aaccattgat caactgatcc gctacctgcc tgattctcct 2815141 gtcatgctga taatattccc tcgacctata gccgccgttt tcctgatacg atagaacctc 2815201 atccgccttt aagccgaacg tgtaaataca gtcagggccc acccgctcaa ggatctcgat 2815261 atttgcgccg tcatgcgtgc cgatcgtcaa agccccgttc atcataaact tcatattccc 2815321 tgtaccagac gcttccttgc ttgcggttga aatttgctca cttacgtctg atgccggaaa 2815381 aattcgctca gccatagaaa ctctataatt ttctaaaaaa acaactttga tcagctgttt 2815441 gaccgccgga tcataattga ctttttctgc gacagaatgg atcagcttaa tgattttctt 2815501 ggcataataa tagcttggtg aagcctttgc cccgaaaata aaggtttgcg ggtagattga 2815561 aaaccccgaa tcctccttga ggcggttata caaatacata atgtgaagaa cattcagcag 2815621 ctgccgttta tatgcatgaa gccgtttcac ctgtacgtcg aatatgctct cagggttcac 2815681 aaccaccccg gccgtgcaaa aaatcaaatc ggcaagctct tgttttttct tgcttttgtt 2815741 gttttgaaac tgttcaataa atgcaggatc agtggcgtac ggttctaaac ggatcagtga 2815801 ttccggctgc ttgacccatt catcgccgat cgcctctgta atgatggcag acaagcctgg 2815861 attcgctttt aacagccagc gcctgtgggc aattccattc gtcttattgt taaaacgatt 2815921 cggaaacagc aagtgaaagt cgcgcatctc cctttccttt aatatatcgg aatgtatttt 2815981 tgcaacgcca tttacactgt agctgcctac tatggccaga tgagccattt tgacaacacc 2816041 atgcgctgta atcgccatgt tctctatcct tttccagtct ccaggatact tttcccaaac 2816101 tgcacggcaa aacctctcat tgatctcttc aataatcatg tacattcgcg ggagcagcgg 2816161 cttaaacaaa tgaatcggcc atttctcgag cgcttctgac aatgttgtat gatttgtata 2816221 agaaatcgta tgtacagtga tatgccaagc ttcttcccag ctcatgttct cttcatcgag 2816281 caaaatccgc attagctcag gcaccgcaag cgcagggtga gtgtcattaa tatgaatgct 2816341 cactttttta tgcaggccgg ataaagattt atgtgtttta cggtaattgt tcacaatgct 2816401 ttttaagctt gcgcatacta aaaaatactg ctgcttcagc cgtaaaattt tcccctcatc 2816461 atgggtgtca tcgggatata agaattcaga aaccgcttct gtttctcgct tataagacaa 2816521 aatattaccg ccgtgataat gggcataggg ctcggcgttc caaagcctta acgtgttgac 2816581 agtgcccgtt tcatagccga tgatcgggat atcataagga acagcggtaa caattgtcgc 2816641 ttgttcatgg cgaaaatgca ggcgcccgct tttttctgtc atatggactt cgccccaaaa 2816701 cggcacgtcc actgcttgat ccgcattcct tacttcccat acgttcccgt ttttcagcca 2816761 ttgctcaggc agctccacct gatgtccgtc tacaattttt tgctcaaaca aaccatgctt 2816821 ataacgtatg cccatgccgt gcccaggcag gttcaacgaa gcaagcgaat ctaaaaagca 2816881 agcggccaag cgcccaagtc cgccattgcc gagacctgca tcgttctcta tctgaaggat 2816941 ctcctctaaa ttgatgccga tttcctttaa accagcttct acaacatcac gaacaccaag 2817001 attcattaag ttttgctcaa ggagctgacc gagcagaaat tcgattgata aataatatgt 2817061 ctgcttcccg gaatttgatc tgcttttttc attcgtttcg atccaatcag cgctgatata 2817121 ctctctgacc atattgccca acgttttata ttgatccagc ttggcagaat ctttaaagct 2817181 ttttccgcac gtcatttcca gacgctttaa aaataagtct gcaaagcgtt ctttactcga 2817241 gaacatcccg tccactcctt gtcacctgct cgaaaatacg ctgatactct ttagccgact 2817301 tcccccagct gtaatctgca ttcatagcgg tcttcacgat gctcttccat acatcctgtt 2817361 ggcaataaaa cgacagcgcc ctttctatcg taaatttcag atcatgcgca ttaaaggcgg 2817421 aaaacgtaaa gccattgccc gttccctctt cctcctgata ggcacggaca gtgtcgtaaa 2817481 gaccgcccgt ttccctgaca atcggaatgg cgccatattg aagagcaatg agctgcccca 2817541 aaccgcacgg ctcaaatttc gacggcatca aaaacatatc agagcccgca taaatttgat 2817601 gggctagcgg ctcatcaaac ccgatataag cccggcactt ctcatgaaaa gcaaattctg 2817661 cataccggaa ataatcttca aattcacgtt ctcctgtgcc tagcacaacc agctgtatgt 2817721 cttgctcctc aagaagttcg tgcataattc tgcggacaag atcaagcccc ttttgtttag 2817781 tgagccttgt caccatactg atcagcggaa tatcgttttt ctctggaagc cccatccgct 2817841 gctgaagctt cgttttgttt tccagcttgc atgcaagatc ccctgaatcg tattgcgcct 2817901 ctatataagg gtcgcttttc ggctgataga acgtatcatc aatgccattt aatatgccgg 2817961 ttacatcatc ttccctatat tgcaaaacct gttccaactg ctcaccataa tacggcgtca 2818021 tgatttcatt tctgtaagtg gggctcacag ttgtcacatg atcagccgca atgatgcccg 2818081 ctttcataaa attaacaaat ccgttgcatt ctaacctttc ataatgaaaa tgatccatct 2818141 caagacccag caagtcatgt gtgacatcag gagggaatat gccttgaaac tgcaggttgt 2818201 ggatcgtgag cacgcttttc atccgttcat aaaaaggatg ttttctgtac tcctctttca 2818261 gcaaataatt gaccatcgct gtatgccaat cgtgagtatg aacaatatcg gcttgaacat 2818321 tcacaacttt ggcagcctcc agcacagctc ttgaaaaaaa ggcaaaccgc tcaccgtcat 2818381 cataatgccc gtacaacgaa tccctgttga aatagtactc attgtcgatg aagtaataat 2818441 tcacatcatt ctctgccata tgttcaattc cgcaatattg ctgccgccag ccgacagcta 2818501 cggtacactc agcctgtttt ttcatacgct ttttccacgg ttcaggtatt tggctgtact 2818561 tcggcagcat cacagctacc tcattgccta atcgcgcaag cgcctttggc agagcacctg 2818621 ctacatcggc aagacctcct gatttcacaa atggggtgca ttctgacaca gcaaataata 2818681 tcttcaagaa ttcatcagct ctccttgcac caaacctttt cttaatacaa gcggctgctc 2818741 agctgttcct gcagcttccg tcgccttgcc gattttaaca tccttatccg aaatgacctg 2818801 ctcaagaaga caatcctctc caatctgcgt tttttgcata ataatgcagt ttttcagctt 2818861 cgtacccttt ccgacatgga ccgccctgaa caaaatgcag ttttcaacct ctccttcaag 2818921 cacacagccg tttgccacca aagaattttt gacagtgctg tgctttccgt atttcgtagg 2818981 cggctcatcc ttcacttttg tatagatcgg ctgctgcggc aaaaacacct gctgccaaaa 2819041 acgaggctga atgagctcca tactgtgggt ataatatttt tccaccgaat caatgacagc 2819101 ggcataacct gaatattcat aagggcaaat ggtcagggcg gaagattcct tttcaacagc 2819161 ctcctgaatg gttttatagc ctttttcgct atgtccgtag atcagatcct ttaaaagcgt 2819221 tgttgacatg atatagattt gcagcgactg gccgtcctga aatacctcgg tgacgtcgca 2819281 gccaacctcc tgatggcgtt tcagcacata ttgaaattga atgttgcata cggtatggct 2819341 gttggagatt acagcatatt gctgagtgct tctgtggaag taatctagat ggtccgaaaa 2819401 ctggcgaaag gaaccgaatt catcgtattc gtgatgaaga tggggagacg ggaaaaaaaa 2819461 gaggccgtcc tttttccggt gcaaatccca ttccttaccc gccccaaggt gatccatgag 2819521 cgaacggtaa cgatacttcg gaaaaattgc aacactccta atatccgcat tcaccatgtt 2819581 ggaaagcata aaatcaatca gtcggtacct gccggcaaaa gggatcgccc cgagcgaccg 2819641 ctgtgctgtt aaatcctgaa gagaatgctt atatgtggtt tcatctataa cacctaacat 2819701 ttgattattg aacactgact ctgccccctc ttcagtaatt aaatcaattc tttttctaca 2819761 aattcctctg aaacgagcag cacctcttca atgtcttttt cggagcgaat cactgcgcca 2819821 tccggcagca ccatcccatt aggaacgatg gcattttcaa tgactacatg ctccccaatc 2819881 gtcacatccg gcattatgac ggatgatgta acagtcgtat gcttaccaac agtcacacct 2819941 tgaaaaagaa cggagtgaga cacatttcca tatacaacac aaccttcgtt cacaagcgaa 2820001 tcttgaacct gcgcatcaga tgaaataaat tgcggaggct gatttggatt gacggagtaa 2820061 attttccatt tgcgttcaaa cagcttcagc tccgagtcct cttttaacaa atccatattg 2820121 gcttcccaca agctctgcac cgttccgaca tccttccaat atcccttgaa cggataagca 2820181 gaaagcttct ttttctcttc caaaagcagt ggaataatgt ctttgccgaa gtcgtggcta 2820241 gaataagggt tttgatcgtc catctcaaga tactgtttca aaagcggcca attgaatata 2820301 taaattccca ttgaggcaag attgctctta gggaatttgg gcttttcatc aaaatgtgtg 2820361 atcgtcccat ctggattggc cttcatgatg ccgaaccggc ttgcttcctc ccagcccact 2820421 tcgatgacag agatggtcac atctgctttc ttttcaatgt gataatcaag cattttgccg 2820481 tagtccattt tgtatatgtg atctcctgat aaaatcagta catactcagg atcatactga 2820541 ttcaaataat tgagattttc ataaatggag cttgccgtcc ctttatacca tttgacttct 2820601 gatgactcgg cataaggggg taaaaccgtc acgccgccat tatatctatc caggtcccat 2820661 gcactgccga tcccaatata ggaattcagc tcgagcggct gatattgcgt taaaatcccg 2820721 actgtgtcta tgcctgaatt agaacagttg cttagggtaa aatcaataat cctgtatttt 2820781 cccccgaaag atacagccgg tttggccata ttttttgtta atccgctgag acggctgccc 2820841 ttcccgccgg caaggagcat ggctacacat tgttttttca tctttttatc tctcctcttt 2820901 ttttaaccgc ccgtaaaatc gagatgccgt aaggggggat ggtcatcgtg atataacacg 2820961 gtttatgatg aagtgctccc tttttagccg ataacggctt tttgttgatt tgccctgagc 2821021 ctccatatgt ttcactgtca ctgttaagca cttcaatgta ttgagtaaaa aaaggaactc 2821081 caacatcata ttgatgatag accacgggtg taaaattaca aatgatgaca agcgcctcac 2821141 cgtgcttttg gccataacga ataaaagaaa agattgattg ttcgtcatta tggacatcaa 2821201 tccattcaaa cgattgtgca cgatggtcat gctcataaag gattttgctt ttttggtaaa 2821261 agcggagaag atcttgcgta aaaacgctgg ctttctgatg catggggaag gagtccaaaa 2821321 accaatcaag ctgttctgta tctttccatt catcaaattg agcaaactct gatcccataa 2821381 agatcaattt ctttccggga tgcactgtca tatagcccag caaaagccga tactgggcaa 2821441 atttctgcca gtagtcgcca ggcattttat tgagaagtga tttttttccg tatacgactt 2821501 catcatgaga aaacggcaat acaaaatgtt cactaaacgc atatagtaat gaaaaagaga 2821561 taagctgatg acaatgccgc ctttcttcgg gcggcgtctc catgtatttc agtacgtcat 2821621 tcatccatcc catattccat ttataatgaa aaccaagccc cccttcctca acggcacctg 2821681 tcacttgagg ccattctgta gaatcttctg caatcatcat cacatgggga tatgcctctc 2821741 tcatggtttg attgagtttt tttaaaaaat caacagcata tggattcgtg tggcgttcat 2821801 cctgatttgg ccaatacaag atattagcca ctgcatcaac cctaaatcca tctatatgat 2821861 agaattccgc ccagtacaac gcattcgaaa ttaaaaaact atgaacttcc ggtttcccca 2821921 ggtcaaagtt tgccgtgccc cataaccagt tctcccgatc acgttcttct ttgtattcat 2821981 aaagcggttc tccatcaaac atataaaggc catgtgcatc tttacaaaaa tgtccgggga 2822041 cccaatccaa aatgactccg atattttgtt gatgacattc atccacaaac ttcatcagat 2822101 catgcggcgg gccaaacctg cttgtcgggc tgtaataccc cgttccttgg tacccccatg 2822161 aacgatcata tggatgctca tacacgggaa gcagttcaat atgggtaaac ccatgcttct 2822221 tgatataagg gataagcgtc tgacttaatt ctttatagga ataatgcctg ccatcagaat 2822281 gcttcttcca agacccaaga tgcagttcat aaatgaaaac aggtttttca tacagcgtct 2822341 tagccttctg tttcttttgc catttttgat cttgccagct gtatccttcc aaatcgtaag 2822401 taagtgacgc tgtgtttggt ctgacttctg aataaatagc gtatggatct gccttcagcc 2822461 tgatctcacc gttattcgtc acaatttcgt atttatatcg ttccttttct cctatacctg 2822521 gaataaataa cgtccaaatg ccattatcat tcactctgtg catcacatgc tcttctccag 2822581 accagctgtt aaaatctcca gccactcgta cttccgacgc atgaggcgcc cacacacaga 2822641 attcatatcc gcttttgcca ttcagctcgc ggtaatgcga gccaaacagc tgatagcttt 2822701 taaacagact gccttcgtga aaaagataaa catcatgtgc tgtcgggctg gcagcggcca 2822761 tgtaatcatc ctttctgaca tcatagtttt catttatagt atttattcga agaaataaaa 2822821 aaaagccctt tcctgaaagc gcttatactt atagacaatt aacttcattt tctgaagaaa 2822881 aacgaaatat atggagattt ttgtagtctg tttttaaaat aaagaacaaa atctaagaca 2822941 tatcatgatt tataaaaaca aaaaaacctt gcaggatatg caaggcttct ggatgacccg 2823001 tacgggattc gaacccgtgt taccgccgtg aaagggcggt gtcttaaccg cttgaccaac 2823061 gggccgataa ttatgatatc tgtaatcata tggcggagaa ggagggattt gaaccctcgc 2823121 gccgcttaca cgacctacac ccttagcagg ggcgcctctt cagccacttg agtacttctc 2823181 catttggctc cacaggcagg attcgaacct gcgaccgatc ggttaacagc cgatagctct 2823241 accactgagc tactgtggaa caaaagtcat ggtgggcctg aatggactcg aaccatcgac 2823301 ctcacgctta tcaggcgtgc gctctaacca gctgagctac aggcccatga cgatatagaa 2823361 atggagcggg tgatgggaat cgaacccacg acatcagctt ggaaggctga ggttttacca 2823421 ctaaactaca cccgcaattt ttatttgggg cgattgatgg gaatcgaacc cacgaatgcc 2823481 agagccacaa tctggtgcgt taaccacttc gccacaaccg ccaaagcata ttgataaatg 2823541 gtggctcggg acggaatcga accgccgaca cacggatttt cagtccgttg ctctaccaac 2823601 tgagctaccg agcctaagta tttaaatggc ggtccggacg ggactcgaac ccgcgacctc 2823661 ctgcgtgaca ggcaggcatt ctaaccaact gaactaccgg accattttaa aatttggttg 2823721 cgggggcagg atttgaacct gcgaccttcg ggttatgagc ccgacgagct accgaactgc 2823781 tccaccccgc gatgattagg aatatgtatg gcggaggaag agggattcga acccccgcgg 2823841 gctttgacac ccctgtcggt tttcaagacc gatcccttca gccagacttg ggtattcctc 2823901 cgtatagtgg tggaccttgt aggactcgaa cctacgaccg gacggttatg agccgtctgc 2823961 tctaaccaac tgagctaaag gtccattggt agcggcggag gggatcgaac ccccgacctc 2824021 acgggtatga accgtacgct ctagccagct gagctacacc gccaaatatt tttgaaatca 2824081 agtggagcct agcgggatcg aaccgctgac ctcctgcgtg caaagcaggc gctctcccag 2824141 ctgagctaag gccccaagaa tggtcgggaa gacaggattc gaacctgcga ccccatggtc 2824201 ccaaaccatg tgctctacca agctgagcta cttcccgatt tcatatagat catggcgcgc 2824261 ccgagaggag tcgaacccct aaccttttga tccgtagtca aacgctctat ccaattgagc 2824321 tacgggcgca aaacttaatg ccgagggccg gacttgaacc ggcacggtag tcacctaccg 2824381 caggatttta agtcctgtgt gtctgccaat tccaccaccc cggcgtggat ggtatagttg 2824441 gagcggaaga cgggattcga acccgcgacc cccaccttgg caaggtggtg ttctaccact 2824501 gaactacttc cgcagaaatg gtgcggatga agggacttga acccccacgt ctgtaaagac 2824561 actagagcct gattctagcg cgtctgccaa ttccgccaca tccgcaacat gtaaatggtg 2824621 agccatgaag gactcgaacc ttcgaccctc tgattaaaag tcagatgctc taccaactga 2824681 gctaatggct cttcttacaa tagacttgaa tattatatca tataaaagtg gtgccggcaa 2824741 gaggacttga acccccaacc tactgattac aagtcagttg ctctaccaat tgagctacac 2824801 cggcatatat gtaaaaccga tatgtataat gaaaaatggt ggaggatgac gggctcgaac 2824861 cgccgaccct ctgcttgtaa ggcagatgct ctcccagctg agctaatcct ccatacttgc 2824921 actaacgtgc aattgcttgg cggcgtccta ctctcacagg gggaaacccc cgactaccat 2824981 cggcgctgaa gagcttaact tccgtgttcg gtatgggaac gggtgtgacc tcttcgctat 2825041 cgccaccaaa caaattgaga gtgttctctc aaaactagat aacaggtgtg acatcattca 2825101 aaaatatggt taagtcctcg atcgattagt atctgtcagc tccatgtgtt gccacacttc 2825161 cacctcagac ctatcaacct gatcatcttt cagggatctt acttccttgc ggaatgggaa 2825221 atctcatctt gaggggggct tcatgcttag atgctttcag cacttatccc gtccgcacat 2825281 agctacccag cgatgccctt ggcagaacaa ctggtacacc agcggtgcgt ccatcccggt 2825341 cctctcgtac taaggacagc tcctctcaaa tttcctgcgc ccgcgacgga tagggaccga 2825401 actgtctcac gacgttctga acccagctcg cgtaccgctt taatgggcga acagcccaac 2825461 ccttgggacc gactacagcc ccaggatgcg atgagccgac atcgaggtgc caaacctccc 2825521 cgtcgatgtg gactcttggg ggagataagc ctgttatccc cggggtagct tttatccgtt 2825581 gagcgatggc ccttccatgc ggaaccaccg gatcactaag cccgactttc gtccctgctc 2825641 gacttgtagg tctcgcagtc aagctccctt gtgcctttac actctgcgaa tgatttccaa 2825701 ccattctgag ggaacctttg ggcgcctccg ttacctttta ggaggcgacc gccccagtca 2825761 aactgcccac ctgacactgt ctccccgccc gataagggcg gcgggttaga aggtcaatac 2825821 agccagggta gtatcccacc gatgcctcca ccgaagctgg cgctccggtt tccaaggctc 2825881 ctacctatcc tgtacaagct gtaccaacat tcaatatcag gctgcagtaa agctccacgg 2825941 ggtctttccg tcctgtcgcg ggtaacctgc atcttcacag gtactataat ttcaccgagt 2826001 ctctcgttga gacagtgccc agatcgttgc gcctttcgtg cgggtcggaa cttacccgac 2826061 aaggaatttc gctaccttag gaccgttata gttacggccg ccgtttactg gggcttcaat 2826121 tcgcaccttc gcttacgcta agcgctcctc ttaaccttcc agcaccgggc aggcgtcagc 2826181 ccctatactt cgccttacgg cttcgcagag acctgtgttt ttgctaaaca gtcgcctggg 2826241 cctattcact gcggctctct cgggcttgca ccctaacaga gcaccccttc tcccgaagtt 2826301 acggggtcat tttgccgagt tccttaacga gagttctctc gatcacctta ggattctctc 2826361 ctcgcctacc tgtgtcggtt tgcggtacgg gcacctctca cctcgctaga ggcttttctt 2826421 ggcagtgtgg aatcaggaac ttcgctacta tatttcgctc gccatcacag ctcagcctta 2826481 tgggaaacgg atttgcctat ttcccagcct aactgcttgg acgcggatat ccaataccgc 2826541 gcttacccta tcctcctgcg tccccccatt gctcaaatgg tgaggaggtg gtacaggaat 2826601 atcaacctgt tgtccatcgc ctacgccttt cggcctcggc ttaggtcccg actaaccctg 2826661 agcggacgag ccttcctcag gaaaccttag gcattcggtg gaggggattc tcacccctct 2826721 ttcgctactc ataccggcat tctcacttct aagcgctcca ccagtccttc cggtctggct 2826781 tcacagccct tagaacgctc tcctaccact gttcgaagaa cagtccgcag cttcggtgat 2826841 acgtttagcc ccggtacatt ttcggcgcag agtcactcga ccagtgagct attacgcact 2826901 ctttaaatgg tggctgcttc taagccaaca tcctggttgt ctaagcaact ccacatcctt 2826961 ttccacttaa cgtatacttt gggaccttag ctggcggtct gggctgtttc cctttcgact 2827021 acggatctta tcactcgcag tctgactccc aaggataagt cattggcatt cggagtttga 2827081 ctgaattcgg taacccggta ggggccccta gtccaatcag tgctctacct ccaagactct 2827141 taccttgagg ctagccctaa agctatttcg gagagaacca gctatctcca ggttcgattg 2827201 gcatttcacc cctacccaca cctcatcccc gcacttttca acgtgcgtgg gttcgggcct 2827261 ccattcagtg ttacctgaac ttcaccctgg acatgggtag atcacctggt ttcgggtcta 2827321 cgaccacgta ctcatgcgcc ctattcagac tcgctttcgc tgcggctccg catcttctgc 2827381 ttaaccttgc acgggatcgt aactcgccgg ttcattctac aaaaggcacg ccatcacccg 2827441 ttaacgggct ctgactactt gtaggcacac ggtttcagga tctctttcac tccccttccg 2827501 gggtgctttt cacctttccc tcacggtact ggttcactat cggtcactag ggagtattta 2827561 gccttgggag atggtcctcc cggattccga cggaatttca cgtgttccgc cgtactcagg 2827621 atccactcag gagagaacga agttttgact acagggctgt tacctcctat ggcgggcctt 2827681 tccagacctc ttcatctacc tcgttctttt gtaactccgt acagagtgtc ctacaacccc 2827741 aagaggcaag cctcttggtt tgggctgatc ccgtttcgct cgccgctact cagggaatcg 2827801 catttgcttt ctcttcctcc gggtacttag atgtttcagt tccccgggtc tgccttctca 2827861 tatcctatga attcagatat ggataccact ccattacgag tggtgggttt ccccattcgg 2827921 aaatctccgg atcaaagctt gcttacagct ccccgaagca tatcggtgtt cgtcccgtcc 2827981 ttcatcggct cctagtgcca aggcatccac cgtgcgccct ttctaactta accgttaaaa 2828041 agaatcacta tgtgatatct tgtgttacta attgaatgtg atgtctactg ttatctagtt 2828101 ttcaaagaac acgtttcgaa ggaatgatcc ttcaaaacta aacaagacag ggaacgttct 2828161 gtttataaga ccttgggtct tatattccgt ataatatcct tagaaaggag gtgatccagc 2828221 cgcaccttcc gatacggcta ccttgttacg acttcacccc aatcatctgt cccaccttcg 2828281 gcggctggct cctaaaaggt tacctcaccg acttcgggtg ttacaaactc tcgtggtgtg 2828341 acgggcggtg tgtacaaggc ccgggaacgt attcaccgcg gcatgctgat ccgcgattac 2828401 tagcgattcc agcttcacgc agtcgagttg cagactgcga tccgaactga gaacagattt 2828461 gtgggattgg cttaacctcg cggtttcgct gccctttgtt ctgtccattg tagcacgtgt 2828521 gtagcccagg tcataagggg catgatgatt tgacgtcatc cccaccttcc tccggtttgt 2828581 caccggcagt caccttagag tgcccaactg aatgctggca actaagatca agggttgcgc 2828641 tcgttgcggg acttaaccca acatctcacg acacgagctg acgacaacca tgcaccacct 2828701 gtcactctgc ccccgaaggg gacgtcctat ctctaggatt gtcagaggat gtcaagacct 2828761 ggtaaggttc ttcgcgttgc ttcgaattaa accacatgct ccaccgcttg tgcgggcccc 2828821 cgtcaattcc tttgagtttc agtcttgcga ccgtactccc caggcggagt gcttaatgcg 2828881 ttagctgcag cactaagggg cggaaacccc ctaacactta gcactcatcg tttacggcgt 2828941 ggactaccag ggtatctaat cctgttcgct ccccacgctt tcgctcctca gcgtcagtta 2829001 cagaccagag agtcgccttc gccactggtg ttcctccaca tctctacgca tttcaccgct 2829061 acacgtggaa ttccactctc ctcttctgca ctcaagttcc ccagtttcca atgaccctcc 2829121 ccggttgagc cgggggcttt cacatcagac ttaagaaacc gcctgcgagc cctttacgcc 2829181 caataattcc ggaaaacgct tgccacctac gtattaccgc ggctgctggc acgtagttag 2829241 ccgtggcttt ctggttaggt accgtcaagg taccgccctg ttcgaacggt acttgttctt 2829301 ccctaacaac agagctttac gatccgaaaa ccttcatcac tcacgcggcg ttgctccgtc 2829361 agactttcgt ccattgcgga agattcccta ctgctgcctc ccgtaggagt ctgggccgtg 2829421 tctcagtccc agtgtggccg atcaccctct caggtcggct acgcatcgtt gccttggtga 2829481 gccgttacct caccaactag ctaatgcgcc gcgggtccat ctgtaagtgg tagccgaagc 2829541 caccttttat gtttgaacca tgcggttcaa acaaccatcc ggtattagcc ccggtttccc 2829601 ggagttatcc cagtcttaca ggcaggttac ccacgtgtta ctcacccgtc cgccgctaac 2829661 atcagggagc aagctcccac ctgtccgctc gacttgcatg tattaggcac gccgccagcg 2829721 ttcgtcctga gccaggatca aactctccga taaatggatc acaggttaag ttcaccgcat 2829781 cctgcggcga cacctgtgtg acctgcgtcg tgcaggccct agtttgactg actacgcaca 2829841 tcgcagtgcg atttttaaaa actgaattaa caggtacgtt ttgtcttgtt tagttttcaa 2829901 agatcatttc gttacttctc aatgaagcag ctttactaat ataacattca gcttcttttt 2829961 tgtcaacaac ttttttcaag ttgttttgaa gcatctagtt tgtgtccgct gtgcatcagc 2830021 gacgtttaat aatataacac ctgtatttat ttattgcaat agttttttaa aaaaaatcta 2830081 taaaacaaat aaactataat cctcgccatg atttctaaag cgtgtgtatc atataagttt 2830141 cttaaaagaa catatacatc agtcatgtga tcttgttgtt tttttcgttt tcttgtatag 2830201 tagaaacgaa ctaaatactg atgaccacaa ggggagcatt aaagctgaga gtgagcggtt 2830261 tcgttctgac cctttgaacc tgttagttaa cgctggcgta gggatgtggc aaagtcaaat 2830321 gaattgcaga tcgtaaagca gtgcgtggaa cttttctcat ccttccgcgt gctgcttttt 2830381 tgttgtcctt ttggttgtct gtcaatggaa ggagatagat atgaatcaat ctaagcaact 2830441 ggttcgcctt attgaaattg ccattatgac agcggcagcc gttattttag acattgtctc 2830501 aggaatgttt cttagcatgc ctcaaggagg ctcggtctcc atcatgatga ttccgatctt 2830561 tttaatttcg tttcgctggg gtgtcaaagc aggtcttact acaggtttgt tgacaggtct 2830621 agtacaaata gcaatcggaa acttgtttgc tcaacatcct gtacagctat tgttagatta 2830681 cattgtcgct ttcgcagcaa tcggcataag cggctgtttc gcttcttctg tccgtaaagc 2830741 cgctgtatca aaaacaaaag ggaaattgat tgtttcagtg gtcagcgcag tttttatcgg 2830801 cagtttgctg cgctatgccg cgcatgtcat ttcaggagct gtgtttttcg gcagctttgc 2830861 tccaaaagga acaccggtat ggatttattc tttaacttat aatgcgactt acatggttcc 2830921 ttcattcatt atttgtgcaa ttgtcctatg tttattattt atgacagcac cccgtctgct 2830981 taaaagtgac aaagcgtaaa agtaacaatc ccccagcgaa ttccgctggg ggatttttcg 2831041 ttatctgtta agaagtgttt ttaaagctga aagatccggc cagccaagac ctacttcttt 2831101 cagccttact ccggcaattt caaagttgtc ctccgctact ctttcaggtg aataggcctg 2831161 ataaaatata atcgagggat tctgctcaat aacccaaaca aacatacttg aaaaaccatg 2831221 ttgaagcaaa aactccgctc cttttgctaa gagcgccctg cctgcacctt gccgctggcg 2831281 ctcttccaga agataaatag cgtataactc gccgtcatag ccttcttgtt cagagcgaat 2831341 aggtccaaat gaagcaaagc cgaatactga acccttttcg tcctgagcaa caaatactcc 2831401 ctttaacgag cgacttttcc atttgtcttc aaattcctta tagttcaggc tgtttaaata 2831461 atcaatcggg ataatttcgt ggtatgttgt cctccagctg tctacatgca cttttgcaat 2831521 gtcctttata tcctctaact tcgcttcacg tacagttacc atacggttct gccctttcct 2831581 tactctgatt tttggatcgt tttggcttct ttgatttcat ttgttaattc attaatgctt 2831641 tgttttacgt ttccttttcc tgaaaagttc tcaagcattt cttttacatc aattcctgag 2831701 gatgctttta aactttcttg cagacttgac attaagttcg tcgcatagct ggttactttg 2831761 tttgctccgc ttgattcacc gcttcctcct gtatcgacaa cggtgatttt atcaatattt 2831821 gaaagaggtg ccgctgcttg tttcgcgtat tccggaagca ttttgacaat catatcgaaa 2831881 atcgccgcct gcccgtactg ttcaaaggcg gccgcaattt tctcttttgc ttccgcttct 2831941 gcaagacctt tcaggcggat aacctctgct tctgtctctc ctttcgcttt ttccgcttct 2832001 gcttttgcta gcccgtcaat tcttactttt tccgcctcag cctttgccat tgcttcaata 2832061 ctgtacttct tggcatcggc ttccgcgagc tgtttggctt tctcagctgc tgcggactgc 2832121 tcaacagaat aacggtctgc atcggctttt ttctttacct ctgagtcgta ttgacgttca 2832181 cggcgaagaa tttctttttc ttctagttct atttgttttt ggcgttcgat aattttaacc 2832241 tgcatttcct gctctgtgac ttgctggcgc gctcgggcag tctctaaatc atatgcttgg 2832301 tcggcattcg cttttgccgt atcttgttct ctgcggaatt cagccatttt gagctgattg 2832361 attttttcag cttcagcgat ttccgtcgcc cgttcaagtt ctgatttttt tgcgtcttta 2832421 tcggcttctg cccgcttaat tcgggtttct ttatcagcct ctgctgttgc gatatcagca 2832481 tcgcgtttta cttgggcaat tctcggtttc cctaatgatt caagataacc gtttttatca 2832541 cgaacatctt taatggtaaa cgagacgatt acaagtccca ttttcgcgag atcctgtgaa 2832601 gcgacacgct gcacctcttg agagaatttt tctctgtttt tatagatttc ttctactgtc 2832661 attgagccga gaatggaacg aaggtggcct tctaaaacct cccgcgcttc ctgctcacgg 2832721 tcgtcttttg atttccctaa aaattgttcg gccgctgtag cgatttctcc tatagaaccg 2832781 ccgattttaa taatcgcagt tccatcggcc attactggca ctccttgttc tgtatagact 2832841 tcaggtgtcg aaacatcgag tttgcttgat aataggctta gcggctctgc ctgctggaag 2832901 acgggaagga caaaggttcc tccgccgcgg acgattttaa tacggttgcc gccttcatcg 2832961 acatgaacat ttttattacc cagatagctc cctgttacaa ttaacgcttc atcaggccct 2833021 gctgtacgat acttcgtaat aaacacagct attagtgcaa ttaataaaaa gaatacaact 2833081 ccgatgatca ttataatcgg cattgtcata tcaaattcct ccttttatgt taaatgggtt 2833141 catgcggagt aaccgaaaga actccgttgt taatatctac gactaacacc gttgtcccgt 2833201 aactgatctg ctgattatca aaactgaccg ctgactttga aatggtcccg cctatccctt 2833261 ctatgaccac ttcaccaaac ccgtcaaccg gcacagctgt aatcacttta ccgagtcttc 2833321 ctctgagatc atcttctcta tatgccaatg attcttctgc agatgataat ggcaccagta 2833381 caaagatgtg aagcaatacc accagcatga tcgaaaggat gcaagataaa agcgcaatca 2833441 gcaagcttga cagaggcaat acaagttcac ctatatatcc gcccgctgaa aaacatgtaa 2833501 aaaatgagag cactaatgtc ggattaagaa acggaatgcc ttctgacagc cctgaaaata 2833561 catctccgaa aaacaggaat aacagcgtaa ggctgcccgc aataataagc gtataaagat 2833621 acattgtttg tataggtact ccaaataact ccaacttcct catcctttct tcatcaatgc 2833681 attgatgaac ggctgccgtt accatttata cgagacacct cgggaaaagt ttcaaaattt 2833741 taagacaaat aacccatttg aagtgcttta taaatgataa ttgcttatat atatggtaat 2833801 gtcattttag gaggagatat gatgagtatc tttaatgaag ccagattaga aacgtggaac 2833861 gaattgaaag gactttctga cgaaaagctg aatcaaaagc cttctgctga agaatggagc 2833921 atacgggaag ttcttgacca tttgaaaaaa atcgatatga ccgcacaaaa aatgttgaag 2833981 gaacgtgtaa aggacgctcc gattaaagaa attgaagaaa aaccgcttga agtagcacag 2834041 gacagaaata ataaacggaa agccccgagt catcttgagc ctgcgcatga ttttatttca 2834101 ggcagccaaa tgaaacgtga gcttgatgtg gtaagagagc agctgactgc tgcgattgcc 2834161 tctctgaaag aagaagattt tgaaagagtg cttccgcatc ctgtgtttca agagctgact 2834221 gtcagacagt ggatcgattt tatcggccat catgaaaaac ggcacctcag ccaaatgaaa 2834281 gaaattaaag aaaagataga aagggcctga tttaatcaga ccctttctgc ttttcgtttg 2834341 acttttcgct gataggaatg aacttctatt tcatcacctg tgtaaacagc accaggtctc 2834401 tccacaatac agacaatccc tctaatgccc agtgcgtggc ggacgaaagc cgacgccagc 2834461 ttcggttggt ccggataata agactgaatg acttctcccg gctggataca cggatcattt 2834521 tcgccctcac acagcagagc cgctccgctc ggaaaaataa tccggcttcc ttcttttaat 2834581 gaagtaagat ctggcatacc gctgactgcc acattcgccc cgagccattc cggcaaaatt 2834641 ctcggcactc ccatttttaa agcgatttcg ttgcattcct ctattgaaac aattgaaatt 2834701 tgtctgcggt tgaaaatttc agtccctctt gaaaacattg gttctctggc tcccgctttt 2834761 ttggtcaggc caaaatgcaa gtcgccgggg atgccgccat aatcaaaatc aagcttgtcc 2834821 atttgctttg ttacgaagct ttttgtatct gcgatatata agccttccgc ttttgcagtc 2834881 atacgcttcc acatcagctg gcaccttcct tcttatctaa aatttccacc tatgcttcat 2834941 tatcccaaaa aatcccgctc tgtaaaggag cgggattttg attataccgt tttaggcgta 2835001 aggttaaagc agcgtttgta gatccagttg tatgcttttt catttaaatc tctagggttt 2835061 ccgaaggttt gcggatcttt cattgcttct ttagacaagc gttcgatcat atcaggtgat 2835121 actccctgct cttctaaagt cggcacttct aaatcttcga ccagatcata catccaattg 2835181 acagatgctt tcgcagcttc ttctgttgtc atcttgcttg tatcaatacc gaacgctttc 2835241 gcaatacgcg caaacttctc aggatagccc ttccagttgt attccatgac agggcccatc 2835301 atcgccgcta cacattggcc gtgagcgact gggataatac cgccaagcgt ttggctcatc 2835361 gcatgagcag cgcccgctga ttcacttccg taagaaagac cggcaagcat cgcagcctgc 2835421 gccattccgt accttgcttc cagatcctct ccatcagcaa atgccctctt gatgtaatga 2835481 gcggcatact caatcgccat taaggcaacc gcatccgtga ttggctgtgc aaatttcatt 2835541 gtatagcact caatggcatg ggcgagcgca tcaattcccg tcatagctgt tacatgcgga 2835601 ggcattgaaa catgaagctc aggatcaatg attgtcaagt gcgctgcaat cagcggaccg 2835661 cccgtgttga atttgaattc tctttcttca tctgtgataa ccgcccattg ggttacttct 2835721 gatccggttc cagctgtagt gggaattgtc gtcagcggag gaatgcggtt ttccagcggt 2835781 tttttcccat ctgccgcttc ataatcaagc acgcttcctt cgtgagtcgc ttctactccg 2835841 attgcttttg ctgtatccat ggagcttccg cctccgactg ccaccaaacc attacagttc 2835901 tcttttttgt aaagctcaga tccttcattc accagacgga caggcgggtt tggctcaact 2835961 ttattaaaga gtaccacttc aatgcctgct tctttaagtg attcgattac gggatcagca 2836021 acaccggctt tataaatccc agggtctgtg acaaggagcg cttttgaaac gcccagtgca 2836081 gctacttcct cacccgtatg cttgatggct ccgattccat gcttaatcac agtcggaatt 2836141 tcaaatgtgt ggaatttctg catgctttct accttcatat ttaatgtcat catcaatctc 2836201 cccctcttat gaattaaacc agttaaccgc tgccggtttt gtattgcggt atacatgttt 2836261 gacttctgtg tattcttcaa ggcctatttt tccaagctcg cgtccgaacc cggattgctt 2836321 atatccgccc catggcgctt gtgcaaagta cggatgaaaa tcgttgatcc aaacggttcc 2836381 cattctcaag cgggctgcta cccgttcgca cttttcaatg tcttttgacc ataccgctcc 2836441 agccaagcca tagatggtat cattcgcaag ctcgattacc tcttcttcag agctgaaggt 2836501 ttcgactgtc aatacaggac cgaaaacctc ttcctgaacg attctcatgt cagaattaca 2836561 gtttgagaaa atagtaggtt catagaaaaa gccgttttga agctcaggat cttccgggcg 2836621 tttgcctcct gtctccagct tcgcgccttc ctctattccg atctctacat atttttctac 2836681 ctttgccctg tgctccgccg aaataagcgg accgctttct gtctcagcat gaaaaccgtt 2836741 tccgagtttt atgcgttttg cccgtttgac cagctccgcc aaaaattgat catgaatggc 2836801 atcctcaaca agcaagcggg aacctgcaga gcatacttgg ccggcgtgga aaaatacagc 2836861 gtttaaggcc tgatcaaccg caacttctaa atccgcgtcc ttgaaaacaa tatttgggtt 2836921 tttcccgcca agttcaaggg cgattttttt gacgtttccg cttgccgccc gcatgatttt 2836981 tttgcctgtt tcaattccgc ccgtaaatga aatcaaatcg acgtctttgt ttacggcaag 2837041 ctcgtcgccc actgtggctc ccggtccaag aacaagattt gcgacacctt ttggaacacc 2837101 ggcttcttcc atcagcttaa agactttgat tgtcgtcagc ggcgtaatct cactcggctt 2837161 catgacgatt gtgtttcctg cggccagtgc aggggcgatt ttccagctcg cttgaaggag 2837221 cggataattc catggagtga tctggccgca aaccccgatt ggctccctaa taattttgct 2837281 ttctgaatca ggaatcggag atgaaatgat ctctccgcca tctttgtctg ccaagccggc 2837341 gtaatattga aaaacattgg cgatatcgtc catatcggcc ttgctttctt cgagtgtttt 2837401 tcctgtatca agagattcaa gctcagccag ctcctcaaga tcgcgtctga ttaattccgc 2837461 aattttcaga acaatttttc cgcgttcaag cccggatagc gatgaccatt ctcctttgtc 2837521 aaatgctcta cgtgcggctg cgattgcttt gatggcgtcc tctcgccctc cctcgcttac 2837581 agttgcaatt tcttcttgat taaatgggtt gataatactg cggatctgtt ctttttcggc 2837641 actgatccat tctccgtcaa tgaataatgt ttgactcata taagcctcct tgacgtaaat 2837701 aaagtttgtt aaataaaaat ttaatgtttt taacaacctt aatctaacat atggttttta 2837761 aactgtcaaa gtcccatttt gatttttctt tttgactttt cctcatgttt cgttaagata 2837821 aagaacataa agaaataact taacgaattt aattttctaa aggaaaagag ggtcagtatg 2837881 gatgaaaatc cagaatttgc agctatagaa caggctcggg atcttgttat tgactccatt 2837941 gctgaaacga tggatcttta cggaattacc cgcagtgtcg ggattttata tgggacgatg 2838001 tatatgaggg atgagatgac gcttgacgaa atgcgtgagg agttgcaaat gagcaaacca 2838061 agcatgagca ctggcgtcaa aaagcttcaa gacttaaatg tagtgaaaaa aacatttcac 2838121 cggggcatcc gcaagcatac atttgtggct gagaaggatt tctttaaatt tttcacaaat 2838181 ttctttccac ctaaatggga gcgggaggtt caagtgaatg taacagcgat cgaggaagct 2838241 caagctgatt tacaaaaggt tttatgcaag gaagatctcg atgaggatat caaaaatgaa 2838301 gcactgcagt tatatgatca gctggaaagc tctaaagctt actatgactg gctgaaacgg 2838361 cttgctgaat cggtgcagac cggagaaatt tttaaattta taccggtcga aacaaagtaa 2838421 agcagaaaac gcctgggaaa ctaggcgttt ttttgatgta actactacaa atttgaaaaa 2838481 tacgggaaaa acaccccatt tacttccaaa atatttgatg gtaattttat gtaggtaaaa 2838541 tttgtatttg gcctttcaga ggaggtgaaa agcgggcagg cctgtttaat ttatcatttt 2838601 ttagggggaa ttttgttatg aaacgcaaat tattatcttc tttggcaatt agtgcattaa 2838661 gtctcgggtt actcgtttct gcacctacag cttctttcgc ggctgaatct acatcaacta 2838721 aagctcatac tgaatccact atgagaacac agtctacagc ttcattgttc gcaacaatca 2838781 ctggcgccag caaaacggaa tggtctttct cagatatcga attgacttac cgtccaaaca 2838841 cgcttctcag ccttggcgtt atggagttta cattgccaag cggatttact gcaaacacga 2838901 aagacacatt gaacggaaat gccttgcgta caacacagat cctcaataac gggaaaacag 2838961 taagagttcc tttggcactt gatttgttag gagctggcga attcaaatta aaactgaata 2839021 acaaaacact tcctgccgct ggtacatata ctttccgtgc ggagaataaa tcattaagca 2839081 tcggaaataa attttacgca gaagccagca ttgacgtggc taagcgcagc actcctccga 2839141 ctcagccttg cggttgcaac taatgtaaaa gaccggttaa cgccggtctt ttttgcgttt 2839201 taccctcccc tttttctcta atccccgtta tcttttttct ggtttaaaat ttaaattgac 2839261 aaacactaga aacaggagta aattcttgag tgttcaattt catacagtct cttttaccgc 2839321 ttaatcaaac acgaacgggg gaaccaacga ttggctgttt tattaacagc cttggggtga 2839381 atcttactaa gtaagagggg gtactctgaa tccctaatcc gacagctaac ctcgtaggcg 2839441 tatacagaga ggaggtctat tatcggccat tctttgcaat ggtctttttt gtttcaaaaa 2839501 cgttaattca ctaagggaga tatgaacatt gggaagaatt aaaaataagc aatttgccgt 2839561 gatcgggctg ggccggtttg gcggcagcat ttgtaaagaa cttcatagaa tggggcatga 2839621 ggtccttgcg gttgatatca acgaagaaaa ggtcaatgca tatgcttctt acgccactca 2839681 tgcggtaatt gccaacgcca ccgaagaaaa cgaattgctt tcattaggaa tacgcaattt 2839741 tgaatatgtg attgttgcca tcggagcaaa tattcaagcg agtacgctga ccaccctatt 2839801 attaaaggag cttgatattc caaatatttg ggtgaaggct caaaactatt atcatcacaa 2839861 ggtgcttgaa aaaataggcg ctgaccgcat tattcatcct gaaaaagata tgggggttaa 2839921 aatcgcacaa agcctttcag acgaaaatgt tttgaattac attgatctat ctgatgaata 2839981 cagtattgtc gagctgctgg ctacgcgcaa gcttgattca aaatcgatta ttgacctgaa 2840041 tgtaagagca aagtacggct gcacgatcct ggccattaaa catcatggag atatctgtct 2840101 ttcccccgcg cctgaagaca tcattcgcga gcaagattgc ctggtgatca tgggccacaa 2840161 aaaggatatt aaacgttttg aaaacgaagg gatgtagaca aaggtgacac ttcaaaagga 2840221 taaagtgatc aaatgggttc ggtttacacc gcctcaagtg cttgccattg gttttttcct 2840281 taccattatc atcggggctg tcctattaat gcttccgatt tccactacga agccattgtc 2840341 atggatagat gcccttttta ctgcggcttc cgctacaact gttacagggc ttgctgttgt 2840401 cgataccggc actcaattta cggtattcgg gcaaacagta attatggggc tgattcagat 2840461 tggcgggctt ggatttatga catttgcggt cttgatcgtc atgatattag gaaaaaaaat 2840521 cggcttaaaa gaacgaatgc tcgtccagga agccttaaac cagccgacaa tcggcggtgt 2840581 cattggcctt gtcaaagtcc tgtttctgtt ttcgatcagt attgaattga tagcagcact 2840641 cattttatcc atccggcttg tacctcaata cggctggtca tccggcttgt ttgcaagttt 2840701 gtttcacgca atatctgctt ttaacaatgc cgggttttcg ttgtggcctg ataatttgat 2840761 gagctacgtt ggcgatccta cagtgaacct cgtgattact ttcttattta ttacaggagg 2840821 gatcggattt acggttctgt ttgatgtgat gaaaaatcgg cgttttaaaa ctttttcttt 2840881 acatacaaag ctcatgctta caggaacgct gatgttgaat gcgatcgcta tgcttacggt 2840941 ctttatttta gaatacagca accccggcac gctcggccac ctgcatatag tggataaact 2841001 gtgggcctcc tattttcagg cagtgacgcc gagaaccgca gggttcaatt ctctagattt 2841061 tggaagcatg agagaaggaa caattgtatt tactttatta ttgatgttta tcggagcagg 2841121 aagcgcatca acggcgagcg gcattaagct gactacgttc atcgtgattt taacatctgt 2841181 tattgcttac ttgagaggta aaaaagaaac ggttattttc cgccgttcca tcaaatatcc 2841241 gattatcatt aaagctttag ctgtgagcgt caccagtttg ttcatcgtgt ttttagggat 2841301 tttcgccctg acgatcacag aacaagcgcc atttcttcaa attgtgtttg aaaccttttc 2841361 cgcattcgga actgtcggcc ttacgatggg gcttactcct gaactgacaa cagctggcaa 2841421 gtgtatcatc attgtcatca tgtttatcgg aagaattggt cctttaacgt tcgtgttttc 2841481 attcgcaaaa acagagcaat caaatatccg ttatcctgat ggcgaagtgt ttacagggtg 2841541 atatcaaaaa aatccggcgt gcagtcgccg gattttttat gattcgatat gagattgatt 2841601 ttgtcttttt tcctgttccg cgatgatttc gttatcctcc gcgttatcac gggtcacttt 2841661 ttgcgtaaga atcgcaccaa ctgctacaag tatcataaca gcgatgtaat aacctttttc 2841721 attgagttcc agattatcag cattatagag tccgatacta aacaaaaata ctcccgcaaa 2841781 aaaagtaaaa taagctagta ctgtaaaggc aaccgtgttt ctgcgtctat atttctgcac 2841841 ctttgttccc tcccgaaagc atagttaaaa agtgataact tccgtggaat attatacctc 2841901 aaattccccg gaatggaaca aagaattaaa aataccagta aaaagggctt aggttgcctc 2841961 ctttatttca acagctgaat catcaatcca gccgataagt ttatcattga tttggaattg 2842021 gtaccataca gactggcctt tctgtttttt agacacaacc tttatgtctt tgccgacgta 2842081 agattgggca gaggtaagcc ttatggaccg atcatcagta gaaggcttgg accatacgtc 2842141 ttgaacggca ctgtctttaa tagaggcgtt taaatccaca gatttgaggg atggatttac 2842201 ctcatcgtac tcatctaaat cgtatttttc cacaatagcg ctgattttgt cagcgtagtc 2842261 agggtctgta gcatatcctg atgtttgcag ggcggttgcc gcttccttat aattccctgc 2842321 ctcaagcacc ggtttatact tctttttatt ccacgatgtg ccacggacga acaattgggc 2842381 gtgatcatcc atagattcaa aaaacgtgct gtattttcga aacttcgcgc gaatggtttt 2842441 tcttttccct ttttcaactt cgtccgtttc catcgtgaca tgatggcctt tataattccc 2842501 ttttacgcca aaaaggttgt tggccttagc agccagttca ctgttccccc agtccgattc 2842561 gagaatggcc tgagcaattg tgatgctggg gagaacatgg tatttttcat acaaaatttg 2842621 ggcatgtccg gacagactgt ctataaatac ttgctgttca tcgatttctt cagtttcttt 2842681 ggatatttca atcggttttg ataaagttgt cgctaaaaca aacagagcta gcggaatcga 2842741 tacaaggaaa aatagtgaaa tcaagagttt acgtttttta agttttttac gggccatgaa 2842801 aaccttcctt cgaattaaaa gattacgaat gtaaaagaat ctacctttta gaattttact 2842861 tgcacttcta atatttttca attctttagg gataaagttg ggaaaagatt gcaaaataaa 2842921 aaccttttcg ctcaatgaaa aggtttttac catgtttcta tttttgtaaa tttctgagtg 2842981 cattccgata ttccgtatca tttattactt tatatgattt gacagttgcc ttcgacaaac 2843041 cttgtgctga gacggccggt ttttccggag ctgttttcgc tttatcatgt ggtttatgtg 2843101 ccagcttgtg ccccattcca gtggcattca tacaaaatga caggcagacg agcagcacgc 2843161 taaggataaa agaaatgaag aagagatcat gataagcagt catcatagaa tcctgtaccg 2843221 aaccgctttg tctggcagca tcttttttcg tgaaaaagcc gatgagaatg ggaactccca 2843281 tatagacaaa caatcttaaa aactgaacag ctgtcattct cttgaccaaa tcaggcagcg 2843341 ggcctcccat ggcagctccc atcagccctg cggcgactgt caggcctgtt cccgctgcaa 2843401 gcatgataaa cagtgccgcg aacatataaa gagatgatcg atcctgtata tgcagccatt 2843461 gaaaattcac aaaaacgaga atgagtccgc cgataatacc gagcatccct ggtccgactt 2843521 tatcgtataa cagagcgctc aaaatggccg cgatcgccac tccgattaaa agagtcaagc 2843581 ttaaaagaat gagatgctcc tgagaaatat catacatttg acggagcaag ccttgaaaag 2843641 cagaaaggct gacagctacc gttatcgtcc ctgcagctat gatcaataag ccgagcaccg 2843701 gttttggcag cagcatcagt ttaatagata tgaaggggtt tttcacttta tattccacaa 2843761 tcaatagacc aatgagcaaa cataacgtca ccccgaaacc aatccataca taacccgatg 2843821 acagccccca tttttgcaga aaaatgaatg aaaccgctga ggctgcggca aggaagacag 2843881 ataaaagaat tcccgcacga tcaagcggct gttcttgatc cgccgctccg tgatgctcat 2843941 catgaagaaa gaaatagctc accgcgacac cgatcaggga caaggtgcca aagatgaaaa 2844001 acagccatct ccaatgcccg cagcttgttg caatggttcc caggattgta ccgatgataa 2844061 cagaaccata gaatcccccg atcagcacaa gcagtgcata gttcctgcgt tcaatcggga 2844121 atgacagtac aagcattgga atcataatca tcagcatgac gcctgttgcc gccccttgta 2844181 aaaagcgccc tgccgccatc aatgcaatat cgcctgaaca tgcgatgagc agtgagccta 2844241 gtataaagac aggtaatgaa gccagataga cgggacgagc accgaatttt ttcctcagca 2844301 gcggtcctgc cggaactaac aaggcaaagg ccatattgcc gatcaatatc ggatttactg 2844361 atgtaaagac acttgttcca accgttttct gaacaaggcc ttgaactgac gacaatgccg 2844421 tgttagacat caatcccggc ccgaccgcta agacggcgag caaagaaatc acccaatagt 2844481 gttttgtctt catgttgtca tcccttccta tatgaataca tgcgaaacac atcatttttt 2844541 gaaaacaaaa gaagctaata gattttgcat accattagct ttcattctaa tattctccct 2844601 ttcaggggaa atgatattat tttattataa ttatgtgaat gaatgagcat ataatcaaat 2844661 attatttcaa atcgattgtg ttttgtcaat ggagtaaatt tcaagcacaa catagaaagc 2844721 ttgaaagctt ttccccgata ttgtgtctag aactgcactt atgaatccct gctcgttccc 2844781 tcaagcgaat taaagcaggc cgttttaatc ctttcaatcc actattccaa ctaataaact 2844841 caaataagtt ggtgataaga caacatttta cccccacatt tttttgtgtt cactgggcgt 2844901 ttgccgcctc taaattgtat atgggtaaat accatgaatt aacctatgaa ataccaatgt 2844961 aagggaggca aaaacgaatg gaactgtatg agtgtatcca agacattttt ggcggcttga 2845021 aaaatccatc ggttaaagat ttagcaacgt ctttaaaaca aattccaaac gcagcaaaat 2845081 tgagtcaacc gtatattaag gaaccagacc agtacgctta cggccgaaat gccatctatc 2845141 gaaataatga attggaaatt atcgtgatta acattccgcc aaacaaggag acaacagtac 2845201 acgatcatgg tcaatccatt ggttgtgcaa tggtgttaga aggaaagctt cttaattcta 2845261 tttatcgttc aaccggcgaa cacgcagaac tctccaattc atactttgtc cacgaaggag 2845321 aatgccttat ttcaaccaaa ggtttaattc acaaaatgtc caatccaaca tctgaacgaa 2845381 tggtgtctct tcatgtctac tcccctcctt tggaagacat gacggtcttt gaggaacaaa 2845441 aggaggtatt ggaaaattca tgattgacag ataaactgct cactttgact tcactcaact 2845501 ggaggattca gagaatgaaa ccttttcctc aaaacaaaaa aacccttatc gaataagggt 2845561 ttaaaggtat ggagccaagg gggctcgaac ccctgacctc tacgctgcca gcgtagcgct 2845621 ctcccagctg agctatggcc ccgtatgtaa cgtcatgttt attatagatg attttatttt 2845681 gaaaaacaag ctgtttcctc ttgaattgac agaaaaaata aggctcggaa aagagcctta 2845741 tttttcgact tacatcatga tcaaaagtaa aatcacaccg agaataattc gatagattgc 2845801 aaatgggaca agtttgattt tgttaatcag ccttaagaag aaacggacga caaacagtgc 2845861 gaccacaaag gcacagataa agccgacgat gaaaaacggc atcagatccg aacttaagct 2845921 gtcccaatgc ttcacgaggc ttagaaagct ggctcccatc atgatcggca tcgccataat 2845981 aaacgtaaag tcggctgcag ctcggtggtt taatccgaga ataacaccgc cggaaatggt 2846041 tgaacccgaa cgcgagaaac caggccaaag ggaaagacat tggaataagc cgacggctat 2846101 cgcctgttta taggaaatgc ggtcgagtgt gtctgtcgct gttttccgtt tattgaccca 2846161 gtcagcaaaa agcatgagga ttgccccggc aattaaaccg atggccacag ttttaacgga 2846221 aaataaatat tcatcaatgt aatcttcaaa caaaaagccg agaacagctg caggcacgag 2846281 tccgacggca atttgggcaa tgcttaattt atgtccctgc tcctggtcgc ttgtaatatt 2846341 ttttttcaag cccagtaaat ttaaaattcg gtctttaaac acgatagcta ctgctaaaat 2846401 ggagcctagc tgaataacca ccttgaatga gttagcagct tcttctgaca tcagattact 2846461 tgattttagc cagatgtcgt ctactatgat catatgtcct gtcgaagaaa ccggcgcgta 2846521 ctctgttaat ccttctacga ttcctaaaat ggcggctaca aacaattccc atagagtcat 2846581 gattttgatt ctccccatta gacatttatt tttttacata acgggagctt cccataaatg 2846641 gaaagcccgt cttatataac tataaacgaa aatcacactt tatgccccgg cgtattttca 2846701 tttttttctt catcgtataa atgtgactgc attttaaacc agtcaaataa atgtgtcgta 2846761 atgactttgg caaccgcata gccgggaatc gcaagaatga ttccaacaac gccaaacagc 2846821 ttgccggctg ttaacagcag aaaaataatc gtaatcggat ggatgtgaag gttttttccc 2846881 ataatttgcg gagagatcag cttcccttca atcagctgaa caatcgtcca aacgatcacc 2846941 agcttaagca gcatgagcgg cgatgtcact atggcaatga taatcgcagg cgtaatggca 2847001 atcgttggcc ctaaatatgg aacgatgctt gtgcaagccg caatgactgc aagcaatgaa 2847061 gcataatcca gcccgataat caaataaccg ataaacagca aaaacccgat acagaagctg 2847121 acaatgatct ggcctctgat ataagagctt aaccgatgat tcatttcgct taagactgta 2847181 tatgtctgtt ctttcaatcg agtcggcaca aacttcagta tgtagaccgg taattttctt 2847241 ccgtctttta gcaaataaaa tagaataaac ggaaccgtga cgatcgaaat gataatctca 2847301 gtcagtgcgc cgataaaatt cccaacaccg gtaaaggtgc tgttcacgat cgtcgctgcc 2847361 tgatccgaaa cctttgtagc aagatcagat atattaatgt tcatcgtttg ctgggcctga 2847421 ttgacgaagt tgctgccaat cagctgtttc gtctgatttt ctacgacgtc cacatatctc 2847481 gggatattgt caatcaaact cataatttgt tcttttaaga agggaatgat cgacacgatc 2847541 gtgatcgtga tcagcccgat aaccaatagg tatagcagca atatagaata gattcttctt 2847601 attcttcttc tctccagaaa atcgacgact gggtttaaca gataaaaaac aatgcctgtc 2847661 aaaataatcg gaagtgatat cgttttgagc agaacaataa tcggggtgaa aataaatgat 2847721 gtttttgtaa atactagaat atttaaacca atcagcagca gcacaagcaa aaataaaaca 2847781 aacttattat ccaagaagaa tcgcttgaat ctgccgctcc atgtttgcaa cgtctccact 2847841 atcgttcctc cgtcatacat agtttaatta aattgtacac tatcgtccct ataatgaaaa 2847901 ataaaaaccg ttaattgctg gaaaagcttt ctcggtttta acattctatt tatatctatc 2847961 atgtgatttt gttcttttta agctataatt tagctatatc atgcaaaagg agcgatacga 2848021 gtgatacgtt ttgcaataat aggaaccaac tggattacag accgctttct tgagtcagca 2848081 gcggatatcg aagattttca gctgactgct gtttattcaa gatcggctga acgcgctggc 2848141 gagtttgctg ctaaacacaa cgctgcgcat gccttctcag accttcagga aatggcggcg 2848201 agcgattgct ttgatgccgt atacatagcg agcccgaacg ctcttcacaa ggaacaagcc 2848261 gttctcttta tgaaccatgg caagcatgtg ctttgtgaga agccgtttgc ttcgaataca 2848321 aaagaaacag aagagatgat ctcagcggct aaggcaaacg gcgttgttct catggaagca 2848381 atgaagacca ctttcctgcc gaatttcaaa gaactgaaaa aacacctgca taaaatcggc 2848441 actgtccgca gatttaccgc aagctactgc cagtattcct cacgatatga cgcgttcaga 2848501 agcggaactg ttttgaatgc gtttcagcct gagctttcca atgggtcatt aatggatatt 2848561 ggcgtctatt gtatttatcc ggctgttgtg ttgtttggcg cgccgaagga tgtaaaagca 2848621 aacggatatg ctttatcctc cggagtggac ggagaaggaa ctgtcattct gtcttacgac 2848681 gggttcgaag ctgttctgat gcattccaaa atctctactt cctatgcccc ggctgaaatc 2848741 cagggtgaag acgggacgat tgtaatcgat acgattcacc ggcctgaacg tgttgaaatc 2848801 cgctaccggg acggccgcct tgaaaacatc gcgatccctg atcctaaacc ggcgatgttc 2848861 tatgaagcag aagaatttgt cacgcttata aaagagaata agctggaatc tgaagaaaat 2848921 acatttgaac ggtctttgac caccgcaaaa attatggaag aagcaagaaa gcaaatgggg 2848981 attgtatacc ctgctgatca agcttaaaaa aatccgcccg cgtgcaaatg ccgcggcgga 2849041 ttttttatta gacaatcgga gaagatgcct tcctttttaa aagcacctgt tgctcatatt 2849101 ctttgatgtc ataaagccat gcctctttta ccggaacgcc catttgctca cagtaggaat 2849161 cccagatggc tccgaaagga tatgttttga attcctccat cagggccagc ctttctgtat 2849221 agcggccctc ttcctgcaat tgttttaaat atccgttcgg gagaagcagg gcatacaata 2849281 aagctttgat catatttctc gttccgatgg tccaggcggc tacacggtta atgctggcat 2849341 cgaaaaaatc cagaccgatg gctaccttct caagagcatg atttcgtaca atttcaagag 2849401 cgatttctct caattcatca tccaaaacca ctacatggtc gctatcccaa cgaacaggcc 2849461 gcgatacgtg caaggcaagc ttgtctgtgt aaagcagcat ggacgagatc ttgtttgata 2849521 ccgtctcagt cggatggaaa tggcctgtat caagtaaaca aagcttatga ttcgtcaaag 2849581 cataagctaa ataaaattca tgagatccga caacatatga ttcggagcca agcccgaaca 2849641 gcttgctctc gattgaatca agattatgtt gttcactgat ctcctctgag aagatccgat 2849701 ccagtgattc ttttagtctt ttacgcggtg tcagcctatc actcgggata tccttatagc 2849761 cgtcgggaat ccaaatattc gtcaagcaag gtgttcctaa ttctttcccg aagtattccc 2849821 cgatacggcg gcaagcgatg caatgcctga tccaaaattc tctgatgtcc ggatcagggt 2849881 gtgaaagggt gagtccgtca gccgctttct catgcgaaaa caaggttgga ttaaaatcta 2849941 aaccgagacc aaggtttttt gcccatttca cccagttttc aaaatgctgc ggcttcaatt 2850001 cgtcacgttc taccgcttcc ctgtttgttt ctgcgtatat cgcatgcagg tttacgcggt 2850061 gctttccagg aatgagagaa agagccttct ccaaatctct tcttaattct tcaggagttt 2850121 gcgcttttcc gggataattg ccggtcacgt caattccgcc tgaaagctcg cccttattta 2850181 cttcaaagcc ttcaatgtcg tcaccctgcc agcagtggat cgaaatgggc acttgctcta 2850241 attgccgaag cgcctcttca acatcaattc cccatttttc atatgcctgt tttgcactgt 2850301 cataattggc ttttatggtc atacggctct ctccctttat cagtttttca atccaaataa 2850361 aaaacttcct ttagatctat cgcaacagga ctgaaatccg aatttgtttt cattaatggc 2850421 gccatcgatt tccaccatct ttggcaaact tccgtgtccg ccatctttct ccatttctct 2850481 tcatcctcta tttctaaata tgcaaaaagc ctgcctgttt cctcgtctag aaaaatggaa 2850541 taatggtgtg ctccatgagc tttgagtgct tctgccatct caggccaaat gtcatcatgc 2850601 cgctgtttgt attcttcgta cttgtcttga tggacaaaca tgatactggc ttttcttttc 2850661 aaaccttttc acctcttcat catttagata gcgctttcaa aacagtttgc tgaaatgact 2850721 gaatgatcgt gcttctatca atgtctttag gtgtaaacac tttgatcgga aaggaatttc 2850781 tgacgacttg ccgggcttct tttatgtctt tgacttcttt ggcagcaatc atttgcatca 2850841 aaagatttcc ggtggcagtt gcctctatcg gccctgcata taccgctttt ccactcatgt 2850901 ctgccgttaa ttgatttaag aaatcattcc gggctccgcc gccgatgata tgaaattgct 2850961 cgatcggttt ttctgtgatt gtttcgagct ctttgatggc tatcgcatag atgatggcta 2851021 aattgctgta gatgcagcag gcaagttcgc ctgcagtacg gggaatcttt tggcgggttt 2851081 gtctgcaata atgttgtatt tcctttatca tgttttctgg attcaggaaa cgtttatcat 2851141 ttaagtttat aaattgctgg aatggttctg tttttttggc ttcttctgca agctgctgaa 2851201 aagaataatc tgcttgtagc tgctgtttga cttcttgtat cacccacatg ccgataatgt 2851261 ttttgagaaa gcgaatggtg ttgtttgcgc cgcgttcatt tgtatagttg ttttctaaag 2851321 caagatcagt tattatcggt gttttgtttt caaccccgat taacgaccat gttccgctgc 2851381 tgatatacgc ccagccatca tttacgcctg gcgccgcaat gacggccgag gccgtatcat 2851441 gtgttgcgac tgtcatcacc ttgcacgccg ggagatcata atccgggaac cactcatttc 2851501 ttagcttccc gagttcacac cccggttcag tgagcggcgc aaattgctgt tccagaacag 2851561 acacggcttc aagcaattca ggatcaagat ttcccgttga gacgtttaaa agctgtgttg 2851621 tggacacgtt tgtgatttcc gttacagctt ttccggttaa acaatagcct aaataatcag 2851681 gaatcatcat aattttgtct gtctttttca gcagctcacg gtcttcttca aacaattgat 2851741 agatcgtgtt gaaaggctga aattgtattc ctgttttttg ataaattgcg gcttttgaga 2851801 gggtatgttc cagtttgtct attgtgtgat ctgttcttct atcacggtag gagattgctt 2851861 cccgcaaccg atcgcctttt tcgtccagta agacataatc gactgcccat gtatcaatgc 2851921 ctacggtgca gtgttcatac ccaagcgtct ttactttttg cagtccttgc aggatttgtt 2851981 ttagcaaatg atcaatatcc cataagcaat gcccgtctct ttgactgaaa ccgttagcga 2852041 acctgtgaat ctcttgtatg tcaagcttcc cttcattcag ttcacctacc atgattctcc 2852101 cgcttgatgc gcctacatca atggcagtat aaatcatcct ttcaccctct cttcgaaaga 2852161 ggaacagctg tcaccttcac ctttttgtcc tcaagagctt ttaccgatgc cggatcaagt 2852221 ccagaatccg taataaggcg gctgacatct tgcagcgagg cgatatgtga aaactcgcgg 2852281 ttcccccatt tgcttgaatc ggccatcaaa atggtctggt ccgacctttc gatcatccgt 2852341 tttttgagca gcgcctgcca ctcatttgaa tcactcatcc cgttgtgtac gtcaaatccc 2852401 ttacatgaca gaaaggtttt attgacatga taggtctcaa gtgaacgctc tgctaacggg 2852461 ccggcaaatg ataatgattt ttccagcaaa atgccgcctg ttgaaatgac tgatatgttt 2852521 tctttattgc tgagttcaat agctgctttc attgagtttg taatcacggt gagctcaatg 2852581 tcagggagta tttttgccat gtaccaagcg gttgtgcttg catcgagaat gattcggtct 2852641 ccgcttttta catatttggc cgcttcgtga gcgatggctt ttttttcgat gacattcgtg 2852701 atttcccgtt cagaaaaatg aatttctgat tccttctgct gaatactgac cgctcctccg 2852761 tggctccggc tcagtttatg ttctttttca agcttttcaa gatcacgccg aatggtttcc 2852821 tctgtgactg aaaaaatgtc acttaattcg gaaacgcgga tgcttgaacg catatttact 2852881 atttccacta ttttttgctg ccgttctgct actagcatcg gtaacgccct tcctcatatc 2852941 gtagtccgtc ttatattttt atcatagcat atatctaacg cgtaaaagca gcagggacgc 2853001 cgccgtctac cgtgatcatg cagcccgttg ttttttcggc tttggaagaa gcgaagaatg 2853061 caatggcttc ggcaatatcc tccgggtaaa tattgacgag caatgctgtc cgtttccggt 2853121 aatgttcctc cagctgatcc ggttcaatcc cgtacgccgc ggctcgttcc tcacgccagc 2853181 ttgaacccca gattgccgat ccttgaagaa ctgcatcagg caaaacggag ttgaccctaa 2853241 tgccgaattc tccgccttct gctgcgatgc atcttgctaa atgggtttca agcgccttaa 2853301 cagagctgta ggcagaggcg ttttttcccg cataaactga atttttcgat ccgacaaata 2853361 ccatgcttcc gcctctattt tgatgtttca tctgtttaaa cgcttcacgg gctacaagga 2853421 aatagcctgt tcctaaaaca ttcatattaa gattccattc ttttagactt gtttcgtcaa 2853481 atgggcttga tgtggccagc ccggcattat tgacgacgat atcaatgccg ccgtaagcaa 2853541 gcgccgctcg ttcaaaagct gactgtacgt cttcctcctt tgtcacatcc attttgacag 2853601 ccattgcccg tccttttccg tatgcatcgt ttatttcccc ggcaattttc tgtgcgcctt 2853661 ctatattcag atcagctacg atcacgtgcc ctccctcagc tgcaaatcgg cggcatgccg 2853721 cactgccgat tccgccggct cctccagtta tcagcgctac ttttcgggaa aattctgctt 2853781 ccggcggggc cagcgtgagt ttatatagtt cgagcggcca atattcgaca tggtaggact 2853841 cattttcatg taaagaaaca aattgcccca gagcggttgc tcctttcatt acggcgatgg 2853901 ccctccgata taaagccccg cttactttag acatcgcata actttttcct gtattcacca 2853961 ttccgattcc aggaatcaat atcacccgcg gggcggattc aaagatttga tccccatcct 2854021 gctgattgcg tgtaaagtaa gcctgatact ctgatgtaaa ggtctcgact cctgacttga 2854081 tcagatctgc aagcttgtgc acatcttgag tttccggatt ccaatcaatg tacagcggaa 2854141 cccgttttgt gtgaacaagg tgatccgggc atgccgcacc gatttgcgaa agtgctggcg 2854201 cttggacact gtttacaaat tccaagacat cgtcatgatc atcataggaa aggatcattt 2854261 tcttttcttc acttactgct cctctgatca caggcatgat gcctgccaag atttgttttc 2854321 ttttatcctc cggcagcggc tgataccttt tgcctccgaa tacctcatgc tgattgatac 2854381 gatcgttaat atactgctcg gcttcttgaa tgatggatat cgttttttga taacatgttt 2854441 cagacgtctc tccccaagtg actaagccgt gtttctccat taatacaagc tcggcgtggg 2854501 ggttgtttgc tacgccttca gcgatcattt tagacaaagt aaatccagga cggacgtatg 2854561 gcacccatac aaaccgattt ccgtaaatgt cttcagcgat ttgttttcca ttatccgcac 2854621 agcatatgct gataatcgca tctggatggg tatggtcaac atgtttgtat ggcagaaaag 2854681 cgtgtaatag cgtttcaatt gaagggcggg gatgtttgct gtctatcata caatgagaca 2854741 ggtagtctac catttcttca tcgggcattt ggtccctttt aatcagcggg cggatatcat 2854801 ctaatttcaa accggaaaag ttatgcgctt tcattgttgc caaatccgat ccgcttcctt 2854861 ttacccacat gacttctatt tcacggcctc taaaatcctt ttccgttgtt ttcatagatg 2854921 tattcccccc gccccagttg cagacagtgc ggtctgaccc gatcagattg gacctgtaca 2854981 ccaattcctc tacaccttta ggtagctgtg cagctcgctc tgaatcccat atatgtttca 2855041 ccatatttga tattcctcca taccctttta tttgtatccg ttttcattat atatgatttc 2855101 tgtttgtttt tgaatcgttt ttgtttattt ttgcttttta acaaaaaaag aaagcagcag 2855161 atatgccgct ttctcgtttc attatgattc tattttaaat ttcttcgtaa tgtcctgaag 2855221 ttcttccgcc atgtttgcca acgtttccgc tgaagagctg atttcttcca tggacgcaag 2855281 ctgttcttcc gccgaagctg cgatatcctg aatgcctgct gagctttctt tcgccactgc 2855341 agaaatatct tcaacagcac ttgacacttc ctgtgatccg gctgacagtt gttcaaccgt 2855401 cgcgttcaag ttttgcaatt cgccggaaat ttgggttgtc atctcataga tttgtttaaa 2855461 gctttccgct gtttgatccg taatctgcaa gccttctttc acttcatgat tcacggattg 2855521 gaacattgaa agtgaggtgc tgatttccct gacaatctct tgaattaatc cttcaatttc 2855581 cttggcggag tctgctgatt gtacagcaag ttttctaacc tcttccgcaa ctactgagaa 2855641 acctcttccg tattctcccg ctcttgccgc ctcaatcgca gcatttaatg caagcaggtt 2855701 ggtttgatca gcaatgccgt taatcacatt caagatgctt gtgatgtctt gcgattttgt 2855761 ttcaaggccc ttcacaaccg cttccgcttt ttgaacggat tggtcaattg ttttcatctg 2855821 gccgactgta tgctccacca gcttttctcc gctgcccgct gcctcagagg actgaatcga 2855881 tgatttcgta atggttgaag aggcttgagc cacttttgaa atcccctcgt tcatttgaga 2855941 aagatgattt gagcttgttt ccagtttctc gctttgtgcc tcgttgccat ctgagaactg 2856001 ttcgatggca agtgtaatat gttcagttgc cttgcttgtt tgggctgcgc ttgctgtcag 2856061 ctcctcagaa gatgaagcga cgttttctac agacgtttga ataacgccta ttacagaacg 2856121 caatgatgca gacatttcat taaagctttc gccaagctgg ccaaactcgt ttttcgagtg 2856181 aatgtcaatg acttctgtga gatctccgct gctgattttt gcagacgttg agacaagttt 2856241 tcttaacggc ttggtgatgg cacggataat atagagtatg agtatgccgc cgattactat 2856301 tgacacgcat agaatgataa ccgcagtgtt cagcaccggg cttgaagcat cttgcaattc 2856361 actgacaaaa tatgtgcccg cgattttcca gccagtcagt ttatttgtcg taaaggccat 2856421 tttcttttct ttgccttcga atgtatattc aaatgagcct tcttttttgg aatatacttg 2856481 gtttgtccaa tcgccggaac cggttgtccc cggcttaatg gtcggatggg cgatatattt 2856541 tttgttgcct gtcgtaataa atgcaaagcc ttcttttccg attttgattc tttttgatgc 2856601 agtaagcact tcatccaggt ttaaatctag cgctataacc cctgaaccgt cttttaattg 2856661 ttttgaaatt gtgacaacga tatctcctgt cgcttcatcg gtatacggtt ctgagaaaac 2856721 agcttgtcct ttttccgcaa ccgcctgttt gtaccagtca cgtcctgtcg gatcgaaacc 2856781 tttcggaaca ccgctatccg gatatttata aagcttctta tcttctgagg cagcatagat 2856841 tgcgcctaca tcgtcgttaa gtgtcgtgta ctgcttaaat ttctctttca gtaatgtttt 2856901 gtttttgcct aacaatatgt ctttatcgac tgtctcacta taataatcta ttgcttttac 2856961 tttatcttct aatttatttt gcagcgtact gtttagttct tcaacatttc ccttcgcact 2857021 gcttatgagc tctctgtcta acgcgttcca agctgattga taactgaaat atgctaaaac 2857081 cccaaccggc aaaataagca ctgccagaaa cgcagcgatt agcggtttgc tgatcgatgg 2857141 ctgtttgatc cattgtatga attttcccat tctcgttgac tcctccttta agataaatct 2857201 aatatcgtca aactaggata aaaggtttaa taaaaaaact aaaaaaaaca cccaagcgca 2857261 acaagcttgg gtgttaaggc ttattattca attttaaatc gtttggtcat atcccgaagc 2857321 tcttccgcca tagaggaaag ggtctctgca gacgagctga tttcttccat ggaagctagc 2857381 tgctcttcag ctgacgccgc gatatcttgt atatgcgctg agctttcttt tgaaatcgat 2857441 gcaatgtgct cagacgctcc cgaaacttct tcggagctgg cagaaagctg ctgaaccgtc 2857501 gcactcatat tttgcagttc gccggcgatt tggttcgtca tttcagaaat gcgtttgaag 2857561 ctcatttctg ttttatctgt gatgtcaagt cctgtctgca cctcttgatt gacagattgg 2857621 aacatgccga gtgatgtatt gatttccttc acaatttcga tgattaatcc ttcaatctct 2857681 tttgctgaat ctgctgactg tactgccagt tttcttactt cttccgctac aacggagaag 2857741 ccgcggccgt actcgcctgc gcgcgctgct tcaattgctg cgtttaaggc aagcaggttc 2857801 gtctggtctg cgatgccgtt gatcacacgc aaaatgtttg taatatcttt cgatttcgtt 2857861 tccaatccgc gtacgacttg ctccgcttct ttaacggact tgtcaatgac attcatttgg 2857921 ccgacggttt gatgaacaag cttgccgcct tcacttgcaa tttctgtcga ttgaacagat 2857981 gaatcagtga tcacttcaga agcttgagcc atattcgtca acccgtcatt catttgataa 2858041 atgtgctctg ctgccgtttc aatgttttcg ttttgttttt cattgccgtt agaaaattgt 2858101 tcaatcgcca atgtaatgtg ctctgttgcc ttgctcgttt gcgcagctga tgcagtcagc 2858161 tcctcagagg aagcggcaac attgtctacc gaatcctgga tggcgtgtat gagagaacga 2858221 agtgacgacg ccatattgtt aaagcttttg ccgagctcgc ccaattcatc ttttgaacgg 2858281 atatcaatgg tttccgtcaa atctccctcg ctgatccgct tagaggaacc gacaagctgt 2858341 ttcagcggtg ttgtaatcga ccgaatgatc aatgtcatga cgataatccc tatgataata 2858401 gctgcggcca agacaattaa agcaaggtga aggacaggct gggctgcctc atggatttca 2858461 tccaaataca tggtgccgcc gatcttccat cccgtcaact tgtttgtgtc aaaggccatt 2858521 tttttcttat cgccatccat ggtgtattga aaatcgcctt tatcagcact caacatctta 2858581 tcgagccagt cgccttttaa ttcagttcct gattgttcat tagggtgtgc gacaactttt 2858641 ttgtccttcg tcatgataaa tgcgtagcct tgtgtgccga tgttgacttt tttggttgtt 2858701 ttcagcagat tttcaatcgt catgttgatt gcgataacgc ctgaaccatc ttttgtctgc 2858761 tgggcgattg tcacaaccat cgtatttgtc gacgcggttt tataagggtc tgtgatcacg 2858821 actttccctt tatttgcaac cgcttttttg taccagtcgc gttcaaccgg attatagccg 2858881 cttggcatcg gaagatccgg atagcgggta aagtgccctt ttgtgtcact tgtataaatg 2858941 gattctacat ccttgttaat gctgatatat tgtgagaatt tctctgcaat gcttgcattg 2859001 ctttttgcat tgtatttctc ttttgtcagc cattcgctga aataatcagc actgttttct 2859061 ttttcgccga tgctggtgtt aatgatttcg tttaattgct gtacattttc caatgcgctc 2859121 cccatcatct gtctgtcgag tgagctgcta gccgattgat acgcaaagat cgccaatatg 2859181 acaaccggta tgatgaggat cgacagaaag gaaacgagaa gcttccgtgt aattgatctt 2859241 tgttttatga gttggagtat ttttttcatc attcatttct ccttttttat gctacccttc 2859301 atatcggctg gaaatgggta aatatataca gcaaaaaaga agaaatttaa caaaagtaac 2859361 taatttccca taaataaata gtattttaga cctattattt gtctacttta aattgttttg 2859421 tcagatcacg gagttcttca gacattcttt caagcgtcag tgcagatgaa ctaatctcct 2859481 ccatggatgc cagctgttcc tcagctgaag cggcgatatc ttggatgcca tccgagcttt 2859541 ccttagaaat ggcagtgata tcatttgaag ctgcggaaat ttcttgagct cccgctgaca 2859601 gctcctcaac cgtcgcattc atgttttgca gctcggaagc aatttgattg gtcatttgcg 2859661 atatatgttt gaagctctgt ttagtttcat ccgtcatgac aagccctgtt tcaacttctt 2859721 tgtttacgga ctgaagcacg ttcagtgatg tgtgaatttc ttttactatt tcactgatca 2859781 gcgattcaat ttcttttgct gagtcagccg actgtaccgc gagctttctc acttcctcag 2859841 cgacgactga gaagccccgg ccgtattcac ccgctctggc agcttcaatg gcggcattta 2859901 aagccaaaag attggtttga tccgcaatgc cgttgatgac acgcaaaata ttcgtgatat 2859961 cctttgattt gatctccagc cctttcacca cttgttccgc tgcttttacg gaatggtcaa 2860021 ttgtgttcat ttggccggct gttttctgga cgagtgtctc ccctttgctt gacacttcgg 2860081 ttgaatctgc ggatgtttct gtaatcactg ctgcagcccg cgccagctct gccaatccgt 2860141 cattcatttc attaatttgt tcggttgtcg tttctatttt ctcgctttgg ctttcactgc 2860201 cgtttgaaaa ttgctcgata gccatcgtaa tgtgctcagt ggctctgctt gtctggtctg 2860261 ccgatgcagt cagctcttca gacgaggagg caacgtgttc tactgagtct ttgatcccgt 2860321 gaatgagcga gcgaagcgag tgtgccatat gattgaagct ctcactcaga acgccgagtt 2860381 catcttttga attgatttca atcgtttcgg ttagatcgcc ttcactaatt ttttcagcgg 2860441 atgcgacaat gcgtctcaat ggctttgtga tggatcgaat cacaaaataa atcgccgtca 2860501 ttccagctcc gatggcaatc gccagaacga ttgaagccat gatcagaacc ctgcttgcag 2860561 catcgtgaat ctcgtttgca tacatcgtgc cgctgatttt ccagcctgtt gtttggcttg 2860621 ttgcaaatgc catttttttc tttttgcctt tgtacgtata ttcaaagtcc ccgcttttat 2860681 ccttgtagag cttatcaacc cagtcccctt ttagctctgt tcccgctttt tctccggagt 2860741 aggcgatgac tttcttgttt tggctcaaaa taaaagcata gccttctttt ccgatattga 2860801 ttcctttcgc ggtagtgact aagtcatcaa ttttcatatc aatggcgaca acgcctgacc 2860861 catccaccgt ttgacgggcg atggtgacga ccatttttcc tgatgaaatc gattcataag 2860921 gctcagtgac aattgttttg cctttattgg ccattgcttc tttgtaccaa tctcgttcca 2860981 aagcattaaa gtcgcttggc atgtcagcgt acggataacg tgtgaagtcc ccgtctttgc 2861041 cgcttgaaaa taccgcagcg acattatcat tcatttggat aaattgttta aattcctgtt 2861101 tcagctctgt tttcttttta tcctgaaatt tttctgctgt agcccaatcg ctgaaatatg 2861161 cgaggctttt ttcagtagtg ctgattttat catcaatgat gtgatctaat atctgaacat 2861221 tttcctttgc gctttgcgtc atctgtacat caagtgaggc aactgctgat tgataagcgc 2861281 taaccgaaag ggcggttatc ggaacaatta agatcagcag gaaagaaata ataagtctcc 2861341 ttgcaattga tgatctgcga atagtggtga gtgttttttt catttccttt tgaaccttct 2861401 ttcaataatt tacaaattat atcggcggat cttcctttaa attacattga aaatggagga 2861461 aaaaatgaaa aatagttcta aattcacctg ttaaactagg actttattat tgtttaccat 2861521 ataaaaaaac agcgctttga tagcgctgtt tttcggtttt tactcgattt taaattgttt 2861581 cgtcagatcg cgaagctctt ctgccatctg cgcaagagtc gtcgctgagg aactgatttc 2861641 ttccatggaa gcaagctgtt cttcagctga tgcggcaatg tcctggatgc ttgccgagct 2861701 ttctttcgac acgtctgcaa tgccgctgac tgctgctgaa acatgctgtg aacggtctga 2861761 cagctgctcg acggtggaat tcatcgtctg cagcttgccc gcgatttcgt ttgtcatgct 2861821 gaaaatgctc tggaagcttt cttttgtatt gtctgtgaca acaagtccgg actgtacttc 2861881 ctgattgacc tctttaaaca tgtgaagaga ggtgtcgatt tctgcgacga tttcttggat 2861941 cagcttttcg atttctttcg ctgaatcggc tgattggaca gccagcttgc gcacctcctc 2862001 cgctacgaca gagaagccgc gtcctgactc tccggcacgc gccgcttcaa tggctgcatt 2862061 tagtgcaagc agatttgttt ggtcagcgat tccgttgatg actctcaaaa tgcttgtgat 2862121 gtcttttgat tttccttcta agcctttgac aacagcttca gcctgctgaa cagattgatt 2862181 aatcgagttc atttgtccga ctgtctgctg cacaaacttc tcacccgttc cggcgatttc 2862241 cgttgattgg atagatgcct ttgtaatatc tgacgatgtt tgtgagactt gctggagtcc 2862301 ttcattcatt aagttcagct gatgagagct ggattcaacc ttttcgcttt gctcctcgtt 2862361 tccgtttgag aactgctcaa tcgccatcgt aatatgctcg gtggctttac tcgtctgccc 2862421 ggcagatgcg gtaagctgtt cggaagatgc ggccacattg ttcaccgagt cctgaatagc 2862481 gctgatcaga gagcggagag attgtcccat ttcattgaag ctttccccaa gctctccaag 2862541 ctcatccttt gaatggattt cgatcgtttc ggtcagatcc cccctgctga tcgttttcga 2862601 tgattgaaca agacgtttta acggttttgt aatcgaacga acgataaaca gaattaaaat 2862661 tccgcctgcc acaatggaag caatcagcac aatcattcct gttgtcagca cagactttga 2862721 ggcatcctta atttcatcca tatacattgt gccggctatt ttccaaccag tcagttcgtt 2862781 tgtagtatag gtcatctttt tatcttcgtt attaagagta tactggagtt caccgctgtc 2862841 attcgcatac attttggcta cccagtcgcc tgaaagcttt tctccagcct tatggttctt 2862901 gtgggcgaca taggttttgt tttttgttgc aatgaaagca taaccttctt ttccgacctt 2862961 gatttgtttc atttgttcta acaatttatc aatggtaata tccatggcga caacgccaga 2863021 tccgtccttc agctcctgtg caatggtaat gaccatgctt ccgtcactcg cagccacgta 2863081 aggatctgtc acgacaattt caccgccggc cttcatcgca tcctggtacc aaggccgttg 2863141 tctcgggtcg tatccttccg gcaatttttc ttttggcgct tgtacataag tgccgttatc 2863201 tgcgccccca taaattctgg ctactccttg attaatagat acatattgtg aaaatttagc 2863261 tttgatctct tcttgatttg atttcccttt gaatgcggat cttttaagag attcactgaa 2863321 aaaggtgact gctttcgctt tttctcccag atcatttgta acagttgtat taaatgtatc 2863381 gacactgttt ttcgcatttc ccataatttc ctgatccagc tttccgctgg cgcttcggta 2863441 agagctaaat tctaatataa gaatagggat aatgagaatc gcaataaatg agacgattaa 2863501 tttctttgaa atagacggtt tcttcagcca attgataaaa gtcttcatgt cacttgctcc 2863561 ttcaggtttg atacagtata tatcggctgc ttaaaaaagt tttaaaataa aaaatggaag 2863621 aagttctttt tggctgtctt ctgccttttt aactttcatt gcccaagctc tttgcatatc 2863681 ttataaaaaa caaggggggc taaacatgat tattgtatca ggacaattgc tccgtcccca 2863741 ggatattgaa aattggcaga ttgatcaaga tctgaatccg ctcttaaaag agatgattga 2863801 gacgcctgtt cagtttgatt atcattcaat tgctgaactg atgtttgagc ttaaactgcg 2863861 gatgaatatt gtagcagcgg caaagacgct gcacaaaagc ggggcgaagt ttgccacttt 2863921 tttaaaaaca tacgggaata caacgtattg gagggtttca ccggagggcg ccttggagct 2863981 gaaatacaga atgccgcctt caaaagcgat tcgggacatt gcagagaacg gcccgtttta 2864041 tgcgtttgaa tgcgcaaccg caatcgttat catttattac ttggccttaa tcgatacaat 2864101 cggagaagat aaattcaatg ccagctttga cagaattatt ttatatgact ggcattatga 2864161 gaaattgccg atatatacgg aaacaggaca ccactttttc cttggagatt gtttgtattt 2864221 taagaatcct gaatttgatc cgcaaaaggc gcaatggaga ggcgaaaatg tgatactact 2864281 gggggaagat aaatattttg cccatggtct tggaatctta aacggaaagc aaattattga 2864341 taagctgaat tcttttagga aaaaaggagc cttacagtca gcctaccttc tgtctcaggc 2864401 gaccagactg gatgttccgt ctcttttccg catcgtccgc taaaaagccc catcgcctat 2864461 tttccggacg atggggtttc aaatgccttt cgttttcgat agaagggggc tgtgccaaaa 2864521 tattggttcg cagcccactc cattttttca aggtcatttc ttgtcacgat tggatcctgg 2864581 ctgctccatt tgataaagcg gacaaaatag tagcctttga taggaaccat tgtaactttt 2864641 gagtgaggcc agccttcaaa tacaaactca attttccctc tttttttata agaatattga 2864701 agaatgttca tatctgtcac ctcagtttat caagttacgt tcggcaaagc tcggtacgtt 2864761 tacatccatt gattaactat ccctcatgca ggctttccgg aaaacaaagg gtgaggcgcg 2864821 tgtctctttc cctcgctttt tatttcgcat atggacgaat gccaagcacg ccttcattcg 2864881 ataaagccgc agcgtgggcg ggtgtgacaa gccctccggc tatcggcgct tgttcagcga 2864941 tcatgctttt gtcataaaaa acagcctatt atcccatcat tttgatatag catgtccggg 2865001 tgcgaggccc gtcaaattcg cagaaataaa tgccctgcca cgttccaaga ataagccggc 2865061 cgttttccac aatgacatgc tgtgaagctc cgaccgtact cgacttcatg tgtgcagctg 2865121 tattgccctc catatggcgg tccagctcat gttcccacgg atatacctca tcaaaccttc 2865181 tgagcatatc ttttttgacg tccggatcgg cattttcatt aattgtaatg cccgcagtcg 2865241 tatgcggaca gtaaatcagc gctgcgccgc tcgttatacc tgtttcttga agaaacgctt 2865301 ccacctcccg ggtgatatct atcatttcat ctcgtttggt tgttttgatt tgcagtgttt 2865361 tcagcatttg tttctccttt cgtttgtccg ctctcatcgc ttaattcgtt ctgtgttctt 2865421 ttttttcctg ttaaaccgct ctcataaacc cgataaaaca aaaaaactcc agtctaaggc 2865481 tggagtttag caccatagat atattcttgc ttcatacggc tttaagagta ctgatgtcat 2865541 atgcttgtgc ggctctgttt caatatttga caagacgagt gcatctgatg acaatggcaa 2865601 tccagagtgc ctgaacaacg ccggtgttcc tgtcagattg gccgcaatca gtgcagtatg 2865661 gctctcgttt ttccgaagat atgcaaagat ttgctgatct tccggtaaaa tgagctcgta 2865721 tgtcccgtta ataaaaacat catatgtttg gcgcagcttg atcaagcttt tgtaaaaatg 2865781 gtaaacggat gttttatcgt ttttttgcgc ctcggcattc agccatttgt aattctcatt 2865841 gattccgatc cacggtttgg cctcagaaaa tccggcgtat ggaccagcat tccattgcat 2865901 cggcgttcgc gaattgtctc ttcccttttt ccagacaatc ttcatcacat cctcgtgtga 2865961 tgtgcctttc gctgtttttg tttcatacag gcgtttcaat gcgacatcat catagtcctc 2866021 aatagatgga aaagccacgt tcgtcatccc gagttcctgt ccctgataaa taaacggtgt 2866081 gcctttcatg agaaaataaa cagcggaaag cgcttttgca ctttctttca ggtacactcc 2866141 gtcgtctccc cacacagaaa ctgaacgggg ctggtcgtga ttctccataa acaaagcatt 2866201 ccagccgatc ccttccagac tgtcctgcca gtcagttaaa attcgtttaa atgcaacgat 2866261 atcaatactt tcattgatct ctacatccca caggccgaga tgctcaaatt gaaaaatcat 2866321 gctgaatatg ccgttttttt ctccagccca atcagctgct tcttttgcag cgacgccgtt 2866381 tgcttcacca actgtcataa tcggatagcg ggaaaatgtg ttttccttca gctctgttaa 2866441 caaatccata atgccgtcag cattcatatg ataaggaaag gaagggacat agtccagtcc 2866501 ctttggattc ggcatgtcag gaaacccttc ttttttctta atatgcgtaa tggcatccac 2866561 ccgaaatccg tcaattcctt tatcaagcca ccaattgatc atgtcataaa cggcattcct 2866621 caccttttca ttttcccaat tcaaatcagg ctgtttttta tcaaaaaggt gcagataata 2866681 ctggcttgtc ttttgatcat actcccaagc cggcccgccg aaaatgcttt cccaattgtt 2866741 gggcgttttt ccgtttttgc cgtctttcca aatataccag tcgcgctttt ccgagtgtat 2866801 ggatgaacgg gattctatga accatggatg ttcgtcgctt gtgtggttca caacgagatc 2866861 cataatcagc ttcatatcca gatcatgaat gtcaccaagc agctcatcaa aatcttccat 2866921 cgtgccaaac tcgcttaata tgttttgata atccctgata tcatagccat tatcggcatt 2866981 cggtgaatca tacagcgggc aaatccatat gacgtcagcg cccagctctt ttatgtaaga 2867041 aagcttggtt ctgattcctt gaatatcccc gattccgtcg ccatttgaat ctttaaaact 2867101 gcgggggtaa atttggtaaa ctacggcttc cttccaccaa gcctttttca tacagccact 2867161 ccttcccagt gtaccgttct tatatatcct atgtagaaaa aggtctttac agcattgctt 2867221 tttaagaaat gacttgatga cacaaaaaac agccgtttgt tccccggctg ttttttatca 2867281 aaaatcagtt ttttttattt ctacaaaacg gatgtggtga tcttcggcgt cgaggatttt 2867341 aaattcacag ccctccgcgt gtatcacatc ccctgctttc agctccattt tttgcgttag 2867401 aagccagcct gcaatcgtat caatttcttc attttcaatc gcaatgtcga gaaggtcatt 2867461 cacttcgtct attagcgctt ttccatccat cacataatgg tgctcgccct ttttcaggat 2867521 gtgcggtgtt tcatcctgat catactcatc gcggatttcc ccgacgattt cctcgataat 2867581 atcctctaca gtgacaagcc ccgccgttcc cccgtattca tcgacaagaa tcgccatgtg 2867641 aatccgctcc ttctgcatgc ggattaaaag ctgctgaaca ggaatgcttt caatgactct 2867701 gataacgggc ctcatgattt gattcagctt tatcggctgg ccgagaaaat aagctttaaa 2867761 catatctttg ctgttgatga tccctaaaat atgatccttg tcatctttga tgacagggta 2867821 gcgtgtatac cgttcattaa tgatgtgatg aattgcctct tcaagcgact gctccagaga 2867881 gataaccgca atttctgtcc gcggaatcat aatctctctc gctacccggt tgtcaaattc 2867941 aaaaatctta tttacatagc ggaattcaga ctgattgatt tctccctttt catagctttc 2868001 agaaaggatc agccttagtt cctcttcgct gatgacaacc tgatgctcct ttaccgaatg 2868061 aaagccaaac aatttcacaa gaaaacttgc agagccgttt aatgctttaa taaacgggta 2868121 cgtgatttta taaaaccaga tcagcggctt tgcaatccat aagcttacag cttcagcttt 2868181 ttgaatagaa accgttttcg gggcaagctc ccccatcacc acatgcaaaa aagtgacgat 2868241 gataaatgca actacaaatg tgacaatgtg gttaaacggt tccggtatgc ctgtcattgt 2868301 aaataaggga tgaagaaaac gttcaaatgt aggttcacca agccacccaa ggccgagggc 2868361 tgtaatcgta atcccgagct ggcaggctga taaatactcg tcaagattgg agatgatttt 2868421 atgtgcggct agtgctcggc tgtcaccgct ttcgatgagc tgattgattt ttgaacctct 2868481 gattttgacg atcgcaaatt ccgctgcaac gaaaacagcc gtaatgccaa tcaaaacaaa 2868541 aatggcgatc aattgtaaaa taagcaaaaa aagcccttac cataaatggt aaggggccac 2868601 ctccttaacg ttaattctca tcacgaccgt ttaagaaaat catcacaaaa cgaagtagtt 2868661 caaacaggga aaccagggcg gcggccacat acgttaaggc agcagcactc agcactttat 2868721 ttaccccatt ttcttcattg tttcggatga atccttctga cacaataatc tgcttcgcac 2868781 gtgaacttgc attgaattcg acaggcaatg taatcagctg gaaaaagaca gccgctgaaa 2868841 acagtatgat gccaagcccg atcaaattca ggctgccgag aagcatgcct cctaagaaaa 2868901 gcaaaggagc tacaccggat gcaaaattca cgactgggaa gattttatgt ctcagcacaa 2868961 gcgcaccata tgactcctga tgctgcaagg catgtccgac ttcatgggaa gctacggata 2869021 tggcggaaat tgagcggccg taatagaccg gctcagataa acgcaccacc cgtcttgtcg 2869081 ggtcgtaatg gtctgttaaa gtgcctctta ccggttcgac cggcacgtcg taaagaccgt 2869141 ttatatctaa aatccgtctt gccgtttctg cccctgtacg tccgcttgag gcttccactt 2869201 ttgaatattt ttcaaagttg ctctttactt taaattgtgc ccaaaacgac aatcccaatg 2869261 cggctattgt taaaaatata aacagcattt tttcatcatc ctttgttcat gatcatttct 2869321 ctattacgat tattttaatg agttttcttt ctcgtgtaca gaaatgcgct ttttcttccg 2869381 gcttggagca cacaatccaa tcagcaaaaa gaacaggcct gctgaaaaca aataaaaggc 2869441 gaaactgccg gccagttctt tcagaaaatg aagccaggag aagcttccgg aaaagtgatt 2869501 atatgaattc aaatcgaaaa taaacaaaat caccgcggat gccgccagct gcgtaccgat 2869561 taaaaccacg atcgttcttt gaaagatcgt catctttttc atcctttttg ttttagttta 2869621 tggagaaatc cggttttata tgttttgtac attttttgaa aaacatcacc ggaagtggga 2869681 catactgtta gaaaaaagca cgggtgtgat ggaagctatg aaagtgacga gtgaggaaaa 2869741 ggaacagctg agcacagcaa tcgaccgaat gaatgaagga ctggacgcgt ttatccagct 2869801 gtataatgaa tcggaaattg atgaaccgct tattcagctt gatgatgata cagccgagtt 2869861 aatgaagcag gcccgagata tgtacggcca ggaaaagcta aatgagaaat taaatacaat 2869921 tattaaacag attttatcca tctcagtatc tgaagaagga gaaaaagaat gaaatcaaat 2869981 cggatattta tttcatggct caggtggccg ttatttatcc gaatcggggt tattatttta 2870041 tgtctgattc ttttgttcgg ccaaatcatt tatatacttg agcctaagca gttcacttcg 2870101 gtattcgaag gtatttggtg ggctgtcgtt acggtttcta cagtcggtta tggagactat 2870161 gtgccgcaca ctccgctggg acaggcagcc ggaatactgc tgattttgag cggagcaagc 2870221 tttgtcacag cgtatttcgc tacgttatca gcggccgcat tcagcagaca gcatcgctac 2870281 attgaaggaa aagttgctta caaaggccgg gaccacatca ttctgatcgg gtggaatgaa 2870341 aaaacaaacc ggcttttgaa ggaccttcag cttgccgccc cttccaaaac agtcgtacta 2870401 atcgatgaat ccttaacaga aggcccgctt attgaaaacg ttcatttcat acgcgggcac 2870461 gctgccgatg atgggacact gaaacgggcc aatattactg aagcggaatc agtgatgatt 2870521 actgccgatc agtataaaag tgaaactgat gctgatatgc tgtcagtgct gactctttta 2870581 tctgttaaag gtcttaatcc ccttgcttac tgcatcgtcg agattttaac tgaccgtttt 2870641 gtcaccaatg cggaacgggc aggcgcaaac caaatcatcg gaacttcaga atttatcagc 2870701 cgggcgatgc tgcagcatta ccaagtcaag ttacggccgt ctaaacagca gaacggaatc 2870761 aagctgacac ttgatcagca tgtggagctt cttgctgttc ctgacgaact aaagggagcg 2870821 gcttacaaaa cctgtgttct ctatttcctt gatcacaaca caacaattat aggcatacaa 2870881 aaaaaggagg ggccgatgct ttcccctcct cttacataca aggtgctcga aacagatcaa 2870941 ttccttgcca tctagtgtaa cagaacatcc tccaattctt tcacgagaga ggcgccgata 2871001 tccaaaaatg ccggatcaat ttccgcgtcc cgcctttccg gttcggaaaa ttgattaaac 2871061 agtgattgga aaggccctcc ctcggcgtga tcgtcaacat ccgcctgaaa cacctgtctc 2871121 agcataaatg gcgttccgat ccggacggcc gcccctcgtt catcgagact gccctgtacc 2871181 gcattgacgg gaattcttaa aaataaatag ccgtctctat catcaatttt ataatcaaag 2871241 tagccatgat cgtattccca gccgccgttt atcacataac cgagcggctt catcacttgt 2871301 tccagttctt gaagcagaaa agactgccca tctatcgcgg aaggtattgg tatcatcaga 2871361 atgccccttt tttcacttat cctgtcccgc cgaacaagac ttcattcaga ggcgcctaca 2871421 tggaaatcgt tgtttctttc gcgcggccaa caggaaagaa agcgcattca attaagaagt 2871481 aaacagccat tgccgctgca agccatacag ctgaatccca agacacataa acaaccgttg 2871541 catagagtcc taatttagtg aaaagagtat gggttcgttt taaatgcaaa atccgatgta 2871601 ccgcatcggt aaaaagggca agcggcaaac caatgagaag aaaggagtgg atgaaaaaat 2871661 gtgacagcgt gccgccaaag cttgaagaaa accctgtata cacggcatca aaggagataa 2871721 ggaaacttaa aatagctgca gaaaaaccgg caatgatgag atgtttaacc aattgtttca 2871781 tgaacatcag cacctttctg attttataaa aagccgaccg gcaaatgcca gtcagctttc 2871841 tcacattaat cttccagacg tttttcaagc tctgcttttt tctcttcaaa gccaggtttg 2871901 ccgagtaacg caaacatatt gactttatac gcttctacac caggctggtc aaacggattg 2871961 acgccaagga ggtaaccgct catcgcgcag gctttttcga agaaatatac aaggtatcca 2872021 aaagtatatg cattcagctc aggaatgtta acgattaagt tcggaacatt tccgtctgta 2872081 tgggcaagca ttgtaccttg gaatgctttt ttgttaacga aatcaacagt tttaccggct 2872141 aaatagttca agccgtcaag atcgttatcc gcttcctcaa ttgtcagttc atgtttaggc 2872201 ttctctacgt tcaggaccgt ttcgaataaa tctctgcggc cttcttgtac atactggcct 2872261 aaagaatgaa ggtctgttga atagttcgct gaagaaggat aaatgccctt ctcatctttc 2872321 ccttcgcttt ctccgaacag ctgcttccac cattccgcaa agtattgaag cgccggttcg 2872381 tagttgatga gcatttcaat tgttttgccc ttattataaa ggacattgcg aacaaccgca 2872441 tattggtatg ctgggttatc ttccagttca gatgttgcaa aatctttgct cgcatccagg 2872501 gcgcctttca tcatgtcgtc aatgttgacg ccgctgacag caatcggcaa gagacctaca 2872561 gctgttaaaa ctgaataacg gccgccgaca tcgtcaggaa ttacgaatga ttcaaagcct 2872621 tcttcgttag aaagcgtttt taatgcgccg cgctctttat cagttgttgc ataaatccgc 2872681 gctttcgctt cttctttacc gtatttctct tcaagaagct tgcggaaaat acggaaagcg 2872741 attgcaggtt cagttgtcgt acctgattta gaaatcacat taatagagaa gtcaacatct 2872801 tcaagaagat ccatgacgtc tctcatataa gatgaactga tgttgttccc gataaaaatg 2872861 acttgcggat tgccgcgttt tgcttttggc aaagtgttat aaaacgcgtg attcagcgct 2872921 tcaatcgctg cccgcgctcc aagataagaa ccgccgatgc cgacaacaag caagacatca 2872981 gagtcagatt tgattttttc cgcgcttttt ttgatgcgcg cgaattcttc tttatcataa 2873041 tgttcaggga ggtccaccca gcctagaaaa tcgctgcccg cgcctgtttt ctcatggata 2873101 ttatggtgtg ctgtttttac aaagtcccgc aggtatgtaa gttcatgttc gttgaagaaa 2873161 gtcaacgctt ttgagtagtc aaagcgtaca tgcgtcattg cttgtccctc cataacggta 2873221 taatgttttc atctttcact ttatatgaac ttatctgtga aatcaagtca agaagaaagg 2873281 gcggaatgac tggattccgc cctttgggtt tatagagacg cgcgaaggat ggcaagcacg 2873341 tcatctttgt tcagtttttg gaagttgccg aagccgccgt gttccatttc cttggctgcg 2873401 atatcagcaa tcagctcaag cttttcttct ccaatattgt aatcagcaag acgagaaggt 2873461 gcaccgaggc ttgtccagaa cgcagacagt ttatcgattc cttcaagcgc aatttcttta 2873521 tctgttttgc cttcagtatc aatgtcaaac atgttgagca taaggttttt aaaacggcct 2873581 acatttgtat caagcgtgta tctcatccaa tttgggaaca gtattgccaa accgcccgcg 2873641 tgcggaatat catatacagc tgaaacagcg tgttccattg tatgagaagc ccagtcaccg 2873701 aagtatccca tttggagcgt gccgtttaaa gcaatagtac cagcatacaa aatcgtttca 2873761 cgaagttcgt agttttccag atcttcaaga agcttaggag ctgtttcgat gaccgtctgc 2873821 aaaacagcaa agcacattct atcctgaagc ggcgtgtttt caacattatg gaagtattgt 2873881 tcgaatacgt ggctcatcat gtcaaccatg ccgtatactg tttgattttc tggaacggtg 2873941 aacgtatttt cagggtctaa aatagagaaa cgcggatgag tgacattgct gccccataca 2874001 aatttctcgt ttgtttccca gtttgtaatc acggaatcag ggttcatttc agaccctgtt 2874061 gcagcaagag ttaaaacagt gccaaacggc agcgcatcct ccgctgttac ttttttgctg 2874121 aaaatatccc aagcgtcacc gtcatatttg acgccagctg cgattgcctt tgtacagtca 2874181 atcacactgc ctccgccgac agcaagcaga aaatcaatgt catgctctct gcaaagtcct 2874241 atgccttttt ccactgtcgc aagacgcggg tttggctcta cacctgacag ctcatgaaca 2874301 acagcgccct cttcttttaa aatgcctgtg acttgatcat aaaggccgtt gcgtttaatg 2874361 ctgccgcccc cgtaaacaag cagtacattc ttgccgtatc gtttgaattc ttttcttaat 2874421 tgttcaagct gaccttttcc aaaaatcagc tttgtcggat tataataagt gaaattttcc 2874481 atagtaaaac ctccaaatga tgctggtaaa aaacagattt tccattgtaa cataagttga 2874541 caaaaaagaa aaagggaagc agccaaacgg ctatttcccc tttttttata gtgatgcttt 2874601 caaaattgac agcacatctt ctttgttgag tgatttaaat tggccgaatg taccgttagc 2874661 cattgccttg tcagcgattg tgtcaagctg ctcatcatta atatcataat cagcaagacg 2874721 gttcggagcg ccaagacttg tccagaatgc ggacagctta tcgatacctt caagggcaat 2874781 ttcttcatcc gttttacctg cttcttcaac atcaaacacg cgaactgcaa gctgtttcat 2874841 gcgggcaggg ttttcagaca atgtgtgtct catccaattc gggaacagaa tcgccagtcc 2874901 gccggcatgc ggaatatcat aaacggctga tactgcatgt tcaatattat gagtagccca 2874961 atcccctctt gcccccatag aaagcatgcc gtttaatgcg attgttcctg tgtacaggat 2875021 cgtctcacgc aattcgtaat tttcgagatc attgatcagc ttaggcgctg tttcaatgac 2875081 tgtacgcaaa agtgattcac acatgcggtc ctgatacggc gtgtttgata catgatggaa 2875141 gtattgttcg aatacgtggc tcatcatgtc aaccatcccg tagatcgtgt ggtttttagg 2875201 tacggtgaat gtattcaccg gatcaagaat cgagaattta gggaatacga gcgggctgcc 2875261 ccagccgtat ttttcttttg tttcccagtt tgtaataaca gatcctgagt tcatttctga 2875321 accagttgca gcgagagtca ataccgttcc gaatggcaaa gcatcttttg gctgatgctt 2875381 tttcgtaacg atatcccacg catcaccatc atacttcgct cctgcggcaa tcgcttttgt 2875441 acagtcgatt acgcttccgc ctccgacagc cagcaagaaa tcaatgtttt gttctttaca 2875501 gatggcaaca cctttattaa cagtcgacac acgaggattc ggttccacac ctgctaattc 2875561 atgcacggtc gctccggctt tattcagctg ttcaatcact tgatcataca ggccgctgcg 2875621 tttaatgctg ccgcctccgt acacaagcaa tacgtttttt ccgtaaggtt tgagttcctc 2875681 cggaagtctt tccacttcgc cgcgcccgaa aattaatttg gtcggattcc agtatgtaaa 2875741 gttttgcatg acatctcctc cttagatttt ttattatgca gaatgtcctc accacatgta 2875801 aagcaatcag ctctcaccga tcagcatacc agatggtttt attttgcaag gtgctgggaa 2875861 agaagctgat ataagcgagg gcaggccagc ttccctcata tggagaatgc atgtatagat 2875921 tctccaatat gtcacaatct ataactgttt taataattca tggaggaggt tgcaaaacat 2875981 gagtaccatt caaagaattt gtcttgtatt aaccatcatt ggcgccatta actggggact 2876041 gatcggattt ttccaatttg acttagtagc ggctatcttc ggcggccaag ggtcagctct 2876101 ttcccgaatc atttacggac ttgtcggaat cgccggctta atcaacctcg gtctgctatt 2876161 taagccaaac gaggaaagat cacgtgaaga agcagcaaat cctgaaatgc gataggatat 2876221 caatcacgct gaaataggat tttgcatgaa atcaaaagca ccgaacattc ctgtccggtg 2876281 cttttttcat gcttattttt tgataaggtc tttgcggttg gacatttcga tccactcttc 2876341 aagcttatct tttaatgtgt tgaaaccttg tggtgtagaa gcttcttcgc ttacttgagc 2876401 agctttaggt tttcttggtt tgctttcttt tttctcaggc gcagcttgtg tcgcacgaat 2876461 tgaaaggctg attttgcctt tttcttcatc aacagcaagt acttttactt gtacttcgtc 2876521 gccaactgaa aggtgctcgt tgatatcttt tacgaaaccg tgagtcactt cagaaatgtg 2876581 tactaaacct tgagtttctt catctaatgc aacaaacgca ccatacgctt gtaatcctgt 2876641 aactttacca gtgtaaacac tgcccacttc aaattttgct gccattcata acaactccta 2876701 agttaaatta aatatctgtt tatacgcaat ttaaaattat atcacacatg tcttatttcc 2876761 gcaaagaaaa cttttttata aaaaatcagg tttatgcaca gcaaaaaggg ggtaaactga 2876821 aaataccaaa ggctttctag tattcccccc ttttattgga tgcgaacaaa aggttcgtat 2876881 ctttttttat gttgttttgt gcaggaagcg tttcattctg actaacgctt cttgaagctg 2876941 ttcaatcgag gttgcgtatg aacaacggat atatccctca ccgctcggac caaacacact 2877001 tccaggaaca actgccactt tttcctgcgt cagtagctcc tcggcaaact gttctgaact 2877061 cattcccatg cttttgatag atggaaaagc atagaaagcg ccgcccggat gatgacagct 2877121 gagaccgatt tcattgagcg attctacaaa cagattccgt cttcttcgat agcttttttt 2877181 cattttttct acgtcttcca tgccgttctt caggccttca agggcggcaa actgcgccat 2877241 tgcgggcgcg cacatcatcg catactgatg aattttaagc atggcatccc gaagcaagga 2877301 tggtgccgcg gcaaaaccga gcctccagcc cgtcattgca aatgcttttg aaaagcctga 2877361 gatgactacc gtccgttcct tcattcccgg taatgccgct atacttgtaa attcctcatc 2877421 atatgtcagc tccgcgtaga tctcgtcggc taagacgatg acatcatgtt ttttggcaaa 2877481 ctcagcaatc tcattcagct cttccttcga ataaaccgaa cctgtcggat tcgatggtga 2877541 gcagatgaga atggcctttg ttttttcagt gactgccgct tcaaaatcag cagccgttgc 2877601 tttaaatcct ttgtctgccg ttgtatgaac gtgaaccggg ataccgcctg ccaaagaaac 2877661 aagcgcatcg tacgcaacaa aacacggctc aggaatgatg acttcctcac ctggattcac 2877721 aatggcgcgg atcgcaatat ccaaagcctg acttgccccc actgtcacaa tcagctcatt 2877781 atctggcgag tagctaaggt caaacctgtt gctcaaataa cggctgattt cctcccgcaa 2877841 tgagtataaa cccgcattgg ccgtgtatga cgtatatcct tgttcaagag agagaatgct 2877901 tgcttcgcgg acattccatg cggtaacaaa atcaggctcg ccgacgccta aagaaatgac 2877961 gccttccatc gttgccgcca aatcaaagaa tttgcggatg ccggatggtt ttatttgttg 2878021 tacatagtct gataaatacg aagtcattta cggtgacacc acgattcttt tgtcgtcgtc 2878081 tcctgtttca aacactttgc cgtcatgctt gtattttttc aggataaaat gggttgtcgt 2878141 agatacaact gaatcaagcg ttgagagttt atccgaaaca aaacgcgcta cgtcagacat 2878201 cgaattgccg cgaatcacga cagacaaatc gtatacgcct gacatcaggt aaactgattc 2878261 aacctcttgg aatcggtaaa tccgttccgc cacttcatca aaaccgacgc cccgcttcgg 2878321 cgttactttg acgtcaatca tggccgtaac gccctcatgt ccgtcgactt ttcgccagtc 2878381 aatcatagcg gaataatcga taataacctt ttctttctcc agtttgtcaa taattgtttt 2878441 cacttcattt acagggatgc ccgccatctt tgcgattgtt tctaaatcgg cgcggctgtt 2878501 ttcgtctaaa atttctaata tttctgtttc tttttctgtc aatttcattt gattcacacc 2878561 tttgcaatgt caagaaatct catgacatta tatcacgttt tttgacgaat gctaagaaaa 2878621 aacgaggaga aacttccgct agaattgaca atttcagggc ataatacaac catcaaaaaa 2878681 agggagtgac acagaatgga ggcggtttca ccaataaggc ggtttacggt cgatggagtc 2878741 aatgtatact acgaacatta tcaaaatccc ggcaggcaaa cgctggtctg cgtacacggt 2878801 tttttatcat ctgcattcag cttcagaaaa gtaattcctc tccttcggga caagtacgac 2878861 atcatcgcgc ttgatttgcc tcctttcggc caatctgaaa aatcaagaac gtttatctat 2878921 acctatcaaa accttgctaa gcttgtcatt gggattttgg agcacttgca agtgaaacag 2878981 gctgtgcttg tcgggcattc tatgggcggg cagatatcgc tgtctgctgc tctccaaaaa 2879041 cctgagcttt tttcaaaggt tgtgctgctt tgcagttcag ggtatttaaa acgttcacac 2879101 ccgacgatta ttttcgggac ccatatcccg tattttcatc tttacatcaa acgctggctc 2879161 tcgaaagaag gcgtgatgaa aaatttatta aatgtggtgc atgacaaatc gctgattgat 2879221 gaggagatga ttgacggcta tggcagaccg tttcaggacg agcagatttt caaagccatg 2879281 acaaggttta tccgccacag agaaggagat ttagaacccg agcaattgaa gaaaatgaac 2879341 aagcctgctc tattgatttg gggcgaggag gatcgaattg tcccaatgga gatcggtaaa 2879401 cggctgcacg cagatttgcc taattccgtg ctgtactcac ttggccagac cggacatctg 2879461 gtgcctgaag aacggcctga acttatttct gaacacattg ctgattttat caaataacaa 2879521 aaaaaccggt gctgaaccgg tttttttaag gcgtgcagga gctgctgttt ttaatgaata 2879581 aaagctggcc agccacttcc cggcagctgg cgatcggcag cgtttgttca aaagaagttt 2879641 caaatatttg ctgaatgctt ttcgccagca agtcgggatc gttttcatca tagactgcct 2879701 gcacgacatc aacagcctcc gtttcgtaaa actcttctcc atatttaaac gggtcccatt 2879761 tggcaatgat cttaatcatt tccctgaccg catgactttc ttccatattc atcaccgctt 2879821 ataataaaat ttgcagttct atcttatcat agtgaagctt agaagaataa acatacatga 2879881 gggggtaaca gaatgaactt tgataaacga gaagaacgcc ttggcaccca atcggtcaaa 2879941 tgggataaaa caggcgaatt atttggcgtg acagacgccc tcccgatgtg ggtggcagat 2880001 atggattttc gcgccccgga agcgataact gaagcgttaa aagagcgtct tgaccacggt 2880061 atttttggtt atacaactcc agatcaaaaa acgaaggatg ctgtgtgcgg atggatgcaa 2880121 aacaggcacg gctggaaggt aaatccggaa agcatcacat tcagccccgg cgttgtaaca 2880181 gctttgagca tggcggtaca agcttttacg gagccgggcg atcaagtagt tgttcagcct 2880241 ccagtttata cgccttttta ccatatggtg gagaaaaacg gccggcacat tttacataat 2880301 ccgctgctag aaaaagacgg cgcatatgca atcgattttg aagatttgga gacaaagctt 2880361 agtgacccaa gcgttacatt gtttatttta tgcaatcctc ataacccttc tgggcgttca 2880421 tggagccggg aagatttact gaagctaggc gaattgtgcc ttgagcatgg cgtcacagtt 2880481 gtatcggatg aaatccattc cgatttaatg ctgtacggac ataaacacac gccgttcgct 2880541 tcgctctctg acgatttcgc tgatatttcc gtgacatgtg ctgctccaag caaaacattt 2880601 aatatcgccg gattgcaggc ttcagcgatc attattccgg atcgcctgaa gcgcgccaag 2880661 ttttccgcaa gccttcagcg aaatggttta ggcggactga acgcgtttgc cgtcactgca 2880721 atcgaagccg cgtattcaaa aggcggaccg tggcttgatg aattgatcac ttacattgag 2880781 aaaaacatga acgaagcgga agcctttttg agcaccgagc tgccaaaggt caaaatgatg 2880841 aagccggatg catcatactt gatttggctc gacttcagcg cttacggctt gtccgatgca 2880901 gagcttcagc aaagaatgct aaaaaaagga aaagttattt tagagcccgg gacgaaatac 2880961 gggcctggcg gagaaggatt tatgcgcctg aacgccggat gctctcttgc aaccctgcag 2881021 gacggcctgc gccgcatcaa agccgcatta tcgtaaatat agctgtaaac gcctttacgt 2881081 cttcatttgt aaaggcgttc ttaataaagg aattttatat tttacttcta atatttagtg 2881141 ttataataga ttcatatttt atacgaaagg atttcacacg aatggaaatt ctaaaagact 2881201 atcttctgca catctgcttt attttgtttc ctattcttct ttaccaagtg ttttggcttg 2881261 gaaaacctgc gattcttgtg ccaaaaataa acagcggttt ggtcacgctc ttcgcctgcg 2881321 gcgcctccgt tttatgcatt attttcccga ttcatgaaat ggactacata caatacggcc 2881381 ttcagatgat tcccgttatc atttgtttat tttacattag taccgcttcc ggacttacag 2881441 tcgccgcatc tgtcctatgt tttgaactgc ttttttacga accttccgca atgtttgttt 2881501 tcactttgct gccttttctt atcattatcc caatcttatt tcagaaaaaa tggccattca 2881561 tgtccaaagc gaaaaaactg ctgctgtctt tattgatcag ctgcgtggag attttcctat 2881621 ttttcgcctc aagctggatt ctttccgcct tgaatatttt aaattttcaa aaatcaggaa 2881681 ttttcgttta cgaggcggca gtctcagggc ttttccgctc cagtgttctt ctattaagca 2881741 tctatattat cgaaagcatc gccgaaaata tcgccctgcg ttcacagctt atccattctg 2881801 aaaaaatgac gattgtgagt gaactggcag cgagcgtcgc ccatgaggtc aggaatccgc 2881861 tgacagttgt ccgcgggttt gtccagctgc tttttaatga cgaaacccta caaaacaagt 2881921 cgagtgcgga ttacaaaaag cttgtactgt cagagcttga ccgggcgcaa ggcattatca 2881981 caaactatct cgatatggcc aaacagcaat tatacgaaaa agaggttttt gacctatctg 2882041 cccttatcaa agagacaagc tcccttatgg tgtcgtacgc caattacaag tcagtaaccg 2882101 tcgaggctga aacagaaccg gaccttttga tatacggaga cgcaacaaag ctgaagcagg 2882161 ctgtcatcaa cctgatgaaa aacagtattg aagcggttcc tcacgggaag gggatgatcc 2882221 acatatcagc caaaagaaac ggccatacga tcatgattaa catcacagac aatggggtcg 2882281 ggatgacaga ccatcaaatg caaaaactcg gcgaacctta ttattcctta aaaacgaacg 2882341 gaacgggact cggcctcacc gtaacctttt ccattattga acatcatcac gggaccattt 2882401 catttaacag cagcttccaa aaaggcacta cggtgaccat taagcttccc gctgatcttc 2882461 ctcactagca aatcgattgg aactttaata gaataaatgc gaggtgatga cagatgagca 2882521 cgtttgagac aggctctatc gttaaaggat tttacaaaac aggtgtatac ataggagaaa 2882581 tcacggcttg caggccgcag cattatttag tgaaagtgaa agcggttctt acccatcccg 2882641 ctcagggaga ccttcatcat ccaaaacagg cggatgtgcc attttttcat gagagaaaag 2882701 cgctcgcata tggtgaacag accaatatcc cccaccatat ggtgaagcct tatgacggtg 2882761 aagtgccgga ttataccgaa tctctgcggg aggcgacagc acagatgaga gccaaattga 2882821 atgaggatgg ttcggagtgg gcaaagcgct cccttcataa tctggacatt ttagaaaaag 2882881 aatattttaa ccggccataa cccagtctga caaaagattg ggttttttac gtcgcgcgct 2882941 tcaacagttc ggttaaatcg attctctcgc cgattgtggg cggttttggc ttttcgagat 2883001 actgcttatc ctgctcaaca agcttaaaaa gtttatatgc tgtgagagca tcatcaagcg 2883061 ctttatgatg ggtgccggtt ccggaatctc catactcttc ggcagctttc cataaacccg 2883121 tcaatgtccg gtctccaaaa aagtttttgt attcaagcga taaatctctc atttctccct 2883181 taaacgggaa agggatatgg ttaaacatac agttttgctt cagcactttc atatccatgt 2883241 ttccccacgt aataattgtg ctgtttttct caggatccag ctcgtttagt ttacggatga 2883301 aatcctcgaa tctcattcct tcgtctacct gtttttgggt tatttttaaa aatgatttgc 2883361 agcgtttcgt aagcttcggg aactttttcg gtctaacata gctagaaaac gtctcaacca 2883421 cttcatcatc aatcgacttt acaattccgg cttcaatgat ttccgggaag aagttttgag 2883481 gactgtactt tccatcaggc attgtaaatt cgaaatcaat aatgagtaag ctgtttgtcg 2883541 tcacctttta cacctgcctt tcctccgatc agaaaatgct atctttatag tatatcaatt 2883601 ccccttctcg acatttcttc attttctaaa aataatgaat tttcccagcc gcttcgtttc 2883661 ttttaaattg tgaatcgttt ctttataatt agtaaggaac ccgaaataat aagaaggtga 2883721 tgttatttct atccgtaaga aaaactttgt cattgtgtgg ctggcgaact tttttgtctc 2883781 cgctagcaca acgatgatcg ttccttttct ctccttatac attgagacgc tcagctcttt 2883841 ttcaaacggc tttgtgcaaa ggtggagcgg ctatgtgttc ggcattacat ttctcatggc 2883901 gtttttggta tccccgtttt ggggacggtt cggagacaaa cgcggataca agaaaatcct 2883961 tatggcaacc ggaacaggca ttgccctcag cattttcttc atgggctttg ttacatcggt 2884021 gtaccaattg ttttttctgc gtatggcaat gggtcttgta accggattca tcccgacatc 2884081 tcttgcgatg atttcggcac agactccgaa gagctcagct ggcaaaacac tcggcacgct 2884141 gcaaatgggg caagtgtccg gaagcttgtt cggcccgctt ttgggaggca tgcttgctga 2884201 tcgtttcggc tttacgtata ccttttttat cacatccttt gtgattttct cgtctgttct 2884261 tctcgtgtta tttggtgtca aagaaaagca tcttgcagag aaaacagcca aacgtacgtc 2884321 ttactcgaga aaagaagtgc tctcctatat ttttcaccat ccggcgctgt gggtcatgat 2884381 gctgttaacc atgctgattc aaacaggcaa tttcagtatc cagcccctgc tcgctttata 2884441 tgtaaatgag ctgcacggac ctgtcaatct tgcctttttc tccggcatgg cattttcagc 2884501 aacggggctc ggaagtttgc tgctggctag aaaatggggt gatctgggcg accgctacgg 2884561 ccaccgccgc attttaatcg gacttttgct cgccgcctct ttctttttta ttccgcaggc 2884621 gctcgcgtcc tcactcagcg tgctccttgt tttcagattt ttattcggaa tggcgatggg 2884681 cggtttgctg ccatgcatta cggcagcgat ccgcgttcag gctcccggca gcattcaagg 2884741 tgaagttctc ggctacaatg tcagctttcg ctttttagga aacgtgctcg ggcctctgct 2884801 cggcggaatc atatcgagcc attttaccat ttcggccacc ttttacgtca cggcgtttct 2884861 ctttttcgcc ggcgcctgca tgctttggat catgcagaaa cttcggaaag attcttatgc 2884921 caaagcaagc tgattccgag aaaaaactaa ggaatcttct aaatttaacc ttctcgtaat 2884981 ctcaaaagaa tggtacgata tggctagaat ttaggagaaa agagagtgac catgttacga 2885041 aaaataatcg gatggatttt gctcctttgc ataatcccat tgtttgcatt tacagttatc 2885101 gcttccggaa aagaagtaaa acaaatgaag tccctggatc aggtgcttga taaaaatatt 2885161 gatctgaaag atatcagcct tgttcagaac agctacatgt atgacaggga cggctccctt 2885221 gtctcggaaa tcgtcagcga ccacgaaaac cgtgtgctcg ttccatttaa caagattccc 2885281 gaggaagtca aacagatttt cttaacatct gaggaccgcc atttttacga gcataaaggc 2885341 tttgacttta tgggaatggt gcgggctact gcttctaacg taaaagacaa gaaaattgac 2885401 cagggtgcca gcaccatcac acagcagctt tcaagaaact tgtatttgag ccacgaacgc 2885461 tccttcagcc gcaagctgac agagctcgcg tattcctatc agctggagaa aaaatatacg 2885521 aaaaatgaaa ttcttgaagc ttacttaaat accatttatt tcaacaacgg tgtttacggc 2885581 gtcggttcag cagctcaatt ctatttcagc aaaccgctga aatctctcac agtgggagaa 2885641 atggctttta tctgtgctat acctaataac cctacattat atgatcctct caagcatttt 2885701 gactacacga aaagccgtca agaacgttta cttaaagggc taaaagatgc cggggtcatt 2885761 acggacaaag agctgaaaaa agccgtaaaa caaaaaatca aactggatgt tgaaaaaaga 2885821 gaagacaaat atcctgacta cgtttcctac gtcaatgatg aattcactca gctggtgtct 2885881 gaatcagaag gctttgataa acgccttcaa aaagcatcag gaaaacaaaa agaaaagatc 2885941 gagaacgagc tgtccgcaag agtcagcacg ctgatgaaag acggagtgaa aatttatact 2886001 gcacttgatc cgtacatgca aaatcaagtt gtggcacaaa tgaattccaa gctcccgtat 2886061 gcggacgtac agggcggagc ggctgtgatt aatcaccaga cgcatcaaat cattgctcta 2886121 tccggcggga aaaactatca aaaatatgac tttaaccgcg cctaccaggc gtacaggcag 2886181 ccgggttcat ccattaagcc gcttcttgat tacggccctt atattgaaca gaccggcgcg 2886241 acaacaagca gcaccattga tgccagcaag ttttgcagca aagactactg tccgcaaaac 2886301 tacaataacc gcacttacgg cacagtgacg cttgatacgg cgtttaaaaa ttcatataat 2886361 accccggcta ttagaatgct cgaccgcgtc ggcatccaaa aggcattcag ttatattgag 2886421 ccgtatcatt ttgccaaact tgtcgacagt gactatcttc ttccggcggc gcttggcgga 2886481 tttacaaacg gcatgacgcc tcttgagatg acaaaggctt atacgacatt cggaaacagc 2886541 ggaagctata cgccgagcca tgcgattaca aaggtgacag accttaaagg aaaaacactt 2886601 tataaatgga atgataaagc gactcaaata ttcagcgtcc gcacgaacat gcagctgaaa 2886661 aaactgatgt cttccgttgt gaaaagcgga acagggaaaa aagcatattt caatgcgcct 2886721 tacatcggcg gtaaaaccgg aacatcaaat gattatcacg atatgtggtt tgtcggcctg 2886781 actgatacgt atacaatggg tgtctgggtc ggaaaggata caccgaccag cgttgaatat 2886841 cttcacagca tcagccctca gctttccatc tggaaaggaa cgctgcaagc ggcttattaa 2886901 aggatcggag gggatatgga gtgacttcag aacaaattcc aaatcgcgtt ttgctgtttg 2886961 acggtgtctg caatttatgc aatggcgccg tgcagtttat cattaaacgt gatccggacg 2887021 gattgatttc tttcacatcg ctgcagtcgg aaacaggaca gagcctgctg aaaaaaagcg 2887081 ggcttccgac tgatcggttt gacagctttg tctttattga agacggccaa gtgtacacaa 2887141 agtcaactgc agccattaag gttttcaggc atctgcgagg cccatggcgg ctcttcgtcc 2887201 tttttttcgc agtgccgaag cctgtcagag atatggtcta ttctttcatt gccaaaaacc 2887261 gctataagtg gtttggcaaa aaaaatgaat gtatgctccc ctccccttcc attaaaaaaa 2887321 gatttttacc gtaaataaaa aatggctagg aagctagcca tcacagattg ttgacaaaat 2887381 cctaaaacgg cttcgtttta ggattttgtc atctattcag cgtgattgaa aacttttgaa 2887441 gttgtgaaac ggcggaaacc tgagaatcta gccgccgttt cattgcgtac agagcacgaa 2887501 gcgcaaatct gaccaccaaa cgctgaaatg gctagcttac acaggtaagc tagccattat 2887561 gctattataa agcttgataa atatgaacag aataccgata acaaaggtaa accaaaacag 2887621 cagttccaat agaatgaatc caactaatga catgagagaa agcgtcgaat aaatccggta 2887681 tacggtaaac acaaagtaag cgagcgtgac gaccgcaaac cagatcacaa tccaaatgac 2887741 attttgcaag agcacaaagg ataaaatccc gccgcccaaa taaatcatgg aacccattct 2887801 gagttttttc aggttgttcc cttccggatc attagcaaaa aacagcaatg acagctcggt 2887861 cacggtattt gcaattaatt tcagagcgga cagaaccata aaatataaaa gtgcaaaggc 2887921 agcaaataac gcaagcctga ttcctttctc tgaaaaataa tcgagcattc catcatacat 2887981 tccaaatgaa gacagcatct tcaacgcata aagtgaagtt gagatggata aggacgaact 2888041 aaaaagcagg atcgcaatca gcggaaaata tcctgtcaaa taagtatttt tcatataaaa 2888101 aagtcccttt ctataatcta cctcatttat tatggaggac ttaaaacaca ttgacaagat 2888161 aaattattcc attttttctc ctttttacga attacgggcc caaatcttca caaagcagca 2888221 ttttgagagt aaagtagtac gcaggaatca taaaacgtaa ggaagtttta tatgaaaaaa 2888281 acattaaaac tgcaaaccag actcaccata tttgtttgta tcgttgtatt aatcgcattg 2888341 ctcattacgt tttttacagt cggtgcccaa accaccaaac gaattagaga tcaggaaaag 2888401 gccactgcgc tgcagactgc tgaaatggta gctgaagcgc cgatgacagc cgctgcttta 2888461 gaaagcggaa aaaaacaaaa ggaactgcag agctacacaa agcgggttca gaaaattacc 2888521 ggcacggaat ttgttgtcgt catggatatg aacggtatcc gcaaaactca tcctgacccg 2888581 agcaaaatcg gaaaaaaatt cagaggcggt gatgagtccg aggtattaaa agggcatgtc 2888641 catatcagca cagcctctgg cacgctcggg aaatcgcaga gagcgttcgt ccctgtctac 2888701 gcggagaatg gaaaacaggt cggtgcagtc gcggtcggca tcaccgtaaa tgaaattgat 2888761 gaagtgatca gccatagctt acggccgctt tactttatta tttgcgtcag catcttcgtc 2888821 ggtgtgatcg gagccgttat cgtcgcccgt acagtgaaaa atatcatgta cggacttgaa 2888881 ccttatgaaa ttgcgactct gcttgaagaa cggagcgcga tgctggaatc gacgaaggaa 2888941 ggaatactcg ctgtcgatga acatggcaaa attaaacttg ccaacgcgga agcaaaacgc 2889001 ctattcgtca aaatgggcat caacacaaat cccattgatc aggatgtaga tgacatcttg 2889061 ccgaaaagcc gcttgaaaaa ggtcattgag acaaaaaaac ctcttcaaga cagagacgtc 2889121 cgcattaacg ggctggagct tgtgtttaat gaagttccta tccagctgaa aggacaaact 2889181 gtcggagcga ttgcaacatt ccgcgacaag accgaggtaa aacatttagc tgaacagctt 2889241 tccggtgtta aaatgtatgc aaacgcactg agagcgcagt ctcatgaatt tatgaacaaa 2889301 ctgcatgtga tattaggtct cgtccagctg aaagagtatg atgatcttgg agattatatt 2889361 aaagatatag ccatacagca aaaatcagaa acaagtgaaa ttataaatga tgtcaaaagc 2889421 tccgtactgg ccggttttct gcttggaaag caaagcttta tacgtgagca gggcgcaaat 2889481 cttgatattg aatgcaacgg tgtcatcccg aacgcggcag acccttctgt catccatgaa 2889541 cttattacaa tcatcggaaa tctcatcaac aatggcttag atgccgttgc cgatatgccg 2889601 aaaaaacaaa tcaccatgtc catgcgcttc cataacagca tacttgatat tgaaattacc 2889661 gatactggag caggcatgtc tgaagaagac caagccaaag tatttgaaca aggctattca 2889721 acaaagggca aaaaccgggg attcggcctt tatttcacac agcaaagcat cgaaaattta 2889781 aaaggccaaa tgatcctcac aagcgaaaag aatgaaggaa cgacattcag tattcgcatc 2889841 ccgtacgaac cgaaggagga aaatcatgat taatgtacta atagttgaag atgaccccat 2889901 ggtgggtgaa ttaaataaac gatacttaag ccaaatagat ggctttcagc tgaaaggcat 2889961 cgcttcttcc tttcaaagcg ctctgcatat tttaggggag caccatattg acctcatttt 2890021 gcttgatatt tatatgccgg gaaaaaacgg gctggaactg ctgacggaat tgagagccca 2890081 aaatgaagcg gttgacgtga ttgtcatctc agcggccagc gagcttgacg tgatcaagaa 2890141 aacacttcgg tacggagctg ttgattattt aatcaaaccg tttgaatttg aacgattcca 2890201 aacggctctg tctgattaca gacgaaaaca aaaggtgtat tcaacccatc gcaacatgag 2890261 ccaaaaagaa ctggacgccg agctttttca aaagaaagaa gcaacagaaa aagtgcagct 2890321 tcctaaaggc ctgacaaaaa gcacgctgaa gctgatctgg tccagtatcc agtcatttga 2890381 aaatgaatct tttacgacag aagacttggc aaagcacaca gaaatctctc aagtatccat 2890441 acgaaaatac ttaaagtttc ttgaagatat acaggttctg aatgtagaaa tggcgtacgg 2890501 aacgatcgga agacctgtgt ttcagtacaa cgtcaacaac agtaacatta acggaataaa 2890561 gcaatatcta taagaaaacg cactgcttgc tttgagcagt gcgtttttct gtcatatctc 2890621 ttgccaagat gcttgattct attgttgata agttatacaa gaataacaaa gggctttcac 2890681 atttttaagc aaataattct aaaaatagat aatttttaaa aaattatgcg aaattctatt 2890741 tatttcttat tagttaaatg ataaattatg attggttagt tgatcccgaa aaactaagtc 2890801 ataagtctta cttcagaaaa cgatgtcacg gttttccgcc cggaacgcct tccgcatcct 2890861 tctcttcccc gcctttcgaa ggaaatactc acaccacgct tattcaggga agaatagaac 2890921 tgtctcagcg cattccattt gttattatca gaaaatttta tcgattctaa gaaattgttc 2890981 aggacagccc atcacatgac tggccggatc agctttgaac caaatttttc tggggggtta 2891041 tatcttgaat aaacgaaaaa tcggattggc gatgtcactt gtgatcgcag caggcaccat 2891101 attaggagca tgcggaaaca gcgaaaaaag cagcggctca ggcgaaggca aaaacaaatt 2891161 cagtgtggcg atggttactg acgtaggcgg agtggatgac aaatccttca accaatcagc 2891221 ctgggaaggc atccaagcct ttgggaaaga gaatgggctg aaaaaaggca aaaacggtta 2891281 cgactatctt caatccaaat ctgatgcaga ctatacaacg aacttaaata aattggcgcg 2891341 tgagaatttt gacttaattt acggcgtcgg ctacttaatg gaggattcaa tcagcgaaat 2891401 tgctgaccag cgtaaaaata caaactttgc gattatagat gctgttgtcg ataaagacaa 2891461 cgtcgcaagt attacgttta aagagcagga aggctcattt ctcgtcggag tggccgcagc 2891521 cctatcaagc aaatcaggaa aaatcggctt tgtaggcggc atggaatcag agttgatcaa 2891581 aaaattcgag gtcggcttcc gtgccggcgt gcaagcagtt aaccctaaag ccgttgtaga 2891641 agtgaaatac gcagggggtt tcgataaagc cgatgtcggt aaagcaaccg ccgaaagcat 2891701 gtataaatca ggcgtagatg ttatttatca ctctgcgggc gccactggca caggcgtctt 2891761 tactgaagcg aaaaacctga aaaaagaaga tccaaaacgc gatgtctggg tcatcggtgt 2891821 cgataaagac caatacgcag aaggccaggt agaaggaaca gatgataacg tcaccctcac 2891881 ttccatggtg aaaaaagtag atacagtcgt tgaagatgta acgaaaaaag cgagtgacgg 2891941 aaagttcccg ggcggcgaaa cacttaccta cgggcttgat caagacggag tcggcatttc 2892001 tccatctaaa caaaatctat cggatgatgt gatcaaagcg gtcgataaat ggaagaaaaa 2892061 aatcatcgac ggattggaaa tcccggcaac tgagaaagag ctgaaaacct tcaaagctga 2892121 ataagaatcg cagggataag gaggtcgagc ccttatccct tgtttttctt ttattttgaa 2892181 ataaaggagc ggtcaatcaa tggaatatgt cattgaaatg ctcaatatcc gcaaggcgtt 2892241 tccaggtatc gtcgccaatg acaatatcaa tcttcaagtc aaaaaaggcg aaatacacgc 2892301 gttgctcggt gaaaacggag cggggaaatc aacattgatg aatgtccttt tcgggctgta 2892361 tcagccggag cggggtgaaa ttcgggtgcg cggcgagaag gtgcacatca acagcccgaa 2892421 caaagcgaat gaccttggaa ttggaatggt gcaccagcac tttatgcttg ttgacacctt 2892481 tacagttgct gaaaatatta ttctcgggaa ggagccaaag aagtttggca gaattgaccg 2892541 gaagcgtgct ggccaagagg tgcaggacat ttccgatcga tacggcctgc agatccatcc 2892601 tgaagcaaaa gcagctgaca tatcagtcgg tatgcagcag cgcgcagaaa tattaaaaac 2892661 cctctaccgc ggtgccgaca ttctgatttt tgatgaaccg acggctgttt tgacgcctca 2892721 tgaaattaag gaactgatgc aaattatgaa gaacctggtc aaagaaggga agtccatcat 2892781 cttaatcacc cataagctga aagagattat ggagatttgt gaccgcgtta cggttatccg 2892841 taaaggaaaa ggcatcaaaa cccttgatgt ccgtgataca aaccaagacg aactcgccag 2892901 tctaatggtc ggccgtgagg tatcgttcaa aactgaaaag agagctgctc agccgggagc 2892961 ggaagtgctt gcgattgacg gcataactgt aaaggatacc cgcggaatag agacagtcag 2893021 agatttgtct ctttctgtca aagcgggaga aatagtcggc atagcaggcg tcgacggaaa 2893081 cgggcaatct gagctgatcg aagcggtgac aggactccgc aaaacagatt caggaacaat 2893141 caccttaaac ggaaaacaga tccaaaacct gacgccaaga aaaatcactg aatccgggat 2893201 cgggcatatt cctcaggatc gccataaaca cggtctcgtc cttgattttc caatcggaga 2893261 gaatatcctg ctgcaaagct attacaaaaa gccgtattca gcattgggcg ttttacataa 2893321 aggcgaaatg tacaaaaaag cacgcagcct gatcactgag tacgatgtca gaacgccgga 2893381 tgaatataca cacgctcggg cattgtcagg cggaaaccag caaaaagcga ttatcgggcg 2893441 ggaaatagac cgaaatcctg atttattaat tgccgcccag ccgactcgcg gccttgatgt 2893501 cggagcgatt gaatttgtcc ataaaaagct cattgagcag cgtgatgccg ggaaagccgt 2893561 tcttctcctc tcgtttgagc ttgaagaaat tatgaatctc agtgacagaa tcgccgttat 2893621 ttttgaagga cgcattatcg ccagcgttaa tccgcaggaa accactgaac aggagcttgg 2893681 tctcttgatg gcaggaagca cgcaaaagga agcggggaaa gcaaatggtt aaacgactct 2893741 ctcatttact cgtgccgctc atcgcaatca tacttggtct tgcggccggc gcgttgatta 2893801 tgcttgtgag cggctacagt gtggctagcg gatattcggc tttgtggaat gggatattcg 2893861 gagaaatcta ttatgtcgga gaaacaatcc ggcaaattac gccttatatt ttatccggat 2893921 tggctgtcgc ctttgcattc cgaaccggac tctttaatat cggcgtcgag ggacagctgc 2893981 tcgtcggctg gacagcagcg gtttgggtcg gtacggcgtt tgacggaccg gcatatattc 2894041 acttgccgct cgcattgatt acagcggcag ctgcaggagg attatggggg tttattcccg 2894101 gcattttgaa agcgcgattt tacgttcatg aagtcattgt caccattatg atgaattata 2894161 tcgcgctgca catgaccaat tacatcattt caaacgtctt gacagatcat caggacaaga 2894221 cggggaaaat tcacgaatcc gcctccctcc gctctccttt tcttgaacag atcaccgatt 2894281 actcacggct gcatttggga atcatcgttg cccttctcgc agcagttatc atgtggttta 2894341 tcatcaacaa atctacaaaa ggatttgagc tccgggcggt cgggtttaac cagcacgctt 2894401 cccagtatgc cggcatgagc gtgcggaaga atatcatgac ctccatgctt atctccggcg 2894461 cttttgcagg tcttgccgga gccatggagg gcctagggac attcgaatac gcagcagtga 2894521 aaggcgcatt taccggcgta ggctttgacg gtatcgctgt cgctcttctc gggggaaaca 2894581 cagccgtagg cgttgtactg gcagcatgcc tgcttggcgg gctgaaaatc ggcgcattaa 2894641 atatgccgat tgaatcaggc gttccatcag aggtcgttga tattgtgatt gccattatta 2894701 ttctatttgt ggcttcaagc tatgcgattc gtttcgtcat gggcaaattg aagaaaaagg 2894761 gggcgaacta agtggacatt gtgcagattt tatctatcat tgtccctgcc acactcgtct 2894821 atgcggcccc gcttatttta actgctctcg gcggcgtgtt ttccgagaga tcaggtgtgg 2894881 tgaatatcgg cctagaaggc ctcatgatta tcggggcgtt caccagcgtg ttatttaatt 2894941 tattttttgg tcaggaatta ggtgccgccg caccttggct ttcgctcctt gccgccatgg 2895001 cagcaggcgc cctgttttca ctgattcacg cggcagcggc gatttcgttt cgcgccgacc 2895061 agacagtcag cggtgtcgcc attaacatgc tggcgcttgg ggcaacttta tttatcgtca 2895121 aactgatcta cggcaaagcg cagacagaca aaattccaga gcctttttat aagacgaaaa 2895181 tccccggttt gggcgatatt cccgtcttgg gaaagatctt cttttcggat gtctattata 2895241 cgtctattct tgcaatagca cttgccttta tttcctggtt tatcttgttc aaaacgccgt 2895301 tcggccttcg tatccgttct gtcggcgagc atccgatggc ggccgatacg atgggaatca 2895361 acgtatataa aatgcgctac atcggcgtga tgatcagcgg attgttcggc ggtctcggcg 2895421 gcggcgtata tgcctccaca attgcgcttg atttcacgca ctctaccatc tccgggcaag 2895481 gttttatcgc cctggcagcg cttgtattcg gaaaatggca tccgatcgga gcactggggg 2895541 ccgccctgtt tttcggattc gcccaaagct taagcatcat tggatcgctg ctccctcttt 2895601 ttaaagacat accaaatgtg tatatgctga tggctcctta tatcttaacg attctcgctt 2895661 taaccggctt tatcgggcgg gcagatgcgc caaaagccaa tggcgtgcct tatattaaag 2895721 gaaaaagata aacattctcc cctgggaaga cgattctcag ggattttttt ctaatccaaa 2895781 agaccccctt aatttaattg tttattagtt ttttaactta aaaaaatatg aagtgttaac 2895841 gctttcttgt agactgtaac aaacaataca tgggggtgta tgacatggga gcaattccaa 2895901 aaacggggac aatttcacct gagcaaaaag actcacagga gaaaaacctg tttcaaaaaa 2895961 tttggtcttg ggaaatcggt gtgattcctt tgccattata cacagtatta gctgttatta 2896021 ttattcttgc agcatattac aatgagctgc cggcaaatat gcttggcggg tttgccatca 2896081 ttatgattct tggtgtgttt ctcggagaca taggccaacg cataccgata ttgaaggata 2896141 ttggcggccc tgctatttta tctttgtttg ttccttcatt tttagtcttt tacaatgtac 2896201 tgaattcaac atctttagac gctgtaacca acttgatgaa aacgtctaac ttcctttatt 2896261 tctatatcgc ttgccttgtt gtgggaagta tcctcggtat gaacagaatt gttttaatac 2896321 aggggtttat cagaatgttc gttccactgg ttgcaggaac gatcgcggcc gttgcagccg 2896381 gcatccttgt cggatttatt tttggctata gtgcctatga ttcctttttc tttgttgttg 2896441 tcccgattat tgccggggga ataggtgaag ggattttgcc gctttcaatc gcctattcac 2896501 aaatactggg ctcatccgcc gatgtatttg tgtctcagct ggtgccagcc gcaattatag 2896561 gaaacgtttt tgctatcata tgtgcagcct taatgaaaaa gcttggcgac aagcgtccag 2896621 atctaaatgg gaacggacgt ctcgtaaaat ctaaaaaagc aaatgagatt ttcaatcaaa 2896681 aagaagccga agcaaaaatt gattttaaac taatgggagc aggagttctg ctcgcgtgta 2896741 cattctttat ttttggcggg ttattggaga aattcatctt catcccgggc gcgatcttaa 2896801 tgattatttc agctgcggct gtcaagtatg caaatattct tccgaaaaaa atggaagaag 2896861 gcgcttacca gctttataag tttatttctt caagctttac atggccgctg atggtcggtc 2896921 tcggcatcct ctttattccg ttggatgacg tagcgtctgt gatttctata ccgtttgtca 2896981 tcatctgtat ttcagttgtt atcgcgatga ttggttctgg atatttcgta ggcaagctga 2897041 tgaacatgta tccggttgaa tccgcaatcg ttacctgctg ccacagcggt ctcggcggaa 2897101 cgggtgatgt tgccatttta tcggcatcag gaagaatggg ccttatgccg tttgcccaaa 2897161 tttcaacccg tctcggcggt gcaggcacag ttatttgcgc gacagtgctg cttcgttttt 2897221 tcacttcata aacagaaaga gttccgtttt atgcggaact ctttttttat ttattcacaa 2897281 tccgaatata ctctcgggga ccaaacggca gatcctttga ttccgtctca ctcattctgg 2897341 ctgacaggtg gtgctccagt aaatacagct cccactcatc acaagccgcc acaccgctgc 2897401 gcccgtcata ttgattcaac atgaatgccc ctgcaaatac tgagcagaat aaacctgagc 2897461 acatcacgac ttttgttttc acatgaccag ctcctttcct tcagcttgat caggattgat 2897521 tttaaatata caaataacct cttttttgtt agacttattt tgaggtcaaa agaactcata 2897581 aaaatccatt acagcagttc gaagcgtggc agcttgcaga aaagtgcgat ataatttgga 2897641 ctaggtcgtt tgaccgtata ttttatacat agcgcatttt tcaattgaga acgagaaaag 2897701 gaggtcttat ctttgcagct cttacatctt gctattttat cgcctttttt atttgctttt 2897761 atcattccct tcttggcaaa atacgcaaaa agagtgcata cgggctggtt tgtgttgatc 2897821 ctgcccgtct tgctgtttat atactttctc ccaatgatca ggatgacgca atctggagaa 2897881 acacttcgat cggtattaga gtggattccg tcactcggca ttaactttac cgtttatata 2897941 gacggcctcg ggttattatt cgctttactg atcacaggca ttggctcttt ggtcactctt 2898001 tacagcattt tttatttatc gaaagaaaaa gaacagcttg ggccctttta tgtctactta 2898061 ttgatgttca tgggcgccat gctcggcgtc gttctagtag acaatgtcat ggttctctac 2898121 atgttctggg agcttacaag cctttcatcc tttttgctga tcggctattg gtataagcgg 2898181 gaaaagtcgc gctatggcgc agccaaatca cttttgatta cggtcagcgg cgggctgtgc 2898241 atgctcggcg gatttattct cctttatttg ataacggatt ccttcagtat tcgagagatg 2898301 gttcaccagg ttcaattaat tgccggccac gaattgttta tcccggctat gattctcatt 2898361 ttattagggg cttttacgaa atcggcgcaa tttccttttt acatctggct ccctgacgcg 2898421 atggaagctc cgacgcctgt cagcgcttat ctccattcag ctactatggt aaaagccggc 2898481 atttatgtga ttgcgagatt cagtcctatt ttcgcctttt cagctcagtg gttttggatc 2898541 gtgtccctcg tcggcctctt tacgatggtt tggggttcat tccatgccgt gaaacaaact 2898601 gatttaaaat cgattttggc gttttcaacc gtcagccagc tcggcatgat catctccatg 2898661 ctcggagtca gtgctgcggc ccttcattac ggacatacag aatattatac agttgccgct 2898721 atggctgcca ttttccattt gatcaaccac gcaaccttta aaggaagctt gtttatggca 2898781 gtcgggatta tcgatcacga aacaggcaca cgggatatcc ggaagctagg cggcctgatg 2898841 gcgattatgc cgattacttt taccatttcc ttaatcggga cattttcaat ggccggccta 2898901 ccgccgttta acggattttt gagtaaagaa atgtttttca caagcatgct tcgcgtgaca 2898961 cattttgacc tgttcaacgt gcagacatgg ggcgttctgt tccctctttt cgcctggatc 2899021 ggaagtgtat ttacgtttat ctacagcatg aaattgctgt ttaaaacatt cagaggaaat 2899081 taccagcctg aacagcttga aaaacaggct cacgaagcgc ctgtcggtat gctcgttcca 2899141 ccggtcattc ttgtcgcttt ggctgtcagt ctcttctttt tcccgaatat attgtcgtac 2899201 agcctgatag agcctgcgat gaactcaatc tatccgacac tgcttgacgg ccatgagaaa 2899261 ttccacgttc acatttcaca gtggcatggg gttacaacgg aattgctcat gactgcgggt 2899321 attgttgtga tcggaacaat tggttatttg tcgctgaata agtggaaagg aatctataaa 2899381 ctgtttcctt cgaaactcac actcaaccgg ttatacgata agcttttgac tatgatggag 2899441 aaaggctctt accgggtcac aaaacaatat atgaccgggt ttttaagaga ttatttgctg 2899501 tatatcttcg ctggtttcat cattctgata ggcggagctt ttgccattaa aggcggattt 2899561 tcatttaaaa cggaaggcat ggctaaaatc ggtgtatacg aaatcatttt gacgcttgtc 2899621 atgatcagcg ccacagtggc gactgttttt gctaggtcaa gactgacggc gatcattgca 2899681 ctcggtgttg tcggttatac gcttgcattg ttttttgtca ttttcagagc gccggacttg 2899741 gcattgactc agctcgtcat tgaaacgatt tctgtggcac tgtttctgct ttgcttctac 2899801 catttgccga aactgaggct gaaaacaaaa acgagaacgt tccggatgac gaattttatc 2899861 atttctttag gcgtcggtgt tatcgttaca ctgctcggca tcgcatcctc aagccagcgg 2899921 acaaaagaca gcattgcgtc cttctttgtc aaacacagcc acgatctcgg cggaggggat 2899981 aatgtcgtca atgtcattct cgttgatttc aggggatttg atacaatgtt tgaaattacg 2900041 gtattaacga tagccgctct cggcatttac agcatgatta aaacaaaagt aaaagaggag 2900101 gggaaaagcg gtgaatgaac aaaaaacaaa tgacttgatt cttcaaaccg cgacaaagct 2900161 tgtatccttt atcattttgc ttttctcttt ctatttattt ttatcagggc ataacgcgcc 2900221 cggaggaggc tttgtcggcg gactgatcac gtcctcttcc atcgttctct tgctcttggc 2900281 atatgattta aaaaccgtgc gttccctttt gcctgtcaat ttcatttatg tcgcgggagc 2900341 cggccttctg ctcgctgtat taacaggcgt tggctccttt gtcttcgggg ctcctttttt 2900401 aacccacaca ttcggatact ttcagctgcc gatccttggg aaaacggagc tcgccacagc 2900461 gacgatattt gatttaggcg tttatcttgt tgtcgtaggc ataacgatga ccattattca 2900521 aacgattgga gaggaagaat aatggaaatc ttaatggctg tattagccgg tattattttt 2900581 atggctgcta cgtatttgct gctgtctaaa agcctgcttc gcgtcattat cggaacagca 2900641 ctgttaagcc atggcgttca tttaatgctt ttgactatgg gaggattaaa gaaaggcgcc 2900701 gctccgattt tgagcgagca tgccaaatca tttgtcgatc cgcttccgca agccctgatt 2900761 ttgaccgcaa ttgtcatttc ttttggcgtt acgtcattca tcctcgtcat ggcctttcgc 2900821 gcttatcagg aattgaaatc ggacgatatg gatcaaatga ggggaaatga tcaacatgaa 2900881 taattttgtt attttgccaa tcctgatccc gcttttgtcg gctattcttc tgattttcat 2900941 gacgaagaat cttatgctca tgagaatctt cagcacggcg gcatcggcca tcgggattgt 2901001 gattagcggc atacttgtac agactgtctt cacaaaaggc atccagacac tcagcctagg 2901061 cggatggaaa gcgccgtacg gcattgtgct tgccgcagac caattcgcca gccttctcgt 2901121 tctcacaaca gcgatcatcg gtttattggt tgggctttat tccttccgtt ctgtcggtga 2901181 aaaacgggag cgctcctttt actactccgg cgttcagttc ttgcttgccg gcgtcagcgg 2901241 agcgttttta acaggcgatt tatttaatat gtacgtattt tttgagcttc tgcttattgc 2901301 ttcctatatg ctgattgtat taggcggcac aaaaattcag ctgcgggaat cccttaaata 2901361 tattgtgttt aatattgtat cgtctgccct gtttgtcata ggggtcggct ttttatacgc 2901421 tgtaaccggt acgttaaaca tggcggatct tagcgtgaaa atcagcgaat caggacaaac 2901481 cgggctgatc actgtgattg gtgtcctgct gcttttggta tttggcatga agggcggaat 2901541 cttccccctc tacttttggc ttccaggctc ttattacgcg ccaccggcgg caatctccgc 2901601 gttgttcggc gctttgctga caaaagtcgg gttatatgcg attacgaggg ttttcacatt 2901661 gatttttatt cacgatacag cctttaccca tcagttgatg atttggctgg cggcgctgac 2901721 tgtgattttt ggtgtgatcg gttcactcgc ttattcgaat gtcatgaaaa ttgtgatcta 2901781 taacattatt accgctgtcg gcgtgatttt gttcggtgtg gcagtacaca cccccgcatc 2901841 cattcagggc gcgatctact atctgattca cgatatgctg attaagggcg ctttgttcat 2901901 gctggcaggt acgctgatcg cattgactgg aaccgcgagc ctgcataaaa tgggcgggct 2901961 gatcaaacgc tatcctgttc ttggatggat gtttttcatt tccgctattt ctcttgcagg 2902021 cattccgcca ctgagcggat ttgtcggcaa atttaaaatt gcagagggcg gcttcgcaga 2902081 aggtgaattt acgatatcca tgctgattct gctttcgagt ctgcttgtac tgtactctgt 2902141 gctgaggatc tttatacatg cgttttgggg cgaagaaaaa gaaacgccaa aaccaaatca 2902201 tcgaacagct aaaggacttc tttatccggc agctattttt ctcttgctgt cccttctctt 2902261 cggattgggt acagaatggg tgtcgcctta cgttgatcaa gcggccgaga cgctgctgaa 2902321 tccggaaaaa tatatcgaag ctgttctgaa ggagtagatc gcatggcatt tcaaatttta 2902381 ttaaatgtgt ttctcgcttt ttgctggatg ttcttaagca acagtccaag cgccgcagga 2902441 ttcattacag gctatattct gggaatgctc tctctctttt tcttccggcg ctttttcact 2902501 cgccagtttt atctatggaa attgatttct attatcaagc tctgtttcat ttttataaag 2902561 gaactgtacc ttgccaatgt cagtgtgatg aaatcagtct tatctccaaa actgaatatc 2902621 agaccgggta tttttgcttt taaaactgaa ctgacgaagg actgggaaat caccatgctt 2902681 tctctgctca ttacattaac gccgggaacc ttggtgatgg atatttcaga tgacagaaca 2902741 atactttata ttcatgcaat ggatatcgag gatgcggaaa aagcgatttt tgacattcgg 2902801 gagtcatttg aaaaagccat acaggaggtg agccggtgat gtttacgctg atcctgcaaa 2902861 tcgcgctcgg cattatggca gtgtctacct ttttgtatgt cattcgtgtc attaaaggtc 2902921 cgactgtgcc tgaccgggtc gtggctctgg atgcaatcgg catcaatctg atcgcaatca 2902981 cggcgcttgt ctccattttg ctgaaaacaa gtgcgttttt ggatattatt ttgttgctgg 2903041 ggattttatc gtttatcgga acgatcgcat tttccaagtt cctggagaaa ggagagatta 2903101 tcgaaaatga tcgaaaccgc taaggtcgtt gtggctgtat tcattttgct gggtgctctt 2903161 atatgcctca ttgcttcatt tggcgtactt cgccttcccg atgtgtttac acgcgctcat 2903221 gctgcttcta aaggctcaac attaggtgtc aatatgattc tgctcggtgt cttcttctat 2903281 ttgtggtttg tgacggggga gctctccgct aaaatcctgc ttgggattct ctttatcttt 2903341 attacgtcgc ctatcggcgg gcacttgatc tgccgtgctg cgtataactc cggcgtcaag 2903401 cttgatgaga gaagtgtgca agatgactat aacggaatca gaaactttgt gattaaacga 2903461 aaagaggatt cttatttata aaaataagca gccggacagg cagagttccg gctgtttttt 2903521 tatttcttga tgacagccag cgtgcatctg gatatacaga tcagcctctc ttgctcgtca 2903581 tatatgtgaa tatgatagac aatcgtcgtt ctgcctatat gaacgggctc ggctatcgcc 2903641 tttaccgttc cttcctttac agattttaaa tggttggcgt taatctccaa accaacacaa 2903701 gcttgcgttg tatgatcaat caggttctgt gcacctgcgc tcgccgcggt ttccgccagg 2903761 gccactgaag cgcctccatg caaatatccg aacggctgta ccgtccgatg atccaccggc 2903821 atgaccgcaa cgcatcgttc cgctgtgttt tcaacaatct caataccaag cgcttcaagc 2903881 aatgtgtgct tcatatccat ctctacaccc cccaacattt aaagtacacc gtctgatttc 2903941 gcaatcaaaa ccgcttccgt ccgtgaaccg acattcagct tattgaaaat cgatgtcaag 2904001 ctgtattcaa tggaccgctt gcttaaatga agggcatctg cgatttcttg gtttgtaaat 2904061 cccttttcaa cttcttgaag aatcaggcat tctctaggtg tgagcacatc ttgttctttt 2904121 tgagaggaag gagccggctt tgttttttgc tgagtcatca gctgtttaaa gtaagcaaaa 2904181 tcgactaaaa tttctccgtt gagtacgtgg tatatgtatt gggtgatctt ttctttagat 2904241 tccgttttgc tgatggcacc gtgcagaccc gcacgaatcg cttcctcgaa ataatcctcg 2904301 acctcataac cggtatacac gataatttta caatgaggat tctcttgtaa aatctgttta 2904361 gaaagctcca tcccattgac ctcgccgcct agattcagat ccattaaaat gagatcatat 2904421 gacgagaaat catgctgctt gataaactgt tcgctcggtt caggactgag acaatcaaca 2904481 gacaaattcg aatccgtttc caaaattgtc ttggtgcctt ccatgacagc cggatggtca 2904541 tcaatcacta gtatcttttt catgttttcc tcccttttac tcactctttt ccattttata 2904601 aaaaagactt ggcctgtgcc aagtcgtttc cgttataaat ccattacaat tcgatttcaa 2904661 tatcagcctt aaagcccttt ccttcacttg tttcaatccg aaggcgccca tctaaagccc 2904721 tgactctctc cttaatgcca gaaagcccca tgctcatgga atgctcagta tttttttctt 2904781 gatcaaaccc aacgccatcg tcctcataat gaagaacgat tttgttttga atactgatga 2904841 gcataatcag cacatccgtc gcctgagagt gcttgaccgc attagacaga aactcttgaa 2904901 tgatccggta caaattcagc tgcgaatcca gatcaaggga agccgtaaat ctcccggtat 2904961 ttaaacggat atgaaacgga acccgctcct gctgctgcgc caccagcttc gacagcgcct 2905021 tcaccaatcc aagatcatac agaagctgcg gccgcagctc atgacacgtc tccctcgtca 2905081 tcgaaatcac atcagacatc tgctcattca tctgtacaag cttgtcctgc acctcttcac 2905141 ggcacggatt atcatccttc ttgaaatcac ccaaaaacag ctcacactgg cgttttaagg 2905201 aaatcaaatc ctgaagaacc gaatcgtgga gatcgcgggc gagtcctgaa cgctgttttt 2905261 cttcgattgc aaacattagc tttttcagcc agatggggtt ggttccctct tgttttaagt 2905321 ccttcaaatg ttccatgagc tcctcaatat gcaggacatt ttccatggac acacttgtat 2905381 aaaaagacag tgttttcagc cacgatattt catcacgtgt tagccgggga gtgttaatat 2905441 tagataaaca aagcagaaca taagaactac cgcctcgttc accaactttc ataagaaagc 2905501 cttgattgac ttctataatt ttcccaattt ctgaagttac gttttcaaat tcctcttgat 2905561 aaaaattcca gtccggtcca acttcatgct tatctaaaaa tatcactttg tgatcaggag 2905621 taacctcaaa ggtataagct ttgcttacaa gcaaaacatc cagtatagta tttttcagtt 2905681 ctttaaaaac ttgttgaaga gaagttacac ccctcattag ctgagtatat ttaaaaatac 2905741 tgtcctgata gttgaatttt tcggagaaac gttttaaccg aaatttaaaa tccatgacct 2905801 ctttaaaata aaagacagcg aacatgacaa cgaaaaaaaa tacagtttga cgcacagggt 2905861 tcatctggat gtccattaca tcaaacagaa ctaatgcacc aactattaga agagttggta 2905921 tcatggcaag tagagcatag tatctcattc ttcctaagat aaactctata tcaaacatct 2905981 tattggctac aaattggtat actaacccga acggaattag tactagtaat gacgccgaag 2906041 ctaatgccgg gaaaatataa ttacctgtaa atattattgg aagaacaaaa aatatcaaaa 2906101 aaggcgcaaa tgaaagagtg tttgttaaaa ttagtaattt aagaataaac gaatgctcag 2906161 catatttata tttattaaga tgtaagtata tcgctgaaaa agaaaataga gtcaaagttg 2906221 caaaagaaac caaattaaga gttgctaaaa aatcaatatc tacttgtaaa tagtcttgaa 2906281 aaaactcaat accaagatta aatattggta tgatataaag aaaagaaatt ctattcaaaa 2906341 aagttttacc tatttctcca aggtatcttt gtataaattg aagataaaga ataggagaag 2906401 atataaaagt aaacaagtta atataccgat tgattatatg tcctctaaat ggtccgcctg 2906461 cacttatata tgctatcgaa atgtctaata acaatagaat aagaatatag gcagcaaatg 2906521 atctcctttt tttatttact ttaagtatat aaaaaataca tattatgctt aaaaaataaa 2906581 aaaacaaagg aagtacgaac agaaaaaaac tataaggtct atttagagta actaaatcaa 2906641 aatctttgag atgaatcttt tttccacttc tcaaaatatc cagactgtta atatgactca 2906701 aatatcccca tttcaaatgt ttgtctgaag gtttttcttt attaattttt aatatgatgt 2906761 ctccctgtct cagaccaaca aattgtccat atgaagattc cgatatttct tctatcataa 2906821 attgactttt atcattttta tgaatcttag tcccaataat aattccattc atactgatat 2906881 aagttgtata gcttatataa aggatactca aaacaattac agctattgtg aattttttta 2906941 ttaagttctt caatattaat ccacctatta atcaccccat tgacgggtta ttggatcagc 2907001 cagataataa tcattataag ctttaattat tgtttcagtt tcttgcacat caaaacctat 2907061 aaggcaggct tctttatttt tcaatttttt taaagcctca ggataattta aaaagtagtt 2907121 aattaggtct tgcatcttgt atcccccttt gtataactta ataagcattc ctttattagc 2907181 tctttttttc tttatctaaa tttaattgtt ctatagcaga aatacatttc tgtttatata 2907241 tttccaataa taccgaaatg tattgagtaa ctcccgcttt aattaatttt tcttggaatt 2907301 tctctttatc aagtaacgat ttataatata agtctttatg tgaaattaag tataataaat 2907361 cttccgaagc atcattaaaa aggcgcttaa gatataagta aatcagtgta tgtttgtttt 2907421 tttcaatatc actgcgattt ccggataaaa gaacataata atctccagaa atttgagcta 2907481 taatcccttt atagtaggaa tatctttcaa ctgtttcatt atattctcct gtagccaata 2907541 aaacacctgc tacatttgct agtgcaatca gacttccaca ttttaatcta attacttcta 2907601 aactttcatc ttctgtttta gatttattag tgatatcgtc atgttgacct tgcatggcct 2907661 cgtttacgta ttttaaaaca tatttaaaaa ttagaggatt gttatttaat gaataaatac 2907721 tcgttaatcc tactgtatac aaggaaagtg ctgcatttaa cgactccgag cgattaattt 2907781 tcatccataa tgcatggtga ttatcttcat cttcaagatc atccataata tctgatgaaa 2907841 gaataagaat ttctattccc gcgccaagcc ttgttgcaac atctaaattc tcccctccaa 2907901 aaacaacata atgtaagatt gtggattcag caaaggagaa tgtttcttta gaatcaataa 2907961 atgagtaaag aagttgtgac aaatcctcgt taaatatgtt ttgctccaca atctccttca 2908021 ttttctcctt gatccggaca gaatctaaac atatctgctc aataacgact tcccccctcc 2908081 cattccattt tactaaatgg gacatttaaa ggacagcagg tttttcgttt tttaacaatc 2908141 atataatact ttatccattt attgtatcgg tagaacgaaa aaaaagactt gtttccaagt 2908201 ctttttcacg aaattttcat tgcataattg tatttatcga gttgatcaat gcttttgtta 2908261 atgtttcgta atgaatctgt cgtttcttta atatcaagtt cgagtcggaa taacaattgt 2908321 tttacttctt caagtttctt ttccatcgtt tccacactcc tttttttgaa agatcaatga 2908381 attgtgtatg gtgaacgagt cctaggtatt tgatctgtta ctaatagtgt gtctgctttc 2908441 ggctcatttt tcaccgaaaa gtatgcaaaa aagtcctgcg tgacaccgca aatctcaata 2908501 ggtccttata ctcaaaggaa tcacaacaag aacgggacta tctttctatg cgaaagagcg 2908561 tttatatgtg ctgaaattga gaaagattct taatctcctt gattttaacg ggtttcgcat 2908621 tttcactaag caagactata gtccttcata ccgtattttc aaaattgaat atgcgattct 2908681 tggcgtttcc tgaccgacaa acaccgaaaa agaccgcaac gctaaagttg tggccttttc 2908741 gctttgtcat attcggcaat tagggatcta tacatataga aacatccttt tttgcgaggt 2908801 gctcccatga gatatcgtta tccctggttt tacgtgtatc cgtatgaggt acgccgtccg 2908861 cccgctcctg ccaacaatat tgataccttt atccgttcag cgaagcaggc cgcagggata 2908921 tttgcggatg cccagctcgt tctcagccgc attgcgggct cgcgggagct ttcgcgccgc 2908981 attctgaccg cagccgaaca gtctgataaa caaactataa ggcgcctgat caaacaaatg 2909041 ggcgtccggc atgaagtgga tacggtcttt aatcccgacg gcatctatat cagccttatc 2909101 ggaacgcaaa gccgaatgat tcttgctttg cggtggtcag aggaccgcaa tcattttgcg 2909161 tccataagat tatgacacca ttccagagcc tctaaataac attcatacgc ttcttctttg 2909221 tccagttgat tgcctaattc tgagcaagtg tcccagttgt tgctttcaat taatttcaca 2909281 agctcaagca tttggtagta gtcgttttga tggcctaata atgcttgccc gacttcatct 2909341 tttaaaggca attcttgaac aatttcctct atttctctat gcaggagggt gtctatgaga 2909401 gaaaacattc cgatcagcat ataagaagca ggctgcggcc gggatgtctt tctcgccagc 2909461 agttcgcaaa gctttgctct tatcagagaa atcttaatga tttcgtgctt gctggaatgc 2909521 cctttcctgc ttaaatcctt aaaggaaaga atatatatcc accgtttgat ttcattaaat 2909581 cccagcagca taatggcctg ttgaatgctt tcaattttct ggctcaaacg gctgtgggat 2909641 gagtttaaaa attttaaaat ttgataggac agtgataaat cccgctctat gtactctgtc 2909701 acacgcttta tgttaggctg ctctttactc agttcgttaa gcagttcata gtaagaatag 2909761 aaatgagtcg ataggtcatg cccgctgatg atgcgcggct cgctgaaaaa gtagccttgg 2909821 aataattgaa agccgtcttg gaccgcctgt ttatattctt ttcgggtctc tactttttcc 2909881 gctaaaaaaa tcaggccgcg gcagccgtag gtttgcaaaa ttgttctgcg ttccattcgt 2909941 gttgttttga gaaaatcaat tttcaatata tcaatatagc tcatgagttt ttccagtaag 2910001 tcctcatctt gcggatttat tgcataaaaa tcatcaagcg ccagcatata ccccattttt 2910061 ttcaattctt tgcatctaga aatgagggcc ggcgtgatcg gtatatcttc aaggatttca 2910121 atgacaagct gtttcggatt gaaggaggtg ggaagattcg aaaacatcag gctttccgta 2910181 aaattaacaa aacagcgttt cccttccgtc agcttctcaa ttccgatgtt taaaaagctg 2910241 ttgatcacca aatctgttgt tgcctgatcg ccgtctttag cgctatacac gttctcttcg 2910301 ctttctctat acagcagttc ataagcaaca acctgttctt ttctattaaa aataggctgt 2910361 cttgcaacaa acaccctcat tgatttatcc cccttacaat acgcgcggct ttcaccccta 2910421 agtatatcaa ataatttgac gaaaattgtc taaacatgaa aaataatata tacataaaga 2910481 aaactggccc ttcgcgaatg aaaggccagt ttttctttat tcttcctcaa gctcttcttc 2910541 aattctgctt ttcacttcgt ggatccgctg cattttattg ctccagcagt cctcgcttaa 2910601 atcaaccggg tattcctccg gcttgctgat tctcttatat tcctcccaaa gcaggctgag 2910661 gttatcctgc acatactgct gtatgtctga aatctcaggg ttttggtagc aaagaatacc 2910721 cttctcaaaa atcagttcat gaagatcctt cgcataaaaa ttcgtgacaa atttgctgat 2910781 gaatgtatga accgggtgga acattctgag ccgcttctga tcattcacct gctcatcata 2910841 aagcgcaata tagtcgcctt cagaatgatg gttggactga ttaataatgc ggtagacttt 2910901 ctttctgccc ggtgtcgtca ctttttcagg attggacgaa attttgatcg tgtcgaccat 2910961 tttcccgtct tcttcaatgg caacgagttt ataaactgcg ccgagagccg gctggtcata 2911021 ggcagtgatc agcttcgtac cgacacccca gacatcaatg cgcgctccct gagcctttaa 2911081 attcataatg gtgtgctcat ccaaatcgct tgaagcaatc accttcgcat ctgtaaatcc 2911141 tgcttcatca agcattttcc gggctttttt tgacaggtac gccaaatcgc cgctgtccag 2911201 acggatgcca atgaaattaa tgcggtcgcc gaattccttg gcaaccctaa tcgcgttcgg 2911261 catgcctgaa cgaagcgtgt catacgtgtc aactaagaag acgcaatcct tatgtgtttc 2911321 cgcgtatttt ttgaaagctg tatattcatc gcggtaagcc tgcacaagcg catgcgcatg 2911381 tgtgccggaa accgggatat taaagcgctt tccggctctt acattgcttg tcgcgctaaa 2911441 gccgccgatt aaggctgctc tcgctcccca catggccgca tccatttcgt gcgcccgtct 2911501 tgttccgaat tcaagcgcaa cttcatcacc gatgacgcct ttaatccggg cagcctttgt 2911561 tgcgattaat gtttgatagt tcacaatgtt gagcaaagct gtttcaatca gctgcgcttc 2911621 taccaggggt gcctccaccc tcataatcgg ctcattgtta aaaacgagtt ctccttcttt 2911681 catggagtaa agtgaacctg taaaagataa gccgcgcaaa tattcaataa aatcttcatg 2911741 atacccgagt tcatcctgta aataactcaa atcgctatcc gtaaacttga aattttccaa 2911801 gtattcaatg gctttttcca agcccgcaaa tacggcatag ccattttcaa acggaagcct 2911861 tctgaaaaac agctcaaaaa tcgctttctt ttcatgaatg ccgtctctcc agtacgtttc 2911921 cgccatattg atctgataaa ggtctgtatg taatgacagg ctgtcatctt taaatccgta 2911981 ctctaacact gtttttcccc ttccttactc tgccacttgc gctccgatgc tgtttgcaaa 2912041 atgggaaaga gcccatgcgt gcccctcctg attaaagctg gcaacagctt gtttatgcac 2912101 aacaatccga aaacctttgt tgtatgcgtc aacagctgta tgcaacacac aaatatctgt 2912161 gcagacaccg gcaagatgca gttcgccaat ctgccgctct ctgagtttga gctctaaatc 2912221 agttcccgca aaagcagaat atctcgtttt ttccatgtag taaacattag gttcatgttc 2912281 atgtttctga tatagaggca aaagctttcc gtacagatct tttccttccg tgccttttat 2912341 attatgcgga ggaaaaagac gggtttcagg gtgatattga tccccttcat catgagaatc 2912401 tactgctaat acgacgtaat caccgtttgt gatgaattct ttagttaaat tgacgatcgc 2912461 ctcttcaatc attctgccgg gctccccgca ggtcaatttt ccgtcactcg ccacaaaatc 2912521 attcgtataa tcaatacaaa taagtgcttt tttcatagcc ggcctccccg ccatcagtat 2912581 gagaacatta tatcttatct ccagttgtaa gtgaattgcc atgaacaaaa agacaaacgg 2912641 tccgtttgtc tcttacgatt tcagtactga ccgattataa atgtcgtcct gaatatatat 2912701 caattcacga ttcacagcga tatcagccgc aatgacgatg cctaagggcg tatgaaactg 2912761 gagatcagat acaatcttga aaggcactcc gtaccggctc gccatttgga tataagaaga 2912821 gtaagactga tactgaagct ctccattaat caaaagggtg acgttatggc tgtttttcag 2912881 ctcgtgctct gcctctttat acggtttgct tctaagcacc tgtcctttcg tcagtgccaa 2912941 aacgactctt tctcttaaag agcctaaaaa caaatggcgc tcgtcaggct ttgtctccaa 2913001 aggcccatac attccttgct gcaaatagag atccatttta tcttcactca aaagcctgtc 2913061 ctcccgtctt gtttgtcttc attatcacct gatcaggcag gagctaaact ttcaagcgcc 2913121 gtttacattt ctgttaccca atgaatgatt tttttggcca gctcaccagc aggggtttcc 2913181 tctgtatgcc ggcgcaacga cgcttccagc cgttcaggca gagttgcttt atcttcttca 2913241 taggaaatga tcgtgctcca ctccagctgc ggtaccgcta caagcgtgcg cagttctttt 2913301 ctgttttcat gcagatacac gtccgtgatc attccggttt gcgtattgat atttgctttt 2913361 ctgattttca taacatgacc tctctattca aagactaccc atattataca ataaaaaagc 2913421 aacagcctct tgtgaaaagg ctgttacccg ttaaacgaaa ctgtttcatc agtgatatcg 2913481 gcatctttga agagagtttt actcgtttgg ttgttaatct tcacaaaatc accaagctga 2913541 aatgtgcctg accccgcccc tgaatgagcg acgcttttgg gcgaaatcgc aaatacgtct 2913601 ccaaagcttg ccgcggcatt atccgtaact gacatgatat aaatcggccc cacaattgca 2913661 ggcatttccc cacctccgca ttgatttaca gcatcatatg caaggagccg ataatggtgc 2913721 ccgcctattc agctggcttt gcgttttcct cgagtcgtga ccgctggcgc agcttgatca 2913781 agcggacaat attcaggaag aacgccttca ctaccgcata aaccggcacc gctaaaatca 2913841 tgccgagaat tccgccgaag cttcccgctc cgattaatag caaaataatc gtaagcggat 2913901 gggtattcag ccgctttccg atcacaagag gagacagcag gtttccgtcc agctgctgaa 2913961 cgatgacgac cacaataatc gcaaacagcg ctttggccgg cgagtccata aaaccgacaa 2914021 tgacagccgg cgcggcaccg agaaaaggcc cgacataggg aatgatattg gtaatcgcca 2914081 tgacaatccc aagaatcagg gcatacggca gtccggcaat taaatagccg ataaaacacg 2914141 ctgttccgac aaaaagacag attaacagct gcccctggaa atatgccgca agcgtatcgg 2914201 ataaatcttt aaaaatcttt aagccttctg tccgataaga agccggtaga atttttactg 2914261 ccaaatgcgg aaagcggtgt ccgtctttca gcatgtaaaa aaggataaat ggaacagtaa 2914321 taataacaag cgtgatgttt gtcacgacac caaacaccgc agataaactg gacgtgatat 2914381 tttgcggcag gttttggaga aaacttgtca atgactgttc aatttttgat atcgatacat 2914441 aatcctggtt catcatccag gtaaaccatt gagaatggga caaatccttt gtcagcgcct 2914501 gaatctgttt tatataatca ggaaggttgt taaacagccc tgtcacctgt gcggtgatga 2914561 taggtccgac tgacgctgaa ataaaggcaa gcaaaccgat aaacagtaaa tagatcaata 2914621 gaatggataa tgtccgcgga atttttttct caagcaggcg gacgaccgga ttaaatatga 2914681 aatacaaaat tcccgcaatt agcatcggga aaaacaatgt cgagataaaa acaataaacg 2914741 gctgaaatac aaatgaaact tttgttgcta caaaaataat cagcaaaaca aataaaatct 2914801 gcaatgtcca aaaatggact tttgatttca acaagctttg ttcctcctag tttttctttg 2914861 tctgtcagat aaaagaactt ataccccatc attgtaacaa aaatgaactc atatcagaac 2914921 tcttaatata atgaaaggag tgttggtgat gaaggccgtg acatacgata cagattcaga 2914981 actggcttat atctatgttc ttcctccgaa aaagaacagg aatgtacgga ctgaggagct 2915041 cagagtcaat gattgtctcc tgctggatat cagccaagat ggcaaaatcg ccggattcga 2915101 atgttttggt gaggcagcac acctctgtgc cccatttgcc gggaaatccc ggctgtatgt 2915161 aaaagattca gacggttatc attttcgggt ctgccagcat gcttcagtcc gttcctgcta 2915221 tacggtgtac cgtgtcactt tctgtttttc agatggtgac tatcaggaat ttgccggctt 2915281 tgaccttgat ggaacaatgt atcatagtgc gtttttacag cgcttaactg aaaaatagga 2915341 cgtcctgttg tacgcctatt tttcatgcgc aagcactgtt agacccgctc actgtaatct 2915401 ggggtgacgg aaatcatgtg ctggattctg atcaaacaaa cagaatttcg ggctccttca 2915461 attgtgatat ggtcaggttt tacatcgatc agtctgcctc tgaccgtatc tcgtactgtc 2915521 tgtataacga accttgagcc gatgagcttt ttaatggtct gatagacata aggatcgact 2915581 aaagagacca gttgcggact accttggttg accatacttt tatccccttt gtgtgtttta 2915641 tctcagctta tgccgcgctt atggataatg acacaggctt acctgataaa acaaaggggt 2915701 gcggagattt taggagaata cgtttggagg cgggtgtaaa ggaagtatcg atgaagcgga 2915761 gacagcgaag aaagctggcg ctgttccgta cttatacagg ctttatcacg gatgcctggg 2915821 cttggtcgat taattggtcc agcttttcta ttttttttcg tgcggttgaa ggatcaattt 2915881 ggcggtaatg atggtggccg cccggctctt catccagttc gtccgctttt ttgacaatct 2915941 gctgcagtgt gtttttatct aattcgcctt caggcaaata ggaatctgta tgaagcaaaa 2916001 tggctagtgc aatctctttt gctgctttcg gttcctcgcc aagccgaatc agaagtttat 2916061 gcgcccgttc cgccccttta atggcatgaa tgtcatttct tttgtatttc tcataatccc 2916121 actttccgtc tgtataccat tcataatggc caatgtcatg aagcagtgcc gcttttgctg 2916181 ctaaatcagg attaatgtca gccttcacag acagcctgta tgcatgataa gcgcaggcaa 2916241 tcgcatgtgc cacgccggaa cgctgaagat atttttgtgc aattggatgg gtgaaaacat 2916301 ccattaatgt aacctttctc atggaaaccc ctcctttaga tatttttaga atcctaacat 2916361 aatttgcaga gaaactcaat tcttatgtca catcattttg atcttcttat catcattgtt 2916421 ataccctaaa agcaacgttt cagtcagtat atgcggctgt tcaataaaat gcgctggctg 2916481 cagccttttg tataaaaaaa agagcagaaa atatctgctc tacaaaaact ctttaatatc 2916541 ataaatgcgg ccgttttccg tccctttttc tagtaaagaa agcagcgtgc cggcaataaa 2916601 gtccggactg cgaaggcttc ctgtttcatt taatttccgg aatcgttcaa tgtggtggaa 2916661 atcctttttc gatgaagaac ggatgacggc ctgcatctca gtgtccatca ctccaggtga 2916721 gaacgaaatc atgttcaccg gcagctcttc atcctcctgt tcaaatccga atgtcctcgt 2916781 aaacatgtcg agcccggctt ttgaactgca atacgcgctc catcccttat atggattttt 2916841 ggcggctcct gaagtaatgt tgacaaccgt ctttttgccg ctgtatgaag caaaccgttt 2916901 tgtaaacagc tgactcaaaa gcacgggcgc agtcaggttc agctgataat ggcgctgaag 2916961 ctcgtcaaga gacgcttcgc cggcacgttt gatcggcgtt accattccgg cgttattaat 2917021 aagggtaata ccagaataac gatctgaatc gatggatgag agcaatgttt caaattgctg 2917081 ttcagcttct tcgagattga tgaggtctat ttgatgctgc gttagttttt tgtgagagac 2917141 atctgttttc gttctggata aggcatggac ttcatgcccc ttttctaaag cctgtaatgc 2917201 aatggcttga cccagccctt ttgacgctcc ggtgatgata taaagttcca ttggaaacct 2917261 ccttttccgt tattattgta cggcacctct tttacacaac acaagcacgc ggcctacgcc 2917321 ttcttgtttt cctgcgctgt gacttttggg atgaggaaca cgatgcctgc aattccgagc 2917381 aggatcagta cgacatagat catcggcagc agcaatgatg atgtttcttg ttcatcttct 2917441 gtttccgttg atgatgtctt tgtcattggt ttttcagcaa aagtaattcc aagctgtttc 2917501 gactgggccg caatcgtgtt ggaatcctcg gcatttgttg atgtaaacaa atcttttatc 2917561 agctcggcgt ccttgtcctt cggtttatca aaagtgatat ccttttgttc ctcaggcagt 2917621 tctgtttttt cttcatagta ggtatcttca tgcaaataat tcgtatcgat ttcgatgtct 2917681 tttttctcat actggtttgg cgcgacatct gtattttctt cagtttgggc agccgctgca 2917741 gagggtatga aaagggaaaa ggagagcata caaatcatga tccccttttc catgctgcga 2917801 tcacgcttca tacgtttcat cgctttctgc tgtgtgttca gccatcaacc ggataatcag 2917861 cggcagagcc acggcaatca ccgtaatgat cagcagaact gttattccca ttgtaaacaa 2917921 gtgcccagta ccgtactgga tgtcgatata tactttcgaa accggatctt caaatgtaaa 2917981 gttcggcatg atcaaatcaa taagcggtgc gacatagaat aggatcattg ctgctgaagc 2918041 aacccagcca gggattgatc cgaatctgaa tgccgtccgg atgaaggcag agcttgcgac 2918101 cagcaataga atcgtaaaca ccgaccactt aatcgtctga tcgtccggca gtgaataaat 2918161 attcaagccg aacaagctga tcataagtcc gacaaggata ttcagaattc cgaataacgc 2918221 tcctttgacg agaagcggtg cgttttggta atacgagctg aaatagccga ttaacagact 2918281 gctgatcaac acaatgacaa ggatgacaac cggaggtacc gtctgaattt tttcttccgg 2918341 aacctctccg ctgattttaa gcggattcgc taagtaatca tatacatagc cattgttttg 2918401 cccgtctact aatgtatttc cgagtatgcc gtatacgtca tttcgcacga gtttcgtgga 2918461 ggcgacattt ttcccccagt tgttgtttaa ggtgtcggct ttcgcttgaa catcattaac 2918521 gctttgctgc atgttggttg tgtaatcaat gatgccggac tggcgatcag acaatgaacc 2918581 catcatgtct gacatttgca gcacttcctg gccgaccgta tcttggacac tcagtgccat 2918641 ggtaccagac agcccatcgt tgctgaacgt cgcagattcc tgtgttgcgc ccgttacaag 2918701 ctgttctgac gcttttgcgg cactttcaga gattttcgtc agttcgtcga gaacacctgc 2918761 ttgagagtca cggatatagc cgctgtagtc gtccgcaaat ttggtcatgc cgtcgatgaa 2918821 gctgttaata tcctcatctg tttgcatcgt gttgtttttg agagcttccc agctggctga 2918881 ttcttcaggt gtgagagcca ggactgattg gacgttgcca tcttgctctt ggatgacttc 2918941 acctttaata atagtcaaag agcctagatc cagattatca tttagcgtag acttatataa 2919001 atttaaagag ttgtaatact tcatcaagtt agaaatatta tcagtttcaa ttctacttga 2919061 aaaaattgaa cttagttttt ctttctgatc tatatagcct ctactctgca aagtttgtat 2919121 tatttcgtct tccaaattgt atattaacct ataagcatca ttgacattat tatcaaaatc 2919181 aaccaacttt tttgttaagt caccaatttg atcatttaat tttgaaactg ttttatttaa 2919241 ctctttaatt tcttgattta actcatcaat atgtttctct agtttgttgt tatgttcctc 2919301 ttgtttttct tgaagtgcat tttctatttc ctctaatttt atcgctgctt cgttcagacg 2919361 tttttttgca cctgaaatat cagtttcacc gtcagctccg tcaccctgta gcccatcact 2919421 ttgatttgag ccatcgtttt catctgcgag ttcaatcaaa gagaaatctg ttttagaggt 2919481 tcctgtattc tccgtgtttg tatcttgttc aggaacgttt tttgaagatt cttgatgttt 2919541 ttgtcccgtt tcaatgttag tttgaacatc attttgtgat ccattatctt gagtaccctc 2919601 ttctgatgag ccagtatctt catttgttgg ctgatcatcg gatgttggaa tatcattcga 2919661 cggttcttca gtattaggag aatcatcggt tgatggttct tcagcatcgg gtgttgttgg 2919721 tttttcttgt tcaggttctt ttaacccttc agagatatct ttaatttcag ttgcaacatt 2919781 tttgagctca tcccgctgct tctctaaatc caattttata tcttcaatat cttccttatc 2919841 tgtgtcatct ttattatcag atgtgtcttc tccatcttcc ttttcgtcgc tttccttagg 2919901 tttaagtaaa ctaaggcggt tcttcccgat attctcttgc aattgattta aattttgata 2919961 tttaatagct tcatattgac ttttatatcg agatagaaat gcattaaaca tgtcattctc 2920021 aatttttttc atacccattt cttgcaatgg cacttgattt tgccttaact tttcagcatt 2920081 gttcaacgca aggtttgtca gtcctatttg tgtcttcgct tggccgatcc cggttgccaa 2920141 tccgctcatg cgttcgctga actgattcgc cttttgctgt gcctggatgg catccagacc 2920201 tgtccggatt tgctgctgtg ttgaatcctg ggctgccaaa agcagctttt tctgattctc 2920261 ttgatattct ttgtaccttt caactgtatc aatgaattct ttcagcgtgt ttttggcttc 2920321 ctccgccgta gaagcttttt cttttgtcgt gccttgcgct tcattcattg atttcttcag 2920381 ctcatcgatt aagtcttttt gctgtttgat ttcacctgct aaatcattag agcttggttt 2920441 gtaaaagttg tacatgacat tctggaattc agattcttta ttgacgatct tgtcaaattc 2920501 tcctctgatg ttgtccactt tttgcgaaac aaaattccag tataaggccg acattttttt 2920561 gttcattgtc ttttgggcat cctcaagctc acgctgaact ttttctttgt taaccgcatt 2920621 caggttatct tgaatgctga attcgagcgt tgccttttga ggatggtctt tgtcatagct 2920681 caaaatgttt tttgagaagt ctgagggaat gtagacaatc gcatcgtatt tctttgaagc 2920741 gagaccggtc tcggccgcgc ttcggtttac gaccgtccac gaataatcag gacgttcacc 2920801 cagaacggcc gctacttcct tgccgaactg ggcggatttg tcctcttcat cagactttac 2920861 ctcatcactc aatacgcctg tgtcttcatt caccaccgcg atttgccggg tagaattgac 2920921 tgcttttttc gttgggtcgt ctccgataaa tcggaaaaac aacaccggca gcagcaaaat 2920981 gatgatgacg gcggatatta acttgatcaa gctttttcgt tgttctgtca tctagcactc 2921041 tccctttcag cagaacataa aggaatttga actttttgct ccttcccgtt ttccacaaca 2921101 tatccgaagc ccggctgaat ctcaggctcc tgtctttggt acgggagagg aatgacattt 2921161 tgctcagact ttttcatcag cagaatcgcg tggcggattt gcttcatctc agtcgtcaag 2921221 gagtcatagc cttttgagaa ttcgctgtgg tttccgcccg ggataaagct gaacccaaga 2921281 tgagcgtatg atttcatgaa gttagcgaga cgatcttgta ttctcgtatc aatcgtctgc 2921341 tggaatctcg ttatcccgtc aatcatcagc acgacttgtg agaatcgcag attttgtgcg 2921401 tctccttggc ggacggcttc tacatacatg gcttctcttg ttttgaaaat gtcttctgct 2921461 gtttcaatcc actgctcaat atcttctttc gtttccaaat atgaaacatc tgattccttc 2921521 gcataatgag ataagccgcg gtcaatcgag tcaaacaggc cgatcatttc ggtttcatca 2921581 tcaatcagat gttcaagcat gacttttagg acgtttgttt tcccgcgctg agtttggcct 2921641 aaaatcaggc agtgcttatg cttgcccaaa tcaaaataga ctgggctgac tgtttcttca 2921701 tgaagcccga tcggtacaga taaaggcttg cgttccagct tgaagcggat agacaattct 2921761 ctcgtcgaca agctctcagg cagcatcgga atcggtgccg gctgctccat tgaagcaaat 2921821 cgcccttgaa gtttctgtac gtctgatttc agctcgttga acatgccgat atcatcatcg 2921881 gcgtcaacag gcaggaacat ttgcgcgaaa taaagctctt ccttttgaat gatgacgcgt 2921941 cccggaatcg gctcaagatt gaatttcgga cggccgtaaa tggaatatcc ttctgattga 2922001 tccatgagat aatggacaat ctttgttttc aagttattta acaatgactg gcggacagca 2922061 ttcacccgcg ttgctgtcag cataaagtag atacccaagc tttgtccgtc tctggaaagc 2922121 tggacaaatt ccgattcaag ctcatgcatc tcatccttga caatgtcaaa gttgtcaatg 2922181 gtgataaaaa tgaatggaag ctcttcttcg ctcagcgcat tgtacatttt gatgtggctg 2922241 atttcttttt cccggaacaa acgtttacgg cggtcaattt cttctttgat gcgaatcatg 2922301 aacttttcaa ttttccttga ctggtccatc aggaagtaat ccgcggtatg cgggagcttc 2922361 gctaatggca gcagcgttcc gtttccgaaa tcaaagatat agacatgaag ctcttcaggt 2922421 gtgtatacgt ccgcaaaact catcaggaac gttgcggctg caatcgattt tccgtagccc 2922481 gaagagccga agatgccgat atttccatct tccatcatct tataagcaat tggcgcctgt 2922541 ctttgcagat caggttcatc gacatacgca aagtggaaat ggtctttttc gtttgaaggg 2922601 aaaagagtgc gcggaatacg ttccgcaagc ggcggcagcc aagggcttgg cagcttctcg 2922661 attcccattt catcttggat gcgttcaatt tcgtcaacta cagcttcgat ttcggtttga 2922721 acgtcttttt tcgcgttatc ttcggtatca acctcagaaa gcgggatcag acccgtatct 2922781 gtgacgatcg cgatttcatc ctcggtaccg tagacttcct ctaagtaagg cgccccgctc 2922841 catgcagatt ggaacagctc atacacttca ttgtttccga cctgcaaata gccgcggcct 2922901 gttacggtaa tgtttgcggc atcgctgttt ttcaaaattt ctttactgtc ggtggcatcc 2922961 tggaccttga gcgctacttt aaagcgcgag ttactccaga tctggtcgtc gatgatgccg 2923021 cctggcttct gtgtcgccaa aatcaaatga acgccgaggc ttcgtccgat acgcgcggca 2923081 ctgacaagct ccctgataaa atcaggctcc tcgcttttca gctcggcaaa ctcatcagaa 2923141 attaagaaca agtgaggcat cgccacttct gctttccctt gcttgtatag ctttgtatag 2923201 tcattgatgt gattgacttg atactggtca aacaggcgct gccttttttt tagctcgctt 2923261 ttaatggaag caagcgcacg catactgaag tttttgcttc cttcaatatt tgtgatcgtg 2923321 ccgaggaggt ggggaatgtt acggaacggc tgcgccattc ctccgccttt atagtcaatt 2923381 agtaagaaag ccgcttcatg cggatgaaaa tgcactgcaa gtgacaagat gtaggtctgg 2923441 agaaattcac ttttccctga tcccgttgtc cccgcaagca agccgtgcgg accgtgtgct 2923501 ttttcgtgaa ggttcagata cacaatgtca tctttccctt tatagccgat cggcactgac 2923561 agcgacttcg acgattcact tgtcagccat ctttgctgaa tgccgatttc ttttacttcc 2923621 ttcgcatgaa aaagctccag gaacgatacc gtttccggaa tggaattcgt aatgccgacc 2923681 tggtggttca gcgtccgcag tgtgcgtgaa aaccgttcgt tatcctcacg ctgatgatga 2923741 tcgagacgga acggaattct taccgctttt ttcttttgta ttaaaatgtc gccttcatgc 2923801 tcattaatgt agcggacaag agttgtaatg ttttccgaca agctttcctt tgtttctgca 2923861 gcgacaattg tcgagatgcc cagatgctca tgctgccctt ctaaatattc gagaatgaca 2923921 tgctcagaga tcagctgctg attcgtgatg acaaatacaa aatgcggttt gaactgcagt 2923981 ttttctttgt catcttcgag atcacgctct ctgatcaatt cgtaaagtga agacaggagc 2924041 tgatctcggg tttgctcatt ataaataaat ccttttgcat aaatatgggg catttgaaat 2924101 tgcggaagcc acttcatcca ctcccagtct ttatactctt cttcatgaaa aataaatacg 2924161 aaacgcaaat cgtgatagct gttaaagaac gacagctgtc cgattagctg gtgaatctca 2924221 tttttcacaa tttgtgattt accgacaagc cccatcggac cttctgccaa atcgaccgtc 2924281 accggcgcat tacggatatc tttatagacg cgttgcatgt gctgcgattt ctccatgagg 2924341 tcatcgatat cacgattcgc caagtctccg ccactcatat tgatttcata gcttgacgga 2924401 actgttcccg tcccaagccg cagctggaga taatccttgc tttcaagtga tttttcccag 2924461 atccggtcac tgatttcact tgttaagtat ttcatttgtt caaatgaagg aaagtgaaat 2924521 tcaagaacct gcttttgctt ttcagcaagt gcctgaagct ctttccgctt attgtctaag 2924581 taaagcttat atacacgctc ccgtttttcc tcgcgttttt tccgctggtt tttatcacgg 2924641 aaatattgca ctgtcgaggt aatgagagtc atcataaaca tcgccaaaga aacgagtata 2924701 aatatgccgc gcggctggat gatggcaact acgcccatca cgatcagcat cacaagcgga 2924761 ggcaggatga cgagccacag ccctctgttg gtttgatcgc tctcctgaga gggaaaactg 2924821 aaagaaacgc ggtcatccgg cagatcgtat accatccgcg gcgttcttct gtactgcgga 2924881 tattttttct gcatctctgt actcggtttg accgtttctg ttaacgctgt ttcaaactgg 2924941 gcataatgaa caatttctaa aaggtcttgt tccgtcaccc tcatttgcgt gaagttccag 2925001 aatatttcat cccccggctt gagcggcgta ttggcgttga ttttctctcc gttcaagaag 2925061 atcgttccgc tttcagggcg gaccgaccag ctgccgcctg cacggagcaa agaaaacgtg 2925121 ctttgttctg caaatgcaaa atcttgcgga ttcagataaa tatctgcatt cgttttttct 2925181 gaggaacata caatttcatc ccgatttccc gtaaaataaa cggatttctc aggttcactg 2925241 cccgtcaata tcaagcgtat atcctgctga tccgtttgga gagtaaatga tatatccgtc 2925301 tcaatcgtgc cgagacaatc atttcccagg aaaacttcgt attggccgcc ggattccttt 2925361 cttttaagag aaatcactcc gctattaaat ggaatggtgc tgatcgtaac agaatccttc 2925421 acatcaggcc ctatggtcac cggatgagac gacgggaggt tagacagatt taatttttga 2925481 acgttatttt ggtaaaaaac ccataataga ctcaaatggc gaaccccctt acggccgaat 2925541 ggcagcatgc gatgacctgc gcttcatgtc tcacgttatt tgtcatcttt tttctcatct 2925601 ttcttttctg tttctttttt ctcgtcttct ttttccttct gttcttcttt tttcgctttt 2925661 tcctcggctg cggctttttc ttctgccgct ttctcttctg cttgtttttc ttcgtctgtt 2925721 tgtgtctgtt cttcgcttgt atcgactaac gatgtttcag aattagactg tttattttct 2925781 tgacgttctt tttgggcttt ttcaagctca ctatttactg aatcaagttc tttttgtatg 2925841 tcttcatcat ttgtatcctc agataaaagc tgctgtttat atttagctag ggcaaagtaa 2925901 atataatcat tgtattccag cttacggccg atactgatcg cttctttgta ttctcctcga 2925961 ccataatcaa tccaatataa gaaatgctga gggtctgatt gaagggtgac taaattattt 2926021 tctatatttt tggtttttgc actccccagg ttttcgacct caacatagga cgtcgccagc 2926081 tgatactgca ccgattcagg caggctttcc gcatcgtact tggacagtgt gctgatgact 2926141 tcactgtact gcttgtttaa gaacgcacgg ttgctgtcca ctatcgcctg gtgctttggc 2926201 tgcgcgaaaa ataaggcgta catcgaataa ataagtgccg gtacaagcaa aacaatgagc 2926261 cccaggccga tatatcgctg gatgttccac ttctttctcg ggatatgtat gtatgttttt 2926321 gctttggctt cgagctcatc aatatgggtt tgaatcagct cgagcaaatc atcataggat 2926381 tcagcatcta atatcgcctt tgcctctgcg gagaacgtca gcgtttcatt gaatttcagg 2926441 tagtcttcaa acgcaaaagc gccgtcaact gccaaagccg ctgccgcttt cagctcctgc 2926501 catactcttt cctcatcacg ctcgtaagga ggaatgcttt cttttactcc ataatggaga 2926561 aaataaggcg taagcccttt atcgaataca atgttttcag gagcgacaat caaattcagc 2926621 ctcgacagat tgtgctgctg tacggcttga acaagctgat aggcaaactg ccatttactt 2926681 tttttatcct tagctttcat gaagcggaat gctttatagg aggagggagg ttggattgtg 2926741 atgattactt catcatccgt cacatcgatt tctttatgaa aaaatggatt tatatctttg 2926801 atcacgttag cttcaagacc gtcgagaagc tttatttttt cccgttgaaa ggtaaatgta 2926861 tagccggcat ctgttttctc ggcaacagct tctaattggt tttctaaata tgatttttgt 2926921 tcacctgaca ttcaaccaga tcctttcata atatttcaag ccggtctccg tttgtaatgc 2926981 cgcaatcaga cagcttgcat tctccggaaa acaccttatc cttgttcacc actctgatcc 2927041 agtgcccttc gcgcggaggc atagatacgc tttgggcctg ccaagcaata tcaattactt 2927101 ttttcaccgg gtggtaatct gacaatctga gatcaaagac actgccgtta taatgtttca 2927161 aatctattgt aatatcaata tacatttagg atcaccctta catagaaaga gcgccgtctt 2927221 cttttgaatc aggcgctcct tccctttcat actgttatcc gcggatttga tttgcgatgt 2927281 cttggtcagt agactcaagt gtatttgctg tttgatcaag ctgctgattc acatcttgaa 2927341 gcaaatctga cattttgata aatgaaggtt tgagctgctc gtattgatct gcgaacgctt 2927401 cgcttgaagc accttcccac atgcttttca aatcagagat cattcggttt aaacgatcaa 2927461 cctgatttaa tacttcttgg ctttcaacgc cgtattgctt cgccatcgct cttagctctt 2927521 cgggtgtgac acgaattaat cctgccatat tcctcattac ctcctgtgcc atcagcctaa 2927581 atatgggcta attcacttat ttttagaacg tcattattat aaaaacagtt tttcggcata 2927641 gtcaaacaaa tatgttttaa ttttacaaaa tgagtccaat ggtttacccc gaatcactca 2927701 aaaatgacat atactgtaaa gtaaataggt ttattttctt aatcttctct tcattctccg 2927761 aataatccaa aagacccaaa taactctcca actcccaaaa aaaacctttc agaaaatttg 2927821 atgctacagc accatttctg aaaggttcag ttttttcttt ccttaattag tcttgcctcc 2927881 gatgactttc ttagaagatt aataggataa gctgtcgtat tatatgagac atacactgtc 2927941 ctgcaaaaag gcgattacac cgccaaatgt atatagaacg tttctctcat gaaattgttt 2928001 ttttgcttct gttctttgtt gttgattttc acaaacaaca acaatcataa taaaaggaag 2928061 gggatgagat gtcaaagaga aatcaagcac gaaaagtagg gagatttatg accatgccga 2928121 atgatccgtt taaatatagt tttgacagac ttgaagatgt ggctgatcat atcagcgacg 2928181 ttctgcggtg cccgatcacc atagaggatg ttaaccacaa gctgcttgcc tacagtacac 2928241 acagcgactg cacagaccct gcccggacgt ctaccattat tggcagaagg gtaccggaga 2928301 aggtgattaa caagctgtgg aaagacggga caattcctgc tctcttaaaa acggaccagc 2928361 cgatcagagt caagcaaatc gatgaagtcg ggctgagcaa tcgcgtcgct atttcgattt 2928421 ggaaaaacaa gcaagtactt ggcttcatat gggcgcttga gatccaaaaa acattgtccg 2928481 atgaagatct gctgacattg caaatggcag caaaagcagt gaaaaacaag cttctcaaac 2928541 ttcaaatcag aaaaacgaaa aatgaagaac gcagccaaga atttttctgg aaaatgctga 2928601 ccggacacat ccatcaggag gatgatatgg cggatgggtt ccataagctt ggaatggccg 2928661 ctccttcaga gttttccgtt atgatcatcc gcataaatgg cgagctgact gaaaaaatcg 2928721 aacagcagct gcaatattta caggaaacga cccagcaggt ttacgtgctg ctggcgaccg 2928781 tagattccaa tgaacttatt atattaacct cacccaaaac agatcatcct tttcaagatt 2928841 taaaacagtt tgctttaagt acgcaaaaac agctgaagga gcggtataaa atagaagacg 2928901 tttctatcgc ttttggcgga atatacaact ctatttcttt tgtctcccgc tcctatcagg 2928961 aagcattgtc cgtcttaaaa acgaaggaac ggttcgctga agagaccaaa catcttttca 2929021 gcttttctga gttaggcatt tatcaatact tagatgtctt aaatgaaaaa cggaaacagg 2929081 cgggccatta taattactcg ctttccaaac tggaacaata tgaccgggat caccagtcaa 2929141 atatggtaga gacgctagag cgctttattg aagcggacag caacgtgaat accgcttcca 2929201 agctgttaaa tatacacgtt aatacgttga attaccgact caagcggatc agccagatcg 2929261 ctgaaattga tttgaaaaat gtgaatcaaa aattcaccat ctatttagat atcaaacttc 2929321 ggcacatgga tttgtgaaat ttcacaaatc catgtttttt tattttctta atcaaacaaa 2929381 gaattttcca aaatatcaag ctacactaaa aatatcacat atacaggagg agacagatat 2929441 gatcataggg gttcctaaag agataaaaaa caatgaaaac cgtgtcgcat taacacccgg 2929501 gggcgtttct cagctcattt caaacggcca ccgggtgctg gttgaaacag gcgcgggcct 2929561 tggaagcgga tttgaaaatg aagcctatga gtcagcagga gcggaaatca ttgctgatcc 2929621 gaagcaggtc tgggacgccg aaatggtcat gaaagtaaaa gaaccgctgc cggaagaata 2929681 tgtttatttt cgcaaaggac ttgtgctgtt tacgtacctt catttagcag ctgagcctga 2929741 gcttgcacag gccttgaagg ataaaggagt aactgccatc gcatatgaaa cggtcagtga 2929801 aggccggaca ttgcctcttc tgacgccaat gtcagaggtt gcgggcagaa tggcagcgca 2929861 aatcggcgct caattcttag aaaagcctaa aggcggaaaa ggcattctgc ttgccggggt 2929921 gcctggcgtt tcccgcggaa aagtaacaat tatcggagga ggcgttgtcg ggacaaacgc 2929981 ggcgaaaatg gctgtcggcc tcggtgcaga tgtgacgatc attgacttaa acgcagaccg 2930041 cttgcgccag cttgatgaca tcttcggcca tcagattaaa acgttaattt ctaatccggt 2930101 caatattgct gatgctgtgg cggaagcgga tctcctcatt tgcgcggtat taattccggg 2930161 tgctaaagct ccgactcttg tcactgagga aatggtaaaa caaatgaaac ccggttcagt 2930221 tattgttgat gtagcgatcg accaaggcgg catcgtcgaa actgtcgacc atatcacaac 2930281 acatgatcag ccaacatatg aaaaacacgg ggttgtgcat tatgctgtag cgaacatgcc 2930341 aggcgcagtc cctcgtacat caacaatcgc cctgactaac gttactgttc catacgcgct 2930401 gcaaatcgcg aacaaagggg cagtaaaagc gctcgcagac aatacggcac tgagagcggg 2930461 tttaaacacc gcaaacggac acgtgaccta tgaagctgta gcaagagatc taggctatga 2930521 gtatgttcct gccgagaaag ctttacagga tgaatcatct gtggcgggtg cttaattcac 2930581 aataagcttg cagaaagatt tctgcaggct tttttatttt ttaaaaggaa aaaagagacc 2930641 atttcacgaa ttatgactat gaagttgatc ataaaggagg attcatatgg ctgttcagca 2930701 atatggcgtg ttaaaaggca tagtattaga catgaagcgg gaaacagatg atgacagtcc 2930761 tcatttccaa gtcaaaatgc tcggtgaaga gaatacgtat tacaggtgcg ccatcaatgt 2930821 gatgtccagt tctgaggaat ctgaagtatt gtatttggct gacgatcagt ttgattcggg 2930881 ctcaattacc atccttccga acatgccgta tggatataca aggatcaatg aagcaaaccg 2930941 tgaagtggca ctggattatg tgcggggcaa tttgtttgac ccgcgggaaa tgaagccttt 2931001 gcctcatgaa atcacgggac ctgataatga tttaaatgat tttattgaaa cctatatgaa 2931061 gaaagcacaa gatgagaaaa cgccggttta tatattcggt tcaaaattcg gccctgaaca 2931121 ggctgcagat aaaatattcg gctttacccc gactaacgga atgcacaata tccatatgaa 2931181 tcaagggaat gcaatggata cccgctggaa aaaagacaac ggctcttggc atgacggggg 2931241 tattctgatt cagtttgcag atcagtgggc cgctgtgttt ttagcgtttt tatcccaatc 2931301 ttggtgtacc gatgaaaacg gaaaccctgt cagagattgt gatcataccc aaacgtctgc 2931361 gtaagataga aaaagagact gcggcaagca gtctcttttt gataagatta cacattttca 2931421 acagtcttta ggctgtttgg cctcatatcg ctccaatgcg attggatata gtccaaacaa 2931481 gcttcacgcc ctttttgctc atgaacgact gtccagccgc tcggcacatc tataaaaccc 2931541 ggccataggg aatattggcc ttcttcattg accagcacca aatatgtgcc atccgcattt 2931601 tcaaaaggat ttgccattct atttctcctc ccttatttat tcaactcttc caatttgaca 2931661 gcgagaacct tgccgatttg agccagaggt tcaggctgac ataaatcttt atgacggcag 2931721 tcgatgtcga tttgttcaat ctgtccgtta atataaggct tccacgagtc aggttcaatc 2931781 gggtcaaacc attcaggaat gattgttgat ctgaaaaaca aaacatttcc gcggaaggtt 2931841 ttcggcttat aggaacctaa aatgccgaca gaatttacat acgtattctt caaatttaaa 2931901 atgaccgttt catccaggct cgcaagcgca ctgccgtcac ggcgaagaat ctcaatcgcc 2931961 gcttcaaaat ctagcggttt ttcccctaag ctgtctggat catacccgcc taacgccaga 2932021 agggcaataa gcgcttcctc atcatccggt gcctctttta taggaaggaa gtggttcgga 2932081 taggcgtcca gcatcaccaa cagggatact tcttctcctt gattttgcag ctgggtagcc 2932141 atcgcttgaa cgacattccc gcccagggac cagcccagca gatggtacgg gccttttggc 2932201 tggaccgttc ggatttgttt aatgtaatcg gcagccatgt catcaagtgt tttcggaagc 2932261 tcctcgcgct gcccgattcc ccgtgcctgc aagccgtaga tcggataatc tgttcctata 2932321 ttggtcatca aaccggcata acaccagctg agcccccctg ccggatgaac acagaataaa 2932381 ggaggcttgt ctccgcttgt tcggagcggc agcagaacgt caagagcgct ttggcttgat 2932441 cccatttcaa gtctttcagc gagcccggct acagtaggtg cttcgaacaa gttgccgatg 2932501 ctgagttcaa cgccgagcgc ttcacgaatg cggctcatga gctgtacagc aagcaaggaa 2932561 tgtccgccta aatcaaagaa acggtcatca atgccgacac gcggcaagtg aagcacctcc 2932621 ataaagaggt cacagagaat ttcttcctgc ggcgttctcg gtcctcgtcc tgtcactgcc 2932681 gctgcgaaat ccggagcggg cagcgcttta cgatcaagct ttccattcgg tgtcagcggc 2932741 aattctttca tcgtcacaaa ggcagcaggc accatgtaat ccggcagtct ctcagcagca 2932801 tatctgcgca gttccgccgt atcaaatgtt tcttccgaag ggatgacata agctgctaac 2932861 cgtttatctc ccggctgatc ctcacgaacg atcactgccg catcttcaag ctgcggatgc 2932921 tgaacaagcg cggcttcaat ttctcccaat tcaatccgga atccccgaat tttcacttga 2932981 tggtctgcac ggccgacata gtcgagagaa ccgtcagcgc ggaggcgggc cacatcccca 2933041 gtgcggtaca tccgggtgcc tggaggaccg aacggatcag ctatgaagcg ttcagatgtt 2933101 aaaccaggcc ggcctagata acctcgtgct aaccccgctc ctgatacata cagctctccg 2933161 gcaacacccg gcgggaccgg ctgcaggcgt tcatccagca cgtatacacc aagatcggga 2933221 atgccgcagc cgatcaagct gtttgcccgt aaagctgcca tgcttcggtc taattcgata 2933281 tagctcacat gcaccgtcgt ttctgtaata ccatacatat tgataagctg cggtctattt 2933341 tcagggtggc ggttgtacca atcctctaaa cggctgagtt caagcgcttc tccgccaaaa 2933401 atgacatagc gcagactgag tgcctgtccg agatccggct gttcccgttc cgcctgcata 2933461 aactgataga aagcagacgg tgtctggttc agaacagtca ccccctcttt gacaagcagg 2933521 cgcagaaacg cttctggcga tctgctgacg tggtgaggca cgattacaag acgtccgcca 2933581 tgcagcagag gaccccagat ctcccacacc gaaaaatcaa acgcatagga atggaacatg 2933641 gtccagatat cacctgagct gaaacggaac cagtgctcgg tcgctgcaaa taaacgtgtt 2933701 acattttggt gaggaatcat cacacctttt ggaacacctg ttgagccgga tgtataaatg 2933761 acatatgccg tattcaaagg ggaaagcggc tgagtcctat ccttattttt tggattacct 2933821 gcagggtacg tgtttagttt ctctgccagc tcgggatcat ccagcacgat tttcggcacg 2933881 ttttcaactg gcggaatgtg atttgcagct ttagtgttcg tcatgataaa cgcaggctgt 2933941 gcatctttta gcataaaagc aattcgatca gccggataat ccggatcaag agggagataa 2934001 gctgccccgg cctttagcac cgccaatagg ccgacagcca tttccaacga tcggggcagt 2934061 gccaatgcca caaattgctc cggcccgaca ccttcactaa tcatcattcg ggcaagccgg 2934121 tttgctcttt cattcagctc tgcatagctc agttcctgat tttcatatac aacggcaatg 2934181 gcatcaggac gtaaagcagc ctgcttctca aattgctctg gcaaacatgc gtgcggaatc 2934241 ttttcagata cactttgcca atcagtcacc atgctgctgt gttcctctgg cgcaagaata 2934301 tccagatttc cgatttgctc gtcaggatca gactcggcag cctccaacag gcgcatcaat 2934361 cggtcagcaa gagcctgagc agtttcccgt ttgaaaagat cagtgctgta ttcaagcagt 2934421 ccttccattc cgtttggtgt cccgtcagca aggcgatctt cactaatttc cagcgtcaaa 2934481 tcaaacttgg cagaaccgac actgttgatt cgcaggctgc tctccatatc aggaagatgc 2934541 agttcagcgt ccggtgtgtt ttggaacgca agcatgattt ggaataaagg atgcgtcgca 2934601 cgcgaacgag ccggattgag cacctctaca agtctctcaa acggcagatc ctgattgtca 2934661 taggcggcca gattcacttc ccgtactctg tctagaagct cacgaaagct tgggtcaccg 2934721 gacgtatcag ttctgagcac caatgtatta atgaacagcc ctacaagatc gcccagcgca 2934781 tcatcattcc gtcccgcgat cggactgccg atcggaatgt cggtgcccgc cccgagcctt 2934841 gtcaataaag cggcgagacc ggattgaagc accataaaca ggctcaccct atttgcgcga 2934901 gccagctcct gcaatcgctt gtgaaactcg ggctcaatac gaaaatgaat cgtatctcca 2934961 tcatgactcg gctcagccgg acgtgaataa tcggttggca gttcaagctg atcaggcagg 2935021 tttttcaagg tttctttcca gaaagcaagc tgtccggcaa tcaagctatt tggatcatcc 2935081 tcgtttccaa gcagttcttg ctgccaaagc gcatagtctg catactgcac agcaagaggc 2935141 gcccattcgg gagatcgtcc gtggcagcga gccgcataag ctgtcccaag gtctctggtc 2935201 agcggtgtta aggaccagcc gtccccgaca atatgatgga cgagaagaag cagcacgtac 2935261 tcgtcaggac cgatcacaaa aagctcggca cgaaaagcag gttcagctgc aagatcaaag 2935321 ctgtagcgta cagcttcggc aagccgatca gaaagctcct tctcagcaat ttcagtaaca 2935381 tgtaactcgg gacaggctcg atcggcatct aaaatatgct gataggatgt cccctgtgat 2935441 tcagggaaga tcgtccgaag actttcatga cggcagacga ggtcataaag tgccgctttc 2935501 agcaatcctt gatccaactc acctgacaaa cggacagcaa ccggaatatt ataagtagga 2935561 ctcggtcctt ccagacaatg caggaaccat agccggcgct gggcaaatga gagcgggatc 2935621 ttttcaggcc gctcagctct ctgcaaagcg ggacatgcac tctgcgccaa atcaagatgg 2935681 gcagcgagtc cggctactgt cggttcgtca aagagcttgg cgataccaag ttcggctccc 2935741 attacctcgc gaatgcggct catcagacgg gctgcaagaa gagaatggcc cccaagctcg 2935801 aagaaactgt catcgatacc gacgcgtgcc aaaccgagaa cctctgcaaa caagtcacac 2935861 aatatctctt cctgaggagt ccgcggggcc cgatcactga cagatgtgct gaagtctggt 2935921 gccggcagtg ctttccggtc aagcttgcca ttaggtgtta acggcagctc gtccatctcc 2935981 acaaacgccg acggtaccat ataatcagga agactagccc ccatataacg acgaagctct 2936041 gcagtatcaa tagcagcatc agcgactaca taagccgcca atcgtttgtc tcccggctga 2936101 tcttcccgta cgacaaccgc ggcctgttca atgtgcgggt gattggcaag cacggcatca 2936161 atttctccaa gttcaattcg gaatccgcga attttgattt gatgatccgc ccgcccgata 2936221 taatccaaag acccatcggc gcgccagcgg gcctggtctc cggtccgata catccgagtt 2936281 cccggcggtc cgtatggatc tgcaacgaag cgctccgccg ttaaatcagg acgatggaaa 2936341 taacctctgg ccaagccggt tcctgcaata taaagctctc cgacaacgcc cggcggcacc 2936401 ggctgcaatc cattatcaag cacatacacc tgcgtgttcc aaatcggttt cccaatcgga 2936461 ggaacgccct tcagcccttc ttcaagaaaa gctgcggcag accaaatcgt tgtttcagtg 2936521 ggaccgtata agttcgtgac tgaacaatga aggtcttgaa gttcctgcaa aagaccgctc 2936581 ggcagcgcct cgcctcctac aagcactcta agcccccgaa gtttctcagg ttcactcgtt 2936641 accaaagcgt gccacagtgt cggtgtcgcc tgcataatgt taatatcgaa attttcaatc 2936701 atttgagcta atgcctgcgg ctcacggatc gtttctttct ttgcgatcac gatttgcgct 2936761 ccgctaatca gcggaagata taactccaat gctgaaatat caaaagcgac agtcgtcaca 2936821 gccaacagcc tgtcttcttc tcctagagaa aatgcctcct gcatagacag cagaaaattg 2936881 cttaagcttt tctgtgtcac aacgactccc ttcggtcttc ctgttgatcc tgaggtatag 2936941 atgatatacg caggatggtc aagcgaaacc gatacatcct gattttccgg cgaatagcgt 2937001 tttataatct cctgtgtaac agcctgatca agcacaagct caggtacagc caggtcatca 2937061 ggcagactgg ctgctatttc ctcagtcgtt atgatgcatg aaggtttcgc atcctccagc 2937121 atgtaagaaa tgcggtcggc tggaaactcc ggatcaaggg ggagatacgc cgcaccagtc 2937181 ttgagcacac caagcattga agccaccatc tcaggggaac gcggcagcgc caaagcgaca 2937241 aattgctccg gaccaatccc tttttcgatc aacagacgcg cgaggcggtt tgcctcttca 2937301 ttgagctttc gatagttgac ttgaatgtca tcacacatga gagcgatacg ttctggcgta 2937361 agaactgcct gcttttcgaa catgtcctga aggctgacca gcttctcgga ttttgccgtc 2937421 tcattccatt tagaaatgac tttttctttc tcctctggca acagaagctc catttgccca 2937481 atcagcatgt cctctccggc agaagccgtt tgcagcagct gcaaaatacg ctgctgatga 2937541 agcttaatat cagactcact gtatacctcg ggattcgcat caacatcaat tcgcagcccg 2937601 ctgccgtctg ttctgtcata tacattgatt gatagatcat caacaggacc ggctgaaaga 2937661 ttatgcgttg tgccccggac gccggcaaag tcgagaccgt aatcaaacgg cataagattg 2937721 atttgagggc caaataatct atgattttct cctatcaatt tcagatcgcg cctaagctct 2937781 tcatggcgat acttatgatg tcgccgaata ctgcggattt cccgggaaat ttgctgaatc 2937841 agttcagaaa agctcatcga agagcttacc gtcagccgga gcgggagaag gttcatcacc 2937901 atagccggta cattcagtga cgcggaccct atccgaccca tcatgggcag gccgagcaca 2937961 acatcctcag agccggtcat acggtgcaca taaacagctg acaccgcaat catgacttca 2938021 tgccagcttc ctgagaaata gcgcgccgct tcttttaacg cgtttacatc agacggaggc 2938081 agatatgccg tatgacgaag aaaactgtta gatgttcttg gcgcccgatc agccaagctc 2938141 acaacttcag gtgcatctgc aaaacggtcc agccagaatt gacgatcctt ctcatactgc 2938201 tctgatccgc gataatctgt atcctcctcc aaaatggcct ggagagaccc aaaggaacgg 2938261 cttttagctg tttgtccttt tataagggca gtatatgtac ttgccacacg ctgggctatc 2938321 agggaaaaac cgaagccgtc gatcgctata tggtgaatgc gctgatacca aaagaaacga 2938381 tcaggcccgg caataaacag agcttcattg aacaaagggg cataccctaa atcaaccggc 2938441 tttgctaaat cagctttcat ccagtttaat gctgtttttt ccggatcagg ctcagagctg 2938501 acgtcaatga cgtgcagctg tacatccgga gacgggttta tcatctgcca aggcccgtcc 2938561 atattttcac cgaagcggac atgcagcgat tccgcttcct tgatcacgtg ccgcaaagct 2938621 tcttcaaaaa gagcaatatt gactggtcca ttgatttcta tatattccgc tgtattgtag 2938681 attggattgt ccggatcaag ctgctgagca aaccatatgc cagtttgcgc cccggtcaaa 2938741 gaatattgaa gatcttttgt atcaggcatc cgtttgttta ccctcctttt ataaataatc 2938801 cgcgtttggc agcacttgct ggctgcgagt tgtgagcaat ttctgccatt cttcgatcgt 2938861 tgggcgttca gccaattcca cgaaagtcac ctctgcccct tcacggcgcc attgttccac 2938921 caatgtcatg atccttaccg aatcaagacc acgatcgagc aaatcctctt gatctgtgat 2938981 gtcttccggt gtttcttgta gaagctcagc aatttgttta cggatattct cacatgtaaa 2939041 cacgttcttt ttgccagtgt ttgctgacgt tttttgaacg tctgccggcg cattctgcag 2939101 ctgatcaaga agactgtcag tcatcacggt aaacgcacag cgtccagccg catattccag 2939161 cgccatttga tgtttttcta atgaaaaatc agcaactgca tctcccacaa aaaaggcttt 2939221 aatatcctcc ataaatgctt cacatgctgt aacaagacag ccgatatggg cgtaaattcc 2939281 tgtaatgatc agctgatcgc gtccctcttt gcgcatcatt tcaagcagat tcgttctctt 2939341 aaacgcgctg tatctccatt ttgtcagcac aagatcatca tcctctggtg ccagctcggt 2939401 tataattttc tcctcataag gaccgctgtt taatcccggg ccccaaaagt ctgtcagcag 2939461 cgcacggtca tccggatttt ggcttcccgg ctgtgcggta tagacaacag gaatcccaag 2939521 ctgaacacat tgattcttca gctttcgtat attcgctgaa agctctgtta ccggagacgc 2939581 tcccgctgtg aaagcatcaa caaaatagtt ttgcatatcg tgtattaaca agacagcccg 2939641 attcggatca ggcacccatg atactttgtt ttgcggcata tcagatgctg tcggcatttg 2939701 atacggctga atggcaggta tagccatatg aacacttcct ctcaaattgt tgttttattt 2939761 tttaaatcct gcaagaagct tctcggaaat ggcttcacgg agcgcttttt tgctgacttt 2939821 tcctactcct gtctgcggga aggattcgac aaattcaact cgatcaggga ttttatatgc 2939881 cgccagtccg cgctctctca aaaatgcttt aagctctgcg gcttttgggg cttcatcccg 2939941 gggaataatg aacacacaag atctttcgcc aagaaattga tcaggcatgg agaccattgc 2940001 cgcatcatgg acagccggat gcgccagcag atgattttct acctcttcag ccgcaacctt 2940061 ttctcctcca cggttaattt gatccttcgc ccggccttca acgacaatat agccgtctcg 2940121 tgtcagcctg acgatatcac ccgtacggta aaaaccgtcc tcagtaaatg aagcggcgtt 2940181 atgctcttct gccttatagt aacctcgaat tgtatacggc ccccgcgtca gcagatggcc 2940241 tgtttcacca ggttttacgt cgcgatcatg atcatcccaa acacgcattt catcatatgg 2940301 agacatcggt tttccttggg tgttgacaat gatctcctca ggatcatcca atctcgtata 2940361 attgacgaga ccctctgcca ttccgaacac ctgctgcagc gtgcagccga aaacagcttt 2940421 taccctgcgc gcggcttcag cactaaactt ggcaccgccg acctgcagca cttgaaggct 2940481 ggataaatca tcacggcgtg aggatgccgc atccatccat accatcgcaa gaggcggaac 2940541 aagagcggtt atcgtgacct tttcccgttc aattaaagga aatgcgtcat ctggacttgg 2940601 agaaggagat aataccactc ttcctccagc gtataatacg ccgagaacgc cgggtgagct 2940661 cagcggataa ttgtgtgcca tcggcagcgc ggccaagtac accgtgctgt ggtcgagcca 2940721 gcagacctcc acactccgct tcaggctgta tatgtagtca tcgtgggtcc tcggaatcag 2940781 tttcgatagc ccggtgctcc cgccagaaag ctggaggaac gccacatccg atgatttgac 2940841 ttcaggcagt tttacaggtt ctgcatgcaa atcctccagc ggtaaaaatt cctctgcctc 2940901 acctgcgaca atgatgtttt tcaaagtcgg cagcttgctt tgaacctgtc tggcaagcga 2940961 acggtagtca aaaccggaat aagcgtcggg aatgatatat gcagccgctt cagcaaactc 2941021 gcaaaaatat gtaatttcac tgcttcgatg agaaggcagt gcgaagactg gaagcgcccc 2941081 cagacggaaa agcgcgaaaa tgacttcaaa aaactctttg atatttggca actgcaccac 2941141 aacacgatcc atctgttgaa tgccgagctt ttgaaatccg gcagccaggc gatcagccct 2941201 tgtgtcaagc tctcgatagc tccaatgggt gtttccgcat gtaatggcaa tgcgatcacc 2941261 atatttggct gcccggtccc ttaacaaatc tccaaacgtc tcaccggccc agcagccgtt 2941321 ctttcgatag gtctcagcta actcatcagg ccaaggcgta aatcctttca gcatgttgta 2941381 tccctccagc aattcattct gttcatatgt gatccacgcc cattgcccgc agcattgtcc 2941441 gaaactttgc ggacgtctcc tgaagctcgt cctcaggctt tgaaccggcc acaacaccag 2941501 ctccagcata caggcggagt gagcgttctt ctgcttctgc acaacggatg gtcacgatcc 2941561 attctccgtc accggcatcg tcacaccatc cgaccatgcc ggtaaagaaa ccgcggtcaa 2941621 atggttcaat gctgagaatc gcttctcttg caagatcagt cggtgttccg cagacggctg 2941681 gcgtcgggtg gagcgccgcc gccaattcaa gtgcggttac agacgggtcg gaaagctctc 2941741 ccttaatcac gctggacagg tgccacatcg tttccgtttt gatcagtgaa ggcttctccg 2941801 gaacctccag cgtccggcag aaaggtctca gcgctgccgc aaccgcgtca gcgacaaccg 2941861 cgtgctcatg aagatccttt gcggaagaaa gcaattcagc tgcccggcgc tggtcttcaa 2941921 caggatcatt actgcgcggt cttgagccgg ctaatgggtt ggaaacgacc tgtgttccca 2941981 tccttgaaac gagaagctcc ggacttgctc cgagcaatgt tctgcgggga gacgtttcct 2942041 cctgactgga cacgtctgcg gcaaacgtgt agccatgcga gttatgctga gccagatggc 2942101 gaagcaattc atccgtctga atcggttcag gcgatgtcaa atgcagcgat ctggacagga 2942161 cgattttgct gagtgttcca tcggcaatgc gtgccagccc ttgttcaaca ccatttttat 2942221 aatcctcagg ttcaggaaca ggctttatgt ggtatgtatg cccagcctgc tgttcctttt 2942281 cctcatgatc aaattgaagc ggtcctgacc agcgcacttc ttcaggtaca acgagccgcg 2942341 ctgcttttac ttgatcaaaa ggaacggccc cgacaacaag cggccggctt tgccctgatt 2942401 gttttgcctg acgtaacgcc tctgcaattc ggccagaaag ggtttccatt tggttttgcc 2942461 cgtctgcctc cggtacaatt tcacatatgc ctttcgctaa cagtacacga tgaggagacg 2942521 ctaagaaaaa ggcgcccggc tgatattcat gaagcaaatg ctccgctttt gtttctgtta 2942581 taacgttttg atccaacatt ctcatgaacc tcctttaaat tcagttacac gcctaaggtc 2942641 gcgccgccat ctacgcataa attatgcatc gtaatatgcc ctgcctggcc agaaaccaaa 2942701 aagagcaccg catccgcaat atccgaaggc ttggctagtt ttttgagcgg gatccctgtt 2942761 ttaaatgtct caagtgatcc ttttatgact tgctccgctc cattctcgtc ggcccataat 2942821 gaccactgca tgtctgtttc cgttgatccg ggagatacaa tgttgcagcg aatattgtat 2942881 tctgcaagct caaggccaag gcatttcgta aacatcacag ccgcagcctt tgaagacgca 2942941 tatgccgcca tagatgttct tggtacaccg gcagcattcg atccgactgt tacaatcgaa 2943001 cccgatcttc ggtccatcat atatttgctg actgaacgcg aggcgttaaa tacgccagtc 2943061 gaattcactg agaacgtcgc ctcccattcc tcatcgctaa gcgaatggat cagtcccggg 2943121 cgaaggacac ccgctacatt cactaaaata tcaatcggcc ccatttcacg ttcgatgcgc 2943181 gccgtgatct cgtcaatcgc cgcgctgtct ctcacatccg caggaaaagc ttctgcatgg 2943241 cggccttctg ctttgaggct gctcacaacc ttttccagct tttcaggatt ataatcaact 2943301 gccgcaatat gtgcgccttg actggcaagc gtccgcgcaa cagcttcgcc tattccttgg 2943361 gcagcccctg ttataaaagc aatttttccc tctataccct ttgcattcat atcatcaatt 2943421 cctttcttcg ctctaaatgc caaacagaca tccagcgaaa aagactgctg cgccttgaaa 2943481 aacgcaatct attgataatg attatcatta tcaattataa aaataatcat atccaaatgt 2943541 catgtgacag tcaaatataa tttcagtgac aaatattttt ttaaaggcaa ggctgagtat 2943601 gtctcagccc attgatagat gcggtccgtc agggtgaagc gcaaaacgca gcgccctgct 2943661 gaccaaaaca ggaagaactg aaatatgtcc ttctcctgaa aactcgcaaa attctgcccg 2943721 tataccttgt tcagataaaa cggccagccg ctcataaagc tcccttgcat tatcattcat 2943781 ccggctttta tgatgctgct ctaattctcc tgcggcaagc aggatattga taggctgatt 2943841 gtttttcttg gtgagagaga cgaaatggtc cgttttcttg agaataaacg gtttattcca 2943901 atgaatggac ggacttcccg cgatatacgt ttgaaacgca tcgggctttg ttagcagcac 2943961 ctgcagcacg aaaagccctc cgagcgaatg gccaaagatt gtttgtcttt ttttatcaat 2944021 ctggtaatct cgttctatct ccggttttaa atcctcttca ataaatctga aaaagccctc 2944081 cgctccgcca tgctccggcc attctctgcc gtcgggcctt tccggcagct tcgattgggc 2944141 tgttggcatt gtaaaatccc ggtggcgtgc tgaggagaac ggctccgctg tctcatagcc 2944201 aatgccgacg atcactgcag ggatcacccc ggttttttcg ggtcggcgtc cctgtattcg 2944261 aacggcttcc gtcatcgttc cgaagacaga attggcatcc agcagataaa tcacaggata 2944321 accagcgggt ggcggcggcg tactaggttt cgagataaaa atgtgatagg tacggttttc 2944381 attgcgtgaa gacatcatac gcacttccgt accaggaatc gtaaatgcgt ttgatgtccc 2944441 gccatttgtc cggtctgttg tttgttcttt catgcagtac gacattcctc tccttaaact 2944501 aaaccgcaat gtatgataat gattttcact atcaactaga cacctcaaat aataggtttt 2944561 cttccaaaga aagtcaactt tttcccgaat aaaaaaggca ccttgatcaa ataaggtacc 2944621 tgcagactat caatatggaa gtaaaaacct aataaagatg cgtattgtcc tatttgaaat 2944681 agaaccttaa tcccatgtaa acctttgatt ttgccaaggg tcgcctctca tgtgatagcc 2944741 attccgctcc caaaagccag ggtgattttc tttcgtaaat tggatgccgc gcagccactt 2944801 ggcgcttttc caaaaataca gatgcggaaa tacaccccgc agcggaaagc cgtgttcagg 2944861 ggttaaaggt tcgccattat gcgcataagc cagaagggaa gtttccgcta agaaatcatc 2944921 aagcggcaga ttggtcgtcc agccctcttc agcatgtaaa atgacgtagc ccgcttcttc 2944981 ttttacaccc gctttttccg ctatatcaca agcccgcacg ccttgccaca cattatcaag 2945041 ccttgaccat cccgtgacgc aatgaatgtc gtttttcgat tcataccgtg gaaaggcttt 2945101 gacatcttca aagcttagca gcatcggatg gtcaaccaaa ccgtatactt gaagattcca 2945161 tttcgtcata tcttcgtaat atgggacatc tccggtatga agcacaggaa atgaagtggt 2945221 gacgttttga tttggcggca ctcttccaga ttgatcggac tgtcttgttt ttccgaaata 2945281 catatgggcc tcctttttgt taacctaatt taaaatcatg ttgacaatct ttttgttctt 2945341 tattactcta tgattgtgta tgtcaaccta agggggaaca acgatgaaac aacgtaaact 2945401 tcgtgcggga gatatggcgc tgattggcat gttcgccgca cttatggctg tcggggccaa 2945461 cattacatca gtagcaccct ttttacaagt agccggcatt ccgctttcga tgcagccgtt 2945521 tttctgtctc ttggcagctt tgcttcttgg cagcaaacgg gcagcgattg ccatgattgt 2945581 atatgcactt gtgggattgg ccggagcgcc tgtgtttgct caattttcag caggcttcgc 2945641 accgtttgca gggaaaagcg gcgggtttat tatctcatac attccggcag catttgcagc 2945701 gggatggttt ttagaacgaa acattcagcc aagtaaaatt cgatttctca ttgcttcact 2945761 tatcggaacg gcgatcatgt atctcatcgg cactacctat atgtatcttg cactgaagct 2945821 gtggattcat acgccagtga gctacggcac ggcttggggc tttatgattt ggtttatggt 2945881 aaaagataca gcgctggctg tgatactgtc gtttatcgca ccagcaatct accgctctat 2945941 tcataaagca accggcttta acagaaatca catatcatct acgtaaaaac cgttctattg 2946001 gacggttttt ttatcataac gagaaaaggc tccccagtaa aggggagcct ttttcctata 2946061 aaacaagcgc tgcaatccag ccaaagatga caagcggaat attataaaat ataaatgtcg 2946121 gcacacaagt atcccaaatg tggtgatgct ggccgtccgc actcaaacct gaagtcggcc 2946181 caagcgtact gtcactggca ggtgaaccgg catcgccaag cgcagcagca gccccgataa 2946241 tcgcaatcgt tgccatcggg ctgaatccaa gctgcatgca tagaggcacg aaaatggttg 2946301 tgataacagg aatggtcgca aaagaagatc cgatccccat tgtaattaat aagccgacaa 2946361 tgagcatcag caatgcgccc aaggactgac tgtgtccgat aaaaccagct gacgttttga 2946421 ccagtgactc gacatctccg gttttcgtca atacgtttga aaatccggct gcaacaagca 2946481 tgacaaagcc gataaaggcc attaaaacca ttccatcagt aatcagtgag tccgcttcat 2946541 cacgcttcat cacaccgctg acaaacagaa caatcagacc agcgagcgcc cccataatca 2946601 ttccttctac tcccaaagtc tgagataagt aaagctggac gccgagtgac acaacaatgg 2946661 ctagaaccgc gataccaata ctttttctcg tatatggcga tgcttctgca cctgaaatgt 2946721 cttttgtttc atattgtttc ggtttacggt atacgatcac tgataaaata aggccgacaa 2946781 ccatacctgc aactggaata atcagtgcgt acggaatatc agcaagcgga acgtttaacc 2946841 cggcatccgc catattgtcc ttcagcatgc cttggaagat ttggccgaaa ccgaccggaa 2946901 gcaaaatata aggagccgtt aagccaaatg taattacaca cgcgatcaga cggcggtcca 2946961 tttcaagttc attaaagatt ttcaaaagcg gcggaatcag caccgggata aacgcgatgt 2947021 gaaccggaac gacgttttgc gaaaaacaag atacaattaa aataatcagc acaatcagca 2947081 ccttagacag tgcttttttt cgagaatctt ctttatttcc gattaattta acggaggctt 2947141 ccaccattgc gtccggaaga cccgttttcg tcaaagcggc ggcaaacgcg ccaagcatgg 2947201 catagctaac tgcaacggtg gcatttccgc cgagaccgtc tgtgaaagct ttaaccgttt 2947261 cgccaagacc gagcccgcct gttaacccgc cggccaaggc gcctataatt aatgcgataa 2947321 caatattgac acgcagcagg cttaatacaa gcataagcag gactgcgatg acgactgcat 2947381 tcatgatgat acccctccaa aaatccttta gtttgctaat gtagtagata aataaagtac 2947441 gaacgtatcg tatcataacc gatccacttt agtcaactaa agatttcgga agaaaaaatc 2947501 cctgccgcat catacagcag ggatttttca ttactcgttt ttatcttctt ccaatgtaaa 2947561 tcgctccgca agtgtagcca gtgttcttgc cataacgcca gtagccccgg ccggtccgaa 2947621 gcaggttgct ttattggcag tcgctgtgcc tgcaatatca aggtgaaccc aaggtgttga 2947681 ctcagcgaat tcaccaagaa acgttcctgc cataatcgca tgtccctcgc gtcccggtga 2947741 attgctgaga tccgccattt ggctgctttt cacgcgtttt ttatccttct ctgttatcgg 2947801 cagctgccag atcgcctcgc cgcactcttg tgcagcatca gctacctgct ggtaaaagct 2947861 ttgatcattt gtcattgcac cggttgtttc tgttcctaat gccacaacga cgccgccggt 2947921 aagcgtagct acatcgacaa gaactgatgc gccatgctgt ttcgcgtatg taatgccatc 2947981 tgcaagcact agccttcctt cagcatccgt attaaggatt tctattgttt ttccgcttaa 2948041 agatacgatc acgtcatccg gcttcatggc cccgccggag atcatattat cggttgatgg 2948101 aataacgcac agcacgtttt gttcaggacg aagctctccg atcgtttcca tagccccgag 2948161 aaccgcagct gctcctccca tatctgattt catgccaaca attccagatt tcgttttaat 2948221 ggagtagccg cctgtgtcaa aggtaattcc tttcccgact agtccgacga cgtcttccca 2948281 ttcctttttg ccctgatatt tcaacacaat cattttcggc ggttcggtgg agccttggtt 2948341 taccgcaagt attccgccca taccgagctc ttccatctct gatttctcca atatctcaca 2948401 ctcaaaatca tatttcgccg caagctcttc agcatacgaa gcgaggtcag tcgctgtcag 2948461 catgtttccc ggcatattca caagcgttct agccgaattt gtcccttgtc cgtatgcctg 2948521 gccgacgcga agccctgcct gcacttcctg tgtatcttca tctgttacaa catacacggc 2948581 ttcaatttgt ttgtcaggct catttgattt atgcttataa tcctgcacct cataggaagc 2948641 aagcaggcag ctctcagcta aagcatgagc ggcatcggct ggaggcacgt cttccgaaat 2948701 aaacgtatca agcagaacag cagtttcttg ttttcgatct ttatgaatgg cttgaaaaac 2948761 atgagcaaaa cgttccttcg cctgttcaaa cgaataattt gcttctctcc ccaggccaac 2948821 gaaataaatc cgtttcatac ccgcagaaga tggagggaat acttttgata cttgattcgg 2948881 tttcgcagag acatcaccct cttttaaaag ctgtgtcaga tggccttcga gcatttcatc 2948941 aatttccaac gcttttcctg tcagctggct tttttgaaaa agcccgacaa caagggtttc 2949001 tgtatgctct gattgttgaa ccgcataaaa catgaggctt acactcctaa cgtaatgggt 2949061 atttgtaatg aacaatggta taataggaaa aacattcttt ccactatact tattttaaca 2949121 aacaacagtc taagacttgc ttttttcttt tgaaacacga aggatttttc aaatagaaag 2949181 gatgtcgccg atggaacttt taacgaattt tcctttatta tcaagcctgg ccgcaattat 2949241 ttttgctcag gtcatcaaag tgcccataca gtttatcgtg tccagaaaac tggactggtc 2949301 gctggtcaca agcacaggcg gcatgcctag ctctcactcc gcagcggtca ctgcgctttc 2949361 tacaggcgta gccttggagc atggattaga ctcctcactc tttgcggttt ccgccatttt 2949421 cgccgtcata accatgtttg acgcaactgg cgtcagacgt cacgccggtg agcaggcaac 2949481 agtcattaat aagcttgtta ttgattttaa ccgtttcgta aatgaagcga aggacttccc 2949541 taaggctgca gagaaagaaa agcaaaaaaa gctgaaagag cttctcggac atcagccgat 2949601 cgaagtcttt ttcggaggat taacaggtat tttactgaca ttggtactcg cttacttttt 2949661 catgtaaaaa aaacgctcct gctttcgctg gagcgtttta ttctttcacc gttttatatt 2949721 gatttctgaa cacttgcaaa gattttgttt cattgagctt ctcaagctca tcctcggtaa 2949781 tctttcccgt tcccttttta atcacatata catcaagggt ttttttgccc cattcattgt 2949841 atacatcttt gactgtctca aagtacagat caaggcggtt tcccttaata gctgatcctg 2949901 tgtcggccac aactccgaga ccgtagttcg gaatgaataa aattgttccg atcgggaaaa 2949961 cggacgggtc agcagcaacc gtggaatata aatcccgttt cactttcaca cctgaatatg 2950021 taagcccgta taatggatca ccgggatttt tgcccgtcga ctcagctcct gctgtgtagc 2950081 ctgttgctgt tactctttgg actggatatt catcccaatc aaatgcctct tctaacggtt 2950141 ttgttttatc ctcagccgcg gacgtggttt gtgtttgttt ctgctgcaat gcttttaatc 2950201 tcagtcctgc atgcttcaag tgcttttcct gatgttcctg cacccatttt gacaagtcct 2950261 tcgcttcaat tcctgacact gataaaaatg tcgtgccaaa tgcaagcaga aataaacagg 2950321 tcatcagcaa acgtctgatc atattcaaca tcattcacct ctcctccgaa tcattgttcc 2950381 caagtggaga gagcattatt caaaatggtg aatgagctga acgcataaaa aaagctttct 2950441 ttagaagaaa gcggcattta aaacatttga tatcctcttt ttctaagcat gttgatcgct 2950501 ataccggaca cgatggcgcc ggccaaaccg ctgactaaaa tcagcacatc agcagccgct 2950561 aatgataaga cacgatgaaa caggctggca aaggattctc ccggcgactg gacatagctg 2950621 atcagctttt ctttgctgat aatgaaaagg catacaattg gataaatcac agccataatc 2950681 caagacattc tcagcagcat gtttaataag aaaccgattc caaaaaacaa gacaaaaaac 2950741 aaaacaattg agatgattac gactggcaga ctaatcaacc tattccaccc ccctgcgttg 2950801 tttttagtgt aacgcggggg ctgaaataaa gtcaacggct ggaaaaagaa tgactgtctt 2950861 ttcctgtccc ctggcaagac ggacaagtct ctgaaccgcc gagaatcaat tgaaaatatc 2950921 ctttccctga acaaaatggg catgcatgtg aagcggttgt cgttgcagtt ttcatctaat 2950981 catcaccctt tttcttaatt ttctgataat ataccatatc aagctgtcaa caataaagtc 2951041 agatcatgtg acaaatcttt tgatgtaagc ggaaacatac ttgttttcct ctcgttctct 2951101 ttttattttg gcgtttttta ataaagaaaa cccgcttccg cgggttttta gaaaaacttg 2951161 aacttgcctt ttttcaatgt cagtccgagt ccgccaatca taaacagtga gcggttatca 2951221 atgacttttt tcataaacga agcgggcgtg cctttcagct ttctgccata aacaacccca 2951281 accgcgttat gctcgccaag agaagccact gttcccttaa tgtccggctt gaattcctca 2951341 agctctccgc ctttaataag cctgccaagg tttttagcga ccgttatgcc ctgctgcatt 2951401 gcaatttgcg cagtcggcgg atacgggcgc tctgtatctt cattcataaa cagcgagctg 2951461 tcgccgagaa taaagacatt gtcatgtccc ggggcgcgga gatcagggtt gactttgact 2951521 cggccgcgca tattctcaaa accggcttcc tccacaatcg gatggccgcg gacacctgcc 2951581 gcccatacaa cggtttgcga tttgatctgc tctggttctt catctttttt gccgactctg 2951641 actccttctg gtgtacattc ttgtacagcc gttccgatct tgaactcaac tccgttttcc 2951701 tcaagataat gtacggcgta atcaacaagt tccggatcaa agcccggcaa aacggtcggc 2951761 gctgcttcca cacaaatgat gcggacaagg cttctgtcaa cgtcatattc cttacagagc 2951821 tccggcacgc gagcagccag ttcgccaaga aattcaattc ccgtaaatcc ggcaccgcca 2951881 acaacgatcg ttaacctgtc cggccgtttt tccgcttccg tattgtaagt cgcaaactgc 2951941 agctcaatat gttcccgcag caggcgcgac gtgttgatgt tggcaatcgg aaacgcatat 2952001 tcttttaagc ctttaatgcc gaacgtttca ggcacggcgc cgagcccgat gactaaataa 2952061 tcgtactgca attctccatt cgcaagcaca acttttttct catcaatttt gattgccttt 2952121 acggtatcct gtacaaaatt cacccgtgac tggttgatta catcttttat ctgataacgg 2952181 cagcggtcat gatggagcgt acccgcgctc gcttcatgca tccatgtcgt ttcataatga 2952241 taattgtgtt tatttacaag cgtaatgtca gcatcattcg gcccgacata cttcgtcagc 2952301 cttgtcaccg tcatcaatcc gccatatcct gcacctaaaa tcacgatttt gggcttattc 2952361 aatgccatca catccacctt ctcttttttt gcttttgtta gacccataat aaaatcatca 2952421 tttgtgttag cttcagctta ttggcgggat tttatgaaat atattgaaaa gttttttgtg 2952481 aagtccttac ccgtagcact attatcatgt ttatccggct ggcccaagaa acattcagaa 2952541 aaagatcatt tcatttggtt attatcgtag cggcctgcgg aaatattttc aagaacggat 2952601 gggcacgtta gatccttacg attttttctg ctgactcgtc aatttgaacg gcaatatggt 2952661 ataattaata acaattttca tttaggaggc aattttcgta tgcgagagga tacaaaggtt 2952721 tatgatatta caattatagg cgggggaccg gtcggcttat tcaccgcttt ttacggcggg 2952781 atgagacagg caagcgtcaa aattatcgaa agcctgcctc agctcggcgg acagcttagc 2952841 gccctatacc ctgagaagta tatatatgat gtagcgggat tcccgaaaat ccgcgcgcaa 2952901 gagcttatca ataacctaaa agagcaaatg gcgaaattcg accaaaccat ttgtctggag 2952961 caagcggttg aatctgttga gaaacaagcg gacggcgtgt ttaagcttgt aacaaatgaa 2953021 gaaacccact actctaaaac ggtcatcata actgcaggaa acggcgcatt caaaccgaga 2953081 aagctggaac ttgaaaatgc cgagcagtat gaaggcaaaa acctccatta cttcgttgat 2953141 gatctgcaaa aattcgccgg cagacgcgtt gcgatccttg gcggtggaga ttccgcggtt 2953201 gactgggcgc ttatgcttga gccaatcgca aaagaagtat cgatcattca ccgccgcgac 2953261 aagttccgag cgcacgagca cagtgtggaa aaccttcatg cgtcgaaggt taatgtcctg 2953321 acaccattcg tccctgcgga gctgatcggc gaagacaaaa tcgaacagct agtgcttgaa 2953381 gaagtgaaag gcgaccgcaa agagatttta gaaattgatg acttaatcgt caactacggt 2953441 ttcgtttcat ctcttggacc gatcaaaaac tggggcctgg acatcgagaa aaattccatt 2953501 gtcgtgaaat caacaatgga aacaaatatc gaaggcttct ttgcagcagg tgacatttgt 2953561 acatacgaag gaaaagtcaa cctgattgcc agcggcttcg gcgaggcacc gacagcagtg 2953621 aacaacgcca aggcttacat ggacccgaaa gcccgcgtac agcctcttca ctcaacaagt 2953681 ctttttgaaa ataaataata aaaaaaggag cttgtgtctg cgacacagct ccttttttat 2953741 ttgaagatat ttatataatt caatgcagtt cctacaacca gcgcaatcac aagggctgcg 2953801 actacccaga tcattgccat aataatgcgg tcctgaatct tttgggactt cggtgttttt 2953861 tcttcgtttt gggccatctt attcgctcct ttcccatgtc catgccataa agaaagcctg 2953921 gtgctgaacg accaagcttt gctgaacgta tatcattcgc gttttgatcc gctctctaag 2953981 accattcgtt aaaactatga tacctaaact caccctgcat gacaagcttc ggcacttgca 2954041 ccacacctgc cagcaaatca taatgtttga catcctaaat aaaacagagt acattatata 2954101 aggcgaacat ttcatatatt atacttttaa atattcgttt ttaggagtga aaaccatgga 2954161 aaacgtattt gattacgaag atattcagct aattcctgca aaatgcattg tgaatagccg 2954221 ttcagaatgt gatacatccg tacgtttagg cggacataca tttaaattgc ccgtcgtccc 2954281 tgccaatatg cagacgatta tagatgaaaa actagcgatt tcattagccg aaaatggcta 2954341 cttttatgtg atgcaccgat ttgagcctga gacacgaatt gattttatta aagatatgaa 2954401 cgcacgcggg ttattctctt ctatcagcgt gggcgtcaaa gatgaggagt atgaatttgt 2954461 ccgccagctg gcagaagaaa atctgactcc tgaatacgtg acaattgaca ttgctcacgg 2954521 gcactcaaat gctgtcattg aaatgatcca gcaccttaaa aaacatttgc cggacagctt 2954581 tgttattgct ggcaatgtcg gaacgccgga agcggtcaga gagcttgaaa atgcgggagc 2954641 ggatgccact aaagtcggca tcggaccggg aaaagtatgt attacgaaaa tcaaaacagg 2954701 cttcggcaca ggcggctggc aattagcagc gctgcgctgg tgtgccaagg ctgccagcaa 2954761 accgattatc gcggatggcg gcatccgcac ccatggcgac atcgcaaaat caatccgatt 2954821 cggcgcaacg atggtcatga tcggttcact atttgccgga cacgaagaat cgccaggcca 2954881 aacgatcgaa aaagacggaa agctttacaa ggagtacttc ggctcagcct ctgaattcca 2954941 aaaaggcgaa aagaaaaatg tcgaaggcaa aaaaatgcac gtggcgcata aaggctcaat 2955001 caaggataca ctgattgaaa tggagcagga tcttcaatct tctatttctt atgcaggcgg 2955061 aacaaagctt aacgccatcc gcaatgtgga ttatgtgatt gtgaagaatt ccatttttaa 2955121 tggggataaa tattaatcat aaaaaaacgc caagtcagcg gttctccgct tgagttggcg 2955181 ttttctgcta cttcttcagc aaagtaagct tatatttgct ttttgagttt atcttccatc 2955241 agttctgcca tttgttttgc atttggattt tcttcatttt gcaactgttc aatgacgttc 2955301 atataatccg tttcatttcg gttctggctt aatttatatg ccgcttgaat gtcttccacc 2955361 ttaatcttaa atccaacaat acctttcaat tcactttcta agagttttgg agaaagctta 2955421 tcccataaca caggattgtc acgatgtttt tcgtatttct ccaacatgat tgttaattct 2955481 tctgctaatt catctttctc taacatactt gcttttccat acatgtggac agcctgataa 2955541 ttccacgtcg gaacattttc gcgcgaatac caggaagaag aaatataagc gtgcggtccc 2955601 tgaaacatca caagcacatc ttcacaggct tcaaacgttc tccactgagg atttccataa 2955661 gcgaaatgcc ccgtaatata gtaatgatcg tcttttttat tgaatcctaa cggcaaatgt 2955721 gtggcaattg gttttccttg ttctgttgtg acaaccgtac caaaggagtt ttcttgtaca 2955781 aaattccaaa tttcttcagc atttgtgact ttaaaatatt ttggaatata catcatcatc 2955841 cacccttcga aaaatattat atgagtgttt tagccatgat taaatccgtt tgttcttcat 2955901 cacccatata aaatgagtgg gcgccggtct gaacaaaccc cattttctta taaaaggcaa 2955961 tggcattttc atttttttcc cacacaccta gccaaatgtt ctttttatta cgttccagcg 2956021 caatttctat cgctttattc agcagatgtt tgccaagccc atgtttttga aagctgttct 2956081 ttatataaat tctctcgatt tcaagtgatt cagcacccat ttcttcagac tgagcatcat 2956141 cgatattgac ctttacatat ccagcgattt catgatcaaa gtaaataaaa aagaattgcg 2956201 aagacatatt agataactct ttttccagct gctcagtgtt aaatgcgctt tctaaatagg 2956261 ctttcatatt ttcaggtgag ttctgttctt taaaagtgtc attgaatgtt tcaatactca 2956321 attgttgaag tgtttgtaaa tcttcccggc tgcatttttt catttttaca ctcattgttc 2956381 ggattcagcc cctttattta aaattcaatt gtcttgtgtc ccttttatat atttaaacac 2956441 ggaacacata ctgaccttgt taccattcca aaaatcttct tcatcaccaa ctccctatcg 2956501 tgattttgtt gtaaatgcaa taaaatatac tccgcattaa atatatcgta actttgctgt 2956561 atttacaaca aaaatcaaac aacaaagcag cgtttctctt gccgaagttc ccggaactct 2956621 ctgcatcatt tccccataat aaaaacgcct cccttaacga tgatttatcg ctaagaaaag 2956681 cgtcagtaat agttgctatc cgtttttagt gcttagcact cttcaggctt gcctgcattc 2956741 gttgctgttc tgaacgaaga accgcagccg catgaagcga tggcgtttgg attgtcgatg 2956801 gtgaagccgc cgccgagcat ggattgttta taatcaatca cggtgccgtt catgatgtca 2956861 aggctttctt tgtcaactag aacagtgatg ccgtgctgat caaacacact gtctgattca 2956921 ctcttttcat gctcaaagcc catgccgtaa gaaagtccgc tgcagccgcc gcctttgacg 2956981 cctacacgca gaaacgcgtt ttcttcttca tgctctttca tcatatcttt tatatgcaaa 2957041 gctgctgctt ctgtaattgt taccgggttg ctcatcatta tgaacctcct tttaaaaacc 2957101 ggttgctgtc ttttattata aacatgatcg ttccaattct caaacaaggt gttttacaag 2957161 aaatagacac cctcacaaac ggtttcagcc ggccctgtca tcattacatg gccgttatct 2957221 ttccagttta tcaccaaatc cccgcctgct aaatgcaccg tgatgtcttg atttcgcttt 2957281 gatacgccgt ttaatacaga tgcgactgcc gctgcacatg ctcctgtccc gcatgcctga 2957341 gtaatccctg atccccgttc ccagacgcgg aaatgcaatt cttgttcatt cacggtttca 2957401 acgaattcca cattgatgcc ttccggaaat ctcggatctt tctcaatcac cggccccagt 2957461 gtcgttaagg gtgcctgttc aatgtctgcg atcggaaaaa cgatatgcgg atttcccatt 2957521 gaaacggcag tgcctgttag ttctacttca ccaaatgcca tcgtttcatt gattgtgtgc 2957581 tcttccccgc cgtcaagcat aggaagctcg gattttgtca agcgcggttc gcccatatcg 2957641 acagtgacca cattcacttt tccgttttcg acttgaacct ccgctttcac aagcccggag 2957701 agagtttcaa tcagaaaaga tgtttcctca accagcttat gctcatatgc gtattttgcg 2957761 acgcagcgca ggccgttgcc gcagtttttc ccttcagacc cgtcattatt aaaaatccgc 2957821 attttaacag gcgcttggtc tgatgggcat atcaggatca ttccgtcgga tccgatccct 2957881 gtataaacag aagaaacctg aattgcaatc tctgacagtt tttcttctgg aagctgttct 2957941 tcaaattgat tcacataaat ataactgttt cccaggccgt gcattttggt aaatcgaaat 2958001 gagttcatag gtgcctccaa ctttttttct ttttcttagt ataaaagcta ttataagcgg 2958061 acacaataca attatccccc gtttttcata cataaaagct ccttgcactg acgcaaggag 2958121 cttttatcgt ttatataaac atgccggcaa tggctgcgct gagcagattg gctaatgttc 2958181 ctgcaagaac agccttcagg ccgagacgtg cgatatctga acggcggctg ggcgctaaac 2958241 cgccaagcgt accaagcata atcgcaattg atgaaaaatt ggcgaatccg cataacgcga 2958301 aactgataat ggtagcagtt ttcttagaaa actcgccgat gtgcgaaccg aagttagaat 2958361 aagcgacaaa ctcattcagc accaatttct ggccgatata gcttcccgcc tgcaatgctt 2958421 catgccaagg cacgccaatc aaaaaggcga taggagaaaa cacatagccg agaatggatt 2958481 ctaatgttac gccttttaaa ccgaacaagc cgaaagcccc gccgagaata ccgtttacta 2958541 cagcgattaa cgcaacaaac gcaagcagca tcgccccaac atttaacgca atttgcagtc 2958601 ctgttgacgc tccctttgca gctgcgtcaa tgacattggc tgcgccttcg ccttcatcca 2958661 ttttgaaatc gctttttacg gtttgcgttt tttccgtttc gggtataatc aatttaccaa 2958721 agactagtcc agctggagca gccataaagc tggccgccag caagtactca atcggaatac 2958781 cgagaagcgc gtacccaaac aaggtagatc ccgcaactgc cgatagaccg ctcgtcataa 2958841 tcgtaaacaa ctcagagcgc gtcagcccgg caatcagggg tttgatcact aacggagatt 2958901 ctgattgtcc tacaaaaata ttggcagcag ccgccagaga ttccgttttg cttgttccaa 2958961 ggagcttcga caatccgccg ccaatgacac ggaaaacgag ctgcatgatt ttcaaatgat 2959021 ataaaactgc aatcagtgct gagaagaaaa tgataacggg cagtacactt aatgcaaatg 2959081 ccggactgtc tccgaccttt agaagcggtc caaaaataaa actgatgcct tcattcgcat 2959141 agtcaatcag aagctgtaca cggcttgaaa accataaaaa aacagcgcgt cccgcttccc 2959201 atttcaacac gatgtatcca aacgccacct gtgtgcataa accaacgatg acggttctta 2959261 tcttaatatt gcttttcttt tctgaaaata aaaacgcgat agcaatgatc gcaactgcgc 2959321 ccagcagccc ccacagaaca ttcatgaata ctcgtacacc tcttaaattt tatttaaaaa 2959381 aatatctttt atacgataac aataatattt tttgatgtct acacattttt ttagttcttt 2959441 tgtacggcaa aataaaaaag ggcctgtcca ggcccttttc tttaaaacat tggattttct 2959501 tcaataaagg tatatatatt ctcaacaagc tcagcaggcg tttcacccat gacgacttct 2959561 ccgtttacca gagcgaaaag cgattccata catgtcccgc agtagcttaa gcagccatat 2959621 tcaaggacat caaggttggg atccttctcc aaaatcgccc gggcttcctg agagccgtga 2959681 gccagattgc tgacacaaaa ttcaatcatt ggattcatgc ggtttcacct cacatatgtc 2959741 cattatcgcg aatttttcac tattcgtcaa agacaacgga tgattcaaaa tttattatcg 2959801 taacatatta tttctcaaat aacgttttac taatttgtgt tttcaggcta aattgtaggt 2959861 tattttgaaa ctattattgt gattttagat caaattcgat ataattctag atgttatttt 2959921 acatagttcg tattttcttc aatgtatcta tcatactctt cggattaaag gggaattcaa 2959981 atgaaaaaat tggtcttgat cggcggaggt tacgggaaca tgcgcgttct tcatcgctta 2960041 ttgccaaacc agctgcctga tgatgtttca atcacgttaa ttgacagaaa tccttatcac 2960101 tgcttgaaaa cagaatatta tgcccttgcc gcaggcacaa tttctgacca tcatatcaga 2960161 gtgtcattcc cagagcaccc tcgcctggat gtccaatacg gtgatatcac atcaattgat 2960221 attgtacaaa aacaagtgct gttccaagat cgtgaaccga tttcttacga tgacgccata 2960281 atcgggctcg gctgtgagga taaatatcac aacgtgccgg gagcgcctga attcacctac 2960341 agtattcaaa ccatcgatca gtcccgcgaa acctaccaaa agctgaataa tctgagcgct 2960401 aatgccaccg tcgccattgt cggagcgggc ttaagcggcg ttgagcttgc aagtgaattg 2960461 agagaaagcc gtgatgacct gaacattatt ttgttcgacc gcggtaatct cattttatca 2960521 agctttcccg agcgtttaag caaatatgtg caaaaatggt tcgaagagca cggtgtccgc 2960581 attattaaca gggcaaatat cacaaaagta gaagaaggcg ttgtgtataa ccacgatgat 2960641 ccgatttctg cagacgccat cgtgtggaca gccggcatcc agccaaacaa agtcgtcaga 2960701 gacttagatg tggagaagga cgcacaaggg cgtattgtat taacgcctca tcataatctt 2960761 ccaggtgatg aacatctgta cgttgtcggc gattgcgcca gtcttcctca tgcaccgagc 2960821 gcccagctgg cagaggctca agcagagcag attgtccaaa tcttgcaaaa acgctggaat 2960881 ggagaagccc tgcctgaatc aatgccgcag tttaagctga aaggcgtcct cggttcactc 2960941 ggaaaaaaag ccggcttcgg gcttgttgct gaccgtccgc tgatcggccg tgttccgcgt 2961001 atgctgaaat ccggcttgct gtggatgtat aaacaccata acggttaatg atagagaaga 2961061 accgctgatc aagtcagcgg ttttctgtat acccatgctt ctccatttcc tcataaacgt 2961121 cttttaattt tggattgcct tcaccgacaa ttttgtcttc tacaagcaca agcggataaa 2961181 aatactcgtc atttctgatt ttttccgcaa gctctttcgc atgttcattg tcaggcggct 2961241 catgaatatc gatgtactgc atctcaaaag gctgatttgg atattttctt ttcagcgcag 2961301 cctcaagcca ctcgtatgta tccttggctg tcggcatatt tacacagctc gcacaaacgt 2961361 tttctgcccc gtacacgctt agcatgactg gtttcatcac ttgtagacgc ccccttctcc 2961421 tatgtaagtc ctttctttta agtatacaga gcctaagggc gtttttatag aaaaaaaccg 2961481 tttttgtgtt gaagtctgaa tgtgctataa tagggaaagc aactttgcaa accaaacaat 2961541 agatttttat tgttacactg aatataatgg ttttatgacg acgaaaggag cgaatgtcat 2961601 gactgaagtt gaaatgaaag aacaggtgca ggaagtactg gacaaacttc gtccgttttt 2961661 acttcgtgac ggcggtgact gtgagcttgt agacgtagat gaaggtatcg ttaagcttcg 2961721 tcttctaggc gcatgcggca gctgcccaag ttcaacaatt acgttgaaag ccggaattga 2961781 gcgcgctctt cttgaagaag tgccgggtgt cgttgaagta gaacaagtct tttaataaag 2961841 cagccaggct gatatttgat cagcctggct tttttattag agatgttgat caaaccatga 2961901 gctgatataa ttcaggcgct tgatccgctg tcttgggtgt ccggtgcgtg ataaattgtg 2961961 cgatgcattc ggaaaacgga caagcttggt ttccttgccc atttttttca gagcgataaa 2962021 cagctgctcc gcctgctcga tcgggcatcg gtcatcccgc tcgccatgca gtatcaaaag 2962081 cggtgtctcc acgtttgctg cgtattttaa aggagaccgg tcccagagct tttctgtgtc 2962141 ctcaaacatg tcatgctcaa gctgccagtc tgtaaagaaa tagccgatat cactgacgcc 2962201 gtgaaagctg atccaatttg atatcgagcg ctgggtaacg gcagctttaa agcggttcgt 2962261 ctgcccgacg atccagttgg tcataaaacc tccgtagctt ccgcccgtga caccgagccg 2962321 cttaggatca atatgcggat ctcgtttgat agcctcatcc acagcctgca tcacatcgtc 2962381 ataatccttt cccccataat ctcctctgac cgcattcaca aattcctgcc cgtagccgtg 2962441 gcttcctctc ggattgatat aaacgaccgc gtatcctttc gccgccagca cctgaaactc 2962501 atgaaaatat gtatgtccgt acatcatatg cggaccgccg tgtatgttaa gaataagtgg 2962561 atatgttgtc tcaccttcca tttgtgcagg cctcatcagc cagccgttca ccatcacgcc 2962621 gtcttctgta gcatattgaa tctcttcagg tattgatatc gtatgctccc tgacaaactt 2962681 gtcattcgcg ccagtcagct gtttctcttc ctgtccaagc gggatactgt aaagctcact 2962741 cggtctgtcc ggctttgtca cactggcaat aaagtgctgt tcatcaggtg aaagagaaaa 2962801 gctattgatg tactcttttt ccagacgaat cggatacaca aggccttcaa tcgaaatata 2962861 atagatgccc gtactgcctt gatctgtgcc gatgacataa aacccttggc tgtcctttgt 2962921 ccaaatcggg cgctgttcag caccaccgat caatgaatct ccaatcagcg catccgctaa 2962981 atgaacgtcc agcatctcag taagacatgt gaggcggcct tgttcgatat catagagcca 2963041 cgcctttgag agcgtagcat tcttatattc cttttcattt ccaagcaaag caagatacct 2963101 tccgtctggt gaaaatgagc ttgatccgaa tgagccgcga tgaggtgtaa cctgcttaag 2963161 atctccagac tccagtgaca ttatgtaaac atcatgcggc ttgctggcat catctgtttc 2963221 agttaaatta gctgagaaaa caagccattt gccgtcagga gaaaaagcag gatcaccatg 2963281 atcagctttg tgacttgtca gctctttcat ctcacccgac tttacgctga caagcacaag 2963341 ctgggcatac gcacctctcg tcagcccttt gccgtcccgt ttgtaggaga ggccttgcac 2963401 ttcaacaggt tcatagctgt cctgctctgt tttttctcgg tcatcaatgc tttccccctc 2963461 tcccaaactg acagtgacca gaatcgattc accgtccggg gaccatagcg gctttgacac 2963521 gccatatggg atatcagtca gttttcttgc ttctccgcct tcagtgctca tgatataaag 2963581 ctgtgccgca tcgccttctc gatcagaaat aaaggcaagc gtgcgcccgt ccggagacca 2963641 tcttgggtcg gtgcttcgct tttctccatg tgtccaagga acagatcctc ccgttttcgt 2963701 ttcatagatc catatatttg atgtatacga atctttctct tgatttactt gtgattttac 2963761 atatgcggca cgggtaccgt ctggggcgta ttgaggatcg gtcacagaga caatcgctgt 2963821 gatgtcgtct gcggttatca gctttttcat attcatctcc tcctttttac atgtatttcg 2963881 tttttctaaa taaaaactcc tttatctcca gcaaaaaaaa gcgccctccg ctgacgctga 2963941 ggaacgcttg gcatgatcta tacacttttt acttgatata aaggatttcg ctctattata 2964001 cttccctctt tcggaacggt caaagcgtct acttcacaat gagggaaatg aagcgcgagc 2964061 tgttctttta gctcttctcc ctttcctttt tcggtcatga cgagaatcgt tgggcctgct 2964121 ccgctgagag ccgttccata tgcgcccttc atctcggcga cgtgctctac ttttgacagc 2964181 tcaggcacaa gcatcgcccg gtacggctga tggaacatat ccttcttcat gattttcccg 2964241 acaagcggcc aatccttgga catgatcgca gcaatgagga tattgctgac agcacttgct 2964301 tttacggcat cggcatatgg aaactccttc ggaagcacgt ctctcgcgtc tcttgtcagc 2964361 acttcataaa aaggaatgac aacgactacg tcaatgtcag cattcgggac gcggatcatt 2964421 tgggtctcgt catcctcatg caggccgatc acaagtccgc cgacgagaga agcgccagca 2964481 ttgtccgggt gtccttcttc tagactcgct aaatgcagct tgtccgcttc agacagcttt 2964541 aagccgcata attcatcagc cagttcaatg gccgctacaa tcgctgcggc gctgctgcca 2964601 aggccgcgtg caagcgggat gtcgctccac accttcacat ggacaggagg catttctttt 2964661 ccgtacaaat ctgcggtccg tttagccact tggtagatca ggttatctgt acccgccgga 2964721 attccggcga ctgtttctgt ttcagcctca aaagaccatt tgtcgctttc aaagacggtc 2964781 agcttcaaat atctgctgag cgccattccg actgaatcaa agccggggcc taggttagct 2964841 gtgcttccgg gaacagtgac agagaacagc atgtcggctt cgttcataca cgggccgctc 2964901 cttttacata ttcaaggatg ctgtcttcat cagtcggcaa tgtgacaggc ttgatttctg 2964961 aaatgtcgac cgctgtgttc ggatctttca gtccgtttcc tgttaacaca gctacgacct 2965021 tgctgccttt cggaatttct ccggatttca cctgtttcag cactcctgcg atagacgcgc 2965081 aagaacctgg ttctgcaaac acgccttcta cacgggcgat cagctgatat gcgtgaagga 2965141 tttcatcatc agtgacttcg tcaattttcc cattggattc ctcggctgcc tttacagctt 2965201 tgtcccagct tgccgggttt ccgatacgaa tggctgtcgc tattgtttcc ggattttcaa 2965261 tcacttcatt gcgcacgatt gccgccgcac cctcagcttc aaagccgcgc attttcggaa 2965321 ggcctgtgcc gtttttctca tgatattcct tgaagccctt ccagtacgca gtgatgtttc 2965381 cagcatttcc gaccgggatc gctaaaacat caggcgcttc ccccagctgt tcgcacactt 2965441 cgaaggcagc agttttttgg ccttcaatgc ggtaagggtt gactgagttg acaagggcaa 2965501 tcggtgattt ctcacagatg gaacggacaa ttttaagcgc atcgtcaaag tttccgtcaa 2965561 ttgcgataat ctcggctccg tacatgacag cttgagcgag ttttccaaat gcaatttttc 2965621 cgttcgggat gatgacaatg catttcatgt tagcacgggc tgcatatgct gccgcagcag 2965681 cggaagtgtt acctgttgac gcgcacataa tcgtgtcatt gccttcttct tttgcctttg 2965741 ccacagccat aaccattccg cgatctttaa atgatcccgt aggattgacg ccttccgttt 2965801 tgacatgaag ctcaattccg agctgctcag acagcttcgg caggtgaata agaggtgtgt 2965861 ttccttcatg taaagttagc gccggtgttt gatctgttac aggtaaaaat tctttatatt 2965921 gatggataag tcctttccac attagctcca accgttccct tctacacgat atgtgctttt 2965981 gacttcttga acgacttcca aatcatttag gttttgcagg atatcactga aatcagcttc 2966041 tgatgtatga tgtgtgacaa ttacgatttc agctaactca tcatggcctt taattggcag 2966101 ctgaaggatt ttttcaaagc tcacgccccg ctctgagaac acagatgtaa ttttcgagaa 2966161 tgaaccaacc tcatctttta catgaattct taaaaactgc tgtgcataaa tgtcagacgg 2966221 cgatttcatg tttttctcat attgcggtcc gacaaagctg ttgccggtta cacctaggcg 2966281 catatttttc atgacagcga cgaggtcaga aacaacggat gtcgctgtcg gcatgcttcc 2966341 ggctcccggc ccgtagaaca tcgtctcacc gacagcctcg ccgtatacat aaacagcgtt 2966401 aaactcatta tgaacagcag aaagcggatg atggtcagga agcagtgtcg gctgtacgct 2966461 gacctcgatt ttgctgccgt cacgctgagc aatcccgatc agcttcattg tatagccgag 2966521 gcgtttgctg aagctgatgt cctcgtctgt aatttgggag atccccttta ctttgacgtc 2966581 ttccagatcc acgttcatcg agaagccgag gcgcgccaat atcgccattt tccgtgcggc 2966641 gtcaagccct tccacgtcag aagtcggatc agcttcggca aaaccgagat cctgcgcttc 2966701 cttgagcact tcctcgtatg ggcttttctc tttgatcatt ttggttaaga taaagtttgt 2966761 tgtgccgttc acaattccca tcatttttgt aattcgatct gatgagaggc cttcctctaa 2966821 cgtgcgcaga atcggaatcc cgccggcaac actggcttca aagtagatat cgcatccatt 2966881 ttccttcgct tcggcaagca gctcggagcc gtacacagcc attaagtcct tgtttgctgt 2966941 gacaacatgc tttttcgatc tcagcgcgtc gaccaaatat tgttttgtct gttcaacgcc 2967001 gccgatcacc tcgatgacga catcaacatc tggatcatca atgacatcat acacttctgt 2967061 cgtgagcact tccttcggca aatctacttc tctctttttc tctaaatctt ttacaagcac 2967121 tttttttatc gtaaccggac agccgacctg atgcataagc ttatcctgat ggtcttgaat 2967181 aattttaacg acaccgcttc cgacggtacc taaacctaaa agccctacac gaatcgcttt 2967241 caaaaaaact ccacctttct tttgattgtc ctcttggaaa agacaattgt taactcaaca 2967301 cagacatata agttacaaac attatataag cccgctcctg ttttgacaag acatcattag 2967361 gctgaatttt gcgaatgtaa acgcttaacg cattgatatg acaagattct ttattttcta 2967421 attatttttg tcagattttc tcctcacctt gagctgcctt tgccgagcca gctgacgcgt 2967481 ggaacaaaca gcttctgcgc ccgcatattc atgaattcct gcgctgtatt gagaaattgt 2967541 tcataacgcc cacagtcatt aagaatgaag tcaagctgtt cttcaaaata atgcttttct 2967601 gattctgatg acatgtaata gctttctacg atttcaaaat aatgaagcgg gaaaagcaga 2967661 cggctgtata aaaggcgttt cgaaaatgaa gacagcggtg tgacttgctc gtattcctgt 2967721 aaaaagagaa agccctgctg attaaaatct tgtctgtgat gcaaaaacgt atgcctcata 2967781 tattcagcca aatcacggga agcgtggtca aacacccaat ccgccggaat cctgatcaat 2967841 gattccggtg accatgtatg cctttccatc cgctgatggc atatcgttcc tgaatcagcg 2967901 gcttggggct tgtcatccag ctcagtgtcc actaaatatt gtatcgcgtt ttctgacagt 2967961 cctaaataat atggaaatga ttcgatcatt tttttatcga atggctcatg cggaggggtc 2968021 tgaacctttc tctgccaaaa tgcttccagc tgatcaattc gttttcccca cagatccttc 2968081 cactggccga ttcttccggc cgccttcacc tcatatggat atcctcggcc ttttcggtga 2968141 aattccgcaa gctccgctcc aatggagaac gccctgtttg aataaggggg ggccgccttc 2968201 agcagagcgt acgtttttcc ctcatgttca aatgtcagtt caccttcttt tgtaaagata 2968261 aaaaccgaaa cgtatgggtc actttgttct tgtaaatact gactcatgta ataaagctcc 2968321 gccagctctg tttctgagaa ttgggaaacg gggacaatca gaaagtatga attaggcgtc 2968381 tgaaagcatt gatatgtgtg ctggtacatg gaaagctgcc tgatgtgaat gccgtatttt 2968441 tcttttattg tacctttcac catgatcacc tgcctgttga attagggctc atcacatcgt 2968501 agtcatacac agccggaatt atgaatacat attttaatcc gaagaaggcg caagaaaaag 2968561 tcgtaaactt ctcaagcatt ttgtataaac tagtaaaaaa gattgggtga agctgatgtc 2968621 agaaaacgaa caattcagtc agatggaagc taaagcaaga gcacggatga aggagcgcgg 2968681 cgttgaggta tcagacattg ccgagcttgt cttttttctg cagaaaaaat atcatccgga 2968741 tttaaccatt gatgaatgca cgctgaacgt caatcgtgtt ctcgcaaaac gcgaggtgca 2968801 aaacgcgatt ttaacgggca ttgaattgga tgttcttgct gagcagaaaa aattgtctga 2968861 accgctgcaa acgatgctgg aaatagatga aagcctatat ggagtagatg aagttctggc 2968921 attttccatt gtgaacattt acggatcgat cgggtttacg aactacggtt acatcgacaa 2968981 agaaaaaccc ggaatcctta aacgattgaa tgataaatca accggtgaat gccatacctt 2969041 tttagatgac atcgtcggag cgatttccgc cgcggcttca agcagacttg ctcaccgcgc 2969101 gcggcataca gaataagggc acccttttag ggcgcccttt tttcaaatgt atggaatcca 2969161 ttcagtcaga gagtcaatgg cgtgagtcgg tttttccata tcgtctgtca tatgttctct 2969221 tttcgttacg cctgtgtgaa cgagcagcgt atccataccc gcgttaatgc cggccataat 2969281 atcagtggcg tagttgtcgc cgaccatgag tgtttcagac acatctgtgc cgagaacgcg 2969341 catcgcctgc tccataataa ttgattccgg cttgccgata aatacaggct gtacacctgt 2969401 agatacggtt aacaccgatg tcagtgagcc gtttcccggc aggagccctc tttcagtcgg 2969461 aatcgcaata tctccgttag tggaaataaa gcgggcgcca tttctgattg ccaggcagcc 2969521 aacagcaaat ttttcgtatg taatggaacg gtcgatgcca acaacgacaa aatccgcgtt 2969581 ttctccgcca aatgtcaggc cgttttcttc aatcgcctgg cggattcctt cctccccaat 2969641 cacatacaca gacgcgtctt ttttctgctg tgcaatgtgc tgggcagttg ccatgctggt 2969701 cgtgaagacc tgctcttctg ttgccggaat atcaaaagac acgagcttgt ccgctacctg 2969761 cttcggtgtg cgcgaagagt tgtttgtcac gaaaagataa ggaacgccgc gatctttcag 2969821 cgttctgaca aattcacacg cctcctcgat tttttccgtg ccattgtaca tcgttccgtc 2969881 taaatcaatt aaataccctt tatatgtttt catatccaac actcctgtgg ctttccagtt 2969941 gttatttaaa cgcggaaaca ggtcctagct ctgtttccaa atagcttctg atccgtttcg 2970001 ggaagtcctg aagagctgtt tgatgcgcct tgatcagcct gtaaagctcg ccgctgtcag 2970061 cgagcagata ctgttgaacc aacgttttgc ggtaggcgat caattttttg agctcatcac 2970121 cctctttttc cgtgacaact ttctcatcaa caagtatatc cataatgtcg tcatagctgc 2970181 ccgggtcccg cataataaag ccgtcaatca tgtcattgcc tgtatccaaa atgcattcga 2970241 ttaacagatg gcctatacgc tgaagtgcca attccccgat ttcagactgc cagtctgttt 2970301 gtgagtcaaa tagcgccagc tggtgctcga agaaccctag tgttttttcg attttgcttc 2970361 tgtcaacaaa atacatgaca gcatcccctt tgtgtatatt tattttctga tccgtttcaa 2970421 gacaaaatac gcacagccga aattgcagta ttcgtaaata tattcatcta atgtgctgat 2970481 tttcgtttcg aaggttgcct tttgattctg gtcgtcaaag aagcccttga gccttaactg 2970541 accgtatccc cagtctccca caatataatc gtatttattt aatatatcgg agtagcgggc 2970601 tttaaaagcc tcttcgttga agccgtcttt gaaattgtgc accaattcaa attcggcatt 2970661 ttgaataaga atcatgatct cacctctttt ttcactcatt cctatcataa ttcattgccc 2970721 cgtccccatc aattgctaaa gaataaatca tgcgatttgg ctaccctaca catgaggagg 2970781 gattgataaa tgaaacgaac cgctgtcagc ctctgcctgc tgaccggact attatccggg 2970841 tgcggaggcg caggattgga taatgcccaa aatgtccgga atcagacgca gaatcaaacc 2970901 aaacccattc atgtgtcgga ccgcaacgag gcttttaaca ggcataatga gaacgaacaa 2970961 tttggctatg tccgctatca aaaagaacaa tttgacggag aacagcagaa aacgccggtg 2971021 atgaaccggg aagaaaccgc tcacatgata tcaagtttaa cggttcagct cccccatatt 2971081 caagatgctg cgacattggt gactgaccga gaagcgcttg tcgtatacaa aaccgattct 2971141 aaaaaccggg agctgaccgc cgatcaggtg aaaaaaacag cggcttctgt gataccgcga 2971201 tactatcacg tgtatatttc cgataatcca aaccatatgc aatccgtcga aaattacagc 2971261 aatctcggct ctggttcaag ggatattaga gagatcatgt cggggacgat tcaagaaatg 2971321 aaaacctccc cgcaaggaag ccctgtctca gagaatgaaa atgccaatgg agaaacgcgt 2971381 caggacatga aaatcgatag gaatgacaaa aacgccagat gatctggcgt tttggcatta 2971441 tgcttgtgct tgacgctttt tagatgcttc gtttacttgt tcatccgcat ggtaagagga 2971501 acggacaagc ggaccggctt cacaatggct gaagcctttt tgcatcgcga tttcttttaa 2971561 ttctgcaaat tcatcaggat ggtagtattt ttggactttc aagtgtttct tcgtcggctg 2971621 cagatattgg ccgattgcca taatatccac gttgttcgcc aagaggtcgt ccattacttc 2971681 aataatctct tcttttgttt cgccgagtcc gatcatgata cttgattttg tcggaatgtc 2971741 aggctgcatt tccttcgcac ggcgcaaaaa ttccaatgaa cggtcgtacg tcgcacgcgc 2971801 gcggactctt ggcgtcaggc ggcgaaccgt ttcgatattg tgattcagga tgtctgggcg 2971861 tgtatccatc aaggttttta ggttatcgta gtttccgccc atatcagacg gcagcacctc 2971921 aattgttgtg aacgggcttt ttctgcggat cgcacggaca gtttccgcga aaatgcctgc 2971981 cccgccatct ttctgatcgt cacgcgcaac agccgtaatg accgcgtgtt tcaaattcat 2972041 aagcgcgact gaatccgcta cgcgttccgg ctcttgcaga tcaagctcag ttggaaggcc 2972101 tgttttgaca gcacagaaac ggcatgctct tgtacaaaca gaacctaaaa tcataaatgt 2972161 cgctgtacgt ctgaccgccc agcattcatg aatattcgga cactttgctt cttcgcatac 2972221 ggtatgcagg ttgttttccc gcatgagttt tttgagccct gtatagtttt catttgtatt 2972281 taatttaatt ttaagccatt cgggctttct gaggtgttcg tctttctttg ccaattccca 2972341 tcatctccaa tatccaatat actcaatttc tgacacgaaa cattctgaaa acgagaaagg 2972401 tgcaggtttt agttctgcaa caaaaataat gtttttctaa ctaaagaaag tcttttcttt 2972461 agacacttta acataggaaa aatttctcga caagggaaga tgattactga catttttaag 2972521 ccgggttgcc gcaaactatg tgtattcaat atgaaaggag attattttgt gaaagttttg 2972581 ttatccgctc ttcttctcct tttgtttgca tttgagcctt ctgcgtctgg aaaaaaactt 2972641 tcagatccag tgctgtcgaa acggatggaa ttatatcata aaatcgaagc tgtgacgcag 2972701 atcccttggt atgcgctcgc cgctgttgat caatacgaag aaaacgtgcg gagcaaccgg 2972761 aaagatctgc ctgaaaaggc gggaatcatc agcatctata tacccgatga tatctggagc 2972821 gggcctgaaa acccgaatcc gaaagacgat gcgccgttaa gcattaaagt gtttgacgga 2972881 atcggaatgg atggcgatgg agacgggaaa gccgaggtca gcaacgatga agatatcttg 2972941 tatacgttca gccaatactt actgtcgtat ggcacagatg aagacaacat ccggatcggg 2973001 ctttggaatt attaccggcg tgatcagaca gtggggatta tatctgaatt catgaagctg 2973061 tttaaagcct acggccatat tgatctgggc gagcatgcat tcccgcttcc gatcagaacc 2973121 gattacagct accgaagcac gtggggagat gcccgcggct tcggtggaag gcggattcat 2973181 gaaggtacgg atatctttgc ccattacggc cttcctgtca aatccacatg ttacggcgta 2973241 gttgaaatga agggctggaa ccgcttcgga ggatggagaa tcggcatcag ggacattaac 2973301 aatacgtatc attattttgc ccatctcaat gggtttgcca aagggattaa aacaggacaa 2973361 atcgttgagc ctggccaagt gatcggatca gtcggcagct ccggatacgg cccgccggga 2973421 accgccggga agttcccgcc gcatctgcac tatggcatgt acaaagataa cggaagaacc 2973481 gaatggtcat ttgatccata cccgcatttg agggcgtggg agcgatatga ataccaaaaa 2973541 aagaagtaac aaaaagccgc ctcttcaaca ggcggcttat ttgctgcttt tttctttttt 2973601 tgaatcggca ccgttttctt tgctgctcgg aagctggaca gaaggcgtga cacccgagcc 2973661 gccgcttcca ttataaaact gcggcacttc gccctgcact gctttaatcg atacaggaac 2973721 attatttgtg acgacagcgg ttttgctggc aaatggaatg atgaccttca ctttaatttc 2973781 gacaaagatg ctgatatcaa taagtgcgtt atttatgcca tacggcttga ttttggtttt 2973841 gacatctgta aaagcgtcac cgattaaatt gaaccggacc gggattttcg gcccgaggtt 2973901 tccaagaagg ctgttgccgg ttacctgtcc cagcggaatg ttgatcataa tgttttcact 2973961 ggcgccgctg tgtccggtat gggtttccat ctctttcaaa tgagcctgaa gctgctttgt 2974021 cacttttgtt ttcacactgt ttacaacctg tgtattaaaa tcgattgtcg ttaagtttcc 2974081 gttttcatca gaattcattt gaaacatatc tttcatattt tcactgtcag acatatagtc 2974141 ctcaatcgaa tcctggatca cctctgtcgc tatacgcttc gtttccatct cgccgatgtc 2974201 cattaaaaca ggtttgatcg agccattgat catccaaagg ctgaccgttg ttgacaggat 2974261 aaaaaagaca acggacagga gcatcacgta acggaaaggc aaaggtcctc tcttgcgaaa 2974321 agggccgcga tatcttggca agaaaatccc cccttacata tcacaatgta tgcttgtaag 2974381 aggggacata gtaatagccg gggccaattt attttatttc atcattttta aaagcgcttc 2974441 tctgccgctc atgccgactt tgatgccaag atcttccgca gcgtacgtga cggattctaa 2974501 aggtgcgtct aacagctggt caatggtgcg gacaccaact gcgcgtcccg ccacgatgcc 2974561 gcgctccttt aatttttcat tcagcagcgc cacatcaagc gcgccgcaca taatgtatcc 2974621 gtgatcattg gcgacggcca taaaattcgt tttgggaagc tttactgtca cagctgtaaa 2974681 aggctgtcct tctatcatga tcggtgtcag gtttaccacg tcaaccactc ccttcattca 2974741 tcactttatg atgaagggca cagcttgttg tgggctgact gccttattgt gcaagcttcc 2974801 aagcaagcag atcccgcaaa aattccggca taaaatattc tttttctgca gcgtcgcgaa 2974861 tcaacggaaa cagtttgccg agcgtaaaca tatcaagcac cgcaacggag tattgtttat 2974921 gtttttcaat atcttccccg ttcagtgtga tccgagtgac gtgggtgatc ccgtcatcga 2974981 gccgtttcgt ttctacctca acgccggcat acaccatttt ccccatcact tctccgcgga 2975041 agccgagtcc tttgatccgg agctgctcca tttgttcgga agcggcatgg acaatggttt 2975101 ccttcagttc ttctcccgtc aggcggacag ccaccgggtt gatcggatgc ggacagatgc 2975161 ggtgcagatc cagctttgtc acaggacctg cttttagcgg accgagaatg acacctgaat 2975221 tgaccatact gatgtccgtc tcgcaccatt cctttaaggc gtatgccaaa agcaaaggca 2975281 gctctgattc ttcaaaccac ttcacctcag catcttgtgc aagctctgca acggcatcgg 2975341 acagtttctc ctcggcttca cgttcttttt cattgagaaa cgctttagtt tctgcggatt 2975401 ctcctgtcca ttccgccatg ttctgcacag aagccgtttt gctgttgatg cttcgctgta 2975461 cgctgtccac cgtgatttct acacagccga cataatgccc gtatttctcg gcgctggcca 2975521 gcagtacccc attaaccact tgtccatctt cgagcaaatg atgggtatgt gattcgagga 2975581 ttacatcaat ctcaggcacc gcttcagcca ctgcttgatc atcaagaatg cctaaatgtg 2975641 acagcagaac gataatatca gcctgccctt tcacttccag aatggtttcc tttatgcttt 2975701 caagggcatc cgtaactgtc catcccagct tgtcatatac aggataatac ggcacagtta 2975761 cacctaagaa agcaatggac ataccgtttt tcaatgattt gatatggtaa ggcaccgccc 2975821 aggacggacg gtttccattt ttatcaaaca ggttagagac gatgacagga aattcagcat 2975881 gatcatataa ggcagcaagc tcttcatgcg gaagcgtaat cccttcgtta ttgccgatcg 2975941 ccgctccatc aatgtgaagg cggtttaaga gatcgacatt cgcttttccg aatgtcgcct 2976001 ctgtcacgaa ttgaaaacga tcaagatgat cgccaatatc aaaaacgagc gtctcttcgc 2976061 cgtctgactg atgctctttt cttttctgct cgatataatc tacaattttc ggccagtttt 2976121 caaaatggct gtgcaaatca tttgtatgat ataagcggag cttctccttc ataatatctc 2976181 tccctaatcg ttcagctgaa aatgccttca taaatgagct ggcagccgat caaaatcaat 2976241 acgatccgca tgatcataac gatcgttttc gtctgcattt ttctgttgat ggcggcgcca 2976301 agctttccgc cgaaccaagc gccgggcaca agcgcgaggg cgtacagcca attgacgtgc 2976361 ccggaaatca tatgtgaaac agaccctgtc atagaagaca ggaaaataat aaacatggac 2976421 gttgccaccg caaccttcgg cggaaacaga aataacagca tcatcgccgg aaccatcagt 2976481 gatccgccgc ctataccgaa aagtccgcct aaaaaaccga caacaaaggc aatggcaata 2976541 ccgacagagg cctgatatga gtacgtataa ggctcaccgg catcatcctg aaatgtccgg 2976601 ataattcctt tgtgcgcttt gttgattggc cgggctttcg ctttcagcat taaggataat 2976661 gaaatcagaa tcataaaaat gccaaaccaa acggaaaacg agtttgaatt gaacagcttt 2976721 gacacgtaag ccccgatcat gctgccggga cccgaaccga taaagaaaat gagtccgctc 2976781 ttataatcaa ctgttttata tttaatataa gccaaagttg aagaaaggcc cgtaaaaata 2976841 atgaccaaaa gcgaagttcc aatcgcaacc tgcggcgtca catcctgaaa cagctgcgtc 2976901 actgtgctta aaaacatcag agatggcaca atgacaattc cgccgccaag cccgatcaga 2976961 cttcctaccg tacctgcgat taatcccagt acgaccaaaa tcacaaacga catcaatcaa 2977021 aacctctttt ctaaaataaa tcgagctgtc tcggagcaag tccgctgtac tcgatatcaa 2977081 gcagttcaag catctgcttg ccattatccg cagcgtcacc gccggaattg ttgttgaaca 2977141 ggacaaaaac atccttacat tgctgctgca attcattcag gtgctttttc caatcctcca 2977201 gctcctgttg gttgtagcgg tataagtacc tgacctcccg ccagtttttc ccgccatcag 2977261 gcttcatcca gccctgcttg ttgcgtccgt gaaacctgac gagcgttttg ttttcatcgg 2977321 tcgcgcgcaa cacggtcgga acgctgcctt ctccgatttg cggttcatca cagacactgt 2977381 gaatccagcc ttccgctttc ataaatgaaa gcgtctgctc ataaaatggc ggcgagaacc 2977441 aggaacggtt tctgaattca agcgcgcaag gaatatctcc catttggtgc ttacaccatc 2977501 tcaaataggc gacattctcc ttcttgcagt caaaccacgg cggaaattga aacagcacca 2977561 tggcgagctt attgctatgt aaatatggcg ttaaagacac cttaaacgca tcaaacatct 2977621 cctcttttga gtcaaaggga atttcgccgc gctgatgccc tgtcatgccc tgatatgctt 2977681 tcacgataaa ttggaaggtt tcgggcgttt ccttcaccca cttttcatta ttgcgcgccg 2977741 gctgaatcgc gtaaaagctc gcgtctaatt ccacgatcgg aaaatgggag gaataggcct 2977801 gcaatttttt ctggctggcc gttttcggcg gatagatgct gtcatgatcc ccccatcccg 2977861 tcagtccgat ataaatcaca ctcattcacc tctcttccag tttatcacac gtgttttcag 2977921 gtttcctcgg aaatgctgtt catatggcgg gaaaatgcct cacgcaaatg ctgatattgt 2977981 tcctcattcg tatctaaaaa cgcctcttct cttgaggaag gaatgtgctg atattcaata 2978041 ggcgcctgaa actgctcact cgtaaaatcg tacaccacac cattgatgct gttataaaaa 2978101 tgccagctct catcgactct tgttttgaaa atcgtgccgc cgaaatggtc ttgaatcacc 2978161 aatgccgtca cgccgcattg gccgcatgac gggcattctt ccgtccattt agagctcgaa 2978221 tggcgcgacc aggattgctt aagtatgtat ttgacatgct ccattgcctc cgcctccttt 2978281 aaaaaaagat accacgttga tgagatttta aaaactagaa cggaggaaat caaaaaaccc 2978341 ggcggtaaaa tccgccgggc ttacgaagga acgaccagag ctccgtcaat ttcagtgact 2978401 ttttccccat cattgtacac gcaccggcct ttgctgtaag tggccgaaat gctgcaggga 2978461 aatgtatgtc cttcgtaaat gcttttttta tgctttgcaa acatcgattc tcttgtaaca 2978521 gtgtacggct ccatgctgac gagcacgaaa tctgcatcac accccgcctc aagccgccct 2978581 tttttctgaa ggccgaatcg ttttgcaggg gccgccgctg tccattctgc gatggtttca 2978641 aatggaatct gatgctcaag cgccagttcc agcattccta ataaagtgaa ctgcccgccg 2978701 ctgattccgc cccatgataa aaacatgtta tcctcccgct tcaaggatgg acggcaaggg 2978761 gaatggtctg aggaaaccat gtcaatgtcc ccggcaatga gcgtctcgat cagcgtctct 2978821 tttgattgcc gtgaccggag cggaggcgcg cattttgcga cagagcccct ttgccgtaaa 2978881 tcgtcatggc tgaacaagac ataatgcgga catgtttcaa ccgaaacatc aagaccttcc 2978941 tgtttcgcct ctctgatcag ccggaccgct ttcgccgtgc tgatatggac aaaatgaacc 2979001 ggacagcctg tcaccttcgc atactgaatc gtgcgataca ccgcttcaac ttctgcttcc 2979061 tccgggcggg aggcggcgta cgcatccgca tccacctttc ctttattggc caaaaccatc 2979121 tgcaagtagc ttgtgatcgc gtcgctttcc gcgtggagag cgaggatttt tcctgcagcc 2979181 gcgatttctg ccatgccttt gagcaatgtc cgttcatcaa cagagcggaa ctcatcagtg 2979241 cctgactttg ataaaaacgc tttaaacccg atcgctcccg cttcagccat cggacggatg 2979301 tcctcgatat ggcctggcac aaggccgccc catagcgcaa aatccacggc agatttttgc 2979361 ctgcctagct cagcttttgc gagaagatgc tctgccgtca cggttgatgg aatacagttg 2979421 agcggcatat caaaataggt agtgcaaccg cctgcggcca tcatttgaga acctgtttca 2979481 aacccctccc aatcctccct gcccggttca ttaaaatgaa catggcaatc tatcacacca 2979541 ggaaacacgt atttcccgtc tgcctggatg atttccgtcc cgcttgcttc aatgtcagaa 2979601 cctatctcgg caatgacacc gttttgaact acaatatcag cttctataac gccatctggc 2979661 gtaactgcct tcgcaccttt tatcaccata tcgtaagcca tattgatccc cccatgtcag 2979721 gatgacgatt ttccatgtca gtttatgtaa cacaaccagt tctattttca acagtttact 2979781 gctactatga tcgtattaca tcagcaaaac cgctagaatt cctattgaaa attattcacc 2979841 ttaaccaatg tttttataga aaaggagaat gcgctatgaa tattcttgat gtgatgaaaa 2979901 taccggcttt tgaaaacgcc aatttaatcg ctggaaaagc aggaggggaa agagaggttc 2979961 agcatgtcaa tatgatggac gctccggata tcgtagactt tttgcataag aatgaattgc 2980021 tcgtcaccac cgcctatcac ctgaaggatc acccgcatca attatctgaa ctgattcggc 2980081 aaatggcaaa acgcggctgc gcgggcctcg gcattaaaac aaagcgctat ctggaagata 2980141 tcccgaagga aatcatcgaa ctggccgatt catatgcgtt tccgatcatt gagcttccgg 2980201 aacacatccg actcggcgat attgtgaatg ccacactcag ccatattctc gatatgcgtt 2980261 ctaacgagct gcagcaagcc atttacgcgc acaaaaaatt cacaaaccac attatgagcg 2980321 gcaaggggct gcaatccctc ctcaaaaagg tgtcagacat ccttcagctt cccgtgctgc 2980381 tgcttgacca gcatgccaaa atgctgtctg cgtctcatca gatttcagtt gagaccgaaa 2980441 agctgaaagg caccctgaat accgtatccg ggccattttt cacttgtttc tctacaatct 2980501 cagatcagaa aacatattct gtcctgccta tttataatca cgaaaaaaac tgcggctacc 2980561 tgctgatacc cgacatggtg caggcaggcg acaaaggatt gatcctcacg attgaacaag 2980621 cggccaacgt catttccttt gaactgctga aggaaaatgc gctgaagcag ttcagccggc 2980681 gggcccgcaa tgagtttttc aacaatttta ttgagcggac cttttcttca gatgacgaaa 2980741 tcaaaaaccg ggcgaaagaa ttcaagctgc gctgggatca aaaatacatg tgcatcgccg 2980801 gcaaactcga tcgcaatgac gaatcaatca gctttacaga aaatcagctc gcttccgaca 2980861 gcgtattcga atttcttgaa ggtgaattat cagccttccc gtttccacct cacttcttta 2980921 tgaaaggaaa tgtcggcatt attctaatcg aggcgacaga cagctggagt gaaatgcacg 2980981 cctcggtgat cagcttttta gaacagtttc aaacacaggt cagcgctcaa tttaaacgaa 2981041 ccgtgtcctt tggcatcagc aatatctgcc aaaagctcat tgatgttccc gacgctttca 2981101 cagaagcttc tgatgctctg caatcggggc atttgtcaag aagcaccgca tttatccagg 2981161 tgtatcacgc caaagatgtg cctgagcttc tgcgcttgct cccagttgag gatttgaaga 2981221 aattttacaa ctccacgctt cagagcctcg ctgaaaaaca gcaggaggat caaagcctgc 2981281 ttcatacgct ttccgtctat ttagagacac actgccaaat ttcagagacg gcaaagcgtc 2981341 tgtacgttca tcgcaatacg gtcatatacc gccttgaaaa atgcgaagag cttctgggga 2981401 aaagcttaaa agatcctgaa acaacgatgc gtttgcggct tgcattacgt atgcagcggc 2981461 tgatcagcta aagtttgtta cattttctta caaaacgaat cgtttttcgt cactttcagc 2981521 aatcacacct gtctttttca gctactgtat ccaatgacac ccctcgaccg gaacgatatt 2981581 atgttactaa agttcacata cagggaggga ctatagtgaa aaaaagatcg tttaaggtgt 2981641 ttacacttag cctgcagcat gtgctcgcca tgtatgcagg tgcgattttg gtgcccctgc 2981701 ttgtcggcag ggcgctgaat gtaacaactg aacagctgtc ctacctattg gcgattgacc 2981761 tgttaacatg cggcgtcgct acgcttttgc aaaccttgcg cggaacatac atcggcatcg 2981821 ggcttcccgt catgcttggc agttcatttg tggccgtcac cccaatgatt gcaatcggca 2981881 gcaattacgg cattcacgcg atttatggtt ccatcattgc ggccggtgtg ttcatctttt 2981941 tgtttgcgcg ttttttcggc aagctgactg tgttatttcc tcctgtcgta acaggtaccg 2982001 ttgtgacctt gatcggcctt tcacttgttc cgacaggtgt gaaaaatatg gctggcggcg 2982061 aaaaaataaa cggcagcgcc aaccccgaat acggttcgct cgaaaacctt cttctctctg 2982121 tcggtgtcct tgttctgatc ttagtcctca accgctttct caaaggattt gcccgaacac 2982181 tgtccgttct gatcggcatc gccgccggaa cagcggcagc agcgatcatg ggcaaagtca 2982241 gcttttcttc tgttacagaa gcaccgttct tccaaatccc gaagcctttt tacttcggag 2982301 cccctgcgtt tgaaatcggt ccgatcttaa cgatgctgat cgtcggaatc gtcattattg 2982361 tggaatcaac cggcgttttt tacgcaatcg gaaagatatg cggcagacct ttaactgaca 2982421 aagatctcgt caaaggctat cgagcggaag gaatcgccat tctcatcggc gggctgttca 2982481 atgcctttcc ttataatacc tttgcgcaaa acgccggctt attgcagctg accaaagtga 2982541 aaacaagaaa catcgtcgtt accgcaggct gtatccttgt ctgtctcgga ctgattccga 2982601 agattgccgc ccttgcatct gccgttcctg ctgctgtact tggcggcgcg accgtcgtca 2982661 tgttcggcat ggtgattgcc tccggcgtca aaatgctcag cacagcggat ctcaaaaatc 2982721 aataccacct cctgaccatc gcatgctcaa tcgcactcgg catcggcgcc agcacggccc 2982781 ccgggatttt tgctgaattc cccgctccga tccggattct ggtcagtgac ggcaccatca 2982841 ccggaagcct aaccgccatc tttttgaatc tatttttcag cttgcgcgac aaaaaagaat 2982901 taacagcaca gcaaacagaa cttccggtat tagaacatac actcgcatta gaaaaagagg 2982961 tgtaaaaaag atgaaggaac agcacaatgc cttacagcta atgatgctgg ggcttcagca 2983021 catgcttgcc atgtatgcgg gagccattct cgttccgttg atcgtcggag cagcgatcgg 2983081 gctgaatgcg gggcagctga cgtatttaat cgcgattgat ttgtttatgt gcggggcggc 2983141 aactcttttg cagctctgga gaaaccgata tttcggcatc ggccttcccg ttgtgctcgg 2983201 atgcacgttt accgcagtcg gcccgatgat ttccatcgga agcacttacg gtgtcccagc 2983261 gatatatggt gccattatcg ccgcaggact gattgtcgtc ttagccgcgg gcttcttcgg 2983321 gaagcttgtc cgtttttttc cgcctgtcgt aaccggatca gtcgtcatga tcatcggcat 2983381 cagcctgatt ccaacggcaa tgaataacct ggccggaggt gaaggaagca aagaattcgg 2983441 ctcactcgac aacgtgctcc tcgggtttgg cgtcacagct tttatcttat tgctgtttta 2983501 tttctttaaa ggctttatcc gctccatagc gattttactc ggtcttatcg caggaacagc 2983561 ggctgcatat ttcatgggaa aggtcgattt ttctgaggtt ttggaggcgt cttggcttca 2983621 tgttccgtct ctgttttatt tcggaccgcc aacctttgag ctgccggctg ttgtcacgat 2983681 gcttctcgtt gcaattgtca gcctcgttga atcgacaggc gtttattttg ccctcgctga 2983741 tatcacaaac cgcaggctgt cggagaagga tctggaaaaa ggctaccggg cagaaggcct 2983801 tgcgattttg ctgggcggct tatttaacgc gtttccctat acagctttct cgcagaatgt 2983861 cggcatcgtt cagctctcaa agatgaaaag tgtcaacgtc atcgccatca caggaatcat 2983921 actggtcgcg atcgggctgg ttccaaaagc agcggccctg acaacagtga tccccacccc 2983981 agttctcggc ggcgcaatga tcgtcatgtt cggcatggtc atttcttacg ggatcaaaat 2984041 gctatccagc gttgaccttg attcgcaagg caacctgctg attatcgcct cttccgtcag 2984101 cttggggctt ggcgctacaa cagttcccgc gttgttttca tctctttcgg gcgcggcctc 2984161 tgtcttggca ggaagcggaa ttgtgatcgg cagtttgacg gccattgcac tgcacgcttt 2984221 ttttcaaacc aaacagccga atagcgcaga cataaaaacg taaaggaaga tgccaatgtt 2984281 cacaatggat gacctgaacc aaatggacac acaaacactg acagacacac ttggctctat 2984341 ttttgaacac tcttcatgga ttgcggagag atccgcagca ctacggccgt tttcgtccct 2984401 ttctgatctt caccgcaaaa tgactggcat tgtaaaagct gcggatcgcg agacacagct 2984461 tgatttaatc aaaaagcatc cccggctcgg aacaaagaaa acaatgagcg atgactcggt 2984521 acgagagcag cagaacgcag ggctcggcaa attagaacag caggaatacg aggagtttct 2984581 catgctgaat gaacactatt atgatcgctt cggctttcct tttattttag cggtgaaggg 2984641 aaagacgaaa caggacattc accaagccct gctggcaagg cttgagagcg aacgagaaac 2984701 ggagttccag caggccctta tagaaattta ccgaatcgcc cgctttcgtc tggctgacat 2984761 catcactgaa aaaggagaga cgcaaatgaa aagaaccatg tcttatggca aaggaaatgt 2984821 atttgcatac cgaacgtatt taaaaccgct cactggagtg aagcaaatcc cggaatcatc 2984881 ttttgccgga agagataata ccgttgtcgg cgttgatgtg acatgcgaaa ttggcggaga 2984941 agccttcctg ccatcattta cagacggaga caacactctc gtcgtggcaa cggattcaat 2985001 gaaaaacttt atccagcgcc atctcgcatc ctatgaagga acgacaaccg aggggttcct 2985061 acactatgta gctcaccgat ttttagatac ctattctcat atggacacga tcactctgac 2985121 tggcgaagac attccgtttg aagcaatgcc tgcatacgag gagaaagagc tcagcacaag 2985181 ccgcctcgtc ttcagaagat cgcgtaatga acgaagccgc tctgtgctga aagcagaacg 2985241 aagcgggaat accataacga ttacagagca atacagcgaa atcatggatc ttcagctcgt 2985301 caaggtgagc ggcaactcct tcgtcggctt catccgggac gaatatacga ctctcccgga 2985361 agacggcaac cgcccgctgt ttgtctattt aaacatcagc tggcaatatg aaaatacaaa 2985421 tgactcatac gcttctgatc cagcacgcta cgttgcggct gaacaagtcc gcgacttagc 2985481 gagcaccgtt tttcacgagc tcgaaacccc ttcaatccaa aacctaatct atcatatcgg 2985541 ctgcagaata ttagcgaggt tcccgcagct cactgatgtc agcttccaat ctcaaaatca 2985601 cacgtgggat acggttgtcg aagaaatccc gggctcaaaa ggaaaagtct acaccgaacc 2985661 gcgcccgcca tacggtttcc aacattttac cgtgacaaga gaagacgccg agaaagaaaa 2985721 acagaaagcc gctgaaaaat gtcggagcct gaaagcctga tgggaaaact gacaacccat 2985781 attttagatt taacctgcgg caaaccagcg gcgaacgtaa aaattggatt gaagcggctg 2985841 ggcgaaagta ttatgaaaga ggtatacact aacaatgacg gcagggtcga tgtccctctg 2985901 ctggctggtg aagagctgat gtcaggagag tatgtgatgg aatttcatgc aggagactat 2985961 tttgcgagta aaaacatgaa cgcagccgat cagccgtttt taaccatcgt caccgtccgt 2986021 tttcagctag cagatccaga tgcacattat catatcccgc tcttgctgtc gccgtttggt 2986081 tatcaggtgt atagggggag ttaagaagga agcccgcctc accggcgggc ttctttttgc 2986141 acttcaatta acttttgatc ctaggacagt acttgaagtg atccccacac ttagtgaaac 2986201 aacagctaga ataaacattc acctatattt ttcaggataa ttgcctacga gaaaaatacc 2986261 ctgtagtcct ttcatttata aatcgaggtt tcaaactaat aagtcagctc ttagcagccg 2986321 agctcccttc tccaatccta taaacagacc gcgttttttc tcgaaaaaat actctgaaga 2986381 caattgctgc gtttttaata gttttgataa cgcgttctct cttacacctt tagacaaaat 2986441 attcattttt tcttttttag acttaaatct atgtcgaaaa taatcgttgg catatcttat 2986501 cctatctcca ctaaaggagg tgacattatg ggattctaca attctggtgg atacagtgga 2986561 aactctggtt actcaaacgg tttcgggagc tccttcgctt tgatcgtggt gctattcatt 2986621 ttgttgatca ttgttggagc agctatcttt aattattaag tttaactttc cttgcctccg 2986681 ccgtatccaa cacctccctg tccgacagac gccataagaa gtttttatgg cgtctttgct 2986741 atgtgttcac taatcttttt gtaatccaga agctgtcaag ttctacgaga tttatcgtgt 2986801 gttttcccac aacgcttctg cgtcttgatc gcgctgtctg actgaggcta aaaaagtccg 2986861 gcttttaaaa gccggactcc cgtctacccc cgttcaactc tcttctaatc ctgcaagctg 2986921 accgcataat cccgccatac ccggtacacc ggcacaaatt ccccgccagc ccttcttcta 2986981 tatctttgtc agaaggttga ggggtttccc gaaacaatgc tttaagcgca atgatcattc 2987041 ccggcgtaca gtagccgcat tggaagccgc cttcttccag gaaagcggtt tgacacatat 2987101 ccagctcttc tttttgaagc ccctcgatgg ttgtgatgga atggccgtct gcttgatagg 2987161 ccatcgtcat gcacgcattg gccagttttc cgtcgattaa aatagagcag gctccgcagc 2987221 ggccgattcc gcaggacacc tttgtcccgg tcagctgaaa ttcctttcta agcaggtcac 2987281 tcagatgtgt cgtaggaacg gcagcaacct cccacgcctg accattcacg gtcatccgga 2987341 actgttcctt ttttacagga aatggcccgg cctcttttat gtccattgct tcagcccctt 2987401 tctgtcgatc gcttcaagca actcttctct tgaaattggc agcttgttta tccagcatcc 2987461 gaccgcatca tgtactgcct ttacaatcgc cggagtgatg gcgattgttc cgatttcacc 2987521 aacaccgcgc ggtccatata cgtctccctt cattaagtct tctattgcaa tcagcttcat 2987581 gtcaggaaca tctttgattc cgggaatcaa atagtgatcg agattttccg cagcataacg 2987641 gccatccgtc attttcgctt cctccatcag tgtgtagccg agtgccatgg cagcgccgcc 2987701 ttcaatttga cctcgatatc cctgcggact gacaaccgga cctgccgcaa tagcgtgctc 2987761 acaatctatc aatttgacat cgcctgttaa cagatctacc tccacctcaa cggcagccgc 2987821 tccaaatgag tagaggaaat ggccgcccac cacaggatca ggcgttgttg gaaagtcaaa 2987881 ggccgtttcc tctgccaaag ggcctttttc agccagctcc ttatacgtca ccacgagcgc 2987941 ctttgtgttt ttgtcacgca agcctgcagc gccgggaata agattttccg ctgaacagcc 2988001 gctccattct gccgcccgtt ttttcaactg agctagaaac ggcttcttca aacgctggat 2988061 cgcgtgccac accatgcttg tgccgcggga tgctgtggag gagcctgact tcggcacttt 2988121 tgcggtatcc ccaataacaa tggaaatatc ctctgcggca caacccagct cctccatgac 2988181 aatctgttca atcgctgcta gaatcccctg tccgcattct tcaaatccaa acgaagcagt 2988241 gattttgcct tcactcgaaa gagacaaacg gcctcctgcc gcatccattc ggccaaaccc 2988301 cagcccgccg ccgtgcattg taattgccgc tcccgtgcct ctttgcagat acccgcagtt 2988361 ccggcttgtt tttttaagaa tgggagattt agatatggca ttcaacacct gtgccgctcc 2988421 gtcagttggt gcaattcgat gctcaagcgg ccccaagtca tgcggttttc tgatattttt 2988481 tcttctcagc tcgagcgggt cgatgccaag catgccgctg agacgatcga gatgggtttc 2988541 gagtgcaaat gtgatttggt tgccgccaaa gccccgaaat tcccccgcca ccccgttgtt 2988601 cgtaaatact gatattcctt cagtccggat attcggaata cggtacggcc ccgcggcatg 2988661 ctcgacagaa aaatcaagaa cagccggtcc gagcgtagcg taagcgcctg tgtccgccac 2988721 aattttcacg tcgtgcgcca atagatttcc cgaatgatct gcacccgttt ttatcgtaat 2988781 cttcatcgga tggcgcttaa tgccagaacg tacagattcc tttcgtgtct gatgaatttt 2988841 gacagggcgt ccgcttttca gggccaaaag cgcagcatac ggctgaatat tcagctcatc 2988901 cttccctccg aacgagccgc ccatcggact tgacacaatt ctgatcttct cttcaggaat 2988961 atcaaaaata cgggcaagct ggaaacggtc tttatagccg tgctgggttc ctgcatacat 2989021 cgtaaaaccc ccgtcgtctt ccggaacggc tacacctccc tccgtttcca tatacgtatg 2989081 catctgccgc ggcagctcat aggtttcttc aaagactgtg tcagatgctt gaaacccttc 2989141 ttccacatca ccgtttgaaa aaaatgcgcg gtgcaggata ttcccgtcct catgcagtct 2989201 ttgcgcattc ggccgaagcg ctttttctgg tgaatccatg acttccagct ctttatactc 2989261 aacttgaatc agctccagcg ccgcttccgc gatttcttcc gtttccgcag caactgcggc 2989321 gatcgcatcc ccgacatacc gcaccctgtc ctcacataaa accggctgat cagggatgac 2989381 aatgccaaat cggtttaagc cgggaacgtc tttatgtgtg acgacggcct gcacgccttc 2989441 cattttctca gcttttatgg tgcaaaccga cacaatctct gcatgaggat aagcacttct 2989501 cagcaccttg ccatacagca ttcctggaaa gctgagatcg gtcatatatt tcaattcccc 2989561 tgtgacctta ccccttccat ccggcctgac tcttgacggt ttgttgatga tcatttattc 2989621 ccctccctca gccatcagct ctgccatgat gacgttggca gcggcttttt ttctgtatgc 2989681 cgctgacata aaaacatctg aggaaaacgg cagctcatgg ataagtgttt tgtacagctc 2989741 atgcgggtcc caccctggtg ccatccattt cgcttcgctg tccaataatc tcctaggagt 2989801 gatatcggca tggccagcgg cgaggcgaat gctgccgtct ttcaaaaaac gtccagctgc 2989861 aacagcagcc gctccggtaa aagcctggcg ccttccaagc ttgtgataaa atacacgctc 2989921 tccctccgcc cgcgggatga tgacacgcgt gacgatagcc gttctaaagt cttcctcact 2989981 gagccaagcg ccaagcggca gcctgattag ctccttttga tatacgataa gctcagcacc 2990041 aagcacaagc agaagcggaa tgaaatcacc gattttactc gctatgttgc cgccaatcgt 2990101 ggcacggctg cgaatccccg gtgcagcgac agcggaagca gcgtcactga aacagctaag 2990161 cgctctctta atcaaagggt tctttctgca ttcattcagt gatgtgagcc ccccgatcga 2990221 cacgtgggtg tcactggtgc tgatccctcg catttcgtca atcccttcaa ggctgacaag 2990281 gtgctgtttc ggtagagttc ctttgtccca ctgaagctga aggagcgtgc ttcccgatgc 2990341 ggcacacaca tccggagcaa gcttctctaa aagcgaatag gcctcatcaa gcgctgccgg 2990401 tctccataat tgaatattca tccttgcttt tgtcacttgg ccgttcaaga catcgccctc 2990461 cttaccatgt catattcctc gggtgtatca atatcgtcca actcaccgct atcctttgcc 2990521 tccaaaaccg ctcctgctcc aagctgtccg cttttcagga gcctgcgagc cccttcatct 2990581 ccctttaatc cctttacata aggaaaacat gtcgacgaga agtagattgg cggggtgaac 2990641 gcccctaaaa acgatgacac ggcaaatgac tcaggagcca gagccacaag ggcattgaga 2990701 tgatcgacgg aaagctgagg ctggtcggct aacaaaatga caatgccgtc cgcccccatg 2990761 ctttctgctt ttctcacccc gctgctgact gaatgcccct gacccttttc tgcgtcttgg 2990821 caaacgtgca ggctccagcg tttttgaaaa ggcggagcgt gatacggcgc tcctatccac 2990881 tcaagggagg catgttctgt ccgctcgacg accagcacgt gatcaaggcg ggacgacaga 2990941 gcagttttca aggaaagtga gcctatgttt tctcctttta gcggcaaagc cagcttgttt 2991001 tgtcccattc ttctgctttt gccggcagcg agaaacacgc cgatcagata ggggcttctc 2991061 atacaaccgc cacccgtttt cttgtttgaa tgatttctgc aactacactt accgcaattt 2991121 cctcgggacc ttccgcaccg attttcagcc cgaccggact gtaaaagtga gacggaggat 2991181 gttttccgct cagcagccgt ttcgtgcggt ttgccgaacc caacagtcca atataatgga 2991241 ggttttgaga aaataagaag ttgatgatcg tttgatcgtg ctgataatga tgggttgcca 2991301 caacagctgc atcatgcgga aaaaattgaa attcgctaag catttgttcc ggaaaagcgg 2991361 tgatcagctg atccgctttt ggaaaaagag aggatgtaca ataagcgggc cgccaatccg 2991421 tcacgataac agaaaaccct gtgtcagccg ccaaattggc cagcggtaca ttatccggtc 2991481 ccgccccaaa cagaatgaga cgcggcttcg gttcaattcg ctgaataaac atgttagtgg 2991541 tttgatcgaa atgcggtaaa tgaagcgttg aaacagtacg ttgaatatct tgcagaggcg 2991601 cgtccggcca gttcccaaaa tgtccgttct ccgtcagaaa taaataatgg gaggattcaa 2991661 tctttataac ggaagtgaca gctttgcctg aatgaaggca gtccctcact ttctcatagt 2991721 gccgcctttt ttcctgagtg attcgctctg catgaacatg aataatgcca ttgcacccgg 2991781 ctcccatgcc ccaagaaaga tcgtcctccg accgcatgtc gtagggaatc agcgttgatg 2991841 tgagctgatc gcccagcgca ctgattcttt ggaatacatc ttcttccaca cacccgccgc 2991901 tcagcaagcc aatccgtctg ccttttttct taaagagcat agaggcgcct gcttttcgat 2991961 acgcggagcc ttcaacttga acaattgtcg ccagtacagc ctcctcctgg tcttccagga 2992021 gcgcatctaa catcgtgtga aaattcccca atgccgcatc ctcctctcga aaattgccgt 2992081 gagaaacaac tagttcagcg tgattttata ggtaacttgt ataaagaata gacgatggaa 2992141 gaaaaaatga ctcatgattt gtcagaaaat gaaacacata gaaagaggat ttgtaaaaag 2992201 agtcaaacga agaaaatcag attggagaaa acacgaaatc atatcgttaa aaagcttgcg 2992261 gagttccgca agcttttctt tacaccgctg cctggcggcc agcgttttca tacacatcca 2992321 gcgctgcttg gagcgctttt cctgcttcga ttcctgcgtt atgtctgaga agcacagcct 2992381 ctaacccggc aagcacgaat agcacgtttt cttttctgca gctgtacccc atcgtgccga 2992441 tcctccagat cttccctgca agcgggccga atgagctggc gatttcaatg ccgaattgtg 2992501 ccagcagcat gtcacggaca gactcgccgt caatgccgcc gggaatttcg acacaggtga 2992561 caacaggcat tttgcagctg tcatctccaa acaatcttag ccccattgcc tttatccctg 2992621 ctgctaatgc ggcttcatgg tgccgatgcc gctcgaaacg cgtctcaaga ccttcttcaa 2992681 gcaccagtct gactccctca cgtaaggcgt acagcatcgt cgtcgcttct gtatgatgat 2992741 tgagccgtct ttcgctccaa taatcctcaa gctggctcaa atcaaagtag ttgcttgtaa 2992801 ttggccgatt tcccgaaagt gctgccctgt cagcttgtgt cgcaatcccg cgttccacct 2992861 ttttgcgagc tgcaatcacg tccgccaccc gctcattata tgtaatcggc gccattcctg 2992921 aaggcacaga caaacatttt tgcgttccgc cgatggcagc gtcaatcttc cattcatcga 2992981 ctttaacctc gcagccccca atcgttgcga ctgcatcgac gataaacaat gcatcctcgg 2993041 tgcggcaggc ttcgccgatg gctttcagcg ggtgaatccg tcctgtcgat gtttctccat 2993101 gcaccatggc cacaattttc ggcttcactt tttttatctc ccgtatgatg tcctccgggt 2993161 caaaaaccgt tccccattcg cactccagca tatgaacatt tgccccatat cgctcggcga 2993221 tttcagtcag caaataaccg aaacggccgt aaatgggaat gagcacatca tcttccggct 2993281 ctatcacact agccagcact gcttcaattc ccgcccgtga agtgccgtca atcgggtatg 2993341 cccagcggtt ttttgtttgg aacagctccc gaagcatctc catcgtttca ttcataatac 2993401 ctgtaaacgc cggatcaaat tggccgacaa ccggggtgct cattactctt aatacacgcg 2993461 gatcaacctc aacaggcccc ggtgtcataa tcgttcttaa cggggtgcat aattctcttc 2993521 tgcctgacac agccattcct cctttatcag taagccagtt tgtataataa atcagtcagt 2993581 gcgcggacgc cgatctcaag ctgtctggct gacgtatatt ccttcggtga gtggctgacg 2993641 ccgcctcggc tcggcacaaa cagcatacaa gcaggatagc gccttccgat catttgcgcg 2993701 tcatgccctg ctccgctcac catttcctca cagctgaagc cgttttctaa tgctgtttca 2993761 aaagccgcag ccttcagcct ttcgtccatc ggcacaggct ctatccgcat atattcatca 2993821 atcacagcgc gaattccttt ttgtaggcaa atgccgttga tcaaagcaac catgtcttga 2993881 tgaaactgtt ccagcacatg ctgatgctga tggcgaatat cgattgaaaa ctggacgcgg 2993941 cccggtatga cattggctac attgggctct gccgttattt ttccgcatgt cagacggagc 2994001 tcatccggca gctcatccga ccgcagcagc agctcatgaa tgatacggct gctggctgcg 2994061 agcgggtcct tgcgccattt catggaggtg gttcctgcgt gattgcattc tccttcgagc 2994121 gtgacgagat atcgtctctg ccccgcaata cttgtcacga tgccgagatc ccggcctgac 2994181 atttccaacg tcttcccctg ttcaatatgc agctcaacaa acgcgctgat atctgtccta 2994241 tatgctgact gaaacacacc tttgccaaaa ccgctctcat gcatcgctgt ttggagggag 2994301 actcccgact cgtctcttgg ctcttttgca tcttgttctg aaaaaacacc cgtcatattc 2994361 cccgaccccc aataggtcat tggaaaacgg ctgccttcct cctcacataa ggagaccgcc 2994421 tcgagcgttt tttttggcgc tccgtatgtt tccttgagct gctttaacgc gagcattgcc 2994481 gccagaacgc cataggcgcc gtcgtatttt cctccattga tgacagtatc gatatgtgaa 2994541 ccggttacaa tgacttcatc cggagactgg gtgcccgaaa gccttccaaa cacattgccg 2994601 acatcgtcga atcttgtttc aagcccgaaa gaagacattt ccgttttcac agcaagctgt 2994661 gcgtccatcc actcttttgt gtataaaagc ctcgttacgc cgccatccgc agacgcaccg 2994721 tattgggcga gccattcaat ataatctgtg atgctgtttt ttactgaaag cttctgcttt 2994781 tccatgtact cccccctctg gccgctatgg tgacttcatt atagaaggag caacatgata 2994841 gttcattgac agattaacca aaaaaacgtt tattttttag ccacagtatc catccagcaa 2994901 ccagatacac cctacatgtc acaactattt tgatgtaaag gtcaaaagaa aacacggtaa 2994961 ggaagagagc cagcaagagc gaaagagagg gtcaaaatgc ctttcatatg aacaagctaa 2995021 gctggagagg cgatgttcgc ggaacggatg aaaacagaaa tgccggcagc ccgcaaaaac 2995081 aggacctaaa gatatggaaa caggagattt ccgcctcctc caaagggact aatttacaat 2995141 tttaatgaaa aatatacaaa atgacacttc tatcctttat ttcaatttta gataatagat 2995201 atgatctgat aaaaggaggg caagtgatga caaaaaaagc atggtttctg ccgctcgtct 2995261 gtgtattact gatttccgga tggcttgcgc cagcagcttc agcaagcgcg caaaccacat 2995321 taagccttaa tgaccgattg gcgtcttccc cttcaggaac gggaagcctt ctctcattag 2995381 ccgcccccgc tgcaccctat gctgacacag atacctatta tgaaggggct gaaggtaaaa 2995441 caggagactc gctaaaaagc accctgcacc gtattatcag cggacacacg atgctgtcct 2995501 acagcgaagt gtggaacgcg ctgaaagaaa cggatgaaga cccaagaaat ccgaataacg 2995561 tcatcctgct ctatacgaat gaatcgcgtt ccaaaaacct gaacggcggc aatgtcggcg 2995621 attggaaccg cgagcatgtc tgggcgaaat cccatggcga ttttggtacg agcaagggac 2995681 ctggtactga tattcatcat ttgcgcccgg ctgatgttca agttaacagc gccagaggaa 2995741 atatggattt tgacaatggc ggcactgaat atgcgaaggc acccggaaat tattatgacg 2995801 gcgattcatg ggagccccgc gatgatgtga aaggcgatgt tgcccgcatg ctgttttaca 2995861 tggctgtccg ttacgagggt gatgacggct atcctgatct tgagcttaat gataagacag 2995921 gcaacggctc agctccttat catggcaaac aatctgtcct gctcgaatgg aataagcagg 2995981 atccggttga cgaccgcgag cggaaaagaa atgaaatcat ttatgaaaaa tatcagcaca 2996041 accgcaatcc atttatcgac caccctgaat gggcggatga gatttggccg taagaaaaag 2996101 gtgctccttt tgaggagcac ctttttctaa tacacagcct cttccgtttc cgcatcgaaa 2996161 aagacgacgt ggtccatttt cactgagagc tggattgaat cgcctgcatc gattcgcgtg 2996221 tttccgtcca ggcggacctt gagccgctcg tccccagcca tgacatgcac tatgagctcc 2996281 gagcccagat tttcattcac ttccacgttc gcttgaaaca ctgaatcaaa caactggtca 2996341 tttcctgtca tttgtgtgat gtgctccggc cgtacaccgg caatcatctg ttctccggca 2996401 tatccctttt ccttcagccg ctttgctttt tcttcaggaa tatgaagccg gatcgaagaa 2996461 tttgtgaaaa acagctcgcc atgctgctgt tctatgatgc ctttcaaaaa gttcattccg 2996521 ggagagccaa tgaagcctgc gacaaacaaa ttggccgggt aatgataaat gtcatgaggt 2996581 ttcgccactt gctgaatttc cccttcattc atgacgacaa tccgatctcc cattgtcatt 2996641 gcttcggtct ggtcatgcgt gacataaatg atcgttgcct ctaatcgctg gtgcagcttg 2996701 ctgatttctg tccgcatcgt cactcttagt tttgcatcca gattagaaag cggctcgtcc 2996761 attaaaaaga ccttcggctc cctcacaatc gacctgccaa gcgccaccct ttgccgctgc 2996821 ccgccggaga gcgccttcgg ttttctcttc agcaaatgtt caatttctaa aattctggct 2996881 gccgcatgaa cccgctcggc aatttcctgt ttcgccatct ttctgagctt taatccaaac 2996941 gccatattat caaaaaccgt catatgcgga taaagcgcat agttctggaa taccatcgca 2997001 atatcacgtt ctttcggcgg aagatcattg acccgctccc catcaataag aagatttcct 2997061 tcagaaatgc tttctaatcc agccaccatc cgcagcgttg ttgattttcc gcatcctgac 2997121 ggccccacca gcaccaaaag ctccttatcc tttacatcta aatcaaagtc cttcacggtt 2997181 aattgtgagt gatatgattt tttgacgtgt tcaaatgtta atgaagccat cagaaaagtc 2997241 cccctatctt ttgacccgtt atttcgtcac tggaaacaac ttggtctttc tgttattttt 2997301 agagtaatcg attcccattt ttgctatatt tctaaaataa aaaatgtaaa tttgtattat 2997361 aacgtcataa tacattataa tataaataat aggttaaaag gaggctaccc tttgttaaac 2997421 aacggaagtt ctacaccttt atacattcag ctaaaacaaa tcatcactga tgacatcaaa 2997481 aagggcgtgt attccccaac cgccaagctg cctaccgaaa acgagctttg caccaagtat 2997541 aacgtcagcc gcatcaccgt caggaaagcc attctcgatt tagtcgaaga aggctatctg 2997601 atcaggcagc agggaaaggg aacgttcgtt aaaagcccta aattaaaacg agagctgatc 2997661 gctgtaaacg gctactcgga atttatggaa tcaaccggca aaaaaccgaa gcatcatgtg 2997721 ctgtcccatg acatcattcc agcgtcaaaa cccatcgccg aaaagcttca aatccaaccc 2997781 gagagccctg tggttgaatt aaaacggatt ttatataatg atgatcagcc tctcaccttt 2997841 gaagtgacgc attatccgct tgatttgttt cccggcattg atacctttat tgctgacggc 2997901 gtctccatgc atgatatttt gaaacagcaa tacaaagttg tacccacgca caatacgaag 2997961 ctattaaacg ttgtatatgc ccaacaggag gaaagcaaat acctggattg tgatatcggg 2998021 gatgcgctgt ttgaaattga taaaacggct tttacatcaa acgaccagcc aatctattgc 2998081 tcattgtttt tgatgcacac aaaccgtgtc acttttacca tcaacagccc ctacacataa 2998141 caggcataaa aaacgagaca ctgcttatag tattctcgtt ttttcactgc ttcccccgtc 2998201 ctccaagcga taaggatagc catagccgaa agctccgtac acaccgcaag ttttcgcagc 2998261 cgtttcagca gcctggcgca aagcatacgt tatatcctgc ttcacgcaaa aggcagtcaa 2998321 aaagcctgct ataaaagaat ctcccgctcc aagtgtatct attatatcag cttccacaat 2998381 cggctgatga tagactcgat cacccgcaga caggattgct ccttggcccc ctcgggtcat 2998441 acaaaccatt ttggctccgt acccatgagc tgttttggca agctcaccgc attccgactc 2998501 actcaaatcg cttcctgaaa aaaacgcata cgtcacataa ggacagaccc tcctcaaata 2998561 atcatcctcc cgattggttg aaaaatcaaa tgagaccggg accagcccgc acagctgcgg 2998621 aagatcgttc tcaagcctgc tgtacacgct cgtatgcagc agatcatgcc cgctgataaa 2998681 agatacatct ttctcctgaa acgcgaggcg aagccgggac tgaatgccgc ctttatttga 2998741 tctgacaaaa atgcggtccc cctgttcatc aagggtgaca atcgccatcc cgttttctcc 2998801 gtgcgcctgg cggatataat ctgcattgac ctgctccagc ttgagaacgt tcaacagatg 2998861 cgccgcggct tcgtcattgc cgacgattcc gatataggaa gactcatgcc cgagccgctt 2998921 ggcaagcaca gcaacgttta aggcatttcc tcccgggtaa aatgtttctt gatcctggta 2998981 gtaatctaca acattatctc caaccgcaat caatttcata gcgcttcctc ctttatcctt 2999041 ttacactgcc gcttgcaatc ccgcggacaa aatatttctg catcaataaa aatagaataa 2999101 taatcggcgc ggctgaaatc gttaaccccg ccagcaggac gccccagtct gtctgcagcg 2999161 cgtctctgaa ctgcatcagc ccggctggaa tggtccgtaa attctcatca tctatgaaaa 2999221 taatcgcaaa cataaactca ttccatgtat ggtaagccgt caaaatgccg gatgtcacca 2999281 aaatcggcac gctcattggt aagaaaattc tgaaaaatac tccaaaactt gtacacccat 2999341 ccaaataggc cgcctcctcc aattcttttg aaatagaaag aaaataagag cggatcaaaa 2999401 tgatggtgaa tgggatccga taagccgcat acggcaagat taacgcccaa tacgtattgt 2999461 acaggcccag cgactgaata atagaataaa gcggcacaag actgacctgc ggcgtcagca 2999521 tcaatccgcc aagacatagc accaaaaaga atccttttcc tttaaactca aaccgggaaa 2999581 ggccatacgc tgcccatgca ctgataaaga cagtgatcac acacgtcagc gccgtaacga 2999641 tgacactgtt cataaaataa gaagaaatcc cctgattcca ggcggaaaca aaattttccg 2999701 gatgccacga agacggcagc gaccagctgt gctcaaaaat atcgtcagag tttttaaagg 2999761 cgctcatcac catccagaga agcggatagg caatcgcaat cagataaaga aacagaaaaa 2999821 cccacacaga cgtttctccg atataccatt ttcgtctagg cttatctttc acctcaatgt 2999881 gctggtcagg caccggctcc aatctgaacg aatctgtctt cttctgaggc agcatcagtt 2999941 actcctcctt tccggtttta aagaacttca tttgcatgag cgataatgca agcgtaatga 3000001 ttaacacgac agtggcaatc gctgaggcgt agcccatcat atcctttgta aaggcgcttt 3000061 tatataaaaa cgtgctcaag acttctgacg cttttcccgg cccgccgcct gtcaaaatgt 3000121 acggctcatt aaagaccgta aaggctccgg tcagcgtcat gaccaccgca acaaaagaca 3000181 tctctttcgt ctggggaaca gtaatatgaa aaaactgctg aattttaccc gcgccgtcaa 3000241 gccgggccgc ttcatacagt tcatccggta ttttttgaat cgacacgatg tacagcatcg 3000301 caatataacc gacagattgc cactgggaca caaaaatgac agaaagcata gctgtgctgt 3000361 catccccgag ccaggccctc gtcagctgat caagaccgat ggcctgaagc agctgattca 3000421 aaagccctgt ctccggattg taaataaaat caaacaaaag cgcgatcacc gtcattgaga 3000481 tgacaaccgg caaaaagaaa acggtacgaa aaaacggcga ccattttctg accagcttat 3000541 cctcaagcac cgccgccaaa atcaaaccgc caaatacctg gcatacaatt gagatcactg 3000601 cataaagcac attattggta agtgcctgat agaagacagg atcatgaaat aattcaacat 3000661 agttttttaa gccgataaac gttttttccg gagaaaatga gctccactga aacaggctga 3000721 ggaatacatt ctcaaaaatc gggatataaa cgaaaagtaa aaaaacgaga gcgggcacca 3000781 aaaacaaata ggggattatt ttattctgat tgaccaaggg tatctcatct cctttataaa 3000841 aagaaaaggt gcgaagcttc accttttctt tgatttattc agctgacgcc ctcacctgct 3000901 ttgctgcctt ttgaacggct ttcatcacct gctgcggtgt catgtcgccg ccaagcattt 3000961 gctggacgcc cgttaggtac gcatctgcga cttcaacatc gacatccata tcaaaccatg 3001021 gaaccattga tttggcatca acaatatgct gaacggcttc acgctgaatg gctgttgcat 3001081 tttcttcagt agccgtacct tgcactgcac tgtatttccc gacatctttc acgagctttt 3001141 cgcccattct tttcgacgtc aagaactgca aaaattccat cgcttccttc ggatgttttg 3001201 ttcttgagga gatcatgaat ccttccggcg ctcccgttaa cgcttctgaa gatcctttct 3001261 gcccgctgat ttcaggaaat gggaacatcc cgagattaac cggttcaacc agcttgattt 3001321 ccgctgtttc cgcatatatc atcgccgact ttccgctctt aaattgctgt ctcacatatt 3001381 cgtggtcgac ggagtttaca tgtttattaa agtaaggcat cagctcttga agcttttcaa 3001441 gtgcttttac gtagccttca tcagtaaatt cacccgtttt ggcgttatag tccttttccc 3001501 gtgttttttc atcgaccatc cgctgattaa gcgtgccgat atagtgcgag attgtccaag 3001561 tcgcctttgt tccaaagctg atcggtgtgt agccatgttc tttcagcttt tttgacacat 3001621 cgattaattc atcccacgtc ttcgggggat caagattcag cttttggaaa atgtctttat 3001681 tatagaagaa tgatttagcg tccatttgcc acggtacgcc atattgcttg ttttcataag 3001741 taaatggtgt aatttgcgat tgaacgagct gtgatgacca atcggtgtca tttttgtagt 3001801 aggacgagag atcaagtgct ttattgcctc tgataaattt aaaagcaaac tcatcgctcc 3001861 aagagaagta aatgtcagga gggctggtgg ttcccagcat gaccttaatt ttatctttat 3001921 aggagtcatt taaaacggct tcaatttgaa tgtcgatatc tgggtgatct ttttcaaatt 3001981 ccttaacaac ctcttcaaaa taactttttt ccggctcctt tggccatctg tggaaaaatt 3002041 tcaatgtcac ctttccgtcc gctgaactgc tttggctcga acagcctgcg atggtgagca 3002101 tactgacagc tgcaatgatc aagaacaaca acattttctt caaagggttg gcctcctctg 3002161 gacattagac tataatgtta tataacatta tagtctaatg cataatggtt cttcattttc 3002221 agatcaatac tcaactttcc acatgtatct tctatgagat aaaggatgat ttctctcctc 3002281 tgccagctcg tctgcatagc ttctcagcac acgattgaga acgagcggag caagatagcc 3002341 tttaactgaa tcgtcaattg cagtgaagtc gtaagatgca gcatcaagca cagtgagctt 3002401 tttgccatac tttttcgaga aggtaagcgc ccgctcttca agaggtcttg tttcatctaa 3002461 accgagcagg atgataaacg gcacggattc atcaataatt tcaaacggtc cgtgaaaata 3002521 ttctccggca tgaatggcgt gggaatgaat ccattgcatt tccatgagaa tgcagatgct 3002581 gtaggagtaa gcgacaccgt agtttgcacc gcttgccatg gtataaataa tgctttcttt 3002641 ttcatgggct tttgcaaatt gcttggcgtt gtcagcttcc tgcttaaggg ctttttcata 3002701 tacagcctgc aattgatcta agccttcaat tgcttgctca aatttcgtat tgttttctaa 3002761 tacttgcagg gttccaaaaa cgatttgata caaaacgcca tagtttgtat tgatcgcaag 3002821 cgcctcatca ccccaatcgt actgggcaac atattgcgct tcctgcgcta aaggagactc 3002881 cggtttaaac gtcatcgcaa tcgtaagtgc gcccttgccc cttgcaaacg cagcagcttt 3002941 gactgtctcc ggggtatttc ccgaatgcga gcacaaaata acaagagact tttcaccaag 3003001 ctgaacaggg ttgcgctgaa taaattcgtt ggcgctgtag agatcggagt ttattgattt 3003061 tgactctctg tcaaacacat acttactcgg atacataatg gcagaagacc ctccgcatgc 3003121 gacaaagaat acatgatcaa tggttttccc tttcaaatcc tgcaagaaag cttgaacctc 3003181 acgatttact tttgctgtgg cctgactcaa atccttcact cctcgttttt attatataac 3003241 gttatataac attatatatt gttatattaa agtccgcggg taggattgtc aatattattt 3003301 tctgaaattt ctcaataatt tattcggatg acagacaaag ggtctatatg cgaaaaaatg 3003361 cccaaatcaa aagccagaac ttgacttaag ctctggcttc gctgttcaat ccgcagactg 3003421 acgtcttatt taaaaaatac cttgtctata ttgtacttcg agtgctgtgt attgatgata 3003481 tatgtttcgt aaatctctct ttccattgga tcatcaacta cacatacctc aattttataa 3003541 acttcatctc tgtgatgttt gatcggtgaa acagtgtctt cgaaatgctt cttaattctc 3003601 tgtcttaact ttctggcttt accgacaaac agcagctcgt catgaatgtt gtaaaacata 3003661 aaaatgccgc ctttgtccct tgggatctgg tgaaagtcga tgaatccgtg aatcggtttt 3003721 atcttcggct cgttatcatt agctgactgc tgtcgttcag tgatggtgac attcggtgcg 3003781 ggtatatcaa tttttatcaa aatcagttca cgtcctcttt ttcattaaag ataaatgcta 3003841 acacatacag aaaagaaaag ctagaacagc tttattatat ttgtttgtca tgctcttact 3003901 tattatgcaa gtgctccggc tggatcataa ggactaaggt ctaattctgt ctgctttccg 3003961 agaactagct ttgcgagctc tgcacccaaa aacggcccca tcgtcagtcc agaagcaccc 3004021 aaaccgtttg cagcgtacag gccttgaaca ttcggcacgg cccctacgac cggcagaaat 3004081 cccggtgtaa acggcctgaa gcccactctt gtttcaacag cagccgcatc agcaagaccc 3004141 ggtgcaacgg ctaacgcttt gctcaatact tcgtgctggc ctccggctgt cacacgaaga 3004201 tcatcaagac cggcatcgtt ttcgtgtgtg gcgccggcta caattctgcc gttatcaaac 3004261 gacagaatgt actgatcact cggcggcatt acaaccggcc acgatcctgt atctgcatct 3004321 gtcatttcaa aatgcataat ctgcgctttt tgaaatgaca cttgaaaatg aatgccaaga 3004381 ggcttcaata tctcattggc ccatgctccc gccgtcacaa tgaccgcgtc agccgcaaac 3004441 tgctttgtat ctgtttgcac gccggtgact gttccgtttt caaaaagcaa ggacgcattt 3004501 cctttgatga ccgttgcgcc gcgtttctct gcagcgctta aaagcgaccg gcacagcgct 3004561 cttccgttca cacgggcggc accgctgata tgaaccgatt catagccgtc agctaaaatc 3004621 ggaaacagct ttttcgtttc acttgcagac aagcgggtaa tgtcgccgat ttccggcgca 3004681 tcctcccgtc tcttatacgc cctttcctcc attttatcga gtttagacgc gtcagtatga 3004741 atgctgatgg caccgacacg tttgtatcct gtatccgatt caccgtcttt ttccaattga 3004801 tggattaaat ccttatagta ccgcgctccc cccttagcaa gctggtacca atcctgatta 3004861 cggcgctgcg agagccaagg acagacgatc cccgccgccg catcagtcgc ttgtcccggc 3004921 tctttccgat caatgacagt aacgcgagcg cctgtttttg cgagatgata agccgtcgac 3004981 gcgcccagaa tccctgcgcc gacgatgatg tacgatttca tatgcaaaca ccttttctat 3005041 tataatgtct attcatttta ccaaatcaaa tgctttcctt cgaccttttg ccctaatgtg 3005101 gaaaaaccgc gaagttcgtc caatctcttt actctcctat cgaatatcct gtcactatca 3005161 atagagaaag gatgatacca tgagcgaaaa tcgtcatgaa aatgaagaaa acagacgcga 3005221 tgcggcagtg gcaaaagtcc aaaacagcgg taatgcaaaa gtcgtggtca gcgtgaacac 3005281 agatcaggat caggcacagg cgcagtcaca agacggagaa gactaatgaa cgaaaacatc 3005341 attcctctta acagacatac tcaagagata cccactactg aatctgttat caaaaacagc 3005401 ggcaactcag aggtccatat cgacattcac attgatacaa tgccaattgc ttttgctata 3005461 ttatgctctg cattagccgc aaagcagatg acaaaagagg aattcgatat ggcttatact 3005521 caattgcgag agatgaacag agaaaataac agcagatcat ctgtaaagca aattatcaat 3005581 caagagacag aagaagagta aaaaaccgcg gcccctcggc cagcggtttt tcttctgcat 3005641 acaaaaagga cgcgactgaa tcggttactt ctgtacaatt tgaataaggt taccgcatgt 3005701 atcgtcgaag acagctattg tgacttcgcc catttttgtc ggttccgtcg taaacgtcac 3005761 gcctttttcc tttaatcggt tgtactcttt ttgaatatct gcaacgccaa acattgtggc 3005821 cgggaggcct tcggagaata tcttcttttg atactccttg gcggcaggat gttcattcgg 3005881 ttcgagtaaa agctcggttc cgtcttgatc atctggagaa acaagcgtta tccacctgaa 3005941 tttccccatg ggaacgtctt ccttttttat aaacccaagt ttttctgtat aaaactccag 3006001 tgccatgtct tgatcttgta caaatatact ggtaacaacg attttcatac tgtttttccc 3006061 tccttcgata tgaatgaagc atggtactat gctaacaatc tggctacaag caaaacaacc 3006121 cacacattta tcagaggccc tgttctgatt ttataaaatt attctatcca tcctttcagc 3006181 aaatttttaa gcggttcgtt gttgaatata agtactcgat attttccctt tcgttttgat 3006241 gttacgagtc ctgcatcctc cagtacagaa aggtgtttag ctatcgcctg tcgcgtaata 3006301 gaaaggtcgt actttgtaat aagacgtatc gtaagttcat acaacgtcag ctcgttgcgt 3006361 tcagataatt cgtctaatat aagccgccga gtcgaatcgc cgagtgcttt gaatatagcg 3006421 tctttgttcc cattcatata ttgagtataa gcaacccatt agttgcatgt caagtataag 3006481 caactgtatg gttgcgtgat atagaaactg aacctatccg gcgcaggtct gaaatattct 3006541 aatcgataag gaattaaaac cattaaaata acagtggata tgtctctgaa aaataaaaga 3006601 agacgaactt caaaagttcg tcttctacaa tcaaattcgg cacgccggcc attttaaagt 3006661 tgataactat ctctaaaccc cttgataaac aaaggagttt tcatcattaa ccgatagaac 3006721 cttccatttc gaacttaatc aaacggttca tttcaactgc gtattccatc ggaagctctt 3006781 ttgtgaatgg ctcgataaag cccattacga tcatttcagt tgcttcttct tcagaaatac 3006841 cgcggctcat caagtagaag agctgctctt cagatacttt agacactttc gcttcgtgct 3006901 ccaatgaaat gttatcattt aagatttcat tgtaaggaat tgtgtcagaa gttgatttgt 3006961 tatccataat gagcgtatca cactcgatgt tagagcgggc gccttccgct ttgcgtccga 3007021 agtggacgat tccgcggtac gttacttttc cgccctgttt tgaaatcgat tttgatacga 3007081 ttgtagatga tgtgtttggt gcaaggtgaa tcattttcgc acctgcatcc tgatgctggc 3007141 ctttacccgc aagagcgata gaaagcgtca taccgcgcgc gccttcgcct tttaggatac 3007201 aagccggata tttcattgtc agcttagaac cgatgttgcc gtcgatccat tccattgttg 3007261 cgttttcttc acagactgta cgctttgtta caaggttgta aacgttgttc gcccagtttt 3007321 ggatcgttgt ataacggcag tagccgcctt ttttcacgat gatctcaacg accgcactgt 3007381 gaagtgagtt tgttgtgtaa acaggcgcag tacagccttc aacataatga acgcttgctt 3007441 cttcgtcaac aatgatcagt gtacgttcga actgacccat gttctcagag ttgatacgga 3007501 agtaagcttg tagcggtgtt tcaaccttca cgcctttagg cacgtagatg aaagaaccgc 3007561 cggaccaaac agctgagtta agcgccgcaa acttgttatc agtcggcggg attacttttg 3007621 cccagtgctc acggaaaata tcttcattct ctttcagcgc gctgtcagtg tctttaaaga 3007681 cgatgccttg tgcttcaaga tcttctttca tgttgtggta tacaacctca gattcgtact 3007741 gagcagaaac acccgcaagg tatttttgtt cagcttcagg aataccgagc ttgtcgaatg 3007801 tttgtttaat ttcttcagga acttcatccc aagaacgctc tgaacgctca gacggtttta 3007861 cgtagtacgt aatttcgtca aagttcagtg agtttaaatc tccgccccat tgaggcatcg 3007921 gcatattgta gaaatgctca agtgatttca agcggaagtc aagcatccat tgaggctctt 3007981 ctttcatgcg agaaatttct tctacgattt cttttgtcaa tccgcgctct gaacggaaaa 3008041 tggaaacgtc cttgtcgtga aaaccatact tgtattcacc aatatcaggc atttttttag 3008101 ccatccattt tcactccaat ccttttaatt gccgccttct tctttcgcga ctcctttttc 3008161 aagtgctttc catgacaggg ttgcacattt gatacgggca gggaattttg aaacgccttg 3008221 aagggcttca atatccccga gatctataga atcatcatac tctttccctt gcatcatatc 3008281 cgagaaaatc ttagacatgg aaagggcagt ttcaatatct ttccctttaa tcgcctgagt 3008341 catcatcgaa gcggatgcca ttgaaatgga acagccttcc ccttcaaact tcgcatcttc 3008401 cacgatgtct ccgtcaagct tcattgtcag tctgatgcgg tcgccgcatg tcggattgtt 3008461 catatccacg acaatgctgt catttaaaac ccctttattt cgcgggtttt tgtaatgatc 3008521 cataatcacc tgtctgtaca atgtatctaa gtttgcatta aaagacattt gtaaaatact 3008581 cctttgtctt ttgaagagct tccacaagct tatcaatctc ttcctctgta ttatacagat 3008641 aaaagcttgc tcttgcagta gcagttacat ccagccattt catcagcggc tgcgcacaat 3008701 ggtggccggc tctgactgcg attccctccg catcaagcac agtcgccaca tcgtgcggat 3008761 gaacatcatc aaggttaaat gtgacaagcc cggcacgctc ttccggcccg taaaccgtta 3008821 cgccgtcaag ctggcggaag cgttcaagcg cataagctgc aagcttgtgc tcatggcggg 3008881 aaatctcatc aagaccgatt tcttcgagaa aatcaatggc ggcaccgagg ccgattgctc 3008941 ctgcaataat cggcgtaccc gcttcgaatt tccacggaag ctctttccaa gttgattcat 3009001 aaagcccgac aaagtcgatc atttcaccgc cgaattcggc aggctccatg ttttccagca 3009061 gggctttctt tccgtacagc acaccaacac cggtaggtcc gcacatttta tgggaagaaa 3009121 gcgcaaagaa gtcgcaatcg agatcctgca cgtcaatttt catgtgaggc gtgctttgtg 3009181 caccgtccac cacaatgaca gccccattgt catgagcgat tttcgccatt tctttaatcg 3009241 ggttgaccgt gccgagaaca ttagatacat gagacaccgc aacaattttt gtgttgcttg 3009301 tgaccgtttc tctgacgtct tctaaagaaa tcgttccgtc ttcctgcaac ggaatatatt 3009361 ttaatgtggc gccagttgct tttacagcct gctgccacgg aatgatattc gcatgatgct 3009421 ccatgtaggt gatgaccact tcatcaccag gtttcaggtt ggcgcgcgca tagcttaacg 3009481 ccaccatatt cagtgatgtg gtcgtgcctt ttgtgaaaat aatctcagcc attgacttcg 3009541 cgttaataaa cttgcggact ttttcacgcg ctccttcata accatctgtc gctctggttc 3009601 caagtgtatg gacgccccgg tgaacattgg aattgtattg gttataatac ttatccagtg 3009661 tttcaatgac agcacgcggc ttctgggaag tcgccgcgct gtcgagataa acgagatcat 3009721 gtccgttcac ttgctgatga aggatcggga actgttcacg aatatctgtg atattcatta 3009781 cttcactttc ctttcgataa cagaaactaa ttgtttctta acgccttcaa tcggaagttc 3009841 atttactacc ggtgcaagga atccgtaaat gactaagcgt tctgcttctt ctttcggaat 3009901 tccgcggctc atcaggtagt aaagctgaat agggtccaca cggccgacag atgccgcatg 3009961 tcctgcagtt acatcgtctt cgtcaattaa aagaataggg tttgcgtctc cgcgtgcttt 3010021 ttcgctaagc atcagcacgc gtgattcttg ctccgcattc gctttagaag cgccatgttc 3010081 gattttgccg attccgttaa agatagaaga agcggaatcc ttcatcacac cgtgcttcaa 3010141 gatatagcct tcagaagctt taccgaaatg gatgatttgt gttgtgaagt tttctgtttg 3010201 ctctcctctt ccgacaacaa ccgttttcgt atcgccgtat gtgccgtcac cgtaaaggtt 3010261 tgttgtgttt tcggaaatcg tgtcgccatc gttcatcagg ccgagagccc actcgatttt 3010321 gctgtcgcgt ccgcgcgcag caccgcggcg gttcacataa gttgtcacac cgcttgacag 3010381 attatccacc gcaccgtatg tcacgctggc attatcacct gtgatgacct cactgataat 3010441 attgaagaca gcgtctttcg ggtttacagt gctgatgtag ttttctacat atgttacaga 3010501 gctgtggtct tcagccacaa tcagcacgtg gttgaataga gctgtatcat tgctttcgtg 3010561 gacataaaca gcctgaaccg gcgtctccac ctgaacattt ttcggaacat aaaggaatgc 3010621 tcctccgtta acaagagccg cgtgaagtgc agttaactta tgttcgtcaa ccttcacgcc 3010681 gtccttcata aagtatttct ccaccaagtc gctgtgctcg cgtgcagcag tcagaatatc 3010741 agtgaagatg acgcctttgt ctttcaattc ttgagaaaga gaaagatgtg ccggcgtctg 3010801 gtcacgctgt acgtataatg ttttatcttc gttttcaatg tcgatcagcg cttttacttc 3010861 atcagtcaaa tcttctaatg aagaaagcgg ttcgttatcc actgtatgct tcgcgaaatt 3010921 cgtgaagttc cagtttgtga tttttgtttt gtcaggtttc ggcatcggca gatcctcagc 3010981 ttgttcaaga gcctgtaagc gcaggttctt cagccaggca ggttcttggt gcttttcgga 3011041 aaagcttttg agatactcct gatctacgga tagttttgta cctagtgtca tattaatccc 3011101 cctaacgctt acgcttcttg gccaacagtt tcgtcttcaa tgccaagttc ttgtttgatc 3011161 cagtcataac cttctgcttc aagacgctgt gcaagctctg caccgccgga ttttacaacg 3011221 cggccttgca tcataacgtg aacaacatcc ggagtgatgt agtttaacag gcgctgatag 3011281 tgagtgatca tcaggcagcc gaagttttcg ctgcgcattt tgttgatccc ttttgataca 3011341 actttcaaag cgtcaatatc aaggcctgag tcaatttcat caaggatggc gattttcggt 3011401 tcaatcatca ttaattgaag gatttcgttg cgttttttct ccccgcctga gaagccttcg 3011461 ttaagatagc gctgagccat ttcagggtcc atttcaagga actccatgtt ttcgtccatt 3011521 ttgcggatga atttcatgag agaaatttca tcgccttctt ctctgcgcgc gttgattgct 3011581 gagcgaagga agtcggcatt tgtcacaccg ctgatttcac ttgggtactg cattgcaagg 3011641 aataagcctg cctgcgcacg ctcgtccact tccatctcca gtacatcttt gccgtcaagc 3011701 gtgatgctgc cttttgttac ttcatattta ggatgcccca taatagcagc tgataaagtg 3011761 gatttaccag ttccgttcgg gcccattact gcgtggaatt ctccaccttt tatttcaagg 3011821 tttacaccct ttaagatctc tttcccttcg atttcaacgt gaagatcttt gatcgttaat 3011881 gttgaagcag ccatatctat acctccaaaa atatataatc attattctca ttttattctc 3011941 attctaattt tataacaaat gaaaagtaaa tacaactttt tatcgtgcct tgcacattcc 3012001 tcaagtttaa caaagatcag cactttatta aagcgattga aaaagaaaaa gagtggattc 3012061 ccaccctttt ttaaaagatt gattttctca ataagctccc gcagaaatcc gcttgctttt 3012121 ttcataatca agctctctct gccgctctac tttcattctt gtttccagcc ggcgtccata 3012181 ttcctcgtat ccaattccgt gtgacagctg catcgctttt tccatttctg acgtataatc 3012241 gaggttcagt ctgtcctggc tgctgcaaat aatgaatcaa tcccttcata tatttgcttt 3012301 ttattgtacc agtgctgcgt tggatgccgc aaaaacgatt tggcgtgaaa tagcggcaga 3012361 tgagacgaaa gcatcctttc agaacaaatg agaatggttt ttcggaatat tccttctctt 3012421 aatgcgtggt gtttccgaat tcctcaatgc actgttgaac gactgtcacg ccttggctga 3012481 aagctgcgcc gcctccaaat gccgctgcca cactgacggc ttcgagaatg ttttcttctg 3012541 acgctccctg atcaagacag ccttttgtat gatagatcat gcaatattcg tcctgagcat 3012601 tgatggcaat tccgagggcg atcagctgtt tttctctttc agtcagagaa ttcccggcaa 3012661 agcactgttc agtaaattcg ttaaattttc ttcccatcag cggcatcttt tgttcaaatg 3012721 tgcctaaacc atgtttatat tgttttaacg cgtcctgcat gcttcctctg tcttgattca 3012781 aagaaaatcc ctccatctgt ttaacattcc tttttattat gaacagcttt taggaaaata 3012841 cgcgaaaaaa accccggaat tctcatccgg ggtttcagtc ttattcagat acaggaagca 3012901 cagctccgtc gtattttttc tcgatgaagt ctttgatctt tttagagtga agaacttcca 3012961 tcagcgcttt gatttttgca gaatcttctt cgccttttct tactgcgatg atgttagcgt 3013021 atgggttgtt tttcgttgat tctacttcaa ttgcgtcttt tttaggattt aatttatttt 3013081 ggatcgcata gtttacattg atgaagaccg cgtctccttc tttgttttca tatgcttttg 3013141 ccgttaattc aggcgctact tttttgaatt caaggttttt cgggtttttc ttaatgtctt 3013201 tcaatgttgc gtcaactgtt tccactttag aatcaagagt gattaatcca gcgttttcaa 3013261 gcattgcaag catacggcct tgttcagcaa cgttgtttgt cagaatgatt gtcgcaccgt 3013321 ctggaaggtc tttcagtgat ttgtatgttt tagagtaaat accgaatggc tctaagtgaa 3013381 cagcgccggc attcacaagt ttgtaatctg tgttttcttt catttcttgc tcaaggtaag 3013441 gaatgtgctg gaagtagttc gcgtccactt ctttatcagc taaagcttta ttgtacattt 3013501 tgtaatcact aagcactttc actttcagcg tatagccttt ttctttcagc aatggttcag 3013561 cttcttttaa aatttccgca tgcggtgttt ttgttgccgc aacgacaatt tctttcttgc 3013621 cggattcagc gccgttattc gaaccgcagg cagccataac tcctgcaaat acaagcagta 3013681 atgcacccaa aaatagcttt ttcaatgtaa atcctccctt atcgtttgtc tataatattt 3013741 gttattagat caccgatgat ttgaataata aacacgatga ttaaaataaa cacagtagca 3013801 acgaaggtaa catcagcgtt attagactga tatccttcta cgtacgcaag gtttccaagg 3013861 cctcctgaac caatggctcc ggcaattgcc gttgaaccga ttaaagcgat ggctgtaacc 3013921 gtaatgccag aaataagagc aggcattgat tccggaatca gcactttgaa aataatcgta 3013981 gacgttttcg cgcccattga tttagctgct tcaatcacac ctttatccac ctcacgcagc 3014041 gcgatttcaa caaggcgcgc gtaaaatggt gccgagccga ttaccagcgc cggcaatgcg 3014101 gcgtttggcc ctaagatcgt gccgactaaa aatttcgtaa aacctaatag taaaataatt 3014161 aaaataagga acggaatcga tctgaatatg ttaacaacgg ctgcaatcac tgagttgacc 3014221 gctttattct gccagaggct tcctttgctc gtcagaaaga gcagcaagcc gaggatgacc 3014281 ccgatgacaa aagcaaacag taaagaaatc agcgtcatat aaagtgtttc atatgtcgcg 3014341 ttccataatt cagttaaatc aacgttcggg aagtattttt caaacattcg tgatcacctc 3014401 tgctttcacc tgtttgtcat taatgaatcg gatcacgttt tgcacttctt cctcgtcccc 3014461 gtcaatgtgg atgaacagtg aaccgtaagc cccatccttc gtctgcgaaa ttttcccttg 3014521 cagaatattg acgctgacat tgaagtttct gatcatctct gtaatcagag gctgttcagc 3014581 tgactcaccg acaaatgtga gctgaaccat ttttcctgat gctgtatcat caagaaggtg 3014641 ctgaagcgtc tctttcgttt cttccggctc tgtcacctgt tgaacaaatc gttttgtcat 3014701 ttgttccttt ggatttttga agacatcgag aacctcgcct tcttcgacca ccttgccgtt 3014761 ttccatgacg gcgactctgt tgcagatttt gcgtatgaca tgcatttcgt gcgtaatcag 3014821 cacaatcgtc aaaccgagtc tttcattaat atcggacaat agatccagaa ttgaatctgt 3014881 cgtttgcgga tctaatgctg atgtcgcttc gtcacaaaga agaaccttcg gattgtttgc 3014941 aagcgctctg gcaattccga cacgctgctt ctgaccgccg ctcagctggg acggataaga 3015001 tttttctttt ccttctaaac ctaccagttt aatcagttca ttggcgcgct tgatccgctc 3015061 gctctttttc accccggcaa tttctaaagg aaacatgata ttatctctga cagtccgcga 3015121 ccaaagcaaa ttgaaatgct ggaaaatcat actgatctca tggcgtgctt ttcttaaacc 3015181 gcgtccattt acttcattaa tcttggttcc cgccacttcc acggttcctg aggttggttt 3015241 ctcaaggccg ttcagcagac ggattaagga actcttacca gctccgctat atcctataat 3015301 tccaaaaatc tcaccttttt taatggaaag cgagacgttt tggacagcat tgacatctcc 3015361 atgtttcgac ttgtaaactt ttgaaacatc ctgaagattg atcaaagcaa tcacctgcct 3015421 taacactatt ctaagaaatc ttccggtttt ttctgcaaaa gaaaagcctt tctgcacact 3015481 tgagcagaaa ggcttatata aaatgccttt ctctcatctt tcaaagctga acgcttcgtg 3015541 tgaattggca ccatttcaac agtgttgatg gttgccgggc ttcatagggc acttccctcc 3015601 acctctcttg ataagagaaa tatatagtct ttttcgtccg gaaattctta atgtagaata 3015661 gcacggcgaa tgattaaatg tcaataaaat aaatgatgtc aacttttact attataataa 3015721 tttattattt tttaattttt taaaatcctc tgaaaaaatc catttgtcag ccagagaatg 3015781 gcttccagct ttaacagggc cctgaatgac ccctttactt tgaggcttcc gctctgaata 3015841 aggtgctgaa gggaaatgtc tccgtgcaat aaatcaataa tttccgtttg gtttccgtaa 3015901 aaggtcaggt tggacgtttg gggcggagaa acttttttca tttctccctg ttcgtttatt 3015961 gagacggtta aggcttctgc ttctccttgg aaggtaatga gcaatgttga ggcattcaaa 3016021 aggggtttta aaaacagatg ctgatactca tcttctaaaa cttccgcttt ctccatatgt 3016081 acaacctcct atttgttggt catacataca catttctctc tttgtcgcaa gaaccccttt 3016141 ataaaacgaa cgacaatttc attggatatg ctgagaaata tgtcataaat gggatgcgga 3016201 agatgatttt tgtttgatca gctcatataa ataagaaacg gaatgaaatg catatcctct 3016261 ttcgaccatc tttccgcctt taaacagcag aaaacaaggg acgctttcaa tttgatacgc 3016321 ttttgcgaat gtcggagagt aattgacatt gttttgatag aaggcgacat ccggcagcat 3016381 ttctttcacc actgtcagca ttttgcttgc aagctggcag gtgccgcaaa acggagtata 3016441 taaatataga aggtacacat catcttcaat gtgatcaagt tcgtgttctt ggagttcttt 3016501 catgctatac acctcgggac tttctttcaa gaaaaatagt atggacattc agattcgcac 3016561 gcagcaatac agaagcgata tggtgcctgg gcgcagccgc tacttcctta taggctctgt 3016621 cgacatggag atggcaggct tcattaaatt cacgcttcag ctgttttctc aatttctcac 3016681 ctgattcatc agcatcaact aatatataga cgtctttatc ataaagctcg tcagccaatt 3016741 cctcgagcct cagctggctg attgttccgt ttgtgcagat aatgcgcatc ggttcattca 3016801 ggacgctttc gattttctct ttatctgatt tcccctcgac aatcataacc ttttccagct 3016861 catccatctt catcttgttc acctgccgcg tcaaatttga aatgttcaga ttgtaaaaga 3016921 aggcagtgaa attcaccgcc aacattaaca ccagccgttt tcgtagtcac aatctacata 3016981 ttttgcgtcg tctccagaga ccacatcggc tgtcttataa aatttctcat tttcaaagga 3017041 ataaccggac ttaagctcat attcattcat gcttgtcatt tggccgatca tctcattatc 3017101 atgatataac gagagccggc cattttgaaa gcggcctgtc acgtcattgg tgacatcgag 3017161 cttttgtttg tcgaaagcca tattggacac ctcccataac gttagcgtgt ccaattgctt 3017221 ttacggctat cctgttttag tcttcttgtg tcatctcttc gtattgctct gctgtcatca 3017281 gtttttcaat ttcagaagcg tcagatggct caacgacgat catccatgct ttttcgtacg 3017341 gagattcgtt gacgaattcc ggactgtcat caagatcttc gtttacttcc acaaccgttc 3017401 cgttaatcgg tgcataaagc tcagataccg ttttaacgga ttcaacactg ccgaatggct 3017461 cgtccgcttt gatttcagcg cccacttcag gaagttcgac aaacacgatg tcgcctagtt 3017521 cggactgggc aaaatgcgta attccgattc tggctttttc tccttcaact tttacccact 3017581 cgtgttctcc tgagtaacgc aaatcttttg gtatgctcaa ttgaatccct ccatttttta 3017641 cagcactaca ataagaagat accacacttt tcaaaaaaaa tttacattaa gcccagtttt 3017701 cttcaaattg gtcttcttta aatccgacag tcactttttc gccgtctgtt gtaagcgggc 3017761 gtttaattag cataccatct gaagccagca gttcgagctg ttcgtcctct gacatatgat 3017821 acagcttttc cttgagattg agctcgcggt atttcatgcc gctcgtgttg aaaaatttct 3017881 tgagatccag cccgcttttt tcataaagcg cttttaattc ttctttgctt ggcggctgct 3017941 cagcaatatg tatttcgttt atttctttcc catgctcttc aagccacttc tttgctttgc 3018001 ggcacgttcc gcatttaggg taccagtaaa aagttaacga catcttcttc cccctcaata 3018061 aaataatcga ggttatttta acacagtttg ttttaaaaac ctaaaacagt gcttcttaaa 3018121 aaagagctcc gcgcatgcgg agctcatggc caatcagaca gtatatttct cagcctcaaa 3018181 aatgcctgcc gccgcctcgc gttttttctg aatcacgttt ttaggcgtta cgcgtgtcag 3018241 cttgcgcaga gcggaaagca tcatgcggag tgaatctcct tcttccattg cgataaggga 3018301 ttcctttgca tgcgcttcga tttcgttaaa ggcctcttga acgaaaattt ctgtgtacag 3018361 caccttttgc gctgcttttt cagcgccttg tgcggcaatg gccttttccg ttctgagcac 3018421 ggctgattcc attgcgtata cattgctgac gatatccgct acgttcacga gaatttcttg 3018481 ctcacgatcg atcgcttttc cgtatttttg cgcggctagg ccggcagcaa acaacgcaat 3018541 ttttttggct tgcttgacga tatatttctc ctgctctaag acgccgcttc caggctcttc 3018601 aggcataagc atcatgagtt cttcctgcag cgactgcgct ttttcgaata aaggcagctc 3018661 gcctttaagc gcttttttca ggaaggtgct tggcacgatt aaccggttga tttcgtttgt 3018721 gccttcaaaa atccgattga tccttgaatc cctataggcc ctttctactt cgtattcctg 3018781 cataaagccg tagcctccat gaatctgcac gccttcatca acgatataat caagcgtttc 3018841 agagccgaat accttattca gagagcattc gatggcgtat tccgcaatcg atttggcgat 3018901 ttgccggccg tccttgagat cttcggccgt gaactggctc atattgtctt caaacagccc 3018961 gacggttctg tatacagagc tttccatcgc atacagcctt gaggccattg tcccgatttt 3019021 ttcctgtgtc aatgaaaaac cagcaatcgg cgttttaaat tggcggcgct gatttgcgta 3019081 tgccgcagac agctcgatga cgcgtttaga tgcgccgatt gtgccaaccg ccagtttgta 3019141 acggccgatg tttaaaatat taaaggcgat gacatgccct ttgccgattt ctccgagcag 3019201 gttttccttt ggcacttcag cttgatccag aatgagggtt cttgtcgatg atcccttgat 3019261 tcccattttc ttttcttccg gtcccgtgga gacacccggg aactcttttt ctacaataaa 3019321 ggctgaaaac ttgtcgccgt ctaccttagc gtaaactaca aatacatcgg caaaagcaga 3019381 gttggtaatc cactgttttt cccctgttaa tacataatgg gttcctgctt cattcagcac 3019441 agctgttgtt tttgctccaa gtgcatcaga cccagagcca ggctcagtca gagcataagc 3019501 ggcgatcttt tcgcctgaag cgagtccagg caaatatttt ttcttttgtt cttctgaccc 3019561 gaaaaagacg atcggcaagg aaccgatacc gacatgcgcg ccataagaaa gagaaaagct 3019621 tcccgcacgc gaaaatttct cagtgatgag tgccgagctg attttatcaa ggccgagccc 3019681 gccgtattct tccggcacat cggcgccaag cagccctagt tcgcccgctt tcttcaacag 3019741 tctgacagaa tgctcgaatt gatggttttc gatatcatct atatgaggga gaacatcttg 3019801 ctcgatgtaa tcctctgttg ttttcgcaat cattttatgc tcgtcagtga aatcctccgg 3019861 tgtatacatt tgatcgtatg tgacatcctc gattaaaaat ccgccgcctt tttgtacgtc 3019921 agccgctttt tttgccattt gtttttcccc ctttagcata attcaaatac accggccgct 3019981 cccattccgc cgccgataca catggtcacg actccaaatt gctcgtttct ccgtttcatt 3020041 tcatggatga gtgagagtgt aagctttgtg cccgtacagc caagcgggtg tccaagcgcg 3020101 attgcgcccc cgttgacatt cactttttct tcatcaattc ccaattccct gattacttga 3020161 atggcctgtg aggcaaaagc ttcattcagt tcaaacaagc cgatgtcctg cagctgaagt 3020221 ccggcaagct tcaaagcgcg cggaatcgct tccaccggtc cgattcccat cacttccggc 3020281 ggcacgccgc ctaccgcaaa ggagcggaat ttcacaagcg gcgccaggcc aagagcatcg 3020341 gctttttccc ggtccatcag catgacagcc gccgctccgt cactcgtttg tgaggaattg 3020401 cccgcagtca ccgtcccgtc aacggaaaag gccgggcgca atgtcgataa gatgtctgca 3020461 gtcgtttgcg ggcgaacacc ttcatcctga gaaaacacaa actgtttttc cataggctta 3020521 tggtcttctc cgatttctgt caccgtcact tcgacgggta caatttcatc tttaaatttt 3020581 ccttctgcaa gggctttagc ggcgttttga tggctgcgaa cggcaaacgc gtcttgatcc 3020641 tcacgggaga cgccgtattt tttcgcgact tgctcggctg tgtgccccat gctcatataa 3020701 tattccggtg ccttttctgc caaagcaagg ttcggacggg taacatgccc catcatcgga 3020761 acttgcgaca tggattctgc tccgccggcg atcgctgtat cgtaggcgcc cagcataatt 3020821 ttttctgctg catacgcaat agactgaagg cctgaagagc aatagcggtt aactgtaatc 3020881 gccggaaccg tgtacggcag gcccgcgagc gcaccgatat ttctcgccat attaagcccc 3020941 tgctccgctt caggtgttgc acagccgata atcaagtcat caatattgcc ttcgtagccg 3021001 cctgcccgtt tcagcgtttc ttttacacaa atcgctccca aatcatccgg gcgaacggtg 3021061 gccaacgatc ctttttttgc ttttccaacc ggtgttcttg cacctgacac aatgactgcc 3021121 tctttcataa gctccctcct aattccgtaa aggtttacct ttcacaagca tatgctgcat 3021181 tctcgcttga gattttgcct ctcctgacaa actcaaaaac gcttctcttt cgatctccaa 3021241 taaatactct tcatcaacct ctgtaccaaa cggcactttt ccgcccgcaa tgacataagc 3021301 gagttttttc gcgatcttaa aatcatgctc agatatatag ccggacagct tcatctgctc 3021361 agcgccaagc aagagtgccg cataaccggt ttctcccggc accttgacct tttcttttac 3021421 aggcggccgc cagccggtat cgtataaaga tgcggccagc tgcttcgcat cgtataacag 3021481 gtggtcttga ttcacgctga tctgatccgt ttcttttaag atgttcatct cacgagcctc 3021541 ttgagcggaa gcggacactt tcgccatcgc gattgtttca aatgttttca ttgccgcatt 3021601 catcggatca tggccgcggc gaagatggtt gatgtacagc tctttgttac ctcctccgcc 3021661 agggatgagg ccgacaccgg attccacaag tcccatatag gcttcgcttg ccgcttgaat 3021721 gcgcgccgcc ggcaggcatg cttccgttcc tccgccgagc gtcatgccaa atggcgcggc 3021781 gacgaccggt ttcgcactgt atttgatctt catcatcgtc tcctgaaaac ggcggatcac 3021841 aaaatcaact tccaaaaagt tgtcatcttg gacttccatt aagatcatgg cgagattcgc 3021901 gccgacgcag aaatttttcc cttgattgcc gatgacaagc cccttgtaat tccgttctgt 3021961 ttcctctaat cctttgtgga tcatttgaat gatatcgagg ccgatcgcat tgcttttcga 3022021 atgaaattca agaagggcca catcatctcc aaggtcaatt aagcttgctc cgctgttttt 3022081 cgcaatcacg ccttttgttt ctttaagtgc ttgtaaatga attcgttttt tgttttcttt 3022141 cacggctctg tattcgccgc ggtcataata aaataccgtt ccgttctctt tgatgtagaa 3022201 ggtttcattt cctttgtcca gcatctcttt tatccagcca ggcatatctg ctccaagctg 3022261 ctcaagcttt tccgctgact gcttgaggcc gatggcgtcc cacatctcaa aaggtcccag 3022321 ttcccagccg aatccccact tcatggcttg gtcaatcgca tgaatatcat cggcaatctc 3022381 gccaagcagc tcggctgagt aaagcagggt ttgagaagtg atattccaca gcaaacggcc 3022441 ggccctgtca tccgaataaa taagcgcttt cattttggct tttgtccctt ttgcctgttt 3022501 tgccgcttca agtgccggtg atttcatttt tgtccgctcg ccgtaagtaa gcgtcactgg 3022561 gtcaagctca taaatcgttt ttccttcttt tttataaaag ccttggccgg ccttgcttcc 3022621 gatccaccct ttttccagca tatcgttcat gaagcttgga atgcgaaaca cttctttttc 3022681 atcgccatca gctttgtcat acacatttcg ggcaacgtgg gcgaatgtat cgaggccgac 3022741 cacatcaagc gttctaaagg tggcgctttt cggcctgccg atcagcggtc ctgtgatcga 3022801 atcaacctcc ccgacctgat aaccgccttt cagcatttct tggactgtca cgagaagccc 3022861 gtaagtcccg atgcggtttg cgataaagtt cggtgtgtcc tttgctgtaa caacgccttt 3022921 cccgaggaca ttttctccga aagctgtcat aaactttaaa atatcaggat ccgtttcctt 3022981 aatcggaatg atctctagca gctttaaata tcgtgcggga ttaaaaaaat gcgttccaag 3023041 aaaatgggct ttaaaatcat ccgaccggcc ttcagccatt tcctgcactg atatgccgga 3023101 tgtgttgctt gagacgatgc ttccagtctt tcgatgttca tccacaagag cgaaaatttt 3023161 ctttttgact tcaaggtttt cgacaacgac ctcaataatc caatctgctt ctttcagttt 3023221 ttctgcatca tcctccagat tgccaggtgt aatataggag gtatttttcg ctgatgtgag 3023281 gggagcgggc ttttgtttca gcagtttttt catcgcctgc cggctcagcc tgctgcgcac 3023341 ctccgaactg tccttcgtca gccccttttt ttcctcttcc tttgtcaaat cgttcggcac 3023401 aatatctagc agcaggacag gaattccgat gttagccaaa tgcgccgcta tcccggaacc 3023461 cattaccccc gatcctaaaa cggctgcctt ccgaatgtgt ttgtgcatga gatatccccc 3023521 ttgaacattg aatgaatagt cattcatttt ttgactaaaa aaaatgaaac ccgtttcttc 3023581 tttcatctta aaagatttcc ggttcgactt caatagctaa tttgttattt ttttgtatga 3023641 agcctataaa agtcgggcaa cttaagcccg gaggtgaagg gaatggtacg agagaaaaaa 3023701 aatccgtctt cagcggcagt cagcgcggcg agcgtaaagg gagatgccgg tccgactcag 3023761 cattacggcg gcggaaaacg gacaagtcaa aatcagcagt ataaaaaaca taacatggga 3023821 caatcataat gcagctgctt cccacggctg ctttcacttt ttcaaaattc cttttaacac 3023881 aaacgctgca ttggcaggcc gttcggcaat tcttctcata aagtagctga accagtccgt 3023941 tccatatggg acatacacac gcattctgta gccttccttg gcgagttcct tctgacgctc 3024001 cggcctgatg ccgtatagca tttgaaactc aaattgcgat gcggggattt gatgttcggc 3024061 gacgagctgt ttcgtaaatg caatgatgtc atcgtcatgt gtggcgacag ccgtgtagtt 3024121 cccgcttaac aactgcagct ttattaagct ctgaaaatga aggtccgtgc ctcttttgtc 3024181 gggaaacgct acagccgcag attctttata agcgcctttt acaagtctga gattcggctt 3024241 taagtcccgc atctttctga tatcttctgc cgcccggtac aaatacgcct gaatgaccgt 3024301 gccgagcttc tcaaattcct gtttgcattg cctgtaaata gaaagtgtct gttcataatg 3024361 agaatagtct tccatatcaa tggtcacagc aacatcatat tgcttcgcaa cggaaagaat 3024421 ggcgcgcaaa tgagtaagag caagttcttc tgaaagatcg agcccgattg aggtcagctt 3024481 aagtgaaagc tctgaattca attgatgttc ggcaatggct tgaatggctt tcttgcattc 3024541 ctctgcgact tggtttgctt ctttttccga agctgcatac tcgcctaaat aatcaattgt 3024601 tgcacacaaa ccggatctgt ttagcctttt gacggtctta accgccgatt caatcgtatc 3024661 ccctgcgaca aaccttcgtg ctccaagccg cgttccgtat gcttttgcga acttggtaag 3024721 tgttttattt tgagataaga ataaaaacac atgtctcaac atccgactcc ctcccgccgt 3024781 catcttcaaa acacctgtat ataactccca gtctgaagga aactataaaa tgaacagaaa 3024841 ccaaaggagg atcacaatgg ataatcagca gcaatctcaa atgccgcctt ccgttatttc 3024901 gacaaaggat catttgtatc tcaatgacat gctgaactgg aatttgctcg cgatgaaaaa 3024961 agcgcatttc atggcgcagc agtgccagga tcaaacgtta aagcaagaac tcgaccgcgt 3025021 cggacacatg catcatgatc actatcaaag aatattaaag cacctgcagc caggccagca 3025081 gcagtccggc tacatccaat aaggaggcgc cagaatgaat cagcaaaatc aaaaaatcag 3025141 caacccgcag acacctgtac cgacaacatc ggaaatgaat gacagagatt tcgtcaacga 3025201 attgctgaca accgaaaaat acatgacaac agcttattgc actgccttgc acgaattcag 3025261 ccacgagtct ctttatcagg atattcaatc catttttgat gagtcacaaa aagcgcaaag 3025321 aaaactatat gatctcatgt tccaatatgg atggtattct gttgaagcgg aggattcaca 3025381 aaagctgcag cagtcctatc aaaaattcca gcagaccatt cagcagcagt ctccttatca 3025441 gcaataacaa cattagtaaa aaggatacga tgttctttcg ggcatctatc ctttttttgt 3025501 gtaaaatcag ttgacttttc atttacgctt atttatattt aataagcatt aactattttg 3025561 tcattaaaat atatatacag tgtatgtaac agaggggaaa tgaatatgaa gagtgcggat 3025621 cagttaatgt ccgatattca attatcgctt caggcgctct ttcaaaagat acagcctgaa 3025681 atgctggaaa gcatggagaa acaaggtgtc accccagcgc agctgtttgt gctggccagc 3025741 ctaaagaaac acggcagcct caaagtttct gaaattgccg agcgtatgga ggtgaagcca 3025801 agcgcggtga cgctgatggc agatcgcctt gaacaaaaaa atcttatcgc cagaacacac 3025861 aacacaaaag acaggcgagt gattgatctc agtcttactg acgaaggaga cataaagttc 3025921 gaggaggttt tggcgggcag aaaagccata atggcgcgct atctttcctt tttgacggag 3025981 gaggaaatgc tgcaggcggc gcatattaca gcaaaactcg cacaagcagc agaaacggat 3026041 gaaaagcaaa acatgaaaag aggaaacgga tgaaaatgag taaagaaggc aaacaatcaa 3026101 aacgaacgtt attaataaca ggcttaatta ttgccatgtt tttttcagcc cttgacggta 3026161 ccattgtcgg aacggccatg ccgaaaattg tcggtgatct gggcggtttg agcatgatga 3026221 cctggctgac aactgcatat ttgttaacat caacaaccat tgttccaatt gccggtaaac 3026281 tggctgattt attgggacgc cgcattgtct atgtatcagg tttgattatt tttatggccg 3026341 cttctgcttt gtgcggaatg gccaacaaca tgacggaatt gattatcttc cgtggactgc 3026401 agggcatcgg cggaggcatc atgatgccga tggcgatgat tgtcatcggt gacttgttca 3026461 caggaaaaca gcgtgctaaa ttccaaggtg tctttggcgc aatttacggg ctggcttcag 3026521 tgattgggcc gcaaatcggc ggctggattg tagactcgtt aaactggaaa tgggttttct 3026581 atattaacct gccagtcgga attattgcgg ttatttttat tgccagggga ttacagggac 3026641 gccagcagac tggtccgatc aacttcgata tcgctggtat tttcacaatg attgtcggtg 3026701 tggtcagcct cctgctcgcc ttaagctttg gcggaaaaga ttatgcatgg gattcatggc 3026761 agattcttgg gttgttcgct ctcgcactga tcggcattgt cagctttatc atcgtagaat 3026821 caaaagcaaa agagccaatc ctgccaatgt atttatttaa aaacagaaca tttacatttc 3026881 taaacttgat cggcttcttt atgagtatcg gtatgtttgg cgccattacg tttgttcctt 3026941 tctttatgca gggaattgtc ggtgtaagtg cgtctgaatc gggtacaatt atgacaccga 3027001 tgatgatttc tatgattatc acaagtatca tcggcggaca gcttgtttat aaaattggga 3027061 ttaaaccgca aatcattaca ggcatgctgg ttatggccgg cggattcctg ctgttaacga 3027121 cattggatct cgacacgagc aagcttgtcg ctacatcttt tatggcgatt attggtctgg 3027181 gaatgggtct tgttatgccg attctgacat tggctttaca ggaaagcttt tcgaaggagg 3027241 agcttggagt tgtcacttca tccagccaat tcttccgttc tatcggcgga acattcggca 3027301 ttaccatgct gggagccgta atgaatgcga gatcaggaaa tctattaaca gataaattgg 3027361 ttccatattt agactctctt ccggcacagg caagctcgtt tgccgcccag ctaaagggta 3027421 tgattgatac aaatccgcaa gggctgctgc aatcactgtt cagtccggac gcggtcaaac 3027481 aaatccctgc ggctttctca tcccatattg tgccgatttt aaaaacatcg ttgatggatt 3027541 cgctccacag cgtgttttat acgggcctga tctttatcgc agtcggagcc gtattcacct 3027601 tgttcttaaa acctatcaag ctatcaaata agaaagcgga agaccaacaa gaaaaagaga 3027661 aggcggcaaa agccgttgaa tcaccttccc attaatagag caccccgcgg gtatcaatcc 3027721 gcggggtttt ttattcaatc atctgggctc ttccatttcc gaaagaccaa tcctcatcct 3027781 gatttccggc cagcatgata aacacatctt cttttcttac accaagctcg gaatgaatcc 3027841 ggctcgcgat tgagcggtaa agtgcttttt tctgttcagt tgttcttgac tgtttcagtg 3027901 taaaatgaat gtatatcagt tcatcagtac gctcgacttg gagataaaat ggatcataaa 3027961 aaaattcgct tttttcatat tgtctgatga cttggaaata gtcatcttcc ggcacattga 3028021 tttcttcaat catcgattgg tggatagtcc tgctcagttt ttgaagccac acttcgcttc 3028081 ttcccgaccg taaatgaatc tgtacaaatg gcatctcccc gcatcccttt ctttacagcg 3028141 tctgtccgct gtcaattgtg ataatttggc ctgtgagtga ttcctgttca attagtgaac 3028201 aaatcaattt ggcaacatca tctggttcag caatacactg cagcagcaaa gagccgatca 3028261 tgcttttcat tttttcttcc cgtccggccc accatctcgt tgccacagct cctggtgcta 3028321 caccgctcac tctgatttca ggcgctaagg cgtgggccaa tgatttcgtt aaaccgtgca 3028381 ccgctgattt tgatactgcg taaggcattg atgagccggc accagttatc cctgcgatgc 3028441 tgccgacgtt tacgatcgcc ccgtccttgc ttttcttcat gaacggaacc actgcccgcg 3028501 cgcagaaaaa catccctttc acattgacgg catacagctc atcctagacg tcttctgtcg 3028561 cagcctcaag atcatccatt ggaatatgcc gtgtaatgct ggcattgttg actaaaatat 3028621 caaccgtgcc gtgtgtgttc acgattgctt gaatcatatc ctgcacgtcg ctgtttttgg 3028681 atacatctgc ttggatggcg aaggcttgcc cgccagcttt ttgaatcatt tccactgttt 3028741 cctccgcttc tgattgcgag cgtgaataat tcaccgccac aatcgcccca cgctttgcca 3028801 attccatact ggctgctttt ccgattcctg tgccgccccc cgttacgaga gctattttgt 3028861 tcaagacatt cattgccgcc actccttgct gttgactaaa gtatatttct gattccattg 3028921 taatccagct ttgatgttac gtataatgat tgttaaagat actagatatc actcagattg 3028981 atagtaaacg aacggaggag ttcaaaatgg aaagcggaga tttacgtgtg tttcaaatgg 3029041 tagctcgtga agggaccatt acgaaagcag ccctgcagct tggctatgta caatcgaatg 3029101 tcacggccag aattcaacaa ttggaagctg agctgggtac cacactgttt ttgcgccata 3029161 atcggggcat gacactttct gcaagcggaa aattgctgct ggactacgca aataaaatta 3029221 taggccttct tgatgaagcg tctaaagcgc tctcatcctc cgcagaacca agcgggccgc 3029281 ttatgatcgg ctgcactcag acaaccgccg cggtaaggct tccaaagctt ctggcatctt 3029341 attatgaaga acatccaaac gtccagctgt ctttaacaac aggacatacg caatttctcc 3029401 ttgataaagt tcttcgttat gaattggatg gcgcgtttat cggatgcgaa tgccatcatc 3029461 ctgagctcga atcctatcct gcgtttgagg aagaaccagt agttgtttcg gctgcctccg 3029521 tgcccgatgt tgaggaagcc atcacaaagc cgattctcgt ttacagcaca ggctgttcgt 3029581 atcgagaaac acttgaaaaa tggctgcgtt ccgtcggtgt cacacagccg gtcattatgg 3029641 aatttgggac gcttgaagca attatcggcg gggttacagc aggtcttggc atctcgttgc 3029701 tgccaagaac ggttgtgcag aaacatgaag cagaaggatc aattcgattg tacccgctgc 3029761 ctgaagctct cagccagatg aaaacagagt ttattgttcg aaaagattcg tttatcagca 3029821 gcgcgctgag aacctttatg gattccttta cgccagttaa aacggctgaa tcacaaaaaa 3029881 gcagtctgct ataatgaaca gactgctttt tggctattgt ttgtttcgat gcgcttcatt 3029941 taattcctta atatgctgaa tgatctcttt aatgccctgc ttcgcgtcgg ggtatgtcgc 3030001 attccaatgc ttagcgagcg gaggcatgct tttggctata tgggtgtaca aaatccattg 3030061 cttcacttct tcttttagct catcgtttgt ttcaccaagc agaagctcag tatacttctc 3030121 cagcaatcca tcaagctgct cctgaagttt ttgttccatt ttccatcttc ctttcgaaaa 3030181 aacagcaagg agctttctca attgaaagct ccttcgctgc gttatttatc catgtgatgt 3030241 gaaagccgct tcctggacaa tgcatctgcc cctgccatga ggaatgcaaa gaggcgttcc 3030301 gaagagcggg tcctgtgtaa cctgacagtt catagaaaac acattttgca caagatcaca 3030361 agtgatgacc tcttccggac ggccttctgc ataaatccgt ttatctttta tggccacaag 3030421 atgatgcgca tagcggcacg ccaagtttaa gtcatggaga accataacaa tcgtccggtc 3030481 ttccttttca ttcagctcaa acagcaaatc aagaatttca atttgatgcg tcatgtctaa 3030541 atacgtcgtc ggctcgtcaa gaaggatgat atccgtttcc tgggcaagcg tcatcgcgat 3030601 ccaagcccgc tggcgctgtc cgcctgacaa agaatcaacg gcacggtcag ccatgtcctc 3030661 aagctttgtt gctttaagcg ctctttcaac tgcttcctca tcctcttttg accactgctt 3030721 cagccagttt tggtaaggat atcttccttg cttcaccagc tgatgcaccg tcagcccctc 3030781 tggagccgaa ggaccttggg gcaggattgc gagctctttt gcgacttcct tcgtcggaag 3030841 cttggcaatc gctcttcctt ccagcagcac tgaaccgcct ctcggcttca tcaggcgcgc 3030901 taatgaacgt aaaagtgtcg attttccgca gccattgctg ccaataaata cggtaatttc 3030961 acctttggga attgttaaat tcaactcatc aataataacg gcatccccgt atcctaagct 3031021 cagcgtttct gtagaaattg cactcatacc cataaccgct cctttttgct ggctttttag 3031081 cagcactatg tattgcacgt tttctatata catgctttta agtcaattgt catcaatgca 3031141 aatgattccg atattcagcc atttgatatg gtcatatatc cctcattgta gcagaaaaca 3031201 ctgactttga aaatcatttt caattagttt tatggacata attgacgttt atgggttttt 3031261 tatcacaaga ttacttcttg atttctctga tggagccgtc cttcagcttc aattttaaat 3031321 cgatatgatc ataatgactg tccagattaa atgctgccag cacactgtgt atcacttctg 3031381 tttcagccat ttggtctgtc acggaaagct cgctcaaaat cattttcatc tcatctaacg 3031441 cttcttctcc ttcctgattg acaccggaga gcttatcctg tatttccgct ttttcctgag 3031501 tcccgttctt tgtatagatt ccttcataac ggttatgctc accatccccg tagctcacac 3031561 gaagcgaaaa attactgtag ggaacggact tcagctgggt gacggctgta ttttctcctt 3031621 ctgcctgatg ctggtcttca ttgaaacggc agcccgcaat cagaaccact gcgagacata 3031681 cagccccggc tgctctgatc aaatgcatat gtttcccccc tgtaggattc catttatttt 3031741 aggtatatcc agagaatgaa atcctcattc agagaagaat tgaaaaagcc ggggcattta 3031801 acgccacggc tttttcttta agattcggtc atttgtaaaa aggtttcggc gtcacgcaca 3031861 gccagcttga tggcattctc ccagaaatcg cgctttgtga tgtcagcgcc caaatgcttc 3031921 atcgccaaat cctccactgt catagaagcc gtatcgcgca atagcgccat atacttctct 3031981 tcgaatgtgt ctttttcttc aagcgccaac gcgtaaatac caagagaaaa caggtagccg 3032041 aatgtataag ggaaattgta aaacggcacc ctcgtgatgt gaaaatgaag ctttgatgcc 3032101 caaaaaagcg gatgatattc ttctaacgca ttgcagtatg cctctctttg cgcctcttcc 3032161 atcagctcat tcaagcggct ggccggtacc actccccgct ttcgttcctc gtagaatctc 3032221 gtttcaaata gaaatcttgc gtgaatgttc atgaagaacg caacgcttct ttgcacttta 3032281 tcctccagaa gaacaagctt ttcttccctc gtctcggcct gctggacagt cgcgtccgcc 3032341 actatcatct ctgcaaacgt tgaagctgtt tctgcaacgt tcatggcgta ggaacggttt 3032401 aacggcctga cgttgagcat tgcttcctga tggaacgcgt gcccgagttc atgcgcaagg 3032461 gtagagacat ttgaggcgct tcccgaaaat gtcatgaaaa tccgggattc cccgctgtcc 3032521 ggaaaactgg tgcaaaagcc gccgactctt tttccgctcc tgtcttccgc ctcaatccag 3032581 ccgtcccgaa acgctttttc agtgaatgag gacagctttt tgccaaacgt tgaaaactgg 3032641 ctggtaatga tatttgcggc ttcatcatac gaatagacct ttccgtcaga accgatcggt 3032701 gcctcgacat cgtaccagct gagtttttca aggccgagca tggatgcttt ccggttcaaa 3032761 aactgaacga acggcttctt gttttcagtg atgacctgcc acatcgtatc aagtgtttct 3032821 tttttcatcc tgttaatttg cagcggttcc ttcaggacat tctcccagcc gcgcgcttta 3032881 taggtttcaa gccggaatcc cgccaaatga ttcagcgtgc tgctgaaaat atcttgcttg 3032941 ctctcccaag cttggcggaa acgttcatat actgtttttc tgacagtacg gtcttgatga 3033001 tccatcatat tctccgcctg accgacagac aattgcttgt tttcaccgtt ttcctcatac 3033061 gggatcgtca ttttcccgac aaccatattg tataagtcac tccaagcgtg atatccgtcc 3033121 accgcaaggt ttccgatcag tttttcctta ccggggctaa gcttttcggc aaccctctgt 3033181 cttctttcat ttaatatgta agaaacatcg cgcaatcccg gttttgttaa caattcattc 3033241 cacacgtctt gattaatgtc cacaagttta tgatctaatg taacgagcga cgattgaaaa 3033301 tctgcggaaa gccgattcat gaggcctgat gctctatagc cttttgatca ttgatattct 3033361 gggcctggag gcaagcaaca aaagcgccgg cctgctgaag cttgacggat gtctgttcga 3033421 ataaatcaag caacgcggtc agcccttcag cctcttcagg cgattcaggc acctgaaacg 3033481 catcagtcct gtcttgaaat gcacgcagac tttgtgacag cttctcaata taacctttga 3033541 attcttccga ttggctcccg cccttaaaaa atgaatcaag atcccatctt tggcctaccc 3033601 cttgcagcgc catatcacaa aacccctttc cttctttcgt tctattatag aacaattctg 3033661 aattattgta taaaaatttc tattacaggc gtcatttcgt gttcaggata gtacaatagc 3033721 tgtagcagtt taataggagg gttaggatga ataaaaaaat agccatcgtg acaggagcgt 3033781 ccagcggctt cggtctgctg gcagctgtaa agcttgcccg atcatttttc gtgatagcca 3033841 catcaagaca gcctgaaaaa gcggaacagc ttcgagaatt ggctgcagca cacaatgtgt 3033901 ctgattctat tcacattaca gctctcgatg tcaccgatga acaatctata gtctcattcg 3033961 gaaaagctgt tagtgcttac gccccgatcg atttactcgt taacaacgcc ggaacggctt 3034021 atggaggatt tatcgaggat gtgccgatgg aacatttcag acaacaattt gaaacgaatg 3034081 tcttcggtgt gatccatgtg acaaaaaccg tgctgcctta cataagaaag catggcggcg 3034141 caaagattat aaacgtgagc agcatcagcg gactgacagg attcccagcg ctgtcgccat 3034201 atgtttcttc caagcatgca ttggaaggtt tttctgaaag cctgcgtatc gagctgcttc 3034261 cgttcggtat cgaaaccgct ttgatcgagc cgggctcata caagacatcg atctggtcaa 3034321 cgtcattatc aaattttatg tcggtgcctg ctgacgattc agcctatcat caatactata 3034381 aaaagatcct ttcctatgtt caaaaaaacg gagaagaaag cggagatccc caagaggttg 3034441 ccgacctcat ttatcaattg gcaacaaaac agcacataaa gaatttgcga tacccgatcg 3034501 gaaagggcat caagctcacc ctgctgttcc gatcgctttt tccttggtct gcgtgggagt 3034561 ctatcctgaa gaaaaagcta ttcagctgat ctaaattata attattataa tttagtattg 3034621 atttttattt agtatatgat ataattaagt caacagatca caaggaggac gttatcttat 3034681 gaaaactgaa aacgcaaaaa caaatcaaac attagttgag aattcactga acacacaatt 3034741 atcaaactgg tttcttttat actctaagct ccaccgtttc cattggtatg tgaaagggcc 3034801 tcatttcttt acattgcacg agaaatttga agaactttat gaccatgcgg ctgaaacagt 3034861 ggataccatc gctgagcgcc tgctggcgat tggcggacag cctgttgcca cagtgaaaga 3034921 atacactgag catgcatcta tcacagacgg cggaaacgaa acatcagcat cagaaatggt 3034981 acaagcattg gtaaacgact acaaacaaat cagcagcgaa tctaaattcg tgatcggcct 3035041 ggctgaagaa aatcaagaca atgcgacagc ggacttgttt gtcggattaa ttgaagaagt 3035101 tgaaaaacaa gtgtggatgc tttcctctta tttagggtaa caaaaaagct gaaccttaat 3035161 cgggttcagc tttttgtttt ttcttagctt gaactgcttt ctgtctgctt ggtcagtgtt 3035221 gcgttcaacg ttttcgtttt tccctttcgc agcacttgga ttgttgtttt atctccgact 3035281 tttaagtctt tgtaaaggat ctgacggata tccgcactgc tttccacgtc tttaccgttt 3035341 agtttgacaa tgacatcctc agatttaata cctgcttttt ctgccggcga atttgcttga 3035401 acttctttta cataaacacc tttgcccaat tgatctccaa acaggccgag cgtattttcc 3035461 tgataggttt caggaacttg tgacatgtca atcatctgca cgcctaaaaa cggacggtcc 3035521 accttcccgt tttgcagcag ctggtcaaca atcggctcga catcattgct tgggatcgca 3035581 aatccaagtg attccacgcc gctttcgctc accttcaagc tgttgatgcc gatgacctgg 3035641 ccgcttgcat tgattaatgg gcctccgctg ttccccggat tgatcgctgc atcggtttgc 3035701 agcacgttca tttccaccgt cccctgtgtt gtatccacat caattgtccg gttcagtccg 3035761 ctaatgatac cttgtgtcac tgtaccggaa aactgctgtc cgagcgggtt accgatagcg 3035821 attacctttt cgccagtgcg cagctgtgaa gagtcaccaa agctcgccac tttttttaca 3035881 ttcttgccgc tgatttccaa aactgccaaa tcagtaatgg tatcgctgcc gacaagcttg 3035941 gcagtttccg tttctccgtt gtatagcgta acagtcagct tgttcgcgcc ttcaacgaca 3036001 tggttgtttg taatgatata cgctttatcg ctgtcttttt tgaaaataac acctgacccg 3036061 gttccgcttt cactttctga gctggagcct cctcccgtgc cgaatgtgtt attttgagag 3036121 gtttggatat ttgagattcc gacaatcgta ggctctaaat cctctaccat atcagcgatg 3036181 tttgatgcgt tcgttatcgg cgccgttgta aaattatcag actgcacctg tttatttgcg 3036241 gaagcggttt cggtcgcctg attttggtct gacggcagat aaggcgcgat gccaagcatg 3036301 aggcccccgc cgataatacc gcctaaaatc gggctcagcc atgcggctct ccgtttcttt 3036361 tcttttttca cagccgtttc ttgcttttcc atttctaaag cagaagccgt ttcctgccgt 3036421 cccgcttcat acgacacagg cgcgtcaagc aattcttgtt cagaatgtcc aatcagcttc 3036481 tggttttctg tattctgctg ttctgtatgt gaaggttcag tttgatgttg atcgttttgg 3036541 ccatcacgtc gataatccat gttcttacac tcctttaacg gttattcatt tatcgttaca 3036601 tattcatcgc atgtacaagt tcaattgtcc caataatgag gagaaaagca aagcaccaaa 3036661 atagaatatg tttgatcatc ctacatcttc ctcgctcttt ttctcttcct ttcttccctt 3036721 aaccatatca taaacaaaca ttgtgggata aaaatgaaaa gaatatgtga aattatgaaa 3036781 attgcctgcc gtatgttaaa actagtttat aatgacgttg aaaggatgtg aagagccttg 3036841 tcatacacca tttatctagt tgaagatgag gataacctga atgaactgct gacgaagtat 3036901 ttagagaatg agggctggaa cattacatct tttacgaaag gtgaagacgc cagaaagaaa 3036961 atgacaccgt ctccccacct atggattctc gatatcatgc tgccggatac cgacggctat 3037021 acattaataa aagaaatcaa ggcgaaagat cctgacgtgc cggtcatttt tatttccgcc 3037081 cgagatgcgg atattgacag agtgcttggc ttagagcttg gcagcaatga ctacatttca 3037141 aagccgtttt tgccgcggga gctgattatc cgtgtgcaaa agctgctgca gctcgtatat 3037201 aaggaagctc ctcctgtcca aaaaaatgaa attgccgtct cctcgtatcg ggtcgctgaa 3037261 gacgcccgcg aggtctatga cgaaaacggg aatatcatca atttgacgtc aaaggaattt 3037321 gatctgctgc tattatttat ccatcataaa gggcatccat actctcgtga ggatatcctc 3037381 ctaaaagtgt ggggacatga ctacttcgga acagaccggg tcgttgatga tctcgtccgg 3037441 agactgcgca gaaagatgcc tgaattgaag gtggagacga tttacggttt cggctacagg 3037501 atgatgtcat catgaaaaac aagccgctcg cgtttcagat atgggttgtc atatccggca 3037561 tcctgttagc gatatcgatt ttactgcttg tgttattttc aaacacgctg cgagattttt 3037621 tcactaatga aacgtatacg acgattgaaa atgagcagca tgttctgaca gagtaccgcc 3037681 tgccaggttc gattgaaagg cgctattaca gcgaggaagc gacggcgccg acaactgtcc 3037741 gctccgtaca gcacgtgctc cttcctgaaa atgaagaggc ttcttcagac aaggatttaa 3037801 gcattctgtc atcttcattt atccacaagg tgtacaagct ggctgataag caggaagcta 3037861 aaaagaaacg ttacagcgcc gacgtcaatg gagagaaagt gttttttgtc attaaaaagg 3037921 gactttccgt caatggacaa tcagcgatga tgctctctta cgcgcttgat tcttatcggg 3037981 acgatttggc ctataccttg ttcaaacagc ttctgtttat tatagctgtc gtcattttat 3038041 taagctggat tccggctatt tggcttgcaa agtatttatc aaggcctctt gtatcatttg 3038101 aaaaacacgt caaacggatt tctgaacagg attgggatga cccagtaaaa gtggaccgga 3038161 aagatgaaat cggcaaattg ggccatacca tcgaagagat gcgccaaaag cttgtgcaaa 3038221 aggatgaaac agaaagaact ctattgcaaa atatctctca tgatttaaaa acgccggtca 3038281 tggtcatcag aggctataca caatcaatta aagacgggat ttttcctaaa ggagaccttg 3038341 aaaacactgt agatgttatt gaatgcgaag ctcttaagct ggagaaaaaa ataaaggatt 3038401 tattatattt aacgaagctg gattatttag cgaagcaaaa agtgcagcac gacatgttca 3038461 gtattgtgga agtgacagaa gaagtcatcg aacgattgaa gtgggcgcgg aaagaactat 3038521 cgtgggaaat tgatgtagaa gaggatattt tgatgccggg cgatccggag caatggaaca 3038581 aactcctcga aaacattttg gaaaatcaaa tccgctatgc tgagacaaaa atagaaatca 3038641 gcatgaaaca agatgatcga aatatcgtga tcaccattaa aaatgacggt ccgcatattg 3038701 aagatgagat gctctccagc ctctatgagc cttttaataa agggaagaaa ggcgaattcg 3038761 gcattggtct aagcatcgta aaacgaattt taactcttca taaggcatct atctcaattg 3038821 aaaatgacaa aacgggtgta acataccgca tagcagtgcc aaaatagact gtagatgttt 3038881 tgcagtctat ttttttatgt gaaagaatag ccgttaaaat ctctgtaatt tgttttgagc 3038941 ggctgtttgc attgatgaac ccattttttc tctgacaagg tctgcttcgg atatttgact 3039001 ttctccactt tgattcctct gtttcgcaag cggctgatca tttcgtccaa ttctctcatt 3039061 ctagattcac cctttcgctt gagctttgac cattcggtca tctcaattta taatataaat 3039121 aatacatgat aaaaaaacaa gttacaataa ggttaatttt ataacagacg gtgtgactat 3039181 atggtcatat cctagcaggc ctccgggctc cgaaagggtg gaaccattga aggaaaaaga 3039241 aaaactgatt attgaaacag ccttaaaact atttgcccaa aaaggataca actcaacatc 3039301 agtccaggaa atcgcaaaag aatgcaaaat atctaaaggc gctttttata tttattttcc 3039361 ttcgaaagaa gcgcttcttc tctctatgct gaactactat tatgataaaa cgtttacccg 3039421 aattttaaat attaaaacga agggcgacag ccccagaacg gcttaccgta aacagctgac 3039481 cgtcctctat gaaaacattc ttgaacacaa agattttatc agcatgcagt tgaaggaggg 3039541 ttctctgcct tacacagaag aagtggagca atgcgcaaaa aaaatccgcc agtcctcact 3039601 tcaatttcat atcgacagcc tgctgaacat ctatggaaaa aaagcggaac cgtacactgc 3039661 tgagctttgt tttttaatag agggcatcag ccagatttac ctggaatgca tgattttgct 3039721 cgggtacact gtgaagccgt ctcaattagc tgatatcatt atgaatcgaa ttgatgatat 3039781 ggtaaaaggc atgtctgaac gaaacgataa gcctttcatc acattggaag aggcgagctc 3039841 tttattcgga cctcttacgc acggacggcc tgacccgctg actgaatcaa ttgtgaaaag 3039901 cctacgtgac aaaattaaca gcttaaacac aaactcctct cttgaattat cggagagctt 3039961 ggacatactt gaagcagaaa tgaagaaaaa aacaccgaag ctggcgatca taaaaggaat 3040021 gattcataat ctgacggagt ctgaagctct cgccaaagat gcggaacagc ttaaatattt 3040081 attaaaacag caacatattt agaagaacgg ctgcttaaaa agcagccgtt cttcctatta 3040141 cgcctttggt tttaccatgt cttccggctt aaccatttcg ttaaattgct cctctgtcag 3040201 caattcaagc ttcaaagctg cttctttgag cgtcaatccc tctttatggg caagcttggc 3040261 gattttcgcc gcgttttcat aaccgatatg cgggttcagc gccgtaacaa gcattaatga 3040321 atttgacagg ttttcctgaa tggtttcttt attaggctca ataccgacag cacatttatc 3040381 atggaatgaa ttcatgccgt cactgagcag ctgcacagat tgcaggaagt tgtaaataat 3040441 aacaggctta aacacgttca gttcaaagtt cccctgactc gccgcaaagc cgattgtcgc 3040501 atcgttcccc atgatttgcg ctgcgatcat tgttaacgct tcgctttgtg tcggattgac 3040561 tttaccaggc ataatagagc ttcccggctc attttcagga atgacgatct ccccgatgcc 3040621 gcagcggggt ccgcttgcga gccatctgac atcgttcgcg attttcatta agtcagccgc 3040681 aagcgctttt aatgcgccat gcgcataagt gatttcgtca tggcttgtca gcgcgtggaa 3040741 tttattcggc gagctgctga acgtttggcc ggtcagctta gtgatctctt ctgagacaag 3040801 ctctccaaac tctgggtggg cgttgatacc cgttccgaca gccgttccac caattgcaag 3040861 cgcacgcatt ttatctgtcg cttccaaaat catttccttc gaacggtcca gcatgtgaac 3040921 ccatccgctg atttcctgtc cgagggtcag tggcgtagca tcctgaagat gcgtgcgtcc 3040981 gattttgaca atatcattgt atgcttttgc tttttcatcc agtgtattgc gaagctgatc 3041041 aagcgccggc acaagctgct cgtaaacagc caaaacagcg gcaacatgca tcgcagtcgg 3041101 gaatgtgtcg tttgagcttt ggcttcggtt cacgtcatca tttggatgaa tcgtttgatc 3041161 agagttcttc tcttttaata aagcagtcgc acggttggct accacttcgt tcatgttcat 3041221 attgctttgt gtgccgcttc cggtctgcca tacgacaagc gggaagttgt catcgtactt 3041281 gcctttgagc acatcatcac aaaccgctgc aatcgcttct gctttttcag cgtccagatt 3041341 gccgaggcgt ttattagcta gagcagtgct tcgttttaaa attgcaaacg ccttcacaac 3041401 acgcatcggc attttttcag aaccgatctt aaagttctcc ttgcttcgct gtgtttgggc 3041461 gccccaaaat ttatcagcag gaacttttac ttctcccatg gtgtctcgtt caattctgta 3041521 ttccatttat gtatccctcc ataacggttg cttcaataga tcataattcg ccaatgacac 3041581 aaaaaatcct ttttattttt cgatcttggc agattttaat tttaattcaa gatatacgcg 3041641 ggaatccttt gaatatttgt attttggatt tgtcctgccg tactcctttg atgtataaga 3041701 gacatcataa tgctgttcaa atgatctaat gagctgttca atttcttctt gttttccagc 3041761 tagccttacc tgtgccactt cgtatcctcc gctttcataa aaaaacttac tccatgaaat 3041821 actctaacac agtatatcat ttttttaaca ggaaaagata acctctacta aggttttgga 3041881 taagaggtga cctcattgga acaaacagag tttaaggaat atatacacga taatttagca 3041941 ttggtgctgc caaaattaaa agaaaacgat gatctggtga aaaacaaaaa aatgcttgcg 3042001 aacggactgg ttttttacta tctctatttc agtgaaatga ctgatgagaa taaggtgtca 3042061 gaagccatta aaactttgat taaagatgag gagaccttaa cgcttgacca ggtcaaaaaa 3042121 cgccttgacc agcttgacgc aagacctgtt gaaactgcaa aaaaaacgat tgaatcgatt 3042181 ctcaacggca attgtgctgt gtttatcaac ggattggata aagcctatat tctgaccaca 3042241 ggaaagaaaa aaacaagaag cctgacagag ccgacaactg aaaaagtggt tcgcggccca 3042301 aaagtagcgt ttgtagagga tattgataca aatctcgctc tgatcagaca aagaacctct 3042361 catccgaaat tgatcaccaa aaaaatcatg atcggcgaaa acaagctgaa gcctgcagcc 3042421 attatgtaca ttgaaggcaa agcaaaaaag tccgtcataa aagaagtgaa ggcgcggctt 3042481 aaaaatatcc agctggaaga tatccaggac agcggaacgc tcgaggagct cattgaagat 3042541 aataaatatt caccatttcc gcagatacaa aatacggaaa gacctgacaa agtatcttca 3042601 gccctgttta acggccgtgt ggcaattttg gtcgacagtt caccatttgt gctgctggtg 3042661 ccggtttctc tcggcatcct gatgcaatcc ccggatgact actatgaacg ctggatttca 3042721 gcatctctta tccggtcgct gcgctttgct tctatcttta tcaccttgtt tttgtcatcg 3042781 atttatataa cacttgtttc cttccatcag gggctgctgc cgaccgcact cgccgtcacg 3042841 atttcggcga acagggaaaa cgtgccgttc cctccgatat ttgaagccct gctgatggaa 3042901 gtcaccatcg agctgctaag ggaagccgga ctgcgactcc ccaatccgct cggacagacg 3042961 atcggcctcg ttgggggcgt agtcatcgga caggctgctg tagaagcgaa tctcgtcagt 3043021 tcgattttgg tcattgtcgt cagtgtcatt gccctggcat cctttaccgt tcctcaatac 3043081 ggaatgggtc tgtctttccg ggtgctgcgt tttatttcga tgttttccgc cgctatttta 3043141 gggctatacg gcattatttt atttatgctt gtcgtttata cgcacttaac gagacaaacg 3043201 agctttgggt ctccgtattt ttcgccaaac ggattcttta gcctgaaaaa tacggatgac 3043261 tccattatcc gtctcccaat taaaaacaaa ccaaaagagg tgaataatcc aaatgagcca 3043321 aaaacagact ccactgaaac ttaatacctt tcaaggtatt tctattgttg caaatacaat 3043381 gcttggggcc ggacttttaa cattgccgcg agcgctgacc actaaggcta atacgcctga 3043441 cggctggatc acgctgatat tagaaggttt catttttatt ttcttcattt atttaaacac 3043501 gctcattcag aaaaaacatc aatacccttc actctttgaa tatttgaagg aagggcttgg 3043561 gaaatggatc ggcagcatca tcggcctttt gatctgcggc tatttcctcg gcgtagccag 3043621 cttcgagaca cgggcaatgg ctgaaatggt gaagtttttc ctgctggaga gaaccccaat 3043681 tcaagtcatt attttaacgt ttatttgctg cggcatttat ttaatggttg ggggcttaag 3043741 cgatgtgtcg cggctgtttc ccttttattt aacggtaacc attattattt tgctgattgt 3043801 gttcgggatc agttttaaaa tttttgatat caataatttg cgtcctgttt taggcgaagg 3043861 ccttggaccc attgcaaact cccttaccgt cgtttccatc tcttttttag gaatggaagt 3043921 gatgctgttt cttcctgaac atatgaagaa aaagaaatac acgttcagat atgcgtctct 3043981 aggatttctg attccgatta tcttatatat ccttacgtat attatcgttg tcggagcttt 3044041 gaccgctccc gaggtgaaaa cgctgatttg gccgactatt tctctctttc agtcctttga 3044101 gcttaaaggc atatttattg aacggtttga atccttttta ctggtggtct ggattatcca 3044161 gtttttcacc acatttgtca tttacggata ctttgccgct aacgggctaa agaagacatt 3044221 tggattatcg actaaaacaa gcatggtgat tatcggcata acggtctttt atttttctct 3044281 ctggccggat gacgccaatc aagtcatgat gtatagcgat tatcttggct atatttttgt 3044341 ctccctgttt ctgcttccgt tcattctctt tttcattgta gctctcaaga ggaggattac 3044401 aacaaaatga aaatccggat tttatgtatg tttatatgca ccctattgct gtccggatgc 3044461 tgggacagtg agaatatcga ggaattaagc ttagtgatcg gaatagggct agacaagcct 3044521 gacgatgaaa atttagagct gacacagcaa attctcgtgc cgaaaataat cagcgccaag 3044581 gagggctctt catctgatcc gacacagctt tctatcacaa agggtaaaac tgtccatcaa 3044641 atgatgagaa cctctgcatt aaagcataag cctacgtttt cacagcattt gcgtctcatt 3044701 ctgctttcca aaagcgtgat tgcggatcaa attggaatgg acgccattat taaccagttt 3044761 gtcagagaca acggaacaag gaggagttcc tacgtcttta tcaccaacgg ccgaactaag 3044821 gatatattta acatgaatga tgaaggcgaa cccgcatcca acgtgatata tgatctgaca 3044881 gagaataata aggtgacgat cagaacgatg gagccagtta cattggggga gatctcagaa 3044941 cacttaacct ctgacgattc attcctcatc cctcatgtcg gtaaggaaaa cggcaagctc 3045001 gcgataaacg gagcctctat cataaaaaat aaattatggc accgggacct caccccgatt 3045061 gaggttcaaa atatcagctt attttcaggc actgtcgagg gaggcgtcat tgacttgaag 3045121 cgcgatggcc atctcttttc ttatgaagta tattcaagca atcggaagat caagacggca 3045181 tacaaggacg gaaagttcaa attcaccgtt acccgcaata ttgaaggtcg tctatctgag 3045241 gactggaatc ccaatgaaga ctcgtttaag gattcatata ttaaaagtat tgaaaagaca 3045301 gtcgaaaaac gagtacacga aacagtaacg tcatttatta cagagaagct gcagaaagag 3045361 atcaaagcgg acgtaaccgg gctgggaaac gaggtcagaa ttcattatcc tcaaaagtgg 3045421 aaaaagattt caagaaaatg ggatgatgat tatttcagca atgcggaaat agactaccgg 3045481 gtcaatgtga ttgtcagaga cttcggaacg aaaggcgcaa acaaatagca gccgcctaat 3045541 tcacgagatg atttcggtgt gcgtacaccg ccgcctgcgt ccggtcactg acatccagct 3045601 ttgataaaat attcgtaata tgtgttttga ctgttttaat cgtaataaac agttcctcgc 3045661 ctatttcttt gtttgtcttt ccttctgcga tcaggcagag tatttcgagc tcccgttttg 3045721 taagcgattc atgcgggagc gcgttttcac ctgagtggcg cagcctggat aatacttttc 3045781 ccgccacttt tgactccagc ttcggctctc ccttgcttgc ggcgcggatg gcatcggcga 3045841 tttctgccgc ttttgaggtt ttcaacagat agctgagcgc gccagcttca ataaccgggt 3045901 acactttgtc atcatcaatg aagctagtga gcacaataat tttcgggtcg gaaagctccc 3045961 ggcaaatttg ctttgtagct tcaatgccat ccatgccctc catgacaagg tccattaaaa 3046021 tgacatcagg cgacagttcc acagcaagcc gaacaccttc gctgccgtcc gatgcttcgc 3046081 cgatgacttc aatatcgggc tgcgcctcca aaaaagccgc gagccccatt ctgaccattt 3046141 catgatcatc aatcaataat actcgaatca cgttcgttct ctcctttttc ttccggaaaa 3046201 atcgggacct tcacttcgat ttgagtgcct tttccttcta ctgaaatcac ttcggcgaca 3046261 ccgccgattt cacttgcacg ttctttcata gaattcaagc cgtatgagga ggctttcacc 3046321 tggtccattt taaagccttt tccattatca atcaccttca gacggagctg gctgttcttt 3046381 atgcccagaa tcacggttac ttttgacgct tttgaatgtc taaatacgtt tgaaagggcc 3046441 tcctgcacga ttctgaacaa gtggtcttca acacccttgg atatcgctgt gtcctgtata 3046501 tcccactcaa tatcaatcgg ctgctttttt cggaactcgt ccaaaagctc cgtaaggccc 3046561 tccttcagcc cttttccttc aagggtaaca ggccgtaaat ggagcagcag cgccctcatc 3046621 tcattttggg cttcgcctgc catatgctcg accatcctga tccgcttgac tgttttgtca 3046681 tcagcatcct tgacatgttc cagcacggct gatgtcatca tcgatatggc aaagagctgc 3046741 tggctgaccg catcatgaag atctctggcc aatcgctggc gttcttctga gataaccgac 3046801 ttcttcattt gagcctgcca ttccgcacgt tcattggaaa gtttctggag ggatgcgact 3046861 tgaagctcca cgcgcttcgc catttcgttc agctgatcag cagccaggcc gatttcatca 3046921 tcaccgagcg gcggtatccg ataagcgaaa ttgccgtttt caaaggttaa aatggattca 3046981 attaatgtat caatccttgt cttcaaccgg ttgccgtaca tataccctga ggcgaaaccg 3047041 acggtcacgc tgatcagaag caaaatcagg ataaacggaa ttccgaacca gcttgatgac 3047101 agcaaaacaa gcggatcgag ccgatagtaa aacatcataa aggaaatcag gcaaacaaaa 3047161 aggagcaggc tgattcccgt tgtcatgcgg atggcgcgcc attggaggct ggcaagcatt 3047221 ttttttctca tacgtacttc acatccacat caccgataaa taaggaaacg gacactttta 3047281 cccggcgctt tgactcgcta aaatcagttg acgcggcata taccttcgtg cttaatccgc 3047341 ttttcttcga gccgatcaga ttaatgtctc ctataaaaac agccgagctg acagccactt 3047401 caaggtccga tggtacataa atatcaacgt taccaatgac tccgctaatg acgattgtac 3047461 tttctccctc gggaatcatc gctttagata aatcgatttt gatatcaccg ataaaaccag 3047521 agacatttaa atcgttcagg tcaaacggct gcttcatcat ttgcagctca ccgataaaaa 3047581 agctgcgcat gtcgggatgt tttacatctt ttggcggctc atgatgttct tttttattga 3047641 gattgacctg tttctcattc ggttcaaata tcggcttccc tttgataagc ctgtagccgg 3047701 cgtaaatcag aaatgcggca aacgcatagc cgaataaatt aaaggtgatg ctgaagaggt 3047761 ttttcaaaaa tagaaacgcg gcaaagatat acatgacgga gccaagccaa tcacgggaat 3047821 attttttaag gaaatagccg gcaatcagaa aaaagagcgg ccaaaacagc agatcgccta 3047881 ttccgataat ttgcaaaaac atactgatgc cgaataaagc aatgatcaat ccgagaagct 3047941 gtttttttgt cattcctggt gtccgcctcc tttcttctgc ctagtgctac cgtatcgcta 3048001 gatccccgct gtccgttttg atgtcgattg gatgccggcc gcttccttgc gtgcctgtga 3048061 tgtgatgctg ttctttatgt cctttatcag caaatgaata cggcgaactg acgtcaccgc 3048121 ttgctgataa agcattgact gcaaagctgc cattttgggg aaggcttaca ttagcatcac 3048181 cgcttgtcag cgtgacagat acgggaccgg ttaccttttt caatacagca ttaaaatctc 3048241 ctgaagtcat tttcacatca agagagcctg atacatgaac cagatttgcg tcccctgaag 3048301 ctaaatcaat gccggctgtt ttggagacgg tatttgaaat ggaaacatcc cccgatgatg 3048361 ccttcacttt cagatcttga atgcggacgt ccgtcacgct cgtatttccg ctcgcagata 3048421 ctgcgttcag cccggaaagc gcaagatggt cattcccggc cacagacacg tcaccgcttg 3048481 aggttcgtac tgccagatca cctttataat catacggaag cctgacgata agagttgaac 3048541 ggttaaatcc attcaaaaat tgaaattctt tttcctttac ggtcagctcc agttttcttt 3048601 tgttttcagt aacaaataac tttcctgagt ctcctgaaat gcctgccgat atgtcacttc 3048661 gttcttccgc tataatccgg acatccttgc tatccgactc aatgaccatg ctgtcaatgt 3048721 cccgcggcga tgcgctggct gaatcagctt ctgtgccatt tatgaaacct aggcctgcag 3048781 caaacacatc ttttacgacg acggcgaaaa aaaccagaat accggcagtg atcaacagtt 3048841 tgccaagcat ttttttcatt cggtttcatc cttctcattc attctattat aaaggaaaag 3048901 cttgcgaatt gatacgtgcg gaagggaagg acttgaccgc aaatccttcc ccgttccgct 3048961 tattcatttg ccgcttttgt ctggtctgat ttttgcagtg aaagtgtccg cattttttca 3049021 atctccgctt ccacatcgtc tgcgaattct ttacgtgtaa gttctgtgcc ggcttccgct 3049081 gactttgaat aattcgcgcg gatttccatt tcttcaatac gattttcaat acgtaaaaat 3049141 tcacgatacg cgctttcact gtcaattttg tcaaatgtcg tattcatatg ctctttagct 3049201 ttcgccgcat ttgcccgcgc aatcagcgcc tgttttttat cctttacgtc ctgaagcttt 3049261 gtttcaagtg cagccagctg ctctttcaga tcagccagct gactgtttgc ctgttcatag 3049321 gaagctttat gctcagccgc cttcccttct aaatacttca tttcagtcag cgcctttttc 3049381 gccagttctt cttcacctgc gtcaaatgcg agctgtgcct gatttttccg tttgccagcc 3049441 acttcagcgg cttcttcata ttttttctta aattgatagg caatcgtgtg ctgtttcaca 3049501 attgtttgct ttgcttttgc gatgtcgctt tccatatcgc gtacatattg attcagcatc 3049561 acctttggat tctccatttt atcaagtcct tcatgaactg acgcaacaaa catgtctctg 3049621 attcttttta ataccatacc tgattcctcc taatatattg atattatttt ttcttcaaaa 3049681 attcttccca ttcgtcatca aagtgagatt ggtaggcagc agaagccggt tcaggatcaa 3049741 aagatgatac accgttatca gctgatccgt ttttcatcag cttccagccg taatacacca 3049801 tagcggccgc caatgcgatt ccgacgacaa acggaagtga gcagatgagc ataatggctc 3049861 cgataccgcc cacgatgatt cccgtgatgg tttttcccgc ggcaaacctt ttgattcctg 3049921 cgtatgtcat caagctcccg atggcgagcg ggatgataaa gccgaagctt cctcctccaa 3049981 aaaagacgga gatcccaaat acaattaata agaatccgcc tattgttttc ttgtttattt 3050041 tcatgcagat cctcctttcg ttttccttgt cttcatctta tacaagttgg aagatatgca 3050101 aaacgaatca gagattgatt tttatataag accggagtcg tatctcgcac cggacccatt 3050161 ggcacaaaaa aacgccatgc acgaggcatg gcgttttaaa accctttaca gatgaacact 3050221 tgcttccctt tctttaatta ggtcggacct ttctgctttg gccaattttg taaacagcaa 3050281 gattccgata cccgcaataa tttcgacaat cccaccgaca gcgatcactt tacctgagcc 3050341 gaaagcatta gcggcatacc cgcaaatgac agctccggca gggatcgaaa tatttgagat 3050401 catatgtata acggcgtaaa cctgcggctg atcctcacta tccacagacg tctggataat 3050461 cgtgtactca ggaacattaa cagcactgac tgcggcacca aaggtaaaag cagcgaaaaa 3050521 gacgagcggc aaaaaggtat tcatcccggt aataaagaaa gcaaatcctt caataatgcc 3050581 ggcagtgacg aataacaagc cgtacctgtt taccttgact ttcgccagca caaaccctaa 3050641 taaaaacgcg cccgcggcgg tggtggcctt taaaagcgag tatacgatcg gctggccgtt 3050701 taaatcttcc gcaacgtata cggcagagag cgcttcccat ggggcagccg cgaaattcat 3050761 aaagatacag taaatggcga gcggatataa aatctggtgt tttctgacga gcctaaagcc 3050821 gcgtttcagt cttccgatat atgtgcctct ctgtgtaaca accgcagact ctgattgaga 3050881 ttcaaccgca gtgtacttaa taaaaagaac gagaaaacct gacaccaaat agagcacaag 3050941 tgcgataagc atggtataag aaggactaat aaatgtaaga aaagcgccgc ataatgtgac 3051001 agccccaagc cggacaattt gagcggagga ttgcagcaca gcgtttgctt tttgaatgcc 3051061 ctgttcattg acgatttgag gaatcaaagc gatagaggcg ggattgtagg cagctccagt 3051121 agctgaatgc acaatcataa gcgtcatgac aaaccacagc ggagagaagc ccgcaaaatg 3051181 acatagaggg ataatcaaaa caatcgccgc ccttgtcaga tctgaaaagt acatccaaaa 3051241 tttcagcgtg gtctgtttca taaaaggccc cgtcacaggc gccagaacgg cttccggcaa 3051301 aaacgtgaca gcaatcaata aagcagtgcc gatcgcacct ttgccgtcat aaattaaaaa 3051361 ccataatatt gaattaaatg cgaacatatc gccggatatc ttgactattc ttgagaaaaa 3051421 cagataattg aaatttctct tccagatgct atcactttca attaaattca ccatccatca 3051481 gagccccccg ttgcctattt tttacatcta tttattacaa tatctcattt ttccattttt 3051541 cagtcaataa ttcataaggt tcattttttg tcgtaaaatg ggaaattgac agagtgaaaa 3051601 acaaaaaaag ccggcatgta tttgaacacg ccggctttcc ttttcacttt ttatgattcg 3051661 ctgctgtttc ggtcccgaaa cacaatggca cttctttcat attctacatc gccaataccg 3051721 cttcttgcat tcacaacccg ggcggcggca aagaaataat cggacagacg attgagataa 3051781 cgcagcactg tttcatgaat ctcctccgat ttcatcagcg ccaccactct tcgttctgcc 3051841 cgccttgtaa tggtgcgtgc gatatggaga agcgaagcac actttgatcc gcctggaaga 3051901 ataaatttct tcagttccgg cgcttctgct gtataggcat caatgcgcgt ttctaaaaag 3051961 gaaacagatt cttccgttag tttatagtct tttctttctg tgacgattgc cagatcgcct 3052021 ccgcagtcaa acagctcatg ctggatggtc agcagctcgg ctgtcagatc ttcaaagccg 3052081 ggctgcccgg aaagctctgc caaagcaagc ccgataaagc tgttaagctc gtcaatcgtg 3052141 ccgtagcttt cgacgcgtag gctgtccttg tccgttctgc ccccgactaa gcccgtttgt 3052201 cccttatcgc ctgtttttgt atatagtttc ataccctgaa tctcctttac agacttattc 3052261 aaacaactca gcagcctctt ttatacattc agctgtccct ttctttatca attggttcag 3052321 ccgctgttct atgttttctg attgctgagt ttgagtcgcg gcgatgagaa tatcacctgt 3052381 gcctcctccg tctcccagca ctttcgtccg ttctgcttcg gcagccataa gagctttgat 3052441 gaagaattga tctgccgcat agccgttaat caaaatccaa atcgaaaagc cggtctgaac 3052501 gcatatgaaa acggataact ctccgtcttc atatgttcga tacacgaaac ggtcaagtct 3052561 ttctgaagaa gccatcgcac acgtctcctg cagttgaaaa ccgctttctg aaagacaggc 3052621 cgtaagtcct tctatcggat ctggctgatc tggcagccgt ttatggatca gcgtcctgct 3052681 ccacgaaaac cctgcaccga taggcgtgga ggacaatgtt cgaagcggga tttccgtttg 3052741 cagaagaatg tcatcacgcc ccgcttggag caatgcttca aatgggatag actgccgctt 3052801 cacgctatct ttttcaggct gaatcacaat catcggttta ggtgagcttt gatgaaccaa 3052861 ggcggtgaca tctgtatcgt acaccgcctt tatgctttgt tctgtaacag catattccgg 3052921 tttttgctta ggcccggcgg taccgttttt cataaacatg agcccatcac agtacaggct 3052981 tgcggtgttc agatcatgaa aaacgctgac agctgccaat ccgctttctc tcgtcaggcg 3053041 tttgatcaga tcaagcaggt ctttttgata agccagatcg agaaaattag tcggctcgtc 3053101 caaaaataaa atacgcggct gctgcgccaa agcttgtgcc aaatacaccc gctgctgttc 3053161 ccctccgctt agttcgcgaa tcggcttttg cgcaaaatcg gccactcctg tttgctccat 3053221 tgcttcctgt acaatggctt cacccttttc agtctgctgt ctgaacagcc ccgtttggaa 3053281 tggatatctg ccaaaggcta cagtttcttc gacagtaaag gtgaaggctt gatccatttt 3053341 ttgcggcagg acagccatga tttgcgccag ttccttcggt ttatagtccg ccagcagttt 3053401 tccggccaga taaaccctgc ctttcttggc cggcagcgta cctgtcagca agtgcaaaag 3053461 cgtggttttt ccgcttccat tagggccgag aattccaaga aattctccct tctccactgt 3053521 taagctgaca ttgttgatta ggcggctgtc gccgtatcct cccgacagcc cttctgcctt 3053581 catcataagc ttctcccccc gcgatgctgc cgaattaaaa taagagcgaa cacaggcgct 3053641 cccgccaagg acgtaatgat cccgatcggc agttcaatcg gctcaatgat ggttctggaa 3053701 agcagatcgg ctaaaacaag aaaccctgcc ccaagcaagg cggacaacgg cagtaaatgc 3053761 cgatggtccg ttccccacaa aagccttgtg atatgcggaa tcacaaggcc gacaaagcca 3053821 atcgtacccg atactgccac agcgcttccc gtcaaaagag atccggctat taaaatcatc 3053881 atcttcctct gctgaacgct gactccaaga agctttgctt tatcttctcc atatgtcatc 3053941 acgttcagtt cccttccgtt tataatcaat aaaatggttc ccaaaagaaa aaacgggaga 3054001 aacaaaataa catagctcca gcccctcatt gagacgctgc caagcagcca atgcacaatc 3054061 ggaagcaggt tgtctcctgt caaggcgatg ataagagaaa taaatgcgcc taaaaaagag 3054121 ttggtgatga caccggtcaa aatgagggtg gaaacagaca tcgaagcatg aacgaggcgg 3054181 ctgaagaaaa ggaccgccgc catcgtggcc agtgccgcgg ctacactcaa aaccgggagt 3054241 gtaaaccctc cgatgacagg aaggtgcaaa cctaagaaca gagtcacaac agctccgact 3054301 gaagcaccgg atgacacacc tagcgtatag ggatcagcaa gcggattttt caacaatcct 3054361 tgaaaagcgg cccctgcaat agaaagagcc gcccccacaa gggcggccag cacaactctc 3054421 ggcagtctga tattcatcat aatattagtg tacatcggat catcagaacc gatagagccg 3054481 ccgaaacctt gatgccaaaa gacacgaaaa acagcgggaa taggaatatg caggctgccg 3054541 caagaaattc ctaagatgat gctcacggct aaaaatgaga aaccaatgat atatgcggca 3054601 taacgattat tccttaaacg tatccgggta aatgctttcc gcaagttctt cgaccccttc 3054661 gatcagacgg ggaccggaac gtgtcacaag atcagggtcc acatcatata cacgatgatg 3054721 tttcacagca ttgatttcgc tccagccatc gcgtttttcc acagctttcg ctttcacacc 3054781 gtccgttgta acaattgcat caggattgag ttttacgatc gcctcgtctg tcatttgcac 3054841 ccatcctgtc tgatccgcag ctgcgttttt agcatggatg acatttagca tttcattcat 3054901 aaacgtatct tttccggttg tataaatgtc aggatcagga gaaacctcga taaatacgct 3054961 tttctcctcg tcttttgaaa tggttttcgc tttttcttga atatccttta gatctgattt 3055021 catgcttttc acgagctgat cggctttttt ctccgccccg ccagcttctc cgatcatttc 3055081 gattgatttg tacacctcgg agaatgattg tgcatcattg acagtcagca ctgtaatgcc 3055141 cgcgtccttc agctgtttga tggcatccgc tgatgctgac atggaagact catgggccag 3055201 aacgagatct ggttttagag aaatgacttt ttcaacgttt acattcatat ctccgacttt 3055261 ctcaaccttt ttgacttcct ttggataggt atcgtttgtg gtgacaccga ccactttgtc 3055321 accaaggccg agtgcgtatg taatttctgt gttgctcggc attaatgaaa caatcttttt 3055381 tggctctttt ttgatggtta catcttggtt tgacgcatca tcaatggtga cagggaacac 3055441 ttctgttttt tgttttgcct ttgaatcctt ctgatccgca ggattgccgc agcctgccag 3055501 cataacagca gccaacagaa gcgcagccca tatcccggct cgttttttca taatcttttc 3055561 ctcctaaacg aactaaaaaa gcatctctac gacggtaaag atgctgtaaa caacacaaaa 3055621 aagcctattg tttacacatc atctgtcctc gcagaattcg tgctgatcaa acaggcaggt 3055681 atcctggctc ttggcgcttg gccaattaca gtggcgggac cgcaccggct tttaccggtt 3055741 tcccttttaa gccggctgtt gttcacggac cggcacctat ttgacattcg tatccgtttt 3055801 tcggagtaat tatactatat gactgacagg cttgtatatg tgtcctgaat gacttttccc 3055861 catattgtgt atggaagcaa aatcctcgta aacactaaat ttgatcttgt atacttaata 3055921 ccatcatcta tcaaaaggaa tgattcttat ggatttacag ctaaaagaaa aactcgtctt 3055981 aatcaccggc tcgacgtccg gtatcgggaa agccgccgca aaaagctttc tgcaagaggg 3056041 tgcggcagtc attgtcaacg gacgcaaaca ggagactgtc gatcgcacca ttgaagagct 3056101 ttctggctat ggaacagtgc acggtgctgc tgccgatttg tcaaaaacag atgaagcagc 3056161 ggcttttatc gaaaaagtaa atgaaatcgg tgatatcgat atccttgtca acaaccttgg 3056221 tttcttcgag gtaaaagact tcgccgatgt gacagatgaa gagtggaatc aatatttcga 3056281 agtgaacgtg atgagcgccg ttcggacaag ccgtcacttc cttccaaaaa tgcttgccaa 3056341 aaacagcggc cgcattttaa atattgcaag tgaagcaggc gtcaaaccgc tgccaacgat 3056401 gattccatac tcaatgacaa aaacggcact gatcagcctt tcaagaggaa tggctgaaat 3056461 gacaaaaggc acaaatgtga cggtcaactc agtgctcccg ggacctactt ggacagaggg 3056521 cgtggcctcc tatatggaag gcgccgcaca agcagccgga caggatacag atacatttat 3056581 caaagactat ttcaaggtca atgagccaac ctcacttatt cagcgatacg cgacagcaga 3056641 agaagtcgcc aacacaatcg tattcctcgc gtctgacgcc gcatccgcca ttaacggcac 3056701 ggcacagcgt gtggaaggcg gcattatccg ttctctgtag tataaaaaaa cgcatccgtg 3056761 tttcggatgc gtttttttta tacgtctcca gcaaatggta ccggctgata tccgcctgtt 3056821 tccagttgtg ctgaaaacaa ccctccagcg tgaggctgct cgtatctctc tttttctgtc 3056881 atttgttctg ttgccgttgt aatgtaaagg gtttttaagt ctctgccgcc gaacgcgcag 3056941 cacgtgacat atttagccgg cacgctgatt gaattgattt cttttttctg aaacgggtca 3057001 atgtgaacaa cgcggctgcc gccaaacagc gccacccaca gcatgccatt ttggtcaatt 3057061 gtcatgccgt ccggcaatcc gtctgactga tcaaaacgat agacaggttc tggattcgaa 3057121 acatctccgc tttgaggatc atagctgtaa cgtacaatct cctgggtcgg cgtgtcgatg 3057181 taatacatca aattccgctc gcggtcccaa tccaaaccgt ttgaggtgga gacttgatcc 3057241 ttgattttga caagactgcc gtctagattc aaacggtaca gcgacgcctg tttttgctcg 3057301 ccttccatgc tcgtcgtccc cgcccaaagc cttccgtacg ggtcacattt agcatcatta 3057361 aatctcaggc tctcatgcat gtccttcggc tgtttaattt tttccaagct gtcatcccga 3057421 agatgataca ggtaaaaccc gtccttcatc gtcataatca gttcatcctt tgaatatttc 3057481 gcaagcgccg tcacaaagga tttgaatttg attgatcggt tgattttttc ttcagggtca 3057541 aagatgtgga gctcgctccc caggatatca acccaatata agcggccgtt ctcttcatcc 3057601 cataacgggc cttcaccaat cactgcccga gtgtctgctt ccaatactgc atccatgtgt 3057661 tacacctctt tagcttcagt ctatatattg ttattcccgg caaagaggtg tccaaaccac 3057721 ttgatgttta ttgtttttta aaaaggatgg taatgaccgt tccaatgttc gttctgctgt 3057781 tcacatggat cgttccgtta tgcagatgga caagctcctt ggcaatcgcg agcccgagac 3057841 ccgttccggc agttgaatct tttgtgttcg tccctctgta gtagcggtta aacaaatggg 3057901 tgatcgtttc ttcatccatt cctttcccat tgtccttcac ttttaaagaa atatgatttt 3057961 ttgtttgctc cagaatgact tgaatctctg ttcctttgcc gttgtgcttc acggcattcc 3058021 caaggaggtt ttctaatatg cgcctgaacc acgcttcatc aagggcaaat tcaatatgct 3058081 cttctttgga tacaaacgag atatcatagc cttcagaaaa cggatttttc ttaaaatcct 3058141 caatgacatt tttaaaaaac gggataaggc tagtgagctt tctctcaata ggaagagcat 3058201 catttttcag gcgatacgtt aaatttaagt cttcaatcag cttagacatg tattcagatt 3058261 tttctctgac aacctgcccc atttctttca cttcttccgg cgaccagtca tactgcttcg 3058321 actcgagcat catgctgtag ccgtaaatgc tgctgagcgg tgtttttaag tcatgtgaca 3058381 aaccggcaat ccattcttcc cttgtcgcct ggattttttc tctgtttctt ttatcccttc 3058441 tcagcgtttc agtcagctga tccattgatt caaatatctc accgaagaag cggtacggct 3058501 gtttgatttt tcccttttta tttttgctga caggacggcc ttcccggttt ctgggctcct 3058561 caagcttccc ttttgacaga ttgaccagcc atctaatcgt gtgaaaaatc ggcagcccga 3058621 atcggaacat ataccaaacg gtcatccaaa tgatatacat gaacaaaacg gccatcacga 3058681 gaaacatcgc ttttaataca accttcagga atgatttgtt aaactcctga tcggttacat 3058741 agactgggtt cggcaccgta gcgaccatcc atctgtcttt attgaggatc ttaacggaaa 3058801 tttcccgctt atagttccaa ggcttagagc tgtatttaag cagctccagc tggttcatcg 3058861 tttttctctc gctttttgtg ctgttgatgc tgtcgagaat ctttccattg ctgtctaaca 3058921 ggtaaatggc gccttttttc cgtttaatat agtcgatggt actagactta tagtgcgcta 3058981 gtgagtctat cttttgttca cgcttttcaa cggaagtcag gagctgttca ctttttgatt 3059041 tccagccgga caatagaaga tacgacttat cttcaatatt gatggcccaa taattcagtt 3059101 tatagttatg aagctttttg gttttataaa tagacaaaag ctctttcttg gtataggtgc 3059161 ccggcacgtc ttttggcacg ccgtaggaat aatcagtgtt tccttccgaa tcaatgattt 3059221 gcatccagcc gtgctgttta tcaacagatt tcttcaggaa attatccact tcccatgtcc 3059281 cgtcttcgtt tacatcgaga tatgcctcaa gtgtgtcggt cgttgctttc gtcagccctg 3059341 aattggattc cgcatcgcta aaacgggcgt ctaaatagaa aaacgatgca acaagcataa 3059401 ccgtaagcag caggatcaca atcagcatct ggccgaaaaa gtgaaacaaa aacttccatc 3059461 ttaacctcat gaccgcttgc cttcaggatt tgggataaaa cgatagccga gacctcgaac 3059521 ggttacaata tactccggat tgctcggatc gcgctcaatc ttctccctaa gcttgcgaat 3059581 atgaaccatg acggtgttgt tgtcaccgta ggaaggatag ccccatactt tttcatatat 3059641 ttgatctttg gaaagcacca cgttagggtg ttcacaaaaa tactgcaaaa gctgcagaag 3059701 ctgggctgaa caggcaacgg cttccccgcc tacgatcaac tcggcatttt gcggagaaaa 3059761 agtaaagtaa tcatatgtgt aggtttgatt tgaactcgtt tctttcgatt gatatgtacg 3059821 cttgagatgc gctctgatcc gcgccgctaa ttccagcgga ttaaatggtt ttgtgatata 3059881 gtcatcagct ccaaccgcaa agcccgataa tttgtccgcg tcggatgatc ttgccgtcag 3059941 gaaaaaaatc ggagcgtctg aatactctct gatcaatgtg caggcttcaa aaccggacat 3060001 tccgcccatc atgacatcca gcacaatcaa gtcaacctta ttggccttca caacgggaat 3060061 cgcttcttct gcgcttgccg catccagtat atttcgataa ccttcttttt cgagaacgcg 3060121 tttgatcatg tccacaatcg ctttctcatc gtctacgatt aaaattgacg cattttccac 3060181 ttttatgttc ctttctgtca ctgttttttt catcttatca ttatatcgtt tatttatggt 3060241 acatttttga atacattgga gccttggcaa atcaaaacag caaaaaagga gcaaacaagc 3060301 gctccctttt gatgtttttt catatgaaaa tattatgagt tctcatctac catgtacaaa 3060361 ataaactccc aaaaccccgg tacatcctga cataaaagca tatcagcctt ttcaaacatt 3060421 ttgatcttca gctcttgctc taaatcttct ctttcttgat aggacgtatt gctgagtttt 3060481 tttctgatca tcggtgaaaa gcatgcaatc aggtgctcaa tgtcataagt ctcgtctttt 3060541 tgtttctttt tttgttcaaa ctggccgtcc acagcttact tttccccctt tttttgcgcc 3060601 gctaactgct ttctgatatt ctccagcccc tttttatgaa tgttggagat gttttgtcgg 3060661 gactccccta atgaatctgc aatctcctgc atcgtggcac cgtgaagata gactttcgtc 3060721 agcacacttt tttgtttgtc agtcagcttc tggatcgctt ggtagagctg gtaatcctgt 3060781 acatgctggc tcaaatcatc ctgcctgtct aaaaattctt caaatgcatc gctacctgtt 3060841 tcggaagaaa gccgatctcc cgcctccgga tgatcaaccg tcagtggata ccgtttttgg 3060901 tttttgcgaa cccgcttatc aaaatcaata gaaaagatgc gaatcattga attcatatac 3060961 ttgacgatgc ggatttcttt ataaaattgc ttaaatagct cgtccaatga tcttgcatct 3061021 ttttcgttag ggctttccat tacgtttttg aacaaacggt aatgctgagg attgctcaaa 3061081 aaatgcttca cgatgggatg cttcattatc tccttacatt ttgaccgtaa aagactttga 3061141 tagtccatca aaccgcctcc ctactaaatt aaatgaagga aagcaaaaaa aagtaaacta 3061201 ctactttccg cctagtgtct tccaaaatac tttgcagcag tttacgtttt atcggttttc 3061261 ctcacttaca tacatgactg cagaaaaaga agggaggtat tttcctatgg atcaggtttt 3061321 tatagaggaa gtcgtaaaac agatcggcaa tttggggttt cccgcgctga ttgcaatgta 3061381 tctgctgacc cgattcgaaa agaagtttga tcaactaata gaactaatga cagaactgaa 3061441 agatcatgca aaaaaataat ttttcaatcg aagttgactt ttcactggtt tttttcactt 3061501 aacaaaacag aagggaaaac gaaaggcctt tcaccttctc tttctgctat cacatttaaa 3061561 tgtaaggagg aaacatttca tgaaaaaaca aaatgacatt ccgcagccaa ttagaggaga 3061621 caaaggagca acggtaaaaa tcccgcgcaa tattgaaaga gaccggcaaa accctgatat 3061681 gctcgttccg cctgaaaccg atcatggcac cgtcagcaat atgaagtttt cattctctga 3061741 tactcataac cgattagaaa aaggcggata tgcccgggaa gtgacagtac gtgaattgcc 3061801 gatttcagaa aaccttgcat ccgtaaatat gcggctgaag ccaggcgcga ttcgcgagct 3061861 tcactggcat aaagaagctg aatgggctta tatgatttac ggaagtgcaa gagtcacaat 3061921 tgtagatgaa aaagggcgca gctttattga cgatgtaggt gaaggagacc tttggtactt 3061981 cccgtcaggc ctgccgcact ccatccaagc gctggaggag ggagctgagt tcctgctcgt 3062041 gtttgacgat ggatcattct ctgaaaacag cacgttccag ctgacagatt ggctggccca 3062101 cactccaaaa gaagtcattg ctgcgaactt cggcgtgaca aaagaagaga tttccaattt 3062161 gcctggcaaa gaaaaatata tatttgaaaa ccaacttcct ggcagtttaa aagatgatat 3062221 tgtggaaggg ccgaatggcg aagtgcctta tccatttact taccgccttc ttgaacaaga 3062281 gccgatcgaa tctgagggag gaaaagtata cattgcagat tcgacaaact tcaaagtgtc 3062341 taaaaccatc gcatcagcgc tcgtaacagt agaacccggc gccatgagag aactgcactg 3062401 gcacccgaat acccacgaat ggcaatacta catctccggt aaagctagaa tgaccgtttt 3062461 tgcatctgac ggccatgcca gaacgtttaa ttaccaagcc ggtgatgtcg gatatgtacc 3062521 atttgcaatg ggtcattacg ttgaaaacat cggggatgaa ccgcttgtct ttttagaaat 3062581 cttcaaagac gaccattatg ctgatgtatc tttaaaccaa tggcttgcca tgcttcctga 3062641 aacatttgtt caagcgcacc ttgacttggg caaagacttt actgatgtgc tttcaaaaga 3062701 aaagcaccca gtagtgaaaa agaaatgcag taaataaaag acttgcggct tgcagagagc 3062761 actcgttctc tgcaagcctt cataaggagc tgaaccagtg aaacatcaaa acccttcaaa 3062821 acgcttattg cggctctcca taaagtactt gctggccgca gcagcagtgg tgttgaccta 3062881 ttttgctgtc atctatatat tgttttcttt agcgggaacg agctaccgct cagcagctca 3062941 tgtcctgctt tttgccgtgg tattccttgt tctcggatta tgctttgaac catttgaacg 3063001 gctgatgata catagcttta catttttcaa gacaggaaaa cgtctattca ttctccttgc 3063061 tggcatcgta cagctgctgt ttttgtggat gactgctcat acaacagacc aattgatcag 3063121 cgacatctgg ctgtccacca cagaagaaat gattgtcgca gccgtttttt tgattttaga 3063181 caaatgcaac tcggctcttc ccagctaaaa aaagaacgca ttccaattgg atgcgttctt 3063241 tttattcata gcgaagcgcg tctacaggct gaagcttcga agccttgata gacggaagca 3063301 agccgaagat aatgccgact gccattgaaa agatgagtgc tccgacaaca gctggaatgg 3063361 agacgataaa aggcatcgga aaaatgaccg tcagcagctt ggcgatgccg aagcccgcca 3063421 gcacaccgag tattccgcca atgcttgtca gcacgacagc ctcggttaaa aattgaaata 3063481 aaatcacacg ccgcttagca ccgagcgctt tcttaattcc gatttccctc gtgcgctccg 3063541 ttacggaaac gagcataatg ttcatgacgc cgataccgcc caccaaaagt gaaatactgg 3063601 cgataccgcc aagcagcaat gcaaatgact gattaaagga ctccacttcc tgcgcgatct 3063661 cctgaagatc cattacactg tactctgctt tttccagctc agcttctgac agtccctgat 3063721 ttaaaagatc tgcagccatt acacccgctt cttggatatg ctcagaagaa tcagcctgca 3063781 cggcaatctg cgttggcgcg tcaaatcctt caataagcgg ccacactttt ttcggcacgt 3063841 acaaaaccgg gttcgcatag tcgccttcaa acatgctttc ctgttgattt ttttctttaa 3063901 aaacacccac gaccttaaac ggcacaccat tcatctcaat gcttttatgc agagcttctc 3063961 cgtctggaaa cagttcatct ctgacagctt cattgatcat cactacttgg tgtgtgctgt 3064021 ttaaatcgtt ttccgtcagc tttctccctt cggttattcg gattggaaac atgtcgaagt 3064081 aatcatcgtc cactccatac acttggggat acgaaacgtt agttaaatga aaaacgctcg 3064141 cgccttctga caagtaatat aaggataatc ctttgaccat cggatctgat ttgatcgcct 3064201 ttactgtttc ttccgctaca ggcggcgcgg acgcatacga cacctgaggg ccgccgctct 3064261 cctcttctcc gccagacggc tggtagacaa cattgatggc gttgtttccc atgccgatca 3064321 tactttgctt taactgctca ctttggccct tcagcattga aacaatcgcg atgattgccg 3064381 ctatgccgat aatgacgcca agcattgtca gaatcgatct taatttatga gagaaaatgg 3064441 attgaaagga gattcgaata tgttcaagca tggctgatat cccctctctc atctaatacc 3064501 aactctccgt ctctgataaa aacggttctg tcagcttttt tggcgacgtc cgggtcgtgg 3064561 gttatcataa taatggtctt gccttcccga tgcagttcag aaaacagtgc caaaatttgt 3064621 tcacttgatt tggtatcaag cgccccggtc ggttcatcag ctaaaataaa cctcggctga 3064681 ttgacaaggg ccctcgctat cgccacccgc tgcttttggc cgccggacag cttaggcggt 3064741 ttgtaggaga ccctgtcttt taatccgact ttttccagcg cttcatatgc ccgttgcctt 3064801 ctctcttttt tcttcacttt attgtagatc atcggcagct cgacattttg cagcgcggtg 3064861 agacgcggca gcaaatgaaa agtttgaaac acaaacccga ttgattcatt gcgaatttcg 3064921 gctaaagccc cgtctttccc tttcaatata tcgatctggt caagcgtata ggttcctgag 3064981 gttggcctgt ccaaacagcc gataatattc attaacgttg actttccaga accggaaggc 3065041 cccataatag ctaaaaactc ccccgcctga acggtcagat tgatatgttt caagattgga 3065101 acttcttctt ttcccagctt gtacgacttc gaaatattat tcagtgtcag cattgactgt 3065161 aacctgcttt ccttccttga ccgcgggatc aggatagatc acataatctt ccggcgtcag 3065221 gccgctctta atttccacca tgtcattttc atcagtctct ccgatttcaa caggctgctt 3065281 aaccgctttg tgattctcat cagctttcca tacgtacggt tcgccgtcat cctgaatgac 3065341 catgtcggac ggcagcttga tcgtgtccgc atcagcatta tcactcatca cttcgatgtt 3065401 gacatgatag ccgacttcaa gacctttatg gctgtctaat aaaatggtga aaggatagtt 3065461 agaggactgg ggattcattt cttcatcagc aaagctttct gattcttcac cctcgcctgc 3065521 tcccgctgga agcttgccga tcgaggtgac ctttcctttc cactcgccct caccgcctgt 3065581 tttcagcgtg accctgactt tgctgccttt tttgatcgtg tccattaaca gctcattgat 3065641 ttggcttttg accagatatt tgcctgtcga aacaatctgg atatacgggc ctgctgcctg 3065701 gtcgcctgtt gcaccgtcag cgatatcctg attgacgctt tgaacgattc cgtcatgctt 3065761 gcttgtaatg acattggaac ctttgttttt cgtcaggcca gccagttctt tttgatgctg 3065821 cttcagttca agctggcttg ttttcaaatc gaaattggtt tgatcaagtt catcttgaag 3065881 ctggtttttc tcttcttttc ctgcaacttt cagctttttt tccgtttccg ttattgattt 3065941 ttgcaaacgg ttgatttgca gatttgtcat ttcaatttgc aaattggctt gctccacttc 3066001 atcagaatga tcctcgccct catactcaaa aagcttatcg ccctttttaa cctgatcgcc 3066061 ttctttgacg tatgtttttt taatgctgcc tttttctgaa tctatgtata ctttctgctg 3066121 tttctcaggt tcaacctttc cagaaaacgt ttggcctgat tctgaatctc ctcccatgta 3066181 taccgcgacc gattcagcat agggctccga tgatacggca acttggttca tgtgagtaaa 3066241 aaagtaaaaa ccgccagcgc cgatcccagc caatacaagc acaccggcac atatcgcacc 3066301 gccaataagc cattttttct tcttggacac aacgatctcc tctttctgta aactatgtaa 3066361 tattttcgaa acattctaac caatattatc tattaattca aaaagacttg caatcctttt 3066421 attgaaatga cggaatcaaa tagaaaaatt gtattttcaa agccgaataa aaaaaatccc 3066481 ggcttcaaac cgggattttt tcatacagta actagctctt tttcattttt aatcaagtca 3066541 tatgtcaagc atacaggttt atttgtacgg ggatcagtca cgatttcggc atcaatctga 3066601 aatacctgct tcaaaatgtc tggtgtcatg acctccagag cagttccttc cttgatgacc 3066661 gtgccttttt tgagcgcgat catataatga gaaaaacgag ctgcatggtt aagatcatga 3066721 atgaccatta aaatcgtccg cccttgctct ttgttgagtc tgtcaagcag ctgcagaatt 3066781 tcaagctgat gtgcaagatc aagatacgtt gtaggttcat ccagcagaag cagttccgtc 3066841 ccttgcgcaa gcgccatggc aatccacaca cgttgacgct gtccgcctga caatgcctca 3066901 atcggccgtt cagcatattc agccatgcct gtttcttcaa gcgcccattt gataatccgg 3066961 cggtcttcgt catttaatct gccgaatcct gattgatgcg gaaacctgcc gtacgacacc 3067021 aattcgtgca ctgttaggcc gctcggcgct tcaggtgtct gtggaagaat cgccatatct 3067081 tttgcaatgt cctttgtaga cattttatga atcgctttgc cgtttaaata gacggcacct 3067141 gcatgtgaac gcataattct ggacattgtt tttaaaatcg ttgatttccc gcagccgttc 3067201 gggccaatta aggtggtaat tttcccttta ggaatcgata tatttaaatc ctctacaatc 3067261 accctgtcgc cataaccgat tccaagctgt tccgttgata atgaattcat attcggcccc 3067321 ctcctctaat tcgctttcat caataaataa ataaagtaag gcgcacctag cacggaaatg 3067381 acaagtccga ccggaatttc tgatggtgcc aatacatttc tcgccagcgt atcagcaagc 3067441 aaaaacagga atgagccgat gaaggcggag accggtatca gcgtctggtg acgtggaccg 3067501 gtcagccttc tagccacatg cggcgcgatc aatccgagaa acgcaatgcc ccccgcagct 3067561 gccacgcatg aagcggcaag agtgaccgct gccagaagaa gaatccgtct ttccttttca 3067621 acagcggtgc ccagcccggt cgccaattgg tctccgagct gcataatgtt caaatagcgt 3067681 gccttatata aagtaaacag aagcaagatc acaatccaag ggagaatcgc ccagatcata 3067741 ttccagttcg ccccccatat tgagccggat atccaaaccg cggcttgcat aaaatcatga 3067801 gggtccatct tgagctgaaa aatcagcaac agggcgttga atccggcatt cacccctatg 3067861 ccgactaaaa tcagccgaat cggtgtcacg ccttttttcc atgccagaat ataaatgaga 3067921 aacgcagcga ggattgctcc tgccaaagca ctgaacggca gcataaatgt tccgaaaaag 3067981 ctaagatctg aagctgaccc ttgaaaaaag tatataaaaa gcactacagc aagtgaaccg 3068041 ccggcgttaa ttccgagaat accaggctcg gcaagttcat tttgagacac gctttgcaaa 3068101 atggctccag ctacggagat ccctgctcca acaagcaaag aaaggatgat ccggggcagc 3068161 ctgaactcaa ataagacaag ttcatcacgc gccgttcctt ggccgaaaaa gacctgaagc 3068221 gttttaagcg gtgcaatttt gataacgccc aaattgagac tgataaaaaa gaccaccacg 3068281 ataagcaaaa aggtcacagc cattacaatg agcggtttgt ttgtttttgt tttcattaca 3068341 gccctctcct ttcacgacgt gccaaataaa agaaaaaggg aacgccgata agagaagtca 3068401 gcgcgccgac aggcgtttca aagggcgcat ttacgagtct ggccgctatg tcagcaaaaa 3068461 caagcaaaac agcaccgagc accgccgagc aaggaatgat ccaccgataa tccacaccga 3068521 ccaaaaaacg ggtaatatgc ggaatgatca gcccgataaa tgcaatggtg ccggcaatgg 3068581 aaaccgcagc tccggtcaga attactacaa taagcatgcc aaccagtttc accgctgatg 3068641 tatattgtcc aagccctttt gccagatcgt caccgagact taacactgta acagaccggg 3068701 cgatgaaaaa cgcgagcgtt aaaccgacag cccctgcaat aagcaaaagc tggacccccg 3068761 accatttcac acccgctacc ccgcctgcgt accaaaagct gatatcctga gcgacatcaa 3068821 agcggattgc aatggcagtt gaaatgccgg taaagaaata agtaactgcc gtacccgcca 3068881 gagcaagctt tacaggcgta agtccgcccc ttgaaaacat gcctatgccc attaccgtcg 3068941 atgcccccag ccccgctccc gcaaaggacc atagcacaag ccccattgca gaaagtccgg 3069001 gaaaaaaggc aaacgcaatc gaaaccgcaa acgcagagcc tgatgtcaca cccataatcg 3069061 aaggctctgc caaagggttt ctcgtcatcc cctgcatgat tgctcccgac actgccaaca 3069121 atgcgcctac aagcgcggca gccgccgttc tcggaagccg aagatcatgt ataatttggt 3069181 gagatgtctt tgtcggctga taatgaaaaa tggcctccca tacagtgcgc aaatgaatat 3069241 ccgctgcacc tagggatatg gataaaaatg cgccaaggca aagcaggcat agacctgcga 3069301 taaggacgat gaccgcgcca tatgtccttg acgtccattg gatttcttct gatgcagtcc 3069361 gtatattttt atgttgactc aactgccgta cttcctttct gttactgata atgattatca 3069421 attgctgttt cagtatatca cttttttcag ctgatttaat agagtgtttt gaacaaaaat 3069481 gaaaatgcat ttgcaaaaat atcgtgtcaa ccggcacttg cagtggtata atcacagatg 3069541 ataatgattc tctttttcat ctatctttta gaaagaaggt atgagatatg acccatatat 3069601 acaagaaact cggagccgcg ttttttgccc tgttattgat tgcagcgctg gcagcctgcg 3069661 ggaataactc agaaagcaaa ggttctgcct ctgattcaaa aggcgcagaa acctttacat 3069721 acaaggctga aaacggaaat gtaaaaatcc cgaagcatcc taaacgggtg gttgtcatgg 3069781 cagacggcta ttacggctac ttcaaaacac tcggcatcaa cgttgtaggt gcgcctgaga 3069841 atgtatttaa aaacccttac tacaaaggaa aaaccaacgg cgtcgaaaac atcggagacg 3069901 gcacttcggt tgaaaaggtc attgatttga accctgacct gattatcgtc tggacaacac 3069961 agggcgctga tattaaaaag cttgaaaaaa ttgcgccgac tgtcgcagta aaatacgata 3070021 agctcgacaa catcgaacag ctgaaagaat ttgcaaaaat gacgggaact gaagataaag 3070081 ctgaaaaatg gctggccaag tgggataaaa aagttgcggc cgctaaaaca aaaatcaaaa 3070141 aagcggtcgg tgacaaaacc atttccatta tgcaaacgaa cggaaaagac atttacgtat 3070201 ttggtaaaga ctttggaaga ggcggaagca tcatttacaa agacctcggc ctgcaggcta 3070261 caaagctgac aaaagaaaaa gccattgacc aggggccagg ttatacaagt atttcattag 3070321 agaagctccc tgacttcgcc ggagattaca ttttcgcggg cccatggcaa tcaggcggtg 3070381 atgatggcgg cgtttttgaa agctccattt ggaagaacct gaatgccgtt aaaaatggcc 3070441 atgtatacaa gatggatccg atcggattct atttcacaga cccgatttca ttagaaggac 3070501 aactggagtt tattacggaa agcttgacta aataaacaaa agagccgcct gcccgcggct 3070561 cttttgctta tttataagga acggctcaat ttgaatcata tcggatattt tctttgagcc 3070621 attcatatta agctgcatcc tcatcacgat cagttttttt atgctggaga gactgaaaaa 3070681 cgttttttgc atatttaacg aacggattcc taacaggaga aattgtgatt ttataaaaaa 3070741 gacacctgag caaatcaggt gtcttttcat tatgcttgtt tttctttctg gaacttgtta 3070801 ctcacaaatg gataaacgat taagccgaca aagaataaac cgatgccgag tataaatgtc 3070861 gttaaatctg ctgtgcctgt tacgataaca aacacggagt atgcacacgc cagtatcgcg 3070921 atcaatccgt ctcttacacg ggagcctttc agctggtcat acgtttcacc tttgatgact 3070981 accttcaagc tgtagattgc agataccaga tacggaatta aatatgcgag tgtagccgct 3071041 gtcgttaaaa atgtaaatgc gtcacttatt gtccgggaaa taaccgagaa aatgaagacc 3071101 tgtgacatga cgtttgtaat aatgagtgca atgaccggac ttcccttttt attcgttttt 3071161 gcaaaaaatg ccgggaaatc tcctgcttta gcggcttggt atggcacctc agagccaagc 3071221 aaaatccagc cgagcatcgt tccgaataaa caaaggatag ccaaaagcgc cataatcacg 3071281 cttcccgcgt ttccaacaat cgcatagagt acatcaacaa atggtttttc agagccgaca 3071341 agcttatcat gcggcagaac acccatcgta attaaagtca caataatata tatgctcaag 3071401 gcaatcagca agccggtaat tgtcgcacgt ttcacatcac gctgagagcg cgcacggccg 3071461 gacaggatca ccgcggattc aattccgaca aacgcccaca gtgtagaaat cgcagcgtta 3071521 tgaacctggc caccaattcc aatgcttgtg ccgttttctc cttgaaccgg gaaataaaaa 3071581 tgaccgaata atgacgtttg aaacacaaac aaaccggcaa cgataaagaa gacaaaacct 3071641 aatactttag aaagcgttgt gacaaagttt aatttacttg cgccgttaat gctggcaaca 3071701 agaatcgcgt gcgttcccca taacaagatc gtacatacgg caaacgtcag taattggccg 3071761 agtgtcacct cttgcccgcc gatcgaaaac atctcacgtt tatcaaccaa gatcgggaag 3071821 aacgaagtca agtaaccggc gagacttgtg atgatcgcca cgttactgat ccagctcgcc 3071881 acccagtagc cccacaccat tgtgaaaccg gcagcgttgc cttttttcgg gtcagaaaac 3071941 agcgctcttg cataactttg cggtcccgct gtcagttcag gcttgcgaat ggacaagtgt 3072001 ccgaacacaa gtgcaatcat cagcacgccg gcacctgtca aaagccaggc ggacgtagct 3072061 ccaaacggac tcgcaattga agcaagcgag ctcggcaagg agaaaattcc tgatccaacc 3072121 atatttccaa cgacaaacgc cgttaataac caaaaacccc atttttttgt ctgttccatt 3072181 ccagtacctc catgattctt tgtacggacc agaccccgag atcatataaa cgcaaaaaaa 3072241 gcctgaacaa aagtccatgc ttaaagaaac acacaccctt gatctccgga tagccctccg 3072301 cgaaaaagca cgcggcagtc ctgcacttat tcagatacag tcccagcata gagaaggatc 3072361 ggctttctcc acacttcggc gctgatgcct tttacacatg tttaacagcc cctgtcagcc 3072421 tagcatgtgt gactcatcat ccgcgcaacc tctacctcac tgagaaagag tgaggattta 3072481 attattcagt tactcccaga aggttatcaa agaaaggatg atctgtcaaa gggaacagat 3072541 ggaaaatacg gatagagcca agccctatcc gcatgtggtt atcgattatt tttctttttt 3072601 tgcacagctt cttgaagcgg atcatctttt agagctgaac cagcatcttc aagagctcct 3072661 tggattacgt ttttttcttt ttcggaacgt tttcctttat ctttattaaa gaaacccatt 3072721 cgtatcacct cttttaaaaa ataggtacat gtttaagatg cctttttcct gaaaaattat 3072781 gcgggatatt ttttatcgtc caaagtcctg ttgatcaaac atacattctc ttgatatatt 3072841 tgtaattcag agattttttg caaaagataa aaggagaagc ggcaaatgac aggaaaaaca 3072901 cacatcatgg gaggcatcgc ttcttgtacg gcagcggctt attattatgg atttgatcca 3072961 gtgcttatgg ctgcgtcagg cgcggttgga gcattaatac ccgatatctg ccacacacaa 3073021 agcaaaatcg ggagaaaatt tcctatttta tcgaaagtgg tcagctccgt ttttggccat 3073081 cgcaccttta cacacagcct gctgtttatg ctcatcatgt tttttatcac ttctacatac 3073141 attccagata aaaacatatc agccggcctg atgatcggaa tggcgagcca cttgattctt 3073201 gacgcttgga cggtgaacgg aatcaaatta ttattccctt ccacgatccg cgttcggctt 3073261 ccattatata tgaagacagg cagtttttct gagcagctcg tgctagccgg cctgaccctt 3073321 gcttcatgtt actactttta tatgctgttt catggccgca tgttttaaac atgagtgctg 3073381 agacttgtct gaaccggctg tttttagtag gttttactta agaagcattt catgcagatg 3073441 atcaagaaaa cgtgaggagt catattgatg aaaggaacct tttttcacaa tcagcggttt 3073501 ttatgttttt cgatcttatt tatgtggatc aaaacgtatg tgatatataa actcggcttt 3073561 gatttgcaaa tcgatactct gttggaggag ctaatgctgc tggtcaaccc gctcagcttt 3073621 attcttcctt tattcgggat cggcctgttt ctaaaagaaa acaagcagcg ggcctttttg 3073681 ctgattgcca atttggttct gactgttatc ttgatctcta atacgatttt ttacggcttt 3073741 tatatcgatt ttattaccat cccggtttta tttcaggcca gcaacatgag cgatatgggc 3073801 agcagtgtaa aagaactgtt ccatcctctg tttatcgccc tgtttgtgga tttggttttt 3073861 ctgctgttgt tcgccagaaa aaccaaacac ccacagacaa aagccgctcc ccacacgatc 3073921 aaacggtact atgcagcttc ctgcggaatg cttttatgca cactggcact tgcagaagta 3073981 cagcagccga agcttttggc acattctttt gaccgggaaa tgctagtcaa aagcatcggc 3074041 ctgtttcagt tccatattta cgatacaatt tctcagactg ttaatatcag cgcgaaagct 3074101 tttgccgatg aagacagtat aactgccatt aaaaactaca cagaggctga ttacagcaag 3074161 cctgatcaaa gcaaattcgg tcttgcaaag gggcgcaatg tcatctttgt aacacttgag 3074221 tcgacccaaa gctttgttct gaatgaaaaa gtaaatggaa aagaaattac cccatttatg 3074281 aatgatctca taaaaaaaag ctattccttt gatcatttct atcagcaaac agaacaaggc 3074341 aaaacatcag attcagaatt tatcgtcgct aactcactgt atccctccct tagcggcgcc 3074401 gtctttttca cgaaaagcga ccatcaattt catacgatgt ataaatcgct gaagcagcac 3074461 gattattatt cagccgtctt tcacgctaac cataaaacat tttggaacag agatgtcatg 3074521 tacgatacat ttggcattga ccgctttttt gatgttgatg attttcatgt cactcccggg 3074581 acatcgacaa gctggggctt aaaagacaaa gaatttttag agcagtccgc caaaaagctg 3074641 aaaagcctac cgcagccgtt ctacagcagt tttatcacgt taacgaatca ttttccgttt 3074701 gagattgatg aaaaggatca gctgatagat gaattcgatt caagcagtga tctgttaaac 3074761 cgctatgtga ccacggttcg ctatgaggat gaagcattga agcattttat caaaaaactg 3074821 aaggacgaag gcttatacga aaattcgatg atcgtattta tgggagatca ttacggcatt 3074881 tctgaagccc ataacgaggc aatggctgag tttttaggga aagacgaaat cacaccgtat 3074941 gacaacgttc agctccagcg ggtgccgttt atcatacata tcccgggaat caccgatcaa 3075001 cagccggaaa ccatccctga tgccggggga caggtcgacg tcaggccgac gctgatgcat 3075061 ttgctcggcg ttgagacaaa aggcgatatc caattcggca atgatttgct gtcgggcgac 3075121 cgcaccccat tcgccgttct gcgaaacggc agctttatta cgaacgatta tgtatacaca 3075181 aagaacacgt gctatagcca aaaaacaggt gaagtgctgg aagatcagga tgcgtgcctc 3075241 ccttacaagg agaaagcaaa cgaagaactg tctctctctg ataaaatttt aaatggtgac 3075301 ctgctcaggt tttccgaatg aaaaaatccc tctatcaaga gggatttttt acgtttccaa 3075361 tatcaccttg ccagtcagct tcgtttcata gccgtttaaa tgagacagat tcgccttgta 3075421 gtcctcagaa ttcaaaatct ccttcacggc tttgagcaac tgctcatttt ttttcaaaac 3075481 aacgatatca tattgttcgt cgatgagcgg gataaaatca acactgccca tatgtgccgc 3075541 gtgctgtgcc ccgattcccg cgtcagcctg tccgcttgaa acttgtgaag cggcagcgta 3075601 atgatcagtc acgatatcgc catatcccac tacatcagcc ggattcacac caagcaagcc 3075661 aagctgttca tcaaggagca cccttgcgcc agaacccttt tccctgttga tgatccggat 3075721 atcggctctt ttcaagtctt tccagccttg aatgtttttc ggattccctt tttgcacata 3075781 cagtcctgct ttgcggagaa cgacattgat gagacaaaac ggttcacctg tcaaaatccg 3075841 ttttacataa ggcgcgttat actggcccgt ttctgcatcg tacaaatgga ggctgacaat 3075901 gtcacacttg ccttgataca tatcaatcag gctgtttaag cttcctttgt atttacggag 3075961 cggcgtctcc tgaatggcat tctccaaatg cttgctgagg atatccatcg aaatgtcctg 3076021 tccgctgatc atgacatttg gtctgccgtc cggctcagcc tcctgcacct gtttcggcgc 3076081 ttcttttgca gcgatgggct gagacattct catattcgtt ttatattgct ttaaatcttc 3076141 ttcatccaca cgcatctgcc ttccgacacg gtaagcaggc agcacgcctt ttttaatcaa 3076201 gtcataaacg gtcagctttg ataccttcag cagacctgca acttcttcta tcgtatagga 3076261 agaggtttca ttcatcatca tcactctcct attttattat accttttcgc cgaatgtaaa 3076321 aaaacccaca taaaccaaac ataatcagtt ataattagtt atatctaatg ataaggggtg 3076381 caatcatgtt taagaagtat tctattttca tcgcagcctt aactgctttt ctgcttgtag 3076441 caggctgttc ttcaaaccag tcttcaacgg acagcgagaa aaaagtaacg ttaaccatct 3076501 cagctgccgc cagcgcgcag gatgcacttg aggaaatcca aaaaaattat gaaaaagatc 3076561 atcaacatat aaccatccaa gataactatg gctcatccgg cgccttgcaa aaacagattt 3076621 ctcaaggagc aggagcagat ctgttcttct cagctgctga ggataaattt aaaaagctgg 3076681 tggatgatgg agatatcgca aaaaaagaca gcactgaatt agtcggtaat gaaattgtgc 3076741 tggtcgtacc gaaaaacgga gattcacctg tgacaagctt cagcaatctg gctgaatcag 3076801 aaaaaatcgc tcttggcact ccggaatccg taccggcagg agcttatggg aaagaatcac 3076861 tgacaaagct gtctttatgg gacaaagtga aggataaaat tgtgtatgga aaagacgttc 3076921 gccaagttct ttcttatgtt gaaaccggca atgtagacgc aggtgttgtt tataaaacag 3076981 atgccctagt ctcgaaaaag gtcaacattg ttgacgaggc aaaagcagat acacacagcc 3077041 caattgtcta tccgttagga atcgtaaaag atacaaaaca ccgtaaggaa gcgaaggaat 3077101 tttacgaata cctgcaatct gatgaagcaa tgaaagtatt tgagaaatat ggctttactg 3077161 ccgagtagca taagcgcttc agaatttttc acacccgttg tgctttcctt tcaggtggcg 3077221 gcagttgccg gaattgttgt cattattctc ggaacacttg ctggagcatg gatgtcacgg 3077281 gcatcatttt tcggaaaaac ggcactcgaa acatgtttta tgcttccgct cgttcttccg 3077341 cctactgttg tcggttttat tctgatcgtc attttcggaa agcacagctt catcggacaa 3077401 gccatcgagt ggattttcca gcagcctgtc attttcacct ggtgggccgc tgtgatcgcc 3077461 tcggctgttg tagcctttcc gcttatgtat caatcagcca aaaccggatt tgctgacatt 3077521 gatcccgata tacaaggtgc ggcaatggta gacggcgcta gcagatggaa agtgtttatc 3077581 catatctccg tcccgcttgc ctatccttcg ttactgaccg gaagcatcct tagccttgcg 3077641 cgggcgctcg gagaatttgg cgcaacactc atgtttgcag gaaacatccc cggtgttacg 3077701 caaacactgc cgacggcgat atatgtcgca ttggattccg gcaacaatac ccttgcttgg 3077761 gcgtgggtcg tctgtattgt tgtcatttcc tttttgatgc tgtttttcat tcaacagaaa 3077821 aaaacgcact aaaaaaactc cccataacgg ggagtttttt gattaaaaca gaagctcatc 3077881 aggatttgga ccgacacgct catctttatt taatgcgtca attttgtcca tgtcttcttg 3077941 agacaattcg aaatcaaaaa tatcagcgtt ttcgatgata cggtgttctt taatggattt 3078001 tggaatggtt acaactccat gctgcagatc ccagcgcaaa atcacttgag ccacagattt 3078061 attgtgtttt tcagcaatct gtgtcagtac ttcgttatcc aaaagctgtc cctgcatgag 3078121 cggagaccac gcttccagct gaatgccttg ccctttgcag taatctctta attctttttg 3078181 cgtcaagcga gggtgaaatt caacttggtt caccatcggt ttgatttcag catctttcaa 3078241 cagctcttct aaatgatgaa cttggaaatt gctgacgccg atcgcgcgaa ttttgccgtc 3078301 tttgtacagc ttttcaagcg cgcgccatgt atctttatat ttatctttgc caggccaatg 3078361 gatcaaatat aaatctaagt aatcaagctg cagtctttct aggctttttt caaaggcagc 3078421 aagcgttgtt tcatagcctt gatcttcatt ccacactttt gatgtgatga agagctcttc 3078481 tcttgccaca ccggattctt taatcccgat gccaacgcct tcttcatttt tgtagatcgc 3078541 tgctgtatca atactgcgat agccattttt aattgccgct ttcactgatt cagtcgcttc 3078601 attaccattt tctactttaa aaacgcccag accgaaccaa ggcatttcaa ctccgttatg 3078661 taactttaca gtatctttta aacttgttgg cacttgaacc tccacccttt cactgaaatg 3078721 taagcgtcta tattatctca cattcctctc agccgatacc aataatacgc ttaagaccct 3078781 ctttttgctt cttttttcac agcacaggca aatccaaaca ctattttttt cctattttaa 3078841 caatattgag attacaaata cattgagcag ggtatgcgtg tagtgtaacc aaatgaaaac 3078901 aaaggaggaa acaacttgaa acgtattcgt atcccaatga cacttgctct tggtgccgct 3078961 ttgacaattg cccctttgtc ctttgcttcc gctgaagaaa atcctgctcc gaagatgtcg 3079021 cagacaacta ctgctggaac aactgccgct gatgtaggtt taaacgtcaa cctggatgta 3079081 cttggaattg ccaaccagat cgctgatgcc atcaaatccg cacagaatag ggatggcttt 3079141 gtgaaaaacc tcatggagtc ttccttctac gcgtccggcc aaaaatataa cgtcatggtc 3079201 tttaatttaa gccaggaata tgaagatcat ttgaacggtg tgcaatttta cggctcagcc 3079261 gtttacgacg gcattacgta tggcatttgg gtatttgaag atggaacctt tacaaacaaa 3079321 ggcgatggcg gctggatcaa ctgggccttc agaggctggt tcgaccggga tggcagcact 3079381 gtcgcatttc atcgccctta atataaaaaa agctggcgct ctaacgccag ctttttttct 3079441 gcatttattc gccgccttca agcatggcgg cttcgacatc attaatgtat tggcgaagct 3079501 catgggagat gtcccgggaa atttccctct cttcgaagag cgtttgaatt tcatttctga 3079561 tcgcctgcac agccttcagc ttcacttcca gcttctgatt ttcaaaatgg gcacttgatt 3079621 ttaactcatg atggctgtgc tccagcctga aaattaactg cttatagaat gtaatgacag 3079681 ataaaaacac ttctttatgc tcatccgtct tatgtttttc cagatattct atcgctgctt 3079741 ttgccgtttt cactcttgtt gcccgtatca atcccgcttc atttaaaatc gacatctccg 3079801 gctttttatg ttcaccgaag aaaatccaat acatcagcct cttgagcctt gtttttgata 3079861 acccgacttt aaacgggttg gcatacaaaa tttccaactc gttaaatcgt tcttgcagca 3079921 catttgctgt ttcttccggg atgtctcccc gctccagcat tttcatcagc gcctcttgct 3079981 cagccttaac cccctgcgca cggacttttc gctcgtgctt cttaatgcga ttagatgatg 3080041 tatactgctg aaaacgaaga tttttcattt tctcattgta ttcagctatc accgcaagag 3080101 aggccgtttt gtttgtctca ttcatgtcct ctttaatcgt ttgaagggct gttttgatca 3080161 acttgcgtct cgccgtcagc agcttcttat ttcgttcctc gtcctcttct tctttttcag 3080221 tcagaattgg cagcacaacg gtggcaatga caagcgtgca taaaatgacg ccggctgcta 3080281 aaaagagaat cagatttctt tccggaaacg gcgtaccgtc ctccaggaaa tacggaatgg 3080341 aaaaagaacc tgcaagcgtt actgctccac gcacaccgga aatcgaaatt aacagcgtcg 3080401 aacgaagacc cggtttatag atgttctgat ctttattaaa gaaccatttg ccgttccaga 3080461 agaacagcac ccacaggaat ctaaggagca ttaatgtaaa tgtgatgact aggatatagc 3080521 cgatcacctt catgttgctg atggcagtgt cgttaaagat aacagaaata acatcaggga 3080581 tttgcgtgcc gagaataacg aagaccaggc cgttcaaaat aaataaaata atgttccacg 3080641 tacttgagga gacgatttgc agcttgatca tcgttgattc cagacgatcc tgttcaaccg 3080701 catgggtaat accgccagct acaacagcta aaatgcccga aacgccgatt tcttcagctg 3080761 ccaaataaat cacaaacggc gtcagaattt gaatcagcat atgcatcgtg acatcctgca 3080821 tgccaaggcg gcgcagaaat aggcgaaaac gaataatcaa aaatgaaatg acaaccccgc 3080881 acagcaagcc tccgagagaa ataaagacaa agctgacagc cgcttgtgct aatgaaaatg 3080941 caccagtcac tgccgctgca atcgcaaact taaaggccac cagacctgat gcatcattca 3081001 tcagcccctc accttccagc aggcgaagaa tcccttttgg cattttcact cttcctgata 3081061 atgcgctgac agcgacgaca tcagtcggtg aaagaatggc cgcaagtcca aaggccgctg 3081121 ccagcggaat agcaggaatc atccagtgaa tcgtgtagcc gcctacaatc acagtcgcaa 3081181 atacaaggcc gagtgcaagc aataaaatcg gagcccttaa attccaaagc tctgcccgcg 3081241 gtgtcctctt tccatcatta aatagcagag gcgcgataaa aagaacaaaa aacaattcgg 3081301 tgtttaattc aaaatgaagt ccctgtggaa atgaggcggc aagaatccca agagccactt 3081361 gaatcagcgg caccggaata aacggaataa accggttcac gatattagaa atcgcaataa 3081421 tcgttaataa tacgagcaca actaaaaata tgtccaaatg catgacctcc ttcgtctgtt 3081481 gtgtgtcggc atgatgagcc aaaaaatctg tttgtctaaa agcccttgag ctagggtggc 3081541 cttgcatccg ctatgtggtt tcgcaggagt tctctccaca cttgtcttct tttatagtac 3081601 cctttttagg gtattttttc tcatgatatg ctcacagtga acttttttgc agaagagcaa 3081661 attatagaaa aaagagacag gaagctactc cctgtctctc gtctttcttt ctcaatcatg 3081721 aaaattcgta ccgtcagttg ttgctttaat aatgcccgcg cgaatgacaa agtcaccgaa 3081781 atgctcgcct tcctcgcgtt ctttcgcata gcgggaaaga aggatgcgca gctcgcttaa 3081841 aatgtctgct tcaccgatgt tttcacggta cattttgctt aaacggcttc cgtcaaacgc 3081901 agcgccaaga tacatattat atttgcccgg cgcctttccg ataaatccga tctcaccgag 3081961 tgcatgacgt gcacagccgt tcgggcatcc tgtcatgcga atggtgattt cctgatcacg 3082021 aaggccgttt tcgtcaataa tctcttcaat cttatctaac agggtcggca aataacgttc 3082081 tgcttcagcc attgccaatc cgcaggtcgg aagagcgacg cacgccatcg agctgcggcg 3082141 aagcgctgaa tagtgcttgc cgtcagttag tccgtactgt tcaattaaag cactgatttc 3082201 ttctttttta tcgcttgaaa cgttcgcaat cattaagttc tgattggctg tcagccggaa 3082261 ctcacctgta tgaactttgg cgatttcccg caagccagtc atcagcttat aatcatcgta 3082321 atccgttata cggccgcctt cgacaaacag cgtgaaatgc catttatcct cgatgccttc 3082381 cacccagcca tagcggtcgc cgttatgatc gaaatgatac ggcttcgctt cttccaggct 3082441 ccagccgaga cggttttcca attcttcttt tacgttttct aaaccgaggc ggtcaactgt 3082501 gtatttgaac cgcgcatttt tacggacaga acggttgccg taatcacgct gaatcgtaat 3082561 cgttttttca gcaacgtcat acatttgctc aggccggcag aaaccgatca ccttggctaa 3082621 ttgcggatat gtcgcagtat cgccatgcgt cattcccata ccgccgccga ttgccacgtt 3082681 aaaaccgatc agcttgccat cctcgacaat cgcaatgaat ccgagatctt gtgaaaagac 3082741 gtcaatatca ttagacggcg gaacggcaat accgatttta aacttccgcg gcagatagag 3082801 cggtccgtac attggctcga cttcttcctc cggcgtgccg gcaactcttt cctcatcaag 3082861 ccaaatttca tgatatgctc tcgtccgcgg cagcagatca tcacttaatt ttttagacca 3082921 ctcgtatacc tctgagtgga tttcagattg ataagggttt gatgcacaca tgacgttacg 3082981 gtttacgtct ccgcaggctg cgatcgtatc caaaagtgct gagtggatcg tctgaatggt 3083041 tttcttcatg ttccatttca gaattccgtg catttggaat gtttcacgtg tcgtcaattt 3083101 taatgtgccg ttcccgtatt tctgggacag gtcatccatg acaagccatt gttcaggcgt 3083161 cgagacgccc cctggcatac gcacgcgcag catgaactga tatgcgggct caagcttctg 3083221 cttttggcgt tcatttcgga ggtcgcggtc atcctgcaaa taactgccgt ggtgtttcat 3083281 caggcggtta tcatcatccg gaattcccgc actgattcga tcgagcatca cttctttcag 3083341 cgtgccgcgc aaataatcac tttctttttt aatgcgttca acatcacttg gagagccgtc 3083401 cggtgctttt agaattttgg tcaccatgtt gaaaaactcc tttcaagtca aatcaatata 3083461 catcacgctg atagcgtttt tgctgctgca tatcggcaag ataagcctcc gcctcttcgc 3083521 ggctcatatt gccttctttt tcgataattt caagcaatgt gttatggacg tcatgcgcca 3083581 tgtgcttttc atctccgcaa atgtaaacag ccgctccttc ttgaagccat tcaaacaatt 3083641 ctgcgctatg ttcaagcatg cggtgctgca catatacttt ttcttccgta tcacgtgaga 3083701 acgccacatc catttttgtc agcacaccgt ctttgagcca attctgccac tctgtctggt 3083761 aaaggaaatc cgtgacaaag tgctgatcgc caaagaacat ccatgccttt ccttccgctc 3083821 ccgtctcctc acgctcctgc ataaacgaac ggaaaggtgc gacgcctgtc ccagggccca 3083881 ccatgataat cggtgtttca gggtctttcg gaagcttaaa gttttgattg tgctgtacat 3083941 aaaccggcag tgtgtctccc ggctgcagtc gttccgcgca caaaatcgag cagacgcctt 3084001 ttcgttcacg gccgtgcgca tcgtagcgga ctgcgccgat tgttaagtgc acttcatccg 3084061 gatttgcgga taaactgctt gcaatcgaat aaaggcgggc aggcattttt cgcaaaatcg 3084121 agacaaactc ctgcgcagat acactaaatg ggccatagtc acggacgaga tcaagcaaat 3084181 cgcgcccttc aatataggct tttacattct cctcatttcc cggggctaaa agctctctaa 3084241 gctcatcgtt ccctgtcagc tgggctgcct gttcaagaag cggttttgtg agaacggtaa 3084301 tctcatagtg agaaatcagc gcttctttca gcggtcggac atcaccttgc ttattaagcg 3084361 tcacaatttc ttccgggtcc caattcattt ccttaaggag cagctcgaca agttccggat 3084421 cgttttccgg atagacgccg aggctgtcac caggctcgta agtcaggcca gatccttcaa 3084481 gagacagctc cacatggcgt gtttctttat ttgatcctct gccgtttaaa tttaaatttt 3084541 ctaacacttc agcccgaaac gggtttgttc tggaatacga agactcaccg gtttgtgacg 3084601 cagccgccgg cgcaggcgcg gcgcttccgc ccccagcttc atttaatcct ttcaatacac 3084661 cctcaagcca ttcggctgcc ggttcatcat agtcaagatc gcaatcaacg cgcggagaaa 3084721 tccgttttcc gccgagttct tctaagcgtt gatcaaattc tttccctgtc tggcagaaaa 3084781 attcgtacga actgtcacca agcgccaaaa cggaaaagcg caggtcttca agcttaggcg 3084841 cccgtcttcc gtgcagaaat tcatgaaacg acagcgcgtt atcaggcggc tcgccttctc 3084901 catgcgtact gacgacgatt aaaagattgg ttaccttctt cagctgattc ggcttaaaat 3084961 cgctcatgga tgagacggtc acttgaaaac cgctctgttc aagctgcttg ccggcatttt 3085021 ctgcaagccc ctgtgcgttt cccgtctgtg aaccataaag aacggtcact tcttttgaaa 3085081 cggccggtgc cggtgcttcc gctgacacag ctgccgccgg cgtacccgca gcttcttggg 3085141 cggaaacaga ttgagcggat aaatatccgc tcagccagat tttctgggat tcggtcaagg 3085201 tcggcagaag gcggttaagg agctctgcct gctcctgatt aaacggactg ttcattacct 3085261 gaagttgcaa cgtatccacc tcacaaagtt ataaactgat cgaaaattgc atctaattga 3085321 actttaccgg aatactaggc ttaagtaaaa tatatttaca tgatgataac tattaagaat 3085381 cctaatgata aaacggctat gcttcatgta aatagaaaaa agagaaggac tcccttctct 3085441 tcattcagca atctgatata agtgaggcgg cacagcggtt acaaacggac tggcttcacc 3085501 tgtataaaat accgccagca tgtgcatcgc acgggtgcac gcagtatata aaagcctgcg 3085561 gtcgtgctct gtatgatagt gttcttcaga tgcatcatag acaagcactg cgtcaaattc 3085621 aattcccttc gctaaataca ccggaatcac gcaaacaccc ttttgaaatg gttgattttc 3085681 tttatgaatc aggcgaacat ctgtatattc actcatgtgg gcgtgcgcct gtatgcattg 3085741 atgcgcagtc ttgcagatga cggctattgt ttcgtgccct tttttcttga gccggccaat 3085801 ttcttgcgcg agcttttggc aaaggctctc atgtccttca gttttgacaa cgagcggcat 3085861 ttccccgctt ctattaaacg gctcaatatc cgctccatct tgaagcatcg ctttggtaaa 3085921 ctcgacaatc tgccttgttg atctgtatgt tctctttaaa cgaacatact cagcaggctc 3085981 atcctcaaag cacgcatcca tacgctgatc cccgtttatg gtatgcgcgt agatggactg 3086041 attgatatca ccgagcactg tcatgctggc agccggaaaa atgcttctca tgtaagccat 3086101 ctgaaacggt gaatagtcct gggcttcgtc aataaataga tgtttgattt tcgtattttt 3086161 ctttctgccc tcaatcagat cctgcatata aagaaacggt gccgcgtcct catagagcaa 3086221 tttattatcc gtaaatgccg aacgggtcag ctcacctatc gcatccatct tctcatgttg 3086281 aaattttcct ccccagccag aaaacaattg caaataaagt tgtgtaacat caagaaatgc 3086341 aaggagcctg actgcctgtt tgagcggttt gaaagctttt ttcacaatga tggcggcaag 3086401 cagctgctgc tctctttgat aatcgttaaa cgtactctcg ctgaaccgtt tcctttcctg 3086461 cagttttttg tacacgtcca agtagtcctc tttgtcaagc agctcagctt catgaacaac 3086521 ccaatccttt cgccgttcct ttttctcaag cttgttaagc tcactcagca gccacttcgc 3086581 ggtttgctcc atccgattcg gaatggagtg attttgatcc aatgagtaaa aataggattg 3086641 aatttgctcc tttgtgatca gcttttgtcc gcggaatata atatttttaa aaatcatccc 3086701 ttcagaggaa agccgtgtga cgtattcatt aatgaattgc tgaaaggata aacccgcctt 3086761 ccatgtgatt cctgcaagcc ttgttggaaa atcgcctccc tttgtttcgg tcaggcaata 3086821 ttcgagctga tcaaaggggc tttcacattt gaacttgcgg ccaagacgat gctcgatata 3086881 ttcctgaaac gtcgcctgct ccatattctc ttctcctaac tccggcaaaa cagaggagac 3086941 atagctgtta aataagaagt tgggtgaaaa caaaacgatt tgtccggcat caatgacacc 3087001 gcggtgcctg tataacaaat aagcgacacg ctgaagcgca gccgatgttt tcccgctgcc 3087061 agccgctccc tgcacgatca ggatcttgct tttttcatta cggataatct gattttgttc 3087121 tttctgaatc gtagacacga tgtttttcat ttgggtatca gagtgatggc ttaatacctc 3087181 ttgcagcatt tcatcgccaa tcgtcatatc ggtattaaac atcgccttga gagtgccgtt 3087241 tttgatcata aactggcgtt tcagcaccat ttccccttct atcgtttcac cgggcacctc 3087301 gtactccgct tttcctgggg aataattgta gtacaaactt gatatcggcg ccctccagtc 3087361 atagatcaga aagtgttcct ccttctcatc caaacaggaa gctaaaccga tataaattcg 3087421 ctctgcctgc tcctcgccgt tttcaataaa atcaatccgg ccgaaataag gcgatttttt 3087481 caattgatga attcgtttga gctgctgatc catgcgccga tgattgtgtt cccgatcaga 3087541 cagcagctct gcctgctgct taatgctagc catcgtttca atcgcttcat gggcatcatc 3087601 aaaattaacc ttaacatcct cccaaaagct ttttcttaat ccgatgatat catgcttcaa 3087661 cccgcccgca gacgtttcca gaaaccgctc ttttttttcg agctccttca gcacctcatc 3087721 tattctcgac tgctcttcct tccattcctt atcctgctga ttcatgaacg gcacctccag 3087781 aaaatagttg acaaacatag atgaaatact gtaaaatata attggataca tatattaaat 3087841 atatgatgca aactggcaaa tacaatttat aatagcacat tcacccaata ccaatcaagg 3087901 tttgggttat ttatattatg cagaaaaaaa ccgatttcac ttcgaaatcg gtttttttgc 3087961 tattaattat ctaagcgaaa agaacggttt ggcagcttcc aattaaacat ataggaacaa 3088021 acccggcaaa caacgagcac gaaaaacaga acgtataagc cgaacgagtt ccccagccag 3088081 cccaagccga cgattaaacc gccgagcgcc gcccataccg catagatttc cgctttcagc 3088141 acaagcggtt tgcgcccggc aagaaggtcg cggatgatcc cgcccccgct tcccgtcagc 3088201 accgcagcca cgatcacggc actaagcgga tggcccattt tgacggcata cagtgcgcct 3088261 tggatagcaa aggcagcgag gccgatcgca tctgataaat tgccccactt attccaatgc 3088321 ttcagcagca gcttcggaaa cagaaacaca attgtaatag ataaaagcgc gatttgaaag 3088381 tacgctccct gctcccatag cgctgacacc ggaacaccga tcagcaaatt gcggatcgct 3088441 cctcctccaa aagctgtgac aatccctaat atataaactc ctaaaatatc atattcctct 3088501 tccatcgcaa caattgcgcc gctgactgca aacgcaatga tgccaatcac actaagcagc 3088561 tcccaagcca ttctgatgac tcccttttat gtttgttaaa ttttctgacg acctctagat 3088621 tttataatcg ctccagcgta aaatcaataa cattttcatg agaaaaaaag ataaatttag 3088681 agggaatacg gctattgctg atggacatga gtttgcgaaa ttaaaaaagc gcccggcata 3088741 cgcgggcgct ttttttgtta ttcagatttt tcgcctttca gcaggcacat aaaaatgata 3088801 atcaggataa aagcaatcag ggccaggaat ggaatcgtaa taaaaccaaa ccagttaata 3088861 tattggcccg agcacggcac gccgctgaca catggcttaa tgccgctaaa gccgggcact 3088921 ttttgctcta agtaatgcat gatcgaaatg aatgccccaa taatcgccat cgggagcaca 3088981 tattttttca ctcgtgtgtc cccttgaaag gtggcgatgc ctaaaatcag gacgagcgga 3089041 tacatgagga tacgctggta ccagcacagt tcacatggaa taaactttct gatttcactg 3089101 aaatacaggc tgcccagcat agcgataaga gccacaaccc aggaagcata taaaaatacg 3089161 attctatttt tcatattgtt acttcccttt cagctctttt tctattgtct ctttgatttc 3089221 atcataatcc gcaaaatttt tgatcacttt atcattgacg taaatcgtcg gtgttgcctg 3089281 tatgttcatt ttttgattaa ggtcagaatc cttttccact tgagaagcga atgtttcctt 3089341 atcaagattt tccttgagcg tctcaggttt tatctttgtg gtgctttttg caagatcacc 3089401 aaggaggcct ggggttaccc attcctgttc cgtatccggc tgtttttcga acagcttttc 3089461 atggaaatcc cagaaagagt cagggtcttc cttccatact tcttcagatg caagagccgc 3089521 taaccttgaa ccttttccat ggaacatgac gttcacgaaa gaaaatttca catcgccctt 3089581 atcaataaag tctttttgta tttttggaaa gatgtcactg ttaaacacct tgcaagacgg 3089641 acatttgtaa tctccgaatt ctactacagt taccggtgca tcgtccttgc caagcacagg 3089701 ctgccctttg atagacggct gtccggacac cgcatcattg ccttgttccg ttttgttatt 3089761 aatgatgaca atggctgcta gcaatacaac aaccacaacc gtaaggatga ccgcgaattt 3089821 cgcagaagac tgctgtttct ttttcactcc gacacctcat cgttttaaaa ttaaaaaaga 3089881 agcggatcgc aattgaccca cttctttatt ttaacaagac aagcgctgat aagaaaaccc 3089941 cgaaaaaatg aattctctcc gacaatttat ttgtttttga gacgcatgac gcgcatggcg 3090001 ttcgccacag caagcagtgt aacgccgaca tctgagaaaa ccgcttccca catggtcgca 3090061 attccaaatg caccaagaat gagaaagatc gctttcacac ctaaagcaaa gccgatgttt 3090121 tgccacacga ttcgccgtgt ccgtttcgca atccgaatcg cttctgctat ttttgacggc 3090181 tgatctgtca tcagcacgat gtctgcggct tctaccgcgg cgtctgagcc aaggcctccc 3090241 atcgcaaccc ctatatctgc gcgtgcaagc accggcgtat cattgatgcc gtcaccgaca 3090301 aaaatgagtt tttcactagg caaaagctta gcttctaatg cttcgacctg cgcgacttta 3090361 tcttgcggca gcagctctgc atatacctca ccaatcccaa gctgttttcc gacggcttct 3090421 cccgtttgtt tcgaatcacc cgtcagcata gctgtctgtt tgatcccaag cgacttcaga 3090481 tcagcaaccg cctgtgctgc gtcttccttt atctcatccg ctatgatgat tgctccggca 3090541 tagcgttgat ctacagcaac gtgtacgatt gttccagcat tttcatccgg gacatcctca 3090601 atttgttctc tttccatgag ctttttattc ccagcaagga tctcagttcc atttaccttt 3090661 gcaaaaatgc cgtgaccgga gatttcttcg tatgactcaa tctcatcgga ggaaagcatt 3090721 ttcccgtaag ctttacgcac agattcagca atcggatgct gtgaatgaag ctcagcgtat 3090781 gccgccgctt caagtaatct atcctttgta aaaccttccg cgggtttgat ttctgtcact 3090841 tcaaagctgc cttttgttag tgttcccgtt ttatcaaaca ccgcgtattt gacttgattc 3090901 aaagcttcta aataattgct tccctttaca agcactccgg cctttgaggc cgctccgatt 3090961 ccaccgaaga aaccgagcgg aatagagaca acaagcgcac aaggacaaga aatcactaaa 3091021 aagataagcg cgcggtacac ccaatcggaa agcgcggcgc cagaaagaac aagcggcgga 3091081 acaaaggcca gcaataccgc aatgatcacc acagcaggtg tataatactt ggcaaacttc 3091141 gtgataaagt tttctgtccg ggctttacgg ctgctcgcat tctgaaccaa gtctaatatt 3091201 tttgatactg ctgattcctg atagcccttt gtgacttcaa tatgcagaac gccgttttga 3091261 ttgataaagc ctgacattac atcttgtcct tccgcagctt ttctcggaac ggactcacct 3091321 gttaaagcag atgtatcaac catcgctgac ccttgcacga ccttaccgtc caggggtatg 3091381 ctttctcccg gattaaccac aatgatgtct cctgtctgaa cgtcctccga cgaaacctgt 3091441 tcgatgccgt tctttgtttt gagattggcg taatcaggcc gtatgtccat taacgcacta 3091501 attgattttc tggaacggct gaccgcggct ccttgaaaaa gctcaccgat ttgataaaac 3091561 agcataacgg cgaccccctc agggtattgc tgaatcagaa aagcgccgat tgtggcaaga 3091621 gccattaaga aatgctcatc aaacacctga ccgcggatga tgtttttgac tgcgcggatt 3091681 ataatgtcac cgccgataat caaataagca ccgaggaaaa ggaaaaattc aatggttccc 3091741 gactgaacca aatatgccgc tgcgccgaga atgacagccg ccgccattct gatcagcata 3091801 ttgaccattc gattacgata gccatcatca gctgatttct ttatatgctt ttggcgaacc 3091861 gttacatgcg gatcaattga tttcactttt ttctctactt tattcgtgac ccattgctct 3091921 tctttcccat cggctgagac agttaaggtg cttgccgcaa aatttaccgc gcatccgtta 3091981 atgcctttta tgcctttgac tccattttcg atttttcggg cacaattgct gcaatccaaa 3092041 ccgtccagaa catattcctg tttcactagt ctcaccttac cttccgattt agggttccct 3092101 cttcaaagcg tatcaatgag tattgtattt attttatata tatgagcata tactcatata 3092161 taagttacac ctattatatg ttgttttcca agaaagtgtc aatgaaaaac aaaaaccggc 3092221 atatagccgg tttttcattt tactttttgc agacgaagag cattcagaac aacggaaacg 3092281 gagctgaatg ccattgctgc tcctgctatc cacggtgcta aaaatccaag tgctgcgatt 3092341 gggatgccga ggctgttata gccaagcgcc cagaataagt tttgtttaat gtttttcatt 3092401 gtcaatctgc tcatgcggat tgcgtcggca atgctgttca gatcgccgcg aataagtgta 3092461 atgtctgctg tttccatggc aatgtccgtg ccagttccaa tcgccatgcc gatgtcagct 3092521 gtggcaagcg ccggcgcatc gttaattccg tcgcctacca ttgctgtctg gcggccttct 3092581 ttttgcaagc gggcgatttc cgccgccttt tgttcaggaa gaacttccgc aatgatattc 3092641 gcaattcccg cttccttcgc gatggcttct gcggttctgc gattgtctcc tgtcatcatg 3092701 atgacatcaa gacccaactc tttcagacgg gcaacagcct tccgcgacgt atccttaatc 3092761 gtatctgcaa ctgctactag ccccgctgct tctccatcaa tggatacaag cataactgtt 3092821 ttcccttcgg cctctagctc ttccatttgg gcgagaagag ccccatgctc aacctgttcg 3092881 ctctccatta attttcttgt gccgacgaga atgctttttc ctccggcttc agccaaaatg 3092941 cctgcgccga cttttgcttc aaagcgggta agtttcggta tctcaagccc tttatctttc 3093001 acgccagcaa taatcgcttc gccaagcgga tgctctgatc ccgtttccgc tgccgctgca 3093061 aattgaagca aatctttttc ttcaaaacgg ccgaatggaa tggcatccgt cagacgcggc 3093121 ttcccgtttg tcacggttcc ggttttatca agaacaattg tatcgagacg atgtgttttt 3093181 tctaaatgct cgccgccttt aaataaaatc ccgaattcag cagcgcgtcc agatccagcc 3093241 attatgctcg tcggagtggc aagaccgagg gcgcaaggac aggcaatgac aagaaccgca 3093301 atgaacttgc tgatcgcttc ggcaaaatcg ccaggagccg cccaaagata ccaaatgaga 3093361 aaagtgagaa ccgcaatccc caatacaatg ggtacaaaaa tgcctgaaat ctggtcagcg 3093421 agacgctgga tcggcgcttt tgacccttgt gcttcctcaa caattttgat gatatgagaa 3093481 agcgcagtat cctttccgac gttgacagct ttaattttca gaaagccgtt tgcgttaacg 3093541 gttgaacctg tcacgctgtc accaggattt ttgtcaacag gaagactttc tcctgtaatc 3093601 atcgattcgt caaccgctga acggccttca accacttctc cgtcgacagg aattcgttcg 3093661 ccaggtttga cgtaaacaat gtcattaaca agcacttcgt cgatcgggat gatttgctcc 3093721 tgtccgtctc ttacaacagt agctgttttc gcttgaagct tcatcagctt tttaatcgca 3093781 tccgaggaac ggccttttgc ttttgtttca aacaacttgc ctaataaaat cagcgtcagc 3093841 aaaatcgcgc ttgtttcata ataaaggccg tctgtatgcc cgtgagagcc aatgctttga 3093901 aaagttagat aaagactata agcgtaagca gccgtcgtac cgagggcgac caatacatcc 3093961 atattggcgc ttttatttct aagcgcctta tacgcaccca cataaaacgg ccagccgatc 3094021 agaaactgga ctggtgtcgc cagcgcaaac tgcatccacg gattgagaaa tatatccggt 3094081 acccaaatga atgatgtaaa tgtaaaatgg ctcaccatcg cccaaagcaa tggaaatgac 3094141 aggacagctg aaaaaatcag tctcgccgtt tgcttccgtt cttctttctt tttagcagca 3094201 gcctcactgt cctgttcacc cttcaacttt agcttatatc caagcttatc taccgcttct 3094261 ttcaaatcgc tgacagacgc ttcttttgga ttgtattcga ccgtaactgt ttctaaagcg 3094321 aagtttactg gtgcatttgc gacgccttct attttgttaa gccgtttttc aatccgattg 3094381 gcgcaagccg cacaggtcat gccctcaata tcgaattcag ctttttctgt aacgacgtga 3094441 tagcccagct tctctatttt ttcctgaatc gctgcagtcc ctgtttcagc aggatcgtag 3094501 attacatttg atgtttccgt tgccagatta acatttgcat ccgtgacacc gggcatccgc 3094561 ttcaggcctt tttcaattct ggcagcacat gccgcacagg tcataccaga gacctgcatc 3094621 gcgatttcct tttgttcact caacatactc actcctttat atacacctgg ggggtatata 3094681 aaaatgaaag aaatatcgcg cctccctaaa ggcgcgatac cttgaatcac ttggctacgt 3094741 catagccctg atcttctatc gcatccgcaa tatctttgac tgatactttg tcagcatcaa 3094801 acgaaacatc gactttaccc gcttccagat tgacatgaac ggcactgacg ccgtccagtt 3094861 ctcctacgct tgtttctact gctttgacgc agtgctgaca agacattcct tcaacttgca 3094921 atgttttttg ttccatatca attcctcctg tttattcttt ctattttcat cctaccatac 3094981 ccccgtaggg tattacaata aaaaacgctt tatgattttg tgaacttttt aaatacgtcc 3095041 aaaagctcag aaatggcctg ttccccgtct ccgcttttga tggcatctgc tacacaatga 3095101 tgggcatgat cctcaagcaa atgaagcgcc acatttttca ttgccgcctg aacagctgaa 3095161 atttgcacaa gaatatctac acaatatctg tcgttttcca ccatgttttg aatgcctctg 3095221 acctggccct caatccgctt aagccggttt gtaatctgat ccttttcttt cgagctttta 3095281 tggtttaatg ttttatgttc gttatgcttt tccatgcgta cacctctgtt taatgatatt 3095341 aattcccatt atactgattg tccaaacggt tgtctaagca tgccgacgca aaaaatgaat 3095401 cagttaggtt ttaccatttg atcaggaggg tatatacttc tgttgataac gcttttaaag 3095461 gggagaagaa aagtggatac gatcaaggtt ggaatattag gatacggatt gtccggttct 3095521 gtttttcacg ggccgctgct ggatgttctg gatgaatatc aaatcagcaa aatcatgaca 3095581 tcacggacag aagaagtgaa acgggatttt ccagatgctg aggttgtaca tgagcttgaa 3095641 gaaatcacaa atgaccctgc cattgagctt gtcattgtca ccaccccgag cggccttcat 3095701 tacgagcata ctatggcatg catacaggcc ggaaaacatg ttgtgatgga aaaaccaatg 3095761 acagcaacgg ccgaagaggg ggaaacatta aaaagggctg ccgatgaaaa aggcgtatta 3095821 ttaagcgtat atcataaccg acgctgggat aacgattttt taacgattaa aaagctgatc 3095881 tctgagggat cccttgaaga tatcaataca tatcaagttt cctataaccg ctacagacct 3095941 gaagttcaag cgcggtggcg ggaaaaagaa ggcactgcca ctggtacgct gtatgatctc 3096001 ggctcccaca tcatagacca aaccctgcat ttgtttggga tgcctaaagc cgtgactgca 3096061 aacgtgatgg cccagcggga aaatgccgaa acggttgact attttcattt aaccctggat 3096121 tatggcaagc ttcaagccat tctatacgga ggatcaatcg ttccggcaaa cggacctcgt 3096181 tatcaaatcc atggaaaaga ttctagcttt atcaaatatg gaattgacgg acaggaagac 3096241 gcactcagag cgggaagaaa accagaggat gacagctggg gtgcggatgt tccggagttt 3096301 tacggaaagc ttacaaccat tcgtggctcc gacaaaaaaa cagaaacgat tccatcagta 3096361 aatggctcct accttactta ttaccgtaaa atagcggaaa gcatacgaga aggtgctgcg 3096421 ctgccagtca ctgctgagga aggtattaat gtcatccgca tcattgaagc cgcgatggaa 3096481 agcagtaaag agaaacgaac cattatgctg gagcactaaa acaaaagcct ccccaaataa 3096541 ggggaggctt tttcattaga atgtttttcc tgcttctttc gcacgcgcaa tcgcgtcttc 3096601 tttgatttgc tgtgctttat caggctccgc attatgtccc tctacgaaaa tgccatcgaa 3096661 tgatggtacg ccgaagaagt tcatcatgat gccgatgtag cggtgcccca tttccatctc 3096721 agccgcaggg ccttctgaat agtagccgcc gcgcgcttgg atatgaattg cttttttatc 3096781 agttaacaag ccgacaggac cttgttctgt gtatttgaat gattttcctg caacagcaac 3096841 agaatcgaga tacgctttca tcactggcgg gaatgagaag ttccataaag gagtaacaaa 3096901 tacgtactta tcagctgatg caaattgatc gctaagctct cccaaacggc ctactttcgc 3096961 tttttcgctt tcagaaagct cttcaaagcc tgtacctgac tgaagctttc cccatccgct 3097021 aaatacatct gcgtcaatgt gcggaatgtt ttctttgtac aaatcgatat gtacaacttc 3097081 atcatttgga ttcgcttctt tgtaagattc gataaatgct ttacctgttg ccatactgta 3097141 cgaagttgct tcgtcatgtg gatgagcagt gatatataat acttttgcca tttttaccag 3097201 ccctttcgtt tttaaaaatc acacatcaat tattatcata cagatgcata atgattattc 3097261 tgtctctctt agactttatt atagagacaa agaaatttac tttcaagtaa aacatctcga 3097321 attaaagatt atttaacttt cccaaacagc ttacttttca aaagctgttc tcaagccgga 3097381 atacagcgcg gacaattctt tactgatccg aggataatga gggacatgcg gcacttgaat 3097441 atccgcaggc atccttttca tgataaagga ttgctcagcc tgttcaaaaa acgcccgcag 3097501 ctggttgatc tcttcatcag aaaacggagc agacggacgg cggtgagctt gcgccgagag 3097561 caaatagtac cctaagtgct gagcaccgga aatggcaggc cagagcgcat ccgcattcgc 3097621 gtgaggaaac tcgccaagcg ccttgtcata cgcatcccga agcctgacaa gactcaccct 3097681 taacttgtgt tcgtcggcaa tttgcccggt taacagtttc tccataaact gcccttccag 3097741 ccggatgaca ttccgcacaa gttctggcag ccgcttggtt gaaaaccgcc gccacaaaag 3097801 cattgttccc aacagcccga tcacgctgcc gacagctaca tcagtcagcc tcgctatcat 3097861 aaaataaccg gcgcccgccc cgccatgcat actttctgtg ataacaagcg catttgcggt 3097921 taaaaaggga acagccagcg cataattgcg gacgatcagc atctcaagaa gacattgcag 3097981 cgctgcaata caaaacgcaa tataaacacc gcccggctta aaaaacagga ttgcgcctgc 3098041 cagtataaca ccgatcaccg ttccggccga acgctgaata gccctgtgaa gcgtaaaaac 3098101 aacagtagtg ccaagcatga ccgctgctgc cgaaagcgga atccaatagg agcgtgcaaa 3098161 gccgaatgcg agggcaaaca tatcggcggc aaacagaaca attccgtact ttaacgctct 3098221 aatcaaaact ggagacttcc agtcaaaggc atttctcaaa aagtaaaaag aggatggcag 3098281 gcggcttggt tccccgtcaa gctgcttatc aaaacgtcct gaagcgatat acaaaacctc 3098341 attgatttct tcaaacagct tccgcctagg ctcagattca ttttcattaa tctgaaacgt 3098401 attgaaaacc cgtgcattcg caagcatatc tccggtttgg cgaagtgcct tttcaatctg 3098461 cgcggtctct ctgtccggcg tttcagctga aaaatgaata atggcaataa atatgtcgtc 3098521 agctttctca aggaggcgaa aaaatcgttc atcatgccgc gattttttcc gtctgttccc 3098581 tttcccaaga accgtttggc gggctgttct aagcatgagc accgtctgat gctgtgcgtt 3098641 atgaaaacct ggcgttccga cggctgaaag acatgcagcc agctgatgat atgttttttg 3098701 cagcaccgct ccctccggtc catgtttgtt ccataaccag ccgattaaag cgatacccat 3098761 ggcgaaaatg ccgccgagaa acgtcagtcc cgctctgaac agcgcttgtg aaggatcggc 3098821 cggcagcccg gaactgacta aaaaggcaag gacaaaaaac atcggcgcag ggccttgaat 3098881 gccgagcgcg ctaaaaataa acatcgccgc tgcaccgatc agccccaaaa cagccgccat 3098941 catccaaagc atcccggaca aaagcgtccc taaaccaaat gagagggcga tcccaataga 3099001 aaccaagagc agcttcaagg cgcgcttttt gtacgattca ccgcccgcat ataaataaac 3099061 aaagcctccg atacttgcaa ttaatccgta atccgtgtga cctgccaatg caccgaccag 3099121 cacaggaaac cctgaagcga aacctgatcc gatagccttt ttccaaggaa atggatttgc 3099181 atgaatgcga aaggcatcct tcacgatagg catgattctt tgattgttcg cagcagtttt 3099241 gttcatttga caaaatcctt ttcaatgaat gtgtagaact tttccagttt cttcgcttta 3099301 gtatgcccaa aaacgcggtt agcttctcaa ttggtgcgca cgataaaaaa acagagactt 3099361 ataccgtctc tgcttcatta catcagttta ttataaaagc ggcacctgtc aggactgttt 3099421 tgtccttctg ccttccttca agagcaggtg aataaaaaat aaaggataaa tcaatagata 3099481 cccattaaac agccaccaca caagatcaaa gtcactgctg aatgtccaga atgatagcgc 3099541 ctgcagacct gaacaacagg tcagcacaag agaaatcagc gccatcagct tccagtcagc 3099601 acgattcacc cgctgtaggt acaagctgta caaccctgtg acagaaatca ggatatccag 3099661 cggaaaaaaa gaccagttcc aagcgatcat aaacggatgg tcatgatgtt taaaagccca 3099721 gctttccggt atgagcgaaa atccggctga cagccagtac aagataaaac cgatatcagt 3099781 cacgagaaaa aacagcttca tatatctcat ttgtactgcc cgcttttatg taccggctca 3099841 gacaccgcaa catgctcgat caggtttaaa gacacaacac cggcaataat caatccaatt 3099901 gaaatgactt tcatgacact cacatgttct tgaaaaaaca aaaaaccaac gactgtaatc 3099961 aagacaattc ccatccctga ccatacagca taagcaactg atacatcaat ggatttaagc 3100021 gtaagcgtca gaaagaaaag actccctcca taaaagaaaa tcaacagcaa actgggaata 3100081 agctttgtaa aaccagacga tagcttcatg ctgacagttc ccgcaacctc aaacaaaatc 3100141 gccaagcata gaaacaccca attcatgtgg catcagcctc ctcatcagct gttataccgt 3100201 taaacaaaac atctacaatt gattcaagta cctctcctgt cgtgaactga tgtttcagcg 3100261 gatattcagg gtcatacact tgattgatgc tccctatata catgtgaaca aacaggtccg 3100321 gattgatgtt tctgattctc ttttgctgtt tgcactcatt taataatgct aggacaatcg 3100381 cccattcttc cttaataaac gcgtctaatg taagccacgc atcgtaatgg tatttcttta 3100441 gttcatttaa taatcccatg ttcagcagtt ccatcccctg cggaaggctg atcagcattt 3100501 gtttcacctt ttcgagcaca tttaaacttt cattttcata gatgtctctt tctatttgct 3100561 tcatttcagc tataaattgt tcgacaaccg cctcaacaag ctgatcttta gatgaataat 3100621 atgcatagag cgtccgcttg ctcgttccca gcgctgccgc caaatcattc atcgtaaatg 3100681 aaaatccttt ctgcttgatc agccggaagg tttccgccag aattctttta tccatattaa 3100741 tcccccgctt tcggtaccaa gaaaactatt tcggtaccaa tattatacgg cagaaattta 3100801 tggaaatcaa caatatataa aaaaacctct cctattggga gaggtttaaa agacactgcg 3100861 gaccaaaccg ccgtccgccc gaagtgccgc gccattgatc gcagaggaaa gcggactgct 3100921 taaaaatgta acgaagtggg cgatttcttc cggacggatc agtctttgaa taatagatgt 3100981 cggccggttt tctttcataa aacgtgcctc agcttcttga acagtcaggt tttcaccagg 3101041 atacagcgag ttcagcatgg tttccacacc ctctgttaag gtagagcccg gcatgacggt 3101101 gttgactgtg acattcgtgc cggttgccag ctccgccaaa ctgcgggaaa tggacagctg 3101161 catcgttttt gtcgcactgt aatgggccat ttcctgtgac ggcataatcg ccgcttcact 3101221 ggcaatgaaa atcacacgcc cttctttttt ctctatcatg ttatgcaaat acctgcgtgt 3101281 cagccttaca ccgctcataa tattcacttc aaaaaaacga aaccattcat cgtcgggaat 3101341 atcaaagtac tccgccggtt caaaaatccc taaattgttg accaaaatat caacctctgg 3101401 atatgcctga aacagctcat tgcagccttc ttctgttccc aaatcaaatg cagccggata 3101461 aagaaccgct tcagcatgtt gtgttttcag ttcatctatc gtttgattca ctttctcttc 3101521 ccggcgtccg ttaatgatca ctgccgcacc ttcttcagct aacgaagagg caatagcttt 3101581 tccgatccct gatgtcgaac cggtcaccag tgcggttttt ccttgtaaat tcagcttcat 3101641 tattcatccc tccgtttttg attcctctta tttattgaca gaaatctgat tggtgaaaca 3101701 tctgctctgc aatcagtatg aaacagctgg gattgaaatg gaagtacgca ctttttggtg 3101761 cctgtggttt ggagaaaaaa taaagcagaa cctcttaaga ggttctgctt tattgtcagt 3101821 atgtatggag acggtgggag tcgaacccac gtccagaaac atcgattact taagcgtcta 3101881 cgagcgtagc ctgcatattt atggtttcac tcatcttctt gcctgcgggc gggccttccg 3101941 agagctagtc tgttcatctc ttcttacgtt ctcagacggg aacgcaagcg tagcctactt 3102001 ggatgtgctc ttcacagaca cataggcaat gtcaggaaga gctcgctgcg cttattaggc 3102061 agctaatgct acgttttggt taaaactgtt agttttgcca gttatattta agtgcgtgtt 3102121 tacgagatcg cctctcggct cgcagctcaa gctcgatcca tccctgtcga atccgtaacg 3102181 tccccttggt ataagggaaa tacgggagaa aatatcaagc tctcactcaa actggctata 3102241 gtcttattat aacatgatca cggctctttt caattgtcaa atccttcaaa tgaatggcgt 3102301 cgtgatctga tcgtgaacac agtatagcac aggcctgatt ttcgaatcaa gcactatgcc 3102361 tttagaagcc tttttgactg tctctgaacg ctctttcgat ttcccgcttc gcgtccttgc 3102421 gcttcagatc ttcccgtttg tcatagttct tcttcccttt tccaaggccg agaagcactt 3102481 tggcaaagcc gttttttaaa tacagcttca gcggaacgag agaatagcct ttttcctttg 3102541 ttaacccgat cagcttatta atctccttgc ggtgcattaa cagctttctt gtccggagcg 3102601 gatcgtggtt atagcggttt ccctgctcat atgggctgac gtgcatattg tggagaaaca 3102661 cttctccccg ttcgattttg gcgaaggaat ccttaaggtt tacgcggccg gcgcgaatcg 3102721 atttgatttc ggttccttgc agaacgatgc ctgtttcata ggtttcttct ataaaataat 3102781 cgtggttggc tttcttattt tgagataata cttttcctga cccttttggc atgccagaac 3102841 ctcctctctc taaggaaaaa ctgtccacct tttgcgatac gctctatttt accaaatgtc 3102901 acgtaccgct acaatgaaaa gctgtttccg aaagaaagca aatagagcgc tgcggcccta 3102961 tttgctggtt gagctgctat ttcttctttt tccgtttctg tttcggagca ttctggaagc 3103021 cgcgtttttt ctttttcttc ttcggcttag tgaaccactc ccctttttcc tcagacggag 3103081 ctggagaaac aggtgtattg gtgctttgaa cacgttttct ggcaggcttt ccgcgttttc 3103141 tgctccggct gctgtccaat tctctcggac gccgcggagt gcctttcatg ccgacaattt 3103201 caaagtcgat attgcgctca tctttattga catcgacaac cttgactgtg atttcatccc 3103261 cgatgcggaa gacgttgcct gtccgctcgc caatcattgc gaaatgctgt tcgtcaaagc 3103321 ggtagtagtc atctgtcata aagctgacat ggacgagtcc ttcaattgta ttcggcagct 3103381 cgacgaacat tccgaagttt gtcacagagc tgatcatgcc gtcaaactct tcaccgattt 3103441 tatcaagcat gtattccgct tttttcagat catccgtctc acgctcggcg tcaactgcac 3103501 ggcgctccat agatgatgta tgttcggcga tatccggcag gcgttcagcc cacttttcct 3103561 gtgtcgcttc atcgaccttg ccgttgatca aatacgttcg gatcagacgg tgaacgatta 3103621 agtccgggta acggcggatc ggtgatgtga aatgcgtata gaattccgtt gacagaccga 3103681 agtgccccaa gctttgcggg tcgtatttcg cctgtttcat cgaacggagc ataacagtag 3103741 atataaccgt ttcctctggt ctgtcacgca cagcgtccag aatgctttgc agcgcgcgcg 3103801 gatgaatatt ccccgccgtt cctttcacca catagccaaa tgtcgtcaca aattctaaaa 3103861 acttttgcag cttttcagca ttcggctctt cgtgaatccg gtatataaac gggacattca 3103921 tccaatggaa atgctccgca actgtttcgt ttgctacaag cataaattct tcaatcagct 3103981 tctcggcgac agagcgttct ctgatcacaa cgtctttaac cgctccttcg tcatcaacaa 3104041 gcacctttgc ttctttgaaa tcaaagtcaa cggcgccgcg gtccatccgc ttatcgcgca 3104101 gaatttgagc cagacgctcc atgtctttga acatcggaac aagaggctcg tatttttgtt 3104161 tcagctcttc atcatcatca acaagaattt tattcacatc tgaatatgtc attctttccg 3104221 ttgttttgat gacactttgg aagatctcgt gctctgtcac ctgtccctga ctgttaattg 3104281 tcatttcaca agaaagcgtc aggcggtcaa cctttggatt taaggagcag atgccgtttg 3104341 acaatctgtg cggaatcatc gggatgacac ggtcaaccag atacacactt gtccctcttt 3104401 caagcgcttc tttgtcaatc ggcgagtttt cggttacgta atggctgaca tcagctatgt 3104461 gaacgccaag cttgtagctt ccatcatcaa gcttcgtcac ggtaactgca tcatccaaat 3104521 ccttcgcatc cgcaccatca atggtgacaa tcacctggtc acggagatca cggcggtctt 3104581 tcagatcttt ttcatcaatc gtgtcaggcg tacttgatgc ctgttccatc gcgtcagctg 3104641 gaaattctcc cggcaggccg tgcttatgaa tgaccgataa aatatcaatg cccgggtcgt 3104701 ttttgtggcc gagaatggtt tcaacctcac cctctgcgtt catgcggcct tcaggatagc 3104761 tcgtcagctt gacaacaacc ttatgccctt ccgcagctcc atttttccca tttttcggaa 3104821 tgaagatgtc actcgtgatt tttttgtcgt ccggaatgac aaagccgaag tttctcgttt 3104881 ctgtatacgt gccgacaacc cgctgaatcg ctctttctaa aatccgtatg acggttcctt 3104941 cctgcctgga gccgcttgat tgtgagttca gacgcaccat gacgatatcg ccgttcattg 3105001 ccgtatttag ctcattaggc ggaataaaca catcacttaa cgacgtatcc tcaggcagca 3105061 aaaaggcgaa tcctttcgca tgggctgaaa tctttccttt tattaaattc atcttctccg 3105121 gaatgccgta gcggtcgctt ctcgtccgta cgataagccc tttttcttcc aaggcgacta 3105181 acgctttgac gagctcttta aactcctcgg cttccgtaat atttaacatc tcctcaagtt 3105241 cctgaacggt cagaggtttg tacgcctctt ccttcataaa cgagagaagc ttttccataa 3105301 atgcttcttt ttccattatc cgacctcctg ttgattacca atcgagcttc tctaaaaatt 3105361 catacacatc ctgatggacg aggtcacgtt ctttgtcgag tgtaatgaca tgccctgatt 3105421 cctcgtacca tttcagctgt ttatcatcag tttccacttc gttgtaaata atattggcgc 3105481 tttcggtatt aatcatgtgg tcatgacggg cctgcaccac aaatgtcggt gaataaatca 3105541 tatcgacatt attccgcaca tcagcaatta agtcttgcag cgccttgagg gtattcatcg 3105601 gcgttttttc gaattctttc atttcctctt caatttgctc cgggcttttc ccctcaaact 3105661 ttttgtaatt gcgagcgtat gaaagaacgc cttgatacat gacctcttca ctcttaatat 3105721 gcatcggtgc gcacattggg acaattccct ttatgggtac agtgtaaccc aatttcagcg 3105781 aaaaaacccc gccaagcgac agtccgcagg cagcaatgct ctcataacct tcagatttta 3105841 aatattcata gccatccatt acgtttttcc accagtcttc gggccccgta tgtacaagtt 3105901 cttcaggcgg gacgccatgt ccttcatatt gaggcgcgtg gcacgtatag ccgcgttcat 3105961 tcaaatatcg tcccagcatc cttacatccg ctgtatttcc tgtaaagcca tgcagcaaaa 3106021 gcaccgcttt gtctccgcct ttaaatgtaa atggttttgg tgtcacaact ttcatgctca 3106081 tgtctccctt tctatctgca cgatcatttt agttttccac agtttaatca gaaaaaaacg 3106141 ttttgaatat catccagaaa cgtgaaaaag gcctgacttc acatcagacc ttatacaaac 3106201 attgccctat aggatataag caagcgcaat cgttaacacg aaaaacaaga ctgccagcac 3106261 taccgtaatg cggtgcaaaa ttaaatcaag acctcttgct ttttgtttcc cgaagagctg 3106321 ctccgctccg cctgaaatcg caccagataa tccggcactt ttactggatt gaagcaaaac 3106381 gacaataata agtgcaatgc tgacgataac caataaggta atcaaaactg cgtgcatccc 3106441 atacacctcc agactcactg gctacattac ttctatttta catgaaaagg gttggcatgt 3106501 cacgctgtat cagacgccaa aaggccggat aagacgtttt atcttggtta ccctattcat 3106561 atgaaaaggt caaaggagaa aagcgatgcc gcttatcagc atagacagca ggaaacatct 3106621 tttttatgaa gaatatggac agggaatccc tatcattttt atccacccgc cgggcatggg 3106681 acgaaaggtt ttttattatc agcgccttct atccaagcat ttcagggtga tttttccgga 3106741 tttaagtggc cacggtgata gtgatcacat cgatcagcca gcgtctattt cctattacgc 3106801 aaacgagatc gcgcaattca tggacgcttt gcacattgat aaagctgtgt tattcgggta 3106861 ttctgccgga ggcttaatcg cgcagcatat cggcttcacc cgcccggaca aagtgtcaca 3106921 ccttattctg tccggcgcct accccgctgt tcataacgta atcggccaga agctgcacaa 3106981 actgggaatg tatctgcttg aaaaaaaccc cggtttgctc atgaaaatcc tcgctggcag 3107041 ccacacaaaa gacagacagc ttcgcagcat attaacagac catatgaaaa aagcagacca 3107101 ggcccattgg catcagtatt atctggattc gcttggctac aactgcattg aacagctgcc 3107161 ccgcctagaa atgccaatgc tgtttatgta tggcggcctg cgggactgga cctttacaaa 3107221 cgcaggctat taccgaagat cgtgcagaca tgccgaattt ttcagattgg aatatcaggg 3107281 acatcaattg ccgacaaaac aatggaaaac gtgcaatgag ctggtgacag ggtttgtgct 3107341 gacacatcat tcataggaat agaaaacgct tggcttcctt gcgttttttg ttactttatt 3107401 gacttttgtc aacgaaatca tagtaaaaaa gatcctcaaa tttcaaatta aaatagtgaa 3107461 gcattttacc aatcacaagc tgccccggcc ttctttctcc attcagcacg cggctcagtg 3107521 tggcgggtga gactccgatt tccagcgcaa gctgattaag ggaataatcg ttattaacca 3107581 tatactgcaa gacataatca cgtctaatct gtatcttttc tactggcact ttcctcacct 3107641 tccattcctg aaaaactttt ttctatactt ttacattacg gcttatgtta acttttgtca 3107701 atacatttcc agtctaccta ttccctttag tcaataaaca tactaaaata tgagtaacag 3107761 tgagggacgg ggtgagatat atggaaagct ttggcgaaca attacgggca ttgcgtgaag 3107821 agagaaagtt aacagtcaac cagctggcga cttattcagg cgtaagcgcg gccggcatct 3107881 ccagaatcga aaacggaaaa cggggcgttc ccaaacctgc caccatcaaa aaactggcag 3107941 aggccttaaa aattccttat gaggggctta tgtacaaggc tggttacatc gaagaagtgc 3108001 atgaagccag ggccccttat gaaacgaagt gcaagctgct tgaaaaagcg gaggcctatg 3108061 acctgaaaaa ccttgcgctt cttgagaacg aaaagtggca atatctcaat aaagaagatt 3108121 tgctcatgct ggatcattat ttttcgttta tttcagatga agcgaaaaaa cggtctgctg 3108181 atgactgact cttgatagaa atgtgaggcg atagaccatg tcaccgttcg gacagcaatt 3108241 acgggagctg cgccgcgccc gcaaactgac agtgaatcag cttgcggtgt actcaggcat 3108301 cagctcggcc accatttcaa aaattgaaaa cggcaaacgc gggacgccaa aacccgccac 3108361 gattaaaaaa ctggcagccg tcctgaaagt gccgtacgaa aacctaatgg ccgccgcagg 3108421 ccatattcag gcctttcctg aagaaatccg cgaagcatct gaaggctatc aatccgttta 3108481 tgaaatttac cagacggctg tcacacgcgg agcggagcac ctcccgattt tcaatagtca 3108541 aaaatgggaa catctctcaa agcaggatat tgaaaatctc agcaaatact tcgatttttt 3108601 gtcttcagaa gcaaaaaaac gcgcctcttc ctcataatcc cctgtttctc tttctatatt 3108661 ttatcaatca cgcttgcatg ccctccctcg ttatttgcgt tataatagtg acagacgagg 3108721 tgaaaagtat gaaccaatca gaaatgtgtc ctagatttga aaaagcagtc gacatcttaa 3108781 gtaaacgctg ggtcgcttta atcgtatttc agctcttgaa cgggtcgcag cgatttagcg 3108841 aaattgaagc agcacttcca aatctaagcg gcagagttct gtcagaacgg ctgaaagaac 3108901 ttgagcttga aggagtagtg aagcgggatg tcatccctga aactccggtt cgcatcgaat 3108961 attcattgac tgataaagga aaggcactag cacccatatt aggtgagatt tctaaatggg 3109021 cgactgaatg gattgaccct tcctttcttg actaattgct aaaatggttc tgatctcaaa 3109081 gacgagaaaa gaaccgtttt ttattttcca ggtgaaaaaa agatatctca gccgatatat 3109141 agtacatcca cacattacgt ttttaaagga gaccactata tgcgactgac gatttcccgc 3109201 aaattcagcc tggtattttt gacactgatc ctgatcaatt tacttgtagg cggaataggc 3109261 gttcttaata tgcagcatat cattcaaaaa acagatgaaa tcaacacaaa atggattgac 3109321 ggcatcaaag gaatcacttc aattaattat gtaaccgagc acctgtcttc taaagaaaag 3109381 gactttctga tttatacaga caaaagtaaa atggatacac ttgatcaaga aatgaatcaa 3109441 atcatggaag acattaacca aaagctcgat aactacgaaa aaacgatctc cactgataaa 3109501 gagcagaaac tgttcgagca gcttcaaact aaagtgaata cctatatgga tattcatgcg 3109561 caaattatcg aaagcggccg cacgaatgac atggacaaag caagaggttt attggttcag 3109621 actgaggcca gctttgagga tatgaaaaaa acaatcactc agcttgttga cttaaatcaa 3109681 gaaggcagca acacagcggt aaaagaaacg aaggccgtct atcataaagg gctcatttac 3109741 actgctttgc ttgtggcagc atcaatcctc atcagcattt tcatctggct ttatatcacg 3109801 cgaaacattg taaagcctat cattcgcatg aaggaatctg ccaatcatat tgccgaaggc 3109861 gatttgtcga acgatatgga ggccctcaac tcaaaagacg agctgggtga tctgaatgaa 3109921 gcgctgcaaa aaatggtagg gaatctgaga gatattgtcg gatattctaa agacatatca 3109981 agccgggttc tttcttcttc acaggtgctt gcaaccgcaa cgaatgaaac aagatccggc 3110041 agcaaacata ttaccgagac gatgaacgaa atggctgagg gctctgaaca gcaggcccaa 3110101 gacgcggtga cgattgccga atcgatgaat gagtttaccg aaagcattga taaagcctat 3110161 aatcacggca tcacaatcag cgatacgtct caaaacgttc tcgaactcgc ggtaagcggg 3110221 aacgaaaata tggctacgtc attacagcaa atgaaaacca tccatcatat tgttgaagaa 3110281 gccgtgcata aagtgagatc actggaacag cattctcagg atattaacaa gctcgttcag 3110341 gtcatcaacg ggattgccga gcagacgaat ttgctgtccc ttaacgccgc gattgaagct 3110401 gcccgcgctg gagaaagcgg caaaggcttc gccgttgtgg cagaggaggt cagaaagctg 3110461 gctgacggcg tttctgattc cgtgcaggac attacccgga ttgtaaacgg gacacagcag 3110521 gagatccaca ctgtcattac gtacttggaa agcagcttta cagaagtcga aaaaggaacg 3110581 gaaaacctga cagacaccgg acaggctatg cagcatatca aacaatccgt cacccatgtt 3110641 gcagacagca ttaaggaagt aacggatggc ttgaagcagt taacaaacca atcgattacc 3110701 atcaatcaat cgattgaaaa tatcgcttct gtatccgaag agtctgccgc cggcattgaa 3110761 gaaacatttt caattaccga gcaatccgcc cattcgatgg atcaagtgct tctaaatgct 3110821 gaagagcttg agcagctggc caatgagctt aatgagaaga tgggtcagtt tacgatttaa 3110881 agagaaaaaa gaggctggac tccagcctct ttttctattc tatgcagctg attgaacatg 3110941 tttcgccccg gttctttttt tcttcaccgg acttaatgcc cgctccagcc aagccatgag 3111001 caaatccgcc cctaccgcca tcaccgcagt tggtatcgct ccggctagaa taatcgcagt 3111061 tccgtttgtt gcgtttgagc cgcgtacgat catgtcccca aggcctccgg caccgacaaa 3111121 tgtgccgatc gctgtaattc cgatggcaat gacgagagcc gtgcgaaggc ccgccataat 3111181 gacagaaagt gcgagcggga gctcaaccat tctgagcact tggaatttcg tcatgcccat 3111241 tgcttttcca gattctaagt aggcatgttc aatactgata atgcctgtgt acgtgtttcg 3111301 aataatcggc agcagggaat acagaaataa tgatagaatc acggtatttg cgccgagccc 3111361 cataacaagc attaagacgg ccagcatagc gagcgccggg attgtttgaa taacgtttgt 3111421 tacggcaaac acccaggctg acaaacggcg aaaatgcgcg atgaggattc cggccggaac 3111481 cccgacgaca gcggcaaata aaacgccgta agccgacatg agaaagtggc ggccgaattc 3111541 atccatgacg taactgccat tctgcgcgta atacgtcatt aactgttcaa gcacgttcat 3111601 tgacctcttc cccctttcac gattcgaaat agcgatgttt ttctaaatat tccttggcaa 3111661 cgacagacgg ttctttgaga ttgccgtcga cttcatagtt aagctcctgc atcgtggctg 3111721 tgtcgatttt tccgagcatt ttcttgatga tgccttcaag ttcaggatgt tctttgagca 3111781 ccttttccgg aacaaccgga gagcagtcgt acggcgggaa aaattgttta tcatccttta 3111841 gcattttgag accataggac ttgattcttc catcggttga atacgcaagc acaatgtcca 3111901 tttttccgct tttcaccgcg tcgtacacaa ggccgatctg catcggatac gtgccgccga 3111961 atgtcatgcc gtaggttttc gtaaaatcct gatagccgtt tcctttgagc ttcatccaat 3112021 agttatcaac gcccagcttt aattgcggcg cccatttttt aacgtctgat acggtctcta 3112081 aatggtattg gtcggccagc tccttgctga ctgtaaaggc atatgtatta tcaaacccgt 3112141 aggagtcata ccactttaaa tcatatcttt ttttaaactc ccgctgagta agcgccagcg 3112201 ctttgtccgg atctttttca ggttccattc tcaacgtgcc tgtcagcgcg tctcccgtat 3112261 atcttgtggc cgcaatgtcg atttccccgt tcattaaagc ctgctgctgc accgcgttgg 3112321 agccaagatt tttaatcgtt gttgttttga gatcagtatg gtgttcgatc aactggccaa 3112381 gcatgctggc gatgatttct gattcgctca tgctttgcgc gccgatttta atggtctggt 3112441 ctgcagcagc gctgagacca ggaagcgaac agccgctcag cgtcagcgtt gccgcaagtg 3112501 ctaaacctat cattaatttg agatattttc ttttcatgag ccgcctcctt atgacaattc 3112561 cttcaatctc tgcatgccgg caggtgtcag ttttcgttca gcaactgcca gcacataatc 3112621 aatcacaatt gccaatatcg tgacaggtac cgcgcccccg atgatatatt ccggctgata 3112681 taaattcagt ccgataaaaa tgtaatcacc caatccgccg cctccgataa aggaagcaag 3112741 cgtggcccag ccgattaagt aaatcgtcga tgttctgatt cccgccatga tcactggtgc 3112801 ggcaagcggc agctccacca agcggacttg ttcagccggc gtcattccta ttcctttacc 3112861 agactcgagc agatttttgt tgacgccgcg aatgccggta tacgtgttgc gaagaatcgg 3112921 caatacggaa tagaaaaaca aagccacaat ggccggaacc ttccctacac caaggagcgg 3112981 gataaaaaaa gcgaggatgg ccagactcgg cagcgtctga atgatattga caatgccgat 3113041 aatggtgccg gctccttttt tcattctggt aagcacaacc ccgaggggga cggcaaccag 3113101 cacacctaag atcacagcaa tgagcgatat cgtaatatgc tcgtatgttt tataaagaag 3113161 ctctccccca ttggtttgca aaaattgaac aatatgatgc atgacttatc gcccctccct 3113221 atgacaatgc tgcgagctgc ttttcttctc cccagaggga gtcatacacg atgtcgacca 3113281 gacttgccct cgtcacaatt ccgatcaggc gtcggtcttc atccacaacg ggaacatatt 3113341 tgacaccccg ttttaaaatt ttgcggaccg tgtcgcgcag cagtgtgccg cccagtactg 3113401 tgtatatatc ttcatgtaaa acttcactga cgagattggc ctttttccgg cattgatcaa 3113461 tgatttcaac atcgacatag ccttgcagaa cgcgctcgtc attgacgacc agcaatgaat 3113521 cgacccgttc ctgcctcatc agctgaatgg cctcagaaag cgttttatcc gcggtgatcg 3113581 ttacaggctg tgtgttcata atctggtcaa cccgttcaac atccgggctg gatgactgaa 3113641 tcagccgctc cttgccgata aattcctcaa caaattcgtc tgccggattt cttaaaatgt 3113701 catcgggcgt tccaacttga acgatttctc ccgcttttaa aatcacaatc cggtctgcca 3113761 gcttaatcgc ttcatccata tcgtgggtaa caaatacgat ggttttatgt aaggtttttt 3113821 gcagtttttt aaattcttcc tggagggaat ccctcgtaat cgggtcgagt gccccaaacg 3113881 gttcatccat taagataagc ggcggctccg cggcaagtgc ccgtaataca ccaattcgct 3113941 gctgctgccc cccgcttaat tcatgagggt aacggtctac atattctggc cccatatcga 3114001 ccaattttaa aagctcacgc gcccgctctt tccgctgctg ctccggccat ttcagcagtt 3114061 ttgggacgag tgagatattc tgctgaatgg tcatatgggg aaacaggccg atctgctgaa 3114121 tcacatagcc aattttgcgc ctgagctcta caggatcctg gtccatgatg ttttcgccgt 3114181 caatgaaaat cttcccggcg gaaggctcaa ttaatcggtt aatcattttc attgttgtcg 3114241 tttttccgca gccgctcggc ccgataaagc agataaattc gccttttgca atcttaagat 3114301 ttacgttgtt cacggctttt ttgccgccct tgtatgtttt cgagacattt tctaatgtca 3114361 gcaaacatcg cacctccaaa attaagttta ttcaatttgt tcagtttaaa tttaattttt 3114421 cagacaattg aatgcttccc attatagaat aaagtttata aaataaaaag tttacaattt 3114481 gttcatatta tttataaagt atgtgtaaac gctgatttac ccgcattgac gtgtgttgat 3114541 ctccttattg ctccaatttc ctgccaaatt ctcttttgac agcattttcg ccgtatcaaa 3114601 aatgtggtat attgacatcg gaattgttag ctgaaaggat gaaaccgttg gagaaagatc 3114661 cgttaacgat cattgaacaa gccgaggacc attttataga aagaatcgcg gaaaacatgc 3114721 atgcatttgg aatgccctct accgtcggac gagtgctggg cattatttat atgaatcgaa 3114781 aaccgatgac gcttacggaa ttatctgagg ccaccggcat gagtaaaaca cgtatgagcc 3114841 aggtagtgcg ggaaatgctt gatgccaaca ttgccgagaa ggtattcgaa aaaggcgtgc 3114901 gaaaagattt atatgaggtt gagcaggact actatcaaac atttatcacg ctgttttcag 3114961 ccacctggag caaagtcgtc agcaaaaaca aaatgatgca taaaaaactc aatcgggagc 3115021 tgcttagcgt gttggatgaa gagcttactc ctgaagcgga agaaaaagtg aatgagctgc 3115081 tgaaggaatt aaaggaatgg ctcgattatt ataattggct cagccgtttg attgagtttt 3115141 ttgagagcga agacattttt aaatatgtgc cgaagccgta aaaagttccc aaattcaatt 3115201 ctgggaactt ttttaagtcc aatccaaatg gttgaatatc aaacttcaag aaaacaaaca 3115261 aaataatgca taatttacat taatttatta attatccatt ttttgttgat tattctgact 3115321 agctattata taatcttttt gaaatgatta tattagctta gaggaggtaa tctacatcaa 3115381 aaaaaaggga attattactg taatgactat atgtttccta ttattttctt cttattactt 3115441 tagcaatatt tcacctcaga atccactgtt caaaaaaaat tttttgcaac aattgtctcc 3115501 ccaaggcttt ggcttttata gtaaaagccc tacagaagaa aacatttcat ttcacacaaa 3115561 agaaaattta aagttaccta atgcacttcc caataatttt tttgggataa aaagagaagg 3115621 aagagttcag gcaatagaat taggcaaaat tgtagagaat atcgatccaa agaattggaa 3115681 aacttgtgaa aacaacaact cctgcacaaa tttagagaaa caaataaagc ctattaaggt 3115741 tataaaaaat gaagattata tacatcttag caaaggagaa tacctaatat atcgccaaaa 3115801 accactctca tggtattgga tagactttaa gcaaactacc tcttttgaaa gaaaggtgct 3115861 aaaaataaaa atagtatgaa gatattaaat agtttagaag gttatattga cacctataat 3115921 ccatggaaaa atacatatgc actttttaga agtttacttg gtttctcaac attactagta 3115981 ctattattca atagtactga tattttattt agttatagtg caaataatgt cacatgtgaa 3116041 aatgtctata tccctaccgc tttttgtttt gctaaagaat atagtatcaa ttttgagatt 3116101 ataagatact taatgatttt tatattaacc ttagtggtta tagggtggag acctagattt 3116161 accggtttat ttcactggta tatttgctat agtattcaaa cttcagcttt aactatcgat 3116221 ggtggagagc aaattgcaac tgttctttct tttcttatat tacctgttac attattagat 3116281 tcaaggcgaa atcattggaa tataaagaaa aacaataatg aatctttcac aaagaagaca 3116341 gtattgtttt atataatgac aataattaaa attcaagttt ttatcattta tttaaacgca 3116401 gctttagagc gattgaaaaa taaagagtgg gcagaaggaa cagcaattta ctatttcttt 3116461 tctgatccgg tgtttggatt acctgaatat caacttaact taatgaatcc actacttgaa 3116521 agcaatttta ttgttgtcat cacttggtta gtaactattt ttgagttgtt cttagcagca 3116581 agcataattt caaatatcag aataaagaga attgcccttg ttttgggaat attatttcat 3116641 attgggataa tattcagcat tggtattgta agttttggct tgatcatgat atcagcatta 3116701 attatatatc tgcatcctgt acaacaaaat atcactatga attggtgttc tcctttattt 3116761 aaatatatat atgtaaaagg aaagagaaat ttcaaaagaa taggaggtga atcagtcaag 3116821 tttcttacaa aattgtttca tagctaacat ttagataatg gagaaataac ttaatggagg 3116881 tataataatt tgaaaagtaa attacttagg ctattgattg tttccatggt aacgatattg 3116941 gttttttcat tagtaggact ctctaaggag tcaagtacat ctgctaaaga aaaccataca 3117001 ttttctggag aagattactt tagaggactt ttatttggac aaggggaagt tggtaaatta 3117061 atttcaaacg atttggaccc taaactcgta aaagaggcaa atagtacaga aggtaaaaag 3117121 ttagtaaatg atgtagtcaa atttataaaa aaagatcaac cacaatatat ggatgaattg 3117181 aaacaatcga ttgacagcaa agaccctaaa aaactcattg aaaatatgac caaagcagac 3117241 caacttatcc aaaaatatgc taagaaaaat gaaaacgtaa aatactcttc taataaagtt 3117301 actccatctt gtgggcttta tgccgtctgt gtagcagctg gatatttata tgttgtgggc 3117361 gttaacgcag ttgcattaca aacggctgcc gcagtaacaa ctgcagtgtg gaaatacgtt 3117421 gccaaatatt cctcttcagc ttctaataat tctgatttag aagcggctgc tgcaaaaacc 3117481 ctaaaattga ttcatcaata atccattata attgagtgtc ttgcggattg ctccgcaaga 3117541 cactttttca acgtgaaccg tttaattttt tgtaataatg atatgaagct agtgttgaaa 3117601 taactaatgc tagaagaact agcacaatca taataagaat tatatattct cctgtaaaaa 3117661 atgaaagaac agctattata aaaccacaca ctacaagtac tttagaggca aagcgatttc 3117721 ccagtttcca aacagtctca tcttttaatg tccaaggtgt cctcaatcca ataagatggt 3117781 tttgttctgc tagctgcata gaatttccac caataattaa aaagatacca acaccaagcc 3117841 ctattattaa atcaatattc acttcgtatc ctaaacttat caatagagtt gagagttgta 3117901 aaatatataa aaggattaac atattattag aagctaggaa aagcaatgct ttattttttt 3117961 gtgtagactt aatagttaac atataaaaag taagataata aataagcata acaacaggta 3118021 taataaatat tgttaaaggt ttagatacaa ttgcagccgg tttatttcct gaccattgta 3118081 tcggtatttc ttctggaagg tattgatata atataattga agtcaagaaa ctcaaacata 3118141 caataattat ggaaattata tttttcttca taaatcgtta tcccctttat ttataaagtt 3118201 aagcatccaa tttattgagt cttgaagtac tgttgtattt agagagtaat aaataaattg 3118261 tcctttgcga tggtcactta tgacttccgc ttgctttaaa atattcaagt ggtgcgaaat 3118321 actcggtttg ctgatattaa aatgctcagc aatatctccc gcagtcatat cccctccttt 3118381 taacaaatcc aaaatttttc tccttgttgg atctgatata gctttgaaaa cattattcat 3118441 agcgttttct cctttacaaa aaaacattta gacatttaga tatttgtata aatgtattat 3118501 tttcattata acttgaattt ttttaaaaac aaccctcaaa ttggttataa tatctgattt 3118561 ttgtattttt tcaaatactc ggataatccc aacgctggaa aatatgttta acagatacta 3118621 acacatgttg tttatttaaa aaaaccacct ctgttgtatt taaatagagg tggtttttct 3118681 atcagctata ataaaatttc cttttttctt tttaatcggg cttaatgctc gttcaagcca 3118741 gcccatgacc aaatcggcaa tcaccgccat cagagctgtg gggatcgctc ccgctaatat 3118801 aatcgcggtt ccgtttgtgg cgtttgatcc tctgacgatg atgtccccga gaccgccagc 3118861 accgacaaat gtcccgatgg ccgtaatgcc gatcgcaatg acaagcgcgg tgcgcaggcc 3118921 ggccattatg acagaaagcg caagcggaag ctcgaccatc cgcagcactt gaaattttgt 3118981 catccccatt gcttttcccg attcaagata ggcgtgctca atactgataa tccctgtata 3119041 cgtatttctg ataatcggca gaagagaata cagaaataat gacaatatca ccgtattagc 3119101 gcccagcccc atgacaagca tcagcacggc gagcatggcg agagccggga tggtctgaat 3119161 gacattcgtg accgcaaaaa cccatccgct taatcttctg tatctggcta tcaggatgcc 3119221 gagcggaatt ccaacaatgg cggcaaataa aacgccatac accgacatca gaaaatggcg 3119281 gtaaaattcc tgcagcacgt aaccgccgtt ttgcgaatag tatgtgccaa gctgctgtag 3119341 tacttccata tgatccacct cttttcttag tcaaaataat gatgtttctc taaaaattcc 3119401 tttgctacga cagacggctc cttcagcttg ccatccacct cataattaag ttcctgcatc 3119461 gtttccgtgt cgatttgccc aatcagctta ttgatcacac cttcaagttc cggatgctcc 3119521 ttaagcacct tttccggaat caccggtgaa cagtcatacg gcggaaagaa acgcttatcg 3119581 tcttttaaga ttttcagatc atatgcttta atccgtccat ccgttgaata agccaaaacc 3119641 gcatccattt tcccgttttt gactgcgtca tagactagcc cgatctgcat tggataagtt 3119701 gtgccgaact caaagccata tgtgctgaca aagcctttat acccgtcgcc ttttcgtttc 3119761 agccaagcat tgtcgacgcc taatttatat tgggaagcat ttttcttcag gtcagacacg 3119821 gtgttaatat gctccttttc cgcaaacttt tttgttacgg tgaaggcata tgtgttatca 3119881 aagccgtagg aatcaaacca tttataagaa aagcgctttt gaaactcgtt ctgcacaatg 3119941 ttcagcgctt ttttcggatc tttctccgct tccttgccga gggtgcttgt taaatctgtt 3120001 ccggaatagc gcgtggctga aatatcaatg tcaccgccca gcatcgcttg gtgctgaaca 3120061 tagtttgagc cgaggttttt cactaaagca gtattcaaat ctgtatcatg ttcaataagc 3120121 tgcgcgatca tattcgctac aatttctgat tctgtcatgc tctgcgcccc gattttgatc 3120181 gtatcgtcag aagcgccgcc tagacccggc agagagcagc cgcctagcag catgacaaag 3120241 acgagagcaa acgcgccaag ccatttgatt tttgtcattt tcaacagtgc caactcctta 3120301 cgatacttcc ttcatccctt gcaagccttt cggcgtcacc tttcgttctg tcacagccag 3120361 aacataatca ataataattg ccagaattgt gacaggcacg gcaccgccaa tgatatattc 3120421 aggctggtat aggttcagtc cgataaaaat atagtccccg aggccgcctc ccccgataaa 3120481 cgacgcaagt gtcgcccagc caattaggta gatcgttgat gtgcggatcc ccgccatgat 3120541 gatgggaatc gccagcggga tttcaacgag ccgaatctgc tcccagccgg tcatgccaat 3120601 tcctttcccc gattccagga ggtttttatt tacaccttta atgccggtat acgtattgcg 3120661 caggatcggc agtaccgaat agaaaaataa agcgacaatc gcaggcactt ttcctacgcc 3120721 gagaagcgga ataaaaaagg ctaaaatcgc cagactcggc agggtttgca caatgtttac 3120781 gaaaccgata accgcacctg cgcctttttt cattctggta agagcaacgc cgagcggcac 3120841 tgcaacgata atgcccaata caacggctat gagtgaaata tataaatgct ctcctgtttt 3120901 atacagcagc tctccgccgt tcgtttgcaa aaaagtcatc atttgattca tcttaaaaga 3120961 gctcctcccc tggtcagatc gtcatgagct ggttttcctc gtcgccccaa atggaatcgt 3121021 atacgatatc aacgaggctc gctcttgtca caatccctgc taaatggttc tgttcatcga 3121081 ccaccggaac atacttgatc ccctgcttca aaatttttcg gactgtatcg cgaagaagcg 3121141 cccctttttg aacggtatat atatctgaac ggtatacatc gccaacgatg ctcgcttttt 3121201 tgcggttttg atcaatcatt tccacatcaa catagccctt cagcacgttt tgccggtcca 3121261 caacgagcag cgagtcaaca cgtttttctc tcatcagctg aatcgcctga gaaagcgttt 3121321 tgtccgcaga taccgtcacc ggcgttctgt tcatcatttg ctctacccgc tcgatatccg 3121381 gtcttgactg aatcaggcgc tctttcccga taaattcttc aacaaactca tttgccgggt 3121441 ttcgaagaat ctcatcaggt gtgccgactt gaacgatttc tcccgctttt aatatcacaa 3121501 tcctgtcagc aagcttaatc gcttcatcca tatcgtgggt tacaaacaca atcgttttgt 3121561 ttaaggttct ctgcagtttt ttgaattctt cctgaaggga atcacgcgta atcggatcaa 3121621 gcgctccgaa cggttcatcc attaaaatga gagggggttc cgctgccagg gcgcgcagca 3121681 cgccgattct ctgctgctgt ccgccgctga gctcatgcgg ataacggtct aaatactctg 3121741 ggcccatatc cacaagcttt aacagctcgc gcgcccgttc tttccgtttt tcctcaggcc 3121801 atttcagcag ctttggtacg agtgagatgt tctgctggat ggtcatatgg gggaacaaac 3121861 caatctgctg tatcacatag ccgatttttc tcctcagctc aaccgggtcc tgttccataa 3121921 tattttctcc gtcgataaag atccttccag acgatggttc tatcagtctg ttgatcatct 3121981 tcatcgtcgt cgtttttccg cagccgctcg ggccgataaa acagataaat tcaccttttg 3122041 caatatctaa atcaatgctg ttcacagctt ttttgccgcc tttatatact tttgacactt 3122101 gttccaattt cagcaatccg tgcacctccg caggtttcct ttaaattttc tgaaaagtat 3122161 aatccttatt atagtttgaa ctttgtaaaa taaaaagttt acaatgtgtt gaaattatat 3122221 gttatttata gattatttat tgttatgacc gagacggaaa gggtgttctt acaattactc 3122281 cggatacctc ccacttcctc tgcattcagc tattttcaac accaggaaga aatatgatat 3122341 attgacacca tcaattgcca tttgaaggga tgatcagctg tgaaaaaaac cgctctcgac 3122401 atcattgaac atgctgaaga gcatctcatt gagaagattg ccgaaaatat gcatacgttt 3122461 ggaatgcctt caactgtcgg acgtgtgctc ggaattattt atatgaatcg aaaaccaatg 3122521 accttaagcg agctctctga ggcaacgggc atgagcaaaa cacggatgag ccaggttgtc 3122581 cgggaaatga tcgatgccaa tatcgccgaa aaggtgtttg aaaaaggcgt acgaaaagac 3122641 ctttatgacg tcgagcagga ttattatcaa accttcattt ctttatttgc ggcgaattgg 3122701 acaaaggtcg tgagcaaaaa caaagtgctg tataaaaaat taaaccggga gctgagtgat 3122761 cttttacaaa gggacgggct taccccggaa gcggaagaga aagtcaatca gctgctgaat 3122821 gaattaaaag aatggcttca ttactatgat tggctgagca ggttgattga attttttgag 3122881 agtgaggaag tctttcggta tgtgccgaaa acaaaagaat gcagctctct aaaataagag 3122941 agctgctttt tgcatcatga agttaagacc ggaaacatgc ctttcagccc ggcaccaatc 3123001 atcccgaccg caaccacggc taagattaat cccatcagtc tggtaatcac attcatctcg 3123061 gtttttccga gtttgctgct gataaaagca gaatagtgga aaaagagaaa ggtcagggca 3123121 ataacggcgg ctatgccgat catgacagcc gcataatgac caatgccgct atgtccggcg 3123181 gaaaggctca tcactgttgc aatcgttccg ggcccagcaa tgatcggaat ggataaaggt 3123241 gtgactgata tatccgcttt ttccttgctt tccttatgtt catcatggtg aagagattgc 3123301 acgtgcgatt ctttcgcatt caatagatta taggcaatgc cgaaaatgaa tatgccgccc 3123361 gccactcgga gcgcgtgaat gttgatatca aacagtttaa agataagatg accgaaaacc 3123421 aaaaaagctg cgagaataaa aaaggataaa atagctgcct tccgggcaat cgcttttctt 3123481 tccgctgcag tatagccttc tgtcagcgtc agaaatatcg gtacgtttcc gatcggattc 3123541 gatactgcga ataaagaaat gaagacgtga acgataaatg agaacatcat atacctcctt 3123601 gttgatagtc tctgcacagg aaatagaatg attctccacc cttttacccg gaggcgattt 3123661 cccggtaaac ctttatagcc tgtcagaaac gcgccatgct acaatgaagt gacaaattga 3123721 ataggaagga cgtatacaga tgttcaaaaa aattgcggca gatgccttgg gcttatctga 3123781 tatcggaaaa attatcgaac ctcaggacta tgacaaaaca gacgcagatg actatgtcat 3123841 gcatgaagat aatgagaaaa tttatttctt gattaaaaca aaagcagacg agtattgctt 3123901 tacgaacctg gccctgatcc atgtggacgg cgaacgcgcc acttcctcaa aacgaacgtt 3123961 gaaacgctat ccttattcgc aatataaaat ctctgacgtt tttcttgaaa ctgccggaaa 3124021 agtggatttg gatgttgaaa ttaagttcaa gctgggcggt gaacaattcg acattgatgt 3124081 ccacaaagac cagattgaaa agttaaaaga cctttataaa gcactgcttc gcatcgctga 3124141 aacaacctat gaaaatgaca ttttaatcaa tcaagcggag caaagcttag ataaagcagt 3124201 gacgattctt caccataccc gccctgagca cgtcaatatt gaaacgcaat acaaagagct 3124261 gaccgaattc ggattcactt ggctgacatc cgttcgctcg cagtatcata ttaaggattt 3124321 tggggatgta tttgagaaat atattaataa ctagataaaa aaagacacag ctgctatcgt 3124381 gctcgtgtct ttttttgtat gaatattgat tactttacaa cttttttctt ttataataaa 3124441 actattagtc tattttccct atattacaga taaaggagtt attttatgta ttgtcctcaa 3124501 tgcggccatc aaacagatgg cggaaatttt tgtgagaaat gcggatcacc gctccccggt 3124561 caatcaggcc accagcatgc agctcaaact ggagccgctg caaagcaagc agcaaaacag 3124621 ttcggttcat ttgtcttatc cgtcctgaaa cgcccttatc aggaatgtaa agcaacaggc 3124681 ggagaacagc tgatcagcgc aatcattacg atggttcttt tcagtttgct gacccctttg 3124741 atgttttata ttcttttttc agacggtccc ggaagcgtaa gctttacagc aatcttctta 3124801 gagccaacca tttattttat tttatttcta tttggcctgc atgcatgcat ctttttcgcc 3124861 ctgaaaatcg cgggaaacca agtgtctttc aaggattcat tctcaagatt cggagcattt 3124921 cttattcctt ttacggctat tttgattctt gcccttttct tctttttatt acatacagac 3124981 atttgcttta ccatattagc cgttggttta atcggtgcat tcttcgccat tcctcctgcg 3125041 atgctgagca gttaccagca ttcatataaa gggaaggttg atttcattta ctcaacgatt 3125101 gtgatttatc tgatcatctg cgttacattt cagcttatta tcgaacacta tgtcaaagaa 3125161 attttccgtt atatgctctt ttaaaaacaa ccccatcacc tgctggtgat ggggttgttt 3125221 tattgaatag acgttaagta aattcttccg ttcttcacta cgccggtgta ggtccagtta 3125281 tatgttctga gctttggact gccgcctgat tttgtgatat agaattcttc atacgtctta 3125341 atcgtgatag ccgacccatt ttggctccag cttttcactt catagttatt aaagtcttct 3125401 gttgtcccct ctttatttaa tttcgacacg agatgctgct ggtcggaata aagggaactg 3125461 cctttttcaa ggctgtcttc catcagtgag aaattatttt gattcacggc atctgcctga 3125521 ctttgcagat aactgcccat aaataatgtc acttgttcat ctgtaacatc gccgcttgca 3125581 gagctttcac tgcctttgtt tttcgagcca gcccaggcgg aagtgtatgt ctctggttta 3125641 tcatttttga ttttctttat atttgtgcct gcagattcga atgttgattc tgcatcttcg 3125701 aaaatccact ttttctgttt tttatcatat gaaagaagat attcataact cggactgtcg 3125761 tcagtcattt cagactttgt atagtcgtta tacgaagaag actggtgaag ttcttttcct 3125821 gttaccgata cctgccacgt tccgtcgttt ttctgagaga gggcaaatgt gtccaggtca 3125881 aaatcagttt ccaagtatct atcttttaag tatgaatccg cgcttttcat agaatcgacg 3125941 gtgtccttcg tctccgcctt ccaattggca cttgcctctg tcatctgggc tgtattccca 3126001 tcagatagag ctttggagta ttgttttgtt gttttgacaa ttgtgttcat aatctgttcc 3126061 tgtgtatctt gatcaggaat taacgttaac tccatttctt tatcatcgat cggaacgccg 3126121 gcagtttttg tttttcccca cggaaattct gcctcgactg aagctgtcat tgatccatct 3126181 gtcagcagcg gaccatatgt tacggatttg aacggatctt tatgaattga tttaccgtta 3126241 atcagcaaat ctcccttccc gctcttgatg tcattcgcta agctgaatgt cacatcgtct 3126301 gcttccaatg agagatcaac acgaaagctg ctatcgccaa tcgcctgaat gtcttccttt 3126361 ttcacaaggt caacgacatc gtttttcagt ttggctgaga ctgtatattc gccgggaatg 3126421 tacggaccaa gggtttgtgc ttgatctgct ttctttacag atccggcttc ctctttattg 3126481 acatatagat cggtattttt ataattgctg ctcacttcaa aataaacagg tgctaccttt 3126541 aagtcataat ggtcaaatac cagcaggctt ttcccgtctt tttccgcata tacgatatcc 3126601 ttctgggctg tttcatcacg cagcgatgca aaaagttcat cttttttgtc tggatgatcc 3126661 ttcaaatatg taagaaacgg ttttacatta tttttagtga gtttaagatt gtcatttacc 3126721 ggtgtaagca gagtcgcgat ttggtcctga tccccatcat ttacggcctg ttcaaacttg 3126781 tctactaacc tatcctttga agtaaaatac gctccggttt tatatgcggc gaataatata 3126841 acgcacgccg cggcaatgct gctccataaa atgatggttt tcttagggat cggttttcgc 3126901 ggagcctgcc tcgtttctgc agtgctagct gtttcttgat ttgcctgttt gctgccccct 3126961 ccgatcgggg tgccgcattg tttacaaaac ttggctcctt cattattctg ggagccgcaa 3127021 ttcttacaaa ataacatgac tttcctccta ttctactaat ttgataacat ttactgcttt 3127081 tcatatttta taataaaaca gaatgaaatt gggaacgaat gaaaaaatta aatgtctatc 3127141 agactaaaaa ggtggaatga atatgcaaaa gctcaggatt gaattaggag aagaaacaaa 3127201 tgacgaatta tatgatctat tgctgctcgc cgatccatcg aaagacattg tagatgaata 3127261 tcttgagagg ggagaatgtt acacagcttg ggccggtgat gagcttgcag gggtttatgt 3127321 attgctaaaa acaaggccgc aaacagttga aattgtaaat attgcggtaa aagaatctct 3127381 tcagaagaaa ggctttggca aacagcttgt acttgacgcc atcgaaaaag cgaagaagct 3127441 gggggcggac acgattgaaa tcggaacggg gaattcgagc attcatcagc tttccctcta 3127501 tcaaaaatgc ggattccgca ttcaggcgat cgaccacgat ttctttctca gacattatga 3127561 tgaggacatt tttgaaaacg ggattcaatg ccgcgatatg gtaaggcttt atttggatct 3127621 ctgaaagcat aaaaaagccg ccgagagaaa atcccggcgg tctttttatt acttgtttaa 3127681 gttgtagaaa gagttgatac cgtggtattg agcagtttca gccaactgat cttcgatgcg 3127741 aagaagctgg ttgtatttcg caacacggtc cgtacgagac ggagcacctg ttttgatttg 3127801 tcctgcgttt gttgccacag cgatgtcagc gattgtgctg tcttcagttt caccagaacg 3127861 gtgagagata acagctgtgt agcctgcgcg tttcgccatt tcgatcgcat cgaatgtttc 3127921 agtcaatgta ccgatttggt ttactttgat caggatagag ttgcctacgc cgtttttaat 3127981 accttcagaa agttttttcg tgtttgtaac gaagaggtcg tcaccaacaa gctgaacttt 3128041 tttgccaaga cgctcagtaa gaagcttgtg gccttcccag tcgttttcgt caagtccgtc 3128101 ttcgatcgag atgattgggt atttagaaac aagctcttca taccagtcaa ccatttcagc 3128161 agatgttttc acaacgcctt cgccagacag atggtatttg ccgtcttctt tgttgtagaa 3128221 ctcagaagat gcagcatcca tagcaagttt aacttcttcg ccaggtttga agccggcttt 3128281 ttcgattgct tcaacgattg tttgaagcgc ttcttcgtta gaaccaaggt ttggagcgaa 3128341 tccgccttcg tcacctacag cagtgtttaa gccttttgcg cttaatactg atttcaggct 3128401 gtggaagatt tgagcgccca tgcgaagtgc ttcacggaag ttaggagcac ctacaggcat 3128461 gatcatgaat tcttgaatat ccacgttgtt atcagcatgc tctccgccgt ttacgatgtt 3128521 catcatcggt acaggaagcg tttttgagtt gaatcctcca aggtattggt aaagaggaat 3128581 ctgtaagaaa tcagcagcag cacgcgcaca agccatagat acgccaagga ttgcgttcgc 3128641 accaagtttg cctttgtttt cagtaccgtc aagctcgatt aaaagctgat cgattgcgtt 3128701 ttgttcagtt acatcaaagc caagaagctc tggagcaatg atttcgttta cgttgttaac 3128761 agctgttaac acgccttttc caaggtaacg gtctttgtcg ccgtcacgaa gctcaaccgc 3128821 ttcgtattca cctgtagaag ctccgcttgg cactaatgcg cggccgaaag ctcctgtttc 3128881 tgtatatact tcaacttcaa ctgttgggtt gccgcgggag tctaatactt cgcgtgcata 3128941 aacatcaaca atgtatggca tgagttttgt ctctcctttt gattttcaaa ttatttttga 3129001 attaaagatg ttcctgtcat ttctttcggt ttttcaacac caagaaggtc taataacgtt 3129061 ggtgcaaggt cgcctaggat tccgccttca cgcagcgtaa tgccttcttt cgttacaatc 3129121 acagggactg ggtttgttgt atgcgcagtg tgcggttcgc ctgattctgt aatcagaatg 3129181 tcagcattac cgtgatcagc ggtaatgata gcgtgtccgc ctttagcaag gatcgcgtca 3129241 acgacttcgc ccaagcattc gtccactgct tcaattgctt taattgttgg ttcaaccatt 3129301 ccggagtggc cgaccatatc agggtttgcg aagttaagaa tgatcgcgtc atgcttgtca 3129361 gcttcaattt ctttgacaag cgcgtctttc acttcatacg cactcatctc aggcttcaag 3129421 tcatacgttg caactttagg cgagttgatg agaatacgct cttcacccgg gaattcagct 3129481 tcacggccgc cgctcataaa gaacgtgacg tgcggatact tttcagtttc tgcaattcga 3129541 agctgtttta acccgtgctg agataatact tctccgactg tgttatcaag atttatcggt 3129601 ttaaacgcta catagccgtc aactgtttca ctgaagtgag tcaggcagac gaaatacagg 3129661 ttctttggat aattctcgcc gcggtcgaag tcacggaagt ctttgtttgt gaacgtgttg 3129721 gaaatctgga tggcgcggtc cggtctgaaa ttatagaaaa tcacagaatc gccgtcttgg 3129781 attttcgcaa caggctcacc gttttctttt gtgatgacag atggaatcac gaattcatcg 3129841 tagataccat ttgcatatga atcatcaaca acatccaggg cgctgcggta agatgggcct 3129901 tcgccgtacg ccattgcgcg gtacgctttt tctacacggt cccagcgttt gtcgcggtcc 3129961 atagagtagt aacgtccgga aatgctggcg atttcaccta caccgatttc cttgatttga 3130021 tcgttcaact ggttgatgta cgttttcgct gtctgcggac ctacatcacg gccgtcaagg 3130081 aagccatgga tataaacctt tgtcagccct tcttttttcg caagctttaa cagtgcgaat 3130141 aaatgattga tatggctgtg cacgcctccg tcagataaaa gaccgaacag gtgcaaggct 3130201 ttgttgtttt ctttcgcgtt gctgatcgcg tcaaggaatg tttgattgcg ttcgaactct 3130261 ccttcacgaa tggcaacatt tacgcgtgtt aagctttggt acacaatacg tcccgcaccg 3130321 atatttaagt gacctacttc ggagttcccc atttgccctt caggaagacc tacagcctcg 3130381 cctgaagcag tcaaagtttg atgaggatac tggttccaat agcggtcaaa attcggtttt 3130441 ttcgctaaag cgactgcgtt ccctactgtt tcgttacgta atccgaaccc atcaagaatg 3130501 atgagtgcag ctggtttttt actcatattg accttcctcc aataattgaa cgaatgactg 3130561 tggctcaagg ctcgcgccgc cgaccaaagc accgtcaata tcggactctg ccatatattc 3130621 tttaatgttt gcaggcttta cgcttccgcc atattggatg cgaagcttgt ctgcagcttc 3130681 ttggctgaag ctttcagcga cggttttacg gatatgcgca cacacgtcat tcgcatcttt 3130741 cgctgtagaa gatttgcctg ttccgattgc ccagattggc tcatacgcaa taacagaagc 3130801 agcaacttgt tcttcagaaa gaccagcaag gccttttttc acttggtcag caacaagatc 3130861 atttgttttg ccggcttcac gctcttcaag cgtttcacct acacagatga tcggcacaat 3130921 gccgtgtttg aaagctgcgt gtgctttttt gttaactgtt tcatcagttt cagcgaacat 3130981 ttcacggcgc tcagagtggc cgatgacgca gtagtcaacg ccaaggtctt tcagagcaac 3131041 cgggctgatt tcgcctgtga acgcgccgct ttcttcgaag tgcatgtttt gagcgccgac 3131101 ttttaggtca gtgcctttca cagcagaagc aagcttttct aagaaaagcg ctggcgcgca 3131161 aacaacagct tcagctttgt ctgctgctgg aatggaagat ttcacttctt caacgaagct 3131221 gacagcttcg ccgagtgttt tgttcatttt ccagttaccg gcgataattg gttttctcat 3131281 ctgttccact tccttatagc agttttgaga ttatttatcg ttcagtgcag ctacccctgg 3131341 aagctctttg ccttccataa actcaaggga tgcgccgccg cctgttgaga tgtggctcat 3131401 tttgtcagca aggccgaatt tttcaaccgc tgccgcagag tctcctccgc cgatgacaga 3131461 gtatgtatct ttcgcctctg ccaatgcttc cgcaaccgct tttgttcctt gagcgaacaa 3131521 gtcgatttcg aatacgccca ttggtccgtt ccacacgaca agtttgctgt ttttgatgac 3131581 gtcagcatac gtttcgcgtg ttttcgtacc aatgtcgatt gcttctaaat cactagggat 3131641 ttcagagatc ggcacaattt tcacgtttgc atcgttagag aaatcatctg caacgagtac 3131701 atcttcaggc atgtagaagt taacgccttt ttctttagcg cggtccataa atgatttcgc 3131761 aagctcgatt ttatcctctt caagaagaga tttcccgact tcatagccaa gcgcttttac 3131821 gaaagtataa gcaagacctc cgccgatgat caggttgtct actttatcaa gaagactttc 3131881 gattacaccg attttgtctt ttactttcgc tccgccgatg atcgctgtga acgggcggtc 3131941 aggattggaa accgcttttc caagtacatc aagctctttt tccattaaga aacctgcaac 3132001 tgctggcaga tgctcggcaa ttccagctgt agatgcgtga gcacggtggg cagcaccgaa 3132061 tgcgtcattt acatatacat ctgcaagctc agcaaatgct tttgcaagct caggatcatt 3132121 tttctcttca ccaggataga aacgtacgtt ttccaataca agaacgtctc cgtccttcat 3132181 ctcagaaatt tgtgctttta cagcatcgcc gtatgcttca tccgcttttt tcacttcttt 3132241 gccaagcagt tcgccgagac gtgcagcgac aggagttaaa cgaagctcct caaccacttc 3132301 gcctttcggg cggcctaagt ggctcgcaag aaggactttt gcgccttggt ctgcaaggtg 3132361 tttgattgtt ggaagcgcag cacggatacg tgtatcgtct gttacttccc cgtctttcat 3132421 tggaacgtta aagtcaacgc ggcagaatac aactttgcct tttacgtcga tgtctttgag 3132481 agttttttta ttcatgccta ggagatcctc cttcaaaatg gtttgcatac agcacgaaaa 3132541 acgtgaaacc gtctgttcaa gcgataactc cgctagggca gatcgcagtc tttttcggca 3132601 cagggcagtt cgtctaaaag ccagggcagc ggccttaggc gaaagcgccg gcaaagctgc 3132661 ttaaaacgcg gtcgtttctc tatcacagag cgttttctga aagccggtct tcatggaaaa 3132721 agggaaaggg agtccgtccc cttcccttgt ccgctttcat tatagcgctt ctattcgaaa 3132781 gaaccaagtc aggtcctttt tcagctataa attaaagacc tttttttgcg atgtaagctg 3132841 caaggtcaac aacgcggtta gagtagccgc tttcgttatc gtaccaagag attactttta 3132901 ccatgctgcc ttccataacc attgtagaaa gagcatcgat tgtagaagag tttttgtttc 3132961 cgttgtagtc gccagaaact aatggctctt cgctgtagcc aaggattcct ttaaggtcgc 3133021 cttcagccgc ttctttaaga gctgcgttta cttcttcagc tgttacttct tggttcagtt 3133081 cagcaaccaa gtcaactaga gaaacgtttg gagttggaac acgcattgct ccaccgttca 3133141 gtttgccttt tagttcagga agaactagag aaactgcttt agcagcacca gttgatgttg 3133201 ggatgatgtt ttcagctgct gcacgcgcac gacggtagtc tttgtgcgga agatcaagga 3133261 tttgctgatc gtttgtgtaa gagtgaacag ttgtcatcat accgcgtttg atgccgaatt 3133321 tatcgttaag tacttttgca aacggcgcaa ggcagtttgt tgtgcaagat gcgttagaga 3133381 taacatcgtg gttagccgca tcgtatttat cttcgttaac acccataacg attgtgatat 3133441 cttcttcgtt agcaggagca gagatgatta cttttttcgc gccagcttct aagtgtttcg 3133501 cagcgtctgc gcgttttgtg aagaaaccag tagattcaac tacgatttca acgccttgtt 3133561 tgccccagct aagtttagca ggatcgcgtt ctgcagaaac ttcaattgtt ttgccgttaa 3133621 caacaaggtt gttaccgtca actgaaactt cagcgtctaa ttttccgtgt acagaatcat 3133681 attgtaaaag gtgagccagc atgttagcat ctgttaaatc gttaaccgct actacctcaa 3133741 cttcaggatt gtttaatgct gcgcggaata cgttacgtcc aatacgacca aaaccgttaa 3133801 taccgacttt tactgccatg attgtttcct cctttaaata agtgagagat atttatattg 3133861 agggattatt catcccttaa taacttcttt gcggctcctt cgtctgtgac gagaaccgtg 3133921 ttgcgtggct ttttaaagta agcctcgatc gcttcggctt ttgatgatcc gcccgctacc 3133981 gcaataatat cggggatggc gtctatgtca tccagctgca ttccgacaga atgcactttg 3134041 tgaaccactt cgccgtccgc gttaaaatag tagccgaacg cttccgtcac cgcgtcgtta 3134101 tcatctattt tctttaaatc ttctaaaggc gtgtttctgc gctgagccat agttttagct 3134161 tcgccgattc cgtgaaccag catactcgct gatttaatgg tgttcagcac ctctttgaca 3134221 gaaggctctt caataataga tgaataggcg ccttgtgaca gctgtcccgg aacaaacaaa 3134281 agccggtaag tgcctgaagc cttctccgcc atatgcgcgc atatggtgtt cgcctggttt 3134341 ttcacgtctt cgcctaaacc gcctcttgca ggcacaaaca aaagctcgcg gtttttagaa 3134401 tccggcgtca tcatttcggc gacagcttca attgtcgtac cgccagttac agcgacgata 3134461 tttttgcctg aaaatctttt tttcatacat gcgacagccg ctcttcccat ttcttttttg 3134521 acccatgggg attgatcgct gtctccggat acgataatgg catcctttag atttaaacgt 3134581 tcttttaatg tcttttccaa aagagtcaaa cctaaaacat ctttcatcgt atcttccaaa 3134641 acagaaagca gttcatagcc ctcttctgtc aatgtcatgc cgtttgtctt aatatcgacc 3134701 aggttctgtt cctttaaaaa ctgaacctcg cccctcagca cacgctcgct gattccgaga 3134761 ctggcagaca ggcttcttcg cccgatgggt tctgtcagcc tgatatactg caagatttca 3134821 aacctctttt gcataacgag cagaagatca ggcaataatt ttttttgagc ttgtattaac 3134881 tggttcatga ctcaaacgtt ccttcctttt ttgctggaca ttatatgtcc cgctatgaca 3134941 aaaaacgtcc cgtcatagcc aaaaaaaatc atttctgctt tctttaatta ttttaacagg 3135001 gtggaattgt ttattcaact gttaagagcc aattcatcga caatattcgc agagttttca 3135061 tgccgcgtcg ttttatccag caatatttta tcctatatat ctttatctta tacagaaagc 3135121 gccaaatggt gcatcccaat ataaacagcc cttcccgtag aaagggctgt ttcattaaag 3135181 cgttttcatt ttatccaaag cttttcaatt tcctcgagcg atttgttctt cgtttctgga 3135241 cagatcgtaa cgacaaacag gaaacaaagg atgttaatca ccgcaaagat ccaaaatgta 3135301 taggcgagcc cgaaagaatc gatcatcatt ggcacaaact gtccgatcgc ccagtttgct 3135361 ccccataaaa agatggtcgc aatgcccgcg gcccgcgcac gcagatggtt cgggaagatt 3135421 tcagaaatca taatccatgt gatcggtccg accgagacac agaaagcagc gacaaaacct 3135481 aatataagga cgatcatcat gatcccgctt gttaactcaa aataaaacga cgtcccgatt 3135541 aaaatcataa aaatagccat aaaagcagaa ccgatggaca tcagtttttt tcgtccgact 3135601 ttatcaatca gcaacaccgc aataacggta aaaataactt ctacaacccc gacgatacaa 3135661 gtcgtcacaa atccggcgtt ttgcccgaat cccatcattt taaagatttc cggcccgtag 3135721 taagtaatcg cgttcatgcc gatgacttgg ttaaacagcg ccagcaggat tccaatgaca 3135781 agcgcctttc tgagacccgg cttaaacagc tgggagagcg accccatttg ttctattttt 3135841 aaagagttct caatgttctt taattcttct tttgcaacag tttctccatt aatacgtgtc 3135901 aggatcttta aagcttcatt tgttttgccc gctttcgcca gccatctcgg actttccggg 3135961 acgacgagca ggacaaggaa aaaaatgacg gatggcacca ttccataagc aagcatccat 3136021 ctccagccgg tgtgcacgcc ccattcgtat gttccggacc gctgcacagc tagattaata 3136081 aagtatgttg cggaaatacc cagtatcgta aagagctgat ataacgaaga taaacttccg 3136141 cgtatagcgg gcggtgccgc ttctgtaata tacgtaacag agagcgatga gcccatcccg 3136201 attcccagcc ccccgataat ccttgcaatg attaaggtgg acacgtcttg agaaagcgct 3136261 gaaacgattg ctgatatcgc aaataacaaa gcggctgtca ttaaaatttt tctccggccg 3136321 aatctgtcac ttaaaaatcc ggatatcccg acgcccacaa ctcctccaat cataatgctt 3136381 gaaatgacaa gtccctccat aaacggactc aggctgtata aatctttcag aaaaccgatg 3136441 gcgccagaaa tcactgccgt gtcatagcca tacaataagc cgccaagccc cgccgcacat 3136501 gagatcaaaa tgacaaatcc cattgaatgg cttcttgtta caggaacatt tggttctaat 3136561 tgagttggag tattcttcat ttccctgccc tcccgaatgt tgagtaaagc gttttcattt 3136621 aaaccttcaa ttgtacgtac ttatattaaa atttaacgaa aattacattt aattagtacg 3136681 tacaaatata gaataatctt gtttgcattt tctgtcaatg ttttcttaca aagaacgctg 3136741 tgatatactg aaatttgtcc gtatacattt tggaggaatg gatatgttac caaaatacgc 3136801 gcaagtaaaa gaagaaatca gttcttggat taatcaaggc aaaatactgc ccgatcaaaa 3136861 aatccctacc gaaaacgaat taatgcagca attcggcgtc agccggcata ccatccgcaa 3136921 agcgatcgga gacctcgtat cacaaggtct gctgtacagc gtgcaaggcg gaggcacctt 3136981 tgtcgcttca cgctctgcta agtcagcgct gcattccaat aaaacgatcg gtgttttgac 3137041 aacttacata tcagactata ttttcccgag catcatcaga ggaatcgagt cctatttaag 3137101 cgagcagggg tattctatgc ttttgacaag cacaaacaac aacccggaca atgaaagaag 3137161 aggcttagaa aacctgctgt cccagcatat tgacggactc atcgtagaac cgacaaaaag 3137221 cgcccttcaa accccaaaca tcggctatta tctgaacttg gagaaaaacg gcattccttt 3137281 tgcgatgatt aacgcgtcat atgccgagct tgccgcgcca agttttacct tggatgatgt 3137341 gaaaggcggg atgatggcgg cggagcattt gctttctctc ggccacacgc atatgatggg 3137401 tatttttaaa gctgatgaca cacaaggcgt gaaacggatg aacggattta tacaggcgca 3137461 ccgggagcgt gagttgtttc cttctccgga tatgatcgtg acatttacaa cggaagaaaa 3137521 agaatcaaaa cttctggaga aagtaaaagc cacactggag aaaaacagca agcacatgcc 3137581 gacagccatt ctttgttata acgatgaaat tgcgctgaag gtgattgata tgctgaggga 3137641 gatggatctt aaagtgccgg aggatatgtc tattgtcggg tacgatgatt cacatttcgc 3137701 ccaaatctca gaagtgaaac taacctctgt caaacatccg aaatcagtgc ttggaaaagc 3137761 agccgccaaa tatgtcattg actgcttaga gcataaaaag ccgaagcaag aggatgtcat 3137821 atttgagcct gagttgatca ttcgccagtc cgcacgaaaa ctgaatgaat aaaaaaagca 3137881 atgtatgggt ctccccgcta cattgctttt tttatagctg ttatctgttt ttccaaacgt 3137941 cagcgatgat ttcaaacgaa cgcattctgt ctgcgtgttc aaaggtttct gagttaacca 3138001 taatttcgtc agcctgtgtc gttttgacga aatcttcaag cttcgccttc acttcttccg 3138061 gacctccgac aatcgtggag ctcagctgct cattgaccat cgctttttca tacgggctcc 3138121 agatttggtc catatcctca acaggcggtt taagctggtt aggcgtaccg cggacaagat 3138181 caagaaacct ttgataatgg gaagtcgcaa ggtgctgcgc tttctcgttt gtatctgccg 3138241 cgataatggt gacaccgacc atcgcatacg gttcgtcgag cacgtctgac ggcgtgaagg 3138301 aattgcggta cagctccaaa gcgggaaccg tattcgccgg tgagaaatgg gccgcgaacg 3138361 caaacggaag accaagttcg ccagccagac gggcgctgaa gccgcttgag cccagcagcc 3138421 aaatcggcac atctatgccc tctccgggaa tggcgcgaac ttgattgcgc acatttcctg 3138481 acggtttaaa ataattgcgc agttcctcta attgttctgg aaaatcctcc ccgctgttga 3138541 tgtttctgcg gagcgctctg gctgtcaatt ggtctgttcc cggcgcacgt ccaagcccca 3138601 gatcaatccg cccgggatac agtgtttcca gtgtgccgaa ttgttcagca atgactaatg 3138661 aagagtggtt ggggagcata atgccgccgg aaccgacgcg gattttcttc gtgcctccgg 3138721 caatatggcc aatcaaaact gcggtggcag agcttgcaac accttctata ttatgatgtt 3138781 cagcaagcca gtaacggtga tagccccatt cctctgcccg gcgcgccaag tccatgctgt 3138841 ttcggaatga ttctgcaatc gttcctccct gaacaaccgg agataaattc aagacagaaa 3138901 gcaaggtatc tttgcgttgg ttgttagaca tattgttctc ctttgcaaat gtgttatcag 3138961 taaacagccc aaagctgtca ggtcatgatt gaaagaactt ctatcacacc ataacacaac 3139021 tgcattcagg aataaaagaa tttgattcga tgaaattcga acaatataaa acgaacggtt 3139081 tggaacatta ttctgctcca aacaactcct tagccatctc aataaagagc ttagccgcca 3139141 gagaagcctc ctttagcgac ggaacagcaa gctgcacatc acggtatacc tgcgggtcca 3139201 attccctggt caccacatgc tctggcagcg gcatccccga catggacatt tctgataaaa 3139261 tggccaggcc caggccttct ctgatcatac tgatcgaggt gttgatgtta tagaccgtga 3139321 aagctgggtg cagcgtagca cccgcctgcc tgaacatatc gataaatggt gattcatagc 3139381 cgccgtcaca gacgatcatc ggttcatggt caagatcttt cagcgtaatg gctgaatgac 3139441 tggcaagcgg gtgatcgtcc ctgagcacga cagccatttt gtcttttttc aaatgaatgt 3139501 actccatctc ctctgttgga tacagaagaa tcccaacatc tatcatccgc gtatgaagcc 3139561 actccttgac ttcatttaca gttccctcgt gcagcacgag ctcaagtttc ggatattttt 3139621 gtttaaattc actgatcagc ttcggcataa aataagccga ggcagttgag aatgtgccga 3139681 tatggatcgt tcccagttca agcccttttt ccgctgctgc tacctgctca actttttcaa 3139741 tgccttttaa gacttctctg atgtgtacta agatctgttt tcccgtatcc gtcagcatca 3139801 ggccattgcg gcggtcacga atgatcagct ttacatcaag ctcagcttcg atcgcagaaa 3139861 tcgcatggct gacagccggc tgtgtcatgt tcagcgcctg acccgctttt gtaaagcttc 3139921 ccgtttcagc tattttcaca aaaaccttta attgagtaat ggtcataaca atttacttat 3139981 gctccttata aaaaagattc attttattta tcttatgttc taccgtatca tatgatggaa 3140041 aagttctaca aggagtgaat gaacaatgaa gcagctccca aaaacgcgga cagctctcct 3140101 gctcgcattt ctcgtcatca tgtggggcgt caattggccg ctgtccaaag ccgcgctcgc 3140161 ctattctccg ccattattgt tcgcgggcat ccgaacgctg atcggcgggc ttttattagt 3140221 catagtcgca ctgccgcgta ttcataaatt acgcttaaaa gaaacgtggc cgatttatct 3140281 tgtttctgct cttttaaata ttacattatt ctacggcctg caaacgatcg ggctgaatta 3140341 tcttccggcc ggcctgtttt ctgcaatcgt cttcttccag cctgttctga tgggtgtatt 3140401 ttcttggctg tggctcggcg aatccatgtt tgtaatgaaa gtgattggcc tcatcctcgg 3140461 ttttgcggga gtagccgtca ttagtgctgc gggctttggc gggcatattt ctgtcattgg 3140521 ggttctgctg gctctcggct ccgcagtcag ctgggcgctc gggacagtat atatgaaaaa 3140581 aacaggcagc cgcgtcgatt ccatctggat ggtcgctctg cagctgacga tcggaagcgt 3140641 gtttctgctt atctccggct tttggacaga aagcttttcg gcgatccaat ggacagctcc 3140701 gtttattacg agcctgctgt tcatctccgt attcgttatc gcactcggct ggcttgtctt 3140761 ttttacgctt gtcggttcag gagaagcaag caaggtcgca tcttatactt ttttgattcc 3140821 gctcatatca atcgtggcca gctccatttt cctgcatgaa ccgctcaccc ttagcctctt 3140881 ggcagggctg ctgctgattg tcacgagcat ctgtctcgtg aatacaaaat caaaagcgca 3140941 gaaagctgcg gcgattggta taaacgagaa agctgcacaa taataaaaac cctcttgccg 3141001 gatgcggcaa gagggtttct tatttactga tgcttgcgtc ctttgaccaa atatgcaact 3141061 gtaatcaaaa ggtagatcgc cgcagtaatg ccggtaatga caattgatgt tgtcatgatg 3141121 accccgatca gaatggcgag taatgccaca atcgcaaacc atgtcgtgta cgggaaccat 3141181 tttacataat aggccggtgt ttccgtttgc tgttttctcg attttaaatg agcgaatccg 3141241 atgatcagcc aaatgaataa aacggtatat cccaatgatc ccattaaata attaaatgtt 3141301 tggcttcctg cgaacagaga aatcaatacg ccaatataga gagaagaagt gcacatcaga 3141361 atcgcaaaca tcggtacgtt tttcgatgaa agcttcgaga agacctttgg aagccttccg 3141421 tcacttgcct gtgtatacaa aatgcgtgat gatccgtata aacctgaatt catagaagaa 3141481 atgatcgcca gcaggatgac tgcattcatg atatgatccg cgcccggaat gcctaccatt 3141541 ttaaagacca tcacgaaagg actttccgga acggaattga cttggttcca tggaatcagg 3141601 ctgacgatga tgaaaaacgg cagcaggtaa aacgcgacaa tccgtgtcag tgtgctgcgg 3141661 acagctttcg ggacaacctt ttccggattt tttgtctctg caagcgttac accgataatt 3141721 tctgtaccgc cgtaagagta gatgacgaca agcatcgccg tgatcagccc tgtgccgccg 3141781 tgcgggaaaa atccgccgtg gtctgtcagg ttggaaaatc cggatgctgt atgatcaccg 3141841 aatgatacaa ataagagcag caatcccaga ataataaaga taataataac ggtaatcttg 3141901 atcattgcca gccaatattc agtttcggcg aagattttaa cagaaagcaa gtttacaatc 3141961 gtgacgataa gagaaattcc taatgccaac acccagatcg ggcagcccgg cagccaatat 3142021 tgaatgaaaa tcgcagctac aacagcttca gccgcaatgt taagcaccca cattttccag 3142081 tagatccagt ccaaaaagta agcagcgtaa tttcccaata cctgctggac aagatcacgg 3142141 aaggttctgg cgttacggtt tcgaacagcc atttccgcca gcccctgcat aataaacagc 3142201 aaaataatcc cgccgagcag gtatgcgata atgacagatg gccctgccac atcgatcgct 3142261 gagctgctcc ccttaaataa acctgcgccg attgctccgc ccagcgccat catcataata 3142321 tggcgggacg tcatcgtgcg ttttaacgtt tgattgtcgt ttttcatcct cttctacctc 3142381 tccttctcgt tttcaaaaac aaaaaagccc gccgtctcct acctaatcta atagataaag 3142441 agacgacgag ccttcggctg accgcggtac cactcttgtt gattcttcat gaagaatcct 3142501 gcttttgacc tgtaacgaag gttagccgtt aaaacatagg gaatattcaa tctattccgt 3142561 tccgtcttac cactcccggg cgagttcaaa gaagaatcag gctgcgtcgc accaccccgc 3142621 agctctctgt tctgatcact ttcttttact gctcccaatc tatgtgtttt agttttctga 3142681 aaaactcaaa ttttatgatc tgaatatatt aacataatat acgtgcttct cttttaactg 3142741 tcaataactt cagagaaaaa agaaactgtt attttgtccc ttttcgaatg gctttccaaa 3142801 aggattctga ctcgtttcct aatgcgtaaa ctgaaacacc tgctatttta tattgctttg 3142861 ccagatggct tttcgtttga acggtttttt cgttttcata ccacacgaca tgtttatgct 3142921 tctttttgtc aacataagaa aacgtcatcg agcctgattt tttgttgaat gccggctttg 3142981 ctttttgttt tttgatgagg gatttgagct cattccattc ccttattgtg ctggtacttc 3143041 cgtcttttac atcccagtca tagccgtacg cagggattcc catgatgact ttattggctt 3143101 tgatcttttt gactgaaaac tgcagagagc ttttgatcca gtttgtgctt gccactgacc 3143161 ccggctcacc ccaaatgccg tgttcatcgt aggtcatgac ttgtacgaag tcggcatatt 3143221 tgccgatttt cgcataatca tacggccagc tccagtcatc atttttatca tcggcgcttt 3143281 tggccggaac ggataccatt gttttaatat gtttcttatt caaagcctgt gagacatatt 3143341 gaatgaagtt cgagtatgca gcgcggtctt ctggatttac tgcttcaaaa tcgatattga 3143401 ttccgtaata tgagtgcttt ttggccagtg taattaactg atctgtgaat cgttttttcg 3143461 ctgttttatt gctcatgacc cgactcgcta aatctccgtc aaaatcataa atggcatcat 3143521 tatagtttga aatgacagcc catgtcttga tttttttctt tttcgcatat gtcagctgct 3143581 tagttggggc atcgccaatg atttgtccgt ttttttcaaa cgcaaatgta tcggttgcga 3143641 tggcattcat gtatgtatga tatttcgtaa gagaattgta tgaagccgta tccccagtcg 3143701 tgtagcctac tgtcataccg gctgccttcg cttctccttt tgtatacata aacagaacaa 3143761 tcgcaatcgc cagtgaaacc gctatgatca gccatttttt catcgcattt cctcctgtat 3143821 caagtcatac tcttctcatc ggccaaaaaa ttggaagttg aagttttttc aagcaaaaag 3143881 cccggcatat gcctgccggg cttcctgagt tcagcggtca gagacgagaa tatatgctgc 3143941 ctttactggt ccatgcaccc ccacaactaa atccatttca atgtcggctg agttactcgg 3144001 tccggtaatg tagttgatac atgaaggaac agtgacaccg ttcgcaatgt tttggcggat 3144061 gatatcactg gcttgtgtca ttctcggtac aatgcttgat ttcggcacga tcgcaatata 3144121 agtcgttggc aaaaggctga cagagcggcc gatgtctttt gaggagaaga ggacaaccgt 3144181 ccccgactca gccaatgtaa tttcgctgaa tgtaatccct acattggctt gctccgcttt 3144241 tttaatattt tcctcgcctt tgtcagcatc ccactcccag accggcgttc cttcactcgg 3144301 ccagtccttg gtgagcaggc ttttcagtcc gtattcttca aagcgggggt ccttcggaat 3144361 gatgacaggg cctccagaaa agcggctgac ttgctcgcgc agggcatcgt aaaggccggt 3144421 tgaatccgtt tcaatcagct ctgtatggat tttgacacaa tggtttttga gcactgtgac 3144481 taagtcatcc gctgaataac cttcaagtgt tttatattgc ggctgatgcg cccattcagg 3144541 gactgccacg cctcctgttc ttcgttcacg gcccaggctg gatgcgattc ggtttaaaaa 3144601 gctctcttga ttctgaatgg ttcccttcgt catcactgct cctccttcgt gcgttcactt 3144661 gtttctctgt ccgcaaacca gtctctgaat ctcgatttat gcggtgccgg gaagtcgcga 3144721 atctgggtcc aatttttaag cgggccgggc cctttcgaaa ttttttcgtc ctctgtaaaa 3144781 ggcgtcatgg cggccggcgc ccattttgag cccattttgt aaagcgataa ggaggatgcg 3144841 ccaagtccga atgctttcat tgcaagcttt tcactgatcg gcgccctgcc ttctttttcg 3144901 acgatattct gacgatgctt gagtagcagc tcatgaagcg ggattttgac cgggcaggct 3144961 tctgaacaag cagcgcacag tgaagatgcg tacggcagct ccttataatc gtcataaccg 3145021 ccgagcaacg gtgataaaac agctccgatc ggccccgagt agattgagcc gtatgaatgt 3145081 ccgccgacat ggcggtacac aggacagaca ttgatacagg cggcacagcg gatacattgc 3145141 agcacagact ggaattccgt tccaaggata ttggatcgtc cattatcaac gatgacaaga 3145201 tggaattctt ccggaccgtc cacttcacct tccagcttcg gacccgtcaa agctgtaata 3145261 tagcttgtca gccgctgtcc gacagcactt ctagtcagca tgctgactag cacttcaaat 3145321 tcagaaaatg acgggacaat ccgctccatt cccatgacgg taatttgtgt tttcggcaag 3145381 gtgctcacaa gccgtccatt tccttcattg gtcacaaggc tgacggaacc cgtgtcagcg 3145441 atggcgaagt tacagccggt aatgccgata tccgcttcca gaaacttttt ccggagaatg 3145501 gcgcgcgcat gcatcaccag ctcttccggt ttttctgtat gttgatagtc cagtctttct 3145561 ttaaacacat cgcgtatctg ctctttattt ttatgaagag cgggcgctac gatatgtgac 3145621 ggcggatcgt gatcatcaat ctgcaaaata tactcgccga gatcggtttc tacgacttca 3145681 cagccttcct tctccagcac ctcattcaga ttgatttcct ctgtgaccat tgatttagat 3145741 ttcacaattt tcttcccgtt cttcttttga atgacatccc gaatatagga agacgcctct 3145801 tccgctgttt tcgcgaaata gacatgtccg cctcttttcg ccacattttc ggcaagctgt 3145861 ccgagataga aatcaaggtt ttcaaggaca tgctgcctga tttcctctga taatgagcgc 3145921 cactcctccc agtttcccag ttcttctgct gcctctaggc gccgcgtccg cagacgctcc 3145981 tgtgcacctg aaacagcgcc tctcataaat tcattatcaa tcccctgtga tacccgctct 3146041 ttaaaagcgt cagtaccgat tttcatcgcc atgatccttt ccccctctga atccagtttt 3146101 atctgctgtt gagcacttcg gcgatgtgca tcactttgac attcttatct tttcggccaa 3146161 gccgtccccc gatattcatc aaacagccgc agtcagcacc gatcagcacc tctgctcccg 3146221 tttcctccac acattcgact ttttcatcga ccatctgctc agaaatctgc gccatcttga 3146281 ctgagaacgt tcctccgaat ccgcagcagt tatgtttgcc cggaagctct gtaaactgca 3146341 ggcccttcac atggctcaac agcttcatcg gctccttccg aacacccagc agcctagtca 3146401 tatggcacga cgtatgtaag gtcgcttttg tatgaagggt cgcgccgaca tcctctaccc 3146461 caaggacgtt cacaataaaa tctgtcagtt catacgtttt atccgccagc tttttcgctt 3146521 tatcggccca tttcggatca tcctgaaaca ggtgcggata ctcccggaac atcgttgtgc 3146581 aggaacccga aggactgaca acatattcgg aatcctgaaa cgtttcgatc atccgtttca 3146641 ttgctttttt ggcgtcatgt acatagccgc tgttgtaagc cggctgtccg cagcaaatct 3146701 gcccttctgg aaaatcaacc tcgcacccaa gccgctccag cagctcaacc gttgcttttc 3146761 cgacatttgt ttgaaacata tcaacaagac aagtgacaaa aagtgagact ttcatgatga 3146821 acccctctct catccccaat atatgatcag gtcatctgat gacctgagtt aaaataacta 3146881 tatgaatatc gtacactatt ctgacaatgg aaggaaagag ttttctaggg atattttcat 3146941 ttgtggcata tcaaaaacac tcccgatctc ccaggagtgc agtatatggt tagatccagc 3147001 ccttttcctc agcgatgctg gcggcttctg tccgattttt cgcattaagc ttttggatga 3147061 tttctgagat atagtttcga actgtgcctt gagataaata gagctccagc gtaatgtctt 3147121 ttgttgtctt gcctaaagcc gcaagcctca gaatttcttg ctctctaacg gttagcggat 3147181 tttcgtctcg catcatatta aacgtcagct cagggctgaa gacacgtttt ccctttacac 3147241 attttcgaat ggcatcggcc agatcgtcaa tttcaccgtc tttcagcaga tagccatgtg 3147301 caccggcctt tacggcgcgt tcaaaatatc cggggcgggc aaaggtggtt aaaataatga 3147361 ccttgctgac gcagcctttt ttcattaatt cctctgccac attcagcccg cttcgaaccg 3147421 gcatttcaat gtccataatg catacatccg gctccagctt caaaatagca tgtagcgcct 3147481 cttccccgtt taatgcttgt ccgatgactg tcatatcctc ttctaaatca agcaaagatc 3147541 ccaaagcgcc taaaagcatt cgctggtcct cagcaataaa cagacgaatc attcttttcg 3147601 tcctccaatc attctgcttt tttaataagc ggaatcgtca gtgccacaac cgttccgtta 3147661 tggtctgaaa ccgttaatcc cccttcaatg agcatgagcc gttcttccat tccccacagg 3147721 ccattcccaa acattttctc cttcggcgct ccctttccgt catcccgtat tacgatcctc 3147781 attttgtcag caaattgaga aatggtgatg gcacagtggg ttgctttgct gtgcttgata 3147841 atgttagtca cggcttcccg catacacata ctgataatat tttgagtgac gggagatatc 3147901 actgaaaagt cgtcggctcc ttcgtattga aaggtaatgt tccccgctct taatatgtgc 3147961 tgaatgttta cgagctcctc tgttatcgtg accgttctca tatcagaaac cagctctcga 3148021 acttgcttga gtgcggagcg tgaactggtt tccatttctt ttgcctcaag cttggtccgt 3148081 tctggatcag atgcagccag ccgctgaatg agctggcttt ttaatgtaag cagcgacagg 3148141 gtgtggccaa gagtatcgtg aagatcacgg gcgattcgaa cacgttcctc ccttttagag 3148201 agttctttta tctgttcgtt ggcttgtgca agcttagctt caagctcaat cctccgaaac 3148261 atagaacgaa ttccgaatgg agaaatgagc ataatgacga gaaacgggag aacagaaaaa 3148321 agctcccgaa gcgagaccga attcgcgata aattggtata ggcatggaaa aagcagtata 3148381 aagattaaag cgcagaacgc acggttaaaa ttcgttttct ctttgtaata accaacaaag 3148441 tttgccggaa aaaaacctaa gtatatatag gtgatattgt aaaacacact atacatcaaa 3148501 ataaccgcca tttgcacgat aagccaatat gtaaacgaag ctttgcccac gctgcagaat 3148561 aactggcgat atgccgctac aaaaaggagc agcataccat atccgatccc ctgtttgacc 3148621 cctgattctt ttaataaaga gaggaacggc ataatcgtat acaccagaaa gatataaggg 3148681 aaaaacccga attccttcgg gaaaatagat attgcctttt tcatgtatta caccgcttct 3148741 tgttttcttc ttatatattt agatagtagc atgaagagca tcatataagc gattaatatc 3148801 agaatatttt tccaagtcgg actcccaccc cggacaagtt cccacgctcc gctcccgaaa 3148861 tgataagacg gaagccactg gccaatgctc tgcatcatgt caggcatgac ctcaaacggc 3148921 atccacatcc ctccgcctaa agccagcagc atataaagca cattactgat tccggccgct 3148981 gtttctactt ttctcatgag gccgattagt gtgcctaatg ctaaaaaagg caatgcgcca 3149041 aacaaaatcc acagtccgct catcatccat tcaaacggtg acaaggcaat atcattgatg 3149101 attgcgccga acagaaatat gacggtaatt gataaaacgt gaatgacact ttggccgatc 3149161 atctgagctg ataaatagat atgatccgga agaggcgtaa ggcggataaa ggcggcccag 3149221 ccttgtgacc gttcttgtac cattcggatg ccaagcgtca tgatagagga acccatcacg 3149281 ctgaagactg tcatcgacat caggtaatgg gcttcccatg cacgttgatc agggacgttg 3149341 gtattcacta catttgtaaa gaaataataa aaggcaatcg gcatgatcag agaccaaagc 3149401 acaaagtact tgttcctaag cacccttttc atttcagcga tgctttgctt ttgcagcacg 3149461 ttcactcaca tcgcctccct gttgccgtca gccagctggc gaaatgcctc atcgagcgtt 3149521 gcttgctcaa ttcgaatatc ccgtgcatgt atgttttctt gaaagatcag cgccaacact 3149581 ttgtctgtat ttgatgtctg gatgatggtt ctctcatgct cgtggatcac tctctcgact 3149641 tccgggtgac aagacagcct ttccaatgat tcacttgaat gaagcgtaaa ggaaacagac 3149701 tgtttttgaa ttcttgagcg gatttgcatt ggtgagccgt ctgcaacaag ctgtccttca 3149761 gtaaaaaata ggattcgctg tgcggcatca tctgcttcct gtaaataatg agttgaaaaa 3149821 ataatcgttt ttccttggtc cgacagtccg tgaatggtct gccagaatcg gtgtcttgat 3149881 gaagtgtcca tgccgactgt cggttcatca agtataagca gctccgggtt cccggcaaga 3149941 gccaaagcaa agctcaaacg gcgtttttgt ccgccggata atttttctgc tcttgttttc 3150001 aaatcttctt tggtgagtgc tgttaacgaa acgagttctt tcatggacaa tggattcgga 3150061 taatagctcc ggaagagttc aaggatttca tccaccttaa ggcccggcat gacacttact 3150121 tcctgaagca ttacacctat tttttcacga acctgttgat catcgggaac ccggttaaat 3150181 agtttgattt ctccctcact cggtttcagc aatcctaata tcatcgagac gacggtcgtc 3150241 ttccctgccc catttggccc gagaatggct gcaatttctc ctttttcaat actgaagctg 3150301 atgttgttta cagcggtttt tcgctggaaa tgttttgtca cgttgcttac tgttactgct 3150361 tctttcatca catgagcacc tcctgatcgt ttacattgat tgtaaaatga cggagaagac 3150421 gatgttagta tggggtgtca tgatgatgga gtgacaaatg tcattttttt ctcaccccgg 3150481 tgtctaggca atcctcctcc tgcatcttcc aattcatcca tcttttctat ctcccatgtc 3150541 ctctttcttt taaactgctg tgacattcat agaaagatac actcttcaaa ccatccgagt 3150601 gttatgatag aaatattgaa ctttatatta ctttccggct gaaaggagcc aatcatgaac 3150661 gaagcgattt tgtctagaaa tcatgtgaag gtgaaaggca gcggcaaagc atctatcatg 3150721 ttcgcacctg gttttggatg cgatcaaagc gtgtggaatg ccgtggcacc tgcctttgaa 3150781 gaagatcatc gggtgatttt atttgattac gtcggttcgg gacattcaga tttgcgcgca 3150841 tatgacctga atcgttacca gacacttgac ggctatgccc aggatgttct tgatgtttgt 3150901 gaagctttag atctgaagga aaccgtgttt gtgggtcact ccgtcggggc cttgattggg 3150961 atgcttgcat ccatccgccg cccggagctt ttttcccatc tggtgatggt ggggccttct 3151021 ccttgctatt tgaatgatcc gcctgagtat tacggaggat ttgaagagga gcagctcctt 3151081 ggcttgctgg agatgatgga gaaaaattat atcggctggg cgactgtatt tgcggcaacc 3151141 gttctgaatc agccagatcg gcctgaaatt aaggaagagc ttgaaagccg tttttgttct 3151201 actgatcctg tcattgcccg ccaattcgcg aaagcggcgt ttttttctga tcaccgagag 3151261 gatctttcga aggtaacggt tccctctctt attctccaat gtgcagatga tatcatcgca 3151321 cctgcaacag taggtaagta tatgcatcag catctgcctt atagcagtct gaaacaaatg 3151381 gaggctcgcg gacattgccc tcatatgagc catccagatg agacgataca gctgatcggc 3151441 gattatttaa aagcacacgt gtgatatagg aacgaaaggg atagaggtga ccctcttaga 3151501 tggacaaaca attgaatgat gcaccatgcg gtttcctcgc tttgtcagaa gaggggtcga 3151561 tcatagctgc caaccgcacc cttatcaaga ttctggatta tgaaccggag caggttatcg 3151621 gccagcacat gaatatgatg ttgaccattc ccgcgcagct tttctgccag ctttattttt 3151681 ttccgctttt gaaattggag catcacatcg aagaaatata catttccctg aaagcaagag 3151741 atggagaaga aattcccgtc cttatcaatg ctattgcgag acacgatagc ggggcttctg 3151801 tctttgattg tgttctgatt ccaatgcgaa agcgaaatga atatgaaaat gagctgctga 3151861 tagccagaaa tgaggctcag gaagctttgc ttgccaaaca gaaagccaat gcggagttag 3151921 aaattgcctt ggaaacgctg aaagcaaaac aagaagaact tcttgagatc aataaacaaa 3151981 atcaacaatt taaattaaac accaaaagag agcttgaact cgccagaaag atccagaaaa 3152041 actcgttgac tgaaccgatt gtaaacgatc aggttcagat tgactcttat tacaacgcat 3152101 cgagtgaatt gtcaggtgat ctttacggat attatcaaat cgatgaacac cgttacggca 3152161 ttattatcct tgatgtgatg gggcacggaa tttcatctgc attgattacg atgtctcttc 3152221 atcctttgtt ccagcgccag atcacgcaag gtctcagccc cgttaaagtt atgaaggaat 3152281 tggaccggca ccttcacagc ttgtttcaaa atgatgagga agcaagacat tattgcactg 3152341 ctatttatct cgagattgat atagcacggc aaagaattga ttatgtcaac gcagggcatc 3152401 cgccggcact ttggcaggac gatagcggaa ctcaacatct gcttcacgcg acctcgcctc 3152461 cgatcgggat gtttgaagac ttagagtttc agtcaagcag cctttcatac acggaggacg 3152521 gaagattgct tctgtatacg gatggcgtga tggatcctac ggcttcatgt tatttatttg 3152581 atttactaaa ggatcatcct gattcgccaa tcgctgacct gaaggagaaa atccttacat 3152641 cactgcagca tcaaaaggaa gctcatcata agagtgatga cgaatgtttt atattagttg 3152701 atgtaaaata aaatgatcca tgagacataa caatgatttg ttacatctca tggatttttt 3152761 tgtttcagcg tttctttgga atatgtcctg actccgcata ttgaaacacc tgcaaggaag 3152821 gcagcgggtg tccattaaaa tcaaataaag cttgattatc tacagcactt cccccatacc 3152881 acttcccggc gtcttcaggg tcgtattcag cagcatagct ggacgcccac cctgacccgt 3152941 atgtttccca taacactttg tttttctcta tctgtgtctt cggcccgact ggaatccacg 3153001 ccggctccca gtagaaaaca ccaagtcctg ctttgcccgt attcgccact gcctccatta 3153061 catctcttac tgcagttgcc tggccttgaa cagaaattgg atatggcaac gtctgcccgc 3153121 tttttggtgc tgtatttcca tgcccatcgc catcctcagc ggtataggtg tacgatgtct 3153181 ccgccaccat gacttttttg ccgtacgtat tggcaacagc cttcagcacg gaggtcaaat 3153241 tttgtaatgt gccatgccag aaaggataat aggagctagc aaacacatca taatccactt 3153301 tgtttttgct gagtgtttct gcaataaatg aataccttcc agccgtttca ggattggtaa 3153361 aatgcagggc gaccaaaata tttgaatttg tctccctgac cgctcggctt ccttcattaa 3153421 ataattggca catcttcgtc caatcagtct caccggcaaa tcctcctgtt gtttcatttc 3153481 cgacctgaac catgccgatg tcaacgcctt ccttgatcat cttttgcagg ctttgtttcg 3153541 tatactcata gagctttgct ttttttgctt caaagctgag attcgcccag gctttgggca 3153601 ccttttgttt cgctggatcg gcccagaaat cagagtagtg aaagtcggcc agcaccttca 3153661 ttccgttcgc tgtcgctctt tttccgattt cgatggcttt ttgaacatca ttgtttcccc 3153721 cgccataccc gttgccattt gaatcatacg ggtgattcca gatgcggacg cgaacatagt 3153781 tgaccccagc ctgttttaaa gttgtaaaga tatcctggcg ttttccgttt gtattgtaaa 3153841 aggtgacacc gctgttttcc aaagcaataa cgctggatac atctgcccct ttgataaaat 3153901 ccttgttcat cccctctact tttttaacaa aaagatcctc tgcccgaagc tctgacacgt 3153961 gcttctcctt ctcaatggca gcggcatatc ctgttgaact acatgcactc cacacgatgg 3154021 cagccgcaaa gaacattttc actttgcttt tcatgatttc atccccccaa gacttagcaa 3154081 gcgttttcat tctatagaaa aaagaatccg cccatatcga gcggagcatc agcctaatgt 3154141 gtgtttacga caattctcac ttcatacttt tccatcgtca ggtcgcctga caatatgtct 3154201 cctgtcatta tgtccttcac actctgatca aacgtgacca gctgtttttc ttccgtgaaa 3154261 ttcatgacaa aaatataatc attgtcctga tcctgcctcg cttgtacgga gacgcctttt 3154321 ccgtgccgaa ccggaaaaac tggagagaga gacaggtctg tgatcagacc ctcatagaaa 3154381 tcacgctgaa attgatcctc caaacgcgcg ccgataaaat acgccttgcc ctgctgatac 3154441 tcatggcttg tgaccgctgg cgtgcgcgca taaaaatctt cttgatacac cgcttccact 3154501 gaagctgtct ttacatcaat cacggttgca taatccttca tttcatatat ttggctgcgg 3154561 tagctgacag cgtttcgatc cttcggatac agggtgtccg tttcaagagg ctcaactcca 3154621 aatatagctt gaagatccgg atgccatccg cctgtgtatg ttaagtcatg ctcattcaca 3154681 accccgctga tatacgtcat gactaaggtg ccgccgtcag ccgtaaacgc ttttaaacgg 3154741 gaaacggtgt cctcgctgat taaatacagc atcgggacga tcagcagttt atatggtgaa 3154801 aagtcttgtt ctttcgtgat gacgtcgaca gggatatcgt gttcccagaa tgtgcggtaa 3154861 tgctgctgaa gcgtttgcgg ataacgtttt gtcgccttcg caaacccctg agcatcctcg 3154921 agcgcccaat gattttccca gtcatataaa atcgcggttt gagccggcct cttcgttccg 3154981 acaacttcgg acagccgttc caatgtctcg cctaccttgg ccacttcttg aaagacgcgg 3155041 ttcttcgggc tattgtcatg atccacaacc gctccgtgta atttttctga tgacccccgt 3155101 gatttgcggt attggaaata gagaacgctg tccgagccgt gggcaatcat ttgcatggat 3155161 gacagcagat tcatgcccgg gcgctttgcc ttgttgacgt tatgccaatt gaccgcgctt 3155221 ggcgtacact ccattaataa gaagggctgc tgcttcaagc ttcggtacag atcattgata 3155281 aagccgacct tcatcgccaa atcagctgtg ctttcccagt cattgtgcca gacaggataa 3155341 gcgtcccagc tgatggcatc gacatgcttt gcaaatttgc tgtagtcgag gccctgatac 3155401 gggatcaaat ccggtgtgtc agccataaaa ttcgttgtga tagggatatc aggcgtcaat 3155461 tctttcagcg gaatgatttc attttcataa aacgaaatcg tttgatcggt gacgaaccgg 3155521 cgccaatcta aattcaggcc atgcaagcca ttttcaccga tcggcgaagg gctttcaatt 3155581 tgtgaccagt cattgaacgt atggctccaa aaaggggtcc accacgcatg gttcaatgtc 3155641 ttgaggctgt tgtcatattt cgatttcagc cactcccgga aagcatgctg gcataaatca 3155701 cagtggcaat ctcccccgta ttcgtttgaa atgtgccaca ttaacagcgc cgggtgatgt 3155761 ccgtatcgtt ctgctaataa gcggttgatg tgccgtgttt tttctcggta gactttagat 3155821 gtgaggcagt ggttgtgcct tccgccgtgc agctgtttga cgcgggaggc attgacgcgc 3155881 aaaacttccg gataggtttg cgacagccag gccggacggg ctccgctcgg cgttgctaat 3155941 atgacccggc cgcctatact gtgaatccgc tcaaaaatat catccagcca ttcaaattga 3156001 tatacgccct cctccggctc aagtgcgctc catgcaaaaa tgccgacaga aaacgtattc 3156061 gtatgagaaa gcttcatcag tttgatatcg tcagctaaaa tatcgggccg atccagccac 3156121 tgatcggggt tgtagtctcc cccatggagc ataaattttg cttttgttac gtgcgttttt 3156181 tcaagctttg acatcacatt ctcctccttg ttctcttagc ccttcgttcc gcctgcggtt 3156241 aatccggaca caaaattctt ttgcagcata ataaagatga cggcaaccgg tatgctgata 3156301 agcagggctc cggccgcaaa tgtcgtatag ctggccccca tgacatcatt cactaaattg 3156361 aatagaccga cgggcaatgt atatgattca ggcgttctca atatggttga ggacagcaca 3156421 aaatctccga gcggaccggt aaagccgttc atggccacga ctgccgccat cggttttgat 3156481 aatggcagaa tgatctggaa gaagattctg gtgctgctgg ctccgtcaat cttggcgctt 3156541 tcgtctaaat ccatcggaat ggaatccatg taccctttca tcaaatacgt attcatcggg 3156601 atcaggccgc cgatataaag caagattagc agccagtggc tattgatcat tcccaagatt 3156661 tgcgccagca caaacaaggc aattaaagct gaaaactgag gaatcatctg cagcaataaa 3156721 aagagcgtta aagcgtattt cctcccttta aaccgaaagc gcgaaaacgc ataggccgta 3156781 aacgtcacac agagcaaaga ccctgccatt gtaaacaggc tgatcttcat agagttgaca 3156841 taccactgca catattgaag gctttccttg cccgcaaata attccttgta atgatcgaat 3156901 gtcggatgct tcggaatgat ggatgtactg attaagctgt tgccgggatt aaagcttgcg 3156961 cctgccgtcc aaaggagagg ataaacaatg atgaccgcca taaaggctag caacaagtaa 3157021 gagaaaagga gacggatata tcttctgact ttcatatctg ccagcatacc ttatgcctcc 3157081 tctttaaaag actttgtctg tctgaactgc cacaatgcga tggagataac aaatacagat 3157141 aataaaatgg ttaaagccgc agcaagtgaa tattggctgg actgcattgt caatttataa 3157201 atccatgaaa cgaggatatc tgtcccgccg gctgttgatc cggttacagc cggacctccg 3157261 ccattgaata gatagataat attaaagtta ttaaagttaa acgtaaactg agtaatgata 3157321 atcggagcca ttgcaatgaa caccatcgga agcgtgatgt atctcagctt tgaaaagaca 3157381 gaagcgccat caatcgtagc tgcttcatac agatcgtccg ggatggattg caatacgcct 3157441 gttgagacga gaaagatgta cggaaatccg agccagccct gcatgagaat caatgcaagc 3157501 ctcgaccaat tggcatctgt catccacgga agcggatcta tcccgaagaa agccaagatg 3157561 tcgtgattca tcgcaccgaa gctatcatta aacagtcccg caaaaattaa aatcgtcaca 3157621 aaaccgggaa cggcccatgg caaaatcaga atcgtccgaa aaaaacgttt aaaccgaagg 3157681 tctttctggt taacaatgat cgcgagaaaa atccccaagg tgacttgcag tgtggatgca 3157741 gcaagtgtcc aaaccaccgt ccaagccagt acatcaaaaa aagtcgacct ccaaatatca 3157801 actgtgaaaa tatttgcgaa cgtttgaaaa ccgacccaat caattaattt tgcaggagga 3157861 gaatgataca aatcatagtt tgtaaacgct aatgcaaagc tgaataagat aggaaagatc 3157921 acggcgaaaa ttaaaataaa caaagatggg ccgctgacga cataaggata gccctcagaa 3157981 atgatatgct ggtattgttc ctttaaggaa cttaatggct tattttcatc acgctgtttt 3158041 ccgctttgga acgcatcgcg aagatttaca taatacaccg caaggccaaa gcaggtcacg 3158101 atgacagcaa taatcccttc cgccagcaga aaaacggaat tatcccgcgg cacttctgtt 3158161 cccagtgtaa agattcccca aaaccccata ttgagcagat ctccaaagac cgcaaaaaac 3158221 gatgcgccta agaaaagaaa gacaatacct tttatccatt gcttgttata aaattgcccg 3158281 agtcccggaa tgatagaaag caacaaagcg acttgacgat gctgcaccgt tttcacctct 3158341 cttacaatac aaatctagct ttctctttat tttccgctgt gctttgcctt aatttgtcct 3158401 ttggccgttt cagctgcttg atccaatgct tgtttcggat ctgccttccc tgttgcaacc 3158461 gtctgtaatg ctgaatcagc cggcgtccat atttcattca tttccggaat atttggtgtt 3158521 ggctctgaga aacgggattg ttcagtaaca gcccgtgccg cctcgctttt cataatagcc 3158581 gggtcattgg ctagggattt cacagcagga acttctttcg tttcttcata tcgtgtttta 3158641 gaattttttt catttgccag gaaaacggct aattcttgcg ccagctcttc attctttgaa 3158701 aatgcactga cgttgtagct tttgacgccg ataaaggagc tcatgttttt cccattttcc 3158761 agcttcggca gtttcgtaat gccataattg attcctgcat tcgaaaaggc ttctacattc 3158821 catggaccag aaataattgc ggcggctttt ccttctgtga acagcgattc caacacgtta 3158881 atcccttgtt ctccaataat gccagccggg aacaggccat ctttgtaaaa cttctgaatc 3158941 agcgccgcac ctttgacagc tccttcatta ttgattccaa tgtctgacgg gttatagctc 3159001 ccatctttgg cctttccaaa aatgtatccg ccatatccgc tcatcacact ttctgcataa 3159061 taaatttgat cgaatagggc taaaaagcca aatttgctgc cgtcagcagt ctttttggaa 3159121 tagtcgtacc actcttccag cgttttgggc aattcctttt ctgtgatgag atctttgttg 3159181 taaaaaagca cagtcgtttc gaccgctttt ggcagtccat aaagcttttg atctaccatt 3159241 tgagactgaa tggaagcgtc agtataaagt gattgaacgt cttttttgac atgtaattcc 3159301 ttgagtaatc cttccgtgac agcggttccg atttggtccc ctggcattgt taacacgtca 3159361 gggcctgtgc cggccggtcc atccattcgc aaatcttcaa tctgcttggc atacggtttt 3159421 tcaacgactt tgaccttcac atcatgctct ttttcaaatg cagccacagc gtctttaatg 3159481 ccgttgctct tttctttatc ctcccataca acaagctctg acccttttga actcgatttg 3159541 gcgctgctgc tttcctttgg gccgcaagcc gccaaggata aactgacagc tgcgcagagc 3159601 atgaatacgg aacacttttt tgccattttc attgattgtc accctttcgg taggaatgaa 3159661 agcgctttaa agataatata gcatgcctga gaaaatgtgt aaacaaacta tttacttcat 3159721 agagtaaatt tttttaccta aataaaaaat gacttagtgt cctaagtcat ccttaattca 3159781 tactcttcct gacgattaat tctgcgccca catataatgt ttttaccgtt cttctcttgt 3159841 cctgcacttg ttcaagcagt aattgaacag cgtttttaca taattcatgt atatcaatat 3159901 gaaacgtcgt cagaggaggc gagacatact tcgcgaagct gatgttgttg atactcacaa 3159961 tgcttaccct gtttggtatg gcaattcctt tttcgttcag ggcttgcaga cagcccactg 3160021 caatcgggtc cgctgcaatc ataaaagcag tcggaagctg atcgcctaat gtgtcgatcg 3160081 ctgctgacat caggcggtag ccgttttcta cagagaatcc gcgatgacag aaaatatagc 3160141 gctcgtccag catggctttt tccctcatat aggatctgaa ggtttgttca cggatgtcca 3160201 tttcatcctg attggtattc ggatttttgt atgtgccgcc gataaaaccg atgctcttat 3160261 gccccttctc agtcaggatg tttaccgtct tccttgtcat ttgtgccaaa tcgggcctta 3160321 ccgagtcaaa atgatcggga tcaggagttg aatcgatgaa cacgccgttt tcagtgagat 3160381 ttctgaggaa agccagctct tcatctgaaa atgtgccgac ggcaataaac ccttccgtat 3160441 gttcaggaat gctctcgatt ccatccgcta ttttataagt ggtcatatcg acattgaatg 3160501 ctttcgccag tttctctact tctaatctca tcgttttaaa atagacatct tctaattctt 3160561 ctttatctgt cagccaatat aaaaacgcaa tatgtttcac cagcggcctt actgtttttt 3160621 tgcggtaatt gagcttttcc gccgcttcat agattttctc ccgtgtctca tcaggaacag 3160681 aaaggctttc atcgttattt aaaacgcggg aaacggttga gattgaaaat cccgcttcct 3160741 gcgcgatatc tttaattgtc gccattgtat ctgcctccat tattcagctc gcattgtttt 3160801 agtaaaatat tttactttct ttttcacaaa tgtcaagtgc acaaagccct ctggctgcca 3160861 tgtaaaaaga ctgaaccatt tgcggctcag tctcagttgt tcgtatcatt cggaaccggc 3160921 ggaattgccc gggaaatgag ttggttattg cacattttcc tcgaaatatc ccgaaagcac 3160981 atcttccaca ttcgtcaaat gcgccagcat ggcggcttcc gcctgtgcac cgttcccggc 3161041 agccacagca ttgtaaatcc gttcgtgctc ctcatacagc cgctgaacgg aggtcttctt 3161101 ggaaaacagc cagattttcc tcgtttccct cattgtttcc agcagcaatg atgacacgtg 3161161 attcatcaag tgtttaagaa gttcattttg agaagcgtcc gcaagcgcaa gatgaaatgc 3161221 aaagtctgct ttctctccca gctccccgtc cgcttcaatg ctgcccattt cctttagtgc 3161281 atcctgaatt ctttcgagat ctgcttctgt ccttttttca gccgctagtg aagccacgcc 3161341 gatttcaagc agttttctga cctcgagcag ctgcttgacg tcctcttttt tcatcagaag 3161401 ggcggctgag agcggctgag aaatttgatt gagctcaaat tccttcagat acgtgccttc 3161461 tccctgtttc atttcgacaa gccccatcgc ttttagcgca gaaagtgctt cgcgaaccgc 3161521 tgaacggctg acttgaaagc tctcagcaag cgcctgaaca gagtccagtt tatcccccgg 3161581 cttcaattcg ccatttttga tcatatctaa tagggcatcc gctacttctt catatatttt 3161641 tttgttttaa tctgtttata tttcaatgca attcaccccg taacttgtag gtctggctgt 3161701 ttacgatcta ttatactctg ttttgtgggc cgccaaaaga ttttgactat tttgtcaaaa 3161761 agtcttgtac tttgattttt ttcaaaatat aatgctaggt aactggtctt attacccagt 3161821 catcagatga tcatatcatc tatagaaacc gcttacatat ggcgccagtt tatgtttcaa 3161881 ggaggggttt gggatgcaat ggacacaggc atatacgcct atagggggaa atttgctatt 3161941 atcagcgctt gccgcacttg taccgattat tttctttttt tgggcactcg cgattaaacg 3162001 gatgaagggg tatacagcag gcttggccac attggggatc gcccttatca ttgctgtatt 3162061 ggtttatcgt atgccggcgg aaaaagcgct gatgtccgcg acacaaggag ccgtatacgg 3162121 attgttgccg atcggctgga tcattgtgac gtctgttttt ttgtataaaa tcactgtgaa 3162181 aacgggacag tttgatatca ttcgcagctc tgttctctcg attactgatg accgacggct 3162241 tcaagctctc ttgatcgctt tttcattcgg ggctttttta gaaggggcag caggcttcgg 3162301 agcgccggtc gccatttctg ccgcgctgct ggtcggtctc ggctttaatc ctctttatgc 3162361 tgcggggatc tgtttgatcg ccaatacggc gccggttgcc tttggggcaa ttgggattcc 3162421 aattacagcc gtagaagggc cgacagggat tccggcgatg gagatttcgc aaatggttgg 3162481 gcggcagctg ccgtttttat ccgtatttat tcctctttat ttaatcatca tcatgagcgg 3162541 gttcaggaaa gccttggaga tctggccggc gattctcgta tccggtgttt cctttgctgt 3162601 tgttcaatat ctcagttcca attttttagg gcctgagctg cccgatgttt tgtcagctct 3162661 tgtttcaatg gctgcgcttg ctgtgttttt gaaatggtgg aagccgaaaa caacattccg 3162721 gtttgccggt gaacaagagt cggccgcctc aattgaaacg gcgcgcacaa atccggcggc 3162781 gcctgcatac agaggcggac agatttttaa ggcttggtcg ccatttctgc tgctgacggc 3162841 gatgatttcc gtatggggca ttccatctgt caaatccgcg ctgaccgggc attatgaagg 3162901 ctctgcggtg ttcttgaagt ggctgaatgc tgttggagaa aaactgactt tttcccccgg 3162961 tgtgcctttt ttgaacaatc agattgtcaa tgctgacggt acgccgattg aagcggttta 3163021 caagttggag gtgcttggtt cggccggcac cgcgatattg attgccgcag tgctgtcaaa 3163081 attcatcacg gcgatttcgt ggaaagactg gggaaccgtt tttaaagaaa cagtccagga 3163141 attgaagctt ccgattttga ccattgcttc tgtcgttggt tttgcctatg tcaccaactc 3163201 ctcgggaatg agcacgacac tcgggatgac actcgcgctg acaggttcga tgtttacctt 3163261 cttttcgccc gttctcggct ggctcggcgt cttcattacc ggctcggata cttctgccaa 3163321 cctgctgttc ggcaacctgc agaaagtcac cgcattatca gtcggcatgg accccgttct 3163381 gtctgtggcc gccaactctt caggcggtgt cacaggaaaa atgatttcac cgcagtcgat 3163441 agcggtggcg tgcgccgcgg taggactcgc cggaaaggag tcagatcttt tccgctttac 3163501 cattaaacac agtctgtttt tgctgctgct cgtctgtatc atcacctttt tgcagcatca 3163561 cgtattcagc tggatgattc cttaaaaaaa tcctcccgtc tagggaggat tttatttata 3163621 tcgctttctc gctgccgatg acggaatatt catttgatcg cgatattttg ccacggtgcg 3163681 tctcgagatt tggatgccgt gttgttcata cagcaaatcg acaagctttt ggtctgaaag 3163741 cggttttgtt ttgtcctctt gattgatcag gttttccaga tgcgttttga ctgcataatt 3163801 cgacgcatct ccatcacctg aagcctcggc ttttgctgag aaaaagagtt tcatctcaaa 3163861 cagcccgtaa ggcgtttgta ttgttttccc tttaatggcc cggctcacag ttgattcatg 3163921 aaggcttaga cagtctgcca cctctctgag agtcagcggc ttcattgcgc ttcgcccttt 3163981 cagaaagaaa tccttttggc gtgtgatcag ttcattgata attctcgtga ttgtctgttt 3164041 tcgctgccgc agcgcgcggc tcagccagcg ccactcctga tatttcgcag ataaatagga 3164101 gacagtatcc tgacaggagc cggatgataa aagcgttctg tactgcggat gcagatcgat 3164161 ctcgggaaac gagcgggtat tcagttccgc tgcgatgtgc ccatttttta cggtgataaa 3164221 aatgtcaggc tcaatataca catcttgctc tggccgggca aacagaaggc caggtctagg 3164281 atgaagagcc gcgatatcat ctgagatatc ttgaatggta tgaagcggaa ttcccgtctc 3164341 tactgaaagc gttttccatt ttttttgcgc aaaagcatca aaatgagctg aaaccagcat 3164401 ttccgcttgt tcatttctgt tcggcagccg ctgtaattga agaaggatgc attcctgcaa 3164461 agatctcgcg ccgattccag ccggttctaa cgactggagt tttgccaaaa cagcctccgc 3164521 ttccttggcc gatacagata atcgccgtgc tgcctcctct atatcttctt ccaagtaccc 3164581 gtttgaatca agcgaatgaa tcagataatt aaaaatcttt ttttcagtgt ttgtcagatt 3164641 catatcgagt gactgctgtt ttaacgcatc ctgcaatgtt ttttgcggat tacttaattg 3164701 aaggcccgct tcctgtgcat tcatcctgtt tttgtttgtt ttatggtaag atagtggcgg 3164761 tgtgtctgtt tcctttcgtt caataagagg gttttccagt gagagctcat caatgtactc 3164821 ggcgagttct gccgaatgat agccaagcag cgtgatggcc tgcctgagct cctgtgtcag 3164881 ttgaggcttt aatacttgta cttgctgaag tttcatatcc atcttgctca ctcccctttc 3164941 ttcattgtac atgattgaga tcacaccgta tacatttatg aaaaaggagc tgccaaagaa 3165001 atgtctgaac ttttttccgt cccttatttt attgagaatt taaaacagca tattgaaatg 3165061 aatcagtctg aggataaaat ccacgcgatg aacagctact accgttccgt cgtctcaaca 3165121 ctagtgcagg accagctgac gaaaaacgca gttgtcctga aacggattca gcatttagat 3165181 gaagcataca acaaagtcaa acgtggagaa tcaaaataaa ccttccgctc acatgtgagc 3165241 aggaaggttt tccttctttg aggcgtgctg gatgagacgg gtgcttggca cgccttccat 3165301 ccaggtatga aagtaattgg cgtttttccc gtaggaatta tcaatgaccg tgttttcttt 3165361 ttgaagaaga gaagacagga tgtggccgtg cagccttgat gtttccaccg attcgtaacg 3165421 gctgaaaaac cgaatcgctt tttggacgat ataatccgag tatttttccc atatatacgc 3165481 aatgggcaaa gggttgcctg cttttttatt caagacgttc agcgtttgga gaaaagcaat 3165541 cgtccggcgg tctgaagctg acagcaccgt gcgccagtcg tagctttccg cttctgcgtg 3165601 ttcctgaagc gcctggtttg cttcatgatc tgttcggata aatctcagct tttgattgga 3165661 cggctgctgc gtgggaatga cgggaaacag ctgatgagcc atatcaggca gaagctgaat 3165721 gtgatttgtt gtaaaatagg cctgtgccgt agcataggag gctttttccc ttgtcatgat 3165781 gtgaaggttc gcatgcttag aaaatatctc tgccgtccgc ttgaggttgt ctttgttttg 3165841 aaaataaatc gattgcggca ggatcacaat tttgtggttc ggataggttt ggacgatttt 3165901 ctctctaaag ccttgataat acggatacag atccccgaag tttccgcctc cctggcagac 3165961 gatgatgaga ttcggatcaa gctttcgccc gattgggaaa ttgtctggat tccagcgttt 3166021 tctgacccga atcccgtgtt ctttaaagaa ggcttctgtt cctttcataa taaataaatc 3166081 ccctacattc ccatatagag gatagtcagc atatataatc tctgattgtt tcggaatgac 3166141 gtcgagcagc ccggacagtt tctgtttcag gctgatcatc gaatgcttgc tgtccatttc 3166201 ttcacctcga cagtatggaa taagtgcagt agcacttcaa tgacccggcc ttgctcatct 3166261 tctgtcatat tggaccccga tgggagacag attcctcgct tgaacaaatc ttcgcatacg 3166321 cttcctgtat cttcatgaga ataaaataaa gccggatcga acagcggctg ggtatggagc 3166381 ggcttccaca gcggacgggc ttcaatgttt tcttcagcaa gacgttgaac tatgtcatat 3166441 gggctgagcc cgttatcaag tgtgagcgtg gtgagccagc gattggatac gcctgctgcg 3166501 tactctggca taaagcggac gccgtctaag tgaccgagcg catttttgta tctcgtgaaa 3166561 atggtccttc ttttctccac tcgctcatcc agcacctcaa gctgggcaat gccgacgccg 3166621 gctaagatat tgctcagcct gtaattatgt ccaatttcac tgtgctgata atgaacagcc 3166681 ggctctcgtg cctgcgaagc gagaaatctt gctttttcaa ttgcggcttc atcatttgaa 3166741 acgagcatcc ctccccctga tgtggtgatg attttgttcc cgttaaatga aaaaatgccg 3166801 aagcgcccga atgttccgct ttgcttccct ttatagactg tgccgagaga ttcggctgcg 3166861 tcctcaatga caggaactcc gtatgcatca cacaggctta cgatttcatc cattttcgcg 3166921 ctctgcccat atagattgac ggcaattacc gcttttggca gtgttccgtt tcttttcgct 3166981 tcctccaatg ctctttcaag ggctgtcggc gacatattcc acgtatcagg ctcagaatca 3167041 ataaagacgg gcaccgcttt ttcatataga atcggattgg cggttgctac aaatgtgaag 3167101 gactggcaaa acacgctgtc accttctttt acctcaagca aacgcagcgc gagatgaatc 3167161 gccgccgttc ctgagccgac cgcagctgct gcttttacac cgactcgttc tgccagctgt 3167221 tcttcaaatg aattcacgag cggcccaagc ggcgcaatcc agtttgagcg aaaggcttct 3167281 gaaatatagt gctgctccct gccgctcata tgagggggag ataagtagat ttttttatgc 3167341 atagaatcat cctttgtttg atgtttgaat ggaagaaatg atgcgtgccg gagcaccggc 3167401 cgccgttacc ctgtccggta tggaacggat caccgcggag ccggctccga caatgctcca 3167461 agccccgatt atgatctgcg gtatgacgga tgcaccggtt ccgacgtgag cgccttcctg 3167521 aacggaaacc gctcctgaca gcgtggcacg cggggacaga tgaacgtaat cgctgatttg 3167581 attgtcgtgc tctgccactg cacccgtatt gatgatgcag tgggcgccga tgcgcgcatc 3167641 cgcctgaatg atcgcgcccg ccataatcac tgtcccttcc ccaatgacag ccgacttgct 3167701 gacgatggct gacgggtgaa tcaatgtaat aaaatcatct ttccccagtc ccagtcgctc 3167761 cgccagctgt tttctgacac tgttattccc aacagcaatc agaaacagca catcaggaat 3167821 gagcctgcgc agttcagtaa cggctttcgg cggtcctgtg taccattctt ttccgccttc 3167881 gaacgttttg aatttatcat ccagcaccgc ggctaagcgc gtatctgagc gggcgtttat 3167941 cagctctctg atcacctttc cgtgaccgcc gtcacccaca atggccacat ttttcatgag 3168001 gacacatctc cgcttccggt aaaccgttcc gcggtcacat gattggtttg ctgaatccct 3168061 tctgaaacaa ggacctttcg caccgtcaaa cataaaattt tcaaatcgag aaaaaatgac 3168121 cagttgtcaa cgtaccaaac atctaattca aatttctttt cccaggaaat cgcgtttctg 3168181 ccattgattt gcgcccagcc tgtgataccc ggcttcacct catggcgccg tgcctgtttt 3168241 tctgtataaa gaggcagata gtccatcaaa agcggccgcg gcccgacaag gctcagatcg 3168301 cccttcagga cattcaggag ctgcggaagc tcatcaatgc tcagctttct gatcagcctg 3168361 cccgttttcg tcagccggac ttcatcaggc agcagatttc ctttactgtc ccgttcatcc 3168421 gtcattgtcc ggaacttata tagggtgaac ggtttgccgt gcaggcccgg ccttacttgc 3168481 ttaaagaaga caggtgatcc tattttcagc ctgacaacgg cgatggtgaa cagaatgatc 3168541 acacttgtac agcacaacaa aaaaatggcg gccgtcagat caaaaagtcg tttcaggatc 3168601 aaagattcac agctcctttc gtttttcgaa accgttttaa taccagctgt ctttcctctt 3168661 ttgtacaaac gagcataaaa gcgaaaacag cgtagcaaaa gctgactgtc actcccgtcg 3168721 ctatcaatga cggccagctg tcaatcttca caatgaactg aattgcctta cagaccgtcc 3168781 aggcaaatac agcggctgaa agaggcccga ttatgccttt aaggaacacg tgctttttgt 3168841 agcctgtaat gcgggatacg taaagcggcg taaagatggc attttttaaa ataagagaaa 3168901 tggcccctgc caatgttatg ccgtacagac cgagatgagc cggcccgctc agcgtgaccg 3168961 ccagcaccac attcaccgca cctaacagca gggtaacaat cgccggtgtt ttttgttgat 3169021 taaaagcggt ccatatataa aacagcggca taaaggcgag gctgacaacc aagtatccgg 3169081 catgaataaa taaaagcggt gctatcgttg aaaaggacgg tccgagccag attgtcagaa 3169141 aaggtcccgc caatccgccc aataaggcag caggaagtgc aagcaaaaga ccattgagcc 3169201 ttactgcctt attggcgtaa ttcatcaatc cttccatatc gccttttgaa taatatgaag 3169261 tcatgatggg cgcaaacagg gatgcgaccg ttccggccaa gctgcgcaaa agcagcggaa 3169321 actggataat cgccgcgtat ttcccggatg cagacgcccc cagcatcaaa ttggcggtta 3169381 acagatcaat ctgcaaaaaa agcaggacgc cgatttgatt gacggagctc catgcgcccg 3169441 cttgaaacag ctccttgctt gtacggaatg aaagatcctt catacgaaac gaaaaccacg 3169501 gaatcagctt tttgaagaaa tagaaagaca gcacagacgc aataacagca ccagctaaag 3169561 ctgcaagctg gatctgccag attttcggcg caaagcatgc aaacaggagc agcacagaca 3169621 gcacccgtat aagcatttgc accgcctgaa tggaactggt gatataaagg cggttggcat 3169681 aaaatggtgc agcgccgaag cccgccatca gaaacgttaa aataaacagc acactgccga 3169741 ttaaaatcga caaacgcaca tctgccaaaa gcgcttgcgg cacattcatg acgcggtcaa 3169801 taaaaaaagc cgaacccgca agcggcagca agagcagcaa ggaaatcaaa acagaggcgg 3169861 ctaaataatt gctgatatac gcatttgctt tctcccgctc tcccctgtgg gcagcaacag 3169921 aaaagaaccg aacgacaacc gagctgagcg ccacggtaat aaccgaaaag taattaatca 3169981 cattttgtgt caagtgaaca aagccaaacg cttcgacacc gagcgttttg acaataaaag 3170041 gcgtcatcca aaccgatagg aaaacagaca agagaaaagc cgtgagattc gcgctgaaat 3170101 ttatcgtgaa tttcatgcct gcttcgcact gcctttcatt gtcccccgct gctcgaaaaa 3170161 cagcttgatg agaaaagtga gccgccattt acacagtgct aataccaaac gctctcctct 3170221 taataatttc tcatgctgaa acggtgtatg tctgacagcc tgccgcacca tgtcatagga 3170281 taaaatctgt ctgatcttct ttttgatgtc tttcggcgaa ttcggagaag cacaggcatt 3170341 tgccaaaagc atcggaagct ggtgcctgca aatgtacaca ttcaaatctt ctttacatgc 3170401 gcctgctaag ccgtagtgat tgtagaatgc gattttagcc tgatattgtt tttgaagatg 3170461 ttcatccatc gccggcttat aagggatttc tgtcaggctg ttcgggtttt cacgataaat 3170521 gtacaatcct tcatcaagca ttttcacccg ctccgcttcg cgaaaagcgg acaaattaaa 3170581 gggagagtct tcagcaaaac ggatgtcttc atcaaacagc agattcgccc tttcaaaaag 3170641 ctcacgacgg taaagataac gccatacata ccagataaat ctcgtttcgt gagcatgttt 3170701 aagctgttca gtcatttctg gtttcgtcag cacgcggttt gcctcaagct gcggcggcac 3170761 atatgtccgc ctgtccgatg actgcttgta aaaaccgcat ccgacgatgt caagctgatt 3170821 ttgctccgct tcttcagtca gcctctggaa catggcggat gatacataat cgtctccgtc 3170881 tacaaagccg atgtaagtgc cccgcgcggc ctttattccc gtatttcgcg ctgaactaag 3170941 cccgccgttt gcctgatgaa tgacccggat tctcgcatcc cgttttgcat agtcctctgc 3171001 aatttcgcct gaacgatccg gtgttccgtc attcacgagg atgatttcaa tatcagaaag 3171061 cgtttgacga agcaaagaat caatgcactc ttctataaat ggttcaacat tatacatcgg 3171121 gacaataatg ctgacgagcg ggatcattgc gcttcaccgc tgattttgtc acgcagacct 3171181 ttaaaataca catctctcgg aaagcctgca cgggatgttt cttttgttaa aagctcattg 3171241 actgcggctg ttacgcgctc tggctccgga tgttctatca gcttcatgaa cgggatgtct 3171301 ttaagccatt gatagccctc catcacctta tggtcaaagg agcgaatgac aacacacggc 3171361 gttcctgtca gcgcgcaaaa aatcatgcca tgaagcctgt cagtgacgac ggcttctgcg 3171421 ctttgcagct tagaccacag tgcttcaagt tcatgttcgc gtgtatcgcg gctgacccgg 3171481 cggccgatcg ttgtcgtaaa ggatttgatc tcgccgaatt cctcacatag cgcagccttg 3171541 acccggttcc tctgctcctc ctgaagcacg ctttcctgat cctcgcgcaa acacatataa 3171601 accccttcgc gttctgcggg agccttgctt ctgtctaaat acagcaccat gtccggctgc 3171661 ttcaaaattg ttttttcttg aaaatgctgt ttcataaatt gatacgttgt ttcatcccgc 3171721 gccatcagca ataggccggg gtgcgcatta taaattttct gtgcccgttt cagctctttg 3171781 cgcccttttt tcgtgtcaga aaaatgagcc gttgccggaa gctggacaac ccgatagtca 3171841 tggaatgttt taatgatgaa gcggcgcgtc cactcctcat aacggtataa atcccccatg 3171901 tttccgccgc cgatgataaa gaccatatcc tccggatggc gcgagcggat caggcttttt 3171961 gctgatttgt aaatgtcctt catatcgacc tcgacgatgt caaagtccgg gtattcttgc 3172021 tcaagaaatg ccttgctggc ataagcaatt gcgtgatctc ccaaattgtc atgggacggc 3172081 agcagggtca gtatgatttt tttctgatgt gctgcggcct ttaccggttg atctgccgct 3172141 cccagccaat attgggacgg gtatttgacc tttagcagca gccattctgc aaaattgatt 3172201 ttcaacgatt gtaacgacat gtcctcaccc tctgtttctc attttgtact cgatcacccg 3172261 ctgatacaca gccgatgcca tagcgacgaa cggaatcatt ctgtatttcg ccatcagaag 3172321 caggcatgac cgttttgcgt caaaaggagc agtacccgtt tttgaaagac tttcttgaaa 3172381 caccgggtcc gcgcatatca cgccaacatt tctaagcttt tcaaacagcc ggcggctgcc 3172441 gctcgttttc cattcattca gcatacagat gctgctgtga agaacgataa aggtatcaag 3172501 ctccttgcga tactcctcca gtttgttgtt ctcctgtaaa aacgccgcat tcgtctcata 3172561 cagcgcaagt cctgattcaa acaatttttt ctgatagcgc tgcacaatgg aggaaaggtg 3172621 aattcgataa tgatagagcg gcgtttttac gtaggatact gagcgggcga aaaaatgagc 3172681 cctgaagctg aaaaactgat cctcgacatg ctccagctcg cctcggagcg gaaacgacag 3172741 ccgatgggct tcaatcatgc ttcttctgta cagtttgttc catgaaaacc ctctgacctt 3172801 cccttcgaat aacgccttga tatagtgctc cttcggctga tcctgatagg tttgggcaat 3172861 gtcagagtcc atggttttgc cagtgtcctc aaactctgcg gcgtaattgc aaatgaccag 3172921 atcagtttca tcgcctgctg tccggagcat ctgctcgcaa taatcaggct caatccaatc 3172981 gtctgaatcg ataaacgcga taaattcgcc gcgtgcagct tcaatgcctt tattccgaac 3173041 cgcaccgagt ccctggtttt cctgatgaat caccttgaac ctgttgtcca ttttggcgta 3173101 ttcttctgcg atatccgggc tggcgtcagc tgaaccgtca ttgacaatga tgatttcaat 3173161 attgtccatt gtctggttcc gcagtgattc gagacacgtt ctgatatatg tttctgtgtt 3173221 ataaacagcg actaacagac taaccgcagg tgtttccata atgaccggct cctcgtgcat 3173281 aaattaccgg gaaaaaatcg ttctgtaagg cagaaccgat gaatcgaccg gcataagcaa 3173341 ataactgtaa agaaaataac aaacaacgat agcgatatag ataagagcgt tcgatttttc 3173401 atcaaatatc ctgacgaaat aagggactag gatcatttga tacagaccga aataaatatt 3173461 gaatctggca aaaatcacgt cctttgtggc caaaaggccg aacaaaaaac ctagcaggca 3173521 caaattgacg acaatatcaa tttgcggcca cagactccgc agtcgttctt tatagcaaaa 3173581 tgcaaggaac agcggcagaa ccaaaacagc gattttgatc acattcattc catttgtgtt 3173641 cgtcatgagc catttttcat aatggctgta tgagctgttt tcaagtacaa cgacaaacac 3173701 agaaataaat ttttgatata aaaatgtcat gccgagaaat aaagcggata ggccgaatat 3173761 cgccggtgac caggcttttc ttctgacaat aaagtacact ggaatcataa tcagcgccga 3173821 cgaatgaaag agcgagctga ccagcacaat caggaaatat cgcttccagt tcccgctaat 3173881 gatataacgg atcgcccaaa acaaaacagc tgccaccatg tattgcctga tgccgttaaa 3173941 agatgcgtaa taatgaaagg ttcccaaaaa taaaaagaca ctcagctcaa acggcctgcc 3174001 atagtcggcg agtgtcttca taataaagct gtaggtcacg accgccaccg taaaatacat 3174061 gatttgagga tcttccgtga tgaaattcat cagccaaagg agtgcggtaa accccggatc 3174121 tgtcgctgtt ttcgctgtgc cgaaaccgaa tatctgccac acattttgat aatcgcccgc 3174181 caattcgtac aacagcgtgt acgtctgaaa atccgtgccg actcgatagc ggagacctga 3174241 cacgagcaca agtgaagcga gcggaatcca gatcaaaagc ttattcggcc gataccccgt 3174301 ggcaagcgaa tcatcacggc cgccgcacat tttagcgaac caagaccaaa taaatacaat 3174361 ccccatattg acggcatata caatcatcgg ttatggtcct tttccgtgct gatgttgtat 3174421 acattcagca gcgctcctac attttgctgt gcatcgtagc caagttgagc gagtgtttct 3174481 ttgatgaact cacgcttcgg cctgcctgcg gcggccgccc ttgcaatggt ttcagcccag 3174541 acgctgatcg gctcagaaag acttaatctt gtgacaagcc cgagaccggc gtcgactttt 3174601 tctgtaatgc tgtctgaaat gatgcatgga agccccgacg cctgcgcttc cacaagcaca 3174661 accggcaagc cttcgtacag agacggcatg acaaatacat cgaatgttcg catcagttca 3174721 tggatccgtt cttccgtgcc taaaaagagg acgtctgata gcaaattctg ctgccgcgcc 3174781 tcctcctcta tctccccgca caacggcccg tctcccgcca gaacgagctg aaagcgaatg 3174841 cctctttcct tgagatgtgc ggcaagcttc aacaggaacg cgtggttttt cacttcatga 3174901 aaccgggcca catggccaat gatgagccgg tcggctgcaa tgccgcgtgc tgctttttct 3174961 tcatcagccg cctgcccatt tggggcgaac aactcaaggt caatcccgtt aggaagaagg 3175021 tgaacacgct cccgctccat attggactgt ccaaataaaa acctgcccgc atcctctccg 3175081 caggcacaca gcgctgtcgc atttgccaaa atgagccgcc tgaacacgag cagctgcaat 3175141 cgatccttcc agttgaagcc ggtcttccaa gacgtattgt gggagtggca taccctgacc 3175201 ggcactccgg cgagccttgc cgcaagggcg ataaaacccg tttggaaatc cgtgtgcgca 3175261 tgaacggcgc tgaacggccc attttctttt atcgcgtttc tcacattcct cacaaatgta 3175321 aggggattgc tttgcccaat gctcgggaca taaaaaagcc gcccgcctaa agataaaatc 3175381 tcttcatcat aagcgcacgg atcatttcga tacgttaaaa aatcaaattg cactttgctt 3175441 ttgtccatct tccgatataa attcattacc atggtttccg cgccgcccct gttcatgccg 3175501 ctgagaacat ggagcacgcg cttttggctg ctattcatgc ttgacaagcc cttccttttg 3175561 gttcatcact ctttttttat ggtagcgatt catcacagct gcaggcataa aggcgcgaat 3175621 taacggtttt gcgatatata tgtaatcaga taaaggaagc ttcaagcgtc tgcacgcctg 3175681 atagacaaga atggcattgt cgattgaata cgtaaatgac cgccgtttga atgcatcgct 3175741 gtcttccctc actttataca aggcttcctg aagattatag cccctgaagc cctcttcaaa 3175801 aaagcgaagc cacaaatcaa tatcttccat tcgtctcgtc cgccgcaccg accggtagcc 3175861 tttcagcgtg cggtaggcac tcgctctcat cataatcgtg ccgtggcaaa atggagtccc 3175921 ttttgccatg atgcccggct ccggaacaga aggcagaatg cgggcgcctc ttacgccaaa 3175981 ttcatcaaac acaagcatgc cggtgccaac cacctgatag tgtcggtgct tttctaaaaa 3176041 cgcgacctgc ttttccagac ggcgcggaaa cgaaaggtca tctccgtcct gacgtgcgat 3176101 ataatcgcct gtcgcatgcg aaagacaatg atttaatgat gcggcaagcc gcttatttgt 3176161 tttgttttga atcagtttga tgcggtcgct gtaatgagcg gcatactgct tcgcgatacg 3176221 gagcgtgccg tctgttgacg catcatcgca caaaatcagc tcccaatttt tataggattg 3176281 gctgagtatg gattctatgc tttctgccaa agtgcgttcg caattataaa tgcccataat 3176341 gacagaaact ttcggtcctg agttcatacg cttttctcct ttgtatccat atccatgtac 3176401 gcggaataaa tatctgccat ttcttccacc gttcgcgcct ccgagaagcg caaggctgtt 3176461 tttcggcctt cctgtcccag ctttcggcag agctccggct tatggtaaag ctgttcaatc 3176521 cggcgggcaa aagcagcact gtcaccgatt ttgatcagaa aaccgttttc tccgtcgcgg 3176581 atgatttccc gatgcccgcg attatctgtg gcgatcgccg gttgttctgc cgccattccc 3176641 tcaagcacat tcataccgag gccttctcta atgctggatg cgacagatac atccgcaagc 3176701 tgaatcaact catgtatgtc gctgcaaaag ccgtaaaaac agacatgggc ggaggcacca 3176761 agcttttcag ctaacgtttg atacgtatgt tccattgccc cttccccggc aaacacaagg 3176821 cggagtgagg gaattttttc ttttagcaag gctgcggctt caattaactg cttctggttt 3176881 ttgttcagat tgagctcagc cggataaacc aatataaaat catcttcacg gaacccgtgc 3176941 ttttctctga gtctttgctg ctctatcgga ctgacaggcc ggaaacgctc ggtattgacg 3177001 ccaatgccgt gaattttctg cgtccttccg cccggccttt gaagtccttt cgcccgtatg 3177061 taatcctctt cattaatcgt aatcaggcag tctgtatatg ctgaaagcca tttctcaacc 3177121 ggatagtaaa gaagccaatt tttcatcggt gcccctttgc agaagtgaaa tccgtgcgct 3177181 gtgtacagca cctttgttcc gtgccgccgt gcctgcctcg ccgccagtct ggcgagaacg 3177241 ccgccgaccg gtgtatggca atggacaatg tcgtattcat aagtgtcaat cactttcttc 3177301 agctgcctat aaacggccag gttctgaggg tcaaaaggtg acctgcgaat cgggatggag 3177361 aatttctcat ccacatacgg cagcttggtt tgtccgttcg cggcgacatg aacctcccag 3177421 cccatttgct tgaaccattt aaaataaggg aggtgaaagg ccttaaaatg ataatcaaca 3177481 gtcgcgcaaa acaatatctt tttcgtcatt ttcactcccc ctaatgaacg ctggcagccg 3177541 tcatttcttc tgatgtattg attgccgcaa acagcctcgc tctcaggtcg gcttccggca 3177601 gctcatgaaa atcctcgata aagcgcatca gcaccggcca atcgccgtcc accgctttac 3177661 cgatgtgaat ttttggaaag atttgttcag catggacttc atttttgttc agcaattctt 3177721 catacatttt ttcgcccgga cgaatgcctg tgaattcgat tggaacctgc tcagtcgtgt 3177781 agccggacaa atgaatgagg tttttggcaa gatccacaat ctttacgggc tctcccatat 3177841 cgagaacgaa aatttgacgc cctttcgcca gtgccccagc ctgaatcaca agccttgatg 3177901 cctcgggaat cgtcatgaaa tagcgggtca ttgccggatg tgttactgtc accgggccgc 3177961 ctttttcaat ctgttttttg aaaattggaa tgacgctgcc gcggctcccg agtacattgc 3178021 cgaagcgaac agcaacaaat ttggttctgc tgactttccc aagattcata ataatcatct 3178081 ctgcgaatcg ttttgtcgcc cccattacgt tggctgggtt caccgctttg tccgatgaaa 3178141 tcagcacgaa tgtctcagtt cccgacatat cggctgcttc cgcgacattt tttgttccga 3178201 taatattgtt tttgaccgcc tcttctggat tgtgttccat taaaggcaca tgcttatggg 3178261 cagctgcatg atagacaaca tgcggctcgt attttttcat caaggtaaac attttatcgc 3178321 ggtcctgcac atcagcgatt tccgtatgga acacaatgtg tttgccgaat cgtccgttca 3178381 gctctgtata aatcgaatga atgctgtttt ccccatggcc gagcagaatg atttccttag 3178441 gctgaaacgc gctgatctga cggcagattt ccgagccgat tgatccgccc gctcccgtga 3178501 cgagaactgt ttttcctttg atgcggttcg aaatttcgct agtgtcgagg gttaccggct 3178561 ttctgccgag caagtcctca gcttttacat ctctgatttg tccggcagtt cgtgtgccaa 3178621 gcagcatttc atcaaaatga ggcataattt taatgcttac tccggttcgc acacattctt 3178681 tatataacac ctgaagctca tgggtgcgga gtgaaggaat ggcaataata atataattaa 3178741 ttttgagctt ttgcaccgca ggcatgatac tttcttttcc gccgattacg ggcagcccca 3178801 taatttctaa tttatgcttc gtttggtcgt catcaataaa agcgacaggt atgatatcag 3178861 gttcatcttt cgaaagcagc tgcctgacca tcagagtccc acctgagccc gccccgataa 3178921 tcagcgcgcg ggacgaggcg cagcgttttt tcctgatgct ttcgtttaat actctggata 3178981 aaatacgggt ccctccaata gacaaaagct gaagcaccca gcacgcggtt aacagacgga 3179041 agaacatcgt gtgatacaca gcatactgaa tgacgccggt cacagcggct gaaagcgtaa 3179101 tgcccttaag caggacaatc agctcgccaa gcccggtgta tgtccacacc tgtttatact 3179161 gattgaacag gaaagcacac acatgatagc tgaggagcaa gctgacagcg gtaagcagta 3179221 atgctccgga gtcataaaat tgataggaat cttttaaaaa ttgatatcct gcaataactg 3179281 aatttaaaac gaggtaagta tccagcgcaa taatcattga cagtcttctc cggtaactca 3179341 accttttccc ccctaattct tttatcggtt tagctgcggc ggttttcgtc tctccaaaaa 3179401 atcggcagca gctaaaccga caatacgtcc tatgtatata tgagataagt gggcatttaa 3179461 cccatcctca cgccccgcca gcgacgacca gcatctaagg cagcaacttc agctgcccac 3179521 agcagagccg agtgcctcca ttgatacagg tcaggagaca tcacctttac aaaaactagt 3179581 aggaatagtg ttccgatttt ttcattttct ttttgtttaa aagagcgcct aacagcttcg 3179641 cattggattg ttccagtgca tcttttgctt tcagaacggt atcggttttt gtttttccgc 3179701 ttaaaacgac gagcacgctg ccgtctgtct gatttgctag aatctgagca tctgcaacag 3179761 ccaaaagagg aggggaatca aagatgacga ggctgaattg ttcatagatc tcagatatta 3179821 aatctcccat tgcttttgaa gacaacagtt ctgccgggtt tggcggggtc ggcccgcttg 3179881 tcagtacata taagttatcg atcggcgtct tttgcaccgt ctcactgagt gaagcattgc 3179941 cgaccagcac atttgtcagc ccggttacat tatcaacctg aaacgtctga ttgatggtcg 3180001 gctttcttaa atcggcatcc accagcagta ctttcttttc ctgctgctgc gcaaagacag 3180061 ccgcaagatt cgctgcactg aacgatttac cttcaccagg cacagaggag gtgacgagga 3180121 tagatcgcaa gttggtctgg acagatgaga actcaatgtt tgtccgaatg gtgcgatatt 3180181 gttccgcaac aactgattta ttgtgtaaaa cagatatttg agccaaacct cgccttgctt 3180241 tcttttttct aaagatcact cgcttcactc cccgaaatgt tttatcccgc gattccgccc 3180301 tttgtggaca tcaggaacgg agcctaagca tggcaatccg gttctctcgc tgagctgccg 3180361 tgcgcttttg catgtatcat cgagaaaatg cagaaaaaat gccagtgtaa tgccgcccat 3180421 gacagcagcg ccaaaagcca tgaccatatt tcgcagcctg gccggcttga tcatcgggct 3180481 ttccgaagcc ttcgcctctg ataatatatg tacgccttgt acattcattc tttcatctac 3180541 ttctttttca aacttgttca ctaacgtgtt cgcaatctca gctgctttcg ccggatcgtg 3180601 atcctgaacg gcaacgttga ttatttctga ttcattttca ctgctggtaa ccacttttcc 3180661 tttcagcgag gaagccgatt cagataggtg caattccgcc ttaacttctt ccatcaaggc 3180721 agtgcttttc ataatcgatt ggaacgtgct gctatactga agatttcgct ggatgtcact 3180781 gagattcgag ttttcttcac cgtctgattc atgaaccagc acctgtgtcg acgcctggta 3180841 ggtcggtgaa atgaccttaa attgcacaaa acccataata agggtgacgc cgattgtgat 3180901 gagcagaatc agcacgaatc tgtgtctgac aatcgcatat aattctttga aactcatatt 3180961 ctcattcatg tattcatagc cttcagcctt cccgcggctg gcttcccgcg cccctttctg 3181021 ttaatgattg gattataaaa gaaaacgtta ttatttaaaa attgcaaaat aagccaataa 3181081 gttctcttta gagaacaaaa tcatgatttt cctctaattt actgcacttc ccttattatt 3181141 ttaaatttta taaagaacga aaaattcctt ataatgaacg aaataacgac aggaatagag 3181201 gagaatttca tattatgatt ggaagaatta tccgtttgta ccgtaaaaga aaaggctatt 3181261 ctattaatca gctggctgtt gagtcaggcg tatccaaatc ctatttaagc aagattgaaa 3181321 gaggcgttca cacgaatccg tccgttcaat ttttaaaaaa agtttctgcc acactggaag 3181381 ttgaattaac agaattattt gacgcagaaa caatgatgta tgaaaaaatc agcggcggtg 3181441 aagaagaatg gcgcgtacat ttagtgcaag ccgtacaagc cgggatggaa aaggaagaat 3181501 tgttcacttt tacgaacaga ctcaagaaag aacagcctga aactgcctct taccgcaacc 3181561 gcaaactgac ggaatccaat atagaagaat ggaaagcgct gatggcggag gcaagagaaa 3181621 tcggcttgtc tgtccatgaa gtcaaatcct ttttaaaaac aaagggaaga tgatgatcgg 3181681 ttaaagggct aacgttcgca tctatagggg aaatctgttt ataatggggg aaaaagggag 3181741 agaacacaat gactcatcaa atagtaacga ctcaatacgg caaagtaaaa ggcacaacgg 3181801 aaaacggcgt acataagtgg aaaggcatcc cctatgccaa gccgcctgtc ggacaatggc 3181861 gttttaaagc acctgagccg cctgaagtgt gggaagatgt gcttgatgcc acagcgtacg 3181921 gctctatttg cccgcagccg tctgatttgc tgtcactttc gtatactgag ctgccccgcc 3181981 agtccgagga ttgcttgtat gtcaatgtat ttgcgcctga caccccaagt aaaaatcttc 3182041 ctgtcatggt gtggattcac ggaggcgctt tttatctagg agcgggcagt gagccattgt 3182101 atgacggatc aaaacttgcg gcacagggag aagtcattgt cgttacattg aactatcggc 3182161 tggggccgtt tggctttttg cacttgtctt catttaatga ggcgtattct gataaccttg 3182221 ggcttttaga ccaagccgcc gcgctgaaat gggtgcgaga gaatatttca gcgtttggcg 3182281 gtgatcccga taacgtaaca gtatttggag aatccgccgg cgggatgagc attgccgcgc 3182341 tgcttgctat gcctgcggca aaaggcctgt tccagaaagc aatcatggaa agcggcgctt 3182401 ctcgaacgat gacgaaagaa caagcggcga gcacctcggc agccttttta caggtccttg 3182461 ggattaacga gggccaactg gataaattgc atacggtttc tgcggaagat ttgctaaaag 3182521 cggctgatca gcttcggatt gcagaaaaag aaaatatctt tcagctgttc ttccagcccg 3182581 cccttgatcc gaaaacgctg cctgaagaac cagaaaaagc gatcgcagaa ggggctgctt 3182641 ccggtattcc gctattaatt ggaacaaccc gtgatgaagg atatttattt ttcaccccgg 3182701 attcagacgt tcattctcag gaaacgcttg atgcagcgct cgagtattta ctagggaagc 3182761 cgctggcaga gaaagttgcc gatttgtatc cgcgttctct ggaaagccaa attcatatga 3182821 tgactgattt attattttgg cgccctgccg tcgcctatgc atccgcacag tctcattacg 3182881 cccctgtctg gatgtacagg ttcgattggc acccgaagaa gccgccgtac aataaagcgt 3182941 ttcacgcatt agagcttcct tttgtctttg gaaatctgga cggattggaa cgaatggcaa 3183001 aagcggagat tacggatgag gtgaaacagc tttctcacac gatacaatca gcgtggatca 3183061 cgttcgccaa aacaggaaac ccaagcaccg aagctgtgaa ttggcctgcg tatcatgaag 3183121 aaacgagaga gacgctgatt ttagactcag agattacgat cgaaaacgat cccgaatctg 3183181 aaaaaaggca gaagctattc ccttcaaaag gagaataaat atggggaaaa caggatacat 3183241 tggtgctgcc attgttgtgg cagcttgtat cattattttg tcggccgtgg tatgtttacg 3183301 ggacacagtc tattaccagc ctatgcgctg gactggcatc atactgtttt tcgcgggaat 3183361 tgtgatggtt cccgcatact cagcaaaaag aaaacccgga aaagagaagt aattctcttt 3183421 tccgggtttt tatgtttatt ataatcttcc cgcgcgaata tcgtctgtca ttccctcata 3183481 aggagccttc gaaatcactt cttcgttgtc gactccttca tttttcagaa atgtaatttc 3183541 cgcaaattca ggtacaacgt attttggata cgtttcatat ttttcgcggg attctttcat 3183601 caaatcaatg tggtcatttt ggtagcaaac cgtaatttca ggatgttcat gcacccattt 3183661 cgggaagaaa ataatgccat gcatgcgttt ttcatttggc ataaagttta atgaaacatc 3183721 cgtgccagtc ggctctgtcc aagacacttt atatacgcct tctgtcagtt tgacaatatt 3183781 cacttcctga tctcgaaccc agcgtccggc aaccattccg ctatgaattc tataatcaat 3183841 tgtatggtcg tttttaatat aaatctcgta ttcccatccg ttttcatacg tataaatcat 3183901 gtggcttccg ataaagtttt ccatcttaca cactctcctt agtcttttac tgtacttcat 3183961 aaatgtctag tagaacgtaa tcaggggttc tttctgcgga accgataaac aagcggtcat 3184021 ggagccattg atagacttca ctgcctgttt caaacgtcgg taccgtacga aaataaacat 3184081 gctccggttc aataatttcc ccggctgccg cttgttttcg aaacggcttg ctgacttgcc 3184141 gtattccatt gttttcaatg taaatcagtt catgatctgc tgtttcaatc acatacctgg 3184201 cagataaatc tgttctgccg ttagcgcgaa tcatttgtga atcggcaccg cccggcaaaa 3184261 tacgtccctt tacttccccg gttattgttc ccgaacgaat cggaatgaat catctcagtc 3184321 ccaggcttgt ctcaccaatc gtgataggcg gatcaacctt gatttctaaa gaggcgaatg 3184381 gttttaaaac cggcttcttc acgagaacca cctcaccttc agaaaaaatc atgtaactat 3184441 ttacatgttc actttaacac cattgcagtt aactgtcaaa caataggaac ataaaaaaac 3184501 aaggactgtt tgaagacagt ccttgtctga agctagcttt gataagcaag atatgtgctg 3184561 acagtgcttt tggcaagaca ggcagaggaa tctataatcg gaatctcact ttgaatatga 3184621 tctaacaccg catttaaatc cgtgcaggct gaaatgatga tgtctgcatg ctgactgatt 3184681 tcttcatata gcgtctgcca caatgcttgt gtatgctgca tatgatttgg ctgtttgatt 3184741 gcggcgataa gctggttcac agcctgctgc caatggtcct tgtgaataac ttcttgtcca 3184801 tttcccttca gaactttttg gtagatggcg gattggatgg ttggctctgt tcctaaaacc 3184861 accgcttttt ttgcgggatg cggaatctct tttatcgttt cctcaacaat atgcaacata 3184921 ggaactgaca atgcctgctg aatctcttca tagtagacat gcgccgtatt acaaggcagc 3184981 gcaatgaaat ccacgcctgt tttctcgagc tttaccgctc cgtcgataat cgcttttttc 3185041 atctcgtcat ggtcaattgg acgatctgca tagaagggcg tcgggcatga atagatcatc 3185101 atgtgcggat agtcaatatc gtttgaagcc ccatacagct tctgacagta atcaatcacc 3185161 ttatcaataa acggcgaggt cgatttcggc cccattccgg ctaatattcc gatcatcaaa 3185221 ttcattcctt tctacttcgt acggaccgct tcttcctctg agccatcctc atagaggata 3185281 aagcttttcg cagcatcctc acctaatgta aactcgactt caacagacaa tgctcgcaga 3185341 aagaaacggg tttccgagga aggaaataac tccagtctca gctgtccggc gatctccaaa 3185401 taaagccgtt cattctcggt tgtcacctgt gcagccgtcc catcctgcaa caggtagctg 3185461 ccaacatagc ggctgtatat cgccgtatca attgcttttt tctttttatc agcaggacgt 3185521 tccgggacat catatggctg gccaaataga atatgttccg ccgccttcag aatcgcttgt 3185581 tcatattcag tatcctcttc cttattactc aaatagatca gcgttttacg atgatcgata 3185641 tatcggatca tcatcgtcga atagccgggc catcctccgc tgtggctgac aatccgccct 3185701 ttttcaggac tgttttgcag cacccagcca aagccataat caattgtttc tccattgttg 3185761 aggcgcactg gagaaaacgc agattcctta gaagccttgc tgatgaaatc gtcctgatat 3185821 aaagcctgat caaatcgaaa caaatcgctt gtgacagagt taaccgtccc atctccctgt 3185881 atgccatcga gatacacaac atagttcgtt tcctccagct catcagggag gacgtatgtt 3185941 tcggaatgta catcatacac atatccatat gcataatgat caattcgctc aggcgaaagc 3186001 ctcctgttat acactcttgt ttcattcatg cctgccggta aaaaaatact tgtttttata 3186061 aaatccgcat agctcatgcc agatgctttt tcaatgataa ccgccagcag cacatacccc 3186121 gtattgctgt acatccagcc ttcattcggt tcaaaataac cagatagccc ctcattcatc 3186181 agcatatcga caatatcctg attcaccgca atcttgtgtg aatcccaatt ggcaaaaaac 3186241 catcccatat aatcaggaag ccctgacgta tggttcaata aatgccgaat cgttacgccc 3186301 tgatacggaa aaccgggcag ccagcgatcc actttatcct catagccaag aatccccttc 3186361 tcctccagca agatgattcc caatgctgta aaaggctttg acaaagacgc taactcaaac 3186421 aaagagttgg ttttcaacgg gcgtttttcc gtcatttccg catagccaaa agagtggtga 3186481 tataaaatat cgccaccctc cgcagccaga accgtcccgt taaactgatg tttttcgcct 3186541 aatgtctcaa ataacgtctg aagatgcttt cttttattct gcttcattcc tccacctccc 3186601 atatctctgt acgttactaa cctactaacg tttcaaatat tttgaaaaat ccttcagtta 3186661 gagatccttt ttaacccatc acatatacct gccgttcact attatttagt gaaatgagat 3186721 attatgatat tttctgaatt gtgattaaaa aggcaacttt atgcccatgc aacagaaact 3186781 ataaaaaata cagagaatga aaagaaacag atagattttt tagttcttta ggcccgtagt 3186841 ctgcaaatcc ttttatgatt ttctatcaaa caaaagagga aaatagacca gttgcaatcc 3186901 aaacgagagt ctaatagaat gaggtcgaaa agtaaatcgc gcgggtttgt tactgataaa 3186961 gcaggcaaga cctaaaatgt gtaaagggca aagtgtatac tttggcgtca ccccttacat 3187021 attttaggtc tttttttatt gtgcgtaact aacttgccat cttcaaacag gagggctgga 3187081 agaagcagac cgctaacaca gtacataaaa aaggagacat gaacgatgaa catcaaaaag 3187141 tttgcaaaac aagcaacagt attaaccttt actaccgcac tgctggcagg aggcgcaact 3187201 caagcgtttg cgaaagaaac gaaccaaaag ccatataagg aaacatacgg catttcccat 3187261 attacacgcc atgatatgct gcaaatccct gaacagcaaa aaaatgaaaa atatcaagtt 3187321 cctgaattcg attcgtccac aattaaaaat atctcttctg caaaaggcct ggacgtttgg 3187381 gacagctggc cattacaaaa cgctgacggc actgtcgcaa actatcacgg ctaccacatc 3187441 gtctttgcat tagccggaga tcctaaaaat gcggatgaca catcgattta catgttctat 3187501 caaaaagtcg gcgaaacttc tattgacagc tggaaaaacg ctggccgcgt ctttaaagac 3187561 agcgacaaat tcgatgcaaa tgattctatc ctaaaagacc aaacacaaga atggtcaggt 3187621 tcagccacat ttacatctga cggaaaaatc cgtttattct acactgattt ctccggtaaa 3187681 cattacggca aacaaacact gacaactgca caagttaacg tatcagcatc agacagctct 3187741 ttgaacatca acggtgtaga ggattataaa tcaatctttg acggtgacgg aaaaacgtat 3187801 caaaatgtac agcagttcat cgatgaaggc aactacagct caggcgacaa ccatacgctg 3187861 agagatcctc actacgtaga agataaaggc cacaaatact tagtatttga agcaaacact 3187921 ggaactgaag atggctacca aggcgaagaa tctttattta acaaagcata ctatggcaaa 3187981 agcacatcat tcttccgtca agaaagtcaa aaacttctgc aaagcgataa aaaacgcacg 3188041 gctgagttag caaacggcgc tctcggtatg attgagctaa acgatgatta cacactgaaa 3188101 aaagtgatga aaccgctgat tgcatctaac acagtaacag atgaaattga acgcgcgaac 3188161 gtctttaaaa tgaacggcaa atggtacctg ttcactgact cccgcggatc aaaaatgacg 3188221 attgacggca ttacgtctaa cgatatttac atgcttggtt atgtttctaa ttctttaact 3188281 ggcccataca agccgctgaa caaaactggc cttgtgttaa aaatggatct tgatcctaac 3188341 gatgtaacct ttacttactc acacttcgct gtacctcaag cgaaaggaaa caatgtcgtg 3188401 attacaagct atatgacaaa cagaggattc tacgcagaca aacaatcaac gtttgcgcca 3188461 agcttcctgc tgaacatcaa aggcaagaaa acatctgttg tcaaagacag catccttgaa 3188521 caaggacaat taacagttaa caaataaaaa cgcaaaagaa aatgccgata tcctattggc 3188581 attttctttt atttcttatc aacataaagg tgaatcccat atgaactata taaaagcagg 3188641 caaatggcta accgtattcc taaccttttt aggaatattg ctgtttatcg acttatttcc 3188701 aaaagaagaa catgaccaaa aaacaaaatc aaaacagaag ccggactacc gggcggcata 3188761 tcattttacg acgccggata aatggaaaaa tgaccctcaa aaaccgatct attttgatgg 3188821 caagtatcat tatttctatc tatataaccg ggattaccca aaaggcaacg gcacagaatg 3188881 gcgccatgcc gtctcagagg atttggtgca ctggaccgat gaaggcgtgg cgattccgaa 3188941 atatacaaac ccggacggtg atatttggac cggttccgtc gtggtggata aagagaacac 3189001 agccggcttc gggaaaaatg cgcttgtcgc gattgtgaca cagccctcag ccaaagacaa 3189061 aaaacaggaa caatatttgt ggtacagcac agataaggga aaatcattca aattctacag 3189121 tggcaacccc gttatgccta atccgggcac agacgatttc agagatccga aagtcatatg 3189181 ggatgaccaa gataacaaat gggtcatggt catggctgaa ggatcaaaaa tcggctttta 3189241 tgaatccgat aatcttaagg actggcatta cacaagcgga ttcttcccag aacaggcggg 3189301 aatggtggaa tgtcccgacc tctacatgat gcgggcaagc gacggaacga ataagtgggt 3189361 tctcggtgcc agcgcgaatg gcaaaccgtg gggcaaacca aatacgtacg cctactggac 3189421 cggaagcttc gacggaaaag aattcaaagc ggatcagact gaagcccaat ggcttgacta 3189481 tggcttcgac tggtatggcg gtgtgacgtt cgaagacagc aaaagcacag atccattaga 3189541 aaagcggtat gcgcttgcct ggatgaacaa ttgggattat gccaacaaca ccccgacaat 3189601 gaagaacggc tttaacggca cagattctgt catacgcgaa ctccggctga aggagcagga 3189661 tggaacatac agcctcgtct cacagccgat tgaagctttg gagcagctga ctgtttcaac 3189721 tgacgaaata gaggatcagg atgtgaacgg atcaaaaaca ttgtcgataa caggtgatac 3189781 gtaccagctt gatacggatc tttcttggtc agagctaaag aatgcaggcg tcaggctcag 3189841 agaatcagaa gaccaaaaac gccatattga tgtcggcatt ttcgctgaag gcggctatgc 3189901 ttatgtcaat agagcagcca caaatcagcc tgacaaaagc aatacctatg tcgaaagcaa 3189961 agctccttat gatgtaaaca aacgtaaggt gcatttgaaa atacttgtcg ataaaacaac 3190021 gatagaagta tttgttggcg acgggaaaac cgttttttca aatgaagtct tcccaaagcc 3190081 tgaagataaa ggaattaccc tttattctga cggcggcaca gcctccttca aaaatataac 3190141 agtgaaacac tttgattcga ttcatgaata aaaacagggg cggcgcaggc tgcccctgtt 3190201 tttttattag gagcggtatt ctctgttaca tattgggcat tgtaaggaat ataaggctgg 3190261 tttcaaagga ggaagcgaat gtctaaacaa ggaaattttc aaaaatcaat gtcgctgttt 3190321 gatctgattt tgattgggat gggagccatc tttggatcag cgtggctgtt cgctgtcagt 3190381 aatgtcgctt caaaagcagg gccctccggc gctttttcct ggatcctcgg aggagccatt 3190441 attttgttaa tcgggcttgt atatgcggag ctcggagccg ctctgccccg taccggaggc 3190501 atcattcgat accccgttta ttcacatggc caccttgtcg gctacttaat ttcgtttgtc 3190561 acgattgtcg cttatacaag cttgatttca attgaagtga cagctgtgcg ccagtatgtg 3190621 gcctattggt ttcccggcct gaccattaaa gggtctgatt cgcctaccat ttccggctgg 3190681 atcttgcagt ttgccctatt atgcttgttt ttcctgctga attattggag cgtcaaaacc 3190741 ttcgctaagg cgaatttcat catatcgatt tttaaatata ttgtgccgat taccatcatt 3190801 attgtgctga tctttcattt tcagccggag aatttatccg ttcaaggatt tgcaccgttt 3190861 ggatttacag gtattcaggc tgccatctcg acaggcggcg tcatgtttgc gtatctcggc 3190921 ctgcatccga ttgtatctgt agcaggtgaa gtccaaaatc caaaacgcaa tatcccgatc 3190981 gctttaatca tttgcatcat cgtttcaacc atcatttata ctgttttgca ggtcaccttt 3191041 attggtgcaa tcccgacaga aacactgaaa catggctggc cggcaattgg ccgggagttc 3191101 tcattgccgt ttaaggatat tgcggtcatg ctcgggttag gctggcttgc aacgcttgtc 3191161 attttagacg ccattctgtc tcccggagga aacgggaata tctttatgaa tacgacatcc 3191221 cgccttgttt acgcctgggc gcgtaacggc acattatttg gcatattctc aaaggtcaat 3191281 aaagatacgg ggacaccccg cgcttcgctt tggctttcgt ttgccctgtc cattttctgg 3191341 acacttccct ttccttcgtg gaacgcgctc gtcaatgtct gttcagtcgc gctcattctt 3191401 tcatatgcga ttgcacccat ttcttcagct gcgctgaggg tcaacgcgaa ggacttaaac 3191461 aggccgtttt atttaaaggg aatgagcatt atcgggccgc tttcctttat atttacagcg 3191521 tttatcgtgt actggtcagg atggaaaaca gtctcctggc tgctcggttc acaactcgtg 3191581 atgtttttga tctatctctg tttcagcaaa tatacgccta aagaagatgt cagccttgct 3191641 cagcagctga aatcagcctg gtggcttatc gggttttata ttatgatgct gatcttttcc 3191701 tacatcggtt ctttcggaca tggtttaggg attatcagca atcccgtcga cctcatttta 3191761 gtcgcgatcg gctcacttgc gatttattac tgggcaaagt ataccgggct cccaaaagcc 3191821 gccattgatt atgataaata aagaagcaag aggttttctt gcttctttat tctttacaaa 3191881 caaacataca cgcgataaaa tgaatgagag tcagtcatta ctggaggtgt tcctcatgcc 3191941 aaaacaaaca tcgggtaaat acgaaaaaat attgcaggcg gccatagaag tcatttctga 3192001 aaaaggcctc gacaaagctt ctatttctga tattgtcaaa aaggccggca ctgcccaagg 3192061 aacattctat ttgtattttt catctaaaaa tgccctcata ccggccattg cagaaaatct 3192121 cctcacccat acacttgatc aaatcaaagg taggctccat ggggacgagg atttttggac 3192181 cgttttagat atattaattg atgagacatt tctcattaca gaacgccata aggatattat 3192241 tgtcctctgt tattccgggc ttgcgatcga ccactccatg gaaaaatggg agacgatcta 3192301 tcagccttat tattcctggc ttgaaaaaat catcaacaag gccattgcaa accatgaggt 3192361 aacggaagga atcaattcaa aatggacggc cagaacgatt atcaacttgg tcgagaatac 3192421 tgcggaacga ttctatatcg gatttgaaca agatgaaaat gttgaagtgt ataaaaagga 3192481 aattttcact ttcttaaaac ggagcttagg tactgcttaa aaaatgactg ggtaacaccg 3192541 ctcatttttt aatgccctaa aaatgactga cgttcattca taaaatagag aggtgtttca 3192601 tttgaattgg gttcttgttt ttattgcagg gcttttagag gttgtttggg cctcttccct 3192661 caaacatgcc gattcgcttt tggattggat catcattttt atcttaatcg cggtcagctt 3192721 tatcctgttg atccgctctt atcaaaaaat cccgatggcc gcggcgtaca ctgtgtttgt 3192781 gggaatcgga accgtcggaa catatctgac tggaattgtt ctgggcgaat ccttctcagc 3192841 agcccaaatg ttctttttag ctttattgct ggctggcatt ttaggaatga aattatttac 3192901 gaaagaaagc aaatctcagc cgggaggtga aaaataatgg catggttttt attagtgatt 3192961 gccggcatag aagaaattat agctgccatt gccatgaaat atatagacgg aacaagaaaa 3193021 aaatggccga tcattgtgat gactgttgga ttcggcttat ccttttactg cctgtcccaa 3193081 gcgatgatcg tcctgcctgc cggagtcgca tatgccgtct ggactggcat tggaagcatt 3193141 ggtgtttcgg cggtcgggct catctggttt aaggagcggt ttcagctttc acaggtgatt 3193201 tcactttgcc ttatcctagc cggcgtcatc ggcctgcgtc ttacgtcatc ttcataaaat 3193261 caaggcatat acagctgtat atgcctttgc cattaagctt cgtgatgttt ttgaagatga 3193321 agcggcggcg ggatgagcca gcctttgttt tttagcagcc ttaagtattt tgcgccggtt 3193381 gccgctttcg acatatgaaa ttgcccaaac atcatggcaa tatcctcacg aatcgattgc 3193441 cccatcattt tgctgcatgt cacaagacct gcagcatttt ctgctgccgc ggaagccgcc 3193501 acatccggat cgagaaaccg tgcaccaggc ggaatatcgt taagatctgc tgtcggcggt 3193561 tcaggagaag ccggcggcag cgccaccccg ttttctttca ggatcgtgct gacctgtttg 3193621 atttcatctt ggcatttctc aatagactca cgaagcagct tcttcaggtc gtcatcaccg 3193681 acatgattca atagcatttg gtaattgccg accattttat tgcccgccat cacataactc 3193741 cacaagccga atacctcacc gtaatgcatc ggttcatcct gcggatttcc gcttaaaata 3193801 cccatgctca ttctcctccc atattcaata ttgcacattt cataacgtgc ccaagcggag 3193861 gaacatttat gtttcagcgg aaaagattta tgaaatgaaa caaaacaaaa aagacaagag 3193921 tggcaagttg ccaaaccatt gtctttcctg ttgtttgatt ggacgcactg aagggattcg 3193981 caccccgaca gacaagatac cggaaaccat tcaagtgctt tttagtatga gtcattgatt 3194041 ctgtctttaa taaactttaa cgagatggcg ggatgctttg cggaaaacga aatacatttt 3194101 cggggtcata tttcgccttt atttctcgaa gccgcgcaaa gtttgcgcca taatattctt 3194161 ttccgaagtt ttcaatgttt tgatctggaa cattaacata tgaacctgct acatatggtt 3194221 gcatcagctg acgcactctt tcaactgatg caagatttga atcttcttgt gatttatttt 3194281 tccaactagc cgtccattcc gtataaaata atggatggcg ccaaaaaaag gcagtttcgt 3194341 ctttagggac tctgcttata gcaccacccc aattgataaa aaagaaattg gcttctgttc 3194401 cagtagcatc ttccaaaaat tttctcatga ttgaaatggg ttcgtcagac caaaaatcat 3194461 gaccccatgc cgaggagaat ttaacactct gatcatttct gccagggatg ggttcgtcag 3194521 ggtctaagaa atctatagca tctggatagt ataatgtttt gatatctgct tctgttggag 3194581 ttcccgcatg taataaaggt tttaataatc gaatcaattc agttttcgaa ccgaggaaaa 3194641 ttccttctgc atgacacaaa ccatttattt tgctgtaaat ttcaaggtag catcctaatc 3194701 gttcatctac aaacggagcc catttctgcc aagctttaaa taccgtttct aattgttccc 3194761 acggccagat aatattgaag acggttgcag ttttaggggc acgatgaact ttgaatgtat 3194821 attgggtatt atatccaaag ttacctcctc ctccgcctct agaagcccat agcaaatcct 3194881 cattgtgaga ttgatctgcg tgaataatcc ttccttttgc atctaccgtt ttcagcgcga 3194941 gaaggttatc acttataagg ccaatcgatc gtgagagtac accaaatccg ccgcccatcg 3195001 taattccccc gattccaact gttgggctat ctccaaacgg agccataaaa ccgtctcgag 3195061 ctaatccctt tacaagcggg ccaacgggaa taccagtttg aacggttgca atagcgtttt 3195121 cttcatctaa gaaaacttta ttcatgtcac tcacatcaat aacaattcct ccacttacta 3195181 ctgaaaggtt cttatctaaa gcatggcgac cgcttctgac acgtaagggc actttattct 3195241 cacgagccca tttaatggca ttacttacat cgtatgaatt ttgcgcaaaa acaaagacaa 3195301 gaggatagac atccacataa gggttccaat tcttaatagc ctctgtatag ccggggtctc 3195361 ctttgaagat tacacgccct gtcaactgtg ttgatcccat atattatttc actcccaaag 3195421 aaattcgatt cagatactaa aatatgcagg agctggataa tcgcatagac aaatgatcta 3195481 cgaactataa atataatacg ctaaggcctt tttcgtcggt gaggtctgct gagaaacatt 3195541 tttcaaacaa ttttgagcaa acttcctgtc caatcctcca acaagcgttt tttcttatcg 3195601 tttttaggag cagtgtccag tttttttcgg agtgaatatt cgtttaggcc aaaagaaaag 3195661 agagatgaag aagtgtttag taccagaggt atacatccat acaacagact ctagatcatc 3195721 atatactgaa tgtatgtaga aaggagacat cagctttggc aaaatatcgg attatgacct 3195781 ttgacggcgg cggtacctta ggtgctttaa gtttacaact attaaacaga ttggctaggc 3195841 aaaacccgaa gttaattagt cgaacccatg tattttcggg aaattcaatc ggttcattta 3195901 ctgcccttgc attagcaagc ggaagatctc cgagggaaac acttcagtat tttgaggatg 3195961 aaatcctacc cgcattcagc atttcccggc caggcggacc tgttttcaac caacaattac 3196021 cctattccgg ttttattaaa gcggtaagaa attttttccc agcagatctt caacttatag 3196081 atttaagaaa acgaattgtt gtcccatcat tcaaattata ctctcaaaaa ctggaccgtt 3196141 ggactcctgt cttatttcac aattttcccg gctctcccta tttaaatgaa aaagtgagtg 3196201 atgtcatact gcggagcagc ggtgctcccg cgacgcaacg cgcctatcaa aactatgtgg 3196261 acggatatgt agtagcaacg aatcccagta cagccagtat cgcgtttgca gttggtaaag 3196321 ccaacgtgcc attggatcaa attgcggtat tgtccatcgg aacaggtgaa gccccgactc 3196381 ggttaagaag agatacgagg ggatggggaa tggtaagtgc agataacata cgtcccgaaa 3196441 atctgaagaa ccttcctcca aattggggag tccttttgga caggtcgcct aatgaacctt 3196501 tactgccatt tcttcagatg attgctggcg gtaatgggta ctatgaatcc atggtcagtg 3196561 cgaatcttct gggagatcgt tttttccggt tagatccgcg gattccgaac ttctccaaaa 3196621 cggaccctgc cgtcgttccc gctgtcattg aaattgcgaa caaaacaaac ttacagcctg 3196681 cgaatcaatt tatagagaag aactggggga gcaaataatt atttatttta aatcaattct 3196741 cgcttataca attttgtccg agagaagatt ctcaaaataa atacaggcaa tgggtagaac 3196801 cggatttttt taaaggtttg ttaatcacaa gctaataaga tgaatgaaaa aatcaattca 3196861 tacttcttct tttgaaagtg agggttcaaa ctaaagaatg taattgaaat gttactctaa 3196921 ggtatgcaat tccctttttc acacaaaaaa agacaagagc ggcaaatcgc caaacccttg 3196981 tctttcctgt tgttctattg gacgcgctcg gagggattcg aacccccgac agacgtggta 3197041 ccggaaacca ccgctctatc caactgagct acgagcgcat atagactgcg ttatgagaac 3197101 gtcagcacaa ctaattatac gataattcct ttcaaataac aaccctctat ttcgagaggc 3197161 cgttttttaa atagacaaag catcttaatt ggcaatctga catacgatgg tttgaacccc 3197221 tgtatttttg gggaaaatgg gaaaaagaga cgactttgca tatcaggcca gctttttgtt 3197281 tgacctttat tgaccaaaaa tgtatcatgt aactacatac ttacctaaaa ggtgaaggag 3197341 gagcattatg aatttaatac ctacagtcat tgaacaaacg aaccgcgggg aaagagcgta 3197401 tgacatttat tctcgtctat taaaggatcg tatcatcatg cttggatctg cgattgatga 3197461 caacgttgcg aactccatcg tgtcacagct tttattctta gcagcagaag accctgaaaa 3197521 agaaatttct ctttacatca acagcccggg cggctctatt acagccggta tggcgatcta 3197581 tgataccatg cagtttatta agccgaaggt atctacaatt tgtatcggta tggctgcgtc 3197641 aatgggcgcg ttcctgcttg cagccggcga aaaaggcaaa cgctatgcgc ttccaaacag 3197701 tgaagtcatg attcaccagc ctcttggcgg tgcgcaaggt caagcgacag aaattgaaat 3197761 tgctgcgaaa cgcattctct tgcttcgcga caaattaaac aaagtcctag ctgaacgtac 3197821 tggccagccg cttgaagtga tcgaacgcga cacagaccgt gataacttca agtctgctga 3197881 agaagcgctt gaatacggcc tgattgacaa aattttgact cacacagaag acaaaaagta 3197941 ataacacaac ctgcaagagc tgcgtctctt gcaggttttt ttcatttcaa ggaattgact 3198001 cccttattct atactgctcc cattcctcat gtaacagctc aagcgtcaaa tcactcgtct 3198061 gcctcacaac cagatcagca ccaagcatcg gctgtccttg accgacacca accgcaaaca 3198121 tccccgcaga tttgattgca gaaatgcctg cttctgcgtc ttctattgcc gcgcaatcag 3198181 caggggaaac atcgagcatc gctgcagctg ttaaaaagat gtcaggatca ggcttcccct 3198241 tcgcaagagt cgtcggatca acaatggcat gaaaatcatc gataattgcc aagcgtctta 3198301 aaatcttagg agcattgcga cttgaagatg ctaacccgat ttttatattt tcgtttttca 3198361 attgacatag aagcctgcca atccccggta aaagatcttc cggcgtcaat ttgctgatca 3198421 gcatttgata atcgcgattt ttccgatgca taagctcttg tttctccgca tttgtatact 3198481 ttgtttccgc cccgccaaag atcaatatgc tttcaagtga ctcttctctg ctgattcctt 3198541 ttagcctttc attcatgtct ctgtcaaaag ggatatcgat ttgttctgcg atgtgcttcc 3198601 aagcgagaaa atgatattca gcagtatctg ttatcactcc gtctaaatca aaaatgaccg 3198661 ctttcatata ctaatgccca tcacagcttc ataaggtttg aggctaatac tctttaagtc 3198721 agcccgctcc tgcggatagt ttgaaattag cactttccaa cgctcatgaa tcagttctgg 3198781 aggcgcttcg aacagagcct tttcttccga taaattcaca acgacaagaa gcttttcccc 3198841 tcgatattct cgaaggtaag aaaagacctg cggatcattc tcctgcaaca gctgataatc 3198901 gccatatatc ataatcttat attgctttcg taattgaatg agcttctgat agtaaaagaa 3198961 aatcgaatct tgatcttcca aagactcttt cacattgata tcttgatagc gggaatttac 3199021 cggtatccac gggtctccgg ctgtgaatcc cgcatgtttt ccggcatccc actgcatcgg 3199081 tgttctcgca tgatcccttc cttttatcat cacggctttg acaaactctt tttctgacat 3199141 cgttttgttt tcgacgacta gttcacgata tgcattcttt atttcaagat catcatacat 3199201 ctccagcggc atatcgctgt tgaccatgcc gatttcttct ccctggtaaa taaacggcgt 3199261 tcctttcatg ccgtgcagaa ccgttgcaaa tgccttcgca cattccttac gcagtttcct 3199321 gtcattgccc cagcgggaaa taaccctcgg ctggtcatgg ttctcaaaat aaagggtatt 3199381 ccagccgaca ttcattaacc cggtctgcca ccttgtcatc gtctttttta aagcaatcaa 3199441 atcaaacggc ttgatctgcc atttcccatt tggcgagttt tgttctttat caatatccat 3199501 atgttcaaat gtaaagatca tattcagctc ttgcctgctt gcatctgtgt actttttcgc 3199561 ctcttcaata tcagagccgt ttgcctctcc gactgtcatg cagtcgtaat gagaaagcac 3199621 ttccctgttc atctcttgaa taaactcatg aagacgtggg ccgttagagt gataacggcc 3199681 gacaatatag ctgcggctgt gatccgtttc gtagtccgga aaatcggtgt atttagaaat 3199741 agagccaatc acatccatcc gccagccgtc aacgcctcta tccatccaga atctcattac 3199801 atcataaact tcccggcgaa cggcttcgtt ttcccaattt aaatcaggct gttttttcga 3199861 aaagtagtgc aaataatact gccctgttcc ttcatcgtat gtccacgctg agcctgaaaa 3199921 gatcgatccc caattattcg gctctgagcc gtccggttta ggatctttcc aaagataata 3199981 atcccggtaa ggattgtcct tcgacttgcg gctttcagca aaccaagcat gctcatctga 3200041 tgtgtggttc acgaccaaat ccatgacgat tttcattccg cgtttatgga cttcatcaat 3200101 cagctgaaac atatcttcat ttgtcccaaa cttttcgtac atgtttttgt aatcgctgat 3200161 atcatatccg ttgtcatcct gcggggaatc aaataccggg gagagccaga tgacatccgc 3200221 cccgaggttt ttgatgtaat ccagcttttg aatcacacct tgcaaatctc cgaatccatc 3200281 tccattggca tcataaaaac tgcgcgggta aatttgataa acgacagctt ctttccacca 3200341 ttcactcatt aggcgttctc ctttcacatc gtccctgtag gacaaccggt tcctcataaa 3200401 cgttcatgtg cagcggctcg ccttttacaa gctcaaaaat aacgcgcttt tcgtcaaccg 3200461 tcacattgat taatcgattt cgataattga tgttgaatga atattcgtcc cattctttcg 3200521 gcaaaaacgg agcaaatgac agcgtctcat tcgcggtgcg catgcctgca aagccatgaa 3200581 cgattgccag ccagctaccc gtcattgaag taatatgcaa gccttcttcc gtatcatgat 3200641 tgtaattatc aagatcaagc cttgctgtgc gcttatataa ttcgagcgct ttcttttcca 3200701 gcttgagttc ggctgcgaga atcgcatgga cagagggcga taggcttgat tcatgaacag 3200761 tcatcggctc ataaaattca aaatttcgcc gtttttcttc cattgtaaaa cggtcattaa 3200821 aaagataaat gccttggaga acatctgcct gcttaataaa attggagcgg agaatcttgt 3200881 cccatgacca attctggtaa agaggccgtt ccgctggatc taattcgtca actgtttgca 3200941 ggtctttgtc caagaacgtg tcatgctgaa cgaaaatttg cagttcttca ctaaatggat 3201001 agtacatgtg ctggatgatt tctctccaga cttccaattc tacttcctgc acatccagat 3201061 ggcggcgttt ctccgctgag atactttcga gactttgtag agtatactcc aacgtccaag 3201121 ccgcaatgac attcgtatac caattgttgt taacgttgtt ttcgtattca ttcggccctg 3201181 tgacgccatg gatcatatac ttattttttc gtttcgagaa gtgaacacgg tcggcccaaa 3201241 atctgctgac tgccacaagt acgtctatcc cgtattcttc catatagtta cggtcgcctg 3201301 tataattgat ataattgtag atcgcataac agatcgcgcc attgcggtga atttcttcaa 3201361 aggtgatttc ccattcgttg tggcattcat cacctgtgaa cgtcaccatc ggataaagtg 3201421 cccccttcat ccccaatttt gcagcgtttc gtttggcagc ctccaactga tgatagcgat 3201481 acaaaagcag gtttttcgtc acctccggct cggctgtcgc caaatacatc ggaacggcgt 3201541 acgcctcagt atcccaatat gcggcacctc catatttctc gccagtaaat cctttcggcc 3201601 cgatattcaa acgggcatcg cccccgtaat atgtcgagaa taactgaaag atattgtagc 3201661 ggattccttg ttgaagctcc tcatctcctt taatctcaat gtccgctttt gcccatcttt 3201721 ccttccatcg atcagtgtgc ctccgttttg catcttcata gccgttctct accacatccg 3201781 ccaaaagctc cttggctttc gataaaagct cttcctcccg aaaatcacgg gaagtcgtga 3201841 caatcacaaa ctttttcaat gatgccttcg tttgataact gtagcgattc tcgacataca 3201901 tttcagtcgt tttaaagctt tcatggacaa aaccctccgt ctcgtttgcc attgcggcta 3201961 ataccgtgaa gcgcggtgtt ccaaatggat tttcgatcgt ttttgccgct aaatggccgc 3202021 tgtgagaatc agcacctttc gcttcctcct gccaaaactg ttcttggtag ttagaatctt 3202081 catttgccac atttccatcc aggtaaggaa caagcgtaat gacagcatct cccgtcaagc 3202141 actccgcttc ataatgaatc gcacagagtt cttttacagc aaggctaaga aaccgctctg 3202201 acctgattct gacggtttta tcttgaatgc ggacaacagc gcttcgccgc agaatcccct 3202261 ctttcatatt gagttctacc tcaaataatt cgattgggtt ttgatggaga tcgatttttt 3202321 caccgtcaac atataggcct atgcccataa agttcatcgc attgatcact tttccgaaat 3202381 attctggata cccgtttttc caccagccta ctcgcgtttt gtcggggaac cacacgcctg 3202441 caatatatgt gccttggtga ctgtcgcctg aatagccttc ttcaaaattc cctctgaccc 3202501 ccatatagcc attggcaaga gacgtcaggc tttccagcag ccgtgtatgc tccttattaa 3202561 atgtatttgt tttgattttc cattcatcaa tctcaaataa ccgctgattt atcatcattt 3202621 cctcccgaat gtaagtttcc attatcacgg cgggttttgg tcaaatatct aaatgcaaaa 3202681 gagatcatca aagtaacgcc acacgaatgg atcatcaata cagtaatcaa atcaaaatga 3202741 accatgccga tagcagctgc cgcaaatgcc ggcagtgctg atgcgcaaat cgctatagag 3202801 gccgcttcct tgaatgatgc aatagagacc atgtttgata tttttgtgat ccagaggcca 3202861 cctgcaagaa caaacgttaa caaaagctgg atcatagaaa ccaccgtata tgccagcatc 3202921 atgatcatcg gcttatactg tgccaaccac aatgtatcga tcaagacctc tacatcatgg 3202981 acgtttggtt tctcgagctt aacgtccatt ttcgcatagc caacagaaaa ccccgtttcg 3203041 ttttgatcgg tgatcaccag ttgatcaggt tgaaatatga tggcgttttc aaatccagtt 3203101 actttcaatc gcccattttc accgcttgtc tcatattcat gcttcatatc gactgccatc 3203161 acattctgcc catcttcaat cctctcagag ctcttcccgc ctgttagttt tccgttcctg 3203221 atttgaaaac cctgcaattg atcagcaaat tgatcattaa ctccttgaat cgctgacggc 3203281 atgaaagatg aaacgctgaa gcgatccatt ttcacaaacg aaaccgctaa cggcgccatt 3203341 aagcaggccg ttaaaaacag aaagagaaaa gagagctgca gccagctgaa ggtattccca 3203401 tagcggcaaa cacctgatgg ggatgcagcc gccttcaggc agcggatgat aaagctttta 3203461 ttctccagat tcttcattgg cattacccct ttgttccgcc ggctgtcaaa ccggacacaa 3203521 agttcttttg gagaaaaaag aatagaacgc atatcggcag tgcggctagt atggcaccgg 3203581 ctgcaaatag agctactttt tgctgctgcg gattagaaat aaaggattgt aatcctacag 3203641 cgatggtcag cctttccggt gagcgaagca gaaatttcgt cagcaaatag tcgccaaacg 3203701 gtgccataaa cgcccaaagc gcttgtaccg cgagcattgg cttaacaagc ggtagaacaa 3203761 ttgaagcgaa aatcctcaga tgtcccgctc cgtcaattcg cgcggcttca tcaatttctc 3203821 tcggcacagt atcaaaataa cctttcatca gccacgtgtt catcggaatt ccgccgccga 3203881 tatagatcgc tgttaaaaac cagtattgat cgagtgcgcc tattagcatc gccaagacat 3203941 aaaaagcagt cagcgccgcc attgtcggca ccatttgaat gattaaaaag aatatcaggc 3204001 tcttttttct gcctgcaaac cgatagcggc tgtacgagta cccggcaagt gtcacaatcg 3204061 taacctgcaa aaccatgacc gatagcgcga tgacaagtgt attgctgtac caattgagat 3204121 aaagcgtttc gtcaaatagc cgcttaaaat gatccaatgt ccaagaaccc gaaaaatcga 3204181 gctgaaaagc cgccgaattc cccacacgga aggctgatga tgccgtaatc agcaacggat 3204241 atataatgac aatacttaaa agcgtcaaaa ataaatacgt acagatttta ttaagcattc 3204301 tggcagtgct cgcgttcacc tacataacct cctcattgcc aaaagcattc gattttttga 3204361 aagcaatcag tgaaattcca atgacaatga aagaaattaa cagtgtcaca gccgccgcaa 3204421 cggaatattg gggtgatgtg cctgttgtca gtttataaat ccacgaaatt aagatatcgg 3204481 tcgatccggc cccggctccc gcactgcctg gccctccctc attaaataaa tagatgatcg 3204541 agaaattatt gaaattaaac gtatactgag taatcatcac gggtgctgtg gcaaataaaa 3204601 tcatcgggaa tgtaatatgc cgaaaacgct gaataaaagt ggccccgtca atctttgccg 3204661 cttcatacaa ttcacctgga atcgcctgaa gcactcccgt taccatgaca tatatatatg 3204721 gaaagccgag ccacgtttga atcataatga gggctgtctt tgtccagaaa ggatcggtct 3204781 tccacgcgat cgcaggcagc tcgacaaacg gcaggtgatt gaataatggt atcacctgtg 3204841 cattcaccgc tcctatgctg tcgttaaaca tgttggaaaa actcatgatt gtaataaacg 3204901 ccggaacagc ccatggaaat aagaaaatca ttcgaaatat ccgcttgcct tttataaaat 3204961 cctgattgac gaaaagtgcc gtcacaatac ctaaaatgat ttgcagcgtt gttgcacaga 3205021 ttgtccagat aaccgtccag cccagtacat tcacaaatgt ttcacgatag gagccaagga 3205081 aaaaaatatt taagaaattt ttaaacccga cccagtcaat cagacgatta ggcggaatat 3205141 gataaaaatc atagtttgtt aatgcaacaa acagagtcac caaaaccgga aaaataatca 3205201 caaacaccat catgatatat gccggcagtg taaatagata cggaaaacct ttatcgcccg 3205261 catgacagat catatccttg gctgttgtat tgacttccaa acccgccgct ttcatagcgg 3205321 cggtcttacg tgaatcatga atattaaaga tatagaacat gaggaaaatc attgtcacga 3205381 tcaattgcag cgtgccttca atcagcataa acagcgagtg atcttcaccg ggaacacttc 3205441 ccaatgtcat caatccggtt agcgcctgta taccgaaaac gcataattca aaagcaaaca 3205501 agcctgtgat ggcaagaaat aagagcccct ttgacaactg ctgattcgca atctgcccaa 3205561 gtcctggaat gatcgataaa agccctgcct ttcgtttttg ctttgtaagt gtgtgatgtt 3205621 tattcatttt tccgccctct attcttccgg acgctatccc gccgttttat ttcacatact 3205681 tttctttaat attttccttt atgacgttta cagcatcatt cgctgatgtt tgtgtcgatt 3205741 tttttcctga agctgcatca aaaattaaac tttccgctcc tgtccatact tcagccattt 3205801 ccggaatatt tggagtcggc gttgctgttt catattgttt aatcacagct gacgtcagtt 3205861 cattcttttg ctcatcggct ttcttccttg cagccgtgtt ggccggaact tcgtttgtat 3205921 cctcataaaa agcgtaagca ttggcatcat ttgcagcata ctcaagccat ttttcagcca 3205981 gctcgggctc ttttgtatat ttcgaggcaa cccagccctt cccgccagca aaaggggcgt 3206041 attcttctcc atttggcaat gtcggaatgg gagccgctcc gtagttcaat ttagcctctt 3206101 tatagttggc agctgaccaa ggaccgccaa tgatcgcagc cgctttgcct tctaaaaaca 3206161 tctgctgaat aaagtcgtct gcgcttgaat tgtcttgcat tcctttcggc caatatgtct 3206221 caaaccattt ctccgcatat ttcaccgctt ctacagcccc tttattgttc aggccgatgt 3206281 ccccggaatc tgtgccgttt tttccaaaca catatccgcc gtatccagcc aataagccgt 3206341 acgacatata aaagtcagtc cattttgcta aaaatccggt tgattttcct ttttccgaag 3206401 caaacgcgaa tcgaggatct tccgttaact tttcaaggtc tttaaatgtt tttggcgctg 3206461 tttttaaaag atctttgttg taatacaaaa taagtgtctc aatgactagc ggcattccgt 3206521 acactttgcc gtcaactgtc acctgctgca tttctttatc accaaagctt tttgtgttag 3206581 atggcttaat atcaagtaaa tgtccttgtt gtcccaaacc gccgatccgg tcatatgcag 3206641 caagcataac atcaggcgca ttacccgccg ggccatcaag aggaagcgct tctaactgtt 3206701 cgaacatttg cttttcaaca atttttactg tgacatcatt ttctttttcg aactttgttt 3206761 ttatgctttc aatgtattct ttatacgttt cttcgacaga cacagtcagc acctttttgc 3206821 catcagagct tgctggattt tttgaacttg agcaggcggc aaggccgatt gccaggaatg 3206881 atgccgccaa tatggcgaac ccctttttta aaagaaccat ctcttttcct ccttctattt 3206941 acgaaactat aacaattgta ttgtcctata gaaagcggtt acaacaactt tcgatttgtt 3207001 accgataaca gaatgttata caggggcggc agcactcaaa atcaaaaatt ctcccggctg 3207061 aacggcaatg acatcgtgat gctgtagcgg ctgctctgtc catgcatcac agattttctt 3207121 attcctatca atattcaact ctcgtaaact gacgtgttga accacattcc cttgattaaa 3207181 gaaataaatc agtatttttt catcaagagt ccgcgaaaag ctaatgaaat catttttgtc 3207241 gtccagcaga ttccactcaa gatgtccttc agtcaataaa gtgttttcct gcttgcgtaa 3207301 agcaattaac cgtttcataa attgcagcat gtcttggttt tgcttctctt tttcccaaac 3207361 catacatttc cggcataatg gatcattttc gccgttcagc ccgatttccg ttccgtaata 3207421 aatgcatggt gagcctgtct gggcaaacat aaaggccagc aacgcgcgtg ctttcttctc 3207481 atcattgcgg catctggtca aaaggcgctt tgtatcatgg ctatccagta aattaaacat 3207541 cacctcattg gcctgcttca ttccattcat caaatgtgca ttgacacggt gagccatacg 3207601 tgaagctgag atcgtctggt cagcaaagta ttcaatcata ggctctgtaa aagggtaatt 3207661 catcgccgca tgaaattcat cccctctaag ccagggttcg gcagaatgcc agatctcacc 3207721 taaaatataa acatcaggct tttcagtaga tacagcctgc ctaaatgtct tccaaaaaac 3207781 gtgatccact tcatttgcga catccaaacg ccagccgtca atgtcaaatt cgcgaatcca 3207841 gtacaaagca atatcaagca aatatttctg cacctcggga ttagccgtgt ttagcttcgg 3207901 catatcagct gtaaaagcaa atctgtcata attgtcgtct gtgacgggaa aagagtgaat 3207961 atggaaccag tccttatagc gggattgatc tccgtttttg acgacatcct gccattgcgg 3208021 agacgcgctt cctatatggt taaaaaccgc atcaagcata attctcatcc cccgctgatg 3208081 cagctggctg accaatgtac gaaaaagctc aggatccccg aaatgcggat caatagaaaa 3208141 gtaatccagc gtgtcgtatt tatgattaga aggcgcggaa aagatcggtg tcagataaat 3208201 gccgttcacc cctaaatcct ctaaataatc aagcttgtca acaattcctt gtaaatcccc 3208261 tccaaaaaaa tcattgacgt ccgggtcctt gctcccccac ggcaatgcat tcttcggtga 3208321 caagtcttct cttccatttg caaaacgctc cggaaaaatt tgataccaaa ccgttgactt 3208381 gacccattca ggcgcttgaa atgtatcagc ctcgtgaaca aacggaaatt taaagtaata 3208441 atgaatcgtt tccagtgttt tttcgttata agggcataca cccgaacttc cgaaaaagat 3208501 gtcttcatga tcgtctgtta caacaaacgc atattgtaaa cgcctaaatg gcggcaccac 3208561 ttcagcaaac caatagtcat gcatttctgt agcagcaatt ttcctcatcg gctgctcgtt 3208621 tgccgaccat ttgccgtcgt tgtactcata gggatcaccc caaatgaatc gaatgtgatc 3208681 tgcatcacct tttttcgtcc gaatcttgat atgcacagtc cgcccatcat aagaataagc 3208741 atctgtgctg aatggctggt gatgaatcgc tgcatattcc atcatgtttc cccctttgat 3208801 ttccgtttta ttgaagccgg ctcatagttt gaaagtatca tgatgaaatt gtgggaacaa 3208861 tccttttcac cctgttaccg ataacagaat aaggcgctta cagcgttgat tctcgtacaa 3208921 ttaactctgg ttcaaaaaat agacttcctt gtgcagcgcc gtcttcattc atttttttca 3208981 gcaacatttt cgcacaggct tcccccattt caacaacagg ctgtctgacc gtagtcaagc 3209041 gcggcgagga gatgcgatca agaaacacac cgtcattccc ggtaaccgca acgtcttctg 3209101 gaattcgctt tccaagggat tgcgccgcac gaatgacgcc gagcgcgatt cgatcagatg 3209161 cgcagacaaa tgcggcctga ttgtccatgg atttcagcag ttctcttgca aggcattcac 3209221 ttttcttaga actgttgtcg atccgaaaca tattcgattt tttaaagctt ttattcatcg 3209281 cccgtatata cccctgttct cttgcacgtt cgaaaggctc atctaaatca atgccaaaaa 3209341 agacaacttc ccgctccccc agccccataa catggcgggt tgccataaaa gtgcctttct 3209401 cgttattcac atcgataaag tcatagccca tttcattttg tccaaatacg acgagcggct 3209461 tctcaaaagc ttttattaca ccttcaaaat cgttctttct caagccggtg gcaataatgc 3209521 cgtcacattg gccaatatta agagaatttc ttgtcacaag ctggagagca tagtgattgc 3209581 gatccagctc cctgctgatt cctgtcagca ggttcatgta atatggttct gtcgtatcca 3209641 tttcctcaag tatcaatagt ttcacaacct gtgttctgtt ttgcacgagc gctctcgccg 3209701 cataattagg gatgtaattc agctctttca tcgcagaatg aacaagcttt ttcaattcat 3209761 ccgtcaccgt ctcagggtga ttgatcactc gtgataccgt cattttcgaa acatttgctt 3209821 ttttcgccac atctgacaat gttgccattt tcatcccctc cttatctgtg cttattatcc 3209881 aaactagtga taaagtcctc tattactgct aaatatacga tgcaggccaa agagaaataa 3209941 aaaagagatt tcccttaagg aaacctcact ttgttaaaaa cactcgattt ttcatggatt 3210001 catacgctag gtggcagact cattctctcc acttccatca gaaaatctct tttttaaatt 3210061 tctgtccact ttttttctaa aatcggataa gaataatttt gcatttgctc aattaactca 3210121 tccggccgtg acgagctgtg aatcagtttt aggtgcgatt cgttagaaaa cccttcttga 3210181 atgctgtatt tcaccatttt catcattggt tcaaaatatc cgtttacatt gtacagtcca 3210241 attggctttt ggtggatgcc gatctgtgcc cagcacagca cttcaaataa ttcttcatat 3210301 gtaccgaagc cgcccggcat cgagataaag ccgtccgcca gctcgctcat tttagccttt 3210361 cgttcatgca tcccgtttac ttcaatcagc tcagtcagat tctgatggac aacctccccg 3210421 ctgaacaaac cgctcggcat gaccccgatt gcagttccgc cgttttccat aatcgcgtca 3210481 gcaatcgtgc ccatcaagcc tacgcgggag cccccataga caaggccgat tccctgctca 3210541 gccatataca cgccaagctc tgccgctttt cttttatacg cttcatttcc cccagggttt 3210601 gatcccgcaa atacacaaat ggttttcatc ttgtcatctc cgcatctata tatcgtgtta 3210661 aacattcaaa aacacactat atattgtccc atcttcatgt gataatatca atatgaaata 3210721 cataaagaat gcaggagtga tgaggttgca gctggctgat gcagaaaaat ggatgaaaga 3210781 gttttacgaa aaaagaggct ggacagaata cggacctttt attcgcgtcg gctttttaat 3210841 ggaggaagcc ggagaactgg cccgggctgt cagggcgtat gaaatcggca gagaccggcc 3210901 ggatgagaaa gaatcgtcac gcgctgagca aaaacaagaa ttgattgaag aaatgggaga 3210961 tgtcatcgga aatatcgcca ttcttgctga tatgtatggt gtctctttag aagacgtcat 3211021 gaaggcccac caagaaaaac tgacaaaacg atttgagcat gcataaaaaa gcggccgcga 3211081 tggccgcttt ttttaacctg tgatttcatc atggtgatca aagaaatgct gctttcctat 3211141 tttgtgaaaa aggcctgttt tatgcagtag ctccttcggc tgcgattgca atcctacaat 3211201 catcagcttt ccattgtggc gtttaattcg attcataatg ttcccaagca ccgcttcagc 3211261 tgacgtatcc atatagtgca ccttattcat gagcagaata agggttttcg gttttttctg 3211321 tacatgctcc agcaatgacg attcaaggga atcaattgat ccgaaaaaca gcggcccttc 3211381 tatggcatac atgctgacag atggatcttc tctcttcgcc agaacaggat gcgtttcctg 3211441 attgtggatg cgggtcgctt cgctcattct tctgataaag aacacgaatg caagcagcaa 3211501 tccggttgcc acaccgatga ttaagtcaaa cagaaccgta agggcgaagg tcgccgccaa 3211561 aataaaggaa tcagcatttt tcagtctcag catgtttgcg acttccttgc gctcactcat 3211621 attccatgcg accaccatga gaatcggtgc catactggcg agcggcacat gggacgcata 3211681 aggcgcaaat acaagcagga caaggagaac gactacgccg tgaacgacgc cggaaactgg 3211741 ggaaaccgct ccgtttttta tattggtcgc cgttctcgca atcgctcctg tagccgggat 3211801 tccgccaaac aggggcgctg ccatattcgc aatcccctgg ccgacaagct ccttgttgct 3211861 gtcatgcttt gagcccttca tgttatcagc gaccattgcg gacaaaatcg actcaagtcc 3211921 tccaagaagc gcgatgacaa gcgcagccgg aaacagcata accattttat ccaaagtaag 3211981 ctcaggaaac tgaaattccg gcaaatggcg ggggatttct ccataagttg acccgatcgt 3212041 tgccatgcgg tcagggaaaa agacaaccgc gaccactgtg gaaataagaa gcgccaacaa 3212101 agcgcccggc actttaggca tcaccttggc ggatacaagc aaaatgacga gcccgatcac 3212161 agctgtcaaa atggcataca cgttaaaggt gccgagctgc tgcacaattt caaacatgtt 3212221 gtgatgaaag ttctcatgtt tttcaacatt tctcaatccg agaaaattag cgatttgttc 3212281 cgtaaagatc agcacggcaa ttccggctgt aaaaccgacg ataacgggtt tgggcacgaa 3212341 tttcattatt tttccgagct taaacagccc aaacagtacc agcatcactc ctgccataaa 3212401 ccccgcaatc agcagatttt ccaagccgta ctgcatgata atgccgaata aaatcgggac 3212461 aaaggcgccc gtcggaccgc caatctgata ttttgatcct ccaaacaaag aaatacaaat 3212521 ccctgctata acaacagtgt atagcccata ttcaggctcg actcccgagg caatggcaaa 3212581 cgccattcct aaaggaattg ccacgacacc tactacgata cctgcaatca agtctttctg 3212641 aaatttctgc aaattgtatc ccttgaatct ccctgagaat cgcatatttt gttataacct 3212701 cccttatgag tgattgttta taagctcagt ttcataaccg ttaatgacca catcaagttt 3212761 tcctgtttca gggtgaatga caagcccgtg aaccggcact tttttcggaa gcagcggatg 3212821 gttcttaatc atgttcacac tgtgggaaac gctttcttcc acgctgtgaa aaccagtcag 3212881 ccacgttttc aaatcgagtc cggcactcgt cagcaaattc aggcagctat cctccacccc 3212941 gcgttccttt gctttctcaa gaatcgagga cgcattcagc cctgacattc cgcattcatg 3213001 atggccgaca atgcatacct cttcagcctg caattcataa atcgcgacca gtatgcttcg 3213061 catcacgctt ccaaatgggt gagaaacgat ggctcccgcg ttttttacaa ttttagcatc 3213121 accgttttta agccccattg cttgcggaag aagttctgta agccttgtat ccatacaggt 3213181 gacaatgacg agctttttcg aaggaaactt tgtcgttttg tacggttcat acttcttctc 3213241 actgacaaac cgctgattgt gttccaaaat tgatgttaaa gaaaccattt gattcatctc 3213301 ccatccatat gattttgcaa gccttcttac ccagcttaca gtaaggaatt atagcatagg 3213361 aataagccaa gaaaaggttt tcaaaaaaag acactataat tggactgtag aatcaaaaca 3213421 taaacattta tatctttcaa agataataaa atttatattt aatgcatcct ataatccggc 3213481 tgcagttcgt atatcgatga tttgtctgac aaaaaatatg ggtgaattct gataattaaa 3213541 aaactttttt aagcagattt agctgttcga tcttcatttt aagttcaaaa gaaccagaaa 3213601 ttaaaaaaac gcagctatat ttttaacatc tatttatttt cgatataatg aattagacaa 3213661 cagccataaa gggggagcct tgttgaaacc atttgtattt atcacaaaac cgattcctga 3213721 agagattgaa gcattcatcg gtgaacattg ccgttatgaa gtatggcagg aggatacgct 3213781 tccgagtgac gtgctatttg aaaaattaaa agaagcggag gggcttttaa catcagggac 3213841 gtccggaccg tcaatcaatc gtgagttgct ggaacacgcg cctaagctca aagtggtcag 3213901 caaccaatca gtaggctacg ataacttcga tatagaagca atgaaagaaa gaggagtcgt 3213961 cgggactcat acaccttata cactggatga cacagttgca gatctggctt tttcactgat 3214021 tctgtcttcc gccagacgtg ttgccgaact ggaccgtttt gtcagagcag gaaaatgggg 3214081 aaccgtggaa gaggaagcgc ttttcggaat tgatgttcat catcaaacgt taggcattat 3214141 cggcatgggc agaattggag aacaagcagc gagacgcgcc aaatttggtt ttgatatgga 3214201 agtgctttat cataaccgac atcgcaaaca agaaacagaa gacagcatcg gcgttaagta 3214261 tgcagagctt gatacattgc tggagcaatc tgattttatt cttctcatta cgccgctgac 3214321 tgatgaaacc tatcacatga taggagaacg cgaatttaag ttgatgaaga attcagcaat 3214381 tttcgtcaat atttcccggg gaaagacagt tgatgaaaaa gcactgattc gcgctcttca 3214441 ggaaggctgg atcaggggag ccggcttaga tgtatacgaa aaagagcctg tcacccaaga 3214501 taatccgctc ctgcagctgg ataatgtcac gctgcttcct catatcggtt cagcaacagc 3214561 taaagtgcgc ttcaacatgt gcaaacaggc cgccgaaaat atgctcgcag cgatccaagg 3214621 gcaaacaccg aaaaatctta caagagaatt tcaataaatc aaaaatccgg tctgataaca 3214681 gaccggattt catattacat acgctgaaga acagcacgct tataaatatg acgggtgacg 3214741 atataataaa gagcctggaa tacaaaataa atgaagatga caattacggc ctcaagaaat 3214801 aaattggaat tcagcatatt acttaacgct gcatacgcaa agcccgcgtg aatcgtacct 3214861 gcgataaatg ggatgaagaa taaaaatcct atttgctttc caaggatcga gtgaatctct 3214921 ttgtccgtaa cccctatcct ctttaacgct aacacctgca ctcccgtatc ttctatttcc 3214981 gtaaacatcc gcaaatacag catgcttcct tgcacgataa aaaacagcac gctgacaaac 3215041 agaccaataa acagcattaa tgcaactccc tgcttcacaa tttgataact aggagcacgt 3215101 gtttgaaaat cagatgtatg ttctttcggc accatgtttt caagcttttc agagacatcc 3215161 accgtctcct gccaatgctc aagctcataa cctaccattc tcatctgttc cttcagcggc 3215221 acatcctgtg acagactgtc aaagctcttt tcgctgacaa ccaataaacg gctgactcca 3215281 tcgacagaca tcaatatccc tttgttttgc tgctttttca tgacatagga aagggttttt 3215341 cctgacttca tatgaaatgc tgctgtttcc ccttctccaa atgtgtcttt caccatcatt 3215401 tgaaaagaaa cattaataaa tgcttcattt tcttgtaaat gaataactgg gaaccctttt 3215461 tcctttgcga cttgattata gactttttct gaaatcagca aagcttcagc ttccatcttc 3215521 ttatttccat acggcaagtc tgactgaaaa gtgacaggaa tccctgtggc atccacctta 3215581 tacgtgataa cagcatgagc ttttttcaat gtattctcag ccgtctcagg cttcatgacc 3215641 tgaaagcggg aagcatcctt ttccacccag gaaacagact gaggaatgct ttgctcctcc 3215701 tgcctttgta aatcggaata aaacatatag atgacacctg tagctgttag tatgaccgct 3215761 gtaatgacag aggttaaaaa cagcatgcgt gcatgatcct tcagcctgaa tatcatgttg 3215821 gaacgcacaa tgatatttgt gcctttgtag aagctgtgtt tctttcggta cagcatgcgg 3215881 aaaaatgcca cactgctttg ggtaaaaaag aaatacgtgc caattaacac taaaatcaaa 3215941 attggaaaaa cccgaaacat catgtcaatt gcattggctg ttgcagatag ataataaccg 3216001 ctgccaagac atagcaaaga caatacagtg agccatttcg aataaactgg caaacttttc 3216061 ggctttttgg ctgatttaat cagttcaatg atttccagct tccgaatccg tcccagtgat 3216121 aaaatgagca gcgtctgaaa caggatgaga aagccggcaa ttgtcatcac aaacgctttc 3216181 ggcacaatgg caaacgaaat cggcaccttc acgctgagca tccatgtcat gatcataaaa 3216241 aacagttttg aaaataacag gcctgctcca atgccggccg caatcgccgc aagagaaata 3216301 agtgactgct cataataaat catcttgcga agctgctgct ttgatgtgcc aaacagtgtc 3216361 agcagcccaa actctttctt tcttgcctgc aaaaacgctg aattggaata tgtgatgaaa 3216421 aatatacaaa acacaatgat gacgacaaga gctgcgctca agcatgtttt gacaaggctt 3216481 cctccatata tattgtcttc attgacatca ggatgaaaaa taaatgatgt gaagacaaaa 3216541 aacaccgaaa cggcaaacac acagcttaaa aagtaggcca cataccgttg cagattccca 3216601 agaatgtttt tacgggcgat agttctcaaa ttcatgaaaa tcgcctccca acacactcaa 3216661 ggtatccaat atactttgat aaaacacctg cctgtttgtt cctctgtgaa tctctgaaaa 3216721 gaaacgtccg tctttaataa aaacaatccg tttacagaaa cttgctgctg tggcatcatg 3216781 cgtaaccaac aaaatcgtcg cttccttttc ctcattcagc tgagccagtg tgttcatcac 3216841 ttgctttgcc gattttgagt cgaggtttcc tgtcggttca tcggcaagaa tgagcgccgg 3216901 attgtgaata atcgctctgg cacaagctgc ccgctgctgc tgtccgcccg acacctcata 3216961 tgtgcggtga tcgagaatat gctttatttg cagcgtatcc gccagttcat ccaatcgagc 3217021 ttccatttct ctcagcttta ccttatccaa tgcgagcggc aagagaatat tttcacgaat 3217081 cgtcagcgta tcaagcagat taaaatcctg aaagacgaag ccgagttctc ttctgcgaaa 3217141 caaagccagc tcttggtcct ttaacgtttt cggctgaatg ccgttgatca tcatctcgcc 3217201 ctgggtcggc ttatcaatgg tagccagcaa attcaaaagc gtggtttttc cgcttcccga 3217261 cggccccata atcccgacaa attctccttt tgacacactg agatcaaagg cgctgagcgc 3217321 ttggtatgat attgttcctt tatttgaata gtatgttttc gataggttcg ttgtttgcaa 3217381 cacgttcatg ttctgctcct cctttttctt tattataaaa aggaagtcag catcctccca 3217441 tcgaactttc ttgcaattcc gctccccaat cttacaatgc tgtcacattc acgagggtgt 3217501 cacttgaaaa cacgatggtc atcacagtgc cagccccttc ttttgattcc gcatacagct 3217561 tatggccgag acggctgcac acctgttttg ctaaataaag gcccattcca gttgcctctt 3217621 tcatggttcg tccgttttct ccggtaaaaa acgcgtcaaa aatccgcggc agatcctgcg 3217681 gcggtatgcc gattccttcg tcggcaaccg acaagcgcgt ctcatgtccc tgtgtttcaa 3217741 tccggattgt aatagggtct cccacacctt gctttgaata ttttaaggcg ttgaaaagga 3217801 tttgctcaac aacaaaggaa agccactttt gatcactgga aatctgaacg gcatttggcg 3217861 gcacatgtaa tgttggaaaa aggcgccgct tgataaactg acgtttttcc tgattgatca 3217921 gtgaacgaac catttctgcc aaatcaaagg tttgcggctt tacatcaaat gcaaattcct 3217981 ccagccgggc cgtttgcagc atcatatcaa gaccgtggcg aaatctctca ttctcatcct 3218041 ccagctcctc taaaaacgtc ggaaaagagg atgaggttcc gttttttcct tcctgaatca 3218101 ttaaggatat gacagatacc ggtgttttca tatggtggac ccattggttg gtgaaggtgt 3218161 aatgctgttt ttgctgattg atatattgtg agagcctgct ttcgtattgc tgcccgagtg 3218221 cgttgatcat cttcgtccaa agcgcttgct ctcctgttct tggctttctg gctttcaaag 3218281 actgtccgat gtcattcgaa gaagaggctt gttctgcaag ctttttaaca tatgtgagaa 3218341 aggaaaattg ccgaacataa tcagcagcaa aacctgcggc taaaagagta ccgggcaaaa 3218401 tccatatgta catcatattt tctttggaag gttctgcgcc gctctctaca atgcttaaat 3218461 acgcaatcag catggcggac cctatcccta ataatgaaaa tagaataatg gctaagcggt 3218521 cgatgagata agtctttaac attccgcttc atccttccga ttgacttgaa attgataacc 3218581 ttgtcctctg attgtggaaa tgcaatctgt cagtcctgca ttctccagtt ttctccgcag 3218641 ccgattgaca ttgaccgtta acgtattgtc atcgacaaaa tcaacgtcat cccataacgc 3218701 ctccaatagt tcatcacgag agacaatttt tttatgctcc ctcacaaaaa tcgagagaag 3218761 ctggaattct ttttgggaaa acaaaatccg gacgctgttc cattcggcct cattctgatc 3218821 aggataaatc gtcagcccgc caagctccac tattctagat tcctgcggca aagagggcga 3218881 atattcacca tatgtgcggc gcaggacgct tttgattttg gccatcacta cctctagatg 3218941 gaacggcttt gtgatataat catcgccgcc attttcaatc gccattacct gattcagctc 3219001 atcggtccgt gccgatataa agataatcgg cgcattggaa atggtacgga tttgcctgca 3219061 ccaataaaac ccgtcaaaaa aaggcaggtt gatatcaagc agcacaagat caggcttcat 3219121 ttctgcaaat tccaatttta tatcattcag ctgttcagca attttcactt catatccgta 3219181 tttttgaaga tgaccgccca gcaaagaagc aatccgctca tcatcttcca caagcaaaat 3219241 ccgatacacg ttgatccccc ttatatgtac atcacgatga tttttctaga agattccaaa 3219301 attattatag catgtgcgga atagtaaatc ggtctttttc tttttgttat gatagaatga 3219361 taaaggtaaa attttcataa taggcaggtg tcgtgatgaa gaaaatcatg ctgtttctgg 3219421 caatgacgtc aattctttca gcatgtcagc ccaactatac cgggaaatac atagaaattg 3219481 gggatacact aactgactat accaaagagt gctttaaaga gaatgaaatt ccttataaat 3219541 acgaaaaggg aaaactgtat atcccagaag acgcatttga tacagcaatc tacacttgtt 3219601 cataagaaaa agcttgcaga taacctgcaa gcttttcacg ttacaaaaaa tgagtattta 3219661 atttctcttc aaatcctgaa gggccgatgt cgcttttttg aatgttaccg ccgttttcat 3219721 aaatcgtaaa atggcgctct gacatgacca tccttccgct cggcgtcagc tttgaggcaa 3219781 gcagggattt gttaaaagga gatttttcat gagagtgaat gatgtccttc atgttatcta 3219841 aatcaccgag atcactctct tcaagggtaa aggcgtaccc aatttgccag ccttctcctt 3219901 tgtccatcag cagaacatag ctgccctttt ctgtctcttc ctttttgatt cggaatgacc 3219961 cgactggtga ctgtaccgtt tctccggaaa gcggtatcgg ctggagcgcc aggttgatgc 3220021 cgaagccgat atcaacgagg taatcgccgt tttccgcaga cagccataca gcagcatgcg 3220081 tcccttctag tgcccatccc tcttgatcgc ctgcataaac cgttcctcga atgagcttca 3220141 catgaaaccc ggcctcacgc aagacaaaat aaaggaaacc atttagatcg tagcataggc 3220201 cgccgtgctg atctttgagc agacgtcgcc atagctcttc ttttgtgatc ttataattct 3220261 cttttgcaag tacggcacgg ttttcgaatg gaaaacggta tgccattgct ttaagaaaaa 3220321 ggggaagatc gccgaagctg acatggtctt tctcccagcc gattttctga aagcagtctt 3220381 ttagaaagtc actcattttt atcacctaaa cttcttcttg aacgtaagca gccagcttct 3220441 ccagcgcctc ttgttcatct tctccctggg caatcaaggt aacctcagtg cctgtgctta 3220501 ccgcaaggct catcagcccc atgatgcttt tggcgtttac ttttttccca tccttctcaa 3220561 gaaacacatc tgacgtaaac cggtttgctt cttgtacaaa caaagcagca ggacgtgctt 3220621 gcagtcctgt ctttaatcga acttccactt tctgttgaac cataagatct ccccttttct 3220681 ttacggttat tttaaagtga cggtttgccc tgtccgcagc tgttctgcga tttcgtcaag 3220741 ttttctcagc ctgtgattga tccctgattt gctgattttc ccgcttgcta ccatttcccc 3220801 tagctctttc agcgtcactt cctgataatc aatccgcagc tgcgcaattt cccgaagttt 3220861 ttcaggcagc gcctccaggc cgattctttc atcgatgtat ttaatatttt ccacctgtct 3220921 cagcgatgcg ccgatcgttt tgtttaagtt ggctgtttca caattgacga ggcggttgac 3220981 cgaatttctc atgtcccgaa cgattctgac atcctcaaat cgcagaagcg aattgtgagc 3221041 gccaattacg ttcagaaact ctgtaatctt ttcagcctct tttaaatagg taatatagcc 3221101 ttttttccgt tcaagcgttt tgctgtttaa ctgaaactca tttaacaggt cacataatga 3221161 atcgttatgc tccttataaa gagagaagat ttctaaatga tacgaggagg tttccgggtt 3221221 attgaccgaa cctcctgcca aaaatgctcc tctcatataa gaacgcttgc agcatctctt 3221281 tttgaccagc tctttcgaaa tacttcgttc aaacacaaaa ttctccccga gtatttttaa 3221341 atcctctaag atcgcttttg cattttctga aaaacgcaca atatagacgt tattcttttt 3221401 cagccgcatt ttctttctga ccagcagctc gaccgacaca tcatattgtt ttttcagcaa 3221461 tgtatagatg cggcgggcaa tcgccgcgtt ttcggtttga acatcgagta cgagatggcg 3221521 gtttgtaaat gataaagctc cattcatccg aatgagtgca gacagctcgg cattaatgca 3221581 gcagtccttc acttccagat tcgttaattc tttttttgtt tctgatgcaa atgacatata 3221641 gccacctcat ttcaaggctt cattctttca gtaaatcaac aagaagagag gccactttat 3221701 gtgtatcgtg acgtattacg tcatttttat acgttacaat ttgatctctg atgacttcaa 3221761 gccccatcgc tttcagctct tcgatatcaa aatcaacagg acgcgccgat tccatttcgt 3221821 acttacgttt tatttcgtcg ggaatgtctt cactgttcac taatatcgta tcaataaaac 3221881 cacagcccat atgctgattg agcgctttca catgatcagc agcggtgtaa tggagcgttt 3221941 cgccgggctg agtcatcacg ttgcaaatgt atactttttt cgccggcgcc tttatcactt 3222001 cttccccgat ttttgggacg agcaaattgg gaagaatgct ggtatagagg cttcccgggc 3222061 cgataataat caaatccgct tccctgatta cgtctattgt ttccggcagc ggatcaatct 3222121 gttcaggcgt gagaaaaaca cgcttaatgc gctgtccgta ttctgggatc gttgactcgc 3222181 ctgagaccac gcggccatct tccatctcag catgcaaaac gacactggca ttggcagccg 3222241 gcaaaacctt tcctcttaca ttcagcacct tgctcatttc tgtgacagcg tgaaaaaaat 3222301 caccggttat atttgtcatc gctgccaaaa tcaaattccc gagagaatgg cctgttaagt 3222361 cattcccttt attgaagcgg tgctgaaaaa gatcttcaac aagcggctcc acatcggata 3222421 aagcggcaag cacatttctg atgtctccgg gaggcggaat tttcagttca ttccgcagac 3222481 ggccagagct ccccccatca tcggcaactg ttacaatggc cgtgatgtca acgggtttat 3222541 gctttaggcc ccgaagcaat acagaaagac ctgtaccgcc gccaaagatt gcgattttcg 3222601 gcttttgtcc catcttattt ccggcttctc ttttcaatgt cccggtgagt aacatgagta 3222661 tagtaatcct ttttgaaata atcagctaaa ttctcggcta atgtcacaga gcggtgctgg 3222721 ccccctgtgc agccgatcgc aatgacaacc tggctttttc cttctctttt gtaagatgga 3222781 agcataaagc tcagcagatc aattaatttc tcattgaact tttgcgtttc attccacttc 3222841 atgacgtaag aggaaacctc tttatccttg ccagtcagcg gccgcatgct ttcgatatag 3222901 tacggattcg gcaaaaatct gacatcaaag acgagatctg catcaattgg aataccgtat 3222961 ttaaaaccaa atgacatcac atttacggta aatgtctctc cttggtttgt cgcaaagtgc 3223021 ttcacgattt tttcacgcaa atcacgcggc ttcatgtcag acgtatcgta aatgatttga 3223081 gagcggcctt ttaattcctc aagcagctct cgttctagcg cgatgccttc aagcggcagg 3223141 ccagtcgctg ccagcggatg cgagcgtctc gtttctttat atcttgtgac gagaatggaa 3223201 tccttcgcgt ccaggaataa aattcgcggt gtgatccacg gattttcggc catttcatcc 3223261 agcgcttcaa tcagccggtc aaaaaattcg cggccgcgca aatccatcac gagcgcaact 3223321 ttgctcattt tcgaatttga ttccttcatc agctctaaaa acttcggaag caatgaaggc 3223381 ggaagattat cgacgcagaa atagccgaga tcttcaaagc tttggatcgc gacagttttc 3223441 cccgctcccg acattccagt tataatgaca agctgaatat catgtgattc actaacactc 3223501 atctttctcc cccctgactt gtctttctat ttgatgtgct gcgggtctaa acgataactg 3223561 agcagctcaa attccggtgt atacgtaaat gtgccgtgca gcagcccttg tcccttcatc 3223621 ataaaatcaa ggatatggcc gtctccaggg gccataggca ggttctgaat gtcattgaca 3223681 tcgtgccact gcagtttgcc ttcctctgat tctgatacat tttgtcctgt atatgaatca 3223741 gcgacaaacg taaacatcat ccactcggag acaatgtggt caccgtcttt aataataaag 3223801 gtaaaaacgc cttttaattg aggatttatg atatagatac cagtctcttc tctgtactct 3223861 ctgatgacgg agtctctgac tgattctccg ctctccatct tgcctcccgg cgcgacccac 3223921 catccgcgtc tcggcttttg aagcagaaga actttgtcat ccgtctgaag cacacaattt 3223981 gtcactcttt gcaagtacgt cacctaacct tcgtcctgtc atcgtctctt tattataccg 3224041 cttcaagatg cctcccacaa tgaagagaca ttgacaatct tttcttctat tttacagcat 3224101 attcattcct taattcagat gattttgctg taactggaat tctcttttat ttatggacaa 3224161 aaaaaggaca cggataactg gagaatccgt gccaaaaaag tgtattcatt ataaaaaggg 3224221 ggtcaattac tttattaatc ataaccgaaa agcattacac atgtgttaca gcggaattaa 3224281 aacccagtaa cgtaatgtga aactcgtatg acagcccttt ttattttaag gttttcagcg 3224341 tttcttggag ctcttcgaca taatgttgta cgctttgtgc cgcaatgctt ccgtctcctg 3224401 tagccgttac gatttggcgc agtgattttt cgcggatgtc tccggcagcg aaaatccctt 3224461 caaccttagt ttccatgcgg tcgtttgttt cgatatagcc ttcttcattc gtaatgccca 3224521 ggttttcaaa cggtttagac agaggaagca tgccgatgta aatgaatacg ccgtctgttt 3224581 tgaattcact ttcttcaccg gttaccgtat cgacaagcgt tacgttaccg actttgccgt 3224641 tttcctcatg aatttccttc acagttttgt tccataggaa gtcaactttt tcattatcaa 3224701 atgctctcgc ttgaagaata ctttgagcac ggagtttatc acgtctgtga acaatcgtta 3224761 cttttgaagc gaaacgagtc agatatacgc cttcttcaac cgcggaatct ccgccgccaa 3224821 caacgacaag ttctttgcct ttaaagaaag cgccgtcaca tactgcacaa taagatacac 3224881 cgcgtccgcc caattctttt tcgccaggca cgccgatttt tttatattcc gcacctgcag 3224941 caatgatgac agcacgggct ttatattcct ttgaaccagc tttgactact ttgtactctt 3225001 tgccgtcaat gacctcttta atatcgccat aagcgtattc agcgccgaat tttttcgcgt 3225061 gttcaaacat tttgttagaa agctcaggcc caaggatact ttcgaatcca ggatagtttt 3225121 ctacatcttc cgtattggcc atttgtccgc caggaattcc tctttcaatc attaatgtcg 3225181 ataaattcgc tcttgatgtg tatacagcgg ccgtcatccc agcagggccc gcgccgatta 3225241 taatcacgtc ataaattttt tcttctgaca cactattcac tccttaaacc atcttttcaa 3225301 gtttgggctc tttcttataa gataagaatc cccatcaaac gtattcctta cccatatcct 3225361 ataaaatctc atggtgatac gctatttttt tgctcaacac gattaaatgt attcgaaaag 3225421 ggtatatgtt aataaagaaa gagccttctg tttatagaag gcccttgtca tatttattat 3225481 tgaacaacac gtcttacaac acctttaaat gctgctttcc agtaaggatt gctcatagag 3225541 tcaacagata cgccatgaga tgtattgtcg tttaggaaag taccgtttcc taagtagatt 3225601 cctacgtgtc catttgtttt gtaagtgtca aagaacacaa ggtctccgcg tttcatttca 3225661 gacgcgctga cagcttgtcc tctgccaact aacgtatcag ttgttgttcc gcctacaggt 3225721 ccaaggttaa cacctgcaga agcgtatgcc cagcgtacga atgatgagca gtcaaaaata 3225781 cggttgttga tatcagactg agtgcgtccg ccgccaaact tgtacggaga ttgtcctaca 3225841 atgcttgaac caacgctgat cgcgccttca attccgccag agttgctgat aacagtgccg 3225901 cctgaattgc tgtttgagcc gctgctcttc ttagaagatg agccgtttga cgaactgttt 3225961 gatgaaccgt tagaagaatt gtctgaagaa ttgtctgaag aatcatcaga tgagcttgct 3226021 tttgatgatt cagttgtcgc cgtttgactg tcatctgttt gtgtttcatc agatgctttt 3226081 tgtgcttctt cctgcttttt gatcaaagca gccgctgctt cttgttcttt tttgatgcgt 3226141 gcttgttcag cttcagtatt tgctttttga tttgcaagtt cagacgcctc tgattttaat 3226201 tcagaaatcg ctttagccgt tttcttttgg cttgcttttg cttcgtcgaa aagcttgtct 3226261 ttttcattaa gctgtttatc aaggtctttt tgcattgttt ctaatttagc caaggcagct 3226321 tgaacttctt tcagcttgtc attcaaatcc gcttcagaat cttcgagctt cgctttatcc 3226381 tgctcttgct gtttgattaa atctttgtct gcgtccacaa tagatgaaac cgcagtcgca 3226441 cgagagataa agtcaccaaa gcttgttgat cctaaaagaa catctatgta tccttgagat 3226501 ccgccgcttt cctgtaaaga acgaacgcgt tttttcagga tttcattgcg tttttcgatg 3226561 cgtgcttcag tttctttaat ctcttttttc agttttttga tttcttcttt tgttttatcg 3226621 ttttcttctt ttttatcttc aatcttgttg cttgtatcaa gcgccttatc gttaatgtct 3226681 ttcagttctt tttcaatctt tgattgattt tcctgaagct cggttaattc tttttccttc 3226741 gcttcaatgc tggaagcaac ctcagattgc ttgctttcga ttttttgttt cttttcatct 3226801 aatgtttccg ccgatgcagt tttacttgta aatgggatca aaaaactgct tgtcccgatg 3226861 acggaagcca aaccaagtgt aattaaactc tttctcactt tttatatcct cccttttact 3226921 gtgaacctgt cctcatttgg aatcgtattt tgaacatcaa gtttcgttcc tcatactcta 3226981 cgaggaatga tggttgttta tggttaatta ttctgtgcat ctcttattct ggttgtatag 3227041 cgtttatttc acatcatatg taaaaaacac taattcctta tgtacgagaa tcattatacc 3227101 atcaagtttc gacaaattag cgataaattt tattacattt atgtttcaaa cagatgtcaa 3227161 gtcacacatc atttgtcatt tttcttaagc gtgtaaaaaa actgtcgata ttattttctt 3227221 aatataatct atctaacaaa aaaagagtcg attaaataaa tcaactcttt aaaatttact 3227281 attctagaat atcatcaata tatttcatat atttcgtcaa agttgccgga gagatgccga 3227341 atcgggccgc tgtgtctttt ttcgtgtctt gcttgccatg ggcttctttc caaatataac 3227401 agatggctgc tgcccagcct ttctcattct tcaacggagc agctgcacga atttgctgga 3227461 tgacatgaaa aacccagcag ctcatgactt ctgttttcat ctcttctttt tcagcttgct 3227521 ctaatagttt gaccgtttga taagcgaaaa gtgcatcctc tgaaacgtca gcagccgcag 3227581 aatctccatt cagaagcagc tttacaaaat gagtttcaaa aggagcggta attctctttg 3227641 agcgtatcac cgcttcaaga tgctctgttt ctccctttgt gctgctgata taataggctg 3227701 cgagtcgctg ctccacagat gaaggaagag cttccctccg ctcaatccaa ggcgccgggc 3227761 ggtcttcgcc gggatattgc gactcgactt ttctccagat cgtctcggca aagtcggtat 3227821 gtcccgtaaa ataagcagag caggaaagcc agtaaaagaa ggtgtcgtca ccctcaaagc 3227881 cggttttata taatgatttg agccatttat atccgatctc gtagcggccg acaagcgcca 3227941 aagtagcacc caatttataa cgctgctcca atagcatcgg atagacattg gagagctgat 3228001 cactcaattc cgccactttt tcgtcttctc tttcataata gtagaaaacg agaagattgc 3228061 ataaggcgtg aagatttcct tcattatgag aaagcacttc ataagcggtt tgcttcgctt 3228121 ttacaacgtt tcctgaatag aaataggcaa gcgcgagatt gttgtatgct gaccaaagct 3228181 ccggatattc agttgtgatt tcctcaagcg ccgcaaccgc ttcagcaagc tggccgcttt 3228241 ccagcaatga ctttgcccga tcctgtttca ccagcagttc atcctgatca tacaacgaat 3228301 cctcaatgcc gtcgtctcct aaatcgagca aatcaagcag actatcgttt tcttcggcga 3228361 attcaccatc cgggtccgca tcagaataag cggccgcttc tttataagct tcctggaaga 3228421 gccccagatg ggcaaagtta ttcgctttaa agtaatggca ctccggcatt tcggcctcca 3228481 gatttgccat gatatagtca agaagatcgt tcgactcttg atactggccc atttccgaat 3228541 aaatgaccgc aagctgtgaa agcatctctg aatcctccgg ctccaaatga accgcgcgct 3228601 gaatcagttt gcttgcccgt tttagattgc gctctttata cgctttcaag cctttatgaa 3228661 aaaaatattg tccatcttga agcagctgga caatttgtgc gtgattttta tgttcagaag 3228721 tgtgttttcc cacaactacc ctccgtttta tacaatatta ccgtcagtag tataccataa 3228781 atcgtaagcc cctcaatagt tcaaaaggaa ggattgggaa aatccctcct cttttttatt 3228841 ggctgattcg accaaaattt acccggcttt gttttctaag tccgcattca ttttcagctg 3228901 ctgttcagca aaatcccggt aaaggccatg ggaagccatt aactcatggt gtgttccacg 3228961 accggtaatt tccccttttt caacaaacaa aagctggtcc gcatctacaa cggtagatag 3229021 gcggtgagcg ataacaatcg ttgtgcggcc ctccatcagc acctccagcg cctgctgaac 3229081 tgatttttca gattggctgt cgagacttga ggtagcttca tcgagcataa gaatgcttgg 3229141 gttacggaga agcgctctcg caatcgcgat tctttgcctt tgtccgcctg acagcataat 3229201 gccgcgttcg cccacttctg tatcaaactg attcggcagc tcctttataa aattgagcgc 3229261 atatgccatc tccgcggctt tttcgatctc agcatccgtc acatctcgtt ctaacccgta 3229321 gcaaatattt tctctgattg tcccggacat taacgggctt tcctgtgata catacccgat 3229381 atgctccctc cacgattcaa gcgagtaagt atcgaccggc tcgtccccca gccgaatggt 3229441 ccctgcagtc ggagaataaa agcgttcaag cagcttaaac agcgtcgttt ttcccccgcc 3229501 gctcggaccg acgatcgctg tcactttccc tgcttcaatg acggcgctga cctcttttaa 3229561 gatcagctga tcaggcttat atccaaaaga cacgcgatca agctggatag gcagatgtgc 3229621 attttcaatt tgttttcctg tcactgtatc ttcctcttcc tctgccaaaa tctcaatcat 3229681 tcgttctgtt gcaccgattg atttttgcag ctgtgtgaaa aacgttgtaa tctggcccat 3229741 cggcataata atttgaaaca aatataaaat aaaagccacg agcgctccgg ctgtgagctc 3229801 gcctgatgag acctgcatgc cgccatatcc gatcactgcg acaagcgctg ccattaacac 3229861 gagtgaaata agcgggccga caagcgattg aaccttggct tcacgaacgc caagcttaaa 3229921 taatgaggaa atccccatct tcccgcgccc atattcgaca tcctccgcat ttgaagcctt 3229981 aacaagtctg atttccggga gaatttgatt aagcaggcct gtaaaacgag ccgtttcatc 3230041 ttgcgtttcc cgtgaaatgg agaacatttt ccgtccaatc ggcaccaaaa taagagcggc 3230101 cagcggaacg accactaaca caagcagtgt cagcttccag ttcataataa acaagattgt 3230161 caatgatcca atgacagaaa tgatgcctgt aataaatccg ctgatatggg ttgtaatcaa 3230221 ttctttgacc accatcgtat cgttcgttac acggctgact gtttctccgg aagcatttgt 3230281 atcgaaataa gagacaggca gcttaattaa tttcttccat aataactccc gcagcccgga 3230341 aatgattttt tgtccattat agttaagcgc ataggtggca taagcgctta aacccgcctg 3230401 aacgaaaaac accagcgcga tcaaaccgat ttgcgtgcct gacagatttg acatagaaaa 3230461 accatcgaca agctgcttcg ttaataatgg aatgagcagg ctgaccagcg tggttactac 3230521 actgagggca agcgcaaagg cgagctttcc ataagaagga ttggtccgtc ttactaaggc 3230581 aaaaaagggt ttcaatttac ttttagattt ttgtttcttg gttggcatat attttcctcc 3230641 tgtttcagcg ttcagaaagg tgaaaagtca tagcaaaagg atgattttta ctctttctca 3230701 atcatatcaa tggagaaaga ctttttcagt atatttttgc cgtgatcaaa ataaaaatct 3230761 cccactcatt gtttgaatag gagatttttg tgttagacat ctttcactgg cttctttttt 3230821 ctgtaagtca atgttacatc ctgctgtcgc aggtcttcta ttatcatttt gtaccgatca 3230881 acttttgcgg tatgttcttc ttttatcatc tgaagggcag cttttcgttt ttcgctatta 3230941 gactcaagct ctttttttat tttttttaca atcaaccctt tttgcccttt gatttcctct 3231001 tttaatgaag actcaaattt ctttgtcagg ctgagaaagt cgttgatcgg ttgattgagg 3231061 gtgcccgctt tccccttcat ttcatcttgg gtaagaaaca tataggtcgt tgatacaatt 3231121 tctgtttcac tttctgaaaa taaggaagtc actcttcata ttcctcctaa gactgaaaat 3231181 caaataactg agaaatcatt tcttcttttt caaacagctt ttcaatactc tcgcggatat 3231241 ttttgataaa atctcttttt tctgttgtct gtttttttaa ttcagcaaca attccatcat 3231301 ttgcaggaag cgcacctgtg tggaatgatt catgaactga gattttctcc aatttatcga 3231361 atgtgtggct gaaaccagct gcaagccgga attgaagatc gaaggcataa tgcgaagggt 3231421 tttcttccat atgatgaata gccgtgatga tcgcctgctt tttgtctatg aagtcttcat 3231481 cgatttcctg actgtaaacc ttctggtact tagaaatcgc atcttccata tcttcaacga 3231541 ttttcatacc gttttgatag attctgacag cggatgagag attgacttga atcgtttctc 3231601 ccgagccact cttccctgta aaataaatat cggagccttt atagctgaag cctttttcct 3231661 ttgacaaggc gttgagcatt tgaacgatgc tgtggccgtc gacgataagt tttagtgcgt 3231721 cttttgtttc tgtgtcgagt gttttcaatg aggacagaat tgattttaca tagtccacta 3231781 tttcaccaac gtcttttaaa gcttgcataa attggccatg ttttagatgg tctatgaaat 3231841 gttcgtaccg tgactctatg cctcgcatac tcgcattaat attcgttaat tcttttttga 3231901 tgactttctt ttgcgtttca tcaatataac cattttcagc taactgatct acgaccggtc 3231961 cgctgtttct caacaaggta tgaagaaaac ctaaaaacga cggcagttcc tcttttattc 3232021 ggccatacat ttgcttaaca tcatcaaaat gctcatatag gacacttact ttctttaaag 3232081 cgccgtctgt gtttttcact ttttcaatca ggtctatgtc tatcccgctg gctgccttta 3232141 taaaaccgtt caagccgtct ttttcatagt catccttata tttttgaagg aatttttgaa 3232201 ttgacctcac atcttcgtca ggaaccccat ccataatgtt tcggatgcct tttacacttg 3232261 tatttgtatc tgccatcttc acatcaccga atgtaataaa atcggccttg ccgctgactc 3232321 catacagcgg gtcatctttt gagatgcgct gagtgatgtt tgttgttacg cctttgtctt 3232381 cataatattt ttggatttct ttttttaact tttctggcgg gatggaatct atatcttcat 3232441 atttataact aaatttccta ataacatatc tatataaact ttcatcagtt tcaagtaatt 3232501 gatcaatatt gacttgagct ccatttaccc cataaacttc atcatattct ccatcaatca 3232561 attgcaccat aacttggtta ttatttgcaa gtgaatgtcc taaggcgaat gtttttaaat 3232621 cctcagagtt acctgctgct ttctttgctt tgttagtaaa ctcctttgta gcctcatact 3232681 gactatgatc aattcctaaa aaaagaccaa aaaagttata tgaccaatcc ttattatcgg 3232741 cactaccttc tgaaataatc tgaagctgat caatatgttt tttctcatct attatatgga 3232801 ttgccgttcc atcgtaacct gattctctgg tcgaactttg tatacttgta ttctgattta 3232861 caagttcatt ggaggtgtaa atttcaattt tcatattctc aggaagatcg tggtgggttt 3232921 cctctttata aattctgcgt atatctgctt cgaaatcctt cttagctttc ttaacttcac 3232981 tcgcaatagt tgaggcaaac ttttgtttat agtcatattc taaatcaatt aaccttaact 3233041 ttacgttctc attctcaaat acatttttat ttcccatctt atttctcctt tttatctatt 3233101 aaaaaggtga tagaattaat taatttctca actttatttt tagccttttc ttcatctaag 3233161 gagcatggtt gattttcatt tttgcatcca agggtaaagg cgtattctac tcctaggtta 3233221 tcttcctctg tagacttaac atatccaaaa taactgtatg aataattata ttttctatca 3233281 atatcgtcaa agatgtcttt tttcttggca gtgtaaatat ccgttttctt tttgctgctt 3233341 tttttgtatt cgcctttata atcatttttt ccactaacaa tatctagcat tgtcttaggt 3233401 tcattcgcaa aactttcttc tttgtaatat gttacatggc catcaaacat tacattggtg 3233461 tctttatcat aactattaaa tccaatactt tctttgtttt tcccggttaa cgatgatctt 3233521 cttgatagat actttccatc ctccggaaac aacatcctaa accctttcag cttagattcc 3233581 agcaaataat atcctggttc ctcttctttt gttgacacca tgtactctct cgttttctcg 3233641 tcctgaaacg caggtacttg aggcagatcc ttgggatcca tgtcttttgg ttttaccgct 3233701 tctgttttat tgtcatttgt gctgttttta tcattgtcat tcatactgca tcctcctgtc 3233761 agggcaagta ataagctgaa gcaaataaag atgatctttt tcattacgaa cctccacggg 3233821 ttttgtgaga atagtattct atttttatat caaaaataat tctattgacc tggttaagag 3233881 atgattattt catccttttt catgttacat catggcggaa tttggataaa taggaaatga 3233941 gactcggttt tgatctcctt ttattaacta atcatatata acacccaata taaatctaaa 3234001 tacctattac ttttttcaca aaacaaaaag agccgtatca tccggctctt tactcttcaa 3234061 tctcagaatg gcgttttttc aatacgtcaa gcacatcatc cagcggcagg gattgttctc 3234121 tgagcaggac aagcaggtga tacagcaggt ctgccgcttc ccatttgagt tcctcatgat 3234181 cccggttttt cgcggcgatg atgacttcgg atgcttcttc tccgactttt ttcaaaatct 3234241 tatcgacgcc ttcacggaag aggtacgtgg tgtaagctcc ttcaggcatt tccgcttggc 3234301 gttccgcgat cacccgctcc agttcgttca tgatgccgaa tcggtccgcg gcctgttctt 3234361 ctgtttgttc ctttgtaaaa cagctgtagc tgccagtgtg gcatgccggg cctgacggtt 3234421 ctacgagtac gagcagcgcg tcttgatcgc agtcataccg gatacctttg acggcttgcg 3234481 tgttccctga ggtttctcct ttatgccata acgcttggcg tgagcggctg taaaaccatg 3234541 tttccttcgt ttccagcgtt ttttcgtacg attccttgtt catatacgca agtgtcagca 3234601 cttctttgct tgccgcatcc tgcacgatag caggaattaa tccgtcctcg ttaaaacgca 3234661 gttcatctgc ctgtttcatc tcacattcac cccgtactct ttcaagtatg atttcacttc 3234721 tttaatcgat gtttctttat aatgaaaaat tgaggcggcc agcgcggcgt cggcttctcc 3234781 ttttgtaaaa gcctcaagca tatgctgtgc gtttcccgcg cctcccgaag cgataacagg 3234841 gacggggaca gcttcggaaa caagctttgt cagcgtgtgg tcgaaacctt ttttctcacc 3234901 gtcggagtcc atgcttgtca gcaatatttc tcctgccccg cgtttgacgc cttcttttgc 3234961 ccacgcggtg acctcccaat ctgttttctt tctgccgccg tgcgtgtaga ccttatatgt 3235021 gtcagattct ttgtcatact tggcatcaat ggcaagtacg atgcattgag aaccgaaaaa 3235081 ctcggctcct tctgtaatca gctcagggcg gagaacagct gccgtgttca ccgacacttt 3235141 gtccgctccg gcacgcagta tcgttttcat atcgctgagc tgattgatgc cgccgccgac 3235201 tgtaaacgga atggcaagct tcgcggcaac ctgctccaca acgtcaacca tcgtctttcg 3235261 tccttcgtgc gaggcggaga tatcaagaaa aacaagttca tccgcacctt cccggtcgta 3235321 cacttcggcg agttcaactg ggtcaccggc atccttcaat tcgagaaatt gaattccttt 3235381 gacaacgcgt ccttctttga catcaaggca tgggataatc cgttttgtga tcatttgcgc 3235441 ttcacccttt caagcgcctc actcagcgta aactgattgg tatacagcgc ttttccgatg 3235501 atcgctccag agacgccgtc cgcctcattg cgggcgagag cttcgagatc cgcgacggag 3235561 ctgactccgc cggaagcgat caccgatttc cccgtttcct tagcaagctc gaccgtgctt 3235621 ttaacattgg ggcctgacag cattccatct gtcgcgatgt cagtaaaaat aaagacttcc 3235681 gcaccttcat tggctagctc tttgcccagt tcagttgcct taagggttga tgtttcaagc 3235741 catccctctg ttgaaacaaa accgtttctc gcatccagtc cgattgcaat tttctcgcca 3235801 tattgtttca gcattttttt gacaaacgga gggttagaaa ctgctgagct tcccaggatc 3235861 acccgctcga ctcctgctga taaatattca tagacgtcat tttcagaacg gatcccaccg 3235921 ccgatttcga ctttcaggtt cagcttttgc gcaatctcaa tcacatggcg gtcattcact 3235981 cttttccctt ctttggcccc gtcgagatca acgagatgga tccattcggc accctctttc 3236041 tcaaataact cagccatgtc gtacggtgaa tcgccatata tcgtttcctt attataatcc 3236101 ccttgaacaa ggcgaacaca tttgccgttt ctcatatcaa ttgccggata taatgtaaaa 3236161 gcactcattt tttcaccttc tgttctgctg ccattttcgt aaattgggtt aaaatagaca 3236221 ttccgaccgt gctgcttttt tccggatgaa attgggcgcc gaagacgttt ctttttccga 3236281 ctacagcagg cactcgtaca ccataatcgg cgcttgccag aagcgcgttc tcctccatcc 3236341 cgtcaatgta ataggaatga acgaagtaag cgtagccttg ttctgtttta gtcagcagcg 3236401 gagattcatt atgaaaagaa agacgattcc agcccatatg cggaaccttc agcttgtttc 3236461 ctttttcatc ttctgctttc agcctgactg cttttccttt taacagcccg agtcctgaag 3236521 cggtgccgtt ttcttcgctt tcttcaaata aaagctgcat gccgaggcag atcccgagaa 3236581 gcagccttcc ctctgagacc atatcgtgaa tcaattgatc aagcttcgtg tagcccaaat 3236641 tgtccatcgc gtctccaaat gaaccgactc ccggcaaaat gaaagcatca gcttctttca 3236701 gctcctccgg cttttcagaa acaaaatacg gcacgccgac acgttcaagc gcctttgaga 3236761 cactgtataa attccccatt ccgtaatcta tcacgccgat catttacagc atccctttcg 3236821 ttgacggtat tcctttaact cgcggatcga tcgttgtcgc ttcatcaagc gcacgtccca 3236881 gtgctttaaa aacggcttca atcatgtggt gggtatttgt tccataatga acgatgacgt 3236941 gcaggttcat tcgagcttcg agcgccagct tccacaaaaa ttcatgtaca agctccgtat 3237001 cgaaagttcc gactttagca gccgggaaat cagcgcgcat ttctaagtgc ggccggttgc 3237061 ttaaatcaat cacaacttga gcaagtgcct catccatcgg cacaaacgcc gatccgtagc 3237121 gtttgattcc ttttttatcg cccaacgctt cgagcagcgc ctgccctaag cagatgccga 3237181 tatcttcagt cgtgtggtga tcatctatat caacatcgcc ttttgcgtta atggaaagat 3237241 caaattggcc gtgtttcgtg aataaatcca acatatgtgt cataaacggc acatctgttt 3237301 taatatccgc ttgtcctccg ccgtctattg taaatgccag ctcaatatct gtttcgtttg 3237361 ttttcctgac gcgttccgct tttctcattt agaaatcctc cgttctctcg cttcaattga 3237421 tctggcatgg gcttctaacc cttccagtct ggcaaaagcc gcgatgcttt cggcatgttc 3237481 ttcaaaggct gattgactgt aagaaataat gctcgatttc ttttgaaaat cagttacgtt 3237541 taatggactt gaaaatctgg ctgttccgtt tgtcggaagc acatggttcg gtccggcaaa 3237601 ataatcaccg acaggctcag ggctgtatct gcctaagaaa attgcacccg catgtttgat 3237661 actgccaagc aaagcttccg gagactgtgt tatgatttct aaatgctctg gcgcgagtgt 3237721 attgacagtc tcaatcgctt ctaccattgt ttccgccaca tatatacaac cgtaatctct 3237781 cactgaagct tccgctattt ctcttcgcgg caaggtttcc agctgcttat tcacctcggc 3237841 tgaaaccgtc tcggccagcg ccatggaatc tgtgacaaac acacatgagc taagcttatc 3237901 gtgttccgcc tgtgacagca gatcggctgc aatttcgctc ggaatcgctg tttcatcagc 3237961 cagcacgacg atttcactcg gtccggcaat catatcgata tcgacatcgc cgaacacttc 3238021 tcgtttggca agcgcgacat aaatgttgcc cggacccgtg attttatcca ccggctcaat 3238081 ggtttctgtt ccgtatgcta acgccgcaat cgcctgagcg ccgcccattt tgtaaatgtc 3238141 ttttatgccc agctcggctg cagcaaccaa aactccagga gacagcagac cgtcttttcc 3238201 cggaggcgtg acgagaacga ttctttcaac gcccgctacg agcgccggaa tcacattcat 3238261 caaaacagat gaaggatatg cggccgttcc ccccggcaca tatacaccgg cggaatccag 3238321 cgccgtcact ttctgcccca gcattgtgcc gtcctttctg tgataaaacc aggaggattg 3238381 cagctgtctt tcgtgatatt ccctaatatt ttcgattgcc tgcctaatca cctgaagaag 3238441 acgtgaatcc agtgaggtgt atgcctcctc aaattcttct tttgtgacca gcgggctgtc 3238501 tatttcgatg cagtcaaatt tcgccgtgta gctgcgaacc gcctgatcac cgtttgcttt 3238561 aacatcttca ataatggacc ggaccgtctt tctttgctct tccgttccgg catcgatgga 3238621 acgcttgaga gaaagccgtt ccgctccgct gatggttttg atcttcattt tgccgtctct 3238681 ccttccacaa cgagagatag gcgggatgcc atttcgtcaa tcacatcgtc tttcatgcga 3238741 tagcttaccg ggttgacaat aaagcgagag gtaatgtcac aaatgtgctc cgtttcaaca 3238801 agcccatttt ctttcagcgt ctgtcctgtg gaaacaatgt ccactatccg atctgcaagc 3238861 ccaatgagcg gagccagttc aattgaaccg ttgagcttaa taatctcgac ttgttctccc 3238921 tgctctctga aataactgga agccacattc ggatactttg tcgcgattct tggcgctact 3238981 ccgctccagt ctgtattcgg aagtccggcg acagctaagt ggcatttgct gatgtttaaa 3239041 tccagtacct catacacatc gcgttcctcc tccagcatga catccttgcc cgcaattccg 3239101 acgtctgcca cgccatgctc cacatacgtg gttacgtcca tcggcttcgc taatataaac 3239161 cgaagatttt cctccggcac atcgatgatc agttttctcg aatcttcaaa ctcctcaggg 3239221 agcctgtagc ctgcctgcct cagcagccct gccgcttctt caaatatccg gccctttggc 3239281 atcgccattg tgagtaactt acccattttg ctcttccttt ctggcaccga taaaataagt 3239341 gacgtttgca aaagattttg tcatctggtc gatattttct attcccgata aatcttgaag 3239401 aaccactttg ttccctttca tgcgttcttc attcgcataa gcgatggctt gcgcccgctg 3239461 ctctttgctg aaaataacag cgtctatttc acaaggttcg tccttcatat gaagggcttc 3239521 aatcagccgg tcgatccgaa gcccgaagcc tgttgccggt gcaggtgaat caaaatggcc 3239581 cagcagcttg ttgtaacggc cgccgcttcc aatgacaaaa ccgacattct cggcgtacac 3239641 ttcaaataaa atccctgtgt aatagctcat gtggctgacc atattcagat ccaggcggac 3239701 attttccgta catccgtaat cctcaagaat gtcccacagc gccttcagct catcaaccac 3239761 gctttttcct tgcgcagaat cgacgatttc ctcggcacgt ccgcatactt ctataccgcc 3239821 ccgcagttca aggagctcaa gcagcctgct tttatcaatg gaggaaagcg ggagagactt 3239881 gacatgctct ctgtagccga cgtagttctt ttcatataag aacctccgca gcacatcagc 3239941 tcgttcaacg tttccgagca cctcaacaaa caaagcatcc gcaatgccgg catggccaat 3240001 tgcaatttta aaggatgcca gcccagcgtt ttttaatgcc ccgacgacta aagcaatgac 3240061 ctccgcatcc gcgctcgtcg tgccgtcacc gattaactcc actccgacct gctcgaactc 3240121 agccggacgt ccgccttcac gctcctgagc cctgaataca tttgccgcat agccgactct 3240181 tagcggatga ccgtgtttca gaagcttcga tgccgccacc cttgcaatcg gccccgtcat 3240241 atccgggcga agcaccaatg tcttgccgtc ctgatcaagt agcttaaaca gctgctgctc 3240301 ttcaattgct gactggacgc caacggtatc gtaaaactcc agtgtcggcg tttccataaa 3240361 ttgatatccc catttatcaa tcaaatcggt taacgatcgt ctcacctttt ttttcgtttc 3240421 gtataaaccg ggcagtgtat ctctcatgcc gtgcggtttt tcaaacataa acatcaaccc 3240481 gagcacctcc gctgttatct tatgaaggaa aattccgaat cctttagttc gctaatatga 3240541 taatatgtta gcagatgaaa gaatgaaaat caacgcttaa cttcagtaag gatattttta 3240601 gttcaaatat ccttctcctc attatgaaaa aatcatgaat aatgtattaa aggtacgtaa 3240661 tatctcaaat tctttatgtt tggcatgcta taatacaaat caaatagaga acaaggagat 3240721 aaagatgaaa acactgcgaa ctctatgtgt cctgatgatt ctttcaggcg ttattttttt 3240781 cggacttaaa atagatgcaa aagatataga tattcctttt ttgaacagcc ttaaaaaagt 3240841 ggtttctgat agcgatacag actcagctgc gaatagcaaa aaggagctga agggaagcgc 3240901 aaaaccgctg gatgtcatcc tttacaatca aatggacgca ccccggctct ataacggctg 3240961 tgaagtaaca agccttgcga tggtgctgaa ttatgcggga tacgacgtga caaaaaatac 3241021 cctggcaaat caggttgcca cagtgccttt gacatacagc agcggattaa agggtgatcc 3241081 gaatgacgga tttgtcgggg atatggcgaa tggccctggt ctcggtgtct accatcgacc 3241141 gatctatcag ctggcgaaaa cctatgcggg agacaaagtg tctgatctga ctggaaaaag 3241201 tatttccgct gtttatcagc agcttgaaaa aggcaatcca gtttgggtta ttacgacagc 3241261 caactttacg ccagttgaca acatgcagac atggaaaacg ccaaacggaa cgatagaaat 3241321 tacgtacagc gaacacagcg tcgccgttac gggatatgat gataaatatg tgtatctcaa 3241381 tgatccgtat ggctataaaa acagaaaaac cgatagaaca agctttgaaa aagcgtggaa 3241441 acaaatgggc agccaggccg tggttattca aaagtaaaca cctgaagcct cactatgctc 3241501 tattctgagc aaatacgaca atattcatgc tttttgtatc aatcggtaag atcgattcat 3241561 tttccatttt tcacccaaaa ttgtctttac tttcaggctg tctgttttta tgattaaagc 3241621 agattcagcc ttgccccgat ctatgcgaga gaagccggtg caagtcgctg acgcttctct 3241681 tgcaaaaaat gaaagatatc cggggaggat ttatcattga aaaaaatcgt gtctatccta 3241741 tttatgttcg gtttggttat gggtttcagc cagtttcagc catcaaccgt ttttgcagct 3241801 gacaaagtgg tgcacgaaac aattatcgta ccaaaaaata caacatatga cgggaaagga 3241861 cagcggtttg tggcagggaa agaattaggt gacggaagcc agtcagaaaa ccaagaccct 3241921 gtttttcgtg tggaggatgg agcaaccctg aaaaatgtgg tgcttggtgc acctgcagct 3241981 gatggcgtgc acacttatgg aaacgttaac attcagaatg tgaaatggga agatgttggt 3242041 gaggatgcgt taacggtgaa gaaggaagga aaagtgacga tcgacggcgg ttctgctcaa 3242101 aaagcgtcag ataagatatt ccaaatcaat aaagccagta ccttcacagt gaaaaatttc 3242161 acggcggata atggcgggaa gttcattaga cagcttggtg gttcaacctt ccacgttgat 3242221 gtgatcatcg acaagtgcac catcacaaac atgaaggaag cgatattccg gacggacagc 3242281 aaaacaagca cggtcagaat gacaaataca cgctactcta atgtcggtca aaaatggatt 3242341 ggtgttcagc atatttacga aaacaacaac actcaatttt aacaaaaaaa gtccgctgat 3242401 gttattcagc ggactttttc aatctttctt gcatttcttc cttcgtatag atgatcctca 3242461 tcggatttcc gccgacaaat gccccgtcag gcacatcctt atggacaagc gttccggcgg 3242521 acacaactgc gccatctcct attttcaccc cgggcagaat ggtcgtgttg gcaccaatca 3242581 tcacttcgtc cccgatcaga actttgccga tccggtattc gtgaatcaaa tactcatggg 3242641 ccagaatggt cgtattgtac ccgatgattg tatttgttcc gactgagatc ttttccggaa 3242701 acatgatatc tggcatcacc atgagggcaa aggatgtctg ttttccaacc ttcatccgca 3242761 gaaatgtgcg gtacagccag tttttcatcc ctataaacgg cgtatatctc gcaatttgaa 3242821 tgacaatgaa atttttgacg acctttaaaa aaggtaccgt ttgatagaca tgccacagtg 3242881 agttggcccc cgagaccgga tgacgatctg tttttctcac agattacttc actccaacga 3242941 tttgtaatag atcactcatt ttctcaagca taaaatccgg ctcatgcttc gccagcattt 3243001 ccggcccttt aatcgtccat gcgactcctg ccgtttttgt accggcgttt ttccctgcca 3243061 gcacatcatg gtaattatca ccgaccataa tggcttccgc cggctcgctt cctagctgtt 3243121 tcagcgctaa cagcacaggc tcgggatcag gctttgcatt cgtcacatca tcaagggtga 3243181 caactgtttc aaagaattcg ccgattcccg tgagcttgag gcccatattg acagtatctc 3243241 ttaattttgt tgtcacaatt cctaatgtaa agccggcttt ttttaatgca tccagggtct 3243301 catataccgt ttcatattca gtgacgagtg aatcatgcat gtcatgattg tacgctctgt 3243361 acatagcgat catatcctcg catttatcag ggtccatcga agagaacgta tcaaaaagag 3243421 acggcccgat aaatgcaagg acatcttctc gtttatactt gctcggataa taatgctcca 3243481 gtgtatgcaa aaaggacgcg ataattaatt cattcgtatt aataagcgtt ccgtctaaat 3243541 caaacagaat cgtcgttact tgtttgtcac tcatattgct tcctttccaa ccgctgaggg 3243601 tttccatttt ttccacgtgt gcgcaatagc cattgtcagc agaactgctg tggtgacacg 3243661 aatcaaaaga agcggccaga ccggtatgcc aagcggaata aagacaagtg tatcttccac 3243721 gaccgcgtgg caggcaacga gaaatataaa tgccaatgtc atgtcccgct tgctcacgcc 3243781 gtcatcctcg acagctttga tcatgacacc cgctccgtag gccagaccaa tcgtcagtcc 3243841 cgtcaccatc gtcatagacg tatttttatt catgccaagc agctgcgtaa acggcgacag 3243901 ccacctggaa aaccgataaa gccagcctaa atctcttaaa aactggatga taatcatcag 3243961 cgggatcact attgccgcca gctgcaaaac accaagtccg gctttcgtta atgcttctgc 3244021 caacattcct agccagctgt ctggcgccgc gctcttcgca gcgataaaac cgtactgcgc 3244081 cgtttccttt ccgccatgcc aaatgaggtt gatgacgatg gctgacacag cggccaaacc 3244141 gatgcgcacg gccaatatga cgccaattct gataccaacc tttgcggcaa ctgtcgattc 3244201 gataatcaag ttatgacaga aagaaagcat aacagctaaa ataaagactt ctttcacaga 3244261 taaatccaat gttaaaatcc cggcaattcc cgcatacaga ttcagcatat ttcccagtac 3244321 aagcggaatg gccgcttcac cagaaagccc gaagagaccc attaccggtg tgatcagccg 3244381 tacaagccaa tccatgacag gggtatgctg gagcaaagtg accaatagcg ttaccgggaa 3244441 aatcacttta cccagcgtcc atgttgtttg aaaacctgct gcaagaccgg ccagaaagat 3244501 cttcttcatc cctcatcccc ctttgttgac gtctactccg cgtaccgctc cttcgagtat 3244561 cccttgacgc gtctgaagat gatggctgcc acagccaaaa caatcaatac gattgaaatc 3244621 acctgagcga tgcgaagtga atcagtcagc attaagctgt cagtccgcat tccttcaata 3244681 aagtatcttc cgattgaata ccaaatgata tagatcaaga acatctcgcc tctacgcaaa 3244741 ttcgctctgc gcagcagcag taaaacaatg acgccgacaa agctccatag tgattcatat 3244801 aaaaaagtag gatgataata ttgcccattg atatacattt gattgatgat aaattcaggc 3244861 aggtgcaggt tttctaaaaa ggctctgctg acagcctcgc cgtgcgcttc ctgattcatg 3244921 aagttccccc agcggccgat cgcctggccg agcaaaatgc tgggcgcggc aatatccgca 3244981 agcttccaga acgaaaggtt tttcactctc gaaaacacat aacccgttaa aatggcgccg 3245041 attaatccgc catgaatggc aatgccgccc ttccaaatct taatgatttc tcccggatgt 3245101 gccgcataat agtcccattc aaaggcaaca taataaattc gtgcgcaaat aatcgcaatt 3245161 ggaatggcaa acaggacaag atcaataaac gtatctttct gcagcccccg tttttcactt 3245221 tccctcatcg ctatccacag cccgagcaaa gcgccgagac cgataatgat tccgtaccag 3245281 tggacggcta acggccccag ctgaaatgct atcggattga gtggttctat cgcttcattc 3245341 atttaacgcc aactcctatt cttcttgttc accgtcttca atgacgtccg ccagcttgtt 3245401 ggtaaattgt tcagcggcat tcagccccat ccgcttcaat ctgaagttca ttgctgccac 3245461 ttcgatgatg actgcaagat ttcggcctgg gcggacggga atcgtcagtt ttgtaatttc 3245521 tgtatcaatg attttcatgg tctcttcctc aagtccgagc cggtcgtatt gcttgccctg 3245581 ctcccagagt tcaagattca tgacaatcgt gattcgttta ttgcttctga ccgcgccagc 3245641 gccaaatagc gtcatcacat tgataatgcc aaggcccctg atctcaagaa ggtgctcaat 3245701 taattccgga gcgtttccca caagagtatc ctgatcctcc tgccgtattt caacgcaatc 3245761 atcggcaaca aggcgatgcc ctcttttcac aagctctagc gctgtttcgc tttttccgac 3245821 gccgcttttt cctgtgatca gcacgccgac accatatata tcgacaagaa cgccatgaat 3245881 tgctgtggta ggcgccagcc tgctctcaag gaagttggtt aaacggcttg acagtcttgt 3245941 cgttttcagc ggcgatctga ggacaggcac cccatttttc tcggaggcgt caatcagctc 3246001 ctgcgggatg ggcatatctc tagaaagaat aatagctggt gttacatcag tgcacagaga 3246061 atccattcgc tgctttttct cctcttcagg aagctgttca aagaaagaaa gctctgtttt 3246121 tccgagaagc tgcacgcgct ccctcgggta atatgtaaaa tatccggcaa tttcaatacc 3246181 tggtcttgat aggtcactca ttgtaatcgg gcggttaatt ccttcttctc cgctgattaa 3246241 ttccaaattg aactgttcca ttacgtcttt tgtgcgaacc tttgccacga tatgttcctc 3246301 ctgttccggg ctgccccgag cttgctcaca atactttcat tttatcactt tcgggcttga 3246361 acctaaaaca gattttataa aaggggggaa aacacctcag ctggtctaga tcactagtct 3246421 gaaaaagagt aaaataaagg tattcaaatt ccagaaaggc ggatcatcta tggcagagag 3246481 tcttcttatc aaagacattg cgatcgtgac agaaaatgaa gtaatcaaaa acggctatgt 3246541 cggaatcaat gacggaaaaa tcagcacagt ttcaacagaa cggcccaagg agccatattc 3246601 aaaagagatt caagcacctg cggattccgt tttgcttccc ggcatgattg acattcatat 3246661 ccacggcggc tatggcgcag atacaatgga tgctagcttt tccacgctcg acatcatgtc 3246721 gtcaagactg cccgaagaag gcacgacgag ctttttagcc acaacgatta cccaagagca 3246781 tgggaacatt tctcaagctt tggtgaacgc aagagagtgg aaagcggctg aagagtcctc 3246841 tttattaggt gcagaactgc tcggcattca tttagagggc ccctttgttt cgcctaaaag 3246901 agccggagcg cagccaaagg agtggattag gccttcggat gttgagcttt tcaaaaagtg 3246961 gcagcaggag gcgggcggac tgatcaaaat tgttacactt gcgccggagg aggatcagca 3247021 ttttgaactg atccgccatt tgaaagacga atcgattatc gcatccatgg ggcacacgga 3247081 tgccgattcc gcattgctgt cggatgccgc aaaagcaggg gcgagccata tgactcatct 3247141 gtacaacgcg atgagcccgt ttcatcaccg agagcccgga gtgatcggaa cggcgctggc 3247201 ccatgatggg tttgtgacag agcttatcgc cgatggcatt cactcccatc ctttagctgc 3247261 aaagcttgct tttttggcga aaggcagcag caagctcatt ttaattaccg attccatgag 3247321 ggcaaaagga ctgaaagacg gcgtatatga gttcggcggc caaagtgtga cggtaagagg 3247381 acgaacagca cttctttcag acggaaccct tgccggttcg atcctcaaaa tgaacgaagg 3247441 cgcacggcat atgcgtgagt ttacaaattg ctcttggacg gatatagcta atataacttc 3247501 tgaaaacgcg gccaaacagc tgggcatctt tgaccgaaaa ggcagtgtga ctgtgggaaa 3247561 agatgcagat ttggtgattg tcagcagtga ttgcgaggtg attctcacca tttgccgcgg 3247621 aaacattgca tttatatcca aggaggctga ccagatatga aagtaatgga atgtcaaacg 3247681 tatgaagagc taagccaaat agcagccaga ataacggcag atacaatcaa agaaaaacct 3247741 gatgctgttc tcggtttagc gacgggcggc acaccggaag gcacgtatcg ccagctgatc 3247801 cgcctgcacc aaactgagaa tctctcattt caaaacatca ctacagttaa tttggatgag 3247861 tacgccggac tttcaagcga tgacccgaac agctatcact tctatatgaa cgaccgtttt 3247921 tttcagcata tcgacagcaa gcctagccgg cattttattc cgaatggaaa tgcagacgat 3247981 ttggaggccg aatgcagacg gtatgaacag ctagtcgatt ccctcggcga cactgacatt 3248041 cagcttctcg gcatcggccg aaacggacac atcggcttta acgaaccggg aacgtctttc 3248101 aagtcgcgaa ctcatgttgt gacattaaat gagcaaaccc gccaagcgaa tgccagatat 3248161 tttccctcca tagacagcgt gccgaaaaaa gcactgacaa tgggaattca aacgatactc 3248221 tcaagcaagc gcattctgct gcttatttct ggaaaaagca aagcggaagc tgttcgtaag 3248281 ctgttagaag gaaacataag cgaagatttt cccgcatctg ctttgcacct gcattccgat 3248341 gttacggttt tgattgatcg tgaagccgcg tcattaagac cttgaaagga acatgctgac 3248401 ttatgaatat caataaacaa tcgcctattc cgatttacta tcagattatg gagcaattaa 3248461 aaacccaaat taagaacgga gagctgcagc cggatatgcc tcttccttct gagcgcgaat 3248521 atgccgaaca attcgggatc agccggatga cagttcgcca ggcgctttct aatttagtta 3248581 atgaaggctt gctctatcgc ctgaaagggc ggggcacctt tgtcagcaag ccaaaaatgg 3248641 aacaagcact tcaagggctg acaagcttta ccgaggatat gaaaagccgc gggatgacac 3248701 cgggcagcag gctcattgat tatcagctta ttgattcaac tgaggagctc gcggctatat 3248761 taggctgcgg gcacccctcc tctatccata aaatcactcg ggtgcggctg gcaaatgata 3248821 ttccgatggc gattgagtcc tcacatattc cgtttgagct tgcgggtgaa ttgaacgaat 3248881 cgcattttca gtcgtcgatc tatgatcata ttgaaaggta caacagcata ccgatttccc 3248941 gtgcaaaaca ggagcttgag ccaagcgctg ccaccacgga agaagcgaat attcttggta 3249001 ttcaaaaggg agcgcctgtc ctattaatta aacgaacaac atatctgcag aacggaactg 3249061 cttttgagca tgcaaaatcc gtatacagag gcgaccgtta tacatttgtc cactatatgg 3249121 atcgtctttc ataaaaaaag cctccaaccc tttttaagga ttggagacat ggcgaaaatc 3249181 aaactggtct ggtgccggac gatatgtttc ttttttcgtc ttgaacttcc agatcggtga 3249241 tttcgttttg ccgttaaaac tgtcttccac tataatgtac caataataaa cagactgcgg 3249301 ttcaagatga tcccagcgga attcagctgt gtccccgctc ttcacttgct cccgttttcc 3249361 gagctcttca ttggtatata cgttacattc aaaataatcg gtttccacct ttttgattct 3249421 tggcttcaaa tcaagcgaaa gggaaaattc atccttgttg ccataggtat ccgtatcata 3249481 gtagttctta tcctttacat acggagagta cgtcgatacg tgcaccatgt cattggcttg 3249541 gtcaaattga agcaaacgca aatacccttg gccgccttct ggcccgccct gataatcggc 3249601 cagcatttga tgcacaagac gatccggttt cccatcacca tcatcatcca gctcatctgt 3249661 ttttctcatc gcactatgat aatgcccgct caacaccatc acgacattcg ggttcggctt 3249721 tacgatttct ttgaatattt tctctccgat tgggcttctg tttccgctga ccagcaaata 3249781 ctcatgaaaa gctaaaatgg ccatccggtc aggatgcttc ttcagcacct gattcatcca 3249841 cgcgatgtct tcatccgtaa tgccccatcc catgtacagc atgatataat cattgccgtt 3249901 gctagaaatc aggtcataat gtccgcggtt atttttatag gaaccgccat aatgaaattt 3249961 tttatcaaaa cgatcgctgc caaaatattt gccaaacgcc ctgtaggagc cgtccttatg 3250021 tccgacatcg tgattgccgg ccagcacgcc gtaaggaatt ccgctcttat ccagaacgga 3250081 cattgaccga tcagcgtttt tccactgtct gatatcggcg gaatcatcta caatatcacc 3250141 cgtgtggaac acatatttga tattgagctg cttttgatta tcttttatcc attcggtctg 3250201 tttatcaaaa atatgcggat agctttcggc gtaatactgt gtatcagaca tccagacaaa 3250261 tgtgtacata tccttcgcag gaggaatttc atcctgtaca atcacattca ttttcgactc 3250321 ccgtacaaaa tcggcggcaa tcacagacgc tttcagcgta aacggtttgt catccttcgc 3250381 gacgaagctg tcaacaggct gccattcgtt tgtccgataa ttccaagcat acatcgtcac 3250441 ctttctcccc ggcaaagaac tgcccttcca gactgattct gccagatcat tctcatcaat 3250501 tgatggatca accgtcactt caaagcgatg ataagggaaa agctctttgt tttctgtcga 3250561 tactgttttt ccatcagcag ctgatacccg ctccaattct ttattcgtaa atggggtctc 3250621 cctttccggc acaaagcttt tcggcggttc agtcagtgac gcgtgcttaa atattttcac 3250681 atgattgcgc gctgtatatt gaaatcccct ataaaaacca acatccatgg catcattcgt 3250741 cggatctttc acccgtacag aaagcttggc cttatgcgtg tcggcttcgc tgtctataac 3250801 ctccggctgg tccggatgct ctcgttcggt tttaaatatc ctctcaatca ctgttttatt 3250861 gcccgcgaga tccgttgctg tcacttttag agaatgtttt cccggcaaaa ggtcagaaga 3250921 tgacgtatga tatgggagtg taatgctttc tccatctaac gacgcctccg cttcctcaat 3250981 tctgctccat ttatcataca tatccgcctg caggataagg tttcctttat acgtttgccc 3251041 ctcggtgata ttcggctcaa tgtgaggtcc tgaattatct acccgtacaa ccaggctgac 3251101 attttccttc ccgtcgcttg cttgaatatg gtgagcgcct tcagaaagct ttgatgtatc 3251161 ccactccagc agctgtgatg taaatagtcc gtcaggcaga ttgaactgaa attgccagct 3251221 tttattcgag cgctgattat cgccaataaa gagttccttc tcaggagaca ccctctgatc 3251281 tctgatcacc gttccatccg ataacaccaa tcgggcgttt ttgactaaga agtcatcacg 3251341 gttttcagcc gtatcaaacg gagacacctt cgaacctgaa cgtatcgtaa tacgctgcag 3251401 ctgcttccct ttccgaagca gtgtctctgg caatggaaca gaataggtgc ggtatttatt 3251461 tgttgtatca tcgaacacct tcagcacttt gccttccatc gttaccgcgt ttttaaaata 3251521 aaggttcgtt ttcctcgtat cgaatgcaaa atatacttct ttttccatcg cgggctctgt 3251581 cacttgtttt ttcccgtcaa tccatagctt aatgctgtca gctcgccctt ctgtcgtggc 3251641 tttgagaaat tgagttcccg acagcgtgtc tctgttttca atattcatcc gcagaccgtg 3251701 cgccttgctt gtttgtttaa tatcaatcat tttgaccggc gttctcgctt cattgatccc 3251761 gtccccggcc gccacataat actctagctg atccttcccg atcaattcag gcgaatacac 3251821 aatataatgg aagagattat cgttgcggtc tttttcagca agaattcgct taaacggttt 3251881 gttctcatcc gtccggtagt aaaaggccac tgttttcact aggcttcggt cccgtatgtc 3251941 agcccgcagc tcaatgcttt cagcagggcg gacaggcttg cggtcagtca aatcctcaat 3252001 gaccggcttt tctttatcga gcttgatttt ccgtttctgg tcgggcacct gtgcctgtaa 3252061 tacggttccg ggagacggat tcttttcccc gattgaaatg ttcagaagtt ctgctgttcc 3252121 gttcagtgga tacttataaa gcactgatga cagccggcgc agcgcatgtt tccgataatg 3252181 cgcaaccgaa atgtcctttc ctgtattcgt tgatatcaca acggcccgcg gcctcgtatt 3252241 ggccataccc tctgtctcgt ctatcaccgc aagatttttt ccttctttta gttgtgtctg 3252301 ataataacga ttgaaatccg ctgacgtcaa ttctggatgc ccggcaggct tcagccagac 3252361 gacaaacgtt tcgccggatg gtatcaagat cctttcatca ggtctccaaa tcagatcgga 3252421 gtcaggccct tcttttgggt agcggtaacg gatatggtag tctttaaaat caatcgttct 3252481 gtcagtcgta ttaaaaatct caataaattc ataaccgtct gcgcgtccta tattcttcgt 3252541 atcaaccgcc agctctgtga tcagaagctc cggaatatgg gcaaggtcag cctggtatcc 3252601 ttcaagcttc agtttcttcg tctccgactc aacccgctgc ttcccattcg acatcacaat 3252661 gtaatactca agctcgctgt tccaaatcaa acgtttcgga atttgtgcca aaaacttgcg 3252721 gaccgctccg ggggtcgggt ccatcggcac cattttgtag cccagctcat tactttgttt 3252781 ataaaaaaga aaggcggaaa atgcttgata cgaattatcg cgaacttgag cctcaatcat 3252841 tagattgctt ctcatttcag ctttcacatc aatttgagga ggattttcaa gcaagggtat 3252901 gtaatgaggc gtttgaaata gttcctgctg tacaacagga aaagctttcg attcatgatg 3252961 gccgccagac aaaacggaaa gaaaagacag taatatagaa gcaataaccg tgtatttcct 3253021 catcaaagca cctccctttt catgtatttt gcgtctgaac agggaagctt atgagttcat 3253081 ttttgtgcat aaagaacaaa aaaacgtctg tctcttgaaa attccactat tacccagtaa 3253141 actaaggata gttaaccagt taacaattaa atcagagagg caaattgatg gacaacagca 3253201 ttcatgatga attatttcaa gctatacaac aattcgcatt aaaaagggat aaacgcgtct 3253261 ggcaaaaggt gcagatacca tccattggca tatcctcaca acatcacgat cacctcaaaa 3253321 aagactggac tttgacccag cttcacattg tttcctgcat acataccagc caaaatgtga 3253381 acaacagctt cttagcatcc cgtttacaca tctcaaaagc cgctgtttca aaagcggttc 3253441 atgctttgtt gaaacacaat atcattacag tgacaaaaaa gcctggcaac aaaaaagaaa 3253501 ttttttatac gctaactgat agcggcagaa aattggcggc attacatgaa cagcttcatg 3253561 agaaagcaaa ggagcaatat aaacagcttt tcaatgaatt ttcaattgat gatttaaaaa 3253621 cagtgactgc gtttttcaac ttgtggatca aatatatgta aaaagagtct cacccgcatg 3253681 ggagagacct ttggaattct attatgcccc gtcaaacgca acgagaagtg aaacaggtcc 3253741 gcgtgtatac agaccggact cagcataaca aaaatcttcc tctaatctga tattccgcat 3253801 cttatccagc acaatattag ctacaatttc gatttcgttt ttggcaaaag ctgctcctac 3253861 acagttatga atgccggatc cgaaagcgag atgccgggcg gcgccgctaa aagcgctctt 3253921 gataccaaga tcttcccgat gaatattaaa cacgtcaggc tgttcaaatg cttcagggtc 3253981 ccggttagcc gcaccgatca tacaaaaaac aatcgtatct tttttgattt ccataccgcc 3254041 gaccactgta tcttgggaca gctgccgcgg aatcagctga accggcggtt tataacgcaa 3254101 tgtctccgca atggctctcg gaactaacga acggtcagcc aaaacatcat tcatctgctc 3254161 aggattgttg agcaaatggt agatcatcag tgccagcgtc ttatcagccg gttccgttgc 3254221 ggctaacagc acattaagaa tcagtgcgag tatatccttg tccgacagcg ccatgccttc 3254281 atattcagaa gtacatagga tcgaaattaa atctgatccc ggattgacgc gacgttcttt 3254341 aatgaccggc atcaagtatt gggaaagctg ttcgctgcac cataacgaat gtgcccgcgc 3254401 ttcaggagat tgagagatac tcgtgataaa atcggcaact ccgctgtgcc actcagagat 3254461 tttttcatgg tctcttttat ccagcccgag catgtccatc gtgacgcaca ccgcaaacgt 3254521 ctttccaaaa tcattgacga gatcactttt ccctctttca agataaggcg ctaacaagtt 3254581 ttctgcattt tgtttaatca atggagacag atgatccagt gcgtcaccga taaagcttct 3254641 cactacaatt cttcttttgg cagagtgttc ttttccatgc atttgggcca gcacagggcc 3254701 tcgcatgact ggttcggcac gctcaacaag tgatttcgtc gtgaagatat ccggatgctg 3254761 aaggatatag cggacatcat gatagcggct gataaaataa ctgtctatcg actcttcata 3254821 atgaaccgga tcttcctccc gcagttgtga aaaataagca tatggattgt tttgaaattg 3254881 atcagaaagc acactaaaca atttaatcga ttggctcatg ttttactccc cctatcatcc 3254941 ttcagatgtg atccgtttct cagaaagcat ctgcgccatt tcctgtacaa tgagataccc 3255001 ttgattcggc cgcatacaaa tagaaaattc atggttactg atcttctcac ccagcttcca 3255061 cggacgatga taagcaagga gtgtctcttc cacctctaaa atatccggag ctccgataaa 3255121 aaacggcagc tcagctatga catattccac agccaaattc agcatatcct cactgacttc 3255181 ttccatcatc aaactgacgc cccgcgcacg cccgattatc gcttcacgag acatgtccaa 3255241 acaagcatgt cgaaaatgag gctgctcaaa aaatgcatgt tcaacttctt gtctcaacag 3255301 ctggtaggct ttgttatcta taaaatcaga aaatgtatga atcgccttcg gatccccgcc 3255361 atgagccaca agggctcttt ctgcaaatct cctgtttcgt gatacctctt tccttacttt 3255421 tcgttcagcc tttcctctcg gagttccaag cgcttctaga agattagccg cctcatgccc 3255481 tgcaagtaaa actgaaacgc ttttaaattg agctttcgcc catccaatta atctgtaaat 3255541 ataatcctct gaaaacctgc tgttaaatgg gctgatcccc accaaaacat gcctgcgccg 3255601 ttcaaatatt tctctgcagt tttctgttaa tgcctcagca ataaaatgca cagaccttct 3255661 ttccgttacc attccggtca tctcattcac ccctaaaact tatcccgctt taagtcatca 3255721 ccctcaaata caagatggaa tagctagaac aactgaacaa gacgaatggc aggcatcact 3255781 taaagtttcc aaatgttttt taagatttta ataatcattt tcaataccca tatcatgata 3255841 aatgtttact agtaaacatt agtcatttta tcccttttcc ttccaaacgt caatatgatc 3255901 tgtgcccaaa tatttgaaaa taaatgtaaa catcacattt tccacacact ttttacacgc 3255961 atattcagca tgacatatca acaaatagtc taaacaccaa caattgacaa cgaaaacaag 3256021 aaaagataaa ataaaattgt tcaccagtaa acgatttgtt ttattgtttc atcgtaaact 3256081 attattccta agaaagaagg tagcctatgt ctgatttgac aaaacagatg atatacgaca 3256141 tatacgtgag actgctgcac cttaatgaac aaaaagcgaa cacttcactt cagcaatttt 3256201 ttaaggaggc cgcagaagag gatgtagctg aaattcccaa aaatatgaca agcattcacg 3256261 tcattgactg catcggccag catgaaccca ttaataatgc cggaattgcc agaaaaatga 3256321 acttatcgaa agcgaatgta acgaaaatca gcacaaaact gatcaaggaa gaattcatta 3256381 acagctatca gctgacagat aacaaaaaag aagtttattt taaattaacc cgtaaaggca 3256441 gacggatttt cgacttacat gagaaactgc ataaaaaaaa ggagctggct ttttaccaat 3256501 tcctcgattc attttcacaa gaagaacaaa aggctgtatt gaagtttcta gagcagttga 3256561 cgtcaacact tgaagcagaa caaaccgatg ggactccaga caaacctgta aagtaaacaa 3256621 aaaggcggtg tacactttgg ctcatacaaa atcaaaggca gtattgatct tatacactgt 3256681 ttgcttcagt gcattttttg catctttaag ccagaacatt tattcaccta ttcttccgat 3256741 cattaaagaa tcattccatg tttccacagc tatggtgaac ctgtcagtct cagtttttat 3256801 gattgtgaca gcaataatgc aaattatatt aggagcgatc attgatttta aaggcgctcg 3256861 gatcgtcttg attaccggta ttctggcaac ggcagcagcc agcatcggct gtgcggtgac 3256921 tactgacttt accttgtttc tgatattcag aatgatacag gcagccggtt ccgcagcact 3256981 gcctcttatt gctgccacaa cgatcggaca gctgtttaca ggaaatgaac gcgggagtgc 3257041 aatgggaacg tatcaaatgc tcctgtctgt cgcaccggct attgctccag ttctaggagg 3257101 attcataggc ggagcagccg gatacgaagg gattttttgg atacttgcgg ccatctctat 3257161 cgttttgctg gtgacaaaca gcatcacctt tcctaaagat tctccaactg aatctatgca 3257221 gcaagccaaa ggcaatgtgt tcgctcatta taaatcaata tttacaaatc gaacagggaa 3257281 cgtcattttg actttaagtt ttgttctctt tttcatttat tttgcagtaa ttgtctacct 3257341 cccaatattg ctgacagagc attaccatat agatgtgggt atagcaggac tgttatattt 3257401 gccgctggcg ctgagcacga ttgcaggtac gtttctgttt aaaagaatac aggcaaaaat 3257461 cgggctgcac accttgttta tcggaagcaa tgtgattgcc gcctgcagca tcattttatt 3257521 tgctgttaca cattccgttt ctctcgttct catggctctg acgctggcac tgtttggcat 3257581 ctcgatgggg gttattcctc ccttgtactc tacaatgatt actaatgaat ttgagcacaa 3257641 cagagggagt gcaatcggaa tgtttaactt tatccgatat acaggcatgg cagcaggtcc 3257701 gatggtatct gcctacttgc tcacaatgat gccgtctgcc atgtccttta gcctcctagg 3257761 ccttggattt gccgcattga gcttttgcct tcttccgcca atgttttcgc cgcagaagcg 3257821 cacgaaacaa aaaaagcacc acatgtaaaa aagctgcctt tgcgggcagc tttttttatt 3257881 tttttctaag cggctctaaa atgccttttt gaatcagcaa atggaagacc gacaggataa 3257941 cggatgccca tatcgctgtg ccgaagccgt cgatttgaaa gctgtcaccc ataatggacg 3258001 cggtcatcat aagcgtgatg gcgttaatca caaacaagaa gagtccaagc gtcaccatgg 3258061 tgaccggcag tgtaaatata attaaaagcg gtttaatcag cacgtttaag atcgataaaa 3258121 tgaggctggc gataatcgct gccccaatgc tgctgatatg gatggagtca atatatccat 3258181 caatgacgat taataacaat gcattgacta aaatgctgac tgcccatttt accatgtcat 3258241 ttcatatccc tttctgacgg gacgataaaa atccaaatga tataaatgag caaaaccggc 3258301 aagacacttg tcataatggc taagatgaca gttatgactc tgaggagtga tgcgtcccaa 3258361 ttgaaatatt ccgcgagacc tccgataaca ccggcgattt tcttattttt ttctgagcga 3258421 taaagcttat tcattcgatc acctctgtga gtactttagt ttgatggcgc ctgttagtga 3258481 ttctgagaag acggtgatgt tttgatcatg tgcctgattt gaagtgaaca tcatttcttt 3258541 ttgaatcgta tcattttttt ccttcagcat ctctacatcc attaattcat gggacagcgt 3258601 accaagattg cttttcagct ctgccttcac tgcgagatcg tccggaattg caagctctac 3258661 atttccagtc gttgtttttg cataaatgga gcggcagtct gattctgtta cgttaatcgc 3258721 aatatttccg ttaaagcttt gaacgtcaat ggattcgctt ttccctcgga gatcgatcaa 3258781 tccgttaatg gtttccgctt ctatcgtacc gcagctgtgg cttgcgagct taatttgccc 3258841 gttggccgtt tcagctatgg ctttttcggc tgttaaatac gagaacgaca gcacgccgtt 3258901 tgtcgttttc gctgagaact cttttacatg taaatgttcc cctctgactg gaccgttaaa 3258961 cagcttcacc cgaatcttat catactcctt ctgaggaata tacaaagtga cattcgtttt 3259021 catcgtcttt ttctcagtac ggataaaaaa cttattacct ttgatttcac attcaatatg 3259081 ctgaagaaat gcgtgtctcg ccgcatcctg gctgtcagcg cgatatacct tcgcctggca 3259141 ttccgctctg atatcgtcat cttcccaagg gacgatattt acgctgccat tggcaatttg 3259201 cagctcaaca ctggaaaagt cagtatcttt aaattgaaaa atgtgctgaa catcatacgc 3259261 atggccaaag tttaaatcaa ggtcaacttc cttgaccttt ttcacagcag aatcaatcca 3259321 gtcaaacagc ttggctccta aagacggttt gccgctttct ttttttgccg ttgtaaatgg 3259381 ctcttcctcg tcatgaacgt gaactgagag cgctgtgatt ttctcttctt tttccttgta 3259441 gtcgctgtca agcttttcaa tcagtgtcaa agcttcttgt gctgtaagct ttccttcctc 3259501 aacaagctta aggattcgtt ccttttcttg cttcattacg atctcctccc cattgtctac 3259561 ttatgctgca cgcaggacct taatgccctg aatcacattc caaatgataa tgccaatgac 3259621 aactaagaaa taaataaccg ctcccccgat gattacaaat acaggaagca agctgtctcc 3259681 atcaatcgca acggctccgc caagtaaagc aataaaaagg aacagccagc cgacaaacgg 3259741 aacaatgtga gaaataagag agcgtatcgc atggcgtttt gtttctttct catttacaac 3259801 aaaatatgcg acaatcggca caatgattgg cgcaatgaac acactgaaat aacaaagtga 3259861 tgcaataata gcttgattac ggttcaattc attccacact cctattgtga attgtccatg 3259921 acaaaagatc agggacgttt tacttattta tacgtttaaa atctcttcag gtttcaaatt 3259981 cattctttag acatgctccg atttacggaa attggatttt aaaaagtttt agaagtagaa 3260041 tcttccggct ataccgatta caatatgtaa aaagcttacg gcaaccaagg aggctggaca 3260101 agcaatggag aaagatccca gtgactatac agtaacacaa gaatcagtgt taaagctgat 3260161 tcaggaacaa aaaagaatga atcgtgaaat gatcaccgag cttgagcaga ttcacggacc 3260221 cttcccgatc tctcacgata tccaatatat aaaagtgctg ctcgacagca gcaacacaca 3260281 tattgttcaa gatttaatga gtgtaagtaa gcagctgtat aagaagactt tgtaattgcg 3260341 gaaaacatat cattcattat aactgaaaca aagctaaagg ttagatgaca atatcttgcc 3260401 ttttttgttt tgaaaaaaca agtgattccc tggctgtcac aaaatgattg taacaaaaaa 3260461 agcctgccgg cacatccagt taatggactc tgtcggcaag ctgtaactat cagaaagaga 3260521 tagccgttca aaattaacgt aacaattgaa gcacgttttg cggctgttgg tttgcttgag 3260581 caagcatcgc ttgagaagct tgagaaggaa tgttgttctt tgtgaactcg ctcatttctt 3260641 tcgccatgtc aacgtcacgg atacgggact cagcagctgt caggttttca gaagaagcac 3260701 caaggttgtt gattgtgtgc tctagacggt tttgtaccgc accaagttta gcacgttggt 3260761 ttgagacatt gttgattgca gtatcaatac tttcaagttg tgtatcaaaa ggagtattag 3260821 caaaatctgt tacattaagt gcgtttactc ctaaagcagt tgatgacatg ctgtcaatgt 3260881 taactgtaag ctgctggcca gcatttgctc caatttggaa agtgaaacca tcagtttcag 3260941 taccatctaa taactttttg ccgttgaatt cagtacgatt tgaaatgcca tcaacttcct 3261001 caataagcgc atccatttca tctttaattg caccaagatc ttctgcttgt tgtgtacctg 3261061 tgtttcctgc ttgaacagta agttcacttc taaacctatt atgccgtaaa gaaaaagctt 3261121 gcctgctaag cccaaggatg gacttgccga caagctgtcc cctcttaaca gagggtttta 3261181 agatgtagct gtttcttttg ctttcaagag cgatttcatg cgtgttttgt cacgttcgat 3261241 aacaggcttt aaataacggc ctgtatacga ttcttcaact tcagtgattt cctcaggcgt 3261301 tccagacgcg acaatggttc cgcctccggc tccgccttcc gggcccaaat ccacaatgta 3261361 atcggccgtc ttaatgatat caagattgtg ctcaataacc agtacagtgt ctccgttgtc 3261421 taccaaccgt tgcagcacga caagaagcct ggcgatatcg tcgacatgca aacctgtcgt 3261481 cggctcatct aaaatgtaga gcgtacgtcc ggttgagcgt ttgtgcagct ctgacgcgag 3261541 cttcacgcgc tgcgcttctc cgcctgacaa ggtcgtcgcc ggctggccga gcgtaatata 3261601 acctaaacca acatcataaa gggtttggag cttgcgtttg attttcggga tattttcaaa 3261661 gaaagaaaga gcatcttcaa ccgtcatatc aagcacatca gagatgcttt ttcctttgta 3261721 cgtcacttca agcgtttcac ggttatagcg tttgccgtga cacacctcgc atggaacgta 3261781 tacgtcagga aggaagtgca tttcaatttt aataatcccg tctccgcggc aggcttcaca 3261841 tcgtccgccc ttcacgttga agctgaaacg gcctttttta tagccgcgga ccttcgcttc 3261901 atttgtctgc gcgaatacat cacgaatgtc atcaaataca ccggtgtatg tcgcagggtt 3261961 ggatctcggc gttcttccga ttggcgcctg gtcaatgtca atgactttat ctaaatgatc 3262021 caaaccttta atctctttat ggctgccggg cttcgctttc gctttatgaa gcttttgcgc 3262081 cagcgcctta tgcaaaattt cattaacgag tgtactcttt cctgaaccgg aaacacctgt 3262141 aactgctgta aacgtcccaa gcgggaactt ggcattcact tttttcaggt tgttttctga 3262201 tgcaccttta atttcaatgt aacgtccgtc cggctttctt ctttcaggag gcaatgggat 3262261 aaactttttc cctgataaat agctgcccgt taatgaattt ggatcttcca tcacttcttc 3262321 cggcgtaccc gcagatatca cctgtccgcc gtgaatgccg gctcccggtc caatatctat 3262381 taaataatct gctgccatca tcgtgtcctc atcatgttcg acaacaatca gcgtgttccc 3262441 gaggtctctc atatttttca gagcgctgat caagcggtcg ttatcacgct gatgcagacc 3262501 gatagacggc tcatctaaaa tataaagcac accggataaa cgcgagccaa tttgagtcgc 3262561 cagcctgatg cgctgcgcct ctcctccgga caatgtaccc gctgccctgc tcaatgtcag 3262621 gtaatcgagg ccgactttgt ccagaaagct taagcgctcc acaatttcgc gcaaaatcaa 3262681 attggcgatc tgcatatcct tctcagaaag ggtaagatct ttaaagaagg caagtgcgtc 3262741 ggcgacagac agctcggtaa ttttcccaat gtggcggccg tcaatcagta cggcaagcgc 3262801 ctctttcttt aaccgatagc ctttgcacgt cggacaagac ttctgagaca tatactgctc 3262861 catttgctca cgtatgaaat cggagcctgt ctccttatag cgtctttcaa tgttgcgcaa 3262921 tacgccttca aattgaattt caccttcgcg gatttgtcca aaatcatttt catatcggaa 3262981 ataaatcagg tcatccccgc tgccgtacag cactttatcc agttgatgct tcggcaaatc 3263041 tttgaccggc acatccatat caatcccgta gtgggtgcag actgcctcaa gcagctgagg 3263101 ataatattgt gagctgatcg gtgtccaagg ggcgaccgca ttctccttca atgacaaatc 3263161 ttgattgggg atgacaagat cggcatccac ttcaagcttc attccgagac cgtcacacgt 3263221 cggacacgcc ccgaacggac tgttaaacga aaacagacgc ggctcaagct caccaattga 3263281 aaatccgcag tgcggacagg catgatgctc gctgaacatc agctcttcct caccgatgac 3263341 atcgatcata acccgtcctt cacctaaacg aagcgccgtt tccaatgaat ctgacagccg 3263401 ggctgccacg ccttctttca cgacaatccg gtcaatgact acctcaatgg aatgcttctt 3263461 gttcttttct aattcgatat cgtcggaaag ctcagccatc tcgccgtcaa ttctgactct 3263521 gacatagcct tgtttcctaa tctgttcaag cactttgaca tgagcgcctt ttcggcccga 3263581 gacaatcggc gccagcacct gaagcttcgt ccgttccggg tattccagaa ttctgtccac 3263641 catttgctcg atggtctggg atgtaatctc aattccgtgt tccggacaat gaggcttccc 3263701 tactctcgca tataaaagac gcagataatc ataaatctca gttaccgtac cgacagtaga 3263761 cctcggattg cggctcgttg ttttctgatc aatgctgatg gcgggagaga gcccctcaat 3263821 tgcatccaca tccggcttat ccatttgccc taaaaactgg cgggcatagg cagacagcga 3263881 ctcgacatac cgtctctgtc cttcagcata tatcgtgtca aaggcaaggg aggatttacc 3263941 tgatccggac aaacccgtga caacgacaag ctgatctctc ggaatcgtta catctatatt 3264001 tttcaggtta tgcgccctgg ctcccttcac ctctatccga tccatagcca tttgttcatc 3264061 atccttccgc ttttagctct aaaagtaaat cgcgaagctc cgcggctctc tcaaagtcaa 3264121 gcgccttggc ggcttccttc atttcatgct ccatctgttc aacgactttc tggcgttctt 3264181 tcttcgtcat tttcgacagc ttcggcgcgg cttttgtttt gtattccgct ttatcctcag 3264241 ctgctactgt ggcacgaatg acatcgcgaa tttctttatt tatcgttttc ggcgtaatgc 3264301 cgtgctcttc gttaaaccgc tcctgctgct cgcggcggcg ttttgtttca ttaatcgcaa 3264361 tttccataga cttcgttatt ttatcggcgt acataatgac gcggccttcc gcatttctcg 3264421 ctgcccgtcc gatggtctgg atcagcgacc gctccgaacg aaggaaacct tccttatccg 3264481 catccaaaat cgcaacaagg gatacttcgg gaatgtccaa accttccctc agcaggttga 3264541 tgccgacaag cacatcgtac ttgccaaggc gcaggtcgcg gataatttca atccgttcaa 3264601 gcgtcttgat ctcagaatgc agatagttta ctttaatgcc gatttccttt aaataatcgg 3264661 tcagatcctc tgacatcttc ttcgtcaaag ttgtcacaag cacccgttca ttccgctcga 3264721 ttcttgcttg aatttcgccg atcaagtcgt caatctgacc ttcgattgga cggacgtcaa 3264781 taagcgggtc aagaagcccc gtcggacgaa tgatctgttc gaccatttca tctgtatgtt 3264841 caatctcgta cggccctggt gttgctgata catacacgat attgtgcata tgcttttcaa 3264901 attcctcaaa acgaagcgga cggttatcaa gcgctgatgg aagccggaag ccgtgatcca 3264961 cgagcacctg tttccgcgcc tggtctccgt taaacatgcc gcgcacctga ggaattgtca 3265021 catgcgactc atccaccacg atcataaaat cgtctgggaa ataatcaaga agcgtatacg 3265081 gcgttgaacc tggaggccgc agagtcaaat gtcttgaata gttctcgatg ccggagcaga 3265141 aacccatttc acgcatcatt tcaagatcat atcttgtccg ctgctctaaa cgctgcgctt 3265201 caaggagctt tccgttttca tgcatgacct tcagctgctc ctcaagctcc ttctcgatat 3265261 tttgaatcgc cttctccatt ttctcggccc gcgttacgaa gtgggatgcc gggaaaatcg 3265321 caacatgatc tcggtcgccg agaatttctc ctgtcagcgc atctacttcc cgaatccgtt 3265381 cgatttcgtc accgaaaaat tcaactctga cacaatgctc atcacgggat gccggaaaga 3265441 tttccactac atccccgcgc acacgaaatg taccgcgctg aaagtcgata tcgttgcggg 3265501 catattggat gtctacaagt tttctgagca gctcgttgcg ctcaatttcc atttcagtcc 3265561 gcagtgacac gaccatttcc cggtattcct caggcgaacc gaggccgtat atacaagaca 3265621 cactcgcaat aataatgaca tctctgcgct caaacaaagc tgatgtggcg gagtgtctca 3265681 gtttatcaat ttcatcatta atactagcgt ctttctctat aaatgtatcc gtttgaggca 3265741 catacgcctc cggctgataa taatcatagt agctgacaaa atactcgaca gcattgttcg 3265801 gaaaaaattc cttgaactca ctgtaaagct gtccagcaag ggttttgtta tgggcaatca 3265861 cgagagtcgg cttattgact tctttaatca aattggacac cgtaaatgtt ttcccagttc 3265921 ctgttgcacc cagcagagtc tgatgcttct tgccctcctg aattcctttc acaagctttt 3265981 caatggcttt cggctgatct ccctggggct gatatttcga gactaactca aagcgatctt 3266041 tcacaaaaat aagcctccgt ttctttaacg aaatcttcct atagatatag taacacaatg 3266101 gaaagcaaaa tcactaaaaa tacgaactaa agttcggtgg ttttttattt ccagctgttt 3266161 ttgtgtataa aaaacctgct tttaaaacgt aaaagcaggt attcagtctt tatattcatt 3266221 atgtccgatt tattcttctt ttttctctgc agcttttttg gccatataca gtccgccagc 3266281 cacaagagac acaacatcca atcctacaat aaaatacgtt tctgtatagc cttttaaata 3266341 agaggcaaac agcaatgcag ctgttaaagc gatcgccaca taatgattaa aggtgactct 3266401 agtaaataga acaacaagca taaaagggaa aaacaatgca aaaacggctt ttgtaatcaa 3266461 caaaaaccct cctcagggat tcttcatctg atctgattat agtaaaaaat gaagaatcgg 3266521 acaatcgtgc attcgctccc tctacttaca ccatacccct tttcagccaa aatcaatcac 3266581 catatttgca ttttggtgcc ggtcaaaact tattccatgg tgccgctgtt ctaatcagcg 3266641 gcactttttt tattacatca tcaagtccgc cgccagattc cgagaataaa agaaaatagg 3266701 catacagtac cagtacggcc gcatttttca ggataatata accaacttaa ctattcattt 3266761 tatttaggac tttctgcgtt tgacagcatt ttcctgaaaa cctacaatta aatgatagtg 3266821 tttactatca ttttttaaac acaggctccg caataaaaag actagagaga aaaacaaaat 3266881 gaatgaagaa aagaggggtt tcaaatatgt attctgtttt atttcgccag gcagaagagt 3266941 ccagccagct ggctggagca aaaggaatga atttgattaa attgaccaaa cacggtcttc 3267001 ctgttccgga cgggtttatt attcaaacga atgcgctcgc acgttttatg gaggacaacc 3267061 agcttcaaga gactagtgaa aacgtcgaag gcgggatcat ttccggaaca ttttcggatg 3267121 agctgaaaga tgagctgact agttcctttt ataagcttag agaatcatat cgatccgtag 3267181 ccgtgcgttc ttcgtctgct tcggaagatt tagaaggcgc ctcattcgcg ggtcaatatg 3267241 aaacctactt aaatatcaaa acagaggaag agtttctggc taaagtgaaa gaatgctggg 3267301 cctcattttt ttctgggcgg gtcagcagct ataagaaaaa aatgaacaat caaatcgcag 3267361 agccgttaat gggaatagtc gttcaggggc tgatcgattc agaaatgtca ggtgttatct 3267421 tcagccgcaa ccctgttacc catgatgata gagagctttt aatcagcgcc agctacgggt 3267481 tgggtgaagc tgttgtttca ggaaatgtta ccccagacac gttcattgtt aataaatctt 3267541 cgtttgagat tcagaaagaa ataggtgcaa aggaaatcta catggagtct gcggcagaag 3267601 gaattgctga aaaagaaacg agtgaagaca tgcgcagccg tttttgcctt acagatgaac 3267661 aagtgattga attggctgaa atcacaaaaa aaaccgaaga cctgtacgga tatcctgttg 3267721 atatagaatt tggaattgct gatcatcaaa tataccttct gcaagctcgc ccgattacaa 3267781 ccattgatca ggacaaaaaa gcggcagaag aaaaacgcag cttcatgatt accgacactg 3267841 atatgaatga tttctggctt aacatggagt ctaatattga aggtccggtg agtccgttat 3267901 tttcatcctt catcgtgccg gcattggaat atggcttgaa gaagagcatg caaaagtttc 3267961 cgattggtgt agttgttgat gaagtaaaac tttatcgcgg acatatttat tccaaaaacc 3268021 aaggcggaca gcagcctcct tctgaagact gcggcaaaga gcttttcccg attttatcgg 3268081 agcatatgta tgacatcatc aatcacacat acctcccttt ttaccggaca ctggaccagc 3268141 tcgcacaaac tgagcatacc gcagaaagcg cactggaagc ttttcaaaaa ctaaaggcct 3268201 tttatctcac ggcttatgaa gagcacttta atatcgtttt cccgcaaatc cttttaacaa 3268261 acaaactgca agcgatgtat caggacattc aaggagagtc cgaaaacgct catttttacg 3268321 agatgctgac aggaaaaatg aacaaatcac tggaaacgga ccgttgctta tggctatttt 3268381 ctgtggaagt tcaggagaac ccgaaccttc tggccatttt tgaaaacaac aagcctgaac 3268441 agctccagga gaaattggaa caaacagatg agggaagaca cttcctgaag aacgtccatg 3268501 aattcttgca agaatacgga tggagatctg ttaaaagtca tgatctgatt gaacaaatct 3268561 gggtggaaaa tccgtatttc gctctggcca atattcaaaa ttatgtccgt aatggctatc 3268621 attttgacaa tgaatttcag aaaacaaaag aaaaacgaga gaaattatac aatgaattct 3268681 tggaaagcat agaagatccc ggtttacgca ccgaatttga ccgctattat caatggacac 3268741 tgaactctgc aaatataaaa gatgatcacc acttttatat tgacgccatg ctggatgcca 3268801 aggcgagaat ctttctgctg aagataggtg aattgctggc ggaaaacggt gtcattcaag 3268861 atcgggagga cctttggttc ttatatgacg acgaagtgga acaagcgctt cttcaccctg 3268921 tatccctgca agaaaaggct gaaaaacgca gacagatttt tcatgagtat gagctggccc 3268981 aagccccggc ctacctcggc accccgacaa aagaacagct caaagcagct gaagaaattg 3269041 tcggcgctgt gatagaggat gaaaaaaaca cagagaatca tatttttggc attgcggcat 3269101 caagcggcat tgcgacaggt ccggtgaaaa tcattcggga cgccaatgaa ttttctcaat 3269161 tcgcgcctgg agacgtactc gtttgcaaga tgaccacacc gctatggacc agcctgtttc 3269221 aagacgccaa agcgattatt acagacacag gcggcatttt gtctcacgct gcgattattg 3269281 cccgtgaata cggcattcca gccgttctcg gcacacgcac ggcaaccgaa agactgcgag 3269341 acggtgacat catcactgtt gacggaagca gcggcaaaat cacagttgtc agccggtcct 3269401 gatgcgtccc cctctttctt atacaagcgg ggcgggtgta tacttgtcct gccagtatat 3269461 tcgtgaggtg aaacgtattg agaccgacaa acaagagaat ccttgatgct gccatgcagc 3269521 tgctcgtcaa aaaaggatat cgcgcaacga ctacaaaaga aattgcagaa aaagcaaatg 3269581 taagtgaagc gacgattttc aggaacttta aaaacaaaca aggactagtt gaggctttgc 3269641 tttctcagca ttcttcaaac agaggcagca ttttggaaca aacagaaggg gatttgtaca 3269701 aagacctgct tcatatcgga acctgtctct tggaggagct cgaacataga aaagatatca 3269761 ttaaaatcag ctttcgtgaa ccggccatgt ttcaggatgt cattaaccac gtcactgaat 3269821 atccccaatc tatgaaacag ctattggttg attatctcaa aacgatgggt gagaaagggg 3269881 ttattcagac aggaaatgaa gcggaacatg ccgacgtgtt catgtcgatt atcttcggtt 3269941 atttcattca ccgtctccac ttaggagacc gggtcatatc aatgccccag gaaaaaatgc 3270001 tggagcatag cacagctcta tttgtcaaag gaatttctgc tgattaactc cttggcataa 3270061 taaaaaggag gatcccaatg agctcaagaa aagaatgggc gctgatcgtc tcgctattat 3270121 tgggggccat tctggttccc attaactcaa cgatgatcgc ggtcgcgctc tcatctattt 3270181 cccatacgta taacgagtcc atcgcaagca tcacttgggt ggttaccgtt tatttaatcg 3270241 tgatggcagt cacacagccg attgcaggaa agctcggtga catgtacggc aataaaacaa 3270301 tgtacttatg gggagtcggc ctttttctaa tcgcatctct aggctgcgcc ctttcaccga 3270361 gtctgctcct gttaattgtc tttcgggcat tgcaggctgt cggcggggca ttgcttacgc 3270421 caaacagcat tgccattatc cggcatgttg tttctgaaaa acgcctaccg aaagtgtttg 3270481 gatttttcgg actgggcgcg ggacttggtg cagcactcgg gccttttatc ggctctatac 3270541 tgattgacag cttcagctgg cattcgattt tttgggtcaa catcccgttc ctcgccattg 3270601 ctttatttac ggcattaacg atgtttcctc aatataaaga aaataaatct gacgcgccgc 3270661 tggatatcat cggctctctc ttgcttgcag gcagcatcgt ttccattatc ctgctgacga 3270721 aaaatgaggc tccatgggga tatactgtat acagtgtatt gatacttctt tttgttccgc 3270781 tttttttcag aagagaaaaa cgtacccagc accccatcat tgactttgca ctgtttaaaa 3270841 gctcaacctt tacaaatgcg aatctatcag tcttgttaag caatttgatg atgtatgccg 3270901 tcttattgat tatgccgtta tttatgacga accaatttgg gcttaataca tctaacagcg 3270961 ggatggcgct ttctgtattt tcgatcttca tgtcagccag caactgggtg ggcgcgcagc 3271021 tccatcacaa atggggagcc aaaaaaatca tttttctttc atttgccatg atggctggtg 3271081 cgaatctatt atttttgctg ttaagcagct cgcattctgt cttgttcctc atgctctctc 3271141 ttatccttgg cgggctcgct tccggagtcg gtctgaccag catgcaggtt tcatcccttg 3271201 ccacagtaga ccccggtatg tcaggagtgg catctgggat tttctcgacc ttccgttatt 3271261 tcggaagcat catttcatca gccttaattg gcctgatttc gggatatcac accctattta 3271321 tgattctctt tgctgtatcc atcatcggcg tttttgtttc attgggcatc aaatctgatg 3271381 aaacggcacg gatagaaaaa aactcagcgt aacacaaaac agcccggcat cgcatcatcc 3271441 tgcggtgccg ggctgccttt tatgatcccg aagcgactgc ttcgtcttca cggtcatcct 3271501 ttacgaagag gatgcccaat tcatgatgtt ctccttcata agaagctcgc tggtcaaaac 3271561 gaatttctcc attcaaaccg ataatttcaa gctttacata tgcacggtta tgctgaagcg 3271621 cttcatagaa atcagaaacg ttcttaaccg gtatgccatt gactttcgtt atgatttccc 3271681 cgattttcaa ttccagatcc tcagccggcg tattggggat aatcccaagc accattaagc 3271741 cctgatccct tttcgagaaa taaaacggag ccgcgttatc attcactctt tgctttatgg 3271801 acagaaaaat acgccctaac aaagcggtac agaccgctgc acccgcaagc ggcgtccaca 3271861 gtaagctcgc tgcaccgaga actgcgacgg caagaccgag aatacaaacg cgtttcgctg 3271921 tgatccttat actcgtttca ggcagcgatc cctgtaccct ttgtccaaat ccgacaaagt 3271981 aaggaatcca tagaaaatgg aatgagccgc cgggaaccgt aaacacgggc caccagctaa 3272041 ggtgcgattc taaaccatta ccgggcacga gaaggaacag cggcaaaagc caaacccggt 3272101 ttgccagctg ctgtccgatc ggcaaaccgc ggctgcttac gacaagtgcc ggtgatgttc 3272161 tcacatgcgc agaacgataa gcaaccgctc cttcagtgat aatcagcaaa cctagaaaca 3272221 cagccacagc cggccaaaca actgcaaatc cttgcggaaa tctctccaga aagggctccg 3272281 cctgatatat ttgcagtcca aaacctatca gcatactcac actgacgata tatgcagcag 3272341 acatccagtt tgcgcgaaga gtgaacgctg ccgctgcagt gataacggca ataatcgcaa 3272401 gtaaaccgag aggaatcgat attccgagtc cacctaaaat aactgacaaa agaagacctg 3272461 gaatcagtcc ctttgtatat gtaaatttca gatcatcata aatatctgct attcttgtat 3272521 gaaaggtttt tcgttcccgt ttgattctta catagccgaa agccaaggtt atgatgataa 3272581 aaaaccagaa aagcgggtgt aagaagaaca agcccgcgct ttttaacagt tcaattcccc 3272641 attgaacaga cactatctct caccgcctca agccaaacat gttactcata ttctatcaaa 3272701 tattaaatgg cttggatatc ctcaggagag tttatctctc ttgcgtcatc cacagcgtga 3272761 cattcgatag tgaaaaatcc tttaaatagt ggtttacatc cacatccaat aacccgctga 3272821 ttagatgcat cgaccttttt atatctgtca gattaattcc taatcgctta tggtttttca 3272881 ttaagtagtt aaaataatgt ttggcgcatt cctcattaat gtcatttact gattcgacat 3272941 tggtgtaatt gaccaaatat ctgctgaaca gcataagaag acttagtgct tttgtagctg 3273001 aaaatgttac gtcttgtgtt ctgtctttta attgttccac taattcataa tatttttttt 3273061 tcacgcacaa tacttgccct cttcaattgt gaacccccat tttctttata cagataagca 3273121 cgggccagta taagcagcag tactggagtg ctaacaagca ttctcgctaa cgttactctt 3273181 taaatacctg tcgttcagct gccattaacc tgattactgt tctttttaga accttcttat 3273241 attgtatgaa gtaaacaaag actaggcaac ttgcaaaagt ttcattttaa atgcatatta 3273301 actcgttaga aagtctctct catatattga tatcgggtaa taacagtcct ttataaatgt 3273361 ttatttgtga aaattttttt aatttcttgt caaaaactca ttttttatgt gacttatgat 3273421 ccataatctc tttaagcaca aagaaacagg agatgaaata ccatctcctt taattgacaa 3273481 ataatgattt caatgctgtt tgaagctgca aatcattttt ttcatctgat tttttctttt 3273541 ctatctgctg atttaatgtc tctgcagtgc gagtgtcgat cacaccggtt ttattcagct 3273601 tgttttgatc ctgaaaagcc ataaccgctt ttttcatgtc tttgctgaaa tagccatcct 3273661 cacgtcccgg atcaaagctg agacctttta acaatacctg cgcatgcttg acgtcttcat 3273721 tgttcatgtc cactttaagc ggctctttca gctgtaaggg cccggcggaa aaataatcgg 3273781 gctgcttaat cgcaatggtc ggttcaattc ctttcttatg aatccagttt ccatttggcg 3273841 tcagccactt gtaaagcgtt aatttgatgt tgctgccgtc ccccattggc acagcctgtt 3273901 gaaccgttcc ctttccaaaa gacgtatcgc ctacaacatc ataatggcca gcttccttta 3273961 atgcgccggc aagaatttct gatgcagagg cacttccttt atccgtaatc acattgacag 3274021 ggtacgcttt tttatgggtc aatgttgaaa aataacgttt tttatctcca ttgcgttcag 3274081 caatctgaat atacggctga tcctttgtaa cgaaatgctt aagaatttct tccacacttt 3274141 gaagatatcc acccgggttg ccgcgtacat caatgacaag tccttctatt tcttttttct 3274201 caagctccct cagcgctttt gcaaaatcct ctgcggtgtg ctcagaaaaa gtagagatgg 3274261 caatatatcc gacagaatgc ccctgtactt ttttctctga tgcaaaaacc gtttcgagcg 3274321 gaatctcagc tctcttgatc cggaatgaca actgcttctt cgttccaggc cgctgaatct 3274381 tcattgaaac gctggaccct ttttttcctc ttatttttaa cacagcgtgg tttaaatcct 3274441 tgccggccat cgattctcca ttgatgctga taatttcatc attaggcttc aacccggctt 3274501 tttccgctgg cgatttcttg aatggagaaa caataataat tttgccgtct tccattccaa 3274561 cctcagcccc gatgccttca aatgaggaat caagagaatc agaaaattgc ttagctgtct 3274621 gcttgtccat gtaaacagaa taaggatcat ttagcgtaga cagcattccc tggatggctc 3274681 cctcgagcag cttttctcta tctacttttt ctacgtactc attcgaaatt aactcatacg 3274741 ctttttcgat tttgtccata gctttatccc gttcagagtc agcttgtgcc gtcgcgggaa 3274801 ctgctgcagt ctggggctta tccatctcaa gcaggttgat tcccgcatat acaccggcgc 3274861 ctccgaacag catgctccct gctgctatca cagccattat tttttgattc atcctttact 3274921 cctcctgtat gccagactgt ctttaccaaa acctagagat agtatatgta aaggatggag 3274981 atttcatgta atcatagaag aaaaagaagg caaatgaaaa gccgtcccga aaacggaacg 3275041 gctttttcac tttatactcg cagaaacttg cggatggaag tcagacttcc ccatactcca 3275101 attactgcgc cgattgcaat cagcactagc gaaacttgga atacaaatgg attataagga 3275161 agaagagaga caaatgatcc ttgaaccttt ggaacgaccc atccgatgac gtattggtaa 3275221 gtgctcagca ccagtgcaat cggaatcaca gaaccgaata cgcctagcag caatccttca 3275281 aggaaaaacg gccagcggat aaaccagttt gtcgcgccga caagcttcat gatttcaatt 3275341 tcttttcttc ttgcgaaaat tgtaatttta atggtgttgg aaattaagaa catcgccgta 3275401 aataccaggc cgataattaa cgcgattccg atgttgcggg aaacgccgac cactttaaac 3275461 aaacggctga cctcttcttt tccataagtg actttataaa catgatccat tttttcgatc 3275521 tttttcgcca cgttcggcgt atcatgcgga tctgtcgttt tgacgacaaa cgcatcatta 3275581 agcgggtttt cctgatcctt cattgtcagg gattttccgc tgtcaccaaa actgtcaacc 3275641 agctggtcaa gctctttttc tttagatgaa aaagtgacac tctgaatgcc cttcagttcc 3275701 ttaatatcgt tctgaagctt gtcctgtgcc ttctgatctg cagtcagatc aatcagcact 3275761 ttgatttcga cttgtttttc tgcattcgtg gccatgttat tcaaattcag cataatcact 3275821 aaaaacacgc cgactaaaat cagcgtaacg gttacagcac taatggatgc aaatgtcatc 3275881 catgtgtttc tcccgagaga tttaaaactc tcacgcaagt ggcgcccgag aattttaatc 3275941 atatgaacca tactcccctc ttgactcatc acgcacaatg ataccatctt cgattgcaat 3276001 gacacgtttc ttcatggtgt ttacgatttc tttattatgt gtcgccatca cgactgttgt 3276061 cccgcggttg ttaatttcct ccagcgtctt catgacttcc caggacgtat ccggatcaag 3276121 gtttcctgtc ggttcatcag caatgacaac atcagggttg ttcacaattg atctggcaat 3276181 agatacacgc tgctgctccc cgcctgaaag ctggtcagga aattgtcgcg ctttatgctt 3276241 cagctgcacg agatcaagca cttcaagcac ccgtttctta atgacagacg gctgttctcc 3276301 aatcacttca agggcaaatg ccacattttc aaaaacagta agtttcggaa gaagcttgaa 3276361 atcctgaaag acaacaccta ttttgcggcg cacgaaagga atctcttttt ctttaattgt 3276421 cgcgagatct ttatgattga ttaaaatttg tccttttgtc ggtttttctt ctctgtaaat 3276481 cattttaata aaagtagatt tacctgctcc gctcggacca acaacataca caaactcgcc 3276541 gggatgaatg gtaacagaaa tcccattgag tgcttttacg ccgttcggat aggctttata 3276601 tacttccttc atctctatca tgaaatcacc taatctttta tatcatttta tctatcacac 3276661 ggtcatactc ttcgaatgca ttcgacaatt tatgacccat tcatttgtaa aaagatgaaa 3276721 aatctgaaag ttcccttttt caatacactt cattatacgt caaatttaga cataatacta 3276781 ttacagtttc ttttcattca tattgtcaag gcataaaaac atccttgcca gcactcggca 3276841 aggatgtttt tatcttactt tttttctgac agccatttgg caataacagc ggcttcgtta 3276901 tcatctacaa gcccctttgg catattgccg cggccgtttt taataatgct ttcaattttg 3276961 tgttcatcgt atttgcctcc gacctcttgg agattaggcc ctgacacacc ttctaaatcc 3277021 ttgccgtggc agcctacgca gctttgctga tataattctt ccccttcaga tgcagtggct 3277081 tccgtcttgc tgccagtgtc tgtcttctct tcttttgcat cgtttgatcc gcaggcagcc 3277141 aacagaacag aaagcgcaaa tccaatcatt agtatcgata actttgattt catgttgaga 3277201 agcacaactc ctttacgatc tcttccatat tataacctcg tttaagcgcg tttgaaaccc 3277261 tcgcccagca cctcgctcgc gtctgctaca attacaaaag ctgactcatc aatctgtttg 3277321 acgatttgtt tcaatttggt gaattcagtt tgcccaacca cgcacattaa aatcggacgg 3277381 tcatcgtcag tatatccgcc gactgcagaa atttttgtca cgcctctgtc aatcttctgt 3277441 aagacagcct ccttgacagc ctgctcctgc tttgtaatga tgagcgccat ttttgaacga 3277501 ttaaagccga cttgcacaac atcaatggtt ttgctggaca catagacgcc aagcatggca 3277561 tataagcctt gctcaatatt aaatacaatc atagccgtaa caacgatcat tccgtcaatg 3277621 atggcgagac acttccccaa tgacagaccg gagtacttat gaatgatctg tgcagccaag 3277681 gctgtacctc ccgtcgaacc tttccctaag tacacaatac caattccgat acctatcccg 3277741 acaccgccaa aaatcgccgc caggagttca tgatgagtgg cgggctgaat atcccttgtc 3277801 agaaacacta ctagcggcaa aaacacagaa cctgcaagcg tctttagtcc aaatttcccg 3277861 ccgagcaaaa tgacgccagc aataaataaa gggatattaa taatccactg tacatacgct 3277921 gcttcaaaac catatgattg taaaatcgta ctgatcccgc tgaccccgcc ggcggcaatc 3277981 ttattcggaa gcaaaaatac attaaaggac acggccgtaa tcgctgctcc tatcaatatg 3278041 tatacataat cccgcaaaat ccacaatgtt ttattccgta cgtccatcat atatcctccg 3278101 tttcttccaa tgctctccga tagcatttta atccttccct gattagatgt aaataacacc 3278161 caaatacagt ggtaatatgc taaagcagca gtgaaatcaa ggatataaga aataaaaaaa 3278221 cacacccgta tgcatcaggt gtgtttttca gcttatgaaa gcttagaacg caggtaggca 3278281 tcaataaacg tatcaatgtc accatccatt acagcttgaa cgttccccat ttctgtattg 3278341 gtccgatggt cttttaccat ggaatacgga tggaatacat aagaacggat ttggctgccc 3278401 cagccgattt ctttttgttc accgcgaatt tcatccagct ctgcctgctg ctcttcaatt 3278461 ctgcgctgat acagcttggc cttcagcatt ttcatggctc tttcacggtt tttaatttgt 3278521 gagcgctccg tttggcatgt cacaactacg ttcgtcggca agtgagtaat ccgaacggct 3278581 gaatccgtcg tattgacgtg ctgtccgccc gcgccgcttg cacggtacgt gtcaacttta 3278641 atatcctccg tacgaatatc aatatcaatt tcatcgttaa attcaggcat gacttcacat 3278701 gaaacgaaag atgtgtggcg gcggcctgat gaatcaaatg gtgagatccg cacaagacga 3278761 tgaacacctt tttctgcttt gagatacccg taagcgttgt gtcctttgat gagcaatgtc 3278821 actgacttga ttcccgcctc gtcacctgga aggtaatcga gagtctctac tttaaagccg 3278881 cggcgctctc cccatcttgt atacattcta agaagcatag agccccagtc ctgtgactct 3278941 gtaccgccag caccagggtg cagttctaaa atcgcgttat ttttatcata cggctcgctg 3279001 agaagaagct gaagctcaaa ctcattgaac tcttttgtta atgactttag ttctttttca 3279061 agctcaagct ggagatcagt gtccggctct tctttcaaaa gatcatgagt catttgtaat 3279121 tcttcgtggg attcattcaa ttttttatac gaattgacat aatcctttaa accgtttgct 3279181 tcatttataa ccgtttgagc tttttgctga tcattccaga attccggatc agccatttgt 3279241 tcatctagct cagcaatgcg ggcctccttt gattcgaggt caaagagacc ccctaaagtc 3279301 cgctaaacga gaagccatat tttcgagctc tgctctaatt tctgataatt ccatttcatt 3279361 cacctcatta aaagatccgc aggcgcctgc aggcgccgcg gtcagtaaac ttgccggggc 3279421 gaactattca gtacggccgc agcaattttt atattttttc ccgcttccgc agtggcatgg 3279481 ggcatttcgt ccgatatcaa ccactttgcg aaccggtgct ttctttgctt ttttgttatc 3279541 gtcgccttct tgcggctgat gagctgttgt ttgaccttgt acaacctctt cacgctccag 3279601 attgttttca atctcagctt tcatcacaaa ttttgcgact tcgtcctcaa ttgattcaat 3279661 catatgctca aacatcgcaa aaccttccat ttgatactca cgaagcgggt tcgtctgcgc 3279721 gtaagcacga aggtgaatcc cttggcggag ctgatccatc gcatcaatat gatccatcca 3279781 tttagaatca acggcacgaa gaacgataac tttttcgaat tcgcgcattt gctctttgcc 3279841 gaattgctct tccttctcat tatattttgt gatgatgcga tccataatga gctcaagcat 3279901 ttcatccggt tctttgccga agatatcgct cttctcaagt gcaccttcat caagataagt 3279961 tgtgttgata agatcaacta gaccgtcaag cttccactcc tcaggaagct cttctcttgg 3280021 cgtataggct gcaattgcgc gttcgagaga agacttgatc atattttcaa cgatttcacg 3280081 caggttttca gagtcaatga cttcaaagcg ctgcttataa atgacctcac gctgctggcg 3280141 gagaacatca tcatattgca gaagctgttt acgcgaatcg aagttattgc cttcgacgcg 3280201 tttttgagac gattcaaccg cgcgagatac cattttgctt tggattggag tagagtcgtc 3280261 catgccgaag cggtcaagca tcgccattgt ccgctcagct ccgaatctgc gcatcaattc 3280321 atcttccata gaaagataaa attgagtaat ccccgggtct ccctgacgtc cggaacgacc 3280381 tcgaagctga ttgtcaatcc ggcgtgattc atgtcgttct gttccgacta cagcgagccc 3280441 gccaagctct tttacacctt cgccaagctt aatgtccgtt ccgcgccccg ccatgttagt 3280501 cgcaatcgta actgcgcctt tttggccggc ctcttcaatg atctgcgctt cacgttcatg 3280561 gtttttggca tttaacactt gatgcggaat tcctttgttt ttaagcagct tagaaatcaa 3280621 ttcagatgtt tcaacggcaa ccgtaccgac tagaacaggc tgtcccgtca tgtaacgctg 3280681 tgcgacatcc tccgcaactg ccttaaactt tccttccatc gtgcggtaaa ttaaatccgg 3280741 gcggtcatca cggacaacag gcctgttggt agggatcgtg acaacctgca tgttgtagat 3280801 gttgcggaat tcttcttcct ctgtcttagc tgtacccgtc ataccggcaa gtttttcgta 3280861 cattcggaag tagttttgga acgtaatcgt cgccaaggtc atgctttcgt tttgaatctc 3280921 aagcccttcc tttgcttcaa tcgcttggtg aagcccctca ctgtagcggc ggcctttcat 3280981 cagacgtccc gtgaaggaat caacaataac aacctgtccg tcttccacta catagtcaac 3281041 gtccttttgc atcgcaacgt gagcttttaa ggcctggttg atatggtggt tgagcgcgac 3281101 atgcttcaca tcaaagaggt tatcgatgcc gaatgctttt tccgccttcg tcattccttc 3281161 ttcagtaagc tgtacagctt ttgttttgat atcgtacgtg taatccttct ccgcttttaa 3281221 cgtgcggaca aaagcatttg cctgtacgta cagcttagtg gattttgcag cttgtccaga 3281281 aatgataagc ggtgttcttg cttcatcaat taaaatagag tcaacttcat ctattaccgc 3281341 aaaatgaagc gggcgctgaa ccatctgctc tttataaaga accatattgt cacgcaaata 3281401 gtcgaagcca agctcgttgt ttgtggagta agtaatatca gcggcataag cttcccgttt 3281461 ttcgtctttt gacattgagt ttaaattcaa accgacagtc aaaccgagaa actcgaaaat 3281521 tttccccatt tgctcagcgt cacggcttgc caagtattcg ttgacagtca cgacgtgtac 3281581 gcctttaccg gttaacgcat ttaaataaac aggcagggta gacgttaatg ttttcccttc 3281641 ccctgttttc atttccgcta tatttccgtc atgaagcgcc acgcccccca tgagctggac 3281701 tttaaacgga aacatgcctg ttacgcggcg tgaagcttct cgaacaacag cgaaagcttc 3281761 aacaagaaga tcatccgttg tcgccccttt ttcaagacgc tctttaaatt caattgtttt 3281821 atgtttcaat gcgtcgtcag agagattttc atagtctccg cgaatcgcat caatatcgtt 3281881 agcaattttt tcgtatctat tcagcgtacg ttttgttgga tcaaacattt tatttaaaat 3281941 tccaagcatt tataacgctc ctctatcatc acacgcctat tttagaggca tgtataaata 3282001 atttactagt ccatgtatac ctctcattat catatcatac cttttgttat ttccaaagaa 3282061 tttgcaaata agaaaaacaa aaaccttccg cggacatcac ggaaggcttc tcttcattat 3282121 tcagtcggtt caattaagcc atatttcccg tcatttctgc ggtacacgac atttgtaagg 3282181 tttgtttccg catttgtgaa aacaaagaaa ttatggccga gcatattcat ttgcaagatc 3282241 gcttcttcac tatccatcgg ctttaaatta aagcgtttct gacggacgat gtccaagctc 3282301 tcctcctctt ctatgtcatc ctgaaccgca atatctgtat cagagccaag accgtttgcc 3282361 aataaatatt ttggagagcc ctgctcacgg aatttacggt ttactttcgt tttatgctta 3282421 cggatttgac gttccagttt gtttgttgcg agatcaattg cgttgtacat atcctcgtta 3282481 tgcacctcgg accgaagcgc cagatctgtc atcggaatcg taacctcaac cttagactcc 3282541 ttgtcattgt aaaacttcaa gttgacgttc acatcagcat ccacgctatg gtcaaaatag 3282601 cgctccagct tgccgatctt cctctcgaca tgatccttta acgcgggtgt cacttcaata 3282661 ttttctcctc tgatgttata gttcatcaaa gaacgcctcc cttttattaa ggatatgtat 3282721 ctatttctct tttacccttt acaattcctg ctgaaacata aatcttttgt gaaaattcag 3282781 tgaactttgt cgaattttgt ttgtatttgc tctgttattg gcggttcgga ggtatatgta 3282841 tatgctgatt gaacgaaaca aatacctcac acacgcctaa ttgattaaaa agggttccat 3282901 acattgatga atagacagca tccattttct ataatgaatc agaaaatgtt cctttaaata 3282961 ctcacagaac tcatgagagg gaaaagagaa agagaccaat tgatcaaact ccgcaaaaat 3283021 ttggtcaaat gctttcacac aaatttcagc acaccgcgaa tccataatga agagaagtgt 3283081 tgaatgtgtt gaatccaaat aaaaaaaggc ttggatcaga tcttggtaga tccgatcccc 3283141 ttctgttttt gataaattct cttcagcctc tatcaaataa cacaacccct cttcgatggt 3283201 aaaaagaaga tgataataag ctgataaaag cgtataatct tcaatgctct tcaaggcact 3283261 cacctattta cgcttgtcat aatatgtgcc gtcaatcgta atgttgttat aagggtttaa 3283321 atacgtcgta tgcatcacac gttttctttt catctgctga agttctgttg cgattgactg 3283381 cttcagtctt tccatttcct tcacaatcag ctgatcccat gtcaaaataa gtttcatctg 3283441 ctttcgctct tcttctgaaa gcggcagaga tatctcctga atcagttcag accgtgtagc 3283501 cacaaagtct tcaatttgct ttaaaagttc atcgctttcc ggcgtatttt gtatgtgtga 3283561 cagcatactc ttcgtctcag tgtatagttg atctatatta ttcatgcgat cccgcctgat 3283621 ccgtgccggt ccttccgctc actttgaatg gcttgtttcc aagcatcgcg aaaatctgtt 3283681 acataacctt caacctcagc cagcatgccc gtatcatttt tgatatttgc ctgtaccaat 3283741 ctgcgataca tataatcgta catcgcaccc atagaagcgg aaagctctat gttacggtta 3283801 agtgtaaaat ttaattcctg aataatattt tgcgctttaa tcagattttc atttttacgt 3283861 tccatatcat cattctcaat ggcctgagcg gcaagtctta taaatttcaa acagccatta 3283921 tacagcataa gcgtcagctc cccgggtgta gccgtattca ctgaattttg ctgataggct 3283981 gtatatggat tttggatcgc catgtgtcat cctccaaatt acatttattg tacaagaagc 3284041 tgtgataaat aggacgcttg ttcgttcatt ttttgaatcg cagaatccat tgcactgaat 3284101 tttgaataat agcggttttc tatggtattc aatctgtcct gcatatcagt tatttcagta 3284161 cttatcgagt ttaaattttt tccaatggaa tagctactag ctcccattgt cgagttccca 3284221 gctttagctt caatactttt cacagtactt ctaagtgtat tagtaatccg cttcataata 3284281 cctttatcgc tatagttact atcatttgtt ccacttgtaa aaagattagc aactccttga 3284341 ggatcttctg ctatttttgc tttcaatttc tcttcgttaa tctctaagtg ccctcgcagt 3284401 tggtaagcac ttgaagttgt gatgccaaat tcagttaatt gataggtttt cccatccgca 3284461 ttcacttgag tataaaagtc agtccgcatt tggttcgtgc cagtgctgat gcttgaatcg 3284521 tttctcagca atccgctttt cgccttctcc tcccagagct ctacctcttt atcggacatg 3284581 gcttcttttt gttcactcgt gagtggcgta tagtctcggt atttttcttc tttcagcttt 3284641 tcattcaggc tgtcaaccag ttcattgtat ttatctacaa actctttgat ttggttataa 3284701 atcccatcaa catcagtaga aacagatgtg gtaacagggc ctgtggctgc agttgtattt 3284761 ttaatcgaat aagtaacacc attcaccgtg aaattgtttg tcagcttctc catttcaaag 3284821 ccgttgattg tgactttggc atttgtgcct tctttgtaag cagtaagctt attatcagca 3284881 tccaaagaaa aaccaagctg accggacata aagtcagctg tagcagagtc tgctgcctgt 3284941 atgcttcctc ctgcacctgt tgctttagaa gaaaacgcaa tcgtttctac gtactctgta 3285001 ccattccaaa ttttatcttt aaatgctgat actcctagat ctgagctgtt aagtttagaa 3285061 atcacattat caatcgtatc ggcactcgtc acactaatgt tcactgtttt tgctgttgtt 3285121 tcgccaggcg caacaacgtt aaatgccaaa ttgtaatcgc cttgtgtgta tcccgtataa 3285181 ttgtttgcct tatacgttgc tgcagttgcc aagctcgcca cttcaacagt agacgaagaa 3285241 tttggcgcac ttacgcttcc tgtagcagtt aacacagact cattagagct tgtcacagtt 3285301 ttgctctgat acgtgctcgg atatgtcaac gtatttttag acatataatc ttgcaattct 3285361 tttatttttg agtttacttc acgatagctg tcacgctgcc attcaagagt ctgctttttt 3285421 tgtgtcagct tatcaagcgg cgctctttct gtctgcatca gctttgatac gatatcatct 3285481 atatccattc ctgacgccag acctgttatt cttgtgacca tctcaaacca ctcctattct 3285541 actttttttc atctacaaat aacccaagaa attcagtcat agccgcataa aaatcaagcc 3285601 accgttttgg tggaatttcg cggatcactt catttgtaga gtcctctatt acctttacat 3285661 agtattcatt taacttgtca tgaagctcga acttcagatg aacttgcgaa ggttccaaaa 3285721 gcttgttcat ttcccccacc atttcagcaa gattggtata tgaaacttga tgaacaggaa 3285781 cctcgttatc attatctttc tgattatgta tttgagtatc ataacgatcc caaacaggtt 3285841 gtaacgtagt gagcctttca atgttcaatt gatcatcccc tatgccccaa tctatcgttt 3285901 atatcgacta agtcgagata agattacaca tatttttgga aaaaaatctt ctgttttaga 3285961 tttcttgtat ggaaatacat ttataaaaag ttagtggaga atccggttat tatatcatga 3286021 gttagtgaca ggatgaggaa tgattaggag atagaaattt aaattaaaag accctggcaa 3286081 cgccaaggtc ttttttaaaa ttaacgtaat aattgaagta cgttttgcgg ctgttggttt 3286141 gcttgagcaa gcatagcttg agaagcctga gaaagaatgt tgttctttgt gaattcgctc 3286201 atctctttag ccatgtcaac gtcacggata cgagactcag cagctgtcaa gttttcacca 3286261 gaagcgctta agttgttaat tgtgtgctct agacgatttt gtaccgcacc aagcttagca 3286321 cgttgagaag aaacttggtt gatcgcttca tcaacaactt tcaattgagc atcgaaaccg 3286381 atatcagcag tatctgctgc attatctgcg aattttgtta cgtcaagatc attaactgaa 3286441 tgaagagctg caattgaacc atcagcttct ttaattccaa gagcgtcagc acccatatcc 3286501 tcaatattta cagagatttg ctgtgtagca tttgctccga tttggaatac caagttcttt 3286561 tgatttgcag gagtagctgt gtcaactttg taagtgccat cgagcaattt cttaccattg 3286621 aattctgtac gatttgaaat accatcgatt tcatctgtta aagctgaaat ttcatcttga 3286681 atagattgca aatcagttgc tttgtcctga gttccagtgt ttccagcttg aacaactagc 3286741 tcacgaacac gttgaaggat cgcatgagtt tcagttaatg caccctcagc tgtttggata 3286801 agagagattc cgtcttgaga gtttttagaa gccatttcaa gacctctgat ttgtcctctc 3286861 attttttcag agatcgcaag acctgctgcg tcatctcccg cacggttgat gcgaagacct 3286921 gaagaaagtt tctccatgtt cttttggctc gcactgttgt ttgaagacaa acggttcagt 3286981 gtgttaagcg ctgcaatatt gtggttaatt ctcattgttt tgttcctccc tgaatatgtt 3287041 gttaaggcac gtccttgtgc ccttattttg taactggctg agtcttttgc gcctcctccc 3287101 ggctacatca ttaatatcgg attgtctctg attttgttaa tacaaaaata aaaaaatcct 3287161 cacttttttt gtgaggataa tgcggagatc acatcgctgg ataacgctgc tgcacggtta 3287221 ttttcttcct gaatggtcaa gtaaatttct ttcctgtgaa tatcaatatg ctttggggcg 3287281 tcaattccaa gcttcacttg atccccttca accgcaatca cttttacttc aatatcagca 3287341 cctatttgaa tcgcttcgtt tattttccgc gataaaacta gcatgattct cctccaatcg 3287401 gatgctttgt cgtatatgag gagtcgtgta aaacgacttg cttagccatc atgttcttgc 3287461 gattcacaat aatgggagcc aataaattcg cagtagactt ttcaaatggc tctgccatag 3287521 tcaatattgt catgacttct acgtcttgaa tattatcgat atccaaaagt tcagcagttg 3287581 attcatcaag atcaaattca taattcttaa aaaagataaa cggacttacg acgataaacg 3287641 caagattttc tgaagtgacg gactgcagtg ccacgaatgg agagtcttct gaaagcggaa 3287701 gtatgacgaa ctgtttttct tctaaaaagc ctggaatccc gctttcaaaa agaatgattt 3287761 gttcttcttt tatgttcatt tggccatggt acttcgtatg aatgatcatt gttcacgatc 3287821 cttttctttt tacttttcgg gtgattcttt cgggtattct acatctatat ttaaatcagg 3287881 gtattgaagc atgtcaacct taacatttcc tggcgtatat tcaacaattg gcttatgcgg 3287941 ctcagcctga ataacaggct ttcgcggcgt aatctgcaca tcaagctgtg acggagtata 3288001 ttgtattttc accctcgaaa gagaaggagc ataattttcg cctaattgaa tttggtgcat 3288061 ttcagagttc ctccttgctt gtgaagcgat tgggttcccc ttattttcaa tcttcataag 3288121 ctcgtcgcct tcttctgcag tgcgtgctat tccctccatt acatcctcat gcccttgttg 3288181 ggcggcttct tcaattctct tgaaaacatg ctttctgtct aattcttccc atgcttgtgt 3288241 ctggtcaatc gtgagttttc caggtgtcac cgatatttcc atttccgcac tcggctgttc 3288301 gatctctaga tcagcttgag gctgctccat ttttaagctg gcaggcgtcg ttgttaaacc 3288361 aatttttcct tgaacactat gcataatcaa tctgggaatc tgcatcactc tacctcctga 3288421 actataaaaa aagcgaactc ctaagagccg cttactttaa aaagtcaatc aatgtaggct 3288481 gaacaatttg cgcattaacg gccagagtag ccctgtgcac actttgctgc gcaataaatt 3288541 cagttattac ttcttccagt tctacatctt cattgtctga taacactttg gtagctgttt 3288601 cttcttgcgc tgacagtctt gtattaacca gttcaagacg attatatctc gctccaagat 3288661 cagatcgttc agcgctcatg ccgtcagaaa aatgatcaat atcatttaaa acactgtcca 3288721 tgccatctag cgaaccagaa tttagtgctt tctcaaaaga atcaagcatt tcaaatacat 3288781 tctgcccgct ttcagaagtg cctccaaaag ctgactttgg atctgaattc actttcaatg 3288841 acatattatt tgatatattg actacgacat cagctgtatc agaaattgta taagttccgt 3288901 ctccgttatc tgtaaccgga ggcttatctg aatttgtgcc attaaagata tatctgccgt 3288961 tcacttgtgt attcgcaata tttaaaagct gttcctttaa ctgctttacc tctacgccaa 3289021 tcgcttgccg ctccggctcg ccgtttgtat cattttgagc ttcaaccgct aattctctga 3289081 cctttgacaa gatgtcaatt ccttctgtaa tgtttgtttc tgtgttttcg agccaggtaa 3289141 aggcttgaga agcattgctt ttgtactgct gcacttgaga cagttgcgta ttatacttta 3289201 agcttttcat tgctactaca ggatcgtcgg aagcttttga gatttttttt cctgaagaaa 3289261 tctgcgactg gagtttatcc agcttcgagt agcttgaacc gatatatctc agtgagtttt 3289321 gctgtatcat gccttgtgtt actctcatgt gactctacct accttcctcc aacacccatg 3289381 ccgttgatca ctttatcaag caattcgtct tgtaaagtca ccattcttgc agctgcattg 3289441 tatgcgtgtt ggaattgaat catattcgtc atttcttcgt ctaaagaaac tgcgctcatt 3289501 tgctgacggt ttatgtcagc atcattcagc tgtgtttctg tattagacgc cagtcgatta 3289561 gcctcttgag cttcgatccc tagctcgcca atcagacccg cataataatc taaaacacta 3289621 gtttctttac cgttaatggt tattttaccg gttaaaacat ttgctaattt tgtagcattt 3289681 gcgttatcgt tggctgcgcc agtcagtgag aaagcaatgt ttgcgccttt tgaatctatt 3289741 atgctgtcag ccactttgat cttgcccgcc gcgcccttgg caggttcagt ttcaccgcca 3289801 gtaaaatcaa aaaagtctcc gccttgttca ccgctcttgg tcacaccatt tctgtgcact 3289861 tcattgaaag ctttcgcgaa ttcaagcgcc atattgtcaa gatcagaaag catttccggg 3289921 tatacgccct tttcttggcc atctgctgtt atatacccat aagactctat aaaccctaaa 3289981 agggatccct tgctgctaaa ggactccgcc tgtacagctg tatccccgat tgaaatactt 3290041 gatactaacc cagtttcatt atcatagttg gctgcaagtt ctgaaacctc gtaattttta 3290101 ccgtccaaaa cagttcctag cgactgttta tttttatcaa ggatttcaat tgatacagtt 3290161 ccttcagcag atgcaagtgc attcccgcct gatttgttgt agctgacttt gatatcaacc 3290221 attgaggata atttatcgat cagcaaatct cgctggtcat ataagccatt cggaagaagc 3290281 ccgaccggct ctacttgtgc aatttgctta tttaaactgt ttaactgaga aagcagagaa 3290341 ttgacatcca acacagttgt atttagctct gcttttaaat tcgattggac atttgtaagt 3290401 gattcagaaa tataattaaa cgtttcagct acagcttgtc cttttcgagc aacaacagaa 3290461 cgtgcacttt cttcatttgt attattcgat aattcctgca gggaattcca aaacgaattg 3290521 agcacactgt tcaagccgct gtcatccgtt tcatttaaaa cgccttccat ttgggacagc 3290581 gcttttgcct tcgtgtcata gtatccggca ctgttgtttt gaagacggta ttggtagtca 3290641 agaaagatat ctcttattct ctcaactgat tttccttgaa cgcccgtacc catttgtccc 3290701 gctgtttttt ctgcattttt agatacagca gggaaatagt cagttgcctc caatgagacc 3290761 cgctgtcttg tataaccatc agtattggca tttgccacgt tatttgcagt agtgcttaac 3290821 gctgcctgct gagcgcttaa cgcccgcctt gcagtttcaa gccccataaa ggtagatgtc 3290881 attttctgaa ttcctttctg ctaagctttt gaatcaaaca gtttcatttt gctacttttc 3290941 ggcagctcag ctttaattga tttgctgtaa ttgaagttat tttccttagg aaccagcata 3291001 tcgtacgaaa tagagatgaa ttgcagcgcg tctcttgtca gctgcctatt catctcattt 3291061 acttttttca gacgtccgag aacttgagaa agagattcgt atagttgttc cagctcttcc 3291121 ttttcactgc ctgaggtttt ggcgatacat gcggaaatag tattattttc gctatatccg 3291181 agaaaggccg aagttgtttt gatccggtca tcttctgtct gcgtgattgc ttgaatatat 3291241 ttttgctctt ttgtcaaaat gttagaaagc tcttttgttt tgccggcttt gagcgcttcc 3291301 gtcttttctt cagacagcgt gagcaggtgc tcatgcagaa cgcaaagtcg cttcaattgt 3291361 tcaataattg ccttcgctga catgggcttt ctcctttttt attgcttttt ataaaaatta 3291421 atcatatttt tcgcaatatg atttgcgtct actttgtatg acccgttttc aatttgcgct 3291481 ttaagctgcg caattttttc ctgtcgtgaa ccagtgactg cgtcggatgc atgttgcatt 3291541 tctttagcct gtgatgaaat ttcaatttta tcttgaggtt gtgcaacagt tttttgcacc 3291601 gcttgcttat cataattttt ttgatatgga ttaacggatt gtgttccaaa ttgattgatt 3291661 ttcataggat tcctctcgct ttccgttgca gtctttaaac aatcttaacc cttttatcga 3291721 ctgcgttttc agttagttta gggaatcagc tgtttttggt attataggca tagtatgtgt 3291781 cttttttact attttctttc tcgattttca gagcatcctc gtggttcaaa tgatccattt 3291841 gatccttaat atcagactgg caagccttgc agaacttgcc ttctctaatc gatgtcccgc 3291901 acctttcaca agggtatgcc aaattaggaa gatgagtgat ctgaattcgc ttctgcctga 3291961 tgaatttcaa tatcagctct tcttccacac ctgtttcctc agttatccgg ctcaaagttg 3292021 attgccggtt ttcctgtttt cttaaaaatt tatagacagt ctcaaatgat ttttcttctt 3292081 ccttaataca cgcctgacat acggtttgca gctttgtttt taaaaataaa gcattgcatt 3292141 tcggacaatt agccagttct cccatctttt tttctcctta ttagataata tgcctgtgtc 3292201 aatttctagt gattatatcg gcataaaaac agaatcattt agcttctgat caaggtaaaa 3292261 gatgacactg aagcggcttt tcctttttct aataagcagc gggctgcgaa gtgcaaggtg 3292321 gcgcctgttg tataaagatc gtctattaaa atgatattca taccttctgc tgaattattt 3292381 tttgtatcaa aaatgcactc tgacagcagg cgttctgttt tctttttctt tgactgtttc 3292441 tcattattca ggcgaatgag gggatggtgg gaaggccggt ctaaacattc tgccaagaga 3292501 tgtgcctggt taaatccgcg ctcttcttcc cgttccttgc tcagcggaat aggtacaaga 3292561 acaaaatgct tatcggggta aaccttagaa aaggttgaag aaaaatcact tttaaatgca 3292621 tttatgattt ctgcatctcc tctaaattta aaacgggaga gcgtttcttt catcatatca 3292681 ttatatgtgt aaactgaacg gttttgacgc aatagcaaac tgtctctgat ccttgttctc 3292741 cacacctcgc aatccctgca tacggcatga acagattgag gtctgccgca cagggggcag 3292801 atatgtcctg tgattttctt taatttgctt ctgcaagaat aacaaacctt ttcatcaggc 3292861 tttagtaaaa aaagggctct ccatgtaaca tcttgagaaa attgcgaatc acataataaa 3292921 cagatcagtt tatgaatgcc tcctcctgct tcgtttgaca taaatcgctt ggactctctg 3292981 aaactactgc agcagattca gccaaaatga caagcattgc tgtgtttttt tgtttatcta 3293041 ccagctcagc tttcgtatat gcgatctttt taaaatcagt aacgtaggat ggactcactt 3293101 tgtttaaaga aagtgccaat acatcgtttt ggcatacttg gcaagtacag gccatatgaa 3293161 gctggtccat atatcggtcg agcagttctt tcattacgat ttcttttgaa ttgacaagca 3293221 tttttacagc tcctcatcat cggttatatg agtatactgt accacgtttt caaataatgg 3293281 ctagtctgta cattcaactt ttgctgccaa ttcattcatt tcttttatat gctttcttgc 3293341 atcgagcata ctctttgttt tgccgaagtg aaagtaaatg acatcgccgt ccgcatattc 3293401 tttatgccgg ccggttcttc ctgcaatttg aacaagtgcg ctttccgtaa agatagacga 3293461 ttccgctcct agtacacccg tttgcacctt ggggactgtg acgcctcttt ccagtattgt 3293521 tgttgtgatt aatagatcga gctgaccatc tctgaattgc tgcactttct cctttctatg 3293581 cttgtcttcc gcgtgcacag atgcggttcg gcaatgaaca cctttaaagc acgcagcagc 3293641 cttttccaga atagaaacgg aaggaacgaa taaaaaaaca ggcctccctt cttttacatg 3293701 aaactctatc catcttttca ccgctggcgg aattttattt cggtttaatt tcttcttcca 3293761 gtttccacac catacaaagc gcggttcggg taaaggtttc cggtggtgtc ttgcggggat 3293821 gcgaactgaa tgtaactgtc cgttcagtgc ttttcttttt aattctttag gaggtgttgc 3293881 acttaaataa acgagggtgc tgtttttctt tcttgctttt tgaacagcga attgaagggt 3293941 ttgatcagca gaatatggaa aagcgtcaac ttcatcaatg atcataacat cgattgcatc 3294001 tttatatcgc aaaagctgat gcgtagtgga aatcataagc ggagatagcc gccctttgtc 3294061 atcgcttcct ccgtaaagcg ctgaaatgtc agcaccctga aaggcagcct tgagtcttgg 3294121 agcaagctct aatacaacat cggtgcgagg tgttgcaata catacacgca gtccttgatt 3294181 taacgctgat tctataccag gaaacagcat ttctgttttg ccagcgccgc aaaccgccca 3294241 gatgaggagc tcttcttttt ttgatattgc ttcaattaaa acattggcgg ctttttgctg 3294301 tccgcttgaa agcttgccat cccatgtcag cttaatagac ttccagtttg attcattttc 3294361 ctctttccat gaatataaag gaacctcctc actcactctg cccatcatga cacaggaacg 3294421 gcaatacagc ttattctttc cagatgagtg ataaaaagaa aaataccgct gatcagtttg 3294481 tccgcaccta ttacatctat atctccgttt atttatggat atagaatttt cagcagtgat 3294541 atatccattc ttgatatgcc attcaatcat ctcatcggaa aatgagagct cagtcctgag 3294601 caaatgacgg cttcgaagcg tctgctgcaa ttcttttgaa aaggaactgt ttttttcaac 3294661 tggcacattc acatagcacg cctcctttcg aaacagtatg cctgaatgaa tattttctgt 3294721 ccaactatta aaataagaat ataaaaaaat ctccgctcta aaaacggaga tttggcctta 3294781 tttaaaacac cagcaaattc ctaacgcacc ttcacccaaa tgagtgccga ttaccgcgcc 3294841 aaaatagctg ttataaaatt caacatgagg atattttgca gaaagctctt caatgatttt 3294901 cgctgcttct tcctctcgat tagcgtggat aacagcagct cgcataggca accctttact 3294961 cgcatcttcg tctaaaagct cataaattcg cgaaattgct tttttacgtg tgcgaatctt 3295021 ctcaaaaggc acaattacct tattgtcaaa atgaaggata ggctttacct ttagaagact 3295081 accaatgaag gcttgggcgc tgcttaatcg cccgccgcgc tgaagatggg ctaagtcatc 3295141 taccataaaa taagctcgaa ctgttttttt catttcttcc agttctttta taatatcttc 3295201 cggcgatgat gctccgtttt tgattaattc agcagcttta agggcataaa agccttgagc 3295261 caagcagctg atctctgagt caaatggata cacatcaata ttgtcgacca tcgaatcagc 3295321 cgctgctgca ctgctgaatg ttccgctgat cccgctggaa agatggatac tgataaccgc 3295381 atcataagac ttgccaagct cttcatacaa cgcaaccagc tcgccgattg gcggctgaga 3295441 agtcgtcggg agctcattat gttttttcac ttcttcataa aagcttttcc agtccaactc 3295501 aatttcttca cggtaagtct cctccctaaa aacaacctgg agagggatca tatgtatctg 3295561 atgttgttca cgcatttctt tcggaatata tgccgtgctg tctgttacga ctgcaatatt 3295621 catagcttcg atacctgcct tattgcttta taactctatt gtaagggaaa cggcagccta 3295681 aaaaaagacc tgcctagtaa aaggcaagtc tcctattata ctatctcatt tctacccagc 3295741 catttttaat ggcgaccaca acggcttgcg tccggtcgtt tacattcatt ttttgtaaaa 3295801 tattgctgac atggttttta acggttttct cactgataaa caatgattca ccaataccgc 3295861 ggttgctttt tccgtctgca agcatctgca gcacttcaca ttcccgccta gttaaaatat 3295921 gtaatggtct gcggatttca gggtaaacct catgttgagg gtgtgcagaa actccgcttg 3295981 ttgcaaggcg gcggaattcg ttaacgaggt tgtgagtaac cttcggatgg aggtaagatc 3296041 cgccctcagc cactacttta accgcttcaa ttaatgtatc agcatccatc tctttcagca 3296101 gataacctct tgcacctgtt ttcagggcat gtgttacata attttcgtca tcgtgaattg 3296161 atagaataat tactttagat tcaggataca gctctacaag ctgttttgta gcttccacac 3296221 catttacgtt tggcatattg atatccatga tcacaacatc aggatgatag tgctcaacaa 3296281 tacgagccgc ttcgtccccg tcatcacctt cggctaccac ttcaaaggta ggttcaaaat 3296341 ccaatatccg tttaacacct tcacgaaata actgatggtc gtcgataata acaatgttta 3296401 ctttagtcac aagccacgcc tccttgtatt attgttctat atactctagc attcggtcaa 3296461 tatgcctttt ggctctattt tacaaatcat agtcaaagag ataacggaac cttaatcata 3296521 ataaatgtcc caagacctat tttcgaatct attgtcatcg ttccttccaa taaatctact 3296581 ctttctttca tgcccagcaa gccgaatgat ttgtttttct tctctttcgc ttccttcagg 3296641 tcgaaccctt taccgttatc ttttatcatt aaaatcacaa aatcctttgt gatctcaact 3296701 ttgactgtaa tttcttcaga ttcagaatgc tttagcgcat tagacacagc ttcctgtgcg 3296761 agcctgaaga gcgcaacctc aaactgaggc gctagcctct gatcctctgt ttctccaatg 3296821 cactgaaaat gtattttgac cttcccgtta tattcctcgg ttgtatatag atattttctt 3296881 aaagttggaa tcaggcctag gtcatcaagg gccatcggtc ttaaatcata tataatcctt 3296941 ctcacttcgt aaagggcatt ccgaacattt tggcggagat ttttaatttc ttggaatccg 3297001 tcctctgcgc cccggtcacg gaaaatccgc tcgattaatt ccgatctcat cataacattc 3297061 gccagcattt gagcgggtcc gtcatggatt tctcttgaga ctctttttcg ctcttcttcc 3297121 tgcgcctcaa taattcttaa gccgaaatcc tgttttgcct gagcatcagc aagaagcagt 3297181 ccaacttcgc gcaaatcctg attcaagtag ttgagcacaa ctgtaatttg gcttactaat 3297241 gattctgacc gctcaatgat ttcctgaagc cctagcaatc tgcgctccaa atcgtcccgc 3297301 cgttcgcgca attgcttctc acgctgctgg atcatcgtca attctacctg cagcttatgg 3297361 gctttttcat aagcattgcg gatttcctct tcactgaatc tatgaaaatt acggctgacc 3297421 tcggataaac ggtttctcgc atggcgagtt tgcacttcaa gtttatcgcc aagctcaatc 3297481 acttcataca cctgctgttt aatttgtttc agttcttcga ccagctgttc atactgctgg 3297541 cgtgactgct ccccgatttg aaaaacctcg tccttgctcc cgtcaacggt tttcagcatc 3297601 ttcatcaaaa tagaatccag cactttggaa tccatctttg ttttattcat aatttccctc 3297661 cgtcacggcg ttgtcatata tttttattat aaatgtaatt gatctgcaaa ttatgtcgaa 3297721 ttataatgaa agaatgcgta tattctagaa aaaaacattt ttatatacta tctactcttt 3297781 atgataccaa aatacgcaca aaaattctaa agactgtacg aatttgtata ggcagtcttt 3297841 tatgcttagc aggagggtca gctagcatgc tgcacagcta ttttactgtg aaagaagcgg 3297901 gagaacacga gattgttata gaaaaatcgc gttttatctg tcatttaagc cgtgtttcta 3297961 ccgaacaaga ggcacaggaa tttatacaga aaataaagaa acagcactgg aatgcgactc 3298021 ataattgctc ggcttatgtt attggcgaga atgatcatat ccaaaaagcc aatgatgacg 3298081 gggaaccaag cggtacagcg ggagtgccga tgctcgaggt tttaaaaaaa cgcaggctga 3298141 aggatacttg cgccgtcgtt acacgctact tcggaggcat taagcttggt gctggcggat 3298201 taattcgcgc ttatgggaaa tcagtgtctg aaggattaaa tcatataggt gttgtagaac 3298261 ggaagcttat gcgaatcatg catacttctg cagattacac atggcttggc aagattgaaa 3298321 atgaattaag ggagtcacaa tttctgttaa aggaaatcca ttattcagaa aatgttgaat 3298381 tcgaaacata cgtggaagaa aaagaaacca acgctttttc tgaatggatg acagaactga 3298441 caaatggaaa gagtgatatt aaagagggag agttgacgta tcttgaaaaa gccgtcaatc 3298501 acataaagga gactgaataa tggctgaacg cgttagagtg cgtgtgcgaa aaaagaaaaa 3298561 gagcaaacgt aggaaaattt taaaaagaat aatgttattg ttcgcccttg cactattggt 3298621 agttgtaggg cttggcgggt ataaacttta taaaaccatt aacgctgcgg atgaatcgta 3298681 cgatgcccta tcccgcggga ataaatcaaa tcttcgcaac gaagttgtag acatgaagaa 3298741 aaaaccattt tctattttat ttatgggaat agaggattac gcgactaaag gacaaaaagg 3298801 gagatcagac tctcttattg ttgttaccct ggatcccaaa aataaaacca tgaaaatgct 3298861 gagcattccg cgtgacacac gtgtgcaatt agctggtgac acaacgggaa gcaagacgaa 3298921 gatcaatgcc gcttacagca aaggcggtaa agatgaaaca gttgaaactg ttgaaaactt 3298981 cttgcaaatc ccgatcgata aatatgtcac agttgatttt gacggattta aagatgtgat 3299041 taatgaagtc ggcggtattg atgttgacgt gcctttcgat ttcgatgaaa aaagtgatgt 3299101 agacgaaagc aaacggattt acttcaaaaa aggcgagatg catttgaacg gcgaagaagc 3299161 cttagcatat gcccggatga gaaaacagga taaacgcgga gactttggcc gtaatgacag 3299221 acaaaaacaa atcttaaacg cgctgattga ccgcatgtca agtgcaagca acattgctaa 3299281 aattgataaa atcgcagaaa aagccagcga aaacgttgaa accaatattc gcattactga 3299341 aggtttagcg cttcagcaga tttacagcgg ctttaccagc aaaaaaatcg acacattgag 3299401 cattacaggt tctgatttgt atttagggcc taacaacaca tattactttg aacctgatgc 3299461 tacaaatctc gagaaagtca gaaaaacgct tcaagagcat ttagattata ctcctgatac 3299521 aagcactggc acttccggta ccgaagacgg gactgacagc tcaagcagtt ctggcagcac 3299581 tggcagcact ggcacaacaa ctgacgggac gacgaacgga agcagctatt cgaatgacag 3299641 cagcacaagc tcaaacaaca gtacaacgaa ttcaacaact gattcatcct attaaaaaat 3299701 gcccggtcct tttagaggat cgggcatttt tgcgcagaaa aaaactccgg cacataagcc 3299761 ggagttttta attccttttc accagccgtt tataaaactt tgtaaacggc ttaaattttt 3299821 cattcacgag tcctgtcact tctgctatga tttgcataaa aataatcaaa atgaagataa 3299881 taaacaaaga aagccaaatt gtggcacttt taagtacaat cgcactgata ctgaaaataa 3299941 atccaattaa ataaataact aagaccgaca tccgatgtga aaggccaaag gccatcagtc 3300001 tatggtgaat atgcgactta tcaggcgctg aaatcggctg tttgtttaat attcttctga 3300061 tgatagcaaa tgttgtatca aaaatcggta cgcctaatat aataatcggg ataacgatac 3300121 tgaacaatgt gacactttta tacaggccta ataatgaaag aatcgagata ctatacccta 3300181 aaaacagtga tcccgtatct cccataaaga tttttgccgg atggaagttg taaaacaaaa 3300241 accccagcgt gctggcaata acgactaatg agagtgacag aatgagcact tttccgccgg 3300301 atagcgccat gacagcaatc gttgacaggc cgataacaga aagaccggca gcaaggccat 3300361 ccaatccatc aatcaggtta attgcgttcg tgatgccgac aatccataat accgtcagcg 3300421 gataagccat ccatcctaac tcaaatcgtt ctgttaaaaa aggtactgag aaaaagtcca 3300481 tttttaagcc agtgcttaca atcataatgg ctacacctaa ttgaatcaaa aacttaactt 3300541 ttgcacttaa ttgatattta tcgtcaagaa tacctaacac aataatgatg aatgctccga 3300601 ctgtaattgc cgtcatcctt gtttctgtgt aaataccgga tgcaagcacg cctgcaacca 3300661 ccccgataaa tatggccagc ccgcccatgc ggggcatgat tttgtcatgt acttttcgat 3300721 tgctgggctg gtcaactgca cctattttaa tcgcaatcct ttttacgatt ggggttatga 3300781 ttaaaactgt cagcagcgag acaataaacg caacaacaat gcgaatcatg cgttcgtcaa 3300841 gcataaagaa gtctcctttg gaattaaatg aagtctttat ttatatagag aaccgttcct 3300901 tccattatac cttctcctta gttattataa caagcttcat caaaaagaaa cacgtataat 3300961 caaaaaacgc gcatcccaat ttataggact acgcatgttt ttgaatccct gtatatttca 3301021 taatttgtct aaataagcaa ttccaatctt gtgtccgggc gatgtttcgg cgcatttctt 3301081 tataggtctc gtctccgttt tgaccgagaa ctttttcaca agcggctata aaatcaatcg 3301141 gatgatcgcc ctctacatat tcgtatacat acggcttttg catttttgag gttgacggaa 3301201 gattagtgcc tacaacaggt tttcctgccg ctaaaaattc aaatagtttc agcggaaaca 3301261 cagcttgatt atacggtgat tgtttatatg gcataatgcc aatgtcgata agctccatat 3301321 aatgaggcac ttcttttgga tctgccggac cggtccatat gacattggga agcctcagca 3301381 gctcttgaaa cgaaacatca ccattggtgg catccgggcc aacccataaa aatgtccaat 3301441 caggcttttg cagtgccgct tctttaatca ttttaaaatc gagcttcggt ttaatcccgc 3301501 caataaaacc taacactatt ccttctctcc cctgcagtat actgcgatcg ggagcttgtt 3301561 tatttgcaga aaacagctca tactccacac cgttttccac agtatgaacc ttttctcgtc 3301621 ctgcagtcag ttttttgtct acttccttgt gaagataatc tgatgaacag gttattgaat 3301681 ctgctcgttg tataattctc agctctgccg atttaatgac ttttcgccgg aattcagaca 3301741 gcagatttga tcggccgctg atcggcgcag cccataggtc actgcagtca taaatgacct 3301801 gatcccaaga atacagcgaa gacagcagcg ggaatccggg aaacgtgtac cataaacagc 3301861 agcgttcacc gtttgcagaa gcaggtgtaa gctcatcgag taatggggag agcttatgtc 3301921 tgtaaaagac atctgtatat cgtccgaaac gaaacatttt tttctgcagc aggtctttga 3301981 cagcgaattg cctgatgcca gaatggactt cctgaaactc tttcccttgg gcacgcggag 3302041 ccggacatac ccaaataact tccttcgttt cctcctgagc agctaaaaat tctgccagcc 3302101 ggtgccttct gtatctcaat tggtcttttc cccattcagc agtggcaacg atgacatgaa 3302161 tgattgcttc ttttgtttcc accttcatca ccttttctct ctgtttgcag ctataatctt 3302221 tttttcaccg cgttttttgc atattgaaca aaacaccatg ttgctttcat aaaatgaagc 3302281 cgttcgatct ccctgtagac aaaccacgtt tttttcgcag ccttccattt gttgctggaa 3302341 attgaattat tgacaagccg atattcagcc aggcattcat tcattccata ggcagtaaat 3302401 ccttttttta aaagagacag ccatgtggct aagtcctgtc tcgttctgat attcggcatt 3302461 tggatctgtc ccgtttgctc cctgtcaatc atcaccgtca agcagccgat aattgtattt 3302521 ttcagggcgt catcgtacgt caggctttcc ggcgcatgaa taaatttatc gagcggggtc 3302581 ccgtcctgcg ccattaagct gtagcccgtg aaagagaacg cacaggagcg ctccatcata 3302641 aactcaagct gcttttccag tttgtctttt ttccatttgt catcactgtc caaaaatgct 3302701 acgtagcgcc cttgagcgcg ttccaacgct ttgttgcgag caaccgcagc tccggagttc 3302761 tcttccagat acaccacatg aattctttcg tctatttttt catactgctg taaaatgtcg 3302821 cgggtcccat ccgttgagca atcatccacg ataatcattt cccaatgagg atggctctga 3302881 tctaataccg aatgaaccgt gtcttcaata tagtcacgcg cattatagga aggtgtaatg 3302941 acagatacga gaggtttcca attggtcatg atcacatctc catcgtatga ttttaaaagg 3303001 attctctgaa aaattcagga atgacaacga acataaaggc aatcgtaagg ccaatcataa 3303061 cgccgagaac tgctttcttt ttcggagaca taccgccgcc tgctgtctca cttacggttt 3303121 cggaatcagt aacacttgcc gctttcaggt taagctgtgt gtttttgagt tcatataaaa 3303181 atctctcttt atccactttg gaatcctcgc tcaccgactc gccttcaagc gcgtctatgc 3303241 tgctgcggat gacggcttct ctttctgcat acagcttttg atcgtttttg aggaaggtgg 3303301 aggatatggc gtttaagaca gattccgttc tatccttatc ctcgtcacta tagcttaaag 3303361 tcagtaacga tttggattcc gtattgattg taagcttctc tttgatctct gctacatctt 3303421 catccttttc atcaggaagc gcctccttca aaaaggagtc gctctttaat agaagcggaa 3303481 tctcttctgt gctgttataa accggatgat catagctccc cacagccaaa gtatcttcag 3303541 ctgtatagct cttttgatca gcgatctgtg acggcaggat ataccccgcc gcacctaata 3303601 taattggcac cgctatgatc caaatgatat ttttttttat gcgacgggct attcttatca 3303661 atatatcgtt catataagtc tccctgcttt ttgtagtctg tttatctgta catcggctca 3303721 ggcatttgtc tggatcgcct taacacattc acggcggcga tgacgagcgc cataaacacc 3303781 caatggaaaa ataaatttga aacagagctt gggctgatac ttgataccag gaaactgacc 3303841 atagcggtaa taagtccttc tgtgatcagt tttgactgat tttctaattt tctttcataa 3303901 aacttgtaaa gcacccatat gaggtaggca taaacggaca aatatcccag catgatgaac 3303961 aaaccaaaat tagcaagaat ttcaacaagc cagttatgca cctctgccac attgtcagta 3304021 tcatatacag cataatgctc aagataatag gatacatttc ctgccccgac tccgaatccg 3304081 tatgaatcaa ggaaaaaatg ccaagcgttt ttcagcagat ttgcccgagc cacatttgat 3304141 ggaagcctgt catgaaatga atgcagcgtc tgcggggcca gaaacagctc ccaaaacttt 3304201 gaatagattt tgctggcgaa aagaactgcg aaaagagcaa ttcccgccgc cgacagccat 3304261 atagccattc tctttaaaac aggcggcaat acaatgaaga tgtagacagc aatacctgca 3304321 aaaatgccca gaaggctggc tcttgaacca gtggcaaaaa ttaaatacaa cgcacagagc 3304381 gagagcacaa ggccaattgc cttgatgtat ccattcttaa tgtttttcat catcgtgatg 3304441 taaaaaaaga agctgatgga taaaaaggtc gcaaagtcat tttgattaaa aaagaccgat 3304501 gtcggataat gctgcttgta ctccggtccg ctgtacaatg tggaactcgc aagatgatgg 3304561 tgggtgatat gattgtaaaa accaatgatc atcagaaata ccgtcatcac cagccaaatg 3304621 gcataaacaa tcatcagccg ctccattttt tgcacgtaca tgacaataag ataaatgaag 3304681 aagatcccca ttgccaataa ggctaaatac ttgaggccaa ctgttaccga cttggcccac 3304741 agcagagaaa caaggccata tataaaccaa aaggcgaaaa agagtaaaat cccttttact 3304801 tgcagcccat gccatctttc aatatgggtt cgattccgaa ccatgccgaa aatatgaagg 3304861 caacccgctg caatgagcag aagccggtaa aggaacaaac tgaaaaatcc aagatgaatg 3304921 gcaaaaaatg cattatttaa aaaagtgcag gcgatcaaaa tatagattac agccataaag 3304981 agccgttctt ttgttgtaaa tgcggttgca agcgtcagta aaaacaggcc aattgccaac 3305041 accgcaagca cagcagccat ctgcatgaaa cctatatctt tatggatggc tcccagcaat 3305101 aggacgactc caaatatagc agcggccagt aacgctagcg tatggaccgc tgatcgtttg 3305161 atactcacat gtttaacccc tttcctgatg tttcaggagc cggcggccga gcctagcagc 3305221 cggcagcttc aaccaagtaa cactttttct ttttataaat tgacgcttcc caagtcttta 3305281 gccaattctt caagcggcaa gcccggaaaa tacttgtcag agggttccgt tccccgaaca 3305341 gcgggacggc cgatagagtg ataaatgtat ccggctgcct gcatctcttc aagtgaaaat 3305401 aaatttctgc cgtcaatgat gactggctgt tttaagaggg ttttcacttt tacaagctcc 3305461 atttctttca cttccggcca atccgttaaa atcaggcatg catcagtgtc ttccatcgca 3305521 gcatacacat ctgtgtaata ctcgacctgt tcgccaagga tcgctgaagc ttcaggaata 3305581 gcaatcggat cgtatgcttt tacatgggcg cccagctgct gcagcattgg gataatatca 3305641 agcgctggag cggatctcac atcgttcgta ttcggtttga aggctaatcc caggactgaa 3305701 atggttctcc ctttgacgct tcccataaca gtcaaaagtt tatctacaat atgaacacgc 3305761 tgcttttcgt tcgtttcaat gacagcttcg atgagcttga atggatagcc tgccgatttt 3305821 gcgatttgaa gcagcgcggt tgtatccttt ggaaaacatg aaccgccgaa tccaatacca 3305881 gctttaagga actttctgcc gatacggctg tcaagaccaa caccatcagc aacttttgaa 3305941 acgtctgcgc cgactcgctc acaaatgttt gcgatatcgt tgataaagga aatctttgtc 3306001 gccagaaatg cattcgcggc gtatttaatc atttctgcac tttctaggtt tgttttaatg 3306061 acaggagcat ggaatggctg atgaagttcc tcaatgatgg cagcggcttt atgacttgtt 3306121 gaaccaatca cggcacgctc catattcatc gtgtcatgaa tcgctgaccc ttcccgaagg 3306181 aattcagggt tagatacaac atcaaatgag tatctcccct ttgaggcttt ttgaacgata 3306241 gattgcacca gtttccctgt tccaaccggg actgtgcttt tatttacgat cactttgtag 3306301 ccgttaagat gctcaccgat tgttttcgcc gccgctttga cgtacgttaa atcagcttca 3306361 cctgttttgg acataggcgt tccgactgca atataaataa tatctgaggc ccgaatggca 3306421 gacgggatat cgttcgtaaa ggtcaggcgc tgatccagca catttttttc aactaagtct 3306481 gcaagccctg gttcatagat tgggattacc ccatttttca ggcttctgat ttttgattca 3306541 tcgatatcac agcaaacaac tttattgccg atctccgcaa agcaagtgcc tgatacgagt 3306601 cctacataac ctgttccaat gacagctatt tttttcacag cgctcaaccc tctcctgtaa 3306661 aatgatcttc caatttataa tggtcgcagt gtcttacgat taaacggacg ttttcgtgac 3306721 cgtctgatac tgatgatgca aggccttggc gttttttcct gcgtcaaatt gagcctgcac 3306781 ggtttcatac aagtcatctg ctacttccgg cttccatatt tgctcatgtt cgtaccgagt 3306841 gatcgcttcc gccaaggctt gagcggattt cggtttaatc agcagatgtt ggtgctttcc 3306901 gaataaagac gacactccgc caacatccgt acaaataaca ggaaccctta gcgccagcgc 3306961 ctcaatcaca acagtcggca tcccctcact gtaagaagga agtacgaata gatctgccgc 3307021 aagtaaatag tctcttacct gatgattcgg gacttggcct gtgacgatat gccccttctg 3307081 cgtcagcgtc gattttgcgg gaccatcccc gacaaagact gccttaggag agtcctgcag 3307141 cgattcgatc gcttcagaca gttcaaaaat gcctttctct ctgaccagcc ggccgacata 3307201 gacagccaga cgctgatcga gcgggagtcc gagtcttttt ctgatttcct ctttcgtctc 3307261 ctcattcccc tgaaaacggc tgagctgtat gccgattggc aaaaccgagc tgtcaaagcc 3307321 cgaaagcttt ttggcttctt cctgaagctt gtggctgact gctaaaacaa ctgacgcaga 3307381 acctacggca cgcttgaagg ctttaaacgc acctttgctg taatgcggat agacattcac 3307441 atcactgcca tgcaaggtca ggacataagg aatttgcgct gactctgaca cgactgccgc 3307501 agccccgccc gatggcatgg caaaatgcgc atggatcaga tccggatata ggtcgcgctg 3307561 tttcattgtt tttaaaacgg ctgatgcgat tctccgatga ggctgcgccc acttcagctg 3307621 gccgggaact gcccgataga aaggccggta aaccggtatc ccctttctaa tctcatactc 3307681 cggtctgaca tccttttttc gatatgtctt tttcagcatg cggacaggtg ctgaatgaaa 3307741 aggccgtggg catatcacag tgatatcaag cccgagtttt tgcagctctt gcacctgtgt 3307801 ctcatgaaac acaccctctc cgggtttcat actgctcgga tatacgcttg tgatccacaa 3307861 aatcttcatg acaaacgtcc ttttcttagt agtttgcttt tcgtttgagg gtacgctttt 3307921 accaaaagaa agagatagca cagcgcccca gccgcaactg aaatggccag ccgcatttct 3307981 gcctgcatac tgaagtgttc ggtactgagg cttacaccaa acgcgatgat gcccatcgcc 3308041 gcagtaatca gaaatggctt cataatcgac tggaaataag ctgaaaggtt aagcttgatg 3308101 acatatgcca aaagccagcg cccaatcagg aaattaacaa cgctgataat ggcatacacc 3308161 catgcgactg tcagcaggct tcccgtctgt acagctgcaa acagtgataa tccgtacagc 3308221 agcagcacgc cggaatccca ataaaacgct aagtcagctc ttcctttagc cagcaacaca 3308281 gatccatttg gattcatgag cactcttagt attccgacaa tcgcaagaac atttaggatc 3308341 ggaacagcag caagccattt ttctccgaaa accgctgtga taaaggcgtc tgacacagac 3308401 acgagcccga ttaacagcgg aaacgaaaca agcgccagca tttttgtcat attcagaaag 3308461 ccttctctga tcacgctgtt ttcatatttg ttttttgcga aaatagggaa tgccacccgt 3308521 gtgacaatcg gattgatctt caaaaccgga atggtgacaa tctgataagc gaggttataa 3308581 atccccaatg cttcagcacc aataaaccgg ccgatcaaaa tcatgtcgat atttgctccc 3308641 agcctgttca caagacggga tgaaagctga aaggctccaa aagaaaagaa atccttcatg 3308701 cctctcaaat caaaaacaaa agcaggatgc cacttttttc ggtatacagc ccaatataaa 3308761 atccctttac tggactgcag caggacttga gaaatcacgt acgccaaaat cgcatccatc 3308821 ataaaaaccg ctatcgctaa atatccgaat gacaatacat ttgaaaaaat ctctattttg 3308881 cttaacgtat taaaatgcag ctgcttttgc agcatatact gatattgctg tccaattggc 3308941 gcgatcaaaa acataatcgc cagaatccga accagaaaca ccagctcttc tctttgataa 3309001 aatcccgcaa tgacaggact gctcacatat aaaagaacaa acagcaaaac gcccgtcata 3309061 atgttaagcc aatacaatgt tgacagctgg cgctccgtcg cgtcgtctct ctgaattaat 3309121 gctgcgccaa aacccatatc gagcacaatc tgggcgaaaa ctgtaaccgt tgtgatcatg 3309181 ccgacaagcc caaattctgt taaggtcatc atatttccaa gcagggcaaa ctgaacaatt 3309241 tgtatgattg taatacacat ggttgaaata cttgtccact ttgcaccgct catgatttgt 3309301 tttgtaatac ttggcatcat attccctact tctttttaag ctcagattga tggtgaataa 3309361 tggaatcccg ttttatcttg caccatcacc cgtccaaact actttacaag tttttaacat 3309421 aatttttaat tctaaagtga aagtcagatt gcgaatgtaa tataaatcaa atatcagctt 3309481 ttccttcggc gtcatatcgt aaccgccgtt cacctgagcc cagacgctgt gtaaagcctg 3309541 gaatctcatt ctggaatttt tccgtaaata cgggccgttc cggacgaggg ccaatcatac 3309601 tcatatcgcc tttcagcaca ttaaacagct gaggaagctc gtcaattctc gttcttctga 3309661 taaaagctcc gatccttgtc acccgcggat cttgcttctg tgcccaaacc gccccagact 3309721 tctcggcatc tattttcatg gaacgaagct tataaagctt aaatggcttc ccgcctttcc 3309781 ctacgcgttc ctgcgtataa atggcaggcc ccggcgtctc caaacaaatc aaaattgaaa 3309841 ataccgcaat cattggcagc gcaatcgcca atccaatgag cgcaaaccaa atatccatta 3309901 cgcgctttat tgccaaataa cgagccgtct tttcagataa tgtaaaagaa tgtatttgtt 3309961 gaactgagaa ttcacgactc acattcatgc ttttctctgc actcactgac acacacctca 3310021 cgatttgttt gggatgttat gatgacctat gccagtcagt ttagcagacg gatgttaatt 3310081 ggatgtaaat ggtatgttaa gaagtgtgaa ttacgtgttt tttctgataa atgttgttaa 3310141 tactctttta ctattttata tacaagtcct atttgtttta atcatttcat ataaaaaaga 3310201 gacaaatctg tgattagatt tgtctctttc gattatctgt aataagatac tgtgccgtca 3310261 tgaatagctt gtgcagcttt atctttataa accgcttgct tcaatttact tgcatctgat 3310321 gcattagtga taaaggcagt ttcaactaaa acactcggca ttttagaata tttaataaca 3310381 tagaaagcag ctgtttttac tccccggtct ctcgttccaa gattagccgc taactttggt 3310441 tgaatttgtt cagccagtct cttgctattt gcagcttgat atgttgtatc gtagtacgtc 3310501 tcacttccat ttggtgatga gctatcatta gcatttgcat gtatactgag aaataaatct 3310561 gcttgtgcag aagctgcttt atttactctc tcctgtaaag aataaaaagt atcattagat 3310621 cttgacagta ctggaagagc acctgaagca tttagctttg tattgactct tttcgctata 3310681 tcaaggttga cttctttctc aaggagtcca ttgccgattg ctcctgaatc ttgatcaccg 3310741 tgacccggat caataaagat tgtttcacct acaactggat tctttagctg attagcaacc 3310801 tttgtgctta cggcaggagt gtttccgata atcataaagt ttgacatgtt tttacttcca 3310861 ataattttac gggctcctgt agataaattt tcaccatttg taagaataag agattgcttc 3310921 ttcttagctg ccagtgtagc tcctgcaata gagtcagggt agctgaatcc attgcttaca 3310981 tatacggtgc ttgttgataa attaagtttt tgtacgatat ttgcagcaag ctcatatctg 3311041 tttgaaccgc taattcttgt aggagaaggt aacttgttgt ataccgtatt gctgatactt 3311101 ccagtgcctc ctacaacaac ggtactcgaa attcccttat cttttatcac agacgtagtc 3311161 gcactattta tagatgtttt atttgtaaaa agaattggat acccgttttt cgctgcataa 3311221 gggatgacgg ccggagcgtc tgcatataag aagccgttca aaataacagc ttttgaagtc 3311281 gcacccatcg cttttgccac ccgtgcagcc gtatcataac ggttgcttcc tgcaattcgt 3311341 ttaatactta tccccaagct tttaatctgg ttagcagtgt tagaagaaac agcaggtgtt 3311401 ccgcctacaa taattacatt tttagtctgc atctctttca atcttgtttt cgtttcatat 3311461 gaaagcttat cagaattagt gtaaagcaat ggcgcattct tctggtaagc aagaggtgct 3311521 gctgaaatag catctgcata ggaactccca ccaacaatta cagctgtact tgctgttgaa 3311581 tacatttgct ttgatatttg tacagcagtg ccgtatctat tgcttccccc aactcttttc 3311641 actgagttat cggccaaagc tgttggcaca aaaagtatga gccccagaaa acacattgtt 3311701 aggactttta tataagaacg caattgattt cctccttaaa tggcgttata tcctaaaata 3311761 atcaataact tgtcagagtt gtacctggat agtaaaattt caaaattgaa ctatatgaat 3311821 ctccagcttc tgctcttgct tttgctccat attgactcat tccgatcccg tgaccatatc 3311881 ctttaccgct gattgtgtac tttgaagtat ctttttttac agtcacataa gtacttttaa 3311941 atacagtcgc tccaatcatt gttcttaact cacttgttgg tacactaatg gttgtaattt 3312001 tgctcaagtt ataggagcca gtactgcttt taacaaaata cttcactttc atcgatgctg 3312061 tttttgcacg ctgcccttgt gtcgttccac taaagcttaa atcgtcaata cttgcaattt 3312121 tgacagaatc agcgcttgtt tctttatttt tcaagatcca gttcttaact ccggaaagtc 3312181 ttgcagaatc agtttcagtc gctgaagacc accaagaaga aggcttcgtt aagtccaaag 3312241 atttcgtatc tagctgttgt tttgacaaag taagcgtcca gcctatttga ggatcctttg 3312301 tatctttttt tgcaatcaag taaggtacac ttgacgacca cacttcatta ctagcttctg 3312361 tgtaaccacc attactggaa gaataagctg cagttataag agatccatta tatttcagaa 3312421 ctttcccctt cgtttgctct accgctttat tggtattcga attccaactg tagccaccat 3312481 aaacttgaaa agcggttgta tcaggtacag tagttcctgt ttttgttatt gagtaggttc 3312541 ttgcagcgac agtctgtgct ttaagagcct caagtgacca gctagcaggc atttcattcg 3312601 gaattactcc ttttaagtaa tcctcaaatg gaatattctc atttaccggt cggatatatt 3312661 tagtagactc aatagagaaa ttaaccgtgc caagatactg ctttccatca agactaattc 3312721 tgtttgaagt agaatagttt tctggtttaa ttcttaggga gtttccgtaa gttttgatgt 3312781 tttcaaggtt taattttccg ctgttgattt ttagattata ggtgccaccg tcagctaaat 3312841 aaaattcatc agcaagtgaa ttctcaactt cagcagaaat tgaactggta cttccaataa 3312901 agtcgtatgc atatgtggct ttatctttcg ttatactttt agccgcagcc ggaacgctat 3312961 cttgtttaac aaataaaatt tggctgtttt tcttcgaggc aagcgaagcg cctatcaata 3313021 cgtctgcata ttttgtcccg ttcgtcatta cgactttatc agccttcaac tttagttgct 3313081 taattatatt tgccgtaagt tcatatctgg ttgatccagg aatcctttgc acagttgaag 3313141 tttttttaat ttggttttct acactatcac tgacgctaaa tgaactgcct ataatgatga 3313201 cttgttttgg caaatcataa tccggaagct tgtctttctc tgtaagcaaa atagggtatc 3313261 cgtgtgctgc tgcatatgga gcaatggcta aagcgtcttg aaatactctt ccggttacaa 3313321 cgatcgcttt atcatagctg cccatttgct ttgcaatatt ttctgataag acatatctat 3313381 tttttccgct tatccttttc acagcgccat atgatttcag cttgttttct acgtcttttg 3313441 aaatgcttcg cgctccccca atgattaaaa tattatcagg gttaaactta gcaatttgtc 3313501 tttcagtagt ttttgttaac gtgtcaggct gagtaaataa aactggtgcg ttcagttttt 3313561 tcgccaatgg aataacaggc aatgcatcaa taaaaatatc tcggttcacc aatatcactg 3313621 tattaggatt tttccactgg ctgttggatg caagagtcgc agtttcgtat cgtgaagcgc 3313681 ctgcaaaacg atccgtaaca gcaacattat ctccagttac tttataaaat cctgttggcg 3313741 atagactgat gctagattta tttccaatat aatttaacaa tttaactgag atgtttgagt 3313801 ctgctgcaaa agaaactgat ggaatcaata ataagattgc agcaagtgaa cacactatca 3313861 attgtttgca agatttcaaa atttcaggtt cctccctata tcttagttgg cacgttcaat 3313921 atcttttaac agaagctgac cctcatcatt tttttcatat gtaatcgtga ccttatctcc 3313981 actgttaaac ttatcaagat cacttgtcga ttcttcagtg atatcaagac taaccggctc 3314041 attatctact gttacttcta ttgtatgagt atcagctaac cctacataag taccttcttt 3314101 tgtttcaatg ttactgtctg gcgatacatc ttcaccttga ctcttttgac tattaacccc 3314161 gcaacccgaa agaagcaata taaagaacag taaagcaata aattttttca tttttttcac 3314221 ctcattatat tttatcgtca acctatttta tattttaaag aaaaattaag aaacaatgaa 3314281 actttttttt ataaaaaacg actattttag gatttcattc ttgtattaaa tagagttgta 3314341 tttattggaa atttaactca taatgaaagt aatttaacag acgaggtgca aaggatgaga 3314401 aacgaacgca gaaaaaagaa aaaaacttta ttactgacaa ttttaacgat aatcggactt 3314461 cttgtactcg gaactggcgg ctatgcatac tacttatggc ataaagcagc ttcaaccgtg 3314521 gcaagtattc atgaaagcat tgataaatct aaaaagaggg ataaagaggt cagtatcaat 3314581 aaaaaagatc ctttttccgt cttaatcatg ggtgtggatg aacgcgacgg cgataagggc 3314641 cgtgccgata cgctcattta tatgaccgtt aacccaaaaa cgaatacaac cgacatggtc 3314701 agcattccgc gtgacacgta tacaaaaatt atcggaaaag gcacaatgga taaaatcaac 3314761 cattcatacg ctttcggcgg cacacagatg acggtagaca ctgttgagaa cttcctcgat 3314821 gttccggttg attattttgt gaaagtgaac atggaaagct ttagagacgt tgttgataca 3314881 cttggcggca ttacagttaa cagcacattc gcgttcagtt atgacggtta ttcgttcggc 3314941 aaaggagaaa tcacgctgaa cggaaaagaa gcgctcgctt atacccggat gagaaaagaa 3315001 gatccgagag gcgacttcgg acgccaggac cgccagcgcc aagtcatcca aggtattatt 3315061 aataaaggcg ctaatatttc ttccatcacg aaattcggag atatgtttaa agttgttgaa 3315121 aataatgtga aaacgaactt gaccttcgat aacatgtggg atatccagtc cgattacaaa 3315181 ggtgcgcgga aacatattaa acagcacgaa ctaaaaggta caggcacgaa aatcaatgga 3315241 atttactact accaagctga tgaaagcgcc ctttccgata ttacaaaaga gctgaaggaa 3315301 agcctcgaaa agtaaaacaa aaagaagctt cgcacaatgt gcaaagcttc ttttttattt 3315361 gcctgtaaat gaatccggtt gttcttttcg atacccgtaa tgaaacagca attcttccac 3315421 aatccggcgg gaagcctctc catctccata cggattagaa gcctgggaca ttttcttgta 3315481 ctcatcagga tcagttaaca gctgttttgc aagctgataa atgttttcct catccgtacc 3315541 tgcaagtttc agcgttcccg cttccactcc ttcaggccgt tccgtcgtat cacgcagaac 3315601 aagaaccggt ttcccgagag atggggcttc ctcctgcacg ccgcccgaat cggtcaatat 3315661 aaaatgcgat ttcgctgcaa agttatggaa atcgatcacc tctaaaggtt caatcagatg 3315721 cactctgtca gaatcaccaa aatgcttatg agccgcttcc cggacaacag gattcaggtg 3315781 cacagggtaa acgacttgta catcttcaaa ttcccctaca attctgcgga tggccttaaa 3315841 catgttttcc attggctcac ccaaattttc ccggcggtga gcggtcaaga gaatcatttt 3315901 atcctcaccc acctgatcga gaacaggatg tgagtaacca tccctaaccg ttgtgttgag 3315961 tgcgtcaatc gctgtattgc ccgttacaaa aatagagtcg gcctttttgt tttcttttaa 3316021 taaattgtct ttcgcctggc ctgtcggagc aaaatgcaaa tcagcaatcg cccctgtcat 3316081 ctgtcgattg agctcttccg gaaacgggga atacttattc cctgtacgga gccccgcctc 3316141 cacatgaccg acagcaattt gatggtaaaa agcggctagg cttccggcaa acgtcgtcgt 3316201 cgtatcacca tggacaagca caatatcggg tttgatatct ttaaacaact catccaatct 3316261 tacaagtgcg ttagacgtaa tctctgccag tgtctgccgc tccttcataa tgttcaaatc 3316321 gaagtcaggc ttgatgtgaa acgcatctaa cacctgatcg agcatctgtc tgtgctgtgc 3316381 agttaccgtt acataggaat ctatttcagg atattttttc aattcaagca caagcggtgc 3316441 catcttgatc gcttcaggcc tggtcccgaa aacggtcatc acttttagtt ttttcatatt 3316501 tgtcacctgg ttttctgcta tagtaaataa attcatacta catattctac atgaaaatgc 3316561 atcattttaa atcatttcat tcttgattca aataaaatga tataagtttt aatattaagg 3316621 ataaagcttg tttaaaaatg gtttatccga tatcataaaa atgtgtaaaa acatattgaa 3316681 aagggtaaat agagaatagt ttaaccataa attttttcga tcataaggaa ggtgcctttt 3316741 aaatgaaaaa agtacgtaaa gccataattc cagcagcagg cttaggaaca cgttttcttc 3316801 cggctacgaa agcaatgccg aaagaaatgc ttcctatcgt tgataaacct accattcaat 3316861 acataattga agaagctgtt gaagccggta ttgaagatat tattatcgta acaggaaaaa 3316921 gcaagcgtgc gattgaggat cattttgatt actctcctga gcttgaaaga aacctagaag 3316981 aaaaaggaaa aactgagctg cttgaaaaag tgaaaaaggc ttctaacctg gctgacattc 3317041 actatatccg ccaaaaagaa cctaaaggtc tcggacatgc tgtctggtgc gcacgcaact 3317101 ttatcggcga tgagccgttt gcggtactgc ttggtgacga tattgttcag gctgaaactc 3317161 cagggttgcg ccaattaatg gatgaatatg aaaaaacact ttcttctatt atcggtgttc 3317221 agcaggtgcc cgaagaagaa acacaccgct acggcattat tgacccgctg acaagtgaag 3317281 gccgccgtta tcaggtgaaa aacttcgttg aaaaaccgcc taaaggcaca gcaccttcta 3317341 atcttgccat cttaggccgt tacgtattca cgcctgagat cttcatgtat ttagaagagc 3317401 agcaggttgg cgccggcgga gaaattcagc tcacagacgc cattcaaaag ctgaatgaaa 3317461 ttcaaagagt gtttgcttac gattttgaag gcaagcgtta tgatgttggt gaaaagctcg 3317521 gctttatcac aacaactctt gaatttgcga tgcaggataa agagcttcgc gatcagctcg 3317581 ttccatttat ggaaggttta ctaaacaaag aagaaatcta aacaaaaagg ctattggaca 3317641 ttcatccaat agcctttttt tatttcaaca tcaaagtcaa tgtatgctct tcattatcaa 3317701 ctgcgaagac ctgatcaacg gcctgccgca aaaattaata atcccagaca aacacactga 3317761 ttgtagagtt aaacaaacta aatgaaaaca taaatacaaa catgcagatt aaatagtaaa 3317821 tatcttgtat tcaatgcaag ctaagtaaac accacttgct aaaagaacaa tgactaaaca 3317881 accagcatta caaaataatt aaataaattt gaagcaatta caacagaagg cagtgaactg 3317941 tcggaaagtt cattttggct accatattaa tccctttaac tacgctgttg gatttatcaa 3318001 gaattgtcgg gctaatagaa aaccacggaa tcaaaccagc cagcattcaa acgataaaag 3318061 gcacttctcc gatacctgtt atgaccagct tactgttgcg catcccaaat acaaaccagt 3318121 acgccatcat tagaataagg ggatttaaaa cctgccataa tacaccaaaa taattgattt 3318181 tttggatctt tcggttaaag aaatttaaaa gtaccagtga atattgtaac aaatgttgag 3318241 tttttttcac ttttaaaaag taaagagaag tctcgcagaa cttctcccaa catttgaagt 3318301 gtcaatataa aacaaaccaa cctcatttag caactttatt attatctaat tccaaaatag 3318361 cattataaat acgattccta ttatttttat cagtatatgc aaaaaagtta tctactcttt 3318421 ttctatactt atcttccata cgactattgt ttttcatata atagataact ttatccacta 3318481 agctattatg attttctaat acatcaccaa accccatttt tttataatca taataatcaa 3318541 gtttaaaatg gtatgacttt tcgtattgat aataaataac aggttttttc tcatatgcaa 3318601 aatcaaacgc aacagatgaa aaatcagtaa tcattatatt agaagaatta aatagcattt 3318661 gatagctgct gttatagtcg gcaaactcca cataatcatg cttttcaaag tctacaatct 3318721 gttgctgaat atctgggtga ggaaaaaaag ttattttata attatttttc ttagcaaatt 3318781 cgattagccg ttcatcatta atcaaagcat tatacctaga aaaatattca ctatctttaa 3318841 atttcgggtt gtacggtctt actccttttg cctgatcttt cggtaataca atatcttttc 3318901 tccaagtcgg cattattaga agttgctttt ctccctcact cttcttaaga ttatcgtatc 3318961 tcggaaatcc acccaacaaa atattctctt ttttatagtt gtaattccct ttcacaatag 3319021 accgatattc aggtttggca gaagtgacta ataatttgat attcttgttg tatttgttta 3319081 accattcaga atgatctgcc attgttattc cgtgctgtaa aaagataaac tcaaagttaa 3319141 ataaatctct aaaataaatc tccatattaa aaaatggatt tacaacccat atatctgcat 3319201 gtgtcgatat tactttggaa gaggataagg ttaaaatttt atgtctaaaa gatctgtatg 3319261 gtatgacctt tccatatttt ttgattctgt cgtaatcctt gctatctttt tttattataa 3319321 agtatttttt taccccatca ttcttgttga ttgcatattt aaagaggtgc tcggcattat 3319381 catcagcttt gtcttgtctg tctatgaata accatactgg ttttctatta aaaatagtga 3319441 aaacatggtg taccattctt gccatcagtg ccttcttaat cgctgatttt cgtttttttg 3319501 atttttcccc tgatttatgt agggatttta agaaacgaaa ctcttttata aatctatttt 3319561 taaaattgtt ttttttgaac attaattttt tataattata ataaaaaata taatcttttt 3319621 tagccacata agtattatat aaatcgtttg acaaacctga atacttgaaa aaacgaagtt 3319681 ttgtcaactt ccttttttta cccttagtta taaaaaactc aatatgatga ttatctgcta 3319741 gatgaccttt gggaatatct attgaaaaac cgggatattt ttttattact tctcctaaac 3319801 ttatataatc attatgctgt ctttttatat tctttgcttt tatttttgtt tcgccaattt 3319861 tagcataaaa cttaaaacct ttagaattaa acagcgagct ccaaaagcct tctatgtgaa 3319921 tggaatcctc attttcttct aaaatttcaa tagttaaagt ttgatccgat aatttcgaaa 3319981 caattttacc ttctctgtat aaataataat cctgttcagt ttctctttca tatacatacc 3320041 tactataatt ttcaccgtgc tttattttta aagcatgata taaatagaaa tggctgacac 3320101 tttttgtttc aatgatgaca tcgtcgtcaa tatacgacaa tacttctcga atcaatgtta 3320161 aaaattcact gtattcattt tcgtctaaag gtgtttcact gatatcctta atcaataatt 3320221 tccacttcaa atcatgcata accatatatt gaagaaataa aggtattttc tgttcatgat 3320281 tttttataat atcgattaaa ttctttgaga aagtgataag tgaatggtta aaccaattct 3320341 tatttgcttt agcagtctgc atggcagatg atccatcttc tctaactcta taatggtatt 3320401 ttgcctcttt aaccagacca tactttttct tttgcgatat gattaaatta actagtttgg 3320461 catcttcacc tattttacaa ttttcatcaa acctgatatt tttcaaggca tcttttttta 3320521 taaatgtaga acaacaatga gttaatatat gatgcggttc tttttctaca tccaaaattc 3320581 ttgtagaaga aaacttatta tttagattat gttctccagt tcttccttct gcaaaaaaaa 3320641 tagggattgc tacaatatca atttcattct tatgttcgtc aaagaagttt aaaacatttt 3320701 cgaatgttcc ttctgaaact aaatcatccg gatccaaaaa ttgaatatat ctaccttcag 3320761 catactttaa accataattt cgagcactgc tcactccgcc attctgtttc tttgcataga 3320821 caatgttatt gggatatttc tgagcatatt ctttacaaat gatttcactt ttatcggggc 3320881 tatcatcatt caccagtatt aactgaatat tctcaaaacc aatagtttgg ttaatgatac 3320941 tttctatagc ttcagtgaga tacaactcaa cattataaat cggcattata acactgaaat 3321001 catagttaaa acttttttcg ttcataaaag attactccta acataatgtt tatatgaata 3321061 agaattcggg taaataaaat taagaaacaa gagagtacta atttttgcaa aacaatttta 3321121 atttagtaaa atgtatgaaa agcattcctt accttttttt aaaaaccctt gtaagcaaac 3321181 ttttaaaaat gttcacatgg ttaagttcta aagaatcatt tggtgttttt agtacaaagt 3321241 caaatgcaaa ggcccaaatc ggtatttcga caacaaaacc agcatatcta aaatctctta 3321301 atttatatcc ccatacttca attgtttttt tcagttcttt tcgtttgcat ttttttaatc 3321361 ttttaaaata ttttatatat attctgtcat tttctttcat ctcataatac tggttaataa 3321421 agtgccctgt taattcaagt ctaagccctt ttatttttgc cgaagtaaca gtacatgaac 3321481 tatgcagtac tctttctttt tttatatttt caagagcttc tgtattttct tttaataagt 3321541 gaaacataaa ttctttatag tacatcggca tatcttgttc ttttataaat tgcgggtcaa 3321601 taaattttaa aactttaata aaatcatcaa caaaaactct ttgttcttgt tgatctaaaa 3321661 cagacttata aacatctcta tagttcggat ataaaaacag ttttatatga tatacaatta 3321721 aaaattgcaa ataaggcaaa actatatcat atttgttgaa tgaatccatc aacaaagtca 3321781 tgtaacattc attcaacaaa tatgtgtacc tttttttgtt aaaccatgaa cgatcaacta 3321841 aagaatcctg ttctttccgt tttctataaa aatactttcc ttctgcaact gctccgtatc 3321901 ttttttcttt cagtaataac tggttaaaaa agatagcgtc ttcccaaaac tttatagatt 3321961 catcaaaaag gacggtacta gttagtgtat gtcttctgta aaaagtgccg ccaatataaa 3322021 aatgaatagc tttataatcg ttgagaatat ttataactct tgttcctttt tcaaatctat 3322081 tatttaattt atgtccccct tctttttcac ctgtgtaata aacaggtaat accgcaatat 3322141 ttacatgttc ggaatcacaa aaaaaatcat aaacactttg cagcgcattt tgagagaatg 3322201 catcgtcaga atcaagaaaa ccaataaatt tagatctttc gcttacattt gataatccac 3322261 aatttcttgc agcagaaggt ccagagtttt caattttcat gattttaata ttattaggat 3322321 atagattttt aaaggattca caaatttgag gactgctgtc aacactacca tcatctatta 3322381 atatcagttc tatattttcc ttaaatccaa ttgactggtt aaggacactc tctattgaat 3322441 atcttaaata attttcagaa ttatatattg gtataattat agaaaacatg tttgtacctc 3322501 tttatttaga agttaaagga tcgtttcaat tactctttta gaagccttgc ctcttctaaa 3322561 ttacaaaatt tattataaaa atcctcatag ttatgatcta tataaggatt atgtaacaac 3322621 tcttttaccg tatctataag ttcttcactt gtttgaagca agtttcctgg cgttttttgc 3322681 tgaaaattaa agtaaaaacc tctgatacag tctctataag ccgggagatc atacacaaaa 3322741 aatacaaggt ttttttaaaa attcatatta tcaaaaaaga cagaagaata atccataatc 3322801 aataaatcac taattaaata taaatctcga atatctttat ttaaagaaac atcgttcaca 3322861 aaatatttat atttccctaa ttaaattgtt ctgaaactgg ataataccat tcttacaaga 3322921 ataaccatag agtctccaag gttccctctt catttcctct aatcaaatta aagttaaatt 3322981 tatactggcc agctttctta aaattcatta tcccgcaaag ttggtgcata taaaattatt 3323041 tttctttaat tccttatttg ataatgtaga attggtaggg gattgtagct aaactgtttc 3323101 cagaatagct ttcaaataaa attaatttat tgtttcttgg cagaaggaca aaaattttaa 3323161 acaaaactga ataaactcta actagtaaac ttctgcaatt ggttataata aaaatttcat 3323221 cagtgaactc cttaaagagt gaagattaat atttacgcaa acaagaaaaa aagaagcaac 3323281 tgaatttact tcaagcctct tttagttagt gcttctataa actagccata tcttttctga 3323341 tttgggtagt tgaaatgcct gctattcttg taaggtaaat ggcctcatag tattcctttg 3323401 tagacaatcg tacgattaag taatcccagg ttcttttgct ctttccagta gcttcatatg 3323461 tccatagtga aataaatcaa acattccgta cgtatcactt tcttcattag ataacatcac 3323521 cttccaacct tttccaactt agaaaaaaca aaaatcctta actgattgtt tatcatttcg 3323581 acatattttt tacgttccat taataataaa caataatagc atatgttcct ataaaagtta 3323641 aggctcttta aaaatgtaaa tcatcagcac tttttgacaa tatcgttgca ttgatgtgta 3323701 ttttttacag atctgatatc ttatctatac tcattacaac aagttttcta ttccggaaga 3323761 gtcaattctt tttgtcgcgt tttcaagtgt aatgattttc tttctgctgc gtcatttatt 3323821 ttgtacgccc tcctcatatt acttcatcgt caaaacgtga aggaattgta atacgtagtt 3323881 cctaaaaatt ttcgtggtaa aatttagtga agtctttatc aggctaaggg actttatcta 3323941 aactacgaat tacatatgga gatatataga tgaaaaggag ggttgatatg atataaacga 3324001 aaatcaatta gataaaggaa aaactgaaca cttctgaaaa aagtgataag tttctttcac 3324061 tatatcctcc aaaaagaacc taaaggtctt ggacatgctg tctggttcgc gcctaacttt 3324121 atcggcgatg agccgtttgc gtttctgctt ggagacgata ttgttcaggc tgacacacca 3324181 gggttgcgcc aattaacgga tgaatatgaa agaacacttt cttctattat cggtgttcag 3324241 caagtgcctg aagatgaaac acactgttat ggcatcatcg ccccgctgac aagtgaaggc 3324301 cgccgttatc aggtgaaaaa cttcattgaa aaaccgccta aagacacagc accttctaat 3324361 cttgccatct taggccgtta cgtattcacg cctgagattt tcatgtattt agaggagcag 3324421 caggttggcg ccggcggaga aattcagctt acagacgcca ttcaaaaact gaatgaaatt 3324481 caaagagtgt ttgcttacga ttttgaaggc aagcgttatg atgttggtga aaagctcggc 3324541 ttcatcacaa caactcttga atttgcgatg caggataaag agcttcgcga tcagctcgtt 3324601 ccatttatgg aaggtttact aaacaaagaa gaaatctaaa caaaaaggct attggacatt 3324661 catccaatag ccttttttta tttcaacatc aaagtcagtg tatgctcttc attatcaact 3324721 gcaaaaacct gatcatctgt attcacaaga aaacgcttct tgctgctgtc atacaataca 3324781 tcgctatcac ttaaggatag tgacgccggg ttgataggag aaatgttatg aaaaataagc 3324841 tctgttgctt tatcattctc cagtacataa ctgatttttt cataatcaaa attcagcgtt 3324901 tttctgccgt cagccttatt tccttcagta taaccattca atttcgattg aatgctggtg 3324961 ctgctgtctc ctaggaattt cagaaagtat tcataggaag atgctgcgtt ttgcgagaca 3325021 taagacgtaa atgcagtggc atgcaattca gcgtgtttca tgttagttgc aacagcgctc 3325081 tgtttcacat aataagagtg cccgtcaaac tttattttcg ctgcttgttt gccttttgca 3325141 gctaccgtta cttttgtacc gaatggcagt gtaacgtcag ccttctgttt caaaccctga 3325201 tccttataag cagccgcttt ttcatttgct ataaaccctt gcttattgat tgcagttaag 3325261 cgttcctctg acttgccctt tgcatcgcca tgatggttct tcacttcatt ttgcggaata 3325321 gcgccaaacg aagcaattgt acgaagcggg gcattaaaga acatcgttcc cgccatgaag 3325381 acagtcagaa tagacaaaat agcaatttga atggcattgg ccagtgattt cggctttttc 3325441 ttctttttgc ggaaacgggc aaacgcttca ggatcttctt tcttcctctc ttctgtctgc 3325501 tcttttttat atgtctcttt ttcttttttc gatagcttat taaaccagtc aataaacgct 3325561 ttgtactctt tcacaaccgt ttttgtttca tcaaacatac gaagctcgcc atagtgcatc 3325621 caagcaacac ggtcacacat cttttcaatc tgaccgattg agtggctgac aaagaaaatc 3325681 gtttttcctt gctttttaaa ctcatttatt ctgtctacac acttctgata aaacgtttgg 3325741 tcccccacag aaagagcttc gtcaataatt aaaatgtcag gatcaatatg cacggagatc 3325801 gcgaaaccga gacgcgactt catcccgctg gaatagtttt taaccggctg attaataaaa 3325861 tcgccaatct cggcaaattc aacgatgctg tcatacatat catcaatttc tttattggtt 3325921 aaccccatca tcaaacactt gagccggaca ttgtcccggc ccgttaattg gttattcaaa 3325981 ccggcagcaa tcgcaatcag cgacggctgg ccgttcattt caatttcacc gctggtcggc 3326041 ggaataattt tagccagcag gttagacatg gtcgattttc ctgacccgtt tattcctaca 3326101 aagccgattg tctccccttc atacacgtca aaggagacat tccgcacagc aaaaaaacca 3326161 ttatccttag ccggaaaaaa caatccttta atcttgtccg attgtttttt atacaaatga 3326221 tactgctttg aaacatttcg aaacgaaact tttagtttca tcgtaaaatc tccttacgta 3326281 ttaaagaaag tcaacaaact tgtctctgaa tttcatatgc aggatagaac ctactaacaa 3326341 taaaaggaat gtgaacaacc aaaagtacag cgtgtacttc atgtcatgga aaaaccatgc 3326401 tccatctaag aagctgttcc ggaatccttc aataatatag aatagtggat tcaacttcag 3326461 aacaggcact aattcggggt ggctttgacc gagtttcgca ttaacatccc aaaaaattgg 3326521 caacaagaaa aacaaaagtc ttgttacggc ctgcagcaaa aattgataat ctctaatcag 3326581 cacactgatc gttgagttaa acaaactaaa cgaaaacata aaagcaatca tacagatgaa 3326641 gtaataaata tattgtaacc aatgcacact cgggaacaca ccattaacta ggagtacaat 3326701 gatataaatc accatcatga tcatataact aaataagtta gatgcaattg ccacggacgg 3326761 tagagaacta atcgggaagt tcattttagc caccatatta atgcgcttaa atacactatt 3326821 tgatccatca agtatagttg gactgatgaa aaaccatggg attaatcctg ccagcatcca 3326881 aataataaaa ggcacttcgc ccgctccggt tgtcacagga ccgccctttc taatccccat 3326941 accaaatacg aaccagtagg ccagcatttg gataagcgga tttaagaact gccataagac 3327001 acctaaataa ttcatttgat atttagactt ggtttcataa gccgccaatc ttaaaattaa 3327061 aggaaatgac gttatttgct ctctgagtat acgcaacaaa tcattcattt tttatcttcc 3327121 ttagacttaa ttgtttttgg gaatctttct gtttaaaatt tgaaagcacc gctgattatt 3327181 gtaacagatc ctgcattttt tttcacttct caacaagtat ctaaaaagct gccgaaaaat 3327241 cgacagctat acattttata aaataaccta aattattcag ctttaaatac agtattaaca 3327301 accttttcag atgaacgtcc tgactctaaa tagcaaaact tatcatagaa aggaccaaaa 3327361 gaaaccggaa gcttataatc aggcgatgag atctgcttga tagcctcaat cgtttcttca 3327421 gtagttttta ccaaaggacc aggagcttct ttttcaaaat caaagtagaa accacgcaac 3327481 ttgtcccggt aggtttcgat gtcagggaca aagaatagca ttggccgttt taaatttgca 3327541 aaatcaaaga atactgaaga ataatcagta atcagcaaat cagaaaccat atacaattct 3327601 cgaatatcct cataagcaga aaaatcatat gcaaatcctt caaaaggacc taaatcaaaa 3327661 ttctcagcta ccagataatg cattcttaag attacaatat attcatttcc aagttcttgt 3327721 ctaagttgat gcaaatctaa atcgagatcg aacttataac gcccttttgc atagaactga 3327781 tcatctctcc atgtaggggc atataaaata acctttttat cacgaggaat atttaaccta 3327841 ctctttatca atgatattgt ttcctcatta ttatcattat gaagaaaatc atttctagga 3327901 tatccagatt caatcattgt cttgttaaac tgaaacgccc gtgtaaagat ctcagttgaa 3327961 taaccatttg gggaaatcaa gtaatcccaa ttagaagctt ccttgataaa attcctttta 3328021 tattttttgg tgtttgtacc aggcatatgg acttcttcca tatccattgc aagtcttttt 3328081 aaaggtgtgc catgccatgt ttgtaaatat gttgtatgac taggtttcgg aatccataat 3328141 ggaagccggc tgttaacaac ccaatactca gctcttgcca tagcgaagag ccattttaat 3328201 gagaggcgat taatgtaagg aattcccttt tcatcaaaag gcgctgaata ttgtttattt 3328261 acactccaat acattttata ctcagggtgg ttttcccgca tatattcgta aatcgctctc 3328321 ggattacaac tgtattgttt cccattaaaa ctttcaaaaa tgactgtttt ccttttaact 3328381 ggcattctgc tagccatcat gaatagagat ttgtatgttt tagtgattaa cttgtttctc 3328441 atttttgtga tcttttttat ttttgatact aatctcttct tctttccttt aataaagtat 3328501 ttcatccttg ttttcaggct atagtcgttt actctgatac ctagagtctg ctttttcttt 3328561 ttcttaaaga cttcataacg aactggtgcg ttgtttgttt taataatact tactaatcct 3328621 tttaatttgt tttttcgatc tcctaaaaca agagcagtgc tgttgaactg aatatccgtt 3328681 ccttcatcgt cattgcatat atactccata aaaagacgat aaacataacg tttttcattt 3328741 gagaaaggaa tttctttcaa aggcactttc acttcaaaat catacagttc cggaacaaaa 3328801 ccatctgctc tcatgttttc caggccatgt gtttttcttt ctagcttgat tggaaatttt 3328861 tcctcaatag gtgtttctcc accctttttt aaaataaggt tcaagttttt tatccgatat 3328921 tgattttcgg aactcaggta ccccgcataa cctgttatgc ttatttcttc agagctaatc 3328981 tcgatttgat caaatctgat gattttggcc tctcttttca ccttaataga aaagttgcct 3329041 ttatcagttg tataaggtaa aatcaaaagt tctgtggttt gatcgacatg aaaggcgcgc 3329101 tcaattgaat ttacttcagc agaaagacgc ttcaagagtg gttcctgctc cgcatcttca 3329161 tatttttttc gaaattcgac ataaaaatca tatgtttgtc ccatttcaac aggcataggc 3329221 aaaacatgag catttatctc agttttatac tctaatgagc cagtgttttg aagcggaaat 3329281 tcagattccg ttcctgaacg tctctctttc agctttaaaa ataactggta atcctctaaa 3329341 aattggtgtt ctgaatcaat tgagattaac aattcaagac ttcctaaatt gtttttcaag 3329401 cttttcaaaa tacatttaat cacagtgttt tcaatcatta cttttttctg ctcctctgta 3329461 taaaagctct ttcctttttg cttcctttta ttagtgtcaa ctactaagga cattaactct 3329521 cttttatttc cgtgaccctc caagagaaat tgcctttaac tgttgtatag ggctctactc 3329581 tatagccatt attagtatct atactgtttc ctgacaattt tgtttcttca ctcgaaagtc 3329641 ttcgcattgt tttaatatgg ccatttgcat tgaaaacaat ataaaaatca ataacttggg 3329701 ttttattagc agctatcttt tcaatattta catctttttc gagatcaatt acaaacagtt 3329761 gatcattttg taagtttgtt gaaataattt cagccttatt ctttctgtcc aagcccacta 3329821 aacgtatttt tttaatatca ttatgatcaa aattctcaat gtcaatttct attttagttt 3329881 tatcaaaatc ctcagtatag gaactaatag aaggatcttt ttttccaacc tttttagaga 3329941 acttctctct ttctattcgc acctcaatca tctgattaag agcaaaagcc caattttcaa 3330001 tatagttggg tcttgaatat ttttcagcca ttttaaaagc ttgttctgaa aatttttgat 3330061 gagtactttc atctttcatc aaagagataa tagcttgacc caatttctct atattatact 3330121 gttcaatgac atatccattt gctccgtcag taactaagct ccttgctccg taatcataat 3330181 cgtatgttac aactggacat ccattgctca gtgcctccat atttgataga ccgaaccctt 3330241 caaaatgaga ggttgaaatg gttagccaag ctttttgaaa ctctgagtca gggttatccg 3330301 tatagccttt caaaaagaca ttgttctgca gtttggtatc ttcaatttct ttttttattt 3330361 tttcgaaatc ttcacccgat ccgaatatat caagttttgc ttcaggaatt tctttcacga 3330421 ctaaactaaa tgcttttact gcatgtatca gatttttcat agatgcaagt cttgaaataa 3330481 tgacagcttt gtatttttca ctcggcacat tcaatacagc gggatcaaga ggcttatcaa 3330541 ttgtatgcgg agtaaagaaa aacgtctctt gttcccctga aatcaattta aaatcttcta 3330601 gctgctcctc agttataaaa aagacagcat ccaaattata catctgacta aatacttctt 3330661 tatagcgacc cttaatttga tatttattgc tgccgtaatg cttgttatga ataattgctc 3330721 cataatagga agaaggtgat tttttcactt taaagacatg tttgtcttgc ggtctgctgt 3330781 ccactaaaaa caacttaggt ttatcatttt gtttttgcag atattctatc caatattgac 3330841 gcagttccga ttcatctttt acttttatct caccctcaag ggagtaccaa ataatatgag 3330901 ataattgaac atctttttct tcattgttcc atacatagag tttgtctaaa tatacttgat 3330961 tttggtcatt aatatattcc tgcagataca tcttgtttag ctgcacatca taatgagtaa 3331021 cgagaactaa gtttccgttc ttcgtatatt cctctctctt tatgagctgg tttttatcat 3331081 tccaatagtc gacgtaccgg atagtttctc catctccgta gtaaactaca gacatttcat 3331141 tgttcttctt accaaacaat ctcaacagag tttttgcaaa tttccccatt ccaacttgct 3331201 tttttatctg gtcaaggcct atcctttctt cgtatgatct tttcccattt gttctaacac 3331261 ttaaaaaatc atcgaataga ttaataacac ttgtgaattt tttatcaatc ttaccgttgc 3331321 tgtacaattc atcaattttt gaagacaact ctaaatcaaa acgaaacgtt aagaaaaagg 3331381 tgttttggtt acactcttct ccaaataatt ttgaacgcaa taataatgat ttcgtcagac 3331441 cgccataatt acttggcagt ccaccagaga taaaataata atccatgtca ggaatttgtt 3331501 ttatattaga ttcactcacc gcatgtaaag acaatttttt actccctttc ggcatctaga 3331561 atatatgatc attgaaattt atatctaccc ggatacttta gtcacaaaaa tcaatgtaag 3331621 catcaaaaag tacttcttat ttcaataaga agtactttaa ttagatattg aaccaatgat 3331681 atcaggatcc taaattataa accagcaatt tcctctttga tctttgttgt agagatgcct 3331741 tctgttcttg ggaggtaaac aacctcacac tgatctttga gaaagtcaaa tttaccttcc 3331801 cagtcatccc ccataacaaa aacatcaata ttatgatcaa taatatcttg ctttttttgc 3331861 tcccaattct tttcaggaat tacttcgtcc acatatcgaa tggtttctaa aattaattta 3331921 cggtgctcat agctgtgata agcttttttt tgcttttgta aattgaattc atccgttgaa 3331981 atagcaacaa ctaaataatc accaagctgc tttgcacgct caagcaattt aatgtgaccc 3332041 caatgcagta aatcaaaagt tccatatgtg ataacttttt tcatttaaag aaacgctcct 3332101 tcctaatgtt aaacactatt aaaaacacta ctgacgttag cgattaaatt ctaaaaacct 3332161 gtttgtattc cttatatcga catatttctc gtatgtcttc actgatcatt aattatagca 3332221 taccgcctaa aaaaggttaa gtactcatga ggagaaaaac attccaaaat atgtaattac 3332281 actcagactc cattggcacc aaggtctgtt gttcattcgt tcattcaatt gtaaaattgg 3332341 aaacatattt aaatttaatg taaagataat gttaatcctt tgttgaagat ttatgttaaa 3332401 atataaggta gcttgatttt gcttttagaa actctcggtt tttaactata taaatagaat 3332461 cttaaaggaa ggaggagcca gacatgcaaa cagagactat tcacaatatt ccttatgtta 3332521 acagtaactt aacatcattt atcgattacc tagagaaaca ttatattgat caaaagattg 3332581 gtgctgtcat ttccacagtc aaccctgaaa ttgcatttgc agctattaaa gatcgggact 3332641 actttgatgt actatcttct tcaaacttca ttttgcctga tgggatcggt gtagtcatga 3332701 tgtcacgttt gactaacaac aggcttcagt cccgaatcgc aggttacgat gtttttaaag 3332761 aacttctggg cgttgctaac aaaaagaaaa aacgcatatt tctgtacggt gcgaagaaag 3332821 atgttataaa aggtgttgta tccaaaattt cttctgaata cccaaacatt aaaatcgcag 3332881 gttattcaga cggttatgtt caagatcgca ccctagtggc aaaacaaatt gcaagagcaa 3332941 atcctgacat ggtattcgta gctttagggt atcctcatca agagaaattc attcataact 3333001 acagacactt gttccctaaa gccgtatcta taggtctagg aggaagcttt gatgtattta 3333061 gcggtaatgt caaacgggcc ccttcctgga tgatacgttt aaatttagaa tggttctacc 3333121 ggttaatctt gaatccatgg cgatggaaaa gaatgcttag catcccaaaa tatgctttaa 3333181 cggttttaaa agaagaaaaa aacaaaaaaa ctttctatcc aaagcctgaa aaagatcata 3333241 caaaacagat ttaaaaacaa aactttcaaa taaatggatg ataaaaatga aaataagatc 3333301 actactggcg aattgctatt tgtatttttt atcagcaatc gccttttttc tgcaatgggt 3333361 gaaacctgaa agcaaagtga ccctcctgat ctcattcgaa gcaaacgcaa aagcgattct 3333421 tgaggaatat gaacaaggac aatactctta taaacttaac atcctgtata cccagcaggc 3333481 ctctgctatt gccgagagct tcccgaatgt agatgcatat ttattacaag aaaaaaaccc 3333541 tatccatctc attaaagctg tatacctaat gtttaacagt aaagtgatca taacagataa 3333601 ttactttcta ttaacaagtg tgttaaataa gcggaagcaa acgaaatgta tccaagtatg 3333661 gcacgcaaat ggctcactca aaaaatttgg tttggaagac attacaaaca tgcaacggac 3333721 gaaaactgat attaaaaggt tccaaaaagt atacagttcg tatgattatt taactgttgg 3333781 ctcagaagag atggcaaata tcttcaagaa atcatttgga ataaaggata accaattatt 3333841 aaaaataggt gtacctttaa cagaccctta ttaccgagaa aacaagaaaa aaatttcaga 3333901 tactctaaac atacaaagaa aaaaaataat cctctatgca ccgacgttta gagattataa 3333961 tatgcaatca attcaattgc cttttacaga agaacaatta attcatcagt taaaagaaga 3334021 atatgtttta tttgttaagc tgcatcccgc cattcagaac aatattgata ttaaatattc 3334081 cagtgattat attaaagatg tttctaacta tgccttgttt gatctactca tggctgcaga 3334141 catattaatc actgactatt cttctgttcc ctttgaattt tcgattttaa ataaacccat 3334201 tcttttttat acttacgatt taaaacttta tcaacagaag cggggattgg ttgataatta 3334261 tctttccata atacctggaa gagcctgcta tgacagtgaa tcattaataa atgaaattca 3334321 aaccccattt aattattcca aaataaaagt tttttccgat agatggaata agtattctga 3334381 tgggaattca agccaaaatt tattgaattt catcgaaaat ttaataagct aaatgatgac 3334441 acttgttcaa aacagaacaa gtgttctttt ttctattgaa taccgaacgt atgtttgctt 3334501 taatgtaatt agttgcttat ggcagcaaat aataatagag gtggtaaatt tatgagaaaa 3334561 aaagaactgt ttgatttcac caacatcacg ccaaaattat ttactgaact acgtgtagca 3334621 gacaaaaccg tacttcaatc attcaatttc gatgagaaaa accaccaaat ttatacaacc 3334681 caagtcgcaa gtggattagg aaaagacaac acccaaagct atcgcataac tcgtctatct 3334741 cttgaaggtt tacaattaga cagcatgctg ttgaaacatg gaggtcatgg tacaaatatt 3334801 ggaattgaaa accgtaatgg caccatttat atttggtctc tatacgataa accaaacgaa 3334861 acagataaaa gtgaattagt ttgtttccca tataaagcag gcgcgacttt agatgaaaat 3334921 tctaaagaac ttcagcgatt ctcgaatatg cctttcgatc atagggttac acctgctctt 3334981 gatatgaaga atagacagtt ggcaattaga caatacgata caaaaaataa taataataaa 3335041 cagtgggtga caatctttaa cctggacgat gcaatagcaa ataaaaacaa tcctctttat 3335101 actattaaca ttcctgacga acttcattat ttacaaggtt tctttttaga tgacggttat 3335161 ttatattggt atacaggaga tacaaacagc aaaagctatc cgaatctcat aactgtattt 3335221 gattccgata ataaaatagt gctgcaaaaa gaaattactg ttggcaaaga cttgtccacc 3335281 agatatgaga ataacttccg tgaaccggaa gggatctgta tgtacaccaa tcctgaaact 3335341 ggggcaaaat cattaatggt gggaattaca agtggaaaag aaggaaatcg tataagcaga 3335401 atttatgcat accattctta tgaaaacttc atgaatcatg tacctatgct tcgatcccct 3335461 ttattaaaaa ccgtggggca ccaagataca cctccagaaa gatttcaacc atttattcaa 3335521 accttcattt tagagtataa tgctcaaaac aaaaaatgga tggttccgac ttcaggttat 3335581 ttaccatctt acacatcaaa tttagtccga aatattacta tcaatgcaga tggaaacttg 3335641 caagtcacat taaatgaacg ctatattagt ttactgcatc aatcgataga aggagatttc 3335701 cgcttaaaac aaaaggatat ccgaatggga tcctggtatt ttgccggcgg agaaaaatca 3335761 aatgtgcttg aaataggttt tatgaaaggg agtacaaaaa tcagacccga tgatgcagcc 3335821 atctcaaatg cttcaagaat gagtattttt atgattgttg cggacaagat tgaggtgtga 3335881 taatcaaata ggctgtagct atttaatagc tacagcctat ttgcaacttt ctaagttttt 3335941 tatcgatatt ccggaacatc aaaataaagt gtataaccgt ccagcaatga atacaggctg 3336001 tacatgcggt ttacttgttt gtacgcccag ccgatgtctg ttgcgtattg atgtgtcgct 3336061 gtagctgacc atctcatttt gtacagtgtg tcttgattgt aagctgtgtt gtggatatac 3336121 gatgagccta tgaatttagc tccgccgata atggccgctt ctggtgtgaa ccagccctgc 3336181 tcgtacgcat atttggctcc gtagtaattc ggattgctgt cgtatgctcc aattccatac 3336241 atgttgtata cggtttttcc gttataggtt aatccattgg ctaaagcgga tgtcccgttt 3336301 cctgtttcca gaagagcgtg tgagattaaa tacagttcgt tgatgctata ttgattggcg 3336361 gcatcgataa atgcctttgc tctccctgtc aggatgcctt tacccgcaag cactttctga 3336421 tttacctcag taacgctgag acccgctgtc tgtgacagct tgagaaattg gaagtagtat 3336481 ttgctgtctc tggaaaagtt attcggatcc acgtattgaa ctacttcatc actgcttgcg 3336541 tttcgccagc ccaaattgat cttagcccag ccgtttatct gtccgatgac tttcacttta 3336601 tcgccttttt taaactggcc gatcacgttt gtcgggctga cttccggcgt tgaccggata 3336661 tttagtacat cagccgtaac agttgatgtt gctgtattaa tgtacgtgag cgatacgtaa 3336721 gccgctccgt ctgtttgcgg acttactgtc atttgttttt ggaccatatc acgaagcgag 3336781 agattgtagt ttgttttcat gatttgcggg ccgtttttga tcttcacgat agatgatgtc 3336841 catccgtata attgttttag cttcgttgat gccgcagcag ctgtatcatt gcctgtgaac 3336901 tgctcattta cgctgatttt ataaagcgta ttgcttttcg ttgtatagct cggggttaca 3336961 cttttcgatt taagataggt taacccattg ttcaatgcgg ttttgctgct aagctgtgtt 3337021 gtcacgattt tgtattgtgt atatgcagtc tggcctgttt ttgatgttgt gactgcgata 3337081 tgattttgtt tgaaaaatgt taaaacgcgg tcaatctctt cttggctgat gatagcttca 3337141 gttgtgattt gatagctgct cgcagctgtc tgaccggttt tctggcttgc tactgatata 3337201 tgattcgatt tgaaaaacgt gagtgcctga ttgactttcg tttgatcaag cagagattcg 3337261 gttgtgattt taaacgtgtc agctatttgt tttttgacgg atttcgcaga agcacttagc 3337321 tgatttttct ttaatatgtt caaacccttt gtgacttttg cttgatctga tgtttcttct 3337381 gagatgagct gatattgatt ttctgctgtt gatccagctg ctgtttttgc agcttttact 3337441 tttttctgag caaagaaggc tgctgctttg tttgcttgct gctcgcctaa aatctttgcc 3337501 gtcgtgattt gataagctgc agacgttgtc gtttttttga cgctggatga cgtgtaatgc 3337561 cattttttct ttttaaagaa agtgtctatt ttttggagct gctgttttgt tatacccttc 3337621 atattcacgg tatatgatgt gctttttcca acctgttgat aactgccgga tacgccagtg 3337681 tttttcttga tttggctgat ggcgtccttt actgtactca gccctttgaa ataagctgat 3337741 tggacattgt atgactcaac ggttgttttt tgattgatgg acttgtagct gcctgtgatg 3337801 ccagtgctct gtttcagctg ctgcaataga gttttggcat tggcttcacc tgaaatggcg 3337861 gcagttgtga acgtataata ggcttgccct ttcactgttt cctttaatga tgcctgcagc 3337921 ccagattcct tttggaaggc gtttttgatc tgcgctgctc tgctgtctcc cacgattgtg 3337981 ccagactgaa tggttgtgac agacaccgtg tgtgtgatgg gctgatacga gcttttaatc 3338041 cccgtttgct tggccaggct ctggataagc gccttgactt ttgtctcatc agcaatgtct 3338101 gatgtcatga cgttcatata gggctgagct gctccgtaag cttttacagc gccagccact 3338161 cccgtctcct gtttcagctt tgctaggata gtgttggcct gtttttctcc ggagatggca 3338221 cctgacgaga tggtgacata tggctgtttg cttccaacag gacttgacgt tcctgtaatt 3338281 gatgtctgtt tggcgagtcc gctcagtatt gctttcgctt ctgattcgct atgaatgcct 3338341 gaggcggaaa tttggtaggt cgttgttgtg cctgaagcct gataggatgc atcccagcca 3338401 gtatcttttt ccagtttggc gacagcttgt gaggcttggc tttctgtact gaacgtattc 3338461 gacggctcta ctttatatag tgagtagtcg gtatacgcgg ctgcctgggc agaaccagac 3338521 atggcaaaaa aggcaaggga cgcggcggat agaagcatag gtgcgattag tctctttttc 3338581 attccttctc ctctttctta ttctatgagt atataaaact agtttattta tcggcacgcg 3338641 catgcttcat ttataggtga atcacttcca ttttctaata aaaaaactta acctcgaagt 3338701 gagattaagt ttaaatatga gacacgataa gggtacaagt tccttttatc gtaaaatcgg 3338761 gcatttgagc cggcaaaata aagtgatcac cttttttgag cggacatgtt ttgtcctcat 3338821 acttgagcaa accgcttcct tctatcacgc tgcaaatcag aaaggattca tcctgagcca 3338881 tttcagcttc gccattgatg tcccatttat aaaccgaaaa atattcccct tggacaaatg 3338941 ttttaatggt tattcctttt cttgattctg tcgattcatc tatatacccg tccacatggg 3339001 gaaccgtggc ggcattgacc gctttggcaa aatgaagctc tctcggactt ccgttgctat 3339061 caagacggtc ataatcgtac acccggtatg tggcatctga attttgctga gtctctaaaa 3339121 caagggcccc cttgcacaat gcgtgcagcg ttccgctcgg cacataatag aaatcacccg 3339181 gtttaatttt gattcttcgc agcaggccct cccagtcacc gctgttgatc attgtgacaa 3339241 gttcggtttt tgagcgggcc gtatgcccgt aaatgatttc tgcgttttcc ttacagtcga 3339301 taatgtacca gcattccgtc ttgccgagtt ctccctcttc gttttctccg gcatagtaat 3339361 catcagggtg aactttaatt gacgtatctt ccttcacatc cagcagcttt gtcagaagcg 3339421 gaaaccgatc cccctctacg ccgccgaata cttcacggtg ctcttcccaa agctcgatca 3339481 atgtctttcc tttatacggg ccatttgcaa cagtgctcgg tccttttgga tgagcggaaa 3339541 tggcccagca ttcccccgtt gattctgaag gaatactgta tccaaatcta tctcgtaaag 3339601 cggttccgcc ccagattttt tctttaaaca caggcgttag aaaaatcggt gattgcgtca 3339661 tgatccgtac ccctcccctg taaataactg atcatcattt tcccggtgcg cccctcttac 3339721 aaacgcccgt ataagctgcc tttttcctat gacaacatat gtacaaagca tcatcttttc 3339781 attacccctt caaagaaaac gcttcctatc tattatatca cgtcgaaaag aagctttgtt 3339841 tcagcctttt cctcgataag aataattctc cttttttgat acaaattaat aaaaaccgtc 3339901 aatatgttta agaaggagag aaactatgca aatcgactct gatctccaga acaatttaga 3339961 cacactgaaa aaaacattgg gacaaaacga cgatatgatg ttttatacat ttgctttcgg 3340021 agatagcaga caaaaggcgt gtttactgta tattgacggt ctgacagaga ataaaatgct 3340081 ggcgcaatac gtcatttctc ctttacaaaa agaggcgttg gcccataagg aatgctcgat 3340141 tgaagactta tccgcctttt ttttcggctt tcaccacagc gttgtttcta caatgaaaga 3340201 aatagagcag ctcgtttttt cagggcaagc cattttgctc gctgatggct atcgcggagg 3340261 attagctttc gacacaaagt cagtcgcaac acgcagtctt gatgaaccct cctccgaagt 3340321 cgtggaacgc ggccctaaaa taggatttat tgaaaagctg cggacaaaca cggcgctttt 3340381 gcgtgaacgg acgagtgatc ctaatctcgt catcaaagaa atgacactcg gaaaaaggac 3340441 caaaaagaaa atcgctgtcg cttatattca ggatatcgcc ccagattatg tcgtcaaaga 3340501 agtgtttaaa aggctgaaat cagtcaatat agataatttg ccggaatcgg ggacgcttga 3340561 acagctgatt gaagacgaac cattttcaat tttccccaca atattaagca cagaacgacc 3340621 ggaccgggtc gaaagttctc tattagaagg gcgagtgtcc atattagtgg atggtacgcc 3340681 gtttgctttg attgtaccgg ctacggttga cgaatttatt cattcgcccg atgattacag 3340741 ccagcgctgg atcccaatgt cacttgtacg ccttcttcgt tattccagca tcctgatcac 3340801 catttatttg cccggtctgt atatttctct cgtttctttt cacaccgggc tattgccgac 3340861 tagaatggcc atttccattg caggcagcag gcttaacgta ccattcccgc cttttgtaga 3340921 ggcctttatc atgatcttta cgatcgaatt gattcgagaa gccggattaa ggctgcctaa 3340981 gccgattgga cagacaattg gccttatcgg cggcgttgtc atcggacagg cagctgttca 3341041 ggcgcaaatt gtcagtgcgc ttatggtcat tgtcgtttct gtcacagcac tggcatcctt 3341101 taccgttcct tcatacgcct ataactttcc gctgcggatc attcggatcg gggttatgat 3341161 aagtgcaaca gcgcttggca tgtacggcgt tataatggtt tatctgtttg tgatcggcca 3341221 tctcatgcgc ctgaaaagct ttggccagga ttacattatc ccgatcatgg cgcagcctgg 3341281 acaggatttg aaagacacag tcatccgtat tcccacgatg tttttaaaaa gaagaccgac 3341341 acgaaacgat cccgaagata acatcagaca aaggtgatgg ctatgaggaa atcagagcat 3341401 aaactgacat ttatgcagac gctcattatg atcagcagca cattgattgg tgccggggtg 3341461 ctgacccttc cccgctcagc cgccgaaacc ggcagtccga gcggatggct aatgatactg 3341521 ctccagggcg ttatttttat tatcatcgtt ctgctttttt tgccttttct tcaaaaaaac 3341581 agcggaaaaa ctctttttaa gctcaacagc attgtagctg gaaaattcat cggctttcta 3341641 ttgaatttat atatctgtct atatttcatt gggattgttt gctttcaagc tcggattttg 3341701 ggagaggttg tcggattctt tttgttgaaa aatacgccaa tggcagttgt ggtgtttata 3341761 tttcttgcag ttgccatcta tcatgtaggc ggaggcgttt attcaattgc aaaagtatac 3341821 gcttatattt ttcctataac ccttattatt tttatgatgc ttctgatgtt cagctttcgc 3341881 ttgttccagc ttgattttat ccggccggta tttgaaggag gctatcaaag ctttttctct 3341941 ttattcccaa aaacattatt atatttctcc ggatttgaaa tcatttttta cctggtcccc 3342001 tttatgagag atccaaagca agtgaaaaag gctgttgctc tgggcatcgc gacttccaca 3342061 ttgttctaca gcattacttt gctcattgtg attggctgta tgactgtggc tgaggcaaaa 3342121 acggtgacat ggccgaccat ttcccttatt cacgcattag aggttccggg tatttttatt 3342181 gaacgatttg atttgttctt acagctgacc tggacagccc agcaatttgc ctgtatgctc 3342241 ggatccttta aaggcgccca tatcgggtta acggaaatct ttcatctaaa aaataaaaac 3342301 aatgcatggc tgctgactgc aatgctggct gcgacgtttt tcataacgat gtatcccaag 3342361 gacttgaatg acgtgtttta ttacgggacg cttcttggat atgctttctt aattgtgatt 3342421 acaattccat tcttcgtctg gtttttaagc tggatacaga aaaaaatagg gagggggcag 3342481 ctgcaatgaa aacagcatca aaattctccg tcatgttttt tatgctgctg gccctctgcg 3342541 gctgctggga tgtcaaagat atcgagcaac tatccttcgc cagagggctg gcgatcgatg 3342601 agacaaatga tcaccagtac aaactgacgt atcaaaatct tcttccccaa agcgaagaca 3342661 gccaagcatc cggaaaaccc gaatttgtta atgtaacgtc ccacgggaaa acgattctgg 3342721 aagcagtcag tgatgtatcc atcaaggacc ctcctgttta tagcgatcat ttaaaagtga 3342781 tccttctggg agaaaaactg atgaggaatc aaaatgtaga ccaagtcctc aaccacttta 3342841 tccgggatga tgagctgcgg cgaagcagct atttgatggc agccagaggg aatgcagctg 3342901 atgttttcac aaaaggaaac cccaatcagc agcagccgat gccctccgaa aaactgattg 3342961 atttgacaac tcacagcgga tataacggta agattatgat accgctgcgc atcggaagag 3343021 cttctgtcta ctctcagaac gggtacagtt atcttattca agccgtgaaa aacgaaaagg 3343081 gaaaagccaa gtatgacgga gcaggcatta tcaaaagggg cagcaataaa ctcgttgggt 3343141 ttctttcagc tgatgaaacc caaacactgt catgggtcat ggggacgatc caaggcggtg 3343201 tcatgccgac gacagataaa ggacatccga ttacgtttga aattaaaaag tcgaaaacga 3343261 aaattaagcc cgtcattgaa aacggaaagc ctgtctttca tatttctgtt aaaacgaagg 3343321 gcatcctgac agaagaccaa aacccgaatg aaaactcctt tagcaaaagt tatttgcaca 3343381 ggctggaaaa catttttgaa aaaaagcttg aacgagatgt aaagcaggtg atggataaac 3343441 tgcagcacga gtataaaacc gatccggtct ttttatcaga ccacataagg attcaacacc 3343501 ctgactactg gaataaagta aaagggcatt gggatgaaat attttctgag actgatttta 3343561 agtacgatat ttcttttaaa atcattaact ttggcacggt gggaaagtaa gcaatcaaaa 3343621 gggtgcgcat gatcgcgcac ccttttttat gttccgacag tctgctgttt tccggccgct 3343681 cctccctgtc cgtttttgtc ccgtaaatcc tgctcaattt cttcaaggct tcttcccttt 3343741 gtctctgtca ctttaaatcg gacaaataag aacgccatga taccgatcgc ggcataaatc 3343801 aggaataaat aactgattcc gatcgcttcc attaatattg gataggttaa tgaaacaatc 3343861 agtgtcccaa cgtgcaacat taaggtcgaa acaccggtcc cgattcctct gacgtgaagc 3343921 gggaacaatt caggaagcat cacccacaca accggtcccc agctgaccgc aaagacaacg 3343981 ataaacacgc ctaaacaaat gacggtcgtc catgaggcag ccggagtgtt atcgaaaaag 3344041 agatttacta aagcgagaac gatcaagctg atcaccatgc ccgcattccc gaatagcagt 3344101 aacggctttc ttccaatctt gtcgatgatt ttaatcgcta ctaatgtcat gagaacattg 3344161 actgtgccga ttccgaccgt gcctaaaatc gaagcggagt ttccgaatcc gacgtttgta 3344221 aaggtctttg gcgcatagta gatgatcgta ttcgttccga taaattgctg caaaaaagcg 3344281 agtcccaaac ctgcaataag cgctgggcgc acccatggat cgaacagctc cttcagaccg 3344341 ccttcatcct gcttttccgc ttcttttata tcatgtattt cctgatcaat atcttttgtg 3344401 ccacgcaatt tttcaagaat tttcttcgct ttgctttctt cgccattcgt gaacagccag 3344461 cgcgggctct ccggcataaa caaaatgcca ataagcaaga gcaatgacgg cacagcagcc 3344521 aatccaagca tccagcgcca cgcttcggca tcggcaaata tgtaattgac aatgtaagaa 3344581 agaaggatgc cgaccgtgat catcagctga ttcagtgatg acagcgcccc gcgtttatgt 3344641 tttggcgcca gttcagataa ataaaggggt acgattgtcg tcgatgttcc gactgcaagt 3344701 cccaaaatga tgcgaaacag caccatgact cctgtatttg gggccagtgc cacaccaaga 3344761 ccgcctatac aaaacagcag cgcggctgcc ataattgctt tttttcttcc gaaacggtca 3344821 gtcagcttgc cggccgctcc tgagcccaat atcgccccaa ccagcaagga gctgacaaca 3344881 agaccttctg taaacgcgtt taagcctaac tcctttttca taaataaaat agctccggaa 3344941 atcactccgg tatcatagcc atataacgcg cctccaagag ctccgaaaaa ataaagccat 3345001 atatttgact gctttttcat aaagatgact ccctttctcc atcagctgca atgacattgt 3345061 ctgtgggatt tttttagaaa tcttttagcc tctttttccg gccattaaac ctttttattt 3345121 ttctgatcat aagttttcca atcatttact tgtatttttt tcaatgtcgc cgaaacattt 3345181 tacctgctgc ggcgtccaat ataaggtgat tcagtacatt atcgttatca attttcaaaa 3345241 acaagaactt ataaatatag gaatatttat cgaaaaatgt ctttcgagta gttgccccat 3345301 ggcaaataga atggtacgct tcaaatatta aagaaacgtg aggtattgat atatggaaga 3345361 acgatcacag cgcagaaaga aaaaaagaaa actaaaaaaa tgggtgaaag ttgttgccgg 3345421 attaatggct tttttagtca ttgcggcagg ctctgtcggc gcctatgctt ttgtaaagct 3345481 gaacaatgct tctaaggaag ctcatgtcag ccttgcacgc ggagaacaat ctgtaaaacg 3345541 gatcaaagaa tttgatcctg gaaaagattc tttttctgta ttgctcttag gaattgatgc 3345601 cagggagaaa aacggcgaga ccgtcgatca ggcaagaagt gacgcgaatg tgctggttac 3345661 atttaatcgg aaagaaaaaa cagctaaaat gctgagcatt ccgcgtgacg cctatgtaaa 3345721 catcccaggc cacgggtatg ataaattcac acatgctcac gcttacggcg gcgttgactt 3345781 aactgtgaaa acagttgaag aaatgctgga tattccagtc gattatgtcg tagaaagcaa 3345841 tttcacggct tttgaagacg tcgtaaacga gttaaatggc gtcaaagtaa ctgtaaaaag 3345901 cgataaagtc attcagcaaa tcaaaaaaga tacaaaaggt aaagtcgttc ttcaaaaagg 3345961 aacacatacg cttgatgggg aagaagcgct cgcttacgta agaacacgta aagcggacag 3346021 tgacctttta cgcgggcaaa gacaaatgga agtgctgagc gccattatag ataaatcaaa 3346081 atcattgagc tcaattccgg cttatgatga tattgtggat acgatggggc aaaatttaaa 3346141 aatgaactta tctcttaaag atgccatcgg cctgttcccg ttcatcactt cattgaaatc 3346201 agttgagtct attcagctga cgggttatga ttatgaacct gccggagtct attatttcaa 3346261 attgaatcag caaaagctgc aggaagttaa aaaagagctg caaaacgatt taggtgtata 3346321 atgaacggga tggcgattac gccatcccgt tttacatatt tccttgttga aaattatcaa 3346381 agtaacgttt agccttaatt tatatggatt atgtttcaca ggcaagctga acatactaca 3346441 cgaagcagct tcatttttaa ggaggttccc ctacatatga aatgtattgc gattgatcta 3346501 gacggaacat tactgaataa agaaagcgtc atttctgcgg aaaacagaga ggcgatcaag 3346561 cgggccgttg atgccggcat cctcgtcacc atttgcacgg gaagagcgac atttgatgta 3346621 aaagcgctgc tggatgactt ggacatccct atcattgcag ctaatggcgg tacgatccac 3346681 gacacgggtt accgtttgat cagccggaca ttaatggatc aggaagccgg taaagcgatt 3346741 gctgattact tactttcaaa aaacatttac tttgaggtat atacagatga ccatctgctt 3346801 tctccttttg acggcgaagc taagctgcac gcggagcttg acattctaaa gagcgcaaac 3346861 ccaaacgagc agacggatga cttgtggcaa ggagccatga ctcaattcaa acagtttggc 3346921 attaaaccaa tccctcatat cgaatcggtt tttgacggcg gtgaaaacat ttataagctt 3346981 ctttgcttct cctttgatat ggacaagctg aaacaagcga aggaagaact gaagcatcat 3347041 aaaaaactgg cgcaaacctc ttcaggaaaa catattatcg aaatcctgcc ggcctcgtca 3347101 ggaaaaggac gcgcgttaac aaagctggct gacatatacg gaattgaaac acaggatatc 3347161 tatgcgatcg gcgatagtcc aaacgatttg tccatgtttg aagtcgccgg acaccgtatc 3347221 gccatggaaa atgcgattga tgaattaaaa gaaaaaagca cctttgtcac aaaaagcaat 3347281 gacgaaaatg gtgtggccta ctttatagac cagcttcttt cggggcaata tgcataaaga 3347341 aaagactcca gagattggag tctttttctt ttattgcacc cgtatacttc ctgcgtattt 3347401 atccttccaa tatgtgctcg tgttcatatt ggtaatggtc acgccgtttg ataatgtgac 3347461 atgaacaact tgtccgtttc cgatatagat ggagggattt aagcttgttg attgaaagaa 3347521 cacaatgtct cccggcttca ggtccgcctt ctcaatctta gttccggcat tgtactggct 3347581 tgttgcgtat cgaggcaggg aaataccggc tgctttctgg tatacatatt ggacaaatcc 3347641 agctgtatca aatcccgtct caggtgttac tccgccctgt ttgtaaggca cttctccgac 3347701 ataaagcgtc gcttcggaaa caatcggatt ttctttcggg attgtcaggt tgtcaaatcg 3347761 gcgaataccc gtcatcttcg atttccagta atcctctgac aaataggaaa tggttacttt 3347821 ttctgaccgg cttgcctgaa tgaacctgcc tgcgcccgca taaatgcctg catgtgaaat 3347881 tcccgtttta tacgtattgc tgaaatagac gacatcacca ggctttatgt tctgaggggc 3347941 taccttctcg cccactgccc actgctgttc ggctgatcgc ggtagataaa tgccgagtgc 3348001 ctgttgaaac acatattgca caagccccga gcaatcaaag ccctctgacg gcgtgcttcc 3348061 gccaaacaca tatgggacac cgatatattt ttcggcctcc tgaacgacag gaacatcagc 3348121 cgttgccgga tcggcagcga ttcgtctcgc cccgatataa gttccgctcc aatagctgct 3348181 ttttttgtaa ttggtgatga taaccccttt tgactgtgta ctgtgaacca tttggccgtc 3348241 tccgatataa agggcgtcat gtgtcggaac agtgccggtg cttccctctt tcttgaaaaa 3348301 caaaatatca cccggcttca ggttttccgg ttttacagct gttccgattt tatactggtc 3348361 gtttacagat ctcggcagat gaatatcagc cttactgaac acatattgta tcaatcctga 3348421 tggatcgaaa ccctctttcg gcgtttcccc gccatattta tactgatatc caagcaggtt 3348481 ttttgcttcg ctgacaatca attctgatga tgtatcagct tccgcaatct ccgcttttgt 3348541 cataattgga accaaaaaac aaatgataac cgccacaagc aaaaacttct tccagtttgc 3348601 cagtgtgttc acttttatta tctcctcctc tttttgcagt tttaacatcg gtattttttt 3348661 gaatatgtta agagactttt taatattttt acagaatgaa tatgctgggc aaataaaaag 3348721 agagtgtctc atcagacact ctcttttttg aattatttat tggcgtttac cggttcttcc 3348781 tgctgctgga ttttattcat ttccatatca atcttctgtt tttcctgatc tgtcagctga 3348841 tcattgaatt taaaagctga cataaacatg aacacgatgg ctacggcaac aaacggccag 3348901 atggctttga caaatttcat ctttatcact ccgattattt agattttagt ttgtcactat 3348961 gatcaatatc aaacgtcagt tttccgtctt ctactttcca agcgaaatta gagtctttcg 3349021 tcagttcgcg aataatggtt ttctgtttaa ggctgtcttt tttcacaggc gcaggtgtcg 3349081 cttcatggat atcgatcggt gtcacttcaa agcgtcctgt tccatttttc ttcaggtgat 3349141 actgaaccag tgcactgtct cttgttctcg tccagccttg gtcaaagaca aagttgccga 3349201 ggctgtagaa aatgacggtt ccgttatata cttcaatcgg ttctaagacg tgcgggtgat 3349261 ggccgacgat gatgtcagct cccgcatcag acatggctct tgcaagctgg cgctggcggt 3349321 catttggatc attgtcatac tcttgtcccc agtgtgactg cacaacaaca atgtccgcat 3349381 gttttttcgc ttctgaaatc atagggatga agatttcagg atctgcgggc agcacgcccg 3349441 gcgtattctt tttagccgcg aaacctttcc cggacacatc ggtaaagcca agcgtcgcaa 3349501 tcgttacccc gttgactttc tggtacgaaa ttttcttttt cgcatcactt aagctgtatc 3349561 ccgctccaac gatatcaaga ttttgcttcg caaattctcc aagcgtatct ttcatgccct 3349621 gaacgccgta atccattgcg tggttgttgg cgctgttgag aaccgtgaaa ttcatatcct 3349681 tcaagacttt cactgattcc ttattcgtct gcagatgaat ctctttatct gcttgtttat 3349741 aattcttttg ataggttacc gggttttcaa agtttcctgc tacataatcc gaggctctaa 3349801 agatcggttc aacatattga aaaatactgt ctgccccttt ttgctccgtt actttttcaa 3349861 catagcgtcc catcataata tcgcctacaa atgaggctga gagtacgtcg tcagaatacg 3349921 ttttgacctt cggcgtttcc gcttttcccg cccacatgaa agcgaacata aggacaaaaa 3349981 cgatcggaat ggcaataaat acgtgcttat tggttttctt tttttgctgt tttgtcagct 3350041 ttagcagctt ttcatgaaag ctcagttctt ttttcatcgt ttgacacacc ttacattaaa 3350101 ttaagtagta aacaaacatg atagcaaagg tcgctccgct caatagcagc gtgcttccga 3350161 acgtaatggt taaaccttgt ttctgaatgg tattggcaat taaacctggc acgatgatgc 3350221 cgattcctcg aaattctgcg atttcaaatg gtacaatcgg gtatagaaaa tcaaacgcga 3350281 tttttaggac gatccctgtt atcagcatgg cagcgaattt tctgcgtccg tacaaaatca 3350341 taaatttgga taaaccgtat ttcacaatga catacgtgag caagctcact agcaaaacaa 3350401 gtaaaataaa gaccggctga ttaaacacaa gtcctaaata tcccggtaca acaagtcctg 3350461 ccggcacgat ccctgttttt tccgcaaaaa ttaaactgag tagtacacct aaaattagtg 3350521 cgatgtataa atctgatccg aacatgtctg catttccccc tagcttacga gctgctttac 3350581 cttgtattcg tggatttttt caattaaagg ctctgcggca ccatgaatat tgccgacgcc 3350641 atatatgaca cggttgtgca ttcttttctt taacaattcc ataatttcat ctgttgactt 3350701 atactctaga tcatgcagtt tgtctgcagg aattttgcct tcttcgtagg cttttacgat 3350761 cggttctgtt gtttcaccga ttaagatcag ttcacttgct tcaatataag gcaatacgtc 3350821 atttgcgaat tgctgtgtcc gatcgacacg gtctgcgcgg cagttcatga tgatgatcgg 3350881 atcatcggtc gggtaaccga tttcttttac acgtttccat atattcaaag tagaagaagc 3350941 gtcgtttgcg gcaaacccat taacaaagtg cccaggctcg ctcggactga tcagcggaag 3351001 aattctcatt gctcccggat ctggcggcgc attcagcatt cccttaaatg ctgtttcttc 3351061 gtcaatgccg agtgcttgag ccacacccag cgccagagaa gcgttatcag ggaataccat 3351121 gtattcaaat ttacgtaaat actcatctgt aatttttgag ttatcagcaa tgatgacttt 3351181 tgtgtttcgt tcttttgctt tttgtttaaa gaactcggta tattcactat ctgtaatgac 3351241 aagatggcca ttataaggaa ttgtagcagt aaacgcttct gcaatttcat caagcgtcgg 3351301 ccccatgaca tccatatggt cttccaaaac attcacaatg acgccgatat tggcctgcag 3351361 aagttcttcc tgaaagatga tttgataatc tgggttaaca gccatgcatt cactgacaat 3351421 cgcgttagcc cctctttcta ctgtttctct catgacttct ttttgctctc cgatattcgg 3351481 cccctgaggt ttccgtttaa tcggcttttc ctccggtgtg tcccagtaaa tcattcttgc 3351541 atctgttcct gttgtttttc caacagtctt gtaaccggct tctattaata ttccggttgt 3351601 cagccttgtc acagtcgatt ttccgcggat gccgttaata ttcacccgaa cagggagggc 3351661 atcaatgttt ttctgatgtc gtcgtttttc taatattccg atgaccagta tgacagcaca 3351721 ggctataatg agtaaccaca ttgcttttcg acatctcctt ctatattgtt gtaaattcat 3351781 tcatcagtat atagaatcac tatgaattct caatcggcat tatgtaacat aatcttccct 3351841 aatcgactaa gccaaacttc tcttttgaaa gagattttat acctacaaac tgttttctat 3351901 ttttggaaaa cagcaggact tataccttat cactttttaa aaaaatcaaa gagaatgcgc 3351961 tttcattttt ctcctgatat ccttctggac gtatagtcac accctgctgt ttgtatttaa 3352021 tatgcatttc aaatcaatct ttttttcagc ctttgttatc aagcatttcc tgctatcatg 3352081 cgtgtttccg gttcttatga acacaaaata attttatcct gtttcttaag gacaaggtca 3352141 taatgtcatc ctttctgcat ggaataagca atatgaggcc cattccaaaa tgactaagga 3352201 ggttcgagat gaaaacgcta aacatacgag tccgaattct ctaacataat taaacatttt 3352261 ctgggatgat agtcttttct gtttctcccc atttacaggt ctaaacgcat gactttgaaa 3352321 caattttaat aaaacttaat atttgttcaa gaaatcttca tccatatttg tgaagacttt 3352381 gtcaaaaaaa gagtgaaaac cttaaatttt tcaattatat atacaattta caattagatt 3352441 tcttttgata tttttattgc taacttcgga ttgttcatga taatctatct atgtaaacgg 3352501 ttacataaac aaggaggagc tgttttggct acaattaaag atgtcgccgg agcggcgggc 3352561 gtttcagttg cgacggtttc ccgcaacctg aatgataacg gctatgtaca cgaagaaacg 3352621 cgaacgcgtg tcatagcggc gatggcgaag ctgaactatt acccgaatga agtcgccaga 3352681 tctctatata aaagagaatc ccgactgatc ggacttttgc tcccggatat cacaaaccct 3352741 ttcttccccc agcttgcccg cggtgcggag gatgaattga accgggaagg ctatcgcctt 3352801 attttcggca acagtgacga ggaattgaaa aaagaacttg aataccttca aacctttaag 3352861 caaaatcatg tcgcaggcat tattgccgca acgaattacc cggatctcga ggaatacagc 3352921 ggcatgaatt atccagttgt ttttctggac agaacgcttg aaggggctcc ttctgtgtcc 3352981 agtgacggct atacaggagt aaagttagcc gcccaggcta tcattcacgg aaaaagccag 3353041 cgcattacgc tcttgagagg acccgctcac ctgccgaccg ctcaagaccg atttaacggc 3353101 gctttggaaa tcttaaagca ggctgaagtt gattttcagg tcattgagac agcttcattt 3353161 tcaattaaag atgcacaatc gatggcgaag gagctgtttg cctcttatcc agcgacagat 3353221 ggtgtgatcg cgagtaatga tattcaagcc gctgccgttt tacatgaagc attgcggcgc 3353281 ggaaaaaacg tgccggagga cattcaaatt atcggctatg atgacattcc gcaaagcgga 3353341 cttctgttcc cgccactttc tacaattaaa cagcccgcat atgatatggg gaaagaagct 3353401 gccaaactgc ttttgggtat cattaaaaaa cagccgctgg cagaaacggc aattcaaatg 3353461 cctgtcacct atataggaag aaagacgaca agaaaggaag attaagatgc gtaatatttg 3353521 tgtgattggt agctgttcta tggatttagt ggtcacctcg gacaaacgcc caaaagccgg 3353581 tgaaacggtt cttggcacgt catttcagac tgtgccgggc ggcaaaggag caaatcaggc 3353641 cgttgccgca gccagacttg gggcgcaagt gtttatggtc ggcaaagttg gagacgatca 3353701 ttatggaaca gctattttga ataatctcaa agctaacggc gttcgcactg attatatgga 3353761 accggttaca catacggaaa gcggaaccgc tcatattgtg cttgctgaag gcgacaacag 3353821 cattgtcgtt gtcaaaggcg cgaacgatga catcacccca gcgtatgcgt taaacgcgct 3353881 cgaacagatt gaaaaggtcg atatggtgct gattcagcag gaaatcccag aagaaacggt 3353941 tgatgaggtg tgcaaatact gccattctca cgatatcccg atcatactaa acccagcacc 3354001 ggcccgcccg ctcaagcagg aaacaattga tcacgctacc tatctgacgc cgaatgaaca 3354061 cgaggcttcg attttattcc ctgagcttac catttccgaa gctctggcgc tttatccggc 3354121 aaagctcttt attacggaag gaaaacaagg cgtccgctat tcggctggca gcaaagaggt 3354181 gctcatcccg tccttccctg tagaacccgt tgatacaacc ggagccggtg atacgtttaa 3354241 cgcagcattt gccgtggccc tggctgaggg aaaagacatt gaagccgcat tgcggtttgc 3354301 caatcgtgcc gcttcccttt ctgtctgctc cttcggtgcc caaggcggaa tgccgacaag 3354361 aaatgaagta gaggagctgc tgtcatgaaa aaacacggta tactgaacag ccatcttgcc 3354421 aagattttag ccgaccttgg ccacactgat aaaattgtca tcgcggatgc cggactgccg 3354481 gttcctgacg gcgttttgaa aattgatctt tcactgaagc cgggccttcc ggctttccaa 3354541 gatacagcgg cagtactggc tgaggaaatg gcggtcgaaa aagtcattgc tgcagctgaa 3354601 ataaaagcat ccaatcagga gaatgcgaaa tttctagaaa atcttttctc tgaacaagag 3354661 attgaatacc tttctcacga ggagtttaag ctgctgacaa aagatgcaaa ggcagtcata 3354721 agaacaggag aattcacacc atatgccaac tgcatcctgc aggcaggtgt acttttctag 3354781 aaaggaagat gaaacatgca gattgaaatg aaagacattc ataaaacatt cggaaaaaat 3354841 caggtgctgt caggcgtttc ctttcagctc atgcctggcg aggttcacgc attaatggga 3354901 gaaaacggcg ccggcaagtc cacgcttatg aacattttga caggcctgca caaagcagat 3354961 aaaggtcaaa tcagcataaa cggaaacgaa acgtattttt ccaatccgaa agaagcggaa 3355021 cagcatggaa tagcctttat ccatcaggaa ttgaatatct ggccggaaat gaccgttctt 3355081 gagaatctat ttatcggtaa agagatatcc tccaagctgg gcgttttaca aacaagaaaa 3355141 atgaaagcgc tagcaaaaga gcaatttgac aaactttccg tctctctttc tcttgatcaa 3355201 gaagccggcg aatgttccgt cggacagcag caaatgatcg aaattgcaaa agcgcttatg 3355261 acaaatgccg aggtaatcat tatggatgaa ccgaccgcag cgttgactga acgtgaaatc 3355321 agcaagctct ttgaggtcat tacagcgtta aaaaagaacg gcgtctccat tgtctatatt 3355381 tcgcatcgca tggaagaaat ttttgcgatt tgcgacagaa ttaccatcat gcgtgacgga 3355441 aaaacggtag atacaacaaa catctcagaa actgattttg atgaagtcgt caaaaaaatg 3355501 gtcggacggg agctgactga acgatatcca aaacgcactc cttctctcgg tgacaaagta 3355561 ttcgaggtga aaaatgcttc cgtaaaaggg agttttgagg acgtcagctt ttatgtgcgt 3355621 tccggtgaga tcgtcggtgt ttcaggatta atgggagccg gccggacaga aatgatgaga 3355681 gcgctgttcg gcgttgacag gctggacacg ggtgagatat ggatcgctgg gaaaaaaacg 3355741 gctattaaga acccgcagga agccgtgaaa aaaggtctcg gctttattac agagaatcgc 3355801 aaggatgaag ggctcctgct cgacacctcg atccgcgaaa atattgccct gcccaatctg 3355861 tccagcttct caccaaaggg tctcattgat cataagcggg aggctgaatt tgtcgatctg 3355921 ttaatcaagc gcctcactat caaaacagca tcaccggaaa cgcacgcacg ccatttatca 3355981 ggaggaaacc agcaaaaagt ggtgatagcc aagtggatcg gcatcggacc gaaagtgctt 3356041 atcttggatg agccaaccag aggtgtggat gttggcgcca aacgagagat ttatacgctg 3356101 atgaatgagc tgaccgaacg cggtgtcgct atcatcatgg tgtcatcaga gcttcctgaa 3356161 attctgggaa tgagcgatcg gattatcgtt gtccatgaag gcagaatcag cggcgaaatc 3356221 catgcgcgag aagcaacaca agaacgaatt atgacacttg ccacgggagg gcggtaatat 3356281 gaaaacggaa caactgcaaa cagaacaaaa acggattcac ttcgacggag tcatgcaaaa 3356341 actcggcccg tttcttggtt tatttattct cgttatcatt gtatctattt taaatcccag 3356401 ctttcttgaa ccgctgaata ttttaaacct gcttcgccag gtcgccatta acggattaat 3356461 cgcgttcggg atgacctttg ttattttgac aggcggcatt gatctttctg ttggcgctat 3356521 tcttgccctg tccagtgctt tagttgcggg gatgattgtg tccggtgtcg atccggttct 3356581 cgcgatcatc cttggctgta tcattggtgc cgtactaggc atgatcaacg gattattgat 3356641 tactaaagga aaaatggcgc cctttatcgc cacgcttgcg accatgactg tgtttcgcgg 3356701 actgacgcta gtgtatacag atggaaatcc gattaccgga cttggcacaa actacggttt 3356761 tcagatgttc ggacgcggtt actttttagg cattcctgta ccggcaatta cgatggttct 3356821 tgcctttgtc atcctttggg tgcttcttca taaaacacca ttcggacgcc gaacgtacgc 3356881 tatcggcggc aacgaaaaag ccgcgctcat ttcaggcatc aaagtgacgc gcgtgaaagt 3356941 gatgatctat tctttagccg ggcttttatc cgctcttgca ggtgccatat tgacttcccg 3357001 cctgcattcg gcccagccga ctgcgggaga atcgtacgaa cttgatgcta tcgcggcagt 3357061 cgtcttagga gggacaagtc tttccggcgg ccgaggacgc attgtcggca cgttaatcgg 3357121 ggtgctgatc atcggcacac ttaataacgg acttaatctg cttggcgtct catcatttta 3357181 tcagctggtt gtcaaaggga ttgttatctt aattgcggta ttgttagacc gcaagaagtc 3357241 agcttaggag ggttttacat gaaaaaggct gtatccgtca ttttaacgtt atcattattt 3357301 ttgttaaccg cctgttcgct tgagcctccc caatgggcaa agccatcaaa ctcggggaac 3357361 aaaaaggaat tcaccattgg cttgtccgtc tcaacgctta ataatccttt ttttgtctca 3357421 ttaaaaaagg gtatcgaaaa agaagctaaa aaacggggaa tgaaagtcat cattgttgat 3357481 gcacaaaatg attcatcgaa acagacgagt gacgtggaag atttaattca gcaaggtgtt 3357541 gatgcattat taatcaaccc gactgattct tcggcgatct caacggcagt agaatctgca 3357601 aacgcagtcg gtgtgcccgt cgtaacaatc gatcgatctg cggaacaagg aaaagttgaa 3357661 accctcgttg cttccgataa tgtaaaaggc ggtgaaatgg ccgcggcgtt tattgccgac 3357721 aaacttggaa aaggagcaaa ggtggcagag cttgaaggcg tccccggcgc atctgccaca 3357781 cgggaacgcg gctcaggatt ccataacatc gcagaccaaa agctccaagt tgtcacaaaa 3357841 caatcagctg actttgaccg cacgaaaggc ctgactgtca tggaaaacct gctgcaggga 3357901 catcctgata tccaagctgt ttttgctcac aacgatgaaa tggcgctcgg tgctctcgag 3357961 gcaattaaca gctcggggaa agacatattg gtgatcggtt ttgacggcaa taaagatgcg 3358021 ctcgcttcca ttaaagacag aaagctgtca gccaccgtcg ctcagcagcc tgaattaatc 3358081 ggtaaattgg ctacagaagc agcagatgat attttgcacg ggaaaaaagt gcaaaaaaca 3358141 atatccgcgc ctctcaaact agaaacacaa aaataattgt ctgatgttta ggaacctgcg 3358201 ataacgtgaa tagagatata gaatgaatta tttctcttac gtgaggagag gaacggcatg 3358261 aacaaaccaa caaaactatt ttcaacatta gcacttgcgg ctggaatgac tgcggcggct 3358321 gctggcggcg ctggcacgat ccatgctcaa cagccagaaa caacggtaag cattgatgat 3358381 ttatacagtt atccgattga ttcttatttg gtatcagcag aggctctaaa tgtcagaacg 3358441 aagccttccg catcaagcca gaaagccgat acgctgcact taggagatag cctaaagctg 3358501 atttccttct caaatgctga ctgggcaaag gttaagtata aaaatggaaa aacaggattt 3358561 gtatccactc attacattgt taaagcagcg acaacggtaa aaaccaaaac aaaaacaaaa 3358621 gtgtatacat ccgctgacgg aaagagcatt aagactcttc cagcagacac aagcgtttct 3358681 tttttaggct ggagtaaaac gaataaaggc ggttttgatt ttgattgggt attcgttgat 3358741 tacggcggta cgacaggtta tatgaaaaca aaggatttac acatgacaaa ataactgaga 3358801 gggattccgc ataaatgcgg aatccctttt attatgaatt gatttgtcac attcccaaga 3358861 tatttctcag gaaatattgt cgtatgctgt gtcgaaacct tacatgatca tcgacatttt 3358921 tgttcacgct aaaaagcgga ggtgtaaata tggatcaatt tgaagcagca tatgaatcgt 3358981 ataaagcccg gcaaacaact gccgatcaag aaaatgttcc atctggaaaa gaagaaatta 3359041 ttgcggttag aagaaatgag gaagacaata ttatcgcagt gaaaaccaat acaggaagag 3359101 agctcgacta ccctactgcg ctgtcagaag caaaatcagg aaaactcgct catgttgatg 3359161 tcttccataa atacgggcgt gacattttgc gaagtgaacc ggacggcatc aaggaaaata 3359221 acctgtctga gctgccggat ttttaaacaa atacagccct gccgtatgtt ggacagggct 3359281 gtattttaaa caaaaggctg ctggatgtat tcggctaacc gttttgcact gtgagaaata 3359341 tcctctgcag ctgcataatt cacgccatag aacacatatg gaggcagata cttcatgccg 3359401 atcagattac tcgtggcctg aaatggtttc aatagctcac tgatcgagta atgatttgct 3359461 ccgcccgctt gatatttttc cgcttcgctc cctgttgata cagccagcat cagctccttg 3359521 ccatgcaagg catttccttc tgaaccaaaa gcccagccat aagtcagcac aagatcctgc 3359581 cattttttca agagcggcgg agagctgtac caatatagcg ggaattgaaa gacaatccga 3359641 tcgtattcct cgcacagctg ctgttccttc gcaacatcta tcgcttcatc cgggtattcc 3359701 ttataaagat cccgtactgt gatattgtca tgtttactca attcctcagc ccacgcctta 3359761 ttaacaactg aggtctccat atgaggatgc actgccaaaa ccaatatttt catcagacca 3359821 cacctttact gttttgatgt tattttatct aaaatcagga aaagagccaa ataaaaagaa 3359881 agccctgcta aaaggggctt tctttttttc ttttattcag ggcttccttc agttgtttcg 3359941 atatctttcg caaaatcagg gttatccaga ttcgcattaa agaaatccgc tgtgttcgga 3360001 agtctgagat tcatgttcat tttttgagaa atcgtaaccg tgcaatcctc aagcacatag 3360061 tcaaaaacgt gtccgcctga attgcgtcct tcgtcaatga agtgcaggtg atagccagaa 3360121 acggcgattc cgtttgcata agctggtgtc aagaaaccta caatcgttcc tctcacgttg 3360181 tcgaagttga aaatcggctg tgttttgacc gcttcaacca ttggcacgta aggtttttct 3360241 tgaagttcta ctgttcttgt ctgcaccttt ttaaacaatc cgtcaatgcg aattgcataa 3360301 aataagtttc tgcttggcag catgctgttg atctcttttt caaagtcttc gcgtgtcatt 3360361 ttcgcatcaa ttttgtgcgt catgtccggt gtaaagaacg taaatgaaca gaacggtgaa 3360421 cggtctccat tttggaccgg tgtcgcggtt ccgtctgagc gaagacggta aaattcgccg 3360481 tcaaacccaa tcagctctcc gtcaagcttg ttaaaggttc cgataccgaa gtctccatat 3360541 ttcggaatct ctgacagttc aaaatctccg tcatatactc cgtctaatag agaagtcatt 3360601 gttgatactt gataaatctg gctcacaggc tgatcttttt gaccacggct gagcacttga 3360661 atgttgcttt ctcgtttcat atttcccttc actcctttta tttagtgctg ttcataaaac 3360721 agtgtcgtga tgcgcagagt gctagagagc tttcgttttc atgagttccc cgaattcttt 3360781 cggaagcttg tcacttgcta aattaatgtt atcactgtag tcaaccggga catcgatgat 3360841 gacaggacct tcagcgttca tgccttgacg cagaacatct gccagctggt ctggtgattc 3360901 tacgcgcaag ccagttgctc cgaagctttc cgcatatttc acgatatcga tatttccgaa 3360961 atcgaccgca gatgtacggt tatatttttt caattgctgg aatgcaacca tgtcatatgt 3361021 gctgtcgttc catacaatgt gtacaattgg tgcttttagt cgaactgctg tctctaattc 3361081 cattgctgag aataagaaac cgccgtcacc agagacagaa accacttttt ctcccggttt 3361141 caccaatgaa gcgccgattg cccaaggaag cgcaacgccg agtgtttgca taccgttact 3361201 gatcattaat gttaacggct cgtagctgcg gaaataacgt gacatccaaa tggcgtgcga 3361261 accgatatcg caagttactg taacatgatc atcgactgca ttacgcaact ctttaacgat 3361321 ttcaagaggg tgcgctctgt ctgatttcca atctgcaggc acctgctcac cttcatgcat 3361381 atattgtttt aaatcagaaa ggattttctg ctcacgctct gcaaattcca ctttcacagc 3361441 atcgtgttcg atatgattga tcgtggacgg aatgtcaccg atcaattcaa gatcaggctg 3361501 gtaagcatga tcaatgtcag cgataatctc gtctaaatgg ataattgtcc ggtctccatt 3361561 gatattccag aatttcggat catattcaat cgggtcatag ccgatcgtca gaacaacatc 3361621 tgcctgctct agcagtaaat cgccaggctg gttgcggaac aaaccgatac ggccaaaata 3361681 ttgatcctct aaatctctag aaagggtacc ggcagcttga tatgtttcaa caaatggaag 3361741 ctgaaccttt ttcaaaagct tgcgaaccgc tttaattgct tccggtcttc cgcctttcat 3361801 gccgaccaaa acgacaggaa gttttgctgt ttggattttt gctatggccg cactgattgc 3361861 atcatctgct gcaggaccga gttttggcgc tgcaacagca cgcacgtttt tcgtatttgt 3361921 gacttcattc acaacatctt gcggaaagct cacaaaagcg gccccagcct gccctgctga 3361981 cgctatccta aatgcatttg taacagcttc cggtatattt tttacatctt gaacttctac 3362041 actgtatttt gtaatcggct ggaatagcgc cgcattatcc aaagattgat gtgtccgttt 3362101 taaacgatct gcacggatca cgtttccagc aagcgcaacg acagggtctc cttcagtgtt 3362161 cgctgtcagc aggcctgttg ccaagttaga ggcacccggt cctgatgtga ctaacacgac 3362221 tcccggtttt ccagttaaac ggccgactgc ttgggccatg aatgctgcgt tttgttcgtg 3362281 ccgggcaacg ataatttcag gtcctttatc ttgtaaagcg tcaaataccg catcaatttt 3362341 tgcacctgga atgccaaata catgtgtgac accttgctcc actaagcaat caacaacaag 3362401 ctccgcccct ctgtttttca caagggattt ttgttctttt gttgcttttg tcaacaccct 3362461 cactccttat tatgcatttt aaacgtaaaa ttttaaatat cttgtgataa gtttcactat 3362521 acactctttg gaaattgacc tccaatatcg attcgcctta tgattaatat gtaatacgaa 3362581 ttattaacct atggaaagga atgcatattg aatggagctt cgccatcttc aatactttat 3362641 cgcagtagcc gaagagcttc atttcggaaa ggctgcccgg cggctgaaca tgacgcagcc 3362701 tcctctcagc cagcagatca aacagctgga ggaagaagtc ggagttacgc ttctgaaaag 3362761 gacaaaacga tttgtcgagc ttaccgcagc aggagaaatc tttttaaatc attgccgcat 3362821 ggcattgatg caaatcggac aaggaattga actggcacag cggacggccc gcggcgagca 3362881 aggccttctc gtaatcggtt ttgtcggatc agctacatat gaatttctgc cgccgattgt 3362941 ccgggaatat cgtaaaaaat tcccatctgt gaaaatagaa ctgcgtgaaa tatcctcgtc 3363001 taggcagcag gaggagctac taaagggcaa cattgatatt ggtatacttc atcctccctt 3363061 acagcataca gctttacata tcgaaaccgc ccaaagcagc ccttgtgttt tagctttgcc 3363121 taagcaacac ccattgactt ctaaggaatc aattacgatt gaggatttaa gagatgaacc 3363181 aattattact gttgctaaag aagcatggcc tactctatac atggatttta ttcagttctg 3363241 tgaacaagcg ggcttcagac ccaacattgt ccaggaagcc acagaatatc aaatggtgat 3363301 tggtttagtc agtgccggaa ttggtatgac atttgttcct tcctcggcca aaaaattatt 3363361 taatttggat gttacttatc gaaaaatgga ccaaatacag cttaatgcag aatgggttat 3363421 cgcttaccgc aaagacaatc ataatccgct tataaagcat tttattcata tttcaaattg 3363481 tcagcagaca agaactaaag agagtgatgc aggtacatga acaatacttg caatctcttt 3363541 tttcttttgg gattcttatg gaatttttat taatttaata taatcgctta gtacaacttt 3363601 atatcagtat acgtatacat acagtacaaa tagttggcaa ggacatcagt aagcgcagga 3363661 cattagtttg attttaaaaa tgaaagatag agaggtgaag taaattattg agttcaccgg 3363721 catattcaca ttgctcgctt ttttcgtaac aatgattttt attttctgga gaccaaaagg 3363781 actaaatgaa gctatccccg ccacatttgg cgctttaatg gttttattgt gcggaagtgt 3363841 gtcattggca gacttagggg aaatcggaac aaaagtcacg ggtgcatcgg ttacaatcct 3363901 tgccactatg attatggcca ttgcactaga aagctttggt ttcttttatt gggtggctgc 3363961 aaaactgctc caacaatcca agggttcagg catcaagctt ttttggctaa ccaatttgct 3364021 ctgctttctc atgaccattt tccttaataa tgatgggagc attttgatca caactccaat 3364081 ccttttgctt gtactaaaat atttaggttt aaaaaaacat caaaaagccc catatttatt 3364141 aagcggtgtt ttaatagcca cagcctctag cgcaccgatt ggcgtaagta atattgttaa 3364201 tttaatttct ctcaaaatca ttggaatgga tctatatctt cacaccgcca tgatgtttgt 3364261 ccctagtatg atgggactca tttttatgac ttgtctactg tttatgttct tttataaacg 3364321 tcttcccaaa agcctgccag atataccggg ccattttcag tctctgcggc atagaaggta 3364381 ccatcctctt cattcgccat cagctccttt accagaacga aatcaaacaa aaatcatgtt 3364441 gtttgtgctt gcatttgttt ttctcgtcag aatgagtcta tttgcagcat catataccgg 3364501 tatttctgtt cctctagtcg ctgtcatcgg atcttttatc ctgttgagct ggagatggat 3364561 ttatttcaaa acctccccaa gagacttgtt atataaatcg ccttggcaca tttttatatt 3364621 cgcttttact atgtatgtct taatttatgg tctgcataat attggattca cagagttact 3364681 tgtgagttat tttgaacctg tggtttctgg aagcctcgcc catgcaactt tcgcatcagg 3364741 tatctctact tcagtttttt ctaatctctt taacaaccat ccagcgttaa tgatcagtac 3364801 ttttacctta actgaaatga ccctgaatcc ttcaacaaca aaaatcatct acttggcaaa 3364861 tattatcggc agtgatatcg gttcattatt attacctatg ggaaccttag caacgcttat 3364921 ttggatgcat atattaaaac agcatgatga aagtatttca tggggcgaat atataaaaac 3364981 gaccattatc atcattccgc tgactgttct ttttacgtta acatgtttat atttttggat 3365041 cagttggtta tttctttagc acagtatgaa acgaaaaact gccttctgct tttcaagagg 3365101 gcagttttgt atacactagg gaagatgcat tgtctttaga tgatttaact tccaaatgac 3365161 tggctctcca cttgcgttaa taagctcaat gatattatta gagacaccct ttaatagtcc 3365221 gactttttct ggcacctctc ccatatcaaa tatgaccaat tcaccaatat tttttttgat 3365281 ctgctcctca aaattacgca caagaggaac tttggaaggc acgaccggca attgtgagtt 3365341 gtcaagagta tacggtgttt gttcagttga ataaggggta aaccatttta aatgatgcat 3365401 agatataaaa agtattttaa atacgggtga gaaaaataca atataatcgt ttaaaacatt 3365461 tgtaacatat ccatggatcg atcgaccccc agttacataa acttcaataa actggccttt 3365521 gaccttgttt aatgtatttc tatatgaaaa agcttgagtt tctgcctcta tcattggatc 3365581 ttccggattg atcaaaaatg gcttctcagt actggtcact attttcgcct tgtttatttg 3365641 atgaagatgc aacaagggaa tataaagata attgcagcca tcaaaaataa caaaaatatc 3365701 ctgtccgata tctatgaggg tgccgacaaa ccttgtatct cctgaaatga caacctcaac 3365761 atctgtgtta aggaattgat tcaaaccttt cacgattctc ctcctttaac tgaaaaaggg 3365821 catcacttta tctgatgctc ctccattatc tattaaaatt tacgtttcca gtgatagtct 3365881 atcgttctga caatcgtttc atagctataa tcttcctttt gttttcctga actttttatt 3365941 gaacttgaat agcctggtga tcttgatgat tgataatctg aagatcttgg tgatcgttta 3366001 gatgattttg atgattgata atctgaagat tttaatgatc gtttagatga ttttgaagaa 3366061 ctttttgaac gtgacgaacg gccagatttg gatgattgat aatccgaaga ttttagtgat 3366121 cgtttagatg attttgaaga actttttgaa cgtgacgaac gaccagattt ggatgattga 3366181 tcatctgaag attttagtga tcgtttagat gattttgatg agctatatga ttttgaagaa 3366241 atgaacgaat tgctgtcctt atcattattg tcttcctggt tttgttcatt tttttgatcc 3366301 tcttttttgt acgacccttt tggacctaag ctgatgcttt ttatgtgaaa aggatagatg 3366361 cgaagcacct cttgattttt cactatagta taatggccgt cggcattatc tacaaggata 3366421 ccctcaatgg cttccggacc tccacgatta attgaaaccc atttatgagt cagactctta 3366481 aaaacctcgc ttaaatcatc agcttccaaa actccaactg gcgtctgctc ttctattttc 3366541 aaatcaggct cgtgtttact tatacttttg atgtgatgga tattaaaata cactacccca 3366601 tcctcatttg tgtttaacgc agcgtaatca tctcccagcc agaccaatct tcctttttta 3366661 gattccggac ccccttggtt aaattgaact gattggttta ttaaatgtcc gattaagcta 3366721 tgaaaatcat cagcatcgag catttcctca gtctcaattg ttgtggtgct attattggta 3366781 tcctcagtaa tacttttcac atgctccaac tgataataaa ttattttttt ttcagcttgt 3366841 aaagctatat aatctgattt tacagctgtt aattttcctt ttttagattc cggacctcca 3366901 cgatatacag taacaatttt atctttcatt gagtgcaaaa agttataata cgatatttca 3366961 ttatttgaat gatatttcat tctcctcttg ctcattcaaa ttcctcctag tcacttatac 3367021 atagatgata aacatactgc atatatacgt gtcacattta tttgttgaac taattcaata 3367081 gcctaattgt cgctttttcc gcgaataccc attttcacgc attcataaaa tacttaaatg 3367141 atctttgagg tattgtgaac ggtttttaat atactcgcag atcacatccg gctcacggtc 3367201 aaaacgctca atatcattct ttttatacgg gtccatgagg acaaacggcc taatccgttc 3367261 atacatcgcc atgattttcg gttccatata ttctattgta aaaagagatt ggagcgtttt 3367321 ttctaacagg cgcttgtagg acttgcgaaa ctcggattca tccaatatcc gggcggttag 3367381 tgtattaaat ccttgaattc ttacataatc ggcagccatc cgctctccat ggatatccct 3367441 gccccaagtc gcatcataat cccaaggaat cacctcaaat aatccggttt ccccgcttct 3367501 gtataatgcg tagttgtgga caaacccgtc atagttcgag gtgaatacaa taccagcaag 3367561 ccagcgcaaa tacttatcga catccacgtg ttttgtcact tctgacttaa actgagcttt 3367621 agggaccgta ttaattttaa aaatcatatc ttgtaaataa aaatcatctt cctcagtccc 3367681 tgttttcttt tcatatccaa gctccagcga tgttttcgtt tccctttcta aatcgctcat 3367741 cagagaaaag ttggcatcat catccaccgc ataaaaaatc gcgccatcag ccagcttcct 3367801 tttcgccaaa taatattcat ctacggattc aagttcaaga taaacccctt cattcttccc 3367861 attcatcttt acaaacgcaa actctgcctt tggagacagt gtccctagct ccgagaaaaa 3367921 atccagagac aatttgtttc tcatcaagga agggtcttta tactccgcat ttaagtgaat 3367981 ctctcgcgcg ccgcggaatg ttttcggctg ataaaaggaa atatggtatg acttcttttt 3368041 gaagtctctg atatgtgatc cccgataagc gatatcaata tccagccttt tttgatttac 3368101 cttcatcaca gctggcaccg gatcatcgtc ccatatatcc ttttttaatt cacgcaagtc 3368161 ttttggatga acaaacagct gataaagcgg taaattggat tgattcttca tccataatcc 3368221 tccttacaaa ttttaggctt ttatttttat aagatctcag cggaacactt atacactttt 3368281 taaaaccgcg cgtactatga gggtagtaag gatcttcatc cttaacatat ttttaaaagg 3368341 aggatttcaa attgggccac tattcccatt ctgacatcga agaagcggtg aaatccgcaa 3368401 aaaaagaagg tttaaaggat tatttatacc aagagcctca tggaaaaaaa cgcagtcata 3368461 aaaagtcgca ccgcactcac aaaaaatctc gcagccataa aaaatcatac tgctctcaca 3368521 aaaaatctcg cagtcacaaa aaatcattct gttctcacaa aaaatctcgc agccacaaaa 3368581 aatcatactg ctctcacaag aaatctcgca gccacaaaaa atcgtaccgt tctcacaaaa 3368641 aatctcgcag ctataaaaaa tcttaccgtt cttacaaaaa atctcgtagc tataaaaaat 3368701 cttgccgttc ttacaaaaaa tctcgcagct acaaaaagtc ttactgttct cacaagaaaa 3368761 aatctcgcag ctataagaag tcatgccgca cacacaaaaa atcttatcgt tcccataaga 3368821 aatactacaa aaaaccgcac caccactgcg acgactacaa aagacacgat gattatgaca 3368881 gcaaaaaaga atactggaaa gacggcaatt gctgggtagt caaaaagaaa tacaaataat 3368941 ctaagttttc attgtttcaa taggctgccg gcggaggtac ggaagcctat ttttttattt 3369001 gccctgtatt agatatatgt catgacataa catatgcaac ccgcatcatt tggtttcctt 3369061 taaaccattt cgttataatc aaggtatcct aacgataaag gcggttgttg ctatgtacat 3369121 atttcaagct gatcagctta gtgccaaaga cacatacaag ctattgtcag gtaccgttat 3369181 tccccgcccc attgcatttg tgacaacact ttcttcagga ggagcggtaa atgccgcgcc 3369241 tttcagtttt tataacgtcg tcagctcaga tcctccgctt ctcagtattt ctgttaacag 3369301 gacggaagga cgccaaaaag atacagcacg aaacgcagtg gagaacggag aatttgtcgt 3369361 tcatgtcagt gatgaagcca tcattgaaga tatcaatgaa acagctgcaa gcttaaggcc 3369421 ggatgaaagc gagcttacac gcacctcgct tcatcctgtt gaaagcaaag ctgtttcagt 3369481 tcccggcatt aaggaagccc gcgttcgctt tgagtgcaaa ttagagcggc atattacctt 3369541 tgacaatgat caaggcatca ctacagcaga tctgctcatc ggaagagttg tctgcttcca 3369601 cctagatgaa aaggtgtatg atgcagaaaa gggatatatt ttaacggatg aattaaagcc 3369661 tgcctcacga ttggcgggaa atcactatgc caagctgggg gaagaattca cactgattcg 3369721 tcccagctga agagaaggac tatttaaata gaagaaacta gtcaaaaaga ccttatgatt 3369781 acaaaatatc gcctgtaaat aactgaaaaa atatcaaaaa aaagaacacc cagagcaagc 3369841 tcggggtgtt cttttatgaa acgtttttcc tttttcttcg tataaaggta gattaggagg 3369901 aattggaatg acaaactttt ggattttaat gctgatcgct attaccatca gtctcgcctc 3369961 tcaatttttt ataaagaaaa aatacggtat tgataaatcc ggctggcgat ataagcatgt 3370021 cagcaataca cacaaatgga tcgaaatcac tttacttatt ttgtttgtgt tttcactctc 3370081 cttttttcca gttgaatatt tgcttctttt attttttatt gtgattgact caatacgtat 3370141 ttttatggag tggcattata gacctgaaga taaacagtat atgtaccaca ttgtagaggt 3370201 ctcccttatg tttatgcttt tgatttatgt ttgtacccta tagttattta aatccccaca 3370261 gccgctccgt ctccccgagg atcggctccg ccttggagaa agccttcttc atcaactttg 3370321 attgcagccg cttgtcccat cagcggatca tagtcaccga caacctccac gagatgcccg 3370381 ctgtctttca gtttttggat tgttttgtct gtgaatctgc cctcgactct gagaccttcg 3370441 tattcctctc cccacgttct gccccatacc cagcgcggtt cgctgattgc ctgctgtgga 3370501 tgcattccgt agtccagcat tcgggtaatg atggccgtct gggtctgcgg ctggccttcg 3370561 ccgccttgtg tgccgtacag aatttttggc tttccgcctt tacagaccat agccggcatc 3370621 aacgtatgga aggtgcgctt tctcggttca agcgtgttga catgattttc atccagtgag 3370681 aaaaacgatc cgcggttttg cagtaatatg cctgtatcac cggcagtgac tgccgagcca 3370741 aattcaaagt acaggctttg aatgaatgac actgcgttgc catccgcatc gattacggcc 3370801 gcatatgccg tatcacttcc caccggcctg ctttctgccg gtattgcgag atagccgatt 3370861 tcttctgcca attgttttgc ataacgtttg tccaaaagcc tttcaagcgg aatgtctgca 3370921 aacgccggat cagtcaggac ggcatcccga tctagaaaac tctttttcaa tgcctccaca 3370981 agcacgtgat aatactcaaa tgaaccgtgt tcgatttggg tgaaatcata gttttccaaa 3371041 atgttcagtg ttaataaacc ggtaaatccc tgagaattcg gcggcgcctg atacacactg 3371101 tatcctcgat aatcacttga tacaggcgct gcccactcac cccgatgcgc tttaaaatca 3371161 tcgattgtca tgtaactgcc gttattctgt aaatgtgaga caatccgctg agcgagatct 3371221 ccttcataaa atgcgcttct tcctttttca gcaatcaagt tcagactgtc tgcaagctct 3371281 ttttgcacaa accgctctcc cgggacaggt gctttgcccc ttctcgtgaa gatgtcagcc 3371341 gtgtaaggcg tggaagccag cagttcaata ttcttttctg tgtgacgaca ctgatcagct 3371401 gatacaggaa acccattttg ggcataatcg cgtgcgggct ccaatacatc tgcaagagac 3371461 agacgcccgt actccttcag gaccgcatcc cagctatcaa ccattcccgg cacggtaata 3371521 gcactgtcaa ttccccgcag cggaatcgcg ctttttccct tatatacatc tctcgttacg 3371581 ttttttcctg aacggccgct gccattgtag acttttactg cctttgtttc ctggtgaaag 3371641 gtcagccaaa aggaatcccc gccaagtccg gtcatatgcg ggtacacaac cgcaagacaa 3371701 gcactcaccg caacagcggc gtcaaacgcg ttgcctccct tatccagtat gcggtttccg 3371761 gcttgagaag cgagataatg cggactgacg accatttgct ttgtaccgat gacagatttg 3371821 ttcatcacaa gtcccctttt ttaagaaatt ttcttcagta tagggagcct gatttttcac 3371881 atctactgat ccggcagaaa aactgacgaa ctttcttctt ttcgcaaata ataagatatt 3371941 ttcgcattca tttcgaaaac aaatgaaaaa ttattatttc tatacgtaac ttttatgata 3372001 aaatgattgc taaaaggcta cgaaagcagg tggagcaatt gagtcatgaa tatcaaatcc 3372061 ccaaccttgt acttgatgag actgataaac aaattctcac gattttgcat gaagaaggca 3372121 gaatttctta tacggatctt ggcaaaagag tcgatttgtc acgggtcgcc gttcaggccc 3372181 gtatcaacca attaattgaa gccggtgtta ttgaaaaatt caccgctgtc atcaatcccg 3372241 ctaaaatcgg catccatgtt tccgtgtttt tcaatgtcga ggtagaaccg caatttttag 3372301 aagaggtcgc tcttaagctt gaggaagagc ctgcggtcac cagcctttat cacatgacag 3372361 gcccgagcaa gctgcatatg catgggatct ttaccaacga tcaagaaatg gaagaattct 3372421 taacaaaacg gctgtatcca ttgcgaggcg tcgtcagtgt tgattgccag atgctgatca 3372481 aacgatacaa aagccgtatg ggaatgaagc tgtaaaggag agaaacaaat gaaaaaccat 3372541 ccttatcggg atatgacggc cgcaatggtt cgcaccggca tattagggtt cggcggcgga 3372601 ccttccgtga ttccgctgat ccgccatgaa gcggtcaata aatataaatg gattgacgat 3372661 gatgaattcg gagaaatatt agcaatcgct aatgcgcttc ccggaccgat tgccaccaaa 3372721 atggctgctt atctgggctt taagctaaaa ggcacattag gtgcaattgt ggcgatcctc 3372781 gcccacattc tgcctacatg tcttgcgatg gtgggcttgt ttgcggctgt aaatgtgtta 3372841 agccattcag caattgttgc aggtatgatt ggtgccgtca cgccggtaat tgcggtcatg 3372901 ctcggaatca tggcgtacga gtttggccaa aaagcgctta aaggtttcgg ctgggttacc 3372961 ggcatcctgt tttttatcat cgcttttatc ggcctgcaaa ctttacagat taatcccggc 3373021 ctggtcatta tcattttctt agcttacggg gcgtttcatt ttaaactgaa agacaaaatc 3373081 acaaataaac attcaaaaga taaaggaatg tcagcctcat gatatcgatc tatttattta 3373141 tggcgttttt tatcgcaaac ctactgggat atggcggcgg acctgcgtct atcccgctaa 3373201 tgtttgaaga agtcgtaaac agatacagct ggctctcaaa cgatcaattc tcaaatatgc 3373261 tcgcacttgc gaacgcattg ccgggcccga tcgccacgaa aatcgctgcg tatgtcggct 3373321 acagcgcagg cgggtggccc ggcttcctaa ttgccctgat cgcaaccgtc gtaccgtcgg 3373381 cgctcgcatt gatcgtcctg ctgcgcatca tccagcgctt ccgccaatca cctgtcatca 3373441 aaggcatgac gctgtccgtc cagcctgtca tcgcggtcat gatgctcatt cttacctggc 3373501 aaatcggcgc agacggcatc aaagcgatcg gctgggtcca atcgatcgtg attacgggaa 3373561 tttcgctcct tgccatgaca aaattcaaaa tgcatccggc atttttgatt attgcggcgt 3373621 ttttatatgg gggccttgtg atcccttatt tatagaaaaa agcacctgga caggtgcttt 3373681 tttattttag cccagaaatg ccgtttgata tgacagctgt ttcttctcct gcgtcactct 3373741 tgatcatgtg cttgacttgc agcgtggttc ctgccattct cacagattgc ttcaactggg 3373801 acgaattggt ttcaacttgt atccaaacag gaggctggac cttccaaaat aaatagagtg 3373861 caagaatcag caagccagca atgaccgaca gcaaaaactt catatcgcat cgcttctttt 3373921 cagtaagcgg ctcgcagcgg acagcgcctg atgatcacga agaatatcgc ctggacgatt 3373981 gccttctccc agcacatagc ctttaaagga cattcccata aaatgaaaaa tatgttcgaa 3374041 ttgctgaatc agcggcagcc cttttatttt tggattgtct ccgcccactg ctattacata 3374101 tgcctgtttc actgacattt gctgtttaaa atcaggaaat ctcggatctc tcaacgtctg 3374161 tgaccagcga tcaataaaca gctttaatgt ccctgacatg ccaaaccaat aaattggggt 3374221 ggcgaatata agaatatggc actgcaatat ccgttcaatg atagaatcgt agtcatcttg 3374281 aacaggacga aagccgcctt gggcgtgacg cagatcttca attggttgaa ttggatattt 3374341 ctgcaaataa atgtgctccg catcgaatcc ttgaacagcc ttctccgcaa gaacatccgt 3374401 atttccgcca gaccgagttc cgccgttaat aaccgcaatt ttcatgatgc atctgctcct 3374461 ttgtttacga atgattttct tcatcatata atggattcat caatcaatac agatgattat 3374521 ttcgattaat ccaatcgcta aaaccgattt agaaaggaag agaacaagtg gaattgaagc 3374581 agctgatcac ctttattacg gcggctgaac atgtaaactt caccctaacc gccaaaatgc 3374641 ttaattatgc acaatcaagc gttacctctc agatcaaatc acttgaagaa gaaatcggaa 3374701 cgcctttatt tgaacggctc ggcaagcggc ttatcttgac agaagcagga aaaacgttca 3374761 aatcttatgc acagaagatc attgcgttaa cagaagaagc gaaaatggcc acaaatcaag 3374821 taagagaaac aaccggaacc ttaaaaatcg gggcgacgga aagccagtgc acataccgcc 3374881 tgccccctat cataaaagaa tttaaacagg cttttcccca agtaaagctc atattcaaac 3374941 catatatctc caatgaacaa gcgaaagaac agctcttaca gggccagctt gatatcacct 3375001 tcatcttgga tgtaaaccgg atggaagacg cactgcacgt tgaatctttg attcaggatg 3375061 agatcaaaat ggtggctgct aatgaccatc cttttcctgc ggatttacca gtaacattga 3375121 aggatcttca aaacgaaact cttctgctga cagaggacgg ctgctcgtac cgcacgctct 3375181 ttgagaacaa tttgcatgac tccggtatct atcctaacaa attggaattc gtcagcatag 3375241 aagccatcaa acaatgcgtg atggccggac ttgggattgg aatcttgcct gaaatgacag 3375301 taaaagatga tattgcagca ggccggatga aagaactcaa ttggcagagc gattgccccg 3375361 ttttcactca attagcatgg cataaggaca agtggatgtc tgcgccatta aaggctttta 3375421 tcgatttgac acggaaaaca ttcaaataaa acctctccac aaggacgaca aggtttttga 3375481 gaccagggca cacacataca aaaaaaacac ttgatgactt agagccccaa gtgttacacg 3375541 tgatttttct gataaaacgt tcgcaaaaca tgcgtctcaa ggtcagccag gcggacaggg 3375601 atcggcagcc tgctttcttg attgatcaag ctcatcgtga tctgatagct gctgtctaaa 3375661 tcaatataat taccgcaaga caagaaaata ggcttcacgt cccgccgcgt tcgcagcgcc 3375721 cgtccatata cctcgccgtc aatgataata tcggtgtatg cgcctacttc aatttcaggc 3375781 gtcacgaaat cgcagccttt gattttgaga taggttttcg ctatcccaat cgtcggcttg 3375841 cccagaaaaa aagccgcatg ggtggcaacg cccatatgat tgtaatgcag atatccgttg 3375901 ccatcaaaca agaagacatc cggctccgtc tccagctttt tcgccgcctc gatgatcaag 3375961 ggcagctcgc gaaacgcaag aaaaccggaa acatacggca cgctgattct ccccatgctg 3376021 tgcacttttt caatgacttc ttttgtatca gcgtcaatta cgataataca gcacactccg 3376081 tatggttctc catcctgctc ccaataggcc aggtcgacgc ctgcgcaggt gttgatggag 3376141 tctggatgga tcgtggggga taggttgata cgatttttaa ggttaaattg cacttgtaaa 3376201 aagtcttgtt cctttttcat atcaaattta tgcacatcaa ataccttcat aacgattgct 3376261 cactctcgac ctaaattaat gtgagtctct cttctcgatt ctagtatttc aaaatgagga 3376321 ctatctgtat ctatctcgta cttatttaat agattgcctt cttcatccca attcttttca 3376381 gaaattagta tggaatgctc atactgttgc tcactttttt tcctgccatt ttcaaaccaa 3376441 attatgctta taccgtgcaa ttgcccatat cggtattctt tttcactttt tttattcccg 3376501 ttttcataaa attcacatgt taaaccatgg gccagaccat tcttatattt agtaaaatag 3376561 atgatttgac catttggata taattcgtaa gccagccctg taaacggctg gccattttcg 3376621 tcttcaggat tatctaaaat ctcatcactt accgaagaga accataaatc ctcaaagtcc 3376681 actccctttt cttttatact cttcatatca tattcatttt ccatacttta aagcctccgg 3376741 tatataattt gtattttgag ttatatattc acaatgtgga catctaggca ttgggacacc 3376801 ttctggcatc tttttattta ttttcctagc acttactaca tataccatta aatcttttaa 3376861 atccgcatca ggtctttgaa gtaacgcttc atttagagca ttaacttcgg catgagaacc 3376921 cgcccctgac gtctttatat aaccttcttt aagttctgta ggcatattta caattctatc 3376981 atgaataagt ggatgtagta ccttaggtgg cttcccatct atattgttta ttccaaaata 3377041 ataattgcct gtttttttgt ccaatacacc agctaccgca gggcctcttt gttttttagt 3377101 tagaccagaa gatttaattc tactaagttc gtttagtact tctgccctta gatttattcg 3377161 atggtgaaga tcttctttag acaatacacc atgcttattt cttaaatatt gaagcctagt 3377221 ttgtttttct tcagtagtct tagcaatatt gctaataagg ctttcattac tcactttatt 3377281 gacatatgga gcattttttt ggtacaaccg atcaaagtag tgtgccaatc ctgctccacc 3377341 aataatagta atagcttcca gcgccccttg cttccgcttc tcctcagaca ctttgtttcc 3377401 gaacatatcc cggcctgtga cagcttctga gaatccgttt gacgcaacaa ggccgtatgc 3377461 gcccatttct gtcattttga gaatgtctaa ggatttgcct gttttgtagg cgtctaatgc 3377521 gtgttcagca gcgatagctg cttttccggt tttgtagatg gcttttccgc ctttgaaggc 3377581 ccggcctgcc cagccgacga ctggtatgaa tccggcagcg gccatagctc ctgctgtcac 3377641 acgctccgcg gtggagagtt tttctccggt aaccggatca acgccttcgg ttgctctttt 3377701 ataatcataa tagccagtga cttctccagt aaagttgcaa actccatccc atgttttttc 3377761 gtaccacggt ttgtttgctt cttcctcggc tttttcctgg agccgtcttg cttctgcttg 3377821 ctgggttttt gcatcgatat aggttgttcc ttgattttct acttcaatga cgcttttgta 3377881 gacttcattg ctgtggaagg cttttttgtc atagtacata ggggatgcgc tcttcccatt 3377941 gctggtggcc tgcatgagaa cagaatattt ggtgagcact gcgttgtcca gagattctaa 3378001 attttgatat tcagtggtca gggattcatc aagcttatcg acagctgtga ttgtatcacg 3378061 tctgattttt tgggcatcgc ccatcttatc tgcatagtcg tcaagcgtgt acatgtcgag 3378121 atcaataata tcgctgatgc ctgacaaaat agaatcgatt tcttctttat gagcggagac 3378181 aatctctgag gctttcaggt ctccattggg cagctcatga tccaaaaaag aagtttccac 3378241 atatgaatca ttcagttctt gatctttaat atctcctgaa atgccgttta aaaacgcaat 3378301 ttgagcagag acaagcgtca gccagctgtc tacgatttct gcctgtccct gaaaaaaatc 3378361 tttaatattg tccgcgccat ttcctttaaa attatcgcct aaatcggcaa ctccctgaaa 3378421 cgcttttttc agcgtattca gctgctcttc aagcgtctca tattgctttt ttctgctctt 3378481 cgcttcttcg attaaagatt ttgattcaaa tactttactc atcgcactgc cctttctgtt 3378541 ctattttacc gctatcgcct cgtcctgctc tttgagtgaa tctacgttat cctttgtatc 3378601 ctcgatattt ttctgtaccg cttttttgta atctccgagc atggttttga tgttctcctc 3378661 acgctcatgg tattttttcg tataatcgag gctgtttttt ccgttggatc ctgcggcgcc 3378721 gattgatacg tcagcaagcg catctttgac agaatctaat gttttgatga ctgtgtcgta 3378781 cttcagctta atttctgaca taaaaaaaga tcaccaccat tttagtttac taattgtatt 3378841 tccgacttct tccgcgaact cttctccctt tttaagaaga tctgctgcac catttgctat 3378901 gaacaattcc gatgcatatt tagctttatc ccattcaaga tcaaaaattt tcccgttaat 3378961 cgaagccata tactcgttat atttatcatt cacaatctta gatgcttccg atttcgcctc 3379021 ttctcttccc ttgtcgaaat catcggcttt tgttcccgtc caatgcttgc ccaattccgg 3379081 tttcacaatt tctttgattt cagtgattgc ctcttcttgc agtgtgtcta tgtccttttt 3379141 tgcttttttc agcttttcga tcttgtcttc cacgtctgaa atttttccgt tgagcgaact 3379201 tttgatatcc gctagcatac tttcataacc catctgaatc acctcttaat actcaaaaag 3379261 tcgtatggag gggctgatga agatagactt ttccatactt tatttccata tattatattt 3379321 taaaatagcc agaaggcggc ttaaataggg taaatggctt aatttaggca tataacgctc 3379381 ttgaaatgta ggtatttgat cttgtttttg ttcgttatac agctaataaa agcgttttat 3379441 aaaatgaaat cacctaatgt catagttata aaggcacttg aaagaggcag atgttgttga 3379501 tctgcctctt tcggcgctga gcttattgtt catgtttatg ttcttcatct ggtcggccat 3379561 gtctgatttt gtcatttggc ttctattatt ccccccttct gaccctttgg atcaaaagct 3379621 tgtattagct gcagtcccag ttgtacagaa cgtttgaaaa gtcttttttc cttagatctt 3379681 caggtgtgat gaaaaaattg gcgatgccga cgtctcccca cattgaatcg atatcatcgt 3379741 ctgaatcaat ttgtaacagc atgatggtgt gttctttata tgcgtattcc cggggatcat 3379801 gctgggtaaa agaagcgtat ccgccaattt tatggccaaa tccgttttca gccagttcat 3379861 tataaatgtc ttcttcatcc tcgccgaact gaccaaagaa ctccattgtt tccatgcccg 3379921 tatactgctc aaattgaaaa tctgtaggca gcacccattc cgaagatttc acaggctcga 3379981 ctgccgcttc tgataaaatc ggaaaatcac attcgcctgt gccaataaat gaaaaatcag 3380041 aaacaagctc gtcatcgttt tctacgatat tttcaaaata gatcactctg aaattctttt 3380101 gttcacatcg atcgtcaaaa ttcaatccat agacgtcatc atgaacagaa atgtagaact 3380161 gcaggatacc tgaagaaggg tagccgtcaa gctggggaat gtgcgagaaa ttaatctgcg 3380221 ccagaagttt catcggctgt ccattttcgt cagtcggata tgtttcatgc ttggggaaat 3380281 agggatcacc ggcaattttg ctgtcatatc gtcctgtttt cccctttctc acattcagtt 3380341 tcacgtattc tttcgctgat ttctccagca agtcgcggta cggtctcatt ttttcgggca 3380401 gatgattcat cagattctct ccttttccgg catctccaag gttttatttt ctggttttct 3380461 tctaatgttt ttcaaacgaa tgtttaaaga agccctactt ctgcataatt ttccaaacaa 3380521 tagttaaata gtagcaaatg tattcagcac cccgcaatag atgaaaaaaa gactggtgcg 3380581 caaccagcct ttctttttca tctattgaat tgcacctgac ggaacaaccg ccttccgtcc 3380641 gacagaataa tactccactc ctgcagccaa agcctcatcc aatgtgtagc agtttctgcc 3380701 gtcaaatatg agcggcgttt ccatcaaatc ctgataagcc gctaacggga attgtttaat 3380761 gtcagcccag tcggttaaaa tcatgacggc gtcagaccct ttgacagctt cctcgatcgt 3380821 ctctttatat tcaacagctt gcgggagaac atgctttgca tggctaactg caatgggatc 3380881 gtaggctctg atacgggcgt cgagcgcagc gagacggtct gcaataacaa ttgacggcgc 3380941 ttctctcata tcgtcggtat tcggtttaaa tgacaggcct aaaagggcaa tcgtttttcc 3381001 cgtcacccca ccgagcctgt tcagcgcttt atcaaccagc atcgcctgct gattgttgtt 3381061 gactttgata acggatttca gcagttcaaa atcatgctcg acattgccgg caatttgcac 3381121 gagggcgttt gtgtcctttg gaaaacaaga gccgccgtag cctatgcccg cttttaaaaa 3381181 ctggctcccg atccgcttat cctgtcccat cccgtatgcg actgcttcaa tatcggcgcc 3381241 gaccttttca catatattcg aaatttcgtt tataaaactg atcttagtgg ccagaaaagc 3381301 atttgaggca tatttgatca tctcggcgct tctgatatcc gtttggtaaa tcgggatttg 3381361 aaacggacgg aagagctcct ccagcgtatt tgctgttttc tcatcggccg tcccgatcac 3381421 gatcctgtca ccatgaaagg tatcatagat cgccgacccc tcacgcaaaa attccggatt 3381481 ggatgcgacc gaaatactga caggctccgc tagatgttca gtaatcagtc cattaatcaa 3381541 atcgtttgtc ccaacgggca ctgtgctttt cgttaccacg actgtatctc gtttgacatg 3381601 ctttgcgatg cgtttggccg catctgtaat ttgctccaga ttggcgtgcc cgtcgctttt 3381661 ctgcggtgtg ccgaccgcta taaaaatgat gtctgcctgt gccaagcctt tctcatagct 3381721 cgtttcaaag ttcagccgtc catcagctgt attttttctc atcagctctt caagacctgg 3381781 ttcaaatatg ggggaaatgc cctttctcat ttcatcaatc ttgtgagcgt caatatcaat 3381841 gcaggttaca tgatgtccaa tctcagaaag agaaacacct gtcacaagac cgacatagcc 3381901 tgttccgatg actgttatat tcattgtttc cctccaacag ttaaattgct gctttgcagc 3381961 ttccgtaata tcgtatgaga acatcctatc atgaatgcga atgatctccc gcatagcctg 3382021 tcgggtacag cctgtacaga tttctgaaat gtgattcaac catacaatac actattatat 3382081 cgctctcaaa aagaaagtgg tgaaatgaga atcggctgtt aaaaaaaacc aaacaatttt 3382141 cttcttttga ccggctgcgg aggctgtctg aagatggtct gattccgcag gagaagctct 3382201 gcattttccg tcagcatata aggaagttcc gagccgaatt ctttctctag aacataaaga 3382261 gcctcttgag tgtgaaaatt tctcgttttc acattatggg catctgaggc tacgaaatgg 3382321 atcaaattgg cttcaaccag ccggagagaa aatgctttca gctgcttgcc gaagatcccc 3382381 gcaagacttc ctgaagtaat ctgagatgct gctccttttt ccacaagatg atacagcaag 3382441 gacgggtttt cgcgaatttc cctgttgcgt tcaggatggg cgataaccgg aatatatcct 3382501 ttcagctgca aatcataaaa aagctgctcc gcatatcggg gaacgtgatc aaacggaaac 3382561 tcaatcaaga tgtattttgt atcattcagc gaaagcagct gacgtttggc aaggtcttgt 3382621 tccacctcgc cgtagattct gatttcctgt cccggaagca catgtaaagg aatgtcttct 3382681 ttgattaaac gtttgtttaa ctgatctgct gcttctctga ctgcggctgg ctcgttttta 3382741 tacacaccgt tgttatgatg aggtgtcgca atgatcgtcc ggattccctg acgaacagct 3382801 gctcttgcca tttctatgct gtcggccgaa tcacctgccc cgtcatccat tgcgggaaga 3382861 atgtgacagt gaatatcgat catgtcctag cccccttttt tcgcaaaaat aaataacggg 3382921 cacgatgcac gttatttatt tttgcatgaa attgtccttg gttccgtaat atccgtattc 3382981 agagtgcttc gaaagctttt tgccgttcat aatcgcccca aggagcttgc ttttgcacgt 3383041 tgcaagcgcc tctttcgctt ttgcggcttg ttctttttct gttttcccgc ttgaaataac 3383101 cagaacagaa ccgtctgcca cgttgcctaa aatctgtgca tctgctacgg caagaatagg 3383161 cggcgtatca aaaatgacca tatcatatgc cgcacacgct tcgtatgcaa gctccttcat 3383221 ccacttcgag gagagaagct cggccgggtt tggcgggatc gggccgctcg tcagcacgtc 3383281 aagatgtttt tcattcgatg cttgtacagc ctgctccata gagcttttct ttaataaaac 3383341 agatgttaag ccaaccgtat tttcaagaaa aaaagccgta tgtactgttg gttttcgcaa 3383401 atcagcatca atcaggagca ctttttttcc ctgttgggcg aatacgacag ccaggttggc 3383461 ggccgttgtt gattttcctt cccccggaca agccgatgta atcatgactg atttcatttg 3383521 ccggtccact gaagcaaatt ctatattcgt gcgaatcgtc cgatattgtt cagagttcaa 3383581 ggatttcggc tctgtcattg caatgacatt tctctgcatc cgcgagcctc tgttttttct 3383641 aagcgccaaa atgtccactc cccgtttttt cagattggaa accctgtaag gtctttgctg 3383701 ttttctgctc attcgcaatg gtggaaactg tccctaaaac aggtatgtcc agcaaggatt 3383761 cgagctgctc ttccgatttg atcgtattat ccaaatgctc aagcaggaag gccagtccga 3383821 tgcttcccgc caatccggcc gcaaacgcga tggcaatgtt tagtagcggc tttggcgata 3383881 caggggacgg gtgttctgaa acctcggctt ttgacagaat gctgacattg tcaacattca 3383941 taatggatgt gattttgtct tgaaaaacag atgctatagt attggcaata tgagccgctg 3384001 tttccgcgtt ttcatccctg actgatatgt tgaccacttg ggagtcctgt tcgctggata 3384061 cggtaatttt gtcattcagt tcttgggatg tcatcgacag gcccatttct ttaatgactt 3384121 catctaagat ggcagggctc ttaatgatga cattgtacgt attgattaac tgaagattgg 3384181 tttggacatc gttaaattgg acttcttttc gttcattttt cgattggttg accagaatct 3384241 gagttgaatt ttcatagatg ggtgtaagtg cgaagaaact aatgagtccg ccggcagcag 3384301 tggcagccgc ggttacaatc ataatcaaaa gtatgcgttt tgttaacgtt gataatatct 3384361 cttttaagct tgtagattct cccatgatac ctccaaatct cttataacat ccttttccat 3384421 ctacgattat acaacgttga aaccgcattt ctccagcttt tcacgtgaca taattcgaca 3384481 tttttttaca atgcgttatg ttagtacttt ttatgtaagc gctatattta ctgtgttgac 3384541 agtgctgtct cattttctct tattcgggca gtcacgttct ctcgcataaa aaaatcccgc 3384601 taaaggcgtg cgggattttt atgttgcata tccattttta atatgagaaa tcaaattttc 3384661 aagcatttcc ttcgtcgtca tctcagatga ctgctcacca atttcatgtg catgcatcaa 3384721 aattttcaga aattcttctt gattcaattt cttttcactc atcttttttt tcctttcagc 3384781 ttccattaag ttgaaaacac gattattata tgatgctggt tatcaatttg caatctctaa 3384841 tacatcattc gacacatcct attttttatg tcctttttta ggaaaaactt tttaaggccg 3384901 atgtgttgcg atataataga gaaattggat ctttttatta cgtgactcgg ttaggagcga 3384961 taatcatgct tcagaatatg atttccaaag acgatgtgct ggcatctgct gaacagttaa 3385021 aagaacttct tccttacaat gaggaaaatg ttcagctgat caaaaaagcc cttattttat 3385081 atcggcagga ttcagtctat cgtttacaag cagtgagtcc gacggaagtt acggcttacg 3385141 tgcaggatgt tgtgcctgtg cgggtcacat tgaacttgtt tgtcatagtc aaaagcggct 3385201 gttcatgtcc gtccggaaga atctgccgcc atatgctggc tgtgttttta tatgtatatg 3385261 caatgttcga gcgagtgggt acttttacag agtattggct ggagagggaa aagcttgagg 3385321 aaagcaaaga gctcgtccgc cgccagtttc aggaaaaggt gctgcctaat gaagaatcac 3385381 tttcaagctg gcttgctttt tttgattcag agttttctct ctggcaggca cgtacgccag 3385441 aaggcagcca aaacatgcag ggcctctatt acggctacct gtccgcatta aaaaaacatg 3385501 cgccgaacaa gccggagctg aaaagcctgt atcagattca ttccgcgatt gcggtttggc 3385561 ttcgcatgtt cacattgatt gaagcgggca agctaaaccc cgaacaagat ttttattccc 3385621 tcaatccgta cgttgaacag ctgatggata caatctacag ctctattgat aaattaaaaa 3385681 cgtacgcgct gtcttttgcg cttgatccgt ttttggataa aacaccggat gttatccggc 3385741 atttgctgtt gaaagaagaa attttccaat atgaacgcat ccgcgtcttc ggtgaaattt 3385801 ggagtgcgct gctgtcgcgg ccaaaatggg tggcacgcga acaggagata ttgaaaaaag 3385861 aagcaggacg gcgtttttct cccgaattgc aattcgggcg cctgcatttg gaattcctgc 3385921 aaaaaaatga tgacgttatt tttgaggaag cggatcaatt cccgccggaa gcgctccctt 3385981 atacattcca atggctgagt gaaatgactg ccaagaagga ctggaaacgg cttaaaacat 3386041 ggtaccagca aattgaacca attgcgatgg gttatacgaa gctggataag ccgtttaaag 3386101 agattcgcga tgtgatcggc gagctgttcc ttctgttgaa tgcctatgtg cagcaaacca 3386161 atgatcaagc gctgtttgag cgctttgccg cgggctgtct gccgtatacg ttcacagaat 3386221 acagccatca tttatatgaa aaaaaacgct atgccgagtg gattgaaatt catagccttg 3386281 tcggcttttc catcaatgaa atggataaaa tgatgctcaa ggaaattgca gcgagcgacc 3386341 ctgaggcgct tataccggct taccatagag aagtggcttt tttcattgat cagaagaacc 3386401 gtagctcgta caaggaagcc gcccggtatt tgaaaaaatt gcgcaccctg tacaaaaaag 3386461 cgaaaaagca gaaggtgtgg gagcggtata ttcagctgct gagctcgcat tacaagcgcc 3386521 tgcgtgcgct tcaagaagaa ctgcagaaag gaaagttgat tgatggcgag tcttaaagaa 3386581 attctcatcc acgtcgaaca aatggaagat gggtcattta cgctctcagc ctttgatgag 3386641 aatgagcagc ctcttcccta cagccatatg aaaaagcatt tgttccaatg gcatgaatcc 3386701 tcattttacg gaacctttct agaggatgtc agcttcatcg ggacgactgc tgtccttcta 3386761 tctccatgga tgactgtaga gcttctcggc aaaaactcgt tcaactcatt cagctccgtg 3386821 cagcttacag aagaaacgga gccgctgatc gaggcggcat cgaccatcta tgaatttatc 3386881 gcggacggcg attttatgcc tgactatgac gcatggacaa acggtgtttt tcgctggaag 3386941 gaccgcgata atatactgga aggctttact gcggaatggt tttccgctgc cgtacaggat 3387001 tacatccagt acgacgatga cctgcgggag aaatgggaac atatcaagga aaaatcgcct 3387061 gcggttacga cattccgtgg ccattttctt gatgaagagg attttctgga aggcattggc 3387121 tggattgacg atcaatctcc atttactgtc ggcttgcgct taaatgaacc ggactttgac 3387181 ggagacgaat ggaagatcga gatgttttta cgcgataaaa agagcggtgc tgtagaattc 3387241 tttgacggac tgaagagcct caaaaaatcg tggcaggcgt acagcgataa aatcgcgcgt 3387301 gagcaggacc gctttcacag aacggttccg tggctgtcgt ttgattccgg gacaacgctg 3387361 atctcggagg aagaagcctg gatcttcctg tcagaagcaa gtgagacgct tgtcgatatg 3387421 ggggtagaaa tcctcctgcc gtcctggtgg cagattgtca gagacagcaa catgatgctg 3387481 aaagcaaagg tgtcttcctc cccgcgcggc gagtcatttg tcggcatgaa tgcactgctt 3387541 gatttcaact ggcggtttgc gacaaatgga attgaactga ctgaggctga atttaatgag 3387601 cttgtcgcca gcaacaggcg ccttgttaat atccgcgggc aatgggttaa aatcgatccg 3387661 cagtttatca aacagatgaa acgcctgatg gaaaaagcag aatcagaggg actccacatg 3387721 tctgatattc tggcgcggga gctaatggat cagcaggatg gcggacttga ggattcggac 3387781 ctgattgata catctgcttt tgccggcatt cagtttgatc tgtctaaaca gctcaggtca 3387841 ctgattcgaa agctcactgc cgcggaaaac ctgccggagc acaaagtcag tccttctttc 3387901 aaaggaacgc tccgccctta tcagaaatac ggcatgaact ggctgctgtt tctgcgggaa 3387961 agcggttttg gcgcctgtct ggctgacgat atggggcttg ggaaaacgat tcaaatgatc 3388021 gcctatttcc ttcacgtgaa ggaaagcggc cgacaaaaaa cgcctcattt gattattgcg 3388081 ccgacatccg tacttggcaa ctggcagcgg gagcttcaaa cctttgcccc tgatctgtct 3388141 gtcgcgctcc attatgggcc gcgccggcca aagggtgatg atttcgccgc gcattatgaa 3388201 aacgcagacg tggtgctcac ttcatacggt ctgtcacatg ccgatactga agagctttct 3388261 tctgtgacat ggaacacgat ctgccttgat gaagcgcaaa atattaaaaa cgcgcatacg 3388321 aagcaatcac gcgcaatcag gaagctgaag gggcttcacc atatcgcgct gagcggcacg 3388381 ccgatggaaa accgactgac tgagctgtgg tctatttttg acttcatgaa taaaggctac 3388441 ctcggcagtt tgaccggctt ccataaacgc tatgtgctgc cgatcgaaaa agaccgggac 3388501 gaaaagagaa tcggacagct tcagcaatta atccggccat tccttctccg ccggacgaaa 3388561 cgggatgaag aggtcgcgct taatcttcct gagaagctgg aagaaaaaga atttatccct 3388621 ctgtcagccg agcaggcatc cctttatgag cagctcgtca aagacacttt tgaccatatg 3388681 acatccctga ccggcatgca gcgaaaagcg ctgatcctca gcatgcttgg acggctcaag 3388741 caaatatgcg atcatcccgc gctttattta aaggaagagc aaaccgagct gctggccggc 3388801 agatcagtca agctcgaaaa attgctggaa ctgatgacag cgatccgcgc ccaaaacgaa 3388861 agctgcctga ttttcacgca atacattcag atggggaaca tgatgaagcg gctgcttgaa 3388921 aaaacgttcg gggaacctgt gcaattttta aatgggagtc tctccaagca agagcgggat 3388981 acactcgttg agaaatttca aaggaaagaa tatccgacac tgattctttc actcaaagct 3389041 ggaggcaccg gacttaattt gaccgccgcc aatcacgtca tccattatga cagatggtgg 3389101 aacccggcgg ttgaaaatca agcgactgac cgtgcatacc gcataggcca ggagcgcttt 3389161 gtccacgttc ataaaatgat tacgacagga acaatcgaag aaaaaattga tgtcatgctt 3389221 gaatccaagc aaaccctgaa cgatcaaatt atccaaagtg aaaactggat taccgagctt 3389281 tccacacagg agctcgaaga attgtttaca ttaagcgcta cagcgcaata atcatgacta 3389341 aaaaagctgg ctctaaaaga gccagctttt ttccgttcat agccgtcacg ccgaatttcc 3389401 aaaaaatccg ttacgccggt tatcaacagg gtgcgctttt gtggcagcac atatacttac 3389461 aacaaatgtt tcatcatatg tgcgacaccg tgttcgtcat tggttaaggt gacagcatcg 3389521 gctatcgatt tgatgtcttc ccgggcattg cccatcgcta caccttttcc cgcagcctcc 3389581 agcatcgatt tgtcatttaa actgtcacct acagcagcag tttcctcgag cggaatattc 3389641 agctgttttg caagcctctt cagcgcctgc cccttggaag ctttgcggga agaaagctca 3389701 aagttgtgct cagccgaact gacaagcgtc aaatcttcgg catgctcata tcttttccag 3389761 cctgcctcaa gcttttcttt gaagaaagaa aagccgagaa tattgtaaaa atcgattggc 3389821 tcatcggctt caaacagctc ttgaaaggag ttaatgtaag caaagcccga ttggctgtat 3389881 tgcacctcgg ccgcctgctt aaggacagaa agatccgctt ccggatttgc gcttctgaat 3389941 ctgtcgagct caacatcaag aagttctctg ccgttttgcg gcgtataaat cgctgaacct 3390001 gtgaatacct cataataata gttttccgac tcaagccatg agagaatgtc atacgcccgt 3390061 ttcttatcaa tcgtttcgtg atgataaagc ctgccctcgg gatcgtgaat gacggcgccg 3390121 tttgcactga tgacccatgt tttgatcccc agcggttcaa agattgacat gacgtcaaaa 3390181 tgagcgcgcc cagttgacac caccacttca atgccgtccc gctgcgcctg ccgcagtgcg 3390241 ttttcatttt ccaagcttac ctgatgcttg ctgttgagta aggttccatc taagtcaatc 3390301 gcaattaatt tcacgtttgt cagtcctttc cttcatcctg ctctgtcacg agaagctcaa 3390361 cgccgtttcg gtcaagcaag tcacaaaatg cctgattcgg cagcctgtct gtaatcaaga 3390421 ggtcgatttc attcagctcc gcatactgat aaaaactggt gctgcccagc ttagaatggt 3390481 ctgcaagcgc aattacctgc tttgcctgct gtatcatttt ccgcttcacc atgccatcct 3390541 cttcatgcgc aattgtaatg ccatgttcgg aaatgccgac cacaccaatc agcgctttat 3390601 caacatggta gcttgagagc ttttcaatca cagaggaccc gtacagaaag cggtgctcct 3390661 tttccagctt gcctcccagc agataaattt caattccctc tttatcggac agcacatccg 3390721 caagattaat cgaattggtg attacggtac aatcaaccgc attcaaatgc tttgcacatg 3390781 cctgaacagt tgtagaggcg tctaaaatca cccggtctcc atcatgaata agcgatgctg 3390841 caagcctgcc gatcttattt ttttcctcag acactgtttt caggcggccg gaatagcttt 3390901 gaattttctg atgcacagtc ggtaaaatgg cgccgcctct tgtgcggatg atggcattct 3390961 gttcctcaag tttcacaaga tctcgtcgcg ctgtatccct tgacacttgc aggagcgtac 3391021 agatctgctc cgttgtaatt cggttatgct gttttaaaaa atccaaaatc gctactaatc 3391081 tttcttcttg gtacacgccc tcattccttt tctcagcaat catttataag taattataag 3391141 tttttatttg attttattca acattaataa gtgattttaa gtaaaaatgc gtcgagagaa 3391201 ccaatttttc ctaagtaggc aaaaagaaag aaccagtctg gtcgactggt caattttgag 3391261 gggatgatgc gaagatccgg ataatagtga atggatagat aacgggagga gcaggggtgt 3391321 caatcagcag ctttttcccg gggtttaggg tccataaaac gaacagtgtc agccaacact 3391381 tctgttacat acacgttaac gccttcctcg ttttcatagc ttcttgtctg aatccgtccg 3391441 cttacgccga cgagagaacc tttttggcaa tacaacgccg tgttttcagc tgtttttctc 3391501 caaagtgtgc aattgacgta atcagcttcg atttcacctg aagcattctt gaagctgcgg 3391561 ttcaccgcga gcgtaacatg tgcaactgcc gcaccggcgg aagtgtagcg aagatcagga 3391621 tcttttgtaa gacgtccgac aagcatgacc tgattgaaca tgcgattcct cctctccttg 3391681 cggttgtatg tattgtaaat gatgcaacaa gaaaagaaaa acgcttaaaa atggctttca 3391741 gcctctgttt ttatctttcg ttttcatttt tccttcagct aaaaacatct tttgcttttt 3391801 tcctttgaag aaatatgtac tttttaaaaa acggaaaaag atttgctttg tcagccagtt 3391861 ttgcgtattc atgcgcacat aggaagagcc atcccacgca aaccactgaa agctcaattt 3391921 tttttccggc attgacagct tgattttata ctgctccatg ccatcttgtg tttcgtataa 3391981 aaaacttatt cttccttttt tgttcagatg aacctcaaac acttctttac ggcttaacat 3392041 atatgttact tccttttgaa tcaaatgact ttcagaagga acgccgtcaa tataaatttc 3392101 ttttaaacga aattgattca taccacatct ctccgtaatc catagtcagt tacagtataa 3392161 tgaaaaaata gaaattatta aatgtttcgc tcatacaaaa ttctttagcc ccaacattgc 3392221 aggatttttt cctcgaaaac gtttatgtta taatggaagg caagaaaact ttggaagtaa 3392281 tcggggtgag aagaaatgaa aacctttaaa ctggttgacc tgaatgtgga acgagtggac 3392341 aaggaagaac aatcaattga acagtttccc cttattgacg gactgattat aaataaagaa 3392401 gacggtgaaa atcactggct gattgaggcg cttgtacaga aagaacatct gtcttttttt 3392461 gaacagcttc aaaacagcca atctgaagcc aaagtatttg taacgatcac gaaaaaaagc 3392521 aatcgccccg cccagctgac agcagcagtg aaaaatatcg tcaagctgga agaaagcatt 3392581 caggttttac tctacggaca aatggtcaca agaaaacagc agggcactga aaccattctc 3392641 gagtcccttg taaaagaggg ctatacagga acaaaactca ttgaggcatt taagcaaaaa 3392701 ttataaatat gagggggcat gttccccaaa acagactcag aaccgaagag catcacaata 3392761 gacatttaga atagatatgt tctgcatgaa aaaagctgcc gttttgaacg gcagcttttc 3392821 tcttcgtgct ttcactcttg catatttaat ttgtatggcc aaaagaatca accaattccc 3392881 ctttcacaac gaggcgccct tcggttttga ccgccttgtc acatgtgatt aacgtaatct 3392941 cctttttgtt tgtctcctca actacatctg catccatttc cgatatgatg tctttcgatg 3393001 ttacagaata gatataatcc tttttaaaat ccgtgatgac aatttgggca cctgttttta 3393061 tgttttccag aggtccgaac agaagattct tttgcttcaa atgatggccc gccaacggat 3393121 aatttccctc acccattttt tgatcccggc gcattgttgc cgcccctatc aaaagatttt 3393181 cattggttgt gccttttacg atcggaagct ccagatcgac acttttaatt gttatccgcc 3393241 gccttgattg tgaagtaaaa ataagtatat ttcacgtgct ttcgacgttc tccacttgac 3393301 tggaatgctt taatggcgat cccggcatct gtagcttcag gctttccttc agaggaatca 3393361 gaaatctcaa actctatttt ctcagtgttc agcacataac cggctggcgc tttcgtttca 3393421 acaaaagcgt attgtcccgg tgcaaggcct gaagctgtga cttgatgatg ccggatatga 3393481 ctggtttcga agtctgtatg aaaattcgcg aacgattcag catggttgat cttccggttc 3393541 tgatcattac agctgccatt atcggccatg acaaatacaa ggcttttcat gccggagcga 3393601 atgacatttt gcaaaaaccc tatcattact ctgaatttat ggcgcgtatt caaaacctga 3393661 taatgatgaa acatacagca aatcaagcca caagaatgga aatggcgttt ctccagtcgc 3393721 aaatcaagcc tcattttctt tataatgtat taaacacgat tatttctctc actcatttgg 3393781 atattgaaaa ggcccgggag gtaacagagg aatttaccaa ctatttaaga atgagttttg 3393841 actttcaaaa tacatcagcc atcagttcct tcagacatga gctttcgatt atcaattcct 3393901 atctttctat agaaaagacg cgattcagta atcggcttga ggttcttttc gatatagatg 3393961 aagacattga ctttatcctt ccgcctttaa tgattcagcc cttggtggaa aatgccgttc 3394021 ttcacggtgt cagcaagaaa agaggcggag gatggatcaa actgacagct aaaaaacaaa 3394081 gcaaaaatga gtatcacatc aaagtagagg ataacggtcc cgggataact ccggaaaaac 3394141 aaatagatct cttatcaacg gattttgatc gcagcgtcgg attgaaaaat atcaatcagc 3394201 ggctgaaaca tttttgcgga agcgagttga tgatcagcag cactccggat gcaggcacct 3394261 ctgtctcaat gctcattcat ctcgctgaaa caacaggaag ccctaaagaa ctgaaggaca 3394321 cagaacgaac ctaaacgaaa attgagataa aaaaagacgc cgtttctaac ggcatctttt 3394381 ttattccggc gactttgctt gctgcttcag caggtctctg atttctttca gcagctcctc 3394441 ctgcgcatcc accgcttcct ccgcagcctc ttcttctgct tcttttttgc gccttaaccc 3394501 attcaaagtc cgaatgacga taaaaatgga gaacgatata attaagaagt tcacaatcgt 3394561 ctgtataaag ctgccatatt tcactacagc atcgccaaac gtaaacgaca ggcctgaaaa 3394621 gtcaagccct cccagcagca aaccgaccaa aggcataatg atatcattta ctagagatgt 3394681 gacgatcttt ccgaaagcgc cgcctatcac aacaccaatc gcaaggtcta cgatattccc 3394741 ccgcatggca aaggctttaa attcattcca catacaatca cctgcttttc tatatttgta 3394801 aagaaaaaaa gacaaatgtg ccgctggcca tctgcctttt ttcaattatt ctccgagggc 3394861 aaaagtcagt tctacttcgc aaacgacttc gccatcaact gtggcaacgc cttttccgcg 3394921 cccgattgtg ccgcgggcac gaatgatttc aacctcaagg tgaagctggt caccaggctt 3394981 gacttgtttt ttaaagcggc agttatcaat gcctgcaaaa aaagccagtc tgccgcggtt 3395041 ttcttcttta atcaacatcg caacagctcc gacttgagcg agtgcttcta cgattaatac 3395101 gccgggcata accgggtact gaggaaaatg tccgttaaag aactcttcat tagcggttac 3395161 atttttatag ccttttgccc gtttgccctc ttcaacttcc gtaatccgat ccacaagcaa 3395221 aaacggataa cggtgaggaa taatttcttt aatttgctga gtatcaagca ttgtcttgac 3395281 atctccttca tctgcattag tatgtatagc aatcatcaaa gatccaatct gtacatttga 3395341 aaagtatatt atgaattaat ctctttttca accgcgctaa aatgtaacca actgtcaatg 3395401 agagccgtca aaagttatga tatgataatt atagatttta ccaatagcaa agaggtagga 3395461 aaatgatttc gaagtttatt gaaaaaagaa tgctaaacat gttagacgag tggtattccg 3395521 caatgagcaa acgcaaaatg aatcacgttt gcacactgaa agagaaaatt gatcagcacc 3395581 ttccaaagat caaaaagaac acaaaacttt ggatgcgtta tcaattgttt caggcccgcc 3395641 atcagctgct ttttgaaaac cagaacggac tcgattcatt gttcgatggc ctatatggcc 3395701 tggaagacaa aatggatgat gaattgaaat attatctgta ttttttctct gggttatatg 3395761 agatggtaaa aacagctccg aaacatgcag tacatcattt taaaaaagct gaacagtacc 3395821 tggccgccat tcacaatacg tttgaagccg ctgatttata ttatcaaacc gccggcgcct 3395881 attacttgat gaaatcaccg ccgctttccg tccaatacgt caaaaaagca ttacacatct 3395941 atttgcacca attcggctat atcaaaaagg taatcacctg taaacttttg ctcgccgtga 3396001 attatattga tcaagaacgc tatgaaaaag ctgaacagct tttcaaagaa atcattaaga 3396061 aaacccagca actacatgac gaaaacctgc tatgccacgc ttattataac cttggctttt 3396121 taaaagcgac cgagaaaaaa gaccaggaag cgcttcttta ctttagaaaa gtattaaaga 3396181 atcaagaatt tgaaatgaat tcaccagtct catatcttca ttgtgtgtac gagtctgtca 3396241 gagcgctttt taaaacaggg aacatcacag aagctaaagc cgtccttcaa aaaggaaaag 3396301 aattatctga aaaggtagac attcaaacca tttatttaaa attaaaaacg cttgaagccc 3396361 tctacacatc agccgaagac ccttatgagc agctgctcga atatgtgctt gaattagaaa 3396421 aaatcgaggc gtgggtggat ttagaagtgc tgttagaaga tattacggaa tactacaaaa 3396481 aaaaggacga tttcgaaaaa gccgcttttt ttatcatgcg cggctgattg aaaaacgccc 3396541 attttcttat tatctgactg aattgattaa accgagcatt tgatctccca ttgtgatcgt 3396601 tctgctgttc agctgatatg aacgctggga cgtgatcaaa tctgtcattt gttctgaaat 3396661 atcgacattg gacatctcaa gtgagccctg ctgcatgccg atgttttgtc tattagcgcc 3396721 gttcagctct tcaaaagctg ccgcattatc aatagagaaa aggttattcc cttcggattt 3396781 cagctcttga gggttattca cttggacaac gccaagatta aaccgctgaa ccgcgtttcc 3396841 gtcagatgcg gttaaggtgc cgttcttatt aatggtgata ttcttcattg agctgtcgat 3396901 gttcactgta ttgccgttct catcaagtac gggataccca tttccagtga cgagctgcag 3396961 ctggttggca ttcgcagcgg acggcgttac atacagcgcc ccgtccctcg tatactggcg 3397021 gtttccattt acatttacct gaagatactg gtatggagac gtaaatgcga tatccagatc 3397081 gcgatcggtc ttctgaatgc ttccttgatc agagactagg cgtgaactca tcatcgctcc 3397141 gacgccaagg cgcaagccgg gcggcgtttt tcgggctttt gccacttcct cgtttttttc 3397201 atcaacctga tcgaattgct gtctgacaag ctcagaaaaa ttcgtatctt ttgccttata 3397261 gccggttgtg ttgctgtttg aaaggttgct gctgattgtg tcaatctgct gctgcagctg 3397321 gtttaaggtt gttgatgccg ttagcattga cctgagcata gttgatgtcc cccgtttttt 3397381 tcttccgttt tcttaaattt ttccaatttc atttgctgct ttatccatac ttttatcgta 3397441 agcctgaata accttctgat tcgcctcaaa cgatctgtac gcttcagtca tttctgtata 3397501 ggcgcttgtc acatccacgt ttgaaagctc tgagacgcct tgttttaatg aataggctac 3397561 ctgattattt ccggctgcgc ttggcagatc attaccgtcc gccgtgctgt acaaatcatt 3397621 tccgtcccgt ttgagattgc ggacatcttc cgccattctg acatcaatct ggccggctgt 3397681 gcgtccgttc gttgtcacag taccgttttc agacacagtg aaattctcat tatcaacagt 3397741 gattggctgg cgatccgtcg ataaaatagg gcgtccgttg atcgtcagct gattgttctc 3397801 atttagtgaa aatgtgctgc tttttgaata acggattcca tccgctgttt gaaccggata 3397861 aaaaagagca gctttttcat tggtttccgc actcatcgga acttgatttt cgatcaatgc 3397921 aatgtctgta ggctggtctg tggacttcag gcttccctgt gtaaagagag gcttgagctc 3397981 ctgcatatat actccggtat tcacggaacc gatttccgtc cttgatgtcc cggccggaga 3398041 ttttgattct attctgctga gcagcatctc agggaacgcg cgcatagagc cttgatcagc 3398101 tttatatcct gatgtatttg cgttagcaat attatttgaa agcatttccg ttcttcgctg 3398161 ctgggcaatc attgcggatg ttgctgtata taatcctttt aacaaatttc ccacctctaa 3398221 aaatggcatt ttttccagtt gtcatatagg aacgttcgtt ctataataaa aactcagtat 3398281 tttatcctat tatcgtcatt taacatcttt tcgtgaaggc tttttcataa aaaaacctca 3398341 ttctttttca gaatgaggtt tgtgaaatca gcttagtttg cgtttaggaa gcttgtccat 3398401 attatcaagc atgacacctg tgccgatggc tacgcaatcc ataggatttt cagcaacgag 3398461 gaccggtacc ttcagctctt cagcaagcag ctggtcaagg ccgtttaaga gcgcgcctcc 3398521 gccggtaata ataacgccgc ggtcaataat atcagcagaa agttcaggcg gtgttctttc 3398581 gagcacttgt tttgcagcct gaacaataac agcgacagat tcacgaaggg cttcttcaac 3398641 ttctttactg tttactgtaa ttgttcttgg aagaccggaa accatgtccc gtccgcgaat 3398701 ggaaatttcc tcgtgacgtg cgtctgggaa aacagttgcg actttaatct taatatcctc 3398761 cgcagtacgt tcgccgatca gcagcttgta ctcgcgtttg atataattta agatttccat 3398821 gtcaaacttg tccccagcca ttttaataga agaggaggtg acaatatcgc ccattgaaat 3398881 aaccgcgata tccgtcgtcc cgcctccgat gtctacaacc atgttaccgc ttggctggaa 3398941 tatttccata cccgcgccga tagcggcaac tttaggttct tcttcaaggt acacatgttt 3399001 cccgccgctt ttttctgcag cttctttaat tgctttttgc tcaacggatg taatattcgt 3399061 cgggcagcaa atgagcatgc gcggctttga gaacaggcct tttacattca gcttgttaat 3399121 aaaatgtttc agcattgctt ctgttacttc aaagtcagca ataactccgt ctttcagcgg 3399181 gcgaatcgca acaatattcc caggtgtacg tccaaccatt cgtcttgcct cttcgccaac 3399241 cgccagcact ttgccgctgt ttttatcaag tgcaacaacg gaaggttcat tcagaacaat 3399301 tcctttacct ttaacatgga tcagtacatt tgcagtaccg aggtcaatac caatatccct 3399361 tgcaaacatc tatttatatc ctccttgaaa atctgtttca cagtaaatat ccacattgtg 3399421 ccctaattat atatattatc ataaaatata gaaaaaaagt tggaagcaca ataagttctt 3399481 tacaaatttt tgcggatgtt ttatgaacga tttcaagaag gcaatgccag gtgattacga 3399541 ttgctgaaca ggctctcctt cgagaatttc atctttttta tatttgagct ttgtcgcttc 3399601 tcctcctctt aaatgcctga tggatttatg ataatcgagt atttctttca cttcgtttgc 3399661 caagtcgggg ttaatttcag gcagacgctc tgttaaatcc ttgtgtactg tacttttgga 3399721 aacaccaaat tccttcgcaa tgacacgaac ggttttcttt gtctccacga tgtacttccc 3399781 tatcttgatt gttcgctctt tgatgtaatc gtgcacacca ctcgacctcc ctaaaatgga 3399841 tgtgagaagt gtgaaatgag atccgtattc tgtaaagagt cgttcattat gccgcttctt 3399901 cgttgtatgg ttttaaaagt aagtttgtga aatatgccca cgatccctca cctcaaacac 3399961 tctctttgtt aggtttgtaa cagtgtatta gcattctttt gggaatatgc taaaaactca 3400021 ataaggacaa ggggtgaaac gaactttttc agattcagca aactatttcg cgtcactaaa 3400081 ttttcatctt tacaactatt gatcgctcct gtaaaatgaa ataagcaatt agttacttag 3400141 gtaagttttt tagaaggaga ccgacatgtc ctacgtcaac agacacctca ttcatcaaat 3400201 caaccaaagc gcccgcctga ttgccaagaa agccaatgaa cagctagagc cattcggcct 3400261 ttattcatct caatggtcag ttttatattg tttgcgtacg atcggaccaa tgactcaaaa 3400321 agagatttgg tcctatttaa atgtggaagc gccgactgtg actcggacga tcaaacgcct 3400381 ggaggagaac ggctgggttc agagacggca aggtgaagac aaacgggaaa aacttgttgt 3400441 cctcacaaaa gaagccgaga aaaaatacga agaaatcaat gtgaaaatgt tgaaattcga 3400501 ggaagagctg cttgcagatt tccgggatga agataaagaa gctttttctc atttattccg 3400561 catgttttta caacaatgaa aataaggaag tgacatacat ttgaaaaaag cggatgcgat 3400621 atggaccaag gattttatta tggtcctgct tgtcaattta tttgtgtttg tgttctttta 3400681 tacattttta actgtattgc cgatctatac actgcaagag cttggcggca cagaatcaca 3400741 aggcgggctt ttaatcagcc tgttccttct gtctgcgatc attacacggc ctttctccgg 3400801 agccatcgtt gagcgtttcg ggaagaaaag aatggcgatt gtatcaatgg cgctcttcgc 3400861 cctatcatct tttctgtata tgccgattca taacttttcc ctgctgctcg gattgcggtt 3400921 cttccaaggg atttggttca gcattttaac gactgttaca ggtgcaattg ccgctgatat 3400981 tattccagcc aaacggcgcg gtgaagggct tggatacttt gccatgtcta tgaacctcgc 3401041 tatggcgatc gggcctttcc ttggcctgaa tttgatgaga gtggtaagct ttcctgtatt 3401101 ctttacagcc tttgcgctgt ttatggttgc gggcttactt gtttcgttct tgataaaagt 3401161 gccgcaaagt aaggacagcg gcacgactgt attccgtttt gcgttctcgg atatgtttga 3401221 aaagggcgca ctcaaaattg cgacggtcgg tttgtttatt tctttctgtt attcaacagt 3401281 cacatcatat ctgtctgtat tcgccaaatc agttgacctt tcggatatca gcggatattt 3401341 ctttgtttgt tttgcggtga caatgatgat tgcacgcccg ttcacaggga aattgttcga 3401401 caaagtcgga ccgggcattg tcatttatcc atcaatcctg attttctctg tcggactctg 3401461 catgctgtcc ttcacacata gcggcttaat gcttctgctt tcaggggcgg ttatcggtct 3401521 tggctacgga tcaatcgttc cttgcatgca aacattggcg attcagaaat ctccggctca 3401581 ccgctccggt tttgcgacgg caacgttctt taccttcttt gacagcggaa ttgctgtagg 3401641 atcgtatgta ttcggattgt ttgtagcatc tgccggcttc tctgccattt atttaacagc 3401701 ggggctgttc gttttaattg ctctgcttct ctacacgtgg agccagaaaa aacctgcaga 3401761 ggctgaagga aaagtgtcta ttgcagaata acttgtcaga ctgccgggaa atcccggcag 3401821 tcttttttcc attaaaacac ggcgccctct cggttgaacg agagaacgcc gcttatagca 3401881 attattcaat gacaggccgc gcaggtgaat caggatctaa cgaaaaatca taggacgctt 3401941 catcacgaaa catcggatcg gcatatatgg attgttgatc gttttttgtt gcttttcgat 3402001 acgaagaaaa tgaatcatat tctttctttt tccacatcca tatgccgtct tgatccgctt 3402061 ccttgtggta cacgttatga ttgaccgtat taccttcgtt ttctgtaaag tcgtttccga 3402121 taaataatct ggaatcaccg gccgtcaata tattcttttc aattgtgttg tttttcgtat 3402181 cgtactgcag cagcagctgt ccgccgtaca gtccctttgt gtcattccgg tacataatat 3402241 tgcgggcaat cagagaattg ctggtgccgc cccgcttttt gtcatatcct ccgattgaaa 3402301 taccggtgta cgcattgttg tacactttgt tgtctgtgat ctgaatggca tttgcatact 3402361 ttcctttgtg ttcagacgtt gcttcaatcc caatatcgtt atcgtaaact gtgttgttct 3402421 taatttcgat atcgtgtcct ccatcgacat aaatcccgcc cgctgagtat tcatctccat 3402481 aagcaggatt gccgtaagtc gagttttgat aaactgtatt gttttctacg actccgtttc 3402541 gcacgtaatc gtttttatcc gcggttccct cataaccaat tagatcaatc ccgatgttat 3402601 tattgttgcg gaccacattg cctgcaactg tgaagccgtc gatattaccg ttcagcacaa 3402661 ctgcttcact cgctccaagc gtcagtttct caactgtatt gtcctcgatt cggatgtctt 3402721 tcatgctgcc agtcccataa actgcgattc cgtgagcatt tccttcatcc gctgttgtct 3402781 taatcccccg gatgtgatta tccttaatgg cgatatgact gctggaccct gatacataaa 3402841 tccctatagc agttgcttcc tcagatgaaa cagaaagatc ttgaattgtt aaaccgctga 3402901 tggcaatgtc atgtttatcg tgaatacgaa taagcggtgt ttcatattca gcgttcgcaa 3402961 cggattcacc gctaatcacg acgttttcat tttcatagtt tcggaatgtg ataggctttc 3403021 cgtccgtacc gctgtgcttt acatcaaggg tctcatgata cgtgccctcc cgaatcatga 3403081 cagttgtgcc ggcagcagcc ttctcagatg cgtgtgccaa tgtacgaaac ggcttttctt 3403141 ttgttccttc attttgatca ctgccatttg gcgaaacata cagataatcc ccagatcctt 3403201 cctcattcgc ttttgtctta tcataaacga aagcgaggat gacagacgtt aaaacacccg 3403261 ccaaaagaat aaaataccat tttctcattt tcgattccca tttcgtttta gaatagattt 3403321 ctaaaaccat tataaatgtt ctatttatgg aaaaccattt caaaaatatg aaaatatacc 3403381 gtctaaatag atcttattca gcctggcgga cctgcgcatg ttcaactgtt tcaattgcca 3403441 atgatgcagg cgggtgaaca cgcatcagaa caatgtagaa aagaaaggaa atcagcacac 3403501 ctacaaacca agaaatatcg tataagctct tcaatacagg aacatacatg ccaatcagcg 3403561 aaatcagcgc tcctaacatt gtggctgcaa acgcacggta attgtagccc ttccaataca 3403621 cataccgtcc tgtttcggaa tacaggtcat ctaccgagag ctcacgtttg cgaatgataa 3403681 aatagtcggc catcatcacg cctgccaccg gtccaagcat gccgcctatt aagccaagaa 3403741 acgcatacac gcttgtcgcg ctctccatca gcttccacgg aaccgtaaat aaagcgagca 3403801 acgctgtgat aaagctgcca cgtttgaaat tgatatattt cggcagggca ttcgctatat 3403861 cataagcggg tgatacgata ttcgccgcga catttacaga gatcgtggcg atgcagagtg 3403921 tgatcacgga caagacgatg acataagggt tatcaaaccg cgccaaaata tcgacaacat 3403981 cccaaatcgg ctctccgaac gcgacctgcg agccggaggt caccgtaata cttgcgaatg 3404041 cgaacagcgc aaacgttccc ggcaaaccgt aaaattgtcc tttgatttgc tctttttgtg 3404101 tttcagcaaa ccgtgtaaaa tcaggtatat ttaagatcaa tgtcgcccag atgccgatga 3404161 tgccagtaac tccggcagca aacggccaga atgtttctga aaacgtatga aactttcctg 3404221 gttgagagta tatcgggccc aatcctccag caatatcaac ggcccaccat accatgccgc 3404281 caaataccag atacactaaa ggccctgccc acacctcaaa acgtttaatc gactccatgc 3404341 cgtgatgcaa tacgagtaaa tgaatggccc aaaagaatac aaaggaaagc aaaccggaca 3404401 agtgaatgcc gagaatgttc cactcgccgc caatttctcc ccaacctggc cacatattca 3404461 aaagcaaaat gttcagtgcc gtgctacccg caaaggtctg gatgccaagc cacatgatag 3404521 ctgtaaacgc ccttagaagc gcggggatat tcgcgccgta tatcccgtaa gaagcccgaa 3404581 tgatcactgg aaacggcagc ccgtattttg tccccgcatg gccgtttaag gcaagagcgc 3404641 caaataggat aagtgatgcc gtaataatga tcgccagcac ctgccaaggc gaaaggccga 3404701 tcgcaattaa tcctcccacg gtcgcgtagg tcggtatgtt atgtatacat cccatccaaa 3404761 tggaggcaaa gttcattgct ttccacgtcc gtttttcctg tcccaaaggc accagatctt 3404821 cattgctcag cctgttggat tgctgctgac tctcttttaa tttcatagcc ggctcccctt 3404881 tccatattgt ctatatgtcg tcacacgtta tgttttttga cattagatgt cacttaatat 3404941 aactgaagag tcagacaata acactggcta tgatatacaa ttttcccgtt tgtatttgaa 3405001 cagcttaaac aagaaaaaga gacagacctc agagcccgtc tctttcttaa gatgcagttt 3405061 tcattaatgc agcaaatctc acagccatta acaggcttgc tccgcccgct ataatcataa 3405121 tgattcccat catatcaaaa tgggctgccg tgatttcttt accaaaaaga atgccaagga 3405181 tcaccgaaga caaaatcgat cctaggtaac ggcaggtttg aaacaggcct gaagtcgttc 3405241 ctaccatgtt ggaaggactc gtttccagca tcgctgcctg aagcgcgaca ttgcccagtc 3405301 cgtagcctat acccaagagc gacagaatga ggcctttacc gatggtctgg acattgataa 3405361 aaaagatggt taagagcacg gctccagccg tcatcaaaag cgctcccgca aagatcggct 3405421 tgacgacacc agatcggtcg atccatttgc cggttagagg tgacacaacg atgctcattc 3405481 cagacataaa cagcataaac aggccgctcg tttgaacaga aagatgcatt tcatcctgaa 3405541 agtaacttgg caaaccaaaa aataaacaat agaagaaaac attcaataaa ataaactgaa 3405601 catacacggc tgacaggttt cgctgtgttt taaacagacg gacatcaata aacggcttat 3405661 ccgttttcag ctcgcgccag acaaacgcac agagcagaag caagccaagc acaccttcaa 3405721 ccgcatgcgg cgacgtgctg aacgacagca aaaaggatag aaggaaaatg attcccccgg 3405781 caaataaaac aattccaaga atatcgagct gccgaataat ggttttgatt cctgcccctt 3405841 ttttctgatc tttcgggaac atatacaggc ccaataagaa gctgaggata ataaacggca 3405901 aattaacgat aaagatcgcc ggccagcctc cccatacaat caaaaacccg ccggctgtcg 3405961 gccccagcgc cgtcatggcg gacgcaaaaa tagagagtac agccaaggct gaagcttggc 3406021 gctcatgaat atgattccga atcaagccga cacctgacgg ataaatcgca ctgctcccca 3406081 ccgattgaaa cagccgcatg accaataatg tcataaacgt cggcgcaaac ggcgccccga 3406141 tggcagaaac cgcaacaaga ataagcccga ataaaaacaa gcgtttccgc ccaatcaaat 3406201 caccgagctt tcccgttacg ggctgcgcta cggcactcgc caagtaaaac gaggaaatca 3406261 gccaggaaac cgttgtaaac gagaggtgaa actcatgctg gatgctatgg agcgcaagag 3406321 agatcataga cgagttcagc ggattcagca ttgttcccga agccacagct gttaaaaaaa 3406381 cagctcggct ttttttcgat aacatcattt cacttgttcc agaaactctt ccgttgtccg 3406441 cgatttaccg attctcggga aaataaagcg cagtgtggct tcatgctctt catcgctaaa 3406501 tgtggacatg gcatctgtaa taaaaatctg ctgatagcca agctgaaatg cctcccgtgc 3406561 tgtgctttcc accccgatat tcgttgcgat gccgcacaat acaatcgtat caatgccgcg 3406621 acgtctcagc tgcaagtcta aatctgtgcc aaaaaaagca ccccattgcc gttttgtcac 3406681 agtataatcg ccatcctgca caccgatttc cggaacaaat tcggcccagt ccgccggcat 3406741 ttcccctgaa cctccctgcg caggctcatc cgtttgcggc ttcagggcgt ccgctccatc 3406801 atgaaaggct acatttacaa agctgatgaa cccgttatgt ttccgaaatt catctacgag 3406861 ctttttcgcg ttcgggacaa cctggccgct ttgatcaatc ggcacaattc ccttttgtaa 3406921 atcaatgata accaatgctg ttttttgaaa atcaatgttg agtgtattca tcatacgtct 3406981 cctcctgata ctgttagtgt ttctcacatt gcatatttta ctcttcacac tgcctaagtt 3407041 cttttatgat gcttgtgaaa ttctcagaag gagcgttttc tcatgatttt tcttttatgt 3407101 agtagtaaca ggttgtgcat acgaacaaac cggcaagcac tgtaatcata aagggcgtca 3407161 tcgcttcatc acctgcctgc tgtctatcgg ttcctgcctg aaaatgccca tgaatttgcg 3407221 gcggtccatc caaagcagga taagacacat aaccattaat atcgtgctaa gatcctgcac 3407281 gccaatatca aaacaatagt taatcaagac gatgttcaca ataatgggca taaaaataac 3407341 cgcccctaat gcagccgttc gcggaatcag taataaaaca gctgccagga tttcaccaaa 3407401 acctataaac agttcataga catgagaata accgaaaaat gtccacgcga tcgtaaaccc 3407461 cttcccggca gccgcctcga tttcaggcgt cacctcgcca aactggccaa ttaccacttt 3407521 cgccagaccg tacacgaaaa aattaaaggc taaaaacaat cggaacgtcg cgggaatcga 3407581 cttgcgtacc gctttcctca gcctgccgcc tttattcatc atacatcccc ctcagtgtat 3407641 tatttgatgt agtacactta atacagtata gagtattcta attaatgtca attccctttt 3407701 cagctcatat gaatagtttc ttttatagat acaaagtctt atatcgcaaa aaatgccatt 3407761 ctccttcctt tccatccctc gataacattt ctcaaaaacc atgtcaggaa atcttacatg 3407821 aaaatgtttt atcattcttt tttctctata atgaagaaat ataataattg ctttttattc 3407881 tgaaagatac ggaggaatga gacatgcaaa tgggcgatac agtttttatg ttcttttgcg 3407941 ctttactcgt gtggctgatg accccgggat tagcgttatt ttatggagga atggtaaaga 3408001 gcaaaaatgt gctgagcact gccatgcaca gtttctcttc cattgccatc gtttccatcg 3408061 tttgggtgct gttcggatat acacttgcct tcgcaccagg caattcaatc atcggcgggc 3408121 tggagtgggc aggcctcaaa ggggtcggat ttgatccggg agattacagc gataccatcc 3408181 cccactcgtt atttatgatg ttccaaatga cgttcgccgt tctgactaca gcgattattt 3408241 ccggggcttt cgcagagcgg atgcgattcg gcgcttttct tttattctcg gttttatggg 3408301 cctctttggt ttacacaccc gtagcgcact gggtatgggg cggcggctgg atcggccagc 3408361 ttggagcgct cgatttcgct ggcggcaatg ttgttcatat ttcctccggg gtggcaggac 3408421 ttgttcttgc cattgtgctc ggcaaacgga aagacggtac agcgtcttct ccgcataacc 3408481 tcatttacac cttcttagga ggagctttga tttggttcgg ctggttcggc tttaacgtcg 3408541 gcagcgcatt gaccttagat ggtgtggcca tgtacgcgtt catcaacaca aacaccgcgg 3408601 ctgcagccgg gatcgccggc tggatcttag tagaatggat cattaacaaa aaaccgacaa 3408661 tgctcggagc ggtatctggg gcaatcgccg ggcttgtcgc cattacgccg gctgccggat 3408721 ttgtcacacc gttcgcttcc attattatcg gcatcatcgg cggagctgtt tgtttctggg 3408781 gagtattctc gcttaaaaag aaattcggat acgacgacgc gcttgacgcc tttggcctgc 3408841 acgggatcgg cggcacatgg ggcggaatcg caacaggatt attcgcaaca acctctgtta 3408901 actcagcggg cgcagatggg ttattttacg gtgatgcaag cttaatctgg aaacaaatcg 3408961 tcgccatcgc cgccacttat gtttttgtat ttattgtcac tttcgttatt attaaaattg 3409021 taagcctctt ccttcccctt cgcgcaactg aagaagaaga gtcacttggg cttgacttaa 3409081 cgatgcacgg ggaaaaagca tatcaagatt ctatgtgagg agtgacgcta tgagcggtca 3409141 aatgttcaag gtagaaattg taacgcgtcc ggcaaatttt gaaaagctga agcaggaact 3409201 cggaaaaatc ggagtgacct ctctgacttt ctccaatgta cacggctgcg gccttcaaaa 3409261 agcacatacg gagctctatc gaggggtaaa aatagaaagc aatgtatacg agcgtttaaa 3409321 aatagaaatt gtggtcagca aggttcctgt tgatcaagtg acagagaccg ctaaaagggt 3409381 gctgaaaacg ggatcaccag gtgacggtaa aatatttgtc tatgaaatca gcaatacgat 3409441 caacatccgc acaggcgaag aaggacctga agcactttaa tatcggtacg agattcggac 3409501 actccggatc tctttttttg tgcacagaat ccccccagaa accgcgattc ctcttcgaat 3409561 tctcttcaag cgccgttatt tcagacaatc tctattttta tttgaaactt ttcatgagta 3409621 agattagtct actaaatata aaaatgtaaa aggtgattat ttgaactacg aaatttttaa 3409681 agcaatccat ggactatctc atcacaattc agttctcgat tccattatgg tcttcatcac 3409741 ggaatatgcc attgtcgcct atgcccttat cctattggca atctggctgt ttgggaacac 3409801 acaaagcaga aaacatgtgc tatacgcagg catcacagga attgcaggcc ttgtgatcaa 3409861 ctatttgatt acgcttgttt atttcgaacc gcgcccgttc gttgcgcata cagtgcatac 3409921 actgattccg catgctgcgg atgcttcatt tccaagtgac catacgacag gtgcattagc 3409981 gatttctatt gcgatgcttt tcagaaaccg caaaatcggc tggccgcttg tcatttttgg 3410041 gcttttgaca ggcttttcga gaatttgggt gggacatcac tatccggtag atgtattggg 3410101 cagcctcgtt gtcgccatca ttatcgggtt ccttttcttt agattttcag atctgcttcg 3410161 cccgttcgtc gatttggtcg tgaggatcta cgaagccatt atcaataaac tgacgaaaaa 3410221 accaaccgat caaaatttct aagaaagaca aaagccggcg tctgaaatca agacagccgg 3410281 ctttaatatt tctcatacat ctcttgtttt cttcgcttcg ccaacacata taaaccataa 3410341 aacaacccaa ttccaacagc atcgatgagc acatcccgga tacaaccatt cctgctgaag 3410401 aagagctgaa gaacttctgt gaaaaaagca aacgcaaatg agccggctgc agctgatctt 3410461 atgctgcccc gctgtttcca cagcaaatat gtcagcacaa agaaggaaaa cgcgtgtccg 3410521 attttttgaa taaacgcttc aggtacagta agctcagtaa aatccataac taaaaattga 3410581 gacagatcag ggtgcggctg aaaatgaaaa gccaccgttt gcgatacgac catgccgctg 3410641 aagctttccg tacagacaga aagcaggata aaaaagatcc agcctgcgag caataggcgg 3410701 ttcatgacat aacctccttt ataacgtacg tgcctacatg taactacata gacggtaaaa 3410761 caaagcaaaa agtaacagaa aaaaacgccc atcacaagga tagacgtttt cttcattaag 3410821 actgttcagt gtcttctgtt gtgctgcttt ctttagaacc agatttgtca gttgaatcat 3410881 cctttttctc accggatttt tcttctgttc ctttttcagt tgatccgtcc tttttctcgg 3410941 aagattgctg aatggattct tctgtttctt gggtggcagc tttttcaata gaagaaactg 3411001 gtttgtccat aaagtttaac ggattcattg caaccccatc tttacggatt tcaaagtgca 3411061 cgtggtttcc gctgtcttca ctgtaaaggt tcttgccaga ttttccgatc acttgatttt 3411121 gttttacttt gtcaccttgc tctacgctta cttcggaaag agattgatac acagtcgata 3411181 aaccgtcggc atgttctact tccacaacat atcccagcac tggatctttt tcagctttaa 3411241 caaccgtacc gctcagagaa gcagagacat cgaaatcttt tccgtctttc tcagctaagt 3411301 caattccttt gcttaggctg tacgtgttat tataggtaac gagtgctgct tctttctctt 3411361 cttttgcggc atcggtttca tagaactttt tcacaacaga aacgttttca gaatcaacaa 3411421 ccggcattgc gacattttcc attgactttc ctacttcaac tgcatcgtcg ttgttgtcat 3411481 atgcggagtt tccgccgtta tcagccaact gatcctttac ctcatcattt gatactgatt 3411541 gataccaaag gacagctgtt aaaatgacgg ccgcactgac taagtaaatt gcagggaaca 3411601 cccagcgttt acgaaaaaac tgctgaagtt ttttgacttg agaagttttc ttttcttcct 3411661 ctctcattgt ttcatcacct cagcaacatt ctgaacactt ttctgaaaat atatacaacc 3411721 tatccaaaaa aactttttta gatgtagttt gcacagactg aacgaaaata tgtatttttt 3411781 tgagaggagt gccaaaaacg tatgaacatg acattgcgtc ttgctgaaca tagagacttg 3411841 gaggctgttg tggcgattta taattcaacg attgcttctc gaatggtaac agccgatacc 3411901 gaaccggtaa ctcctgaaga ccggatggaa tggttttcgg gacatacaga gtcacgtccg 3411961 ctctatgtgg ccgaggatga aaacggaaac gtcgctgcct ggatcagctt tgaaacattt 3412021 tatggaaggc cagcctataa taaaacagcg gaagtcagca tatacattga cgaagcatgc 3412081 cgcggcaaag gtgttggatc atatttgctt caagaagcgc tccgcattgc cccgaatctt 3412141 ggcatccgct cacttatggc cttcattttc gggcataata aaccaagcct gaagctgttt 3412201 gaaaagcacg ggtttgcaga atggggacta ttccccggca tcgccgaaat ggacgggaaa 3412261 agatacgatt taaaaatttt agggagagag ctttcatgat tagtctggat aaagatgaaa 3412321 acgaaattga acatcataat gaagaaaata gccttgttga acaggagact gcacctgttg 3412381 gacaggagag ccgccagctg agcgcctccg ctgtcaagtc gctatccgac attgccaagt 3412441 ggggcaaaat ttctggcatc ttgttaatca ttatgggatc gcttgtcact ctgtctgttt 3412501 tgatgacagt gattggcgcc atcccgggcg tactgctcat tatttcaggc gtatttttga 3412561 tgcgctcagc aaaagcagcc gcggaagccg aaggaaatct aaccggcagc gctggcgaaa 3412621 gcatgcttga aaattacggg acatttataa aaatgcagct gttttatgca gcatccagta 3412681 tcgttactgt cctgatcggg atcattgtag ccattttcgt gctggtggta atcggcattg 3412741 ctgcttttga gaacacgcct tcgtatgatg atccggattc ttattattat gaggatgatc 3412801 cggtgtttga ataatgatga gacaggacag ggcatgagtt ccatataaac ggaaccatgc 3412861 ctattttatt tgactattca aagcaggccg gcgtaaacac caaatcctga agcaagcata 3412921 caatagacat ctctagtaga ggaaatcaac aaagcaacgc tgttacccag aaatgaatat 3412981 caaaaaaacg gatgaagtcg gaatcaatcc gaaaccgcac tttttatttc gggtgtctgc 3413041 atgcaaaaaa acacacccgg atcgtctgga aaatctcaac aatccgggtg cagatcttct 3413101 ttaatacatt tttttgcgtc tgtcttcctc agtcaaaaat tcaacaaaac tccgcatcgc 3413161 aaaaggctct tcctttattt gtcgtgcgta ggagcttttc cgctcttctg aaaggatttc 3413221 gctctttttg atcctgttca gcatatagat gtgaaccgtt ttttggattt gtttatgctg 3413281 atagcctgcc tctttaaaaa atgcgagccc gagcgccgcc aaaagggcga atatgcctgc 3413341 gctgatcagg gactccctgt cagctgaagc atgaaataga aaagcagcta aattaaagag 3413401 agagaatgca gcaagcggaa tagcaagaaa acggtaaatg acggtttttt tcatgaaagg 3413461 ctgtacggcc ttttgaattt tttgcatttc tgttttgatg aaccccggca tttgttcgac 3413521 tctgtaaaag ttcatataat cctccccctt tatttgatgt ttcaagcttc acgaacgtta 3413581 tcatatgtgt ttattttaac gcaggtgcaa gctggtttta aagaaatctg cccgtatttt 3413641 tcacgaagaa tctggatcgc cgctctttat tcttttaaaa tgtgagtgtt ataatttgta 3413701 atgggaatca gatcactgtt attcatggaa tactaatggc aatcttcttg ataaatatga 3413761 atgagcgggg ttacaaagtg agtatttctt ccatcctttt atcacttttt ttcattttaa 3413821 atattctttt ggccatcatt gtcatcttca aagaacggcg cgatgccagt gcatcttggg 3413881 cgtggctgct tgttcttttc tttattcccg ttttaggctt tattttatac ttattattcg 3413941 gccataatct cagacgcaag catttgtttc aatgggaaga ccggaaaaag attggaattg 3414001 aaaggctgct gaagcatcag cttgaagatt tagaaaccaa gcaatttcag tttaacaacc 3414061 gggcaacctt tgataacaaa gatttaattt atatgctgat tatgaataac catgctgtgt 3414121 ttacagagga taattcagtt gacgtcatta cagatggacg ggataaattt cagcggctgc 3414181 tgagtgacat ttcaaaggct aaggatcata tccatttaca gtattatatt tataaaggcg 3414241 atgaattagg caaaaaattg cgggacgctc tcatccaaaa ggcgaaagaa ggtgttcagg 3414301 tcagagtgct ttatgatgaa ctcgggtcca gaacgctgag aaaaaagttt tttaaagagc 3414361 ttcgcgaggc tggcgggcat gtggaggtct ttttcccgtc aaagctcagg ccgattaacc 3414421 tgcggctgaa ttaccggaac catcgaaagc ttgtgatcat agacggtatg accggttatg 3414481 tcggaggctt taacgtcgga gatgagtatc tagggcttaa tccgaaattc ggttattggc 3414541 gggatacgca tatccggctg caaggaacgg ccgtgcacgc catccaaaca cgattcatcc 3414601 ttgactggaa ccaagcttct catcaccata cgctgacata tattccaaat cactttcctg 3414661 attacggccc aaaaggcaac gtcgggatgc agattgtcac aagcggccct gattcggaat 3414721 gggaacaaat taaaaatggc tacatcaaaa tgatttcgaa cgccaagcgt tccattttga 3414781 tacaaacacc ttattttatc ccagatgcaa gcctgctgga tgctttaagg atcgcttgcc 3414841 tttcgggcat tgacgttaac attatgattc cgaacaagcc cgatcacgcc tttgtatact 3414901 gggcgacact ttcgtatatc ggcgatctgc tgaaagccgg agccactgtc tatatttacg 3414961 ataacggctt tattcacgcg aaaaccatcg tggtggatga cgaaatcgct tcagtcggca 3415021 cagcgaacat tgatgtccga agcttcaggc tgaattttga ggttaatgca tttatttacg 3415081 atatcaccat tgctaaaaaa ctggtttcaa cttttaaaga agatttgcta gtatccagaa 3415141 aattcaccta tgaggagtat ctgcagcgcc cgttgtggat tcgaataaaa gaatccgtct 3415201 cgcggctgtt gtcgccgatc ttataagatg cgtaaacccc cggcctttac ggccgggggt 3415261 tttcctgatg gtcacagtaa atgatgattg cctcccgcaa aaaagcggca agaccttctc 3415321 catattgatt gattgaatcg gtaaatcgct cgtcagtgat atacacttcc ccgagtcctc 3415381 tgaaaatgtc gagtgtgcaa tcgtaatgat attggcaaat atgatcgcga aatgccccca 3415441 cagcggcctg aatctctgca tcatcgggcc catgcttcat tcgcgccgca attcgtctgt 3415501 aaatcgaatc aaattcagcc atgatcgtgc gccaatcatc tgccgagtat gcagatgtcc 3415561 ttttctctgt ttcttctgcg atttcctttc catacagctt tctgacttca tcagcgtatg 3415621 tctgctggtg ctcttcaatg tctttcatgc ttaatccggc aaataaatcc ctcttattca 3415681 tcgtttcccc tccatcaacg gacaaaagcg tcctgtcaat tgtttgaatc atctcatcca 3415741 ttctttgttt tttcttcatc aatatctcct tttgcgactg aagtgccgct ttccggtcaa 3415801 aattcggatg atccagcatc tctttaatct catccagacg aaacccgatt tccttgaaaa 3415861 ataaaatctg ttgcagtctt tccaggtctg cgtcactgta caaacgatac ccagcatcag 3415921 taagcgctga aggattcaga agctcaatat tgtcatagtg atgaagcgtc cgaatgctaa 3415981 cgcctgatat ctccgccact tgtttaactt gatatttcat acataacacc tcctcttttt 3416041 tatcgtaaac aatcacgcaa cgttagggtc aatccccaaa atgttatttt ctatatacaa 3416101 aacttctcac aaatagtgta taaaagaaaa gtgagtattt ttttgtaaag gggagccagt 3416161 atacatgaat cctgaaacaa tgaacaaaac cctcatcagc atttcgaaat ggggaaaagc 3416221 tacaggcatt ttatttatta ttatgggcgc aattaccgcg ctttcaggcg cgttcttttt 3416281 tctaatcggt gccgtgccag gcgtactgca aattatttcc ggtatctttt tgatgaggtc 3416341 agctagggaa gcaggccaaa tggctgaaca caatagcgga cagtctgaag acttaatgct 3416401 ggagaattac gcgaaattcg taaagatgca agggatttat ttgatcgtaa gcattgctgt 3416461 atccattctt gcgattatcg ccttcttcat ctttttaatg cttgggattg ctgacggcct 3416521 tttcagcgat acgtacagca cttattaatg agaaaaaccc ggagctggct ccgggttttt 3416581 tattattccg cttcgcttac cactgtgaag cgttcatttt tgtgttcggg atgttcaagc 3416641 tcgtccaaca cggcaatggc ataatctgca tagctgatat agctgtctcc ttttgcattt 3416701 acgatgacat tgtcttttcc tttttggtaa gagccagtcc gttttcctgc tggatcaaaa 3416761 aatgccgcag gactgaggaa cgtccaggaa atggagtctg tctgctgcaa atctttcagg 3416821 ttctcgcctt gatttgatgc agttggcaaa tattctttcg gaaattccgg cgtatccatt 3416881 aaacgggttg ttttggcttc atcaacaaac aggcttcccg ctccgccaac aacaagcaat 3416941 cttgtgtgct tcgcgtcctt taaaatgctg atgagtgctc ttcctgcttc aacatgaaga 3417001 tgttcttggc cgggtgctgc tccaaaagcg tttacgaccg cgtcgaaagg cttgatgtct 3417061 tccgcagtca gttcaaacac atctttttcc aaaatcgcta cgtcttgctc ctgcactttt 3417121 gaagcgtttc tgacgatggc tgtcacttca tggcctcttt ttttcgcttc tttcaaaatc 3417181 tcgtttcccg ctttcccgct tgcgcctata ataccaattt tcatttttca tttcctcctt 3417241 atttgtaaca attttagtta catgttagcg gtgagaagtc atcccttttg attaaaagag 3417301 atgattcata acatctttta atgacttgct tgccagttca ttttccatcg ctctttgcac 3417361 actttcaaac gtttcatcca gagcgttctg aatttttttc cctaccggac atttcggatt 3417421 cgggttttca tgaaccgcaa agagttcttc ttgcttttgg acagcccggt acacttctaa 3417481 aagagaaata tcagcaggat cttttttgag gcttgcaccc ggcaccccgg cgcgtgatgt 3417541 gagaatatca gcttttttca gcaggctgat cattcttcgc acaactaccg gattcgtgtt 3417601 gacactgtct gcaatgattt ctgaagatgt tttttcatcc atcgagatga gggataaaat 3417661 atgaatggca acagcaagac ggctgttaat catgtttttt caccaccgtt gtaactataa 3417721 tagttacatt tgattcgttt gtcaacatct aatatacact aaatacatgg gttttgtgca 3417781 ccgtttttag tcaatagaac ggccggatgc actccggccg cgtcttatca aaataagaaa 3417841 tatctttgtc caagtgggac ataatcgaca ggctggcaag acaattcctc cccgtcagca 3417901 aagacctgat aggtttttgg atcaatctca atcttcggca aagccgaatt cagcttcata 3417961 tccagcttgc tcagctttct gatatttttg actggagaaa tccttttttc cagccctaag 3418021 ctttccgcca caccacgctc tatgcttgcc tgagacataa atgtaatcga ggttgagcgg 3418081 ttggcttttc cgtaagacgc atacatttgg cgcatgaaaa ccggttcagg agtcgggatg 3418141 gacgcgttcg gatctcccat ttgcgcacgt gcaatcatgc cgccctttaa gaccagttcc 3418201 ggtttcacgc cgaaaaatac cgggtcccac agaacgagat cagcaagctt ccctttttcc 3418261 accgagccga cctcatggct gagcccgtgc gtaattgccg gattaatcgt gtatttggca 3418321 atgtaccgtt ttgcgcgcac attgtcattc ccgttttcac cggcaagagc gccgcgctgt 3418381 tttttcattt tatcggctac ctgccatgtt cggatgatca cttcaccgac ccgccccatc 3418441 gcttgggaat ccgatgatgt catgctgatc gcacctatat catggagaat atcctccgcg 3418501 gcaatcgtcg ccgccctgat tctggaatgg ctgaatgcca catcttcagg cactttcgca 3418561 tctaaatggt ggcagaccat catcatgtca agatgctcat ccatcgtatt aacggtataa 3418621 ggaatggttg gcgttgtaga tgacggcaga atgttcgcgt aagaggcgag cttcataata 3418681 tccggagcgt gaccgccgcc tgccccttca atgtgataag tatgaataac ccggtccccg 3418741 atcgcgtcga gcgtgttttc caaaaagccc gcttcgttaa tcgtatcggt atggatggca 3418801 acttgaatat cagcctcgtc cacgacttcc atacacgttt taatggcgct tggcgtcgtt 3418861 ccccagtctt catggagctt aagaccgatg gcgcctgctt ccacctgctc gatcagcggc 3418921 gctttatcgg atgcattccc ttttcctaag aagccgacat tgatcggaaa ctcctcggcc 3418981 gcttccagca tcctcgccat ataccacgcc ccggacgtac atgttgtcgc tttgcttcct 3419041 gtagcgggtc ctgttccgcc tcccaaaagg gtcgtcacac ctgaagaaag cgcaacttcc 3419101 atctgctgag gacaaataaa atgaatgtgc gtgtccactc ccccggctgt taaaattttg 3419161 ccttcaccgg aaatcacctc tgtccccgct ccgatgacca tgtgcggatc gactccatcc 3419221 atgatatcag gatttccgct ttttccgaca ccgacaatcc ggccgtcttt cacaccgaca 3419281 tccgctttga caatgcctgt gtaatccaat agcacgacgt tggtgataac caaatccaaa 3419341 gcgccgtcct tccctgtgat tctgccgttt tggcccatgc cgtctcggat agtttttccg 3419401 ccgccaaaga tcatttcttc accgtatact gtgaaatcct tttcgacttc gatccataaa 3419461 tccgtgtcgc ccaatctgat tttatcgccc gttgtcgggc caaacagttc cgcatattcc 3419521 tcccgtgaca ttttcatcgg attacaccct ccatccagcc ggcttgtttt aagttggcca 3419581 acgttttttc tttgccgcgt tcatcgataa acgtgtcggc cattccgttc agccctctaa 3419641 ttgtcttgcg tcctctgatt tccactagtg agaccgtttt ctgctctccc ggctcaaaac 3419701 ggaccgacgt gcctgatgga acatcaagac gcatgccgat cgccagctca cggtcaaata 3419761 ataaagcccc gttggcctcc gcaaaatgaa aatgcgaacc gacttgaatg gagcgtgatc 3419821 cggtgttttt taccgttacc tcccgtatct cacggccttc attaatcgta atggttccct 3419881 cagcaatttg aaatgctccc ggcttcatga cttcacctcc gcagaaattg gctgatgtac 3419941 cgtaacaagc tttacaccat ccggaaatgt ggcctccacc tgaatgctgt ccagcatctc 3420001 aggcacaccc tccatcacat ctttttccgt taatacatgg cggccggctt ccatcagctc 3420061 tgctactccc ttcccatcac gtgcgccttc cataataaag caggtgatat aagcagcagc 3420121 ctcaggatag ttcagcagaa cgccccgcgc ctttcgctgt ttggctaatt cccccgctgc 3420181 aaaaatgagc aatttctctt gttcaactgg tgtcagtttc atctgtagtc ctccttcttt 3420241 tgtcatataa agcagatgcg gctactacga atttgcggaa cagtcaggcg ggacatcacc 3420301 tccctttctt cgagaatggg ggtcatacgg taagatgcct ttcaaagcgg catgccgttt 3420361 cttcatcagc cttgccatgg tcaacaaccg ttcccctgtc gatcacggaa agatcagatt 3420421 aacgcgtttt ccagactgcg ctcgactaag ataacaaatg tctttttttc tggaaatttc 3420481 tataataact tgtctgacta gttcgacaat taaaatctga attccttcca attgtttatt 3420541 aagtaaaata tttttcagat ttaccatcag cgctctggtg attgcaagct gctgctgttg 3420601 accgcctttt cgttttgaac aaacgtttga ttaaaacaaa tagccccctc tgtttagccg 3420661 gagtcggcct aatacagcga caatctgccc cgggcgaagc taaggctgtg caaaaccatc 3420721 gattgatcat aaccagacgt tacattcctg atggcagccc gttgttttgc tccgcaaccg 3420781 gaagcatggc atggaggcca gtctgaggcg ccgacctcca cgataccgag aacccgacta 3420841 ttgccattaa ctccgcatca tggacggtca cttcgctgat cgccaccgtt cctcttaatg 3420901 agtgaagaat tccggccttc actgaatccc cgcttgtgtc gatatcaact gttttctcgc 3420961 actcccgtgg cttccgacac tttcttcggt gcagtacatt ccgtcatcaa aacccctttg 3421021 tttgatttct tcaaatgatg ttataaaagt ttacaactta tgtcatcatt atatagaaga 3421081 ggcctattaa ttcaaagaat atttaaaaaa tttagttacc ttgaccaaat cagcttcttt 3421141 ttttgttata tttattcaca tcagaaaaag cgaaaaaaaa agacaagaaa catttcgttt 3421201 cctgcctctt ccgtacgatt aatctttatc tgaaaattta tccttggctt tcccgatatc 3421261 cttttggatt tcgccttttg ccttatcttt tttgccttca gcctgcatgt ccgttctgtc 3421321 agccatatct ccgactttat ccttcacttc tcctttggct ttattgaagc cgcccttcat 3421381 tttgtctttt acactatcgt tacccatgtt aattctcccc tctcaattat gtgtgtactt 3421441 gttaacttcc cgatctgaga ggcaataaac attctaatgt tatttatcga tttcgtagcg 3421501 ctctccgtaa cggagcacct tgtatatcgc cagcccgtct gatgactttt tctccgaata 3421561 tcggaccggc agcagggcaa aaaacacata atacgtagaa aaatagacaa actgatagaa 3421621 aaacacattc ggctttaata cactgtgtat aatcagcaga ttgattgcaa aaatcgtgat 3421681 gaggttaaac aagcagcccc ctgcatacac gagtgcattt gagaatcgat tgtcaatttt 3421741 caactccccg taccggcaaa aagaatcgat aaaataaatc gttctgaacc gtatgggtcc 3421801 aattttaagc agcgtttttc ccatgcctat atccaacgat ccctttccgc caaaaataaa 3421861 agccataaag ctgtgccctg aaacatgtat aatctgtaca agcggcagaa caatgaggaa 3421921 agaccacaga aacttcacca tatcattaaa accaaacatt gaattccccc tcacatgcat 3421981 atctgcatcc caaaacggct tttgttcaaa aaacagtgct gtagcgattt ttcctgttct 3422041 ccccggaaat aaacgttccg atgctcccct ttttttgcat aaaaaaaaac catctgccag 3422101 cagatggttt tgtctcatac ttcatataaa caatcgttcc tttgaatcat ctctctcatg 3422161 ctgaccgctt tttcataaaa atacaccgct tctttatatt gttcgcgatg actgaaataa 3422221 gaggcagcat ctaaagcaaa ttcttcaata tatacataca ggcccttttc ttccatataa 3422281 tcaaatactt cttgaatcat attcaaattg acagattcca catataatgc ctgcagaaat 3422341 ttatattttg ccagactgaa gaagtcgttt cgtttttggg caatggcaat ccctttttca 3422401 tagtaccgta tcgcggcttc gctatcttgt tttttgaaaa gaacgcgagt caggctgaag 3422461 agcgcttttg gaagctgttc cagctgataa tcctcgaaga caggaagcgc tttttcaaag 3422521 tattcggcgg cctgatccag ctcccccttg tcatcatagc aattaccaat attataaagg 3422581 gctgatccga tcaaacgggg ctgtccttcc aataaagcaa ggcgatacgc gtcatctaaa 3422641 tgttcaagcg ctttttcata atttctgtag tcaatgtagt ttcctgatat gacgaaatgg 3422701 cattgaattc ttctgactct gtaaaaatcg tgagccttat acgtctccag cgcctgtacg 3422761 gcatggttca tggaaaagtg cgtctgcttc ataatataaa agacttccgc cactttaaaa 3422821 tgaaattccg ctctttcaat ttcatcttct acaaacgcaa gcatcttctc agctttccga 3422881 taaaaggata tagccgagat gtaattgttc tgttcaaatt cgtacattcc tctaaacaag 3422941 tgaaaataat actcagataa tccggagatg ctgtcctgat tgctttccag cgttttgatc 3423001 aattcacgat attgaagctg agattcctcg tgcaggtcag gctttacata atccagcata 3423061 atttggtgcc ggtagctgat cagctgataa tacaggagaa gcagctgatc ctcttccatc 3423121 tgttcgatat ctagatcaat ttcttctttc agttttacgg catcagccac ttgaaatgct 3423181 aaaatgtgct tataccactt attgattttc actcctactt gagatgacgg gatctcgtac 3423241 gcggccatgc ccctccaacc ctttctattt tctaattggt tatattttat cataatgtat 3423301 ggctttggaa ttaaattttc ttacaatgat tccttcttta tgcctatcct tatatatttc 3423361 ggtttttcta cgtatttttt gcactcggat tctaataaaa aagcttaccg gacagtgccg 3423421 ataagctttt gacttcaaat taaccgccaa tataagacat ttccactttc tttttgccag 3423481 atgcttttga tagcgtacga tcgactgaat actgatcgat ccgatttttc catactgtcc 3423541 cgatcatttc tgatagttcg tcatcactta attcctggcg aaccggagct ctgaggtcaa 3423601 atccgcttga agcgaataag caggtaaaca gctctcctct cgcagaaaga cgggctctgt 3423661 tgcaagatcc gcagaatgca tcagatacag atgatatgac gccaatttct ccggagccgt 3423721 ccaagtagcg gaatctggaa gccacttcgc ctatataatt aggcgctatc ggctcaaccg 3423781 gcatgtgttt attgatcaaa tctatgattt ccgcctttgt catgacgtct ttcttttccc 3423841 attggttggt gttgcctacg tccataaatt caatgaatct caggatatgc cctttttctt 3423901 taaaataacg ggccataggc agtatatctt tttcattgac gcccttttga acgaccatat 3423961 tgattttaac accgagcccc gcttgcttcg ccgcttcaat gccttccagc accttgctga 3424021 cagaaacacc gcgcccgttt atcttcttaa aacgctcgtc ttctaaagaa tcaaggctga 3424081 tcgtaaccct tttcagccca gcctccttga gcctcttagc ataaacaggc agcagtgatc 3424141 cgtttgtcgt catcgcgatg tcacgaatac ccggtatgcg ggccagtttt ttgattaatt 3424201 ccggcatatc ctttctcatg aggggctctc cgccggtcaa gcggattttt tcaacgccaa 3424261 atcttgtgac aaacaatgtc gcaagccgtt ccagctcctc aaatgaaagc agctcctctt 3424321 tctttaaaaa aggataatcc gggccgaata attcggcggg catacagtac gtgcatcgga 3424381 agttgcagcg gtctgtaaca gaaatgcgaa ggtctctcag cggtctgttt cttttatcca 3424441 acatctgacg cgactctgta atcatagcta cagccccttc ctactccctg attctctcag 3424501 ggtgtgtata tacattaaat gatccgtttc tgacaaatcc aatcgctgtg atattcaatt 3424561 cttcagccat ttgaatcgca agctccgtcg gggccgattt ggaaatgaca atcgacacgc 3424621 cgattttggc cgcttttaac aggacctctg atgagattct gccgctgaac acaatcagtt 3424681 tgtcgcgtac ggacatcccg tttagaaggc agtgtccgta tagtttatca agtgcgttgt 3424741 gccgaccgat atctgtgcgc atcaacagaa gcttctctgt gtcgcaaagc gccgcattat 3424801 ggacgcctcc cgtatcctga aacgtcccgc tcccttgctg catgtctttc ataagcgcca 3424861 gacatgcctc aggcgatatc ttgatttggc tgacagccgt cttggctgtt ttgacatcct 3424921 gctgaaaata aaaatgacgg ccctttccgc agcatgagcc gatcacccgt ttcgtataat 3424981 ccttttgatc caatgtctca gggtgaacga ggtcgacata tacaaaaccg agactttcat 3425041 ctattgtaaa ccttttaatt tctttttgaa atcgtataac accctctgat gcgagaaatc 3425101 cgatgacaag ctcttcgata tgctcaggcg tacaaacgag cgtcacaaat tcactgccat 3425161 tcagtatcac tgtcaaaggg aattccgtca ccatccggtc ttctactttg cttatttccc 3425221 cttgttcata gcgccataca tccctgaccg cagttacttt atcgttcaat gtctcttccc 3425281 ctccgcaatg ttcctgcctt tatatttttt cacactcctc ggattttgtc gaattctgag 3425341 acacaaaaag agccctctat ataaagggct tttacaggat gtgatgacgg cggtgtttag 3425401 gcaggacgcc taagcattta gccgccgttc cttttataac acgtgagcac caatgtgcat 3425461 tgacaacgaa cgcggggttt gtcgacacgc tgagacacct ctgtataaag gactctatgt 3425521 ttgattatgc tgattctttt tcagaaccgt aaacagcaca atagctgcga tcaaggtgag 3425581 aatgctgaca aaaaagaagg ctgccagttt tagaagaaca ccaagcaata taaatgcaac 3425641 ggtggctata agaaaaatca ttccgaataa tttcatatgt tcaacccctt tttagggtat 3425701 cattcccgcc caaactgttt ttaaaccaat aaaaaaggcg cctgggggag cgcctgatct 3425761 ttaggttcct tactcagtaa atttttgtgc ttctttttcc caagcctgtt cgaactcatc 3425821 cgcactgttc gctgaaatat attctccgcc gccagcgaca gctgcttgtt tcatctcttc 3425881 attacccttg acatcaaagt tgaagccaat gatgtttaca atcgtatcca catttgatgc 3425941 acggagcttt tcgatttccg ccgcagggtc tccgccgcac gtttcttcac cgtcagtgat 3426001 taaatacacc acgtttttcc cgtctgcgtc aaatgcttca aattcttttc ttgtgtctgc 3426061 aagtgctttg gcaatcggtg tccatccagt cggcttgagc tcactcaatg aattgtcaaa 3426121 cagagaccct tcatatggat gaaggccgta aatggtttcc gtcgtactgc acgaaagggc 3426181 tttaccggac agtttattgt tccctgcatg cccgaaaacg cgaagcataa gatttgtatc 3426241 ctttggaaga agttcggcaa aagattttac tgattttttg gcaatgtcta ttttgcgctc 3426301 tcctcctgtt ttttgaacca tgcttccgct tccgtcaaac aaaacagcta catttgtatc 3426361 agcctgtttc tcagcggcaa aagacgggga ggcaatggaa acagtcaaca atccaatgat 3426421 accggcagcc agcaattttt tcatatgatt acttcctttc tttttcatat tttccaacta 3426481 tatgttggat tcttctttat gctagaatac gaaaatgcaa aaagatatag gacatgctgc 3426541 cttttgtgct gctttcacga tctgtccaaa atcgcttgaa atgccgttca tttttagcca 3426601 tttccgccca gaaagcataa acagcttgtg tgatcattca ttcttttttc gccttgatta 3426661 tgacagaaaa acggaaatct gctactatgc tacaggcaga cagctaatta gttttgaagt 3426721 ttttgttaca tacaaaaaga ggctgaccat caccagcctc ttttttctta tttagataac 3426781 attagtgatt gctgagtgaa aattttctca acatcttttt gggtataagc cgggaagtat 3426841 tcaccgccgc ctactttcgc aattgcgttc agctggcctt tgtatccctc tttataatca 3426901 aagccgatca cattaacagt gatattgtct ttttgcagtt cctttgctgt tttaatcggg 3426961 tttcctccgc acgtttcctc accgtctgtc aacagataca ccactttttc cccttttgca 3427021 tcaagctggt caaaagaaga tttcgcctcg ttcagcgctt tggcaattgg cgtccagcca 3427081 gtcggcccaa ttgtattgag agaattgagg aagctttgct cgttaaagct ttggaagccg 3427141 tatacgttgc gaatggcttc acatgactga acttttccgg aatttttatt gtttccttca 3427201 gagccaaaca cgctcatttt cacctgagtt ccttctggca atgagctcgc aaactttgaa 3427261 atttcttttt tggctgaatt aaatttagat acaccatcta ttcttttcgc catacttccg 3427321 ctggcatcaa gcaagaccgc cacgttcgcc ggcgctttag cctccgtttc tgtcttttca 3427381 gctgcaaaag caggtgaagt taatccaaaa agcaatcctg tcatcatgat cagtgaaaat 3427441 cttttcttca tgttcgtacc cctttaccaa tttgtttctg cgtgcagatg ttcaacgctg 3427501 aacataatct atcgtaatca acaaaaaccg agaaataaat agggcgggct tccccattgc 3427561 tgttgtttac ttttgcatag aaacctatgt ttttattagt gatttccacc taacgcccct 3427621 atgaaaagag aagattgtcc gcctttcggc tttcgttata tgagtctgtc gaagtctgtc 3427681 gacaaatgtg gatgacttta ccacaatctc aaagcctgaa atcaggaaaa aaggactgat 3427741 ccttaaagac ggtcagaagc tcctctaaac cgtttcagct actcttagat aaaagatatt 3427801 caggaacaga aaaagacgcc caatgagcgt ctttttctac tttttcgcca tatatttatt 3427861 caaaaacgca tctgcctcag aaatttgtgt gccttggtaa tagtacttta caatgtcatc 3427921 aaccgttttg ccttctttgg ccataaaatt cgctccgtat tggctcatcc ccacaccgtg 3427981 gccaaatcct ctcgtcgtga ctgtaattgt gtctccattt cgcttccatt caaaatcggc 3428041 ggagttgaga cccaactttt cacgtatgtc tcttcctttc agcgtcttgc cgttaatgac 3428101 ggcagttgcg acctggtggc ccggtgtctc gccggtaatc ttccctactg cgctagatcc 3428161 atccagcttg acgccaagct tttgctgaaa ttctgccgct gtaaaggttt tcgttgcctt 3428221 atatttcgga gactttttat cccatgggct tttgacgctt tttaaatatg ggatagcact 3428281 tgtccaataa gcttctgcat tctctgtgta gccgttgctt gtggagaaaa aggatgcttc 3428341 aatcggctgg ttgttgtacg ttaagatttt gccttgcgta ctggctaccg catctgtgat 3428401 tttcttcagt tttgtctcat agcttgtgcc ccactgtttt ttcagctccg ctttgctttt 3428461 atacacctgg aacatctgtg tatcatccac cagtgagcct ttaggagctt ctaccgctga 3428521 atttgacacc atcagtctga caataaatgt tctggcggca agcgcctggg ctttcagcgc 3428581 ttcaggttta aaggttgccg gcatttcgga ggcgacgact ccaatcacat actcttcaag 3428641 cggaatgttt tctacggatt gatttgcggt tcgatagacg ggaatagaaa caggtgatgc 3428701 tttcaatgtt tctgctcctt tcgatgctgg tttcgtgctg actgctgtct tttctgattc 3428761 tacgctggcc cccgcttcct tattatgctg gaatggtata accaagagtg tgggaaccaa 3428821 gagaatcaat gcacatagta cggatagtgt gattgcgaat tgtttcatat tcagctgcct 3428881 cctgctcggg attcgactct agtctagtct atgggcaggg acaagctaat atgactctcg 3428941 ttttggacag aaactttatt tgtcatttac gtattctttt ttgctatttt gcgcataatg 3429001 atgataatac acaaaaaata aaaaaccagt atgccagagt gacatactga ttttcaagta 3429061 agtttatgca tttaagtcag aaacgacttc tttattctct tgctcagaag cagactcatc 3429121 atttacacgt tcgatgtctg cgcccagagc ggcaagcttc tgatggaaat caacgtaacc 3429181 gcggtctaag tgcttcaatt cagtaacacg tgtgtgacct tcagccacta accccgcaag 3429241 aatcagcgct gcacctgcac gcaaatcagt cgctgcaact tcagctccct gaagctgtac 3429301 aggaccgtta atgatgacag aacgtccttc aatcttgata tcaccattca tacggcggaa 3429361 ttcttccgca tgcataaaac ggttttcaaa aacggtttct gtaatcatgc ttgtgccgct 3429421 tgcacgaagc agaagcgcca tcatttgtga ctgcatatca gtcgggaagc ccgggtgagg 3429481 cattgttttg atgtcaatcg gtttaagctc tttcgggccg atgacacgca gaccttcacc 3429541 ttcatcctta attgttacac ccatctcttc catttttgca attaaagagg tgaggtgctc 3429601 aggaaccgct ccttttacta atacgtttcc ttcagtgatt gcagcagcaa ccataaatgt 3429661 gcccgcttca atacggtcag gaataatatg gtgttttacg ccgtgaagct tttcgactcc 3429721 ttcaattttg atggtgccgg tgccagctcc gcggattttt ccgcccatgc cgttgatata 3429781 gtttgctaaa tcaacgattt cgggttcttt tgccacgttt tccagcgttg ttgttccttc 3429841 agctagagcg gctgccataa tcaggttctc tgtagctcct acacttggga agtccagata 3429901 aatttttgcg ccttgcagtc ggccttttac ttcagcttca atgaagccat taccgacttt 3429961 gatttctgcg cccattgctt caaaaccttt taaatgctga tcaatcggtc tggaaccaat 3430021 tgcgcatccg cccggaagtg caactcttgc atgacctgta cgcgcaagaa gcggccccat 3430081 gacaagcaca gacgcacgca ttttacgaac atattcaaaa ggtgcttcag tttgcaaagc 3430141 gtatgaagca tttacagtca cttcattatt ttcaaaatgc acatctgctc ctaaatgacg 3430201 caacacttcg ttaattgtat atacatcgga gagcgtaggt acatcacaaa ttacgctttt 3430261 ttcttcactt gctaataaag atgcagcgat aacaggtaaa acggcatttt tagcgccttc 3430321 aactttgact gtgccgttta acttctgacc gccgcggacg atgatttttt ccaaggtatt 3430381 cccctccgcg tccctaaatt ctctatatta atattcagtc gtaacgattg gtgtgccaac 3430441 cgtaacggta tgttttccgc ccattcctgc acttctaagt gcaatttgca aattcatttt 3430501 atgtttcgag gtcataatgt actcttccca ctcatctgta aacgcagaaa tagaaacgaa 3430561 atttggctca actacatgtt ctactgatct tgcttgaaat tcatttaata actgatttgc 3430621 ttttttttgc aaaacaatat tcatattatc atctaagtga ccatttagac aagtaaaaat 3430681 aactactttt tcttggaata tcccaagtgt ctcccgttca aactgttcat atgtatcatt 3430741 ccagctatcc ggtgtctcta gactcatttg ctcatataat aaatacgaag ttggattgtg 3430801 ttttttgagg gttgtgacaa gctgcagtct aaaagaagta cgattttttt tgtcagtata 3430861 tgtgccaatt gcctttatca ttttatcttc ccgtgcaatc acccaatcat attgacgata 3430921 ctcttgtttt aaacgttgca ctttttgata aaattctttt tcggtcagtg acaagttttg 3430981 ttttgcatgc aatgtccact tatctattga cacatcttga cgttccatcc cctctgccat 3431041 ctgtgctaac ggcgttaatt cactcgcatg aatggtatgg aaaacagcaa tgacgaagct 3431101 taacatgacg gaaatgataa tagcgtggct tacttgtttt ttcttcatgt tcatctctcc 3431161 cccttatccc cagttttacc ggaggcaaga ggcgccatac gtaaaaatct tcgtcaaaac 3431221 tcgagctatt cgcttcaacc cgcttctccc aaccatttaa taatgttcaa aacctattaa 3431281 aatagatagg gaagctgctg tgaataattg aggtaatcta aaaagaaatt ggcaacggcc 3431341 gttccaatgg cgattgtcag caaaatcatc aggagtcttg cctgcacgac tttgcctttt 3431401 ttgattaacg gatctatatt gacggcttgc aacgcccacc aagtcactgc tataaaaatc 3431461 aggtgaacga caatgccgat tgcagcctgc tgtcccaata cactcatcta ttacactcct 3431521 ttctctgcgt tcataccctt tcttattata taagaagcac agataaagat gatacatttt 3431581 atacagaacg gaataatcag ccaaatctag ggctaatccc cgcttaaagt gcgattcttt 3431641 tacatggtat actttattgg aaaggagctg gcaaatgtga atcattcttt ttttcagcct 3431701 gaaaagcaat atggtgagga cctgccaatt tttgatcagg aatgggaagc aattgcattc 3431761 tattatgatt atagacagtc acagattgaa gaactgaatg aattgtgtca gttttttaac 3431821 atttctctta cctatacgag agaaagcctt gaagagcttg aaaacctcta ttttcaaagt 3431881 atacaagaac ttttgcttgc tgattggaat cttcctattg aagaattcga gaaaatgatc 3431941 agtgtttatc ttatagattg tgtgattgcc cgccatgaag atgctgaatg ggttgtaaaa 3432001 ccttatccct ataaagacgg cgcttataca cttggcttta gaagacatcg caaatcgtgg 3432061 catacaatga atgcctgtga tggtttatac ctgcgtccaa aagaggatcg cccgttgctg 3432121 tcgctgtttg attctcttgt gcgttcataa aaaaatcctt ctcataaaga gaaggatttt 3432181 ttcttatttc cctgctacat ccaatctgtt caaagcccgc tgtaacgcaa gctcagcccg 3432241 acgaatgtca gtatcatctg attgagaatt caaacgctcc tgcgcccgct ggcgtgcagc 3432301 ttcagcgcgc tctttatcga tgccttccgc tgtctcggca gcctgggcaa ggatggtgac 3432361 atgatcagga cggacttcta caaaaccgcc gctgacggca accatttcag tctgcccgtc 3432421 ttttttcaga cggacagcgc cgattttaag aggagccacg gttggaatat ggcctggcaa 3432481 aataccgaga tcgccgcttt cggctctcac actcaccatt tcgatatccg catcgtatac 3432541 tgggccgtcg ggagtaacga tattgacttt aacggtcttc atgcttttac cctcctagga 3432601 ccagattaaa cttctacacc catttctttt gctttctcaa caacttcttc gatacggcct 3432661 acaagacgga atgcatcttc tggaagatgg tcatatttac cggctaagat ttctttgaag 3432721 ccttgtaccg tctcttttac aggcacgtaa gaaccttttt gtccagtgaa ctgttcagcc 3432781 acgtggaagt tctgagaaag gaagaactgg atacgacgtg cgcggtgaac gacaagtttg 3432841 tcttcctcgc ctaattcatc cataccgaga atcgcaatga tatcctgaag ctctttgtaa 3432901 cgctgaagcg ttgactgtac ttcacgcgca accgcatagt gctcttctcc aacaatttca 3432961 ggagcaaggg cgcgtgatgt agatgccaac ggatcaaccg cagggtaaat acccatttca 3433021 gttaatttac gctcaaggtt tgttgtcgca tccaagtgag cgaacgttgt cgccggcgcc 3433081 gggtcagtgt agtcatcggc aggcacgtag atcgcctgga tagatgtaac tgatccaacg 3433141 ttcgtagacg tgatacgctc ttggagctga cccatctcag ttgcaagcgt cggctgataa 3433201 ccaaccgctg aaggcatacg gccaagaagg gctgaaacct ctgaacccgc ttgtgtgaaa 3433261 cggaaaatgt tatcgatgaa gaacagtacg tcctgtcctt gtacatcacg gaagtgctca 3433321 gccattgtaa ggcctgtcaa agcaacacgc atacgtgcgc ccggcggctc gttcatttgt 3433381 ccgaatacca tggctgtttt gttgattacg ccagagtcac tcatttcgta gaaaaggtcg 3433441 ttcccttcac gagtacgctc tcctacgccg gcgaatacag agataccgcc gtgctcttgc 3433501 gcgatgttgt tgattaattc ctggattaat acggttttac ctacaccggc accaccgaac 3433561 aatccgattt taccgccctt aatgtaagga gcaagcaaat caacaacttt aatacctgtt 3433621 tcaagaattt caacttctgt tgaaagctga tcgaatgaag gcgcctgtct gtgaatcgga 3433681 tcctttttcg catccgcagg aaccggctca ttcaaatcaa tattttctcc gagaacgtta 3433741 aatacacgtc caagtgttac atcaccaacc ggtactgaga ttggcgctcc tgtatctaca 3433801 gcttccatac cgcgctgaac accatctgta gatgccattg cgattgtacg gactgtatca 3433861 tcacctaaat gaagagcgac ctcaagcgtt aaatcaatac ctacttcgtt ttcacttgca 3433921 gctggctgtg aaattttaat cgcattataa atttcaggca agtgaccgtc ttcaaaacgc 3433981 acgtcgacga ccggtcctaa tacctggcta acgcgtcctt tcttcatcgc tatccctcct 3434041 gacaaaatct ttctattcta aagcggctgc tccgccgaca atttccgtaa tttcttgtgt 3434101 gatggctgct tggcgagcgc ggttgtaaga aagcgaaagt gaatcgataa gttccttcgc 3434161 gttgtctgtc gcgtttttca tcgccgtcat tcttgcagcg tgctcacttg ctttactgtc 3434221 aagaagcgca ccgaagatta agctttctgc atattgagga agcaaaacct ccagaacctc 3434281 ctcttcagat ggttcaaatt cataagacgc cgttcttttt ccgccgccgc tgcccaaatc 3434341 agataacggc agaagttttt tctccgttac ttcttgagta atggcgctga caaaatggtt 3434401 ataaacaagg tgcaattcat caaacgcacc gtctataaac atttgaatcg tttgacgggc 3434461 aagatcttta atttctgtaa acgttacttc atctccaagt cctgttaact cggaaatgat 3434521 cggaatctcc cgtttcttaa agaaatcacg gcccactctt ccgatggcaa tcaccgcata 3434581 ctcatcctta gactgatgac gttcttgcat ggcctgataa gcactccgta aaaccgaact 3434641 gttaaaagcg ccggcaagac cgcggtcaga cgtaatgaca aggtatgccg tttttttcac 3434701 ttctctgctg agaagcatcg ggtgcttcac gttgccggaa actcttccga cgtttgacac 3434761 aacctcttgg attttatcca tatatggcac aaatgatttt gcattgtttt cagcacgatt 3434821 cagcttagcc gcagatacca tctgcatggc ttttgtaatc tgacttgttt ttttcgttga 3434881 cgtgatcctt gacttaatat cgcgtaatga ggccaaagat ttcaccacct tttctcttca 3434941 tctgcgtaaa aagagagaaa aagagaacct ttttctctca tcagcattcg agttagttgc 3435001 ttggtgcaaa tgtgcgtttg aagccttcga ttgcagcttt gaagtcttca tcagcaggaa 3435061 ggtttcctgt tttcgcaatt ccgtcaagca ggtctttatg gttttggtca aggtacatgt 3435121 agtactcttc ttcaaaacgt ctgatatccg ccacaggaat atcatcgaga tatccttttg 3435181 tcagcgcata aagaatagct acttgctttt caaccggaag cggcttgttc agatcctgct 3435241 tcagcacttc aactgtacgc gcaccgcggt tcagttttgc ctgagtcgct tggtcgaggt 3435301 cagaaccgaa ttgagcgaat gcttccagct cacggtatga cgcaaggtca agacgcaaag 3435361 tacctgatac ttttttcatc gctttgattt gcgctgagcc gccgacacgg gatacagaca 3435421 atccggcatt gatcgctgga cgtacgcctg agaagaacaa atcagattgc aggaagatct 3435481 gtccgtcggt gatggaaatg acgttcgtcg gaatataagc agagatatct ccggcttgtg 3435541 tttctacgaa cggcagagct gtaattgatc ctgcgccttt cgcgtcgcta agctttgctg 3435601 cacgctcaag cagacgggaa tgaagataga atacatcccc agggaacgct tcacggcctg 3435661 gcggacggcg aagaagcaag gacagctcac ggtaagcggc cgcttgttta gaaagatcat 3435721 cgtatacaac aagaacgtgc ttgccgttgt acataaattc ttctgccatt gtaaccccag 3435781 catacggtgc caggtacaga agcggtgccg gctgtgacgc agacgccgtt acaacaattg 3435841 tataatcaag cgcgccgtgt ttacgcaatg tttctactac gccgcggact gttgattctt 3435901 tttggccgat cgcaacatat acacagatca tgtcttggtc tttttggttc aggatcgcat 3435961 cgatcgcaac agatgtttta cctgtttgac ggtcaccgat gatcagctca cgctggccgc 3436021 ggccgattgg aatcagtgca tcgatcgctt tgataccggt ttgaagcggt tcatgaacgg 3436081 atttacggtc cataacgcct ggtgcagggc tttcgatcgg acgagttttg cttgtcagaa 3436141 tcgggcctag tccgtcaacc ggctggccta gcgggtttac aatacggccg attaactctt 3436201 caccaacagg aacctccatg atgcggcctg ttctttttac ttcgtctccc tcacggatct 3436261 cactgaaagg tcctaagatg acgataccta cgtttgattc ctcaaggttt tgagccatac 3436321 ccaaaacacc gtttgaaaat tcgacaagtt caccggccat acagttgtca aggccgtgca 3436381 cacgtgcaat accgtcaccg acttggatga ctgtacctac gtcttgaact tcaatatcag 3436441 attgataatt ttgtatttgc tgttttatca gcgtgctaat ctcttcagct ttgatgctca 3436501 cttaggtttc accccttcta tcgattttcc ccggctaatt gacgttcaat gcgctgaagc 3436561 ttcccgctta cgctgccgtc ataaatccgg tttccaatgc ggactttaat accgcctatt 3436621 aaatccgtct gcacttcatt tctgattctc agtgaagcga ctccggcttt ttttgcaaac 3436681 acttgtgata atggtaacat ttctgcatcc gtcagcggtt tcactgaata tacgattgcg 3436741 tcttctgttt gacgggccac atttgcgagt ttgataaact catctgtgag ctcagggaca 3436801 atcgcggcac gatggcggtc aatcaaaaga aaaatcgtat tgagtacgga ctgtgacaaa 3436861 gagccaaatg cattttgaat cagctctttt ttcttcgcag ccggcacctt cggatggttc 3436921 aacacatcat taagcgcttt ttcattttga aatacttgtt ttacaacaat tagctcttct 3436981 tctacttgat tcagctgagc ggactcattg gctatatcaa aaagagctga tgcatatcgt 3437041 ttagagacag ctgatccact catcggcttt ctcctacctc tttaagatag tcctggatca 3437101 atttctcttg cgcttgttca tccagttctt tttcgatcac tttcgacgca atcatgacag 3437161 aaagagacgc tacttgctca cggagagcag aaaccgcctg ttccttttcc ttcacgattt 3437221 cagttcttgc tgcttctttc agacgttcag attctgcacg tgcagcctga ataatctctt 3437281 ctttttgctt ctctcccagt ttctttgcgt tttcgataag agtttgggat tcctgtcttg 3437341 cttcttttaa aagaacgcgc tgctcttcaa tcagctgctg cgcttcttta tttttttctt 3437401 cagcagacgt aatttctcca gcgatgtggt cttcacgctg tttcattatg tttaatagcg 3437461 gccctaaagc gtatttcttc agaagcgcta ataagattaa catagctaac agttggaaca 3437521 ggatatctcc gccgttaaac gacaatccta gttcaagtgg taattgagac atctactacg 3437581 gcaactccct tctgcaggtt tttctttgct gatccagcag ccgcacttgt ctcttttcag 3437641 ccggcaaggc gggatgctta tcagacataa agcaatggcg aaggttctct tggaatgatc 3437701 ttcgccattt ttagttcata taaggctttt atgcttagcc aaagaacgct aagaatgcga 3437761 taacgacagc gataatagga agggcttcaa ctaatgcgat acccatgaac ataagagttc 3437821 tcagttcttt acctgcttcc ggctgacggg caatcccctc taccgtacgt gaaacaatca 3437881 aaccgttacc aatacctgca ccaagtgcgc ctaaaccaat tgcaatcgca gctgctatta 3437941 aattcatgaa aaagttcctc ctttaaaatg ttatccgttt ggatataatg ttttaatgat 3438001 catgactgat tttatgagac atgtacacca tcgtcagcat tgtaaagata aatgcctgga 3438061 tagcaccaat aaataaactg aatgcttgcc atgccagcat cggcagaatg gcaccgattg 3438121 taccgacaag accgagagcc acgctttgcg aataatggct tgttgctaat cccgcaagca 3438181 ggccgagaag aatctcaccg gcgaagatgt taccatacag ccgcaaacct agagtcagcg 3438241 tattcgcaaa ctcttcgatg attttcatcg ggagcatgaa tggaacaggt cttaaatagt 3438301 ctttggaata ttccttgagc cctttcatct tcacaccata gtagtgggtt aaagcaacaa 3438361 ccatcacggc tagcgttaat gtaatggcag gatcggctgt cggagacttc caccagagct 3438421 catgtccgat tgtaatagag aacggcagcc ccagcatatt cgacacaaat atgtacatca 3438481 gcaatgtgac accaagtgcc aagaagttag cccctgtttt taaatccatt gtactgccaa 3438541 taatattgcg gacgaaatca acaatccatt ccataaagtt ctgggctttt ccgggacgga 3438601 tcgaaagcgt tcttgtcgtc aatatagcaa tcaataaaac aatcacactc gccacagtaa 3438661 tcatcagaat gtttgtcaga ttaaaagtaa gacctagaaa ttctatagtt ctgtaaccat 3438721 gattcaaagg gttttcacct ctcttccatt gatgaacgtt taagctggat aaaggaatct 3438781 atcataatga cagggtatat tgtcattaat ccaataactg tacttgccat atgaaagtat 3438841 tcgggatttt tataggcaac agccacagca agaatcgcat tgcaccaccg cgctgcgctc 3438901 ccgagagatc gtatggactt tcctttctct acagctctgt caaaagcatt cattcttctg 3438961 acgagcagta aaaaattaaa caaactgaaa acagttccca gaataaggcc taaaaaaacg 3439021 gttttatacg ctgttaaacc ataacccagt acatacactg ccaaaatgaa caataaatat 3439081 ttgcgttgtc tgctaaatgt aagcttggga tcgtccatca attatctgtc tcctgatgaa 3439141 aaaataatgt atagcttgga tacggcaaaa atcagcggtt aacccttagt agaagacctt 3439201 ttttgaccgg caaaacgggc ctgttcgaaa aaatcattca tccgcaagcc ttgcagggat 3439261 gctgtttcat tcgcttaaat aaatcctcat aatacgggtt tgctgagagg atttacattg 3439321 aggatgagga ctataatgaa agctatgaaa accttctcat aataccctcg tttagcatac 3439381 aatagcccct aacatgtgtc aatctgttta aagttaaaaa actttttata ctttacgtct 3439441 ccacagaatg ttcacatttt cacctataat tgtatacaga ttcaccgaat agcaaaaaac 3439501 tggataaaaa aatgaaaccc ccttttgggg atttcatttt ttattttgtt ccaaacatgc 3439561 ggtcacccgc atctccgaga cctggaacaa tatatccttt ttcatttaat ttttcatcta 3439621 gcgccgcaat gtaaatatca acgtccgaat gatgcttctg caattcttcc acaccctccg 3439681 gcgctgctac aagacacatg aaacggatat ttttcgcacc gcgtttttta aggctgtgaa 3439741 tggcttcaac tgcggaaccg cctgtagcga gcatcgggtc aaccacgatg aattcacgct 3439801 cttccacatc agaaggaagc ttgacatagt attccacggg ttttaaggtt tctggatcac 3439861 ggtaaaggcc gacatgtccc acttttgccg caggaatcag ctttaaaatg ccgtcaacca 3439921 ttcccaatcc tgctctgagg ataggaacca ctccgagttt tttccctgag atgactttcg 3439981 atttcgcagc ctgaaccggt gtattgatat ccacttcttc cagaggaaga tcgcgggtaa 3440041 tttcaaatgc catgagtgta gccacttcat ctactaactc tctaaaatcc ttcgtacctg 3440101 tattttcatt ccgtatatat gtcagcttgt gctgaattaa aggatgatca aatacataaa 3440161 cctttcccat actgtgtttc agctcctttt ttattgtccc atcaacaatt acacacttct 3440221 attgattcta caaaaaaaga cattgagttt caagaacatc gtcaaaaaac ccgccgggca 3440281 taagcccaag cgggttttag gatcttaata atctaattct ttatataaag gaaatttatc 3440341 agtcagagca gctacacgct gtcttgcttc ttcaagtttt ccttcatctt cgtggttttt 3440401 caatgcaagc gcaatgatag caccgacttc ttctaatgcg tctccgtcaa aaccgcggct 3440461 ggttacagca gctgtaccaa gacggatgcc gcttgttacg aaaggttttt caggatcata 3440521 tggaatcgcg tttttgttag acgtaatacc aatttcatca agtacatgct ccgcaacctt 3440581 accagtcagt ccgagcgaac gaaggtcaac aaggataagg tggttgtctg ttccgcctga 3440641 aacgagctgg atgccctctt tcgttaaggc ttcagccaga cgtttcgcgt ttgaaatgac 3440701 gttttgtgca tatgttttga aatcgtcctg caatacttca ccgaatgaaa cagcttttgc 3440761 ggcaataacg tgcatcagag ggccgccttg aattccaggg aagatcgatt tatcaatttt 3440821 cttgccaaac tcttcacggc aaaggatcat accgccgcga ggaccgcgaa gtgttttatg 3440881 tgttgttgtt gtaacgaaat cagcgtaagg aaccgggttt ggatgaaggc ctgccgcaac 3440941 aagtcctgcg atatgtgcca tatccaccat gaagtaagcg ccgacttcat cagcaatttc 3441001 acggaatttc ttaaagtcga ttgtacgagg atacgcactt gctcctgcta cgataagctt 3441061 cggtttatga gcgagggctt tttcacgcac gtcatcgtaa tcaatatatt gagtttcttt 3441121 atctacgccg tactcaacaa agttatattg aacaccgctg aagttgactg ggcttccgtg 3441181 tgttaaatgg ccgccgtggg agaggttcat cccaagtaca gtatcgcctt gctccaaaat 3441241 cgtgaagtac actgccatgt ttgcttgtgc gcctgaatga ggctgaacgt ttacatgctc 3441301 cgctccaaag atttccttcg cgcggtcacg ggcgatatct tcaacgacat cgacgtgctc 3441361 gcatccgccg tagtagcgtt tgcccggata tccttctgcg tacttatttg tcaaaacaga 3441421 tccttgtgct tccataaccg cttcacttac aaagttctca gaagcaatca attcgatctt 3441481 agtctgttgg cgttcacgct catttttaat ggcgttaaac acttgttcgt cttgcgcagg 3441541 taaatgtttc atcagcgaga tcctctccta tccgtatcct gttctttgtt tttaccatca 3441601 ctattgtaca tggtttttaa ggccgatgta aaagattatt tttaaaaaat ctaaattttt 3441661 attggtaaaa acgaatatta ataacttaaa tttaatttaa agttcggaat ttatttcact 3441721 atcttaaaat aaaagaaaag actggctatg cagtcctttc attcgcactc ataaaccgcc 3441781 cgcactccgc cgattagttt cggccgtgta cgcgccaatg tcacatgagc tgaaccgagg 3441841 ctgttttgag agacacgcac agggacagcc accggtttca gatgcatgcc gataaacgta 3441901 tcgcctatat caattccggc gtcagcctga atggtttcaa caagaacagg agacttcatc 3441961 tgcttaaacg cataagacgc catcgctccg cccgcttttg gaacgggcac ggcagaaacg 3442021 gttggaagcc tgaacagctt ggctgtttct gcttcgacga caagcgctct gtttaaatgc 3442081 tcgcagcatt gaaacgccag atggattccc gttttttccc ggagctcagc aagtccgctg 3442141 tagatgcttt cagcgatatc tacactgccc gatgtgccga tccggctgcc ggccacttcg 3442201 ctcgtgctgc atccaaggac gaagagctga tcttgtttca attccgcttg gtcctgaaac 3442261 tcagacagca tcgtcttcca cgtttgtttc aactcattca ttaaacagca cccctacagg 3442321 tttttctctt cataatcgga gatttttcca atacgcgttt ggtgtcttcc cccggtaaac 3442381 tcagtagtca gccagatttt tgcgatttcc cgagccaaac caggtccgat cacccgttca 3442441 cccatcgcaa ggatgtttgt gtcattatgc tccctcgtcg ccttcgcgct gaaggtatcg 3442501 tgcgccagcg cgcagcgaat cccttttact ttattagcgg aaatgctcat gccgatgcct 3442561 gtcccgcaaa ttaaaatgcc tctgtcaact tcgccgctaa ccactttttc ggccaccgga 3442621 aaagcataat ccggataatc gacagagccg ctgccgcagt cacagcccat atcaatatat 3442681 tcaatttgca attcgtccat taactctttg atttcatttc gaatgtgaac gccgccatga 3442741 tccgatgcaa tggctacttt catctgcttt tcctcccagc gtgtgtgatg cggcccgccc 3442801 gctttattga ccgcgcagcc tgtccgctct ttgattcaca ccatatgatg tgcttttcac 3442861 tatattctac tccttcacgc aggatttgca aatgacctgt ttgcagattt tctgacaact 3442921 tatctacggt cttttttcag ctgttttgcc agctgccgaa gaagctcttc aagctcatct 3442981 cgcgtttgtt tatagatgtc aattgagccg ccgaacggat cgaggacatc accatggctg 3443041 cctgtgacat attcttttaa cgtaaacact ttatcacgat aacgtccaaa ttggctggca 3443101 atgatctgtt tgtgctgatg ggtcatagcc agaaccaaat cagccgattc cataagttct 3443161 tcagttaatg gagaagacac atgattaagg gcaatgtgtt tttcaaacag cgcttcgact 3443221 gcatgaggcg tcgctttccc attaggtgaa gcaaacacgc ctgccgagcg gacattgaca 3443281 ttcagccctt ccctttctgc aattgattta aaaagcgcct cagccattgg gctgcggcac 3443341 gtatttccag tacagacaaa aataatatcc atgtcagtca ccccttattt ttctctatta 3443401 tatatgaaga aaaaagaaac ggcgacttcg tttcttttat tggtatatta aattggcaaa 3443461 agcagcttta atccaaacac gattaatatg atgcccccga gcgcttcgct gtatgtgcca 3443521 agccatgact gcacttgttt tccgaccagc aggcccagcc atgtcaacat catgctgaac 3443581 agcccgaaca gggtaattgt gaggagcgga tgcgagccgt atatccccaa gctcaagccg 3443641 acggaaaagc tgtcaaggct gacgccgatg gcaaacagca ataagcccgg ccctgccggt 3443701 gacatgaatc gttcttctga ctgtttaaaa gaggccataa gcatttgaac cccaagaaca 3443761 aaaagcagcg ccccaccgat ataaaccgct aacacgccga ggagccctga cagcatgtta 3443821 ccggccgcca tccctgcgag aggcatgatg acgtgaaaga ggccgatgat gaaaccaata 3443881 tagaatatct gcttctttct aagtttgacc atgcccattc caaggccgac agaaaaagca 3443941 tccatcccta aagcaaacgc catgatgctt aatgtaatca gttcgcctat aaacaaatcc 3444001 gacatacata aataaccccc ttggacacgc cccgcttttt tagcctatgc gtgtccaaaa 3444061 agggttagaa catctgactg ctttcagcga atcactcttc ctccggcggc tttcatcagc 3444121 ctgttcataa tagcaagacc gacacctgta tccggaaagg attccgctat aatgaaatcc 3444181 accttattct catcaaagct gcgcaaagca tcatacagcc ctgccgcaac agtctcaagc 3444241 tgagcccgtc ttccgcagct cttcacataa tcagcggaat aaacgcccgc tttttcttct 3444301 gtcgtcagga caccgacccg tcttccaccc tgttgatatt cttgaatgag gtgctgaatg 3444361 cgctctgggc tgccttcgca aatggcaaga ggcgctgtcg gcgcataatg tgtatatttc 3444421 atccctggag aaatcggctt ctcgttttgg tcgctgagcc ctttatccac atggatcggc 3444481 ccgatcaccg cttcaatttg ttccttcgta atgccgccag gacgcaagag aacagggatg 3444541 tcgtccgcac atgaaagcac agttgattcg accccgattc cggtagggcc tccatccaca 3444601 ataccggcta tgcggccatc caagtcgtga gccacatgct ccgcttttgt gggacttggc 3444661 ttgcctgata gattggcgct cggtgctgca atcggcagtc ccgattcgcg aatcaatgca 3444721 agggcaagcg gatgatccgg cattctaatg gcaaccgttt caagacctgc cgttacacga 3444781 ggtgaaagcg catcaggttt gcaaggcaga atgagcgtaa gtgctcccgg ccaaaaccgt 3444841 ttcatcaatg ttttcgcctt ttccggcgcc gggcccgtta aatcctcaag ctggctgata 3444901 tccgcaatgt ggacaatcag gggattatcg ctcggccgcc ctttcgcctc atatattttt 3444961 ttgacggcat ccgtattttt tgcgtttgcg cctaggccat atactgtttc tgtcggaaag 3445021 gcaacgacct cattttctcg gagcaaagcg gctgcttgtg caatttgtgg atcatttgtg 3445081 gataactcgt cagttacatc cacaaaccat cttttcgttt tcatttctga ccaaactcct 3445141 tattcacaac aataaaacga ttgttttacg cgtgtaatcc ttttgaaagt ataaaagatg 3445201 tcctgtaata aaacaagcgt tatccacaaa ttgtggacaa cgctaataaa gaagtggata 3445261 agtatgtgta taaactgcac ttatccagac gcttttttca tcaaaacggc tccttctgtt 3445321 tgccgcgatt cacagaagtg atcagaagaa aacagctcct ccggtacact ctcagctctt 3445381 tcaaaaccca tggccgtcag aaagtccgca gaggaatgct gatttgctac taggtacacg 3445441 gttttgatct gatgcttttc gcacagcacc tccatgcttt gaaaaagcgt gacgatgtgg 3445501 ccttggtgaa gcttgtccga tatgacaagt gatcgcagca gcccctggtc acagcttatt 3445561 ttttcaatac cgaggcatcc ggcaatgttt ttctcactgt cctccagcat aagaaattga 3445621 gtgaagcctt ctttcacgcc ttcatagctg gtttttgcct gttttaaaaa tgcctcgagc 3445681 acatctccgt ctttttccct tgccacccgc agttgataaa acatccgttc accccgtttt 3445741 tgcgttcttt cttccaatct atgaggcaaa tctattttta gaccagatga ttaggaaaaa 3445801 aggtcggaaa tccattcgac taaaaagaat ttcacttctg tgccgtcttc tttttcttcg 3445861 ttctcttctt ttttggcttt ttccgcttta gcggttacgt cctcaagcac tttttcagtc 3445921 tgcttttttg aggcttcttt atcttcttgt tctttgacgg cttccccgtt agaaaaatca 3445981 agaaagcaga ggggcgggaa cagcacacac caccagttgg cgccgtctcc gtttccaagc 3446041 gtaatcaaaa tcgcttcata ctcaccagcg ggatatacca tgttgccgta aagctttgtc 3446101 ggaaacgaga ttttgtcaaa atcaacggat atcgactgat tcgctccttc tttctccatt 3446161 gtttcctttg caattgcttt gatttcaggc agctttgaac gaatcacgcg acgcgcttct 3446221 tcaatagaag taatatcctt tacccaagtt gtgatttctt tattcaccgc gtctcttata 3446281 tgacgtttta attgctggtc ttgatcacta tcgctgtttg ccagtattct caaacgaatc 3446341 gcctgatcag gtatgaccac cggctgattt tccgattttt gtgccgtctc ttcttttgcc 3446401 agccctacga gcgctccgga taataaaaga aagatatata tacaaatgat tactgttttt 3446461 ttcatcggtc cccaccgttc ctctccgtgc tttgtttcta gccctattat ggacaaggag 3446521 agcctgggat aaacgtgcag ggtgaaaaaa atctagcaag ctgttaatct tatttatggt 3446581 acgatagtgt tttaggaggt ttaagatgaa atacaattat acagtgctgt tatcagcatt 3446641 cacgatgtcc gttctttatt cagtaattta tattcattca tttatcattg ccgctctcat 3446701 cacaatggca ttttattttc tgtttcctta tttgatcttc gcactgccgc ttcaaatcat 3446761 gatgaataaa aagccgaaac gtttcagccc tttgtatctg ctgtattacc ttgccgctgc 3446821 ttttattgcc aacgcgatca ttttcggcat gcttcagcct tcgggacaat ctctgtttca 3446881 aaatacagcc ttttatcttt tcgctgtatt aacagctctt atctattgga tatgggattc 3446941 tgttttactg caaaaaaagg aagcctaaga ggcttccttt tttattaaaa caaaatcgtc 3447001 agtaaataac atagaatgga aggtatcgcc gcaacaaaga aagcggccgc cattttcatg 3447061 cgagatgtac ggccttcttt ggtttctgaa tggtagtttg cccgctgatc gcttccgctt 3447121 acagccaaac ccgatgtaat gatcgcgagc cccactaaaa cgagagacgc aacgccaaaa 3447181 atcgcttcat atgaaagagc ctgcggaaaa atggtgccaa tcatgctctc aatcgcaatg 3447241 agcaggattc ctgctgtcag ggcctttttc atgtttacat cccctttgct ggtgttaaac 3447301 agcttgatcc attcactcgc cagcaagctg cttatttatt tttatgaatc agagcgcata 3447361 tggttctgtc ttttccatta atatctttca gcacttccac ttccgccccc ttaaacgcct 3447421 tgaggatcag gtctttgacc gccgctccct gtttccagcc gatttcaaaa acgacaaata 3447481 ctttatcctt cataacaagc ggaatgtctt ccataaaccg cttataaaat ttcagcccgt 3447541 ctccgccatc ggtgagtgcg tgcagcggct catgaaaacg gacaatttcc gataaatcag 3447601 ccatttcttc ctctgaaata tatggcgggt ttgagacaat gatatccgct ttttttcccg 3447661 ccttaataaa aggctcaagc agatcgccct gataaaagcg cacattcgct ccgagttttt 3447721 ctgcattggc agaggcgact tgcagcgcct ctttcgaaat atcgaccgcc gacacagaaa 3447781 agctttggtt ttcaagcgca agcgtgacgg ctattgcgcc gctccctgta ccaacgtcaa 3447841 caacttcgag cttgccgtct tcagaaaaaa cactccgata tttttcaagc aaatgaaaga 3447901 caacttcttc agtttccggc cgcgggatca gcacatcatc attcaccata aattcccgtc 3447961 cataaaaaaa ctcttttcct ataatgtatt gaaccggcac gccctcttta tgcatctcaa 3448021 cgtgacgctt aaagcgatac agttcgtctt caccaatcgg ttcctgtaag cttgcgagca 3448081 gcttgcttct ctccattccg gtatcataaa gcaataggag ctcggccgca ttttcttctc 3448141 ttcccgcttc ggttaaataa gaagaagccc atttcagggc ttcgaatatc gtcttcatct 3448201 taaccttccg actgctgaag cttgcttgcc tgatcttcaa caatcagcgc ttcaaccact 3448261 tcgtcaagtt ttccttcaag aatctgatca agcttttgaa tcgtcaaacc gattctgtga 3448321 tccgtcacac ggttttgcgg gaagttgtat gtgcggatac gttcagagcg gtcaccagat 3448381 ccgactgctg atttccgtgt ttgatcatat tcagcctggg cttcctgctg aaatttatca 3448441 tagattctgg cacggagaac cttcattgct ttttctttgt tcttaatttg agatttttca 3448501 tcctggcatg atacaacaac acctgtcggc aagtgagtca gacgaaccgc agacattgtt 3448561 gtgttaacgc tttgtccgcc cggtccgctt gaagcaaatg tatcgacacg gatatccttc 3448621 tcatggatgt cgacctctac ctcttctgcc tcaggaagac atgccactgt tgcagtggat 3448681 gtatggatgc gtccgcctga ttctgtttcc ggaacacgct gtacgcggtg ggcgccgttt 3448741 tcatatttga gtttagaata cgcgccgctt cctgtaatca taaagatgat ctctttgtag 3448801 ccgcccgttc cggttacatt cgcttccatg acctctgttt tccagccctg aagctcagca 3448861 taacgggaat acattctgta cagattgccc gcgaataaag cggcttcctc gcctcccgca 3448921 gccccgcgga tctccatgat aacgtttttg tcgtcattag gatctttcgg gatcaggagc 3448981 accttcagcc gttctgacag tgtttccgtt tccttctgaa gttcagaaat ctcttccttc 3449041 accatgtcgc gcatctcagc atccagcttc tcttcaagca tcgcttttgc atcagccagc 3449101 tgttctgacg catctctgta ttgtctatat acgtcaactg tttcttgtat atcagattgc 3449161 tcttttgaat attctcttag ctttttcgga tcgttgacta cttctggatc gctcaaaagc 3449221 tcatttaatt tctcgtatcg ttcttcaatt gattttaaac ggtctaacac ggtcttcacc 3449281 tctgttttcc tgtgcgtaac attctcatta tagtatagtg attaacccca gtcaaaagca 3449341 tttcaatccc agctggaaaa gctccctctg ctatactgga attcgaggag ggatgatgtt 3449401 gctgaaatcc atacatcata ttgcaatcat atgttcagat tacgaaaagt cgaaagcttt 3449461 ctacgtacat aagcttggtt ttcaggtgat tcaagaaacg taccgcgaag agcgcggctc 3449521 ctataagctt gatttgtcgc ttaacggctc gtatgtcatt gagctgttct cgtttcccga 3449581 tccgcccgaa cgacaaaccc ggcctgaagc cgcaggcctg cgccacctcg cctttacagt 3449641 cggcagcttg gataaagctg ttcaagagct tcatgaaaaa ggaatcgaaa cagagccaat 3449701 cagaacagat ccgctgaccg gcaagcgttt caccttcttt tttgatcctg accagcttcc 3449761 attagaactg tatgaacaat aacagttttt gaagaaaaaa aggagatacc cactttcttt 3449821 gccgaatctt ttcttgtttt gtctaacggg aagggaaccg cattctatgg tcgaatacct 3449881 agcttaaaag gaggtatggg atcatgaata caaatatggt agcaagtgaa ctcggcgtct 3449941 ccgcaaagac ggtgcagcgg tgggtgaagc agctgaatct tccggccgaa cgcaatgagc 3450001 tcggacacta ttcgttcacg gcagaagacg tgaaggttct aaaatccgtt caaaaacaaa 3450061 tctctgaagg cacggcgatt caggatattc atctgccgaa aagcgctaaa aagcgcacag 3450121 gcttccttgt ccaaaaaaca agtagcgaca cagaacgaag aatcgagcag cttgaacaaa 3450181 agctggacac ccttttacag caaaggcagg acgaaagcga attgatggca aggatgtcgg 3450241 aactggaacg ccagctgaaa caaaaagccg atgaaggtgt atcttaccag ctgcttcagc 3450301 accgcagaga aatcgatgat attcttgcag atctgcaatc actgacctca caaatgaaag 3450361 aattcaccgc tcattcgatc cccgagactg ctgctgcttc tgaaaaaacc aaaacaagaa 3450421 aaaaaccgct gctgtcactg ttcaaatttc aaacctaaag caaaaagctc ccttaaaggg 3450481 agcttttttt gttacgcagt aagcgcgata atgattggaa gtgaaatcaa tgacagaatc 3450541 gcactgacca caaacgcagt tgcagtttct tcttcttgtt tctcgaaacg agtcgcaatc 3450601 atggctgcaa cggcagaacc agggaatgca acaagaagga ttgcttttgt tgtttggtca 3450661 gctggaagtc cgatagcaag agcaatcagg aacattaacg caggctgaac cgcaactttt 3450721 agtaacgcaa taccgatagc cggcatactg agtttaattt tacgaatacc aacggtaaca 3450781 ccaacagcga agagagcaac accagatgtt gtgcttccaa gctgatcaag cattttaaca 3450841 cccagctcag gaagagtgaa attgaaaacc agcaccaaga tcatactgat taacggagca 3450901 gctgcaagcg gctcacaaag accatgcagg attgattttc ctgtcatctt ccagaagctg 3450961 tcgccactct cttcgttttt cttagaagac tcaccaacag tagcgataat gatcgcgagc 3451021 ggatcaagaa tcgcgttaac cacgatacct gtgaccgcga tcggaatcgc aacttcattc 3451081 gctccgaata agcttcccaa taccgggata cccataaatg cgaatgtcgg ctgtgcagag 3451141 ttcaaagaaa atacagatga gttcgttaaa tcatacttga atataaatct gcaaaccaaa 3451201 agaatgatga tatagaaacc aacaatccca ataattaaag aaatcattaa aggtacttgt 3451261 gataaaaatt cacttctgga agttgtcaaa ataccagcga taaagtgagc tggaagtgcg 3451321 tatttcgtta ctaacgtact tacccctttt gccgacttgg catcataact tccaaaatgt 3451381 cctgcaaacc aacccagcac gataacaaag aagatcggcg ccaggaggat taagatatct 3451441 aagatgctca aaatattctc ctccaaatcc tatgtccgta tactttagct ttacaaaaag 3451501 ctttccctcg gacagaaaaa tttactcgct aattatttcg cgatgacttt tttgtattca 3451561 ggtgtccaca ttgcatcaag taccgcttgt ttcacatctt caggctgacg atttgccacg 3451621 ccgtctttaa ttgctgcttc agcaacggca atcgcaactt ggatagaaac ctcttgaagc 3451681 ttatcaatgc ttggaagcaa tcctgctcca ggtgtttcaa gatcaaccat ttcagcaatc 3451741 gcatcagcag ttgcagcaaa catagcaggt gtaatgatac gcgcttcagc tacaattgaa 3451801 ccaagtccaa gaccagggaa cgcgaatgcg ttgttagatt gtccgatttc ataagaaaca 3451861 ccgttgtatt ctacattgtc aaatgggctt cctgttgcaa taagcacttt tccgtcagtc 3451921 catttgaaca gatcttcagg aacagcttca gcaaggtgag tcgggttaga catcggcatg 3451981 ataaccggac ggtctacgtg agatgccatt tcttttacaa tttcctctgt gaatgcacct 3452041 gaaacccctg aagtaccaat caagattgtt ggtttcgctt gacgaacaac ttcatcgaat 3452101 ggaatttgac ctttttcatc gcgcttccag tctttcactt catccgcatt gcgaaggtaa 3452161 ggtttttgga aatcaaggat gccttcgatg tcttcagtca gcaagcctct gtaatcaagt 3452221 gtgtagaaac gtttgttagc ttcttcttca gataatccgg ctagcaccat tgtgtcacgg 3452281 atttggtcag caataccgat accagcagaa ccagcaccga agataacaac acgctgatct 3452341 ttaatagaag cgccggtttt cttcatagcg gcaagcacac ctgcaagtgt aatcgcgcca 3452401 gtaccttgaa tatcatcatt aaatgtcagg atttcatgat tgtatttttt catgatgttg 3452461 cgtgcatttt tgttgccaag gtcttcccag tgaagaagcg ctttagggaa gaatttcaat 3452521 gcagctttta cataagcgtc aatgaaagct tcgtagcgtt caccttgaac acgttcatgc 3452581 ttgttaccaa tatataaagg atcgtttaga agtttttcgt tgttcgtacc gacatcaagc 3452641 acaaccggga taacacggct agggtcaata ccagctgcag cagtgtagac agccaattta 3452701 ccgattgcaa tattaatacc gcctacaccc cagtcaccga taccgagaat gctttcggag 3452761 tcagtagcaa cgataagatc aatatcgcct gctgtcgcat gaaggttttc aaacgctttt 3452821 tcaataccgt caatgttatc gattgacaag tagattcctt gaggtcttct atattcatgg 3452881 ctgtattcct gaatcgcttc accaactgtt ggcgtgtaca caacaggaag catttcgcga 3452941 agatggtttt tcagcaattt atagaaaaga acttcgttac ggtttgcaag atcacttaag 3453001 taaacatttt gacgaaggcg gtcaggctgc gcttggaatt gctcgtacgc gcgttgtgct 3453061 tgttgatcaa gagaaagtac agttggcggc agaagccctt ctaagccgag ttcttgtctt 3453121 tcttctagtg aaaaagcaac gcctttattt aaagtaggaa tagataaaac ttcttttcct 3453181 ctaagagttg tttctaagtg gccttctttc gtttttttta tgttattcaa gcaaatctcc 3453241 ttctttcttg aaatagttaa ccaagttaag taataaccca tctaaaatat gaccgatcat 3453301 gatctttatg cgactttgtg acaattattc gaacaatgtc tcaaaactat ttacattacg 3453361 taagctattg tatgcctgtc aaaatcaaaa ttcaagagaa gaaaattact taatttttta 3453421 atatacttat ttaaattttt taattgaata ttatcagaat ataaaaaaaa caccggtgtt 3453481 tttagccggt gcattctatc tttataccca tgttttggac tattttttag atttacctgg 3453541 gacttcgtga tgatgtctgc atcttgcttc atatgattca gctgcaccaa ccaaaatgac 3453601 cggatcatcg taagaagcag gtttgccgtc aatgaggcgc tgtgttctgc tcgccggtga 3453661 tccgcaaaca gaacagacgg cttgcagctt tgtcacactt tccgcaatcg ccatgatatt 3453721 cgggacgaca ccgaacggct ctcccctaaa atccatatca aggcctgctg ctatcacacg 3453781 gtagccttta tcggcaagag atgataaaac ctcaacaatt tcctgatcaa aaaactgcac 3453841 ttcatcaacc gcaaccacat ctgtactttc actgatgtga tcccaaatgt ccgcagcaga 3453901 cgaaatggca tagctcgtca tcgatgttcc attatgggag acaacagcag cttcgctgta 3453961 tcggttatca attacaggct taaataccct gacttcctgc ttggcataag ttgctctctt 3454021 cactcttctg atcagctctt cagatttccc cgagaacatg ctgccgcaaa tcagctcaag 3454081 ccacccgctt tgtttcatta tgtacatagg cttcgctccc ctctctctgc cagctgtgtt 3454141 ttagacaata taaaaaacag gcaagactgc tgcttgcctg ttgagaaatc tattattact 3454201 taagaccgta ttttttgtta aagcgatcaa cacgaccatc agcagaagcg aatttttgac 3454261 ggccagtgta gaatgggtgg cattcagagc aaatctcaac gcgtacctct tcttttactg 3454321 agcctgtttc aaattcattt ccgcaagcgc atttaactgt tgcttttttg aaattaggat 3454381 gaattcctgc tttcattgta tccatctcct tccgccctga atcccgtgtg gaaacagagt 3454441 tattatttcg gagcattgtc cgaaacgcat atgagaaaat tatatcagtg atttacttct 3454501 tttgcaaata caatttacct tcttgcagat gatagatttg cctgtttcca ttcttgattg 3454561 agaatatcga aaaattcctg gtttgttttg gtttttttca tttttctcat gaacttttct 3454621 gcgaaatcag gtgaatcaga catcgttttg cggatagacc ataaacgatc aagatgctct 3454681 ttaggcacaa gcagctcttc tttgcgcgtt cctgaacggc ggatatcgat ggcagggaag 3454741 atgcggcgct cggcaagaga gcggtcaaga tggagctcca tgttgcctgt tcccttgaat 3454801 tcttcataaa tgacatcatc catacgtgaa cctgtatcga ccagagccgt agcaaggatg 3454861 gttaagctgc cgccctcttc gatatttctc gcagccccaa agaagcgttt cggacggtgg 3454921 aacgccgctg ggtcaatccc cccggaaagc gttcttccac ttggcggaat cactaagttg 3454981 taggcgcggg caagacgtgt gatgctgtcc atcaggataa tgacgtcttt tttgtgttcc 3455041 acgagacgca tcgcacgttc aagcacaagc tcggccactt tgatatggtt ttccggcact 3455101 tcatcaaacg ttgagctgac gacatcccca gctacagagc gctcgatatc ggttacttcc 3455161 tcaggtcttt cgtcaattaa aagcacgatc agctctgctt caggctggtt cgctgtaatg 3455221 ctgttggcaa tttccttcag caacatcgtt tttccggctt tcggcggcgc aacaatcaat 3455281 ccgcgctgcc caaatccaac cggcgccatc atgtccataa ttcttgtaga caagaagttc 3455341 ggctttgttt caagcaccat ttgacgatcc ggataaagtg gcgtaagagc cgggaaatgc 3455401 acacgctctt ttgcagattc gggatcatcc ccatttactg cttcaacgtg caaaagtcca 3455461 tagtaacgct cattttcttt tggcgggcga accttgccag atactttgtc tccgttccgc 3455521 aaatcgaaac ggcggatttg tgaagctgag atgtaaatgt cttctgagct tggagagtag 3455581 ttgatcggtc tcaggaatcc gaaaccttca gactggatga tctcgagaac gccttccata 3455641 aacagcagat cttcctgttc tgcattcgct ttcagaatgg cgaaaatgag ttcttttttt 3455701 gtcagtttgc tgtaatagga gattttataa tgtcttgcaa gttcataaag ctctttcaat 3455761 ttcatatttt ccaaagagga aatagatacg tctttcataa aaacaccacg cttttcatag 3455821 tcaatatctt actctgaaca tgtcatctgc tgcttttgca caacatccgc caaagcacat 3455881 tcttttttta acataaagga acttctatcg gtaacacttc cacccatgat cggcgctttt 3455941 gttaaaagga ttgtcttaat gagttttgaa ggaagcgagg acaaaaacat gagaagatca 3456001 atacttatat cgtctgtatg cggtagaaat tgaaactttc ctagtgctta aaagaaggta 3456061 ttacgcagta aaattcgcag cactctttat ttttacctta tttcaaaaaa ttattcaact 3456121 gaaataaggt tttgacacgg aattgataga gttgacgctt ttctgcaaaa gttaaagcgg 3456181 gctcacaccc gctttttctg tttgttatgg acggattaca agatttggtt tctttttcaa 3456241 gctgtgtctg ccgtcaacga aacgaacagt gcccgatttt gcacggataa ctaagctttc 3456301 agttgtaccg acagagcctt tgaattgaac tccttttaac agctcgccgt cagtaacccc 3456361 tgtagctgca aaaatcgcgt catcaccctt cacaaggtct tccatgcgaa gcactttgct 3456421 taaatcaagg cccattttgt gacagcgagt gatttcttct tcgctttgcg gaagaagttt 3456481 accaatgatt tctccgccga gtgcttttag cgcaacagcg gaaagcacac cctcaggagc 3456541 gccgcctgat ccgaacagga tatcaacgcc cgtgtggtcg aaagccgtgt tgatggcgcc 3456601 tgcgacatcg ccgtcattga tcaatttgat tctggcgccg gcctcacgaa gctcggaaat 3456661 gatttttgcg tgtctttcac ggtttaaaat tgtggcaacg acgtcctcaa cgtccttgtt 3456721 tttcgctttt gccaccgctt taaggttgtc aatgacaggt gcttcgatgt caatgcagcc 3456781 caccgcttcc ggaccgactg cgattttttg catatacatg tcaggagcat tcagaagcgt 3456841 gccatggtct gcgaccgcga taaccgtcag cgcgttccag ccgccgcttg ctaagatgtt 3456901 tgtgccttca agagggtcaa ctgcgacatc aacgcgaggg ccgtacccgt ttccgagttt 3456961 ttccccgata tacagcattg gcgcttcgtc catttcccct tcaccgatta caacggtccc 3457021 tttcatcggc actgtatcaa aaacgtctct cattgcactt gttgccgctt catcagcctc 3457081 atcttttttt ccccggccca tccatcttgc tgatgccaat gccgcagctt ctgtcacacg 3457141 taccaattcc attgataaac ttctttccat ttcaacacga tctcctctca caagaaacca 3457201 ttatgaattt tgaagctgtt ctatttcttc gtcagtcatt ctttcacgcc aaattgtcgc 3457261 tccaagcccc tcaagcttct tctcaaggct gctgtatcct cggtcaatat gctccagtcc 3457321 cgtaatttcc gtgacgccat cagccatcag tccggctacc accaagcagg ctccggcacg 3457381 cagatcactc gccttcactt ttgcgccttg aagctcgaca ggacctgtga tgatggcaga 3457441 tctgccttct actttcatat tggcacccat tcgtctcagc tcatcaatgt gcttgaatct 3457501 tgccgagtag atggtgtctg tgacgacact cgtccctttc gcccttgtca ggagcgccgt 3457561 catcggctgc tgtaaatcag tcggaaaccc cgggtatacg agggttttga cgtcaaccgg 3457621 ctttaagttc ttctgcccgc cgacaatgag gagctggtcg tcgcttgttt cgatatgata 3457681 gcccatttct ctcagctttg ccgttaacga ctcaagatga gtagggatga cgttatcgat 3457741 aatgacttcc ttgcccattg cagcccctgc aatcataaat gtcccggctt caattctgtc 3457801 cggaatgatc gtatgcttgc agccgtgcag ttccttcacg ccgtcgattc gaatcacatt 3457861 ggtgcccgca cctttgattt tggcgcccat gctggtaagc aatgtcgcga cgtcaatgat 3457921 ctcaggctcc ttggcagcgt tttcgatgat cgttttccct tctgccaaaa cagcggcgag 3457981 cataatgtta atcgttgccc caacgcttac gacatctaaa taaatccgtg cgcctctcag 3458041 cctttcagct cgcaaataaa tggcgccttg ttcattggtt acttcagctc cgagtgcttc 3458101 aaagcctttg atatgctgat caatcggacg gggccctaag tgacagccgc caggcaatcc 3458161 aatgaccgcc tgcttgaagc ggccgagcat cgcccccatt aaataatatg acgcgcgaag 3458221 cttttttact ttcccgttag gaagcggcat gctgatcatc gacgtagggt caacaaccat 3458281 ttccccattc tcaaaatgca cgttgccgcc gatttccttt aacaggtcac gcagcgtttc 3458341 aatatctgaa atctctggaa gcccttcaat tgtcacctcg gaatttgcca aaatggttgc 3458401 aggtattaac gcaacagcgc tgtttttagc gccgctgata tgtactgtac cgtttaacga 3458461 gtcaccgccg gcaatattca acttttccat gatagtctcc ttccataaga agatagctgc 3458521 ggagctaaat aaaatgtcat tttattctgt ctctgcaaat aaagctcatg tccaaaatct 3458581 agccaattcg aagagaaaga atacaacaca ttgtaaaata tcaggaagaa aatagcgaag 3458641 ctttgggggg tacaggtttc aaaagatgca cagagacccg ccggctcgag agacatcgtc 3458701 gtcatccggc aaaagcagta cgcataccct tcattccgat atcagcttct gcagcccaat 3458761 gattccttct ctgtaaagcg gcgtcagcat ctgaagatcc gctgtatcag gtcggtgaaa 3458821 tacaaaggcc gcggcaaaca ggcataaagc tgtttgccgc ccctttcatt atttgttcca 3458881 gtctgccagg aattgttcga ttcctttgtc tgttaacggg tgtttagtga gcgcatgaat 3458941 gactttcagc ggcattgtgc cgatatgagc ccctctaaga gcagcttctg tcacgtgctg 3459001 cggatggcgg attgacgctg caatgatttg cgtgtcaagg ccgtgaatgt caaaaatctg 3459061 tttaacttct gaaatcaggt caagcccgtt gtggccgatg tcatctaaac gtcccaggaa 3459121 tggagataca tatgttgccc ccgctctggc agcaagaagc gcctggttgg cattgaagat 3459181 caatgtaacg tttgttttga tgcctaagtc agtaagtgct cttaccgctt ttaaaccgtc 3459241 agacgtcatt gggattttca ccgtaatgtt cggagcgatc ttcgccagtt cttttccttc 3459301 ctcgatcatt tcctcagctt tcaaagaaat aacctctgcg cttacagacc ctttcacgac 3459361 gtctgtgatc tcgcgaagac ggtcgtggaa tgatacgtta gcttcctttg ctactaaact 3459421 aggattcgtc gttacaccgg cgagaattcc taattcattc gcttctctaa tttcatcgat 3459481 attggctgta tcaacaaaga ataacatttt caaaaagcct ccctgattaa gaaattttct 3459541 gaactgcgaa tatgattgcg ctttctaaag atagacggaa aaccgcctgt caagctgtca 3459601 ggcggctata aaaagttcca attgaattaa gcttggtttg aagaaccaaa ttcacgcatt 3459661 ttaccgataa ctgtttcttt gatcgcttca cgagctggtc caaggtattt acgtggatcg 3459721 tactcgtcag gcttagctgc caatgtttcg cgaacagctt ttgcagaaga aatttggttt 3459781 tcagtattca cgttgatttt agctgtacca agtgaaattg attttttgat gtcagcagtc 3459841 ggaattccag taccgccgtg aagaactagc ggaaggccag ttgattttcc gatctcttcc 3459901 atttctttga agccaaggtt tggctcacct ttgtaagggc cgtgaacaga acctaatgca 3459961 ggtgcaaggc agtcgatgcc agtgcgctca acaagctctt ggcactcttt aggatcagcg 3460021 tagattacgc cttcagcgat aacgtcatct tcttgtccgc ctactgttcc aagctcagct 3460081 tctacagata ctccgtggaa atgagcaagc tcaacaactt tagcagttgt tgctacgttt 3460141 tcttcaaatg gatggtgaga agcgtcgatc attacagatg tgaaacctgc atgaatcgct 3460201 ttcgcacaag attcaaagct tgaaccgtgg tctaagtgaa tcgcaacagg aactgtcact 3460261 ttgtactctt ccataagtgc ttttaccata gcaacgactg ttttgaagcc gcccatgtag 3460321 cgtcccgcac cttcggaaac accaaggatc actggagatt tttcttcttc agctgcttgt 3460381 aaaatcgctt gagtaaactc aaggttgttt aagttaaatt gtcctacagc gtaccctttt 3460441 tctttagctg tattcaacat ttccgtcata gaaactaaag gcatgtcgaa tgtcctcctt 3460501 atgtagcctg attgtcttct agcgaaaaaa gctttccacc ctagcatgac ccatatattg 3460561 ctgtcatatg taaatactca gatcgctttt tctccataac taggatacca acttttcgac 3460621 aaatcggcaa cataatgaca tgattcattt gtttcttctt tttgtcagtt agacttcagg 3460681 ggcagatatt ttttgacggc gtctctgatt tcgtcgatgt caaacggctt ggcaaagtgc 3460741 gtcagagcgc ccaattcctt cgattcctgg atcatgtcga gctctccgta tgccgtcatg 3460801 ataatgaccc ggatgttttc gtcaatgacc ttcatccgtt ttaagatttc gattccgtcc 3460861 atgccgggaa ttttcatgtc caacagcaca aggtcgggcc gttcttttgt cacaatgtca 3460921 agcgcctgca ggccgttcgc agcctgaaac gtctggtagc cttctttatt gaacacttca 3460981 tttagcaaaa tacgaatgcc gtattgatca tcaacgatta aaattttttc attcatcatt 3461041 ttacacccca atattatgat tttcgtcaaa agtaagcagt attgtatgta ttctgtttga 3461101 ttttcctatt tcctttaatt ataatagtct actttacgac attttctgag cattttctct 3461161 tttgttgtat actgatattg tacgttataa aggaggattc acttatgttg aaaatattca 3461221 cgacgcagtt aacaggtatt ttttcccgca ttcaggataa ggaatctgac gcgattgaag 3461281 atggggcgcg gctgcttgct caagcggtga tcagcgggca ttccatttat ttatacggag 3461341 cgaatgagct tcagggcgtc ttttatgagg ccaccgaaag caaagaaccc ttcccatctg 3461401 tcaaagcctt tccagaaaac gctgaggaag tgacagaaag cgacagggtg ctgatgtttt 3461461 gctcagggac gggcacagcc gaagaacagg agctcgcaaa agagctttat gaaaaaggtg 3461521 cgggagtcgt atgcgtatcg cccgcagcca aagacagtgc gggaatagaa cagtattgtg 3461581 atgtgcatat tgattctaaa ttaaaaatgc cgcttgttcc cgatgaagac ggcacccgtt 3461641 acgggtttcc ctctttaatg acagcactgt atgtctatca cgctttatcg tttacactaa 3461701 aagaaattct gcaagagtat gcataatatc ttattgtaca tgctggaact tgccggaaac 3461761 aaataaaaaa gacttgcccg cttttgacaa acggcaagtc ttttttatta cttctgattt 3461821 gcagcttcga cagacgctcc gataaagcct ttgaatagag gctgaggtct tgtcggtctt 3461881 gacttgaact ctgggtggaa ctgagaagcc acgaaccaag ggtggtcttt cagctcgatg 3461941 atttcaacaa ggcgtccatc agggcttgtg cctgagaata cgaagccttg ctcttccatt 3462001 tgctgtctga attcattgtt aaactcatag cggtggcggt ggcgctcgta caccacttca 3462061 tcctgataca cttcaaaggc tttcgtgcct tcttcaagct tacaagggta aaggccgaga 3462121 cgaagcgttc ccccaagatc ctcaacatcc ttttgttcag gaagaagatc aatgatcggg 3462181 tattgagttg acggatcaat ttccgctgag tgagcgcctt ttaagcccaa tacgtttcgt 3462241 gcgtattcaa tagacgccac ctgcatgccc aagcaaatgc ccaagaacgg aatgttgttt 3462301 tcgcgcgcgt attttgtcgc gacgattttc ccttcaacac cgcggtctcc gaatccgccc 3462361 ggcacaatga tgccgtctgt tccgcttgtg agttctgcga tattgttttc tgtcacttct 3462421 tccgcgttga tccacttcac ttttacatct gtgtcaaacg catagcccgc atggcggaga 3462481 gactcgacaa cagaaatgta tgcgtcagga agctcaacgt atttgccgac aaggccgatt 3462541 gtaatcgttt gagacaggtt gctgactttg ttaacaagct ctttccactc ggacatttcc 3462601 gcttctttgc atgccaattt catgtgctcg caaacaagct tatcaagccc ttgtttttga 3462661 agctccagcg gaatggagta aaggttgtcc gcatcttcac attcaataac cgcttttgta 3462721 tcgatgtcgc agaaaagcgc gattttatct ttcatatctt gagaaatcgg catttctgta 3462781 cgaacgacga tgatgtttgg ctgaatgccc aagctgcgca attcttttac gctgtgctgt 3462841 gtcggttttg tttttaattc gccagcagct ttaatgtaag gcacgagcgt acagtggatg 3462901 tacattacgt tttcacggcc gatgtcgctc ttcatttggc ggatcgcttc aaggaatggc 3462961 agtgattcga tgtctccgac agtaccgccg atttctgtaa tgacaacatc tgcgtttgtc 3463021 tctttccctg cgcggtaaac acggtctttc aattcgtttg tgatgtgcgg aatgacctgt 3463081 acggttcctc caaggtaatc tccgcggcgt tcttttttaa gaactgttga atagatttta 3463141 cctgttgtca cgttgctgaa tttattcagg ttaatgtcga taaaacgctc atagtgacca 3463201 aggtccaagt ctgtttcagc gccgtcatcc gttacgaata cttcaccgtg ctggtacggg 3463261 ctcattgttc ccgggtcaac gttgatgtat ggatcgaatt tttgaatcgt cacgttcagt 3463321 ccgcggtttt tcagcaaacg ccctaatgaa gctgctacaa taccctttcc aagtgaggat 3463381 acaactcccc cggttacaaa aatatatttc gtcatttcgt ttgctcctct cttcgctctt 3463441 agctacattt ttaaaatgta ctattttata aaaaatcatt tagcctttta aatgatttat 3463501 aagaaaaatg aggggtgaaa ataagaaagc tccctttcaa tttcttgaaa gggagcataa 3463561 cgtactatgt tctctcttcg tttttgaaga gcccaaaata catactacat agttcgacta 3463621 tgaaagtcaa gatcgttttg aagatgaaat ctgatactat ttaatttcct cttcttcatc 3463681 atcatagtct tcatcatctt catcaataat atcttcttcg atctcaagat catcgtcgtc 3463741 ttcatcaaga tcttcttcgt caaaatcgtc ggcttcaaga tcgagttctt cctcaacttc 3463801 atccaaatca aggtcgtctt cgtcgatctc ttcaaactcg tcaagatcaa gatcttcttc 3463861 gactgctttc ttcgcttttt tctttttcgc cttgactgtc ggctgagttt cttcatcaag 3463921 ctgatcataa ggataccagc tgcgaagccc ccacgtctgg tcagaaagcg ccaggaagcg 3463981 gccgtcaatg tttaaatctg tataaaattg agcaatgcgg tctccaagct cttctttttt 3464041 cacgccgagc aaagatgcga tttcatttaa aagctcctga aaaggaactg gttttttatg 3464101 ttcttcaaat aattcgtgag cgatttcaac taaagccatt tcctttagct cttcctgtga 3464161 atattgtttg atacccaagg tcggacactc cctttctatt acttatatgt atctgtttta 3464221 tcaataatga aagcgatttt gtatcgttct tatacaaacc atacctctca ttataaacaa 3464281 aataaaacag aatatgctac ccttaacagc gttaatttaa ataattttac aagagtgatc 3464341 cgactgagag atgttttccg ttaatccgcg agcattctgg agatgaccag tctttgaatt 3464401 tcttgagtgc cttcatagat ttgcgtgatt tttgcatcac gcatatagcg ttctaccgga 3464461 taatcttttg tatagccgta gccgccgaaa atctgcacgg cttcggtcgt taccttcatc 3464521 gccgtatccc cagccatcag tttggacatg gcggaagctt ttccatatgg aaggcccgat 3464581 gattctaacc atgcagcctg ataggtcagt agccttgaag cttctatcat tgtcgccata 3464641 tccgcgagtt taaaagcgat gccctgctgc tcggcgatcg attttccgaa ttgctttcgc 3464701 tcttttgcat attgaagcgc cgcatcaagc gctccttggg cgatgcctac agcttgtgca 3464761 gctatgccgt ttctgcctcc gtcaagcgtc ttcatcgcga ttttgaagcc ttctccttct 3464821 tctccgagac gctttgatgc gggcactaca caatcttcga acatgatttc cgttgtcggt 3464881 gaagaacgga tgcccagctt cttttctttc ttgcctgtaa aaaatccttc aaaatccttt 3464941 tctactataa aagcggtaac gccttttttc tttttctcgg gatcggtgac ggcaaaaaca 3465001 atgtaaatat cagcaacgcc gccgtttgtg ataaacactt tggaaccatt taacacatag 3465061 tcatcgccga ttcgttcagc agttgttttc atgctgccgg cgtcagagcc agaccctgct 3465121 tcggtcaaag cgaatgcgcc gattttctct ccgagagcca gctgtgttaa gtactctgtc 3465181 ttctgttcct ctgtcccaaa ggcaaacagc ggccagctgc aaagagagat atgggcggaa 3465241 agcgtcacac cggtggaggc gcacactttt gacagctctt ccaccgcgat gacgtaggct 3465301 aaatagtcac ttccaattcc gccgtaatct tcaggccatg gaattcccgt caggcccaga 3465361 tttgccattt cccgaaacag ctcgcgatcg aagcgttctt gttcgtcccg ttcagccgct 3465421 gtcggggcca cctcatgctt cgcaaaatcg cgcaccaatt ttcgtatcat ctcatgttct 3465481 tctgataatg aaaaattcat tgcttctccc ccattttcag atcagcgcct aaaacggatt 3465541 gagccagaag ctcgacgacg tcgtacgttt tgacttggtc ttcggcttcc ttcgcctttg 3465601 tgccgtcccc aagcatcgtg agacaatacg gacagccaga actgatcacc gatgggttga 3465661 ctgcgagcgc ttgctctgtc ctggcgacgt taatcctgtt gcctgtttct tcctccatcc 3465721 acattaatcc cccgccggct ccgcagcaca tgccggtttc ccggcttctc tccatttcaa 3465781 caagctgcac gcccggaatg gctttcaaaa tctctctcgg cggatcatag acttcattgt 3465841 accggcccaa atagcacgaa tcatggaagg taatcgtctc atgaagcggg tgctgcggtc 3465901 ttaattttcc gtttttcaca agctcggcca gcacttctgt atgatgataa acctcgcctt 3465961 caaatccgaa atccggatat tcgtttttaa ataaattgta tgcatgggga tcgatcgtaa 3466021 cgattttttt gacatcattt ttttcaaatt cagaaatatt cttctcagcc agctcttgga 3466081 acaaaaattc atttccgagg cggcgcggcg tgtctcctga atttttttct ttattgccga 3466141 gaatcgcgaa ggacacgccc gcgtgattga gcagcttggc aaaggaaatt gcgattttct 3466201 ggcttctgtt gtcgtaagac cccatggagc ctacccagaa aaggtactca aattcttttc 3466261 cttctttttt catttctttt acagtcggaa tctcagcatc cggcgcctcg tcacgccaat 3466321 tttcacgttc cttgcggttg agtccccacg gattcccttg ccgctcaata cttgtcattg 3466381 cgcgctgggc gtcactgtcc atttttcctt ctgtcagtac gaggtagcgg cggaggtcga 3466441 tgattttatc cacgtgctca ttcatgaccg ggcattgatc ctcacagttc cggcaagtgg 3466501 tgcatgccca aatttcttcc tctgtgatga cgtcgccgat caagcttgga ttgtaatcaa 3466561 gcgccgctgc ggcttcctgc gatccgctgc ccgctgacgc cgcagccagc tgattgcctc 3466621 tcgtatgccg aaacgctgct gcgggcaccc atggggagcg cgaggtgacg gcagcgcctt 3466681 tttccgtgag atggtctctg agacgcaaaa tcaagtccat cggagaaagc atttttccgg 3466741 tgcctgttgc aggacacata ttggtacagc ggccgcactc gacacacgcg tatagatcaa 3466801 gcagctgaga ctgtctgaaa tcctcaattt ttcccgctcc gtagctttct ttcgtttcgt 3466861 cggtaaaatc aattttttca agttttccgg cagattccat tcgattgaaa aagacgtttg 3466921 ccgggccggc gattaaatgg gcatgctttg actgaggcac gtacactaaa aagctaagca 3466981 agaataggag atggatccac catgcgatat agaaaatcac cgccgcgcct gttttcccga 3467041 caccgctaag cataaacgca atacctgagg caattggctc gctccaagaa agcccatgct 3467101 catgccaaat cagattcatc ccgttcccaa gcagaacggt cagcattaat cctccgataa 3467161 aaatgagaac gagtccggct ttgaaaccgc gtttcagcct cacgagcttt tcgatataac 3467221 gtctgtagaa tgcccaccca acagcaatta aaatgagaaa cgtaacaatt tcctgaaaaa 3467281 aggtgaaggc gggatagacc gggccaagcg acagattccg gccgggagcc agtcctttga 3467341 tgataaagtc aattgctccg aactgaacca atataaatcc gtagaaaaac atgacgtgaa 3467401 tgattccgct tttcttgtcc ttgagcagtt ttttctgtcc gaatacattc acccatatgg 3467461 cgtgaagccg ttccttgaac cgttgatcaa attgttcttt ctggccgagc ttgatgtagg 3467521 ccagtctcgt tttgaccaag taaacaaaca aatagacagc gtaagcggtt acaatcagaa 3467581 ataataatgc atttgcgatg agaaagccgc tcattccaat tccccctttt tactgataaa 3467641 gaccgcgatc ccctaccccc gaatctgtat aagattatct ttatgataaa taatgaatga 3467701 gtgttcagtc aataattaaa ttcctgctgt tcgggcacac tacctttact acggaaagga 3467761 gtgccggtat gaaggtattt atcgtgatta tgatcattgt cgttattttc tttgccttga 3467821 ttctgcttga tatcttcatg ggccgtgccg gatacagaaa aaaggcgtac gagcctgttt 3467881 tttcaaaaaa gaagagtgac atcgaattga tccactgcgg cgctgatctc gttgagcgga 3467941 tgatgaatga tattcgccag gccgcctctt ctgttcacat gatgtttttt attatgaaaa 3468001 atgatgaggt cagccacaat atgtatacct tgctgaaaac aaaagcccaa gctggcgtat 3468061 ccgtttattt gcttctggat tgggcgggct gccgggcaat taaaaaaacg gcgcttcaga 3468121 cgatgaaaaa tgccggcgtc catgtccatg tgatgaatcg tccccgtttt ccttttttct 3468181 tttttcacat gcaaaaacgg aatcaccgga agattacggt gatagacgga aaaatcggtt 3468241 atatcggcgg gtttaatatc gccgaagaat atcttggaaa gaaggcgaag ttcggcaatt 3468301 gggaggatta tcatctgcgc atgatcggag aaggcgtaca tgatcttcaa acgctttttg 3468361 cttctgatct aaaacgaaat accggaatcg aactgggttc ggatgtttgg ccaaagcttc 3468421 agcaagggac tatttctcac aagatctatg cgaccgacgg ttattccctt gaaaacatat 3468481 acttggccaa cattgcccaa gcgaagaatc gccttacggt ttgcacgcct tattacattc 3468541 catcaaaacc gcttcaagag gcccttatta acgcaagaaa aaacggcgta tccgtgagaa 3468601 tcattgtacc gatgaaatca gaccatccgc tggtacgaga agcggctttt acgtattatt 3468661 cggagctctt ggatgccggc tgtcttattt atcgttatta tcaagggttt tatcatgtaa 3468721 aagccctcat catagacgac catctcagca ttatcggaac agccaacttc gataaacgga 3468781 gcctgttctt aaatgaagag gtgaatgttg aaattgatga cgaagcgttt acaagtgaag 3468841 tctatgccac aattgaggag gatatgaaaa agtcggagct gctgacgatg gaggatttca 3468901 gcaagcgcac attcaggcag cgcccggcgg aatggctcgg cagggcatta tcttatttct 3468961 tataaaggag agttcctatg attttcagat tcgggttcgt ttcaaatgcg atgagccttt 3469021 gggatgcgtc tcccgctaaa acattgacat tcgcgcgtta ttcaaagctt tcaaagactg 3469081 aaagaaaaga agcgcttctg actgtgacaa aagccaattt gcgcaatacg atgagaaccc 3469141 ttcactatat catcggccac ggcattcctt tgtaccgttt ttccagttcg attgtgccgc 3469201 tggctacgca tcccgacgtg atgtgggatt ttgtaacacc gtttcaaaaa gagtttcggg 3469261 agattggaga gcttgttaaa acccatcaac tgcgaacaag ctttcatcca aatcaattca 3469321 ctctgtttac gagcccgaag gaatccgtca caaaaaatgc ggtaacagat atggcgtatc 3469381 actaccgcat gcttgaggcc atgggcattg ctgatcgctc cgttatcaac attcatattg 3469441 gcggcgctta cggaaataaa gacaccgcca ctgcacaatt tcatcaaaat ataaaacagc 3469501 tgccgcagga gatcaaagag cggatgacac ttgaaaatga tgataaaaca tatacaacgg 3469561 aagaaacgct tcaggtctgt gagcaggagg atgttccgtt tgtctttgac tttcatcatt 3469621 tttacgccaa tccagacgat cacgccgacc tgaatgtagc actgccccgc atgatcaaaa 3469681 cgtgggagcg gatcggcctt cagccaaagg ttcacttgtc ttccccaaaa tcggagcaag 3469741 cgatacgcag ccacgccgat tatgttgacg ccaacttttt gctgccactg ttggaacgct 3469801 ttaggcaatg gggaactaat attgatttca tgattgaagc aaagcagaaa gacaaggcgc 3469861 ttctccgctt gatggatgaa ttaagctcca tccgcggtgt caaacgcatc gggggcggtg 3469921 cgctgcaatg gaagtcataa atgtgcaaaa ataggtttac gacttgtcag ctttgggaac 3469981 ttaggctata taagacaaca atcgatggag gagaaagatc atgaaaaata tcaagtctct 3470041 gaaagtagcc gcacaggcct ttactttaag aaatttgatt catctttata aaatgtgcca 3470101 ttccggaagc cacgaggttt atatttattc aaagaaaacg atgtgcaaaa tcaaaagctt 3470161 aattgagctt gaaacgttcc gcatggctca taatgaaaag gaatatctga tcgtagttga 3470221 aggaacaaaa gcatcacagc tcattgaaaa attccaaaat ctcatcgagc ctgctgagag 3470281 agaagcgctc taacttacat acaaaaaagg atagacatct gtctatcctt tttcttatgc 3470341 tcttacataa tggagctgaa ccgcttgtcc aaattgtttt gtccctttta accgcagttt 3470401 tgtttcattt gttagttcgt gaaacagcgg gatgccgctt cctaaaacga cgggaataac 3470461 agtgatgatg aattcgtcga tggcatcttc tttcataaag tcattcacaa gctctgcccc 3470521 gccagctatc cagatgtttg agcctttttc ctgtttcaaa cgggcagtga aggctctggc 3470581 tccctcattg ataaacgtca catgttcatc ttgataactg tcgggcgatc ctgtaaaaac 3470641 atagcaggtt ttatcctgat acgggaaaac cggtgttagc actttaacgt gctcatatgt 3470701 gctccgccct aaaatgactg tatcaacagt ctgataaaaa tcactgtagc cgttgtcacc 3470761 ttcaccttca aattcatcca gccaatcgat gcttccatct tcttttgcga tcatcccgtc 3470821 caatgaaaca gcaatgtaca gcacagtttt tctttccatg ttctcctcct atcgatgcac 3470881 catttgcccg aattgcgctt gatgcagcct gctgtatagg cctccggctt cgatcaggtc 3470941 ttgatgacgg ccttgttctt caataccgtt gtttgtgacg actacaattc tgtccgcgtc 3471001 tttgattgtt gccagcctgt gggcgatgac aagcgtcgtg cgcccctcag acaactcttg 3471061 aagcgccttt tggatcgccg cttccgtctc tgtatcaagg gctgaggtgg cttcgtcgag 3471121 aatcaagatc gacggatttt tcaagaacat ccttgcaatt gacagacgct gtttttgccc 3471181 gccggaaagc ttcacgccgc gttcgccaat catagtatcc aacccatcgg gcatgttatg 3471241 gacgagctct tccagatgcg cctgcttcac agcttgccaa atgtcttctt ctgatgcgcc 3471301 tagtcggccg taggcgatat tttctctaag cgtgcccgag aataagaaaa cgtcctgctg 3471361 cacgacgcca atctgcccgc gcaacgaaga aagcgtcatg tcttttatac tgatgccgtc 3471421 aatcgtaatg tcgccctccg atgcttcata aaaacgcgga agcagactgc aaagcgttga 3471481 tttcccagca cctgacggac cgacgaacgc caccgtttcc cccgcttgaa tggataggtt 3471541 gatgtcattg aggacattgt gatggtcatc atagccaaac gaaacatgtt tatagcggat 3471601 attgcccttc aggccggaaa catctttcga atcaggtgag tcctgaatat ccggctctgt 3471661 ctccatgagc tccatatagc ttttgaaacc cgcgatcccc ctcggataca tttcgataat 3471721 ggcattaatt ttgtcaatag gcctgaacag cacattcgtc aagagtacaa acgccacaaa 3471781 ttccccgtac gataaggagc cgcgaatgac aaaccacgtc ccgcacaaaa ggacaaacag 3471841 cgtgacaaac cgggtcagca tatagctgat tgaaccgttt ttcgccatga ttttgtagga 3471901 agaaagcttt gtgacacgaa aacgctggtt gttgacggcg aagcgttctt tttcaaatgc 3471961 ttcatttccg aacgcctgca caagccggat gccgccgatg ttattttcta cacgcgcgct 3472021 gaagtctccg atatccttgt tcagcgtggt aaatgctttg gtcatttttt tgttgaaata 3472081 aagcgctagc caaatgacga tcggcataat gataaacgtt aataaagcaa gctgccagtt 3472141 aataaacagc atcactccga acgccccgag aatggtcatg accgcaatga ataagtcttc 3472201 cggtccgtga tgggcgactt caccgatata cattaaatcg ttcgtgagct tcgacatcag 3472261 cgttcccgtc ttgttgttgt cgtaaaattt gaacgagagc ttttgcaaat ggtcaaaaag 3472321 cgactttctc atatcagtct caatattgat accaagcatg tgtccccagt aggtcacgat 3472381 atactgaaga gccgagctga gcgcgtacac cgcaaataac ccgattgagg tcgcgatgat 3472441 cagtccccag tccctgcccg gcagcaaggt atcaataaaa taattgacga tcaaaggaaa 3472501 actcagctcc attaaacctc ccgcgatcgc tgagaaaaag tcgagaaaga acaacgtttt 3472561 atatggttta taatatgaaa aaaattgccg cagcacccta tcttccccca atgtataaat 3472621 aactgataat atttctcaat tatactatac acgggctgtt ttgtaagatc agatttcttt 3472681 tttcttacag aacacctgaa aacaggcggg caaacgactc ttttgtccgg tcagccacac 3472741 ctcttttata aaagccgaca gggctgagct tttcactttc ctgcatatcc tcttcaaaat 3472801 gggcctcaag ggttcggatc gcttcggcat ccgtgaagaa cacattcact tcaaagttga 3472861 gctgaaagct gcgcatgtcc atattcgcgg taccgacgga ggcgagatcg ccatcaatga 3472921 tcatgacttt ttgatgcatg aagccttttt ggtaggagta cacttcaatg ccctcaagga 3472981 gcagctccgg gaaataggac ctcgacgcgt attgggtcaa aaagctgtcg ttcttctccg 3473041 gcaccataac ccttacctct accccctttg tcgccgctgc ttttagcgcc gtgcgaatgg 3473101 attcattggg gacaaaatag ggcgtggcga tccatattga tttctgcgct gaagaaatca 3473161 tttcataata aaggtcgctc atgctttcct tcatgtcagg gcctgtcgcg acaatttgat 3473221 aaatgcctcc tccttccacg ggaaccgggg tattgtactc ctcttgatca attagcactt 3473281 cattggagac atattcccaa tccagcataa agatagcgtg gagcgtttgc acaatttccc 3473341 cctcaagccg caggtgtgta tctctccaaa atccgatgta cggatctctg ctgatatatt 3473401 ccttcccgac atttaatcca cccacaaaac cggttttccc atcgatgatc acgattttcc 3473461 ggtgatttct gaaattcagc ttctggttga aaaacccgta tttcagcgga gaaaacggga 3473521 cgatgtccac ccccgcttgt ttcattctca taatatctct tcttgccagc ttcatgcttc 3473581 ctgccgcatc gtataaaaac ctcacctcga caccctggcg cgctttctcc atcataatat 3473641 ccatcatgcc gcgtccgagc atgtctgatt taaacatgta gtattcaata tgtatgtaag 3473701 attccgcttt tctcattgct ttgaaaatgt ccgggaaggt ttcttcgccg tttttcagca 3473761 ctttgatgtt gcttttcgta ttgatattca tatgggcagc cctgatggaa tatgtaaaga 3473821 acctctcttg attgtccttc agccctgtca cttcgggcgt ttcctccttg tcaaacagct 3473881 tcctgagctt ttccctgttg tacattcgtt ttgtcttaaa cagctttccc tttacataaa 3473941 gctgtcccga aaacagataa aacacgtagc cgacgattgg aaaaaagaca agaatatgga 3474001 tccatagcag cgtgtgctgc gaggtgcggt tttcaagaat taatgaatag atgctgaaca 3474061 aaataatgct tatatagcaa agcaatcctc cgtaaaactc aagtctggaa accggaaaaa 3474121 accaaatgac atatgccccg atgagcatca tatataaaaa gaaaaattcc agtctccttt 3474181 tcagcatcct gattctctcc aatctgattc aattacctct gtattacctc ttttttctaa 3474241 tcgataaacc ttgtaagtaa aaaacctctc cgccaaagga ggagaggttt agagaaaact 3474301 aactgtcacg gaattcatcc gcatcgtttc tgcagaaata aagcaagact attggcaacg 3474361 ccgagtgaca acatgagcgg caagctgaac ccgctcagca ctccggcaag cgccgaaaag 3474421 aaggcggcgc tgtgactgca aatacggtgg atagagtaaa tttgataccc attctgatga 3474481 gagaaaatat ataaaacggg aaattgatca gaaagatata aggagttagt caggctgaat 3474541 cataatctgg ctgttccgcc ggtttaaaat gagtaaaatc cttgatgtta tttccatata 3474601 caaacataac aggattcccg gcagcccagc cattaccttg gcagaaaaaa ccccctcttg 3474661 caagggggat tttcacgagc gtttccgata tacaacgtag ctgcgggtca gatacttgag 3474721 cggcagactg aacacatgaa ccaatctcgt aaacggccac aggataaaaa cgacgtatcc 3474781 tatcacaata tgaaacttaa accatagcgg gacactctcc atcaaagagg cgtcaggcct 3474841 gaacaaaacg atttccctga accagggccc gactgtggtc cggtaatcaa atcctttcga 3474901 atcaatgttg agaaacgtgg ccgcaacgcc tgacagcatc atgaacagca gcaggaggag 3474961 cgtaaggata tcggatggcg agctcgtttt gcggattctt ttgtcaaaca gccttctgta 3475021 cgtcaggatg acaagtccgg tacatgccgc aatgcccgcc ggcaagccag cgccaatcgc 3475081 cattttgtga tacatatgct ctgaaatgcc aagggaagca tacacgcctt ctgggatcag 3475141 aatccccatg acatgcccgc cgacaacgca cagcagtccc cagtgaaaaa gtgtgctgcc 3475201 agccgcaagt tttttctttt ctaacagctc gcttgatttc gccgtccagc caaattggtc 3475261 atgctgatag cggtaaatat ggccgccgat aaagattgtc aatacaatgt atggcataat 3475321 accccagagg atctgcccgc tcatgcctga acagcccctt caacgctttc acgtacgcca 3475381 atgttttcaa gcgcggccag cagcacgtgc agcagttcag cgtatatact gtcatttttt 3475441 tcgagacggg atgccagctc cctcacattg gacagatatt tctcaaacac gcttctcgct 3475501 gcttcaattt ctgcagccgc agcaaattcc agcatcagcg gcagataatc aggcagctct 3475561 ttctctgtcg gcaggaaacc ggattgctcg tatgtgtttt ttaaatgcag caattcaatg 3475621 ccgcgttccc tttgctcgcc tgagttaaag taggtgacat acatatttgt ttttttcccg 3475681 aagtcgaatg tatagacata gtgttcaatc agcgcttccg gagaatagct ggctgacgtc 3475741 tcgaaaaagt gcagcagctt ctcccggatt tgccggttgc cgatttcttg gataagagcc 3475801 ttccaatcgg gaagctcggc tctccactct tcatccggat aagagagaag acaggaaaga 3475861 gcagagaacg tgatttgccg gtctgtggtg ttcatcttgt tacacctcat ttatcaaaag 3475921 ttagaaacag gagccggggc cgcctgaaaa tgataagccg cagcttcctt gttcagcgta 3475981 taaatctgat acttcttctc gatggctgct cggaatcaca aagcggtcat catatttggc 3476041 aatcgcaagc agccgataca tatcttcaat ttgctgttct gttaagccga cactggagat 3476101 cagttccgga tcgattgatt tattcgtctg gaccgctctc atatactggc gcatgacaga 3476161 cattttcttt aatgttgacc gaatatgatc cgtatcaccg gctgttaaca gctgcgccaa 3476221 ataatctatc gggattctca tttggtcgat agccggaaaa atatcttccg ccgtttgccg 3476281 gctgcctttt ccttcaaaga gattcataat cgggctgagc ggcggaatgt accacaccat 3476341 tggcagcgtg cggtactcag gatgaagcgg cagcgcgatc ttccagtcaa tgatcatttt 3476401 atagatcggt gattgctgcg cggcctctat ccattcagcc ggaatgcctt gttcttttgc 3476461 cagtttggca acctcaggat cattcggatc aagaaaaacg tccaattggg aatggtagag 3476521 atccttttca ttttcaacag atgccgcttc ctccactttg tccgcgtcat atagcatgac 3476581 gccgaggtag cggattctgc caacacacgt ctcagagcag atggttggca gtcccgcctc 3476641 caaacgcgga aagcagagtg tgcatttttc cgctttgttc gtttgccagt taaaatagac 3476701 ttttttataa ggacaggatg agacgcaata tctccatgaa cggcatgcgt tttgatccac 3476761 aagcacaatg ccgtcctcct cgcgtttgta catggcgccg gatggacagg atgagacgca 3476821 tgccgggttg atgcagtgct cgcaaatacg gggcaaatac atcataaaga cgtcatcgaa 3476881 ttctgttttg atcgattcct ccatcttttg tacgttggga tcttcaagtc ccgtaatgtg 3476941 gccgcctgcg agatcgtcct cccagttcgg tccccattcg atattcatga aatcccccgt 3477001 caaggacgat ttcgggcgtg ctaccggctg gtgttttttc tgcgggctgt tcgttaatgt 3477061 ttcataatca tagttccaag gttcatagta atcatcaatt gacggctgat tcggattata 3477121 gaaaaggcct gcaagccgat tggttttcga gcccgatttc agctcgagct ttcctttttt 3477181 caatgtccag ccgcctttat atttgtcctg gtcctcccat tgcttcgggt agccgatgcc 3477241 cggctttgtt tctacattat tgaagtacat atattccgca ccggaacggt ttgtccacgt 3477301 gtttttgcag gtgacgctgc acgtgtggca gccgatgcat ttatccaagt tcatgaccat 3477361 accgatttgc gctttaatct tcaagccaat cgacctcctt cagcttgcgg atgacgacgt 3477421 tcaggtcgcg ctgattcccc gttggaccgt aataattaaa gccgtagctg agctgggcgt 3477481 agccaccgat catctgtgtc ggcttgacgt gaatccttgt cgggctgtta tgggtgcctc 3477541 cgcggttatt cgtcagcttt gtgccgggca cgttgatgtg gcggtcctgg gcatggtgca 3477601 taaacgccat tcctttagga atccgatgag acaaaacggc tctcgcgacg acaacgccgt 3477661 ttcggttgaa gcattcaatc caatcgttgt ctttgatatc cgtgtcctct gcatcatctt 3477721 tattcatcca cacggtcggc ccgccgcgga acagcgtcag catcggcaga gaatcaaaat 3477781 acatgctgtg gacagaccat ttattatgcg gcgtcaaata attgaggacg atttcttttc 3477841 cctcttgatc aggccgtttg ctcagaaacg ggcgatgctg gaggatcggt ttgaatgtcg 3477901 ccatcgtttc accgaattcc atcatcagtt catgatcgac ataataggat tgtctgcctg 3477961 tcagcgtccg ccacggaatt aatttttcaa cattcgttgt aaacggcgaa tacctgcgcc 3478021 ctcctttttc agagccggta aacgctggag acgtgatcac cgttttcggc tgggctgtaa 3478081 tttgttcgaa cgtaaagcat tcttcctcgc gttcttccgc caggtctttc agcttcaggt 3478141 tcgtgatgtt ttcaagtgat tcccatgctt ttactgcgac ctttccattc gaagtggatg 3478201 atagggttaa aatcgcttct gcagcctgct ttgcttcact tatatttgga catccctttg 3478261 ccacgctgtc cgaggtgatt tctcccagtc tctgtttgag tgattcatat tcatcggcta 3478321 ttgaccagct catccctttt gttccgctcg gctttaaagc aacgttcgga ccaagtgcag 3478381 tcattttatg aaaaatgtgt ttgtaatccc gttcaacgac ttggatgttc ggcatcgttt 3478441 ttcccggaat ggcttcacat tcgcctttgc tccagtcatt gattttgccg aatggctggg 3478501 ccaattcctg catggtgtcg tggagcagcg gtgtcgcaac cacttctttc accggctcca 3478561 tatcgacttc ttctgccaga tcggaaacgg cttttgacag cgccttgaaa atatcccagt 3478621 ctgacttcga ttcccacgga gccgagatcg caggagcaaa tggatgaatg aacggatgca 3478681 tatctgtgct gctgagatcg tgtttttcat accatgtcgc cgccggcagc acgatatcgg 3478741 aatacagcgc cgtacccgcc attcgaaaat caagattgat taataagtcg agctttcctt 3478801 ccggcgcctg ctcccgccat ttgatttctt ctgggcggat gctgtcgctg tcgtcattca 3478861 ttaaaccgtt cgttgtcccc agcaaatgct tgagaaaata ttcatgccct tttcctgagc 3478921 ttgagatcag atttgcccgc catacaaaga gattccttgg gaaattcact tcattgtcag 3478981 gatcttcaat cgcgaatttc agttttttct cttggagctg tgaggccacg tacgcaccta 3479041 cgtcttcagg tgttgctgcc cctgcttttt cagcttcttt atacagatcg atgccatttt 3479101 gattgaaagt cgggtaagac ggaagccacc ctagccgcgc cgccagcaca ttgtaatcag 3479161 cgtggtgctt gtagcgggat gaagcagcaa tcggtgatgc caaatcactg atcggctggt 3479221 cctcataacg ccactgatct gtcgcaaagt agaaaaatga ggtgccattt tgcagcttgg 3479281 gcacgccttc ccagtccttt gcagttgcaa tcgtctgcca cccttcagca ggtcggagct 3479341 tttcctgccc cacgtaatgg gcccagcctc cgccgtttac gccttgggcg cctacaagta 3479401 aaacaagatt taacactgct cggtagatcg tgtcggagtt gaaccagtgg ttaatgccgg 3479461 cccctacgat aatcatggac cggccgtctg tatcgatcgc attttgggca aactctctgg 3479521 caatcttaac gacagcttct tttttgattc ctgtcatttg ttcctgccag gcaggcgtaa 3479581 acggctcagg gtcatcatag gagacagccg atcgttcgcc gatgccccgg ttcacgccgt 3479641 agttagccag tatcaagtca aacacggtcg tgatgtacgt ttcttcaccg ttcaggttca 3479701 tttttttaat aggaagatcc cgctcgagca ctttgtttcc gtcatttgaa aaatacggga 3479761 tgcgcaccgt gccgatttcg tcctctattc ccagcacaga gagacggggt tcaatcggtt 3479821 ccccggtttc ttcatcaatc atgtgcaggt tccatttctg ctgcccgtcc cagcgcgagc 3479881 ccattgtccc ttggggtatg gcaaatgaac ttgtctgttc atcccaaacc gcaggcttcc 3479941 actgatcatg ctttgtcttc cgcccgatgt ccttcgcatg cagaaaccgt cccgctgtgt 3480001 atacgccatt ttcttttgac agagtgacga gaaatggaaa atcagtgtat tgcttcgcgt 3480061 actcaataaa acgttcagtt tcttggttca cgtaaaattc ctgcagaata acgtgaccca 3480121 tcgccatcgc aagcgccccg tcagtccctt ggcgaatact cagccagtca tccgcgaact 3480181 ttgaggattc cgcaaaatct ggactgatcg aaatgacctt agcgccttta tagcgggcct 3480241 ccgccaaaaa atgcgcgtca ggcgttctcg ttaacggaac gttggagccc catgtgataa 3480301 tatagccgga attgtaccaa tcactgcttt ccggaacgtc cgtctggtca ccccaaattt 3480361 gcggggatgc tggaggaaga tccgcatacc agtcataaaa actgagcata gggcctccga 3480421 ttaacgacat aaaccgggag cctgatgcgt ggctgatcat ggacatggcc ggaatcggag 3480481 aaaaaccgac gtttcggtca ggcccgtatt tcatcactgt atacagcaga gaggctgaaa 3480541 tcagcttcag cacctccggc cattcagcgc gcacaaaacc gcctttccct ctcgcctgtt 3480601 tataggactt cgctttttca gggttttcga cgatcgattt ccaggcttcc aatggatttt 3480661 gatgcgtctg caatgcctcc cgccacaaat tgatcagcac accgcgcacg tatggatatt 3480721 tcacacggag cgggctgtag atataccatg aaaaactggc cccccgcggg cagcctctcg 3480781 gttcaaaatc aggcatatcc gggcctgttg atggataatt caaattttgc ccttcccacg 3480841 tgactattcc gtttttcaca taaatattcc agctgcaaga ccctgtacag ttgacgccgt 3480901 gggtggagcg aacgactttg tcgtactgcc atctgtttct gtatacattc tcccaatcgc 3480961 gatcctcgcg ggtagtttgg ctatgtttat ttgaatggtg ttcgatagga gagaaataat 3481021 tcaatctcct aaacaacgga ctccttttct ttttcttcat gagagttcac tccttccgag 3481081 tcaggtgatg ctaagttcac tataaacaga gacagcgtgt ttccttgtga actatgtcac 3481141 acactctgct tttttcacaa aatgttcaca caaaggagaa ggaaggctgc gttcaggcag 3481201 gacgcttggg tcattagctg cctttcattc aaagatcaaa aaaaaccggc tctatttaag 3481261 aaccgggctc agcgttttca tcctgtgatg tatgcagata ccgcaaaaat aattgatagg 3481321 aacaaaaaac attttgctga agcatagcca aaaagttcat ttgcagctgc ggatgataag 3481381 acatcatttt cttaaatatg taatatggga tgttgagaat cagaatgtct gaagtggcat 3481441 tgactgagat aaagggcgat aaataaagcc cgcctttttc atcaatcgga aacacatcgc 3481501 ctttttccca cagcgcaacg gttttcgacc cttcagggag ccttgtgtcc ataaaacgga 3481561 cactgccttt taatacaata taaacagatt gagaatgaag aaaagatgga gactgatcac 3481621 atgaaccgcg gataaacgtg ccgtttttca gcaaggtttc gacaatggat agaggcactt 3481681 cattaaacat aggaagttgt ttcagaaata ataaatagtc acactgattc ataggaaaac 3481741 ctcctgtgct aaggatagct ttagtgtagc tcgactgagc ctgtacagca gtgatgtatt 3481801 tcacagcctg tatgatgaat gtcacttatc aggagggtga atgcatttat aatgaaagaa 3481861 aaaaggagga tttcgatgaa ggcgctgatt ccgaagcagc acggggcgtg ggcgatgctg 3481921 ctgatcccat ttttactcgg catggtcaag ggaggccccg ttatttggca tattccgctc 3481981 ttccttggtt ggcttttcct atacttagcg gtttatcccg ttacgcttgc cttaaaaaag 3482041 aaacaaagca aaccatatca aaagtggatg tgttattacg gttttcccac ctgctgcttt 3482101 ttgatgatct cggtctttca taagccgcct ctcatctggg tgggcgtttc tttactgccg 3482161 ctgtttctca tacatatgta ttttgcccgc agaaaaaacg aacgagcctt attgaatgat 3482221 gttgcaggtg tcttgttctt ttgttcgggc gggtttgcga gctgctggct ggggatggga 3482281 acccttgacg gctgggcttg gtttattttc ttgcagtctg ctttattttt tatcgggagt 3482341 tccttttatg tgaaatcggt gatccgcgag agaaaaaaca gggcatttgc atactggtca 3482401 tggggatatc acctgctgct ccccttttta tccgctcttt tcggagcagg atgggcgttt 3482461 ctcgctttta tcccgagcag cttgcgggca tggttttttc atggaaggga ttggcccgta 3482521 aaaacgattg gcattctgga aatcgtgaat gcctgcttct ttcttgccgt catgtgcctg 3482581 tttatcacaa ggtaaaaaaa caaggacacc gctgtccttg tttttttcag tcaatattgc 3482641 aaatctccag cgggcaattt tcacactcaa tctcacatcg taaatagtcc cgcttgtgca 3482701 aaataatttt tccggattcg tctatcgaaa taaccccttt tttgcggaga tctccgagca 3482761 tacgattgac gctttcccgt gcagccgcgc aaaactttgc caaatcctga tttgtcagga 3482821 caatgttaat cagaatgccg tcgcttcgct ccactccgta gctgtttgat aagcggataa 3482881 gggtagaata gagcgccccc tttttgccat gaagaagcag atccctgatt ttggactgaa 3482941 tcttccggag gtgcgtgctc atccatttca tgaactcaaa tgtcaaagcg ccgttttgga 3483001 ttaattcttt ttccagctta tttttattaa tgacgagcac ctcgccatcc tctagtactt 3483061 ttgcactgag catatacctt ggttcttcag tgaaaagtgt taattctccg acgatatcat 3483121 gcttttggca gattctaagc gtcaggtctt ttccgtcaga tgtcagcttg ccgatttcaa 3483181 tgagtcctga ttgaatcaga taaagctctt ctgcatccat tccttcccga aacaaatacg 3483241 tgtgtttttc catttttctt ttcgtgctga tcgattccag caattcatac agatcgctgg 3483301 atataagatc actatcagat ggtcgaacag agagaaaatt catgagctca cctcgaagaa 3483361 agtcacgttg tgtgtttatt gtaacgtgaa ttgatttgta cccatcgaga aaaaactaac 3483421 aatcttgtga atgccccagt gttagttgat gctctggctg tttctctccg tgtgtgtttt 3483481 cattctttcc tgccaataca tccatatgac aaggacaaaa ctggctaacg ccacctctga 3483541 aagcgccata aacccgatcg cgtactggcc tgttgcctga aatacactcg ccaatatgag 3483601 cggaggaaaa aagccgccta aaccgcccat ggcagacaca atcccattgg caatccccgc 3483661 ttgcttcgaa aaatagaaag gcaccagttt aaaaacagtt ccgtttccta tgcctgagca 3483721 gacggccacg gttaatgatc caaacgtata aaggccgatt gtcggcgaga acgataggat 3483781 aatgcctgat aatgtaagcc cggcaaaaac aaacatcaag atgcggagcg ggctcatttt 3483841 atcagccagg aatccgcccg caggcctgag cagcgtagaa accgcaataa agccagccgt 3483901 ccgcaagccg gcatctgcag gattcagccc aaaatgctcc accagaaagt tcggcagata 3483961 gatagtgaag gcgacaaagg caccgaacgt aataaaataa aacaggctca gaaaccatag 3484021 cacatgattt cggtaaacag ctttgatttg agtcttaaca gaaactttga ccttcttctc 3484081 atgcctgtcg ccaaacaata cgtgcagtaa ggcaaagaca gccagcaaaa tcagatacat 3484141 ttgcacggtt gatttccacc cgacggcttg agcgataacc ggcgctgcaa atgtcgtaac 3484201 ggctgtcccg atatttcctg caccgtaaat cccattgacg acaccgtgct tttctttcgg 3484261 ataatatttc gggagggagg tcaccccaat ggaaaacacc gctcccccga tccctaagaa 3484321 aaagccgcct gcgattaaat caaacagaga atccgcgata ctgatccaaa atacaggaaa 3484381 taaaagcagg atgaagctga ccataaacat gagccgcgcg ccaaacctgt tcgttaaata 3484441 ccctaaagga atgcggagaa gcgacccgag gatcacagga atcgcggtca ctaaagaaat 3484501 ctcacccttg cttaaatgaa tatctaatgt gatttgggaa atgagtgatg aaatcagcac 3484561 ccaaaccata aaccctgcca ccaagcttaa tgactgtaac gataattgaa tgtgttgacg 3484621 gttgatcatt tggcttgccc ctttcaatga ttcaataatc agtcttatca tacaaaaact 3484681 agccaaacag gattgtgaat tacatcacac gtttttctca taaaaaaagg acaaagcccg 3484741 aagactttgt ccttttgatc gtgattacat tttttccgga gccgatacgc cgatcagctg 3484801 aagcgcattg ttcagcgtaa tttgcgttgc cttcattaaa gccaggcgcg cgcggctttt 3484861 ctcttcattt tcagggtcga tgactttctc tgcgttgtag aagctgtgca gagcagaagc 3484921 cagatcataa atatagttag tgacacggtg cggaattcgt ttttccgctg cttccgccac 3484981 tgcctctggg aagccgccga tcgttttcag cagatcgtat tctttttctg attgaatatg 3485041 gctgaaatca agatctgccg ccggtttaag cccctgctct tccccttggc gaagcatgct 3485101 gcaaatacgg gcatgcgcgt attgtgcata atacacaggg ttttcgttag atgttgatac 3485161 agcaagatct aagtcaaaat ccatatgggt gtctgcactt cgcattgcaa agaagtaacg 3485221 cacggcatcc aagccgactt cttcaatcag gtcacgcatc gttacggctt taccggtccg 3485281 tttgctcatt ttcattttct cgccgttttt gtaaaggtga acgagctgaa tgatttctac 3485341 ttcaagcgtt cctttttcat agcccagcgc ttcgattgcc gctttcatac gcgggatgta 3485401 gccgtggtga tcggcgcccc aaacgttgat cagcttatca aagccgcggt caagcttgtc 3485461 cttatgatac gcgatatcag gaagaaggta cgtgtacgtg ccgtccttct tgatcaatac 3485521 gcggtcttta tcatcgccga aagtcgtgga acggaaccaa gtcgcgccgt cttcttcata 3485581 gacgtggcct ttttcgcgga gcgcttcaag cgccttgtcg atttttccat tttggtacag 3485641 tgaagtttct gaataccaca catcaaacgg cacacggaag ttttccaagt ccttgcgaag 3485701 cttttccagc tcgtatttca ggccgtattc acggaaaaac gcgaggcgtt cactttcctc 3485761 ttcgttaacg aaacgatcac cgtattcctc agcgagacgc tttccgatcg caatgatatc 3485821 ctcaccgcgg tagccatcct ccggcatcgg tttttccaat ccgagtgctt caaagtaacg 3485881 gacttcaaca gaaagcgcca gattgttgat ttggtttccc gcatcgttaa tgtagtattc 3485941 gcggcttaca tcgtaacccg cttttgaaag cacgttgcac aaggaatcgc cgacagccgc 3486001 cccgcgcgca tgcccgaggt gaaggtctcc cgtcggattc gctgatacga attctacctg 3486061 aactcgttca ccgtttccga tgttcgtttc cccgtatgct tcccctgctt ccagtacaga 3486121 cggaatcagc tttgttaaat attgattgtt catatagaaa ttgataaaac ccgggccggc 3486181 gatatccagt ttttcaatcg aagccttccc tttatcaaaa tgggcgacaa tctcttcagc 3486241 gatttgacgc ggcgcttttt ttgccactct tgccaactgc atcgccatat tcgttgagta 3486301 gtcgccgtgt gttttatctt tcggtgtttc taaaacaaca ttgggaatct ggctttcttc 3486361 agccagtccc gctttcagaa cggccgcttt gatttcttct ttcagcacgt ccttcatttg 3486421 ttccgcaatg ttcatgcgtg agttcctccc tcatacgtga tcgtcatatt atgtaaatgc 3486481 tcctgctcgt ctccgacatg catgtcatat gcgatgctga tacggccttt ttcttcatcg 3486541 agatcagatt gaatcgattt tgtgcttgtt ttcagctcaa gctcaccaaa tgacatttta 3486601 tatttagcaa ttgtggaagc tcccgttacg aaacgctgat tcattttgac agcgcctgac 3486661 ctcatgacca ggacttcgcc ttcgcttact ttcacaatcg ttttgacttt gcctaagtcg 3486721 tgttcttcat aataagatag atacacttta ttttgtttta catagtaaaa tccggtggtg 3486781 cggaattcga tgacttcttg gtttccgtca tcctcgatca cagacttcac atggagtgtt 3486841 atcggtgtct cttgcttcat tctgacacgt ccttttcatc attccacttt gacttgaata 3486901 gtataatcat tcggtttgta aacttcaact gcttctatct taccatcatt gctcatcaga 3486961 tttgaagata aacctcataa aaagcatttc cttatataga agagaaaatc atatcactaa 3487021 ttacctttag gaaatgttac atttttccga aatctatcat ttccttttca catttttttc 3487081 aaaatatatg tattgaatta gtaatttgat agttttaaga taaaagtaca acatagatct 3487141 gctagaaaaa caaaaaaagg gaggattcaa ttatgaaaaa agctgtcatt gtagaaaaca 3487201 aaggttgtgc aacatgctcg atcggagccg cttgtctagt ggacggtcct atccctgatt 3487261 ttgaaattgc cggtgcaaca ggtctattcg gtctatgggg gtaaggatct cccaaaaggg 3487321 catagtcatt ctactatgcc ctttttaagt aaattacaat ttttaactaa aatctacctc 3487381 ttggatatac atacacaacc gtttttcatt tgaatcatat gtatagggga tggtattttg 3487441 tttatagagc agatgtttcc atttattaat gaaagtgtaa gagttcacca gcttcctgag 3487501 ggcggcgtgt tagaaatcga ctacttgcgc gataatgtct ccatttctga ctttgagtat 3487561 ttggatctca acaaaacggc ttacgagctc tgcatgcgca tggatggcca aaaaacagct 3487621 gagcagattt tagctgagca atgtgcagtg tatgatgaat caccggaaga ccataaagat 3487681 tggtattacg acatgctcaa catgctccag aacaagcagg ttattcagct tggaaaccgg 3487741 gccagccgcc atacaatcac cacgagcgga agcaatgaat ttccgatgcc cctgcacgcc 3487801 acctttgaac tgacgcaccg ctgtaatttg aaatgcgccc actgttattt ggaaagctca 3487861 cctgaagcgc tcggcaccgt gtcgattgag caattcaaaa aaacggctga tatgctgttt 3487921 gataacggtg tattgacatg cgaaatcaca ggtggagaaa tttttgtcca tccaaacgcc 3487981 aatgagattc ttgactatgt gtgtaaaaag ttcaaaaaag tcgctgtctt aacaaacgga 3488041 acactcatgc gaaaagagag cctggagctt ttgaagactt acaagcaaaa aatcatcgtc 3488101 ggcatttctc tagatagtgt caattccgag gtccatgact cctttagagg gagaaaaggc 3488161 tcttttgccc aaacttgtaa aacgataaaa ttgttgagtg accacggtat atttgtcaga 3488221 gtcgctatgt ctgtcttcga aaaaaacatg tgggaaatcc acgatatggc ccaaaaggtt 3488281 cgggatctcg gggcgaaggc gttttcttac aattgggttg acgatttcgg aagaggcagg 3488341 gatattgtcc atccaacgaa agacgccgag cagcaccgca agtttatgga atacgagcaa 3488401 catgtgattg atgagtttaa agatctgatt ccgattattc cctatgagag aaaacgcgcg 3488461 gcaaattgcg gcgctggctg gaagtccatt gtgatcagtc cgttcggcga agtacgtcct 3488521 tgcgccctct ttccaaagga attttcattg ggaaatattt ttcatgattc ctatgaaagc 3488581 atctttaact cccctctcgt ccataaactg tggcaagcgc aagcgccgcg gttcagcgaa 3488641 cattgcatga aagacaaatg cccgttcagc ggctattgcg gaggctgtta cttaaaaggg 3488701 ctgaactcta acaaatatca ccggaaaaac atttgctctt gggcgaaaaa tgaacaatta 3488761 gaagacgtgg tccagcttat ttaggaggga aacgatttgt caccagcaca aagaagaatt 3488821 ttactgtata tcctttcatt tatctttgtc atcggcgcag tcgtctattt tgtcaaaagc 3488881 gattatctgt ttacgctgat tttcattgcc attgccattc tgttcgggat gcgcgcgcgg 3488941 aaggctgact cgcgatgagc attttggata tacacgatgt atccgtttgg tatgaacggg 3489001 acaacgtcat cttagaacaa gtggatttac atttagaaaa aggcgccgtt tacgggttac 3489061 ttggggtaaa cggcgccgga aaaacgacac tgattaatac gctgacaggc gtgaaccgca 3489121 atttcagcgg gcgttttaca ctgtgcggaa ttgaagcgga ggccggcatg ccgcagaaaa 3489181 catcagatca gctgaagact caccgttact tcgccgccga ttatccgctg ctatttacag 3489241 aaattacggc gaaggactat gtgtctttcg tccattcgct ttatcaaaag gatttttcag 3489301 agcagcagtt tgccagtttg gccgaggcct ttcatttttc gaaatacatc aataggagaa 3489361 tttcggagct gtccttgggg aacaggcaaa aggttgtatt gatgacaggc ttattgctgc 3489421 gcgctcccct gtttattttg gatgagccgc tcgtcggttt ggatgtggaa tcgatagagg 3489481 tcttttatca gaaaatgcgt gagtactgtg aagcaggcgg aaccattttg ttttcttctc 3489541 atctgctcga tgtcgtgcaa agattttgtg attatgcggc tattcttcac aacaaacaga 3489601 tccaaaaggt cattccgatt ggagaggaga ccgatctgcg gcgggaattt ttcgaggtga 3489661 tcggccatga ataacataat ccctatcatg tctttgctgt tcaaacagct ttacagccgg 3489721 caagggaaaa aggacgccat ccgcattgcc gcaggccttg tcattctggc cgtgtttgaa 3489781 atcgggctga tccgccaggc cggcattgat gaatcggtgt tgcgcaaaac gtatatcata 3489841 ctcgcgcttc ttttgatgaa cacatatatg gtgtttcttt ccgtgacatc acaatggaag 3489901 gaatcttata tgaagctgag ctgcctgctg ccgatttctt cacggagctt ttggctcgcc 3489961 cagagtgtcg ttttgtttgt cgatacctgt ttgagaagaa ctttattctt ttttatttta 3490021 ccgctgttct tatttggaaa cggaacgctg tcaggggcgc aaacattgtt ttggctcggc 3490081 aggttttcgt tttttaccgt ttactccatt attttcggag ttgtgctaag caaccacttc 3490141 gtcaaaaaga agaacttgat gtttctgctg catgcggcga tattcgcctg tgtatgtatc 3490201 agcgccgctt tgatgccggc cgccacgatt ccgctttgcg cggttcatat cctgtgggcg 3490261 gtggtcattg actttcctgt ctttctgcag gcgcctccgc agcagggcaa gatgcattca 3490321 tttatgcggc gatctgaatt ttcgttttac aaaagagaat ggaaccgatt tatctcttct 3490381 aaagcgatgc tgttaaatta cgcggtaatg gcggtattca gcggcttctt ttcgttccag 3490441 atgatgaaca ccggcatctt caatcagcaa gtgatttata tcgtgatttc cgcgcttttg 3490501 ctcatctgct cgccgatcgc ccttttgtat tcgattgaaa aaaatgaccg gatgctgctc 3490561 atcacgcttc cgatcaagcg aaaaacgatg ttttgggcga aatatcgctt ttattcaggc 3490621 ctattggcag gcggatttct ccttgtcgtg atgattgtgg gtttcatcag cggccgttcg 3490681 atttcagttc tcactttttt gcagtgcatt gagttgctgc tggcgggagc gtatatcagg 3490741 ttaactgcgg atgaaaaaag gccctccttc agctggcaga cggagcagca gctatggagc 3490801 ggtttctcaa aatatcggtc ttatctgttt tgtcttcccc tattcttagc catattagcc 3490861 ggcaccgctg tatccttggc ggtcattccg atagccggtc tggtcatagt ctattacctg 3490921 caaaaacagg atggtggttt ctttgataca agcaaaagag aacggcttgg aagttaacct 3490981 gctgaagact catcaatttt caactatttc aatcgccgcg agctttctga aaccgatcga 3491041 aagcgcggcg gaacctgagg aagaaacgat ttatttttac ggcgccgccg catacctgaa 3491101 ggagcaaatc attgacgctt ttggttatgc tgccggcagc cgtttcatgt actcagcgaa 3491161 tctctttttt gatcagcagc tgaaaacctg cgggacccgt ttgattcacc cattatataa 3491221 cgggaatctt catgttgacg ccctgatgaa aacttttgca gacttgtctt tcccttcttc 3491281 tctttcattc gaagcatttg aaaaggccag gaatgagctg ctgctgaaaa tcgaaaagaa 3491341 attcactgat cccttctcct actcggcggc tcgcttggct gaggaggtct tcggaaaccc 3491401 gatgtacggc acaggcatgt ttggccggag agacaggata aaggcgattc atcctaaacg 3491461 gtttctcgac gcaacggact ttatcgttga tttagtgtcc cagcaaaaac agctgaacat 3491521 attgggacaa gtacaagcat gtgatgttcg gggacatgcc ccgcaaacgt ccgctgtaac 3491581 gtccggaaga atacccgtaa accggcatgt ttttgaaaca gagacacgca gcgctgcagg 3491641 tccttccgtc ttgacactcg gatttgactg cggagagatg aaagatgcca gcgattatat 3491701 caaaatacag ctaatagacg gattactggg aaagtacggc cattccgctt tattcaagca 3491761 cttcagagag aaggatctgg cagtctatca cgttatcacc cgttacgatg tcatgaacaa 3491821 tttgctgctt gtttcaatat gtacagatca gcttcatgag aaagacattc ccccgcgcgt 3491881 tttggaagct gtctcagctt ttcatacaga tgagcgggaa ctagaacagg caaagcagtt 3491941 tttacgcaat gaattgctgc tgcaattcga ttctcccgaa ggtctattgg cctatatggg 3492001 ggtcctgcgc cgcttctcct gcacgaaaga agccttgctg gatggcatct cagcggttac 3492061 atgccgtgat gtattgcaat tcatagcgac catcaattat atcggagctc atgtagtaag 3492121 gggatgaaga gatggaaaag aaagcctttt ttcaacagct ggatgaacga accgatatca 3492181 gatacacaga cagcggacta aaaatattca gattgaaatt cccccgcgcc cacctgcggc 3492241 tgtgcaatgt aaaaatcgat tttggaagcc gggatgtatg tatacgggca gaatccggtg 3492301 atacactgct tccgtatggc acagcacatt ttttagagca tcttctcttc tggcataacg 3492361 gccgcaatct gtacagtgat ttttttgcgc atggcgcgct tttaaacgca ttcactacct 3492421 acaccgatac caatttcatg tttacctcat taccggatcg gctcagacaa acgattccca 3492481 tcctgcttga tgctttatgg aaccactcat ttgacaagaa gattgtcgct caggaaaaag 3492541 ctgtgattac aagcgaaatt caaacagcac accttaacca tcagctctca tatcattatc 3492601 agctgatcag catgctttct ccctcctcac cagctgccgt tttccccgca ggcagaatcg 3492661 aagatattga ggcgctggac atcagtgatt tacaaaaagc ctataaggct gcctaccaag 3492721 cccatcggat gacgctgttt ttgattgggg gctcagaaaa tacagaaacg cttttgcctc 3492781 ctcacctcca gctggaaaag cgtccggatt atcatgctga aagaaaaatc atcccggcat 3492841 gccctccagt cctctcacaa aaaatgatgc tgggtgatga ggagcggatg gaagatacct 3492901 ggaccggatt acagatcggc gcacttcccg ggcaaaacga tctgttgtcg ataaagcttt 3492961 attgggatat cgcggctcgt attctatttc aattagattc accgtttttt caagagattc 3493021 agcaaacgta ccgcctggaa atcgatcgct tgtcagccga gacttatata tatgaggatg 3493081 gcggtttctt gatccttcac agtcaaggga cccattcttc agcttatatc gatgtggctt 3493141 catactatgt cacacagaag aaagaacagg ttgccgcctg gcttcaatac ggcaaggact 3493201 ctttgacaga cgcgatcatt tatgacagcg attatgtgcg taaatgcttc gagtgggcag 3493261 ccgagtgtga caggtgcgat tgctcgtttc ttgacatgta ccacatcatt caagatatgg 3493321 atgcgcaggt tttcttgtct ctcattgatg caatggcatc ttctaacaaa gcgatcattc 3493381 acgtttctca gaaagaggcg atcagacaat gaaacaaagc actgtcttta cccttttatt 3493441 gctgcttata ggtatggcgg cttattcctt cggctgggtt caggccgttg ccgaagccgc 3493501 cgcccaatat gtacagatga tcaacaatga tgctgtgcgg ctcggactgc tggcttgtac 3493561 cgctgccctc ctgatgctgc ctgcttttct ctatcttcac tatgtcaccc aatccgtgaa 3493621 aaacatgaca gcagcttttc agaaactcac acagtctcat caaagctgct gtgactttca 3493681 gcaacacaac ttgtgcagcc gatatgcaga agacgtcaaa tcgctgcgtg acagctataa 3493741 aaacgtccgc caaacatacg tgatggctgc cgtgttgtgc caagtcatca tattcggctg 3493801 catgttcgaa atcgttaaag ccgtcccttt ccgccttcat acgccccctg ccttttcaat 3493861 gggacttgcg atgctactga tcctgtattt attgttttgc atgcgaacgt atttgcggca 3493921 gcttttccgg cacggcagcc tgttcagaaa agtgtttgcg ggagcactgg cagcagccgg 3493981 gatttggtgg atgctcagtt tctctataag tgaactgctg tttctgatta tcctggctgc 3494041 cattcagcaa atcggatcat ttatttataa acgattctct tatcacagca ccgcttctct 3494101 tgatctataa aatagctaca tcgcaatcgc agacggaccc gcgccaaccg gaatcaccgt 3494161 cacggctgta taatcacttg tgcggtacac ggtcacagca ttgtcgttgg gctgtgccgc 3494221 ataaatatac tgtttgtccg gcgttacggc gaggtcaaag gcgccgggga gagacacgtt 3494281 tgcaatgatc ctctgtctgg ccgtattaac tacgtataag ttattaatga gaaacggttc 3494341 actatatggc tctagaaaat aagctctagt actatcgaga gaaaatacaa tcgtcctcag 3494401 cgtttcaaat aaacggctga agtcccctcc cctgcttaat ggtgacaaac taatctccgt 3494461 tacacctttc ggccacagct caccattcaa tacgtacgca aaatttccag cgtaaggagt 3494521 tgtaattaaa ctgggaaatt caaatgtatc tatgatactt tctaccaact gcccagtatt 3494581 tacatcatat ttatcaaccg accaactgct tccattagcg gtatagacat actgtccatt 3494641 cggatcaaga gcaaagtcta aagcgccggg tatcggaatg acatcaatga ccgattgaga 3494701 ggccgtgtta atcacatata tagatccggc ggccatcacg tatgcgaact catctgttgg 3494761 atcaaattcg atttttctcg gccctcctcc aacagtaatg gtatttatga tggttaatgt 3494821 tttattatca atcactgaga caaggttggt atttccatgg aggacatacg tgaatgcttt 3494881 atcgaaagta acgcctagat tagttggcac gtcagaaaaa gggattgttt ttacaacagt 3494941 gtttaaatct gcatcaataa ccgaaaccgt gctgtctcca gtattggcag taaacacata 3495001 cgattgaggg tctggtgatg gcggtaaaac aagtgtcccg gccaccgtaa gcggactgcc 3495061 gtagaaaggc ggtacaatga gcagatcttc cactgttatt tgactgaaat caggacagcg 3495121 gccagactgt gctgcataat aaacaacttg atcaatctct tcagtatgaa tcacagaaac 3495181 agccccgtct ccttgtccat attgatttcg tacaggcgac acactgacaa gaagcgtaat 3495241 ggtcccttgt actctcacag catatcgaac accgatatct tctggttccg gcccagtctg 3495301 gattaagcaa ggctcactga tacaggacaa attgtctgta ctccatgtaa cagccgctga 3495361 cgcttcggcc gtatcaacct tgaagccctc agggaaatct atcggcactt gaaacggcgc 3495421 ttcccggcta atttcctcat cacaaaaaca gaaacaattt tcctgtaaag cagaaagatc 3495481 attctttttc atgatttcac gtccttttag aaatgcacaa catgcagcgg ttaaatcgta 3495541 atggcacccg gtgaaacccc aagagatatc acagtttcct cagaataatc atctgtgttg 3495601 taaacaatga tgctctgctc tataaaacga gttgcataca gaaaatcgcc attcggggta 3495661 aacgcatagt ctgttgctga ttgcggaaca tttcctataa cgcctgctcc atttggactg 3495721 acagaatata aattgccagt gaagccgtca tataaataca cctctgctcc actcgtaaac 3495781 attcgatatt ccccttcata ctccagctct tgggtgctgc tgatggtaaa cgtatttaaa 3495841 tcaataaccg tcaaataatt aaaaaagaat tcttgttcta atacataggc ataccgctcc 3495901 ggccaatttg tttctatggt tgatacgata agctctcgtt caattgttcc tgtgacttca 3495961 ccggtagtta ggtccacttt ttgcactatt ccaaaattca gaacataggc gaataaccca 3496021 ttgggatcga ttgcaacatc atatccttcc acaggaatcg acctatccac agttaacgta 3496081 tcaattccaa tcacataaac cgcagtaccg gtgaaaacat aagcaaactc atgattaggg 3496141 ataaatctaa tcaatcgagg cggctgatcc agcaatatag ttgctgtcac tgttaatgtg 3496201 tcataatcga tgacagaaat cacattattg ttgggatgta agacaaacac agcgctttta 3496261 tctggcgtaa tttcaatacc tgccggattg tacggaagag caatcgttgt cacaacagta 3496321 tcggtgtttg tatcaatcac agaaactgat tgatcatttg gattcgctgt aaacgcgtag 3496381 acgggttccg gctccggtac aagcacaatt gtccccgtca ccgataaagg actgccgtaa 3496441 aacggcggaa caacaacaag gttctcaatc gtgatgtcac tgatatccgg gcaatcatcc 3496501 gattcatcgg aataatagac gacttgatcg atttctgcat tgtgaatgac ggaaacagcc 3496561 ccgtcccctt gtccatattg atttcggaca ggtgagacac tgacgagtag cgtaacggtt 3496621 ccctgcaggc gcactgcaaa ttgaacaccg acctcatcag gctcaggccc cgtttgaatt 3496681 aagcaacggt cactgacaca agaaaggctg tctgcattcc acgtcacgtt tgcaacagct 3496741 tcagccggat caacgacaaa cccttcaggt aattcaatcg gtgcttgaaa catggcttct 3496801 cggcttgctt ctccctcaca aaaacataag cactcttctt gttctgctcc tgctttttct 3496861 ttaaaggaaa gcttgttttt tctcattcct tcacttcctt ttcagacata cactgctcac 3496921 gcagatataa cagaatatgg aagggtaacg tgtttgcttg tacaaattgc tgagggtaaa 3496981 cgcttctttt tgaaaatata tctccaaaca tgcggtgtaa cgaaagaaaa aattgcggtt 3497041 tttttgcgct tctcacaaga atgttgatga taaaatatga catatataga attatgaagg 3497101 gagggatttg caaacgtgac aggtgtcata tcttcttctt ccatcggaga aaagattaac 3497161 gaatggtata tgtacatacg ccgattcagc atacccgatg cagaatattt gcgacgagaa 3497221 atcaagcaag agctggatca aatggaagaa gatcaagacc ttcatttgta ctattcactg 3497281 atggagtttc ggcacaacct aatgcttgag taccttgaac cgttagaaaa aatgaggatt 3497341 gaggaacagc cgagactgtc tgatctgctg cttgagattg ataaaaaaca ggctcgttta 3497401 actggtctgc ttgagtacta ttttaacttc ttcagaggca tgtacgagct ggaccagcgg 3497461 gaatatctgt cggctattaa atttttcaaa aaggccgaaa gcaagctgat attcgttaag 3497521 gatcggatag agaaagctga gtttttcttt aagatgtctg aatcttatta ctatatgaaa 3497581 caaacgtatt tttcaatgga ctatgcacgg caagcatatg aaatatacaa agaacatgaa 3497641 gcttataata taagattgct gcagtgtcat tctttatttg ccaccaattt tttagattta 3497701 aaacagtatg aggatgccat ctcacatttt caaaaagctt attctatggc agaagctgaa 3497761 aagcagcccc aattaatggg gagaactttg tacaatatcg ggctttgtaa aaacagccaa 3497821 agccaatatg aggatgccat accttatttc aaaagagcaa tagctgtttt tgaagaatca 3497881 aatattcttc cttccttacc tcaagcgtat tttttaatta cacagatcca ttataaatta 3497941 ggaaaaatag ataaagctca tgaatatcat agtaagggaa tggcttattc acaaaaggcc 3498001 ggagatgtaa tatatttatc agagtttgaa tttttgaaat ctttatactt atcaggcccg 3498061 gatgaagaag caattcaagg attttttgat tttctcgaaa gtaaaatgtt gtatgctgat 3498121 cttgaagatt tcgctattga tgtggcaaaa tattatcatg aacgtaaaaa ttttcaaaaa 3498181 gcttctgctt attttttgaa ggtggaacaa gtaaggcaac ttattcaagg aggagtgagt 3498241 ttgtatgaaa ttgaagtcta aactattact ctcttgtctg gctctaagca ctgtgttcgt 3498301 ggcaacaact attgcaaatg cacctacaca ccaaattgaa gttgcacaac gaggaatgat 3498361 ttaaccgccg tccatcggcg gttttttcgt cccctcttta ccaaagtctc ccaatccatg 3498421 ctatgatctt ttcaataatc ttgaagagag tggaaatgca gcatgtctct aaaaagtgtg 3498481 agaacccact ttactcaatg gaatcgagaa aatgatgtga cggagttcga aacgtcgagt 3498541 gcgacagttg aacaggcagc tgagacaatc ggcgtaagcc tgtctagaat cgccaagtcc 3498601 ctgtccttca gaggggaagg agatcaggtg attctgattg tggcagccgg cgatgccaag 3498661 atcgacaaca aaaagtccag gcaaacattt ggctttaaag caagaatgct ctctcctaat 3498721 gaggtgctgg agcagacagg ccatgaaatt ggaggagttt gcccatttgg attggctcat 3498781 gatcctgagg tttatcttga tgtatcgctg aaacggtttc agactgtttt ccccgcatgc 3498841 ggcagcagaa actccgctat tgaattaaca ccgaaagaat tatccgaatt ttctttctca 3498901 aaagtgtgga ttgatgtttg taaagactgg gaataaaaaa acatccagac atcgtctgga 3498961 tgtttactta tttcacaaac ccaagcagca tttcacggat gattttgctg gctgtgtttg 3499021 ccgtttgctc tgagtggtcg tataccggcg cgacttccac taaatcagcg ccctttacgt 3499081 ttacctctga acgcgcaatt tcatggaccg atgcaagcag ttctttagac gtgatgccgc 3499141 cggcgtcaac cgttcctgta cccggtgcgt gtgcagggtc taatacgtca atgtcaattg 3499201 tgacataaac cggacggccc gccagcttcg gaagcacctc tttcagcggt tcaagcactt 3499261 caaattttga gatgtgcatg ccgttttcct tcgcccattc aaactcttct ttcatgccgg 3499321 aacggattcc gaatgaatac acattgtgcg gtccgatcaa ttctgccgcc ttacggatcg 3499381 gcgtggagtg agaaagcggt tctccctcat aatcaacacg aagatctgta tgtgcgtcaa 3499441 aatggataat cgcaaggtct gggtatttct tgtacatcgc tttaatgaca ggccatgaca 3499501 cgaggtgctc cccgcccata cccattggga acttcccttt ttctaaaatg ctgtccacgt 3499561 actcttcaat catatccagg cttcgctgcg gatttccgaa cggcagcgga atgtcgccag 3499621 cgtcaaagaa gttcaagtca gccagatcgc ggtctaaata tgggctgtat tcctcaaggc 3499681 cgattgacac ctcacggatt ctgcttggac caaagcgtga gcccgggcga tagctgactg 3499741 tccagtccat cggcatgccg taaagaatgg cgtccgcctc ttcccactcg ggacggctcg 3499801 cgataaatac ttttcctgaa taagcttcat caaatctcat ctataatacc ctcgctttcc 3499861 tgtaaaaaag cgcaagattc gctcctgcgc cataccttca ttatttaatc aggtcactca 3499921 caaatttcgg cagaacaaac gccgctttat gaatatcttt tgtgtaatat ttcgtctcaa 3499981 tatcgaagaa acggctgtct tccactgcaa gcggatcata ttttttcgag ccaattgtaa 3500041 atgtccacaa accgcttgga tatgtcggaa tgttcgccgt atacagcttc gtaatcggga 3500101 agatttcctt cacgtcgcgc tgtacatttg tgattaattc cggtgtaaac catgggttgt 3500161 ccgtctgcgc aacgaaaata ccgtcttctt tcagcgcttt tgcgattcct gcgtagaatc 3500221 cttttgtaaa caggtttaca gccggtccga ctggttcagt cgaatctacc atgatgacgt 3500281 catattgatt ttcagatttt gcaatgtgca taaatccgtc atctacctgc acgtcaacgc 3500341 gcggatcatc cagtttgcct gcgatagaag gaaggaactt tttagagtat tcgataacct 3500401 tgccgtcaat atctacaagt gtcgcttttt tcacgcttgg gtgcttcagg atttctctga 3500461 taacgccgcc gtcaccgccg ccgactacga gaacgtgctc cggatttggg tgcgtgaata 3500521 atgggacatg cgccaccatt tcgtgataaa cgaattcgtc tttttcagat gtcatcacca 3500581 tgccgtccaa aaaaagcatg ttgccgaact cttctgtttc caccatttct aaatgctgaa 3500641 actccgtttg ttctgtatgt aacgtcttgt taaccttcat cgtaatgcca aagtttttcg 3500701 tctgcttctc tgtgtaccaa agttcgctca attgtcatct ccctttcgag gctgtattca 3500761 tttattgtaa gcgtcttatc agcttttatt ctcggttgaa atctcatttt cacctaagga 3500821 aaaagtatag aggatggcgg ggaaaaagta aagatgcgtc ctgttctgcg atgtttaaaa 3500881 acgatctttt tttctcataa tagtagaaac ataaaaaaag ggggaacccg ttgtggatgc 3500941 aatgacaaat aaacggctga gactgacgct gaaaaccgtt cgcgccttta tctttttagg 3501001 ggcttttgcg gccttggcgg cagctgctgt gtttatgact gtcattttga tagccaaata 3501061 ccagggcgct ccctcggtgc aagtgccgca atccacgatt ttgtacgcga gtgacggctc 3501121 aaagctcggg gaaacgaact acggcgaaaa gcgctattgg gtccccttaa aggacatgaa 3501181 tccgacgatc gtaaaagcga cagtggcgat tgaagaccag aatttctacg atcatcacgg 3501241 ctttgattat aaacgcatgg ccggcgcggc gcttgctgac ctgaaagcat ttgccaaggt 3501301 tcagggtgca agcaccatca cccagcaata tgcgagaaac ttataccttg aacacgacaa 3501361 aacgtggaaa cggaaatgga atgaggcgtt ctacacgatc cgtctggaac aaaactattc 3501421 taaggacgag atattagaag gctatttaaa tacgatttac tacggccacg gcgcctacgg 3501481 cattgaagca gcttcccgcc tgtatttcgg caagcatgcc aaaaacctga cggatgcgga 3501541 ggcggcgctt ttggcaggaa tcccgaaagg cccttccggc tattcaccgt atgtcaatga 3501601 gacgaaggcc aaggaacgcc agaaaacgat tgtgcggatg atggaaaagc agcagatgat 3501661 cagccaaaag aaagcggatg aattgatcaa ggaacctctt tcctatcagc ctttgaataa 3501721 acaagtttcc aagagaaagg ctccttattt ctacgacaat gcgatgagag agctggaaaa 3501781 aaagctcggc atgacacggg agcaaattga aacgagcggg ttaaacgtct atacaacggt 3501841 agataaacgg atgcagcgca tcgccgagga gaccattacc gaaacggtta acgcgggctc 3501901 tgacattcaa gtcgggtttt cagccattga tccccgcacc ggaaacgttc tcgcccttgt 3501961 cggcggcagg gattatcaaa aaagcccgtt tgaccggacg acacaggcga agcgccagcc 3502021 tgcttcgacg atcaagccgt tgctgtacta taaagcgatt cagagcggat ttacgccagt 3502081 cactttgatg aaaagcgaag aaaccgagtt tcaaattgat gcaaagggag aaacctattc 3502141 tccaagcaac tataacggat actatgccaa caagccgatt acgcttctgc aggcgctggc 3502201 gctttccgac aatatttacg ctgtgaaaac gcatcttttt ctcggcacga acaaacttgt 3502261 aaagacggca aaggaattcg gcattaccgc ccatcttcaa gcactgccgt ccctggcact 3502321 cggcaccgaa cccgtacgtc cgattgagat ggtcaacgcc tatgccatgc tcgcaaatgg 3502381 cggaaagaaa atcgaaccga cttttatttc aagagtaacg gacgcagccg gccacgtgct 3502441 gtacgaaaac ccgaatcagc ataaacaggt gcttgatgaa aaagccgctt ttgtcacagc 3502501 gagtatgatg acaggcatgt ttgatatcga tttaaatgga tatacgtcgg ttacggggcg 3502561 aacgatagcc aaccgcctga caagaacgta tgccggaaaa tcaggaacca ccagcgcaga 3502621 cagctggatg atcggcttca atccgaagct ggccgccggt gtttggaccg gctatgacaa 3502681 aaacagcacc atcgactcgg tcgaagaaaa aagctatgct aaaaccattt gggcggactt 3502741 catggaggac gcgctcaaag gcgaaccgga aaccgcgttc aagccgccaa aaggcgtaac 3502801 cggtgtgtac attgatccgg aaacaggcta ctcatcaggt cccggctgcg ccgctaagca 3502861 ttacacatat tttgtgaaag ggacagaacc cgcaaacgtg tgctacgggg cagaacccgc 3502921 aaaacaaaca aaagaccggc ttccatccaa agaaaagccc gcttccgaga aaaagtggtg 3502981 ggacaaatgg ctggggcgac atcattgaaa ataacccggc tcctcggagg ccgggttatt 3503041 cgtatggttc cttcataatc gatggaagaa tgttagacaa tcgagctgaa caatcagttt 3503101 tgggataaag tggtgaattt ctcatttctt cggcgctggc tttcatctcc cagtcgccga 3503161 ctcatatccc cctaaaaatg aaaaaccccg agtcttgttt cggctcggga ttttccatgt 3503221 cctatttctg tatcaccagt ttactcaatg tttacgaaaa atatctcaaa tactttaaaa 3503281 gttcacaaaa aattcataaa ttaattgttt tctggaagca ggctcgtttt taactcatct 3503341 gaggaacggt cccataggcc ctgatcatgc tttttcagaa attcgcctag tacacgcttc 3503401 gagctgtcgt ccattttatc aacgatgatt ttccgtttca tggatttatc catcagattc 3503461 acatgctcag gcagtgactt gtagcctctt ctgatgcttc tgtcgaccgt catttcacag 3503521 gctgtcacac cagcgtaata aggcccctct tcttttctgt caatcgttac ccacacaagc 3503581 cagtatggtt ttccgttcgg cacttcttct ttattcggga gaaatttaat tcctttttca 3503641 acggtgctgc gggcatgcat agcgccgatg tctacgaacg cttctttttc ctctacatca 3503701 acgaatacgg gagaaatgtt atcaaggctg agtgccccta cgccaaaacc gccgtgtccg 3503761 tctgtcggat cacttttgat aatattaaac ccgattgatt ttttcttttt ttcttccatg 3503821 aagttctacc tcctacaaaa gcggttgaaa tatcgctgaa aacagcttta aaatcgaatc 3503881 tcttcctgca ttgagcatcg gccacagcac gtaagatcct agcggtgtca caaacagcac 3503941 caaaaatacg ataaagccgt agctctccgc ctgcgtcatt ttggcacgca cgcccggcgg 3504001 aacgagatct tctataattc gatagccatc gagcggagga agcggcagca gattaaataa 3504061 aaacaagaca agattcagct gtatccaaat agaaaaaaac tgatccagcc ccgtgctgaa 3504121 cgccgcaagc atttccattc cgtacgcatg catcaacact aacaaaaaga aaccaataaa 3504181 cgcaagaatc aggttactga cgggcccggc tatagatacg agcacaccag caagccgggg 3504241 tttcttaaag aaacggcgat tcacgggaat ggggcgcgcc cacccgaatc cggccaccag 3504301 aatcaaaatg gttccgaacg gatcaaggtg tttaatggga ttcagcgtca gtcttccttg 3504361 ttttttcgcc gtatcgtcac cgaatttgta tgcgacataa gcgtgggcaa gctcgtgcat 3504421 cgtaaacgac acaattagcg tgatgacgag gtatggcatt aaagataacg gataatataa 3504481 aaaacggtcc aagtgagata tccctctttc tcaaaatgca agaatttact ttattcagta 3504541 tactataaga agcctctttt tctaaagaga ggaaacgaga taaaggagga ttcagcaccc 3504601 atgccatacg taactgtcaa aatgctcgaa ggccgtacag acgagcaaaa acgcaatctt 3504661 gtcgagaaag taacagaagc cgtaaaggaa acaaccggtg cttctgaaga aaaaattgtt 3504721 gtctttatag aagaaatgag aaaagaccat tatgccgtcg caggcaaacg cctgagcgat 3504781 atggaataat ctctataaag ccggcgcttc gcgcaccggc ttttattatc cctattgagc 3504841 cagcttcgca ataatcgcca agaacgtctt tttctcttcg gctgttaaac gttcaaacat 3504901 gccatcaatc agctgctggc ggttttcgat catttgttca gccgctcccc ggcccgattc 3504961 agaaagagta atccatacag tgcggcggtc attgttattt ctggatctct caataaaccc 3505021 ttcctgctct aaatgattca gagctgtggt cgtggcagag ggagacagtg tgacctcctt 3505081 caaaatatcc tttatggtgc agctcccatg tctgtatatg atccgcagaa taaaccctct 3505141 tacattattc acgtgtttcg gaacggtggc ttcatctaat tgcttcgtgc ttttcaaata 3505201 ctttgtaagt gcgtgatcca gcaaatttgc ttccagtttg tcatggtcca tgtcaatttc 3505261 cccatttcga gatgcattca taacatacga acgatatgat ttacttatta ttttactgat 3505321 tccgaatagg gaaagtcaaa aaagcaaaat gtgaattcac agcttttatc ctacatgcct 3505381 cgattttcca cctgtttcac aagtttatct ttaaaagttt ggaaaggaac gtgttcattc 3505441 tgctgatgtc cgaatcggcg gacgtttacc gcattctcct gctcctcatg atctccaagc 3505501 accagcacgt acggaatttt ttgcacctgc gattctctga ttttatagcc gagcttctca 3505561 ttgcgctcat caatgccggc tcttatcccc gcctgcttca gctccgcctg cacttttctg 3505621 caatagtcta agtgaacgtg cgaaaccggt atgatttgaa cctggatcgg tgcgagccag 3505681 actggaaaag ccccaccgta atgctcgatc aaaatgccga agaaacggtc gattgagccg 3505741 aaaaccgctc tgtggatgac aacgggacga accttctcat tgagttcgtt gatatatgtt 3505801 aaatcaaatt tttccggcat ttgaaaatca agctgaattg tcgcgcattg gtggctccgt 3505861 ttcagggcat cttttatatg gaaatcaatt ttcggcccgt aaaacgcccc atcgccttca 3505921 ttgatctcat aagagaggcc aagctcctca aggacgcgtg ctaaggcacg ttccgacgct 3505981 tcccaaaggc tgtcatcgcc taatgaatcc tccgggcgag tcgaaagctc aacagaatac 3506041 tcgaaaccaa atgtccgata tacctcatca atcagccgaa tcgcttcttt gatctcactc 3506101 tcaatctgat cctcccgaac gaaaatatgg gcgtcatcct gacagaacgt ccgaacgcga 3506161 agcattccgt ttaaagcgcc gctgtattca tggcggtgca cctgtccgaa ttccgccatg 3506221 cgaatcggca gatcccgata agaatacagg ctgtttttaa agatgagcat gtggccgggg 3506281 caattcatcg gcttcattgc gaatcttgta tcatccactt ctgaaaagta catattgtcg 3506341 cgataatggt cccaatggcc tgactgctcc cataaccgct gattcatcat aaacggcgta 3506401 cgcacctcat cgtagccggc atttgtttgc agctcacgcg agaagcgctc cagctcattg 3506461 cggacaatct gccctttcgg caaataaaac ggcatccccg gcgcttcttc agaaaacata 3506521 aacagcccta actgtttgcc gagcttgcga tggtctcgtt ttgccgcttc ttctagcata 3506581 tgcaggtgcg catccaaatc ttttttcttt tgaaacgcaa ccccgtacac ccgctgcagg 3506641 acttcatttt tgctgtctcc gcgccaataa gcgcctgata ctcttgtcag tttgaacgcc 3506701 ttgatcatcc ctgtagaagg aagatgcggc cctcggcaca ggtcaacgaa ttccccttgc 3506761 tggtacagtg tgatatcctc cccgcgcgga atatccttta aaatctcaag cttgagccgc 3506821 tcgtcttttt gtgcaaacag ctcttcagct tcttcgtaag aaacctctat acgtttgatt 3506881 tcaaggttct catttattat gtttttcatt tctttttcga tggcctctaa gtctcctgat 3506941 gccaagcttt tccccagctt catgtcatag tagaagccgt ctaaaatcac aggccctacc 3507001 cccaatgaca cttcgccgta cagccgtttt actgcttggg ccagcacgtg cgctgttgtg 3507061 tggcgaagca cctgcaagcc ttcttgtgaa tcgagtgtga caatcgaaag ctcagcatcc 3507121 tcctccagct tgaaactgag atcaacaagc ttgccgttga cctgacctgc ggccgccttc 3507181 ttttgcagac tggaactgat cgaaccagcc gcttctttga ttgtgatgcc tttcggatat 3507241 tcctggatct gtccgtccgg aagctgaatg tgtacatgtt tgctcatttt agaacactcc 3507301 ttattcattg ttgtatataa aaaaacacac ccgtcccgca gatagggacg agtgtgtgat 3507361 taacccgtgg ttccacccaa gttcccgaca aatactatgt tgtcggctcg gtgctgtaac 3507421 gcagcataga cggcattggt tacttcagtt ccccaatgct gctccaaggc ggtaaatgat 3507481 attcctaagc tgggaagctc tcacctttcc ttccctctct gaaaaccgta actatcattc 3507541 atgtcctttt catcgcatgt attcaattca taaaaaaaca cacccgtccc acagataggg 3507601 acgagtgtgt gattaacccg tggttccacc caagttcccg acaaatacta tgttgtcggc 3507661 tcggtgctgt aacgcagcat agacggcatt ggttacttca gttccccaat gctgctccaa 3507721 ggcggtaaat gatattccta agctgggaag ctctcacctt tccttccctc tctgaaaacc 3507781 gtaactatca ttcatgtcct tttcttcgca tgtattcaat tcaaataaaa aaacacaccc 3507841 atccctctaa aagggacgaa tgtgttgatc atccgtggtt ccacccaaat tcccgatcaa 3507901 ttacacatga tgatcggctt aaagatgctg taacgcagca tgacggtatc agatacttgt 3507961 tttccctgat acggctcaaa ggcggtaagc tgctttccct gcgttaggaa gatctcagct 3508021 gtccttccct ctctggaaac cgtaaaaagc atctcgtgtc cttatcagtg cctgttgttt 3508081 caataatttt ttatatctta ctatatattc ccacaaagcg caatcagtga tttacatttt 3508141 ttctgacgcg gcagtcccgt tatgggcagc cagaaacagc catacaagca atgcagcgag 3508201 gctgtatgcc gctcccatca tcaaaaacgc aaacccggca ccagcatacc aagtggcgga 3508261 cagatgaatg atcaccccgg ttatcgctac gccgaccaag gctccgattt gccggtttgc 3508321 atttaacgcc gcaccggcga tattcgtatg tctttgcccg gcagcctgca tgatcacagt 3508381 tgtcatggca ggaactgtaa taccggtaca gaggttcata acagacatca acaccgccag 3508441 ctgccaataa ggaaaatccg gagaaatcag cacaaacaac agcaatgcaa tgatacagct 3508501 gaccgccatt gatacaaaca taagctgacc ggcttcaaac cgattcgcca gacgggcaaa 3508561 cagcagattg ccgatcacga agaccgccat catcggcagc agctccactc cagccataaa 3508621 ggaacttgcc cctcctgctt cctgcaaaaa aaggctgagc ataaacatgc cgccaaaaag 3508681 ggcgaaattc agcaaaaacc cgataaattg ggcagctgag aagcggccgt ttttgtataa 3508741 ggacgccggc aggatgggtg tttttgcaga aatttcccgc agcaaaaaca gcacaaatgc 3508801 caaaaccgct gcagtaaatg ctacaagaat cactggcgag cgccagcccg ctgaaggccc 3508861 ctgtatcaaa gcataggaaa gaaacccgag agccatcatg ccaagcagat gcccgatgat 3508921 gttcacgcgg ctgcttttcc caggaacgcg gctgaggatt cggtaagctg aaatgagcgc 3508981 agcagcccct attggcacat tgatcagaaa aatactctgc cagcccgcca actgtaccag 3509041 cacgcccccg ataaaaggcc caagggctga agcggcggaa acaagcgcgg cccacagtcc 3509101 aaacattctc gcccgcgccc gctcatcaag gtaagaggca gccaaaaggc tgagtgagct 3509161 tggcataaac aaagctgccc caattccctg tatgagacgt ccggcaatca gcatctgccc 3509221 atttatagat gcagcgcata gacaggaggc cataacaaaa acggctagac ccaagatata 3509281 gatcgtcttc gagccgaaac ggtcagccaa ggctccgccc gccagcagaa gcgacgcaaa 3509341 agtaagaatg tacccgtcca caacccacgt tacacctgaa agtgacattg aaagagtgtt 3509401 tttcatatca gccatcgcca cattcacaac ggtcacatca agagttgcca tgaggaaacc 3509461 aagtgcgagc acgatcagca cggatatgcc tgttgatgat gttgattctt gtatagaccc 3509521 gctatttttc attacaattg ccctttcact tgcttgatta cccaatcatc tattttttca 3509581 agatcataca attccccgac tctgtccata acatgctgca aggattcttc tctcataaga 3509641 ttggaccatt tatcctcgat ttccgccatg actgtctcca gcacacagtg actttcaccc 3509701 tcaaatacag attgcagcaa gcctttcccc tgatacatcg aacctctgcc ttcgaccgct 3509761 tgataaacat cataaagcgt aatgtcagcc aaaggcttcg tcagggtaaa accgcccttc 3509821 gtccctggta aggattctgc caaaccggct tgaaccaatg ttctcatcag cttcttcaag 3509881 taagacggag acacgcgcaa tcgctggctt atagcctctg acgtcaaaga agcctgtacc 3509941 ggcagccgtg acagtaacag cagcacagaa accgcctgct ccattcctga tttcattttc 3510001 atcctattca ctcctgattc attatggata actattatcc ataatgaatc tcttagcagc 3510061 ttttgtcaat aaaaaaagca aaagaaacgg atcatttctt ttgcttggta tggttaacaa 3510121 atctgcttca gttcctctat gtattgaagc gcttcgtcat attcttcatt tgtatatttt 3510181 tgcttgcttt tgatggtaaa gactttttct ttcttttcct catcctcaag cccgtcaaag 3510241 taaaggatcg tggaaaccag ctctaaaaac cgtgatgaac ggctgtttac actgtcgata 3510301 tagcctttca tatccggcat gtccagatca gcatggtcta aaaatgcgga gcctgtctca 3510361 gtcagcgaat accggtattg aaagtagccg cccttttttt ccttcacctc atgcagaaat 3510421 ccaaggttgc acagctcttc aatctggagc gtcagttcct ctgaatatgg tccgtaaaag 3510481 tgaaaatcat atttctcata gaaaggaaac tgcattttct tggcgatata aatcattttc 3510541 tgcagcttct ttcgcccgat gatttctcca gaatccgaga acaccttcat cagttttgca 3510601 tgttctttca acaaattccc gacatctcct ttttccttct ttccaatttc tatgtcagtc 3510661 ccagcagctg ccggattttc attttcgctt ccggatgttt agtgccgtca caaatcaagt 3510721 cctttggata gtacagcttg tggtccgtcc gccgtttacc tgagatggat tccacaatag 3510781 ccgactgtct ggacagctct ttaatttggc cgttttgcgt caagagatgg atcggcagac 3510841 gctcctcttc ctctcctggt cggtaaaaat cgtatggcag atctgatgaa gaatcaacga 3510901 ccaaataata gctcggatcg atccccgcct ctttgaacaa tgaagtcagc tcaaaataag 3510961 ccgacatttc ttcattcgga ttgaattcaa cgtattggaa aagctggcgg ttaatgaatc 3511021 tgcggcacaa gtcggataaa atcgcgtctt cttcatcctc ccaggcctgg aagtaataca 3511081 aaataataga ttcatccagc tttacataat cctccagtgt caattttcct tcaaaaatag 3511141 aatagaaatg aaccggagcg tgagtgaaga catagccttc atcgtgcagc tgcttcgccc 3511201 tgtgaagaat cttcgttaaa atgacctctg cacttctagt cacaggatgg aagtagacct 3511261 gccagtacat ttggtaacgg ctcatgatat agtcttcgac agcgtgcatt ccgctttctt 3511321 taatgacgat ctgatcctcg cgcggccgca tcacccgaag aatccgctcc atatcaaaat 3511381 ggccgtagct gacgcccgta taatatgcgt cgcgctggag gtaatccatg cggtctgcgt 3511441 caatctgact cgaaatcagg ctgaccactt gcttgttttt atatgttttg gcaatgactt 3511501 cagcaacatc ctgagggaaa cccgggctca cctttctgag cacctgatta acctccgtgt 3511561 ctcccaaaat gatacctctt gtaaaatcct cgtggtcaag gtgaaagacc ttttcaaatg 3511621 aatgcgagaa cggcccgtgc ccgaggtcat gaagcagcgc cgcggccaaa cagagttcgc 3511681 gctcactgtc atcccattca gggcggcctt taaagacgtc atcaaccatt cttctgacaa 3511741 tttcatagac accgagagaa tggttgaacc ggctgtgctc agccccatgg aacgtcaaat 3511801 aggtcgttcc gagctgctta attctgcgga gacgctgaaa ttcacgggtt ccgatcaaat 3511861 cccatatcag cttgtcccga acatgaacat agcggtgcac cggatcttta aacacttttt 3511921 cttctgataa ttttccattt ggatacgcca tcgtcattcc ctcttttttt tagccgtgtt 3511981 tctattatat cgactctatt ctttgaaaac atccttgaat ttgcccggcg atttgttcca 3512041 tcttcatgaa aaacacatct tgtgaagcaa aaaagcctga cctgagggcc gaggctaaga 3512101 aaaaatatgt ttttactttt ttattttctt ttttactttg tcaatcagct catcctctgt 3512161 cggagctgac agcgggcgat tgttcacaaa agcaaatgat tttttccgtc cgggcccgca 3512221 ataagattgg catcctacct caacctttgc gtccgggtcc acttctttca aacgcggcag 3512281 caatgttttg atattagtgg cttggcaatc atcacacact cgaaattcat tagccatgac 3512341 gtacgcttcc cttcatttct atgttcatct atgtgaataa cctaaaatca cgtttcaaaa 3512401 aaaatcacat cacacttcat tttacaagga ttcgactgtt cctgcaagcc gctccatcct 3512461 tcgtatctcc tattctttca gccaatttgt ataaatattt tccaacctgg acattctaat 3512521 accatgaaaa gaaaaatggg agttgagata aatgacaaaa cagcgacaag acgcttggtc 3512581 agaggaaaac gatctgcttt tagccgaaac agtgcttcgg catgtgaggg agggcagcac 3512641 tcagctgaac gcctttgaag aagtcggcga taaattaaac cggacatccg cagcctgcgg 3512701 attcagatgg aacgcagtgg tccgccatca atatgaaaaa gcgcttcagc ttgcgaagaa 3512761 acaacgaaaa cagcggatga gagcgctcgg aaacgggcag cccgcgaaaa aaagattatt 3512821 atatcagcct cctgccgttg atcctgaaat cattcaagaa accgctgcag aagagccggt 3512881 taaaacggaa acaccatctg tcgaaaatga gcaaccttta atgtctggcg aacacatgcc 3512941 ttttgttgat gaaagcttta aggaagagtt agctagtcta tcacacttat tgtctcctca 3513001 aacgcctgca gctgcgcctg agatgacgat gaatgatgtg atccgcttcc tgcagaatta 3513061 cgaaggcaat cacgagcaat catcagcatt aaaaatggaa aacgagcgtt taaagaaaga 3513121 aaatcaggaa ttgcaaaaca aaacagagca gctagaggca gaagttcaaa agcttgaaaa 3513181 agaccaaaaa acgatccaag aagattatga aaccttggtg aaaattatga acagagccag 3513241 aaagctagtt ttatttgaag aagatgaaca tgcctctccg tccttcaaaa tggaccggaa 3513301 cggcaattta gaaaaattag cggaatgaca tagaaaaatc ccaaaacggg cagctgtttt 3513361 gggattttcg ccatgtgcaa aatccccttt tctattgaga aaagagaatt tcctcatttt 3513421 gcagccggat cagctattct tgtaaaatga ggccaagctt atgtgaatct attaagacat 3513481 gtgagctgcc tcggccgttt tttgtttccg aggcgcagca gaaatgacca aaagccccag 3513541 catcataagc gcaatgccca gccacgagga aggcgaaagc atttccccta tgaaaaacac 3513601 gccaagcaat gaagccgtca gcggttcagc taaagacagc gtgaccgccg ccgaggccgg 3513661 aaccccggta agccctttcg caaacaaaaa gtatgcggca catgttgcaa ttaacccgat 3513721 gtaaaggctt gttcccagtc ctctaggggt caatatccac gagatatcta actgccataa 3513781 tagcggcgtc agcaagatgg cgctgatcat gaatacaacg gcggaggtcg ctcgcggagg 3513841 ctgggttttc atcatcgctt tactgatgag cgtatagcct gcaaaagaag cacccgctcc 3513901 aagcgccata agaacaccag ccacatcaat ccgaacattg gaactgtcgg aaaacagaag 3513961 ccagcaaccc gctaaagcca gcacagtcgc aatccaccag gagtttcgcg ggcgtttctt 3514021 caatacagcc cattcgaggg tcccggcaat gataggcgca ctgccgatgg caatcacagt 3514081 tcccactgca attcccgttt ctttaaccgc tgtgaaaaac agcggctggt aacacgccat 3514141 acaaacagcg gctaaaaata cgagcggcca tgcccaattt ttcacgtgaa gctcccggct 3514201 gatccaaacc gcaagcagca tggcgcttcc tcctattaat aacctgaacg ctccaaatgc 3514261 cagcggtgtg gcgctttctg gagccaatgc ctgaacggtt cccgtggtcc cccagaaaaa 3514321 agccgcaatc aatacaaaaa ggctgtaaat attccccttc atctgcctct cccctttaat 3514381 atggatgctg atgtcatttt atcgtttttc tttttgtcgt ggttatctgt atgtaagaag 3514441 gacttatctg aaaataagat tattgaggta aaatgccgct tgagataaaa aatgcatgcc 3514501 ggcatataca gccggcatgc gaagaacgtt cacccaaata cctttgcatt ccgctcagcc 3514561 atccggacga ggtttttctc aaattccatt tcctcatcaa tggacagtcc agctgaataa 3514621 agatgggtgc ttaacgcttt taattccgtc aataaagcga acattaagtc ttgtacggag 3514681 atgtcttttt gaagaagctc acttaaggac gccatcgttt ccggacgtat ttccggatag 3514741 acgccttttt tatcgttttg tttgtctttc agcgccgctt gatagaatcg tctgatcaag 3514801 tcggcccttt cactgccgct tttatctgca cagagataaa tttgaacagc gactccgccg 3514861 cgaacgcgtc tctgagagat gccggcgaac tttttgccat ttatactgag gtcatagctg 3514921 ccgggacaat aagacccttc aatttcatag gcttcgatct ttgcgttgta cggtctcagc 3514981 attcgtctca tcagctcgac catcgcttca tatcctttgt ctatatcgat gcctttcttt 3515041 tcgtcctcga atatgagaga gatatttaaa acaccgtcat ccaatacgac ggcaagaccg 3515101 ccggaattgc gtacgatcac acggtatcct tcgctctcca gcaaggagat accatcctgc 3515161 aaaaacggga ggcgtgtatc ctgtattcca aggacaattg tatcgtggtg cacccatgag 3515221 cgcgctgtcg ccggcgacac gccttttccg acggacatgc atagcgtatc atccattgcg 3515281 aaggattgct tcgcatcaaa taaagggccg agactggatt ggtcaatgac tctccatttc 3515341 ggctgcatca gtaaatcaat cggttggttt gccatctatg taaaaccctt tcatgttagg 3515401 cttattgaac gaaaactatt atatcatttc agcagctgtg attgataatt gcttttcagc 3515461 atcgtaataa aaatttcttt attttttgta ttctccatga gaggagaatg aatgtaagac 3515521 agcttgcgct ttaacgagaa attattaata tgcagaattg aaatttcgcg gtggatcaaa 3515581 tccttacgca gcacgcttct ggatagaacc gaaagtccca tgccgttaat caccgcttcc 3515641 tttacacctt gattgctgct gatggtaaac attgatttcg gccgaagtcc atttgaactg 3515701 agtacatgat cgagatattc tctcgtcccg gagcctttct ctcttgtcac ccacgcttcg 3515761 ttctgcaaat cgctgatcga aatctctttc cgcccggcga gcggatgctg atttggagcg 3515821 gcaatgcaca tttcatcctc catgaacggt tcaatttcca gctcattctc gtttgtatgt 3515881 ccttcaatca gcccgatatc agcctgaagc atccgcacac gctcgctgac ctcctctgta 3515941 ttgccaatca tgacatctag attcagctct ggatacagct tttgcagctg ggccaatagc 3516001 ggcggaagaa tatactcacc gattgtaaag cttgcagcta ttttcaattc acccttcaca 3516061 tagtgatgat gcgcatagat ttcagccttg gcttgttcgt agagaaacac catttgcttt 3516121 gctctttgat ataaaatgtc tcctgtcggc gttgtcgtaa agtgttttgg cgacctgttc 3516181 agaagagccg tttgaaattc tttctcaaga tttttgatat gcagactgac gctgggctgg 3516241 gagatcatca gcttttccgc cgcttttgtg aagttttttt cttctaccac cgctataaac 3516301 gttttcagca cgtcgtaata caaaaacccc acccctgtca ttaatgaaat atatggttat 3516361 gattagtttt ctttattgta ctcatatcat ccgtcttggt aaagaagggc tatacagaag 3516421 cgcaaaaaag gcagccctcg gtcgagagct gccattgtct tcaattttat tacagtgctt 3516481 gcgccgctgt aattaatgcg agattgtaaa catcttcagc gttacatcct cttgaaaggt 3516541 cgtttacagg catatttaaa ccttgcagga ttggtcctac cgcttcaaag ttgcccaaac 3516601 gctgagcgat tttatagccg atgtttcctg cttcaagact tgggaatacg aatacgttag 3516661 cgtccccttt gatctcggaa tccggcgctt ttttctcagc tacagatgga acaaatgcag 3516721 catcaaattg gaattcgccg tcaagtgtca gttcaggcgc tttttctttc gcgattttca 3516781 ctgcatccgc tactttttct gtttcatcag attttgctga gccttttgta gagaagctga 3516841 gcattgccac gcgaggctca atgtcgaaca tttttgccgt attggcactt tcgatcgcaa 3516901 tctcggcaag atcttggctg tcaggtgcaa tgttgatcgc gcaatctgcg aatacgtatt 3516961 gctcttctcc gcgagccatg atgaacacgc ctgaagtctt tttcacgcct tcttttgttt 3517021 tgatgatttg aagagccggg cggacagtgt cagcagttga gtgagcagct ccgcttacaa 3517081 gtccgtctgc aagtccttta tacaccagca ttgtaccgaa gtagttctcg tctaataatg 3517141 ctttacgagc ctgttcttca gtcgctttgc ctttgcggcg ttctacgaat gcttgtacaa 3517201 ggtcttccat gccttcatat gtatgaggat cataaatctt aacgccgccc agcgtaaggt 3517261 tcaattcttt tgcttttgct tggatctcat tttcattgcc gatcacaatc ggattcagca 3517321 ctttgtttcc tgcaagcttg ctgaccgctt ctaaaatacg ctcgtctaag ccttcaggaa 3517381 atacaatttt aacgtctttt ccagctactt tttcttgcac tgttgaaaat aaatctgcca 3517441 caataaaacc tcctcaaaaa gttacaaaaa cgctttcttt tactagcata ctcttcttcc 3517501 aatcaaattc aaacagccaa ctttcattat agcgctttca taaaaaaatc ttatttttct 3517561 aactaattta agtgactcaa tcttccctta taggttcttc tattttgatg gagttatacg 3517621 gaagggatgt tcaaggtttc tccacagtag aatcggataa actatggtat agtgaaggca 3517681 atcatgaaaa gataatggga gtgaagataa atgagtgaac agcaaatgac gaatgaagcg 3517741 gcaaaaacgc ttgacggctg gtatgcgctt catgatttcc gcacaatgga ttgggcttcc 3517801 tggaagcttc tgtccagtga tgagcgccaa tctatcatac atgaattcac cgggttgctt 3517861 gaaaaatggg gcgtagccca aaaagaagga aaaggatcgc aaactcttta cagcatcgtc 3517921 ggccaaaaag ctgattttat gctgatgatc cttcgtccta caatggaaga attaaatcaa 3517981 attgagcttg aattcaacaa atcaagactt gctgagttca ccattccggc atactcctac 3518041 gtatcagtgg tagagctgag caactacttg gcaagcggtg acggcgatcc ttatgaaaat 3518101 ccgcatgtgc gcgctcgcct ttaccctgaa ctgccggaat ctaaatatgt atgcttctat 3518161 ccaatggata aaagaagatc tggcaacgac aactggtata tgctttcaat ggaagaacgc 3518221 agaaacttga tgagaagcca cggtttaatc ggccgcagct atgcgggcaa agtcaaacag 3518281 atcatcaccg gctctgtcgg ctttgacgat tacgagtggg gcgttacatt atttagcgat 3518341 gatgtccttc aattcaagaa gctagtgtac gaaatgcgtt ttgacgaagt cagcgctcgc 3518401 tatggcgaat ttggttcatt ctttgtcggc aatcaccttt cgcttgatac acttcctcaa 3518461 ttcttatatg tataatatcc cctcccgccc tatccggcgg gagtttttca attctccttt 3518521 atcagaattt aaataaaatt tgctattttc ttcgtttttt cttacgatgt agataataat 3518581 ccattttttt caaaggggtg cagttatttg tcaaaacgaa ccgcatttgt tatgggagcc 3518641 agtcaaggga tcgggaaagc aatcgctctg aaattagcag accagcactt ttccctcgtc 3518701 attaattcgc gaaatttgga taatattgaa tctgtcaaag aagacatttt ggccaagcat 3518761 cctgaggcga gcgtcattgt ccttgcgggc gatatgtctg accagcatac gagagcgggc 3518821 atttttcaga aaatcgaatc tcaatgcgga cggcttgatg ttctgattaa taatatcccg 3518881 ggcggcgcgc ctgacacatt tgataactgc aatatagagg atatgacggc cacgttcact 3518941 caaaagaccg ttgcctatat tgacgcaatc aagcgtgctt cctcactgat gaaacaaaac 3519001 gagtttggca gaatcatcaa cattgtcgga aatctgtgga aagaacccgg cgccaacatg 3519061 ttcacaaaca gtatgatgaa tgccgcttta attaacgcca gtaaaaatat ttccatccag 3519121 cttgctcctc acaacattac tgtcaactgt ctgaatcctg gttttatcgc tacagaccgt 3519181 tatcatcaat ttgtggaaaa tgtgatgaaa aagaacagca tatccaaaca gaaagcagaa 3519241 gaacagattg cttccgggat tccgatgaaa cgggtcggat cagccgaaga aaccgcagcg 3519301 ctcgccgcat ttcttgcctc tgaggaagcc tcctacatca cgggacagca aatttccgct 3519361 gacggcggca gcatgaaaag catataaaaa catcccgctt tttagcggga tgtttcttgt 3519421 aatgacccga acggcaggtt cagcttttga atccgcgtga caaattcccg cagatcctcc 3519481 tgcttcgaca ccattgagat tctgacatgc ctttttccgt tgcttccaaa aatttcgccc 3519541 ggtgtgacta cgacatgggc atgctccagc aagtaatcgg aaaattggtg agatgtctca 3519601 aacgtattcg gaatttcagc ccatacgtaa aaggttcctt ttggcttttc catcttccag 3519661 cccagttcct tttcacaaag cgccgtaaaa aagtcaattc gttccttata aattcgtttc 3519721 aacgattccg tatgctccgg atctccagaa agcgccgcac tcgctgcctg ctgcagcccg 3519781 ccgaacatgc cgacaaatac atgatcctga aattcattga cggcctgaat gattttttcg 3519841 ttcccaaccg caaacgccat tctccagccg gccatgttaa atgtttttga aaatgaataa 3519901 agctctgctc cgacagtttt ggcatcctct gcctcaagaa agctggccgg tttttgatcg 3519961 aattcaaacg ccccgtatgc aaaatcatga atcaaatgga tgttatgctc tttcgcaaaa 3520021 gcagcagctt ttgcataaaa agccgcatca gccacagctc cagtggggtt gttcggatag 3520081 tttaaaaaca taagcttcgc tttttccagc acggctggat caatcttttc aaaatccggc 3520141 agatagccat tttcttcata cagcggcatt tcgtaaagct cagctcgcgc catcgtaatc 3520201 cctgataaat attcaggata gcctggattc gggactaaag cgatgtctcc cggattgagc 3520261 aggcattgtg tcagcacata caatccggct ttcccgcctc cgaaaagcgc gacttccgtt 3520321 tcaggattga ttgtcactcc gtattccctt ttatagaaag cggcgatcgc ttcctttaaa 3520381 aaaggatagc ccctgaaagg gccgtatcca tgaaacgaag gattcagaga agcctcccgc 3520441 aaagcctcga caatatgcgg cggagtggga aggtcagggt tcccctgtcc gagattaatg 3520501 atatgggctc ccgttttttc catttccttt accttttgaa aaacgagaga aaactcctgc 3520561 cttggaagtg tcttgatgac atcggacggt gttatttcca tctaaaagac tcctttttgc 3520621 tccgttttgt tatcccgttc caaaaacgat ttgttgacga gcttcgtatg caaaaacaaa 3520681 ccgcatacga tcacgacaat cagccccata atgaccggag cgcttaggat gttaatgaac 3520741 attgaaccaa tagaaatgca taatccgata gacgcttcgg ccactgaaaa aatgcgccct 3520801 tgaatctggt ttgccgcatt ttcctgaacc ttcacttttg caagcacttc cccgtattcc 3520861 atcgcgatga aaaagaggat cgccgcgatg acagaaacag cgaatatcgg tgtgaataaa 3520921 aacagcgcca gcgagacaat ggataaaacg gtaaagtacg tcaggcctct attgttgtta 3520981 aagccccatt tgctgacaag cgccgctccg ataaagccgc cgaagccgat gcagaacgtg 3521041 agaataaagt tgccgatttc cccgtcaccc agaaagcggc tgacaatcgg aaaatagctg 3521101 tacacaactc cccacagcaa agccattgta atcatcgtaa acatggcgtt taatacgaat 3521161 gaattggttt tgatttcctt gagtccttcc ttaaaagact gaaaggcctc tttaatgttt 3521221 tcagattgaa tcggcacaaa ttgcagcttg atgcggctga taaaaaatgc cgaaaccaag 3521281 tatgtcacac cgttaaaggc aacagccagc tctacagatc cgcctaacag aaagagccct 3521341 ccggcagccg ccccgacgat aatggagatg gttgtcgctt ttgcaaataa cgtgttgatg 3521401 cttttaatat ctgattccaa ggacgacatg acagcgagac gggcgggatt aaaaaacacg 3521461 ccgcttccat aagtaataaa cagcagggcc agaaaaatca gcggatactc gccttttgga 3521521 agaaatgtga gccccaaaaa gatgatgcct ctgatgatat ccgtccacag catgatctta 3521581 attctgtcta accggtcgac cagaacaccc aaaaacggct gaaacaccat cggaatgctt 3521641 ctgaccacga tgaccccgga cgtcacccaa taatcgtgat aatatgtaga caaaatgagc 3521701 agggcaggga gaacacaata gtctcccatg aacgatagcg cctgcccgta aagcaagtat 3521761 ttagagttgg gtttcagctg tttcatactg gcagcacata ctttgccgtc agcttcgcat 3521821 gctgctgaat ttgtctgatt gattcagcca catcctgtga attactgcct ttcagttcaa 3521881 atgcagcaat ggaattgaaa gcttcaaaca atgtcaaatc aactgaagtg cctggtgctg 3521941 cggccgaaaa agaaacgatt tcagtatccc cttttaaaag cccgtccgga atatcgatcg 3522001 cttcaatgac caaatcctca gcagtttcag gaatttggcc attttgtttg aaatgctgcg 3522061 ggtacaaatg gcagtcggca acataataag gctcttgatc caataatccg tccggcagat 3522121 cggcgtcttt tccgaaacag aggacatcta ataataattg cgccatatca aggccaaaga 3522181 cctttttaat attggggatc atattccagc cggcaaatct ggctgccgac tctattaaac 3522241 ccggttctct gtttttcatt agcttgatct ctgtatgtgt tgcgcaattt tgcagtccaa 3522301 gcccttcatt tgcctttttg gcagcttcga caattttctt ttttgcctct tcatccagaa 3522361 tggacggcgt aatgtgggat gtctctgtaa acccgatttg cggcgtttta tcatgaatgg 3522421 cgatcgggaa atactcaccg tcagccatga tgccttctat actgatatag tcggagtacc 3522481 cttctgtttg ataccagtct ccgtactcac cctgtaaaaa ttcttcagcg ataaacggcg 3522541 cttcaaacgt aaccgccttt ggcacgttaa ttgatttcag atagtcattg actctgttaa 3522601 attcatcttc tgccgtctca gtgtccgtaa tcagcgttac accgatagaa ctcgctaagt 3522661 atgtaggctt taagataaga ggtgtgccga tctcttcaag agcagcacgg aaatcttcaa 3522721 gagttgtgac tcgtttgttt ttgatcgatt tgactccggc cttattaaaa gcgtccctca 3522781 ttttattttt atctctggca ttttcggctg cctgcacgcc ggcacctctc aagcccagac 3522841 gttcacaggc tttcgccatc ggagcaatga ataattcatt gtttgttgtg atggcatccg 3522901 ccccaaacat ttcggcaacc ttgacgattt gctcgacgac ctcttcctca ggcttgttat 3522961 gatcttcatg cgcccaataa atggaatcag ggtgttcaaa atcagctaaa ctcttaaaat 3523021 agtctttatc ttttatgacc gcgaccgagt atttttcaat caatgctgca tgggaggctg 3523081 taattgcaaa aggtcttgga ataaagctga ccaggttata tttttcagca gcgcttttat 3523141 aaaacatgtg cggcgggcag cctccaagat cagcgatgac caatactgtt tttctctcca 3523201 tatgtaaaac actccttctc tattgtgcgg tgtatcctcc gtctgcggtg atggcgcttc 3523261 cggtcatata gcttgataaa tccgaggcta aaaacagcat cacatttgcg atttcttcag 3523321 gtttcccaag cctcagcagc ggatttacct tcgctttttc ttttttaatc tcttcaagtg 3523381 tgccttcatt attttcaagg aatgattttt cattcagcgg tgtgtcgatg atccccgggc 3523441 atacgcagtt cacccgaatt tgatgtttcg cataatcaac ggccattgat ttagtcagct 3523501 gcaaaacccc gcctttgctg gcgttataag caggaatatc aggccatgcc acgagtccgc 3523561 cgacagagca cgtattaatg atgttgccct tgccggcggc cagcatatgc ttgagtgcat 3523621 gtttgctcat taaaaacatg ccggtcaaat tgacttgcag caccttgttc caatcgctga 3523681 gctccatctc gtgaataggc gccacgattt cgatgcctgc attattaatc aagacatcga 3523741 gcccgccaaa tgtatgaacc gccgattcaa ctgcgtgctg gcaggcagct tcgtctgtga 3523801 tgtccgtttg cacaaagtgc agcctgtcat tattttcttt tcgtaccatt gcttctcctt 3523861 gcgcttcatc aatatccgcc acaaccacat tggcctgctg gcccaaaaaa gcctgaaccg 3523921 cagcataacc aatgcctgat gcgcctcctg tgatgaggac ggttttatcg gtgaggttca 3523981 tgatcattca tccgccttca ttttttttgc ttttgccctg ttatagcgcg gcgggaagaa 3524041 gatattaatc gattttgatt ctttttctga acggttgatg gcaccatgat cttcgcgagg 3524101 ctcacagaaa taggctgtgc cgaatttcat ctcgactgtg cagccttcga ccgtcatgtc 3524161 atagccgccg ccgatgcaga tgcctatttg ttcattccga tgtttatgga aaggcatttc 3524221 tccgccattt ccagggattt tggcaagcat aatttctacc caatcctcaa caaagaacgt 3524281 gacttccatg cccggcagca ggtctcttgt tttgaaaata tccaaaaagt agtcctcagg 3524341 acttgtatat gtttcatcag ctttcagccg cttgatatca atagcaatca cttcttggtc 3524401 tgtgtcgttt cttgccccgt gaggcacatg cggcggcgcg atataggcag attccaaggc 3524461 tgtcattttt cttgtcacat ctccgacagt catcatcagc tcgccagaaa cgaccatgcc 3524521 gatttggacc tccttatgct gatggggttc aacattggta tgcggcggga cgtaagacat 3524581 taatacttca gtatcccctc gtacggttga atactgcctc actccgtttt cccattcaat 3524641 taatttcggt gtcgggaaat aaagctcctg catatcttct ttagttttca tcatcaacgt 3524701 ctccttttcc aaataatgac cagctcattg gaatgctttt gaatgttttt acaaaggtta 3524761 gcccgtactt ttgccgtgca agctcattgg ttaaggcaat gtcatacaaa ccttctttta 3524821 cttttcttgc ggcttgactg gttgaattga ctagtttgaa acgaacatct ttgcgggtaa 3524881 aatattttat taaattaata ggtgaaggat gtgaaacaat aacagatgta tcaagcatat 3524941 cgtctctgaa ttcaaaatca ggacgaacag ccaggccgta catcggtgta tcgcacctga 3525001 agatctgcaa tagctgcaaa tccggcctca tgtagaaatg cttaatgcca tcgtaagcat 3525061 gtgggacgat ggtatattcc agcgggcttt ggagcgtcct ttcgatgcac gattcaaaag 3525121 tatcatgcaa ggacaattta ctgttcagcc cttgtagaag agtaaaattg gaaatgaaat 3525181 gctttgctgc gtactcactg cttgtcccct cagggccgag cgtgttgact gtaatgagtt 3525241 tggatagtga atcagttctt ttttttgtct gaatgctatt atccaatata atcatgagca 3525301 ccaaccaatc ttttaaaatt ttaagtaaat tttatccagt ggaaattgaa ctgtcaatgt 3525361 tttttgaaaa tattgataat tattcccata caaacaaaaa aaccctttaa aaagggtttt 3525421 taattatagg aatttagaaa ctttgtttat tgagataagg actgatcggc cttctgctca 3525481 agtttgccgt actttttata tgcgaataca ctgagcacaa atccgaggac tgtgatggcg 3525541 gcgcaaatca atccgacagc tgcatagccg tatgccacat atacgggtcc cattaaagca 3525601 gaacctaatg tcacggccag attcgaggcg agactgtaaa acaccatgac ttttcctcga 3525661 tgacgctctg agcagtcact caaaatggtg ctgagcagcg tcaccgtcaa actttgcatt 3525721 aatccccaaa taaataggct ggcgattaac agaaacatag acgccggcgc atatggtaaa 3525781 cacgccagca gaacgctgat gacccccagc gcaatcaaaa gggagcgcat ttttccgatg 3525841 cggtcggcta tctttcctgt aatcacactc atggaaaacc cgattccata aatcatgata 3525901 aataagcccg cagccgtgtt tcctccggta aaaacgtcct gaagataggt gcctaaaaag 3525961 gaatacatac cgtaaaaacc aatcatatta caaaaggtta ttgtgatata aacaggtaca 3526021 cgagggactt tcagcgcatc ccggaatgtt cctgcgggct cttctatttc ttccttgccg 3526081 ctgtttttat gttgggcatg gcggcgcatt tcaaggagaa tcagcagaac aactaaaaca 3526141 cccatcaggg cgaaaatcca aaacgtccat ctccaatgca ggacgccgcc gataaatgat 3526201 ccgagcggca ctccgaaaat cagcgccagc gaccagcttg aaacgatcag tcccatcacc 3526261 ttgccccggt atgtataagg aacacgatca ccgacaactg cgtaagcggt cggaacaaac 3526321 gctcccgcag ccaatcccga aagcgcccgg cctaaaaaga agaaaaaaat attttgagct 3526381 aaagcgcata tcaccgttcc tatgataaaa atcataagcc cggccaataa gctcagttct 3526441 ctggagtatt tatcgcctaa tggaaccaaa agcggcgcac cgataaaaat cataacgccg 3526501 taaatactga tagataacgc aaggacgctg acatctgagc tgaaggcttt tgctaaatcc 3526561 ggcagcagcg gtgagatcac aagctcttca gatccggctg caaatacccc catcgttaaa 3526621 gccagtgcca acaataacgg aaaatgatgt tttgttttga tgtcattgtt ttgattgctg 3526681 ttcattcttt ctcaaacacc tcttccataa tcttcttatc ataaagttgt attatagttt 3526741 agcattgttt tttctctatt tacaattcga acgaaatatt tataagtttt attattttca 3526801 tttaaatccc attatatatt tctatatttc attctaaaaa tacatgagga tgtaacacgt 3526861 aaaaaaagct ctccggcctc ccggagagct ttttctattg cgcctctgtc tgcttttttt 3526921 caatcgtttc atgatttata cgctttttga tgcttagatg atagtatgca taacagaaaa 3526981 taatgatcgg cacaccgcag tataagccaa ttctttgatc cggaatgaaa ataaggctga 3527041 tcaacacgca gccatataaa caaaatccga gaatcgggac tagcggataa agcggcgttc 3527101 tgaactccag atcattcaca tttccgcctt ctgccaggaa acgcctgcga aagaaaaatt 3527161 gcgacgcaca aatggacatc cacgcgacaa ctgtcaccat gcccgagatt gagatacacc 3527221 ataaatacac tgtttctgca gccatgacac ttgtcagcag cgaacagcct gaaatgccta 3527281 gcgtaatcag cagggcattc atcggcacgc ctttttttgt cagtctggtg agaaaggagg 3527341 gacccatttg atttgatgaa agtgaccaca tcatacgcga cgccgcatac aatcccgaat 3527401 tagcaacaga taaaatggcc gttaagatga caaagttcat gatatctgcc gaaaatggga 3527461 tgccgatttg atcgagtact gctacaaacg ggctttcaat cacccccgcc gttttgtacg 3527521 gaaggatggc aaccaagacg aacatagcga gcacaaagaa aaacagcgtg cgccaaataa 3527581 catttcgaat ggactttggc agtgtttttt ccgggctttc actttcccct gccgcaatgc 3527641 cgacaagctc cgttccctgg aacgagaagt ttaccatgac cagcgtaaac ataacggcca 3527701 gcaccccatt agggaaaagc cctctatcag tcataaagtt agacaaaaag ggtgtctcct 3527761 gtccgccttt aaagtcaatc aagccaaaca cagcggctcc gccaatcaca ataaataata 3527821 tgatcgccgc cactttgatg cttgaaaacc aaaattccat ttccgcaaag cttctgacag 3527881 agagcgcatt aatcaaaaag atgacgatgc cgaacacgag gcaccatatc cagatcggaa 3527941 cggagggcag ccacctttgc atcaaaatgc ctgctgacgt cagctctaac cctactgtat 3528001 tggcccagct gaaccaatac agccagccaa tcataaagcc tgtcgactgt cccagaaatt 3528061 tagtggcgta ggcctgaaac gatccggcca ccggcatggc aacagccaat tctcctaaac 3528121 aaagcatgac gagatacatt aaaaatccgc cgatgatata cgcggcaatg gcgccgagcg 3528181 gtcccgcctg gctaatggta aagccagagc ctagaaacag cccagtgcca atcacccctc 3528241 ccaaagcaat cataaacaaa tgcctgcttt tcatgctgcg ctgcaattca tttttatgat 3528301 tctgcatcat ccttccccct ttggttcttt tgccgtgatg gtcatccggt agctttgcaa 3528361 aagatgaacg gtggtttgct gtatgaggag aggcaataca tgaaatgtgt acggtttata 3528421 gactcgttct gtccatttat ggccgtcttt tccgtacacg cccatattaa tggatggaat 3528481 attcagcttg cgtatgtctt tgaacggaat ggtcccaatc atattccacc cagggaagtt 3528541 cctgataaaa gaatcaattt cgccatcggt ttcgtgcagt gataaaaaac tgccgtctgc 3528601 caagtagggg aaaaactttt tgaagacaaa tgtttcgcct gtcgattcag cggttttgtc 3528661 agccgcttct ttaatcacat gctgcaaaag ctgatctctt gcgctatctt ctttcaaata 3528721 gttatgcggc aggtaaggag gtgcgtaaaa tagaatgact tttgcgcctt gatcggggtc 3528781 aagcttttga agctcttcga ttgcctgaaa gcatctcatg cgaagttcaa ggtgctcgtt 3528841 ggctttgaat gtctgctcga tacactgctc gggatctatt ccccggtttc tcagcttttc 3528901 taagtattgc tccaggctat acacttgaat gccccatgat aaatgtttct ttggcaggtt 3528961 ggctcttttt acatattctt cgtaataatc tgataatttt tgttctgtct cccggcatgc 3529021 ttcctcagtg acttcaataa gcaaatccat catttctttt gctgttcttt cataaataaa 3529081 acaattgaaa tacaagctgg tgctgacagc cgtttgcaca ttataggatt ccttgttatc 3529141 acgctgatac aaacaggatg ggggcagaac caactcccct tcaacctttt ctgccagatg 3529201 gatgttattg tggagacggc ttgtgatttc agatgaaatg aaatttgggt caatccctgc 3529261 cagtgtatcg ccaacatgga cttcacgccc gtaaatgtaa aagcaaggca acagttttcc 3529321 cgcggctccg gtatagatat atcttgtctg atcaccatcg taaagcgggg taataaaatc 3529381 cgtattaata gcagccaaat agtgaagctg tttttctttt tttagccggt tcagctctga 3529441 aatgctggcg agaatgcccg aatgctggct ctcctcatcg ggattggcca taaacaatac 3529501 atttcccggc aacgtctcaa ggttctccga aaaatgcagg agattggcta aatgcacggc 3529561 gatgccgctt tgcatatcga cagatcctct tccgaacatc cactcgcctg atttggcatc 3529621 ccgctgaaca tcctgatcga actcatagcg gctgaaatac tcggccaatt tctcacaatc 3529681 aaaagcgata tcctttaaag ggccgaaatc ttcaattcca actgtatcca gatgggcatg 3529741 gtaaatgact gtatttcggc tttctccatg tcctttaata aacgcaaaaa tatttttgcg 3529801 tttgtatggg tcattgggaa tggcctgttc ccacacatga ctggggtttt cctgaaaata 3529861 aggatagctc gtgatcactt ctttgatgaa atctgctttt gtcccttctc caacggtgcc 3529921 gttcacgctg ctgaggctga ccagagatgc tgtcagcgcc tccactcttt cagccggatt 3529981 catgtgactg atttttgtat actgcataaa ttgtcctcct gatcaaaaag ttgaaatcgt 3530041 gcgatccgct aaagaatcgc acgattttat ttctctcaaa tcaaaaagct tcggacgttg 3530101 ttttggcttg catatgaaga attaagtaat cgggaccgcc tgcttttgag tctgttcctg 3530161 acatattaaa accgccgaac ggctgatagc cgacaattgc tccggtacat cctctgttaa 3530221 aatataggtt tccgacatgg aaatcctcgc gcgcccgttc aatgtgcgca cggtttttcg 3530281 tcagaagcgc acctgttaat ccgtattccg tgttattggc aatctccagc atatgatcga 3530341 aatcacgcgc tttgcaaatc gcaacaaccg ggccgaaaat ttcttcctgc atcaagcggg 3530401 cgttttcatc aacatctgca aagatcgtcg gctgaataaa gtagcctttt gaatcatcgc 3530461 cttctccgcc ggccaatagc ttgccttcag atttgccgat ttcaatgtat ttcatcactt 3530521 tgttgtagga tgcttcatga atcacgggac ccatatacgt atcaggatct tctggattgc 3530581 cgacagtcag cgttttggtc agcgccacag ctttttccac cacttcatca tacacatcct 3530641 gatgaatgac cgcgcgggag cccgcagaac acttctgtcc tgaatatcca aatgctgaat 3530701 acacgataga ggatgcagca aggtcaagat cagcgtcctt gtcgacaagc actgtgtctt 3530761 ttccgcccat ttctgcaatt acccgtttga gccatttttg gcccggctgc actttggcag 3530821 ctcgctcata aatccggcag ccgactgcac gggaacctgt aaatgagaca aaccgtgtct 3530881 tcggatgctc aactaagaaa tcaccgatct ccgcaccatc tcccggaatg taattcagaa 3530941 cgccgtttgg cagacccgct tcctccatga cctcgacaaa ttttgctgcc actaccgggg 3531001 ctgcgtcagc cggttttaag agaatcgtat ttcctgtcac aatcgctgcc accgctgttc 3531061 ccgccataat cgcgagcggg aagttaaatg gagaaatgac gatgccgacg ccaagcgctt 3531121 cgtaatgata ttgattgacc tcgccagcac ggctcttcac cggagcccct tccttgagct 3531181 ttaacatttg gcgcgcgtag aactctaaaa agtctatcgc ttcagccgtg tccgcatctg 3531241 cttccttcca cggttttcct gcttccttca caagatagct tgaaaattca tgctttcttc 3531301 tgcgcaaaat agccgctgcc ttaaagagaa tatttgcgcg gtgctccggt ctttgttttt 3531361 tccaggaatc aaatgcctgc aatgcggctt gcatcgcttt ttcagcaagc tcttgatccg 3531421 ctgtagacgc gtacccaatg atctcttctt tatttgccgg gttaatagaa atgattttgc 3531481 ggtccgtttc aattttttct ccatttatga caagcggata atgcttgccg agctgagtgt 3531541 ttacaaaggc caatgactcc ccaaatgcag ttttattctt tgcttccgta aaatcggtaa 3531601 atggttcgtg cgcgtatgtg actgtcatat gtagtccccc tcgtgttatg aaatatatct 3531661 tcgcatatga ataaaaatgc aagaatcatg ccattttctt gtcttttgct gaaaaaactt 3531721 gttgaatcga acagaaattt gtctaacagg tgatcacctt tctctttttc cgatcttgaa 3531781 cgcaaattta ttttgcgttt tttgctcttt acgcaaaaaa caaatgcaaa attattttgc 3531841 ggaggcttct caaattagac ccatccgcgg aaacgcgatg cttctgccga ttttctgatg 3531901 cccgtcatgt aagccgccaa acgcatatcc actttatgtg ttgccgctgt ttgataaatt 3531961 gtttcgaacg agctgaccat gacgcttctc agtttttctg caacctcttc ttccgaccaa 3532021 taatatcctt ggttgttttg cacccattca aaataagaaa ccgtgacgcc gccggcactc 3532081 gctaggatat ccggcacaag cagcacgcct ctttcattca ggatcttagt ggcatcaatg 3532141 gttgtcgggc cgttcgccgc ttcaacgacg attgacgcct gaatgttatg tgcgtttttg 3532201 gctgtgattt gattggagat cgcggcaggc actaaaatat cgcaatcctt ttcaagcagc 3532261 tcctcatttg tgatgacgtc agtaaataaa ttggtgacca taccaaagct gtcccgttta 3532321 tcgagcaaat aagggatatc aaggccgtct gggttgtaga gcccgccatt ggcatcagaa 3532381 atcccgatca ccttcgcgcc cgcatcgtgc atgaatttgg ccaggaagct acccgcgttt 3532441 ccaaagccct gtatgatgat gcgcgcgttt tgcagcttga tccctttttt cttcaccgcc 3532501 tcttcaatac aaatcgtgac gccctgtgcc gtcgctgttt cccgtccttg cgatcctccc 3532561 aaaacaagcg gtttacctgt aataaagccc ggagaatcga attcccgcag ccggctgtac 3532621 tcatccatca tccacgccat aatctgcgaa ttggtgtaca catcgggagc tggaatatcc 3532681 tttgtcggac cgacgatctg gctgatggca cggacatacc ccctgctcag cctttccagt 3532741 tctccaaatg acattgtccg cggatcacaa ataataccgc ccttcccgcc gccgtaagga 3532801 agattggcaa tcccgcattt gagcgtcatc caaatggata atgcctttac ttcctcttca 3532861 ttaacttctg gatggaagcg aacgcccccc tttgtcggac cgacagcatc attgtgctgt 3532921 gaccggtagc ctgtgaacac tttgacgctc ccattgtcca ttttgaccgg aatgcggaca 3532981 gtgagcattc tctgcggctc tttcatgagt tcatacatat ctcccggata acccagcttc 3533041 cgaagggctt ccttaatgat tgtttgggta gacagaaata agttaagagc ttctttttct 3533101 tcatctttcg agacttgctt tgctgacatc tttttcacct cattgttttt ttggccggct 3533161 gtaatgtaag cgctttaaaa aatcagcccg ccaattcctt tcttcattgg attcaccctt 3533221 atcatcatgc aagatccgta ccagcttttg aatccacaaa aaaagagact gaaaacatct 3533281 cagtctctga ctacaaatct atcgattaac ggggatcaat caccagctgc gtttcagcat 3533341 aaaaactgcc gattcccaaa ccgtttacta catcgccttt aatcgtgtaa gtgcctgcgc 3533401 gaggaagagt tttacgcacc atgacaaggt caaattcgga tgcgcctaac aaatcaagcg 3533461 taagcgggag tctgactgtt tttccatcgt ttaaaatctg tgtttctttc agtgttcttc 3533521 cattcactga atctcttgtc gtagcatgaa acccgtcagg aaattgaaat tctaccgctc 3533581 caagagaaag caccgcattt ggtttatatg tcacttcaat atcagaaatg gtccactctt 3533641 tcgtgctgtt aactgttttt gcctcgattg atgcagactg tgcatgagct tggcccgaag 3533701 gaagtaagat tgatagtaaa acagctgaac tgatgaataa tgaagatacg aatgaagttc 3533761 tttttagcat gacatttccc cctaattgat tgttgaaatt tggccagagc gtcctctgca 3533821 gaaaaagcgc tttttcataa ttcgcgaatt accagttctt tttcttaaaa attaatctat 3533881 catcattttc catggaagta aatgtttttt aaggaatatt aacacttgga attcaatgag 3533941 aattccttcc tgtttataca aggttcaaat ggacgatttc cctctctttt tctagtaaca 3534001 tctgcctgac attttatatc ttttatccta ttttaaaaaa gggcaaaaaa agtcgaagat 3534061 gcctctgctc ttcgattgat cacgttccta tttttatctg aattcagtgt tccagttaaa 3534121 accgatcgtc tcatcatccc acggaattct tttttcatca ggctgatccg ggttatacga 3534181 catggtggta aaatagataa ttgtcagcgg cgtctctccc agcactctat atccgtgagc 3534241 cacccctttt gggattaata acagcatcgg gttgtcttcg cccatataat agacgtccgt 3534301 ttctcctttt gtctttgaat cctctcgaag atcgtatagg acaacctgag cgtggccggt 3534361 tgggaagaac cagagatcat cctgcttctc atgataatga aatgccttaa tcacacccgg 3534421 atagcttttc gaccaagagg cctgcccaaa atgctcaagg agattctcat cgtcccggac 3534481 cagctcagca aaaaagcctc tgtcatcgct atgcttcatc aattttttca ccttgactcc 3534541 atcaatcaca cgcactgctc ctttcctgca aatactctcg taacgcttcc cgccagtggc 3534601 gggggcggat gccggcttct tcaatagccc gatggctcag cacagagtat gccggacggg 3534661 gcgttttgtt cccgtattcc tctgtcgtta cagacaaaat ggctgtttcc agcccgcttt 3534721 cttccataat tgccgtcgca aactcatacc agctgcatat gcctgaattg ctgacatgat 3534781 agatgcccgg cggatggctg aacagcttga tgaccgcttc tgctaaatcc ttcgtataag 3534841 tcggcgaacc aatttgatcg ctgacaaccc gaagctcttg tttcgtttca gcaagtttca 3534901 gcatggtttc aacgaaatta ctgccgccat gtccgtacac ccacgatgtc ctgatgatcg 3534961 tgctgtcttt tgtcgttaat cgtatcagtt cttctccgag ccttttgctt ttgccataaa 3535021 tggttttcgg atcgagggga tcgtcttccc tatatggctg ggttcctttc ccattgaata 3535081 catagtccgt gctgatatga acatattgag ctccgatgcg ggttgactca agcgctgtat 3535141 aataagcgcc gattccgtta atcaagtacg ctttatcaag ctctttctcg cattgatcaa 3535201 ccgacgtaaa cgcggcgcta ttgaccacga tatccggctg ataatggcca aacgaatgcc 3535261 gtactgagcg ctggtcagca atgttcatca tcttctttgt taacgcaatg acctcatatc 3535321 cggcttgctt cagctggcgg catagttcca agccaagctg tcctcccgcc ccagtcacca 3535381 atacctttgt caatcagatc accttctcat cggtcattgt ctgtatacca ctgaatcgta 3535441 cgcgcaatgc cttcttcaaa cgtcacttcc tgccgccagc ccagttcgtt tttcagcttt 3535501 gatgcattga tcgcatagcg ccggtcatgc ccttttcggt cttccacgtg ggcgaacaat 3535561 tcctcacagc ccagatgctt caaaatgaca ctcgccagct ctttattcgt gcgttcattt 3535621 ccgccgccga tgttatacac ctcgccgtcg gtcccttttt ctaaaatcag cttgatcgcg 3535681 cggcaatgat cctccgcaaa cagccagtct cggatctgga gtccatcgcc atacagcgga 3535741 acaggcaggc cctgcttcgc atgacggata atcgtcggaa tcattttttc gctgtgctga 3535801 taaggtccgt aattgttgct gcatcgtgta atgatggccg gaagcttgtg ggttttcaca 3535861 taagacaaca cgagcaaatc agagcttgct ttgctggctg agtatgggtt attaggagaa 3535921 agcggcgtcg tttctgtaaa cgcgggatca tccgctttta aatccccgta tacctcatct 3535981 gttgaaatat gaatcagctt cttggctttt cctttcaaga ccgcttccgc caatcggtat 3536041 gtccccatga catttgtggt gataaacggc tccgcttggg aaatgcttct gtccacatgc 3536101 gattctgctg cgaagtgaat gacgccatcg taggtctcgt caaaagcgcg gtcgatatcc 3536161 tcctgaacgc tgatgtcccc ttttacaaag cgaaaacggc tgttttgctt taatttttcc 3536221 atttcctccg ggtggctggc gtacgtcagt ttatctaaaa cggtaatgcg cgcatccgtt 3536281 tccctcagca tgagctttgt aaacgtgagc ccgatgaagc cggccccgcc tgtaattaaa 3536341 tatgattttg ccatcacttt tcgtcctgtc ctttccgtaa agcctggtgt acaagctggg 3536401 aagcgagata aagcgattcg tgagttccgg catctaccca ccagcctgat aacacatcat 3536461 acgtaagctg gctgttttcg atgtatagat tattcacatc ggtgatttcc agctcgccgc 3536521 gctttgatgg tgatatttgt tcaatatatg aaaacacctc tgcatcatac atataaatgc 3536581 cggtaacaca aaggttggtc ggtggctgtt cgggcttttc gatgatggaa cgaatccgct 3536641 tgtttttctc atcaatctca gcaatcccga aacgttccgg gtcatcaact tctttcagaa 3536701 gcacttttgc tcctttcccc tgctgttcaa agcgttctgt ataaggcttt aatgaatctt 3536761 caaatatatt atcacctaat aataaaatga aagactcttt tttcgtaaag cgctttgcat 3536821 aagacagccc atccgaaatg cccgatgctg ccggctgtac ttgataagtg atagtaacgc 3536881 caagctcttc cccgttccca agcagtttgt aaaattgcgg catatgctcc ttttggctga 3536941 tgagtaaaat gtcttttatt ccggcttcct gcagcttcat aatcgaccag tatatcatcg 3537001 gatacgggcc tacaggaagc aaatgcttgt tgacggcttt cgttaagggc ataaggcgtg 3537061 agccgtttcc tccggctaaa ataacacctt tcacattaac acttccttac atgcattttt 3537121 atatctcttg ttcatataaa tcttgaagaa tagctgttac ccgtataatg cctttgccat 3537181 ccacgagcgg ccttcctccc ttgtgcaaag aaaggcgaag aggatagctg ctcataatgc 3537241 gtgacatctg atagatgagt gtttcatccg gtacaagctc acccaatcca agatcaagag 3537301 cggcgccttg gtcagcaaat gttttggctg tagccgtttg atgctcaacc tgagaaagaa 3537361 caaggcacgg cacgccgatg caaatggctt catatagaga gatgccgcca gcgacaatgg 3537421 ctgcgtccgc ttgtttcatc aaacctgcca tatcatttgt ctgttcgatc atcttgtact 3537481 gcggcttctt ttcgatccgc cttcggactg cctcttgatg cggtgaagcg ctccccatca 3537541 caaacatcat gtttttgtct tttatgtcgg ggacttgatc agcggcagcc agcactttaa 3537601 aaataagctg cttcggatca cttcctccta atgcaacaag gatattgcgg cagtctttct 3537661 taagtgtgta atcctctctt gcggcctgaa aggcggggtg aagaataaga tagtccggac 3537721 cttcatagat gcgtgtgttt ccctgaacgt acaccctgct tctgatgtca ccgtaaattc 3537781 cgttaatgac tgcgtcacta tattgaatcg atttaccgtt tttctcttca aaaagaacaa 3537841 ttttcgcatc tgtctccgtc tttattttct ttaacagctc tgcaggcgcg cctagaatat 3537901 caaacaaaag caaatcaagc ttcttgcttt ttatttcccg gagaataaat tcgtgctgct 3537961 gcagctccgg ctttacgatg acctgccaat gctcttcatg aagaaacgct tcagaatcct 3538021 gattcgtata aaacgtaatc aagcatcgct gtttgagccc ctccgcaagc ctcttcatcc 3538081 ggacaacatg gcccattccc ttttcatagc cgccgtctgc gaagatccca acatgcatgg 3538141 ctagtcagcc tctcgttcgg ttgccgcatc ggggttccgg ttcagaaggg tgataagctc 3538201 tgaggcggat acatcggggc gctcgcctgc tttttgatag agggccttta tcgattcata 3538261 gtcttccttt gtatcaatgg tcagccgata ttgaggggcg cgaaatcgtt ccggcgcctc 3538321 taaaaactga acacgataaa gagctggatg attccttata tataacgtga catgctcctg 3538381 atattgatcc tccaaagcct gaatacggct gatgtcaatt aacaggttgg cgttgaccac 3538441 ttcgccgcaa atccctaatg gggcattcag gatatacgta taatccgagc cttgatcaaa 3538501 atgcgcctga atcattacat cgagcagctc aggatcgaca aacggattat cacctgttaa 3538561 ccggatgatg actgacggtt taacagcttc tatgaccttc acaaacctat cgaggacacg 3538621 ttcttcgctc ccgcggaaaa cacgaaagcc ttgtttgata cagtgcgcct ctaatatgtc 3538681 gtcagtttct ttgtcagacg tggcgatgac aagattatcc cgatcctttt ggtaaaacgc 3538741 gctttgccgg acacggtgaa cgagaatatc aagtaaacga ttcgatccga gcggccgaag 3538801 cacttttccc ggaagccttg ttgaacccat tcttgcttga atgataaaga gaatatcatt 3538861 catgaaacgg gctgtccttc agtaaaatgt catcccagac aatgcctgtg tcggctggaa 3538921 tgtctcttac agcccgaaca ccgctggtca gcagttcaaa aaatctcggg tgcagcccct 3538981 gcggcttttg tccgggccga agcactgcga tattgtcttc actaaaggct tcaccttttt 3539041 gaatcggagc tgttgtaaaa atgcctctgt atgcaaagtt tctgatttct ccttcgatgg 3539101 cggtcgttgt tttgtatgaa ctgccaagca gtttttcaga gaccggcttt gtgatcccct 3539161 gtttcagctc agcttccgtt ttcctgatgc catcgaccat ttctttcaat tcatccggat 3539221 ttaatgcaaa cgagtggtca gcacccggca gatttttatc gatcgtaaaa tgcttttcta 3539281 tcagttttgc tccgagccga accgcggcac acggcgcttc tgtcggatgc tcgctatgat 3539341 cggagaagcc gattaccgcc tcaggaaaag cggcggcaag catcggaatg acgctgaggt 3539401 tgctgtactc cggcggtgct gggtatttcg ccacacaatg cattatggca atttgattgt 3539461 ttccctctgc cctgatggtg cgccaagctt cgtgaacatc agagatttca gctccggctg 3539521 tcgagaaaat catcggcctg ttcagccggg cgacatattt aagcagcggg agatggttaa 3539581 tttcatagga tgcgatttta aaagcgctcg gcgaggtaga ctgaagcaga tcagctgacc 3539641 cctcgtcaca taccgtactt aaaaagatca cctgcttttc gcggcagtaa tccaatagcg 3539701 gtaaaatcca ctcagcaggc atttccatag attgaaccaa agaaaaaata gagacgtcct 3539761 tgcccgctgc cgtcttgtac aaaccaggat ctttctggta catcctatca gcttggaaca 3539821 tttgaaattt cacggcatcc gctcccgctt ccgccgcggc gtctatcagc gcaaaagcct 3539881 gatcaagctt cccgtcatga ttaatccccg cctcagcaat aataaaaaca ggagcgtctt 3539941 tgcctacagt tttattcgcg atctgaaacg ctgccattat ttcgcctcct tgcccggcca 3540001 aatatgataa tagtaatacg attgttcagc ggtgaagccc attcgttcat aaaggcggat 3540061 cgcccttaca ttgtgaagct gcgtccccgc tgttaccgtt ctatgcttct gggtctccgg 3540121 ttgttctatg agattcgcca ataaatgaaa cgcaatacgt ttcccttcaa atcccggctt 3540181 tacagccatc aaatcgagaa tgcactcatc atctcttgat aagccctgaa gatagccgat 3540241 gacctcgcca ttgtgtttag cgacaatatt gaccgccgcc cttccattca gattgtttcg 3540301 tgtccactcc tgaaatattt cgtttgctgc atcgcggctg agatgaggat cctgaaaata 3540361 tctgcttttt gtaaacgagt ctcgggccag ctcacatatc gcttctgtgt ctccgggctc 3540421 aggcgggccc agttcaaaaa atggcggtgt tttgtcataa aaagacggag gcatcgccag 3540481 cttcagcaaa ctcccgacaa agtaagagga tggctgctgt tgtatcacat gcgcggctcc 3540541 gatatcttca gccggaacac ggacaaagat aaaatccgtt tcatccattt ggcgtacagt 3540601 ataaaaagct tcaaacagcc tctttagctg cccggtacta tttgccgcaa gaagtttgac 3540661 gttcatgact ttcttctgaa gcaccttgct ttcccacaaa gaatcttcgt aaagcaatac 3540721 gccttggagc ctgctgtttt caaaaaggcc gagggaaaat tgatacggaa catccaatgt 3540781 aagctttctg ctttggagaa attcctcaat tgcctctttg gagacatttt cttttaccgt 3540841 atacacttaa tcagcccctt ttacgatatc ccgcacagct tcaatgacat catctacatc 3540901 atcgtcagac attgatggat agagcgggag agaaagggtt cgtttatagt aattcatggc 3540961 attcggaaag tccgcttcct tatatccaaa ttgcttttga taatacggat gaatgtgtac 3541021 tggaataaaa tgaacgctag tgccgatatt gtattcatcc tttaaagccg taatcatttc 3541081 gctgcgcgta accccggcct ttttttcatc aacttgcaga acatatagat gccaggcgtg 3541141 cctgccgtca tcatggacaa acggcgtgat cagcccagga atctgctgaa aagcggtttg 3541201 atagcggccg gcaatctctt ctctccgttt ctgcatatca tccagccgtt tcagctgatg 3541261 aagtccgagg gccgcctgca aatcaaacat attcatctta tagccgggcg attcgacttc 3541321 atagtaccag ctgccatttg aagaataacg gttccatgcg gctttactca tgccgtgaag 3541381 gcttagcacc cgtatcttat cggcaagctc ctcatcatca gtcgtcagca tgccgccttc 3541441 ccctgtcgcg aggtttttgg tggcgtaaaa gctgaatgcc gttgcatccc cgatagaacc 3541501 gatcattctt tgcttataag tcgtatatac cgcatgtgcc gcatcctcca gcacgaataa 3541561 accatgattt tgggcaacag ccaatattgc atccatatcg caggactgcc cgccaaagtg 3541621 gacgggcaca actgctttcg ttcgcggtgt gacggccgcc tcaagcttta ccgggtcaat 3541681 attgagcgtg ttttcgtcaa tatccgcaaa cacaggcgtc gctcccgtat gaataatcgt 3541741 attggcggtc gagctgaacg taagcggaga ggtaatgacc tcgtccccgg gcccaatccc 3541801 ttttgctttc aaagccaaaa ataaagctgc ggtacatgaa ttcaccgcca cggcgtgctt 3541861 cgccccgaca aacgcggcaa actctttttc aaactgctga accttcgggc ctttagagag 3541921 ccatcccgat tcaagcgttt ctgtaacctc ctgaatttct tccttaccga ttaacggcaa 3541981 tgagtaaggg agaaaatgat ttctcttttg caccatttct ttgcgctcct atcattttat 3542041 tcagtatctt cccgcctgta atcaacccct gttttggctt tcagttccgc aaataaagca 3542101 tttgttgatt ctgccaccgg ataattagcc gctatgaatg ccaggcgcgc ctcttctgct 3542161 ttttgatgca cgtcgggact tcgaagaacc tcaaccaagg tgtgcgccag ttcatccggc 3542221 tggtcaaaca taaaatcgcc aagagactca taatacggat acgagcgatt tccggacgat 3542281 tttcctatca gcacaggctt ttgaaacagc atggcttcaa gaccgactgt cgaggtttgc 3542341 gtcactgcgg catcaacata cggcagcaaa tcataaagct ccagctcctt tttgatgact 3542401 ctgcatgctt gatgtttttt cgccgcctcg tgatacagat caagcttgtt ttttccgatt 3542461 tcccacgggt ggggtttgat aatgatttgc agctgcttct gatcagaaag cccctgcagc 3542521 acaccggaat aaaagtcttc tgaaaagggc tgagtggcaa tgagcacaat ttttttagtc 3542581 ggctgaaaag caagttttcg atagaatatg gacatatcca taggcgttct gttaaaaatc 3542641 tgatcgaagc ggggatgtcc cgttacgaga atctgctcgg gtttacagcc ttttcgtatg 3542701 aaccactctg cttcatacgc accaaaaaca gcttgatagg ttgtaaaaac aggaatgaag 3542761 gcttcatctc ccatcaatgc gccatgctga agacaaatgc tgacggcccc ttttctttga 3542821 cacatgagag cgagcaccct gctgtaaatg tcttctgccg ttccgacaat aacagctgaa 3542881 atcttttcct gttcaaacag cgcatcaact gtatcaatgg cctctataaa taaaggaata 3542941 tctttgaaaa gccggtcgcg aaacgcttga tcaccaaatg ccgggtgatc atcataaggg 3543001 gcgagaagcg aacaggctgt ttcgagatac tgcttcgaat cgcctttttg gcatgaatcc 3543061 gcaatctccc gcttgctaat tacaggcaga tcacaataat gcggcaaact ccatctggcc 3543121 aaaacagccg ttttttcagg atcaaattga tagtaatttt cgtttgaaaa acgcaggtaa 3543181 tcaaagtgca aaatgacttt ccctttaaca ggttcgtcat ttgttttaac gatgttttgg 3543241 attctttctt caaaaaacgg ctgaatctgt ccctcatcga tatgctgatc caccgatccg 3543301 aataattccg gttcttcttc catcatcacc ctcagttcag ggctgatgta ttgataaaaa 3543361 ttactgataa gcccaagcgg aatccctttg tagcgaagtt tgtcaaaaag ctccacgtac 3543421 ttccggtaca gcacccaata attgcttaaa taggccgaca agctctcacc ccattccaag 3543481 cttttttaat gattcacgca gctctcggca atttcgctgc ggaggaaggt tcctgacaaa 3543541 ttcatttttt tctaattcaa acagctgaaa gtgaatcgat tggtcggtaa tataattcag 3543601 gtccagctcc tcatccagtg ggtaaaacgg ataaaaatga ttgactctcc aaaagaaccg 3543661 ggcatctcct atacggtaaa acgccgggct ttcatcccaa taggagccaa acttctcctt 3543721 taccttctca agcaccgaat acctgtgcat caccgagcaa tgatcaattg cgcacggcgc 3543781 gttccatgtc acttgagcgg caggcctgac agtttctttt acaatgtcac gattctcgtt 3543841 taaatgatag gttttggagg ctgagtaaat cacagccttt tcaggatggg tatcgagctc 3543901 ccgcaccatt ttcaggaggc ggtccggcat atagatgttg tcatccgtcg cataggtgat 3543961 atattcaccc tccgccatct caatcgcctg attgatcagt gccgcgtatc tcgttttttc 3544021 tgttctttcc ttcactccag atatatcgct ttgataaaaa cgcactcggt tatcattcaa 3544081 aaaaggacgg attacattca gcgtctcttc attggagttg tcatccataa taaacaattc 3544141 aaaatctgaa aacgtttgtg agagtatgct agaaatggac tttgccacat aatcgctttt 3544201 gttatagctc gtcataatga ctgatacttt aggcaaatcc tacacctcct tcttggaact 3544261 tcacacctga aactatcgtt atcttatgtt gcttatgctc aagttgcgct agggatacaa 3544321 accaatatgc gaaaagtttg tgtatgtttc tgaaaaacag cggctgccca gagcgaaatc 3544381 tgatcggtcc gctgttcttt ttcagcataa tccaagcatc agcctcataa ggtgaaagag 3544441 ataaaaatcg caccagcgac taagatcgtt ttccatcgga ggtgagtcat cgcggagcgt 3544501 tcacctatac atccagaaca tgttttgaat ggttttcata aaaaggagga acgatatgaa 3544561 accgaaaaaa aatcaatatc agcaaatgca ggcatttgat aatatgcagg ggtatcagcc 3544621 tcagtttggc gccaacccgt acccgcagca aggccaaggc tcacaaatgc agacaatggg 3544681 gatgcagcca atgatgccaa tgcagcaggg acagcaagga caacaaggac agcagggatt 3544741 tggattcccg ggccagcagc agggcggcgg ttttcaaatt ccatcggggc ctacaccgtc 3544801 aggaccgggc caaagcgttc ccggcatgct gcctgttgag gaatcttaca tcgagaatat 3544861 tttgcgcctg aatcggggaa aaacggccac catttatatg acatttgaaa acagcaagga 3544921 atggggctcg aagatttttc gcggcgtcat cgaagctgcg ggccgggatc acattattat 3544981 cagcgacccg aaatcaggaa cacgctacct gctcctgaca atctacctcg attacattac 3545041 atttgatgaa gaaattgctt atacgtatcc atattccatg gcgtcctatt cgccaagata 3545101 agaaaaaagc caatcactca tatgatgagg attggctttt ttgtttatag atatttgacg 3545161 gctgcgacaa cgatcataat ccaagaaata ataaacgcca caccgccgag cggggtgatc 3545221 gctccaagaa tggagatttg cgtcacactt agaatatata agcttccgga aaacagcaca 3545281 attcccgcaa acatcagcca gccggctgtc gtgacactgc ctatgccgga taatttatca 3545341 gccagaaacg cgacaacgaa taacccaagg gcgtgataca tatgatactg cacgcctgtg 3545401 tgccaaacct gaagatactt atcaggtatt ttcccttcta atccgtgagc gccgaatgct 3545461 ccgagtccca cggcaagcag ggcgttaatg gcccctaata tgataaaaac tttcatctat 3545521 ctctcccgcc ttttcgttaa actcatatca tttatcttat cgcacctgca ccaaaattca 3545581 atgtttgttc tccgttgaca cgagattgtc ggattttctc ctgcgccaaa gctggaactg 3545641 gtcagctgct attgcagcaa gcgtccctaa tacgagcccg ttgcttaata gagaaataaa 3545701 taccggatgc aatcccttta acgcagtttc aggaacaaac atgataccga cccctgtcag 3545761 cagtgagata ccgatgatag acctcaccct ttttgattct tctttctcat atgaatcaaa 3545821 ttcggcaaag gccagaccgc ccattgcgga gaacacaaca aaattcaccg caaatccaac 3545881 gggtgacggc aggctcgcaa acgtattcat aaaaaacggg atcacgctga tcacgataac 3545941 cagaatactg ccgagcataa acggtttttt agaaggcatc ttggtcgttt caataaaacc 3546001 tgcggctccc gaaatcggaa caggcgcaat agctcccgtc aaaccgctaa gcagatggct 3546061 gaatgaagct gcaaaaccgg catggcgttc atgatgcttt ccatcaggct gtttgctgaa 3546121 ttttttcatg gcgatgtcca cgaccttcat gctcgccagc atattcacga tcagcaagat 3546181 ggtaataaaa atagaagtga tgatcaggcc gctgttaaat aacggggtcc caaaaggaaa 3546241 cagggaaggc agctgaaaca gccggtccgg catttcaatc ggctttgcgg ctccggcagc 3546301 cgcaaacagc acccacccgc cgaacaaggc taataaaata gaatattgct taaaaaacat 3546361 gatgttcgaa tttgtcatta taaaagcggc agcgatcaca acaagcgcca ggccaaatac 3546421 aagaccgtcc accccgtcct gtcgataacc gattccgaga attcctttta taatgggctg 3546481 actcagctgc atgacaagaa gcaataaata gacgcccgtt acaaccggag taaacaattt 3546541 tgcaagtctg tcaatgacct tgaaaacact taacaaaaag aaacatacag cgcttacaag 3546601 aagagctccc tgcaaacccc gcagtgtgtc tccatatgtc gcaaacacag ttcccgtcag 3546661 ccctgcgtaa atcgtataca ctccccacca caagccggct gggctttcat tgatcggcag 3546721 tctgtggcct ttcaaacact gaatgacggc ggcaattccc agtacaaaaa aagtgctttg 3546781 aatcaatctt gcagaatctg agtgatccag atgaaacgac tgggcaaccg ccaccggaac 3546841 aacaatcgcc gcagcaataa taaacgctgt ccattgcagc gcgccaagaa ccaatttcac 3546901 gtaagctcaa cctctctctt taaaaatcaa ataaagactc tccgtttcca tcctcttcct 3546961 gcttctcttt ttcttgcttt cgatatttgt ttaatcccgc gctccccatc attttttcca 3547021 tcatcagctg gtctgtcgat ggcggcgcgg cgggacttgg cgtaacgctc ggctgtatgc 3547081 ggggcgcgct cgcgttctcc ggctgatcaa gcacgacatc acacagagaa cggacaaccg 3547141 ctacataacg cttcagctcc tcatcccgtt cagccgtttt tgcttttttt agctcttctt 3547201 ccatcttttg aatcaaagca gatatatgaa tgttcatgaa gcaccctcca aaaaaataaa 3547261 tgttgtcttc ctgcatttta tcaaattcct gctgaaaacg cagatatgag tttgttattt 3547321 tttctgacaa accttgcgcg attgacaagc agaagagatt tttcacataa taaatcacca 3547381 taccttacaa aaaggagaaa cggaatgaac agcatcccct ctatcatcag caagcataaa 3547441 gcctattttg cggcgggaca tacgagaccg cttgaatcga gactgaacat tttgcgaaag 3547501 ctgaaacaag ccgtcagaac tcatgaagcc gatctcatag ccgctctcta ccaggatctc 3547561 cataaatccg agcaagaagc atactcaaca gaaatcggaa tcgtcttgga ggaaatcagc 3547621 tttgtcatga aacggctgag aaaatggtcc aagccgaaac gagtcaaaac gccgttgact 3547681 catctaggct ccaaaagcat catcatccct gagccgtatg gaaccgtttt ggtgattgcg 3547741 ccttggaact atcccttgca gctggcgctt tctccgttga ttggcgccat tgcggcgggg 3547801 aacacggtcg ttctcaagcc atcagaatat acgccggctg tttctgctat tctttccaaa 3547861 ctcatcagca gcgtttttcc aactgattat gtcgctatgg cagaaggcgg gcccgatgtc 3547921 agcacagcat tattacagca gccctttgac tacattttct ttaccggcag tgtagctgta 3547981 ggaaaaatcg tcatggaggc cgccgccaaa caattaattc ccgtaacctt ggagctcggc 3548041 ggcaaaagtc cctgcatcgt ccataaagat gctgacattc agcttgccgc caaacgcatc 3548101 gtcttcggga aatttacaaa tgcgggacaa acctgcatcg caccggatta tttatttgtc 3548161 cacgaggaca tcaaaacgaa gctcacagaa gaaatgaagc gtgcgatcag agaattttac 3548221 ggccctcagc cggaacggaa tccacagtac ggcaaaatcg tcagtgagcg ccactatcag 3548281 cggctgctca gctttctgaa tgatggcatc ccgctcacag gcggacaatc tgatcccaat 3548341 catcacaaaa ttgcgccgac cattctcgaa caagtgagag atgactctcc agtgatgcag 3548401 gaggagattt tcgggccgat tcttccgctc tttacatacc gcaatatcgg ggaagtcatt 3548461 gagaaagtcc aatcgcgccc taagccgctc gccctgtatc tcttcaccac aaacaaagaa 3548521 attgagcgcg ctgttttagg aaatctgtcg tttggcgggg gctgtgtcaa tgatacgtta 3548581 atgcatgttg cgacgccgta tttgccattc ggcggcgtcg gggaaagcgg catcggcagc 3548641 tatcacgggt ttgacagttt taacacattc acgcacaaaa aaagcgtcgt caaacaaacg 3548701 aaccgtttcg acttcgcatt tcgttatcct tcctccaaaa acgggctgcg aatgattcga 3548761 aaaatactca aataaaaaag cgcagatcac ctgcgctttt tacaaatcct taatacacca 3548821 atcaatcggc gcctctccca ttttctccaa ataggcattc gcccgggaaa acggtctgct 3548881 cccgaaaaat ccgtttctcg cagaaaacgg gctgggatgc gtcgattcaa tgataaaatg 3548941 cttggaggtg tcgatccgtt cttttttcat ttgagcatgc cgtccccaca aaataaagat 3549001 aaccggccgc tctctttcac tcagcacgtc aataattcgg tccgtcagtc gctcccagcc 3549061 ttttccctta tgggaattcg cctgtccgcg ccttactgtc agcacagtat tcagcaaaag 3549121 aacgccttgc tttgcccagc tcacaagcga cccgtgattc gggatgctgc acccgatgtc 3549181 ctgctgcagc tcaagaaaga tattttttaa cgaaggcggc tgctttacac cgggcttgac 3549241 agagaagctt aaaccttgag cctgtcccgg cccgtgatac ggatcttgac ccaaaatgac 3549301 gaccttgaca tcatcatatg atgtataatg cagcgcgttg aaaatatccc ggctgtccgg 3549361 ataaatcgtt tgctccgcgt attccctctt cagcatctct ctgagctctt gataatacgg 3549421 tttctcaaac tcttccttta gctgattcca ccagctgtct tgtaaaagct gtttcaagat 3549481 tcaggcctcc ttacgaacga tgaagtctgg aatagacagg ctcgccatcc caaaccattt 3549541 cactttttgc ttcccgcctc ttcatctcag gctcttcaag caggacggca aagtttttcg 3549601 tcggcagctc cccgagtccg tgcttttcac ttaaacgatc caaatattgc ttccgcttgg 3549661 cgccaaggtc agcagactga ttgtctcccg cgtcactgaa ggcataaatc acgctggcgc 3549721 aagggacacg cttcacccgg taatccttgg ccgcgcgcaa ataaaaatcc cagtcccagt 3549781 aattgtgcac atcagcatcg aaatacccga tttcatcatg cagaaaacgt ctgtacatgc 3549841 tgcccgacgg cacgtatgta gaaaacactc tcatatcctc atagtcagcg gtataagcaa 3549901 acaatttccg tgacactgga taccttgttc cgtttttctc ttcaaacgaa actatttccg 3549961 catcagaatg aacgaagtct gccgtttcta tttcctttgc cattttctcg atatgccctg 3550021 gcgtaaagaa atcatcgtca tcacacagca taatgcaatc cccagacgcc tcttttacac 3550081 cggcatttct cgcagccaca tgccccgagt tcttttctaa attgatgaca gcaatcggca 3550141 gctccggata aagtgctttg accggcacga ccgattcccc ggcatcattc acaataataa 3550201 tttcatacgg catcaaggtc tggcgggaaa tcgactccaa aagctcacac aaagccggaa 3550261 tccgattata ggtcacaatt acgatagaaa tcttcatgat gctctccttc tcattttcat 3550321 agtcatgtac tattaaaaca tatattggac gggagatcag tgggaatatc ctactgaaac 3550381 ggcatactac aatgatagaa acagcaaagt ggctccgatc agaagcacca tgatcagcat 3550441 cagatctcca aagacatgaa agatatcttt catgcggacg ccattcggaa ggataagacg 3550501 ccacagctta gattgataga ccggcagcag caccagtgca taagaaagac acaaaaatgt 3550561 aaaagccggc ggcacaaaag cacagcctgc atcgtcccaa ttcatcatga tgtctttcat 3550621 actagatcca tccaataaaa acaaagatat catgagggct agcaacacaa aggaccccaa 3550681 ttgaacctca aacaggcgca ttttctggtt atatgcaaat cggaccgccc aaaaccagac 3550741 ataagcatat gaacatagca gcgtaagaat ggcacctgct gtaaagacga catcaggcag 3550801 ccgatcaagc agaaaaacaa aaggcaagct ggctgccata gccaagagca tgcagccacc 3550861 agtaaacaaa aatactgccc catgagctac aaaaccatat aaacaagagc taatcctcac 3550921 gacatacacc tcctttacat agaaattcta tgtatatacc taaaaaatca gacaagctga 3550981 cgcctgccaa tataacagcc cattcggcca aataacggaa ataacagcgt tgcaaaagca 3551041 caagttccaa caaaccaagg tgtcaacaag gattgaaaca gcgcagcagg aattacattg 3551101 aatagaaaaa caagcataaa aatgacgttt ggcaccattg agatcagaat cgtatgtaga 3551161 acaagctttt ctccgcgttt tccaaactcc ttcacgcctt gatacccaat cagcacccag 3551221 tagatcatat atgcagctaa gatcagccaa acagaaacag aaatgccttt ccatactgct 3551281 tgaacaaacg gtgattcaag ccatacatgc attattgtaa tcgcaatgcc gacagcgaat 3551341 agggcactgt tacagaaaag atggaacatc aaaaacgcac gaaacgttac tggctgtatt 3551401 ttcttaaacg aagaaacaat gtcagttggt gttccaaacg cctgcaataa agtctgcata 3551461 gcttcctcct cactctttcc ttcctgaaaa gagcgaaaca gatgatgttc aatatggctc 3551521 tcaatctctt ctatcatcgc ctcaccctca ggaagccctt taagcccgct tttgatttcg 3551581 gatacatatg tttctttatc cattttgtcc gctccacttc agtattcggt ccatcatggc 3551641 tgaaaatacg ctccattcct tcgtgcgttc cgccagcact tctttgccct cgtctgtaat 3551701 ccggtaatat ttgcggtccg gtcctttctc ctgcttctcc cagtaggaag aaatataccc 3551761 ttggcgttca agcttgtgaa gagaaggata caaggtccct tctttcatct gcagttcatt 3551821 tccgctgcgg cttcccattt cttttacaag ctcatagccg tacatcggcc gctcgttcag 3551881 aagcgtcaat accaatataa ccgtgcttcc cttaaccagc tcacgattta acatctcaaa 3551941 acccctacct agttttctta tgtagcattt tacgaaagcc cgttgagatt gtcaaatgat 3552001 tcctatagat cttctatatt gtgatacaga gaaaatctaa ctataatgaa agacaaaaca 3552061 tgatggaggt tcaagacatg tctatgcata aagcactcac cattgccggc tcagattcca 3552121 gcggcggtgc tgggattcaa gctgatttaa aaacatttca agaaaaaaac gtatacggga 3552181 tgaccgcctt aacggtgatc gttgcgatgg acccaaacaa cagctggaac catcaggtat 3552241 tcccgatcga tactgataca atccgcgccc agcttgcaac aattacggac ggcatcggcg 3552301 tggacgccat gaaaacagga atgctgccaa ccgttgacat tatcgagctt gcggcaaaaa 3552361 cgatcaaaga aaaacaatta aaaaatgtgg taattgaccc ggttatggtt tgcaaaggtg 3552421 ctaatgaagt cctttatccg gagcacgccc aagccctgcg tgagcaattg gctccgctag 3552481 ccactgtcat tacgccaaac ttgtttgaag ccagccagct cagcggcatg gatgaactaa 3552541 aaacagttga cgatatgatc gaagccgcga aaaaaattca cgcactcggc gctcaatatg 3552601 tcgtcattac aggcggaggc aaactcaaac acgagaaagc cgttgatgtt ctctatgacg 3552661 gagaaacagc ggaagtcctt gaaagcgaaa tgatcgatac gccttataca catggcgcag 3552721 gctgtacatt ctcagcagcc gtgacagcgg agcttgccaa aggtgcggaa gtcaaagaag 3552781 ccatttacgc agcgaaagaa ttcatcacag cggccattaa agaatccttc ccgctaaacc 3552841 agtatgttgg tcctacgaag cattctgcac tgcgcctgaa tcaacaatca taaaaaaagg 3552901 ggctgcctta cagagaggca gcccttttta aatcaccgaa gacttttcac agaaaaaact 3552961 gccgatccca tcggcagcct gtttatttga tttttaaatt gtttgcagat ttcctcaaaa 3553021 atgtttctat cgactgaaca aaaagtgcat attccttcat ttgttcatat gcccgcgtga 3553081 gaatttccgc cgtttcactg tgcggcgttg ttccgccaag catttttttc agctgaagca 3553141 gcacatcctt atattcttct cgcttatctt caacttggtt agcagccttt tccaaacatt 3553201 ccggtgttat cttctgttca tgtatattca agaaaacaac tccttttaca gaaaaaaata 3553261 gtaggttatc gttgaagaat agcacagatg gctcagattt cacataagaa aatagaagga 3553321 ttttctacat aagtgtccaa attccgacat tcatttcaga tttcccggtc gcactggctg 3553381 ttacttcatg atttcccggg aaaggaaaat atcttgcact caagacctct tctccgttat 3553441 tgataaagat ttccacagat gacgcgtcga gaaacatgtg tacggtatgc aaatccttga 3553501 tgcggcaatg tctcgcttct gttctttttc cgtcaaagct ctttcgttcc agcgtaacaa 3553561 tcccctcgtc tttatggaag gaaaacgtag ccgttccgcg gatactgatt gaaaagccag 3553621 actccgtatg aatgtcttcc agtagaatct cagttctttc aggtttttcc actggaagcg 3553681 caccagatga tccatgcatg ttgatgtgta tttttttctc atttctgcgc atggctttta 3553741 gctcaggcag cggctgctga atcagcttct gtcctgaaag cgtcagctgt ctcggcagcg 3553801 tcatgcagtg aatccagtgg cagtcaatgg tcggatggga cccttcatcc tgatcaggca 3553861 ccgccatcca tgcaaataaa atccgccttc cctgatcgtc ttcaagtgtt tgcggcgcgt 3553921 aaaaatcaaa accttgatca agctccgtaa attcaccatg cttcagttca ggcttgttat 3553981 aatcgaggcg gccgacaaaa taacctgatt gatatacgtt ctgataacgg aaaccgtcag 3554041 cctcaagccc ttgaggcgaa acaatcagca catccgatcc ttgaagggaa aacaaatcag 3554101 ggcattccca catgtatcca aaatcgtcca gcccgttgaa gcccgcgccg gttatcgggc 3554161 caagaaatct ccactctgtc aggttatcag aagcaaacaa cacagcctgc cctttcaaat 3554221 tctctgtttg cgcaccaatc accatatacc atgtgccttc atgctcccat accttcggat 3554281 cgcgaaaatg cgccgtatat ccttccggaa ggcgggcgac gacacccttt ttctcaaagg 3554341 acagcccgtc gtcagaaaca gcaaggcatt gatacgtttc ccgatttcca tcctgatccc 3554401 tgacatttcc tgtgtaaaaa agatagagcc gatcgtcttt cgtgacagcg ctgcccgagt 3554461 agcagccgtt tttatcaaac caatcactcg gagccagcgc aatctcttcc cgcttccaat 3554521 tcacaacatc ctgtgtcgta taatgccccc aaaattttgc gccgtgcccc gtctgaaacg 3554581 gctgccactg aaagaataca tgatagctgc ccttccaata aatcacgcca ttcgggtcat 3554641 tcagcagccc aaccggcggc atgatatgaa aatgctggcg gtgcggatcg ctgttagcga 3554701 tgggctcttt tttctccact tcttcataag cccggcgacg aagctcctgg tcatgtgctg 3554761 tcattttttc ctctcctcat cctcattaat cttcatgaca aatgctgcaa tgaacgctga 3554821 cactgccgca atcgccatgc caatcagata gtgaatcaag ttgctgaagc caaacggagc 3554881 cgcaatggcg atcatcggaa ttcccgttaa cccgtaagcg tttgcagcta catgtgtaaa 3554941 gacgacatat gccccaccca atgcgcctcc gatcatcgcg gcgataaacg gttttcggta 3555001 gcgcagattg actccgaata tgacgggctc agtaatgccg agaaaagcgg aaaatgctgc 3555061 cggaagcgcg atttcttttg tctttgcctt tttcgccata aagaagacgg caagacctgc 3555121 cccgccctgt gcgacattcg ccattgacca gatcggcagc aagtagtttt tgcctatatc 3555181 tgcaattagc cctgcctcaa tcgcatggaa gctgtgatga acgcctgtca gcacgatgag 3555241 tgaatacgtg cccccgaaaa tcagacctgc gacaaaaccg gcatggtcat atacataagt 3555301 taaagcaacc gtaatgccgg agccaagcgc tctgcctaga gggccaatcg cgataaaagc 3555361 aacaaacccg gtgacaatca cagtaacaaa tggtgtaaca agcaaatcca ccgcatgtgg 3555421 aaccactttt ctcgtccatt tctctacctt gctcatcaca tacaccgcaa gcaggacagg 3555481 gataacagtt ccctggtagc cgagaagagc gatatcaaat ccgaaaagat gcatgtaatc 3555541 aggtgtcgct tccgccaatc cccatggatt taaaagattc ggatgaatca tgattccccc 3555601 gatgaccgct cccaagtatg gattgctgcc aaactctttt gaagcgctga ccccgattag 3555661 aatcggcaag aaaatgaatg ctgcacttga aaacatatca agcagctgca aaagcgcaga 3555721 atccttgctc atccaatgaa acgcattgat catacccagc aatcccatta ataggccgct 3555781 ggctacaata gctgggatga ttggaacaaa aatattagaa agcgttttcg caaatctcgc 3555841 agcgggattc agcttttctt ttgccgcatc ctgatgattg acgtgttctt cacgctcgat 3555901 atcagcttct ttagaaaagg catcgaatac tttattcaca aggcctgttc cgaaaatgat 3555961 ctggtactgg ccagagctgc tgaaagcccc tttaacgcca tcaagctctt ctacttgtgc 3556021 ttgatctatc tttgattcat ctttcatcac taaacgcagt cttgttgcac aatgagccgc 3556081 gctgataata ttttctttcc ctccgagaag ctcaatgagg cgttttgcag tctctttgta 3556141 atccatctat ttctccccct tttatttaaa caaaaaagac ctaaaattcg ccaacgaata 3556201 aaggacacag cgatcctttt tcatttacgc aaattttagg tcttgcctgc tttaccagtc 3556261 acaatcccgc ttattcagat taagaatacg ctttcatcat aaatcatgat agcgttttcg 3556321 tcaactattt ttttagttaa atagtttgat ataacatgta gacaaaaatt cgtaaaaatt 3556381 aattgtgaaa tacttcacaa tatcgtgcta tactatgctc aatcatgaaa gaaagcagga 3556441 aaagacaatg gaaactcaag cattacaaaa ggttgaacag tatgctttga aaaaacaaaa 3556501 catattcgct tcaagcaaaa tccgttatgt gcttcggtcc attttggcca gtatatttat 3556561 tggttttggc attacagccg caagcaaaac aggcagctat ttctttatgg ctgattctcc 3556621 gtttgccttt ccggcagccg ctgtcacttt cggggccgct attctgatga ttgcttacgg 3556681 aggcggagat ttatttaccg gcaacacctt ttatttcacc tataccgcgc tccggaaaaa 3556741 aatcagctgg cgcgacaccc tatacttgtg gatgtcaagc tatgccggca atttaatcgg 3556801 cgccattctg tttgccatcc tgatcagcgc gacgggactt tttgaggagc cttctgttca 3556861 ttcctttttg attcatttgg cagagcacaa aatggagccg ccggcttccg aattgttttt 3556921 cagaggaatg ctgtgcaatt ggcttgtgtg cctcgccttt ttcattccaa tgtctctcaa 3556981 aggggaagga gcaaagcttt ttaccatgat gcttttcgtt ttctgcttct ttatttccgg 3557041 ctttgaacac agcattgcca atatgtgcac attcgccatc tcgcttttga tcgagcaccc 3557101 tgatacagtg acactgatgg gagcagtcag aaacttaatc cccgttacgc tcggcaatct 3557161 gaccgcggga atagttatga tgggctggat gtactacaca ctgaatcctg atcaataaaa 3557221 aaacttccag agatcactcc ctgcaagtca aagcggttat tccgagagat cttgaagacg 3557281 ctggacatgc agcgtgatat agccggcctc ggattccggc aaatgtaatt gatattcatt 3557341 tttcaaaaac tccgccagct ccagcgcaca ttgataggcg aatgaatact ttttttggat 3557401 gaaataaagc atctcctcgt ccatacgatg gagcgcttca tttgattcca accggctgac 3557461 cgcgtatcgc aaatgcgtga caaggcgttg ataggaaatg ctgttttcat ccacctttcg 3557521 attaaagtat tgttttattt tctctatcat ttctttgatc atggtcgtat gcttcagcgc 3557581 tgaatacatg ctctccgcat ccatcttcgc cgtatggatg tgaagggcaa tataacccgc 3557641 ttcatcttca ggcagagaca cgcccaatgt ctcttttaca tgtccgatcg cccacaggcc 3557701 gatctcatat tcttttttat agagcgcctt tatctcatgc agcaatttat tctgcacaag 3557761 cagcccattt tgaatccttt cgatcgcaaa ggacaaatgg tcggaaagcg cgatatgaat 3557821 gtgatcgctc agcggcgccg cgagctctcc ttccgcatag ctgatgatat cctcagctat 3557881 ttctatatgc tcctccggca gtgtttgcag gatttgtttg aacttttcat tctcgtcgcg 3557941 cacgacaaag atcttttcca ctttattcat agggatgaga tcatttttct ttttttgaaa 3558001 agcgattccc ggtcccatca cgattttttc ctgatcatcc tcttttatta aagccgcatt 3558061 gttgtttaat actttataga ttttcaagag gttatctctc ccgccaattt gcttttgact 3558121 gggattttac ctccttttga ccgccatgta aagatgcggg cccgctctct cctgctttgg 3558181 cgattccttg aaggcttgca aacatcttct tttataaagc gcggcggctt tcgctttctg 3558241 cttttcttcc tcattcacag ccatccgcca ttcataaaac gaaacgagtc ctgcggcctg 3558301 cacagccgcc tttctttggt atgtacgctg agccgaatag accgcggcag ccgcagtttt 3558361 tctgtccggc gtcacccagt tcatcaaaaa gaccatccac acccgtaaag atacaagcaa 3558421 acgtttcata gaaaaacatc cctccgcttc tttttggcag gcagcctttt tagcagcccg 3558481 ttttctcagc cgcagcccgc aagaaaagac ggccgatttc ttttctcgca aactagcggc 3558541 tctagcaaaa ctcatgactc tatgatagac cgtggaaaga gaattctttg tcacaatatg 3558601 agtgaaaaaa ccaactagtt tttagaagtt ttgttgaaag ctgaaagaat tgaaatgaaa 3558661 attggagaac cgctttgaaa actttataca caagttatcc caaagataag aacaacttaa 3558721 tcacaagaga tatccacatg tccacaaact ctatctatat tttgtatacg aacgtatatt 3558781 cctaactata tatatacaca ggtttattca cttatacaca gggttctgtg tataactcct 3558841 tcgttataca caaacaaaat ccaataaatg gtccaaatga cacaaggatt tttttgaatt 3558901 ttcaagaaat atatactaga tctttcacat tttttctaaa tacaaagggg gaaacacatt 3558961 gaaaaagggg atcattcgct ttctgcttgt aagtttcgtc ttattttttg cgttatccac 3559021 aggcattacg ggcgttcagg cagctccggc ttcttcaaaa acgtcggctg atctggaaaa 3559081 agccgaggta ttcggtgata tcgatatgac gacaagcaaa aaaacaaccg ttatagtgga 3559141 attaaaagaa aaatccttgg cagaagcgaa ggaagcggga gaaagccaat cgaaaagcaa 3559201 gctgaaaacc gctcgcacca aagcaaaaaa caaagcaatc aaagcagtga aaaacggaaa 3559261 agtaaaccgg gaatatgagc aggtattctc aggcttctct atgaagcttc cagctaatga 3559321 gattccaaaa cttctagcgg taaaagacgt taaggcagtg tacccgaacg tcacatataa 3559381 aacagacaat atgaaggata aagacgtcac aatctccgaa gacgccgtat ctccgcaaat 3559441 ggatgacagt gcgccttata tcggagcaaa cgatgcatgg gatttaggct acacaggaaa 3559501 aggcatcaag gtggcgatta ttgacactgg ggttgaatac aatcacccag atctgaagaa 3559561 aaactttgga caatataaag gatacgattt tgtggacaat gattacgatc caaaagaaac 3559621 accaaccggc gatccgaggg gcgaggcaac tgaccatggc acacacgtag ccggaactgt 3559681 ggctgcaaac ggaacgatta aaggcgtagc gcctgatgcc acacttcttg cttatcgtgt 3559741 gttagggcct ggcggaagcg gcacaacgga aaacgtcatc gcgggcgtgg aacgtgcagt 3559801 gcaggacggg gcagatgtga tgaacctgtc tctcggaaac tctttaaaca acccggactg 3559861 ggcgacaagc acagcgcttg actgggccat gtcagaaggc gttgtcgctg ttacctcaaa 3559921 cggcaacagc ggaccgaacg gctggacagt cggatcgccg ggcacatcaa gagaagcgat 3559981 ttctgtcggt gcgactcagc tgccgctcaa tgaatacgcc gtcactttcg gctcctactc 3560041 ttcagcaaaa gtgatgggct acaacaaaga ggacgacgtc aaagcgctca ataacaaaga 3560101 agttgagctt gtcgaagcgg gaatcggcga agcaaaggat tttgaaggga aagacctgac 3560161 aggcaaagtc gccgttgtca aacgaggcag cattgcattt gtggataaag cggataacgc 3560221 taaaaaagcc ggtgcaatcg gcatggttgt gtataacaac ctctctggag aaattgaagc 3560281 caatgtgcca ggcatgtctg tcccaacgat taagctttca ttagaagacg gcgaaaaact 3560341 cgtcagcgcc ctgaaagctg gtgagacaaa aacaacattc aagttgacgg tctcaaaagc 3560401 gctcggtgaa caagtcgctg atttctcatc acgcggccct gttatggata cgtggatgat 3560461 taagcctgat atttccgcgc caggggtcaa tatcgtgagc acgatcccaa cacacgatcc 3560521 tgaccatcca tacggctacg gatcaaaaca aggaacaagc atggcatcgc ctcatattgc 3560581 cggagcggtt gccgttatta aacaagccaa accaaagtgg agcgttgaac agattaaagc 3560641 cgccatcatg aataccgctg tcactttaaa ggatagcgat ggggaagtat atccgcataa 3560701 cgctcaaggc gcaggcagcg caagaattat gaacgcaatc aaagccgatt cgctcgtctc 3560761 acctggaagc tattcatacg gcacgttctt gaaggaaaac ggaaacgaaa caaaaaatga 3560821 aacgtttacg attgaaaatc aatcttccat tagaaagtca tacacacttg aatactcatt 3560881 taatggcagc ggcatttcca catccggcac aagccgtgtt gtgattccgg cacatcaaac 3560941 cgggaaagcc actgcaaaag taaaggtcaa tacgaagaaa acaaaagctg gcacctatga 3561001 aggaacggtt atcgtcagag aaggcggaaa aacggtcgct aaggtaccta cattgctgat 3561061 tgtgaaagag cccgattatc cgagagtcac atctgtctct gtcagcgaag ggtctgtaca 3561121 aggtacctat caaattgaaa cctaccttcc tgcgggagcg gaagagctgg cgttcctcgt 3561181 ctatgacagc aaccttgatt tcgcaggcca agccggcatt tataaaaacc aagataaagg 3561241 ttaccagtac tttgactggg acggcacgat taatggcgga accaaacttc cggccggaga 3561301 gtattacttg ctcgcatatg ccgcgaacaa aggcaagtca agccaggttt tgaccgaaga 3561361 acctttcact gttgaataag aaaaagccct gccgattcgg cagggctttt taaagatcag 3561421 tcagcaaacg cctcctgcaa taagcgatac gatcggagct tatcttcaaa atgatgcgtg 3561481 atggtcacca ccatgatttc ctctgtttca tacgcgttac tcaaagctaa cagccgctcc 3561541 ttaacctgtt ctttcgtacc aacaatcatt cgatttcgat tatcagcaat tcgtctctgt 3561601 tcataaggag aatacgtatt tttccgaaca gcttcatacg aaggaactcc ctctaaagga 3561661 ataccctgct ctcccgccaa aagtgtaaaa tcaagcacag ccccaagctc ctctgccttc 3561721 tcctccgtgt cagcacaaag aacaaaaaca gcaactgccg ctcgaggcgt atctcctaac 3561781 acagacggtt tgaatcgcct cttatactgt ctgacagtac cctctccgcc ctctccattg 3561841 ataaaatggg caaacatata gccagcgcca gattcagctg cgagcagcgc gctttctcca 3561901 gatgagccga gcagccacac atccggagcc gttgaaatat gcggcgcagc ggtcagattc 3561961 ggaaaacggt gtttgtcatc cgccaaatca tgcaaataca tggtcagctc cttaatttgc 3562021 tgcggatact gatcagcatt gcgcttacca ccgtcattca gcgcccatga tgcaatcggc 3562081 attccccccg gtgctctgcc aagccccagg tcaattcttc ctggtgtcag cccctccaga 3562141 acacgaaagt tttcagctac tttataagca ctgtaatgcg gcagcatgac tcctcctgat 3562201 ccaacacgaa ttcgctttgt tttcgctgct atatgactga ttagcacctc aggactggac 3562261 cctgccagcc gttttgaaaa gtgatgctca gaaacccaaa atctcttata tccaaggtcc 3562321 tcagcagctt gggcaagcgc aacggtttgc tgtaaggccg tttctgcatt gctgccctct 3562381 gatactggag attgatctaa tatacttaat gaaaccatcc ctaccacctc atcctcatcg 3562441 tatcactgat cccctatttt ttctccaaag ccgctcacac tgcttatcag tgtcccctat 3562501 cattcgccat ttatttgtga aagcatgtcc ctatttgtcg gaatatgtta cacgtgaaac 3562561 ataaaaaccc ctccagacgg agaggtttgc tttagttttt attaaagccc ttttctttca 3562621 cgtagtcatt taaatacgta cgcggctttt gcttcataaa gttcagtatt tgatcggacc 3562681 acgtttcttc ccgcttcccg tttgttcttt ctctatagta atcagaaatg gttttgtcat 3562741 acgtattcat agtatgacgg aaatcgtctg tgttcacatt atacgtattt tcatgataaa 3562801 cggcctgctt tggcaatctc ggttttttgc cggaaaggtt cgcaggatgg cctactgcca 3562861 gtccgaaaag cgggagcaca tggtcaggcg tttgcagcac ctctgtcacc ttgtccaatt 3562921 cattccgaat gccgccgata tagcaaatgc caagccccat ggattcagcg gcaatgctca 3562981 tattttgcgc tgccagcgcc gcatcaatca agctaaccat aaacatttct gtattctcga 3563041 gcagctcaga aatatgttca cctttttcct cagccagttg ttgatggcgg tacaaatccg 3563101 cacaaaatac aaaaaagtgt ccgttcttct caacgtaagg ctgattccca gcaagcacgg 3563161 acagctcacg ttttttctca ggatcagaaa ccccgataat cgaatatgcc tgcacatagc 3563221 tggatgtaga cgcagcctgc gcacttttca ctaatgtatc aatttcttca gctgtcaaaa 3563281 gctgatcagt aaaagaccgg attgaccgat gattcaaaat ggtttcgatt gtgttattca 3563341 tcacaaaaac ctccttatca ctttttatca tatccgaaaa aaagtgatct caaaagtgaa 3563401 atgctctgca caaaaaaaga cagcctctgt aaaggctgtc tgcatatcaa gaattaaaaa 3563461 gataacttct gtatttcgtc agctgcacac ttgcattata tacaatccca aatccgatta 3563521 acgtggaaag tgtcgagctt cccccatagc tgacaaacag cagcggaatc ccggtaacag 3563581 gcataatgcc aatgttcatt ccgatattct ggaatgtgtg gatcacaatt aacgccgtat 3563641 agccaacgca aaagaaagaa gcgaaacggt taaacggatg tattttgtct atcagaacaa 3563701 caagcctgta gattaaaaag aagaacatga tgacaacaat tgcacagcct ataaagccaa 3563761 atgactcacc tattatagaa aagataaagt cagtcgtact ctctggaaca taaaccttca 3563821 aattagaaat accattacct aaaataccac cagatcctat tgccatgatg gcctggtcaa 3563881 cttgccagct gtcatttgaa tcttcctgtg tctcatttga agcagacacc caagaagtga 3563941 cccgcttaat ttgataatcc tgtattccaa ctgatttagc aacgtcagga aagtttatca 3564001 ttactaataa aattaatgaa atgagtaaga tacctgaacc agctatgatc gcaatcaatt 3564061 tccaatttat ccctgacata aaaaccatta caagaacgat aaacatacat attcccgcag 3564121 tcccagcatc ctgcatcagg ataagaccta caggaataac tgcgacaccc gcaatcttta 3564181 ataacaagtg gatatcatcc ctaagcgtcc gaactccttt aggatttgct tttccaataa 3564241 ctgaagcaag catcataatc aaaccaacct tcataaactc tgacggctgt attgttattc 3564301 taccgatcct aaaccaactt tttgcccctt taataacagg tgcaatagac tcgggactga 3564361 ttttaagaat aatcaaagat aaaataccaa tgataaaaat atataaactt aacttttcaa 3564421 gctgttctaa atcaaagtac aaaagaactg taatggctac agcccccaaa agataaaaca 3564481 caatttgctg aatccaatcc gtgttcccat actgcccaaa ctgaccggca gcatatattg 3564541 atactacgct tataataaaa aacacaccaa atataaaaat caaatccccc tggtaaaagg 3564601 ggctttgctg tttcttatat cgactcattc tatcccgcct tacattttca tcggaaaatc 3564661 actaatgttt attatacatg aaccacgttc aagatgacac gtgaagctcg cttcctttta 3564721 tgttttttca gcatttgcgg cgctttttca gctacacgaa atatgacgta tcataaaccg 3564781 aaatgtttcg attgacacaa aacttttcaa atgaaaaaaa cgccatacca atagaatttg 3564841 ttaaaaaacg aatgcgataa tgtgttatgt tcccaaataa tgtgatacct catatagaaa 3564901 tagctaaaaa ttcagagccc catgcccata cattctccta gcacattaaa cgaaaaaata 3564961 agacgataga tccagtccat ttctgcaaaa acacgtatca atttctggaa aacatggtat 3565021 aataattgta acagaatgtt caaaaaacaa tcacaaaaca gacacaactc agttcctcta 3565081 tttcattttt gtaaacgtta tcacaaaatg aaaggagacg ggtatgatgg acatgttttt 3565141 tgcttactta ttggttgcca gcgcaacgcc tctctttatt tggcttgata acaaaaaagt 3565201 cgcactctca gctattccgc caatcatttt aatgtgggta ttcttcttct tttacgcaac 3565261 agaaagcctt tctccacttg gacacactct catgattatc ttgtttgccg ttaacgtcat 3565321 tgtcgctcat atcgccgcat ttatcattta cggccttccg tatcttcgca gaaagcgaag 3565381 cagctgaaga cagcaaaaaa ccctcttcca ctgaagaggg ttttttgtat tattcgttat 3565441 ggcctgaatg ctctgagtgt tcagcgcctc caggaggatt tccgtccata tggtcaccat 3565501 ggtgatagtg agccgcgaaa atccagatgg atccaagtac gataacgatc gcgccaaaga 3565561 atccgaacag cgtgtttccg acttggatcg tgccgttttc gctctctgtc atatgcatga 3565621 acatgagaag ctgcagcgcc gcctgaatga aggcgaagcc gaagataatc caaagttttg 3565681 ctgatgagct caggtcagta tacactgcaa cccatagagc cagcagggtc aaaacgatag 3565741 acaggataaa acctacaatg tgtttccatg gaaagtgact gtgttcagca gatttgtttg 3565801 ccattttaca gaccccccaa tcccatgaga tagacacctg taaagatgaa aatccataca 3565861 acatctaaga agtgccagta caagcttgag ataaagattt tagatgaagt ttgcggagtt 3565921 aagccgcgtt tcttcaactg aatcagaatt cctgtgatcc agaaaatccc gattgttacg 3565981 tgagttccgt gagttccaag taaaacaaag aatccagacc agaacgcact tgtactgaga 3566041 gccgctcctt catgtacata gtgaacaaac tcgttgatct cgcatccgac gaagccggca 3566101 ccgagaagaa gagtgataat tgtccaaatg actacgcctt ttaaacttcc gcggcgcatt 3566161 tcatgaacag cgatcccgca ggtaaagctg ctgatcagca gcaagaacgt cataatcatt 3566221 accagattga cttcaaatag ttcgtctggc aagacacctc cagctgttct gtttttaaga 3566281 acgaagaagg ttgcaaatag tgttgagaac aacacaattt ctgcccctaa aaagatccaa 3566341 aacccgagaa tattaagtct gccggtttca gattgatatt ccataggcgc gttagaattg 3566401 ccgtgttctg catgttccat aactcacgcc tccttattcg gaaatctttc tttccgtctc 3566461 ttttatttca tcaacactaa tgtagtagcc gttgtcgtat tcgaatgaac gcagaaccat 3566521 gcagagcagg actccgatca atccgactac gcccatccag taccattcaa agacaagtcc 3566581 aaagcctgcg agaccgaagg caacagacat aaagaacggt ctgcctgagt tgcttggcat 3566641 atggattttc ttgaatttgc tttcagggta taattcagtt ttttcttctt tcatatgcag 3566701 gaatgcatct tgagatttga cttcaggaag caccgcaaag ttgtaatgcg gcggaatcgc 3566761 agaagaagtc gcccaatcaa gcgtacgtcc cacaccccat gaatctccgc tgatttcacg 3566821 agtagagtaa cggaagctgt agtagatgtt atagcaaagg attaagaatc ctacacccat 3566881 catgaaagct ccgactgttg agataaagtt caatgttgtc cagccgtcat tcggtccgta 3566941 tgtgtaaata cggcgcggca tgccttgaag ccccaagaaa tattgcggga agaaacaaat 3567001 attgaacccg atcataaaga tccagaagaa ccattttccg attctttcgt tcagcttgtg 3567061 gccgaacatt tttggatacc agaaaataaa tccggcgaaa caagcaaata cagtacccgc 3567121 aatcagcaca tagtggaagt gagatacaag gaagtacgta ttatggtatt gataatccgc 3567181 tgctgccatc gcaagcataa cccctgtaac cccgccgata acgaagttag gaatgaacgc 3567241 aagcgcccac agcataggtg ttgtaaagct gattcggcct ttatacattg taaagagcca 3567301 gttaaagatt ttaaccccgg ttgggattga gattgccatt gtcgtaattg agaagaatga 3567361 gttaacggac gcactgttcc ccattgtgaa gaagtggtga gtccaaacta agaaactcaa 3567421 tacagagatg gcgataatag aaccaaccat cgctttgtaa ccaaacaatt gttttcttgc 3567481 aaagcttgag atgatttctg agaaaatacc aaacgccgga agaataacga tatatacttc 3567541 aggatgtccc caaatccaga acaagttagc ccaaagcatc ggcataccgc ctgcttccaa 3567601 tgtgaaaaag tgagcgccga acaaacgatc aaatgataaa agtgctaatg ctactgtaag 3567661 tacagggaac gcaaacacga taataaccat tgtgatcagt gttgtccatg tgaacatcgg 3567721 catacgcatt aatgtcatgc cttttgttct catttttaag attgttacca taaagttgat 3567781 ccctgtcatc agggtaccga taccggcaat ctgaagtccg aggaggtagt agttctcacc 3567841 cggcccaggg ctcatgtcgt tacttgcaag cggcatataa ctcgtccagc ctgcgttcgg 3567901 agaacctccg ataacgaaag aaatattgaa aagcatcgcc cctacaaaga acgtccagaa 3567961 gctcaggttg ttcaagtaag ggaacgcaac gtcgcgggca ccgatttgaa gaggcacaac 3568021 aacgttgata agaccgatta agaacggcat cgccatgaag atgatcatga ttgtaccgtg 3568081 agttgtaaaa atttcattat agtggtttga gtctaaaaaa ctgttattcg gaagcgctag 3568141 ctgggcacgc atcatcagac cgtcgacacc gccacggaat aacataatta cagcagatat 3568201 aatatacatg attccgagtt ttttatggtc aacagtagtt atccattcag accacagcca 3568261 tttccacttt ttgaagtaag tcagaacaaa aataatggca atggttgaaa gcgcaatgga 3568321 aacttgtgcg cccagaatta atgggtcacc agttacgaaa aattcgtccc atttgaattt 3568381 catgcaggct tcctcctttc ctgatcaata tcattcttct gtatcatcag acttcttaaa 3568441 ttcgtttttc tttacgtttt caaacggatc tgttttagaa tgcggtgaaa cggcttgata 3568501 gccaaggcgt ttgcgcgcct ccatcgcgta ctcagcgtct tgtccgtgat caacgtattt 3568561 caagtgagta gaagagaacg ttaattcgtc cacattttca ggaagcatca attcatcata 3568621 cttctctttt gtcagcttag gagcctcgtt ctgagtcttt ttcacccagc tgttaaagtc 3568681 tttttctgtg actgcattca catcaaactc ttggtctgca aaatgttcac ctgtgaagtt 3568741 cgcgttgcgg ccttcgtaag tacccacttt gtcagcctgt aagtattgat ccatcagcat 3568801 tcctgccatc gcatattttt gccctccaag ctgaggaatc catagcgaag ccattgaatc 3568861 tgcagatgag attttgaaca agatcgggcg gtcgacagga atgtttaagt agttgaccgt 3568921 ttcaatatcc tgttcagggt agctaaatac ccatttccag tctaccgaag tagcataaac 3568981 aacaagaggc tctttgtctt ttgttgcttc aggagctttt tctaacgaat atatcgtctg 3569041 tactgttggc acagaaagtg caatgacgat taaaattggg atcactgtcc agactacttc 3569101 taaaaacgtg ttaccgtgaa tttctgggtt ataagatcca ttatctttgc ctttacggtc 3569161 gcggtatttt actaaaataa tggtaaatag aacaaagacg accccgacga taaacagcat 3569221 aaatccgata gataacagga ttaaatcact ttgctgttca gctacaggtc ctttcggatc 3569281 tagtactgaa gcattgctgc atcccccaag gacgaaaacc acagttaaca gcgctaatac 3569341 aagcaacggt tttaatgctc tgaacaagaa gatcaccatc cttcctattg atgtaataaa 3569401 tctgaagtgc atacttcctc aaaatctttt ctctactttg ttatgctatc aaaaacttca 3569461 cttattagct ttattttttt ataaacttca tcccattttc gcttaaatgt cataaaatcg 3569521 acaaaaattg ctccaacttt attcacatct atcgcttaag atgaaaagtt tctagttatt 3569581 tccgcatata aagtaaagaa agatgatgaa gaactaattc tgacaaatta aggtttacca 3569641 caataaaaaa cttaggtcaa tcaaaaattt cattttgtta aactttctag ataggaatta 3569701 ttttttcctc gtctagcatc ttttcacacg gttaccattt taacgcatca aatattgaaa 3569761 gaaaaggcgc aatgaagagc caatatgctc tgaattgtcc gtattttttt atgagagcat 3569821 ccagttgttt atcttataca aaaaagagga atgatataag caaataaata aaaaatagga 3569881 tgtgttgcat gatgagtttt cttatttcac ttatcgtcgc tattattatc ggatggcttg 3569941 gaagcctgtt tgtaaaagga gatatgcccg gaggaattat cgggtctatg atcgcaggtc 3570001 ttataggcgc ctggatcgga cacgggctgc ttggaacatg ggggccgcac ctagccggat 3570061 ttgccattat tccagcggta atcggcgcag ccattgttgt ctttctagta agcctgttaa 3570121 ccagaaaaag aggataaaag cagcagcacc cgaagcgtca gcgctttggg tgtttgtttt 3570181 gccataaaaa tcgaaaaagc ctcaacccta gcggttgagg cttttgactg gtttggcgcc 3570241 caactgatcg atgaaccttc tgaaggcctg ttttccctct gctgtctgct taaatacacc 3570301 ggcgtgttca aggatgcgcg cgaatacatg tcccagctct tcttttatga ctagatctac 3570361 gttctctttt gttatggttc ttttttccat cgtccgaaga gcccactcac tatgctttgc 3570421 agtgagcgga ttttgttcta aggctgtttt cggatcagca gaacatagcg ccgctgccgt 3570481 ttctttcatt tcctcctgta agcggccagg caatatcgcc aatcccatga cctcaatcag 3570541 gccgatattt tcttttttaa tatggtggac ttcttgatga ggatgaaata ttcctaatgg 3570601 atgctcctca tccgtccggt tgttcctcag tacgatatcg agttcgtaca agtctcccct 3570661 gcgccgcgca atcggtgtga ccgtattatg gggcgtatcg cctgtatagg cggcaatgcc 3570721 ggctttttca tcggaatacg tctgccacgt gcggaagata tggtcagcag cttcggcgac 3570781 atgacccggt tcgtctcctt ggagcctgag cacagacatc ggccacttca ctaagcccag 3570841 cgacacgccg ggataatcat ttaattcata aacgtcttcc gcttctgcac gtgccattgg 3570901 aaaatcatgc gcgccgcctt ggaaatgatc atggcttagg atgctgccgc cgacaatcgg 3570961 cagatccgcg tttgaaccga taaaataatg cggatattgg ccaagaaatg acagcagcct 3571021 ttcaaatgtt tttttgctga tctccatcgg ttcatgttca ccttttaaga caatgcagtg 3571081 ctccggataa tagacatatg gcgagaattg caggaaccat tgttcgtcct caaggatgac 3571141 cggaatgatt ctgtgatttt gccgggctgg atgattcacg cttccctcga agccgacatt 3571201 ttctttacac agcaaacaca tcggataatt tgtctgttcc tgctcttttg cagccgcaat 3571261 cgctttcggg tccttttcag gctttgatag gttaatggtc atttccagct cgccatattc 3571321 ggtcggcacc gtccaatgaa catttttggc gattctgtca gtccgtatat aatagacatc 3571381 ctctgaatat tgatagaatt cctttgtcgc ctgttttggg ccgtataatg cttttgtctc 3571441 ttcaaatttg cgaatgacct cggacggggc aggcacaaaa cagcccatca gctttgcgct 3571501 gagcaggtca cggtacgtat ctgtatccgc ttccattcgg ccggtttcgg cagcccattt 3571561 atagatggga gctagcaagt ccggcaggct ttgtgactgc ttgatgctgg tgctggagtt 3571621 cggctcggga tgtgtgatgc ccagcgcttc ataaagacgg tttctcgtat attcccgatc 3571681 ccagatcgaa atcaattttc gttccaggcc atactcaagc agctgttcca gatgttcaat 3571741 aatactcata tgtcactccc cctttagttc tctcgctccc tctccgatat ccgcgacata 3571801 aaagtccgct cggagccctg ttttttcttg atatctgtct ccaaccttct gaataaaatc 3571861 atcaacgaac tcatctttta caatgctgat ggtgcagccg ccaaagcctg ctcccgtcat 3571921 tcttgatcca attacacctt cgtgatccca tgccgcaaac acaagctcat caagttcagg 3571981 gcatgttact tcatagtcat ccttcaatga aaggtgggat tccttcatta actgcccgat 3572041 ttcatctata ttgttctctt tgaacatatg ggccgtctta atagcacgat gattttcgta 3572101 tacagcgtgc tttgcccggc gtctgttcgt ttcattttgg atcaggctgg aatgcgcatc 3572161 gaaatcagaa ggcttgatgt cgcccagtgc ggcaatatcg aggccttttt tcagatcaag 3572221 caatgcatca ttgcattctt ggcgtctcgt attatagctg gagtcagcca atgtcctttt 3572281 tttgttcgtg ttcgcgatga ccagcgcgag gcctgagaca ttgagtttgc tatattcata 3572341 gtcaagcgtg tcacagttca gcagcatcgc atgatgtttt ttccccattc caattgcaaa 3572401 ttggtccata attccgcaat tgacgccgat aaaatggttt tccgcatgct gcgccatttt 3572461 cacaagctca agcgcatcta cttcaggatg aaaataactt tggagcacga cccccatcag 3572521 cagttcaata gaagcggaag acgacagtcc cgccccgttt ggaatattcc ctgaaaatac 3572581 aatgtcaaag ccatggggaa ctgcatatcc cctctgttga aattcataaa tcacgccttt 3572641 tgggtagttc gcccagtcgt cttctttttg atagcgaatg tcgtcaaggc tgcattcctt 3572701 gatgcctgcg tttctaaagt tatctgaata catccggaca agcccgtcgt ttctttctgc 3572761 aacagcagca tatgtaccca ttgtcagcgc gcacggaaag acatgcccgc cgttatagtc 3572821 tgtatgttct ccaatcagat tcactcttcc aggtgcgaaa aaaaaccgta acccctcttt 3572881 ttctccgaat acacttgcaa atatcccctt tagctcttcc cgcatgtgca atcacctttc 3572941 tggtttttat tttttattcc ccttatttct tcatagaaaa cggcagatca tatgctgcag 3573001 tcctctcata ccccttcttc ttttgttttt ttaaagacga gccatttgct cgcaacatag 3573061 ttgacgacaa caatgaccgc gttgtcgagt attttggcca aggtttcatt tgtattgaac 3573121 tggccgacaa gaatgatcat catgcctaaa tctatgccga gagacaggac ccgaacgctg 3573181 aaaaaagcag tgagctcttt cagcaggctc tgcagatcat gtgttttttg ctgaaacaca 3573241 tataatttat ttgttatgta agcaaacagc acggacaaaa tccaagcggc aacagtggcg 3573301 gctttgtaat ccacattcat gatctctacc aatatataaa agctggcgat attcacaatg 3573361 gttgtgaaaa cccccataat gatatacata attatttctc tatacttcac tgatgttcct 3573421 cgctttctga aaaacttttc aaaattcttg gcctctcgtg ctctctgtct aaagtaaaaa 3573481 ataccgagag tgcgtctaaa aagctgcgga aggtggctgg ctggcccaat acatatgatt 3573541 gtttgatgat tccgtcgagg actgcacata ttattttagc cgtatattca ggatcaatac 3573601 aggcgtcaat cagctttctc tccttcagcc acttaatata taacacattt tcttccaccc 3573661 acaattcgta cagccggaca taggccttgc atttctttaa gactttatat gtcggcatgt 3573721 tcatggcaaa cgaggtgatg tcccacgacg gcttatttat gtaataggaa taaagcagtt 3573781 ctgcagcgtg ttttgcagcc tcgtccaatg tcagcgattt cactgactcc cgctccattt 3573841 gatcaagata ccctataatg atcttttttt tcatctgacg tttttcgaga aggtacagca 3573901 gaaaatcgtc cttgctgaca aaatgaacat aaaatgctcc tttgctgtac ccggcggctc 3573961 tgctgatatc ttctacagaa accggatcat acgctcggtc aatcaacaaa ttcacgccag 3574021 cgtctataaa actttcaaat gttgcttctc ttttaatttg aaatttgttt tttttcatat 3574081 ttttctcctg gcggtaatga ttacccttat cttacaccgg atcaatcttt agcggtattt 3574141 atttctttaa acggttatgc tattcggttt cccaggggtc atttttaata ggctaaatga 3574201 tttattttca tttacatact atccagtcag tatttaattg tttattatta taaataaggt 3574261 ccattggtta tattagtcat ttttttaggg aataggtagg tggtttttcc ttcagtttgt 3574321 gaacaccgag caactatgtg tgaaatttgt tgtactcgcc tccatcatcg cgctggcttg 3574381 tcttttattg cccgcatgtt gcaggaaaac attttataca attggaggtt actatgaaaa 3574441 ctcatgttaa aaaagatttg gacaaaggtt ggcatatgtt aattcaagaa gctagatcca 3574501 ttggattagg cattcatgat gtgaggcagt ttttagaatc tgagacagca tcaagaaaga 3574561 aaaaccacaa aaaaaccgtc cggcaagact agtccgaaca ggcggatcta tttacctctg 3574621 gcttttctat cacctgatct gagttttcac catatcctct attcaaaagc aaatcgctgc 3574681 gctgagcttg aggacaaacg gtgtgtcagc taactacgac agacagccgg tgatgcgatc 3574741 acctcttggc acatgcattg tcataaagag gtgatgcgaa catgataacc gtgctctggt 3574801 aaacagcagc tttgctgaga acaagctgca ttcggtgagg ttttgaaagc aaactcgttt 3574861 atacacggcc gagcttgaaa accttcgcct gtctttagac cactgtgttc acctcttcac 3574921 gacttccttc ttttttcatc ctccagctat tgtacaacgc ataaatcgga ctttcagtac 3574981 atacctattg gtgtaccttt ttgcttacgt ttagcgaata aaaggaggaa agccatgtac 3575041 aaagctgatt ataaacagat tgctgcaacg ccgtcttttc aagctttttt aaagcagaaa 3575101 cgcgctttta ttgttccttc tgcgattttc ttttttgttt tttatttttc actccctgtt 3575161 ttgacatctt atttcacctt tttgaatgca ccggccattg gagctgtttc atgggcttgg 3575221 ctgttcgcca tcgcccaatt cgctatgacc tggatactga gtactgtgta ttcccggaga 3575281 gccgcccatt tcgataagta tgtaagcgct ttaaaagagg atctgaaggg tgaacagaca 3575341 tgaatatgac tgctttttta ttatttttgg cgattgttgg cctgacgctt attatcacgt 3575401 attttgccgc gaagcggacg aaaacgacga gtgagtttta tacggcgggc ggcgggctca 3575461 ccggcgttca gaatggactg gcaattgccg gtgactacat gtctgccgcc tcgtttctcg 3575521 ggattgccgg aatgattgcg ttatatggat ttgatggctt cttttacagc atcggttttc 3575581 tggtggctta tctcgttgtc ttgtacatcg tggcggagcc gcttcggaat cttggaaagt 3575641 acacgatggc agacatgatt gccgctcgct ttaaagaaaa gaaaatccgc ggtgtcgcgg 3575701 ctctcaatac cattgccatc tctacttttt atatgatcgc ccagctcgtg ggggcgggcg 3575761 cgctgatcaa actgcttcta gggctggatt ataccgcggc tgtcctcatc gtcggagtgc 3575821 tgatgaccat ttatgtcgtg tttggcggca tgatcgcgac aagctgggtt caaattatta 3575881 aagctgtttt gctgatggcc ggcacactcg tgatttcgat tatcgtgttt tcgaaattcg 3575941 gctttagcct taataccatg tttgaacaga tgaaaacggc tactccgctt ggcgctgatt 3576001 ttttgaaccc cggaaataaa tacaaggtgc cgcttgagac cttgtcgtta aacttggcac 3576061 tcgtgctggg aaccgccggg cttccgcata tattgatccg gttttatacc gttaaggatg 3576121 ccaagacggc ccgtacatcc gttgtgtcag cgacatggat tatcggtgtg ttttacatta 3576181 tgacggtatt tctcggcttt ggtgccgcgg catttgtcgg ttttgacgcg attacggcgg 3576241 ctgatcaagc gggaaatatg gcggctccgc ttttagcaaa agcgctcgga ggagactttc 3576301 tgttcgcgtt tgtatcagcc atcgcctttg ccaccatttt ggctgtcgtg acagggttgg 3576361 tgctgtctgc cgcctcagca tttgcccatg atatttacag ccagatcatc agaaagggag 3576421 aagcaactga aaaagaacaa atgaaagcgg ccagatgggc ttctgtcgcc gtgtcagtgc 3576481 tctcgattct ccttgcgatt tttgcacaat ccttaaatgt ggcgttcctt gttgcactcg 3576541 cgtttgcggt agccgccagc gcaaaccttc cgctgattgt gtttacagtc ttctggaaac 3576601 gattcaatgc ctcaggcgct ttatggggca gcctgacagg cctgatcagc gcgcttgtgc 3576661 tggtatcgat gagccctagt gtgtgggacc cggccggagg tgctattttt accggtgatc 3576721 cgctcattcc gctatctaat ccaggaatta tttccatccc gctcggcttt ctcggcgcgt 3576781 ggctcggaac ggtgctgtcg tctgataaaa caattgatga agatacgttt gcagaaattc 3576841 aggtgaaggc gcatactggc gtccatatgg aacaggaata aaaaaagctc tctttatcga 3576901 gagctttttc cttacttttt cttctgctcg tcagaaatcg ctttttcaaa tacatccttg 3576961 ccggcagcac ccggaattac agtgtcaccg ataataaagg ttggaacggc tgtgatgtca 3577021 gcctcttcat aggcgtgctt caaggcttgg cgctgcacgt cctgatatgt tcttgtttcc 3577081 agtgctgatt tgaatgatgc accgtctaat cccacttcct cggcgagctt cgtcaagatg 3577141 tcaatatcgc cgatattttg gtcctcctgg aaaaatgcct gaaagacacg ggtgttgtat 3577201 tcatgtcctt tattgtattc cttcgcaaaa tggaagcctt caaacgcgag gtctgtatac 3577261 ggatggggcg agacgtttgg aaaattgatc tcgactccta atttctccgc cattggctga 3577321 attgatgtct gccacatgta ctgtttagaa ggatcattga ccggatcaag ctgaggagat 3577381 gggcttgggc gcagttcaaa cggcatccac tcgacttcaa catcctttcc ttttatcgct 3577441 tcttcaaaag cggcttttcc aacaaaacaa aatgggcaga cgtaatctga ataaacttta 3577501 atgtgtactg tcatgataat ctcctttcat actaaattga ttttaaactg taacaattaa 3577561 agttacaact gttttttaat aaagaagccg atttaggctt ctttcagatt gatgacaaaa 3577621 tcctaaaaag ttttaggatt ttgtcatcct ttcagcgtga ttgaaaaccc ttgaagtcta 3577681 ggaaagccga gcattggagc ggagcgaatg ctctaattcg tgagcaccaa cgcacaggct 3577741 tgacaacgaa tgcgagggtt tgtcgacacg ctgaaagaag cctgtaaagg cttcttttat 3577801 gattccagca aacgctgggc aatatattct ccttttttgc agccgcctgg gcatgcgtat 3577861 aaagcagaac cgattgtttg tgtatattcg tttaacgcat cctttgctga aagagccttc 3577921 agcatcggga taaactgatt gtcgggattt ttttgaaaac tgataaacag gagacctgca 3577981 tccatatagc cggttttcgg atcaagtcct tctgtgtaag agaaagctct tcgcaaaatt 3578041 tgtttcccag tagatttcgc tagactgacg tgtgaattag acggaatttg attcagcttc 3578101 acgggatctg tttccttttt ctgcccaaaa ggcgcccccg agctttttct gcggccgaag 3578161 gtatcctctt ggtccttgag ggaagagcgg tcccatacct caaggaacat tttgattttc 3578221 cgaaaagcca tataggtgcc gcccgtcatc cagtcaggct caccagactg aatccacacg 3578281 atcgagttca tcaacgtgtc atccttcgtg ctctggttgc ctgttccatc tttaaacccg 3578341 aagaggttgc gcggtgtttc accatttttt ccaccgctta aaaagccttt gttcacaaaa 3578401 cggacctcac aagtgccgac cgcttgattt agcaggttac gcagcgcgtg aaacgccact 3578461 tgctcgtcgt ctgcacacac ttgaatgcag atgtccccgc ctccctgctt ttcatccagg 3578521 ttgtcattgg gcatcgctgg aagagcggct aggtgcttcg gttttttgct tttcagtccg 3578581 aagcggtcct ttccgtcttt ttcaaaaaag ccaggcccga atccgaatgt gaccgttaag 3578641 ttggaagggg ataaatcagc agactcacct gtatcctgcg gcggcagata ctgatttctc 3578701 tgctccgctg acattttctt gccagacgtc agcatctgtg tgagacttgt ccagtttcta 3578761 aataacgtaa tgatgtcgct tttgtctttt gctgttacat ccagtgcagc aaaatagaca 3578821 tacgtctgat gggcagttgt gattccggcc tgatgctttc cgtaaaacgg aacaatctgc 3578881 tcctcctctt tttcatcctt tttcgatggc ttagccgcag tctgaacaag cggagcgaga 3578941 ccgccgagac cgctggcacc gatcgcaacg gctgcccccg ccatcgctcc ccattttaaa 3579001 atgtcccgtc tgtgaatttg ttctggcttt ttctgttcat cgctcatgat gttacaaaac 3579061 tccttttata gcacattcgc aatcttcgac atggtttcag aaagagtcgt cagcttagtg 3579121 ctcagctctc tgatttgctt ttcacttaat ttatcataag acgtatagga ctgatcattt 3579181 gttttgtatt ttgccattaa aacttcaaat tcgctgaact ccgtatccag tttttccgtc 3579241 aagtcggagt gatcttttac aagcgcgctt ttcactgttt gataaacggc ttcggagcct 3579301 tccacatttg ccataaggtc aactaaatca attcgtgagt agcgctcttc ttctcccgtg 3579361 attttcgaaa ttccggcttc gttcagaagc tccatcgcgc ctgcaacaat ttgttcaggt 3579421 gttaatttca gtgattgaat tgaaccgtca agctctttta catccttgag aagctggtca 3579481 gctgttgcct tttccccgga aatatcttga tccttccaaa tggccttctc aagcttatgg 3579541 aagcctgtcc atttgtctcc ttcttcaaca tcgttttctc gtgcgtcaat tttcggatca 3579601 agatctccga ggctttcagc gatcggttcg attcgctcgt aataaacacg cgctttcgca 3579661 tataacgttt tggacttttc gatatcgccg gatttcacag cacccgtaaa tgcttcagtc 3579721 gctttgacaa gctggtcact ctgctctttg acatagcctt tatactcatc cgctgctttt 3579781 gccagctgat cgctagcctt tttgccgctc ttcttcgctt ctgtcaggtc ttctaaggat 3579841 gctttcaatg actcggattc tgtcttgatt tttcctgcat ccggtttgtc tttttgcgct 3579901 tctgtgtaga ttggctgaag atgcttttcg atttctgtat attcgaatgg atagtcgctg 3579961 cgaatatcgt tttcaaagga aagccagtag ctgtttaact ctttcccctt cttttcaatc 3580021 tctttttggt ctcctttttc cactgagtca ttcagcttag aaatgatggt ttccatttta 3580081 tttacggatg cggtgatttc tttagtgacc ccgctttttt cagatgaagc tttttctttg 3580141 gttgaagatg tgtcattggc tccgcagcct gcgcacagcg caaggatgca tccggctgat 3580201 acagcgattt ttgtgaaatt cattttgtca gttcctttcc gtttgtaaaa tgttttgccg 3580261 cttctgaaac aagcgcaatc agtaaaaaga gtaaaatcaa catttgcgga atcgtgctgt 3580321 acacagacgg ataaattcct agcaccgata cagacggcag ccagctttct gcatcagacg 3580381 gaagaatgcc cgccagttga aggctgtgaa cgccggttcc gagaaatttc acgcacatat 3580441 acaggacaac cgccattgat agaagaaaaa acggcttcaa tggaatgcgc attccgagct 3580501 tgatcatcag aacaccgacg atgacgagaa cgataagccc tgcggcagtt ccgccgatca 3580561 gttcagtgag cgggagcttc ccgacaagcc cgatgaaaaa gatgaccgtt tcgagacctt 3580621 ctcttacaac tgccagaaat gcaatgagcg caaaggaaag caggcttcgt ttttttagtg 3580681 cctgtgactt ctggatattg attttttctc tccatttatc cattgaggcg tttctgtgca 3580741 gccacacccc gacatacaaa agcatgacag cggacagtac gccggtaacg ccgccaagca 3580801 agaaattgtt ttctccgaat acactggagg agaacagaac cgtgacaccg atgccggctg 3580861 ctaaggaaac agccatgccg gcggacgccc cgccccagat ccatgtcgag gaacgcgtaa 3580921 cccgcgcttt ttttgtcatg gttaatagcg ctccgatgac aaggagggcc tccattcctt 3580981 cacgaaccgg gatcagcgcc gcatcccacc agctgtagct gcttgaagcg atcggctcga 3581041 gcaattgaat catttcgtca atttgctttg ataccttttc aggatggctg ccgatctccg 3581101 ccttcatcag cgccagattt tcctccgatg tcgtataggc ttctttcgat tgggacacga 3581161 catctccctc aacagcgagc caggatgtaa ctaaattgtc gattgcggat gacgcttcat 3581221 ccaattgttt tttttctatg aactgttttg tgtctttcaa gctttgtata taggctgtta 3581281 aggacgccct tgattgacct gaggatgtct ttttcagcac gacagcctgc tgataggttt 3581341 ctaaatgaga cgcaagctct tcaagctgtg ttttgagctt acgtgcgtct tgattgataa 3581401 aagaaagaga aatcatcgcg atattcgcgt ccatttcact gtgagaagaa aggttttctt 3581461 tcttaataga aggttcttct tttttccact tcgccttgaa ggtgtcaaac gtttgttgtg 3581521 ccgaatccat atccccgtct tttacggatt tgatcatttg cttgtttaat tgaattaatg 3581581 cggcgatcgg atcatcttcc gcatgtgccg cagaaccgaa aaccatcaac aagctgaata 3581641 gaataagtgc cagcccccga gccatcatgt tcctcctata attgaaaatg attatcattg 3581701 tataacataa tcatagccag ttcctgtcct ttgtcaatta aaatttgaag gtctgaaaac 3581761 cttgatggac agcaaaaaag ctgtcctttt acagaacagc cctttgaagg aaaatgaacg 3581821 attatcttcc tgttttatac gtttgaattt cctcacgaaa cttgcgtgca gcactctcag 3581881 gatcctccgc ctgactgatg gcgctgatca tactgacgcc atcggccccc gcttggataa 3581941 caggtgcggc attatctatt gtgattccgc cgatgccgac aattggaatg ctgatgcctt 3582001 ggcggcgcac tgcttcgata agagatacac cctgtaccgc tctcgtatct tttttcgttt 3582061 cagtcggata gatcggccca agcccgacat aatccgctcc gtcttcttcg gcttgcttca 3582121 cctcagacat cgtatgggca gaaacgccga gaatcatatc acctatggca gctcttacct 3582181 ctttcgcatt tgcgtcttcc tggccgatgt ggataccatc agctttcaga ttcagagcca 3582241 attccacatc atcattgaca atgaacggaa caccagcttc acggcaagct gcctgcgctt 3582301 tttcagcaaa tttaatccga gcctctcctg tcagcgcatc cccgcctttt tcacggaact 3582361 ggtacagggt ggcaccgcct tttaacgctt tttgtacaac tgtaacagga tcggctttcg 3582421 tattgtttga ccccataatg aagtatacag ataataactc tttcatcatt tcccgagaaa 3582481 tacgagtcat gagacagtca ccctttctat agtcgcccat tcttggacgt cttgttcagt 3582541 aacagttgaa agcttgttca gcaattcaat ctgaaagctt ccagggcctt tgtcagccgt 3582601 ctgctgtgcg gcaagctgag cggcgacccc atacgaagaa atggccgcaa tagcagcaaa 3582661 caatggattt tcttccacag cgcaaaacgc accgacgacg gaagtcagca ggcaaccggc 3582721 gcctgtcact tttgtcagca gcttgtggcc gttatgaagg gtgtatacat gtgacgtgtc 3582781 ggctatgaca tcaacttcac cagttatcgc aatgaccgtg tttagctttt gtgccgcctg 3582841 ctgagccagc cggatgatgt cgcctccacc ttcacccgca tcaacacctt tgatcagcca 3582901 atcggtcacg ccgacggtat gggcaatttc cgccgcattt cctctgattg cagcaaggcg 3582961 cacctcacga atgatgtcac gtgccgattc agtgcggaac ggtgttgctc cggcaccgac 3583021 aggatcaaga atgacgggaa cgccatgttc attagctgat tttcccgcga tgatcatcgc 3583081 ttcgactgac tccttgctca gtgttccgat atttaaaacg agtgcacccg caattttcgc 3583141 catatcggcg acctcttctt ttgcgtacgc cataacgggc gatgcgccga gcgcgagcag 3583201 gccgtttgct gtgaaattcg ttacgacatt gttggttatg ctatgcacca gtgggctatg 3583261 ccggcggaca gccgtaagac attttgctgc tgattgtgca tccatatttg catcatcctt 3583321 tactatcttt tttcgggtcc cataaatacg atttcgtatg ttcgagccaa gctctggcgg 3583381 caaacgacaa gtacctgtcc tttctccaaa taatggcgag gtgccaaggg atgaccggat 3583441 cgacaagcgg aatgactttc actttttccg ggtcaaggcc gcggcagatc cgttccggca 3583501 aaagcccgat cccaaggttg gcggatacca tctcactaat aaaatcccat tgtgatgttt 3583561 cataaatgat atggggccgg aacccagcct tgatacattc cgtcataatt cggttgtgca 3583621 ggacaaaatc ctctctgaag aaaataaaag gctcgtcctt caactcacgc agctgacatt 3583681 ctttctcatc agccagccgg tgggaagggt gaacgacaag cattaaggtt tcttttacga 3583741 ttgtaaacga atgaaagata tcttcgtttg cgggaaggac cacaacgccg atatcaagag 3583801 agccgtcccc gacaccttct tggactttta tagaaccgtc ttcgactagc tgaaaggtga 3583861 cattcggata gttttcacgg aaatcgccga gcactctggg gaaaaacccc gatccgatca 3583921 tcggcggcag tccaatccgt acgtgccctt tcttgacttc cataatatca tttaattctg 3583981 acgtcaggtt ttgaaatgat ttaatgattt cctgcgcctg cacatacatg ctatgaccgg 3584041 catcagtcag ttccacctgc ctgccgtttc ggtaaaacag ttcaattccg agctcttctt 3584101 ctaaattttt gatcattttt gatatcgtcg gctgagaaac ataaagggat tgggaagcct 3584161 tcgtaaaact ttttaaacgg gcgacttcca agaaatatgt taaatggcgg atatccatgc 3584221 gcttcaccct ttctatagac aaaaggaata cttcttattc ttaatatata ttttacctat 3584281 agagagacct tatgtacaat aagtatataa gggaggcatc aatatgaaaa aactgttgct 3584341 aaccgttatt caaatcgctc tgttatttat atttgctcgg ctgattaatt gggtgacagc 3584401 ccttcttcat ataaatattc ccggcagtat aatagggatt gtgattcttt tcacattatt 3584461 gcactttaac attatcaagc ttgaatggat cgagcttggt gcagcgtggc ttctcgggga 3584521 gctgctttta ttttttatcc cgtctgccgt cggagtgatt gaatacggag acattatgtc 3584581 gaaatttggt gtcagcattc tgcttgttgt catcatcagc acgtttgtcg tgatggtgtc 3584641 tacaggaacg cttacacaac tcatcgcaaa gagaaaggag aaaaagcata cgtgttcatc 3584701 ggaattgtaa gtttgttttt aacggttttg gtgtatttag gagcaaaaaa ggtatatcaa 3584761 cgctttccgc gtgtttatac gtcgccgcta ttggtgacgc ccgctgtatt agtcggtctg 3584821 ctgctgctgg tgaatgtccc gtacgagtcc tataatctcg gcggcggatt gctgaccgat 3584881 atgctacagc cggccaccgt ggcattcgcg atcccgttat ataaatattt ccctgtttta 3584941 aagaaatacg cagtggaaat tattttgaat gtggccgtcg gttcatgcat cgcgattatt 3585001 tctaccgctc ttattgcgaa atggcttcac ctcggcaccg gcttaattga cagcctcgtc 3585061 ccaagatcag tgacaacgcc gatcgcgatg aacgtatctg aaatgatcgg cggtatgcct 3585121 gccgtcacag ccgtgtttgt gattttaacc gctttgctcg gcacagtgat cggcccgatg 3585181 gtcatccgtt atttccgcat tgataacgaa attgcgcggg gcgtgctgct tggcacaagc 3585241 gcgcacggag cgggaacgtc aaaggcattt gagctcagct ctgtgtccgg cacgatttcc 3585301 agcgtgtcga tgatcttagc tgcgattatg acgctttgcg cggcgccgtt tttgctttca 3585361 tttatgtaaa aaactgtcct ctcgagggca gtttttttta tgtgcttccc cttattgaaa 3585421 agctggcgaa ttccaatata atgtatttgt ggataccaaa ggaggcaccc tgatgcacaa 3585481 cttgcaggtg aggcggcatt atgccgcgtt aaaaggattt tatttgtttg cttttctcgg 3585541 tacgggcagc ataattccct tactcagtat gtatttaacg aaggaacagc atttaagcgg 3585601 atcacaggtc ggcttgatca tgtcactggg cccgattgtg atgattttct ttcagccgtt 3585661 ttggggcatg ctgagcgact atacgcaaaa aacgaaaggc ctgctggcgg tttgcacatc 3585721 aatcacaggc atcattggat tagcctatat tgcatttgac agtttccctc tgtttatttt 3585781 gattgcggcc tgttttgcag cctttcaaag cacgattatt ccactttcgg acagcatttc 3585841 actaaggtac acacaagaaa caaacggcaa ctacggcgga atccgcctgt ttggttctct 3585901 cggcttcggt gtcgcggtgt ttgccatggg acaggtgacg aaccagctgt accccattca 3585961 cgtgatcttt atctttggct gtgcctttct gtgcattgct gccatattgg cttcacaagt 3586021 gcccggccag cagaaaacaa caaaggtcaa tatccgcaaa ggattccggg agcttatcag 3586081 caacaaaact ttcctcatct ttatgatcat cacctttacg acatttgctc caaacttagc 3586141 gaacaatacg tatttcagtc tttttctgga caaaagcggc gcgtcacttt ccgctatcgg 3586201 cattttattt ttcatcggtg tcatttcaga aattccattt atgagattcg cccaaacatt 3586261 tatagataaa atggggctgc tcaacgtcat tatgctgtca ggcggagtct cattattcag 3586321 gtgggcgctc tatttcacgg cgccttcact atggatcatt tatgcgacgg tctttcttca 3586381 gggagtggcc atcggtttat ttatcccggc ggcgcttcaa tatgtgaaaa agattacccc 3586441 aagacacgtt gaagcgacgg cgctgaccat gtacgccgcc attggcaacg ggttcggcaa 3586501 ctggttctgc acatttgcag gcgggtacat ttttgactac gtgtcgatct tcgcagtcta 3586561 cttgcttttt ggcattctga gcatagcagg ctttggcctg acattatatt taatgaaggc 3586621 tgaaaaaaac aaacatacac ttcatcagcc ggctgttact tttaaaccat aatgactata 3586681 atgaacaaaa gaaaggatgt gcgttatgaa cgggcaagag cgaaacagca tttcgaaagg 3586741 gttgcaggtt gatattgtat tgaaagcaga tcaaaaaaca ggaaaactga cgagagggac 3586801 agtgaaggat attttgacga aatcaaactt tcatccgcat ggcattaaag tccgtcttga 3586861 agatggccgc atcggccgcg accagcagat cgtttctaca taaaaaaaag ctgcccctga 3586921 acagggcagc tttttcatta ttttttctgc agaaggacca ctttcaggta gttgccttcc 3586981 ggaaatgccg aaatcgtttt gaaatcctcc ggcagcgtaa attcctcaat gatcgtgtag 3587041 cgttcatttg tttctttaaa ggcggcatca ataaagcctt tgaacttctt catgccaaag 3587101 gcgctgctgt ttgtagaggc aacaatgaca cccttgtcag cagtgatggc gatcgtttcc 3587161 ttcagcaggt ttttataatc cttggccgcg ctgaaggtgc gtttttttgt gcgcgcaaag 3587221 gaaggcggat ctagaataat cagatcaaag cgcaaatcct tttttgcagc atatgaaaaa 3587281 tagttaaaaa cgtccatcac tttaatgtcg tgcgcttcgt aatccagctt gttcacgctg 3587341 aattgctcga tcgttttggc aagacttcga tttgccacgt cgacgcttgt tgttttctcc 3587401 gctccgccaa gcgccgccgc cacggagaat gcacccgtat aagaaaacgt atttaaaacg 3587461 gttttccctt ttgcatagcg gtctctgatc gccttgcgca catgtctctg atccaaaaag 3587521 atgcccgtca tggcgccttc attcagatcc accgcgtatt gaatgccatt ctcttggatg 3587581 atgatcggga actcgcccct tctccctttc acgaagtcat catcttcaac gtattgtcca 3587641 gccgtgtcga agcgtttctt ctcgtaaatc gctttataat caagatccat ctcatccaat 3587701 gcggaaatca gcatgtcttt aaaggtgtaa attcccttgc tgtaccattg aatcagcagg 3587761 tagccgtcat aatagtcgat ggtgacgccg ccgacaccgt caccctcacc gttgaacagg 3587821 cggaaagctg ttgtatcttg agcctcaaat agtttggcgc gcgcttgggc cgcttttgtt 3587881 aatttgctga gaaaaaatgc ttggtcaatc tgttcatgtt tattgcgggt aagcgtccag 3587941 ccaacccctt tgttttgcag gccgtaatag ccccgcgcga gaaactcgcc gccgctctca 3588001 gacacgatat caacgaggtc tccttctttc atgtgccccg cactccctgc gagagcttct 3588061 ttttcaataa ggggatagcc tttttttatt ttggcagcgt gtgctttttt tagggtgagt 3588121 agcttcatat atgtcgtcct ctttccgttt gctttctctt atggtaccac aaaacgccaa 3588181 gatgtctgca ttgacagaaa ggaaaggttt ttctacgata gacaaaaaga gttacgagga 3588241 ggagcagcat ggcaaaacga attgaccata caggcatcat ggtaagagat attaacgcgt 3588301 ccatcacatt ttatgaagag gtactaggca tgaaattgaa ggatcgcatc actcacacga 3588361 acggtgtaat cgagcttgct tttcttggct ttgaagacgg cccggaaaca gaaattgaac 3588421 tgattcaagg ctacagcagc gagcttcccg ctgaaggaaa agtgcaccac attgccctgc 3588481 tgacggatga catcgcggct gaatatacaa aagcggaaaa aatgaacgca aaatttatcg 3588541 acgaggagat cacaacactt ccaaacggat accgttattt ctatatcgaa ggccctgacg 3588601 gtgagtggat tgagttcttt cagcggtaaa aataaagaac gtacattttg tgatgtacgt 3588661 tcttttttat ctataccaac tgatatacgt tgactcatcg caaatcatag cttcccagcc 3588721 catacgctca accaattcat ggatgttttt atctttggct aaaaagacat taatgaatga 3588781 gtcatataca ctcataaaca caaaatccat tttctcatca gttaaaacga gctctgttgc 3588841 ggcttcatca agaaccgtcc gcaagttggc ttcagttatg tccaaaacgc cgcggttttc 3588901 cacaatcggt tctgcgtaat aaaaccgatt ggatccgttc gcacctaata cctttaccaa 3588961 actcggaata tgaaaatttg aaatatgatc ctcactggga taatagaggt ctccatttat 3589021 gttttcatgt aacacctcag ccaaatcctc tctcgcgaac tcgtccctta aagcgcctat 3589081 cgacgtcatt aaagccagcg ccagctcagc atgtgtttga aagccgcaag aagacataac 3589141 cttcttccag gaaacagcct tgcctattcc tcttatttca ttatcgtttg gataaatatg 3589201 ttcataatca ttttttcttt ttgcattctc ccatccttca ggcatttgga taaaaggaga 3589261 aaagataaga gcagcagatg agtattcaac tggtacttgt tgtaagattg gtgattcgtc 3589321 atctaaccat atataatcta gcatgcgcac ctcctttaca tattctaaca ttcctttcgt 3589381 ttgaaagaga tgatcagccc tatgacaggc tgatcatcta tcacatcaca tttttatccc 3589441 cagattcaac cgcactctct tcccgccatt tttgatgatc ccatattctg aaaaacggat 3589501 agtagatagc acaggtgatc agcagattta ccagctgcat aactgcgccc gacacctttc 3589561 cgcctgtcgc caggtaacct gatatgagcg gcggcatcgt ccatggcacc gcgattccgg 3589621 ccggtcttgc caccagcccg gtgctcatgc cgatataagt cgcggtaatc gtgaggagcg 3589681 gtgcgatgat aaatgggaca ataaggaggg gattcatgac aatcggcatg ccgaaaatga 3589741 tcggctcgtt gatattaaat agcgcagggc cgattcctaa tcgtccaagc tgcttcattt 3589801 gtttgctgcg ggagcgcaca agcatcgtca ggacaagcgc cagcgtcgcc ccgcttccgc 3589861 cgacattgat ccaaatttga aaaaactgag tcgtaaaaat actcggcagc gcctcgcctg 3589921 cttggaaggc gagacggttg gcatccatcg cgccgtacca aatcggcgcc atgattccgc 3589981 caatgatgga agccccgtga atcccgcacg accaaagcag catctgcaca aattcagcga 3590041 tcaggcttcc gccgagactg ccgccaagga tggaaagcgg tgtgccaagc aggtctccta 3590101 cgacattgtg cagactctga aaaggtgtca tttcaatcag aagacgcgcc agccatacga 3590161 gaagcacaat gataaagccg ggaatcagcg cgacaaatga tttgcttacc gcaggcggca 3590221 caccgtctgg cattttgaag acgatatttt tttgaataat gtaccgatag atttcggttg 3590281 aaaacaaggc gatcagcatg gcgacaaata agcccttgct gccgagcagc gtgatcggga 3590341 ttccgccccc taccatgatg gactccgttg agccatgcgg tgtaaacggc acctcaaacg 3590401 gtgttgccag cagaaatgcg gcaattgaaa tcgctccggc agaaagggca tcgacaccat 3590461 agctttctgc cagccgatag gcgatcccaa aagcggcaat catcgccata atatcaaacg 3590521 aagcgttaac aggatatccg agcttatcgg cccactcgtt cccaaacaca ctcgccatga 3590581 aatcagcata ccccggaatc ggcaagctcg ttaaaatcaa gaagacagac ccgataataa 3590641 tcagcggcat ggtcaggata attccgtcac gcaaagcgct gagatgccgc tgcccggcaa 3590701 ttttcccggc gacaggcatt attttttcct ccatcacccg agtgaatgtg ctcatcttaa 3590761 aaaccccctt ttctcattgc tttgtgaaca acctccgcaa tgttttcttt atcttatttt 3590821 gaaaacgctt acaaattcat ttggaaaatt tcctcttcat gcggaaaaaa tctgcatttt 3590881 gctaaacaac cctgcccatg aaaaattttt tccttcttac tattaatctc tctttttttc 3590941 tccgatatat atatcaaaca tcatagaaaa aggagatgaa tcatgaaaaa catgtcttgc 3591001 aaacttgttg tatcagtcac tctgtttttc agttttctca ccataggccc tctcgctcat 3591061 gcgcaaaaca gcagcgagaa agaggttatt gtggtttata aaaacaaggc cggaaaggaa 3591121 accatcctgg acagtgatgc tgatgttgaa cagcagtata agcatcttcc cgcggtagcg 3591181 gtcacagcag accaggagac agtaaaagaa ttaaagcagg atcctgatat tttgtatgta 3591241 gaaaacaacg tatcatttac cgcagcagac agcacggatt tcaaagtgct gtcagacggc 3591301 actgacacct ctgacaactt tgagcaatgg aaccttgagc ccattcaggt gaaacaggct 3591361 tggaaggcag gactgacagg aaaaaatatc aaaattgccg tcattgacag cgggatctcc 3591421 ccccacgatg acctgtcgat tgccggcggg tattcagctg tcagttatac ctcttcttac 3591481 aaagatgata acggccacgg aacacatgtc gcagggatta tcggagccaa gcataacggc 3591541 tacggaattg acggcatcgc accggaagca caaatatacg cggttaaagc gcttgatcag 3591601 aacggctcgg gggatcttca aagtcttctc caaggaattg actggtcgat cgcaaacagg 3591661 atggacatcg tcaatatgag ccttggcacg acgtcagaca gcaaaatcct tcatgacgcc 3591721 gtgaacaaag catatgaaca aggtgttctg cttgttgccg caagcggtaa cgacggaaac 3591781 ggcaagccag tgaattatcc ggcggcatac agcagtgtcg ttgcggtttc agcaacaaac 3591841 gaaaagaatc agcttgcctc cttttcaaca actggagatg aagttgaatt ttcagcaccg 3591901 gggacaaaca tcacaagcac ttacttaaac cagtattatg caacgggaag cggaacatcc 3591961 caagcgacac cgcacgccgc tgccatgttt gccttgttaa aacagcgtga tcctgccgag 3592021 acaaacgtcc agcttcgcga ggaaatgcgg aaaaacatcg ttgatcttgg taccgcaggc 3592081 cgcgatcagc aatttggcta cggcttaatc cagtataaag cacaggcaac agattcagcg 3592141 tacgcggcag cagagcaagc ggtgaaaaaa gcggaacaaa caaaagcaca aatcgatatc 3592201 aacaaagcgc gagaactcat cagccagctg ccgaactccg acgccaaaac tgccctgcac 3592261 aaaagactgg ataaagtaca gtcatacaga aatgtaaaag atgcgaaaga caaagtcgca 3592321 aaggcagaaa aatataaaac acagcaaacc gttgacacag cacaaactgc catcaacaag 3592381 ctgccaaacg gaacagacaa aaagaacctt caaaaacgct tagaccaagt aaaacgatac 3592441 atcgcgtcaa agcaagcgaa agacaaagtt gcgaaagcgg aaaaaagcaa aaagaaaaca 3592501 gatgtggaca gcgcacaatc agcaattggc aagctgcctg caagttcaga aaaaacgtcc 3592561 ctgcagaaac gccttaacaa agtgaagagc accaatttga agacggcaca gcaatccgta 3592621 tctgcggctg aaaagaaatc aactgatgca aatgcggcaa aagcacaatc agccgtcaat 3592681 cagcttcaag caggcaagga caaaacggca ttgcaaaaac ggttagacaa agtgaagaaa 3592741 aaggtggcgg cggctgaagc aaaaaaagtg gaaactgcaa aggcaaaagt gaagaaagcg 3592801 gaaaaagaca aaacaaagaa atcaaagaca tccgctcagt ctgcagtgaa tcaattaaaa 3592861 gcatccaatg aaaaaacaaa gctgcaaaaa cggctgaacg ccgtcaaacc gaaaaagtaa 3592921 ccaaaaacct ttaagatttg cattccaagt cttaaaggtt tttttcattc taagaacacc 3592981 acacacaacc tttttcccat ccattgtaca ggcttttcat actattgcta tacagccatg 3593041 aacagcataa aatgaacgtt attacagtta tcaccacata tggcgggatt gtgactgggc 3593101 aggcaggcaa gacccaatga tgcaaaggga gtattaatgc ctaaaaaaca gggcatttta 3593161 actcttcttt tcgtgttggg ctcataacgg cgccttggac aaccccctat tctcatgctc 3593221 cgtcgtcgac gcgggcattt ttgtcatttt cagccggtat ttctcacttt tttcattttg 3593281 attgtcaact tttcatttga tacgatgaac aagccgactt ttcttcagca aaggaggttt 3593341 taattgcttg cataaagaga ttgcaaaaga attactgctg ctcgcaggag gaaaaaacaa 3593401 tattatcagc atcagccatt gtacgacccg tcttcgtttt gatgtaaagg acgagacgaa 3593461 aattgatata catgccattg agaacctgca aggtgtgcag ggcacctttt tccgctatgg 3593521 gcttttccag attatcttcg gagcaggcgt cgtcaacaaa atatataaag aagtcgttca 3593581 tgtatgggag accgcgcctt ctgaagagcc tgtccaccag aaaaaagcca gccggaagct 3593641 gaaccctgcc gcagcttttg cgaaaacact gtccgatatt tttgtgccga ttattccggc 3593701 aataacagca agcggcctgc tcatggggct gatcggcatg attaaggtgt ttcattggtt 3593761 cgctgccggc agcccatgga ttaaaatgct cgacctcgtg tccagcacag cctttatttt 3593821 actgccgatt ttagtcggct tcagtgctgc acggcaattt ggcagcaacc catacctagg 3593881 ggcagtgatt gcagggcttt tgacgcatcc tgatctgctg gacccgtcta tgctcggcag 3593941 caaaaccccg tcttctttag acatatgggg gcttcatatc ccaatgatgg gctatcaggg 3594001 ttccatgata ccgattcttc tttccgtttt tgtcatgagc aaaattgaga agctattaaa 3594061 atcgattgtg ccgaagtcgc ttgatgtcgt gatcattccc tttattacgg tcatggtgac 3594121 agggtgcctc gcgctgattg tgatgaatcc cgccgcgtcc atcatcggcc agatcatgac 3594181 acaatcgatc gtctatattt atgatcacgc cggcattgct gccggagctc ttttcggcgg 3594241 catctactcc accatcgtcc tatctggatt gcatcatagc ttttatgcaa ttgaggcaac 3594301 gctgcttgct aatccgcatg tcggtgtcaa ctttttagtg ccgatatggt cgatggcgaa 3594361 tgtggcccaa ggcggagcgg ggcttgcggt attcctcaaa acgaaacaat caagcctgaa 3594421 gaaaattgcg ctccccgctt ctctgaccgc gtttttaggc attgttgagc cgattgtatt 3594481 cggggtaaat ctcaaattga tccgtccctt tatcggagca gccatcggcg gtgctattgg 3594541 cggagcatac gtggttgcgg tacaagttgt ggcaaattcc tacggactga caggcattcc 3594601 gatgatttca atcgtgctgc cgtttggcgc cgctaatttt gttcattata tgatcggttt 3594661 cttgatcgca gccgtctctg cttttatagc tacattgttt ctcgggttta aagaagagac 3594721 agaataactg gatttattcg atttcattca taaaacgggg gatgaaagga caaaaaagct 3594781 atgaaaatta aaagaatctt aaatcataat gctatcgtcg taaaggatca aaatgaagag 3594841 aagattctct tgggtgcagg aattgcgttt aacaaaaaga agaatgatat tgtcgatccg 3594901 tcaaaaatag aaaaaacctt tatcagaaaa gatacacctg actataagca gttcgaagag 3594961 attttagaaa cattgcctga agaccacatt cagatttctg agcaaattat ctctcatgcc 3595021 gaaaaagagc tgaacatcaa aatcaacgag cgcattcatg tcgctttttc agaccatctt 3595081 tcttttgcaa ttgaacgcct gagcaatggg atggttatca aaaatccgct gctgaatgaa 3595141 atcaaagtcc tttatccaaa ggagttccag atcggcttat gggccagagc actgattaaa 3595201 gataaactgg ggattcacat tcctgatgat gaaatcggca atatcgccat gcatatccac 3595261 acagcaagaa acaatgccgg cgatatgaca caaacgcttg atattacaac aatgatccgt 3595321 gatattatcg agattatcga aattcaactg tctattaata tcgttgaaga taccatctct 3595381 tatgaaaggc tcgtgaccca tctccgcttt gccattcagc atatcaaagc aggcgaatcc 3595441 atttacgagc tggacgcaga aatgattgac atcattaaag agaagtttaa ggatgccttc 3595501 ctgtgtgccc taagcatcgg cacctttgtg aagaaggaat acggctttga gtttcctgaa 3595561 aaagaattgt gctacatcgc catgcatatt cagcggttct accaacggtc agtcgcacgc 3595621 tgagacaaac aaaaaacgct tttgatcatc tcaaaagcgt ttttttatct gatttattgg 3595681 ttgatcgccg gattcccaat cgtattccac ttcgtatagg acatgtaatg gaaatactca 3595741 tcgcgatacg gatgttttgt attggagttc caaggctttt ctccgccgca gaagtgcacg 3595801 attgccgggt tttctcttgt ttcattatat tgcttccgcc ctaacagagt cgatggggtt 3595861 ttcagcttta acatgatata ggtttgagcg ttccagcgcg gatgaagttc ataccactga 3595921 tcatacaaga tcgcattcag tgcatcttgg tcatgcagca caagaaagtc ttcgtctggg 3595981 tgttcattga taaagttgat gactttttct gtgatgtttt gctttctcca agactcaaaa 3596041 tcaataatca tgatacctga gttaaaatac ttccctgtat cagtgacgtt catttctttc 3596101 aggcgttcat gctgccccgc atcctcaaca gcggctacgg tgtatggcgc aatgtctaag 3596161 tcccatagct tagaaatatc ctctaggaca agcgcatcac aatcgatgta aatcattcgt 3596221 ttgatgcttt catccttaat taagtcggga atcgaaatgc ggtaatacgc ggcttttgta 3596281 atatggctgc tctcaaccgc atgttcatac atgttggtat ccacttctaa aaactcaatc 3596341 ggcactccga atttcaaagt ggtttcttcc agtctttttt tgttatcagg cttaattccg 3596401 ccatcaatga cgtataattt tacctctctc tcctgatcca tgttagtcaa taaagaaacg 3596461 aacatcccac ctaaatgacg agcataatta tcatctgcgc atgatacgat atgcatgatt 3596521 tcatctttcc tcaatggtat tcatctccct ttttgttgta caagttacat accctttttc 3596581 aaaaaaataa acacgttctc cgacattttt ttaaacagaa tgtgtgatac aacaaaaaag 3596641 gtgtcatttt ttgaagatgc gataaagcca ataaagaatg aaaaagcttg cgattgtgat 3596701 ggcttcagcc gagacgatat accacggcca tggcccgaga acatctaaga gagaggaacc 3596761 gcccggtttt ttcgtcaaat acatataatt cgcgccaagc cagcgatcaa tcagaaaaat 3596821 acagacgccg tacacattaa caagcaggac tgtcacccat aacgagcgct ggcccattct 3596881 gtaggtgcca atcacagcca tcagcagaca ggataaaaac acagacccgt gagaaataaa 3596941 aaagaggata tatcggatat gcggaaatga aaacataccg aggtcaggag tggcaagagc 3597001 ctgaatcgaa ctgccgatgc cgacaaaaaa caaaaacaca aacagctttc tgctttttgt 3597061 cactaacata atagctgaca aatacaccga caggtcacta agctggagag gcaatgaagt 3597121 gcgcaccgac cacctgtccg tggcgaccat ccatatttga tagccgattt gcgaaccaag 3597181 caaaagaaac acaaacagag aacgcaaaaa ccggctggcc ctcggctgct tgacctcatc 3597241 ttggaacaaa aacaacagaa tggccaaaag ggagataatc gctaacgtca ctacatgctc 3597301 tgtcgaaaac agatgaaacg gatcatgctt atagtcggat tgaacatatt tttgcaaaac 3597361 tgcacccccg ttttcgggtt tttgtttatt ttggcgttgt ttgggctttt tttattcaac 3597421 cgatatatgg gcttgaagtt cacaccagac tctgttaaaa ttcgtttcat agctaatgat 3597481 tctgataatt taaggcaggc ctaaaaaatg gaacgttcac atcaacatca gcagcttcgg 3597541 aaggaagaac acgatacact ttctaagctc aaacaaatgc ccgtcgagtc actcaacctg 3597601 gaagccattt cgatcgctac gaatctgtat cggtctgcac aaaggctccg tgtcaaaatg 3597661 gagactgagg ttctttctac ctataacctt tcttggaccg ctttctccat tctttatgat 3597721 ctatgggtat ggggagcgct cgaaacgaga aaaatcgctg agctgtcagg gatatctaca 3597781 gctacagcaa gcaacgtgat caaaacgctc gaaaaaaaga gtttttgccg taaaagcatc 3597841 gacacaagag atcggcgact cgtgtttgtc tcaatcaccg attccggcaa acaagcgatc 3597901 gaagaactct acccggagtt tcacaaaggg gaaacagagc tcattgcggg aatgacgaag 3597961 gacgaacaga aaatattgac agggctgctt agaaaggtag ctgacaatct tcatacaaca 3598021 taagctttga cgggaatcca gtagcggttt gtctccctgt ttcagagagc cggcggtagg 3598081 tgcgagccgg cgcacaggca aacgtgaatt acctccccaa gctttctttg tgaaccttag 3598141 tagcaaagaa cgggaaaccg ttattcgaat gagcggaaga caatgtcttc aaccagggtg 3598201 gtaccgcgtg cattgagcca cgtcccttat tgggatgggc tcttttttgt gtttgtaaaa 3598261 aaggaggaaa aatgatgaga acatttgagc agctcacagc gtcacaacaa aaagaggtag 3598321 aaagacagct tcagctatac atgacaggcg cccacgaagt cataccgccg gaggaattaa 3598381 aggcaaagct cgtgaaatca atttccacgg gcacgccgct taaaattaag ctcggattag 3598441 atccgtctgc accggatgta catttgggcc atacggttgt gttaaataag cttcgccaat 3598501 ttcaagaaaa cggccacatt gtccagctgt taattgggga tttcacagga aaaattggtg 3598561 atccgaccgg aaaatcggca gccagaaagc aactgactga tgaagaagtt cagcacaatg 3598621 ccaaaaccta ctttgagcaa ttcggaaaag tgcttgatcc agaaaaagtc gagcttcact 3598681 ataactcaaa atggctgaaa acattgaatc tagaagatgt cattgaatta gcagggaaaa 3598741 taacggtagc ccgcctgatg gagcgcgacg actttgaaga acgcatcgcc atgcaaaaac 3598801 caatctcact gcatgaattc ttttacccat tgatgcaggg ctatgattct gtcgttctcg 3598861 aaagtgatat tgaattaggc ggaacggatc agcatttcaa tgtcctcatg ggacggcatt 3598921 tccaagaacg atacaacaaa gaaaaacaag tcgtcatcct tatgccgctc ttggaaggct 3598981 tggatggcgt cgagaaaatg tcgaagtcga aacacaacta cattggcatt aacgaacatc 3599041 caaacgacat gtacggaaaa acgatgtcac tgcccgacag cctgatgaaa aagtacatcc 3599101 acttggcgac agacttagag cttgaagaga aaaaacagct cgtaaaagac ttagaaaccg 3599161 gcgccgttca tccgcgtgat gccaaaatgc ttttagccag aacaatcgtc cgaatgtatc 3599221 acggagagaa agcagcagaa gctgccgaac actcgtttaa aacagtcttt caggaaaaca 3599281 gcctgccgga agatataccg gccgtaaact ggaaaggcga aaaaacgata gcgatgattg 3599341 atctgctcgt caagctaaag ctcctctctt cgaagagcga ggcgcgccgc atgattcaaa 3599401 acggaggtgt acgcatcgac ggagagaaag taacagatgt tcacgccaaa gcagagataa 3599461 gagagaatat gatcatccaa gtcggcaaac gcaagttttt aaagctccaa taatctgata 3599521 ttccgaaacg cttatgaccc ttcattcata agcgtttttt tgcaggtata aagcactgtc 3599581 ttttcaaaaa cgctctccat cttgcaggaa actcctttag catcccgaaa tattccccaa 3599641 ccatacattt aggggaggtt tatttttgat gaaaaagctt ttgactgtca tgacgatggc 3599701 tgttttaact gccggcacac tgctcttgcc ggcacagagt gtcacccctg ccgcgcacgc 3599761 tgtacaaata tcaaatagcg agcgcgagct tccattcaaa gcaaaacatg cgtactctac 3599821 catttctcag ctaagtgaag caatcggccc cagaatagcc ggaactgcag ctgaaaaaaa 3599881 gagtgcccta ttgatcgcct catcaatgag aaaattaaag cttgatgtga aggttcaacg 3599941 attcaacatt cctgaccggc ttgagggtac actgtcttca gcaggacgcg atattcttct 3600001 ccaagcggcg tcgggctcag ctccgactga ggaacaaggg ctgacggccc cgctttacaa 3600061 tgcgggattg ggctatcaaa aggactttac cgctgacgcc aagggcaaaa tcgccttgat 3600121 ttccagagga gacctgactt attacgagaa agccaaaaat gccgaagccg ccggagcgaa 3600181 agctgtcatc atttataaca acaaagaaag cctcgtgcct atgacgccaa acctgtcggg 3600241 aaataaagtc ggcattccgg tcgtcggcat taagaaagaa gacggcgaag cacttaccca 3600301 gcaaaaagaa gccaccttaa aactaaaagc attcacaaac caaacctccc agaatatcat 3600361 cggaatcaaa aaaccaaaga acatcaaaca tccagacatt gtgtacgtga ccgcccatta 3600421 cgacagtgtt cctttttcgc ccggagcaaa tgacaacggc tcaggtacct ctgttatgct 3600481 ggagatggcg cgtgtcttaa aaagcgttcc atctgataaa gaaatccgct ttatcgcttt 3600541 cggcgccgaa gagctcggcc tgctcggctc ctctcactat gtagatcatc tatcggaaaa 3600601 agagctgaaa cgaagcgaag tgaacttcaa cttagatatg gtaggcacaa gctgggaaaa 3600661 agcgtctgag ctgtatgtca acacattgga tggccaatct aactatgttt gggaatccag 3600721 ccgtacggct gctgaaaaaa ttgggtttga cagcctgtct ctgacacagg gaggatcatc 3600781 tgatcatgtg ccattccacg aagccggcat tgattccgct aactttattt ggggagaccc 3600841 ggaaacagaa gaagttgagc cgtggtatca tacccctgaa gactcgatcg aacatatcag 3600901 caaagaacgc ctccagcaag caggcgatct tgtgacagcc gctgtctatg aggctgtgaa 3600961 aaaagagaag aaaccgaaaa ccattaagaa acaaatgaag gcgaaagcat ctgacatttt 3601021 tgaagatatc aaataaaaaa agacggcact tgggtgccgt cttttttaat ccacttcttt 3601081 cttaatcccc agcattttct catctaggta atgggcaatc tccgcggctt ctttcagctc 3601141 atctgttaat tgcttaggaa cgtcattgtt caatttataa taaattttat gttcaaggct 3601201 cgcccagaaa tccatcgcga ttgtccggat ttgaatttct gctttgacgt attccacacg 3601261 gttcgttaaa ttcacaggca tctcaatgat taaatgcagg cttcgatagc cattcggttt 3601321 gggtgtctgg atataatcct ttacctttac gattctcaaa tcttcatgct gcttcaacac 3601381 attcacgaca ttataaatgt cagaaataaa ggaacagatg atgcgcacgc cggcaatgtc 3601441 gtgaatatgc tccttcattt ccttcgtcgt aatctcacag ccctttctca ttaacttatt 3601501 cacgatgctt tcaaagcttt ttacacggga ttttgtatgt tcaatcgggt tgtgtccgtg 3601561 aatgaggtta tattcctggc tgataattga gaactttgta tcgagcgcat ctagcgcaaa 3601621 tttataaact aataactcat ttttccaatc ttccattact gtttttaaat cgtccatatg 3601681 tgttacagat aaatccatgt tcgtcatctc ctttaacgga actttatccg ctgtccatgt 3601741 actagacgtc cctgtctgct gcaaggttct atgaattttt ttacaaaatg cggtcgattg 3601801 taacaaaaaa agaccgcatg aaacgagcgg tcttttttat tatcggaaat agctgatcaa 3601861 taatccgatc gagagcagga atccgaaaaa tgtatttgtt tgggctgttg atttcattgc 3601921 gacaatcata ttcatcggca tttcgttctg gacgaagccc ttcactgcct gaaccggctt 3601981 aggcacgctc aaaaagacga caaacagcca tgggcttgcg gcaccggtaa taaccaagcc 3602041 gacaacccag atataagcga cggcaaacga cgcagctaac agagtaacag ctcccttatg 3602101 ccccatcaaa atcgccaatg ttttgcgtcc gccttttttg tcctcttcaa tatcacgaat 3602161 gttgttcgac aggttaatcg cgccgacaag aatcgcaatc gggatggaaa tcaaaatgct 3602221 ctgcatattg atcttatctg tctgaatgaa aaacgaaatc agcacaaaca ccgaacccat 3602281 gcaaatgcct gagaataatt caccgaacgg cgtgtacgca atcggcagcg gcccgcctgt 3602341 atacaggtag ccgatcgcca tgccgacaag gccgatcagc gcaagccacc agctgctgct 3602401 ggcacaaata tagacaccga gcaaaatggc aatcccgtat gaggcaagag ctaattgcaa 3602461 aatcgtttta ggcttcattc cgtggcgtac aatggcccct ccgattccga ctgattctgc 3602521 tgtatctaat ccgcgtttaa aatcatagta ttcattaaat aagttcgtcg cgatctggat 3602581 ccataggcaa gaaaacagca tagccaaaaa cagcagcaga tcaaccttca cataaaacat 3602641 cgccaaaacg gttccgagca gcacaggcac aaacgatgcg gttaacgtat gaggacgggt 3602701 taactgccaa aggatctgcc ccatgctttc tttttgcggc gctgtctgac cctcaccctt 3602761 atttgtttgg ttcatcttcc tcttcctttc tattaaaagg cttacttttt ttcagccggc 3602821 agcttaataa aaaactcctt ttgcttcctt atctatcata atgacttctc ccttatttca 3602881 caagataccg caagaaggcg ttttctttct tattatacgc ttctcgccct gatttcatta 3602941 ggtttctgct ttcacttgaa cgaacaggta cagaaaaatt tttttaagta cattacactt 3603001 tttaaaagtt aaaaagatct tttgactcca ggtatctttt cctttattat gaatcagctc 3603061 gaaacattcc attcttgccc ttgcaggtat aaagattcat tttcaaaaac atacgccgat 3603121 atattaattt gagggagatt agggaaaaaa tgaaactttt tgagcatctg atcgtcaaat 3603181 aatcatgtga ttgtcgaaaa aacgggaagg gaatttttga tatgctgcaa ttaatgaaac 3603241 agctgtatga aaaacccgct gtcaagtgga catgtcatac aggcttttat ttgatgatac 3603301 tgcttgtttt gttttttatg tatggttttc acaccgcgaa taccggttca tatatttata 3603361 acgatttcta attggagaga gaataactat gaaactttta catgctattc aaacacatgc 3603421 ggaaacttat ccgcaaaccg atgccttccg ctctcaaggc cagtcgctca cgtatcagga 3603481 attatgggag cagtctgacc gcgcggctgc cgcgatccaa aaacgcattt ctggggaaaa 3603541 gaaatctcct atccttgtgt acggccacat ggagccgcac atgatcgttt ccttcttggg 3603601 aagtgtcaaa gcgggacatc cttatattcc ggttgacctg tctattccgt ccgaacggat 3603661 tgcgaaaatt atcgaaagct ctggagcaga attgctgatc catgcagcag gactctcaat 3603721 tgatgcagtc ggccagcaga ttcagacagt ttctgcggaa gaactgctgg aaaacgaagg 3603781 cggctctgtc agccaagatc aatgggtcaa agaacacgaa acgttttata tcatttacac 3603841 ttccgggagc acaggaaatc cgaaaggcgt gcagatttcc gctgcgaacc ttcaaagctt 3603901 cacagactgg atttgtgcag actttccagt cagcggagga aaaatatttt taaaccaagc 3603961 gccgttctca tttgatttgt ctgtcatgga cctatatccg tgccttcaat caggcgggac 3604021 tttacattgc gtgacaaagg atgctgtgaa taagccgaaa gtcttatttg aagagctgaa 3604081 gaagtccggg ctgaatgtgt ggacatcaac accttccttt gtgcaaatgt gcctgatgga 3604141 tccgggtttt tcacaggatc tgctgcctca tgcggacaca tttatgtttt gcggagaggt 3604201 tcttccggtt tctgtggcca aagcgctgct tgagcgtttt ccgaaagcga agatttttaa 3604261 tacgtacggc ccgactgaag cgacagtggc tgtcacatcg gttgaaatta cgaatgacgt 3604321 catcagccgc agcgaatcgc ttccagtggg cttcgccaaa ccagatatga acattttcat 3604381 tatggatgaa gagggacagc cgcttcctga gggagaaaaa ggagaaatcg tcattgcagg 3604441 gccgagtgta agccgaggct accttggtga gccagagctg acggaaaaag cgtttttctc 3604501 tcatgaaggc cagtgggcat accgaactgg cgatgccggc tttattcaag acggtcagat 3604561 tttctgccaa ggacgtttgg attttcagat taaacttcac ggctatcgaa tggagctgga 3604621 ggaaatcgag ttccatgtca gacagtcaca gtacgttcgt tctgctgtcg tgattcctta 3604681 tcagccaaac ggaacagttg agtatctgat cgctgctatt gtgcctgagg agcatgagtt 3604741 cgagaaggaa ttccagctga caagcgctat taaaaaagag cttgccgctt ctcttccggc 3604801 atatatgatc ccgagaaaat ttatctatca ggatcacatt caaatgacgg ctaacggcaa 3604861 aattgaccga aaacgcattg gcgaagaggt tcttgtatga cgccttacag ctcgttttta 3604921 ttctttatac tgcttggcat tcttcttctg ccgacgatca ttctcggctt aaacggaaaa 3604981 agatttcaag catacaacat gttcatatct atcattatat tggctttaat tttttcgcac 3605041 gacttacacg gggtcatcgc gctgtgcctg tttacaatat ggcaggtgct cctgatcagc 3605101 ggctatctgg cataccggca gaaagcgaac agcggctttg tcttttgcgg agctgttatc 3605161 gcgtctattc tgcctttatt tctgtcaaaa atatggccgt ttctttcaca cccgcagccg 3605221 catcatccgc cgcataacct gatcagcttt ttagggattt catatttaac ctttaaaggc 3605281 gttcagctga ttatggaagc aagagacgga ctgctgaaag aacagctgcc attgcaccgt 3605341 ctgctgtatt tcatcctgtt tttcccgacg atttcctccg gcccgatcga cagataccgc 3605401 cggttcgtca aggatgaaca gaaggcttgg acgaaagaag aatacgccga cctgctgtat 3605461 acgggaatcc ataaaatctt catcggtttc ctgtataaat ttattatcgg ctacgcgatc 3605521 aatacgtact tcatcatgaa tcttcccgca atcacgcaca ataagattct tgggaacctg 3605581 ctgtacatgt acggctacag catgtattta ttctttgatt tcgccggcta cacgatgttt 3605641 gccgtcgggg tcagctacat tatgggcatt aaatcaccag aaaactttaa taaaccgttt 3605701 atcagtaaaa atattaaaga tttctggaat cgctggcata tgtctctgtc attttggttc 3605761 agagattatg tgtttatgag attcgtattt tggatgacta agaaaaagtg gatcaaaaac 3605821 cgtatggccg tctcaaacat cgggtatttc ctgctgttta tgctgatggg ggtttggcac 3605881 gggctcgcgc cgcaatatat catttacggc ctctatcacg ccgttctgat gacgtgttac 3605941 aactttttcg agaagtggaa taagaaatat aaatggctgc cgtccaaccg ctggacaacc 3606001 attctcgcta ttgtgatcac attccatttc gtttgcttcg ggttttatat tttctcagga 3606061 aaaccatttc atcaccacca ttaaaggaga ttagaaagct atggatttta aacaagaggt 3606121 attagacgtt ttagcagagg tttgccagga tgacatcgta aaggaaaatc ctgatattga 3606181 aatttttgaa gaaggtttgc ttgattcttt tggaacagta gaattgctgc ttgcgattga 3606241 aaaccgtttt gatattttag tgccgatcac tgaatttgac cgggacgttt ggaatacacc 3606301 taacaacatt gtaaatcagc tgtctgagtt gaaataatga aaaagcgttt tttcggtcca 3606361 attattttgg cgtttattct attcgcaggc gccatcgcaa ttccatcttc atggctgaca 3606421 ggcttcatca ccgataagcg tgtgaaagag tcagcaacag ccttgaatcc gagtatgttt 3606481 caagggctat atttacaaga tcagatgctc aaagatccga catatcttcc gatttacggg 3606541 tcttctgagc tttctcggct ggacgagttc cacccatcta attattttca ggtaaacaat 3606601 gagggattca cgccatacct tgtcggcaaa ggcggatccc agtcattgat tcattcttta 3606661 aacttcgctg cccacatgga tcagctgaag ggcaaaaaaa tcgtattcat cgtgtctccg 3606721 caatggttta ttaagcgcgg gtctgatgaa cagcatttcg cgccgaacta ttctgcgctg 3606781 caagggcttg atttggcatt taacgatcag atcgatcctg aaattaaaaa gaaaatgatg 3606841 aaacgcatgc ttcgctttaa ggctgtgcaa aacgatgcca ttctttctga gctgtacaaa 3606901 gcaatggtaa acggtcagac gtggaaagtg aacgcgctga agccggcggc gaaagtgtat 3606961 tacagcatgc tggaaaagaa agatctgtat tattcaacga cagaatcatc cgggccaaag 3607021 cgctatatct cgcagtcagt aaaggataag tcatggtctg aattgaataa actagcggat 3607081 caatcgggca aacgccactc cggttctaac gattttcaca tcgacaaccc tgtctataaa 3607141 aagctgaagc cgaaagtgcc taagctgaaa gggaaaaaca aaggaagatc gtatgcggtg 3607201 tcaccggaat atggcgactt tgaaatgatg ctcgatatcc tgaaggatgc gggcgcagag 3607261 cctatgtttg tcaccattcc tgttaacggg aaatggtacg attacacggg cttcccgaaa 3607321 aaaggacgca ctgactatta caaaaaggta aataaacaaa tcagagcgaa gggcttccag 3607381 gttgctgatt tctcagggca tgaatatgac ccgtatttca tgaaagacac cattcacatc 3607441 ggctggaaag gctgggtgta tgtcgataaa gcaattgacg aattttataa aaccggaaaa 3607501 gtcacttcat cctgagcatc tcataggacg cggctgcata tttcctgcta agatttgtaa 3607561 tagtaaagga atcacagcca acttaattaa gaggtgttac atccaatgaa gatgacaaat 3607621 aatacggttt taatcacagg gggttctgct ggcatcgggc ttgaactggc caagcgcctg 3607681 ctggaacttg gcaatgaagt tatcatttgc ggacgcagcg aagcacgtct tgcagaagcg 3607741 aagcagcagc tcccaaacat ccatacaaag caatgtgatg ttgcagaccg ttcgcagcgg 3607801 gaagcattgt atgaatgggc tttaaaggaa tatccgaact tgaatgttct cgtcaacaac 3607861 gccggcattc aaaaggaaat tgactttaaa aaagggacag aggagctttt tgtggacggt 3607921 gatgaaattg aacttaattt ccaagcgcct gtccatttat ccgccctttt cacacctcat 3607981 ttgatgaagc agcccgaggc ggcaatcgtt caggtcacat ccgggcttgc gtttaacccg 3608041 ttagctgttt atccggtgta ctgcgcaaca aaagcggcac ttcactcgtt ctcgcttacg 3608101 ctcagacacc agctccgcga cacgagcgtg gaagtgattg aaatggcacc gcctatggtg 3608161 gacacgggct taaaccaaaa atcacgcgat aaacaaggcc tgacgtaccg gggcatttca 3608221 tctgaagaat atgttcaata tttcttggac ggcttgaagg aaggcaaaca ggagattaca 3608281 aatgaacgtg ttgaaggtct tcgggatgcc actcgcgccg attatgacag gttattcgag 3608341 caaatgaaca cgcaggagaa ttaatttctc ctgctttttt catatgaatt tcttacaaat 3608401 ttgagcaaac ctattgcgat tatttgttga aggtatacaa tagaatataa ttattttcaa 3608461 ataagtttga taatataaac aatttaacag cagggagatt gaccatgact aaacaaacaa 3608521 ttcgcgttga attgacatca acaaaaaaac cgaaaccaga cccaaatcag ctttcgttcg 3608581 gaagagtgtt tacagaccac atgtttgtaa tggactatgc cgcagataaa ggttggtacg 3608641 atccaagaat cattccttat caacccttat caatggatcc ggctgcaatg gtctatcact 3608701 acggccaaac cgtgtttgaa gggttaaagg cttacgtgtc agaggatgac catgttctgc 3608761 ttttcagacc ggaaaaaaat atggaacgcc tgaatcaatc aaacgaccgc ctctgcatcc 3608821 cgcaaattga tgaagaacag gttcttgaag gcttaaagca gcttgtcgca attgataaag 3608881 actggattcc aaatgcggag ggcacgtccc tttacatccg tccgttcatc atcgcaaccg 3608941 agcctttcct tggtgttgcg gcatctcata cgtataagct cttgatcatt ctttctccgg 3609001 tcggctctta ttacaaagaa ggcattaagc cggtcaaaat cgctgttgaa agtgaatttg 3609061 tccgtgcggt aaaaggcgga acaggaaatg ccaaaaccgc aggaaactat gcttcaagct 3609121 taaaagcgca gcaggtagcc gaagagaaag gattttctca agtactctgg ctggacggca 3609181 ttgagaagaa atacatcgaa gaagtcggaa gcatgaacat cttcttcaaa atcaacggtg 3609241 aaatcgtaac accgatgctg aacgggagca tcctggaagg cattacgcgc aattcagtca 3609301 tcgccttgct taagcattgg ggccttcaag tttcagaacg aaaaattgcg atcgatgagg 3609361 tcatccaagc ccataaagac ggcatcctgg aagaagcctt cggaacaggt acagcagctg 3609421 ttatttcccc agtcggcgag ctgatctggc aggatgaaac actttcgatc aacaacggtg 3609481 aaacaggaga aatcgcaaaa aaactatatg acacgattac aggcattcaa aaaggcgctg 3609541 tcgcagacga attcggatgg acgaccgaag tcgcagcgct gactgaaagc aagtaagaaa 3609601 aaagccggcc cattacaggc cggctttttt tacgcttcaa ttttgttgaa aaactgcggc 3609661 agatacgctt tgtgcgcctc tagcatttcg tctaaaatct gtttggccac agtatcggac 3609721 gggacaagcg ggttaatcgt catggcaagg agcgcagttt gatagtcacc tgtaactgcc 3609781 gcttctgccg cgacacgttc aaaggatttg atttgctgga caaggccgcg gacagacacc 3609841 ggcaagtcgc cgacagcaat tggcttaggg ccggttttcg tcatcacaca gttcacttca 3609901 actgcggaat cgtctggaat actcgctatt gcaccattat tgatcgtgtt caccggctga 3609961 atgtcatgtt tatcattata aatggagctg attaagttac atgctgcatc actgtagtaa 3610021 gctccgcccc gtttttccag ctgcggcggt ttgatcgcaa ggtttggatc tttataaagc 3610081 tcgaacagct ctttttcgac cttctgtacg acttcagcgc gggtgccctc cgtttgtgat 3610141 gcttccagtt cgtgctccag catctctttt gttttaaaat agtaacggtg atagccgcaa 3610201 gggatgacat tgagcgcttt taagaaatcc ggttcccatt cggcgcctga gatatttttc 3610261 atcgtcatcg cgtttttcgg gtcgcccatc gcctcgatga cttgctcctt cacacttacg 3610321 ccgtccaaga aaacatccag cccgaatacc atatggttca gtccggcaaa ttggacttct 3610381 acgcggtcca catctacatc aagcgctttg gctacgccca ttttgatgcc gattggaaca 3610441 ttgcaaagac cgacgacttt cttcaggttg gagtagcgaa gcaaggcttc tgttaccatg 3610501 ccggcagggt ttgtgaagtt aacaagccaa gcgttcgggc aaagctcttc tatgtccttt 3610561 gcgatctcaa ggatgaccgg aattgtgcgc aatcctttaa acagacctcc cgggccgttt 3610621 gtttcctggc ctatcactcc gtattttagc ggaatgcgct catcctttgc tcttgcctgc 3610681 aaaagtccga cgcggaattg ggtcgtgaca aagtctgcgt ctttcagcgc ctttctccgg 3610741 tcgagcgtaa gatgaatgtc aatcgggacg ccagcttttt caaccatccg tttggcgagt 3610801 gtgccgacaa tattcagctt ttcttcgccc tcggggatat cgacaagcca taattcacgg 3610861 acaggcagct catcataccg tttaatgaac ccctccacta gctcgggcgt atagcttgaa 3610921 cctccgccaa tcgttacaat cttcaatcct tttgtcatat gcttgctccc ctttgctcgg 3610981 tgattttttc atataactca atgatctctg cagccatatc cttcactgtc attgcattca 3611041 ttaaatgatc ctgtgcatga accatcagaa gcgtcatttc cgtcttttct ccgcccgctt 3611101 cattttggat cagctctgtc tgataatgat gggcttttga caattcttca gcagcgtctt 3611161 gaagcttttt ccgcgcttct tctgcgtcac cgcttttcgc agcggcaatg gcctccattg 3611221 cggagctcct accgtttcct ccgtgaagga tgatttgaaa aatgatttgt tccatttcct 3611281 cattcacgcg attcacttcc tttctctaca gagccgcttc tttgtcatct gttgctgcag 3611341 gcgtttggac cagctccaga tcgttttctt ctttcagctt ctgcttatcc cacattctga 3611401 agaatggata gtagacaaca aaggacacgg caatattaat ggcttgcatg accgcgcctg 3611461 agacttttcc tcctgtcgcc aagtagcctg aaaagatcgg cggcatggtc cacggcactg 3611521 cgatacccgc cggtttggcg acaaggccgg tgctcattcc gatgtacgtg agtgtcactg 3611581 tgacaagcgg cgtgatgata aacggaagta agagcattgg gttcatgacg atcggcattc 3611641 cgaatataat cggttcgtta atattgaaga tggccgggcc gaccgcaagc ttcccgagct 3611701 gcttcatttg tttgcttcgg gcgcgcagga acatcgtgac aaccagtgcc aatgtggcgc 3611761 cgcttccgcc aatattgacc cagatatcga aaaattgctg ggtgaaaatc ttaggaagct 3611821 cctcaccggc ttggaatgcg atccggttgg catccattgc gccgtaccaa atcggtgcca 3611881 tgacgccgcc aacaatgttt gcaccgtgaa ggccgcaggc ccataaaagc attttgacgg 3611941 cttcggcgac aaggcttcct ccaaggcttc ctcccagaat ggaaagcgga gtccccaata 3612001 aaacgcttac aatattatga aggctttcaa acggtgtcgc ttcaacaatc agccgggctg 3612061 cccaaattag gaagatgacg gcaaagccgg ggattaacgc gacaaatgac ttgcttaccg 3612121 ccggcgggac accgtccggc attttgaaga ctaaattgcg ctggataata aggcggtaaa 3612181 tctctgtgga caccattgcg ataatcatgg cgacaaataa gcctttgctt cccatgagcg 3612241 aaagcggaat cccgccgcca accatgattt ctttcgtcgc gccatccggc ataaacggca 3612301 cttgataagg tgttgctaat aaaaatgccg caagggaaat ggctccggcc gacaaggcat 3612361 caacaccgta tttctcggcg agccggtagg caatgccgaa cgcggcgaca agacccataa 3612421 tttcaaaggt cgcgtcgact gggtaggcca gtttttcaga ccaggagctg ccaaacgttt 3612481 ttgccataaa ctcagcgtat cccgggatcg ggaggttgcc aatgatgagg aaaaaggaac 3612541 cgatgataat caggggcatc gtgaggatga taccatcacg cagcgcctgc aaatgacgct 3612601 gtcccgcaat tcttcccgct ataggcatga ccttttcttc taagatctga ttgactttat 3612661 tcacatagcc cgcccctctc tatgacacat gtccaagctg ttcagctgat ttcagcactt 3612721 ccgccccatt gcacgttcca taatggacgg tattaatgac gtctaccgga accccctttg 3612781 actctcctaa ttttttgagc tgcggaagca tgtaacggac ttgcggaccg agaagcaata 3612841 catccgcttt atcgatatga ttttgtacag aatcgcctga aactgcccaa atggtatagt 3612901 cttttccctg ttcctgcgca cttttttcca tcttgctcac cagtaagcta gtagacatgc 3612961 ctgctgcaca aacgagtaat atattcatgt aaaagacccc ctagagtttg atcaattttg 3613021 taatgtcctg ctgttgctat catcatatta tgaaatcgct ttcataaaca ctcagggttt 3613081 ttccgcaggc aacggaaaaa aggtatatac aggctgtcag ctcagcattt tttggtcaaa 3613141 cacatccgaa agctcttgat atgaacggca tttgatcagc tggttcatcg ccgccgggtc 3613201 atccaaaatg ctgccaagca gtttatacat gctttgtaaa tccgctttgt tctccttttc 3613261 gacacaaagc agacagacaa attgaactcg ctgactctcc caatcgatcg gttttttgag 3613321 cgtacaaacg gcccaaaacg ttgttttcgt ctgcggaaca agcgggtgcg ggatggcaac 3613381 aagattgcca aaacacgttg gcgacatgtc ttctctttca aaaatggaat ctatgatttc 3613441 ttcatcggca aagccgcatt cgaccacttt ctgccctaaa aattgaatca cttcttcttt 3613501 tgagcgcaga tcctcctgaa aaaaaacgag ttcttttttt aggtagcgat tggctttttc 3613561 cttttcatca ctcagaatag attctatttt tgtaaagtca gttccgccta agatggtgtt 3613621 aaccttcagt actggtacag ggagctcttt tttaatcgga atggtgctga tgacaaaatc 3613681 aattgattcg taggacattt gatcaagact ataatactca gccgttccaa gaatatcgag 3613741 ccgcttgccg aaatgggaac gcagtttttc gcgcagaagc tgggcgcttc cggctcccga 3613801 tgcgcataca atgatacagc gtttcggcgg gctttctgtt ttttttcgtt caatcgcggc 3613861 gccaaagtgg agagccaaat atccaatttc gttttcatga atctcaatac ccgtttgttc 3613921 ctttatcacg attccggcaa tgatcccggc ttcaaaagcg agtggataat gttccttgat 3613981 cgctgccagc atcggatttc gaagattcat gccgtatcgg ttgcggctga tcgccggctt 3614041 catatgcagt gccaagccga ttttcagctc tttgtcatgc aggatgccaa gcttcagttc 3614101 acgatcaaca gctttgatca tggcaagtgt cagctgatcg gtttcctctt ctattgaaaa 3614161 tgtgtcctct ccgcattgtg attgtgtcat tcgttttgtg ccaaggagat gcatggtgat 3614221 gtaggccgtc tcgtctttcg gaaacgtaac ggaaagcttt gattccagct cttttacgat 3614281 ggcttctgca gcctggtact ccttttgatg caggatatga tccatatctt tcgggaaaag 3614341 agaaacatag ttttccgttc tgatccgttt acaggcgata gcgatatgga taatgaggtt 3614401 attcagtccc atgttggaca gagggatgcg gtcgtttttc atttttttca agatggcgga 3614461 acggatgatc tcaatttctt cttttggcaa aatatcagcc ttttcattta aaacatctat 3614521 ctccgtttct ctttcatcaa caatgtactc cgccatgcag tacctcatct gcacctcgtc 3614581 cccgcgcagc ttgaagccgt aattcggacg tgtttccatg acgatgcggt aaggcagcag 3614641 acgtttcttt acttccttta aatccgtttg gagtgtagat tttgagataa atagttcttc 3614701 agcaagttca tcgagcttga gataatggtc cgccagcagc agacgtttca taagataggc 3614761 cattctctcc tccggcaata ccggcaggcc ctttttttgc tgaaattcat cttgcagcag 3614821 tgttctgaat acttgctcgt catcaatgcg gagcttgtag ccggagcctc ttacagattg 3614881 tacaaaggca ccgtggccgc ttagcacacc ttgaagttcc tttatatcat tgcggactgt 3614941 ccgcgtcgtt acgtttaatt gcgcggcaaa aaacgaactt gtcaccgggg cttcagccgc 3615001 catcagcaag cgcagaatat cacgtagtcg cccatgaagc atgagaaaaa cctcctaact 3615061 agtagatgca gggattcagt gaataggcag aaaggatgat gaagggatgc gaaatgtata 3615121 taaattctat aatggagaga atggcaagtc aatgaacatc cggaggacta gagggaaaac 3615181 tgacctataa aaaaacagcc gggatcagcc ggctgttcta gatgcggaca tattcttttg 3615241 tttagacgcc ttgcggtcct tcatgatttt tcgaacaatc gggtaaatga ccggcgccca 3615301 tttgataacg gttttgatca tctttttcaa agctccgatt ctcccttctt ttttctcaac 3615361 cattcccctg attgcctctt ccttaaacat gctaacgcga cacgtacctg tttcccgtca 3615421 cccagaaacg ccatggataa tcgcgtgcct ccccgctgtt gtcaatgccg atgcgcgggc 3615481 cggttgaaat tgcttccggt gtgtacccgc tttcgatgta aagcggctgt tccgtgatcc 3615541 agcgtccgta gtcattcatc gtgacgccaa gcgctttcgt cagctttcct ggtccgtttg 3615601 tccattccct cggactcctg cccggccttc tctcctccat taacagctgg ccttcatgcg 3615661 gctcaatcgc cctgattaat actgcttgcg ggacatcctc ttccgccgca acgacattca 3615721 gcaatgtatg ggtgtgcatc acgtatgtat atacccgccc agcttctgca aacatgatct 3615781 cagtccgctt cgtccggcgg ttgttaaagc tgtgggccgc tctgtctcca gcccccatat 3615841 aggcctctgt ttccacaata tagcctgacg ctgtgccttc gtctgtttct tttacaagaa 3615901 ggcagcccag aagcgatggg gcaagctcaa gagcggtttt ttgataaaac gtgatgggca 3615961 gcggattttt ttctctcgtc acgaatcgac ctctcctttt accgattttt gtacattgta 3616021 ccattcccga agcagatcaa aaaaaacggc tgttttaaaa tctttccatt cagggaatat 3616081 tgttaccgtt caaaaaagga gggccaacca ttgaaagatg atcatcaaaa caagcagcac 3616141 caatcaaatg cccaagggag cgaggaagcg ttttctcata agacatccgg gaaaaacgag 3616201 tcagaggata ccttaacgaa taggcagggg catcctgtta ctgacaacca gaatgtgaga 3616261 accgtcggga atagagggcc tacaacactt gagaactatg attttctcga aaagatcagc 3616321 cacttcgacc gggaacgcat cccagagcgg gttgttcatg ccaggggagc aggtgcacat 3616381 ggatattttg aagcgtacgg aagcttcgga gacgaaccga tttcaacata cacaagggcc 3616441 aagctctttc aggaaaaagg caagaaaaca ccggcatttg tccgtttttc aactgtgaat 3616501 catggaaaac actcgcctga aacattgaga gacccgcgcg gttttgctgt aaagctatat 3616561 acagaagacg gaaactggga tttggtcgga aacaacctga aaatcttttt tatccgcgac 3616621 ccgctgaaat ttccggatct tgtacacgca tttcagcctg atccagtgac aaacatccag 3616681 gatggtgaac gtatcttcga tttcatttct caatctcctg aagcgacaca catgatcacc 3616741 ttcttgtttt cgccttgggg cattccggcc aactaccggc aaatgcaggg ttcaggcgta 3616801 catgcctata aatgggtgaa tgaggagggc aaggccgttc tcgtgaaata ccattttgaa 3616861 ccgaagcagg gcatccgcaa cctgacacag aaggaagcag aagagattca agggaaaaac 3616921 tttaaccatg ccacacagga tctatatgac gcgattgaaa atggcgatta tccagagtgg 3616981 gaagtatatg ctcaaatcat gagcgatgat gagcatcctg aactggactt tgatcctctt 3617041 gatccaacaa aactgtggta taaagacgat ttcccatgga aaccgatcgg caaattggtt 3617101 ctgaacaaaa atccggaaaa ctaccatgcg gaagtggagc aagcttcatt tggaacggga 3617161 gtgcttgtcg acgggcttga tttttcagac gacaaattgc tccaggggcg tacgtttgcc 3617221 tactctgata cgcagcgcta ccgtgtaggc gcaaattacc tgcagcttcc gatcaactcg 3617281 ccgaaaaagc atgtcgccac caaccaggaa ggcgggcaaa tgcaatatcg ggtcgataga 3617341 gcagaaggac aaaacccgca cgtcaactac gagccatcca ttatgggcgg gctgaaggaa 3617401 gcgaagcaag acggaaaaga ccatacgccg catgtcgaag gtgatgtaaa gcgtgaagcg 3617461 attgacagaa caaacaactt cggacaggct ggagaaacgt accggagatt tactgaattt 3617521 gagcggaacg aattgattac gaatttggtg aatacgcttt ctacgtgccg aaaagaaatt 3617581 caggatcaaa tgattgagaa tttcacaaaa gctgatcctg actacggaaa acgcgtagca 3617641 gaagggctaa aaaaggtctc cgaaaacaac agcaacgggc cgatcggcac aactgaaacg 3617701 gaacaggctg caaagcaggc tgaacaggag agtcatccgt ctgatccgta ttaacaacag 3617761 cgaacagggc ttttttagaa gccctgtttt tttatttttc tattgaaacg ctttcaataa 3617821 ttgtgttgta cttggaagga aaggggtgga gagatacgat ggaattacag caggacttga 3617881 ttcctcagaa aaaaacaatc ggcgctttag atcacgccgt ttttttatgc atggtatttt 3617941 gtttctggtt ttcaggctat atttacgttc ctgtattcag tctgtatttg gaggatctgc 3618001 acttttcata tggcgcaatc ggcatcattc tcggcagcta cggggtcacg caaatccttc 3618061 tgcgattccc gctcggcctt ttgtcagaca tcctgttttc cttgcgcaag caattgttaa 3618121 ttgccgggtt cggcttttcc gtcctcagca gcctgctttt tctgatgttt gattctttct 3618181 tcttcgtgct ggccgcccgg cttttcgcgg gaatcactgc ttctacgtgg gtgatggcga 3618241 ccattttata cgcacattat ttcaacaatg gcaatgcatc aaaagcaatg ggcatcatgc 3618301 agttttttac cgtcatgcct cagtttgcca gcattgtgtt ctgcgggctc gccgcagccc 3618361 atttagggag gcaggttcct ttttggatgg cgctggcagc ttctgccgca ggtctggtga 3618421 tctgctgctt tattcaggat ccgtctgctc ctcccgcaaa ccgtggcacc attcgtgtca 3618481 atcagtacat caaagataca ttgcggctgc caaagctgaa gcttttcacc atcctgtcta 3618541 tgacggccca tgccgtatta tttatcacag tgtttggttt tacgccgctt tacatgaatc 3618601 agctcggaat gggcgacgcg gagctgcttt gggtgatgag cgcctttttc ctcccacacg 3618661 cagccgccac attaagcttt gtgtttctgc gctttacaag ccgtatcgct tactccgtga 3618721 tgctcattag tttcgctgtc accggggtct gtttgctata tgttcctttt ttagctgcat 3618781 tgttcacggt ttgcatcaca cacgcctgta ttgggctggc gctcggcttc gtttttcctc 3618841 tgctgctaag ccatgtcgtc gaaatcagtt ctgcccgttt aaaaatgtca gtgatggggt 3618901 tttaccaatc attttatgcg ctaggcatct tcctcgggcc ccttcttgcc ggaaaaatcg 3618961 cacagcttat cgggcttgcg ggagtttttt atggagccgg ttctctggca tttgccgcct 3619021 tttttgtgat gctcgcgcaa aaacgtaaca tgatcaatta atagctttca taccgccgga 3619081 agcgccacac agaaaacacg gccagaagca tgatgcacag aatggagaaa gtgagtgacc 3619141 atccgaaaaa atctgcccgc tctccatgaa gaaggatatg ctccgcctgc ttgcaaatct 3619201 cagccggaag ccacttcgca ccatctggaa atagtgaaac agcaaaggaa acggctgctg 3619261 tgagcccgat cccgcaagcc gcagctgctc cgacagaccg gaatatcgta cttccggcaa 3619321 ggccggcggt cacaataaat atcacccaaa gagcgtaaag gccaaggctt gcggcaaagc 3619381 ggctgaatga tgcgtcctca aacagcagcc ggacgtaata gtaagcaagc ccgtatccag 3619441 ctgcaaacga cataatgccg atcacgcttt ggatgagcca tttactcacg atataatggg 3619501 ctgccgtcac aggccgcgac ataatcagcg ctgttacccc ttgatttctt tcattggcta 3619561 cactgcccat cacgctaaag atgaccagag ccatgccaag cgtgttgaat tgagaaagcg 3619621 tgctgaccat cacttcagac ccggagggca tcgtaaaact gattttcatg ccgtcaggaa 3619681 ggttccctcc atgtgcgatg atttccggca tataataaat ggtcagcggc tgtgtcagcc 3619741 cgacgatcat catcgcaatc ggcagccaaa tcagcttgcc gcttttccat ccttccagcc 3619801 actccttctg caatagcgcc atcatcacct tcatgcgtgc accaccttta gatagacgtc 3619861 ttctagagac tccgttttct gttcaaagcg ggtgacggtc aatccctttc ggatacagtc 3619921 acttaataat gaccggccag cgtgtatatc aggcagctcg aaaaccgctt gggacggatt 3619981 cttatagaca atagctgaga cgtaaggctt ctcttcaagc caaccttcca gcttctcttt 3620041 cactgaaagg gtaaaaacgt tcgtttgctg ctgttgtttc agctcctgta actcgccttt 3620101 ccatgaaatc tcaccgtttt tcataatcac cacttgatca cacacctgtt ctgcatcgtg 3620161 caaaacatgt gtagaaaaca gaacggccat atgctttttc agctcccgca tcatgtccag 3620221 cacctcgaac cgtcctgtcg gatcaagcgc agacaccggt tcatccaata tcaaaaactt 3620281 cggtttatgg agcagtgcct gtgccagacc gagtctttgt ttcatgcctc ctgaatagcc 3620341 cccgatcctt ttgtgcgccg cttcgtgcaa accgacaaat tccagcatct cgccgatttt 3620401 ctcttggcat tttctcttcg aaaggccgga cagtctcccc gcaaatgtca aaaattcatt 3620461 tgcggtcatc cacgaataaa aagcaggata ctgcgggagg tacccaatca aacgccgatc 3620521 cagctttttc tctcctaaca gctttatggt tccagaggtt ggcgaaagca gtccggccag 3620581 catttgcaga gtcgtggttt tgccggctcc attaggtcct aatagtgcga cacactcatt 3620641 ttcattcacg tgaaaactga cattctttac agcttcatgg tgcctgtacg atttgcataa 3620701 tgattcaata gacagcatat cggcttacct ttgctttctg ccgacggtga aaaataaaat 3620761 cggcccgata atattgatac atacgatgat tgcagcccac atccactttg gcccgttcgt 3620821 ccgctcttct tttatacagc tgataagggc aaacaccgcc aaagccagct gtaatacaat 3620881 cagcggcaaa atcatttccc aagaaatatt cattgcttga tccccctttt cttccgatcc 3620941 ggcctaatga caaaaaagta ataacaaatc agaggcatcg gtgcttgaat caatccgaca 3621001 atcccccaaa cccatgccat gtgattacgt tttttcgcat caataaataa aaagattccc 3621061 tgcgccaata cgatgagaca agccgcaacc gttatgataa tttctgtttg tgtcatccgc 3621121 gtttcacctc gcattcgccg agatgccttt ttttctcagc cgcaatcaaa atcggcagca 3621181 ccgcaagcac acaaacctga agcacaataa acacagcagg agcttgagtg aaagctaaga 3621241 ttgcagcact cacaaccatc agcgcgcaga atacaaataa aatgatctct tgaagaagtt 3621301 tttttctgta ttcagctttc atttgtgaca gctggtgaag cagttctttt tgattcggta 3621361 tagagggatt ggctgtttga tcaatttttt tccattctga ctttaaatga tcagaaagct 3621421 tttctttatt catcatccca ctcctttctg atttgctgga gccctttatg aactctggac 3621481 tttacagtgc cttctttgat ttgaagcatc accccgattt cagcgtaggt atagccgtag 3621541 taatgcctta ataaaaccgg tgtgcgcagt ttagggtcca gctttgaaaa cagatcgagc 3621601 gtttcgctcc actctgcccc tttcgccgac acgtcccact tgatcttgcg gattgtttcc 3621661 tccgtaactg tctgattccg tttccattct ctctttctct ttttctggtg atcgagatag 3621721 agccgcgatg caatggagat cagccatgtg gagaattttg aacggccctg aaagcttctt 3621781 aaatggatgt accctttcag aaaggtttcc tgaacaagtt cctcgctgag atcggggtga 3621841 agggaaagct ttaacaagta tttatataag aaagaatagt gatagtggaa aagggctgta 3621901 aacgcctcgt cgtttccctc tttcgcctgc tggatcagcc gctgttcttc ttgtgtatcc 3621961 aatgaccgtg atcccccctt ttttgttttt ctgccttatg agacgacacc ggattcaaaa 3622021 gcgttcatct tttttacaat tcttttcagc cattgacaga tcaggcttcc cggccgtttg 3622081 gctgcatatc cttatttgta aaccccctta tagtctgtta agctatgact ttatgtcgat 3622141 ttcaaaaaaa catccaatat ggaggacgat gcattgaaag tagaaaggcg aacgattgaa 3622201 tatattccga atgaagaaag acatggtaaa gcgaaagatt tatttcccgt atggttcggg 3622261 gctaatatgc atatcaccac gttagtgacc ggcacgattc ccgttgcaat gggacttaat 3622321 ctgttttgga gtgttgccgc tattatttgc ggaaccttaa tcggtgccat atttatggct 3622381 tctcattccg cgcaaggccc tcagctaggc atcccgcaaa tgattcaaag ccgtgcccaa 3622441 ttcggcgtaa tcggagcgat tcttcccctc ttcttagtca tgtttatcta ccttggtttc 3622501 ttcgcaagca gcacgattct ggcggccgga accttaagca gctttgttcc catcccggga 3622561 tcatggagca ttataggctt aagtgccgta tgttttttac tcaccatttt cggccatgat 3622621 ttgattcaca aaatgcaaaa aatcctttct tggacctctt ttgctgtatt ttttgctgca 3622681 acgattctca tttttcaatt gccgattccg gcaggcagct ggatacccgg agcgattgat 3622741 ctgccaattt tcctagtggc agtcagcgca gttgcgacgt ggcagcttgc ctacgcgccg 3622801 tatgttgccg attattcaag atatctgcca gttaaaacac cggcttcaaa aacattttgg 3622861 tacagctatg caggtacatc tgtcagctcc atctggatga tgctgctcgg cgcattgctg 3622921 acaacctcac ttcctgactt tacggcaaac tcaggcagcc agattgtcca attgttcggt 3622981 cccttctcgt ttattatgct gatcattgtg ctatttgggc aaatggcaat caatgttttt 3623041 aacctgtatg gggctttcat gtccacgaca acaacgctgg agccgtttct gaaattaaaa 3623101 gtcacgccca aagtcagaat catcatgatc ctgggtgtca cgcttgtcgg cacagtctta 3623161 agcctactgg gacagagcaa ttttatggaa ctgtttttga attttatctt tttcatcagt 3623221 tatttcttaa ttccgtggac ggcaatcaat ttagtcgatt actacttcgt ccgccacgga 3623281 aagtatcaag tcaaagccat gttcgacgta aacgggcctt atggaaaggt caattggatc 3623341 accacaattg cgttcgttct gtctatcttg ctggaaattc cgtttatcaa cacaagcttt 3623401 tacatcggac cgcttgccaa aatgtttggc ggcggagaca tcgcatggat tatcggcttg 3623461 gccgtgcctt ctgtgcttta ctatgtatta atgaaaccgc gtctgaaaaa acgggcgggg 3623521 tatcaagaaa agctgtcttc tctctgaaga cagctttttt atcattcaaa tcgtttccac 3623581 acgcggggca ggatgtcaga tagctcatga gcgagcaacg tatgagcgga gtgctcgtcc 3623641 gtccagagct cggcgcacgc accatgcaaa tagaccgcgt ttaatacggc gtgctttgga 3623701 tcttcatggc agcagagcat ccccaatatc atgcccgtca gcgtgtcacc ggttccgccc 3623761 ttggcgagcg ccccgtttcc ggttggattg agccagcagt ctccatcagg aaacgcgatg 3623821 acggtttggt ttccttttaa cacaatgaca gtctgcagct gagccgccca ttcctttgca 3623881 tattccgctc tttttttctg caattcgttc acgggcaccc ctgtcattcg gaaaaactcg 3623941 cccgggtgcg gcgtgaggat gacggggccc tcccgtttcg gatatgtgcg cttcgccagc 3624001 gctccggcat ccaaaataac aggacaatca gccgtaagca catgatcgac tgcctgctgt 3624061 acgctttccg tttgcggaag gcccggtccg atggcaatgg cccggtacgt ctcttcaagc 3624121 tgagcatccg ccgccttttt ccagccgtca cgccaatagg tcgcctcggg caaaacagga 3624181 acaattagcg ggattacgtt ttctgatgta ccgatgacaa gcttgccgag accgctccgc 3624241 atggccccaa gccctgcaag cagcgctgct cccggcatgt cgtcacttcc agccagcagc 3624301 aaagccgtac cgtacgtgcc tttatggctc tccgcatctc tttcaggaag cgtggccctt 3624361 acatgctctt ccgtccaaaa tggaacattc atctctatcc ctcctctgct ttcttttcct 3624421 atttttcctg tcccttttct ttttcaaaca aaaaagacag ccttttaggg ctgtctttta 3624481 ttttacagga acatcaaggt gatacaggcg gcgatatcgt tcgtttgccg ccagcagctc 3624541 ctcatgggtt ccttccattt ctgttttgcc gttttcgaga aatacgattt tatcggctgc 3624601 ttccactccc gcgagatggt gtgtaatcca taaaatcgtt tttcctttca gcacctcaaa 3624661 caccgtttcc atcaattcac gttcggtaat aggatcgagg ccgactgttg gctcatcgag 3624721 gatgatgatc ggtgtatcct gcagcaaaat cctcgcaagt gcgatccgct ggcgctctcc 3624781 accggaaaaa cggatgccgg tttcttgtac agaggtatga tatccgtcag gcaatgactc 3624841 aatgtagtca tgcagcttga cctgctttgc ggcgcggcgc acatcctcgt cgcttgcttc 3624901 tccgtttccg agcctgatgt tgttcaaaat gcttgtatca aacaggtgcg gtttttgatt 3624961 taacacggcc accgcatccg caatctgatc ctttaacagc gctgtctcca ctccgtttaa 3625021 cgtcacagaa ccggagtccg gtttcaaggc gccttcgatt aatgcaagcg atgttgattt 3625081 cccagagccg cttcggccga gcagcgccat tttttctcct tggcgcagcg taaaggaaaa 3625141 gttgtgcagc acttggctgc tgttgtcata agaaaacgtc acatcacgaa aggccaaggt 3625201 gacatcttga agatcgagaa tttgatcccc tgattcagtt tgtgacgcct ccggctgagg 3625261 agccacattg ttcatgcgtc tgatagaatc ctgatagccc ggcacttcgc ctaaggcatc 3625321 cgaaagcggc aaaaaggctt ccgtcaacgg aaacaccact agcacaaaag cggcaatcat 3625381 cgttttagcg agctcgccgt ccgcttgctg tcccgctgtc caaaacagca tcagcaaaat 3625441 aaggccagcg acaaggcatt gcgcagcaaa gtcccgccat cttgtaaagc gttgtttttt 3625501 ccgttcaagc tcaaaccaat cacgttcctc tttttcataa gcatcaataa aagcatgccg 3625561 gcgtccgctg aacatccagt cgctgacacc catcacagca tctgtcagac ggctgtacag 3625621 cacattccgt ccgcttttca gcttcgcatt cttcgctctc gtcacgagca aagacacaac 3625681 cggaaacaat acaacaagaa caaacaaata cagcgcaagc aatatggcaa acggccaaga 3625741 gaagaagccg agcgctatca ctgacacagc atacaggagc aaggctgaga tcgcaggaaa 3625801 aatcgttttt aagaaagcat cctgcaaatg ctcaatatcc tcagacaaaa tgccgagcat 3625861 atcccccgtg cgaaaacggg aacgcagcat caaagcaccc ggctcaagca tattgtaaag 3625921 gcggacgcgc atgtcagata cgattttcaa aatgatgtga tggccgacga gccgttccac 3625981 atatcgcgac acagagcgcg caatcccaaa ggtgcgcaca gcgacaatcg gcacataaat 3626041 gagcagaatg ttttccggcc ttgtcgccgc tttagaaatc aaaaaacctg aggtgaacat 3626101 gagaaaagca gcagaaaaaa tcgtcaccgc acccaaaaag ataaccagaa cgaacaggcg 3626161 ggcattttgc ttgatatacg gcaaaatcca ttcttctttc ttcatgctct ttcccccagt 3626221 tgtgccttca cgagtttggt atacacaccg tttttctcca gcagttcatt gtgagtccca 3626281 atttccgcaa ccctgccccc gtcaagcacg ataatttcgt ccatatcgag catccagtga 3626341 aggcggtgag tcgcgagaaa gacgagctta tcctcaaata aatccagcat cgtttctttt 3626401 atttcatatt ctgtttcgat atcaagatgg gcggtcggct catccagcag caggatcgga 3626461 cggtttccca aaaaggcgcg ggccagcgcg acacgctgtg cctggccgcc gctgagcgcc 3626521 cggccgcctt ccccgatccg cccctctaat ccgtcaggaa ggttgttcac cagctccgtc 3626581 agtcccgctg aggcagcagc acgtgttgta tcctctgccg aagcgcttgg atggtagaag 3626641 cgaatgttgt tgccaagcgt atcatcaaaa atgtacggat gctggggaat gtaaagaagg 3626701 ttcttctgcc agctgccgtc ctgcaaatgg gaccggcttg taccattaac ctcaatcatc 3626761 ccgccatccg gctctaaaaa tccgccgaga atatcaatta atgttgattt tccggcgccg 3626821 cttgcaccga taatgccgat ttttttcttg cctttgaatg agagatgaat atcagacacc 3626881 gaacggccga ctgacacgcc tgacagcttc agctcatcct gatcggacca agcttcgagc 3626941 tgaagcggcg tctcttcttt aaaaccaggc tgcgacaaaa tctcttgaat ggtttttcct 3627001 gcttcctggc cgttcagcgt tgcatgataa tcattcccca cttcccgcac cggcaaaaaa 3627061 tactcaggcg ccagaataag cgccgttaaa gcagggccaa gcaaaatatc gccgtcaatg 3627121 aggcgcaggc ccagaaatac tgcgactgtc gccaccgaca gcatcgtgaa aaaatcgagg 3627181 gcgaatgatg acaaaaacgc cacccggagt gtgctcatcg ttgccttgcg ataccgctca 3627241 ctcacataga aaatattttt gctgtgtgac ttgctcaaac ctaggaaacg caatgtctcc 3627301 agcccgcgaa gagaatcaac aaaatgattg gaaagtctct gataggattt ccactgacga 3627361 tccgcttttc tctgcgcgac aaggccgagg agaatcataa agatgatcag aatcggcata 3627421 gcagcgacta aaatgatggc tgatgtccga tcctgaaaaa acacataaat gacaactgcc 3627481 gcaggcacaa tcgccatgct gaccattttc ggcagaaaca gctccaggta gcggcggaac 3627541 tggctgatgc cttccatcgc cagcgtcacc atttgccccg tcccctcttt ctttgcaaag 3627601 cgggggccta atcggaacag ctgatcaaga aaacttttcc tcaaatctgc tcctgtccgg 3627661 gcggcgtatt gatagacgat tttctgtcgc gccaccgtca tcccgtgccg ggcgataaaa 3627721 gcgatgagga aaaagccgat caccggtaaa agggaggtaa tgcccttccc gttgaacagt 3627781 ccggttacgg cctcactcag ccactctgcc tgcataataa tggcggctgt ctgaatcaac 3627841 gttaaacaag taatcaaggt gagaatccgc ttcattcctt tatatcgaaa caggtctttt 3627901 cccattaata agtcataggc tccttatggc tgacgcgctt ccggaagaca taatagctcc 3627961 agatctggct gccgatgacg aacggcaata gcgttaatgc tgcaattgac atgactttaa 3628021 gcgaataatc tccagaagaa gcgttagcta ctgttaaatc gtatgcgcta tgaagcgagc 3628081 tgaccattac acgagggaat agggaaataa agatcattcc cacggtcagc gccagaccag 3628141 cgcctgtcat cccaaatgtc cagccgtctt ttttcttacg aataaataca gccgcgagca 3628201 taaagcagat gacaatcaaa acagcgagcg gaatggtaat ctcgccgcgg cgtgtaaaca 3628261 tgtctgtctg atacgcagaa agggccgcga aggcaagaac cgctacaaaa acaacaccca 3628321 ttatcttttg cgccattttc cgggcgcggt tttgcaaatc accaatcgta cgcagcgtga 3628381 taaacattaa tccatgctgg aagcaaagaa gcgttaccgt cacaccgcca agtatagaat 3628441 atacattgat ataatcagat acatgtgcgt gaatgttcat gtcggcatca atcggcatcc 3628501 cgcggaataa tgtcgtgaac agcacaccaa gcacaaacgg aggaattaga ctgccgaaaa 3628561 aaacgaccca gtcccaaacc tttacccatt ttaaatgatc caccttgccg cggaactcaa 3628621 acgcgacccc gcggcccatt aacgcaagca gcactatgac aaacggaatg taataaccgc 3628681 tcagcatcgt tgcataccag tttgggaatg ccgcgaaaat ggcgcctgcg ccagtcaaaa 3628741 gccacacttc attcgcgtcc cagaacggcc cgatcgtgtt gatcagcact ctgcgttcta 3628801 attcattatg gccaagaaaa cgggtcgcca tgccgacccc gaaatcaaag ccttccaaaa 3628861 agaagaatcc tacaaacaat acagcaacga gtataaacca aagatcatga agagatgcca 3628921 tggtatacct cctgactaaa tggatctgtt gatacaggca catcatgatg attatcatgc 3628981 tccgcacctt ttttaatctc acggataaac aagaagacaa gcagtgcacc aagaatcatg 3629041 tacatcacac cgaatgcgat gattgagaat aacaaggaac ccgctgttac gttaggcgac 3629101 acagattgag cggttgtcat taaccccata accgtccaag gctgacgtcc gatttctgtc 3629161 ataatccagc ccgcggagtt tgcaagaaac gggaaggaaa tcaacgcgat catgatgcgc 3629221 aaataccatt tgctgttttc aagcttttta cggcggttta accaaaggcc gcctaacgca 3629281 gcaagaatca tgacaacacc tgctcctacc atgatgcgga agctccagaa tgtcgttttc 3629341 actggcggaa tgtagtcgcc ttttccgtat attttttcgt actcagcctg aagggttttc 3629401 atccctttga cacttccgct gaatttctga taagccaagt agctcaaggc ataaggaact 3629461 ttgatttcat ttgagctttt ttcatttttt gtatcgatcg tcgcaaaagc ggtccaagca 3629521 gcagggtcac cgctgtcttc ccataggcct tcactggcag ccattttcat cggctgtgat 3629581 tccatcaagt gctcagcctg catgtgtccg ctaaggccga cgccaagacc ggcacaaaga 3629641 ccgacgatca ttgcgagttt aaaagattgc ttaaagaacg gcacttcttt tttcttcagc 3629701 agtttaaaag cactcactcc ggcaataaag aaagctccag tggcaagcgc accgaaaata 3629761 acgtgcggga attcaaccca aagctgaggg tttgtaatca acgcgccaaa atcattcatt 3629821 tccgcgcggc cgtttttgat cgtaaagccg accggctcct gcataaagga gtttgctgtt 3629881 aaaatccaga aagatgacat gatcgttccg aatgatacga gccatatgca gagcgcgtga 3629941 attttcttcg gcaggcggtc ccagccaaaa atccataatc cgataaaaat agattccatg 3630001 aaaaacgcca ataatgcttc aatcgcaagc ggagcgccaa atacatctcc gacaaaacgg 3630061 gagtaatctg accagttcag tccaaactgg aattcttgca aaatccccgt tacaacaccg 3630121 actgcgaaat ttattaagaa taagtgtccc caaaactttg ccattttgag atacagctca 3630181 tttttcttta caagataaag agtctccatc aacgcaacca taaacacaag cccgatagac 3630241 atcggcacaa acaagaagtg aaacaacgtt gttgatgcaa attgtatgcg ggctaatacc 3630301 aattcactca tgctttctcc tccatttccg gttaaaactg ttaatttgct cactacttca 3630361 caaatagaac cgagactttg atcagtaatt cacaaaatag acgaaaaaaa tattgctcaa 3630421 tatttcacaa atgtgtcaaa aagtcatcca atatgatgca agattgccag actgaccaaa 3630481 tgacacaatc tctgactggt tcatattaag tactttacaa cgattcattt caaaaataaa 3630541 gcctaaaata cctaaaaagt cccgcactat gtgacggatt tttgtctatt ttgttgctta 3630601 tttatgtcgg ctgctaggat aaatgaccct ttattatcgt acatcaacac atcgttcctt 3630661 gcgaacaaaa tgcttgcccc cgccccagca ctcgagtctc agcattccgt cttaaaccga 3630721 ttttagtcag aatgcctctt ttcatttgaa ccggtaagag gagaaaagtt gaatagtaaa 3630781 tttttaatat attaataatt tcaatttttt agtatactta acatagtgaa caatttcact 3630841 gcatcaagaa taggggaggt ttttcaatgg gagagcttca aacacacatg caattgcaaa 3630901 cggatacaat tcacgaaggg gttcgaaaag agaattggtt tgcgaaagcc atgaatataa 3630961 aagtaggcat cataccgctt cctgtgtatg ccttgctgtt tatattaatc actgtttttg 3631021 ttatgcatca cgatgtaaaa agtgacattt tgacatccat tgccgtcatg gcgtttttcg 3631081 ggtttacctt tgcccaaatc ggcaaatcga taccgattgt tcgttctatc ggcggcccgg 3631141 ccatcctagc tacttttatt ccgtccgctg tcgtgtacta tcacctgctg cctaatgata 3631201 tcgtcaaatc caccacagaa tttacagaaa actcaaactt tctatatttg tttatcgccg 3631261 gtattgtcgt cggaagcatt ctcggcatga aaagagaaac actcgtaaaa gcattcatga 3631321 aaatctttat tccgcttatt gtcggttctg tcacagccgc tattgtcgga ctggctgtcg 3631381 ggacattgct cggactcgga tttcagcata ccctgctgta cattgtcatt ccgatcatgg 3631441 ctggaggagt cggagaaggc gctatcccgc tgtccatcgg atattctgac atcatgccca 3631501 tttctcaagg ggaagcgttt gcacttgttc tgccatcgat tatgctgggc agcttgtgcg 3631561 cgattattct agcgggattg ctgaaccgaa tcggaaagaa aaaaccggaa tggacaggca 3631621 acggcaaagt ggaccgctcc gaagaagagt cccctgcgct ggaggaatct caaagcggac 3631681 agcaaatgtt caacctttct ttatttgcgt caggcggtat ccttgctgtt tctttatact 3631741 tagtcggcat gctcgctcac gattttttcg gttttccggc acccgttgcc atgctgttac 3631801 tggctgttct aatcaagctg ttcagattgg tgcctgcctc aattgaaaat ggcgcgtttg 3631861 gagtgtcccg cttcttttca acagctgtga cctacccgct tctctttgcg attggggtat 3631921 ccatgacgcc gtgggacaag cttgtcgccg cttttaacct cagcaatatt atcacgattc 3631981 tgtctgtcgt tgtgaccatg atggccgttg gcttcttcac tggaaaatgg ctgaacatgt 3632041 atccgattga aaccgccatt attaatgcat gccattctgg gcaaggcggc acgggtgacg 3632101 ttgccatttt aagcgccgct gaaaggcttg agctaatgcc tttcgcccag gtgtctaccc 3632161 gcatcggggg cgcgattaca gtatccttaa ccttattgct gctgcaccag ttttattgat 3632221 ccccgcaagc aagttcttcg tcaaacgaaa gagcttgctt ttttgcatgt ccatgttttt 3632281 gcaagttccc atcccatgct atagtaatag ttggaaatac tagatagaaa ggaatctggc 3632341 atgcctatgg gaactcatct atttctcttt atgcttctcg ggctgggatt ttatttgata 3632401 tcagccctag ctgcaaaact cattccggcc atagacttct ggattgatat tgttctatgg 3632461 gtcggcgctg cggcttacat cttctctcat ctctcattca tggacggcat tgtctcactc 3632521 gcgacaatgt tctactgcta ttggaccgca atggatctca ttgtttcaga gcgtgtggaa 3632581 aaaccttcgg gagactggca ggaaatcgag cttgccaaaa acaaaacacg cctcctgtca 3632641 gacattacgc tgaccgccat tgtgtttgca ggggctgtca tttttttcat ctatggacct 3632701 gacacaagcc ctctcaaata tgtgatcctt ctcggaatga tctccggcgg aggggcactt 3632761 gtgaagcgaa tactgaatgt ttttagcgta aaggtttttt attcagcagc cttagaaaaa 3632821 ttgcatatca gctcacacta tgaaacccgt acatacccgc tttccgattt gaagaacatt 3632881 cagcttgaat caacagcaga tctcttaaag ctccatccgc ttctgacgat gtattcatcc 3632941 cgtttagatt tgacaacaag ctttcagcaa gtcattaaac tgtctcttcc cggcgaaaca 3633001 ctgtttctga cggtgaagga accgcaaaaa tggaaaacaa ttcttcagga atacacagat 3633061 gcagaaaaca atgtggacaa tgtgatttct gttttgccgt tttatcatcg aaaaaatgtg 3633121 aagcggctgc tcggtaagct ttattttgcc gccagcgtaa aaggggtatc cgcttacgcc 3633181 ttattggtgc tcgcgttata cgcattacac gcctctccat gggtcatggc tgttgccgta 3633241 atcctatatt gggtattcaa catgtatatg tcagaccgtg tgttgcgggc ggcgatggac 3633301 gccaagtctt gtcatcatcc gcatgtacag gccgcggccg ataagatttt cagatcggcc 3633361 ggcatttccc atgtccgcat atacgaaacg gagagtgatg attacaacgg aatggcagta 3633421 ggcatgaatg tcgggaggtc aatggtcatc ctgacaagcg ccacactaac acttccacag 3633481 cgtgtcattg aaggcattct ggcccatgag gcgattcata tcaaaaaacg tgacgttctg 3633541 tcatcacagc ttttgcgttt tctatatctt ggagctgtcg tggggatttt cctcttgttt 3633601 gagcagcata tcacccatcc cgaggcccac aaaattgcgc tttgggcttt cattatggca 3633661 atcattatcc tattccagct ctatcaatcc ttttgttcac aatggatgga ggtgcgtgct 3633721 gacaaccttg gcgcatcatt gctggacggc ggttacaaac aaatggctga agccttgaga 3633781 atcttggcgg ttcggcaaga tgaggatata cagaaacaaa gtgcctatag ctctgaagca 3633841 ggtgaagacg agcttcaaat tgattctctc acccgtgata aaagctggtt tttcagattg 3633901 attgattttc agttcgctcc tcatcctcct atgtattggc gtgtcggcac tttattgtca 3633961 aacaaaggac atggggtgct aaagcgctgg ctcagagacc gactgaaaga atcgatcact 3634021 ttgaaatgaa accggtcagc gtttcatccg tataacagat atggtgaaaa aagggagtga 3634081 cgcgaagtga ttgtgatcat cttattgttt atatctatta ttgtttttct ttcagtcatt 3634141 cagccgcagc cctcgaaaaa caaaagccgc cagcaggcgg acagcgggta tttcggttat 3634201 tcagatcata gctcacacca tgatggatgc agcagtgacg gaggtttcag cgattccggc 3634261 tgtggcggcg gagggggcgg cgattaaacg ccgccttttt ttatttcatt gattcgatgt 3634321 acgcaccaaa agccgagcct gacatgcctg gggacacgcg cacacgatgg agggcataca 3634381 ttccctggtc tctcgaagcc gcgcccggtt ctgtcgtcac gcccatttga tagcctgttt 3634441 tttcagcggc cttcagcgtc tcctcattgt agcgccctac cggatagctg atgatggtgg 3634501 tttgctgatg aaacatgttg tcgaacagct ttttcgaatc agccatctca ctttgctgct 3634561 gttgaggcgt taatccgttc agctcaaggt ggtcaatcgt atggctttca atcgatatgc 3634621 cgtgctgtgc catttccttc atttgttcct ctgtcagatg gtgcttatgt ccgatcgatt 3634681 tgccgatcat aaaaatcgtt gccttcatcc cgtacttttt cagcaccgga tacgcatctt 3634741 gataattgtc ggtgtacccg tcatcaaatg tgatcagcac gcacttctca ctcggttttt 3634801 tatcctgcgt cagcatgaga gatgcctctt tcggcgttaa tgtctgatag ccgttatcat 3634861 gaagccactt catatgcgcc tcgaattctt tctttggcac acggaggctg tttcctgaag 3634921 aaatgctgtg gtacatcaaa atcggcagct ttgccggttt ctctgttttg atccatgcgg 3634981 atgtatcgtc ttcttttttc tgaacttgta ctgccttttt ttccggtttc ttttgttccg 3635041 cttttggcat cggctgctct gcattcgcct cttgatcagc acaagccgca agagccaaac 3635101 agctgcccaa aagaaagatg cttaaaaaca atcgtttcat cgttctcctg ctttctgtct 3635161 atttcttcct cctttttcat cggtttgatt ctgagatttt caatagcaaa aaaccggaca 3635221 tgtctccatg tccggttttt ttgatcttat cggattctca cttctgtctc actgtcaaag 3635281 aaatggcctt tattcatatc aaatgcaacc gtcagctcat cgcccgattg aatatcgagg 3635341 cgggcgtcga tccgcgcaat aaagtcttgg ttgtctatct gcgaataaat cataatttca 3635401 gaaccgagca gctctgcaac attaattttc gccttaatcg aagagttctt atatgattcc 3635461 acgacaatca attcatcatg tatatcctca ggacggatgc cgaagatgac ctctttgccg 3635521 atgtagcctt tttcacgcag cactttcatt tttccttccg ggacggttaa tgccgcagaa 3635581 ccgattttga ttaagccatc cgtgagcttt cctttgaaaa aattcatcgc cggtgatccg 3635641 ataaacccgc cgacaaagac gttttcaggg aattcatata catccttcgg cgtcccgatc 3635701 tgctgaattt tcccatcttt catgactaca atccgtgtcg ccattgtcag cgcttctgtc 3635761 tggtcatgcg tcacataaat cgttgtagtc tgcaatctct ggtggagctt aatgatttcc 3635821 gcccgcattt gcaccctcag cttcgcgtcc aggtttgaca aaggctcatc catcaggaac 3635881 acctttgcat cccgcacgat tgcccggccc agcgcaaccc gctgtctctg tccgcctgac 3635941 agcgctttcg gtttacggtg caaatattcc tcaagcccga gaattttagc ggcttcttcg 3636001 actctttttt tgatttcagg cttcggcatt ttccgaagct tgagcccgaa cgcgatatta 3636061 tcgtagaccg tcatatgcgg ataaagcgcg tagttctgaa ataccatcgc gatatccctg 3636121 tcctttggcg ctacatcatt gacccgtttt ccttcaatat aaaaatcacc tttcgaaatt 3636181 tcttcaagtc ctgcgaccat tcgcagcgtc gttgatttcc cgcagccgga cgggccgacg 3636241 aatacgataa attccttatc ggcaatatga aggttaaagt catcaaccgc cggttccttc 3636301 tgatcataaa atttataaat gtgctccatc cgcaattcag ccatctaaca tccccctttg 3636361 ttattgtaaa cgctttctta tattgagtgt aacagcaatt ccctctcgct aaaatgggca 3636421 gcgttcataa aatcacccag ccatttttcg tgcatatttc caatttattc tgaactttca 3636481 ttttgcaggc agataaaata ggcaagaagc gcgcctttgt acgatttgat atctatccct 3636541 gaccgctcaa taaatttatc aatccgatat tgcaggctgt tgcgatgcag atgcagcttt 3636601 ttcgctgtta atgtgacgtt tgagttgttt tcaataaaca gcttaatggt cttccttagc 3636661 tcagattcac ttccaaataa aagctcagct tcttcagaga gcagtgtttc cagtttttct 3636721 ttttctgttt ctaataatag aaaaggaaag atcatctcaa aggtcacact ctgcacctga 3636781 ggcagccgtt tttcagcaaa caggaaatac gcctgttcac gagcgtaatg ttttcgcaga 3636841 cactcatccg gctcgtaaaa tcttccggcg taaaaacgga cactgaagta gaaatcactt 3636901 tcaagaacct tagcgagcga ttccagttcg tccttctccg ccgccgcttc actttcctgc 3636961 tcgacaatca cacctctgtc ctcatggatc cacacaatca caaaagacac cggccaaaaa 3637021 tggcgaaccg cttccgtaaa ggacgtcctt tctattttgc cgaataaatg aaagtgaaca 3637081 aatctcgtcc gtttctttat atacgccggc aattcccctc tggaaaaaag gaacgaaaac 3637141 cacttgtttt cctcaggtga tttcatagac agttgattgc cctcatccgc aggcgtcaaa 3637201 aatgactgca gcaccaatac ttctttttca ctgatctctg ttttcggaat ggagatatat 3637261 ctctgattgc tctcatcaaa aaaacataga cagccttccc ttatgcaaag ctcctcagac 3637321 acaatcgaac cgggataaat agccagcagc gatttcatag agtctcctct cttatgtaag 3637381 gatctgtata ttcagtataa ggcgaaacac acatgttctc cactaaaaaa gagtatatcc 3637441 ggtatagata gacgagaaac tgaaagggaa acctcattcg tttacatatt ggcttcagcg 3637501 gaaatagaag aagacatgca ggaccaaagg agggtcatct tatgagtttc gaaacgttaa 3637561 acaaaagttt tatcaacgga aaatggactg ggggagaaag cggacgtacg gaggacattt 3637621 tgaatccgta tgaccagtct gtgatcacaa cagcatcttt ggcaacgggc aaacagcttg 3637681 aggatgcgtt tgacattgca cagaaagccc aaaaagagtg ggccaagagc acgacggaag 3637741 accgaaaagc cgtgctgcaa aaagcgcgcg gctatttaca cgaaaaccgt gatgacatca 3637801 ttatgatgat cgcccgcgaa actggcggaa cgatcattaa atcaacaatc gagctggaac 3637861 aaacgattgc gattttagat gaagccatga cgtatactgg tgaattaggc ggcgtcaaag 3637921 aggtgccatc cgacattgaa gggaaaacca ataagattta ccgccttccg ctaggtgtca 3637981 tttcatcgat ttctccattt aatttcccaa tgaatctatc catgagatcc attgcgcccg 3638041 caattgcgct gggtaacagc gttgttcaca agcctgatat ccaaactgct atttccggcg 3638101 ggaccatcat tgcgaaagcg tttgaacacg ccggtcttcc tgccggtgtc cttaacgtca 3638161 tgctgacgga tgtaaaggaa atcggggacg gcatgctcac caatccaatc ccgagattaa 3638221 tcagctttac agggtcaaca gcagtcgggc gccacatcgg tgaaatcgcc ggtcgcgcct 3638281 tcaaacgaat ggcacttgag ctcggcggca acaatccatt tgccgttctt tcagatgcgg 3638341 atgtcgatcg tgctgtggat gccgcgattt tcggaaaatt tattcaccag ggacaaatct 3638401 gtatgattat caacaggatc atcgttcatc aagatgtata cgatgagttt gtagaaaaat 3638461 tcaccgcccg tgtcaaacag cttccgtacg gcgatcaaac cgatccgaaa accgttgtcg 3638521 gcccgctgat caacgagcgc caaatcgaga aagcgctgga gatcattgag caggcaaaga 3638581 cagacggcat tgagcttgcg gttgaaggaa aacgcgtcgg aaacgtgctg acgccgtacg 3638641 tctttgtcgg tgcggacaac aacagcaaaa ttgcccaaac ggagctgttt gccccaatcg 3638701 caaccattat taaagctggc agcgaccagg aagcgattga catggcaaat gatactgaat 3638761 acggcctcag ctctgcggtt ttcacttctg atttagaaaa aggcgaaaag ttcgccctgc 3638821 aaattgacag cggcatgacc catgtcaacg accagtccgt caatgattcg ccgaatattg 3638881 cctttggcgg aaacaaagca agcggtgtcg gccgtttcgg caatccgtgg gtcgtcgagg 3638941 aatttaccgt gacgaaatgg atttcgatac agaagcaata ccgcaaatat ccgttctaaa 3639001 tgaaaaaatc cctctgtttc aagtacagag ggatttttct ttatttagat atatccacaa 3639061 acccttcgcc aaacacatcg cgtacgtcat gtacgatcac aaacgctttt ttgtcgcagc 3639121 ttctaatgat ttttttcagc atagacagct cctgtttgtt aatgacgata tacaaaatct 3639181 cttttgactg gcccgtataa tttcccttcc ctgataaaat cgtcacgccc cgatccatca 3639241 aggtatttac ctgctctgca atctcactct tattttctga aatgaccgta atggcttttt 3639301 tcgtattcaa accttcaata atgaagtcca tcactttggt accgatatac agcatcacga 3639361 tcgtaaacat cattttttct gcaccaataa taaaataaga gctaaatact acgattaaat 3639421 caaaaaacaa gagtgcatag ctgatattcc agtctaaata tttattagca attctggcca 3639481 gaatcgcgga accggccgtc gtcccgccga cccggataat catgccgatc ccgactccgg 3639541 caaatacacc tgcgaaaatc gtattaatga tcaattcatc agacggaatg ctccacccat 3639601 gtgtcagatg aagaaaaagc gaatttgccg caaccgcaat gatcgtataa accgttgttt 3639661 ttccatcaag aaacttgtag ccgattaaaa gcaaaaacgc atttaagata aagttcgtga 3639721 caccaggaga ccattgaaac agataataca aaatcagcgt aatcccagtg actccgcctt 3639781 ccccaagatc attgggaatc gcaaataaat taaccgcaag cgcgaagaaa aaagcgccaa 3639841 tcacaagcat aagtacatcc agcattctct ttttcatcac gaaaacactc cttttcattg 3639901 ttctgttcta gcaaataaaa aaacccagga gaacgctctc gaaaaagagc agaaactcct 3639961 gggcttttat cccaccgtgt cataacagcc aagctgctat gtgttttctc tcggtcacag 3640021 tccaatttgc attgcggaac cctagaaaac cactgttttt atcatatcct tttcactttc 3640081 caatattagc attataaggg acggttcgaa ttggttcaag gggtatttgc ggagttttca 3640141 tcagataagc tggaaaaaaa tacgatttat ctattaaaaa agaacagata taaccgataa 3640201 gaaaaaaagc atatatttta caagcgaatg taactataaa tgataataat tataagaaat 3640261 tcataatttt atattgacta agagaaataa tataggcatt atagtacata tgtttcgtac 3640321 attttattac ataggaggaa atataatggc aggaaaacta gtaccctgta aagcttgcgg 3640381 tcaagaaatt gcaaagggtg taaaaaaatg tcctaactgc ggtaaggatc aacgtaactt 3640441 ttttatgcga cataaaatca ttacgtttat tctcgcagtt gttgtcatca ttattatcgg 3640501 taatatgatt ggcggcggag gcggctcaga agccacttcc aaaacatcaa gcagcagcaa 3640561 agcagaaact gaaaaaacat acaatatcgg tgataccgta aaaactgaaa aaactgaagt 3640621 gacggttacg aaggtagagg acagagatac tgtcggtact caatatgttg aaaagaaagc 3640681 atctgaggga ggtacaattg tagctgttca atatacaatt aaaaacgtat ctaaaaagcc 3640741 gattagctct ttttcaattc caactgttaa attagttgat gctgatggta cttcttatga 3640801 ttctgatatt gatgcttctg taaactatgc aactgagaca aaagttgata actctaaaat 3640861 tttgagtgat ctaaatccta atattaaagt aacaggtgta aaagcatttg aagttgacaa 3640921 ggaagcttat gcaaaaggca cttggaaact aaaattcagt aatgatgtta ttgtgaaaat 3640981 caaataacag ctaacaaggg tgcctgttta ggcacccttg ttctttaaaa aaggccttct 3641041 caattgagaa ggcctccatt cttattccgc actcttatac ccattcacat tagaagactg 3641101 ccatctccag gaatcagcac acatttcctc aaggccgcgt ttcgcttccc agcctagttc 3641161 tcgcttggct ttcgcaggat ctgcaaagca tgtggcgatg tctcccggac ggcggtccgc 3641221 aaaacggtat ggaacctctt tccctgacac tttttcaaag gctttgacca tttccagcac 3641281 gctgtagcct gtgcctgttc caaggttgta tgcatcggct cctgtagagt tcaatacttt 3641341 ttccagcgcc ttgacgtggc cttctgcgag atcaacgacg tgaatataat cgcgtacgcc 3641401 tgtcccgtct tttgtcggat agtcatttcc gaatacgctt aattgctcga gcttcccgac 3641461 tgctacctgt gccacatacg gcataaggtt atttgggatt ccgttcgggt cttcaccgat 3641521 ccgtccgctt ggatgcgcgc cgaacgggtt aaagtaacga agcagcgcaa cgctccactc 3641581 attgtcggct gtatgcaaat cacgcaatat ttgttcaagc atgagcttcg tctgcccata 3641641 aggatttgtc gcgcctaatg gaaagtcttc cgtaatcggc gatgtttccg gaacgccgta 3641701 tactgtcgca gatgaactga atacgatttt cttgacgccg tatttctcca tggcctcgca 3641761 taaaataaac gttcctgtca aattgttatg ataatatttg aggggaatcg ccacagattc 3641821 gccgactgct tttaaccctg caaaatgaat cacagcttcg atttcatttt cagcaaaaac 3641881 ggaatctacc gcttcccggt ccaataaatc cgcttcgtag aacgttaaat cttttcctgt 3641941 aatctccttg acacggttca gcgcttcagc tgaactgttg gacagattat caagaacaac 3642001 aatctcgtag ccgctgttca atagttcaac acatgtgtgg ctgccaatgt aaccggcacc 3642061 gccagtaaca agtattgcca tgatgtaaac cctcctaaaa aatgacctgt tttcattata 3642121 tagtgtttag aaccggtcca catccatttt taagaagttt aatcgtttat taatagtttt 3642181 ttcatatttt ttagcttaaa cccttgccag caattcgata gaggtttcag caagaatgtg 3642241 ctctttcatt tcttgataga gctcattcaa gtaaaagccc ggctgaagat tcagctcagc 3642301 atctaaagca tagaccgtca atgtatacgc atgatccttg tcaggcggtg tcggcccgca 3642361 atactggtga atcacctttg gatcgttgct tcccgcaagc ggtgaagcaa agctgttttg 3642421 cccttgtatc atcaagtcct gtctttcctc actcgcatgt tcaggaagct ctccgatgta 3642481 agccggaata ttagccgctg tccagtgaat ccagctgaat ccgcatacgg gaatggcgtc 3642541 atgatcgatg aaagtaagtg cgagcgtctt tgctccggac gggatgtcat caaaatgaat 3642601 tggaaaggat acaaatgggt ttccttctct cttatatttt tcatccgcgt attttgaata 3642661 cttgtcatgt aaatatggat ttgcttctac gtatatgttc atatgaatcc ctctctctat 3642721 tttctcgttc tataggtata ctaaacgaat cgatgtataa tcagtgataa acaaatacgc 3642781 atgtaaacgt aacaatttgt tatggataac ttgcagtgaa ggagatattt catggattta 3642841 aaatggctgc aaacctttat tgccgcagcg gaatcagaga gcttcaggga ggcggctgag 3642901 catctgtatc tcacacagcc tgccgtttct cagcatatga ggaaattgga agatgaactg 3642961 gacatgaggt tgtttttgca tagcggaaga cgagtcgtac tgactgacga aggcaggctc 3643021 tttttgcctt atgccaaaga aatgatccat gtttaccaag ctggaaagca gaaagtcagt 3643081 caatggaaac aggggtacag ccgatcactc acgctggccg tacaccccta cattgcgtcc 3643141 tatatcttgc ctcgctttct gccagcctat atccaaaaac atccgcatgt cgagctttca 3643201 actcatgtgg ctggatctga cgctattaaa caagcggtgg aacacaatga agctgatatt 3643261 ggtttgtcgc ggaaagaccc gaacaccaac actctttatt atcagcatat atgcgaaggt 3643321 acgctttgtc tggcggctcc tttccaagaa agcagaccgg atgctgcatc cgtcttaacc 3643381 cgctatcggc tgctaacgca tgatcatccg tcatatgggg atgccttttt agataacatc 3643441 cgatcacatt acccgtatct tcaaatgatg gctgtcgggc agacggatac ggctgtccac 3643501 atgatgaaag cgggaatggg ggcatctttc ctccctacct acattatcaa acaggaagaa 3643561 gccgaaaaaa agctgatggc tgtcagcacg cctgcacatc tagaattgcc tgcgtcccaa 3643621 acgtttatga tgtggaaaag aaacagcgaa gacattcagc attttcacgc catgttacat 3643681 gactttatgc agcgcgaaca agtatagagc tgaaaaatca atctgccggt tgacgttttt 3643741 ctttcctatt ttcgctatgc ttaatgcaga aaggatttga tgacatggcg atgagccctt 3643801 atatttttat tgtattgatt cttattattt tatcgatgta tcgagaaaga acggtaaagc 3643861 ccgggaagtt gctgatcatt ccactgttgc tcttatgggg cgtatctgca tcgtttcagc 3643921 cggcgtattt tcattccgta ttacatgtgg cgatcagcgg cattttatta ctgatcgggc 3643981 tggcctgcgg gtttggcatt gggaagatgg taaatgtacg gattcacccg gaaaccggaa 3644041 aggtcacttc acgcggctca cttgggagtg ttatcctcat tctagtgata ctttctttgc 3644101 gcatggccgc gagaacatgg ctgcctgaga gcaacgagat gtttattgcc attattcatt 3644161 ctatgttctt cgttcccctc ggcaccatca cagcccgcaa catcatgctt tacaaagcat 3644221 acagacgact gaccgctggc aaagtatcca ttcaataacc gaaagaagga ccagcatgaa 3644281 cggacaaact ccggctcggc actactacaa gaagcttgtg ccgagcctta ttctcatttt 3644341 gaattgcata caatttttat ctcatccaac taaggctgat cccattttgt tagcatttgt 3644401 atttgcggta tacttagcat tcatttggat cattccctat gtggcatcca ctgctgttag 3644461 tttgagcata ttcatcggac tctggctcct gaccgatttc ttttgggctg tttccggcca 3644521 agagcagggt gccgcctatt ttttgattgt atttttaatg atatatgccg cctttagact 3644581 cccttcacgg ctatccttga tcttcacagc atgtttaatt ggaggcaaca tattactcct 3644641 atcctcacaa gggggaagct tgaataccat catcagcaac atctcgatca tgctcggtct 3644701 gtacgtcctc ttctcctcca tgcgtttcag acgagaagcg agaagggagg ctgaacggaa 3644761 tcatgctgaa ttggcaaaaa tgcatgtgca gctggagcat gctcataaag aactccagaa 3644821 agcgcatgca gagctgcagg aggcttctgt tctttcatta aggtacgcgg tccttgagga 3644881 acgtacaaga attgcccgcg acattcatga cagcatcggt cacgagctga cttctgtgat 3644941 tgttcagctt caatcccttc cctatatcct taaaagcagc aaggaggatt cagaaaaagt 3645001 cattcaaaat gtactgagtg tcgccaggga gtgtcttcaa gaagtgcggt ctgttgttca 3645061 ccaaatgggc cgtagtgaat cgatggtggg gcttaccgct ttgcgggggc tcattcatca 3645121 agtggaggaa cggagcggct tgcacgtttc tttagatact gccggactgt cagaagagtc 3645181 ttggcctcca aacgtgagcg aaacgatcta ccgcatcttg caggaagcgc tgaccaatat 3645241 cattcgtcac gctgacgctt ctcatgcggc ggccgtcatt tctaatgaca agtcccatct 3645301 ctatgtcaca atcaccgacg acggacaatt caccggcagc cttacttatg gatttggcct 3645361 gacaggaatg aaagagcgcg cagaaaaagc aggcggttcc cttactttca gtgccgtaca 3645421 gccgagcggc ctgaaaattg agctgtcatt gccgctcatg acaacgaata aggagcaaaa 3645481 agatgaacaa agataaaata cgcgtagcgc ttgccgatga tcagccgctt gtgcgtgaag 3645541 gcttccgcta cgtcatcaac gcacagacgg atatgacggt ttctggcgag gccggcgacg 3645601 gtcacgatat tatagcactc gcaaaacaaa caaaacccga tgtcatcctc atggatgtcc 3645661 agatgccgcg ttgctcaggc atcgaagcgg cgaaagacat tatgtccgca cttccaaata 3645721 caaagatagt cattttaacc acctttgaca cggaagaata cgtatttgaa ggcatccgtg 3645781 cgggcgcagt cggctatctg ctgaaggata cacttcctga ggagttgata gatgcgattc 3645841 gcgctgcggc cagaggcgag gcgattttcc gtacagtcac agctgctaaa atcatcagtg 3645901 agacatttcg ggcgaaacag caaactcatg ccgaagaact ggcagagccg ttcaccaaaa 3645961 gagagcttga ggttcttcag caaatggcct acggactgag aaatgaggat attgctgaaa 3646021 agcttttcgt cagtgaaagc actgtgaaaa cccacgtgca ccgcatcctg caaaaatgca 3646081 atgcccaaga ccggacacag gcagtcgttt ttgccattcg aaacggtatt gtgcaataga 3646141 aatctctcat cccgccatgc taaaataaga caaaggagat gattggaaat gaaagaagaa 3646201 atcattgaac ggtttactac atatgtaaaa gtcgatacac agtccgatga atccgttgac 3646261 acttgtcctt ccacacccgg ccaattgaca ttaggaaaca tgctagttga tgaattgaag 3646321 tccatcggca tgcaggatgc agccattgat gaaaacggct atgtcatggc aactcttccc 3646381 tccaatactg aaaaagacgt gccgacaatc ggctttctcg ctcacgtcga caccgctaca 3646441 gactttaccg gcaaaaatgt gaatccgcaa atcatcgaaa gctatgatgg aaaagacatc 3646501 gttcttaacg aacagctgca ggtcaccctg tcacctgatc aattccctga gctgtccggc 3646561 tataagggcc atacactcat caccacagac ggcaccaccc ttctcggcgc agacaataag 3646621 gccggtatcg ctgaaatcat gacagccatg gattacctca tcaaacaccc tgaaatcaag 3646681 cacggcacaa tcagagtcgc ctttacgcct gatgaagaaa tcggaagagg gccgcacaaa 3646741 tttgatgtga aacggttcaa tgcatccttt gcctacacgg ttgacggcgg gccgctcggc 3646801 gagcttgaat atgaaagctt caatgccgct gccgcaaaaa ttacgattaa aggcaacaac 3646861 gtacatcccg gaacagctaa aggaaaaatg atcaactctg cgaaaatcgc gatgaagctg 3646921 aacagcctgc tgccggcaga cgaagcgcct gaatatacgg aaggttatga aggcttctac 3646981 cacctgctgt cgattcaagg agacgtagag gaaacaaagc tccactacat tatcagagac 3647041 tttgacaaag agaatttcca aaacagaaaa gaaacaatga agcgtgccgt tgaagaactt 3647101 caaaacgaat acgggcaaga ccggattctg ctggatatga acgaccaata ctacaacatg 3647161 agagagaaaa ttgaacctgt catcgaaatc gtcaacattg ccaagcaagc gatggaaaac 3647221 ctcggcatcg aaccgaagat ttcccccatc cgcggcggaa ccgacggatc acagctgtcc 3647281 tacatggggc ttccgacgcc aaacatcttt acaggcgggg aaaacttcca cggcaaattt 3647341 gaatacatct cagttgacaa catggtcaaa gccgtaaatg tcatcgttga gattgcaaag 3647401 cagtttgaag cgcaagcata acgccaaaag ccagtccaaa aaaggactgg cttttttgtg 3647461 tgaaaatgaa acattttaaa cacgtcctcc gtaaaacaag tatcaacaaa tgaggaggaa 3647521 aaacaatgac aaaacatgca atcgctgcca agagtctctt gaaaaaatgg atcatttcca 3647581 ggccgcttaa catgaaaaag aaatccagcc catttcaaaa aatcagaaaa atgttcaaac 3647641 gcttcttcaa ataaaacatc aaatccccta aatacaatcc gtattcaccc gtaccgccca 3647701 aatgctccgt aatttgggtt ttttgtgttc aattccgcaa aatagggtat aaaccaaaca 3647761 agcaagaaaa cagcacccaa aaacaggtaa ttcgaattac gtaaacttag gttaaaagtt 3647821 atataaagga atttatttta tcgtcgatag taactataga accaatcatc aacaagagca 3647881 aacagcgtaa ttcaagacta ttttcaggtc atcaggtaat actgttttag agggacagtt 3647941 tcttgttatt tattgattta gaattttttg aatacttttt ggcattttat ccgtacaata 3648001 gagagtacca aaactttttt tgggaggtat gtaatatgat cctatttatt atcatcgcat 3648061 tatgcggcta tcttcttttt tctttcagca aggacaatcg ccgcaaaccg caaaagacaa 3648121 gccctctgcc agcagccgca cctcatcaca acaacctaat cgaccttgac gccatccgcc 3648181 aaaaacgccg gatgcatctt tcctaattct atatttcaaa cgaaaaggct gctgaatcac 3648241 gcagcctttt aaaattgttt tgatttagag cctgaaacct tttcgccacc tatccgtaat 3648301 ttcatacaag gcaaacccaa aggagacttc agcaatgatc gagttattta tgaaacaaaa 3648361 aatgttctca tttaaagatg catttcacat ttatgaccgg gatgaacaag aaacattcaa 3648421 ggtggagggg cgttttttct cgttaggaga ctcattacaa atgacagact catctgggaa 3648481 aacgctcgtt tccatagaac aaaaactaat gtctttattg ccgcgctatg agatttcaat 3648541 tggcgggaaa acagtttgtg aggtaacgaa gaaagtaacg ttttccaaac cgaaatttgt 3648601 gatttccggg cttaactggg aaatagatgg tgatttatgg agggatgaat tccaactgac 3648661 ggacggggaa aatgtccgga tgtcagtgag caaaaagtgg ctcagttggg gtgattccta 3648721 tcacttgcag attgcatacg aggaagatgt tctgatttgc actgccatcg ctatcgtgct 3648781 tgatatggtt ttatataacg atgaagatga aagtattttc taaaaagcat tgacaattga 3648841 tccaaaagta ataatattaa gataattgaa atctgaatat gaagttgtac cttatcaaga 3648901 gaggtggagg gactggccct atgatacccg gcaaccgctg tttcaaacag aatggtgcta 3648961 aatccttaag aacattgcgt tcttgcagat gaggcggaga tttgatcgtt caagctcttc 3649021 cttacacaaa ggaagagctt tttacatgct taatatttca gaaaagaggc gaataacatg 3649081 gctcaacaaa cgaatgttgc aggacaaaaa acagaaaaac aacgcaaagc acctttccgc 3649141 gccgatcatg tcggcagctt gcttcgttcc gttccggtaa aggaagcccg gcaaaaaaaa 3649201 gcggctggtg agatgacagc ggaacagctt cgtgatatcg aaaatcaaga gatcacccgc 3649261 atcgtggaaa aacaaaaaga aatcggtctc gatgtggtaa cagacgggga attccggcgt 3649321 tcctggtggc attatgactt cctggaaggg cttgacggtg tggaaccgtt catcccggct 3649381 gaggggattc agttccataa cacaaaaacg aaagcgcgca gcatcaaagt gacgggaaaa 3649441 ctcgatttta cgagccaccc agcgctcggt gattatcaat ttttacatga gattgccggt 3649501 aacgcgacgc caaaattgac cattcccagt ccaaatatgc tgttttttgg cgaaaaggcg 3649561 gataaaggga tttatgacga tcaagaggaa tactttcatg atatggccca agcgtacaaa 3649621 aaagcaatca aagccttcta tgatgctggc tgccgttatc tccagcttga tgatacgtca 3649681 tggtctctct tctttgagga caaaggcaga gaggttgtcc gggcgctcgg cggtgatcca 3649741 gaaacattgc cagccatatt tgccaaaaca attaacgatg ccgtcgcaga ccggcctgac 3649801 gatttaacga tcacaatgca catttgccgc ggcaacttcc gctcaacctg ggcggcatca 3649861 ggagggtacg acgctgtagc ggaaacgatt ttggacggct taaaccttga cggccttttc 3649921 ttggaatacg atgatgaccg ctccggaaac tttgatccgc tccgttttgt gaagcgcaag 3649981 gatctgcaaa ttgtgctcgg cttgatcaca tcgaaatacg gcgagcttga aaatcctgag 3650041 gatgtgaaac gccgtatcaa tgaagccgcg cgttttgtca gcttggacca gctatgcctg 3650101 agcccgcagt gcggtttcgc ctctacagaa gaaggcaacc ttctgacaga ggagcagcaa 3650161 tgggcaaagc tgcgccatgt catcgacatt gccaacgatg tgtggagata atctatcatt 3650221 gacagaaata gaaaatgtgt gaataataga tactatcaga aaatttaata aaaaggtttt 3650281 ccttatcaag agaggtggag ggactggccc tgcgataccc ggcaaccgct gtttaacaga 3650341 atggtgctaa atcctttaga gcaatgattg ctcttgaaga taaggttgag attgtcacgc 3650401 aagctcttcc ttatccaaag gaagagcttt tttatatttg aatggaaaga aggaatggac 3650461 aacatgtcac aacaaacaac acccgcagaa caaaaatcac ttcaaagaaa aaaaccgccg 3650521 tttcgcgcgg atcaagtcgg aagcctgcta agatctgagc ccgtcaaaaa agcgcggctg 3650581 caaaaagcgg ccggcgaaat gaccgctgag cagcttcgcc aaattgaaaa cgacgaaatc 3650641 atccgcattg tggaaaaaca gaaggaaacc ggcctgaacg tcgtgacaga cggtgaattc 3650701 cgcagagcat ggtggcactt tgatttcctg gaaaacttag atggcgttga gccgtttact 3650761 cctgagcaag gcattcaatt ccataacgta cagacaaaag cacgcggcat taaagtcaca 3650821 ggcgatatcg acttttcaac tcacccaatg cttgaagatt actcatttct ccatagcatt 3650881 gccggtgacg cgacgccaaa gatgacgatt ccaagtccga atatgctgtt tttccgcgga 3650941 aaactggaaa aggatgaata caaaaacgat tatcaacttt tccagcacga tgtatccaaa 3651001 gcatataaaa aagcgattca agcgttttat gacagaggct gccgctacct ccagcttgat 3651061 gatacagcgt gggccgtttt cttatcagaa aaaggcttaa aacaaatcga agcgttcgga 3651121 acaacgcctg acgagcttcg ccagctgttt gcgaaatcca ttaacgacgc gattgcagac 3651181 cgcccggatg acttgacggt aaccatgcat atttgccgcg gcaacttcca gtccacttgg 3651241 acagcggaag gcggctatga cgcagcagcc gaaaccattt ttgacggctt gaatcttgac 3651301 ggacttttct tagagtatga tgattcacgc tcaggcggat ttgagccgct ccgttacgta 3651361 aaacggtctg atcttcagct tgttcttggc ttagtgacat ctaaattcgg tgagcttgaa 3651421 aatccggatg acgtgaaacg ccgtatcgaa gaagcgtccc gttatgtaag cttagaccag 3651481 ctttgcctca gccctcaatg cggattcgct tcaactgagg aaggcaacaa gctgactgaa 3651541 gaacagcaat gggcgaagct ccgccatgtg gttgagatcg ctaatgatgt ttggaaataa 3651601 gcaaagaaaa aaacacactt gattccctag cggagcaagt gtgtttttta tgtcattgtg 3651661 cggtgtagcc cccatcaagg acgacagcct gcccagtgac gcccttcgcc ttctcgcttg 3651721 ccaaaaacac ggcataatcc gcaatttcct tgacggaaag cagtcgcttt tgcggcacaa 3651781 gcggaaaaat gacttgttca agtacagagt cgtaagggac atttctagtt ttcgatagat 3651841 cgctaagctg attgcgtaca agctgggtat cgacataacc cggacagagc gcattgactg 3651901 ttatgccgtg gggcgcgcct tccagcgccc ctacttttgt gagtccaatg acgccgtgct 3651961 tggcgctatt ataagcggat ttccctgcaa agcccactaa tccattaaca gacgcaatat 3652021 taatgattct gccaaactgc tgttttttca tgatcggaaa aacatgcttc attgcaataa 3652081 agggagccgt cagcatgacc ttgatcagct gttcaaaggt gtctgtcgga aactcttcaa 3652141 tcggagcgac gtgctgaata ccggcattgt tcaccagaat atccaagcgg ccgtattgtt 3652201 tttggatgac gttcaccgta tcagcaactt gcgcttcctt tgtcacatca tacggaatgg 3652261 ccgccgcgtc aaagccttct tctgcaagct tggaggctgc tttttcacat gcttccggac 3652321 ggaggtctga aacgatgacg ctggcacctt cccgggcgaa ttctcttgcg atttcgaatc 3652381 cgattccgcc ggcagcccct gtcaccaaag cgacttgttt tctcatgtca aacaccttcc 3652441 cattaagaat tgagtacaga ctggcttaca gcgaaatcag cttctgtttt ttcataaacc 3652501 tcttcaattg tgacaccatc ctgaagctcc gtcagtgtca tgcggccgtt cacaaaatca 3652561 aatacagcca aatccgtaat cagcctgtgt acgactttct ggcctgtcag cggaagggag 3652621 catgtttttt tcacctttga ttcaccatgc ttattgacgt gctccatgat gacaacgatt 3652681 cgtttcgccc cgttgacgag atccatggcg ccgcccatcc cttttaccat tttgcccggg 3652741 atcatccaat tggccaaatc cccctgctcc gaaacctcca ttccgccgag aatagctaaa 3652801 tcgatatgcc cgcctcttat catcgcgaat gactcagcgc tgtcaaaata agaggcgcct 3652861 gtcacttcag tgatcgtttc ctttcccgca ttgatcaaat ccgcgtcttc cgttccttcc 3652921 agaggatagg ggccaattcc gagcaagccg ttttccgact gaagcatgac gtgaacgcca 3652981 tcgggtatct catttgcgac aagcgtcggc attccaatcc cgagattcac attcatgccg 3653041 tccttgattt cttgtacagc ccgtttgacc attcgttttc tcgcttcctt cacttggcct 3653101 caccctttcc cgatgcttgc tgaactgttc gtttttcaat ccgtttttct tggctcgcgc 3653161 caagcacgac atgctgtacg taaattcccg gcgtatggat gtgatctgga tcgagctctc 3653221 ctgcttccac gatttcttcc gcctcggcaa tcgtgatctt gcctgccatg gcggcaatgg 3653281 gattgaaatt tctcgccgtt ttcctaaaaa tcaaattgcc catggtgtcc gctttccacg 3653341 ctttgacgat cgccacatcg ccggtaatgc ctcgctccag cacataagtc cggccgccga 3653401 atgttttatg ttcttttccc tcggctatgg aggtgccgac gcctgtcgcc gtataaaatc 3653461 ccggtatgcc tgcaccgcct gcacgaattc tctcagcgag cgttccttgg ggaacaagct 3653521 ctacctcaag ctctccgctt aaaaactgcc gctcaaaaat tttattttca ccgacatagg 3653581 aagcgatcat tttcttgatt tgcttgttag ccagaagcaa accaagcccc cagtcatcga 3653641 ctccgcagtt attgctgaca acggttaaat cctttactcc ctgatctctt atagacaaaa 3653701 tgagctgttc agggatgccg cacagcccaa accctcccgc gatcagcgta tccccatcat 3653761 gaatcagttt cgcagcttcc ttgcttgatg acagcacttt tcccatattg atgccccttt 3653821 cgttttcttc tacactagac cagtcaggct gtaaatcgcg atcacagcaa atacggcagc 3653881 cgttttaatg agcgtgatcg caaaaatatc gcgataggat tgccggtggg tcaaacccgt 3653941 cacggccaga agcgtgataa cggcgccatt atgcggcagt gtatccatcc cgcctgatgc 3654001 cattgaaatg acccgatgca tcacctctgg cggaatattg taagcctgaa tcgcctgtaa 3654061 gtattgttct gacatcgcgc ttaacgcaat gcccattcct cccgaagccg agccggtgat 3654121 tcccgccagc gcagttgtcg taacggcgcc atttacaagc ggatcggtaa aagtatgtga 3654181 aattccgctg ctcagcttat gaaaccccgg cagcgcggcg ataatgccgc cgaacccgta 3654241 ctcagcaccc gtattcatag atgccagcaa ggcgccgcca attccttcat tcagcccttc 3654301 cttcaattgg gcaaacacac ttctccaatc aaataatatc gttgtgatga tgccaatcac 3654361 taaagcaatc tccaccgacc aaatagcagc cgctgaagaa atatcaagcc tgccgaactc 3654421 ctttaatcct atggaagaaa aatcaaatcc attcggatac cactttggca ggtaaatggt 3654481 gaaatattta ttcactgcac cgacgagaat aagcgggaca aaggcaagcg cgtgccgaat 3654541 cgggcttttg tccggttcag ccgcggactc aatcgattca ggagcaggag cattctgcga 3654601 atcaaaaccg ccatagcctt cgccagatgc ctgcgctttc ttccgccttg attccaaata 3654661 gagcatccca gctgccagca caatcactgc gcccatcaaa cccagccaag gggcggcata 3654721 aatgtctgtt ttgaaaaacg acgtcgggat gacattttgg atttgcggcg ttcccggaag 3654781 tgcgtccatc gtaaacgtaa aagctcctaa agcaatcgta cccgggatga ggcgttttgg 3654841 tatgtttgct tcttggaaca tgtttttcgc aaaaggatat acagcaaata cgacaacaaa 3654901 caggctgaca ccgctgtacg tcaagacagc acccatcagc acaatggcaa gtatcgctct 3654961 ttttgccccg acaagccgga caattgtttt cgcgattgat gccgcaagcc cggccatttc 3655021 aacgaccttt ccaaaaatag caccgagcaa aaacactggg aaatacagct taataaaacc 3655081 cgccatcttc tccataaaaa ttgatgaaaa aaaaggaagc acatggcttg gatctgtcag 3655141 cagcaccgcg aataacgcgc aaatcggcgc aaacaatatg acagaaaatc cccgatacgc 3655201 cgtaaacatc agcaaaccta acgccaatag aatgatgatc agttccacac acacatcccc 3655261 cgtttccgcg aactagaaag cgtttacaaa aacctgtccg catcggctgt ttccgtcccc 3655321 tttccatatg tacgagaagc gtgggccaac tattccgatt aaaaaaggaa agctcctttt 3655381 ttcggagctt tcctctacca ttcatttcat tcctattagg atatcaacat caaccgtaat 3655441 atcggctgat ttcatctctt tcagcaggct gactcgatct ttcggcgccg accaggcaag 3655501 cggcgtcatc ttgagaagcc agtggatcgc ctgctggtca agcgttttaa catagcgcag 3655561 cctgacagga cggctgtgtg ctgcatttgc tgtaaaacgc tcaactgctg ccgtattgga 3655621 atacgtgcgc cttggtgaat cagtatataa aaattgcctt aattctatta aatagtcgct 3655681 tcgcggcact acttttatga gcatgccatc attcttcagc agtctatgaa actctgcata 3655741 attggacggc gaaaaaatag acagaacaac atcaaattgg cgatcatgaa aaggagcacg 3655801 cgccacatcg gcaaccgccc acatcagatc tttgaatgcc ttagaagctt ttaagatccc 3655861 gtccttcgaa agatctatgc cggttcctat cgctgctttc cctgcataat caaacccgca 3655921 aagcgcattc aaatgagaac cctcaccgca accgctgtcc aagatggtga atgcctcatg 3655981 accagatttg ggatgactga tgagctctgc aatcgcatca tggagcgggt caaaaaaacc 3656041 acattctcca atcagcctgc tcctcgcttc aaaaagctcg gcaccgtaac tggttttgac 3656101 cggcttcgtc agaaagttca cgtagccgtg ccgagataga tcaaatgtat gtcctcgttc 3656161 tgtacaaatc aagcttttcc ctgatgccgc atccatagaa gaatcgcaga gcgggcatcg 3656221 aaacatgctg aaatcaactg ttcgcttcat gataaaaaac accccattca ttcattttta 3656281 gataaatgaa aaaggcatag acaaataaac ctaggcctat ctcaaaaatt ggccaggtct 3656341 ggcagtttgt ctacacctgt cattatctat aacgaatgaa ttggataatc atgaaaaaaa 3656401 ctccctttct gctgtatggg tttccccgtt tccatcatac aacaaatatc caggagctgg 3656461 aaccttatag tgaagaaaaa tcagtactga catgctggta tcccgccaac atcatatcag 3656521 catagcaatc cagcatgttt ttcctttatt ttctcatttt agaatataaa ttttattatt 3656581 gtgaaaatag ttaaaaaggt tgattttcaa aaagtgaaag gataaaatac tgctatcatc 3656641 ttagaaaaag acattcttgt atatgatcag taatatggtc tgattgtttc tacctagtaa 3656701 ccgtaaaaaa ctagactaca agaaagtttg aataaatttg aacgagttga aaaggacaag 3656761 ttcttttctg tttgctctta tttttcacac tttctgcact tccagaattt gtgaaggata 3656821 agagcttttt ttgtttccat aataaccctc ataggagttg ctatcatgta ctttttacta 3656881 aaccttgtcg gtctcattgt gattatggca gttgtattcc tatgttctcc gcagaaaaag 3656941 aaaatcaagt ggcgcccgat cattacgtta attgttctgg aattgctgat tacttggttt 3657001 atgctgggaa caaaagtcgg aagctgggcc atcggtaaaa tcggtgattt cttcacttgg 3657061 ctgattgctt gcgccagtga cggtatcgcg tttgcctttc cgtcagtgat ggcgaatgaa 3657121 acagtagact ttttctttag tgcgcttctt ccaattatct ttatcgtcac attctttgat 3657181 attttaacgt atttcggcat tttgccttgg ctgattgata aaatcggatg ggtgatttca 3657241 aaggcttccc gcttgccgaa attagaaagc tttttctcta ttcaaatgat gttccttgga 3657301 aataccgaag cacttgcggt catccgccag cagcttacgg ttttaagcaa caaccgcctg 3657361 ctcacattcg gtttaatgag catgagcagc atcagcggct ccattatcgg atcttatctt 3657421 tcaatggtgc ctgcgacata cgtgtttaca gccattcctt tgaactgctt aaacgcgctg 3657481 attatcgcaa acctgctgaa tcctgttcac gtgccggagg atgaagatat catctataca 3657541 ccgcctaaag aagagaagaa agactttttc tctacgattt ctaacagtat gcttgtcggc 3657601 atgaacatgg ttatcgttat tttggcaatg gtgatcggat atgtcgcatt aacgtcagca 3657661 gttaatggca ttcttggcgt tttcgtacat ggcctgacca tccagacaat ttttgcttat 3657721 ctgttcagtc cgttcgcatt cctgcttgga ctgccagtgc acgatgcgat gtatgttgct 3657781 cagctgatgg gcatgaaatt agcaacgaac gagtttgttg cgatgcttga cttgaaaaac 3657841 aatctcaaat cccttccgcc tcacaccgtt gcggtggcga cgacattcct gacgtccttt 3657901 gcaaacttca gtactgtcgg catgatttac ggcacgtaca attcgatcct tgacggagaa 3657961 aagtcaacgg tcatcgggag aaacgtgtgg aaactgctcg tcagcggaat tgcggtatct 3658021 ttattaagtg ctgcgattgt cggcctgttt gtgtggtaga aacattgagc catatccctt 3658081 ttcggatatg gctcttttca ttattgataa atagaggctg gcacctgcac atcccggatt 3658141 cccgctgcat aaggccccaa gtcatactgg ccgaagacga tggcgatccc gtttgccgta 3658201 aagtaaaaca ttgtgtctct gtttagggtt atatcctctt tctttacatc agagaaaaac 3658261 agcacatcgt gttttttgat atagctatat aggtaatctc tcgttttgct gacttttgtt 3658321 ttggtgttca gaatctgatc cagcgtcacc cgcttttgtg ctttcaagtc atagttgaag 3658381 gactggacag acgttagacc gtgggcgccc cctgaataga tataattgag tgtttgaatg 3658441 ctgagcttgc ctgccgcatt gtatttgacg ctgaaggatg tttgatattc ccgttttaaa 3658501 gccctgctgt tcgcctgctt ttttgttttt caggtattcc tgatacgatt gttcatgtag 3658561 gctttcagct cttgattgat tttcttttca aacgcggcat tcccgacgtg atgcacttgt 3658621 ggatacgtta actccttgat ctttttgtac gtatgggtgc tgacagtcgg tgttttcgct 3658681 tgaactgctt ttaaagatgg ggccgcatat gcaaatacag aaaaaagcaa gactgcaatg 3658741 cccgcggctt tcagcatgtt attccatttc atacaatcta ctcctttgat gtcgttgttt 3658801 atcattccct tatttaagca atacacactt ttatagactg attaaatcga aagaagtttc 3658861 taggtctaac agcatgattt ttccaataaa aaaagagaca caggatgtct ctttttttac 3658921 tgtttgcgcc cagaaatcgc ttcatgaagg gcttgtgcca aatctgtatt tccgaacatc 3658981 tctaataccg caatgacagt ctggtccgga atgtgctctg cttcgtgttt tggcacgacc 3659041 agatcgtcca tggttttttt caagctttca ttcagctttt gctgcggata cgctttggcg 3659101 tacagctcca tcggatcaag atcatggttc acgcaccact gggcaaacac caaaatcatc 3659161 atattttcat cgcgttcgta agcttcagtg agctgttttt cgttcatttg tcatgctcct 3659221 tatgaaaagt atcttcctta aagatacagg agccgatcaa attcgtctat cccaatggcg 3659281 atgagcagca accgcatcga taaatgcctt gctgaaagcg gtgtagtcag gttcatcttt 3659341 agccgttacg atgcctagcc cctctgttgt cccgacagag gattgaagaa ggtcaattcc 3659401 ttcatttgcc gcaccgatcg ccttgtagtg attgtaagct tctctgataa acgccatcgc 3659461 ttgtttgttg tcttttaact ccagtcctcc tgcggcatag acggcatcat acagaacaga 3659521 atcaaccgtc aggaacgtgc cgctggcctc aagctgctgt ccgctgccgc ttgtcatata 3659581 ccccagattt tgactgatga tatccactgt gattccttct tgctttaagg cttccagtac 3659641 tgtttgcagc tctttttcat gaaatccgtt tccggcgagt acagcgactt ttcttgttga 3659701 cgcggttttc actgtacggg cttggcttaa cgcaggcgaa gtaagaattt ctttagatgc 3659761 tttacgcttc gcgggcgccg ccacgcctac tcctttggcg atttcttctg ctaaatctgc 3659821 atcgacattg ctgaagacat caacgacctg ccgctgtacg tctttgcttt tgaccttccc 3659881 gacctcgaag cagaaagcag aaatgatgtg ctgtttctcc acaggagaca tgctgttcca 3659941 gaaaagcttc gcctgtgagt aataatcgtt gaagctgtcg cttcgctggc ggattttttt 3660001 gccctcgact ttttcctgat agtggacgta gccgccttct tcagctgtcg caggcgacgg 3660061 atcattgttt tgcagtgagt ttttatgata agcgacaggt cccttattga tcgtcatccg 3660121 gtgatagccg tcgtattggt tgttatggaa tggacagacc ggccggttaa tcggaatctc 3660181 atggaagttc gggccgccaa gacggatgag ctgtgtatcc gtataagaga aaagccgccc 3660241 ctgcaatagc gggtcattgg taaaatcgat gcccggcacg acatttcccg ggtggaatgc 3660301 gacttgttct gtttccgcaa acacattatc ctgattgcgg ttcagcgtca tttttccaat 3660361 gatcttcacc ggcacaagct cttccggcca cagcttagtt gggtcaagaa tatcaaaatc 3660421 aaacttgaat tcatcttcct catcaatcat ctgcacgccg agctcgtatt caaccttgcc 3660481 gccgttttca attgtttccc acaggtcacg gcggtggaaa tctggatctt tcccggcaat 3660541 tttttgcgct tcatcccata cgagagaatg cacgccgagc accggcttcc agtgaaattt 3660601 cacgaaacgt gcctttcctt gttcattgac aaaacggaac gtgtgaacgc cgaagccttc 3660661 catcattctg tagctgcgcg ggatgcctct gtcagacatc gtccacatca ccatgtgggc 3660721 agactcaggg ttattggcga caaaatccca aaatgtatcg tgagcagtcg cagcctgagg 3660781 catttcattg tgtggctcag gcttaaacgc gtgaaccaaa tccggaaatt tgattgcgtc 3660841 ctgaatgaaa aacaccggaa tgttatttcc cacaaggtca tagtttcctt cttcagtata 3660901 aaattttgtc gcaaagcctc tggcatcccg caccgtgtct gcggagcctt tagaacccgc 3660961 aaccgtagaa aaacggacaa ataccggtgt cttcaccgaa gggtcctgaa gaaatttggc 3661021 ccgtgtgtat tccgtcattg gttcgtaaac ctgaaaaaag ccatgcacgc caaatccgcg 3661081 cgcatgcaca acgcgctccg gaatcctctc atggtcaaag tgcgtcattt tctcccggaa 3661141 atgaaaatcc tccatcagcg tcgggccgcg aaccccggct tttaacgagt gctcatcctc 3661201 tgacactcgc aagccttggt ttgtcgtcat tttcttcccg ctgttatcgg tcctgtactg 3661261 ctcaagctgc tcgtcctttg agtgttcatt tacacgtttg ttttggtcat cactcatgtc 3661321 tgctccccct ttttaaaacg aaacattcta cagcacattt acccgtggcg ttcttcatat 3661381 aaactgctaa tccgctcatt aggatttttg gtctacatat aaatatgcgg tcatacacat 3661441 ttgaaataag ccttcttcac agaaagaaag gatggaagcg cttaccaaaa aagctgttga 3661501 ataggggagg tcatatcatg cttgccatac tcggttttgt gatgatgatt gtctttatgt 3661561 accttattat gtctaaccgg ctttccgctc ttattgcttt gattgtcgtt cctattgtgt 3661621 ttgccctgat cagcggattt ggcaaagatc tcggcgagat gatgattcag ggcgttacag 3661681 acctcgcccc taccggtatc atgctgttat tcgccatcct gtatttcggc attatgattg 3661741 actcaggcct gtttgatcct ctcattgcca aaatcttatc gtttgtcaaa ggagatccgt 3661801 taaaaatcgc cgtaggcaca gcggttctga ccatgaccat ttcgctggac ggagatggga 3661861 caacaaccta tatgattacc attgcagcga tgctgcctct ctacaaacgg ctcggcatga 3661921 accgtttggt gttagcggga atagcgatgc ttggttcggg ggttatgaat attatcccgt 3661981 ggggcgggcc gactgcgagg gttttggctt ccttaaaatt ggacacgtca gaggtcttta 3662041 caccgctgat tcccgctatg atcgccggca ttctctgggt gatcgccgtt gcttatatcc 3662101 tcggaaagaa agagcggaag cggctcggcg tcatttcgat tgatcacgca ccgtcttccg 3662161 acccggaggc cgcaccgctc aagcgtcccg ctcttcaatg gtttaacctg ctgctgactg 3662221 tcgctctgat ggccgcactg atcaccagcc tgctgccgct ccctgttctt tttatgactg 3662281 cgttcgccgt tgccttgatg gttaactatc caaatgtcaa agagcagcag aaacgaatct 3662341 cggcgcatgc gggtaatgcg ttaaacgttg tctcaatggt gtttgctgcg ggcatattca 3662401 caggcattct ctccggcaca aaaatggtgg atgccatggc gcattctctc gtttcactca 3662461 tccctgatgc catgggcccg cacctgccgt tgatcactgc gatcgtcagc atgcccttca 3662521 cctttttcat gtcgaatgac gccttttact tcggtgtcct tcccatcatc gccgaagccg 3662581 cttccgctta cggaatagac gccgctgaaa tcgggagggc ctccttgctg gggcagcctg 3662641 tgcatctgct cagcccgctt gtgccttcca cctatctatt ggtaggaatg gcaggcgtca 3662701 gctttggcga ccatcaaaaa ttcactatta aatgggccgt gggaacaacg attgtgatga 3662761 ccattgcggc gcttttgatt gggattattt ctttctaaat gtatgagctt gatcgtagca 3662821 ttgagtgagt acgtgattta cagaggggag aagatcaaat aggatattat gagtgaatag 3662881 aagattcatg ccaacaactt ctcattacaa tcataagagc ctgctatatt gcagcaggct 3662941 ctttcacatt tggcattatt tttttgtata gcgcacccag tcataatgag cgtatagcgg 3663001 atttacacca ttgtaggagc caagccattc atcgacaccc gtgccattcc acaagttcat 3663061 catgatcttt ccaggtgttg tcggaatttg gtttgttgca gtatgtttta attgcccgtc 3663121 gacataccat ttaatagagt ttggctgcca atcgaatgca tacgtatgat aggcattggc 3663181 tgcatcaaac ccgagatcaa caatcttctc atggtttcct gcaccatttg tataatagtt 3663241 aaattgaacc ttcgttgtgt cttttcctaa aaattcgata tcaatctcat cccaaggagt 3663301 tccatctgtt ggacctgtgt aagtgaagaa cgatgaaacg atccctgtgt ttttagctgg 3663361 tttcattctg acttcataaa gtccatagcc atatgtttga acagaacggt tttccccgca 3663421 gtcaaacttg ttataagctg ggcttgttag cgctaaacgc atttcaccca atgacgtcat 3663481 tgatacgtta ttagcccgcc acgtgcagtt gaacatattt ccattcgaat aaccatctgc 3663541 tttttgccaa aaaccggagt tatagccgtt aaaagggtca aaaaacgatc cacctgtttg 3663601 agctgaggca gtagcagtga ctgcaaacaa actcataaac aatccagtga caagaagcag 3663661 caacactcgt ttcagataag gcatattggc attccccttt cattgaaagc gttttctatg 3663721 ttgatcttac atgattcttt taaaagggaa catcggtcaa aataatgata atatcgaatc 3663781 ttactaactt gaatcctgta actatcatca tcttccctct gaaaaaaata aaaacctaaa 3663841 ttaccatcag cacagacaga gatgatccgc actcattgca atttaggttt tgcctgcttt 3663901 atcagtaaca atcctaccat tttcatatgt gaatgtaaga aaaagtgaac acaaggaaac 3663961 acaaatgtca gcgctctcat tatgcttgtt taactaccct ttctatgtga atggttaaat 3664021 acagcagctc gtcacttgtg agcttgtgct catactcccg ctcaatgtag gtttggattt 3664081 tcttcgtgca ttcatacgcg cgatgatact tttctttcac tgtatccagc aaaaaatcgt 3664141 cctggctttc catgtgagtg ccgttaaata gacgctgcgc gaaaaacttt aagtgggtga 3664201 cgaaccgata atagtgaagc gattcttcgt tgaattcaat cttaaaatgg tattttacaa 3664261 tactcaaaat ctcttgcatg acttttgtaa tgttgataat attgggcatc tcttcattca 3664321 gctcggcatt tacaatatgc agagcaataa agcctgcttc atcctctggc agagacacac 3664381 cagtcttgtt ttttaccata accaacgctt ctttgccgat cgcaaattcg tctttgtaga 3664441 gccgttttgt ttcccacagc aaggcgtttt tgatatcaag ccctttctgg ttgcgctgga 3664501 tggcaaagtt aatatggtcg gtcagcgaca catagatgct gtcgttgagc tttttgccga 3664561 gctgtaattt tgcgtagctg ataatctctt cggatacttc catacactcg atcggtatat 3664621 catacaaaag ggttttgaac ttttctgata catccttgtt atcgagcgtg aacactttct 3664681 caatgcgggc ttcatcgaca tcatcgccgg actttttctg aaacgcgagc cccctgccca 3664741 tgacgaccaa ttctttcccc tgttcattga ccacgctgat cacattattg ttgatcacct 3664801 tcgcaatttt catggcatgt ccctccaaat ctactaagaa cagactatat cttgattgta 3664861 cattcttttt gtactaggtc aatatcatca gggaaagacg gaagctggtc agtacaattc 3664921 actccgtacc tgctgcccgg gctgtttttg aagcagcgcc tccagatggc gttcaaatga 3664981 tgccttgtca gctttctgct ttttgacaat gctgttcatg attttaatgc tttcagcact 3665041 gtattgtgta tattgttttt tcagctgatc cagctgctgt cttgtcttct tcgcgttttt 3665101 cggtgtgact tggttgatga gtttgatcat actgtctgcg gtctcaaaaa aaccggctct 3665161 attttctgtc agctgctgaa tttcgatgcg gctcatatct tgattacgcg ttttttgaag 3665221 caaggcaacc gcctcgctgt tttgtttttt gagcgatttg ttctcaagct taatcgattc 3665281 gagattctcc ttcgcaatgt ctgcttcttc ttcagtcatg ctgattcgca cgaagtattc 3665341 tggattgccg attccataat caaatgcttc gctcacttgt atcatggaac tgaacacaat 3665401 ggccagctgc ctgtcgcttg cgagggcttg gaaatcctgc tttttcttac tgctcatcgg 3665461 tttggctgcg gtttgtttta ctgtcttttg atcacagtct gcgaacatct gagcctcacc 3665521 ttcactttcg catgcgctca tcacaagaac tgtgaccagc aggcttatac acaagcctat 3665581 tcgcctcatg ctctgtctcc tctctgctga atcccttctg gaaaatacca taaaatatag 3665641 ttaaatggta ccagatgcac ctaaccccag caataaatca aaagtatgat ttgaagcgaa 3665701 aaaacataaa tattttgtaa aaattgacgt gcattccatt cttttcaggc ccatttctcg 3665761 tacaatagaa gtatcgttac cggagagggg ctctgatgat gaaacgtttt acgaaacaag 3665821 aaaacagctg ggtgttatat gactgggcaa attcagctta ctcaattgtc gtgaccaccg 3665881 cggtatttcc gttattttat aaatcagcag ctgcggaaag cggtgtcagc gccgctcaat 3665941 cgactgccta tctgggctat accattgcga tttcaacgtt tattcttgcg atgctcggcc 3666001 ctattttagg cacaatcgcc gactatgaag ggtgcaagaa aaagttcttc ggtttctttg 3666061 tgtcagccgg tgtcgccagc accgcgatgc tcgcctttat ccctagtgaa cattggctgc 3666121 tattgttgct gttttatacg gtatcggcta tcggtttttc cggcgccaat gtgttttatg 3666181 atgcctttct cgtggacgtc acgcctgaga agcggatgaa tctcgtctcg gcacggggtt 3666241 ttggcttagg atacattgga agcacgattc catttatcat cagtattgct gtcatcctgc 3666301 tcgcacaagc agagactatt ccagtgtctg tatcggccgc aagccagctg tccttcttca 3666361 taacggctgc ctggtggggg ctgttcacca tcccaatgat taaacatgtc catcaacgct 3666421 attacatcaa aaaagaacct catattgtca tcaacagctt taagcggctc ggccaaacga 3666481 tgaaacggat caggcaatac cgggcacttt tcctcttctt gctcgcttat ttcttttata 3666541 tcgacggagt cggcacgatt attacgatgt cgacatccta tggatcagat ttagggatcg 3666601 gctcctcaag ccttctgatc atcctatttg tcacccaggt agtcgccgcg ccgttttcga 3666661 ttatatacgg aaaactggca gaacgcttca cggggaagac catgctgtac gtcgggatcg 3666721 tcatttatat gatcgtctgc gtgtatgcct attttatgga gacaacgctt gatttctgga 3666781 tactggctat gcttgtcgcc acctcgcaag gcggtattca agccctaagc cgttcctatt 3666841 tcgccaagct tgtgccaaag cgccacgcca atgaattctt tggcttctac aacatttttg 3666901 gaaaattcgc ctcaattatg gggccgctgc tcattgccgt taccgcccag ctgaccggta 3666961 aatcctcgac tgcggtgttc agcctgatca ttttgtttgt gattggtatt gtgattcttg 3667021 cctttgttcc cgaggaaacc agcacagatg tcagccagca gcaaaatgac ctgccccttt 3667081 aactgggagc aggtcattca tcatttattc gctttattca ccttcagctg tttccctttg 3667141 acggttgtgt tcttcatcac tttgagaaca tgagggcctt taccatttaa aatctcaacg 3667201 tatgaggcgt tatccatgat cgtgatgatg ccgatgtcgt cagctgacac accgtcaatt 3667261 ttggcaatcg ttcctacaaa atcaacggct ctgattttct ttttctttcc gccgttaaaa 3667321 tacagcttca taatgtcttt attcagctct tcgcttttgt cctttttgct ttccggacgg 3667381 tcattcagtt tagctagaaa ttctggtttc ttccttgcca cttcctcttg agaaggtgct 3667441 tctatttttt ggatttcaaa tccgatatat tcttcaatgt cggctaaaaa ccgtttttcg 3667501 aaggccgtga caaacgaaat ggcctttcct ttgttccctg cgcgtcccgt tcggcccgtg 3667561 cggtggacat agctttcttt ttcaagcggc agatcatagt tgatgacaag ggagatattt 3667621 tcaatatcaa tcccgcgcgc ggcgacatcc gtcgccacta agtaacggta ctcgccacgt 3667681 ttaaattcat tcatgacgtc gaatcggtct tcctgaatca ttccgccgtg aattttatcg 3667741 catggatatc ccaagtcatc caattcatcg gtcagctgat tgacgtgctc cttcgttcgg 3667801 cagaaaatga tgcagctgtc gggattctcc gtcatcagca catctttcag caatgaaaac 3667861 ttattctctt ctcttacttg aatcaccgca tgttcaatat ttcttgtggt taggccggcc 3667921 gctttgacct cgatatgctc ggggttttgc atatattgac ggctcagctt ctcgatatcc 3667981 tgcggaagcg tcgctgaaaa cagcatcgtc gtacgctcag tcggcagatg cttgataatc 3668041 gcctccacct gctcaatgaa gcccatattc agcatctcat ccgcttcatc aatgaccaaa 3668101 taagagagac gatccaacgg cagcgtgcct ttttcgatat gatccagaac acgtcccggc 3668161 gtgccgacaa caatgtggct tttttgctta agctcagctt tttgtttatc aaaggaggat 3668221 tttccaaata cggctgtcgc tttgatccgt ttaaatcgtc cgatgttcgt gatatcttcc 3668281 tttacttgca ccgcaagctc acgggtcggt gttaaaataa gcgcctgcgg cttgttttca 3668341 tcccaattcg ccagctcaca gagaggaatc ccgaacgaag ccgttttccc gcttcctgtc 3668401 tgtgatttga cgacaagatc ctttcgttca agggcagcgg ggatcacact ctgctgcacc 3668461 ttggtcggtt ctgtatatcc cagtccttcc aatgctcgta aaatgtcatg actgatttga 3668521 tagtttttaa aatgactcat gtataaactc ctgtctcttg cagatgttct cattatactc 3668581 taattgacca aggcatatgt gttttgtcga aaaatgatgt attaaaagcc agcgattccc 3668641 tggcgtttta gctcctgaac agccaatcgc gccagtgcgt cggcccccgc gcgattcggg 3668701 tgcagcgtat ctccatccat ataaagcccg agtgttcttt ccggaccgat cgatgtaaag 3668761 tatgccgagc tgaggacatt taagtcaatg agatatgttt tttcctcttc ggccaaagct 3668821 aaaatagagg ccctgtacca tctgtttaca gacgaatgga tgccttcaga agtaaaatcg 3668881 gttgcccggc cctgaggcgt tgataggatg acgtccgctc ctttcgcttt tacctgacga 3668941 atcatatcac gcatcacctc tttaaactcc gcttcagatt ctttatgctt cggatttgtg 3669001 tcattaatgc caagctgcaa cataaaataa tctccgggtt taatatactt cagaatcgcc 3669061 tcaagctgtc catcatttct gaaccctctc gcgatctgcc cgccagacgc catgtttctc 3669121 acttgaaagg tgtgtttatc gatatagtga ggcagcatct gcccccagcc cgcctgcttg 3669181 ctgctgttga gcggataata attgcacacc gtcgagtcgc cgccgacata aatggttcga 3669241 ttcgttaccg gctgatcaga caatttcttt attttcaagg cgctgagcgt aaaagcggtg 3669301 cctgcctttc cctctgtcac cagcagattc agctgcccgt cggtgacggg aatttggaac 3669361 gtatcctccg cgccatcccc tgtcatattg atgacctgaa acacgccctc cgctgccaca 3669421 ctggcccttg ccgtattgcc aagcgtcacc ttcacctcat aaaggccatt cgggagatca 3669481 acattaaacg tgttattgct tttcgtccca tacgctaaaa actgaaccgc atcactcttc 3669541 acaccagccc cggatgccgc cacatccctc atattctccg gtgtttgaaa accgtagccc 3669601 tttgaccggt cataccgatc agacgccctg acaccaatat aaccaggctc catcgaaccg 3669661 cttccaaagt caaactgata caccttcggc tccgccgcct tcacattctc aatcccgcca 3669721 aaacacagca tcagcatcat cacaaaaacc gctgccatcc attttttcat caagactccc 3669781 cctctatgaa aacgaataca ttaatgcata ctcggtgatt gtttctttat gatgactgaa 3669841 ttaagaaaaa aattgcgttg aggaataaaa atgaggggag agtctcaaga aggggaaaat 3669901 cagtgtgact tcttgtcaca cttgatcaca tcccaacctc cgcaatagaa gcttatttgg 3669961 ttttcttcgt catacacata ataacggagt ctttcccatt gatcgtcagt cggtacaatc 3670021 tccaatgcaa ccgaatcgat ggattcaagg tcatccagct ttgatgcact aatgttttca 3670081 aaccgcaatt gaatgtcaca ggtttgagca gatcgttttc attcaaacac aggaatatga 3670141 atataacgat catcttcttt catatagaaa gaaaactcgt ttaatgtaaa tggacctgta 3670201 tcctcatcag aaagatgctg tttcaatttc tcgtattgtg tgatattcaa atgaattccc 3670261 tctatttata tgattcaccg ccaatcatat aaatgtccac agcatcgtat tcaaaccata 3670321 tgatccgttc gcctgagtcc gttaggcatt ggagcttccc ttctgaaaaa tagcttttat 3670381 ccggttgagg atcagtgatc agaaaaacat catcattgat ggaagctagc agaaagagaa 3670441 aatctgcaat atcccggtct gcttcctgta atatggattg gaaatggaat tcccttttgg 3670501 ccagcttcgt caccttgtaa gcatgacctt caaaatactc ggacaggtct tctataaatg 3670561 aaccagtcgt tattacctgt atcatgattc gatcgtaggc aagccctgcc caaaaacgat 3670621 aaaacgactc tgcatcttca agttcgcatg ccataacggt ttggtcaggc ttaagctcga 3670681 tcatgtccaa attgccaata ctgcttatag aggttatttc cataaaatct tccccttatc 3670741 agttggatag cgcaacgcaa atctcttgtc tgacttgttc atacaagaga atgtgatgat 3670801 acagatcctt atcgtttttg atcatatccg gaagtatgtc aggatacagc tcaaaaaagc 3670861 ttttctccaa cgaacgccgc tgatgccggg gtatcctttt attcgccagc acataatcca 3670921 aactgccagc aacaagcata aaaaactcat agatttccgc ttcaaagccg tacaattcat 3670981 cagggtactg cttttcttca agctctcgct gtctttttct cagtttttga agcacgttga 3671041 tcctctccct tccgcaataa tctcatttat ttcgaaacag aataggcgga tcattatcta 3671101 tcgcctccaa cagctcttca ccaaacacag tgattgcaca tttccacggg tctcccaaaa 3671161 gtccccagga gaagtcctga tgaaaaaaga aataatagtc tccatttgga aatacgggaa 3671221 caggccattc gccaaattca tccttaggca ttgcctgatg aggactaaag gtatatccgt 3671281 catgctgcca atctagtgcg tacattacat cgttctttcc agtacctaat tgaaatgctt 3671341 ttaaaataga agtctctaaa tcacttagca ctccgctcac atcattatga ccagctttac 3671401 tgctcatcgc gcttgagata tcaaacactc gatatggatc aggcgggatg atgtgatgac 3671461 atctgcttcc gggcttccat tttatgatct tgttcacttc tgaccagatg cggtcttgtt 3671521 ttgtctgact taaagcgcgc caattcatca taatctcatc cctacacctt attggatatc 3671581 ctgcttataa acaccagaag aggccactgc gtaaacagcg taacttgtca gtttcagctg 3671641 ttgaacatct aggccttcac cgttcgaatc acagcatgtt atctcttcca tctcttgact 3671701 cacatcggca gaaatcaaat aaagagacga cttaaggtct gcactgtaac aattgaacgt 3671761 cccaaccaaa aaaccttctt cggatatcgc gagctgatca aatgcttctg agtccggctc 3671821 tttatccgac agaatccaca cccgtctcac gaccgtttca tcaaatgcgg caatgactgc 3671881 atctccgtaa tacagcatat aaatcaagcc gtttttttct gcaagtccat aacaatcatc 3671941 tacagcaggc gcatccattt cttcaagctt tctatcaatg tgtatttcct tctgctgacc 3672001 atctaacgta aaacaccaca cactatggcc gttgggattc tcatcatgat aaatcccttc 3672061 atcacataaa ccgacccaaa gctgttgttt ctaatccaaa agacagcagg aaacccctga 3672121 aggcaagtga aaaacacttt tcacccttcc ctcttctgaa aaaaccttta ccttcggctc 3672181 gtacgattcg taataaacga agacatagcc atctgcacat tgttgaaaga gcagaatatc 3672241 actgtatgaa atctgctctt tcactctaaa atcccgaaca tcaccggaag gatcatagat 3672301 tgtaatggtg ataccacctt tcaacccttt tccaatgtag acacgcccct gtggatcagc 3672361 atggaaaaaa caatcttggg tgttctcgtt gatgatttta ttcaatttta attttttcat 3672421 tggttatgct cctaggttcg aaatgaaatg ataagaataa accatttatt agctattagt 3672481 aacggacaac ctagtttcat taatcgtttt gggataaatc tactttccaa ttcagcctta 3672541 aatcatttag tgtttaattg gtatgcataa aacgattgat catcaaagcg aactgtttca 3672601 gcttctatag caatcagcat tctgttcatg tcaataagaa agttagcatt tgattgatac 3672661 tccggaatta tagaatttga tagattcccg attccttctg gatgataact catctcaaat 3672721 acttgccaat tgtattcttc cggatctatt ttttccaatc tcatgtcgcc aacatctgca 3672781 ctataataag cggatgccac attttgaaat gaaattttat gcgtatattc accttcatct 3672841 tcaaaaacct taatatcaag tgagagttct tttttaaaca cattaaaatc taaatgaagg 3672901 acactgcacc ccttatctat ataatcaacc cattcattaa tcgtttgata cattgtcatc 3672961 ccctgcctct ttttaaacaa taacgccttg ccaccaagca gaaaacaaat tactccgtat 3673021 attgtttgat ccaatcattt aaatcatctg ttgaatgcaa ataagtttct gatgaatctt 3673081 tcaaatcaat cccacttaga aggattaaca tatcccagac tctatcgtct tctacttcgg 3673141 ggtcatccgc ataaacataa gttccagccc aatccgacac ttcttctctt gttgtttgtc 3673201 catttaagac acttttgatt ttatttatgc attctattag atttgtctcg ctcaatttga 3673261 tcaccacgta ttcaagtact aaatgatttt ttattagtat gcaaagcacc gtactgatat 3673321 ttagatattg aagctttttc cgtaaaagat atgttccaaa aggtttccaa tctaccaata 3673381 aacaagctca catccgtatt ccgtgtgcaa tatacataaa ccaaactggc acttaggctc 3673441 aaccaaaata aaactatgat tgagaatccc ttcatcgaac tcaatacact ccaataagca 3673501 gtcaaggtgc tcgagacatt ttccaaaaga acaaactaac gcaccaattt cgctgctgta 3673561 ttgatgaaac agcagaacgt cccggtcatc gtaagcaaca tatgactgag atattttcca 3673621 gatcagctgt ttcgcttccg ttttttcgag ggcatcaacc tcacgggtgt tggctggtat 3673681 tgaatttgat aaaaccagct caagcaattg cctgctttgc gccagatcag caaaacgata 3673741 agtgaagcct ctttctgcac aagggactag tttttctttg atttcgctca tcaataaacg 3673801 tcttttattc tcggcgagtt tttcgatcaa tcttttttgc atgagccgca ttccctccgc 3673861 tgtcaatttc tcaacttctt ttaaattgat tcatcattct cttgttttcg ttgtcgttca 3673921 tgtttagatt tgttctaaaa aagcttgtat cgcttatcga tacaagcttt atcttcaact 3673981 gcttaaaact cacccagtgg gcttttcaca aaacgctggg aacctttttg gcaaatcctc 3674041 ttcatcccaa tcaattctat atttttagat tcttttgtca tacaaataag agaggatggt 3674101 aacatctctt atttaatgtt ccatcaataa atgccccatt tttatccaat gcagaaatta 3674161 tttataatta aggaagttta gaaggatttt ttgtattttc aagatttaat tttaaagcgg 3674221 tcacaaaaga ctctagcttt tcttcattac aattaatttc gaacaagttg gagttcgact 3674281 tactttcttt ataatcatca aatataattt taatcttaat tctgtaattt ccgttttctt 3674341 gatcaatact aagaaataag aatggttcaa tagtctctaa actgatactg tcttgatttc 3674401 cttttatcat agtttcgatc ccagatatca acaccttata ttcactttct aataaaacag 3674461 cagaaaaatc gcgaacgacg gctttcttat tttccaacaa ttcaaataca gataaaataa 3674521 atggatcatc gtccaactct tgataccttc tcggtgttaa ttcaagttct atacaatcat 3674581 cttttatttt ggccatattt cctcctcatt taaagtttaa gtgagggtag ttgtcatccc 3674641 cccctcgctt aaccttatta acgccttctc ttagatttat ttccttttcc gtgtgtatgg 3674701 aatacgtgtt tagaaccctt agctcttgaa cttccataag ctgtgattac tttacccctt 3674761 ttatttaaaa caactgtagc tttttttcca acatatttcg ttgccccatt aggttgtttt 3674821 attacttttt tagggcttcg cacagcattc agtttggccc ttaaattgac tccacggcct 3674881 ccatttcttc ctatagattg attaagtcca tgtcttgtat gacctgtgat tttaactgcc 3674941 ttcttcgtaa acttataggc gcgactagca cccttaaata tcttcccagg accaaaatta 3675001 gaagcagctg cccaagcagc acctttccat cctttacctg atttatatgc cttatatcca 3675061 tcataggctg caaatccggc atttaccaca agccataccc aatgcccgtc cggatcaaca 3675121 ttcatcactg ggttattatt tccataagca tacccattct gatccaatga atctccgtcg 3675181 ctgcccgggt ctgggtcgag cgataggaac acgccgtttc ttggctcgta gtagcgggcc 3675241 atgagatagt acaggccggt ttcttcgtcg tattggtagc ctgcgtagcg gtagcgattg 3675301 tcttttactt cgtcgcttgc ttcggttttt gttggatttc cccatgcgtc gtattgatac 3675361 ttggcaacgg tttttccagt gctgtctgag atcgcgatga tgtcgccgtg agcgttgtag 3675421 tgatagaaat atttcttacc attttctgtg taggataaca gctggccgct gtctccgtac 3675481 gtgtatgatt ttgtgacgtt gttgtccgcg tctgtttcat acaagacgtt caagctgtct 3675541 ccgtcgtaga agtagttcgt gacttttccg ttgacggttt tttggattct gtttcctttt 3675601 tcgtcatact tatatgttgc gaatggcttg tcttcgcctt ttttggtaac ggcggtcagg 3675661 ttatcttctg catcccacgt atatgtgaat ttgccgtcgg atgtgcggtt gccgttttta 3675721 tcgtaagaga tgctttcatc attgactttt gtcagctggt tcatgatgtt gaaggaagcg 3675781 ttcaccgttt tgcttgagcc gtcttttata gttgtaacgg ttttccggtt tccgaatcca 3675841 tcatatgtgt attcaataac agtaccgtct tcatgggttt ctttgacaag ctgattcagc 3675901 ttcccatact catattgcac cttgccgctt gctgagctgt ttatcgttgt gcggttgccg 3675961 ttggcatcat attcatagct ttccgtcaga atgtctccgc cgtttttgtc accgatatgc 3676021 agcgagctta caaggtttct ttcgtcatat gaaaaacttg ttccgccgcc gttgcccgta 3676081 ataaaggttt ggacgtttcc attttcatca taatcaaatg aatatgagga tgtactgtct 3676141 ttcatctcaa tcatttgatc cagcttgtta tacgtaaatt gattcgttcc tttttggtcc 3676201 ccatgaatcc acgagaaggt tttcagctta tcggagtcac taggatatgt ccaagtttgg 3676261 ctgccgccgc ggtctgtcag ttcggttaaa cggtttttgt tgtcaaatgt ccgtttcttt 3676321 gtggtgttct gctctttatt gacgaccgac gtttcatttc catttttgtc atacgtgaaa 3676381 atgtactttt ctgtaccgtt atacgacttt gatttcaccc ggtctgttcc atcataagaa 3676441 agagacactt cgttgccatt tggtgaaatg gttttggtca ggttgctgtt ggcatcatat 3676501 tcgcttgcta acacattgcc gagagggtca gttgttttga caagcttgcc catgacatca 3676561 tattcgaatt tataggtttg atctgctcct gcccggatgg ttttgcttac ctcattgcct 3676621 tccttatcat agctgtgaag gatagacgtg ccgttagaga gcgtcatgtt tgtcaattgg 3676681 tctgcctgat catacgtata ggttgttttt tcaccttttg catctgtttc agacgttttc 3676741 ttaccagttt catcgtaatc agttgaagtg gcgtaaccta gttcgtcctc ttccttggtc 3676801 acatagttgc cattactgtc atacgtgctt ttagtcagaa ggcttccttc aatcaaacgg 3676861 atatcatcaa accagactgt gcctgtcgca ctcttttgga acagaatact gatatcgact 3676921 ttattgatcg gctttgtttt agggatgacg acagctgctc ggttccattc ctgtgttcca 3676981 gaagggaatt tcgcattgta gatgcctgtg ctgccgtcag cgtaagtgac attcgcctgc 3677041 agagaatagt ctttttcatc tgtaaatttg acgctgcttg ctttcgacat tcctgtcagt 3677101 gtgagataaa ccggtttgtc atttgcgctt tgccctaaga caacggtttg ttttgttact 3677161 gatccggctt gggacgcact ggtccgggca gcttttaatg atacatcatc attaaagcct 3677221 tcttcagaat caacggatgc tccgcttaca ttccagtttt ccgttgctga tgtgaagctg 3677281 ctgttttgaa ctgggttata gcttgatgat acttcgcctt tttccagctg gacttcatca 3677341 aaccatgctt ttcctttgcc atctttatct ttatgatcga cttccatata cacaacagct 3677401 ttgcctgcat tcgctggagt cgtaaaagtg atttgccgtt ttgtccagtc attttttccg 3677461 gctaatgcac tgtattcatt gtgaatccat tgaattcgtt tttgatcttt gtctcgcaaa 3677521 tcaatgttaa aataggctct tgatttcgca agatctgttt tgattttccc gcttaatgta 3677581 taggttgtat tcggctccag ctcaactgtt tgtgttgctg acgaataccc atgatctgtt 3677641 ccggcagacg ttgattggct caagacctcc aatgcctttg atccggaaag aactccgctt 3677701 ttatcggcga tgactgaaat tttgccgctg tctttagagg cagtcagatt ccagccggat 3677761 ttttgagctt caaagcttcc atctttcaaa atattagttg aagctgataa atctttgctc 3677821 gattgaatct ggtttccata tttatcataa acagctgctg acgatgattt tccgctctga 3677881 tcggtttcgg atacagcatc cagtccgtca taagcaatat ccgtgacatt gccctcggta 3677941 tccttcatct ttgtgacatc gttgtttttg ttgtattcgt atgtctcagt tccatatgca 3678001 tctttaaccg acgtaacgtt gccatctttg tcatattgat agctttccgt tgcttttccg 3678061 gtgccgacgt catttggatc tacatcttct acaacattgt tgccttcata ctttgtattc 3678121 gttgtaattt ttaacccttc cgcatcatca atgacctgaa tcggatttcc cgcttcatta 3678181 tagccatact gtactttccg gccatttggc tgtgtcatga gaagcgtctt tttatcagca 3678241 tcatagctgt agacatatgt ttctttttta gcgttgatcg ctttttcgag acggtgaccg 3678301 ctatactgat attcggtaaa gacaggcttt gcttcggtac tgttagctga atattgtttg 3678361 acaaggcgcc cttcactatc gtagtcatag cttgtgacag tcccgtctgt atctgtaacc 3678421 ttcttcagca aatcattctc atatgagtag gtgactttct tattcttagg tcctgtgatg 3678481 gacgtcacat ggccgttttc atcataggta aatgtaagct tgcggcctga tgcatctgta 3678541 atggcggtca gttgattttt gtcattgtaa gtatagacag ttgcattgtt atggccatcc 3678601 actacctttt ggagtttgcc gcctttttta ttgaaataag cgttggtttg atcctttgtt 3678661 tttaatatga actgatcagc tgtttctgtt aattcaagat atacaccggt cggcggctga 3678721 tacgtgccat cggctttttt cgtgaatcga tgtgtcgtag cgtcttcatc gatatacatt 3678781 gccccgccat ccgttgagat gacagatgtt tctgcatcag cataccagcc ttgtccaaat 3678841 aagtgatcag agctgtcaag actgttgtag gttctcgata agccaagtcc cggaccgcgt 3678901 ccatcaattg acaaatcttc ttcattcaca atgacattgc ctgtcgcacc atttaactgg 3678961 ccgcttggga tatcaatgat agaccagtac tcttctgtac ctaggaattc tgcgccttca 3679021 tggaacgttg ggttaaaggg cgccgttgga atcgtttcac cattcgcatc ataggcgaca 3679081 agcgtgaaag aataattctt cttccctttg taattcccat ttgcattgtt atagacaggt 3679141 gatggatcga gggctaattc cccgcctttt ccatctgtat gaagcttata gcttccggct 3679201 ttgatttcct cagaagtcgg ccagatgttt ttattttggg ttgtccaatg atcagcatca 3679261 ccaacatcaa aggactgata ttctttaccg ttgtaaatgt taactttata gcccttcgca 3679321 ttttgaacct tttcccatat caaattcaca taacccgttt gactcgattt tgtatttgta 3679381 tacaaatagc cagttacatt ctttggccta gcgatatcag gaagtgccgg ggtagcagcc 3679441 ggggatgcaa tggcttcgcc gtctttgttg tatgcgataa ttttaaacga gtaatttctt 3679501 ttggctccat ctcccccggc gtttttatag gttggtccgg gattgatcgg cagctctgct 3679561 ccgcttccgt cctttaggtg aagagcatat tttcccgcct tgatttctgc acttgtcggc 3679621 cagatctttt tcccttttgt ggtccaagac gtctgatttc cgagatcaag tgtctcaaag 3679681 cctttcccat tgaacacctg aaccttatag ccggttgcac cggatacagc tttccaagaa 3679741 aggtcgaagt atcctgtggc attcccatta ttgtagccct ttgctgacgg tgcttgtgct 3679801 tttcctacat tagggataac gggctttgcc ggtgcggaca tcgctccttc accttggtca 3679861 aatatcgcac tgacgccaat ccaatagttt ttgcttgtag catagcttcc gccggaattc 3679921 ttatagaccg gggatggatc taatgccaat tcagctccat ccttgccgtc cagatgcagt 3679981 ttatatctct tggaggcaat ttctgcgctc gtaggccaga tttttttacc ttttgtgctc 3680041 cacgacgtga cgttgcctgc agaaatcgct tgatattcct taccattgta aatccatacc 3680101 ttatatcctt ttgcgccttc aacctttttc cagctgatat cgaaataacc agtggaatcg 3680161 ccgttgtgat aggctttgat tgtaggtgtg tttccctttg gaatggtata cgtcacttca 3680221 atatatggtt tattggcgga gttcgctgaa gaaattagtt ttttccaata ttccttgccg 3680281 tttccgtttg tatgaagctt aaatccatag ttggccccgc cggagttcca tgactttaca 3680341 gcagcggtca catcataact cgcccactgt cctttatgga cgtcggcttt tccgatattt 3680401 ttagatgccg gtttggtgtt ccatgtcact tttgcattat cataattgct gttgaccgta 3680461 tccagccaaa ggccggttgc ctttgttcca taataggaat gggctacgta tgtttttaat 3680521 gtagctttag tgacagtcat attttgaatt ggctttaggt tgttaaattt catgaacgca 3680581 tagtttgtgc ctgttgtttt gtcataatag cccgttttca gtacataggc ctttaaatta 3680641 gcatcccatt tttgtgagga ggccgaatag ttcgtcgtcg ggtaggcact catgacaaac 3680701 gtatccgatg aaacagataa agaagttgac gggtcgatag atactggata tacgcgttct 3680761 gggtctttca gccagttctc gtctgccgta agatgaagca aatacccttc ttcattcttt 3680821 tccagcttat agctgacttt gtctgaccgt tcaacctcgc cggaaagctc atctagtttt 3680881 gaatccgtca taaaaggctt aggcacagaa aaaacaactt ttcctttttc atcagaaaaa 3680941 tcaatggatc catcctcttg ttctttagcc tgcaaatcgg tttttaactg aaatgtaaat 3681001 gtgttgtatc cattatactg atgaaggact aaatcttctt ttatgttttc attgaatgtg 3681061 aaagtctgaa gatcaatatt cggaaacaca tccggataca caatctcatt actgtcagtc 3681121 ttataatctg ctgaggtatc tttcggagta agtgaagttt tattcgggcc tttcgcttct 3681181 gctagtgaat atgtaacctt atggtcatta tgctcaaaag tcgcataaag cccgttcttc 3681241 atttgctttt gaaaatctga attcaaaata gcgttctctg tctcgacttg tttgcttgtc 3681301 gactctttta actcaggaga aatgtcttcc cagtcggcat ccggtgtttc ctttgtatga 3681361 ataggatcaa ggtatacttc ctgtttatag acaccgtcac cttcataata gagttttgta 3681421 ttttctgttc tttcagaggt gatctcaccc tctttgttta tatcttttgg atcaaaaggt 3681481 acagcttcct cagtttgttc tttctgaaga gtttcttctg gatcatcggc agcaatacgg 3681541 tttccattct cttcttctgt agattttgct agtacatcgg ctggcactaa tgaaatcatt 3681601 aaagccaaca ctaaaaatgc tgcaatgaac cttttaaagt ttcgcctctt tctttttttc 3681661 atttcctctc tccttttgta ataaaagtaa tatttactca ataatcttaa ctagactgaa 3681721 atatcattac aatatttttc tagaaaattt atcttatttt aaggattagc gagagtcaat 3681781 tgacctaaaa caaaaaaagg ccgcataggc ctttttacat tttttattgt atttgttcaa 3681841 tatccgtacc ctcagctgtc acattcgcct tcccctgcct cctgacaagc gtcaaggcca 3681901 tgcccgcaaa gatcattacg atgccaagcg tttgatagag gtcagggcgg aagcctgtga 3681961 agacggtatc gagcacgatc gcgacagcgg ggtcgagaaa tacaatgatt gaaataaatt 3682021 tcgttgataa aaatcgtaaa ctgtcaaaaa acagcaaata tacaataccc gtatggatga 3682081 tgccggtaga taccaccata atccagtttc cctgagatag gtccgcaaaa gcgccaaagt 3682141 gaataaacgg aatcaggatg ataaccccta aacctgtctg caagaaggtg gtcgtgtaag 3682201 gactgagatt gtgaatgcct tttcccaata aagtggtgaa cgcataaaac agtgcggcga 3682261 gaactgccca tatgatccct gatcccatca gctgtgtcaa tgatgtgctg ccgttaatcc 3682321 cggaaatcag cgcagtccca agaaagcaga tgataatgga gctgacggag atcacattta 3682381 atttctctct gtagaagaag ctccccagaa gaagaacaag caccggcgct agatgataaa 3682441 cagagatggc aattgtaacg gacgtttctt caaaagactt aaataagaac acccagttga 3682501 atacaagaaa gaaaccgcac gccaatgttt gcagcacgtc tctcttgctc catttttcag 3682561 ttttatactg gccggacgcc agccagcaaa agcctaaaaa cagcgtcgcg caaaggcagc 3682621 ggacaaagac caattcaaat gacggcagat tggtatgctc tgagaaaaag ccgatggagc 3682681 cgaaaatcac catagagatg accattttga ttacggctgt tgatttttgt tttgacgata 3682741 tggaaggatc ctgttgcatc aaacgtattc tacctccaat actgcatagc ataaactgtt 3682801 ttttgtgaat tcagaaatct acacatagaa ttcctctttt ttacatgtag atattataac 3682861 acttctattc taaataaaaa aaagcgccca agggcgcttt ttttacaaat ctatcgaaca 3682921 atcaaaaccg ggcatgttga taattgagac actttatggc tgacgcttcc aagcatcatt 3682981 tctttcaggc cgctgatccc ccggctgcca actacaatca ggctgacgcc tttctctttt 3683041 gcgtgattta gtatctcatg cgccggctcg ccattcgcgt aaatggtttc agcttgaacg 3683101 cctttttcgg ctgctttttc ttttgcattc tcaaggattt tcaggccctc ttttttaacc 3683161 tcgttcctga tttcatcaat aaagtgttca ggcacataga caattcccgt cagagaagaa 3683221 gtcgtgacga cggcttctct ccccacatga agaatgctta gttccgcttg ttgctctttt 3683281 gccaaatgca ctgcggcatc aagcgctttt gcactcatgt ctgatccgtc aatcgctact 3683341 aacattttgt taaacatgct cttcccgcct ttcggactgt gggtggttca tctttctctt 3683401 ttattgtccg cctgcatttc gttattgtca attgaagcgc atgagttttc aaaaaattgt 3683461 cagagactct ctccgtttgt ggcgataacc tgctgatacc agttgaagct ttttttcttg 3683521 atgcggttaa atgttccatt tccttcattg tcccggtcta cataaatgaa gccgtagcgc 3683581 tttttcattt ccgcagtaga tgcgctgaca aggtcaattg gcccccatga tgtgtatccg 3683641 attaattcaa cgccgtccgc aatggcttcg cgcgcttcaa ttaaatgatc acgcagatag 3683701 ttgattctgt aatcgtcctg aatcgtgccg tcctcttcaa ccttgtctac agcgccaagg 3683761 ccgttttcaa cgatgaacag cggcttctgg taacggtcgt ataaggtgtt gagcgtgatg 3683821 cgcaagcctt tcggatcaat ctgccagccc cattctgatg atttgaggta agggtttttg 3683881 actccgccca gcaggttgcc ccctgatttt gcaagctctt ccggatctgt gctcgccgcc 3683941 atcgacatgt agtagctaaa tccaatataa tccaccgtat gttctttcaa gagctcttca 3684001 tcgccttcag ccatttcaat ttcaatattg ttttctgcca gatagcgttt catatatccc 3684061 gggtatgcgc ctcttgcctg aacatctgag aagaaaagtg ttttgcgctc attctccatt 3684121 gccgcgaaga catcctccgg cttagaagtc atcggatagg ttgtcgttgc cgctatcata 3684181 cagccgattt tcgaatcagg aatgatgtcg tgacccgctt tgacagcaag agcactggcc 3684241 acaaattggt ggtgtgccgc ctggtacatc gcgtttaatt tgttttctcc ttcttcaaaa 3684301 acaagaccgc ctccggtaaa tggcgcatgg agcactacgt taatttcatt aaacgtcatc 3684361 caatacttca ctttgtgttg atagcgtttg aaaaccgttt tggcatagcg ttcataaaac 3684421 tctatgactt tgcgattctt ccagccgcca taatttttca ctaaaccgag cggcatctca 3684481 taatgagaga tggttacgac aggctcaata tgatgcttta acagctcatc aaacagatca 3684541 tcataaaatc tgaggccttc ttcattgggc tcctcttcat cgccattcgg aaaaattctc 3684601 gtccacgcaa tcgatgtgcg gaacgcctta aatcccattt ctgcaaataa ggcgatatcc 3684661 tctttataac gatgataaaa gtcaatcccg ttgtgataca gattcaagga agtcattgat 3684721 tcatcaaatg gagacatgat cccgttcggc gatacgtcag ctgtcgaaag ccccttacca 3684781 ccctcgttat aagcaccctc cacttggttg gcagcaactg cgccgcccca taaaaatcct 3684841 tctggaaatc gtttttcatt tgaactcata ttgatcaccc cattagtttt ttcaagataa 3684901 agcaagcagc gcttcttttg gctgcacttt accgatctct ttcaccggcg aaaacgaata 3684961 ttggtctgtg ttggtcacaa tcaccggggt aatgacgtca tatcccgcgg ctttgatttg 3685021 ctccagatca aaggacacga gcggatctcc cggtgcgacc ttgtcgcctt ctttgatgtg 3685081 agccgtgaac cattgtccct ccagctttac cgtgtccaat ccaatgtgta tgagtatttc 3685141 agctccctga tcactcgtaa tgccaattgc gtgttttgtt ttaaaaatgg tggtaacgct 3685201 tccacgaaca ggcgaaacaa cttctccttc ttcaggctca atggcaaatc cttttcccat 3685261 gaccccagca gaaaacactc cgtctttgac ttcacttaag gctttcactt ctcccttaat 3685321 cgggctgtga atgatctctc tgctgccttc atgcactgcc ggctgctggc tgccgtcaga 3685381 aggcacatcc tcgaatccaa gcaaatacgc agctgctgtt cccgccgcaa acgcaatcac 3685441 aaggccgatc atcgcgtaaa taaacgttgg gccgataaag acagggatgc tcggcagacc 3685501 tgcattcccc ccgacgatat aggaagcaac acccgtcatg ccgtaaaacg cgccaccggc 3685561 tgcaccgcca atcaaagcgg ccgcaaacgg ctttttcaat cgcatattca cgccgtacat 3685621 cgcaggttct gtgatcccca tcagcgccgt gatgcttgtg gtaagcgcga gtgatttaaa 3685681 ttttttgttt ctagagcgaa ggaagacggc aaatgatgct cccgcctgcc ccatattcgc 3685741 caaaaacata gccggcagta aataatcgtg gccgttttga gcgatgttgt tgatcatgat 3685801 cggcacaaag gcatagtgca tgcccgtcat aatgattaaa gagaatgtac ccgccagcaa 3685861 aatcattgcc acaagccctg catgatcaaa caaataattg accccagaag acaagtattc 3685921 tcctaaaata gcgccaagcg gaccgactgt aatcaatgtc agcggcacga caatcaatag 3685981 cgtgaatgtc ggaaccacaa tcaatttgag agatgcgtgt gtaaaacggt caatccattt 3686041 ttccacgtat gaagcaatcc aaatcgacag caaaatcggg atgaccgttg acgaataagt 3686101 ggcagcggtt acaggaagcc cgataaagga aatcggtttc cccgcaccga gcagggctgt 3686161 caaatccgga tgcaggatcg ccgccgcaat ggcagccgct acgtacggat tgcttccgaa 3686221 ttttctcgcc gcactcatcg ctagcaggag cggcaggaag tagaacgcac cgtcaccgac 3686281 agccgtcaaa atgacatgaa cctggctctt ctccgccatc cagccaaacg tgactgccag 3686341 cgccacaagt cctttgatca tccccgctcc cgcaatcgca ggcagaatag gggtaaacac 3686401 cccagaaatc acatcaaaga ccgcactcag cacattcttt ttctgagagg atgaaccagc 3686461 gctcttttca tcactgagat tgctgtgccg cacaatcgcc tgatacacct tcggcacatc 3686521 gtttccgata atgatttgaa actgctcgcc gctgatattg gtgcccatca ctccaggcag 3686581 ctgctccagc tgactgcgat ccgccttcgc gttgtcatga agattaaaac gcagcctcgt 3686641 catgcagtgg atcacgcgct gaacgttttc ttcaccgcct acgagttgta atatgtcctt 3686701 cgataattta tcataatcca tgtgtatacc tcctttttat ggggggactg ctggatgaaa 3686761 ggtggccgcc tttcaccagc tttttttgta tcaaatgctg catcacctcc taaaagagaa 3686821 taaaaaaacc taaatgacac agattgcgag agtctcctcc tgcacctgca ccatttaggt 3686881 tttgcctgct ttcgcagtaa caatcctgac gggtcgtttt atttgtttgt aggtatactt 3686941 tagcactaga ttcgtgagat gtcaacgctt tcatttttgg tgttgactat cgtttctaga 3687001 acaaaagtaa tcataaagat ttgaacttag tattaacttc aataaaaaat tattgtaatt 3687061 aaaaaccttg aaaggcattt tttccaatca aggttatgaa tcgttaccgt ttaaattttt 3687121 ttaaagactt ctttatctgt actattacat tctttagcca atctattggt tctaaattaa 3687181 acgcaggaag atacacgcca tctgcgcaag attgaatgta atcgtttttc ttattgtctg 3687241 aatgctcact ttcaataaaa tccgttaaaa agacaatagc atcctccaaa tattccttac 3687301 tttcctctat taataactct tgtatagcgt catcaggagt ttcaatatct tgatggaatg 3687361 ttccagctaa aaactgaaaa acagggtcct tctgtttatt gatcaataac atgtcatctt 3687421 gctcctttaa gggagaggta acgggataat gttaaaatca ttcatcatct aataaatcaa 3687481 gataatactg atcattctct tctatttttc ttaagaactc ggtaagagaa gttgcaattt 3687541 gaatatcata atagtaaatc ggatttttat tattatcatt taattcaatt gacattaatg 3687601 ccgattcact accttcaaaa aatattaatt tatcattctc aaactcatca tatatttcta 3687661 tgtcaggata aaattcaaag tcatttatcc tcaatcgaaa gtctcttaca gaatatggat 3687721 ccaaaatgcg attagtatta aactctgatc ctttaataaa cccatagcca acttctaaat 3687781 aaaaattcac taattcacta ggtaatttta agtttaaatt tttttcaacc tcttcaatct 3687841 cactttgatt cactggataa aaatcatttt ctttgtttga ttttataaaa ttataactca 3687901 tttttttttg cctcctttaa ataattcatt tgctggtgag cctgtaccat gaatcccagc 3687961 ttgatgctcg ttaggaaatt ttgctggatg catattccac cattcatgtt ctccgccaaa 3688021 agtattttca attatatggt gagcatcata cttatcccct ttttttctaa taattttacc 3688081 tgttttttca gatacaacat tttccttata aacaggccat ttttgtccag tgttttcttc 3688141 ccattctttt ataactttat tttttacttt atcaaattta gtcctgtgtt ttgcagtctc 3688201 tattggtgac atttttttat attctttatt tcttaatgct tcctttaatt tatctatttg 3688261 atttttaggt aattctctac ctgtgcgttg ttctatatct ctagcatact tttttattaa 3688321 atcagaatta attttattag cagatccact tacatcattc gcaattttcc ctttatcctt 3688381 agcaacgttt ttaacttccg aagccttctt agcctttttc ccattattaa taagtttatt 3688441 aatatctatt aacttttcta acttagctat tttggcaaat ggtactgagt ttatggaggc 3688501 aacaacacgg tctttccctg tgactttttc gcctgatacc ggatctctgc ccgtggctgc 3688561 tttaaataga tcatacacgc cggtaagttc tacagccgtc tctaaaattt tcacatatcc 3688621 attctcatcc actttaatgt ccgaaagcga gacgacaggt tcaagcttca tgtcattacc 3688681 agatatgtat acattgtaaa gtgtatcatt ataaacgact tgcttaacct ctgcatttga 3688741 gaaatcagtt tttatatgtt ctctatgttc actcgtatta tacactttac cattgataac 3688801 gatgatattt ttacttacct ttttagaatc acccgttttg acaactgaat ccactttaga 3688861 cttttcattc tcggctaatt tcttcagcat catctccatc ggtgaatcat ccgcctgctt 3688921 catttgcggg ttaatcgcgc cgaagatttg gttgatgttt tcttcttcct gtgatttcag 3688981 gatggagccg cttttgtagc ctgtgatttc aattttcggg ccggtgtaca tggtttcgag 3689041 ctgatcaatg tattttttca tcgtttgaaa atctgatttt gcggcttcta gtgcttgggt 3689101 ttgctggccg tcaaattgaa agagcttatt cagggtgtct gaaatcagcc gctcagcctg 3689161 ttctgtttcc atccgaaaaa aggaatcatt gactgtcggc aggctgacga tgtgatctat 3689221 ggctgatgtc tggcgattga ctgcgtcagt gagctgctct gtcacttctc gtgcatgctt 3689281 gaccccatgt ctcgcatcgt gtgagagaaa agcctctgcg atcatgccgt gggagttaga 3689341 ttctacagag gaaatcgcat gctgtgtttg tttcagcact tttttgtatt cgtcgataaa 3689401 tatgccaaag aaaaggagaa aaggcttgtg gcactcctcg taaaaggtcc ggatggcatc 3689461 tccgcctttt cctttcagcg catccttcat gcctgccaga tgctcaacgc ttttttccag 3689521 cttctccagc tgttgttttt gcttgtccag tttctcaatc gtatgctgaa tgccctcgtg 3689581 aagagcgtgg acatctaatg ttttcaatcc cttgtcctcc cgcgctttat ttcatggaag 3689641 atgatatgtt ttcgtccgtt tccttcatgg cgtttaccgc gctttccgtt tgtgcgatat 3689701 gcttggccag aacagacgca tatgcttcag tgagctcttt gatgtcctta tttaattgct 3689761 cgatggactt cacaacattc aaatggtttc tgcctgagag atgaccgggc aatgaggact 3689821 tgagttcagc tgaattcttg agctgagaaa gcccttgctt cactgtgtca tacaccattt 3689881 taatttcctg tgccatttgt gctcacctca ctttttatgt ttttccttct ctatttcatg 3689941 ctctatcctc gtgatttggc gtcttataga atacacatcg ccctctaatg agtggatttt 3690001 tccttctatg ctttcgatga ttccgctgac ttgatcgctt ttgatttgct gatatgcttt 3690061 gttcattcct tcacgaatat cttcaaaccg ctcagcatgt gttcctctcc atgcctcccg 3690121 gttaagatga ggccggtgaa tgagatgctg ggcctcagag aaatcgtgtt tgatttgcct 3690181 aatttcgtgc agcactcgtt ttaattgatg gatctgttcc tgcttttcat gtaagtcggc 3690241 ttttaccgaa tgtaacaaca tttcactatg catgccgcaa cacctcgtgt ttctatcaaa 3690301 ctgtgtaaat tctttacaat acagactatt ttcatattac atgatgggtc atattggata 3690361 aataggtaaa aaggattgtc ttgagaggta tagaactggt tctaaattgc taaaaatacg 3690421 atctcatcac cctatgaaag gagaaaacaa tcatagtagg gactttttat ttaagccttt 3690481 aatctctcct ccagttctaa tttttcctcc cacttaactg tttcttatag tcaataaagc 3690541 tcataaaaaa acaccttccc tcgaaggcgc ttctccatct tatttagatc cccatacagc 3690601 ctcaccgctg gtattcagca cactaaacgt catgacgttc ttctctctca ccgaatccca 3690661 ctggcgtaaa aataccccgt tatacttctt gcctgctaac gtgatgtcgg cggtgttttt 3690721 tccggttttc ctccatgttc cggtcatttc cccggaaatg gtgtggtttt tgttgagctg 3690781 gatgttgatg gtttgtttga tgtcggctga gatgtctttt ccgtgctgga taagtttgta 3690841 tgttcctgtg atgtcttttt gttttacttc tttcaatgtt tcgcccgcat aacgatatgg 3690901 tgctgctacc ggccagccgt ctttgttcat gaacaattgg tggactctga cttcgtgttc 3690961 ttcacccctg cccgggaagc gggtgtggaa gattaaatag gaacgcccgg ttttttcatc 3691021 atagtatgcg gagttgtggc ctggtgagac gtacccggtg cctttttcat tttctgtttc 3691081 aaaagtgtag ctgcccatga gtttgacgcc gtatggttcg atggaacggt cgtcgaagaa 3691141 tgtgcctccc ttgccgcgga cgtcgagcat tggattgcct tctgcatcat agtaagggcc 3691201 gtccggtttc ttggagcggg ccacacggat gttgtagccg cctgttgcat cgagaccgcc 3691261 atatgatagg tataagtagt agtattgggt gtctggattg tagagaacat acgggccttc 3691321 gattctgctg tggttgccgc cgagcagttt tttcccatat ccctgtccag gaagcgggaa 3691381 gcccgttttc ggattcattt caagtatgaa aatgccgcct gagtatgatc cgtacaccat 3691441 ccacagcttg ccgtctttat caaagaaggt atgcgggtcg acgacattcg gatgtttggt 3691501 tgcatcatac ggtgttccat cgctgcttgt gccttccatt cctgatttca aaaagatgcc 3691561 tttgtttttg tatgggcctt cgatgttgtc agcaacggca acacccatgg cggatcttgg 3691621 cgaatcgccg cggcaggcgt tgtagtacat gtagtatttg ccgtccgcca gctgcgtgac 3691681 gtcagccgcc caaagagtat cggattgcgc ccattcgaag gtttctttta attcttcata 3691741 gacattcggg ataagtgggt tgtcattgct tacgctggtg gtcagctgct gccattgcat 3691801 gaggtcattc gatttagctg aagcgagatg agatccaaaa acataaaaag tgccgtttgt 3691861 ttcaatgatg gaagggtcat ggacgctgac ttctttaaat ataggttttt gtgcatagac 3691921 ggagtttggg agggtgaagg ccatgataag agctgcaaga aaacatacac ggaacaatcg 3691981 gttgaacatc taaacaattc gcctctcttt tttattaaat tttaaacgct tacatttctc 3692041 tatgaagata ccccggccta ttaaaacagc cgaatgtttt catattcatc cagataggtg 3692101 atttctcact tcacttacat agtcagactg atgtctgtct gttttgcgca gaacttgttg 3692161 cttgcatatc ctctccttca tagttcaact cttttgctgt ttctccttct tgcatcacgt 3692221 ctgtttttct ttcgcgtaca tgtaataact gctttgtcag gttttgcatc aactgtgata 3692281 cagccatttc gttgtcggcg ttttttaaga tgatgcctga ttgcccgtca acaccagagt 3692341 cattcggctg gctctttata aaacgccttg cgaaaaatac gacttagtaa acgcatattg 3692401 agagttagac agcggcgctt gcctccttgt ctggatatcg tgtgcaatcg ctgaaaaaac 3692461 ctgttctgct ttctgcgtca cgctattaca atagcaatct aacttgttaa agactataaa 3692521 aaaacctttt gacttctgct gctgaaccaa ttaatataat actcagttaa tagttatcag 3692581 aatttttagg aattgagtga ttcatatgac actgcataaa gagcgtcgga tcggccggct 3692641 gtctgttctc ctgctgctga atgaggcgga agaaagtacg caggttgagg agctggagcg 3692701 agacggatgg aaggtctgtc ttggcaaggt aggatcaatg gacgcacata aagtagtagc 3692761 cgcaattgaa accgcttcca aaaagagcgg tgtcattcaa tctgagggtt atcgggagtc 3692821 acatgcgctt tatcatgcga cgatggaggc tttgcatggc gtgaccagag gtgaaatgct 3692881 gctgggatcg ctgcttcgga cggtgggatt gaggtttgcc gttttgaggg gaaatcctta 3692941 tgaaagtgaa gcggaaggcg attggatcgc tgtctcgctt tacggaacaa tcggggcgcc 3693001 gattaaaggt cttgagcatg aaacattcgg cgttggaatt aatcacatat gaaacagccc 3693061 atagatctta gacgataggg ggctatgcgt gaaaacagaa gttcacagca tagctccttt 3693121 ttgtatgggc gctttaccaa agtaaagaaa aaggagttgg gcttatggtg actttagacg 3693181 gttcttcatt gacaacagcc gacgtcgctc gtgtgctgtt tgattttgag gaggcagcgg 3693241 cttctgagga aagtatggag cgcgtgaaaa aaagcagagc agcagtggaa cggattgtac 3693301 gcgacgaaaa gacaatctac ggcatcaaca ccggatttgg caaattcagc gatgtcctga 3693361 ttcagaaaga agactcggcg gcgctgcagc tgaatttaat cctttctcat gcctgcggag 3693421 tcggcgaccc ttttcctgag tgtgtttcca gggcaatgct gcttttgcgc gccaatgcgc 3693481 tgttaaaagg cttttccggt gtacgcgctg agctgatcga gcagttgctt gcttttttaa 3693541 ataaacgcgt ccatcctgtc atccctcagc aaggatcact tggcgcaagc ggagatctgg 3693601 cgccgctttc ccacttggcg cttgcgctga tcggacaagg agaagtcttt tttgaggggg 3693661 aaagaatgcc ggcaatgaca ggcttgaaaa aagcaggtat tcaaccggta acgctgacat 3693721 ccaaggaagg gcttgccttg attaacggga ctcaggccat gactgcaatg ggggtggtcg 3693781 cctacatcga agctgagaaa ctagcctatc aaacagaacg aattgccagc ttaacgattg 3693841 aggggttgca gggaattatc gatgcatttg acgaggatat tcacttagcc cgcggctatc 3693901 aggagcagat cgatgtcgca gaacgaattc gcttttatct atctgacagc ggcctgacaa 3693961 cctcccaggg agaactgcgg gtacaggatg cctattcatt gcgctgtatt ccgcaagtac 3694021 acggtgcgac ttggcagaca ctaggatatg tcaaagaaaa attagagatt gaaatgaacg 3694081 cagctacaga caatccactc attttcaatg acggtgacaa agtgatttcc ggcggaaact 3694141 ttcacggaca gccaatcgcc tttgccatgg attttctgaa aatcgcaata tcagagcttg 3694201 cgaatatcgc agagcgtagg atcgaacgac ttgtgaatcc gcagctgaat gacctgccgc 3694261 cgttcctgag ccctcatccc ggtctgcaat ccggtgcaat gatcatgcag tacgccgcgg 3694321 cctcactcgt ttctgaaaat aaaacactgg cccatcctgc aagtgtggat tccattccgt 3694381 catccgccaa ccaagaggac catgtcagca tgggaaccat cgccgctcgg catgcttatc 3694441 aggtgatcgc aaatacaagg agagtcattg cgatcgaagc catttgcgca ttgcaggctg 3694501 ttgaatacag aggcatagaa catgcagcgt cctatacgaa acagcttttt caagaaatga 3694561 gaaaagtcgt gccgtccatt cagcaggacc gtgttttttc ctatgacatt gaacgcttga 3694621 ctgactggct gaagaaagaa tctttaatac ctgatcatca gaataaagaa ctaaggggga 3694681 tgaacatatg actgatgtaa aaaaatcaat ccgtgccaac agaggaacag agcttgaatg 3694741 cttaggatgg gagcaagagg cagtgcttcg gatgcttcga aacaaccttg atccagaagt 3694801 cgccgagaag ccggaggacc tcatcgtata tggcgggatt ggcaaagccg cacgggattg 3694861 ggacgctttt cacgccattg agcattcctt gaaaacatta aaaaatgatg aaacattgct 3694921 cgtgcaatcc ggaaagcccg ttggcatgtt ccgtacacac ccgcaggccc ctcgcgtgct 3694981 cctagcaaat tctgttcttg ttccgaagtg ggcagactgg gagcatttcc acgaacttga 3695041 gaaaaaaggg ttaatgatgt acggacagat gacggctggc agctggattt acattggctc 3695101 acaaggcata ttgcaaggaa cctatgaaac cttcgctgag ctggcgcgac agcacttcgg 3695161 gggcagctta aaaggaacgt tgacgctgac agcgggtctc ggcggaatgg gaggcgccca 3695221 gccgctgtca gtcacgatga atgaaggcgt cgtgattgcc gtcgaggttg acgagaaacg 3695281 catcgacaag cggatcgaaa caaaatactg cgatcgaaaa acagcatcga ttgaggaagc 3695341 cttagcttgg gctgaagagg caaagctggc aggaaaacct ttgtccattg cacttctcgg 3695401 aaacgcagct gaggtgcatc acacactttt gaaccgaggc gtcaaaattg atattgtgac 3695461 agatcagaca tctgcccatg accctttaat cggttatgtt cccgagggct attcccttga 3695521 tgaagctgac cgtttgcgtc aagacactcc agagctttac gtgcgccttg cgaagcaaag 3695581 catgaaaaaa catgtcgaag ccatgctggc ctttcagcaa aagggctcta ttgtatttga 3695641 ctacggcaac aatatccggc aagtcgcaaa ggatgaaggg ctggagaatg ccttcgattt 3695701 tccggggttt gtccctgcct acatccgccc cttattctgt gaaggaaaag ggccgttccg 3695761 ctgggcggcg ctttccggag atccggcaga tatttaccgt acggatgcgt tattaaaaga 3695821 gctgttcccg acaaataaag cccttcaccg ctggattgat atggcacagg aaaaagtcac 3695881 cttccaaggc ttgccgtccc gtatctgctg gcttggatat ggagaacgaa aaaagatggg 3695941 cctcgccatt aacgagctgg ttagaaccgg ggagctaaaa gcgcctgtcg ttattgggag 3696001 agatcatttg gactgcgggt ctgtcgcctc tccaaaccgg gaaacagaag cgatgaagga 3696061 tggaagtgac gctgtcggtg attgggctgt gctaaatgcg cttgtcaaca cggcggcggg 3696121 tgcaagctgg gtttccttcc accatggcgg cggcgtcgga atgggctatt cccttcatgc 3696181 cggcatggtt gcagtggccg atggaagtga gctggctgac gagcggctcg cgcgggtctt 3696241 aacgagcgac ccaggaatgg gcattatccg tcatgcggat gcgggttatg aacgtgccgt 3696301 tgaagtagcg aaggaacagg acattatcgt gccgatgcaa aaataaagga gtgatgacat 3696361 gccaaagcaa attgatacga ttctcatcaa catcggtcag cttttgacga tggaaagcag 3696421 cggtccgcgg gcaggcaaaa gcatgcagga tcttcatgtg atcgaagacg ctgttgtcgg 3696481 catccatgaa cagaaaattg tgttcgccgg acaaaaaggg gctgaagccg gttacgaggc 3696541 agacgaaatc attgactgtt cgggacgcct tgtaacgcct ggcctcgttg atccgcacac 3696601 ccatcttgta tttggcggat ctcgtgaaaa ggagatgaac cttaagcttc agggcatttc 3696661 atatttggat attctggcgc agggcggcgg gattctgtct acagtcaagg ataccagggc 3696721 ggcttcagaa gaagagctgc tgcaaaaagc ccattttcat ctgcaaagaa tgctgtccta 3696781 cggcacaacc acagcagaag tgaaaagcgg ctacggcttg gaaaaagaga cagagctcaa 3696841 acagttgcgt gtcgcaaaga aactgcatga aagccagcct gttgaccttg tttccacatt 3696901 tatgggagcc catgcgattc ctcccgaata tcaaaacgat ccagatgatt ttctggatca 3696961 aatgctttcc cttttgccgg aaatcaaaga gcaggagctc gccagctttg ctgatatttt 3697021 tacagaaaca ggcgttttta cagtcagcca atcccgccgt tatttacaaa aagcagctga 3697081 ggcaggcttc ggattaaaaa tacacgcaga tgaaatcgat ccgcttggag gtgctgaatt 3697141 agcaggtaag ctaaaggccg tctcagccga ccatttggta ggtacatcgg acgaaggcat 3697201 aaagaaattg gctgaggcag gaacgatcgc cgtcctcttg ccgggcacga cattttatct 3697261 tggcaaaagc acatacgcca gggcaagagc tatgattgat gaaggtgtat gtgtcagctt 3697321 ggcaacggat tttaatcctg gcagctcgcc gactgaaaat atccagctga ttatgtccat 3697381 tgccgcgctt catctgaaaa tgactgcaga agaaatatgg cacgcggtca cagtcaatgc 3697441 cgcatatgcc ataggaaaag gagaagaagc cggtcagctc aaagctggcc gctcagctga 3697501 tcttgtcatt tggcaagccc cgaactatat gtatattccg tatcactacg gggtcaatca 3697561 tgtacatcaa gtcatgaaaa atggaacaat tgttgtcaac agggagggag ccattcttgg 3697621 ataagtaccc ttttctcaga gaggccggat cttcgtttaa agaccgggat gtcacaaaaa 3697681 tgagcgacct gatcgcaaca tgggacggcc aggacattaa gggaccggcg ttgataggtg 3697741 tccccctatc aaaatcctcc atcagtcatt caggcgcttc ctttgcaccc ggaacaatac 3697801 gccaggctct gaaacattca tcagcctatt ctgctgagct tggagagcac gtcgtatcag 3697861 agcttctata tgacctgggg gatatcgata ttcatgtcac tgatatcgta aagtcacatc 3697921 atcacatttt ccaaaccatg cacgctctgc tttcggatca tccggattgg gtgccgctca 3697981 tacttggggg agataactct atcagctact ccacaataaa agcgatagca caaacaaaag 3698041 gaacgacagc ggtgattcaa tttgatgccc atcacgatgt tcgcaatacg gaggacgggg 3698101 ggccgacaaa cggcaccccc ttccgccgcc ttttggatga agagatcatt gaaggtcaac 3698161 atttgatcca gctgggtatc agagaattca gcaacagcca ggcctatgaa gcatatgcaa 3698221 aaaaacataa cgtgaacatt cacacgatgg acatgatccg ggaaaaagga ctaatcccaa 3698281 cgataaaaga gattttgcct gttgttcaag ataaaacaga tttcattttt atatctgttg 3698341 acatggatgt cttagaccag tcccatgcac ccggctgtcc agcgattggc ccgggcggcc 3698401 tctatacaga cgaattgctt gaagcagtca agtacatcgc acaacagccc aatgttgccg 3698461 ggattgaaat tgttgaagtc gaccctaccc tcgattttcg agatatgaca agcagagctg 3698521 cagctcatgt tctgttacac gcattaaaag gaatgaaact ctccccattc aagtgatctt 3698581 ctggcaggtt gtattttggg tataagaaac tcatctgcct aaggaatggc agctaaaagg 3698641 agggcgagac agtgaatctt caggagaaca gcagccaaca gctaaaacgc acaatgaaaa 3698701 gcaggcacct atttatgatc tcattgggag gcgtcatagg cacaggactt ttcctcagta 3698761 cgggctatac gctacatcaa gccggacccg gcggtacgat actcgcttat gtaatcggcg 3698821 ggttgatgat gtacctcgtc atgcaatgtc tcggcgaatt gtcggttgcc atgccggtga 3698881 ccggctcttt tcaaaaatat gctacaacat ttatcggtcc atctaccggt tttatggtcg 3698941 gcatcatgta ctggatcaat tgggtggtga cggtaggctc tgagtttacc gcatccggta 3699001 ttctcatgca gcgctggttc cctgacagca gtgtatggat gtggagtgcg atttttgcag 3699061 cccttctttt tatatgcaac gcattttcag ttaagttatt tgcggaaact gaattttggt 3699121 tttccagcgt aaagattgtc accattattt tatttatcat tttaggagga gccgccatgt 3699181 ttggcctgat ctctttaaac ggaacggcgg atgctcctat gttgtcaaac ttcacagatc 3699241 atggcgggtt gtttccaaat ggctttctcg ccgtttttat cgcgatgata tctgtgagct 3699301 tcgccttttc cggtacagag ttaatcggcg ttacagcagg agaatcagca aatcctcaaa 3699361 aggatatacc gcgatccatc cgtaatgtcg catggagaac cgtgattttt ttcattggcg 3699421 ctgtcttcat attatccggg ttgatttcat ggaaggacgc aggcgtgatt gaaagcccgt 3699481 ttgtcgccgt atttgcggag atcggaattc cttacgctgc tgatattatg aatttcgtaa 3699541 tattaacagc cttgctgtct gtcgccaact caggcttata tgcttcgacc cgtatgatgt 3699601 ggtctttagc aaatgaaaac atgatcagct cccgttttaa gaaagtgaca tctaaaggca 3699661 ttcctttaaa tgccttaatg atcagtatgg ctgtatcttg tttatctctc gtttccagta 3699721 tcgtggcccc tggaactgtc tatgtggtga tggtcgcaat tgctggattt gcaggagtcg 3699781 tggtctggat gagcattgcc ttgtcccaac tcttgtttcg aaagagattt ttgaaaaaag 3699841 ggggggatgt aaaagatctg acatttcgca cgccgcttta tcctcttatg cctatagccg 3699901 ctctcttatt atgttctgct tcttgtatcg gtcttgcttt tgatcccaat caaagaatcg 3699961 cacttttctg cggagttcct tgtatcatcc tttgctatct catctaccat ttcaaaagaa 3700021 atgttacaaa agcgaaaaaa atcagccaag aggaatatcc agccgatcac atcctataat 3700081 taaaaaagca caccccgctc agcatgggat gtgctttatt ttttattctg taattaacgt 3700141 atgaatcagc ttcggcgcct tcgcttccgc ggcgatgcgg atgttgtcat agacttttgc 3700201 gatgacttca tcgacgtttt ctcggttagc gtaaagcgtt acgagcggtt cccctttttc 3700261 tactttgtcg ccgacctttt tgcggagcat gatgccgacg gctaaatcga tttcgtcttc 3700321 ttttgtggcg cggccggcac ctaacagcat cgccgcgacg ccgatttcgt ccgcgacgat 3700381 ttcagagacg acacccgctt ctttggcagg cacatcaatt tgatatgcgg cttgcggaag 3700441 cttagacgga tcgtcaacaa ttgagctgtc gccgccttgg tttttcagga aatccttgaa 3700501 tttctcaagt gctttgccgt ttttcatgac ttcttccagc ttcgctctcg cttcgtccaa 3700561 tgtatcggct tttttcgcaa gcacaaccat ctggctgccg agcgttaaga caagctcatg 3700621 aagatcctca ggcccctcgc ctttgagcgt gtcgatcgct tctttgactt caagcgcatt 3700681 tccgatcgca aagccgagtg gctgggacat gtctgaaatg acagccattg tttgacggcc 3700741 gacgttattt ccgatgcgta ccatcgcttt ggcaagttca gctgcgtctt cttctgtttt 3700801 catgaaggcg cccgctcccg tttttacgtc aagcacgatg gcgtccgccc cggcagcgat 3700861 ttttttgctc ataatcgagc ttgcaatgag cggaatggaa ttgaccgttc ccgttacatc 3700921 acgaagcgcg tacagttttt tatcagccgg cgttaaattg ccgctttggc cgatgaccgc 3700981 aaccttgtcg cggttcacaa gtttaataaa ttcatccttc gtcagttcca cgtggaagcc 3701041 catgattgcc tctaacttat caatcgtgcc gcccgtatgg ccgaggccgc ggccggacat 3701101 cttagcaacc ggcacatcaa gagccgcaac aagcggagcg agaacgagcg ttgtcgtgtc 3701161 gccgacgccg ccggtagagt gtttatccac tttaattcct tcaatggcag aaagatcaat 3701221 cgtttcaccg gagttcacca tagccatcgt caagtccgcg cgttcacggt cactcatatc 3701281 ctggaagaaa atcgccatag caagcgcgct tgcctgataa tcaggaatgc ttccatctgt 3701341 atagccgttc acaaaaaatt gaatttcttc agtggtgagt tcttttccgt tttgtttttt 3701401 gatgatgata tctaccattc tcatgtttgg tcaccgatcc ttttcgatta agttcagtaa 3701461 atcaagccca caattgctgc tgataaaaag ctgacaagcg tagcaccgta taataatttc 3701521 aagccgaaac gagcgacgac atttccttgc ttttcattca gtccttttac ggcaccggca 3701581 atgattccga ttgaggagaa gttcgcaaat gacacaagga ataccgatac gatcgctgtt 3701641 gtacggccgc tgaaatggaa accgttttgc gtaagcgacg tcatggcgac aaattcattc 3701701 gataccattt ttgttgccat aatgcttccc gcattaacag cttcattcca tgggataccg 3701761 acaagaaaag cgaatggagc aaacacatat ccaagaatgc cttggaacga aataccgaat 3701821 actgcattaa aaatgccatt gatcaatgca ataatcgcga caaatccaat cagcatcgca 3701881 gcgacgacaa ccgctacttt gaaaccgtca agaatgtatt ctccgagcac ttcgaagaag 3701941 gattgttttt cttcttcctc aacacgaagc atatcctctt cttttgcaac ctcgtacgga 3702001 ttgataatag aagcgataat gaaaccgcca aataagttca aaacaagcgc tgttacaaca 3702061 tattccggtt tcagcattgt catatacgca ccgacaatcg acattgatac agttgacatc 3702121 gcagatgcgc aaagcgtgta caagcgctgc tgatttaaaa gaccgagttc tttcttcaag 3702181 gagataaata cttctgactg ccctaaaatc gcagaagcca ctgcgttata cgattccaat 3702241 cttcccatac cgtttacctt gctgagggca aggccgatat atctaatgat aaacgggagg 3702301 actttccact tttgcagaat cccgatcaga gcggaaataa acacgattgg caagagaaca 3702361 ttcataaaga atgtcgtttg gtccgcattc accaagccgc caaacacaaa gttaattccc 3702421 tctgccgcgt attcaagcag gtaaccgaat ccttttgcaa atcctcccac gaggaaattc 3702481 cctattccgg tattgaggag aatgtagcca agaataaatt gcaaaatgag cataacaaca 3702541 attgggcgga tcttaattct ttttttgccg ctgctcgcga tccacgcgag gcctaaaaac 3702601 acgattaaac cgataatccc aatcaaatac ttcatatgtg tttctccttt atttgtattc 3702661 gcttacaatt actgtttcct cagaaaacgg aaagcagtct gccttccgtc agctcttaat 3702721 agttgtctcc gcctgatgca ttttctcctt ttacgataga aacgcctgcg ctggcgccaa 3702781 ttcggcttgc tccggcctct accattgtgt ctacatcttc tttcgttctg acgccgccag 3702841 atgctttcac gccgatatca ggccctactg ttttgcgcat taaggcgata tcttccttcg 3702901 ttgcgccgcc tgtagaaaag cctgttgatg tttttacgaa atccgctccc gcagacaccg 3702961 ctaaacggca tgcacgttct ttttcttcat cagtcagaag gcacgtttcg ataatgactt 3703021 tgacaagcgc ttttccggct acagcttcca ctacaccgcg gatatcagct tccaccacat 3703081 cgtcttcctt gtcttttaaa gcggcaatat taatgaccat atccacttca gtggcgcctt 3703141 ttgaaatggc gtcttttgtt tcgaacgctt ttgtttcagt tgtattggca ccgagcggga 3703201 agccgatgac cgtacaaacg tcgactccag ttcccttaag ctcttttgca gcaagctcca 3703261 cccatgtcgg attgacacat actgaagcaa atttgtatgt tttcgcttct tcaattagtt 3703321 ttagaatgtc cgctttttgt gtatgcggtt tcaaagctgt atgatcaatt atgttggcta 3703381 atgacatcct tcgcacactt ccttttttgt taagatattt tttagcataa ccgacttttg 3703441 aacatatgta aattggtaat tgaaattttg ttcaatgaaa ggtttgaacg tgtcacaaat 3703501 cattaacaag cgccctcgcg gtatgctggt caatgattaa aacgttggca tattttccgg 3703561 ttaatgctcc gtgaatggaa gatacttttc tgcttccgcc ggcaactaaa atggagcgtt 3703621 ccttcagtct aaggtcttga agctcaacac cgatggtccg gtcattgatg gcgctgctgc 3703681 aaatattccc tttcgcatca aaaaagcgtg aacaaatatc cccgacggcc tgttttttca 3703741 gcagggcttt ctcttcttcg ttaaaatatc cgagccgaaa caacagcgct tcatcacgga 3703801 cagtcccgac cgtaaagaga gcgatattcg cctgcttgcc catctcaatg atccgttcaa 3703861 tatgacggtc tttctccacc attcgcttca catccgcatt atcaaacacg acgggaagcg 3703921 ggagatagcg cggcatcgtt tgaaaagcct ctgcaaacag ctgaatcgtt tcagccgaat 3703981 acgtgtttac ccgggaatgg ctgatgccgc ctttcagctg gacgacctcg acgcctttta 3704041 cctgcttcgg ctgcatgttt tgcgcgattt gatacatggt ggttccccag ctgacgccga 3704101 caatgtcgcc gtcttttacc gtttcatgca tatattctgc accatagcgg cttaggtcat 3704161 gtgtaattcc tgcataatcg ggtgtcgggg aaaacacaac atgcgcctca aggagcccgt 3704221 atttctcttc aagtatggaa ccgagcgcat ccaaatcctc aaaagggtcc atgacgcgaa 3704281 tctggacata ccctttttcc tttgcatatt gcagcagccg ggaaacggtt ggccttgaaa 3704341 tgttgagctg ctcagcaatt tgctgctgac tgtagtcaga ctgatagtaa agccttgccg 3704401 cttctatgct taattgctgt ttttcccgat ccattctgca cctccctgtg gatcagtcct 3704461 gataaaactg cttttgattt gcttttatta tacaggctgg cgccggcttt catccacctg 3704521 atttctaaga aactgaaaaa cgctctgggc gcggacctgc ccagagctta cttctcccaa 3704581 gtcatatgct gataaatgcc tttcataatg gcgtacattc catataggat caggcctaat 3704641 gccaatatag acagaatcaa tttgccatgc ggctgctgcg cgagttctgc gagcgcgccg 3704701 tcaaagcctc ttgtgtcgtc gggatcagcg gtcatggctg tcttgatgag aaaatagccg 3704761 atagccgaga aaataatggc ccgggcgata ttgcctgcgc gtcctgtgtt tttcgtgatg 3704821 catatcatct gtttgttcat ttttgatgta tcgaattctt tcataaaagc agcccgaacg 3704881 cctttcataa attgaacaat cgcaaatacg ataaaacccg cacccgtaag ccctgtgagc 3704941 cattggccga acggctgcgc caatacataa gcggaccacg tctgttctga agtgccgccg 3705001 tccccttggc caaacacaaa tcgcaaggca ttccaagcga tggatgtgta aacagcggca 3705061 ctgaaaaagt ttcctattct ccgcgacagg cctcgcctgc tgtttccgtg cccctccgtg 3705121 tccttgatcg cgcttaacac catccagatc acatagccga taaggccgat gcctataaaa 3705181 aaaagcaata gtgacccata cggcatgcgt gatagcgttt ggagagctcc gctcgaatct 3705241 ttggcgcggc ctgccccggc agccgtcata aaagccaaaa ccccaagcag aataaaaacg 3705301 ccgccgaatg caaaataacc aagcctcccg aatcgtttga tccaaggctt ggtttcctgt 3705361 tttatttttg acatgtaccg gtctttcacc gccatgtgtc caaccctctt tcacagaaat 3705421 ctttactgta acattcccga ttgaacaaag ttgaaacagc tcctgcctca gctatggctg 3705481 gctgagatac gtttttgctg tttagctgat tgtgcaggtg tcatccaagc agccgctgcg 3705541 gcagctgtga ctccgcctgc taatttccca atgatcatgg ccgccgccat ttcttttttc 3705601 attccagcta caaaaccgag atggctgccg agtacaaagg cgccgctgac cgcaaacgcg 3705661 acattgatga cctttcctct cggcgtcata tcctttaatg aagccagcat tgggatatga 3705721 tgcgccaaag aggtcactaa gcctgctgtt gctgtctcat ctaaatgaag gcatttcccc 3705781 agagcctgaa gcggtttttt aaaggttttt gtaataaatg ccgtcatcgg gaacgcccct 3705841 gccagagcaa tggcgatggt ccctgtcgtt tgtatccctg tctcgacatt ctccattccc 3705901 ggaatcagca caatgccggt catcgtttca acagaaacag ctgcaagccc gataatcgca 3705961 accatactga ccgctttccc gaagagatga aacaactgaa tcattctgtc ggtgtatcgc 3706021 cataacccaa aagcgatgac agcagataac agactcggga tcagaagatt tttacctatc 3706081 atgccgatgt caaagcctgc gcataatccg ccgattaagc aaccgatcgg cactgtgcac 3706141 agcccgatta atatgccttt cgcaaaatac ggatgatcct ctttttcgat gatgccaaga 3706201 gcgacgggaa tcgtgaagac gattgccggc cccatcattg ttcctaaaaa cacccatgaa 3706261 aacagcccgg cctgcggatc tttcgccatt tctccagcca gcgcatatcc tcccatatca 3706321 atcgccaaaa tggtgttcgc aaaggaagaa ggatccgcgc caatcgctgt gtaaaacgga 3706381 gcaacaatgg gaatcaagat tgctgccagc acgggcgcca gcgatacaat tccgatcatg 3706441 gacagcgcca gcggccccat agccttaaag ccgtccgcaa accgctcgcc tagcccccat 3706501 ctgtttccca aacaataatc cgctgctccc catagtaaaa aggcagccaa aatgaataca 3706561 accgcgtcat tcaccgtcat ggttttctcc tttttcaaac gtatgattgg ttttatcata 3706621 tcatctgaaa tcaccgaata gagttgatct tattcaatat gagctaaaaa ttcttttata 3706681 tcggcttttt caacggctgt tataatgcgt cgcgcttttt cttgcgggac cgttaatgtc 3706741 aatttttcta ttatgtcttc ttcagacagc tcatttcctg gtgccccttt tgggcagtcc 3706801 acacgcgctt cgcaaatccg gccgtctgat aaataggccc ggacaatcgt gaaacggcct 3706861 tttggaacgg catgaggagc cggctgaata gcattgtcat atacgcgctg aattcgcccc 3706921 attgtcgttt gaaccccgtt tgggatcggc tggctgctga aatgttcaac ggtcaggccg 3706981 tgtccatgca aagcaagagc aatcacatat tcaacgctga aacggccttc ctctccagct 3707041 tttggagatc tttccgtcaa tgcagcatct ccgcctggcg gaaatatcac ttcaatacgt 3707101 tcggtattgg cagcagaaat ggtttcttcg gagataagct gtcgtaccgc atctgcagca 3707161 tggtgtgccg cggaacaaaa tggatagatt ttaaaccata gacccggctg cacaattctc 3707221 cacggtgccc cccaatcgtt tagcaaagtg tgttgtgctt tctcaacgtc accgtacaga 3707281 ctgaagaaac cagtttctcc atcaagtgcc gtgcgggacc cgccaaattc tgattgggcc 3707341 agcttaacgg ccagcaagcc agcctgagcc gccaaaccgg cgtgcagcgg tttcatttct 3707401 gttccaaatt gcaccctcat cccagcagat tgcgtagccg caaaaccaat tgctttttcc 3707461 aactcttcct gagtcagctc ctcagcataa cctacggcgc aggcagcagc gatggcacca 3707521 agcgtacctg tattatgcca gcccttctca tagtggcggc tgccaattga ttctcccagc 3707581 cgtgccatca cttcaacacc aacaacataa gcgccaagaa gccgctcgtc atgtccgcga 3707641 gcggcagaag caataagggc cggtacgatg actgcactgg ggtgtcctct tacatcggag 3707701 tggacatcat caaaatccaa tgcatgggcg ataaatccat tgagcatcgc ggattgtaat 3707761 ggcgcggcct ttttgccctg tccgataaca ggaacaaggg gccggcctcc ttcatcctct 3707821 atcagacgga ggagcttttg aattccttta tcttctcttc ctgcgaatga agcggcagta 3707881 aaatcaagta atcccttttt tgcttcgtga atcgcgtcaa ctgaatgctc aggttgtgac 3707941 gttctcacag cctctgcaag acctgctgtc agcccttgtt tgctcatttg atggtctcca 3708001 atacaataac cgccagctcc gcaaagtatt gagaggcaac cgtaagggct tcttcatcca 3708061 gtgtaaaggc cggatgatgc cactcctccg tcccgttcgt tcccatccag acaaaaaatc 3708121 ccggaatctt ctcttgatac agagcgaagt cttctccgcc cggagactgc tcagcgtgaa 3708181 cggtttgata gccaagccgt gccgcagctt cggatgccgc attcaaaaat gtgccgtcat 3708241 tctgaacgga aggcaaataa ggaaaccact tgaattctgc ttgtgcccca tagcccgctg 3708301 caattccttc agccactcgt ctcatatgct cgggaacagc ctgcctcgct tctttttgaa 3708361 aggttcgaac cgtcccctcc atttcagctt ggtctggaat tacgttccac gaggtgcccg 3708421 cctgtactct tgtgatactg acgactgcgt tttgcagtga gctgatattg cggctgacca 3708481 cagattgcag cccgctgatg atttgtccgg ctgcagcgat tggatcaata ctgttatttg 3708541 ggatgccggc gtgcccgcct ttccctttga tgacgatctc aaatcggtca acacttgcca 3708601 tgagcggacc ttcctttaca ccaatggtcc cgacaggcag atccggctta ttgtgcatgc 3708661 cgaaaatcgc agaaacgcca ttaagtacgc cagcttctag aacctttctt gctcctgcgg 3708721 caatttcttc ggccggctga aagataaagc ggactgtacc tttcagctcg gcccttcttt 3708781 gattcagcaa catcgctgtg ccaataatag aagcagtatg aaaatcgtgt ccgcacgcat 3708841 gcattgtgcc atcaacctta gatgcaaatg gaagattcgt ctgttcttgg atcgggagcg 3708901 cgtcaatgtc cgctcgtatt gctatcacgg ggccgtcttc ccgtcctttg atttctgcaa 3708961 tcacaccagt cttcaattga gggacatcaa gtatttcgat ttgctcctcc tcaagccaac 3709021 ggcggatttt tttcgtcgtt tcaacctctt gaaatgacag ttcaggatgt tcatgaagat 3709081 cacgccgcat attgattaaa cgggtatgaa acgctttgtc ggccattgtt cttctcccct 3709141 tcttatataa gctctgcagg ctctcccacc tgcttgataa atcgtttcgt ccgttcgttt 3709201 ttcggatggt caaacagttc ctctggcgtt ccctgctcga taatatggcc gtctgccata 3709261 aaaatcactt gatcagcaac ctcttttgca aacgccattt cgtgtgtaac aatgatcatc 3709321 gttgtttgtt tttccgcaat ggacttgatg acctgaagca cccctgtgac gagctcaggg 3709381 tcaagcgctg acgttggttc atccagcaaa atcgcatgcg gattgaccgc aagcgcccgc 3709441 gcaatgccga ttcgctgctg ctggccgccg gacattgtga ttggatagct gtcagcctta 3709501 tgctccagac cgacttgttt cagaatctcc attccaatac gtttcgcttc gtcgcgtggt 3709561 ttatgttgag ccacgattaa agcttctgta atgttttgca gagccgtttt atttttaaac 3709621 agattgtagt tttgaaagac catggccgtt tgctggcgaa gccgatgtgc ttccttgcgt 3709681 gtaaactttt ccgcattcag tttggcttct ccgatttcaa taaggccttg atccggacgc 3709741 tctaatagat ttaagcaccg gagaagcgtt gattttccgg aaccggacgg accgatgatt 3709801 gccaccactt ctccgcgttt cacttctaga tcgattccgt cgagcacgac gagatcttta 3709861 aacgctttgc gaatattttt tactgttatc aactgatttc acctctaagt ccggtatggc 3709921 ttgctcatgg cacgttcaaa caagtcctgc aaaatgctgt agataatggt aagaacccaa 3709981 tagacgatcg caaccgccaa atacgtctca aaatatttga ggtttcctga agcgtacatc 3710041 ttcccttggg cgaacatctc catgacccct aatgtaaagg ccagtgacgt ttctttcagg 3710101 agcccgataa atgtattgcc cgttgccgga atcgcatttc ggatcgcttg cggcaaaata 3710161 atccgtctgt atgcctgaaa ttttgtcata ccgacagaca ggcacgcctc cagctgcccg 3710221 tcatcaacag aattgagggc ggcccggaag atttctgcca aataagctgc gttttttaag 3710281 cttaacccga tgatggcagc tgtgagagct gtcattttgc tcatctctgg aaatagctgc 3710341 ggcagcccgt aatagattaa gaacagctgt acaagtgtcg gcacgcctcg gaaaaaggat 3710401 atatacagct ttgacagctg atgaagcact ggaattttgt tttttgtaat gagtgcgaga 3710461 ataagtcctc cgataatggc aaaaatcata gctgctattg ccataaacaa ggtgatcgga 3710521 agggcctgaa ttaaagtcgg gaacgctgat atcatgaatt cccaatcaat cgtgttcatt 3710581 ctggtgagtc accgccgttt cttaatgctt ctgttctact gtgatatctt cattaaagta 3710641 tttttcagag agttttttca gtgttccgtc tttacgcaat tcatctaggg ccttattgac 3710701 ttttttgcgg agcttgtcgt gcgcatcgtc cttggcaaat gggaatgcaa cctgttcgta 3710761 aacaatcgga tctcctgcaa gctttaatgg caaaccggtc ttcttgattt gcgcgatcaa 3710821 tacagttcgg ctgttgacat aagcgtctac acggccgtac gcaacatcct tcagcgtacc 3710881 ctcttgtgtt tcgtacgttt tgatattgat ttttttatca ggatctttgc tttcaaggtt 3710941 tttcgcgtgg tttgaaccga gaacggctgc gactgtcttg ccttttaaat cgtctactga 3711001 tttgatgtct gtattgtctt ttttgacgac aatctgtgtt cccgcataag cgtatggttt 3711061 cgtaaagtta tacgtttcct tacgttcgtc tgtcacagct acctggttgg aaatggtgtc 3711121 aagcttgcct gtttgaagct ctcccatcag cccgctgaat tcaagcagct tccagtccag 3711181 tttcatgtca attttcttag cgactgcttc catcacttcc acgtcaaagc ctgtcagctt 3711241 tccgttttct ttataagcaa atgggtaact ttgtcctgtc gcaccgacat gaagcacatt 3711301 gtcatcctct ttactgctgc tgtttccatt gccgcaagct gagagcaccg ctaataatgc 3711361 agcaacgacc agcactgtcc attttttcat cttcatttga ttttcccgcc ttttctattt 3711421 ttatagatca tgtcgcaatt gttttttcat atagactgtg atatgccctt ttccaaggtc 3711481 ttgttcacct gagcggacat atccttttcg ttcgtacatc tcaatcagcc acggatgctt 3711541 atccgctgtt ccgagtgaga caaacggaac ctttaacgta tcgcgaagga ttgtttcctc 3711601 cagccattga agcagctttg ttccgattcc ttttttaccg gtgtcggggt ccacagcaaa 3711661 ccaccagata tgcggaacgc catacggtcc cggctgtttt ccccaaggca ttctcaaggt 3711721 gatggtcgcg atgatccgcc cgtcttcttc catgacgtag caagcatttt cccgaatatt 3711781 tttcagcacc aaatccaaat ccgcatgagc agcagcaaaa cgaatgccga gctttcgaat 3711841 cggttcataa gcccgcaatg tcagctcgag aagctgttcg gcatcacgtt caactgcaag 3711901 gcggtatcgt ggcttcatct agcgttcctc cttactttgc atagcggttt accggctttt 3711961 ccaaaccgaa gtgctctcgt aatgttgtgc cttcatattc ttttctgaac acgccgcgct 3712021 cctgtaaaat cggaaccact tgatcaacaa acacttcaat tccttctgga agaagcggag 3712081 gcatgatgtt aaacccgtca cacgctttcg tatccaccca ttcctgcatc ttgtcggcga 3712141 gctgctccgg cgtgccgacg aagatatggt ggcctctgga gcctgcaacg tatttgtaaa 3712201 gctctcgtat cgtcatattg tcacgttcag ccatctcctg aacaagcttg aagcggctct 3712261 tcaccgcatt ggaagcttcg gcgtcaagct tcggcagcgg cccatcaagc ggatatgccg 3712321 acaaatcaat tccgcctaag taattttgga gaatttgcag accgacagat gggataatca 3712381 gatcttggag ctccttgtat ttggcttgcg ctgcttcttc tgtatcggca atgattggga 3712441 aaatacccgg cataatggca attttttctg gatcacgtcc gaattccgca gcctgttctt 3712501 taatggattg ataaaattct tgagctgatt ccaggtggtt ttgtgctgtg aagatcactt 3712561 cggctgtttt ggcagccagc gcttttccgt ctcctgatga tcctgcctgg ataatgaccg 3712621 gctggccctg cggggttctt gaaacgttta gaggtccgcg aaccgagaaa tattctcctt 3712681 tgtggttcag ctcatgcatt ttttctttgt caaagaattc acccgtttct ttattacgga 3712741 taaaggcgtc ctcttcccat gaatcccaaa gcccctttac aatctcgaca aattcctctg 3712801 cccgctgata gcgcaaatgg tgttcaaggt gcttttcacc gctgaaattc agcgctgttg 3712861 attcaataga tgaagtgacg acgttccatc cggcacggcc attggacaga tgatccaatg 3712921 acgcaaactg tctggcaata tggaatggct cgctgtatgt agtggaggct gttgctgtca 3712981 gtccgatttt tgatgtgacc tgcgccaaag cagagagcag ggtgaatggc tcaaaccttg 3713041 ttaatacatt tggatgtgat ttgctgtcaa ttgaaaggct gtccgctaaa aacagcatat 3713101 ccagcttgcc tcgctccgct gttttcgcaa gctctttaaa ataatccaaa ttcatgctcg 3713161 catctgacgg cgcgtccggg tgccgccaag acgcaacatg atggcctgta cctgctaaaa 3713221 atacccctaa tttgatttgt ttctttttgc ttgtcatggc gatactcctt ttatcatgtt 3713281 tttaggctga ataatccgaa aaataaactc ctatattcct agtcgtttaa tatgaataaa 3713341 tcaaaatgta cctttgtctt ggacgtttgt caatgagtta agattaattt tttctattca 3713401 agcgaaaaga cccttgcgtg accatgaggg aacggcattg attcattcaa ctagtgcaac 3713461 ctctatatcg gcaagaaaac tgagtctaat gaagcaaaga ctcagttttc ttccaataat 3713521 ttcatataag atttcgccat ttcctttgcc ttttcttcgc ttttgcaaac cgcctatcca 3713581 ttcagacgcc gtaacgattg tataaaaaaa cagctgactc cagatattca aaccggaatc 3713641 agctgattga tgtgaattaa ttaagctcat gaatactctc ttctgcttta gcggaaaaca 3713701 ctttaggctc caaacagtca aggtcttcat gaaataaatt tactttttgg atttgccgat 3713761 tgtcatagtg gtggaaatag tagtttccag tttcgttgca catcacggaa gtatattgcg 3713821 tataatgaat ttcgtcttct tccgttatca ctgcgccctt tggtatcgtc atatttgcca 3713881 aaatttgaaa agcggctgtt acacctttcg tttcatcggc cgccggctct agatgttctt 3713941 tcaaataaac agctctgaca aaccgggaag gcggtgtata atcccccggc agaccaacag 3714001 ttcctaagcc ttggccaaaa gcagaaaggg ctaatccgcc catctctttg ctctctaatt 3714061 gcttcggtct gattcctgta tattgctgca gattggttac atgccatata aagtcggggc 3714121 tgttcgtcat gacaccaggt tgattatcat agactttgag gccgtctgct cttggttcta 3714181 tcgtcaggtt tcggcccgtc cggtctgaca atatccagtg aagcggtaaa actgtatcca 3714241 atagatctaa ttttttctct acaatcgtta aagatcgaat cttttctttt acgtcttcca 3714301 aagactgaca gactgacagc acccatgtca caaactcatg cgggacaatg tgaacggtat 3714361 cttcccgtat cgttttttcg tactccgcat agcccggaaa ataaagcgcc gcacaagata 3714421 aaccgctttc attaatgccg tcggcaaata atatatttcc aagttttctc cccataccga 3714481 taaacgcgta ctgtgtctga tgggcccttc cgtcagcttc actgttccag ctgtaacggc 3714541 gcggatagag aatcacctct gtccccagct gaaatgcaaa atccattgtt cttgctaata 3714601 catgtttacg gtcagcagtt tccaatgtaa gacttgtgca catttgatca gtcccctttt 3714661 caattcagat taatatcata catattgtga acgaattggt tttatcagca taacgaaagt 3714721 caaatcgatt cgtcaaagaa ttgacattac atcaaataaa acgaaaaaat ccagccttta 3714781 gaaggctgga ttttttatta tttagccaaa acaagctcgt gaatcgcatg tgcaacgcca 3714841 tgttcattat tggagcgtgt ttgaaagttt gctgcttcca atacttctgg gatggcgttt 3714901 gccatggcaa ccccgcagcc cgcccattcg atcattgtca ggtcgttccc gttgtcgcct 3714961 atgcacatga cttccgcctg ttcaattcca agcagctgag ccagctggcg tacagcattt 3715021 cctttgctgg cttccgagtg cagaatttca taaaagaaag gcgcgcttct gaccattgta 3715081 tatttttctc tcacgtcttt tggaatcgat gtaatgacgc ggcttaagtt ctccggttta 3715141 tcaataaaca tcactttcgg gatgaggata tcttttggca cctcgtcaat cttgcggaaa 3715201 tgaagcggca cctgtgtcac ataggattcg tatacggtaa attcgctaat atcccggtta 3715261 ggcgtataca aattagatga gtcaaagaaa tgcatcggcg tcttcagctc taagctcagg 3715321 tcatataatg aagtcaaatc atcataaccg agagacagct ctgagaccac ttcatttgta 3715381 tgcgtatttt gaacaagtgc tccattatac gcaataacat agtcgccttc ttcaattaaa 3715441 ttcagttcat ctaaatatct ctgcacaccc ccgataggcc ggccggtgca aagcacaatt 3715501 ttgacacctt ccgcttttgc cgcgtgaagg gcgtcgcgga cctcctctgt tacttcatga 3715561 tgatcattta aaagtgttcc atccatatca attgcaatta gtttgtacat cctgcatctc 3715621 cttcatgtcg ttttcaggct atagtcccat catatcgttt tttctttttg atattcaacc 3715681 ggaagagatg gttttctccg gattctgttt agacgccgcc cttgtcttcg gatacgcaag 3715741 cgcggtttcc gctttctttc tgccttgacg ccgttttctg cttttttctg tttcatcagc 3715801 agaaagccgg cagctagaaa aggaatgccg gttatattca agatggcaag cttcacaccc 3715861 gccgcgatga aaaagaaccc ccatgaagat gatggattcc gtctgatcat gacgtaagcc 3715921 gccatttcca gaacgatcag gatggcatga agcactatgc cataaatcag caatacaagg 3715981 gcaaaaaaca aaacataatt cacgattgcc cctgagtaca tcatagcgcg catcatttgt 3716041 ataaacgata aggactgcat ggagccgctg atgacattag ggttatagat cgtatagtca 3716101 ctaaataaat gtttgacttt gagaaaagcc cataatataa atatccattg aatgatatgt 3716161 aaaacaagcc ccgctgccac cagtctttca gctttttgat ttctcatctt tctcctccct 3716221 gccggtcttt gattcgattc ttgtcatcgt ttttctctgt ccattttgct cccatatcaa 3716281 tgtcccgttt tctcctcttt tcagcgtgct tttgagcgga taataagggc cgaggtactg 3716341 aatctcgata gacccgtcag tgctttggga aatcaccttg tatgccataa aaggcagctg 3716401 tacctctcct cttccttcca tcacttccgt ttccacaacc tcgtcttcgg taaatgtgac 3716461 tgttgctgat ttcacaccgt ccgttggccc gggggcacgc ccctcatccc acgttccgta 3716521 ataaaacggc gtctcttctt tttgctgctg gcagcccgat accatgatgc atacagcaat 3716581 taaaaacaaa atgccatatt tgtttctcaa ggggatcacc attctttcct ccttttttgg 3716641 gcgaatgccg tgccactgtg ccaatgacta cataagttat aaggaattca cccacaagga 3716701 gactgatcac atgaaccctt atcaatatta cagccctcag ctgcctcagc aggaacctta 3716761 ctatagccac tatgagtaca atccttatcc gcagcaggat gtatacgatc cataccaaat 3716821 ggacagacag ccggcattgg aaagaagaat cgcagcactt gaacggcaaa atgaacagca 3716881 gtcaagagaa ttaacccgtc tgacaaacga agaccgccgt caaaatcggg aaattgcacg 3716941 gattgccgaa caggtcaatc agttaagcca ggctgttgaa cgccatacac gccgcctaaa 3717001 tcggctcaat cagcgcctcc gtacagtaga aaaccggctg aatatcccat ttactgcagg 3717061 ggaaggcggt ttctgagcga aacaaagaaa aaaagcggaa tacgattctc ccatctcagg 3717121 gtttcgtttt ccgcatttct tatatgttaa aacggaacat ttacataaaa agggtttgta 3717181 cccagtatac aatctttacc gttttcattc aaagatagag gggctgagga aaataattgt 3717241 agttcctctt tgacggaatt tcttttcatt caagttgcat gataataccg actcacgtca 3717301 atcgatacat ggagggatca ttcatgcata atacacaaca cggcttgcag cagctgaacc 3717361 aatgccgcca aactgctcag cagctcattc agcaaacaca gcaaagcagc cagcaatatc 3717421 gccaaatgct tcatcaggaa cagcaaaaca tccaaatgct gcagcagatt ctaaaccacg 3717481 aacaacaagc tgcacatacc attcagcaag cactgcacgg gcatgacatg gcgattcaaa 3717541 agtgccagca ggttgtcaac atgtgcaacc aaatgcaaca ggaacttact ggacaatcca 3717601 gcgtcatgaa tacgaatgtg tctacacttc cattcggcca aaacacgaca tttcagcagc 3717661 aatcctacca gcagtaacat ataaaaagct caacacaatg cgagtgttga gctttttttc 3717721 ttactgttct ttgcgaatat gtatatcctg aatagactgt ttcggtgcat gaaatctgct 3717781 ctcggcttca cttcttgcct cggcaaaagc ccgcgcctcc acatgatctt tgtagacatc 3717841 cagctgaatc aaatacagcg ggcgcacttt aaatccatga ataatggtta ccgcccataa 3717901 cgggaccaca ataaaaacac cgggcagatc gggcaaaaca aaaccaaacg caaaaatgaa 3717961 aaaataaatg atgccgtaca tgatccactt tctatttcta accttgatgc caataaataa 3718021 aaaggcaaaa aaactggtaa tggcaaaagg catgaaaata aacagcatcc accagctatg 3718081 cagccattcc caagcggcac ctctttttgt aattcccata tttttctcct cctatttacc 3718141 tataataatc gattaggcac accgcgtcac ccataaacgg gaaaaacttt ctcccttaaa 3718201 aatagtgata gacggagaac aggtttcttg ctatattatt aattgataat gataatcatt 3718261 actaatctat tgagatacat agtgggaggg ttcttgatga aaaagaacat attgctcgtg 3718321 ggcatgcttg tgctgcttct catgtttgtc agcgcttgca gcggcacggc ttctaaaggg 3718381 agctcaagcg attctgcttc cgaaaaaaca gaaatgagaa catacaaatc accaaaaggg 3718441 aacgtcaaca ttcctgcaca tccgaaacgc atcgtcactg atttttatgc cggtgaattg 3718501 ctgtctgtcg gggccaatgt ggtcggctca ggctcatggt catttgataa tccgttttta 3718561 aaatcaaagc tgaaaaatgt gaaggatgtt ggtgatccaa taagcgttga aaaagtgatg 3718621 gagcttcagc ctgacttaat tgttgtcatg aatgaagaga atgttgataa attaaagaaa 3718681 atcgctccga ctgttgtcat accttataac acagcgaaaa acgtagaaga cacagtcagc 3718741 atgttcggag atatcgccgg agcgaaagac caagcaaaat cctttatggc tgactttaac 3718801 aaaaaagcgg aagcagctaa gaagaaaatt gccggcgtca tcgacaaaga tgcaaccttc 3718861 ggcatttatg aaaacacaga caagggcgaa ttctgggtgt tcaatgacaa tggcggacgc 3718921 ggcggccaag ctgtatacaa tgcacttggg ttaaaagcgc ctgaaaaaat tgagcaagat 3718981 gtcatcaaaa aaggagagat gaaacagctc tctcaagagg ttattcctga gtatgccgca 3719041 gattatatgt tcattacgga ttacaacccg aaaggcgaaa gcaaaacact cgacaagctg 3719101 gagaattcct ccatttggaa aaatcttgac gctgttaaac ataatcgcgt gtttatcaat 3719161 gactttgact cgttctaccc gtacgacccg atttctgtca gcaaacaggt ggatatcatc 3719221 accgacatgc tgatcaaacg ggccgaagaa aataaaaaat aaaaaaacgg cacagtcatg 3719281 acgctgtgcc gttttttatg attcacttta attttgactg tacggagtcc ggcatatctt 3719341 caaacttgac ttcttcccaa gtctcgacat actttccttt cgccttcacc ttcaaatacg 3719401 cgttcttccg aagctctttg ccggcgaaaa aggtcacttc ttcttttttc ccggatgcat 3719461 tatatccgtc taatgtatat tcagtaccgc ccggactaag atgtctgcca tctcgatcaa 3719521 tctgaacata gacatcttgc tggtgaataa acggattaaa tctgtctgta acatcgttat 3719581 gaaaaaagag aagcccgcat attacggcag cagccgccaa gacggccagg attgccattg 3719641 cttttttcat ctttgcactc cccttacttg ttcatttttt tcaaatagct tgaccgcacc 3719701 gcgaggaaga atagaagctg aaaaatgaaa aaccctccga tggtgagact gagcggcccc 3719761 gctacatcgg aatatccttc cacagccaat gttctcaagg caaacagtgt atgcatgacg 3719821 gcaatgacaa atggaaagaa gaaaagaatc gccaattgta ttgtcacgct ttgcgccatt 3719881 tctcgctcac tcaggccgat tttggccagt gaacggtagc gctcccggtc ttcatctaaa 3719941 tcagtgaaca gcctgaaata taagaaactt gctgccgcga caaagaatac aattgcgata 3720001 aacaggccga taaatagact caggctcggc agctgcaccg tatcatagta agtccccgct 3720061 tttgaagcaa aatcagaatg cacgtcgata taattgccgt aaatctcatt ttgcaaggat 3720121 tggctgatct caagactgtc tttccaatga tcatagctgt agccgtataa tgacgcttta 3720181 tcaccgagtg atttcagctg atcaaaggtt tgatcattca ccgcgatgat agcattcaat 3720241 gagatcagcg gttttttgac ttcttttacc gacagttttt gatcagacag ctcccctttt 3720301 tggttcagca gcttcagctg atccggcgct tcgtttttga aattgcggtc atacgttccc 3720361 gggaaataga cagcctcgtc ttctttcagg ccgttcactt tgacatggaa gtattttgcc 3720421 gcatccgatt cactgatcat gtaaacaggg ggaacagttt ctccttcctg atagcgaaca 3720481 taggaaacat ctattttgtc tttcgtatac gtaaaaccgt gtgttttcag ttcatggtca 3720541 atatctttca aatgagtctg ttcttttgga ttgttgctgt aagataaata ctccatttca 3720601 taagcggact cttccgctcc gacggtcgat ttgtacattg cgagcacgcc tgtcgcagta 3720661 aacgcaaccg cggaaataat gctgacaata aagaacaggc gggcgttgtc ttttagacga 3720721 tagacaaggt cagaaaccca aatgatgttt ttcccgcgca gataaaaggt tttccacttc 3720781 ttcagcgcgc gcagaatcca tatgctgctt tggctgaaaa agaaatatgt tccgataacg 3720841 gtgagcagta aaatgataaa cggttcggcc ccgtggacat tgcctttaag aaccatgccg 3720901 tacccgccgc acagacaggc gatgccgaat aaggacagaa gcacggacgg cttaggctcc 3720961 ggtttaacct tgccagtgcc ctttattaat ttgataaccg tatttgatct gacaaaaagg 3721021 atcgtaaact gcgataaaaa gaaaaataag agcagaaatc cgcaggccgt aataccgagc 3721081 gctttccaag gcatatacaa aggcagcgcg tccatttcta aaatataagc gccgaccgta 3721141 aagaacgtct ttgaaaaaat gaatcctccg ataataccgg ctgcaattga catgacgccg 3721201 atgatcatat tttccgcagt aatgagcttt ctcagctgcc ccggcgtgat gccctgcatg 3721261 agcagaatgc cgaattcttt atttctcgat ttcaaaaatg cattaaccga atacagaaca 3721321 aataagaaag aaaaaacaaa gatcatccat tccgcggcgg ttaagccttt tttggcgatg 3721381 ttattcaggt agccttcctt taatgccgga tgaaacagga acatcgcaaa ggtaaagaaa 3721441 atcaaaacgg aaaaggcgct gcttaaaaag aatgcaagat aggccctttt gtttctcgtg 3721501 acgtttttat aagcgaactg aagaaaggtc atttgcgttt ccccccagca tagacagcac 3721561 atcgagaatt tgttcataaa atacttggcg gttttccccg cggtaaatct cattaaacag 3721621 ttcgccgtct tttataaaga tgacgcggcg gcagtagctt gccgaaaccg gatcgtgggt 3721681 caccatcaaa gccgtgacat gatcatcccg attcaggctc tgcaacgttt ccatgacgtc 3721741 ttttgtcgct ttggaatcaa ggtttccagt tggttcatcg gccagaatga gtgacggctt 3721801 atgaatgacc gctcttgcga tggcggcccg ctggcgctgg cctccggata cttcaaacgt 3721861 ccgcttgtta agcaggtttt cgataccgag ctttgccgcg atgccgtgca gtttttcttc 3721921 cattacagac ggcgcttctt tttcaagcgt taacggcagc atgatatttt caccgatcgt 3721981 cagcgtatcc agaaggttga aatcctgaaa cacaaatccg agctgcttgc ggcggaaatg 3722041 agcgagcttt gtccgcttca ggcgatgcgg gttttctccg ttaatcagga tatcgcctga 3722101 atctggacgg tcaatcgttg aaatgatatt caaaagcgtt gtttttccgg acccggacgg 3722161 ccccatcacc gccgtgaact cgccttcttc tattgaaaat gaaatttgct ttaaggcctg 3722221 ataggacact tgtcctttat aggttttatt tatatgtttg acttcaagca tattcgccat 3722281 gaaaatcctc cttatggttt tattcttgtt gatctgggct gctttcatgt agtgccggga 3722341 cgttcaacat aaaaatcccc ttgacataaa tccatgttat caaggggaaa caaagcgggc 3722401 tatgttgttt tcttaacgca gccttacatt tttgtaagaa atgaaaatcg aactgatgtc 3722461 ccttcaccgg gagacgagct gatgtccacc gtatgattga gcttatctgt aatttctttg 3722521 acgagatgga ggccgattcc cgtagattct tggaaacgcc gcccgttttc acccgtgtaa 3722581 taagggtcaa acacccgctt gatgtcttgt gagggaatcc cgacaccgta atctttgact 3722641 tcaagcaccg tcctgtcttc atcgcagaag acattcagct caagtctgtc actcttgccc 3722701 gctgaatact tgaccgcatt tgtgaccact tggccaatcg caaatttgag ccatttggca 3722761 tcggtgtaaa tctgatgatc atcgcaaacg ttcattttcg gataaacgcg atattgaata 3722821 aaaaatcgtt tatagctttg aataactgat tggagaagct cggacaggga aaccgcttcg 3722881 attttaaaat cccgttcaaa caggtcgagc cttgaagaat aaagaagcgt ctccagcccg 3722941 aattcaatct gccggacttc ttttttgatt tgttcaaaaa cgggctcatc ctcttcttga 3723001 atgattaaat taatgaccga cagcggcgtc tttacttggt gcacccattg attcatatac 3723061 gtcacccgcg cgtcaagctt ggcttcggtc tcatggagct tctggtgctg cagccggatc 3723121 agctccatct gcttttcata cagctctgaa cagaacactg aagaaccgag atacgggata 3723181 tccgtccctt cctgccccga gctgagccaa tgatacacgc cgcggtcttt gtaccagcga 3723241 taggcaagat agcccgccaa aataagaagc tgcacgccca atatgtaaaa caagtgagaa 3723301 aaagaatgaa gacccgcaaa ccagtaataa aagaagacaa acagcccttg aaggagaaaa 3723361 agcagaatca gcactgcatg agaccggaga aacagcttca tgactgcgcc ctcagctggt 3723421 agccttcgcc ccgcaccgct tcaatagaaa caggcgcatt cagctcccgc agtttttttc 3723481 tgagccgcgt gatatacacg ttaagtgtat tatcatcgat gaatatgtcg gtgtcccacg 3723541 tcttttccat gagacggtcc cgactcgtca ccttttctcc ccgctcaagc agcacttcca 3723601 aaagcttgct ttctttttta gaaagctcac ttttttcatc ctgaaaacgc agttcaaacc 3723661 gttccacaaa gagctgaacg ccggcatatt caaccacttt ctctccctgc tttgcggcgt 3723721 actccccgta cgccctccgg atctggcttt tgattttcgc aagcacaata tcataagaaa 3723781 acggtttttc gatataatcg tctcccccat tttcaatcgc catcacctga tccatttccc 3723841 cgcttctggc agaaataaag atgatcgggc ttgtggagtg ctggcggatc tgccggcacc 3723901 aataatatcc gtcatatgcc ggcaaattga tatcaagcag caccacatcg ggcttttccc 3723961 gcaaaaagac atcaagaaca gctgtaaaat ccgcggcgac cactgtttga tatccgtatt 3724021 tttcaaggta attctgcaat agtccgcgaa tgtcttcact gtcttccaca atcatgattt 3724081 tattcaaact gaaccactcc cgtttcttac actgctgcca tcatcataat cgttttgggc 3724141 gtatggacgc aacaccgcac aaaaaaaccg ccatctcggc ggtttctggt ctctttagcc 3724201 gacctgctgc ttagctgctt taccggctga tccgaactct ctcattttgc ttcgcactgt 3724261 ctcttccacg gcttcaatgc cgggtgtcaa atagccgcgc ggttcgtaca gatcgctgtt 3724321 ttcctgaaac atgcggcgtg tttcgtctgt ccacgctacc atacattccg tattgatatt 3724381 gatcttcgcg tggccgagcg tgatggcttt tttgatctga tcctgcggaa tcccggatgc 3724441 cccgtgaaga acgaggggaa tatcagtcat gcgggagata gcctccattt ccttaaatcc 3724501 gagattcggc tcaccctgat atttgccgtg tacagagccg agggcggcgg ccagcgcgtc 3724561 gatattggtt tctttaacga tccgctcaca ttccgtgata tccgcatagc ggaccccgcc 3724621 gaccagtccg tcttccattc cgccgaccgt gccgacttcg gcttctactg acacgccgtg 3724681 ttttgcggca taatcggtga cttcttttgt catcgcgata ttctcgtcaa tcggctgatg 3724741 ggagccgtca atcatcactg agctgaatcc ggcatcaatg gcctgtctgc agcgttccgc 3724801 actgctgccg tgatcgagat gaagcacgac cggaacggta atcgccatgt cctctattaa 3724861 cgcgccgacc atggcggcaa tcgttttaaa tccgcctaaa tagtcgacca ggcgatcgga 3724921 agccgcggcg atgaccggtg attgctcctt ttgcgccgcc tgcaaaatcg ccttcgtcca 3724981 ttgcaggccg ttgatattaa actggccaat tgcatattgc tcccgctttg catcttcaag 3725041 aagctctttc atcgatacaa aagccatatt cacccctcct ttatccatta catgctgaag 3725101 tattttgata cgacatccac tgttgttttt ttcgctgttt gaatggcttc ctcagcagtc 3725161 agcttatagt attcaggccg gaagagctca accgaaacaa catcagagaa gccgatttcc 3725221 ttcagtgctg ataagtgggc atctaagtca attgcccctt gtcccggcca tacacgatcc 3725281 tcatctgtta aaaagccgat tgggaaatct tctgtatcat caatatgata gatgaagatt 3725341 ttctttccgt ccgcctgctt taagctctca atatttgaac ccattgcatg gaagtgaaaa 3725401 ctgtcaagga caagcccgac attgtcacgg ttaactgtgt ttacaatctc atacgcctgt 3725461 tcaaacgtat tgaccgtaca ttgcggatgg ccgacaaact caagcgcgat ttttacgccg 3725521 tacggctccg cgatatctga cagctcagtc agcacgtcta cactgctctt tttgatctct 3725581 tcttttacaa tcttctgctc tgtcacaagc ggaacggcca ccacatattt cacaccgagg 3725641 gttttgcatg tttccatcat gcctttaaat tcagtgatga tctcgttgtg acccttttca 3725701 tcacggttgt tgaagaaaac gagtgcgttt aaggcaagcg gtttgatgtg gtgggtttga 3725761 aaatattccg caaggtcatc caatgaatga tcttttaagt actccggcag cttatccata 3725821 gtacggattt caatataatc atagccatgc ttttcgcata gttctaaatc cagtttaagg 3725881 tttgagtttt ccaatgttgt cgcttcatta aaacaaagtt tcatgccaga ctcccccatc 3725941 tgcgttttag atatgaaggg agttcggcag gaaggctgtc gccatatccc gccgaactcc 3726001 atgctcagct tatgccagac ctaattcttc tttcattttc ttaagcataa atcggcttga 3726061 ttcatccgct ctttcatcga cccaagcaaa tacggcattc gtcgcaattc cgtcgaactt 3726121 catctctctc agttttctga aaatcgtatc aaaatcaacc tcgccttggc caatgtccaa 3726181 atgctggtga accgttactt tcgcgtcagg cggattgacg atgtagcgaa ggccatgagc 3726241 cgctttatga ttataggtat ctgcaaataa aacatgtgtg aggcggtcgc cggcttcgtc 3726301 aaacatggtc tcgatgtcgc ctttgccgtc atcatagaag aacgtatgcg cagtcgagta 3726361 gacaagattg atccaatcct tgtcaagcgc gcggatcata tccatcgcac ctttgtgcgt 3726421 ttcgataaaa tcatatggat gggcttgaag attgagttta atgccttctt tttcaaagac 3726481 tggcagaagc tcatccatgg atttgataaa tttttcttca cttgttaaag gatcatattt 3726541 tgaaccgctg aattcgctgt tcatcaaatc cacttcaagt tcaaccgcaa tttcgattgc 3726601 ccgtttccag ttgcgcactg ctgcctggcg gcggtcttca tcgggtcccg cccagtggta 3726661 aagaggaaga agcgatgaaa gcttaacacc tgtatctctt aaaaggcgct ttaattgttt 3726721 gatctttgct gaatcgactt tcggatattt ataaaacggg caaaaatcct cgcgcggcga 3726781 taattcgata tattcatagc cgagctctgc cgttttatag accatttcct ctaaagttaa 3726841 atcatcacga tacatggatg gatccaatgc taacttcata ttttcactcc tctgtttttt 3726901 agttttgaac tgttgtaaaa gattgataga attccggttt ttccttcaat tcaacctttt 3726961 ctttttgtcc agattcctgg gcttttacac acgcgtcagt cgtgacagca gcaatatagc 3727021 cgtcccatgc cgtcggtccg ctgacctcgc ctttcttttg aatcgaatca ataaagtctt 3727081 ggatttccac atcatacgca gcgacaaagc gtctctgcca atccatcaaa atatcagtgc 3727141 tgaatctgcc ttcttttctc aagctgatgc ttgatggctc gggaagcttg atgatgccgt 3727201 cttctccgac gatttcacat tgaatgtcat agccgtattt acagttcaca tagatttcag 3727261 cattgatgac gataccgcct tttgtttcaa tcacgacgat ttgcggatct tttaaatgtg 3727321 gaagcgcgtt ttttgatttt ttcggataga tgacttgaac ggactcgtag tcatcattga 3727381 cgagccagtg gagcacgtca atttcatgaa caagcgtgtc gactacagcc atatccgttg 3727441 tatagttatc tcctacagtc gggttgcggt gcgcgcagtg aatcataaga ggctcgccga 3727501 tgacatgatt atcgagcgct tctttcagct gtacgtaacc gctgtcataa cggcgcatga 3727561 agccgacttg aacaaggcgt ttgcccactt tgatttcttc ttcgacaatg cgcatgcatc 3727621 cttcagccgt tgtcgcgagc ggtttttcac agaacacata tttctgggct ttaatcgctt 3727681 tcagcacgct tgactcatgc gcaggccccc agcttgtcac taaaacagcg tctacatttt 3727741 cgtctgcaag caagctgtca tcattcggat aaaccgtcgc gtttaattgg tattgctcaa 3727801 cgaccttttg tgcagcttct tgattaacat ccgttacagc tacaatttcc gcgcctgaca 3727861 gcttgttcgt gatacggtta atatgttctt ttccgattgc tccagttcca attacgccaa 3727921 tacgtaaact cattgacagc cactccttct gttggttaca tgattttgct ttctgttcct 3727981 ttctttactt ggctctgagg agacccgtag agttcctctt gaatttgttc aagcgacttg 3728041 ccagacgtat tcggcgcaaa gagcagcccg atgatcatac tggccgtcac acatccgaga 3728101 agaattgcag ccatcgttcc aatgccgaaa ttggtgataa tcattgggac aaacagactc 3728161 caaatcccta ttgaaatacg gacaaggaaa aacatcagtc cttgtgcgga agcacgatat 3728221 tgcgtaggaa agatttcgct ggcccataac tgatagttcg cttgctgccc ggctccgtta 3728281 ttgatgccga tcacgacaat aaacaggagc agaatcggca ggccttcaac tggcagcaga 3728341 aacagtgtcc acccgatcac cgccatgaaa gcggcgattc caaatacggt ttttctatat 3728401 ttgtcggcaa agggcatgaa gatcaaggcg acccccaatc ctgtgaagat aaacagcccc 3728461 atttgcaaaa ggttggccat gttggcagat acaccgccga cctgctgata aatgtatggc 3728521 ataaagaagc ccatgacccc ggcggctagg ttccaaacca agtacacacc catcaaaaac 3728581 aggatgcttt ttagatacat aggcttgagc aaatcaaaat acgatgtctt attcaataca 3728641 gccggcttct ctgcctgagc ttcctccggc tgattttttg tctgccaggc gtctgattcc 3728701 ggaagcctga ttctcaggat gtacgtaatc agcgcaatca caagcagatg ggcaaatacg 3728761 attttattcc ccaagagtcc caagtcaccg gccagtacgg agaggagcag tacaacgaca 3728821 gcgcccgcgg cccaagcgac ttgtgctacg ccgcaatgcc tggcccgatt cttctttggc 3728881 gcattttccg caataatggt ccatgacgcg gttatgtcag cccctactga taaaccgata 3728941 atgatgtaac cgcttaacaa catggggaaa ttaaccccga acaaaaccaa acaaatccct 3729001 agtgcataaa ccagcatact attggtataa acagccttcc gtccgacttt atcagccaga 3729061 aacccgccaa gcagcgcgcc gacagcggca gaaatcgcat ttgcgctcaa cgcgccgagc 3729121 agcccgattt gcgtatcgga tagcttaagg taactgaccc ataatgataa accggcggag 3729181 cctgccacaa ttgaaccggc atcaatatag ttggccaatg ctgccgcgat tgtccgttta 3729241 ttgaaggctg aatctccatt ggtattgccc atatgttcat tccccattaa gccagatcca 3729301 acaactgctg atcaatatag tttctcgcaa tcaatgcata ctccagcggg tttgcaacat 3729361 cggggtcttg ttcagcttca atgacaatcc atccggaata actgtgcttc aacagcagct 3729421 gatatacttc tctaaagtca atgcagccgt caccgggaac cgtaaacatg ccttttaaaa 3729481 atgattgccg gaacgattgt ccttcgagcc tgcattgttc catgacattc aggcgggcat 3729541 ccttaaagtg cacatgctta atgcggccga tatgcttctc aagcatcccc atgtaatcgc 3729601 cgtcagaaat atacgcatgg cctgtatcat agaggaggtg tacatgcgca gggtctgttc 3729661 ctgccatcag gcggtccact tcttccgctg tttggacacc agtgccgaga tgatgatgat 3729721 agacaagctt caagccatgc tgagcggcaa tttcgccaag gtgattcagc ccttcgcaaa 3729781 gccgctccca ttcatcatcc gtaaagtgcg gcttctctgt gaacacattt ttctccaagc 3729841 tttgcacgct gtacgtttgt tcagagacaa ctgcgacatc cgcgtttact tgctgcaaat 3729901 actcacaatg cagggtaaat gtctttgccg cttcaccaag tccgtcacgc aaaataaaac 3729961 tgctgaacca ttttcctgca atgcgtaagt tccgaagctt cagctctttg ttcaggatgg 3730021 caggttcggg gaaaaagccc ccgacctccg tgccttgaaa acgtgcgaca acgatatcac 3730081 ttaacaaatg ctgaagtgta tttcccgctc caatttcagg catgtcatca ttccgccacc 3730141 caatgggagc gattccccac aggatttcat ttttgcccat ctatggtgcc tcccctctaa 3730201 tactgcttcg cagattccag ctttttctct tttgcttcgt atgctttctg aacgctttct 3730261 tgttcagata cctctgccac cccgacatgc caccagctgt catagccgtc cgtcattgtt 3730321 ttaggcagca ccttcatttc aattaatgtt gatacatcct gtttcttcgc atcctctaac 3730381 gcagctttta attcttctac tgtgtttgca cggtaggttt tcgcgccgta tccctcagcg 3730441 actttcgcgt aatcgacatt caggatttgg ttgtcatctg tgcggaactc gcaatagtag 3730501 ctgccgctgc cgtgatccat ttgcaggttg ttgatgcatc cgaatcctga gttgtcaaag 3730561 agcagcacat tgattttctt gttgtactga atcgccgtga tcagttcaga atgaagcatc 3730621 aggaagctgc cgtctccgac gattgaatac acttctctgt cagggtgggc cagtttaaga 3730681 ccgagtgtcc cggacacttc atagcccatg caagaatatc catactccag gtgatacgta 3730741 ttcggaacat tagaatgcca cagacgctgc aaatctcctg ggagtgagcc tgctgaacag 3730801 atgatgacgc tgtcttcagg aatcgtctcg ttgattgtca gcaatgccgt tgtttgcgga 3730861 agctccgtat tcaacgcgtc agcatattca ttcaggacct cttgagaaaa gtgatttttg 3730921 atttccggat caaatgcttc ccgcttaaac gtcactttgc tgagacgctc gcgttcagct 3730981 agccattcgt ccttcagctc ccggatcgtt gtgccgaact cgctctcata gccttcaagc 3731041 aagccgtgca gtttgccaag cgtcactttc gcatccgcca ccacttggaa tgcatcaagt 3731101 ttatacgcct gcattcggct gacgttaatg ttcaaaaact tcgctttatc aaaatcaaaa 3731161 gcggtcttag aggatgtcgc aaaatctgta taccttgtgc cgatgccgat aatcaaatca 3731221 gcttggcggg ccgctttgtt tgccgcaagt gtacctgtga tgcccattcc gccaaggttg 3731281 ttcgcaaaat ctgcctcaac ggtagacttt cctgcctgcg tttcaactaa cggaatgtta 3731341 taggcttcag aaatggcaac caattcatcg cgcgcaccgg aatattttgc gcctccgccg 3731401 acgagaatca caggtttttt gctggattta atcagctccg ccgcaccttg aagctcgcgc 3731461 tcgctcggct gcatgcgatc aatatagtga acccgtttga cgaagaaact ttcatcaaaa 3731521 tcgtatgctt ccccttcaac atcctgagaa atacaaatcg ttgccggacc tgcttttgcc 3731581 ggatcagtca tgacttcaaa cgcgcgcagc aaactgctca tcagctgctc agggcgcgta 3731641 atgcggtccc agtatctcga tacaggcttc aatgcatcgt ttgtcgtaat cgccgcactg 3731701 tattcttgct ccatttgctg cagtacaggg tctggctgtc ttgtcgcaaa tgtgtctgcc 3731761 ggaatcaaga gaactgggat attatttgcc aatgcagtgc cggctgccgc caccaagtta 3731821 gccgctccag gtccgacgga tgtagacacc gcatatattt ttcttctcag catttgcttg 3731881 ctgtacgcca tggccgcatg cgccattcct tgttcatttt tcccttgata gactttcaaa 3731941 tggcctgcat cctgctcaag cgcctgcccg atccctaata cgtttccatg accgaaaatc 3732001 gtgaagatcc cttcgacaaa aggctcttcc tttccatcta catggatgta ctgctggttt 3732061 aagaatttaa tcagcgcctg cgcagttgtt aagcgaattt tcttacccac aaacgatccc 3732121 acctttactc gatctttttc aattatgact gtgcttcaat aagctgttcg atttcttccg 3732181 cagtcggcat cgcttctgac gaactgtgct tgctcaccac aatggaggct gaagcactgc 3732241 cgtatttcaa tgccgtttca atgtcttttc cgctgacaag gccatagata aaggctgacg 3732301 cataggagtc accggcccca aaggttttca gcacttttgt cttgtacgct tgagcgcgga 3732361 atacctcgcc ggatttgctg tatgcgtaag agccttcgac gccgtgtttg atgacaacga 3732421 ggtcggctga atggccaaat aaatgattga cggattcttc attgcttccg cctgtgcggt 3732481 tttccatcac atcaaattca tcgcgtgtgc cgatgacgat atcagactgc tcggcaacca 3732541 aagaataata aacggctgtt tcatctgatg actgccacgt atatggccgg taatccagtt 3732601 cgaataccac cttaacctga tgctttttcg cgtattgaac agcttttaac accgcttccc 3732661 gtgacgggct tttggcgagc gctgtcccgg agacaagcag cattttcgca tttgcgatat 3732721 agtcctcact tacctctgaa ggctcaagat aaagatccgc cacatcatcg cgatacatta 3732781 agatgctgca ttcttcaggg ctgaggattt ctgtaaatgc aaggcctgct ttgtgtccat 3732841 cttgatcaac aatcatctgt gtagtatcca cgccggtctt tctcatatag gactctatga 3732901 atcttccatg ctggtcatcc ggaattttgc cgatgaagcc cgcttttaag ccaagcttcg 3732961 cgctgccgat cgcgatattc gcaggtgaac cgccgacata tttcgaaaat gtcatcgttt 3733021 cttccattgg gcggttgtat tcgactgcgt tcagatcaat acatgcccgg ccgatggcaa 3733081 caatatcaaa agccttctct tcattgaatg tatacttcat cgtaaacagc cactcctcac 3733141 ttgttagcgt tctaaaatcc attcatgcgc cgggtcgtta taaaacttcc attttcgcgt 3733201 cggccctgcc atgacattta aatagtagga tgtgtatccg tccggaacgc ctaccgggtg 3733261 gtatcccgca ggaacgatga caacgttttc atttcccaca gtcattgtct cgtcaataga 3733321 acggtcatct gtgtatacgc gctgaaacac aaagccctgt cccgggtcta actcatggta 3733381 gtacgtttct tctaagaaag attcttccgg caagttgtct tggtcatgtt tgtgaggcgg 3733441 gtagctggac cagttgccgc tgtctgtata gacttcaact actaatagac tgttagctga 3733501 agggtctgaa tccggaagaa tgttatgaac agtacgtttg tttgaaaatt gcccgcgatg 3733561 ctcaattccg ttgtcttccg ctttgatcag ctttgtcgga agctgctttt ccgatggaga 3733621 atagcaaagc gccactcttg cgtcgctgac cgctgtgatc tcaaatgcac ggtcatttga 3733681 aatatagacg ctgtctgtcg gttttcgttc aaatacgctt tcgcgcgtgc cgatattctc 3733741 aaaagtcgac tcatgatctg tcactgtaat tttccccgtt accgccacaa tacagatttc 3733801 ttgttttttc aattcttctg tatagcttga acctgatgca agatctaaca ctttaaactc 3733861 tacataagtg agatcagagt tggatgtcgt tacttcgtgc acgagtttga ccccattaga 3733921 cacttcatgc gactgcggct tacgcaacaa ataactcata gagaagccct cctctttcta 3733981 ttggcagaat gagtccgaac agcgcacatg gacgccgttc ggctgttcgt cgtttagttg 3734041 aaatcaggtg ccggatatct tgccgtcacc acttttttac gtgtatagaa gtcgacgctg 3734101 tcttttccgt tcgcatgcag cgttccaaag aatgaagatt tccagcctga gaatgggaag 3734161 aacgccattg gagccggcac accaaggttg atgcctagca ttcccgcatc aatgttttca 3734221 cggaagtagc ggattgcgtt tgagttggat gtgaacaagc aggcgccgtt cgcaaactca 3734281 gacttattgg cgatttcaat cgcttctttc aggtttttca cacggatgac agataagacc 3734341 ggagcgaaaa tttcatcttt ccagatcgtc atttctgttg tgacattgtc aaagatcgtc 3734401 gggccgacaa agtagccgtc gtcagacaca ttttcacgtc cgtcacatac gagtctggca 3734461 ccttcttcaa gacctttttc gatatagctg agcgtgcgct tcttgttgtc ttcgcgaatc 3734521 accggtccta agaacacgcc gtcatcaagg ccgttaccga ttttaatgtc cgccactttt 3734581 tcctgcagct tcgccataaa ttcatcggcg attccttctt caactgtcac aaccgcacaa 3734641 gccatgcagc gttcaccggc agaaccgaag gcagctccaa cgatgtttgt aaccgtgtct 3734701 tcaagattcg catcgttcaa gacaatcgta tggtttttcg cgccagtcag agattgaacg 3734761 cgttttaagt tttcgcttcc ttttttgtag acgtattcgc ctactggctt ggagcctaca 3734821 aatgaaatcg ctttaatttc gggatgctcg aggatgccgt tcacaacgtc atgcgcaccg 3734881 tatacgacgt tgaacacccc tttcggaagg cccgcttttt caaaaagctc aaccaatttc 3734941 tctgttaaca gcggagtccg ctcagatggc tttaaaataa atgtgttgcc gagcgcgatc 3735001 gccatcggga acatccagca aggaaccatc atcgggaagt tgaatggcgc gattccgccg 3735061 acaactccga ttgggtaacg gtagttcgcc gcttcaacgt ccgttgcgat ggaagcaagt 3735121 gagtcaccca tcatcaggga aggtgctcca gcggcgaact ctacgttttc aatcccgcgt 3735181 cccacttcac ctaaagcttc tttcgtgttt tttccgtttt caatggtaat tagatgagca 3735241 agttcttctt tatgctgaga cagcagctgc tggaagttaa atagaattct ggcgcggcga 3735301 ggaaccgcca cctttgacca tgttttaaat gcttcagccg ctgtttgcgc tgcgtaatca 3735361 atatcctctt ttgtagaaat cggcacttgg catagcactt ctttcgtcgc cggattgacg 3735421 acatcttcat attgatctgt tttgctttca acccattcac cgttgatgta gttttttaat 3735481 tttctgattt ctgccattct tattgcctcc ttcattagta aacacataca cttgtatgga 3735541 tggttccgga tagattcata tcaatatcca cttttcagca agccaagaat taaacgcttt 3735601 caaaaacacc aaaaaaataa atggcggatg catatttaca tacaagcaac catttcatgc 3735661 acaacaggtt actttttggt catttcttgg ttatattcta atcgcataat acccataagt 3735721 caatcataaa cactacattt tttcattatt tttattatat taatctttta atcaagtaag 3735781 agaagtaaga gaaggccgtc caatcttgca aaagatatac accgatgtta tcatttttaa 3735841 gcaactattg attaactttt ggtttttatt atatatttat gttacgtaaa gattcaagaa 3735901 ggagtttttt atatgaaact gatgcggatt caggaaatgg aggagtacat tttatcgcat 3735961 ggcactgttt ccttagatga gctgtgccag gtgttcaatg tctccaaaaa cacagtcaga 3736021 cgtgatatca acaagctaac agaaaagggt gcgattgaaa aagtatacgg cggcgtaaca 3736081 tctattgaaa aaaccgcatt agttcctttt gaaaatcgca ccattcagca ccaggatgaa 3736141 aaaacaaaaa tcgcccatta tgcttcccga tttattgaag atcacgattt ggtcttcatt 3736201 gattcaggaa cgacgacaaa gtctattctt gatacgcttg atccagccaa aaatgtcacc 3736261 atcttaacca acagtttaga cattatcaat gcggcgtcag ctttgaagaa tatcaactta 3736321 atcattatcg gaaacaacta taagagaaaa acccgctcct ttgtcggcat ggacgacccg 3736381 gctatgcttg ataagtacaa tatcaacaaa gcctttatgt ccgctaccgg aacgacgctg 3736441 actcacggat tgaccaattc ggatctgctg gagtatgaaa ttaaaaagag gatttcagaa 3736501 aaagcaaaag aagtgtatct attggctgac cattctaaat tcggaaaatc aacgcttctg 3736561 acgtatgcac cgtttgacag gctgcattgc attgtgacct ctcagccatt agacgacgag 3736621 tacacgcagt actgcaatga gcatcaaatc ggcattcatc tggcctaacg tttacaatag 3736681 tgttgagagt ctatcatcca ttttattcta ggaggcagat catgaaaaaa gcgaagctcg 3736741 gaaaatcaga cttgcaggta ttccctatcg gattaggaac aaatgctgtc ggaggacata 3736801 acctctaccc gaacctaaat gaagaaaccg gaaaagaatt ggtgcgcgag gcgatccgta 3736861 atggcgtgac aatgttagac accgcttaca tttacgggat cggccgttcc gaagaattaa 3736921 ttggtgaagt gctgcgtgaa ttcaaccgtg aagatgttgt catcgcgaca aaagccgctc 3736981 acagaaaaca aggcaatgac tttgtctttg ataattcacc agattttctt aaaaaatcag 3737041 ttgatgaaag cctgaagcgc ttgaataccg attatattga tttgttctac attcacttcc 3737101 ctgacgaaca tacgcctaag gatgaagccg ttaacgcgct gaatgagatg aagaaagccg 3737161 gaaaaatccg ttccatcggt gtatccaact tctctttaga gcaattgaaa gaagcaaaca 3737221 aagacggttt ggtagatgta ttgcaaggcg aatacaacct gttaaaccgt gaagcggaaa 3737281 aaacattctt cccgtatacg aaggagcata atatttcatt tatcccttac ttccctctcg 3737341 tatcaggttt attggcagga aagtatacag aagatacaac gttcccagaa ggcgacctgc 3737401 gaaacgaaca ggaacacttc aagggtgagc gtttcaaaga aaatatcaga aaggtcaaca 3737461 agcttgcgcc gattgccgaa aaacacaacg tggatatccc tcacatcgta ttggcctggt 3737521 atttagcaag accggaaatt gatattttaa tcccaggagc aaaacgtgcc gatcagctga 3737581 ttgataacat caaaacagct gacgtgacgc tttctcaaga ggatatttca tttattgata 3737641 agctgttcgc ataagaagaa aacagccttc tccaatggag aaggctgttt ttttgtgcga 3737701 taaattccta aataactgat tttgaagcaa aaccttacaa aatgagccat aaatccgata 3737761 aaataaaggt agtttatctc agaaagaaag tgattgagaa agcaaaagta tgaaacgttc 3737821 atatcatcta gctcatatga aataaagctg acccagcttc ttttatttgc tggtcagaat 3737881 agcggaccgt ttcgatggtc tatggaggaa acagaatgaa acttaaatat gtaaaagcct 3737941 tagttgcagt aaccgttgct ttaggtgtac tgctgccatc aacgatttct catgcaaaga 3738001 gctttagcgg ccgctcatca tctagttaca gcagccgaag ttcaagctca tcatacagcg 3738061 gaagctataa atcaagcccg aaatcaagct acagctcagg atcaagctct tctagcaaaa 3738121 aatccaagac gtctgacgat tcatcatcat cgatttcgct taaaaagaag ccttcggaaa 3738181 aggcaagttc atcaagctct aaaaaatcgt caggcacctt ttccggcgct acatcaaaag 3738241 taaccggaaa gacatacagc ggaaaaacgt ctaaagccta tgttggcgga cgttatgttt 3738301 cagtcaatca ttactatcac gcaggtttcg cgccatcagg atggtttgga tattatagcg 3738361 gatttacaat gggtatgttc atgatcagca tgatgcaccc atggggttac acctatcatc 3738421 cagtcggagg ccccggttat gtttcttatg gcgcttcacc cattgcctgg atcgttgata 3738481 tcatcgcttt gattattatt ttaatcattg tcatcgcatt gattcgcgca tttaaagcac 3738541 cgaagacgta cagaaggaga ttttaggcaa tgagattaat attaaatgag caagaaattg 3738601 tagacggaat ttgcgtgtat atttccaatg aagaagatat ctaccctgaa gacgttgaag 3738661 taaaagaact atcgtacaac aagcgtacag ggttcttcgc tgaagctaca tttggcctgc 3738721 accacaagca gcttatgtca gatgacattt cagaaggcat tattcagttc ttagaggaat 3738781 accacaactt caatccggac gttaccgtcg ttgaattgca atttgataag aaaaaaggct 3738841 tctccgcctt ggtttttgtc aacgaagcag aagaataaaa atgtcttaat caaaccttac 3738901 tccgcgcggg taaggttttt ttaatggttt ctctgagcat aaagttattt cgtttttcct 3738961 aaactcagcg gatctgtgat catctctttt ggctataaag tttccgtttt ttcaaaacaa 3739021 atgtttcaaa tgagatagga aatgggtact aatctattaa ctttgttaca tatttttaga 3739081 tactcattgg ctcaacaact gaggaggaga catttgtgaa gaaagacaca aggaaatata 3739141 tgatctactt tttcggcgct ttagggggac tgctatatgg ttacgataca ggtgttatct 3739201 ccggagcact cctgtttatc aataacgata ttcctttaac gacattgaca gaaggattgg 3739261 ttgtcagcat gctgctcctt ggcgcgattt tcggttctgc cttgagcggc acatgctcag 3739321 accgctgggg caggagaaag gttgtatttg tcctttccat catttttatt atcggtgcgc 3739381 tcgcttgcgc attttctcaa acaatcggca tgctgattgc atctagggtg atactcgggt 3739441 tggccgtcgg cggttcaacg gcacttgtgc ccgtgtatct ttccgaaatg gcaccgacga 3739501 aaattcgcgg gacactcggc acaatgaaca acttaatgat tgtcaccggg attttgctcg 3739561 cctatatcgt taactacctg ttcacaccgt ttgaagcgtg gcgctggatg gtcggtctgg 3739621 ctgcagtgcc tgccgtgctt ctattaatcg gcatcgcctt catgccggaa tcgccaagat 3739681 ggctcgtgaa gcgcggcagc gaagaagaag cgagacgcat catgaacatc actcatgacc 3739741 ccaaagacat cgaaatggaa ttggcagaga tgaagcaagg ggaagcggag aaaaaagaaa 3739801 cgacacttgg cgtgctgaaa gccaagtgga ttcgccctat gcttctgatt ggcgtcggcc 3739861 ttgccatttt ccagcaggca gtcggcatta acacggtcat ctactacgcg ccaaccattt 3739921 ttacgaaggc cggtcttggc acatcagctt cggcgctcgg cacaatggga atcggcatcc 3739981 tcaacgtcat catgtgtatc actgccatga tcttaattga ccgtgtcggc cgcaaaaaac 3740041 ttctgatctg gggaagtgtc ggcatcacac tgagccttgc tgctttatca ggcgtgctcc 3740101 tgacactggg gctttccgca tcaacagcgt ggatgacagt agtctttctc ggtgtctata 3740161 tcgtctttta ccaggcgaca tggggtccgg tagtgtgggt gctcatgcct gagctcttcc 3740221 cgtccaaagc acgcggagcc gcgacagggt tcacgacttt ggtgttatcg gcggctaacc 3740281 tgatcgtgtc gcttgtcttc ccgctgatgc taagcgcgat gggcatcgca tgggtcttta 3740341 tggttttctc agtcatttgt cttctctcat ttttcttcgc gttctacatg gtaccggaaa 3740401 ccaaagggaa aagcttggag gaaattgaag caagcctgaa aaaacggttt aaaaagaaga 3740461 aaagcaccca aaaccaagtg ctgaatgagc gtacattata aaaaaaggaa tcgtctcctt 3740521 atgagacgat tcctttttct gtttacacca tgaccttgca aatattgttc gtaaattcca 3740581 cagggtcctg aatcggcagg ccttcgatga ggagcgcctg attgtacaga aggtttgtgt 3740641 acaggctcag cttctcttta tcttgttcaa acgcgtcctg cagtgtttgg aatacctcgt 3740701 gatttgggtt gatttccagc actttttccg ccttcacatt ttggctgtca ggcatcgcat 3740761 ttaagatttt ttccatctca attgtcactt cgccgtcagc agcaaggcag actggatgtg 3740821 atttaagccg ttttgagatt ctgacgtttt tcactttgtc tgacagaatg tttttcattt 3740881 cctcaaacag atccttatac ttgctttcct cttcctcgga ctgcttttga tcctcatccg 3740941 tgtctatgcc aaggtctccg cttgatacgg acttgaattc tttttcctga taagaagcca 3741001 gcattttaat tgcaaactca tcgatgtcct cagtaaagta gaggatttca tagcctttgt 3741061 ccgccaccat ttccgtttgc ggcagtttct caatgcggtc gtaagaatca ccggtcgcgt 3741121 aataaatgaa tttctgctcc tctggcattc tggaaacata ctcgtctaag ctgaccagtt 3741181 ttttctcttt tgaagagtag aataagagga gatccttcaa ttgatcctta ttcgcgccaa 3741241 aatcattgta cacgccgaat ttcagctgtc tgccgaacga cttgtagaac gtctcgtatt 3741301 tctcgcggtc ttttttcaac aggctttgca gctcgctttt gattttcttg ctgatgtttt 3741361 tcgcgatcag cttcagctgg cggtcatgct gcagcatttc tctggaaata ttcagcgaca 3741421 gatcctcaga atcgaccatg cccttcacaa agctgaagtg gtccggtagc aggtctgcgc 3741481 acttattcat gatcagcacg ccattggaat acagctccaa gcctttctca tattccttgg 3741541 aatagtagtc aaacggcatg ttttcaggga cgaatagaat cgcgttgtag cgaaccgctc 3741601 catccacgct gatatgaacg tgtgtcagcg gtttatcaaa cccgtaatgc ttttcagcat 3741661 agaatttttc ataatcctca tctgtcagct cgcttttgtt ttttctccag atcggcacca 3741721 tgctgttgac cgtctgctct tcctgcacct cttcaaattc attttcgctg ccttccttcg 3741781 gcttattaat ggttgtatcc attttgatcg ggtagcgaat gaagtcggag tacttcttga 3741841 tgatcgcttt taaacgatat tcctctaaaa actcgtcata gctgtcatct tctgtgttct 3741901 ctttgatttt caggataatg tctgtaccga cagaatcctt ttcacacggc tcaatcgtat 3741961 agccgtctgc acccgcagac tcccatttat aagcctcttc gctgccaagc gctttactga 3742021 tgactgtcac gacatcggca accataaatg ccgcgtaaaa accgacaccg aactgcccga 3742081 taatgtcatg tccgtctttc agctcgtttt cctttttaaa cgcgagggaa ccgctttttg 3742141 caattgttcc aagatgctgt tcaagctcat cctttgtcat tccgatcccc gtatcagaga 3742201 tggttaatgt tctcgcatct ttgtcagctg cgacctttat gtagtaactg tctttatcaa 3742261 acgtaagcgc atcgtccgta agcgctttgt aatagatttt gtcaatcgca tcactcgaat 3742321 tggagattaa ctcgcgcagg aaaatttctt tttgggtata aatggagtta atcatcatat 3742381 ccagcaagcg tttagactct gctttaaact cttttttcgc cactcttgat cgctccttta 3742441 ccattatgta aacccttttc agcatctatt tatcacataa gatgacaatt gtcaattaga 3742501 ttgatagatg catatatatg taaatttaac attagttgga tttgttttca ctctttttct 3742561 cactcattct cataaaaaag agaggcttca tcatcctctc tttttttctg tgtcattcca 3742621 acggccaaac tcccgcttca tccatatatg caccgggtag aaaaacaaac cgaacggtat 3742681 caaaaacaaa agattatgcc atgaagcatt cagaaatgcg cttgcagtca ccgggaacgt 3742741 aatctcttgc aataaaaaag agatgacagt cagcacaaca aatgcagatg gaatggtcac 3742801 gatgcaataa aacttgagct ccttcttatg ctgtaccttc aaacatacaa acctcccaac 3742861 aatttctaat tcatcttaac atatgctggc ctttcttttc tcgcatgttt atcactgcac 3742921 atagcgggaa gacaaataga aaaaggaggt ctcgtatcat gggaagactt gaaaacaaaa 3742981 cagcagttat cacaggcgcc gcgacaggca ttggtcaagc gacggcggag gtttttgcca 3743041 atgaaggcgc gcgtgtgatc atcggagata tcaataaaga tcaaatggaa gaaacagttg 3743101 acgcaatcag aaaaaacgga ggacaggccg aatcctttca cctcgatgtg tcagatgaaa 3743161 acagtgtgaa agcatttgct gatcaaatca aggatgcatg cggaacgatt gatattctgt 3743221 ttaataatgc cggcgttgat caggaaggcg gaaaggtgca cgaatatccg gttgacctgt 3743281 ttgaccgcat tatcgccgtc gacctgcgcg gcacattcct ttgcagcaaa tatttgattc 3743341 cgctcatgct cgaaaatgga ggctccatca tcaacacctc ctccatgtca ggccgtgccg 3743401 cggaccttga ccgctccggc tacaacgccg caaaaggcgg tatcaccaac ctgacaaagg 3743461 caatggcaat cgactacgca cgaaacggca tccgcgtcaa ttccatttca ccgggcacga 3743521 tcgaaacacc gctgattgac aaattagcag gcacaaaaga acaggaaatg ggcgaacaat 3743581 tccgcgaagc caacaaatgg atcacgccgc tcggacgtct tggccagccc aaagaaatgg 3743641 caacagtggc actgttcctc gcatcagacg acagctcata cgtcacagga gaagacatca 3743701 ccgcagacgg cggcatcatg gcgtacacat ggcctgggaa gatgctgatt gaggagaaat 3743761 ggaaggaaga aacgaaataa gagagggagc cccctctctt tttgtctttt aaagcaatac 3743821 aaccttatat ttcttcacat ccaaaaactg caaaaactcc ctcgccagca cttcaggcgg 3743881 atgcgccttt ccttcatcca gccgatacaa aagcaacccg ataatcattg cggatacata 3743941 atgggcataa agctttttct ctgcgtgaat atcagtttgc tgatgcagat aaaacgattc 3744001 cagcgctttg aacatatcag gtatcacatg aggaacaccc cattcccgat tgagaaaatg 3744061 gacaatgggc atgtttgaca aagcagaaag cagaatggcg agcgccttct ccgcttcctt 3744121 taaggaaaat tcattcgggc tggaggcaat cgtcaggtga tcaatgatct ccgcacatga 3744181 tcgctgtatc atggtttgga gcaattcctc cttattggca tagtgatcat aaaaggttgc 3744241 acggcggata ttgcttttac gcgtaatatc tgaaatcgtg atgcccgcgt agtcttgttt 3744301 ctccgccaat acatccagaa atgccttctg cagcgcctct ctcgttcgaa ccacccgcct 3744361 gtcgatttgc ttctccttct ctcgctctcc tggcacagct tttccaaaca gccaataaaa 3744421 ccgcttttga gaaacaagct cccatacctt ctggctgatg gcttcaggag acgcggccgc 3744481 atcctcattc agccaataca ggataatcgc gtacgtgtac aaggcccgat aatgtccata 3744541 aatgtcccgt tcaatcggcg ttaaattcac atggatcgga gccagcagca catcctgctg 3744601 aaacacatcc ttaaaaaaac gatgaaaatg tcctctgttc atcatcacag aaaaaaagga 3744661 acgatgctca tgaacaaagg acagcgtcgg atgcaccgtt tgccgttttt tgttcaaatg 3744721 aagggtatcc atatgactga aggcgtcaaa aagcgctttg cccagtcctt ccttcatgtc 3744781 ttcgatcaca tcctcaatga ttgaaaactt atcctcataa taaaggtaga gcgatccgcg 3744841 gctcactttg gccttctcag cgatttcttt cattgtgatg tgttgaatat ctctatcttt 3744901 caataaagcc agcagcgcct ctttcacttg agcttcggca gattccggca caaaagacac 3744961 ctccaatcat tagacagatc ttagatatat gtacggtaac gtatagatgg ttcaccgttg 3745021 tctttcttac agaaaaggta ccaccttata ataggtccga gaaaagaaga aagcaaatga 3745081 gggggatttt acaatggaac agcaagtaaa ggacgacatc cagcgtgtct ttcagcttca 3745141 gaaaaaacag caaaaagcct tgcgcgcttc aacagcggaa cagcggagag aaaagcttca 3745201 acgcttttta gattccgtca tcgcccatga agaagaaatc atcgaagcga tccgcaaaga 3745261 cgtccgcaaa ccatatcacg aagtcaaaaa agcggaaatc gaaggaacaa aaaaagcgat 3745321 tagagataat atgaataacc tggaacaatg gatggcgcct aaagaagtcg gttcatcgtt 3745381 aagccctgac gcaaacggaa ttcttatgta cgagcctaaa ggcgtcacac tcatcctcgg 3745441 cccgtggaac tatccgttta tgctgacgat ggcgccgctt gccgcttctc tcgcagccgg 3745501 aaacagcgcg attgtgaagc tgtccgattt cacgatgaac acgagcaaca ttgctgctaa 3745561 agtaataaga gacgcttttg atgaaaaaga agtcgcgatt tttgaaggag aggttgaggt 3745621 ggcaaccgaa ctacttgatc agccgttcga ccatattttc ttcactggaa gcacaaatgt 3745681 cgggaaaatt gtcatgacag cggctgccaa acacttggca tctgtcacac ttgagcttgg 3745741 cggcaagagc ccgacgatca ttgacagtga atacgatctg atggacgcag cgaaaaagat 3745801 cgccgtcggg aaattcgtaa acgccggcca aacctgcatc gcacctgatt acctgttcat 3745861 taaaaaagac gttcaggaca ggttcgcggg gattttacaa acagtcgtca acgctggatt 3745921 tatggaggat gatcataccc cagaccgcag caaatttacg cagatcgtca atgaccgcaa 3745981 cttcaaccgc gtcaaagatc tgttcgacga tgccatcgaa agaggggcgg aagtggtgtt 3746041 cggcggcgta ttcgatgcca gcgaccgcac gatctcgcca accgttttga aaaacgtcac 3746101 gcctgacatg aaaatcatgc aggaggaaat cttcgcatcg atcctgccaa tgatgaacta 3746161 tgaagacatc gacgaggtca tcgattacgt aaatgaccgc gataaaccgc ttgcacttta 3746221 tgtgttcagc aaaaaccaag atctgattga caacgtcctt cagcacacga catcaggaaa 3746281 tgccgccatc aatgatgtcg tcgtccattt cagtgacgtc aacctgccat tcggcggcgt 3746341 caacacaagc ggaatcggct cctatcatgg ggtatacgga ttcaaagagt tttctcatga 3746401 gaagggtgta tttattcagg ccgctgaata atcgcatgat caaaaggcgc ttccttagag 3746461 gagcgccttt tattgtaact ccttgaccaa aagcaattca tcacggatag gtattttatt 3746521 atctgccagt aaaggaattt cgggcttcat ctttctggcc gtctcgactg cattcacaaa 3746581 tagtcgatcc aaccggtacc ctctcttctg ataaaacgct aatgcatgaa tattatcatt 3746641 ggttgtgatc agttttattt gtttgatatt tctctctctg catgcttcct cggctttctc 3746701 tagcagagct gttccgatcc ctttattctc aatgacacta tccagcgaaa tgatttcaca 3746761 ggcatcttct tcaaatatgt atgtaataag gccaacaatc tggttatcat cgttgagcat 3746821 tccataacca tctaattcat cgcagttata aataccgcta gaaataacca tttgcggact 3746881 gccccagtgt ttttgaaaaa acgcggaaac aagatcttta ggtacctggc atgtcggaat 3746941 aatattcata ttttcctcct tttagctgaa caaaaataag agaattaaca acctatttta 3747001 tgtcattaat ccccttatct agtatttact agaacttata acttgtcaaa agctgtctga 3747061 ataccaattg cgtggattga taaggatcaa aatctgaatc ctgagattgg aagatttgct 3747121 ctggggtcaa tgtctctgcg ttctctgata acgtttgaat cagactttcc aaatatccat 3747181 ttaactctga tttggacgat tcatgtaggg attgatgatt tacagcgagt tctctaaatc 3747241 tgttatcact gattaatttt tttcgaagag ctgctagcat caagtcaagc catgcaggct 3747301 ggccaaatgt aatatttaaa gctaacgttg cttgatcaga tttggtggag tgccataaac 3747361 ctcttggcaa atacagcatg gttcccggtg ttaaattaac gatttctgca tctggcagat 3747421 cctcttttgg cggatctcct ttccaatatg actgtaaatc atcaggatag taaggagcct 3747481 ctgataaatc atagtgctgc attggattgc tcacattttc attcttggca agcttccatg 3747541 ttttctcacc ttgaatttga aaaatcaagt tggtgtaggc gtcaaaatgg gctttgaatc 3747601 ccccgccatt tttcgccgcg taaacaatgg ctttggaaga agtacccgca ggcagtctta 3747661 attccgcttt gagtttttct atccaccttc tgacttgggg aataaatagg tcggtgaaat 3747721 caaactctaa tgcagcccct ttttcatacc actctaaagc ctctgcaggt gacacaagaa 3747781 atctgtctgt gatcccttca gattcttcaa tcacagcatc accaacgacc atgactggat 3747841 tattgtagat agccaatacg ttttctagcg ttctaacctt ttcaaacccc ggtatgcttg 3747901 taaatctctc cacttctcct ctggctacca aaggttttac aggccaatat tcttctaaaa 3747961 actcactcat cgttacagga ctgatgatag actccaaaac cgattcggtt acagcactca 3748021 tattatccct cccaaaaaaa gtaacttcac cacaaagata taacattttt ttctaaaagt 3748081 aaatattgac agaattatca gaggattata atatttagtt gtgcgtgata gcctattttt 3748141 ttacaaggaa ggagggaaaa ggatgaaaaa ggcttataag aaacctcgtc tttttgaact 3748201 gcgccgtgct gtagcagctg gcggccatta atctcatata gcatttgaca tctagtactc 3748261 tattttagga gggatgctca atgaaaaaag cttataagaa acctcgcctt tttgaactgc 3748321 gccgtgctgt agcagctggc ggccattaat ctcatatagc atttgacatc tagtactcta 3748381 ttttaggagg gatgctcaat gaaaaaagct tataagaaac ctcgcctttt tgaattgcgc 3748441 cgcgctgtag cagctggcgg tcattaatct tatccaaaac gattaacgtt tgaggctatc 3748501 acgccaactt gataaggagg atgctgaaga tgattacggc tgaagaatgc agaacgtaca 3748561 aagaatttgt tgatctttac caatcctatc tttacccctt gcttggcgcc agactgtccc 3748621 ggatgtattc ccccaaaaac aaagtcatta tcgatatggg cacaggtcca ggttatttaa 3748681 gcattcagtt ggctaaaaga acaaatgcgc acgtgcatgc tgtcgatatt aacccggcca 3748741 tgcatgaaat cgctcaagaa gaagctaaaa aaagcggagt aagcagcctg atttcatttg 3748801 atttggaaga tgtccaccat ttatcttacg ctgaccaata tgctgacttc atcgtctcct 3748861 actcttgcct gcatcattgg gaagacgttg ttaaaggact taaagagtgc tatagagttc 3748921 tggctccggg cggaaaaatt gtcattttgg atacatttaa tccccaagga agccatttag 3748981 agattatgcg aaaacaaatc aaagaaccgg aatacttcag gtttgtaaga gaggcatttg 3749041 aagaaagtta ttcctttgaa gacattcacc agtttgttca ggatgccggc attcccaatt 3749101 attcattaga aacctttcac tttttaccgg aggattttat agaaagctta gatgagctgg 3749161 aggatgctcc cctgtgggaa caaaatgatc aaagtactga tcatgaaatt gagtctgtca 3749221 catggatgtt aacgatagaa aaagaaaagg aaggtgcatt gtaatgatca atgaatcaac 3749281 tgttttatcc aaaaatccag aaatgccatc aagaaaatat ttgaaaagca ttattataga 3749341 gccgggcatc actttaaatg aaatggcatc agatatttat aaccatatcg acggcaaggt 3749401 cagcatacat gatatttgct caaaaatcgt caatgaatat gatgttgatt atcaaacctg 3749461 cttagaagat tgtatggagc tgtttgagtt gcttattgat catgaagcaa tcaaagttaa 3749521 gcagggggca tgagaattgg aaaaacaaaa agtgcttgct ttaccagacg atgtacatga 3749581 gctgagtaca caccgttcta aatcaatcgt aaattacatc atcactctgc ttgcctttgc 3749641 caaaaaacaa ggattgactc atcaagatat tgtaagctgg attcacgagc aatatgagga 3749701 aagaggatat tatgatgagt ggagacacat taacagccaa caaccagttg gatcatttgt 3749761 ggaactcttt ataaaaggaa gacgtttact ttatgacaaa attgaattgt ttgaaacaga 3749821 agataaatat gtcgtaaata cccacacttg gtatgaaaaa gaacctagtg aggccttttt 3749881 ttattttgaa attgatcccg aagaattttc tgcgtacgct tccattctcg caatcgaaaa 3749941 cgcaaaacgt ctcggaatta aaatcgatat tgtaaaagaa acagatgtag agacagctta 3750001 tatctataaa catcaataac gctattggga gggagacata tgtgcgggct cgcgggtatt 3750061 ataaatctgg ctgctccccg ttctcaggaa tgtacctttc atatattgaa aggcatggca 3750121 gatgccatca gctatagggg accggatgat gaacaatatc atattgattc caaagtcggc 3750181 tttgcatttc ggcgattgtc cattcttgac cttgtaaatg gacagcagcc ctttttaaat 3750241 gaggatggat caatcgtcgt tatggtaaat ggagaaattt ataactataa agaactgaag 3750301 gcttctttac acaatcatat gtttaaaacg acatctgatt gtgaagtaat tgttcattta 3750361 tatgaagaaa aagggattgg atttgtagac gacatcatcg gaatgttttc aatagccatt 3750421 tgggacaaaa ataaaaacaa agtattttta gttcgtgacc gctttgggat taaaccgctt 3750481 ttttacacag agctaaaaca cgagcttata tttgcctctg aaataaaatc cctattttct 3750541 catcctcact gtccccgcca atttaattgg aaagaagcac tctcagacat ttggctaagc 3750601 ggggaagcag ccagtaatca taaagaaacc acttcctttt ttgtaaacat ccaaaatctc 3750661 gatgctggcc attatctcga aattaatttg acaacaaatg aacgaaaaac agcaagctat 3750721 tggtctttac aggatatttt gctcaggcaa ggctatcgtg agaatctcca tcccgatgac 3750781 ctgattgaag gatatagaga actgctggca gattcagtcc atagatgttt acaaagcgac 3750841 gttgaagtcg ggttgtttct tagcggtggc attgattcag ctgcagtcgc acattttgct 3750901 gcagaaaaac aggatctcca tacgtttaca gtattaagcc aaagtacatt tacaaatgaa 3750961 gatgcaaaat atgcccattg gctggctaaa gatttacacc ttccaaatca tcaggttctc 3751021 tatcaattag ggaacgatga gttattacaa ccagagtcat ataaacattt gttatggatc 3751081 tgtgaaacac cgttttgcgg accggaacaa ttatataagt ttcatttaca taagtatgcc 3751141 aaagcgataa ggccaaacct gaaagtcatg ctgaccggcc agggcagcga cgaatttaac 3751201 ggcggttaca gcacgacact ttcaccagcc gagaacccaa gttgggaagg atttattgaa 3751261 tcggtcaata cgatggagat gaaccggctg catcggctgc agggaaatat ctttagagtg 3751321 tgggaggagc attttggact ttctcctata aacctttctt atttaaagag caatgattcc 3751381 agccaagcag atccttggca atcgtatgtc ctgacaaaat accgtgatct gcaaatgtat 3751441 aattgctggc atgaagatcg gatcgccgcg gctaatcata tcgaaaaccg tgtaccgttc 3751501 ttggaccatc ggcttgttga atgggtttgc ggaatacctg atggactccg taaagacttg 3751561 ttatgggata agtcggtatt gcgaaaatca ttaacaaatg agctgcatac aagctatacc 3751621 caccggccaa aggttccttt tttctatggt aaggacgtga gatatacaca taaaatgatg 3751681 tttcatcttc tgaagaaaaa caattatcag cttatagagg aggccttctc tcacagcgat 3751741 gcctccagca taatacaggt tgaacacatt catgccatca tgacatattt ggaggatgat 3751801 cctgagttta caaattttga atttttatta agactggtga acatgggact tttatcaaaa 3751861 atgactaaag aaaccccttc tgttcaatta gacataacca gccatttaga atcgataaca 3751921 ataaaagact ggcactcaca ggaaggtgat attgccagtc gtttaaatat ctcagccaat 3751981 aagtgtgaag gacaagatat tttggcgcta aaccctggcg tcactctgtt aaggccggaa 3752041 agcgatagtg agcattgcat ctacattgcg gaagaaggat ttattcagtt tattgtttcg 3752101 gaggaagacg tcggagcttg gctgcatatt ctctgcgata ttaatggaaa agacacactt 3752161 catacgattt tagacagaca tggtgtcagc cttgaagaag tggccaaata tattcaagaa 3752221 gccatcgaac acaatatcat tttgatcaaa caaaaaaatc tgccagaagg agcatataga 3752281 tgagcatctt ttattcgttt tccgcactta ggggattagc aatggggatt ttttcgccta 3752341 tttggattct ttatctgata tctaaagatt atgatttcct tcagattgga ttaatgggag 3752401 cggtacttga aattgctaag cttatatttg aagttccttc cggcgttttt gctgatcgtt 3752461 atggaattaa aatttcaatt gccagttcat tctttttctc catccttaca tgggccttct 3752521 tcccttttat cgattcagct gctatttgca tactggctat gatcatatgg gctttatcag 3752581 attccttaat ttccggttct tttgaaactt ggatgagccg tgtcgcaggg gaagatcgat 3752641 tcggcaaaga aatgatgaaa aacacacaat tgctaatcac ttttttaatt attggaagta 3752701 ttgccagcgg gtatttgtat tcattaaata tctattttcc tttcctgctc gttatggtga 3752761 tctacttatt actatttatt tggatgtctg tatttattaa agtcccttct gtttccgaaa 3752821 caaatcatgg ggatcagaac caacatgatt cgataaagat tatcaaagaa agtttaaaaa 3752881 ttatctttaa caaaaaaagg gttcttttaa tcgtcatagc cggtttcttt acagccacag 3752941 cctatgacac aatttcccgt tactggcagc cttttttgag tgatttaggc ttttcagaaa 3753001 agtcactggg atatattttt gccctaggag ggtttaccgc tctcgttctt ttgacattaa 3753061 ccatcaggtt cgaaaagaag atcgaaaaaa atccatatct cgctttaacc tcattggatt 3753121 ccatgggcat ggtcatgact tttctattgt ctagagcatt caggccgctg ggcattccat 3753181 gtacagcgtt tttgcttgca attgaagata ttcatcatcc gatcgtaaca agttacttaa 3753241 ataagttttt ccccgattca tacaagaaca cacttttctc gttaaactca ggggtaggag 3753301 caattggaga aattctttcc ggtgtcattt tcggcatcat ttccgcagcc tttgggctct 3753361 ctgccatgtt tgttgttgta gctgtatttc tattaatccc tattatcctt tatacgatag 3753421 tgcctaagat taaagacaat gatatgaaag ttcagattga aaaatcccag caagtgtaaa 3753481 tgttttgtat cacagtaaga agaccttctt attaaaagaa ggtcttctgc tattctattc 3753541 agttatttcc caaaagccat cagcttcgta taacttccaa tataaagtgt tccgtcctca 3753601 gcgagctgag gagaagacac gacgttgctg tcggtttgat agctccataa ttcattgccg 3753661 tttgcgtctg ccgcataaac cttcatatca tctgacccga aataaaccgt tcccttcgcg 3753721 tcaatcagcg gcgccgttct gacagggccg tctgtgtaga atgaccagtt catatccccg 3753781 tttttgctga tggaaaacag ctcgccgctt cctgagccga tgtagatatt gccattatga 3753841 tcaatcgcag gagatgagct ggagaacccg tttagcggga atgtccattt caaactgcct 3753901 gttgatgtat aagcatacag ctgtccatct tggttgccgg cataaatgtt tccgtcctta 3753961 tcaatcaccg gatatccttt aaacgcattt gacgtcgttc tggaccattt cacctgtccg 3754021 gttccggagt tgatcgcata aaacacgtaa ttatatgtgc cgacatacac ggtgccgttt 3754081 ttggcaagca ccggcacaga gctgacgacc ccatttgttt tcaacttcca gcgctctgtc 3754141 caggttgatt ttgacgtcgg tttgatcgcg tgaacataat tatcaagtgt tgagaaatac 3754201 aacgtcccgt ctgaaccgat caccgtttca gagcttggcc cgccgcttaa cggaaccgtt 3754261 gttaaaattt ctcccgtttc tttgtcaata aaataaatct ttttgtcata ggatgccaaa 3754321 tagataacgc cgttggtccc aagtacagga gattgcgtat atgtttttcc aagattgccc 3754381 gtcacccatt tgactgagcc gtctggatta aaggctttca tttccccgtc tctggaatga 3754441 agatatactg tgccgtctcc gtcaatcaca gcccccgctc cattttgcgg agtcgttctg 3754501 atgtcgtttt gccatttcag cgtcccgtct gtatttccgg cgaaccggct ttcgcgtgac 3754561 cagttaaaca tggcaggcgc catcgcttgt acatcatatc ttcctggcaa aaagccagat 3754621 gctccattat tttgagaaaa caccgtttcc gccgcataag cagctgtcgg ctgaagcact 3754681 ttggcagcgg gcacatcaga aacagcgccg gccgaaacag ccgccgccac cgcagctccc 3754741 gcaatcaaag ctttcatacg aaatgacttg accatcattg agacccccat tatatgtaac 3754801 ttctaatttg tgaccatcat aacatattca tccattttat aaatctattt cacaaaaaca 3754861 tcacaaacta gaaaactatg taagagtatt cacggacgtt ttttcagcac ccgatcgaaa 3754921 tgcagccaca aaccaaatga cgttgacagc agccgcagcg agactaactc ccaaaacaaa 3754981 gatcacctca gaaagcagat ggtcactaaa gaaactaaac atcaagataa aaccggccga 3755041 agacaaatga atcaaaagcc cgaagccgca aagcaccgcc atgacatacc tcattgcatc 3755101 gactccgagc atataaacga gaaatggaat gaaatacaag acaaggatca taccgacagc 3755161 tgaccacatg ccagctgaat taaactgatt ggccgccgct cccgttccgg ccagcggcga 3755221 aagtgaagcc gccacaatca cggcgcaaaa aagaaacgca gaaatggttg tcatgatcgc 3755281 cacgctattt ttttttgaca tcaaactcct cctttaatag aaatattaac cttttttatt 3755341 ataagtaagt tgaatgttat attcattata tttttaaaaa attccagaat acatacacaa 3755401 atgctatgct tctttctagt atatttatat agtaaaaaac aaaggataaa agactcattt 3755461 ttctgtaata tcaggatttt atcaccatac catattgcat gtacatgttt ttcaaagtat 3755521 actattccag attaattcag aggagagaga aaaatacatg gaaaaaccag caggattttg 3755581 gattcgtttt ttagcttatt ttattgacgg cattattgta tctgttccta gttatattat 3755641 tctatttatt atcaattctg tgtttgtagc tggggctgtg gcaacaaacc cttacatgac 3755701 ggaagaagag tatttagtga aatacatgac gcttgcattt ttgcctacta tgctgatcat 3755761 gatcgtcatc agcgtgttat attacgggct gctcacagct tctaaaatgc aaggcacact 3755821 tggcaaaaaa attcttggcc tgaaagtggt caatgaacaa ggtgaacggg tttctgtcgg 3755881 acagggaatt ggccgttact ttgcctatat cttatctgga atcatctttt atatcgggtt 3755941 tatcatgatc gcctttggag agaaaaaagg cctgcatgac atcatttgca aaacacgtgt 3756001 cgtgtataaa taatagaaaa aagtctagac gccaataggc atctagactt ttgttttctt 3756061 tgcaataggc tgccacgaca gatacgtagc gcttctccac aaccactcaa acggccccat 3756121 ccgaaagaca cgaagccaaa ggtggctgaa gaccatttga acggcacaaa cagcaattgt 3756181 aatgagcaca ccggcagcag ggtacacttt tccatacagg cccaagccgt aatgataaaa 3756241 aatccaagta cacacaatag actgcatcaa ataattggta aatgccatcc tcccaacagc 3756301 ggagaatgat tgcagcactg ttctcactct tgttttatga taaagataga caaccgttgt 3756361 aacatagaaa aacatgagga aaggcgcgcc aatcagcaaa catatttctt tatccgttac 3756421 actgtacagc acctgggcgc cgatgccgat gacaagccca gccatccata atcgttttaa 3756481 tcctttgcga tgcttttccg gttcatgcaa ataccgtgat tttgctgccg cagctcccag 3756541 caaaaacatg ctgaaatatg gaatggatgc aaagaagtag ttgagcggat tatacgtaag 3756601 catgccattc gaagacatgt aaacaagacg gtcgtggatc cgctgttctg caatatcctt 3756661 caggctgccg cttccataaa catgaatcgc ttgttttgcc tgctgtgtta ccgcttgtac 3756721 ccattcctgt ccgtttgatt gatcaaaact tgtcaacatg aacggaatgg aaaacagaag 3756781 atacaaagag accgcccata tcagcagtgt tttcggcttt gcttttcgaa acaagagcag 3756841 gacaaatccg agcagggcat attctgttaa aatatccccg tcccatatca aaaaggcatg 3756901 aatcgttcca aacaagagaa gcgccattaa ccttctcaca tataacggaa caaaccgttt 3756961 ccctttgttt tctgctctct ccatcatgac aaccatgcca aatccaaata aaaaggaaaa 3757021 caataaaata cattttgttt gaatgaagaa tttcagtatg tctgcggcgg caaaatcagc 3757081 ttcagaccac ttatccatga aaaaattctc ttttccaagc atagacaaat acatatccgg 3757141 ataactgaaa tgtgccagat tgacaaataa gatgccgaaa atcgccattc ctctcagcac 3757201 atcaagcaca ccgatccgct catttgttaa agtcggctgt aatgaagaca tagccatcac 3757261 gctccttttt tctgtacctt aagggtagga aaaaatgaag cgcggtaaca tcgatttagg 3757321 tgtcaggccg gcatgaaaac cttacaatct tgtcatcttt atggtttcat cacctttaaa 3757381 tctaatgctt cgatattctg caaaatgcga tcaaagcgca aagcctgagg ctcacatggg 3757441 aagatgtggc cttcatacgg gtcgcctaac gtccggaaaa acggttcaaa taaaccagga 3757501 accaatacgc ccaccatctt tgtatagtga gaatcaaggc gataggagtg aacggtattt 3757561 gcagggacat gcaggaaatc tcccggattc agctgaattt cctggccatc tgtccacatc 3757621 gtcatctggc cttcaaggca ataaaatgtt tctgtatgat attcatggta gtgatcaacg 3757681 attcggtcac ctttagggcc ttcagatgat acgacgataa actggccatc tgtatttttt 3757741 tgtgcagcca caatgcggtg aagctgatct ccagtcaaca gacgatctcc ttctccagat 3757801 tcaagaacgt atggaaccgc tccatctggc agctctgtaa gttccgctaa tttggccgaa 3757861 catgcaggct ttgcttcatc tagaaataca atgtccgcta cagcggctgc ttctgcaaat 3757921 cgctcgtttg agacttcttc gcttgcgtac ggcggatgtt cagcgtgatc atacggattc 3757981 ccaataacgg aatacaagtg cgctacgttt cctttcatcg tgtaagacac cagtcttgtt 3758041 ctgtggctct gcatccggta gctgtgcggt gttcccgccg gaatgttggc ataatcacct 3758101 gatattaata aatagcgttc accatcaagt gtcagttcca gtttcccgtc caaaacgaga 3758161 attccttcat gtgtgtcctt gtggacgtga agcggaaagg catctccttt tcccccggaa 3758221 agaagcacga tctcaaacaa atcacctgtg ctcctcccat tcgccatcac cgtggcaacc 3758281 tgtctgccga acagatagcg ctcgccttct ccgctccgga gcaaataagg cattttttct 3758341 ttaggcaatg aatgtgtaca taatgttttc atattatcgc ttcctccaat ttagaccagt 3758401 ctatatatta tcattcattt gtctagaccg ttctatataa ttgtaggaga aaggataaca 3758461 aaatgctacc ctttttttct caccagcact ggtatttgtt cggcaatgag aagaagaggc 3758521 gttttgtctt tattcgttaa cgaaagcatg atgccgccct caatcatcga attaatcagc 3758581 gttccaagct gatttgcttc ttcttctgca aatccgtttt ccattaattt tctggcaaaa 3758641 accgcttccc agcttttaaa caccttcatg caaaccgtcc gcagcggttc actgattaac 3758701 gctgtctcac tcgccagcaa accgactgga atacctttaa tgctttctgt gttgtcaaat 3758761 tggctggctg tttttttgat aaaaagctga atcgcttcaa caggatcaga ggattcatcc 3758821 atgctttgct gtatcagatg ttcaacgatc ttacctgtat atgtaaccgc ttcaattgct 3758881 agttcttctt tgccattcgg aaaaaagtga taaagcgatc cttttggagc accgctttct 3758941 tttacaatct ggttcaaacc tgtcgcgtga tatccttgca gctggaacag acgtgacgcc 3759001 gtgtgaagga ttttttcacg tgaatctcct ctgctagtca ttaaaacatt ccctcctagg 3759061 tatggtagag cgacttatat aatataaaaa agaaccctgt gattgtcaaa aggggtaaga 3759121 cccttccgga tggggtaatg tacaaaaaca gcgtctagga gggatctctc aatgacaatc 3759181 gatcattcag tcacaaatac agagcagctt gaacaacaga accccgccat aaaaacaaag 3759241 ctcaaactga aaaagcttaa ggatcaggtg atcgtcatta ccggcgcttc aagcggtatc 3759301 ggacttgtca cggcgagaat ggcagctgaa aaaggcgcaa aggtcgtggc agcagcgcga 3759361 aatgaagagg cgctgaagga gctcactgat gaacttaagg aaaaagggca cgacgccata 3759421 tgggtaaagg cggatgtcgg aaaagaagag gacgtcaacc gcatcgcaga aaccgcgatc 3759481 agcacattcg gccgctttga tacatgggtc aacaatgcgg ccgtctcgac tttcggacac 3759541 gccatggacg tcaccgtcga agacatgaag cgcatgttcg acacaaattt ctggggacct 3759601 gtttacggaa caagagcggc tgtcaaacac tacaccggca gaggtgtgcc gggcgcactc 3759661 attaatgtag gaagcctgtt cggagacagg ggaacggtca ttcaatccac atatgcatct 3759721 gccaaatttg cgcttcacgg ctggacggaa agcatccgaa tggagcttga aaaggaacag 3759781 gcgcccgtct cggtaacgct catccacccg ggcagaattg acacaccata taacgagcat 3759841 gcgcacagct acctcgacaa acagccggct cattaccgct ccatgatcta tccgccggaa 3759901 gcggtcgccg aagcgatcct gtttgccgcc gaacacccta agcgcgacat gtacatcggc 3759961 tcacaggcca aagccatcgc catgctgggc gcgctttttc ctcgtctgac cgacagactg 3760021 atggaaaaaa tcatgtatca cagccagcat gccgaaagac cgtccaatcc gagagaagaa 3760081 agcgctcttt atgatgctgg ctgcggtatg catgacagag gcacaaataa aggatggatg 3760141 aggtcaagaa gctactacac aaaagcgacg aagcgcccaa ttgtatcggc ggctgttgtt 3760201 gccggactag tggcttgggc tgccgccaaa cgatgcagat aatctctgac cataagaaaa 3760261 acccatgctg ttccagcgaa ccatgggttt ttcagctgtt aatcgataaa agccttgttc 3760321 atacgctgca gcagctcgcc gaacatctct ttttcctgtg ttgaccattc tttcagcatc 3760381 tgttcataac gttcaaggcg cttttgctga tcggctttta atagttgttt gccgagtttt 3760441 gtaatggtaa acaggctgac tctcccatca gacgggtctg agaaacgata gatgagctcc 3760501 tttgcctcta atgcagctgc ttgtcttgaa agagtagaaa tatcaagctt aaacgattca 3760561 gccaattcct taacacgagc aggcccaaac tcatccaatt gtctcagtaa taagtacgaa 3760621 gatctctcca aattccctgt tcttttctcc gattgatcca gataaacagc tctcctgata 3760681 aaagtcgtca gctcatattc aattaattca actggatttt gattttgcaa tcgctctcgc 3760741 tccctattcc aatctccggc attgacaaca tcatatatac ttgtataata caaatgtaca 3760801 ttaactgaat aaatacaagt cgttatatga ctaaatcaat tattatactt gtatagtaca 3760861 atcatataaa aagaaagtaa agcgattcct cagaaccatc ctagaagcaa gcaccagaaa 3760921 ggaggaagct gttctgattg gagagcagca cttgatgtga aagtcatacg aattattttg 3760981 caagtgttga tattatatgt attttttatg atcggggaag ccattcagca tctgtttcat 3761041 ttacccgtgt caggaagcat cgttggattg gtattgcttc tgatctgctt gggcctccgt 3761101 attgttcccg tctccatcat tgaagacgga gcagggtttt tattatcctt ccttccattg 3761161 ttgttcatcc cggcaatgac aggagtgata aactatccgt ctctcatttc attcaatggc 3761221 ctgatgctgc tgattacagt cgttctcagc accatcgtca cgatcattgc ggctggattc 3761281 gccagccagc tattagagaa aaaagcaaaa aaacgggagg agaaagagaa atgcagcaag 3761341 catgtatcgc gatcattata attcttttaa cagttgccgc ttatttagcg atggtcaaac 3761401 tctataagcg attcccgctt ccatttctga tccctgttct gacaacgaca attttgattg 3761461 tagcggcttt gatgatgttt catgtttcct atgaaggcta tatgatcggg gggaaatgga 3761521 tcaattcttt gcttgggccg gctgttgtgg cgctggccta tccgctttat aagcaatggc 3761581 atatcattgt caaacattgt gttcccattt taggcggcgt cctggtcggc ttatgcatgg 3761641 gaatgatcag cgggctgatc ttcgcagaag cattcgggat tgatcatgat ctcttattat 3761701 ccattctgcc aaaatcgatc acaacccctg tcgctattca gatcgccgcc ggtcttggcg 3761761 gcgtcccttc catgacagtc gtatttgtca tgattgcggg cttttcaggc gtcatcctcg 3761821 ggccgctttt cctaaaatgg cttcgcatac gcagctccct aggacaaggc attgcattag 3761881 gcagcgcctc ccatgcactg ggtacctcca aagcgttgga atatggggaa ttggccgtat 3761941 ccatgagttc cgtctccatg acgctttgtg cggtgctcgg ctcattcttc ggcccgctcg 3762001 tcgtctggct gtttcatatt taacaaagaa agactgcccc gggggagggc agtctttttc 3762061 gtttaagaag caaaaaaatc aatcaacggc tgaaagtcct tagataaatc aacgtcattc 3762121 ggttctgctt gaagcaggcg gtcaatcata cgctccagct cctcaacatc attcttatcc 3762181 gtatattcaa tgaagtttaa gctttcaagc caatcccgat atgaatgttt ggctttgcca 3762241 tagctgtttc caaagacaag gcaaggtgtt ttggtgataa tcgagaaaat catcgcgtga 3762301 aggcggtcgg taatcaccaa tttactggag ccgatgcggt ccagcatctc cataaaatgc 3762361 ttttcacgat cagcgtaatc gatggtgtct accgtatcca gcaccgtatc ggtacgctct 3762421 gtgtaagttg ttttttctgc ccattgcttc atctgtgaaa taaaatcttc gtcagtcact 3762481 ttctccttat ccgctcttaa aataaagaga acgccgtccc gctcgagctc tcgcggcaca 3762541 atatccaagg aaagcaccat gtccggtgta aagatcacat tggagttgaa ggtctctttc 3762601 acaacatcca gtgtttgcgt ctcacgcgca gcaatcgtta agtttgtatt ttgatggtac 3762661 gcatcctgtg tttttttctt ttccttctgt ccttcctctg tatcctcaaa ataaacggat 3762721 tgtggcagag aaattgattt gtagtcttta aacgccgaaa agacctttct tctgtcttcc 3762781 tcaatatcga gataaaggtt tcctaaattc cctccgcctg taaagcagac aatatcgtct 3762841 tcacgaatga tctccttcac cagttcaatg ccctcatccg tcgcataatc cataatctca 3762901 atgtattcat aatacggaaa atgatttttg ataaatttct cttccgcata cgcaatcgct 3762961 tggtcgccaa tgtttgtgta gctaggggaa ccaaacaaaa atacttttcg tttatcattt 3763021 aacagagctt ccggctccac atttggcgca atgcctttta ctagtttttt gcctttgatt 3763081 tcttgtacag tcatatctgc gtcctccttc tgggatgaat tcctcattgt gtgttaactg 3763141 tctctaccca aaaagaagga tggctatgca ttggcatgtg catcggctat atcagaaaca 3763201 tcgttttcgc caatttgata gacgctgcaa tgtcccgcgc cgttctttcc atatattccg 3763261 cggcatgttc aaacgcgtct tctagtggca cggctccggg gacgatgctg aaaagcgcat 3763321 cgattccgtg ttgatagacg gcattactgt ctcgggaaat tgatcccgca atgccgataa 3763381 cgggcacatc gtatgattta gcggccttgg ccaccccgat cggtgttttt ccatgaaccg 3763441 tttggctgtc gattcgtccc tcgccggtaa tcacaaggtc tgcatcctga acgatacttt 3763501 caaaatcaac cgcttcaagg acaatatcaa tgcctctttt caggtcagcc tgaagataag 3763561 ttagcaggct ccatccaaga ccgcccgctg caccggcgcc ctctgtatct cggaaggttg 3763621 atccgagcgc tttttctgcc atatcagcga aatggcttac gttctggtct agtacatcca 3763681 acatgtcggc cgtcgcgcct ttttgcggcc cgaaaacagc cgtagcaccc tttggtcctg 3763741 ttaacggatt gtccacgtca caggcaactt ccagtttgac attccgcaat ctggaatcaa 3763801 gcccgctcac atctattgat gcaagctgag ataacgcgcc gccccctggg ccaatctcgc 3763861 tgcctgagtt atcaagaagc cttccgccca atgcctgaat catcccggct cccccgtcgt 3763921 tcgtggcgct tccgccgatt ccgatgatca atcgctccgc tcccgcatca agagctgctc 3763981 cgattaattc tcccgttccc cttgttgtag tgatgagcgg atttcgctta tctacaggca 3764041 ccagatgcag ccctgaagca gcagccattt caatcacagc tgttctccca tctcccatca 3764101 tgccaaagaa agctctcacc ggttccccca gcggccctgt gacaacttgc tctatgatcc 3764161 ttccattggt cgcatcgacc agagattgaa cggttccctc gccgccatcc gccaccggca 3764221 attttctgta atcagcaccc ggaaagaccg atttgaaacc tctttctatc gcttcggctg 3764281 cctccagagc tgataagctt tccttaaaag aatcaggtgc aatgatgatt ttcatccaaa 3764341 tcgcctcttt caaaacatga ttcacttaac ctattgatct ccaatgtacc ataattgatc 3764401 tggaaataca taccatgcaa tatggtaaaa atttaaataa aaattagaaa tgaaagtgtt 3764461 tgcataaaag aaatattcac gttatcatac ttgtatacaa gtatactcct tgagtgagga 3764521 aggtgagtgt atgctagact ccaaagacct gttgtatccc gcaaaatggc tctcaaaagc 3764581 gtcaaccgga gttcgtgtcg catacgagct gagaatgcgg atcgtttcag gtctgattga 3764641 aagcggtacc attttatcag aaaatacaat cgccgccgag ttttcagtaa gccgttcgcc 3764701 ggttcgcgaa gcgctaaaaa tactcgcatc cgaaaaaatc atccgcttag aacgaatggg 3764761 agcggtcgta attggtttaa ctgagaagaa aatcgcggaa atttatgatg tgcggttact 3764821 attagaaaca tttgtctttg aacggcttgt caaaatagac attgagcctt tagttaagga 3764881 tctcagcaaa attcttgaaa tgatgaaagt ctcaatcaaa tatgaggatg ctgacgaatt 3764941 ttcatttcaa gatgtgctgt tccatgaaac gattatccga gcgattgatc attcatacat 3765001 tcagatgatc tggaacaatc taaaacccgt catggaaagc tttattcttt tatcgatgcg 3765061 ggtacggtta aaggaaaagt atgaagactt cacaaggatt ttagataacc acgagcttta 3765121 tattcaagcc atcaaaacaa aggatagggc gctgatgatt cagtctcttc accaaaactt 3765181 tgatgatgtg caggataagg tagaagacct atggctctca caacaaatgc tggcaaaagg 3765241 agctgaatac aacaatgact agttatatgt taggaatcga tatcggcacg acaagcacaa 3765301 aagctgtgct gttcagtgaa aacggagatg tggtacagaa agaaagcatc ggctacccgc 3765361 tctatacacc ggacatctca acagctgaac aaaatccgga agagattttt caggcagtca 3765421 tccatacaac agcgagaatt acaaaacagc atcccgaaaa acggatctct ttcatttcgt 3765481 tcagcagcgc catgcacagc gtcattgcaa tcgacgaaaa tgacaagccg ctgacgccat 3765541 gcattacatg ggccgacaac agaagtgaag gctgggcgca taagatcaaa gaggaattga 3765601 acggacatga ggtgtacaaa cggacgggaa caccgattca tccgatggca ccgttaagta 3765661 aaattgcctg gatcacgaat gaaagaaaag aaatcgcttc caaggcaaaa aaatatatcg 3765721 gcatcaaaga atacattttt aaacagctgt tcaatgagta tgtcatcgat tactcattgg 3765781 catcagcgac aggcatgatg aacctgaagg gcttggattg ggacgaagag gcactgcgca 3765841 tcgcaggcat cacgccggat cacttatcca aactcgtgcc gacaaccgag atctttcagc 3765901 actgcagccc ggaaatagcg atccaaatgg gaatcgatcc ggaaacgcct tttgtcatcg 3765961 gcgccagcga cggcgtgctg tccaacctcg gcgtcaacgc cattaaaaag ggtgaaatcg 3766021 ccgtcaccat cggtacaagc ggtgccattc ggacgattat tgacaagccg caaaccgatg 3766081 aaaaagggag aattttttgc tatgccttga cggacaagca ttgggttatt gggggacctg 3766141 tgaacaatgg gggcatcgtc cttcgctgga tcagagacga gtttgcctcc tccgaaatcg 3766201 aaacagcgac acggctgggc attgatccat atgacgtgct gacgaaaatt gcccaacgcg 3766261 tcagacccgg ttctgacggt ctgctgttcc acccatatct cgccggagaa cgcgctccgt 3766321 tgtggaatcc ggatgtacgc ggctcatttt tcggcttgac catgtcgcat aagaaagagc 3766381 atatgatacg cgcggcattg gaaggcgtca tttacaacct gtacacggtg ttcttggcgt 3766441 taactgaatg catggatggc ccggtaaccc gcatccaagc gacagggggt tttgcaaggt 3766501 cggaggtttg gcgccaaatg atgtcggata tcttcgaatc agaggttgtc gttccggaaa 3766561 gctacgaaag ctcatgtctc ggcgcctgca ttttaggcct gtatgcaaca ggaaaaatcg 3766621 attctttcga cgccgtgtcc gatatgatcg gcagcacata cagacatacg ccgatcgaag 3766681 actcagccaa ggaatacaga acattaatgc cgattttcat caatctatca agattattag 3766741 aaaatcaata tacacaaatt gcagattatc agaggggctt aatcacacac aaatagtaca 3766801 tgacatgaag gggagggcat taccatgccg ttaatcatcg ttgcacttgg gatcttagca 3766861 ttactatttc tgattatggg cttaaaatta aacacattta tttccctgct ggtcgtatcg 3766921 ttcggcgtgg cactggcact cgggatgccg ttcgataaag ttgtcagctc catcgaagca 3766981 ggaatagggg ggactcttgg ccacatcgcg ctcatcttcg gactcggtgc gatgctgggc 3767041 aaactgatcg cggattcagg aggcgcacag cgcattgcga tgacgctcgt caacaaattc 3767101 ggtgagaaaa atattcaatg ggccgttgtc attgcctcat tcattattgg gattgcgtta 3767161 ttttttgaag taggactggt tctattaatt ccgattgtct ttgcgatttc aagagaattg 3767221 aagatttcta ttttatttct cggaatcccg atggtcgcgg cactatccgt cacacacggt 3767281 ttcctgccgc cgcacccggg acctacggcg atcgccggtg agtatggcgc aaacattgga 3767341 gaagtgctgc tgtacggctt tatcgttgct gttccgacag tgctcattgc agggccgtta 3767401 tttacaaagt tcgcgaaaaa aatcgttcct gcatcatttg cgaaaaacgg caatattgca 3767461 tcactcggca cacaaaaaac atttaacctt gaagaaacac ccggctttgg aatcagtgtc 3767521 tttactgcaa tgctcccgat tatcatcatg tcggtcgcga ccattatcga cctgcttcaa 3767581 gaaacaatcg ggtttgcaga taacggagtt ttagctttta tcagattgat tggaaacgca 3767641 tcgactgcta tgattatttc gttattggtc gcagtctata caatgggcat caagcgcaac 3767701 attccagtca aaaccgtgat ggattcttgt tcaactgcca tttcacaaat cggcatgatg 3767761 cttttgatca tcggaggagg cggcgccttc aaacaagtgc tgatcaacgg cggtgtcggc 3767821 gattacgtag cagacttatt caaaggaacg gcattatcgc caatcattct ggcatggctc 3767881 atcgcagcga tcctgcgcat ttctctagga tcggcgactg ttgccgcact aagcacaaca 3767941 ggtctggtca ttccgttatt gggccattct gatgttaacc tggcgttagt cgtactcgca 3768001 acaggagccg gaagtgtcat cgcttcacac gtcaatgacg ccggcttctg gatgttcaag 3768061 gaatacttcg gattaagcat gaaagaaaca ttcgccacat ggacattgct ggaaaccatt 3768121 atttccgttg ctggactggg attcatttta ttgttaagtt tagttgtatg aaattaagaa 3768181 ggagctgtaa cacatgttca attcgattgg tgtcataggc ttaggcgtaa tgggaagcaa 3768241 catcgcctta aacatggcaa ataaaggcga aaacgtcgct gtctataatt acaccagaga 3768301 tttaacggac cagcttatcc aaaagctgga tggacaatct ctcagcccgt attacgagct 3768361 tgaggacttt gttcaatcgt tagaaaaacc aagaaaaatc tttttgatgg tcacagcggg 3768421 aaaacccgta gattccgtca tccaatcatt aaagcctttg cttgaagaag gcgacgtcat 3768481 catggacgga ggaaactccc actatgaaga cacagaaaga agatatgacg agctgaagga 3768541 aaaagggatc ggctacctgg gagtcggcat ttccggcggt gaagtcggtg cgttaacagg 3768601 gccttccatc atgccgggcg gagatcgcga cgtctatgag aaagccgctc ctatcctgac 3768661 gaaaatcgca gcccaagtcg gagatgaccc ttgctgtgtc tatatcggac caaaaggggc 3768721 agggcacttt acaaaaatgg tgcacaacgg cattgaatat gccgacatgc agctgattgc 3768781 agaagcttat acgtttctaa gagaaacgct tcgtctgccg ctagatgaaa ttgcatctat 3768841 ttttgaaaca tggaatcaag gtgagctgaa aagctattta atagagatta cagctgagat 3768901 tttacgcaaa aaagacgaaa aaacaggaca gcctctgatc gatgtcatcc ttgataaaac 3768961 cggccaaaaa ggcaccggaa aatggacgag catgcaggcg attgataacg gcatcccgtc 3769021 cacgatcatc acagagtcct tgttcgcccg ctacttgtca tctttaaaag aagaacggat 3769081 ggcagctcaa gatgtattag caggcccgga agccgaagaa aaacacttgg ataaagacac 3769141 ttggattgaa tacgtcagac aggctcttta catggggaaa gtatgcgcct atgcacaagg 3769201 ctttgcccaa tataagatgt catctgagct ttacggctgg aatctgccgc tcaaagacat 3769261 cgccttgatt ttccgaggcg gctgcatcat ccgcgctgat ttcctaaacg tgatcagcga 3769321 agcattcagt gagcagccaa atctggctaa cctgctgatc gcgccttatt tcacagataa 3769381 gctccatgcc tatcaaacag gcctgcgaaa agtcgtttgc gagggtatca gcaccggaat 3769441 ctctttccca tgcttaacta ccgcgctctc ttattacgac ggctaccgca cagggcgttc 3769501 caatgcgaac ctcttgcagg cacagcgcga ttactttggc gctcacacgt acgaacggac 3769561 tgatatggac ggcgtcttcc atacgaattg gtctgaataa cctgtattaa aaacacggtc 3769621 agtttcaact gaaccgtgtt tttttcttct atcccaaaca acagaagaca taagttatgt 3769681 tttaaatatc ataaacagtg atacaataat agctagaaac aatccccaag atcatcatgt 3769741 gacagcagat tgctgttccg ttctattctg cttttggcca ttgtcctttg cccttgacca 3769801 tggtgtcata aaatgttcaa atgccaaaac ggcctggcat tctgatttac aaaagtccct 3769861 gaaaacctta tctaattgag aatcagcctc tcatttatta taaaagaaat gcctaaatcc 3769921 tacctgtcac acctttatta agatgaaaaa aagtaggtta tggcttgaca aaaaatatat 3769981 attaattaat aattcatata taattagaat tattattgaa agcgattatg ctttctaata 3770041 catttttagg aggaatatac attatgtctt taatcggtaa agaagtactt ccattcgaag 3770101 caaaagcatt caaaaacggt gaattcatcg atgtaacaaa cgaagatttg aaaggccaat 3770161 ggagcgtatt ctgcttctac ccagcagatt tctctttcgt atgcccaact gagcttgaag 3770221 atcttcaaga acaatatgct gcacttaaag aattaggtgt tgaagtatac tctgtttcta 3770281 cagatactca cttcgtacac aaaggctggc atgacagctc tgaaaaaatc agcaaaatca 3770341 cttacgcaat gatcggtgac ccatctcaaa cgatctctcg caacttcgat gttcttgacg 3770401 aagaaactgg ccttgctgac cgcggaacat tcatcatcga tccagacggc gttatccaaa 3770461 ctgttgaaat caatgcaggc ggtatcggcc gtgacgcaag caaccttgta aacaaagtaa 3770521 aagcagctca atacgttcgt caaaacccag gtgaagtttg cccggctaaa tgggaagaag 3770581 gcggcgaaac tcttacacct agccttgatc tagtaggtaa aatctaagga gtgcattcaa 3770641 ttggtacttg atgcaaatat caaagcacaa ttaaatcaat atatgcagct aattgagaat 3770701 gacattgttc tcaaagttag cgcaggcgaa gatgacactt ctaaggacat gctggctctc 3770761 gttgatgagc tggcttccat gtcatcgaaa atttcagttg aaaaagctga attaaacaga 3770821 acgccgagct tcagtgtcaa tcgtgtcgga gaagacactg gcgtgacttt cgccggtatc 3770881 cctctgggcc acgaattcac atcattagtg ttggcgttgc tccaagtgag cggcagaccg 3770941 cctaaggtag accaaaaagt cattgatcag gtgaagaaga tcagtggtga ataccacttc 3771001 gaatcttata tcagcctgac atgccacaac tgtcctgatg ttgtacaagc tttaaacatg 3771061 atgagcgtgc tgaacccgaa cattacgcac acgatgattg acggtgcagc atacaaagca 3771121 gaagttgaaa gcaaaaacat catggcagtg ccgaccgttt acctgaatgg cgaatccttc 3771181 ggaagcggcc gtatgacgct tgaagaaatt cttgcgaaaa tgggcagcgg cacagatgca 3771241 tctgagtttg ctgacaaaga gccgtttgac gttcttgtgg tcggaggcgg acctgctggt 3771301 gcaagtgcag cgatctacac tgcacgtaaa ggcatccgaa ctggtgttgt cgctgagcgc 3771361 ttcggcggac aggttctcga caccatgagc atcgaaaact tcatcagcgt caaagcgacg 3771421 gaaggaccga agctagcggc aagtcttgaa gagcatgtga aggaatatga tattgatgtc 3771481 atgaaccttc agcgtgcgaa acgccttgag aagaaagatc tgttcgaact tgaactcgaa 3771541 aacggcgctg tcctgaaaag taaaacagtg atcctttcaa caggtgcacg ctggcgcaat 3771601 gtcaacgtcc ccggtgaaca agagttcaaa aacaaaggtg tcgcatactg cccgcactgt 3771661 gatgggccat tgtttgaagg caaagacgtt gcggtaatcg gcggcggaaa ctctggtatc 3771721 gaagcagcga ttgatcttgc aggtattgtc aatcacgtta ctgtactaga attcgcgccg 3771781 gaactgaaag cagacgaagt cctgcaaaaa cgtctctaca gcctgcctaa cgttactgtc 3771841 gtgaaaaacg cacaaacaaa agaaatcaca ggtgatcaga gtgttaacgg catcacatat 3771901 gtagaccgcg aaacaggcga agaaaaacac gttgaacttc aaggtgtatt cgtccaaatc 3771961 ggtctcgtgc caaacacaga atggttagaa ggaacggttg aacgcaaccg catgggcgaa 3772021 attattgtcg acaaacacgg cgcaacaagc gtaccaggct tatttgctgc cggcgactgc 3772081 acagacagtg cgtacaacca aattattatt tctatgggat caggtgcaac tgccgccctc 3772141 ggcgcgtttg attacctaat ccgtaactaa tataagaaat ccgctatatt gccagattgg 3772201 caggatagcg gatttttctt tttctacaga aaaaaaccga accaggcact acggtaaaag 3772261 tgctcgattc gagcgcttct tatagttcct caccattcgt ttgaatgaca tttttatacc 3772321 actcaaagga gtctttctta tatcgtttca tggatccgtt tccttcattg tcacgatcaa 3772381 catagatcat gccgtagcgt tttttcattt cgccagttgt gaaggagaca atatcaataa 3772441 tgccccacgg cgtgtagcca attaaatcaa caccatcgta cgtgaccgct tttttcaatg 3772501 cttcaatatg cgattttaaa tattgaatgc gttccggatc atgaaccttg ccgtcctcct 3772561 ccagcgtatc cactgcgcca aagccatttt caacgatgaa taacgggatt tggtatcggt 3772621 cataaaaacg atttaacgta tatctcaacc cggttggatc aatcgcccat ccccagtcac 3772681 tcgaagtgat gtacggattt tcgacaccat tcggcaagcc gccatttaca atatcgccag 3772741 tgttatcatt tttcacatcg cttttcacag ttgttgacat gtaatagctg aagcctaagt 3772801 aatcgacggt tccgtttctt aaaatctcat catcgccgtc ttcgaatgtg atgttgtagc 3772861 cttcgcgttc aaattccttc aacgcgtagc ttggataata accgcgaacc tgcacatcag 3772921 ggaagaaata gcgctgcctc atttcttctt cagccagcat cacatcttca ggattggagg 3772981 agaaaggata aatcggcacg tgtgatacca tggccccaat ctggaactct ggattgatgt 3773041 cttttccttt tgccactgct aaggcgctcg ccactaattc atggtgcgcc gtttgataca 3773101 tgacttcctt ggcgttttcg ttttcgccaa ccacaacacc tgaattcgtc cataggaaca 3773161 gcggattgtt cacatccatt tggttgttaa tctcgttaaa tgtcatccag tacttcactt 3773221 tatctttgta acgggtaaag caagcctctg cgaagttgac gaagaagtcc acgactttcc 3773281 ggtttctgaa gccgccatat tctcttgcca ggtgcagcgg catttcaaag tgagacaggg 3773341 taatgaccgg ctcgatccca tgcttcagca attcatcaaa cacatcatca taaaactgca 3773401 aaccagcttc gttcggttca gcctcatcgc ctttcggaaa aatccggctc cagccgatgg 3773461 acgtccgcag acattttaat cccatttccg caaacaaagc gatatcttcc ttgtatctgt 3773521 gatagaaatc aatggcttca tggtttggat aaaattcgtt ttcttcaatc gtgtcagtga 3773581 tttttctcgg cacgccgtgc gcacccgctg tcatcacatc gacgacactc ggccctttac 3773641 cgccttgatt ccatccgcct tcaaattggt gggcagctaa agcaccgccc cataaaaaat 3773701 cctttggcat gtttcccatg tttaattcct cctcagctta cgactgtaaa tattttttga 3773761 tgtaatgcac tttcctcaat gtcttcaatg aaagctttat caaactcaac aagcacttcg 3773821 ccttttttga cggtatcgcc ttcttttacc ttcaaggaaa aaggcgtgcc gtcaaatgtc 3773881 accgtatcca gcccgatgtg cgcaagcaat tcgacgccgg acgctgaacg caggccaatc 3773941 gcatgctttg taggcgtaac catgacaacc gtaatgacgc cgggatggta gcatcgattt 3774001 cacgatatcc ttcgctttag gggtagaccg cttcagcacc aatcgaagtc tggtagcgca 3774061 gcgagaagcc ccaatcacat tctcttcccc gcctacggcc tctaaaatgt cttttgctag 3774121 tctcgtataa tctctcactt tccccgacat ttcacccacc ccttcgtttt ggttacgctt 3774181 tcattataat tgtaacggta taatttatca attccgaaac aaaatattta cgcactaact 3774241 atcattgtaa gcggtttatg ctataatttt gacaagtgaa actaaacgaa taaatgagga 3774301 atgcgtatgt taaaatacca gcaaatcgca acggaaattg aaacatatat agaagaacac 3774361 cagcttcagc agggagacaa actgccagtc ctagaaaccc tcatggccca gtttgaagtc 3774421 agcaaaagca ccatcacaaa gtccctcgag ctattagagc aaaaaggcgc gatctttcag 3774481 gtcagaggaa gcggcatttt cgtcagaaaa cataaacgaa aaggctatat cagccttctg 3774541 tcgaatcagg gatttaaaaa agatctcgag gatttcaacg tcacctcaaa agtcatcgaa 3774601 ctggacgtga gaaagccaac accggaagcg gcggaaaacc tgaacatcgg aatggacgag 3774661 gacatctact atgtcaaaag ggtccgctac atcaacggcc agaccctttg ctacgaagaa 3774721 tcctattaca ccaaatccat cgtgacgtat ttaaacaacg aaatcgtctc ccactccatc 3774781 ttccattaca tccgggaagg actggggttg aagattggtt tttctgattt gtttctgcac 3774841 gtgggccagc ttaatgagga agaagcggaa tatttgggat tagaggctgg actgccgaag 3774901 ctgtatatag aaagtatttt tcacctgaca aatgggcagc cgtttgatta ctcgaagatt 3774961 tcgtataatt atgagcagtc gcagtttgtg gtacaggcta atagtttttt attatagggc 3775021 tcttcactac ggtaggtggt cgacatgtac aaaattatca ttcctgccat actagccatc 3775081 tttgcgctct ggatactctt acagatttca ctagagatga gcatcgttaa gaatccaatg 3775141 aactacttta tcgtattcat tatctttttc ctctttgtaa agatggtgaa agaaaaacaa 3775201 taatagtttg ggcgatgcaa acagaaaaac atccttccct taacaaactc agccagtcac 3775261 atgcattaat cttgatgtta atgatatata ggtgcacata aaaagctact tcattgtgaa 3775321 gtagctccct ttattaaagg cccattttga tccatctagt tttagaaaag cgaaggacaa 3775381 tcgcatttat gataataatt gaaactaaat acaaaataat aaataaaaca tcattactcc 3775441 caagtgtcat gttatcagat tgcagcactc tttctattcg ggggtacata gtgttacctg 3775501 cctcaaaagg agcaatgaaa ccaaacgttt tattgcttat agctactaag ataacagaag 3775561 tcatccaata aacgatactg acacctatac taattaatat attaggacat aacacgctta 3775621 tagttccgat aattagaata tactgcagta taactgcaga aaataaaaaa agtaataatg 3775681 caaaatgcga aaaatcatgg tacatcaacg atatgattag caggcctagc gttataaatg 3775741 caaaacattc taaaaataaa acagctatct ttttataaaa gaaagtatag atgttctctc 3775801 caattaactt gtaaaagaga atatttttgt ttgaatactc tctattaata aagaaagcta 3775861 taacaaatga aaataacatc aaaccaaact gggtcgcaac agtataggag ctaaagaaaa 3775921 acatttcagg tgtaacatta ctgactttat cgattccaac aagtaaaaaa taacccagca 3775981 aaaataaaaa tacaaacatt gctcctaaaa taatgataac tttgttgcta atactctttt 3776041 taaactctaa tttcatctca agcccccact gttttattac tcatttatat acacttcaat 3776101 taatttatcc actgaatgat attgttgaat ttcttggtga ttaaatatat aataatcccc 3776161 ttctatcgcc tttaaatcag acaaatcatg tgtaatgttg atgataatct tctcggggtt 3776221 ctcctgaata tacttgttta agaagccatg aatctctata accgtttttt tgtctaatga 3776281 attcgttatt tcatctaaaa caataatatt tttatcctct aataagaaac tgagcaattt 3776341 taatttttgc ttttgtccat cactcaaatt tttgatcaga acttttccat caatattatc 3776401 cagattaagt aaatatgcga ttttatctat catttttgca tcaaattttt tactcaaaaa 3776461 gtgtaataaa aagtccttag aaacatcatt aggtatattc gacgagctgg atattaaaga 3776521 aacattttga cgaatatctc tgccgattct tttgctatta ttcaacaaaa agtctttagc 3776581 aagctgtgat ttaccgactc cattttttcc gacaacgtga ttaattttcc cgctcgaaaa 3776641 atgcaagtcg gtgtcctgaa gtaacgtttt gcctttcact tttaaagtgt aattcgctat 3776701 attcatatac atactcctag gaaatatttg cataataata aaatgttctg ccttgtgatt 3776761 tgttactaat gtctaagctt ttgaggtacc tctttcgttt ccgatccgga agcgaaagaa 3776821 atgtttttag atggctaatt tggagatctt ttactctagt ttacaatata taatatccaa 3776881 tgtacaactg aattcactgc aaggccaatc cctataattt gaatcgtaag aactaaccaa 3776941 tgatttgtct taaaacggct atattcatct aagctcagaa aagctaaaag aattttgtaa 3777001 ccatcagaat tcaatattgg gattaagttc cacaataaag tagacgagaa aagcataaat 3777061 gccatagtta atgcttcact ggaaaatgta aattgattta ttaattctaa tgtatttatt 3777121 aaaagataat tgataaacaa gccaaataaa tgaacgatta tcttttcatt tcttgatagc 3777181 atgtaggttt cattcaattg gacataaaaa gcaggaaata cataaaaatt cagtttgaat 3777241 cccactttat caaagttttt cccgaaaaat tttaaggaat aaatatgtcc cagttcatga 3777301 agcactatat tcattataaa ataaataact ataattatcc acattttcca gccgtaaaat 3777361 actgaggaca atccattttg caattttatt aaatgaatat aatttaatat gaacatgaga 3777421 gccgtaaagg ataagaacag ataaaaaaac tttggtgata ctttctcttt atacatttta 3777481 aaacgtaata attgtttatc tgacagagaa tttaaactat ttttatagta ttctccgctt 3777541 tttttgtctt ttataaatac gttgttttgc acaagcactt catatttttc atcttcatac 3777601 tttaaaattt tcattatagt atttttccat ataaggatag aagtagttta ttttttctgc 3777661 agagttgaat aaggaaccac aaactccaca aatagaggaa aattcataag gaatgtcaaa 3777721 ttcctctatt ttgttatttt cttttaaaat attcaaaaac catttgaatc cttcttttct 3777781 aagaataaat aatagcaaat tggaatttaa cttttccacg gttctttcga aactttggtt 3777841 atattcttcc cttagggtta ttttcgtttc aaaaatagca ggggaacaac atggataaat 3777901 ttctccatca tgatgatata caatgtcata tccgggacaa tgtaaggaat cttcatcttc 3777961 aagactgtaa aatttatgta tgttttcttg cttaattcta gttttagcag cgccaactga 3778021 tatcattgga aattttgtta tctttacacc taagattgaa tcccccaatt cctctaaaat 3778081 gtggttggac attttgtctt tggtaactgc catattaaga gaaatatcga tatcagggta 3778141 tttcctgcta tgttctaata tgtttttaat actggaagac ttgacaaatg gagcatggta 3778201 ctcatcataa cttatagtca gtgctatcac atttaaagaa ttcatatcat gaaagtactc 3778261 ctggaccttt ttcttgctca aaccccaaaa tccattagag atcaacgtta tttgtttttc 3778321 atatggttta atgatttcca ttagttcttt taaaaattta taatctaaaa aaacttcccc 3778381 acctgtaaaa gaaatcactt gaatggtttt gttttttgca aattcagtta ctaactctct 3778441 tatgtattct ttttccatcc tggttgttga agttggtgaa ctagaaaaac aacaatggtc 3778501 acaggatgca ttacaccttg aatctaaatt gattgatact gttttattat acatgaaata 3778561 tcccccaaca aatggtaaag gagagttaga ctctcctttg tacccctcta attaatgacc 3778621 acttccaaga atccagcgat tttcttttga ttttacaaaa taccaaagat cattcacttt 3778681 tgctaacttt tgtgattcat ctaatagacc cttaaattct aagtttttca cagtctcatt 3778741 gttagtgatt tcctttttca tattatccct cctccttttc taatataaac caattattct 3778801 atatcattca atacatgtca atatattgta cctaaaaaat ctgaaaaatg tcactattct 3778861 tggtatataa agcctatagt cctctagccc ctctaagcta taccgaatga aaggccatag 3778921 tttgatttaa agcttcgtaa tgaaaagtaa aacatcaata ttgactacac tagttaaggg 3778981 atatacagat tttaagtgga agaaatgagg caaacaatct taccctaaac caacctgtac 3779041 tgaaaagctg ttttaagctc ttgcttaccc catttggcac ctctttctct cgttttaatt 3779101 gtctctaaaa gcagttatgc ggtactatca tataaaggtc caatgtttaa aaataatgtc 3779161 atacttttaa attcacctta tcatgcacat gctcataaag aggggtttat tctaaaaagg 3779221 ggatggacgg ttttggaaag caagtaccta gatctactcg cacaaaaata cgattgtgaa 3779281 gaaaaagtgg taacagaaat catcaatttg aaagcgatat tgaacctgcc aaaaggcacc 3779341 gagcattttg tcagtgatct gcacggagag tatcaggcat tccagcacgt gttgcgcaat 3779401 ggttcaggac gagtcaaaga gaagatacgc gacatcttca gcggtgtcat ttacgataga 3779461 gaaattgatg aattagcagc attggtctat tatccggaag acaaactgaa attaatcaaa 3779521 catgactttg atgcgaaaga agcgttaaac gagtggtata aagaaacgat tcatcgaatg 3779581 attaagctcg tttcatattg ctcctctaag tatacccgct ccaaattacg caaagcactg 3779641 cctgcccaat ttgcttatat tacggaggag ctgttataca aaacagaaca agctggcaac 3779701 aaggagcaat attactccga aatcattgat cagatcattg aacttggcca agccgataag 3779761 ctgatcaccg gccttgctta cagcgttcag cgattggtgg tcgaccatct gcatgtggtc 3779821 ggcgatattt atgaccgcgg cccgcagccg gatagaatta tggaagaact gatcaactat 3779881 cattctgtcg atattcagtg gggaaatcac gatgtccttt ggatcggcgc ctattccggt 3779941 tccaaagtgt gcctggccaa tattatccgc atctgtgccc gctacgacaa cctggatatt 3780001 attgaggacg tgtacggcat caacctgaga ccgctgctga acctggccga aaaatattat 3780061 gatgataatc cagcgttccg tccaaaagca gacgaaaaca ggccagagga tgagattaag 3780121 caaatcacaa aaatccatca agcgattgcc atgatccaat tcaagcttga gagcccgatt 3780181 atcaagagac ggccgaactt taatatggaa gagcggctgt tattagagaa aatagactat 3780241 gacaaaaatg aaatcacgct gaacggaaaa acatatcaac tggaaaacac ctgctttgcg 3780301 acgattaatc cggagcagcc agatcagcta ttagaagaag aagcagaagt catagacaag 3780361 ctgctattct ctgtccagca ttccgaaaag ctgggccgcc atatgaattt tatgatgaaa 3780421 aaaggcagcc tttatttaaa atataacggc aacctgttga ttcacggctg tattccagtt 3780481 gatgaaaacg gcaatatgga aacgatgatg attgaggata aaccgtatgc gggccgtgag 3780541 ctgctcgatg tatttgaacg attcttgcgg gaagcctttg cccacccgga agaaaccgat 3780601 gacctggcga cagatatggc ttggtattta tggacaggcg aatactcctc cctcttcgga 3780661 aaacgcgcca tgacgacatt tgagcgctat ttcatcaaag agaaggaaac gcataaagag 3780721 aagaaaaacc cgtattatta tttacgagaa gacgaggcaa cctgccgaaa catcctggca 3780781 gaattcggcc tcaatccaga tcacggccat atcatcaacg gccatacacc tgtaaaagaa 3780841 atcgaaggag aagacccaat caaagcaaac ggaaaaatga tcgtcatcga cggcggcttc 3780901 tccaaagcct accaatccac aacaggcatc gccggctaca cgctgctata caactcctac 3780961 ggcatgcagc tcgtcgccca taaacacttc aattccaagg cagaagtcct aagcaccgga 3781021 accgacgtct taacggtcaa acgattagtg gacaaagagc ttgagcggaa gaaagtgaag 3781081 gaaacgaatg tgggtgagga attgttgcag gaagttgcga ttttagagag tttgcgggag 3781141 tatcggtata tgaagtgagg ggtgtggggt tcagggatgg tgatatgctg ctcccctaaa 3781201 agtagataga tgaattttag aaaatctgtt tgccttgggg agttttttca tggctggaca 3781261 attatactac aaggaagaaa tactaatact tatagaatgt aattgggtaa tgattcggag 3781321 aaagaggttg cgaaataata tggtattaca ctgaaacaat tatcaatgga gaacatgcac 3781381 gatatagccg ttctatattc tccctctatt atggcactca ttagtagaca taaccgtaaa 3781441 aaaatgcact caaaaaaagt ccattctata taactctcgc tagggtggac ctttttcaac 3781501 attcaaagta ctagattttt tctagtgaaa gaataagaaa agacataagt tctattttat 3781561 cactctgtta taggttaagt tattacggtg tttcattata tactgaattt aaacaccctt 3781621 gacattatgg gaatttttaa aacaggttaa aaggaagttc tataagaact ccctagttta 3781681 atattatttg gtcaaaatct aaaaccaaaa aatctatttt tatcttcatt gtttctatct 3781741 aattttgcaa caatcatacc tttcgactct aattcttgaa ggtcatctaa taataattca 3781801 tttttattta ttgttacaaa atattgtccg atcctattct ctaacagact tgaattgata 3781861 tgttttaata atgtaccttt tacatgagga tcaggattag aataagatcc gtcatgaatt 3781921 aaaatattca aactacactt atttatacac ctgtataaaa accaagtaag atcaaatata 3781981 tttatcttca tatggagtct accatgtgaa cgttcatccg gtatagaaca agaaattttg 3782041 atccttcctg tagttgattg ttttgcgtta cttattctat tatcatattc aaaatctaaa 3782101 aatccatgtt ggttgtatgt aacatccatt agattattaa aaagcttctt taactcacta 3782161 actatagcgc tataagattg aaactcatca taatacattg aattaactct taatatttca 3782221 tgttgaagtt cattaatctt atcaaaaata tggttttttt tatcgtagtc actaattctc 3782281 aatcttactt ccgctaactc tatttctttc cttctttgtt cttccatcac aatggaaata 3782341 tcctcaatga aattgttact ctttaaaatt ctggcacttg attccagttg ttctgttaat 3782401 ccttgctttt tgatattaag tttttttaaa tcggcttgta ttttaacaat tttatcttta 3782461 aaataactcc ctctactttc taccatgaaa ttatagaact cttggacttt attataattc 3782521 tgttttactt cctctggaaa aaaacctaca atatcttcat agaatttttc tatattttct 3782581 aattctttaa tcttagttac ttttttattt aaatcatcta tatttctttg atattgttta 3782641 caaatatgtt cattttcaaa tatttcattt tgtattttat taagttcact tttaatttct 3782701 gagtacctat ttgtatcatt attatattta ttggcagtct tagtttgata gataactcta 3782761 ttgtaatcct ctatctcatt tattaattca tcttccttaa cttttaaatc gccaatgtta 3782821 atattcattg attcaatcaa ttttatttca ctatttaatt tttcaatctt atcccgaaaa 3782881 acctttatgt ttttttctgt atgagttggt aaagtaaaaa gatagttaag taatttatat 3782941 tgttttaacc ctcccctatt cggtaaaact atatcattaa accctgtctt ttcgtctctt 3783001 ataatatact cccttaacgc cgcaaaagtt atatcctctt tctcaccctt taaaatttcc 3783061 ttttcaataa attttttata tacacttata ctaacttttt tccattcctc caaattaaaa 3783121 gttaaagaag tatcatgtaa tgtataacca tgtttaggag aattaaaaga tctagcaagg 3783181 aatacttgat ttccatcaat ttccacattc aaaacaataa aaacgttttt attgagaaga 3783241 atttcatttg tcgtataaaa atttgatata gtcttcccta gtaaaaagga gatgcattca 3783301 atcatcgttg acttacctac accattagtc tcttcatgat cttctctctt ttcaccaagt 3783361 attatattta ctcctacagc attaaattta tactctttca aaatttcttg ggaattgcaa 3783421 acaaaaagat tttttataat cataacaatc actaactctc cgttctgcta atcatatttt 3783481 gattaaaaga aactttacct aatgaatata aaaaagttaa cgataaatac agtatccgtt 3783541 caatattcaa atttattata ataccttgac tcttagcata atcaagaaaa agttgatcaa 3783601 tatgtttttc cttctctaac agttcataaa gtatctttga tgagtataaa atattttctt 3783661 ccacagcatt atatttagtt aataaaaaat gattcatttc tggcctctcc gccttttcct 3783721 tttttaaagg agaattattc actagaggaa taagatcatt tccaatttga atgtttttaa 3783781 actcattttc taataaaaca taagagtatt tgagaatatt ttcagctgtt tcaattttaa 3783841 gatcaatcat tcttaacact tcttttgtta tcattaaaaa tctcacattc ataaatgcac 3783901 caacatgtta aaatcttaat gtattttttc gttaaagcct ttgaatatgg taaaactgaa 3783961 tgacattcta gataaatctc attaacaatt tttacaaata tctcatctcc attattatat 3784021 tgattatgaa actctagata tttgtctact atcgtctcag caatcaattc ctttttatca 3784081 gcacttacat acgaagtgga atccattata tggtttatca caccaaaata ctcagaataa 3784141 ctatcgaatt tccgtttaaa agtttcccca cttttcatat cataaaattt tttatctaaa 3784201 ccaatttgat tatcaaaatt actagtaaat gttttataac tttctctata ctcatgaaaa 3784261 tctataataa agctcttaaa ctcatcttca tcaattttat catcgttatc ttctatttct 3784321 ttttcaataa ggctctctaa tctattaatc ttataattta acttcccttc ctgtagtctc 3784381 cttcctcctt ggttgttttt tgaccagtat ttatattcgg tattccaaat gtagtatgtt 3784441 acttctgtct cgccattatc taaattcaca tccaccgaaa taaattctgg agtagcatac 3784501 tcatccttta taatggctcc acttactaat tctaagaatg gattttcatt tgtatttgca 3784561 gtaatattaa atgaagaatc atgtacatgt cctgccaaat atagatcaat aaagtaatca 3784621 tcaaaatgtg cctttattga ttctctttcg gaagattcaa tacaacctaa cgtatggtgc 3784681 ccaatagcta tatttaatac cttgccctta tttttctctt tgttcatctt ccttattgct 3784741 ttatataatt tcatctgtgc agttaataac gttccttctt cacctttttt atctgataac 3784801 agacatgtat ttattgataa aacattatac ttctccgatt gatacaaaaa atgcaaatct 3784861 tcttccggat atttaacacc cataaaatct tcataaaaat cgaaaaattt cctttgacct 3784921 tccactaata tatttgtagc tttttgatct agtttatcca acatttctga ggggttagga 3784981 gatttcataa tactatcaat caaaagtgtc ctcgtcatgt ctctagatat atcgtgattt 3785041 cctggcacta agtgtacgtt attcttactt aatcccatac ttttaataat tccattaaga 3785101 tattctttaa catcttcgtt atacacatca cctttgtgtg ctatatctcc agttaataat 3785161 aaaaaatcaa aatctgactc tcttcttaaa acttctataa aatctaataa tttatctctc 3785221 attacaatag tgtcataatt ttgaaactga aaatgcaaat cagaaatttg taaaaaacgt 3785281 accttcaata caaacatcct ctcataagta tatttatccc ctatatattt ctagaaaact 3785341 ttttattcta tatcatcttt actctttaat atattaagac tctttccaca ccatcaaata 3785401 aattataacc taaacataac tctttactca ttttagtatt gtatttaagt caaacattgc 3785461 attggttgct gaaatattat attcattgaa ttattccatt aaatagcttt tagttgaact 3785521 ttagtctttc tgtaatggtg gagatgctct tacttatgat aaggctcccc acgattaatc 3785581 cgaaaagccc gataaatctg ctccactaaa ataagccgca tcaactgatg aggaaatgtc 3785641 atcttcgaga acgatagctt ctcgtccgct cgcttcatca ccgtgtcact caatccgagt 3785701 gatccgccga tgacgaaggt gactttgctt tttccataag tagccagctt atctattgta 3785761 tcggctagtt cttcggatgt tttcattttt ccttcgatgg cgagggcgat gacgtgggcg 3785821 tcggggctga ttttggatag gatgcggtcg ccttctttgt cttttatgat tttcatgtcc 3785881 tggtcgctta ggttttccgg cgctttttcg tccgggagtt cgatgatgtc gatttttgcg 3785941 taggccgaaa gtcgtttggt gtattcttca atgccttgct tgaggtattt ttcttttagt 3786001 tttccgattg tcacaatatt gatattcaca ggtcatcccc actttaaaaa caagttattc 3786061 atatatgttg tccacaattg tggatatctt ttctgtattt tgtgtaagat cattcgttcc 3786121 ccactatata tactgcgggg tctccacata attcacaggc tgtggataaa ctgttagtat 3786181 gttcgatttt tctgatttcg ggcggcagct cgtggtcgtc tatgtacata tccagcaccg 3786241 tttcgatgtg ttcttcacaa gaataatacg cttgtttcat gttcaaatcc tccgatgttt 3786301 tcttccattt ttacaaatgt tctcttctca atataaccta tttattcaca tgttagtagt 3786361 gcttcgggct gagttttatc cacaattcga caaacaagct gttgatgact ctatttcgct 3786421 cgtgtgttag tttggatgta accgatgtgt ggggaggtct gcatttgcgc tttagatggg 3786481 tttggctttt tgtgattatg ttgctgcttg ctgagtgtca gccatcttat tgggtgttgg 3786541 agaaggatcg aatcggtgaa ggcagtccag acttagaaat atacgctaat tatctccaaa 3786601 tgcatgatga cgtgaaagga tatcaagtct tcaccatatc agaaggcaaa aaaatggtcg 3786661 tcgtgtctct cggaagcagc gagaaagata agaagcttga agtgtcggac gtcaaattct 3786721 catctaaaga aacgattgta actgtggagc gaaaacctgc tcctacggca aatgagaaaa 3786781 acccttttat tttgattgga ctggacaaaa ttgaagggga tttaattgtt caagacgaaa 3786841 caggagatcg ctttgaagaa acggattacc agcaataaag ccggcgttct gagaacgtcc 3786901 ggctttttct tttacttcaa tgtcccatgc gggtcgatga cgaatttttt ggctgcgcct 3786961 ttgtcgaagt cgctgtagcc ttttggcgcg tcgtccagag aaataacggt ggcattgacg 3787021 gcttttgcga tctgcgctct gccgctcagg atcgctttca tcaaattgcg gttgtatgtc 3787081 atggcgggcg tttgtccggt gacgaaggtg tgggctttgg cccagccgag tccgaagcgg 3787141 atttttaatg agcctgtttt ggcgtccgca tcctttgcac cgggatcttc ggtcacgtat 3787201 aagcctggaa tgccaaggct gcctccgacc tgggtgacgt ccatgattga gttcagcacg 3787261 gcggctggcg cttctccttg attgccgtgc ccagatgctt caaagccgac acagtccact 3787321 gcagcatcaa cggttggttc acctagtatt tgttcaattt gctcgccgag gcggtcgtgt 3787381 ttttgcacgt tgaccgtttc acagccgaag cttctggcct gtgccagcct gtcttcgttc 3787441 agatcgccga caatcacggt agaggcgcct aggagctgag cggagtgtgc agctgccaag 3787501 ccgacaggac ccgctccagc gatataaacg gttgaacctg tttgcacgcc cgctgtataa 3787561 gctccatgga agccggtcgg aaaaatgtcg gacagcatgg tcaaatcgag aatcttttct 3787621 agcgcctgtt ctttatcagg gaataccaaa agctgaaaat cagcgtatgg caccatgaca 3787681 tattcagact ggccgccgac ccagccgccc atatcgacgt agccgtaagc cgatcccggc 3787741 cggtccggat tgacattcag gcacacatgc gttttctgcg ttttgcacat cacacagcgt 3787801 ccgcaggcaa tattgaaagg aacggatacg atatctcctt ttttgataaa ttcaacatca 3787861 cgccccgttt caatgacttc tcccgtaatt tcatgcccga gcaccaagcc ttctggcgcc 3787921 gttgtgcggc ctctgaccat atgctggtcg cttccgcaaa tgttggttgt aatgactttg 3787981 agaataaccc catgctcaca ttttcgattc acattcgcct tcgggacgcc gggcccgtcc 3788041 ctcaagatta actccggata accgatatcc tccaccgcta cagtcccttt gcctttgtac 3788101 acaaccgctt tgtttcctgt caacgccatt cctcccattc atgtgtttgg actctccgtc 3788161 cttgaacatg acttcggttc ggcatgactc tttccctttt tcacgactgt tttttctgta 3788221 ttcttacaac aacaaatatg ccaagaaagc atccaataat ggttccgccg atgtctaaga 3788281 agtcgacttt acatccattt aacaagaaca cagtaatggc cgaaaccagg cagatcataa 3788341 ctgccagaag aataacccga tttgtctgca tgtaattcct cctttggatt cgtttctaaa 3788401 ccatacccaa aatcctctgc aaacttcggt tcaacaaaaa aagagacttc acaccagtct 3788461 cttcataaac agagatcact caaaaaattt cctgagaaat aatgtggcaa cactcgttac 3788521 taacgcaatt gccgtataca taacaaccca aaatatgaat gagctattcc ccgaagctaa 3788581 cgtaactaac aatatcaagc tcgtgataag aacgatgagc ggtgccaccc aaaatctttt 3788641 aaataaaaaa tgacccgcta taccaaatac acctgcgacg atcggaaaac caaaaacgat 3788701 aaataaaacg gcgatggctc ccatactacc ctccttgcct taaaacctct tcatcacctc 3788761 aacatcatac agcttcaaat gactcttcgg cgtcacgaca tcctttacct tcccaatctc 3788821 tttttctttc attttctttc cggttttcag gctgtactgt tcaatgtagg caggcttgtg 3788881 atacgtgtat gtgaagaaat agaggctgct gcctttttgg gtgatttctt tgaattcggc 3788941 tttcattttg tccggggaaa gggtgaagac gatgcttgtt tttcctgtct tggcatcgat 3789001 tttgtgtacc tttccgaagc cgtcaatgaa atacaggttc ccgtcataag ggaaaaagct 3789061 gtttttaaag ctgaagggca tggagctgta tatcgtttgt tcgtcgtttt tgtattcggc 3789121 gatatcgtgc agctctactt cgccgctttt tttgttgatc ttgaccattt gatagagatc 3789181 gtgggctttt tggccgcgaa ccataacata cacagcttgg tcgtccacgg caagttggga 3789241 ttcgactgag gctccttccc ggtactgcca ttccgttatg ctgagatagg taagcttctt 3789301 ctgatctgct tgaatctgaa ggagctgata gccttttccg tcatctgtcg ggacgagtgc 3789361 gtaaatggcg ccatcatgga aaccggaggc tcggatgtag taggggatga cgtctttttt 3789421 ccactctccg tccatttggc ggtacagctc tgagcggtat ccgtctccct ttttgtcgta 3789481 gccggagttg tataaggtgt aaaagccgtc cgtgttttgc agaaagcccg cgctgtcgcc 3789541 tgtgtgctga taggttcttt tatgggagcg caggccgttt ttgatcgtat aaatcgtgtt 3789601 tttgtcctcc agcatcacgc tgtcaccgtg aacctttgct gagcccagct caaggccctt 3789661 catctgaaag gaagacagcg tcccgtcatg gctgataaac agggcgtagc ttttcccgcc 3789721 gccaaatgca tcttgatccg cagaggatga gaaatacagc aggacttctt tgtcatccag 3789781 gaaatcggga tttctgagat cctgctgact cacggtttta tggcttttga gaggagaaat 3789841 gaagacaaat agtgcgattc ctgcgagaat cagcatggcg atggtaatca tccacttttt 3789901 catagccttc tccttagtaa atggtcataa tggttgtcgt ataagaagaa ctagtgatgt 3789961 cgcgcggata cacgcctaag cctccgttgc tgtctatatc aatccctgct ttcagcaaaa 3790021 aggcagacca taggagcttt gaacagtttt tggcgccgtc atggccggta tttctgttat 3790081 tgacgaagtt aaatgagtat gggtcgccga cttttgatac cgcccagtcg gcagcagctg 3790141 ttttttgaga tgaggatacg ctgacggttt gcacaatgga gttgtcttcc acgtctctgg 3790201 cattatacgc gatctgcctg acgccgtcgc tcgggacaga ttcaacaatt ttgtcagcgg 3790261 cggagtacat gccgacatgg ccgtgattgt agtaggctgt gtaggagttc gtgtaataga 3790321 tattgccttt cgcgcttgtc gggagttttt tcgtgccgga cgagccgccc atgatagaca 3790381 tgccgctttc cttggcgagc cggtccccct ctgctttatc agccgtgatc tccttataga 3790441 actgttttag gataacgtcc tgctttacgt gctgctgttt ggcaatctgg ctggcagatt 3790501 tcatgatttc ttccggtgtc gtgcctggct gcagtgcggc gatttcttca gcataatttg 3790561 tggtctttac ggctttggcg ggagtaacaa acaggccgcc gcacattgtg agcgctacca 3790621 aaaacatcga cactcgtttc ttcaacttca ttacatctcc tcttttcttg tgagtgtagg 3790681 aaaggtaatt tcctcaccca cattatatta ggaaaataag gaaagtaact aggttattta 3790741 cagaattttt agaaatcgtt tacagaaaaa ggcctttatc aggccctttt cgttaaagct 3790801 tcttgctcat cactacgtct gtttcttgaa atccggtttg ctcatatagc tttcgagccg 3790861 tctgattatg ggcaaagaca tgaagggaca gcttgcggat tcccatactg cgtgccgctt 3790921 gatctaatgc cgccaatgct tgctttgcgt agccctttcc ccgatacggt tcatataacc 3790981 cgaaatcata aataaacgct tcctgctgcg gatgctccgg ttcagcatgt atccagagcc 3791041 agccaacgat atccttttca ttcagcttga ggctccacaa atggtgatgg ggtgtttcga 3791101 gccctctcgg aagcagatca gtaaacacct gcttagacaa aagctgggca tcttcaggca 3791161 gccatgttcc cgcttttacc ttttcttccg cgtaatgctt tgttgtgtac gtgagataag 3791221 accgaaattc ttctgtctgc ataggggtta gcataattgt catatcatct ctccttcata 3791281 tattgactag aggattttac ataaaataga aagaggtgtt actatcagaa taagcaactg 3791341 agattgataa gtcactagag aaaggagttt cacatgaata agatcgcacc cgcagaaatc 3791401 gctagcatgc tcaacgattg gtaccttgcc atcaagaaac atgaagttga agaatcctcc 3791461 cgtttatttg aagaagtgaa gcctttattg gatgacatgg aagaggatca ggaggtgctt 3791521 gcctacttct ccttattgga actgcgccac aaggttttgc ttcacgaggc gagaggacag 3791581 ggctttcagc atgaggagcc ttctcatatg aatgctacgt ctgacatgct gaaatattac 3791641 ttttttctgt ttgaaggcat gtatgaggcc tataaaaata attatgacat tgccattggg 3791701 ctgtataaag atgcagagca gtatctcgac aacattcccg atccgattga aaaagccgaa 3791761 tttcacctga aggtcggtaa gctctattat aagctgggac aaaatattgt gtccctcaat 3791821 catacacggc aagcagtcaa aacattcaga gaagagacag attataaaaa gaagctggct 3791881 tcagccctga ttaccatgtc aggcaatttt acagagatga gccagtttga agaagctgag 3791941 gcttatttgg acgaagcaat tcggatcacg agtgaattag aggatcattt ttttgaagcc 3792001 cagcttttgc ataacttcgg ccttctacat gcgcaaagcg gcaaatcaga agaagcggtt 3792061 tcgaaattag aggaggctct acagaacgat gagtatgccc gctccgccta ttattatcat 3792121 tctgcctact tgctgatacg agagctgttt aagatcaaaa agaaagaaca ggccttatct 3792181 tattaccaag acgtgaagga aaaattgact gctgagccga atagaatatg tgaggcaaaa 3792241 atagacattt tatatgccat ttatgcagaa gggggtcatg cggaaacgtt tcacttatgc 3792301 aaacaacata tggatgactt gttgtccgag aaagagtatg acagtgtaag agaactttcc 3792361 attttggctg gcgaacggta tagggaactt gagctttaca aagaagctgc ccactttttt 3792421 tatgaagcat tacagattga agaactgatt aaacgaacgg aggttatata aatgaaaaga 3792481 tttctgattg gcgcaggcgt cgcagcggtg attttatcag gttggtttat tgcggaccat 3792541 caaacccact cacaggaaat gaaagtcgct gagaaaatga ttggataaat gaaaaacccc 3792601 cgcgggatgc gggggttcaa tttaacgaaa gaatcctaaa acggtttgta gttttaggat 3792661 tctttcatct tttcagcgtg attgaaaacc cttgaagtct aggaagaacg agcattggag 3792721 cgcagcgaat gtttggaatt cgtgagcacc gaagcgcagg cctgacaacg aatgcgaggg 3792781 tttgtcgaca cgctgaaacc cccgcgggtg cgggggtttt cttattacag cagcttcttc 3792841 cctaacaggg attctacgag ctctactgct gttttgcccg ttttgttttt gtgatcaagg 3792901 atcgggttaa cctcaacgaa ttcggctgag gtaatgatgc ctgcgtcata cagcatttcc 3792961 atagccaaat ggctctcccg gtagctgatg ccgccgacga caggggttcc gacacccggt 3793021 gcgtcgttcg gatcaagtcc gtccagatca aggctcagat ggacgccatc acatgctgat 3793081 aaataatcaa gggtttcttc aatgaccttt gtcatgccaa gacgatcgat ttcgtgcatt 3793141 gtgtacacct tcatgccgct ttccttaatg tacttgcgct ccccttcatc aagtgaccgg 3793201 gcgccaatga tgacgacgtt ttccggtttg attttaggcg cgtagccttc aaggttaacc 3793261 agtgactcgt ggccaatgcc taggctgacc gcgagcggca tgccgtgaat attgcccgat 3793321 ggtgaagttt caagtgtatt caaatcgccg tgcgcgtcat accagatgac gccgagatta 3793381 tcgtaatgct tcgctgtgcc tgcaagcgtg ccgatcgcaa tactgtggtc accgcccagg 3793441 acaagcggga attttttctc ttcaatgact ttgttgacct tttgcgcgag tttttcattt 3793501 cccgccaaaa cggaattcag gtttttcagt tcctcgtcat ttttgatttt ttcgcgattg 3793561 atcggaatgt caccgagatc ttcaaccgta taccccatgt ctgacagcct ctcgatcaga 3793621 tgagcgtacc ggatggcact cgggcccata tccactccgc gtcgtgcttg tcctaaatcc 3793681 attggcattc caataaccga aatcgtttta tccatctgtg attccacctc aacatttaag 3793741 ataatgtcct atgcgggtta taacaaagat gacttgcgga caacgttttt aaagctctag 3793801 ctgacgattt gcctgctggc gttttttaat gacgacatga taaatgatgt agcaaatgat 3793861 cataaacggt acgccgcaat acagcgcgat acgctgctcc ggatcaaatg caagactgat 3793921 gagcacgacc gtatttaacg ttaggccgat cagcggaagc accgggtaca gcggtgtttt 3793981 aaatttcaaa tcttctatct tcccgccctc acggatatat ttgcgtctga acatgatttg 3794041 ggaaagcgag atcgtaatcc agccgacctg cgcgctcatg cccgccaaag ataacagtac 3794101 catatatacg gtttcagcct gcgcaaactt tgtcagaagt gataggcagg ccacagccat 3794161 cgttacgatt aacgagtaca tcggtacacc gcgctgattt gttttgccaa gcgctttgaa 3794221 ggcttgtcct tcattcgcca tcgcgtacag aatacgtgtt gatgcgtata aacctgagtt 3794281 cgcaacagat aacagtgcga ttaaaataac aaagttcatg atatcagctg catatgggat 3794341 tccgatttgc tcaaatacgg caacaaatgg actttccacg acacccgcct gtttccacgg 3794401 aatcatgccg gcaatgacaa tgattgaaag cacaaagaac acaagcgttc tccatactgt 3794461 ctgtttgatg gaccgcggaa tcgttttttc agggtcttca ctttctccgg ctgcaacccc 3794521 gatcagctca gtcccctgaa acgcaaagtt cacagtaatc atcgtaatca gcattgcctt 3794581 tatgccgttc ggaaataacc cgtcttcata aaaatgtgtc aaaaacggcg cctgctctcc 3794641 gcccttcaga tcaatcaggc caaacatggc agctccgccg agaataataa ataaaaggat 3794701 aatcaaaatt ttaatgcctg agaaccagaa ttcagattcc gcaaaggctt ttgtggtgat 3794761 cgcatttaaa ataaacatca gtgccgcaaa gaccagacac cagatccaca cgtctatatg 3794821 cggaaaccag cgttgcatca gctgccccgc tgataaaaat tcaatggcgc atgtaaccgc 3794881 ccagccgagc cagtacagcc agccgaacgc aaacccgaag gccgggctga taaatttcgt 3794941 ggcataggtc tggaaggacc ccgacacagg aaaggcgact gccagctctc ctaagcagag 3795001 catggtcaaa aacatgataa agccgcccac taaataggac agaaccgcgc cgagcggtcc 3795061 cgcttggtta atggtaaacc cggttccaag gaagaaaccg gttccgatca ctccgcccaa 3795121 tgaaatcatg aacaaatggc gtgatttcat tgtccgctgg agctgatttc cgttatcttg 3795181 gtttgtattc acattctgca ccccttcagc aacttgtatt ggatctaagc tggaacatct 3795241 gcatggtgct atcccagttt gctgtccaaa gagtctctat ctatttaata taaaattcac 3795301 ttcttctcat aaagatacat tatactaaaa tactgtagct gagcaaatag ggagtgctga 3795361 tttttctgtt gtaaatttat acaaacgaag tgaatatccc gccatggtgc ggatttatgc 3795421 gtttcgcagc acgtgcttaa ttttctctat cgcccaatcc aagtcctctt tggaaatgat 3795481 taatggcggt gcaaaacgaa tgactgtatc atgcgtttcc ttgcataaaa gtccctcttc 3795541 cttcaaacgc tcacaatacg gacgtgccgc ttcagtcaat tccacaccga taaacagccc 3795601 tctgccgcgg acttctttaa tgacagggct gtcaatactc tcaagctcgc ttttaaagta 3795661 ttcaccaagt tcaagagaac gatccgccag cttttcatcc tccagcactt ctaatgaagc 3795721 gatagacact gcacatgcaa gcgggtttcc accaaatgtt gagccgtgtg agccagggtt 3795781 aaacacgcct aggatctcgc ggtccgccgc aatgcaagag atcgggaaca caccgccgcc 3795841 aagcgctttg cccaagatat acatatccgg aacaatgccg tcccagtcac aggcaaacgt 3795901 cttgcctgta cgtccgagac ccgtctgaat ttcatccgca ataaacaaga cattctcttc 3795961 cttacaaatc gccgccgctt cctgtaaaaa tccttcaggc ggaatcacaa tgcccgcttc 3796021 gccttgaatc ggttcaaaca agaatgccgc tgtattcggc gtaatggcct gtcgaagcgc 3796081 ttccacatcg ccgtaaggaa tgagtttgat tcctggaagc atcgggccga atcctcgttt 3796141 atattcctct tcagaagaaa gagataccgc cagcatcgtg cggccgtgga agttcccgac 3796201 acatgcgata atttccgctt gattgtcagc tacgcccttc acttcatacg cccagcgtct 3796261 cgccgctttc accgcggatt caaccgcttc ggctcctgta ttcatcggca gaatcatctc 3796321 tttgcctgtc agtttagctg ttttttcgta aaacggccca agctgatcgt tatgaaacgc 3796381 gcgtgacgtg agggtgattt tatcagcctg atcctttaat gcctgaatga ttttcgggtg 3796441 tctgtgcccc tggtttaccg cagagtaagc actcagcata tccatatatt cattgccttc 3796501 cgggtccttt acccaagcac ccagcgcttc agaaataaca atcgggagcg ggtgataatt 3796561 gttggctccg taatgagacg tctgatcaat aatttctttg gatttagata aagctgtcat 3796621 atttgaattc ccccttgttt tctgtttcaa catgttatcc tgctttccct ttatataaat 3796681 gcaagttctg tgccaaatca agaattcgtg tgttttctac aattttcgag gacaaggtgc 3796741 aaaaacattc tgatatttcg agcgaaaatt tcagcaagtg caaaattctt ttgcatatcc 3796801 tctccgtttt tttataaaat agaagcaata ttaagaaaat aattgaggga ggttcataca 3796861 gtggtcaaag acagcgaatt cctcacattg gtttttcaga gtattttaga tgaaatcgat 3796921 gttggcctgc acgtggtaga cgagcatgga aacacaatcg tttataacaa taaaatgatg 3796981 cagattgaag atatggagaa gcatgacgtc ttgaataaaa acctgatgga tgtgtttatg 3797041 ttttcaaagc agcaggacag cacactggta caggctcttc aggaaggcaa gacgattaaa 3797101 aacgtcaaac agagctattt caataataaa ggccaggaaa ttacgacgat caatcataca 3797161 tatcccatcg tccaagacgg caaaatcagg ggcgccgttg aaattgccaa ggatgtgaca 3797221 aagctggaac ggctgatcag ggagaatatg aacaaaaaag gcagcacaac ctatacgttt 3797281 gacagtattc tcggcaccag tccggccatt caagacgtca tcgaaaacgc caagcgggca 3797341 acccgtacgt catcatctgt ccttctagca ggcgaaaccg gcacgggaaa agaactgttc 3797401 gcgcaaagta tccataatgg aagcgatcgt tctggcggcc cgtttatttc gcaaaactgc 3797461 gcggcactgc cagacagcct tgtggaaagc attttgtttg ggacgaaaaa aggcgcgttt 3797521 accggcgctg tcgaccagcc cggcctgttt gaacaagccc acggcggcac actgctgtta 3797581 gatgaaatca actcgctgaa tctcagcctt caggcgaagc tgctgcgcgc ccttcaagaa 3797641 cggaaaatca ggcgcatcgg ttcaacaaag gatacaccga ttgacgtacg tattattgcc 3797701 acgatgaatg aagacccaat tgatgcaatt gcaggcgaac gaatgcggaa ggacttgtat 3797761 tacaggctga gtgtcgtcac actgatcatc ccgccgcttc gggaacgaaa agaagacatt 3797821 ttgcttctcg cgtcggagtt catccagaaa aacaaccatc tgttccaaat gaatgttgaa 3797881 cacatcagcg atgacgtgaa gcaatttttc ctttcttatg actggccggg aaatattcgc 3797941 gagcttgagc atatgatcga aggcgcaatg aatttcatga cggacgagca aacgattacg 3798001 gcttcccatc tgccctatca ataccgcatg aaaatcaagc cggctgacat cccagagccg 3798061 gaaacaccaa gacaccagcc agccgcggac ttaaaagaaa aaatggaaag cttcgaaaaa 3798121 tatgtgatag agaacgtgtt aagaaaacac ggccataaca tctcgaaagc tgctcaggag 3798181 cttggcatca gcagacaaag cctccaatat cggctgaaga aattttctca ctcgtctaac 3798241 gaataatccg gagcaggaag cctgatcaga aaaacagtgc ctctgccgat ttcacttttc 3798301 acttcaatcg tcccattgtg attgtcgata atcgatttcg ttatggcaag gcctaatccc 3798361 gaacctccat atttccggga gcgggatggg tctgccttgt aaaaccggtc aaacactaaa 3798421 aaacgtcact tcttatgcat tgaagaaaga aaatggcacc tatgtgtatc acagccagca 3798481 accacacggt acaaaccatt aaagtccatg caaataacgg aagtatttgc agctaactgc 3798541 catttgctgt ttcacgtgta acatccatct tgtatttttc ttcatattcg atatatcctt 3798601 tttcaactga acgggcgtga cccctgttca gttttttttg catatcaaaa cagcctggca 3798661 acgatgccag actgctttta ttaactgcct aattggtctg cggaggacag cttgatatca 3798721 acagattttt cttttccgcc gcgataaaac ttcaccttca cccggtcacc gacttttttc 3798781 tgataaagcc gttttcgcag gtcaacaata tcatttactt tgtatccgtc aaattccgtg 3798841 atgacatcca gttccttcag ccccgctttt ccggcaggtg aaaaggcgtc tacacccatc 3798901 acaaccgctc cattggtgac gttcttagga agctttaatg tttcatccca atgatagctt 3798961 gcgatgtcac ttagcgattt catctcaatg ccaaggaacg ggcgtttgac ctttccgtat 3799021 ctctctaaat cctctatcac agggatcacg agcttagacg gaatggacag gccaatccct 3799081 tcaaccgctg actcggcaat tttcattgaa ttgatgccaa tgaccttccc atccatattt 3799141 aacaaagcgc cgccgctgtt cccagggtta atggccgcat ctgtttgcag gacttcagcg 3799201 ttccagtcag gctgtccatc accgtttgaa tctactggga tcgccctctc cgtacccgag 3799261 atgacgcctt gtgtgacaga gcctgcaaac tcaaggccta acgggttccc gatcgcaata 3799321 accggctccc cagacttcac tttatctgaa tttccgaaat cagcgactgc tttaatctta 3799381 tcgcttttca cccgtaaaac ggcaaggtcc atcagctggt cgctgccgac aagatcagct 3799441 gatacacgtg agccgtcttt caagctgatt tcaatttggg aagcgccttc gatgacatga 3799501 tggttggtca cgacataagc ggaatggtca tttttcttat agatgacgcc agagccgctc 3799561 ccagcctcgc cgctctctcc ccaaatatct gatttttgga tgttcacaac accgacaacg 3799621 gcgggcgaca tattgctgac aatcttggtg acggcattgt tgacactgac attcaccgtc 3799681 ctgattgatt cccggccatt gttgttttgc tgctgatcta aggcgcctgt atccagccct 3799741 tcatttgaaa ggtacggcat gataaacgcc attaatacgg caccgacaat cacgccaatc 3799801 agactcgaaa gaaaatatcc ttttttgctt ctctttggct gttcaggagt agtatgttct 3799861 tcctcacgtt cgtaatccac catattccat cctttccaag aacgttaata tggttatatt 3799921 gtgggttaga aactcctaga atagtcatga tttacataga aaaattatac agcgcaaagc 3799981 ggagtggcct tcttcggatc ggtgtcgtat aagtcaaatg tctcacccgt cacaaatcct 3800041 ttagaagcca atgtctgctg cacagacatt cttgccagct ccttcatgtt gttgtcctgg 3800101 ctcaaatgcg ccaggtaaat acgagacgtc tcatcgccaa tgacatccgt catcgccaag 3800161 gcagcatctt catttgacac gtgcccgacg tcacttaaaa tccgccgctt aatgctccat 3800221 gggtatcttc ccatttgcag cataccgaca tcgtgattgc tttcaaacac aaatacattc 3800281 gctgaacgga taatgccttt catccggtcg ctgacatatc ccgtatctgt cattaacgcg 3800341 agctttcggc cgctataatg gaatacataa aacatcggtt ccgccgcatc gtgggaaacg 3800401 ccaaacgatt caacatcaag tccgccgaac gacttcaccg tctccattgg aaatacaaac 3800461 ttttgatcgg tgtcaatttt gccgatttga ttctccatcg ctttccaagt cttctcattc 3800521 gcatagatcg gaagcttgta ctttctggcg acgacaccaa ggcccttaat atggtcacta 3800581 tgctcatgcg tcacaaaaat gccgtctaca tcatccagct tacgcccgat ctgcgccatc 3800641 agcccatcca tggcttttcc gctcaaaccg gcgtccacta aaaatgcgtg atcctctgtt 3800701 tcgaggtaaa acgcatttcc cgtactcccg ctcgcaagta cgctaaattg caagctcatg 3800761 tttgtctcac tccattattt tcattgatct gtatctaaaa tcgtactctc caaagcattc 3800821 acagtaaaat actcttgtac tgtctttttc tcaccgttca cttttttctc gtactcgacc 3800881 gtaattctcc ataccggcgc cagcacctgc gtacttgtca gcggatattg tgctacatag 3800941 ccgaatttac agctcttcac agtgctgtat tcttttaatt gattttgata gtacaatagc 3801001 tcaaccgcat ccatttcagt aattaagctt tctttctgga tttgcttgaa ggtctcaagc 3801061 gtagtctggt cgtatgacac aacctcgttt ttaccgttta agtgcagcac cacttgcccg 3801121 atcatattag agggattgtc ggtcttttgg taaatataat gaccttcgta cgtttggaag 3801181 aaaataattt ctttcttcga tttatcaacc ttccaaagct tatatttttc gccatcttga 3801241 attttcgaag aaacaagtgc ctgagcatcg tcctcgatat ccttctttga tagtgcgatt 3801301 ggatttgcaa acttcatttt caggctcgtt actttatgat catcactagg catgtccatc 3801361 aaaggctttt gatccttcag cgcctcaatt tcctccttgg agaaagactt ttgatttgcc 3801421 gtgatccgat agccttctgt tgcttcctta ttcaagcctt catacgtgat atgatcggcc 3801481 ttcatgtcat gctcgacatc atttttaatg acttcatatt ctttgccggt agcctgccat 3801541 ttttgaaaaa actgatagcc taagaaaata tctaaaatga ggaaggcaac gatgaagatt 3801601 gattttgtct tattccactc cactgttagc cccctccttc ctcaataaat cctttgtaat 3801661 cggcacaatt tttccattta ctttcatcgc ccaaaccggt tccagttcaa cgagaggatc 3801721 atcgttggtt gatgttgata ccaattgata agcaaggaag atctgatcaa ttttgtccgt 3801781 atcataagcg gtttgtttcg aaagcagcat cttcacttcg ctgccgccca tgagctctgt 3801841 ttcacttgtt ttaatcggat tcgttccgag actgtaattc ggccgcttat agctgagaat 3801901 atcatcattc gcccattgca ccgtaatcgc cgatgtcgcc ccgaaaggtt tggcggtgct 3801961 gttaatgacc gggatctgat ccataaaaat atagaagctc aactgctggc tgtcattgat 3802021 attgaaaaat tgatagtgat ccgtccagct tccggtatcc tcaaggtatt tttggctctt 3802081 tttgattaat tcacctgttt gataggatgt gctctgcacc aaattgcgct gctgaaattg 3802141 cacctgtctc tggcttagat tcacatctaa ccggctgatc ccatctgtca gcacatttct 3802201 gttggtgtaa ttcgaatctt ctcttacaat gctcggatca ctaaacaaag cctgcttaaa 3802261 ggtatttgtt ttaatcgatt ctgtgacaaa ttcttttttg tccatcgtaa gcggtttgtt 3802321 cggcagcaag aactctttct ttgagccaat ggagaacaaa ctgaacgccg gcatatttga 3802381 ttgcctgttt ttcaagtcgt tcataatgtt ccggtagttt gctgattcaa ccgtcacttc 3802441 aagaatgagc tgcttgctgt atgacaccaa atagattttc ttgttcgctt ttgtttcatt 3802501 gaacgggatc agaatatggt caaacgaact gtattcaaac gactgattag accatttaaa 3802561 cagcgtttgg aaaatatcaa tcgggatcgt atcgctgaat tgcaagtcaa gcttggcttc 3802621 agaaccgcct attccataaa accagctttt gaatccagcc ttgtcatact gatccgaaat 3802681 atctttaatt cctttcacat cccaatgcgg caagtcagac caaatttctt catagagggc 3802741 attgtcatcc actttgtaat gagcgccgtc atcatggata aacatgtccc ttggccttac 3802801 cgtttcagac agcttttggg tggttttttc gattttatgt ttcacacgaa cagtagactc 3802861 tgttgaggat gagccttcag aaaagtttgg ctggaacgtc catatccccc atgtaaaaac 3802921 aagactgatg acgacgagta ccgtaagtaa tatcgttttt atattttcac gcttcatccc 3802981 aatcatcctc ttgttcctct ttatatggaa gagtaaatgt aatcgtcgtg ccttttcctt 3803041 ctatgctgtc cgcccaaata tctccaccgt gcgcctgtac catttccttg gcaatcgcca 3803101 atcccagacc ggtgccgcca agctttctcg ttctcgcttt atccaccctg tagaagcggt 3803161 caaagacttt ttcgacatct tttttcggaa tgccgatccc ttcatccttc acgctgatat 3803221 agagaagttc ttcctcttca ttgacatcaa tcgagaacgt gacatgtccg ccttccggtg 3803281 aatattttaa agcgttagaa ataatattat cgagcacctg cgttatttta tcctggtcaa 3803341 tctcgacata cagatctctg tccggcagat tgcggataaa ctccacatgc tgctcttttg 3803401 tcatttcaaa acggtcaata ataagtgaca taaaccggac aatctgaatc cattcccggt 3803461 taaattgata atctttactg tcaaatttcg acagctgaag cagatcattg acaagccgga 3803521 tcatacgctc tgtttcattt tgcgtcacca ttaagaagcg cggagcaatg tctttatttt 3803581 cccacgcgcc ttcagctaac gcttctaaat agctgcgcat tgtcgtaagc ggcgtccgca 3803641 gctcatgtga tacattcgca acgaattctc tgcgttcctg atccattttc tcttgttcgg 3803701 ttacatcgta aatgacagcg attaaaccat caattttgcc gtgttccctt tgaatcacag 3803761 agaaattcac gcgaagcacc gttaattcat catcgcgctc aatttcaagc agcatagaat 3803821 cctgctgttc cactaaatct tcaaaagtat aattctcttg aagccccagc aaactcgtaa 3803881 tcggcatttc taaggctgtt tcacgtgaaa cgttcaacag ttccagcgcc gggctgttta 3803941 agagaataat cgctccgttt cggtttgtgg cgataacgcc gtctgtcata taagcaatga 3804001 cagaggctag ctttctgcgt tctccttcag tcatcgcctg ggcatcttca agctctctcg 3804061 ttaagtggtt aaacgttgtg gccagctgcc caatttcatc atgtccatac tttttaacct 3804121 tcctcgagaa attccctttc gcaagctcca tcgcctgctt tcgcatatct gaaagcgggt 3804181 gggtaatggt tcttgccaga aaaataccga gaagagccgt caaaacaagt gccaaacctg 3804241 tgccggacgc cagtatcgtg ttgatcgtct tcatttgatt aaagacatct tccatactcg 3804301 cgacaacgta gatcgcgccc acaacctctt ggttttcagt catgacgggc ttcgcggaaa 3804361 taagaactct gattttgctt ttcgggtcat aatattttct taaatacgac tgtttggtag 3804421 aaaagattct tttgaaaatc agatcggtcg tttgtttccc agccacttcc tcaccgtacg 3804481 gctttgaaga accgaccact tcatagcttt tatctacaaa gctaatttcc cgaacctcat 3804541 cacttttcgt gaagtcattc aaaatacggc tgacgtcatc ctttatgacg gtactgtcgt 3804601 tatcgctctt atattcttgt tcgatataat aagaaaggtt gtcgattcgc tgattcagcg 3804661 attgttcata agagctgatc agcgacttct ctacctgatt gacaaaatac acaccaatga 3804721 tttgcatggc aatgataatc aaaagcacat aaatcaaggt aatcttaaat tggatcgacc 3804781 gaaaaaaacc aaccttattc atatgggcat tagtcctgtt ctgggtttct caagtaataa 3804841 cctacaccac ggcgtgtgac gatccaattt ggatggctcg ggttgtcctc gattttttca 3804901 cgaagccggc ggactgttac gtcaaccgtt ctgacatcgc cgaagtaatc atagccccaa 3804961 acggtttgaa gcaaatgttc acgggtcatc acttgtccga tatgttttgc taaataatga 3805021 agcaattcga actcacgatg agtcaattcg attgtttcgt ctcgttttga tacaacgtac 3805081 gcgtcaggga agatgacgag agagccgata tgaatctcgt tagaggaagg ctcttcctcc 3805141 gcaggcgctg ttgtcagctg gcggcgcagg ttcgctttta cacgcgccaa gagctcgcgt 3805201 gtgctgaatg gttttgtgac atagtcatca gcaccgattt caagcccgat aaccttgtca 3805261 atttctgaat ccttagccgt cagcataatg attggcatat cgtatttctt tctgacttcg 3805321 cggcatactt caacgccgtc tttatttggg agcataatat ctaaaagaat taaatcaggc 3805381 tgaagctctt ctaccatttc aacggcttcg tttccgtcgt gggcacagtg cacttcatag 3805441 ccttcttttc ttaagttaaa ttccaatata tctgcaatcg gtttttcatc atctactaca 3805501 aggatctttt tatccatcat tttgattttc ctcctgccga atgacttcat ttcatctata 3805561 taacattcgt ttcatcactt atggcccatg taaagaatgg gtccttgtct attataacgg 3805621 tttaaggtca aaagataaaa aaaataaagg tttagaaaaa aaacacatgt ttcaccttta 3805681 tcgccagttg tttatctatt gtcatgctgg tcaacttttt ttaaaaaaga taactttatt 3805741 gaaacctccc ctcaccggag tgcgtcttta tcaatgacgt cttcttcttt gaaccggccg 3805801 cagggccggt tctccctttt tcttctatta taacactcct catgtttgcc tttttcctaa 3805861 aagaaaaaac gcacctacga ttgcagatgc gtttggtaag tggctcggga cggaatcgaa 3805921 ccgccgacac acggattttc agtccgttgc tctaccaact gagctaccga gccaaatgtt 3805981 ttatttttct ctactaagta aagtaaaatg gcggtccgga cgggactcga acccgcgacc 3806041 tcctgcgtga caggcaggca ttctaaccaa ctgaactacc ggaccttaca gtaattgccc 3806101 ggagagctgt cgtgtcagct ctcacagaca aataaggaat ttagcaataa cgctaaagta 3806161 aatcaatgac ccgtacggga ttcgaacccg tgttaccgcc gtgaaagggc ggtgtcttaa 3806221 ccgcttgacc aacgggcctt cacgaaatgg tgagccatga aggactcgaa ccttcgaccc 3806281 tctgattaaa agtcagatgc tctaccaact gagctaatgg ctcttaaaga tgtcggaatt 3806341 tctatagagc aaacgactta aatctagttc tcatcttgta ctctattgaa gcagtttccg 3806401 taacaacgag atttataata tcacgaacaa atagaagtgg caataacttt tttggttttt 3806461 tttcatattt ttttctcaga ccaacttata tgcggctttc aaacaaaaaa caagcccctt 3806521 aaataggggc ttgcagacat attctattta gttcgcacgg tacacactgc gaaggacatt 3806581 tgtttgtgag cggtctggac cgacagagaa aatagaaagc ggaatgcctg tcagctgaga 3806641 cacacgctca agataatggc gcgcattttc cggaagctcg ctcaagctct tcgcacctgt 3806701 aatatcctca gtccagcccg gcatttcttc atataccggc tcacattcag caagtgcctt 3806761 aagacttgct gggaattctt caatgatttc gcctttgtag cggtacgcca cacagatttt 3806821 caacgtttca attcctgcta ggacgtcaat tgagttcaga gaaagatctg taattccgct 3806881 cacacggcgg gcgtggcgga caacaacgct gtcaaaccag ccgacacggc gcgggcggcc 3806941 tgttgttgtt ccatattcgc gtccgacttc acggatttga tcgccgattt catctttcag 3807001 ctcagtcgga aaaggaccgt cgccgacacg agtcgtatat gcttttgata caccgacaac 3807061 gtgcttgatt ttggtcgggc cgacaccaga accgatcgtg acaccgccgg caaccgggtt 3807121 agatgacgta acaaacgggt atgttccttg gtcgatatcg agcataaccc cttgtgcgcc 3807181 ttcaaataat acacggcgcc cttcatcaag agcatcgttt aagacaacag atgtatcgca 3807241 aacatacttt ttaatctgct gtccgtactc ataatattcg tctaagatat cctcaagttt 3807301 aaacccttct gtctcgtaca ttttctcgag aagacggttt ttttcttcaa gattgcgctc 3807361 aagcttttcc gcaaacgcgt cacggtctaa cagatccgcg atgcgaattc cgatgcgggc 3807421 tgctttatcc atgtaagcag ggccgattcc ttttttcgtt gtgccgatct tgttagcccc 3807481 tttacgctct tcttccactt catccaattt caaatgatac ggcagaatga cgtgagctct 3807541 gttgctgatt ctcaggttat ctgtactcac gttgcgctca tgaagatacg caagctctgt 3807601 gactaatgct ttcggatcta caaccattcc gtttccgatt acacacgttt tatccttata 3807661 gaaaattcca gacgggatta agtgaagctt atatgtgatt ccgtcaaact tgattgtatg 3807721 ccctgcgtta tttccgcctt gataacgggc gatcacttct gcattttctg ataggaaatc 3807781 tgtaatttta ccttttcctt catcgcccca ttgcgtacct actacaacta ctgaagacat 3807841 gtccgtgcac ctccgttaac ctttcaaaac gattctattc aaacaaatca agtttatcag 3807901 tgaagaaaca gaaagtcaat tgtaaatccg aacattaatt tattgtaaat ctatattcgt 3807961 tcgcttccat tcgttttata agcgttttct cactgctttg tcataaaaag cttgcgaaac 3808021 tttcatcctt tagcataaga aagaatcact tgcctgatat cccttttgaa ttcataaaaa 3808081 cgatccgcca gccgtccggg tcctctatcg tcacgccccc attgctccag tacgggttct 3808141 ctgattcgac ctcttgatag cccatgtgct ttagctttga agtgatcgct gccagttcaa 3808201 ctgcattcgg cacataaaaa acaagaaggc tgtcgggatg gggaacgggg gcagtgcttc 3808261 ccccttcata ctgggtgaat tccaaatgat aatcggcatg aggaaggccg aacatgacac 3808321 cgtcataccc gttatgctgt gaaaattctc ctattcgttt caaacacagt ccctcttcgt 3808381 aaaaacgaat aatctcatca agctggcccg taggacgcgc aattcggatt tgtgctgctt 3808441 gaaaagacga aaaacgtttt cccatattgt taccatctcc tttttgcacc attttattaa 3808501 aacgctttca atttttcatc cgctgagcga acgtcatttc ttccatcttt cgaatgaaaa 3808561 aaaccccaag agcagctctt ggggcttatg cgccgggcgg aacgcctgcg tcatcaaaac 3808621 gccgttccag gttgacgaat ttgttgtatt cttttacgaa cgcaagagac acggttccta 3808681 ccgggccgtt acgctgtttg gcgataataa tttcgataat atttttattc tcggtttctt 3808741 tgtcatagta gtcatcacga taaaggaacg cgacaatatc cgcgtcctgc tcgatacttc 3808801 ctgattcccg gatatcagac atcatcggac gtttatcctg acgctgctca acacccctgg 3808861 aaagctgaga aagcgcgata acagggactt gcagctccct cgcaatcgac ttcagttcac 3808921 gggaaatttc agatacttcc tgctgacggt tgtcctttga acgaccgctt ccctgaatca 3808981 attgcaggta atcgatcaaa atcatgccca gcccgctttc ctgcttcaag cggcggcact 3809041 tggcacggat ttcactcact cgaatacccg gtgtatcatc gatgtaaatc ccgctgttcg 3809101 ataggcttcc cattgccatc gtcagcttgc cccaatcctc ttcggtcagg ttacctgtac 3809161 ggagattctg ggcattgata tttccctcgg cacagagcat acgcataacg agctgctcgg 3809221 cacccatctc aagactgaaa atcgctacgc tctcatcggt cttcgtcgcc acgttttgtg 3809281 cgatgttcag ggcaaaggct gttttcccta ctgaaggacg ggcagccaca atgatcaagt 3809341 cgttgcgctg gaaacccgca gtcatccggt caagctccgt aaaccctgtt ggaattcccg 3809401 tgatatcacc ttttcgattg tgaagctgtt cgatattatc ataggtctgg acaaggacgt 3809461 ccttaatatt ttggaaggca ctcgtgtttt tgcgctgtgc cacttccata atcgtttttt 3809521 ccgcttcact gagtaaatcc tcgacctcat cctcacgggt atacccgtct tgagcaatcg 3809581 ttgtcgcagt tctgattaat cggcgaagaa tcgatttttc ctcaacgatt ttcgcgtaat 3809641 attctatgtt agccgctgtc ggcaccgagt ttgcgatatc tgtcaaatat gaaataccgc 3809701 ctacttcttc cagcaggtct gtgttcgcaa gctctgatgt aactgtcacc agatcaaccg 3809761 gttcacctcg gtcaccgagc accagcatcg cattatagat tttttggtgg gacattctat 3809821 agaaatcatc tggaatcaat acttctgaag ccagtgttaa agcagacggc tgtaaaaaaa 3809881 tagcgcctaa cacggcttgt tcggcttcta tattttgcgg aggaagccgg tcattcagaa 3809941 ggtctgtcat gctaagcacc gtcctctcat taaaaaatct ccaacctcca ttctaccatt 3810001 tctacagaaa aaaaatagaa aaattgtctg tttcctgttt ttttcagtta gcagattgga 3810061 tcgtttcgga cagtaacaag gcgggaaaaa tgcaataaaa cataagggag gaatgaaaga 3810121 tgataaagaa atatgcgatt acacctaatg ttgatgcgga cggctggttt attgaggtgg 3810181 agaatgtagc gccgacagct ttgtatacgt ctaaagacgc cgctattgaa aaggccaaac 3810241 aggtggctaa ggaaaacagt ccgtctaagc ttgtaattta tgaccagttt aaaaatgtgg 3810301 aagaagaaca ctcattttaa tgaatgaaag ccttcgctgc agcgagggtt ttttagcggt 3810361 tatcggttta tttcatccat tggatgccta tgtgcatcat caaatctgcc gctttttgat 3810421 acagatccca ctccccgatc gaagcaaatt tccccatcag ctcctgaagc tttaacctca 3810481 ttgctatata ttcttcgaaa gtgacagctt tttcagtgtc tatttggtgt tccttcagca 3810541 tttgttttaa taaggataac ggtgcgtgca taagaaccct ccttacctct tttataacgg 3810601 tcattttccg attgctctat tcctttgtga catcttctta catttcacat ctgattcttg 3810661 tacaatggac agaagagagg agggatcttt tgtgagacct ttgcaaattt ctgccgaaac 3810721 tgcacaaaag cttgcagagt ccttgaatct gccgcttgaa cagatcatgc atatgcctca 3810781 gcatattctg cttgccaaaa tggctgaact gcaaaaagag gacaaatcat agccttcatt 3810841 cacatacttg cttacctgtt tcgggataat atcatgtata tgttagaaaa gaggagtaac 3810901 tgctttgcca catccacata ataaaaaaat ccaatcattt tggctgatca ccggcattat 3810961 ctttatcgcc tttaacttac ggcccgcgat cacttcagtc ggtccggtca tcagctctat 3811021 ccgggcagag ctgcacatgt ccaatggggc agccggtttt ttgaccgcac tgccgctgct 3811081 ttcgtttgca gttctttctc cgcttgcacc taagcttgga cagcgcctcg gtaatgagcg 3811141 aactttatgg ctaggtctcg tgatactgct gatcggtgtt ctgactcgtt ctaccggcta 3811201 tactgccgct ttgtttttcg gaacagcact tatcggcgtc gggattgcga ttggtaacgt 3811261 acttttgcca agcttaatca aacataaata ccctgaaaag ccagggatca tgatcagcct 3811321 gtatacgaca tcaatgaata tattcgcagc tttagcatcg ggtgtcagcg ttcctttagc 3811381 gacccagatg aatggcggat ggaaacaagc ctttctctta tggggcgggc tggctttact 3811441 tgcattgcta atctggatac ctcagctgcg ccatcgagat acggcaaacc agacaatgaa 3811501 gctgcaatcc agttccattt gggcttccaa aatggcatgg tatgtcacca tctttatggg 3811561 cctgcaatcg tttttatttt acagcagcat cgcttggttt cctgaaattc tccgttcaca 3811621 cgggattgat acggcaacag ccggatggat ggtatcactc atgcaatttg cgagtctgcc 3811681 ttccactttt ctgacgccag ttttagctga ccgtgtgaaa cagcagcgcg gtatcgttgc 3811741 ggcgctggcc tcagtttatc tgatcggcct ttgcggatta ttagcgggcg gaagccatac 3811801 attgcttgcc atctggatga tcattatcgg tatcggacaa ggctccagca ttagtctggc 3811861 ccttactttg attggtctcc gcagtgaaaa tgcccaacag gccgctgcgc tgtcaggcat 3811921 gtctcagtca ttcggctacc tgctggcagc agtcgggcca atctttgtcg gctatctctt 3811981 tgaccagacg cattcttgga cgatgccgat tgtgcttctc attgctgccc tgatcgtaat 3812041 gggagcagcc ggacagggag ccggacgaga tcgatacatt ttccagtcag aaaaacaaag 3812101 aaattcagca taaagcgggg aagatatctc cgcttttttc tttgaatatt tatggtttat 3812161 tcataagttt ttcatatttg ttttttacaa tgagacacca taaagaggtg aaaaacgatg 3812221 aaaaccaaac gattcgacgc agcccttatt cttattttgc tagcagcagc ttttttgaat 3812281 acgtatcaca tttggcagga tgatacagca aaccagtact atttggcggc tgtaaaaagc 3812341 atgacgcaaa gcttccataa ctttttttat gcgtcatttg acccttctgg atttgtgaca 3812401 gtagataagc ctcctgtcgt gttatggatt caaacgattt tcgcactgat tttcggtgtt 3812461 cacacgtgga gtgtcatcat tccccaggct cttgccggag ttggatctgt cttccttctc 3812521 tacagaatgg ttaagccgac ttttggagtt ggagcggccc gcattgccgc acttgtcatg 3812581 gcactgaccc ctatcgcagt agctgtcagc cggacaaaca atatcgacag catgcttgtt 3812641 tttaccttat tgctcggttc aacttgtctg cttagggcag taaaacaagg caagctggtt 3812701 tggctgctga cggcatttgc cctgattggg ctcgccttta atatgaagat gatgcaagcg 3812761 tttatggtat tgcctgcatt tgtgttattc tacctgattg catctcgggt ttctctgaag 3812821 aaaaaaatcg ggtccctgct tctgtctctt gtccttctga caggcctttc actctcatgg 3812881 gcgattgcag tggattcagc ctcttcctca agccggcctt atgtaggaag cagccagact 3812941 aactcagtgc tagaactggc ctttggctac aacggcacag agcgtctgtt tgggcaaact 3813001 acgggccttg caaagggtga tatgaatgct gctggcggag ggaacatgca gaatcaagac 3813061 aacatgcaag cgccaaatgg caacggttca tctttttctc agaacggtaa tcaatcattc 3813121 ggaaaccatt cacaggcgcc tcagccgcct aacggacaaa ccggcgctct caatggaggc 3813181 ggaggcacac ctcccacagg tggcaacgga cctggaaatg gagggcctgg cggcggaggc 3813241 ggaaaaagcg tgaatatgtt cggcaccggt gatcctggac cgcttcgtct cttccaatca 3813301 gcactttccg gccaaatcag ctggatgctt ccattctcat tgatcggatt actgggcgca 3813361 atcatcagct ggtaccgtga tcgccgcgga catgctgcta aaatgaaaga aacgctattc 3813421 tgggcggctt ggcttgttcc cgtggctggt ttcttcagca tcgcaggatt cttccaccag 3813481 tattatttga ttatgctggc accgccgatt gccgcccttt ctggtatcgg atggtatacg 3813541 atgcaccgct tatacaaaaa taataaagac tggtccagct atcttctgcc ggcagccgtc 3813601 ttgatcacag ccgtgtttca ggtgtatatt ctgagcgctt atacaagcca aatcggcagt 3813661 gtatggatgt atgtcctggg gctcttagga ctgggcatca cccttgcact tctgatgctt 3813721 aaacgcagcc atccgttcag taagctgctg accatcatca gcttgtgcgt tctgcttctc 3813781 acaccagttt actggtcagc aacgccgctt ctatacggtg gcaacagcgt ccttcctgaa 3813841 tccggcccgc agctcaaagg ctcagcaaac ggcgggaaca tgttctcttc agaggtcgac 3813901 agcgggctcc tgtcctatct gagaaaacac aataccggcg aagagtattt atttgctact 3813961 ttgacaaccg taacagctgc gccatacatc atttacgaaa atgaatctgt tatggcaatg 3814021 ggcgggttta acggcacgga tcccattctg actgtgtcgg aactgaaaaa actgatcaaa 3814081 gaaggcaaag tgaaatactt ccttctgtca gaaaacaact caggcaacag cgaacttgtt 3814141 tcctggatta agaaaaacgg aaaagaaata acatctgacg agtacagcgg ttcctccagc 3814201 agcacaaaca gcgtgcaggg aatgcgaaga ggacctggcg gagaaagcca gcaaactctt 3814261 tatctcgtgg aataaaaaaa gaggcttgga tgaatccaag cctcttttct attaagcttc 3814321 ttcttttaca tgtaccttta acacagcctg cacttcagga tgcagcttca caggcacgtt 3814381 tgtatatcct aatgcacgaa tgccgtccgg cagttcaagc ttccgcttat ctactttaat 3814441 gttatggtct ttttggagct gttcagtgat ttgcttgctt gtcactgaac caaataaacg 3814501 gccgccctca cctgattttg cgctaagctc aacagtcagt ttttctaatg tctctttcaa 3814561 gctcttagcc tgctcaagct cagcaatggc ttcttttttc tctttctgct tttgtccgtt 3814621 taacgcgctg atgtttgacg cgttcgcttc aaccgcgagg ccttttttaa ttagaaagtt 3814681 atgcgcataa ccgtctgcta cgtttttgac ttcgcctttt tttccttttc cttttacatc 3814741 ttgtaagaaa ataaccttca tctctgtacg cctccctcaa aatactcatc tatggcgtgc 3814801 ttcagccgtt ccagcgcttc agaaactgaa atgccggaca actgagtcgc cgcatttgtt 3814861 aaatgccctc cgccttccag ggcctccatg atgatctgaa catttacctc gccaagcgac 3814921 cgagcactga tacaaaccgt ttgttcatcc cgtctcgcca ccgcaaatga agcctcaacc 3814981 tcactcatcg atagcagcga atcggcagcc tgcgcaatca gcacttgatc gaagtattcc 3815041 tcttcatttt caggaagaga agcaatcgca atgttatctt tatagaggac cgtatgctgg 3815101 atcagcttcg cccgtttaat ataggaatca acggtttctt tcagaaactt ctgcaccagc 3815161 accgtgtcgg cgccttttgc ccttaaataa gaagccgcat cgaaagtccg cgagcccgtg 3815221 cggagagaaa agctctttgt atccactatt ataccagcta atagggctgt tgcttcaatc 3815281 atattgattt ttaagcgctt cggctgatat tcaagcagct ctgtcaccaa ttccgctgtg 3815341 gaagaagcgt atggttccat ataaacgagc agcggatctc tgataaactc ctcacctctt 3815401 cggtgatggt cgatgaccac gatatgttca attttattga ccagccgttc ctccatgacg 3815461 agtgacggct tatgtgtatc aacgatcaca agcagtgtgt catcattgga aatctccatt 3815521 gcttcttcag gcgtaataaa tcttgaccac agttcttcat attttttgat ttccccaatc 3815581 aaacgctgca cacttgatcc gatttggttt gggtcaatca cgataaaacc atctttgtta 3815641 tttgcctgag ccacctttaa aatcccgatc gctgcgccga tagaatccat gtcggggaat 3815701 ttatgcccca tgataatcac attgctgctt tcggtgacga tttcctttaa ggcgtgagaa 3815761 atcacgcggg cccgcaccct tgttcgtttc tccattgggt ttgttttacc gccgtaaaac 3815821 ttcaccttgc cgtttggcag cttaatggct acctggtctc cgccgcgtcc cagtgctaag 3815881 tccaagctgg attgcgccaa atcgccaagt tctttcaggg aagagactga agccccgaca 3815941 ccgacgctta acgtcagcgc tacaccgtca aacgaggttt tttcccgcac ttcatcaaga 3816001 atcgaaaact tcgaattttc gagttcagtt aagatatgtt cattaagtac agcaataaag 3816061 cgttctgaag acgtcctttt caagaagatc ccgtactcct gcgcccaagc gttcagcaaa 3816121 gatgtcacct ggctgttcat cgtgcttctc gtctggtcat ccaatccttg tgtcacatca 3816181 tcatagttat caaggaaaat atatgccagg acggttcttt cgttttcata tagcttttca 3816241 atctggattt gttctgttac atcaaagaaa tataagagac gctcatcccg tttgatgaca 3816301 accctaaact tgcggtcatt caatgtaacc gtttccgatt ccacctcttg tttgataagc 3816361 ggcactaccg attcacaagt atcgtaaagt gatctcccca ctaaagtgct ttcattaaaa 3816421 caagaggaaa gaaacggatt tgcccattct atataatatt ggtcattaaa aagcatgatt 3816481 ccaatcggca tttccatcaa tgcctcttca ccgacttttt tcaacctgta ggacaacgta 3816541 gaaatataag catcaatctc ttgtcgaata agagaatcag cacgcttaat aaaaaacaaa 3816601 ataactgcca gcagcagcac ttcgacggtt cctaatatcc agttaaaata aaagctgatg 3816661 aggattgtaa taattgacag agcaatcaat gcatagatgg gataccgaaa cagcggtttt 3816721 tcataaaagc ttggcatttc tatcactccc caccatgtga gtaaaactca tgttcacttc 3816781 accttattcc ttatatgaaa gcccatatct aaaacgccta aaatgcgaat ggccgccatg 3816841 aagaccggat gcacaaaccc aagtatgaca gcaatcacag ccgcagcctt tggatattgt 3816901 ttcttatggc aatagaaaaa gataaatgat aaaccttgga tgaaaatcag aaacccgagt 3816961 ataaactccc catttaaagc gatagagtac agcatttggc ctttttctaa aggcaaaaat 3817021 gaaagcatga caataatcaa atacagtact acaacacttt gcggaaactt caactctcta 3817081 aaaggcttta gattaggaat atcgggggag aatcgcctta agagcggctt agcgataagg 3817141 taactgagga aagaaaaaat aactcctacc atcacaatag ctgttggaaa aagatattga 3817201 acgataccca attgttcttc catcagtttt aattgcttct caaactgccc agcattgccc 3817261 gactgcttcg ctacagtttc tacaatatca agagattgcc ggtattgtgt cattgcctca 3817321 tcaatgatat tgatacccaa aaactgaatg cttatcacaa aatagaagac aatactaagc 3817381 atataaataa gagcgcccga aataatggcg tgcccgggct ctttcctttt gaaaaaatgt 3817441 cccatggcaa tgccggcgca agctgacata aaagctacaa taagcccgtt aaaggacccg 3817501 acaataaaaa caaccggaag actgacagcg cccatccata tccctagctt caatccatgt 3817561 ctgatcgtat acaagatcat tggcagcggc agtgcaaata acagaattgt tccaatcaca 3817621 ggaacataaa cgaccagaag cgtaatgatc gcaaacagac tgattaaaat agcaccttcc 3817681 attaaagctc tcgtttgttt cacttagtca cctcgtatca tcctgaacat acgaatagaa 3817741 aagagcagca taaacgactg ctcttttgtt catcgctgca acatgctttg caccgaatgt 3817801 ttttatatca tctctaaatt ttacttttat attttaacat aagtccaaat cgcaagtaaa 3817861 atgacgctaa tgtttcatgt gaaacatgaa aaaggaaaag acattctttg aaaagaatgc 3817921 ccatcacaat taatgtttat catccataaa gccagaagat tccttgtttt tctttttcgt 3817981 ttttctgaca tacataaaaa ttaagatcac cagtaaaagg gttgttgctt gcagaacgcc 3818041 gctgctaaac aagaaaaagt tctttatcat gtcccacatt gtgtttcacc tctttgtgca 3818101 tgttctcaac ccgtatccta tataaggtga atttcccttt ttaaaaactt caaaacatca 3818161 tgaacaacat tgagcgttgg gcatatgctg atatggaatc tgatcgataa aggagaattt 3818221 tcacatggat gaacgcagaa cattggcttg gcatgaaaca ttagaaatgc acgagctggt 3818281 tgcttttcaa tcaaacggac tcattaaact gaagaaaatg ataagagaag taaaagaccc 3818341 tcagctcaga cagctttata acgtgtctat tcagggtgtt gagcaaaatt tgagagagct 3818401 tcttccgttc tttccacagg ctccgcacag agaggatgag gaagaagaac gcgcagataa 3818461 cccattttac agcggtgacc tgctcggttt tgccaaaaca tctgtccgca gctatgccat 3818521 cgcaattaca gaaacagcaa cacctcaatt aagaaacgta ctggtcaaac agctgaatgc 3818581 tgccatccag ctgcacgccc aagtttatcg atacatgtat cagcatggat attatccgtc 3818641 ttacaacctt tctgaactgt tgaaaaacga tgtcagaaac gccaacagag ccatttcaat 3818701 gaaataaaac aagcagcaaa ggagttccct ttgctgctat ttctgctgat ccttcactaa 3818761 gccgttcgaa cgataagatt ccagcacgtc tctgttggat tctccccatt ctttcatttg 3818821 caaaacaatc ggttcaagcg tgcgcccaaa ttccgtcaga gagtactcta ccttgggcgg 3818881 cacctggtga taaacctcac ggtgcacgat gccgtccgct tccagctccc tcagctggag 3818941 agtaagcatt ctttgagtaa tactcgggca gattcgccga aactcattaa atcgtttctt 3819001 gccatctatc atgtgataaa aaagaattcc tttccacttt ccgccaatga catctagagt 3819061 gaattcaact ggacagcctt ctttgttcgg gtatatattc tttttttcac tcattcttga 3819121 ccctccaata gtaccttttt tgatactaca ttacattttg caactaatct acccagtatt 3819181 ttacacacct tttctcctta gctcaaagaa aatgcttctt attcacatca atttttaagg 3819241 gtttgcatga ttacacctgc agcaagacgt gttaaactat ataaagatta cactacttaa 3819301 aaaaggatag gagctatcat ggaaaagata cttattttcg gacaccaaaa cccagataca 3819361 gatacgattt gttctgcgat tgcttatgct gatttgaaaa acaaactcgg cttcaatgct 3819421 gagcctgtcc gcctcggaca agtcaacggc gaaacacaat acgcgcttga ctatttcaaa 3819481 caagaaagcc cgcgtcttgt tgaaacagct gcaaacgaag taaacggcgt tatcctggtt 3819541 gaccataacg aacgccagca aagcatcaaa gacattgaag aggttcaggt tttagaggtt 3819601 atcgaccatc accgcatcgc taactttgaa acagctgagc cgctttacta tcgtgctgag 3819661 cctgtaggct gtacggctac catcttaaac aaaatgtaca aagagaataa cgtgaaaatc 3819721 gagaaagaaa ttgccggcct tatgctgtct gcgatcattt ctgattccct gttatttaaa 3819781 tctccaactt gcacggacca agacgtagca gcagcaaaag agcttgcgga gatcgctgga 3819841 gtagatgctg aagaatacgg cttgaacatg ttgaaagcag gcgctgatct aagcaaaaaa 3819901 acagtggaag agctcatttc tcttgatgcg aaagaattta cactcggcag caagaaagtc 3819961 gaaatcgcac aagtaaacac agtggacatt gaagatgtaa aaaaacgcca agctgaatta 3820021 gaagctgtga tctcaaaagt tgtggctgag aagaatcttg atctgttcct tctcgttatc 3820081 acagatatct tagaaaatga ttcacttgct cttgcaatcg gtaacgaagc agcgaaagtg 3820141 gaaaaagcgt tcaacgttac attagaaaac aacacagccc tcttaaaagg cgttgtttcc 3820201 cgtaaaaaac aagtcgttcc tgtcttaaca gacgcaatgg ctgaataagc aaaaagcatc 3820261 ccgcgtcggg atgctttttc ttattcaccc agcttctcaa tttgtcccat cacatcagta 3820321 atttgctttg cgttttggac caggtctgac tgctccaatt ctttaagcga taccttgcct 3820381 tcctcggctt gtttcaacac atcttcagcg cttttctgca aggtttcgtt atgctcctga 3820441 atggttcgat gaatctccgc tgcggcatca ggcggcgtta attcattaaa atcagcggca 3820501 gccttctgaa tcgactcaag ctgcgcttca agtttttctt tcgcctcggt gtcatttaca 3820561 gctttctcag ccaattcagg cgcttcctct gcaaatgtct tcaccttctc cacataacca 3820621 gctgcttcac tcgtatagtt caatccgtcg ttcacctgat caagcatgcc gcatccgcct 3820681 gcactcaaaa gtcccactcc ggcaagtact gtcaaaatga tcttcatctt cagccccctc 3820741 atcgtttctt tttcattttt tcttttaaga tcggaatcaa tttctctttc gctaacggca 3820801 gccctttcct caccaattca cgcttcagcc actttttcag cttagacatt ctgatgctcc 3820861 tctccctttt tgataaaaat gaaaaaactc caccaatttg gtgaagttcc tgaaacaaaa 3820921 agaccttcac caaatcagat ttggcaaagg tctcgctaac aatgagattg ccagcaaagc 3820981 cgaggacacc ttgtcccgta atgacgactt tactgtgaaa gctactcccc tttggagtgt 3821041 tcatttttat tactttcatt ctaaagcacc gatctgttcc agtcaaattc ctgccgttta 3821101 tataaaagcg cgctgtggta tttaaaattt gaatggtttt tctatcagga gatcatgcta 3821161 tgacagagga ggttttcatc atgagtcaag agcgcgtgaa acggcctggg cataccagat 3821221 ggtacatatc ttcgttactt agcggcatta ttattcttaa ttattttgac cgagtggcca 3821281 tctcggtagc ggcccctgcg atacaagatt cgtttcacct tactgcaact gaactcggca 3821341 tcgtgttttc catttacacc tattcctata cactgatgca gctgcctgtc ggaagtttgc 3821401 tggaccgttt tggggtcgca tgggtcacga gggttggaat gacaatatgg agctttttaa 3821461 cgatccttct tgcttttttg caaggaaaat tgctgttgta tctgttccgg tttctcattg 3821521 ggctgacgag cgcctctgcg ttccctgctg cctctaaagc aaccgctctc tggtttcctc 3821581 caagtgagcg gggattggca aactcactgt tcgattcggc cgccaagttt tcaaatgtaa 3821641 tcggcgcgcc attggtcgcc tttcttgtca caacatttga ctggcgtgtc gcttttttga 3821701 cgattggatg catcaatgtg ctgtttacga tctttttctg gcagtattat gaacagcctg 3821761 aacggcacaa acgcatttct aaaagtgaac taaactatat tcaaaaacac aatgccatta 3821821 caacagagca aatcccttac aaaacgggcc cgcttttaaa aaagcttttc accaatcgaa 3821881 aagtatgggg cttaatgatc ggatttacag ggtacgggta tacattcaac ctgctgctca 3821941 cctggcttcc gactttcttt aaacatacat acggtatgga tctcatgtcg tccggtttat 3822001 ttacggcagt gccgtggctg atctcaacca tttccggaat tgccgtcggc ggctggctcg 3822061 tcgattattt tattaagaaa ggctatccta ataccaaggt gtaccgaacc gtaatcatag 3822121 tcggaatgag ctttggcttt ttctttttag gatccattct gacgaacaat attaccgtag 3822181 ccattatttg catttccatc ggactcgccg gaatttccgc aaccgctccg gtcggctggt 3822241 ccatctccgc agaactcgcg ccgatcggtt ccgtatccat gctgagctcc atggtgaatc 3822301 tcgcaaacaa cctgttcgga ggcattattg ctgcgtcact gacagggtat ttgtttgatg 3822361 tgacaggctc ctttaccctc agctttctgg tagctggttt tgtgctgttg ctgggattgg 3822421 ttttttatgt gtttgtatta ggggatgtaa aacgaattaa actatagaac atgaaaaaga 3822481 gagctgccag ttggcagctc tccctttaca tcaaagaatc ggcccgtccc catttacctt 3822541 ctcctcgtcc tgttcctcta tatcaagccc cgaagctagc atttcctgct ctatctgttc 3822601 gagcacctgc tcgttttttc cttgaagacc accttcataa tgaaaagcat cctgtgtgcc 3822661 gttttcctct attgtcgcta aaatatcgtg gatatcatta tggtctcctg aaatggagcc 3822721 gaatccctgg ttttgttttt tataattcac aaaaccgctg gggaggttgt ttccgaggtt 3822781 tacacatgat gcgctccgag tagtaattca tcagtgtatc aaaatcttca ttttggattg 3822841 ccacatcaca tgcagagatg atgtctttca attgctgttc caaatgaatt cccctaatca 3822901 tcatgattgg atatattata caatgtttga cacgtaggga tccttttcat ttttgttttt 3822961 acggtttcgc tggtccattt ccgcagagct ggcgccgatc ggttccgtat ccatgctgag 3823021 ctccatggta aatctggcaa acaacctgtt cgaaggcatt attgcggctt cattgacggg 3823081 gtattttgtt tgatgtgaca aggctccttt acgctcagct ttctggtagc cagttttgtt 3823141 ctgctgcttg gattggtttt ttacgtgttt gtcttagggg atgtaaaacg aattaagcgg 3823201 gaataaagag tgcttgtaga gaaaacgttg ttctttctac aagcttttta gttttgtgct 3823261 gtttttcaag atattcagct gtcataaaaa gaaaatgagc tcccacatac cggctaggta 3823321 tgtggcgttc ttcttcatgt tctggcatgc agctgtgagg aggatttgtt tgctcacccc 3823381 ctgaacctgc gatagctaag cccgtgcagt tgttttgaac ctacaaagct tcgttctatt 3823441 ttttcttttc tttttttaga gatttcctga aatagaaaag caatcttttc taaccttttc 3823501 tttatggttt tgccatacat accgagtaac gactttctgg cgtttcgttg attttgtgta 3823561 atattctcaa acatatttca ggatttgatt tatatgaccg atagtctttg cgatcaattg 3823621 ttgagtacgt aagtgtatgc tgattcaaca aatgtatctg tattgttcac tttataatga 3823681 aatttccatt ttggaagcaa acccctgact gggtgataac gtctatgtgc gatggcacca 3823741 aaaacttgga ggtcaaatag tcctttagag atgagagttg ttaagtagcc ggaatctaga 3823801 gcgacggctt ctacttgaaa atcaaatcat gcaatttagt gatccaatcg gtcaaggtag 3823861 ggcttggaac agaatcatgg acttttctgg agttgcaaac tattaatcgt cctcattaaa 3823921 tttataataa aaatattctc aattgagcaa atcgcccacc ctttttcctt tataacataa 3823981 aatccaatac tatcaataaa attctttaca ggttattaca gttaagatat aatatagtta 3824041 atcttttacg taaaaggagg tttttattac ttgtgttgaa gttttaaata ggagtaactc 3824101 catctcccca ttacggtctt catttaattt catcctgagt tttatttagt tagatataaa 3824161 aacgaaaatt tcacattatt tttaactaac cgatagtata aaatatatat tgaaaggatt 3824221 gtaaaattat gaataaattc ctgaagagca atttccgttt ccttcttgcg gctgctttag 3824281 gcatatcatt acttgctagt agtaatttta taaaagccag caatgataac tataaattcc 3824341 atttacttgt accttatggc tatggtaatg cctattcaaa tgatgcattt agacagacca 3824401 ctcatacaga taatccttgg aaagtaaatt tacagaaatc ggcagaaggt aaaggtacaa 3824461 tcatgacatt ttggttgatt aacacaggga atagtaaaat tccaaaagct tctaaaatac 3824521 ataacgtaaa acaaggaagc ggagctcatt attatcatgc aaatagccag ggaagccata 3824581 catatgtagc cttagcagtt gaaaacaaca attacagtgc aagttcttat ggtatagatg 3824641 gtgtatggga tgaagaaact tggtaaacaa gaaccttcta aaaacgttgg caccttttag 3824701 ccacgcgaaa aaatttagaa tgataatctt tttataagat tatcattttt atttattcta 3824761 ttaagaattg agtgagaaca tggaaagtca tatttatcgc attatcaaaa ataaattaac 3824821 tataataata tttactataa tcatattaat tccttgtgtt gatatatcac tattgttaat 3824881 gactaacaca gaataccatc ctgcatatgc gtttttcctt tctggcactt ccgtagggca 3824941 tgcttcacaa atgatcctat tatggtttct tccgctttat tttttgttac tatgtgctga 3825001 cgattctata caagattata aaacaggata tcattacatt cttataagca aagttggcag 3825061 aaaaaaatat tgtttggaaa aaatatttac ctcttttatc atttcatttt tgacaatgtt 3825121 tttgtcacta atattaaact ttttattggt tcaggttttc ttttttaaag gtacatttaa 3825181 aaatgactta gaccaaatta aattccctga taacagcctt tatactttta gtatggccca 3825241 tccttatata gcaattgtgt tattttctat tatttgttgt attatgtctg gatttgttgg 3825301 agcacttggt tcaagcctca gtttactttt tcgtgataag aagtatgcct acccagcaag 3825361 tttttttatt tggttcgtac ttatactaaa aaacaaatca ttaatgtttt tattccaacc 3825421 gtttacagaa tacggttata atgtacttct ccctatccta tgtttgtcta tctttatttt 3825481 tctaataata atttctagta ttgttttata tgaggcaaaa tacaatgaaa attaaaagac 3825541 tactattaat tttatgttta ctactatttt tagttacttt atggttcaac cagaaccaca 3825601 cttatcttgg aaagaattct atcgcgtcat tactatatat gaataatagt acattcggat 3825661 atagttcaat atttgcatat accttgtttt atattgtccc gtttcttatg ttacttagta 3825721 acttttttca ttcagaaaac ccctacaaag taatgaggat ggttaagcgt aaaaattact 3825781 acaagtctaa aattatggag attgggtttg tttctttact tttttcttca atacatactg 3825841 ttattaatat tacgtgtaca catattttct ttagtaaaaa cttgttggtc gaagcaaact 3825901 ttttatcaat ttgtttatta aacatgatta gtttagtgtt tttctactta tcagtaggta 3825961 ttatgtttag acttacatac gatctgttta attcagtagc attagcaatt tttattgtgt 3826021 atataatttt agatagcttg tatttcggcg ttaaattatt acttcctaat ggatattggg 3826081 aaccctttag agacttggct atattcacaa atatgctcaa tagatattgg tcaacttcaa 3826141 atcttataat agtttatatt agacagataa taatagtttt tattttttat ttagttggat 3826201 cttcaatttt tttgaataag gattataaaa aatgaggatt aaaggctttt tcataacttt 3826261 agttgcgata atatttcagg cgtcattatc gagttataat aataataaaa atgtctttcc 3826321 ttttttagat ggcataccaa taagcacctc gggtcattat gagtatcaaa atattttatt 3826381 gtggtttgta cctattgttt ccctaagttt ttgtttctct gggagtatta gagatacata 3826441 catttcgtat gagcaattaa agttagtaag agaacatagt agagttaaat gggtaacatc 3826501 tcaattctta ataattacag ttgtactttt aatctttact ttatctcaga ttgctatatt 3826561 ttatatttat tcacttgtat ctcttcataa ccttgatatt aattccgtta tcaataaaag 3826621 atttgttatg atgacactca tgtattatct aaccttactt aacttattta gttttcaatt 3826681 atttatggag ctttattata aatctcaaat agcacaatta aatataagcg tttatattat 3826741 tttttcgtta attttagcaa agaagttagt gcaattaaat tctccgaaag ttattcacta 3826801 ctttttaatt ccaaactaca gtaatggatt aagaactggg ttaagctatt attcccaatc 3826861 tggaactgct attattgaac cattattagg tttgtttatt ataatcattt tacagatttc 3826921 aatagttata ttatctgtct taaagttcaa aaaaatagat atgctaaaaa gtgagggctt 3826981 acaatgattg aggtattaaa cctaacaaaa aaattaaaaa gactacagtt ttagataata 3827041 tctcttatac atttgaaaaa ggaacaattt atggactatt tgggagtaat ggttctggaa 3827101 agaccatgct acttcgtgca ttatccgggt taatagtccc tactgaaggg agtataacta 3827161 ttaaaggtga acaattacat aaagatatct cttttcctaa aagtgtagga ttaattatag 3827221 aaaatatgca gttacttcct cagtatgatg cttttactaa ccttaaaatt ttgtcaaaaa 3827281 ttaaaaagat cgcatcagat aatgatatat tagattctat tagtagagtt ggtttggaaa 3827341 attttaatag tgtaaaggtt agtaaattct cgttaggaat gaaacaacga ttaaatattg 3827401 cacaggctat ttttgaaaaa cctgatatat tgctacttga tgaaccaaca aatgcgattg 3827461 atgaaaaagg agttgcattt gttcatgaca ttcttttaca agagaaaaaa aggggagcta 3827521 ccattattat tactagtcat cacaaggaag atattatatc tttatgtgac attgcattag 3827581 aaatgaatca tggacgtcta gaaacttcag aaaaagtaat atataagaaa gatagttagt 3827641 ttaaactggc tatttcttat ccaatgatag actgcagaca agttcaactg ctgtaatgct 3827701 agaaaatcca atgaaatgct gataattgcg aagagatatg atcagtcaga aaacaaatct 3827761 taaaaagaaa aagtaaattc atcaatattt ctaataaacc tggcaaacaa cctgttcgga 3827821 ggcattatag ctacttcact gacgggatat ttatttgatg tgacaggctc cttacgctca 3827881 gctttctggt gccggttttg tgttgttgct gggattggtt ttttatgtgt ttgtattagg 3827941 ggatgtaaaa cgaattaaac tggaataaag agtgcttgct gaaaagcact ctttttctgc 3828001 atcgaaagaa tacttaagat aagtcactcc caaaaatcgt aacagtctga cggttaaaca 3828061 taaacctctg cccgttccat tttaatacgg tttgaacata tcccaatgag tcggcgttat 3828121 accttcccgc tatccgctgg tacgccaata attcgtatac gccgtctctg tcaaaatcaa 3828181 ccggatacaa gcccgataaa ggattcaccc atccttctat cggcattttt aacacacctt 3828241 ggctgttata aatctcattc aaatattccc tgcccttgta agtaaggtcg aggatatacg 3828301 tttcgttttg ctgatgactg ataacgctcg ctttatattg attttgatac ctcacactgt 3828361 actttaattc atcattcaat acatctgaat tgaaaattcg ccggaactgc ctgtttagat 3828421 aggcaaacac atatgcataa atagcaccgc cgcttccccc tgtgtccatt actactgcca 3828481 catcctcaat cttgtcgcct gtcatatccc ccagaaaaag tgacggattg tatcccatat 3828541 tgttttgaag ctgaatccgc tgctcctgat gggttctgcc atcacggatc accaatgtga 3828601 tatttctcca taacgggctg ccgggcattt gatttccagt tagaaagacc tcgtcaataa 3828661 cgccgtctcc cgttacatcg ccgcgggtag atacaatgat tgcacgtgag gagacaggct 3828721 gccgaaatac gtatggatgt tgaacaagtc ctctgccttc ataaaaccaa taaggagcca 3828781 ttctgatgtc atacacattc aattgtgtca ccttccctaa tcagctgaat gaatcattat 3828841 atgcaggaat ggcacatcaa agacatatct tacacaccaa ttaaatccgt accatatgaa 3828901 ttatcaatta cacaaagcca ctcgccttgc gcattctttt taaatacata ggtcgccctt 3828961 ctttccatcg catactcgga gtccttttta tccgaatcaa gcagtgtctg agaaagaacg 3829021 agtaccgtgt cacctgcttc caacaggatc attttccctt gtgtcgggac aatatgatga 3829081 ttgaaatagt tcgcaatcgt gataaacgct tttttgattt cttccttgcc tcgcgcgatc 3829141 atgcccggct tcacaactaa aacggcatct tccgaataat aattcatcag tgtatcaaaa 3829201 tcttcatttt ggattgccaa atcacacgca gagatgatgt ctttcaattg ctgttccaaa 3829261 tgaattcccc caatcatcat gattggatat attatacatc gctagaccac tgaaaccttg 3829321 aaaacaaaat gaaaagtatc cttttttcct atataatcaa atagatatat ttaacaaagt 3829381 acccaagtga aggggtgaac attattgtct gcggaagtaa cgttacatga caatatacat 3829441 tatgatttaa gtgcggattg ccagcactgt tttggcctgt gctgtgtcgc cttgccttat 3829501 gcgaagtcgg cagattttgc ttttgataaa gacgggggca cgccttgccg caacttacaa 3829561 tcaaactatc aatgttctat acataaagat ctcagagaaa aaggatttcg aggctgctct 3829621 gcatatgaat gctttggcgc cggccaaaaa gtatcccaaa tcacttatga gggaaaggat 3829681 tggcgaaaca gccccgaaac ggccaaccag atgtttgacg tttttcctat catgcagcag 3829741 ctgcacgaaa tgctctggta tttacatgaa gctctttcta tagatatagc caagccgatt 3829801 cattctgaac tgagaaccac tttcgaaaaa atagaaaggc tcaccagact cagcaaagaa 3829861 cgcttgctga cactgcaggt ggacgagcat cgagctgagg tcaatgaatg gctgttaaaa 3829921 acaagtgaac tggtgcgtgc ccaagcccgc catccaaaac tcccgaaaaa ggtcagccgg 3829981 ggaagtgtcc tgatcggcgc gaaactgaaa gggcttgatc tgcgaggagc aaatctaaga 3830041 ggggcgctgc tcatagccgc cgatctgaga aatgccgatt tgagaatgac agactttatc 3830101 ggtgcagata tgagagacgc tgatctcagc ggcgccgacc tgaccgggag catctttttg 3830161 acacaggcac aggtgaacgc cgccaacggc gattcgaata caaagctgcc gctgtctgta 3830221 cgaacccctg cccattggaa ataaaaaagg acccgctaac ggtccttttt tactgatcaa 3830281 ttcaatcctt tttcgttcct cttatccggc attttcacac ttcttgccaa gtatcccgac 3830341 agccataacg caaccagcag catgaaggtg atcataccga cgacgcccag ccagtgaaaa 3830401 ccagaccaga atagccctcc gattgttccg aaaacacttg aaccggcgta ataaaagaac 3830461 aaatacagcg atgaagcctg tgctttgttg tgaagggctc tcctgcccac ccagctgctg 3830521 gcaactgaat gccctccgaa aaaaccgaat gtaaagaggg caatccccag aattttcact 3830581 gccagcatat tgtttatcgt aaataacgca cctgcaatga cgatgaaaat attcatcacc 3830641 aatattttcg gatagccata ccgatcaacc attcttccaa tgaaagacga gctgaaaatg 3830701 cctacaatca tcacaataaa gatccagctg gaaaatgctt tattaagcga atacggcggg 3830761 cccaacagca catacacaat gtaattaaac aaggcaacat tgcttccaag cagcaaaaaa 3830821 ccaatgagaa acaagctgaa tagtttacgg tccctcaagt ggccgatcag agacattccc 3830881 aatttcccga gcttcaattt tcttggcgta aaatgcctgg atggcggcaa atttataaaa 3830941 aatataacac tagcaatcaa actaatgaca ccaattgtcc ccatcgccat atgccaattc 3831001 aagtactcgc tcaggagccc ggaaacgatc cttccgaaaa cggcgccgat tgcatttccg 3831061 ctgatatata gccccatcgc tgatccaaga cttccgggtt caatttcttc cccaagataa 3831121 gccatcgcaa tcgacggaag gcctgcgagc gcaacgcctt gaatggttct caatacgagc 3831181 agtgtatgaa agctcggact aaaggccgat gccagacaga gaaccgatgc ggccagcatg 3831241 gaaataccca taataggctt gcgtccccac acctcggata atgaaccaaa gacaagcatg 3831301 ctcacagcta acagcattgt ggtaacagat aaagaaagac tcgccgcagt aggcgttaca 3831361 tgaaattccc gcgtgaattc ctccatgagc ggctgtacgc aatatagaat cgcaaatgta 3831421 ttgaaacccg cagcgaagaa agcaaacgta atttttcgaa aaaccggtgt gccttttcga 3831481 atgtatgtca tcgggacttt atcggtccct catcatgttg tggagcactg ccattcataa 3831541 acaatcatcc tttatttctt acgaattcaa acatcctcga gtctgtttat attattatct 3831601 tagcaccgtt gatatatgtt gtataatgca tataaaatat ccttttcatg cttatatgta 3831661 ataaggagag atgataattg gaatgggaac aacttgaata ttttcaaaca ctggcccgga 3831721 tgcagcacgt cacgaaagcc gcaaaaagcc tctccatcac acagcctgca ctttcacgct 3831781 ctatcgccag gctggaaaat catttgggcg tcccgctatt tgacaggcaa ggacgatcca 3831841 tcagcttaaa tcaatacgga cacatttttt tacgacgggt tcaggcgatg atgaaggagt 3831901 ataccgaagg aaaagaagaa atccaagcct tattaaagcc agaccaaggc gtagtctctc 3831961 tcggtttttt acatacatta ggcaccacgc tcgtgcccga tctcatcggc tcctttcagc 3832021 aggaataccc caacatttcc ttccagctga agcaaaacca ctcttattgg ctgcttgaac 3832081 gattaaaatc cggagatctg gacctctgtc tcctcgcttc gattaagcct gaaaatccga 3832141 tccaatggat caagctgtgg agtgaagaac tctttgtatt tgtgccaaat gatcacccat 3832201 tagccagtcg cgaaagcatt accctgaatg agattgccgg ggagcgtttt attttattga 3832261 aaaagggcta tgcgcttcgg atgacggtcg atgagctgtt tgagaaggcc aatatacagc 3832321 cgaacattat gtttgaagga gaagaagcaa ctactgccgc aggttttgtg gcagccggtc 3832381 tgggcatatc tattctccca gacctgaaag gcttagacca aagcaaaatc accaaaatcc 3832441 gcgtcagctg gccggaatgt cagcgtgtca taggaattgc ctggataaaa ggcaggtttt 3832501 tatcaccggt tgctgagacc tttaaacaat atgtgatcag ccatttttct gagtaggaag 3832561 gattcaagca tgaatgtcaa aaaaatcacg tcagaacagg atttacatac agcgtttgaa 3832621 atcagaaagg cagtatttgt agaggaacaa ggctgtccca tttcggatga attcgatgag 3832681 ttcgatacac tccacggtga ctgccagcac atcctggctt atcatcagaa tgtacctgtt 3832741 ggcactgcac gtgtccgtat cgttggccac acggggaaac tggaacgaat ctgcattctg 3832801 aagtcttacc gcaaattcgg tttgggaaaa gtgatcgtcg atgcattaga acgtattgta 3832861 aaagaacaag gcatttctgc cttcaaactg cacggccaga cacaggcggc aggcttttat 3832921 gaaaagctcg gctatcggac tgcatcagaa gaatttatgc tggacggcat tccgcatgtg 3832981 ctgatgacaa aacaagacga ttctgcgcta tagattgttc acaaatttgt cacttatgag 3833041 catgaacggt tcattggtat actaatcacc gattatggag agaaggaatg attgtatgcc 3833101 agcaaataaa aaagaaggcc ttatatttgg cgtgatgatg tgctttggaa tggtttgcgt 3833161 catgtcgatt tacaatgcca tcatcaaccg agccatctac gatttttcac tgatgaccgt 3833221 ttttgaaatg gtcatcggtt ttatgatcgc cctcctgtta gatttactgt tagtgggccc 3833281 cctcgccaag aagattgcat tccgcatgcc gttcgacaag actaaaaaaa tttatgtcat 3833341 ccttgccatg tcaacttgta tggtgattgg catggtactt tgtatgtctg tgttcggttt 3833401 agtgacagcg gttctagcaa atgggctgaa cggggacagc ctcttcagtg cttatcttat 3833461 gattgtgttg aaaaatttca tcctggccta tccgttgcaa ttactgatta tgggcccatt 3833521 agtcagagga gttttcatga aatttgtaaa accaaagctc acagccgcaa tttaaataga 3833581 aaaggagtga gcctgacact cactcctttt gctcatgaat cgaatgtaaa acaagctccg 3833641 caaaagcctc tgcggcaggc agctgccatt ttttcttttt gggtgtgagt aaatcggatc 3833701 gagggcttca ccatgctgga gatttttcag cttatgtttt tcacttccat taatccctat 3833761 accttaccac atagttttta tacaattctt cgttataaag gatttcttcg ccatgtgaag 3833821 agcaaatgag cgttggtttg atttgatcta tgattgagcc gctgtcgatg ttctcattta 3833881 tatcaacact gaatcttctt ataggtgggt gtaaatcctc cttacttgtg ataaaaaggt 3833941 cgcccgtcaa tagcgtacga tcgattttat gataatacac aacatgcccc ggcgaatggc 3834001 caggtgttaa atagtatttc agaggcagat gagcaagcgt ttgctccgtc agcggctgta 3834061 caatatgggc tacccctgtg ttctccactt catttttgtt cggatatggc tcttccccat 3834121 tgatgtactt tagttctttc tggtgcgcaa aaatcggaat atcaaatctc tctaaccatt 3834181 ttgatgcacc cccgatatga tcactgtggc catgggtaag caaaatggct tttggattgc 3834241 cgatcgctaa cgctgcccta atttgagcat cagcaaaacg ttctattccc gtatcaacaa 3834301 tataaacatc atcaccatct ttgataaacc aggtatgaac cggaatacga agaggcacat 3834361 caagctcaaa ttcacattga aagacatgtt ctgatagttg tctcaaattc acgcaaacca 3834421 tctcctgtgg aaattttttg atagttttaa agaaaacaga agtgaacgga ctattttcac 3834481 ccacgctcga gctgactgga ttcttgagag gaaacgccga ttttcgccag catcagctca 3834541 acttgttaac gttgtccatt aataatccct tttgttcccc ttcttcacat attcccaatc 3834601 acgttctata ttcttcctca ctctatgaag gagtgcagaa atggtttcct tttcctctga 3834661 agtaaaaccg gacaaggcca cttccgtgga atgttctcct tctcttctta acaatggata 3834721 tacctttttc cctttctcag tcgggaacag tttttttatt tttttatttt gctcatccgg 3834781 cagtttttga ataaatccct gcatttccag cttcttaatg gcccgcgcgg ccgttgtccg 3834841 gtccactttt atcatttccg ccaatttttc ttgaataatt cccggatttt cgtatatacg 3834901 cacgagatag agatactgcc ctcttgttaa gtctaaatct ttaaattcga tgttgcttat 3834961 ggaatccaac gctcttgcta tcatgccgat ctcacgcaaa atatcattca ttcctaaaac 3835021 ccctcacgta tttttgttgc aattacaaca aaaatgtttt aaccttacta ttataagacc 3835081 acatgcgtgc tgtacagtcc agactaatat cagaaaagga ttgattcata atgaatataa 3835141 aaagaataac aactgaagct gatttacatg aagctttaaa gattagaaga ggcgttttca 3835201 ttgaggagca acatgtgtct gaagccgatg agttcgatga atttgatacg cttcaggaac 3835261 aatgccagca tatcttggta tatcatgaga atcagcctgt cggcaccgga cgcgcgcgca 3835321 tcgttggcca tacagcaaag ctggaaagaa tctgcatcct aaaaccttac cgtaagtacg 3835381 gattggggaa gatcatcgta agcgggttag aggaaatcat gaaagaaaaa ggactgactt 3835441 catataagct gcatggtcaa acacaagcgg caggctttta tcaaaaactg ggctaccaga 3835501 tttcttcaca ggaatttatg gaggacggca tccctcacgt cttgatgaca aaagaaatat 3835561 cgcggaatat aacatgaaat atatgtatta cggaataggc atactcatat taagtttggg 3835621 catttcctta accatacaat caggactggg cacatcaccc ttcgatgccc ttttggttgg 3835681 tctgtcaaaa aaaatcggtc ttaccgtagg aagctgggag gtccttattt ctgtgatcct 3835741 cttaatctgc aacgctatat taacgagaaa aaaacctatt ttgctgggct tgattacagc 3835801 attcattact ggaataggca ttgacctatg gttgtttgtt gtaaaaaaca ccatctatct 3835861 aaactcgttg ttaagcaaac tgatttgttt tggaattggt ttggtgctca tcggtcttgg 3835921 aacagccatc tatcttcaga cgaaattcgc atcaacaccg atcgatcatt taacacttat 3835981 tatccgagat ctctccaaaa gaacaatatt gttttcaagg acattggtat acgctctttt 3836041 cttagtatta gccatcatct ttaaaggccc tatcggcatc ggaactcttt taacggtttg 3836101 tttgggagga atgctccttc acgtttttat gcctattgtg gaaagacatt tcttatcaaa 3836161 gaatagaaga ggttattaag aaacctcttc tcgatccaaa aaacgaaacg caaaacaagc 3836221 cccgtttcgt tgtcaattct ttatctctgg tactgttgag gttttataat caattaaaat 3836281 ttatagtacc aaaaaatcgc aatttcattt gctgttggaa agttggaata aagcatcgta 3836341 tcaaccgcac ctattataaa gtgatgtttg gcataaaaat gacaagctga aatattaata 3836401 tcttgggttt caagcataag accacaaaaa tgattctcct ttgcccactc aatcgcttta 3836461 tgtaataatg ctgttccaac accttttttt ctatagtctt ttgccacggc aatgtcctct 3836521 attagtgcat acccattcca gttagaacgg atcttaatcc ggccaatgca gttgttttca 3836581 agataatata aaaaagccgc tttcccctct tcttcaacat aactaacatc catgtcatca 3836641 tcttcatatt gtttaaaata aggtttagaa aatcgttcct cagtatatgt ccaaacaccg 3836701 ttttcaaaag caggtatcat tctcccaaaa acaacgaaag gttcgtttgg tttattgaaa 3836761 tctttcatat tcaaatgagt cattttcatg atcatatcaa tctccgccaa tcgagataat 3836821 atttagtaaa ctcgtttcga tactattcaa caacagcttc caaaagtgta ctctttaaga 3836881 gaacagcatt agataaggca tccattacct tatatatttc actatcttaa tgaggtattt 3836941 caacagaggc ttgtggtaca gtaaaaagga atagaaacaa gagaaaagaa gatgaaccta 3837001 tgcccactaa caataaactc aatgagaaat atcatacttc cttcaactcg cccacaaccc 3837061 tgttgactag tatccgtgga gagaggaagc tttgacacag cttctgccat tgatgacatc 3837121 tctattgaag tatccaaagg acaaccaagg atcgctcttt gactttttca agaagaaagt 3837181 agagtgaata aaggagtgat tgagtatgtt aacaagagaa gatatcttta aacacgtcaa 3837241 agaaaaatac ggtacatcgc ctgattaccc gtgggagaaa tacccaaact atgcttcttt 3837301 gagacataca tcaaacaaaa aatggtacgg tcttatcatg aatgttctcc cagaaaaatt 3837361 aggcttggat ggtcatggcg aaatagatat tctaaatcta aaatgtcccc ctgaaataag 3837421 tgatcgctta agaaacgggg aaaatatctt acccggatat catatggata aggaacattg 3837481 gatttcaatt gttttagaac ggacagatcc agaaggcgaa atctataact taatcgagca 3837541 gagctttcat ttaaccaagt gaagataaag agtgttcctg ctaatcaagc tgcgaagagt 3837601 agtgggcact ttcattttag gatactgttc ttcactctgt ccacaaacgc aacttagttc 3837661 atctggtgcg agagtgggag aagaatttca accaacttct tatgtaaaag gatgaatagt 3837721 tatgacaaat aacttaaaac agagaagaat cattttagat ttagcagtta ctttagatgg 3837781 ttttattgaa gggaaaaatg gagaagttga ttggtgtatt atggaccctg atatggggtt 3837841 tactgatttt ttaaatcaaa ttgatactat tttatatggt agaaaaagct tcgatttatg 3837901 gggacaatac attccaaaaa atgaagaccc tgatacagaa aaggaacttt ggaaattggt 3837961 tcatagtaaa aagaaatatg ttttttccag aacacaaaat gagattgata atcaagccat 3838021 atttataaat gataatattc ttgaagaagt aaataaattg aagaaaaatc ctggtaaaga 3838081 catctggcta tatggtggag cgagtctcat tacaactttt ataaatttgg ggcttgttga 3838141 tgaatttaga ttatctattc accctgttgt tttgggagaa ggaaaaccgt tgtttattga 3838201 tgtaaaacag aggataaatt taaaaatggt gaatacaaga acattttcct ctggcgttgt 3838261 gcaaatcgtt tatcattgga atggctaaca ttgtaaagta acactcgaca gtaatccttc 3838321 ttattgaact aaaggggaat ccataaataa tgggttcccc ttaatatact atggaattat 3838381 caatatcaaa ttttctgtaa taaaagagga ttgaaaagga cgatgtctcc tcaattaaca 3838441 tcattaagca ttatagtata ttttcttctc cctcttttaa gtaatcggct aagttttgta 3838501 tttataaaaa aacgaaagaa ggtgatccaa tgcctactaa caataaaccc aatagattaa 3838561 tcgctgagaa atctacttat tttacttcaa catgctcata accctgtgga ctggttccct 3838621 tggggagaag aagcatatga aaaagcgaaa cgcgaaaaca agcctgttct cgtatctatt 3838681 gggtatagct aacgatggct aatctaaaga acatgctatt gatgccatgt ttattcattt 3838741 tacaaaaaag gatcaacctt gaattacttt cacaagattg atcctttcac tcatttagcc 3838801 atgtctccgc gaacgtttat atacattcaa gattactagc caacaaataa caatgattcc 3838861 tgcaaaaagt atgagcatat tgctatacaa ataggtagag tgatcaacgt caataggcag 3838921 cagcctatga tctaggaagc cgatagataa taaaccgcct acaatcgcaa tacccgttcc 3838981 ctctgataaa aagctcgtga aattaagcaa actcattcca gcgcccgctt ccttttcttt 3839041 caaactgcta gacacaactg tagatataac tgtttttgtg aaagatagcc ccccaaaaac 3839101 aaaaattact ataattgtca tgatccatgg tgctgcatct ataaaaaagg cagcgattaa 3839161 aaagccggaa gaaagcaatg cacttccaat agttagtaca tacaaggaac ctttccgatc 3839221 aacaagcaat cccccaatgt aaccaaagat gatgacactc attgttccgg ggaaaataat 3839281 gccgcttcca attgctgcag tacttaaatg gtgaacatct ttcatcatgt aaggaaccat 3839341 agagacaaat cctgctactg taccaaatat tagtcctccg caaagggttc caatcacaaa 3839401 aaagacgttt ttccctaatt cagggtcaac aaaagggtcc tgagctttcc taatgtgttg 3839461 cacaaatatg aagaaagcaa ggatactgat gatcagaaaa gaaaatctat aagatgttgt 3839521 aaacagcata aaaaatacga tacctgcaga catcaatata atccctgcca tatcaatgtg 3839581 tcctcttatt ctctcttcct ttttcaacaa ttttataagg aatggaacgg tgataattgt 3839641 tgcagttgga ataagcagca aatacgacca atggatataa tgagcaacca ttccgccaat 3839701 agctggccca acaccttctc ccattgctac cagggacccg atcaggccaa atgctttccc 3839761 cctgttctct tttggaatat agcgcgcaac gacaaccatc acaagagctg ggaatgcggc 3839821 tgcaccaatt ccttgaataa atcgggctag aatgagaata ggaaagaaag agtgtccaac 3839881 aaatccaatg atcgacccta agccatttac cataatccca aatagaagca gatttttgat 3839941 gcccagctgg tctgatagct ttccatatag agctgttcca atggagaagg ttaacataaa 3840001 ggctgtattc acccagtttg cacttgctgg cagtttatta aactcgttgg caatatcagg 3840061 taatgagacg ttcagaacca tttcatttaa tacgctgaaa aatgatagaa cacaaagcca 3840121 aatcaaaact tgattgtgcc gtaaagttga ctgtgaataa gacgtattca caatttcccc 3840181 tccattaatg agggcagacg cagtttatag ggtcattgat acgcttccct cttttaattg 3840241 taccctgttc attttattgc acttcataat aactccccct acatttgatt gatatgatct 3840301 tattatatat agactaagga ttaaactttt acttttttta taaaaatttg accagattgc 3840361 gaaacaagga aaaacgttat tcgcatttat ctcaagtggc aaaatgaaac attagtttat 3840421 attttcacat cacaattatc gataagcagt cagttattgt atttgtttag gataactgtg 3840481 gtaacctgaa tataaccaac ttaggaagaa ggtgatccca tgccaaataa aagtaaaccc 3840541 aatagattaa tcgctgaaaa gtctccttat ttactccaac acgcccacaa ccctgtggac 3840601 tggttcccgt ggggagaaga agcatttgca aaagcaaaac gcgaaaacaa gccggttctg 3840661 gtcagcatcg gttattcgac gacttgtcat tggtggcctg ggataatcaa atcgtgtgga 3840721 actccattaa aagataacag aagccatttt aaacgataat actatttgtt caaacaatac 3840781 agtctacctt ttatttcatt cattttctaa aacctgtaat ccgtaaccac gcggtagcag 3840841 gtttttttat ttgcttgact tagagttaac tctaaattgt aaactaactt taattaaatg 3840901 agagggatga tgttgttgta ttccattagt aaagctgctg agaagactag tattagttcg 3840961 tatacattaa gatattacga aaagattggg ttacttccac caccaaaacg aaaaaacagt 3841021 ggaaggcgtt tttatacgga gactgatatt cagttcatgt tattcctgaa aagtttaaag 3841081 gaaacaggta tgtctttgga ggatattaat gagtttgtca aagacggatg cattttggaa 3841141 aaaatcaatt cggatgttaa atcggcacaa ctctccccat ctataaataa acgtattgag 3841201 attttaacca agcacttaga gaaaatggaa attaaaaaaa gggagctgga agaagtgatt 3841261 tctactacaa aaggaaaact ggatacatat tattcaattt tgaaagagga agtggaaaac 3841321 aaatgaaaca tttaaatata tacataatgt tacttggctt ctctattttc acgggagcta 3841381 cttttaatct tgcaaaatat acagttggat atttttctcc atcgtcttct gcggcatggc 3841441 gtttcggttt agcggctgca gtgatgctca tcattttgat ttttactgaa ggtataaaga 3841501 agagtcaatt acggaaaaac gccgtttcat acattgttct tggaattata ggaatctttg 3841561 gatttaatgc cttgtttttt gttggtttaa aatatacatc tcccgttaac ggagcattaa 3841621 taatggggct gaatccttta ttaacagcaa ttctcgctcg aattatctta aaggacaaca 3841681 tgacaaaaaa acaagtactc ggcatattct ttgcattcat cggtgtattg ttagtcatta 3841741 cacaaggttc tatcgaaacc attaaaacct tatcaatttc aggaggagac ttaataatct 3841801 ttacaggtaa cgtttgttgg gcactttatg gcgtacttgg acgtcggttt gtaaaggatg 3841861 gtacaccgct atctacaacc acttatacga tggttattgg tgctgttagt ttaatagtag 3841921 tttccttatt tacatccaaa cctgtttctt tatcgaacat cccgattgga gtttgggggg 3841981 caattgcttt tatggctttt tttacaagtg ttttgggtta cctatggtgg aatcagggga 3842041 ttaaagagat tggagctagt aaaacatctt tatttttcaa ccttgttccc gttgtaacga 3842101 tgattatttc atttgccgtt ggaacaccaa taaaggtatt tcaagttatt ggggctgtgc 3842161 tagttatatt aggcgtttta accgcttcgg gggtaatacg tattcctaag tacaatacta 3842221 aagaacagtc agctatataa agaaataggg agtatttttg agaaaatgtg ttaagttaaa 3842281 tatacactaa ttataggaag aaggtgatcc catgccaaac aaaagtaaac ccaatagatt 3842341 aatcaatgag aaatcaccat atttactcca acacgcccac aaccctgtgg actggttccc 3842401 gtggggagaa gaagcttttg aaaaagcaaa acgcgaaaac aagccggttc tggtcagcat 3842461 cggttattcg acttgtcatt ggtgccacgt gatggcccac gaaagctttg aagacgaaga 3842521 aatcgcgcgt cttctcaatg aacggtttgt ggcgattaaa gtcgaccggg aagagcggcc 3842581 tgatgtggat tctgtttata tgagaatctg ccagctgatg accgggcagg gcggctggcc 3842641 gctgaatgtg tttatcacgc ctgatcaaaa gccgttttac gcgggtacat attttccaaa 3842701 gacgagcaaa ttcaatcgtc ccggttttgt tgatgtgctt gagcatctgt ctgagacgtt 3842761 tgcgaacgac cgcgagcatg tcgaggatat tgcggagaac gccgctaaac atttgcagac 3842821 caaaacagct gcaaaaactg gtgagggcct tagcgaatca gcgattcacc ggacattcca 3842881 gcagcttgcc agcgggtttg acacgatcta cggcggtttc gggcaggcac cgaaatttcc 3842941 aatgcctcat atgctgatgt atttgctacg ttatgatcac aatacagggc aggagaacgc 3843001 tctatacaac gtgacgaaaa cattggacag catggcgaat ggcggcattt acgatcatat 3843061 cggctatggg ttcgcccgct attcgaccga tgacgagtgg ctcgttcccc actttgaaaa 3843121 aatgctgtac gacaatgcgc tgctgctgac cgcttataca gaagcctatc aggtcacgca 3843181 aaacagccgc tataaagaga tttgtgagca gatcattacg ttcattcaga gggaaatgac 3843241 tcatgaagac ggaagctttt tctcggcttt ggacgcggac acagaaggag aagaaggaaa 3843301 gtactacgtg tggtcaaagg aagagattct aaaaacgctc ggggacgatc tcggaacgct 3843361 gtattgccaa gtgtatgaca tcactgaaga aggaaacttt gaaggcaaaa atattcctaa 3843421 cctcattcac acaaagcgag aacaaatcaa agaggatgcc gggttaaccg aaaaagagct 3843481 cagtctcaaa ctcgaagacg caagacagca gctcttgaag acacgcgagg aaagaaccta 3843541 tccgcatgtc gatgataaag tgcttacctc atggaacgcg ctgatgatcg cgggtcttgc 3843601 gaaagcggca aaggtatacc aggagccgaa atatctcagc ctagcgaaag acgccatcac 3843661 atttattgaa aacaaattaa tcatcgacgg ccgtgtgatg gtccgatatc gtgatggcga 3843721 agtgaaaaac aaaggcttta tcgacgatta cgcttttctc ctatgggctt atctggatct 3843781 ctatgaagct tcgtttgatc tttcttattt acaaaaagcg aagaaactga cagacgatat 3843841 gatcagctta ttttgggatg aggagcatgg cggattctac ttcaccggac acgatgcaga 3843901 agccttaatc gtacgggaaa aagaagtgta cgacggcgcc gtgccttcag gaaacagtgt 3843961 ggcagctgtt cagctgctgc gtctcgggca agtcacaggc gacttatcac tgatcgaaaa 3844021 agcggaaaca atgttttccg tgttcaagcc agacatagaa gcgtatccga gcggccatgc 3844081 tttctttatg caaagtgtgt taaggcatct gatgcctaaa aaagaaatcg tgatttttgg 3844141 cagcgcagac gatccagcca gaaaacaaat tatagcggag cttcaaaaag cctttaagcc 3844201 caacgactcc attctggtgg cagagcagcc cgagcaatgc aaagacattg cgccatttgc 3844261 agcagactac cgcatcatag acggcaaaac aaccgtttat atttgtgaaa acttcgcctg 3844321 ccagcaaccg acaacaaata ttgaagaagc gatccacaca ttaataagca gcagggatta 3844381 agacccttgc tgcttacttt ttgatttctt atggtaccat aaagcgatcc ccgcaaacac 3844441 aaggttgacc gctatcgtaa agaaagcctc ccacatcggg ttcccccgcg taacggtaaa 3844501 cagagaagga attcctccat acacactgtt tttttctgta ataaacatac acaaaaacat 3844561 attattcgcg gcatgggcgc caagtgatat ttcgatgctc ccagttttaa tcgtgtaata 3844621 cgtccacaca aacccaaatg ttaagtactc aattcctgcc cagacagcgc cattgttcat 3844681 ttctggattc gcaaaatgca atacgccaaa caatcctccg acaatcagtg tcaaaaatag 3844741 aggatttttc gtcaatctcc cgaaagcttg aagcaaaaat cccctgaaaa atagttcctc 3844801 agctgatgtc tgaatcggaa ccaaaatgag ggcagccgct agcagccaga taaatcgtga 3844861 tgcattaaac tcttgcattg aatagctatc aggatgaatc acaaaatcaa tcaattgtac 3844921 ggcgatcatt agcaagaaat aagcaataaa accaaaggaa attctccgcc aattcatctt 3844981 tgaatttggt gttatcaccg ttcggaaagg ccgcttcaaa ataaagcgca cagccagcca 3845041 aactcccgga atggcgaata aataaatcac atgggacaaa taaagatcta cgaggggatc 3845101 actcagcaca gcttcatcca aatcaaacgt gatattggga ttcacaataa ccgtgaacaa 3845161 tatagcgaaa aggtaagcta tattccctaa tacatataac cctaccatca ccaaaaaagc 3845221 gaaaaaatat ctccacaacg tattgtttcc ttctatagga cggataaatg aattcattcc 3845281 ttctatgtct cttcctttca atgagaatat tactatatat ttgcataaat tggtctatga 3845341 atctactgtt ttggaaatct tttaagcaaa attaaaatat aaagtgtgaa tttagttctt 3845401 ccatctagtg atttgaactc tgttgccaat gaaccaagat acttataata gtcccaagag 3845461 gggaattttc agtcttttct actactcaaa agggggtttt ttatgaatac gatcttcaaa 3845521 caaaagaata cacatccttt ctcaaacgca gcgaatcgtt tagaccgcct tccgatttca 3845581 cgcgttcatt tccaagtgtt aaccgctctc ggcattgttt atttctttga tctcgcagat 3845641 ttatttaccc tcagcaacgt agcgccggca ctgatcgagc attggggcat cccgctttca 3845701 actattgcta acgtaacggc cgcttcgttt ttaggcatgt ttttaggcgc ttcactgggc 3845761 ggacggctgt ccgatcgaat cggccgcaaa aaagccttaa atctatttgt ctttgttttc 3845821 tcaatcgcat cgctatgcaa tgctgcggca tgggacattc catctttaat gacattccgt 3845881 ttcctcaccg gatttggcgt tgcagccgcc atggtcatta cgaatagcta tttggcggaa 3845941 tttttccctt caagtgtacg tggaaaatat atttcttttt gtgccatgat tggattgatt 3846001 ggggttccga tcaccaacat tgtgtctgcc tttgtcattc ctcttggttc atggggatgg 3846061 aggctagtat ttgtatgggg tgccgtcggc cttatttatt ttttcttcat ccaccgtctg 3846121 gaagagtcac ctcgctggca cgaaaatcgc ggggaatatg cgaaagccga tgcgatcctc 3846181 acccgaattg aagaacaggt tgaaaaggag aaaggcccgc ttccggcagc atcccagcct 3846241 aaagtaagcg aaactgttaa gcagaatgca ggttacgcag gcttattgaa aggcagaaac 3846301 ctcaaaatta ccatcgtatt atctgctgta tggatttttg aaacgtttgg gttttacgga 3846361 tttgcttcat gggttccaag cctgctaaaa agcaatggcg taaccatgga aaatacatta 3846421 tggtataacg tattgcattc cgtcggcgct ccacttggcg cactgctcgg ctccatgatt 3846481 tccgaaagat ttcaaagaaa atggatttta gctgcgagtg cgtttctgac ggccatcgcc 3846541 gggctcttat atggtatgac ttttattccc atcatgatca ttgtatttgg ttttatcgtg 3846601 aatatcacag aacgggtctt tacctcgaac ttatacgcct atacatctga accttatccg 3846661 actgaatacc gctcgtctgg cagcggttta gcctatggtc ttggccgttt ttcaaacatt 3846721 tttggctcat tgcttgtcgg atttattgcc gttcagctcg gctatatcag cgtcttctta 3846781 tttattgggg gctgttggct cgcatgctcc ttgctgttaa tcttcttcgg tcctaatacg 3846841 aatgcaaaac agatttaaaa aagtcagtgc ggatctgccg cactgatctc attacaattg 3846901 cttcaaaatc cttgcggggt ttccgcctac aacagtatta gcgggtacat ccttagtgac 3846961 aacagatcca gaagcaatca ctgcgttatc accgattgtc actcccgggt taatcaccgc 3847021 ccggcctcca atccaaactt gatctccaat tgtcacaggc ttaccgaact ccttcccgga 3847081 tttcctttcg atcggatcaa gaggatgacc ggccgtgtag atatgtacac ctggcgcaat 3847141 caaacaatga cagccgatac gcacctcaca cacatctaaa atgacacagt caaaattaac 3847201 aaatgtatga tctccgatat gaatgtgata gccataatca cagcggaatg tcggcaaaat 3847261 cgtgacttga tccccaaccg aaccgagcag ctccttcaaa agcttcgtcc gcactgcatc 3847321 atcttccggt gtttcgttgt attgtctaat cagctgtctc gcatgcttgc gttctagtaa 3847381 tagttgttga tcttccgaat tgtataattc tccggctgcc attttttctt tttctgtcct 3847441 cagcatttaa gtcactccag atgtcagatt gtaatctcga tcaaatttcc ttcatcatcc 3847501 tcaatcacgc tttcatagta gccgtctcct gttgtcctcg ggccgtttac tactgcgaaa 3847561 ccatccgcct tcaatcgatc agtcagttcg tcaactttct cccggctccc aacggaaaag 3847621 gcaatatgtg cccagcctgt cattgtttgt gagggcggat cggtcacatt cccttttttc 3847681 ataatttcca gccttgctcc ggaatcaaac gtaataaaat aagacttaaa atcttttttc 3847741 tcattatgat acaaatcatt cgcttcgcca ttaaaatacg attcataaaa agacttcatt 3847801 cgctctaaat cattgaccca gaccgctgta tgttcaatct gcatttcttc ctcctccttc 3847861 gccttcaatg aagttataag gtatgaaatg catttcagtt caagcttttt tcttaaattt 3847921 atgctgaatt ttgatatcag cgggttcatc ctgcaaaaat agagaaaatg ctgcgatgcc 3847981 gagctgctca agattcaaat caagcgacgg aaaaccaaga acacggctga tagaagtatt 3848041 tccctcgcct atgatttcaa catcccaatt attctttttg gcaaatagat gaattccagc 3848101 tgccacttca tcactatttg cataaatagc agtcggaacc cgcccgctca tataaaaatg 3848161 ttcagctgcc agctcaccat cattcatatc gttgcatccg gacagcatat ggcggtcttc 3848221 caaccttccg cagacagctt tataggccgc agctttatca gccgtgctcg ggctcctatc 3848281 agcttctctg acacacgtaa aagcaatatt ctcatgcccg cggctcttta aatagcgaaa 3848341 gctctctgca taagcagttt ttctgtcatt aaaagcacaa gggacatcaa tgtctccggt 3848401 atcctcacaa gcgatgaccg gcccatattc ctgataagct aaaatgctgt cccaatgatt 3848461 ggcgcgggaa gtaatgatga gaccgtctat tttcttcgtt cttaacagct ctaaatattt 3848521 gatttcaata tcggggttat aattggtggg gagaagggtc gttgcatact catgctgaaa 3848581 agccgccttg gtgattccgt taacgatttt atcaaagcag ggatgatcgc tataaggcag 3848641 aatcacaccg accgtatggg ttttcccgcg aatgagatcg attgcggttc gatttggtgt 3848701 ataatccaat tccttcatga cttgatgaac aagctttctc ttttcttcag atacatacgg 3848761 atgatgattc aatacacgcg agacagtcga aacagataca tttgccagtc ttgcgatctc 3848821 ttttatattt gccatctctt tctccttttc atataaaaaa agcagtaagt gtaaaatcct 3848881 tactgctatc tcatcatata ttgatgataa gttcaacagg acaatggtcg gaacccatga 3848941 cgtccgctga tatgctggca tcttcaatct gttccttaag gctttcagaa acaacaaaat 3849001 aatcaatccg ccatccaata tttctgtccc gggcgccggc acgatacgac caccaggaat 3849061 aagcgccttc aagatcagga taaacatgac gaaaagaatc aacaaagcca gcttctaaga 3849121 aacgagtgaa tgcctctctt tcttgatctg aaaatccagc gttattccgg ttcgcctttg 3849181 gatttttcaa gtcaatctcc tgatgggcta cattcaaatc accgcataaa atcactggtt 3849241 ttttctgatc caattcaaga atataagaca gtaaagcctc ttcccattgc atgcggtaat 3849301 caatccgctc taatcccctt ctggaattgg gcgtgtaaac agtcatcaca aacacgtttt 3849361 caaattccag cgtaatcact ctgccttctt ggtcatgctc ttctactccg ataccgtaga 3849421 tgacctgcag cggttcttgc ttagaaaaaa cagctgtgcc ggaatatcct tttttcactg 3849481 cataattcca gtacacatga tagtcttcag gctggagatc aacctggccg tcctgtatct 3849541 tcgtttcctg aagacatata atatctgcat cctcttcttt caaataagag aggaaatcca 3849601 tttttctcat cacagcccgc aggccgttta cattccatga aatcaacttc atgtttcatc 3849661 ctccccccta taaaaaagag caagaacccg aaggtccttg ctctttacat atcagcttac 3849721 tcaccgctta cgtatggaag taaagccatt tgacgtgcgc gtttgatcgc tgcagtcaat 3849781 ttacgttggt atttagcgtt tgttccagtt acacgacgtg gtaaaatttt accgcgctca 3849841 gaaacaaact ttttaagaag atctacatct ttgtagtcga tgtgcgtgat accgttagaa 3849901 gtgaaataac acactttacg gcgtttcgca cgaccgcctc tgcgtcctcc tgccattgtc 3849961 atttccctcc tttctttttc attttaggcg ataatcacat tagaatggaa gatcatcatc 3850021 cgagatgtca atcggtttgc cgtcgttggc aaatgggtca tcattaaagc tgttcccctg 3850081 attgcgtctc tggttgtttt gatttccccc aaatggatta tcattttggc ctccgccaaa 3850141 gtactggcct ccgccgctgt ttccttcgtt gtatccacct gaaccagaac cgccgccgtt 3850201 tttcggctca agaaattgaa cactttcagc ttggacctct gtcacgaaga cacgctgtcc 3850261 ttgctggttt tcatagtttc ttgtttgtaa acggccatct acgcctgcaa ggcttccttt 3850321 tttcaagaag tttgcaacgt tttcggcttg tcttctccaa gtgacacaat taatgaaatc 3850381 ggcctcacgt tctccggact ggttcgtaaa tgtacgattc acagcaagag taaacgtagc 3850441 aacagccgca ccgtttggcg tataacgaag ctctgggtct tttgtcagtc ttccgactaa 3850501 tacaactcgg ttaagcataa gaaagaccac cttttaccat tatatatttc aaaattgctt 3850561 attcttcttc tttaacaaca atgtggcgaa tgatatcgtc actgatctta gctagacggt 3850621 caaattcttg aactgccgca gcgtcagatt gaacgtttac gatttggtag aaaccgtcgc 3850681 ggaaatcgtt gatttcgtaa gcaagacgac gtttacccca atcctttgtt ccagtgatct 3850741 ccgcaccgtt agaagtcaga acgttgttga aacgctcgat aactgctttt ttagactctt 3850801 cgtcaatgtt tgggcggata atgtacataa cttcgtactt tctcatctgt ttgcacctcc 3850861 ttttggacta agcggcccat aatgggcaag gagcaataat tctattactc acaattttat 3850921 attataccaa agctcttgtc cctttacaac tgcatcctat acattaaatc ggaaatgaat 3850981 aacatctccg tcttggacca catattcttt cccttcaagg cggacttttc ctgcctcttt 3851041 agctcctgcc ataccgccgc ccgcaagaag atcctcataa gcaactgtct cagcacgaat 3851101 gaagccccgc tcaaagtcac tatgaataat tcctgcacac tcaggggctt tcatgccttt 3851161 tttgaatgtc caagctctga cttcctgttc tccggctgtg aaatatgttg cgaggccgag 3851221 aagagagtaa gacgctttga tcagctgatc aagacctgat tcttgaatgc ccagctcttc 3851281 caagaacatt tgcttttctt cgccttcaag ctcagcgatt tcagattcga tttttgcaca 3851341 cacaacgata acttctgcgt tttcgccggc agcgtactcg cgaatcttcg ctacattttc 3851401 attgccagat ggatcagcaa cttcatcttc acttacgttg gccacgtaca aaataggctt 3851461 cgaagtcagt aaatggagct gcttcacaag cttttgctgc tcttcagtga attctacaga 3851521 tcgagcaggc ttttcactct caaacgcttc tttcagttta gataaaatct caaactcaaa 3851581 tacagcgtct ttatcttttt gcttcgcaag cttgctgacg cgtgtaatcc gcttttcaac 3851641 tgtttccata tcagcgagga tcagctcaag gttgatcgtt tcaatgtcat caatcggatc 3851701 aacctttccg gaaacgtgtg taatgttgtc atcggaaaaa gcacggacaa cgtggcaaat 3851761 cgcgtcaact tggcgaatat gagataggaa cttgttgccg agtccttctc ctttagatgc 3851821 gccctttaca atccctgcaa tatcagtgaa ttcaaaagca gtcggcacag tcttcttcgg 3851881 gttgaccagc tcagtcagct tttgcagacg atcatccggc acctctacaa ttcccacgtt 3851941 cggatcaatt gtacagaacg ggtagttggc tgattcggca ccggcctgtg taattgcgtt 3852001 aaatagtgtt gattttccga cgttcggcaa accaacaatt ccagctgtta aagccattct 3852061 ttcatctcct ctatataaaa ccgtcattgt atgaacgtat tttgaaccta gagcaattat 3852121 aaggaggttc actggaaaag acaagctgac aaaaaagcat tttcagcttg ccaatccctt 3852181 tgattatgct tttttcaagc ctactaaaca gtcaaaaagc gtacttccca ttccattatc 3852241 agaatttgta tcatttgtca gtgcattgac tgaccctcca aaagccgccc acatgccttc 3852301 atctatatta atcgtcttcg catgagcctg cttcatcact ttcaccttgc ccttcatgct 3852361 tccgcggtca ttaaagatga caacttcgtc tccatcctga agatcctgcc cagccgctat 3852421 atctggagaa atatcgacct gaacgtgctg aagcttttca ataaacggca catgctgtga 3852481 atgattggaa cgctgcggat gaatggataa gagcgtataa gggtactttc cagctaactc 3852541 ctcattatgg aaaacagatt cttcgggcac atttaattga agcgagccgc taaatccttt 3852601 ttgctcagct agcgacgaag taaattcaaa ttttccactc ggcgtcaaaa actgataatc 3852661 atcccacggc acctgtttta ctggaagagg gaggtggcct ttttctttta aacgctcaag 3852721 tgtcacatcc tctgcttcca atgaagaaag ccccatctct aaaaattctt gagtgctgta 3852781 ttcaaacagc tcgccaaacc caagacgttt tgcaagctct gaccagatcc agctgtccga 3852841 tttcgcttca ccctgcggct ccacaagctt cttcccgtac tgaacataat gatgatacat 3852901 actggaatag tagatatctt cttcttcaaa aacagtggca gtcggcaaaa cataatcaca 3852961 cagctctgcg gtatccgtca taatggaatc aatcgcgacc gtcattggaa ccttttcaaa 3853021 tgcttgtctc accttatttg tattcggcac ctgagtcagc ggatttccgc acgtcacaat 3853081 aatcatctca atcgcaggat cagcagcggt caacacttct tcagcctgtg tcatcattga 3853141 aaaagaacgg gatgttgttt ttaattccgg cagcgtcagc tttgtttttg caaagctctc 3853201 accaatctgg acatttccga aattcgcgcc gccgccctta attccgacat ttccgcttgc 3853261 cgccacaagt gcatcaatcc aacgaatcgt tcccccgccg tttttatatc gctgcatgcc 3853321 aagccccata aaagtagaca ccggaccatc agcatacaaa cctgccaaat actccagctc 3853381 ctccatagaa gtttctgttt tcacaataaa ctcttccaga gaaacggtct tcaaaagctc 3853441 tttcacatca tcaaaaccga cagaatgctc agaaataaac gtttcatccg ttcttcccat 3853501 ctcaatcaga accttcaaaa cggctgccgc aagccagccg tccattccag gctttacaga 3853561 gatatagcgg tcggcaagct tagcagtcgg gttgaagatc ggatcaatca ccgtaatcgt 3853621 ggcgcccttc tttttcacct gctgcaagtg atggtataag tgcatatttg ttcttgatac 3853681 atttcttccc cacacaacaa catgcttgct gttgtaaata tcaagcggtc cgtgaccgta 3853741 cgaacggcca aaatcccagc tttgcgcctc gataccggag ccccagcata tgcttccgac 3853801 gatttcggtc acgccgccat atccattaaa aaaacgctga tcaagcgctt ttaacagacc 3853861 gttattcgca taatcatggc tgtgcaaaac agcagtcgtc tccgacgttt ccttgatttc 3853921 ccgaagttta tcggcaattt catcaagtgc ctgctcccaa gaaatccgca caaactcgcc 3853981 attttgtttt ttcattggat agcgaagccg atcaggcgaa tttgtttttg tctcaagcat 3854041 tctgccgcgg ccgcagattt taccttccgt aatcggatgg tttggatctc cgtccacttt 3854101 tgttaccttt ccatcatcaa cagtcaccaa aaagccgcag ctgtcccaac aattcagcgg 3854161 acatgccgac tgatgcactt tgctcatcgc cgtcttctcc ttaccttcta tatgaaaaag 3854221 catgagtgtc ggcctattta tgaagtaggc tcctcatgct tgactagtac tttttttagt 3854281 tttctttcaa attctcttct cggaatcata acactgtgag agcatccctc acacttaatt 3854341 cgaatatcca ttcccatgcg tataattttc cagctgttcg ctccgcatgg atgcggtttt 3854401 ttcatttcta cgatatcatt caggccaaag tctttatccg ccaagaccct tcacctcttt 3854461 tcctaaactg ctgtatctat tgtacaaaaa aactgatcat aagagcaatc aagatacccg 3854521 aaaagaaata catcctctta tttccattta ctcaaaatag gatataagag cagacaaact 3854581 aacaaataca aattgagcat cccatatatc ggatacaaga acgcgatcaa atcagaaaat 3854641 ccgaaagaag taaaaggtac cattaacact aacaaaatca acacaatcat ccatctcggc 3854701 atatgaataa acgccatcag ccggctggac aaacccagca aaccagctac cgtcgtcgtg 3854761 taaatcgcca ggcacagcac cgccgtcata cataaaaaaa ggaaataagg cgcaccctcc 3854821 agaacggcaa acagcggtat ttcaaactga gaaagggagc ccgccagctc caccaacgtt 3854881 tcattataaa caaatgagat cacgccaaaa ataagaccgc ttgccacact tgcgattttt 3854941 gcttctccga gccctttcat ctctttccca acagaggata aaatcgcaac aactgaaagg 3855001 atgtttaaag aggtaaacgt aatgctcgca ggccagttat actgctggga caaatcaatc 3855061 gtccacgtat ggtgatgtgt gctctgaaag gagatcagcg catataaaag ccccgctact 3855121 aacacaggaa tcaaaatact atttatagat aatattcctt tcacatccca caaaaacaag 3855181 cacactgtca cgatgcaaat cagcgtgatt ccccaccaga aaggaagctt gtacatttgc 3855241 agggtcacac cgcctccggc aatcatcacc atagtcgtcg aaaacaaata aaaaatgatg 3855301 aggacatcat aaattttcgc cagccatggc cccattaaat gctccagaac cggcagaaaa 3855361 tgagtggatt gaaccttaaa actgattttc atcacaatat aagacgagaa aatgaacata 3855421 attgtaaaca gcacaatagc aagtccgctt tccgccccaa aaaactgcca tatctcctga 3855481 ccgctcgcat atccggcccc gatcaggctc cctaatatga gcagcatcca cttcattccg 3855541 gctctccaca acactatcac ctcatagaca aagttcagct tgttcccgtt attgttacta 3855601 tataaataaa ggaaagcaaa catgccatat tttcatagac atttgaacac aagctgaaat 3855661 tatcatacga aatacacata aaaaagactg ctaatacggc agtctaaaaa gagatattta 3855721 tttgtttgtc cgcggaatga agaagtgaac ttcactcttc acttttttct aaccattcct 3855781 acctattcaa gtgtttcata agcagaccat tgcttgatca tgatcgaggc aatgggggac 3855841 aatacttgta atcgcccact aaccattcat atcatgccct ctactttttt aaaatctctg 3855901 gtgccataca caaagcataa aaaatcatac tgctggatat actgtaaaca accttacata 3855961 actacacaca ccatagcaat tctgttacct actataacaa ggaagtgaaa cccatgaatc 3856021 gaaaaggcgg gcttttttct tctcaggaac gagtaaagca atatgtttca catacagatg 3856081 ctgcagcggc aaaacaaatc caaaccatcc tttcttcatc cttacgtaaa gctgctggca 3856141 aaccaattgt cgtggtttgt atcggaacag accgttcaac cggtgactca ttaggcccgc 3856201 tcgtaggaat gaaactcaaa cagatgcagc tcaccagatt ccatgtctac ggaaccttat 3856261 ctgaccccgt ccatgctgtg aacatgaagg ataaaatcaa tgacattcat aaattacata 3856321 aaaacccatt tgttatagca gtcgatgcat gcttaggccg cgttaagagt gtgggttcat 3856381 ttcaaatcgg ggacgggcca ttaaagcccg gagccggtgt acaaaaagac cttcctgaag 3856441 tgggagatct tcatattaac ggaatcgtga atgtgagcgg ttttatggaa tattttgtat 3856501 tgcaaaatac tagactcaac ttggtcatga atatggcaaa tgttctagcg gaaggtttga 3856561 gtttaacaga tcggacagag tggaggcaag aacgccttaa cccgttgcaa aggctcactg 3856621 ggcgcatata aaataaaaac catcttcgtt tgaaagatgg ttttttcatt tatgattctc 3856681 gttcagacaa aagctctaaa atccggtcaa ggtcttcatt agagaaaaat tcaatttcga 3856741 ttttgccttt tttcttctgt cttttaatat taactgttgt tccaaaataa ttttggagat 3856801 aggattcccg ttcttttaga accgcatctt tcacaggttc ttttttcttt gtttcacgtg 3856861 gaacattctg attcaactgc tgaatcagct gctcaagttg gcgaacattg agctgctccg 3856921 caatcacttt ttgtaccagc ggttcaagct tatttttgtt ttttaagcca agaagcgtgc 3856981 gtccatgtcc catagaaagc gtgccttcgg caataagctg ttgaatattt tctggcagtg 3857041 tcagcagtct taaatgattc gcaatatgcg gtctgctttt cccaagacgt ttggcaagct 3857101 gctcttgtgt gagatctaag tgtttcaaaa gggagtcata tgcctgagcc tcttcaagcg 3857161 gagataaatc ttcacgctga aggttttcta ataaagcaat ttccctcatt aacgcctctg 3857221 ataattcacg gacaatggcc ggaactgtat ctaaacctgc cagctttgcc gctcgaaaac 3857281 gccgttcacc cgcaacaata tcatagcctt ttaaagattt tctgacgata agcggctgaa 3857341 gaatgccatg ctgcagcaca gattctttta gttcagctaa tgcctcgtca tcaaagtgtt 3857401 ttcttggctg ataaggatta gggcgtaaat cggcaatttt aatttcttca actgtctctt 3857461 cagacaaatc tacctgatta aataacgcat taatcccttt tccaaggcct ttagccattc 3857521 gcagccactt cctttgctaa atctaaatat acttccgcac ctcttgaccg cggatcgtat 3857581 aaaatgatgg gttttccgtg actcggtgcc tcactcagac ggacattacg cggaataact 3857641 gtcttatata ctttatccct aaaatacttt ttaacctctt caatcacttg aatgccaagg 3857701 tttgtccggg catcaagcat tgtcagcaat acaccttcaa tcattaaatc agtattcaaa 3857761 tgcttttgca caagacgtac tgtatttaat aactggctga gaccctccaa ggcataatat 3857821 tcgcactgta caggaatcac aacggaatcc gaggcagtaa gggcattaat cgtcagcaag 3857881 cccaatgacg gcggacaatc aatgataata taatcataat tttgctttac tgcttcaagc 3857941 gctctcttca atctcacttc tcttgatatt gtaggaacca gctcgatctc agcccctgca 3858001 agctgaatcg tcgcaggaat cacatccaag ttctctactg tcgttgcttt aataatatct 3858061 attacatctg catcatctac taaaatatcg tacacacact gctctacatc ggctttttca 3858121 atccctaatc cgcttgtcgc atttccctgc ggatcaatat ctaccagcag aacccttttc 3858181 cctatgtaag ccaaacatgc cccaaggttg acagacgtcg ttgttttgcc gaccccgcct 3858241 ttttggttcg taattgctat gatttttccc acgatgtcac ctactttcac atgaacatgt 3858301 actatcttgc ttctattcta tcaaaaaaag attaaagcgt ttcatttttt tcatcatttt 3858361 gttccgaatc agaagggaaa taattgaaaa ttcaagcacg ctttatgctt tctcttataa 3858421 attctgcaat ttctatgttt ttttgactta aaaaaggaat ttcttaaaga aaaaaagaag 3858481 aagtcacagt acagaacgtg gaaacaggat ggtgagaaaa tggtttatca aacgaagaga 3858541 gatgtacccg ttacgctgat gattgtgttt ctcatattac tgatacaagc agatgccatt 3858601 gttccttttg tgctgggaaa tatgagagtt tccggctgga tcatttttat tctgctgact 3858661 cttttaaatg gactcatcat ttggagcttt attgacctaa aatatgtatt gaaggaacac 3858721 catctgatca ttaaagccgg attgatcaaa catcaaattc cttatgaaaa catcgataaa 3858781 gtcgttcaaa aaaagaaact atggtccggt tttcgtctga tcggctctcg ccatgccatc 3858841 acaatatatt atcagggggg atggggacat gcagtaattt caccgcaaaa atctgaagaa 3858901 tttatccaca agctcaaaga aaagaattct aatataataa tattcactaa aagtaagtga 3858961 ttaccttttg ttaaaaatat aaaaagctct cctgcttttc aggagagctt ctattttggt 3859021 atgcgaatcg ttaattgaat atattcttca aattcttctt cttccgtatt caattttaca 3859081 ccgctgtctt ccaccattga tagtgactgg cgaatcgtgt tcatcgcaat tcttgtatct 3859141 ctgctgaatg ctttgcgtct cggctttggc tttctctggc cttgctccag cattttcacc 3859201 acgcggtctt ctgtctgctt tacatttaaa cttttctcaa taatctctgt gagcagtgtg 3859261 acttggagct caggctgttt cagcggaatc agtgctctgg catggcgctc ggtgattttc 3859321 ttctccataa tcgcctcttg gaccggctga ggcagcttta ataaccgaag cttattcgcg 3859381 attgtagact gcccttttcc taagcgctgt gcgagtgcct cctgtgttaa atcatgcagc 3859441 tcaagcagcc tagcataagc atgcgcttcc tcaatagaag acagttcttc ccgctgcaag 3859501 ttttcgatta acgccacaga agcggtttcc gtgtcggaaa aatccttaat aattgccgga 3859561 atcttttccc actcaagcga ttgcaccgct ctccagcgtc tttcacctgc aatgagttcg 3859621 tattggcctt cttcttctgt atgcctaaca acaatcggct gaataatgcc gtgtgtatga 3859681 atggtcattg ctaactcttt gattttttca tctgagaaaa tggtgcgtgg ctgaaaacgg 3859741 ttgggaacga tagcatttac cggtatttcc agaatctctt ctttgtttgt atcatgttca 3859801 gcaatctccg gctcctgttc cttctcacca agcccgaaga aacgagagaa tgaatgcttc 3859861 atgtacctac accaccttta aaaactgcca tttttataat tctattttct catggttttt 3859921 cctgctgtac atccatcaat tttgatgaaa atatgatggt attgtcatat caggctgtct 3859981 aaattaccct tcaattggcg atttattagg agttcccggt tttcttggat acttcttagg 3860041 tgtatttttt attttgcgta tcaccataat attacgatcg ctttcttcaa taggcagctt 3860101 aaaagaatgg atattctcaa gttctcctcc aagcgtcgtg attgcttttt tgcctgcatt 3860161 cagttcttct tcagctgatg cggcttttaa agcaacaaat aaaccgtttt tcttcaccag 3860221 aggcaagcaa agctcactca aaacagataa tctcgcaact gcgcgcgccg tcacaatatc 3860281 atagctttca cgcacgtctt tccgttgccc gaacgtttca gctctgtcat ggcagaatgt 3860341 tgtattctcc aattgcaaag cttcagacaa cttttctaaa aacgtaatcc gtttgtttag 3860401 tgaatccacg attgtgacat ggaggtgcgg aaagcatatt tttatcggca gacttggaaa 3860461 acccgctccc gctccaacat cacaaatcgt gttcacctga ttgaagtcga cataaaaagc 3860521 agctgtaatg gaatcataaa aatgctttaa atacacttct tttttctctg ttattgaagt 3860581 cagattgatt ttttcgttcc attcaaccag catgtcgtaa tacagctcaa attgctccag 3860641 ctgacgggga gaaagggaga tccctttttc cgccaaacca gaagtgaatt cttcaatatt 3860701 catgccgtca tcctttctac tcggctatct tcgcaatgcg tccctgctct aaatacacca 3860761 atagaattga aatgtccgcc gggtttacac cggaaatgcg ggaagcctgg gcaacagaca 3860821 aaggccgtac atttttcagt ttttgacgcg cctcggtcgc aatcccctta attgcgtcat 3860881 aatcaattcg gtctggaatt tttttatttt ccatcttctt cagtttttcc acttgctgaa 3860941 gagatttttc aatatatcct tcatatttca cttggatttc tacttgttct gccacgtctt 3861001 gaggaaccgg cacttctggc ggcgccagtt ttgtgactgt ttcatagttc atttcaggac 3861061 gtttcatcaa gtctgtgccg cgaactccat ctttcaattc gcttccgcca agagaacgga 3861121 tatattcttg attttccgga gacggcttga taattacaga atgaagacgt tttttctccg 3861181 cctcgatcgc cgcttttttc ttctcaaaag ccgcatagcg ctcatcagaa atcaatccaa 3861241 tgcgatgtcc gatttctgtc agacgcaaat cagcattgtc atggcgaagc agcaatctgt 3861301 attccgcacg tgatgtcaaa agacgatatg gctcattggt accttttgtc acaaggtcat 3861361 caatcagaac accaatatag gcgtcagaac ggcttagaat tacttcttct tttccaagcg 3861421 cttttcgtcc tgcattgatt cccgccataa tcccttgtcc cgcagcttct tcataaccgg 3861481 atgttccgtt aatttggcct gcagtataaa ggtttgtgat ttttttggtt tcaagtgtcg 3861541 gccatagctg tgtcggtacg attgcatcat actcgatcgc atagccggct ctcatcattt 3861601 gcacgttttc aagtccagga atcgttgcaa gcattctttg ctgtacgtct tctggaagac 3861661 ttgtagataa accttggaca tagacttcct gtgtatttct gccttccggc tcaaggaaga 3861721 tttggtgacg cggtttatca ttaaaacgga caactttgtc ttcaatggat gggcagtatc 3861781 ttgggcccgt acctttgatc ataccggaat acatcggtga acggtgcagg ttgctgtcaa 3861841 taatctcatg tgtctcaggg cttgtatatg tcagccagca agggagctga tctgtgatat 3861901 attccactgt ttcatatgag aaagcgcgag gcacatcgtc accaggctga atttccgttt 3861961 tgctgtaatc aatcgtgtcg cttttaacgc gaggcggcgt acctgtttta aaacgaacaa 3862021 ggtcaaaacc gagttcctcc aaatgctcag aaagcttaat agaaggctgc tggttattcg 3862081 ggccgcttga gtaagacaga tcgccaagaa tgatacgtcc tcttaaatat gtccctgtcg 3862141 tcatgacaac tgctttcgca cgataatgtg cgcctgtttg tgtaataacg cctcggcatt 3862201 cgccgtcttc aacgatcagc cgctccacaa ttccttgcag caatgttaag tttggttctt 3862261 tttcaagcgt atttttcatt tcgtgctgat attggaattt gtctgcttgc gcacgcaatg 3862321 cacgaaccgc aggacctttt cctgtattca gcattctcat ttgaatatgt gttttatcga 3862381 tgtttcttcc catttctccg ccgagcgcgt caatttcgcg gacgacaatc ccttttgcgg 3862441 ggccgccgac agacggatta catggcataa atgcaaccat atctaggttg atggtcaaga 3862501 caagcgtttt ggcgccttgg cgtgcagatg cgagggcagc ctcaacaccg gcatgcccgg 3862561 cgccaatcac aatcacatcg tattggcctg cttcataccc catgattcta gttcctcctt 3862621 taattatttt cctaaacaga attgagaaaa gagctgatca attaagcttt cgtggacaga 3862681 atctccaatg atttccccta aaagctccca gcatcttgta aggtcaattt gcaccatgtc 3862741 gatcgggaca tcctgttcga tgccgctaag cgcatcttca atggcgcgtt ttgcttgctg 3862801 taaaatagtg atgtgacgtg tgttgctgac ataagtcaga tcaccgcttt caatggcacc 3862861 cgtgtagaac agtgattgaa tcgcttcttc cagatcattg atgccttcct cttttaaaag 3862921 agatgtcgta acaactggac gtccattggc aagctcacgg acacgttcag tgtcaatctt 3862981 cggctcaagg tcagtcttat tcaaaatcac gataacatcc atgccctcaa cggcttcaaa 3863041 aagcttcacg tcttcttcag aaagctcttc actataatta agcacaagta aaatcaggtc 3863101 cgcttccttt aggacctggc gagaacgttc aacaccgatt cgctcaacaa tatcctctgt 3863161 ttcacgaata cctgctgtat caaccagacg aagcggaacg ccccttacat tcacgtattc 3863221 ctcaatcaca tcccgtgtcg ttccgggaat atcggttaca atggcttttg cctcatgaac 3863281 gaggctgttc agaagagatg attttcctac gtttggccgg ccgataatga cggtagaaag 3863341 accttcacgc aagatttttc cttgctcaga agtcctcagc agcgtctcaa tttccttttt 3863401 cacggcggtt gccttttcga ctaaaatctg atgcgtcatt tcctctacat catcatactc 3863461 cggataatca atattcacct caacatgggc cagtgtttct aaaatctcac tgcgcaaacg 3863521 gcgcaccaaa gcagaaagac gcccttccat ttgattcata gcaacgttca ttgcccggtc 3863581 cgttttcgct ctgattaagt ccataaccgc ttccgcctgt gaaagatcga ttcggccgtt 3863641 taaaaacgca cgtttcgtaa attcaccagg ctctgccagt ctcgctccct ctctcaatgc 3863701 aagctgaagc acttggttca cagtcacaat tcccccgtga cagttaatct cgatgacatc 3863761 ttctcgtgta aaagttctcg gcgcttttaa cactgatacc attacttcct caacgacacg 3863821 atccgaaggt ctgtctacga tatgaccata atgaatcgta tgtgattcga ccgagctgag 3863881 tgttttcccc ttcggtccct tataaatttt atctgcgatt tgaatggctt ctggtccgct 3863941 caaccgtaca atcgcaatcg cgccttctcc catcggtgtg gaaattgccg caattgtatc 3864001 catgttgttc acctctcttt acttatactt catctatata aaaaaatttt tattatgcca 3864061 aaactaaaag ataacatagt ttggttcgaa gtggaagatt tgttatccac agaaatagaa 3864121 attcgtccct tattacttta acttatccac atgtgaataa caattaattt tatttcctga 3864181 acttcctttt tatcaacagg atacacctaa aaagaaaaaa cttaaacggc aaaaccttga 3864241 tattactagg aaaagtagat ttttcggata caaaaaaacc gaaatccaat ttttatcgga 3864301 cttcggtttt atgctatctt ttatgggaaa taacgagatg acgattttcg ccttcaccca 3864361 ttgaatatgt tttgatctgg tggtttgcat atccagaaag agtatcgtga ataatttttc 3864421 tttcgctgga cggcatgggc tcaagctgga tggatttttt cgttttcaaa acctggtcag 3864481 caagcttgat ggccagctgg ctcagtgttt cttttctttt caaacgatag ttttctgcat 3864541 ccaccgtcac atttttatat tggcctggat aacggttaag ggcaagctgt gtcaaagttt 3864601 caagggcgtt taaagtttgt cctcttttcc caatcaacaa tgctgccttt tcacctgtta 3864661 tatgatatct cactgtcttt ttgctttctt gaacagtcac atcagacttc ccggcaatgg 3864721 cttcggcaat cgtttgaaga tataacttcg cttgctgaat cggatcaatc ttttcaacca 3864781 gctttacgat cgcaggcttt ttaccgaaaa taccgagaaa ccctttgttt ccctcttcaa 3864841 taacagtaat ttctacctta tccttcgtta atcccaactc ttgcaatccg gactgtactg 3864901 cttcatcgac atttcgccct gcagcagtca cattcctcac tttttctttc ctccggcttt 3864961 ttgcggctca ggattttttt taatatcagg tcctttaatg aggaaagttt gcgcaatcat 3865021 aaacaagtta ccaactaccc aataaagaga aagagccgcc gggaagttga tcgcaaatac 3865081 gataatcata attggcataa tccaaagcat catcgccatt tgcggatttt gctgcgcatt 3865141 gccagccatc atcagttttt gctgaacaaa tgtagcgaca ccggcaacga taggaagaat 3865201 atagtaagga tctttttctc ctaagtcaaa ccataagaag ctatgctctg aaatcgcctg 3865261 ggttctcatg atcgcatgat agaatccaat taaaatcggc atctggatca aaatcgggaa 3865321 acatcccgcc aatggattga caccatgctt ttggaataaa gccattgttt cctgttgaag 3865381 cttttgctgc gttttttgat cctttgagct gtatttttct ttaagctttt gcatttccgg 3865441 ctgtaaagcc tgcatcgctt tcgaacttct cagctgctta atcatcagcg gtaaaattaa 3865501 taaacgaatt aaaatggtaa ctagaataat tgaaagcccg tagttatctc ccgtcaattt 3865561 cgctacatac gtaatgagct cagacaatgg atatactacg tacttgtccc agaaatgcgg 3865621 actatctgca gtgatcggct ctttcacact cgagcatcca gccaaaagca tgaatacgcc 3865681 aaccatactt aatagcaacc ctattctcct tttcaacaac atttcctcct ataattaatc 3865741 tttacactct tttattgcaa agcatacttg tatgtatttt agcatctttc agttttaaat 3865801 ggtgtctttt tctgatcaac cagaaaggaa gcgcttttaa aagttgtaag aaagcagtgg 3865861 tgatgcctac tttgacgaag atttcttata taatgaagac tttctgaata gatgctgcag 3865921 actttttttc gtttcctcat atgtcagctg gctcgccggt tttctggcaa taatgatgta 3865981 atccttttcc ttcagtctct ctttctcttc aagaaaggcc tgccgaatca aacgtttgat 3866041 ccgatttcgc atcacagcat tgccaatttt tttgctgacg gaaagcccga cacgcagttc 3866101 atcattttca ggctgatcaa gcgtatataa gacaaactgg cggtttgcaa ctgatgtccc 3866161 atgtttaaac actttttgaa aatcttcatt tttctttaaa cgatttcgct tcttcaaatg 3866221 actcactccg atactggctg gcagaaactt ttaaaattta ttatgaacat gagatgcatc 3866281 tgaaccagga agcatgcccc ggttcattac gcatcacatc tatcttttcc cataacgtga 3866341 aaaaagacca ctgacattat tcagtggcct aagctgataa tacttttctg cctttgcggc 3866401 gacggcgtgc taaaactaga cgaccgtttt ttgaactcat acggcttctg aagccatgaa 3866461 ctttgctgcg tttacggtta ttcggttgga atgttctttt catttatgac acctccctcg 3866521 aggaatagct gttaaagaca gtcttactta ttatatttgc gttacctatt cattgtcaac 3866581 ttcactagtg cttttatttc ttgcaaccat aataggatac catacctttt caactttcga 3866641 aaccttattt tttagattcc ttaattttac ggaaaaaaga caaattcaaa caatttgccc 3866701 ctaaaatcac gcatgtggat atctttttcg gcttttttta gtatccacag aggttatcga 3866761 caacattttc acattaccaa cccctgtgga caaggttttt tcaacaggtt gtccgctttg 3866821 tggataagat tgtgacaacc attgcaagct ctcgtttatt ttggtattat atttgtgttt 3866881 taactcttga ttactaatcc tacctttcct ctttatccac aaagtgtgga taagttgtgg 3866941 attgatttca cacagcttgt gtagaaggtt gtccacaagt tgtgaaattt gtcgaaaagc 3867001 tatttatcta ctatattata tgttttcaac atttaatgtg tacgaatggt aagcgccatt 3867061 tgctcttttt ttgtgttcta taacagagaa agacgccatt ttctaagaaa aggagggacg 3867121 tgccggaag //